bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond society's desire for a slowed‐down temporal experience: Toward a nomological network of individuals' need‐for deceleration
Authors: Sager Anna‐Lena , Timm Jule , Hoffmann Stefan , Orth Ulrich R. 
Published: July 2023

AbstractThis study expands on past deceleration and slow consumption research by introducing and validating a measure of need‐for‐deceleration, an individual's motivational ability to engage in activities aimed at slowing down the perceived fast passage of time. Following initial scale development, two studies establish construct validity by placing need‐for‐deceleration into a nomological network. Results indicate that the measure correlated with, but was distinct from, variables involving negative affective states, such as state anxiety and neuroticism. Need‐for‐deceleration scores were not related to materialism, but negatively correlated with self‐efficacy, life satisfaction, work‐life balance, and conscientiousness. Correlations were positive with need‐for‐uniqueness, future time orientation, and susceptibility to normative influence. Need‐for‐deceleration was also associated with regulatory focus (positively with prevention, and negatively with promotion focus). To explore criterion validity, a third study establishes associations between need‐for‐deceleration and consumer lifestyle variables. Developing and validating the scale can help researching and managing products relating to the consumption of time, wellness, mindfulness, and simplicity.
The mirrored cationic peptide as miRNA vehicle for efficient lung cancer therapy
Authors: Xu Wenyan , Du Lingran , Yu Lina , Cen Huiyu , Lin Fangyu , Wang Siran , Ruan Zhixiong , Lin Zhongxiao , Zhang Xin , Zhou Na , Chang Jishuo , Yu Xiyong , Zhang Lingmin , Liang Lu 
Published: July 2023

AbstractGene therapy has emerged as a potential approach for lung cancer therapy. However, the application of gene therapy is still limited by their properties, such as low specificity to the cancer cells, negatively charged groups, short systemic circulation time, and rapid degradation by nucleases. The progression of lung adenocarcinoma (LUAD) can be promoted through the methylation process of miR‐148a‐3p promoter, as confirmed by our previous research. In the current study, we are the first to design a mirrored Arg‐Gly‐Asp (RGD)‐modified cationic peptide (RD24) as a microRNA (miRNA) vehicle, which enabled to pack the miRNA (miR‐148a‐3p) efficiently and generate RD24/miR‐148a‐3p nanoparticles (RPRIN) by self‐assembling. RPRIN exhibited a high transfection efficiency in lung cancer cells via the conjugation between RGD and integrins on the surface of lung cancer cells. Furthermore, RD24 showed matrix metallopeptidase 2 (MMP2) responsiveness, which improved lung cancer cell inhibition induced by the miRNA intracellularly. In addition, RPRIN exhibits several advantages, such as prolonged circulation duration, reduced toxicity, and immune escape. Experiments conducted both in vitro and in vivo revealed that RPRIN effectively suppressed the growth and progression of lung cancer. Thus, the mirrored RGD‐modified cationic peptide showed great potential in transducing miRNA for lung cancer therapy.
Safety and Efficacy of Long‐Term Deutetrabenazine Use in Children and Adolescents with Tics Associated with Tourette Syndrome: An Open‐Label Extension Study
Authors: Jankovic Joseph , Coffey Barbara , Claassen Daniel O. , Jimenez‐Shahed Joohi , Gertz Barry J. , Garofalo Elizabeth A. , Stamler David A. , Wieman Maria , Savola Juha‐Matti , Harary Eran , Alexander Jessica , Barkay Hadas , Gordon Mark Forrest 
Published: July 2023

ABSTRACTBackgroundTourette syndrome (TS) is a neurodevelopmental disorder characterized by motor and phonic tics.ObjectiveTo assess the safety and efficacy of deutetrabenazine (Teva Neuroscience, Inc, Parsippany, NJ), a vesicular monoamine transporter 2 inhibitor, in children and adolescents with TS.MethodsAlternatives for Reducing Tics in TS (ARTISTS) open‐label extension (OLE) (NCT03567291) was a 54‐week, global, phase 3, open‐label extension study of deutetrabenazine (6–48 mg daily) conducted May 28, 2018 to April 3, 2020 with a 2‐week randomized withdrawal period. Participants (6–16 years of age) had TS and active tics causing distress or impairment. Safety (primary outcome) was assessed by treatment‐emergent adverse events (TEAEs) and clinical laboratory testing. Efficacy was measured by the Yale Global Tic Severity Scale‐Total Tic Score (YGTSS‐TTS).ResultsThe intent‐to‐treat population (228 participants; mean age, 12.0 years; 79.8% male; 86.4% white) had a median (range) duration of exposure of 28.4 (0.3–52.9) weeks. Of 227 participants in the safety analysis, 161 (70.9%) reported ≥1 TEAE (exposure‐adjusted incidence rate, 2.77/patient‐year), of which 95 (41.9%) were treatment related. The most frequently reported TEAEs were headaches, somnolence, nasopharyngitis, weight increases, and anxiety. No additional safety signals were observed. Worsening of YGTSS‐TTS after the 2‐week randomized withdrawal was not statistically significant (least squares mean difference, −0.4; P = 0.78). Several exploratory measures showed sustained improvement throughout the treatment periods.ConclusionsIn this long‐term, open‐label trial, deutetrabenazine was well tolerated with low frequency of TEAEs. There was no significant difference in tics between treatment arms during the 2‐week randomized withdrawal period, however, descriptive statistics and comparison with baseline showed a numeric improvement in tics, quality of life, and other measures.
Parallel dual‐cavity fiber‐optic F‐P salinity sensor based on hollow core fiber and ceramic ferrule
Authors: Li Yitong , Sun Lin , Yang Yuqiang , Mu Xiaoguang , Gao Jiale , Li Yuting , Zhang Yuying 
Published: July 2023

AbstractA parallel dual‐cavity fiber‐optic Fabry‐Perot (F‐P) salinity sensor based on hollow core fiber and a ceramic ferrule is proposed. The sensor is comprised of a F‐P reference cavity and a F‐P sensing cavity in parallel. The reference cavity is a closed cavity that is fusion spliced with a segment of single‐mode optical fiber (SMF) and a small piece of silica tube (ST). The sensing cavity is an open liquid cavity that is connected by a ferrule after inserting two single‐mode fibers into a ceramic core, facilitating the replacement of salt water. Variations in the salinity of salt water will affect the change in refractive index of optical path, and then change the output spectral structure. By precisely controlling the length of two cavities, the free spectral range (FSR) of the sensing cavity is approximately equal to the FSR of the reference cavity, resulting in the generation of the Vernier effect, which improves the sensitivity of the sensor to salinity greatly. From the experimental results, it can be seen that the sensor sensitivity to salinity reaches −0.78 nm/‰ (−3809.68  nm/RIU) in the salinity range from 35‰ to 20‰ at room temperature of 25°C, which is 10.8 times higher than the sensitivity of a single sensing cavity. The enhancement factor is generally consistent with theoretical analysis results.
Automated nuclear magnetic resonance fingerprinting of mixtures
Authors: Specht Thomas , Arweiler Justus , Stüber Johannes , Münnemann Kerstin , Hasse Hans , Jirasek Fabian 
Published: July 2023

AbstractNuclear magnetic resonance (NMR) spectroscopy is a powerful tool for qualitative and quantitative analysis. However, for complex mixtures, determining the speciation from NMR spectra can be tedious and sometimes even unfeasible. On the other hand, identifying and quantifying structural groups in a mixture from NMR spectra is much easier than doing the same for components. We call this group‐based approach “NMR fingerprinting.” In this work, we show that NMR fingerprinting can even be performed in an automated way, without expert knowledge, based only on standard NMR spectra, namely, 13C, 1H, and 13C DEPT NMR spectra. Our approach is based on the machine‐learning method of support vector classification (SVC), which was trained here on thousands of labeled pure‐component NMR spectra from open‐source data banks. We demonstrate the applicability of the automated NMR fingerprinting using test mixtures, of which spectra were taken using a simple benchtop NMR spectrometer. The results from the NMR fingerprinting agree remarkably well with the ground truth, which was known from the gravimetric preparation of the samples. To facilitate the application of the method, we provide an interactive website (https://nmr-fingerprinting.de), where spectral information can be uploaded and which returns the NMR fingerprint. The NMR fingerprinting can be used in many ways, for example, for process monitoring or thermodynamic modeling using group‐contribution methods—or simply as a first step in species analysis.
Gastric microbiota and its role in gastric carcinogenesis
Authors: Jiang Xiaowen , Peng Lei , Zhang Li , Li Zhexuan , Zhou Tong , Zhang Jingying , Li Wenqing , You Weicheng , Zhang Yang , Pan Kaifeng 
Published: August 2023

AbstractGastric cancer (GC) is one of the most common malignancies globally, the occurrence of which undergoes a multistage chronic evolutionary process. It is a great public health issue to deeply understand the mechanisms of GC development and factors affecting the evolution of gastric lesions. Helicobacter pylori infection has been identified as one of the main factors for gastric carcinogenesis and microbial dysbiosis. With the advances in molecular biology techniques, other gastric microbes besides H. pylori have been observed to play an essential role in the development of GC. Previous animal model studies suggested that specific and critical microbes in the stomach can accelerate the malignant transformation of gastric mucosa and the progression of gastric lesions to GC. Recently, the composition of human gastric microbiota has been investigated from stages of precancerous lesions to GC, including characteristics of gastric microbiota diversity, lesion‐associated differential microbes, predicted microbiota‐related functions, microbiota interactions, and microbial mechanisms in gastric carcinogenesis. In this review, we provide an overview of the gastric microbiota, summarize current studies exploring the roles of microbiota in gastric carcinogenesis, and illustrate the significance and prospects of integrative multiomics analysis combined with the microbiome in gastric carcinogenesis.
Muscle MRI in periodic paralysis shows myopathy is common and correlates with intramuscular fat accumulation
Authors: Vivekanandam Vinojini , Suetterlin Karen , Matthews Emma , Thornton John , Jayaseelan Dipa , Shah Sachit , Morrow Jasper M. , Yousry Tarek , Hanna Michael G. 
Published: July 2023

AbstractIntroduction/AimsThe periodic paralyses are muscle channelopathies: hypokalemic periodic paralysis (CACNA1S and SCN4A variants), hyperkalemic periodic paralysis (SCN4A variants), and Andersen‐Tawil syndrome (KCNJ2). Both episodic weakness and disabling fixed weakness can occur. Little literature exists on magnetic resonance imaging (MRI) in muscle channelopathies. We undertake muscle MRI across all subsets of periodic paralysis and correlate with clinical features.MethodsA total of 45 participants and eight healthy controls were enrolled and underwent T1‐weighted and short‐tau‐inversion‐recovery (STIR) MRI imaging of leg muscles. Muscles were scored using the modified Mercuri Scale.ResultsA total of 17 patients had CACNA1S variants, 16 SCN4A, and 12 KCNJ2. Thirty‐one (69%) had weakness, and 9 (20%) required a gait‐aid/wheelchair. A total of 78% of patients had intramuscular fat accumulation on MRI. Patients with SCN4A variants were most severely affected. In SCN4A, the anterior thigh and posterior calf were more affected, in contrast to the posterior thigh and posterior calf in KCNJ2. We identified a pattern of peri‐tendinous STIR hyperintensity in nine patients. There were moderate correlations between Mercuri, STIR scores, and age. Intramuscular fat accumulation was seen in seven patients with no fixed weakness.DiscussionWe demonstrate a significant burden of disease in patients with periodic paralyses. MRI intramuscular fat accumulation may be helpful in detecting early muscle involvement, particularly in those without fixed weakness. Longitudinal studies are needed to assess the role of muscle MRI in quantifying disease progression over time and as a potential biomarker in clinical trials.
Consensus on the items for early identification of unmet psychosocial needs of siblings of children with cancer and blood disease: A modified Delphi method
Authors: Kaneko Taro , Niinomi Kazuteru , Nonoyama Tomo , Makishita Akane , Asano Midori 
Published: July 2023

AbstractAimTo reach a consensus on question items for early identification of unmet psychosocial needs of school‐aged siblings of children with cancer and blood disease.DesignModified Delphi method.MethodsTwenty‐three studies were reviewed to extract question items, which were classified into seven categories. A total of 39 question items were selected for this study. The selected question items were carefully considered using the modified Delphi method. The participants were 28 medical staff from a childhood cancer hub hospital and 20 sibling support group staff members. The first round consisted of a questionnaire (n = 48); the second, a focus group interview (n = 8) and the third, another questionnaire (n = 8). The first and third rounds used a 5‐point Likert scale. This survey was conducted from July to October 2021.ResultsA total of 38, 26, and 24 question items were included in the first, second, and third rounds respectively. A total of 24 question items were extracted using the modified Delphi method to identify siblings' unmet psychosocial needs: relationship with family members, 3; daily life issues, 4; stress, 6; emotions, 3; information, 3; relationships with medical staff, 1 and social and medical resources, 4. Seven categories and 24 question items were confirmed as items for identifying the unmet psychosocial needs of school‐aged siblings of children with cancer and blood disease.
Pattern of lifestyle behaviors and associated risk of being bullied at schools: A latent class analysis of 25,379 adolescents in Jiangsu Province of China
Authors: Huang Feng , Wang Yan , Yang Jie , Zhang Fengyun , Wang Xin , Xiang Yao , Yang Wenyi , Zhou Yonglin , Fan Lijun , Du Wei 
Published: August 2023

AbstractSchool bullying is a worldwide problem. Although previous studies examined the association between different lifestyle behaviors and bullying victimization, the complex co‐occurrence of these behaviors was not identified, and their association with the risk of being bullied remains unclear. We aimed to identify the behavioral patterns of adolescents and to explore their association with bullying victimization. This cross‐sectional study employed data from the “Surveillance for Common Diseases and Health Risk Factors among Students” project implemented in Jiangsu Province of China in 2019, and a total of 25,379 school‐enrolled students were included. We used a latent class analysis to identify behavioral patterns and a regression mixture model to explore various demographic characteristics, such as age, sex, and family structure in relation to bullying victimization across different patterns. We considered respondents having targeted behaviors, including smoking, alcohol consumption, illicit drug use, sugar consumption, no fruit consumption, low physical activity, electronic media use, and insufficient sleep. Four behavioral patterns were identified, including the “adolescents without apparent targeted behaviors” (19.65%), “substance and electronic media users” (12.76%), “typical electronic media users” (54.49%), and “typical substance users” (8.10%). The risk of being bullied was the highest in the “substance and electronic media users” (probability: 0.33), tripled that in “adolescents without apparent targeted behaviors” (odds ratio: 3.60, 95% confidence interval: 3.01–4.30). Risk of being bullied was reduced for those "substance and electronic media users" living with a nuclear family. Behavioral patterns and their association with being bullied differ between groups of school‐aged adolescents. To better inform decision‐making based on the current real‐world findings, the implementation of bullying prevention programs could target specific behavioral patterns.
Construction of a copper hydroxystannate functionalized graphene oxide for rigid polyvinyl chloride foam toward improved fire safety
Authors: Huang Zhenyu , Wang Zhengzhou 
Published: July 2023

AbstractA copper hydroxystannate (CHS) functionalized graphene oxide (GO) (CHS@GO) was feasibly prepared through an in‐situ method, and well characterized by TEM, XRD, FTIR and XPS. Rigid poly vinyl chloride (RPVC) foams containing CHS@GO were prepared by utilizing methyl hexahydrophthalic anhydride and isocyanate as coupling agents, azodiisobutyronitrile and azodicarbonamide as blowing agents. The fire safety, mechanical properties and thermal decomposition behavior of the RPVC foams were studied. The RPVC foam containing 2 wt% CHS@GO (RPVC/2CHS@GO) achieved a limiting oxygen index (LOI) of 35.5% and a V0 rating in the UL‐94 tests. The cone calorimetric tests (CCT) results demonstrated the peak heat release rate (pHRR) and total heat release (THR) of RPVC/2CHS@GO were reduced by 40.6% and 36.8%, respectively, compared with those of pure RPVC foam (pure RPVC). The compressive strength and flexural strength of RPVC/2CHS@GO were increased by 47.3% and 34.6%, respectively, in contrast with those of Pure RPVC. The thermogravimetry results showed that CHS@GO endowed the RPVC foams with improved char residue.
Dynamic mechanical analysis for assessment of carbon fillers in glass fiber epoxy composites
Authors: Aradhya Rashmi , Sundara Rajan J. 
Published: July 2023

AbstractThe effect of incorporation of micron sized aluminum trihydrate, multi‐walled carbon nanotubes, and graphene nano platelets into glass fiber reinforced epoxy matrix is investigated using dynamic mechanical analysis. The objective of the investigation was to develop polymer central core of high temperature low sag transmission conductor. The effect of individual and hybrid carbon fillers on the viscoelastic properties of the epoxy composites is investigated and discussed. The storage modulus of the glass reinforced epoxy increases by 20% at room temperature due to incorporation of carbon nanofillers. In glass transition region, the increase is higher between 40% and 60% and it varies up to 90% in the rubbery region. Key attributes of carbon filler addition are limited enhancement of storage modulus at room temperature, higher enhancement over glassy, glass transition, and rubbery regions. The carbon fillers extend the temperature range of the glassy region. The cross‐link density, filler efficiency, and degree of entanglement of fibers are estimated to understand the implications of the carbon fillers on the viscoelastic properties. The loss modulus peak of glass epoxy composite increases from 2800 to 3900 MPa with carbon fillers and the increase in glass transition temperature is 47°C. Incorporation of carbon fillers leads to increase of damping factor peak from 0.2 to 0.28. Cole–Cole plots have established the inherent heterogeneity of epoxy systems due to the presence of carbon fillers. Prediction models for storage modulus and damping factor have been proposed to highlight the influence of geometry and size of carbon filler.
A comprehensive experimental study of enhanced solid particle erosive resistance on the inner/outer surface of graphene nanoplatelets modified basalt/epoxy composite pipe
Authors: Sepetcioglu Harun , Demet Seyit Mehmet , Bagci Mehmet 
Published: August 2023

AbstractBasalt fiber reinforced polymer (BFRP) composite pipe is an excellent alternative to glass and carbon fiber reinforced composite pipes in industry and promising in high recycling for polymer composite used in aerospace, marine, and automotive. To enhance the solid particle erosion (SPE) properties of filament‐wound BFRP composite pipe while preserving its mechanical properties, reinforced BFRP composite pipes were prepared to employ non‐functionalized graphene nanoplatelets (GnPs) at a reinforcement concentration of 0.25 wt.% and ultrasonication mixing technique. The SPE behavior of GnPs reinforced and non‐reinforced BFRP composite pipes were characterized by axial and radial positioning of the inner and outer surfaces of the pipes. In each case, the erosion rates of these composite pipes were evaluated at five impingement angles (30°, 45°, 60°, 75°, and 90°) and an impact velocity of 34 m/s. The erosion response of both BFRP composite pipes' outer surfaces showed a semi‐ductile in the axial positioning, with a maximum erosion rate at a 60° impingement angle. However, these composite pipes' inner surfaces in the same positioning presented a maximum erosion rate at a 45° impingement angle. Besides, it is explored that the GnPs contribute to an improvement of approximately 10%–55% in erosive wear resistance of the non‐reinforced BFRP composite pipes. The damage analysis of eroded surfaces was examined through scanning electron microscopy (SEM), and the GnPs effect upon composite pipes' erosion micromechanisms was presented and discussed in detail.Highlights
GnPs increased the BFRP composite pipe's erosion resistance.
Erosion rate on the inner surface increases due to particle accumulation.
GnPs improved erosion behavior via solid lubrication and mechanical properties.
Effect of printing path on compressive properties of 3D printed continuous fiber composite negative Poisson's ratio structure
Authors: Liu Baosheng , Lou Ruishen , Liu Xin , Yao Yunxiang , Li Huimin 
Published: July 2023

AbstractIn this work, continuous fiber reinforced thermoplastic negative Poisson's ratio structures (CFNPRSs) with rotating squares are fabricated by 3D printing based on a symmetrical orthogonal and one‐stoke path planning method. The influences of the printing path on the Poisson's ratio, elastic modulus and energy absorption of the structures under compression are systematically researched. The distribution of continuous fiber at the hinge has a great influence on the compression behavior of the structures. As the number of cross laps of continuous fibers at the hinge increases, the negative Poisson's ratio effect decreases while the elastic modulus and energy absorption increase. The printed CFNPRSs with no cross lap have the most obvious negative Poisson's ratio effect, with an average Poisson's ratio of −0.61. A comparative study on Poisson's ratio of the 3D printed polylactic acid negative Poisson's ratio structures (PANPRSs) is carried out, and the results show that the PANPRSs cannot achieve the negative Poisson's ratio effect because the insufficient stiffness of the printed rotation units violates the rigid assumption in theoretical model. Furthermore, the printed CFNPRSs with a lower relative density of 0.18 has an even better negative Poisson's ratio effect than the existing fiber‐reinforced auxetic structures fabricated by 3D printing. This work can provide a significant reference for the preparation of lightweight functional structures using 3D printing.Highlights
The CFNPRSs with rotating squares are prepared by 3D printing technique.
The path planning of the fiber at the hinge affects the properties of CFNPRSs.
The negative Poisson's ratio of CFNPRSs is more obvious than that of PANPRSs.
The relative density and Poisson's ratio of CFNPRSs have obvious advantages.