bluuebunny/crossref_metadata_2025_split huggingface dataset:
Appearance, molecule identification, and phylogenetic analysis of the three Leonurus species used for the treatment of gynecological diseases
Authors: Du Qing , Rong Ziyi , Zhang Chang , Wang Liqiang , Guan Yanjuan , Chen Haimei , Wang Bin , Liu Chang 
Published: June 2023

Abstract
We analyzed and compared the three Leonurus species from appearance characteristics, intrinsic gene contents and functions, gene transcribed spacer regions (ITS2) in the nuclear genome, and the process of evolutionary development. The chloroplast genomes of them were found to be common circular structures with the four regions, the length range from 151236bp to 151689bp including the identical number of 37 tRNA and 8 rRNA. The special trans-spliced rps12 genes with two introns and three exons can be caught sight of L. sibiricus. The isoleucine (AUU) and cysteine (UGC) was the most and least abundant amino acid with the codons ending with most bases of A/U. The eleven hotspot divergent regions and four specific CDS genes were systematically counted with the highest nucleotide diversity. We cloned the DNA sequences of the two chosen IGS regions (atpH-atpI and rps15-ycf1) to develop the DNA barcodes, thus found that sixteen specific variable SNP sites and two Indel sites within the three Leonurus species. Furthermore, the ITS2 DNA sequences of 7 Leonurus species were varied after the 57th base in a total of 221 bases. In the aftermath of evolutional analysis, the three Leonurus species were significantly clustered into one great clade, while they were located at the different sub-branch with similar topology and close relationship of Phlomoides rotata based on the sequences of 64 shared nucleotide and ITS2 DNA. Thus above results can directly offer various evidence to better clarify the specific distinction among the three Leonurus species and their evolutionary history.
Clinical Features and Short-Term Outcomes in Virus-Induced Bradycardia: Comparison Between Covid and non-Covid Infected Patients
Authors: Scuotto Frederico , Marques Mayara Maza , Rodrigues Daniela Pereira , Parravano Daniella Cardoso , Coutinho Enia Lucia , Cirenza Claudio 
Published: June 2023

Abstract
Covid-19 outbreak has drawn attention to the fact that viral infections might present with clinical bradycardia. Seeking its clinical significance, not yet unveiled by the literature, we come across other viral infections that also show clinical bradycardia during its clinical course, such as dengue fever and viral diarrhea. The clinical presentation of the latest seems to be severe, often presenting with orthostatic intolerance and fatigue symptoms, requiring expert consultation irrespective of the infection stage, and in case of dengue fever, frequently during the recovery phase. Meanwhile, in Covid-19 infected patients, the bradycardia observed is mild, frugal, and usually asymptomatic.
Thus, we conducted a comparison between two different groups of patients with viral infection displaying clinical bradycardia during hospital stay: Covid and non-Covid patients regarding clinical and Holter monitoring parameters. All patients had other causes of bradycardia excluded and echocardiography and cardiac biomarkers ruled out acute myocarditis.
The results showed that non-Covid patients presented with significantly lower mean and minimum heart rates (HR) on Holter monitoring, as well as longer times in with HR < 50 beats per minute (bpm). SDNN and pNN>50% were also significantly higher in non-Covid patients. The minimum systolic BP was significantly lower in non-Covid patients.
The study shows that Covid-19 is not the only viral infection that may display with clinical bradycardia, but it’s much milder than other viral infections such as dengue fever and viral diarrhea. It remains unclear the mechanism throughout Covid-related bradycardia comes about.
Legionella in drinking water: the detection method matters
Authors: Zacharias Nicole , Waßer Felix , Freier Lia , Spies Kirsten , Koch Christoph , Pleischl Stefan , Mutters Nico T. , Kistemann Thomas 
Published: June 2023

Abstract

Legionella concentrations in drinking water have been regulated for decades and are evaluated with regard to their concentrations in drinking water plumbing systems (DWPS). The respective action levels differ at the international level. In Germany, the Federal Environment Agency (UBA) specifies the application of ISO 11731 for the detection of legionella in drinking water and gives a binding recommendation for the methods to be used for culturing and evaluation. Effective from 01 March 2019, the UBA recommendation was revised. The utilized culture media in the culture approach were altered, consequently affecting the spectrum of legionella colonies detected in drinking water. Using data from a routine legionella monitoring of a large laboratory, over a period of 6 years and 17,270 individual drinking water samples, allowed us to assess the impact of the alteration on the assessment of DWPS. By comparing the amount of action level exceedances before and after the method change, it could be demonstrated that exceedances are reported significantly more often under the new method. Consequently, the corresponding action level for evaluation of legionella contamination and the resulting risk to human health needs to be revised to avoid the misleading impression of increased health risk.
Design and Evaluation of SLNs Encapsulated Curcumin-based Topical Formulation
for the Management of Cervical Cancer
Authors: Singhai Manu , Pandey Vikas , Ashique Sumel , Gupta Ghanshyam Das , Arora Daisy , Haider Tanweer , Mishra Neeraj 
Published: June 2023

Objective:
Curcumin has the propensity to inhibit cancer growth, slow cancer development, increase chemotherapy
effectiveness, and shield healthy cells from radiation treatment harm. As a result of curcumin's ability to block
several signaling pathways, cervical cancer cells can once again proliferate normally. To optimize topically applied
curcumin-loaded solid lipid nanoparticles (SLNPs) for the treatment of cervical cancer, this study set out to establish
the relationship between design variables and experimental data. It also performed in vitro characterizations to determine
the formulation's efficacy and safety.

Methods:
Curcumin-loaded SLNPs were constructed and optimized using a systematic design of experiment (DoE)
technique. SLNPs that were loaded with curcumin were produced utilizing a cold emulsification ultrasonication process.
Using the Box Behnken Design, it was determined how independent variables (factors) like the quantity of lipid
(A), the quantity of phospholipid (B), and the concentration of surfactant (C) affected the responses of the dependent
variables (responses), such as particle size (Y1), polydispersity index (PDI) (Y2), and entrapment efficiency (EE) (Y3)
(BBD).

Results:
The ideal formulation (SLN9) was chosen using the desirability technique based on 3-D surface response
graphs. Using polynomial equations and three-dimensional surface plots, the influence of independent factors on the
dependent variables was evaluated. The observed responses were almost equal to the levels that the optimal formulation
expected. The improved SLNP gel's shape and other physicochemical characteristics were also assessed, and they
were determined to be ideal. The sustained release profile of the produced formulations was validated by in vitro release
tests. Studies on hemolysis, immunogenic response, and in vitro cell cytotoxicity demonstrate the efficacy and
safety of the formulations.

Conclusion:
To improve the treatment effect, chitosan-coated SLNPs may carry encapsulated curcumin to the desired
location and facilitate its localization and deposition in the desired vaginal tissue.
Model Pemberdayaan Kewirausahaan Mandiri Masyarakat di Masa Pandemi Covid-19: Sebuah Kajian Literatur
Authors: Pratama Andika , Akhyadi Ade Sadikin , Saripah Iip 
Published: June 2023

Abstrak: Pandemi Covid-19 tidak hanya berdampak serius bagi sektor kesehatan tetapi juga membuat sektor ekonomi sangat terpuruk. Banyak masyarakat kehilangan pekerjaan bahkan tidak sedikit yang akhirnya menutup usahanya. Salah satu solusi dari permasalahan ini adalah dengan adanya program pemberdayaan kewirausahaan. Artikel ini bertujuan untuk membahas solusi dalam membangun kemandirian ekonomi masyarakat serta berbagai model pemberdayaan kewirausahaan masyarakat di masa pandemi Covid-19 dengan menghimpun dari berbagai artikel yang relevan. Metode penelitian ini menggunakan studi literatur dengan menganalisis berbagai artikel yang membahas mengenai pemberdayaan ekonomi rakyat di masa pandemi Covid-19. Hasil temuan menunjukkan bahwa terdapat berbagai solusi dalam membantu memulihkan ekonomi masyarakat di masa pandemi Covid-19 yaitu dengan memanfaatkan bantuan stimulus dari pemerintah (top down) maupun program pemberdayaan kewirausahaan yang lahir dari masyarakat itu sendiri (bottom up). Selain itu berbagai model pemberdayaan kewirausahaan mandiri masyarakat yang dilaksanakan dengan memanfaatkan berbagai potensi yang ada sangat membantu mendorong perekonomian masyarakat. Implikasi temuan yaitu model pemberdayaan kewirausahaan sangat menarik untuk dilakukan penelitian selanjutnya agar dapat menjadi landasan maupun inspirasi untuk meningkatkan perekonomian masyarakat di masa Pandemi Covid-19. Community Entrepreneurship Empowerment Model during the Covid-19 Pandemic: A Literature ReviewAbstract: The Covid-19 pandemic not only had a serious impact on the health sector but also made the economic sector very badly affected. Many people lost their jobs, and even a few ended up closing their businesses. One solution to this problem is the existence of an entrepreneurial empowerment program. This article aims to discuss solutions in building community economic independence as well as various models of community entrepreneurial empowerment during the Covid-19 pandemic by compiling various relevant articles. This research method used literature studies by analyzing various articles that discuss the economic empowerment of the people during the Covid-19 pandemic. The results show that there are various solutions to help the community's economic recovery during the Covid-19 pandemic, namely by utilizing stimulus from the government (top down) and entrepreneurial empowerment programs created by the community itself (bottom up). In addition, various models of community-driven entrepreneurial empowerment that are implemented by utilizing various existing potentials are very helpful in encouraging the community's economy. The implication of these findings is that the entrepreneurial empowerment model is very interesting for further research to be carried out so that it can be a foundation and inspiration to improve the community's economy during the Covid-19 pandemic.
Upaya Penyuluhan Program Keluarga Berencana (KB) dengan Pendekatan Andragogi di UPTD PPKB Pondok Gede
Authors: Arfianisa Anggi , Sutarjo Sutarjo , Danugiri Dadang 
Published: June 2023

Abstrak:Tujuan penelitian ini untuk mendeskripsikan: (1) upaya penyuluhan program keluarga berencana (KB) dengan pendekatan andragogi di UPTD PPKB Pondok Gede, (2) bentuk-bentuk partisipasi masyarakat dalam upaya penyuluhan program keluarga berencana (KB). Metode yang digunakan dalam penelitian ini yaitu metode deskriptif kualitatif dengan pendekatan kualitatif. Hasil dari penelitian ini adalah upaya penyuluhan program keluarga berencana (KB) di UPTD PPKB Pondok Gede cukup efektif, menggunakan bentuk penyuluhan secara kelompok, adanya macam-macam kb memudahkan masyarakat dalam memilih kb yang akan digunakan, bentuk partisipasi kader membantu pihak plkb dalam kegiatan penyuluhan program kb, media yang diberikan plkb memudahkan kader dalam melakukan penyuluhan program kb kepada masyarakat, dengan dukungan dari pihak luar, pembagian tugas sesuai dengan masing-masing sub nya.Counseling Efforts of Family Planning Program with Andragogy Approach In UPTD PPKB Pondok GedeAbstract: The purpose of this research was to describe: (1) counseling efforts of family planning program (KB) with andragogy approach in UPTD PPKB Pondok Gede, (2) the forms of community participation in counseling efforts family planning program. The method used this research is a qualitative descriptive method with a qualitative approach. The results of this research are the counseling efforts of family planning program (KB) in UPTD PPKB Pondok Gede are quite effective, using the form of group counseling, there are various types of family planning that makes it easier for people to choose which family planning program to use, the form of cadre participation helps PLKB in counseling activities for the family planning program, The media provided by PLKB makes it easier for cadres to conduct family planning program counseling to the community, with support from outside parties, the division of tasks according to each sub.
Dukungan Sosial dan Resiliensi pada Anak di Wilayah Perbukitan Gunung Kidul Yogyakarta
Authors: Muthmainah Muthmainah 
Published: June 2023

Abstrak: Kurangnya dukungan sosial dapat menghambat penyesuaian diri seseorang saat menghadapi masalah. Penyebabnya diantaranya keterbatasan individu, baik dari kualitas pendidikan, kesadaran individu, ketersediaan waktu, serta keterbatasan ekonomi. Tujuan penelitian ini adalah mendeskripsikan bentuk dukungan sosial dan resiliensi pada anak di wilayah perbukitan Gunung Kidul Yogyakarta. Metode penelitian yang digunakan adalah etnografi. Subjek penelitian adalah anak yang berusia 5-8 tahun yang tinggal di wilayah perbukitan. Metode pengumpulan data yaitu dengan observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa dukungan sosial dapat membentuk resiliensi pada sebagian anak di wilayah perbukitan. Adapun bentuk dukungan sosial meliputi dukungan dukungan emosional, instrumental, informasi, dan penghargaan yang diberikan orang tua, guru, tokoh masyarakat, dan komunitas. Dukungan sosial diberikan oleh orang tua, guru, tokoh masyarakat, dan komunitas. Resiliensi terbentuk melalui interaksi yang intens, berkesinambungan, didukung dengan kondisi geografis, dan budaya setempat. Interaksi yang terbuka dan penuh perhatian menjadikan resiliensi semakin kuat. Pengasuhan dan penguatan lingkungan mampu membentuk mental seseorang agar mampu beradaptasi dengan kondisi apapun. Social Support and Resilience for Children in the Hills of Gunung Kidul Yogyakarta Abstract: Insufficient social support could hamper someone’s adaptation when face problems. The causes include individual limitations, both from the quality of education, individual awareness, availability of time, and economic limitations. The objective of this research was to describe the form of social support and resilience among children in hills area. The method of the research used is ethnography. The subjects of the research are adolescents between 5-8 years old who live in hills areas. Data collection methods are by observation, interviews, and documentation. The results showed that social support can form resilience in some children in hilly areas. The forms of social support include emotional support, instrumental support, information, and awards given by parents, teachers, community leaders, and the community. Social support is provided by parents, teachers, community leaders, and the community. Resilience is formed through intense, continuous interaction, supported by geographical conditions and local culture. An open and caring interaction makes resilience stronger. Parenting and strengthening the environment can shape a person's mentality to be able to adapt to any conditions.
Pemberdayaan Penyandang Disabilitas Mental Melalui Pelatihan Membatik di Yayasan Jiwa Layang
Authors: S Caecilia Tridjata , Oetopo Ataswarin , Hazmi Fariz Al 
Published: June 2023

Abstrak: Penyandang disabilitas mental (PDM) seperti halnya individu normal yang menaruh perhatian dan ketertarikan pada aktivitas belajar berkesenian. Faktor ketunaan yang disandangnya mempengaruhi kemampuan perseptual dan kemampuan sosial menjalin relasi dengan masyarakat. Realitas tersebut menghendaki dikembangkannya solusi kreatif dengan pendekatan integratif berbeda untuk mengembangkan pelatihan keterampilan. Pelatihan membatik dengan alat cap berbahan kertas dapat menjadi solusi masalah yang dihadapi oleh PDM dan membantu program pengembangan keterampilan di Yayasan Jiwa Layang. Pendekatan craft therapy dapat menciptakan suasana pelatihan yang lebih atraktif dan menyenangkan, sehingga PDM lebih termotivasi untuk lebih produktif dalam membuat beragam jenis karya Batik Cap. Dampak dari aktivitas yang kreatif dan produktif ini dapat meminimalisir kekambuhan PDM dan dapat belajar mandiri dan menjalani kehidupan yang lebih baik. Hasil dari pelatihan menunjukkan peserta berada pada kategori “terampil” dengan persentase nilai rata-rata 2,9, sehingga disimpulkan bahwa peserta dapat membuat karya batik sesuai dengan keterampilan yang diberikan. Empowerment of People with Mental Disabilities through Batik Training at the Jiwa Layang FoundationAbstract: People with mental disabilities (PDM) are like normal individuals who pay attention and are interested in art learning activities. The disability factor that he has affects his perception ability and social ability in building relationships with the community. This reality requires the development of creative solutions with different integrative approaches to developing skills training. Batik training using a paper stamp tool can be a solution to the problems faced by PDM and help the skills development program at the Jiwa Layang Foundation. The craft therapy approach can create a more interesting and enjoyable training atmosphere, so that PDM is more motivated to be more productive in making various types of Batik Cap works. The impact of these creative and productive activities can minimize the recurrence of PDM and be able to learn independently and live a better life. The results of the training showed that participants were in the "skilled" category with an average score of 2.9, so it was concluded that participants could make batik works according to the skills given.
Community Empowerment Through Making Iboni Craft to Improve Community Welfare and The Economic Impact
Authors: Setyowati Ari Dwi , Yusuf Amin , Malik Abdul , Wang Jingduo 
Published: June 2023

The people of Rowoboni Village have not optimized the potential of water hyacinths in Lake Rawapening. People only work as laborers picking water hyacinths and selling raw to collectors. It does not improve the community’s economy because the selling price of water hyacinths is still lower than that of water hyacinths processed into handicraft products. This study aims to describe the process of water hyacinth Iboni craft community empowerment to improve community welfare and economy. This qualitative approach used in-depth interview techniques with 14 participants consisting of one manager, seven workers, four devices village, one farmer, and one hyacinth collector who are considered to have precise information related to the focus of the research. Data collection techniques in this study used observation, interviews, and documentation. Data validity applied source triangulation techniques, and the data were analyzed through data collection, reduction, presentation, and conclusions. The results of this study show that the empowerment process of Iboni craft consists of 3 stages, namely 1) awareness and behavior formation, 2) knowledge and skills transformation, and 3) intellectual and skills enrichment or improvement. The economic impact of this empowerment program is increasing people’s income and welfare. The conclusion is that the empowerment process of Iboni Craft consists of 3 stages: 1) awareness and behavior formation through Dialogical communication or word of mouth to the public, 2) knowledge and skills transformation through group training, and independent training with the manager of Iboni Craft, 3) intellectual and skills enrichment or improvement where the workforce begins to produce independently following consumer demand. The economic impact of this empowerment program is an increase in family income, which can provide the family with a second source of income.
The Contribution of Green Social Workers in Addressing the Impacts of Climate Change in Indonesia
Authors: Ramdani Jaka , Gunawan Budhi , Darwis Rudi Saprudin 
Published: June 2023

Climate change is part of natural disasters accompanied by the process of environmental degradation and harms human life holistically. The impact of climate change has become a serious problem experienced by various society levels, without any exception. Numerous scientific studies explain that climate change triggers various environmental changes that threaten the survival and welfare of society. Climate change adaptation and mitigation become the preventive and repressive strategies for controlling climate change. A continously developed programis the Climate Village Program (Proklim). The main basis of the program is community empowerment to be able to run sustainably. The present research focused on the study of roles, referring to the theory of Green Social Work by Lena Dominelli. The data were analyzed descriptively regarding the role of Green Social Workers concerning the suitability between the theory and practice. The application of the qualitative approach employed in this research was in the form of a case study. The researchers decided to employ the case study method because the what was investigated in this study was considered unique regarding the role of Green Social Workers in the Climate Village Program, which has been developed and implemented by the government. The roles of Green Social Workers were, first, helping to analyze and solve problems and respond to opportunities and challenges faced by farmers in managing their businesses; second, facilitating the learning process of farmers or Forest Farmer Group (KTH) in implementing good and sustainable business governance; third, assisting farmers, Forest Farmer Group (KTH), or community groups in developing institutions to be competitive and productive; fourth, improving the leadership, managerial, and entrepreneurial skills of farmers, Forest Farmer Group (KTH), or community groups;fifth, ensuring farmers' access to information, technology, and other resources in business development, and assisting as well as supervising farmers in improving production and productivity; sixth, being a safeguard of state assets in the form of forests, inviting the community to know, want, and participate in maintaining and protecting forest resources from various forest; seventh, encouraging the community to sustainably adapt and mitigate climate change; eighth, initiating the establishment of the Climate Village Program. Green Social Workers were indispensable in community empowerment, especially in encouraging environmental improvement to remain sustainable for the community's prosperity.