bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Assembly of DNA Nanostructures in Different Cations
Authors: Rodriguez Arlin , Gandavadi Dhanush , Mathivanan Johnsi , Song Tingjie , Madhanagopal Bharath Raj , Talbot Hannah , Sheng Jia , Wang Xing , Chandrasekaran Arun Richard 
Published: June 2023

AbstractThe programmable nature of DNA allows the construction of custom‐designed static and dynamic nanostructures, and assembly conditions typically require high concentrations of magnesium ions that restricts their applications. In other solution conditions tested for DNA nanostructure assembly, only a limited set of divalent and monovalent ions are used so far (typically Mg2+ and Na+). Here, we investigate the assembly of DNA nanostructures in a wide variety of ions using nanostructures of different sizes: a double‐crossover motif (76 bp), a three‐point‐star motif (~134 bp), a DNA tetrahedron (534 bp) and a DNA origami triangle (7221 bp). We show successful assembly of a majority of these structures in Ca2+, Ba2+, Na+, K+ and Li+ and provide quantified assembly yields using gel electrophoresis and visual confirmation of a DNA origami triangle using atomic force microscopy. We further show that structures assembled in monovalent ions (Na+, K+ and Li+) exhibit up to a 10‐fold higher nuclease resistance compared to those assembled in divalent ions (Mg2+, Ca2+ and Ba2+). Our work presents new assembly conditions for a wide range of DNA nanostructures with enhanced biostability.
Capillary‐Scale Hydrogel Microchannel Networks by Wire Templating
Authors: Kawara Shusei , Cunningham Brian , Bezer James , KC Neelima , Zhu Jingwen , Tang Meng‐Xing , Ishihara Jun , Choi James J. , Au Sam H. 
Published: June 2023

AbstractMicrovascular networks are essential for the efficient transport of nutrients, waste products, and drugs throughout the body. Wire‐templating is an accessible method for generating laboratory models of these blood vessel networks, but it has difficulty fabricating microchannels with diameters of ten microns and narrower, a requirement for modeling human capillaries. This study describes a suite of surface modification techniques to selectively control the interactions amongst wires, hydrogels, and world‐to‐chip interfaces. This wire templating method enables the fabrication of perfusable hydrogel‐based rounded cross‐section capillary‐scale networks whose diameters controllably narrow at bifurcations down to 6.1 ± 0.3 microns in diameter. Due to its low cost, accessibility, and compatibility with a wide range of common hydrogels of tunable stiffnesses such as collagen, this technique may increase the fidelity of experimental models of capillary networks for the study of human health and disease.
Nonconventional Luminescent Piperazine‐Containing Hyperbranched Polysiloxanes with Pure n‐electron
Authors: Du Yuqun , Liu Yiwei , Li Jangwei , He Yanyun , Li Yanbin , Yan Hongxia 
Published: June 2023

AbstractNonconventional luminogens with high quantum yield (QY) possess very potential applications in various fields. However, the preparation of such luminogens remains a great challenge. Herein, the first example of piperazine‐containing hyperbranched polysiloxane exhibiting blue and green fluorescence is reported under the irradiation of different excitation wavelength and a high QY of 20.9%. The density functional theory (DFT) calculations and experimental results revealed that the through‐space conjugation (TSC) within the clusters of N and O atoms is produced via the induction of multiple intermolecular hydrogen bonds and flexible SiO units, which is accountable for the fluorescence. Meanwhile, the introduction of the rigid piperazine units not only rigidifies the conformation, but also enhances the TSC. In addition, the fluorescence of both P1 and P2 shows concentration‐, excitation‐, and solvent‐dependent emission, especially exhibits significant pH‐dependent emission and obtains an ultrahigh QY of 82.6% at pH 5. The synthetic luminogens show excellent applications in fluorescence detection for Fe3+ and Co2+, information encryption, and fluorescent film. This study provides a novel strategy to rationally design high‐efficiency nonconventional luminogens.
Oxalate‐Assisted Synthesis of Hollow Carbon Nanocage With Fe Single Atoms for Electrochemical CO2 Reduction
Authors: Yu Ke , Sun Kaian , Cheong Weng‐Chon (Max) , Tan Xin , He Chang , Zhang Jiaqi , Li Jiazhan , Chen Chen 
Published: June 2023

AbstractMetal single‐atom catalysts are promising in electrochemical CO2 reduction reaction (CO2RR). The pores and cavities of the supports can promote the exposure of active sites and mass transfer of reactants, hence improve their performance. Here, iron oxalate is added to ZIF‐8 and subsequently form hollow carbon nanocages during calcination. The formation mechanism of the hollow structure is studied in depth by controlling variables during synthesis. Kirkendall effect is the main reason for the formation of hollow porous carbon nanocages. The hollow porous carbon nanocages with Fe single atoms exhibit better CO2RR activity and CO selectivity. The diffusion of CO2 facilitated by the mesoporous structure of carbon nanocage results in their superior activity and selectivity. This work has raised an effective strategy for the synthesis of hollow carbon nanomaterials, and provides a feasible pathway for the rational design of electrocatalysts for small molecule activation.
Fluorinated Interface Engineering toward Controllable Zinc Deposition and Rapid Cation Migration of Aqueous Zn‐Ion Batteries
Authors: Feng Yuge , Wang Yaoda , Sun Lin , Zhang Kaiqiang , Liang Junchuan , Zhu Mengfei , Tie Zuoxiu , Jin Zhong 
Published: June 2023

AbstractMetallic zinc (Zn) is a highly promising anode material for aqueous energy storage systems due to its low redox potential, high theoretical capacity, and low cost. However, rampant dendrites/by‐products and torpid Zn2+ transfer kinetics at electrode/electrolyte interface severely threaten the cycling stability, which deteriorate the electrochemical performance of Zn‐ion batteries. Herein, an interfacial engineering strategy to construct alkaline earth fluoride modified metal Zn electrodes with long lifespan and high capacity retention is reported. The compact fluoride layer is revealed to guide uniform Zn stripping/plating and accelerate the transfer/diffusion of Zn2+ via Maxwell‐Wagner polarization. A series of in situ and ex situ spectroscopic studies verified that the fluoride layer can guide uniform Zn stripping/plating. Electrochemical kinetics analyses reveal that positive effect on the removal of Zn2+ solvation sheath provided by fluoride layer. Meanwhile, this fluoride coating layer can act as a barrier between the Zn electrode and electrolyte, providing a high electrode overpotential toward hydrogen evolution reaction to hold back H2 evolution. Consequently, the fluoride‐modified Zn anode exhibited a capacity retention of 88.2% after 4000 cycles under10 A g−1. This work opens up a new path to interface engineering for propelling the exploration of advanced rechargeable aqueous Zn‐ion batteries.
Water‐Induced Separation of Polymers from High Nanoparticle‐Content Nanocomposite Films
Authors: Kim Baekmin Q. , Füredi Máté , Venkatesh R. Bharath , Guldin Stefan , Lee Daeyeon 
Published: June 2023

AbstractPolymer nanocomposites with high loadings of nanoparticles (NPs) exhibit exceptional mechanical and transport properties. Separation of polymers and NPs from such nanocomposites is a critical step in enabling the recycling of these components and reducing the potential environmental hazards that can be caused by the accumulation of nanocomposite wastes in landfills. However, the separation typically requires the use of organic solvents or energy‐intensive processes. Using polydimethylsiloxane (PDMS)‐infiltrated SiO2 NP films, we demonstrate that the polymers can be separated from the SiO2 NP packings when these nanocomposites are exposed to high humidity and water. The findings indicate that the charge state of the NPs plays a significant role in the propensity of water to undergo capillary condensation within the PDMS‐filled interstitial pores. We also show that the size of NPs has a crucial impact on the kinetics and extent of PDMS expulsion, illustrating the importance of capillary forces in inducing PDMS expulsion. We demonstrate that the separated polymer can be collected and reused to produce a new nanocomposite film. The work provides insightful guidelines on how to design and fabricate end‐of‐life recyclable high‐performance nanocomposites.
Self‐Assemble Silk Fibroin Microcapsules for Cartilage Regeneration through Gene Delivery and Immune Regulation
Authors: He Shuangjian , Fu Xuejie , Wang Liang , Xue Yangyang , Zhou Long , Qiao Shigang , An Jianzhong , Xia Tingting 
Published: June 2023

AbstractEffective treatments for cartilage defects are currently lacking. Gene delivery using proper delivery systems has shown great potential in cartilage regeneration. However, the inflammatory microenvironment generated by the defected cartilage severely affects the system's delivery efficiency. Therefore, this study reports a silk fibroin microcapsule (SFM) structure based on layer‐by‐layer self‐assembly, in which interleukin‐4 (IL‐4) is modified on silk by click chemistry and loaded with lysyl oxidase plasmid DNA (LOX pDNA). The silk microcapsules display good biocompatibility and the release rate of genes can be adjusted by controlling the number of self‐assembled layers. Moreover, the functionalized SFMs mixed with methacrylated gelatin (GelMA) exhibit good injectability. The IL‐4 on the outer layer of the SFM can regulate macrophages to polarize toward the M2 type, thereby promoting cartilage matrix repair and inhibiting inflammation. The LOX pDNA loaded inside can be effectively delivered into cells to promote extracellular matrix generation, significantly promoting cartilage regeneration. The results of this study provide a promising biomaterial for cartilage repair, and this novel silk‐based microcapsule delivery system can also provide strategies for the treatment of other diseases.
Photo‐Induced Construction and Recovery of Cu+ Sites in Metal–Organic Frameworks
Authors: Li Yu‐Xia , Li Ke‐Di , Qian Xin‐Yu , Liu Xiao‐Qin , Sun Lin‐Bing 
Published: June 2023

AbstractThe adjustment of the valence state of metal ions is crucial for various applications because peculiar activity originates from metal ions with specific valence. Cu+ can interact with molecules possessing unsaturated bonds like CO via π‐complexation, while Cu2+ doesn't have such ability. Meanwhile, Cu+ sites are easily oxidized to Cu2+, leading to the loss of activity. Despite great efforts, the development of a facile method to construct and recover Cu+ sites remains a pronounced challenge. Here, for the first time a facile photo‐induced strategy is reported to fabricate Cu+ sites in metal–organic frameworks (MOFs) and recover Cu+ after oxidation. The Cu2+ precursor was loaded on NH2‐MIL‐125, a typical visible‐light responsive Ti‐based MOF. Visible light irradiation triggers the formation of Ti3+ from Ti4+ in framework, which reduces the supported Cu2+ in the absence of any additional reducing agent, thus simplifying the process for Cu+ generation significantly. Due to π‐complexation interaction, the presence of Cu+ results in remarkably enhanced CO capture capacity (1.16 mmol g−1) compared to NH2‐MIL‐125 (0.49 mmol g−1). More importantly, Cu+ can be recovered conveniently via re‐irradiation when it is oxidized to Cu2+, and the oxidation‐recovery process is reversible.
Hierarchical and Orderly Surface Conductive Networks in Yolk–Shell Fe3O4@C@Co/N‐Doped C Microspheres for Enhanced Microwave Absorption
Authors: He Peng , Ma Wenjun , Xu Jian , Wang Yizhe , Cui Zhong‐Kai , Wei Jie , Zuo Peiyuan , Liu Xiaoyun , Zhuang Qixin 
Published: June 2023

AbstractConstructing the adjustable surface conductive networks is an innovation that can achieve a balance between enhanced attenuation and impedance mismatch according to the microwave absorption mechanism. However, the traditional design strategies remain significant challenges in terms of rational selection and controlled growth of conductive components. Herein, a hierarchical construction strategy and quantitative construction technique are employed to introduce conductive metal–organic frameworks (MOFs) derivatives in the classic yolk–shell structure composed of electromagnetic components and the cavity for remarkable optimized performance. Specifically, the surface conductive networks obtained by carbonized ZIF‐67 quantitative construction, together with the Fe3O4 magnetic core and dielectric carbon layer linked by the cavity, achieve the cooperative enhancement of impedance matching optimization and synergistic attenuation in the Fe3O4@C@Co/N‐Doped C (FCCNC) absorber. This interesting design is further verified by experimental results and simulation calculations. The products FCCNC‐2 yield a distinguished minimum reflection loss of −66.39 dB and an exceptional effective absorption bandwidth of 6.49 GHz, indicating that moderate conduction excited via hierarchical and quantitative design can maximize the absorption capability. Furthermore, the proposed versatile methodology of surface assembly paves a new avenue to maximize beneficial conduction effect and manipulate microwave attenuation in MOFs derivatives.
The In Situ Optimization of Spinterface in Polymer Spin Valve by Electronic Phase Separated Oxides
Authors: Zhang Cheng , Ding Shuaishuai , Tian Yuan , Wang Jing , Chen Yunzhong , Zhao Tongyun , Hu Fengxia , Hu Wenping , Shen Baogen 
Published: June 2023

AbstractTailoring the interface between organic semiconductor (OSC) and ferromagnetic (FM) electrodes, that is, the spinterface, offers a promising way to manipulate and optimize the magnetoresistance (MR) ratio of the organic spin valve (OSV) devices. However, the non‐destructive in situ regulation method of spinterface is seldom reported, limiting its theoretical research and further application in organic spintronics. (La2/3Pr1/3)5/8Ca3/8MnO3 (LPCMO), a recently developed FM material, exhibits a strong electronic phase separation (EPS) property, and can be employed as an effective in situ spinterface adjuster. Herein, we fabricated a LPCMO‐based polymer spin valve with a vertical configuration of LPCMO/poly(3‐hexylthiophene‐2,5‐diyl) (P3HT)/Co, and emphasized the important role of LPCMO/P3HT spinterface in MR regulation. A unique competitive spin‐scattering mechanism generated by the EPS characteristics of LPCMO inside the polymer spin valve was discovered by abstracting the anomalous non‐monotonic MR value as a function of pre‐set magnetic field (Bpre) and temperature (T). Particularly, a record‐high MR ratio of 93% was achieved in polymer spin valves under optimal conditions. These findings highlight the importance of interdisciplinary research between organic spintronics and EPS oxides and offer a novel scenario for multi‐level storage via spinterface manipulation.
Roles of N6‐methyladenosine epitranscriptome in non‐alcoholic fatty liver disease and hepatocellular carcinoma
Authors: Chen Yuyan , Zhu Zhengyi , Zhang Lu , Wang Jinglin , Ren Haozhen 
Published: June 2023

AbstractNon‐alcoholic fatty liver disease (NAFLD) is a typical chronic liver disease connected to a high risk of developing hepatocellular carcinoma (HCC). The development of NAFLD and HCC has been associated with changes in epigenetics, such as histone modifications and micro RNA (miRNA)‐mediated processes. Recently, in the realm of epitranscriptomics, RNA alterations have become important regulators. N6‐methyladenosine (m6A) is the most common and crucial alteration for controlling mRNA stability, splicing, and translation. It is particularly important for controlling liver disease progression and hepatic function. This review aims to conclude recent research on the functions of m6A epitranscriptome in the molecular mechanisms behind NAFLD and HCC development, with special attention to the effects of m6A alteration on how HCC develops and its possible roles in the progression of NAFLD to HCC. Additionally, the review discusses the possible effects of m6A alteration on the treatment and diagnostic of NAFLD and HCC. It is crucial to remember that m6A modification is a reversible action controlled via the coordinated functions of the proteins that write and delete, enabling quick adaptability to environmental changes. The review also discusses m6A‐binding proteins' function in mRNA alternative splicing, translation, and degradation and their ability to modulate mRNA stability and processing. Understanding RNA modification regulation and its part in the emergence of HCC and NAFLD may provide new avenues for diagnosing and treating these diseases.
Genomic approaches to enhance adaptive plasticity to cope with soil constraints amidst climate change in wheat
Authors: Bhoite Roopali , Han Yong , Chaitanya Alamuru Krishna , Varshney Rajeev K. , Sharma Darshan Lal 
Published: June 2023

AbstractClimate change is varying the availability of resources, soil physicochemical properties, and rainfall events, which collectively determines soil physical and chemical properties. Soil constraints—acidity (pH < 6), salinity (pH ≤ 8.5), sodicity, and dispersion (pH > 8.5)—are major causes of wheat yield loss in arid and semiarid cropping systems. To cope with changing environments, plants employ adaptive strategies such as phenotypic plasticity, a key multifaceted trait, to promote shifts in phenotypes. Adaptive strategies for constrained soils are complex, determined by key functional traits and genotype × environment × management interactions. The understanding of the molecular basis of stress tolerance is particularly challenging for plasticity traits. Advances in sequencing and high‐throughput genomics technologies have identified functional alleles in gene‐rich regions, haplotypes, candidate genes, mechanisms, and in silico gene expression profiles at various growth developmental stages. Our review focuses on favorable alleles for enhanced gene expression, quantitative trait loci, and epigenetic regulation of plant responses to soil constraints, including heavy metal stress and nutrient limitations. A strategy is then described for quantitative traits in wheat by investigating significant alleles and functional characterization of variants, followed by gene validation using advanced genomic tools, and marker development for molecular breeding and genome editing. Moreover, the review highlights the progress of gene editing in wheat, multiplex gene editing, and novel alleles for smart control of gene expression. Application of these advanced genomic technologies to enhance plasticity traits along with soil management practices will be an effective tool to build yield, stability, and sustainability on constrained soils in the face of climate change.
3Dpolymer composite filament development from post‐consumer polypropylene and disposable chopstick fillers
Authors: Tan Yee Ai , Chan Ming Yeng , Koay Seong Chun , Ong Thai Kiat 
Published: June 2023

AbstractThis study focused on the development of three‐dimensional (3D) polymer composite filament made of disposable chopstick (DC) and post‐consumer polypropylene (PPP). The PPP/DC composite parts were printed via fused filament fabrication (FFF) process. The effect of the printing temperature and different DC fiber content on the properties of the 3D printed parts were investigated. The printing temperature of 200–220°C was suitable for these filaments because the printing temperature did not show any thermal degradation, as proven by thermogravimetric analysis. Furthermore, the thermal stability of the 3D filament increased with DC content. The chemical modification with sodium hydroxide (NaOH) was carried out on DC to remove the unwanted organic components by showing changes in peak intensity in the Fourier transform infrared analysis. Moreover, the melt flow index of the composite filaments decreased with increasing of the DC content and caused the composites' viscosity increased. The results show that the optimum printing temperature of 210°C would reduce the warping and gave better tensile properties to the 3D printed parts. Nevertheless, the tensile strength and elongation at break of the 3D printed PPP/DC parts reduced as the DC content increased because the presence of some air gap and fiber pull out on the fracture surface of 3D printed parts, which are in line with the results observed from scanning electron microscopy. However, the tensile strength and elongation at break percentage of all 3D printed PPP/DC composite parts were higher in comparison with the 3D parts printed by commercial wood plastic composite filament.
Utilization and performance evaluation of mixed matrix membranes for the treatment of produced water: A review
Authors: Razak Norhidayu Abd , Nasir Rizwan , Azmi Nurulhuda , Mukhtar Hilmi , Mohsim Dzeti Farhah , Mustafa Muhammad Raza Ul 
Published: June 2023

AbstractProduced water (PW) has been generated in a huge amount representing the largest volume waste stream. Membrane technology has found a leading ability in treating PW due to its significant advantages, such as lower cost, easy installation, and being environmentally friendly. Mixed matrix membranes (MMMs) have received significant research interest due to their flexibility, multifunctionality enhances the membrane performance with increasing selectivity, permeability, robustness, mechanical strength, and resistance to fouling. This mini‐review paper identifies the utilization of different membranes for treating PW. It also gives a review of different types of MMMs with specific fillers for the application of PW treatment. Lastly, some methods to enhance the performance of mixed matrix membranes have been highlighted. The issues and challenges in membranes are also discussed.Practitioner Points
Mixed matrix membranes (MMMs) are a potential membrane type for PW treatment.
This mini‐review paper identifies the use of several membranes to treat PW. It also examined various types of MMMs containing specific fillers for the application of PW treatment.
Methods for improving the performance of mixed matrix membranes have been highlighted, including the use of novel materials, surface modification, and cross‐linking.
The issues and challenges in membranes are also discussed.
Recent advances of AIE‐active materials for orthotopic tumor phototheranostics
Authors: Sun Yan , Tan Yonghong , Yan Dingyuan , Gui Yixiong , Luo Wenshuai , Zhu Dongxia , Wang Dong , Tang Ben Zhong 
Published: June 2023

AbstractCancer ranks as a leading threat to human life and health. Compared to conventional cancer treatments, phototheranostics shares the advantages of integrated diagnosis and therapy, outstanding therapeutic performance and good controllability. Amid diverse phototheranostic agents, small organic luminogens with aggregation‐induced emission (AIEgen) tendency show predominant advantages in terms of superior photostability, large Stokes shifts, and boosted theranostic capacity as aggregates. In the past two decades, AIE‐active materials have demonstrated formidable applications in disease theranostics, especially for tumors. This review mainly highlights the recent advances of orthotopic tumor phototheranostics mediated by AIEgens with a classification of different organs. Additionally, a brief discussion of current bottlenecks and future directions is outlined. We believe this review can deepen the understanding and spur more innovations on tumor theranostics by employing AIEgens.This article is categorized under:
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging