bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of histopathological examination in aseptic revision total hip arthroplasty: a preliminary analysis
Authors: Rossmann Markus , Aljawabra Alaa , Mau Hans , Citak Mustafa , Gehrke Thorsten , Klatte Till Orla , Abdelaziz Hussein 
Published: September 2023

Introduction: The utility of a routine histopathological examination in aseptic revision total hip arthroplasty (THA) has not been well explored. We aim to describe the approach and present the results of histopathological examination, focusing on its clinical usefulness in the setting of aseptic revision THA. Method: We retrospectively reviewed 285 performed aseptic revision THA with available histopathological reports between 2015 and 2017 at a single institution. We described histopathological requests by the surgical team. Preoperative diagnoses, intraoperative findings, as well as histopathology and culture results were analysed. Results: 13 painful THAs (4.5%) had preoperatively unknown diagnoses. In 10 of them, potential causes of pain were intraoperatively identified. Histopathology confirmed these findings in 8 THAs. 19 THAs (6.7%) revealed unexpected positive cultures (UPC). Histopathology was negative for infection in 18 of them. Among 16 consultants, 3 surgeons requested histopathology in 47% of the cases (130/285), usually to exclude infection (101/285; 35%). Documentation for tissue sample location was lacking in 51% (145/285), and for question asked by the surgeon in 47% (135/285). Conclusions: Histopathology is deemed a useful confirmatory tool in the context of ruling out infection in UPCs, and in documenting intraoperative findings in painful THAs with unknown preoperative diagnoses. Importantly, the approach to requesting histopathology should be optimised. Further large-scale studies, including cost analyses, are warranted to explore the usefulness of histopathology in routine utility.
A hospital care coordination team intervention for patients with multimorbidity: A practice-based, participatory pilot study
Authors: Verhoeff Marlies , de Groot Janke F. , Peters-Siskens Hanneke , van Kan Erik , Vermeeren Yolande , van Munster Barbara C. 
Published: September 2023

ObjectivesThis study aims to develop and pilot a hospital care coordination team intervention for patients with multimorbidity and identify key uncertaintiesMethodsPractice-based, participatory pilot study with mixed methods in a middle-large teaching hospital. We included adult patients who had visited seven or more outpatient specialist clinics in 2018. The intervention consisted of an intake, a comprehensive review by a dedicated care coordination team, a consultation to discuss results and two follow-up appointments. We collected both quantitative and qualitative data.ResultsOut of 131 invited patients, 28 participants received the intake and comprehensive review. The intervention resulted in mixed outputs and short-term outcomes. Among the 28 participants, 21 received recommendations for at least two out of three categories (medication, involved medical specialists, other). Patients’ experienced effects ranged from no to very large effects. Key uncertainties were how to identify patients with a need for care coordination and the minimum of required data that can be collected during regular clinical care with feasible effort.DiscussionRecruitment and selection for hospital care coordination should be refined to include patients with multimorbidity who might benefit most. Outcomes of research and clinical care should align and first focus on evaluating the results of care coordination before evaluating health-related outcomes.
Variation of diagnosis and treatment of catheter-associated urinary tract infections: an online survey among caretakers involved
Authors: van Doorn Tess , Berendsen Sophie A. , Coolen Rosa L. , Scheepe Jeroen R. , Blok Bertil F. M. 
Published: September 2023

Background: The diagnosis of a clinically significant catheter-associated urinary tract infection (CAUTI) in patients performing clean intermittent catheterization (CIC) or with an indwelling catheter (IC) can be challenging. Objective: To get an insight into the variation of the used definition, diagnosis and management of CAUTIs by relevant healthcare workers in the Netherlands. Design: An online clinical scenario-based survey. Methods: The survey was built in Limesurvey and distributed to healthcare workers from randomly selected urology departments, rehabilitation departments/centres and general practice offices between January and May 2022. Questions regarding their field of experience, management strategies, used guidelines and two hypothetical cases with clinical scenarios of a possible CAUTI were included. Results: A total of 172 individuals participated, of which 112 completed the survey. In all, 32 individuals who completed the survey partially were also included. Participants consisted of 68 [44 urologists, 22 rehabilitation doctors (RDs) and 2 general practitioners (GPs)] doctors, 60 nurses (46 from the urology department and 14 from rehabilitation centres/departments) and 16 medical assistants (13 from urology department and 3 from GP offices). The majority consulted patients with an IC or on CIC on a daily/weekly or monthly basis. In all, 35 urologists (79.5%), 9 RDs (40.9%), 21 (45.7%) nurses in the urology department and 6 (42.9%) nurses from a rehabilitation department/centre indicated bladder irrigation as a treatment option for prevention/treatment of CAUTIs, treatment of symptoms or treatment of blockage of the catheter. In the clinical scenarios presented, treatment discrepancies were seen between subspecialties and healthcare workers. Various guidelines were named for the definition of CAUTIs. Conclusion: A considerable variation in diagnoses and management of CAUTIs between the healthcare workers involved was seen. Uniformity in diagnosing and managing CAUTIs, to prevent overtreatment and possible resistance to antibiotics, is advised. Suitable multidisciplinary guidelines are preferred.
The Effect of Do-It-Yourself Real-Time Continuous Glucose Monitoring on Glycemic Variables and Participant-Reported Outcomes in Adults With Type 1 Diabetes: A Randomized Crossover Trial
Authors: Sehgal Shekhar , Elbalshy Mona , Williman Jonathan , Galland Barbara , Crocket Hamish , Hall Rosemary , Paul Ryan , Leikis Robert , de Bock Martin , Wheeler Benjamin J. 
Published: September 2023

Aim: Real-time continuous glucose monitoring (rtCGM) has several advantages over intermittently scanned continuous glucose monitoring (isCGM) but generally comes at a higher cost. Do-it-yourself rtCGM (DIY-rtCGM) potentially has benefits similar to those of rtCGM. This study compared outcomes in adults with type 1 diabetes using DIY-rtCGM versus isCGM. Methods: In this crossover trial, adults with type 1 diabetes were randomized to use isCGM or DIY-rtCGM for eight weeks before crossover to use the other device for eight weeks, after a four-week washout period where participants reverted back to isCGM. The primary endpoint was time in range (TIR; 3.9-10 mmol/L). Secondary endpoints included other glycemic control measures, psychosocial outcomes, and sleep quality. Results: Sixty participants were recruited, and 52 (87%) completed follow-up. Glucose outcomes were similar in the DIY-rtCGM and isCGM groups, including TIR (53.1% vs 51.3%; mean difference −1.7% P = .593), glycosylated hemoglobin (57.0 ± 17.8 vs 61.4 ± 12.2 mmol/L; P = .593), and time in hypoglycemia <3.9 mmol/L (3.9 ± 3.8% vs 3.8 ± 4.0%; P = .947). Hypoglycemia Fear Survey total score (1.17 ± 0.52 vs 0.97 ± 0.54; P = .02) and fear of hypoglycemia score (1.18 ± 0.64 vs 0.97 ± 0.45; P = .02) were significantly higher during DIY-rtCGM versus isCGM. Diabetes Treatment Satisfaction Questionnaire status (DTSQS) score was also higher with DIY-rtCGM versus isCGM (28.7 ± 5.8 vs 26.0 ± 5.8; P = .04), whereas diabetes-related quality of life was slightly lower (DAWN2 Impact of Diabetes score: 3.11 ± 0.4 vs 3.32 ± 0.51; P = .045); sleep quality did not differ between the two groups. Conclusion: Although the use of DIY-rtCGM did not improve glycemic outcomes compared with isCGM, it positively impacted several patient-reported psychosocial variables. DIY-rtCGM potentially provides an alternative, cost-effective rtCGM option.
Impact on mental health, disease management, and socioeconomic modifications in hematological patients during the COVID-19 pandemic in Italy
Authors: De Muro Marianna , Janssen Annelot Julia , Amadori Sergio , de Fabritiis Paolo , Sabatino Dante , Niscola Pasquale , Torti Lorenza , Trawinska Malgorzata Monika , Tesei Cristiano , Bombaci Felice , Tarricone Mario , Bocchia Monica , Fava Carmen , Galimberti Sara , Iurlo Alessandra , Luciano Luigia , Abruzzese Elisabetta 
Published: September 2023

Background: Hematological patients are a highly vulnerable population with an increased risk of developing severe COVID-19 symptoms due to their immunocompromised status. COVID-19 has proven to cause serious mental health issues, such as stress, anxiety, and depression in the general population. However, data on the psycho-social impact of COVID-19 on hematological patients are lacking. Objectives: This study aims to examine the psychological well-being of hematological patients in Italy during the initial period of the COVID-19 pandemic. Furthermore, it seeks to explore the association between modifications in the management of hematological diseases and employment status of these patients during the COVID-19 pandemic and the resulting mental health outcomes. Design and Methods: A survey using the DASS-21 questionnaire was administered to 1105 hematological patients. Data analysis was conducted using the R software, and logistic regression analysis was performed to predict the association between hematological patient/general population and employment status with DASS scores. Results: The hematological patient population reported significantly higher levels of depression (OR 0.947, 95% CI 0.966–0.982, p < 0.001), anxiety (OR 0.948, 95% CI 0.939–0.958, p < 0.001), and stress (OR 0.984, 95% CI 0.977–0.992, p < 0.001) compared with the general population. A significant relationship has been found in stress between employed and unemployed patients (OR 1.015, 95% CI 1.000–1.030, p = 0.044), as well as in the control group (OR 1.024, 95% CI 1.010–1.039, p = 0.001). In addition, employment status is significantly related to depression, anxiety, and stress in both the hematological patient group and the general population. Conclusion: During the initial phase of the COVID-19 pandemic, hematological patients had elevated levels of depression, anxiety, and stress compared with the general population. The delay in their treatment and employment status played a role in their mental health outcomes. These findings emphasize the importance of further research to gain deeper insight into the long-term psychological effects and explore effective strategies for managing mental health in similar crises.
Of headlamps and marbles: A motivated perceptual approach to the dynamic and dialectic nature of fairness
Authors: Bashshur Michael R. , Barclay Laurie J. , Fortin Marion 
Published: September 2023

How do people perceive fairness? Recently, fairness scholars have raised important theoretical questions related to what information is used in fairness perceptions, why this information is emphasized, and how fairness perceptions can change over time. Integrating the Brunswikian lens approach with a motivated cognition perspective, we develop the Motivated Perceptual Approach (MPA) to highlight how people can be motivated to selectively perceive and weight cues to form fairness perceptions that align with their motives. However, these motives can change over time and through interaction with motivated others. By illuminating the dynamic and dialectic processes underlying fairness perceptions, the MPA sheds light on how people's fairness perceptions can be influenced by their own motives as well as socially constructed and negotiated through interactions with motivated others. Practical insights include how to effectively manage fairness perceptions over time and across perspectives. We conclude with a research agenda for advancing the fairness literature. Plain Summary Whether or not people perceive they (or others) have been treated fairly or are treating others fairly at work, has implications for a variety of important outcomes ranging from helping others (when people perceive fairness) to undermining supervisors, making plans to quit or punishing bad actors (when people perceive unfairness). Important questions remain, however, around how people come to these perceptions in the first place. How do they decide what is fair? A long time assumption has been that these perceptions are subjective and motivated; that “fairness is in the eye of the beholder.” Based on this assumption, two people who experience the same event may come away with very different fairness perceptions. This is a crucial insight that helps explain the significant disparities in perceptions of fairness between people. However, as a field, we seem to have strayed from that foundational assumption. In this paper, we revisit this premise to develop an approach describing how people collect and integrate information to inform their fairness perceptions, highlighting the particular role that their motives (what they want to perceive, e.g., that they are fair actors, that they are treated well by important others) shape what information they attend to and use in arriving at their perceptions of fairness. From this perspective we explain how fairness perceptions can change over time, explain and predict differences between perspectives (e.g., managers and employees), and provide guidance for developing practical interventions that can reduce these differences before they become intractable.
Exploring the Renewable Energy Linkages for SSEBased Organizations in India: Benefits of Scaling Up ‘Atmanirbhar Bharat’ at Microsocieties
Authors: Nag Tirthankar , Ganguly Boudhayan 
Published: September 2023

The Indian government initiated the Atmanirbhar Bharat Abhiyan to make its citizens ‘atmanirbhar’, or self-reliant. We argue that self-reliance can be achieved through self-sufficiency at the societal level. Next, we review the extant literature on self-sufficiency and theorize its linkages with social and solidarity economy (SSE) in the context of electric power generation. The participatory and democratic nature of governance in decision-making processes is one of the main principles of the SSE sector. Variations in democratic governance and inclusive participation in SSE depend on SSE structure. Subsequently, we move into the focus areas of the article, where the purpose is to explore the linkages between the development of SSE initiatives and sustainable development goals focused on environmental protection and sustainable production and consumption. Scaling up and solarizing agricultural pump sets have been good initiatives at addressing issues around agriculture, water and electricity requirement. This study explores SSE initiatives that address these issues and explores scaling up and linking with institutions and policies at the macro level. The study presents empirical evidence of such initiatives in the renewable energy sector. This article is expected to contribute to the existing literature on SSEs and offer insights on how scaling up SSEs can help in sustainable rural development, which would lead to self-sufficiency and subsequently self-reliance at a societal level. JEL Classifications: D71, Q20, P48
The Impact of Transformational Leadership Style on Nurses’ Job Satisfaction: An Integrative Review
Authors: Gebreheat Gdiom , Teame Hirut , Costa Emilia I 
Published: September 2023

Introduction The argument about whether leadership style affects nurses’ job satisfaction is centered around the impact of different leadership styles on the work environment and the quality of care provided by nurses. Therefore, this review was primarily aimed at assessing the impact of transformational leadership style on the job satisfaction of hospital nurses. Methods This is an integrative review conducted according to the Whittemore and Knafl's framework. Comprehensive literature searches were conducted in PubMed, MEDLINE, CINAHL, Web of Science, Research4Life, and APA PsychInfo. In addition, studies were included through hand-searching from different sources of grey literature and a reference list of identified articles. All English articles published between 2012 and 2023 reporting the impact of transformational leadership style on nurses’ job satisfaction were eligible for inclusion. Results Seventeen articles were included in the review, of which 16 were cross-sectional studies, while one was mixed. The majority ( n = 12) of the studies were conducted in at least two or more healthcare settings, with a total of 5841 nurses. Almost all ( n = 16) articles reported the positive influence of transformational leadership on nurses’ job satisfaction. In addition, the transformational leadership style was reported to have a positive impact on nurses’ intentions to stay at work, quality care, and patient outcomes. Conclusion By adopting a transformational leadership approach within clinical environments, there is a potential to boost nurses’ job satisfaction.
How I treat von Willebrand disorders in older adults
Authors: Poston Jacqueline N. , Kruse-Jarres Rebecca 
Published: September 2023

Abstract
von Willebrand disease (VWD) is the most common bleeding disorder and especially milder type 1 VWD might not be cared for in specialty clinics. VW factor levels rise with age, but the rise of these levels does not necessarily correlate with bleeding risk. A recent bleeding history combined with recent labs are important for hemostatic management decision during surgical interventions. Antifibrinolytics appear safe in the population of older adults, whereas desmopressin (DDAVP) should be used cautiously. Where needed, factor concentrates present a great treatment option. Acquired von Willebrand syndrome is vastly underrecognized, but likely to surface in the aging, especially in the setting of comorbidities, such as plasma-cell dyscrasias. Intravenous immunoglobulin can be an effective treatment in this scenario, but potentially increases thrombotic risk.
Elevated CDKN1A (P21) mediates β-thalassemia erythroid apoptosis, but its loss does not improve β-thalassemic erythropoiesis
Authors: Liang Raymond , Lin Miao , Menon Vijay , Qiu Jiajing , Menon Anagha , Breda Laura , Arif Tasleem , Rivella Stefano , Ghaffari Saghi 
Published: September 2023

Abstract
β-thalassemias are common hemoglobinopathies due to mutations in the β-globin gene that lead to hemolytic anemias. Premature death of β-thalassemic erythroid precursors results in ineffective erythroid maturation, increased production of erythropoietin (EPO), expansion of erythroid progenitor compartment, extramedullary erythropoiesis, and splenomegaly. However, the molecular mechanism of erythroid apoptosis in β-thalassemia is not well understood. Using a mouse model of β-thalassemia (Hbbth3/+), we show that dysregulated expression of the FOXO3 transcription factor is implicated in β-thalassemia erythroid apoptosis. In Foxo3−/−/Hbbth3/+ mice, erythroid apoptosis is significantly reduced, whereas erythroid cell maturation, and red blood cell and hemoglobin production are substantially improved even with elevated reactive oxygen species in double-mutant erythroblasts. However, persistence of elevated reticulocytes and splenomegaly suggests that ineffective erythropoiesis is not resolved in Foxo3−/−/Hbbth3/+. We found the cell cycle inhibitor Cdkn1a (cyclin-dependent kinase inhibitor p21), a FOXO3 target gene, is markedly upregulated in both mouse and patient–derived β-thalassemic erythroid precursors. Double-mutant p21/Hbbth3/+ mice exhibited embryonic lethality with only a fraction of mice surviving to weaning. Notably, studies in adult mice displayed greatly reduced apoptosis and circulating Epo in erythroid compartments of surviving p21−/−/Hbbth3/+ mice relative to Hbbth3/+ mice, whereas ineffective erythroid cell maturation, extramedullary erythropoiesis, and splenomegaly were not modified. These combined results suggest that mechanisms that control β-thalassemic erythroid cell survival and differentiation are uncoupled from ineffective erythropoiesis and involve a molecular network including FOXO3 and P21. Overall, these studies provide a new framework for investigating ineffective erythropoiesis in β-thalassemia.
Nonrelapse mortality after CAR T-cell therapy for large B-cell lymphoma: a LYSA study from the DESCAR-T registry
Authors: Lemoine Jean , Bachy Emmanuel , Cartron Guillaume , Beauvais David , Gastinne Thomas , Di Blasi Roberta , Rubio Marie-Thérèse , Guidez Stéphanie , Mohty Mohamad , Casasnovas Rene-Olivier , Joris Magalie , Castilla-Llorente Cristina , Haioun Corinne , Hermine Olivier , Loschi Michael , Carras Sylvain , Bories Pierre , Fradon Tom , Herbaux Charles , Sesques Pierre , Le Gouill Steven , Morschhauser Franck , Thieblemont Catherine , Houot Roch 
Published: September 2023

Abstract
CD19 chimeric antigen receptor (CAR) T cells can induce prolonged remissions and potentially cure a significant proportion of patients with relapsed/refractory large B-cell lymphomas. However, some patients may die of causes unrelated to lymphoma after CAR T-cell therapy. To date, little is known about the nonrelapse mortality (NRM) after CAR T-cell therapy. Using the French DESCAR-T registry, we analyzed the incidence and causes of NRM and identified risk factors of NRM. We report on 957 patients who received standard-of-care axicabtagene ciloleucel (n = 598) or tisagenlecleucel (n = 359) between July 2018 and April 2022, in 27 French centers. With a median follow-up of 12.4 months, overall NRM occurred in 48 patients (5.0% of all patients): early (before day 28 after infusion) in 9 patients (0.9% of all patients and 19% of overall NRM), and late (on/after day 28 after infusion) in 39 patients (4.1% of all patients and 81% of overall NRM). Causes of overall NRM were distributed as follows: 56% infections (29% with non–COVID-19 and 27% with COVID-19), 10% cytokine release syndromes, 6% stroke, 6% cerebral hemorrhage, 6% second malignancies, 4% immune effector cell associated neurotoxicities, and 10% deaths from other causes. We report risk factors of early NRM and overall NRM. In multivariate analysis, both diabetes and elevated ferritin level at lymphodepletion were associated with an increased risk of overall NRM. Our results may help physicians in patient selection and management in order to reduce the NRM after CAR T-cell therapy.