bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estado nutricional e fatores associados à prevalência de obesidade entre escolares das redes pública e privada de ensino fundamental de Maceió, Alagoas
Authors: Da Silva Ferreira Haroldo , Coelho Vieira da Silva Bárbara , Lopes de Assunção Monica 
Published: August 2023

Objetivou-se classificar o estado nutricional e investigar os fatores associados à prevalência de obesidade entre escolares do ensino fundamental público e privado de Maceió. Trata-se de um estudo transversal com amostra probabilística de 1.510 alunos (9,8±0,5 anos) de escolas públicas (n=931) e privadas (n=579). Obtiveram-se dados socioeconômicos, demográficos, antropométricos e dietéticos. O estado nutricional foi estabelecido por antropometria segundo os critérios da OMS. A obesidade foi definida por IMC-para-idade >2 z. A medida de associação foi a razão de prevalência (RP) e respectivo IC95%, calculados por regressão de Poisson. Apenas 1,2% dos investigados apresentaram déficit estatural. A prevalência de obesidade foi maior entre os alunos da rede privada (22,1% vs. 10,3%; RP=2,14; IC95%=1,66-2,76). Na análise bruta associaram-se à obesidade: menor número de moradores no domicílio; comprar lanche na cantina da escola; não ser usuário de programas assistenciais do governo; maior consumo de alimentos não saudáveis; e pertencer à escola privada. Na análise ajustada, apenas esta última variável manteve-se associada (p<0,05), possivelmente, pelo fato de a maioria dos demais preditores ocorrer com maior frequência no âmbito dos estabelecimentos particulares. A obesidade é o principal agravo nutricional encontrado entre os alunos do ensino fundamental de Maceió, condição que se associa, de forma independente, ao fato de pertencer à escola privada.
Pengaruh Ekstrak Etanolik Daun Kelor (Moringa oleifera, Lam.) Terhadap Ekspresi Reseptor ACE2 Pankreas Tikus Wistar (Rattus Norvegicus) Model Sindrom Metabolik
Authors: Julian Lydia , Budiani Dyah Ratna , Jarot Subandono  
Published: August 2023

Pendahuluan: Angiotensin Converting Enzyme 2 merupakan enzim yang berada pada membran sel beberapa organ, salah satunya pankreas. ACE2 memiliki fungsi untuk mengkatalis perubahan angiotensin II menjadi angiotensin 1-7. Pada penderita sindrom metabolik terjadi hiperglikemia, hiperinsulinemia, obesitas, serta resistensi insulin yang meningkatkan produksi angiotensin II dan aktivitas sistem RAS. Ekspresi ACE2 meningkat sebagai kompensasi dari peningkatan sistem RAS. Daun kelor memiliki mampu mengatasi sindrom metabolik. Penelitian bertujuan untuk melihat pengaruh ekstrak etanolik daun kelor terhadap ekspresi reseptor ACE2 pankreas tikus wistar terinduksi sindrom metabolik.

Metode: Penelitian bersifat eksperimental laboratorik dengan post-test only control group design. Sampel berupa 30 tikus dibagi kedalam 5 kelompok, KI sebagai kelompok kontrol; KII sebagai kelompok model SM diinduksi STZ-NA serta pakan tinggi lemak; KIII, KIV, dan KV sebagai kelompok model SM diinduksi STZ-NA, pakan tinggi lemak, dengan perlakuan asupan ekstrak etanolik daun kelor selama 28 hari dengan dosis 150 mg/kgBB, 250 mg/kgBB, dan 350 mg/kgBB. Ekspresi reseptor ACE2 dihitung menggunakan rumus Intensity Distribution Score. Analisis menggunakan uji one-way ANOVA dan uji post-hoc Tukey HSD.

Hasil: Ekspresi reseptor ACE2 tertinggi pada KII (222.56) dan terendah pada KV (188.38). Uji statistik didapatkan ekspresi reseptor ACE2 signifikan (p<0.05) pada KI terhadap KIV dan KV; KII terhadap KIV dan KV. Selain kelompok tersebut didapatkan perbedaan ekspresi reseptor ACE2 yang tidak signifikan (p>0.05).

Kesimpulan: Ekstrak etanolik daun kelor dengan dosis 250 mg/kgBB dan 350 mg/kgBB mampu menurunkan ekspresi reseptor ACE2 pankreas tikus wistar model sindrom metabolik secara signifikan.
Acute Pancreatitis In Type 2 Diabetes Mellitus With Multiple Stones In The Cystic Ductus
Authors: Dewi Hana Indriyah , Edya Nugraha Adhizti Naluriannisa , Marthasari Rianita , Hernawan Basundara Aditya , Putri Desy Puspa , Prabowo Nurhasan Agung 
Published: August 2023

<p><strong>Introduction:</strong> Severe upper abdominal pain is one of the symptoms of acute pancreatitis that often occurs in other diseases, such as peptic ulcer, acute hepatitis, cholangitis, and cholecystitis. Gallstone-induced acute pancreatitis has considerable morbidity and mortality.</p><p><strong>Case illustration:</strong> A 50-year-old man came to the ED with a chief complaint of severe abdominal pain in the upper abdomen, VAS 8-9. His past medical history was unknown. On arrival, blood pressure was 141/102 mmHg, pulse was 98x/minute, and temperature was 36.4ºC. CT Scan of the abdomen showed pancreatitis and multiple stones in the cystic duct. Amylase and lipase serum results were 1897U/L and &gt;3000 U/L.</p><p><strong>Discussion:</strong> In acute pancreatitis caused by gallstones, stones usually get stuck in the branches of the pancreaticobiliary duct. Obstruction at this location causes reflux of bile into the pancreatic duct. Smaller gallstones are more likely to induce pancreatitis because they migrate more easily between bile ducts. This patient was suspected of having a previously unknown history of DM, which contributed to the patient's worsening condition.</p><p><strong>Conclusion:</strong> Early management and treatment of triage, fluid resuscitation, and detection of local or systemic complications are essential. In pancreatitis due to gallstones, decisions about the need and timing of procedural intervention are critical. </p>
Boosted Mutated Corona Virus Optimization Routing Protocol (Bmcvorp) for Reliable Data Transmission with Efficient Energy Utilization
Authors: R Karthikeyan , Vadivel R. 
Published: August 2023

Abstract

The device was invented to sense the variations in the deployed Environment, which takes different dimensions in its functionality. The basic operation does not change; it is the same surveillance, gathering and alert. Human intervention in all places is not possible and efficient monitoring in all circumstances cannot be done manually. Wireless Sensor Networks give the solution for the above-specified problem, continuous efficient monitoring and alerting on time without human intervention in any circumstances. Deploying WSNs and extracting efficient performance requires a strong technology backup. However, it's a machine in logical connectivity that may face several technical issues while transferring the gathered data. It has to be rectified, and efficient service to be provided in the deployed application. Finding the safest and fastest path is one of the critical tasks in the WSN. To achieve that, Bio-Inspired Computing will be used as a tool for designing the protocol to attain the fastest reliable network, even if it deals with the other problems in WSN, such as efficient energy utilization from the battery. In such a way, the Paper is proposed based on the exceptional and exciting behavior of one of the living things, which shook the entire world for almost two years in all aspects, and even a few countries are still seeking a way to come back from its impact, the reason for global lockdown, born with the crown, founder of social distancing, which is popularly known as "Corona" the virus.
Spectral and Energy Efficiency for Uplink Massive MIMO Systems
Authors: Zeeshan Muhammad , Ahmad Ishtiaq 
Published: August 2023

Abstract
Mobile networks like 5G, 6G, and the beyond facing aggravating challenges regarding the handling of an increasing number of massive devices. In fact, a large number of terminal sends bunch of streams to small array of antennas simultaneously. This increasing burst of data traffic requires prudent handlers therefore, a large array of Multiuser Multi input and Multi out (MIMO) strategies has been proposed to handle the growing demand of mobile traffic. In the first phase, the spectral, and energy efficiency of uplinking massive MIMO system has been achieved through linear receivers which compute the factors like Minimum Mean Square Error (MMSE), Zero Forcing (ZF), and Maximum Ratio Combing (MRC). While in the second phase the relationship between received power and the base station antenna is analyzed by considering the perfect and imperfect channel state information. The outcome of the proposed method has been analyzed through MATLAB simulation which vouched that MRC receivers have performed worse than the MMSE and ZF receivers. Nonetheless, when power levels have dropped the crosstalk provided by the lower MRC cascades under the noise threshold, making the receiver a feasible option. Subsequently, the tradeoff between spectral and energy efficiency is analyzed by comparing to a small antenna array and it has been proven that by employing a fairly large antenna array i.e; 100 antennas, the energy and spectral efficiency can be enhanced by orders of 4 and 3 magnitudes respectively.
Barriers and facilitators to using procedural pain treatments in pediatric patients: protocol for a systematic review and meta-synthesis
Authors: Yan Chunji , Hu Jiale , Kang Jiamin , Xing Xueyan , Tu Shumin , Zhou Fang 
Published: August 2023

Abstract

Background The incidence of procedural pain is high in pediatric patients. Poorly treated pain will contribute to a variety of short-term and long-term adverse effects in children. There are many evidence-based effective pain treatments for reducing procedural pain, such as topical anesthetics, skin-to-skin care, sweet solutions, and breastfeeding; however, in clinical settings, the rate of using these effective procedural pain treatments is still very low. This systematic review aims to synthesize the barriers and facilitators to the implementation of effective procedural pain treatments in pediatric patients.
Methods Primary studies will be included if they report any barriers or facilitators to procedural pain treatments in pediatric patients. There are no restrictions on the year and language of publication of studies. Both published studies and grey literature will be identified. We will search published studies through Medline(OVID), EMBASE, CINAHL, PsycINFO, Web of Science, and Scopus. Grey literature will be searched through Google Scholar, OpenGrey, e-theses online service, ProQuest, WorldCat, Networked Digital Library of Theses and Dissertations, Open Access Theses and Dissertations, and public health organization websites. The Mixed Methods Appraisal Tool will be used to assess all studies' quality. The Consolidated Framework for Implementation Research will be used as a theoretical framework to code the barriers and facilitators in each study. A meta-synthesis method will be used to synthesize the findings across studies.
Discussion In this review, the CFIR framework will be used to systematically collect and analyze barriers and facilitators to procedural pain management in pediatric patients. The mixed studies review is necessary to include the heterogeneity of different studies to give us a more complete picture of the context in which the intervention was implemented. The next step could be to develop interventions that target these factors to better improve clinical outcomes for patients.
Systematic review registration CRD42022322319
Maximal detrusor pressure can be predicted using technetium-99m-mercaptoacetyltriglycin renal scintigraphy in the early stages of spinal cord injury
Authors: Shin Ji Cheol , Lee Su Ji 
Published: August 2023

Abstract
Study design: Retrospective cohort study
Objective: To investigate the potential of technetium-99m-mercaptoacetyltriglycine (99mTc-MAG-3) renal scintigraphy in predicting maximal detrusor pressure in the early stages of spinal cord injury (SCI).
Setting: Tertiary rehabilitation facility
Methods: Medical records of individuals with SCI admitted between January 202 and April 2023 who underwent both 99mTc-MAG-3 renal scintigraphy and urodynamic study within 90 days of SCI onset were retrospectively reviewed. Pearson's coefficient analysis was performed to determine the relationship between 99mTc-MAG-3 renal scintigraphy findings and urodynamic study findings. Multivariate linear regression analysis was performed to determine the best predictors of maximal detrusor pressure. Multivariate logistic regression analysis was performed to determine risk factors for high detrusor pressure.
Results: Ninety-four participants were enrolled in this study. The Pearson's correlation analysis showed that ERPF and ERPF (% predicted) were significantly correlated with maximal detrusor pressure. The multivariate linear regression analysis demonstrated that ERPF (% predicted) was a significant predictor of maximal detrusor pressure. The multivariate logistic regression analysis showed that ERPF (% predicted) was significantly associated with high detrusor pressure. Receiver operating characteristic curves demonstrated that the predictive model had an area under the curve of 0.725, and the cut-off value for ERPF (% predicted) was 64.05%, with a sensitivity of 1.000 and specificity of 0.429.
Conclusion: These results suggest that 99mTc-MAG-3 renal scintigraphy may be useful for predicting high detrusor pressure in early SCI, and may guide the timing of urodynamic studies in individuals with early SCI for appropriate management of neurogenic bladder.
Spatial Distribution of Malaria Prevalence and Predictors Among Pregnant Women in Ondo State, Southwest, Nigeria
Authors: Ekpa Dave Eleojo , Arije Olujide , Eunice Salubi , Osunde Michael Omofowa , Aluko Olufemi Oludare 
Published: August 2023

Abstract
Globally, malaria increase the rate maternal mortality. Nigeria has high malaria endemicity and the world's highest malaria burden. Nigeria reports about 51 million cases and 31.3% mortality annually, while 97% of the population (213.4m) is at risk. Malaria killed no fewer than 200,000 Nigerians, of which there were 61 million cases that were responsible for 11% of maternal mortality in Nigeria in 2021. This study examined the prevalence and patterns of malaria endemicity among pregnant women in Ondo State, and determined the malaria prevalence from 2013–2017. Geospatial technology was employed to examine the distribution of malaria cases among pregnant women and one-way Analysis of Variance (ANOVA) was used to determine the malaria prevalence in eight Local Government Areas. Temporal analysis revealed a gradual increase in malaria occurrence over the years. In 2013, 2015, and 2017, Akure South recorded the highest prevalence, with approximately 8 cases (40.11%), 5 cases (23.64%), and 9 cases (27.94%) per 1000 pregnant women, respectively. Ondo East had the highest prevalence of 9 cases (27.06%) in 2014, while in 2016, Akoko Southwest had the highest prevalence of 3 cases (19.04%) per 1000 pregnant women. The cumulative malaria patterns for the five years showed that Akure South had the highest prevalence of 18.76–31.42 per 1000 pregnant women. In contrast, the lowest prevalence occurred in Odigbo and Okitipupa having 5–9 cases per 1000 pregnant women. From 2013–2017, findings showed variations in the disease's prevalence in Ondo state.
Deoxynivalenol and T-2 toxins cause liver damage and egg quality degradation through endoplasmic reticulum stress in summer laying hens
Authors: Guo Haoneng , Wan HongYan , Lou Wenfang , Khan Rifat Ullah , You Jinming , Huang Bo , Hao Shu , Li Guanhong , Dai Sifa 
Published: August 2023

Abstract
The present study aimed to find whether low doses of mixed mycotoxins would affect egg quality in laying hens, and to explore the oxidative stress induced liver damage through endoplasmic reticulum during summer stress. A total of 96 Jinghong laying hens, 36 wks of age, were divided into four treatments, with eight repetitions per treatment and three hens per repetition. All the hens were raised in summer (average temperature: 31.3 ± 0.5℃; average humidity: 85.5 ± 0.2%) for 28d. One treatment was fed a basal diet as control (CON), and the other three treatments were fed the same diets containing 3.0 mg/kg deoxynivalenol (DON), 0.5 mg/kg T-2 toxin (T-2), and 1.5 mg/kg DON + 0.25 mg/kg T-2 toxin (Mix). Albumen height and Haugh unit were decreased (P < 0.05) in the Mix group on day 14 and 28. The activity of total antioxidant capacity, glutathione peroxidase, catalase, and superoxide dismutase were decreased (P < 0.05) in the DON, T-2, and Mix groups. The alkaline phosphatase level in DON, T-2, and Mix groups was significantly increased (P < 0.05). The level of interleukin-1β, interferon-γ, and tumor necrosis factor-α in the Mix group were higher (P < 0.05) than CON, DON, and T-2 groups. Mix group upregulated the mRNA expressions of protein kinase RNA-like ER kinase, activating transcription factor4, IL-1β, nuclear factor-κ-gene binding, and nuclear respiratory factor 2 in the liver (P < 0.05). The results showed that low doses of DON and T-2 toxin could cause oxidative stress in the liver, but DON and T-2 toxin have a cumulative effect on virulence, which can reduce egg quality and cause endoplasmic reticulum stress in the liver.
Microsatellite instability screening in colorectal carcinoma: lmmunohistochemical analysis of MMR proteins in correlation with clinicopathological features and Ki 67 protein expression.
Authors: N.Yassen Noha , Abouelfadl Dalia M. , Abbas Naglaa F. , Soliman Ahmed S.A , Shabana Marwa E. 
Published: August 2023

Abstract
Background
Defects in mismatch repair (MMR) system or microsatellite instability (MSI) and detected in colorectal carcinoma (CRC); both in sporadic and more frequently in hereditary cases. Immunohistochemistry (IHC) is the most frequent method for MMR protein deficiency screening in CRCs.
Methods
In this study, we evaluated by immunohistochemical expression of MMR proteins including MSH6, MSH2, PMS2 and MLH1 in 50 resection materials with colorectal carcinoma. Their expression is correlated with clinicopathological features of patients together, with Ki-67 protein expression in attempt to screen the most significant predictor of microsatellite instability.
Results
Of the 50 cases of cancer colon, 28% were classified as MSI-H, 20% were MSI-L and 52% were MSS. The most frequent pattern in MSI-H tumors was concurrent loss of MSH-6 and PMS-2 proteins. Significant correlation between MMR proteins expression pattern with tumor size, grade, T classification and stage (0.015, 0.0515, 0.0162 and 0.0391) respectively. MSI-H tumors were located more frequently in right colon, early TNM stage, poorly differentiated and infrequent distant metastases. There was significant correlation between Ki-67 high expression and MSI status patterns suggest in their common biological aspects distinct from MSI-negative tumors.
Conclusions
Mismatch repair defective colorectal carcinoma have characteristics clinicopathological features different from MSS tumors. The role of immunohistochemistry (IHC) for MSI evaluation is the easiest and effective way for evaluation of MMR deficiency in colorectal carcinoma
Integrated proteomics analysis in cerebrospinal fluid and saliva reveals the changes of endopeptidase activity in Parkinson`s disease
Authors: Yin Yanan , Liu Fengtao , Li Kai , Tan Subei , Zhao Jue , Sun Yimin , Feng Jinwen , Xu Ning , Tang Yilin , Yu Wenbo , Wu Jianjun , Wang Jian , Ding Chen 
Published: August 2023

Abstract
Background
The prodromal phase of Parkinson's disease can reach 10–20 years, and clinically meaningful biomarkers associated with Parkinson's disease (PD) have not been developed based on biofluid samples. Here, we aimed to identify novel biofulid candidate biomarkers by integrating CSF and saliva proteomes in PD.
Methods
We used a high-throughput tandem mass spectrometry to analyze 120 CSF samples and 203 saliva samples. Weighted gene co-expression network analysis (WGCNA) were performed to determine the protein features that are significantly correlated with the clinical parameters. Additionally, We used machine learning techniques to identify candidate biomarkers for PD diagnose.
Results
In total, we identified 2,585 and 4,301 proteins in CSF and saliva, respectively. Among these proteins, 10 differentially expressed proteins (DEPs) were in common between CSF and saliva proteome, mainly involved in the negative regulation of endopeptidase activity as well as hyaluronan metabolic. Interestingly, persistent activation of the negative regulation of endopeptidase activity during the progression of PD. WGCNA analysis revealed a significant negative correlation between AGT protein and UPDRS score in both CSF and saliva. In addition, machine learning identified a combination of 5 protein (GAPDH, GNS, ITIH2, CTSL, and GPX3) as biomarkers for PD, with an area-under-the-curve (AUC) of 0.877–0.958.
Conclusion
In summary, we integrated and analyzed the proteomes of CSF and saliva proteomes, confirming that CSF and saliva proteome could both reflect the occurrence and development of PD. Furthermore, we found that endopeptidase activity might be a potential pathogenesis of PD, especially during the progression of disease. In addition, we also discovered valuable candidate biomarkers for PD diagnosis.
Configurable Full Subtractor and Adder by Lego-like Mixing and Matching of Engineered Bacteria in an Artificial Neural Network Type Architecture
Authors: Bagh Sangram , Bonnerjee Deepro , Chakraborty Saswata 
Published: August 2023

Abstract

One of the long-term goals of synthetic bioengineering is to create configurable and programmable biological systems by just mixing and matching "LEGO"-like bio-modules. Here, we introduce a configurable and modular multi-cellular system where, from a small library of nine discrete engineered bacterial cells, a full subtractor, which subtract binary numbers and a full adder, which adds binary numbers can be built on demand by just mixing and matching seven appropriate cell types in a culture. Here, each set of engineered bacteria was modelled as an ‘artificial neuro-synapse’ that, in a co-culture, formed a single layer artificial neural network (ANN) type architecture that worked as a biochemical full subtractor or full adder. The system is configurable with interchangeable cellular modules, whereby through simply interchanging two cell types in the subtractor culture, a full adder can be built and vice versa. This Lego-like mix and match system is mathematically predictive, and the physical scaling up of the whole system was achieved by directly applying mathematical scale up of the cellular modules. This work provides a flexible and scalable means to build complex cellular functions and may have significance in biocomputer technology development, multi-cellular synthetic biology, and cellular hardware for ANN.