bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacognostic study and high-performance liquid chromatography finger print profile of herbs of Hridyadashemani
Authors: Narayan Rao Harini Aswatha , Siddalingaiah Veena Mullur , Ramachandraiah Lalitha B. 
Published: August 2023

Abstract

BACKGROUND:
In Ayurveda, medicinal plants have been organized into various categories based on several parameters. One such classification is based on actions, wherein the therapeutic agents have been categorized into 50 groups. Among these, Hridyadashemani is one that includes the fruits of Amra, Amrataka, Lakucha, Karamarda, Vrukshamla, Amlavetasa, Kuvala, Badara, Dadima, and Matulunga. The objective of this study was to identify and develop preliminary analytical standards for the ten herbs of Hridyadashemani.

METHODS:
The herbs were collected from their natural habitat and subjected to macroscopic and microscopic evaluation as per standard procedures. The analytical study that includes foreign matter (%w/w), total ash (%w/w), acid insoluble ash (%w/w), alcohol-soluble extractive (%w/w), and water-soluble extractive (% w/w) of the herbs were conducted as per standard pharmacopeial guidelines. Preliminary phytochemical evaluation and high-performance liquid chromatography (HPLC) analysis of the herbs for the presence of quercetin and gallic acid were carried out.

RESULTS:
The macroscopic and microscopic features of the fresh and dried fruits were documented and compared to published literature. The analytical standards were recorded and compared to pharmacopeial standards and published literature. The herbs were found to contain various quantities of quercetin and gallic acid. These phytochemicals may have a potential role in cardiovascular diseases.

CONCLUSION:
The preliminary analytical findings include HPLC finger print profile which would serve as a monograph for Hridyadashemani. Further studies may be taken up to analyze the use of these herbs in various cardiovascular diseases.
Pharmaceutical development of Lekhaniya Mahakashaya into dispersible tablet–A polyherbal formulation
Authors: Sakshi  , Hiremath Rajendraswami S. , Mannur Vinod Shrishaila 
Published: August 2023

Abstract

BACKGROUND:

Lekhaniya Mahakashaya (LM) is indicated in Ayurveda for obesity. Its classical dosage form is Kashaya (decoction), which involves time-consuming preparation and has a low shelf-life. The aim of the study was, therefore, to modify the dosage form of LM into a dispersible tablet (DT), a unit solid dosage form close to decoction, due to its conversion into aqueous solution during administration.

METHODS:
Raw materials were authenticated as per API standards. To develop and optimize the DT, totally six trials for each of the 30 tablets were carried out by direct compression method using two super disintegrants, viz., Sodium Starch Glycolate (SSG) and Croscarmellose Sodium, with the effervescent agents, tartaric acid, and sodium bicarbohydrate. The developed formulation was analyzed for its pre- and post-compression parameters besides Fourier transform infrared (FTIR).

RESULTS:
The formulation made using Anhydrous Lactose (AL) as a binding agent and SSG as a super disintegrant passed all the quality parameters of a DT. The average weight was 500 mg. The angle of repose was 0.600, Carr’s index was 19.40, and Hausner’s ratio was 1.24. Disintegration time was 2.5 min, friability was less than 1%, hardness was 2.5, and weight variation was less than 5%. FTIR revealed the presence of functional groups such as phenolics, alcohol, alkene, and nitride.

CONCLUSION:
LM can be modified into a DT using AL as a binding agent and SSG as a super disintegrant. Further studies are warranted to fix the clinical dose and assess efficacy.
Pharmaceutical standardization and analytical validation of Sanjivani Vati
Authors: Kaushik Shreshtha , Yadav Pramod , Prajapati Pradeep Kumar 
Published: August 2023

Abstract

BACKGROUND:
Standardization and validation for Ayurvedic polyherbal preparation using modern techniques of analysis are extremely important. Sanjivani Vati (SV) is one such a multicomponent formulation, which is well known for its multiple uses. Even so, it lacks the latest scientific measures to ensure its safety and efficacy more precisely. So, an attempt has been made to standardize the pharmaceutical procedure of SV and to validate its analytical profile. To develop Standard Manufacturing Procedure (SMP) of SV and to validate its quality control parameters.

METHODS:
Five batches of SV were prepared in the pharmaceutical laboratory, All India Institute of Ayurveda, New Delhi, India, following a classical reference. They were further subjected to an organoleptic, relevant physicochemical and physical, heavy metal, and microbial limit analysis along with a chromatographic as well as spectroscopic evaluation, that is, Fourier transform infrared spectroscopy (FTIR) and gas chromatography-mass spectrum (GCMS).

RESULTS:
A batch size of 100 g of SV can be prepared by using 10 g of its each ingredient, 250 mL of cow’s urine required for levigation of 6 h 45 min with a yield of around 730 pills of average weight 130.64 ± 2.43 mg, and after drying for 5 h 52 min at 50°C. These findings accomplished the chief objective of its pharmaceutical standardization. Analytical specifications of SV are highly amorphous powder, mild bitter in taste with odor of cow’s urine and having brownish black color. All the physicochemical parameters were found validated as per official standards except total ash value. Moreover, FTIR showed the presence of hydroxy, alkane, amide, acyl, alkoxy, and aromatic compounds. Fingerprinting assay revealed seven and nine retardation factor values at 254 and 366 nm, respectively. Furthermore, a total of 21 compounds were detected in GCMS. Pills were also observed free from specific heavy metals, microbes, and pesticides indicating good manufacturing practices.

CONCLUSION:
This is a preliminary report generating results for standardization as well as validation of SV that could be used for future references. Moreover, further works should be carried out to explore the therapeutic outcomes of this medication.
Effects of propofol-based total intravenous anesthesia versus desflurane anesthesia on natural killer cell cytotoxicity after hepatocellular carcinoma resection
Authors: Apisutimaitri Kirada , Saeyup Pipat , Suppipat Koramit , Sirichindakul Pongserath , Wanasrisant Nattanit , Nonsri Chawisachon , Lertprapai Panas 
Published: August 2023

Abstract

Background and Aims:
Inhalation anesthesia suppresses the immune system and stimulates the growth of tumor cells, contrary to intravenous anesthesia. However, no consensus exists on which anesthetic technique is better for preventing cancer recurrence. Therefore, this study compared the effects of two different anesthetic techniques on natural killer cell cytotoxicity (NKCC) in hepatocellular carcinoma (HCC) patients undergoing open hepatic resection.

Material and Methods:
Patients diagnosed with nonmetastatic HCC were scheduled for hepatic resection and randomly assigned to receive either propofol- or desflurane-based anesthesia. The primary outcome was pre- and postoperative NKCC assay. Cytokine levels were assessed by measuring interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ) levels, and the secondary outcome was postoperative cancer recurrence evaluated using diagnostic imaging scans for 2 years.

Results:
Twenty-eight patients were analyzed, including 15 and 13 in the total intravenous anesthesia (TIVA) and inhalation (INH) groups, respectively. Two patients in the INH group were excluded due to non-HCC postoperative pathologic results. At 24 h, the postoperative change in NKCC between both groups showed no significant differences at a ratio of effector cell: target cell = 1:1, 5:1, and 10:1 (P = 0.345, 0.345, and 0.565, respectively). Also, there were no significant differences in IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels (P = 0.588, 0.182, 0.730, 0.076, 0.518, 0.533, respectively). Postoperative tumor recurrence occurred in five and six patients in the TIVA and INH groups, respectively.

Conclusion:
NKCC did not differ significantly among HCC patients undergoing open hepatic resection under either propofol or desflurane anesthesia 24 h postoperatively.
Use of ultrasound to estimate the prevalence of occult spinal dysraphism in children undergoing urogenital and anorectal surgeries: A cross-sectional study
Authors: Toms Ann Sumin , Rai Ekta , John Novin Chacko , Panwar Jyoti 
Published: August 2023

Abstract

Background and Aim:
The use of ultrasound has immensely increased the safety toward regional blocks and central venous access and has been considered as the standard of care for securing central access. The aim of this study is to estimate the prevalence of occult spinal dysraphism using ultrasound in children less than 2 years of age undergoing elective urogenital or anorectal surgery.

Material and Methods:
The lumbosacral region of 159 American Society of Anesthesiologists (ASA) category I/II patients, posted for elective urogenital and anorectal surgery was scanned with ultrasound, prior to giving caudal block.

Results:
The prevalence of occult spina bifida was 3% in our study. There was no statistically significant association of cutaneous marker with abnormal scan.

Conclusion:
Prevalence of occult spina bifida was ten-times higher in our study than in the general population. Perioperative ultrasound screening of the lower spinal anatomy by anesthesiologist done prior to performing neuraxial block is worthwhile in ruling out occult spinal anomalies in high-risk children of occult spinal dysraphism.
Duha Prayer in Improving the Spiritual Intelligence of Grade VIII Students at MTS Miftahul Huda
Authors: Fitriana Fitriana , A  Hasyim Umar Al Faruq , Irhamudin Irhamudin 
Published: August 2023

This article aimed to determine the effect of Duha prayer in improving the spiritual intelligence of Grade VIII students at MTs Miftahul Huda Nambah Dadi Village, Terbanggi Besar District Central Lampung Regency. This study used a qualitative method. The subjects was 30 participants. Data collection used documentation and questionnaires. While the technique analyzing data used triangulation. The results showed that Duha prayer is very influential in increasing spiritual intelligence. The process of forming spiritual intelligence in madrasas is in the form of habituating religious activities, educating morals on a spiritual basis (aqidah and faith) which directs students to reach the degree of ihsan. Religious culture in educational institutions is a culture that was created from the habituation of religious activities that lasts a long time and continuously, even to the point where self-awareness emerges from all members of the educational institution to carry out these religious values. To the extent that their hearts are restless if they do not carry out religious activities or violate the religious culture that has become a habit and a spiritual need for humans.
Keywords: Improving Spiritual Intelligence, Effect of Duha Prayer, Spiritual Intelligence
Edukasi Pemanfaatan Pengawetan Bahan Alam Dengan Metode Simplisia Pada Siswa SMP Pahlawan Medan
Authors: Pangondian Aswan , Athaillah Athaillah , Chandra Putra , Renaldi Refli 
Published: August 2023

Indonesia memiliki sumber daya alam hayatinya yang sangat melimpah. Lebih dari 80.000 spesies atau jenis tumbuhan yang terdapat di dalam Indonesia, baik itu di darat maupun di laut. Hanya Sebagian kecil tumbuhan yang sudah di lakukan penelitian dan pemanfaat tumbuhan sebagai bahan dasar atau obat di masyarakat. Sehingga Masyarakat hanya sedikit yang memahami bagaimana pe manfaatan dan kegunaan dari tumbuhan tersebut. Tumbuhan termasuk dalam metabolit sekunder yang merupakan sumber dari obat-obatan yang sering digunakan dalam pengobatan berbagai jenis penyakit yang diderita oleh manusia. Beberapa tumbuhan yang digunakan untuk berbagai penyakit dimasyarakat adalag sebagai stimulan jantung dan peredaran darah, antitumor, antipiretik, antiepilepsi, antiinflamasi, antiulcer, diuretik, antihipertensi, menurunkan kolesterol, antioksidan, antidiabetik, antibakteri, dan antijamur.
Kegiatan ini dilaksanakan dengan metode pelatihan secara langsung kepada siswa SMP Pahlawan di Kota Medan. Kegiatan dilaksanakan di Sekolah menengah pertama (SMP) Kota Medan, Kecamatan Medan Perjuangan, Kota Medan, Provinsi Sumatera utara, Indonesia. Kegiatan ini dilaksanakan dengan cara sosialisasi dan Praktek, dimulai dari manfaat simplisia serta cara pengolahan pembuatan simplisia kemudian dilanjut dengan Menunjukkan salah satu contoh simplisia yang sudah jadi, lalu menyususn rencana tindak lanjut. Luaran yang diharapkan untuk isntitusi adalah Laporan pengabdian masyarakat dan Jurnal Nasional terakreditasi dan luaran yang diharapkan untuk masyarakat dalam kegiatan ini adalah 1) Terciptanya Pemahaman Masyarakat dalam pemanfaatan pengawetan bahan alam dengan metode simplisia; 2) Terbukanya peluang bisnis bagi masyarakat mitra; 3) Terbentuknya masyarakat yang peduli kesehatan
GIST GÁSTRICO: ESTADO DA ARTE E NEOADJUVÂNCIA
Authors: Leite Pither Paul Silva , Lima Querollen Ágata Silveira , Ribeiro Tatiane da Conceição , Amorim Carlos Augusto 
Published: August 2023

INTRODUÇÃO: O GIST (gastrointestinal stromal tumor), é um tumor estromal gastrointestinal que surge a partir de células de origem mesenquimal, que se localizam na musculatura lisa responsável pela movimentação do trato digestivo, chamadas células de Cajal, também chamadas de “células de marca passo”. Corresponde a cerca de 1% das neoplasias gastrointestinais e cerca de 2% das neoplasias malignas do estômago, embora seja a neoplasia não epitelial mais comum do trato gastrointestinal, sendo encontrado em mais de 50% das vezes neste sítio. Deriva da mutação no gene que codifica o KIT, um receptor transmembrana acoplado a tirosina quinase, que faz parte de uma cascata intracelular que controla funções básicas como proliferação e sobrevivência. DIAGNÓSTICO: Na fase inicial, a maior parte dos pacientes são assintomáticos e o tumor pode ser diagnosticado de forma incidental. Quando há sintomas, os principais são hemorragia e anemia associada. Quando o tumor ocorre no estômago, o paciente pode ter sintomas inespecíficos como perda de peso, distensão abdominal, plenitude pós-prandial, náuseas e vômitos. Na suspeita de lesão maligna, o primeiro passo é a realização de exame de imagem, embora não exista algum exame bem estabelecido. A ultrassonografia endoscópica (EUS) se apresenta como chave importante no diagnóstico por mostrar informações da SEL como: origem das células, natureza da lesão (sólida, cística, gordurosa ou de vasos sanguíneos), e o tamanho da lesão e amostra tecidual satisfatória para as técnicas de imunohistoquímica, o que confirmará o diagnóstico. TRATAMENTO: O principal pilar do tratamento é a ressecção cirúrgica da lesão, sendo a única possibilidade de cura para os pacientes. Todas as lesões com tamanho superior a 2,0 cm ou menores com alguma sintomatologia devem ser ressecadas com margens macroscópicas livres. A adjuvância com imatinib é indicação fundamental para todos os pacientes com moderado e alto risco de recorrência pelos critérios de risco de Fletcher. NEOADJUVÂNCIA: Embora não existam evidências demonstrando melhores resultados para mortalidade em cinco anos ou taxa de recorrência em 1, 2 ou 3 anos, a neoadjuvância é capaz de reduzir o tamanho do tumor, permitir o procedimento com menor morbidade e reduzir o risco de ruptura tumoral e demais complicações pós-operatórias. CONCLUSÃO: A ressecção e o uso de terapia adjuvante com inibidor de tirosina quinase são as únicas terapias com possibilidade de cura até o momento. Dessa forma, a neoadjuvância é indicada apenas para reduzir o tamanho do tumor, reduzindo a morbidade do procedimento, não havendo evidências que indiquem benefício ou mesmo malefício de seu uso.
ANALISIS RISIKO KECELAKAAN KERJA PADA BAGIAN STASIUN PENGGILINGAN DI PT SINERGI GULA NUSANTARA DENGAN METODE JSA DAN HIRARC
Authors: Aprita Trike Aprita Fresa Kurnia , Ayudyah Eka Apsari  
Published: August 2023

PT Sinergi Gula Nusantara (PG Pagotan Madiun) merupakan perusahaan yang bergerak dibidang produksi gula, yang berlokasi dijalan raya Ponorogo, Pagotan, Geger, Kota Madiun. Masalah yang ada pada PG Pagotan Madiun pada saat produksi penggilingan masih mengabaikan keselamatan dan Kesehatan kerja yang dimana hal tersebut memungkinkan terjadinya potensi bahaya kecelakaan kerja pada saat proses penggilingan. Metode Hazard Identification Risk Assesment and Risk Control (HIRARC) merupakan metode yang digunakan dari menentukan jenis kegiatan kerja yang kemudain diidentifikasi sumber bahayanya sehingga di dapatkan risikonya. kemudian akan dilakukan penilaian resiko dan pengendalian risiko untuk mengurangi paparan bahaya yang terdapat pada setiap jenis pekerjaan. Sedangkan Job Safety Analisys merupakan metode yang bertujuan untuk melakukan analisis terhadap potensi bahaya yang ada dan untuk melakukan Langkah pencegahan terhadap risiko kecelakaan yang ada. Setelah dilakukan perhitungan risiko kecelakaan kerja dengan metode Hazard Identification Risk Assesment and Risk Control didapatkan nilai risiko kecelakaan kerja dengan kategori High Risk sebesar 0,52 %, Moderate Risk sebesar 0,47 %, dan Low Risk sebesar 0 %.
Kata kunci: K3, JSA dan HIRARC
USULAN PERBAIKAN KUALITAS PADA SARUNG TANGAN GOLF LOTUS MENGGUNAKAN METODE STATISTICAL QUALITY CONTROL DAN 5W+1H
Authors: Ismail Nandar , Setiafindari Widya 
Published: August 2023

Pengendalian kualitas adalah salah satu kegiatan mengukur dan mengawasi yang dilaksanakan mulai dari pemrosesan bahan, tahap produksi hingga produk jadi. Diketahui bahwa jumlah produk cacat pada CV XYZ periode Juli 2022 - Februari 2023 adalah sebesar 8,42% atau sebanyak 33.903 pcs. Oleh karena itu, tujuan dari penelitian ini adalah untuk mengetahui faktor-faktor penyebab kecacatan produk dan menyusun strategi perbaikan yang tepat untuk meminimasi kecacatan produk. Metode analisis pengendalian kualitas yang digunakan adalah metode statistical quality control dan metode penentuan faktor-faktor penyebab kegagalan produk, yaitu metode 5W+1H. Menurut pengolahan data, faktor utama penyebab kecacatan produk adalah faktor manusia, yaitu ketidakpatuhan terhadap SOP yang berlaku, kelalaian, dan ketergesa-gesaan. Faktor metode yaitu penggunaan teknik jahit yang berbeda. Faktor material yaitu penggunaan bahan baku yang kurang berkualitas seperti kulit atau benang. Faktor mesin yaitu kurangnya intensitas dan kontrol perawatan serta jumlah teknisi perawatan mesin yang kurang memadai. Selain itu, strategi perbaikan yang diusulkan, yang dapat diterapkan dengan memperbarui standart of production (SOP), mencakup pemilihan bahan baku atau metode penjahitan dan pengendalian proses penjahitan, produksi, pelaksanaan program pengembangan karyawan, dan tinjauan berkelanjutan. dengan melakukan inspeksi di seluruh tahap produksi dan pada mesin-mesin produksi. Pengolahan bahan baku sesuai dengan standar perusahaan.
Kata kunci: Pengendalian Kualitas, Kualitas, Pengendalian Kualitas Statistik, 5W+1H.
ANALISIS KEPUASAN PELANGGAN TERHADAP PRODUK CATERING SUGIH MENGGUNAKAN METODE KANO
Authors: Muhammad yogi wibowo  , Andung Jati Nugroho  
Published: August 2023

CV Sugih Rasa merupakan usaha yang bergerak di bidang kuliner yang berdiri sejak tahun 2010. Perusahaan ini telah menargetkan penjualan sebesar 10.000pcs/hari dengan total pendapatan sebesar Rp 2.000.000.000/bulan. Namun dilihat dari bulan Januari – Februari perusahaan ini mengalami penurunan pendapatan yang diakibatkan oleh beberapa faktor seperti masih terdapat keluhan dari berbagai pelanggan, Pada bulan Januari tahun 2023 perusahaan ini memperoleh total pendapatan sebesar Rp 1.850.000.000 sedangkan pada bulan Februari tahun 2023 sebesar Rp 1.525.000.000, dengan jumlah pemesanan rata-rata sebesar 6.000-7.500/hari sedangkan target pada setiap harinya sebesar 10.000pcs. Tujuan utama tidak lain agar konsumen merasa puas atau terpenuhi kebutuhannya dan perusahaan tetap mendapatkan untung walaupun telah melakukan perbaikan berkelanjutan, metode yang di gunakan pada penelitian ini yaitu menggunakan metode kano model dengan melakukan penyebaran kuisoner maka dari hasil penggukuran kuisoner akan di olah dengan munggunakan metode kano. Berdasarkan hasil dari penelitian ini, atribut yang menyebabkan penurunan kepuasan pelanggan pada cetering CV Sugih Rasa ini terdapat empat atribut yang mendapatkan greade M dimana apabila kinerja atribut ini rendah maka kepuasan pelanggan akan sangat menurun, dimana masih terdapat masalan pada atribut tersebut seperti kurangnya kebersihan lingkungan perusahaan, masih kurangnya varian menu yang ditawarkan, kesigapan terhadap konsumen yang akan memesan kemudian ketepatan pada saat pengiriman, Untuk mengatasi perbaikan maka dapat diusulkan menggunakan metode 5W+1H.

Kata kunci : Kepuasan pelanggan, Kano model
ANALISIS KEPUASAN PASIEN JKN-KIS TERHADAP KUALITAS PELAYANAN KESEHATAN DI PUSKESMAS PRABUMULIH TIMUR MELALUI TOOLS KESSAN
Authors: Indriyani Yeni , Lestari Endha Ayu , Sitorus Rico Januar , Kurnia Sri Indra 
Published: August 2023

ABSTRAK
Kepuasan peserta merupakan cerminan kualitas pelayanan kesehatan. Dengan adanya KESSAN dapat dilihat tingkat kepuasan peserta JKN-KIS yang telah melakukan pelayanan Kesehatan di Puskesmas yang dapat menjadi acuan untuk evaluasi kualitas pelayanan pada Puskesmas tersebut, dimana capaian KESSAN pada bulan Mei 2022 sebesar 85 (88 yang artinya tidak puas). Metode: Menggunakan survei analitik dengan menggunakan pendekatan Cross Sectional yang menggunakan kuesioner terhadap 100 responden yaitu pasien JKN-KIS. Berdasarkan hasil analisis diketahui ada hubungan yang bermakna (signifikan) antara kualitas pelayanan kesehatan dengan kepuasan pasien JKN-KIS dengan p-value 0.000 lebih kecil dari nilai ? (0,05), OR 5.800. Dengan demikian peneliti menyimpulkan bahwa kualitas pelayanan kesehatan yang buruk 5.8 kali berisiko untuk membuat pasien merasa tidak puas.
The Etymology of Abbreviations in English and Tajik Diplomatic Terms
Authors: Iskandar Khodzhaev 
Published: August 2023

The article is devoted to one of the important problems of the linguistics the problem of term and terminology. During the research from the etymology of abbreviations point of view we discovered that the majority of etymology of abbreviations in English and Tajik diplomatic terms has their specific lexical features of lexical units of abbreviations and identification of the main ways and features of their translation.
An Analysis of Code-Switching on The Utterances of Agnes Mo on Daniel Mananta Network's Youtube Channel
Authors: Ryeo Park Jin , Wicaksono Andri , Rahmawati Dwi , Yani Novi , Sari Lusi Purnama 
Published: August 2023

This research aimed to analyze the phenomena of Code-Switching which examines the types and reasons for using code-switching used Agnes Monica on Daniel Mananta Network's YouTube channel entitled "Agnes Mo Pernah Punya Toxic Relationship?" which was published on February 11th, 2021. The researchers use Stockwell's (2002) theory that explains about three types of Code Switching, there are tag switching, intersetential switching, and intrasetential switching. In this research, the researchers employ a qualitative descriptive method, which is a research method that aims to explain and interpret reality and the researchers used Observation Method as the way to collect the data. The results and discussion found that there are six code-switching data, two Tag Switching data, two Intersetential Switching data, and two Intrasentential Switching data. And according to Hoffman (1991:116) in Saleh (2017:15), the researchers matched the data we found, that the reasons for the code-switching in Agnes Mo's utterances include the first one is talking about a particular topic, the second, being empathic about something, and the last the intention of clarifying the speech content for the interlocutor.