bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous bilateral quadriceps tendon rupture in a healthy young male: a case report
Authors: Sasaki Ryo , Nagashima Masaki , Aibara Noriyuki , Aomatsu Shuji , Aida Shinsuke , Takeshima Kenichiro , Ishii Ken 
Published: March 2023

Abstract
Background
Simultaneous bilateral quadriceps tendon rupture is rare, particularly in young individuals with no prior medical history. We present the case of a young man who presented with bilateral quadriceps tendon rupture.

Case presentation
A 27-year-old Japanese man missed a step while descending a flight of stairs, stumbled, and became aware of severe pain in both knees. He had no past medical history, but was severely obese, with a body mass index of 43.7 kg/m2 (height 177 cm, weight 137 kg). Five days after injury, he was referred to our hospital for examination and treatment. Bilateral quadriceps tendon rupture was diagnosed based on magnetic resonance imaging, and quadriceps tendon repair with suture anchor was performed on both knees 14 days after injury. The postoperative rehabilitation protocol was to immobilize both knees in extension for 2 weeks, then to gradually proceed with weight-bearing and gait training using hinged knee braces. Both knees obtained a range of motion from 0° to 130° without any extension lag by 3 months postoperatively. One year postoperatively, tenderness was evident at the suture anchor in the right knee. That suture anchor was therefore removed in a second operation, and histological evaluation of the tendon of the right knee revealed no pathological changes. As of 19 months after the primary surgery, the patient showed a range of motion from 0° to 140° in both knees, did not complain of any disability, and had fully returned to normal daily activities.

Conclusions
We experienced simultaneous bilateral quadriceps tendon rupture in a 27-year-old man with no past medical history other than obesity. Suture anchor repair was performed for both quadriceps tendon ruptures and achieved a favorable postoperative outcome.
A lightweight convolutional neural network based on dense connection for open-pit coal mine service identification using the edge-cloud architecture
Authors: Liu Yang , Zhang Jin 
Published: March 2023

AbstractRemote sensing is an important technical tool for rapid detection of illegal mining behavior. Due to the complex features of open-pit coal mines, there are few studies about automatic extraction of open-pit coal mines. Based on Convolutional Neural Network and Dense Block, we propose a lightweight densely connected network-AD-Net for the extraction of open-pit coal mining areas from Sentinel-2 remote sensing images, and construct three sample libraries of open-pit coal mining areas in north-central Xinzhou City, Shanxi Province. The AD-Net model consists of two convolutional layers, two pooling layers, a channel attention module, and a Dense Block. The two convolutional layers greatly reduce the complexity of the model, and the Dense Block enhances the feature propagation while reducing the parameter computation. The application is designed in different modules that runs independently on different machines and communicate with each other. Furthermore, we create and build a unique remote sensing image service system that connects a remote datacentre and its associated edge networks, employing the edge-cloud architecture. While the datacentre acts as the cloud platform and is in charge of storing and processing the original remote sensing images, the edge network is largely utilised for caching, predicting, and disseminating the processed images. First, we find out the optimal optimizer and the optimal size of the input image by extensive experiments, and then we compare the extraction effect of AD-Net with AlexNet, VGG-16, GoogLeNet, Xception, ResNet50, and DenseNet121 models in the study area. The experimental results show that the combination of NIR, red, green, and blue band synthesis is more suitable for the extraction of the open-pit coal mine, and the OA and Kappa of AD-Net reach 0.959 and 0.918 respectively, which is better than other models and well balances the classification accuracy and running speed. With this design of edge-cloud, the proposed system not only evenly distributes the strain of processing activities across the edges but also achieves data efficiency among them, reducing the cost of data transmission and improving the latency.
Rumen microbial-driven metabolite from grazing lambs potentially regulates body fatty acid metabolism by lipid-related genes in liver
Authors: Li Zhen , Zhao Xingang , Jian Luyang , Wang Bing , Luo Hailing 
Published: March 2023

AbstractBackgroundLipid metabolism differs significantly between grazing and stall-feeding lambs, affecting the quality of livestock products. As two critical organs of lipid metabolism, the differences between feeding patterns on rumen and liver metabolism remain unclear. In this study, 16S rRNA, metagenomics, transcriptomics, and untargeted metabolomics were utilized to investigate the key rumen microorganisms and metabolites, as well as liver genes and metabolites associated with fatty acid metabolism under indoor feeding (F) and grazing (G).ResultsCompared with grazing, indoor feeding increased ruminal propionate content. Using metagenome sequencing in combination with 16S rRNA amplicon sequencing, the results showed that the abundance of propionate-producingSucciniclasticumand hydrogenating bacteria Tenericutes was enriched in the F group. For rumen metabolism, grazing caused up-regulation of EPA, DHA and oleic acid and down-regulation of decanoic acid, as well as, screening for 2-ketobutyric acid as a vital differential metabolite, which was enriched in the propionate metabolism pathway. In the liver, indoor feeding increased 3-hydroxypropanoate and citric acid content, causing changes in propionate metabolism and citrate cycle, while decreasing the ETA content. Then, the liver transcriptome revealed that 11 lipid-related genes were differentially expressed in the two feeding patterns. Correlation analysis showed that the expression ofCYP4A6,FADS1,FADS2,ALDH6A1andCYP2C23was significantly associated with the propionate metabolism process, suggesting that propionate metabolism may be an important factor mediating the hepatic lipid metabolism. Besides, the unsaturated fatty acids in muscle, rumen and liver also had a close correlation.ConclusionsOverall, our data demonstrated that rumen microbial-driven metabolite from grazing lambs potentially regulates multiple hepatic lipid-related genes, ultimately affecting body fatty acid metabolism.
A 40-year study of child maltreatment over the early life course predicting psychiatric morbidity, using linked birth cohort and administrative health data: protocol for the Childhood Adversity and Lifetime Morbidity (CALM) study
Authors: Kisely Steve , Leske Stuart , Arnautovska Urska , Siskind Dan , Warren Nicola , Northwood Korinne , Suetani Shuichi , Najman Jake Moses 
Published: March 2023

Background
Child maltreatment is a major public health issue worldwide. Retrospective studies show a strong association between self-reported child maltreatment and poor mental and physical health problems. Prospective studies that use reports to statutory agencies are less common, and comparisons of self- and agency-reported abuse in the same cohort even rarer.

Aims
This project will link state-wide administrative health data with prospective birth cohort data (N = 7223) from Brisbane in Queensland, Australia (including notifications to child protection agencies), to compare psychiatric outcomes in adulthood of agency- and self-reported child maltreatment while minimising attrition bias.

Method
We will compare people with all forms of self- and agency-reported child maltreatment to the rest of the cohort, adjusting for confounding in logistic, Cox or multiple regression models based on whether outcomes are categorical or continuous. Outcomes will be hospital admissions, emergency department presentations or community/out-patient contacts for ICD-10 psychiatric diagnoses, suicidal ideation and self-harm as recorded in the relevant administrative databases.

Conclusions
This study will track the life course outcomes of adults after having experienced child maltreatment, and so provide an evidence-based understanding of the long-term health and behavioural consequences of child maltreatment. It will also consider health outcomes that are particularly relevant for adolescents and young adults, especially in relation to prospective notifications to statutory agencies. Additionally, it will identify the overlap and differences in outcome for two different sources of child maltreatment identification in the same cohort.
Age-Dependent Electroencephalogram Features in Infants Under Spinal Anesthesia Appear to Mirror Physiologic Sleep in the Developing Brain: A Prospective Observational Study
Authors: Santa Cruz Mercado Laura A. , Lee Johanna M. , Liu Ran , Deng Hao , Johnson Jasmine J. , Chen Andrew L. , He Mingjian , Chung Evan R. , Bharadwaj Kishore M. , Houle Timothy T. , Purdon Patrick L. , Liu Chang A. 
Published: March 2023

BACKGROUND:
Infants under spinal anesthesia appear to be sedated despite the absence of systemic sedative medications. In this prospective observational study, we investigated the electroencephalogram (EEG) of infants under spinal anesthesia and hypothesized that we would observe EEG features similar to those seen during sleep.

METHODS:
We computed the EEG power spectra and spectrograms of 34 infants undergoing infraumbilical surgeries under spinal anesthesia (median age 11.5 weeks postmenstrual age, range 38–65 weeks postmenstrual age). Spectrograms were visually scored for episodes of EEG discontinuity or spindle activity. We characterized the relationship between EEG discontinuity or spindles and gestational age, postmenstrual age, or chronological age using logistic regression analyses.

RESULTS:
The predominant EEG patterns observed in infants under spinal anesthesia were slow oscillations, spindles, and EEG discontinuities. The presence of spindles, observed starting at about 49 weeks postmenstrual age, was best described by postmenstrual age (P=.002) and was more likely with increasing postmenstrual age. The presence of EEG discontinuities, best described by gestational age (P = .015), was more likely with decreasing gestational age. These age-related changes in the presence of spindles and EEG discontinuities in infants under spinal anesthesia generally corresponded to developmental changes in the sleep EEG.

CONCLUSIONS:
This work illustrates 2 separate key age-dependent transitions in EEG dynamics during infant spinal anesthesia that may reflect the maturation of underlying brain circuits: (1) diminishing discontinuities with increasing gestational age and (2) the appearance of spindles with increasing postmenstrual age. The similarity of these age-dependent transitions under spinal anesthesia with transitions in the developing brain during physiological sleep supports a sleep-related mechanism for the apparent sedation observed during infant spinal anesthesia.
Trial Fabrication of NADH-Dependent Enzymatic Ethanol Biofuel Cell Providing H2 Gas as well as Electricity
Authors: Yano Jun , Suzuki Kenta , Hashimoto Chihiro , Tsutsumi Chikara , Hayase Nobuki , Kitani Akira 
Published: March 2023

Abstract
The oxidative conversion of NADH to NAD+ is a key process for enzymatic biofuel cells to obtain high performance. To promote this conversion, we utilized a photogalvanic cell whose reactions involved the indirect oxidation of NADH mediated by photo-excited flavinmononucleotide (FMN) at the anode and electroreduction of H+ to produce H2 gas at the cathode. Based on the relationship between the passing charge and the concentration changes in NADH, NAD+, and FMN during the discharge, it was determined that the FMN-mediated oxidation of NADH quantitatively proceeded. The enzymatic biofuel cell was fabricated using this photogalvanic cell. By introducing both the ethanol biofuel and alcohol dehydrogenase (ADH) to the photogalvanic cell, the cell current continued to flow because NAD+ was converted to NADH by the biofuel and the enzyme. This cell provided not only electricity, but also H2 gas as a by-product. This is an advantageous feature, which typical enzymatic fuel cells do not possess.
Ischemic Preconditioning Acutely Improves Functional Sympatholysis during Handgrip Exercise in Healthy Males but not Females
Authors: TEIXEIRA ANDRÉ L. , GANGAT AYESHA , BOMMARITO JULIAN C. , BURR JAMIE F. , MILLAR PHILIP J. 
Published: March 2023

ABSTRACT

Purpose
Ischemic preconditioning (IPC), a procedure that involves the cyclic induction of limb ischemia and reperfusion via tourniquet inflation, has been reported to improve exercise capacity and performance, but the underlying mechanisms remain unclear. During exercise, sympathetically mediated vasoconstriction is dampened in active skeletal muscle. This phenomenon, termed functional sympatholysis, plays a critical role in maintaining oxygen delivery to working skeletal muscle and may contribute to determining exercise capacity. Herein, we investigate the effects of IPC on functional sympatholysis in humans.

Methods
In 20 (10M/10F) healthy young adults, forearm blood flow (Doppler ultrasound) and beat-to-beat arterial pressure (finger photoplethysmography) were measured during lower body negative pressure (LBNP; −20 mm Hg) applied at rest and simultaneously during rhythmic handgrip exercise (30% maximum contraction) before and after local IPC (4 × 5-min 220 mm Hg) or sham (4 × 5-min 20 mm Hg). Forearm vascular conductance (FVC) was calculated as forearm blood flow/mean arterial pressure and the magnitude of sympatholysis as the difference of LBNP-induced changes in FVC between handgrip and rest.

Results
At baseline, LBNP decreased FVC (females [F] = ∆–41% ± 19%; males [M] = ∆–44% ± 10%), and these responses were attenuated during handgrip (F = ∆–8% ± 9%; M = ∆–8% ± 7%). After IPC, LBNP induced similar decreases in resting FVC (F = ∆–37% ± 19%; M = ∆–44% ± 13%). However, during handgrip, this response was further attenuated in males (∆–3% ± 9%, P = 0.02 vs pre) but not females (∆–5% ± 10%, P = 0.13 vs pre), which aligned with an IPC-mediated increase in sympatholysis (M-pre = 36% ± 10% vs post = 40% ± 9%, P = 0.01; F-pre = 32% ± 15% vs post = 32% ± 14%, P = 0.82). Sham IPC had no effect on any variables.

Conclusions
These findings highlight a sex-specific effect of IPC on functional sympatholysis and provide evidence of a potential mechanism underlying the beneficial effects of IPC on human exercise performance.
Do Differences in Analyst Quality Matter for Investors Relying on Consensus Information?
Authors: Michaely Roni , Rubin Amir , Segal Dan , Vedrashko Alexander 
Published: March 2023

This study investigates whether investors can reap economic benefits from analyzing differences in analyst quality. Although high-quality analysts’ average forecast is more accurate than the consensus forecast for firms with a large analyst following, the benefits of using high-quality analysts’ average forecasts are not economically significant. In contrast, the value of analyst quality differentiation exists in the second moment of forecasts. High-quality analysts’ forecast dispersion gives investors an advantage in dealing with uncertainty by predicting return volatility and providing opportunities for economically significant returns using option straddle and post-earnings announcement drift investment strategies. This paper was accepted by Suraj Srinivassan, accounting. Funding: A. Rubin and A. Vedrashko thank the financial support of the Social Sciences and Humanities Research Council of Canada (SSHRC). Supplemental Material: The data are available at https://doi.org/10.1287/mnsc.2023.4699 .
Monomeric CRP regulates inflammatory responses in human intervertebral disc cells
Authors: Ruiz-Fernández Clara , Ait Eldjoudi Djedjiga , González-Rodríguez Maria , Cordero Barreal Alfonso , Farrag Yousof , García-Caballero Lucia , Lago Francisca , Mobasheri Ali , Sakai Daisuke , Pino Jesús , Gualillo Oreste 
Published: March 2023

AimsCRP is an acute-phase protein that is used as a biomarker to follow severity and progression in infectious and inflammatory diseases. Its pathophysiological mechanisms of action are still poorly defined. CRP in its pentameric form exhibits weak anti-inflammatory activity. The monomeric isoform (mCRP) exerts potent proinflammatory properties in chondrocytes, endothelial cells, and leucocytes. No data exist regarding mCRP effects in human intervertebral disc (IVD) cells. This work aimed to verify the pathophysiological relevance of mCRP in the aetiology and/or progression of IVD degeneration.MethodsWe investigated the effects of mCRP and the signalling pathways that are involved in cultured human primary annulus fibrosus (AF) cells and in the human nucleus pulposus (NP) immortalized cell line HNPSV-1. We determined messenger RNA (mRNA) and protein levels of relevant factors involved in inflammatory responses, by quantitative real-time polymerase chain reaction (RT-qPCR) and western blot. We also studied the presence of mCRP in human AF and NP tissues by immunohistochemistry.ResultsWe demonstrated that mCRP increases nitric oxide synthase 2 (NOS2), cyclooxygenase 2 (COX2), matrix metalloproteinase 13 (MMP13), vascular cell adhesion molecule 1 (VCAM1), interleukin (IL)-6, IL-8, and Lipocalin 2 (LCN2) expression in human AF and NP cells. We also showed that nuclear factor-κβ (NF-κβ), extracellular signal-regulated kinase 1/2 (ERK1/2), and phosphoinositide 3-kinase (PI3K) are at play in the intracellular signalling of mCRP. Finally, we demonstrated the presence of mCRP in human AF and NP tissues.ConclusionOur results indicate, for the first time, that mCRP can be localized in IVD tissues, where it triggers a proinflammatory and catabolic state in degenerative and healthy IVD cells, and that NF-κβ signalling may be implicated in the mediation of this mCRP-induced state.Cite this article:Bone Joint Res 2023;12(3):189–198.
A scoping review of the outcome reporting following surgery for chronic osteomyelitis of the lower limb
Authors: Camilleri-Brennan Julian , James Sophie , McDaid Catriona , Adamson Joy , Jones Katherine , O'Carroll Grace , Akhter Zohaib , Eltayeb Momin , Sharma Hemant 
Published: March 2023

AimsChronic osteomyelitis (COM) of the lower limb in adults can be surgically managed by either limb reconstruction or amputation. This scoping review aims to map the outcomes used in studies surgically managing COM in order to aid future development of a core outcome set.MethodsA total of 11 databases were searched. A subset of studies published between 1 October 2020 and 1 January 2011 from a larger review mapping research on limb reconstruction and limb amputation for the management of lower limb COM were eligible. All outcomes were extracted and recorded verbatim. Outcomes were grouped and categorized as per the revised Williamson and Clarke taxonomy.ResultsA total of 3,303 records were screened, of which 99 studies were included. Most studies were case series (77/99; 78%) and assessed one method of reconstruction (68/99; 69%). A total of 511 outcomes were reported, which were grouped into 58 distinct outcomes. Overall, 143/511 of all outcomes (28%) were provided with a clear, in-text definition, and 231 outcomes (45%) had details reported of how and when they were measured. The most commonly reported outcome was ‘recurrence of osteomyelitis’ (62; 12%). The single-most patient-reported outcome measure was ‘pain’.ConclusionThis study has highlighted significant inconsistencies in the defining, reporting, and measuring of outcomes across studies investigating surgical management for chronic osteomyelitis of the lower limb in adults. Future studies should clearly report complete details of how outcomes are defined and measured, including timing. The development of a standardized core outcome set would be of significant benefit in order to allow evidence synthesis and comparison across studies.Cite this article: Bone Jt Open 2023;4(3):146–157.
Improving HIV stigma in the marginalized population in Khorramabad, Iran: A single-blinded randomized, controlled educational trial using role-playing and lecturing
Authors: Jomezadeh Mina , Zamani-Alavijeh Fereshteh , Aleebrahim Forugh , Nasirian Maryam 
Published: March 2023

This study aimed to investigate the effect of role-playing and lecture on improving the attitudes of the Khorramabad suburban population toward the human immunodeficiency virus (HIV). In 2019, 270 people aged 18 and above participated in a randomized controlled trial in Khorramabad, Iran. Individuals were randomly assigned to one of three groups: role-playing, lecture, or control. To collect data before and after the intervention, we used a standard HIV knowledge and attitude questionnaire. Before the educational intervention, three marginalized groups’ attitudes toward HIV were stigmatized. After the intervention, the attitudes of both the role-playing and lecture groups improved significantly relative to the control group (P<0.0001); there was no significant difference between the two methods (P>0.05). The correlation between attitude and knowledge scores was positive (P<0.0001). This study demonstrates that education is a fundamental pillar of improving attitudes toward people living with HIV (PLHIV) and can reduce stigma against them, thereby increasing their desire to disclose their condition and seek medical care.
Trial registration: The trial registration code is IRCTID: IRCT20190807044467N1 (https://en.irct.ir/trial/41464).
Circulating Fear: Japanese Horror, Fractured Realities, and New Media, Lindsey Nelson (2021)
Authors: Thomas-Parr Georgia 
Published: March 2023

Review of: Circulating Fear: Japanese Horror, Fractured Realities, and New Media, Lindsey Nelson (2021)
Lexington, KY: Rowman & Littlefield, 148 pp.,
ISBN 978-1-79361-367-7, h/bk, $90.00
Mind Beyond Brain: Buddhism, Science and the Paranormal, David E. Presti (Ed.) (2021)
Philosophy’s Big Questions: Comparing Buddhist and Western Approaches, Steven M. Emmanuel (Ed.) (2021)
The Transcendental and the Mundane: Chinese Cultural Values in Everyday Life, Cho-Yun Hsu and David Ownby (Trans.) (2021)
Authors: Ionescu Mihaela Cristina 
Published: March 2023

Review of: Mind Beyond Brain: Buddhism, Science and the Paranormal, David E. Presti (Ed.) (2021)
New York: Columbia University Press, 213 pp.,
ISBN 978-0-23118-957-6, p/bk, £20.00/$25.00

Philosophy’s Big Questions: Comparing Buddhist and Western Approaches, Steven M. Emmanuel (Ed.) (2021)
New York: Columbia University Press, 317 pp.,
ISBN 978-0-23117-487-9, p/bk, £25.00/$30.00

The Transcendental and the Mundane: Chinese Cultural Values in Everyday Life, Cho-Yun Hsu and David Ownby (Trans.) (2021)
Sha Tin: The Chinese University of Hong Kong Press, 279 pp.,
ISBN 978-9-88237-212-2, h/bk, $60.00