bluuebunny/crossref_metadata_2025_split huggingface dataset:
The presence and severity of epilepsy coincide with reduced γ‐aminobutyrate and cortical excitatory markers in succinic semialdehyde dehydrogenase deficiency
Authors: Tokatly Latzer Itay , Bertoldi Mariarita , DiBacco Melissa L. , Arning Erland , Tsuboyama Melissa , MacMullin Paul , Sachee Daniyal , Rotenberg Alexander , Lee Henry H. C. , Aygun Deniz , Opladen Thomas , Jeltsch Kathrin , García‐Cazorla Àngels , Roullet Jean‐Baptiste , Gibson K. Michael , Pearl Phillip L. 
Published: March 2023

AbstractObjectiveSuccinic semialdehyde dehydrogenase deficiency (SSADHD) is a rare inherited metabolic disorder caused by a defect of γ‐aminobutyrate (GABA) catabolism. Despite the resultant hyper‐GABAergic environment facilitated by the metabolic defect, individuals with this disorder have a paradoxically high prevalence of epilepsy. We aimed to study the characteristics of epilepsy in SSADHD and its concordance with GABA‐related metabolites and neurophysiologic markers of cortical excitation.MethodsSubjects in an international natural history study of SSADHD underwent clinical assessments, electroencephalography, transcranial magnetic stimulation (TMS), magnetic resonance spectroscopy for GABA/N‐acetyl aspartate quantification, and plasma GABA‐related metabolite measurements.ResultsA total of 61 subjects with SSADHD and 42 healthy controls were included in the study. Epilepsy was present in 49% of the SSADHD cohort. Over time, there was an increase in severity in 33% of the subjects with seizures. The presence of seizures was associated with increasing age (p = .001) and lower levels of GABA (p = .002), γ‐hydroxybutyrate (GHB; p = .004), and γ‐guanidinobutyrate (GBA; p = .003). Seizure severity was associated with increasing age and lower levels of GABA‐related metabolites as well as lower TMS‐derived resting motor thresholds (p = .04). The cutoff values with the highest discriminative ability to predict seizures were age > 9.2 years (p = .001), GABA < 2.57 μmol·L−1 (p = .002), GHB < 143.6 μmol·L−1 (p = .004), and GBA < .075 μmol·L−1 (p = .007). A prediction model for seizures in SSADHD was comprised of the additive effect of older age and lower plasma GABA, GHB, and GBA (area under the receiver operating characteristic curve of .798, p = .008).SignificanceEpilepsy is highly prevalent in SSADHD, and its onset and severity correlate with an age‐related decline in GABA and GABA‐related metabolite levels as well as TMS markers of reduced cortical inhibition. The reduction of GABAergic activity in this otherwise hyper‐GABAergic disorder demonstrates a concordance between epileptogenesis and compensatory responses. These findings may furthermore inform the timing of molecular interventions for SSADHD.
High landscape‐scale forest cover favours cold‐adapted plant communities in agriculture–forest mosaics
Authors: Borderieux Jeremy , Gégout Jean‐Claude , Serra‐Diaz Josep M. 
Published: March 2023

AbstractAimThe ongoing climate warming is expected to reshuffle understorey plant community composition by increasing the occurrence of warm‐adapted species at the expense of cold‐adapted species. This process has been evidenced before by a warming community temperature index (CTI) over time. However, data indicate that the local tree canopy can partly explain an observed lag between understorey plant CTI and climate warming rates, though landscape‐scale forest cover effects have not yet been investigated. Here, we test the hypothesis that the amount of forest cover in the landscape lowers local CTI.LocationTemperate forests in France.Time period2005–2019.Major taxa studiedForest vascular plants.MethodsWe compared 2,012 pairs of neighbouring French forest inventory plots with contrasting percentages of forest cover within a 1‐km radius area (landscape forest cover). We computed the difference in the CTI of the understorey communities for each pair and tested the contributions of the landscape‐scale forest cover, local canopy cover, and soil conditions to the differences in CTI.ResultsPlots located in highly forested areas (> 80% in the 1‐km area) had an average CTI 0.26 °C lower (0.81 °C SD) than plots in sparsely forested areas (< 30% in the 1‐km area). Fifty percent of this difference was explained by landscape‐scale forest cover. Bioindicated soil conditions such as pH and available nutrients, which correlated with cold‐adapted species preferences, explained the remaining 50%.Main conclusionsHighly forested landscapes allow cold‐adapted species to survive in given macroclimatic conditions. These landscapes meet cold‐adapted species’ soil requirements and may cool the regional climate. Further microclimatic studies are needed to confirm the cooling capacity of landscape‐scale forest cover.
Examining differences in children and adolescents' exposure to food and beverage marketing in Canada by sociodemographic characteristics: Findings from the International Food Policy Study Youth Survey, 2020
Authors: Acton Rachel B. , Bagnato Mariangela , Remedios Lauren , Potvin Kent Monique , Vanderlee Lana , White Christine M. , Hammond David 
Published: March 2023

SummaryBackgroundMany countries, including Canada, are considering regulations to restrict food and beverage marketing to children. However, little evidence is available outside of the US on how marketing exposure differs across sociodemographic subgroups.ObjectiveTo investigate potential associations between child and adolescent sociodemographic characteristics and exposure to food and beverage marketing in Canada.MethodsParticipants (n = 3780) aged 10–17 self‐reported exposure to food and beverage marketing across food categories, locations and marketing techniques. Logistic regression models tested relationships between sociodemographics (age, sex, ethnicity and income adequacy) and marketing exposure.ResultsAmong other differences identified, 13–17 years old were more likely than 10–12 years old to report seeing unhealthy food marketing online. Girls were more likely than boys to see such marketing online and in retail settings, while boys were more likely to see it in video games. Minority ethnicities (including Indigenous youth) and respondents with lower income adequacy generally reported more exposure than White and higher income respondents, respectively.ConclusionsThis study highlights important differences in marketing exposure among youth of different sociodemographic groups in Canada, including greater exposure to marketing among those most disadvantaged and emphasizes the essential need to consider food marketing across equity groups when developing restrictions on marketing to kids.
Predictors of burnout for immigrant mental health professionals in the United States
Authors: Farrell Isabel C. , Basma Dareen , DeDiego Amanda C. , Maurya Rakesh K. , Hurt‐Avila Kara M. 
Published: March 2023

AbstractMental health professionals who identify as immigrants encounter personal and professional barriers that can impact overall wellbeing. The current study conducted a survey of 108 licensed mental health professionals who identify as immigrants practicing in the United States. The survey included demographics as well as assessments of burnout, social support, and migratory grief and loss. The results of this study highlighted that a combination of higher migratory grief and lower perceived social support significantly predicted higher levels of burnout in mental health professionals. Implications for mental health programs, supervisors, and mentors and suggestions for future research are provided.
Effect of hydrocolloid dressing combined with low molecular weight heparin and calcium on scar hyperplasia in burn patients with venous thromboembolism
Authors: Li Chengzhi , Wang Yuanyuan , Hu Fan , Gong Hui 
Published: March 2023

AbstractThe purpose of this study is to investigate the effect of hydrocolloid dressing combined with low molecular weight heparin calcium on scar hyperplasia in burn patients with venous thromboembolism. A retrospective analysis was made on 98 patients with burns complicated with venous thromboembolism in Renmin Hospital, Hubei University of Medicine from January 2020 to April 2021. According to different treatment methods, they were divided into a control group (48 cases) and a research group (50 cases), who were given low molecular weight heparin calcium combined with routine treatment and hydrocolloid dressing on the basis of the control group. The wound healing time, dressing change times and infection symptom regression time in the study group were significantly lower than those in the control group (P < .05). After the intervention, the degree of wound pain in both groups was reduced, and the degree of wound pain in the study group was significantly lower than that in the control group, with statistical significance (P < .05). Fibrinogen, activated partial thromboplastin (APPT), D‐dimer, fibrinolytic degradation products, prothrombin time and activated partial prothrombin time of the two groups were all improved. The degree of scar hyperplasia in both groups was improved, and the degree of scar hyperplasia in the study group was significantly better than that in the control group, and the difference was statistically significant (P>.05). Complications in the study group were lower than those in the control group, and the difference was statistically significant (P < .05). The hydrocolloid dressing combined with low molecular weight heparin calcium can effectively shorten the wound healing time and infection symptom regression time of burn patients with venous thromboembolism, reduce the number of dressing changes, reduce the degree of pain, have no influence on coagulation function, reduce the degree of scar, and reduce the incidence of complications.
Detecting Group Collaboration Using Multiple Correspondence Analysis
Authors: Grochowalski Joseph H. , Hendrickson Amy 
Published: March 2023

AbstractTest takers wishing to gain an unfair advantage often share answers with other test takers, either sharing all answers (a full key) or some (a partial key). Detecting key sharing during a tight testing window requires an efficient, easily interpretable, and rich form of analysis that is descriptive and inferential. We introduce a detection method based on multiple correspondence analysis (MCA) that identifies test takers with unusual response similarities. The method simultaneously detects multiple shared keys (partial or full), plots results, and is computationally efficient as it requires only matrix operations. We describe the method, evaluate its detection accuracy under various simulation conditions, and demonstrate the procedure on a real data set with known test‐taking misbehavior. The simulation results showed that the MCA method had reasonably high power under realistic conditions and maintained the nominal false‐positive level, except when the group size was very large or partial shared keys had more than 50% of the items. The real data analysis illustrated visual detection procedures and inference about the item responses possibly shared in the key, which was likely shared among 91 test takers, many of whom were confirmed by nonstatistical investigation to have engaged in test‐taking misconduct.
How capital intensity affects technical progress: An empirical analysis for 17 advanced economies
Authors: Bellocchi Alessandro , Travaglini Giuseppe , Vitali Beatrice 
Published: March 2023

AbstractIn this paper we present a model of economic growth with endogenous technical progress. We test if the neoclassical growth model accepts the assumption that capital intensity affects Total Factor Productivity (TFP) in the long run. Our view takes inspiration from Kaldor's growth model of 1957 in which theTechnical Progress Function(TPF) responds to the joint behavior of capital intensity and inventiveness. We find that “movements along a production function cannot be distinguished from shifts in this function” as formalized by the TPF. The model is tested using a Structural VAR for 17 advanced economies, over the period 1980–2020. On impact, when capital intensity improves, TFP increases sharply. This response is large and persistent over time and explains about half as much as of measured TFP. It confirms that capital intensity is an omitted variable in the traditional scheme used to estimate technical progress. Notably, the standard neoclassical growth model is not consistent with this evidence. Our analysis also shows that demand shocks can have permanent effects on output and unemployment. Finally, monetary policy helps to stabilize the business cycle, but loses its effectiveness in the long run.
Verification of technical change and cost and productivity criteria: An empirical study using the World Input–Output Database
Authors: Hashimoto Takahiko 
Published: March 2023

AbstractThis study examines the different types of technical change, as categorized by the productivity and cost criteria proposed by previous theoretical studies using data from the World Input–Output Database. The results confirm that in some sectors, the cost criteria are satisfied, but the productivity criteria are not. These technological changes are due to the very large labor input of imported intermediates and the higher monetary wage rate of the recipient country than that of the country supplying the imported intermediates. This study is a valid objection to previous theoretical studies.
Richard Rorty's realism
Authors: Earle William James 
Published: March 2023

AbstractAn examination of late Rorty shows that he does not abandon belief in an external world about which we can, and indeed must, acquire knowledge. His disapproval of the correspondence theory of truth does not involve the idea that anything other than local weather, for example, could falsify remarks about local weather. It is just that once we get done looking out the window or, if we are outside, feeling the right kind of drops make contact with our skin, there is nothing else we can do, nothing better, to make ourselves more certain, more cognitively secure. One can see this in the detailed work that enables scientific progress. Science improves itself by doing more of the same. G. E. Moore's famous open question stays open only as a reminder that our fallibility never disappears and that our cognitive security is never better than pro tem. Rorty, as a faithful pragmatist and undogmatic meliorist, thinks this is perfectly O.K.
Isolated cortical venous thrombosis: A systematic review
Authors: Montalvan Victor , Duarte‐Celada Walter , Bueso Tulio , Lee Jeannie , Rivas Katherine , Neves Gabriel , Tan Yuanyuan , Ferdous Jannatul 
Published: March 2023

AbstractBackgroundIsolated cortical venous thrombosis (ICVT) is an uncommon subtype of cerebral venous thrombosis that only affects the cortical veins on the cerebral convexities. Its clinical presentation is variable and may mimic other neurological conditions.ObjectiveWe performed a systematic review using PRISMA guidelines of the available literature on ICVT.MethodsWe reviewed articles in PubMed, SCOPUS, and EMBASE databases. We presented the evidence in sections in this manuscript, including epidemiology, clinical presentation, pathophysiology, radiological findings, and proposed treatment.ResultsOf a total of 199 screened studies, we included 39 studies in the final analysis. Of those, 10 were systematic reviews, 11 were case reports, and 18 were case series related to ICVT. Seizures and headaches are the most common symptoms of ICVT. Magnetic resonance venography (MRV) is the diagnostic modality of choice. The standard of care in these cases is therapeutic anticoagulation with heparin and evaluation of an underlying hypercoagulable condition. A half of the patients might require antiepileptic drugs. Osmotherapy and craniectomy are rarely used, and mechanical thrombectomy does not seem to play a role in this patient's treatment.ConclusionIsolated cortical venous thrombosis involves the cortical veins without involvement of the venous sinuses. Patients who usually present with focal seizures and headaches in the absence of a clear cause, the diagnosis of ICVT should be considered. MRV is the diagnostic modality of choice. Therapeutic anticoagulation is the standard of care. More research is required to clarify the role of novel anticoagulants and the duration of the therapy.
The association of gestational age at birth with trajectories of early childhood developmental delay among late preterm and early term born children: A longitudinal analysis of All Our Families pregnancy cohort
Authors: Stephenson Nikki , Metcalfe Amy , McDonald Sheila , Williamson Tyler , McMorris Carly , Tough Suzanne 
Published: March 2023

AbstractBackgroundLike infants born very preterm (<32 weeks), late preterm (≥34 and <37 weeks) and early term (≥37 and <39 weeks) births have been associated with increased risk of developmental delay (DD); yet, the evidence remains heterogeneous across the continuum of gestational ages, hindering early identification and intervention.ObjectiveTo estimate the association of gestational age at birth with early childhood trajectories of DD in early childhood for infants born ≥34 and <41 weeks, and determine how various maternal, pregnancy and infant characteristics relate to these trajectory groups.MethodsAnalysis of mother–child dyad data with infants born ≥34 and <41 weeks gestational age within an observational pregnancy cohort in Alberta, Canada, from 2008 to 2011 (n = 2644). The association between gestational age and trajectories of the total number of Ages and Stages Questionnaire domains indicating risk of DD from 1 through 5 years of age were estimated using group‐based trajectory modelling along with other perinatal risk factors.ResultsThree distinct trajectory groups were identified: low‐risk, moderate‐risk (transiently at risk of DD in one domain over time) and high‐risk (consistently at risk of delay in ≥2 domains over time). Per week of decreasing gestational age, the risk ratio of membership in the high‐risk group increases by 1.77 (95% confidence interval [CI] 1.43, 2.20) or 1.84 (95% CI 1.49, 2.27) relative to the moderate‐risk and low‐risk respectively. Increasing maternal age, identifying as Black, indigenous or a person of colour, elevated maternal depressive symptoms in pregnancy, and male infant sex were associated with high‐ and moderate‐risk trajectories compared to the low‐risk trajectory.ConclusionsIn combination with decreasing gestational age, poor maternal mental health and social determinants of health increase the probability of membership in trajectories with increased risk of DD, suggesting that additional monitoring of children born late preterm and early term is warranted.
Successful lactation induction in non‐pregnant gilts
Authors: Cordeiro Ágatha Decroix , Conterato Ana Júlia B. , Bianchi Ivan , Dartora Débora L. A. , Zanella Ricardo , Bondan Carlos , Marques Mariana G. , Gasperin Bernardo G. , Lucia Thomaz 
Published: March 2023

AbstractA protocol to induce lactation was applied to non‐pregnant gilts. In Experiment I, five gilts with oestrus synchronized through oral supplementation of 20 mg altrenogest for 18 days received: 10 mg oestradiol cypionate (EC) on the last day of oestrous expression (D0); 10 mg EC and 300 mg long‐acting progesterone (P4) on D26; and two 0.53 mg doses of a prostaglandin F2α analogue (PGF) 12 h apart on D36. Blood was collected on D12, D19, D26 and D33. Milk secretion started in all gilts 24 h after PGF administration and lasted at least 8 days. Milk samples were collected from D37 to D45. The serum P4 concentration was lower on D12 than subsequently (p < .05), but the oestradiol concentration was unaltered (p > .05). The milk produced during the induced lactation was generally richer in protein and poorer in fat compared to the milk from the lactation of a reference sow. In Experiment II, the same protocol induced lactation in two gilts, which nursed fostered piglets for 22 days. Thus, lactation was induced in all treated gilts and the milk produced was capable to nurture fostered piglets.
Chromium Poisoning Mitigation Strategy in Strontium-Doped Lanthanum Manganite-Based Air Electrodes in Solid Oxide Fuel Cells
Authors: Sugimoto Michelle , Zhu Zhikuan , Gopalan Srikanth , Basu Soumendra , Pal Uday B. 
Published: March 2023

Abstract
Chromium poisoning of the air electrode remains an obstacle to the long-term performance of solid oxide fuel cells (SOFCs). In Sr-doped LaMnO3 (LSM) air electrodes, the poisoning process results in two types of deposits, chromium oxide (Cr2O3), and Mn, Cr spinel (MnCr2O4). The former forms electrochemically and the latter forms via a chemical reaction. By applying a small anodic reverse bias, Cr2O3 deposits can be removed because their formation is electrochemical in nature. However, MnCr2O4 deposits remain because their formation is chemical, rather than electrochemical, in nature. In situ chemical decomposition of the Mn, Cr spinel was investigated as an alternate removal method as thermodynamics supports its decomposition into constituent oxides below ∼540 °C in pure oxygen. The spinel decomposition process was characterized using thermogravimetric and X-ray diffraction analyses. The experimentally determined rate of spinel decomposition was undetectable (very slow) with isolated MnCr2O4 powders. The addition of 10 mol% gadolinia doped ceria (GDC) and silver powders significantly increased the rate of decomposition. However, the rate is limited by the diffusion of oxygen through the decomposed oxide layer. Although one strategy may be the addition of GDC and silver to the LSM air electrode to enhance spinel decomposition, the more effective mitigation strategy would be to prevent the formation of MnCr2O4 spinel in the first place through the removal of the reactants: Cr2O3 via electrochemical cleaning and mobile Mn ions in the zirconia electrolyte by incorporating a diffusion barrier layer such as GDC between the air electrode and electrolyte.
Investigation on Solar Drying Characteristics of Ginger (Zingiber officinale) in a Reflector-Attached Solar Air Heater and Thermal Energy Storage System Using Nanomaterials
Authors: Sethi Chandan Kumar , Acharya Saroj Kumar , Patnaik Pragyan Parimita 
Published: March 2023

Abstract
By changing its design and materials, a solar dryer can help lower consumption and drying time. The dryer was run with a reflector-attached zigzag solar air heater thermally coated with 2% mass basis carbon nanotubes, 2% CuO, and 96% black paint with a reflector. To check the microstructure and morphology analysis of the nanopowders and coated surface, X-ray diffraction, scanning electron microscope, energy-dispersive X-ray, and elemental mapping have also been conducted. In this paper, the feasibility of the cabinet dryer with rotating trays was investigated to dry ginger slices in case of attaching an energy storage device. The moisture content of the ginger slices was successfully reduced from 90 to 12% within the time frame of 7 h 15 min. The different drying characteristics and quality parameters were evaluated and then compared in the case of the zigzag with coated surface and reflector, with coated surface and with reflector, respectively. The results show that using a reflector, it increases the air heater's outlet temperature by 10–12%, and using a coated surface increases the temperature by another 8–10%. The average thermal and exergy efficiency of an air heater was found to be 70.2 and 4.4%, respectively. The average overall thermal efficiency of carbon nanotubes + copper oxide-paraffin wax energy storage unit was 31.19%, with 11.9% as the average overall exergy efficiency. The energy storage increases the drying time by about 3 h during off-sunshine hours.