bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring access to community care and emergency department use among people with dementia: A qualitative interview study with people with dementia, and current and bereaved caregivers
Authors: Williamson Lesley E. , Sleeman Katherine E. , Evans Catherine J. 
Published: July 2023

AbstractObjectivesEmergency department (ED) attendance is common among people with dementia and associated with poor health outcomes. Literature suggests a link between access to community care and the ED, but we know little about the mechanisms behind this link. This study aimed to explore experiences of accessing community and emergency care among people affected by dementia.MethodsInformed by critical realism, semi‐structured online and telephone interviews were conducted with people with dementia and family caregivers, with and without experience of using the ED. Participants were recruited from across the United Kingdom using purposive sampling with maximum variation. A mostly experiential reflexive thematic analysis approach was used, applying the candidacy model of access to deepen interpretation.ResultsTwo dyad and 33 individual interviews were conducted with 10 people with dementia, 11 current caregivers and 16 bereaved caregivers (men = 11, 70–89 years = 18, white ethnicity = 32). Three themes are reported: (1) Navigating a ‘push system’, (2) ED as the ‘last resort’, and (3) Taking dementia ‘seriously’. Themes describe a discrepancy between the configuration of services and the needs of people affected by dementia, who resort to the ED in the absence of accessible alternatives. Underlying this discrepancy is a lack of systemic prioritisation of dementia and wider societal stigma.ConclusionAlthough a last resort, ED attendance is frequently the path of least resistance for people with dementia who encounter multiple barriers for timely, responsive access to community health and social care. Greater systemic prioritisation of dementia as a life‐limiting condition may help to reduce reliance on the ED through essential development of post‐diagnostic care, from diagnosis to the end of life.
Improving the quality of family planning services in the Philippines: Barriers and opportunities
Authors: Trisolini Michael , Javier Ma. Elena , Jabar Melvin , Rodriguez Cristina , Varquez Jessie , Danganan Omega Diadem , Benabaye Rosario Marilyn , Reynaldo Chris‐Angelo , Conti‐Lopez Mary Angeli , Dela Rosa Jose Juan , Mendoza Ophelia , Dasmarinas Easter , Stan Laurentiu , Bisson Cristina , Oliveros Yolanda 
Published: July 2023

AbstractWe conducted qualitative research with family planning clients, potential clients, and service providers on barriers and opportunities for improving the quality of family planning services in the Philippines. The family planning service providers included the primary, secondary, and tertiary levels of the health system. Our goal was to aid in developing more effective family planning quality improvement (QI) programs. Our methods included focus groups, key informant interviews and thematic content analysis of the qualitative data. We found four themes: the components of quality of family planning care; factors influencing quality; challenges for improving quality; and provider bias in the types of family planning services offered to clients. We identified five implications for QI, including: reduce provider bias; level off the understanding of QI concepts and roles among the different family planning service providers; involve men more actively; design new digital communication strategies for reaching clients and potential clients; and explore collaborations with private sector pharmacies. The findings from this study can guide the development of a pilot family planning QI programme in the Philippines. The findings provide themes and practical insights for an intervention‐focused theory of change on how to improve current programs, design new programs, be more responsive to the needs and concerns of clients and potential clients and be well‐accepted and sustained by providers. This can lay the groundwork for improving family planning outcomes and reducing teenage pregnancy rates and the unmet need for family planning throughout the Philippines.
An assessment of token value and effectiveness: A replication
Authors: Hangen Marcella M. , Romero Ashley N. , Norris Halle M. , Gorycki Kathryn A. , Roberts Breanna R. , Neidert Pamela L. 
Published: July 2023

AbstractThe purpose of the current study was to conduct a systematic replication of Fiske et al. (2015) to extend the behavior‐analytic literature on token reinforcement. Specifically, the researchers addressed several of the limitations of Fiske et al. by including specific conditioning procedures, creating a controlled history of reinforcement with the token system, including participants with and without disabilities to extend the generality of the findings, and equating the magnitude of reinforcement across the primary and paired‐token conditions. The current study evaluated the reinforcing value of tokens by using progressive‐ratio schedules to compare the efficacy of primary reinforcement, paired tokens, and unpaired tokens. The results suggest that paired tokens may function as reinforcers, but they were not as consistently effective as primary reinforcers.
Skin‐color‐independent robust assessment of capillary refill time
Authors: Bachour Raquel P. de Souza , Dias Eduardo Lopes , Cardoso George C. 
Published: July 2023

AbstractCapillary Refill Time (CRT) assesses peripheral perfusion in resource‐limited settings. However, the repeatability and reproducibility of CRT measurements are limited for individuals with darker skin. This paper presents quantitative CRT measurements demonstrating good performance and repeatability across all Fitzpatrick skin phototypes. The study involved 22 volunteers and utilized controlled compression at 7 kPa, an RGB video camera, and cocircular polarized white LED light. CRT was determined by calculating the time constant of an exponential regression applied to the mean pixel intensity of the green (G) channel. An adaptive algorithm identifies the optimal regression region for noise reduction, and flags inappropriate readings. The results indicate that 80% of the CRT readings fell within a 20% range of the expected CRT value. The repetition standard deviation was 17%. These findings suggest the potential for developing reliable and reproducible quantitative CRT methods for robust measurements in patient triage, monitoring, and telehealth applications.
Photophysics of tzAdenine and tzGuanine fluorescent nucleobases embedded into DNA and RNA
Authors: Beal Roiney , Valverde Danillo , Gonçalvez Paulo F. B. , Borin Antonio Carlos 
Published: July 2023

AbstractUV–VIS photoinduced events of tzA and tzG embedded into DNA and RNA are described by combining the Extended Multi‐State Second‐Order Perturbation Theory (XMS‐CASPT2) and electrostatic embedding molecular mechanics methods (QM/MM). Our results point out that the S1 1(ππ* La) state is the bright state in both environments. After the photoexcitation to the S1 1(ππ* La) state, the electronic population evolves barrierless towards its minimum, from where the excess of energy can be dissipated by fluorescence. As the minimum energy crossing point structure between the ground and first bright states lies in a high‐energy region, the direct internal conversion to the ground state is an unviable mechanism. Other spectroscopic properties (for instance, absorption and Stokes shifts) and comparisons with photochemical properties of canonical nucleobases are also provided.
Promoting effect ofN2calcination onFeCeOxfor selective catalytic reduction ofNOxwithNH3
Authors: Xie Lijuan , Du Kenan , Ren Sihan , Liu Fudong , Deng Yun , Ruan Wenquan 
Published: July 2023

AbstractBACKGROUNDSelective catalytic reduction of NOxwith NH3(NH3‐SCR) technology is effective for NOxremoval. Acidity and redox ability are two significant characteristics for NH3‐SCR catalysts. This study investigated the effects of N2calcination on the NH3‐SCR performance of FeCeOx, inspired by the promotion of active oxygen species with inert atmosphere calcination. The structure‐activity relationship and reaction mechanism of the two catalysts (Fe9CeOx‐N2and Fe9CeOx‐air) were concluded based on the results of characterization.RESULTSFe9CeOx‐N2showed better NOxconversion and SO2resistance than Fe9CeOx‐air, especially in low and medium temperature range. For fresh catalysts, a higher amount of Oα, Fe3+and Ce3+promoted the redox ability of Fe9CeOx‐N2, and further improved the NOxadsorption and activation. Additionally, the greater number of acid sites of Fe9CeOx‐N2was another reason for its competitive performance. For SO2‐poisoned catalysts, the primary reaction pathway was the reaction between pre‐adsorbed NH3species and NOx. The higher amount of acidity from metal sulfate contributed to its better SO2tolerance of Fe9CeOx‐N2.CONCLUSIONHigher redox ability and acidity led to better NH3‐SCR activity and SO2tolerance of Fe9CeOx‐N2. This study provides a feasible preparation method for enhancing the NOxconversion and SO2tolerance of NH3‐SCR catalysts. © 2023 Society of Chemical Industry.
Synthesis, characterization, anti‐proliferative evaluation, and molecular docking study of some new N‐(1, 3‐dioxoisoindolin‐4‐yl)acetamide derivatives
Authors: Narode Hanuman , Gayke Manoj , Bhosale Rajesh S. , Kharat Kiran R. , Pawar Rajendra , Yadav Jhillu Singh 
Published: July 2023

AbstractA series of new N‐(1,3‐dioxoisoindolin‐4‐yl)acetamide derivatives were designed and synthesized via a condensation reaction between N‐(1,3‐dioxo‐1,3‐dihydro isobenzofuran‐4‐yl)acetamide and various aliphatic and aromatic amines in water as an environmentally friendly solvent. All synthesized compounds (NPD 1–14) molecular structure was confirmed by their FTIR, 1H NMR, 13C NMR, and mass spectroscopy. The final target compounds were screened for their in vitro antiproliferative activity by taking 5‐Fluorouracil (5‐FU) as a reference drug. Among 14 newly synthesized compounds, five compounds were shown to be effectively cytotoxic against the MCF7 cells. In comparison to the standard medication drug 5‐FU (CC50 = 11.219 ± 0.847), the synthesized compounds NPD‐8 (CC50 = 16.14 ± 2.08 μM) and NPD‐12 (CC50 = 11.26 ± 1.158 μM) demonstrated the most active against the MCF7 cells. Furthermore, in silico study was performed to find molecular level interaction of active compounds with anticancer drug target enzyme NUDT5 inhibitors block hormone signaling in breast cancer cells. The compound NPD‐12 showed the highest molecular binding energy −8.3 kcal/mol which interacted more effectively than the reference drug 5‐FU binding energy −4.6 kcal/mol. These synthesized N‐(1,3‐dioxoisoindolin‐4‐yl) acetamide derivatives have been identified as a potential class of chemicals for further research as plausible new anticancer entities.
RNA‐binding motif protein 24 inhibits HBV replication in vivo
Authors: Yao Yong‐Xuan , Chen Yingshan , Huang Dan , Liu Canyu , Sun Hao , Zhou Yuan , Pei Rongjuan , Wang Yun , Wen Zhe , Yang Bo , Chen Xinwen 
Published: July 2023

AbstractDespite the extensive use of effective vaccines and antiviral drugs, chronic hepatitis B virus (HBV) infection continues to pose a serious threat to global public health. Therapies with novel mechanisms of action against HBV are being explored for achieving a functional cure. In this study, five murine models of HBV replication were used to investigate the inhibitory effect of RNA binding motif protein 24 (RBM24) on HBV replication. The findings revealed that RBM24 serves as a host restriction factor and suppresses HBV replication in vivo. The transient overexpression of RBM24 in hydrodynamics‐based mouse models of HBV replication driven by the CMV or HBV promoters suppressed HBV replication. Additionally, the ectopic expression of RBM24 decreased viral accumulation and the levels of HBV covalently closed circular DNA (cccDNA) in an rcccDNA mouse model. The liver‐directed transduction of adeno‐associated viruses (AAV)‐RBM24 mediated the stable hepatic expression of RBM24 in pAAV‐HBV1.2 and HBV/tg mouse models, and markedly reduced the levels of HBV cccDNA and other viral indicators. Altogether, these findings revealed that RBM24 inhibits the replication of HBV in vivo, and RBM24 may be a potential therapeutic target for combating HBV infections.
Interactions of zinc with phytate and phytase in the digestive tract of poultry and pigs: a review
Authors: Philippi Hanna , Sommerfeld Vera , Windisch Wilhelm , Olukosi Oluyinka Abiona , Monteiro Alessandra , Rodehutscord Markus 
Published: July 2023

AbstractPhytase supplementation is gaining importance in animal nutrition because of its effect on phosphorus (P) digestibility and the increasing relevance of P for sustainable production. The potential inhibitors of phytase efficacy and phytate degradation, such as calcium (Ca) and zinc (Zn), have been a subject of intense research. This review focuses on the interactions of Zn with phytate and phytase in the digestive tract of poultry and pigs, with an emphasis on the effects of Zn supplementation on phytase efficacy and P digestibility. In vitro studies have shown the inhibitory effect of Zn on phytase efficacy. However, relevant in vivo studies are scarce and do not show consistent results for poultry and pigs. The results could be influenced by different factors, such as diet composition, amount of Zn supplement, mineral concentrations, and phytase supplementation, which limit the comparability of studies. The chosen response criteria to measure phytase efficacy, which is mainly tibia ash, could also influence the results. Compared to poultry, the literature findings are somewhat more conclusive in pigs, where pharmacological Zn doses (≥ 1000 mg kg−1 Zn) appear to reduce P digestibility. To appropriately evaluate the effects of non‐pharmacological Zn doses, further studies are needed that provide comprehensive information on their experimental setup and include measurements of gastrointestinal phytate degradation to better understand the mechanisms associated with Zn and phytase supplements. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
The Effectiveness of Ultraviolet Smart D60 in Reducing Contamination of Flexible Fiberoptic Laryngoscopes
Authors: Ezeh Uche C. , Achlatis Efstratios , Crosby Tyler , Kwak Paul E. , Phillips Michael S. , Amin Milan R. 
Published: July 2023

ObjectiveTo compare the effectiveness of disinfection protocols utilizing a ultraviolet (UV) Smart D60 light system with Impelux™ technology with a standard Cidex ortho‐phthalaldehyde (OPA) disinfection protocol for cleaning flexible fiberoptic laryngoscopes (FFLs).MethodsTwo hundred FFLs were tested for bacterial contamination after routine use, and another 200 FFLs were tested after disinfection with one of four methods: enzymatic detergent plus Cidex OPA (standard), enzymatic detergent plus UV Smart D60, microfiber cloth plus UV Smart D60, and nonsterile wipe plus UV Smart D60. Pre‐ and post‐disinfection microbial burden levels and positive culture rates were compared using Kruskal‐Wallis ANOVA and Fisher's two‐sided exact, respectively.ResultsAfter routine use, approximately 56% (112/200) of FFLs were contaminated, with an average contamination level of 9,973.7 ± 70,136.3 CFU/mL. The standard reprocessing method showed no positive cultures. The enzymatic plus UV, microfiber plus UV, and nonsterile wipe plus UV methods yielded contamination rates of 4% (2/50), 6% (3/50), and 12% (6/50), respectively, with no significant differences among the treatment groups (p > 0.05). The pre‐disinfection microbial burden levels decreased significantly after each disinfection technique (p < 0.001). The average microbial burden recovered after enzymatic plus UV, microfiber plus UV, and nonsterile wipe plus UV were 0.40 CFU/mL ± 2, 0.60 CFU/mL ± 2.4, and 12.2 CFU/mL ± 69.5, respectively, with no significant difference among the treatment groups (p > 0.05). Micrococcus species (53.8%) were most frequently isolated, and no high‐concern organisms were recovered.ConclusionDisinfection protocols utilizing UV Smart D60 were as effective as the standard chemical disinfection protocol using Cidex OPA.Level of EvidenceNA Laryngoscope, 133:3512–3519, 2023
Coding of real‐valued continuous functions under WKL$\mathsf {WKL}$
Authors: Kawai Tatsuji 
Published: July 2023

AbstractIn the context of constructive reverse mathematics, we show that weak Kőnig's lemma () implies that every pointwise continuous function is induced by a code in the sense of reverse mathematics. This, combined with the fact that implies the Fan theorem, shows that implies the uniform continuity theorem: every pointwise continuous function has a modulus of uniform continuity. Our results are obtained in Heyting arithmetic in all finite types with quantifier‐free axiom of choice.
The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers
Authors: Zhou Wencheng , Cao Xinran , Xu Qiang , Qu Jiao , Sun Yang 
Published: July 2023

AbstractNeutrophils are important immune cells act as the body's first line of defense against infection and respond to diverse inflammatory cues. Many studies have demonstrated that neutrophils display plasticity in inflammatory diseases and cancers. Clarifying the role of neutrophil heterogeneity in inflammatory diseases and cancers will contribute to the development of novel treatment strategies. In this review, we have presented a review on the development of the understanding on neutrophil heterogeneity from the traditional perspective and a high‐resolution viewpoint. A growing body of evidence has confirmed the double‐edged role of neutrophils in inflammatory diseases and tumors. This may be due to a lack of precise understanding of the role of specific neutrophil subsets in the disease. Thus, elucidating specific neutrophil subsets involved in diseases would benefit the development of precision medicine. Thusly, we have summarized the relevance and actions of neutrophil heterogeneity in inflammatory diseases and cancers comprehensively. Meanwhile, we also discussed the potential intervention strategy for neutrophils. This review is intended to deepen our understanding of neutrophil heterogeneity in inflammatory diseases and cancers, while hold promise for precise treatment of neutrophil‐related diseases.
A de novo variant of BICRA results in Coffin–Siris syndrome 12
Authors: Tu Youquan , Fang Chunyan , Xu Jian , Zhou Yun , Liang Mengmeng , Yang Zuozhen 
Published: July 2023

AbstractBackgroundBICRA, a transcript regulator, was identified as the genetic factor of Coffin–Siris syndrome 12 (CSS12) recently, which was characterized by diverse neurodevelopmental delays. Up to now, limited studies of BICRA in neurodevelopmental delay have been reported.MethodsClinical data such as EEGs, MRIs, routine blood, and physical examination were collected. Trio whole exome sequencing (WES) of the family was performed, and all variants with a minor allele frequency (<0.01) in exon and canonical splicing sites were selected for further pathogenic evaluation. Candidate variants were validated by Sanger sequencing. The BICRA‐related literature was reviewed and the clinical characteristics were summarized.ResultsWe reported a CSS12 proband with a narrow and slightly clinical phenotype who only exhibited language developmental delay, hypotonia, and slight gastrointestinal features. WES revealed a de novo variant in exon 6 of BICRA [NM_015711.3: c.1666C>T, p.Gln556*]. This variant resulted in an early translation termination at 556th of BICRA, not collected in the public population database (gnomAD), and classified as pathogenic according to the ACMG guideline.ConclusionOur results expanded the pathogenic genetic and clinical spectrum of BICRA‐related diseases.
Dual‐band coaperture 4G/5G base station antenna array with low scattering elements
Authors: Su Guosheng , Liu Peitao , Yang Wanchen , Xue Quan , Jia Feifei , Li Mingchao , Jiang Wen , Che Wenquan 
Published: July 2023

AbstractA kite‐shaped low‐band (LB) element loaded with mushroom‐shaped structure is proposed. The element has a bandpass characteristic for the electromagnetic wave within the frequency range of 3.4–3.8 GHz and can reduce the influence on the high‐band (HB) antenna in the dual‐band coaperture antenna. The LB elements operating in the 0.698–0.96 GHz frequency band are embedded in the massive multiple input, multiple output (MIMO) antenna. One prototype of the coaperture antenna is fabricated for demonstration. The measured results show that the pattern distortion of most of the antenna ports of the HB antenna is very small after adding the LB antenna. The maximum gain deviation of the traffic beam scanning within the range of ±60° is less than 0.57 dB, indicating that the LB element can effectively suppress scattering and is suitable for multiband coaperture base‐station antenna.
Radiation performance improvement for wideband patch antenna by using characteristic mode analysis
Authors: Cao Yufan , Li Sen , Cai Yang , Wu Tao 
Published: July 2023

AbstractA novel method is proposed to achieve radiation performance improvement for patch antennas by using characteristic mode analysis (CMA). In our previous work, a microstrip patch antenna composed of a driven patch and parasitic square patches was presented to realize wideband performance. To improve the radiation performance, the parasitic patches are replaced with split ring resonators (SRRs). Compared with the previous antenna, the unwanted higher‐order modes of the proposed antenna are effectively suppressed based on the simulated results of CMA, leading to good radiation performance. Meanwhile, wideband performance is maintained as well. Simulated results indicate that these two antennas share similar wide bandwidth more than 30%. However, the gains at the higher resonant frequency for these two antennas are 10.8 and 11.75 dBi, respectively. Finally, measured results show that the bandwidth of SRR loaded antenna is from 10.5 to 15.3 GHz, and the gain varies from 8 to 11.5 dBi across the operating bandwidth.