bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carboxyhaemoglobin levels in infants with hypoxic ischaemic encephalopathy
Authors: Jenkinson Allan , Zaidi Sarah , Bhat Ravindra , Greenough Anne , Dassios Theodore 
Published: August 2023

Abstract

Objectives
Hypoxic ischaemic encephalopathy (HIE) is associated with oxidative stress. A potential marker of oxidative damage is carboxyhaemoglobin (COHb) which is the product of the reaction between carbon monoxide and haemoglobin and is routinely assessed on blood gas analysis. Our objective was to test the hypothesis that higher COHb levels would be associated with worse outcomes in infants treated for HIE.

Methods
A retrospective, observational study was performed of all infants who received whole body hypothermia for HIE at a tertiary neonatal intensive care unit between January 2018 and August 2021. For each participating infant, the highest COHb level per day was recorded for days one, three and five after birth.

Results
During the study period, 67 infants with a median (IQR) gestational age of 40 (38–41) weeks underwent therapeutic hypothermia for HIE. The median (IQR) COHb level on day three was higher in infants without electroencephalographic seizures (1.4 [1.1–1.4] %) compared with infants with seizures (1.1 [0.9–1.3] %, p=0.024). The median (IQR) COHb on day five was higher in infants without MRI brain abnormalities (1.4 [1.2–1.7] %) compared with infants with MRI abnormalities (1.2 [1.0–1.4] %, p=0.032). The COHb level was not significantly different between the nine infants who died compared to the infants who survived.

Conclusions
COHb levels were higher in infants with HIE without seizures and in those with normal MRI brain examinations. We suggest that carbon monoxide has a potential protective role in HIE.
Management of the COVID-19 Infodemic in Asian Countries: What Should We Know? (Systematic Review)
Authors: Damerchiloo Mansoureh , Baghalha Fatemeh 
Published: August 2023

Abstract
The spread of fake news on Covid19 is causing public unrest and suspicion among citizens, which is a challenge for countries facing the pandemic. Countries, governments, and organizations worldwide are putting more effort into combating the infodemic along with finding an effective treatment for Covid19. To collect and summarize the strategies used for combating it and the challenges of managing the infodemic among Asian countries, this systematic review examined 42 articles matched with the inclusion and exclusion criteria by researchers. It was found that the techniques employed by governments to control the infodemic can be classified into three categories: educational activities, technical activities and tool production, and legal activities, and the most challenging way of combatting misinformation is to use social media filtering and legal action.
miR-199a-5p inhibits aortic valve calcification by targeting ATF6 and GRP78 in valve interstitial cells
Authors: Chu Heng , Fan XingLi , Zhang Zhe , Han Lin 
Published: August 2023

Abstract
Calcific aortic valve disease (CAVD) is an important cause of disease burden among aging populations. Excessive active endoplasmic reticulum stress (ERS) was demonstrated to promote CAVD. The expression level of miR-199a-5p in patients with CAVD was reported to be downregulated. In this article, we aimed to investigate the function and mechanism of miR-199a-5p in CAVD. The expression level of miR-199a-5p and ERS markers was identified in calcific aortic valve samples and osteogenic induction by real-time quantitative polymerase chain reaction (RT-qPCR), immunohistochemistry, and western blotting (WB). Alizarin red staining, RT-qPCR, and WB were used for the verification of the function of miR-199a-5p. The dual luciferase reporter assay and rescue experiment were conducted to illuminate the mechanism of miR-199a-5p. In our study, the expression level of miR-199a-5p was significantly decreased in calcified aortic valves and valve interstitial cells’ (VICs) osteogenic induction model, accompanying with the upregulation of ERS markers. Overexpression of miR-199a-5p suppressed the osteogenic differentiation of VICs, while downregulation of miR-199a-5p promoted this function. 78 kDa glucose-regulated protein (GRP78) and activating transcription factor 6 (ATF6), both of which were pivotal modulators in ERS, were potential targets of miR-199a-5p. miR-199a-5p directly targeted GRP78 and ATF6 to modulate osteoblastic differentiation of VICs. miR-199a-5p inhibits osteogenic differentiation of VICs by regulating ERS via targeting GRP78 and ATF6.
A19-saponin–modified polymethyl methacrylate base denture composites: antimicrobial, mechanical and water absorption potentials
Authors: Azeez Taofik Oladimeji , Iroh Grace Onyinyechi , Odetunde Daniel Segun , Egbuonu Amaka Tessy , Agbasi Patrick Ugochukwu 
Published: August 2023

Abstract
The increased growth of Candida albicans (C. albicans) with allergy reaction of MMA remains an issue of concern among denture wearers. C. albicans growth inhibition, mechanical and water absorption potentials of extracted A19-saponin–commingled PMMA denture base composites were investigated. Soxhlet extraction technique for defatting of Dialium guineense (D. guineense) stem powder was used with ethanol to extract A19-saponin. Fungicidal inhibition concentration of A19-saponin extract of D. guineense was determined. PMMA denture base was prepared with incorporation of A19-saponin at different concentrations of obtained 23.2 % yield. The mechanical and water absorption properties were determined. The minimum and maximum fungicidal inhibition concentrations and susceptibility of 25 and 100 % for extracted A19-saponin were obtained, respectively. PMMA, MMA and extracted A19-saponin of ratio of 30 g: 5 ml: 5 ml denture was optimally fabricated. A19-saponin increased the impact strength and hardness by 352.94 and 11.54 % with reduced water absorption by 82.85 %. Thus, A19-saponin as an additive improved quality of denture.
Equilibrium stability of dynamic duopoly Cournot game under heterogeneous strategies, asymmetric information, and one-way R&D spillovers
Authors: Long Jianjun , Wang Fenglian 
Published: August 2023

Abstract
Bounded rationality, asymmetric information, and R&D spillovers are widely existed in monopoly markets, and they have been researched separately by a large number of literatures; however, there are few works that discussed both R&D spillovers and asymmetric information in oligopolistic games with bounded rational firms. Considering that R&D spillovers only flow from the R&D leader to the R&D follower, a duopoly Cournot game with heterogeneous expectations and asymmetric information is presented. In our model, a firm with private information of his marginal cost is designed, and the coefficient of R&D spillovers is introduced. Interesting findings show the following: (i) In a static duopoly Cournot game with perfect rationality, the equilibrium output of firm 1 with private information is negatively related to R&D spillovers and the probability of high marginal cost, while firm 2’s equilibrium output is positively correlated with them. (ii) In a dynamic duopoly Cournot game with asymmetric information and heterogeneous expectations, if firms adopt adaptive expectation and naïve expectation respectively, the Nash equilibrium is always globally asymptotically stable; if they use adaptive expectation and gradient dynamical expectation respectively, the Nash equilibrium tends to be locally asymptotically stable under certain conditions. Furthermore, the bigger the probability of high marginal cost or R&D spillovers are, the more volatile the monopoly market is, while higher technology innovation efficiency (TIE) of firm 1 is conducive to the stability of the product market. Our study would have theoretical and practical significance to the technological innovation activities of homogeneous products in oligopoly markets.
The Warthin-like variant of papillary thyroid carcinomas: a clinicopathologic analysis report of two cases
Authors: Zhao Xing , Zhang Yijia , Hao Pengyu , Zhao Mingzhen , Shen Xingbin 
Published: August 2023

Abstract

Obejectives
Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma, comparising various subtypes including classical PTC (accounting for approximately 55–65 % of cases) and several variants. The identified variants include papillary microcarcinoma, encapsulated variant, follicular variant, diffuse sclerosing variant, tall cell variant, columnar cell variant, cribriform-morular variant, and Warthin-like variant (WLV-PTC). WLV-PTC is a rare malignant neoplasm.

Case presentation
The present study introduced two cases of WLV-PTC from Affiliated Hospital of Chengde Medical College in retrospect. The macroscopic characteristics, histological feature, immunophenotyping, gene mutations, local invasion, and distant metastasis of the tumors were observed, and the relevant literature on WLV-PTC was reviewed. The tumor cells exhibited nuclear the characteristics similar to those of classic papillary thyroid carcinoma. Immunohistochemical analysis showed strong positivity for thyroid transcription factor 1, cytokeratin 19, Galectin-3, and CK, weak positivity for thyroglobulin, and the Ki-67 proliferation index ranging from 5 to 10 %. Gene mutation analysis revealed that Case 1 had a BRAF V600E mutation, whereas Case 2 had a wild-type mutation. WLV-PTC has histological features similar to those of Warthin tumor originating from salivary gland.

Conclusions
The prognosis of WLV-PTC is similar to that of conventional PTC of comparable size and stage.
Reality Is a Joke
Authors: Burt Tristan 
Published: August 2023

Abstract
I argue that the unthought philosophical bias in favor of seriousness and sense rather than nonsense and joking blocks the path to reality. Because of this bias we obsess over significant signs and forget to consider what signs are signs of; we lose sight of the forest because there are so many interesting trees. Through a thoroughgoing interrogation of signs or appearances, we can reveal what it is that all signs present or represent: the underlying real joke. Once the “sensible bias” of philosophy is overcome and the sense of nonsense restored, we can reveal the object of ontology—the Kantian noumenon—and, therefore, understand the necessary order of signification or representation. In this way, I argue, we can come to be equally amused by all appearances, recognizing that their deceptive character is necessitated by the playful nature of the real thing which, qua joke, provokes amusement.
Future perspectives of biopolymeric industry
Authors: Biswal Trinath 
Published: August 2023

Abstract
Because of some specific properties such as hydrophilicity, poor mechanical strength, barrier properties, and other characteristics, biopolymers and biocomposite materials are not suitable for various important industrial applications. In the last few decades, the demand for biopolymers and their composites has increased continuously due to the extensive use of fossil resources or stock resources. Hence, eco-friendly biomaterials are highly essential for maintaining the sustainability of the environment. Now, biomaterials are considered highly promising materials that can be used as proper substitutes for fossil-based synthetic polymers and their composites through proper modification of the biopolymers. Recently, a novel non-biodegradable biomaterial (polythioesters) has been developed through microbial fermentation. Researchers throughout the globe are now developing improved biocomposite materials by incorporating different fillers in the nanoscale range that exhibit adequate mechanical properties and can be designed as future biomaterials that can replace traditional plastics. Now biopolymers and bionanocomposites are used noticeably in many countries throughout the world for food packaging, cosmetics, automobile industries, water purification, tissue engineering, textile industries, electronic industries, etc. For the industrialization of biobased polymeric materials and bionanocomposite materials, they should be synthesized in a sophisticated way by using green technology with improved geometry, good control in internal architecture, mechanical properties, and porosity. Chitin, alginate, pectin, zein, chitosan, poly-glutamic acid (-PGA), and other natural biopolymers are now found to be the future materials for various bioplastic industries. However, the future prospects of the biopolymer industry still pose challenges for industrialization and commercialization and should not be overlooked lightly.
Foot drop in children with newly diagnosed type 1 diabetes: three case reports
Authors: Chrzanowska Joanna , Seifert Monika , Salmonowicz Barbara , Zubkiewicz-Kucharska Agnieszka 
Published: August 2023

Summary
The etiology of foot drop is diverse from various diseases to mechanic injuries and includes neuropathy of the peroneal nerve. Peroneal neuropathy might also be one of the forms of diabetic neuropathy, very rarely reported as the first sign of diabetes. We describe three cases of children with newly diagnosed type 1 diabetes (TID) who developed unilateral peroneal nerve palsies and tibial nerve palsies, presenting clinically as a foot drop. In two of our cases, the symptoms of foot drop occurred shortly after starting treatment for severe diabetes ketoacidosis. In the third patient, food drop was a reason for the initial medical consultation, but eventually, TID was diagnosed. The presented cases highlight that neuropathy can be observed not only as a chronic complication of T1D, but it can also appear at the time of disease manifestation. The incorrect position of the lower limb during a keto coma may contribute to the development of neuropathy.

Learning points

Neuropathy can be observed not only as a chronic complication of type 1 diabetes (T1D), but it can also appear at the time of disease manifestation.

The incorrect position of the lower limb causing external pressure during a keto coma may contribute to the development of neuropathy.

It is important to examine the glycemia in patients with acute peroneal neuropathy, as this kind of peripheral neuropathy can be associated with newly diagnosed T1D. Normalization of glycemia might lead to rapid neuronal recovery.
Development of an acrylic emulsion paint added with cellulosic dispersion treated with an electron beam accelerator
Authors: Nascimento Fernando Codelo , Munhoz Pedro Márcio , Nascimento Luiz Fernando Núbile , Calvo Wilson Aparecido Parejo 
Published: August 2023

Paint is a prevalent type of surface of coating well known to most peoPaint is a prevalent type of surface of coating well known to most people. It is an easy-to-apply product, with excellent physical and chemical resistance and a wide range of applications. The function of a paint is to protect and beautify amongst other properties. Paints are formed using five components: resin, pigments, fillers, solvents and additives. This work deals with a specific type of paint, composed of a water-based acrylic emulsion, whose film formation is by coalescence and used to coat walls and other surfaces. The aim of this innovative research was to evaluate the effect of the addition of cellulosic dispersion of waste paper tissues treated by electron beam irradiation to an acrylic emulsion-based paint. The methodology used was a case study carried out at the Nuclear and Energy Research Institute that consisted of adding aqueous dispersions of cellulosic wipes with mass concentrations varying from 0.1% to 10% in deionized water, and treated by electron beam processing with absorbed doses from 5 kGy to 50 kGy. The results obtained followed the parameters of the Abrafati Sectorial Quality Program. The main sample parameters analyzed were specific density, which reached an average of 1.35 g/cm3; and covering power, whose value of 93.55% was above the specified limit (minimum of 90%). Among other results obtained, improvements in appearance, applicability and functionality were significant. It was concluded that this research constitutes an incremental improvement to the acrylic emulsion paints segment, and environmental sustainability, through the reuse of cellulosic tissue residues
Masz tę MOC! Małymi krokami do celu. Innowacja pedagogiczna na miarę XXI wieku!
Authors: Giziewska Marta , Aksamit Emilia 
Published: August 2023

Cel:
Celem artykułu jest prezentacja autorskiego modelu innowacji pedagogicznej Masz tę MOC! Marz! Odkrywaj! Ustalaj Cele!
Omówione koncepcje:
Opisywany w artykule, model innowacji oparty jest na filozofii Kaizen, która zakłada dochodzenie do wyznaczonych celów poprzez małe kroki. W ramach prezentowanego modelu innowacji realizowane są trzy kluczowe kroki. Pierwszy krok: marz, drugi: odkrywaj (swoje mocne strony), trzeci: ustalaj cele, które kolejno następują po sobie. Realizacja wskazanych kroków pozwala podnieść poziom kompetencji uczniów i uczennic klas 4-8 w obszarach planowania samorealizacji, rozpoznawania własnych zasobów, sprawczości i pozytywnego obrazu siebie niezbędnych do definiowania własnych potrzeb oraz poznawania sposobów ich realizacji.
Wyniki i wnioski:
Innowacje pedagogiczne stanowią kluczowy element szkolnej rzeczywistości, który umożliwia wdrożenie działań stanowiących odpowiedź na aktualne potrzeby uczniów i uczennic. W artykule zaprezentowano wyniki ewaluacji opisywanego modelu innowacji wskazując nie tylko na jego skuteczność ale i też atrakcyjność oraz użyteczność, w oparciu o oceny użytkowników innowacji (nauczycieli i nauczycielek) oraz jej odbiorców (uczniów i uczennic).
Wartość poznawcza:
W artykule zaprezentowano kompleksowy opis autorskiego modelu innowacji, w tym jego podstawy teoretyczne, cel, zakres tematyczny, metody dydaktyczne oraz wyniki ewaluacji. Prezentowane treści łączą ze sobą przestrzenie teorii, empirii i praktyki pedagogicznej.
Kategoria estetyczna niesamowitości w literaturze jako pierwiastek czegoś nie z tego świata
Authors: Kozłowska Karolina 
Published: August 2023

Cel: Celem niniejszego artykułu jest przedstawienie kategorii niesamowitości – jej genezy i cech szczególnych, a także tego, jak objawia się w poszczególnych tekstach literackich.
Omówione koncepcje: Analiza była oparta na szczegółowym badaniu wybranych tekstów literackich w oparciu o kategorie grozy i makabry, surrealizmu, a także teorie o lokalności.
Wyniki i wnioski: Różni autorzy w odmienny sposób, ale chętnie sięgali po kategorię niesamowitości. Amerykański pisarz Edgar Allan Poe posługiwał się nią, a także grozą i makabrą, aby wywołać w czytelniku silne emocje. Nona Fernández za pomocą kategorii niesamowitości stworzyła swoistą mieszankę dwóch gatunków – reportażu i powieści, gdzie posługuje się wyobraźnią, aby oddać horror dyktatury Augusto Pinocheta w Chile. Autorzy esejów zebranych w tomie Nieswojość pokazują jak niesamowitą krainą jest Dolny Śląsk. Tworzy on obraz pełen sprzeczności, w którym miesza się to, co stare i niemieckie, z tym, co nowe i polskie.
Wartość poznawcza: W artykule zaprezentowano szerokie spojrzenie na kategorię niesamowitości. Pokazane zostały jej różnorodne oblicza i nieoczywiste powiązania z innymi teoriami.
Postrzeganie pracy aktorskiej wśród osób do 35. roku życia
Authors: Dziegieć Agata 
Published: August 2023

Abstrakt
Cel badań: Celem badania było przyjrzenie się temu, w jaki sposób osoby młode do 35 roku życia postrzegają pracę aktorską rozumianą jako działania artystyczne podejmowane przez twórców podczas grania w filmie, teatrze lub serialu.
Metoda badań: Skonstruowano kwestionariusz, w który, zastosowano dyferencjał semantyczny Osgooda (1952).Osoby badane decydowały w odniesieniu do każdej z 20 dwubiegunowych skal, które z przeciwstawnych określeń lepiej opisuje pracę aktorską. Respondenci określali swój stosunek do podanych stwierdzeń, wybierając jedną z wartości liczbowych na sześciostopniowej skali Likerta.
Wyniki badań: Wymiary, który uzyskały najwyższą zgodność wśród osób badanych to: twórcza – odtwórcza, beztroska – stresująca, dostępna dla niektórych – dostępna dla każdego, lekka – ciężka, nudna – ciekawa, artystyczna – rzemieślnicza, zwyczajna – wyjątkowa, istotna społecznie – społecznie nieistotna. Ponad 50% osób badanych uznało, że pracę aktorską lepiej lub znacznie lepiej opisują określenia takie jak: twórcza, stresująca, dostępna dla niektórych, ciężka, ciekawa, artystyczna, wyjątkowa, istotna społecznie. Pozostałe wymiary charakteryzowały się większą rozbieżnością wyników.
Wnioski: Współczesna kultura, w której szeroko obecne są środki masowego przekazu takie jak telewizja, czy platformy streamingowe, stwarza nowe przestrzenie do funkcjonowania pracy aktorskiej. Wśród badań nad aktorstwem na gruncie polskim brakuje danych, które pokazywałyby jaki status społeczny ma obecnie praca aktorek i aktorów. Przedstawione badanie jest pierwszym, które podejmuje próbę odkrycia i przedstawienia obrazu pracy aktorskiej wśród osób młodych mieszkających w Polsce.
Sedimentary P- and S-Wave Velocity Structures in Shimousa Region of Kanto Basin Determined from Joint Autocorrelation and Receiver Function Analysis
Authors: Chimoto Kosuke 
Published: August 2023

ABSTRACT
To determine the P- and S-wave velocities (VP and VS, respectively) of the sedimentary layers in the Shimousa region of the Kanto basin, Japan, the autocorrelations of P and S waves and the receiver function (RF) for the local earthquakes at the strong-motion stations in the region were jointly analyzed. Because the autocorrelations and RF were insensitive to the event location, the stacked functions for various events captured clear P and S reflections and the Ps phase at the bedrock of the basin. The PpPs phase was also clearly observed at some stations in the region. The arrival times of the P and S reflections and the Ps phase depended on the station. These phases arrived earlier at the northern and eastern parts of the region, and later at the southern and western parts. This trend shows good agreement with that expected from the 3D velocity structure model developed by the Japan Seismic Hazard Information Station. The VP, VS, and thickness (H) values were then estimated from the histogram of the H–V stack for the P and S autocorrelations and the Ps and PpPs phases in the RF. VP, which is less sensitive than VS and H, was not always well determined at some stations, whereas VS and H were well estimated with high resolution. It was found that the resolution depends on the station location in the region. This dependence could be caused by the appearance of clear phases in the functions.