bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daurisoline suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting MEK1/2 kinase
Authors: Wang Donghao , Zhang Weizhe , Zhang Xiaofan , Li Mingzhu , Wu Qiong , Li Xin , Zhao Lili , Yuan Qiang , Yu Yin , Lu Jing , Zhao Jimin , Dong Zigang , Liu Kangdong , Jiang Yanan 
Published: January 2023

AbstractEsophageal squamous cell carcinoma (ESCC) accounts for 90% of esophageal cancers and has a high mortality rate worldwide. The 5‐year survival rate of ESCC patients in developing countries is <20%. Hence, there is an urgent need for developing new and effective treatments that are based on newly‐discovered emerging molecules and pathways to prevent ESCC occurrence and recurrence. We investigated the effects of Daurisoline, a bis‐benzylisoquinoline alkaloid extracted from the rhizome of menisperum dauricum, on ESCC cell proliferation and elucidated the molecular mechanisms underlying its functions. To explore the effects of Daurisoline on ESCC growth in vitro and in vivo, cell proliferation assays and anchorage‐independent growth assays were performed and a patient‐derived xenograft (PDX) model was established. Subsequently, phosphoproteomics, molecular docking analysis, pull down assays, mutation experiments and in vitro kinase assay were performed to explore the mechanism of Daurisoline's function on ESCC. Daurisoline inhibited ESCC proliferation in vitro and reduced ESCC PDX exnograft growth in vivo by reducing ERK1/2 phosphorylation. Furthermore, it directly bound to MEK1 (at Asn78 and Lys97) and MEK2 (at Asp194 and Asp212) kinases to inactivate the ERK1/2 signaling pathway. Our results suggest that Daurisoline is a dual inhibitor of MEK1 and MEK2 and suppresses ESCC growth both in vitro and in vivo by inactivating the ERK1/2 signaling pathway. This is first report on the use of MEK inhibitor for ESCC and highlights its potential applications for ESCC treatment and prevention.
Patients with Cognitive Impairment in Parkinson's Disease Benefit from Deep Brain Stimulation: A Case‐Control Study
Authors: Block Cady K. , Patel Margi , Risk Benjamin B. , Staikova Ekaterina , Loring David , Esper Christine D. , Scorr Laura , Higginbotham Lenora , Aia Pratibha , DeLong Mahlon R. , Wichmann Thomas , Factor Stewart A. , Au Yong Nicholas , Willie Jon T. , Boulis Nicholas M. , Gross Robert E. , Buetefisch Cathrin , Miocinovic Svjetlana 
Published: January 2023

AbstractBackgroundDeep brain stimulation (DBS) for Parkinson's disease (PD) is generally contraindicated in persons with dementia but it is frequently performed in people with mild cognitive impairment or normal cognition, and current clinical guidelines are primarily based on these cohorts.ObjectivesTo determine if moderately cognitive impaired individuals including those with mild dementia could meaningfully benefit from DBS in terms of motor and non‐motor outcomes.MethodsIn this retrospective case‐control study, we identified a cohort of 40 patients with PD who exhibited moderate (two or more standard deviations below normative scores) cognitive impairment (CI) during presurgical workup and compared their 1‐year clinical outcomes to a cohort of 40 matched patients with normal cognition (NC). The surgery targeted subthalamus, pallidus or motor thalamus, in a unilateral, bilateral or staged approach.ResultsAt preoperative baseline, the CI cohort had higher Unified Parkinson's Disease Rating Scale (UPDRS) subscores, but similar levodopa responsiveness compared to the NC cohort. The NC and CI cohorts demonstrated comparable degrees of postoperative improvement in the OFF‐medication motor scores, motor fluctuations, and medication reduction. There was no difference in adverse event rates between the two cohorts. Outcomes in the CI cohort did not depend on the target, surgical staging, or impaired cognitive domain.ConclusionsModerately cognitively impaired patients with PD can experience meaningful motor benefit and medication reduction with DBS.
Development and Psychometric Properties of a New Brief, Yet Comprehensive, Behavioral Questionnaire for Huntington's Disease
Authors: Hughes Shelby , Aboufadel Sameer , Smirnova Anna , Snell Chase , Churchill Emma , Hall Andrew , Malcarne Vanessa , Gilbert Paul E. , Corey‐Bloom Jody 
Published: January 2023

ABSTRACTBackgroundIndividuals with Huntington's disease (HD) experience motoric, cognitive, and psychiatric dysfunction. These difficulties can cause maladaptive behaviors that can be very distressing to family and caregivers. Capturing these behaviors in clinical and research settings is crucial.ObjectivesTo develop and evaluate the psychometric properties of an instrument that is brief, yet comprehensive, in assessing a broad range of behaviors in HD.MethodsA pool of 30 items encompassing common behaviors in HD was generated. Items were scored on a 4‐point Likert scale ranging from completely disagree to completely agree, with higher scores indicating greater dysfunction. The self‐report measure was piloted on a small sample of individuals with HD. Reliability (test–retest, internal consistency) and validity (convergent, discriminant, criterion) were evaluated.ResultsThe HD–Behavioral Questionnaire (HD‐BQ) demonstrated evidence for reliability with a test–retest correlation coefficient ofr = 0.81 and an internal consistency of 0.96. Validity was established with evidence for good convergent, divergent, and criterion validity. A receiver operating characteristic curve showed that the HD‐BQ outperformed a similar commonly used measure in diagnostic capability of behaviors in HD.ConclusionsThe HD‐BQ, a patient self‐report measure, was created to more fully explore behavioral issues that people with HD experience in response to limitations of commonly used instruments in the field. Psychometric evidence supports that the HD‐BQ is a valid and reliable instrument for the brief, yet comprehensive, assessment of problematic behaviors in HD.
Dual effects of corporate philanthropy on firm value: Evidence from China
Authors: Zhang Shuxia , Kong Deyue , Xu Liping , Xu Ruiyu 
Published: January 2023

AbstractThis study demonstrates that corporate philanthropy (CP) has dual attributes by theorizing and testing the existence of rational CP and irrational CP and their opposite effects on firm value. The empirical results show that rational CP has a positive effect on firm value, while irrational CP has a negative effect on firm value. Further analysis shows that the negative effect of irrational CP on firm value is stronger in firms with corporate foundations and in state‐owned firms. The findings can coordinate the theoretical contradiction and empirical divergence between the efficiency view and the agency view existing in the current research.
Omental vascularized lymph node transplant for the treatment of breast lymphedema: A case report
Authors: Hirsch Thomas I. , Friedman Rosie , Granoff Melisa , Tsai Leo L. , Critchlow Jonathan F. , Sharma Ranjna , Singhal Dhruv 
Published: January 2023

AbstractBreast lymphedema is a type of breast cancer related lymphedema that leads to significant discomfort and negative impact on body image. Conservative therapy and lymphovenous bypass have been previously described as possible treatment methods for breast lymphedema, however, a unified approach to treatment is lacking. The current report describes a case of breast lymphedema successfully treated with vascularized lymph node transfer (VLNT) after failed attempt at management with conservative therapy. The patient is a 48‐year‐old female with right‐sided breast cancer who underwent breast conservation therapy in 2015 and subsequently developed pain and swelling of the right breast. The diagnosis of breast lymphedema was supported by clinical evaluation as well as MRI, lymphoscintigraphy, and lymphography. In consultation with a breast surgeon, breast lymphedema was determined not to be an indication for mastectomy. The patient was offered and underwent an omental VLNT to the right breast. A 20 cm segment of omentum with associated gastroepiploic vessels and lymph nodes was harvested, transferred to the right axilla and gastroepiploic vessels were anastomosed to the recipient thoracodorsal vessels. The patient tolerated the procedure well and there were no complications. Additional donor sites were considered, such as the groin and submental regions, but an omental flap was favored in this case because of the lower risk of donor site lymphedema. In the years following, the patient reported significant improvement in symptoms as well as objective reduction of edema on MRI. We propose the consideration of VLNT for breast lymphedema refractory to other methods of management.
Analysis and design of trapezoidal shape CSRR rectangular patch antenna for wireless communications
Authors: Sri P. Amala Vijaya , Ketavath Kumar Naik 
Published: January 2023

AbstractA monopole rectangular shape patch antenna (RSPA) with trapezoidal shape complementary split ring resonator (CSRR) is designed for wireless communication application is presented in this paper. The trapezoidal shape CSRR is considered to obtain circular polarization and rectangular slit is considered to operate antenna for triple frequencies at 1.88, 4.17, and 6.73 GHz, respectively. The axial ratio of 1.25, 1.05, 1.28 dB is observed and a maximum gain of 6.29 dBi at 1.88 GHz frequency is produced. The RSPA model is designed for mobile and fixed satellite application.
Deterioration of mitochondrial biogenesis and degradation in the endometrium is a cause of subfertility in cows
Authors: Matsuyama Shuichi , Nakamura Sho , Minabe Shiori , Sakatani Miki , Takenouchi Naoki , Sasaki Takuya , Inoue Yuki , Iwata Hisataka , Kimura Koji 
Published: January 2023

AbstractTo investigate possible causes of reproductive failure, we conducted global endometrial gene expression analyses in fertile and subfertile cows. Ingenuity pathway analysis showed that RICTOR and SIRT3 are significant upstream regulators for highly expressed genes in fertile cows, and are predicted to be activated upstream regulators of normal mitochondrial respiration. Canonical pathway analysis revealed that these highly expressed genes are involved in the activation of mitochondrial oxidative phosphorylation. Therefore, in subfertile cows, the inactivation of RICTOR and SIRT3 may correlate with decreased capacity of mitochondrial respiration. Furthermore, the expression levels of most mitochondrial DNA genes and nuclear genes encoding mitochondrial proteins were higher in subfertile cows. The mitochondrial DNA copy number was significantly higher in the endometrium of subfertile cows, whereas the ATP content did not differ between fertile and subfertile cows. Quantitative reverse transcription‐PCR analysis demonstrated that the expression of PGC1a, TFAM, MFN1, FIS1, and BCL2L13 were significantly lower in subfertile cows. In addition, transmission electron microscopy images showed mitochondrial swelling in the endometrial cells of the subfertile cow. These results suggest that poor‐quality mitochondria accumulate in the endometrium owing to a reduced capacity for mitochondrial biogenesis, fusion, fission, and degradation in subfertile cows, and may contribute to infertility.
Reasons for non‐participation in a psychological intervention trial for distress in colorectal cancer survivors
Authors: Custers José A. E. , Döking Sarah , van der Hoeven Yvonne C. W. , Thewes Belinda , Dekker Joost , Braamse Annemarie M. J. , Prins Judith B. 
Published: January 2023

AbstractObjectiveHigh psychological distress is reported by one third of colorectal cancer survivors (CRCS). However, intervention studies for CRCS have reported low participation rates. In this study, reasons for non‐participation and low uptake in a psychological intervention trial were investigated.MethodsCRCS were recruited for a randomized clinical trial on the efficacy of blended cognitive behavior therapy for psychological distress via databases, follow‐up consultations, advertisements and an ongoing population‐based study. The recruitment flow and reasons for non‐participation were analyzed for patients recruited between 2016 and 2020. Subgroups were compared based on demographic, clinical and screening data. High distress as study entry criterion was measured with the Distress Thermometer (DT ≥ 5) and the problem list (PL).ResultsFrom all recruitment methods together, 1326 CRCS responded to the invitation letter of whom 510 (38%) were interested in receiving a screening questionnaire. Interested CRCS were significantly younger than non‐interested CRCS (p < 0.001). Most non‐interested CRCS reported having no complaints. Of interested CRCS, 448 (88%) completed screening with the DT of which 213 (48%) CRCS scored above the DT cutoff for high distress. The majority expressed no need for help resulting in 84 (4% of eligible) CRCS included in the trial. Younger age, shorter time since diagnosis and more problems on the PL were positively related to participation.ConclusionsIn this study a low participation rate was found. However, patients with high distress and most in need for help were included in the trial. For future research it is recommended to perform pilot‐ and feasibility studies to optimize recruitment.
Model‐based meta‐analysis of non‐small cell lung cancer with standard of care PD‐1 inhibitors and chemotherapy for early development decision making
Authors: Turner David C. , Wada Russ , Zhou Helen , Wang Xiaowei , de Greef Rik , Valiathan Chandni , Zhang Lindsey , Zhang Nancy , Kuchimanchi Mita , Chen Tai‐Tsang , Ballas Marc , Visser Sandra A. G. 
Published: January 2023

AbstractSingle‐arm cohorts/trials are often used in early phase oncology programs to support preliminary clinical activity assessments for investigational products, administered alone or in combination with standard of care (SOC) agents. Benchmarking clinical activity of those combinations against other treatments, including SOC, requires indirect comparisons against external trials, which presents challenges including cross‐study differences in trial populations/other factors. To facilitate such nonrandomized comparisons, we developed a comprehensive model‐based meta‐analysis (MBMA) framework to quantitatively adjust for factors related to efficacy in metastatic non‐small cell lung cancer (mNSCLC). Data were derived from 15 published studies assessing key programmed cell death protein‐1 (PD‐1) inhibitors pembrolizumab (n = 8) and nivolumab (n = 7), representing current SOC in mNSCLC. In the first stage, a mixed‐effects logistic regression model for overall response rate (ORR) was developed accounting for effects of various population covariates on ORR. The ORR model results indicated an odds ratio (OR) of 1.02 for squamous versus non‐squamous histology and OR of 1.20 for PD‐ligand 1 tumor proportion score (TPS) per every 10% increase of TPS level. Next, a nonparametric mixed‐effects model for overall survival (OS) was developed with ORR/other clinical covariates as input. Subsequently, MBMA simulations of relevant hypothetical scenarios involving single‐arm trial design predicted OS hazard ratios as a function of ORR with matched patient characteristics. Findings from this MBMA and derived parameter estimates can be generally applied by the reader as a framework for interpreting efficacy data from early phase trials to support ORR‐based go/no‐go decisions and futility rules, illustrated through examples in this report.
Research with and by children: A systematic literature review
Authors: Bakhtiar Aishah , Lang Megan , Shelley Becky , West Melody 
Published: January 2023

AbstractThe choice to conduct research projects done with or by children is a political one. It reflects a standpoint that appreciates children's position as agentic beings and acknowledges their expertise. There are complex questions for academics and practitioners engaged in such research projects. This paper reports on a systematic review of peer‐reviewed research relating to children as researchers. The scope of the analysis is limited to children aged 15 and under, who were involved in at least one component of a research project. Twenty‐five published articles are included, and they demonstrate varied methods of engagement. The theoretical perspective the studies adopted may focus on one of three: (a) child‐led research, (b) children as co‐researchers, or (c) youth participatory action research. Not all studies included child researchers in all aspects of a research project, with participation influenced by the adopted theoretical perspective as well as reported barriers and challenges. This review presents the results of a systematic examination of the included papers, including approaches and methodological considerations as well as the socio‐cultural contexts within which projects are carried out. We discuss situational tensions that might inhibit the capacity of adults and children to partner in co‐creating new knowledge and developing robust ways of working together. Finally, we draw attention to three significant dimensions within the findings: the influence on the children‐as‐researchers paradigm of hierarchical structures inherent to academic institutions; the importance of engaging with specific historical, political, and social contexts; and challenges for inclusion and diversity.
Injectable Bone Cement Reinforced with Gold Nanodots Decorated rGO‐Hydroxyapatite Nanocomposites, Augment Bone Regeneration
Authors: Chopra Vianni , Thomas Jijo , Kaushik Swati , Rajput Swati , Guha Rajdeep , Mondal Bidya , Naskar Sudip , Mandal Dipankar , Chauhan Gaurav , Chattopadhyay Naibedya , Ghosh Deepa 
Published: January 2023

AbstractInterest in the development of new generation injectable bone cements having appropriate mechanical properties, biodegradability, and bioactivity has been rekindled with the advent of nanoscience. Injectable bone cements made with calcium sulfate (CS) are of significant interest, owing to its compatibility and optimal self‐setting property. Its rapid resorption rate, lack of bioactivity, and poor mechanical strength serve as a deterrent for its wide application. Herein, a significantly improved CS‐based injectable bone cement (modified calcium sulfate termed as CSmod), reinforced with various concentrations (0–15%) of a conductive nanocomposite containing gold nanodots and nanohydroxyapatite decorated reduced graphene oxide (rGO) sheets (AuHp@rGO), and functionalized with vancomycin, is presented. The piezo‐responsive cement exhibits favorable injectability and setting times, along with improved mechanical properties. The antimicrobial, osteoinductive, and osteoconductive properties of the CSmod cement are confirmed using appropriate in vitro studies. There is an upregulation of the paracrine signaling mediated crosstalk between mesenchymal stem cells and human umbilical vein endothelial cells seeded on these cements. The ability of CSmod to induce endothelial cell recruitment and augment bone regeneration is evidenced in relevant rat models. The results imply that the multipronged activity exhibited by the novel‐CSmod cement would be beneficial for bone repair.
A New, Thorough Look on Unusual and Neglected Group III‐VI Compounds Toward Novel Perusals
Authors: Guzzetta Fabrizio , Jellett Cameron W. , Azadmanjiri Jalal , Roy Pradip Kumar , Ashtiani Saeed , Friess Karel , Sofer Zdeněk 
Published: January 2023

AbstractThe attention on group III‐VI compounds in the last decades has been centered on the optoelectronic properties of indium and gallium chalcogenides. These outstanding properties are leading to novel advancements in terms of fundamental and applied science. One of the advantages of these compounds is to present laminated structures, which can be exfoliated down to monolayers. Despite the large knowledge gathered toward indium and gallium chalcogenides, the family of the group III‐VI compounds embraces several other noncommon compounds formed by the other group III elements. These compounds present various crystal lattices, among which a great deal is offered from layered structures. Studies on aluminium chalcogenides show interesting potential as anodes in batteries and as semiconductors. Thallium (Tl), which is commonly present in the +1 oxidation state, is one of the key components in ternary chalcogenides. However, binary Tl–Q (Q = S, Se, Te) systems and derived films are still studied for their semiconducting and thermoelectric properties. This review aims to summarize the biggest features of these unusual materials and to shed some new light on them with the perspective that in the future, novel studies can revive these compounds in order to give rise to a new generation of technology.
Engineer RNA‐Protein Nanowires as Light‐Responsive Biomaterials
Authors: Younas Tayyaba , Liu Chang , Struwe Weston B. , Kukura Philipp , He Lizhong 
Published: January 2023

AbstractRNA molecules have emerged as increasingly attractive biomaterials with important applications such as RNA interference (RNAi) for cancer treatment and mRNA vaccines against infectious diseases. However, it remains challenging to engineer RNA biomaterials with sophisticated functions such as non‐covalent light‐switching ability. Herein, light‐responsive RNA‐protein nanowires are engineered to have such functions. It first demonstrates that the high affinity of RNA aptamer enables the formation of long RNA‐protein nanowires through designing a dimeric RNA aptamer and an engineered green fluorescence protein (GFP) that contains two TAT‐derived peptides at N‐ and C‐ termini. GFP is then replaced with an optogenetic protein pair system, LOV2 (light–oxygen–voltage) protein and its binding partner ZDK (Z subunit of protein A), to confer blue light‐controlled photo‐switching ability. The light‐responsive nanowires are long (>500 nm) in the dark, but small (20–30 nm) when exposed to light. Importantly, the co‐assembly of this RNA‐protein hybrid biomaterial does not rely on the photochemistry commonly used for light‐responsive biomaterials, such as bond formation, cleavage, and isomerization, and is thus reversible. These RNA‐protein structures can serve as a new class of light‐controlled biocompatible frameworks for incorporating versatile elements such as RNA, DNA, and enzymes.
Hydrogen‐Enhanced Catalytic Conversion of Amorphous Carbon to Graphene for Achieving Superlubricity
Authors: Li Ruiyun , Yang Xing , Ma Ming , Zhang Junyan 
Published: January 2023

AbstractThe solid‐state conversion of amorphous carbon into graphene is extremely difficult, but it can be achieved in the friction experiments that induce macroscale superlubricity. However, the underlying conversion mechanisms remain elusive. Here, the friction experiments with Cu nanoparticles and (non‐hydrogen (H) or H) a‐C in vacuum, show the H‐induced conversion of mechanical to chemical wear, resulting in the a‐C's tribosoftening and nanofragmentating that produce hydrocarbon nanoclusters or molecules. It is such exactly hydrocarbon species that yield graphene at hydrogen‐rich a‐C friction interface, through reaction of them with Cu nanoparticles. In comparison, graphene isn't formed at Cu/non‐H a‐C friction interface. Atomistic simulations reveal the hydrogen‐enhanced tribochemical decomposition of a‐C and demonstrate the energetically favorable graphitization transformation of hydrocarbons on Cu substrates. The findings are of importance to achieve solid‐state transformation between different carbon allotropes and provide a good strategy to synthesize other graphitic encapsulated catalysts with doped elements.