bluuebunny/crossref_metadata_2025_split huggingface dataset:
A hybrid multi‐criteria decision‐making approach to evaluate interrelationships and impacts of supply chain performance factors on pharmaceutical industry
Authors: Khan Sharfuddin Ahmed , Gupta Himanshu , Gunasekaran Angappa , Mubarik Muhammad Shujaat , Lawal Jennifer 
Published: December 2022

AbstractPharmaceutical Supply Chain (PSC) plays a critical role in the healthcare sector. This study identifies, validates, and prioritises the factors that play a crucial role in PSC performance, adopting a threefold approach. In the first stage performance, indicators were identified through an extensive review of the literature. With the help of expert opinion, the identified factors were validated and then categorised based on technological—organisational—environmental (TOE) and supply chain (SC) theories to propose a framework. The Pakistani Pharmaceutical sector firms were selected to investigate the cause and effect relationship among the factors, their interdependencies, and impact on overall PSC performance. This investigation was supported by a novel integrated analytic model composed of best worst method (BWM), decision‐making trial and evaluation laboratory (DEMATEL), and analytical network process (ANP) methods. The results indicate that ‘human resource skills, competencies, and involvement’, ‘process improvement and healthcare reform, and manufacturing’, and ‘distribution and inventory management’ are the top three factors that have a high impact on the overall PSC performance. This study outcome help inform decision‐makers and managers in the healthcare sector in formulating strategies to improve their SC performance.
Detection and alterations of acetylcarnitine (AC) in human liver by 1H MRS at 3T after supplementation with l‐carnitine
Authors: Savic Dragana , Mózes Ferenc E. , Green Peregrine G. , Burrage Matthew K. , Kjær Mette Skalshøi , Hodson Leanne , Neubauer Stefan , Pavlides Michael , Valkovič Ladislav 
Published: December 2022

PurposeAcetylcarnitine can be assessed in vivo using proton MRS (1H‐MRS) with long TEs and this has been previously applied successfully in muscle. The aim of this study was to evaluate a 1H‐MRS technique for liver acetylcarnitine quantification in healthy humans before and after l‐carnitine supplementation.MethodBaseline acetylcarnitine levels were quantified using a STEAM sequence with prolonged TE in 15 healthy adults. Using STEAM with four different TEs was evaluated in phantoms. To assess reproducibility of the measurements, five of the participants had repeated 1H‐MRS without receiving l‐carnitine supplementation. To determine if liver acetylcarnitine could be changed after l‐carnitine supplementation, acetylcarnitine was quantified 2 h after intravenous l‐carnitine supplementation (50 mg/kg body weight) in the other 10 participants. Hepatic lipids were also quantified from the 1H‐MRS spectra.ResultsThere was good separation between the acetylcarnitine and fat in the phantoms using TE = 100 ms. Hepatic acetylcarnitine levels were reproducible (coefficient of reproducibility = 0.049%) and there was a significant (p < 0.001) increase in the relative abundance after a single supplementation of l‐carnitine. Hepatic allylic, methyl, and methylene peaks were not altered by l‐carnitine supplementation in healthy volunteers.ConclusionOur results demonstrate that our 1H‐MRS technique could be used to measure acetylcarnitine in the liver and detect changes following intravenous supplementation in healthy adults despite the presence of lipids. Our techniques should be explored further in the study of fatty liver disease, where acetylcarnitine is suggested to be altered due to hepatic inflexibilities.
Correlation between health literacy and health‐related quality of life in patients with diabetic peripheral neuropathy: The mediating role of self‐management
Authors: Gao Yuqi , Yan Keshu , Yan Xiangru , Xi Na , Gao Jia , Ren Hengjie 
Published: December 2022

AbstractAimThe aims of the study were to analyse the current situation of health literacy (HL), self‐management and health‐related quality of life (HRQOL) in patients with diabetic peripheral neuropathy (DPN), to explore the correlation between the three and to verify the mediating role of self‐management in HL and HRQOL.DesignA cross‐sectional survey.MethodsThe convenience sampling method was used to select 401 DPN patients attending the First Hospital of Jinzhou Medical University in Liaoning Province, China, from December 2020 to December 2021 as the study population. The research instrument included socio‐demographic characteristics questionnaire, Health Literacy Management Scale (HeLMS), Summary of Diabetes Self‐Care Activities (SDSCA) and Short‐Form 12‐item Health Survey (SF‐12). SPSS 25.0 was applied to the data for descriptive analysis, Pearson correlation analysis and stratified multiple regression analysis. Mediating effects were tested using SPSS PROCESS macro 4.0 software.ResultsHL and self‐management of DPN patients correlated positively with HRQOL. The mediation role of self‐management was significant in the relationship between HL and physical and mental HRQOL (physical component summary: β = 0.26, P < 0.01; mental component summary: β = 0.18, P < 0.01), with mediating effects accounting for 35.62% and 34.62% of the total effect.ConclusionsThere was a positive correlation between HL, self‐management and HRQOL in patients with DPN. Self‐management plays a partially mediating role in the relationship between HL and HRQOL in DPN patients. It means that HRQOL in this population can be improved by increasing HL and thus self‐management in DPN patients.Patient or Public ContributionNone.
Recurrence risk assessment for stage III colorectal cancer based on five methylation biomarkers in plasma cell‐free DNA
Authors: Wang Wei , Zhu Xiaohui , Zhang Xuecong , Lei Chengyong , Zeng Zhicheng , Lan Xiaoliang , Cui Wenzhi , Wang Feifei , Xu Shaowan , Zhou Juan , Wu Xuehui , Deng Haijun , Li Xia , Fan Jianbing , Ding Yanqing , Huang Zhongxi , Liang Li 
Published: December 2022

AbstractFor stage III colorectal cancer (CRC) patients with a high risk of recurrence, intensified adjuvant chemotherapy can improve overall survival. We aimed to develop a circulating tumor DNA (ctDNA) methylation marker model for predicting the relapse risk of stage III CRC patients. Differentially methylated markers identified between 53 normal mucosa samples and 165 CRC tissue samples, as well as between plasma samples from 75 stage I/II (early‐stage) CRC patients and 55 stage IV (late‐stage) CRC patients, were analyzed using Student's t‐tests. The overlapping methylation markers shared by plasma and tissue samples were used to establish a methylation marker model to evaluate the tumor burden in the peripheral blood of CRC patients using the random forest method. This model was verified in the validation cohort (n = 44) and then applied to predict recurrence risk in 50 stage III CRC patients and monitor the clinical disease course in serial samples from four CRC patients. We built a five‐marker‐based ctDNA methylation model that had high sensitivity (84.21%) and specificity (84%) in identifying late‐stage CRC in a validation cohort containing 24 stage I/II CRC patients and 20 stage IV CRC patients. The model achieved high sensitivity (87.5%) and specificity (94.12%) in predicting tumor relapse in an independent cohort of 50 stage III CRC patients and could be an independent recurrence risk factor for stage III patients [Hazard ratio (HR), 60.4; 95% confidence interval (CI): 7.68–397; p = 9.73e−5]. Analysis of serial blood samples of CRC showed that the model could monitor disease relapse earlier than imaging examination and serum carcinoembryonic antigen (CEA) and so may provide an opportunity for the early adjustment of therapeutic strategies. Moreover, the model could potentially monitor the clinical course and treatment response dynamically. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
v‐SYMPHONY career development series: A collaboration to enhance professional awareness for pediatric hematology oncology trainees
Authors: Tal Adit L. , Bailey Kayleen A. , Chou Alexander , Offer Katharine , Rosenblum Jeremy , Moerdler Scott , Askew Megan , Roberts Stephen , Vagrecha Anshul , Orsey Andrea , Robbins Gabriel , Satwani Prakash , Pierro Joanna , Levine Jennifer 
Published: December 2022

AbstractBackgroundA recent survey of pediatric hematology oncology (PHO) physicians identified that a majority believe fellows are struggling to find jobs that align with their goals. Career development for trainees has historically been home institution‐specific, limiting fellows’ exposures to career path possibilities. The “virtual‐Symposium of Pediatric Hematology/Oncology of New York (v‐SYMPHONY)” instituted a tristate Career Development Series for PHO trainees to better address their needs and increase awareness of the variety of PHO career opportunities.ProcedureThe v‐SYMPHONY Career Development Series incorporated three sessions: (a) institutional perspective, (b) individual perspectives, and (c) nuts and bolts of job search. Pre‐ and post‐series surveys were administered to participants to measure impact.ResultsForty‐one fellows registered for the series and completed a pre‐survey. Over half (54%) were in their third or later year of fellowship. Careers with a clinical focus were the most commonly desired career path (59%). Most had received career development advice only from faculty within their institutions (90%). Post‐surveys were completed by 11 PHO fellows. Overall, 100% of respondents reported benefiting from the career sessions and recommended the series should be repeated annually. Over 90% learned new information to prepare for the job search.ConclusionsThe v‐SYMPHONY Career Development Series for PHO fellows across multiple institutions was established and was extremely well received by its participants. PHO fellows agreed that these sessions were beneficial in helping prepare them for the job search process. An annual regional Career Development Series is feasible and is strongly suggested to support PHO fellows.
Multi‐institution analysis of tumor mutational burden and outcomes in pediatric central nervous system tumor patients
Authors: Parisi Rose , Patel Roshal R. , Rood Gavrielle , Bowden Acacia , Turco George , Korones David N. , Andolina Jeffrey R. , Comito Melanie , Barth Matthew , Weintraub Lauren 
Published: December 2022

AbstractBackgroundPediatric central nervous system (CNS) tumors are the leading cause of pediatric cancer mortality. Research addressing genomic biomarkers and clinical outcomes is needed to inform therapeutic decision‐making.MethodsWe conducted a retrospective analysis of pediatric patients (age <21) diagnosed with a primary CNS tumor at four upstate New York hospitals from 2008 to 2021. Clinical and histopathologic data were identified from each patient, including genomic analysis of somatic mutations and tumor mutational burden (TMB) where available. These variables were each compared with overall survival using Cox regression analyses. Multivariable analysis was conducted to identify patient characteristics that may independently predict survival.ResultsWe identified 119 patients. Common tumor types included low‐grade glioma (N = 51), high‐grade glioma (N = 29), and medulloblastoma (N = 11). Common driver mutations included TP53 inactivation (N = 16), BRAF–KIAA1549 fusion (N = 16), FGFR1 amplification (N = 12), BRAF V600E mutation (N = 12), NF1 loss (N = 12), and H3F3A K28M mutation (N = 6). Median TMB was one mutation/megabase (mut/Mb, range = 0–132). Overall survival was 79.9%. Variables associated with poorer survival on univariable analysis were higher TMB (p = .002, HR 4.97), high‐grade tumors (p = .009, HR 84.3), and high‐grade glioma histology (p = .021, HR 3.14). Multivariable analyses further identified TMB (p = .011, HR 4.46) and high‐grade histology (p = .015, HR 5.28) as independently predictive of worse survival. Tumor progression was more common in high‐TMB (N = 15, 44%) than in low‐TMB tumors (N = 19, 35%).ConclusionsHigh TMB is correlated with higher rates of progression and death as compared to low‐TMB tumors. These findings may help identify patients who may benefit from alternative treatments, such as immunotherapies.
Vibration behavior of a carbon fiber‐reinforced polymer composite sandwich panel: Rhombus core versus elliptical core
Authors: Eratbeni Mehdi Gholizadeh , Rostamiyan Yasser 
Published: December 2022

AbstractExploring lightweight sandwich structures with excellent load‐bearing and vibration damping performances is one of the important topics in structural and functional applications. The aim of the present research is to design, fabricate carbon fiber‐reinforced polymer (CFRP) sandwich panels with rhombus cores and investigate their modal characteristics by comparing with the traditional elliptical sandwich structure experimentally and numerically. In order to obtain modal properties including natural frequencies, damping ratio, mode shapes, and frequency responses of the fabricated structure, modal experiment is performed using a modal hammer with an acceleration sensor. Furthermore, a finite element method is developed to validate the precision of the experimental data. It is recognized that the finite element results are in remarkably great agreement with those obtained by modal experiment. The experimental results showed that the natural frequencies of the sandwich structures with rhombus are much higher than that of the elliptical sandwich structures under free–free boundary conditions and equal relative density of the truss cores.
Trends in dispensed prescriptions for opioids, sedatives, benzodiazepines, gabapentin, and stimulants to children by general dentists, 2012–2019
Authors: Callaway Kim Katherine , Khouja Tumader , Burgette Jacqueline M. , Evans Charlesnika T. , Calip Gregory S. , Gellad Walid F. , Suda Katie J. 
Published: December 2022

AbstractPurposeOpioids, benzodiazepines and sedatives can manage dental pain, fear and anxiety but have a narrow margin of safety in children. General dentists may inappropriately prescribe gabapentin and stimulants. National evidence on dispensing rates of these high‐alert medicines by dentists to children is limited.MethodsWe utilize join‐point regression to identify changes in fills for opioids, sedatives, benzodiazepines, gabapentin, and stimulants to children <18 years from 2012 to 2019 in a national dataset comprising 92% of dispensed outpatient prescriptions by dentists.ResultsFrom 2012 to 2019, 3.8 million children filled prescriptions for high‐alert drugs from general dentists. National quarterly dispensing of high‐alert drugs decreased 63.1%, from 10456.0 to 3858.8 days per million. Opioids accounted for 69.4% of high‐alert prescriptions. From 2012 to 2019, fills for opioids, sedatives, benzodiazepines, and stimulants decreased by 65.2% (7651.8 to 2662.7), 43.4% (810.9 to 458.7), 43.6% (785.7 to 442.7) and 89.3% (825.6 to 88.6 days per million), respectively. Gabapentin increased 8.1% (121.8 to 131.7 days per million). A significant decrease in high‐alert fills occurred in 2016, (−6.0% per quarter vs. ‐1.6% pre‐2016, P‐value<0.001), especially for opioids (−7.0% vs. ‐1.2%, P‐value<0.001). Older teenagers (15–17 years) received 42.5% of high‐alert prescriptions. Low‐income counties in the South were overrepresented among top‐prescribing areas in 2019.ConclusionsWe found promising national decreases in fills for high‐alert medicines to children by general dentists from 2012 to 2019. However, older teenagers and children in some counties continued to receive dental opioids at high rates. Future efforts should address non‐evidence‐based pain management in these groups.
Preparation of form‐stable silica/polyethylene glycol composites using flash‐drying for large‐scale melt‐spun fibers with thermal management property
Authors: Chen Ziye , Zhou Jialiang , Jiang Yi , Hu Zexu , Yin Siyu , Wang Qianqian , Innocent Mugaanire Tendo , Xiang Hengxue , Zhu Meifang 
Published: December 2022

AbstractThe combination of phase change materials (PCMs) with fibers can afford smart fibers with thermal management properties. However, the issues of easy leakage and poor thermal stability of PCMs often limit their use in high‐temperature spinning. Herein, we report a form‐stable PCM of spherical SiO2/PEG composite that was prepared through flash‐drying using inorganic dendritic silica (D‐SiO2) as the core skeleton to support organic polyethylene glycol (PEG). The SiO2/PEG composite not only presents high crystallization enthalpy (101.35 J/g), but also maintains a superior phase change stability. Meanwhile, it exhibits a significant temperature hysteresis effect during heating and cooling, and the endothermic and exothermic time are 381.95 and 293.57 s, respectively. Because the degradation temperature of 300°C for SiO2/PEG is higher than the melt processing temperature of 240–270°C for the preparation of polyamide 6 (PA6) fibers, PA6/SiO2/PEG fibers were prepared using melt spinning. The prepared PA6/SiO2/PEG fibers exhibit high latent heat (17.14 J/g), outstanding thermal cycling stability and satisfactory temperature adjustment properties, and the temperature‐adjustment time of 458.97 s and temperature difference of 10.68°C under the thermal environment. Moreover, the tensile strength of PCFs‐20% reached 1.97 cN/dtex after drawing, which make PCFs meet the requirements of uses in textile industries.
Improving the consistency of environmental stress cracking resistance testing for polyethylenes
Authors: Gritsichine Vladimir , Marway Heera S. , Vlachopoulos John , Thompson Michael R. 
Published: December 2022

AbstractThis paper explores a novel modification to the Bell Test (ASTM‐D1693) for minimizing its variability in failure time by the introduction of heat notching. The new notching technique for assessing environmental stress cracking resistance was evaluated with four different grades of polyethylene and compared to results using the ASTM standard for notching. Differences in both the failure time and the associated variability were witnessed with this technique, evaluated at various annealing conditions between the cold crystallization temperature and crystal melting temperature of a polyethylene. Best results were found using the midpoint temperature between these two conditions for the heated blade. Localized elastic moduli for the notched samples were obtained by force mapping via atomic force microscopy, showing decreased crystallinity content at the point of concentrated stress was favored for more consistent failure times. The work highlights the critical nature of local phase morphology at the notch in the assessment of environmental stress cracking resistance.
Modified NPOH Equation Showing Terminal Effect: Boiling point of homologs monosubstituted alkanes (RX)
Authors: Cao Chao‐Tun , Zhang Lanyu , Cao Chenzhong 
Published: December 2022

AbstractEffect of terminal group on the changes in physicochemical properties (P(n)) of homologs monosubstituted alkanes (RX) is still unclear topic. In this work, take the boiling points (Tb) of 15 homologs RX as examples; the effects of terminal X on the Tb were investigated, in which the X involves F, Cl, Br, I, OH, CN, NH2, CO2H, CHO, SH, C6H5, CH=CH2, C≡CH, c‐C5H9, and c‐C6H11. A general equation expressing the Tb of the homologs RX was proposed, named the NPOH Equation Showing Terminal Effect, as follows: ln (Tb (n)) = a + b(n‐1) + cSCNE + dItg, where Itg is the terminal effect and its attenuation coefficient is 1/n. The results show that this equation is more accurate to express the Tb change of homologs RX than the NPOH equation in our previous paper. The parameter Itg has important influence on the Tb of RX, while it has less influence on the Tb of homologs α,ω‐disubstituted alkanes XRX and can be ignored. The Tb changes of 15 homologs RX and homolog alkane can be expressed using a general equation (Equation 11 in text). The effect of intramolecular charge‐induced dipole μind on the boiling point of homologs RX cannot be ignored.
Improving early phase oncology clinical trial design: An opportunity for statisticians
Authors: Phillips Alan , Mondal Shalini 
Published: December 2022

AbstractThis short communication supports that rule‐based study designs such as the ‘3 + 3’ study design are still being used in early phase oncology development programs despite their inferior performance to model‐based and model‐assisted designs. Statisticians have an opportunity to shape and improve early phase oncology drug development programs by introducing newer, more efficient study designs that estimate the Optimal Biological dose to their oncology trialist colleges.
Frequency‐domain‐based iterative learning control utilizing n‐best adaptive Fourier decomposition for nonrepetitive unknown iteration‐independent and iteration‐varying discrete time‐delay systems
Authors: Wen‐Yuan Fu 
Published: December 2022

AbstractThe bulk of well‐known control techniques for time‐delay systems are sensitive to the system's uncertainty. For unknown nonrepetitive iteration‐independent and iteration‐varying linear discrete time‐delay (LDTD) systems, an iterative learning control (ILC) design with a frequency domain identification technique is devised. The proposed ILC method is based on a novel n‐best adaptive Fourier decomposition (n‐BAFD) approach for approximating the unknown time‐delay transfer function. An extended anticipatory ILC law is developed that uses anticipatory time to compensate for both iteration‐independent and iteration‐varying time delays in the frequency domain for unknown nonrepetitive LDTD systems. Three examples are used to validate the proposed frequency‐domain‐based ILC method.
Confidence in COVID‐19 vaccines moderates the association between vaccination status and mental distress
Authors: Tan Chee Meng , Owuamalam Chuma , Sarma Vengadeshvaran J. , Ng Pek Kim 
Published: December 2022

AbstractPrevious research has demonstrated that becoming vaccinated with the Coronavirus vaccine may lower mental distress. However, it remains uncertain whether this relationship holds amid concerns of vaccine side effects and doubts of the vaccine's protective capabilities. We presented three studies that showed how vaccine confidence negatively influences the relationship between vaccine uptake and mental distress. Using two‐way fixed effects regression models, Study 1 analyzes longitudinal survey of respondents from Los Angeles County in the US, while Study 2 uses the same analytical strategy but generalises findings by analysing longitudinal data of participants across all 50 US states. Main results of both studies show that (i) vaccination uptake is linked with reduced mental distress among individuals with high vaccine confidence (ii) vaccine uptake has no effect on mental distress among individuals with low vaccine confidence. Lastly, Study 3 applies multilevel analysis to a large‐scale pseudo‐panel study of 15 developed countries. Results for the third study corroborate finding (i) but not (ii) in that the multinational study finds that vaccine uptake is actually associated with higher mental distress among individuals with low vaccine confidence. In sum, our paper shows that the palliative effect of vaccination on mental health only exists when vaccine confidence is high. Results are mixed on whether vaccination affects mental distress when individual vaccine confidence is low.