bluuebunny/crossref_metadata_2025_split huggingface dataset:
2025年开元教育科技（深圳）有限公司教育部产学合作协同育人项目申报指南
Authors: 开元教育科技（深圳）有限公司  
Published: January 2025

在教育部指导下，开元教育科技（深圳）有限公司开展产学合作协同育人项目，包含新工科、新医科、新农科、新文科建设项目5项，教学内容和课程体系改革项目5项，师资培训项目6项，实践条件和实践基地建设项目9项，共四大类25项。产学合作协同育人项目旨在发挥企业优势，助力推进高质量高等教育体系建设，提高高等教育质量，培养理工农医类专业紧缺人才，服务制造强国、质量强国、网络强国、数字中国建设，为培养产业急需的高素质创新人才提供有力支撑，以产业和技术发展的最新需求推动高校人才培养改革。Under the guidance of the Ministry of Education, Creative Education Technology (Shenzhen) Co., Ltd. is launching the University-Industry Collaborative Education Program, which includes 25 projects across four major categories: Five projects for the development of emerging disciplines (New Engineering, New Medicine, New Agriculture, and New Liberal Arts); Five projects for the reform of teaching content and curriculum systems; Six faculty training projects; Nine projects for building practical conditions and practice bases. The University-Industry Collaborative Education Program aims to leverage corporate strengths to promote the construction of a high-quality higher education system, improve the quality of higher education, and cultivate urgently needed talent in science, engineering, agriculture, and medicine. It seeks to support the development of a strong manufacturing, quality, and digital nation while meeting the latest industry and technological demands. This initiative will drive the reform of talent cultivation in universities and provide robust support for nurturing high-quality, innovative talent to meet the needs of modern industries.
2025年中医药传承创新发展创新创业联合基金项目申报指南
Authors: 开元教育科技（深圳）有限公司  
Published: January 2025

2025年，开元教育科技（深圳）有限公司设立教育部产学合作协同育人项目中医药传承创新发展创新创业联合基金项目25项，旨在贯彻党的二十大报告“促进中医药传承创新发展”精神，贯彻落实《中共中央国务院关于促进中医药传承创新发展的意见》、国务院《中医药发展战略规划纲要（2016—2030年）》《“十四五”中医药发展规划》等文件精神，落实国家中医药发展战略，构建完善的中医药人才培养体系，推动中医药的传承与创新发展，提升中医药国际健康合作水平，弘扬中医药文化，以产业和技术发展的最新需求推动高校人才培养改革，促进中医药可持续发展。欢迎全国本科高校本科生、硕士生和博士生申报。
In 2025, Kaiyuan Education Technology (Shenzhen) Co., Ltd. will establish 25 projects under the Ministry of Education's Industry-Academia Collaboration Cooperative Education Program, focusing on the Innovation and Entrepreneurship Joint Fund for the Preservation and Innovative Development of Traditional Chinese Medicine (TCM). The initiative aims to implement the spirit of the 20th National Congress of the Communist Party of China, which emphasizes “promoting the preservation and innovative development of TCM.” It also seeks to fulfill the requirements of key national policy documents, including the Opinions of the Central Committee of the Communist Party of China and the State Council on Promoting the Preservation and Innovative Development of TCM, the Outline of the Strategic Plan for TCM Development (2016–2030), and the 14th Five-Year Plan for TCM Development. The program is aligned with the national TCM development strategy, focusing on building a comprehensive TCM talent cultivation system, advancing the preservation and innovative development of TCM, enhancing international health cooperation in TCM, and promoting TCM culture. By addressing the latest demands in industry and technology, it also aims to reform university talent cultivation and foster the sustainable development of TCM. Undergraduate, master’s, and doctoral students from universities across the country are encouraged to apply.
PROJETO MAQUETES PARA SURDOS: UM RELATO DE EXPERIÊNCIA
Authors: Cruz Miriam da 
Published: January 2025

ABSTRACT

This article discusses the interactive model project developed with deaf students from the Technical High School at Helen Keller School in São Paulo, highlighting the use of digital technologies such as QR codes to promote accessibility and inclusion. The experience revealed challenges in teaching network infrastructure to the deaf community but presented innovative solutions that could serve as a model for other institutions.

Keywords: Inclusive education; Deafness; Network infrastructure; QR codes; Assistive technology.
Pengaruh Penggunaan Media Pembelajaran Animasi Powtoon terhadap Kecerdasan Visual Spasial Siswa Pada Mata Pelajaran Matematika Kelas VI MI Miftahul Khoer
Authors: Indra Saeful Hidayat  , Agus Abdullah Ashari  
Published: January 2025

This research was conducted at MI Miftahul Khoer, Kumpay village, Jalancagak. This research is a quantitative research with a Quasy Experiment type or research. The population in this study were all students of MI Miftahul Khoer, totalling 200. The sample of this study consisted of 1 class totalling 30 students and divided into 2 groups consisiting of an experimental group with 15 students and a control group with 15 students person. The test instrument used to determine the visual-spatial intelligence of science subjects was a multiple choice test in the form of a post-test which consisted of 10 questions. The data analysis technique used in this study used the t test. Based on the research that has been carried out, it can be concluded that there is an influence of powtoon animation learning media on the visual spatial intelligence of students in mathematics at MI Miftahul Khoer.
Interrogativas indirectas con MH e Indicativo en la medicina griega: un rasgo de empatía.
Authors: García Novo Elsa 
Published: January 2025

Los médicos griegos utilizan ocasionalmente una interrogativa indirecta introducida por μ? y seguida de Indicativo, para indagar sobre un síntoma desfavorable del enfermo: “Pregunto, pues me temo que tiene …” Expresan de este modo su rechazo a la probable gravedad del paciente, dando así muestras de empatía.
Assessment of complications and success rates of Percutaneous nephrolithotomy: single tract vs. multi tract approaches
Authors: Memik Ömür , Karslı Onur 
Published: January 2025

Purpose
The objective of this study was to assess the success and complication rates of single-tract access vs. multi-tract percutaneous nephrolithotomy (PNL).

Material and Methods
The medical records of consecutive patients who underwent PNL for staghorn, partial staghorn, and complex kidney stones between 2014 and 2022 were retrospectively reviewed. The demographic data, stone volumes, fluoroscopy and operation durations, changes in hemoglobin levels, numbers of blood transfusions, stone-free rates, perioperative complications, duration of nephrostomy removal, and length of hospital stay parameters were noted. The complications and complexity of PNL were graded using the modified Clavien and Guy’s stone scores, respectively. Single and multi-tract subgroups were determined based on PNL access strategy and the subgroups were analyzed.

Results
The study involved 208 patients, with 158 in the single-tract group and 50 in the multi-tract group. The groups were comparable in age, ASA scores, and comorbidities (p > 0.05). The characteristics of the stones, such as their location, size, and density, did not show any significant differences between the groups (p > 0.05), except for Guy’s stone score, which was higher in the multi-tract group (p = 0.028). The multi-tract group also had significantly longer fluoroscopy and operation times (p < 0.001). There was no statistically significant difference in stone-free rates between the two groups (76.0% vs. 78.0%, p = 0.766). Although the drop in hemoglobin levels was more significant in the multi-tract group (p = 0.027), transfusion rates did not differ significantly between the two groups (p = 0.334). Complication rates were higher in the multi-tract group, but this difference was not statistically significant (p = 0.896).

Conclusion
This study demonstrated that multi-tract PNL can achieve high stone-free rates with a modest increase in the occurrence of acceptable complications when performed by an experienced surgeon.
Nitrogen fertilizer application for improving the biomass, quality, and nitrogen fixation of alfalfa (Medicago sativa L.) at different growth stages in a saline‒alkali soil
Authors: Wan Weifan , Liu Qian , Li Ke , Zhao Kun , Qi Fei , Li Yuanshuo , Sun Zhi , Li Haigang 
Published: January 2025

Background
The application of nitrogen (N) fertilizer to alfalfa (Medicago sativa L.) has received little attention due to the ability of this plant to fix N. However, N deficiency stress is often observed in marginal lands of China, especially in saline–alkali soils. Thus, this study aimed to assess the response of alfalfa yield, quality, N fixation, and soil N concentration to N fertilizer application at different stages in saline–alkali soil of Inner Mongolia. A 2-year (2020 and 2021) field experiment with five N fertilizer application rates, namely, 0 (N0), 20 (N20), 60 (N60), 120 (N120) and 180 (N180) kg N ha−1, was conducted in Inner Mongolia.

Results
The results showed that N fertilizer application of 180 kg ha−1 significantly increased the total alfalfa yield by 29%–32% by improving the stem‒leaf ratio; however, it didn’t lead to a further increase in alfalfa quality. N fertilizer applications of 60 and 120 kg ha−1 significantly improved the crude protein by 10.6%–22.7% and reduced the acid or neutral detergent fiber by 10.0%–18.7% in vegetative and bud stages, respectively, by improving the leaf N concentration. Furthermore, the fraction of N derived from the atmosphere reached 68.6%, with a significant increase in the corresponding amount of N fixed in N60. Soil NO3−-N concentrations significantly increased by 24.1%–33.3%, and NH4+-N concentrations increased by 1 to 3 times when N fertilizer application exceeded 120 kg N ha−1 compared with that in N0.

Conclusions
Overall, this study revealed the essential role of N fertilizer application at low rates in alfalfa production, as this practice not only increases alfalfa yield but also improves N fixation in saline‒alkali soil. However, it did not result in further improvement in alfalfa quality at the early flowering stage. The findings provides valuable guidance for N fertilizer application in alfalfa production on saline‒alkali soils.
Association between phase angle, body mass index and insulin resistance in patients with type 2 diabetes mellitus: a cross-sectional study
Authors: Hu Yezi , Jin Hui 
Published: January 2025

Background: The purpose of this analysis was to investigate the associations between phase angle (PhA), body mass index (BMI) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM).
Methods: The retrospective cross-sectional study included 200 T2DM patients treated during 2018 to 2019 in Zhongda Hospital Southeast University. PhA and other body composition indicators were measured by bioelectrical impedance analysis (BIA). Subjects were classified into four groups based on body composition: low phase angle and low body mass index (LPLB), low phase angle and high body mass index (LPHB), high phase angle and low body mass index (HPLB) and high phase angle and high body mass index (HPHB).
Results: Overall, in the unadjusted model and minor, all adjusted models (unadjusted model, models 1–4), homeostasis model assessment of insulin resistance (HOMA-IR) was higher in the LPHB group than in the LPLB group (P = 0.034). In the unadjusted model, Model 1 (adjustment for age), Model 2 (adjust for age+duration), Model 3 (adjust for age+duration+sex+UA+TG+TC) and Model 4 (adjust for age+duration+sex+UA+TG+TC+HDL+HbA1c), the adjusted ORs for participants were 4.4 (95% CI [1.72–11.24]), 4.41 (95% CI [1.73–11.27]), 4.75 (95% CI [1.83–12.32]), 2.93 (95% CI [1.04–8.23]) and 3.1 (95% CI [1.09–8.86]) respectively, compared to LPHB group.
Conclusions: T2DM patients with the body composition of low phase angle and high body mass index exhibited the most severe degree and the highest risk of insulin resistance.
Prevalence and Pattern of Neurological Disorders amongst Children Attending the Neurology Clinic of a Private Paediatric Hospital in Southern Nigeria
Authors: West Boma Awoala , Aitafo Josephine Enekole 
Published: January 2025

Aim: Neurologic disorders are a common cause of morbidity and disability in children worldwide. There is a dearth of knowledge of neurologic disorders in private health facilities thus this study was done to determine the prevalence and pattern of these disorders.
Study Design: It was a retrospective study.
Place and Duration of Study: This study was carried out in a private paediatric hospital in Southern Nigeria over 1-year between 1st January, 2023 and 31th December, 2023.
Methodology: Data was extracted from the hospital’s health management system and analysed.
Results: Of the 22,965 outpatient clinic visits during the study period, 203 had neurological disorders giving a prevalence rate of 0.9% with slight female predominance 107(52.7). Most common age group was 1 - < 5 years (43.4%).
Single neurologic disorders predominated 123 (63.4%). Commonest neurological disorders were seizure disorder (54.6%), autism spectrum disorder (24.3%) and attention deficit hyperactive disorder (11.3%) with the commonest risk factors for neurologic disorders being severe perinatal asphyxia (42.1%) and severe neonatal jaundice (42.1%). There were significantly more males than females with seizure disorder (P value .013) whereas cerebral palsy was significantly more in females (P value .002). Seizure disorder and learning disorder were significantly more in children ³ 5years (P value of .001 & .030 respectively) whereas cerebral palsy and speech impairment were significantly more in children < 5years (P value of < .001 & .030 respectively).
Conclusion: The prevalence of neurologic disorders was low, being 0.9% with children under 5 years being mostly affected. Commonest neurologic disorders were seizure disorder, autism spectrum disorder and attention deficit hyperactive disorder while perinatal asphyxia and neonatal jaundice were the commonest risk factors.
Public enlightenment campaigns about neurologic disorders and the availability of care would improve the outcome of affected children.
Linking the Pre-Steady-State, Steady-State, and Zero-Order Kinetic Parameters Together for Industrial Applications
Authors: Iloh Udema Ikechukwu 
Published: January 2025

There appeared not to have been a way of linking pre-zero-order kinetics to zero-order kinetics so as to garner key kinetic parameters at very high industrial concentrations of the substrate. The objectives were the derivation of equations that can be explored in relating pre-zero-order (pre-steady-state (prss)) to zero-order kinetic parameters (ZOK), such as the Michaelis-Menten constant (KM), maximum velocity of catalysis (Vmax), and specificity constant (SC), to be evaluated. The Vmax for the higher industrial-type concentration of the enzyme (alpha-amylase) was 7812.5 micromoles/l/min, while the KM was 115.1 g/l. The SC obtained by calculation, either by the new equation (Eq. (25b)) or the ratio Vmax:KM, was 67.88 micromoles l/g min. Surprisingly, as compared to the literature, the SC obtained by the new graphical method was 275.4 micromoles l/g min using sub-KM values of substrate concentrations. The prss Vmax and KM were 2348.62 ± 479.94 micromoles l/g min and 7.41 ± 1.77 g/l, respectively. There is a justification for an equation linking PRSS and the ZOK, which can enhance reactor design. The equation linking PRSS to the ZOK kinetic parameters was derived. With the equation, the KM for a very high industrial concentration of the substrate and the enzyme that would have been impossible was made possible. Future studies may focus on assays at high concentrations of the enzyme and sub-KM concentrations of the substrate so as to observe a repeat of higher SC. Note that if the concentration of one enzyme is twice (or more) the concentration of another enzyme of the same kind, the Vmax of the first should be twice the Vmax of the latter given saturating concentrations of the substrate for each enzyme; the parameter that is constant is the catalytic first-order rate constant (kcat); it may be theoretically assumed that the KM can follow the same order as with the Vmax. Apart from a very high concentration of the gelatinized starch that retards the mobility of the enzyme, the spectrophotometer has an upper limit of its power to read color development.
Empirical Relationship between Compressive, Flexural and Splitting Tensile Strengths of Concrete Containing Kuta Gravel as Coarse Aggregate
Authors: Abubakar Jibrin , Abdullahi Mohammed , Aguwa James Isiwu , Abbas Bala Alhaji , Kolo Daniel Ndakuta 
Published: January 2025

Flexural and tensile strengths of concrete are of great importance in structural engineering. Understanding the flexural strength of concrete helps designers prevent and control development of cracks in concrete elements, ensuring durability. In addition to serviceability, shear, bond failure and flexural capacity in concrete members are directly linked to the tensile strength of the concrete. When compared to flexural and tensile strengths, determination of the compressive strength of concrete is easier to carry out in the field. It is therefore, customary to determine the compressive strength and correlate it to other strength properties. In this study, empirical relationships have been developed to relate the compressive strength to the flexural and splitting tensile strengths of concrete using Kuta river gravel as coarse aggregate. Using varying total aggregate to cement, coarse aggregate to total aggregate and water to cement ratios, 20 mixes were generated using Central Composite Design (CCD) in Minitab 21. The compressive, flexural and splitting tensile strengths of concrete samples from these mixes were determined at 28 days of age. From the strength data obtained, regression equations were developed that relate the strength properties with the aid of regression analysis tool in Microsoft Excel. The empirical models developed to predict the flexural and splitting tensile strengths of concrete from the compressive strength recorded R2 values of 1 for both models, P-values of and , and standard errors of 0.21 and 0.06 respectively. Furthermore, residuals from the values of predicted strength properties show that there is very slight deviation between the experimental and predicted values. It was concluded that the empirical equations developed are significant, have high predictive capabilities and can be used in predicting the flexural and splitting tensile strengths of concrete.
Association Between Markers of Structural Racism and Mass Shooting Events in Major US Cities
Authors: Ghio Michael , Simpson John Tyler , Ali Ayman , Fleckman Julia M. , Theall Katherine P. , Constans Joseph I. , Tatum Danielle , McGrew Patrick R. , Duchesne Juan , Taghavi Sharven 
Published: July 2023

ImportanceThe root cause of mass shooting events (MSEs) and the populations most affected by them are poorly understood.ObjectiveTo examine the association between structural racism and mass shootings in major metropolitan cities in the United States.Design, Setting, and ParticipantsThis cross-sectional study of MSEs in the 51 largest metropolitan statistical areas (MSAs) in the United States analyzes population-based data from 2015 to 2019 and the Gun Violence Archive. The data analysis was performed from February 2021 to January 2022.ExposureShooting event where 4 or more people not including the shooter were injured or killed.Main Outcome and MeasuresMSE incidence and markers of structural racism from demographic data, Gini income coefficient, Black-White segregation index, and violent crime rate.ResultsThere were 865 MSEs across all 51 MSAs from 2015 to 2019 with a total of 3968 injuries and 828 fatalities. Higher segregation index (ρ = 0.46, P = .003) was associated with MSE incidence (adjusted per 100 000 population) using Spearman ρ analysis. Percentage of the MSA population comprising Black individuals (ρ = 0.76, P &amp;lt; .001), children in a single-parent household (ρ = 0.44, P &amp;lt; .001), and violent crime rate (ρ = 0.34, P = .03) were other variables associated with MSEs. On linear regression, structural racism, as measured by percentage of the MSA population comprising Black individuals, was associated with MSEs (β = 0.10; 95% CI, 0.05 to 0.14; P &amp;lt; .001). Segregation index (β = 0.02, 95% CI, −0.03 to 0.06; P = .53), children in a single-parent household (β = −0.04, 95% CI, −0.11 to 0.04; P = .28), and Gini income coefficient (β = −1.02; 95% CI, −11.97 to 9.93; P = .93) were not associated with MSEs on linear regression.Conclusions and RelevanceThis study found that major US cities with higher populations of Black individuals are more likely to be affected by MSEs, suggesting that structural racism may have a role in their incidence. Public health initiatives aiming to prevent MSEs should target factors associated with structural racism to address gun violence.
Enhancing the Thermoelectric Properties via Modulation of Defects in P‐Type MNiSn‐Based (M = Hf, Zr, Ti) Half‐Heusler Materials
Authors: Ai Xin , Lei Binghua , Cichocka Magdalena O. , Giebeler Lars , Villoro Ruben Bueno , Zhang Siyuan , Scheu Christina , Pérez Nicolás , Zhang Qihao , Sotnikov Andrei , Singh David J. , Nielsch Kornelius , He Ran 
Published: July 2023

AbstractThe thermoelectric figure‐of‐merit (zT) of p‐type MNiSn (M = Ti, Zr, or Hf) half‐Heusler compounds is lower than their n‐type counterparts due to the presence of a donor in‐gap state caused by Ni occupying tetrahedral interstitials. While ZrNiSn and TiNiSn, have been extensively studied, HfNiSn remains unexplored. Herein, this study reports an improved thermoelectric property in p‐type HfNi1−xCoxSn. By doping 5 at% Co at the Ni sites, the Seebeck coefficient becomes reaching a peak value exceeding 200 µV K−1 that breaks the record of previous reports. A maximum power factor of ≈2.2 mW m−1 K−2 at 973 K is achieved by optimizing the carrier concentration. The enhanced p‐type transport is ascribed to the reduced content of Ni defects, supported by first principle calculations and diffraction pattern refinement. Concomitantly, Co doping also softens the lattice and scatters phonons, resulting in a minimum lattice thermal conductivity of ≈1.8 W m−1 K−1. This leads to a peak zT of 0.55 at 973 K is realized, surpassing the best performing p‐type MNiSn by 100%. This approach offers a new method to manipulate the intrinsic atomic disorder in half‐Heusler materials, facilitating further optimization of their electronic and thermal properties.
A Cholesterol Metabolic Regulated Hydrogen‐Bonded Organic Framework (HOF)‐Based Biotuner for Antibody Non‐Dependent Immunotherapy Tailored for Glioblastoma
Authors: Yin Na , Wang Yinghui , Liu Yang , Niu Rui , Zhang Shuai , Cao Yue , Lv Zhijia , Song Shuyan , Liu Xiaogang , Zhang Hongjie 
Published: July 2023

AbstractThe metabolic reprogramming of glioblastoma (GBM) poses a tremendous obstacle to effective immunotherapy due to its impact on the immunosuppressive microenvironment. In this work, a hydrogen‐bonded organic framework (HOF) specifically designed for GBM immunotherapy is developed, taking advantage of the relatively isolated cholesterol metabolism microenvironment in the central nervous system (CNS). The HOF‐based biotuner regulates extra/intracellular cholesterol metabolism, effectively blocking the programmed cell death protein 1/programmed death‐ligand 1 (PD‐1/PD‐L1) pathway and reducing 2B4 expression. This metabolically disrupts the immunosuppressive microenvironment of GBM and rejuvenates CD8+ T cells. Moreover, cholesterol metabolism regulation offers additional benefits in treating GBM invasion. Furthermore, tumor microenvironment (TME)‐initiated chemiexcited photodynamic therapy (PDT) is enhanced during the regulation of cholesterol metabolism, and the biotuner can effectively trigger immunogenic cell death (ICD) and increase the infiltration of cytotoxic T lymphocytes (CTLs) in GBM. By reversing the immunosuppressive microenvironment and bolstering chemiexcited‐PDT, this approach invigorates efficient antibody non‐dependent immunotherapy for GBM. This study provides a model for enhancing immunotherapy through cholesterol metabolism regulation and explores the feasibility of a “metabolic checkpoint” strategy in GBM treatment.