bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revisiting the bullwhip effect: how can AI smoothen the bullwhip phenomenon?
Authors: Weisz Eric , Herold David M. , Kummer Sebastian 
Published: December 2022

PurposeAlthough scholars argue that artificial intelligence (AI) represents a tool to potentially smoothen the bullwhip effect in the supply chain, only little research has examined this phenomenon. In this article, the authors conceptualize a framework that allows for a more structured management approach to examine the bullwhip effect using AI. In addition, the authors conduct a systematic literature review of this current status of how management can use AI to reduce the bullwhip effect and locate opportunities for future research.Design/methodology/approachGuided by the systematic literature review approach from Durach et al. (2017), the authors review and analyze key attributes and characteristics of both AI and the bullwhip effect from a management perspective.FindingsThe authors' findings reveal that literature examining how management can use AI to smoothen the bullwhip effect is a rather under-researched area that provides an abundance of research avenues. Based on identified AI capabilities, the authors propose three key management pillars that form the basis of the authors' Bullwhip-Smoothing-Framework (BSF): (1) digital skills, (2) leadership and (3) collaboration. The authors also critically assess current research efforts and offer suggestions for future research.Originality/valueBy providing a structured management approach to examine the link between AI and the bullwhip phenomena, this study offers scholars and managers a foundation for the advancement of theorizing how to smoothen the bullwhip effect along the supply chain.
Empirical analysis of Lean Six Sigma implementation barriers in healthcare sector using fuzzy DEMATEL approach: an Indian perspective
Authors: Singh Mahipal , Rathi Rajeev , Jaiswal Ajay , Manishbhai Shah Dhyey , Gupta Shaptarshi Sen , Dewangan Abhishek 
Published: December 2022

PurposeThe present study aims to explore the barriers to Lean Six Sigma (LSS) implementation in the healthcare sector and develop the ranking of finalized barriers using the Decision-Making Trial and Evaluation Laboratory (DEMATEL) approach under a fuzzy environment.Design/methodology/approachThe LSS barriers are identified through the literature review and validated by the expert's opinion and statistical analysis. A total of 124 experts were identified through the purposive sampling method for conducting this study. A questionnaire survey method is used to collect the data related to identified LSS barriers in the healthcare sector. The screened barriers are ranked through the Fuzzy DEMATEL approach.FindingsIn this study, a total of 21 barriers were identified with the help of a systematic literature review and screened 13 significant barriers by the expert opinions of healthcare personnel. The result reveals that “Lack of top management commitment and support, lack of awareness about LSS”, “resistance to culture change and inadequate resources emerges as the most critical barriers”. The prioritization of barriers facilitates the managers to make effective policies and guidelines for LSS implementation in healthcare organizations.Practical implicationsTo avoid LSS implementation failure, the practitioners and researchers need to focus on LSS barriers as per suggested ranking more conventionally and make plans and adoption policies accordingly.Originality/valueThis study is unique in terms of investigation and empirical analysis of LSS implementation barriers in the healthcare sector in the Indian context. The outcomes of the present study will help the managers of healthcare organizations to make the strategies and policies for LSS implementation as per the recommended LSS barriers.
Safety and efficacy of high‐dose clobetasol propionate 0.05% in cutaneous lichen planus
Authors: Melin Audrey , Bouchereau Sarah , Guelimi Robin , Bergqvist Christina , Condamina Morgane , Giraud‐Kerleroux Laura , Hirsch Gaëlle , Hua Camille , Wolkenstein Pierre , Skayem Charbel , Le Cleach Laurence 
Published: December 2022

AbstractCutaneous lichen planus is a highly pruritic dermatosis with an unmet need in its management. The aim of this study was to evaluate the short‐term effect and tolerance of high doses of clobetasol propionate 0.05% in cutaneous lichen planus. We conducted a single‐center retrospective cohort study from 2017 to 2021. All adults treated with high‐dose (>5 g/day) clobetasol propionate 0.05% for cutaneous lichen planus were included. Patients with less than 10% affected body surface area at initial presentation or who received concomitant systemic therapy were excluded. The primary endpoint was the rate of complete remission by week 16. Secondary endpoints included maximum daily and median cumulative doses, reduction in pruritus and occurrence of adverse events. Fifty‐seven patients, 60% female, with a mean age of 48 years (min–max,18–83) were included. Cutaneous lichen planus had been present for a median duration of 2 months at initial presentation (min–max, 1–4) and involved a median body surface area of 27%. Pruritus was reported by 55/57 (96%) patients. At week 16, 41/57 (72%) patients had achieved complete remission without treatment modification, among whom 25/41 (61%) had achieved it at week 6. The median daily and cumulative doses were, respectively, 20 g/day (IQR, 10–20) and 560 g (IQR, 320–925). Three patients experienced mild adverse events. No statistical association was demonstrated between the duration of the disease before treatment initiation and clinical response. In conclusion, high‐dose clobetasol propionate 0.05% seems to be an effective, well‐tolerated, and easy‐to‐implement treatment for cutaneous lichen planus.
TAPO in first‐line osimertinib therapy and continuation of osimertinib
Authors: Mimura Chihiro , Kaneshiro Kazumi , Fujimoto Shodai , Dokuni Ryota , Iwamoto Natsuhiko , Matsumura Kanoko , Hatakeyama Yukihisa , Kono Yuko , Tachihara Motoko 
Published: December 2022

AbstractBackgroundOsimertinib is associated with a relatively high frequency of drug‐induced interstitial lung disease (D‐ILD), and transient asymptomatic pulmonary opacities (TAPO) have been reported to occur during osimertinib administration. The frequency of TAPO during first‐line treatment and the pros and cons of osimertinib continuation is unknown.MethodsThis was a multicenter, retrospective study. The purpose of this study was to research the frequency of TAPO and to evaluate osimertinib continuation in first‐line therapy. We also evaluated progression‐free survival (PFS) including subgroup analysis.ResultsFrom August 2018 to December 2020, 133 patients were enrolled into the study. The median observation period was 23.2 months (0.3–48.3 months). Thirty patients (22.6%) experienced D‐ILD events, including 16 patients (12.1%) with CTCAE grade 1, five patients (3.8%) with grade 2, and nine patients (6.7%) with grade 3 and above D‐ILD. Among the patients with grade 1 D‐ILD, 11 cases (8.3%) of TAPO were observed, and all patients succeeded in osimertinib continuation. The TAPO images were characterized by localized patchy opacities (73%). The median PFS was 22.6 months (95% confidence interval [CI]: 17.8–28.7 months). Patients with TAPO had a significantly longer PFS than patients with non‐TAPO D‐ILD in the multivariate analysis.ConclusionsThis study showed that grade 1 D‐ILD might include TAPO and that patients with TAPO might have good PFS. We need to consider the possibility of osimertinib continuation when lung opacities appear.
Controlling the controls: what is negative pressure wound therapy compared to in clinical trials?
Authors: McMillan Hayley , Vo Uyen G. , Moss Jana‐Lee , Barry Ian P. , Bosanquet David C. , Richards Toby 
Published: December 2022

AbstractAimSurgical site infections (SSIs) are common following colorectal operations. Clinical trials suggest that closed incision negative pressure wound therapy (ciNPWT) may reduce SSIs compared to a ‘standard of care’ group. However, wound management in the standard of care group may vary. The aim of this review was to assess the control arms in trials of ciNPWT for potential confounding variables that could influence the rates of SSI and therefore the trial outcomes.MethodsA mapping review of the PubMed database was undertaken in the English language for randomized controlled trials that assessed, in closed surgical wounds, the use of ciNPWT compared to standard of care with SSI as an outcome. Data regarding wound care to assess potential confounding factors that may influence SSI rates were compared between the ciNPWT and standard of care groups. Included were the method of wound closure, control dressing type, frequency of dressing changes and postoperative wound care (washing).ResultsTwenty‐seven trials were included in the mapping review. There was heterogeneity in ciNPWT duration. There was little control in the comparator standard of care groups with a variety of wound closure techniques and different control dressings used. Overall standard of care dressings were changed more frequently than the ciNPWT dressing and there was no control over wound care or washing. No standard for ‘standard of care’ was apparent.ConclusionIn randomized trials assessing the intervention of ciNPWT compared to standard of care there was considerable heterogeneity in the comparator groups and no standard of care was apparent. Heterogeneity in dressing protocols for standard of care groups could introduce potential confounders impacting SSI rates. There is a need to standardize care in ciNPWT trials to assess potential meaningful differences in SSI prevention.
LQM10, a guanylhydrazone derivative, reduces nociceptive and inflammatory responses in mice
Authors: Noé João Paulo , de Souza‐Ferro Jamylle Nunes , da Silva‐Rodrigues Érica Erlanny , da Silva‐Júnior Edeildo Ferreira , Alexandre‐Moreira Magna Suzana , de Araújo‐Junior João Xavier , Barreto Emiliano 
Published: December 2022

AbstractIn the present study, we examined the antinociceptive and anti‐inflammatory activities of a guanylhydrazone derivative, (E)‐(3,5‐di‐tert‐butyl‐4‐hydroxybenzylidene)‐2‐guanylhydrazone hydrochloride (LQM10), in mice. The antinociceptive effect was determined by assessing behavioural responses in different pain models, while anti‐inflammatory activity was examined in carrageenan‐induced pleurisy. Intraperitoneal LQM10 administration reduced the acetic acid‐induced nociceptive behaviour, a phenomenon that was unaltered by pretreatment with yohimbine, atropine, naloxone or glibenclamide. In the formalin assay, LQM10 reduced nociceptive behaviour only in the second phase, indicating an inhibitory effect on inflammatory pain. LQM10 did not alter the pain latency in the hot plate assay and did not impact the locomotor activity of mice in the rotarod assay. In the carrageenan‐induced pleurisy assay, LQM10 treatment inhibited critical events involved in inflammatory responses, namely, leucocyte recruitment, plasma leakage and increased inflammatory mediators (tumour necrosis factor Like Properties of Chalchones and Flavonoid Derivatives [TNF]‐α and interleukin [IL]‐1β) in the pleural exudate. Overall, these results indicate that LQM10 exhibits antinociceptive effects associated with peripheral mechanisms and anti‐inflammatory activity mediated via a reduction in leucocyte migration and proinflammatory mediators, rendering this compound a promising candidate for treating pain and inflammatory process.
Distribution and geographic differences in stable isotope ratios of diamond squid Thysanoteuthis rhombus (Cephalopoda: Thysanoteuthidae) in Japanese waters
Authors: Ohshimo Seiji , Kodama Taketoshi , Tawa Atsushi , Tanaka Hiroshige , Tanaka Yosuke , Yasuhara Go , Tokuyasu Michihiro , Minami Yoichi 
Published: December 2022

AbstractDiamond squid Thysanoteuthis rhombus (Troschel, 1857), which can grow to a dorsal mantle length of ~100 cm in 1 year, is an important fisheries resource in subtropical and temperate waters worldwide. Around Japan, it is an important resource in the East China Sea, Sea of Japan, and western North Pacific Subtropical Gyre, including the Kuroshio area. It is not known if linkages occur between these habitats. To clarify the species distribution, we estimated the habitat of young squid using a generalized additive model based on trawl surveys and analyzed carbon and nitrogen stable isotope ratios (δ13C and δ15N) in tissue samples. Based on trawl observations, young squid were distributed around northeastern Taiwan and the Okinawa Islands in June–July and in the Sea of Japan and the Kuroshio extension areas in August–September. We observed ontogenetic changes in the stable isotope ratios. The δ15N values in large diamond squid (dorsal mantle length > 400 mm) were significantly lower in the Pacific than those in other areas. Considering that the δ15N of forage fish is low in the Pacific and high in the East China Sea and Sea of Japan, large diamond squid in the northwest Pacific presumably have two distinct habitats.
The association between nurse managers’ transformational leadership and quality of patient care: A systematic review
Authors: Alanazi Naif H. , Alshamlani Yousef , Baker Omar Ghazi 
Published: December 2022

AbstractAimTo examine and summarize the reported association of nurse managers’ transformational leadership and quality of patient care based on the perceptions of registered nurses.BackgroundTransformational leadership behaviors of nurse managers result in staff nurses’ satisfaction and retention and patient satisfaction. Patient safety and quality of care are vital to high‐performing healthcare organizations. Perceptions of registered nurses are important because nurses are frontline healthcare providers fundamental to patient safety and quality of care and are considered the final line of defense in preventing adverse events and errors and improving the safety of patients.Materials and methodsWe searched the CINAHL, ProQuest, PubMed, Science Direct, and Web of Science databases for evidence published between 2018 and 2022 in the English language. We adhered to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines in carrying out this meta‐analysis.ResultsNine quantitative studies were appraised using the Joanna Briggs Institute checklists and were included in the final review that involved a total sample of 3633 registered nurses. The included studies were reported across Asian, Middle East, and European countries within the past five years. The association between the transformational leadership behaviors of nurse managers and the quality of patient care was found in varying degrees (i.e., insignificant, weak, indirect, and strong direct association) based on the perceptions of registered nurses.ConclusionsThere is a direct and indirect association between the transformational leadership behaviors of nurse managers and the quality of patient care internationally. This association is influenced by confounding and mediating factors, including gender, organizational culture, structural empowerment, and job satisfaction.Implications for nursing and health policiesHealthcare organizations need to support nursing leaders to have a stronger transformational leadership style by considering several factors that influence their leadership to improve the quality of patient care their staff nurses provide at the bedside.
New atrial arrhythmia occurrence in single chamber implantable cardioverter defibrillator patients: A real‐world investigation
Authors: Patel Divyang , Rao Archana , Friedman Paul A. , Deshmukh Abhishek J. , Lande Jeff , Murphy Jeffrey A. , Brown Mark L. , Lexcen Daniel R. , Wilkoff Bruce L. 
Published: December 2022

AbstractIntroductionA current limitation of single chamber implantable cardioverter defibrillators (ICDs) is the lack of an atrial lead to reliably detect atrial fibrillation (AF) episodes. A novel ventricular based atrial fibrillation (VBAF) detection algorithm was created for single chamber ICDs to assess R‐R variability for detection of AF.MethodsPatients implanted with Visia AF™ ICDs were prospectively enrolled in the Medtronic Product Surveillance Registry from December 15, 2015 to January 23, 2019 and followed with at least 30 days of monitoring with the algorithm. Time to device‐detected daily burden of AF ≥ 6 min, ≥6 h, and ≥23 h were reported. Clinical actions after device‐detected AF were recorded.ResultsA total of 291 patients were enrolled with a mean follow‐up of 22.5 ± 7.9 months. Of these, 212 (73%) had no prior history of AF at device implant. However, 38% of these individuals had AF detected with the VBAF algorithm with daily burden of ≥6 min within two years of implant. In these 80 patients with newly detected AF by their ICD, 23 (29%) had a confirmed clinical diagnosis of AF by their provider. Of patients with a clinical diagnosis of AF, nine (39%) were newly placed on anticoagulation, including five of five (100%) patients having a burden >23 h.ConclusionsContinuous AF monitoring with the new VBAF algorithm permits early identification and actionable treatment for patients with undiagnosed AF that may improve patient outcomes.
Apolipoprotein E4 inhibits γ‐secretase activity via binding to the γ‐secretase complex
Authors: Sun Yang , Islam Sadequl , Gao Yuan , Nakamura Tomohisa , Zou Kun , Michikawa Makoto 
Published: December 2022

AbstractThe mechanisms of amyloid accumulation in familial Alzheimer's disease (FAD) and sporadic AD (SAD) are controversial. In FAD, mutations in presenilin (PSEN) impair γ‐secretase activity and lead to abnormal amyloid β–protein (Aβ) production, thereby increasing the Aβ42/40 ratio. SAD is postulated to be caused by decreased Aβ clearance of apolipoprotein E4 (APOE4), the strongest risk factor for SAD. However, whether intracellular APOE4 affects Aβ production is unclear. Using APOE3 and APOE4 knock‐in (KI) mouse brain and primary cultured fibroblasts from these mice, in this study, we demonstrated that APOE3 and APOE4 bind to the γ‐secretase complex and isoform‐dependently regulate its activity and Aβ production. We found that Aβ40 levels and γ‐secretase activity were higher in APOE knockout mouse brain than in wild‐type mouse brain. APOE4‐KI fibroblasts had significant lower Aβ levels and γ‐secretase activity but higher Aβ42/40 ratio compared with APOE3‐KI cells, indicating that APOE4‐KI reduces Aβ production by inhibiting γ‐secretase activity. Interestingly, the levels of γ‐secretase complex bound to APOE4 are higher than those bound to APOE3, and the levels of γ‐secretase complex in the brain and fibroblasts of APOE4‐KI mice were higher than those of APOE3‐KI mice. Taken together, our findings demonstrate that intracellular APOE4 inhibits Aβ production, more preferentially inhibits Aβ40 production, and thereby induces an increase in the Aβ42/40 ratio via binding to the γ‐secretase complex. These results suggest a novel mechanism in which intracellular APOE4 contributes to the pathogenesis of SAD by inhibiting γ‐secretase activity.image
Exploring the linkage between family financial struggle and children's bullying victimization: Implications for nursing and psychotherapeutic practices
Authors: Hong Jun Sung , Choi Jungtae , O'Donnell Lisa A. , Espelage Dorothy L. , Albdour Maha , Wu Chi‐Fang 
Published: December 2022

AbstractPurposeA few studies have found that children whose families are economically disadvantaged and financially struggling are at an elevated risk of victimization by their peers. However, extant research is largely descriptive. To address this gap, this study empirically tested the proposed pathways from family financial struggle to children's bullying victimization, including the role of barriers to healthcare access in this association using a nationally representative sample.Design and MethodsThe study utilizes the 2016 National Survey of Children's Health, a survey of a cross‐sectional, weighted probability sample of US children (ages 0–17 years) living in 50 states and the District of Columbia, and their caregivers. The sample used for the current study included 14,374 racially and ethnically diverse caregivers of children, aged 6–11 years.ResultsPositive significant associations between family financial struggle and children's bullying victimization, and between financial struggle and barriers to healthcare access were found. Barriers to healthcare access mediated the association between family financial struggle and bullying victimization.Practice ImplicationsGiven the documented effects of bullying victimization on children, findings point to the importance of developing psychotherapeutic practices that are appropriate for children who are flagged as “high‐risk.”
Do brachycephaly and nose size predict the severity of obstructive sleep apnea (OSA)? A sample‐based geometric morphometric analysis of craniofacial variation in relation to OSA syndrome and the role of confounding factors
Authors: Daboul Amro , Krüger Markus , Ivanovska Tatyana , Obst Anne , Ewert Ralf , Stubbe Beate , Fietze Ingo , Penzel Thomas , Hosten Norbert , Biffar Reiner , Cardini Andrea 
Published: December 2022

SummaryObstructive sleep apnea is a common disorder that leads to sleep fragmentation and is potentially bidirectionally related to a variety of comorbidities, including an increased risk of heart failure and stroke. It is often considered a consequence of anatomical abnormalities, especially in the head and neck, but its pathophysiology is likely to be multifactorial in origin. With geometric morphometrics, and a large sample of adults from the Study for Health in Pomerania, we explore the association of craniofacial morphology to the apnea–hypopnea index used as an estimate of obstructive sleep apnea severity. We show that craniofacial size and asymmetry, an aspect of morphological variation seldom analysed in obstructive sleep apnea research, are both uncorrelated to apnea–hypopnea index. In contrast, as in previous analyses, we find evidence that brachycephaly and larger nasal proportions might be associated to obstructive sleep apnea severity. However, this correlational signal is weak and completely disappears when age‐related shape variation is statistically controlled for. Our findings suggest that previous work might need to be re‐evaluated, and urge researchers to take into account the role of confounders to avoid potentially spurious findings in association studies.