bluuebunny/crossref_metadata_2025_split huggingface dataset:
<b>Multitarget-Directed Multiple Ligands in Anti-VEGF Resistant Glioblastoma Therapeutics: An in Silico Approach to Identify Potential Phytochemicals</b>
Authors: Arya Kesavan R. , Soumya Sasikumar J. , Nadh Anuroopa G. , Aswathy Thankamani R. , B. Vijayalakshmi , Nair Achuthsankar S. , Oommen Oommen V. , Sudhakaran Perumana R. 
Published: January 2025

Angiogenesis is an important process in tumor progression. Vascular endothelial growth factor (VEGF) is the key factor regulating angiogenesis, and hence, anti-VEGF therapy is considered a useful therapeutic approach in tumor conditions. However, the drug resistance and lack of efficacy of existing drugs limit the potential of such a therapeutic approach in certain cases, and the tumor growth will continue through alternative mechanisms. Glioblastoma (GBM) is one such type of tumor that shows resistance to anti-VEGF therapy. Previously, we identified the hub genes differentially expressed in anti-VEGF resistance in GBM. Medhya Rasayana, an Ayurvedic formulation, is used for the management of neurological disorders. In the present study, we used computational docking methods to identify the phytochemicals present in the medicinal plants of Medhya Rasayana, which can target the proteins expressed by the hub genes associated with anti-VEGF resistance. Network pharmacological analysis was also performed to identify the highly effective phytochemicals for a possible adjuvant therapy. Results showed that multiple phytochemicals of Glycirrhiza glabra Linn, Evolvulus alsinoides, and Celastrus paniculatus target the anti-VGEF resistant proteins in GBM. This indicates the multi-targeting property of phytocompounds of Medhya Rasayana plants, which may be considered for adjuvant therapy along with anti-VEGF therapy.

Received: 10 July 2024 | Revised: 11 October 2024 | Accepted: 6 January 2025

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
The data that support this work are available upon reasonable request to the corresponding author.

Author Contribution Statement
Kesavan R. Arya: Methodology, Formal analysis, Investigation, Writing - original draft, Writing - review & editing, Visualization, Funding acquisition. Sasikumar J. Soumya: Methodology, Formal analysis, Investigation, Writing - original draft, Writing - review & editing,Visualization, Funding acquisition. Anuroopa G. Nadh: Formal analysis, Investigation, Funding acquisition. Thankamani R. Aswathy: Formal analysis, Investigation. Vijayalakshmi B.: Investigation. Achuthsankar S. Nair: Resources, Project administration. Oommen V. Oommen: Validation, Resources, Writing - review & editing, Project administration. Perumana R. Sudhakaran: Conceptualization, Methodology, Validation, Investigation, Resources, Writing - review & editing, Project administration, Funding acquisition.
ANÁLISE DO ACOMPANHAMENTO PRÉ-NATAL DE GESTAÇÕES DE ALTO RISCO EM UM AMBULATÓRIO ESPECIALIZADO DO OESTE DO PARANÁ
Authors: Parzianello Gabrielli , Pezzini Isabella Rodrigues , Rymsza Taciana 
Published: January 2025

Introdução: O acompanhamento pré-natal é essencial para monitorar fatores de risco gestacionais, promover a saúde materna e fetal e reduzir a morbimortalidade materno-infantil. Objetivo: Caracterizar o perfil das gestantes atendidas em um ambulatório especializado, identificando os determinantes de saúde e fatores socioeconômicos associados à gestação de alto risco no Oeste do Paraná. Metodologia: Estudo baseado na aplicação de questionários sociodemográficos e obstétricos em gestantes acompanhadas em um ambulatório de gestação de alto risco. Resultados: A amostra foi composta por 113 gestantes, majoritariamente em idade reprodutiva favorável, com escolaridade de nível médio e renda familiar de até três salários mínimos. Entre os fatores de risco, destacaram-se obesidade (32,47%), hipertensão (22,12%) e tabagismo (11,5%). A maioria era primípara (39,82%) e apresentava intervalo interpartal superior a dois anos (62,83%). Diabetes gestacional foi o principal motivo de encaminhamento ao ambulatório (39,82%). A maior parte das gestantes iniciou o pré-natal precocemente e realizou o número recomendado de consultas (mais de 6). Conclusão: Embora a qualidade do acompanhamento pré-natal tenha se mostrado satisfatória, identificaram-se áreas que requerem aprimoramentos para otimizar o cuidado às gestantes de alto risco.
Predictive scale for in-hospital death in patients with acute heart failure
Authors: Turro Mesa Lucia Nivia , Del Río Caballero Germán , Guzmán Pérez Niger , Mesa German Ricardo del Río , Mesa Valiente Rita María , Carmenaty Margarita Montes de Oca 
Published: January 2025

Introduction: In the context of the prevention of cardiovascular diseases, the high mortality of acute heart failure is a challenge. Objective: Design a scale, based on identified risk factors, for the prediction of early hospital death due to acute heart failure.Methods: An analytical, observational prospective cohort study was carried out that included 127 patients with acute heart failure admitted to the emergency room of the “Saturnino Lora” Provincial Clinical-Surgical Hospital in Santiago de Cuba, from September 2020 to June 2024. They were developed as variable dependent on the patient's condition and as independent of hypothetical clinical, hematological and echocardiographic prognostic factors. The scale was derived from binary logistic regression analysis of the identified cardiovascular risk factors. Results: As the scale score increased, the percentage of deceased patients increased. The area under the curve was 0.881 (p= 0.000) and the Hosmer-Lemeshow goodness-of-fit test obtained p=0.129.Conclusions: The proposed scale made it possible to predict early hospital mortality in patients with acute heart failure, with very good discrimination and calibration capacity.
Pertanian Terpadu Hortukultura Ternak dan Pupuk Organik Di Lahan Kering (Studi Kasus Di PT. Agromar)
Authors: Keytimu Hendrika Yunista , Jeksen Julianus , Bolly Yovita Yasintha 
Published: January 2025

Penelian ini berfokus pada sistem pertanian terpadu hortikultura ternak dan pupuk organik di PT. Agromar indonesia ,kabupaten sikka. PT. Agromar memiliki lahan kering yang sangat cocok untuk diterapkan sistem pertanian terpadu. Penerapan sistem pertanian terpadu yang diterapkan di PT. Agromar adalah solusi pencegahan pencemaran akibat limbah pertanian yang tidak diolah dengan baik. Sistem pertanian terpadu di PT. Agromar memanfaatkan keterkaitan antara tanaman hortikultura, ternak dan pupuk organik. ketiga komponen ini saling berhubungan erat dan saling mendukung antara satu dan yang lain. Metode peneltian yang digunakan adalah observasi, wawancara, dokumentasi, diskusi dan studi literatur. Tujuan dari kegiatan ini adalah mengetahui fungsi dan manfaat dari Sistem Pertanian terpadu dan model Sistem Pertanian Terpadu hortikutura ternak dan pupuk di PT. Agromar.
SWIMMING AS A COMPONENT OF A HEALTH-SAVING ENVIRONMENT IN PHYSICAL EDUCATION CLASSES AT A UNIVERSITY
Authors: Легов Роман Юрьевич 
Published: January 2025

В статье раскрывается актуальность вопроса формирования здоровьесберегающей среды для студентов. Сущность здравоохранительных ценностных ориентаций у студентов. Цель работы - раскрыть особенности плавания как составляющей здоровьесберегающей среды для студентов
The article reveals the relevance of the issue of creating a health-preserving environment for students. The essence of healthcare value orientations among students. The purpose of the work is to reveal the features of swimming as a component of a health-preserving environment for students
FORMULASI SEDIAAN SABUN PADAT TRANSPARAN EKSTRAK ETANOL DAUN TORBANGUN (Plectrantus amboinicus L.)
Authors: Hilmarni  , Safitri Bunga , Rahmayulis  , Rahmi Azimatur 
Published: January 2025

Tanaman Torbangun (Plectrantus amboinicus L) merupakan salah satu tanaman yang ada di Indonesia. Daun torbangun diketahui mengandung senyawa metabolit sekunder diantaranya flavonoid, tanin, fenolik, steroid, saponin, minyak atsiri, dan flavonol, dan tanaman tersebut memiliki aktifitas farmakologi sebagai antibakteri. Penelitian ini dilakukan untuk mengetahui apakah ekstrak etanol daun torbangun dapat diformulasikan menjadi sabun padat transparan. Daun torbangun di ekstraksi menggunakan metode maserasi. Formulasi sediaan sabun padat transparan dibuat sebanyak 4 formula dengan F0 sebagai basis dan penambahan ekstrak etanol daun torbangun pada FI, FII, FIII masing-masing 0.5, 1 dan 2 %. Selanjutnya dilakukan uji evaluasi fisik sediaan sabun padat transparan meliputi pengamatan uji organoleptis, uji kadar air, uji pH, uji iritasi, dan uji tinggi busa. Berdasarkan penelitian yang telah dilakukan maka dapat disimpulkan bahwa ekstrak etanol daun torbangun dapat diformulasikan menjadi sediaan sabun padat transparan dan telah memenuhi persyaratan terhadap uji organoleptis, uji kadar air, uji pH dan uji iritasi.
Pelatihan Pembuatan Teh Kombucha Kepada Anggota PKK Desa Malangsuko, Kecamatan Tumpang
Authors: Nada Raya Muhammad Zakin 
Published: January 2025

AbstractKombucha tea is a fermented beverage. Fermentation in kombucha is assisted by lactic acid bacteria called SCOBY or Symbiotic Culture of Bacteria and Yeast. The use of bacteria as a food processing component has been carried out in various industries. However, practical use in the community is still very minimal due to a lack of education and community empowerment in developing food technology. Training on making kombucha tea in Malangsuko Village is an innovative step to introduce new food technology and superior products, taking advantage of the ease of processing kombucha independently at home. It is hoped that this training can increase the production capacity of kombucha tea and empower communities to develop food technology at the local level.Keywords: kombucha, bacteria, fermentation. AbstrakTeh kombucha merupakan olahan minuman hasil fermentasi. Fermentasi pada kombucha dibantu oleh bakteri asam laktat yang disebut SCOBY atau Symbiotic Culture of Bacteria and Yeast. Pemanfaatan bakteri sebagai komponen pengolahan pangan telah dilakukan pada berbagai industri. Namun pemanfaatan secara praktis dalam lingkungan masyarakat masih sangat minim karenakan oleh kurangnya edukasi dan pemberdayaan masyarakat dalam pengembangan teknologi pangan. Pelatihan pembuatan teh kombucha di Desa Malangsuko menjadi langkah inovatif untuk memperkenalkan teknologi pangan dan produk unggulan baru, memanfaatkan kemudahan pengolahan kombucha secara mandiri di rumah. Pelatihan ini diharapkan dapat meningkatkan kapasitas produksi teh kombucha dan memberdayakan masyarakat dalam mengembangkan teknologi pangan di tingkat lokal.Kata Kunci: kombucha, bakteri, fermentasi.
TINJAUAN HUKUM ISLAM TERHADAP BUDAYA MARSILAMOTAN KETIKA TAKZIAH DI DESA BINANGA PADANG LAWAS
Authors: Tanjung Riska Rahmadani 
Published: January 2025

Takziah merupakan suatu kewajiban bagi seseorang yang beragama muslim terhadap orang yang meninggal. Ketika ada orang yang meninggal dunia, jenazah orang tersebut masih memiliki hak untuk mendapatkan hormat dari orang lain yang masih hidup. Di desa Binanga tepatnya di Padang Lawas ketika ada yang meninggal masyarakat akan mengadakan budaya marsilamotan. Marsilamotan adalah untuk memuliakan tamu dan sebagai sedekah yang pahalanya diberikan kepada si mayyit juga sebagai wujud terimakasih untuk para pentakziah. Menurut hukum islam bahwa budaya marsilamotan boleh, karena ahli musibah menyediakan makanan kepada pentakziah, asal tidak memberatkan dan tujuan bersedekah. Setelah saya teliti masyarakat dipadang lawas mengadakan budaya marsilamotan ini dengan berlebih-lebihan, yang merugikan masyarakat walaupun menyediakannya dengan ikhlas tanpa paksaan. Maka peneliti tertarik membahas judul artikel ini.
Importance Of Ict In The Accounting Of Smes In The Southern Zone Of The State Of Tamaulipas
Authors: Carlos Enrique Martínez del Ángel  , Sofía Genoveva Rivera Espinoza  , Patricia Sotelo Ocampo  
Published: January 2025

ICT have played a very important role in the accounting and administrative system. Through its use, both small and medium sized companies; commercial, industrial, or services, can keep track not only of accounting processes; such as internal control, strategic planning.
Considering that electronic accounting is not mandatory for all companies, someone that are not required, are resistant to this change. However, for them to remain in a competitive market, they must be up to date with new technologies.
According to INEGI data, it is reported that a low percentage of small and medium sized companies have computer, and of these, a great percentage make little use of ICT
The objective of this research is to show the importance of ICT in the accounting and administrative process, Analyze and determine the tools that SMEs can rely on to improve their performance and strengthen their stay on the market. The information obtained from managers is analyzed and the results that describe the relationship between the variables studied are shown, such as control and strategic planning.
Tingkat Kemampuan Teknik Servis Atas dan Bawah pada Mahasiswa UKM Sepak Takraw Universitas Muhammadiyah Surakarta
Authors: Akbar Purnomo  , Nurhidayat Nurhidayat , Vera Septi Sistiasih  
Published: January 2025

Tujuan dari penelitian ini adalah untuk mengetahui seberapa besar tingkat kemampuan servis atas dan bawah pada mahasiswa UKM Sepak Takraw Universitas Muhammadiyah Surakarta. Metode yang digunakan dalam penelitian ini yaitu metode survey dengan teknik pengumpulan data menggunakan tes dan pengukuran. Tempat penelitian ini dilaksanakan di GOR kampus 2 Universitas Muhammadiyah Surakarta kabupaten Sukoharjo Jawa Tengahlapan. Populasi dalam penelitian ini adalah seluruh anggota UKM Sepak Takraw Universitas Muhammadiyah Surakarta siswa dan sampel yang digunakan berjumlah 20 mahasiswa. Syarat dalam pengambilan sampel yaitu mahasiswa yang masih aktif mengikuti UKM Sepak Takraw Universitas Muhammadiyah Surakarta dan tidak sedang mengikuti penelitian lain. Dengan demikian sejumlah 20 mahasiswa yang dipilih sebagai sampel sesuai dengan kriteria yang sudah disebutkan. Instrumen yang digunakan adalah tes ketrampilan servis atas dan tes keterampilan servis bawah. Analisis data dilakukan dengan norma penilaian keterampilan servis atas dan servis bawah dari instrumen tes tersebut. Berdasarkan hasil penelitian yang dilakukan maka didapatkan hasil yaitu Dari 20 mahasiswa yang melakukan tes ketrampilan servis atas, frekuensi yang mendapatkan nilai sangat tinggi 2 mahasiswa (10%), nilai tinggi 5 mahasiswa (25%), nilai sedang 3 mahasiswa (15%), nilai rendah 10 mahasiswa (50%), dan yang mendapatkan nilai sangat rendah 0 mahasiswa (0%). Dari 20 mahasiswa yang melakukan tes ketrampilan servis bawah, frekuensi yang mendapatkan nilai sangat tinggi 2 mahasiswa (10%), nilai tinggi 5 mahasiswa (25%), nilai sedang 3 mahasiswa (15%), nilai redah 10 mahasiswa (25%), dan nilai sangat rendah 0 mahasiswa (0%). Dapat disimpulkan bahwa klasisfikasi tingkat kemampuan servis atas dan bawah pada mahasiswa UKM Sepak Takraw Universitas Muhammadiyah Surakarta dalam kategori rendah.
التوقيع الإلكتروني وحجيته في الإثبات (في النظام السعودي والقانون السوداني دراسة مقارنة)
Authors: المهلاوي كمال عبد الله أحمد المهلاوي 
Published: January 2025

جاء هذا البحث بعنوان (التوقيع الإلكتروني وحجيته في الإثبات -في النظام السعودي والقانون السوداني دراسة مقارنة) متناولاً التوقيع الإلكتروني ‘وحجيته ‘كوسائل مستجدة في الحياة عامة وفي الإثبات بصورة خاصة ومهمة. وكان من الضروري أن نبين أهمية التوقيع الإلكتروني لما تفرضه ضرورة الحياة فكثره الجرائم في هذا العصر أدت إلى ضياع بعض الحقوق لصعوبة إثباتها وظهور المجرم المحترف مع ظهور الجرائم المعلوماتية والتجارة الإلكترونية وكان حرياً أن يضع له المشرع نصوص خاصة لأن المجتمع يحتاج له. ويهدف البحث إلى التعرف على مفهوم التوقيع الإلكتروني وشروطه وحجيته وسلك الباحث المنهج الوصفي الاستدلالي والمنهج المقارن، وخرج بنتائج أهمها، يعبر التوقيع الإلكتروني عن هوية صاحبه وذلك بإصدار شهادة التصديق على التوقيع الإلكتروني، ويمثل صورة من صور التعامل عبر الوسائل التقنية وشبكات الاتصال الحديثة والمعلوماتية وأجهزة الحاسب الألي، إن التوقيع الإلكتروني من الممكن أن يوفر عنصري الثقة والأمان على خلاف ما يعتقده البعض وذلك من خلال تقنيات التشفير وكذلك من خلال دور سلطات التصديق والتوثيق في حماية التوقيع الإلكتروني كاملة في حالات الكشف والعبث به، كما أوصى الباحث، هذه الأدلة الحديثة قد فرضت نفسها في التعامل بقوتها الثبوتية فإني أوصي الجهات المختصة بتطوير هذه الأدلة الحديثة من خلال تفعيل آليات الرقابة على التقديرات الواقعية للقاضي، صياغة نصوص إجرائية خاصة بتنظيم واستخدام التقنيات الحديثة في الكشف عن الجرائم وتعميمها على الجرائم الخطيرة، أوصى المشرع للالتفات بجدية لمسألة التعامل بالمستندات والوثائق الإلكترونية حتى تلحق بركب التطور التكنولوجي السريع في كافة دول العالم
Priority effects, nutrition and milk glycan-metabolic potential drive Bifidobacterium longum subspecies dynamics in the infant gut microbiome
Authors: Pucci Nicholas , Ujčič-Voortman Joanne , Verhoeff Arnoud P. , Mende Daniel R. 
Published: January 2025

Background
The initial colonization of the infant gut is a complex process that defines the foundation for a healthy microbiome development. Bifidobacterium longum is one of the first colonizers of newborns’ gut, playing a crucial role in the healthy development of both the host and its microbiome. However, B. longum exhibits significant genomic diversity, with subspecies (e.g., Bifidobacterium longum subsp. infantis and subsp. longum) displaying distinct ecological and metabolic strategies including differential capabilities to break down human milk glycans (HMGs). To promote healthy infant microbiome development, a good understanding of the factors governing infant microbiome dynamics is required.

Methodology
We analyzed newly sequenced gut microbiome samples of mother-infant pairs from the Amsterdam Infant Microbiome Study (AIMS) and four publicly available datasets to identify important environmental and bifidobacterial features associated with the colonization success and succession outcomes of B. longum subspecies. Metagenome-assembled genomes (MAGs) were generated and assessed to identify characteristics of B. longum subspecies in relation to early-life gut colonization. We further implemented machine learning tools to identify significant features associated with B. longum subspecies abundance.

Results
B. longum subsp. longum was the most abundant and prevalent gut Bifidobacterium at one month, being replaced by B. longum subsp. infantis at six months of age. By utilizing metagenome-assembled genomes (MAGs), we reveal significant differences between and within B. longum subspecies in their potential to break down HMGs. We further combined strain-tracking, meta-pangenomics and machine learning to understand these abundance dynamics and found an interplay of priority effects, milk-feeding type and HMG-utilization potential to govern them across the first six months of life. We find higher abundances of B. longum subsp. longum in the maternal gut microbiome, vertical transmission, breast milk and a broader range of HMG-utilizing genes to promote its abundance at one month of age. Eventually, we find B. longum subsp. longum to be replaced by B. longum subsp. infantis at six months of age due to a combination of nutritional intake, HMG-utilization potential and a diminishment of priority effects.

Discussion
Our results establish a strain-level ecological framework explaining early-life abundance dynamics of B. longum subspecies. We highlight the role of priority effects, nutrition and significant variability in HMG-utilization potential in determining the predictable colonization and succession trajectories of B. longum subspecies, with potential implications for promoting infant health and well-being.
Blood Levels of Organochlorine Contaminants Mixtures and Cardiovascular Disease
Authors: Donat-Vargas Carolina , Schillemans Tessa , Kiviranta Hannu , Rantakokko Panu , de Faire Ulf , Arrebola Juan Pedro , Wolk Alicja , Leander Karin , Åkesson Agneta 
Published: September 2023

ImportanceCardiovascular toxic effects derived from high exposures to individual organochlorine compounds are well documented. However, there is no evidence on low but continuous exposure to combined organochlorine compounds in the general population.ObjectiveTo evaluate the association of combined exposure to several organochlorine compounds, including organochlorine pesticides and polychlorinated biphenyls, with incident cardiovascular disease (CVD) in the general population.Design, Setting, and ParticipantsThis prospective nested case–control study included data from 2 cohorts: the Swedish Mammography Cohort-Clinical (SMC-C) and the Cohort of 60-Year-Olds (60YO), with matched case-control pairs based on age, sex, and sample date. Baseline blood sampling occurred from November 2003 to September 2009 (SMC-C) and from August 1997 to March 1999 (60YO), with follow-up through December 2017 (SMC-C) and December 2014 (60YO). Participants with myocardial infarction or ischemic stroke were matched with controls for composite CVD evaluation. Data were analyzed from September 2020 to May 2023.ExposuresA total of 25 organochlorine compounds were measured in blood at baseline by gas chromatography–triple quadrupole mass spectrometry. For 7 compounds, more than 75% of the samples were lower than the limit of detection and not included.Main Outcomes and MeasuresIncident cases of primary myocardial infarction and ischemic stroke were ascertained via linkage to the National Patient Register (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes I21 and I63). The quantile-based g-computation method was used to estimate the association between the combined exposure to several organochlorine compounds and composite CVD.ResultsOf 1528 included participants, 1024 (67.0%) were female, and the mean (SD) age was 72 (7.0) years in the SMC-C and 61 (0.1) years in the 60YO. The odds ratio of composite CVD was 1.71 (95% CI, 1.11-2.64) per 1-quartile increment of total organochlorine compounds mixture. Organochlorinated pesticides were the largest contributors, and β-hexachlorocyclohexane and transnonachlor had the highest impact. Most of the outcome was not explained by disturbances in the main cardiometabolic risk factors, ie, high body mass index, hypertension, lipid alteration, or diabetes.Conclusions and RelevanceIn this prospective nested case-control study, participants with higher exposures to organochlorines had an increased probability of experiencing a cardiovascular event, the major cause of death worldwide. Measures may be required to reduce these exposures.
Blending
Authors: Renner Vincent 
Published: September 2023

AbstractThis overview of lexical blending includes a definitional discussion, an appraisal of the role of English in its increased frequency in a variety of languages, a taxonomic outline of key types and subtypes, and a focus on two issues of debate – the grammatical or extragrammatical status of blended outputs and the inclusion or exclusion of items made of two initial word fragments. It concludes that two prototypical formal‐cum‐functional strategies of blend formation can be sketched – an associative strategy of novel naming preferably encoded by A{B|C|∅}D constructs and a syntagmatic strategy of compacted renaming preferably encoded by AC constructs.