bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uaigneas
Authors: Stephens Olan Andrew 
Published: March 2023

Abstract
This essay is a reflection on the Irish word uaigneas, often translated into ‘loneliness’ or ‘solitude’, but closer in meaning to ‘away-from-ness’ or ‘without-ness’ (my own translation). Considering the impact of Beckett’s settings and subjects on my performance practice as an artist and musician working within the Irish landscape and with the Irish language, and thinking about rurality as a possible site for performance, I reflect on the possibility that within the Irish language and Beckett’s writing there are similarly embodied and spectral experiences of place.
“You Know What She Died of, Mother Pegg? Of Darkness …”
Authors: Bird Dúnlaith 
Published: March 2023

Abstract
This article examines the Shannon Scheme, which involved the construction of the largest hydroelectric dam in Europe from 1925, and the subsequent Rural Electrification Scheme (RES) not just as defining projects of the modern Irish State, but as social watersheds of the twentieth century that had a complex and wide-ranging influence on artists including Seán Keating and Samuel Beckett. The article considers the intertwining of art and electricity in the artistic responses to the Scheme and the RES, Irish electrification’s political and social resonances, and the extent to which Beckett’s plays, particularly Endgame, can be read as ‘electric’ works.
“Work-in-Progress”
Authors: Graham-Dixon Celia 
Published: March 2023

Abstract
Deriving from the original 1976 theatre production, the 1990 television version of Footfalls has garnered little to no critical attention in and of itself. Seeking to redress this omission, this article argues that Footfalls on screen is a crucial document of the original production and introduces aesthetic and affective qualities that enhance our understanding of the play. Working with a DVD copy of a VHS recording of the play from its original broadcast on television, this article parses out the relationship between the spectral materiality of this recording and the ideas of spectrality, authorship and subjectivity that are central to the play.
Beckett sa Chreig: Laethanta Sona
Authors: Scaife Sarah Jane 
Published: March 2023

Abstract
This article provides a short introduction to a theatre project entitled Beckett sa Chreig: Laethanta Sona (Beckett in the Rock: Happy Days), which breaks the boundaries of the traditional ‘Beckett space’. The project was a collaboration between the landscape, language and people of Inis Oírr, Samuel Beckett and Company SJ, and involved Mícheál Ó Conghaile’s translation of Happy Days into Irish (as Laethanta Sona) and its performance by Bríd Ní Neachtain. The set, built by local stone masons, was immersed in the landscape of Inis Oírr, the westernmost island of Ireland, arising sculpturally from the flaggy rock of a stone field, surrounded by the Atlantic Ocean.
Beckett et l’art minimal américain
Authors: Mougin Pascal 
Published: March 2023

Résumé
On ne peut comprendre l’importance majeure de l’œuvre de Beckett dans l’art contemporain sans revenir sur la réception de l’écrivain par les « néo-avant-gardes » américaines des années 1960 – l’art minimal en particulier –, qui marquent le moment inaugural, précisément, de l’art contemporain. Beckett fournit alors aux artistes ainsi qu’aux critiques qui les défendent une référence essentielle dans leur tentative de repenser la notion d’œuvre d’art et l’expérience esthétique contre les fondamentaux du modernisme tel que les conçoit Clement Greenberg. Pourtant, Beckett lui-même n’a semble-t-il jamais participé aux débats sur le minimalisme américain ni seulement évoqué les artistes new-yorkais. Et pour cause : les artistes de son temps qui l’intéressent sont tous des peintres de l’expressionnisme abstrait, autrement dit le courant moderniste contre lequel se positionne la nouvelle avant-garde new-yorkaise. Le hiatus est donc profond entre les références artistiques de l’écrivain et les artistes qu’il a lui-même inspirés. On s’intéressera ici à ce moment originel, qui reste largement ignoré par la critique française, ainsi qu’aux différentes lectures qui, rétrospectivement, en ont été proposées par la critique anglo-américaine des vingt dernières années.
Modeling Near-Surface Turbulence in Large-Eddy Simulations of a Tornado: An Application of Thin Boundary Layer Equations
Authors: Wang Aaron , Pan Ying , Bryan George H. , Markowski Paul M. 
Published: March 2023

Abstract
Unsteadiness and horizontal heterogeneities frequently characterize atmospheric motions, especially within convective storms, which are frequently studied using large-eddy simulations (LES). The models of near-surface turbulence employed by atmospheric LES, however, predominantly assume statistically steady and horizontally homogeneous conditions (known as the equilibrium approach). The primary objective of this work is to investigate the potential consequences of such unrealistic assumptions in simulations of tornadoes. Cloud Model 1 (CM1) LES runs are performed using three approaches to model near-surface turbulence: the “semi-slip” boundary condition (which is the most commonly used equilibrium approach), a recently proposed nonequilibrium approach that accounts for some of the effects of turbulence memory, and a nonequilibrium approach based on thin boundary layer equations (TBLE) originally proposed by the engineering community for smooth-wall boundary layer applications. To be adopted for atmospheric applications, the TBLE approach is modified to account for the surface roughness. The implementation of TBLE into CM1 is evaluated using LES results of an idealized, neutral atmospheric boundary layer. LES runs are then performed for an idealized tornado characterized by rapid evolution, strongly curved air parcel trajectories, and substantial horizontal heterogeneities. The semi-slip boundary condition, by design, always yields a surface shear stress opposite the horizontal wind at the lowest LES grid level. The nonequilibrium approaches of modeling near-surface turbulence allow for a range of surface-shear-stress directions and enhance the resolved turbulence and wind gusts. The TBLE approach even occasionally permits kinetic energy backscatter from unresolved to resolved scales.

Significance Statement
The traditional approach of modeling the near-surface turbulence is not suitable for a tornado characterized by rapid evolution, strongly curved air parcel trajectories, and substantial horizontal heterogeneities. To understand the influence of statistically unsteady and horizontally heterogeneous near-surface conditions on tornadoes, this work adopts a fairly sophisticated approach from the engineering community and implements it into a widely used atmospheric model with necessary modifications. Compared to the traditional approach, the newly implemented approach produces more turbulent near-surface winds, more flexible surface-drag directions, and stronger wind gusts. These findings suggest a simulated tornado is very sensitive to the modeling approach of near-surface turbulence.
A Machine Learning Correction Model of the Winter Clear-Sky Temperature Bias over the Arctic Sea Ice in Atmospheric Reanalyses
Authors: Zampieri Lorenzo , Arduini Gabriele , Holland Marika , Keeley Sarah P. E. , Mogensen Kristian , Shupe Matthew D. , Tietsche Steffen 
Published: March 2023

Abstract
Atmospheric reanalyses are widely used to estimate the past atmospheric near-surface state over sea ice. They provide boundary conditions for sea ice and ocean numerical simulations and relevant information for studying polar variability and anthropogenic climate change. Previous research revealed the existence of large near-surface temperature biases (mostly warm) over the Arctic sea ice in the current generation of atmospheric reanalyses, which is linked to a poor representation of the snow over the sea ice and the stably stratified boundary layer in the forecast models used to produce the reanalyses. These errors can compromise the employment of reanalysis products in support of polar research. Here, we train a fully connected neural network that learns from remote sensing infrared temperature observations to correct the existing generation of uncoupled atmospheric reanalyses (ERA5, JRA-55) based on a set of sea ice and atmospheric predictors, which are themselves reanalysis products. The advantages of the proposed correction scheme over previous calibration attempts are the consideration of the synoptic weather and cloud state, compatibility of the predictors with the mechanism responsible for the bias, and a self-emerging seasonality and multidecadal trend consistent with the declining sea ice state in the Arctic. The correction leads on average to a 27% temperature bias reduction for ERA5 and 7% for JRA-55 if compared to independent in situ observations from the MOSAiC campaign (respectively, 32% and 10% under clear-sky conditions). These improvements can be beneficial for forced sea ice and ocean simulations, which rely on reanalyses surface fields as boundary conditions.

Significance Statement
This study illustrates a novel method based on machine learning for reducing the systematic surface temperature errors that characterize multiple atmospheric reanalyses in sea ice–covered regions of the Arctic under clear-sky conditions. The correction applied to the temperature field is consistent with the local weather and the sea ice and snow conditions, meaning that it responds to seasonal changes in sea ice cover as well as to its long-term decline due to global warming. The corrected reanalysis temperature can be employed to support polar research activities, and in particular to better simulate the evolution of the interacting sea ice and ocean system within numerical models.
The Development of Breast Cancer-Related Lymphedema After Mastectomy in a Rural Population
Authors: Clegg Devin J. , Whiteaker Erica N. , Salomon Brett J. , Brooks Ashton J. , Bell John L. , Boukovalas Stefanos , Roberson Patricia N. E. , Lloyd Jillian M. 
Published: March 2023

Breast cancer-related lymphedema (BCRL) is a lifelong condition that can impact the quality of life, affecting approximately 20% of breast cancer patients. Risk factors for the development of BCRL after mastectomy in rural populations have not been studied. Retrospective review of mastectomy patients from 2017 to 2021 was performed at a single institution. Statistical analysis included logistic and linear regression models. 475 patients were included, and 40 (8.4%) patients were diagnosed with BCRL. Increased odds of developing BCRL were significantly associated with tumor-involved lymph nodes, radiation therapy, axillary lymphadenectomy, adjuvant chemotherapy, and endocrine therapy. Postmastectomy reconstruction significantly reduced the odds of developing BCRL. There was no significant association in our population with age, body mass index, diabetes, tobacco use, cancer type, or complications. This study demonstrates that individuals underrepresented in the literature, such as patients in largely rural communities, have some differences in risk factors for developing BCRL when compared to national studies.
CACSV: a computational web-sever that provides classification for cancer somatic genetic variants from different tissues
Authors: AlKurabi Nahla , AlGahtani Ahad , Sobahy Turki M. 
Published: March 2023

Abstract
Background
Understanding the role and function of genetic variants is extremely important when analyzing and interpreting a myriad of human disease processes. For cancer in general, cell-specific genetic variants are ubiquitous and distinct tissues have significantly heterogenic genetic profiles. In clinical practice, only a few genetic variants have identifiable clinical utility. Finding clinically relevant genetic variants constitute a challenging process. In addition, there had been no reference protocol to provide guidance for cancer somatic genetic variants classification and interpretation. In 2017, the first version of a reference protocol was published by the Association for Molecular Pathology, the American Society of Clinical Oncology, and the College of American Pathologists. Previously, we incorporated the reference protocol into a computational method to expedite the process of identification of clinically relevant genetic variants. In this work, we developed a computational web-server to increase the accessibility and availability of clinically relevant genetic variants.

Results
Our work provides the clinical classification for ~ 3 million cancer genetic variants that are now publicly available in a shareable database on GitHub. We have developed a graphical user interface for the database to enhance the accessibility and ease-of-use.

Conclusion
CACSV provides an open-source for about 3 million cancer tissue-specific genetic variants with their assigned clinical annotations.
Application value of Early-Follicular Phase Long-Acting Gonadotropin-Releasing Hormone Agonist Long Protocol in patients with resistant ovary syndrome
Authors: Zhang Fan , Zhang Huixia , Du Hui , Li Xin , Jin Haixia , Li Gang 
Published: March 2023

Abstract
Background
Resistant ovarian syndrome(ROS) is a rare disease. It is difficult to diagnose and treat. Most of the literature reports on assisted pregnancy treatment for ROS patients are individual case reports. In this paper, the ovulation stimulation protocol and assisted pregnancy process of ROS infertile patients in our reproductive center were summarized and analyzed to provide information and support for the clinical treatment of ROS patients.

Methods
From January 2017 to March 2022, assisted reproductive technology treatments and clinical characteristics parameters of six patients with ROS were retrospectively reviewed. Based on controlled ovarian stimulation protocols, these stimulation cycles were separated into four groups: Early-Follicular Phase Long-Acting Gonadotropin-Releasing Hormone Agonist Long Protocol (EFLL) group (n = 6), Progestin Primed Ovarian Stimulation(PPOS) protocol group (n = 5), mild-stimulation protocol group (n = 2), and Natural cycle protocol group (n = 3).

Results
A total of 16 cycles of ovulation stimulation were carried out in 6 patients with ROS. A total of 19 oocytes were retrieved, as well as 13 MII oocytes, 11 two pronuclear(2PN) fertilized embryos, and 8 excellent embryos. The oocytes acquisition rate was 50% and the fertilization rate of 2PN was 57.9%, and the excellent embryo rate was 72.7%. The EFLL protocol obtained 17 oocytes, 12 MII oocytes, 11 2PN fertilized embryos, and 8 excellent embryos; the mild-stimulation protocol obtained 1 oocyte; the Natural cycle protocol obtained 1 oocyte, and oocytes were not matured after in vitro maturation (IVM); the PPOS protocol obtained no oocytes. Compared with three other protocols, The fertilization rate of 2PN (64.7%) and excellent embryo rate (72.7%) in the EFLL protocol were higher than those of other protocols(0%). Two fresh cycle embryo transfers resulted in live births, while two frozen-thawed embryo transfer cycles resulted in one live birth and one clinical pregnancy using the EFLL protocol.

Conclusion
Although the current study is based on a small sample of participants, the findings suggest that the EFLL protocol can be employed for ovarian stimulation and may result in a live birth in ROS patients.
Neoadjuvant chemoradiotherapy plus tislelizumab followed by surgery for esophageal carcinoma (CRISEC study): the protocol of a prospective, single-arm, phase II trial
Authors: Yang Jinsong , Huang Ai , Yang Kunyu , Jiang Ke 
Published: March 2023

Abstract
Background
The failure rate after neoadjuvant chemoradiotherapy followed by surgery is approximately 34.6%–48% for resectable esophageal carcinoma. Pathologic complete response after neoadjuvant chemoradiotherapy is an important factor in predicting lower recurrence and better survival. Whether the sequential addition of immunotherapy to neoadjuvant chemoradiotherapy will be beneficial to improving the pathologic complete response rate is unknown.

Methods
Patients with pathologically confirmed thoracic esophageal squamous cell carcinoma and at clinical T1-2N1-3M0 or T3-4aN0-3M0 (stage II–IVA) according to the eighth edition of American Joint Committee on Cancer staging will be allocated to receive neoadjuvant radiotherapy (41.4 Gy with 23 fractions to planning target volume) with concurrent chemotherapy (albumin-bound paclitaxel, 100 mg/m2, once weekly for five weeks; carboplatin, area under the curve of 2 mg/mL/min, once weekly for five weeks) plus tislelizumab monotherapy sequentially (200 mg every three weeks for three cycles, beginning from the first to the 14th day after the end of radiotherapy). Then, subtotal esophagectomy with two-field lymphadenectomy, including the whole mediastinum and abdomen, will be performed. The primary endpoint for this study is the pathologic complete response rate after neoadjuvant chemoradiotherapy plus tislelizumab.

Discussion
The optimal timing of the combination of immunotherapy and neoadjuvant chemoradiotherapy in esophageal carcinoma is not determined. The results of this phase II trial will be helpful to clarify the safety and efficacy of the sequential addition of tislelizumab after neoadjuvant chemoradiotherapy for locally advanced resectable esophageal carcinoma.

Trial registration
This study was approved on January 26, 2021 and retrospectively registered with ClinicalTrials.gov (NCT04776590) on March 1, 2021.
Viral load suppression in HIV-infected adolescents in cameroon: towards achieving the UNAIDS 95% viral suppression target
Authors: Djiyou Armando B. D. , Penda Calixte Ida , Madec Yoann , Ngondi Grace Dalle , Moukoko Astrid , Varloteaux Marie , de Monteynard Laure-Amélie , Moins Cecile , Moukoko Carole Else Eboumbou , Aghokeng Avelin F. 
Published: March 2023

Abstract
Background
Achieving the UNAIDS 95% sustained viral suppression (VS) rate requires considerable global efforts, particularly among adolescents living with HIV (ALHIV) who are often associated with high rates of virological failure (VF). In this study, we prospectively assessed the rate of VS, and the factors associated with VF in a cohort of adolescents followed up according to the WHO guidelines in Cameroon.

Methods
A cross-sectional study was carried out in 2021 among adolescents (aged 10–19 years) receiving ART in the national program in Cameroon. Socio-demographic and clinical data were collected using patients’ medical files and a brief interview with the participant and/or his guardian. Thereafter, a first viral load test (VL1) was performed using the ABBOTT Platform. For adolescents with VL1 > 1000 copies/ml, adherence-enhancing interventions were routinely performed each month for 3 consecutive months, after which a second viral load (VL2) was measured. Adolescents with VL2 > 1000 copies/ml were considered in VF.

Results
Overall, 280 adolescents were enrolled, of whom 89.3% (250/280) acquired HIV infection via mother-to-child transmission. The median age was 16.0 (IQR: 13.0–18.0) years and the median duration on ART was 9.8 (IQR: 5.1–12.8) years. Females and males were almost equally represented, as 52.1% (146/280) were female, while 47.9% (134/280) were males (p = 0.47). The VS rate was 88.2% (CI: 83.8-91.7%) overall; 89.0% (CI: 82.0-93.1%) and 88.7% (CI: 81.2-93.0%) in females and males, respectively. Being on second or third-line ART, self-declared suboptimal adherence, and a history of past VF were independently associated with VF.

Conclusion
The high rate of VS we report in this study is welcome in the era of the 95/95/95 UNAIDS goals, and indicates that improving treatment outcomes in this specific and fragile population that represent adolescents in Sub-Saharan Africa is achievable.

Trial registration
20/10/2020 NCT04593979 (https://clinicaltrials.gov/ct2/show/NCT04593979).
Adolescent suicidal behaviour in Namibia: a cross-sectional study of prevalence and correlates among 3,152 school learners aged 12–17 years
Authors: Quarshie Emmanuel Nii-Boye , Dey Nutifafa Eugene Yaw , Oppong Asante Kwaku 
Published: March 2023

Abstract
Background
While adolescent suicidal behaviour (ideation, planning, and attempt) remains a global public health concern, available county-specific evidence on the phenomenon from African countries is relatively less than enough. The present study was conducted to estimate the 12-month prevalence and describe some of the associated factors of suicide behaviour among school-going adolescents aged 12–17 years old in Namibia.

Methods
Participants (n = 4531) answered a self-administered anonymous questionnaire developed and validated for the nationally representative Namibia World Health Organization Global School-based Student Health Survey conducted in 2013. We applied univariate, bivariable, and multivariable statistical approaches to the data.

Results
Of the 3,152 analytical sample, 20.2% (95% confidence interval [CI]: 18.3–22.2%) reported suicidal ideation, 25.2% (95% CI: 22.3–28.4%) engaged in suicide planning, and 24.5% (95% CI: 20.9–28.6%) attempted suicide during the previous 12 months. Of those who attempted suicide, 14.6% (95% CI: 12.5–16.9%) reported one-time suicide attempt, and 9.9% (95% CI: 8.1–12.1%) attempted suicide at least twice in the previous 12 months. The final adjusted multivariable models showed physical attack victimisation, bullying victimisation, loneliness, and parental intrusion of privacy as key factors associated with increased likelihood of suicidal ideation, planning, one-time suicide attempt, and repeated attempted suicide. Cannabis use showed the strongest association with increased relative risk of repeated attempted suicide.

Conclusion
The evidence highlights the importance of paying more attention to addressing the mental health needs (including those related to psychological and social wellness) of school-going adolescents in Namibia. While the current study suggests that further research is warranted to explicate the pathways to adolescent suicide in Namibia, identifying and understanding the correlates (at the individual-level, family-level, interpersonal-level, school context and the broader community context) of adolescent suicidal ideations and non-fatal suicidal behaviours are useful for intervention and prevention programmes.
Evolution of smoking rates among immigrants in France in the context of comprehensive tobacco control measures, and a decrease in the overall prevalence
Authors: Mahdjoub Sarah , Héron Mégane , Gomajee Ramchandar , Ducarroz Simon , Melchior Maria , El-Khoury Lesueur Fabienne 
Published: March 2023

Abstract
Background
The evolution of smoking rates according to migrant status has not been examined in France, despite a recent reduction in overall smoking rates.

Methods
DePICT is a two waves (2016: n = 4356; 2017: n = 4114) nationwide telephone survey, representative of the French adult population. We compared smoking-related behaviors before and after implementation of tobacco-control measures (2017), according to the geographical region of birth.

Results
Compared to 2016, individuals originating from Africa or the Middle East had a slightly higher smoking prevalence in 2017 (34.7% vs 31.3%), despite a higher intention to quit or attempt in the preceding year (adjusted OR(ORa) = 2.72[1.90; 3.90]) compared to non-immigrants. They were also less likely to experience an unsuccessful quit attempt (ORa = 1.76[1.18; 2.62]).

Conclusion
Tobacco-control measures could have widened smoking inequalities related to migrant status. The evolution of smoking-related behaviors among immigrants should be examined when studying the long-term effects of such policies.