bluuebunny/crossref_metadata_2025_split huggingface dataset:
The epigenetic Oct4 gene regulatory network: stochastic analysis of different cellular reprogramming approaches
Authors: Bruno Simone , Del Vecchio Domitilla 
Published: March 2023

AbstractIn the last decade, several experimental studies have shown how chromatin modifications (histone modifications and DNA methylation) and their effect on DNA compaction have a critical effect on cellular reprogramming, i.e., the conversion of differentiated cells to a pluripotent state. In this paper, we compare three reprogramming approaches that have been considered in the literature: (a) prefixed overexpression of transcription factors (TFs) alone (Oct4), (b) prefixed overexpression of Oct4 and DNA methylation “eraser” TET, and (c) prefixed overexpression of Oct4 and H3K9me3 eraser JMJD2. To this end, we develop a model of the pluritpotency gene regulatory network, that includes, for each gene, a circuit recently published encapsulating the main interactions among chromatin modifications and their effect on gene expression. We then conduct a computational study to evaluate, for each reprogramming approach, latency and variability. Our results show a faster and less stochastic reprogramming process when also eraser enzymes are overexpressed, consistent with previous experimental data. However, TET overexpression leads to a faster and more efficient reprogramming compared to JMJD2 overexpression when the recruitment of DNA methylation by H3K9me3 is weak and the MBD protein level is sufficiently low such that it does not hamper TET binding to methylated DNA. The model developed here provides a mechanistic understanding of the outcomes of former experimental studies and is also a tool for the development of optimized reprogramming approaches that combine TF overexpression with modifiers of chromatin state.
Satisfaction dimensions influencing consumers’ behavioral intentions through structural topic modeling analysis of restaurant reviews
Authors: Burkov Ivan , Gorgadze Aleksei , Trabskaia Iuliia 
Published: March 2023

Purpose
This study aims to identify the impact of affective components on behavioral intentions applying electronic word of mouth (eWOM) and is based on the “cognitive–affective–conative” model. EWOM allows researchers to get new insights about consumers’ behavior and explores new patterns of consumers’ decision-making processes.

Design/methodology/approach
This study is based on the theory of planned behavior (Ajzen, 1991), doubled with “cognitive–affective–conative” model (Oliver, 2014). This study applies structural topic modeling to examine the impact of satisfaction dimensions from all the Tripadvisor reviews on consumer behavioral intentions. The research sample covers all restaurants located in St. Petersburg (n = 10,424) and all consumers’ reviews (n = 286,642).

Findings
In this study, the dimensions of the affective component were identified. The results demonstrate that dimensions of the affective component (food quality, service quality, atmosphere and cost fairness) affect behavioral intention (willingness to share positive emotions). In total, 20 topics, forming these dimensions, have been indicated. Consumers tend to pay more attention toward food quality and restaurant staffs’ work when they are willing to share positive emotions and tend to point out auxiliary service when they have less willingness to share positive emotions. Random restaurant visits tend to increase the willingness to share positive emotions.

Originality/value
Research originality lies in a new methodological approach which is based on text mining techniques. To the best of the authors’ knowledge, this study is the first attempt to examine consumer behavior through the lens of the “cognitive–affective–conative” model based on eWOM and covers all businesses in the specific economic sphere. This has allowed the researchers to reveal new dimensions of consumer behavior and brought more insights into the consumers’ decision-making process.
Can social interaction-oriented content trigger viewers' purchasing and gift-giving behaviors? Evidence from live-streaming commerce
Authors: Yang Qiang , Huo Jiale , Li Hongxiu , Xi Yue , Liu Yong 
Published: March 2023

PurposeThis study investigates how social interaction-oriented content in broadcasters' live speech affects broadcast viewers' purchasing and gift-giving behaviors and how broadcaster popularity moderates social interaction-oriented content's effect on the two different behaviors in live-streaming commerce.Design/methodology/approachA research model was proposed and empirically tested using a panel data set collected from 537 live streams via Douyin (the Chinese version of TikTok), one of the most popular live broadcast platforms in China. A fixed-effects negative binomial regression model was used to examine the proposed research model.FindingsThis study's results show that social interaction-oriented content in broadcasters' live speech has an inverted U-shaped relationship with broadcast viewers' purchasing behavior and shares a positive linear relationship with viewers' gift-giving behavior. Furthermore, broadcaster popularity significantly moderates the effect of social interaction-oriented content on viewers' purchasing and gift-giving behaviors.Originality/valueThis research enriches the literature on live-streaming commerce by investigating how social interaction-oriented content in broadcasters' live speech affects broadcast viewers' product-purchasing and gift-giving behaviors from the perspective of broadcast viewers' attention. Moreover, this study provides some practical guidelines for developing live speech content in the live-streaming commerce context.
Critical managerial measures on financial risks of sustainable public–private partnership projects: a PRISMA review
Authors: Akomea-Frimpong Isaac , Jin Xiaohua , Osei-Kyei Robert , Pariafsai Fatemeh 
Published: March 2023

Purpose
Public–private partnership (PPP), a project financing arrangement between private investors and the public sector, has revolutionized the approach to the funding and development of public infrastructure worldwide. However, the increasing cases of financial risks and poor financial risk management related to the model threaten the sustainability and financial success of PPP projects leading to huge financial investment losses. This study aims to review existing literature to establish the key measures to control the financial risks of sustainable PPP projects.

Design/methodology/approach
A PRISMA-compliant systematic literature review method was used in this study. Data were sourced from academic databases consisting of 56 impactful peer-reviewed journal articles.

Findings
The review outcomes demonstrate 41 critical factors (measures) in mitigating the financial risks of sustainable PPP projects. They include minimum revenue guarantee, strategic alliance with private investors, financial transparency and accountability and sound macroeconomic policies. The principal results of the study were categorized and conceptualized into a financial risk management maturity model for sustainable PPP projects. Lastly, the study reveals that further studies and project policies must focus more on addressing financial challenges relating to climate risks, and health and safety concerns such as COVID-19 outbreak that have negative impacts on PPP projects.

Research limitations/implications
The results provide essential research gaps and directions for future studies on measures to mitigate the financial risks of sustainable PPP projects. However, this study used small but significant existing publications.

Practical implications
A checklist and a conceptual maturity model are provided in this study to help practitioners to learn and improve upon their practices to mitigate the financial risks of sustainable PPP projects.

Originality/value
This study contributes to managerial measures to reduce huge losses in financial investments of PPP projects and the attainment of sustainability in public infrastructure projects with a financial risk maturity model.
Optimal preventive maintenance policy for leased equipment for free with minimum quantity of consumables purchasing commitment by the lessee
Authors: Tlili Lazhar , Anis Chelbi , Bouazizi Mokhles 
Published: March 2023

PurposeThis paper deals with a particular type of leasing contracts according to which an equipment is leased for free with the condition for the lessee to purchase a predetermined minimum quantity of consumables during each leasing period. Maintenance actions are performed by the lessor and borne by him. Imperfect preventive maintenance is carried out every t time units throughout the leasing period. Minimal repairs are performed following equipment failures. At the end of the leasing period, an overhaul which restores the equipment to “as good as new” state is performed. The equipment is leased many times during its life cycle. The purpose of this paper is to determine the values of the decision variables for the lessor, which are the preventive maintenance (PM) period and the minimum quantity of consumables to be sold to ensure profit.Design/methodology/approachA mathematical model is developed to express the expected maintenance cost per time unit incurred by the lessor as well as his expected profit over the equipment life cycle. The optimal PM period minimizing the maintenance cost is determined first. Then, given the corresponding minimum maintenance cost, the minimum quantity of consumables (the lessor's break-even point) to be purchased by the lessee is computed. A numerical example and a sensitivity study are presented, and the obtained results are discussed.FindingsThe outcome of this work is supposed to help the lessors determining two key values to be included in each leasing contract, namely: (1) the periodicity according to which they will commit to perform preventive maintenance actions such that their average total cost of maintenance is minimized, (2) the minimum quantity of consumables that the lessee must commit to purchasing during the leasing period. This quantity must be between the break-even point and the maximum quantity associated with the capacity of the equipment.Practical implicationsPractically, the objective of this work is first to determine the optimal strategy to be adopted by the lessor in terms of effort relating to PM and second to determine the minimum quantity of consumables that the lessee must purchase during the leasing period such as profit is insured for the lessor.Originality/valueThis type of leasing (for free) has not been addressed in the literature particularly when considering maintenance strategies.
Film-induced tourism – the impact the of animation, cartoon, superhero and fantasy movies
Authors: Florido-Benítez Lázaro 
Published: March 2023

Purpose
The aim of this paper is to analyze the interrelationship between film-induced tourism and visits to theme parks by tourists and examine the most viewed movies worldwide (2010–2022) which are related with theme parks and their attractions.

Design/methodology/approach
The methodology used in this study is a set of qualitative and quantitative indicators for measuring the most visited theme parks worldwide and the most viewed movies that have allowed to answer the research questions.

Findings
This research provides a new contribution to tourism and entertainment industries. Results have shown that film-induced tourism can be the perfect marketing tool to attract more tourists to theme parks through movies and their real or fictional characters represented in films such as Marvel, Minions, Avatar, Harry Potter and Disney, amongst many others. These famous characters are part of theme park’s rides to attract tourists to visit film theme parks These rides allow users to travel in a fantasy experience and interact with film characters of cartoons or fictions. There is a high correlation between film-induced tourism and theme parks’ attractions. Film-induced tourism provides great benefits to the society, theme parks, cinemas and tourist destinations. Indeed, movies help to increase the number of visitors to theme parks. In 2019, 215 million people visited the top 20 theme parks worldwide analyzed in this study, this figure is quite lucrative to entertainment and tourism sectors, local and regional economies where these theme parks are localized.

Originality/value
This study presents the importance of theme parks at tourist destinations because theme parks are an extension of movies, thus is, the end of the physical perfect experience at theme parks which began in a movie seat or on your TV/videogame/PC screens.
The new monies of the startup world: Future‐focused tech ventures as experiments in personal worth
Authors: Chua Emily H.C. 
Published: March 2023

AbstractThe tech startup is a globally admired and emulated form of enterprise, celebrated for its capacity to turn lines of digital code into lean and lucrative businesses. Drawing on recent work in the anthropology of money, I argue that the tech startup's rise is not only leading people to pursue new ways of making money but also giving rise to new constructions of the character and value of money itself. The article follows two startup founders in Singapore – where technocratic state authorities actively encourage citizens to found startup ventures – over three years of developing and marketing their products and attempting to raise investment funds. I show how the founders’ conceptions of the monies at play in their ventures led them to stake not only their economic futures, but also the social and moral worth of their persons on their startup's success. Emerging startup sectors thus draw people into more far‐reaching forms of self‐experimentation than the discourses of entrepreneurial risk and economic reward that surround them let on.
Contingent coordination in crisis: Experiences of Qingdao control command in governing COVID‐19 in China
Authors: Li Yanwei , Song Yunpeng 
Published: March 2023

AbstractCoordination is one of the most challenging crisis management issues governments face worldwide. In this contribution, we examine the coordination mechanism applied by Qingdao control command in China to fight against COVID‐19. Its coordination is implemented contingently via five different approaches: achieving compromises through a centralized tiered meeting system, developing standard operating procedures through issuing documents, encouraging pragmatic problem‐solving through improvisation, establishing routines through finding shortcuts, and following commands and suggestions from higher‐up. Two perspectives, the structural‐institutional and cultural perspectives, have been applied to explain the choice of the contingent coordination mechanism. Our study contributes to the existing crisis coordination literature through substantiating the approaches underlying contingent coordination and providing a preliminary explanation of it.
Intestinal stem cell aging at single‐cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics
Authors: Choi Jiahn , Houston Michele , Wang Ruixuan , Ye Kenny , Li Wenge , Zhang Xusheng , Huffman Derek M. , Augenlicht Leonard H. 
Published: March 2023

AbstractThe intestinal epithelium consists of cells derived from continuously cycling Lgr5hi intestinal stem cells (Lgr5hi ISCs) that mature developmentally in an ordered fashion as the cells progress along the crypt‐luminal axis. Perturbed function of Lgr5hi ISCs with aging is documented, but the consequent impact on overall mucosal homeostasis has not been defined. Using single‐cell RNA sequencing, the progressive maturation of progeny was dissected in the mouse intestine, which revealed that transcriptional reprogramming with aging in Lgr5hi ISCs retarded the maturation of cells in their progression along the crypt‐luminal axis. Importantly, treatment with metformin or rapamycin at a late stage of mouse lifespan reversed the effects of aging on the function of Lgr5hi ISCs and subsequent maturation of progenitors. The effects of metformin and rapamycin overlapped in reversing changes of transcriptional profiles but were also complementary, with metformin more efficient than rapamycin in correcting the developmental trajectory. Therefore, our data identify novel effects of aging on stem cells and the maturation of their daughter cells contributing to the decline of epithelial regeneration and the correction by geroprotectors.
Glutamate levels in the ventromedial prefrontal cortex and resting‐state functional connectivity within reward circuits in alcohol‐dependent patients
Authors: Hu Yiting , Dong Fang , Xue Ting , Zhou Mi , Huang Ruoyan , Sui Feng , Guo Qiang , Hou Wenbao , Cai Wenlong , Yuan Kai , Wang Hongde , Yu Dahua 
Published: March 2023

AbstractGreat progress has been made in understanding the neural mechanisms associated with alcohol‐dependent (AD) patients. However, the interactions within the reward circuits of the patients need further exploration. Glutamatergic projections from the prefrontal cortex to some brain regions are present in the reward circuit. However, little is known about the potential implications of glutamate levels in the prefrontal cortex on abnormal interactions within reward circuits in AD patients. To determine the potential roles of reward circuits in drinking, we investigated differences in resting‐state functional connectivity (RSFC) and multivariate Granger causality analysis between 20 AD patients and 20 healthy controls (HC). The neuroimaging findings were then correlated with clinical variables (alcohol use disorder identification test). The ventromedial prefrontal cortex (VmPFC) is believed to play a critical role in addiction disorders, and glutamatergic projections from the prefrontal cortex to several regions of the brain are present in reward circuits. Proton magnetic resonance spectroscopy was also performed to assess the difference in glutamate levels in VmPFC between AD patients and HC. The results showed that the strength of functional connectivity in the reward circuit was generally attenuated in AD patients, and the reciprocal enhancement of activity between the right insula, left thalamus and VmPFC was found to be significantly greater in AD patients. It is worth noting that although glutamate levels in the VmPFC did not show significant differences between the two groups, the level of glutamate in the VmPFC was significantly correlated with RSFC. We hope that the current findings will help us to develop new intervention models based on the important role of the VmPFC in AD.
RNA sequencing analysis of the longissimus dorsi to identify candidate genes underlying the intramuscular fat content in Anqing Six‐end‐white pigs
Authors: Wang Y. L. , Hou Y. H. , Ling Z. J. , Zhao H. L. , Zheng X. R. , Zhang X. D. , Yin Z. J. , Ding Y. Y. 
Published: March 2023

AbstractIntramuscular fat (IMF) is a significant marker for pork quality. The Anqing Six‐end‐white pig has the characteristics of high meat quality and IMF content. Owing to the influence of European commercial pigs and a late start in resource conservation, the IMF content within local populations varies between individuals. This study analyzed the longissimus dorsi transcriptome of purebred Anqing Six‐end‐white pigs with varying IMF content to recognize differentially expressed genes. We identified 1528 differentially expressed genes between the pigs with high (H) and low (L) IMF content. Based on these data, 1775 Gene Ontology terms were significantly enriched, including lipid metabolism, modification and storage, and regulation of lipid biosynthesis. Pathway analysis revealed 79 significantly enriched pathways, including the Peroxisome proliferator‐activated receptor and mitogen‐activated protein kinase signaling pathways. Moreover, gene set enrichment analysis indicated that the L group had increased the expression of genes related to ribosome function. Additionally, the protein–protein interaction network analyses revealed that VEGFA, KDR, LEP, IRS1, IGF1R, FLT1 and FLT4 were promising candidate genes associated with the IMF content. Our study identified the candidate genes and pathways involved in IMF deposition and lipid metabolism and provides data for developing local pig germplasm resources.
Omalizumab treatment in combination with any other biologics: Is it really a safe duo?
Authors: Koç Yıldırım Sema , Erbağcı Ece , Hapa Aslı 
Published: March 2023

AbstractBackgroundChronic spontaneous urticaria (CSU) is a mast cell‐mediated disease, which is sometimes associated with various inflammatory disorders. Omalizumab is a commonly used biological agent, which is a recombinant, humanized, monoclonal antibody against human immunoglobulin E. However, there are only few reports about the combination of omalizumab for CSU with any other biologics for accompanying inflammatory diseases in the literature. The aim of this study was to evaluate the patients whose treatment of omalizumab for CSU were combined with any other biologics for associated inflammatory disorders and to describe whether these combinations might have any safety concerns.MethodsWe conducted a retrospective cohort study of adult patients with CSU treated with omalizumab concurrently using another biological agent for their other dermatological conditions.ResultsThirty‐one patients, 19 women and 12 men, were evaluated. The mean age was 45.13 years. The median duration of omalizumab was 11 months. Biological agents which patients were treated other than omalizumab were as follows: adalimumab biosimilar (n = 3), ustekinumab (n = 4), secukinumab (n = 17) and ixekizumab (n = 7). The median duration of concurrent use of omalizumab and other biologics was 8 months. None of the drug combinations was stopped because of side effects.ConclusionThis observational study demonstrated that omalizumab treatment for CSU in combination with any other biological agents for dermatological disorders appeared to be well tolerated without any major safety concerns.
Women entrepreneurship: Mumpreneurs cruising the COVID‐19 pandemic in Indonesia
Authors: Tan Jacob Donald , Yew John Lee Kean 
Published: March 2023

AbstractLearning from experiences is key towards the discovery of enterprising knowledge for mumpreneurs in emerging economies such as Indonesia, where most of the entrepreneurship literature is still relatively scant. In discussing entrepreneurial learning of entrepreneurs who are in motherhood, also known as mumpreneurs, these studies require the consideration of gender distinction of women. The term “mumpreneurs” refers to women who embrace the identity of a mother and an entrepreneur, and these two identities engender role conflicts for them. Thus, this phenomenology study explored seven mumpreneurs' experiences of their struggles and strategies to survive the pandemic. The findings shed light on the pandemic impacts and perseverance experiences that mumpreneurs must withstand to maneuver the encountered challenges. This study presents an entrepreneurial learning framework for mumpreneurs by providing pedagogical guidance and inspiration to enable them cruise past future crisis environments. This framework is ultimately crucial in contributing to the ongoing discussions at the academics, practitioners, and policymakers' levels to advise and support mumpreneurial activities that are substantial to the country's economy.