bluuebunny/crossref_metadata_2025_split huggingface dataset:
FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer
Authors: Guneri-Sozeri Perihan Yagmur , Özden-Yılmaz Gülden , Kisim Asli , Cakiroglu Ece , Eray Aleyna , Uzuner Hamdiye , Karakülah Gökhan , Pesen-Okvur Devrim , Senturk Serif , Erkek-Ozhan Serap 
Published: February 2023

AbstractBladder cancer is mostly present in the form of urothelium carcinoma, causing over 150,000 deaths each year. Its histopathological classification as muscle invasive (MIBC) and non-muscle invasive (NMIBC) is the most prominent aspect, affecting the prognosis and progression of this disease. In this study, we defined the active regulatory landscape of MIBC and NMIBC cell lines using H3K27ac ChIP-seq and used an integrative approach to combine our findings with existing data. Our analysis revealed FRA1 and FLI1 as two critical transcription factors differentially regulating MIBC regulatory landscape. We show that FRA1 and FLI1 regulate the genes involved in epithelial cell migration and cell junction organization. Knock-down of FRA1 and FLI1 in MIBC revealed the downregulation of several EMT-related genes such as MAP4K4 and FLOT1. Further, ChIP-SICAP performed for FRA1 and FLI1 enabled us to infer chromatin binding partners of these transcription factors and link this information with their target genes. Finally, we show that knock-down of FRA1 and FLI1 result in significant reduction of invasion capacity of MIBC cells towards muscle microenvironment using IC-CHIP assays. Our results collectively highlight the role of these transcription factors in selection and design of targeted options for treatment of MIBC.
Copper-catalyzed alkyne oxidation/Büchner-type ring-expansion to access benzo[6,7]azepino[2,3-b]quinolines and pyridine-based diones
Authors: Jiang Xiao-Lei , Liu Qing , Wei Kua-Fei , Zhang Ting-Ting , Ma Guang , Zhu Xiu-Hong , Ru Guang-Xin , Liu Lijie , Hu Lian-Rui , Shen Wen-Bo 
Published: February 2023

AbstractGeneral access to highly valuable seven-membered rings via Büchner-type reaction remains a formidable challenge. Here we report a Cu-catalyzed intermolecular oxidation of alkynes using N-oxides as oxidants, which enables expedient preparation of valuable benzo[6,7]azepino[2,3-b]quinolines and pyridine-based diones. Importantly, in contrast to the well-established gold-catalyzed intermolecular alkyne oxidation, the dissociated pyridine or quinoline partner could be further utilized to construct N-heterocycles in this system and the reaction most likely proceeds by a Büchner-type ring expansion pathway. A mechanistic rationale for this cascade cyclization is supported by DFT calculations.
Above-ground tree carbon storage in response to nitrogen deposition in the U.S. is heterogeneous and may have weakened
Authors: Clark Christopher M. , Thomas R. Quinn , Horn Kevin J. 
Published: February 2023

AbstractChanges in nitrogen (N) availability affect the ability for forest ecosystems to store carbon (C). Here we extend an analysis of the growth and survival of 94 tree species and 1.2 million trees, to estimate the incremental effects of N deposition on changes in aboveground C (dC/dN) across the contiguous U.S. (CONUS). We find that although the average effect of N deposition on aboveground C is positive for the CONUS (dC/dN = +9 kg C per kg N), there is wide variation among species and regions. Furthermore, in the Northeastern U.S. where we may compare responses from 2000-2016 with those from the 1980s–90s, we find the recent estimate of dC/dN is weaker than from the 1980s–90s due to species-level changes in responses to N deposition. This suggests that the U.S. forest C-sink varies widely across forests and may be weakening overall, possibly necessitating more aggressive climate policies than originally thought.
Steam computing paradigm: Cross‐layer solutions over cloud, fog, and edge computing
Authors: Mchergui Abir , Hajlaoui Rejab , Moulahi Tarek , Alabdulatif Abdulatif , Lorenz Pascal 
Published: February 2023

AbstractConventional infrastructures based on the cloud are not sufficient for the emerging Internet of Things (IoT) applications requirements. Many big problems are shortcomings, especially in terms of network bandwidth and latency. Throughout recent years, the idea to relieve fog computing and edge computing was suggested by bringing data processing capacities closer to these limits to the edge of the network. The authors assume that the full potential of IoT will, in many cases, only be activated by the combination of cloud, fog, and edge computing in a new computing paradigm, given IoT growth and development forecasts. This article discusses the possibility and need for such a paradigm by introducing steam computing as a new distributed type of computing using cloud, fog, and edge utilities to carry out data processing and storage. The authors treat steam computing through four planes: security and privacy plane, data analytics and fault tolerance plane and deployment and test beds plane. Finally, the authors focus on the open issues and future trends in steam computing.
Regards sur le paysage
Authors: Chapuis Élisabeth 
Published: February 2023

L’expérience esthétique du paysage est historiquement construite. Les premières représentations de paysages apparues à la Renaissance ont permis la naissance d’un genre pictural grâce à l’invention de la perspective qui a fourni une technique de représentation de l’espace mais traduirait une volonté d’emprise de l’homme sur la nature dont les manifestations déréglées aboutissent au désastre écologique actuel.
Du côté du promeneur ou du spectateur, peut-on renouer avec un plaisir du paysage prenant en compte d’autres points de vue qui ouvriraient à un espace imaginaire de rêverie et de subjectivité créatrice capable de contrer le pessimisme contemporain ?
Le paysage et les questions qu’il pose à la représentation
Authors: Thibierge Stéphane 
Published: February 2023

Cet article interroge le concept de paysage et en quoi ce concept questionne les éléments de notre représentation. Il montre comment le paysage renvoie d’abord à la reconnaissance d’une forme par un sujet, mais aussi au-delà, et de façon plus complexe, à la dimension du réel et à celle de l’objet telles que la psychanalyse les articule. Le refoulement de ce réel est ce qui produit dans le paysage des éléments non reconnaissables mais plutôt déchiffrables, comme des lettres qui appellent une lecture. En d’autres termes les éléments du paysage et sa structure ne concernent pas seulement l’imaginaire, mais sont aussi de l’ordre du réel et du symbolique. Pour montrer cela, l’article s’appuie sur la théorie et la pratique de l’expérience psychanalytique, et sur ce qu’elle nous permet d’établir.
Il évoque aussi quelques exemples en peinture et en photographie pouvant illustrer les points ici discutés. Enfin il aborde, en relation avec le paysage, les notions respectivement du nu et du visage.
Die Cannabisagentur am Bundesinstitut für Arzneimittel und
Medizinprodukte
Authors: Ledderhose Cindy , Otting Henrike , Wolf Anne , Knöss Werner 
Published: February 2023

ZusammenfassungIm Jahre 2017 legte das sogenannte „Cannabisgesetz“ die Grundlage
für die Errichtung der Cannabisagentur am Bundesinstitut für
Arzneimittel und Medizinprodukte (BfArM). Die Aufgaben der Cannabisagentur
umfassen die Kontrolle und Steuerung des Anbaus und der Herstellung von Cannabis
für medizinische Zwecke in Deutschland. Nach den Regelungen des
Einheitsübereinkommens über Suchtstoffe der Vereinten Nationen
von 1961 nimmt die Cannabisagentur die Cannabisblüten mit der Ernte in
Besitz. Daher ist die Cannabisagentur Inverkehrbringer der
Cannabisblüten als Arzneimittel und agiert als Pharmazeutischer
Unternehmer und Großhändler. Inzwischen sind medizinische
Cannabisblüten, die nach der aktuellen Rechtslage
Betäubungsmittel sind, aus dem Anbau in Deutschland verfügbar
und können von Apotheken bei Vorlage einer individuellen Verschreibung
als Rezepturarzneimittel an Patientinnen und Patienten abgegeben werden.
Für Cannabisblüten als pflanzliches Arzneimittel gelten die
gleichen Ansprüche an eine reproduzierbare pharmazeutische
Qualität wie für andere pflanzliche Arzneimittel.
Pitfalls in Coagulation Testing
Authors: Sachs Ulrich J. 
Published: February 2023

AbstractAssays in the coagulation laboratory are affected by numerous variables. Variables which have impact on the test result can lead to incorrect results, and potentially to consequences for further diagnostic and therapeutic decisions made by the clinician. The interferences can be separated into three main groups: biological interferences, with an actual impairment of the patient's coagulation system (congenital or acquired); physical interferences, which usually occur in the pre-analytical phase; and chemical interferences, because of the presence of drugs (mainly anticoagulants) in the blood to be tested. This article discusses some of these interferences in seven instructive cases of (near) miss events as an approach to generate more attention to these issues.
Evidence-Based Medicine: Principles and Values as Illustrated by the Case of Patient Blood Management
Authors: Van Remoortel Hans , De Buck Emmy , Seifried Erhard , Vandekerckhove Philippe 
Published: February 2023

AbstractEvidence-based medicine is considered 1 of the 15 great inventions in medicine. It aims to remove bias in medical decision-making as much as possible through a rigorous process. In this article, the principles of evidence-based medicine are illustrated using the case of patient blood management (PBM). Acute or chronic bleeding, iron deficiency, and renal and oncological diseases may lead to preoperative anemia. To compensate for severe and life-threatening blood loss during surgery, doctors transfuse red blood cells (RBCs). PBM is an approach to take care of patients at risk for anemia, which includes detecting and treating anemia before surgery. Alternative interventions to treat preoperative anemia are the use of iron supplementation with or without erythro-stimulating agents (ESAs). The best available scientific evidence today indicates that preoperative intravenous (IV) or oral iron monotherapy may not be effective to reduce RBC utilization (low-certainty evidence). Preoperative IV iron supplementation in addition to ESAs is probably effective to reduce RBC utilization (moderate-certainty evidence), whereas oral iron supplementation in addition to ESAs may be effective to reduce RBC utilization (low-certainty evidence). The adverse events of preoperative oral/IV iron and/or ESAs and their impact on patient-important outcomes (morbidity, mortality, quality of life) remain unclear (very low-certainty evidence). Since PBM is a patient-centered approach, emphasis on monitoring and evaluation of patient-important outcomes in future research is urgently needed. Finally, the cost-effectiveness of preoperative oral/IV iron monotherapy is unproven, whereas preoperative oral/IV iron in addition to ESAs is extremely cost-ineffective.
Kneipp-Medizin bei Schlafstörungen
Authors: Schuh Angela 
Published: February 2023

ZusammenfassungHauptursache der nicht organischen Schlafstörung stellt der eigene Lebensstil dar. Deshalb muss die Lebensstiländerung oder -modifikation die erste und wichtigste Maßnahme darstellen, um eine Verbesserung der Schlafsituation zu erreichen. Spezifische Behandlungsansätze bestehen aus kognitiv-verhaltenstherapeutischen Gruppenprogrammen. Aber auch körperliche Aktivität und die Ausübung gemäßigter Sportarten haben ihre schlaffördernde Wirkung belegt. Daneben ist die Kneipp-Therapie ein seit langem anerkanntes Verfahren bei Schlafstörungen. Bei nicht organischen Ein- und Durchschlafstörungen kann jedes Element der Kneipp-Therapie einen eigenständigen Beitrag zur Schlafförderung leisten. Eine begleitende Studie der LMU München („Gesunder Schlaf durch innere Ordnung“) untersuchte bei Menschen mit nicht organischen, lebensstilbedingten Schlafstörungen die kurz- und mittelfristigen Effekte eines 3-wöchigen Kneipp-Kur-Präventionsprogramms im Vergleich zu einer Kontrollgruppe und konnte deutliche und anhaltende Verbesserungen zeigen.
47.1.1.4.12 Synthesis of Alkenes by Palladium-Catalyzed Cross-Coupling Reactions with Carbene Precursors
Authors: Wang K. , Wang J. 
Published: February 2023

AbstractThis review describes the synthesis of multisubstituted alkenes through palladium-catalyzed cross-coupling reactions with carbene precursors. In the past decade, transition-metal-catalyzed cross couplings involving carbenes have witnessed remarkable development, including those that form alkenes as the products. These palladium-catalyzed coupling reactions are summarized here, according to the type of cross-coupling partners and the carbene precursors.
Educational and accessible museums and cultural spaces
Authors: González-Herrera Ana Isabel , Díaz-Herrera Andrea Betsabé , Hernández-Dionis Paula , Pérez-Jorge David 
Published: February 2023

AbstractOffering access to culture and education to all citizens is a challenge nowadays, inclusive and accessible spaces are increasingly necessary if we really want to offer equal opportunities to all people regardless of their condition, physical or health. This systematic review study aims to investigate the situation of accessibility in museums and other cultural spaces as alternative learning spaces. It analyzes the historical evolution of cultural spaces as learning spaces and analyzes the reality of these spaces in terms of their accessibility conditions. For this purpose, an exhaustive search of documents was carried out between 2015 and 2021, following the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) statement, from the Web of Science (WOS), Scopus and Dialnet databases. After the analysis and application of selection criteria, a total of 17 documents were found that show the transformation of these cultural spaces, the improvement of their accessibility and adaptation to the new times. The need to offer cultural spaces for all is a challenge that must be consolidated as a social value.
Tailoring the escape rate of a Brownian particle by combining a vortex flow with a magnetic field
Authors: Abdoli I. , Löwen H. , Sommer J.-U. , Sharma A. 
Published: February 2023

The probability per unit time for a thermally activated Brownian particle to escape over a potential well is, in general, well-described by Kramers’s theory. Kramers showed that the escape time decreases exponentially with increasing barrier height. The dynamics slow down when the particle is charged and subjected to a Lorentz force due to an external magnetic field. This is evident via a rescaling of the diffusion coefficient entering as a prefactor in the Kramers’s escape rate without any impact on the barrier-height-dependent exponent. Here, we show that the barrier height can be effectively changed when the charged particle is subjected to a vortex flow. While the vortex alone does not affect the mean escape time of the particle, when combined with a magnetic field, it effectively pushes the fluctuating particle either radially outside or inside depending on its sign relative to that of the magnetic field. In particular, the effective potential over which the particle escapes can be changed to a flat, a stable, and an unstable potential by tuning the signs and magnitudes of the vortex and the applied magnetic field. Notably, the last case corresponds to enhanced escape dynamics.
Ciprofloxacin properties, impacts, and remediation
Authors: Gauba Pammi , Saxena Arushi 
Published: February 2023

Abstract
The discovery of antibiotics has led to a major development in providing treatment for different types of bacterial infections. Among the numerous types of antimicrobial agents used, fluoroquinolones have shown potential activity against various harmful pathogens, which cause various kinds of infections pertaining to skin, urinary tract, respiratory tract, gastrointestinal tract as well as sexually transmitted diseases (STDs). Among all classes of fluoroquinolones, ciprofloxacin is the most used and shows broad-spectrum activity against both gram-positive and gram-negative bacteria. The pharmacokinetic profile is higher in comparison with other antibiotics. It inhibits DNA replication and transcription. Although the use of ciprofloxacin has helped in decreasing the death rate, its increased usage has caused escalated contamination in soil and water. This has severely affected humans, plants, animals, and microbes. As ciprofloxacin does not immediately biodegrade, therefore, it can easily be found in soil and water sources. The toxicity of ciprofloxacin causes the development of resistance and the generation of reactive oxygen species and oxidative stress among living organisms. It also impacts the reproductive system of fishes and amphibians and plant physiology. In order to remediate the antibiotics from the environment a recent technique, phytoremediation has attracted researchers, which may provide a method for the removal of antibiotics. The present review focuses on the physical and pharmacokinetics properties of ciprofloxacin, its action mechanism, its toxicological effects, effect on microbial community, and various other living organisms along with a discussion of remediation of ciprofloxacin.
Voy a tocarte toa: preferences for sexist music and sexist attitudes predict unwanted sexual attention harassment (Voy a tocarte toa: las preferencias para la música sexista y las actitudes sexistas predicen atención sexual no deseada)
Authors: Saldarriaga Laura , Richter-Sotero Anna , Bohner Gerd 
Published: February 2023

The music genres reggaeton and dembow have attained worldwide popularity. Their song lyrics and music videos often display sexually explicit contents, conveying the sexual objectification and degradation of women. To test possible effects of this content on sexually harassing behaviour, Dominican males were randomly assigned to watch reggaeton music videos ( n = 34), dembow music videos ( n = 31) or no videos ( n = 32). Afterwards, two forms of sexually harassing behaviour towards a (computer-simulated) woman, gender harassment and unwanted sexual attention, were assessed using a computer chat paradigm. Participants’ short-term mating orientation, hostile and benevolent sexist attitudes, acceptance of modern myths about sexual aggression (AMMSA), music preferences and previous exposure to sexist music were also assessed. Results did not show any effects of the music video manipulation on harassing behaviour but revealed correlational links among music preferences, short-term mating orientation, AMMSA, sexist attitudes and displays of unwanted sexual attention. Results are discussed in relation to previous research on the effects of music and attitudinal predictors of sexual harassment conducted in Europe and the USA.
On the gravitational collapse in 4-dimensional Einstein–Gauss–Bonnet gravity
Authors: Hassannejad R , Sadeghi A , Shojai F 
Published: February 2023

Abstract
In this paper, we treat 4-dimensional Einstein–Gauss–Bonnet (EGB) gravity as general relativity with an effective stress-energy tensor. We will study the modified Oppenheimer–Snyder–Datt model of the gravitational collapse of a star in a 4-dimensional EGB black hole (BH). The inside geometry of the star is described by the spatially flat Friedmann–Robertson–Walker metric and the matter is distributed uniformly without any pre-assumption about its equation of state. The exterior EGB BH is smoothly matched to the interior geometry without the requirement of any thin shell. This gives the energy density, pressure, and the equation of state of collapsing matter. At the end, we study the time evolution of event and apparent horizons.
Time domain ptychographic full field optical coherence tomography
Authors: Li Jinxi , Bai Xing , Yang Zhongzhuo , Wang Yujie , Chen Xingyu , Zhou Xin 
Published: February 2023

Abstract
Full field optical coherence tomography (FF-OCT) has the advantage of ultrahigh lateral resolution (∼1 µm) resulting from a relatively high numerical aperture (NA) micro objective. However, usually the field of view of micro objective is limited. Furthermore, in vivo imaging, significant motion artifacts limit the performance of traditional FF-OCT where the quality of the restored image is generally degraded due to the influence of motion artifacts. In this paper, we propose a method of edge-preserving ptychography based on dual-balanced time domain FF-OCT, which we can call it time-domain ptychography full field optical coherence tomography (TD-POCT). The method combines the advantages of both ptychography and dual-balanced FF-OCT, which can overcome the limitation of the field for view of micro objective and suppresses motion blur. Moreover, this method can recover not only the amplitude of each layer, but also the phase information. So in addition to tomography, the system can also be used for surface 3D object reconstruction. Numerical simulation verifies that both the horizontal and vertical resolution can reach a few microns.
A novel recovery strategy from commutation failures considering the frequency constraints of receiving-end system
Authors: Zhang Xiaodi , Gao Qiang , Dan Yangqing , Zhou Yongzhi 
Published: February 2023

Abstract
Commutation failure (CF) threatens system safety with traditional HVDCs. To improve the recovery performance from CF, a novel recovery strategy is proposed, where a dynamic current ramp limiter is introduced to reduce the probability of current overshot during the recovery. The dynamic ramp limiter is designed based on the idea of judging the system recovery state by the dc current level, where a high level corresponds to a high risk of CF. The ramp limit is calculated by the frequency constraint of ac systems. Case studies based on a real-world system are used to verify the effectiveness of the proposed method, and the results show that the proposed method can improve the recovery performance and avoid the continuous CFs.
Research on the capacity allocation of basin hydropower-photovoltaic-storage hybrid power generation system based on flexibility of hydropower and pumped storage power stations
Authors: Lu Ying , Gu Jiaping , Li Liang , Zhou Jia , Zhang Shikai 
Published: February 2023

Abstract
The development and utilization of basin hydropower-photovoltaic-storage integrated energy system aim to smooth out the fluctuation of new energy generation capacity with the regulating ability of hydropower and pumped-storage power station, thus promoting the large-scale consumption of new energy. For regions rich in water, wind, solar, and pumped-storage resources, the main problem is how to allocate a reasonable scale of photovoltaic and wind power projects according to the scale of regional hydropower and pumped-storage power stations and realize the integrated development of multi-energy complementary. In this paper, based on the complementary power output characteristics of cascaded hydropower stations and regional photovoltaic power stations, and the good energy storage regulation of pumped-storage power stations, a capacity optimization model of basin hydropower-photovoltaic-storage hybrid power generation system with the goal of economic optimization under multiple constraints is constructed. It was applied to the planning and construction of the clean energy base in the Tibet-Sichuan section upstream of the Jinsha River, and the combined operation of the hydropower-photovoltaic-storage hybrid power generation system was analyzed to verify its feasibility.
Research on Improved Sag Control-based Microgrid Controller Strategy
Authors: Luo Long , Liu Na 
Published: February 2023

Abstract
Firstly, the basic equivalent model of inverter parallel connection is briefly introduced, and then the basic working principle of sag control is described. The sag control has a certain effect on the regulation of reactive power and active power, but when the line impedance is not equal, the reactive power distribution among the inverters cannot be reasonably dispatched and distributed. The robustness of the system is verified.