bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous Coronary Intervention Associated with a Higher Risk
of Hypoxemia and COVID-19 Severity
Authors: Shayan Sepideh Karkon , Nasrollahi Elham , Bahramvand Yaser , Zarei Mahdi , Atarodi Ahmadreza , Farsi Yeganeh , Tavakolizadeh Mitra , Shirvaliloo Milad , Abbasifard Mitra , Jamialahmadi Tannaz , Banach Maciej , Sahebkar Amirhossein 
Published: February 2023

Objective:
The primary goal of the present study was to measure the implications
of hypoxemia in COVID-19 patients with a history of coronary artery disease
(CAD).

Methods:
A systematic search of the literature published from November 1, 2019 to May
1, 2021, was conducted on PubMed/MEDLINE, Embase, and Web of Science databases.
Afterwards, an observational study was designed based on the electronic health records
of COVID-19 patients hospitalized in a tertiary referral hospital during the same period.
A total of 179 COVID-19 cases were divided into two groups: cases with a history of
CAD and percutaneous coronary intervention (CAD/PCI+, n = 89) and controls (n = 90).
Clinical data were extracted from the electronic database of the hospital and statistically
analyzed.

Results:
After the application of inclusion/exclusion criteria, only three studies were
deemed eligible, one of which was concerned with the impact of CAD on the all-cause
mortality of COVID-19. Results from our observational study indicated that the cases
were older (median age: 74 vs. 45) and more likely to develop hypoxemia (25.8% vs.
8.8%) than the controls. CAD/PCI+ was correlated with a more severe COVID-19 (11%
vs. 1%). Age was a moderately significant independent predictor of increased COVID-19
severity, while hypoxemia was not.

Conclusion:
Considering the negative impact of hypoxemia on the prognosis of
COVID-19 and its higher prevalence among COVID-19 patients with underlying CAD,
further research is warranted to unravel the negative effects of COVID-19 on the mechanisms
of gas exchange and delivery in patients with pre-existing CAD.
Investigating the Effects and Mechanism of Rhodiola Rosea Injection on
Cardiac Function in Rats with Chronic Heart Failure
Authors: Li Xiuqin , Chen Shaopeng , Shao Weihua , Wang Suxing , Yao Lixia 
Published: February 2023

Aim:
To study the effect of Rhodiola rosea injection on cardiac function and the reninangiotensin-
aldosterone system (RASS) in rats with chronic heart failure

Background:
Rhodiola rosea injection, a traditional Chinese medication for relieving blood stasis and
improving blood circulation, is an excellent therapeutic for treating coronary heart disease-angina pectoris.
Rhodiola rosea injection's major component, salidroside, protects the cardiovascular system. But there
isn't much first-hand evidence about how injectable Rhodiola rosea affects heart failure

Objectives:
In this study, a rat model of heart failure was established, and the effect of Rhodiola
rosea injection on myocardial cell morphology, cardiac function, and ventricular remodelling in
rats with heart failure was investigated.

Methods:
66 SD male rats were selected; 10 were randomly selected as a blank control group, and
56 were treated intraperitoneally with doxorubicin (4 g/g). After 6 weeks, all animals had LVEF
60%. Established a heart failure model. Each group had 14 rats: model control, low-dose, mediumdose,
and high-dose Rhodiola rosea injection. The 2mL/kg of Rhodiola rosea injection was injected
into the tail vein once a day for 2 weeks. Both the blank and control groups received normal daily
saline. After 2 weeks, the echocardiographic index, RASS-related index, and serum BNP level
were assessed in all rats, and myocardial tissue morphology was observed. MiRNA423-5p, miRNA499-
5p, and miRNA210-3p were extracted from peripheral blood. Rhodiola rosea injection on
its expression was compared to healthy control rats.

Results:
6 mL/kg Rhodiola rosea injection lowered LVEDV and LVESV while increasing LVEF
and LVFS. Injections of 6 mL/kg Rhodiola rosea reduce plasma levels of miR-210-3p, miR-423-
5p, miRNA-499, and BNP in heart failure model rats. The 6 mL/kg Rhodiola rosea injection can
restore the RASS indexes of heart failure rats to the level of the normal group.

Conclusion:
The present study offers preliminary evidence supporting the use of Rhodiola rosea
injection in the treatment of heart failure and offers a solid foundation for clinical off-label medication
use.
Application of Cell Membrane-Coated Nanomaterials for Tumor Treatment
Authors: Zhu Yanzhao , Cui Hengqing , Zhang Jin , Bei Ying , Huang Yu , Li Meiyun , Liu Jieting , Wu Yan , Gao Jie 
Published: February 2023

Abstract:
Tumors are a major cause of human mortality worldwide, and the rapid development of
nanomaterials (NMs) for tumor therapy and drug delivery has provided new treatment methods. However,
NMs’ high immunogenicity, short circulation time, and low specificity limit their application in
tumor therapy. In recent years, bionanomaterials using cell membranes have emerged to overcome the
shortcomings of monomeric NMs. Cell membrane-encapsulated NMs extracted from multiple cells
not only retain the physicochemical properties of NMs but also inherit the biological functions of the
source cells, aiding in drug delivery. The combination of the cell membrane and drug-loading NMs
offers an efficient and targeted drug delivery system tailored to the tumor microenvironment. The
research and application of this method have been widely carried out in the academic field of tumor
diagnosis and treatment. This review presents the recent research progress of cell membrane-coated
NMs as drug carriers in tumor therapy, including cell membrane extraction methods, encapsulation
strategies, and the applications of cell membrane-encapsulated NMs in tumor therapy. We believe that
biomimetic nanomaterials will be a promising and novel anticancer strategy in the future, and their
wide application will certainly bring vitality to the field of tumor diagnosis and treatment. The combination
of membrane and drug-loading nanomaterials embodies a highly efficient and target drug delivery
system tailored to the tumor microenvironment, which broadens a new path of drug delivery for
future cancer treatment. Meanwhile, it is also a perfect combination and application of biomedical
nanomaterials, which is of great significance.
Emerging Roles of Microglia in Blood-Brain Barrier Integrity in Aging
and Neurodegeneration
Authors: Zhang Simeng , Meng Rui , Jiang Muzhou , Qing Hong , Ni Junjun 
Published: February 2023

Abstract:
The blood-brain barrier (BBB) is a highly selective interface between the blood and the
brain parenchyma. It plays an essential role in maintaining a specialized environment for central nervous
system function and homeostasis. The BBB disrupts with age, which contributes to the development
of many age-related disorders due to central and peripheral toxic factors or BBB dysfunction.
Microglia, the resident innate immune cells of the brain, have recently been explored for their ability
to directly and indirectly regulate the integrity of the BBB. This review will focus on the current understanding
of the molecular mechanisms utilized by microglia to regulate BBB integrity and how this
becomes disrupted in aging and age-associated diseases. We will also discuss the rationale for considering
microglia as a therapeutic target to prevent or slow down neurodegeneration.
The Gut-Brain Axis and the Microbiome in Anxiety Disorders,
Post-Traumatic Stress Disorder and Obsessive-Compulsive Disorder
Authors: MacKay Marnie , Yang Bohan H. , Dursun Serdar M. , Baker Glen B. 
Published: February 2023

Abstract:
A large body of research supports the role of stress in several psychiatric disorders in which
anxiety is a prominent symptom. Other research has indicated that the gut microbiome-immune system-
brain axis is involved in a large number of disorders and that this axis is affected by various
stressors. The focus of the current review is on the following stress-related disorders: generalized anxiety
disorder, panic disorder, social anxiety disorder, post-traumatic stress disorder and obsessivecompulsive
disorder. Descriptions of systems interacting in the gut-brain axis, microbiome-derived
molecules and of pro- and prebiotics are given. Preclinical and clinical studies on the relationship of
the gut microbiome to the psychiatric disorders mentioned above are reviewed. Many studies support
the role of the gut microbiome in the production of symptoms in these disorders and suggest the potential
for pro- and prebiotics for their treatment, but there are also contradictory findings and concerns
about the limitations of some of the research that has been done. Matters to be considered in future research
include longer-term studies with factors such as sex of the subjects, drug use, comorbidity, ethnicity/
race, environmental effects, diet, and exercise taken into account; appropriate compositions of
pro- and prebiotics; the translatability of studies on animal models to clinical situations; and the effects
on the gut microbiome of drugs currently used to treat these disorders. Despite these challenges, this is
a very active area of research that holds promise for more effective, precision treatment of these stressrelated
disorders in the future.
Whole-cell Lipase Catalytic Synthesis of Short-chain Fragrance Esters
using Aspergillus flavus
Authors: Rath Santosh K. , Kaur Gurpinder , Sharma Anirudh , Singh Anmol , Prakash Ranjana , Mandal Sudip , Prakash Nagaraja Tejo 
Published: February 2023

Background:
Fragrances are the collection of unlike functional assemblies, most likely alcohols,
esters, aldehydes, ketones, and acids in organic products/hydrocarbons. Short-chain aliphatic fragrance
esters have immense applications as flavors in the food, pharmaceutical and cosmetic industries
and also have remarkable commercial significance in cosmetics and personal care products like perfumes,
face creams, shampoos, soaps, lotions, jams, jellies, etc.

Objective:
This study aimed to synthesize short-chain fragrance esters using a whole-cell lipase catalyst
from Aspergillus flavus (RBD-01).

Method:
The present study emphasizes the synthesis of artificial flavoring compounds by using a wholecell
biocatalytic process, which can have wide significance. Herein, the preparation of ethyl alkanoates
(ethyl propanoate to ethyl decanoate) was performed to investigate the flavors and fragrance excellence.
The biomass from Aspergillus flavus (RBD-01) was used as a catalyst to facilitate the remarkable esterification
activities towards the synthesis of important aroma esters with the help of a series of short-chain
acids and alcohols.

Result:
The ethyl hexanoate (4) among all synthesized alkanoates was found to have a fruity fragrance
with a good conversion rate. Further synthesized alkyl hexanoates (4A-4I) were found to have good
fruity/pineapple/berry flavors and significant aroma quality.

Conclusion:
These results implied that whole-cell lipase of Aspergillus flavus (RBD-01) is a promising
biocatalyst in the production of flavor aroma esters and can boost production in the food/cosmetic manufacturing
industries.
Synthesis and Activity of Aurone and Indanone Derivatives
Authors: Wu Heng , Zhao Haiqing , Lu Tong , Xie Baoxing , Niu Chao , Aisa Haji Akber 
Published: February 2023

Introduction:
Based on bioactive group splicing, classical bioisosterism, and the rule of
alkene insertion, forty-eight aurone, and indanone derivatives were designed and synthesized. They
were evaluated for inhibitory activity against C. albicans, E. coli, and S. aureus. Among them, thirty
compounds exhibited moderate to excellent antibacterial activity.

Method:
The maximum circle of inhibition was 18 mm (compounds B15, B16, and E7), and the
minimum values of MIC and MBC were respectively 15.625 μM (compounds A5 and D2) and 62.5
μM (compounds A6, A8, and E7).

Results:
The SAR showed that aurone and indanone derivatives could strongly inhibit the growth of
Gram-positive bacteria. The introduction of electron-withdrawing groups or hydroxyl is beneficial to
the activity. It was exciting that the 3-phenylallylbenzofuranone and 3-allylindanone skeletons with
antimicrobial activity were first reported in this study. Compounds A5 and E7 were selected for molecular
docking studies with targets MetRS (PBD: 7WPI) and PBP (PDB: 6C3K) to determine the
binding interactions at the active site.

Conclusion:
On this basis, the physicochemical and pharmacological properties of the compounds
were predicted and analyzed. The influence of these properties on antimicrobial activity and their
implications for subsequent work were discussed. The ADMET (Absorption, Distribution, Metabolism,
Excretion, Toxicity) predictions showed that most of the compounds had good pharmacokinetic
profiles and high safety profiles.
Establishment of HLB-UPLC-MS/MS Method to Determine Hainanmycin
Sodium in Chicken Liver
Authors: Zhao Junjie , Cheng Linli , Chen Yanan , Chen Kexin , Luan Yehui 
Published: February 2023

Objective:
Controlling coccidiosis disease in poultry is significant for healthy breeding, but
antibiotic residues can pose a great threat to food safety, the ecological environment, and human
health. A special anticoccidial drug called Hainanmycin has been widely used in Asian countries for
many years, while a few studies focus on its detection. In this study, we established a hydrophiliclipophilic
balance (HLB) purification and ultra-performance liquid chromatography-tandem mass
spectrometry (UPLC-MS/MS) method to determine the hainanmycin in chicken liver.

Methods:
It was extracted from the sample with 0.1% formic acid-methanol (10+90, v/v) and then it
was purified on a hydrophilic-lipophilic balance (HLB) cartridge. Chromatography separation was
performed on an RP-C18 column, and detection of the hainanmycin was done by positive electrospray
ionization (ESI＋) under the multiple reaction monitoring (MRM) modes.

Results:
The quantification ion pair was m/z 907.5 and m/z 846.4. The calibration curve showed excellent
linearity in the range of 10 to 1000 μg·L-1, with a correction coefficient of 0.99. When spiked
at 5, 100, and 500 μg·kg-1, the recoveries ranged from 80.82% to 88.09%, with the intra-day and interday
coefficients of variation from 10.76% to 13.48% and from 10.80% to 12.71%, respectively. The
limit of quantification (LOQ) and detection(LOD) were 5.05 μg·mL-1 and 1.55 μg·mL-1, respectively.

Conclusion:
This method showed high sensitivity and accuracy for determining hainanmycin in
chicken liver.
Review on the Encapsulation, Microencapsulation, and Nano-
Encapsulation: Synthesis and Applications in the Process Industry for
Corrosion Inhibition
Authors: Gujar Jotiram , Patil Sanjay , Sonawane Shriram 
Published: February 2023

Background:
Surfaces of materials often corrode and deteriorate due to environmental
conditions. There are various widely used methods of reducing corrosion rates to increase the
lifetime of materials and equipment. Recently, there has been a growth in the use of nanotechnology
to protect metals against corrosion. The application of nano-encapsulation techniques in
the process industry is one of the important eras of nanotechnology. This review paper focuses
on encapsulation, microencapsulation, and nano-encapsulation methods, emphasizing nanoencapsulation
applications as corrosion inhibitions in the process industry.

Methods:
Materials based on the self-healing mechanism were used in advanced applications
such as structures, batteries, and coatings. These technologies may be studied in two ways: compounds
with intrinsic self-healing properties and extrinsic self-healing materials with additives
such as microcapsules filled with healing agents. Nano-coatings have advantages, like accelerated
ground hardness, adhesive energy, long-time period and/or high-temperature corrosion resistance,
tribological residence enhancement, etc. Nano-coatings can also be carried out in thinner
and smoother layers, considering flexibility, accelerated performance, decreased fuel costs,
and smaller carbon footprints, as well as occasional maintenance. The review of corrosion characteristics
of polymeric nanocomposite material was discussed in this paper.

Results:
This review paper presents an updated overview summarizing the latest advances in the
various micro/nanocarriers used for self-healing corrosion protective coatings.

Conclusion:
With this information, the investigators will be able to modify the structure of the
inhibitor to get the necessary corrosion inhibition capabilities. The need for a physical examination
is rising as a result.
Effects of Active Compounds of Nigella sativa in COVID-19: A
Narrative Review
Authors: Usmani Hina , Malik Saloni , Arya Anshu , Mahto Pintu Kumar , Kant Ravi , Dua Ruchi , Sindhwani Girish , Mirza Anissa Atif , Panda Prasanna Kumar 
Published: February 2023

Background:
SARS-CoV-2 infection that led to the COVID-19 pandemic has
changed human health and the economy globally. SARS-CoV-2 is a type of Coronaviruses
that has caused pneumonia and its complications with many deaths over the past two years.
The use of hydroxychloroquine and chloroquine, accepted as generally safe for patients
with autoimmune diseases or malaria, was attempted in many trials for COVID-19 treatment.
Nigella sativa (NS) (black caraway, also known as black cumin, Nigella or Kalonji)
is an annual flowering plant of the Ranunculaceae family, chemically composed of the
main constituent natural Thymoquinone (TQ) (30%-48%) in forms of thymohydroquinone,
dithymoquinone (Nigellone) is a native to wider regions, including parts of eastern Europe,
west Asia, North of Africa and east of Myanmar. In this review, we explored the Randomized
Controlled Trial, Controlled Trial, and Systematic review studies that support Nigella
sativa Thymoquinone-targeted SARS-CoV-2 targeting. Therefore, A literature search was
performed for publications published on the electronic databases (PubMed, Embase, Scopus,
CNKI, and Google Scholar) for Nigella sativa, black seeds, Kalonji, coronavirus,
SARS-CoV-2 and COVID-19. This review aimed to find relevant evidence of Nigella sativa
preferences as a natural feasible remedy with no side effects in COVID-19. Studies reported
the benefits of NS as beneficial, another appropriate remedy for patients with
COVID-19. However, all studies have shown limitations, such as limiting clinical symptom
outcomes due to regulations imposed by isolation policies and lack of adequate funding.
Therefore, the evidence suggests that the chemical contents of NS are a safe and possible
treatment for COVID-19 patients that helps to improve COVID-19 infection in patients
with no side effects.

Conclusion:
Nigella sativa seeds were one of the well-documented herbal products. Three
reviewed randomized controlled trials reported that NS reduced COVID-19 risk and could
improve immune function. It was also helpful in upper respiratory infections such as asthma
and bronchitis, with one RCT showing that honey and NS significantly improved
symptoms, viral clearance, and mortality of COVID-19 patients. This review concludes
that NS has a positive barrier effect on people at risk of acquiring a COVID-19 infection.
Mobile Phone Apps for HIV Prevention Among College-Aged Black Women in Atlanta: Mixed Methods Study and User-Centered Prototype
Authors: Tesema Naomi , Guillaume Dominique , Francis Sherilyn , Paul Sudeshna , Chandler Rasheeta 
Published: February 2023

Background
Black women in college are disproportionately affected by HIV diagnoses. Mobile apps can facilitate the innovative delivery of accurate HIV and sexual and reproductive health information. However, mobile health interventions are severely underused in this population.

Objective
We aimed to quantitatively and qualitatively explore the perspectives of college-aged Black women on using a mobile health app for HIV prevention and sexual and reproductive health. The data obtained from Black women were used to design preliminary mobile app wireframes and features.

Methods
This explanatory, sequential mixed methods study took place from 2019 to 2020 and targeted Black women who were enrolled in college or who had recently graduated from college. Convenience sampling was used during the quantitative phase, followed by purposive sampling in the qualitative phase. A cross-sectional web-based survey evaluating the willingness to use a mobile app for HIV prevention was conducted in the quantitative phase. Descriptive statistics were used for all variables. A separate focus group discussion was conducted with Black women in college to expand on the quantitative results. Focus group discussions explored their perceptions on HIV and health content delivered through a mobile app along with potential features that participants desired within the app. Using the data obtained, we selected the primary features for the app prototype.

Results
In total, we enrolled 34 participants in the survey, with 6 participating in focus group discussions. Over half of the respondents reported a willingness to use an app that contained pre-exposure prophylaxis content. Women who claimed recent sexual activity reported being more likely to use an app feature that would allow them to order an at-home HIV testing kit than their non–sexually active counterparts. The emerging themes from the focus group session were Black women’s health concerns, HIV risk, sources of health information, and preferred app features. The content in our prototype included speaking with a specialist, HIV and pre-exposure prophylaxis information, holistic wellness, and features promoting engagement and retention.

Conclusions
The results of our study guided the design of wireframes for an app prototype targeting HIV prevention in college-aged Black women. The rapid growth of mobile devices in Black communities, coupled with high rates of smartphone ownership among Black youth, makes mobile health interventions a promising strategy for addressing sexual and reproductive health disparities. Participants in our sample were willing to use a culturally appropriate and gender-considerate app for their sexual health needs. Our findings indicate that Black women in college may be excellent candidates for mobile app–based interventions.