bluuebunny/crossref_metadata_2025_split huggingface dataset:
КУЛЬТУРОТВОРЧИЙ ПОТЕНЦІАЛ ВИКОНАВСЬКОЇ ДІЯЛЬНОСТІ ПРОФЕСОРА Є. БОГОСЛОВСЬКОГО
Authors: Badalov Oleg 
Published: April 2023

Мета статті – вивчення виконавської діяльності Є. Богословського як піаніста-соліста, концертмейстера та організатора культурно-просвітницьких заходів у контексті культуротворчих процесів кінця ХІХ – першої третини ХХ століть, зокрема на Чернігівщині. Методологію дослідження складають історико-хронологічний метод – для з’ясування хронотопу виконавської діяльності митця; джерелознавчий та логіко-узагальнюючий – для опрацювання архівних фондів Є. Богословського, вивчення друкованих видань з метою формування джерельної бази дослідження та систематизації отриманих результатів. Наукова новизна статті полягає у введенні до наукового обігу невідомих архівних матеріалів, на підґрунті яких вперше досліджено виконавську діяльність Є. Богословського, як чинник культуротворення та форму взаємодії митця із соціумом. Висновки. Доведено значний культуротворчий потенціал виконавської діяльності Є. Богословського, що спричинила появу та розвиток мистецьких феноменів кінця XIX – першої третини ХХ ст. як на Чернігівщині, так і за її межами. Завдяки співпраці з Керзінським гуртком і «Будинком Пісні», митець брав участь у реалізації двох напрямків музичного просвітництва: змістовному та формотворчому. З’ясовано, що важливим чинником розвитку культурного простору Чернігівщини, де Є. Богословський у 1896–1935 рр. виконував функції безумовного лідера, стало створення ним лекцій-концертів просвітницького спрямування. Участь у цих заходах чернігівських музикантів поряд зі столичними артистами підвищувала мистецький рівень творчих сил регіону, що вплинуло на професіоналізацію музичного руху Чернігівщини (заснування музичних класів, музичного училища) та пожвавило концертну роботу. Значний культуротворчий потенціал, закладений Є. Богословським на Чернігівщині напередодні Другої світової війни, обумовив швидке відродження музичного життя регіону у повоєнні роки, завдяки діяльності його учнів.
ВОКАЛЬНИЙ ЦИКЛ Е. ШОССОНА НА ВІРШІ М. МЕТЕРЛІНКА «ТЕПЛИЦІ»: ВЗАЄМОДІЯ ХУДОЖНІХ СВІТІВ
Authors: Milanina Alyona 
Published: April 2023

Вокальна лірика – це той жанр, якому Ернест Шоссон довіряє свої найбільш інтимні і глибокі переживання. В його творчості музика покликана виражати душевний світ людини і очищати людські душі співчуттям. Слово – носій ідеї, думки, яку наповнює почуттям музика. Музика вступає в тісний союз з поезією, при цьому, якість, як і змістовність поезії, відіграють вирішальну роль у її виборі. Вокально-поетичний цикл «Теплиці» видатних митців Е. Шоссона - М. Метерлінка максимально насичений символікою, що проймає як вербальні, так і музичні ряди, завдяки чому виникає своєрідний живописно-поетично-музичний код, або правила трансформації значень та сенсів у знаки, які ми прочитуємо як меседж авторів (поетів та композитора), що створили подібні тексти. Тому мета наукової статті – розкрити механізми взаємодії музичних, вербальних, візуальних складових у прогресі їх синтезу в композиції «Теплиці». Методи презентованого наукового дослідження: інтермедіальний, семіотичний, компаративний та структурно-функціональний. Наукова новизна – вперше методологія і методика інтермедіального аналізу використовується на матеріалі відомого вокального циклу Е. Шоссона «Теплиці». Висновки. У добре знаному вокальному циклі «Теплиці» Е. Шоссон та М. Метерлінк художньо виразно висвітлена природа людського стану за допомогою символізму в поезії, музиці та кольорі. У репрезентованій науковій роботі представлена кольорова гама твору, з якої стає абсолютно зрозуміло як поступово змінюється настрій головного героя композиції: від одухотвореної надії на краще (№ 1, № 2) через розчарування та відчай (№ 3, № 4) до покори та безмежного сподівання на Бога. У дослідженні наголошується, що для поета й композитора символізм стає тим винятково унікальним «інструментом» мистецтва, який в завуальованій формі максимально точно репрезентує екзистенційні глибини людської душі.
Efficacy of left subclavian artery revascularization strategies during thoracic endovascular aortic repair in patients with type B dissection: A single-center experience of 105 patients
Authors: Wu Xiangyang , Li Yongnan , Zhao Yinglu , Zhu Yilin , Wang Shixiong , Ma Qi , Liu Debin , Gao Bingren , Wei Shilin , Wang Weifan 
Published: April 2023

BackgroundLeft subclavian artery (LSA) revascularization during thoracic endovascular aortic repair (TEVAR) is necessary to reduce postoperative complications in patients with Stanford type B aortic dissection and an insufficient proximal anchoring area. However, the efficacy and safety of different LSA revascularization strategies remain unclear. Here, we compared these strategies to provide a clinical basis for selecting an appropriate LSA revascularization method.MethodsIn this study, we included 105 patients with type B aortic dissection who were treated using TEVAR combined with LSA reconstruction in the Second Hospital of Lanzhou University from March 2013 to 2020. They were divided into four groups according to the method used for LSA reconstruction, namely, carotid subclavian bypass (CSB; n = 41), chimney graft (CG; n = 29), single-branched stent graft (SBSG; n = 21), and physician-made fenestration (PMF; n = 14) groups. Finally, we collected and analyzed the baseline, perioperative, operative, postoperative, and follow-up data of the patients.ResultsThe treatment success rate was 100% in all the groups, and CSB + TEVAR was the most commonly used procedure in emergency settings compared with the other three procedures (P &lt; 0.05). The estimated blood loss, contrast agent volume, fluoroscopic time, operation time, and limb ischemia symptoms during the follow-up were significantly different in the four groups (P &lt; 0.05). Pairwise comparison among groups indicated that the estimated blood loss and operation time in the CSB group were the highest (adjusted P &lt; 0.0083; P &lt; 0.05). The contrast agent volume and fluoroscopy duration were the highest in the SBSG groups, followed by PMF, CG, and CSB groups. The incidence of limb ischemia symptoms was the highest in the PMF group (28.6%) during the follow-up. The incidence of complications (except limb ischemia symptoms) during the perioperative and follow-up periods was similar among the four groups (P &gt; 0.05) The median follow-up time of CSB, CG, SBSG, and PMF groups was significantly different (P &lt; 0.05), and the CSB group had the longest follow-up.ConclusionOur single-center experience suggested that the PMF technique increased the risk of limb ischemia symptoms. The other three strategies effectively and safely restored LSA perfusion in patients with type B aortic dissection and had comparable complications. Overall, different LSA revascularization techniques have their advantages and disadvantages.
Evaluation of early left-sided cardiac reverse remodeling under combined therapy of sacubitril-valsartan and spironolactone compared with angiotensin-converting enzyme inhibitors and spironolactone
Authors: Sacharczuk Wioletta , Dankowski Rafał , Ożegowski Stefan , Rojna Maciej , Szyszka Andrzej 
Published: April 2023

We aimed to compare therapies of sacubitril/valsartan + spironolactone (S/V + S) with angiotensin-converting enzyme inhibitors + spironolactone (ACEI + S) on the left-sided cardiac reverse remodeling (L-CRR). The second objective was to analyze the usefulness of GLS and LVEF in response to therapy.Methods78 patients (mean age 63.4 years, 20 females) with symptomatic heart failure with reduced ejection fraction were randomized to groups of equal numbers, i.e., 39 patients, and started on therapy of S/V + S or ACEI + S. Second evaluations were made after 6–8 weeks of therapy.ResultsGLS changed from −7.4% to −9.4% (18% improvement) in both arms equally. More than 50% of patients, initially with very severe systolic dysfunction (GLS &gt; −8%), were reclassified to severe (GLS −8% to −12%). LVEF did not improve in any of the groups. The quality of life measured by MLHFQ and walking distance by 6-MWT increased. Positive correlations between GLS and 6MWT (r = 0.41, p = 0.02) and GLS and MHFLQ (r = 0.42, p = 0.03) were found. The S/V + S subgroup demonstrated improvements in LVEDV (Δ16.7 vs. 4.5 ml), E/e ratio (Δ 2.8 vs. 1.4), and LAVI (Δ 9.4 vs. 8.4 ml/m2) as compared to ACEI + S.ConclusionGLS, unlike LVEF, detects early changes in LV systolic function after 6–8 weeks of combined therapy, i.e., SV + S and ACE + S. GLS is more useful than LVEF in assessing early response to treatment. The effect of S/V + S and ACEI + S on LV systolic function was comparable, but the improvement in diastolic function as expressed by E/e’, LAVI, and LVEDV was more pronounced with S/V + S.
The incidence and risk factors of perioperative cardiac complications in noncardiac major surgery in high-altitude areas: A prospective trial in Tibet autonomous region, China
Authors: Zhu Qianmei , Duan Hanyu , Liu Zijia , Li Yi , Zhang Yuelun , Labaciren  , Shen Le , Huang Yuguang 
Published: April 2023

BackgroundThe risk of perioperative cardiac complications (PCCs) in patients living in high-altitude areas may increase with more adverse clinical outcomes due to the special geographical environment, which has not yet been studied. We aimed to determine the incidence and analyze risk factors for PCCs in adult patients undergoing major noncardiac surgery in the Tibet Autonomous Region.MethodsThis prospective cohort study enrolled resident patients from high-altitude areas receiving major noncardiac surgery in Tibet Autonomous Region People's Hospital in China. Perioperative clinical data were collected, and the patients were followed up until 30 days after surgery. The primary outcome was PCCs during the operation and within 30 days after the surgery. Logistic regression was used to build the prediction models for PCCs. A receiver operating characteristic (ROC) curve was used to evaluate the discrimination. A prognostic nomogram was constructed to generate a numerical probability of PCCs for patients undergoing noncardiac surgery in high-altitude areas.ResultsAmong the 196 patients living in high-altitude areas involved in this study, 33 (16.8%) suffered PCCs perioperatively and within 30 days after surgery. Eight clinical factors were identified in the prediction model, including older age (P = 0.028), extremely high altitude above 4,000 m (P = 0.442), preoperative metabolic equivalent (MET) &lt; 4 (P = 0.153), history of angina within 6 months (P = 0.037), history of great vascular disease (P = 0.073), increased preoperative high sensitivity C-reactive protein (hs-CRP) (P = 0.072), intraoperative hypoxemia (P = 0.025) and operation time &gt;3 h (P = 0.043). The area under the curve (AUC) was 0.766 (95% confidence interval: 0.785–0.697). The score calculated from the prognostic nomogram predicted the risk of PCCs in high-altitude areas.ConclusionThe incidence of PCCs in resident patients living in high-altitude areas who underwent noncardiac surgery was high, and the risk factors included older age, high altitude above 4,000 m, preoperative MET &lt; 4, history of angina within 6 months, history of great vascular disease, increased preoperative hs-CRP, intraoperative hypoxemia, and operation time &gt;3 h. The prognostic nomogram of this study could help to assess the PCCs for patients in high-attitude areas undergoing noncardiac surgery.Clinical Trial RegistrationClinicalTrials.gov ID: NCT04819698.
Investigating interactive methods in remote chestfeeding support for lactation consulting professionals in Brazil
Authors: de Souza Jessica , Calsinski Cinthia , Chamberlain Kristina , Cibrian Franceli , Wang Edward Jay 
Published: April 2023

ObjectiveLactation consultants (LCs) positively impact chestfeeding rates by providing in-person support to struggling parents. In Brazil, LCs are a scarce resource and in high demand, risking chestfeeding rates across many communities nationwide. The transition to remote consultations during the COVID-19 pandemic made LCs face several challenges to solve chestfeeding problems due to limited technical resources for management, communication, and diagnosis. This study investigates the main technological issues LCs have in remote consultations and what technology features are helpful for chestfeeding problem-solving in remote settings.MethodsThis paper implements qualitative investigation through a contextual study (n=10) and a participatory session (n=5) to determine stakeholders’ preferences for technology features in solving chestfeeding problems.FindingsThe contextual study with LCs in Brazil characterized (1) the current appropriation of technologies that help during consultations, (2) technology limitations that affect LCs’ decision-making, (3) challenges and benefits of remote consultations, and (4) cases that are easy and difficult to solve remotely. The participatory session brings LCs’ perceptions on (1) components for an effective remote evaluation, (2) preferred elements by professionals when providing remote feedback to parents, and (3) feelings about using technology resources for remote consultations.ConclusionFindings suggest that LCs adapted their methodologies for remote consultations, and the perceived benefits of this modality show interest in continuing to provide remote care as long as more integrative and nurturing applications are offered to their clients. We learned that fully remote lactation care might not be the main objective for overall populations in Brazil, but as a hybrid mode of care that benefits parents by having both modalities of consultations available to them. Finally, remote support helps reduce financial, geographic, and cultural barriers in lactation care. However, future research must identify how generalized solutions for remote lactation care can be, especially for different cultures and regions.
Chronic heat stress induces the expression of HSP genes in the retina of chickens (Gallus gallus)
Authors: Bastaki Nasmah K. , Albarjas Taybha A. , Almoosa Fatma A. , Al-Adsani Amani M. 
Published: April 2023

Introduction: Chronic heat stress during summer is a major challenge imposed by global warming. Chickens are more sensitive to heat stress than mammals because they lack sweat glands. Thus, chickens are more susceptible to heat stress during summer than other seasons. Induction of heat shock protein (HSP) genes is one of the primary defense mechanisms against heat stress. Tissue-specific responses exhibited by different classes of HSPs upon exposure to heat stress have been reported previously in different tissues including the heart, kidney, intestine, blood, and muscle, but not in the retina. Therefore, this study aimed to investigate the expression levels of HSP27, HSP40, HSP60, HSP70, and HSP90 in the retina under chronic heat stress.Methods: This study was conducted during the summers of 2020 and 2021 in Kuwait. Chickens (Gallus gallus) were divided into control and heat-treated groups and sacrificed at different developmental stages. Retinas were extracted and analyzed by using Real Time quantitative Polymerase Chain Reaction (RT-qPCR).Results: Our results from the summer of 2021 were similar to that from the summer of 2020, regardless of whether GAPDH or RPL5 was used as a gene normalizer. All five HSP genes were upregulated in the retina of 21-day-old heat-treated chickens and stayed upregulated until 35 days of age, with the exception of HSP40, which was downregulated. The addition of two more developmental stages in the summer of 2021 showed that at 14 days, all HSP genes were upregulated in the retina of heat-treated chickens. In contrast, at 28 days, HSP27 and HSP40 were downregulated, whereas HSP60, HSP70, and HSP90 were upregulated. Furthermore, our results showed that under chronic heat stress, the highest upregulation of HSP genes was seen at the earliest developmental stages.Discussion: To the best of our knowledge, this is the first study to report the expression levels of HSP27, HSP40, HSP60, HSP70, and HSP90 in the retina under chronic heat stress. Some of our results match the previously reported expression levels of some HSPs in other tissues under heat stress. These results suggest that HSP gene expression can be used as a biomarker for chronic heat stress in the retina.
Establishment and validation of exhausted CD8+ T cell feature as a prognostic model of HCC
Authors: Shi Jihang , Li Guangya , Liu Lulu , Yuan Xiandun , Wang Yafei , Gong Ming , Li Chonghui , Ge Xinlan , Lu Shichun 
Published: April 2023

ObjectivesThe exhausted CD8+T (Tex) cells are a unique cell population of activated T cells that emerges in response to persistent viral infection or tumor antigens. Tex cells showed the characteristics of aging cells, including weakened self-renewal ability, effector function inhibition, sustained high expression of inhibitory receptors including PD-1, TIGIT, TIM-3, and LAG-3, and always accompanied by metabolic and epigenetic reprogramming. Tex cells are getting more and more attention in researching immune-related diseases and tumor immunotherapy. However, studies on Tex-related models for tumor prognosis are still lacking. We hope to establish a risk model based on Tex-related genes for HCC prognosis.MethodsTex-related GEO datasets from different pathologic factors (chronic HBV, chronic HCV, and telomere shortening) were analyzed respectively to acquire differentially expressed genes (DEGs) by the ‘limma’ package of R. Genes with at least one intersection were incorporated into Tex-related gene set. GO, KEGG, and GSEA enrichment analyses were produced. Hub genes and the PPI network were established and visualized by the STRING website and Cytoscape software. Transcription factors and targeting small molecules were predicted by the TRUST and CLUE websites. The Tex-related HCC prognostic model was built by Cox regression and verified based on different datasets. Tumor immune dysfunction and exclusion (TIDE) and SubMap algorithms tested immunotherapy sensitivity. Finally, qRT-PCR and Flow Cytometry was used to confirm the bioinformatic results.ResultsHub genes such as AKT1, CDC6, TNF and their upstream transcription factor ILF3, Regulatory factor X-associated protein, STAT3, JUN, and RELA/NFKB1 were identified as potential motivators for Tex. Tex-related genes SLC16A11, CACYBP, HSF2, and ATG10 built the HCC prognostic model and helped with Immunotherapy sensitivity prediction.ConclusionOur study demonstrated that Tex-related genes might provide accurate prediction for HCC patients in clinical decision-making, prognostic assessment, and immunotherapy. In addition, targeting the hub genes or transcription factors may help to reverse T cell function and enhance the effect of tumor immunotherapy.
Feasibility of submerged floating tunnel with polygonal cross-sections — investigation from a viewpoint of submarine slide hazards
Authors: Fan Ning , Hu Yixuan , Wu Hao , Li Xiaobing , Jiang Jianxiong , Xie Jiacheng 
Published: April 2023

Recently, submerged floating tunnels have generated a lot of interest due to their unique cross-water traffic benefits. However, the destructive threat of submarine slide hazards was not fully considered in the design scheme of submerged floating tunnels, in particular to the feasibility of applying various cross-section forms on land to submerged floating tunnels under that hazard influence. This study mainly investigates the load effect of submerged floating tunnels with polygonal cross-sections (comprising three types: square, hexagon, and octagon) under the impact of submarine slides, via a computational fluid dynamics (CFD) approach. Results show that the impact forces produced by submarine slides on submerged floating tunnels are significant (e.g., submarine slides with a velocity of 4 m/s may produce a force level near 1×105 N/m), where the horizontal impact force components should be given priority consideration based on the general working environment of submerged floating tunnels. Compared with typical circle tunnels, polygonal tunnels suffer higher impact forces, and the polygonal types with fewer edges show a greater impact force. Finally, a simplified force evaluation approach for the submerged floating tunnel with polygonal cross-sections is proposed for guiding the relevant engineering design.
Docetaxel-induced cognitive impairment in rats can be ameliorated by edaravone dexborneol: Evidence from the indicators of biological behavior and anisotropic fraction
Authors: Liu Ping , Liu Hai , Wei Lijun , Shi Xun , Wang Wei , Yan Shengxiang , Zhou Wenya , Zhang Jiangong , Han Suxia 
Published: April 2023

ObjectiveThis study aimed to investigate the effect of Edaravone Dexborneol (ED) on impaired learning and memory in docetaxel (DTX)-treated rats using cognitive behavior assessments and magnetic resonance diffusion tensor imaging (DTI).Materials and methodsIn total, 24 male Sprague–Dawley rats were divided into control, low-dose DTX (L-DTX) model, and high-dose DTX(H-DTX) model groups, with eight rats in each group, numbered 1–8. The rats were intraperitoneally injected with 1.5 mL of either normal saline (control group), or 3 mg/kg and 6 mg/kg DTX (L-DTX and H-DTX groups, respectively), once a week for 4 weeks. The learning and memory abilities of each group were tested using a water maze. At the end of the water maze test, rats 1–4 in each group were treated with ED (3 mg/kg, 1 mL), and rats 5–8 were injected with an equal volume of normal saline once a day for 2 weeks. The learning and memory abilities of each group were evaluated again using the water maze test, and the image differences in the hippocampus of each group were analyzed using DTI.Results(1) H-DTX group (32.33 ± 7.83) had the longest escape latency, followed by the L-DTX group (27.49 ± 7.32), and the Control group (24.52 ± 8.11) having the shortest, with the difference being statistically significant (p &lt; 0.05). (2) Following ED treatment, compared to rats treated with normal saline, the escape latency of the L-DTX (12.00 ± 2.79 vs. 10.77 ± 3.97, p &lt; 0.05), and the H-DTX (12.52 ± 3.69 vs. 9.11 ± 2.88, p &lt; 0.05) rats were significantly shortened. The residence time in the target quadrant of H-DTX rats was significantly prolonged (40.49 ± 5.82 vs. 55.25 ± 6.78, p &lt; 0.05). The CNS damage in the L-DTX rats was repaired to a certain extent during the interval between the two water maze tests (28.89 ± 7.92 vs. 12.00 ± 2.79, p &lt; 0.05). (3) The fractional anisotropy (FA) value of DTI in the hippocampus of rats in the different groups showed variable trends. After treatment with ED, though the FA values of most areas in the hippocampus of rats in L-DTX and H-DTX groups were higher than before, they did not reach the normal level.ConclusionED can ameliorate the cognitive dysfunctions caused by DTX in rats by improving the learning and memory impairment, which is reflected in the recovery of biological behavior and DTI indicators of the hippocampus.