bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implications of uremic cardiomyopathy for the practicing clinician: an educational review
Authors: Hiraiwa Hiroaki , Kasugai Daisuke , Okumura Takahiro , Murohara Toyoaki 
Published: May 2023

Abstract
Studies over recent years have redeveloped our understanding of uremic cardiomyopathy, defined as left ventricular hypertrophy, congestive heart failure, and associated cardiac hypertrophy plus other abnormalities that result from chronic kidney disease and are often the cause of death in affected patients. Definitions of uremic cardiomyopathy have conflicted and overlapped over the decades, complicating the body of published evidence, and making comparison difficult. New and continuing research into potential risk factors, including uremic toxins, anemia, hypervolemia, oxidative stress, inflammation, and insulin resistance, indicates the increasing interest in illuminating the pathways that lead to UC and thereby identifying potential targets for intervention. Indeed, our developing understanding of the mechanisms of UC has opened new frontiers in research, promising novel approaches to diagnosis, prognosis, treatment, and management. This educational review highlights advances in the field of uremic cardiomyopathy and how they may become applicable in practice by clinicians. Pathways to optimal treatment with current modalities (with hemodialysis and angiotensin-converting enzyme inhibitors) will be described, along with proposed steps to be taken in research to allow evidence-based integration of developing investigational therapies.
Camp Archaeology at the Site of National Remembrance in Łambinowice (Formerly Lamsdorf), Poland
Authors: Kobiałka Dawid , Pawleta Michał , Karski Kamil , Kostyrko Mikołaj , Lokś Adam , Rezler-Wasielewska Violetta , Stanek Piotr , Czerner Anna , Góra Elżbieta , Michalski Marek , Tomczak Sonia , Kowalczyk Zuzanna , Ważyński Szymon , Wroniecki Piotr 
Published: May 2023

AbstractSince June 2022, the Central Museum of Prisoners-of-War (Poland) has been carrying out a multidisciplinary research project entitled “Science for Society, Society for Science at the Site of National Remembrance in Łambinowice.” The aim of this article is to discuss the preliminary results of selected non-invasive and invasive archaeological and ethnographic research realized during the first months of the field activities. Additionally, they show the value of so-called community archaeology in which the participation of local inhabitants in field research is an important element of applied methodology.
Leisure, Employment, Community Participation, and Quality of Life in Primary Caregivers of Autistic Children: A Qualitative Study
Authors: Davy Gemma , Barbaro Josephine , Unwin Katy , Dissanayake Cheryl 
Published: May 2023

Abstract
Purpose
In prioritising the needs of their autistic children, parents often modify their own participation across leisure, social, and workforce activities. Few studies have examined the impact these modifications have on caregiver quality of life (QoL). The aim in the current study was to examine how parenting their autistic child/ren impacts parent’s participation and QoL.

Methods
Twenty primary caregivers (29–48 years, all female) of autistic children (7–11 years) were interviewed online about their participation in leisure, community, and employment activities including the impact of COVID-19.

Results
Five themes with underlying subthemes were identified using reflexive thematic analysis. The themes were: (1) Reflecting on the important things in life, (2) Getting access to everything needed, (3) Barriers to participation in meaningful activities, (4) Facilitators of participation in meaningful activities, and (5) Participation through the COVID-19 pandemic.

Conclusion
The findings highlight the importance of regular participation in meaningful activities for parents of autistic children and the support needed by them, particularly single parents, to achieve balance between meeting caring responsibilities and their own participation needs.
Dual Identification: Trajectories to English Proficiency for English Learners with Autism Spectrum Disorder
Authors: Castellón Fernanda A. , Sturm Alexandra , Kasari Connie 
Published: May 2023

Abstract
Background
There are an increasing number of English Learners (EL) served in schools, including children with Autism Spectrum Disorder (ASD). However, little is known about students who receive school-based services as EL and under autism eligibility.

Purpose & Methods
The present study aimed to examine the sociodemographic characteristics, time to English Language Proficient status by survival analysis, and predictors of English fluency utilizing a logistic regression for dually identified EL and autism eligible students in a large urban school district during the 2011–2019 academic school years.

Results
Overall, dually identified students (N = 849) educated in segregated settings (N = 372) became English proficient at lower rates and at older ages than students included in general education (N = 477).

Conclusion
Students placed in segregated special education classrooms were significantly less likely to achieve English Language Proficient classification. The present study begins to illustrate the time to English proficiency of dually identified students and the potential impact it has on their educational opportunities.
“A sociality of pure egoists”: Husserl’s critique of liberalism
Authors: Miettinen Timo 
Published: May 2023

AbstractAccording to Husserl’s self-description, his phenomenological project was “completely apolitical.” Husserl’s phenomenology did not provide a political philosophy in the classical sense, a normative description of a functioning social order and its respective institutional structures. Nor did Husserl have much to say about the day-to-day politics of his time. Yet his reflections on community and culture were not completely without political implications. This article deals with an often-neglected strand of Husserl’s philosophy, namely his critique of liberalism. In this article, liberalism is understood in the manner of Leo Strauss, as a tradition of individualist philosophy emerging from Hobbes’s political thought. As the article shows, Husserl followed many of his contemporaries in criticizing Hobbes’s abstract individualism, which could provide only a preventative function for political institutions. More importantly, Husserl’s engagement with Hobbes can be understood as a kind of ethical counterpart to his analysis of Galileo in the Crisis, as a critique of formal apriorism in the political domain. What Galileo did for physical nature with his “garb of ideas,” Hobbes did for human nature, reducing human sociality to interactions between atomistic individuals. In doing so, Hobbes ended up presenting a “mathematics of sociality” in an empirical garb. Going against the liberal view of the human person, Husserl presented his theory of social ethics founded on an original co-existence of subjects and a theory of human renewal.
Multiresolution analysis for COVID-19 diagnosis from chest CT images: wavelet vs. contourlet transforms
Authors: Abdel-Hamid Lamiaa 
Published: May 2023

AbstractChest computer tomography (CT) provides a readily available and efficient tool for COVID-19 diagnosis. Wavelet and contourlet transforms have the advantages of being localized in both space and time. In addition, multiresolution analysis allows for the separation of relevant image information in the different subbands. In the present study, transform-based features were investigated for COVID-19 classification using chest CT images. Several textural and statistical features were computed from the approximation and detail subbands in order to fully capture disease symptoms in the chest CT images. Initially, multiresolution analysis was performed considering three different wavelet and contourlet levels to determine the transform and decomposition level most suitable for feature extraction. Analysis showed that contourlet features computed from the first decomposition level (L1) led to the most reliable COVID-19 classification results. The complete feature vector was computed in less than 25 ms for a single image having of resolution 256 × 256 pixels. Next, particle swarm optimization (PSO) was implemented to find the best set of L1-Contourlet features for enhanced performance. Accuracy, sensitivity, specificity, precision, and F-score of a 100% were achieved by the reduced feature set using the support vector machine (SVM) classifier. The presented contourlet-based COVID-19 detection method was also shown to outperform several state-of-the-art deep learning approaches from literature. The present study demonstrates the reliability of transform-based features for COVID-19 detection with the advantage of reduced computational complexity. Transform-based features are thus suitable for integration within real-time automatic screening systems used for the initial screening of COVID-19.
On the Role of Signs in Epicurus’ Legal Theory
Authors: Connelly Stephen 
Published: May 2023

AbstractEpicurus holds, inKey Doctrine31, that what is just according to nature is asúmbolonor sign of the interest there is in neither harming one another nor being harmed. Certain readings of this maxim equivocate this legal sign with other signs found in nature, thereby failing to give sufficient weight to the role of reciprocity in its production. Other readings simply import a legal sense from outside of Epicurean doctrine, thereby failing to explain what makes Epicureansúmbolalegal. A final set of readings attempt to find a legal rule as a kind of innate concept or Kantian ‘scheme’. This article identifies new sources for understandingsúmbolon, drawn principally but not exclusively from Aristotle’sEudemian Ethics. This article offers an original argument that Epicurus adopts Aristotle’s’ image of the tally stick (symbolon) as a meeting of often divergent interests which constitutes something new and particularly valuable to the Epicurean: friendship. A theoretical argument is also advanced to support this reading which claims that one person’s reflection on a ‘divine image’ of the end (telos) is insufficient to constitute asúmbolon; rather real (as opposed to abstract or ideal) individual interests are filtered via the mechanism of the tally, that is via the meeting of two given individuals who together generate a sign (symbolon) of reciprocal interest in neither harming nor being harmed.
HEX: a safe research framework for hybrid EMT X-ray navigation
Authors: Krumb Henry J. , Dorweiler Bernhard , Mukhopadhyay Anirban 
Published: May 2023

Abstract
Purpose
Navigating with continuous X-ray provides visual guidance, but exposes both surgeon and patient to ionizing radiation, which is associated with serious health risks. Interleaving fluoro snapshots with electromagnetic tracking (EMT) potentially minimizes radiation.

Methods
We propose hybrid EMT + X-ray (HEX), a research framework for navigation with an emphasis on safe experimentation. HEX is based on several hardware and software components that are orchestrated to allow for safe and efficient data acquisition.

Results
In our study, hybrid navigation reduces radiation by $$71\%$$

71
%

with cubic, and by $$40\%$$

40
%

with linear error compensation while achieving submillimeter accuracy. Training points for compensation can be reduced by half while keeping a similar accuracy–radiation trade-off.

Conclusion
The HEX framework allows to safely and efficiently evaluate the hybrid navigation approach in simulated procedures. Complementing intraoperative X-ray with EMT significantly reduces radiation in the OR, increasing the safety of patients and surgeons.
Value of fat-suppressed T2-weighted imaging for predicting short-term pain relief after sclerotherapy for venous malformations in the extremities
Authors: Nagata Shuji , Tanaka Norimitsu , Kuhara Asako , Kugiyama Tomoko , Tanoue Shuichi , Koganemaru Masamichi , Uchiyama Yusuke , Fujimoto Kiminori , Abe Toshi 
Published: May 2023

Abstract
Purpose
This study aimed to evaluate the value of fat-suppressed T2-weighted imaging (FS-T2WI) for predicting short-term pain relief after polidocanol sclerotherapy for painful venous malformations (VMs) in the extremities.

Materials and methods
This retrospective study included patients with painful VMs in the extremities between October 2014 and September 2021, had their first sclerotherapy without history of surgical therapy, and underwent magnetic resonance imaging before sclerotherapy. Pain relief was assessed 2 months after 3% polidocanol sclerotherapy and was categorized as follows: progression, no change, partial relief, or free of pain. The associations between pain relief and imaging features on FS-T2WI were analyzed.

Results
The study included 51 patients. The no change, partial relief, and free of pain groups included 6 (11.8%), 25 (49.0%), and 20 (39.2%) patients, respectively. No patient experienced progressive pain. The lesion diameter was ≤ 50 mm in 13 (65.0%) patients in the free of pain group, whereas it was > 50 mm in all patients in the no change group (p = 0.019). The lesions showed well-defined margin in 15 (75.0%) patients in the free of pain group, whereas they showed ill-defined margin in 5 (83.3%) patients in the no change group (p = 0.034). The most common morphological type was cavitary in the free of pain group (14 [70.0%] patients), whereas there was no patient with cavitary type lesion in the no change group (p = 0.003). Drainage vein was demonstrated in 6 (100%), 22 (88.0%), and 11 (55.0%) patients in the no change, partial relief, and free of pain group, respectively (p = 0.011).

Conclusion
A lesion size of 50 mm or less, a well-defined margin, a cavitary type, and no drainage vein on FS-T2WI were significant features for predicting short-term pain relief after polidocanol sclerotherapy for painful VMs in the extremities.
Automated Determination of Grain Features for Wire Arc Additive Manufacturing
Authors: Karimi J. , Bohlen A. , Kamboj N. , Seefeld T. 
Published: May 2023

AbstractThe morphology and size of the grains of the additively manufactured (AM) parts affect the mechanical properties and performance. The present research aimed to analyze the microstructure of AM parts, particularly the grain features, using image processing techniques. AMed aluminum components were fabricated using wire arc additive manufacturing based on cold metal transfer. The AA 5183 tensile samples fabricated using WAAM-CMT showed ductile behavior and the presence of the Lüder bands. Metallographic sections were prepared, and fine equiaxed grain was observed. An automatic image evaluation program for determining the specified grain features was developed. The grain features, including size, area, perimeter, and sphericity, were quantified, and the obtained results were verified, indicating a satisfactory agreement with those obtained from manual measurement. The output of the image processing technique clearly proved that the MATLAB program, as an affordable and swift approach (~ 4.8 s), can be used successfully to determine the microstructural properties. The image processing techniques could significantly improve the reliability and analysis of the microstructure, which would lead to the possibility of characterizing the microstructure in a broader range and having more details, and saving time and cost.
Predictive value of the deltoid tuberosity index for assessing the risk of screw cut-out
Authors: Da Silva Tomas , Ehrhard David-Benjamin , Chuchuy Theo Manuel , Knop Christian , Merkle Tobias 
Published: May 2023

Abstract
Background
Reconstruction of the proximal humerus with a locking plate is often the first surgical approach for proximal humerus fractures. Screw cut-out is a common complication and is relevant in osteoporotic bone of older adults. The Deltoid Tuberosity Index (DTI) is an indirect measure for assessing local bone quality and failure rate before surgery, providing important information for surgical planning. This was the first independent, large-sample retrospective analysis of the correlation between local bone density, indirectly measured through the DTI, and screw cut-out.

Methods
In total, 306 cases of proximal humerus fractures treated with the PHILOS plate (DePuy Synthes, Oberdorf, Switzerland) were retrospectively analyzed. The DTI was measured on anteroposterior x‑rays. The primary endpoint was screw cut-out defined as the intra-articular position of at least one screw associated with a reduction loss after surgery.

Results
The mean clinical follow-up was 935 days. The DTI varied from 1.10 to 2.28 (average: 1.45). Screw cut-out occurred on average in 8% of the cases and was positively correlated with a DTI of ≤ 1.44 (p = 0.003). However, the rate of cut-out and correlation with DTI varied widely according to age group: for ages 65–80 years, a DTI of ≤ 1.44 increased the cut-out rate from 0% to 17% (p = 0.02); in younger ages (< 65 years) the DTI did not correlate with cut-out and in the oldest group (> 80 years) cut-out rates were high (17–20%) independently of the DTI.

Conclusion
We confirm the correlation between a DTI of ≤ 1.44 and screw cut-out. High-risk groups for screw cut-out are patients over 65 years with a DTI of ≤ 1.44 or any patient older than 80 years. Applying the DTI in the age group of 65–80 years offers relevant information for surgical planning in the trauma setting via a fast, cheap, and easy-to-use tool.
Level of Evidence: Level 3, Retrospective Cohort Study.
Metastatic differentiated thyroid cancer: worst prognosis in patients with metachronous metastases
Authors: González-Clavijo Angélica María , Cuellar Andrés A. , Triana-Urrego Jenny , Barrero Jorge A. , Fierro-Maya Luis Felipe 
Published: May 2023

Abstract
Purpose
To describe the overall survival and progression-free survival in patients diagnosed with differentiated thyroid carcinoma with synchronous and metachronous metastatic involvement.

Materials and methods
A retrospective cohort study was conducted with 101 patients with differentiated thyroid cancer (DTC) who had metastatic involvement at diagnosis or during follow-up, who were treated at the National Cancer Institute between January 1, 2010 and December 31 of 2015.

Results
81 patients (80.2%) were women and the mean age at diagnosis was 49 years (12–80). Synchronous metastases were detected in 54.5% of patients and metachronous metastasis was diagnosed in 45.5% of patients, in whom the mean time between initial diagnosis and the finding of distant metastases was 5 years. Pulmonary involvement occurred in almost all patients, with 131I uptake in 58% of synchronous metastases and in 21% of metachronous. There were 10 events in the patients with 131I-avid metastases with a median time to progression that was not reached, and there were 23 events in patients with 131I-refractory metastases with a median time to progression of 96 months; The median time to progression was significantly longer in patients with synchronous metastases compared to those with metachronous metastases (Not reached vs 95 months, P = 0.017) The 5-year overall survival rate was 95% to the entire cohort.

Conclusions
The present study contributes to the expansion of the knowledge about this clinical course of DTC with the finding of a worst prognosis in patients with metachronous metastases.
Investigating the Synergistic Potential of Low-Dose HDAC3 Inhibition and Radiotherapy in Alzheimer’s Disease Models
Authors: Ricciardi Natalie R. , Modarresi Farzaneh , Lohse Ines , Andrade Nadja S. , Newman Ian R. , Brown Jonathan M. , Borja Caroline , Marples Brian , Wahlestedt Claes R. , Volmar Claude-Henry 
Published: May 2023

AbstractWe have previously shown that histone deacetylase (HDAC) inhibition and cranial radiotherapy (RT) independently improve molecular and behavioral Alzheimer’s disease (AD)-like phenotypes. In the present study, we investigate the synergistic potential of using both RT and HDACi as a low-dose combination therapy (LDCT) to maximize disease modification (reduce neuroinflammation and amyloidogenic APP processing, increase neurotrophic gene expression) while minimizing the potential for treatment-associated side effects.LDCT consisted of daily administration of the HDAC3 inhibitor RGFP966 and/or bi-weekly cranial x-irradiation. Amyloid-beta precursor protein (APP) processing and innate immune response to LDCT were assessed in vitro and in vivo using human and murine cell models and 3xTg-AD mice. After 2 months of LDCT in mice, behavioral analyses as well as expression and modification of key AD-related targets (Aβ, tau, Csf1r, Bdnf, etc.) were assessed in the hippocampus (HIP) and prefrontal cortex (PFC).LDCT induced a tolerant, anti-inflammatory innate immune response in microglia and increased non-amyloidogenic APP processing in vitro. Both RT and LDCT improved the rate of learning and spatial memory in the Barnes maze test. LDCT induced a unique anti-AD HIP gene expression profile that included upregulation of neurotrophic genes and downregulation of inflammation-related genes. RT lowered HIP Aβ42/40 ratio and Bace1 protein, while LDCT lowered PFC p-tau181 and HIP Bace1 levels.Our study supports the rationale for combining complementary therapeutic approaches at low doses to target multifactorial AD pathology synergistically. Namely, LDCT with RGFP966 and cranial RT shows disease-modifying potential against a wide range of AD-related hallmarks.
Compacted bentonite hydro-mechanical modelling when interaggregate porosity tends to zero
Authors: Navarro Vicente , Asensio Laura , Cabrera Virginia , De la Morena Gema , Yustres Ángel , Torres-Serra Joel 
Published: May 2023

AbstractA formulation is proposed for reproducing the hydro-mechanical behaviour of compacted bentonites as interaggregate porosity becomes negligible. In that case, the model assumes the bentonite deformability to be controlled only by the microstructural modelling level in a double porosity approach. Hence, the bulk stiffness of the system is defined by the relationship between the microstructural void ratio and the thermodynamic swelling pressure, requiring no additional parameters to simulate the overall behaviour. An experimental study has been conducted to check the conceptual consistency of the formulation, with favourable results. The quantitative potential of the model has also been satisfactorily verified by numerical simulation of the tests carried out in this study. A displacement-based finite-element model developed for double porosity systems has been modified to run the simulations. The proposed formulation has been implemented using a simple strategy that can be easily replicated for similar numerical models. Both the simulation capabilities and the computational cost efficiency of the proposed formulation confirm its practical interest.
Derivations and loops of some evolution algebras
Authors: Cabrera Casado Yolanda , Cadavid Paula , Reis Tiago 
Published: May 2023

AbstractIn this work we study the space of derivations of non-degenerate evolution algebras. We improve some results obtained recently in the literature and, as a consequence, we advance in the description of the derivations for n-dimensional Volterra evolution algebras. In addition, we introduce the notion of loop of an evolution algebra and we analyze under which conditions the set of loops is invariant under change of basis.