bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between a single nucleotide polymorphism of the IL23R gene and tuberculosis in a Chinese Han population: a case‒control study
Authors: Zhang Juan , Wang Ming-Gui , Xiang Xi , He Jian-Qing 
Published: July 2023

Abstract
Background
Severe tuberculosis constitutes a significant menace to human safety and well-being, with a considerable mortality rate. The severity of tuberculosis can be impacted by genetic variations in host genes, particularly single nucleotide polymorphisms (SNPs).

Methods
A case‒control study was undertaken, encompassing a cohort of 1137 tuberculosis patients (558 with severe tuberculosis and 579 with mild tuberculosis), alongside 581 healthy controls within the age range of fifteen to forty-five years. Whole blood DNA was extracted from all participants, and three tag polymorphisms (rs1884444, rs7518660, rs7539625) of the IL23R gene were selectively identified and genotyped.

Results
No significant correlation was observed between the IL23R gene polymorphisms (rs1884444, rs7518660, and rs7539625) and tuberculosis. Upon comparing the tuberculosis group with the healthy control group, the mild tuberculosis group with the healthy control group, and the severe tuberculosis group with the healthy control group, the obtained P-values were> 0.05. However, in the comparison between severe tuberculosis and mild tuberculosis, the presence of rs1884444 G alleles exhibited a significantly increased risk of severe tuberculosis after adjusting for age and sex (ORa: 1.199, 95% CI: 1.009–1.424; Pa=0.039, respectively). In subgroup analysis, after accounting for confounding factors, including age and sex, rs1884444 G alleles continued to demonstrate a significantly heightened risk of severe tuberculosis. Nonetheless, the comparison between the multisystemic tuberculosis group and the mild tuberculosis group was no significant difference. Notably, rs1884444 of the IL23R gene exhibited a noteworthy association with the risk of severe tuberculosis in the comparison between severe tuberculosis and mild tuberculosis before and after adjusting for age and sex (ORa: 1.301, 95% CI: 1.030–1.643; Pa=0.027, respectively). Furthermore, the presence of the rs1884444 G allele exhibited a significantly increased risk of severe tuberculosis after adjusting for age and sex in the comparison between tuberculous meningitis and mild tuberculosis (ORa: 1.646, 95% CI: 1.100-2.461; Pa=0.015, respectively).

Conclusions
The present study suggests that there is no significant association between IL23R gene polymorphism and tuberculosis susceptibility in the Chinese Han population. However, it does indicate a potential link between IL23R polymorphism and an increased risk of developing severe tuberculosis.
Spinal epidural abscess as predicting factor for the necessity of early surgical intervention in patients with pyogenic spondylitis
Authors: Park Jiwon , Han Sangsoo , Jeon Yeong , Hong Jae-Young 
Published: July 2023

Abstract
Background
Pyogenic spondylitis is a condition with low incidence that can lead to neurological sequelae and even life-threatening conditions. While conservative methods, including antibiotics and bracing, are considered the first-line treatment option for pyogenic spondylitis, it is important to identify patients who require early surgical intervention to prevent progressive neurologic deficits or deterioration of the systemic condition. Surgical treatment should be considered in patients with progressive neurologic deficits or deteriorating systemic condition. However, currently, there is a lack of treatment guidelines, particularly with respect to whether surgical treatment is necessary for pyogenic spondylitis. This study aims to analyze the radiological epidural abscess on MRI and clinical factors to predict the need for early surgical intervention in patients with pyogenic spondylitis and provide comprehensive insight into the necessity of early surgical intervention in these patients.

Methods
This study retrospectively reviewed 47 patients with pyogenic spondylitis including spondylodiscitis, vertebral osteomyelitis, epidural abscess, and/or psoas abscess. All patients received plain radiographs, and a gadolinium-enhanced magnetic resonance imaging (MRI) scan. All patients have either tissue biopsies and/or blood cultures for the diagnosis of a pathogen. Demographic data, laboratory tests, and clinical predisposing factors including comorbidities and concurrent other infections were analyzed.

Results
We analyzed 47 patients, 25 of whom were female, with a mean age of 70,7 years. MRI revealed that 26 of 47 patients had epidural abscesses. The surgical group had a significantly higher incidence of epidural abscess than the non-surgical group (p = 0.001). In addition, both CRP and initial body temperature (BT) were substantially higher in the surgical group compared to the non-surgical group. There was no significant difference between the surgical group and the non-surgical group in terms of age, gender, comorbidities, and concurrent infectious disorders, as well as the number of affected segments and affected spine levels. However, the surgical group had lengthier hospital stays and received more antibiotics.

Conclusion
The presence of an epidural abscess on MRI should be regarded crucial in the decision-making process for early surgical treatment in patients with pyogenic spondylitis in order to improve clinical outcomes.
Impact of a circular powered stapler on preventing anastomotic leakage in patients with left-sided colorectal cancer: a retrospective study
Authors: Shibutani Masatsune , Fukuoka Tatsunari , Iseki Yasuhito , Kasashima Hiroaki , Kitayama Kishu , Maeda Kiyoshi 
Published: July 2023

Abstract
Background
The powered circular stapler, which was developed with the aim of providing reliable and reproducible anastomosis, provides complete anastomosis, resulting in a reduced risk of anastomotic leakage. The aim of this study was to compare the incidence of anastomotic leakage between a conventional manual circular stapler (MCS) and the ECHELON CIRCULAR™ Powered Stapler (ECPS) in patients with left-sided colorectal cancer who underwent anastomosis with the double stapling technique.

Methods
A total of 187 patients with left-sided colorectal cancer who underwent anastomosis with the double stapling technique with a conventional MCS or the ECPS during surgery at Osaka City University Hospital between January 2016 and July 2022 were enrolled in this study.

Results
The incidence of anastomotic leakage in the ECPS group was significantly lower than that in the MCS group (4.4% versus 14.3%, p = 0.048). Furthermore, even after propensity score matching, an association was found between the use of the ECPS and a reduced incidence of anastomotic leakage.

Conclusion
The ECPS has the potential to help reduce the rate of anastomotic leakage in left-sided colorectal surgery.
The impact of lecture playback speeds on concentration and memory
Authors: Merhavy Zachary I. , Bassett Lukas , Melchiorre Michelle , Hall Maureen P. M. 
Published: July 2023

Abstract
Background
The information required to be learned and retained by medical students has continued to increase over the years. The stress that medical students face has already been highlighted in several studies, however, this in combination with a post-pandemic educational system subsequently generated a shift in medical education towards asynchronous streaming of daily lectures as part of the curriculum with variable playback speed options.

Methods
This paper aims to study the effectiveness of playback speeds, principally that of 1.5x and 2x playback speeds. One objective of this study is to analyze the existing literature regarding how playback speeds may impact learning, and to highlight the need for additional research. It has become apparent that there is not enough literature to support the role that playback speeds have in concentration and/or long-term memory retention in medical students. Due to this lack of information on the topic, this paper additionally highlights a study conducted on second year medical students at one university to assess the associations that may exist between lecture playback speeds of 1.5x and 2x and concentration and long-term retention of memory.

Results
Based on the data collected, it was found that there was no significant difference in student concentration or long-term memory retention with regards to lecture playback speeds.

Conclusions
Although more studies are needed to better understand the topic, it is the current recommendation of the authorial team that students are free to watch medical school lectures at their preferred speed without worry of changes in learning ability.
Lens-related ocular emergencies (LROE) in dogs: treatment and visual outcome after late presentation of 90 eyes
Authors: Ali Khaled M. , Mostafa Ayman A. 
Published: July 2023

Abstract
Background
Lens-related emergencies need immediate medical intervention to reduce complications, minimize pain, and improve the chances of retaining vision. The present study aimed to demonstrate the common lens-related ocular emergencies in dogs and evaluate the short-term outcomes after the treatment of these cases. Sixty dogs (90 eyes) of different breeds were presented with unilateral (30 eyes, OD = 18, OS = 12) and bilateral (60 eyes) ocular abnormalities related to crystalline lens injury. Clinical, ultrasonographic, and laboratory examinations were achieved. Different treatment protocols were conducted after a complete ophthalmic examination and the associated clinical outcomes were evaluated.

Results
Mean (± SD) age of dogs at initial evaluation was 3.65 (± 2.4) years (range, 1˗12 years). Lens luxation and subluxation were diagnosed in 45 eyes (25 with anterior lens luxation, 15 with subluxation, and 5 with posterior lens luxation). Lens-induced anterior uveitis without ocular hypertension (n = 25 eyes), lens-induced uveitis with secondary glaucoma (uveitic glaucoma) (n = 15 eyes), and lens capsule disruption (n = 5 eyes) were also diagnosed. The vision was lost in all 5 eyes with posterior lens luxation and secondary glaucoma (100%), 18/25 eyes with anterior lens luxation (72%), and 5/15 eyes with lens subluxation (33.3%). Vision impairment was also identified in 10/25 eyes (40%) with unresponsive lens-induced anterior uveitis and in 5/5 eyes (100%) with traumatic rupture of the anterior lens capsule.

Conclusion
Crystalline lens pathology can cause a wide variety of ocular emergencies that may result in blindness. Early diagnosis and appropriate treatment are crucial for handling lens-related emergencies in dogs.
An intelligent approach of task offloading for dependent services in Mobile Edge Computing
Authors: Chen Jie , Leng Yajing , Huang Jiwei 
Published: July 2023

AbstractWith the growing popularity of Internet of Things (IoT), Mobile Edge Computing (MEC) has emerged for reducing the heavy workload at the multi-cloud core network by deploying computing and storage resources at the edge of network close to users. In IoT, services are data-intensive and event-driven, resulting in extensive dependencies among services. Traditional task offloading schemes face significant challenges in the IoT scenario with service dependencies. To this end, this paper proposes an intelligent approach for minimizing latency and energy consumption which jointly considers the task scheduling and resource allocation for dependent IoT services in MEC. Specifically, we establish the system model, communication model as well as computing model for performance evaluation by fully considering the dependent relationships among services, and an optimization problem is proposed for minimizing the delay and energy consumption simultaneously. Then, we design a layered scheme to deal with the service dependencies, and present detailed algorithms to intelligently obtain optimal task scheduling and resource allocation policies. Finally, simulation experiments are carried out to validate the effectiveness of the proposed scheme.
The Impact of Sleep Interventions on Athletic Performance: A Systematic Review
Authors: Cunha Lúcio A. , Costa Júlio A. , Marques Elisa A. , Brito João , Lastella Michele , Figueiredo Pedro 
Published: July 2023

AbstractBackgroundSleep is essential for maximal performance in the athletic population. Despite that, the sport context has many factors that can negatively influence athletes’ sleep and subsequent recovery.ObjectivesThe purpose of this systematic review was to synthesize the most recent literature regarding sleep interventions aimed at improving sleep and subsequent performance in athletes.MethodsThe present systematic review was conducted based on the PRISMA guidelines and the PICOS approach. The search was conducted in May 2022 using the electronic database PubMed, SPORTDiscus via EBSCOhost, and Web of Science. Once extracted, studies were included if they met the following criteria: (1) participants were athletes of individual or team sports; (2) implemented an intervention aimed at improving sleep; (3) measured at least one objective performance/recovery outcome; and (4) reported the relationship between sleep and performance.ResultsThe search returned 1584 records. Following the screening, a total of 25 studies met our inclusion criteria. All the included articles were intervention studies published between 2011 and 2021. The included studies implemented various sleep interventions, such as sleep hygiene, naps, sleep extension, light manipulation, cold water immersion, mindfulness, or a combination of two or more strategies. Sleep extension and naps were the most representative and most effective strategies to improve sleep and performance. Mindfulness and light manipulation demonstrated promising results, but more studies are needed to confirm these findings. Sleep hygiene, removing electronic devices at night, and cold water immersion had no effects on sleep and subsequent performance/recovery, but these results are based on a few studies only.ConclusionWhile acknowledging the limited amount of high-quality evidence reviewed, it appears that increasing sleep duration at night or through napping was the most effective interventions to improve physical and/or cognitive performance.Protocol RegistrationThis protocol was registered in the International Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY) on May 11, 2022, with the registration number INPLASY202250069.
TAFSIRAN HOMOSEKSUAL DI ANTARA PENGKAJI BIBLE DENGAN TEKS KISAH SODOM: SATU ANALISIS PERBANDINGAN
Authors: Md Yasim Mohd Azwan , Muhammad Azizan bin Sabjan  
Published: July 2023

The story of Sodom is an event of torment due to homosexual behavior. However, the text of the story of Sodom was reinterpreted by Bible scholars as appropriate. Accordingly, this study brings together the issues in the Story of Sodom. These issues are raised by Bible scholars in the fight for the fate of homosexuals. Based on the literature review, it was found that Bible scholars did not condemn homosexuality for the following reasons: the authenticity of the same-sex text in the story of Sodom is disputed; the purpose of the inhabitants of Sodom conducting a survey; causes of same-sex attempts; Lot's stance on same-sex union; the cause of the destruction of the people of Sodom; the purpose of the inhabitants of Sodom was to seduce Lot's guests; and the appropriateness of the story of Sodom as a lesson. Accordingly, in order to obtain accurate evidence, content analysis was conducted by comparing the Bible scholars' interpretation with the text of the story of Sodom in the Bible. Successful analysis proves that the prohibition of same-sex union described in the story of Sodom is clear. It can be used as a strong argument to forbid Christians who practice homosexuality.

Kisah Sodom merupakan satu kejadian azab akibat kelakuan homosekual. Namun, teks kisah Sodom ditafsir semula oleh pengkaji Bible mengikut kesesuaian semasa. Sehubungan itu, kajian ini menghimpunkan isu-isu di dalam Kisah Sodom. Isu-isu ini dibangkitkan oleh pengkaji Bible dalam memperjuangkan nasib homoseksual. Berdasarkan kepada kajian kepustakaan, didapati bahawa pengkaji Bible tidak mengutuk homoseksual di atas sebab: kesahihan teks seks sesama jantina di dalam kisah Sodom dipertikaikan; tujuan penduduk Sodom melakukan tinjauan; punca kepada cubaan seks sesama jantina; pendirian Lot terhadap seks sesama jantina; punca kemusnahan penduduk Sodom; tujuan penduduk Sodom ingin meliwat tetamu Lot; dan kesesuaian kisah Sodom sebagai pelajaran. Sehubungan itu, bagi mendapat bukti yang tepat, analisis kandungan telah dijalankan dengan membandingkan di antara tafsiran pengkaji Bible dengan teks kisah Sodom di dalam Bible. Analisis berjaya membuktikan bahawa larangan seks sesama jantina yang dijelaskan di dalam kisah Sodom adalah jelas. Ia mampu dijadikan hujah yang kuat untuk melarang penganut Kristian yang mengamalkan homoseksual.
New Hybrid MCDM Approach for an Optimal Selection of Maintenance Strategies: Results of a Case Study
Authors: Khanfri N. E. H. , Ouazraoui N. , Simohammed A. , Sellami I. 
Published: July 2023

Summary
Industrial systems are becoming more sophisticated, and their failure can result in significant losses for the company in terms of production loss, maintenance costs, fines, image loss, etc. Conventional approaches to modeling and evaluating the failure mechanisms of these systems do not consider certain important aspects, such as the interdependencies between failure modes (FMs) with information and data containing uncertainties as they are generally collected from experts’ judgments. These restrictions may lead to improper decision-making. The use of more advanced techniques to model and assess the interdependencies among components’ failures under uncertainties seems to be more than necessary to overcome these deficiencies.
It is in this context that the proposed approach fits. It consists of proposing a hybrid multicriteria decision-aking (MCDM) approach that combines several techniques for a better selection of maintenance strategies. Using the failure mode and effects analysis (FMEA) technique, the potential FMs of components, along with their causes and effects, are identified. The relative importance (or weight) of these FMs is determined using the fuzzy simple additive weighing (FSAW) method based on how they affect the system’s goals. The causal relationships between FMs and their final weights are determined by the fuzzy cognitive maps (FCM) method and the nonlinear Hebbian learning and differential evolution (NHL-DE) algorithm. Finally, based on the final FM weights provided by the FCM, the simple additive weighing (SAW) method is used to select the optimal maintenance strategies. The results of applying the proposed approach to an operating compressor lubrication and sealing oil system demonstrate its importance and usefulness in assisting system operators to efficiently allocate the optimal maintenance strategies, considering the strong correlation between FMs and their effects on system performance while accounting for the uncertainties associated with experts’ judgments. These correlation effects have led to changes in the assigned weights of the selected FMs. Specifically, the FM related to the low output of the lube/seal oil pump, which was initially assigned a lower priority, and with the correlation effects has become the first critical FM. This shift in prioritization emphasizes the need to address this particular FM promptly. By focusing on addressing these high-priority FMs, maintenance efforts can be optimized to prevent or mitigate more severe consequences. Among the various maintenance strategies evaluated, it was determined that the combination of condition-based maintenance (CBM) and precision maintenance (PrM) yields the most favorable outcome in terms of mitigating the impact of accidental failures and undesired events on the selected system.
Comparing Traditional Methods for Rock Masses Volume Estimation and Those Assisted by UAV’s
Authors: Gava Joao Pedro Corona , Souza Felipe Ribeiro , Destro Elton 
Published: July 2023

Abstract
Unmanned Aerial Vehicles (UAVs), Remotely Piloted Aircraft (RPA) or simply Drones, were first utilized for military purposes prior to World War I. With the popularity of its technology, UAVs are now being utilized for photography, cinema, sports, precision agriculture, and mining. UAVs in mining allow professionals to collect data from wide territories that are typically difficult to access, with outstanding cost/benefit ratio, operational time and reduced manpower. The aircraft’s capabilities include reconnaissance of the area, generation of Digital Terrain and Elevation Models (MDTs and MDEs), and monitoring of mining operations. Despite all of the advantages provided by UAVs, there is tremendous space for technological advancement. It is still a new tool that is heavily reliant on ideal climatic conditions, and without an RTK (Real Time Kinematic) station, the error in the coordinates can approach the magnitude of dozens of meters. For these reasons, more conservative miners and government agencies continue to be skeptical of UAV use. This study showed that, when combined with appropriate processing, data gathered with UAVs can produce results comparable to traditional approaches in less time and at comparable prices.
The biogenesis of large extracellular vesicles occurs in mitosis
Authors: Patel Smit , Park Sungjin , Torr Elizabeth , Zhu Dantong , Dureke Ashley-Grace , McIntyre Alina , Severson Jackson , Muzyka Nadiya , Skop Ahna 
Published: July 2023

Abstract
Cells communicate with neighboring cells through shedding and uptake of extracellular vesicles (EVs). EVs are small packages of nucleic acid and protein enclosed in a lipid bilayer. Despite being broadly studied since 2010, the biogenesis of EVs remains elusive. Currently, cells in interphase are thought to shed the bulk of EVs. Given that cancer cells shed more EVs than non-cancerous cells, we hypothesized that the primary origin of large EVs may be mitosis. Here, we demonstrate that the biogenesis of large EVs occurs in mitosis. We found that the canonical EV markers, CD9, CD63, CD81, flotillin-1, and dsRNA, localize to the spindle midzone microtubules, midbody, and midbody remnant (MBR) during mitosis. These EV markers co-localized with the master regulator of cytokinesis, MKLP1, throughout mitosis, suggesting that large EV assembly and packaging occur during mitosis. Next, we showed that standard, commercial, and our newly developed EV isolation methods all isolate MBRs, evidenced by the presence of CD9 and MKLP1 double-positive vesicles. We developed two new methods of large EV isolation utilizing 1.5% PEG 6000 and PEGylated gold nanoparticles. Regardless of the isolation method, EVs are characterized using markers for transmembrane proteins called tetraspanins (CD9, CD63, and CD81), and found that ~99% of all isolated MKLP1-labeled vesicles were also CD9 positive, suggesting that large EVs are MBRs, not a separate class of EVs. Additionally, all isolation methods tested suggest that large EV have translation capacity, distinct from other EV classes. Our results demonstrate that mitotic cells give rise to the bulk of large EVs commonly researched in the field. Importantly, we show that all commercial isolation methods for EVs actually isolate MBRs, suggesting that experiments performed in the EV field are of mitotic origin. This work has broad implications for the assembly and packaging of large EVs, specifically for engineering drug therapeutics and isolation of large EVs, or MBRs, for cancer diagnosis.