bluuebunny/crossref_metadata_2025_split huggingface dataset:
Response Characteristics of Multipole Sonic Log in Double Casing Strings
Authors: Rao Bo , Su Yuanda , Li Shengqing , Tang Xiaoming 
Published: January 2023

Abstract
The method of using multi-layer casing to achieve interlayer isolation in deep wells has become very common, and the demand for cementing quality evaluation in multi-layer casing wells is becoming more and more urgent. However, there is no effective method for evaluating the cementing quality in multi-layer cased wells, especially when the production (inner layer) casing is eccentric. In this paper, the multipole acoustic wavefield is calculated in the double-cased well with the inner casing being centered and eccentric based on the Bessel translation addition theorem, aiming to explore the feasibility of using multipole array acoustic logging for evaluating the cementation quality between the outer casing and the formation in the double-casing wells under complex well conditions. The calculation results show that the non-axisymmetric wave field excited by the multipole acoustic source is very complex, and there are coexistence of multipole modes and mutual coupling of guided waves when the inner casing is eccentric. In addition, the velocity dispersion curves of the outer Stoneley waves and the casing flexural waves are closely associated with the acoustic impedance of the medium filled in the Annulus between the outer casing and formation, which can be used to evaluate the cementation quality of the outer annulus, and this phenomenon is not affected by the position and size of the inner casing. The analysis results of this study verified the feasibility of using multipole acoustic logging for cement evaluation in double-casing wells.
The transformation of a student-led health clinic in rural Australia from a face-to-face service to a telehealth model: Evaluation of student and client experiences during a COVID 19 driven transition
Authors: Walker Clara , Forbes Roma , Osborn Dayle , Lewis Peter A , Cottrell Neil , Peek Sam , Argus Geoff 
Published: January 2023

Introduction: The COVID-19 pandemic has necessitated the rapid transition of many face-to-face health services to alternate modes of service delivery. The objective of this study was to explore the benefits, challenges and perceived quality of a telehealth service delivery model from the perspective of clients and students. Further, students’ perceptions relating to the quality of the educational experience were also explored.
Methods: The study was set in a student-led interprofessional health and wellness clinic in rural Queensland, Australia. A qualitative case study design was used, including semi-structured student interviews and client open-response survey data. Participants were nursing and allied health students who completed a student-led interprofessional clinic placement and adults with low to rising risk of chronic disease who attended the clinic for telehealth delivered services.
Results: Themes identified following analysis included: new or adapted skills needed for success; challenges, limitations and the need for resources, training and support; quality interprofessional education experiences can be achieved in telehealth; coming away with a new set of skills; the important role of the client for success; and benefits and disadvantages of telehealth for clients.
Conclusions: The findings support that telehealth-based service-learning models are a feasible way to deliver health and wellness services from the perspective of students and clients and provide students with important skills for rural health service delivery.
Impact of cognitive impairment on clinical outcomes in elderly patients with atrial fibrillation: ANAFIE Registry
Authors: Nagata Ken , Inoue Hiroshi , Yamashita Takeshi , Akao Masaharu , Atarashi Hirotsugu , Ikeda Takanori , Koretsune Yukihiro , Okumura Ken , Shimizu Wataru , Suzuki Shinya , Tsutsui Hiroyuki , Toyoda Kazunori , Hirayama Atsushi , Yamaguchi Takenori , Teramukai Satoshi , Kimura Tetsuya , Morishima Yoshiyuki , Takita Atsushi , Yasaka Masahiro 
Published: January 2023

BackgroundThis subcohort study of All Nippon AF In the Elderly (ANAFIE) Registry based on 33 275 elderly patients (aged ≥75 years) with non-valvular atrial fibrillation (NVAF) investigated the relationship between cognitive function and 2-year clinical outcomes.MethodsA total of 2963 (mean age, 81.4 years) patients participated in this subcohort study and were classified as having normal cognition (Mini-Mental State Examination (MMSE) score ≥24/30) or cognitive impairment (score ≤23/30) at baseline. Patients with a decrease of >2 points after 24 months were classified as having cognitive decline.ResultsAt baseline, 586 (19.8%) patients had cognitive impairment. These patients tended to be older and had poorer general conditions than patients with normal cognition. The 2-year probability of stroke/systemic embolic events (SEEs), major bleeding and intracranial haemorrhage was numerically higher; those of cardiovascular death, all-cause death and net clinical outcome (composite of stroke/SEE, major bleeding and all-cause death) were significantly higher (all p<0.001) in patients with cognitive impairment versus normal cognition. In multivariate analysis, the risks of cardiovascular death (p=0.021), all-cause death (p<0.001) and net clinical outcome (p<0.001) were higher in patients with cognitive impairment versus those with normal cognition. After 24 months, 642 of 1915 (33.5%) patients with repeated MMSE determination had cognitive decline. Educational background <9 years, older age and concomitant cerebrovascular disorders were significant risk factors of cognitive decline at the 2-year follow-up.ConclusionsElderly patients with NVAF with cognitive impairment have a higher mortality risk than those with normal cognition. Several significant risk factors of cognitive decline were identified at 2-year follow-up.Trial registration numberUMIN000024006 (http://www.umin.ac.jp/).
Decreased capsaicin cough reflex sensitivity predicts hospitalisation due to COPD
Authors: Kanemitsu Yoshihiro , Kurokawa Ryota , Akamatsu Taisuke , Fukumitsu Kensuke , Fukuda Satoshi , Ito Yutaka , Takeda Norihisa , Nishiyama Hirono , Ito Keima , Tajiri Tomoko , Mori Yuta , Uemura Takehiro , Ohkubo Hirotsugu , Takemura Masaya , Maeno Ken , Oguri Tetsuya , Shirai Toshihiro , Niimi Akio 
Published: January 2023

IntroductionPatients with chronic obstructive pulmonary disease (COPD) are often hospitalised due to severe acute exacerbation (AE) or community-acquired pneumonia (CAP). Previous studies revealed the association of cough reflex sensitivity with the pathophysiology of COPD and pneumonia. We hypothesised that cough reflex sensitivity may be associated with severe AE or CAP requiring hospitalisation in patients with COPD.MethodsWe prospectively recruited 68 patients with COPD between June 2018 and January 2020. Patient characteristics, lung and cardiac functions, and biomarkers, including capsaicin cough reflex sensitivity and blood eosinophil count, were evaluated at enrolment. All participants were monitored for AE or CAP requiring hospitalisation for 12 months. We determined the risk factors and ORs for hospitalisation in patients with COPD using a multivariate analysis.ResultsEight patients experienced AE (n=3) or CAP (n=5) and required hospitalisation during follow-up. Patients in the hospitalisation+ group had higher modified Medical Research Council scores and blood eosinophil counts (≥300 µL) than those in the hospitalisation− group. Capsaicin cough reflex sensitivity tended to decrease in the hospitalisation+ group compared with that in the hospitalisation− group. Multivariate analysis revealed that a decreased capsaicin cough reflex and high eosinophil count (≥300 µL) were predictive risk factors for future hospitalisation due to AE-COPD or CAP.ConclusionIn addition to eosinophils, decreased capsaicin cough reflex sensitivity was associated with hospitalisation due to AE-COPD or CAP. Capsaicin cough reflex sensitivity in patients with COPD may play a role in the prevention of severe AE or pneumonia requiring hospitalisation.Trial registration numberUMIN000032497.
Primary salivary duct carcinoma of the lung: clinicopathological features, diagnosis and practical challenges
Authors: Li Shaoling , Hou Likun , Huang Yan , Wu Wei , Wu Chunyan , Zhang Liping 
Published: January 2023

AimsTo investigate the clinicopathological features, molecular characteristics and diagnostic criteria of primary salivary duct carcinoma of the lung (LSDC).MethodsWe analysed the clinicopathological and molecular features of five cases of LSDC retrieved from the archives of Shanghai Pulmonary Hospital from 2020 to 2022, and reviewed the relevant literature.ResultsAll patients were men, with an average age of 66 years (age range: 49–79 years), and all lesions were central masses with a mean maximum diameter of 42.6 mm (range: 16–70 mm). Morphologically, LSDC comprised of intraductal and invasive components. Both the intraductal and invasive components of LSDC can exhibit papillary, micropapillary, cribriform, tubule structures and solid proliferation. The intraductal component can exhibit Roman bridge structures, which were usually accompanied by central comedo-like necrosis. Immunohistochemically, LSDCs consistently expressed cytokeratin (CK)7 (5 of 5) and showed variable positivity of androgen receptor (AR) (5 of 5) focally or diffusely; additionally, the tumour cells expressed human epidermal growth factor receptor 2 (HER2) (3+, n=3; 2+, n=2), GATA-binding protein 3 (3 of 5), and gross cystic disease fluid protein-15 (1 of 5), and all of which were negative for thyroid transcription factor-1, napsin A, p40, CK5/6 and p63. The residual basal/myoepithelial cells surrounding the in situ carcinoma expressed p40, CK5/6 and p63. TP53 mutation and HER2 gene amplification (3 of 5) were the most frequent genetic alterations in LSDC. All patients who underwent surgical lobectomies were alive without recurrence or metastasis.ConclusionsLSDC is a highly rare malignant tumour. The distinctive architecture of in situ carcinoma and tumour cells expressing AR can provide diagnostic indications for LSDC.
Effectiveness of an outpatient rehabilitation programme in patients with neuralgic amyotrophy and scapular dyskinesia: a randomised controlled trial
Authors: Janssen Renske M J , Lustenhouwer Renee , Cup Edith H C , van Alfen Nens , Ijspeert Jos , Helmich Rick C , Cameron Ian G M , Geurts Alexander C H , van Engelen Baziel G M , Graff Maud J L , Groothuis Jan T 
Published: January 2023

BackgroundNeuralgic amyotrophy (NA) is an acute inflammation of nerves within the brachial plexus territory leading to severe pain and multifocal paresis resulting in >60% of patients having residual complaints and functional limitations correlated with scapular dyskinesia. Our primary aim was to compare the effects of multidisciplinary rehabilitation (MR), focused on motor relearning to improve scapular dyskinesia and self-management strategies for reducing pain and fatigue, with usual care (UC) on shoulder, arm and hand functional capability in patients with NA.MethodsIn a non-blinded randomised controlled trial (RCT), patients with NA (aged≥18 years, scapular dyskinesia, >8 weeks after onset) were randomised to either an MR or an UC group. MR consisted of a diagnostic multidisciplinary consultation and eight sessions of physical and occupational therapy. Primary outcome was functional capability of the shoulder, arm and hand assessed with the Shoulder Rating Questionnaire–Dutch Language Version (SRQ-DLV).ResultsWe included 47 patients with NA; due to drop-out, there were 22 participants in MR and 15 in UC for primary analysis. The mean group difference adjusted for sex, age and SRQ-DLV baseline score was 8.60 (95%CI: 0.26 to 16.94, p=0.044). The proportion attaining a minimal clinically relevant SRQ-DLV improvement (≥12) was larger for the MR group (59%) than the UC group (33%) with a number needed to treat of 4.ConclusionThis RCT shows that an MR programme focused on motor relearning to improve scapular dyskinesia, combined with self-management strategies for reducing pain and fatigue, shows more beneficial effects on shoulder, arm and hand functional capability than UC in patients with NA.Trial registration numberNCT03441347.
Health check-ups as interventions for work disability management: supervisors and occupational healthcare follow the recommendations to a great extent
Authors: Kuronen Jarmo , Winell Klas , Kopra Juho , Räsänen Kimmo 
Published: January 2023

ObjectivesWork disability management is a problem globally. This study was designed to find out whether the initiation, process and outcome of health check-ups (HCUs) follow the national legislation and whether supervisors and occupational healthcare (OHC) units act according to the legislation-based recommendations.MethodsData of 1092 employees with reduced work ability were collected during 2013–2018 in 15 OHC units across Finland. Nine reasons for HCUs, eight process activities and three recommendations were analysed. Cross-tabulation and multinomial logistic regression analysis were used in the analyses.ResultsEmployees themselves initiated an HCU for early support more often (OR with 95% CI 2.37; 1.04 to 5.40) compared with supervisors. Personnel in OHC units initiated an HCU in musculoskeletal disorders more often (OR 1.58; 95% CI 1.05 to 2.37) and in mental disorders less often (OR 0.52; 95% CI 0.35 to 0.76) compared with supervisors. These findings were reflected in the recommendations after the HCU, where rehabilitation was recommended for employees with musculoskeletal disorders more often than for employees with mental disorders (ORs 5.48; 95% CI 1.91 to 15.67 and 1.59; 95% CI 0.74 to 3.43, respectively).ConclusionSupervisors and OHC units followed the recommendations for management of work disability to a great extent. Employees were active in looking for help early when they had problems with work ability. This positive finding should be promoted even more. OHC units did not initiate HCUs or recommend rehabilitation in mental disorders as actively as they did in musculoskeletal disorders. Support of employees with mental disorders should be improved and studied more.Registration of the studyThe study protocol was approved and registered on 22 September 2017 by the Doctoral Program of Health Sciences, Faculty of Medicine, University of Eastern Finland, registration no. 189067.
Raising the bar on fibrinogen: a retrospective assessment of critical hypofibrinogenemia in severely injured trauma patients
Authors: Richards Justin , Fedeles Benjamin T , Chow Jonathan H , Scalea Thomas , Kozar Rosemary 
Published: January 2023

ObjectivesFibrinogen depletion may occur at higher levels than historically referenced. We evaluated hypofibrinogenemia and associated mortality and multiple organ failure (MOF) after severe injury.MethodsRetrospective investigation including 417 adult patients with Injury Severity Score (ISS) >15. Demographics and injury characteristics were collected. Fibrinogen within 30 minutes of admission was described: <150 mg/dL, 150 mg/dL to 200 mg/dL and >200 mg/dL. Primary outcome: 28-day mortality. Secondary outcomes: 28-day MOF and blood product transfusion. Multivariable logistic regression model evaluated association of fibrinogen categories on risk of death, after controlling for confounding variables. Results presented as OR and 95% CIs.ResultsFibrinogen <150 mg/dL: 4.8%, 150 mg/dL to 200 mg/dL: 18.2%, >200 mg/dL: 77.0%. 28-day mortality: 15.6%. Patients with <150 mg/dL fibrinogen had over fourfold increased 28-day mortality risk (OR: 4.9, 95% CI 1.53 to 15.7) after adjusting for age, ISS and admission Glasgow Coma Scale. Patients with lower fibrinogen were more likely to develop MOF (p=0.04) and receive larger red blood cell transfusion volumes at 3 hours and 24 hours (p<0.01).ConclusionsFibrinogen <150 mg/dL is significantly associated with increased 28-day mortality. Patients with fibrinogen <150 mg/dL were more likely to develop MOF and required increased administration of blood products. The optimal threshold for critically low fibrinogen, the association with MOF and subsequent fibrinogen replacement requires further investigation.Level of evidenceLevel III
Ovule abortion and seed set of field pea (Pisum sativum L.) grown under high temperature
Authors: Osorio Evelyn , Davis Arthur R. , Warkentin Thomas D. , Bueckert Rosalind A. 
Published: January 2023

In pea, high temperatures during reproductive development lead to severe yield loss. Although the ovule is the seed precursor, studies elucidating the effect of heat on this plant structure are scarce. We investigated the impact of heat in the field and growth chamber on ovules 4 days after the open flower (4DOF) stage. Objectives were to identify associations between ovaries and plant performance, and to evaluate seed set and ovule abortion of heat-treated plants for six cultivars from a diverse range of seed-to-ovule ratios. In the field, plants were seeded at early (control, [early seeded pea, ESP]) and late (stress plant [late seeded pea, LSP]) periods in the season. In growth chambers, plants were exposed to heat (35/18 °C) at early flowering for 4 days and then evaluated at maturity. Stressed plants (LSP) displayed twice as many aborted ovules than ESP during early embryo growth (pro-embryo to globular stage) in synchrony with reduced ovaries, ovules, and embryo sac size. Cultivars with reduced ovary size at 4DOF were related to a high number of reproductive nodes and pods in LSP ( r = −0.44 to −0.48). Similarly, under growth chamber conditions, heat caused seed reduction by increasing the abortion of immature ovules (early embryonic stages) at various reproductive nodes. Collectively, our results indicated that pea seed loss from heat in the field is largely due to early embryo abortion, a novel finding, rather than disruption of pre-fertilization events. Compensatory effects on plant performance infer plant resource adjustment. Our findings contribute to the assessment and selection of high-yielding pea cultivars for future warming seasons.
Constant-roll inflation field with Tsallis entopic proposal
Authors: Keskin A. I. , Kurt K. 
Published: January 2023

AbstractIn this work, we investigate the high-energy era of the universe from the constant-roll condition perspective by taking the Friedmann equation, which is modified by a non-additive Tsallis entropic proposal. In the framework of the observational data, we determine the constant-roll parameter. Under the fixed field condition of the constant-roll parameter, for the wide range of the power-term of the chaotic potentials, $$\sim \phi ^{n}$$

∼

ϕ
n

, which involves some string-chaotic potential models, $$n=\frac{2}{3}$$

n
=

2
3

, $$n=\frac{4}{5}$$

n
=

4
5

, the non-additive (nonextensive) Tsallis parameter is analyzed graphically. The resulting analysis shows that, in addition to a quasi-de Sitter phase, any value of the range $$0.5<n<1.2$$

0.5
<
n
<
1.2

points to a dynamical form of the dark energy (quintessence) in the early universe. It implies that n values in the range may be included in string-chaotic potential models. The non-additive Tsallis parameter provides this with the help of its negative values in the constant-roll field.
The seventh cervical vertebra is an appropriate landmark for thoracic kyphosis measures using distance from the wall
Authors: Wiyanad Arpassanan , Amatachaya Sugalya , Amatachaya Pipatana , Suwannarat Patcharawan , Chokphukiao Pakwipa , Sooknuan Thanat , Gaogasigam Chitanongk 
Published: January 2023

Background: Hyperkyphosis is frequently found nowadays due to the change in current lifestyles and age-related system decline. A simple hyperkyphosis measurement can be made easily using the perpendicular distance from the landmark to the wall. However, the existing evidence applied two different landmarks [occiput and the seventh cervical vertebra (C7)] and the measurement using rulers was susceptible to error due to their misalignment. Objective: To assess an appropriate landmark for thoracic kyphosis measurement using distance from the wall (KMD), by comparing between occiput and C7, as measured using rulers and verified using data from a specially developed machine, the so-called infrared-gun kyphosis wall distance tool (IG-KypDisT), and the Cobb angles. Methods: Community-dwelling individuals with a risk of thoracic hyperkyphosis (age [Formula: see text] years, [Formula: see text]) were cross-sectionally assessed for their thoracic hyperkyphosis using the perpendicular distance from the landmarks, occiput and C7, to the wall using rulers and IG-KypDisT. Then the Cobb angles of these participants were measured within seven days. Results: The outcomes from both landmarks differed by approximately 0.8[Formula: see text]cm ([Formula: see text] 0.084). The outcomes derived from C7 were more reliable (ICCs[Formula: see text]0.93, [Formula: see text]0.001), with greater concurrent validity with the radiologic data ([Formula: see text] 0.738, [Formula: see text]0.001), with the overall variance predicted by the regression models for the Cobb angles being higher than that from the occiput (47–48% from C7 and 38–39% from occiput). The outcomes derived from rulers and IG-KypDisT showed no significant differences. Conclusion: The present findings support the reliability and validity of KMD assessments at C7 using rulers as a simple standard measure of thoracic hyperkyphosis that can be used in various clinical, community, and research settings.
Mechanical Dyssynchrony of Isolated Left and Right Ventricular Human Myocardium in End-Stage Heart Failure
Authors: Mashali Mohammed A. , Saad Nancy S. , Peczkowski Kyra K. , Fanning Tom , Hare Austin N. , Whitson Bryan A. , Mokadam Nahush A. , Janssen Paul M.L. 
Published: January 2023

Background:
The left and right ventricles of the human heart differ in embryology, shape, thickness, and function. Ventricular dyssynchrony often occurs in cases of heart failure. Our objectives were to assess whether differences in contractile properties exist between the left and right ventricles and to evaluate signs of left/right ventricular mechanical synchrony in isolated healthy and diseased human myocardium.

Methods:
Myocardial left and right ventricular trabeculae were dissected from nonfailing and end-stage failing human hearts. Baseline contractile force and contraction/relaxation kinetics of the left ventricle were compared to those of the right ventricle in the nonfailing group (n=41) and in the failing group (n=29). Correlation analysis was performed to assess the mechanical synchrony between left and right ventricular myocardium isolated from the same heart, in nonfailing (n=41) and failing hearts (n=29).

Results:

The failing right ventricular myocardium showed significantly higher developed force (Fdev;
P
=0.001; d=0.98), prolonged time to peak (
P
<0.001; d=1.14), and higher rate of force development (
P
=0.002; d=0.89) and force decline (
P
=0.003; d=0.82) compared to corresponding left ventricular myocardium. In healthy myocardium, a strong positive relationship was present between the left and right ventricles in time to peak (r=0.58,
P
<0.001) and maximal kinetic rate of contraction (r=0.63,
P
<0.001). These coefficients were much weaker, often nearly absent, in failing myocardium.

Conclusions:
At the level of isolated cardiac trabeculae, contractile performance, specifically of contractile kinetics, is correlated in the nonfailing myocardium between the left and right ventricles‚ but this correlation is significantly weaker, or even absent, in end-stage heart failure, suggesting an interventricular mechanical dyssynchrony.