bluuebunny/crossref_metadata_2025_split huggingface dataset:
From infection to autoimmunity: ZnT8-mediated molecular mimicry in the triggering of post-COVID 19 type 1 diabetes mellitus
Authors: Andrade Luis Jesuino de Oliveira , de Oliveira Luisa Correia Matos , de Oliveira Gabriela Correia Matos , Silva Catharina Peixoto , de Oliveira Luís Matos 
Published: September 2023

Abstract
Introduction
The potential etiology of post-COVID-19 type 1 diabetes (DM1) being linked to the development of anti-Zinc Transporter 8 antibodies (ZnT8A) through molecular mimicry presents a compelling avenue for investigation, yet there remains a notable gap in our understanding of this field. While studies have revealed the presence of these autoantibodies in individuals with post-COVID-19 diabetes, the precise mechanisms by which the viral infection triggers the production of anti-ZnT8A antibodies are not yet fully comprehended.
Objective
To assess the molecular mimicry between the ZnT8 protein and proteins of the COVID-19 virus, as well as its potential impact on the initiation of DM1.
Methods
For this study, amino acid sequences of ZnT8 and COVID-19 proteins were obtained from UniProt databases. Protein structure data for ZnT8 and COVID-19 proteins were acquired from Swiss-Model. Multiple sequence alignment using VectorBuilder was performed to analyze similarities and conserved regions between the proteins. Pairwise Structure Alignment was used to assess the three-dimensional alignment of ZnT8 and COVID-19 proteins.
Results
The similarity results between ZnT8 and COVID-19 proteins are as follows: 1. ZnT8_HUMAN and SPIKE_SARS2: similarity of 16.67%; 2. ZnT8_HUMAN and VME1_SARS2: similarity of 26.37%; 3. ZnT8 protein and VEMP_SARS2 Envelope small membrane protein: similarity of 11.26%; and 4. ZnT8 protein and A0A883GPN5_SARS2 Nucleoprotein: similarity of 32.94%.
Conclusion
Based on the results obtained, it can be concluded that there is a level important of molecular mimicry between the ZnT8 protein and certain proteins of the COVID-19 virus. These findings provide insights into the potential impact of this molecular mimicry on the trigger of DM1.
A comparative analysis of polyomaviruses Large Tumor Antigens reveals evolution of different importin α-dependent nuclear localization signals
Authors: Alvisi Gualtiero , Cross Emily , Akbari Nasim , Ghassabian Hanieh , Hoad Mikayla , Pavan Silvia , Ariawan Daryl , Donnelly Camilla , Lavezzo Enrico , Petersen Gayle , Forwood Jade 
Published: September 2023

Abstract
Nucleocytoplasmic transport is a fundamental eukaryotic process that regulates the passage of proteins between the nucleus and cytoplasm, crucial for maintaining cellular homeostasis, gene expression, and signal transduction. In the best characterized pathway, importin (IMP) α bridges cargoes bearing basic, classical nuclear localization signals (cNLSs) to IMPβ1, which mediates transport through the nuclear pore complex. IMPα recognizes three types of cNLSs via two binding sites: the major binding site accommodates monopartite cNLSs, the minor binding site recognizes atypical cNLSs, whilst bipartite cNLSs simultaneously interact with both major and minor sites. Despite the growing knowledge regarding IMPα-cNLS interactions, our understanding of the evolution of cNLSs is limited. We combined bioinformatic, biochemical, functional, and structural approaches to study this phenomenon, using polyomaviruses (PyVs) large tumor antigens (LTAs) as a model. We characterized functional cNLSs from all human (H)PyV LTAs, located between the LXCXE motif and origin binding domain. Surprisingly, the prototypical SV40 monopartite NLS is not well conserved: HPyV NLSs are extremely heterogenous in terms of structural organization, IMPα isoform binding, and nuclear targeting abilities, thus influencing the nuclear accumulation properties of full-length proteins. While several LTAs possess bipartite cNLSs, Merkel cell (MC) PyV contains a hybrid bipartite cNLS whose upstream stretch of basic amino acids can function as an atypical cNLS, specifically binding to the IMPα minor site upon deletion of the downstream amino acids after viral integration in the host genome. We suggest that duplication of a monopartite cNLS and subsequent accumulation of point mutations, optimizing interaction with distinct IMPα binding sites, led to the evolution of bipartite and atypical NLSs binding at the minor site.
Высокотемпературная теплоемкость Li, Sc-германата LiScGeO-=SUB=-4-=/SUB=- и Li, Sc-силиката LiScSiO-=SUB=-4-=/SUB=-
Authors: Иртюго Л.А. , Денисова Л.Т. , Васильев Г.В. , Денисов В.М. 
Published: September 2023

LiScGeO 4 and LiScSiO 4 compounds were obtained by solid-phase synthesis from
Li 2 CO 3 , Sc 2 O 3 , GeO 2 (SiO 2 ). Their crystal structure has been refined using X-ray diffraction. The
high-temperature heat capacity (320–1050 K) of the obtained lithium-scandium germanate and
silicate was measured by differential scanning calorimetry. The thermodynamic properties were
calculated based on the experimental data about heat capacity.
Deuteronomistyczna koncepcja konfrontacji Eliasza z Achabem. Studium historyczno-krytyczne 1 Krl 17, 1; 18, 1–2. 41–46
Authors: Pikuliński Patryk 
Published: September 2023

W artykule przyjrzano się fragmentowi cyklu o Eliaszu metodą historyczno-krytyczną. Celem było przeanalizowanie relacji proroka do króla na podstawie trzech fragmentów (1
Krl 17, 1; 18, 1–2. 41–46), które przestawiają ich interakcję. Hipotezą tekstu było założenie istnienia jednej, archaicznej tradycji, do której należały wyżej wymienione fragmenty. Nie wpisują się one bowiem w obraz interakcji Eliasza z Achabem, wynikający z kontekstu (16, 29–34; 18, 17–20; 21, 17–29), gdzie król ukazany jest jako zły i bezbożny władca, będący w konfrontacji z prorokiem. Z omawianych fragmentów wywnioskować można neutralną lub nawet pozytywną relację pomiędzy tymi postaciami. Ponadto należy wskazać na konfrontację z baalizmem, obecnym już w archaicznej warstwie tekstu i bardzo uwydatniony w jego ostatecznej formie. Zgodnie z zastosowaną metodą przeanalizowany został kontekst (bliższy i dalszy) fragmentów, została przeprowadzona ich analiza literacka, krytyka tekstu, egzegeza oraz przyjrzano się teologii z nich wynikającej. Po przeanalizowaniu tekstów można stwierdzić istnienie jednej, predeuteronomistycznej tradycji, która została w czasie kilkakrotnie przeredagowana i uzupełniona, aby pasowała do deuteronomistycznej wizji.
Enhancing the Predictive Power of Google Trends Data Through Network Analysis: Infodemiology Study of COVID-19
Authors: Chu Amanda MY , Chong Andy C Y , Lai Nick H T , Tiwari Agnes , So Mike K P 
Published: September 2023

Background
The COVID-19 outbreak has revealed a high demand for timely surveillance of pandemic developments. Google Trends (GT), which provides freely available search volume data, has been proven to be a reliable forecast and nowcast measure for public health issues. Previous studies have tended to use relative search volumes from GT directly to analyze associations and predict the progression of pandemic. However, GT’s normalization of the search volumes data and data retrieval restrictions affect the data resolution in reflecting the actual search behaviors, thus limiting the potential for using GT data to predict disease outbreaks.

Objective
This study aimed to introduce a merged algorithm that helps recover the resolution and accuracy of the search volume data extracted from GT over long observation periods. In addition, this study also aimed to demonstrate the extended application of merged search volumes (MSVs) in combination of network analysis, via tracking the COVID-19 pandemic risk.

Methods
We collected relative search volumes from GT and transformed them into MSVs using our proposed merged algorithm. The MSVs of the selected coronavirus-related keywords were compiled using the rolling window method. The correlations between the MSVs were calculated to form a dynamic network. The network statistics, including network density and the global clustering coefficients between the MSVs, were also calculated.

Results
Our research findings suggested that although GT restricts the search data retrieval into weekly data points over a long period, our proposed approach could recover the daily search volume over the same investigation period to facilitate subsequent research analyses. In addition, the dynamic time warping diagrams show that the dynamic networks were capable of predicting the COVID-19 pandemic trends, in terms of the number of COVID-19 confirmed cases and severity risk scores.

Conclusions
The innovative method for handling GT search data and the application of MSVs and network analysis to broaden the potential for GT data are useful for predicting the pandemic risk. Further investigation of the GT dynamic network can focus on noncommunicable diseases, health-related behaviors, and misinformation on the internet.
Glucocentric and cardiocentric approaches to achieving type 2 diabetes compensation
Authors: Pankiv V.I. 
Published: September 2023

Background. Monotherapy for type 2 diabetes (T2DM) has been found to be effective only for a limited time. At the same time, the rationality of drug combinations remains an important component of successful management of T2DM. In this context, given the complex multifactorial pathogenesis of T2DM, it is optimal to influence various mechanisms of hyperglycemia. The purpose of the study is to determine the effectiveness and safety of additional administration of a combination of metformin and glimepiride in patients with type 2 diabetes with a glycated hemoglobin (HbA1c) level of 8.5–9.5 % who took dapagliflozin alone for at least three months. Materials and methods. Fourteen men (mean age 57.9 ± 8.4 years) and 18 women (mean age 58.2 ± 9.3 years) with T2DM were included in the study. The average duration of T2DM was 9.7 ± 4.2 years. The patients were in a state of decompensation of T2DM (HbA1c over 8.5 %) against the background of dapagliflozin monotherapy in the maximum dose for at least three previous months. In addition to dapagliflozin (10 mg/day), patients were prescribed a combination of metformin and glimepi­ride (Duglimax tablets, 500 mg/2 mg once a day) for three months. Results. The average level of HbA1c in 32 patients with T2DM was 9.72 ± 0.81 %, fasting plasma glucose was 10.71 ± 1.42 mmol/l. Three months after the start of a combined treatment, the HbA1c level decreased significantly to 7.54 ± 0.46 % (p < 0.05). The average reduction in HbA1c after switching to additional metformin therapy with glimepiride was 1.48 ± 0.38 %. The proportion of patients who achieved HbA1c < 7.5 % was 34.5 % after 3 months (p < 0.05). The effectiveness of the additional administration of metformin and glimepiride is also confirmed by the high percentage of patients (12.5 %) who achieved HbA1c < 7.0 % (p < 0.05). The level of fas­ting plasma glucose decreased to an average of 7.19 ± 1.06 mmol/l after 3 months. The average decrease reached 3.06 ± 1.08 mmol/l, which in relative terms was 31.4 ± 8.7 % of baseline. No cases of hypoglycemia or other adverse events were registered during the entire study period. Conclusion. The analysis of indicators in 32 patients with type 2 diabetes who had a high level of HbA1c (over 9 %) against the background of dapagliflozin monotherapy allowed us to conclude that it is necessary to intensify the therapy by additionally prescribing a combination of metformin and glimepiride for achieving the target levels of HbA1c. Glucocentric and cardiocentric views on T2DM can be reconciled and integrated by using a combination therapy to address the different etiopathological features of the disease from the very beginning of treatment.
The correlation between body weight, serotonin levels, mental health status, sleep disorders and metabolism in patients with obesity
Authors: Tkachenko V.I. , Bagro T.O. 
Published: September 2023

Background. The significant spread of obesity stimulates researchers to search for etiopathogenic treatment by studying the relationships and dependencies of the hormonal, neurochemical and psychosomatic components. The purpose of the study is to determine the correlation between body weight, serotonin level, mental health status, sleep disorders and metabolism in obese patients. Materials and methods. In a cohort, prospective study, 75 patients with obesity were observed for 6 months. They were divided into 2 groups depending on the detected psychosocial characteristics and sleep disorders with the appropriate treatment using a patient-oriented approach. The examination included studying body mass index (BMI), abdominal obesity indices (body surface area, waist/hip ratio, conicity index, a body shape index, abdominal volume index), blood pressure, lipid profile, fasting glucose, insulin, leptin, serotonin, assessment of psychosocial status and sleep quality with Hospital Anxiety and Depression Scale (HADS), Beck’s Depression Inventory (BDI), Hamilton Anxiety Rating Scale (HAM-A), Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), quality of life using the SF-36 questionnaire. Statistical analysis was performed using IBM SPSS Statistics, Statistica 12, Excel 2010. Results. At baseline, the patients had obesity class I and II. Тhe calculated indices of abdominal obesity, indicators of lipid and carbohydrate metabolism, scores of questionnaires of eating behavior, anxiety and depression, quality of sleep, sleepiness and leptin level exceeded the recommended values, while the level of serotonin, the scores of the SF-36 had low values that significantly improved in dynamics. Strong direct correlations at baseline were found between BMI, abdominal obesity indices, blood pressure, indicators of lipid and carbohydrate metabolism, leptin, HADS, BDI, HAM-A, ESS, PSQI global score; a strong inverse (negative) relationship was noted between BMI and the levels of high-density lipoprotein and serotonin. A high negative correlation was found between serotonin and BMI, abdominal obesity indices (body surface area, a body shape index, abdominal volume index, conicity index), blood pressure, indicators of lipid and carbohydrate metabolism, HADS, HAM-A, BDI, PSQI global score, sleep quality, latency, duration, efficiency and the ESS. Conclusions. The high BMI correlates with a low level of serotonin, increased level of anxiety and depression, drowsiness, deterioration of the quality of sleep and life, disorders of lipid and carbohydrate metabolism, which are mutually aggravating factors for the development of obesity and other non-infectious diseases; it must be taken into account when determining approaches to comprehensive patient-oriented treatment of obesity.
Dynamics of Symbols in Romantic and Neo-Romantic Poets: A Study of Some Selected Poems of William Blake, William Wordsworth, Ted Hughes and Seamus Heaney
Authors: Tata Delphine Esi , Neba Divine Che 
Published: September 2023

In literary discourse, symbolism is the use of objects to signify ideas and qualities. Consequently, symbols take varied forms to convey these ideas, concepts or emotions, explicitly, and implicitly, relying on shared cultures or conventions. On this note, this paper underscores that there is a shift in the dynamics of symbols from the romantic epoch to the postmodern period with each era portraying nature and childhood symbols in a manner that is satisfactory to humanity across ages. The paper also shows that though the Romantics (William Blake and William Wordsworth) and Neo-romantics, (Ted Hughes and Seamus Heaney) share similar concerns in relation to nature and childhood, these consternations are read through different prisms. In this light, they plunge into the ambiguities of the imagination and the changing consciousness, from a quiet romantic time to the traumatic epoch of the 21st century. To Blake, Wordsworth, Hughes, and Heaney, imagination, as such, remains a gift, as it enables them to sail beyond the ordinary. Against this backdrop, the romantic and postmodern theoretical paradigms become inevitable as they pave the way for a better insight into the distinct styles of these poets in the exploration of space, time, thoughts, and other constituents through vibrant symbols to transcend the ordinary for a better portrait of nature and childhood.
Peran Sanggar Karawitan Rumah Budaya Sekar Tanjung Gunung Terhadap Masyarakat di Desa Segawe Kecamatan Pagerwojo Tulungagung
Authors: Rahma Erika Yuliani , Hendriani Dita 
Published: September 2023

Abstrak
Penelitian ini dilatarbelakangi oleh maraknya kelompok-kelompok karawitan yang berlatih di Sanggar Karawitan Rumah Budaya Sekar Tanjung Gunung. Sanggar tersebut memiliki tujuan guna melestarikan serta mengembangkan seni budaya lokal dari masyarakat Desa Segawe. Peneliti melihat indikasi keterlibatan Sanggar Karawitan Rumah Budaya Sekar Tanjung Gunung terhadap masyarakat Desa Segawe. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian lapangan dengan pendekatan kualiatif. Pengumpulan data dilakukan dengan teknik observasi, wawancara, dan dokumentasi. Hasil penelitian ini adalah 1) sejarah Sanggar Karawitan Rumah Budaya Sekar Tanjung Gunung awalnya didirikan oleh Bapak Suharno pada tahun 2019 sebagai apresiasi terhadap kesuksesan kesenian karawitan di Desa Segawe, sanggar tersebut saat ini dipimpin oleh Bapak Markup. Pada saat ini jumlah kelompok karawitan yang tergabung dalam sanggar sebanyak 6 kelompok 2) peran Sanggar Karawitan Rumah Budaya Sekar Tanjung Gunung terhadap masyarakat di Desa Segawe yaitu: sebagai wadah pengembangan bakat/minat, sebagai fasilitator, sebagai motivator organisasi, sebagai mitra kerjasama, sebagai sarana memperoleh penghasilan tambahan, sebagai sarana hiburan, sebagai wadah pendidikan luar sekolah, dan sebagai sarana dalam melestarikan budaya

Kata Kunci: Masyarakat, Peran, Sanggar Karawitan
PONDOK PESANTREN NURUL HUDA (NW) DI DESA SUBGAN, KARANGASEM, BALI KAJIAN TENTANG SEJARAH DAN NILAI PENDIDIKAN KARAKTER DI SMA/MA
Authors: Bintang Prakasa  , Maryati Tuty , Yasa I Wayan Putra 
Published: September 2023

Abstrak
​Penelitian ini bertujuan untuk mengetahui: Sejarah berdirinya Pondok Pesantren Nurul Huda, Sistem Pendidikan Pondok Pesantren Nurul Huda, Potensi Pondok PesantrenNurul Huda yang dapat digunakan sebagai sumber belajar dan nilai Pendidikan Karakter di SMA/MA. Penelitian inimerupakan penelitian kualitatif. Metode yang digunakanadalah metode penelitian sejarah melalui beberapa langkahyakni, heuristik ( teknik penentuan informan, observasi, studidokumen dan wawancara), interpretasi dan historiografi. Data yang terkumpul dianalisis secara kualitatif dengan model analisis Miles dan Huberman. Hasil penelitian menunjukkan,Pondok Pesantren Nurul Huda berdiri pada tahun 1965 yang diusulkan oleh Abdul Karim melalui kesepakatan wargasekitar, Struktur kurikulum Pondok Pesantren Nurul Huda inimeliputi ranah pengembangan kognitif, affective, dan psikomotor santri dan santriwati dan nilai nilai PondokPesantren sebagai pendidikan karakter di SMA/MA adalahnilai toleransi, nilai religius, nilai kejujuran, nilai tolong-menolong, nilai kerja keras, nilai disiplin.
Kata kunci: media pembelajaran, pendidikan karakter, sistem pendidikan
PENGEMBANGAN MEDIA KOMIK DIGITAL DALAM PEMBELAJARAN SEJARAH BERBASIS KEARIFAN LOKAL NYAMA BALI-NYAMA SELAM UNTUK MENINGKATKAN TOLERANSI BERAGAMA DI SMA NEGERI 4 SINGARAJA
Authors: Ni Putu Ristiana Rahitasari  , Ketut Sedana Arta  , I Wayan Pardi  
Published: September 2023

Penelitian ini bertujuan untuk meneliti dampak penerapan media komik digital berbasis kearifan lokal Nyama Bali-Nyama Selam terhadap peningkatan toleransi beragama siswa SMA Negeri 4 Singaraja. Penelitian dan Pengembangan (R & D). Pengembangan media pembelajaran komik berbasis budaya lokal Nyama Bali-Nyama Selam dilaksanakan dengan mengadopsi metode R & D dari Borg and Gall, yaitu: (1) studi pendahuluan, (2) pengembangan dan perancangan produk, (3) pengujian produk. Penelitian ini dilaksanakan bulan Agustus-Oktober 2022 dengan alokasi waktu selama 3 bulan, yang diawali dengan tahap persiapan, pelaksanaan, analisis data sampai penyusunan laporan. Uji coba media komik digital akan dilaksanakan di SMA Negeri 4 Singaraja, Kabupaten Buleleng, Provinsi Bali. Produk media komik digial menghasilkan 5 epidode yang terdiri dari 20-40 panel didalam satu episode, selain itu juga terdapat satu episode yang digunakan untuk mengenalkan tokoh utama. Dimana media akan menjadi alternatif sumber belajar yang menyenangkan. Validitas media komik digital memperoleh hasil sebesar 4, 30 untuk uji validitas ssehingga berdasarkan tabel dapat dikategorikan sangat valid sebagai sebuah media pembelajaran yang digunakan di kelas. Hasil dari penelitian juga diperoleh hasil dimana berdasarkan hasil uji coba kelompok kecil dan juga perorangan diperoleh hasil dengan indikator sangat praktis dimana diperoleh hasil dari uji coba perorangan dan kelompok kecil. Hasil uji dari statistik menunjukkan data bersifat homogen dan berdisribusi normal. Beranjak dari uji homogenitas yang dilanjutkan kepada statistik parametrik yang memperoleh hasil uji T Hitung sebesar 0.970 maka terdapat pengaruh yang signifikan yang hampir sempurna diantara variabel penerapan media pembelajaran komik digital The Hanging Enclaves terhadap toleransi siswa SMA Negeri 4 Singaraja. Berdasarkan tabel kriteria keeratan hubungan 0,970 terletak dalam kategori sangat erat.

Kata kunci: Media Pembelajaran, Komik Digital, Sejarah Masuknya Islam
Fabrication Challenges in Synthesizing Porous Ceramic Membrane to Effective Flue Gas Treatment
Authors: Rahman Ihsan Ur , Mohammed Hamin Jaafar , Ullah Misbah , Tayyeb Muhammad , Siddique Muhammad Farooq 
Published: September 2023

Global warming is a serious concern worldwide, while there are many contributors to rise the temperature of earth. One major source to it, is air pollution. It is of utmost importance to apply the necessary remedial actions to address the contaminants in outdoor and indoor environment. In this research a step is taken to treat flue gases, for which membrane technology is introduced. A porous ceramic membrane is synthesized from calcined porous alumina (Al2O3) and activated washed fly ash. Some other additives like starch (C6H10O5) n, binder solution along with ethyl silicate (C8H2O4Si) and a deflocculating agent carbonic acid (H2CO3), are employed. Alongside it, some of the issues are discussed which are faced during fabrication of porous ceramic membrane i.e., crakes in membrane sample, non-active reactants issue, un-even rise or fall during de-moisturization or sintering steps. Further, the membrane sample is characterized through different test including: Further, the membrane sample is characterized through different test including thermogravimetric analysis (TGA) and DTG, which shown a satisfactory results, as there is negligible percentage weight loss after 750°C. X-ray fluorescence (XRF) for fly ash portrayal and X-ray diffraction (XRD) analysis for structure assessing are conducted, which described that the fabricated membrane has a crystalline structure as like ceramic. Archimedes Principal technique is used to determine bulk density, and porosity of the membrane sample, the values are 4.484 g/cm3, and 62.5% respectively. Average pore size of 7.6 µm is find out through optical microscopy test, similarly mechanical strength is found to be 2.7 MPa. Furthermore, a pilot scale visual permeability test is performed for flue gases treatment of combusting fuel containing tyre and coal powder. The results show the compatibility of the fabricated porous ceramic membrane to be utilized for treatment of flue gases.