bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resolving the flavor structure in the MFV-SMEFT
Authors: Bruggisser Sebastian , van Dyk Danny , Westhoff Susanne 
Published: February 2023

Abstract
We constrain the flavor structure of Wilson coefficients in the Standard Model Effective Field Theory (SMEFT) from data. In the SMEFT, new physics effects in couplings of up-type and down-type quarks are related through the Cabibbo-Kobayashi-Maskawa mixing matrix. We exploit this relation to pin down potential new sources of flavor symmetry breaking in a global analysis of high- and low-energy data from the LHC, LEP, and b factory experiments. We demonstrate the power of such an analysis by performing a combined fit of effective four-quark and two-quark couplings contributing to a large set of flavor, top-quark, electroweak, and dijet observables. All four sectors are needed to fully resolve the flavor structure of left-chiral four-quark couplings without leaving blind directions in the parameter space. Although we work in the framework of minimal flavor violation, our strategy applies as well to other flavor patterns, like U(2) flavor symmetry or leptoquark scenarios.
Anomalous Energy Flux in Critical $$L^p$$-Based Spaces
Authors: Burczak Jan , Sattig Gabriel 
Published: February 2023

AbstractWe construct a three-dimensional vector field that exhibits positive energy flux at every Littlewood–Paley shell and has the best possible regularity in $$L^p$$

L
p

-based spaces, $$p \le 3$$

p
≤
3

; in particular, it belongs to $$H^{(\frac{5}{6})^-}$$

H

(

5
6

)

-

.
ALMOST CYCLIC REGULAR SEMISIMPLE ELEMENTS IN IRREDUCIBLE REPRESENTATIONS OF SIMPLE ALGEBRAIC GROUPS
Authors: TESTERMAN D. M. , ZALESSKI ALEXANDRE E. 
Published: February 2023

AbstractLet G be a simple linear algebraic group defined over an algebraically closed field of characteristic p ≥ 0 and let ϕ be a nontrivial p-restricted irreducible representation of G. Let T be a maximal torus of G and s ϵ T. We say that s is Ad-regular if α(s) ≠ β(s) for all distinct T-roots α and β of G. Our main result states that if all but one of the eigenvalues of ϕ(s) are of multiplicity 1 then, with a few specified exceptions, s is Ad-regular. This can be viewed as an extension of our earlier work, in which we show that, under the same hypotheses, either s is regular or G is a classical group and ϕ is “essentially” (a twist of) the natural representation of G.
Klimawandel und psychische Gesundheit. Positionspapier einer Task-Force der DGPPN
Authors: Heinz Andreas , Meyer-Lindenberg Andreas ,   DGPPN-Task-Force „Klima und Psyche“, Heinz Andreas , Meyer-Lindenberg Andreas , Adli Mazda , Bornheimer Barbara , Brandt Lasse , Hurlemann René , Karl Sebastian , Knoblauch Hans , Marsh Nina , Nikendei Christoph , Pistol Sandy , Riedel-Heller Steffi , Schomburg Anna-Karina , Shukla Kirsten , Weinmann Stefan , Welzel Franziska , Gerlinger Gabriel , Holzhausen Julie , John Katja , Lork Isabelle , Sander Julia , Walinski Annika 
Published: February 2023

ZusammenfassungDer Klimawandel und die damit häufiger auftretenden Extremwetterereignisse wirken sich direkt negativ auf die psychische Gesundheit aus. Naturkatastrophen gehen insbesondere mit einem Anstieg von Depressionen, Angst- und Traumafolgestörungen einher. Indirekte Folgen des Klimawandels wie Nahrungsmittelknappheit, ökonomische Krisen, gewaltvolle Konflikte und unfreiwillige Migration stellen zusätzlich massive psychische Risiko- und Belastungsfaktoren dar. Klimaangst und Solastalgie, die Trauer um verlorenen Lebensraum, sind neue psychische Syndrome angesichts der existenziellen Bedrohung durch die Klimakrise. Eine nachhaltige Psychiatrie muss sich dementsprechend auf steigenden und veränderten Bedarf einstellen. Psychiatrische Behandlungsprinzipien müssen die Prävention stärker in den Blick nehmen, um das Versorgungssystem insgesamt zu entlasten. Ressourcenverschwendung und CO2-Ausstoß im psychiatrischen Behandlungsablauf sowie Infrastruktur müssen wahrgenommen und verhindert werden. Psychiatrische Aus‑, Fort- und Weiterbildungskonzepte sollen um die Thematik des Klimawandels erweitert werden, um Fachkräfte, Betroffene und Öffentlichkeit umfassend zu informieren, zu sensibilisieren und zu klimafreundlichem und gesundheitsförderlichem Verhalten anzuregen. Die Auswirkungen des Klimawandels auf die psychische Gesundheit müssen tiefergehend erforscht werden. Die DGPPN wird Förderer und strebt die Klimaneutralität bis 2030 an. Sie hat sich zu klimaschonenden und energiesparenden Maßnahmen im Bereich der Finanzwirtschaft, in Bezug auf den DGPPN-Kongress sowie die DGPPN-Geschäftsstelle verpflichtet.
Standardized multi-planar reformation improves the reliability of the assessment of the anterolateral ligament in ACL-deficient knees
Authors: Hess Silvan , Hecker Andreas , Egli Rainer J. , Eberlein Sophie C. , Klenke Frank M. 
Published: February 2023

Abstract
Purpose
The anterolateral ligament (ALL) is an important structure for controlling anterolateral rotatory stability of the knee. Its assessment, however, is difficult using standardized MRI images. The goal of this study was to assess the reliability of judging the integrity of the ALL on multi-planar reformatted (MPR) MRI images and on standard coronal reformatted (SCR) MRI images in knees with an anterior cruciate ligament (ACL) rupture.

Methods
Forty-eight patients (14 females, 34 males, 30 ± 6 years (mean age ± standard deviation)) with acute ACL ruptures (< 2 weeks) and no additional knee injuries (except segond fractures) were included. Images were assessed by two independent raters twice with at least a 2-week interval in between. The assessment was first performed on SCR images and thereafter on MPR images. Images were judged for assessability of the ALL and then the integrity of the ALL was rated.

Results
Depending on rater and read, the ALL was judged as “torn” in between 5 (10.4%) and 11 (22.9%) patients out of 48 patients on SCR images. On MRP images, the ALL was judged as “torn” in between 5 (10.4%) and 6 (12.5%) patients out of 48 patients, depending on rater and read. Inter- and intra-rater reliability for the assessment of the ALL using MPR images was “substantial” to “almost perfect”. Inter- and intra-rater reliability for the assessment using SCR was “fair” to “substantial”.

Conclusion
MPR images should be used when assessing the integrity of the ALL. Assessment quality is independent of patient positioning during MRI acquisition and the ALL can be displayed in full length on one image.

Level of evidence
Level III
A shallow morphology of the intertubercular groove is associated with medial and bilateral but not lateral pulley lesions
Authors: Kleim Benjamin Daniel , Carbonel Jose Fernando Sanchez , Hinz Maximilian , Rupp Marco-Christopher , Scheiderer Bastian , Imhoff Andreas Balthasar , Siebenlist Sebastian 
Published: February 2023

Abstract
Purpose
To investigate the influence of intertubercular groove (IG) morphology on the development of different types of biceps reflection pulley (BRP) injuries.

Methods
A consecutive cohort of 221 patients with ventral shoulder pain and a preoperative diagnosis suspecting BRP injury, who underwent arthroscopy, was retrospectively reviewed. The presence or absence as well as type of pulley injury (medial, lateral or bilateral) was confirmed arthroscopically. The intertubercular groove was evaluated on MRIs after triplanar reconstruction of the axial plane. IG depth, width, medial wall angle (MWA), lateral wall angle (LWA) and total opening angle (TOA) were measured. IG depth and width were expressed in relation to the humeral head diameter. Measurements were performed by two clinicians independently and averaged.

Results
Of 166 included patients 43 had bilateral, 65 medial and 38 lateral BRP lesions. 20 patients had intact BRPs and represented the control group.
The intra-class correlation coefficient of measurements was 0.843–0.955. Patients with a medial or bilateral BRP injury had a flatter MWA (38.8° or 40.0° vs. 47.9°, p < 0.001), wider TOA (96.1° or 96.6° vs. 82.6°, p < 0.001), greater width (12.5 or 12.3 vs. 10.8 mm, p = 0.013) and shallower depth (5.5 or 5.4 vs. 6.2 mm, p < 0.001) than the control group. Conversely, the IG morphology of those with lateral BRP injuries did not differ significantly from the control group. The odds ratio for a medial or bilateral BRP injury when the TOA exceeded 95° was 6.8 (95% confidence interval 3.04–15.2).

Conclusion
A dysplastic type of IG morphology with a wide TOA, flat MWA, decreased depth and increased width is associated with the presence of medial and bilateral BRP injuries. A TOA of > 95° increases the likelihood of a medial or bilateral BRP injury 6.8-fold. Lateral BRP injuries are not associated with dysplastic IG morphology. Concomitant LHBT surgery may, therefore, not always be necessary during isolated supraspinatus tendon repair.

Level of evidence
Level III.
Assessment of the compressive mechanical behavior of injection molded E-glass/polypropylene by mechanical testing and X-ray computed tomography
Authors: Stamopoulos Antonios G. , Gazza Francesco , Neirotti Giuseppe 
Published: February 2023

AbstractNowadays, thermoplastic composite materials are considered among the most promising ones as they are gaining the interest of many industrial sectors due to their eco-friendly features such as their recyclability and their low-cost demand while being produced in high volumes. Among the most concerning issues regarding the injection molded, short fiber-reinforced composites are the fiber distribution, the fiber orientation, and their effect on the overall mechanical performance. In the present work, the effect of the injection molding on the compressive properties is investigated experimentally. In this context, compressive mechanical tests have been conducted in a range between subzero and elevated temperatures using specimens oriented parallel and perpendicular to the injection direction. In addition, X-ray computed tomography is implemented for characterizing some crucial features such as the fiber volume fraction, in local and global scale, and the orientation of the fibers through the thickness and length of the material. The results revealed a different compressive mechanical behavior between the two specimen categories in all the testing temperatures. In addition, the results obtained by the nondestructive testing revealed a significant variation of the fiber content locally and a notable difference between distinct zones through the thickness.
Monetary policy, funding cost and banks’ risk-taking: evidence from the USA
Authors: Bürgi Constantin , Jiang Bo 
Published: February 2023

AbstractHow much deposits and equity a bank has influences how a banks’ lending responds to monetary policy. While the responsiveness for the bank lending channel has been well established, this is not the case for the risk-taking channel (RTC). We show in a value-at-risk RTC model that the lending for banks with relatively more equity and non-interest-bearing deposits should respond less to monetary policy tightening. This suggests that non-interest-bearing deposits act as “pseudo capital.” In a panel of US banks, we find strong evidence in support of our model for various risk measures.
Evaluation of gravitational curvatures for a tesseroid and spherical shell with arbitrary-order polynomial density
Authors: Deng Xiao-Le 
Published: February 2023

AbstractIn recent years, there are research trends from constant to variable density and low-order to high-order gravitational potential gradients in gravity field modeling. Under the research circumstances, this paper focuses on the variable density model for gravitational curvatures (or gravity curvatures, third-order derivatives of gravitational potential) of a tesseroid and spherical shell in the spatial domain of gravity field modeling. In this contribution, the general formula of the gravitational curvatures of a tesseroid with arbitrary-order polynomial density is derived. The general expressions for gravitational effects up to the gravitational curvatures of a spherical shell with arbitrary-order polynomial density are derived when the computation point is located above, inside, and below the spherical shell. When the computation point is located above the spherical shell, the general expressions for the mass of a spherical shell and the relation between the radial gravitational effects up to arbitrary-order and the mass of a spherical shell with arbitrary-order polynomial density are derived. The influence of the computation point’s height and latitude on gravitational curvatures with the polynomial density up to fourth-order is numerically investigated using tesseroids to discretize a spherical shell. Numerical results reveal that the near-zone problem exists for the fourth-order polynomial density of the gravitational curvatures, i.e., relative errors in $$\log _{10}$$

log
10

scale of gravitational curvatures are large than 0 below the height of about 50 km by a grid size of $$15'\times 15'$$

15
′

×

15
′

. The polar-singularity problem does not occur for the gravitational curvatures with polynomial density up to fourth-order because of the Cartesian integral kernels of the tesseroid. The density variation can be revealed in the absolute errors as the superposition effects of Laplace parameters of gravitational curvatures other than the relative errors. The derived expressions are examples of the high-order gravitational potential gradients of the mass body with variable density in the spatial domain, which will provide the theoretical basis for future applications of gravity field modeling in geodesy and geophysics.
Early effects of lurasidone treatment in a chronic mild stress model in male rats
Authors: Creutzberg Kerstin Camile , Begni Veronica , Marchisella Francesca , Papp Mariusz , Riva Marco Andrea 
Published: February 2023

Abstract
Rationale
Stress represents a major contributor to the development of mental illness. Accordingly, exposure of adult rats to chronic stress represents a valuable tool to investigate the ability of a pharmacological intervention to counteract the adverse effects produced by stress exposure.

Objectives
The aim of this study was to perform a time course analysis of the treatment with the antipsychotic drug lurasidone in normalizing the anhedonic phenotype in the chronic mild stress (CMS) model in order to identify early mechanisms that may contribute to its therapeutic activity.

Methods
Male Wistar rats were exposed to CMS or left undisturbed for 7 weeks. After two weeks of stress, both controls and CMS rats were randomly divided into two subgroups that received vehicle or lurasidone for five weeks. Weekly measures of sucrose intake were recorded to evaluate anhedonic behavior, and animals were sacrificed at different weeks of treatment for molecular analyses.

Results
We found that CMS-induced anhedonia was progressively improved by lurasidone treatment. Interestingly, after two weeks of lurasidone treatment, 50% of the animals showed a full recovery of the phenotype, which was associated with increased activation of the prefrontal and recruitment of parvalbumin-positive cells that may lead to a restoration of excitatory/inhibitory balance.

Conclusion
These results suggest that the capacity of lurasidone to normalize anhedonia at an early stage of treatment may depend on its ability to modulate the function of the prefrontal cortex.
Carbon dots as a versatile tool to monitor insulin aggregation
Authors: Zingale Gabriele Antonio , Distefano Alessia , Pandino Irene , Tuccitto Nunzio , Oliveri Valentina , Gaeta Massimiliano , D’Urso Alessandro , Arcoria Alfio , Grasso Giuseppe 
Published: February 2023

AbstractThe possibility to monitor peptide and protein aggregation is of paramount importance in the so-called conformational diseases, as the understanding of many physiological pathways, as well as pathological processes involved in the development of such diseases, depends very much on the actual possibility to monitor biomolecule oligomeric distribution and aggregation. In this work, we report a novel experimental method to monitor protein aggregation, based on the change of the fluorescent properties of carbon dots upon protein binding. The results obtained in the case of insulin with this newly proposed experimental approach are compared with those obtained with other common experimental techniques normally used for the same purpose (circular dichroism, DLS, PICUP and ThT fluorescence). The greatest advantage of the hereby presented methodology over all the other experimental methods considered is the possibility to monitor the initial stages of insulin aggregation under the different experimental conditions sampled and the absence of possible disturbances and/or molecular probes during the aggregation process.
Graphical abstract
Liquid chromatography and differential mobility spectrometry—data-independent mass spectrometry for comprehensive multidimensional separations in metabolomics
Authors: Ekmekciu Lysi , Hopfgartner Gérard 
Published: February 2023

AbstractThe benefits of combining drift time ion mobility (DTIMS) with liquid chromatography–high-resolution mass spectrometry (HRMS) have been reported for metabolomics but the use of differential time mobility spectrometry (DMS) is less obvious due to the need for rapid scanning of the DMS cell. Drift DTIMS provides additional precursor ion selectivity and collisional cross-section information but the separation resolution between analytes remains cell- and component-dependent. With DMS, the addition of 2-propanol modifier can improve the selectivity but on cost of analyte MS response. In the present work, we investigate the liquid chromatography–mass spectrometry (LC–MS) analysis of a mix of 50 analytes, representative for urine and plasma metabolites, using scanning DMS with the single modifiers cyclohexane (Ch), toluene (Tol), acetonitrile (ACN), ethanol (EtOH), and 2-propanol (IPA), and a binary modifier mixture (cyclohexane/2-propanol) with emphasis on selectivity and signal sensitivity. 1.5% IPA in the N2 stream was found to suppress the signal of 50% of the analytes which could be partially recovered with the use of IPA to 0.05% as a Ch/IPA mixture. The potential to use the separation voltage/compensation voltage/modifier (SV/CoV/Mod) feature as an additional analyte identifier for qualitative analysis is also presented and applied to a data-independent LCxDMS-SWATH-MS workflow for the analysis of endogenous metabolites and drugs of abuse in human urine samples from traffic control.
Graphical Abstract
Validation of simplified uptake measures against dynamic Patlak Ki for quantification of lesional 89Zr-Immuno-PET antibody uptake
Authors: Wijngaarden Jessica E. , Huisman Marc C. , Jauw Yvonne W. S. , van Dongen Guus A. M. S. , Greuter Henri N. J. M. , Schuit Robert C. , Cleveland Matthew , Gootjes Elske C. , Vugts Daniëlle J. , Menke-van der Houven van Oordt C. Willemien , Boellaard Ronald 
Published: February 2023

Abstract

Purpose

Positron emission tomography imaging of zirconium-89-labelled monoclonal antibodies (89Zr-Immuno-PET) allows for visualisation and quantification of antibody uptake in tumours in vivo. Patlak linearization provides distribution volume (VT) and nett influx rate (Ki) values, representing reversible and irreversible uptake, respectively. Standardised uptake value (SUV) and tumour-to-plasma/tumour-to-blood ratio (TPR/TBR) are often used, but their validity depends on the comparability of plasma kinetics and clearances. This study assesses the validity of SUV, TPR and TBR against Patlak Ki for quantifying irreversible 89Zr-Immuno-PET uptake in tumours.

Methods
Ten patients received 37 MBq 10 mg 89Zr-anti-EGFR with 500 mg/m2 unlabelled mAbs. Five patients received two doses of 37 MBq 89Zr-anti-HER3: 8–24 mg for the first administration and 24 mg–30 mg/kg for the second. Seven tumours from four patients showed 89Zr-anti-EGFR uptake, and 18 tumours from five patients showed 89Zr-anti-HER3 uptake. SUVpeak, TPRpeak and TBRpeak values were obtained from one to six days p.i. Patlak linearization was applied to tumour time activity curves and plasma samples to obtain Ki.

Results
For 89Zr-anti-EGFR, there was a small variability along the linear regression line between SUV (− 0.51–0.57), TPR (− 0.06‒0.11) and TBR (− 0.13‒0.16) on day 6 versus Ki. Similar doses of 89Zr-anti-HER3 showed similar variability for SUV (− 1.3‒1.0), TPR (− 1.1‒0.53) and TBR (− 1.5‒0.72) on day 5 versus Ki. However, for the second administration of 89Zr-anti-HER3 with a large variability in administered mass doses, SUV showed a larger variability (− 1.4‒2.3) along the regression line with Ki, which improved when using TPR (− 0.38–0.32) or TBR (− 0.56‒0.46).

Conclusion
SUV, TPR and TBR at late time points were valid for quantifying irreversible lesional 89Zr-Immuno-PET uptake when constant mass doses were administered. However, for variable mass doses, only TPR and TBR provided reliable values for irreversible uptake, but not SUV, because SUV does not take patient and mass dose-specific plasma clearance into account.
Associations between KIR/KIR-ligand genotypes and clinical outcome for patients with advanced solid tumors receiving BEMPEG plus nivolumab combination therapy in the PIVOT-02 trial
Authors: Feils A. S. , Erbe A. K. , Birstler J. , Kim K. , Hoch U. , Currie S. L. , Nguyen T. , Yu D. , Siefker-Radtke A. O. , Tannir N. , Tolaney S. M. , Diab A. , Sondel P. M. 
Published: February 2023

AbstractBempegaldesleukin (BEMPEG), a CD122-preferential IL2 pathway agonist, has been shown to induce proliferation and activation of NK cells. NK activation is dependent on the balance of inhibitory and excitatory signals transmitted by NK receptors, including Fc-gamma receptors (FCγRs) and killer immunoglobulin-like receptors (KIRs) along with their KIR-ligands. The repertoire of KIRs/KIR-ligands an individual inherits and the single-nucleotide polymorphisms (SNPs) of FCγRs can influence NK function and affect responses to immunotherapies. In this retrospective analysis of the single-arm PIVOT-02 trial, 200 patients with advanced solid tumors were genotyped for KIR/KIR-ligand gene status and FCγR SNP status and evaluated for associations with clinical outcome. Patients with inhibitory KIR2DL2 and its ligand (HLA-C1) observed significantly greater tumor shrinkage (TS, median change −13.0 vs. 0%) and increased PFS (5.5 vs. 3.3 months) and a trend toward improved OR (31.2 vs. 19.5%) compared to patients with the complementary genotype. Furthermore, patients with KIR2DL2 and its ligand together with inhibitory KIR3DL1 and its ligand (HLA-Bw4) had improved OR (36.5 vs. 19.6%), greater TS (median change −16.1 vs. 0%), and a trend toward prolonged PFS (8.4 vs. 3.6 months) as compared to patients with the complementary genotype. FCγR polymorphisms did not influence OR/PFS/TS.These data show that clinical response to BEMPEG plus nivolumab treatment in the PIVOT-02 trial may be associated with the repertoire of KIR/KIR-ligands an individual inherits. Further investigation and validation of these results may enable KIR/KIR-ligand genotyping to be utilized prospectively for identifying patients likely to benefit from certain cancer immunotherapy regimens.