bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age Differences in Self-Continuity in Germany and the United States: The Role of Temporal Direction, Temporal Distance, and Demographics
Authors: Lu Yi , Gerstorf Denis , Löckenhoff Corinna E 
Published: January 2023

Abstract

Objectives
Previous research suggests that self-continuity is higher in older ages, especially for more distant intervals. This study extends prior work by examining age and temporal patterns of self-continuity in 2 adult life-span samples from Germany and the United States.

Methods
German data (n = 1,656, aged 18–93) were drawn from the German Socioeconomic Panel. U.S. data (n = 230, aged 18–87) were collected through a survey research firm. Preregistered multilevel analyses examined the roles of age, temporal direction (past/future), and temporal distance (1/5/10 years), and explored the role of demographic covariates.

Results
In both data sets, self-continuity was higher in older ages and decreased with distance from the present, especially for the past. Interaction effects among age, temporal distance, and temporal directions were complex and varied across samples. Self-continuity was higher among married and more educated German participants and more affluent U.S. participants, but age differences remained robust when including demographic covariates.

Discussion
Findings replicate prior evidence for age-related increments in self-continuity but suggest that patterns vary by temporal distance and direction and may be sensitive to contextual factors.
An alternative method for estimating effective elastic thickness by the Vening Meinesz regional isostatic theory with application to continents
Authors: Zhang Xingyu , Kaban Mikhail K , Chen Chao , Liang Qing 
Published: January 2023

SUMMARYEffective elastic thickness, ${T_\mathrm{ e}}$, is a measure of the lithosphere's mechanical strength, and describes the flexural response of the lithosphere to applied loads in the same way as a thin elastic plate. In this study, a new method for estimating ${T_\mathrm{ e}}$ in the spatial domain is presented based on the Veining Meinesz regional isostatic theory. By comparing the absolute values of the correlation coefficients between the observed Moho flexure model and different Veining Meinesz Moho flexure models, the optimal ${T_\mathrm{ e}}$ is determined. Also, the estimated correlation coefficients can be used to examine the effect of the unknown subsurface loads, which are usually difficult to evaluate in the spatial domain. This method is verified to be capable of recovering ${T_\mathrm{ e}}$ variations through synthetic tests for the models with predefined ${T_\mathrm{ e}}$ variations. Finally, the effective elastic thickness is globally determined for the continents using the topography data and recent seismically-derived Moho model. These results are compared with two published ${T_\mathrm{ e}}$ models obtained with different methods. For the areas with relatively small Moho uncertainties and high correlation coefficients, the estimated ${T_\mathrm{ e}}$ variations generally agree with previous results. The differences between three ${T_\mathrm{ e}}$ estimates could characterize the advantages of different methods in specific cases.
Comment on ‘Geophysical inversion and optimal transport’ by M. Sambridge, A. Jackson and A. P. Valentine
Authors: Okazaki Tomohisa , Ueda Naonori 
Published: January 2023

SUMMARY
A similarity measure between waveforms developed by Sambridge et al. realized an effective use of optimal transport as well as computational efficiency through the marginalization of a 2-D probability distribution obtained from a seismogram. We demonstrate that information loss due to marginalization could lead to significant non-uniqueness in the resulting measure and propose the use of the sliced Wasserstein distance as a potential solution. This formulation may enhance the robustness of the method developed by Sambridge et al. by maintaining its computational efficiency.
Benefits and challenges of consolidating public health functions into a National Public Health Institute: a policy analysis
Authors: Carnevale Caroline R , Woldetsadik Mahlet A , Shiver Arielle , Gutierrez Margaret , Chhea Chhorvann , Ilori Elsie , Jani Ilesh , MaCauley Jane , Mukonka Victor , Nsanzimana Sabin , Ospina Martha Lucia , Raji Tajudeen , Spotts Whitney Ellen A , Bratton Shelly 
Published: January 2023

Abstract
National Public Health Institutes (NPHIs) around the world vary in composition. Consolidated organizational models can bring together critical functions such as disease surveillance, emergency preparedness and response, public health research, workforce development and laboratory diagnosis within a single focal point. This can lead to enhanced coordination and management of resources and enable more efficient and effective public health operations. We explored stakeholders’ perceptions about the benefits and challenges of consolidating public health functions in an NPHI in seven countries where the US Centers for Disease Control and Prevention has supported NPHI establishment and strengthening. From August 2019 through January 2020, we interviewed a total of 96 stakeholders, including NPHI staff (N = 43), non-NPHI government staff (N = 29) and non-governmental and international organization staff (N = 24) in Cambodia, Colombia, Liberia, Mozambique, Nigeria, Rwanda and Zambia. We conducted a policy analysis using Tea Collins’s health policy analysis framework to assess various possible options for coordinating public health functions and their likely effectiveness. The findings can be used by policymakers as they consider public health infrastructure. We found that consolidating functions in an NPHI, to the extent politically and organizationally feasible, promotes efficiency, flexibility and coordination, as well as supports data-driven health recommendations to government decision makers. Countries pursuing NPHI establishment can weigh the potential challenges and benefits of consolidating functions when determining which public health functions will comprise the NPHI, including clarity of role, access to resources, influence over decisions and political viability.
Effectiveness of Workplace Health Promotion (WHP) interventions in university employees: a scoping review
Authors: Moroni Alessia , Degan Raffaella , Martin Barbara , Sciannameo Veronica , Berchialla Paola , Gilli Giorgio , Micheletti Cremasco Margherita 
Published: January 2023

Summary
Workplace Health Promotion (WHP) interventions proved to be effective in several workplace contexts. Currently, the effectiveness of such interventions in the academic workplace is lacking, albeit evidence suggests similar patterns to those occurring in other workplace sectors. The aim of this study was to review WHP interventions in the university workplace that led to improve health- and work-related outcomes. Articles were selected using Pubmed, Web of Science, Scopus, Embase, PsycInfo, Cinhal and FSTA, using search strings focused on health- and/or work-related outcomes and involving University WHP interventions published between January 2010 and July 2021. The majority of the 12 studies selected reported positive results in their individuality, especially regarding health-related outcomes [biological such as weight loss, physical activity, mental health and lifestyle habits] and work-related outcomes concerning improvements either for the employee or for the working system. Studies on economic advantage and Return on Investment were limited and reported contrasting results. In conclusion, we have highlighted how the studies on effectiveness of WHP interventions in the university context are few and heterogeneous and need to be encouraged further research in order to build specific guidelines that are effective.
Considering social inequalities in health in COVID-19 response: insights from a French case study
Authors: Richard Zoé , Chabrol Fanny , Gautier Lara , Zinszer Kate , Ridde Valéry 
Published: January 2023

SummaryThe COVID-19 pandemic highlighted the impact of social inequalities in health (SIH). Various studies have shown significant inequalities in mortality and morbidity associated with COVID-19 and the influence of social determinants of health. The objective of this qualitative case study was to analyze the consideration of SIH in the design of two key COVID-19 prevention and control interventions in France: testing and contact tracing. Interviews were conducted with 36 key informants involved in the design of the intervention and/or the government response to the pandemic as well as relevant documents (n = 15) were reviewed. We applied data triangulation and a hybrid deductive and inductive analysis to analyze the data. Findings revealed the divergent understandings and perspectives about SIH, as well as the challenges associated with consideration for these at the beginning stages of the pandemic. Despite a shared concern for SIH between the participants, an epidemiological frame of reference dominated the design of the intervention. It resulted in a model in which consideration for SIH appeared as a complement, with a clinical goal of the intervention: breaking the chain of COVID-19 transmission. Although the COVID-19 health crisis highlighted the importance of SIH, it did not appear to be an opportunity to further their consideration in response efforts. This article provides original insights into consideration for SIH in the design of testing and contact-tracing interventions based upon a qualitative investigation.
Walking and perception of green space among older adults in Japan: subgroup analysis based self-efficacy
Authors: Encho Haruhi , Uchida Kazuaki , Horibe Kana , Nakatsuka Kiyomasa , Ono Rei 
Published: January 2023

Summary
Self-efficacy is the key factor for promoting physical activity. Older adults with low self-efficacy tend to be physical inactive than those with high self-efficacy, and an approach is needed to promote physical activity. Among several approaches, increasing the perception of green space may be an effective approach for low self-efficacy not high self-efficacy, but no study has investigated. This study investigated the association between walking and perception of green space among older adults with high and low self-efficacy, respectively. We conducted a cross-sectional study among 204 community-dwelling older adults (mean age = 78.3 years, 62.3% females). Using the median split, the participants were divided into high and low self-efficacy groups based on the median score of 12. Walking was measured using the International Physical Activity Questionnaire and ‘more walking’ was defined as ≥150 min of walking time per week. Perception of green space was measured using an 8-item questionnaire. We performed logistic regression analysis to investigate the association between walking and perception of green space adjusted for age, gender, years of education, living with someone and income level. For all participants, 94 participants (46.1%) fell under low self-efficacy. After adjustment, higher perception of green space is associated with more walking among older adults with low self-efficacy [adjusted odds ratio (aOR) = 1.07, 95% confidence interval (CI) = 1.00–1.15], but not among those with high self-efficacy (aOR = 1.09, 95% CI= 0.99–1.20). To increase perception of green space, experts should design/improve green spaces considering beneficiaries’ characteristics.
Women, alcohol consumption and health promotion: the value of a critical realist approach
Authors: Kersey Kate , Hutton Fiona , Lyons Antonia C 
Published: January 2023

Summary
Research on women’s drinking occurs in largely disparate disciplines—including public health, health promotion, psychology, sociology, and cultural studies—and draws on differing philosophical understandings and theoretical frameworks. Tensions between the aims and paradigmatic underpinnings of this research (across and within disciplines) have meant that knowledge and insight can be frequently disciplinary-specific and somewhat siloed. However, in line with the social and economic determinants of the health model, alcohol research needs approaches that can explore how multiple gender-related factors—biological, psycho-social, material, and socio-cultural—combine to produce certain drinking behaviours, pleasures and potential harms. We argue that critical realism as a philosophical underpinning to research can accommodate this broader conceptualization, enabling researchers to draw on multiple perspectives to better understand women’s drinking. We illustrate the benefit of this approach by presenting a critical realist theoretical framework for understanding women’s drinking that outlines interrelationships between the psychoactive properties of alcohol, the role of embodied individual characteristics and the material, institutional and socio-cultural contexts in which women live. This approach can underpin and foster inter-disciplinary research collaboration to inform more nuanced health promotion practices and policies to reduce alcohol-related harm in a wide range of women across societies.
G3BP1-dependent mechanism suppressing protein aggregation in Huntington’s models and its demise upon stress granule assembly
Authors: Gutiérrez-Garcia Ricardo , Koyuncu Seda , Hommen Franziska , Bilican Saygın , Lee Hyun Ju , Fatima Azra , Vilchez David 
Published: January 2023

Abstract
Stress granules are membrane-less ribonucleoprotein organelles that assemble upon exposure to stress conditions, but rapidly disassemble upon removal of stress. However, chronic stress can lead to persistent stress granules, a feature of distinct age-related neurodegenerative disorders. Among them, Huntington’s disease (HD), which is caused by mutant expansion of the polyglutamine (polyQ) repeats of huntingtin protein (HTT), leading to its aggregation. To identify modulators of mutant HTT aggregation, we define its interactome in striatal neurons differentiated from patient-derived induced pluripotent stem cells (HD-iPSCs). We find that HTT interacts with G3BP1, a characteristic component of stress granules. Knockdown of G3BP1 increases mutant HTT protein levels and abolishes the ability of iPSCs as well as their differentiated neural counterparts to suppress mutant HTT aggregation. Moreover, loss of G3BP1 hastens polyQ-expanded aggregation and toxicity in the neurons of HD C. elegans models. Likewise, the assembly of G3BP1 into stress granules upon distinct stress conditions also reduces its interaction with HTT in human cells, promoting mutant HTT aggregation. Notably, enhancing the levels of G3BP1 is sufficient to induce proteasomal degradation of mutant HTT and prevent its aggregation, whereas the formation of stress granules blocks these ameliorative effects. In contrast, a mutant G3BP1 variant that cannot accumulate into granules retains its capacity to prevent mutant HTT aggregation even when the cells assemble stress granules. Thus, our findings indicate a direct role of G3BP1 and stress granule assembly in mutant HTT aggregation that may have implications for HD.
High-quality haplotype-resolved genome assembly of cultivated octoploid strawberry
Authors: Mao Jianxin , Wang Yan , Wang Baotian , Li Jiqi , Zhang Chao , Zhang Wenshuo , Li Xue , Li Jie , Zhang Junxiang , Li He , Zhang Zhihong 
Published: January 2023

AbstractCultivated strawberry (Fragaria × ananassa), a perennial herb belonging to the family Rosaceae, is a complex octoploid with high heterozygosity at most loci. However, there is no research on the haplotype of the octoploid strawberry genome. Here we aimed to obtain a high-quality genome of the cultivated strawberry cultivar, “Yanli”, using single molecule real-time sequencing and high-throughput chromosome conformation capture technology. The “Yanli” genome was 823 Mb in size, with a long terminal repeat assembly index of 14.99. The genome was phased into two haplotypes, Hap1 (825 Mb with contig N50 of 26.70 Mb) and Hap2 (808 Mb with contig N50 of 27.51 Mb). Using the combination of Hap1 and Hap2, we obtained for the first time a haplotype-resolved genome with 56 chromosomes for the cultivated octoploid strawberry. We identified a ~ 10 Mb inversion and translocation on chromosome 2-1. 104 957 and 102 356 protein-coding genes were annotated in Hap1 and Hap2, respectively. Analysis of the genes related to the anthocyanin biosynthesis pathway revealed the structural diversity and complexity in the expression of the alleles in the octoploid F. × ananassa genome. In summary, we obtained a high-quality haplotype-resolved genome assembly of F. × ananassa, which will provide the foundation for investigating gene function and evolution of the genome of cultivated octoploid strawberry.
Histones of Neutrophil Extracellular Traps Directly Disrupt the Permeability and Integrity of the Intestinal Epithelial Barrier
Authors: Lai Hsuan-Ju , Doan Ha T , Lin Elliot Y , Chiu Yi-Ling , Cheng Yuan-Kai , Lin Yi-He , Chiang Hao-Sen 
Published: January 2023

Abstract

Background
Increased neutrophil extracellular trap (NET) formation and abundant NET-associated proteins are frequently found in the inflamed colon of patients with inflammatory bowel disease. Peptidyl arginine deiminase 4 (PAD4) activation is essential for the generation of NET and NET-mediated pathogenesis. However, the role of PAD4-dependent NET formation in murine inflammatory bowel disease models and the molecular mechanisms responsible for the altered gut barrier function are unknown.

Methods
Wild-type and Pad4 knockout (Pad4-/-) mice were administrated 3% dextran sulfate sodium (DSS) in their drinking water. Caco-2 monolayers were used to test the effect of NETs on intestinal barrier function and cytotoxicity. Histones were intrarectally administrated to wild-type mice to determine their effects on intestinal barrier function and cytotoxicity in vivo.

Results
PAD4 deficiency reduced the severity of DSS-induced colitis with decreased intestinal NET formation and enhanced gut barrier function and integrity in mice. NETs disrupted the barrier function in intestinal epithelial Caco-2 monolayers through their protein, rather than DNA, components. Pretreatment of NETs with histone inhibitors abrogated the effects on epithelial permeability. Consistent with these observations, adding purified histone proteins to Caco-2 monolayers significantly damaged epithelial barrier function, which was associated with the abnormal distribution and integrity of tight junctions as well as with increased cell death. Furthermore, intrarectal administration of histones damaged the intestinal barrier integrity and induced cytotoxicity in the mouse colon epithelium.

Conclusions
PAD4-mediated NET formation has a detrimental role in acute colitis. NET-associated histones directly inhibit intestinal barrier function, resulting in cytotoxicity in vitro and in vivo.
Influence of HLADQA1*05 Genotype in Adults With Inflammatory Bowel Disease and Anti-TNF Treatment With Proactive Therapeutic Drug Monitoring: A Retrospective Cohort Study
Authors: Fuentes-Valenzuela Esteban , García-Alonso Francisco Javier , Maroto-Martín Carlos , Juan Casamayor Laura , Garrote José Antonio , Almendros Muñoz Rosendo , De Prado Ángel , Vara Castrodeza Alejando , Marinero María Ángeles , Calleja Carbajosa Raquel , Barrio Jesús 
Published: January 2023

Abstract

Background
Carriers of the human leucocyte antigen variant HLADQA1*05 (rs2097432) are at risk of developing antibodies against infliximab and adalimumab with reduced tumor necrosis factor (TNF) antagonist persistence. The impact of proactive therapeutic drug monitoring (PTDM) on this association has been barely assessed.

Methods
We conducted a retrospective single-center cohort study including patients with inflammatory bowel disease starting anti-TNF therapy between January 2017 and March 2021. Proactive therapeutic drug monitoring was defined as periodic drug level measurement (≥2 determinations during the first year of treatment and ≥1/annual determination during the following years), regardless of clinical condition, followed by dose optimization. Variables associated with treatment persistence were assessed with multivariable Cox regression analysis.

Results
A total of 112 patients were included, 52 (46.4%) HLA-DQA1*05 carriers, with a median follow-up of 73.9 (interquartile range, 35.4-133.1) weeks. Combination therapy with thiopurines was more frequent among HLA-DQA1*05 noncarriers (28 [46.7%] vs 12 [23.1%]; P = .01). Clinical remission rates at week 14 (77.9% vs 73.9%; P = .69) and 56 (73.2% vs 68.4%; P = .64) were similar between HLA-DQA1*05 noncarriers and carriers. Drug persistence was higher among HLA-DQA1*05 carriers (hazard ratio [HR], 0.32; 95% confidence interval, 0.14-0.71; P = .01). Multivariable Cox regression analysis identified systemic steroids at anti-TNF initiation (HR, 4; 95% confidence interval, 1.7-9.7) as a risk factor and HLA-DQA1*05 carriers (HR, 0.31; 95% confidence interval, 0.12–0.81) as a protective factor of treatment cessation.

Conclusion
In adult patients with PTDM, a positive HLA-DQA1*05 genotype does not associate a higher risk of treatment cessation nor worse clinical outcomes.
Estimated Glomerular Filtration Rate and the Risk of Inflammatory Bowel Disease in Adults: A Swedish Population-Based Study
Authors: Yang Yuanhang , Ludvigsson Jonas F , Olén Ola , Sjölander Arvid , Carrero Juan J 
Published: January 2023

Abstract

Background
Kidney complications are common in patients with long-standing inflammatory bowel disease (IBD). Whether kidney complications, defined as low estimated glomerular filtration rate (eGFR), may predispose to later IBD is unknown.

Methods
We analyzed the association between eGFR and the risk of being subsequently diagnosed with IBD among 1 612 160 adults from Stockholm. The exposure was categories of eGFR, with 90 to 104 mL/min/1.73 m2 as the reference. Cox regression models were used to investigate the association between eGFR, IBD, and IBD subtypes. Subgroup analyses included age strata, sex, education, and comorbidities. To explore the possibility of detection bias or reverse causation, we estimated IBD hazard ratios (HRs) after excluding cases and individuals censored during early years of follow-up.

Results
During a median of 9 years of follow-up, we detected 9663 cases of IBD (3299 Crohn’s disease, 5072 ulcerative colitis, 1292 IBD unclassified). Lower eGFR levels were associated with higher IBD risk (for eGFR 30-59 mL/min/1.73 m2: adjusted HR, 1.15; 95% confidence interval [CI], 1.01-1.33; and for eGFR &lt;30 mL/min/1.73 m2: adjusted HR, 1.65; 95% CI, 1.16-2.37). This association was stronger in magnitude for Crohn’s disease (for eGFR 30-59 mL/min/1.73 m2: HR, 1.33, 95% CI, 1.04-1.72; and for eGFR &lt;30 mL/min/1.73 m2: HR, 2.25; 95% CI, 1.26-3.99). Results were consistent across strata of age, comorbidities, and attained education but suggested the association between eGFR and IBD to be stronger in women (P for interaction &lt;.05). Results attenuated but were robust to exclusion of early IBD cases.

Conclusions
We observed an association between reduced eGFR and the risk of developing IBD, which was stronger in magnitude for Crohn’s disease.