bluuebunny/crossref_metadata_2025_split huggingface dataset:
Covalent Organic Framework with Multi‐Cationic Molecular Chains for Gate Mechanism Controlled Superionic Conduction in All‐Solid‐State Batteries
Authors: Gong Wei , Ouyang Yuan , Guo Sijia , Xiao Yingbo , Zeng Qinghan , Li Dixiong , Xie Yufeng , Zhang Qi , Huang Shaoming 
Published: March 2023

AbstractAlthough solid‐state batteries (SSBs) are high potential in achieving better safety and higher energy density, current solid‐state electrolytes (SSEs) cannot fully satisfy the complicated requirements of SSBs. Herein, a covalent organic framework (COF) with multi‐cationic molecular chains (COF‐MCMC) was developed as an efficient SSE. The MCMCs chemically anchored on COF channels were generated by nano‐confined copolymerization of cationic ionic liquid monomers, which can function as Li+ selective gates. The coulombic interaction between MCMCs and anions leads to easier dissociation of Li+ from coordinated states, and thus Li+ transport is accelerated. While the movement of anions is restrained due to the charge interaction, resulting in a high Li+ conductivity of 4.9×10−4 S cm−1 and Li+ transference number of 0.71 at 30 °C. The SSBs with COF‐MCMC demonstrate an excellent specific energy density of 403.4 Wh kg−1 with high cathode loading and limited Li metal source.
Aggregation‐Induced Emission by Molecular Design: A Route to High‐Performance Light‐Emitting Electrochemical Cells
Authors: Tang Shi , Wang Zhi , Xu Yanzi , Ma Huili , Wang Jia , Larsen Christian , Dang Dongfeng , Wang Ergang , Edman Ludvig 
Published: March 2023

AbstractThe emission efficiency of organic semiconductors (OSCs) often suffers from aggregation caused quenching (ACQ). An elegant solution is aggregation‐induced emission (AIE), which constitutes the design of the OSC so that its morphology inhibits quenching π–π interactions and non‐radiative motional deactivation. The light‐emitting electrochemical cell (LEC) can be sustainably fabricated, but its function depends on motion of bulky ions in proximity of the OSC. It is therefore questionable whether the AIE morphology can be retained during LEC operation. Here, we synthesize two structurally similar OSCs, which are distinguished by that1features ACQ while2delivers AIE. Interestingly, we find that the AIE‐LEC significantly outperforms the ACQ‐LEC. We rationalize our finding by showing that the AIE morphology remains intact during LEC operation, and that it can feature appropriately sized free‐volume voids for facile ion transport and suppressed non‐radiative excitonic deactivation.
Phenazine‐based Compound Realizing Separate Hydrogen and Oxygen Production in Electrolytic Water Splitting
Authors: Wu Kangxi , Li Haoze , Liang Shuaika , Ma Yuanyuan , Yang Jianping 
Published: March 2023

AbstractElectrocatalytic water splitting powered by renewable energy is a sustainable approach for hydrogen production. However, conventional water electrolysis may suffer from gas mixing, and the different kinetics between hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) will limit the direct use of unstable renewable energies, leading to increased cost of H2 production. Herein, a novel phenazine‐based compound is synthesized to develop the solid‐state redox mediator associated water splititng process, and thus decoupling the H2 and O2 production in acid solution without the use of membrane. Excitingly, this organic redox mediator exhibits high specific capacity (290 mAh g−1 at 0.5 A g−1), excellent rate performance (186 mAh g−1 at 30 A g−1) and long cycle life (3000 cycles) due to its π‐conjugated aromatic structure and the fast kinetics of H+ storage/release process. Furthermore, a membrane‐free decoupled water electrolysis architecture driven by solar energy is achieved, demonstrating high‐purity H2 production at different times.
Autoantibodies Recognizing Specificity Protein 4 Co‐occur With Anti–Transcription Intermediary Factor 1 and Are Associated With Distinct Clinical Features and Immunogenetic Risk Factors in Juvenile Myositis
Authors: Sherman Matthew A. , Pak Katherine , Pinal‐Fernandez Iago , Flegel Willy A. , Targoff Ira N. , Miller Frederick W. , Rider Lisa G. , Mammen Andrew L. ,   for the Childhood Myositis Heterogeneity Collaborative Study Group
Published: March 2023

ObjectiveAutoantibodies recognizing specificity protein 4 (Sp4) were recently discovered in adults with idiopathic inflammatory myopathies (IIM). Anti‐Sp4 autoantibodies co‐occurred in patients with anti–transcription intermediary factor 1 (anti‐TIF1) autoantibody‐positive dermatomyositis (DM) and were associated with a reduced risk of cancer. In the present study, the prevalence and clinical features associated with anti‐Sp4 autoantibodies in juvenile‐onset IIM were investigated.MethodsSerum samples from 336 patients with juvenile myositis in a cross‐sectional cohort and 91 healthy controls were screened for anti‐Sp4 autoantibodies using enzyme‐linked immunosorbent assay. Clinical characteristics, outcomes, and HLA alleles of those with and those without anti‐Sp4 autoantibodies were compared.ResultsAnti‐Sp4 autoantibodies were present in 23 patients (7%) with juvenile myositis and were not present in any of the controls. Anti‐Sp4 autoantibodies were found among each clinical myositis subgroup. The frequency of TIF1 autoantibody positivity was significantly higher among those with anti‐Sp4 autoantibodies (21 [91%] versus 92 [30%], P < 0.001). In the anti‐TIF1 autoantibody–positive subgroup, Raynaud's phenomenon (8 [38%] versus 2 [2%], P < 0.001) was more common and peak aspartate aminotransferase was significantly lower in those with anti‐Sp4 autoantibodies. None of the patients with anti‐Sp4 autoantibodies required a wheelchair. Among White patients, DQA1*04 and DRB1*08 were associated with anti‐Sp4 autoantibodies.ConclusionAnti‐Sp4 autoantibodies were found in patients with juvenile‐onset IIM, predominantly those with coexisting anti‐TIF1 autoantibodies. Patients with anti‐Sp4 autoantibodies represent a phenotypic subset of anti‐TIF1 autoantibody–positive myositis characterized by frequent Raynaud's phenomenon and less pronounced muscle involvement, similar to adults with these autoantibodies. Novel immunogenetic risk factors for White patients with IIM were identified among juveniles with anti‐Sp4 autoantibodies.
Socioeconomic status and students' science self‐efficacy
Authors: Tan Cheng Yong , Gao Lin , Hong Xiaoou , Song Qiongjiang 
Published: March 2023

AbstractThe present study ascertains the relationship between socioeconomic status (SES) and students' science self‐efficacy using data involving 509,182 15‐year‐old students and 17,678 school principals in 69 countries/regions who participated in the Programme for International Student Assessment (PISA) 2015. Hierarchical linear modelling results show that, after controlling for science teachers' instructional practices (science class disciplinary climate, inquiry‐based instruction, teachers' support, direct instruction, provision of feedback, instructional adaptation), school science resources and various student variables (gender, grade levels, type of school programme), SES was related to students' science self‐efficacy in the majority of countries/regions (62–68 countries/regions, depending on the SES indicators used). Specifically, SES was related to students' science self‐efficacy in a larger number of countries/regions when it was measured using home cultural resources, home educational resources or a composite indicator (economic, social and cultural status) than when it was measured using parental education levels or occupational status. In contrast, students' science self‐efficacy was unrelated to the science teachers' instructional practices examined (except inquiry‐based instruction) in most of the countries/regions. These results expand our understanding of students' science self‐efficacy, as a type of learning motivation, from being a largely psychological attribute to one that is also influenced by social origins such as family SES. They imply that SES may have a larger influence on student achievement than we may have assumed if we include the indirect influence of SES on student achievement via students' self‐efficacy.
FEM education in undergraduate studies: Industry‐informed research
Authors: Perez‐Santiago Rogelio , Campos Esmeralda 
Published: March 2023

AbstractRecent mechanical engineering graduates are expected to utilize Finite Element Analysis (FEA) in structural and machine design activities. However, after decades of implementation in engineering schools, the Finite Element Method (FEM) still challenges instructors and course designers. To align learning outcomes with industrial requirements, this article analyzes the opinions of Mexican industrial and academic experts about four important aspects of FEM education. The results suggest that specialists agree on the importance of including a mixture of theoretical and applied topics in the syllabus but prefer practical skills over fundamental concepts. Besides learning from defeaturing to postprocessing a model, engineering students must know how to plan, verify, and validate their finite element studies. Experts expect early design engineers to be proficient with Computer‐Aided Design (CAD) and have relevant mathematical and programming skills. Instead of using specialized software, students' first exposure to FEM may be based on FEA tools embedded in CAD systems. Also, academic and industrial respondents request the incorporation of modal, thermal and nonlinear analysis procedures in the course timetable. Finally, the statistical analysis shows that the two types of respondents share one common vision about the importance of the aspects under study. The findings from this work are useful for the design of FEM‐related coursework and can be used to guide course instructors about the right balance of theory and practice, overall course contents, and the selection of the software utilized for the practical part of the program.
Comparison of efficacies of haploidentical transplantation and matched sibling donor transplantation in treating T‐cell lymphoblastic lymphoma
Authors: Wei Ruowen , Fang Jun , Shi Wei , Lu Xuan , Wu Yingying , Jiang Shan , Zhang Ao , Liao Shanshan , Qin Chunxia , Cui Guohui , Xia Linghui 
Published: March 2023

AbstractObjectiveTo investigate the differences in efficacy and safety between haploidentical donor hematopoietic stem cell transplantation (HID‐HSCT) and matched sibling donor HSCT (MSD‐HSCT) in patients with T‐cell lymphoblastic lymphoma (T‐LBL).MethodsIn this retrospective analysis, we enrolled 38 patients who had undergone allogeneic HSCT at our institution between 2013 and 2021. The study participants included 28 patients who underwent HID‐HSCT and 10 patients who underwent MSD‐HSCT. We compared the patient characteristics and treatment effectiveness and safety between the two groups and evaluated potential prognostic variables for patients with T‐LBL.ResultsThe median follow‐up durations in the HID‐HSCT and MSD‐HSCT groups were 23.5 (range: 4–111) and 28.5 (range: 13–56) months, respectively. All patients showed full‐donor chimerism after hematopoietic stem cell transplantation (HSCT). Except for two patients in the HID‐HSCT cohort who developed poor graft function, all patients showed neutrophil and platelet engraftments after HSCT. The cumulative incidences of grades III–IV acute graft‐versus‐host disease were 37.5% and 28.57% in the HID‐HSCT and MSD‐HSCT groups, respectively (p = 0.84). The cumulative incidences of limited (34.13% vs. 28.57%, p = 0.82) and extensive (31.22% vs. 37.50%, p = 0.53) chronic graft‐versus‐host disease did not differ between the two cohorts. In the HID‐HSCT and MSD‐HSCT cohorts, the estimated 2‐year overall survival rates were 70.3% (95% confidence interval [CI]: 54.9%–90.0%) and 56.2% (95% CI: 31.6%–100%), respectively (p = 1.00), and the estimated 2‐year progression‐free survival (PFS) rates were 48.5% (95% CI: 32.8%–71.6%) and 48.0% (95% CI: 24.6%–93.8%), respectively (p = 0.94). Furthermore, the Cox proportional‐hazards model showed that a positive positron emission tomography/computed tomography (PET/CT) status before HSCT in patients who had completed chemotherapy was an independent risk factor for PFS in the multivariate analysis (p = 0.0367).ConclusionThis study showed that HID‐HSCT had comparable effectiveness and safety to MSD‐HSCT in treating T‐LBL. HID‐HSCT could serve as an alternate treatment option for T‐LBL in patients without an eligible identical donor. Achievement of the PET/CT‐negative status before HSCT may contribute to better survival.
Main causes of death in advanced biliary tract cancer
Authors: Kimura‐Seto Kana , Kojima Yasushi , Komori Shiori , Hisada Yuya , Otake Yuki , Yanai Yuka , Saito Akiko , Akazawa Naoki , Tanaka Yasuo , Yokoi Chizu , Yanase Mikio , Akiyama Junichi , Yamamoto Natsuyo , Yamada Kazuhiko 
Published: March 2023

AbstractBackgroundThere are no previous reports on the main causes of death in biliary tract cancer (BTC) patients. This study aimed to evaluate the main causes of death and survival rates in patients with BTC.MethodsWe retrospectively evaluated 143 patients who were diagnosed with unresectable BTC between August 2010 and March 2020. We classified the main causes of death based on laboratory data, imaging studies, and medical records. The main causes of death evaluated included liver failure, cholangitis, cachexia, other causes associated with tumor progression, and complications. We also analyzed survival rates for each main cause of death.ResultsAfter excluding patients who were lost to follow‐up, living patients, and patients who had no records of laboratory data within 30 days before the date of death, 108 patients were analyzed. The main cause of death was cholangitis in 33 (30.6%), cachexia in 22 (20.4%), liver failure in 10 (9.3%), other causes associated with tumor progression in 18 (16.7%), and complications in 25 (23.2%) patients. Median overall survival (OS) was 334.0 days in the chemotherapy group and 75.0 days in the best supportive care (BSC) group. Survival analyzed according to the main cause of death was significantly different between the chemotherapy and BSC groups; OS for cachexia, cholangitis, liver failure, other causes associated with tumor progression, and complications, respectively, were 453.0, 499.0, 567.0, 205.0, and 327.5 days (p = 0.003) in the chemotherapy group and 219.0, 69.0, 34.0, 93.0, and 56.0 days (p = 0.001) in the BSC group.ConclusionThe main causes of death in patients with advanced BTC are cholangitis, cachexia, liver failure, other causes associated with tumor progression, and complications. Other causes associated with tumor progression in the chemotherapy group, and liver failure in the BSC group as the main causes of death shortened the survival of BTC patients.
Phytochemical and Cytogenetic Study of Two Centaurea Species from Croatia: the Particular Case of Diploid and Tetraploid C. salonitana
Authors: Carev Ivana , Ruščić Mirko , Glumac Mateo , Politeo Olivera , Siljak‐Yakovlev Sonja 
Published: March 2023

AbstractNatural wild populations of C. rupestris and C. salonitana were studied to determine possible relationships between the volatile oil (VO) composition and ploidy level. The chemical composition of the volatile oil was investigated using the GC/MS technique. The predominant components of the VO of diploid and tetraploid C. salonitana were hexadecanoic acid and α‐linoleic acids, while in C. rupestris they were germacrene D and β‐caryophyllene in one population and heptacosane and germacrene D, in another. The nuclear DNA amounts (2 C DNA), determined by flow cytometry, were 3.54 pg for C. rupestris, 3.39 pg for the diploid and 6.79 pg for the tetraploid population of C. salonitana. Evidence that the degree of ploidy solely influences the chemical composition of the essential oil of C. salonitana was not found. The results presented are the first data to be reported on the DNA content of the studied Centaurea populations from Croatia, as well as on the chemical composition of C. salonitana volatile oil.
Influence of the Cobalt Active Site Neighbours in NiCo Nanocatalysts for Phosphine‐Assisted Silane Activation
Authors: Ropp Anthony , Carenco Sophie 
Published: March 2023

AbstractNiCo nanoparticles are active catalysts for a number of reactions, as an interesting alternative to noble metals. In particular, phosphine‐covered NiCo nanoparticles with a 1 : 1 metal ratio were found to be active at room temperature for Si−H bond activation. However, it was unclear which of the two metals was the active site and if the neighbouring atoms influenced the reaction efficiency. We designed nanoparticles with a nickel core and a limited amount of cobalt surface sites, just below or just above a monolayer amount, to investigate this question. We showed that the trend in catalytic activity is consistent with cobalt being the active site, and it shows a higher activity when its immediate neighbours are cobalt atoms. This was consistently observed with two phosphine ligands, PPh3 and PnBu3, while the first allowed a higher conversion rate than the second.
Highly Selective and Quantitative Point‐of‐Care Diagnostic Method for Adrenaline
Authors: Koppayithodi Sudeep , Jana Palash , Bandyopadhyay Subhajit 
Published: March 2023

AbstractAdrenaline, also known as epinephrine, is a neurotransmitter/hormone that is an important target in diagnostics. Development of an effective method for detecting it in the presence of other neurotransmitters is a challenging task. The electrochemical and fluorescent techniques commonly used have low selectivity in distinguishing among catecholamines. Herein, a small‐molecule organic probe with an activated furfural moiety is reported to exploit the nucleophilicity of epinephrine to generate a bright‐colored donor–acceptor Stenhouse adduct. Among nine common neurotransmitters or their analogues, only epinephrine was found to generate a unique colour change discernible with the naked eye, whereas the other ones remain unaffected. Under various in‐field detection conditions, including solution, droplet, and paper strip‐based detection, the colour change were also noticeable. The low detection limit of 1.37 nM and a limit of quantitation of 4.37 nM were achieved with simple UV/Vis methods in addition to the sub‐ppm level sensing under visual conditions with naked eyes. The probe could be used for practical colorimetric measurements as a point‐of‐care tool without any complex and expensive machinery, making this approach accessible to all. In addition, using a simple smartphone, the determination of epinephrine concentrations is possible by using machine‐learning techniques.
Detailed Thermal Evaluation of Brazed Plate Heat Exchanger Using Infrared Thermography
Authors: Will Torsten , Schnabel Lena , Köhler Jürgen 
Published: March 2023

AbstractInfrared thermography of brazed plate heat exchangers for evaporators and condensers recently was used to quantify maldistribution. With the knowledge of the secondary fluids heat transfer coefficient and a given secondary fluids distribution, the local heat transfer coefficient of the primary fluid (refrigerant) and its distribution to the channels can be calculated. A sensitivity analysis shows ± 10 % difference of the surface temperature to the wall center temperature at the expected ratios of heat transfer coefficients. The method is presented in this paper using an exemplary infrared picture.
Theoretical framework of sustainable value creation by companies. What do we know so far?
Authors: Zioło Magdalena , Bąk Iwona , Spoz Anna 
Published: March 2023

AbstractIn conditions of limited natural resources, growing social awareness, and ESG risk, sustainability and the pressure to be sustainable are gaining importance. Legislative requirements, good practices and recommendations as well as the stakeholders themselves expect from market participants, especially from the enterprise sector, that they will incorporate sustainability in their activities. Enterprises undertake adaptation activities towards sustainability by creating sustainable value based on their business models. The article aims to systematize the state of knowledge on how companies create sustainable value. Research results in this area are dispersed, and more studies discussing this topic comprehensively are needed. The article fills the gap in research by reviewing the existing studies on creating sustainable value. The analysis of publications was based on the academic databases of Elsevier Scopus and Web‐of‐Science. 101 publications were reviewed, and 31 categorization variables related to the area of research and issues addressed in scientific publications were created. Using a multidimensional correspondence analysis, three homogeneous clusters of publications were obtained: group I refers to articles concerning enterprises of various sizes (micro, small, SME, and start‐up); group II includes publications on Asia and Australia, which appeared in 2020 or later; group III concerns articles related to the research of large production companies in developed European countries. The result shows that companies build sustainable value in various ways, influenced by company's location and size. Among the dominant patterns of incorporating sustainable value, the following are indicated: building a sustainable supply chain, innovations, building relationships with stakeholders and consumers, sharing economy.
Off‐host survival of blacklegged ticks in eastern North America: A multistage, multiyear, multisite study
Authors: Brunner Jesse L. , LaDeau Shannon L. , Killilea Mary , Valentine Elizabeth , Schierer Megan , Ostfeld Richard S. 
Published: March 2023

AbstractClimatic conditions are widely thought to govern the distribution and abundance of ectoparasites, such as the blacklegged tick (Ixodes scapularis), vector of the agents of Lyme disease and other emerging human pathogens. However, translating physiological tolerances to distributional limits or mortality is challenging. Ticks may be able to avoid or tolerate unsuitable conditions, and what is lethal to one life history stage may not extend to others. Thus, even after decades of research, there are clear gaps in our knowledge about how climatic conditions determine tick distributions or patterns of abundance. We present results from a 3‐year study combining daily hazard models and data from field experiments at three sites spanning much of I. scapularis' current latitudinal distribution. We examine three predominant hypotheses regarding how temperature and vapor pressure deficits affect stage‐specific survival and transition success and consider how these results influence population growth and distribution. We found that larvae are sensitive to temperature and vapor pressure deficits, whereas mortality of nymphs and adults is consistent with depletion of energy reserves. Consistent with prior work, we found that overwinter survival was high and successful stage transitions (e.g., fed nymphs molting to adults) were sensitive to temperature. Collectively, results from this comprehensive, multiyear, multistage field study suggest that population growth of I. scapularis is less limited by restrictive climatic conditions than has been broadly assumed, although influences on larval survival may slow tick population growth and establishment in some desiccating conditions. Further studies should integrate climate effects on stage‐specific survival to better understand these effects on population dynamics and range expansion in a changing climate.