bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anopheles vector distribution and malaria transmission dynamics in Gbêkê region, central Côte d’Ivoire
Authors: Koffi Alphonsine A. , Camara Soromane , Ahoua Alou Ludovic P. , Oumbouke Welbeck A. , Wolie Rosine Z. , Tia Innocent Z. , Sternberg Eleanore D. , Yapo Florent H. A. , Koffi Fernand M. , Assi Serge B. , Cook Jackie , Thomas Matthew B. , N’Guessan Raphael 
Published: June 2023

Abstract
Background
A better understanding of vector distribution and malaria transmission dynamics at a local scale is essential for implementing and evaluating effectiveness of vector control strategies. Through the data gathered in the framework of a cluster randomized controlled trial (CRT) evaluating the In2Care (Wageningen, Netherlands) Eave Tubes strategy, the distribution of the Anopheles vector, their biting behaviour and malaria transmission dynamics were investigated in Gbêkê region, central Côte d’Ivoire.

Methods
From May 2017 to April 2019, adult mosquitoes were collected monthly using human landing catches (HLC) in twenty villages in Gbêkê region. Mosquito species wereidentified morphologically. Monthly entomological inoculation rates (EIR) were estimated by combining the HLC data with mosquito sporozoite infection rates measured in a subset of Anopheles vectors using PCR. Finally, biting rate and EIR fluctuations were fit to local rainfall data to investigate the seasonal determinants of mosquito abundance and malaria transmission in this region.

Results
Overall, Anopheles gambiae, Anopheles funestus, and Anopheles nili were the three vector complexes found infected in the Gbêkê region, but there was a variation in Anopheles vector composition between villages. Anopheles gambiae was the predominant malaria vector responsible for 84.8% of Plasmodium parasite transmission in the area. An unprotected individual living in Gbêkê region received an average of 260 [222–298], 43.5 [35.8–51.29] and 3.02 [1.96–4] infected bites per year from An. gambiae, An. funestus and An. nili, respectively. Vector abundance and malaria transmission dynamics varied significantly between seasons and the highest biting rate and EIRs occurred in the months of heavy rainfall. However, mosquitoes infected with malaria parasites remained present in the dry season, despite the low density of mosquito populations.

Conclusion
These results demonstrate that the intensity of malaria transmission is extremely high in Gbêkê region, especially during the rainy season. The study highlights the risk factors of transmission that could negatively impact current interventions that target indoor control, as well as the urgent need for additional vector control tools to target the population of malaria vectors in Gbêkê region and reduce the burden of the disease.
Oral intake of titanium dioxide nanoparticles affect the course and prognosis of ulcerative colitis in mice: involvement of the ROS-TXNIP-NLRP3 inflammasome pathway
Authors: Duan Shumin , Wang Hongbo , Gao Yanjun , Wang Xiang , Lyu Lizhi , Wang Yun 
Published: June 2023

Abstract
Background
Titanium dioxide (TiO2), no matter in nanoscale or micron sizes, has been widely used in food industry as additives for decades. Given the potential impact of TiO2 on the gastrointestinal epithelial and parenchymal cells, including goblet cells, the public consumers may suffer the risk of diseases caused by its widespread dissemination in food products. We therefore set out to investigate the impact of TiO2 NPs on the course and prognosis of ulcerative colitis by oral gavaging TiO2 NPs at the doses levels of 0, 30, 100, and 300 mg/kg during the induction (7 days, from day 1 to day 7) and recovery (10 days, from day 8 to day 17) phases of colitis in mice.

Results
The ulcerative colitis (UC) disease model was established by administrating of 2.5% dextran sulfate sodium (DSS) solution. Our results show that TiO2 NPs significantly enhanced the severity of DSS-induced colitis, decreased the body weight, increased the disease activity index (DAI) and colonic mucosa damage index (CMDI) scores, shortened the colonic length, increased the inflammatory infiltration in the colon. The most significant changes occurred in the low dose (30 mg/kg) group of TiO2 NPs exposure during the development phase of UC and the high dose (300 mg/kg) group of TiO2 NPs during UC self-healing phase. Increased reactive oxygen species (ROS) level and upregulation of anti-oxidant enzymes including total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-PX) and catalase (CAT), demonstrate that the TiO2 NP exposure has triggered oxidative stress in mice. Moreover, the upregulation of caspase-1 mRNA and increased expression of thioredoxin interacting protein (TXNIP) further demonstrate the involvement of the ROS-TXNIP-NLR family pyrin domain containing 3 (NLRP3) inflammasome pathway in aggravating the development of UC.

Conclusion
Oral intake of TiO2 NPs could affect the course of acute colitis in exacerbating the development of UC, prolonging the UC course and inhibiting UC recovery.

Graphical Abstract
ALOX5AP suppresses osteosarcoma progression via Wnt/β-catenin/EMT pathway and associates with clinical prognosis and immune infiltration
Authors: Han Guo-Dong , Dai Jian , Hui Hong-Xia , Zhu Jing 
Published: June 2023

AbstractOsteosarcoma (OS) is one of the most common malignant neoplasms in children and adolescents. Immune infiltration into the microenvironment of the tumor has a positive correlation with overall survival in patients with OS. The purpose of this study was to search for potential diagnostic markers that are involved in immune cell infiltration for OS. Patients with OS who acquired metastases within 5 years (n = 34) were compared to patients who did not develop metastases within 5 years (n = 19). Differentially expressed genes (DEGs) were tested for in both patient groups. To discover possible biomarkers, the LASSO regression model and the SVM–RFE analysis were both carried out. With the assistance of CIBERSORT, the compositional patterns of the 22 different types of immune cell fraction in OS were estimated. In this research, a total of 33 DEGs were obtained: 33 genes were significantly downregulated. Moreover, we identified six critical genes, including ALOX5AP, HLA-DOA, HLA-DMA, HLA-DRB4, HCLS1 and LOC647450. ROC assays confirmed their diagnostic value with AUC > 0.7. In addition, we found that the six critical genes were associated with immune infiltration. Then, we confirmed the expression of ALOX5AP was distinctly decreased in OS specimens and cell lines. High expression of ALOX5AP predicted an advanced clinical stage and overall survival of OS patients. Functionally, we found that overexpression of ALOX5AP distinctly suppressed the proliferation, migration, invasion and EMT via modulating Wnt/β‐catenin signaling. Overall, we found that ALOX5AP overexpression inhibits OS development via regulation of Wnt/β‐catenin signaling pathways, suggesting ALOX5AP as a novel molecular biomarker for enhanced therapy of OS.
From Xiaoke to diabetes mellitus: a review of the research progress in traditional Chinese medicine for diabetes mellitus treatment
Authors: Meng Xianglong , Liu Xiaoqin , Tan Jiaying , Sheng Qi , Zhang Dingbang , Li Bin , Zhang Jia , Zhang Fayun , Chen Hongzhou , Cui Tao , Li Minghao , Zhang Shuosheng 
Published: June 2023

AbstractDiabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia resulting from insulin secretion defects or insulin resistance. The global incidence of DM has been gradually increasing due to improvements in living standards and changes in dietary habits, making it a major non-communicable disease that poses a significant threat to human health and life. The pathogenesis of DM remains incompletely understood till now, and current pharmacotherapeutic interventions are largely inadequate, resulting in relapses and severe adverse reactions. Although DM is not explicitly mentioned in traditional Chinese medicine (TCM) theory and clinical practice, it is often classified as “Xiaoke” due to similarities in etiology, pathogenesis, and symptoms. With its overall regulation, multiple targets, and personalized medication approach, TCM treatment can effectively alleviate the clinical manifestations of DM and prevent or treat its complications. Furthermore, TCM exhibits desirable therapeutic effects with minimal side effects and a favorable safety profile. This paper provides a comprehensive comparison and contrast of Xiaoke and DM by examining the involvement of TCM in their etiology, pathogenesis, treatment guidelines, and other relevant aspects based on classical literature and research reports. The current TCM experimental research on the treatment of DM by lowering blood glucose levels also be generalized. This innovative focus not only illuminates the role of TCM in DM treatment, but also underscores the potential of TCM in DM management.
Dietary intervention for children and adolescents with familial hypercholesterolaemia
Authors: Capra Maria Elena , Biasucci Giacomo , Crivellaro Elisa , Banderali Giuseppe , Pederiva Cristina 
Published: June 2023

AbstractFamilial hypercholesterolaemia (FH) is a frequent genetic disorder characterised by high plasma levels of total and LDL-cholesterol and premature atherosclerosis. If left untreated, affected subjects have a high risk of cardiovascular disease, as they are exposed to very high levels of LDL-cholesterol from birth. Healthy dietary habits and lifestyle are the first treatment option and, if started from childhood, represent a milestone in the prevention of atherosclerotic disease, both as a starting point and in combination with drug therapy. In this work, based on the main consensus documents available so far, we have evaluated the most up-to-date indications of the dietetic-nutritional intervention for the treatment of FH, delving into the peculiar aspects of the diet of the child/adolescent affected by FH. After an analysis of the macro- and micronutrients and the most common dietary patterns currently recommended, we highlighted some practical aspects, some frequent errors and some risks we could fall into when dealing with paediatric nutritional treatment. In conclusion, the dietary intervention for the child/adolescent with FH is a complex task, that should be individualised and tailored taking into account, first of all, the nutritional adequacy for growth and development, but also the multiple aspects linked to the child/adolescent's age, tastes and preferences, the family they belong to, the socio-economic context and the Country they live in.
Screening and treating problematic substance use among patients in psychiatry – obstacles and solutions
Authors: Petersén Elisabeth , Berman Anne H 
Published: June 2023

Abstract
Objective
In Sweden, national guidelines recommend that all staff in the healthcare system systematically screen patients for alcohol use and illicit substance use. Where hazardous use is identified, it should be addressed as soon as possible, preferably through brief interventions (BI). Results from a previous national survey showed that most clinic directors stated that they had clear guidelines for screening alcohol use and illicit substance use, but that fewer staff than expected used screening in their work. This study aims to identify obstacles and solutions to screening and brief intervention, based on survey respondents’ free-text responses to open-ended questions.

Results
A qualitative content analysis yielded four codes: guidelines, continuing education, cooperation and resources. The codes indicated that staff would need (a) clearer routines in order to optimize compliance with the national guidelines; (b) more knowledge about how to treat patients with problematic substance use; (c) better cooperation between addiction care and psychiatry; and (d) increased resources to improve routines at their own clinic. We conclude that increased resources could contribute to better routines and cooperation, and provide increased opportunities for continuing education. This could increase guideline compliance and increase healthy behavior changes among patients in psychiatry with problematic substance use.
Two-stage hybrid genetic algorithm for robot cloud service selection
Authors: Yin Lei , Liu Jin , Fang Yadong , Gao Ming , Li Ming , Zhou Fengyu 
Published: June 2023

AbstractRobot cloud service platform is a combination of cloud computing and robotics, providing intelligent cloud services for many robots. However, to select a cloud service that satisfys the robot’s requirements from the massive services with different QoS indicator in the cloud platform is an NP hard problem. In this paper, based on the cost model between the cloud platform, cloud services and cloud service robotics, we propose a two-stage service selection strategy, namely, candidate services selection stage according to the specific QoS requirements of service robots and final cost optimization stage. Additionally, with respect to optimizing the final cost for the model, we propose a Dynamic Vector Hybrid Genetic Algorithm (DVHGA) that is integrated with local and global search process as well as a three-phase parameter updating policy. Specifically, inspired by momentum optimization in deep learning, dynamic vector is integrated with DVHGA to modify the weights of QoS and ensure the reasonable allocation of resources. Moreover, we suggest a linear evaluation method for the service robots and the cloud platform concerning time and final cost at the same time, which could be expected to be used in the real application environment. Finally, the empirical results demonstrate that the proposed DVHGA outperforms other benchmark algorithms, i.e., DABC, ESWOA, GA, PGA and GA-PSO, in convergence rate, total final cost and evaluation score.
HGAT: smart contract vulnerability detection method based on hierarchical graph attention network
Authors: Ma Chuang , Liu Shuaiwu , Xu Guangxia 
Published: June 2023

AbstractWith the widespread use of blockchain, more and more smart contracts are being deployed, and their internal logic is getting more and more sophisticated. Due to the large false positive rate and low detection accuracy of most current detection methods, which heavily rely on already established detection criteria, certain smart contracts additionally call for human secondary detection, resulting in low detection efficiency. In this study, we propose HGAT, a hierarchical graph attention network-based detection model, in order to address the aforementioned issues as well as the shortcomings of current smart contract vulnerability detection approaches. First, using Abstract Syntax Tree (AST) and Control Flow Graph, the functions in the smart contract are abstracted into code graphs (CFG). Then abstract each node in the code subgraph, extract the node features, utilize the graph attention mechanism GAT, splice the obtained vectors to form the features of each line of statements and use these features to detect smart contracts. To create test data and assess HGAT, we leverage the open-source smart contract vulnerability sample dataset. The findings of the experiment indicate that this method can identify smart contract vulnerabilities more quickly and precisely than other detection techniques.
Detection and genetic characterization of enteric viruses in diarrhoea outbreaks from swine farms in Spain
Authors: Puente Héctor , Arguello Héctor , Cortey Martí , Gómez-García Manuel , Mencía-Ares Oscar , Pérez-Perez Lucía , Díaz Ivan , Carvajal Ana 
Published: June 2023

Abstract
Background
The aim of this work was to study the prevalence and distribution of Porcine astrovirus (PAstV), Porcine kobuvirus (PKoV), Porcine torovirus (PToV), Mammalian orthoreovirus (MRV) and Porcine mastadenovirus (PAdV) as well as their association with widely recognized virus that cause diarrhoea in swine such as coronavirus (CoVs) and rotavirus (RVs) in diarrhoea outbreaks from Spanish swine farms. Furthermore, a selection of the viral strains was genetically characterized.

Results
PAstV, PKoV, PToV, MRV and PAdV were frequently detected. Particularly, PAstV and PKoV were detected in almost 50% and 30% of the investigated farms, respectively, with an age-dependent distribution; PAstV was mainly detected in postweaning and fattening pigs, while PKoV was more frequent in sucking piglets. Viral co-infections were detected in almost half of the outbreaks, combining CoVs, RVs and the viruses studied, with a maximum of 5 different viral species reported in three investigated farms. Using a next generation sequencing approach, we obtained a total of 24 ARN viral genomes (> 90% genome sequence), characterizing for first time the full genome of circulating strains of PAstV2, PAstV4, PAstV5 and PToV on Spanish farms. Phylogenetic analyses showed that PAstV, PKoV and PToV from Spanish swine farms clustered together with isolates of the same viral species from neighboring pig producing countries.

Conclusions
Although further studies to evaluate the role of these enteric viruses in diarrhoea outbreaks are required, their wide distribution and frequent association in co-infections cannot be disregard. Hence, their inclusion into routine diagnostic panels for diarrhoea in swine should be considered.
Complementary and Alternative Medicine Use in Patients With Cancer and Immigration Background
Authors: Wu Alex , Wu Yunhong , Natarajan Vijaya , Singh Prabhsimranjot , Cheema Waseem , Hossain Rukhsana , Liu Christine , Mejia Yocasta , Oo Myoe Htet Htet , Valenzano Bina , Xu Yiqing 
Published: June 2023

PURPOSE Studies have shown that patients with cancer are more likely to use complementary and alternative medicine (CAM) than noncancer patients for symptom relief and hope. We aimed to evaluate factors of race, ethnic groups, and immigration status in attitude of patients with cancer in seeking out CAM. PATIENTS AND METHODS This is a prospective questionnaire study where information on demographics, cancer information, race/ethnicity, immigration duration, and psychosocial factors was correlated with the CAM use in a community cancer center located in the borough of Brooklyn, at New York City. RESULTS Among 658 patients, the prevalence of CAM use was 66.11%. CAM use was 71.98% in females and 54.34% in males ( P = .113 × 10−4). Patients of African descent had higher CAM use (72.73%) than the White patients (63.53%; P = .0371). There was no difference of CAM use between the US born (68.77%) and the immigrants (63.98%, P = .199) as a whole; however, comparing with the US born (66.50%), Asian-born immigrants had lower CAM use (53.77%, P = .0161), whereas Latin-American born had a numerical trend toward higher CAM use (74.83%, P = .0608). The number of years of living in the United States was not associated with more CAM use. Prayer and spirituality was the most common CAM subtype used (25.91%). There was no difference in CAM use in the respective non-White ethnic groups whether they were US born or non-US born. CONCLUSION In this cohort of patients with cancer enriched with immigration background, CAM use was the highest in African American patients. The use of CAM in the non-White patients was associated with their ethnic background, regardless whether they were US born or not. Cultural roots appeared to be a strong influencing factor for the usage of CAM.
Variant Tyr 394Ser in the GCM2 Gene Is Rare in a Cohort of Ashkenazi Jews With Primary Hyperparathyroidism
Authors: Tolkin Lior , Klein Vanessa , Frankel Meir , Altarescu Gheona , Beeri Rachel , Munter Gabriel 
Published: June 2023

Abstract

Context
Various genes have been associated with familial and sporadic primary hyperparathyroidism (PHPT), including activating mutations of the glial cells missing transcription factor 2 (GCM2) gene.

Objective
The aim of this study was to assess the prevalence of the GCM2 p.Tyr394Ser variant in the Jerusalem Ashkenazi Jewish (AJ) population with PHPT, and to conclude whether routine genetic testing is justified.

Methods
The blood of 40 self-reported AJ patients with PHPT and 200 AJ controls was tested for the GCM2 p.Tyr394Ser variant. Demographic and medical information was extracted from the patients’ charts and evaluated accordingly.

Results
Two (5%) PHPT patients and 3 (1.5%) controls were heterozygotes for the tested variant. Our patients were mostly (87.5%) sporadic cases. One of the heterozygote patients had familial PHPT; the other had 2 parathyroid adenomas, and the levels of his blood and urinary calcium were extremely high.

Conclusion
Our results suggest that in AJ patients with sporadic, single-gland PHPT, the likelihood of the tested variant is low and genetic testing should be limited to those with familial PHPT or multiglandular disease.
Between Shine and Porosity
Authors: Musser Amber Jamilla 
Published: June 2023

AbstractThis article performs a close reading of an advertisement of Fenty Beauty's Body Lava featuring Rihanna in order to tease apart the imbrications of celebrity, sexuality, blackness, and labor by using an analytic of sweat. Since sweat is secreted by the body, this article is particularly interested in its relationship to enfleshment and what it tells us about the material aspects of black ecologies. Working through how and where sweat surfaces and doesn't in this image of Rihanna offers a way to unpack the utility of sweat as an analytic. Sweat offers insight into why shine connotes both work and sex while also giving us a way move beyond shine and toward sweating and the intimacies offered by porosity.
From Financialization to Derivative Fascisms
Authors: Haiven Max 
Published: June 2023

Abstract
The last forty years of financialization have laid the groundwork for a resurgence of fascist cultural politics. This article expands Hito Steyerl's notion of derivative fascism by placing it in dialogue with Enzo Traverso's theory of postfascism and Randy Martin's exploration of the sociality of the derivative. Such a conjunction allows us to gain a better understanding of how financialization encourages the transformation of social subjects in ways that lend themselves to fascistic dispositions. Far-right authoritarian actors and movements find sympathy and adherents among people who are expected to become competitive, creative, and self-interested risk takers but find themselves in a world where, for the vast majority, risks are proliferating and unmanageable. This approach can offer a useful supplement to other critical theorizations of the recent resurgence of fascist cultural politics that focus on race, gender, and the longer lineages of reactionary thought. In the first place, it helps us account for the particular financialized context for these cultural politics. Second, it helps us account for how they thrive on highly constrained and speculative forms of decentralized creative agency, entrepreneurship, and conviviality.