bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hippocampal and neocortical BRAF mutant non‐expansive lesions in focal epilepsies
Authors: Lerond Julie , Mathon Bertrand , Scopin Mélina , Nichelli Lucia , Guégan Justine , Bertholle Céline , Izac Brigitte , Andrieu Muriel , Gareau Thomas , Donneger Florian , Mohand Oumoussa Badreddine , Letourneur Franck , Tran Suzanne , Bertrand Mathilde , Le Roux Isabelle , Touat Mehdi , Dupont Sophie , Poncer Jean Christophe , Navarro Vincent , Bielle Franck 
Published: September 2023

AbstractObjectiveMesial Temporal Lobe Epilepsy‐associated Hippocampal Sclerosis (MTLE‐HS) is a syndrome associated with various aetiologies. We previously identified CD34‐positive extravascular stellate cells (CD34+ cells) possibly related to BRAFV600E oncogenic variant in a subset of MTLE‐HS. We aimed to identify the BRAFV600E oncogenic variants and characterise the CD34+ cells.MethodsWe analysed BRAFV600E oncogenic variant by digital droplet Polymerase Chain Reaction in 53 MTLE‐HS samples (25 with CD34+ cells) and nine non‐expansive neocortical lesions resected during epilepsy surgery (five with CD34+ cells). Ex vivo multi‐electrode array recording, immunolabelling, methylation microarray and single nuclei RNAseq were performed on BRAFwildtype MTLE‐HS and BRAFV600E mutant non‐expansive lesion of hippocampus and/or neocortex.ResultsWe identified a BRAFV600E oncogenic variant in five MTLE‐HS samples with CD34+ cells (19%) and in five neocortical samples with CD34+ cells (100%). Single nuclei RNAseq of resected samples revealed two unique clusters of abnormal cells (including CD34+ cells) associated with senescence and oligodendrocyte development in both hippocampal and neocortical BRAFV600E mutant samples. The co‐expression of the oncogene‐induced senescence marker p16INK4A and the outer subventricular zone radial glia progenitor marker HOPX in CD34+ cells was confirmed by multiplex immunostaining. Pseudotime analysis showed that abnormal cells share a common lineage from progenitors to myelinating oligodendrocytes. Epilepsy surgery led to seizure freedom in eight of the 10 patients with BRAF mutant lesions.InterpretationBRAFV600E underlies a subset of MTLE‐HS and epileptogenic non‐expansive neocortical focal lesions. Detection of the oncogenic variant may help diagnosis and open perspectives for targeted therapies.
Black and male children have an increased risk of palmoplantar psoriasis compared to White children
Authors: Roman Brittany , Collette Sydney , Smith Abigail M. , Theos Amy 
Published: September 2023

AbstractA retrospective chart review of 332 pediatric psoriasis patients seen at a single academic institution from 2012 to 2022 was conducted to examine the risk factors associated with palmoplantar psoriasis (PP), a painful and treatment‐resistant subtype of plaque psoriasis affecting hands and feet. Black patients have a 6.386‐fold increase in the odds of having PP compared to White patients and males have a 2.241‐fold increase in the odds of having PP. Black and Hispanic/Latino patients displayed a higher prevalence of nail and palm/sole involvement (p < .0001), whereas White patients exhibited more scalp involvement (p = .04). This study reveals the importance of considering the diagnosis of PP in Black male patients based on its demographic prevalence, which may in turn impact clinical care for these patients.
Narrative premiums in policy persuasion
Authors: Kawata Keisuke , McElwain Kenneth Mori , Nakabayashi Masaki 
Published: September 2023

AbstractSurvey experiments have shown mixed results about the effect of information provision on attitudes toward controversial policies. We argue that one reason is varied receptiveness to different modes of information. Prior research suggests that people selectively ignore factual, statistical information that contradicts prior beliefs but are more attentive to narrative information that describes individual experiences. We test this in the context of Japanese attitudes toward poverty relief programs, which are less popular than other welfare expenditures. Using a conjoint survey, we show that there is a “narrative premium”: Respondents who are shown a narrative story about the plight of a single mother are more likely to support higher expenditures on poverty relief than those who are shown statistical information about the share of single parents living in poverty. This premium is particularly effective in strengthening the convictions of those who are already aware of levels of societal poverty.
Jumping demands during classical ballet class
Authors: Maloney Brian M. , Mattiussi Adam M. , Cleather Daniel J. , Price Phil , Shaw Joseph W. 
Published: September 2023

AbstractBallet class represents a considerable portion of professional ballet training, yet the external training load demands associated with class—and particularly the jumping demands—have not been investigated. The purpose of this study was to measure the jumping demands of ballet class by sex and rank. Eleven female and eight male elite professional ballet dancers participated in 109 ballet classes taught by 12 different teachers. Jump counts and jump heights were measured during each class. A Poisson generalized linear mixed effects model was used to examine the differences in jump counts between sexes and ranks. Greater jump counts were observed during class in men than in women (153, 95% confidence intervals [CI] [137, 170] vs. 119, 95% CI [109, 131], p = 0.004) and in junior ranking dancers compared with senior ranking dancers (151, 95% CI [138, 165] vs. 121, 95% CI [108, 135], p = 0.006). Female junior and senior ranking dancers jumped at rates of 9.2 ± 2.6 and 8.6 ± 4.7 jumps·min−1, respectively, while male junior and senior ranking dancers jumped at rates of 9.1 ± 2.6 and 8.7 ± 2.6 jumps·min−1, respectively. Across all classes, 73% of jumps observed were below 50% of maximum double‐legged countermovement jump height. Unlike rehearsals and performances, class offers dancers an opportunity to self‐regulate load, and as such, are a useful session to manage jump load, and facilitate gradual return‐to‐dance pathways. Communication between health care and artistic staff is essential to facilitate load management during class.
Design and Fabrication of a Lightweight and Wearable Semirigid Robotic Knee Chain Exoskeleton
Authors: Rivera Diego Martin , Sharifi Mojtaba 
Published: September 2023

Abstract
With the population of people affected by lower limb disability and physical impairments continuing to grow, engineers in response have begun to develop exoskeletons designed to assist and rehabilitate those in need. While there have been great strides and advancements in the development of exoskeletons, many of them are still too cumbersome, heavy, and expensive for most people. The project described in this paper aims to design and manufacture a wearable robotic knee exoskeleton that helps solve some of the drawbacks that exoskeletons have today. The exoskeleton is designed with lightweight and durable three-dimensional (3D)-printed PETG, TPU, and PLA components combined with soft, flexible, and wearable materials to achieve improved human–robot interaction while providing support when bending and extending the knee joint. The three main assemblies designed in this project were a 3D-printed semirigid knee chain, a 3D-printed flexible shin brace, and a motor actuator assembly mounted on a carbon fiber back plate. The semirigid knee chain is actuated using a Bowden cable which allows the heavy motor to be relocated onto the user's back. solidworks topology optimization and finite element analysis (FEA) were used to reduce weight while keeping the overall strength of the chain and ensuring the safety factor of 2. The exoskeleton was observed to be able to withstand applied torques of up to 29 N·m during the walking functionality test. This exoskeleton is also designed to be integrated into a larger hip exoskeleton system.
Toward Development of Novel Remote Ultrasound Robotic System Using Soft Robotics Technology
Authors: Papendorp Sky , Ovando Ammy , Gharaie Saleh , Mosadegh Bobak , Guerra-Zubiaga David , Alaie Seyedhamidreza , Ashuri Turaj , Amiri Moghadam Amir Ali 
Published: September 2023

Abstract
This paper reports on the development of a novel soft robotic system for remote ultrasound applications. Direct contact of the ultrasound probe with the patient's body represents a safety risk and therefore control of the probe's positioning and applied force is a crucial task. The proposed robot uses a passive control system that provides safe interaction between the robot and the patient by leveraging soft robotics technology. The soft robot's structure can be considered as a nonlinear spring which can be designed to exert a safe force within the robot's workspace to guarantee the safety of human–robot interaction. The literature suggests that effective ultrasound imaging of both the heart and abdomen requires six degrees-of-freedom. These degrees-of-freedom consist of three translational motions, which are achieved using a novel hybrid soft cable-driven parallel robot, and three wrist motions, which is based on a universal joint design. The experimental results show that the robot can achieve all these six degrees-of-freedom, and its blocking force can be engineered to generate a uniform force within the workspace.
Development and Validation of Nonhuman Primate Head-Neck Computational Model for Frontal Impact Injury Analysis
Authors: Gerringer Jesse W. , Somasundaram Karthik , Pintar Frank A. 
Published: September 2023

Abstract
Severe cervical spine injuries are rare in an automobile crash, however, the recovery for an individual is difficult. With no suitable surrogate in the laboratory setting, the exact head-neck (HN) response to severe impact accelerations is unknown. Therefore, this study aimed to develop a nonhuman primate (NHP) HN model and validate it using a historic NHP kinematic dataset that tested noninjury, as well as injury-inducing impact accelerations. The geometry of the NHP HN model was constructed from a previously CT-scanned skeleton and idealized as a two-dimensional quadrilateral shell mesh. Inertial properties of the vertebra and skull were defined, as well as 1D beam elements representing the spinal ligaments and discs. The model was then driven at the T1 vertebra using a literature-derived 10G acceleration curve to simulate frontal impact. Output peak Head X-acceleration was measured at 19.8G, which fell within the average peak response of 18.8 ± 4.6 G. Capsular ligament and interspinous ligament strains were measured along the cervical spine and the relative magnitudes were consistent with areas of likely injury at more severe impact accelerations. Once tested at more severe impact accelerations, this NHP HN model will provide a suitable way to study potential human cervical spine dynamics during frontal impact.
Machine Learning Analysis of Autonomous Vehicle Sensors Under Extreme Conditions in Alaska
Authors: Park Jewoo , Quach Nhi V. , Kim Yonghwi , Cheng Ruey-Hwa , Jenco Michal , Yin Chenxi , Lee Alex K. , Won Yoonjin 
Published: September 2023

Abstract
Autonomous vehicles are part of an expanding industry that encompasses various interdisciplinary fields such as dynamic controls, thermal engineering, sensors, data processing, and artificial intelligence. Exposure to extreme environmental conditions, such as changes to temperature and humidity, affects sensor performance. To address potential safety concerns related to sensor perception used in autonomous vehicles in extremely cold real-world situations, specifically Alaska, examination of frosts and water droplets impact on vehicle optical sensors is conducted in both real-world and laboratory-controlled settings. Machine learning models are utilized to determine the vision impediment levels. Potential hardware and software tools are then introduced as solutions for the environmental impacts. Through this research, a better understanding of the potential caveats and algorithm solutions can be suggested to improve autonomous driving, even under challenging weather conditions.
Minimal Number of Events Required for Acceleration–Speed Profiling in Elite Women’s Soccer
Authors: Cormier Patrick , Tsai Ming-Chang , Meylan Cesar , Soares Victor H.T. , Clarke David C. , Klimstra Marc 
Published: September 2023

Purpose: To determine the minimum number of events (training or matches) for producing valid acceleration–speed (AS) profiles from global navigation satellite system (GNSS) data. Methods: Nine elite female soccer players participated in a 4-week training camp consisting of 19 events. AS profile metrics calculated from different combinations of athlete events were compared to force–velocity (FV) profile metrics from 2 × 40-m stand-alone sprint effort trials, using the same GNSS 10-Hz technology. Force–velocity profiles were calculated, from which AS profiles were obtained. AS profiles from training and matches were generated by plotting acceleration and speed points and performing a regression through the maximal points to obtain the AS metrics (theoretical maximal speed, x-intercept [in meters per second], theoretical maximal acceleration, y-intercept [in meters per second squared], and the slope per second). A linear mixed model was performed with the AS metrics as the outcome variables, the number of events as a fixed effect, and the participant identifier as a mixed effect. Dunnett post hoc multiple comparisons were used to compare the means of each number of event grouping (1–19 events) to those estimated from the dedicated sprint test. Results: Theoretical maximal speed and theoretical maximal acceleration means were no longer significantly different from the isolated sprint reference with 9 to 19 (small to trivial differences = −0.31 to −0.04 m·s−1, P = .12–.99) and 6 to 19 (small differences = −0.4 to −0.28 m·s−2, P = .06–.79) events, and the slopes were no longer different with 1 to 19 events (trivial differences = 0.06–0.03 s−1, P = .35–.99). Conclusions: AS profiles can be estimated from a minimum of 9 days of tracking data. Future research should investigate methodology resulting in AS profiles estimated from fewer events.
Tracking District and School Physical Education Time Policies After Legal Adjudication: A Case Study in California
Authors: Kahan David , McKenzie Thomas L. , Satnick Maya , Hansen Olivia 
Published: September 2023

Purpose: Studies tracking changes in physical education (PE) policy adherence after an intervention are scarce. In California, successful litigation against 37 school districts for not providing adequate PE time compelled district schools’ teachers to post PE schedules online or on-site for 3 years. We performed a follow-up study 4 years after the expiration of lawsuit settlement stipulations to determine the level of adherence in the absence of external accountability. Methods: We reexamined the websites of all 37 school districts, 106 schools’ websites that posted time information in spring 2018 (Time 1), and a proportionate 20% random sample of schools’ websites (n = 150) that posted no information at Time 1. We used descriptive statistics and paired t tests to detect differences between Times 1 and 2. Discussion/Conclusion: District websites mostly maintained postings of PE time documents and information, while the proportion of Time 1 posting school websites with such content dropped by 58%–67%. At the school level, compliance to policy mandates was positively, but not permanently impacted by a lawsuit intervention.
Transverse momentum and multiplicity dependence of $$\varLambda _{c}^{+}/D^{0}$$ ratio in pp collisions at $$\sqrt{s}=13$$ TeV
Authors: Song Jun , Li Hai-hong , Shao Feng-lan 
Published: September 2023

AbstractWe apply an equal-velocity quark combination model to study the $$\varLambda _{c}^{+}/D^{0}$$

Λ

c

+

/

D
0

ratio in the range $$p_{T}\lesssim 10$$

p
T

≲
10

GeV/c in pp collisions at $$\sqrt{s}=13$$

s

=
13

TeV. We decompose the ratio into four parts which are related to quark numbers, light-flavor quark $$p_{T}$$

p
T

spectrum, charm quark $$p_{T}$$

p
T

spectrum, momentum correlation between light and charm quarks, respectively. Their influence on $$\varLambda _{c}^{+}/D^{0}$$

Λ

c

+

/

D
0

ratio is individually studied. The curvature property of light-flavor quark $$p_{T}$$

p
T

spectrum is the main reason of the non-monotonic $$p_{T}$$

p
T

dependence of $$\varLambda _{c}^{+}/D^{0}$$

Λ

c

+

/

D
0

ratio exhibited in high multiplicity events. Moreover, the multiplicity dependence of $$\varLambda _{c}^{+}/D^{0}$$

Λ

c

+

/

D
0

ratio as the function of $$p_{T}$$

p
T

is mainly because of the multiplicity dependence of light-flavor quark $$p_{T}$$

p
T

spectrum. Using the light-flavor quark $$p_{T}$$

p
T

spectrum obtained from experimental data of light-flavor hadrons and charm quark $$p_{T}$$

p
T

spectrum obtained from FONLL and/or PYTHIA calculations, the $$p_{T}$$

p
T

dependence of experimental data of $$\varLambda _{c}^{+}/D^{0}$$

Λ

c

+

/

D
0

ratio in high multiplicity events and that in low multiplicity events in pp collisions at $$\sqrt{s}=13$$

s

=
13

TeV are reasonably understood.
Muses as ‘Fellow Citizens’?
Authors: Mojsik Tomasz 
Published: September 2023

Abstract
In line 1 of the so-called Seal (118 AB), Posidippus invokes Μοῦσαι πολιήτιδες (‘Muses fellow citizens’). This fact has puzzled scholars for years, as the Muses are nowhere else referred to as such. Referring to an epigram of Queen Eurydice, a dedication in honour of the Muses from the Pella area as well as evidence of cultural activity in the Macedonian capital, I demonstrate that the term πολιήτιδες used in the poem is related to the poet’s hometown. I also illustrate that naming the Muses ‘fellow citizens’ and placing their statues in the agora, theatre or gymnasion reflected the central position of mousikē, education and literature, in Greek culture. In addition, I draw a parallel with the phenomenon of honouring poets with statues at central points in the city, often surrounded by the Muses.
Niche evolution and diversification in Middle Eastern stream salamanders (Paradactylodon): vulnerability to future climate change
Authors: Vaissi Somaye , Heshmatzad Pouria , Hernandez Axel 
Published: September 2023

Abstract
The relict genus Paradactylodon is narrowly distributed in temperate forests throughout the Middle East region, including P. mustersi in Afghanistan, P. persicus, and P. gorganensis in northwestern and northeastern Iran. Recent phylogenetic analyses suggest that the Iranian Paradactylodon populations may belong to a single species, P. persicus. In this study, we addressed how climatic niche conservatism and/or niche divergence may have affected the evolution of all Paradactylodon species using ecological niche models and multivariate niche analyses to identify niche overlap and assess equivalency and similarity tests. We also used an ensemble of ten algorithms to predict Paradactylodon species distributions for recent (1970-2000) and future (2081-2100) climate conditions. The results show that future climate change may cause the loss of 80 to 97% of these species’ suitable habitat, especially at lower elevations. The niche divergence hypothesis was supported by the results of niche equivalency tests on P. persicus vs. P. gorganensis (and vice versa) with moderate overlap (D = 0.23, I = 0.41) and P. persicus vs. P. mustersi (and vice versa) with little overlap (D = 0.05, I = 0.06). Meanwhile, the niche similarity test for the niche conservatism hypothesis revealed significant results for P. persicus vs. P. gorganensis, P. mustersi vs. P. persicus, and P. persicus + P. gorganensis (as a single species) vs. P. mustersi. Due to these complex evolutionary ecological patterns and allopatric distributions, we recommend that P. gorganensis be considered a valid subspecies.
Following the Pipeline
Authors: Olszok Charis 
Published: September 2023

Abstract
Contributing to the fields of eco- and petro-criticism, this article argues for significant connections in the Arabic novel between fantastical and uncanny aesthetics, on the one hand, and ecological awareness and energy anxiety on the other. Moving from nation-based comparisons, in recognition of how energy ecologies similarly traverse sovereign borders, it does so through Iraqi author Fāḍil al-ʿ⁠Azzāwī’s Ākhir al-malāʾikah (1992) and the Palestinian Imīl Ḥabībī’s Sarāyā, bint al-ghūl (1991). Set at either end of the Kirkuk-Haifa oil pipeline, in their authors’ home cities, these novels were completed within a few weeks of one another, during the first months of the petroleum-driven Gulf War (1990–1991), to which they allude. Through phantoms, jinn, angels, and zombies, they dramatize the emotional, environmental, and social disturbances of petro-modernity.
Sophoclean Epistemology: Justice in the Theban Plays
Authors: Hunnisett Gillian , MacDonald Sara 
Published: September 2023

Abstract
In Oedipus at Colonus Sophocles shows that neither individual reason nor piety are singularly sufficient for either individual happiness or the common good. Human understanding is dependent on a decentering of the individual, such that the reason of the wider community, including that of the gods, can augment the limitations of individual perspective. Sophocles shows not only the dependence of faith and reason on one another, but the degree to which both are dependent on reciprocal good will within a community.
Persistent Dissent and Plato’s Later Theory of Civic Participation
Authors: Bartninkas Vilius 
Published: September 2023

Abstract
Plato in the Laws proposes a simulation of nearly ideal conditions regarding the experts’ persuasion and observes that even in these circumstances some citizens will not agree with the epistemic authorities. In this paper, such situations are labelled as exhibiting persistent dissent. Plato maintains that persistent dissenters lack the virtue of sōphrosynē, but its meaning is notoriously difficult to decipher. This paper offers to examine the role of sōphrosynē in tackling persistent dissent in light of Plato’s reflections on civic participation. This angle will not only uncover the epistemic aspect of sōphrosynē that lays the groundwork for persuasion, but it will also give a less optimistic assessment of the civic theory of the Laws, whilst simultaneously widening our own understanding of the range of disagreements between the experts and the non-experts and the difficulties in removing them.
Mining Plato’s Cave: Silver Mining, Slavery, and Philosophical Education
Authors: Bakewell Geoffrey 
Published: September 2023

Abstract
The Allegory of the Cave (Pl. Resp. 514a1–520e2) is often analyzed in terms of metaphysical, epistemological, political, and psychic hierarchies that are clarified and reinforced by philosophical education. But the Allegory also contains an important historical allusion to the silver mining that took place in classical Attica. Examining the Cave in light of the enslaved miners around Lavrio leads us to reconsider the philosophical ‘liberation’ (λύσιν … τῶν δεσμῶν, 515c4) at the Allegory’s heart in the context of Athenian slavery and Plato’s thoughts on the practice. Elsewhere in his work Plato generally uses servile metaphors in two ways: to depict ‘bad’ internal psychic subjection and ‘good’ submission to logos as manifested in various entities. This historical dimension of the Allegory works to undermine the ostensible naturalness of the slave/citizen distinction and suggest that philosophical education has the potential to ‘free’ the former and ‘subjugate’ the latter. The implication that these juridical categories are, to an extent, arbitrary and mutable reveals important differences between Plato’s views and those of his classical peers, and it adds to the dialogue’s protreptic dimension for its readers then and now.