bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sobre os espaços-tempos de brincar na escola: o que nos comunicam os brincates?
Authors: Santos Helma Costa dos , Fernandes Maria Lídia Bueno 
Published: September 2023

A presente pesquisa traz um recorte de um estudo mais amplo sobre as brincadeiras infantis nos tempos-espaços do ambiente escolar. Esse delineamento, que teve seu apoio no pressuposto de que as brincadeiras infantis são atividades que dizem muito da vida das crianças em seus espaços vivenciais, objetivou compreender como as crianças agem no contexto escolar em relação aos espaços-tempos das atividades brincantes, as expressões culturais relacionadas às brincadeiras, além de analisar aspectos institucionalizados que se entremeiam a esse processo. De viés qualitativo, com a adoção de procedimentos e levantamentos de questões inspiradas na etnografia, empreenderam-se, além da pesquisa em campo, revisão de literatura e discussão dos principais conceitos teóricos aplicados. A base teórica foi ancorada nos postulados dos Estudos Sociais da Infância, buscando dialogar com a Geografia e Sociologia das Infâncias, tendo as análises sido construídas com a contribuição de diferentes campos do conhecimento e da teoria histórico-cultural. Os achados indicam que, por meio das brincadeiras, além do enraizamento na cultura infantil, as crianças convertem espaços em lugares, empregando-lhes suas vivências e experiências, transformando-os de acordo com as suas necessidades brincantes que, por vezes, estão em desacordo com as lógicas adultas estabelecidas.
EVALUASI PROSEDUR PENJUALAN DAN PENERIMAAN KAS (STUDI PADA PT. ASTRA INTERNATIONAL, Tbk – AUTO2000 MALANG SUTOYO)
Authors: Prameswari Gita Labaika 
Published: September 2023

Penelitian yang dilakukan bertujuan untuk mengetahui sistem dan prosedur penjualan dan penerimaan kas dalam mendukung pengendalian intern pada PT. Astra International, Tbk AUTO 2000 Malang Sutoyo dengan memperhatikan penerapan komputerisasi dan unsur-unsur pengendalian intern. Jenis Penelitian yang digunakan yaitu penelitian deskriptif dengan menggunakan pendekatan kualitatif. Fokus yang diambil dalam penelitian yaitu sistem dan prosedur penjualan dan penerimaan kas pada penjualan unit kendaraan, dan penjualan sparepart kendaraan secara kredit, serta pengendalian intern pada PT. Astra International, Tbk AUTO 2000 Malang Sutoyo, yang beralamat di Jalan Letjend Sutoyo No. 25 Malang. Tahapan analisis data yang dilakukan yaitu, menganalisis sistem akuntansi dan prosedur penjualan dan penerimaan kas serta penerapan komputerisasi dalam mendukung pengendalian intern dengan memperhatikan unsur-unsur pengendalian intern kemudian mengevaluasinya.
Hasil dari penelitian menunjukkan bahwa sistem dan prosedur penjualan dan penerimaan kas pada PT. Astra International, Tbk AUTO 2000 Malang Sutoyo sudah diterapkan dengan baik, akan tetapi masih terdapat beberapa kelemahan. Kelemahan tersebut antara lain pada sistem dan prosedur penjualan dan penerimaan kas masih terdapat beberapa perangkapan fungsi serta pada pengendalian intern yaitu rotasi karyawan belum dilakukan secara rutin dan tidak ada pemeriksaan yang dilakukan secara mendadak serta permasalahan pada sistem jaringan pada perusahaan. Saran yang dapat diberikan kepada PT. Astra International, Tbk AUTO 2000 Malang Sutoyo yaitu dilakukan pemisahan fungsi dan rotasi karyawan dilakukan secara rutin serta diadakan pemeriksaan secara mendadak untuk meminimalisir adanya kecurangan dan juga sebaiknya perusahaan menerapkan metode load balancing dengan dua atau lebih ISP yang berbeda sehingga meminimalisir terjadinya beban overload pada satu jalur koneksi.
Aligning Total Quality Management, Continuous Improvement for Process Performance: An Empirical Review
Authors: Ugwu Kelechi 
Published: September 2023

Purpose: The fundamental goal of this research is to develop a conceptual framework for performance, continuous process improvement, and total quality management.
Design/Methodology/Approach: Exploring the literature on total quality management and other variables in connection to various relationships has been the subject of recent investigations.
Findings: This paper provides an introduction of total quality management, explains how it transforms into a sophisticated strategy employed in modern businesses, and discusses the literature-based research that has been done in this field. This study suggests that total quality management, a concept popularized by Deming, be investigated in a range of industries in order to enhance product quality, reduce waste, and increase productivity.
Research Restrictions/Implications: This study is an integrative evaluation of the prior research on the idea of overall quality management and its connection. Future researchers are urged to make use of descriptive survey and empirical technique to generalize its findings.
Originality/Value: To reflect comprehensive quality management, continuous improvement, and process performance, this study created a conceptual framework and model. The author created a summary table to display earlier research on the subject, including authors, topics, countries, methodologies, and findings. In light of the aforementioned, the researcher filled a knowledge gap.
Culture in Russian as a foreign language (RFL) textbooks in Italian universities: Critically analyzing concepts of culture and intercultural competence
Authors: Torresin Linda 
Published: September 2023

This paper examined the representation of culture in Russian as a foreign language (RFL) textbooks to understand the problem of creating a theory of intercultural textbooks, with Italy as a case study. The four most popular RFL textbooks used by first-year students in Italian universities were studied: Poyekhali, Molodets, Mir tesen, and Davayte. A comparative content analysis of the chosen sample was performed to test how Russian culture is represented in RFL textbooks. The results reveal that such textbooks reflect only a partial and sometimes stereotypical image of Russian culture, with a strong correlation between ideologies and bias derived from RFL theories and textbook creation. In other words, these textbooks convey essentialist and/or reductionist views of the culture of Russia (e.g., poor attention paid to the Russophone dimension, stereotypes, and lack of opportunities for intercultural dialogue). The cultural topics contained in the textbooks evaluated do not quite contribute but rather hinder the formation of students' intercultural communicative competence. Therefore, it is argued that the content of an RFL textbook should help students create complex, multilayered notions of Russian and Russophone cultures for themselves.
Projeto de vida: a busca de sentido no contexto educacional
Authors: Fatima de Souza Aline , Franco Gisele de Rezende 
Published: September 2023

Resumo
A disciplina Projeto de Vida oferece a possibilidade de trabalhar perspectivas bastante salutares com os estudantes do Novo Ensino Médio. Alguns trabalhos investigativos, identificados neste estudo exploratório, acerca dos primeiros resultados desta nova empreitada, já foram publicados e os dados evidenciam que os jovens necessitam de nutrientes que os ajudem a nortear seus caminhos e que sustentem o sentido da vida na sua singularidade. Ter um horário na escola para pensar sobre si mesmo, os outros e o mundo, poder buscar a compreensão sobre os relacionamentos pelos quais são atravessados e imaginar roteiros possíveis após o término da escola, é imprescindível a todos os jovens mediante as tarefas do desenvolvimento e aos desafios na atual conjuntura. Faz-se importante levar em consideração a capacitação de professores para esta jornada, assim como a proposta da licenciatura em Psicologia nesta atuação. Para tanto, traz-se aqui duas formas de intervenção da Psicologia frente à nova disciplina Projeto de Vida: tanto no tocante ao papel do Psicólogo Escolar e Educacional, quanto do Psicólogo licenciado, numa atuação que venha a promover o desenvolvimento integral dos escolares no Ensino Básico. Por isso, propôs-se a abordagem da Psicologia Positiva, de Martin Seligman, no intuito de dar embasamento às discussões e refletir sobre a relevância do Desenvolvimento Positivo dos Jovens para alcançar a promoção do bem-estar na juventude diante dos processos de escolarização.
Palavras-chave: Projeto de vida. Sentido da vida. Bem-estar. Escolarização.
Ecological engineering in low land rice for brown plant hopper, Nilaparvata lugens (Stål) management
Authors: Yele Yogesh , Chander Subhash , Suroshe Sachin S. , Nebapure Suresh , Tenguri Prabhulinga , Pattathanam Sundaran Arya 
Published: September 2023

Rice field bunds and edges can act as near crop habitats, available for planting flowering plants to attract and conserve the natural enemies. We evaluated the effect of ecological engineering on the incidence of Brown Planthopper (BPH), Nilaparvata lugens (Stål) (Hemiptera; Delphacidae) and the abundance of its predators in the rice variety Pusa Basmati-1121. Plots included the oilseed crops viz. sesamum, sunflower and soybean, with plantings of flowering crops marigold, balsam and gaillardia as bund flora around the edges of rice plots. Ecologically engineered plots contained both crops+flowers and resulted in a significantly reduced BPH population per hill in rice plots for 2019 (6.3) and 2020 (9.4) compared to the control plots (9.8 and 14.4). Ecologically engineered plots also witnessed the delayed appearance of BPH during each growing season. Peak BPH populations are lower in the ecologically engineered plots than in the control grounds. Furthermore, the activity of natural enemies, viz., spiders, mirid bugs and rove beetles was the highest in rice fields planted with oilseed crops like sesamum, sunflower and soybean. Olfactory response studies showed that the attraction response of spiders toward sesamum and balsam leaves was more significant than in other crop plants. Rice yield was enhanced in plots planted with crops+flowers during both seasons compared to control plots. Planting of oilseed crops plants such as sesamum, sunflower and soybean with flowering crops such as marigold, balsam and gaillardia as bund flora on the bunds around the main rice field enhanced the natural enemy activity, suppressed the planthopper population, and increased yields. Based on the results, we recommend including ecological engineering techniques as one of the management components in the Integrated Pest Management programme for rice crops.
Clinical value of hemoglobin, albumin, lymphocyte, and platelet indexes in predicting lymph node metastasis and recurrence of endometrial cancer: a retrospective study
Authors: Xiong Ying , Yong Yuanyuan , Wang Yanhua 
Published: September 2023

Objective
To study the clinical importance of hemoglobin, albumin, lymphocyte, and platelet (HALP) indexes in predicting lymph node metastasis and recurrence of endometrial cancer.

Methods
From July 2016 to July 2020, 158 patients suffering from endometrial cancer who visited the gynecology department of General Hospital of Ningxia Medical University from were collected. Employing the X-Tiles program, the ideal HALP cut-off value was established, and the patients were separated into low and high HALP groups. Univariate and multivariate analysis were used to determine the relationship between HALP score and lymph node metastasis and recurrence of endometrial cancer.

Results
The optimal cut-off value of HALP score was established to be 22.2 using X-Tiles software, and the patients were separated into high HALP group (HALP score > 22.2, with 43 cases) and low HALP group (HALP score ≤ 22.2, 115 cases). Endometrial cancer patients’ HALP scores were strongly connected with differentiation, the degree of myometrial invasion, and lymph node metastasis (P < 0.05), although not with age, menopausal status, or stage (P > 0.05). Multivariate logistic regression analysis revealed that the HALP score (OR = 2.087) was the influencing factor for lymph node metastasis (P < 0.05). The ROC curve suggested that the AUC of HALP score in predicting lymph node metastasis was 0.871, which had high diagnostic value. When compared to patients without recurrence, HALP scores of patients with recurrence were considerably lower (P < 0.05). Multivariate logistic regression analysis showed that HALP score (OR = 2.216) was the influencing factor for the occurrence of lymph node metastasis (P < 0.05). The ROC curve suggested that the AUC of HALP score in predicting relapse was 0.855, with high diagnostic value.

Conclusion
The HALP score shows good predictive performance in predicting lymph node metastasis and recurrence of endometrial cancer, and has high clinical value, which helps in improving the accuracy and effectiveness of clinical diagnosis and prognosis research.
Rivaroxaban, a direct inhibitor of coagulation factor Xa, attenuates adverse cardiac remodeling in rats by regulating the PAR-2 and TGF-β1 signaling pathways
Authors: Zhang Qian , Zhang Zhongfan , Chen Weiwei , Zheng Haikuo , Si Daoyuan , Zhang Wenqi 
Published: September 2023

Background
Factor Xa (FXa) not only plays an active role in the coagulation cascade but also exerts non-hemostatic signaling through the protease-activated receptors (PARs). This study aimed to investigate whether the FXa inhibitor, Rivaroxaban (RIV), attenuates adverse cardiac remodeling in rats with myocardial infarction (MI) and to identify the underlying molecular mechanisms it uses.

Methods
An MI model was induced in eight-week-old, male Wistar rats, by permanent ligation of the left anterior descending coronary artery. MI rats were randomly assigned to receive RIV or protease-activated receptors 2-antagonist (PAR-2 antagonist, FSLLRY) treatment for four weeks. Histological staining, echocardiography and hemodynamics were used to assess the cardioprotective effects of RIV. Meanwhile, pharmacological approaches of agonist and inhibitor were used to observe the potential pathways in which RIV exerts antifibrotic effects in neonatal rat cardiac fibroblasts (CFs). In addition, real-time PCR and western blot analysis were performed to examine the associated signaling pathways.

Results
RIV presented favorable protection of left ventricular (LV) cardiac function in MI rats by significantly reducing myocardial infarct size, ameliorating myocardial pathological damage and improving left ventricular (LV) remodeling. Similar improvements in the PAR-2 antagonist FSLLRY and RIV groups suggested that RIV protects against cardiac dysfunction in MI rats by ameliorating PAR-2 activation. Furthermore, an in vitro model of fibrosis was then generated by applying angiotensin II (Ang II) to neonatal rat cardiac fibroblasts (CFs). Consistent with the findings of the animal experiments, RIV and FSLLRY inhibited the expression of fibrosis markers and suppressed the intracellular upregulation of transforming growth factor β1 (TGFβ1), as well as its downstream Smad2/3 phosphorylation effectors in Ang II-induced fibrosis, and PAR-2 agonist peptide (PAR-2 AP) reversed the inhibition effect of RIV.

Conclusions
Our findings demonstrate that RIV attenuates MI-induced cardiac remodeling and improves heart function, partly by inhibiting the activation of the PAR-2 and TGF-β1 signaling pathways.
The Impact of Roof Coating and Solar PV System in the Tropical Region of Ghana
Authors: Opare Wisdom , Adjardjah Winfred , Afonaa-Mensah Stephen , Addor John Awuah 
Published: September 2023

Adding PV module to roof has impacts on building`s electricity energy consumption. The aim of this paper is to assess the energy consumption performance of buildings by integrating solar Photovoltaic (PV) system into buildings with roof coating. An experiment was conducted to verify the efficient outcome of PV module using a building from the Anaji area of Takoradi in the Western region of Ghana. A framework energy model was proposed to analyse the integrated contribution of coating and PV performance using PVSOL. The temperature of the coated roof surfaces underneath the PV panels were significantly lower than that of the exposed roof in the daytime. The system integrated energy efficiency for flat and tilted overhead PV roofs are 63.35 % and 62.73 %, respectively. Using the mean absolute percentage error (MAPE) performance criterion, the monthly energy savings for coated roofs with solar PV is 28.86 kW or GH¢ 340.21; while the monthly energy savings for coated roofs without PV is 25.91 kW or GH¢ 303.00. Overall, the proposed integrated coated roof with PV outperforms the coated roof without PV. Validating the model, the mean relative errors (MRE) were all below 10%, while the accuracy of Power-Added Efficiency (PAE) were all beyond 95%. Thus, the proposed integrated roof coating and solar PV model for optimizing energy consumption is reliable.
Scientific production on quality and safety in obstetric care: bibliometric studytric / Produção Científica Sobre Qualidade e Segurança na Assistência Obstétrica estudo bibliométrico
Authors: Lucio Poliana Silva , Cabral Juliana Juliana da Rocha , Freire Daniela de Aquino , De Oliveira Regina Célia 
Published: September 2023

Objetivo: analisar a frequência de palavras correlacionando com o título e resumo da produção científica sobre a qualidade e segurança na assistência obstétrica à luz da Lei de Zipf (frequência de palavras). Método: trata-se de um estudo bibliométrico, que possibilita compreender os padrões de produtividade científica ao longo dos anos. realizaram-se buscas nas bases de dados LILACS, MEDLINE, Bdenf e SCOPUS (Elsivier) mediante utilização dos seguintes descritores oriundos do DeCS: obstetrícia/ obstetrics, segurança do paciente/ patient safety, qualidade dos serviços/ quality of health care; associou-se a esses termos o operador booleano AND. Resultados: após realizado o levantamento bibliométrico foram identificados 14 artigos relacionados que contemplaram à temática em estudo. Estes artigos estão publicados em 13 periódicos distintos. Conclusão: com base nos resultados apresentados, evidencia-se que, dentre os 14 artigos recrutados – desde 2014 a 2021, foram predominantes os estudos cuja abordagem relaciona-se intrinsecamente à temática qualidade e segurança na assistência obstétrica.
Polygenic Risk Score Added to Conventional Case Finding to Identify Undiagnosed Chronic Obstructive Pulmonary Disease
Authors: Zhang Jingzhou , Hobbs Brian D. , Silverman Edwin K. , Sparrow David , Ortega Victor E. , Xu Hanfei , Zhang Chengyue , Dupuis Josée , Walkey Allan J. , O’Connor George T. , Cho Michael H. , Moll Matthew 
Published: January 2025

ImportanceChronic obstructive pulmonary disease (COPD) is often undiagnosed. Although genetic risk plays a significant role in COPD susceptibility, its utility in guiding spirometry testing and identifying undiagnosed cases is unclear.ObjectiveTo determine whether a COPD polygenic risk score (PRS) enhances the identification of undiagnosed COPD beyond a case-finding questionnaire (eg, the Lung Function Questionnaire) using conventional risk factors and respiratory symptoms.Design, Setting, and ParticipantsThis cross-sectional analysis of participants 35 years or older who reported no history of physician-diagnosed COPD was conducted using data from 2 observational studies: the community-based Framingham Heart Study (FHS) and the COPD-enriched Genetic Epidemiology of COPD (COPDGene) study.ExposuresModified Lung Function Questionnaire (mLFQ) scores and COPD PRS.Main Outcomes and MeasuresThe primary outcome was spirometry-defined moderate to severe COPD (forced expiratory volume in the first second of expiration/forced vital capacity [FEV1/FVC] &amp;lt;0.7 and FEV1 [percent predicted] &amp;lt;80%). The performance of logistic models was assessed using the PRS, mLFQ score, and PRS plus mLFQ score for predicting spirometry-defined COPD.ResultsAmong 3385 FHS participants (median age, 52.0 years; 45.9% male) and 4095 COPDGene participants (median age, 56.8 years; 55.5% male) who reported no history of COPD, 160 (4.7%) FHS and 775 (18.9%) COPDGene participants had spirometry-defined COPD. Adding the PRS to the mLFQ score significantly improved the area under the curve from 0.78 to 0.84 (P &amp;lt; .001) in FHS, 0.69 to 0.72 (P = .04) in COPDGene non-Hispanic African American, and 0.75 to 0.78 (P &amp;lt; .001) in COPDGene non-Hispanic White participants. At a risk threshold for spirometry referral of 10%, the addition of the PRS to the mLFQ score correctly reclassified 13.8% (95% CI, 6.6%-21.0%) of COPD cases in FHS, but not in COPDGene.Conclusions and RelevanceA COPD PRS enhances the identification of undiagnosed COPD beyond a conventional case-finding approach in the general population. Further research is needed to assess its impact on COPD diagnosis and outcomes.
Combination of Baricitinib and Phototherapy in Adults With Active Vitiligo
Authors: Seneschal Julien , Guyon Mathilde , Merhi Ribal , Mazereeuw-Hautier Juliette , Andreu Nicolas , Cazenave Sarah , Ezzedine Khaled , Passeron Thierry , Boniface Katia 
Published: January 2025

ImportanceVitiligo is a chronic autoimmune disorder leading to skin depigmentation and reduced quality of life (QOL). Patients with extensive and very active disease are the most difficult to treat.ObjectiveTo assess the efficacy and adverse events of baricitinib combined with narrowband UV-B in adults with severe, active, nonsegmental vitiligo.Design, Setting, and ParticipantsThis academic, multicenter, double-blind, noncomparative randomized clinical trial was conducted at 4 dermatology departments between July 2021 and April 2023 and included adult patients with extensive and active nonsegmental vitiligo. The study was designed to evaluate the effect of baricitinib plus narrowband UV-B based solely on the results from this experimental group. The placebo group was used as a calibration group. Data were analyzed from August to November 2023.InterventionsParticipants were randomized 3:1 to baricitinib, 4 mg per day, or placebo for 36 weeks alone for the first 12 weeks and then in combination with narrowband UV-B twice a week from weeks 12 to 36.Main Outcomes and MeasuresThe primary outcome was mean percentage change in total Vitiligo Area Scoring Index (VASI) score from baseline to week 36 (baricitinib group). The prespecified aim of the study was to show that the reduction in the baricitinib plus narrowband UV-B was significantly greater than 42.9%, a repigmented surface threshold previously observed in patients treated with narrowband UV-B alone. Adverse events and secondary outcomes of change in disease activity and QOL were assessed. Post hoc analyses were additionally performed.ResultsOf 49 included patients, 35 (71%) were female, and the median (IQR) age was 49.9 (38.4-59.8) years. A total of 37 patients were randomized to the baricitinib group and 12 to the placebo group. The mean change in total VASI at week 36 was −44.8% (95% CI, −58.4% to −31.3%) for the baricitinib group and −9.2% (95% CI, −27.7% to 24.7%) for the placebo group. This was not significantly greater than the sufficient repigmented surface threshold of 42.9%. Post hoc analyses showed a significant difference at week 36 for total VASI score in the baricitinib plus narrowband UV-B group compared with placebo plus narrowband UV-B (−44.8% vs −9.2%, respectively; P = .02). There was a greater improvement in disease activity and QOL in the baricitinib group vs placebo group and no significant difference in the number of adverse events.Conclusions and RelevanceThis proof-of-concept randomized clinical trial confirmed the efficacy of baricitinib combined with narrowband UV-B in the treatment of patients with extensive and active vitiligo.Trial RegistrationClinicalTrials.gov Identifier: NCT04822584