bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitrectomy with sulfur hexafluoride versus air tamponade for idiopathic macular hole: a retrospective study
Authors: Yao Yuou , Yan Huichao , Qu Jinfeng , Dong Chongya , Liang Jianhong , Yin Hong , Ren Chi , Jin Enzhong , Zhao Mingwei 
Published: July 2023

Abstract
Background
To evaluate the effect of room air and sulfur hexafluoride (SF6) gas in idiopathic macular hole(MH)surgery.

Methods
Retrospective, interventional, and comparative study. 238 eyes with the idiopathic macular hole that underwent pars plana vitrectomy, internal limiting membrane peeling, fluid-air exchange, and 20% SF6 (SF6 group:125 eyes) or room air tamponade (air group: 113 eyes) were reviewed. The primary outcome measure was the closure rate of primary surgery.

Results
The baseline characteristics of the SF6 group and air group were comparable except for the hole size (479.90 ± 204.48 vs. 429.38 ± 174.63 μm, P = 0.043). The anatomical closure rate was 92.8% (116 / 125) with the SF6 group and 76.1% (86 / 113) with the air group (P < 0.001). A cut-off value of MH size to predict primary anatomical closure was 520 μm, which is based on the lower limit of 95% confidential interval of the MH size among the unclosed patients in the air group. There was no significant difference in anatomical closure rates between SF6 and air group (98.7% vs. 91.9%, P = 0.051) for MH ≤ 520 μm, whereas a significantly lower anatomical closure rate was shown in the air group than SF6 group (46.2% vs. 84.0%, P < 0.001) for MH > 520 μm.

Conclusion
SF6 exhibited more effectiveness than air to achieve a good anatomical outcome for its longer tamponade when MH > 520 μm.
Eating disorders during the COVID-19 pandemic: scoping review of psychosocial impact
Authors: Maia Bruna Bortolozzi , de Oliveira-Cardoso Érika Arantes , dos Santos Manoel Antônio 
Published: July 2023

Abstract
Background
The outbreak of the COVID-19 pandemic in early 2020 drastically changed the daily lives of the entire population. Despite being efficient in helping to avoid deaths and prevent the collapse of the healthcare system, social distancing can lead to unfavorable outcomes in the physical and mental health of the population, in particular, those diagnosed with eating disorders. This scope review aimed to analyze the scientific production on the psychosocial impact of the COVID-19 pandemic on people with eating disorders, in the subtypes anorexia nervosa and bulimia.

Method
This is a scope review, based on a rigorous method based on the PRISMA strategy. The indexed databases PubMed, LILACS, PsycINFO, Web of Science, SciELO, CINHAL, and Embase were consulted. After screening 387 records, 19 studies were included in the review.

Results
The results were subdivided into four thematic categories: (1) repercussions of confinement on daily life, in which the impacts of social distancing on daily life are presented, such as greater contact with the family and sudden changes in routine; (2) impacts on the treatment performed for eating disorders, underlining the effects of discontinuity of face-to-face treatments; (3) consequences for mental health, highlighting the consequences of the uncertain period for psychological distress; and (4) effects on symptoms of eating disorders, emphasizing the consequences of the pandemic for the symptoms of anorexia and bulimia.

Conclusion
We concluded that the confinement and uncertainties of this period accentuated preexisting symptoms, arousing feelings of helplessness and loneliness, especially because they were patients who were more susceptible to routine changes and fragilization of social support networks. Strengthening the personal support network is especially important, as well as investing in strengthening the bond between family members and health services, which points to future research.
Evolutionary assessment of SQUAMOSA PROMOTER BINDING PROTEIN-LIKE genes in citrus relatives with a specific focus on flowering
Authors: Li Yawei , Wang Shuting , Adhikari Prakash Babu , Liu Bing , Liu Shengjun , Huang Yue , Hu Gang , Notaguchi Michitaka , Xu Qiang 
Published: July 2023

AbstractPhase transition and floral induction in citrus requires several years of juvenility after germination. Such a long period of juvenility has been a major hindrance to its genetic improvement program. Studies have shown that miR156 along with its downstream genes SQUAMOSA PROMOTER BINDING PROTEINS (SBP) and SBP-LIKE (SPL) mediate the phase transition and floral induction process in plants. Our current study has systematically analyzed SPLs in 15 different citrus-related species, systematically annotated them based on their close homology to their respective Arabidopsis orthologs, and confirmed the functional attributes of the selected members in floral precocity. The majority of the species harbored 15 SPLs. Their cis-element assessment suggested the involvement of the SPLs in diverse developmental and physiological processes in response to different biotic and abiotic cues. Among all, SPL5, SPL9, and SPL11 stood out as consistently differentially expressed SPLs in the adult and young tissues of different citrus-related species. Independent overexpression of their F. hindsii orthologs (FhSPL5, FhSPL9, and FhSPL11) brought an enhanced expression of endogenous FLOWERING LOCUS T leading to the significantly precocious flowering in transgenic Arabidopsis lines. Future study of the genes in the citrus plant itself is expected to conclude the assessments made in the current study.
Graphical Abstract
Solving a multi-objective solid transportation problem: a comparative study of alternative methods for decision-making
Authors: Abdelati Mohamed H. , Abd-El-Tawwab Ali M. , Ellimony Elsayed Elsayed M. , Rabie M 
Published: July 2023

AbstractThe transportation problem in operations research aims to minimize costs by optimizing the allocation of goods from multiple sources to destinations, considering supply, demand, and transportation constraints. This paper applies the multi-dimensional solid transportation problem approach to a private sector company in Egypt, aiming to determine the ideal allocation of their truck fleet.In order to provide decision-makers with a comprehensive set of options to reduce fuel consumption costs during transportation or minimize total transportation time, a multi-objective approach is employed. The study explores the best compromise solution by leveraging three multi-objective approaches: the Zimmermann Programming Technique, Global Criteria Method, and Minimum Distance Method. Optimal solutions are derived for time and fuel consumption objectives, offering decision-makers a broad range to make informed decisions for the company and the flexibility to adapt them as needed.Lingo codes are developed to facilitate the identification of the best compromise solution using different methods. Furthermore, non-dominated extreme points are established based on the weights assigned to the different objectives. This approach expands the potential ranges for enhancing the transfer problem, yielding more comprehensive solutions.This research contributes to the field by addressing the transportation problem practically and applying a multi-objective approach to support decision-making. The findings provide valuable insights for optimizing the distribution of the truck fleet, reducing fuel consumption costs, and improving overall transportation efficiency.
Characteristics of Transgender and Gender-Diverse Youth Presenting for Surgery in the United States
Authors: Uffman Joshua C. , Willer Brittany L. , Mpody Christian , Nafiu Olubukola O. , Tobias Joseph D. 
Published: July 2023

BACKGROUND:
The number of adolescents and adults identifying as trans or gender-diverse is increasing. The lesbian, gay, bisexual, transgender, queer, and “other” (LGBTQ+) population is recognized as a marginalized health care population. This retrospective study sought to investigate demographic trends in transgender and gender-diverse (TGD) youth accessing surgical care in the United States.

METHODS:
Using a multi-institutional dataset from the Pediatric Health Information System (PHIS), we described demographic and periprocedural data for TGD adolescents, ages 10 to 18 years, who underwent a surgical procedure between January 1, 2016 and August 31, 2022.

RESULTS:
Among 767,224 youth who underwent surgical procedures during the study period, 807 (0.1%, 95% confidence interval [CI], 0.09–0.11) were identified as TGD. The overall prevalence of identified TGD youth increased from 0.02% in 2016 to 0.23% in 2022. TGD youth were mostly (71%) assigned female at birth and 13 to 18 years of age (91%, 733/807) at the time of surgery. A total of 76% of TGD patients were non-Hispanic White, 62% had commercial insurance, and 49% lived in a ZIP code with a median annual income between $39,000 and $63,000. Of the 807 TGD patients identified, 264 (33%) were from the Northeast, 226 (28%) were from the Midwest, 219 (27%) were from the West, and 98 (12%) were from the South census regions. The most common procedures for TGD youth to undergo were breast reduction/augmentation (n = 135), insertion/removal of subcutaneous implant device (n = 98), and orthopedic procedures of the hip and lower extremity (n = 29).

CONCLUSIONS:
We reported the perioperative characteristics of TGD youth and showed a steady increase in the detected prevalence of TGD adolescents accessing surgical care. Future investigations into specific challenges associated with caring for these patients are warranted.
Evidence from the first Shared Medical Appointments (SMAs) randomised controlled trial in India: SMAs increase the satisfaction, knowledge, and medication compliance of patients with glaucoma
Authors: Sönmez Nazlı , Srinivasan Kavitha , Venkatesh Rengaraj , Buell Ryan W. , Ramdas Kamalini 
Published: July 2023

In Shared Medical Appointments (SMAs), patients with similar conditions meet the physician together and each receives one-on-one attention. SMAs can improve outcomes and physician productivity. Yet privacy concerns have stymied adoption. In physician-deprived nations, patients’ utility from improved access may outweigh their disutility from loss of privacy. Ours is to our knowledge the first SMA trial for any disease, in India, where doctors are scarce. In a 1,000-patient, single-site, randomized controlled trial at Aravind Eye Hospital, Pondicherry, we compared SMAs and one-on-one appointments, over four successive visits, for patients with glaucoma. We examined patients’ satisfaction, knowledge, intention-to-follow-up, follow-up rates, and medication compliance rates (primary outcomes) using intention-to-treat analysis. Of 1,034 patients invited between July 12, 2016 –July 19, 2018, 1,000 (96.7%) consented to participate, and were randomly assigned to either SMAs (NSMA = 500) or one-on-one appointments (N1-1 = 500). Patients who received SMAs showed higher satisfaction (MeanSMA = 4.955 (SD 0.241), Mean1-1 = 4.920 (SD 0.326); difference in means 0.035; 95% CI, 0.017–0.054, p = 0.0002) and knowledge (MeanSMA = 3.416 (SD 1.340), Mean1-1 = 3.267 (SD 1.492); difference in means 0.149; 95% CI, 0.057–0.241, p = 0.002) than patients who received one-on-one appointments. Across conditions, there was no difference in patients’ intention-to-follow-up (MeanSMA = 4.989 (SD 0.118), Mean1-1 = 4.986 (SD 0.149); difference in means 0.003; 95% CI, -0.006–0.012, p = 0.481) and actual follow-up rates (MeanSMA = 87.5% (SD 0.372), Mean1-1 = 88.7% (SD 0.338); difference in means -0.012; 95% CI, -0.039–0.015, p = 0.377). Patients who received SMAs exhibited higher medication compliance rates (MeanSMA = 97.0% (SD 0.180), Mean1-1 = 94.9% (SD 0.238); difference in means 0.020; 95% CI, 0.004–0.036, p = 0.013). SMAs improved satisfaction, learning, and medication compliance, without compromising follow-up rates or measured clinical outcomes. Peer interruptions were negatively correlated with patient satisfaction in early-trial SMAs and positively correlated with patient satisfaction in later-trial SMAs.
Trial registration: The trial was registered with Clinical Trials Registry of India (https://ctri.nic.in/) with reference no. REF/2016/11/012659 and registration no. CTRI/2018/02/011998.
Shifty Eyes: The Impact of Intolerance of Uncertainty on Gaze Behaviour During Threat Conditioning
Authors: Rodriguez-Sobstel Claudia , Wake Shannon , Dodd Helen , McSorley Eugene , van Reekum Carien M. , Morriss Jayne 
Published: July 2023

Previous research has demonstrated that individuals with high levels of Intolerance of Uncertainty (IU) have difficulty updating threat associations to safety associations. Notably, prior research has focused on measuring IU-related differences in threat and safety learning using arousal-based measures such as skin conductance response. Here we assessed whether IU-related differences in threat and safety learning could be captured using eye-tracking metrics linked with gaze behaviours such as dwelling and scanning. Participants (N = 144) completed self-report questionnaires assessing levels of IU and trait anxiety. Eye movements were then recorded during each conditioning phase: acquisition, extinction learning, and extinction retention. Fixation count and fixation duration served as indices of conditioned responding. Patterns of threat and safety learning typically reported for physiology and self-report were observed for the fixation count and fixation duration metrics during acquisition and to some extent in extinction learning, but not for extinction retention. There was little evidence for specific associations between IU and disrupted safety learning (e.g., greater differential responses to the threat vs. safe cues during extinction learning and retention). While there was tentative evidence that IU was associated with shorter fixation durations (e.g., scanning) to threat vs. safe cues during extinction retention, this effect did not remain after controlling for trait anxiety. IU and trait anxiety similarly predicted greater fixation count and shorter fixation durations overall during extinction learning, and greater fixation count overall during extinction retention. IU further predicted shorter fixation durations overall during extinction retention. However, the only IU-based effect that remained significant after controlling for trait anxiety was that of fixation duration overall during threat extinction learning. Our results inform models of anxiety, particularly in relation to how individual differences modulate gaze behaviour during threat conditioning.
Die Ordnung der Natur
Authors: Asmussen-Stratmann Karen , Frank Joachim W. , Matthies Jörg , Hirschfeld Gerhard , Glade Felicitas , Wolschke-Bulmahn Joachim , Unruh Rainer , Imberger Elke 
Published: July 2023

Das Landesarchiv Schleswig-Holstein hat die Landesgartenschau 2009 in Schleswig mit der zu diesem Anlass konzipierten Ausstellung "Die Ordnung der Natur. Historische Gärten und Parks in Schleswig-Holstein" begleitet. Ergänzt wurde diese mit einer Vortragsreihe, die auf große Resonanz stieß. Die Vorträge werden in diesem Band veröffentlicht.
Thematisch gliedert sich der Band in zwei Teile: Die ersten vier Beiträge setzen sich mit historischen Gärten und Parks in Schleswig-Holstein auseinander. Der zweite Teil des Bandes weist über die Grenzen Schleswig-Holsteins hinaus. So geht es um Gartenbauschulen als Berufsausbildung für "höhere Töchter" im Kaiserreich, Gärten und Natur im Kontext demokratiefeindlicher, völkischer Ideologie, die Bedeutung von Gärten und Parks im Film sowie Gärten in Entenhausen.
Effect of the “door-to-balloon” time on the results of treatment of patients with ST-segment elevation myocardial infarction, depending on the duration of the pre-hospital delay
Authors: Bessonov I. S. , Sapozhnikov S. S. , Shadrin A. A. , Kashtanov M. G. , Popov S. V. 
Published: July 2023

Aim To analyze the effect of the door-to-balloon time on treatment outcomes in patients with acute ST-segment elevation myocardial infarction (STEMI) depending on the duration of pre-hospital delay.Material ad methods The study used data of the hospital registry of percutaneous coronary interventions (PCI) in STEMI from 2006 through 2017. The analysis included 1333 patients. All patients were divided into two groups. The first group included 574 (43.1%) patients with the time from the pain syndrome onset to admission was ≤120 min. The second group consisted of 759 (56.9 %) patients with the time of pre-hospital delay exceeding 120 min. Results of the treatment were analyzed for each group depending on the door-to-balloon time, ≤60 min or >60 min.Results In the group of patients with the prehospital delay less than 120 min and the door-to-balloon time ≤60 min vs. patients with the door-to-balloon time >60 min, the following was observed: decreased in-hospital mortality (1.3 % vs. 6.8 %, p=0.001), reduced incidence of major adverse cardiac effects (МАСЕ) (3.2 % vs. 8.3 %, p=0.008), and reduced incidence of the no-reflow phenomenon (3.9 % vs. 9.4 %, p=0.007). Also, immediate angiographic success of PCI was more frequently achieved in these patents (94.5 % vs. 87.5 %, p=0.003). In addition, in the group with the prehospital delay ≤120 min and the door-to-balloon time ≤60 min, a higher ejection fraction was noted at discharge from the hospital (48 [43; 51] % vs. 46 [42; 51] %, р=0.038). Comparison of treatment outcomes between the groups with different door-to-balloon time (≤60 min or >60 min) and a prehospital delay >120 min did not show any significant intergroup differences. According to a multivariate analysis, the door-to-balloon time ≤60 min did not predict in-hospital mortality. There was a strong correlation between the time of prehospital delay and the total time of myocardial ischemia (r=0.87; р<0.001) while the correlation between the door-to-balloon time and the total time of myocardial ischemia was moderate (r=0.41; р<0.001). At the same time, there was no correlation between the time of prehospital delay and the door-to-balloon time.Conclusion In STEMI patients with a prehospital delay less than 120 min from the pain syndrome onset, a decrease in the door-to-balloon time was associated with better outcome of the hospital treatment. When the duration of prehospital delay was more than 120 min, a decrease in door-to-balloon time did not influence the treatment outcome. The time of prehospital delay strongly correlated with the total time of myocardial ischemia.
The CM–CRDS Method for Measuring the Carbon Isotope Ratio in Vanillin With an Expanded Uncertainty of Less Than 0.1 %
Authors: Chubchenko I. K. 
Published: July 2023

Isotopic analysis is an efficient method for quality control and detection of counterfeit food products. The method of elemental analysis isotope ratio mass spectrometry (hereinafter referred to as EA-IRMS) is traditionally used in the field of isotopic analysis of food products and is regulated in the relevant regulatory documents. The method of combustion module-cavity ring-down spectroscopy (hereinafter referred to as CM–CRDS) is a rapidly developing method for measuring the carbon isotope ratio with a number of advantages; currently, this method is of most interest for the isotope analysis of food products. However, studies of the metrological characteristics of the CM–CRDS method as part of the analysis of the isotopic composition of vanillin have not been carried out. The purpose of the research was to develop a procedure for measuring the carbon isotope ratio in vanillin by the CM–CRDS method with an expanded uncertainty (at k = 2) of less than 0.1 ‰.The development of the measurement procedure was carried out in preparation for the international key comparison CCQM-K167 «Carbon isotope delta measurements of vanillin» (2019–2022) organized by the international Working Group on Isotope Ratios of the Consultative Committee for Amount of Substance of the International Bureau of Weights and Measures. The experimental part of the research was carried out on a reference installation, which is part of the State primary standard of units of molar part, mass part and mass concentration of components in gas and gas condensate environs GET 154-2019.The expanded uncertainty (at k = 2) of this procedure for measuring the carbon isotope ratio in vanillin by the CM–CRDS method is less than 0.1 ‰. The following tasks were solved to achieve the set goal: the factors that form the measurement uncertainty budget were identified, some of which were eliminated or minimized by developing a procedure for preparing equipment and samples, a procedure for performing and controlling the measurement accuracy, and a procedure for processing measurement results.The results of international comparisons CCQM-K167 confirmed the possibility of measuring the carbon isotope ratio in vanillin by the CM–CRDS method using the developed procedure with an expanded uncertainty (at k = 2) of 0.09 ‰, which corresponds to the best measurements performed by the EA-IRMS method.The achieved result is of practical importance, because it confirms the possibility of applying the CM–CRDS method for quality control and detection of counterfeit vanillin.Further research will be aimed at developing procedures for measuring the carbon isotope ratio using the CM–CRDS method in other substances and materials analyzed in the food industry, including for quality control and safety confirmation of juice products according to TR CU023/2011 and alcoholic products according to TR EAEU047/2018.
Reference Materials for Nominal Properties of Biological Substances
Authors: Morozova V. V. , Kulyabina E. V. , Morozov V. Yu. , Kulyabina T. V. 
Published: July 2023

Metrological traceability of the research results of the nominal properties of biological substances is currently an unsolved problem. This is primarily due to the absence of CRMs for nominal properties, the lack of requirements and practices in the field of metrology for tools that ensure the traceability of the research results of nominal properties, such as the nucleotide sequence of nucleic acids, DNA, RNA, and the color of urine, and letter codes.In the course of the research, the relevance of the development of the theory, requirements, and practice of using tools in Russian metrology to ensure the traceability of the research results of nominal properties is substantiated. Differences between the process of measurements and studies of nominal properties are given. A project of a metrological traceability chain of the research results of nominal properties to the international harmonization protocol is proposed, taking into account the fact that there are no primary standards of nominal properties, and there are no primary reference methods for measuring nominal properties. Methods for establishing the certified characteristics of reference materials of a fragment of human mitochondrial DNA and the inactivated strain «GK2020/1» of the coronavirus SARS-CoV-2, including additional characteristics of the nominal property «nucleotide sequence of nucleic acids», are presented. Thus, it has been established that the uncertainty of nominal properties can be expressed as a probability or level of confidence. In turn, reference materials of nominal properties are of high interest as a means of metrological assurance of the reliability of identification of the nominal properties of biological substances, which include the DNA nucleotide sequence (genes) of a human being. The main significance of the research is to create prerequisites for the application of the findings given in the work to create a new branch of metrology, which will be related to the creation of methods and means to ensure reliable results for determining the nominal properties of substances and materials.