bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resilience of maize, wheat, and soybean cropping systems as affected by fertilization: Analysis of a long‐term field network
Authors: Manenti Luis , Macholdt Janna , Garcia Fernando O. , Rubio Gerardo 
Published: March 2023

AbstractElucidating how different fertilization treatments affect the resilience of farming systems and the environmental adaptability of agricultural crops is relevant to assess their efficacy as a strategy for minimizing yield fluctuations and supporting global food security. The aim of this work was to compare the effects of fertilization practices and to distinguish the effect of macronutrients on the resilience of maize, wheat, and soybean cropping systems. A long‐term experiment involving the three crops and five fertilization treatments (control without fertilization, nitrogen and sulphur fertilization, phosphorus and sulfur fertilization, nitrogen and phosphorus fertilization, nitrogen, phosphorus and sulfur fertilization) was conducted for 19 years in the Pampean region (Argentina) that includes five study sites. The four combinations of nutrient additions increased crop yields in unfavorable environments, which indicates that even in adverse years, fertilization was a valid tool to sustain yield performance. The Finlay and Wilkinson regression slopes in maize and full‐season soybean did not differ between fertilization treatments, which suggests that fertilization did not change crop adaptation to the environment and that the observed positive effect of fertilization in unfavorable environments was maintained along the environmental gradient. In contrast, wheat and double‐cropped soybean were able to capitalize on the environmental conditions of favorable years, as shown by the progressive increases in yields as the environment became more favorable. Maize had the highest response to nitrogen, whereas wheat and double‐cropped soybean exhibited the highest responses to phosphorus and sulfur, respectively. Our findings are useful to extract guidelines that may lead to greater resilience through fertilization management practices.
The impact of receiving polygenic risk scores for alcohol use disorder on psychological distress, risk perception, and intentions to reduce drinking
Authors: Driver Morgan N. , Kuo Sally I‐Chun , Dron Jacqueline S. , Austin Jehannine , Dick Danielle M. 
Published: March 2023

AbstractFor the return of polygenic risk scores to become an acceptable clinical practice in psychiatry, receipt of polygenic risk scores must be associated with minimal harm and changes in behavior that decrease one's risk for developing a psychiatric outcome. Data from a randomized controlled trial was used to assess the impact of different levels of hypothetical polygenic risk scores for alcohol use disorder on psychological distress, risk perception, and intentions to change drinking behaviors. The analytic sample consisted of 325 participants recruited from an urban, public university. Results demonstrated that there were significant increases in psychological distress as the level of genetic risk for alcohol use disorder increased. In addition, the perceived chance of developing alcohol use disorder significantly increased as the level of genetic risk increased. Promisingly, a greater proportion of participants indicated that they would intend to engage in follow‐up behaviors, such as seeking additional information, talking to a healthcare provider about risk, and reducing drinking behaviors, as the level of genetic risk increased. Returning polygenic risk scores for alcohol use disorder in a clinical setting has the potential to promote risk‐reducing behavior change, especially with increasing levels of genetic risk. The study was registered on ClinicalTrials.gov (Identifier: NCT05143073).
Ein Kooperatives Rhodium/Sekundäres Phosphinoxid [Rh/P(O)nBu2]‐Template zur Katalytischen Hydrodefluorierung von Perfluoroarenen
Authors: Chang Wei‐Chieh , Randel Helena , Weyhermüller Thomas , Auer Alexander A. , Farès Christophe , Werlé Christophe 
Published: March 2023

AbstractDie selektive Aktivierung von C‐F‐Bindungen unter milden Reaktionsbedingungen ist nach wie vor eine Herausforderung im Bereich der Bindungsaktivierung. Hier stellen wir ein kooperatives [Rh/P(O)nBu2]‐Template für die katalytische Hydrodefluorierung (HDF) von Perfluorarenen vor. Zusätzlich zu Substraten mit elektronenziehenden funktionellen Gruppen zeigte das System eine äußerst seltene Toleranz gegenüber elektronenschiebenden funktionellen Gruppen und Heterozyklen. Die hohe Chemoselektivität des Katalysators und die Möglichkeit, ihn im präparativen Maßstab einzusetzen, verdeutlichen seine Praxistauglichkeit. Empirische mechanistische Studien und eine Dichtefunktionaltheorie (DFT)‐Studie haben einen Rhodium(I)‐Dihydrid‐Komplex als katalytisch relevante Spezies identifiziert und die entscheidende Rolle von Phosphinoxid als kooperatives Fragment ermittelt. Insgesamt zeigen wir, dass molekulare Templates, welche auf diesen Designelementen basieren, zusammengesetzt werden können, um Katalysatoren mit erhöhter Reaktivität für anspruchsvolle Bindungsaktivierungen zu schaffen.
Ein m‐Terphenylisocyanid stabilisiert 17‐Elektronen‐Monoradikale von drei Elementen der Gruppe 7
Authors: Salsi Federico , Wang Shuai , Teutloff Christian , Busse Marvin , Neville Michael L. , Hagenbach Adelheid , Bittl Robert , Figueroa Joshua S. , Abram Ulrich 
Published: March 2023

AbstractEine erste konsistente Serie einkerniger 17‐Elektronenkomplexe von drei Elementen der Gruppe 7 wurde in kristalliner Form hergestellt und durch Röntgenkristallstrukturanalyse sowie spektroskopische Methoden untersucht. Die paramagnetischen Verbindungen der Zusammensetzung [M0(CO)(CNp‐F‐ArDArF2)4] (M=Mn, Tc, Re; ArDArF2=2,6‐(3,5‐(CF3)2C6H3)2C6H2F)) werden durch jeweils vier sterisch anspruchsvolle Isocyanid‐Liganden stabilisiert, wodurch auch eine Dimerisierung der Metalloradikale verhindert wird. Die Verbindungen besitzen eine quadratisch‐pyramidale Struktur mit jeweils einem Carbonyl‐Liganden als Apex. EPR‐Spektren der Technetium‐ und Rheniumverbindungen zeigen eine deutliche Anisotropie mit großen 99Tc und 185,187Re‐Hyperfeinstrukturkopplungen für jeweils eine der Komponenten. Für die Bestimmung der EPR‐Parameter des entsprechenden Mn0‐Komplexes wurde Hochfeld‐EPR (Q‐Band und W‐Band) verwendet.
A Complete Triad of Zero‐Valent 17‐Electron Monoradicals of Group 7 Elements Stabilized by m‐Terphenyl Isocyanides
Authors: Salsi Federico , Wang Shuai , Teutloff Christian , Busse Marvin , Neville Michael L. , Hagenbach Adelheid , Bittl Robert , Figueroa Joshua S. , Abram Ulrich 
Published: March 2023

AbstractThe first consistent series of mononuclear 17‐electron complexes of three Group 7 elements has been isolated in crystalline form and studied by X‐ray diffraction and spectroscopic methods. The paramagnetic compounds have a composition of [M0(CO)(CNp‐F‐ArDArF2)4] (M=Mn, Tc, Re; ArDArF2=2,6‐(3,5‐(CF3)2C6H3)2C6H2F) and are stabilized by four sterically encumbering isocyanides, which prevent the metalloradicals from dimerization. They have a square pyramidal structure with the carbonyl ligands as apexes. The frozen‐solution EPR spectra of the rhenium and technetium compounds are clearly anisotropic with large 99Tc and 185,187Re hyperfine interactions for one component. High‐field EPR (Q band and W band) has been applied for the elucidation of the EPR parameters of the manganese(0) complex.
Development of polyamide/polyacrylonitrile thin film composite RO membranes by interfacial polymerization assisted with an aromatic/aliphatic organic solvent mixture
Authors: Mokarinezhad Nikan , Hosseini Seyed Saeid , Nxumalo Edward Ndumiso 
Published: March 2023

AbstractThe proper control of polymerization is a prerequisite in fabrication of thin film composite reverse osmosis (RO) membranes. But it not trivial when hydrophilic substrates are used. Herein, we report an innovative approach which involves using an aromatic/aliphatic solvent mixture of toluene and n‐hexane as the organic phase for interfacial polymerization. Membranes were tuned by using a customized developed polyacrylonitrile (PAN) substrate and exploring the impacts of organic solvent and curing temperatures on their morphology and performance characteristics. Results revealed that increasing the temperature of organic phase to 20°C improved salt rejection significantly to 98.6% with the flux of 16.1 LMH. However, its further increase to 30°C was not beneficial due to formation of a looser chain packing which led to rejection drop. In addition, raising curing temperature to 90°C was not favorable due to transformation of surface morphology from ridge‐and‐valley to nodular structure, accompanied with defective sites at the selective layer and insufficient degree of crosslinking evidenced by declines in both flux and rejection to 11.1 LMH and 83.4%, respectively. Overall, the findings suggested that an optimal performance could be obtained by using a solvent mixture of toluene/n‐hexane (1,1) and setting organic solvent and curing temperatures to 20 and 70°C, respectively.
Quantifying the hybrid flow and aperture forming of liquid metals immersed in NaOH solution under rotating magnetic field
Authors: Li Nan , Wang Lei , Liu Jing 
Published: March 2023

AbstractLiquid metal (LM) immersed in solutions exhibited profound fluidic phenomena under various working situations. With persistent research endeavor, a growing number of intriguing phenomena along this direction have been increasingly disclosed. Among the many critical issues, quantifying the hybrid flow of LMs and surrounding solutions often encounters tough challenges due to the large property differences between the two fluids, including density, electrical and fluidic characteristics, and so forth. Especially, when the electromagnetic field is involved, the problems would become ever complicated. In this article, to characterize the hybrid fluids of LM and NaOH solution under rotating magnetic field (RMF), we established a coupled three‐dimensional model considering magnetic effect on the two‐phase flow. The computational prediction of the model was validated through comparing the simulated morphological features of LM with the experimental measurements at different rotational speeds of magnetic field. Finally, two phenomena were revealed with potential applications interpreted: (1) LM would accelerate the solution due to their difference in viscosity; (2) an asymmetric flow and tunable hole formation under RMF will occur due to the surface tension redistribution on LM. The present works are expected to provide reliable guidance for quantifying the multiphase flow behaviors of hybrid fluids composed of LM and other liquids. The revealed hole size dominated LM aperture is especially useful for developing future smart optical switch and electromagnetic shielding devices.
pH‐ and Temperature‐responsive Hydrogels Based on Tertiary Amine‐modified Polypeptides for Stimuli‐responsive Drug Delivery
Authors: Lin Zhiqiang , Ding Junfeng , Chen Xuesi , He Chaoliang 
Published: March 2023

AbstractpH‐ and temperature‐responsive hydrogels have attracted considerable attention due to their responsiveness to dual physiologically‐relevant stimuli. In this study, we developed stimuli‐responsive hydrogels based on monomethoxy poly(ethylene glycol) (mPEG)‐polypeptide block copolymers containing various tertiary amine pendants (EEP‐TAs). The EEP‐TAs were synthesized via ring‐opening copolymerization of α‐amino acid N‐carboxyanhydrides, and further modified post‐polymerization with click chemistry. The EEP‐TAs exhibited an α‐helix‐to‐β‐sheet transition when the pH was increased from 4.0 to 7.4. At elevated polymer concentrations, aqueous solutions of the EEP‐TAs underwent thermo‐induced sol–gel phase transitions, which were dependent on the pH. The hydrogels almost fully degraded within 3 weeks in the subcutaneous layer of mice and exhibited good histocompatibility in vivo. Additionally, doxorubicin (DOX)‐loaded hydrogels exhibited pH‐responsive drug release profiles in vitro, which were composed of rapid release at acidic pH and more sustained release at neutral pH. Thus, these polypeptide hydrogels hold potential as depots for environment‐responsive delivery of therapeutic agents.
The hyperluminous X‐ray source population
Authors: MacKenzie A. D. A. , Roberts T. P. , Walton D. J. 
Published: March 2023

AbstractWe have recently published a catalog of 1843 candidate ultraluminous X‐ray sources (ULXs). This is the largest catalog of ULXs to date and was built by cross‐correlating recent serendipitous source catalogs from the XMM‐Newton, Swift, and Chandra observatories with a large sample of galaxies, primarily from HyperLEDA. The catalog contains 71 hyperluminous X‐ray source (HLX) candidates, the most extreme members of the ULX population with luminosities above 1041 erg s−1. These sources are often considered the best candidates for intermediate‐mass black hole (IMBH) accretors and include the archetypal IMBH candidate ESO 243–49 HLX‐1. However, the most luminous of the known pulsating ULXs, NGC 5907 ULX1, is also an HLX at its brightest. We demonstrate that these two objects occupy distinct areas of the hardness‐intensity parameter space, and use this to contextualize the results from a pilot study of three data‐rich examples of the 42 HLXs we select as the best candidates based on their multi‐wavelength counterparts and X‐ray data quality. We briefly discuss the implications of this work.
Tunnel‐Type Na2Ti6O13@Carbon Nanowires as Anode Materials for Low‐Temperature Sodium‐Ion Batteries
Authors: Lai Qing‐Song , Mu Jian‐Jia , Liu Zhao‐Meng , Zhao Lu‐Kang , Gao Xuan‐Wen , Yang Dong‐Run , Chen Hong , Luo Wen‐Bin 
Published: March 2023

AbstractEconomical efficient anode materials play an important role in low‐temperature sodium‐ion batteries (SIBs). Tunnel‐type structured Na2Ti6O13@C nanowires were synthesized and utilized as anode material for low‐temperature SIBs. The appropriate interlayer spacing for sodium ion insertion and short diffusion pathway can accelerate the sodium ion kinetics and decrease the apparent activation energy at low temperature. The diffusion apparent activation energy and activation energy for Na2Ti6O13@C were calculated to be 42.0 kJ mol−1 and 15.3 kJ mol−1 with the sodium ion diffusion coefficients about 10−12 cm2 s−1. The Na2Ti6O13@C nanowires exhibit a high reversible capacity of 100 mAh g−1 at 0 °C with 99.6 % retention after 200 cycles at 0.5 C. Coupling with the sodium vanadium phosphate as cathode, the assembled Na2Ti6O13@C||NVP full‐cell can keep a 65 % capacity retention after 175 cycles at 0 °C. This work presents that Na2Ti6O13@C nanowires can be an ideal type of anode active materials for low‐temperature SIBs.
Advances in medical treatment of advanced hepatobiliary and pancreatic cancer in 2022
Authors: Zhang Le , Liu Rui , Deng Ting , Ba Yi 
Published: March 2023

AbstractThis article summarizes the drug therapy progress of advanced hepatocellular carcinoma, biliary tract cancer, and pancreatic cancer in 2022, including chemotherapy, molecular targeted therapy, and immunotherapy, to provide reference information for current clinical treatment and future clinical research, and to better improve prognosis and quality of life in patients with hepatobiliary and pancreatic cancer.
Identification of a copper metabolism‐related gene signature for predicting prognosis and immune response in glioma
Authors: Li Ling , Leng Wenyuan , Chen Junying , Li Shaoying , Lei Bingxi , Zhang Huasong , Zhao Huiying 
Published: March 2023

AbstractBackgroundGliomas are highly refractory intracranial cancers characterized by genetic and transcriptional heterogeneity. However, therapeutic options are limited. In the last years, copper‐induced cell death is becoming a prospective treatment strategy for gliomas and other solid tumors, but copper metabolism‐related genes associated with cancer development remain unclear.MethodsWe first collected gene expression data from The Cancer Genome Atlas (TCGA) to identify significantly differentially expressed copper metabolism‐related genes in gliomas. Using these genes, we performed COX regression and Least Absolute Shrinkage and Selection Operator (LASSO) regression to construct the prognostic model. The prognostic value of the model was further validated by CGGA testing set. Subsequently, functional analyses were carried out, including gene set enrichment analysis (GSEA), immune infiltration analysis, and mutation analysis. Finally, the expression levels of these genes were verified by immunohistochemical analysis.ResultsThe prognostic model consisted of 7 genes: CDK1, LOXL2, LOXL3, NFE2L2, SLC31A1, SUMF1 and FDX1. According to this prognosis model, glioma patients could be split into the high‐risk group or low‐risk group, and the low‐risk group showed significantly better prognostic survival (p < 0.001). Moreover, the high‐risk group had higher levels of immune cell infiltration, immune checkpoint genes expression, and higher tumor mutational burden (TMB), which indicates that they might benefit more from immunotherapy. Finally, we confirmed the expression level of FDX1, SUMF1, and SLC31A1 protein as significantly different in glioblastoma, lower‐grade glioma, and non‐tumor brain tissues by immunohistochemical analysis, and the high expression of FDX1 and SLC31A1 protein was related to poor survival in glioma patients.ConclusionsOur study could contribute to the prognosis prediction and decision‐making in patients with gliomas.
Facile Electrochemical Preparation of Hydrophobic Antibacterial Fabrics Using Reduced Graphene Oxide/Silver Nanoparticles
Authors: Jafari Behnaz , Lacerda Carla M. R. , Botte Gerardine G. 
Published: March 2023

AbstractInvited for this issue's Front Cover are Behnaz Jafari and Prof. Botte from the research group Chemical and Electrochemical Innovation and Technology Laboratory, Texas Tech University in collaboration with Dr. Lacerda from University of Texas at Tyler. The Front Cover shows schematically the in‐situ electrochemical reduction of graphene oxide and electrodeposition of silver nanoparticles on the fabric. The reduced graphene oxide/silver‐coated fabrics demonstrated electroconductivity, hydrophobicity, and antibacterial activity with a controlled release of silver ions which makes their antibacterial effect durable. Read the full text of the Research Article at 10.1002/celc.202201111.
Photoluminescent Properties and Mechanism of Novel Cyanine‐Borondifluoride Curcuminoid Hybrids as Red‐to‐Near Infrared and Endoplasmic Reticulum‐Targeting Dyes
Authors: Gong Shan‐Shan , Chen Li‐Li , Du Ke , Yin Yuwen , Yang Rui‐Xue , Shi Rongwei , Peterson Blake R. , Feng Fude , Sun Qi 
Published: March 2023

AbstractSynthesis‐oriented design led us to the discovery of a series of novel cyanine‐borondifluoride curcuminoid hybrids called Nanchang Red (NCR) dyes that overcome the intrinsic low synthetic yields of symmetrical cyanine‐difluoroboronate (BF2)‐hybridized NIR dyes. The hybridization endows NCR dyes with high molar extinction coefficients, efficient red‐to‐NIR emission, and enlarged Stokes shifts. Quantum chemical calculations revealed that the asymmetrical layout of the three key electron‐withdrawing and electron‐donating fragments results in a special pattern of partial charge separation and inconsistent degrees of charge delocalization on their π‐conjugated backbones. While the nature of the hemicyanine fragment exerts significant influence on the excitation modes of NCR dyes, the borondifluoride hemicurcuminoid fragment is the major contributor to the enlarged Stokes shifts. Cell imaging experiments illustrated that a subtle change in the N‐heterocycle of the hemicyanine fragment has a remarkable effect on the subcellular localization of NCR dyes. Unlike other previously reported cyanine‐BF2 hybridized dyes, which mainly target mitochondria, the benzothiazole and indole‐based NCR dyes accumulate in both the endoplasmic reticulum (ER) and lipid droplets of HeLa cells, whereas the benzoxazole and quinoline‐based NCR dyes stain the ER specifically.
Zebrafish null mutants of Sept6 and Sept15 are viable but more susceptible to Shigella infection
Authors: Torraca Vincenzo , Bielecka Magdalena K. , Gomes Margarida C. , Brokatzky Dominik , Busch‐Nentwich Elisabeth M. , Mostowy Serge 
Published: March 2023

AbstractSeptins are evolutionarily conserved GTP‐binding proteins known for their roles in cell division and host defence against Shigella infection. Although septin group members are viewed to function as hetero‐oligomeric complexes, the role of individual septins within these complexes or in isolation is poorly understood. Decades of work using mouse models has shown that some septins (including SEPT7) are essential for animal development, while others (including SEPT6) are dispensable, suggesting that some septins may compensate for the absence of others. The zebrafish genome encodes 19 septin genes, representing the full complement of septin groups described in mice and humans. In this report, we characterise null mutants for zebrafish Sept6 (a member of the SEPT6 group) and Sept15 (a member of the SEPT7 group) and test their role in zebrafish development and host defence against Shigella infection. We show that null mutants for Sept6 and Sept15 are both viable, and that expression of other zebrafish septins are not significantly affected by their mutation. Consistent with previous reports using knockdown of Sept2, Sept7b, and Sept15, we show that Sept6 and Sept15 are required for host defence against Shigella infection. These results highlight Shigella infection of zebrafish as a powerful system to study the role of individual septins in vivo.
Chiral Amine Catalyzed Reductive Aldol/Reductive Michael Addition Cascade Towards Enantioselective Synthesis of Benzannulated Diquinanes
Authors: Midya Abhisek , Devidas Khalse Laxman , Ghorai Prasanta 
Published: March 2023

AbstractDisclosed here an amine‐catalyzed reductive aldol‐condensation followed by an intramolecular reductive Michael‐addition cascade employing Hantzsch ester as hydride source to a keto‐bis‐enone to provide enantio‐ and diastereoselective benzannulated diquinanes having three consecutive stereocenters, one of which is an all‐carbon quaternary formyl stereocenter. Interestingly, on changing a tether connecting the ketone and an enone moiety from an aliphatic to an aromatic, a change in reactivity is observed. In this case, instead of the above‐mentioned reductive aldol condensation, an asymmetric aldol reaction occurs, followed by an iminium/enamine isomerization and, finally diastereoselective Michael addition reaction occurs. As a result, a bis‐benzannulated diquinane is obtained with vicinal congested quaternary chiral centers.
C2‐Cyanomethyl (CNMe) Ether‐Protected Glycosyl Trichloroacetimidate Donors for Stereoselective β‐O‐Glycosylations
Authors: Rahaman Molla Mosidur , Thakur Rima , Aghi Anjali , Kumar Amit 
Published: March 2023

AbstractStereoselective construction of glycosidic linkages have emerged as one of the pivotal aspects for the synthesis of complex oligosaccharide assemblies. We herein report C2‐cyanomethyl (CNMe) ether as a strong stereodirecting group on trichloroacetimidate glycosyl donors for the synthesis of 1,2‐trans‐β‐O‐glycosides. The developed donors bearing various arming and disarming protections along with C2‐CNMe ether delivered the glycosides in short reaction time, moderate to good yields and high to excellent stereoselectivities.Gluco‐ andgalacto‐ configured donors were found compatible with an array of alcohols having varied reactivities. The orthogonality of the CNMe ether protection with silyl ether group has been further explored for sequential glycosylations.