bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation of the occipital transtentorial approach incorporating visualization of the cerebellar tentorium using three-dimensional computed tomography angiography and gadolinium-enhanced T1-weighted magnetic resonance imaging: Technical note
Authors: Shingai Yuto , Kanamori Masayuki , Shimoda Yoshiteru , Kayano Shingo , Nemoto Hitoshi , Mugikura Shunji , Saito Ryuta , Tominaga Teiji 
Published: March 2023

Abstract
The occipital transtentorial approach (OTA) is one of the most useful approaches to the lesions of the pineal region, dorsal brainstem, and supracerebellar region. However, a wide operative field is sometimes difficult to obtain due to the large tentorial sinus and bridging veins. This study evaluated the usefulness of preoperative simulation of OTA, specifically including the cerebellar tentorium in 9 patients. All patients underwent computed tomography angiography and venography and gadolinium-enhanced three-dimensional T1-weighted magnetic resonance images (Gd-3D-T1WI). The images were fused and the cerebellar tentorium and tumor manually extracted from Gd-3D-T1WI to obtain the preoperative simulation images. Visualization of the cerebellar tentorium could discriminate between bridging veins from the occipital lobe and cerebellum, and recognize the site of bridging to the tentorial sinus and variants which may interfere with the tentorial incision. Simulation of the tentorial incision was also possible based on the relationships between the tumor, tentorial sinus, bridging vein, and cerebellar tentorium. The simulation suggested that safe tentorial incision was difficult in two sides because of the crossed tentorial sinus draining the left basal vein and draining veins from the glioblastoma. The OTA was performed in eight cases and no difficulty was experienced in the tentorial incision in all cases. The simulation findings of the bridging vein and tentorial sinus were consistent with the intraoperative findings. Preoperative simulation including the cerebellar tentorium is useful for determining the optimum and safe side and required extent of the tentorial incision necessary for tumor resection with the OTA.
MIA3 promotes the degradation of GSH (glutathione) by binding to CHAC1, thereby promoting the progression of hepatocellular carcinoma
Authors: Zhou Wanbiao , Man Jing , Zuo Shi , Chen Tengxiang , Zhao Xueke , Li Haiyang 
Published: March 2023

Abstract
Background and purpose: MIA3 (melanoma inhibitory active protein 3)/TANGO1 (Golgi transporter component protein) plays an important role in the initiation, development and metabolism of cancer. We aimed to explore the role and underlying molecular mechanisms of MIA3/TANGO1 in the growth and migration of hepatoma cells.
Method: According to the analysis of The Cancer Genome Atlas (TCGA) database, MIA3 is expressed at higher levels in hepatocellular carcinoma (HCC) tissues than in normal tissues. MIA3 gene overexpression and gene knockout was performed via lentiviral transduction. Real-time quantitative polymerase chain reaction (qRT‒PCR), immunohistochemistry, and western blotting were used to detect mRNA and protein expression in HCC tissues and cells. The in vitro function of MIA3in HCC cells was evaluated using Cell Counting Kit-8 (CCK-8), colony formation, cell migration and invasion, and flow cytometry assays. The effect of MIA3expression changes on the growth of transplanted tumours in vivo was evaluated in nude mice. Hep-G2 cells with MIA3overexpression were subjected to RNA-seq, and the downstream target gene CHAC1 (glutathione-specific γ-glutamyl cyclotransferase 1) was selected according to the results of the volcano map of gene enrichment. The relationship between MIA3 and CHAC1 was revealed by coimmunoprecipitation and confocal microscopy.
Result: MIA3 expression was upregulated in HCC organizations and HCC samples in the TCGA dataset. Knocking out MIA3 inhibited the proliferation, migration and invasion of Hep-G2 cells and promoted the apoptosis of Hep-G2 cells. Overexpression of MIA3 in Huh7 cells promoted the proliferation, migration and invasion and suppressed the apoptosis of Huh7 cells. Overexpression of MIA3promoted the growth of HCC in nude mice. Overexpression of MIA3 promoted the expression of CHAC1 and the degradation of glutathione (GSH), thereby promoting the growth and metastasis of HCC cells. Knocking out MIA3 inhibited the expression of CHAC1 and slowed the degradation of GSH, thereby inhibiting the growth and metastasis of HCC cells.
Conclusion: MIA3 further promotes the growth, metastasis and invasion of hepatoma cells by binding to the CHAC1 protein and promoting GSH degradation.
Serum neutralization of SARS-CoV-2 Omicron BA.2, BA.2.75, BA.2.76, BA.5, BF.7, BQ.1.1 and XBB.1.5 in individuals receiving Evusheld
Authors: Zhao Qianqian , Wang Xin , Zhang Ze , Liu Xuefei , Wang Ping , Cao Jin , Liang Qiming , Qu Jieming , Zhou Min 
Published: March 2023

Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is undergoing continuous evolution and convergent mutation, which has led to the rapid emergence of several new variants. These new subvariants carry different mutations in theirreceptor-binding domain (RBD), raising concerns that they may evade neutralizing monoclonal antibodies (mAbs). In this study, we investigated the serum neutralization efficacy of Evusheld (cilgavimab and tixagevimab) antibody cocktails against SARS-CoV-2 Omicron sublineages BA.2, BA.2.75, BA.2.76, BA.5, BF.7, BQ.1.1 and XBB.1.5. Our results show that Evusheld retained neutralizing activity against BA.2, BA.2.75 and BA.5, albeit with somewhat reduced titers. However, the neutralizing activity of Evusheld against BA.2.76, BF.7, BQ.1.1 and XBB.1.5 significantly decreased, with XBB.1.5 showing the greatest escape activity among the subvariants, followed by BQ.1.1, BA.2.76 and BF.7. We also observed that recipients of Evusheld displayed elevated antibody levels in their serum, which efficiently neutralized the original variant, and exhibited different characteristics of infection than those who did not receive Evusheld. These findings provide important guidance for the application of Evusheld in treating SARS-CoV-2 subvariant infections.
Immune niches in brain metastases contain TCF1+ stem-like T cells, are associated with disease control and are modulated by preoperative SRS
Authors: Jansen Caroline S. , Prabhu Roshan S. , Pagadala Meghana S. , Chappa Prasanthi , Goyal Subir , Zhou Chengjing , Neill Stewart G. , Prokhnevska Nataliya , Cardenas Maria , Hoang Kimberley B. , Zhong Jim , Torres Mylin , Logan Suzanna , Olson Jeffrey J. , Nduom Edjah K. , Balzo Luke del , Patel Kirtesh , Burri Stuart H. , Asher Anthony L. , Wilkinson Scott , Lake Ross , Higgins Kristin A. , Patel Pretesh , Dhere Vishal , Sowalsky Adam G. , Khan Mohammad K. , Kissick Haydn , Buchwald Zachary S. 
Published: March 2023

Abstract

The CD8+ T-cell response is prognostic for survival outcomes in several tumor types. However, whether this extends to tumors in the brain, an organ with barriers to T cell entry, remains unclear. Here, we analyzed immune infiltration in 67 brain metastasis (BrM) and found high frequencies of PD1+ TCF1+ stem-like CD8+ T-cells and TCF1- effector-like cells. Importantly, the stem-like cells aggregate with antigen presenting cells in immune niches, and niches were prognostic for local disease control. Standard of care for BrM is resection followed by stereotactic radiosurgery (SRS), so to determine SRS’s impact on the BrM immune response, we examined 76 BrM treated with pre-operative SRS (pSRS). pSRS acutely reduced CD8+ T cells at 3 days. However, CD8+ T cells rebounded by day 6, driven by increased frequency of effector-like cells. This suggests that the immune response in BrM can be regenerated rapidly, likely by the local TCF1+ stem-like population.
Enhanced mechanical and water resistance properties of cassava starch-PVA composites with TiO2 nanofillers for triboelectric nanogenerators films
Authors: Ansori Aris , Soeparman Sudjito , Widhiyanuriyawan Denny , Widodo Teguh Dwi 
Published: March 2023

The utilization of biopolymers for energy applications continues to attract researchers, due to the unique properties of biopolymers that are easily modified, such as cassava starch (CS) biopolymer that has hydroxyl molecular chains. However, the brittle, and non-waterproof nature of starch films is an obstacle to their use in triboelectric nanogenerator (TENG) solid-solid films. This study aims to improve the physicochemical properties of cassava starch films by modifying them into nanocomposite films. The nanocomposite film was made from 70:30 CS/polyvinyl alcohol (PVA) composite and variation of TiO2 nanoparticles addition using solvent casting method. The results showed that the mechanical properties of cassava starch film increased with the addition of PVA. Meanwhile, the addition of TiO2 above 1 wt % of the mechanical properties of the film tends to decrease. The film has low wettability properties with a contact angle of 83.6°. The performance of the nanocomposite film as a Rotary disc freestanding film (RDF-TENG) produces 4.4-fold the output voltage and 2.8-fold the current compared to the film without TiO2. This is a new finding that the CS/PVA-TiO2 nanocomposite film has the potential for TENG films in high-humidity environmental conditions
A new approach to numerical simulation of boundary value problems of the theory of elasticity in stresses and strains
Authors: Khaldjigitov Abduvali , Djumayozov Umidjon , Tilovov Otajon 
Published: March 2023

The main parameters characterizing the process of deformation of solids are displacements, strain and stress tensors. From the point of view of the strength and reliability of the structure and its elements, researchers and engineers are mainly interested in the distribution of stresses in the objects under study. Unfortunately, all boundary value problems are formulated and solved in solid mechanics mainly with respect to displacements, or an additional stress functions. And the required stresses are calculated from known displacements or stress functions. In this case, the accuracy of stress calculation is strongly affected by the error of numerical differentiation, as well as the approximation order of the boundary conditions. The formulation of boundary value problems directly with respect to stresses or strains allows to increase the accuracy of stress calculation by bypassing the process of numerical differentiation.
Therefore, the present work is devoted to the formulation and numerical solution of boundary value problems directly with respect to stresses and strains. Using the well-known Beltrami-Miеchell equation, and considering the equilibrium equation as ah additional boundary condition, a boundary value problem(BVP) is formulated directly with respect to stresses. In a similar way, using the strain compatibility condition, the Beltrami-Mitchell type equations for strains are written.
The finite difference equations for two-dimensional BVP are constructed and written in convenient a form for the use of iterative method. A number of problems on the equilibrium of a rectangular plate under the action of various loads applied on opposite sides are numerically solved. The reliability of the results is ensured by comparing the numerical results of the 2D elasticity problems in stresses and strains, and with the exact solution, as well as with the known solutions of the plate tension problem under parabolic and uniformly distributed loads
Flow distribution analysis of a novel fcc system through experiment study and atomic model
Authors: Siswantara Ahmad Indra , Syafei M. Hilman Gumelar , Budiyanto Muhammad Arif , Widiawaty Candra Damis , Syuriadi Adi , Farhan Tanwir Ahmad , Permana Sulaksana 
Published: March 2023

As the largest palm oil producer in the world, Indonesia has a promising potential to produce green fuel through the Fluid Catalytic Cracking (FCC) process. A novel FCC configuration, FCC Proto X 3, which combines a riser reactor and downer reactor in the system, has been developed. However, several valves including in the FCC system remain a black box to the flow distribution in the system. The objective of this paper is to investigate the effect of the valve setting variation on the airflow distribution of the FCC system. The methodology uses experiment and acausal modeling. The effect of valve setting variation on pressure and average velocity of the airflow has been investigated. The experiment is conducted under cold test conditions, while the acausal model of the FCC system is built by using OpenModelica. It is obtained that valve 2 which controls the flow at the channel toward the regenerator is essential due to its role in controlling the air supply combustion process in the regenerator and driving the spent catalyst particles to the regenerator. Valve 3 is responsible for controlling the flow toward the riser reactor directly. Later, it is responsible for supplying the lifting fluid to support the catalytic cracking reaction at the riser sections. Valve 4 contributes to controlling the lifting fluid to the downer reactor. It will also be responsible for supplying thermal energy from the high-temperature particle catalyst to the reactor. When all valves toward the regenerator and reactor are 100 % open, the measured average velocity at the flue gas outlet and the product outlet are 8.04 m/s and 5.775 m/s respectively. The result shows that the airflow at the FCC system tends to flow through the regenerator. The atomic model estimation also shows a similar trend to the experiment result
Optimization of textile effluent bacterial treatment and improvement of the process efficiency through SPB1 biosurfactant addition
Authors: Mnif Inès , Bouassida Mouna , Ayed Lamya , Ghribi Dhouha 
Published: March 2023

Abstract
The current work aims to optimize biological textile effluent treatment through the use of newly selected bacterial consortia composed of two strains: Citrobacter sedlakii RI11 and Aeromonas veronii GRI. We assessed the effect of SPB1 biosurfactant addition on color removal (CR). The process was optimized by a Box–Bhenken by examining the effect of pH, consortia density and biosurfactant value on treatment efficiency. Firstly, physicochemical analyses of the studied effluent revealed an alkaline pH along with a high content of suspended materials and large amounts of organic matter. Optimal CR and a chemical oxygen demand abatement of about 94 and 86% were obtained when treating the textile effluent at pH 5 with a total optical density of 0.4 and by incorporating 0.01% SPB1 biosurfactant. Additionally, an abolishment of phytotoxicity was registered after treatment optimization. The evaluations of the action mode of both selected bacteria during textile effluent treatment suggested the occurrence of biodegradation phenomena of dyes through enzymatic activities.
Virtual Reflection Group Meetings as a Structured Active Learning Method to Enhance Perceived Competence in Critical Care: Focus Group Interviews With Advanced Practice Nursing Students
Authors: Solberg Marianne Trygg , Sørensen Anne Lene , Clarke Sara , Nes Andrea Aparecida Goncalves 
Published: March 2023

BackgroundAdvanced practice nurses (APNs) are in high demand in critical care units. In Norway, APNs are educated at the master’s degree level and acquire the competence to ensure the independent, safe, and effective treatment of patients in constantly and rapidly changing health situations. APNs’ competence embraces expert knowledge and skills to perform complex decision-making in the clinical context; therefore, it is essential that educational institutions in nursing facilitate learning activities that ensure and improve students’ achievement of the required competence. In clinical practice studies of APN education, face-to-face reflection group (FFRG) meetings, held on campus with the participation of a nurse educator and advanced practice nursing students (APNSs), are a common learning activity to improve the competence of APNSs. Although FFRG meetings stimulate APNSs’ development of required competencies, they may also result in unproductive academic discussions, reduce the time that APNSs spend in clinical practice, and make it impossible for nurse preceptors (NPs) to attend the meetings, which are all challenges that need to be addressed.ObjectiveThis study aimed to address the challenges experienced in FFRG meetings by implementing virtual reflection group (VRG) meetings and to explore the experiences of APNSs, NPs, and nurse educators in VRG meetings as an active learning method supported by technology to stimulate students’ development of the required competence to become APNs in critical care.MethodsThis study adopted a qualitative explorative design with 2 focus group interviews and used inductive content analysis to explore the collected data.ResultsThe main finding is that reflection group meetings supported by technology resulted in a better-structured active learning method. The VRG meeting design allowed APNSs to spend more time in clinical practice placements. The APNSs and NPs experienced that they participated actively and effectively in the meetings, which led to a perceived increase in competence. The APNSs also perceived an improved learning experience compared with their prior expectations.ConclusionsUsers perceived that the implemented novel teaching design supported by technology, the VRG meeting, was a more effective method than FFRG meetings on campus to develop APNSs’ required competence in critical care. The VRG was also perceived as an improved method to solve the challenges encountered in FFRG meetings. Specifically, the APNSs felt that they were prepared to undertake complex decision-making with a higher level of analytic cognition in a clinical context and to lead professional discussions in the ward. This developed teaching design can easily be adapted to diverse educational programs at various levels of professional education.
COVID-19 Vaccine–Related Information on the WeChat Public Platform: Topic Modeling and Content Analysis
Authors: Wu Xiaoqian , Li Ziyu , Xu Lin , Li Pengfei , Liu Ming , Huang Cheng 
Published: March 2023

Background
The COVID-19 vaccine is an effective tool in the fight against the COVID-19 outbreak. As the main channel of information dissemination in the context of the epidemic, social media influences public trust and acceptance of the vaccine. The rational application of health behavior theory is a guarantee of effective public health information dissemination. However, little is known about the application of health behavior theory in web-based COVID-19 vaccine messages, especially from Chinese social media posts.

Objective
This study aimed to understand the main topics and communication characteristics of hot papers related to COVID-19 vaccine on the WeChat platform and assess the health behavior theory application with the aid of health belief model (HBM).

Methods
A systematic search was conducted on the Chinese social media platform WeChat to identify COVID-19 vaccine–related papers. A coding scheme was established based on the HBM, and the sample was managed and coded using NVivo 12 (QSR International) to assess the application of health behavior theory. The main topics of the papers were extracted through the Latent Dirichlet Allocation algorithm. Finally, temporal analysis was used to explore trends in the evolution of themes and health belief structures in the papers.

Results
A total of 757 papers were analyzed. Almost all (671/757, 89%) of the papers did not have an original logo. By topic modeling, 5 topics were identified, which were vaccine development and effectiveness (267/757, 35%), disease infection and protection (197/757, 26%), vaccine safety and adverse reactions (52/757, 7%), vaccine access (136/757, 18%), and vaccination science popularization (105/757, 14%). All papers identified at least one structure in the extended HBM, but only 29 papers included all of the structures. Descriptions of solutions to obstacles (585/757, 77%) and benefit (468/757, 62%) were the most emphasized components in all samples. Relatively few elements of susceptibility (208/757, 27%) and the least were descriptions of severity (135/757, 18%). Heat map visualization revealed the change in health belief structure before and after vaccine entry into the market.

Conclusions
To the best of our knowledge, this is the first study to assess the structural expression of health beliefs in information related to the COVID-19 vaccine on the WeChat public platform based on an HBM. The study also identified topics and communication characteristics before and after the market entry of vaccines. Our findings can inform customized education and communication strategies to promote vaccination not only in this pandemic but also in future pandemics.
O surgimento e o desenvolvimento da epistemologia da administração – inferências sobre a contribuição ao aperfeiçoamento da teoria administrativa.
Authors: Serva Maurício 
Published: March 2023

The Emergence and Development of Administration Epistemology - inferences about the contribution to the advancement of management theory. Este artigo tem origem na constatação do interesse crescente da comunidade científica da administração na construção de uma epistemologia específica nesta área. No Brasil, tal interesse se revela principalmente pela a oferta da disciplina epistemologia em cursos de pós-graduação stricto sensu, pelo estabelecimento da epistemologia enquanto tema em duas divisões acadêmicas da ANPAD, pela realização anual na Universidade Federal de Santa Catarina de um colóquio internacional dedicado ao tema, como também pela discussão frequente de assuntos ligados à epistemologia da administração em eventos e publicações científicas. Todo esse movimento traz consigo uma espécie de questionamento crítico sobre os caminhos da própria ciência que observávamos em outras áreas, mas até então não na administração. Assim sendo, neste artigo adoto como objetivos sintetizar o surgimento e desenvolvimento dessa epistemologia específica, e inferir sobre suas prováveis contribuições para o aperfeiçoamento da teoria da administração. Para tanto, traço um panorama dessa epistemologia, e, em seguida expresso as seguintes inferências sobre algumas das suas possíveis contribuições para o aperfeiçoamento da teoria administrativa: a) amadurecimento da teoria pela adoção de uma atitude reflexiva dos pesquisadores; b) melhoria dos protocolos de pesquisa, adequando os métodos empregados aos objetivos das pesquisas; c) favorecimento da aproximação entre teoria e prática, entre pesquisadores e gestores; d) mapeamento realista do campo de atuação tanto dos pesquisadores como dos gestores; e) uma melhor visão de conjunto do campo da administração.
Цөмийн физикийн аргаар агаарын бохирдлыг биомонитор ашиглан тодорхойлох судалгаа
Authors: Ж Баярмаа , Г Ганболд , Ш Гэрбиш , Б Далхсүрэн , Ц Цэндээхүү 
Published: March 2023

Манай орны үйлдвэр, аж ахуй, соёл, шинжлэх ухаан, боловсрол, төр захиргаа, олон нийтийн байгууллага, газрууд Улаанбаатар, Эрдэнэт, Дархан хотуудад оршихын дээр нийт хүн амын гуравны нэг нь Улаанбаатар хотод төвлөрөөд байна. Хүн амын сууршлыг боловсронгуй болгох, дэд бүтцийг иж бүрэн хөгжүүлэх асуудлыг дагаад, экологийн байнгын хяналт (мониторинг) чухал болоод байна.
Баян хүрээний (таван хар овоо) солирын тогооны геофизикийн тодорхойлолт
Authors: Н Арвисбаатар , Г Батсүх , Ц Баатарчулуун , Б Жавзандулам 
Published: March 2023

Шинжлэх ухааны нэр томъёогоор астроблем гэгдэх солирын бөмбөгдөлтийн тогоо бол байгалийн нэн сонин, сансарын гаралтай бүтцийн нэг билээ. Геологийн эрин галавын урт удаан хугацаанд эх дэлхий маань солирын бөмбөгдөлтөд ихэд нэрвэгдэж байсан нь гарцаагүй бөгөөд тэдгээрийн ул мөр дэлхийн царцдасын хувьсал, элэгдлийн явцаар устан үгүй болж дэлхийн хэмжээнд харьцангуй цөөн тооны /250 орчим/ кратерууд хадгалагдан үлдсэнийг судлан шинэ шинэ мэдээ баримт бүрдүүлсээр байна. Солирын бөмбөгдөлтийн ийм тогооны нэг бол Дорноговь аймгийн нутаг дахь Таван хар овооны орчим орших Баян хүрээ юм.