bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growth and applications of two-dimensional single crystals
Authors: Zhang Zhibin , Forti Stiven , Meng Wanqing , Pezzini Sergio , Hu Zehua , Coletti Camilla , Wang Xinran , Liu Kaihui 
Published: March 2023

Abstract
Two-dimensional (2D) materials have received extensive research attentions over the past two decades due to their intriguing physical properties (such as the ultrahigh mobility and strong light–matter interaction at atomic thickness) and a broad range of potential applications (especially in the fields of electronics and optoelectronics). The growth of single-crystal 2D materials is the prerequisite to realize 2D-based high-performance applications. In this review, we aim to provide an in-depth analysis of the state-of-the-art technology for the growth and applications of 2D materials, with particular emphasis on single crystals. We first summarize the major growth strategies for monolayer 2D single crystals. Following that, we discuss the growth of multilayer single crystals, including the control of thickness, stacking sequence, and heterostructure composition. Then we highlight the exploration of 2D single crystals in electronic and optoelectronic devices. Finally, a perspective is given to outline the research opportunities and the remaining challenges in this field.
The Role of Environmental Context and Physical Activity in Prescribed Opioid Use and Pain in Daily Life among Patients With Chronic Low Back Pain
Authors: Carpenter Ryan W , Acuff Samuel F , Meshesha Lidia Z 
Published: March 2023

Abstract

Background
Prescription opioids remain a primary treatment option for patients with chronic low back pain. However, little research has examined how patients take opioids in daily life. Behavioral economics suggest that the environmental context may contribute to patients’ decisions around opioid use.

Purpose
This study examined the association of self-reported environmental factors and physical activity with likelihood of taking opioids, opioid dosage, and physical pain.

Method
Patients with chronic low back pain on long-term opioid therapy (n = 34) without significant past-year opioid-related problems completed a two-week ecological momentary assessment protocol (nobservations = 1,714).

Results
Initial multilevel models revealed multiple associations for different specific contexts with opioid use and pain. In models that collapsed specific contexts into categories (where, with whom, doing what), greater occasion-level physical activity was associated with a greater likelihood of taking opioids and greater pain, and being somewhere (v. at home) was associated with taking a smaller opioid dose. At any given occasion, being with someone (v. alone) was associated with taking a larger opioid dose, but patients who spent more time with others over the entire study took fewer opioids overall. Multilevel mediation found that pain did not mediate the association of physical activity and opioid use.

Conclusion
Results suggest that prescribed opioid use in patients with chronic low back pain is not solely determined by pain, but influenced by environmental factors, including physical activity. Psychoeducation regarding environmental factors, including how factors may be associated with both increased and decreased use of opioids, may help patients take fewer opioids more effectively.
Identification of recurrent atrial fibrillation using natural language processing applied to electronic health records
Authors: Zheng Chengyi , Lee Ming-sum , Bansal Nisha , Go Alan S , Chen Cheng , Harrison Teresa N , Fan Dongjie , Allen Amanda , Garcia Elisha , Lidgard Ben , Singer Daniel , An Jaejin 
Published: March 2023

Abstract

Aims
This study aimed to develop and apply natural language processing (NLP) algorithms to identify recurrent atrial fibrillation (AF) episodes following rhythm control therapy initiation using electronic health records (EHRs).

Methods and results
We included adults with new-onset AF who initiated rhythm control therapies (ablation, cardioversion, or antiarrhythmic medication) within two US integrated healthcare delivery systems. A code-based algorithm identified potential AF recurrence using diagnosis and procedure codes. An automated NLP algorithm was developed and validated to capture AF recurrence from electrocardiograms, cardiac monitor reports, and clinical notes. Compared with the reference standard cases confirmed by physicians’ adjudication, the F-scores, sensitivity, and specificity were all above 0.90 for the NLP algorithms at both sites. We applied the NLP and code-based algorithms to patients with incident AF (n = 22 970) during the 12 months after initiating rhythm control therapy. Applying the NLP algorithms, the percentages of patients with AF recurrence for sites 1 and 2 were 60.7% and 69.9% (ablation), 64.5% and 73.7% (cardioversion), and 49.6% and 55.5% (antiarrhythmic medication), respectively. In comparison, the percentages of patients with code-identified AF recurrence for sites 1 and 2 were 20.2% and 23.7% for ablation, 25.6% and 28.4% for cardioversion, and 20.0% and 27.5% for antiarrhythmic medication, respectively.

Conclusion
When compared with a code-based approach alone, this study's high-performing automated NLP method identified significantly more patients with recurrent AF. The NLP algorithms could enable efficient evaluation of treatment effectiveness of AF therapies in large populations and help develop tailored interventions.
Ovarian stimulation does not induce thyrotropin receptor autoantibodies in women with thyroid autoimmunity
Authors: Poppe Kris Gustave , Frommer Laura , Hatun Burak , Autin Candice , Wolff Fleur , Kahaly George Jean 
Published: March 2023

AbstractWomen of subfertile couples with thyroid autoimmunity (TAI) have an increased risk of miscarriage when pregnant after an assisted reproductive technology (ART) treatment. This might amongst others be due to the presence of thyrotropin receptor antibodies (TSH-R-Ab) that can impede the development of the corpus luteum. TSH-R-Ab can be present in women with TAI and/or be induced by the ovarian stimulation procedure (OS) that is performed to initiate the ART. In this prospective pilot study, we determined the presence of both binding and functional TSH-R-Ab (stimulating or blocking) with five different assays before and after OS in ten women (eleven cycles) with TAI of subfertile couples and in one woman without TAI. Mean (SD) age was 38.8 (±3.2) years, median (range) cumulative OS dose 1413 (613-2925) IU/L. Median baseline serum levels of thyrotropin, free thyroxine, and thyro-peroxidase antibodies were 2.33 (2.23-2.61) mIU/L, 16.8 (14.4-18.5) pmol/L and 152 (86-326) kIU/L, respectively. Oestradiol levels increased during OS from 40 (26-56) ng/L to 963 (383-5095) ng/L; P &lt; .01. TSH-R-Ab measurements in all subject samples were below the cut-off of the corresponding immunoassay and four bioassays before or after OS.
Malocclusions and quality of life among adolescents: a systematic review and meta-analysis
Authors: Göranson Emma , Sonesson Mikael , Naimi-Akbar Aron , Dimberg Lillemor 
Published: March 2023

SummaryBackgroundMalocclusions in adolescents might have a negative impact on oral health-related quality of life (OHRQoL). Potential confounding variables (confounders) such as age, gender, caries, and socioeconomic status may skew the real relationship between malocclusions and OHRQoL.ObjectivesTo analyse the effect of malocclusions in adolescents on OHRQoL, when controlled for potential confounders.Search methodsFive databases (PubMed, Cochrane Library, Cinahl, Scopus, and Web of Science) were searched up to 15 June 2022.Selection criteriaStudies in which OHRQoL in 10–19-year olds with and without malocclusions were compared.Data collection and analysisScreening, data extraction, and quality assessments were performed by four investigators independently. Risk of bias was assessed according to the Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU) guidelines. To be included, studies had to control for confounders. Certainty of evidence was assessed with GRADE.ResultsThirteen cross-sectional studies with low and moderate risk of bias were included in the qualitative synthesis. Four of these were also included in the quantitative synthesis (meta-analysis). The 13 studies in the qualitative synthesis displayed a large variation among the indices used for malocclusion ratings, as well as in instruments measuring OHRQoL. There was moderate quality of evidence that malocclusions have a negative effect on OHRQoL. The four articles included in the quantitative synthesis (meta-analysis) measured malocclusions with DAI and OHRQoL with CPQ 11–14 short form. There was moderate quality of evidence that malocclusions have a negative effect on OHRQoL (RR/PR 1.15, 95% CI 1.12–1.18, 3672 participants).ConclusionsThere is moderate quality of evidence that malocclusions in adolescents have a negative impact on OHRQoL, after taking relevant confounders into consideration. Future studies should ideally use standardized measures for malocclusion ratings and OHRQoL.RegistrationPROSPERO. CRD42020186152.
Murine herpesvirus-68-related growth factors treatment correlates with decrease of p53 and HIF-1α protein levels
Authors: Supolikova Miroslava , Novakova Eva , Donatova Karin , Olejnikova Petra , Labudova Martina 
Published: March 2023

AbstractMurine herpesvirus 68 (MHV-68) belongs to the subfamily Gammaherpesvirinae of the family Herpesviridae. This exceptional murine herpesvirus is an excellent model for the study of human gammaherpesvirus infections. Cells infected with MHV-68 under nonpermissive conditions for viral replication produce substances designated as MHV-68 growth factors (MHGF-68), that can cause transformation of the cells, or on the other side, turn transformed cells into normal. It was already proposed, that the MHGF-68 fractions cause transformation, disruption of the cytoskeleton and slower growth of the tumors in nude mice. Here, we examined newly extracted fractions of MHGF-68 designated as F5 and F8. Both fractions proved to inhibit the growth of the spheroids and also tumours induced in nude mice. What more, the fractions caused the decrease of the protein levels of wt p53 and HIF-1α. Decreased levels of p53 and HIF-1α activity leads to decreased vascularization, slower tumour growth, and lower adaptation to hypoxic conditions. This would propose MHGF-68 fractions, or their human herpesvirus equivalents, as a potential anticancer drugs in combined chemotherapy.
Development and evaluation of health education resources for culturally and linguistically diverse populations: a systematic review
Authors: Gray Corie , Porter Georgia , Lobo Roanna , Crawford Gemma 
Published: March 2023

Abstract
People from culturally and linguistically diverse (CaLD) backgrounds in Australia generally experience poorer health outcomes, explained in part by low levels of health literacy. We conducted a systematic review to examine the development and evaluation of health education resources designed for CaLD populations. Five electronic databases were searched for English language, peer-reviewed studies published between 1980 and 2020. Thirty-four studies met the inclusion criteria. Twenty-four different health education resources were described and broadly categorized into four types: media campaigns (n = 10), text-based materials (n = 5), films (n = 8) and radio (n = 1). Studies were assessed against domains adapted from a health literacy guideline incorporating: need, collaboration, audience, health literacy, theory, test and process and impact evaluation. All but one study met the majority of the domains. All studies reported positive evaluation outcomes; this may be due to studies involving community early in resource design and including health literacy considerations in their design. Reporting resource design and evaluation against standard practice controls is recommended to build a more robust evidence base for developing effective health education resources for use by audiences from CaLD backgrounds.
Artwork That Helps Frame History: Toward a Visual Historical and Sociological Analysis of Works Created by Prisoners from the Terezin Ghetto
Authors: Johnson Willa M 
Published: March 2023

Abstract
This article uses qualitative content analysis, historical archival data, and interviews with Holocaust survivors to examine artwork created during the Third Reich. It argues that these works are visual narratives that hold important empirical data about social conditions and structures during the Third Reich. These narratives, whether developed in prisons, camps, or ghettos, or in the aftermath of National Socialism, are key to understanding the victims’ perspectives. Many works disclose intimate aspects of daily life that only victims saw and experienced. Thus, this artwork is an extremely valuable source for understanding prisoners’ lives during the Third Reich. The article focuses on four examples: Karl Schwesig’s prewar experiences illustrated in a series of prints that tell about his torture and the torture of other German Communists in a Düsseldorf jail; Malvina Schalekova’s 1942–1944 drawings and paintings that expose daily life in the Terezin Ghetto; Fredrick Terna’s postwar recollections about the camp at Dachau near the end of World War II; and Yehuda Bacon’s 1945 retrospective of Auschwitz.
Identification of Lipocalin 2 as a Potential Ferroptosis-related Gene in Ulcerative Colitis
Authors: Deng Liyan , He Shasha , Li Ying , Ding Rui , Li Xiaoling , Guo Nuoqing , Luo Lianxiang 
Published: March 2023

Abstract

Background
Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease generally limited to the mucosa and submucosa of the colon. Recent studies suggest that ferroptosis is a novel programmed cell death that may be involved in the process of UC. However, the mechanism of ferroptosis in UC remains to be further investigated.

Methods
The genes associated with UC and ferroptosis were screened by bioinformatics methods, and a random forest model was constructed to identify the core genes of UC and validated with external data sets. Establishment of dextran sodium sulfate (DSS) induced UC in an animal model in vivo. Interferon (IFN)-γ primed immortalized bone marrow-derived macrophages cells stimulated with Lipopolysaccharides (LPS) inflammation model and LPS-stimulated Caco-2 cells colitis model in vitro were constructed. The potential link between Lipocalin-2 (LCN2) and UC ferroptosis was explored by flow cytometry, Fe2+ assay, Western Blot, gene knockdown, hematoxylin and eosin staining, and immunohistochemistry staining.

Results
Analysis of differentially expressed genes (DEGs) showed that LCN2 was highly expressed in UC. The protein-protein interaction (PPI) networks showed that ferroptosis-associated DEGs were highly correlated with the immune gene LCN2. The most important gene in the random forest model, LCN2, was identified as a core gene in UC. In the LPS/IFN-γ-induced inflammation model, LCN2 expression was elevated, lipid peroxidation, Fe2+, ACSL4 and COX-2 levels increased, whereas GPX4 and FTH1 expression decreased. Similarly, in the DSS-induced UC mouse model, Occludin, ZO-1, Claudin-1, and GPX4 expression were significantly decreased, but ACSL4 and LCN2 expression were elevated. In addition, the use of Ferrostatin-1 (Fer-1) can significantly reverse its trend. More importantly, silencing of LCN2 suppressed ferroptosis events in both the LPS/IFN-γ-induced inflammation model and the LPS-stimulated colitis model.

Conclusion
In conclusion, our study demonstrates that LCN2 is a key factor in the regulation of ferroptosis in UC and provides additional evidence for the important role of ferroptosis in UC.
Unexpected oxidative cracking of diformyltricyclodecanes under catalyst-free and ultra-low temperature
Authors: Dun Linan , Yu Xinyu , Wang Han , Lin Pengmusen , Xiong Ziyao , Guo Xuqiang , Zhang Libo 
Published: March 2023

Abstract
The oxidative cracking of diformyltricyclodecanes (DFTD) to C6–C8 alkenes and alkenes were systematically studied in this work. A series of experiments was performed over a broad range of conditions (temperature: 40–60 °C; oxygen pressure: 0–1.0 Mpa; reaction time: 5–90 min, solvent selection) for exploring the reaction route and mechanism. Results show that the higher temperature and oxygen pressure, as well as tetrahydrofuran (THF) as solvent are of benefit to the generation of cracking products. In addition, the kinetics of this reaction was explored by the dynamic fitting. The obtained kinetics parameters demonstrate that the transformation of intermediate to cracking products possesses higher activation energy than to dicarboxyltricyclodecaneacids (DCTDA), showing that higher temperature is conducive to the generation of DFTD cracking products. This work firstly demonstrated that DFTD could be formed into C6-C8 alkenes containing the same as gasoline compound by the oxidative cracking, suggesting that the by-product of petroleum and coal could be transferred into fuels; this expanded the application of DCPD and will have significant and positive influence on the petroleum and coal chemical industry.
Crossed Product Equivalence of Quantum Automorphism Groups of Finite Dimensional C*-Algebras
Authors: Brannan Michael , Elzinga Floris , Harris Samuel J , Yamashita Makoto 
Published: March 2023

Abstract
We compare the algebras of the quantum automorphism group of finite-dimensional C$^\ast $-algebra $B$, which includes the quantum permutation group $S_N^+$, where $N = \dim B$. We show that matrix amplification and crossed products by trace-preserving actions by a finite Abelian group $\Gamma $ lead to isomorphic $\ast $-algebras. This allows us to transfer various properties such as inner unitarity, Connes embeddability, and strong $1$-boundedness between the various algebras associated with these quantum groups.
Putrescine Biosynthesis from Agmatine by Arginase (TtARG) in Thermus thermophilus
Authors: Kobayashi Teruyuki , Sakamoto Akihiko , Kashiwagi Keiko , Igarashi Kazuei , Takao Koichi , Uemura Takeshi , Moriya Toshiyuki , Oshima Tairo , Terui Yusuke 
Published: March 2023

Abstract
In the three domains of life, three biosynthetic pathways are known for putrescine. The first route is conversion of ornithine to putrescine by ornithine decarboxylase (ODC: SpeC), the second route is the conversion of arginine to agmatine by arginine decarboxylase (ADC: SpeA), followed by the conversion of agmatine to putrescine by agmatine ureohydrolase (AUH: SpeB), and the third route is the conversion of agmatine to N-carbamoylputrescine by agmatine deiminase (agmatine iminohydrolase, AIH), followed by the conversion of N-carbamoylputrescine to putrescine by N-carbamoylputrescine amidohydrolase (NCPAH). An extreme thermophile, Thermus thermophilus produces putrescine, although this bacterium lacks homologs for putrescine synthesizing pathways, such as ODC, AUH, AIH and NCPAH. To identify genes involved in putrescine biosynthesis in T. thermophilus, putrescine biosynthesis was examined by disruption of a predicted gene for agmatinase (agmatine ureohydrolase), or by using purified enzyme. It was found that arginase (TTHA1496) showed an agmatinase activity utilizing agmatine as a substrate. These results indicate that this bacterium can use arginase for putrescine biosynthesis. Arginase is a major contributor to putrescine biosynthesis under physiological conditions. The presence of an alternative pathway for converting agmatine into putrescine is functionally important for polyamine metabolism supporting survival at extreme environments.
Risk-reducing salpingo-oophorectomy for Japanese women with hereditary breast and ovarian cancer: a single-institution 10-year experience
Authors: Nagashima Minoru , Ishikawa Tetsuya , Asami Yuka , Hirose Yusuke , Shimada Kanae , Miyagami Satoshi , Mimura Takashi , Miyamoto Shingo , Onuki Mamiko , Morioka Miki , Izumi Mikiko , Yoshida Reiko , Yamochi Toshiko , Taruno Kanae , Nakamura Seigo , Sekizawa Akihiko , Matsumoto Koji 
Published: March 2023

Abstract

Background
For women diagnosed with hereditary breast and ovarian cancer, the clinical guidelines recommend risk-reducing salpingo-oophorectomy at age 35–40 years or after completion of childbearing. However, there is limited information regarding the current status of risk-reducing salpingo-oophorectomy in Japan.

Methods
To clarify factors influencing decision-making for risk-reducing salpingo-oophorectomy among Japanese women diagnosed with hereditary breast and ovarian cancer and their clinical outcomes, we analyzed the medical records of 157 Japanese women with germline BRCA pathogenic variants (BRCA1 n = 85, BRCA2 n = 71 and both n = 1) at our institution during 2011–21. Specimens obtained from risk-reducing salpingo-oophorectomy were histologically examined according to the sectioning and extensively examining the fimbriated end protocol.

Results
The risk-reducing salpingo-oophorectomy uptake rate was 42.7% (67/157). The median age at risk-reducing salpingo-oophorectomy was 47 years. Older age, married state and parity were significantly associated with risk-reducing salpingo-oophorectomy (P &lt; 0.001, P = 0.002 and P = 0.04, respectively). History of breast cancer or family history of ovarian cancer did not reach statistical significance (P = 0.18 and P = 0.14, respectively). Multivariate analyses revealed that older age (≥45 years) and married state may be independent factors associated with risk-reducing salpingo-oophorectomy. Interestingly, the annual number of risk-reducing salpingo-oophorectomy peaked in 2016–17 and has increased again since 2020. The rate of occult cancers at risk-reducing salpingo-oophorectomy was 4.5% (3/67): ovarian cancer (n = 2) and serous tubal intraepithelial carcinoma (n = 1).

Conclusion
Age and marital status significantly affected decision-making for risk-reducing salpingo-oophorectomy. This is the first study to suggest possible effects of Angelina Jolie’s risk-reducing salpingo-oophorectomy in 2015 and the National Health Insurance introduced for risk-reducing salpingo-oophorectomy in 2020. The presence of occult cancers at risk-reducing salpingo-oophorectomy supports clinical guidelines recommending risk-reducing salpingo-oophorectomy at younger ages.