bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frontal Sinus Mucosa Bacteriological Features: Evaluation after Unintentional Opening in Neurosurgery
Authors: Sato Hiroki , Ooigawa Hidetoshi , Suzuki Kaima , Yanagawa Taro , Lepic Milan , Otsuka Munehiro , Fushihara Goji , Kurita Hiroki 
Published: January 2023

Abstract
Objectives The bacteriological features of the frontal sinus mucosa may impose significant complications in neurosurgery, when breached unintentionally. This study aimed to investigate the bacterial flora in patients undergoing frontal craniotomy for cerebrovascular substrate surgery.
Design This is a single-center prospective study.
Setting When mucosal laceration occurred, the patients underwent frontal sinus reconstruction with mucosa reconstruction, preserving the nasofrontal duct.
Participants We enrolled eight consecutive patients who underwent bifrontal craniotomy associated with frontal sinus mucosa laceration.
Main Outcome Measures A portion of the mucosa was extracted during the reconstructive procedure and was sent for microbiological analysis.
Results None of the patients presented with the bacterial flora in the mucosal cultures. No patient experienced postoperative cerebrospinal fluid leakage or meningitis. One patient with a clinical history of chronic maxillary sinusitis presented with a subcutaneous abscess around the forehead at 9 months postoperatively. The patient rapidly recovered after receiving oral administration of antibiotics.
Conclusions Our findings demonstrated that the frontal sinuses were maintained in an aseptic environment in all cases. The results may encourage the development and wider use of transfrontal sinus approaches.
Hexafluoroisopropanol-Induced Facial Selectivity in a Hindered Diels–Alder Reaction
Authors: Kornfilt David J. P. , Chamberlain Brian T. , Wagner Florence F. , Chataigner Isabelle , Spezia Riccardo 
Published: January 2023

AbstractBRD4780 is a small molecule that can selectively clear mutant MUC1-fs protein in mucin kidney disease models. Prior syntheses of BRD4780 were unsuitable for preparation on large scale. In this manuscript, HFIP is described as a unique solvent that allowed the key Diels–Alder reaction to proceed with >20:1 endo diastereoselectivity, enabling the kg-scale preparation of BRD4780 for further studies.
Single-Center Experience of Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary Hypertension: The Results from the Tabriz University Medical Sciences (TUMS) CTEPH Program
Authors: Parvizi Rezayat , Bilehjani Eisa , Mahmoudian Babak , Koohi Ata , Shojaan Hooriah , Ansarin Khalil , Rashidi Farid 
Published: January 2023

Abstract
Introduction Pulmonary endarterectomy (PEA) remains the preferred and potentially curative option for patients with chronic thromboembolic pulmonary hypertension (CTEPH). This study aimed to report the results of PEA for CTEPH in a tertiary center in Tabriz, Iran.
Methods We analyzed the results of 42 CTEPH patients undergoing PEA, who were enrolled in the Tabriz University of Medical Sciences (TUMS-CTEPH) from January 2016 to October 2020. The main outcome measures included the New York Heart Association (NYHA) functional classification, the 6-Minute Walk Distance, hemodynamic measures in right heart catheterization, morbidity, and mortality.
Results There was a significant improvement in the NYHA function class (2.6 ± 0.5 vs 1.1 ± 0.34), mean pulmonary arterial pressure (47.1 ± 13 vs 27.9 ± 8 mm Hg), cardiac output (4.3 ± 1.06 vs 5.9 ± 1.2 L/min), and pulmonary vascular resistance (709.4 ± 297.5 vs 214 ± 77 dyn s/cm5). Fifteen patients (35%) developed complications. The most common complication (10 [23%]) was reperfusion injury. Also, postsurgical mortality was 4% during hospital admission and 1-year follow-up.
Conclusion This is the first single-center report of PEA from Iran. Post-PEA and 1-year survival were acceptable as a referral center. PEA can be performed safe with low mortality. Greater awareness of PEA and patients' access to experienced CTEPH centers are important issues.
Implementation of Eye-Tracking Technology to Monitor Clinician Fatigue in Routine Clinical Care: A Feasibility Study
Authors: Kadhim Bashar , Khairat Saif , Li Fangyong , Gross Isabel T. , Nath Bidisha , Hauser Ronald G. , Melnick Edward R. 
Published: January 2023

Abstract
Background Physician fatigue increases the likelihood of medical errors. Eye-tracking technology offers an unobtrusive and objective way to measure fatigue but has only been implemented in controlled settings.
Objective Our objective was to determine the feasibility of capturing physiological indicators of fatigue using eye-tracking technology in a real-world clinical setting.
Methods A mixed-methods feasibility study was performed in a convenience sample of clinicians practicing in an urban, academic emergency department from November 11 to December 15, 2021. Outcomes included fatigue assessed at the beginning and end of each shift via eye-tracking (with low scores indicating greater fatigue) and self-report.
Results Among 15 participants, self-reported fatigue and task load increased from the beginning to the end of their shift (fatigue visual analog scale [FVAS] 3.7–4.6, p = 0.04; physician task load [PTL] 97.7–154.3, p = 0.01). It was feasible to collect eye-tracking data at a fixed computer workstation with twice daily calibration and 61% capture of reliable data when the clinician was working at the study computer. Eye-tracking metrics did not change significantly from the beginning to the end of the shift. Eye metric fatigue score was associated with the change in PTL score (r 0.59, p = 0.02) but not FVAS. This association persisted after adjusting for age, gender, and role, with every 10-point increase in PTL, there was a 0.02-point increase in fatigue score (p = 0.04).
Conclusion It is unclear whether the inability to detect fatigue via eye-tracking in routine clinical care was due to confounding factors, the technology, study design, sample size, or an absence of physiological fatigue. Further research and advances in functionality are needed to determine the eye-tracking technology's role in measuring clinician fatigue in routine care.
Robotic-Assisted Laparoscopic Complete Mesocolic Excision
Authors: Sahin Inci , Baca Bilgi 
Published: January 2023

AbstractComplete mesocolic excision (CME) with central vascular ligation is a relatively new technique in the surgical treatment of right-sided colon cancer. Although the technique was originally designed for open surgery, minimally invasive CME has quickly been embraced by colorectal surgeons. Robotic-assisted laparoscopic surgery has some certain advantages over open and standard laparoscopic surgery, and is increasingly utilized in colorectal surgery. In this review, the technical aspects and outcomes of robotic-assisted laparoscopic complete mesocolic excision will be described.
Patients With Significant Medical Comorbidities May Benefit from Unicompartmental Knee Arthroplasty Over Total Knee Arthroplasty
Authors: Pascual-Leone Nicolas , Sloan Matthew , Shah Vivek M. , Sheth Neil P. 
Published: January 2023

AbstractMany studies have compared outcomes in total knee arthroplasty (TKA) versus unicompartmental knee arthroplasty (UKA); however, to the authors' knowledge, there is no study evaluating complication rates in patients with significant comorbidities. The purpose of this retrospective study was to compare the incidence of postoperative complications, readmission and reoperation rates, length of stay (LOS), and discharge location for patients with significant medical comorbidities undergoing TKA versus UKA. Using the NSQIP database from 2008 to 2018, patients were identified by CPT code (27447 or 27446) and admission diagnostic code of primary osteoarthritis and included in the study if they had an American Society of Anesthesia score greater than or equal to 3. Chi-square test was used to compare categorical variables and t-test for continuous variables. Multivariate regression was used to compare outcomes of interest between groups. A total of 167,054 patients were analyzed with 97.3% undergoing TKA. TKA patients had a greater overall complication rate than those undergoing UKA (p < 0.001). Readmission rates were approximately 1.5 times higher in TKA compared with UKA (p = 0.002), while no statistically significant difference was discovered in reoperation rates (p = 0.868). TKA was also associated with decreased rates of same day discharge, discharge within 24 hours of surgery, and discharge home (p < 0.001, <0.001, and <0.001, respectively). This study found an increase in complication rates, readmission rates, and LOS, along with a lower likelihood of discharge home when undergoing a TKA. These findings suggest that patients with significant medical comorbidities at baseline may benefit from UKA over TKA when anatomically indicated.
Quality of a master’s degree in education in Ecuador
Authors: Ambrós-Pallarés Alba , Puig Marta Sabariego , Moreno Concepción Fuentes 
Published: January 2023

AbstractThis study assesses the quality of a Master’s Degree in education in Ecuador, a program delivered jointly by three institutions (the Ecuadorian Ministry of Education, the National Education University of Ecuador and the University of Barcelona) from 2017 to 2019. The study adopts a multi-dimensional definition of quality that encompasses organization, teaching and trainees’ satisfaction with the value of the course for their professional development. A survey was conducted among 308 trainee teachers using an online questionnaire featuring both open and closed questions. The descriptive analysis of the variables was performed with SPSS and the qualitative information was analyzed using Nvivo12. The findings showed evidence of quality in organization, administration and teaching, in addition to trainee satisfaction with the personal and professional benefits of the course. The study concludes with recommendations for adapting the pedagogical and didactic contents of the master’s degree to the Ecuadorian context and modifying the organization of the face-to-face phase. Evidence is also offered of the value of blended learning and suggestions are made for ongoing institutional self-evaluation to ensure continued improvements and internal regulation in Ecuadorian higher education, and to further develop the government’s Good Living program.
Structural, electronic, and magnetic properties of CoFeVGe-based compounds: Experiment and theory
Authors: Kharel Parashu , Lehmann Zachary , Baker Gavin , Stuelke Lukas , Valloppilly Shah , Shand Paul M. , Lukashev Pavel V. 
Published: January 2023

We have carried out a combined theoretical and experimental investigation of both stoichiometric and nonstoichiometric CoFeVGe alloys. In particular, we have investigated CoFeVGe, Co1.25Fe0.75VGe, Co0.75Fe1.25VGe, and CoFe0.75VGe bulk alloys. Our first principles calculations suggest that all four alloys show ferromagnetic order, where CoFeVGe, Co1.25Fe0.75VGe, and Co0.75Fe1.25VGe are highly spin polarized with spin polarization values of over 80%. However, the spin polarization value of CoFe0.75VGe is only about 60%. We have synthesized all four samples using arc melting and high-vacuum annealing at 600 °C for 48 hours. The room temperature x-ray diffraction of these samples exhibits a cubic crystal structure with disorder. All the samples show single magnetic transitions at their Curie temperatures, where the Curie temperature and high field (3T) magnetization are 288 K and 42 emu/g; 305 K and 1.5 emu/g; 238 K and 39 emu/g; and 306 K and 35 emu/g for CoFeVGe, Co1.25Fe0.75VGe, Co0.75Fe1.25VGe, and CoFe0.75VGe, respectively.
Adapting the ‘First 2000 Days maternal and child healthcare framework’ in the aftermath of the COVID-19 pandemic: ensuring equity in the new world
Authors: Mendoza Diaz Antonio , Brooker Ron , Cibralic Sara , Murphy Elisabeth , Woolfenden Sue , Eapen Valsamma 
Published: January 2023

The purpose of this perspective article is to emphasise the importance of the ‘First 2000 Days’ policy of life from conception to age five, and to propose new directions in which the policy’s implementation could be extended for the benefit of children and families. The proposed approach highlights principles of responsiveness, integration, sustainability and equity, specifying initiatives that embody the kind of innovation each principle aspires to. The article also proposes innovations in data collection and linkages that would strengthen the implementation of first 2000 days policies and frameworks. This perspective proposes a framework that could improve health systems implementation of services in the first 5 years of life, by proposing a well-coordinated continuum of services with integrated physical and digital solutions. This has the potential to transform how the health system monitors and responds to children and families’ needs in the critical early years of life during and beyond the current pandemic.
HER2-driven breast cancer suppression by the JNK signaling pathway
Authors: Itah Zeynep , Chaudhry Shanzah , Raju Ponny Sithara , Aydemir Ozkan , Lee Alexandra , Cavanagh-Kyros Julie , Tournier Cathy , Muller William J. , Davis Roger J. 
Published: January 2023

The HER2
+
subtype of human breast cancer is associated with the malignant transformation of luminal ductal cells of the mammary epithelium. The sequence analysis of tumor DNA identifies loss of function mutations and deletions of the
MAP2
K4
and
MAP2
K7
genes that encode direct activators of the JUN NH
2
-terminal kinase (JNK). We report that in vitro studies of human mammary epithelial cells with CRISPR-induced mutations in the MAPK and MAP2K components of the JNK pathway caused no change in growth in 2D culture, but these mutations promoted epithelial cell proliferation in 3D culture. Analysis of gene expression signatures in 3D culture demonstrated similar changes caused by HER2 activation and JNK pathway loss. The mechanism of signal transduction cross-talk may be mediated, in part, by JNK-suppressed expression of integrin α6β4 that binds HER2 and amplifies HER2 signaling. These data suggest that HER2 activation and JNK pathway loss may synergize to promote breast cancer. To test this hypothesis, we performed in vivo studies using a mouse model of HER2
+
breast cancer with
Cre/loxP
-mediated ablation of genes encoding JNK (
Mapk8
and
Mapk9
) and the MAP2K (
Map2
k4
and
Map2
k7
) that activate JNK in mammary epithelial cells. Kaplan–Meier analysis of tumor development demonstrated that JNK pathway deficiency promotes HER2
+
-driven breast cancer. Collectively, these data identify JNK pathway genes as potential suppressors for HER2
+
breast cancer.
Direct growth of crystalline SiGe nanowires on superconducting NbTiN thin films
Authors: Wang Xuejing , Thomas Sean M , Baldwin J Kevin , Addamane Sadhvikas , Sheehan Chris , Yoo Jinkyoung 
Published: January 2023

Abstract
Novel heterostructures created by coupling one-dimensional semiconductor nanowires with a superconducting thin film show great potential toward next-generation quantum computing. Here, by growing high-crystalline SiGe nanowires on a NbTiN thin film, the resulting heterostructure exhibits Ohmic characteristics as well as a shift of the superconducting transition temperature (T
c). The structure was characterized at atomic resolution showing a sharp SiGe/NbTiN interface without atomic interdiffusion. Lattice spacing, as calculated from large-area x-ray diffraction experiments, suggests a potential preferred d-spacing matching between (200) NbTiN and (110) SiGe grains. The observed out-of-plane compressive strain within the NbTiN films coupled with SiGe nanowires explains the downward shift of the superconductivity behavior. The presented results post scientific insights toward functional heterostructures by coupling multi-dimensional materials, which could enable tunable superconductivity that benefits the quantum science applications.
AuAg nanocomposites suppress biofilm-induced inflammation in human osteoblasts
Authors: Lee Chiang-Wen , Lin Zih-Chan , Chiang Yao-Chang , Li Sin-Yu , Ciou Jyun-Jia , Liu Kuan-Wen , Lin Yu-Ching , Huang Bo-Jie , Peng Kuo-Ti , Fang Mei-Ling , Lin Tzu-En , Liao Mei-Yi , Lai Chian-Hui 
Published: January 2023

Abstract

Staphylococcus aureus (S. aureus) forms biofilm that causes periprosthetic joint infections and osteomyelitis (OM) which are the intractable health problems in clinics. The silver-containing nanoparticles (AgNPs) are antibacterial nanomaterials with less cytotoxicity than the classic Ag compounds. Likewise, gold nanoparticles (AuNPs) have also been demonstrated as excellent nanomaterials for medical applications. Previous studies have showed that both AgNPs and AuNPs have anti-microbial or anti-inflammatory properties. We have developed a novel green chemistry that could generate the AuAg nanocomposites, through the reduction of tannic acid (TNA). The bioactivity of the nanocomposites was investigated in S. aureus biofilm-exposed human osteoblast cells (hFOB1.19). The current synthesis method is a simple, low-cost, eco-friendly, and green chemistry approach. Our results showed that the AuAg nanocomposites were biocompatible with low cell toxicity, and did not induce cell apoptosis nor necrosis in hFOB1.19 cells. Moreover, AuAg nanocomposites could effectively inhibited the accumulation of reactive oxygen species (ROS) in mitochondria and in rest of cellular compartments after exposing to bacterial biofilm (by reducing 0.78, 0.77-fold in the cell and mitochondria, respectively). AuAg nanocomposites also suppressed ROS-triggered inflammatory protein expression via MAPKs and Akt pathways. The current data suggest that AuAg nanocomposites have the potential to be a good therapeutic agent in treating inflammation in bacteria-infected bone diseases.
Evaluation of Air Pollution Standard Index for NO2Parameter in Jakarta and Bogor
Authors: Yuwono A S , Pinem A V A , Supandi  , Nisa K , Arif C 
Published: January 2023

AbstractOne Indonesian Air Pollution Standard Index (ISPU) parameter is nitrogen dioxide (NO2), with a minimum concentration of 80 μg/Nm3in ISPU 0-50. This research aim was to evaluate NO2concentrations less than 80 μg/Nm3in ambient air and determine the ISPU number based on NO2concentration. This investigation was conducted from February until April 2021, utilising secondary information compilation and field estimations. The method of the NO2concentration test was based on the national standard SNI 7119-2:2017. The run of NO2concentrations obtained from checking the information in Jakarta and Bogor was 6-51 μg/Nm3, and from inspecting came about 17-40 μg/Nm3. NO2concentrations from monitoring data and sampling were deficiently compared to the NO2minimum concentration limit in ISPU. ISPU number for maximum NO2concentration in Jakarta and Bogor was 32, relatively low than the ISPU NO2minimum standard of 0-50. The relevant NO2concentration limits as an initial indicator of ISPU 0-50 were 0-37 μg/Nm3, and for ISPU 51-100 were 38-68 μg/Nm3based on the NO2toxicity study. Based on the research findings, it can be concluded that the relevant concentration of NO2for ISPU 0-50 is 0-37 μg/Nm3, whereas for ISPU 51-100 is 38-68 μg/Nm3.
Mineralogical Study of Bauxite of Kenco Area, Landak District, West Kalimantan Province, Indonesia
Authors: Jafar N , Nurhawaisyah S R , Widodo S , Chalik C A , Wakila M H 
Published: January 2023

Abstract
Indonesia is a country with a tropical climate that allows for high levels of weathering. Bauxite is the result of weathering rocks that have high aluminum content, low iron content, and little quartz content. The formation of bauxite deposits is controlled by source rock which is rich in Al element, tropical climatic conditions, and geomorphological conditions that allow the formation of the accumulation of weathered source rock products. The altered silicate minerals due to weathering result in the silica element being released from the crystal bonds and some iron are released so that the aluminum element is concentrated as a residual precipitate. X-ray diffraction (XRD) analysis on 16 bauxite samples which are estimated to represent the overburden horizon, bauxite ore horizon, clay horizon, and source rock to establish the mineral composition of bauxite. Mineral groups in the overburden horizon, bauxite ore horizon, and clay horizon are alumina, iron, titanium, silicates, carbonates, sulfides, and sulfates, while mineral groups in source rock are iron, titanium, silicate, sulfide, and sulfate. The type of bauxite in the study area is gibbsite bauxite based on the dominant appearance frequency of gibbsite compared to mineral corundum as an alumina group.
The geoelectric approach to analyzing the profile of post-mining nickel laterite deposits in the Motui District, North Konawe Regency, Indonesia
Authors: Mustafa H , Maulana A , Irfan U R , Tonggiroh A 
Published: January 2023

Abstract
The profile of laterite nickel deposits following mining operations can be determined using a geoelectric method, which is crucial information for exploration as well as sustainability. The purpose of this research is to ascertain the physical properties and thickness profile of laterite nickel deposits in the subsurface following mining. The geoelectric method used is resistivity to map variations in the apparent resistivity values of rocks. This value reflects the different types of rock layers in the subsurface. Through the use of two electrodes, an electric current was introduced into the earth, and the potential difference that resulted from this injection was then measured. Based on the configuration of the electrodes utilized, the apparent resistivity value can be determined. The profile of laterite nickel deposits in the Motui post-mining area includes three layers, red limonite, yellow limonite, and bedrock, with resistivity values ranging from 17.0 to 1572 Ωm. The resistivity of the red limonite layer ranges from 17.0 to 1572 Ωm, and its depth is 0 to 10 meters. The yellow limonite layer is between 10 and 20 meters thick and has a resistivity range of 17.0 to 31.8 m. The resistivity of bedrock, on the other hand, ranges from 84.2 to 1572 Ωm at depths between 20 and 70 meters.
Laterite profile study of highly weathered ultramafic rocks from the southern part of Southeast Sulawesi
Authors: Asfar S , Maulana A , Irfan U R , Sufriadin  
Published: January 2023

Abstract
This study was carried out in South Konawe Regency, namely in the southern portion of the Southeastern Arm of Sulawesi, with sampling sites made in four different Block areas: (1) Lati Block (Lalembuu-Tinanggea), (2) Torobulu Block, (3) Bangun Jaya Block, and (4) Laonti Block. Determining the profile of laterite deposits created by weathering processes in ultramafic rocks is the goal of this research. The research approach employed is to identify the physical characteristics of their outcrop layering order from top to bottoms of the laterite deposits, such as their color, texture, layer thickness, and mineral composition. In contrast to laterite deposits generally, laterite deposits developed in the South Southeastern Arm of Sulawesi exhibit a unique profile. In particular, the Southeast Sulawesi Arm region’s tectonic activity is closely related to the potency for the development of laterite deposit profiles. The laterite profile types in the research area can be identified by the overburden of each profile, which consists of limestone, sandstone, and a thin layer of coal.