bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Evaluation Of Dermatological Emergency Consultations In The Coronavirus Pandemic Era: Tertiary Clinic Experience
Authors: Temel Berkay , Orenay Ozge Mine , Karaosmanoglu Nermin 
Published: February 2023

Introduction: Due to the increase in COVID-19 patients during the pandemic, the workload of emergency departments has increased. The profile of the patients seeking non-COVID medical care has changed significantly because of the pandemic including the dermatological emergencies.
Objective: The aim was to evaluate and compare adult dermatological emergency consultations during the COVID-19 period with pre-pandemic period.
Methods:Consulted patients from ED to dermatology between March 11, 2019, and March 11, 2021 were included (Pre-pandemic and pandemic) Age, gender, zone of triage, consultation hour, consultation date, consultation response time, ICD-10 codes were recorded.
Results: The total number of consultations were 639. The mean age of the patients in the pre-pandemic period was 44.4 and 46.1 in the pandemic period. The mean consultation response time in the pre-pandemic period was 44.4 minutes and 60.3 minutes in the pandemic. In the pre-pandemic period, the most common consulted diseases were herpes zoster, urticaria, and allergic contact dermatitis. In the pandemic, the most common consulted diseases were herpes zoster, dermatitis other, and urticaria.There was a statistically significant difference of the incidence of other dermatitis, impetigo/folliculitis, cutaneous vasculitis, and pruritus (p<0.05)
Conclusions: Emergency departments are the busiest and fastest areas of the hospital. Pandemics such as COVID-19 may also occur in the coming years. Informing the society about dermatological emergencies and adding adequate dermatology training to the training of emergency physicians will facilitate appropriate patient management in emergency departments.
Dermoscopic Findings in Intraepidermal Carcinoma: An Interobserver Agreement Study
Authors: Fougelberg Julia , Luong Alfred , Bowling Jonathan , Chamberlain Alex , Lallas Aimilios , Marghoob Ashfaq , Polesie Sam , Salerni Gabriel , Tanaka Masaru , Zaar Oscar , Zalaudek Iris , Claeson Magdalena , Paoli John 
Published: February 2023

Introduction: A wide range of descriptive terms have been used for dermoscopic findings in intraepidermal carcinoma (IEC) and the clinical diagnostic accuracy of IEC can be challenging. Furthermore, dermoscopic findings in IEC have only rarely been evaluated in fair-skinned populations.
Objectives: To measure the interobserver agreement between dermatologists for dermoscopic findings in IEC. Furthermore, to describe the frequency of these findings in a predominantly fair-skinned population.
Methods: One hundred dermoscopic images of histopathologically verified IECs were collected. The 11 most common dermoscopic findings described in previous studies were re-defined in a new terminology in a pre-study consensus meeting. Images were assessed by eight experienced international dermoscopists. The frequency of findings and the interobserver agreement was analyzed.
Results: Scales (83%), dotted/glomerular vessels (77%), pinkish-white areas (73%) and hemorrhage (46%) were the most commonly present dermoscopic findings. Pigmented structures were found in 32% and shiny white structures (follicular or stromal) in 54% of the IEC. Vascular structures (vessels and/or hemorrhage) could be seen in 89% of the lesions. Overall, the interobserver agreement for the respective dermoscopic findings was poor to moderate, with the highest kappa values noted for scales (0.55) and hemorrhage (0.54) and the lowest for pinkish-white areas (0.015).
Conclusion: Our results confirm those of previous studies on dermoscopy in IEC, including the frequency of pigmented structures despite the fair-skinned population. The interobserver agreement was relatively low. The proposed new terminology and our findings can hopefully serve as a guideline for researchers, teachers and students on how to identify IEC.
Clinical Efficacy Of Medical Dextrose Tincture Liquid In The Treatment Of Facial Photoaging
Authors: Song Yuexing , Liu Qiuhui , Zhang Yihan , Zhang Huina , Li Bin 
Published: February 2023

Objectives: The purpose of this study was to explore the clinical efficacy of medical dextrose tincture liquid (medical dextrose tincture) in the treatment of facial photoaging.
Methods: Thirty-four volunteers were included in the randomized double-blind study. According to the random number table method, the subjects were randomized into control and treatment groups. The subjects in the control and treatment groups were treated with medical hyaluronic acid gel and medical dextrose tincture, respectively. They received three times of mesotherapy therapy with an interval of 28 days. Video image acquisition was performed before treatment and 28 days after treatment. Skin moisture content, glossiness, heme content, collagen density, and elasticity were tested. The subjective evaluation of subjects and doctors before and after treatment were compared.
Results: Compared with before treatment, medical dextran tincture significantly increased the skin moisture retention, skin gloss, and skin collagen density (p<0.001). Additionally, the skin retraction time was significantly reduced, and the skin retraction time was also markedly decreased after treatment with medical dextran tincture (p<0.001). The effects of medical dextran tincture were more significant in comparison with medical hyaluronic acid gel (p<0.05). The subjective evaluation results of doctors showed that after 84 days of treatment, the overall skin photoaging score was significantly reduced (p<0.001). The subjective evaluation results of volunteers showed that the various skin problems of more than 50% of volunteers were improved after treatment.
Conclusion: Medical dextran tincture has obvious effects of moisturizing, increasing luster, improving skin redness, increasing skin collagen content and enhancing skin elasticity.
The Psychosocial Impact of Chronic Facial Dermatoses in Adults
Authors: Ozcan Yunus , Sungur Mehmet Ali , Yaman Özcan Begüm , Eyüp Yavuz , Özlü Emin 
Published: February 2023

Introduction: Skin diseases have negative psychological and social consequences, especially when they are chronic and affect a visible area of the body, such as the face.
Objectives: The purpose of this study is to investigate and compare the psychosocial impact of three common chronic dermatoses of the face: acne, rosacea, and seborrheic dermatitis.
Methods: The Dermatology Life Quality Index (DLQI), Hospital Anxiety and Depression Scale (HADS), and Social Appearance Anxiety Scale (SAAS) were used to compare acne, rosacea, and seborrheic dermatitis patients and healthy controls. The relationships between DLQI, HADS, and SAAS results were investigated, as well as their associations with disease duration and severity.
Results: The study included 164 acne patients, 134 rosacea patients, 120 seborrheic dermatitis patients, and 124 controls. The patient groups had significantly higher DLQI, HADS, and SAAS scores than the control group. Rosacea patients had the highest DLQI and SAAS scores, as well as the highest anxiety prevalence. Patients with seborrheic dermatitis had the highest rate of depression. The DLQI, HADS, and SAAS results were moderately correlated with each other, but their relationship with disease duration and severity was insignificant or weak at best.
Conclusions: Chronic facial dermatoses have a detrimental impact on mood and quality of life. Although patients with acne, rosacea, and seborrheic dermatitis have distinct lesions, the outcomes in terms of quality of life, anxiety, and depression are largely similar. Furthermore, these patients have a higher prevalence of social anxiety as a result of their overall appearance rather than just their faces.
Diagnosis and differential diagnosis of Poikiloderma of Civatte: a Dermoscopy Cohort Study
Authors: Katoulis Alexander , Sgouros Dimitrios , Bozi Evangelia , Pappa Georgia , Theotokoglou Sofia , Konstantinou Marie Pauline , Voudouri Alexandra , Voudouri Maria , Theofili Melpomeni , Tzima Korina , Hofmann-Wellenhof Rainer 
Published: February 2023

Introduction: Poikiloderma of Civatte (PC) is a common, acquired, chronic, benign poikiloderma of the neck and face, most commonly affecting menopausal females. Until the day of writing, few have been published regarding dermoscopy of PC.
Objective: To describe the dermoscopic picture of PC, so as to provide a clinico-dermoscopic diagnosis and differential diagnosis for PC.
Methods: Twenty-eight patients with PC, aged 26-73 years, of whom 19 females (67.86%) were evaluated by detailed history, clinical examination, and dermoscopic examination with hand-held dermatoscope.
Results: The reticular pattern was observed in 15 cases (53.6%); the white dot in 10 (35.7%); the non-specific in 9 (32.1%); and the spaghetti and meatballs-like in 8 (28.6%). Regarding local dermoscopic features, flying seagull-like vessels were observed in 18 cases (64.3%); linear irregular vessels in 17 (60.7%); rhomboidal/polygonal vessels in 15 (53.6%); dotted/globular vessels in 10 (35.7%); white macules in 23 (82.1%); brown macules in 11 (39.3%); and whitish follicular plugs in 6 (21.4%).
Conclusions: The dermoscopic picture of PC is highly characteristic and corresponds well to both clinical and histological findings. Dermoscopy may assist clinical diagnosis, as well as the differentiation from other dermatoses of the neck and face, especially poikilodermas with guarded prognosis.
Mortality Of Malignant Melanoma In Central Serbia, In The Period 1999-2015
Authors: Pantovic Milica , Djordjevic Ognjen , Radevic Svetlana , Bankovic Dragic , Parezanovic Ilic Katarina , Radovanovic Snezana 
Published: February 2023

Introduction: Malignant melanoma is one of the rarest but the most deadly form of skin cancer.
Objective: The objective of this paper was to analyze the epidemiological characteristics and trends of mortality from malignant melanoma of the population of Central Serbia in the period 1999-2015.
Methods: The study was designed as a retrospective descriptive epidemiological study. Standardized mortality rates were used in statistical data processing. A linear trend model and regression analysis were used to examine trends in malignant melanoma mortality.
Results: In Serbia, malignant melanoma mortality shows an increasing trend. The overall age-adjusted melanoma death rate was 2.6 per 100 000 with a higher death rate among men (3.03per 100 000) than among women (2.1 per 100 000). Malignant melanoma mortality rates increase with age in both sexes and are highest in the age group of 75 and older. The highest increase in mortality in men is recorded in the age group of 65-69 years, with an average percentage increase of 21.33 (95% CI, 8.40 - 51.05), while in women the largest increase in mortality was recorded in the age group 35-39 years, with an average percentage increase of 31.4 and in the age group of 70-74 years, 12.9 .
Conclusions: The trend of increasing mortality from malignant melanoma in Serbia is similar to those in most developed countries. Education and improvement of the awareness of the general population and among health professionals remain vital to reducing melanoma mortality in the future.
Bowel Preparation in Pediatric Colorectal Surgery, Can We Move On? Historical and Literature Review
Authors: Rinaldhy Kshetra , Wisnu Ganesha , Widyani Ni Made Sarastri , Yani Ahmad 
Published: February 2023

Background: Surgical procedure in colorectal cases have a high morbidity rate; in pediatric population, surgical site infection occurs in more than 13% of patients undergoing elective colorectal surgery. Bowel preparation is believed to decrease infection rate by removing feces from colorectal. This procedure has been routinely performed despite the lack of clear evidence and the invasive nature of the procedure. In pediatric population, the evidence is scarce with varying qualities, thus this study aims to evaluate the effect of bowel preparation on pediatric population.
Methods: We conducted a comprehensive literature review from PubMed and cross-referencing articles. Six full-text studies presenting bowel preparation in pediatric colorectal surgeries were included in the analysis.
Results: Majority of studies we analyzed showed no association between bowel preparation and surgical site infections. They also showed the lack of correlation between the procedure and post-operative complication.
Discussion: Bowel preparation was quickly adapted by surgeons due to its theoretical effect, but current evidence showed no clear benefit in doing so. In pediatric cases, the evidence is scarce and variable, and with the risk associated, surgeons should consider carefully before conducting bowel preparation in pediatric patients.
Conclusion: Bowel preparation does not significantly decrease post-operative morbidities, such as anastomosis leakage, intrabdominal infection, and surgical wound infection.
Early Clinical Experience with the Use of a New Allograft Adipose Matrix for Foot Fat Pad Restoration
Authors: Gold Jodi Schoenhaus 
Published: February 2023

Background: Fat pad atrophy is the loss of subcutaneous tissue in the plantar foot, inhibiting the cushioning function. Patients experience severe pain on ambulation from high-pressure forces. Soft-tissue augmentation, or fat pad restoration, is performed to improve the thickness and cushioning ability of the subcutaneous layer. The first of its kind, allograft adipose matrix (AAM), which has been reported to support native fat pad restoration, was evaluated to address fat pad atrophy and the cushioning ability in the plantar foot.
Methods: An institutional review board–approved retrospective study review and analysis of 16 patients (21 feet) treated with AAM in the plantar foot was conducted. Adverse events and a subjective patient evaluation of percentage improvement were reported, sometimes supported by imaging.
Results: The mean ± SD volume of AAM injected was 2.2 ± 0.7 mL (range, 1.5–2.6 mL), with a follow-up time of 3 to 20 months, in patients with a mean ± SD age of 68.6 ± 8.9 years. Overall minimal adverse events were observed, and the mean ± SD percentage improvement, as per patient feedback, was 72.9% ± 23.0% (100% corresponds to fully satisfied). The quality of skin improved with reduced presence of callus, and patients resumed their daily activities.
Conclusions: An AAM can support endogenous fat pad restoration by supplementing fat thickness and its natural cushioning ability. The early clinical observations in this retrospective study review demonstrated that patients could resume daily activities after treatment.
Relationship Between Hallux Valgus Interphalangeal Deformity and the Recurrence of Ingrown Toenail in Children
Authors: Tasatan Ersin , Tekin Esra Akdas 
Published: February 2023

Background: An abnormal hallux interphalangeal angle may be an important risk factor for the recurrence of ingrown toenails.
Methods: Sixty pediatric patients who underwent surgery for an ingrown toenail were evaluated retrospectively in terms of recurrence. The patients were divided into two groups. Group 1 included 30 patients (22 boys and eight girls) with hallux valgus interphalangeal deformity. Group 2 included 30 patients (20 boys and ten girls) without toe deformity.
Results: The mean ± SD patient age was 12.8 ± 1.42 years and 12.5 ± 1.45 years in groups 1 and 2, respectively. There was no significant difference between the patient and control groups in terms of age and sex (P > .05). The mean ± SD follow-up time was 30.2 ± 13.46 months in group 1 and 31.3 ± 12.86 months in group 2 (P = .286). We observed recurrence in six patients (20%) in group 1 and in two patients (6.7%) in group 2.
Conclusions: The recurrence of an ingrown toenail may be associated with an increased hallux interphalangeal angle in pediatric patients. Factors related to the hallux interphalangeal angle abnormality, which increases the risk of ingrown toenails, also increase the recurrence rate in these patients. Therefore, it is surmised that hallux valgus interphalangeal deformity should be evaluated before surgery, and patients and their families should be informed about the increased risk of recurrence.
Antioxidant Activity-Guided Isolation of Phenolic Compounds from Leaves of Vitex pinnata (Lamiaceae)
Authors: Faisal Hudia Umami , Efdi Mai , Itam Afrizal , Okselni Tia , Anwar Lenny 
Published: February 2023

The aim of this study is to isolate phenolic compounds from the ethyl acetate fraction of the leaves of V. pinnata Linn, which have antioxidant properties, guided by a TLC-Bioautography (Thin-layer chromatography) with a reagent of 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). The TLC-antioxidant bioautography technique has several advantages. It does not require a long time in testing, the sample used is small, and it can potentially obtain promising antioxidant-positive compounds.The isolation process led to obtaining two phenolic compounds. The UV-Vis, FTIR, and NMR spectrum analysis showed that the compounds were (1) p-hydroxybenzoate and (2) luteolin. Further antioxidant evaluation by DPPH assay showed a potential radical scavenging DPPH of luteolin (2) with an IC50 of 1.56±0.18 µg/mL.
Association of Resident Independence With Short-term Clinical Outcome in Core General Surgery Procedures
Authors: Tonelli Celsa M. , Cohn Tyler , Abdelsattar Zaid , Luchette Frederick A. , Baker Marshall S. 
Published: February 2023

ImportancePrior studies evaluating the effect of resident independence on operative outcome draw from case mixes that cross disciplines and overrepresent cases with low complexity. The association between resident independence and clinical outcome in core general surgical procedures is not well defined.ObjectiveTo evaluate the level of autonomy provided to residents during their training, trends in resident independence over time, and the association between resident independence in the operating room and clinical outcome.Design, Setting, and ParticipantsUsing the Veterans Affairs Surgical Quality Improvement Program database from 2005 to 2021, outcomes in resident autonomy were compared using multivariable logistic regression and propensity score matching. Data on patients undergoing appendectomy, cholecystectomy, partial colectomy, inguinal hernia, and small-bowel resection in a procedure with a resident physician involved were included.ExposuresResident independence was graded as the attending surgeon scrubbed into the operation (AS) or the attending surgeon did not scrub (ANS).Main Outcomes and MeasuresOutcomes of interest included rates of postoperative complication, severity of complications, and death.ResultsOf 109 707 patients who met inclusion criteria, 11 181 (10%) underwent operations completed with ANS (mean [SD] age of patients, 61 [14] years; 10 527 [94%] male) and 98 526 (90%) operations completed with AS (mean [SD] age of patients, 63 [13] years; 93 081 [94%] male). Appendectomy (1112 [17%]), cholecystectomy (3185 [11%]), and inguinal hernia (5412 [13%]) were more often performed with ANS than small-bowel resection (527 [6%]) and colectomy (945 [4%]). On multivariable logistic regression adjusting for procedure type, age, body mass index, functional status, comorbidities, American Society of Anesthesiologists class, wound class, case priority, admission status, facility type, and year, factors associated with a complication included increasing age (adjusted odds ratio [aOR], 1.19 [95% CI, 1.16-1.22]), emergent case priority (aOR, 1.41 [95% CI, 1.33-1.50]), and resident independence (aOR, 1.12 [95% CI, 1.03-1.22]). On propensity score matching, AS cases were score matched 1:1 to ANS cases based on the variables listed above. Comparing matched cohorts, there was no difference in complication rates (817 [7%] vs 784 [7%]) or death (91 [1%] vs 102 [1%]) based on attending physician involvement.Conclusions and RelevanceCore general surgery cases performed by senior-level trainees in such a way that the attending physician is not scrubbed into the case are being done safely with no significant difference in rates of postoperative complication.
Effect of Focal vs Extended Irreversible Electroporation for the Ablation of Localized Low- or Intermediate-Risk Prostate Cancer on Early Oncological Control
Authors: Zhang Kai , Teoh Jeremy , Laguna Pilar , Dominguez-Escrig Jose , Barret Eric , Ramon-Borja Juan Casanova , Muir Gordon , Bohr Julia , de Reijke Theo M. , Pelechano Gómez Paula , Ng Chi-Fai , Sanchez-Salas Rafael , de la Rosette Jean 
Published: February 2023

ImportanceFocal ablative irreversible electroporation (IRE) is a therapy that treats only the area of the tumor with the aim of achieving oncological control while reducing treatment-related functional detriment.ObjectiveTo evaluate the effect of focal vs extended IRE on early oncological control for patients with localized low- and intermediate-risk prostate cancer.Design, Setting, and ParticipantsIn this randomized clinical trial conducted at 5 centers in Europe, men with localized low- to intermediate-risk prostate cancer were randomized to receive either focal or extended IRE ablation. Data were collected at baseline and at regular intervals after the procedure from June 2015 to January 2020, and data were analyzed from September 2021 to July 2022.Main Outcomes and MeasuresOncological outcome as indicated by presence of clinically significant prostate cancer (International Society of Urological Pathology grade ≥2) on transperineal template-mapping prostate biopsy at 6 months after IRE. Descriptive measures of results from that biopsy included the number and location of positive cores.ResultsA total of 51 and 55 patients underwent focal and extended IRE, respectively. Median (IQR) age was 64 years (58-67) in the focal ablation group and 64 years (57-68) in the extended ablation group. Median (IQR) follow-up time was 30 months (24-48). Clinically significant prostate cancer was detected in 9 patients (18.8%) in the focal ablation group and 7 patients (13.2%) in the extended ablation group. There was no significant difference in presence of clinically significant prostate cancer between the 2 groups. In the focal ablation group, 17 patients (35.4%) had positive cores outside of the treated area, 3 patients (6.3%) had positive cores in the treated area, and 5 patients (10.4%) had positive cores both in and outside of the treated area. In the extended group, 10 patients (18.9%) had positive cores outside of the treated area, 9 patients (17.0%) had positive cores in the treated area, and 2 patients (3.8%) had positive cores both in and outside of the treated area. Clinically significant cancer was found in the treated area in 5 of 48 patients (10.4%) in the focal ablation group and 5 of 53 patients (9.4%) in the extended ablation group.Conclusions and RelevanceThis study found that focal and extended IRE ablation achieved similar oncological outcomes in men with localized low- or intermediate-risk prostate cancer. Because some patients with intermediate-risk prostate cancer are still candidates for active surveillance, focal therapy may be a promising option for those patients with a high risk of cancer progression.Trial RegistrationClinicalTrials.gov Identifier: NCT01835977