bluuebunny/crossref_metadata_2025_split huggingface dataset:
O CAMINHO COMO ELEMENTO ESTRUTURADOR DA CRONOTOPIA NA VIAGEM QUIXOTESCA
Authors: Romero Corzo José Antonio , Rodrigues Walace 
Published: December 2022

O objectivo deste artigo é apresentar a nossa análise qualitativa do caminho como um elemento estruturante da cronotopia na viagem quixotesca. Para tal, baseamos a nossa análise no estudo realizado pelo semioticista espanhol José María Paz Gago (1995). Destacamos aqui a estruturação em intriga da Primeira e Segunda Partes do "Quixote", através da descrição da sua macro-sequência global, micro-sequências e funções narrativas. Em conjunto, explicamos as características da viagem de aventuras de Dom Quixote e Sancho Panza, com base na solidariedade existente entre as dimensões temporal e espacial do romance de Cervantes. E, finalmente, expomos as formas como a poética realista do movimento na viagem de Dom Quixote está indissociavelmente ligada ao cronotopo do caminho.
Palavras-chave: Semiótica, narrativa, viagem, caminho, cronotopo.
MANAGERIAL ABILITY, INCOME SMOOTHING DAN EARNINGS INFORMATIVENESS: BUKTI DARI PASAR MODAL INDONESIA
Authors: Fuadi Fauzan , Mustika Ratu Dewi , Abdul Fanni Aulizza 
Published: December 2022

Hubungan antara perataan laba dan keinformatifan laba ditentukan oleh alasan mengapa perusahaan menggunakannya. Mengambil keuntungan dari adanya motif oportunistik dalam melakukan perataan laba di perusahaan Indonesia, penelitian ini menginvestigasi apakah perataan laba mengurangi tingkat keinformatifan laba. Penelitian ini memperluas literatur dengan mempertimbangkan apakah kecakapan manajerial dapat memperlemah hubungan antara perataan laba yang bersifat oportunistik terhadap keinformatifan laba. Penelitian ini menggunakan sampel 356 observasi perusahaan dan tahun yang terdaftar di Bursa Efek Indonesia (BEI) periode 2015 sampai 2018. Hasil penelitian ini menunjukkan bahwa perataan laba secara signifikan mengurangi keinformatifan laba dan hubungan tersebut diperlemah oleh manajer berkemampuan tinggi. Penelitian ini menunjukkan hasil yang konsisten setelah dilakukan uji ketahanan. Sementara penelitian sebelumnya pada topik perataan laba, keinformatifan laba dan kecakapan manajerial terutama berfokus pada negara maju, hanya ada sedikit bukti pada negara berkembang. Sejauh pengetahuan kami, penelitian ini adalah yang pertama menginvestigasi peran kecakapan manajerial dalam memitigasi dampak perataan laba pada keinformatifan laba dalam konteks Indonesia.
Citisiniclina no Tratamento Farmacológico da Cessação Tabágica: Uma Revisão Baseada na Evidência
Authors: Pereira Vicente Ana Filipa , Berezovska Trindade Lourenço Olena 
Published: December 2022

INTRODUÇÃO: O tabagismo traduz-se em elevada morbi-mortalidade. Deixar de fumar tem benefícios em qualquer idade. O objetivo desta revisão é determinar o nível de evidência da prescrição de citisiniclina (citisina) no tratamento farmacológico da cessação tabágica (CT).METODOLOGIA: Realizou-se a 9 de dezembro de 2021 uma pesquisa bibliográfica nas bases de dados de estudos publicados nos últimos 10 anos, em inglês e português, utilizando os termos MeSH: “cytisine” e “smoking cessation”. Para estrati?car o nível de evidência e a força de recomendação, foi utilizada a escala SORT da American Academy of Family Physicians.RESULTADOS: Foram encontrados 153 artigos, tendo sido selecionados 14 artigos: 2 meta-análises, 7 revisões sistemáticas e 5 ensaios clínicos controlados randomizados.CONCLUSÃO: Concluiu-se que a citisiniclina apresenta efeitos benéficos na CT, com efeitos secundários ligeiros, pelo que evidência atual permite recomendar a citisiniclina na terapêutica farmacológica da CT (nível de evidência 1, grau de recomendação A).
Infeções Urinárias em Doentes com Diabetes Mellitus Tipo 2 Tratados com Inibidores do SGLT2: Uma Revisão Baseada na Evidência
Authors: Rocha-Castro Carlos , Lopes Vaz Pedro , Pereira Gomes Carla 
Published: December 2022

INTRODUÇÃO: O mecanismo de ação dos inibidores do co-transportador de sódio-glicose 2 (iSGLT2) consiste no aumento da glicosúria. Existe evidência da associação entre a sua toma e a ocorrência de infeções genitais. Porém, a associação com infeções do trato urinário (ITU) não está bem estabelecida. Pretende-se analisar a evidência atual sobre a associação entre iSGLT2 em doentes com diabetes mellitus tipo 2 e a ocorrência de ITU.MÉTODOS: Pesquisadas normas de orientação clínica, meta-análises (MA), revisões sistemáticas e ensaios clínicos controlados e aleatorizados (ECCA) entre outubro de 2011 e outubro de 2021 na The National Institute for Health and Care Excellence, The Cochrane Library e PubMed. Utilizados os termos MeSH “urinary tract infection”, “sodium-glucose transporter 2 inhibitors” e “diabetes mellitus, type 2”. Para atribuição dos níveis de evidência (NE) foi utilizada a escala Strength of Recommendation Taxonomy, da American Academy of Family Physicians.RESULTADOS: Dos 331 resultados identificados, 6 cumpriram os critérios de inclusão: 5 ECCA e 1 MA. Todos classificados com NE 2. A evidência da associação entre a toma de iSGLT2 e ITU foi apenas demonstrada, de forma estatisticamente significativa, na MA e relativamente à dapagliflozina na dosagem de 10 mg.CONCLUSÃO: Os estudos apresentam resultados heterogéneos, inconsistentes e de qualidade moderada. Os iSGLT2 têm afirmado o seu lugar no tratamento de múltiplas patologias pelo que impera a realização de estudos dirigidos à ocorrência de efeitos adversos como a frequência de ITU. Devem ainda compreender amostras de maior dimensão, diferentes moléculas e posologias, para a obtenção de evidência robusta.
The Effect of The Addition of Chitosan and Calcium Silicate on The Characteristic of Bioplastics from Corn Starch
Authors: Jhon Ricky , Haryanto  
Published: December 2022

Plastic waste in Indonesia has an impact that has caused high levels of environmental pollution. The use of plastic in everyday life as a packaging continues to increase, causing plastic waste to increase day by day. Plastic waste derived from petroleum raw materials is difficult to decompose by microbes in the soil. Biodegradable plastics are plastics that can be degraded by microorganisms and are made from renewable materials. Research on the use of biodegradable plastic synthesis has been developed because it is environmentally friendly and renewable. Biodegradable plastic is an alternative material to replace conventional plastic packaging so as not to pollute the environment. Biodegradable plastic is made with natural polymers as the main ingredient so that it is easily digested by microorganisms. Corn starch is a waste from corn processing used by the food industry. The starch content in corn starch can be used to make biodegradable plastic. In this study, biodegradable plastic was synthesized from corn starch with chitosan and calcium silicate as filler and then glycerol as a plasticizer. The purpose of this study was to determine the variation of filler on the results of biodegradable plastics made. The characteristics of biodegradable were marked by the presence of Tensile Strength, Elongation and Biodegradibility tests according to SNI Standards. The highest Tensile Strength value was obtained for the Chitosan variation of 2.62 Mpa and for the Calcium Silicate Variation of 2.8 Mpa, then for the Elongation Value for the Chitosan and Calcium Silicate Variations in accordance with SNI standards, which was 10-40% and for the Biodegradability of Chitosan and Calcium Silicate Variations. Calcium Silicate about 35-40 days.
Pengembangan Media Interaktif Berbasis Android Berbantuan Ispring dan Website 2 APK Builder pada Materi Aritmatika Sosial
Authors: Safira Dede Vika Tsania , Marliani Dinda Sintia , Nasihah Dida Durotun , Nurmaulidiyah Novita , Mubarok Jajat Fajril , Ratnaningsih Nani 
Published: December 2022

Salah satu bagian penting dalam pembelajaran adalah penggunaan media pembelajaran. Pemahaman ide oleh siswa dapat ditingkatkan melalui penggunaan media interaktif yang tepat. Karena portabel dan lebih mudah digunakan, Android menjadi alat pembelajaran yang baik. Dengan menggunakan I-Spring dan APK Builder, penelitian ini mempunyai tujuan untuk membuat bahan ajar interaktif berbasis Android untuk materi aritmatika sosial kelas VII. Eksplorasi ini merupakan penelitian dengan menggunakan teknik pengembangan model Borg and Gall Procedural yang dimodifikasi dengan tahapan analisis kebutuhan, desain, validasi desain, revisi desain, uji coba produk, revisi produk dan produk akhir. SMP Negeri SATAP 3 Sodonghilir menjadi tempat penelitian ini. Temuan penelitian menunjukkan bahwa media interaktif yang dihasilkan dapat digunakan untuk mengajarkan materi Aritmatika Sosial.
PENGEMBANGAN PARIWISATA BERBASIS EDUECO TOURISM DI KABUPATEN RAJA AMPAT, PAPUA BARAT
Authors: Rasyid Risal , Karmila Mila , Kesaulya Hertine M 
Published: December 2022

ABSTRACTThis study aims to examine the concept of tourism development in Raja Ampat Regency. Tourism development is currently important for regions that have tourism potential, because in the last few decades the tourism sector is one sector that plays an important role in improving the country's economy. This study uses a mixed method, qualitative methods are used to identify the condition of tourism objects and formulate the concept of tourism development in accordance with their potential and see policies that support tourism development in Raja Ampat Regency, while the use of quantitative methods to analyze the number of visits and tourist demand using the method least square. The output of this research is the concept of tourism development in Raja Ampat Regency based on EduEco Tourism, this concept means that tourism activities in Raja Ampat focus on ecological concepts, especially on the balance of nature and the environment, and in tourism activities tourists can learn about biodiversity and tourism ecosystems in Raja Ampat.Keywords: Tourism, Raja Ampat, Tourism Concept ABSTRAKPenelitian ini bertujuan untuk mengkaji konsep pengembangan pariwisata di Kabupaten Raja Ampat. Pengembangan pariwisata saat ini penting dilakukan oleh daerah-daerah yang memiliki potensi wisata, karena dibeberapa dekade terakhir sektor pariwisata merupakan salah satu sektor yang memiliki peran penting terhadap peningkatan ekonomi negara. Penelitian ini menggunakan metode campuran kualitatif dan kuantitaif, metode kualitatif digunakan dalam mengidentifikasi kondisi obyek wisata dan merumuskan konsep pengembangan pariwisata sesuai dengan potensi yang dimiliki serta melihat kebijakan yang mendukung pengembangan pariwisata di Kabupaten Raja Ampat, sedangkan penggunaan penggunaan kuantitatif untuk menganalisis jumlah kunjungan dan permintaan wisatawan yang menggunakan metode least square. Luaran dari penelitian ini berupa konsep pengembangan pariwisata Kabupaten Raja Ampat yang berbasis EduEco Tourism, konsep ini berarti bahwa kegiatan pariwisata di Kabupaten Raja Ampat menitikberatkan pada konsep ekologis terutama pada keseimbangan alam dan lingkungan, dan dalam kegiatan pariwisata wisatawan dapat memperoleh pembelajaran mengenai keanekaragaman hayati dan ekosistem wisata di Raja Ampat.Kata Kunci: Pariwisata, Raja Ampat, Konsep Pariwisata
Endovascular Closure of Secondary Septal Defect in Children with Low Body Weight
Authors: Ditkivskyy Igor O. , Voloshyn Denys L. , Yermolovych Yuliia V. , Perepeka Iryna A. , Lazoryshynets Vasyl V. 
Published: December 2022

The aim. To assess the effectiveness and safety of transcatheter closure of a secondary atrial septal defect (ASD) using an occluder in symptomatic children weighing ≤10 kg.
Materials and methods. In the period from November 2014 to June 2021, on the basis of the National Amosov Institute of Cardiovascular Surgery of the National Academy of Medical Sciences of Ukraine, closure of secondary ASD using an occluder was performed in 18 patients, among them 13 women (72.2%) and 5 men (27.8%). Th e mean age of the patients was 18.94±9.44 months (the youngest patient was 12 months, the oldest was 4 years). The mean weight was 9.294±1.170 kg (6.4 kg to 10 kg), the mean Z-score was -1.7±1.5 (-4.6 to 0.46), the mean height was 80 cm (71 cm to 88 cm). According to the measurements by transesophageal echocardiography (TEE), the average size of the defects was 13.7 mm±3.6mm (the largest 18.0 mm, the smallest 6.0 mm).
Results and discussion. In our publication, the effectiveness of the method was 100% (18/18), while the world statistics show 94-95%. Th e frequency of complications was 5.6% (n=1). We suggest that this is associated with the use of a sizing balloon and careful selection of the device.
When choosing treatment tactics for symptomatic children weighing ≤10 kg, the decisive factor was the determination of the presence of edges and the size of the defect. Defects were considered suitable for closure, according to TEE data, when all margins of the defect were ≥4 mm, except for the aortic margin. Although the total length of the interatrial membrane was taken into account, it was not of decisive importance, since for most occluders with the presence of all edges, the fields of the implant could not interfere with the work of the anatomical structures of the heart. To determine the real size of the defect, we recommend a measuring balloon under TEE control.
The following devices were used to close the defect: MemoPart ASD occluder, Amplatzer Septal Occluder, LifeTech HeartR Occluder, LifeTech HeartR Multi-Fenestrated Atrial Septal Defect (MF-ASD) Occluder.

Conclusion. After the study, we are convinced that the endovascular method of closing a hemodynamically significant secondary ASD for the treatment of children with a body weight of ≤10 kg has proven to be an effective method, with successful implantation of the occluder in 100% of cases.
Extracranial Carotid Artery Aneurysms: 20-Year Experience of Surgical Management
Authors: Kobza Ihor I. , Mota Yuliya S. , Kobza Taras I. 
Published: December 2022

Extracranial carotid artery aneurysm (ECAA) is a rare vascularpathology with reported incidence of 0.2-5.0% of all carotid artery surgical interventions. Most of ECAAs remain clinically asymptomatic, however, they can manifest in neurological symptoms as transient ischemic attack or stroke. The presence of a pulsating formation, swallowing disorders, signs of compression of cranial nerves may beindicative of the aneurysm growth, which is associated with higher risk of thromboembolic complications and less oftenwith rupture. Surgical treatment is a method of choice in symptomatic patients or in cases of the aneurysm growth and includes resection with arterial reconstruction, ligation of the artery or endovascular intervention.
The aim. To improve the results of surgical treatment of ECAAs.
Materials and methods. The results of clinical examination, laboratory, instrumental, intraoperative observations were analyzed in 39 patients (35 [89.7%] men and 4 [10.3%] women) with 44 ECAAs, who were admitted to the Vascular Surgery Department of Lviv Regional Clinical Hospital for the period from 2003 to 2022. To conϐirm the diagnosis of ECAA, preoperative instrumental examination included duplex ultrasonography and multispiral computed tomography angiography.
Results. Etiological causes of ECAAs included: atherosclerosis (79.5%),ϐibromuscular dysplasia (7.7%), trauma (5.1%), previous operations in the neck region (5.1%) and infection (2.6%). The justiϐication of the choice of surgical tactics depended on the localization of aneurysm, concomitant carotid occlusive disease or pathological deviation of carotid arteries. Early results of surgical treatment were evaluated up to 30 days of the postoperative period. The postoperative complications included: transient ischemic attack in 1 (2.6%), ischemic stroke in 2 (5.1%), cranial nerve damages in 4 (10.3%), thrombosis of arterial reconstruction in 2 (5.1%), hematoma of postoperative wound in 4 (10.3%), infection of postoperative wound in 1 (2.6%) cases. Postoperative mortality was 2.6%.
Conclusion. ECAA is a rare clinical disease that requires an active surgical approach to reduce the risk of ischemic stroke. Reconstructive surgery of ECAAs is a highly effective method of treatment that allows to achieve satisfactory results and prevent the development of severe complications.
Fabry Disease, a Rare Disorder with Cardiac Manifestations. The Problem of Diagnosis and Treatment: a Literature Review
Authors: Rudenko Kostiantyn V. , Nevmerzhytska Lidiia O. , Unitska Olha M. , Danchenko Polina A. , Leiko Nadiia S. 
Published: December 2022

Fabry disease (FD) is an X-linked lysosomal storage disease caused by a mutation in the gene encoding α-galactosidase A and leads to reduced activity or complete absence of this enzyme, which causes the accumulation of globotriaosylceramide (Gb3) and its deacylated form (lyso-Gb3) in cells of the whole body. FD can occur both with multisystem manifestations, including damage to the nervous system, kidneys, and skin, and can affect only the heart. Cardiac involvement is a major cause of poor quality of life and death in patients with FD and an underrecognized cause of heart failure with preserved ejection fraction and ventricular arrhythmias in men over 30 years of age and women over 40 years of age. Cardiac damage begins at an early age, progresses subclinically until the appearance of significant symptoms, and usually manifests as leftventricular hypertrophy, mimicking hypertrophic cardiomyopathy.
After the introduction of enzyme replacement therapy, early recognition of FD and differential diagnosis with other causes of leftventricular hypertrophy have become crucial to limit the progression of the disease. Recent advances in the understanding of cardiac pathophysiology and imaging have improved diagnostic and therapeutic approaches to the cardiac manifestations of this pathology.
Modern achievements in the study of cardiac manifestations of FD have made it possible to significantly improve diagnostic and therapeutic approaches, in particular, in relation to the identification of pathogenetic mechanisms of organ damage and early disruption of their function. A better understanding of secondary pathogenic pathways, such as myocardial inflammation, may influence future therapeutic strategies and timely diagnosis of FD.
Delay in diagnosis and untimely initiation of treatment remain critical problems for many patients with FD, especially for patients with late-onset cardiovascular manifestations, in whom treatment effects may be more limited and ineffective.
Cooperation between specialists in genetic diseases and cardiologists remains important to identify patients before the appearance of cardiac symptoms in order to obtain maximum therapeutic effects.
Comparative Analysis of Early Postoperative Period in Patients with Total Arterial Revascularization and Conventional Coronary Artery Bypass Grafting
Authors: Rudenko Nadiya M. , Pukas Oleksandr Yu. 
Published: December 2022

The use of total arterial myocardial revascularization in patients with multivessel lesions of the coronary arteries has a number of advantages, namely the duration of functioning or patency of the grafts. The level of total arterial myocardial revascularization implementation in developed and developing countries remains quite low.
The aim. Based on the analysis of our own experience, to determine the influence of the technique of total arterial revascularization on the frequency of complications in the early postoperative period.
Materials and methods. From February 22, 2016 to December 24, 2020, 390 consecutive patients were operated at the Ukrainian Children’s Cardiac Center. The patients were divided into two groups: participants of the group I underwent total arterial myocardial revascularization, and those includedin the group II underwent conventional coronary artery bypass grafting (CABG). The inclusion criteria were: ischemic heart disease, stable angina or exertional angina, multivascular coronary artery disease, absence of valvular pathology.
Results. There was zero 30-day mortality in both groups. The frequency of postoperative bleeding was higher in group II and amounted to 1.6%. Surgical wound complications (infection) were also more common in the group II: 1.2% versus 0.69% (p=0.906) in the group I. Similarly, laboratory parameters such as the level of creatine kinase-MB were almost identical.
Conclusions. Total arterial myocardial revascularization is a safe method with good immediate results. The frequency of complications in total arterial myocardial revascularizationdoes not differ from that in conventional CABG. For a wider application of the total arterial myocardial revascularization,it is necessary to continue toconduct studies of the remote postoperative period.
Vrednovanje slikovnog sadržaja u povijesnim novinama na primjeru Jastrebarskih novina
Authors: Štefanac Tamara 
Published: December 2022

Cilj. Ciljevi rada jesu prikazati moguće postupke vrednovanja slikovnog sadržaja u novinama i razmotriti njegove načine opisa i preformatiranja u suvremenoj praksi baštinskih ustanova.
Metodologija. Istraživanje je provedeno na uzorku Jastrebarskih novina (1964.– 1991.) i to kroz analizu povijesnog i suvremenog konteksta izlaženja i korištenja novina te kvantitativnu i kvalitativnu analizu sadržaja.
Rezultati. Slikovni prilozi u novinama i elementi njihovog graﬁčkog oblikovanja sadržajno su važni i često su neodjeljivi od tekstualnih priloga. Društveno-politički kontekst i propagandni diskurs slikovnih priloga u Jastrebarskim novinama od manjeg je značaja u odnosu na njihovu važnost kao izvora za bolje razumijevanje povijesti zavičaja i lokalne svakodnevice. Prilikom preformatiranja novina u kojima su slikovni prilozi vrednovani kao značajni, potrebno je uzeti u obzir njihove vizualne elemente.
Originalnost. Ovim radom potvrđena je nužnost vrednovanja pojedinačnog naslova novina u njihovom povijesnom i suvremenom kontekstu te iz aspekta slikovnog sadržaja. Također se preispituju odgovarajuće metode preformatiranja i zalaže se za induktivan i analitički pristup prilikom prenošenja svih oblika sadržaja na druge medije. Prema trenutnim spoznajama, ovaj rad prvi put donosi sadržajnu analizu slikovnih priloga utemeljenu u kontekstualnoj analizi lokalnih novina te prikazanu kroz prizmu politika vrednovanja i praksi preformatiranja slikovnog sadržaja.