bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN MODEL DISCOVERY LEARNING DENGAN PENDEKATAN KONTEKSTUAL UNTUK MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH
Authors: Dicca Mei Santri  , Rosmaiyadi  , Mariyam  
Published: February 2023

Penelitian ini bertujuan untuk mengetahui perbedaan peningkatan kemampuan pemecahan masalah siswa, keterlaksanaan model Discovery Learning dengan pendekatan kontekstual, dan karakter kreatif belajar siswa setelah diterapkan model Discovery Learning dengan pendekatan kontekstual pada materi sistem persamaan linear dua variabel. Penelitian ini dilaksanakan di SMP Negeri 7 Singkawang pada semester genap tahun ajaran 2021/2022. Adapun sampel dalam penelitian ini adalah siswa kelas VIII A dan VIII C. Jenis dan desain penelitian yang digunakan adalah penelitian kuantitatif dengan desain Quasi Experimental pada bentuk The Nonequivalent Pretest Posttest Control Group Design. Untuk teknik analisis data dalam penelitian ini adalah uji N-gain, uji normalitas, uji homogenitas, uji mann whitey u-test, persentase keterlaksanaan, dan persentase karakter kreatif siswa. Berdasarkan hasil analisis data dapat disimpulkan bahwa: 1) terdapat perbedaan peningkatan kemampuan pemecahan masalah yang menggunakan model Discovery Learning dengan pendekatan kontekstual lebih baik dari pada model pembelajaran langsung, 2) pada pembelajaran yang menggunakan model Discovery Learning dengan pendekatan kontekstual dapat terlaksana dengan baik, dan 3) karakter kreatif belajar siswa tergolong tinggi setelah diterapkannya model Discovery Learning dengan pendekatan kontekstual.
Pengembangan Sistem Pendukung Keputusan Penelusuran Minat Bakat Siswa SMP Dalam Memilih Jurusan di SMK Berbasis Web
Authors: SAS Abdillah , Andi Muh Akbar Saputra  , Muh Fadli Fausi Sahlan  
Published: February 2023

The study aims at (1) designing the development of SPK (Decision Support System) of studens’ talent interests with web basis, (2) determining studens majors based on talents and interests, (3) designing the easier application, research population was the students of SMP who where about to graduate of students of SMK who were just accepted in the school. The SPK being built can determine the majors, learning styles, and personality of students based on the answers being questioned. Data colleting techniques used in this study were interview, literature review, and questionnaire. Data processing instruments of the study were structural equation modeling, black box testing, alpha, and beta testing.
The results of the study reveal that the SPK of talents and interests with web basis can be designed and easier for the students in determining the majors at SMK because the SPK made had been tested fuctionality with very feasible category with the ttal percentage of 100%. Based on the usability test, this SPK is categorized as very good with the percentage of 100%. Based on the usability test, this SPK is categorized as very good with the percentage of 89.63%. Based on the result of SEM test by including various factors which were considered as influencing the saticfaction of SPK users, it is concluded that the factors of system quality, information quality, and interation quality influence the satisfaction of SPK users; wheres, the service quality has no influence of satisfaction to SPK users
Keyword — decision support systems, majors in SMK, web applications, structural equation modeling.
Green synthesis and characterization of silver nanoparticles through the Piper cubeba ethanolic extract and their enzyme inhibitory activities
Authors: Ahmad Khalil , Asif Hafiz Muhammad , Afzal Taimoor , Khan Mohsin Abbas , Younus Muhammad , Khurshid Umair , Safdar Maryem , Saifulah Sohaib , Ahmad Bashir , Sufyan Abubakar , Ansari Siddique Akber , Alkahtani Hamad M. , Ansari Irfan Aamer 
Published: February 2023

Introduction: The area of “Green Synthesis of Nano-medicine,” as compared to its synthetic counterparts, is a relatively safer research technology for various biomedical applications, including identification, therapeutic application, and prevention of pathological conditions, pain control, safety, and development of human wellness. The present study explored the synthesis and characterization of AgNPs using the ethanolic extract of Piper cubeba fruit as a reducing and stabilizing agent and its potential as an enzyme inhibitory agent. Urease inhibitors are helpful against many severe diseases, including gastric ulcers induced by Helicobacter pylori.Method: The fruits of the Piper cubeba plant were taken and ground to a fine powder. Plant material was added to 500 ml ethanol, and the mixture was filtered. The solvent of the filtrate was evaporated, and a thick, gummy extract was obtained and stored at 4°C in the refrigerator. AgNPs were green synthesized from solutions of AgNO3 using the P. cubeba extract, which was indicated by a change in the color from light brown to deep brown. The synthesized AgNPs were characterized via Ultraviolet-visible (UV-Vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM).Results and Discussion: Analysis showed the reduction of Ag+ to Ag0 at room temperature (25°C), and the average particle size of AgNPs was in the range of 40–80 nm. Consequently, the synthesized AgNPs were evaluated for their anti-urease activity. The maximum urease inhibition of the Piper cubeba ethanolic extract was 88.5% at 5 mg conc., and of derived nanoparticles was 78.6% at 0.05 mg conc. The results were nearly similar to the control drug, i.e., thiourea (0.5 and 0.6 mM conc., respectively).Conclusion: The study concluded that the P. cubeba extract, as well as its green-derived AgNPs, might prove to be a better and safer substitute for their enzyme inhibitory potential in emerging medicine and novel drug delivery techniques to improve and maintain human health.
Association between skipping breakfast and prediabetes among adolescence in Japan: Results from A-CHILD study
Authors: Miyamura Keitaro , Nawa Nobutoshi , Isumi Aya , Doi Satomi , Ochi Manami , Fujiwara Takeo 
Published: February 2023

ObjectiveAdolescents with prediabetes are at high risk of developing type 2 diabetes in later life. It is necessary to identify risk factors for prediabetes in adolescents. This study aimed to examine the association between skipping breakfast and prediabetes among adolescents in Japan.Study designWe used the population-based cross-sectional data of eighth grade in junior high school students from the Adachi Child Health Impact of Living Difficulty (A-CHILD) study conducted in Adachi City, Tokyo, Japan, in 2016, 2018, and 2020. Skipping breakfast was assessed using self-reported questionnaires (N=1510). Prediabetes was defined as hemoglobin A1c (HbA1c) levels of 5.6-6.4%. The association between skipping breakfast and prediabetes was evaluated using multivariate logistic regression analysis. Stratified analysis was also performed using BMI, 1 SD or more, or less than 1SD, as overweight was defined as 1SD or more.ResultsStudents who skipped breakfast were 16.4% (n=248). The prevalence of prediabetes was 3.8% (n=58). Skipping breakfast exhibited a significant association with prediabetes (OR:1.95, 95% CI: 1.03 to 3.69) after adjusting for sex, annual household income, family history of diabetes mellitus, BMI, and survey year. Stratified analysis showed stronger association among students with overweight (BMI ≥1SD) (OR=4.31, 95% CI 1.06-17.58), while non-sigificant among students without overweight (BMI&lt;1SD) (OR=1.62, 95% CI 0.76-3.47).ConclusionsSkipping breakfast in Japanese adolescents, especially those with overweight, was associated with prediabetes. The promotion of avoiding skipping breakfast may help to prevent prediabetes.
Pesticide residues risk assessment and quality evaluation of four characteristic fruits in Zhejiang Province, China
Authors: Liu Yuhong , Bei Ke , Zheng Weiran , Yu Guoguang , Sun Caixia 
Published: February 2023

Miaoxi yellow peach, lanxi loquat, qingyuan sweet spring tangelo and haining pear are characteristic fruits in Zhejiang Province, China. This study investigated the levels of pesticides in these fruits in Zhengjiang Province, China, along with the associated risk of dietary exposure for consumer. In total, 25 pesticides were detected in the 68 samples. The pesticide detection rate of the samples was 95.59%, and the level of prochloraz in a pear sample was found to be higher than the maximum residue limit (MRL) in China. Overall, the pesticide residues were very low, and residue levels ranged from 0.001 to 1.06 mg/kg, of which 80.88% simultaneously occurred with 2–8 mixed residues. Acetamiprid (54.55%), carbendazim (64.71%), prochloraz (94.74%) and pyraclostrobin (85.71%) had the highest detection rate in the four fruits, respectively. A risk assessment of human exposure to pesticides via the intake of the four fruit types was performed, and the chronic intake risk (HQc) and acute intake risk (HQa) of a single pesticide and the hazard index (HI) of the mixture of pesticides for adults and children from the four fruit types were found to be less than 1, the exposure assessment showed that the levels of pesticides in the four fruit types were safe for human consumption. In addition, the quality of the four fruit types was analyzed and found to be not stable enough. We suggest strengthening standardized planting and management technology to improve product quality and safety, in particular, cultivators should use pesticides reasonably and control the pre-harvest interval (PHI) in order to better protect consumer health.
Enhancing genetic gain through the application of genomic selection in developing irrigated rice for the favorable ecosystem in Bangladesh
Authors: Biswas Partha S. , Ahmed M. M. Emam , Afrin Wazifa , Rahman Anisar , Shalahuddin A. K. M. , Islam Rafiqul , Akter Fahamida , Syed Md Abu , Sarker Md Ruhul Amin , Ifterkharuddaula K. M. , Islam Mohammad Rafiqul 
Published: February 2023

Increasing selection differential and decreasing cycle time, the rate of genetic improvement can be accelerated. Creating and capturing higher genetic with higher accuracy within the shortest possible time is the prerequisite for enhancing genetic gain for any trait. Comprehensive yield testing at multi-locations at early generations together with the shortest line fixation time can expedite the rapid recycling of parents in the breeding program through recurrent selection. Genomic selection is efficient in capturing high breeding value individuals taking additive genetic effects of all genes into account with and without extensive field testing, thus reducing breeding cycle time enhances genetic gain. In the Bangladesh Rice Research Institute, GS technology together with the trait-specific marker-assisted selection at the early generation of RGA-derived breeding lines showed a prediction accuracy of 0.454–0.701 with 0.989–2.623 relative efficiency over the four consecutive years of exercise. This study reports that the application of GS together with trait-specific MAS has expedited the yield improvement by 117 kg ha−1·year−1, which is around seven-fold larger than the baseline annual genetic gain and shortened the breeding cycle by around 1.5 years from the existing 4.5 years.
Microrna-206 induces hypoxic necrosis of femoral head by inhibiting VEGF/PI3K/AKT signaling pathway
Authors: Wu Xingjing , Tao Zhoushan , Cheng Wenjing 
Published: February 2023

The most common form of non-traumatic necrosis of the femoral head is anoxic necrosis of the femoral head, which is a metabolic disease, mainly involving young and middle-aged people. Apoptosis and its related signal regulation pathway play an important role in the occurrence and development of hypoxic necrosis of the femoral head. In order to investigate the possible pathological manifestations of miR-206 and VEGF/PI3K/AKT signal pathway genes and their interactions in hypoxic necrosis of the femoral head, this paper intended to systematically study the expression and regulation mechanism of miR-206 and VEGF/PI3K/AKT signal pathway genes. The interaction between miR-206 and VEGF/PI3K/AKT signaling pathway and its regulation on apoptosis, differentiation and proliferation of human osteoblast cell line hFOB1.19 (SV40 transfer of human osteoblasts) were studied by double luciferase reporter gene analysis, overexpression and inhibition of miR-206, and gene silencing of VEGF/PI3K/AKT signaling pathway. After 24 h and 48 h of intervention with MicroRNA 206 on osteoblasts, it was found that the fluorescence intensity of caspase-3 was higher than that of 0 h group (p &lt; 0.05). This paper has provided an important research basis for the research of femoral head necrosis and the development of new diagnosis and therapeutic drugs for this kind of disease. It also has provided a reference for the further promotion of the chemotherapy drug delivery system.
The effects of conjugated linoleic acid supplementation on inflammatory cytokines and adipokines in adults: A GRADE-assessed systematic review and dose–response meta-analysis
Authors: Rastgoo Samira , Shimi Ghazaleh , Shiraseb Farideh , Karbasi Ashkan , Ashtary-Larky Damoon , Yousefi Mohsen , Golalipour Elnaz , Asbaghi Omid , Zamani Mohammad 
Published: February 2023

Background and aimsMany studies have investigated the effect of conjugated linoleic acid (CLA) supplementation on inflammatory cytokines and adipokines. However, the results of these studies are not consistent. Therefore, this systematic review and meta-analysis were designed to comprehensively evaluate the effect of CLA supplementation on inflammatory cytokines and adipokines.MethodsRandomized controlled trials (RCTs) examining the effects of CLA supplementation on C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), adiponectin, and leptin, published up to March 2022, were identified through PubMed, SCOPUS, and ISI Web of Science databases. A random-effects model was used to calculate weighted mean differences (WMDs) with 95% confidence intervals (CI) for 42 studies that included 1,109 participants.ResultsFindings from 42 studies with 58 arms indicated that CLA supplementation significantly decreased IL-6 and TNF-α levels and also slightly increased CRP levels. However, adiponectin and leptin levels did not change after CLA supplementation. A subgroup analysis found that CLA supplementation reduced adiponectin and leptin in women.ConclusionOur results demonstrated that CLA supplementation increased CRP levels and decreased TNF-α and IL-6 levels. Therefore, it seems that CLA can have both proinflammatory and anti-inflammatory roles.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier (CRD42022331110).
Association between serum folate levels and blood eosinophil counts in American adults with asthma: Results from NHANES 2011–2018
Authors: Wen Jun , Wang Changfen , Giri Mohan , Guo Shuliang 
Published: February 2023

BackgroundTo date, many researches have investigated the correlation of folate and asthma occurrence. Nevertheless, few studies have discussed whether folate status is correlated with dis-ease severity, control or progression of asthma. So, we explored the correlation of serum folate and blood eosinophil counts in asthmatic adults to gain the role of folate in the control, progression, and treatment of asthma.MethodsData were obtained from the 2011–2018 NHANES, in which serum folate, blood eosinophils, and other covariates were measured among 2332 asthmatic adults. The regression model, XGBoost algorithm model, and generalized linear model were used to explore the potential correlation. Moreover, we conducted stratified analyses to determine certain populations.ResultsAmong three models, the multivariate regression analysis demonstrated serum folate levels were negatively correlated with blood eosinophil counts among asthmatic adults with statistical significance. And we observed that blood eosinophil counts decreased by 0.20 (-0.34, -0.06)/uL for each additional unit of serum folate (nmol/L) after adjusting for confounders. Moreover, we used the XGBoost Algorithm model to identify the relative significance of chosen variables correlated with blood eosinophil counts and observed the linear relationship between serum folate levels and blood eosinophil counts by constructing the generalized linear model.ConclusionsOur study indicated that serum folate levels were inversely associated with blood eosinophil counts in asthmatic adult populations of America, which indicated serum folate might be correlated with the immune status of asthmatic adults in some way. We suggested that serum folate might affect the control, development, and treatment of asthma. Finally, we hope more people will recognize the role of folate in asthma.
Response mechanisms of bacterial communities and nitrogen cycle functional genes in millet rhizosphere soil to chromium stress
Authors: Bai Xue , Li Yvjing , Jing Xiuqing , Zhao Xiaodong , Zhao Pengyu 
Published: February 2023

IntroductionA growing amount of heavy metal contamination in soil disturbs the ecosystem’s equilibrium, in which microbial populations play a key role in the nutrient cycle of soils. However, given the different sensitivity of microbial communities to different spatial and temporal scales, microbial community structure and function also have varied response mechanisms to different heavy metal contaminated habitats.MethodsIn this study, samples were taken prior to Cr stress (CK) and 6 h and 6 days after Cr stress (Cr_6h, Cr_6d) in laboratory experiments. High-throughput sequencing revealed trends in the structure and diversity of the bacterial communities, and real-time fluorescence quantitative polymerase chain reaction (qPCR) was used to analyze trends in nitrogen cycle functional genes (AOA-amoA, AOB-amoA, narG, nirK, and nifH).ResultsThe findings showed that (1) the composition structure of the soil bacterial community changed considerably in Cr–stressed soils; α-diversity showed significant phase transition characteristic from stress to stability (p &lt; 0.05). (2) With an overall rising tendency, the abundance of the nitrogen cycle functional genes (AOA-amoA and AOB-amoA) decreased considerably before increasing, and α-diversity dramatically declined (p &lt; 0.05). (3) The redundancy analysis (RDA) and permutational multivariate analysis of variance (PERMANOVA) tests results showed that the soil physicochemical parameters were significantly correlated with the nitrogen cycle functional genes (r: 0.4195, p &lt; 0.01). Mantel analysis showed that available nitrogen (N), available potassium (K), and available phosphorus (P) were significantly correlated with nifH (p = 0.006, 0.008, 0.004), and pH was highly significantly correlated with nifH (p = 0.026). The PLS-ME (partial least squares path model) model further demonstrated a significant direct effect of the soil physicochemical parameters on the nitrogen cycling functional genes.DiscussionAs a result, the composition and diversity of the bacterial community and the nitrogen cycle functional genes in Cr–stressed agricultural soils changed considerably. However, the influence of the soil physicochemical parameters on the functional genes involved in the nitrogen cycle was greater than that of the bacterial community. and Cr stress affects the N cycling process in soil mainly by affecting nitrification. This research has significant practical ramifications for understanding the mechanisms of microbial community homeostasis maintenance, nitrogen cycle response mechanisms, and soil remediation in heavy metal–contaminated agricultural soils.
PASSED: Brain atrophy in non-demented individuals in a long-term longitudinal study from two independent cohorts
Authors: Haas Anna-Lena , Olm Pauline , Utz Janine , Siegmann Eva-Maria , Spitzer Philipp , Florvaag Anna , Schmidt Manuel Alexander , Doerfler Arnd , Lewczuk Piotr , Kornhuber Johannes , Maler Juan Manuel , Oberstein Timo Jan ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: February 2023

IntroductionAlzheimer’s disease (AD) is indicated by a decrease in amyloid beta 42 (Aβ42) level or the Aβ42/Aβ40 ratio, and by increased levels of Tau with phosphorylated threonine at position 181 (pTau181) in cerebrospinal fluid (CSF) years before the onset of clinical symptoms. However, once only pTau181 is increased, cognitive decline in individuals with subjective or mild cognitive impairment is slowed compared to individuals with AD. Instead of a decrease in Aβ42 levels, an increase in Aβ42 was observed in these individuals, leading to the proposal to refer to them as nondemented subjects with increased pTau-levels and Aβ surge with subtle cognitive deterioration (PASSED). In this study, we determined the longitudinal atrophy rates of AD, PASSED, and Biomarker-negative nondemented individuals of two independent cohorts to determine whether these groups can be distinguished by their longitudinal atrophy patterns or rates.MethodsDepending on their CSF-levels of pTau 181 (T), total Tau (tTau, N), Aβ42 or ratio of Aβ42/Aβ40 (A), 185 non-demented subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and 62 non-demented subjects from Erlangen AD cohort were assigned to an ATN group (A–T–N–, A–T+N±, A+T–N±and A+T+N±) and underwent T1-weighted structural magnetic resonance imaging (sMRI). Longitudinal grey matter (GM) atrophy patterns were assessed with voxel-based morphometry (VBM) using the cat12 toolbox on spm12 (statistical parametric mapping) of MRI scans from individuals in the ADNI cohort with a mean follow-up of 2 and 5 years, respectively. The annualized atrophy rate for individuals in the Erlangen cohort was determined using region of interest analysis (ROI) in terms of a confirmatory analysis.ResultsIn the A–T+N± group, VBM did not identify any brain region that showed greater longitudinal atrophy than the A+T+N±, A+T+N± or biomarker negative control group. In contrast, marked longitudinal atrophy in the temporal lobe was evident in the A+T–N± group compared with A+T–N±  and biomarker-negative subjects. The ROI in the angular gyrus identified by VBM analysis of the ADNI cohort did not discriminate better than the hippocampal volume and atrophy rate between AD and PASSED in the confirmatory analysis.DiscussionIn this study, nondemented subjects with PASSED did not show a unique longitudinal atrophy pattern in comparison to nondemented subjects with AD. The nonsignificant atrophy rate compared with controls suggests that increased pTau181-levels without concomitant amyloidopathy did not indicate a neurodegenerative disorder.
Kohonen neural network and symbiotic-organism search algorithm for intrusion detection of network viruses
Authors: Zhou Guo , Miao Fahui , Tang Zhonghua , Zhou Yongquan , Luo Qifang 
Published: February 2023

IntroductionThe development of the Internet has made life much more convenient, but forms of network intrusion have become increasingly diversified and the threats to network security are becoming much more serious. Therefore, research into intrusion detection has become very important for network security.MethodsIn this paper, a clustering algorithm based on the symbiotic-organism search (SOS) algorithm and a Kohonen neural network is proposed.ResultsThe clustering accuracy of the Kohonen neural network is improved by using the SOS algorithm to optimize the weights in the Kohonen neural network.DiscussionOur approach was verified with the KDDCUP99 network intrusion data. The experimental results show that SOS-Kohonen can effectively detect intrusion. The detection rate was higher, and the false alarm rate was lower.