bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lower SLC7A2 expression is associated with enhanced multidrug resistance, less immune infiltrates and worse prognosis of NSCLC
Authors: Jiang Shanshan , Zou Junrong , Dong Jianyu , Shi Huimian , Chen Jie , Li Yan , Duan Xianglong , Li Wensheng 
Published: January 2023

Abstract
Background
Solute carrier family 7 member 2 (SLC7A2), a cationic amino acid transporter, is lowly expressed in ovarian and hepatocellular cancers, which is associated with their worse prognosis. However, its roles in the prognosis, drug resistance and immune infiltration in non-small-cell lung cancer (NSCLC) are unclear.

Methods
We chose SLC7A2 from RNA-Seq of paclitaxel/cisplatin-resistant A549 cells, then bioinformatics, cell lines construction, RT-qPCR, and CCK8 were performed to investigate SLC7A2 role.

Result
We analyzed the 223 differentially expressed genes (DEGs) from RNA-Seq of paclitaxel/cisplatin-resistant A549 cells and found that SLC7A2 expression was down-regulated in NSCLC. Lower SLC7A2 expression was associated with worse recurrence-free survival (RFS) in NSCLC. SLC7A2 silencing enhanced the proliferation of NSCLC cells and their insensitivity to paclitaxel, cisplatin, and gemcitabine in vitro. Activation of AMPK has up-regulated SLC7A2 expression and enhanced the sensitivity of NSCLC cells to anti-tumor drugs, which could be attributed to E2F1’s regulation. In addition, the levels of SLC7A2 expression were correlated to the numbers of infiltrated neutrophils, macrophages, dendritic cells and their marker genes, like CD86, HLA-DPA1 and ITGAM.

Conclusions
SLC7A2 may act as a tumor suppressor to modulate drug sensitivity, immune infiltration and survival in NSCLC.
Novel fondaparinux protocol for anticoagulation therapy in adults with renal failure and suspected heparin-induced thrombocytopenia: a retrospective review of institutional protocol
Authors: Ghaziri Dania , Dehaini Hassan , Msheik Mayyas , Bahmad Marwan , Zorkot Maya , Saad George Abi 
Published: January 2023

AbstractIntroductionThe literature recommends against the use of fondaparinux in patients with kidney failure and dialysis as it may, with repeated dosing, accumulate and put patients at risk of bleeding. The management of patients with thrombosis in the presence of heparin-induced thrombocytopenia HIT requires the introduction of an alternative anticoagulant like bivalirudin or argatroban. When these drugs are not available, fondaparinux, remains the only alternative. In similar scenarios, there are few studies addressing how to administer it. MethodsWe developed a protocol for fondaparinux in patients with renal failure where pharmacokinetic parameters are altered, and levels changed only after hemodialysis or in cases of residual renal activity. Patients received a full first dose except for high risk of bleeding. We targeted a peak anti-factor Xa activity level of 0.6–1.3 units/ml and changed the subsequent dose accordingly. Furthermore, we monitored the patients for signs of bleeding, a drop in hemoglobin level, or clinical signs of thrombosis. DiscussionWe described 10 patients with kidney failure and suspected HIT taking fondaparinux. All the patients achieved therapeutic anti-factor Xa activity levels. However, one developed new-onset venous thromboembolism (VTE) despite therapeutic anti-factor Xa levels. Another patient experienced a bleeding episode. We believe that these two patients developed complications due to their medical conditions rather than the use of fondaparinux.ConclusionFondaparinux can be safely used in kidney failure using our protocol. However, despite its safety profile and relative success, this case series was small. More robust studies need to be conducted prior to drawing conclusions.
Aquatic therapy following arthroscopic rotator cuff repair enables faster improvement of Constant score than land‐based therapy or self‐rehabilitation therapy
Authors: Cikes Alec , Kadri Fayssal , van Rooij Floris , Lädermann Alexandre 
Published: January 2023

AbstractPurposeTo compare the clinical and functional outcomes of arthroscopic rotator cuff repair over a period of 2 years using three postoperative rehabilitation modalities: aquatic therapy, land‐based therapy, and self‐rehabilitation therapy. The null hypothesis was that aquatic therapy would provide no difference in Constant score compared to land‐based therapy and self‐rehabilitation therapy.MethodsA prospective study was performed on subjects scheduled for arthroscopic rotator cuff repair between 2012 and 2017 that complied with the following criteria: (i) small to medium sized symptomatic supraspinatus and/or infraspinatus tendon tears, (ii) low to moderate tendon retraction according to Patte, and (iii) fatty infiltration stage ≤2. Patients were allocated to perform either aquatic therapy, land‐based therapy, or self‐rehabilitation therapy for 2‐4 months. Independent observers blinded to the study design collected Constant score, SSV, and patient satisfaction at 2 months, 3 months, 6 months, 1 year and 2 years.Study designLevel III, cohort studyResultsAt 2 months follow‐up, patients performing aquatic therapy had significantly higher Constant scores (p < 0.001) and SSV (p < 0.001) compared to those performing land‐based therapy or self‐rehabilitation therapy. At 3 months follow‐up, patients performing aquatic therapy had significantly higher Constant scores (p < 0.001), and SSV (p < 0.001), both of which exceeded the respective minimal clinically important differences (MCIDs) of 10.4 and 12. Patients performing aquatic therapy continued to have significantly higher Constant scores and SSV at 6 months, 1 year, and 2 years.ConclusionAquatic therapy has a positive effect on clinical outcomes at 3 months after surgery, but yields no relevant improvements on function or satisfaction at 1 to 2 years follow‐up.
Exploring the asymmetric effect of COVID-19 pandemic news on the cryptocurrency market: evidence from nonlinear autoregressive distributed lag approach and frequency domain causality
Authors: Gherghina Ştefan Cristian , Simionescu Liliana Nicoleta 
Published: January 2023

AbstractThis paper explores the asymmetric effect of COVID-19 pandemic news, as measured by the coronavirus indices (Panic, Hype, Fake News, Sentiment, Infodemic, and Media Coverage), on the cryptocurrency market. Using daily data from January 2020 to September 2021 and the exponential generalized autoregressive conditional heteroskedasticity model, the results revealed that both adverse and optimistic news had the same effect on Bitcoin returns, indicating fear of missing out behavior does not prevail. Furthermore, when the nonlinear autoregressive distributed lag model is estimated, both positive and negative shocks in pandemic indices promote Bitcoin’s daily changes; thus, Bitcoin is resistant to the SARS-CoV-2 pandemic crisis and may serve as a hedge during market turmoil. The analysis of frequency domain causality supports a unidirectional causality running from the Coronavirus Fake News Index and Sentiment Index to Bitcoin returns, whereas daily fluctuations in the Bitcoin price Granger affect the Coronavirus Panic Index and the Hype Index. These findings may have significant policy implications for investors and governments because they highlight the importance of news during turbulent times. The empirical results indicate that pandemic news could significantly influence Bitcoin’s price.
Transesophageal echocardiography for cardiac herniation occurring during robotic-assisted mitral valve repair: a case report
Authors: Miyata Kazuto , Shigematsu Sayaka , Miyayama Naoki 
Published: January 2023

Abstract
Background
Cardiac herniation has been reported in thoracic trauma and after pneumonectomy; however, it is sporadic in cardiac surgery.

Case presentation
A 35-year-old male patient underwent an elective totally endoscopic robotic-assisted mitral valve repair (TERMVR). His hemodynamics were stable after weaning from cardiopulmonary bypass, and no residual mitral valve regurgitation was observed. However, during suturing of the port wound, the patient developed hypotension, which improved with phenylephrine administration. Four-chamber transesophageal echocardiography (TEE) images showed cardiac deformity, and postoperative chest radiography confirmed the dextrocardia. The cardiac herniation was repaired by deflating the left lung and over-inflating the right lung using a double-lumen tube, allowing selective ventilation without re-thoracotomy. The patient was discharged on the sixth postoperative day without complications.

Conclusions
This was a very unusual case of cardiac herniation during TERMVR visualized using distinct TEE images. The cardiac herniation was successfully repaired using a double-lumen tube without re-thoracotomy.
Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies
Authors: Melki Saifeddine , Moulinet Thomas , Verger Antoine , Marie Pierre-Yves , Imbert Laetitia , Bahloul Achraf 
Published: January 2023

AbstractErdheim-Chester disease (ECD) is a rare histiocytosis due to proto-oncogene mutations, primarily affecting the long bones and possibly being treated by novel targeted therapies. 18F-FDG PET is a reference technique for ECD assessment. However, we present a case where easier and more objective monitoring of the ECD-related bone metabolism abnormalities under treatment was obtained with the standardized uptake value-based information provided by fast whole-body [Tc-99 m]-HDP bone tomoscintigraphies (QWBT) recorded with a high-sensitivity CZT-camera/computed tomography (CT) hybrid system.
Reflex seizures induced by micturition: a case report
Authors: Zhang Zhiyun , Li Qiwei , Jiang Tiejia , Fang Jiajia 
Published: January 2023

Abstract
Background
Reflex seizures (RS) induced by micturition are extremely rare, and the clinical and electroencephalogram features of RS are not widely known among clinicians. In particular, the origin of the epileptic area is still unclear.

Case presentation
An 8-year-old girl who had generalized tonic-clonic seizures was diagnosed with RS induced by micturition based on the clinical manifestation and EEG recordings. We also reviewed the clinical and EEG characteristics of RS induced by micturition in literature by searching the databases of PubMed and MEDLINE using keywords “micturition reflex seizure”, “reflex seizure induced by micturition”, and “micturition induced seizure” by January 2022. We speculate that the mechanism of micturition-induced RS may involve excessive neuronal excitation in regions that participate in micturition.

Conclusions
The RS in this patient was considered to be induced by micturition. Awareness should be raised to this rare form of RS among practitioners.
Granulation tissue after otologic surgeries: a cross-sectional report on the incidence and management
Authors: Rajati Mohsen , Nazarpour Parisa , Afzalzadeh Mohamad Reza 
Published: January 2023

Abstract
Background
Granulation tissue (GT) formation is a complication of otologic surgeries. We aimed to assess the rate of GT formation following these procedures and their outcome.

Methods
This cross-sectional study was performed from 2015 to 2019. Patients who underwent tympanomastoidectomy (either CWD or ICW) and stapedotomy were included. Demographic and other related data were gathered. Four weeks after surgery, patients were assessed for any sign of granulation tissue formation. If present, they were managed topically and were followed every 2 months until complete resolution.

Results
Of 1045 included cases, 200 underwent Canal Wall Down (CWD) mastoidectomy, 568 underwent Intact Canal Wall (ICW) mastoidectomy, and 277 experienced stapedotomy. Four weeks after surgery, 180 participants were diagnosed with GT (17.22%). The incidence rate of GT formation following tympanomastoidectomy and stapedotomy is 23.44% and 0%, respectively. This measure is 43% and 16.5% for CWD, and ICW approaches. Following treatment for 2 months, we found 164 (91.1%) participants with complete resolution at the second visit. Of the remaining 16 cases, 10 and 6 were cured at the third and fourth visits. Males developed GT significantly more (p < 0.001).

Conclusion
Those with CWD mastoidectomy are more likely to develop GT than ICW and stapedotomy surgeries. It has a favorable response to conservative topical management.
International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood
Authors: Hokken-Koelega Anita C S , van der Steen Manouk , Boguszewski Margaret C S , Cianfarani Stefano , Dahlgren Jovanna , Horikawa Reiko , Mericq Veronica , Rapaport Robert , Alherbish Abdullah , Braslavsky Debora , Charmandari Evangelia , Chernausek Steven D , Cutfield Wayne S , Dauber Andrew , Deeb Asma , Goedegebuure Wesley J , Hofman Paul L , Isganatis Elvira , Jorge Alexander A , Kanaka-Gantenbein Christina , Kashimada Kenichi , Khadilkar Vaman , Luo Xiao-Ping , Mathai Sarah , Nakano Yuya , Yau Mabel 
Published: January 2023

AbstractThis International Consensus Guideline was developed by experts in the field of small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus meeting was held and 1300 articles formed the basis for discussions. All experts voted about the strengths of the recommendations. The guideline gives new and clinically relevant insights into the etiology of short stature after SGA birth, including novel knowledge about (epi)genetic causes. Further, it presents long-term consequences of SGA birth and also reviews new treatment options, including treatment with gonadotropin-releasing hormone agonist (GnRHa) in addition to growth hormone (GH) treatment, as well as the metabolic and cardiovascular health of young adults born SGA after cessation of childhood GH treatment in comparison with appropriate control groups.To diagnose SGA, accurate anthropometry and use of national growth charts are recommended. Follow-up in early life is warranted and neurodevelopment evaluation in those at risk. Excessive postnatal weight gain should be avoided, as this is associated with an unfavorable cardiometabolic health profile in adulthood. Children born SGA with persistent short stature &lt; −2.5 SDS at age 2 years or &lt; −2 SDS at 3 to 4 years of age, should be referred for diagnostic workup. In case of dysmorphic features, major malformations, microcephaly, developmental delay, intellectual disability, and/or signs of skeletal dysplasia, genetic testing should be considered. Treatment with 0.033 to 0.067 mg GH/kg/day is recommended in case of persistent short stature at age of 3 to 4 years. Adding GnRHa treatment could be considered when short adult height is expected at pubertal onset. All young adults born SGA require counseling to adopt a healthy lifestyle.
Neurosurgical Outcomes for Pediatric Central Nervous System Tumors in the United States
Authors: Chalif Eric J. , Morshed Ramin A. , Oh Taemin , Dalle Ore Cecilia , Aghi Manish K. , Gupta Nalin 
Published: January 2023

BACKGROUND:
Limited data exist on pediatric central nervous system (CNS) tumors, and the results from the National Cancer Database, the largest multicenter national cancer registry, have not previously been comprehensively reported.

OBJECTIVE:
To capture pediatric neurosurgical outcomes and investigate possible disparities of care.

METHODS:
The National Cancer Database was queried for pediatric patients who were diagnosed with CNS tumors from 2004 to 2018. Primary outcomes included 30/90 days postoperative mortality (30M/90M), readmission within 30 days of discharge (30R), and length of inpatient stay (LOS).

RESULTS:
Twenty four thousand nine hundred thirty cases met the inclusion criteria, of which were 4753 (19.1%) juvenile pilocytic astrocytomas, 3262 (13.1%) medulloblastomas, 2200 (8.8%) neuronal/mixed neuronal-glial tumors, and 2135 (8.6%) ependymal tumors. Patients aged 0 to 4 years had significantly poorer outcomes than patients in older age groups (90M: 3.5% vs 0.7%-0.9%; 30R: 6.5% vs 3.6%-4.8%; LOS: 12.0 days vs 6.0-8.9 days). Tumor size was a strong predictor of poor outcomes with each additional cm in diameter conferring a 26%, 7%, and 23% increased risk of 90M, 30R, and prolonged LOS, respectively. Data over the study period demonstrated year over year improvements of 4%, 3%, and 2%, respectively, for 90M, 30R, and prolonged LOS. Facilities with a high volume of pediatric tumor cases had improved 90M (1.1% vs 1.5%, P = .041) and LOS (7.6 vs 8.6 days, P < .001). Patients with private health insurance had better outcomes than patients with government insurance.

CONCLUSION:
There is substantial variability in surgical morbidity and mortality of pediatric CNS tumors. Additional investigation is warranted to reduce outcome differences that may be based on socioeconomic factors.
Association of Preoperative Vascular Wall Imaging Patterns and Surgical Outcomes in Patients With Unruptured Intracranial Saccular Aneurysms
Authors: Hu Liuxun , Quan Kai , Shi Yuan , Liu Peixi , Song Jianping , Tian Yanlong , An Qingzhu , Liu Yingjun , Li Sichen , Yu Guo , Fan Zhiyuan , Luo Jianfeng , Gu Yuxiang , Xu Bin , Zhu Wei , Mao Ying 
Published: January 2023

BACKGROUND:
MR vascular wall imaging (VWI) may have prognostic value in patients with unruptured intracranial aneurysms (UIAs).

OBJECTIVE:
To evaluate the value of VWI as a predictor of surgical outcome in patients with UIAs.

METHODS:
This prospective cohort study evaluated surgical outcomes in consecutive patients with UIAs who underwent surgical clipping at a single center. All participants underwent high-resolution VWI and were followed for at least 6 months. The primary clinical outcome was modified Rankin scale (mRS) score 6 months after surgery.

RESULTS:
The number of patients in the no wall enhancement, uniform wall enhancement (UWE), and focal wall enhancement (FWE) groups was 37, 145, and 154, respectively. Incidence of postoperative complications was 15.5% in the FWE group, 12.4% in the UWE group, and 5.4% in the no wall enhancement group. The proportion of patients with mRS score >2 at the 6-month follow-up was significantly higher in the FWE group than in the UWE group (14.3% vs 6.9%; P = .0389). In the multivariate analysis, FWE (odds ratio, 2.573; 95% CI 1.001-6.612) and positive proximal artery remodeling (odds ratio, 10.56; 95% CI 2.237-49.83) were independent predictors of mRS score >2 at the 6-month follow-up.

CONCLUSION:
Preoperative VWI can improve the surgeon's understanding of aneurysm pathological structure. Type of aneurysmal wall enhancement on VWI is associated with clinical outcome and incidence of salvage anastomosis and surgical complications.
Comparing Impact and Concussion Risk in Leatherhead and Modern Football and Hockey Helmets
Authors: Huang Jaxon J. , Goya Kellie N. , Yamamoto Brennan E. , Yamamoto Loren G. 
Published: January 2023

BACKGROUND:
Improvements in the modern helmet have demonstrated beneficial effects in reducing concussion risk in football players. However, previous studies yield conflicting results regarding the protective quality of leatherhead football helmets. There is limited research comparing the modern football helmet and the modern hockey helmet, with one previous study demonstrating the football helmet as providing a lower risk of concussion.

OBJECTIVE:
To compare the head acceleration produced in a leatherhead football helmet vs a modern football helmet vs a modified modern football helmet with softer padding vs a modern hockey helmet in helmet-to-helmet strikes.

METHODS:
Accelerometers were placed on the frontal, apex, and parietal regions of a Century Body Opponent Bag manikin. Each type of helmet was placed on the manikin and struck by a swinging modern football helmet. The G-force acceleration was determined in three-dimensional axes of 100 total helmet-to-helmet impacts.

RESULTS:
The leatherhead football helmet was the least protective in reducing G-forces. The modified modern football helmet did not provide a significant difference compared with the modern football helmet. Significantly greater G-forces were produced in a collision between 2 modern football helmets in comparison with 2 modern hockey helmets.

CONCLUSION:
The leatherhead football helmet was the least protective, and the hockey helmet was the most protective, with the football helmet being intermediate. This study provides additional insight into the inconclusive evidence regarding the safety of leatherhead football helmets and into the design of football and hockey helmets in the future.
The Evolution of Endoscopic Endonasal Approach for Olfactory Groove Meningiomas
Authors: Champagne Pierre-Olivier , Zenonos Georgios A. , Wang Eric W. , Snyderman Carl H. , Gardner Paul A. 
Published: January 2023

BACKGROUND:
There is controversy over the choice of optimal approach for olfactory groove meningiomas (OGM). The endoscopic endonasal approach (EEA) is one of the most recently described corridors, which provides direct access to the tumor base.

OBJECTIVE:
To detail the evolution of the endoscopic endonasal technique over the past 2 decades and demonstrate the impact of this evolution on patient outcomes.

METHODS:
This is a retrospective study based on a prospectively maintained database of consecutive cases of OGM operated on at our institution via EEA. For analysis, the whole cohort has been divided into 3 equal “eras” according to the time period during which the surgery happened, creating early, middle, and contemporary groups.

RESULTS:
Seventy-five patients were included, 25 in each group. The rate of postoperative cerebrospinal fluid leak significantly decreased over time (28%, 32%, and 8% in the early, middle, and contemporary groups, respectively, P = .020). The rate of postoperative encephalomalacia was significantly lower in more recent groups (24%, 16%, and 0% in the early, middle, and contemporary groups, respectively, P = .029), as was the time to resolution of postoperative brain edema (103.9 months, 87.3 months, and 16.8 months in the early, middle, and contemporary groups, respectively, P = .020).

CONCLUSION:
The endoscopic endonasal approach for OGM significantly evolved over time, achieving lower cerebrospinal fluid leak rates while providing a high rate of Simpson grade 1 resection. Technical improvements minimized the frontal lobe impact. Current data support EEA as a safe and effective corridor to treat OGM.