bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Non-pharmacologic Traditional Chinese Medicine on Health-Related Quality of Life and Symptom Management in Breast Cancer Patients: A Systematic Review and Meta-Analysis
Authors: Fei Wang , Zaremohzzabieh Zeinab , Abdullah Haslinda 
Published: January 2025

Background:
Breast cancer remains a prevalent malignancy among women globally.
Survivors often experience diminished quality of life, pain, and sleep disturbances after treatment
and suffer feelings of isolation. Non-pharmacological traditional Chinese medicine (NP-TCM) interventions
have been increasingly applied in clinical practice, yet their efficacy requires further
clarification.

Objective:
This meta-analysis aimed to evaluate the impact of NP-TCM interventions (e.g. Qigong,
Tai Chi, Baduanjin) on the health-related quality of life (HRQOL) in breast cancer patients.

Methods:
Randomized controlled trials published between 1999 and 2024 were retrieved from various
databases. Studies comparing NP-TCM and control groups in quality of life and other outcomes
were included. Meta-analysis was performed using RevMan 5.4 software. 14 RCTs with 688
patients were included.

Results:
NP-TCM interventions significantly improved overall quality of life (SMD=0.13, 95%CI
0.24~0.51, P<0.001). Specifically, Baduanjin demonstrated substantial benefits (SMD=0.82,
P<0.001). NP-TCM also enhanced sleep (SMD=1.16, P=0.04) and alleviated anxiety (SMD=-0.46,
P<0.05).

Conclusion:
NP-TCM interventions effectively improved the HRQOL and certain symptoms for
breast cancer patients, providing practical adjunctive therapies. However, study qualities require optimization.
Preparation, Evaluation, In vitro Anti-diabetic and Stability Studies of Glibenclamide Loaded Cocrystals
Authors: Malik Jyoti , Khatkar Anurag , Nanda Arun 
Published: January 2025

Background:
Glibenclamide (BCS Class–II .Drug) has poor solubility and high permeability.
In the co-crystallization technique, drugs are combined with a suitable coformer via Hbonding.
Glibenclamide cocrystals have been prepared with various coformers but glibenclamide
cocrystals with vanillic acid have not been prepared yet.

Objective:
To prepare glibenclamide cocrystals with vanillic acid coformer and evaluate them using
various techniques, along with in vivo antidiabetic studies and stability studies.

Method:
Cocrystals containing glibenclamide were produced with vanillic acid coformer by the
solvent evaporation method in a 1:1 molar ratio.

Result:
In FTIR analysis, an H-bond is formed between the amide group of the drug and the carboxylic
acid group of the coformer. With the help of DSC and HSM, the melting point of cocrystals
was observed at a different point compared to the melting point of glibenclamide drug and
vanillic acid coformer. In the XRD analysis of cocrystals, peaks with high intensity were observed
at different points than that of the drug and coformer, confirming the crystalline nature of the formulation.
During in vitro dissolution studies, cocrystals showed a better dissolution profile compared
to the marketed formulation and the pure drug in both acidic and alkaline media. In vivo anti-
diabetic studies were conducted using male Wistar rats, confirming that the glucose reduction
percentage from cocrystals was more than that of the pure drug. During stability studies, no significant
changes occurred in the dissolution profile of the formulation, which indicated that the formulation
was stable after storage at an ambient temperature.

Conclusion:
The results obtained from various characterization techniques indicate that glibenclamide
cocrystals formed from vanillic acid enhance the solubility of glibenclamide.
KW2478 and Cisplatin Synergistically Anti-colorectal Cancer by Targeting PI3K/AKT/mTOR Pathway
Authors: Wang Jianping , An Jun , Tian Lixuan , Jin Yuzi , Li Yalei , Ding Peijian , Yun Wenjing , Zhang Yunpeng , Zhao Shuang 
Published: January 2025

Objective:
The objective of this study is to examine the impact of KW-2478 combined with DDP on colorectal
cancer cells both in vitro and in vivo and to elucidate the molecular mechanism of KW-2478 in colorectal cancer.

Methods:
qRT-PCR and Western blot were employed to assess HSP90 mRNA and protein expression in normal
intestinal epithelial and colorectal cancer cells. DLD-1 and HCT116 were selected for the experiment. CCK-8
was used to detect cytotoxicity; apoptosis rate was measured using flow cytometry; Western blot was employed
to measure the expression levels of apoptotic and PI3K/AKT/mTOR pathway proteins. HCT116 was used to
construct a subcutaneous tumor model in nude mice. After treatment with KW-2478 and DDP, the growth rate,
volume, and weight of the tumor were observed. The expression of Ki67 was detected by immunohistochemistry.
Apoptosis of tumor cells was detected using TUNEL. Western blot was employed to measure the expression
levels of apoptotic and PI3K/AKT/mTOR pathway proteins.

Results:
HSP90 mRNA and protein levels were elevated in colorectal cancer cells compared to normal colorectal
epithelial cells. HSP90 mRNA and protein expression levels were also significantly elevated in HCT116 and
DLD-1 cells compared to other colorectal cancer cells. In DLD-1 and HCT116 cells, KW2478 and DDP inhibited
cell viability. The combination of KW2478 and DDP exhibited a significantly higher inhibitory effect compared
to either KW2478 or DDP alone. DDP markedly triggered apoptosis in HCT116 and DLD-1. KW2478 at 3 μg/ml
and 6 μg/ml induced apoptosis in HCT116 cells but not in DLD-1 cells. The combination of KW2478 and DDP
induced a significantly higher apoptosis rate as compared to either KW2478 or DDP alone. Treatment of HCT116
and DLD-1 with KW2478 or DDP alone increased Bax, Caspase9, and Caspase3 protein expression, while decreasing
BCL-2. The KW2478+DDP combined treatment group exhibited more significant changes. Phosphorylation
of PI3k, AKT, and mTOR decreased in the KW2478 or DDP treatment groups, with more significant
changes observed in the KW2478 + DDP combination group. The growth rate, volume, and weight of subcutaneous
tumors in the KW2478 or DDP treatment groups were significantly lower than control, and the
KW2478+DDP combination group was more affected. Ki67 expression in subcutaneous tumors was reduced in
the KW2478 or DDP treatment groups compared to the vehicle control group, with the lowest expression observed
in the KW2478 + DDP combination group. The fluorescence intensity of subcutaneous tumors was higher
in both the KW2478 and DDP treatment groups compared to the vehicle control group, and the KW2478 + DDP
combination group exhibited the strongest fluorescence intensity among them.

Conclusion:
The combination of KW2478 and cisplatin inhibits colorectal cancer cell proliferation and induces
apoptosis by regulating the PI3K/AKT/mTOR pathway.
Global Publication Trends and Research Hotspots of Diabetes and Osteoporosis
Authors: Zhang Yuan , Ren Qi , Zhao Panmei , Zou Qinghua 
Published: January 2025

Background:
Diabetes and osteoporosis, as chronic diseases with high incidence, have
caused deep concern in the field of global public health due to their high morbidity and mortality.
More importantly, the complex and close relationship between diabetes and osteoporosis has gradually
become the focus of scientific research. It is very meaningful to carry out bibliometric analysis
in the research field of diabetes and osteoporosis to describe the current international trend and
present a visual representation of the past and emerging trends of diabetes and osteoporosis in the
past decade.

Methods:
In this study, the characteristics of the articles on “diabetes and osteoporosis” retrieved
and downloaded from the Web of Science Core Collection [WoSCC] database from January 1,
2011 to December 1, 2022 were analyzed by bibliometrics to clarify the evolution and theme
trends between the two diseases. Citespace software was used for data analysis and visualization,
including countries, academic institutions, journals, authors, subject categories, keywords, references,
and citations. In addition, some important subtopics identified by bibliometric characterization
were further discussed and reviewed.

Results:
Finally, 3372 articles were included in the analysis, including a total of 96 countries, 407
organizations, 1161 journals, and 617 keywords. Articles related to diabetes and osteoporosis
were first published in 2011 and then showed an increasing trend year by year. The United States,
China, Italy, England, and Japan were the top 5 countries associated with the largest number of
publications. University of California-San Francisco, China Medical University, University of
Toronto, Shanghai Jiao Tong University, and Mayo Clinic were the top 5 academic institutions in
terms of the number of published papers. The top 5 authors with the highest number of publications
were William D, Ann V, Nicola, Peter, and Toshitsugu. Osteoporosis International has published
130 articles in this field, ranking first among highly productive journals. In addition to diabetes
and osteoporosis, the most frequently used keywords were bone mineral density, obesity,
and fracture.

Conclusions:
More and more studies have been conducted on diabetes and osteoporosis, and the
current research mainly focuses on the pathogenesis of various chronic diseases. In the future,
more attention may be paid to the prevention and management of these two chronic diseases and
the production and application of new drugs.
Protective Effect of Vitamin D Supplementation Against Atherosclerotic Cardiovascular Disease in Type 1 Diabetes Mellitus Model
Authors: Alhazmi Ayman Saeed 
Published: January 2025

Introduction:
Cardiovascular disease (CVD) is a leading cause of mortality on a global
scale, with a higher prevalence observed among men. This study investigated the protective effect
of vitamin D supplementation on CVD.

Methods:
A cohort of thirty mice was divided into three groups: control, T1 diabetic, and T1 diabetic
groups that received vitamin D treatment. For each mouse in the three groups, measurements
were taken of body weight, blood glucose levels, glycated hemoglobin (HbA1c), lipid profile, cardiac
enzymes, troponin I, adropin, nitric oxide (NO), endothelin-1, and Vascular endothelial
growth factor (VEGF). In addition, measurements were taken for the overall lymphocyte count, as
well as the CD3+, CD4+, CD8+, CD4+, CD25+, and CD8+ CD25+ cell counts in all mice.

Results:
The diabetic mice that received vitamin D treatment exhibited significant reductions in
blood glucose levels, HbA1c levels, lipid profile, cardiac enzymes, troponin I, endothelin-1, and
VEGF levels as compared to the untreated diabetic group (p < 0.01). Furthermore, there was an observed
rise in adropin and NO levels in diabetic mice that received vitamin D treatment compared
to the untreated diabetic group (p < 0.05). The diabetic mice treated with vitamin D exhibited a
substantial decrease in total lymphocyte counts compared to the untreated diabetic and control animals
(p < 0.0001). Regarding the CD3+ subset, it was shown that diabetic mice subjected to vitamin
D treatment had notably elevated levels of these cells compared to both the untreated diabetic
and control groups (p < 0.0001). In addition, the administration of vitamin D resulted in a substantial
decrease in the numbers of CD4+ and CD8+ cells in the group of individuals with diabetes (p <
0.0001). The diabetes group that received vitamin D treatment had significantly reduced populations
of CD4+ CD25+ and CD8+ CD25+ compared to the untreated diabetic group (p < 0.0001).

Conclusion:
Vitamin D maintains the integrity of the cardiovascular system through the reduction
of blood glucose levels and lipid profile. Moreover, its supplementation prevents atherosclerotic
CVD by suppressing inflammatory reactions.
Recent Advances in the Chemistry of Thienopyranone Heterocycles: Synthesis, Reactivity, and Application
Authors: Thabet Hamdy K. , Althagbi Hanan I. , Al Zahrani Nourah A. , Helal Mohamed H. , Gouda Moustafa A. 
Published: January 2025

Abstract:
Thiophene and pyranone are valuable heterocyclic compounds that play a crucial role in
the development of new drug molecules. The combination of thiophene and pyranone moieties in
hybrid structures has opened exciting possibilities for various applications, leading to the discovery
of thienopyranones (Thpyns), such as 5H-thieno[3,2-b]pyran-5-one, 2H-thieno[2,3-b]pyran-2-one,
4H-thieno[3,2-c]pyran-4-one, 7H-thieno[2,3-c]pyran-7-one, all of which exhibit intriguing properties.
This review offers an in-depth analysis of the preparation methods and chemical reactivity of
thienopyranones
Digital Screen Time and Associated Health Factors: A Bibliometric
Study on Global Research Trends Between 2012-2023
Authors: Singh Arti , Lekha P Padma Sri , Jadhav Bhoomika N , Azeez E.P. Abdul 
Published: January 2025

Background:
Screen time has become an inevitable aspect of daily life
due to increased technological access and changes in the social and economic
landscapes. The increase in screen time is associated with the development of
various health conditions. Contextually, research on screen time and its health
impact has been studied widely. Therefore, the present study tried to understand
the trends and themes in the global research on screen time and its associated
health aspects.

Method:
We adopted a bibliometric review, and the data were extracted from the
SCOPUS database, limiting it to 2012-2023 (n =4077). The final number of
studies considered for the analysis was 2919 after applying the inclusion and
exclusion criteria.

Results:
Scientific production has increased over the years on this topic, with few
consistent contributors (Tremblay MS, Chaput JP, and Carson V) and sources
from Western countries leading the production in this domain. In addition, from
the results of thematic network mapping, we identified the basic yet
underdeveloped topics in screen time and health research, namely obesity, risk
factors to health, and mental health. A good proportion of the studies involve
children and adolescents as participants, indicating the growing trend of studying
screen time risk factors for these age groups' health.

Conclusion:
It was evident from the result that the earlier works have focused on
screen time as a risk to health and well-being. However, its role in specific health
conditions is underdeveloped. Further, the case of adolescents and children being
a widely studied age group suggests the implications for their health and mental
health.
Short-term Load Forecasting Based on K-medoids Clustering and XGBTide Model
Authors: Sun Bohao , Pei Yuting , Yan Bo , Wang Zesen , Zhang Liying 
Published: January 2025

Introduction:
Electric power load is significantly influenced by weather conditions,
making accurate load prediction under varying weather scenarios essential for effective planning
and stable operation of the power system. This paper introduces a short-term load forecasting
method that combines k-Medoids clustering and XGB-TiDE. Initially, k-Medoids clusters the
original load data into categories such as sunny, high temperature, and rain/snow days. Subsequently,
XGBoost identifies critical features within these subsequences. The combined forecast
model, XGB-TiDE, is then tailored for each subsequence. Here, the TiDE model's predictions are
refined point-by-point using the XGBoost results to derive the final short-term load forecasts. An
empirical analysis using real power load data from a specific region demonstrates that our proposed
model achieves superior accuracy, especially under extreme weather conditions such as
high temperatures and precipitation.

Background:
Electric power load is significantly influenced by weather conditions, making accurate
load prediction under varying weather scenarios essential for effective planning and stable
operation of the power system.

Objective:
Addressing the limitations of short-term load forecasting under extreme weather conditions,
this paper introduces a novel approach that leverages k-Medoids clustering and the XGBTiDE
model to enhance forecasting accuracy. This method strategically segments power load data
into meaningful clusters before applying the robust predictive capabilities of XGB-TiDE, aiming
for a significant improvement in forecast precision.

Method:
Initially, k-Medoids clusters the original load data into categories such as sunny, high
temperature, and rain/snow days. Subsequently, XGBoost identifies critical features within these
subsequences. The combined forecast model, XGB-TiDE, is then tailored for each subsequence.
Here, the TiDE model's predictions are refined point-by-point using the XGBoost results to derive
the final short-term load forecasts.

Results:
The model presented in this study demonstrates outstanding performance across all
weather conditions, consistently achieving lower mean absolute error (MAE), root mean square error
(RMSE), and mean absolute percentage error (MAPE) compared to other models. For instance, on a
sunny day, this model records an MAE of 8.49, RMSE of 10.29, and MAPE of 2.55%, markedly
surpassing the Autoformer, which shows an MAE of 18.29, RMSE of 22.33, and MAPE of 5.50%.
These results underscore the superior accuracy of our proposed forecasting approach.

Conclusion:
An empirical analysis using real power load data from a specific region demonstrates
that our proposed model achieves superior accuracy, especially under extreme weather conditions
such as high temperatures and precipitation.
Weight Loss Patterns and Outcomes Over 12 Months on a Commercial Weight Management Program (CSIRO Total Wellbeing Diet Online): Large-Community Cohort Evaluation Study
Authors: Hendrie Gilly A , Baird Danielle L , James-Martin Genevieve , Brindal Emily , Brooker Paige G 
Published: January 2025

Background
A greater understanding of the effectiveness of digital self-management programs and their ability to support longer-term weight loss is needed.

Objective
This study aimed to explore the total weight loss and patterns of weight loss of CSIRO (Commonwealth Scientific and Industrial Research Organisation) Total Wellbeing Diet Online members during their first 12 months of membership and examine the patterns of platform use associated with greater weight loss.

Methods
Participants were Australian adults who joined the program between October 2014 and June 2022 and were classified as longer-term members, meaning they completed at least 12 weeks of the program, had baseline and 12-week weight data, and had a paid membership of ≥1 year (N=24,035). Weight loss and percentage of starting body weight loss were calculated at 3, 6, 9, and 12 months using 3 statistical approaches: (1) multiple imputations method, (2) all available data, and (3) complete data only. Among members with complete data (6602/24,035, 27.5%), patterns of weight loss and gain were examined, and how this related to total weight loss and platform use was explored.

Results
Members were mostly female (19,972/24,035, 83.09%), aged 31 to 50 years (9986/24,035, 41.5%) or 51 to 70 years (12,033/24,035, 50.06%), and most members were classified as overweight or obese (23,050/24,035, 95.9%). Using multiple imputations, the average estimated weight loss was 5.9 (SE 0.0245) kg at 12 weeks, 6.7 (SE 0.0348) kg at 6 months, 6.2 (SE 0.0400) kg at 9 months, and 5.5 (SE 0.0421) kg at 12 months. At 12 months, more than half the members (12,573/24,035, 52.3%) were at least 5% below their starting body weight and 1 in 4 (5865/24,035, 24.4%) were at least 10% below their starting body weight. In the subsample with complete data, the average weight loss at 12 months was 7.8 kg. The most common (961/6602, 14.56% members) weight loss pattern over the first 12 months was 6 months of weight loss, followed by 6 months of weight maintenance. This group had an average weight loss of 10.6 kg at 12 months (11.9% of their starting body weight). In a subgroup of participants who consistently lost weight over the 12-month period (284/6602, 4.3% of the sample), weight loss reached up to 22.3 kg (21.7% of their starting body weight). Weekly platform use was positively associated with total weight loss (r=0.287; P<.001). Members who used the platform >30 times per week (approximately >4 times/d) were more likely to lose weight in the first 6 months of the program.

Conclusions
This commercial weight loss program was shown to be effective, with 1 in 2 members achieving clinically significant results after 1 year. Greater engagement with the platform was associated with consecutive periods of weight loss and greater weight loss success overall.
Study persistence as a characteristic problem of current elementary art education in the Czech republic: A case study
Authors:   University of Ostrava, Zubíček Jaromír 
Published: January 2025

The education system for teaching singing or playing musical instruments has a long tradition in the Czech Republic. State-guaranteed studies organized in elementary art schools provide students with the basics of education that these starting artists can later develop further at conservatories and universities. Thanks to equal treatment and an extensive network of schools, more than 10% of the total population of Czech citizens aged between 5 and 18 attend the music field. The study aims to find out how many students properly complete their music studies with a leaving certificate and which school years are critical for the successful completion of studies in musical performance or singing. The research was conducted in the Czech Republic at the Elementary Art School in Ostrava, Sokolská třída 15, through a case study of qualitative research and document analysis. The documents included statistical data of 938 pupils studying at the surveyed school during 2007–2024. The research results found by analyzing the documents are divided by individual musical instruments and grades of study.
MISTERUL ȘI SENSUL MORȚII ÎN CREȘTINISM
Authors: CHIVARI Alex - Dominic 
Published: January 2025

The Mistery and Meaning of Death in Christianity. What is our hope as Christians? What are we looking forward to? What future does God have in store for us after we die? Will it involve this beautiful earth as well as all of creation? To raise these kinds of questions is to ask ourselves questions about eschatology, about realities and the end times. Given that, as we said above, the Christian faith is essentially eschatological, we eagerly await the coming of the Eschaton, having the hope of the coming of the age of salvation, of the establishment of the Kingdom of Heaven. Eschatology should occupy a central place in our Christian faith, because without a belief in the realities of the future, we have no hope.