bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal Glutamatergic and Serotonergic Connectivity in Visual Snow Syndrome and Migraine with Aura
Authors: Puledda Francesca , Dipasquale Ottavia , Gooddy Benjamin J. M. , Karsan Nazia , Bose Ray , Mehta Mitul A. , Williams Steven C. R. , Goadsby Peter J. 
Published: July 2023

ObjectiveNeuropharmacological changes in visual snow syndrome (VSS) are poorly understood. We aimed to use receptor target maps combined with resting functional magnetic resonance imaging (fMRI) data to identify which neurotransmitters might modulate brain circuits involved in VSS.MethodsWe used Receptor‐Enriched Analysis of Functional Connectivity by Targets (REACT) to estimate and compare the molecular‐enriched functional networks related to 5 neurotransmitter systems of patients with VSS (n = 24), healthy controls (HCs; n = 24), and migraine patients ([MIG], n = 25, 15 of whom had migraine with aura [MwA]). For REACT we used receptor density templates for the transporters of noradrenaline, dopamine, and serotonin, GABA‐A and NMDA receptors, as well as 5HT1B and 5HT2A receptors, and estimated the subject‐specific voxel‐wise maps of functional connectivity (FC). We then performed voxel‐wise comparisons of these maps among HCs, MIG, and VSS.ResultsPatients with VSS had reduced FC in glutamatergic networks localized in the anterior cingulate cortex (ACC) compared to HCs and patients with migraine, and reduced FC in serotoninergic networks localized in the insula, temporal pole, and orbitofrontal cortex compared to controls, similar to patients with migraine with aura. Patients with VSS also showed reduced FC in 5HT2A‐enriched networks, largely localized in occipito‐temporo‐parietal association cortices. As revealed by subgroup analyses, these changes were independent of, and analogous to, those found in patients with migraine with aura.InterpretationOur results show that glutamate and serotonin are involved in brain connectivity alterations in areas of the visual, salience, and limbic systems in VSS. Importantly, altered serotonergic connectivity is independent of migraine in VSS, and simultaneously comparable to that of migraine with aura, highlighting a shared biology between the disorders. ANN NEUROL 2023;94:873–884
From‐Neutral‐to‐Neutral Reductive Radical Coupling of Non‐Activated Alcohols and Styrenes
Authors: Suga Takuya , Miki Chinatsu , Ukaji Yutaka 
Published: July 2023

AbstractA reductive radical coupling reaction between non‐activated aliphatic alcohols and styrenes has been discovered through the use of low‐valent Ti‐mediated C−O bond homolysis. A general application of styrene derivatives in radical coupling reactions remains a challenge in organic synthesis. The preliminary investigation revealed that the resulting benzyl radical intermediate behaves differently depending on minor steric differences around the spin center, which results in a lack of generality. The addition of 1,3,5‐trimethyl‐2,5‐cyclohexadiene uniformly hydrogenated the benzyl radicals irrespective of the steric environments of the attacking radicals. Under the optimal reaction conditions, all tertiary, secondary, and primary alcohols were applicable. In this study, alcohols were successfully used directly as radical sources and reacted with a large number of styrenes.
Bionic multifunctional fibrous materials for efficient oil/water separation
Authors: Guo Yuyan , Guo Zhiguang , Liu Weimin 
Published: July 2023

AbstractSpecial wettability fibrous materials have received a lot of attention because of their good connectivity, mechanical flexibility, large specific surface area, and ease of shape manipulation. Their outstanding performance paves the way toward efficient oil/water separation in a variety of environments and for separation requirements. This paper discusses the distinct advantages, challenges, and future research directions of various substrates for fibrous materials, such as nonwoven natural biomass fibers, fabrics, electrospinning fibers, metallic fibers, and inorganic nonmetallic fibers. The special wettability fibrous filter materials and fibrous adsorbents are summarized based on the different separation methods. The principles of preparation of various special wettabilities are introduced, and the unique advantages of fibrous adsorbents are emphasized. The preparation strategy of fibrous filter materials is discussed, as well as some representative work and research progress. The benefits, drawbacks, and research directions in terms of various materials are examined. This article emphasizes the pollution resistance of fibrous filter materials and the elasticity of fibrous adsorbents. Finally, the prospects in terms of the problems, challenges, and future development of special wettability fibrous materials used in oil/water separation are discussed.
Construction Grammar meets Hispanic linguistics
Authors: Hennecke Inga , Wiesinger Evelyn 
Published: July 2023

Abstract
This chapter offers an introduction to the topic and to the individual contributions of the present volume. First, it presents an evaluation of the general potential of combining (usage-based and cognitively oriented) Construction Grammar with Hispanic (and Romance) linguistics. Further, it aims at highlighting the innovative perspective of Construction Grammar(s) in comparison to more traditional approaches for the linguistic phenomena covered in this volume. The chapter concludes with a brief overview of the structure of the book as well as of the individual contributions.
Bard Versus the 2022 American Society of Plastic Surgeons In-Service Examination: Performance on the Examination in Its Intern Year
Authors: Najafali Daniel , Reiche Erik , Araya Sthefano , Camacho Justin M , Liu Farrah C , Johnstone Thomas , Patel Sameer A , Morrison Shane D , Dorafshar Amir H , Fox Paige M 
Published: July 2023

Abstract

Background
Bard is a conversational generative artificial intelligence (AI) platform released by Google (Mountain View, CA) to the public in May 2023.

Objectives
This study investigates the performance of Bard on the American Society of Plastic Surgeons (ASPS) In-Service Examination to compare it to residents' performance nationally. We hypothesized that Bard would perform best on the comprehensive and core surgical principles portions of the examination.

Methods
Google's 2023 Bard was used to answer questions from the 2022 ASPS In-Service Examination. Each question was asked as written with the stem and multiple-choice options. The 2022 ASPS Norm Table was utilized to compare Bard's performance to that of subgroups of plastic surgery residents.

Results
A total of 231 questions were included. Bard answered 143 questions correctly corresponding to an accuracy of 62%. The highest-performing section was the comprehensive portion (73%). When compared with integrated residents nationally, Bard scored in the 74th percentile for post-graduate year (PGY)-1, 34th percentile for PGY-2, 20th percentile for PGY-3, 8th percentile for PGY-4, 1st percentile for PGY-5, and 2nd percentile for PGY-6.

Conclusions
Bard outperformed more than half of the first-year integrated residents (74th percentile). Its best sections were the comprehensive and core surgical principle portions of the examination. Further analysis of the chatbot's incorrect questions might help improve the overall quality of the examination's questions.
Aerosol–cloud interactions at the four candidate sites of the ANAtOLIA project
Authors: Cavazzani S , Bertolin C , Ortolani S , Giordano C , Descloitres J , Fiorentin P , Victori S , Gonzalez Ramos Y , Irbah A , Delanoe J , Berto F , Ziad A 
Published: July 2023

Abstract
ANAtOLIA (Atmospheric monitoring to Assess the availability of Optical Links through the Atmosphere) is a European Space Agency project aimed at selecting sites for optical communication in the atmosphere. The main monitored parameters are cloud cover, aerosol in relation to atmospheric turbulence aimed at monitoring and forecasting the influence of aerosol and cloud cover in reducing optical communication through the atmosphere in selected sites by ESA. In this work, a novel algorithm that uses both the Pearson correlation coefficient and Fourier analysis is used to assess such influences. Aerosol and cloud cover data are obtained from ground stations and satellite over Calern (France), Catania (Italy), Cebreros (Spain), and Lisbon (Portugal). The novel algorithm provides a preliminary long-, medium-, and short-term aerosol–cloud interaction for these four candidate sites, obtaining respectively the variability, the seasonal, and hourly trend of the aerosol concentration; the main medium-term periodicities of aerosols as clouds precursors; the short-term correlation between morning-afternoon aerosol concentration. The use of aerosols as a precursor parameter of cloud cover through a Fourier analysis, makes the algorithm versatile and usable for all sites of optical communication and astronomical importance in which optical transparency is a fundamental requirement, and therefore it is a potential tool to be developed to implement forecasting models.
13Psychoanalysis
Authors: Wynter-Vincent Naomi 
Published: July 2023

Abstract
This chapter reviews four important works of psychoanalytic scholarship published in 2022: Steven Jaron, Christopher Bollas: A Contemporary Introduction; Kate Daniels, Slow Fuse of the Possible: A Memoir of Poetry and Psychoanalysis; Joanna Kellond, Donald Winnicott and the Politics of Care; and Steven Groarke, The Feeling Intellect: An Essay on the Independent Tradition in British and American Psychoanalysis. Following a short introduction, the review is divided into four sections that treat each of the texts in turn: 1. The Unthought Known; 2. The Aesthetic Object; 3. The Politics of Care; 4. The Feeling Intellect.
Preoperative versus intraoperative antiemetic strategies in patients undergoing laparoscopic cholecystectomy
Authors: Theodosopoulou Polyxeni , Staikou Chryssoula , Fassoulaki Argyro 
Published: July 2023

BACKGROUND
Previous studies have determined ondansetron's efficacy in preventing and treating postoperative nausea and vomiting (PONV). However, evidence regarding the timing of drug administration in relation to the surgical procedure remains vague.

OBJECTIVE
To compare the preoperative and intraoperative administration of ondansetron on the incidence of PONV.

DESIGN
Single-centred, randomised, double-blind trial. Patients were recruited between November 2018 and April 2021. Follow-up for PONV and retching was up to 24 h.

SETTING
Aretaieio University Hospital, Greece.

PATIENTS
A total of 121 patients undergoing elective laparoscopic cholecystectomy gave written consent.

INTERVENTIONS
Patients were randomly allocated to the preoperative or the intraoperative group. The preoperative group received 4 mg of ondansetron dissolved in 100 ml of 0.9% saline 1 hour before induction of anaesthesia and 100 ml of 0.9% saline 30 min before end of surgery. The intraoperative group received 100 ml of 0.9% saline 1 h before induction of anaesthesia and 4 mg of ondansetron dissolved in 100 ml of 0.9% saline 30 min before end of surgery.

MAIN OUTCOME MEASURES
The primary outcome was the incidence of nausea and/or vomiting combined at 24 h.

RESULTS
No difference was found between the two groups regarding either the incidence of nausea and vomiting at 24 h (1.7% for the preoperative group versus 5.3% for the intraoperative group, P = 0.31) or the incidence of nausea, vomiting and retching combined (5.3% for the preoperative group versus 10.5% for the intraoperative group, P = 0.30). There was no difference between the groups in the pain intensity at rest or with coughing in the post anaesthesia care unit, at 4, 8 and 24 h postoperatively (P = 0.961, 0.929, 0.748 and 0.883 at rest, and 0.974, 0.220, 0.235 and 0.317 with coughing, respectively).

CONCLUSION
Under the current study design, we found no difference in the incidence of PONV between the administration of ondansetron 1 h before induction of anaesthesia and the intraoperative administration of ondansetron 30 min before the end of surgery.

TRIAL REGISTRATION
ClinicalTrials.gov NCT03023306
Genome-wide analysis of DNA methylation and its relationship with serum homocysteine levels in patients with hypertension
Authors: Zhu Min , An Dewei , Zhang Jin , Tang Xiaofeng , Wang Yan , Zhu Dingliang 
Published: July 2023

Background:
Homocysteine (Hcy) is an independent risk factor for cardiovascular diseases, and elevated plasma Hcy levels could aggravate vascular injury in hypertension. Hyperhomocysteinemia can change the methylation status of global DNA and specific genes. In the present study, we aim to examine the comprehensive influence of Hcy levels on DNA methylation status in patients with hypertension.

Methods:
Epigenome-wide methylation profiles of the peripheral leukocyte DNA of 218 patients with hypertension were analyzed using the Illumina Infinium Methylation EPIC BeadChip. Differentially methylated positions (DMPs) associated with serum Hcy levels were identified by mixed linear regression with the adjustment of potential confounders. Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis were conducted to determine the potential functions of the identified DMPs. The association between the methylation level of DMPs and carotid-femoral pulse wave velocity (Cf-PWV) was also analyzed.

Results:
Five DMPs at cg13169662, cg03179312, cg21976560, cg25262698, and cg09433843 showed significant association with serum Hcy levels (false discovery rate-corrected P < 0.05). An additional six CpG sites met the threshold for suggestive significance (P < 1 × 10−6), among which three DMPs (cg25781123, cg26463106, and cg06679221) were annotated to THUMPD3. Furthermore, the methylation levels of cg13169662 and cg25262698 (RPRD1A) were significantly associated with Cf-PWV.

Conclusion:
Our results suggest that Hcy could induce DNA methylation alteration in patients with hypertension. Further functional research is warranted to elucidate the concrete role of DMPs in hypertension.
A multi-institutional assessment of eye lens dose in nuclear medicine clinics
Authors: Abuqbeitah Mohammad , Demir Mustafa , Işikci Nazenin Ipek , Kozanlilar Burcu , Kovan Bilal , Yeyin Nami , Fikret Çermik Tevik , Şanli Yasemin , Sönmezoğlu Kerim 
Published: July 2023

Aim
The endeavor was to measure the lens dose of actively working staff in nuclear medicine departments.

Material and methods
This study was accomplished in three nuclear medicine sites. A total of 23 workers in nuclear medicine joined this work. Among them are 6 SPECT/ CT technologists, 6 PET/CT technologists, 3 PET/MRI technologists, 5 radiopharmacists, 2 physicists, and 1 physician. EXTDOSE Hp(3) OSL dosimeter with tissue equivalent beryllium-oxide crystal was used for lens dose measurement. All participants were asked to wear the lens dosimeter for 2 months as near to the eye level as possible.

Results
Pooling the dose measures together yielded an average lens dose of 1.48 ± 0.77 mSv for the radiopharmacy team, 1.44 ± 0.26 for PET/ CT technologists, 0.86 ± 0.45 mSv for SPECT/ CT technologists, 0.38 mSv for the sole physician administered 177Lu, and 0.45 ± 0.02 mSv for the physicists conducting 131I therapy. Moreover, normalizing the lens dose to the labeled activity led to a lens dose of 2.2 ± 1.4 µSv/GBq for the radiopharmacy team. Likewise, per administered activity: 23.8 ± 7.3 µSv/GBq for PET/CT and PET/MRI technologists, 12.2 ± 10.5 µSv/GBq 99mTc for SPECT/CT technologists, 6.0 ± 0.81 µSv/GBq 131I for physicists, and 3.0 µSv/GBq 177Lu for the physician.

Conclusion
It was deduced that the annual occupational lens dose of the nuclear medicine workers varied from 2.3 to 11.5 mSv/year; however, one radiopharmacist projected annual lens dose as close to the lens equivalent dose limit (20 mSv/year) as 17.9 mSv.
Automatic Detection of Perilunate and Lunate Dislocations on Wrist Radiographs Using Deep Learning
Authors: Pridgen Brian , von Rabenau Lisa , Luan Anna , Gu Angela J. , Wang David S. , Langlotz Curtis , Chang James , Do Bao 
Published: July 2023

Summary:
Delayed or missed diagnosis of perilunate or lunate dislocations can lead to significant morbidity. Advances in computer vision provide an opportunity to improve diagnostic performance. In this study, a deep learning algorithm was used for detection of perilunate and lunate dislocations on lateral wrist radiographs. A total of 435 lateral wrist radiographs were labeled as normal or pathologic (perilunate or lunate dislocation). The lunate in each radiograph was segmented with a rectangular bounding box. Images were partitioned into training and test sets. Two neural networks, consisting of an object detector followed by an image classifier, were applied in series. First, the object detection module was used to localize the lunate. Next, the image classifier performed a binary classification for normal or pathologic. The accuracy, sensitivity, and specificity of the overall system were evaluated. A receiver operating characteristic curve and the associated area under the curve were used to demonstrate the overall performance of the computer vision algorithm. The lunate object detector was 97.0% accurate at identifying the lunate. Accuracy was 98.7% among the subgroup of normal wrist radiographs and 91.3% among the subgroup of wrist radiographs with perilunate/lunate dislocations. The perilunate/lunate dislocation classifier had a sensitivity (recall) of 93.8%, a specificity of 93.3%, and an accuracy of 93.4%. The area under the curve was 0.986. The authors have developed a proof-of-concept computer vision system for diagnosis of perilunate/lunate dislocations on lateral wrist radiographs. This novel deep learning algorithm has potential to improve clinical sensitivity to ultimately prevent delayed or missed diagnosis of these injuries.
Disparities in Postmastectomy Reconstruction Use among American Indian and Alaska Native Women
Authors: White McKenzie J. , Prathibha Saranya , Praska Corinne , Ankeny Jacob S. , LaRocca Christopher J. , Owen Mary J. , Rao Madhuri , Tuttle Todd M. , Marmor Schelomo , Hui Jane Y. C. 
Published: July 2023

Background:
American Indian/Alaska Native (AI/AN) breast cancer patients undergo postmastectomy reconstruction (PMR) infrequently relative to non-Hispanic White (NHW) patients. Factors associated with low PMR rates among AI/AN women are poorly understood. The authors sought to describe factors associated with this disparity in surgical care.

Methods:
A retrospective cohort study of the National Cancer Database (2004 to 2017) identified AI/AN and NHW women, aged 18 to 64, who underwent mastectomy for stage 0 to III breast cancer. Patient characteristics, annual PMR rates, and factors associated with PMR were described with univariable analysis, the Cochran-Armitage test, and multivariable logistical regression.

Results:
A total of 414,036 NHW and 1980 AI/AN women met inclusion criteria. Relative to NHW women, AI/AN women had more comorbidities (20% versus 12%; Charlson Comorbidity Index ≥ 1; P < 0.001), had nonprivate insurance (49% versus 20%; P < 0.001), and underwent unilateral mastectomy more frequently (69% versus 61%; P < 0.001). PMR rates increased over the study period, from 13% to 47% for AI/AN women and from 29% to 62% for NHW women (P < 0.001). AI/AN race was independently associated with decreased likelihood of PMR (OR, 0.62; 95% CI, 0.56 to 0.69). Among AI/AN women, decreased likelihood of PMR was significantly associated with older age at diagnosis, more remote year of diagnosis, advanced disease (tumor size >5 cm, positive lymph nodes), unilateral mastectomy, nonprivate insurance, and lower educational attainment in patient’s area of residence.

Conclusions:
PMR rates among AI/AN women with stage 0 to III breast cancer have increased, yet they remain significantly lower than rates among NHW women. Further research should elicit AI/AN perspectives on PMR, and guide early breast cancer detection and treatment.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Risk, II.
Impact of moist wound dressing on wound healing time: A meta‐analysis
Authors: Liang Zhengbo , Lai Ping , Zhang Jing , Lai Qing , He Lin 
Published: July 2023

AbstractAmong the assortment of available dressings aimed at promoting wound healing, moist dressings have gained significant popularity because of their ability to create an optimal environment for wound recovery. This meta‐analysis seeks to compare the effects of moist dressing versus gauze dressing on wound healing time. A comprehensive literature search was conducted, encompassing publications up until April 1, 2023, across multiple databases including PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Cochrane Library. Stringent criteria were used to determine study inclusion and evaluate methodological quality. Statistical analyses were performed utilizing Stata 17.0. A total of 13 articles, encompassing 866 participants, were included in the analysis. The findings indicate that moist dressing surpasses gauze dressing in terms of wound healing time (standard mean difference [SMD] −2.50, 95% confidence interval [CI] −3.35 to −1.66, p < 0.01; I2 = 97.24%), wound site infection rate (odds ratio [OR] 0.30, 95% CI 0.17 to 0.54, p < 0.01; I2 = 39.91%), dressing change times (SMD −3.65, 95% CI −5.34 to −1.97, p < 0.01; I2 = 96.48%), and cost (SMD −2.66, 95% CI −4.24 to −1.09, p < 0.01; I2 = 94.90%). Subgroup analyses revealed possible variations in wound healing time based on wound types and regions. This study underscores the significant advantages associated with the use of moist dressings, including expedited wound healing, reduced infection rates, decreased frequency of dressing changes, and lower overall treatment costs.
Improving mental healthcare access and experience for people from minority ethnic groups: an England-wide multisite experience-based codesign (EBCD) study
Authors: Winsper Catherine , Bhattacharya Rahul , Bhui Kamaldeep , Currie Graeme , Edge Dawn , Ellard David R , Franklin Donna , Gill Paramjit S , Gilbert Steve , Miller Robin , Motala Zahra , Pinfold Vanessa , Sandhu Harbinder , Singh Swaran P , Weich Scott , Giacco Domenico 
Published: July 2023

BackgroundLong-standing ethnic inequalities in access and mental healthcare were worsened by the COVID-19 pandemic.ObjectivesStakeholders coproduced local and national implementation plans to improve mental healthcare for people from minority ethnic groups.MethodsExperience-based codesign conducted in four areas covered by National Health Service (NHS) mental health trusts: Coventry and Warwickshire, Greater Manchester, East London and Sheffield. Data were analysed using an interpretivist–constructivist approach, seeking validation from participants on their priority actions and implementation plans. Service users (n=29), carers (n=9) and health professionals (n=33) took part in interviews; focus groups (service users, n=15; carers, n=8; health professionals, n=24); and codesign workshops (service users, n=15; carers, n=5; health professionals, n=21) from July 2021 to July 2022.FindingsEach study site identified 2–3 local priority actions. Three were consistent across areas: (1) reaching out to communities and collaborating with third sector organisations; (2) diversifying the mental healthcare offer to provide culturally appropriate therapeutic approaches and (3) enabling open discussions about ethnicity, culture and racism. National priority actions included: (1) co-ordination of a national hub to bring about system level change and (2) recognition of the centrality of service users and communities in the design and provision of services.ConclusionsStakeholder-led implementation plans highlight that substantial change is needed to increase equity in mental healthcare in England.Clinical implicationsWorking with people with lived experience in leadership roles, and collaborations between NHS and community organisations will be essential. Future research avenues include comparison of the benefits of culturally specific versus generic therapeutic interventions.