bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of continuance intention to use food delivery apps: findings from PLS and fsQCA
Authors: Foroughi Behzad , Yadegaridehkordi Elaheh , Iranmanesh Mohammad , Sukcharoen Teerachart , Ghobakhlo Morteza , Nilashi Mehrbakhsh 
Published: June 2023

Purpose
Customers increasingly use food delivery applications (FDAs) to place orders. Despite the popularity of FDAs, limited research has investigated the drivers of the continuance intention to use FDAs. This study aims to uncover the drivers of the continuance intention to use FDAs by integrating the “technology continuance theory” (TCT) with perceived task-technology fit, perceived value and perceived food safety.

Design/methodology/approach
Data were collected from 398 individuals in Thailand and evaluated using “partial least squares” (PLS) and “fuzzy-set qualitative comparative analysis” (fsQCA).

Findings
The PLS results supported the significance of all direct relationships, except the effects of perceived ease of use on attitude and perceived usefulness on continuance intention. Accordingly, perceived food safety positively moderated the impact of perceived ease of use on attitudes. The fsQCA uncovered seven solutions with various combinations of factors that predicted high continuance intention.

Practical implications
This study enables food delivery apps to develop effective strategies for retaining users and sustaining financial performance.

Originality/value
This research contributes to the literature by investigating the factors underlying the continuous use of FDAs with a new PLS-fsQCA technique and applying TCT in a new technological context, FDAs and enriching it by adding three variables: perceived task-technology fit, perceived value and perceived food safety.
Governance, regulatory quality and financial institutions: emerging economies perspective
Authors: Abaidoo Rexford , Agyapong Elvis Kwame 
Published: June 2023

PurposeThe study evaluates the effects of governance and other regulatory structures on the development of financial institutions in the subregion of sub-Saharan Africa (SSA).Design/methodology/approachData for the analyses were compiled from relevant sources from 1996 to 2019 from a sample of 36 countries in the subregion. Empirical analyses were carried out using the Prais-Winsten panel corrected standard errors panel estimation technique augmented by pooled ordinary least squares with Driscoll and Kraay (1998) standard errors model.FindingsFindings from the study suggest that governance and institutional quality index, as well as individual governance and regulatory variables, have positive effect on the development of financial institutions among economies in SSA. Further empirical estimates show that output growth volatility has negative moderating impact on the relationship between effective governance, control of corruption, rule of law, regulatory quality, voice and accountability, and development of financial institutions. Additionally, the results show that during periods of heightened macroeconomic risk, financial institutions could benefit from improved governance and effective regulatory structures.Originality/valueCompared to related studies that have reviewed the discourse on financial institutions, this study rather focuses on how governance structures and institutions influence development of financial institutions instead of the impact of financial institution on the broader economy. The authors further augment this interaction by examining how the relationship in question may be moderated by macroeconomic shocks.
Boosting customized and personalized interactive livestreaming experiences. Is Amazon Explore competing or complementing the hospitality industry?
Authors: Ramadan Zahy , Farah Maya , Al Rahbany Norma 
Published: June 2023

Purpose
Following the changes in consumer behavior in the hospitality industry due to the Covid-19 pandemic, Amazon launched “Explore”, an interactive livestreaming customized service that connects users with hosts worldwide, allowing them to discover a vast array of experiences from the comfort of their homes. This study aims to assess the effects of Explore on the hospitality and tourism industries.

Design/methodology/approach
An exploratory qualitative approach was adopted. Data was collected from 18 expert interviews and 292 online reviews on Explore.

Findings
The findings indicate that the pandemic has altered consumer behavior when it comes to experience-related venues. Within that shift, Explore was shown to have reinvented the travel industry. The major three themes extracted revolved around the following: replica of real-life touristic experiences (having the experience as if consumers were physically present), experience-bound versus output-oriented customers (those who want to explore the real experience by being physically present versus those who seek to discover a certain culture or acquire a new skill even virtually) and post-virtual experience (effects on the hospitality industry).

Originality/value
The study puts forth the coopetition that could emanate from the inter-relationship between the Amazon Explore platform and the hospitality industry if the two were to cooperate even beyond the context of global pandemics. Indeed, Explore has gained awareness and trial and could be a sustainable ongoing business, especially among those with financial and other types of limitations that could hinder their traveling propensity.
Bioactive compounds and antioxidant activity in garambullo fruit (Myrtillocactus geometrizans) at different ripening stages
Authors: Yahia Elhadi M. , Victoria‐Campos Claudia Inés , Gonzalez‐Nava Catalina 
Published: June 2023

AbstractGarambullo (Myrtillocactus geometrizans) is endemic in México, and although popularly consumed locally, its nutritional characteristics and value have not been studied in details. The objective of this work was to investigate the bioactive compounds and antioxidant activity in garambullo fruit from different sites at three ripening stages. Fruit from the three ripening stages (red, purple, and dark purple) were investigated for their physicochemical characteristics, hydrophilic (phenolic compounds, betalains, and ascorbic acid), and lipophilic (carotenoids, tocopherols, and fatty acids) bioactive compounds, using spectrophotometry, gas chromatography (GC‐FID), and high‐pressure liquid chromatography coupled to mass spectrometry (HPLC/DAD‐ESI‐MS). The antioxidant capacity was measured with the 2,2′‐diphenyl‐1‐picrylhydrazyl and the ferric‐ion‐reducing antioxidant power assays. The color components of the fruit, chroma and a* values increased, whereas lightness (L*) and b* significantly decreased during ripening. Five betacyanins and four betaxanthins were tentatively identified with HPLC/DAD‐ESI‐MS, and betacyanins were more abundant than betaxanthins. Betalains content and antioxidant capacity of hydrophilic extracts significantly increased during ripening. Ten phenolic compounds were identified, with ferulic acid being the most abundant. Tocopherols were low (0.023–0.033 mg/100 g fw). Five fatty acids were abundant, and linoleic acid was the most important. Phenolic compounds, ascorbic acid, total carotenoids, and fatty acids decreased during fruit ripening. Garambullo fruit is rich in phytochemical compounds of importance for human nutrition and health.Practical ApplicationThe physicochemical and bioactive compounds characterization in garambullo fruit is important to establish maturation and harvesting indices, postharvest strategies to preserve fruit quality and prolong postharvest life, promote the consumption and utilization of the fruit, and the designing of proper functional foods. In addition, the knowledge on the bioactive components might be useful to include this fruit in personalized nutritional approaches for patients with risks of certain chronic diseases. The methodology used in this study could be useful for the study of other fruits, especially those from the Cactaceae family.
A generalizable normalization for assessing plant functional diversity metrics across scales from remote sensing
Authors: Pacheco‐Labrador Javier , de Bello Francesco , Migliavacca Mirco , Ma Xuanlong , Carvalhais Nuno , Wirth Christian 
Published: June 2023

Abstract

Remote sensing (RS) increasingly seeks to produce global‐coverage maps of plant functional diversity (PFD) across scales. PFD can be quantified with metrics assessing field or RS data dissimilarity. However, their comparison suffers from the lack of normalization approaches that (1) correct for differences in the number and correlation of traits and spectral variables and (2) do not require comparing all the available samples to estimate the maximum trait's dissimilarity (unfeasible in RS).

We propose a generalizable normalization (GN) based on the maximum potential dissimilarity for the traits and spectral data considered and compare it to more traditional approaches (e.g. the maximum dissimilarity within datasets). To do so, we simulated plant communities with radiative transfer models and compared RS‐based diversity measurements across spatial scales (α‐ and β‐diversity components). Specifically, we assessed the capability of different normalization approaches (GN, local, none) to provide PFD estimates comparable between (1) RS and plant traits and (2) estimates from different RS missions.

Unlike the other approaches, GN provides diversity component estimates that are directly comparable between field data and RS missions with different spectral configurations by removing the effect of differences in the number of traits or bands and the maximum dissimilarity across datasets.

Therefore, GN enables the separated analysis of RS images from different sensors to produce comparable global‐coverage cartography. We suggest GN is necessary to validate RS approaches and develop interpretable maps of PFD using different RS missions.
Real‐world effectiveness of vedolizumab compared toanti‐TNFagents in biologic‐naïve patients with ulcerative colitis: A two‐year propensity‐score‐adjusted analysis from the prospective, observationalVEDOIBD‐study
Authors: Bokemeyer Bernd , Plachta‐Danielzik Sandra , di Giuseppe Romina , Efken Philipp , Mohl Wolfgang , Krause Thomas , Hoffstadt Martin , Ehehalt Robert , Trentmann Leo , Schweitzer Axel , Jessen Petra , Hartmann Petra , Schreiber Stefan 
Published: June 2023

SummaryBackgroundThis observational real‐world evidence (RWE) study is based on prospectively collected data from the VEDOIBDregistry study.AimTo compare the effectiveness of vedolizumab and anti‐TNF agents in biologic‐naïve patients with ulcerative colitis (UC) at the end of induction and during maintenance treatment.MethodsBetween 2017 and 2020, we enrolled 512 patients with UC starting therapy with vedolizumab or an anti‐TNF agent in 45 IBD centres across Germany. We excluded biologic‐experienced patients and those with missing partial Mayo (pMayo) outcomes; this resulted in a final sample of 314 (182 on vedolizumab and 132 on an anti‐TNF agent). The primary outcome was clinical remission measured using pMayo score; any switch to a different biologic agent was considered an outcome failure (modified ITT analysis). We used propensity score adjustment with inverse probability of treatment weighting to correct for confounding.ResultsDuring induction therapy, clinical remission was relatively low and similar in vedolizumab‐ and anti‐TNF‐treated patients (23% vs. 30.4%,p = 0.204). However, clinical remission rates after two years were significantly higher for vedolizumab‐treated patients than those treated with an anti‐TNF agent (43.2% vs. 25.8%,p < 0.011). Among patients treated with vedolzumab, 29% switched to other biologics, versus 54% who had received an anti‐TNF agent.ConclusionAfter two years of treatment, vedolizumab resulted in higher remission rates than anti‐TNF agents.
Comparative pharmacokinetics of nalbuphine nasal spray and solution for injection in healthy volunteers
Authors: Tymko Volodymyr G. , Tsapko Grigorii V. , Kovalova Kateryna V. , Mashchenko Serhii V. , Oliinykov Dmytro S. , Kuznetsov Igor E. 
Published: June 2023

AbstractAimsNalbuphine is a synthetic opioid with comparable analgesic activity to morphine but with a better safety profile. Nalbuphine is only available in injectable form due to low oral bioavailability. Nasal nalbuphine spray provides advantages in drug safety, avoids hepatic first‐pass metabolism, is non‐invasive and is convenient for patient‐controlled analgesia by self‐administration. This study aimed to evaluate the safety and pharmacokinetics (PK) of the newly developed nalbuphine nasal spray in comparison with a solution for injections.MethodsTwenty‐four healthy Caucasian volunteers were enrolled in this randomized, open‐label, cross‐over study. Subjects were administered one of the drugs: nasal spray 7.0 mg/dose, nalbuphine hydrochloride solution for injection 10 mg/dose intravenously (IV) or intramuscularly (IM). High‐performance liquid chromatography–tandem mass spectrometry was used to determine nalbuphine concentrations.ResultsA comparison of PK profiles for IV, IM and intranasal (IN) routes of nalbuphine administration revealed a close similarity of absorption phases for nasal spray and IM injection. Differences between the mean Tmax and dose‐adjusted Cmax values for nasal spray and IM injection were statistically insignificant. The median values of the elimination rate constants and the terminal elimination half‐life following IV, IM and IN nalbuphine administration were similar. The mean absolute bioavailability of the nasal spray equalled 65.04%.ConclusionsThe similarity of PK parameters of IM‐injected nalbuphine solution and the nasal spray allows us to assume the latter is a feasible alternative to intramuscular nalbuphine injections appropriate for self‐administration and field environments for managing moderate and severe pain of various aetiologies.
Using cognitive and behavioural strategies to support a man with mild–moderate learning disabilities navigate the dual process model of grief: A clinical case study
Authors: Calabria Luis , Cheswick Claire 
Published: June 2023

AbstractBackgroundPeople with learning disabilities experience bereavement in the same emotionally overwhelming way as the general population. The Dual‐Process Model of grief is characterised by the oscillation between Loss‐Orientation and Restoration‐Orientation. These processes involve experiencing and accepting the emotional pain of grief (Loss‐Orientation) and adapting to a new world without the deceased person (Restoration‐Orientation).MethodsA single case study sought to explore how Cognitive Behavioural Therapy (CBT) and Compassion Focused Therapy (CFT) principles can be used to support people with a learning disability to navigate the grieving process, as understood by the Dual‐Process Model.FindingsThis case study describes CBT formulation and assessment, and implementation of CBT and CFT strategies in a man with Williams syndrome, demonstrating improvements in mood, and a greater ability to turn towards suffering and experience both Loss‐ and Restoration‐Oriented processing.ConclusionCBT and CFT may be useful and appropriate modalities for clinicians to consider when supporting people with a learning disability to navigate loss, as understood through the Dual Process Model.
Mitochondria: At the crossroads between mechanobiology and cell metabolism
Authors: Su Émilie , Villard Catherine , Manneville Jean‐Baptiste 
Published: June 2023

AbstractMetabolism and mechanics are two key facets of structural and functional processes in cells, such as growth, proliferation, homeostasis and regeneration. Their reciprocal regulation has been increasingly acknowledged in recent years: external physical and mechanical cues entail metabolic changes, which in return regulate cell mechanosensing and mechanotransduction. Since mitochondria are pivotal regulators of metabolism, we review here the reciprocal links between mitochondrial morphodynamics, mechanics and metabolism. Mitochondria are highly dynamic organelles which sense and integrate mechanical, physical and metabolic cues to adapt their morphology, the organization of their network and their metabolic functions. While some of the links between mitochondrial morphodynamics, mechanics and metabolism are already well established, others are still poorly documented and open new fields of research. First, cell metabolism is known to correlate with mitochondrial morphodynamics. For instance, mitochondrial fission, fusion and cristae remodeling allow the cell to fine‐tune its energy production through the contribution of mitochondrial oxidative phosphorylation and cytosolic glycolysis. Second, mechanical cues and alterations in mitochondrial mechanical properties reshape and reorganize the mitochondrial network. Mitochondrial membrane tension emerges as a decisive physical property which regulates mitochondrial morphodynamics. However, the converse link hypothesizing a contribution of morphodynamics to mitochondria mechanics and/or mechanosensitivity has not yet been demonstrated. Third, we highlight that mitochondrial mechanics and metabolism are reciprocally regulated, although little is known about the mechanical adaptation of mitochondria in response to metabolic cues. Deciphering the links between mitochondrial morphodynamics, mechanics and metabolism still presents significant technical and conceptual challenges but is crucial both for a better understanding of mechanobiology and for potential novel therapeutic approaches in diseases such as cancer.
Overcoming the H4K20me3 epigenetic barrier improves somatic cell nuclear transfer reprogramming efficiency in mice
Authors: Liu Zhihui , Wang Weiguo , Xia Yuhan , Gao Yuan , Wang Zhisong , Li Mingyang , Presicce Giorgio Antonio , An Liyou , Du Fuliang 
Published: June 2023

AbstractEpigenetic reprogramming during fertilization and somatic cell nuclear transfer (NT) is required for cell plasticity and competent development. Here, we characterize the epigenetic modification pattern of H4K20me3, a repressive histone signature in heterochromatin, during fertilization and NT reprogramming. Importantly, the dynamic H4K20me3 signature identified during preimplantation development in fertilized embryos differed from NT and parthenogenetic activation (PA) embryos. In fertilized embryos, only maternal pronuclei carried the canonical H4K20me3 peripheral nucleolar ring‐like signature. H4K20me3 disappeared at the 2‐cell stage and reappeared in fertilized embryos at the 8‐cell stage and in NT and PA embryos at the 4‐cell stage. H4K20me3 intensity in 4‐cell, 8‐cell, and morula stages of fertilized embryos was significantly lower than in NT and PA embryos, suggesting aberrant regulation of H4K20me3 in PA and NT embryos. Indeed, RNA expression of the H4K20 methyltransferase Suv4‐20h2 in 4‐cell fertilized embryos was significantly lower than NT embryos. Knockdown of Suv4‐20h2 in NT embryos rescued the H4K20me3 pattern similar to fertilized embryos. Compared to control NT embryos, knockdown of Suv4‐20h2 in NT embryos improved blastocyst development ratios (11.1% vs. 30.5%) and full‐term cloning efficiencies (0.8% vs. 5.9%). Upregulation of reprogramming factors, including Kdm4b, Kdm4d, Kdm6a, and Kdm6b, as well as ZGA‐related factors, including Dux, Zscan4, and Hmgpi, was observed with Suv4‐20h2 knockdown in NT embryos. Collectively, these are the first findings to demonstrate that H4K20me3 is an epigenetic barrier of NT reprogramming and begin to unravel the epigenetic mechanisms of H4K20 trimethylation in cell plasticity during natural reproduction and NT reprogramming in mice.
Prehospital seizures: Short‐term outcomes and risk stratification based in point‐of‐care testing
Authors: Donoso‐Calero María I. , Martín Conty José L. , López‐Izquierdo Raúl , Sanz‐García Ancor , Dileone Michele , Polonio‐López Begoña , Mordillo‐Mateos Laura , Delgado Benito Juan F. , del Pozo Vegas Carlos , Mohedano‐Moriano Alicia , Martín‐Rodríguez Francisco 
Published: June 2023

AbstractBackgroundInformation for treatment or hospital derivation of prehospital seizures is limited, impairing patient condition and hindering patients risk assessment by the emergency medical services (EMS). This study aimed to determine the associated factors to clinical impairment, and secondarily, to determine risk factors associated to cumulative in‐hospital mortality at 2, 7 and 30 days, in patients presenting prehospital seizures.MethodsProspective, multicentre, EMS‐delivery study involving adult subjects with prehospital seizures, including five advanced life support units, 27 basic life support units and four emergency departments in Spain. All bedside variables: including demographic, standard vital signs, prehospital laboratory tests and presence of intoxication or traumatic brain injury (TBI), were analysed to construct a risk model using binary logistic regression and internal validation methods.ResultsA total of 517 patients were considered. Clinical impairment was present in 14.9%, and cumulative in‐hospital mortality at 2, 7 and 30‐days was 3.4%, 4.6% and 7.7%, respectively. The model for the clinical impairment indicated that respiratory rate, partial pressure of carbon dioxide, blood urea nitrogen, associated TBI or stroke were risk factors; higher Glasgow Coma Scale (GCS) scores mean a lower risk of impairment. Age, potassium, glucose, prehospital use of mechanical ventilation and concomitant stroke were risk factors associated to mortality; and oxygen saturation, a high score in GCS and haemoglobin were protective factors.ConclusionOur study shows that prehospital variables could reflect the clinical impairment and mortality of patients suffering from seizures. The incorporation of such variables in the prehospital decision‐making process could improve patient outcomes.
Computer aided design/computer aided manufacturing (CAD/CAM) technology in the undergraduate dental programs in the MENA region
Authors: Islam Md Sofiqul , Al‐Fakhri Ali , Rahman Mohammed Mustahsen 
Published: June 2023

AbstractIntroductionThe aim of this study was to understand the trends of teaching Computer Aided Design/Computer Aided Manufacturing (CAD/CAM) in the undergraduate dental curriculum in the MENA region by conducting an online survey among the undergraduate dental colleges in this region.Materials and MethodsAn online survey was conducted using Google Forms consisting of 20 questions that could be answered by “yes” or “no” responses, multiple‐choice answers or in a descriptive, “open” format. A total of 55 participants from the MENA region representing their dental college were requested to participate in this study.ResultsThe response rate of the survey was 85.5% following the twofold follow‐up reminders method. Although the vast majority of professors demonstrated vital knowledge in the practical use of CAD/CAM, the majority of them did not provide theoretical and practical training on CAD/CAM in their institutions. Among the schools with established levels of teaching CAD/CAM, nearly 50% of them provide both pre‐clinical and clinical training on CAD/CAM. Despite the availability of extra‐curricular training courses on CAD/CAM outside the university setting, there is a lack of advocating for students to enrol in those courses by the institutions. More than 80% of the participants agreed that CAD/CAM has a strong future in chair‐side dental clinics and CAD/CAM needs to be incorporated within undergraduate studies.ConclusionBased on the results of the current study, it is understandable that an intervention is required by the dental education providers to cope with the growing demand for CAD/CAM technology for the current and future dental practitioners of the MENA region.