bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms of gas transfer impairment utilizing nitric oxide following severe COVID‐19 pneumonitis
Authors: Seccombe Leigh M. , Heath David , Farah Claude S. , Di Michiel James R. , Veitch Elizabeth M. , Peters Matthew J. 
Published: April 2023

AbstractReduced carbon monoxide diffusing capacity (DLCO) is common after recovery from severe COVID‐19 pneumonitis. The extent to which this relates to alveolar membrane dysfunction as opposed to vascular injury is uncertain. Simultaneous measurement of nitric oxide diffusing capacity (DLNO) and DLCO can partition gas diffusion into its two components: alveolar–capillary membrane conductance (DmCO) and capillary blood volume (VC). We sought to evaluate DmCO and VC in the early and later recovery periods after severe COVID‐19. Patients attended for post‐COVID‐19 clinical review and lung function testing including DLNO/DLCO. Repeat testing occurred when indicated and comparisons made using t‐tests. Forty‐nine (eight female) subjects (mean ± SD age: 58 ± 13, BMI: 34 ± 8) who had severe COVID‐19 pneumonitis, WHO severity classification of 6 ± 1, and prolonged (21 ± 22 days) hospital stay, were assessed 2 months (61 ± 35 days) post discharge. DLCOadj (z‐score −1.70 ± 1.49, 25/49 < lower limit of normal [LLN]) and total lung capacity (z‐score −1.71 ± 1.30) were both reduced. DmCO and VC and were reduced to a similar extent (z‐score −1.19 ± 1.05 and −1.41 ± 1.20, p = 0.4). Seventeen (one female) patients returned for repeat testing 4 months (122 ± 61 days) post discharge. In this subgroup with more impaired lung function, DLCOadj improved but remained below LLN (z‐score −3.15 ± 0.83 vs. −2.39 ± 0.86, p = 0.01), 5/17 improved to >LNN. DmCO improved (z‐score −2.05 ± 0.89 vs. −1.41 ± 0.78, p = 0.01) but VC was unchanged (z‐score −2.51 ± 0.55 vs. −2.29 ± 0.59, p = 0.16). Alveolar membrane conductance is abnormal in the earlier recovery phase following severe COVID‐19 but significantly improves. In contrast, reduced VC persists. These data raise the possibility that persisting effects of acute vascular injury may contribute to gas diffusion impairment long after severe COVID‐19 pneumonitis.
The End of the Print Era
Authors: Askey Dale 
Published: April 2023

Abstract
By 2040, libraries will transit from viewing print books as the standard form for preservation to using digital editions as the copy of record. Libraries will pulp most of their print collections and retain mostly small special collections. Climate change and the resulting political and social instability will drive this transition, but there are potential gains for readers and research if we choose as libraries to pursue them.
Leptin ameliorates Aβ1-42-induced Alzheimer’s disease by suppressing inflammation via activating p-Akt signaling pathway
Authors: Lu Lin , Fu Zijuan , Wu Bing , Zhang Dongsen , Wang Ying 
Published: April 2023

Abstract

Background
Alzheimer’s disease (AD) is characterized by progressive neuronal loss, cognitive disorder, and memory decline. Leptin has been reported to have a neuroprotective effect on neurodegenerative diseases.

Objective
Our aim was to investigate whether intraperitoneal injection of leptin has a neuroprotective effect and to explore its underlying mechanisms in the AD mouse model.

Methods
Aβ1-42 was injected into male C57BL/6J mice to construct an AD mouse model, and leptin was injected intraperitoneally to cure AD. The Morris water maze test was used to investigate spatial learning ability. Neuronal loss was tested by tyrosine hydroxylase expression in the hippocampus, and terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling assay was applied to detect neuronal apoptosis. Pro-inflammatory cytokine levels were monitored by RT-PCR and western blotting was selected to explore which signaling pathway leptin acted on.

Results
Leptin ameliorated spatial learning impairment, restored neuronal loss and apoptosis, and inhibited pro-inflammatory cytokine expression by activating the p-Akt signaling pathway in Aβ1-42-induced AD mice.

Conclusion
Leptin ameliorates Aβ1-42-induced AD by suppressing inflammation via activating the p-Akt signaling pathway.
Медійні можливості коміксів: сучасні інструменти формування та представлення організаційної культури
Authors: Hudoshnyk Oksana V. , Krupskyi Oleksandr P. 
Published: April 2023

Мета роботи: Сучасний розвиток масової культури характеризується зростанням ринку графічних наративів, стрімким збільшенням сегмента цифрових коміксів, активним використанням коміксу як інструменту комунікації в різних галузях і дисциплінарних напрямах. Мета дослідження: визначити медійні можливості коміксу в представленні освітньо-навчального, кроскультурного та проблемно-етичного контенту сучасної організаційної культури.
Дизайн / Метод / Підхід дослідження: Оглядовий характер статті передбачає залучення традиційних загальнонаукових методів (опис, порівняння, абстрагування та конкретизація). Міждисциплінарність дослідження актуалізувала компаративний метод у представленні крос-культурних особливостей організаційних/офісних/корпоративних коміксів.
Результати дослідження: Вплив візуальної масової культури та поширення міждисциплінарних інструментів дослідження уможливили в межах заявленої проблематики аналіз трьох напрямів: адаптивні та аудиторноспрямовані коміксові техніки популяризували їх використання з навчальною та освітньою метою; можливість зіставлення типології світових коміксів з кроскультурними глобальними дослідженнями (ми спиралися на методику та результати проєкту GLOBE (Global Leadership and Organizational Behavior Effectiveness); можливості коміксу відтворювати, підтримувати та поширювати традицію певної організаційної культури.
Теоретична цінність дослідження: Робота розширила: (1) можливості різновекторного підходу до коміксової культури з метою уточнення міждисциплінарної методики; (2) уявлення щодо формування та підтримки автентичної організаційної культури за допомогою коміксових технік; (3) можливості використання графічних наративів в процесі навчально-освітньої та професійної комунікації.
Практична цінність дослідження: Можливості використання коміксу в сучасній організаційній культурі на рівні самопрезентації, навчання та підтримки традицій.
Оригінальність/цінність дослідження: Презентовано різновекторний аналіз впливу масової культури (коміксової як її частини) на представлення повсякдення сучасних бізнес-процесів.
Обмеження дослідження / Майбутні дослідження: Аналіз бізнес-процесів мовою графічної культури вимагає валідних методів. Подальші дослідження потребують більшої статистичної вибірки та вдосконалення міждисциплінарних методик.
IMPLEMENTATION TRANSFER LEARNING CONVOLUTIONAL NEURAL NETWORK FOR POTHOLE DETECTION ON DRONE VIDEO
Authors: Muhaemen Miftahul , Mohammad Reza Faisal  , Dodon Turianto Nugrahadi  , Andi Farmadi  , Rudy Herteno  
Published: April 2023

Pothole is one of the problems that can cause harm to a person or a lot of people and can even cost lives. So a lot of research has been done to detect potholes, especially image-based. This research uses Unmanned Aerial Vehicle (UAV) to get aerial video dataset and train Convolutional Neural Network (CNN) with the dataset. However, instead of doing learning from the beginning, transfer learning can be used to train CNN to recognize the object of a pothole and measure the value of its performance and what the optimal frame rate is. Then the results of this study indicate that the CNN model, ssd_resnet_50_fpn_coco gets an average performance value of 48.90 mAP. And the optimal frame rate with the average highest performance value at a frame rate of 30FPS with a value of 49.43 mAP, followed by 1FPS with a value of 48.36 mAP .
Keywords: Performance, Transfer Learning, Convolutional Neural Network, Pothole Detection, Aerial Video.
IMPLEMENTATION OF RSA ENCRYPTION ALGORITHM ON INSTANT MESSAGING APPLICATION
Authors: Sukma Wijaya Ardiansyah , Dodon T. Nugrahadi  , Muhammad Itqan Mazdadi  , Andi Farmadi  , Ahmad Rusadi  
Published: April 2023

At this time the use of instant messaging applications is increasingly used compared to the use of SMS or other media because of its use which is more practical and faster. From the other side, the message information sent certainly requires confidentiality so that the message is not spread and known by others. For this reason mechanisms are needed, one of which is encryption to maintain message security. This research will implement the RSA (Rivest Shamir Adleman) encryption algorithm in the instant messaging application. This study uses a key length scenario of RSA 1024, 2048, 4096, and 6144 bits and a message length of 125, 250, 500, and 1000 characters implemented on 3 different devices. The results of testing on time and speed are the shorter the key used, the process will be shorter and faster.
Keywords : RSA, Processing Time, Processing Speed
KARAKTERISTIS DAN LAJU PEMBAKARAN BRIKET ARANG TEMPURUNG KELAPA DENGAN PENAMBAHAN AROMATERAPI AKAR WANGI (Vetiveria zizanoides) DAN GAHARU (Aquilaria malaccensis)
Authors: Mahdie Muhammad Faisal , Rahmadi Adi , Indrayatie Eko Rini , Sari Noor Mirad , Arsya Hanifa 
Published: April 2023

Limbah dari buah kelapa adalah tempurung kelapa yang umumnya digunakan sebagai bahan bakar sehari – hari. Serbuk akar wangi dan limbah serbuk kayu gaharu mengandung resin yang selama ini belum dimanfaatkan secara maksimal menjadi solusi dalam penyediaan bahan aromaterapi karena mengandung aroma yang menenangkan dan menghilangkan stress. Tujuan dari penelitian adalah (1) Menganalisis Uji Karakteristik briket arang aromaterapi tempurung kelapa dengan penambahan serbuk akar wangi dan serbuk kayu gaharu yang meliputi kerapatan, uji kadar air, kadar abu, kadar zat terbang, kadar karbon terikat, nilai kalor dan laju pembakaran (2) Mengetahui perlakuan terbaik dari briket arang aromaterapi tempurung kelapa dengan penambahan serbuk akar wangi dan limbah serbuk kayu gaharu. Pengujian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 6 perlakuan dan 3 kali ulangan, jadi jumlah seluruh sampel sebanyak 18 buah. Kadar air tertinggi sebesar 8,55% terdapat pada perlakuan E dan terendah terdapat pada perlakuan C yaitu 4,05%, kadar abu briket aromaterapi bervariasi yaitu nilai terendah 6,19% pada perlakuan E dan tertinggi 11,46% pada perlakuan A. Nilai rata-rata zat terbang tertinggi 60,29% terdapat pada perlakuan E dan kadar zat terbang terendah 42,83% terdapat pada perlakuan F. Kadar karbon terikat tertinggi terdapat pada perlakuan F yaitu 43,66% dan rata-rata terendah terdapat pada perlakuan E yaitu 24,97%. Nilai kalor bervariasi antara 4885,21 kal/gr - 5516,24 kal/gr, kadar karbon terendah terdapat pada perlakuan E dan perlakuan F memiliki nilai kalor tertinggi. Rata-rata kerapatan briket arang aromaterapi tertinggi sebesar 0,8546 gr/cm3 terdapat pada perlakuan F dan perlakuan E memiliki rata-rata kerapatan terendah yaitu 0,5740 gr/cm3 . Laju pembakaran terendah terdapat pada perlakuan D yaitu 0,39 gr/menit dan tertinggi terdapat pada perlakuan E yaitu 0,63 gr/menit. Kadar air terbaik terdapat pada perlakuan C yaitu 4,05% (SNI < 8%), kadar abu terbaik terdapat pada perlakuan E yaitu 6,19% (SNI < 8%), semua perlakuan untuk zat terbang belum memenuhi standar (SNI < 15%), pengujian karbon terikat dan kerapatan tidak mensyaratkan standar SNI, nilai karbon terbaik pada perlakuan F yaitu 5516,24 kal/gr (SNI > 5000 kal/gr).
KERAGAMAN JENIS SATWA BURUNG PADA VEGETASI MANGROVE DI DESA TAAR KECAMATAN DULLAH SELATAN KOTA TUAL
Authors: Audryvca Sapulette Sophia Sylvana , Pattinasarany Cornelis Katje , Soselisa Fanny 
Published: April 2023

Desa Taar terletak di kecamatan Dullah Selatan Kota Tual, yang memiliki daya tarik akan kawasan mangrove yang cukup luas sehingga merupakan habitat yang baik bagi beberapa jenis burung. Desa Taar memiliki beberapa jenis burung yang ditemukan antara lain: Cikukua seram (Philemon moluccensis), Gajahan Timur (Numenius madagascariensis), Kowak Malam Merah (Nycticorax caledonicus), Nuri Maluku (Eos bornea), Pergam Tarut (Ducula concina) dan beberapa jenis lainnya. Penelitian ini bertujuan untuk mengetahui keragaman jenis satwa burung pada vegetasi mangrove dan untuk mengetahui pengaruh kerapatan vegetasi mangrove terhadap keragaman jenis satwa burung di desa Taar. Metode pengamatan satwa burung yang digunakan adalah metode Line Transek dan pengamatan vegetasi dilakukan berdasarkan metode Analisis Garis Berpetak pada jalur – jalur pengamatan yang sudah ditentukan. Keragaman satwa burung yang ditemukan di desa Taar pada jalur 1 sampai dengan jalur 10 sebanyak 14 jenis. Pada jalur 1 nilai H’ = 2,02 dengan jumlah jenis 9 satwa burung; jalur 2 H’ = 2,31 jumlah jenis 11 satwa burung; jalur 3 H’ = 2,07 jumlah jenis 10 satwa burung; jalur 4 H’ = 1,83 jumlah jenis 8 satwa burung; jalur 5 H’ = 2,13 jumlah jenis 10 satwa burung; jalur 6 H’ = 2,14 jumlah jenis 11 satwa burung; jalur 7 H’ = 2,20 jumlah jenis 12 satwa burung; jalur 8 H’ = 2,27 jumlah jenis 11 satwa burung; jalur 9 H’ = 2,36 jumlah jenis 12 satwa burung; jalur 10 H’ = 2,25 jumlah jenis 10 satwa burung. hasil analisa regresi menunjukkan tidak ada pengaruh nyata antara variabel kerapatan terhadap keragaman jenis satwa burung.
Pengaruh Iklim Organisasi, Motivasi Kerja dan Keadilan Organisasi Terhadap Organizational Citizenship Behaviour Pada Karyawan Perusahaan Umum di Jakarta dan Banten
Authors: Yulfiantie Hartono Syahla , Parimita Widya , Wahyu Handaru Agung 
Published: April 2023

The purpose of the study was to find out whether the organization's climate, work motivation, and organizational fairness had an effect on organizational citizenship behavior. This study took a sample of 111 employees of Perum Bulog Kanwil DKI Jakarta and Banten. This study used descriptive and multiple linear regression analysis. The results of this study indicate that organizational climate has a positive and significant effect on organizational citizenship behavior, work motivation has a positive and significant effect on organizational citizenship behavior and organizational justice has a positive and significant impact organizational citizenship behavior. Simultaneously organizational climate, work motivation and organizational justice has an impact on organizational citizenship behavior.

Tujuan penelitian ini adalah untuk mengetahui apakah iklim organisasi, motivasi kerja dan keadilan organisasi berpengaruh terhadap organizational citizenship behaviour. Penelitian ini mengambil sampel sebanyak 111 karyawan Perum Bulog Kanwil DKI Jakarta dan Banten Penelitian ini menggunakan analisis deskriptif dan analisis regresi berganda. Hasil penelitian ini menunjukan bahwa iklim organisasi memiliki pengaruh positif dan signifikan terhadap organizational citizenship behavior, motivasi kerja memiliki pengaruh positif dan signifikan terhadap organizational citizenship behavior, dan keadilan organisasi memiliki pengaruh positif dan signifikan terhadap organizational citizenship behavior. Secara simultan, iklim organisasi, motivasi kerja, dan keadilan organisasi berpengaruh secara signifikan terhadap organizational citizenship behavior.
Pengaruh Perceived Value dan Promotion terhadap Revisit Intention dengan Kepuasan sebagai Intervening
Authors: Anggraeni Rina , Rizan Mohamad , Basrah Saidani  
Published: April 2023

This study aims to determine the effect of perceived value and promotion on revisit intention with satisfaction as an intervention. Data was obtained by using a survey method with purposive sampling on a liktert scale to 220 respondents on visitors of Dunia Fantasi. The data analysis method used in this research is Structural Equation Modeling (SEM) using LISREL software version 8.8. The results show that there is a significant positive effect of perceived value on satisfaction, there is a significant positive effect of promotion on satisfaction, there is a significant positive effect of perceived value on revisit intention, there is a significant positive effect of promotion on revisit intention, there is a significant positive effect of satisfaction on revisit intention, there is a significant positive effect of satisfaction on revisit intention. There is a significant effect of perceived value on revisit intention through satisfaction, and there is a significant effect of promotion on revisit intention through satisfaction.

Penelitian ini bertujuan untuk mengetahui pengaruh perceived value dan promotion terhadap revisit intention dengan satisfaction sebagai intervening. Data diperoleh dengan menggunakan metode survei dengan purposive sampling secara skala liktert kepada 220 responden pengujung Dunia Fantasi. Metode analisis data yang digunakan dalam penelitian ini adalah Structural Equation Modeling (SEM) menggunakan Software LISREL versi 8.8. Hasil penelitian menunjukkan bahwa ada pengaruh positif signifikan perceived value terhadap satisfaction, terdapat pengaruh positif signifikan promotion terhadap satisfaction, terdapat pengaruh positif signifikan perceived value terhadap revisit intention, terdapat pengaruh positif signifikan promotion terhadap revisit intention, terdapat pengaruh positif signifikan satisfaction terhadap revisit intention, terdapat pengaruh signifikan perceived value terhadap revisit intention melalui satisfaction, dan terdapat pengaruh signifikan promotion terhadap revisit intention melalui satisfaction.
Excess Injury Mortality in Washington State During the 2021 Heat Wave
Authors: Casey Joan A. , Parks Robbie M. , Bruckner Tim A. , Gemmill Alison , Catalano Ralph 
Published: April 2023

Objectives. To determine whether the 2021 Pacific Northwest heat wave resulted in excess injury (both unintentional and intentional) deaths. Methods. With US death certificate data from December 29, 2013, to July 31, 2021, we generated weekly counts of injury deaths in Washington State and the rest of the country. We used time-series methods to identify excess injury deaths that may have occurred during and following the anomalously warm temperature period based on those expected from history and from simultaneous deaths in the remainder of the United States. Results. Beginning the week including June 25, 2021 (heat wave initiation), 3 weeks exceeded the expected count of injury deaths in Washington State, with an estimated total of 159 excess injury deaths (95% detection interval = 122, 195) during the 3-week period. Conclusions. The 2021 Pacific Northwest heat wave was associated with an increase in injury deaths. Public Health Implications. Under global warming scenarios, heat waves of this magnitude will become much more common. Adaptation and planning efforts are needed to protect residents of the historically temperate Pacific Northwest for a range of health outcomes. (Am J Public Health. 2023;113(6):657–660. https://doi.org/10.2105/AJPH.2023.307269 )
Neglected Elderly: Lacking Welfare Policies in Indonesian Local Governments
Authors: Akbar Said Fitra , Phahlevy Rifqi Ridlo 
Published: April 2023

This study aimed to examine the social welfare policies for elderly citizens in local government in Indonesia, with a particular focus on the existence of regional regulations that address the needs of this vulnerable population. A normative method was employed, utilizing a statutory approach and deductive analysis of legal materials. The results of the study indicate that not all regions in Indonesia have local regulations that specifically address the welfare of the elderly. This finding highlights the need for increased attention and action from local governments in order to ensure the well-being and protection of elderly citizens.
Highlights:

The study focused on social welfare policies for the elderly in local government in Indonesia.
The research revealed that not all regions in Indonesia have local regulations that specifically address the welfare of the elderly.
This highlights the need for increased attention and action from local governments to ensure the well-being and protection of elderly citizens.
Standardization of Complex Well Planning and Operations Through Organizational and Digital Transformations
Authors: Corona Mauricio , Franco Nata , Alvidrez Jesus 
Published: April 2023

Abstract
Complex well operations environment typically requires customized or unique solution for each well or challenge. The absence of standardized practices and constant "reinventing the wheel" leads to a lack of consistency and performance. A focus on standardization of well planning and operations has helped to eliminate areas of unnecessarily individual solutions. Digital and organizational transformations enabled consistency in well design, risk assessment and practices, as well a relentless focus on best-in-class execution.
The lack of collaboration between the business lines complicated the interfaces required between teams and resulted in variations between rigs, based often on personal preferences and individual lessons learned rather than technical or operational justifications. The complexity imbedded into field, complex well planning and operations created additional challenges in achieving excellent execution results and made it difficult to have predictable performance. The authors proposed a new way to manage this process across the organization to reduce variability.
A central well engineering design team was created, and it is core for the creation of standard drilling and completion programs, procedures and standards practices. The learning loop process is in place to ensure lessons learned and improved practices are updated in the standard procedures. The drilling team started their digital transformation by adopting to the new digital well planning solution for designing new wells, enhancing the engineering work, improving the overall planning processes, and generating drilling programs. Leveraging the built-in key functionalities enabled the drilling team to optimize their planning workflow and produce coherent drilling programs while improving planning efficiency. Throughout the deployment, the digital well planning solution promoted the collaboration between multi-disciplinary teams, allowing team members to work together in one virtual workspace where all relevant data is accessible to all engineers.
Standardization is a critical success factor to ensure the future competitiveness of any operator in challenging environment. Implementation of standardization drives towards expected outcomes and reduces the number of and occurrence of unplanned events. Technical and operational assurance is streamlined, utilization of junior engineering staff improves, and reduction in recycle time are additional benefits of standardization. This project details how a standard well engineering and design team and digital technologies were incorporated into the integrated well construction department to create a common framework for standard planning and operations, and how that helped on project's outperformance.
Mapping Circular Economy in Oil and Gas Facility
Authors: Al Rashid Mubarak 
Published: April 2023

Summary
Oil and Gas remain critical components of the world's energy supply mix and there is an increasing need for minimizing the environmental impact associated with hydrocarbons. To address the trilemma of sustainability issues, including resources depletion, waste accumulation and ecosystem degradation, Abqaiq Plants, where over 5% of global oil production is processed, has established and embedded a systematic Circular Economy program for identifying business opportunities to reduce environmental impacts and GHG while improving economic and environmental sustainability.
The aim of the circular economy is therefore to make the most of the material resources available to us by applying three basic principles: reduce, reuse and recycle. In this way, the life span of products is extended, waste is used and a more sustainable transition model is established over time. The idea of circular economy ascends from imitating nature, where everything has value and everything is used, where waste becomes a new resource. By implementing circular economy, the balance between progress and sustainability is maintained.