bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of cobalt and magnesium doping on the performance of Ba0.5Sr0.5Fe0.8O3 cathode for solid oxide fuel cell applications
Authors: Subhashini P V C K , Rajesh K V D 
Published: September 2023

Abstract
The chemical composition of the cathode material influences the performance of the low temperature solid oxide fuel cells (SOFCs). In the present work, two different cathode materials (Ba0.5Sr0.5Co0.2Fe0.8O3 and Ba0.5Sr0.5Mg0.2Fe0.8O3) were prepared to assess the role of Mg in the place of Co on the performance of the SOFC. Symmetric cells were fabricated by using Gadolinium doped Cerium (GDC) electrolyte. From the X-ray diffraction analysis, the lattice parameter was measured as increased from 3.954 Å to 3.975 Å for the cathode with the presence of Mg compared with Co. On the other hand, Mg decreased the electric conductivity (35 ± 1.6 S cm−1) compared with Co doping (56 ± 2.4 S cm−1). Higher porosity (4.8%) was observed in the cathode material with Mg which resulted in more triple phase boundaries and promoted higher gas diffusion. Lower polarization resistance (RP) values (7.95 and 1.07 Ω-cm2) were recorded at 600 °C and 700 °C respectively for the fuel cells fabricated with cathode having Mg compared with Co.
Common garden experiments reveal acquisitive strategies for responding to drought in seedlings of forest tree species: a commentary on ‘Clinal variations in seedling traits and responses to water availability correspond to seed-source environmental gradients in a foundational dryland tree species’
Authors: Solé-Medina Aida , Ramírez-Valiente José Alberto 
Published: September 2023

This article comments on:
Georgia L. Vasey, Alexandra K. Urza, Jeanne C. Chambers, Elizabeth G. Pringle and Peter J. Weisberg. Clinal variations in seedling traits and responses to water availability correspond to seed-source environmental gradients in a foundational dryland tree species, Annals of Botany, Volume 132, Issue 2, 25 July 2023, Pages 203–216, https://doi.org/10.1093/aob/mcad041
Remaking Thucydides
Authors: Morley Neville 
Published: September 2023

Abstract
All attempts at realizing Thucydides’ promise of ‘a possession for all time’ involve some degree of remaking: the translation of the text, at the least, but more commonly also processes of selection, decontextualization, simplification, and framing, as well as the development of an image of the author that legitimizes present-orientated readings. This is particularly obvious in the case of interpretations that present Thucydides as a conventional academic authority, where, however, the processes of remaking are largely suppressed or denied in the interests of claiming Thucydides’ authority―this is what he really meant―to support modern ideas. This paper explores the greater latitude available to those engaging with his work in fictional and dramatic contexts―the authors Anne Carson and Virginia Woolf, and theatrical stagings of the Melian Dialogue (even as an immersive interactive experience)―to suggest that these may in fact be a truer reflection of some aspects of the Thucydidean project.
SARS-CoV-2 sublingual vaccine with RBD antigen and poly(I:C) adjuvant: Preclinical study in cynomolgus macaques
Authors: Yamamoto Tetsuro , Tanji Masanori , Mitsunaga Fusako , Nakamura Shin 
Published: September 2023

Abstract
Mucosal vaccine for sublingual route was prepared with recombinant SARS-CoV-2 spike protein receptor binding domain (RBD) antigen and poly(I:C) adjuvant components. The efficacy of this sublingual vaccine was examined using Cynomolgus macaques. Nine of the macaque monkeys were divided into three groups of three animals: control [just 400 µg poly(I:C) per head], low dose [30 µg RBD and 400 µg poly(I:C) per head], and high dose [150 µg RBD and 400 µg poly(I:C) per head], respectively. N-acetylcysteine (NAC), a mild reducing agent losing mucin barrier, was used to enhance vaccine delivery to mucosal immune cells. RBD-specific IgA antibody secreted in pituita was detected in two of three monkeys of the high dose group and one of three animals of the low dose group. RBD-specific IgG and/or IgA antibodies in plasma were also detected in these monkeys. These indicated that the sublingual vaccine stimulated mucosal immune response to produce antigen-specific secretory IgA antibodies in pituita and/or saliva. This sublingual vaccine also affected systemic immune response to produce IgG (IgA) in plasma. Little RBD-specific IgE was detected in plasma, suggesting no allergic antigenicity of this sublingual vaccine. Thus, SARS-CoV-2 sublingual vaccine consisting of poly(I:C) adjuvant showed reasonable efficacy in a non-human primate model.
Autosomal dominant in cis D4Z4 repeat array duplication alleles in facioscapulohumeral dystrophy
Authors: Lemmers Richard J L F , Butterfield Russell , van der Vliet Patrick J , de Bleecker Jan L , van der Pol Ludo , Dunn Diane M , Erasmus Corrie E , D'Hooghe Marc , Verhoeven Kristof , Balog Judit , Bigot Anne , van Engelen Baziel , Statland Jeffrey , Bugiardini Enrico , van der Stoep Nienke , Evangelista Teresinha , Marini-Bettolo Chiara , van den Bergh Peter , Tawil Rabi , Voermans Nicol C , Vissing John , Weiss Robert B , van der Maarel Silvère M 
Published: September 2023

Abstract
Facioscapulohumeral dystrophy (FSHD) has a unique genetic aetiology resulting in partial chromatin relaxation of the D4Z4 macrosatellite repeat array on 4qter. This D4Z4 chromatin relaxation facilitates inappropriate expression of the transcription factor DUX4 in skeletal muscle. DUX4 is encoded by a retrogene that is embedded within the distal region of the D4Z4 repeat array. In the European population, the D4Z4 repeat array is usually organized in a single array that ranges between 8 and 100 units. D4Z4 chromatin relaxation and DUX4 derepression in FSHD is most often caused by repeat array contraction to 1–10 units (FSHD1) or by a digenic mechanism requiring pathogenic variants in a D4Z4 chromatin repressor like SMCHD1, combined with a repeat array between 8 and 20 units (FSHD2).
With a prevalence of 1.5% in the European population, in cis duplications of the D4Z4 repeat array, where two adjacent D4Z4 arrays are interrupted by a spacer sequence, are relatively common but their relationship to FSHD is not well understood. In cis duplication alleles were shown to be pathogenic in FSHD2 patients; however, there is inconsistent evidence for the necessity of an SMCHD1 mutation for disease development.
To explore the pathogenic nature of these alleles we compared in cis duplication alleles in FSHD patients with or without pathogenic SMCHD1 variant. For both groups we showed duplication-allele-specific DUX4 expression. We studied these alleles in detail using pulsed-field gel electrophoresis-based Southern blotting and molecular combing, emphasizing the challenges in the characterization of these rearrangements. Nanopore sequencing was instrumental to study the composition and methylation of the duplicated D4Z4 repeat arrays and to identify the breakpoints and the spacer sequence between the arrays. By comparing the composition of the D4Z4 repeat array of in cis duplication alleles in both groups, we found that specific combinations of proximal and distal repeat array sizes determine their pathogenicity. Supported by our algorithm to predict pathogenicity, diagnostic laboratories should now be furnished to accurately interpret these in cis D4Z4 repeat array duplications, alleles that can easily be missed in routine settings.
Renewable energy in Benin: current situation and future prospects
Authors: Akpahou Romain , Mensah Lena D , Quansah David A 
Published: September 2023

Abstract
To provide clean energy at a lower cost to their citizens, all nations of the world are striving to increase their energy production in an environmentally friendly way. Benin has also joined this dynamic by considerably increasing its green energy production efforts in recent years. The country has a huge undeveloped renewable-energy (RE) potential that can contribute considerably to its national energy production capacity. This paper summarizes the current RE situation in Benin and examines its future prospects. The current energy situation of the country is discussed, followed by an examination of its electricity demand-and-supply situation. The country has been found to depend heavily on natural gas and petroleum products from neighbouring countries and has ~41% of national electricity access. However, the government is taking considerable steps to implement RE projects in the country. The study analyzes government targets in the energy sector with existing policies and institutional frameworks. Recommendations are made for the benefit of the government, the private sector and other actors in order to developing the RE potential of Benin.
The role of distractors in rapid serial visual presentation reveals the mechanism of attentional blink by EEG-based univariate and multivariate analyses
Authors: Meng Zong , Chen Qi , Zhou Liqin , Xu Liang , Chen Antao 
Published: September 2023

Abstract
Attentional blink pertains to the performance of participants with a severe decline in identifying the second target presented after the first target reported correctly within 200–500 ms in a rapid serial visual presentation. The current study was conducted to investigate the neural mechanism of the effect of the distractor (D1) that immediately follows first target to attentional blink by altering whether D1 was substituted with a blank with electroencephalography recording. The results showed that D1 interfered with the attentional enhancement and working memory encoding in both single-target rapid serial visual presentation task and dual-target rapid serial visual presentation task, which were mainly manifested in delayed and attenuated P3a and diminished P3b of first target. Single-trial analysis indicated that first target and second target will compete with each other for working memory encoding resources in short lag, but not in the long lag. In addition, D1 interfered with the working memory encoding of second target under short lag rather than long lag in the dual-target rapid serial visual presentation task. These results suggested that attentional blink can be attributed to the limited working memory encoding resource, whereas the amount of available resources is subject to modulation by attention. The D1 hinders the attention enhancement of first target, thereby exacerbating attentional blink.
Decision aids to assist patients and professionals in choosing the right treatment for kidney failure
Authors: Bekker Hilary L , Winterbottom Anna E , Gavaruzzi Teresa , Finderup Jeanette , Mooney Andrew 
Published: September 2023

ABSTRACTBackgroundKidney services vary in the way they involve people with kidney failure (PwKF) in treatment decisions as management needs change. We discuss how decision-science applications support proactively PwKF to make informed decisions between treatment options with kidney professionals.MethodsA conceptual review of findings about decision making and use of decision aids in kidney services, synthesized with reference to: the Making Informed Decisions—Individually and Together (MIND-IT) multiple stakeholder decision makers framework; and the Medical Research Council—Complex Intervention Development and Evaluation research framework.ResultsThis schema represents the different types of decision aids that support PwKF and professional reasoning as they manage kidney disease individually and together; adjustments at micro, meso and macro levels supports integration in practice.ConclusionInnovating services to meet clinical guidelines on enhancing shared decision making processes means enabling all stakeholders to use decision aids to meet their goals within kidney pathways at individual, service and organizational levels.
CBPDdb: a curated database of compounds derived from Coumarin–Benzothiazole–Pyrazole
Authors: Rampogu Shailima , Shaik Mohammed Rafi , Khan Merajuddin , Khan Mujeeb , Oh Tae Hwan , Shaik Baji 
Published: September 2023

Abstract
The present article describes the building of a small-molecule web server, CBPDdb, employing R-shiny. For the generation of the web server, three compounds were chosen, namely coumarin, benzothiazole and pyrazole, and their derivatives were curated from the literature. The two-dimensional (2D) structures were drawn using ChemDraw, and the .sdf file was created employing Discovery Studio Visualizer v2017. These compounds were read on the R-shiny app using ChemmineR, and the dataframe consisting of a total of 1146 compounds was generated and manipulated employing the dplyr package. The web server is provided with JSME 2D sketcher. The descriptors of the compounds are obtained using propOB with a filter. The users can download the filtered data in the .csv and .sdf formats, and the entire dataset of a compound can be downloaded in .sdf format. This web server facilitates the researchers to screen plausible inhibitors for different diseases. Additionally, the method used in building the web server can be adapted for developing other small-molecule databases (web servers) in RStudio.
Database URL: https://srampogu.shinyapps.io/CBPDdb_Revised/
Au Nom de la Patrie: Southern Identities and Patriotic Mobilisation in First World War France
Authors: Purseigle Pierre 
Published: September 2023

Abstract
At the outbreak of the First World War in August 1914, many French commentators doubted that France had the strength to withstand the trials of war. Yet the national mobilisation for war was an indisputable success that surprised military planners and political leaders alike. Despite inauspicious beginnings and the unprecedented material and human costs of war, France held out, and the Republican nation-state emerged victorious and to a large extent reinforced by the war. However, the subsequent failure to mobilise successfully in 1939–40 begs the question of the nature and transformation of French patriotism in the First World War. Interestingly, in a field characterised by its vibrant, sophisticated and highly contentious debates, French historians appear to have skirted around the problem of patriotic mobilisation. This article reconsiders this question by investigating social mobilisation in the country’s southern periphery, focusing on the town of Béziers. It underlines the need to locate patriotism by considering its valence in the particular social and geographic contexts that determined the war experience at the front or at home. It also suggests the necessity to re-politicise the idea of national sentiment while maintaining the necessary distinction between patriotism and nationalism. Finally, it argues that the analysis of wartime mobilisation in France must be part of a larger reflection on the mobilisation of space and place in the era of the Great War.
A synthesis of US Atlantic salmon habitat requirements and implications for future suitability under a changing climate
Authors: Henderson M E , Mills K E , Alexander M A , Barajas M , Collins M J , Dzaugis M , Kircheis D , Sheehan T F 
Published: September 2023

Abstract
The Gulf of Maine hosts the southernmost remaining population of North American Atlantic salmon. Despite extensive hatchery supplementation since the late 1800s, and more recent riverine habitat restoration efforts and fishing restrictions, US-origin Atlantic salmon populations continue to decline and have remained at low abundance over recent decades. Climate change has been identified as a critical threat to the future of US Atlantic salmon. In this study, we synthesized available information on how habitats used by Atlantic salmon across all their life stages will be affected by climate change as well as the suitability of future conditions for salmon’s persistence in the region. Maintaining sufficient cool water refugia during increasing summer temperatures in riverine habitats is required for sustaining salmon in the future. Changes in groundwater quantity and temperature, which will depend on future precipitation and temperature, will be critical factors for river temperatures, as will land use and land cover. While Atlantic salmon’s freshwater life stages are heavily documented, the marine phase is relatively less studied. Climate models predict basin-scale changes over the next century, but impacts to salmon are difficult to predict. Furthermore, disparate drivers and differential rates of change between freshwater and marine habitats could present an obstacle to the transition between phases in the future. We have a general understanding of migration patterns and prey preferences but lack a clear picture of how salmon respond to habitat and ecosystem-level changes associated with climate change progression. More research to understand freshwater habitat changes and salmon’s marine spatiotemporal distribution responses will enhance capacities to evaluate future risks and predict impacts of climate change to US-origin Atlantic salmon.
Unmet Needs in the Post–Direct-Acting Antiviral Era: Hepatocarcinogenesis After Hepatitis C Virus Eradication
Authors: Przybyszewski Eric M , Chung Raymond T 
Published: September 2023

Abstract
Infection with chronic hepatitis C virus (HCV) is an important risk factor for hepatocellular carcinoma (HCC). Direct-acting antiviral therapy has transformed care for patients with HCV and reduces the risk of HCC. Despite HCV cure, a residual HCC risk remains in patients with advanced fibrosis and cirrhosis, with multiple mechanisms underlying subsequent hepatocarcinogenesis. Transcriptomic and proteomic signatures demonstrate the capacity for HCC risk stratification, and chemoprevention strategies are emerging. For now, pending more precise stratification, HCC surveillance of patients with cured HCV and advanced fibrosis or cirrhosis should continue.
Policy and Strategy for Hepatitis C Virus Elimination at the National Level: Experience in Taiwan
Authors: Chien Rong-Nan , Lu Sheng-Nan , Hui-Min Wu Grace , Yang Wen-Wen , Pwu Raoh-Fang , Liu Chia-Ling , Cheng Kuo-Pen , Chen Shih-Chung , Chen Chien-Jen 
Published: September 2023

Abstract
The estimated prevalence of anti-HCV was 3.1% in Taiwan. Studies have shown iatrogenic behavior was the major transmission route. It is highest in specific populations including patients with end stage renal disease (ESRD), human immunodeficiency virus infection, who inject drug (PWID), and under opioid substitution treatment. Approximately 405,160 patients were seropositive for HCV RNA and in need of treatment.
Taiwan government claims to reach WHO’s 2030 goal of HCV elimination by 2025 and works hard to resolve several barriers of HCV elimination including political commitment, sustainable financing, minimize reimbursement restrictions, instituted monitoring, and perform micro-elimination of specific populations. The last stage of HCV elimination is to accelerate the universal HCV screening program of populations aged 45-79 years and resolve the unawareness issue of HCV infection. Hopefully, we can achieve the targets of HCV elimination set by WHO and reach the goal earlier in 2025.
Strategies for Removal of Barriers to Hepatitis C Elimination in Sub-Saharan Africa
Authors: Umutesi Justine , Yu Ming-Lung , Lesi Olufunmilayo , Ward John W , Serumondo Janvier 
Published: September 2023

Abstract
Hepatitis C virus (HCV) infection is a major global health threat, with serious consequences including liver cirrhosis and cancer. Despite efforts to combat HCV, an estimated 1.5 million new infections occur each year and HCV was the sixth leading cause of death in 2017. Nevertheless, political leaders are increasingly interested in the fight against HCV, and the achievements of countries such as Rwanda, Egypt, India, Mongolia, Pakistan, Georgia, and Ukraine have given hope that the elimination plan to reduce new infections to 90% and mortality to 65% by 2030 is possible. It is true that some African countries can attest to the difficulty of operationalizing the HCV program with expensive testing platforms and HCV drugs that few could afford in the past, let alone the logistics involved, given that active case detection is an asset for HCV elimination. The inability to add direct-acting antivirals (DAAs) to the national essential drug list and negotiate DAA cost subsidies remains a major challenge in Africa. The lessons learned from implementing and scaling up the human immunodeficiency virus program can provide a strong framework to deliver comprehensive HCV services. We present the strategies used by some African countries to move toward HCV elimination, describe the challenges they have faced, and suggest realistic solutions.
Comprehensive toxicological screening of common drugs of abuse, new psychoactive substances and cannabinoids in blood using supported liquid extraction and liquid chromatography–quadrupole time-of-flight mass spectrometry
Authors: Ayala Jessica , Kerrigan Sarah 
Published: September 2023

Abstract
Immunoassay (IA) is currently the most widely used technique for toxicological screening in drug-impaired driving investigations. However, practical limitations in the scope of testing, and the emergence of new psychoactive substances (NPSs), have highlighted the need for alternative approaches, particularly mass spectrometry-based screening. High-resolution mass spectrometry broadens the scope of testing to include NPSs and increases analyte specificity compared to IA. In addition, it provides a platform with increased flexibility and adaptability to incorporate emerging drugs of interest due to the transient drug market. In this study, a comprehensive screening procedure was developed to identify &gt;200 drugs of interest, including cannabinoids and NPSs in whole blood. Supported liquid extraction and liquid chromatography–quadrupole time-of-flight mass spectrometry using All Ions data acquisition were used. The method was validated in accordance with published recommendations, and all compounds of interest were identified at recommended cutoffs for driving under the influence of drug investigations. Cannabinoids, including 11-nor-9-carboxy-∆9-tetrahydrocannabinol, fentanyl analogs, buprenorphine, novel synthetic opioids and synthetic cannabinoids, were identified at low- to sub-nanogram/milliliter concentrations in whole blood using both positive and negative electrospray ionization acquisition methods.