bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 surge readiness: use cases demonstrating how hospitals leveraged digital identity access management for infection control and pandemic response
Authors: Gellert George A , Kelly Sean P , Hsiao Allen L , Herrick Brian , Weis Donna , Lutz Jeffrey , Stanton Glynn , Bonilla Santos , Borgasano Daniel , Erich Matthew , Reilly Claire , Johnston Daniel 
Published: February 2023

BackgroundSurging volumes of patients with COVID-19 and the high infectiousness of SARS-CoV-2 challenged hospital infection control/safety, staffing, care delivery and operations as few crises have. Imperatives to ensure security of patient information, defend against cybersecurity threats and accurately identify/authenticate patients and staff were undiminished, which fostered creative use cases where hospitals leveraged identity access and management (IAM) technologies to improve infection control and minimise disruption of clinical and administrative workflows.MethodsWorking with a leading IAM solution provider, implementation personnel in the USA and UK identified all hospitals/health systems where an innovative use of IAM technology improved facility infection control and pandemic response management. Interviews/communications with hospital clinical informatics leaders collected information describing the use case deployed.ResultsEight innovative/valuable hospital use cases are described: symptom-free attestation by clinicians at shift start; detection of clinician exposure/contact tracing; reporting of clinician temperature checks; inpatient telehealth consults in isolation units; virtual visits between isolated patients and families; touchless single sign-on authentication; secure access enabled for rapid expansion of personnel working remotely; and monitoring of temporary worker attendance.DiscussionNo systematic, comprehensive survey of all implemented IAM client sites was conducted, and other use cases may be undetected. A standardised reporting/information sharing vehicle is needed whereby IAM use cases aiding facility pandemic response and infection control can be disseminated.ConclusionsClinical care, infection control and facility operations were improved using IAM solutions during COVID-19. Facility end-user innovation in how IAM solutions are deployed can improve infection control/patient safety, care delivery and clinical workflows during surges of epidemic infectious diseases.
Opti’care protocol: a randomised control trial to evaluate the impact of a mobile antenatal care clinic in isolated rural areas on prenatal follow-up
Authors: Debost-Legrand Anne , Legrand Guillaume , Duclos-Médard Julie , Thomazet Juliette , Pranal Marine , Langlois Eric , Mourgues Charline , Vendittelli Françoise 
Published: February 2023

IntroductionRural residence appears to be a factor of vulnerability among pregnant women with poor clinical antenatal care. Our principal objective is to assess the impact of an infrastructure for a mobile antenatal care clinic on the completion of antenatal care for women identified as geographically vulnerable in a perinatal network.Methods and analysisControlled cluster-randomised study in two parallel arms comparing an intervention group with an open-label control group. This study will concern the population of pregnant women who must live in one of the municipalities covered by the perinatal network and considered to be an area of geographic vulnerability. The cluster randomisation will take place according to the municipality of residence. The intervention will be the implementation of pregnancy monitoring by a mobile antenatal care clinic. The completion of antenatal care between the intervention and control groups will be a binary criterion: 1 will be attributed to each antenatal care that includes all visits and supplementary examinations. Sample size has been estimated to be 330 at least with an 80% participation rate.The univariate analyses will compare the follow-up rates (with Fisher’s exact test), and all individual characteristics collected (Fisher’s exact test, Student’s t-test) between the two groups. The multivariate analysis will use a mixed linear model analysis and consider the cluster effect as random; the initial model will include known confounders from the literature, confounders identified in univariate analyses, and the clinically relevant prognostic factors. All of these factors will be taken into account in the model as a fixed effect.Ethics and disseminationThe Patient Protection Committee North-West II approved this study on 4 February 2021 (IRB 2020-A02247-32). The results will be the subject of scientific communications and publications.Trial registration numberNCT04823104.
Factors associated with severity and persistence of fatigue in patients with primary biliary cholangitis: study protocol of a prospective cohort study with a mixed-methods approach (SOMA.LIV)
Authors: Toussaint Anne , Buck Laura , Hartl Johannes , Löwe Bernd , Schramm Christoph 
Published: February 2023

IntroductionFatigue is a common symptom and the major ‘unmet need’ in the management of patients with primary biliary cholangitis (PBC). To date, only few prospective studies have addressed the development of PBC-associated fatigue over time. At the same time, few biological and psychosocial risk factors and mechanisms have been identified that could explain the development and maintenance of fatigue in PBC. It is the overall aim of this study to identify factors that determine the course and severity of fatigue in PBC, and to target these factors within deliverable interventions in order to improve patients’ quality of life.Methods and analysisTo identify biological and psychosocial risk factors for severe fatigue, a prospective 12-month cohort study with one baseline and two follow-up measurements will be conducted. In a cross-sectional part, we will simultaneously examine clinically relevant biomedical and psychosocial factors and systematically assess and compare associations and interactions between these factors and fatigue in n=240 patients with PBC (a patient group severely affected by fatigue) and n=240 patients with primary sclerosing cholangitis, a control cholestatic liver disease group much less affected by fatigue. In a prospective part, we will longitudinally monitor these variables and assess their predictive value at 12-month follow-up. Within an embedded mixed-methods design, we will conduct an experimental study and qualitative interviews in patients with newly diagnosed PBC.Ethics and disseminationThe study was approved by the Ethics Committee of the Hamburg Medical Association (2020–10196-BO-ff). The study will shed light onto the mechanisms underlying the evolvement and maintenance of fatigue in patients with PBC and enable the development of evidence-based intervention strategies. Findings will be disseminated through peer-reviewed publications, scientific conferences and the involvement of relevant stakeholders, patients and the lay public.Trial registration numberNCT14379650.
Protocol for a process evaluation of a stepped wedge randomised controlled trial to reduce unnecessary hospitalisations of older people from residential aged care: the EDDIE+ study
Authors: Bracci Ella , Allen Michelle , Carter Hannah E , Cyarto Liz , Dwyer Trudy , Graves Nicholas , Lee Xing Ju , Meyer Claudia , Oprescu Florin , Harvey Gillian 
Published: February 2023

IntroductionThe Early Detection of Deterioration in Elderly residents (EDDIE+) programme is a theory-informed, multi-component intervention aimed at upskilling and empowering nursing and personal care staff to identify and manage early signs of deterioration in residents of aged care facilities. The intervention aims to reduce unnecessary hospital admissions from residential aged care (RAC) homes. Alongside a stepped wedge randomised controlled trial, an embedded process evaluation will be conducted to assess the fidelity, acceptability, mechanisms of action and contextual barriers and enablers of the EDDIE+ intervention.Methods and analysisTwelve RAC homes in Queensland, Australia are participating in the study. A comprehensive mixed-methods process evaluation, informed by the integrated Promoting Action on Research Implementation in Health Services (i-PARIHS) framework, will assess intervention fidelity, contextual barriers and enablers, mechanisms of action, and the acceptability of the programme from various stakeholder perspectives. Quantitative data will be collected prospectively from project documentation, including baseline context mapping of participating sites, activity tracking and regular check-in communication sheets. Qualitative data will be collected postintervention via semi-structured interviews with a range of stakeholder groups. The i-PARIHS constructs of innovation, recipients, context and facilitation will be applied to frame the analysis of quantitative and qualitative data.Ethics and disseminationEthical approval for this study has been granted by the Bolton Clarke Human Research Ethics Committee (approval number: 170031) with administrative ethical approval granted by the Queensland University of Technology University Human Research Ethics Committee (2000000618). Full ethical approval includes a waiver of consent for access to residents’ demographic, clinical and health services de-identified data. A separate health services data linkage based on RAC home addresses will be sought through a Public Health Act application. Study findings will be disseminated through multiple channels, including journal publications, conference presentations and interactive webinars with a stakeholder network.Trial registration numberAustralia New Zealand Clinical Trial Registry (ACTRN12620000507987).
Efficacy and safety of transcutaneous electrical acupoints stimulation for preoperative anxiety in thoracoscopic surgery: study protocol for a randomised controlled trial
Authors: Wu Xindi , Chen Tongyu , Wang Ke , Wei Xuqiang , Feng Jijie , Zhou Jia 
Published: February 2023

IntroductionPreoperative anxiety occurs at a very high rate in patients undergoing video-assisted thoracoscopic surgery (VATS). Moreover, it will result in poor mental state, more analgesic consumptions, rehabilitation delay and extra hospitalisation costs. Transcutaneous electrical acupoints stimulation (TEAS) is a convenient intervention for pain control and anxiety reduction. Nevertheless, TEAS efficacy of preoperative anxiety in VATS is unknown.Methods and analysisThis single-centre randomised sham-controlled trial will be conducted in cardiothoracic surgery department of the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine in China. A total of 92 eligible participants with pulmonary nodules (size ≥8 mm) who are arranged for VATS will be randomly assigned to a TEAS group and a sham TEAS (STEAS) group in a 1:1 ratio. Daily TEAS/STEAS intervention will be administered starting on 3 days before the VATS and continued once per day for three consecutive days. The primary outcome will be the generalised anxiety disorder scale score change between the day before surgery with the baseline. The secondary outcomes will include serum concentrations of 5-hydroxytryptamine, norepinephrine and gamma-aminobutyric acid, intraoperative anaesthetic consumption, time to postoperative chest tube removal, postoperative pain, and length of postoperative hospital stay. The adverse events will be recorded for safety evaluation. All data in this trial will be analysed by the SPSS V.21.0 statistical software package.Ethics and disseminationEthics approval was obtained from the Ethics Committee of the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine (approval number: 2021-023). The results of this study will be distributed through peer-reviewed journals.Trial registration numberNCT04895852.
Linking electronic mental healthcare and benefits records in South London: design, procedure and descriptive outcomes
Authors: Stevelink Sharon A M , Phillips Ava , Broadbent Matthew , Boyd Andy , Dorrington Sarah , Jewell Amelia , Leal Ray , Bakolis Ioannis , Madan Ira , Hotopf Matthew , Fear Nicola T , Downs Johnny 
Published: February 2023

ObjectivesTo describe the process and outcomes of a data linkage between electronic secondary mental healthcare records from the South London and Maudsley (SLaM) NHS Foundation Trust with benefits records from the Department for Work and Pensions (DWP). We also describe the mental health and benefit profile of patients who were successfully linked.DesignA deterministic linkage of routine records from health and welfare government service providers within a secure environment.Setting and participantsAdults aged≥18 years who were referred to or accessed treatment at SLaM services between January 2007 and June 2019, including those who were treated as part of Improving Access to Psychological Therapies (IAPT) services between January 2008 and June 2019 (n=448 404). Benefits data from the DWP from January 2005 to June 2020.Outcome measuresThe linkage rate and associated sociodemographic, diagnostic and treatment factors. Recorded primary psychiatric diagnosis based on International Classification of Diseases (ICD)-10 codes and type of benefit receipt.ResultsA linkage rate of 92.3% was achieved. Women, younger patients and those from ethnic minority groups were less likely to be successfully linked. Patients who had subsequently died, had a recorded primary psychiatric diagnosis, had also engaged with IAPT and had a higher number of historical postcodes available were more likely to be linked. Overall, 83% of patients received benefits at some point between 2005 and 2020. Benefit receipt across the psychiatric diagnosis spectrum was high, over 80% across most ICD-10 codes.ConclusionsThis data linkage is the first of its kind in the UK demonstrating the use of routinely collected mental health and benefits data. Benefit receipt was high among patients accessing SLaM services and varied by psychiatric diagnosis. Future areas of research are discussed, including exploring the effectiveness of interventions for helping people into work and the impact of benefit reforms.
Does systematic analysis of patient complaints and compensation cases at hospitals provide useful information to guide quality improvement? Experience from Denmark
Authors: Morsø Lars , Birkeland Søren Fryd , Walløe Sisse , Grøn Peter Sigerseth , Rexbye Helle , Bogh Søren Bie Bie 
Published: February 2023

BackgroundPatient complaints and compensation cases are analysed individually and do not allow for organisational learning. Systematic information on complaint patterns needs evidence-based measures. The Healthcare Complaints Analysis Tool (HCAT) can systematically code and analyse complaints and compensation claims, but whether this information is useful for quality improvement is underexplored. We aim to explore if and how HCAT information is perceived useful to inform healthcare quality gaps.MethodsTo explore the HCAT’s usefulness for quality improvement purposes, we used an iterative process. We accessed all complaints relating to a large university hospital. Trained HCAT raters systematically coded all cases, using the Danish version of HCAT.InterventionThe intervention had four phases: (1) coding of cases, (2) education, (3) selection of HCAT analyses for dissemination, (4) ‘dashboard’ development and delivery of targeted HCAT reports. To study the interventions and phases, we used quantitative and qualitative approaches. The coding patterns were descriptively displayed on department and hospital level. The educational programme was monitored using passing rates, coding reliability checks and rater feedback. Online interviews recorded dissemination feedback. We used a phenomenological approach with thematised quotations from the interviews to analyse the usefulness of the information from cases coded.ResultsWe coded 5217 complaint cases (11 056 complaint points). The average case coding time was 8.5 min (95% CI 8.2 to 8.7). All four raters passed the online test with >80% correct answers. Using rater feedback, we handled 25 cases of doubt. None affected the HCAT structure or categories. Interviews verified the usefulness of analyses after expert group dissemination. Three themes were important: ‘overview of complaints’, ‘learning from complaints’ and ‘listening to the patients’. Stakeholders perceived the ‘dashboard’ development as highly relevant.ConclusionThrough the development process with several adjustments, stakeholders found the systematic approach useful for quality improvement. The hospital management evaluated the approach as promising and decided to test the approach in clinical practice.
The Design of Fast and Lightweight Resemblance Detection for Efficient Post-Deduplication Delta Compression
Authors: Xia Wen , Pu Lifeng , Zou Xiangyu , Shilane Philip , Li Shiyi , Zhang Haijun , Wang Xuan 
Published: February 2023

Post-deduplication delta compression is a data reduction technique that calculates and stores the differences of very similar but non-duplicate chunks in storage systems, which is able to achieve a very high compression ratio. However, the low throughput of widely used resemblance detection approaches (e.g., N-Transform) usually becomes the bottleneck of delta compression systems due to introducing high computational overhead. Generally, this overhead mainly consists of two parts: ① calculating the rolling hash byte by byte across data chunks and ② applying multiple transforms on all of the calculated rolling hash values.

In this article, we propose Odess, a fast and lightweight resemblance detection approach, that greatly reduces the computational overhead for resemblance detection while achieving high detection accuracy and a high compression ratio. Odess first utilizes a novel Subwindow-based Parallel Rolling (SWPR) hash method using Single Instruction Multiple Data [
1
] (SIMD) to accelerate calculation of rolling hashes (corresponding to the first part of the overhead). Odess then uses a novel Content-Defined Sampling method to generate a much smaller proxy hash set from the whole rolling hash set and quickly applies transforms on this small hash set for resemblance detection (corresponding to the second part of the overhead).

Evaluation results show that during the stage of resemblance detection, the Odess approach is ∼31.4× and ∼7.9× faster than the state-of-the-art N-Transform and Finesse (a recent variant of N-Transform [
39
]), respectively. When considering an end-to-end data reduction storage system, the Odess-based system’s throughput is about 3.20× and 1.41× higher than the N-Transform- and Finesse-based systems’ throughput, respectively, while maintaining the high compression ratio of N-Transform and achieving ∼1.22× higher compression ratio over Finesse.
Floristic Composition and Structural Analysis of Woody Plant Species in Jib Godo Natural Forest, Farta District, South Gonder Zone, Amhara Region, Ethiopia
Authors: Wubu Kassaw Awoke , Matavan Ramaraj Elango , Anteneh Endale Adamu 
Published: February 2023

Afromontane forests are crucial for maintaining plant diversity and reducing climate change. Even though the Jib Godo Natural Forest is subject to anthropogenic impacts such as cutting and farming, it lacks long-term conservation practices. The researchers conducted fieldwork in Jib Godo Natural Forest to investigate the floristic composition and structural analyses of woody plant species in Ethiopia. The vegetation and environmental data were collected from 50 (20 m × 20 m) sample plots established for woody species at every 100 m along seven transect lines and 5 m × 5 m in five subplots for saplings and seedlings using a systematic sampling procedure. In each sample plot, soil samples were obtained from 0–20 cm and mixed to generate a composite sample. A vegetative structural analysis of DBH, height, and stem IVI was computed. There were 65 species of woody plant identified, belonging to 58 genera and 41 families, with 34 species (52.30 percent) being trees, 23 species (35.38 percent) being shrubs, and 8 species (12.30 percent) being lianas. Outside of the sample plot, four other species were identified. Only eleven environmental characteristics were significant at

p

< 0.05, according to the results of canonical correspondence analysis (CCA). In conclusion, the distribution of plant communities and the composition of the species depend on altitude and topographic aspects. The forest’s population structure and regeneration condition suggested that the area had experienced forest degradation and severe anthropogenic disturbances; therefore, the conservation of species and sustainable use of forest genetic resources are advocated as a result of this study’s findings.
Genomic Biomarkers Associated with Response to Induction Chemotherapy in Patients with Localized Pancreatic Ductal Adenocarcinoma
Authors: Ecker Brett L. , Tao Alice J. , Janssen Quisette P. , Walch Henry S. , Court Colin M. , Balachandran Vinod P. , Crane Christopher H. , D'Angelica Michael I. , Drebin Jeffrey A. , Kingham T. Peter , Soares Kevin C. , Iacobuzio-Donahue Christine A. , Vakiani Efsevia , Gonen Mithat , O'Reilly Eileen M. , Varghese Anna M. , Jarnagin William R. , Wei Alice C. 
Published: February 2023

AbstractPurpose:There is increasing use of neoadjuvant chemotherapy in the management of localized pancreatic ductal adenocarcinoma (PDAC), yet there are few validated biomarkers to guide therapy selection. We aimed to determine whether somatic genomic biomarkers predict response to induction FOLFIRINOX or gemcitabine/nab-paclitaxel.Experimental Design:This single-institution cohort study included consecutive patients (N = 322) with localized PDAC (2011–2020) who received at least one cycle of FOLFIRINOX (N = 271) or gemcitabine/nab-paclitaxel (N = 51) as initial treatment. We assessed somatic alterations in four driver genes (KRAS, TP53, CDKN2A, and SMAD4) by targeted next-generation sequencing, and determined associations between these alterations and (1) rate of metastatic progression during induction chemotherapy, (2) surgical resection, and (3) complete/major pathologic response.Results:The alteration rates in driver genes KRAS, TP53, CDKN2A, and SMAD4 were 87.0%, 65.5%, 26.7%, and 19.9%, respectively. For patients receiving first-line FOLFIRINOX, SMAD4 alterations were uniquely associated with metastatic progression (30.0% vs. 14.5%; P = 0.009) and decreased rate of surgical resection (37.1% vs. 66.7%; P &lt; 0.001). For patients receiving induction gemcitabine/nab-paclitaxel, alterations in SMAD4 were not associated with metastatic progression (14.3% vs. 16.2%; P = 0.866) nor decreased rate of surgical resection (33.3% vs. 41.9%; P = 0.605). Major pathologic response was rare (6.3%) and not associated with type of chemotherapy regimen.Conclusions:SMAD4 alterations were associated with more frequent development of metastasis and lower probability of reaching surgical resection during neoadjuvant FOLFIRINOX but not gemcitabine/nab-paclitaxel. Confirmation in a larger, diverse patient cohort will be important before prospective evaluation of SMAD4 as a genomic biomarker to guide treatment selection.