bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Uplift of an Early Stage Collisional Plateau Unraveled by Fluvial Network Analysis and River Longitudinal Profile Inversion: The Case of the Eastern Anatolian Plateau
Authors: Molin Paola , Sembroni Andrea , Ballato Paolo , Faccenna Claudio 
Published: July 2023

AbstractOrogenic plateaus of continental collision zones exhibit landforms and fluvial networks that retain first‐order information on their topographic evolution and vertical growth. The inversion of river longitudinal profiles allows to reconstruct the base level fall history of plateaus, supporting the study of landscape evolution in the frame of geodynamic models. The Eastern Anatolian Plateau (EAP) of the Arabia‐Eurasia collision zone is a plateau at an early stage of development. It stands at ∼2,000 m, presents endorheic basins, and is drained by three main river networks. Seismic data indicate a thinned lithospheric mantle that explains the late Cenozoic volcanic activity. Despite the number of studies on the EAP uplift, its history is still debated. In this study we investigated the EAP hydrography and topography, and we inverted the longitudinal profile of one of the main rivers: the Arax River. The results describe a high‐standing, low‐relief plateau drained by a hydrography, controlled by active tectonics. Longitudinal profiles and χ‐plots illustrate rivers in disequilibrium with channel steepness increasing downstream. The elevation of marine deposits indicates a surface uplift of ∼2,000 m, ∼500 m of which are of residual topography. This upheaval occurred by two increases: the first one at 10–11 Ma with the opening of a slab window and the arrival of a mantle flow from Arabia and the second one at ∼5 Ma with the continued inflow coupled with isostasy. Our results describe the early stage of collisional plateau development, distinguishing the contribution of deep processes and isostasy to the topographic growth.
Molecular Epidemiology of Antimicrobial Resistance in Central Africa: A Systematic Review
Authors: DIKOUMBA Annicet-Clotaire , ONANGA Richard , MANGOUKA Laurette G. , BOUNDENGA Larson , NGOUNGOU Edgard-Brice , GODREUIL Sylvain 
Published: July 2023

Background: In Central Africa, it is difficult to fight against antibiotic resistance, because of a lack of data and information on bacterial resistance, due to the low number of studies carried out in the field. To fill this gap, we carried out a systematic review of the various studies, and devise a molecular epidemiology of antimicrobial resistance from humans, animals and the environmental samples.Method: A systematic search of all publications from 2005 to 2020 on bacterial resistance in Central Africa was performed on Pubmed, Google scholar and African journals online. All circulating resistance genes, prevalence and genetic carriers of these resistances were collected. The study area was limited to the 9 countries of Central Africa. Results: Five hundred seventeen studies were identified through a literature search, and sixty studies carried out in 8 countries were included. Among all articles included, 43 articles were from human. Our study revealed not only the circulation of beta-lactamase and carbapenemase genes, but also several other types of resistance genes. To finish, we noticed that some studies reported mobile genetic elements such as integrons, transposons, plasmids, or chromosomes.Conclusion: The scarcity of data poses difficulties in the implementation of effective strategies in the fight against antibiotic resistance, which requires a health policy in a "One Health" approach.
Risk and ambiguity of COVID-19 inhibit intentions for post-pandemic travel via reduced valuation of tourism
Authors: Ye Baojuan , Zhao Shunying , Im Hohjin , Gan Liluo , Liu Mingfan , Wang Xinqiang , Yang Qiang 
Published: July 2023

PurposeThis study aims to examine how the initial ambiguity of COVID-19 contributed to tourists' intentions for visiting a once-viral outbreak site in the future.Design/methodology/approachThe present study (N = 248) used partial least-squares structural equation modeling (PLS-SEM) to examine whether perceptions of ambiguity and mismanagement of COVID-19 are indirectly related to intentions to travel to Wuhan in a post-pandemic world through perceptions of risk and tourism value. Further, whether the model effects differed as a function of individual safety orientation was examined.FindingsPerceptions of COVID-19 risk and tourism value serially mediated the effects of perceived COVID-19 ambiguity on post-pandemic travel intentions. Safety orientation did not moderate any paths. Perceived risk was a negative direct correlate of post-pandemic travel intentions.Originality/valueThe current study's strength is rooted in its specific targeting of post-pandemic travel intentions to Wuhan—the first city to experience a widescale outbreak of COVID-19 and subsequent international stigma—compared to general travel inclinations.
Integrating Pool‐seq uncertainties into demographic inference
Authors: Carvalho João , Morales Hernán E. , Faria Rui , Butlin Roger K. , Sousa Vítor C. 
Published: July 2023

AbstractNext‐generation sequencing of pooled samples (Pool‐seq) is a popular method to assess genome‐wide diversity patterns in natural and experimental populations. However, Pool‐seq is associated with specific sources of noise, such as unequal individual contributions. Consequently, using Pool‐seq for the reconstruction of evolutionary history has remained underexplored. Here we describe a novel Approximate Bayesian Computation (ABC) method to infer demographic history, explicitly modelling Pool‐seq sources of error. By jointly modelling Pool‐seq data, demographic history and the effects of selection due to barrier loci, we obtain estimates of demographic history parameters accounting for technical errors associated with Pool‐seq. Our ABC approach is computationally efficient as it relies on simulating subsets of loci (rather than the whole‐genome) and on using relative summary statistics and relative model parameters. Our simulation study results indicate Pool‐seq data allows distinction between general scenarios of ecotype formation (single versus parallel origin) and to infer relevant demographic parameters (e.g. effective sizes and split times). We exemplify the application of our method to Pool‐seq data from the rocky‐shore gastropod Littorina saxatilis, sampled on a narrow geographical scale at two Swedish locations where two ecotypes (Wave and Crab) are found. Our model choice and parameter estimates show that ecotypes formed before colonization of the two locations (i.e. single origin) and are maintained despite gene flow. These results indicate that demographic modelling and inference can be successful based on pool‐sequencing using ABC, contributing to the development of suitable null models that allow for a better understanding of the genetic basis of divergent adaptation.
From “disappointing” to “fantastic”: Women's experiences with labor induction in a U.S. tertiary hospital
Authors: Danilack Valery A. , Siegel‐Reamer Leah , Lum Liana , Kesselring Cailey , Brousseau Erin Christine , Guthrie Kate M. 
Published: July 2023

AbstractObjectiveThe series of interventions that comprise labor induction shape patient experiences; however, patient perceptions are not always considered when structuring the process of care. Through qualitative interviews, we elucidated women's expectations and experiences regarding labor induction.MethodsLabor induction patients were recruited from a United States tertiary care hospital's postpartum mother–baby unit and invited to participate in semi‐structured qualitative interviews. Interview questions included expectations and experiences of the labor induction process, side effects and health outcomes of concern, reflections on personal tolerance of different interventions, and thoughts about an ideal process.ResultsBetween April and September 2018, 36 women were interviewed. The labor induction process involved a wide range of experiences; when asked to characterize labor induction in one word, responses ranged from horrible, frustrating, and terrifying to simple, fast, and smooth. Inductions were often described as longer than what was expected. The most polarizing induction method was the Foley balloon catheter. Women's concerns regarding side effects largely centered on the health of their baby, and an ideal induction involved fewer interventions.ConclusionsExperiences with labor induction vary greatly and are related to expectations. The way interventions are introduced influences women's perceptions of control and their ultimate level of contentment with the birthing process. Attention to experiences and preferences has the potential to improve quality of care through communication, shared decision‐making, and education.
Functions of actin‐binding proteins in cilia structure remodeling and signaling
Authors: Wang Siqi , Wang Xin , Pan Congbin , Liu Ying , Lei Min , Guo Xiying , Chen Qingjie , Yang Xiaosong , Ouyang Changhan , Ren Zhanhong 
Published: July 2023

AbstractCilia are microtubule‐based organelles found on the surfaces of many types of cells, including cardiac fibroblasts, vascular endothelial cells, human retinal pigmented epithelial‐1 (RPE‐1) cells, and alveolar epithelial cells. These organelles can be classified as immotile cilia, referred to as primary cilia in mammalian cells, and motile cilia. Primary cilia are cellular sensors that detect extracellular signals; this is a critical function associated with ciliopathies, which are characterized by the typical clinical features of developmental disorders. Cilia are extensively studied organelles of the microtubule cytoskeleton. However, the ciliary actin cytoskeleton has rarely been studied. Clear evidence has shown that highly regulated actin cytoskeleton dynamics contribute to normal ciliary function. Actin‐binding proteins (ABPs) play vital roles in filamentous actin (F‐actin) morphology. Here, we discuss recent progress in understanding the roles of ABPs in ciliary structural remodeling and further downstream ciliary signaling with a focus on the molecular mechanisms underlying actin cytoskeleton‐related ciliopathies.
Targeting the loss of cGAS/STING signaling in cancer
Authors: Sasaki Nobunari , Homme Mizuki , Kitajima Shunsuke 
Published: July 2023

AbstractThe cGAS/STING pathway provides a key host defense mechanism by detecting the accumulation of cytoplasmic double‐stranded DNA (dsDNA) and mediating innate and adaptive immune signaling. In addition to detecting pathogen‐derived dsDNA, cGAS senses intrinsic dsDNA, such as those associated with defective cell cycle progression and mitophagy that has leaked from the nucleus or mitochondria, and subsequently evokes host immunity to eliminate pathogenic cells. In cancer cells, dysregulation of DNA repair and cell cycle caused at the DNA replication checkpoint and spindle assembly checkpoint results in aberrant cytoplasmic dsDNA accumulation, stimulating anti‐tumor immunity. Therefore, the suppression of cGAS/STING signaling is beneficial for survival and frequently observed in cancer cells as a way to evade detection by the immune system, and is likely to be related to immune checkpoint blockade (ICB) resistance. Indeed, the mechanisms of ICB resistance overlap with those acquired in cancers during immunoediting to evade immune surveillance. This review highlights the current understanding of cGAS/STING suppression in cancer cells and discusses how to establish effective strategies to regenerate effective anti‐tumor immunity through reactivation of the cGAS/STING pathway.
Exploring the role of a facilitator in supporting family carers when embedding the iSupport for Dementia programme in care services: A qualitative study
Authors: Yu Ying , Hunter Sarah C. , Xiao Lily , Meyer Claudia , Chapman Michael , Tan Kai Ping , Chen Langduo , McKechnie Sue , Ratcliffe Julie , Ullah Shahid , Kitson Alison , Andrade Andre Q. , Whitehead Craig 
Published: July 2023

AbstractAimsTo explore stakeholders' perceptions of a facilitator's role in supporting carers when embedding iSupport for Dementia psychoeducation program, in care services.MethodsA qualitative descriptive study design was applied. Data were collected from workshops and interviews with carers of people living with dementia (PLWD)and with health and social care professionals from two tertiary hospitals and two community aged care organisations across three Australian states between October 2021 and March 2022. A thematic analysis was used to analyse data. The COREQ guideline was followed to report our findings.ResultsA total of 30 family carers and 45 health and social care professionals participated in the study. Three main themes and seven subthemes were identified from the data. We described the main themes as (1) the facilitator's role at the time of dementia diagnosis, (2) the facilitator's role throughout the everyday dementia care journey and (3) the facilitator's role during transition moments.ConclusionsCaring for family members with dementia is demanding and stressful for carers. Embedding a facilitator‐enabled iSupport for Dementia program in hospital and community aged care settings has the potential to mitigate sources of stress associated with care recipient factors, carer factors and care service factors, and improve the health and well‐being of carers and those for whom they care.Relevance to Clinical PracticeOur findings will inform the establishment of iSupport facilitators appointed by dementia care providers in hospital and community care settings and help determine their roles and responsibilities in delivering the iSupport program. Our findings relate to nurse‐led and coordinated dementia care in hospital and community aged care settings.Patient or Public ContributionThis study was co‐designed with stakeholders from two aged care organisations and two tertiary hospitals. The study participants were staff employed by these organisations and carers of PLWD who were service users.
“Cross Treaty Interpretation” en bloc or How CAFTA-DR Tribunals Are Systematically Interpreting the FET Standard Based on NAFTA Case Law
Authors: Dumberry Patrick 
Published: July 2023

Abstract
This article examines how tribunals set up under the CAFTA-DR have interpreted the fair and equitable treatment (‘FET’) standard under Article 10.5 in the last 15 years. It shows that they have consistently referred to NAFTA case law to define the standard and to interpret the scope and content of the different elements it contains (arbitrary conduct, legitimate expectations, due process). The only exception is regarding denial of justice. This is a fascinating example of “cross treaty interpretation”. I will explain the reasons why CAFTA tribunals have done so and examine whether or not this “cross treaty interpretation” en bloc is legitimate and sound in light of the canons of treaty interpretation.
Moving Away from Open Judicial Balancing Review
Authors: Gerards Janneke 
Published: July 2023

Abstract
The Covid-19 pandemic truly has been called a global crisis. To fight the spread of the virus, many States have introduced measures that seriously restrict or affect fundamental rights, ranging from procedural rights to the freedom of movement and the right to personal autonomy. In Europe, it is to be expected that many cases concerning such rights infringements eventually will come before the European Court of Human Rights (ECtHR). This contribution aims to give an insight into how the Court will likely give shape to its proportionality test in such cases. It thereby predicts that open balancing review – for which the ECtHR is famous – will play a much less important role than methods of reasoning by analogy and procedural review.
SETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapy
Authors: Zheng Xiaobin , Lin Jing , Xiong Jiani , Guan Yanfang , Lan Bin , Li Yi , Gao Xuan , Fei Zhaodong , Chen Lisha , Chen Lizhu , Chen Ling , Chen Gang , Guo Zengqing , Yi Xin , Cao Weiguo , Ai Xinghao , Zhou Chengzhi , Li Xiaofeng , Zhao Jun , Yan Xiangtao , Yu Qitao , Si Lu , Chen Yu , Chen Chuanben 
Published: July 2023

Abstract
Background
SETD2 protects against genomic instability via maintenance of homologous recombination repair (HRR) and mismatch repair (MMR) in neoplastic cells. However, it remains unclear whether SETD2 dysfunction is a complementary or independent factor to microsatellite instability-high (MSI-H) and tumor mutational burden-high (TMB-H) for immunocheckpoint inhibitor (ICI) treatment, and little is known regarding whether this type of dysfunction acts differently in various types of cancer.

Methods
This cohort study used multidimensional genomic data of 6726 sequencing samples from our cooperative and non-public GenePlus institute from April 1 through April 10, 2020. MSIsensor score, HRD score, RNAseq, mutational data, and corresponding clinical data were obtained from the TCGA and MSKCC cohort for seven solid tumor types.

Results
A total of 1021 genes underwent target panel sequencing reveal that SETD2 mutations were associated with a higher TMB. SETD2 deleterious mutation dysfunction affected ICI treatment prognosis independently of TMB-H (p < 0.01) and had a lower death hazard than TMB-H in pancancer patients (0.511 vs 0.757). Significantly higher MSI and lower homologous recombination deficiency were observed in the SETD2 deleterious mutation group. Improved survival rate was found in the MSKCC-IO cohort (P < 0.0001) and was further confirmed in our Chinese cohort.

Conclusion
We found that SETD2 dysfunction affects ICI treatment prognosis independently of TMB-H and has a lower death hazard than TMB-H in pancancer patients. Therefore, SETD2 has the potential to serve as a candidate biomarker for ICI treatment. Additionally, SETD2 should be considered when dMMR is detected by immunohistochemistry.
Colloidal Trehalose Nanoparticles: Sacrifice Templates for Hollow Silica Nanospheres
Authors: Matsune Hideki , Ikemizu Ren , Shiomori Koichiro , Muraoka Emi , Yamamoto Tsuyoshi , Kishida Masahiro 
Published: July 2023

Abstract
We demonstrate a trehalose nanoparticle (Tre NP) colloid first prepared by an injection method, and applied to a sacrifice template to create a hollow silica nanosphere. The Tre NP is successfully coated with a uniform layer of silica via sol-gel process, and removed simply by soaking in water, leading to the formation of the hollow nanostructure.
Association of indoor use of pesticides with CKD of unknown origin
Authors: Alvand Saba , Alatab Sudabeh , Dalvand Sahar , Shahraki-Sanavi Fariba , Kaykhaei Mahmoud Ali , Shahraki Elham , Barar Erfaneh , Sepanlou Sadaf G. , Ansari-Moghaddam Alireza 
Published: July 2023

Introduction
Chronic kidney disease (CKD) is a growing global health problem. Recently, an epidemic of CKD of unknown origin (CKDu), a form of CKD seen mostly in agricultural communities, has been emerged. One of the proposed causes of CKDu is pesticide use in farmers. On the other hand, the research on relation between indoor use of pesticides and CKDu is little. In this study, we aimed to investigate the association between indoor use of pesticide as well as the exposure time with CKDu. This study was done as part of the population-based cohort of Prospective Epidemiological Research Studies in Iran. We used the baseline data of the Zahedan Adult Cohort Study. All subjects with diabetes mellitus and/or hypertension, estimated glomerular filtration rate (eGFR) between 60–89 ml/min/1.73 m2, and unavailable creatinine measurement were excluded. Subjects with an eGFR of less than 60 ml/min/1.73 m2 were defined as having CKDu, and their data were compared with those with an eGFR of more than 90 ml/min/1.73 m2. Data regarding indoor pesticide use and duration of exposure were obtained through a questionnaire. After applying the exclusion criteria, 1079 subjects remained in the study. Female sex, single marital status, low physical activity, triglyceride (TG) levels of more than 150 mg/dl, body mass index (BMI) of more than 25 kg/m2, non-smokers, indoor pesticide use, and high pesticide exposure time were associated with CKDu. The effects of age, female sex, TG levels more than 150 mg/dl, pesticide use (OR 1.36; 95% CI 1.01–1.84), and high exposure time (third tertile of exposure time) compared to non-users (OR 1.64; 95% CI 1.07–2.51) remained significant in multivariable analysis.

Conclusion
We found a positive association between pesticide use, as well as longer exposure time to pesticides, and impaired kidney function in cases without diabetes mellitus and hypertension. Further longitudinal studies should be carried out to confirm these findings.
Comparison of oral versus intravenous methadone on postoperative pain and opioid use after adult spinal deformity surgery: A retrospective, non-inferiority analysis
Authors: Esfahani Kamilla , Tennant William , Tsang Siny , Naik Bhiken I. , Dunn Lauren K. 
Published: July 2023

Objective
To compare efficacy of oral versus intravenous (IV) methadone on postoperative pain and opioid requirements after spine surgery.

Methods
This was a retrospective, single-academic center cohort study evaluating 1010 patients who underwent >3 level spine surgery from January 2017 to May 2020 and received a one-time dose of oral or intravenous methadone prior to surgery. The primary outcome measured was postoperative opioid use in oral morphine equivalents (ME) and verbal response scale (VRS) pain scores up to postoperative day (POD) three. Secondary outcomes were time to first bowel movement and adverse effects (reintubation, myocardial infarction, and QTc prolongation) up to POD 3.

Results
A total of 687 patients received oral and 317 received IV methadone, six patients were excluded. The IV group received a significantly greater methadone morphine equivalent (ME) dose preoperatively (112.4 ± 83.0 mg ME versus 59.3 ± 60.9 mg ME, p < 0.001) and greater total (methadone and non-methadone) opioid dose (119.1 ± 81.4 mg ME versus 63.9 ± 62.5 mg ME, p < 0.001), intraoperatively. Although pain scores for the oral group were non-inferior to the IV group for all postoperative days (POD), non-inferiority for postoperative opioid requirements was demonstrated only on POD 3. Based on the joint hypothesis for the co-primary outcomes, oral methadone was non-inferior to IV methadone on POD 3 only. No differences in secondary outcomes, including QTc prolongation and arrhythmias, were noted between the groups.

Conclusions
Oral methadone is a feasible alternative to IV methadone for patients undergoing spine surgery regarding both pain scores and postoperative opioid consumption.