bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term cisplatin nephrotoxicity after childhood cancer: a systematic review and meta-analysis
Authors: Schofield Jessica , Harcus Matthew , Pizer Barry , Jorgensen Andrea , McWilliam Stephen 
Published: September 2023

Abstract
Background
Cisplatin is a chemotherapeutic drug commonly used in the treatment of many childhood solid malignancies. It is known to cause long-term nephrotoxicity, most commonly manifesting as reduced glomerular filtration rate and hypomagnesaemia. Existing literature regarding the epidemiology of long-term nephrotoxicity in childhood cancer describes large variation in prevalence and risk factors.

Objectives
This study is to evaluate the prevalence of, and risk factors for, long-term cisplatin nephrotoxicity after treatment for childhood cancer.

Study eligibility criteria
Studies were eligible for inclusion if they: (i) evaluated participants treated with cisplatin who were diagnosed with cancer < 18 years of age; (ii) investigated any author-defined measure of nephrotoxicity; and (iii) performed this evaluation 3 or more months after cisplatin cessation. Studies whose scope was broader than this were included if appropriate subgroup analysis was performed.

Results
Prevalence of reduced glomerular filtration rate (GFR) ranged between 5.9 and 48.1%. Pooled prevalence of reduced GFR using studies with a modern consensus threshold of 90 ml/min/1.73 m2 was 29% (95% CI 0.0–58%). Prevalence of hypomagnesaemia ranged between 8.0 and 71.4%. Pooled prevalence of hypomagnesaemia was 37% (95% CI 22–51%). Substantial heterogeneity was present, with I2 statistics of 94% and 73% for reduced GFR and hypomagnesaemia respectively. All large, long-term follow-up studies described increased risk of reduced GFR with increasing cumulative cisplatin dose. Included studies varied as to whether cisplatin was a risk factor for proteinuria, and whether age was a risk factor for cisplatin nephrotoxicity.

Limitations
A wide range of study methodologies were noted which impeded analysis. No studies yielded data from developing health-care settings. No non-English studies were included, further limiting generalisability.

Conclusions
Both of the most common manifestations of long-term cisplatin nephrotoxicity have a prevalence of approximately a third, with increasing cumulative dose conferring increased risk of nephrotoxicity. Further work is needed to characterise the relationship between reduced GFR and hypomagnesaemia, investigate other risk factors and understand the interindividual variation in susceptibility to nephrotoxicity.
Evolutionary support vector regression for monitoring Poisson profiles
Authors: Yeganeh Ali , Abbasi Saddam Akber , Shongwe Sandile Charles , Malela-Majika Jean-Claude , Shadman Ali Reza 
Published: September 2023

AbstractMany researchers have shown interest in profile monitoring; however, most of the applications in this field of research are developed under the assumption of normal response variable. Little attention has been given to profile monitoring with non-normal response variables, known as general linear models which consists of two main categories (i.e., logistic and Poisson profiles). This paper aims to monitor Poisson profile monitoring problem in Phase II and develops a new robust control chart using support vector regression by incorporating some novel input features and evolutionary training algorithm. The new method is quicker in detecting out-of-control signals as compared to conventional statistical methods. Moreover, the performance of the proposed scheme is further investigated for Poisson profiles with both fixed and random explanatory variables as well as non-parametric profiles. The proposed monitoring scheme is revealed to be superior to its counterparts, including the likelihood ratio test (LRT), multivariate exponentially weighted moving average (MEWMA), LRT-EWMA and other machine learning-based schemes. The simulation results show superiority of the proposed method in profiles with fixed explanatory variables and non-parametric models in nearly all situations while it is not able to be the best in all the simulations when there are with random explanatory variables. A diagnostic method with machine learning approach is also used to identify the parameters of change in the profile. It is shown that the proposed profile diagnosis approach is able to reach acceptable results in comparison with other competitors. A real-life example in monitoring Poisson profiles is also provided to illustrate the implementation of the proposed charting scheme.
Beitrag naturbasierter Lösungen zur Kreislaufwirtschaft in Städten – Die COST Action Circular City
Authors: Langergraber Günter , Canet Marti Alba , Pucher Bernhard 
Published: September 2023

ZusammenfassungIm Rahmen des EU-finanzierten Netzwerkprojekts COST Action Circular City wurde die Anwendung von naturbasierten Lösungen (NBS) im Kontext der Kreislaufwirtschaft in Städten untersucht. Dabei steht die Minimierung des Inputs von notwendigen Ressourcen wie Wasser, Nährstoffen, Biomasse, lebenden Organismen und Energie im Vordergrund. Die Hauptergebnisse sind das Circular-City-Rahmenwerk (Framework) und dessen grafische Umsetzung als Online-Toolbox. Das Rahmenwerk beschreibt einen Technologie-Katalog mit NBS-Einheiten und -Interventionen, mit denen die Bewältigung der urbanen Herausforderungen der Kreislaufwirtschaft möglich ist, sowie eine Methodik zur Definition von Input- und Output-Ressourcenströmen. Das Online-Tool besteht aus einer Toolbox sowie einem Tool zur Quantifizierung der Ressourcenströme. Meist wird bei der Implementierung von NBS deren Potenzial zur Förderung der Multifunktionalität in der Regel nicht voll ausgeschöpft. Eine sektorübergreifende Zusammenarbeit ist dafür im Planungsprozess unerlässlich. Zirkuläres Denken unterstützt dabei eine bessere und multifunktionale Planung mehrerer städtischer Herausforderungen.
Self-efficacy, motivation, and habits: psychological correlates of exercise among women with breast cancer
Authors: Jones Tamara L. , Edbrooke Lara , Rawstorn Jonathan C. , Hayes Sandra C. , Maddison Ralph , Denehy Linda , Short Camille E. 
Published: September 2023

Abstract
Purpose
The purpose of this analysis was to explore associations between exercise behaviour among breast cancer survivors and three behavioural constructs from distinct theories: self-efficacy from social cognitive theory, motivation from self-determination theory, and habits from habit theory.

Methods
Breast cancer survivors (n = 204) completed a cross-sectional survey that collected demographic and disease characteristics, exercise levels, and self-efficacy, motivation, and habits. Multivariable linear regression models were used to identify constructs associated with total activity and resistance training.

Results
Participants were a mean (SD) age of 57.3 (10.8) years and most were diagnosed with early-stage disease (72%) and engaged in sufficient levels of total activity (94%), though only 45% completed ≥ 2 resistance training sessions/week. Identified motivation (ꞵ[95% CI] = 7.6 [3.9–11.3]) and habits (ꞵ[95% CI] = 4.4 [1.4–7.4]) were significantly associated with total activity (as were body mass index and disease stage), whilst identified motivation (ꞵ[95% CI] = 0.6 [0.3–0.9]) and coping self-efficacy (ꞵ[95% CI] = 0.02 [< 0.01–0.03]) were significantly associated with resistance training. The models explained 27% and 16% of variance in total activity and resistance training behaviour, respectively.

Conclusion
Results suggest that incorporating strategies that support identified motivation, habits, and coping self-efficacy in future interventions could promote increased exercise behaviour among breast cancer populations. Future longitudinal research should examine associations with exercise in a more representative, population-based sample.
An ultrasensitive micropillar-enabled acoustic wave (μPAW) microdevice for real-time viscosity measurement
Authors: Esfahani Ilia Chiniforooshan , Ji Siqi , Alamgir Tehrani Nastaran , Sun Hongwei 
Published: September 2023

AbstractViscosity measurement has recently captured considerable attention due to its wide range of applications in fields such as pharmacy, food industry, cosmetic industry, and biomedical diagnostics. Acoustic wave sensors such as quartz crystal microbalance (QCM) are well-known mass sensors that also show their capability in measuring liquid viscosity. However, the challenges for QCM-based viscosity measurement devices lie in their low sensitivity and unstable response. Herein, we report an ultrasensitive micropillar-enabled acoustic wave (μPAW) viscometer by fabricating well-defined polymethyl methacrylate (PMMA) micropillars on a QCM substrate to achieve ultrahigh sensitivity for liquid viscosity with a stable response thanks to a unique vibration coupling between the micropillar and QCM substrate. The μPAW based viscometer shows a 20-fold improvement in the measurement sensitivity over traditional QCM viscometers and achieved an excellent limit of detection (LOD) while measuring the viscosity of sucrose liquid as low as 0.054 wt%. The microdevice developed in this work is a promising tool for the viscosity measurement of liquids.
Beneficial and harmful effects of physical activity on care-seeking for low back pain: the AUTBACK study
Authors: Ho E. K. , Ferreira M. L. , Bauman A. , Carvalho-e-Silva AP , Pinheiro M. B. , Hübscher M. , Calais-Ferreira L. , Simic M. , Ferreira P. H. 
Published: September 2023

Abstract
Purpose
People who seek more care for low back pain (LBP) tend to experience poorer recovery (e.g. higher pain and disability levels). Understanding the factors associated with care-seeking for LBP might improve patient outcomes and potentially alleviate the burden of LBP on global health systems. This study aimed to investigate the relationship between different intensities, volumes, and domains of physical activity and care-seeking behaviours, in people with a history of LBP.

Methods
Longitudinal data from adult twins were drawn from the AUstralian Twin BACK study. The primary outcome was the total self-reported frequency (counts) of overall utilisation of care for LBP, over 1 year. Secondary outcomes were the utilisation of health services, and the utilisation of self-management strategies, for LBP (assessed as total frequency over 1 year). Explanatory variables were device-based measures of sedentary behaviour and moderate-to-vigorous intensity physical activity, and self-reported physical workload, and work, transport, household, and leisure domain physical activity, at baseline.

Results
Data from 340 individuals were included. Median age was 56.4 years (IQR 44.9–62.3 years) and 73% of participants were female. Medium-to-high baseline volumes of sedentary behaviour were significantly associated with greater counts of overall care utilisation (IRR 1.60, 95%CI 1.04–2.44) and utilisation of self-management strategies (IRR 1.60, 95%CI 1.02–2.50) for LBP, over 1 year. Medium-to-high baseline volumes of household domain physical activity were significantly associated with greater counts of utilising self-management strategies for LBP over 1 year (IRR 1.62, 95%CI 1.04–2.53). No explanatory variables were associated with the utilisation of health services for LBP.

Conclusion
People who engage in higher baseline volumes of sedentary behaviour or physical activity in the household setting (e.g. housework, gardening, yard work, general household maintenance) utilise 1.6 times more care for LBP over 1 year. Findings suggest that higher volumes of these behaviours may be harmful for LBP. No intensities, volumes, or domains of physical activity demonstrated clear benefits for LBP. Where feasible, patients and clinicians should collaborate to screen and develop strategies to reduce engagement in sedentary behaviour or physical activity in the household setting. Contextual factors (e.g. patient symptom severity, sociocultural roles, occupational demands) should be considered when devising appropriate behaviour change strategies.
Visualization of the lenticulostriate arteries, long insular arteries, and long medullary arteries on intra-arterial computed tomography angiography with ultrahigh resolution in patients with glioma
Authors: Osada Yoshinari , Kanamori Masayuki , Osawa Shin-Ichiro , Kayano Shingo , Uchida Hiroki , Shimoda Yoshiteru , Mugikura Shunji , Tominaga Teiji , Endo Hidenori 
Published: September 2023

Abstract
Purpose
The anatomical association between the lesion and the perforating arteries supplying the pyramidal tract in insulo-opercular glioma resection should be evaluated. This study reported a novel method combining the intra-arterial administration of contrast medium and ultrahigh-resolution computed tomography angiography (UHR-IA-CTA) for visualizing the lenticulostriate arteries (LSAs), long insular arteries (LIAs), and long medullary arteries (LMAs) that supply the pyramidal tract in two patients with insulo-opercular glioma.

Methods
This method was performed by introducing a catheter to the cervical segment of the internal carotid artery. The infusion rate was set at 3 mL/s for 3 s, and the delay time from injection to scanning was determined based on the time-to-peak on angiography. On 2- and 20-mm-thick UHR-IA-CTA slab images and fusion with magnetic resonance images, the anatomical associations between the perforating arteries and the tumor and pyramidal tract were evaluated.

Results
This novel method clearly showed the relationship between the perforators that supply the pyramidal tract and tumor. It showed that LIAs and LMAs were far from the lesion but that the proximal LSAs were involved in both cases. Based on these results, subtotal resection was achieved without complications caused by injury of perforators.

Conclusion
UHR-IA-CTA can be used to visualize the LSAs, LIAs, and LMAs clearly and provide useful preoperative information for insulo-opercular glioma resection.
Does glaze firing affect the strength of advanced lithium disilicate after simulated defects?
Authors: Lu Yuqing , de Oliveira Dal Piva Amanda Maria , Tribst João Paulo Mendes , Feilzer Albert J , Kleverlaan Cornelis J 
Published: September 2023

Abstract
Objective
To study the influence of glazing on strength repair of lithium disilicate glass–ceramics after defect incorporation in different production processing phases.

Materials and methods
Bar-shaped specimens (1 × 1 × 12 mm, n = 280; 20/group) made from different lithium disilicate ceramics (IPS e.max CAD, Ivoclar, “LD” or advanced lithium disilicate CEREC Tessera, Dentsply Sirona, “ALD”) were exposed to 7 different protocols: crystallized without (c) and with glaze layer (cg), with a defect incorporated before crystallization without (ic) and with glaze layer (icg), with a defect after crystallization without (ci) or with glaze layer (cig), and defect incorporated after the glaze layer (cgi). The flexural strength was determined using the three-point bending test. Analysis of indented areas and fractured specimens was performed by scanning electron microscopy. Flexural strength data were evaluated by two-way ANOVA followed by Tukey tests (α = 5%).

Results
Two-way ANOVA revealed a significant influence of ceramic (p < 0.001; F = 55.45), protocol (p < 0.001; F = 56.94), and the interaction protocol*ceramic (p < 0.001; F = 13.86). Regardless of ceramics, defect incorporation as final step resulted in the worst strength, while defects introduced before crystallization did not reduce strength. Glaze firing after defect incorporation led to strength repair for ALD, whereas such an effect was not evident for LD.

Conclusions
The advanced lithium disilicate must receive a glaze layer to achieve its highest strength. Defects incorporated in the pre-crystallized stage can be healed during crystallization. Defects should not be incorporated after glazing.

Clinical relevance
Clinical adjustments should be performed on pre-crystallized or crystalized restorations that receive a glazer layer afterwards.
A national-scale assessment of land use change in peatlands between 1989 and 2020 using Landsat data and Google Earth Engine—a case study of Ireland
Authors: Habib Wahaj , Connolly John 
Published: September 2023

AbstractOver the centuries, anthropogenic pressure has severely impacted peatlands on the European continent. Peatlands cover ~ 21% (1.46 Mha) of Ireland’s land surface, but 85% have been degraded due to management activities (land use). Ireland needs to meet its 2030 climate energy framework targets related to greenhouse gas (GHG) emissions from land use, land use change and forestry, including wetlands. Despite Ireland’s voluntary decision to include peatlands in this system in 2020, information on land use activities and associated GHG emissions from peatlands is lacking. This study strives to fill this information gap by using Landsat (5, 8) data with Google Earth Engine and machine learning to examine and quantify land use on Irish peatlands across three time periods: 1990, 2005 and 2019. Four peatland land use classes were mapped and assessed: industrial peat extraction, forestry, grassland and residual peatland. The overall accuracy of the classification was 86% and 85% for the 2005 and 2019 maps, respectively. The accuracy of the 1990 dataset could not be assessed due to the unavailability of high-resolution reference data. The results indicate that extensive management activities have taken place in peatlands over the past three decades, which may have negative impacts on its ecological integrity and the many ecosystem services provided. By utilising cloud computing, temporal mosaicking and Landsat data, this study developed a robust methodology that overcomes cloud contamination and produces the first peatland land use maps of Ireland with wall-to-wall coverage. This has the potential for regional and global applications, providing maps that could help understand unsustainable management practices on peatlands and the impact on GHG emissions.
Targeting the microenvironment in the treatment of arteriovenous malformations
Authors: Seebauer Caroline T. , Wiens Benedikt , Hintschich Constantin A. , Platz Batista da Silva Natascha , Evert Katja , Haubner Frank , Kapp Friedrich G. , Wendl Christina , Renner Kathrin , Bohr Christopher , Kühnel Thomas , Vielsmeier Veronika 
Published: September 2023

AbstractExtracranial arteriovenous malformations (AVMs) are regarded as rare diseases and are prone to complications such as pain, bleeding, relentless growth, and high volume of shunted blood. Due to the high vascular pressure endothelial cells of AVMs are exposed to mechanical stress. To control symptoms and lesion growth pharmacological treatment strategies are urgently needed in addition to surgery and interventional radiology. AVM cells were isolated from three patients and exposed to cyclic mechanical stretching for 24 h. Thalidomide and bevacizumab, both VEGF inhibitors, were tested for their ability to prevent the formation of circular networks and proliferation of CD31+ endothelial AVM cells. Furthermore, the effect of thalidomide and bevacizumab on stretched endothelial AVM cells was evaluated. In response to mechanical stress, VEGF gene and protein expression increased in patient AVM endothelial cells. Thalidomide and bevacizumab reduced endothelial AVM cell proliferation. Bevacizumab inhibited circular network formation of endothelial AVM cells and lowered VEGF gene and protein expression, even though the cells were exposed to mechanical stress. With promising in vitro results, bevacizumab was used to treat three patients with unresectable AVMs or to prevent regrowth after incomplete resection. Bevacizumab controlled bleeding, pulsation, and pain over the follow up of eight months with no patient-reported side effects. Overall, mechanical stress increases VEGF expression in the microenvironment of AVM cells. The monoclonal VEGF antibody bevacizumab alleviates this effect, prevents circular network formation and proliferation of AVM endothelial cells in vitro. The clinical application of bevacizumab in AVM treatment demonstrates effective symptom control with no side effects.
Graphical abstract
Mechanical stress increases VEGF expression in endothelial AVM cells, possibly causing the VEGF upregulation in the microenvironment of AVM cells. The resulting RAS/RAF/MEK/ERK signaling in leads to progression of fast-flow malformations. The monoclonal VEGF-A antibody bevacizumab alleviates this effect, prevents circular network formation and proliferation of AVM endothelial cells in vitro. Sporadically occurring slow-flow malformations (LMs, VMs) have mutations in TEK or PIK3CA. TEK encodes the endothelial receptor tyrosine kinase TIE2. Sporadic extracranial fast-flow malformations (AVMs) show mutations in KRAS, BRAF and MAP2K1, which encodes the dual specificity mitogen-activated protein kinase MEK1. Combined targeting of the molecular causes of the disease could be key to achieve symptom control and reduce lesion growth. Orange: gain-of-function; Blue, circled with orange: enhanced signaling.
Linking assessment to real life practice – comparing work based assessments and objective structured clinical examinations using mystery shopping
Authors: Lim Angelina , Krishnan Sunanthiny , Singh Harjit , Furletti Simon , Sarkar Mahbub , Stewart Derek , Malone Daniel 
Published: September 2023

AbstractObjective Structured Clinical Examinations (OSCEs) and Work Based Assessments (WBAs) are the mainstays of assessing clinical competency in health professions’ education. Underpinned by the extrapolation inference in Kane’s Validity Framework, the purpose of this study is to determine whether OSCEs translate to real life performance by comparing students’ OSCE performance to their performance in real-life (as a WBA) using the same clinical scenario, and to understand factors that affect students’ performance. A sequential explanatory mixed methods approach where a grade comparison between students’ performance in their OSCE and WBA was performed. Students were third year pharmacy undergraduates on placement at a community pharmacy in 2022. The WBA was conducted by a simulated patient, unbeknownst to students and indistinguishable from a genuine patient, visiting the pharmacy asking for health advice. The simulated patient was referred to as a ‘mystery shopper’ and the process to ‘mystery shopping’ in this manuscript. Community pharmacy is an ideal setting for real-time observation and mystery shopping as staff can be accessed without appointment. The students’ provision of care and clinical knowledge was assessed by the mystery shopper using the same clinical checklist the student was assessed from in the OSCE. Students who had the WBA conducted were then invited to participate in semi-structured interviews to discuss their experiences in both settings. Overall, 92 mystery shopper (WBA) visits with students were conducted and 36 follow-up interviews were completed. The median WBA score was 41.7% [IQR 28.3] and significantly lower compared to the OSCE score 80.9% [IQR 19.0] in all participants (p < 0.001). Interviews revealed students knew they did not perform as well in the WBA compared to their OSCE, but reflected that they still need OSCEs to prepare them to manage real-life patients. Many students related their performance to how they perceived their role in OSCEs versus WBAs, and that OSCEs allowed them more autonomy to manage the patient as opposed to an unfamiliar workplace. As suggested by the activity theory, the performance of the student can be driven by their motivation which differed in the two contexts.