bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unravelling the complex sub-ice geology of the Wilkes Subglacial Basin region of East Antarctica from marine sediment provenance analyses
Authors: Pandey Mayuri , Pant Naresh Chandra , Arora Devsamridhi , Ferraccioli Fausto , Gupta Rashmi , Joshi Sonalika 
Published: July 2023

AbstractDeciphering the sub-ice geology in the Wilkes Subglacial Basin region is important for understanding solid earth-ice sheet evolution and for assessing geological ties between East Antarctica and formerly contiguous Australia. We analyse marine sediment samples derived from drill site U1359 of Integrated Oceanic Drilling Program Expedition 318. Our study reports for the first time that the inland sediment source area comprises a complex mafic igneous terrain and a metamorphosed Precambrian subglacial basement. Pyroxene geochemical analyses confirm the presence of tholeiitic to calc-alkaline basalts. The high-grade part of the subglacial terrain contains upper amphibolite to granulite facies rocks that are comparable to Archaean to Palaeoproterozoic rocks exposed in the Terre Adélie Craton and the formerly adjacent Gawler Craton in Australia. Chemical Th-U-total Pb isochron method (CHIME) ages extracted from a subhedral monazite grain associated with the low-grade biotite-muscovite schist rock fragment provide a unimodal age of 799 ± 13 Ma. Rare occurrences of 800 Ma age in the Terre Adélie Craton and/or George V Coast provide evidence for the presence of at least one late Neoproterozoic magmato-metamorphic event in the interior of Wilkes Land. The affinity of the unexposed geological domains of Wilkes Land, East Antarctica, with their Australian counterparts is discussed in the context of the Rodinia supercontinent.
Post-natal muscle growth and protein turnover: a narrative review of current understanding
Authors: Millward D. Joe 
Published: July 2023

AbstractA model explaining the dietary-protein-driven post-natal skeletal muscle growth and protein turnover in the rat is updated, and the mechanisms involved are described, in this narrative review. Dietary protein controls both bone length and muscle growth, which are interrelated through mechanotransduction mechanisms with muscle growth induced both from stretching subsequent to bone length growth and from internal work against gravity. This induces satellite cell activation, myogenesis and remodelling of the extracellular matrix, establishing a growth capacity for myofibre length and cross-sectional area. Protein deposition within this capacity is enabled by adequate dietary protein and other key nutrients. After briefly reviewing the experimental animal origins of the growth model, key concepts and processes important for growth are reviewed. These include the growth in number and size of the myonuclear domain, satellite cell activity during post-natal development and the autocrine/paracrine action of IGF-1. Regulatory and signalling pathways reviewed include developmental mechanotransduction, signalling through the insulin/IGF-1–PI3K–Akt and the Ras–MAPK pathways in the myofibre and during mechanotransduction of satellite cells. Likely pathways activated by maximal-intensity muscle contractions are highlighted and the regulation of the capacity for protein synthesis in terms of ribosome assembly and the translational regulation of 5-TOPmRNA classes by mTORC1 and LARP1 are discussed. Evidence for and potential mechanisms by which volume limitation of muscle growth can occur which would limit protein deposition within the myofibre are reviewed. An understanding of how muscle growth is achieved allows better nutritional management of its growth in health and disease.
Affective Interruptions: Political Collectivity in Halftime
Authors: Jennex Craig 
Published: July 2023

AbstractIn this article, I analyze a rhythmic device in musical theater performance that is often used but rarely discussed: The sudden break into halftime. Breaking into halftime—a rhythmic shift that is performed and perceived as occurring at half the tempo (or speed) of the groove in preceding and subsequent sections—has the effect of abruptly stretching out and slowing down musical temporality. With a break into halftime, a song's groove is suddenly broader, more open, and expansive. When accompanied by lyrics, the move suggests deliberateness, calls attention to the lyrical address, and invites a considered response from the listener. It is a musical device akin to drastically slowing down a spoken cadence to ensure that the listener is fully grasping the significance of one's words. With or without lyrics, this temporal disruption has a powerful effect on listeners’ bodies as, suddenly, the established timing of one's musical experience is disrupted and immediately set to half the speed of the previous pace. By analyzing the use of halftime in three filmed musicals—Newsies, Rent, and the Rocky Horror Picture Show—I show how the rhythmic device carries with it social coding of solidarity and collective power among queer, marginalized, and/or otherwise outcast individuals and ultimately alters the broader narrative of the shows. Ultimately, I articulate how halftime serves to queer time and forge collective action, allowing us to reimagine what sort of politics, formations, collectives, and futures are possible.
Remote Sensing Soil Freeze‐Thaw Status and North American N2O Emissions From a Regional Inversion
Authors: Nevison Cynthia , Lan Xin , Ogle Stephen M. 
Published: July 2023

AbstractNorth American nitrous oxide (N2O) emissions over 2011–2018 are estimated using the CarbonTracker‐Lagrange regional inversion framework. Emissions are strongest in the Midwestern corn/soybean belt and display a distinct dual maxima seasonal pattern. The first maximum occurs in late winter/early spring, suggestive of freeze‐thaw (FT) effects on denitrification rates and associated N2O emissions. The second maximum occurs in late spring/early summer, consistent with a growing season nitrogen fertilizer‐driven source, although fertilizer applied in late fall may contribute to the FT pulse as well. Interannual variability in the first maximum correlates significantly to soil freeze thaw status derived from remote sensing data. A requisite frozen period in the preceding early winter appears necessary to create conditions for the N2O pulse after thawing. The FT pulse is a prominent feature of the annual cycle in Canadian cropland, where it may be of comparable magnitude to growing season emissions. In contrast, the growing season peak in N2O dominates the FT peak in the Midwestern Corn‐Soybean region of the United States.
Influences Driving and Limiting the Efficacy of Ice Segregation in Alpine Rocks
Authors: Mayer T. , Eppes M. , Draebing D. 
Published: July 2023

AbstractRockwall erosion by rockfall is largely controlled by frost weathering in high alpine environments. As alpine rock types are characterized by crack‐dominated porosity and high rock strength, frost cracking observations from low strength and grain supported pore‐space rocks cannot be transferred. Here, we conducted laboratory experiments on Wetterstein limestone samples with different initial crack density and saturation to test their influence on frost cracking efficacy. We exposed rocks to real‐rockwall freezing conditions and monitored acoustic emissions as a proxy for cracking. To differentiate triggers of observed cracking, we modeled ice pressure and thermal stresses. Our results show initial full saturation is not a singular prerequisite for frost cracking. We also observe higher cracking rates in less‐fractured rock. Finally, we find that the temperature threshold for frost cracking in alpine rocks falls below −7°C. Thus, colder, north‐exposed rock faces in the Alps likely experience more frost cracking than southern‐facing counterparts.
SOX17-mediated LPAR4 expression plays a pivotal role in cardiac development and regeneration after myocardial infarction
Authors: Lee Jin-Woo , Lee Choon-Soo , Son HyunJu , Lee Jaewon , Kang Minjun , Chai Jinho , Cho Hyun-Jai , Kim Hyo-Soo 
Published: July 2023

AbstractLysophosphatidic acid receptor 4 (LPAR4) exhibits transient expression at the cardiac progenitor stage during pluripotent stem cell (PSC)-derived cardiac differentiation. Using RNA sequencing, promoter analyses, and a loss-of-function study in human PSCs, we discovered that SRY-box transcription factor 17 (SOX17) is an essential upstream factor of LPAR4 during cardiac differentiation. We conducted mouse embryo analyses to further verify our human PSC in vitro findings and confirmed the transient and sequential expression of SOX17 and LPAR4 during in vivo cardiac development. In an adult bone marrow transplantation model using LPAR4 promoter-driven GFP cells, we observed two LPAR4+ cell types in the heart following myocardial infarction (MI). Cardiac differentiation potential was shown in heart-resident LPAR4+ cells, which are SOX17+, but not bone marrow-derived infiltrated LPAR4+ cells. Furthermore, we tested various strategies to enhance cardiac repair through the regulation of downstream signals of LPAR4. During the early stages following MI, the downstream inhibition of LPAR4 by a p38 mitogen-activated protein kinase (p38 MAPK) blocker improved cardiac function and reduced fibrotic scarring compared to that observed following LPAR4 stimulation. These findings improve our understanding of heart development and suggest novel therapeutic strategies that enhance repair and regeneration after injury by modulating LPAR4 signaling.
LY6D is crucial for lipid accumulation and inflammation in nonalcoholic fatty liver disease
Authors: Lee Jibeom , Kim Hyeonhui , Kang Yun-Won , Kim Yumin , Park Moon-young , Song Ji-Hong , Jo Yunju , Dao Tam , Ryu Dongryeol , Lee Junguee , Oh Chang-Myung , Park Sangkyu 
Published: July 2023

AbstractNonalcoholic fatty liver disease (NAFLD) is a serious metabolic disorder characterized by excess fat accumulation in the liver. Over the past decade, NAFLD prevalence and incidence have risen globally. There are currently no effective licensed drugs for its treatment. Thus, further study is required to identify new targets for NAFLD prevention and treatment. In this study, we fed C57BL6/J mice one of three diets, a standard chow diet, high-sucrose diet, or high-fat diet, and then characterized them. The mice fed a high-sucrose diet had more severely compacted macrovesicular and microvesicular lipid droplets than those in the other groups. Mouse liver transcriptome analysis identified lymphocyte antigen 6 family member D (Ly6d) as a key regulator of hepatic steatosis and the inflammatory response. Data from the Genotype-Tissue Expression project database showed that individuals with high liver Ly6d expression had more severe NAFLD histology than those with low liver Ly6d expression. In AML12 mouse hepatocytes, Ly6d overexpression increased lipid accumulation, while Ly6d knockdown decreased lipid accumulation. Inhibition of Ly6d ameliorated hepatic steatosis in a diet-induced NAFLD mouse model. Western blot analysis showed that Ly6d phosphorylated and activated ATP citrate lyase, which is a key enzyme in de novo lipogenesis. In addition, RNA- and ATAC-sequencing analyses revealed that Ly6d drives NAFLD progression by causing genetic and epigenetic changes. In conclusion, Ly6d is responsible for the regulation of lipid metabolism, and inhibiting Ly6d can prevent diet-induced steatosis in the liver. These findings highlight Ly6d as a novel therapeutic target for NAFLD.
Arginine 65 methylation of Neurogenin 3 by PRMT1 is required for pancreatic endocrine development of hESCs
Authors: Cho Gahyang , Hyun Kwangbeom , Choi Jieun , Shin Eunji , Kim Bumsoo , Kim Hail , Kim Jaehoon , Han Yong-Mahn 
Published: July 2023

AbstractNeurogenin 3 (NGN3) is a key transcription factor in the cell fate determination of endocrine progenitors (EPs) in the developing pancreas. Previous studies have shown that the stability and activity of NGN3 are regulated by phosphorylation. However, the role of NGN3 methylation is poorly understood. Here, we report that protein arginine methyltransferase-1 (PRMT1)-mediated arginine 65 methylation of NGN3 is required for the pancreatic endocrine development of human embryonic stem cells (hESCs) in vitro. We found that inducible PRMT1-knockout (P-iKO) hESCs did not differentiate from EPs into endocrine cells (ECs) in the presence of doxycycline. Loss of PRMT1 caused NGN3 accumulation in the cytoplasm of EPs and decreased the transcriptional activity of NGN3. We found that PRMT1 specifically methylates NGN3 arginine 65 and that this modification is a prerequisite for ubiquitin-mediated degradation. Our findings demonstrate that arginine 65 methylation of NGN3 is a key molecular switch in hESCs permitting their differentiation into pancreatic ECs.
High-performance broadband flexible photodetector based on Gd3Fe5O12-assisted double van der Waals heterojunctions
Authors: Zhang Ze , Ji Peirui , Li Shaobo , Wang Fei , He Shengmei , Cheng Yiwei , Zhao Shuhao , Li Kaili , Wang Xiaomin , Wang Yu , Yang Shuming 
Published: July 2023

AbstractFlexible photodetectors are fundamental components for developing wearable systems, which can be widely used for medical detection, environmental monitoring and flexible imaging. However, compared with 3D materials, low-dimensional materials have degraded performance, a key challenge for current flexible photodetectors. Here, a high-performance broadband photodetector has been proposed and fabricated. By combining the high mobility of graphene (Gr) with the strong light–matter interactions of single-walled carbon nanotubes (SWCNTs) and molybdenum disulfide (MoS2), the flexible photodetector exhibits a greatly improved photoresponse covering the visible to near-infrared range. Additionally, a thin layer of gadolinium iron garnet (Gd3Fe5O12, GdlG) film is introduced to improve the interface of the double van der Waals heterojunctions to reduce the dark current. The SWCNT/GdIG/Gr/GdIG/MoS2 flexible photodetector exhibits a high photoresponsivity of 47.375 A/W and a high detectivity of 1.952 × 1012 Jones at 450 nm, a high photoresponsivity of 109.311 A/W and a high detectivity of 4.504 × 1012 Jones at 1080 nm, and good mechanical stability at room temperature. This work demonstrates the good capacity of GdIG-assisted double van der Waals heterojunctions on flexible substrates and provides a new solution for constructing high-performance flexible photodetectors.
A PPP-type pseudophosphatase is required for the maintenance of basal complex integrity in Plasmodium falciparum
Authors: Morano Alexander A. , Rudlaff Rachel M. , Dvorin Jeffrey D. 
Published: July 2023

AbstractDuring its asexual blood stage, P. falciparum replicates via schizogony, wherein dozens of daughter cells are formed within a single parent. The basal complex, a contractile ring that separates daughter cells, is critical for schizogony. In this study, we identify a Plasmodium basal complex protein essential for basal complex maintenance. Using multiple microscopy techniques, we demonstrate that PfPPP8 is required for uniform basal complex expansion and maintenance of its integrity. We characterize PfPPP8 as the founding member of a novel family of pseudophosphatases with homologs in other Apicomplexan parasites. By co-immunoprecipitation, we identify two additional new basal complex proteins. We characterize the unique temporal localizations of these new basal complex proteins (late-arriving) and of PfPPP8 (early-departing). In this work, we identify a novel basal complex protein, determine its specific role in segmentation, identify a new pseudophosphatase family, and establish that the P. falciparum basal complex is a dynamic structure.
Anomalous electronic transport in high-mobility Corbino rings
Authors: Vijayakrishnan Sujatha , Poitevin F. , Yu Oulin , Berkson-Korenberg Z. , Petrescu M. , Lilly M. P. , Szkopek T. , Agarwal Kartiek , West K. W. , Pfeiffer L. N. , Gervais G. 
Published: July 2023

AbstractWe report low-temperature electronic transport measurements performed in two multi-terminal Corbino samples formed in GaAs/Al-GaAs two-dimensional electron gases (2DEG) with both ultra-high electron mobility ( ≳ 20 × 106 cm2/ Vs) and with distinct electron density of 1.7 and 3.6 × 1011 cm−2. In both Corbino samples, a non-monotonic behavior is observed in the temperature dependence of the resistance below 1 K. Surprisingly, a sharp decrease in resistance is observed with increasing temperature in the sample with lower electron density, whereas an opposite behavior is observed in the sample with higher density. To investigate further, transport measurements were performed in large van der Pauw samples having identical heterostructures, and as expected they exhibit resistivity that is monotonic with temperature. Finally, we discuss the results in terms of various lengthscales leading to ballistic and hydrodynamic electronic transport, as well as a possible Gurzhi effect.
Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens
Authors: Barbosa Inês A. M. , Gopalakrishnan Rajaraman , Mercan Samuele , Mourikis Thanos P. , Martin Typhaine , Wengert Simon , Sheng Caibin , Ji Fei , Lopes Rui , Knehr Judith , Altorfer Marc , Lindeman Alicia , Russ Carsten , Naumann Ulrike , Golji Javad , Sprouffske Kathleen , Barys Louise , Tordella Luca , Schübeler Dirk , Schmelzle Tobias , Galli Giorgio G. 
Published: July 2023

AbstractYAP is a key transcriptional co-activator of TEADs, it regulates cell growth and is frequently activated in cancer. In Malignant Pleural Mesothelioma (MPM), YAP is activated by loss-of-function mutations in upstream components of the Hippo pathway, while, in Uveal Melanoma (UM), YAP is activated in a Hippo-independent manner. To date, it is unclear if and how the different oncogenic lesions activating YAP impact its oncogenic program, which is particularly relevant for designing selective anti-cancer therapies. Here we show that, despite YAP being essential in both MPM and UM, its interaction with TEAD is unexpectedly dispensable in UM, limiting the applicability of TEAD inhibitors in this cancer type. Systematic functional interrogation of YAP regulatory elements in both cancer types reveals convergent regulation of broad oncogenic drivers in both MPM and UM, but also strikingly selective programs. Our work reveals unanticipated lineage-specific features of the YAP regulatory network that provide important insights to guide the design of tailored therapeutic strategies to inhibit YAP signaling across different cancer types.
Rapid planning and analysis of high-throughput experiment arrays for reaction discovery
Authors: Mahjour Babak , Zhang Rui , Shen Yuning , McGrath Andrew , Zhao Ruheng , Mohamed Osama G. , Lin Yingfu , Zhang Zirong , Douthwaite James L. , Tripathi Ashootosh , Cernak Tim 
Published: July 2023

AbstractHigh-throughput experimentation (HTE) is an increasingly important tool in reaction discovery. While the hardware for running HTE in the chemical laboratory has evolved significantly in recent years, there remains a need for software solutions to navigate data-rich experiments. Here we have developed phactor™, a software that facilitates the performance and analysis of HTE in a chemical laboratory. phactor™ allows experimentalists to rapidly design arrays of chemical reactions or direct-to-biology experiments in 24, 96, 384, or 1,536 wellplates. Users can access online reagent data, such as a chemical inventory, to virtually populate wells with experiments and produce instructions to perform the reaction array manually, or with the assistance of a liquid handling robot. After completion of the reaction array, analytical results can be uploaded for facile evaluation, and to guide the next series of experiments. All chemical data, metadata, and results are stored in machine-readable formats that are readily translatable to various software. We also demonstrate the use of phactor™ in the discovery of several chemistries, including the identification of a low micromolar inhibitor of the SARS-CoV-2 main protease. Furthermore, phactor™ has been made available for free academic use in 24- and 96-well formats via an online interface.
Stratospheric water vapor affecting atmospheric circulation
Authors: Charlesworth Edward , Plöger Felix , Birner Thomas , Baikhadzhaev Rasul , Abalos Marta , Abraham Nathan Luke , Akiyoshi Hideharu , Bekki Slimane , Dennison Fraser , Jöckel Patrick , Keeble James , Kinnison Doug , Morgenstern Olaf , Plummer David , Rozanov Eugene , Strode Sarah , Zeng Guang , Egorova Tatiana , Riese Martin 
Published: July 2023

AbstractWater vapor plays an important role in many aspects of the climate system, by affecting radiation, cloud formation, atmospheric chemistry and dynamics. Even the low stratospheric water vapor content provides an important climate feedback, but current climate models show a substantial moist bias in the lowermost stratosphere. Here we report crucial sensitivity of the atmospheric circulation in the stratosphere and troposphere to the abundance of water vapor in the lowermost stratosphere. We show from a mechanistic climate model experiment and inter-model variability that lowermost stratospheric water vapor decreases local temperatures, and thereby causes an upward and poleward shift of subtropical jets, a strengthening of the stratospheric circulation, a poleward shift of the tropospheric eddy-driven jet and regional climate impacts. The mechanistic model experiment in combination with atmospheric observations further shows that the prevailing moist bias in current models is likely caused by the transport scheme, and can be alleviated by employing a less diffusive Lagrangian scheme. The related effects on atmospheric circulation are of similar magnitude as climate change effects. Hence, lowermost stratospheric water vapor exerts a first order effect on atmospheric circulation and improving its representation in models offers promising prospects for future research.
Electronic transport driven by collective light-matter coupled states in a quantum device
Authors: Pisani Francesco , Gacemi Djamal , Vasanelli Angela , Li Lianhe , Davies Alexander Giles , Linfield Edmund , Sirtori Carlo , Todorov Yanko 
Published: July 2023

AbstractIn the majority of optoelectronic devices, emission and absorption of light are considered as perturbative phenomena. Recently, a regime of highly non-perturbative interaction, ultra-strong light-matter coupling, has attracted considerable attention, as it has led to changes in the fundamental properties of materials such as electrical conductivity, rate of chemical reactions, topological order, and non-linear susceptibility. Here, we explore a quantum infrared detector operating in the ultra-strong light-matter coupling regime driven by collective electronic excitations, where the renormalized polariton states are strongly detuned from the bare electronic transitions. Our experiments are corroborated by microscopic quantum theory that solves the problem of calculating the fermionic transport in the presence of strong collective electronic effects. These findings open a new way of conceiving optoelectronic devices based on the coherent interaction between electrons and photons allowing, for example, the optimization of quantum cascade detectors operating in the regime of strongly non-perturbative coupling with light.