bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avascular necrosis of the femoral head in a cynomolgus macaque (Macaca fascicularis)
Authors: Frankel Jeffrey S. , Gardiner Kristin L. , Brice Angela K. , Hagan Lisa , Manzi Timothy J. , Makaron Leah 
Published: May 2023

AbstractA cynomolgus macaque presented with right hindlimb lameness as well as crepitus and decreased passive range of motion of the right coxal joint. Radiography and histopathology were consistent with avascular necrosis of the femoral head. This case is the first published report of this condition in a cynomolgus macaque.
Dissecting cell‐type‐specific pathways in medial entorhinal cortical‐hippocampal network for episodic memory
Authors: Osanai Hisayuki , Nair Indrajith R. , Kitamura Takashi 
Published: May 2023

AbstractEpisodic memory, which refers to our ability to encode and recall past events, is essential to our daily lives. Previous research has established that both the entorhinal cortex (EC) and hippocampus (HPC) play a crucial role in the formation and retrieval of episodic memories. However, to understand neural circuit mechanisms behind these processes, it has become necessary to monitor and manipulate the neural activity in a cell‐type‐specific manner with high temporal precision during memory formation, consolidation, and retrieval in the EC‐HPC networks. Recent studies using cell‐type‐specific labeling, monitoring, and manipulation have demonstrated that medial EC (MEC) contains multiple excitatory neurons that have differential molecular markers, physiological properties, and anatomical features. In this review, we will comprehensively examine the complementary roles of superficial layers of neurons (II and III) and the roles of deeper layers (V and VI) in episodic memory formation and recall based on these recent findings.image
Global challenges in access to diagnostics and treatment for neuroendocrine tumor (NET) patients
Authors: Dureja Sugandha , McDonnell Mark , Van Genechten Dirk , Bouvier Catherine , Kolarova Teodora , O'Toole Dermot , Singh Harjit , Chen Jie , Howe James , Singh Simron , Rodien‐Louw Christine , Leyden Simone , Gellerman Elyse , Herman Jackie , Pavel Marianne ,   International Neuroendocrine Cancer Alliance (INCA)
Published: May 2023

AbstractSCAN, an online survey, measured access to diagnosis, treatments and monitoring of neuroendocrine tumor (NET) patients globally. Between September and November 2019, NET patients and healthcare professionals (HCPs) completed an online, semi‐standardized survey with 54 patient questions and 33 HCP questions. A total of 2359 patients with NETs and 436 HCPs responded. Misdiagnosis was common (44% [1043/2359]). Mean time to diagnosis was 4.8 years (standard deviation [SD], 6.2). Compared with global figures (60% [1407/2359]), the availability of 68Ga‐DOTA positron emission tomography (PET)/computed tomography (CT) was significantly lower in Asia (45% [126/280]) and higher in Oceania (86% [171/200]). HCPs reported that 68Ga‐DOTA PET/CT was free/affordable to fewer patients in Emerging and Developing Economies (EDE) than Advanced Economies (AE; 17% [26/150] and 59% [84/142], respectively). Compared with global data (52% [1234/2359]), patient‐reported availability of peptide receptor radionuclide therapy (PRRT) was significantly lower in Asia (31% [88/280]) and higher in Oceania (61% [122/200]). Significant differences were observed in average annual NET specialist costs between AE and EDE ($1081 and $2915, respectively). Compared with AE, patients in EDE traveled further for NET specialists (1032 [SD, 1578] and 181 [SD, 496] km, respectively). Patients and HCPs both recommended referral to HCPs that were more knowledgeable in the field of NETs and had better access to NET experts/specialist centers. National care pathways, enhancing HCP NET knowledge and ensuring effective diagnostics and access to appropriate treatments are crucial to improving patient survival and NET care worldwide.
Toxic medications in Charcot–Marie–Tooth patients: A systematic review
Authors: Cavaletti Guido , Forsey Katherine , Alberti Paola 
Published: May 2023

AbstractBackground and AimsSeveral widely used medications, with a relevant efficacy profile, are toxic to the peripheral nervous system and an even larger number of agents are suspected to be neurotoxic. There are concerns about the use of these drugs in patients with Charcot–Marie–Tooth disease (CMT), a hereditary motor and sensory neuropathy. This review provides evidence‐based updated recommendations on this clinically relevant topic.MethodsA systematic review of the available studies/reports written in English was performed from July to September 2022 including in the search string all reported putative neurotoxic drugs.ResultsThe results of our systematic review provide evidence‐based support for the statement that use of vincristine, and possibly paclitaxel, can occasionally induce an atypical, and more severe, course of drug‐related peripheral neurotoxicity in CMT patients. It is therefore reasonable to recommend caution in the use of these compounds in CMT patients. However, no convincing evidence for a similar recommendation could be found for all other drugs.InterpretationIt is important that patients with CMT are not denied effective treatments that may prolong life expectancy for cancer or improve their health status if affected by non‐oncological diseases. Accurate monitoring of peripheral nerve function in CMT patients treated with any neurotoxic agent remains mandatory to detect the earliest signs of neuropathy worsening and atypical clinical courses. Neurologists monitoring CMT patients as part of their normal care package or for natural history studies should keep detailed records of exposures to neurotoxic medications and support reporting of accelerated neuropathy progression if observed.
Clinical features of a family with late‐onset distal hereditary motor neuropathy harboring p.Pro39Leu variant of HSPB1
Authors: Naruse Hiroya , Okubo So , Sudo Atsushi , Mitsui Jun , Mikata Takashi , Ishiura Hiroyuki , Morishita Shinichi , Tsuji Shoji , Toda Tatsushi 
Published: May 2023

AbstractBackground and AimsPathogenic variants of HSPB1, the gene encoding the small heat shock protein 27, have been reported to cause autosomal dominant distal hereditary motor neuropathy (dHMN) type II and autosomal dominant Charcot–Marie‐Tooth (CMT) disease with minimal sensory involvement (CMT2F). This study aimed to describe the clinical features of patients in a family with late‐onset dHMN carrying the Pro39Leu variant of HSPB1.MethodsWhole‐exome sequence analysis identified a heterozygous pathogenic variant (Pro39Leu) of HSPB1 in the proband. The presence of the HSPB1 Pro39Leu variant in two affected individuals was confirmed using direct nucleotide sequence analysis.ResultsBoth patients exhibited distal muscle weakness with lower extremity predominance and no obvious sensory deficits, leading to a clinical diagnosis of late‐onset dHMN. Nerve conduction studies (NCSs) revealed a subclinical complication of sensory disturbance in one of the patients. The clinical and electrophysiological findings of patients with the HSPB1 Pro39Leu variant in this study and previous reports are summarized.InterpretationThis study suggests that the clinical spectrum of patients carrying HSPB1 Pro39Leu variants, especially the disease onset, might be broader than expected, and HSPB1 variants should be considered in patients diagnosed with late‐onset dHMN. Furthermore, patients with dHMN may have concomitant sensory deficits that should be evaluated using NCSs.
Neuroimaging meta‐analysis of brain mechanisms of the association between orofacial pain and mastication
Authors: Chen Ta‐Chung , Lin Chia‐Shu 
Published: May 2023

AbstractBackgroundTemporomandibular disorders (TMD) are characterized by pain and impaired masticatory functions. The Integrated Pain Adaptation Model (IPAM) predicts that alterations in motor activity may be associated with increased pain in some individuals. The IPAM highlights the diversity of patients' responses to orofacial pain and suggests that such diversity is related to the sensorimotor network of the brain. It remains unclear whether the pattern of brain activation reflects the diversity of patients' responses underlying the association between mastication and orofacial pain.ObjectiveThis meta‐analysis aims to compare the spatial pattern of brain activation, as the primary outcome of neuroimaging studies, between studies of mastication (i.e. Study 1: mastication of healthy adults) and studies of orofacial pain (i.e. Study 2: muscle pain in healthy adults and Study 3: noxious stimulation of the masticatory system in TMD patients).MethodsNeuroimaging meta‐analyses were conducted for two groups of studies: (a) mastication of healthy adults (Study 1, 10 studies) and (b) orofacial pain (7 studies), including muscle pain in healthy adults (Study 2) and noxious stimulation of the masticatory system in TMD patients (Study 3). Consistent loci of brain activation were synthesized using Activation Likelihood Estimation (ALE) with an initial cluster‐forming threshold (p < .05) and a threshold of cluster size (p < .05, familywise error‐corrected).ResultsThe orofacial pain studies have shown consistent activation in pain‐related regions, including the anterior cingulate cortex and the anterior insula (AIns). A conjunctional analysis of mastication and orofacial pain studies showed joint activation at the left AIns, the left primary motor cortex and the right primary somatosensory cortex.ConclusionThe meta‐analytical evidence suggests that the AIns, as a key region in pain, interoception and salience processing, contributes to the pain‐mastication association. These findings reveal an additional neural mechanism of the diversity of patients' responses underlying the association between mastication and orofacial pain.
Consistency amongst pairs: How consistent are child co‐witnesses with one another?
Authors: Deck Sarah L. , Brubacher Sonja P. , Dickinson Jason J. , Powell Martine B. 
Published: May 2023

AbstractPurposeWhen multiple children are asked about the same event, the consistency of their reports may be used as a heuristic for credibility. Little research has considered how consistent child co‐witnesses are likely to be. In this study, we explored how likely child co‐witnesses were to report the same details from a mutually experienced event.MethodsPairs of children participated in an educational science event during which the target attempted to coax the children into breaking preestablished rules for the session (i.e., commit transgressions). Children were individually interviewed about their experience on two subsequent occasions.ResultsCo‐witnesses tended to be quite inconsistent: 32%–55% of all details recalled were only mentioned by one co‐witness. Various factors were associated with co‐witness consistency, including delay before the interview, centrality of details recalled, and children's age and forthcomingness.ConclusionsThe findings indicate that inconsistency between co‐witnesses reflects a natural memory phenomenon, and that practitioners should be cautious of using co‐witness consistency as an indicator of credibility.
Effects of the ridge‐and‐runnel system on macrofaunal spatial distribution on a macrotidal sandy beach in the Brazilian Amazon coast
Authors: Cardoso Edma Mayara Pereira , Petracco Marcelo , Santos Thuareag , Venekey Virag , Aviz Daiane 
Published: May 2023

AbstractRidge‐and‐runnel systems are common morphological features across the intertidal zone of dissipative macrotidal beaches. However, these systems have often been overlooked by macrofaunal zonation studies. The present study investigated the effects of this system on the spatial distribution of the macrofaunal community on an Amazonian macrotidal sandy beach. Samples (macrobenthos and sediments) were collected at seven equidistant levels (50 m apart) from the high tide water mark to the swash zone, in two different areas: (1) with and (2) without ridge‐and‐runnel systems. The results showed a significant increase in macrofaunal abundance and richness in area with runnels, associated with muddier sediment and higher organic content. The macrofauna in the runnels, both in upper‐intertidal and lower‐intertidal zones, had higher density and richness than that in the sandbars. There was no difference between tidal levels in area 2, although we observed an increasing tendency of abundance and richness towards the low tide line. Taxonomic composition and trophic groups also differed between areas, with predominance of species that are typical of sandy‐mud substrate and higher participation of nonselective deposit feeders in area 1. Predatory species typical of sandy substrates prevailed in area 2. These findings add knowledge to sandy beach ecology and indicate the importance of including aspects of habitat complexity in both across‐ and alongshore macrofaunal distribution studies.
Variations in mechanical stiffness alter microvascular sprouting and stability in a PEG hydrogel model of idiopathic pulmonary fibrosis
Authors: Leonard‐Duke Julie , Bruce Anthony C. , Peirce Shayn M. , Taite Lakeshia J. 
Published: May 2023

AbstractObjectiveMicrovascular remodeling is governed by biomechanical and biochemical cues which are dysregulated in idiopathic pulmonary fibrosis. Understanding how these cues impact endothelial cell‐pericyte interactions necessitates a model system in which both variables can be independently and reproducibly modulated. In this study we develop a tunable hydrogel‐based angiogenesis assay to study how varying angiogenic growth factors and environmental stiffness affect sprouting and vessel organization.MethodsLungs harvested from mice were cut into 1 mm long segments then cultured on hydrogels having one of seven possible stiffness and growth factor combinations. Time course, brightfield, and immunofluorescence imaging were used to observe and quantify sprout formation.ResultsOur assay was able to support angiogenesis in a comparable manner to Matrigel in soft 2 kPa gels while enabling tunability to study the effects of stiffness on sprout formation. Matrigel and 2 kPa groups contained significantly more samples with sprouts when compared to the stiffer 10 and 20 kPa gels. Growth factor treatment did not have as obvious an effect, although the 20 kPa PDGF + FGF‐treated group had significantly longer vessels than the vascular endothelial growth factor‐treated group.ConclusionsWe have developed a novel, tunable hydrogel assay for the creation of lung explant vessel organoids which can be modulated to study the impact of specific environmental cues on vessel formation and maturation.
A critical examination of epistemological congruence between intersectionality and feminist poststructuralism: Toward an integrated framework for health research
Authors: Willett Andrea , Etowa Josephine 
Published: May 2023

AbstractThe theoretical perspectives of intersectionality and poststructuralism have contributed meaningfully to advancing issues of social injustice within the realm of women's health research. However, the question of whether the two approaches are epistemologically commensurate has been at the heart of a polarized debate within third‐ and fourth‐wave feminist literature in recent years. In this paper, we draw on the extant literature to explore existing dilemmas within this debate and critically reflect on points of epistemological tension and congruence between the two perspectives. It will be demonstrated that intersectionality and poststructuralism, especially feminist poststructuralism, represent concordant theoretical perspectives and a synthesized theoretical framework for application in qualitative research into women's health will be proposed. We argue that an intersectional feminist poststructuralist framework contributes to a deepened analysis of women's disparate healthcare experiences, and the social mechanisms, power relations, and discourses that mediate these experiences, while offering avenues for advocacy and political praxis on a multitude of levels.
Physicians and nurses view on their roles in communication and collaboration with families: A qualitative study
Authors: Woldring Josien M. , Gans Rijk O. B. , Paans Wolter , Luttik Marie Louise 
Published: May 2023

AbstractBackgroundFamilies are introduced as new partners in interprofessional communication and collaboration during hospitalisation of an adult patient. Their introduction into the healthcare team has consequences for the roles and responsibilities of all healthcare professionals. Role clarification is thus needed to create optimal communication and collaboration with families.AimTo gain insight into how physicians and nurses view their own roles and each other's roles in communication and collaboration with families in the care of adult patients.MethodsA qualitative interpretive interview design was used. Fourteen semi‐structured interviews, with seven physicians and seven nurses, were conducted. Data were analysed according to the steps of thematic analysis. For the study design and analysis of the results, the guidelines of the consolidated criteria for reporting qualitative studies (COREQ) were followed. The ethical committee of the University Medical Center Groningen approved the study protocol (research number 202100640).FindingsThematic analysis resulted in three themes, each consisting of two or three code groups. Two themes “building a relationship” and “sharing information” were described as roles that both nurses and physicians share regarding communication and collaboration with families. The role expectations differed between physicians and nurses, but these differences were not discussed with each other. The theme “providing support to family” was regarded a nurse‐specific role by both professions.ConclusionPhysicians and nurses see a role for themselves and each other in communication and collaboration with families. However, the division of roles and expectations thereof are different, overlapping, and unclear. To optimise the role and position of family during hospital care, clarification and division of the roles between physicians and nurses in this partnership is necessary.
The RLCK subfamily VII‐4 controls pattern‐triggered immunity and basal resistance to bacterial and fungal pathogens in rice
Authors: Jalilian Ahmad , Bagheri Abdolreza , Chalvon Véronique , Meusnier Isabelle , Kroj Thomas , Kakhki Amin Mirshamsi 
Published: May 2023

SUMMARYReceptor‐like cytoplasmic kinases (RLCKs) mediate the intracellular signaling downstream of pattern‐recognition receptors (PRRs). Several RLCKs from subfamily VII of rice (Oryza sativa) have important roles in plant immunity, but the role of RLCK VII‐4 in pattern‐triggered immune (PTI) signaling and resistance to pathogens has not yet been investigated. Here, we generated by multiplex clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated protein 9‐mediated genome editing rice sextuple mutant lines where the entire RLCK VII‐4 subfamily is inactivated and then analyzed the resulting lines for their response to chitin and flg22 and for their immunity to Xanthomonas oryzae pv. oryzae (Xoo) and Magnaporthe oryzae. Analysis of the rlckvii‐4 mutants revealed that they have an impaired reactive oxygen system burst and reduced defense gene expression in response to flg22 and chitin. This indicates that members of the rice RLCK VII‐4 subfamily are required for immune signaling downstream of multiple PRRs. Furthermore, we found that the rice RLCK VII‐4 subfamily is important for chitin‐induced callose deposition and mitogen‐activated protein kinase activation and that it is crucial for basal resistance against Xoo and M. oryzae pathogens. This establishes that the RLCK VII‐4 subfamily has critical functions in the regulation of multiple PTI pathways in rice and opens the way for deciphering the precise role of its members in the control of rice PTI.
Xenotransplantation literature update March 2021–March 2023
Authors: Kamberi Shani , Meier Raphael P.H. 
Published: May 2023

AbstractAfter a significant hiatus imposed by the COVID‐19 pandemic, we hereby restart Xenotransplantation literature updates. With the recently performed clinical xenotransplantation cases and the much‐heightened interest in the field, we have determined that this is an optimal time to reinstate this section. There has been an invigorated focus on unique challenges posed by pig‐to‐human xenotransplantation, and specific attention will be given to this aspect. In this issue, we aimed to cover the gap and compiled the most relevant publications from March 2021 to March 2023.
Positive scalar curvature and homology cobordism invariants
Authors: Konno Hokuto , Taniguchi Masaki 
Published: May 2023

AbstractWe give an obstruction to positive scalar curvature metrics on 4‐manifolds with the homology described in terms of homology cobordism invariants from Seiberg–Witten theory. The main tool of the proof is a relative Bauer–Furuta‐type invariant on a periodic‐end 4‐manifold.
A Novel Approach to Line Clipping Against a Rectangular Window
Authors: Yu H. Y. , He Y. J. , Zhang W. J. 
Published: May 2023

Abstract
Line clipping against a rectangular window is a fundamental problem in computer graphics. A robust and fast algorithm is needed not only for the traditional graphics pipeline but also for new applications, including web maps, nanomaterials, and sensor measurements. In this paper, we present a novel approach, which is based on the idea of combining the geometric and algebraic approaches. In particular, the proposed approach first decomposes a 2D line clipping problem into a set of 1D clipping problems, and then solves the 1D clipping problem by the comparison (i.e., &gt;, &lt;, and =) operation on the coordinate value of the projected points on one dimension only. Both theoretical analysis and experimental tests were conducted to demonstrate the improved robustness (for degenerated cases) and computational efficiency of the proposed approach.
Hierarchical Automatic Multilayer Power Plane Generation With Genetic Optimization and Multilayer Perceptron
Authors: Liao Haiguang , Patil Vinay , Dong Xuliang , Shanbhag Devika , Fallon Elias , Hogan Taylor , Spasojevic Mirko , Burak Kara Levent 
Published: May 2023

Abstract
We present an automatic multilayer power plane generation method to accelerate the design of printed circuit boards (PCB). In PCB design, while automatic solvers have been developed to predict important indicators such as the IR-drop, power integrity, and signal integrity, the generation of the power plane itself still largely relies on laborious manual methods. Our automatic power plane generation approach is based on genetic optimization combined with a multilayer perceptron (MLP) and is able to automatically generate power planes across a diverse set of problems with varying levels of difficulty. Our method GOMLP consists of an outer loop genetic optimizer (GO) and an inner loop MLP that generate power planes automatically. The critical elements of our approach include contour detection, feature expansion, and a distance measure to enable island-minimizing complex power plane generation. We compare our approach to a baseline solution based on A*. The A* method consisting of a sequential island generation and merging process which can produce less than ideal solutions. Our experimental results show that on single layer power plane problems, our method outperforms A* in 71% of the problems with varying levels of board layout difficulty. We further describe H-GOMLP, which extends GOMLP to multilayer power plane problems using hierarchical clustering and net similarities based on the Hausdorff distance.