bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aerobic training with consumption of Nigella sativa extract ameliorate myelin core protein, axonal regeneration, and cognitive function in a mouse model of multiple sclerosis
Authors: lorestani aziz zinvand , Mirnasouri Rahim , rahmati Masoud , darvishi Marzieh 
Published: August 2023

Abstract
Purpose
Multiple sclerosis (MS) is a progressive disease of the central nervous system (CNS) that leads to demyelination of the CNS and memory impairment in animals suffering from this disease. It seems that the release of neurotrophic factors after training is one of the possible mechanisms for increasing axonal protection and brain health of these patients.
methods
In order to induce MS, cuprizone was added to rodent food powder at a weight ratio of 0.2%. The state of balance in the studied groups was checked by repeated measurement statistical test, the level of expression of brain derived neurotrophic factor (BDNF) and myelin basic protein (MBP) markers by immunohistochemistry, the amount of tumor necrosis factor-alpha (TNF-α) by ELISA method and the evaluation of memory and spatial learning by Morris water maze test.
Results
The amount of MBP in the corpus callosum in the cuprizone (CUP) group was significantly decreased compared to the sham group and significantly increased in the groups treated with training and oral Nigella sativa compared to the CUP group. A significant increase in BDNF and a significant decrease in TNF-α were observed in the treated groups compared to the CUP group.
Conclusion
probably due to the reduction of inflammation and the improvement of myelin, the balance and motor activity of the animals have also improved. These structural changes in the brain anatomy of mice, which show histological changes and in line with its behavioral function, can have a new path for faster diagnosis and prevention of debilitating symptoms.
A National Study on the Comparative Burden of Pedestrian Injuries from Falls Relative to Pedestrian Injuries from Motor Vehicle Collisions
Authors: Rundle Andrew G. , Crowe Remle P. , Wang Henry E. , Beard John R. , Lo Alexander X. 
Published: August 2023

Abstract
Pedestrian injuries from falls are an understudied cause of morbidity. Here we compare the burden of pedestrian injuries from falls occurring on streets and sidewalks with that from motor vehicle collisions. Data on injurious falls on streets and sidewalks, and pedestrian-motor vehicle collisions, to which Emergency Medical Services responded, along with pedestrian and incident characteristics, were identified in the 2019 National Emergency Medical Services Information System database. In total, 129,343 injurious falls and 33,910 pedestrians-motor vehicle collisions were identified, with 89% of the incidents occurring in urban areas. Thirty two percent of pedestrians struck by motor vehicles were coded as Emergent or Critical by Emergency Medical Services, while 20% of pedestrians injured by falls were similarly coded. However, the number of pedestrians whose acuity was coded as Emergent or Critical was 2.33 times as high for injurious falls as compared with pedestrians-motor vehicle collisions. This ratio was nearly double at 4.3 for individuals 50 years and older, and almost triple at 6.5 for those 65 years and older. In conclusion, there has been substantial and appropriate policy attention given to preventing pedestrian injuries from motor vehicles, but disproportionately little to pedestrian falls. However, the population burden of injurious pedestrian falls is significantly greater and justifies an increased focus on outdoor falls prevention, in addition to urban design, policy and built environment interventions to reduce injurious falls on streets and sidewalks, than currently exists across the U.S.
Characterization of root hair curling and nodule development in soybean-rhizobia symbioses
Authors: Lu Wei , Wang Xiaochan , Jia Weidong , Ou Mingxiong 
Published: August 2023

Abstract
Aims
Root hair is the initial infection site for symbiotic (rhizobia) process including rhizobia attaching, root hair deforming, and nodule organ forming. Since roots and nodules are blocked by soil and are hard to be perceived, little knowledge is available on the process of soybean root hair deformation and nodule development over time.
Methods
In this study, adaptive microrhizotrons and root hair processing method were used to observe root hairs and to investigate detailed root hair deformation and nodule formation.
Results
It was found that root hairs were not always straight even in uninfected group with relatively small angle (<30°), but root hair curling angle in infected group were large ranging from 32° to 80° since S2 to S6. Nodule was an organ developed late than root hair curling. It initiated from root axis and began to swell in S3, with color changing from light to dark brown in S5. In order to eliminate the observing error, diameter over 1 mm was converted to real diameter with relative formulation. And after conversion, diameter of nodule reached 5 mm in S6. Relationship between root hair curling number/angle and nodule number/diameter indicated that curling angle was strongly related to log nodule diameter (R2 0.84), and curling number was strongly linear to nodule number (R2 0.91).
Conclusions
Thus, nodule number could be calculated through the derived formulation and nodule diameter could be observed and converted to real diameter nondestructively.
Streamlining Email Automation: Seamless Integration of Automation 360 with Outlook and Power Automate Cloud Flows for Continuous Email Monitoring and Unattended Bot Deployment
Authors: Potturu Sai Madhur 
Published: August 2023

Abstract
This research paper explores the integration of Automation 360 platform with Outlook and Power Automate cloud flows to enable continuous monitoring of shared mailbox folders and deploy unattended bots in response to incoming emails. This integration is achieved by leveraging the A360 bot deploy API, allowing different systems to trigger bots. The paper outlines two monitoring and integration methods. The first approach involves setting up VBA code in Outlook to monitor shared mailbox folders and trigger the A360 bot deploy API. This ensures the deployment of unattended bots when emails arrive in designated folders. The second approach utilizes Power Automate cloud flows to monitor shared mailbox folders and deploy unattended bots using the A360 Bot deploy API. The integration of Outlook, Power Automate, and A360 provides several advantages, including timely responses to customer inquiries, improved automation communication, and increased efficiency in email-based processes. Moreover, it optimizes the usage of unattended bot runners, enabling the deployment of scalable and high ROI automation solutions on these runners. By following the outlined steps and leveraging the capabilities of these tools, organizations can streamline their email-based processes, enhance productivity, and achieve greater automation efficiency. The integration of A360 with Outlook and Power Automate provides a comprehensive solution for continuous email monitoring and efficient utilization of automation resources.
Kimura Disease: A Rare Case in Vietnamese Woman
Authors: Le Linh Nguyet , Tran Linh Ngoc Tuong , Pham Duy Le 
Published: August 2023

Abstract
Background: Kimura disease (KD) is a rare benign chronic inflammatory condition that predominantly affects Asian males. It is characterized by subcutaneous tissue masses in the head and neck region, enlarged lymph nodes, increased blood eosinophilia, and elevated serum total IgE levels. In this report, we describe a rare case of KD in a young Vietnamese female.
Case summary: A 31-year-old Vietnamese woman presented to the hospital with 2 masses in the bilateral cheeks and 1 mass behind the left ear that persisted for 15 years, recurrent skin itching, elevated serum total IgE levels and increased blood eosinophilia. No medical history of the individual or family was recorded. We performed an excision biopsy of the postauricular mass which revealed follicular hyperplasia with small vessel hyperplasia, diffuse infiltration of eosinophils in lymphoid follicles, and several eosinophilic microabscesses. After a comprehensive review, the final diagnosis for this patient was KD and atopic dermatitis comorbidity.
Conclusion: KD is not limited to males, as this report demonstrated. The histopathological examination plays an important role in the diagnosis of KD. This case illustrated the characteristic description of KD and highlights the need for awareness of this rare disease in Asian women.
Ultra-broadband and wide-angle thin metamaterial solar absorber based on the square-disk array
Authors: Luo Fuyin , Liu Mingjie , Zhao Yujie , Shi Wenhui , Li Chuanliang , He Xiaohu 
Published: August 2023

Abstract
In this paper, an ultra-wideband solar absorber consisting of a four-layer structure of Al2O3-TiN-Al2O3-Ti is proposed. The proposed absorber achieves an average absorption of 97.85% in the wavelength range of 250–2000 nm (49.96% improvement over the reference planar structure), and its bandwidth of absorption over 90% is even as high as 1742 nm. As a result of the symmetrical design of the structure, the absorber has a polarization insensitivity as well as a wide-angle absorption characteristic. In particular, the absorber has a large process tolerance in the structural parameters and a high degree of universality for other metals and dielectric materials, which is highly advantageous in manufacturing. In addition, we explored the reasons for the high absorption of the structure in detail, discussed the influence of different structures on the absorption, and analyzed the absorption characteristics of the structure under the solar spectrum. The proposed structure provides a broader bandwidth and higher light absorption than the recently reported work and further reduces the structure's thickness. Therefore, the absorber will have broad application prospects in photothermal conversion, solar cells, imaging, and stealth.
MiR-21-5p delivered by exosomes of placental mesenchymal stem cells targets the PTEN/AKT/mTOR axis to inhibit ovarian granulosa cell apoptosis
Authors: Liu huidong , Zhang Xiao , Wang Shao-wei 
Published: August 2023

Abstract
Background: This study aims to determine the therapeutic effect of placental mesenchymal stem cell exosomes ((PMSC-Exos) on premature ovarian insufficiency (POI) and explore the mechanism of inhibiting ovarian granulosa cells (OGCs) apoptosis.
Methods: Exos were extracted from PMSCs and identified by transmission electron microscopy(TEM), nanoparticle tracking analysis(NTA), and Western blot (WB). OGC induced by cisplatin was used to establish POI models in vitro, and the therapeutic effect of PMSC-Exos on POI was evaluated by flow cytometry, WB, cell counting kit-8 (CCK-8), and wound-healing assay. The results of miRNA microarray assay of PMSC-Exos showed that miR-21-5p was the most enriched miRNA. The target gene of miR-21-5p identified by the database and references was PTEN. The regulatory effect of miR-21-5p on PTEN was verified by dual luciferase reporter assay, WB, and qRT-PCR. Then, rescue experiments were designed to fully confirm the regulatory mechanism of miR-21-5p on the PTEN/AKT/mTOR axis. Finally, WB, flow cytometry, CCK-8, and wound-healing assay were used to verify that miR-21-5p carried by PMSC-Exos protected OGCs by targeting the PTEN/AKT/mTOR axis.
Results: The co-culture of PMSC-Exos with OGCs inhibited cisplatin-induced apoptosis and promoted cell proliferation and migration. These therapeutic effects significantly decreased after miR-21-5p knockdown. Dual luciferase reporter assay, WB, and qRT-PCR verified that miR-21-5p could target PTEN to inhibit its expression. Finally, multiple experimental groups were designed to verify that miR-21-5p delivered by PMSC-Exos to granulosa cells could bind to the 3ʹ untranslated region (UTR) of PTEN, thus regulating the AKT/mTOR pathway and playing a positive role in inhibiting apoptosis of OGCs and promoting cell proliferation and migration.
Conclusion: MiR-21-5p carried by PMSC-Exos inhibits OGCs apoptosis by targeting the PTEN/AKT/mTOR axis. This finding provides a new idea for the precision treatment of POI and the cell-free treatment of Exos.
A Novel Approach of Stock Price Direction and Price Prediction Based on News Sentiments
Authors: Singh Harmanjeet , Malhotra Manisha 
Published: August 2023

Abstract
Forecasting stock trends guide investment management, financial policy, and the country’s economic growth. Investor-generated textual information has impacted stock movements across media channels in recent years. Most sentiment index studies weigh linguistic content equally. Such studies ignore that the sentiment index’s impact on the stock market decreases over time. This study analyses stock indices using dual classifier coupling and sentiment analysis. A dual classifier is created by combining two popular classifiers, Decision Tree (DT) with Convolution Bi-Directional Gated Recurrent Unit (GRU). The proposed model is tested using Reliance Industries shares. The adjusted sentiment index improved overall accuracy in the Reliance Industries stock news sentiment analysis case study by 84.12 percent. The investor sentiment indicator improves stock index trend prediction, as shown by a 3.16 RMSE (Root Mean Squared Error) and 0.97 R2(Coefficient of determination) reduction. The adjusted sentiment index improves predicted accuracy considerably. The investors’ sentiments improve the overall results in Reliance Industries’ stock price prediction with our fusion of pro- posed VADER (Valence Aware Dictionary and sEntiment Reasoner) and CNN + BDGRU models compared to benchmark models.
Gene expression-phenotype association study reveals the dual role of TNF- α/TNFR1 signaling axis in confined breast cancer cell migration
Authors: Cruceriu Daniel , Balacescu Loredana , Baldasici Oana , Gaal Orsolya I. , Balacescu Ovidiu , Russom Aman , Irimia Daniel , Tudoran Oana 
Published: August 2023

Abstract
While enhanced tumor cell migration is a key process in the tumor disemination, mechanistic insights into causal relationships between tumor cells and mechanical confinement are still limited. Here we combine the use of microfluidic platforms to characterize cell migration with genetic tools to systematically unravel the global signaling landscape associated with the migratory phenotype of breast cancer (BC) cells. The migration capacity of seven BC cell lines was evaluated in 3D microfluidic devices and their migration capacity was associated with their molecular signature. The gene expression of 715 genes was correlated with the migratory phenotype. TNF-α was found to be one of the most important upstream regulators of the signaling networks in which these 715 genes participate. Furthermore, the expression of the main TNF-α receptor, TNFR1, was strongly associated with the migration capacity, but also with a triple-negative, mesenchymal phenotype. In order to assess the impact of TNF-α/TNFR1 signaling axis on the BC migration capacity, either rhTNF-α was administrated or TNFR1,was silenced by siRNA, in four phenotypically diverse BC cell lines. In each experimental setting, the cell migration capacity was evaluated in microfluidic devices, while the molecular effects triggered by the treatment were monitored by RT-qPCR. According to our results, TNF-α stimulates the confined migration of triple negative, mesenchymal-like BC cells that are also characterized by high TNFR1 expression, but inhibits the migration of epithelial-like cells with low TNFR1 expression. Downstream of TNF/TNFR1 signaling, transcriptional regulation of NFKB seems to be dominant in driving cell migration in confined spaces.
The Interplay between Chinese EFL Teachers’ Resilience and Agency
Authors: Qin Lili , Derakhshan Ali , Wang Yunsong , He Yanhua 
Published: August 2023

Abstract
Background
While teacher resilience has been shown to be a key factor in teachers’ development, a bulk of research on resilience in the field of foreign language education has largely focused on how teachers exercise resilience during challenges. Moreover, the interrelationship between resilience and agency has received sparse scholarship. It is also unclear how teachers in a foreign language context implement and show their resiliency and agency.
Method
This study intends to fill these gaps by investigating foreign language teachers’ perceived resilience had its association with their agency. For this purpose, a mixed-methods design was utilized based on a questionnaire and an interview.
Results
Teachers’ resilience and agency were found to be at a higher level, and there was a causal relationship between resilience and agency.
Conclusion
The impact of uncertainty in the new working situation seemed to have been buffered by teachers’ social interaction with experts and peers. In addition, the role of teacher identity was flagged up in the interplay between teacher resilience and agency. This study advances research on teachers’ resilience with the consideration of agency and suggests implications for teachers and teacher educators to activate teachers’ resilience and agency.
Longitudinal course and predictors of health-related quality of life, mental health, and fatigue, in non-hospitalized individuals with or without post COVID-19 syndrome
Authors: Kirchberger Inge , Meisinger Christine , Warm Tobias D. , Hyhlik-Dürr Alexander , Linseisen Jakob , Goßlau Yvonne 
Published: August 2023

Abstract
Background
Long-term information on health-related quality of life (HRQOL) and mental health of non-hospitalized individuals with „post COVID-19 syndrome“ (PCS) is scarce. Thus, the objectives of the present study were to compare HRQOL and mental health of individuals with and without PCS in a German sample of non-hospitalized persons after SARS-CoV-2 infection, to characterize the long-term course up to 2 years and to identify predictors for post COVID-19 impairments.
Methods
Individuals with past COVID-19 were examined at the University Hospital of Augsburg from November 2020 to May 2021 and completed a postal questionnaire between June and November 2022. Participants who self-reported the presence of fatigue, dyspnea on exertion, memory problems or concentration problems were classified as having PCS. HRQOL was assessed using the Veterans RAND 12-Item Health Survey, mental health was measured by the Patient Health Questionnaire and the Fatigue Asessment Scale was used to assess fatigue severity. Multivariable linear regression models with inverse probability weighting were used to determine the association between PCS and health outcomes.
Results
From the 304 participants (58.2% women, median age 53 years), 210 (69.1%) were classified as having PCS in median 26 months after COVID-19 onset. Persons with PCS showed significantly more often depressive and anxiety disorders. PCS was independently and significantly associated with higher levels of depression, post-traumatic stress and fatigue, as well as poorer physical and mental HRQOL in median 9 months as well as 26 months after COVID-19 onset. A large number of acute symptoms and a prior diagnosis of depression were independently associated with poor mental health and HRQOL. While post-traumatic stress and mental HRQOL improved from 9 months to 26 months post infection onset, depressiveness, fatigue and physical HRQOL remained stable in both, persons with and without PCS.
Conclusions
PCS in non-hospitalized persons after COVID-19 is often associated with long-term impairments of mental health and HRQOL outomes.
Laser Interstitial Thermal Therapy for Deep-seated Perivascular Brain Tumors is Not Associated with Distal Ischemia
Authors: Reese Jared C. , Fadel Hassan A. , Pawloski Jacob A. , Samir Mariam , Haider Sameah , Komatar Ricardo J. , Luther Evan , Morell Alexis A. , Ivan Mike E. , Robin Adam M. , Kalkanis Steven N. , Lee Ian Y. 
Published: August 2023

Abstract
Purpose
Laser interstitial thermal therapy (LITT) is a minimally invasive cytoreductive treatment option for brain tumors with a risk of vascular injury from catheter placement or thermal energy. This may be of concern with deep-seated tumors that have surrounding end-artery perforators and critical microvasculature. The purpose of this study was to assess the risk of distal ischemia following LITT for deep-seated perivascular brain tumors.
Methods
A retrospective review of a multi-institution database was used to identify patients who underwent LITT between 2013–2022 for tumors located within the insula, thalamus, basal ganglia, and anterior perforated substance. Demographic, clinical and volumetric tumor characteristics were collected. The primary outcome was radiographic evidence of distal ischemia on post-ablation magnetic resonance imaging (MRI).
Results
61 LITT ablations for deep-seated perivascular brain tumors were performed. Of the tumors treated, 24 (39%) were low-grade gliomas, 32 (52%) were high-grade gliomas, and 5 (8%) were metastatic. The principal location included 31 (51%) insular, 14 (23%) thalamic, 13 (21%) basal ganglia, and 3 (5%) anterior perforated substance tumors. The average tumor size was 19.6 cm3 with a mean ablation volume of 11.1 cm3. The median extent of ablation was 92% (IQR 30%, 100%). Two patients developed symptomatic intracerebral hemorrhage after LITT. No patient had radiographic evidence of distal ischemia on post-operative diffusion weighted imaging.
Conclusion
We demonstrate that LITT for deep-seated perivascular brain tumors has minimal ischemic risks and is a safe cytoreductive treatment option for otherwise difficult to access intracranial tumors.
A nomogram model predicting the risk of high-grade cervical squamous intraepithelial lesions: a population-based study
Authors: Zhao Weihong , Wen Songquan , Li Qi , Wang Jingfang , Zhang Lili , Wang Yonghong , Wang Tong , Hao Min 
Published: August 2023

Abstract
Purpose: This study aimed to develop a nomogram for the prediction of high-grade cervical squamous intraepithelial lesions (HSILs).
Methods: This cross-sectional study included the baseline data of the Shanxi Cervical Intraepithelial Neoplasia (CIN) cohort study, in which 1,249 community-dwelling adults (372 patients with pathologically diagnosed CIN and 877 patients with a normal cervix) from a rural area of Shanxi, China, were recruited. Interviewer-administered questionnaires on sociodemographic characteristics, hygiene habits, marriage and childbearing information, and past medical and family histories of cancer were obtained. Human papillomavirus (HPV) infection types were detected by flow-through hybridization. Logistic regression analysis of independent risk factors for HSILs and a nomogram prediction model were established.
Results: Of the 1,249 participants, 460 (36.83%) were infected with high-risk HPV (HR-HPV), and the five most frequent types of HPV were HPV16, HPV52, HPV58, HPV56, and HPV33. After adjusting for demographics and other related variables, HPV16 was associated with an 11.363-fold (95% confidence interval [CI], 6.639–19.449) higher risk of HSILs and HPV58 was associated with a 5.758-fold (95% CI, 2.542–13.045) higher risk of HSILs compared to the uninfected group. HR-HPV infection, younger age at menarche, menopause, and tea drinking were selected as nomogram covariates. The concordance index of the nomogram prediction model was 0.822.
Conclusion: The most common highly pathogenic HR-HPV types in the study area are HPV16 and HPV58. An easy-to-use nomogram, with reliable discrimination ability and accuracy, was established to help predict HSILs using the identified significant risk factors.
Trial registration: This study was registered by the China Clinical Trials Center (registration number: ChiCTR-ROC-15006479).