bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exogenous IL‐10 posttreatment along with TLR4 and TNFR1 blockade improves tissue antioxidant status by modulating sepsis‐induced macrophage polarization
Authors: Sawoo Ritasha , Dey Rajen , Ghosh Rituparna , Bishayi Biswadev 
Published: May 2023

AbstractMulti‐organ dysfunction is one of the major reasons behind the high mortality of sepsis throughout the world. With the pathophysiology of sepsis remaining largely unknown, the uncontrolled reactive oxygen species (ROS) production along with the decreased antioxidants contributes to the progression toward septic shock. Being the effector cells of the innate immunity system, macrophages secrete both pro‐inflammatory and anti‐inflammatory mediators during inflammation. Lipopolysaccharide (LPS) binding to toll‐like receptor 4 (TLR4) releases TNF‐α, which initiates pro‐inflammatory events through tumor necrosis factor receptor 1 (TNFR1) signaling. However, it is counteracted by the anti‐inflammatory interleukin 10 (IL‐10) causing decreased oxidative stress. Our study thus aimed to assess the effects of exogenous IL‐10 treatment post‐neutralization of TLR4 and TNFR1 (by anti‐TLR4 antibody and anti‐TNFR1 antibody, respectively) in an in vivo murine model of LPS‐sepsis. We have also examined the tissue‐specific antioxidant status in the spleen, liver, and lungs along with the serum cytokine levels in adult male Swiss albino mice to determine the functional association with the disease. The results showed that administration of recombinant IL‐10 post‐neutralization of the receptors was beneficial in shifting the macrophage polarization to the anti‐inflammatory M2 phenotype. IL‐10 treatment significantly downregulated the free radicals production resulting in diminished lipid peroxidase (LPO) levels. The increased antioxidant activities of superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GRX) conferred protection against LPS‐induced sepsis. Western blot data further confirmed diminished expressions of TLR4 and TNFR1 along with suppressed stress‐activated protein kinases/Jun amino‐terminal kinases (SAPK/JNK) and increased SOD and CAT expressions, which altogether indicated that neutralization of TLR4 and TNFR1 along with IL‐10 posttreatment might be a potential therapeutic measure for the treatment of sepsis.
School counseling prevention programming to address social determinants of mental health
Authors: Johnson Kaprea F. , Kim Hyunhee , Molina Citlali E. , Thompson Kaleb A. , Henry Sarah , Zyromski Brett 
Published: May 2023

AbstractSocial determinants of mental health (SDOMH) are conditions in which students live that significantly contribute to their mental health challenges. School counselors can utilize the Advocating Student‐within‐Environment (ASE) theoretical lens as a liberation approach to strengthening students’ capacity to overcome persistent adversity while addressing root causes of systemic oppression through policy change and advocacy at the school, community, and national levels. School counselors can use increased personal awareness of the oppressive nature of SDOMH and the bidirectional approach offered by ASE to influence systems and students through preventative programming and proactive advocacy to affect institutional change. This study provides school counselors with an overview of ASE as a theoretical foundation for addressing SDOMH in schools.
Social determinants of mental health: Informing counseling practice and professional identity
Authors: Pester Danielle A. , Jones Laura K. , Talib Zohray 
Published: May 2023

AbstractThe counseling field, with its grounding in wellness, social justice, and development, is well positioned to adopt a social determinants of mental health framework and lead initiatives to further integrate this type of framework into the larger mental health field. The purpose of this article is to bring together and apply two existing models, the social determinants of mental health and the social determinants of mental disorders, to the field of professional counseling. The authors argue that by adopting this framework, professional counselors will be better positioned to identify and address social determinants of mental health both proximal and distal to their clients and use this to inform direct clinical practice, the design and evaluation of counselor training programs, the development of community‐based intervention programs, counseling research, as well as policy initiatives ranging from the organizational to public policy levels.
Bonding and stability of elusive silaboryne (SiB) and germaboryne (GeB) with donor base ligands
Authors: Das Sujit , Devi Kavita , Suthar Sonam , Mondal Kartik Chandra 
Published: May 2023

AbstractStabilizing the exotic chemical species possessing multiple bonds is often extremely challenging due to insufficient orbital overlap, especially involving one heavier element. Bulky aryl groups and/or carbene as ligand have previously stabilized the SiSi, GeGe, and BB triple bonds. Herein, theoretical calculations have been carried out to shed light on the stability and bonding of elusive silaboryne/germaboryne (Si/GeB triple bond) stabilized by donor base ligands ((cAAC)BE(Me)(L); E = Si, L = cAACMe, NHCMe, PMe3; E = Ge, L = cAACMe). The heavier analogues (Sn, Pb) have been further studied for comparison. Additionally, the effects of bulky substituents at the Si and N atoms on the structural parameters and stability of those species have been investigated. Energy decomposition analysis coupled with natural orbital for chemical valence (EDA‐NOCV; for Si) showed that cAAC/NHC ligands could stabilize the exotic BSi‐Me species more efficiently than PMe3 ligands. The BSi partial triple bond of the corresponding species possesses a mixture of one covalent electron sharing BSi σ‐bond and two dative π‐bonds (B ← Si, B → Si).
Impact of Lisinopril on Cardiometabolic Risk Factors in Sisters of Women With Polycystic Ovary Syndrome
Authors: Krysiak Robert , Kowalcze Karolina , Okopień Bogusław 
Published: May 2023

AbstractWomen with polycystic ovary syndrome (PCOS), the most common endocrinopathy in reproductive age, are characterized by increased cardiometabolic risk. Similar hormonal and metabolic changes were found in their siblings. The purpose of our study was to compare blood pressure–lowering and pleiotropic effects of lisinopril between sisters of women with PCOS and their unrelated peers. The study included two age‐, body mass index–, and blood pressure–matched groups of women with grade 1 hypertension: 26 sisters of PCOS probands (Group 1) and 26 individuals without a family history of PCOS (Group 2), receiving 10–40 mg of lisinopril daily. Blood pressure, glucose homeostasis markers, plasma levels of lipids (androgens, estradiol, high‐sensitivity C‐reactive protein (hsCRP), homocysteine, fibrinogen, and uric acid), and urinary albumin‐to‐creatinine ratio (UACR) were measured before lisinopril treatment and 6 months later. At baseline, the study groups differed in insulin sensitivity, testosterone, free androgen index (FAI), hsCRP, homocysteine, and UACR. Blood pressure–lowering properties of lisinopril did not differ between the groups. The decrease in homocysteine and UACR, although observed in both groups, was stronger in Group 2 than in Group 1. Only in women without a family history of PCOS lisinopril improved insulin sensitivity and reduce hsCRP, fibrinogen, and uric acid. The remaining markers did not change throughout the study. Cardiometabolic effects of lisinopril correlated with testosterone, free androgen index, and changes in insulin sensitivity. The obtained results suggest that cardiometabolic effects of lisinopril may be slightly less pronounced in sisters of women with PCOS than in women without a family history of this disorder.
DOAC Dosing Discordance Using Different Estimates of Kidney Function and Outcomes
Authors: Bhalodia Nauka J. , White Evan M. , Achanta Archita , Cheng Jesse , Deri Connor R. , Stahl Kelsey , Heiney Heather , Marchionda Olivia , Iasella Carlo J. , Coons James C. 
Published: May 2023

AbstractDirect oral anticoagulants (DOACs) are indicated for the prevention of stroke in nonvalvular atrial fibrillation. Although Food and Drug Administration labeling for DOACs uses estimated creatinine clearance according to the Cockcroft–Gault (C‐G) equation, estimated glomerular filtration rate according to the Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) equation is often reported. The objectives of this study were to evaluate DOAC dosing discordance and to determine whether discordance based on various estimates of kidney function is associated with bleeding or thromboembolism. The study was an institutional review board approved retrospective analysis of patients at UPMC Presbyterian Hospital from January 1, 2010, to December 12, 2016. Data were obtained through electronic medical records. Adults who received a medication charge for rivaroxaban or dabigatran, had a diagnosis code for atrial fibrillation, and had a serum creatinine within 3 days of DOAC initiation were included. Doses were considered discordant if the calculated dose based on CKD‐EPI did not match the patient's dose during index admission, if dosed correctly using C‐G. Association of discordance with dabigatran, rivaroxaban, and clinical outcomes was determined using odds ratios and 95% confidence intervals. Rivaroxaban discordance was present among 49 of the 644 (8%) patients who were dosed correctly with C‐G. Dabigatran discordance was present among 17 of the 590 (3%) patients who were dosed correctly. Discordance with rivaroxaban was found to increase the risk of thromboembolism when using CKD‐EPI (odds ratio, 2.83; 95% CI, 1.02–7.79, P = .045) versus C‐G. Our findings emphasize the need to dose DOACs, specifically rivaroxaban, appropriately in patients with nonvalvular atrial fibrillation.
Multi‐factorial investigation of the effect of biochar of the secondary medicinal residue of snow lotus on the adsorption of two azo dyes, methyl red and methyl orange
Authors: Zhang Sha , Yao Yanna , Li Junlong , Wang Linyang , Wang Xinyu , Tian Shuge 
Published: May 2023

AbstractAzo dye residues pollute water, which are difficult to decompose, and posing a major threat to the ecological environment. The residues of Chinese medicine still have many possibilities for use after its medicinal value has been brought into play. In this study, secondary residue biochar activation (Na2CO3‐modified, SBA) and secondary residue biochar (unmodified, SBC) were prepared from the secondary residue of snow lotus at 200–600°C. Surface features were obtained by Brunauer–Emmett–Teller N2 method and combined with scanning electron microscopy, and their structures were analyzed by x‐ray diffraction spectroscopy, Fourier infrared and near‐infrared spectroscopy. The effects of five factors, including initial concentration, contact time and adsorption temperature and so forth, on the adsorption of methyl red (MR) and methyl orange (MO) solutions were investigated. Results showed that the biochar yield, specific surface area, and pore size increased after modification. modification promoted the formation of the internal structure aromatization and oxygen‐containing functional groups. Adsorption experiments showed that the surroundings pH = 8, the dyes adsorption concentration of 8 mg/L, adsorption temperature of 20–40°C and time of about 1 h were more stable. Under the condition, the removal of MO by SBA could reach approximately 60%–80% (480–640 mg/g), while the removal of MR could reach more than 90% (>720 mg/g).The charcoal prepared and modified under high temperature conditions was more effective for MO adsorption, while MR relied on low temperature effectively. This study provides a new choice of adsorbent for MR and MO and finds a new direction for the utilization of snow lotus residues.
The potential risk associated with foodborne pathogens in a watershed: Escherichia coli O157:H7 in dairy cattle
Authors: Mohammed Hussni O. , McDonough Patrick L. , Chang Yung‐fu 
Published: May 2023

AbstractWe carried out an investigation to determine the occurrence of Escherichia coli O157:H7 in dairy herds in the Delaware County watershed and to identify the factors that play a role in the likelihood of presence of this organism among animals on these farms. The pathogen poses risk of environmental degradation and health to the inhabitants. A total of 2162 fecal samples were collected per rectum from a representative sample of cattle on 27 dairy farms. The samples were investigated for the presence of E. coli O157:H by initially enriching using a bacteriological media and detection of the pathogen using real‐time polymerase chain reaction technique. Escherichia coli O157:H7 was detected in 74% of the herds in the target population and in 3.7% of samples collected. An additional 54 animals were identified that were infected with O157 non‐H7 strains of E. coli among 15 farms. Several putative risk factors were associated with the detection of the pathogen on the enrolled farms included age, housing calves indoors, group housing for calves, housing calves in the calf barn, presence of dogs on the farm, and housing post‐weaned calves in a cow barn or heifer barn versus a greenhouse. In conclusion, E. coli O157:H7 was present on the dairy farms of Delaware County and may pose a threat to the people that live and work there. The risk associated with the detection of this pathogen could be reduced by adjusting management factors that were identified in this study.
Overlapping neurological phenotypes in two extended consanguineous families with novel variants in the CNTNAP1 and ADGRG1 genes
Authors: Khan Shazia , Umair Muhammad , Abbas Safdar , Ali Uroba , Zaman Gohar , Ansar Muhammad , Wang Rongrong , Zhang Xue , Houlden Henry , Harlalka Gaurav V. , Gul Asma 
Published: May 2023

AbstractBackgroundPopulation diversity is important and rare disease isolates can frequently reveal novel homozygous or biallelic mutations that lead to expanded clinical heterogeneity, with diverse clinical presentations.MethodsThe present study describes two consanguineous families with a total of seven affected individuals suffering from a clinically similar severe syndromic neurological disorder, with abnormal development and central nervous system (CNS) and peripheral nervous system (PNS) abnormalities. Whole exome sequencing (WES) and Sanger sequencing followed by 3D protein modeling was performed to identify the disease‐causing gene. RNA was extracted from the fresh blood of both families affected and healthy individuals.ResultsThe families were clinically assessed in the field in different regions of Khyber Pakhtunkhwa. Magnetic resonance imagining was obtained in the probands and blood was collected for DNA extraction and WES was performed. Sanger sequencing confirmed a homozygous, likely pathogenic mutation (GRCh38: chr17:42684199G>C; (NM_003632.3): c.333G>C);(NP_003623.1): p.(Trp111Cys) in the CNTNAP1 gene in family A, previously associated with Congenital Hypo myelinating Neuropathy 3 (CHN3; OMIM # 618186) and a novel nonsense variant in family B, (GRCh38: chr16: 57654086C>T; NC_000016.10 (NM_001370440.1): c.721C>T); (NP_001357369.1): p.(Gln241Ter) in the ADGRG1 gene previously associated with bilateral frontoparietal polymicrogyria (OMIM # 606854); both families have extended CNS and PNS clinical manifestations. In addition, 3D protein modeling was performed for the missense variant, p.(Trp111Cys), identified in the CNTNAP1, suggesting extensive secondary structure changes that might lead to improper function or downstream signaling. No RNA expression was observed in both families affected and healthy individuals hence showing that these genes are not expressed in blood.ConclusionsIn the present study, two novel biallelic variants in the CNTNAP1 and ADGRG1 genes in two different consanguineous families with a clinical overlap in the phenotype were identified. Thus, the clinical and mutation spectrum is expanded to provide further evidence that CNTNAP1 and ADGRG1 are very important for widespread neurological development.
The book history of Rona M. Fields's A Society on the Run (1973): A case study in the alleged suppression of psychological research on Northern Ireland
Authors: Miller Gavin 
Published: May 2023

AbstractThe US psychologist Rona M. Field's book A Society on the Run (1973) offered a psychological account of the nature and effects of the Northern Irish Troubles at their peak in the early 1970s. The book was withdrawn shortly after publication by its publisher, Penguin Books Limited, and never reissued. Fields alleged publicly that the book had been suppressed by the British state, a claim that has often been treated uncritically. Local Northern Irish psychologists suggested that the book was taken off the market because of its scientific deficiencies. Rigorous book‐historical investigation using Penguin editorial fields reveals, however, that what might appear to be a case of state suppression, or an instance of disciplinary boundary work, can be explained instead by the commercial interests and professional standards of a publisher keen to preserve its reputation for quality and reliability.
Synthesis and antiviral activity of 2‐substituted 4‐aminoquinoline and its analogous derivatives
Authors: Chirra Nagaraju , Udigala Govinda , Sinegubova Ekaterina O. , Nagineni Devendra , Bollikanda Rakesh Kumar , Esaulkova Yana L. , Muryleva Anna A. , Zarubaev Vladimir V. , Kantevari Srinivas 
Published: May 2023

AbstractHerein we describe an efficient Lewis acid‐mediated one‐pot synthesis of 2‐substituted 4‐aminoquinolines from commercially available anthranilonitriles and substituted acetophenones via a Friedlander type annulation reaction. The protocol avoids any transition metal catalysts, has a wide substrate scope, and exclusively produces 4‐aminoquinolines in excellent yields. Screening of all the new compounds for in vitro antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1) in MDCK cells revealed nine analogues with good virus‐inhibiting activity and a favorable toxicity profile. Among them, two compounds, 3a (IC50: 1.7 μM, SI = 30) and 3l (IC50: 4.0 μM, SI = 25) with higher potency are the best anti‐influenza hit analogues for further structural optimization.
A source of funding for illicit activities or a solution to crime? Evidence from remittance inflows to Jamaica
Authors: Kufuor Nana Kwabena , Williams Kevin 
Published: May 2023

AbstractCrime and remittance inflows are high in Jamaica, and there is a general anecdote that foreign‐based masterminds use remittances to fund crime. Yet, remittances represent a significant source of foreign income to alleviate financial constraints, which may pose a dilemma to policymakers. We find that remittances significantly reduce rape and carnal abuse and property crimes such as larceny and break‐ins but have no significant effect on armed crimes such as shooting, murder and robbery. Remittances decrease crime by raising consumption and employment, but also they increase crime by weakening democratic institutions. Overall, remittances reduce incidents of crime significantly.
A Cox Nomogram for Assessing Recurrence Free Survival in Hepatocellular Carcinoma Following Surgical Resection Using Dynamic Contrast‐Enhanced MRI Radiomics
Authors: Cao Xinshan , Yang Haoran , Luo Xin , Zou Linxuan , Zhang Qiang , Li Qilin , Zhang Juntao , Li Xiangfeng , Shi Yan , Jin Chenwang 
Published: May 2023

BackgroundThe prognosis of hepatocellular carcinoma (HCC) is difficult to predict and carries high mortality. This study utilized radiomic techniques with clinical examinations to assess recurrence in HCC.PurposeTo develop a Cox nomogram to assess the risk of postoperative recurrence in HCC using radiomic features of three volumes of interest (VOIs) in preoperative dynamic contrast‐enhanced MRI (DCE‐MRI), along with clinical findings.Study TypeRetrospective.Subjects249 patients with pathologically proven HCCs undergoing surgical resection at three institutions were selected.Field Strength/SequenceFat saturated T2‐weighted, Fat saturated T1‐weighted, and DCE‐MRI performed at 1.5 T and 3.0 T.AssessmentThree VOIs were generated; the tumor VOI corresponds to the area from the tumor core to the outer perimeter of the tumor, the tumor +10 mm VOI represents the area from the tumor perimeter to 10 mm distal to the tumor in all directions, finally, the background liver parenchyma VOI represents the hepatic tissue outside the tumor. Three models were generated. The total radiomic model combined information from the three listed VOI's above. The clinical–radiological model combines physical examination findings with imaging characteristics such as tumor size, margin features, and metastasis. The combined radiomic model includes features from both models listed above and showed the highest reliability for assessing 24‐month survival for HCC.Statistical TestsThe least absolute shrinkage and selection operator (LASSO) Cox regression, univariable, and multivariable Cox regression, Kmeans clustering, and Kaplan–Meier analysis. The discrimination performance of each model was quantified by the C‐index. A P value <0.05 was considered statistically significant.ResultsThe combined radiomic model, which included features from the radiomic VOI's and clinical imaging provided the highest performance (C‐index: training cohort = 0.893, test cohort = 0.851, external cohort = 0.797) in assessing the survival of HCC.ConclusionThe combined radiomic model provides superior ability to discern the possibility of recurrence‐free survival in HCC over the total radiomic and the clinical–radiological models.Evidence Level4.Technical EfficacyStage 2.
Evaluation of the late presentation and associated factors of people living with HIV in Turkey
Authors: Sevgi Dilek Yildiz , Demirbas Nazife Duygu , Genc Yaman Irem , Derin Okan , Oncul Ahsen , Atasoy Tahtasakal Ceren , Gul Ozlem , Diktas Husrev , Dokmetas Ilyas 
Published: May 2023

AbstractTo identify the frequency of late presentation and late presentation with advanced disease, and associated factors in people living with HIV (PLHIV). Data from PLHIV diagnosed between 2008 and 2021 were retrospectively analyzed. Time of diagnosis (categorized based on key events affecting HIV care continuum e.g., national strategies, HIV guidelines, COVID‐19 pandemic) and characteristics of late presenters (LP: CD4 ≤350 cells/mm³ or an AIDS defining event) and late presenters with advanced disease (LPAD: CD4 <200 cells/mm³) were describe. Associations between dependent (LP, LPAD) and independent variables were assessed using univariate/multivariate regression tests and presented as odds ratios (95% confidential interval). Of 1585 individuals (93.7% men), 42.5% were LPs and 19.3% were LPADs. Most common route of transmission was sex between men (54.3%). Non‐LPs were younger (30 vs. 34 and 36 years; p < 0.001) and included more men who have sex with men (60.3% vs. 46.3% and 39.5%; p < 0.001). Factors associated with being LP and LPAD were age >30 years, heterosexual/unknown route of transmission (vs. sex between men), diagnosis in 2008−2013 or 2020−2021, (vs. 2014−2019). With reference to Turkish subjects, migrants from Africa had higher odds of being LPAD. LP is still an important health issue in HIV care. Heterosexuality, older age (>30 years), migration from Africa, and the COVID‐19 pandemic are associated with delays in HIV presentation in Turkey. These factors need to be considered when developing and implementing policies to enable earlier diagnosis and treatment of PLHIV to achieve UNAIDS 95‐95‐95 targets.