bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influencing factors of Susceptibility Vessel Sign on Susceptibility-Weighted Magnetic Resonance Imaging in patients with acute ischemic stroke
Authors: Jiang Han , Li Ziqiang , Gao Haiyan , Shen Yu , Wei Wei , Bai Yan , Zhang Xianchang , Wang Meiyun 
Published: February 2023

Abstract
Objective: The presence of acute susceptibility vessel sign (SVS) in anterior circulation occlusive stroke reflects the presence of deoxyhemoglobin in the thrombus and the thrombus composition may change with time. The purpose of this study was to investigate the related factors affecting SVS.
Material and methods: We retrospectively analyzed the data of 161 patients with acute stroke who underwent middle cerebral artery occlusion and magnetic resonance imaging (MRI) examination from July 16, 2020, to June 24, 2022. These patients all contained readable susceptibility-weighted imaging (SWI) information. The characteristics of the patients were compared according to the presence or absence of SVS. Univariate statistical analysis was performed, and then meaningful variables from the univariate statistical analysis were included in the multivariate statistical analysis.
Results: Of the 161 patients included in the study, 109 (67.7%) were in the SVS+ group. SVS+ was significantly correlated with age (P=0.031), cardiogenic stroke subtype (P=0.028), and the combination of atrial fibrillation/flutter (P =0.002). Multivariate analysis showed that combined atrial fibrillation/flutter was an independent risk factor for SVS+ (OR, 4.517; 95% CI, 1.324–15.413; P =0.016). There was no significant relationship between SVS+ and symptom onset -- imaging time.
Conclusion: In the acute phase of proximal middle cerebral artery occlusive stroke, atrial fibrillation/flutter was an independent risk factor for SVS positivity. For patients with known symptom onset time, SVS was not significantly associated with symptom onset -- imaging time.
Anlotinib inhibits the development of esophageal squamous cell carcinoma by regulating the PI3K/AKT signaling pathway
Authors: Ji Shanshan , Wu Hongjiao , Li Ang , Xie Yuning , Hu Wenqian , Song Qinqin , Liu Jiawei , Zhang Xuemei , Zhang Zhi 
Published: February 2023

Abstract
Background: Anlotinib, a small molecule multi-targeted tyrosine kinase inhibitor, is widely used in the treatment of various diseases. This study aimed to investigate the potential therapeutic effects and possible molecular mechanisms of anlotinib on esophageal squamous cell carcinoma (ESCC) .
Methods: Cell viability was detected by CCK-8 assay. Wound-healing and transwell assay were used to evaluate the migratory-invasive ability of ESCC cells. Apoptosis was detected by Hoechst33342 fluorescence staining. Transcript data were obtained by RNA sequencing. Transcript data were analyzed for differentially expressed genes (DEGs) using the DESeq2 program. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed using R package clusterProfiler. Western blotting was used to detect the protein expression level.
Results: The results of functional experiments showed that anlotinib can inhibit the viability of KYSE30 cells with time- and dose-dependent toxicity. The IC50 at 24h, 48h and 72h were 124.85μM, 21.226μM and 13.03μM, respectively. Anlotinib also inhibited cell migration and invasion, and induced apoptosis. Transcriptome sequencing results showed that anlotinib resulted in 359 genes were up-regulated and 156 down-regulated in KYSE30 cells. GO analysis of these DEGs showed that GO mainly included biological processes and molecular functions. KEGG enrichment analysis showed that PI3K/AKT pathway was the most critical signaling pathway. Western blot demonstrated that anlotinib inhibited the phosphorylation of AKT, and the total protein expression of PI3K and AKT.
Conclusion: Anlotinib inhibits the progression of ESCC cells by modulating the PI3K/AKT signaling pathway.
Time Flies, but You’re in Control: the Mediating Effect of Self-control between Time Attitude and Academic Procrastination
Authors: Wang Juanjuan , Sun Yi 
Published: February 2023

Abstract
A holiday is a time of rest. However, the abrupt lifting of lockdowns in China made middle schools postpone their final exams to the end of the winter holiday. Chinese middle school students experienced an unprecedented holiday, in which they struggled between procrastinating and sticking to the review plan. This study thus investigated their academic procrastination within this extraordinary context. Prior studies also suggested the correlation among academic procrastination, time attitude and self-control. Therefore, we expected a mediating effect of self-control on the relationship between procrastination and time attitude. Initially, we used a questionnaire survey to obtain students’ self-reported data on procrastination, time attitude and self-control. Then, we implemented a case study to check students’ completion of the review plan in real settings. The results of both the survey and the case study indicated that Chinese middle school students demonstrated a greater tendency for academic procrastination. Additionally, self-control negatively correlated with academic procrastination, and self-control significantly mediated the relationship between academic procrastination and positive time attitudes. This study enriches the existing research with data from a novel situation, and supplies empirical evidence for teaching regulation and intervention.
Knowledge and Attitudes of Chinese Medical Researchers Toward Electronic Informed Consent in Clinical Research: A Cross-sectional Study
Authors: Liu Xing , Tan Xin , Wu Ying , Zhong Yuqiong , Khoshnood Kaveh , Wang Xiaomin 
Published: February 2023

Abstract
Background: The use of electronic informed consent (eIC) in clinical research is trending in China. Nevertheless, even as Chinese medical researchers implement eIC, little is known about their knowledge of the technology or their perspectives on its use. Ours is the first study to assess the knowledge and attitudes of medical researchers toward eIC in clinical research in China. This study aims to better advance the application and development of eIC in clinical research in China.
Methods: A cross-sectional survey was conducted. Using stratified random sampling, we recruited medical researchers from six provincial hospitals and two municipal hospitals in Hunan Province, Central Southern China. We used a self-adapted questionnaire to examine the researchers’ knowledge about and attitudes toward eIC.
Results: Three hundred ninety-nine questionnaires were included in the analysis. Most medical researchers (67.9%) had learned about eIC through the research department within a hospital, and 74.9% had heard of the term “electronic informed consent.” We found that 61.9% of these respondents had not used eIC. Regarding their overall attitude toward eIC, most respondents (69%) preferred eIC to paper-based consent. Of the respondents, 81.7% said eIC was more convenient than paper-based consent, 79.7% thought it was more efficient than paper-based consent, and more than half (51.1%) thought eIC could completely replace paper-based consent. However, 60.7% of participants expressed concerns about its security and confidentiality, and 87.5% thought eIC should include more detailed confidentiality instructions. In addition, 47.4% expressed concerns about the legal effectiveness and medical researchers’ rights protections provided by eIC, and 89.7% believed that laws and regulations related to eIC need improvement.
Conclusion: Medical researchers generally have a high level of knowledge about eIC and a positive attitude toward its use. However, they have concerns about data security and privacy protection that need to be addressed. More than half of medical researchers believe that eIC can totally replace paper-based consent. Moreover, most participants would like more specific guidance on eIC implementation.
Polyautoimmunity with Polymyositis, Uveitis, and Progressive Cutaneous Depigmentation in a Mixed Breed Dog: A Case Report
Authors: Lee Mary Ann , Hulsebosch Sean E , Affolter Verena K , Dear Jonathan D , Knipe Marguerite F , Maggs David J , Moore Bret A , Outerbridge Catherine A , Marsilio Sina 
Published: February 2023

Abstract
Background:Polyautoimmunity is the expression of more than one autoimmune disease in a single patient. This report documents polyautoimmunity in a mixed breed dog with concurrent uveitis, cutaneous depigmentation, and polymyositis.
Case presentation: A 1-year-old male neutered mixed breed dog was presented for progressive generalized leukotrichia and leukoderma, bilateral panuveitis, and masticatory muscle atrophy. The latter progressed to myositis of lingual, pharyngeal, and masticatory muscles confirmed by biopsy. Temporalis muscle was completely replaced by adipose and fibrous tissue, and necrotic myofibers with extensive infiltration of mononuclear cells indicated active myositis of lingual muscle. Skin biopsies showed severe melanin clumping in epidermis, hair follicles, and hair shafts, and perifollicular pigmentary incontinence. Uveitis, depigmentation, and polymyositis were diagnosed based on clinical, histological, and laboratory findings.
Conclusions:To the authors’ knowledge, this is the first report of concurrent uveitis, progressive cutaneous depigmentation, and polymyositis involving the masticatory muscles in a dog.
Trans Sellar‐ Trans Sphenoidal Encephalocele Presenting as Nasal Obstruction in an Infant: a Rare Case Report
Authors: Basheer Noufal , Raj Aiswarya , Mathew Jim , Alapatt Jacob 
Published: February 2023

Abstract
Trans sellar trans sphenoidal encephalocele is a rare congenital anomaly, with only around 10 cases having been documented in literature around the world. Surgical repair of these defects in the pediatric population commonly uses either the trans cranial or the trans palatal approach, with the choice of approach being individualized based on the clinical features, age, and associated defects present in the patient. Here we document a case of a 4-month-old child who presented to us with nasal obstruction, who was diagnosed with this rare entity and successfully underwent a transcranial repair for the same.,
RSDFT-NEGF transport simulations in realistic nanoscale transistors
Authors: Mil'nikov Gennady , Iwata Jun-ichi , Mori Nobuya , Oshiyama Atsushi 
Published: February 2023

Abstract
The paper presents a device simulator for computing transport characteristics from first principles. The developed computer program effectively performs large-scale parallel calculation of quasi-one-dimensional quantum transport in realistic nanoscale devices with thousands of atoms in the cross section area of the device channel. Our simulator is based on the real-space Kohn-Sham Hamiltonian in the density functional theory and improved numerical algorithms for reducing computational burden in non-equilibrium Green's function (NEGF) method. Several computational improvements have been introduced in constructing a reduced quantum transport model from the original Kohn-Sham Hamiltonian and implementing the R-matrix computational scheme in the NEGF simulations.
PACS numbers: 72.10.Bg, 73.23.-b, 73.40.Qv
Asymmetric Bi-directional Teleportation Scheme in the presence of a Mentor and a Controller
Authors: Mandal Manoj Kumar , Choudhury Binayak S. , Samanta Soumen 
Published: February 2023

Abstract
In this paper a quantum communication protocol is proposed for the purpose of the exchange of a single qubit and a three-qubit state between two parties. It is a bi-directional teleportation protocol where the two parties have no information about the states they possess. The protocol has a Mentor who initiates the process and by measurement fixes the course of it amongst several possible alternatives. The participants are not initially connected through a single entangled state. It is the action of the Mentor which creates a seven-qubit entanglement amongst the legitimate parties. The role of the Mentor ends thereby. There is a Controller to oversee the process whose action leads to the completion of the protocol. The efficiency of the present protocol is calculated and it is found to be higher than several existing bi-directional protocols.
Assessment of selected muscle and intestinal damage markers after maximum-intensity exercise in men with type 1 diabetes treated with a personal insulin pump
Authors: Matejko Bartłomiej , Tota Łukasz , Morawska-Tota Małgorzata , Pałka Tomasz , Malecki Maciej , Klupa Tomasz 
Published: February 2023

Abstract
Purpose
Exercise-induced muscle damage depends on exercise intensity and duration and on individual susceptibility. Mechanical and metabolic stress may disturb the intestinal microflora. The study evaluated selected intestinal and muscle damage markers after maximum-intensity exercise in type 1 diabetes (T1D) men compared with healthy control.
Methods
The study involved 16 T1D participants and 28 controls matched by age (22.7 [21.3–25.1] vs. 22.6 [20.9–26.3] years), body mass index (24.2 ± 1.6 vs. 24.2 ± 1.9 kg/m2), and body fat percentage (16.1 ± 5.2 vs. 14.9 ± 4.6%). The T1D group have 11.3 ± 5.1 years of diabetes duration and a suboptimal mean glycated haemoglobin level of 7.2 ± 1.1%. The subjects underwent a graded running treadmill test until exhaustion. Lactate concentration was assessed in arterialized blood at baseline and 3 and 20 minutes after the test. Cortisol, testosterone, tumour necrosis factor α, myoglobin, lactate dehydrogenase, zonulin, and vitamin D levels were evaluated in cubital fossa vein blood before and 60 minutes after the test.
Results
T1D patients presented higher baseline zonulin, myoglobin concentration, testosterone/cortisol ratio, and lower maximal oxygen uptake. On adjusting for the baseline values, the groups differed in zonulin, lactate dehydrogenase, and myoglobin levels, testosterone/cortisol ratio, and lactate concentration determined 20 minutes after exercise (p < 0.05).
Conclusion
Maximum-intensity exercise increased muscle and intestinal damage in T1D participants. In patients with lower physical activity, very-high-intensity exercise should be recommended with caution. Observing the anabolic-catabolic index may help individualize effort intensity in T1D individuals.
Treatment with buprenorphine increased the expression of norepinephrine genes in the lumbar spinal cords of methamphetamine rats
Authors: Jajaei Nina , Nemati Homeira Hatami , Khakpay Roghaieh , Khajehnasiri Nazli , Sadeghian Reihaneh 
Published: February 2023

Abstract
Background METH damages neurons by releasing reactive oxygen species. Oxidative stress affects monoamine oxidase (MAO), a key enzyme in catecholamine oxidation. The pathogenesis of addiction may also be affected by MAO activity. Thus, the expression of MAO and norepinephrine (NE) genes was investigated in the lumbar spinal cord of METH rats during buprenorphine (PUB) treatment.
Methods and results Eleven groups of male Wistar rats (n=77) were randomly selected: control, METH (10 mg/kg; 5 days), BUP (6 or 10 mg/kg; for 5 or 14 days), BUP (6 or 10 mg/kg; for 5 or 14 days) + METH, and withdrawal syndrome for 72 hours after the last injection. After receiving treatments, the gene expression levels of MAO and NE using the real-time PCR method were assessed. METH chronically increased NE gene expression compared to the control group. The METH+ BUP (6 mg/kg; for 5 days) or METH+ BUP (10 mg/kg; for 14 days) groups increased the level of NE gene expression in comparison to the control group. The withdrawal group expressed less than the METH group. Conversely, there was no difference in MAO gene expression between groups.
Conclusion Based on the results, BUP increases neuronal health by modifying the expression of the NE gene, enabling it to reduce METH's harmful effects.
Mineralogy and geochemistry of the black shales from Wufeng-Longmaxi Formations(Late Ordovician-Early Silurian) in Xindi No. 1 well, Southwest of Sichuan Basin: Constraints on provenance, source area weathering and tectonic setting
Authors: Ge Xiangying , Mou Chuanlong , Men Xin , Yu Qian , Liu Wei , He Jianglin , Chen Feifei 
Published: February 2023

Abstract
The Late Ordovician-Early Silurian period witnessed the second largest Phanerozoic mass extinction, Hirnantian glaciation and volcanic events. Wufeng, Guanyinqiao and Longmaxi formations were developed in South China across the Ordovician-Silurian transition.To infer the weathering conditions, provenance, tectonic setting of the source area in western South China during this period, we measured the mineralogical and geochemical characteristics of 42 samples of Wufeng-Longmaxi formations taken from Xindi No. 1 well, south west of Sichuan Basin. These shales and argillaceous limestones mainly consist of quartz, clay mineral, carbonate, feldspar, and minor amounts of pyrite. Geochemically, the rocks from three formations are enriched in CaO and MgO and slightly depleted in SiO2, Al2O3 and K2O. Chondrite-normalized rare earth elements (REE) patterns display a negative Eu anomaly, a slight enrichment in LREE and a flat HREE. Paleoweathering indices (CIA and PIA) and Th/U ratios indicate that the sediments experienced moderate-intense to weak chemical weathering in the source area. CIA values of the lower Wufeng Formation range from 64.88 to 70.88, indicating a warm and humid climate. Upward the CIA values on the top of Wufeng Formation decrease from 62.56 to 62.93, the CIA values of the Guanyinqiao and lowest Longmaxi formation are consistently low values (58.48-67.12) , suggesting a cold and dry climate which is consistent with Gondwana glaciation in Hirnantian period. Geochemical discrimination diagrams revealed that the rocks of the three formations were derived from felsic igneous source rocks and deposited in an active continental margin setting.
Global Classical Solutions to the viscous two-phase flow model with slip Boundary Conditions in 3D Exterior Domains
Authors: Li Zilai , Liu Hao , Wang Huaqiao , Zhou Daoguo 
Published: February 2023

Abstract
We consider the two-phase flow model in 3D exterior domains with slip boundary conditions. We establish the global existence of classical solutions of this system provided that the initial energy is suitably small. Furthermore, we prove that the pressure has large oscillations and contains vacuum states when the initial pressure allows large oscillations and a vacuum. Finally, we also obtain the large-time behavior of the classical solutions.
2010 Mathematics Subject Classification. 35Q35; 35Q30; 35A09; 35B40.
Does green infrastructure work? Precipitation, protected areas, floods and landslides.
Authors: Robalino Juan , Mullan Katrina , Piaggio Matias , Guzman Marisol 
Published: February 2023

Abstract
We evaluate whether floods and landslides are more likely when rain falls inside versus outside protected areas (PAs). We use monthly municipality data for the period 2000–2015 in Guatemala and monthly district data for the period 1992–2019 in Costa Rica. We define relevant catchment areas using water flows to population centers of administrative units. Then, we calculate the precipitation inside and outside PAs within the relevant catchment areas, and test how the frequency of floods and landslides is affected by whether rain falls inside or outside PAs. We use a two-way fixed effect panel data model. For Guatemala, we find no robust statistically significant effects on these type of disasters. However, in Costa Rica, we find that shifts in precipitation towards PAs reduce floods significantly. These results were highly robust. We also find effects on landslides in densely populated districts, as well as reductions in flood-related deaths.
Early changes of cTnT and NT-proBNP in neonates underwent ECMO support: a single-center experience
Authors: Huang Jiang-Shan , zhou Si-Jia , Chen Xiu-Hua , Zheng Yi-Rong , Cao Hua , Chen Qiang 
Published: February 2023

Abstract

Objective:To explore the changes in the absolute value and decline rate of early serum cTnT and NT-proBNP in neonates who underwent V-A ECMO support therapy within one week of birth.Methods:Clinical data and laboratory test results of 17 neonates who underwent V-A ECMO support therapy within one week of birth from January 2020 to January 2023 were retrospectively collected from the electronic medical record system. The patients were divided into the survival group and the death group. The absolute values and decline rate of cTnT and NT-proBNP were compared between the two groups on the day, 24, 48, and 72 hours after ECMO treatment.Result:Of the 17 neonates, 10 survived, and 7 died, with a survival rate of 58.8%. The absolute values of cTnT and NT-proBNP in the survival group were significantly lower than those in the death group, and the decline rate was significantly higher than in the death group. In this study, neonates with no early decline in cTnT and NT-proBNP were all in the death group.Conclusion:The changes in the absolute value and decline rate of early serum cTnT and NT-proBNP in neonates who underwent V-A ECMO may predict their prognosis.
Prophylactic Abdominal Drainage After Gastrectomy: An Updated Meta-Analysis
Authors: Zhu Guangxu , Zhou Shengjie , Sun Qihang , Li Bowen , Zhu Qingshun , Jiao Xuguang , Zhai Shengyong , Xiong Jinqiu , Lang Xiaomin , Qu Jianjun 
Published: February 2023

Abstract
Introduction: At present, there is no convincing evidence-based medical basis for the placement of prophylactic drain after gastrectomy.This meta-analysis aimed to analyze the incidence of complications and the recovery of gastrointestinal function after gastrectomy in the drain group and the no-drain group.
Methods: Data were retrieved from electronic databases PubMed, EMBASE, Medline, Cochrane Library, CNKI, Wanfang and VIP databases up to December 2022, including the outcomes of individual treatment after gastrectomy. Complication related index:Incidence of Postoperative Complications, Anastomotic leak，Intra-abdominal bleeding, Wound Infection, Hospital mortality, Pulmonary infection, Intra-abdominal abscess, Abdominal infection, Readmission, Reoperation, Drain related complications etc. Recovery of gastrointestinal function related index: Passage of flatus, Initiation of soft diet, Hospital stay after surgery. The Jadad score and Newcastle-Ottawa scale were used to assess the quality of the included studies.
Results: After screening, 20 literatures were finally included, including 4984 patients. Meta-analysis results showed that the passage of flatus（WMD=0.32, 95%CI=0.07~0.58, P=0.01）and initiation of soft diet（WMD=0.45, 95%CI=0.20~0.71, P=0.0005）in the no-drain group were better than those in the drain group. The drain group was not superior to the no-drain group in hospital stay after surgery, postoperative complications, wound infection, pulmonary infection, anastomotic leakage, intra-abdominal abscess, intra-abdominal bleeding, intra-abdominal infection, mortality, reoperation, readmission, and drainage-related complications.
Conclusions: Prophylactic placement of the peritoneal drainage tube did not reduce the incidence of early complications but delayed recovery of gastrointestinal function. Abdominal drainage is not required after radical gastrectomy, but is recommended for high-risk patients with anastomotic fistula and intraperitoneal bleeding.