bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mouse Behavior on the Trial-Unique Nonmatching-to-Location (TUNL) Touchscreen Task Reflects a Mixture of Distinct Working Memory Codes and Response Biases
Authors: Bennett Daniel , Nakamura Jay , Vinnakota Chitra , Sokolenko Elysia , Nithianantharajah Jess , van den Buuse Maarten , Jones Nigel C. , Sundram Suresh , Hill Rachel 
Published: June 2023

The trial-unique nonmatching to location (TUNL) touchscreen task shows promise as a translational assay of working memory (WM) deficits in rodent models of autism, ADHD, and schizophrenia. However, the low-level neurocognitive processes that drive behavior in the TUNL task have not been fully elucidated. In particular, it is commonly assumed that the TUNL task predominantly measures spatial WM dependent on hippocampal pattern separation, but this proposition has not previously been tested. In this project, we tested this question using computational modeling of behavior from male and female mice performing the TUNL task (N= 163 across three datasets; 158,843 trials). Using this approach, we empirically tested whether TUNL behavior solely measured retrospective WM, or whether it was possible to deconstruct behavior into additional neurocognitive subprocesses. Overall, contrary to common assumptions, modeling analyses revealed that behavior on the TUNL task did not primarily reflect retrospective spatial WM. Instead, behavior was best explained as a mixture of response strategies, including both retrospective WM (remembering the spatial location of a previous stimulus) and prospective WM (remembering an anticipated future behavioral response) as well as animal-specific response biases. These results suggest that retrospective spatial WM is just one of a number of cognitive subprocesses that contribute to choice behavior on the TUNL task. We suggest that findings can be understood within a resource-rational framework, and use computational model simulations to propose several task-design principles that we predict will maximize spatial WM and minimize alternative behavioral strategies in the TUNL task.SIGNIFICANCE STATEMENTTouchscreen tasks represent a paradigm shift for assessment of cognition in nonhuman animals by automating large-scale behavioral data collection. Their main relevance, however, depends on the assumption of functional equivalence to cognitive domains in humans. The trial-unique, delayed nonmatching to location (TUNL) touchscreen task has revolutionized the study of rodent spatial working memory. However, its assumption of functional equivalence to human spatial working memory is untested. We leveraged previously untapped single-trial TUNL data to uncover a novel set of hierarchically ordered cognitive processes that underlie mouse behavior on this task. The strategies used demonstrate multiple cognitive approaches to a single behavioral outcome and the requirement for more precise task design and sophisticated data analysis in interpreting rodent spatial working memory.
Plasma fractalkine contributes to systemic myeloid diversity and PD‐L1/PD‐1 blockade in lung cancer
Authors: Bocanegra Ana , Fernández‐Hinojal Gonzalo , Ajona Daniel , Blanco Ester , Zuazo Miren , Garnica Maider , Chocarro Luisa , Alfaro‐Arnedo Elvira , Piñeiro‐Hermida Sergio , Morente Pilar , Fernández Leticia , Remirez Ana , Echaide Miriam , Martinez‐Aguillo Maite , Morilla Idoia , Tavira Beatriz , Roncero Alejandra , Gotera Carolina , Ventura Alfonso , Recalde Nerea , Pichel José G , Lasarte Juan José , Montuenga Luis , Vera Ruth , Pio Ruben , Escors David , Kochan Grazyna 
Published: June 2023

AbstractRecent studies highlight the importance of baseline functional immunity for immune checkpoint blockade therapies. High‐dimensional systemic immune profiling is performed in a cohort of non‐small‐cell lung cancer patients undergoing PD‐L1/PD‐1 blockade immunotherapy. Responders show high baseline myeloid phenotypic diversity in peripheral blood. To quantify it, we define a diversity index as a potential biomarker of response. This parameter correlates with elevated activated monocytic cells and decreased granulocytic phenotypes. High‐throughput profiling of soluble factors in plasma identifies fractalkine (FKN), a chemokine involved in immune chemotaxis and adhesion, as a biomarker of response to immunotherapy that also correlates with myeloid cell diversity in human patients and murine models. Secreted FKN inhibits lung adenocarcinoma growth in vivo through a prominent contribution of systemic effector NK cells and increased tumor immune infiltration. FKN sensitizes murine lung cancer models refractory to anti‐PD‐1 treatment to immune checkpoint blockade immunotherapy. Importantly, recombinant FKN and tumor‐expressed FKN are efficacious in delaying tumor growth in vivo locally and systemically, indicating a potential therapeutic use of FKN in combination with immunotherapy.
A quantum-­mechanical particle in a time-­dependent potential field
Authors: Turinov A. 
Published: June 2023

The behavior of a particle moving according to the laws of quantum mechanics in a field, which potential changes over time, is studied. The method of unitary transformations for solving the temporal Schrödinger equation is considered. The reduced Hamiltonian of the system of a quantum­-mechanical particle in time­-dependent potential is obtained, as well as the total operator of the evolution of such a system. We find a new version of the unitary transformation, which, compared to the known ones, simplifies solving the problem in analytical form. This transformation associates the linear potential quantum model with time-­dependent parameters and free­particle system. Based on the constructed evolution operator, we consider the wave packet dispersion. It is shown that the wave packet dispersion for this model is the same as that for a free particle. This conclusion is the general result of the behavior of a quantum­mechanical particle moving in the field of a time­dependent linear potential.
Composition variations and UV irradiation effect on charge transfer in PbMoO4 single crystals
Authors: Bochkova T. M. , Trubitsyn M. P. , Volnianskii M. D. , Volnianskii D. M. 
Published: June 2023

The effect of nonstoichiometry of the composition, PbO polymorphism, and preliminary irradiation with ultraviolet light on electrical conductivity of alternating current (AC) was studied in PbMoO4 crystals. The crystals were grown by Czochralski method in a direction deviated by 30° from a-axis in (001) plain. The charge was prepared from MoO3 and PbO, lead oxide was used of α- or β- structural modifications. The reagents were taken both in a stoichiometric ratio and with an excess of 0.5 mol % of MoO3. It was shown that the magnitude of the dark and irradiation-induced AC conductivity was affected both by the type of polymorphic form of PbO and by the excess amount of MoO3. The influence of the PbMoO4 crystal structural disorder on charge transfer processes are discussed within the framework of the model of hopping conduction in disordered media.
Fabrication and optical characteristics of opal photonic crystal films and heterostructures
Authors: Mukharovska V. S. , Derhachov M. P. , Moiseyenko V. M. 
Published: June 2023

The relevance of fabrication and investigation of opals and opal-based structures is due to their ability to control the emission and propagation of light. Using the method of vertically moving meniscus we obtain both single opal films and two-film heterostructures. By examining reflectance spectra, we analyze the influence of the ratio of synthesis components on silica particle diameter. Features of the heterostructure reflectance spectrum are also discussed by considering the contribution of light scattering by the interface.
Study of a finite linear waveguide antenna array with dielectric plugs
Authors: Magro V. I. , Morozov V. M. 
Published: June 2023

A finite waveguide antenna array of open ends of the waveguides, which are surrounded by a metal screen, is under consideration. The influence of the permittivity and the height of dielectric plugs on the modulus of the reflection coefficient in waveguides of the finite antenna array is studied. Dielectric plugs with different values of permittivity are considered. It is shown that dielectric plugs effectively match the impedance of the antenna array for the case of a slight deviation of the beam from the normal to the array.
Students’ Perceptions on the Implementation of Online Learning at a State High School in Yogyakarta
Authors: Irmalia Virliana 
Published: June 2023

Introduction - Since Covid-19 has spread to Indonesia, the teaching and learning process is carried out online. During the implementation of online teaching and learning process, students faced challenges.
The researcher also presents the research questions and objectives of the research. The benefits of the research for the teachers, the students, other researchers and the institution are provided in the section of significance of the study. Then, the researcher presents the organization of the chapters.
Purpose - This research aimed to find out students’ challenges and strategies when doing online learning.
Methodology - The researcher used a descriptive qualitative design. The researcher used interview as the data collection technique and interview guideline as the instrument of the research.
Findings - There are eight challenges faced by the students, namely the unexplained materials, lack effective interaction between the students and the teacher, the inappropriate teacher’s time management, bad internet connection, the teachers’ unavailability to respond the students’ questions, incompetent teachers on online application, uncooperative and passive peer students, and difficulty in discussing in group work. Meanwhile, the strategies used by the students to overcome challenges when doing online learning included first by joining private course and looking for other sources, second by requesting additional time, third by prepared collaboration with friends, fourth by providing feedback and suggestions for the teachers, fifth by coordinating group members and being more active.
Originality - In the application of online learning in the teaching and learning process, there are challenges that must be faced by students. The aims of this study is the researcher believe the students’ perceptions are very important in ensuring the quality of learning process, as the students are the most important subject who are affected by the implementation of online learning.
EFFECT OF IRON (III)-HYDROXIDE POLYMALTOSE COMPLEX ON ANEMIA: A LITERATURE STUDY
Authors: Insani Indah , Siregar Vrili , Girsang Osi 
Published: June 2023

Health is an important thing to be maintained in life. In the development of this era, many people, especially teenagers, do not pay attention to the intake of nutrients, iron, and protein that enter the body causing disease. One of the diseases that can be caused is anemia. According to the National Institute of Health (NIH) the cause of anemia can be caused by a lack of iron, vitamins, or chronic disease. In Indonesia, the occurence of anemia is fairly high. still quite high. To overcome anemia, iron complex compounds can be used because one of the things that causes anemia is a lack of iron in the body. This study aims to describe the application of iron (III)-hydroxide polymaltose complex as an effective compound in overcoming of iron deficiency anemia.This study was compiled from the online literature of local and international journals using secondary data that had been screened based on keywords. The results of the study concluded that iron (III)-Hydroxide Polymaltose Complex Compounds can be used to treat anemia.This literature study covers recently published (year > 2000) reports on iron (III)-Hydroxide Polymaltose Complex Compounds in overcoming the health problem of anemia.
Assessment of depression, anxiety and stress among patients with type II diabetes mellitus attending a tertiary care centre
Authors: Hazarika Kasturi , Ali M. Fahad , Agarwal Saurabh , Verma Shivendra , Singh Vipul 
Published: June 2023

Background: India is home to 17% diabetic (~80 million) population of world and is expected to increase to 135 million by 2045. Chronic illnesses association with psychiatric morbidity. Positive relationship exists between diabetes and psychiatric disorders and have definite negative impact on self-care practices, worsening physical and mental health, diminishing quality of life (QoL) and poor resulting in greater economic burden both to family and society.
Method: A cross-sectional study was conducted in a diabetes clinic of a tertiary care facility in North India. Hindi version of DASS 21 was used to ascertain the psychological health of patients which determine the presence of depression, anxiety and stress. Data were analysed using SPSS 20.0
Results: We found a high prevalence of depression (49.7%), anxiety (69.7%) and stress (68.3%) among patients belonging to lower socioeconomic status, rural residence and lower literacy rates/illiteracy. The prevalence of depression was higher among females.
Conclusions: There is a high prevalence of psychiatric morbidity among the North Indian diabetic population which shows some variability with changing demographic profile.
İmâmet Problemine Sünnî & Şiî Sentezci Bir Yaklaşım: Şemseddin es-Semerkandî'nin Siyaset Tasavvuru
Authors: TANRIBİLİR Tarık 
Published: June 2023

İslam düşünce tarihinin kırılma noktalarından birini teşkil eden problemlerden birisi de devlet başkanlığıdır. Müslümanlar, bu konuda yalnızca teorik ihtilafa düşmemiş, fiilî mücadelelere de girmişlerdir. Bu anlaşmazlık, etkisini günümüze kadar devam ettirmiş ve Müslümanların hem dini hem de dünyevi görüşlerini şekillendirmiştir. Hz. Muhammed’in rolünü üstlenecek ve Müslümanların dini ve dünyevi işlerini tanzim edecek adayın kimliği tartışması, teorik ve pratik alanda kendisini gösteren tarihsel çekişmelere sahne olmuştur. Siyasi tezleri meşrulaştırmak amacıyla ileri sürülen dini referanslar söz konusu tezlerin kurumsallaşmasına neden olmuş ve temelde siyasi karakterli hadiseler din ile ilişkilendirilmiştir. İslam mezhepleri arasında özellikle Şîa, devlet başkanlığı problemine varoluşsal bir anlam yüklemiş, bütün dini ve dünyevi görüşlerini bu eksende şekillendirmiştir. Devlet başkanlığı problemini neredeyse bir iman esası olarak benimseyen Şîa, devlet başkanlarına peygamberliğe yakın bir mertebe tahsis etmiştir. Zeydiyye, siyaset konusunda Şîa’nın Ehl-i Sünnet’e en yakın kolu olarak dikkat çekmektedir. Onlar, devlet başkanının özellikleri, Hz. Ali haricindeki devlet başkanları ve sahâbe hakkında daha ılımlı düşünmektedir.
Ehl-i Sünnet, devlet başkanlığını esasen fıkhî-siyasî bir konu olarak değerlendirmektedir. Devlet başkanlığını bir iman problemi olarak gören ve bu problemi sistemleştiren Şîa’ya itiraz etmek amacıyla bile olsa bu tartışmayı inanç alanına taşımak siyaset düşüncesinde Şîa’nın Ehl-i Sünnet üzerindeki ilk etkilerini göstermektedir. Şîa, Hz. Ali’nin devlet başkanlığını savunmak ve diğerlerinin meşruiyetini sorgulamak amacıyla meseleyi inanç alanına taşımış, çeşitli dini metinlere referansla Hz. Ali’nin Allah katında daha üstün, dolayısıyla da devlet başkanlığına daha layık zât olduğunu kanıtlamak istemiştir. Şîa, siyasi tezlerini güçlü bir şekilde kanıtlamak ve mutlak otorite kurmak amacıyla meseleyi dogmatik bir tarzda incelemiştir. Bu yöntemin kaçınılmaz bir sonucu olarak devlet başkanlığı kurumu ilahi yetkilerle donatılmıştır. Devlet başkanlarının nas ile tayin edilmesi ve ismet sıfatına sahip olması tezleri bu yaklaşımın en somut yansımalarıdır. Ehl-i Sünnet, Hz. Ali'nin üstünlüğünü savunan Şîa’ya karşı Hz. Ebubekir’in üstünlüğünü savunarak meşruiyetini temellendirmeye çalışmıştır. Bu yaklaşım, Şîa’ya kendi yöntemiyle etkili cevap verme misyonunu deruhte ettiği kadar yöntemsel etkileşimi de gözler önüne sermektedir.
Siyaset tasavvurunu incelediğimiz Şemseddin es-Semerkandî, Hanefî-Mâtürîdî kelam geleneğine mensup bir Ehl-i Sünnet âlimidir. O, siyasi görüşleri ve üslubundan dolayı kimileri tarafından Şiî olarak da nitelendirilmiştir. Semerkandî’nin siyaset tasavvurunu onun genel kelam felsefesi bağlamında inceleyerek mezhepsel aidiyeti ve siyasi duruşu hakkında daha net bilgi sahibi olabiliriz. O, diğer meselelerde olduğu gibi siyaset konusunda da tahkik yöntemini benimsemiş, Ehl-i Sünnet ana caddesine bağlı kalmakla beraber kendi özgün üslup ve görüşlerini ortaya koymuştur.
Interaksi Komunikasi Umat Beragama di Daerah Mayoritas Karo
Authors: Lubis Miranda W. , Rasyid Abdul 
Published: June 2023

Artikel ini bertujuan untuk membahas interaksi komunikasi umat beragama di daerah mayoritas Karo di Desa Durin Jangak. Kerukunan umat beragama mengacu pada kerja sama umat beragama yang dilandasi oleh toleransi. Dalam pengalaman ajaran agama, harus ada saling pengertian, saling menghargai, dan kesetaraan. Maka itu, mencermati hubungan sesama umat beragama, tujuan penelitian ini adalah untuk mengulas lebih dalam bagaimana interaksi komunikasi umat beragama yang ada di daerah mayoritas suku Karo pada Desa Durin Jangak. Teknik pengumpulan data In-Dept Interview digunakan dalam pendekatan penelitian kualitatif fenomenologis. Ini termasuk wawancara mendalam dengan informan dalam bentuk pertanyaan atau pembicaraan lisan. Hasil penelitian menunjukkan bahwa interaksi komunikasi umat beragama di Desa Durin Jangak yang mayoritasnya suku Karo adalah saling menghargai, tidak menghakimi, tidak mengintimidasi, saling menyapa, menerima perbedaan agama dan pendapat, dan tidak melupakan toleransi sebagai perwujudan menghindar konflik antar umat beragama.
ANALISIS INSIDEN KESELAMATAN PASIEN BERDASARKAN KUALITAS TEAMWORK DAN COORDINATION MANAJEMEN RUMAH SAKIT ISLAM AHMAD YANI SURABAYA
Authors: Adriansyah Agus Aan , Setianto Budhi , Sa'adah Nikmatus , Lestari Indah , Nashifah Nur Sa'adah , Anggarwati Fauziah Rizki , Arindis Pinky Ayu Marsela 
Published: June 2023

Peningkatan insiden keselamatan pasien di rumah sakit sering terjadi. Kerja tim antar individu dalam unit kerja dan koordinasi antar unit pelayanan merupakan salah satu upaya untuk mengurangi lejadian yang terkait dengan masalah keselamatan pasien. Penelitian ini bertujuan untuk menganalisis peranan kerja tim antar individu dalam unit kerja dan koordinasi antar unit pelayanan terhadap terjadinya insiden keselamatan pasien (IKP) di rumah sakit. Penelitian ini dilakukan di RS Islam Surabaya pada tahun 2020, dilakukan secara deskriptif dengan pendekatan cross-sectional. Unit analisis ditentukan secara total sampling meliputi 18-unit kerja yang memberikan pelayanan kepada pasien dengan responden adalah pimpinan unit atau ruangan, penanggung jawab shift kerja dan penanggung jawab mutu keselamatan pasien. Pengumpulan data responden terkait kerja tim dan koordinasi dalam penanganan keselamatan pasien. Pengumpulan data dilakukan secara online dengan menggunakan google form, dan dianalisis menggunakan tabulasi silang serta pendekatan Pareto (memiliki keterkaitan jika ditemukan perbedaan >20% antara variabel bebas dan variabel terikat). Hasil penelitian menunjukkan mayoritas kerja tim sudah baik (83,3%), pelaksanaan koordinasi mayoritas masih kurang baik (83,3%) dan insiden keselamatan pasien masih tergolong tinggi (33,3%). Insiden didominasi oleh Nyaris Cedera dengan peringkat hijau, dan unit rawat jalan memiliki insiden tertinggi. Kerja tim dan koordinasi berperan penting terhadap insiden keselamatan pasien dengan selisih persentase masing-masing sebesar 40,0% (> 20,0%) dari setiap kategori pada kerja tim maupun koordinasi. Penelitian ini menunjukkan kerja tim dan koordinasi berperan penting terhadap terjadinya IKP di rumah sakit. Oleh sebab itu, perlu saling support antar individu dalam tim di setiap unit kerja serta rutin melakukan pertemuan secara bersama membahas patient safety.
Kata kunci: insiden keselamatan pasien, kerja tim, koordinasi, rumah sakit
KAJIAN RISIKO KESEHATAN KESELAMATAN KERJA PENYEMPROTAN DISINFEKTAN PADA PETUGAS PEMAKAMAN COVID-19
Authors: Henary Pratmasita Rahma , Indrayani Reny 
Published: June 2023

Penyemprotan disinfektan merupakan salah satu cara yang dilakukan untuk mencegah penularan Covid-19. Penyemprotan disinfektan mengandung cairan bersifat destruktif sehingga menimbulkan iritasi pada kulit, mata, dan saluran pernapasan. WHO tidak menyarankan penyemprotan disinfektan dilakukan ke tubuh manusia karena dapat membahayakan kesehatan. Penelitian ini bertujuan untuk mengidentifikasi risiko kesehatan dan keselamatan kerja penyemprotan disinfektan pada petugas pemakaman Covid-19 di BPBD Kabupaten Lumajang. Penelitian ini bersifat deskriptif dengan desain observasional. Pengumpulan data dilakukan dengan wawancara dan observasi menggunakan lembar Job Safety Analysisis. Penelitian dilakukan pada anggota Tim Reaksi Cepat sebanyak 21 orang yang menjadi petugas pemakaman Covid-19. Hasil penelitian menunjukkan bahwa sebagian petugas pemakaman Covid-19 pernah merasakan keluhan iritasi kulit seperti gatal-gatal, terasa terbakar, dan kulit pecah-pecah. Tingkat risiko penyemprotan disinfektan dibedakan berdasarkan tahapan kegiatannya yaitu saat pembuatan disinfektan dan saat penyemprotan disinfektan. Potensi risiko yang terjadi saat pembuatan disinfektan meliputi iritasi kulit, kulit pecah-pecah, terasa terbakar, dan iritasi mata yang tergolong dalam tingkat risiko acceptable serta gangguan pernapasan, sesak napas, dan sakit tenggorokan yang tergolong tingkat risiko priority 3. Saat penyemprotan disinfektan, terdapat tingkatan risiko yang terjadi mulai dari risiko yang acceptable hingga priority 1. Potensi risiko pada kategori acceptable meliputi terpeleset, tersandung, dan terjatuh yang dapat terjadi karena kurangnya konsentrasi ketika bekerja di malam hari. Sementara potensi risiko pada kategori priority 1 meliputi iritasi kulit, gatal-gatal, kulit pecah-pecah, terasa terbakar, dan kulit kemerahan. Saran yang dapat diberikan adalah dengan menggunakan APD saat pembuatan disinfektan seperti handscoon, masker, face shield serta menggunakan coverall yang tahan terhadap cairan.
Kata Kunci: kesehatan keselamatan kerja, penyemprotan disinfektan, petugas pemakaman Covid-19