bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fetal origins of obesity: a novel pathway of regulating appetite neurons in the hypothalamus of growth restricted rat offspring
Authors: Han Weiling , Song Zhaoyi , Shan Dan , Shi Qingyun 
Published: April 2023

Abstract
Purpose Fetal growth restriction causes a series of sequelae, some of which, such as hyperphagia, reduced satiety and postnatal obesity, are believed in associated with embryonic hypothalamic neurons impairment. The mechanisms underlying the linkage of fetal brain injuries to break the energy homeostasis have not been elucidated completely. Here, we aim to investigate the effect of intrauterine energy-restriction on remodeling appetite neurons in the hypothalamus of fetal and postnatal infant rats.Methods Low-protein (8%) diet combined with 75% energy restriction was used to establish an animal model. Rats offspring brain tissues, harvested from embryo day 18th and postnatal infant day 1st, were sampled for dependent regulator analyses and master neuron assessment.Results Growth restricted rats showed the increased expression of Bsx and NPY in the hypothalamus as well as remodeling hypothalamic neurons differentiation compared to controls. Intriguingly, in cells cultured in vitro test, we found that activated effects of Bsx and NPY could be exacerbated by DNMT1 inhibitor.Conclusions In embryonic and early postnatal stage of FGR rats, we detected high concentrations of orexigenic neurons in the hypothalamus. DNMT1 activity is correlated with early embryonic neurogenesis by mediating the expression of Bsx and NPY. It may be one of the reasons for the abnormal development of the appetite regulation pathway and higher susceptibility to obesity in FGR offspring.
The Determinants of CO2 Emissions in the Context of ESG Models at World Level
Authors: Costantiello Alberto , Leogrande Angelo 
Published: April 2023

Abstract
We estimate the determinants of CO2 Emissions-COE in the context of Environmental, Social and Governance-ESG model at world level. We use data of the World Bank for 193 countries in the period 2011-2020. We found that the level of COE is positively associated, among others to “Methane Emissions”, “Research and Development Expenditures”, and negatively associated among others to “Renewable Energy Consumption” and “Mean Drought Index”. Furthermore, we have applied a cluster analysis with the k-Means algorithm optimized with the Elbow Method and we find the presence of four cluster. Finally, we apply eight machine-learning algorithms for the prediction of the future value of COE and we find that the Artificial Neural Network-ANN algorithm is the best predictor. The ANN predicts a reduction in the level of COE equal to 5.69% on average for the analysed countries.
JEL Classification: D7, D70, D72, D73, D78
Effect of 2-methoxyestradiol treatment on early- and late-stage breast cancer progression in a mouse model
Authors: Peta Kimberly T. , Durandt Chrisna , Heerden Marlene B. , Joubert Anna M. , Pepper Michael S. , Ambele Melvin A. 
Published: April 2023

Abstract
BACKGROUND: The prevalence of breast cancer (BC) continues to increase and is the leading cause of cancer deaths in many countries. Numerous in vitro and in vivo studies have demonstrated that 2-methoxyestradiol (2-ME) has antiproliferative and antiangiogenic effects in BC thereby inhibiting tumour growth and metastasis. We compared the effect of 2-ME in early and late-stage BC using a transgenic mouse model – FVB/N-Tg(MMTV-PyVT) – of spontaneously development of aggressive mammary carcinoma with lung metastasis.
METHODS: Mice received 100 mg/kg 2-ME treatment immediately when palpable mammary tumours were identified (early-stage BC; experimental group 1) and 28 days after palpable mammary tumours were detected (late-stage BC; experimental group 2). 2-ME was administered via oral gavage three times a week for 28 days after initiation of treatment, while control mice received the vehicle containing 10% dimethyl sulfoxide (DMSO) and 90% sunflower oil for the same duration as the treatment group. Mammary tumours were measured weekly over the 28-day period and at termination, blood, mammary and lung tissue were collected for analysis. Mice with a tumour volume threshold of 4000mm3 were euthanized before the treatment regime was completed.
RESULTS: 2-ME treatment of early-stage BC led to lower levels of mammary tumour necrosis, while tumour mass and volume were increased. Additionally, necrotic lesions and anti-inflammatory CD163 expressing cells were more frequent in pulmonary metastatic tumours in this group. In contrast, 2-ME treatment of late-stage BC inhibited tumour growth over the 28-day period, and resulted in increased CD3+ cell number and tumour necrosis. Furthermore, 2-ME treatment slowed down pulmonary metastasis, but did not increase survival of late-stage BC mice. Besides late-stage tumour necrosis, none of the other results were statistically significant.
CONCLUSION: This study demonstrates that 2-ME treatment has an antitumour effect on late-stage BC, however with no increase in survival rate, while the treatment failed to demonstrate any benefit in early-stage BC.
Understanding the impact of along-transect resolution on acoustic surveys
Authors: Boyra Guillermo , Paradinas Iosu , Rico Iñaki , Martínez Udane , Nogueira Enrique 
Published: April 2023

Abstract
The distance between successive echosounder transmissions or “pings” is the main parameter determining the resolution of sampling along a transect in acoustic surveys. An increase in either ping interval or vessel speed increases the inter-ping distance, hence decreasing the effective resolution. In this study, we analysed whether a loss in along-transect resolution affects the mean acoustic backscattering energy, leading to uncertainty and/or bias in abundance estimates. To this end, we echo-integrated a real acoustic survey, followed by the application of a systematic resampling scheme to simulate a decrease in pinging resolution. For each transect, the mean NASC calculated at each resolution was compared with the mean NASC at the original resolution. Transects were characterised according to their heterogeneity and spatial autocorrelation to investigate their effect on the relationship between abundance error and sampling resolution. Uncertainty was seen to increase with decreasing resolution, with higher heterogeneity and lower spatial autocorrelation accelerating the rise in imprecision. Although the mean bias across replicates was zero, the asymmetry of the bias distributions increased with decreasing resolution, leading to an increasing probability and magnitude of underestimation (https://aztigps.shinyapps.io/PingRateStudio/).
Association of stress management behavior and diabetic self-care Practice among Diabetes Type II Patients in North Shoa Zone: A Cross-Sectional Study
Authors: Eshete Akine , Mohammed Sadat , Deress Tilahun , Kifleyohans Tewodros , Assefa Yibeltal 
Published: April 2023

Abstract
Background The cornerstone of managing diabetes is diabetic self-care behaviors, however many people with diabetes do not engage in enough of these actions. Effective stress management behaviors have a positive effect on diabetes self-care. The purpose of this study was to investigate the association between diabetic self-care behaviors and stress-coping behaviors in patients with type II diabetes.Method A facility-based cross-sectional study was undertaken in the North Shoa zone from February 24 to March 25, 2022. The study involved 432 types II diabetic patients who were chosen at random from eight public hospitals. Data were entered into Epi Data V.3.1 and analyzed using SPSS version 22. Data for continuous variables were reported as means of standard deviations and percentages for categorical variables. Descriptive statistic was used to summarize study variables. Binary logistic regression models were used to assess associations between sociodemographic variables, stress-coping behaviors, and self-care behaviors. In a bivariable analysis, variables with p-values less than 0.20 were put into a multivariable logistic regression model. A p-value ≤ 0.05 and an OR with a 95% CI are considered statistically significant associations.Result A total of 432 patients with type II diabetes participated with a response rate of 98%. Stress-coping behavior was observed in nearly half of the patients (51.2; 95% CI; (46.5, 55.6). The study found that stress management behavior was associated with diabetes self-care (X2, 17.7; p0.0001). Patients with good stress management behavior (AOR = 2.0, 95% CI = (1.3, 3.0)), good perception (AOR = 2.3, 95% CI = (1.5, 3.4)), and family support (AOR = 2.3, 95% CI = (1.5, 3.6)) were more likely to conduct diabetes self-care.Conclusion This study shows that stress management behaviors and coping techniques are associated with self-care behavior and lead to significant improvements in diabetes self-care practices. Stress management and coping skills should be included in current systems as a common therapeutic service/treatment and diabetes care practitioners should consider these factors when discussing diabetes self-management during consultations.
Structure of technical efficiency of insurers in the life insurance industry in Poland
Authors: Ortyński Kazimierz , Wołoszyn Jacek 
Published: April 2023

The primary objective of the article was to examine the level and efficiency structure of insurance companies on life insurance market in Poland. The study presents critical analysis of the insurance literature relating to technical efficiency of insurers, i.e. methods of estimating efficiency, the form of the efficiency frontier model, the choice of production factors and insurance production. The study used the methods of mathematical and econometric modelling in SFA method. The results the technical efficiency study for 22 life insurance companies for a period between 2011-2020 using the SFA method, showed high average cost efficiency of insurers (0.9140) and lower profit efficiency (0. 8565). It was confirmed that a group of large companies achieved higher cost efficiency than the remaining companies, suggesting that large companies benefited from the scale of production. In contrast, higher average profit efficiency was recorded for the remaining companies.
RURAL AREAS AND WINE TOURISM: THE CASE OF ROMANIA
Authors: POP Cornelia , COROS Monica Maria 
Published: April 2023

The purpose of the present paper is to provide an integrated approach to the development of wine tourism in Romania’s rural areas. The main research question is: are the communes hosting vineyards and wine-producing facilities and/or cellars/wineries in a better position to attract tourists, compared to the other communes? This question was induced, first, by the fact that Romania is among the top 15 wine producers worldwide, and some of its wine brands are (well)known at least at the regional level, hence this position might influence Romania as a wine tourism destination. Second, Romanian rural tourism is still in its early stages of development at the national level and therefore a differ­entiation feature represented by wine-related activities might enhance the attractiveness of a rural destination. Furthermore, wine tourism is a fastly developing trend at the international level and those destinations which have the resources to establish and/or improve wine tourism should take advantage of this trend. The findings of the current paper indicate that wine tourism is poorly developed for the group of wine-producing Romanian rural localities. The extra tourist potential of these localities (represented by vineyards and wineries) is used in an unsatisfactory and inexpertly manner for attracting tourists. The findings are in line with the relatively low level of rural tourism development in Romania presented by other academic works.
Article history: Received January 9, 2023; Reviewed February 13, 2023; Accepted February 20, 2023; Available online March 30, 2023; Available print April 30, 2023.
JEL Classification: Z32, L83, C10, R00.
Młode pokolenie Ukrainy jako katalizator zmian społeczno-politycznych w latach 1990–2022
Authors: Kamionka Mateusz 
Published: April 2023

Ukraina przez ponad 30 lat swojej niezależności skazana jest na nieustanną walkę o wolność. Jej położenie geograficzne na styku wielkich cywilizacji, jak i złożony kontekst historyczny, wpływa na geopolityczne zagrożenie jej niezależności. Jednak od całkowitej utraty niepodległości kosztem wschodniego sąsiada (zarówno pod kątem politycznym, jak i społecznym) Ukrainę ratowały częste protesty studenckie, które zmieniały się w rewolucje, ogarniające całe społeczeństwo. Artykuł ma na celu wykazanie wpływu młodego pokolenia na poszczególne najważniejsze wydarzenia społeczno-polityczne w Ukrainie, które to skutkowały na prozachodni kurs kraju. Autor pragnie przede wszystkim przeanalizować teksty źródłowe i opracowania naukowe, szczególnie pod kątem podkreślenia udziału młodzieży we wspomnianych wydarzeniach. Treść artykułu jednoznacznie pokazuje rolę, jaką odegrała młodzież w różnych okresach rozwoju Ukrainy, jej chęć dołączenia do stylu życia zachodnich rówieśników. To właśnie ukraińska młodzież na przestrzeni ponad 30 lat uchroniła kraj przed powrotem do ojczyzny – „nostalgii” swoich rodziców i dziadków.
Rewolucyjna niemożność. Młodzież rosyjska w świetle inwazji na Ukrainę
Authors: Bartosiewicz Miłosz 
Published: April 2023

Inwazja na Ukrainę nie spotkała się z masowym sprzeciwem ze strony rosyjskiego społeczeństwa, które zachowało się w przeważającej mierze biernie. Celem artykułu jest określenie reakcji młodego pokolenia Rosjan na wojnę, a także charakterystyka nowego podejścia władz do młodzieży. Autor dokonał analizy badań sondażowych dotyczących percepcji konfliktu na Ukrainie, prześledził przebieg protestów antywojennych w Rosji oraz zdefiniował aktualną politykę Kremla w stosunku do młodych. Mimo predysponujących do protestu cech, wyróżniających ich na tle pozostałych grup wiekowych, młodzi Rosjanie przyjęli postawę pasywną, podobnie jak reszta społeczeństwa. Władze rosyjskie podjęły szereg działań obliczonych na minimalizację potencjalnych zagrożeń płynących dla nich ze strony młodzieży. Nowy, niesformalizowany system, wdrażany w szkołach i na uczelniach wyższych, ma na celu polityczną neutralizację młodego obywatela, podporządkowanie go państwu, a także zaszczepienie w nim pożądanego przez Kreml światopoglądu.
ABORDAGENS ATUAIS DA UTILIZAÇÃO DA FIBRINA RICA EM PLAQUETAS (PRF) EM PERIODONTIA
Authors: Silva Pereira Gabrielle , Scarabello Giovanna , Tognetti Valdinéia Maria , Wiziack Zago Patricia Maria 
Published: April 2023

A periodontite compromete a perda dos tecidos de suporte e de proteção dentários e, nesse sentido, diversos biomateriais têm sido pesquisados na tentativa de se promover uma adequada neoformação tecidual. Dentre esses, a o plasma rico em fibrinas (PRF), um biomaterial de segunda geração de plaquetários, mostra-se como um promissor agente para a indução de ações regenerativas de tecidos duros e moles. Assim, essa revisão narrativa objetivou descrever as ações do PRF em periodontia a partir da busca de artigos datados de 2004 a 2020 provenientes de bases de dados do Pubmed e Scopus. Diferentes estudos clínicos e em animais reportaram a utilização do PRF sozinho ou em combinação com outro biomaterial, para o tratamento de recessões gengivais classe II de Miller, bolsas periodontais infra-ósseas e lesões de furca grau II. De acordo com os trabalhos selecionados, a utilização do PRF parece bastante promissora para o tratamento de lesões de furca grau II, mas sem vantagens em seu emprego para o tratamento de bolsas periodontais infra ósseas ou exposições radiculares. Nesse sentido, mais estudos in vivo são necessários para a validação terapêutica da utilização do PRF para diferentes tipos de defeitos periodontais.
Reclutamiento forzado un dilema real de aceptación en nuestro conflicto
Authors: Bueno Atencio Aldair 
Published: April 2023

El día 10 de marzo del año 2021, el ministro de Defensa del Gobierno colombiano, Diego Molano, manifestó ante un programa radial de escucha nacional una expresión, que generó distintos puntos de vistas, opiniones y divergencias, entre los escuchas, lectores, sectores sociales y políticos al referirse a unos menores de edad -presuntamente reclutados de manera forzada por miembros de las Farc- como “Máquinas de guerra” (Blue Radio, 2021). Con esta terminología el máximo representante del Ministerio de Defensa Nacional intentó explicar las actuaciones, las ins trucciones, pero, sobre todo, el adoctrinamiento que reciben, y al que son sometidos y sus ceptibles, los menores de edad, quienes, en el desarrollo de un conflicto armado, han sido empleados por los Grupos Armados Organizados (GAO) como un método que genera mayor impacto al momento de las confrontaciones armadas.
Estos grupos los utilizan sin tener en cuenta los más mínimos derechos humanos que le asisten a los menores de edad, los cuales son a todas luces prote gidos por el Derecho Internacional Humanitario por su edad y su vulnerabilidad, acepción que se encuentra de manera tácita al hacer referenda a la prohibición de reclutar por parte de las Fuerzas Armadas o por los grupos armados a personas menores de 18 años y la prohibición según la cual los menores de edad no deben participar en las hostilidades; premisa que no es acatada por las organizaciones armadas que los adentra en el conflicto de una manera ilógica y maquiavélica.
En tal sentido, no será el objeto del presente artículo hacer una crítica sobre la actuación del Gobierno nacional, o, si moralmente, la operación desplegada por las Fuerzas Militares fue “buena o mala”; lo que se entrará a resolver será ¿La sociedad colombiana, entiende que se encuentra directa e indirecta mente inmersa en un conflicto armado, o seguirá dando la es palda a una realidad invisible de aplicación excepcional del DIH, respecto de la participación como actores del conflicto armado de los menores reclu tados ilícita y forzadamente por miembros de los GAO?. Para ello se responderá inicialmente, al tipo de conflicto y sus formalidades tal como que se desarrolla en nuestro territorio, y por otra parte a las responsabilidades derivadas de reclutar ilícita y forzadamente a menores de edad.
Aproximación comparativa a las protestas sociales en América Latina
Authors: Librado Castillo Humberto , Moreno Peláez Jesús Eduardo 
Published: April 2023

El presente artículo realiza una aproximación comparativa de las protestas en América Latina con el ánimo de comprender su comportamiento tendencial durante el período 2019 a 2021. De este modo, examina las características de estas en términos de frecuencia para los países de la región observando algunas de sus causas, así como sus formas de manifestación; a su vez, examina las características de los actores relacionados con las movilizaciones para el lapso estudiado observando qué tipos de actores resultan comunes a las protestas regionales y cuáles hacen parte de las particularidades de cada país. Finalmente, se intenta ver cuáles son los principales grupos de demandas y la viabilidad de estas en el marco de las condiciones actuales de los Estados de la región y sus retos ligados a la globalización.
Mistikasi dalam Urban Legend: Film Horor di Indonesia Pasca Orde
Authors: Kurnaiawan Yusuf 
Published: April 2023

Tujuan penelitian ini adalah menjabarkan pergulatan pembuatan film horor berupa kelahiran dan perkembangannya pada masa pasca Orde Baru. Film horor pasca Orde Baru mengambil latar perkotaan dan menggunakan tokoh atau sosok profesional, atau pelajar muda dengan wajah yang semakin menarik. Hal ini berbanding terbali dengan film horor sebelumnya, yang menggunakan legenda atau cerita rakyat lokal (lokal). Dalam film horor Pasca Orde Baru, karakter hantuhadir di hadapan publik dalam teror psikologis. Selain itu, hampir seluruh alur cerita, kisah terjadi dalam kehidupan sehari-hari dan menjadi bagian dari kepercayaan masyarakat (legenda) kota, atau mitos legenda urban (urban legend). Salah satu film masa ini adalah berjudul, Jelangkung. Film ini menandai maraknya kembali film horor sejak era Reformasi. Gambar-gambar dalam film ini diambil dengan gaya video musik televisi Film horor Indonesia pasca Orde Baru merupakan salinan yang menarik dari perjuangan antara "tradisi" dan "modern", atau antara "alasan" dan "irasionalitas", yang membawa kepercayaan pada hal-hal mistis menjadi bagian dari kehidupan, dan terus tumbuh dalam masyarakat urban yang dianggap modern dan rasional.
Kata kunci: Orde Baru, teror psikologis, Jelangkung, tradisi, modern
Elly Kasim dan Perubahan Sosial: Analisis LIrik Lagu Minangkabau dalam Album Top Hits (1960-1970)
Authors: Novi Yulia  
Published: April 2023

Lirik-lirik lahir dari satu masa menjadi alat revitalisasi budaya di satu masyarakat. Lirik lagu Minangkabau dan penggunaan tahun dalam judul tulisan menunjukkan masa populernya lagu-lagu tersebut dan fase penting dari transisi dan transformasi masyarakat Minangkabau. Penelitian ini menunjukkan perubahan masyarakat Minangkabau dan gambaran realitas sosial-budaya Minangkabau dalam empat isu utama yaitu rantau, nilai dan norma, revitalisasi budaya, dan perubahan sosial dalam lirik lagu yang dinyanyikan Elly Kasim dalam Album Top Hits 1960-1970.
kata kunci
Revitalisasi budaya, lirik lagu, transisi, transformasi, perubahan sosial
SINKRETISASI SIWA-BUDDHA DI PURA YEH GANGGA DESA PEREAN TENGAH KECAMATAN BATURITI KABUPATEN TABANAN
Authors: Joniarta Made 
Published: April 2023

Penelitian ini dilakukan atas ketertarikan penulis terhadap studi Teologi Kerukunan yang ada di Bali. Kerukunan antar umat beragama ditengah Pulau Bali, bukan hanya di pengaruhi oleh konsensus nasional tentang stabilitas politik dan sosial, tetapi juga karena kearifan lokal tentang Sinkretisasi dalam aspek agama. Ajaran Siwa yang mendominasi dan diakui sebagai aliran mayoritas dan bahkan menjiwai sebagian besar nilai Hindu di Bali tak lupa pula mengakomodasi dan mengharmonisasi diri engan ajaran lain,salah satunya aliran Buddha. dari hal tersebut, eksistensi ajaran Buddha masih berkembang hingga saat ini. Refleksi penyatuan nilai ajaran Siwa-Buddha salah satunya dapat ditemukan di Pura yeh Gangga Desa Perean Tengah. Terdapat tiga permasalahan yang dibahas dalam penelitian ini yaitu, (1) Proses Sinkretisasi Ajaran Siwa-Buddha di Pura Yeh Gangga, (2) Faktor pendorong terjadinya Sinkretisasi Ajaran Siwa-Buddha, (3) Implikasi dari Sinkretisasi ajaran Siwa-Buddha di Pura Yeh Gangga. Teori yang digunakan untuk membedah rumusan masalah pada penelitian ini adalah teori Evolusi Sosial Budaya Durkheim untuk membedah permasalahan mengenai Proses Sinkretisasi Ajaran Siwa-Buddha di Pura Yeh gangga dan juga untuk membedah permasalahan mengenai Faktor pendorong terjadinya Sinkretisasi Ajaran Siwa-Buddha dan teori Interaksionalisme Simbolik dari Hebert Blumer membedah masalah Implikasi dari Sinkretisasi ajaran Siwa-Buddha di Pura Yeh gangga. Penelitian ini adalah penelitian lapangan kualitatif deskriptif. Sumber data primer dalam penelitian ini pada Pura Yeh gangga dan umat Hindu dan Buddha sebagai pengempon. Pengumpulan data dilakukan dengan menggunakan teknik snow ball. Hasil penelitian ini telah terjadi Sinkretisasi Ajaran Siwa-Buddha di Pura Yeh gangga meliputi (1) sejarah penyatuan Siwa-Buddha, (2) kedatangan ajaran Siwa-Buddha di Desa Perean Tengah, (3) Proses Sinkretisasi Ajaran Siwa-Buddha, dan (4) Meru Tumpang Pitu sebagai wujud Sinkretisasi. Faktor pendorong terjadinya Sinkretisasi meliputi (1) Faktor Sistem Religi, (2) Faktor Sosial. Implikasi Sinkretisasi Ajaran Siwa-Buddha di Pura Yeh gangga meliputi (1) Implikasi Sosial dan (2) Implikasi Teologis.

Kata Kunci: Sinkretisasi; Siwa-Buddha; Pura Yeh gangga.