bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linked bicontinuity of posets of compact ultrapseudometrics
Authors: Nykyforchyn Oleh , Nykorovych Svyatoslav 
Published: August 2023

Abstract
Approximation relations (``way below'' and ``way above'') onpointwise ordered sets of ultrapseudometrics are studied. It isproved that, to obtain continuity and/or dual continuity of theseposets in the sense considered in domain theory, i.e., possibilityto ``safely'' approximate all elements from below and from aboverespectively, one should restrict to compact ultrapseudometrics,not exceeding a fixed one. Such poset is a complete lattice,the partial order on it determines the Lawson topology and the dualLawson topology, which coincide (which is linked bicontinuity), arecompact Hausdorff, and agree with the uniform convergence metric.Necessary and sufficient conditions are proved for ``way below''and ``way above'' relations to hold.
MSC Classification: 06F30 , 54E35
Ecology of extremely female-biased pest insect Hyperlasion breviantenna Sueyoshi et al., 2022 (Diptera: Sciaridae) occurring as outbreaks
Authors: Tagami Yohsuke , Ishihara Yuki , Ohata Yuta , Tsushima Yusuke , Sueyoshi Masahiro 
Published: August 2023

Abstract
Since approximately 2004, outbreaks of the sciarid species Hyperlasion breviantenna Sueyoshi et al., 2022, have occurred at Shizuoka University, Shizuoka, Japan. We attempted to identify the reason for the outbreaks through ecological research. According to the results of our investigation on the annual occurrence and ecological characteristics of this species, it occurs various habitats only in the rainy season and adults only emerge in the morning. These individuals were only females. From the researches of this species at Tajimi-city, Gifu, Japan, both females and males of this species usually emerges at the soil of forest edges rather than inside forests. The areas of forest edges emerged males were limited depend on places. Males and females with intact wings, but only females come to houses or buildings. Small woodlands, gardens, and parks are the areas of origin in urban areas. We show that outbreaks of these insects leads are rarely nuisances because of the many fascinating characteristics of these pests.
A newly identified spliceosomal protein Ahed is essential for homeostasis of the epidermis
Authors: Sano Shigetoshi , Takaishi Mikiro , Ishimoto Tatsushi , Yagyu Ken-ichi , Kataoka Sayo , Kondo Motoki , Morisawa Keiko , Kinjo Sonoko , Ikeo Kazuho , Noma Shohei , Takahashi Chitose , Okazaki Yasushi , Tokunaga Masahiro , Kokubu Chikara , Takeda Junji 
Published: August 2023

Abstract

To identify genes that are essential for cellular and organ functions, we established a homozygous mutant mouse embryonic stem cell bank from which we identified a gene, namedAttenuated Hematopoietic Development (Ahed), that plays an essential role in hematopoiesis. Here we characterize the role ofAhedin skin development by analyzing mice with an epidermis-specific Ahed deficiency (EcKO). Those mice have increased numbers of apoptotic cells in the epidermis from the fetal stage. Thereafter, Ahed-EcKO mice develop skin barrier disruptions over time, which cause lethality soon after birth, showing epidermal abnormalities including the loss of filaggrin and an increase of pro-inflammatory gene expression. Experiments using Tam/ERT2-mediated inducibleAheddeletionin vivoandin vitrorevealed that anAheddeficiency leads to keratinocyte apoptosis, impairs keratinocyte proliferation and promotes dermatitis development. Since we found thatAhedhas a critical role in hematopoiesis as a spliceosomal protein that controls gene splicing of hematopoiesis-related molecules, we further characterized the protein interactions of Ahed with other spliceosomal proteins in HeLa cells, and identified the altered splicing of mRNAs inAhed-deficient keratinocytes. These results suggest thatAhedplays an indispensable role in processing mRNAs during development and in maintaining skin integrity, and more importantly, it contributes to mRNA splicing that is essential for multiple cell lineages.
LncRNA AL133415.1 promotes neuronal apoptosis and its association with Alzheimer's disease through the regulation of miR-125b/vimentin axis
Authors: Cheng Yi , Li Lihua , Zou Ting , Zhang Lei , Ma Long , zhou xiaohui 
Published: August 2023

Abstract
Background
Accumulating studies have identified that long noncoding RNA (lncRNA) are novel regulators in Alzheimer’s disease (AD). The goal of this study is to examine the impact of LncRNAAL133415.1 on cell viability, neuronal apoptosis, and oxidative stress and to further investigate the molecular mechanisms in AD.
Methods
In our study, we transfected control overexpression, lncRNA AL133415.1 overexpression, control siRNA, and lncRNA AL133415.1 siRNA into an SH-SY5Y-based AD cell model that was established using Aβ42 insult. We then measured cell viability and apoptosis using a CCK-8 assay and apoptosis marker expressions. Oxidative stress was assessed using a reactive oxygen species assay Kit and RT-qPCR was used to make observations. Total proteins were extracted and quantified using Western blot assays. We also determined the expression of Vimentin in each group.
Results
Transcriptome analysis revealed that vimentin (VIM) is a cis-target gene regulated by lncRNA AL133415.1. TargetScan database showed that VIM is a promising candidate target gene for miR-138-5p. In AD cell model, overexpression of lncRNA AL133415.1 inhibited cell viability and promoted cell apoptosis, while silencing lncRNA AL133415.1 had the opposite effect. Similarly, overexpression of lncRNA AL133415.1 inhibited Vimentin expression, while silencing lncRNA AL133415.1 promoted Vimentin expression. Overexpression of miR-138-5p also inhibited Vimentin expression, while inhibition of miR-138-5p expression promoted Vimentin expression. The levels of ROS were reduced in the lncRNA AL133415.1 silence group and increased in the lncRNA AL133415.1 overexpression group. Conversely, SOD levels were increased in the lncRNA AL133415.1 silence group and decreased in the lncRNA AL133415.1 overexpression group.
Conclusion
LncRNA AL133415.1 may interact with miR-138-5p to increase neuron cell death and reduce the expression of Vimentin in AD.
New PBI membranes doped with methylimidazolium triflate protic ionic liquid
Authors: Fadeeva Yuliya , Kuzmin Sergey , Shmukler Liudmila , Safonova Liubov 
Published: August 2023

Abstract
Due to the increasing global demand for sustainable energy sources, fuel cells are being considered as a green alternative to conventional power generation methods. Proton Exchange Membrane Fuel Cells (PEMFCs) are particularly promising energy sources due to their high energy efficiency and low environmental impact. However, there is an urgent need to develop proton-conducting materials that can operate under low-humidity conditions and at high working temperatures. In this study, new proton conducting membranes were prepared using poly-2,2'-(m-phenylene)-5,5'-bibenzimidazole (PBI) and varying amounts of a protic ionic liquid, methylimidazolium triflate [MeIm/TfO], through a solution casting method. The thermal properties and conductivity of these membranes were investigated. The obtained parameters indicate that PBI membranes doped with either MeIm/TfO or BuIm/TfO, which were previously studied by our group, are of definite interest for further investigation as potential electrolytes for PEMFCs.
Sequential signalling in equity crowdfunding: Testing crowd investors’ signal interpretation ability
Authors: Colombo Massimo G 
Published: August 2023

Abstract
In equity crowdfunding, it is unclear whether unsophisticated inexperienced crowd investors are capable of correctly interpreting ventures’ quality signals, even strong ones like affiliation with venture capital investors. Because of cognitive limitations, crowd investors may consider signals revealing platform’s private information on issuers’ quality to be more informative than ventures’ signals. Our findings based on 550 equity crowdfunding offerings in the U.S. show that the positive effect of affiliation with VCs on the success of equity crowdfunding campaigns is mediated by platforms’ choice of an equity compensation (i.e. their “skin in the game”) but only very partially. We deduce that crowd investors’ cognitive limitations may be less severe than one may believe.
JEL Classification: D26, G24, L26, M13
ALKBH5-mediated m 6 A modification of CDC6 mRNA impairs gastric cancer tumorigenesis and has prognostic significance
Authors: Liang Rui , Chen Xiaoyu , Yu Yi , Yang Yanling , Fan Huining , Chen Zhaoyu , Zhang Jing , Zhu Jinshui 
Published: August 2023

Abstract
Background: N6-methyladenosine (m6A) RNA methylation and its associated demethylase ALKBH5 participate in pathogenesis and progression of multiple malignancies. The present study aimed to reveal the biological function and clinical significance of ALKBH5 in gastric cancer (GC).
Method: The prognostic significance of ALKBH5 expression was assessed by using tissue microarray, immunohistochemical analyses and TCGA dataset in human GC. The functional role of ALKBH5 in GC tumorigenesis were explored in vitro and in vivo. Methylated RNA immunoprecipitation sequencing (MeRIP-seq), RNA-seq and MeRIP-PCR were utilized to identify the target genes of ALKBH5. RNA pull-down and RIP assays were conducted to validate the binding of CDC6 with ALKBH5 and YTHDF1.
Results: ALKBH5 was markedly downregulated in GC tissue samples and reduced expression of ALKBH5 correlated with poor prognosis. Multivariate Cox regression analysis unveiled that ALKBH5 expression was an independent prognostic factor for overall survival in human patients with GC. Furthermore, ALKBH5 overexpression suppressed GC cell proliferation and cycle progression in vitro and in vivo, whereas knockdown of ALKBH5 harbored the opposite effects. Mechanistically, ALKBH5 abolished m6A modification of CDC6 mRNA, and the m6A reader YTHDF1 could directly recognize and bind to the m6A site on CDC6 mRNA. CDC6 acted as an oncogenic factor and had poor prognosis in GC.
Conclusions: Our findings demonstrate that ALKBH5-mediated m6A modification of CDC6 mRNA impairs GC tumorigenesis and has prognostic significance in patients with GC.
Enhancement of lubricant replenishment under limited lubricant supply in rolling bearings
Authors: Liu Chenglong , Guo Feng , Li Xinming , Wong Patrick , Poll Gerhard , Liu Muyuan 
Published: August 2023

Abstract
This paper proposes a stripe-shaped surface pattern, aiming to enhance oil replenishment in rolling bearings that operate in challenging conditions where starved lubrication can result in failure. The pattern can be created through a chemical coating and applied to both sides of the bearing raceway, transforming it into a replenishment-augmented rolling element bearing (RaREB) that exhibits reduced friction. RaREB bearings facilitate better distribution and replenishment of lubricant in the bearing raceway, leading to enhanced anti-friction and extended service life, particularly in situations with limited lubricant supply. Test results confirmed the effectiveness of RaREB bearings in maintaining the desired thickness of the lubricating film and reducing friction torque. Additionally, a droplet transport simulation model was utilized to demonstrate the effect of the stepped wettability on oil replenishment. The proposed design holds practical significance for enhancing bearing performance in extreme operating conditions.
Barriers in Management of Malnutrition During COVID-19: Among Children Aged 6 to 71 Months in Buldhana District of Maharashtra in India
Authors: Ingle Sagar Dhirasrao , Nagdeve Dewaram 
Published: August 2023

Abstract
Background The management of moderate acute malnutrition (MAM) in children is crucial to prevent the progression to severe acute malnutrition (SAM). This study aimed to identify the barriers to managing MAM in children aged 6 to 71 months in the Buldhana district of Maharashtra, India.Method The research followed a descriptive phenomenological design and involved six focus group discussions with mothers or caregivers of children aged 6 to 71 months, along with 20 in-depth interviews with nutrition rehabilitation services provider.Result Several themes emerged from the analysis, causes of child malnutrition such as a low child-caring time for the mother, lack of awareness, cultural beliefs, and poor maternal health. Difficulties were faced during identification, such as multiple rounds of child screening, inadequate treatment during screening, nutrition counselling issues, reduced follow-up visits, and effectiveness of services. Maternal-level barriers encompassed food insecurity, lack of food choice, mismanagement of self-grown food grains, and cultural barriers. The study also identified barriers and suggestions to improve the service, including feelings of shame associated with having children with malnutrition and obstacles in managing MAM. The COVID-19 pandemic had a severe impact on malnutrition management. Providing nutrition counselling to mothers of children with MAM without food supplementation increased the risk of negative outcomes for these children.Conclusion The study revealed that both maternal-level and service provider-level barriers negatively affect the management of malnutrition in study area. The government should prioritize and facilitate the integration of supplementary food into existing MAM management practices.
Direct Salinity Effect on Absorbance and Flourescence of Chernozem Water-Extractable Organic Matter
Authors: Kholodov Vladimir A. , Danchenko Natalia N. , Ziganshina Aliya R. , Yaroslavtseva Nadezhda V. , Semiletov Igor P. 
Published: August 2023

Abstract
Soil-derived dissolved organic matter (DOM) has a significant impact on aquatic ecosystems. Identifying the fluorescence signatures of DOM from different soils in river and sea waters can provide valuable insights into its migration patterns. This makes crucial the assessment of pH, salinity, and other parameters contribution to the variability of DOM fluorescence. Present study investigates the changes of DOM of typical Chernozems under varying salinity using UV-visible absorbance and excitation–emission matrices of fluorescence spectroscopy coupled with parallel factor analysis (EEMs-PARAFAC). Water-extractable organic matter (WEOM) as a proxy for DOM was isolated from soils of two field experiment plots with contrasting land uses: long-term bare fallow (LTBF) and annually mowed steppe (Steppe). The extracts were incubated in the dark with varying NaCl concentrations and examined. Steppe WEOM exhibited high structural and aggregation resistance to salinity changes, while significant changes in optical parameters and loads of PARAFAC components were observed for LTBF WEOM. The remarkable stability of the Steppe WEOM can be attributed to its chemical diversity. Two distinct and sufficiently stable humic-like PARAFAC components have the potential to serve as markers of Chernozem DOM. The findings contribute to the limited existing knowledge on the direct influence of salinity on the transformation of specific soil types DOM.
Fracture phases of the CT specimens printed in PLA according to the raster width
Authors: Aourik Oumaima , Chouaf Abdelkerim , Othmani Mourad 
Published: August 2023

Abstract

This article investigates the impact of raster width on crack propagation resistance in structures manufactured using the FDM (Fused Deposition Modeling) additive manufacturing process. This process involves a large number of variables to be controlled, which influence the mechanical properties and quality of the parts produced. During layer-by-layer printing, the filaments making up each layer fuse together on adjacent and overlapping sides. This fusion occurs at the contact surfaces, which depend mainly on the raster's width and the deposited filaments' length. The quality of this fusion plays a crucial role in the resistance to crack propagation, both between filaments and between layers. Therefore, this article aims to examine how raster width affects resistance to crack propagation in FDM structures. In this study, we developed two approaches; one is experimental based on CT (Compact Tension) specimens to assess the fracture toughness of poly-lactic acid (PLA)-based polymers using the theoretical approach of the J integral. To do so, we determined the strength curves (J-∆a) and deduced the JICparameter for different raster widths (l = 0.42 mm, l = 0.56 mm and l = 0.68 mm). To better understand the behavior of contact zones between filaments during fracture, we developed a simplified numerical approach. The numerical results obtained were analyzed and discussed on the basis of observations of the fracture facies of CT specimens.
Validation of reliability, repeatability and consistency of Three-dimensional Choroidal Vascular Index
Authors: Ma Feiyan , Bai Yifan , Duan Jialiang , Liang Yuchen , Shang Qingli 
Published: August 2023

Abstract
PURPOSE
To investigate the reliability, repeatability and consistency of choroidal vascularity index (CVI) measurements provided by an artificial intelligence-based software in normal subjects.
METHODS
One hundred and twenty-five eyes of 125 healthy volunteers were included in this prospective study. The repeatability of the measurements was analyzed based on the in-built ETDRS segmentation with 3D-CVI was obtained automatically on the segmented diagram (CVI1). Ten eyes from this population were selected to study agreement between CVIs obtained from SS-OCT and that from SD-OCT (CVI2) based on the 6*6mm square overlayed over the fundus image analyzed by intraclass correlation coefficient. The influencing factors including age, gender, partition, axial length and spherical equivalent on CVI was further investigated.
RESULTS
Intraclass correlation coefficient between different measurements was 0.934 (95% CI: 0.812–0.956). Intraclass correlation coefficient between centered and CVI1 and CVI2 was 0.887 (95% CI: 0.796–0.938, P value < 0.001). The mean difference between CVI1 and CVI2 was 0.063 ± 0.017. CVI measured with SS-OCTA showed stronger correlations with axial length and age but not correlated with gender.
CONCLUSION
There is good agreement between CVIs obtained from the built-in software that requires less timing in manual quantification. Studies investigating choroidal vascularity can be standardized by the AI-based CVI analyze software.
Physical activity interventions to reduce fear of falling in older adults with frailty: a systematic review of randomized controlled trials
Authors: Savvakis Ioannis , Adamakidou Theodoula , Kleisiaris Christos 
Published: August 2023

Abstract
Background
Frailty in older adults leads to progressive deterioration of their physical condition and makes them prone to develop Fear of Falling (FoF). Physical activity interventions appear to be effective in managing the components of frailty but there is no clear evidence to determine whether physical activity may affect FoF in frail and pre-frail older adults.
Objective
Τhis systematic literature review aims to synthesize evidence on the relationship between the physical interventions to ameliorate balance, strength, and mobility and FοF reduction in older adults with frailty.
Design
Studies assessing physical activity interventions for frail and pre-frail older adults aged 60 years and older were identified in English through searches in PubMed, ScienceDirect, and Cochrane Central Register of Controlled Trials databases till February 2023. Study quality was assessed and a qualitative synthesis of results was performed.
Results
A total of 13 studies published were included. All of them were Randomized Control Trials and the most frequent assessment tool used to assess FoF (10 of 13 studies) was the Fall Efficacy Scale – International (FES-I). Six studies were assessed as having a low risk of bias. Cumulatively, the findings of this review indicate that physical activity interventions are effective in reducing the FoF of older adults with frailty.
Conclusion
The results are encouraging and recapitulate the positive role of physical interventions in FoF reduction. However, future research would benefit from longer follow-up periods, longer intervention duration, and participation of interdisciplinary teams.
Comparison of surgical outcomes following femtosecond laser-assisted LASIK (Femto-LASIK) versus small incision lenticule extraction (SMIL) for myopia and astigmatism
Authors: Mohammed MS.c Marrwan Hisham , Halboos Mustafa Tawfeeq , Al-Jenabi Ziyad Kamel , M.Sc. Noor Khamees Hamad 
Published: August 2023

Abstract
Purpose
To compare the visual, refractive, and topographic outcomes of patients who underwent Femto-LASIK and SMILE.
Methods
This historical cohort study selected 83 eyes of 83 patients with myopic and myopic astigmatism. Patients were divided into two groups based on the surgical procedure: femto-LASIK-treated (46 patients) and SMILE-treated patients (37 eyes). In all patients, corrected distance visual acuity (CDVA), uncorrected distance visual acuity (UDVA), spherical component, spherical equivalent (SE), cylindrical component, and some tomography readings were measured preoperatively and compared with the outcomes 45 days after surgery. In addition, the symptoms reported by patients were investigated in follow-ups on the 10th, 30th, and 45th days following the operation.
Results
Significantly better spherical refractive outcomes were associated with SMILE than Femto-LASIK at 45 days postoperatively (sphere component: -0.22 ± 0.61 D for Femto-LASIK and − 0.04 ± 0.17 D for SMILE, and P = 0.080; SE: -0.37 ± 0.72 D for Femto-LASIK and − 0.09 ± 0.21 D for SMILE, and P = 0.021). In addition, the SMILE procedure induced more flattening effect on steep-K readings than Femto-LASIK 45 days after the surgery (41.96 ± 2.23 D for SMILE and 40.65 ± 2.04 D for Femto-LASIK, and P = 0.007). No significant differences were found between the two study groups' postoperative measurements of flat-K and K-max. In addition, the higher proportions of patients who were treated with SMILE complained of severe dryness sensation at ten days postoperatively, no patient complained of this symptom at 45 days following both procedures.
Conclusions
By the end of the 45-day follow-up after the operation, SMILE would be a slightly better surgical procedure providing less postoperative myopic refraction and fewer symptoms.
Categorization of Text using Long Short-Term Memory with Glove
Authors: Sirohi Neeraj Kumar , Bansal Mamta 
Published: August 2023

Abstract
Text files from the web, articles from magazines, and medical research can all be organized, arranged, and categorized using text classifiers. For illustration, categories like entertainment, business, sports, science, and technology might be used to categorize new content; When classifying text, important feature selection and data sparsity problems repeatedly arise in standard techniques. Text classification using conventional machine learning techniques is highly effective and has qualities of stability. Regarding large-scale dataset training, it does have some drawbacks. In this instance, grouping news articles into some labels in the dataset requires the use of a multi-label text grouping method. A potential approach to fixing issues with text categorization systems is deep learning. The LSTM was utilized in this research to utilize one method using recurrent neural networks for deep learning. The technique described in this article utilizes 300-dimensional word embeddings generated by Global Vectors (GloVe). The parameters were carefully selected to demonstrate the effectiveness of utilizing LSTM with GloVe features in text categorization. A comprehensive tuning process was carried out, assessing the performance of the four suggested LSTM models by evaluating them against a sizable corpus for comparative analysis. According to the results, the third model's accuracy for text categorization using LSTM and GloVe is 96.36, while The average F1-score, precision, and recall are 96. Furthermore, Utilising the GloVe feature, LSTM typically generates visual outcomes that are nearly well-fit.