bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dose frequency randomized control trial for Dynamic Temporal and Tactile Cueing (DTTC) treatment for childhood apraxia of speech: Protocol paper
Authors: Iuzzini-Seigel Jenya , Case Julie , Grigos Maria , Velleman Shelley , Thomas Donna , Murray Elizabeth 
Published: January 2023

Abstract
Background
Childhood apraxia of speech (CAS) is a pediatric motor-based speech sound disorder that requires a specialized approach to intervention. The extant literature on the treatment of CAS commonly recommends intensive treatment using a motor-based approach, with some of the best evidence supporting the use of Dynamic Temporal and Tactile Cueing (DTTC). To date, a rigorous and systematic comparison of high and low dose frequency has not been undertaken for DTTC, resulting in a lack of evidence to guide decisions about the optimal treatment schedule for this intervention. The current study aims to fill this gap in knowledge by comparing treatment outcomes when dose frequency is varied.
Methods
A randomized controlled trial will be conducted to examine the efficacy of low versus high dose frequency on DTTC treatment outcomes in children with CAS. A target of 60 children, 2;6–7;11 years of age, will be recruited to participate in this study. Treatment will be provided in the community setting by speech-language pathologists who have completed specialized training administering DTTC in a research reliable manner. True randomization with concealed allocation will be used to assign children to either the low or high dose frequency group. Treatment will be administered in 1-hour sessions either 4 times per week over a 6-week period (high dose) or 2 times per week over a 12-week period (low dose). To measure treatment gains, probe data will be collected before treatment, during treatment, and 1 day, 1 week, 4 weeks, and 12 weeks post-treatment. Probe data will consist of customized treated words and a standard set of untreated words to assess generalization of treatment gains. The primary outcome variable will be whole word accuracy, encompassing segmental, phonotactic, and suprasegmental accuracy.
Discussion
This will be the first randomized controlled trial to evaluate dose frequency for DTTC treatment in children with CAS.
Trial Registration:
ClinicalTrials.gov identifier NCT05675306, January 6, 2023.
Post-prandial Analysis of Fluctuations in the Platelet Count and Platelet Activity in Patients with the Familial Chylomicronemia Syndrome
Authors: Larouche Miriam , Brisson Diane , Morissette Marie-Claude , Gaudet Daniel 
Published: January 2023

Abstract
Background: The familial chylomicronemia syndrome (FCS) is an ultra rare disease caused by lipoprotein lipase (LPL) deficiency associated with potentially lethal acute pancreatitis risk. Thrombocytopenia (platelet count < 150,000 x 109/L) has been reported in patients with FCS, treated or not with volanesorsen, a second generation APOC3 anti-sense oligonucleotide. Chylomicrons are the lipoproteins delivering fat after a meal and FCS is thus a post-prandial disease. Platelet count and activity have not been studied post-prandially in FCS.
Objective: To evaluate post-prandial fluctuations in the platelet count (PLC) and platelet activity in FCS.
Methods: PLC, platelet activity and hematologic variables were measured up-to 5 hours after a meal in 6 homozygotes for FCS causing gene variants (HoLPL), 6 heterozygotes for LPL loss-of-function variants (HeLPL) and 7 normolipidemic controls.
Results: Hourly post-prandial PLC was significantly lower in HoLPL than in controls (p< 0.009). Compared to the other groups, the PLC tended to decrease rapidly (in the first hour) post-meal in HoLPL (p=0.03) and remained lower than baseline 5-hour post-meal (p=0.02) whereas it tended to slightly increase in normolipidemic controls (p=0.02). Platelet activity was not affected by the prandial status. In HoLPL, post-prandial fluctuations in the PLC positively correlated with the lymphocyte count (p=0.005) and negatively with neutrophil/lymphocyte ratio (NLR).
Conclusion: The PLC decreases post-prandially in FCS (HoLPL), is not associated with changes in platelet activity and correlates with the NLR, a marker of acute pancreatitis severity.
Advantage of contrast-enhanced ultrasound guided sentinel lymph node biopsy in early-stage breast cancer, one node might be enough: a prospective cohort study.
Authors: Cui Qiuxia , Dai Li , Li Jialu , Shen Yang , Tao Huijiang , Zhou Xiaofeng , Xue Jialei 
Published: January 2023

Abstract
Objective
the purpose of this study is proving the contrast-enhanced ultrasound (CEUS) identified sentinel lymph node (SLN) could accurately represent the axillary nodes status in early-stage breast cancer.
Method
A total of 109 consecutive consenting patients with clinical node negative and T1-2 breast cancer were included in this study. All patients received CEUS to identify SLN before surgery and deploying a guidewire to locate the SLN in those who were CEUS explored successfully. All patients underwent sentinel lymph node biopsy (SLNB), and blue dye was also used to help in tracing sentinel lymph node during the surgery. Whether to perform axillary lymph node dissection (ALND) depends on the intraoperative pathological result of the SLN identified by CEUS (CE-SLN). Comparing the pathological results of the CE-SLN with the remaining dyed SLN and axillary dissection nodes.
Result
4 patients was failed to identify the CE-SLN, the detection rate of the CEUS is 96.3%. Among the 105 successful patients, 18 were CE-SLN positive by intraoperative frozen section, another one with CE-SLN micrometastasis was diagnosed by paraffin section. No additional lymph node metastases were found for all CE-SLN negative patients, the false negative rate of CEUS-guided SLNB is 0%.
Conclusion
For patients with clinical node negative and small tumor burden breast cancer, SLN located by CEUS can accurately represent the status of axillary lymph nodes.
Characteristics of biogas production and synergistic effect of primary sludge and food waste co-digestion
Authors: Rakić Nikola , Šušteršič Vanja , Gordić Dušan , Jovičić Nebojša , Bošković Goran , Bogdanović Ivan 
Published: January 2023

Abstract
Co-digestion implementation in wastewater treatment plants reduces waste output and enhances biogas yield. In this regard, the objective of this research was to determine the optimal ratio of biodegradable waste and sewage sludge for co-digestion process in a city plant in central Serbia. The increase in biogas production was investigated through batch tests while synergistic effects were evaluated by chemical oxygen demand (COD) balance. Analyses were performed in four volume basis ratios (3/1, 1/1, 1/3, 1/0) of primary sludge and food waste with added low food waste: 3.375%, 4.675%, and 5.35%, respectively. The best proportion was found to be 1/3 with the highest biogas production (618.7 ml/g VS added) and the organic removal of 52.8% COD elimination. COD reductions further supported the synergistic impact; specifically, an additional 7.1%, 12.8%, and 17% of COD were converted into biogas during the co-digestions 1, 2, and 3, respectively. The rise in co-substrate concentrations was accompanied by a uniform hydrolysis rate constant, the absence of any lag phase, and a greater biogas generation rate. The amount of biogas produced within co-digestions proves to be equivalent to the volume of biogas acquired from individual substrates and the mass of added COD in co-digestions but inversely proportional to the mass of COD utilized in mono-digestion. Further on, specific biogas productions and COD values in digesters show linear dependence. Finally, the study points out that COD method can be used for developing relatively accurate model for biogas potential estimation in wastewater treatment plants.
Evaluation of Choroidal Thickness and Choroidal Vascularity Index in Patients With Crimean Congo Hemorrhagic Fever
Authors: Konuk Şerife Gülhan , Kılıç Raşit , Yılmaz Emine Türkoğlu , Kaya Fatih 
Published: January 2023

Abstract
Purpose: To compare the choroidal thickness parameters of patients with Crimean-Congo Hemorrhagic Fever (CCHF) and healthy subjects using spectral domain optical coherence tomography (SD-OCT).
Methods: In this study, right eye of 27 cases diagnosed with CCHF and 27 healthy subjects were evaluated. CCHF cases were evaluated after history of tick bite and hospitalization. Choroidal thickness was measured using EDI-OCT. Choroidal thickness was measured at five different points at the subfovea, temporal and nasal quadrants at 1000 μm intervals up to 2000 μm from the fovea. Choroidal vascular index (CVI) was defined as the ratio of luminal area (LA) to total choroidal area (TCA), including the total and 1500 μm center of the macula (CVItotal and CVI1500).
Result: Choroidal thickness in CCHF group was measured thicker in each quadrant than in the control group and the thickness in the subfoveal and nasal quadrants was significantly greater. TCA, stromal area (SA), LA were found to be significantly higher, but no significant difference was found between CVI and CVI1500.
Conclusion: Our findings suggest that the choroidal structure may be affected by CCHF disease.
Debond identification in GFRP strengthened RC beam using surface guided wave mode generated by angle beam transducer
Authors: PANT Udita , BANERJEE Sauvik 
Published: January 2023

Abstract
Debonding failure is one of the most common failure modes for FRP-strengthened RC structures. Thus, the strengthened structure requires regular inspections using an efficient and field-friendly technique. This paper proposes the use of angle beam (wedge) transducers to identify the debonded zone in a GFRP-strengthened RC beam. An experimental study is conducted to investigate the capability of wedge transducers to generate and receive the intended mode in the specimen. The inspection is carried out in longitudinal and transverse directions, both using the wedge and normal contact transducers. The normalised signal amplitude versus the sensor position plot is compared for ‘with wedge’ and ‘without wedge’ cases. It is found that the use of a wedge transducer significantly reduces the signal noise, thus improving the debond detection ability compared to the usage of normal transducers. Further, a three-dimensional finite element model is developed to understand the characteristics of wave propagation in the same beam specimen. The modal characteristics and normalised amplitude of signals captured in the numerical model is found in good agreement with the experimental results. The successful numerical validation paves the way for further parametric studies using the model in future work. As this technique does not involve the permanent installation of sensors, it can prove to be a competent technique for rapid in-situ nondestructive evaluation of FRP-strengthened RC structures.
Bibliometric and visual analysis of global research on premium IOLs from 2000 to 2022
Authors: Li Liangpin , Yuan Liyun , Li Qingyu , Cai Maoyu , Zhou Xueyan , Mao Deshen , Hua Xia , Yuan Xiaoyong 
Published: January 2023

AbstractBackground Premium intraocular lenses (PIOLs), particularly those using multifocal, extended depth of focus (EDoF) and toric technologies, have been in clinical use for decades, giving countless cataract patients the ability to see the world clearly again. To explore the development process, research status and future development trends of PIOLs, we explored research on PIOLs from the past 22 years through bibliometrics. Methods The literature search was performed on the Web of Science and included PIOL studies published between 2000 and November 2022. The retrieved literature was collated and analyzed by R-tool's Bibliometrix package, CitNetExplorer, CiteSpace and other software. Results We obtained a total of 1801 articles about PIOLs, most of which were published in Spain and the United States. The organization that published the most articles was the University of Valencia in Spain. Alió JL, and Montés-Micó R, from Spain were the most influential authors in this field. The Journal of Cataract and Refractive Surgery and Journal of Refractive Surgery were the core journals for this field; the top 10 cited articles mainly focus on postoperative satisfaction with multifocal IOLs and postoperative results of toric IOLs. Through a key word analysis, we found that trifocal IOLs, astigmatism and EDoF IOLs are the most discussed topics at present, and the importance of astigmatism and the clinical application of the new generation of PIOL are the emerging research trends. In addition, we found that researchers are not only focusing on the application of cutting-edge technology but also paying increasing attention to patients' subjective satisfaction. Conclusion Bibliometric analysis can effectively help to identify multilevel concerns in premium intraocular lens (PIOL) research and we found that in the past 2 decades, the research of PIOL has made rapid development and gradually matured, countless cataract patients can regain excellent visual quality and improve their quality of life after surgery. The current research hotspots regarding PIOL are the application of EDoF IOL as well as trifocal IOL and its toric models and the development of new types of PIOLs.
Preoperative diagnosis of pulmonary sarcomatoid carcinoma based on CT findings and radiomics
Authors: Tang Wenjian , Wen Chunju , Pei Yixiu , Wu Zhen , Zhong Junyuan , Peng Jidong , Zhong Jianping 
Published: January 2023

AbstractBackground Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non-small cell lung cancers (NSCLC), but differs in terms of prognosis and treatment strategies. Due to the rarity of PSC, there are few reports focus on the CT radiomics of PSC. However, the preoperative diagnosis of PSC is important and remains challenging. The aim of the study is to explore the feasibility of preoperative differentiation of PSC from other NSCLC based on CT findings and radiomics, so as to improve the accuracy of radiological diagnosis of PSC. Methods 31 patients with PSC and 56 patients with other NSCLC were retrospectively analyzed. CT findings included tumor size, tumor location, calcification, vacuole/cavity, pleural invasion, and low-attenuation area (LAA) ratio. A total of 851 radiomics features were extracted from each CT phase data, including the plain scan (PS), arterial phase (AP) and venous phase (VP). The training and testing cohorts were created in an 8:2 ratio, and the top-ranked 11 features were selected using least absolute shrinkage and selection operator (LASSO) method. Seven machine learning algorithms (DT, GBDT, LDA, LR, RF, SVM, and XGBoost) were applied for the differential diagnosis of PSC and other NSCLC. Results The median survival times of PSC and other NSCLC were 8 months (95% CI 2.123–13.877) and 34 months (95% CI 22.920–45.080), respectively. The mean tumor size of PSC (2.0-9.3 cm) and other NSCLC (2.1–9.7 cm) was 5 cm, and the difference was not statistically significant. Compared to other NSCLC, PSC had a larger LAA ratio (P < 0.001), with an optimal cutoff value of 16.6%, and a sensitivity and specificity of 0.806 and 0.732, respectively. In CT radiomics, PS data combined with logistic regression (LR) algorithm yielded the highest diagnostic efficacy, and the area under the curve (AUC), accuracy, sensitivity and specificity were 0.972, 0.944, 0.833 and 1.000, respectively. Conclusions CT findings and radiomics showed efficient performance in the differential diagnosis of PSC from other NSCLC, which is helpful for the preoperative diagnosis of PSC.
Serum interleukin-1 is a new biomarker to predict the risk of rebleeding of ruptured intracranial aneurysm after admission
Authors: Wen Zheng , Liu Qingyuan , Jiang Pengjun , Zhu Chengcheng , Li Jiangan , Wu Jun , Wang Shuo , Ning Bo 
Published: January 2023

Abstract
Interleukin-1 (IL-1) could induce inflammation of the aneurysm wall, which might be related to intracranial aneurysm rupture. The aim of this study was to investigate whether IL-1 could serve as a biomarker to predict the risk of rebleeding after admission. Data between January 2018 and September 2020 were collected from patients with ruptured intracranial aneurysms (RIAs) and were retrospectively reviewed. The serum IL-1β and IL-1ra levels were detected using a panel, and IL-1 ratio was calculated as the log10(IL-1ra/IL-1β). The predictive accuracy of IL-1 compared with previous clinical morphology (CM) model and other risk factors were evaluated by the c-statistic. 538 patients were finally included in the study, with 86 rebleeding RIAs. The multivariate Cox analysis confirmed aspect ratio (AR) > 1.6 (hazard ratio (HR), 4.89 [95%CI, 2.76–8.64], P < 0.001), size ratio (SR) > 3.0 (HR, 2.40 [95%CI, 1.34–4.29], P = 0.003), higher serum IL-1β (HR, 1.88 [95%CI, 1.27–2.78], P = 0.002) and lower serum IL-1ra (HR, 0.67 [95%CI, 0.56–0.79], P < 0.001) as the independent risk factors for rebleeding after admission. According to the c-statistics, the IL-1 ratio had the highest predictive accuracy (0.82), followed by IL-1ra and IL-1β (0.80), AR > 1.6 (0.79), IL-1ra (0.78), IL-1β (0.74) and SR > 3.0 (0.56), respectively. Subgroup analysis based on AR and SR presented similar results. The model combining IL-1 ratio and CM model showed higher predictive accuracy for the rebleeding after admission (c-statistic, 0.90). Serum IL-1, especially IL-1 ratio, could serve as a biomarker to predict the risk of rebleeding after admission. Unique identifier: ChiCTR1900024406, retrospectively registered.
Satisfaction and Self-Confidence among Nursing Students with Simulation Learning During COVID-19
Authors: Alsadi Mohammad , Oweidat Islam , Khrais Huthaifah , Tubaishat Ahmad , Nashwan Abdulqadir 
Published: January 2023

Abstract
Aim: This survey aimed to investigate nursing students’ satisfaction and self-confidence in simulation in education during the COVID-19 pandemic.
Design: A cross-sectional survey.
Methods: The survey was conducted at the faculty of nursing of a private university in Jordan. Students’ satisfaction and self-confidence levels in simulation learning were measured using the National League for Nursing (NLN) Student Satisfaction and Self-confidence in Learning Scales.
Results: A total of 138 undergraduate nursing students participated in the survey. Students’ satisfaction levels and self-confidence in simulation learning were lower (just above the midpoint of the scale) than scores reported in similar surveys. The lowest student ratings were reported as “the variety of learning activities that can be done using simulation” and “the self-confidence to develop the needed skills and knowledge to be used in real clinical settings”. The results also indicated that as students progress in the bachelor’s degree program, they develop higher levels of self-confidence in simulation learning.
Conclusions: Nursing students' experience of simulation learning was affected by the COVID-19 pandemic, showing the need for high-fidelity simulation. Education stakeholders are invited to invest in the resources of high-fidelity simulation to maximize its benefits and help in the recovery phase after the pandemic.
Low hepatic artery resistive index on the first post-transplant day is associated with inferior graft survival in adult liver transplantation
Authors: Capra Rodrigo P. , Lazzarotto-da-Silva Gabriel , Grezzana-Filho Tomaz J. M. , Viana Gabriel S. , Prediger João E. , Rabolini Bruno , Silva Rafaela K. , Prediger Lucas , Araujo Alexandre , Alvares-da-Silva Mario R. , Feier Flavia H. , Chedid Marcio F. , Kruel Cleber R. P. 
Published: January 2023

Abstract
Purpose
Although liver transplantation (LT) outcomes have improved significantly over the last decades, early post-transplant vascular complications are still associated with an elevated risk of graft failure. Doppler ultrasound (DUS) enables detection of vascular complications and provides hepatic artery Resistive Index (RI). The aim of our study was to evaluate the association of the RI parameters of DUS performed in the first post-transplant week with post-transplant outcomes.
Methods
All consecutive patients undergoing a first LT between 2001 and 2019 at a single center were included. P were divided into three groups: RI < 0.55, RI 0.55–0.85 and RI > 0.85. Patients were also divided according to the presence or absence of hepatic artery thrombosis (HAT). Graft survival was compared among groups.
Results
Three hundred and forty-four patients were included. HAT occurred in 23 patients (6.7%), of which 7 were partial and 16 were complete. Biliary complications were more common in patients with HAT (11 [47.8%]) vs. 44 [13.4%] [p < 0.001]). There was no statistically significant difference in graft survival between patients with and without HAT. Patients with RI < 0.55 on post-operative day 1 had worse graft survival compared to patients with RI 0.55–0.85 and RI > 0.85. RI on post-operative day 3 and 5 was not predictive of graft survival.
Conclusions
The use of DUS on liver transplant recipients in the early post-transplant period offers the possibility of early diagnosis of vascular complications. Additionally, according to our data, low RI (< 0.55) on the first postoperative day also provides prognostic information regarding graft-survival.
The 3Po states of exotic molecular ions with exponential-cosine-screened Coulomb potentials
Authors: Fu Xin Yan , Jiang Zishi , Kar Sabyasachi 
Published: January 2023

Abstract
We investigate the bound states, Borromean states and resonant states for the 3Po (J = 1) states of \(pp\mu\), \(dd\mu\) and\(tt\mu\) molecular ions interacting with exponential-cosine-screened Coulomb potential. The bound 3Po state energies are calculated using the Rayleigh-Ritz variational method and the resonance parameters are calculated using the stabilization method. Highly correlated exponential wave functions are used. The bound 3Po state energies, the 3Po resonance parameters (energy and width), along with 1S and 2S threshold energies of the \(p\mu\), \(d\mu\) and\(t\mu\) atoms are also reported for different shielding parameters. The critical values of the screening parameters for the 3Po states are also reported for which the three-body exotic molecular systems are stable while all the possible fragments are unbound, that is shows windows for Borromean binding.