bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying the prognostic significance of early arrhythmia recurrence during the blanking period and the optimal blanking period duration: insights from the DECAAF II study
Authors: Noujaim Charbel , Lim Chanho , Mekhael Mario , Feng Han , Chouman Nour , Younes Hadi , Assaf Ala , Shan Botao , Shamaileh Ghaith , Dhore-Patil Aneesh , Nelson Daniel , Lanier Brennan , Makan Noor , Marrouche Nassir , Donnellan Eoin 
Published: June 2023

Abstract

Objective
Early atrial arrhythmia recurrence following atrial fibrillation (AF) ablation is common. Current guidelines promulgate a 3-month blanking period. We hypothesize that early atrial arrhythmia recurrence during the blanking period may predict longer-term ablation outcomes.

Methods and results
A total of 688 patients with persistent AF undergoing catheter ablation were included in the DECAAF II trial database. The primary endpoint of the study was the first confirmed recurrence of atrial arrhythmia. Recurrence was also monitored during the 90-day blanking period. A total of 287 patients experienced recurrent atrial arrhythmia during the blanking period, while 401 remained in sinus rhythm. Rates of longer-term arrhythmia recurrence were substantially higher among those who developed recurrence during the blanking period compared to those who remained in sinus rhythm throughout the blanking period (68% vs. 32%, P &lt; 0.001). The study cohort was divided into three groups according to the timing of arrhythmia recurrence during the blanking period. Of those who had recurrent arrhythmia during the first month of the blanking period (Group 1), 43.9% experienced longer-term recurrence, compared to 61.6% who recurred during the second month of the blanking period (Group 2), and 93.3% of those who had arrhythmia recurrence during the third month (Group 3, P &lt; 0.001). The risk of recurrent arrhythmia was highest in Group 3 (HR = 10.15), followed by Group 2 (HR = 2.35) and Group 1 (HR = 1.5). Receiver operating characteristic analysis was performed to assess the relationship between the timing of arrhythmia recurrence and the primary outcome (AUC = 0.746, P &lt; 0.001). The optimal blanking period duration was identified as 34 days. Atrial fibrillation burden determined by smartphone electrocardiogram technology over the 18 months follow-up period was significantly higher in Group 3 (29%) compared to Groups 1 (6%) and 2 (7%) and in patients who stayed in sinus rhythm during the blanking period (5%) (P &lt; 0.0001).

Conclusion
Early atrial arrhythmia recurrence during the blanking period, particularly during the third month, is significantly associated with later recurrence. Although a blanking period is warranted, it should be abbreviated.
The non-use of evidence in the adoption of a sugar-sweetened beverage tax in OECD countries
Authors: Hornung Johanna , Sager Fritz 
Published: June 2023

Abstract

Background
Studies confirm the positive effect of sugar-sweetened beverage (SSB) taxation on public health. However, only a few countries in Europe adopt SSB taxes. From a public policy perspective, we investigate the conditions under which countries do or do not follow this evidence.

Methods
Crisp-set Qualitative Comparative Analysis (QCA) of 26 European Organization of Economic Cooperation and Development countries with and without an SSB tax. We test which configurations of conditions (problem pressure, governmental composition, strategic planning, health care system, public health policies, inclusion of expert advice in policymaking) emerge as relevant in determining adoption and non-adoption between the years 1981 and 2021. Pathways that lead to the presence and absence of SSB taxes are identified separately.

Results
At least one of the following configurations of conditions is present in countries that introduced taxation: (i) high financial problem pressure, low regulatory impact assessment activity; (ii) high public health problem pressure, a contribution-financed health care system, no holistic strategy for combatting non-communicable diseases (NCDs); (iii) a tax-financed health care system, a holistic NCD strategy, high strategic and executive planning capacity. In countries that did not adopt SSB taxes, we find (i) high regulatory impact assessment activity, high levels of sugar export; (ii) no holistic NCD strategy, high spending on preventive care; (iii and iv) a lack of strategic planning capacity and either a high share of spending on preventive care or inclusion of expert advice.

Discussion
Evidence inclusion requires clear policy priorities in terms of strategy and resources to promote public health.
An investigation of the sex-specific genetic architecture of fitness in Drosophila melanogaster
Authors: Singh Amardeep , Hasan Asad , Agrawal Aneil F 
Published: June 2023

Abstract
In dioecious populations, the sexes employ divergent reproductive strategies to maximize fitness and, as a result, genetic variants can affect fitness differently in males and females. Moreover, recent studies have highlighted an important role of the mating environment in shaping the strength and direction of sex-specific selection. Here, we measure adult fitness for each sex of 357 lines from the Drosophila Synthetic Population Resource in two different mating environments. We analyze the data using three different approaches to gain insight into the sex-specific genetic architecture for fitness: classical quantitative genetics, genomic associations, and a mutational burden approach. The quantitative genetics analysis finds that on average segregating genetic variation in this population has concordant fitness effects both across the sexes and across mating environments. We do not find specific genomic regions with strong associations with either sexually antagonistic (SA) or sexually concordant (SC) fitness effects, yet there is modest evidence of an excess of genomic regions with weak associations, with both SA and SC fitness effects. Our examination of mutational burden indicates stronger selection against indels and loss-of-function variants in females than in males.
Chromosome-Level Assemblies of the Pieris mannii Butterfly Genome Suggest Z-Origin and Rapid Evolution of the W Chromosome
Authors: Berner Daniel , Ruffener Simona , Blattner Lucas A 
Published: June 2023

Abstract
The insect order Lepidoptera (butterflies and moths) represents the largest group of organisms with ZW/ZZ sex determination. While the origin of the Z chromosome predates the evolution of the Lepidoptera, the W chromosomes are considered younger, but their origin is debated. To shed light on the origin of the lepidopteran W, we here produce chromosome-level genome assemblies for the butterfly Pieris mannii and compare the sex chromosomes within and between P. mannii and its sister species Pieris rapae. Our analyses clearly indicate a common origin of the W chromosomes of the two Pieris species and reveal similarity between the Z and W in chromosome sequence and structure. This supports the view that the W in these species originates from Z–autosome fusion rather than from a redundant B chromosome. We further demonstrate the extremely rapid evolution of the W relative to the other chromosomes and argue that this may preclude reliable conclusions about the origins of W chromosomes based on comparisons among distantly related Lepidoptera. Finally, we find that sequence similarity between the Z and W chromosomes is greatest toward the chromosome ends, perhaps reflecting selection for the maintenance of recognition sites essential to chromosome segregation. Our study highlights the utility of long-read sequencing technology for illuminating chromosome evolution.
Locating the Material: Prussian Carved Ambers, Place Ambiguity and a New Geography of Central European Art
Authors: Grusiecki Tomasz 
Published: June 2023

Abstract
No material is linked more closely to early modern Prussia than amber, and both the Hohenzollerns (rulers of Brandenburg-Prussia) and the Vasas (overlords of Royal Prussia) used it extensively for diplomatic gifts, linking this prized material to their territories. Amber was also one of the most enigmatic materials of the period, with its alchemical nature often examined by natural philosophers who sought to determine its origins and physical makeup. Prussian artisans participated in these explorations by foregrounding amber’s metamorphic qualities. Many amber artefacts carved in Königsberg and Danzig self-reflectively depict the transformation of the Heliades, the daughters of the Sun, into poplar trees, an Ovidian trope important for the understanding of amber as a material that was once something else. This article explores how the physical properties of cups, caskets and altarpieces carved in amber had consequences for how these objects were used and activated as a vehicle of elite sociability. By tapping into natural-philosophical treatises, descriptions of places, gift records and poetry, it proposes that amber’s material rhetoric was twofold: (1) to frame the geographically peripheral Prussia as a centre of cultural activity and material exploration, and (2) to encourage the perception of amber-made artefacts as multivalent media capable of evoking multiple geographic locations. It thus delves into the transcultural implications of amber, a Prussian material that simultaneously publicized and obfuscated its origins.
Coseismic drop of seismic velocity caused by the 2023 Turkey–Syria earthquakes
Authors: Müller J , van Laaten M , Eulenfeld T , Wegler U 
Published: June 2023

SUMMARY
The Mw 7.8 earthquake in Turkey on 6 February 2023 was extraordinary for various reasons. It originated in depth of only 10 km, ruptured along a fault plane around 300 km long and the surface was covered by an extensive network of high-quality seismic instruments. The strong motions resulted in a vast number of tragic casualties and huge material losses in Turkey and Syria. However, abundant and proximate seismic observations of this event and numerous aftershocks give an opportunity to deepen the understanding of earthquake processes. In this study, we carried out an assessment of coseismic changes of seismic velocity using passive image interferometry. We used data from one strong-motion and twenty-four broad-band sensors. We observed coseismic drops of seismic velocity, which reached up to −1.79 per cent at a location directly at the ruptured East Anatolian Fault Zone. Along the Mw 7.8 earthquake fault, we observe frequency dependence of the velocity changes. At frequencies above 0.5 Hz, the velocity drops seem to be higher at locations close to the ruptured faults than in the more distant areas.
Using evidence in mental health policy agenda-setting in low- and middle-income countries: a conceptual meta-framework from a scoping umbrella review
Authors: Brooks Chloe , Mirzoev Tolib , Chowdhury Diptarup , Deuri Sonia Pereira , Madill Anna 
Published: June 2023

Abstract
The purpose of this article is to close the gap in frameworks for the use of evidence in the mental health policy agenda-setting in low- and middle-income countries (LMICs). Agenda-setting is important because mental health remains a culturally sensitive and neglected issue in LMICs. Moreover, effective evidence-informed agenda-setting can help achieve, and sustain, the status of mental health as a policy priority in these low-resource contexts. A scoping ‘review of reviews’ of evidence-to-policy frameworks was conducted, which followed preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Nineteen reviews met the inclusion criteria. A meta-framework was developed from analysis and narrative synthesis of these 19 reviews, which integrates the key elements identified across studies. It comprises the concepts of evidence, actors, process, context and approach, which are linked via the cross-cutting dimensions of beliefs, values and interests; capacity; power and politics; and trust and relationships. Five accompanying questions act as a guide for applying the meta-framework with relevance to mental health agenda-setting in LMICs. This is a novel and integrative meta-framework for mental health policy agenda-setting in LMICs and, as such, an important contribution to this under-researched area. Two major recommendations are identified from the development of the framework to enhance its implementation. First, given the paucity of formal evidence on mental health in LMICs, informal evidence based on stakeholder experience could be better utilized in these contexts. Second, the use of evidence in mental health agenda-setting in LMICs would be enhanced by involving a broader range of stakeholders in generating, communicating and promoting relevant information.
Uterus transplantation: from research, through human trials and into the future
Authors: Brännström Mats , Racowsky Catherine , Carbonnel Marie , Wu Joseph , Gargiulo Antonio , Adashi Eli Y , Ayoubi Jean Marc 
Published: June 2023

AbstractWomen suffering from absolute uterine factor infertility (AUFI) had no hope of childbearing until clinical feasibility of uterus transplantation (UTx) was documented in 2014 with the birth of a healthy baby. This landmark accomplishment followed extensive foundational work with a wide range of animal species including higher primates. In the present review, we provide a summary of the animal research and describe the results of cases and clinical trials on UTx. Surgical advances for graft removal from live donors and transplantation to recipients are improving, with a recent trend away from laparotomy to robotic approaches, although challenges persist regarding optimum immunosuppressive therapies and tests for graft rejection. Because UTx does not involve transplantation of the Fallopian tubes, IVF is required as part of the UTx process. We provide a unique focus on the intersection between these two processes, with consideration of when oocyte retrieval should be performed, whether, and for whom, preimplantation genetic testing for aneuploidy should be used, whether oocytes or embryos should be frozen and when the first embryo transfer should be performed post-UTx. We also address the utility of an international society UTx (ISUTx) registry for assessing overall UTx success rates, complications, and live births. The long-term health outcomes of all parties involved—the uterus donor (if live donor), the recipient, her partner and any children born from the transplanted graft—are also reviewed. Unlike traditional solid organ transplantation procedures, UTx is not lifesaving, but is life-giving, although as with traditional types of transplantation, costs, and ethical considerations are inevitable. We discuss the likelihood that costs will decrease as efficiency and efficacy improve, and that ethical complexities for and against acceptability of the procedure sharpen the distinctions between genetic, gestational, and social parenthood. As more programs wish to offer the procedure, we suggest a scheme for setting up a UTx program as well as future directions of this rapidly evolving field. In our 2010 review, we described the future of clinical UTx based on development of the procedure in animal models. This Grand Theme Review offers a closing loop to this previous review of more than a decade ago. The clinical feasibility of UTx has now been proved. Advancements include widening the criteria for acceptance of donors and recipients, improving surgery, shortening time to pregnancy, and improving post-UTx management. Together, these improvements catalyze the transition of UTx from experimental into mainstream clinical practice. The procedure will then represent a realistic and accessible alternative to gestational surrogacy for the treatment of AUFI and should become part of the armamentarium of reproductive specialists worldwide.
Associations of meal timing, number of eating occasions and night-time fasting duration with incidence of type 2 diabetes in the NutriNet-Santé cohort
Authors: Palomar-Cros Anna , Srour Bernard , Andreeva Valentina A , Fezeu Léopold K , Bellicha Alice , Kesse-Guyot Emmanuelle , Hercberg Serge , Romaguera Dora , Kogevinas Manolis , Touvier Mathilde 
Published: June 2023

Abstract

Background
Food intake plays a pivotal role in regulating circadian rhythms, which modulate glucose and lipid homeostasis. However, studies investigating the association of meal timing and type 2 diabetes (T2D) incidence are lacking. The objective of this study was to investigate the longitudinal associations of meal timing, number of eating occasions and night-time fasting duration with incidence of T2D.

Methods
In total, 103 312 adults [79% women, mean age at baseline = 42.7 (SD = 14.6)] from the NutriNet-Santé cohort (2009–21) were included. Participants’ meal timings and frequency were assessed using repeated 24-h dietary records and averaged from the first 2 years of follow-up (5.7 records/participant). Associations of meal timing, number of eating occasions and night-time fasting duration with incidence of T2D were assessed by using multivariable Cox proportional hazard models adjusted for known risk factors.

Results
During a median follow-up of 7.3 years, 963 new cases of T2D were ascertained. Compared with participants habitually having a first meal before 8AM, those eating after 9AM had a higher incidence of T2D (HR = 1.59, 95% CI 1.30–1.94). Time of last meal was not associated with T2D incidence. Each additional eating episode was associated with a lower incidence of T2D (HR = 0.95, 95% CI 0.90–0.99). Night-time fasting duration was not associated with T2D incidence, except in participants having breakfast before 8AM and fasting for &gt;13 h overnight (HR = 0.47, 95% CI 0.27–0.82).

Conclusions
In this large prospective study, a later first meal was associated with a higher incidence of T2D. If confirmed in other large-scale studies, an early breakfast should be considered in preventing T2D.
Potential measurement of electricity supply
Authors: Jahangiri Mehdi , Khorsand Dehkordi Mohammad , Khorsand Dehkordi Sahar 
Published: June 2023

Abstract
Hydrogen has a therapeutic effect in a wide range of diseases and its presence in medical centers is essential. Hydrogen can increase efficiency along with renewable energy systems (green hydrogen). Due to the importance of the above, in the present work for the first time, the feasibility of hydrogen production on a hospital scale using water electrolysis by wind, solar and biomass energies has been investigated. The aim of the present work is to supply renewable electricity to four hospital hydrogen generators of MD-H2 400 model. Technical-economic-environmental-energy analyses were performed by HOMER 2.81 software and the study site is Shahrekord, the capital of Chaharmahal and Bakhtiari province. The results showed that the lowest cost per kWh of electricity generated for a system disconnected from the grid with a value of $0.251 related to the system including 8 kW solar cell, 1 kW diesel generator, 9 batteries and 2 kW electric converter that the effect of temperature on performance solar cells is included. For this superior scenario, 154 kg of CO2 emissions is generated annually because 3% of the required electricity is supplied by a diesel generator. Another point that can be seen from the results is that not considering the temperature in the performance of solar cells in the study area causes some errors in the calculations and increases the levelized cost of energy parameter. This issue has not been considered in many past works and the current work in this field has an advantage.
Genetic Profiling of Plasmodium ovale wallikeri Relapses With Microsatellite Markers and Whole-Genome Sequencing
Authors: Joste Valentin , Colard-Itté Emma , Guillochon Émilie , Ariey Frédéric , Coppée Romain , Clain Jérôme , Houzé Sandrine ,   for the French National Reference Center for Imported Malaria Study Group, Aboubacar Ahmed , Angebault Cécile , Angoulvant Adela , Argy Nicolas , Azjenberg Daniel , Belkadi Ghania , Bellanger Anne-Pauline , Bemba Dieudonné , Blaize Marion , Botterel Françoise , Bougnoux Marie-Elisabeth , Brun Sophie , Buret Bernadette , Chevrier Sylviane , Clauser Sylvain , Dahane Naima , Dannaoui Eric , Dard Céline , Dardé Marie-Laure , de Gentile Ludovic , de Suremain Nathalie , Debourgogne Anne , Delaval Anne , Deleplancque Anne-Sophie , Desoubeaux Guillaume , Durand Rémy , Durieux Marie-Fleur , Dutoit Emmanuel , Eloy Odile , Fenneteau Odile , Gargala Gilles , Godineau Nadine , Guennouni Nadia , Guinard Jérôme , Hamane Samia , Herault Etienne , Larreché Sébastien , Lavergne Rose-Anne , Marteau Anthony , Mazars Edith , Moreno-Sabater Alicia , Morio Florent , Nourrisson Céline , Perraud-Cateau Estelle , Pons Denis , Pull Lauren , Quinio Dorothée , Raffenot Didier , Silva Muriel , Thellier Marc , Tielli Alexandra , Toubas Dominique 
Published: June 2023

Abstract
Like Plasmodium vivax, both Plasmodium ovale curtisi and Plasmodium ovale wallikeri have the ability to cause relapse in humans, defined as recurring asexual parasitemia originating from liver-dormant forms subsequent to a primary infection. Here, we investigated relapse patterns in P ovale wallikeri infections from a cohort of travelers who were exposed to the parasite in sub-Saharan Africa and then experienced relapses after their return to France. Using a novel set of 8 highly polymorphic microsatellite markers, we genotyped 15 P ovale wallikeri relapses. For most relapses, the paired primary and relapse infections were highly genetically related (with 12 being homologous), an observation that was confirmed by whole-genome sequencing for the 4 relapses we further studied. This is, to our knowledge, the first genetic evidence of relapses in P ovale spp.
Removing the roadblocks to promoting health equity: finding the social determinants of health addressed in standardized nursing classifications
Authors: Wagner Cheryl Marie , Jensen Gwenneth A , Lopes Camila Takáo , Mcmullan Moreno Elspeth Adriana , Deboer Erica , Dunn Lopez Karen 
Published: June 2023

Abstract
Providing 80% of healthcare worldwide, nurses focus on physiologic and psychosocial aspects of health, which incorporate social determinants of health (SDOH). Recognizing their important role in SDOH, nurse informatics scholars included standardized measurable terms that identify and treat issues with SDOH in their classification systems, which have been readily available for over 5 decades. In this Perspective, we assert these currently underutilized nursing classifications would add value to health outcomes and healthcare, and to the goal of decreasing disparities. To illustrate this, we mapped 3 rigorously developed and linked classifications: NANDA International (NANDA-I), Nursing Interventions Classification (NIC), and Nursing Outcomes Classification (NOC) called NNN (NANDA-I, NIC, NOC), to 5 Healthy People 2030 SDOH domains/objectives, revealing the comprehensiveness, usefulness, and value of these classifications. We found that all domains/objectives were addressed and NNN terms often mapped to multiple domains/objectives. Since SDOH, corresponding interventions and measurable outcomes are easily found in standardized nursing classifications (SNCs), more incorporation of SNCs into electronic health records should be occurring, and projects addressing SDOHs should integrate SNCs like NNN into their ongoing work.