bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eating versus sleeping: Lunchtime meals and naps relation to afternoon creativity at work
Authors: Yun Mansik , Beehr Terry 
Published: February 2023

AbstractBased on the Conservation of Resources theory, we develop dual mechanisms by which lunchtime recovery activities predict creativity. Specifically, by conceptualizing the quality of lunchtime naps and meals as examples of recovery activities, we expect these recovery activities help individuals replenish their psychological resources in the form of more work engagement (affective process) and less cognitive depletion (cognitive process). Further, individuals are expected to utilize these available psychological resources to generate creative ideas. To test our model, we used a group‐mean centering approach to focus on within‐person effects by recruiting 230 employees working at construction sites in South Korea. Overall, after removing 242 invalid observations (omitting at least two items and not reporting the duration of a nap), we finalized a total of two‐wave 1598 daily questionnaires. A high quality of lunchtime naps and meals helps individuals recover their emotional resources (more work engagement) and cognitive resources (less cognitive depletion), which predict individuals' creativity. Finally, although indirect effects of the two recovery activities on creativity via affective and cognitive processes were generally supported, the indirect effect of lunch nap quality on creativity via work engagement was not significant, suggesting most of the effect is due to meal quality rather than nap quality.
Keep DRAGging ON: Is solving more problems in DragonBox 12+ associated with higher mathematical performance during the COVID‐19 pandemic?
Authors: Chan Jenny Yun‐Chen , Byrne Chloe , Jerusal Janette , Liu Allison S. , Roberts Justin , Ottmar Erin 
Published: February 2023

AbstractPrior research has shown that game‐based learning tools, such as DragonBox 12+, support algebraic understanding and that students' in‐game progress positively predicts their later performance. Using data from 253 seventh‐graders (12–13 years old) who played DragonBox as a part of technology intervention, we examined (a) the relations between students' progress within DragonBox and their algebraic knowledge and general mathematics achievement, (b) the moderating effects of students' prior performance on these relations and (c) the potential factors associated with students' in‐game progress. Among students with higher prior algebraic knowledge, higher in‐game progress was related to higher algebraic knowledge after the intervention. Higher in‐game progress was also associated with higher end‐of‐year mathematics achievement, and this association was stronger among students with lower prior mathematics achievement. Students' demographic characteristics, prior knowledge and prior achievement did not significantly predict in‐game progress beyond the number of intervention sessions students completed. These findings advance research on how, for whom and in what contexts game‐based interventions, such as DragonBox, support mathematical learning and have implications for practice using game‐based technologies to supplement instruction.
Practitioner notesWhat is already known about this topic
DragonBox 12+ may support students' understanding of algebra but the findings are mixed.
Students who solve more problems within math games tend to show higher performance after gameplay.
Students' engagement with mathematics is often related to their prior math performance.

What this paper adds
For students with higher prior algebraic knowledge, solving more problems in DragonBox 12+ is related to higher algebraic performance after gameplay.
Students who make more in‐game progress also have higher mathematics achievement, especially for students with lower prior achievement.
Students who spend more time playing DragonBox 12+ make more in‐game progress; their demographic, prior knowledge and prior achievement are not related to in‐game progress.

Implications for practice and/or policy
DragonBox 12+ can be beneficial as a supplement to algebra instruction for students with some understanding of algebra.
DragonBox 12+ can engage students with mathematics across achievement levels.
Dedicating time and encouraging students to play DragonBox 12+ may help them make more in‐game progress, and in turn, support math learning.
Microsomal prostaglandin E synthase‐1 inhibition prevents adverse cardiac remodelling after myocardial infarction in mice
Authors: Zhang Yuze , Steinmetz‐Späh Julia , Idborg Helena , Zhu Liyuan , Li Huihui , Rao Haojie , Chen Zengrong , Guo Ziyi , Hu Lejia , Xu Chuansheng , Chen Hong , Korotkova Marina , Jakobsson Per‐Johan , Wang Miao 
Published: February 2023

Background and PurposeHeart failure with reduced ejection fraction (HFrEF) is a major consequence of myocardial infarction (MI). The microsomal prostaglandin E synthase‐1 (mPGES‐1)/PGE2 pathway has been shown to constrain reperfusion injury after acute myocardial ischaemia. However, it is unknown whether pharmacological inhibition of mPGES‐1, a target with lower risk of thrombosis compared with selective inhibition of cyclooxygenase‐2, affects chronic cardiac remodelling after MI.Experimental ApproachMice were subjected to left anterior descending coronary artery ligation, followed by intraperitoneal treatment with the mPGES‐1 inhibitor compound III (CIII) or 118, celecoxib (cyclooxygenase‐2 inhibitor) or vehicle, once daily for 28 days. Urinary prostanoid metabolites were measured by liquid chromatography–tandem mass spectrometry.Key ResultsChronic administration of CIII improved cardiac function in mice after MI compared with vehicle or celecoxib. CIII did not affect thrombogenesis or blood pressure. In addition, CIII reduced infarct area, augmented scar thickness, decreased collagen I/III ratio, decreased the expression of fibrosis‐related genes and increased capillary density in the ischaemic area. Shunting to urinary metabolites of PGI2, not thromboxane B2 or PGD2, after inhibition of mPGES‐1 was positively correlated with cardiac function after MI. CIII administration significantly increased urinary PGI2/PGE2 metabolite ratio compared to vehicle or celecoxib. The PGI2/PGE2 metabolite ratio correlated positively with ejection fraction, fractional shortening and scar thickness. Treatment with 118 also improved cardiac function.Conclusion and ImplicationsInhibition of mPGES‐1 prevented chronic adverse cardiac remodelling via an augmented PGI2/PGE2 metabolite ratio and therefore represents a potential therapeutic strategy for development of HFrEF after MI.
Targeting of SIRPα as a potential therapy for Langerhans cell histiocytosis
Authors: Okamoto Takeshi , Murata Yoji , Hasegawa Daiichiro , Yoshida Makiko , Tanaka Daisuke , Ueda Takashi , Hazama Daisuke , Oduori Okechi S. , Komori Satomi , Takai Tomoko , Saito Yasuyuki , Kotani Takenori , Kosaka Yoshiyuki , Maniwa Yoshimasa , Matozaki Takashi 
Published: February 2023

AbstractLangerhans cell histiocytosis (LCH) is a rare neoplastic disorder characterized by inflammatory lesions arising from the anomalous accumulation of pathogenic CD1a+CD207+ dendritic cells (DCs). SIRPα is a transmembrane protein highly expressed in myeloid cells such as DCs and macrophages. Here we show that SIRPα is a potential therapeutic target for LCH. We found that SIRPα is expressed in CD1a+ cells of human LCH lesions as well as in CD11c+ DCs in the spleen, liver, and lung of a mouse model of LCH (BRAFV600ECD11c mouse), in which an LCH‐associated active form of human BRAF is expressed in a manner dependent on the mouse Cd11c promoter. BRAFV600ECD11c mice manifested markedly increased numbers of CD4+ T cells, regulatory T cells, and macrophages as well as of CD11c+MHCII+ DCs in the spleen. Monotherapy with a mAb to SIRPα greatly reduced the percentage of CD11c+MHCII+ DCs in peripheral blood, LCH‐like lesion size in the liver, and the number of CD11c+MHCII+ DCs in the spleen of the mutant mice. Moreover, this mAb promoted macrophage‐mediated phagocytosis of CD11c+ DCs from BRAFV600ECD11c mice, whereas it had no effects on the viability or CCL19‐dependent migration of such CD11c+ DCs or on their expression of the chemokine genes Ccl5, Ccl20, Cxcl11, and Cxcl12. Our results thus suggest that anti‐SIRPα monotherapy is a promising approach to the treatment of LCH that is dependent in part on the promotion of the macrophage‐mediated killing of LCH cells.
Efficacy and safety of PLDR‐IMRT for the re‐irradiation of recurrent NPC: A prospective, single‐arm, multicenter trial
Authors: Huang Rui , Li Zhihui , Yang Fan , Zhang Yu , Jiang Yanhui , Li Churong , Gao Hui , Li Guanghui , Liu Yimin , Guo Wenyan , Yang Dingqiang , Zhang Shichuan , Li Jie , Wen Hao , Lang Jinyi , Zhang Peng 
Published: February 2023

AbstractSalvage treatment of locoregionally recurrent nasopharyngeal carcinoma (NPC) requires weighing the benefits of re‐irradiation against increased risks of toxicity. Here, we evaluated the outcomes of patients treated with intensity‐modulated‐based pulsed low‐dose‐rate radiotherapy (PLDR‐IMRT) to enhance the curative effect of salvage treatment and reduce RT‐related SAEs. A prospective clinical trial was conducted from March 2018 to March 2020 at multiple institutions. NPC patients who experienced relapse after radical therapy were re‐irradiated with a median dose of 60 Gy (50.4–70 Gy)/30 f (28–35 f) using PLDR‐IMRT. Thirty‐six NPC patients who underwent PLDR‐IMRT for locoregional recurrence were identified. With a median follow‐up of 26.2 months, the objective response rate (ORR) of the entire cohort was 91.6%. The estimated mPFS duration was 28 months (95% CI: 24.9–31.1), and the estimated mLRFS duration was 30.4 months (95% CI: 25.2–35.5). The overall survival (OS) rate for all patients was 80.6%, the progression‐free survival (PFS) rate was 75% and the cancer‐specific survival (CSS) rate was 88.9% at 1 year. The LRFS and DMFS rates were 88.9% and 91.7%, respectively, at 1 year. A combination of systematic therapies could provide survival benefits to patients who experience NPC relapse (p < 0.05), and a Karnofsky performance status (KPS) score of ≥90 was a favorable factor for local control (p < 0.05). The incidence of acute SAEs (grade 3+) from PLDR was 22.2%, and the incidence of chronic SAEs was 19.4% among all patients. PLDR‐IMRT combined with systematic therapy can effectively treat patients with locoregionally recurrent nasopharyngeal carcinoma and causes fewer adverse events than the rates expected with IMRT.
OGG1 aggravates renal ischemia–reperfusion injury by repressing PINK1‐mediated mitophagy
Authors: Zhao Fan , Zhu Jiefu , Zhang Mingjiao , Luo Yanwen , Li Yuzhen , Shi Lang , Huang Jing , Shadekejiang Halinuer , Dong Shengyu , Wu Xiongfei 
Published: February 2023

AbstractRenal ischemia–reperfusion injury (IRI) is mainly responsible for acute kidney injury for which there is no effective therapy. Accumulating evidence has indicated the important role of mitophagy in mitochondrial homeostasis under stress. OGG1 (8‐oxoguanine DNA glycosylase) is known for functions in excision repair of nuclear and mitochondrial DNA. However, the role of OGG1 in renal IRI remains unclear. Herein, we identified OGG1, induced during IRI, as a key factor mediating hypoxia‐reoxygenation‐induced apoptosis in vitro and renal tissue damage in a renal IRI model. We demonstrated that OGG1 expression during IRI negatively regulates mitophagy by suppressing the PINK1/Parkin pathway, thereby aggravating renal ischemic injury. OGG1 knockout and pharmacological inhibition attenuated renal IRI, in part by activating mitophagy. Our results elucidated the damaging role of OGG1 activation in renal IRI, which is associated with the regulatory role of the PINK1/Parkin pathway in mitophagy.
PRAME immunohistochemistry can distinguish melanocytic pseudonests of lichenoid reactions from melanoma in situ
Authors: Roy Simon F. , Panse Gauri , McNiff Jennifer M. 
Published: February 2023

AbstractBackgroundDistinguishing melanocytic pseudonests encountered in lichenoid dermatoses or lichenoid keratoses from melanoma in situ (MIS) with brisk lichenoid inflammation can prove challenging.MethodsWe designed a case–control study to evaluate the accuracy metrics of PRAME immunohistochemistry to distinguish melanocytic pseudonests in lichenoid dermatoses or keratoses from inflamed MIS. Immunostaining for PRAME was performed on paraffin‐embedded formalin‐fixed diagnostic tissue using a rabbit monoclonal antibody to PRAME (Abcam), with a 1:3200 dilution on a Leica Bond detection system.ResultsOur search identified 21 cases of melanocytic pseudonests (n = 21, 46%) encountered in lichenoid dermatoses and 24 cases of inflamed MIS (n = 24, 53%). Each method of evaluating PRAME immunohistochemistry (PRAME+ clusters, PRAME % of melanocytes by four categories and PRAME+ melanocyte counts per linear mm of epidermal basal layer) showed statistically significant differences between the MIS and the pseudonest cohorts (respectively, p < 0.001; p < 0.001; and p < 0.001). Receiver operating characteristics analysis for PRAME+ melanocyte counts per linear mm of epidermal basal layer revealed an area under the curve of 0.9 ± 0.05 (95% confidence interval 0.9–1.0). When determining an optimal cut‐off point for the best Youden index [sensitivity (%) + specificity (%) − 100], the cut‐off of 1.0 PRAME+ melanocytes per linear mm showed a sensitivity of 79.2% and specificity of 85.7% (Youden index 0.65) to distinguish MIS from pseudonests.ConclusionPRAME immunohistochemistry may constitute an additional tool for this challenging differential diagnosis.
Imatinib‐induced lichen planus and lichenoid drug eruption: A report of three cases
Authors: Almheirat Y. , Bouabdalla S. , Daflaoui H. , Zizi N. , Dikhaye S. 
Published: February 2023

AbstractCutaneous adverse effects of imatinib are common and well documented in the literature. However, imatinib‐induced lichen planus is an uncommon side effect with only four reported cases. In addition, reactivation of hepatitis B is an extremely rare association. We report two cases of imatinib‐induced lichen planus, one of which is associated with hepatitis B reactivation, and one case of lichenoid eruption caused by imatinib. The aim of our report is to make physicians aware of this rare association between lichen planus and imatinib. We also recommend screening for hepatitis B virus before starting treatment with imatinib to avoid serious complications.
Exploring patient experience and satisfaction with depot buprenorphine formulations: A mixed‐methods study
Authors: Allen Eve , Samadian Sona , Altobelli Gary , Johnson Jacinta , Holmwood Chris 
Published: February 2023

AbstractIntroductionThe introduction of depot buprenorphine for the treatment of opioid dependence allows for reduced dosing frequency compared with conventional treatments, such as oral methadone and sublingual buprenorphine‐naloxone. Reduced dosing frequency is perceived to reduce issues such as high out‐of‐pocket costs, frequent attendance to pharmacies, stigmatisation and the risk of diversion for unsanctioned opioid use. This study aims to explore the experiences of patients receiving depot buprenorphine from an Australian publicly operated drug and alcohol service.MethodsParticipants were recruited from the service over a 5‐week period in 2021. Twenty‐eight participants consented to be involved in a mixed methods quantitative verbal survey and qualitative interview process.ResultsThe majority of participants reported satisfaction with depot buprenorphine across the domains of efficacy, convenience and global satisfaction. Participants perceived benefits as increased convenience, reduced stigmatisation and the inability to ‘skip’ daily Medication Assisted Treatment for Opioid Dependence (MATOD) doses. There were mixed experiences with the ability for depot buprenorphine to ‘hold’ participants throughout the dosing interval. Reduced contact and disconnection from healthcare services were reported as an issue for some participants when initiating depot buprenorphine.Discussion and ConclusionsPatient perceptions of depot buprenorphine appear to be deeply rooted in prior experience with ‘conventional’ MATOD treatments. Depot buprenorphine is seen to be beneficial socially, personally, and financially by the majority of patients interviewed. The potential for disconnection from services and mixed experiences of efficacy throughout the dosing period may negatively influence patient experience.
Subjective norms as a mediator between exposure to online alcohol and marijuana content and offline use among adolescents
Authors: Cristello Julie V. , Litt Dana M. , Sutherland Matthew T. , Trucco Elisa M. 
Published: February 2023

AbstractIntroductionWhile adolescent substance use (SU) may be viewed as normative, SU can quickly escalate leading to consequences. Social media use may increase SU risk. Despite using social media to connect with others, adolescents also view depictions of glamorised SU by both peers and influential figures. Exposure to online alcohol and marijuana content may impact subjective norms (i.e., injunctive and descriptive) ultimately leading to increased offline SU. Data from a multi‐wave project was collected to assess whether subjective norms‐mediated associations between exposure to alcohol and marijuana content by peers and influential figures on Instagram and Snapchat and offline SU.MethodsAt Wave 1, participants were 264 adolescents (Mage = 14.91, 51% female, 86% White, 85% Hispanic/Latino/a/x).ResultsInjunctive norms significantly mediated associations between exposure to alcohol content posted by peers and influential figures on Instagram and Snapchat and offline alcohol use. Injunctive norms significantly mediated associations between exposure to marijuana content posted by peers and influential figures on Instagram, and peers on Snapchat and offline marijuana use. Descriptive norms significantly mediated associations between exposure to alcohol content posted by peers on Instagram, as well as peers and influential figures on Snapchat and offline alcohol use.Discussion and ConclusionIncreased exposure to online SU content was more consistently associated with injunctive norms rather than descriptive norms. Future research should examine which social media features (e.g., the like button) contribute to increased subjective norms. Overall, findings suggest that social media may strongly convey approval of SU behaviours rather than actual use.
Community pharmacists' roles, attitudes and knowledge regarding provision of screening and brief intervention activities for alcohol use in Catalonia
Authors: Torres‐Novellas Berta , Palacio‐Vieira Jorge , Segura‐García Lidia , Díaz Estela , Rius Pilar , Veciana Antonio , Colom Joan 
Published: February 2023

AbstractIntroductionCommunity pharmacists (CP) are among the health professionals with closest contact to the general population. They play a key role in delivering public health programs. The aim of this study was to analyse the attitudes, knowledge, preparedness and ability to screen and advise on alcohol of CP in Catalonia and their perceptions about the provision of alcohol screening and brief interventions (SBI) in community pharmacies.MethodsThis is an observational, cross‐sectional study. An online survey on attitudes, knowledge and behaviours was sent to all registered CP in Catalonia, and bivariate and multivariate statistical analyses were conducted.ResultsThe response rate was 7.96% (639/8027), more than two‐thirds of respondents were 41 years of age or older and 79.9% were female. Results showed that CP readiness to offer advice on alcohol problems was higher than their preparedness to screen (37.5% vs. 31.8%, respectively). They also showed that having received 1 h or more of training on alcohol and drug‐related health promotion and prevention during the last 5 years increased CP perception of role security and therapeutic commitment related to alcohol.Discussion and ConclusionThis study showed that involving CP in the provision of alcohol SBIs may be feasible in Catalonia. Furthermore, this and previous research show an association between CP training in alcohol or drugs and preparedness to screen and advise on alcohol use. Consequently, promoting alcohol‐related training programs to enhance CP skills is recommended to support successful implementation of alcohol SBI in community pharmacy settings.
Alcohol‐related mortality in four European countries: A multiple‐cause‐of‐death study
Authors: Fihel Agnieszka , Trias‐Llimós Sergi , Muszyńska‐Spielauer Magdalena M. , Majerová Markéta 
Published: February 2023

AbstractIntroductionThe impact of conditions that partly or indirectly contribute to drinking‐related mortality is usually underestimated. We investigate all alcohol‐related multiple (underlying and contributory) causes of death and compare mortality distributions in countries with different levels and patterns of drinking.MethodAnalysis of population‐level mortality data for persons aged 20 and over in Austria, Czechia, Poland and Spain. Age‐standardised death rates and standardised ratios of multiple to underlying cause were calculated for alcohol‐related causes of death.ResultsMultiple‐cause mortality ranged from 20 to 58 deaths per 100,000 for men and from 5 to 16 per 100,000 for women. Liver diseases were the most common underlying and multiple causes, but mental and behavioural disorders were the second or third, depending on country and sex, most prevalent multiple mentions. Two distinct age patterns of alcohol‐related mortality were observed: in Czechia and Poland an inverted‐U distribution with a peak at the age of 60–64, in Austria and Spain a distribution increasing with age and then levelling off for older age groups.Discussion and ConclusionThe importance of alcohol‐related conditions that indirectly impact mortality can be re‐assessed with the use of contributory mentions. The multiple‐cause‐of‐death approach provides convergent results for countries characterised by similar patterns of alcohol consumption. Multiple‐cause mortality was almost double the level of mortality with alcohol as the underlying cause, except in Poland. Mental and behavioural disorders were mostly certified as contributory to other, non‐alcohol‐related underlying causes of death.
Municipal Councillors and the Everyday State: New Representations of Political Accountability in Ahmedabad, India
Authors: Das Rusha , Lutringer Christine 
Published: February 2023

ABSTRACTScholarly literature on municipal councillors in urban India has variously labelled them as ‘lords’, ‘captains’ and ‘shrewd operators’ who have the power to mobilize resources and act as political intermediaries between the state and ordinary citizens. Conversely, voters are seen as collectively trading their votes to secure access to the state's resources. In this article, empirical fieldwork in the city of Ahmedabad, India, suggests that while traditional modes of patron–client relationships continue to exist at the municipal urban governance level, there has been a shift in the roles as perceived by municipal councillors themselves. The ‘state at the roadside’ model of urban governance is being expanded to include new modes and sites of mediation with citizens. Drawing from the literature on political representative claims and social representation theory, this article argues that the changes in the practices of municipal councillors are driven partly by political aspirations that are distinct from their identity as a party karyakarta (worker) and partly as a response to a better‐informed citizenry, referred to as jagrukt janta (public awareness). These shifts create the conditions for new modes of civic engagement and political accountability within existing patronage‐based networks.