bluuebunny/crossref_metadata_2025_split huggingface dataset:
The availability and delivery of culturally responsive Australian Aboriginal infant resuscitation education programmes: a structured literature review
Authors: Stephens Nakita , Nilson Caroline , Reibel Tracy , Marriott Rhonda 
Published: August 2023

Abstract

Aim:
To critically appraise the literature to determine availability and identify the cultural responsiveness of infant resuscitation education for Aboriginal and Torres Strait Islander populations.

Background:
Despite overall reductions in infant mortality in the last two decades, Aboriginal people have some of the highest rates of infant mortality of any developed nation. One of the key factors that has attributed to improvements in infant mortality rates is parent and carer education around risk factors and actions of first responders. Identifying gaps in the current basic first-aid initiatives available to Aboriginal communities may contribute to developing resources to contribute to reductions in Aboriginal neonatal mortality rates.

Method:
The review used key terms and Boolean operators across an 11-month time frame searching for research articles utilising the databases of CINAHL, Scopus, Ovid Emcare, Informit, Pubmed and Proquest. After review, 39 articles met the inclusion criteria, 25 articles were discarded due to irrelevant material and 14 articles were included in the structured literature review. The search process was developed using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Articles were assessed for validity and inclusion using the Critical Appraisal Skills Program checklist.

Results:
Research literature relating to First Nation community-based CPR and first-aid education programmes in Canada, USA, India, UK and Europe, Asia and Africa were identified; however, none pertaining specifically to CPR and first-aid education in Australian Aboriginal communities were found.

Discussion:
Despite the lack of research evidence relating to infant cardiopulmonary resuscitation (CPR) education for Australian Aboriginal populations, the reviewed studies noted the importance of culturally responsive education designed in collaboration with First Nation peoples, using novel ways of teaching CPR, that align with the language, culture and needs of the communities it is intended for.

Conclusion:
Further research is required to create a framework for the delivery of culturally responsive infant resuscitation education for Australian Aboriginal parents and communities.
A Pioneer in Caribbean History: Franklin Knight Reflects on Cuba
Authors: Knight Franklin W. , Guerra Lillian 
Published: August 2023

Lillian: Let's start with you telling a little about yourself.Franklin: I was born in 1942 in Jamaica. I went to elementary school, of course, and took the mandatory “Eleven-Plus” general examination in 1953. I then left elementary school and for a year attended a small private high school with my two older brothers. The school system was a little different from the United States. I know that well, because when I came here and told a group of Wisconsin school kids that I had spent six years in high school, they said, “You must have been very dumb.” To which I replied that “that was not the opinion of my teachers.” I didn't realize then that in the United States students spend four years in high school. In Jamaica we spend six, combining middle and high school years. You get in at age 12 or 13 and graduate at 18 or 19.
Toward Robust Parameterizations in Ecosystem‐Level Photosynthesis Models
Authors: Bao Shanning , Alonso Lazaro , Wang Siyuan , Gensheimer Johannes , De Ranit , Carvalhais Nuno 
Published: August 2023

AbstractIn a model simulating dynamics of a system, parameters can represent system sensitivities and unresolved processes, therefore affecting model accuracy and uncertainty. Taking a light use efficiency (LUE) model as an example, which is a typical approach for estimating gross primary productivity (GPP), we propose a Simultaneous Parameter Inversion and Extrapolation approach (SPIE) to overcome issues stemming from plant‐functional‐type (PFT)‐dependent parameterizations. SPIE refers to predicting model parameters using an artificial neural network based on collected variables, including PFT, climate types, bioclimatic variables, vegetation features, atmospheric nitrogen and phosphorus deposition, and soil properties. The neural network was optimized to minimize GPP errors and constrain LUE model sensitivity functions. We compared SPIE with 11 typical parameter extrapolating methods, including PFT‐ and climate‐specific parameterizations, global and PFT‐based parameter optimization, site‐similarity, and regression approaches. All methods were assessed using Nash‐Sutcliffe model efficiency (NSE), determination coefficient and normalized root mean squared error, and contrasted with site‐specific calibrations. Ten‐fold cross‐validated results showed that SPIE had the best performance across sites, various temporal scales and assessing metrics. Taking site‐level calibrations as a benchmark (NSE = 0.95), SPIE performed with an NSE of 0.68, while all the other investigated approaches showed lower NSE. The Shapley value, layer‐wise relevance and partial dependence showed that vegetation features, bioclimatic variables, soil properties and some PFTs determine parameters. SPIE overcomes strong limitations observed in many standard parameterization methods. We argue that expanding SPIE to other models overcomes current limits and serves as an entry point to investigate the robustness and generalization of different models.
A Bootstrap Common Mean Direction Test
Authors: Heslop David , Scealy Janice L. , Wood Andrew T. A. , Tauxe Lisa , Roberts Andrew P. 
Published: August 2023

AbstractPaleomagnetic statistical inference is underpinned by a family of parametric null hypothesis tests. In many cases, however, paleomagnetic data do not meet the distributional assumptions of these tests, which can lead to spurious inferences. Earlier studies have proposed the bootstrap as a nonparametric alternative for paleomagnetic analysis, which can be applied even when the distributional form of the data is unknown. Key among these approaches is the bootstrap test for a common mean direction, which relies on assessment of the overlap of estimated confidence regions. In its current form, the bootstrap test for a common mean paleomagnetic direction does not consider a null hypothesis and can yield outcomes that cannot be interpreted in terms of a statistical significance level. To resolve these issues, we use recent advances to place such bootstrap tests within a null hypothesis significance testing framework, and unify them with the existing family of paleomagnetic statistical tests. Furthermore, using numerical experiments we demonstrate the applicability of such a nonparametric approach to moderately sized paleomagnetic data sets typical of modern and legacy studies. Finally, we demonstrate how a confidence region can be estimated for the common mean of two sets of directions and how known directions, such as the expected field produced by a geocentric axial dipole, can be compared to that mean.
Evolution of Thrace Macula on Europa: Strike‐Slip Tectonic Control and Identification of the Youngest Terrains
Authors: Matteoni Pietro , Neesemann Alicia , Jaumann Ralf , Hillier Jon , Postberg Frank 
Published: August 2023

AbstractChaos terrains are geologically young and extensively disrupted surface features of Europa, thought to be an expression of the subsurface ocean interacting with the surface. The most prominent examples of this terrain on Europa are Conamara Chaos, and Thera and Thrace Maculae, all prime targets for the upcoming JUICE and Europa Clipper missions to assess the astrobiological potential of Europa. Of the three features, Thrace Macula is currently the least studied and understood. It intersects both Agenor Linea to the north and Libya Linea to the south, two important regional‐scale bands whose interaction with Thrace is yet to be fully unraveled, especially in terms of their relative ages of emplacement and activity. Using Galileo Solid State Imager data and Digital Terrain Models, we conducted detailed structural mapping and terrain analysis to develop a novel hypothesis on the mechanisms involved in the study area. We find that Thrace Macula is bordered along most sides by preexisting strike‐slip faults that have constrained its emplacement and areal distribution. We determine a sequence of events in the area involving the formation of Agenor Linea, followed by that of Libya Linea first and Thrace Macula later, and ultimately by strike‐slip tectonic activity likely driven by Libya Linea, that displaced a portion of Thrace Macula. Therefore, Thrace's subsurface material, uprising along faults postdating its formation, represents the freshest possible that could be sampled by future spacecraft in this region, a major consideration for the upcoming Europa Clipper mission.
Particulate Organic Matter in the Atacama Trench: Tracing Sources and Possible Transport Mechanisms to the Hadal Seafloor
Authors: Flores Edgart , Fernández‐Urruzola Igor , Cantarero Sebastian I. , Pizarro‐Koch Matías , Zabel Matthias , Sepúlveda Julio , Ulloa Osvaldo 
Published: August 2023

AbstractOceanic trenches are an important sink for organic matter (OM). However, little is known about how much of the OM reaching the hadal region derives from the sunlit surface ocean and other sources. We provide new insight into the OM sources in the Atacama Trench by examining the elemental and stable isotope composition of carbon and nitrogen in bulk OM throughout the entire water column and down to bathyal and hadal sediments. Moreover, we estimated the particulate organic carbon (POC) concentration and downward carbon flux. Our results, based on two‐way variance analysis, showed statistical differences in δ15NPON between the epipelagic zone and the deep zones. However, no statistical differences in δ13CPOC and C:N ratio between hadalpelagic and shallower pelagic zones were found, except for δ13CPOC in the oxygen‐deficient zone. On the contrary, whereas the isotopic signatures of hadal sediments were distinct from those over the entire water column, they were similar to the values in bathyal sediments. Thus, our results suggest that bathyal sediments could contribute more OM to hadal sediments than the different zones of the water column. Indeed, whereas POC flux estimates derived from remote sensing data indicate that ∼16%–27% of POC could evade surface remineralization within the top 200 m and potentially be exported to depths beyond the mesopelagic region, model estimates suggest that ∼3.3% of it could reach hadal depths. Our results provide a quantitative baseline of pelagic‐benthic coupling which can aid in assessment of carbon cycling changes in future climate scenarios.
Climate Induced Thermocline Aging and Ventilation in the Eastern Atlantic Over the Last 32,000 Years
Authors: Beisel Elvira , Frank Norbert , Robinson Laura F. , Lausecker Marleen , Friedrich Ronny , Therre Steffen , Schröder‐Ritzrau Andrea , Butzin Martin 
Published: August 2023

AbstractThe radiocarbon analysis of uranium‐thorium‐dated cold‐water corals (CWCs) provides an excellent opportunity for qualitative reconstruction of past ocean circulation and water mass aging. While mid‐depth water mass aging has been studied in the Atlantic Ocean, the evolution of the thermocline is still largely unknown. Here we present a combined 14C and 230Th/U age record obtained from thermocline dwelling CWCs at various sites in the eastern Atlantic Ocean, with intermittently centennial resolution over the last 32 ka. Shallow dwelling CWCs off Angola, located in the South Atlantic, infer a link between the mid‐depth equatorial Atlantic and Southern Ocean. They confirm a 14C drawdown during the Last Glacial Maximum (LGM) and advocate for a consistent Southern Hemisphere radiocarbon aging of upper thermocline waters, as well as strong depth gradients and high variability. Direct comparison with 14C simulations carried out with an Ocean General Circulation Model yield good agreement for Angola. In contrast, the North Atlantic thermocline shows well‐ventilated water with strong variations near the position of today's Azores Front (AF), neither of which are captured by the model. During the Bølling‐Allerød, we confirm the important role of the AF in separating North and South Atlantic thermocline waters and provide further evidence of a 500 year long deep convection interruption within the Younger Dryas (YD). We conclude that the North and South Atlantic thermocline waters were separately acting carbon reservoirs during the LGM and subsequent deglaciation until the modern circulation was established during the YD.
Multiband Metasurface‐Based Absorber for Applications in X, Ku, and K Bands
Authors: Coelho H. J. S. , Araújo B. , Silva M. W. B. , Ferreira T. N. , Campos A. L. P. S. , Junqueira C. , Kemptner Erich , Osipov Andrey 
Published: August 2023

AbstractIn this paper, a slotted‐circle patch metasurface that can efficiently absorb electromagnetic (EM) waves in three different bands is proposed. Based on the fundamental resonance of a single circular patch, EM resonances are generated making slits in the circular patch leading to multi‐band operation. Simulation results show that the proposed structure can absorb signals in three different bands, namely at 8.10, 15.39, and 19.7 GHz with absorption peaks of 99.8%, 99.7%, and 99.8%, and absorption bandwidths of 132, 181, and 90 MHz, respectively. The absorption mechanism is discussed on the basis of the single‐layer effective medium model and the analysis of surface current and electric field distributions. Furthermore, the experimental results show good agreement with the numerical simulations, with an average absorption greater than 99%. The 2‐mm thick absorber is electrically thin, corresponding to ∼λ/18 at its lowest operating frequency. Compared to other published designs, the proposed absorber has a single resonator with simple geometry, but operates in multiband. Therefore, it can be used in many applications such as anechoic chambers, scattering control, photodetectors, microbolometers, and solar cells. The proposed metasurface absorber can be used for microwave energy harvesting as well as sensor and radar cross‐section reduction applications.
Real-time programmable metasurface for terahertz multifunctional wave front engineering
Authors: Lan Feng , Wang Luyang , Zeng Hongxin , Liang Shixiong , Song Tianyang , Liu Wenxin , Mazumder Pinaki , Yang Ziqiang , Zhang Yaxin , Mittleman Daniel M. 
Published: August 2023

AbstractTerahertz (THz) technologies have become a focus of research in recent years due to their prominent role in envisioned future communication and sensing systems. One of the key challenges facing the field is the need for tools to enable agile engineering of THz wave fronts. Here, we describe a reconfigurable metasurface based on GaN technology with an array-of-subarrays architecture. This subwavelength-spaced array, under the control of a 1-bit digital coding sequence, can switch between an enormous range of possible configurations, providing facile access to nearly arbitrary wave front control for signals near 0.34 THz. We demonstrate wide-angle beam scanning with 1° of angular precision over 70 GHz of bandwidth, as well as the generation of multi-beam and diffuse wave fronts, with a switching speed up to 100 MHz. This device, offering the ability to rapidly reconfigure a propagating wave front for beam-forming or diffusively scattered wide-angle coverage of a scene, will open new realms of possibilities in sensing, imaging, and networking.
Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice
Authors: Zhang Xueying , Gao Rui , Zhang Changteng , Teng Yi , Chen Hai , Li Qi , Liu Changliang , Wu Jiahui , Wei Liuxing , Deng Liyun , Wu Lining , Ye-Lehmann Shixin , Mao Xiaobo , Liu Jin , Zhu Tao , Chen Chan 
Published: August 2023

AbstractChronic pain is often associated with cognitive decline, which could influence the quality of the patient’s life. Recent studies have suggested that Toll-like receptor 3 (TLR3) is crucial for memory and learning. Nonetheless, the contribution of TLR3 to the pathogenesis of cognitive decline after chronic pain remains unclear. The level of TLR3 in hippocampal neurons increased in the chronic constriction injury (CCI) group than in the sham group in this study. Importantly, compared to the wild-type (WT) mice, TLR3 knockout (KO) mice and TLR3-specific neuronal knockdown mice both displayed improved cognitive function, reduced levels of inflammatory cytokines and neuronal apoptosis and attenuated injury to hippocampal neuroplasticity. Notably, extracellular RNAs (exRNAs), specifically double-stranded RNAs (dsRNAs), were increased in the sciatic nerve, serum, and hippocampus after CCI. The co-localization of dsRNA with TLR3 was also increased in hippocampal neurons. And the administration of poly (I:C), a dsRNA analog, elevated the levels of dsRNAs and TLR3 in the hippocampus, exacerbating hippocampus-dependent memory. In additon, the dsRNA/TLR3 inhibitor improved cognitive function after CCI. Together, our findings suggested that exRNAs, particularly dsRNAs, that were present in the condition of chronic neuropathic pain, activated TLR3, initiated downstream inflammatory and apoptotic signaling, caused damage to synaptic plasticity, and contributed to the etiology of cognitive impairment after chronic neuropathic pain.
PRC1 suppresses a female gene regulatory network to ensure testicular differentiation
Authors: Maezawa So , Yukawa Masashi , Hasegawa Kazuteru , Sugiyama Ryo , Iizuka Mizuho , Hu Mengwen , Sakashita Akihiko , Vidal Miguel , Koseki Haruhiko , Barski Artem , DeFalco Tony , Namekawa Satoshi H. 
Published: August 2023

AbstractGonadal sex determination and differentiation are controlled by somatic support cells of testes (Sertoli cells) and ovaries (granulosa cells). In testes, the epigenetic mechanism that maintains chromatin states responsible for suppressing female sexual differentiation remains unclear. Here, we show that Polycomb repressive complex 1 (PRC1) suppresses a female gene regulatory network in postnatal Sertoli cells. We genetically disrupted PRC1 function in embryonic Sertoli cells after sex determination, and we found that PRC1-depleted postnatal Sertoli cells exhibited defective proliferation and cell death, leading to the degeneration of adult testes. In adult Sertoli cells, PRC1 suppressed specific genes required for granulosa cells, thereby inactivating the female gene regulatory network. Chromatin regions associated with female-specific genes were marked by Polycomb-mediated repressive modifications: PRC1-mediated H2AK119ub and PRC2-mediated H3K27me3. Taken together, this study identifies a critical Polycomb-based mechanism that suppresses ovarian differentiation and maintains Sertoli cell fate in adult testes.
The role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion
Authors: Yang Jian , Liu Ying , Liu Shi 
Published: August 2023

AbstractOf all pancreatic cancer (PC) cases, approximately 90% are pancreatic ductal adenocarcinoma (PDAC), which progress rapidly due to its high degree of invasiveness and high metastatic potential. Epithelial-mesenchymal transition (EMT) is a prerequisite for cancer cell invasion and spread, and it is mediated by the specific cellular behaviors and the tumor microenvironment. Autophagy has long been a target of cancer therapy, and it has been considered to play a dual and contradictory role, particularly regarding EMT-mediated PDAC invasion. This review discusses the characteristics and the biological role of EMT and autophagy from a cellular perspective, explaining invasion as a survival behavior of PDAC, with the aim of providing novel insights into targeting EMT and autophagy to overcome PDAC invasion.
A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia
Authors: Liu Zu-Qiang , Dai Hao , Yao Lu , Chen Wei-Feng , Wang Yun , Ma Li-Yun , Li Xiao-Qing , Lin Sheng-Li , He Meng-Jiang , Gao Ping-Ting , Liu Xin-Yang , Xu Jia-Xin , Xu Xiao-Yue , Wang Ke-Hao , Wang Li , Chen Luonan , Zhou Ping-Hong , Li Quan-Lin 
Published: August 2023

AbstractAchalasia is a rare motility disorder of the esophagus caused by the gradual degeneration of myenteric neurons. Immune-mediated ganglionitis has been proposed to underlie the loss of myenteric neurons. Here, we measure the immune cell transcriptional profile of paired lower esophageal sphincter (LES) tissue and blood samples in achalasia and controls using single-cell RNA sequencing (scRNA-seq). In achalasia, we identify a pattern of expanded immune cells and a specific transcriptional phenotype, especially in LES tissue. We show C1QC+ macrophages and tissue-resident memory T cells (TRM), especially ZNF683+ CD8+ TRM and XCL1+ CD4+ TRM, are significantly expanded and localized surrounding the myenteric plexus in the LES tissue of achalasia. C1QC+ macrophages are transcriptionally similar to microglia of the central nervous system and have a neurodegenerative dysfunctional phenotype in achalasia. TRM also expresses transcripts of dysregulated immune responses in achalasia. Moreover, inflammation increases with disease progression since immune cells are more activated in type I compared with type II achalasia. Thus, we profile the immune cell transcriptional landscape and identify C1QC+ macrophages and TRM as disease-associated immune cell subsets in achalasia.
Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting
Authors: Lee Eric Hee Jun , Murad John P. , Christian Lea , Gibson Jackson , Yamaguchi Yukiko , Cullen Cody , Gumber Diana , Park Anthony K. , Young Cari , Monroy Isabel , Yang Jason , Stern Lawrence A. , Adkins Lauren N. , Dhapola Gaurav , Gittins Brenna , Chang Wen-Chung , Martinez Catalina , Woo Yanghee , Cristea Mihaela , Rodriguez-Rodriguez Lorna , Ishihara Jun , Lee John K. , Forman Stephen J. , Wang Leo D. , Priceman Saul J. 
Published: August 2023

AbstractChimeric antigen receptor (CAR) T cell therapeutic responses are hampered by limited T cell trafficking, persistence, and durable anti-tumor activity in solid tumors. However, these challenges can be largely overcome by relatively unconstrained synthetic engineering strategies. Here, we describe CAR T cells targeting tumor-associated glycoprotein-72 (TAG72), utilizing the CD28 transmembrane domain upstream of the 4-1BB co-stimulatory domain as a driver of potent anti-tumor activity and IFNγ secretion. CAR T cell-mediated IFNγ production facilitated by IL-12 signaling is required for tumor cell killing, which is recapitulated by engineering an optimized membrane-bound IL-12 (mbIL12) molecule in CAR T cells. These T cells show improved antigen-dependent T cell proliferation and recursive tumor cell killing in vitro, with robust in vivo efficacy in human ovarian cancer xenograft models. Locoregional administration of mbIL12-engineered CAR T cells promotes durable anti-tumor responses against both regional and systemic disease in mice. Safety and efficacy of mbIL12-engineered CAR T cells is demonstrated using an immunocompetent mouse model, with beneficial effects on the immunosuppressive tumor microenvironment. Collectively, our study features a clinically-applicable strategy to improve the efficacy of locoregionally-delivered CAR T cells engineered with antigen-dependent immune-modulating cytokines in targeting regional and systemic disease.