bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mental labyrinth of postgraduate research: a qualitative study of postgraduate mental health and wellbeing and the impact of the supervisory relationship
Authors: White Naomi , Milicev Jelena , Bradford Daniel R. R. , Rodger Amy , Gardani Maria 
Published: June 2023

AbstractPostgraduate research students (PGRs) experience disproportionately high levels of psychological distress. Many factors contribute to this poor mental wellbeing and relate to each other in complex and dynamic ways. However, the relationship between PGRs and their supervisor(s) is known to strongly affect the wellbeing of the former. This study explores the mental health and wellbeing of PGRs with a focus on the role of the student—supervisor relationship. Using combined qualitative data from a large survey of PGRs and focus groups and reflexive thematic analysis, we found that PGRs experience the overarching process of obtaining a research degree as a mental labyrinth. Three constituent themes were identified: (1) inequity in navigating the labyrinth, (2) the labyrinth as a place of uncertainty and isolation, and (3) supervisors as labyrinth guides, not mental care providers. The results suggest that significant inequities exist which contribute to poorer mental wellbeing in particular subgroups of PGRs, both in general and specifically in relation to the supervisory relationship. Experiences of loneliness and ambiguity around progress were also identified as being detrimental to mental health. Furthermore, although supervisors can be a vital source of support and have a positive influence on PGR mental health, students recognise supervisors cannot reasonably be expected to act as professional mental health care providers and institutions must do more to provide equitable access to mental health support services.
Scientific collaboration amid geopolitical tensions: a comparison of Sweden and Australia
Authors: Shih Tommy , Chubb Andrew , Cooney-O’Donoghue Diarmuid 
Published: June 2023

Abstract
Significant collaborations with research partners in China are seen in many Western countries. With increasing US-China geopolitical tensions, governments, research institutions, and individuals in established scientific systems are increasingly required to address a proliferating array of risks and challenges associated with collaboration with China. Academic researchers are only beginning to describe how countries are responding to the ongoing need for global scientific collaboration amidst intensifying geopolitical competition. Several studies have examined the securitization of scientific connections with China in the USA, while others have documented developments in nations such as Australia, the UK, and Sweden. However, there is limited comparative research on approaches to international science amid geopolitical tensions. This paper bridges the gap, illuminating the key dimensions of variation in country-level responses by comparing the cases of Sweden and Australia. The questions we ask are as follows: Who responds to the challenges? By what means? And to what ends are responses directed? Swedish government have been largely passive, but Swedish funding agencies have developed “responsible internationalisation” guidelines that aim to induce proactive reflection by institutions and individual researchers. Australia’s approach, by contrast, has centred on legislation, the exercise of ministerial powers, along with sector-wide enactment of expanded due diligence protocols. The comparison highlights key differences in the actors, methods and goals of responses to the intensifying geopolitics of scientific collaboration.
Current and historical patterns of recruitment of Yellowstone cutthroat trout in Yellowstone Lake, Wyoming, as revealed by otolith microchemistry
Authors: Stewart Kole P. , McMahon Thomas E. , Koel Todd M. , Humston Robert 
Published: June 2023

AbstractYellowstone cutthroat trout inhabiting Yellowstone Lake have declined substantially over the past 25 years as a result of predation by invasive lake trout, the presence of whirling disease, and periods of persistent drought. We used otolith microchemistry to assess whether cutthroat trout recruitment patterns have changed in response to these environmental stressors. Though water chemistry variation among the 22 sampled spawning tributaries was low, we identified 9 distinct spawning stream clusters. Random forest models were developed for assessing relative recruitment, yielding a high classification accuracy of 84.4% for known-origin cutthroat trout fry otoliths and 79.0% for simulated otolith signatures based on water chemistry. Proportion of recruitment varied significantly between pre- and post-stressor samples (X2 = 15.40,P = 0.03). The majority of pre- (0.84) and post-stressor (0.77) recruitment occurred in the same three stream clusters, but there was a notable decrease in recruitment in streams with high whirling disease prevalence, and a notable increase from the tributary cluster without whirling disease and with low lake trout predation risk. Conservation efforts should be focused on protecting important spawning tributaries and improving cutthroat trout recruitment in spawning streams that in the past likely contributed much greater numbers of fish.
Mito-TEMPO mitigates 5-fluorouracil-induced intestinal injury via attenuating mitochondrial oxidative stress, inflammation, and apoptosis: an in vivo study
Authors: Tambe Prasad Kisan , Qsee H. S. , Bharati Sanjay 
Published: June 2023

Abstract
Background
Recent evidences highlight role of mitochondria in the development of 5-fluorouracil (5-FU)-induced intestinal toxicity. Mitochondria-targeted antioxidants are well-known for their protective effects in mitochondrial oxidative stress- mediated diseases. In the present study, we investigated protective effect of Mito-TEMPO in 5-FU-induced intestinal toxicity.

Methods
Mito-TEMPO (0.1 mg/kg b.w.) was administered intraperitoneally to male BALB/c mice for 7 days, followed by co-administration of 5-FU for next 4 days (intraperitoneal 12 mg/kg b.w.). Protective effect of Mito-TEMPO on intestinal toxicity was assessed in terms of histopathological alterations, modulation in inflammatory markers, apoptotic cell death, expression of 8-OhDG, mitochondrial functional status and oxidative stress.

Results
5-FU administered animals showed altered intestinal histoarchitecture wherein a shortening and atrophy of the villi was observed. The crypts were disorganized and inflammatory cell infiltration was noted. Mito-TEMPO pre-protected animals demonstrated improved histoarchitecture with normalization of villus height, better organized crypts and reduced inflammatory cell infiltration. The inflammatory markers and myeloperoxidase activity were normalized in mito-TEMPO protected group. A significant reduction in intestinal apoptotic cell death and expression of 8-OhDG was also observed in mito-TEMPO group as compared to 5-FU group. Further, mtROS, mtLPO and mitochondrial antioxidant defense status were improved by mito-TEMPO.

Conclusion
Mito-TEMPO exerted significant protective effect against 5-FU-induced intestinal toxicity. Therefore, it may be used as an adjuvant in 5-FU chemotherapy.
From Blind Spot to Crucial Concept: On the Role of Animal Welfare in Food System Changes towards Circular Agriculture
Authors: Meijboom Franck L.B. , Staman Jan , Pothoven Ru 
Published: June 2023

AbstractAgriculture in Western Europe has become efficient and productive but at a cost. The quality of biodiversity, soil, air, and water has been compromised. In the search for ways to ensure food security and meet the challenges of climate change, new production systems have been proposed. One of these is the transition to circular agriculture: closing the cycles of nutrients and other resources to minimise losses and end the impact on climate change. This development aims to address existing problems in food production but also raises questions about animal health and welfare. Although the role animals can play in this development is not ignored, the animal welfare dimension of circular agriculture seems to be overlooked. We argue that this is a problem both for the success of circular agriculture and for the animals involved. To substantiate this claim, we analyse the background to this lack of attention, which we find in (a) the way circular agriculture is conceptualised; (b) the institutional hurdles related to the legal, political and economic context; and (c) the concept of animal welfare, which requires further innovation. By analysing these aspects, we develop stepping stones for an animal-welfare inclusive concept of circular agriculture. These stepping stones include: recognising the animal as a participant with its own interests in the innovation towards circular agriculture; using a dynamic concept of animal welfare; a concept of circularity that provides space for social values, including animal welfare; and attention to institutional innovation by improving public engagement and building trust.
Propagation of Chaos for Weakly Interacting Mild Solutions to Stochastic Partial Differential Equations
Authors: Criens David 
Published: June 2023

AbstractThis article investigates the propagation of chaos property for weakly interacting mild solutions to semilinear stochastic partial differential equations whose coefficients might not satisfy Lipschitz conditions. Furthermore, we establish existence and uniqueness results for mild solutions to SPDEs with distribution dependent coefficients, so-called McKean–Vlasov SPDEs.
A Versatile Stochastic Dissemination Model
Authors: Chan K. M. D. , Mandjes M. R. H. 
Published: June 2023

AbstractThis paper considers a highly general dissemination model that keeps track of the stochastic evolution of the distribution of wealth over a set of agents. There are two types of events: (i) units of wealth externally arrive, and (ii) units of wealth are redistributed among the agents, while throughout Markov modulation is allowed. We derive a system of coupled differential equations describing the joint transient distribution of the agents’ wealth values, which translate into linear differential equations when considering the corresponding means and (co-)variances. While our model uses the (economic) terminology of wealth being distributed over agents, we illustrate through a series of examples that it can be used considerably more broadly. Indeed, it also facilitates the analysis of the spread of opinions over a population (thus generalizing existing opinion dynamics models), and the analysis of the dynamics of a file storage system (thus allowing the assessment of the efficacy of storage policies).
Targeted Activation of HNF4α by AMPK Inhibits Apoptosis and Ameliorates Neurological Injury Caused by Cardiac Arrest in Rats
Authors: Zhan Haohong , Zhang Qiang , Zhang Chenyu , Cheng Jingge , Yang Yilin , Liu Cong , Li Shuhao , Wang Chuyue , Yang Junqin , Ge Hanmei , Zhou Dawang , Li Bo , Wei Hongyan , Hu Chunlin 
Published: June 2023

AbstractPrevious studies have shown that AMPK plays an important role in cerebral ischemia–reperfusion injury by participating in apoptosis, but the exact mechanism and target of action remains unclear. This study aimed to investigate the protective mechanism of AMPK activation on brain injury secondary to cardiac arrest. HE, Nills and TUNEL assays were used to evaluate neuronal damage and apoptosis. The relationships between AMPK, HNF4α and apoptotic genes were verified by ChIP-seq, dual-luciferase and WB assays. The results showed that AMPK improved the 7-day memory function of rats, and reduced neuronal cell injury and apoptosis in the hippocampal CA1 region after ROSC, while the use of HNF4α inhibitor weakened the protective effect of AMPK. Further research found that AMPK positively regulated the expression of HNF4α, and AMPK could promote the expression of Bcl-2 and inhibit the expression of Bax and Cleaved-Caspase 3. In vitro experiments showed that AMPK ameliorated neuronal injury by inhibiting apoptosis through the activation of HNF4α. Combined with ChIP-seq, JASPAR analysis and Dual-luciferase assay, the binding site of HNF4α to the upstream promoter of Bcl-2 was found. Taken together, AMPK attenuates brain injury after CA by activating HNF4α to target Bcl-2 to inhibit apoptosis.
Preliminary insights from hydrological field monitoring for the evaluation of landslide triggering conditions over large areas
Authors: Schilirò Luca , Marmoni Gian Marco , Fiorucci Matteo , Pecci Massimo , Mugnozza Gabriele Scarascia 
Published: June 2023

AbstractRainfall-induced landslides represent a major threat to human activities, and thus an improved understanding of their triggering mechanisms is needed. The paper reports some preliminary inferences on this topic, based on the data recorded over a 2-year period by a multi-parametric monitoring station located on one of the slopes of the Monterosso catchment (Cinque Terre, north-western Italy). This catchment has experienced multiple, concurrent shallow landslides after intense rainfall events. After defining a soil hydraulic model through data interpretation and numerical simulations, slope stability analyses were performed to elucidate several aspects related to shallow landslide occurrence. Both long-term climate conditions and single rainfall events were simulated via physically based approaches. The findings from these simulations enabled us to assume the pattern of infiltration and quantify the impact of soil hydraulic behavior on landslide triggering conditions. In this regard, various analyses were carried out on the same triggering event both at local scale and in the overall catchment, with a view to highlighting the role of initial soil moisture and soil hysteretic behavior in slope stability.
Sociodemographic factors and use of pain medication are associated with health-related quality of life: results from an adult community mental health service in Norway
Authors: Lindberg Martin Schevik , Brattmyr Martin , Lundqvist Jakob , Roos Eirik , Solem Stian , Hjemdal Odin , Havnen Audun 
Published: June 2023

Abstract
Purpose
Health-related quality of life (HRQoL) is an important aspect of mental health outcomes. There are few studies on HRQoL in heterogeneous patient populations seeking help at community mental health services. The aims of the study were to compare how HRQoL, measured by the EuroQol five dimensions with five levels (EQ-5D-5L), was distributed compared to other samples from national and international studies, and to explore what factors are associated with HRQoL.

Methods
In a cross-sectional study, 1379 Norwegian outpatients reported their HRQoL before starting treatment. Associations with demographic variables, job status, socio-economic status, and use of pain medication were examined using multiple regression analysis.

Results
Most of the sample, 70% to 90%, reported problems with usual activities, pain/discomfort, and anxiety/depression; 30% to 65% reported that these problems were of a moderate to extreme degree. Forty percent reported problems with mobility, and about 20% reported problems with self-care. The sample’s HRQoL was considerably lower than the general population, and comparable to patient-groups from specialist mental health services. Originating from a developing country, lower level of education, lower yearly household income, being on sick leave or unemployed, and using pain medication were associated with lower HRQoL. Age, gender, and relationship status were not associated with HRQoL. This is the first study to simultaneously examine the unique contribution of these variables in one study.

Conclusion
The most impacted domains of HRQoL were pain/discomfort, anxiety/depression, and usual activities. Lower HRQoL was associated with several socio-demographic factors and use of pain medication. These findings might have clinical implications and suggest that mental health professionals should routinely measure HRQoL in addition to symptom severity, to identify areas that should be targeted to improve HRQoL.
No Evidence for Absence of Solar Dynamo Synchronization
Authors: Stefani F. , Beer J. , Weier T. 
Published: June 2023

AbstractThe old question of whether the solar dynamo is synchronized by the tidal forces of the orbiting planets has recently received renewed interest, both from the viewpoint of historical data analysis and in terms of theoretical and numerical modeling. We aim to contribute to the solution of this longstanding puzzle by analyzing cosmogenic radionuclide data from the last millennium. We reconsider a recent time series of 14C-inferred sunspot data and compare the resulting cycle minima and maxima with the corresponding conventional series down to 1610 A.D., enhanced by Schove’s data before that time. We find that, despite recent claims to the contrary, the 14C-inferred sunspot data are well compatible with a synchronized solar dynamo, exhibiting a relatively phase-stable period of 11.07 years, which points to a synchronizing role of the spring tides of the Venus-Earth-Jupiter system.
Assessing the Mobilization of Trapped Mass of Emulsions Flowing in an Idealized Pore Using the Lattice Boltzmann Method
Authors: Miliani Stefano , La Rocca Michele , Montessori Andrea , Prestininzi Pietro 
Published: June 2023

AbstractIn this work, a Lattice Boltzmann model for multi-component fluids augmented with repulsive near-contact interactions is employed to simulate the dynamics of flowing emulsions within idealized pores. The model is firstly tested on experimental data of droplets’ self-assembly in diverging-converging micro-channels from literature and then used to investigate the trapping/mobilization of the dispersed phase of an emulsion in an idealized series of pores, as influenced by both the Capillary number and the solid walls wettability. Both parameters may vary as the result of an injection of surfactants, a procedure commonly adopted in soil remediation and Enhanced Oil Recovery applications. The analysis shows that the proposed model is able to reproduce correctly the experimental data and gives interesting insights on the trapping/mobilization phenomenon resulting from a modification of the flow conditions caused by the injection of surfactants.
Immunohistochemical expression of CD117/KIT, HER2, and Erβ in schistosomal and non-schistosomal urothelial carcinoma of Egyptian patients
Authors: Khalifa Sara E. 
Published: June 2023

AbstractBladder carcinoma is an endemic problem in Egypt with schistosomiasis being an additional risk factor. Due to gender disparities, Erβ investigation and its role in modulating chemosensitivity are studied. CD117/KIT expression is also considered since the emergence of the targets of the tyrosine kinase inhibitor imatinib mesylate (Gleevec). HER2 is one of the established therapeutic targets in many cancers. We aimed to investigate CD117/KIT immunoexpression in schistosomal and non-schistosomal urothelial carcinoma of Egyptian patients and its relationship with HER2 and Erβ expressions, correlating it with pertinent variables that will help to provide better treatment options of possible combined targeted and hormonal therapy that might be effective against this aggressive malignancy. Sixty cases of bladder carcinoma were tested. Depending on the schistosomiasis association status of each case, two groups have been established with 30 cases each. CD117/KIT, HER2, and ERβ immunostaining were done and correlated with clinico- immuno-pathological parameters. CD117/KIT expression was seen in 71.7% of cases that correlated significantly with schistosomiasis (P = 0.01). In addition, a positive correlation was detected between schistosomiasis association and the percentage of immunostained cells and intensity score of CD117/KIT with P = 0.027, 0.01, respectively. 30% and 61.7% of cases were positively stained with HER2 and Erβ, respectively, with no significant relation with schistosomiasis. Due to the high expression, we found further clinical trials are needed to offer individualized targeted therapeutic options in urothelial tumors using anti-CD117/KIT, HER2, and ERβ other than limited traditional chemo- and nontargeted therapies.
Febuxostat attenuates aluminum chloride-induced hepatorenal injury in rats with the impact of Nrf2, Crat, Car3, and MNK-mediated apoptosis
Authors: Sedik Ahmed A. , Hassan Soha A. , Shafey Heba I. , Khalil Wagdy K. B. , Mowaad Noha A. 
Published: June 2023

Abstract
Aluminum (Al) is a ubiquitous xenobiotic with known toxicity for both humans and animals. Our study was conducted to investigate the protective role of febuxostat (Feb) against aluminum chloride (AlCl3)-induced hepatorenal injury in rats. Hepatorenal injury was induced by oral administration of AlCl3 (40 mg/kg b.w.), for 2 months. Twenty-four male Sprague–Dawley rats were randomly allocated into four groups (six rats/group). The first group received the vehicle thought the experiment. The second group was considered as a control positive group. The third and fourth groups received oral treatment of Feb (10 mg/kg.b.w.) and (15 mg/kg.b.w.), respectively with AlCl3, concurrently for 2 months. Twenty-four hours, after the last treatment, serum biochemical, molecular, histopathology, and immunohistochemical studies were evaluated. Our findings showed that rats intoxicated with Alcl3 had disturbed biochemical picture. In addition, intoxication with AlCl3 increased oxidative stress and apoptosis, as demonstrated by an increase in malodialdeyde (MDA), carnitine o-acetyltransferase (Crat), and carbonic anhydrase (Car3) with a decrease in glutathione (GSH), MAP kinase-interacting serine/threonine kinase (MNK) and nuclear factor-erythroid 2-related factor 2 (Nrf2) mRNA expression. Furthermore, the levels of tumor necrosis factor-alpha (TNF-α) and the levels of caspase-3 were elevated with sever hepatic and renal pathological changes. Conversely, Feb (15 mg/kg.b.w.) could improve the serum biochemical indices and repressed MDA, Crat, and Car3 levels, whereas it increased GSH, MNK, and Nrf2 levels. Feb inhibited the apoptotic effect of AlCl3 in the liver and kidney by decreasing caspase-3 and TNF-α expression. The protective effect of Feb against AlCl3 toxicity was confirmed by histopathological findings. Moreover, molecular docking studies supported the anti-inflammatory effect of Feb due to its significant binding interactions with cyclooxygenase-1 (COX-1), NF-kappa-B-inducing kinase (NIK), and mitogen-activated protein kinases-p38 (MAPK-p38). The findings suggest that Feb system Feb can avert Alcl3-induced hepatotoxicity and nephrotoxicity by enhancing the antioxidant defense system, and inhibiting the inflammatory cascade and apoptosis.