bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis
Authors: Raleigh David , Mirchia Kanish , Choudhury Abrar , Joseph Tara , Birrueta Janeth , Phillips Joanna , Bhaduri Aparna , Crouch Elizabeth , Perry Arie 
Published: July 2023

Abstract
Meningeal solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that are associated with hematogenous metastasis, and the cell states and spatial transcriptomic architecture of SFTs are unknown. Here we use single-cell and spatial RNA sequencing to show SFTs are comprised of regionally distinct gene expression programs that resemble cerebral vascular development and homeostasis. Our results shed light on pathways underlying SFT biology in comparison to other central nervous system tumors and provide a framework for integrating single-cell and spatial transcriptomic data from human cancers and normal tissues.
Understanding Suboptimal Insulin Use in Type 1 and 2 Diabetes: A Cross-sectional Survey of Healthcare Providers who Treat People With Diabetes
Authors: Newson Rachel S. , Spaepen Erik , Liao Birong , Bower Julie , Bhattacharya Indranil , Artime Esther , Polonsky William 
Published: July 2023

Abstract

Background: The purpose of this study was to understand the healthcare provider (HCP) perspective on the extent of suboptimal insulin dosing in people with diabetes (PwD), as well as specific challenges and solutions to insulin management.
Methods: An online survey of general practitioners and specialists (N=640) who treat people with diabetes in Germany, Spain, the United Kingdom, and the United States was conducted. Responses regarding HCP background and their patients, HCP perceptions of suboptimal insulin use, and challenges associated with optimal insulin use were collected. Categorical summary statistics were presented.
Results:Overall, for type 1 diabetes (T1D) and type 2 diabetes (T2D), most physicians indicated <30% of PwD missed or skipped a bolus insulin dose in the last 30 days (T1D: 83.0%; T2D: 74.1%). The top 3 reasons (other than skipping a meal) HCPs believed caused the PwD to miss or skip insulin doses included “they forgot,” (bolus: 75.0%, basal: 67.5%) “they were too busy/distracted,” (bolus: 58.8%, basal: 48.3%), and “they were out of their normal routine” (bolus: 57.8%, basal: 48.6%). HCPs reported similar reasons that they believed caused PwD to mistime insulin doses. Digital technology and improved HCP-PwD communication were potential solutions identified by HCPs to optimize insulin dosing in PwD.
Conclusions: The results of this study reveal HCPs believe the extent of suboptimal insulin dosing is less widespread than studies in PwD of self-reported insulin dosing. This discrepancy could lead to difficulties in HCPs giving PwD the best advice on optimal insulin management. Approaches such as improving the objectivity of dose measurements for both PwD and HCPs may improve associated communications and help reduce suboptimal insulin dosing, thus enhancing treatment outcomes.
Ethical considerations for Biobanking and Use of Genomics Data in Africa: A narrative review
Authors: Amoakoh-Coleman Mary , Vieira Dorice , Abugri James 
Published: July 2023

Abstract
Background
Biobanking and genomic research requires collection and storage of human tissue from study participants. From participants’ perspectives within the African context, this can be associated with fears and misgivings due to a myriad of factors including myths and mistrust of researchers. From the researchers angle ethical dilemmas may arise especially with consenting and sample reuse during storage. The aim of this paper was to explore these ethical considerations in the establishment and conduct of biobanking and biogenomic studies in Africa.
Methods
We conducted a narrative synthesis following a comprehensive search of nine (9) databases and grey literature. Ethical issues studied related to community knowledge and understanding of biobanking and genomic research, regulation, and governance of same by research ethics committees, enrolment of participants, types of informed consents, data collection, storage, usage and sharing as well as material transfer, returning results and benefit sharing.
Results
Of 2,663 title and abstracts screened, 94 full texts were retrieved and reviewed for eligibility. We included 12 studies (7 qualitative; 4 quantitative and one mixed methods). More education of study participants is needed, as well as appropriate community engagement processes that allow community confidence in enrolment into such studies. Competence of review and ethics committees (RECs) should be enhanced to adequately review and govern biobanking and genomic research in Africa. Biospecimen collection and storage is given in trust and participants expect confidentially of data and results generated. Most participants are comfortable with broad consent due to trust in researchers, though a few would like to be contacted for reconsenting in future studies, and this would depend on whether the new research is for good cause. Sharing data with external partners is welcome in some contexts but some research participants did not trust foreign researchers.
Conclusion
With these varying ethical considerations, we recommend that stakeholders, including research ethics committees, work together to adapt and use clearly defined ethical frameworks, guidelines, and policy documents to harmonize the establishment and running of biobanking and genomic research in Africa.
Case Report: Application of HoloLens for Intra-Operative Assessment of a Retrosternal Thyroid Goitre
Authors: Leong Eugene Kwong Fei , Cheng Aldred , Lee James Wai Kit , Gao Yujia , Ngiam Kee Yuan 
Published: July 2023

Abstract
Thyroidectomy is a common surgical procedure performed to treat a myriad of thyroid pathologies. 2-19% of thyroidectomies involve a retrosternal goitre, which is an extension of thyroid tissue into the thoracic cavity. Resection of retrosternal goitres are more challenging that standard thyroidectomies and typically have higher complication rate of recurrent laryngeal nerve injury, hypoparathyroidism and post op bleeding. Goitres can be removed either via a transcervical approach, transthoracic approach or a combination of both. A transcervical approach is generally favoured. Direct visualisation of the lower poles of the goitre is challenging in such scenarios, making it difficult to confirm full removal of the goitre. Retrosternal goitres are usually evaluated and characterised with cross-sectional imaging such as a computed tomography (CT) scan, in order to estimate the size and location of the goitre. We demonstrate a mixed reality technique of visualising retrosternal goitres, involving projecting three-dimensional (3D) reconstruction of the CT scan onto the patient to directly visualise the size and location of the goitre. This guides surgeons in the removal of retrosternal goitres, with the aim to reduce complications and facilitate complete excision of the goitre. We believe that HoloLens2 is a novel new adjunct which will aid surgeons in future surgeries involving a retrosternal goitre.
Study of Extraction method Project of forestry slope position information based on hyperspectral remote sensing technology With Sustainability Requirements
Authors: SUN Wei , FENG Zhongke , SU Yaocheng , Kadaei Samireh 
Published: July 2023

Abstract
In order to solve the project problems of low accuracy of extraction of forestry information, small extraction area and incomplete extraction results in traditional methods, a forestry slope position information extraction method based on hyperspectral remote sensing technology was proposed here to select the study area and analyse its geographic profile. The data used in the study was Digital Elevation Model (DEM) raster data with a resolution of 25m, and the gradient information of the slope position was vaguely expressed. We calculated the fuzzy membership degree of the position to be inferred relative to each typical position in the type of slope position, and then synthesized the fuzzy membership degree of the position to be inferred relative to each typical position to obtain the gradient information of the slope position. Using hyperspectral remote sensing technology to identify forestry slope position, we matched the identified forestry slope position information, and finally extracted forestry slope position information based on statistical analysis technology. The experimental results showed that the forestry information extraction accuracy of the method in this paper is higher, the extraction area is larger and the extraction results are more comprehensive, indicating that our proposed method effectively improves the effect of forestry information extraction.
Transanal total mesorectal excision (TaTME) in rectal cancer treatment within an expert center
Authors: Piątkowski Jacek , Jagielski Mateusz , Szeliga Jacek , Nowak Mariusz , Jackowski Marek 
Published: July 2023

Abstract
The objective of this study was to evaluate treatment outcomes in patients who underwent the TaTME procedure for cancer of the middle and low rectum in an expert center. Prospective analysis of the outcomes of all consecutive patients treated using the TaTME technique for cancer of the middle and distal rectum at the our medical center between March 1, 2015, and March 31, 2022. A total of 128 patients (34 women, 94 men; mean age 66.01 [38–85] years) with cancer of the middle and distal rectum qualified for TaTME. TaTME procedures were performed in 127/128 (99.22%) patients. Complications of surgery were observed in 22/127 (17.32%) patients. Negative proximal and distal margins were confirmed in all 127 patients. Complete (R0) resection of the mesorectum was confirmed in 125/127 (98.43%) and nearly complete (R1) resection was confirmed in 2/127 (1.57%) patients. The average follow-up period was 795 days (296–1522) days. Local recurrence was detected during the follow-up period in 2/127 (1.57%) patients. This study showed that the TaTME procedure is an effective and safe method for the minimally invasive treatment of middle and low rectal cancers, particularly within an expert center setting.
Effect of carburising agent on the preparation of molybdenum carbides by plasma and their catalytic HDO of o-cresol
Authors: Yu Zihan , Yu Zhiquan , Wang Yao , Wang Anjie 
Published: July 2023

Abstract
In this paper, molybdenum carbides have been prepared by DBD plasma using mixtures of H2 and CH4. C2H4 or C3H8 with different hydrocarbon/H2 successfully, and characterized by XRD, XPS, Raman, CO2-TPO and H2-TPD. The results of XRD show that the different carburising agents and C/H2 have little influence on β-Mo2C particles size at input power 40 W. Carburising with a mixture of H2 and C2H4 gives rise to ƞ-MoO1 − x and then deeply carbonized to β-Mo2C, while when using CH4 or C3H8 as the carbon source, MoO2 is directly carbonized to β-Mo2C. Besides, the kind of carburising agents has no effect on the input power of synthetic β-Mo2C (40 W). XPS, Raman and CO2-TPO characterization revealed the effect of carburising agents and hydrocarbon /H2 on the amount of carbon deposition during the surface of the β-Mo2C. Under the same C/H2, the surface of Mo2C-E has the lowest carbon deposition, while the carbon deposition on the surface of Mo2C-M is highest, and with the increasing of hydrocarbon /H2 of the same carburising agent, the carbon deposition on the surface increases. Mo2C-M, Mo2C-E and Mo2C-P were evaluated in the hydrodeoxygenation of o-cresol, using a stainless-steel tubular reactor. The results showed that the Mo2C-E (C2H4/H2 = 1/8) shows the better catalytic performance and the toluene yield is over 80%, which can be attributed to the more active sites and the lower carbon deposition, and this result is consistent with the result of H2-TPD.
Synthesis and characterization of LiNi0,5Mn0,4Co0,1O2 as a cathode material for lithium-ion batteries using coprecipitation method
Authors: Purwamargapratala Yustinus , Zulfia Anne , Kartini Evvy , Hardian Michael 
Published: July 2023

Abstract
Previous research on NMC811 showed that the higher the Ni content over NMC622, the faster the thermal stability decreased. Therefore, it is necessary to have a type of NMC cathode material that is thermally stable and has better electrochemical performance. In this research, the synthesis of cathode material LiNi0.5Mn0.4Co0.1O2 (NMC541) was carried out using the coprecipitation method to determine the character of the material with variations in calcination temperature of 700, 800 and 850oC. XRD and RAMAN analysis of samples and comparison with references shows that NMC541 material is formed. Observation of surface morphology using SEM on calcified samples at 800oC for 8 hours showed a homogeneous distribution of particles and relatively uniform sizes, as well as the highest conductivity value of 5.099x10− 3 S.cm− 1. Measurements using TEM showed that average grain size of NMC particles was 129.834 nm.
Hutchinson’s intervals and entire functions from the Laguerre–Pólya class
Authors: Nguyen Thu Hien , Vishnyakova Anna 
Published: July 2023

Abstract
We find the intervals [α, β(α)] such that if a univariate real polynomial or entire function f (z) = a0 + a1z + a2z 2 + · · · with positive coefficients satisfy the conditions a 2 k−1 a k−2 a k ∈ [α, β(α)] for all k ≥ 2, then f belongs to the Laguerre– Pólya class. For instance, from J.I. Hutchinson’s theorem, one can observe that f belongs to the Laguerre–Pólya class (has only real zeros) when qk(f) ∈ [4, +∞). We are interested in finding those intervals which are not subsets of [4, +∞).
MSC Classification: 30C15; 30D15; 30D35; 26C10
Therapeutic Potential of Lactoferrin-Coated Iron Oxide Nanoparticles for Targeted Hyperthermia in Gastric Cancer
Authors: Attri Komal , Chudasama Bhupendra , Mahajan Roop , Choudhury Diptiman 
Published: July 2023

Abstract
Lactoferrin (LF) is a non-heme iron-binding glycoprotein involved in the transport of iron in blood plasma. In addition, it has many biological functions, including antibacterial, antiviral, antimicrobial, antiparasitic, and, most importantly, antitumor activities. In this study, we have investigated the potential of lactoferrin-iron oxide nanoparticles (LF-IONPs) for the treatment of gastric cancer. The study confirms the formation of LF-IONPs with a spherical shape and size of 5 ± 2 nm, embedded in the protein matrix. FTIR and RAMAN analysis revealed that the Fe-O bond stabilized the protein particle interactions. Further, we conducted hyperthermia studies to ascertain whether the proposed composite can generate a sufficient rise in temperature at a low frequency. The results confirmed that we can achieve a temperature rise of about 7 ºC at 242.4 kHz, which can be further exploited in treating gastric cancer. The particles were further tested for their anticancer activity on AGS cells, with and without hyperthermia. Results showed that LF-IONPs significantly enhanced cytotoxicity and inhibition of migration in LF-IONPs treated cells compared to control cells, with the most inhibition seen after 36 h of treatment. These findings suggest LF-IONPs potential for targeted hyperthermia treatment.
Prenatal cannabis exposure alters offspring DNA methylation at genes involved in neurodevelopment, across the life course
Authors: Osborne Amy , Noble Alexandra , Adams Alex , Satsangi Jack , Boden Joseph 
Published: July 2023

Abstract
Prenatal cannabis exposure (PCE) is of increasing concern globally, due to the potential impact on offspring neurodevelopment, and its association with childhood and adolescent brain development and cognitive function. However, a lack of research addressing the molecular impact of PCE means that it is not known whether PCE can be considered causative for adverse child neurodevelopment, or whether it is simply correlational. To address this knowledge gap, here we present epigenome-wide association study data across multiple timepoints, examining the effect of PCE and co-exposure with tobacco using two longitudinal studies, the Avon Longitudinal Study of Parents and Children (ALSPAC) and the Christchurch Health and Development Study (CHDS) at birth (0 y), 7 y and 15-17 y (ALSPAC), and ~27 y (CHDS). Our findings reveal genome-wide significant DNA methylation differences in offspring at 0 y, 7 y, 15-17 y and 27 y associated with PCE alone, and co-exposure with tobacco. Importantly, we identified significantly differentially methylated CpG sites within the genes LZTS2, NPSR1, NT5E, CRP2, DOCK8, COQ5 and LPAR5 that are shared between different time points throughout development in offspring. Notably, functional pathway analysis showed enrichment for differential DNA methylation in neurodevelopmental and schizophrenia pathways, and this was consistent across all timepoints in both cohorts. Given the increasing volume of epidemiological evidence that suggests a link between PCE and adverse neurodevelopmental outcomes in exposed offspring, this work highlights the need for further investigation into PCE, particularly in larger cohorts.
Evaluation of the impact of coal mining on surface water in the Boesmanspruit, Mpumalanga, South Africa
Authors: Dzhangi Thandi R. , Atangana Ernestine 
Published: July 2023

Abstract

Surface water quality has major environmental and socioeconomic consequences, notably in terms of the country’s long-term fresh water supply. This study aimed at assessing the current state of water quality and status of the Boesmanspruit in a coal mining environment. The study used historical water quality data for a period of five years. Aluminium, calcium, iron, manganese, magnesium, sodium, sulphate, electrical conductivity, pH and total dissolved solids were the water quality variables selected for the study. The water quality was evaluated against South African resource quality objectives, the South African water quality guidelines, Vol. 5 and 7, and the water quality indices (WQI) of the Canadian Council of Ministers of the Environment. The following parameters were above the prescribed thresholds: pH, total dissolved solids, electrical conductivity, sulphate, manganese and iron. The data was analysed using such as the CCME-WQI, the comprehensive pollution index (CPI) and multivariate statistics. The CCME-WQI results showed that monitoring locations GR S26 and GR S21 near mining activities had poor water quality (40–44), whereas CPI also had similar category results for the monitoring points, indicating that they were heavily polluted (2.4–4.8). The WQI showed that if certain variables, such as aluminium, iron, magnesium, sulphate, electrical conductivity and total dissolved solids, exceed the permissible range, the water quality would deteriorate in accordance with the CPI classification. Therefore, the CPI was the best way to categorise the water quality. The principal component analysis and cluster analysis identified two primary sources of pollution which are anthropogenic and natural. The utilisation of statistical analysis proved to be effective in determining the ideal quantity of significant variables within the study area. The study recommends low-cost options for reducing the effects of acid mine drainage, which includes passive mine water treatment methods using artificial wetlands.
Effectiveness of the Malaise trap and sweep net sampling in sawfly research (Hymenoptera: Symphyta)
Authors: Haris Attila , Vidlička Lubomír , Majzlan Oto , Roller Ladislav 
Published: July 2023

Abstract
Malaise traps and sweep nets are commonly used to study sawfly fauna, seasonality and communities. Here we analyse a large dataset obtained with these methods in Slovakia and Hungary over the last two and a half decades. The dataset included collections from twenty-one sites, each covering the entire growing season, eleven of which were obtained with the Malaise trap and ten with the sweep net. We conclude that both methods are suitable for faunistic studies of sawflies (Hymenoptera, Symphyta), although they may lead to certain biassed results for some Symphyta groups. Special attention should be paid to Siricidae, Orussidae, Xiphidriidae and Cimbicidae, which were only weakly recorded with both methods. Argidae, Blennocampinae, Dolerinae and Tenthredininae were underrepresented in the Malaise trap samples and Allantinae in the sweep net samples. Both methods gave equally good results in measuring species richness in a one-year study. Ideally, they should be used together as they complement each other well. The net method has a great advantage in determining the exact population density. In contrast, the Malaise trap collections were often heavily dominated by only a few species, with males being preferentially trapped. It can be used preferentially in the study of seasonal flight activity.
Factors of certain basic hypergeometric sums
Authors: Cao Jian , Guo Victor J. W , Yu Xiao 
Published: July 2023

Abstract
We prove that certain truncated basic hypergeometric series contain the factor Φn(q)2, where Φn(q) is the n-th cyclotomic polynomial. This result may be regarded as a generalization of Theorem 1.1 in [J. Math. Anal. Appl. 476 (2019), 851–859].
2010 Mathematics Subject Classifications: 33D15, 11A07, 11B65
Contemporary Graffiti as a Tool for Studying Prehistoric Art. A Classification Attempt
Authors: Zagorov Vasil , Hristov Hristo 
Published: July 2023

Abstract
This article aims to present a classification of contemporary graffiti to support the study of Prehistoric art. The classification is based on two-year field observations of both completed and newly created works of contemporary graffiti and street art. The classification is oriented to the result of the creative act in view of its communicative significance. The scientific approach does not aim to create direct parallels between specific artistic samples, but to study the basic principles, stages, and starting points of the creative act. Thanks to the classification, on the principle of analogy, a series of questions have been prepared, and addressed to archaeologists, cultural anthropologists, and art critics with a greater degree of training in the field of Prehistoric art. The current research seeks to explain some aspects of Prehistoric art through modern graffiti. Of course, this approach is not intended to negate the scientific hypotheses and results achieved so far in the field of Archaeology and History of Art but to help scholars of prehistoric art study to ask or reformulate a series of questions that will contribute to a more comprehensive view and understanding of Prehistoric art.
Teaching and Learning Optimization method for multi- channel wireless mesh networks with MIMO links
Authors: Kavitha P. , Renugadevi R. , kumar P. Ranjith 
Published: July 2023

Abstract
Wireless Mesh Networks are a very attractive new field of research. Mesh networks are low cost, easily deployed, and provide high performance solution to broadband network access. Multiple Inputs and Multiple Outputs (MIMO) is one of the radio technology breakthroughs for increasing network capacity to obtain the full benefits in wireless mesh networks. The proposed research investigates the network routing, channel assignment, capacity of MIMO channel with number of transmit and number of receive antennas in wireless mesh networks. This paper also focuses an intelligent Teaching-Learning-based Optimization (TLO) algorithm to find the optimal network routing path between source and destination for Wireless Sensor Network (WSN). Compared with other routing metrics, the simulation results show that the proposed algorithm converged quickly and reached the optimal solution with minimal time and also improve the network performances.