bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE RELATIONSHIP BETWEEN SERUM GALECTIN-3 LEVEL AND CAROTID FEMORAL PULSE WAVE VELOCITY IN PATIENTS WITH ACROMEGALY
Authors: Ozturk Huseyin Ali , Sumbul Hilmi Erdem 
Published: June 2023

Objective:
To the best our knowledge, there are no studies showing the relationship between galectin-3 level and carotid femoral pulse wave velocity (CF-PWV) in acromegaly and more studies are needed. We aimed to investigate the relationship between galectin-3 level, which is thought to change due to early inflammation and atherosclerosis, and CF-PWV in patients with acromegaly.

Design and method:
In our study, forty patients between the ages of 18 and 65 who were diagnosed with acromegaly in Adana City Training and Research Hospital and 40 healthy controls were included. Insulin-like growth factor-1 (IGF-1), GH levels, hemogram and biochemistry values of the patients were evaluated. Galectin-3 level was measured using Human galectin-3 kits and Enzyme-Linked Immuno Sorbent Assay method. CF-PWV measurements of the patients were performed using doppler ultrasonography and simultaneous electrocardiography.

Results:
In our study; we found that galectin-3 level, which is an indicator of fibrosis and inflammation, and CF-PWV, which is the gold standard indicator of arterial stiffness, were higher in the acromegaly patient group than in the control group and were statistically significant. In correlation analysis, we found that serum galectin-3 level was associated with IGF-1 level and CF-PWV measurements. In the linear regression analysis, we found that the level of IGF-1 was independently associated with galectin-3 level.

Conclusions:
Galectin-3 may be a new diagnostic, prognostic biomarker and a new promising therapeutic target for cardiovascular disease development in patients with acromegaly. Galectin-3 level and CF-PWV measurement can be used to detect and predict cardiovascular disease in acromegaly patients at an early stage.
PULSE WAVE VELOCITY 8.2 M/S AS A THRESHOLD ASSOCIATED WITH CARDIOVASCULAR TARGET ORGAN DAMAGE
Authors: Inuzuka Sayuri , Vitorino Priscila , Camargo Adriana , Magalhaes Fabricio , Sousa Andrea , Alves Robson , Melo Victoria , Mesquita Gustavo , Valle Deborah , Silva Eduarda , Sousa Ana , Coca Antonio , Jardim Paulo Cesar , Sebba-Barroso Weimar 
Published: June 2023

Objective:
Identify from which PWV value, there is a greater possibility of identifying association with the presence of left ventricular hypertrophy (LVH), increased intima-media thickness (IMT) and presence of carotid plaque in hypertensive patients.

Design and method:
This is a cross-sectional study of 119 patients. ROC curves were performed for each cardiovascular biomarker. The analyses were performed considering the significance level of 0.05.

Results:
ROC curves were performed for each cardiovascular biomarker and the PWV values of 8.1m/s for LVH, 8.2m/s for increased IMT and 8.7 for the presence of carotid plaque were found, respectively. The PWV value of 8.2m/s identified the best parameter to find the three TOD outcomes. PWV above 8.2ms was associated with increased IMT (p = 0.004), with the presence of carotid plaque (p = 0.003) and with LVH (p<0.001). PWV above 8.2 showed greater sensitivity for IMT (AUC = 0.678, sensitivity 62.2), LVH (AUC = 0.717, sensitivity 87.2) and presence of plaque (AUC = 0.649, sensitivity 74.51) in the ROC curve.

Conclusions:
The 8.2m/s value is more sensitive in identifying the existence of cardiovascular biomarkers prematurely.
NOVEL BIOMARKERS OF KIDNEY CELL PATHOLOGY, INFLAMMATION AND FIBROSIS IN CONTROLLED AND UNCONTROLLED HYPERTENSION
Authors: Brobak Karl Marius , Halvorsen Lene Vernås , Aass Hans Christian D. , Høieggen Aud , Liestøl Knut , Norvik Jon Viljar , Blom Kjersti B. , Birkeland Jon Arne Kro , Søraas Camilla Lund , Bergland Ola Undrum , Aune Arleen , Olsen Eirik , Rognstad Stine , Hjørnholm Ulla , Kjær Vibeke Norheim , Rostrup Morten , Larstorp Anne Cecilie K , Solbu Marit Dahl 
Published: June 2023

Objective:
A significant reduction in kidney function is needed to detect a decrease in estimated glomerular filtration rate (eGFR), and only a minority of patients with hypertension (HT) have elevated urinary albumin excretion (UAE), leaving these biomarkers insensitive for early hypertensive organ damage. Low-grade inflammatory processes and fibrosis may have a key role in the pathogenesis of HT and HT-mediated kidney damage. Finding a panel of biomarkers related to HT and kidney damage at an early stage, that varies with modifiable risk factors, may aid targeted treatment. Several biomarkers of kidney cell pathology, markers of inflammation and fibrosis are of interest.
In this nationwide cross-sectional multicentre study, we aimed to assess the associations between biomarkers and hypertension in four groups of patients; (1) healthy controls, (2) controlled HT, (3) uncontrolled HT, (4) uncontrolled HT with presence of kidney damage based on UAE and eGFR. We hypothesized that: (1) plasma levels of biomarkers are different between the 4 groups, (2) plasma levels of biomarkers are associated with the different HT groups.

Design and method:
Hypertensive patients (n = 183) were > = 18 years old with eGFR >30 mL/min/1.73m2, prescribed > = 2 antihypertensive agents and on a stable treatment regimen for at least 4 weeks. Age and sex matched healthy controls had undergone kidney donation assessment (n = 39). Biomarkers were analyzed in duplicate by a custom made Luminex bead-based immunoassay. The ethics committee approved the studies. All patients signed written informed consent.

Results:
Plasma levels of IL-1RA, NGAL and uromodulin were significantly different between healthy controls (n = 39) and hypertensive patients (n = 183). Levels of IL-1RA and NGAL were significantly different between the three groups of hypertensive patients. In multivariable models on hypertensive subjects none of the biomarkers were associated with uncontrolled HT (n = 126). IL-18, vWF-A2, NGAL and uromodulin were associated with uncontrolled HT with presence of kidney damage (n = 65). None of the biomarkers were associated with any of the HT groups after adjustment for eGFR.

Conclusions:
Selected biomarkers may add information to identify hypertensive patients at risk for kidney damage, but further and longitudinal analysis are needed.
DECREASED SERUM LEVELS OF IRISIN PREDICTED HEART FAILURE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Berezin Alexander , Fushtey Ivan , Berezin Alexander 
Published: June 2023

Objective:
Type 2 diabetes mellitus (T2DM) is a powerful risk factor for heart failure (HF) contributing to untoward clinical course of the condition. Although natriuretic peptides are validated biomarkers to rule out HF, the accuracy of them in prediction of HF in T2DM is not optimal. The aim of the study was to investigate whether serum irisin has additional discriminative capacity for HF in patients with T2DM.

Design and method:
We prospectively included 183 T2DM patients with aged 41 to 65 years (153 patients with any phenotypes of HF and 30 patients without HF) in the study. The following criteria such as age > 18 years, established T2DM regardless of HF, and the levels of HbAc1 less 6.9% were used as inclusion ones. All patients underwent general examination, echocardiography and Doppler. The plasma levels of NT-proBNP and irisin were measured using ELISA

Results:
The Receive Operation Characteristics curve analysis showed that the well-balanced cut-off point for serum concentration of irisin (HF vs non-HF) were 10.4 ng/mL (area under curve [AUC] = 0.96 (95% CI = 0.88 – 1.00), sensitivity = 81.0%, specificity = 88.0%; P = 0.0001). Cutoff point of NT-proBNP (HF vs non-HF) was 750 pmol/L (AUC = 0.96; 95% CI = 0.59 - 0.98; sensitivity = 72.7%, specificity 76.5%, p = 0.0001). Multivariate logistic model yielded that the serum levels of irisin < 10.4 ng/mL (OR = 1.30; P = 0.001) and NT-proBNP > 750 pmol/mL (OR = 1.17; P = 0.042), left atrial volume index (LAVI) > 34 mL/m2 (OR = 1.06; P = 0.042) remained to be strong predictors for HF, whereas LAVI did not. Add-on of irisin levels < 10.4 ng/mL to the predictive model constructed from NT-proBNP (> 750 pg/mL) significantly improved discriminatory potency of the whole model for HF.

Conclusions:
We found that decreased serum levels of irisin significantly predicted HF in T2DM patients. This finding may open a new approach for HF risk stratification in T2DM patients.
CONCENTRATION OF CYSTATIN C AND ITS RELATIONSHIP WITH DAILY BLOOD PRESSURE MONITORING INDICATORS IN PATIENTS WITH ESSENTIAL HYPERTENSION
Authors: Ivankova Anastasiia , Kuzminova Nataliia 
Published: June 2023

Objective:
Cystatin C (CysC) acts as an early and most informative marker of renal dysfunction. It has been proven that the indicator is a more sensitive marker of a decrease in glomerular filtration rate than creatinine.
Aim. To evaluate changes of cystatin C concentration and its relationship with daily blood pressure monitoring indicators in patients with hypertension.
Materials and methods. The study included 156 patients with stage II essential hypertension (EH) and 30 people without any cardiovascular pathology. All patients underwent an examination, which included: 1) general clinical examination; 2) ECG; 3) daily blood pressure monitoring (DM BP); 4) level of CysC.
The results. To form analysis groups based on the level of cystatin C, 3 categories of patients were conventionally selected: 1st - with a conditionally low (CL) level, 2nd - with an intermediate level, and 3rd - conditionally high (CH) level of CysC in the examined sample of patients with EH.
Having evaluated DM BP indicators depending on the level of CysC, it can be asserted that the average values of systolic and pulse BP at night were significantly higher in patients with a CH level of CysC, which was significantly different from the corresponding values in patients with intermediate and CL levels of CysC (148 vs. 140 and vs. 139 mm Hg, p<0.03; 70 vs. 60 and against 59 mm Hg, respectively, p<0.02). The analysis of the circadian regulation showed fundamental differences only in the daily profile of the night-peaker. 22.5% of patients with a CH level of CysS had nocturnal hypertension, which was significantly different from patients with an intermediate level of the indicator, which was 7.9% (p = 0.03).
Conclusions. A relatively high level of cystatin C (more than 1.37 mg/l) was associated with higher BP values, higher frequency of night-peaker. An intermediate level of cystatin C (1.00-1.37 mg/l) was associated with a higher frequency of registration of a non-dipper daily profile on BP. A relatively low level (less than 1.00 mg/ml) was associated with a higher frequency of registration of the daily profile dipper.
PHYSICAL AND BIOCHEMICAL RISK FACTORS OF HYPERTENSION: FINDINGS FROM MULTI-SITED POPULATION-BASED STUDY FROM INDIA
Authors: Devi Naorem Kiranmala 
Published: June 2023

Objective:
Studies have shown variations in the degree of association between hypertension and its risk factors in different populations. Both genetic and environmental factors are thought to play roles in modulating the relationship between hypertension and its physical and biochemical risk factors/markers. The present study aims to investigate the association of hypertension with body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density density lipoprotein (VLDL), and apolipoprotein B (Apo B) in three tribal (Liangmai, Mizo, and Bhil) and two non-tribal (Jat and Meitei) populations of India.

Design and method:
The present study is an outcome of four cross-sectional studies undertaken among three tribal, Liangmai (n = 339), Mizo (n = 269) and Bhil (n = 407), and two non-tribal, Jat (n = 1447) and Meitei (n = 1142), populations of India (total sample size = 3604). Recruited participants were adults (age range 18-86 years; mean age = 47.3±11.0 years) of both sexes (55.5% females). Socio-demographic data was collected using a pretested and modified interview schedule. Height, weight, waist and hip circumference, and hypertension were measured using standard techniques. Hypertension was defined as per ACC/AHA High Blood Pressure Guidelines. Values of TC, TG, and HDL levels were obtained using commercial kits (Randox, USA) through spectrophotometry. Values of LDL, VLDL, and Apo B were calculated. Statistical analysis was performed using SPSS version 22.

Results:
The overall prevalence of hypertension stage-1 and stage-2 was found to be 37.9% and 34.0%, respectively. The highest prevalence of hypertension (stage-1+sage-2) was found in Meitei community and the lowest in the Bhil community. Studied physical and biochemical risk factors showed variations in the degree of association with hypertension in different populations. Of the studied risk factors, BMI and WC showed most consistent and statistically significant positive association with systolic and diastolic blood pressure. Though hypertension was found to be associated with some of the lipid variables in some populations, the pattern was not consistent across populations.

Conclusions:
The study suggests that physical variables (BMI and WC) may be better markers of hypertension than biochemical variables.
IMPACT OF OSCILLOMETRIC MEASUREMENT ARTEFACTS IN AMBULATORY BLOOD PRESSURE MONITORING ON ESTIMATES OF AVERAGE BLOOD PRESSURE AND OF ITS VARIABILITY: A PILOT STUDY
Authors: Bothe Tomas L. , Bilo Grzegorz , Parati Gianfranco , Haberl Ralph , Pilz Niklas , Patzak Andreas 
Published: June 2023

Objective:
Ambulatory blood pressure monitoring (ABPM) plays an important role in the diagnosis of hypertension. However, methodological factors and the measurement conditions affect the results and may lead to incorrect classification of the patient. We performed a pilot study to evaluate the impact of oscillometric measurement artefacts on ABPM-derived variables.

Methods:
Four classes of artefacts have been detected: motor activity artefacts, cuff errors, cardiovascular arousals, and arrhythmias. These artefacts were identified via simultaneous recording of actigraphy, cuff pressure, and an ECG. The data consisted of uncorrected measurements (all data), corrected measurements (all artefact free data), and artefact affected data.

Design and method:
A total of 30 individuals (9 female / 21 male, aged between 36 and 86 years, mean: 65.5 (SD: 9.5) were included in the study. The 24h average blood pressure (BP) was higher in artefacts-affected measurements compared the artefact-free measurements both for systolic (4.6 mmHg) and diastolic (1.3 mmHg) measurements. Further, artefact-affected systolic BP (SBP) was 6.4 mmHg higher than artefact-free measurements during daytime. On average, nocturnal measurements showed no artefact-depended differences. However, individual comparisons yielded that 23% of the subjects crossed the threshold for BP classification for either 24-h, daytime or nocturnal hypertension when comparing uncorrected and artefact-free measurements. Dipping classification changed in 24% of subjects. BP variability was 21% and 12% higher for SPB and DBP, respectively, during daytime when comparing uncorrected and artefact-free measurements. These differences were even higher (27% for SBP and 21% for DPB) when focussing on night-time BP variability.

Conclusions:
The study reveals that measurement artefacts are frequently present during cuff-based ABPM and do relevantly affect measurement outcome. Exclusion of measurement artefacts is a promising approach to improving cuff-based ABPM accuracy.
VISUAL ASSESSMENT OF KOROTKOFF SOUNDS FURTHER IMPROVES THE ACCURACY OF A VALIDATED PROFESSIONAL AUTOMATED AUSCULTATORY BLOOD PRESSURE MONITOR – INBODY BPBIO480KV
Authors: Ntineri Angeliki , Menti Ariadni , Theodosiadi Aikaterini , Ntousopoulos Vasileios , Stathopoulou Panagiota , Kyriakoulis Konstantinos , Kollias Anastasios , Stergiou George S. 
Published: June 2023

Objective:
A novel automated auscultatory upper-arm cuff blood pressure (BP) monitor for office use (InBody BPBIO480KV, Seoul, S Korea) has been recently validated, which allows healthcare professionals to visually review the Korotkoff sounds curves generated for each BP reading. This study investigated whether this feature could further improve the accuracy of the device by identifying unreliable BP readings.

Design and method:
Three observers assessed independently the morphology of Korotkoff sound curves generated during a validation study according to the ISO 81060-2:2018 standard, and classified them as having good, fair, or poor signal quality (low signal amplitude or sound intensity, aberrant signal morphology, interference of background noise or other signal artifact, presence of auscultatory gap, or irregular rhythm), separately for the systolic and diastolic BP area. The observers were blinded to the automated and the reference BP measurement results. Disagreement among observers was resolved by a supervisor. Factors associated with poor quality signal were also investigated.

Results:
A total of 255 Korotkoff sound curves (test BP readings) by 85 participants (mean age 57.3±15.0 years, 53 men) were analyzed. For systolic BP, 82.0/12.2/7.5% were classified as good/fair/poor quality and for diastolic 76.9/12.2/11.0%. Inter-observer agreement in detecting poor quality curves was 84.7/83.1% (systolic/diastolic). Of poor quality curves 10.5/60.7% (systolic/diastolic) clustered in the same individuals. Young age and female sex increased the odds for poor quality signal. ISO validation Criterion 1 (mean BP difference ±SD) was satisfied for readings with good (0.1±4.9/0.3±3.8 mmHg, systolic/diastolic) and fair (-0.4±6.4/0.2±5.0) quality curves, good/fair quality curves (0.1±5.1/0.2±4.0 mmHg, systolic/diastolic), but not for those with poor quality signal (2.7±8.8/3.6±8.1 mmHg). In the ISO validation study, excluding readings with poor quality signal (systolic and/or diastolic area; 40 of 255) Criterion 1 was improved (0.2±4.9/0.2±3.9 mmHg versus 0.3±5.5/0.6±4.7 mmHg).

Conclusions:
The visual assessment of Korotkoff sounds generated by automated auscultatory BP measurement using the InBody BPBIO480KV professional office BP monitor is useful in identifying unreliable readings and further improves the device accuracy.
POOR AGREEMENT BETWEEN CAROTID-FEMORAL PULSE WAVE VELOCITY (C-F PWV) AND 24 HOUR PWV DETERMINED WITH TWO DIFFERENT METHODS
Authors: Prelevic Vladimir , Jelakovic Ana , Radunovic Danilo , Gallineo Lana , Domislavic Marija , Gasparovic Kristina , Josipovic Josipa , Jelakovic Bojan 
Published: June 2023

Objective:
The gold standard of arterial stiffness determination is measurement of the carotide-femoral pulse wave velocity (cf-PWV). It was suggested that 24 hour measurement might give addition or more insights in the estimation of the global cardiovascular (CV) risk
Our aim was to analyze association/concordance between cf-PWV values (SphygmoCor) with the values obtained with 24h measurments (Mobil-o-Graph and Arteriograph).

Design and method:
This study included 154 patients with the primary hypertension (women 69.5%, mean age 38.5). In all of them we collected various clinical and laboratory data and antroplogical paramaters. Parameters of arterial stiffness were measured with the SphygmoCor and 24h using Mobil-o-Graph and Arteriograph devices during the regular working day. Concordance correlation coefficient (CCC) was calculated. the Bland Altman method was used to estimate the deviation of methods Limits of agreement (LoA) are defined as the mean difference ± 1.96 SD difference.

Results:
Statistically significant correlation was observed between cf-PWV and data obtained with Arteriograph: 24h, day, night; and Mobilograph: 24h, day and night (r = 0.500, p < 0.001; r = 0.485, p < 0.001; r = 0.519, p < 0.001); r = 0.697, p < 0.001, r = 0.691, p < 0.001) r = 0.665, p < 0.001, respectively). cf-PWV shared 25% and 49% of the variance (R2) with the Arteriograph and Mobilograph, respectively. CCC was weak for both methods, Arteriograph and Mobilograph (CCC 0.49 95%CI 0.36-0.60; 0.50 95% CI 0.41-0.58, respectively). Large difference was observed for both methods, being larher for Arteriograph than with Mobilograph (-0.31 m/s (LoA -4.8 to 4.8) ; 1.6 m/s (LoA -1.69 to 4.89, respectively).

Conclusions:
In the group of young treated hypertensive patients with mild CV risk we found week agreement between cf-PWV and 24h PWV data. Better concordance was found between cf-PWV and Mobilograph than with Arteriograph. It could be concluded that cf-PWV and 24h PWV could not be used intercheangable. More results are needed to answer whether 24 h PWV has the same clinical value as cf-PWV
DAYTIME BLOOD PRESSURE MEASUREMENTS PERFORMED BY AKTIIA CUFFLESS MONITOR AND 24-H AMBULATORY BLOOD PRESSURE MONITOR: PRELIMINARY COMPARATIVE RESULTS OF A SINGLE-CENTRE STUDY
Authors: Almeida Tiago Paggi de , Cortés Meritxell , Perruchoud David , Alexandre Jérémy , Vermare Pascale , Sola Josep , Shah Jay , Marques Luisa , Pellaton Cyril 
Published: June 2023

Objective:
Ambulatory blood pressure (BP) monitors (ABPM) measure systolic and diastolic BP (SBP, DBP), limited to 24-48-hour snapshots, using uncomfortable cuff-based oscillometric sphygmomanometers. Some cuffless BP devices overcome these limitations, supporting continual BP monitoring. However, there is intense debate whether cuffless devices generate data comparable to ABPM. Here, we present preliminary results of daytime BP measurements performed by Aktiia cuffless BP monitor (Aktiia SA, Switzerland) compared to 24-hour ABPM.

Design and method:
52 out of 63 estimated total patients (NCT04548986, age 53.2±7.1 years, 18.9% female, arm circumference 28.5±2 cm) had been enrolled in a 12-week cardiac rehabilitation (CR) program (Réseau Hospitalier Neuchâtelois, Switzerland). The patients used the Aktiia monitor during the entire CR program, while 24-hour ABPM (Dyasis 3, Novacor, France) was performed on the first and last day of the CR program. For each patient, average daytime (9am-9pm) SBP and DBP were calculated – and compared – for 1 day of ABPM and 7 days of Aktiia monitor (session 1: ABPM first day vs. Aktiia first week; session 2: ABPM last day vs. Aktiia last week). Only sessions that had 20 or more valid daytime measurements on both modalities were included in the study.

Results:
50 patients (35 in session 1, 15 in session 2) had 20 or more valid daytime measurements on both modalities, and were included in the study. Bias between Aktiia monitor and ABPM for daytime DBP was (mean ± SD [95% CI]) -2.2±8.0 [-4.5, 0.1] mmHg (Figure 1A), with agreements of 78% and 96% within ±10 mmHg (dark grey) and ±15 mmHg (light grey) regions of interest (ROI), respectively. Bias between Aktiia monitor and ABPM for daytime SBP was 1.6±10.5 [-1.5, 4.6] mmHg (Figure 1B), with agreements of 60% and 84% within the ±10/±15 mmHg ROI, respectively.

Conclusions:
The results suggest that 1-week Aktiia monitor yields equivalent daytime BP values to 24-h ABPM, which supports the use of Aktiia monitor for long-term, continual daytime BP monitoring. The present preliminary study is limited by the partially recruited population and daytime measurements only. Night-time analysis will be covered in subsequent studies.