bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of rurality with utilization of palliative care and hospice among Medicare beneficiaries who died from pancreatic cancer: A cohort study
Authors: Ramkumar Niveditta , Wang Qianfei , Brooks Gabriel A. , Tosteson Anna N. A. , Wong Sandra L. , Loehrer Andrew P. 
Published: January 2023

AbstractBackgroundPancreatic cancer has a 5‐year survival of just 10%. Services such as palliative care and hospice are thus crucial in this population, yet their geographic accessibility and utilization remains unknown.AimWe studied the association between rurality of patient residence and the use of palliative care and hospice.Design, setting, and participantsCohort study of continuously enrolled fee‐for‐service Medicare beneficiaries aged ≥65 diagnosed with incident pancreatic cancer between 04/01/2016‐08/31/2018 and who died by 12/31/2018.ResultsIn this decedent cohort of 31,460 patients, 77% lived in metropolitan areas, 11% in micropolitan areas, 7% in small towns, and 5% in rural areas. Patient demographics were largely similar across rurality; however, the proportion of White, non‐Hispanic patients and social deprivation was highest in rural areas and lowest in metropolitan areas. Overall, 33% of patients used any palliative care and 77% received hospice services. After risk adjustment, there were no statistically significant differences in the use of palliative care for patients residing in metropolitan versus micropolitan, small town, or rural areas. Patients in small town (OR = 0.77, 95% CI: 0.69‐0.86) and rural areas (OR = 0.75, 95% CI: 0.66‐0.85) had lower adjusted odds of receiving hospice care compared to patients in metropolitan areas.ConclusionsThe use of palliative care services captured in Medicare was low, representing either underutilization or failure to accurately measure the extent of services used. While the overall level of hospice enrollment was high, patients in rural communities had relatively lower use of hospice services compared to those in metropolitan areas.
Tomato SlGSTU38 interacts with the PepMV coat protein and promotes viral infection
Authors: Méndez‐López Eduardo , Donaire Livia , Gosálvez Blanca , Díaz‐Vivancos Pedro , Sánchez‐Pina M. Amelia , Tilsner Jens , Aranda Miguel A. 
Published: January 2023

Summary

Pepino mosaic virus (PepMV) is pandemic in tomato crops, causing important economic losses world‐wide. No PepMV‐resistant varieties have been developed yet. Identification of host factors interacting with PepMV proteins is a promising source of genetic targets to develop PepMV‐resistant varieties.

The interaction between the PepMV coat protein (CP) and the tomato glutathione S‐transferase (GST) SlGSTU38 was identified in a yeast two‐hybrid (Y2H) screening and validated by directed Y2H and co‐immunoprecipitation assays. SlGSTU38‐knocked‐out Micro‐Tom plants (gstu38) generated by the CRISPR/Cas9 technology together with live‐cell imaging were used to understand the role of SlGSTU38 during infection. The transcriptomes of healthy and PepMV‐infected wild‐type (WT) and gstu38 plants were profiled by RNA‐seq analysis.

SlGSTU38 functions as a PepMV‐specific susceptibility factor in a cell‐autonomous manner and relocalizes to the virus replication complexes during infection. Besides, knocking out SlGSTU38 triggers reactive oxygen species accumulation in leaves and the deregulation of stress‐responsive genes.

SlGSTU38 may play a dual role: On the one hand, SlGSTU38 may exert a proviral function depending on its specific interaction with the PepMV CP; and on the other hand, SlGSTU38 may delay PepMV‐infection sensing by participating in the redox intracellular homeostasis in a nonspecific manner.
Plant‐specific histone deacetylases associate with ARGONAUTE4 to promote heterochromatin stabilization and plant heat tolerance
Authors: Yang Fangfang , Sun Yingnan , Du Xiaoxuan , Chu Zhaohui , Zhong Xuehua , Chen Xiangsong 
Published: January 2023

Summary

High temperature causes devasting effects on many aspects of plant cells and thus enhancing plant heat tolerance is critical for crop production. Emerging studies have revealed the important roles of chromatin modifications in heat stress responses. However, how chromatin is regulated during heat stress remains unclear.

We show that heat stress results in heterochromatin disruption coupled with histone hyperacetylation and DNA hypomethylation. Two plant‐specific histone deacetylases HD2B and HD2C could promote DNA methylation and relieve the heat‐induced heterochromatin decondensation. We noted that most DNA methylation regulated by HD2B and HD2C is lost upon heat stress. HD2B‐ and HD2C‐regulated histone acetylation and DNA methylation are dispensable for heterochromatin maintenance under normal conditions, but critical for heterochromatin stabilization under heat stress.

We further showed that HD2B and HD2C promoted DNA methylation through associating with ARGONAUTE4 in nucleoli and Cajal bodies, and facilitating its nuclear accumulation. Thus, HD2B and HD2C act both canonically and noncanonically to stabilize heterochromatin under heat stress.

This study not only reveals a novel plant‐specific crosstalk between histone deacetylases and key factor of DNA methylation pathway, but also uncovers their new roles in chromatic regulation of plant heat tolerance.
Planning and licensing for marine aquaculture
Authors: Falconer Lynne , Cutajar Karl , Krupandan Amalia , Capuzzo Elisa , Corner Richard A. , Ellis Tim , Jeffery Keith , Mikkelsen Eirik , Moore Heather , O'Beirn Francis X. , O'Donohoe Pauline , Ruane Neil M. , Shilland Robyn , Tett Paul , Telfer Trevor C. 
Published: January 2023

AbstractMarine aquaculture has the potential to increase its contribution to the global food system and provide valuable ecosystem services, but appropriate planning, licensing and regulation systems must be in place to enable sustainable development. At present, approaches vary considerably throughout the world, and several national and regional investigations have highlighted the need for reforms if marine aquaculture is to fulfil its potential. This article aims to map and evaluate the challenges of planning and licensing for growth of sustainable marine aquaculture. Despite the range of species, production systems and circumstances, this study found a number of common themes in the literature; complicated and fragmented approaches to planning and licensing, property rights and the licence to operate, competition for space and marine spatial planning, emerging species and diversifying marine aquaculture production (seaweed production, Integrated Multi‐Trophic Aquaculture [IMTA], nutrient and carbon offsetting with aquaculture, offshore aquaculture and co‐location and multiuse platforms), and the need to address knowledge gaps and use of decision‐support tools. Planning and licensing can be highly complicated, so the UK is used as a case study to show more detailed examples that highlight the range of challenges and uncertainty that industry, regulators and policymakers face across interacting jurisdictions. There are many complexities, but this study shows that many countries have undergone, or are undergoing, similar challenges, suggesting that lessons can be learned by sharing knowledge and experiences, even across different species and production systems, rather than having a more insular focus.
Does heart rate variability mediate the association between chronic stress, cardiorespiratory fitness, and working memory in young adults?
Authors: Looser Vera Nina , Ludyga Sebastian , Gerber Markus 
Published: January 2023

Young adulthood is a demanding development phase rendering individuals at risk for high levels of stress. While chronic stress may impair working memory maintenance, cardiorespiratory fitness is suggested to have a protective effect. Heart rate variability (HRV) contributes to this cognitive domain, but also retaliates to stress and aerobic exercise. Therefore, the present study investigated the mediating role of resting HRV on the association between chronic stress, cardiorespiratory fitness, and working memory maintenance in young healthy adults. Healthy participants (N = 115, 48% female) aged 18–35 years (M = 24.1,SD = 3.8) completed the Åstrand test on a bicycle ergometer to estimate maximal oxygen consumption [ (ml/min/kg)]. In addition, working memory maintenance was assessed using the modified Sternberg task with low (three items) and high cognitive load (six items). Using electrocardiography, HRV was recorded and the LF/HF ratio was extracted for mediation analyses. Path analysis revealed that cardiorespiratory fitness was significantly associated with accuracy on high cognitive load trials (β = 0.19,p = 0.035), but not on trials with low cognitive load. Perceived levels of chronic stress failed to show a significant association with working memory maintenance, independently of cognitive load. The pattern of results remained unchanged after introduction of HRV as a mediator (β = 0.18,p = 0.045). In conclusion, higher cardiorespiratory fitness is associated with better maintenance of verbal information in working memory. However, this association cannot be explained by vagal influences on memory processing driven by the autonomic nervous system.
Acute regulation of erythropoietin via lower body negative pressure: Influence of sex and age
Authors: Diaz‐Canestro Candela , Sehgal Arshia , Montero David 
Published: January 2023

The regulation of erythropoiesis via hemodynamic stimuli such as reduced central blood volume (CBV) remains uncertain in women and elderly individuals. This study assessed the acute effects of lower body negative pressure (LBNP) on key endocrine biomarkers regulating erythropoiesis, that is, erythropoietin (EPO) and copeptin, in young and older women and men (n = 87). Transthoracic echocardiography and hemodynamics were assessed throughout incremental LBNP levels for 1 hour, or until presyncope, with established methods. Venous blood samples were collected at baseline and immediately after termination of the orthostatic tolerance (OT) test for subsequent hormone analyses. The average age of young women and men (33.1 ± 6.0 vs. 29.5 ± 6.9 yr) and older women and men (63.8 ± 8.0 vs. 65.3 ± 8.9 yr) as well as their physical activity levels were matched within each age and sex group. CBV, as determined by right atrial volume, was reduced in all individuals at the end of the OT test (p < 0.001). The average OT time ranged from 50.1 to 58.1 min in all individuals. LBNP increased circulating EPO in young women (p = 0.023) but not in young men or older individuals. Copeptin was increased in all individuals with LBNP but was exclusively associated with EPO in men (r = 0.39,p = 0.013). The present study indicates that the acute hemodynamic regulation of EPO production is both sex‐ and age‐dependent.
Ultrasonographic comparison of the intermediate patellar ligament in warmbloods versus quarter horses
Authors: Cannon Joanna K. , Ellis Katherine L. 
Published: January 2023

AbstractStriations are present on ultrasonography of the intermediate (middle) patellar ligament in the transverse plane, which can be confused with tears. Comparison to the contralateral limb is often performed to help differentiate anatomic variation from pathologic change. The purposes of this prospective, observational study were to describe the striation patterns in Warmbloods and Quarter Horses, determine if these patterns are bilaterally symmetrical, and compare striation characteristics between Warmbloods and Quarter Horses. The intermediate patellar ligaments of six Warmblood horses and six Quarter horses, free from clinical signs of hindlimb lameness and in full work, were examined ultrasonographically. Striation pattern, striation number, and the transverse‐sectional areas for intermediate patellar ligaments were compared between Warmbloods and Quarter horses. Striation patterns were also compared for the left and right limbs of each horse. A significant difference between breeds was identified at the mid‐portion of the intermediate patellar ligament when both left and right ligaments were included (P = 0.02) and when comparing the right intermediate patellar ligament (P = 0.02). There were no other significant breed differences, and a parallel pattern was the most common pattern type. Two‐thirds of the horses in this study had bilaterally symmetrical patterns within the distal aspect of their intermediate patellar ligaments, while one‐third of the population were asymmetric. These results show that comparison of the contralateral limb during ultrasonography to determine if changes within the distal aspect of the intermediate patellar ligament are normal striations versus tears may lead to misdiagnosis in one‐third of horses, regardless of breed. Other signs of pathology on ultrasonography should be used instead.
Characterisation of Czech arable weed communities according to management and production area considering the prevalence of herbicide‐resistant species
Authors: Kolářová Michaela , Piskáčková Theresa A. Reinhardt , Tyšer Luděk , Hoová Thien T. 
Published: January 2023

AbstractHerbicide resistance is a widespread issue that impacts management of conventional farms, but also has ramifications for the weed community assembly; it is therefore important to see how these species factor into the weed community assembly of farms throughout the countryside. This research analysed species richness and community diversity in 98 field relevés from 48 organic and 50 conventional farms evenly distributed between two major production regions of the Czech Republic and then evaluated the incidence of species which have been reported resistant in the Czech Republic and its neighbouring countries. Farms were selected independently of any acknowledged resistant species. Out of 164 species found in this survey, only eight species have had herbicide‐resistant biotypes reported in the Czech Republic, while a total of 19 species had herbicide‐resistant biotypes reported in neighbouring countries. Species with recorded resistance to PSII inhibitors in the Czech Republic tended to be found together and were mostly associated with the beet production region, characterised by low altitude: Amaranthus retroflexus, Chenopodium album, Echinochloa crus‐galli and Solanum nigrum. Species with reported resistance to ALS and ACCase‐inhibiting herbicides were not clearly associated with a particular region or farming type. Of the species which have had reported herbicide resistance in the neighbouring countries, several were found in conventional fields within the growing season and we recommend immediate screening for herbicide resistance in these species and more diligent action in management according to anti‐resistance strategies: Bromus sterilis resistant to ACCase‐inhibiting herbicides, A. retroflexus resistant to ALS‐inhibiting herbicides or Avena fatua resistant to ACCase and ALS‐inhibiting herbicides. This work is unique in that it is evaluating weed species diversity in organic and conventional farms and using the context to frame the prevalence of high‐risk herbicide‐resistant species; thereby putting the potential incidence of herbicide resistance into perspective at the landscape level.
Use of hyperspectral imaging to predict healing of diabetic foot ulceration
Authors: Kounas Konstantinos , Dinh Thanh , Riemer Kevin , Rosenblum Barry I. , Veves Aristidis , Giurini John M. 
Published: January 2023

AbstractOur main objective was to validate that hyperspectral imaging via a new portable camera carries the potential to provide a reliable clinical biomarker that can predict DFU healing. We recruited patients with diabetic foot ulceration (DFU) without peripheral arterial disease, infection or other serious illness. Using an hyperspectral imaging (HSI) apparatus, post‐debridement hyperspectral images were taken evaluating the ulcer size, periwound oxyhemoglobin (OxyHb), deoxyhemoglobin level (DeoxyHb) and oxygen saturation (O2Sat) for four consecutive visits. Twenty‐seven patients were followed, out of whom seven healed their DFU while the remaining 20 failed to heal their DFU. The average time between each visit was 3 weeks. Binary logistic regression of healers versus non‐healers on Visit 1 oxyHb and on Visit 2 showed a significant inverse association, OR = 0.85 (95% CI: 0.73–0.98, p < 0.001). An inverse correlation was observed between the Visit 1 oxyHb and the percentage of ulcer size reduction between Visit 1 and Visit 4 (r = −0.46, p = 0.02) and between the Visit 2 oxyHb and the percentage of ulcer size reduction between Visits 2 and 4 (r = −0.65, p = 0.001). Using oxyHb 50 as the cut‐off point to predict DFU complete healing, Visit 1 oxyHb measurement provided 85% sensitivity, 70% specificity, 50% positive predictive value and 93% negative predictive value. For Visit 2, oxyHb had 85% sensitivity, 85% specificity, 66% positive predictive value and 94% negative predictive value. We conclude that this preliminary study, which involved a relatively small number of patients, indicates that hyperspectral imaging is a simple exam that can easily be added to daily clinical practice and has the potential to provide useful information regarding the healing potential of DFU over a short period of time.
Reporting quality and risk of bias in JBI systematic reviews evaluating the effectiveness of interventions: a methodological review protocol
Authors: Grammatopoulos Tahlia , Hunter Jeremy W.S. , Munn Zachary , Stone Jennifer C. , Barker Timothy H. 
Published: January 2023

Objective:
The objective of this methodological review is to evaluate the adherence of systematic reviews of effectiveness published in JBI Evidence Synthesis to reporting guidelines and methodological quality.

Introduction:
Systematic reviews of effectiveness are essential tools for health practitioners and policymakers. The Preferred Reporting Items of Systematic Reviews (PRISMA) 2020 guidelines and the Risk of Bias in Systematic Reviews (ROBIS) tool are used to ensure maintenance of high reporting standards and methodological quality, respectively. This review will utilize these tools to identify strengths and shortfalls in the reporting quality of JBI systematic reviews of effectiveness.

Inclusion criteria:
This review will include the 20 most recent systematic reviews of effectiveness published in JBI Evidence Synthesis (formerly the JBI Database of Systematic Reviews and Implementation Reports).

Methods:
This review will search MEDLINE (PubMed) for effectiveness reviews published in JBI Evidence Synthesis. Abstract and full-text screening will be performed by 2 independent reviewers and the most recent 20 studies will be selected for inclusion. Data regarding adherence to PRISMA 2020 and ROBIS will be extracted by 2 independent reviewers. Data will be presented descriptively with tables and synthesized narratively.
Electroencephalogram Experimentation to Understand Creativity of Mechanical Engineering Students
Authors: Ahad Md Tanvir , Hartog Tess , Alhashim Amin G. , Marshall Megan , Siddique Zahed 
Published: January 2023

AbstractElectroencephalogram (EEG) alpha power (8–13 Hz) is a characteristic of various creative task conditions and is involved in creative ideation. Alpha power varies as a function of creativity-related task demands. This study investigated the event-related potentials (ERPs), alpha power activation, and potential machine learning (ML) to classify the neural responses of engineering students involved with creativity task. All participants performed a modified alternate uses task (AUT), in which participants categorized functions (or uses) for everyday objects as either creative, nonsense, or common. At first, this study investigated the fundamental ERPs over central and parietooccipital temporal areas. The bio-responses to understand creativity in engineering students demonstrates that nonsensical and creative stimuli elicit larger N400 amplitudes (−1.107 mV and −0.755 mV, respectively) than common uses (0.0859 mV) on the 300–500 ms window. N400 effect was observed on 300–500 ms window from the grand average waveforms of each electrode of interest. ANOVA analysis identified a significant main effect: decreased alpha power during creative ideation, especially over (O1/2, P7/8) parietooccipital temporal area. Machine learning is used to classify the specific temporal area data’s neural responses (creative, nonsense, and common). A k-nearest neighbors (kNN) classifier was used, and results were evaluated in terms of accuracy, precision, recall, and F1- score using the collected datasets from the participants. With an overall 99.92% accuracy and area under the curve at 0.9995, the kNN classifier successfully classified the participants’ neural responses. These results have great potential for broader adaptation of machine learning techniques in creativity research.
The Effect of McGill Core Stability Training on Movement Patterns, Shooting Accuracy, and Throwing Performance in Male Basketball Players: A Randomized Controlled Trial
Authors: Hessam Masumeh , Fathalipour Koroush , Behdarvandan Amin , Goharpey Shahin 
Published: January 2023

Context: Core stability training has been recommended as a vital element in improving movement’s pattern and athletic performance. The main objective of this study was to investigate the effect of 12-week McGill core stability training on movement patterns, shooting accuracy, and throwing performance. Design: Randomized controlled clinical trial. Setting: University research laboratory. Methods: Forty male basketball players were randomly assigned to experimental and control groups. The experimental group completed 12-week McGill core stability training, while the control group completed routine exercise training. Patterns of functional movements was measured through functional movement screen (FMS), shooting accuracy measured by static 3-point shooting (S3P) and dynamic 60-second 3-point shooting test, and throwing performance measured by Functional Throwing Performance Index. Results: Comparison revealed that regardless of received training, after 12 weeks both groups showed significant improvement in all outcome measures. However, experimental group had significantly higher post test scores in FMS (P = .02), S3P (P = .007), and dynamic 60-second 3-point shooting test (P = .01). For Functional Throwing Performance Index, there was no group differences (P = .96). The results of follow-up assessments showed for all measurements including FMS (P = .03), S3P (P = .004), dynamic 60-second 3-point shooting test (P < .001), and Functional Throwing Performance Index (P = .005); experimental group had higher scores than the control group. Conclusions: According to the results, implementing McGill core stability training in basketball routine training would be advisable since significant improvement can be obtained in the measured parameters.