bluuebunny/crossref_metadata_2025_split huggingface dataset:
Procesos avanzados de oxidación usando peróxido de hidrogeno activado con diferentes catalizadores para tratamiento de lixiviado de relleno sanitarios
Authors: Cadavid Salazar Angie Stephanie , Rivera Vergara Jeinner Giosephy , Becerra Moreno Dorance 
Published: June 2023

La mayor complicación ambiental que presenta la disposición final de los residuos sólidos urbanos es como se desarrolle el método que se use; como es el caso de los rellenos sanitarios, cuya problemática radica en la excesiva producción de lixiviado los cuales son producidos por la degradación de los desechos y factores ambientales. En los últimos años los PAOs, se han convertido en una opción viable como tratamiento y se destacan debido a sus ventajas en la eficiencia de oxidación, velocidades de reacción rápidas y oxidación completa. No obstante tratamientos como peroxono necesita grandes cantidades de químicos para producir el aumento necesario de OH, lo cual hace que este proceso no sea económicamente tan viable; a diferencia del proceso Fenton, el cual en condiciones ambientales es una técnica muy eficiente. Con relación a los procesos Fenton y Photo-Fenton, los estudios demuestran que este último produce menos cantidad de lodos, consume menos hierro y la disminución de la DQO es más eficiente. Este artículo presenta los PAOs, basados en peróxido de hidrogeno donde se estudió la eficacia de estos tratamientos aplicados a lixiviados.
Gender Disparities in Dropping out of High School Students and their Level of Depression
Authors: Salim Airin , Sultana Rehana , Akhter Syeda Sharmina , Azim Sabrina Fahmida , Hoshen Md Minuddin , Islam Md Zakirul 
Published: June 2023

Background: A drop-out can be defined as a child who enrols in school but fails to complete the relevant level of the educational cycle. It is usually associated with non-enrolment and a lower percentage of girls than boys in the school system. High school dropouts are more likely to be on welfare, have poorer health, have reduced intergenerational mobility, become teenage parents, unemployed, depressed, have substance abuse problems, engage in violent behaviours, and end up incarcerated. Adolescent depression is a mental and emotional disorder affecting adolescents and teens. According to WHO, globally depression is the number one cause of illness and disability in adolescent age group. Depression increases a teen’s risk for attempting suicide by 12 times and 30% of teens with depression also develop a substance abuse problem.
Objective: To find out the gender disparities in dropping out of high school students and their level of depression.
Methodology: This cross-sectional study was done in Adarsha Sadar, Cumilla, Bangladesh in between January 2014 to December 2014. Study sample was 339 adolescents of 13-19 years of that area. By purposive sampling technique data were collected through a pretested, semi-structed, interview questionnaire. Back Depression Inventory scale was used to assess the level of depression.
Results: Proportion of male drop out adolescent was 54% and female drop out adolescents 46%. 44.5% adolescents had depression and a positive association was found between adolescent depression and dropping out from high school.
Conclusions: There is an apparent gender gap among the high school dropouts, with more male adolescents dropping out than females. A positive association was found between the high school dropouts and the development of adolescent depression.
Eastern Med Coll J. Jan 2023; 8 (1), 1-5
PENGEMBANGAN KEMASAN DENGAN MENGGUNAKAN APLIKASI CANVA PADA UMKM KOPI 919
Authors: Rahmat Rahmat , Anastasia Anastasia 
Published: June 2023

Dunia bisnis akan selalu dihadapkan dengan perubahan, ini disebabkan oleh banyak faktor seperti tingginya daya saing antar perusahaan dan tingginya kemauan masyarakat akan perubahan produk agar bisa semakin praktis untuk digunakan.. Sebuah perusahaan harus bisa mengikuti perkembangan zaman, salah satu caranya yaitu dengan melakukan pengembangan kemasan. UMKM Kopi 919 adalah sebuah bisnis yang terletak di Perumahan Buludatu Blok B No.5. Kemasan yang digunakan UMKM 919 masih sangat kuno dan terkesan ketinggalan zaman sehingga peneliti akan mengembangkan kemasannya yang meliputi 5 aspek penting yaitu bentuk kemasan, bahan kemasan, warna, font dan merek. Tujuan dari penelitian ini adalah untuk mengetahui proses tahapan pengembangan produk pada Kopi 919 dan juga menciptakan kemasan kopi yang sedang trend dengan menggunakan aplikasi canva. Penelitian ini dilakukan selama kurang lebih empat bulan yaitu dari bulan April 2022 hingga Agustus 2022 dan melalui 3 tahap prosedur penelitian yaitu penciptaan ide kemasan, penyaringan ide dan pengembangan kemasan. Penelitian ini menggunakan jenis data berupa data kualitatif. Teknik pengumpulan data dalam penelitian ini dilakukan dengan observasi (pengamatan), interview (wawancara) dan dokumentasi. Hasil penelitian menunjukkan bahwa standing pouch berbahan aluminium foil adalah kemasan yang cocok untuk kopi bubuk dan disukai oleh masyarakat. Selain itu, masa penyimpanan, logo/merek, berat bersih dan komposisi adalah informasi yang dibutuhkan masyarakat serta warna yang cocok untuk produk kopi bubuk adalah coklat dan hitam.
Effect of eye rubbing on corneal biomechanical properties in myopia and emmetropia
Authors: Li Xia , Wei Anji , Yang Yujing , Hong Jiaxu , Xu Jianjiang 
Published: June 2023

Purpose: To investigate short-term changes in corneal biomechanical properties caused by eye rubbing in myopia and emmetropia and compare the different responses between the two groups.Methods: This was a prospective observational study of 57 eyes of 57 healthy subjects aged 45 years and younger. The participants were divided into myopia and emmetropia groups. All the subjects underwent eye rubbing by the same investigator using the same technique. Biomechanical parameters were recorded using the Corvis ST device before and after 1 min of eye rubbing. One week later, all the participants underwent the test again. Statistical methods were employed to compare the differences between the data from before and after the 1 min of eye rubbing and demonstrate the different responses of the two groups.Results: After 1 min of eye rubbing, smaller SP-A1 (p &lt; 0.001), higher deformation and deflection amplitudes (p &lt; 0.001, p = 0.012), higher peak distances (p &lt; 0.001), earlier A1 times (p &lt; 0.001), faster velocities (p &lt; 0.001), and lower maximum inverse radii (p = 0.004) were observed. According to the automatic linear modeling analysis, the refractive states (B = −5.236, p = 0.010) and biomechanically corrected intraocular pressure (bIOP) (B = 0.196, p = 0.016) had influenced a decrease in the stiffness parameter at the first applanation (SP-A1). The central corneal thickness (CCT) had decreased only in the myopia group (p = 0.039). The change of SP-A1 in amplitude was larger in the myopia group than in the emmetropia group (p &lt; 0.001). All the parameters returned to the baseline level 1 week later.Conclusion: Eye rubbing appears to alter corneal biomechanical properties temporarily and make the cornea softer, especially for myopic young patients.
Yolk@Wrinkled-double shell smart nanoreactors: new platforms for mineralization of pharmaceutical wastewater
Authors: Habibi Zare Masoud , Mehrabani-Zeinabad Arjomand 
Published: June 2023

Nanomaterials with “yolk and shell” “structure” can be considered as “nanoreactors” that have significant potential for application in catalysis. Especially in terms of electrochemical energy storage and conversion, the nanoelectrode has a large specific surface area with a unique yolk@shell structure, which can reduce the volume change of the electrode during the charging and discharging process and fast ion/electron transfer channels. The adsorption of products and the improvement of conversion reaction efficiency can greatly improve the stability, speed and cycle performance of the electrode, and it is a kind of ideal electrode material. In this research, heterojunction nanoreactors (FZT Y@WDS) Fe3O4@ZrO2-X@TiO2-X were firstly synthesized based on the solvothermal combined hard-template process, partial etching and calcination. The response surface method was used to determine the performance of the FZT Y@WDS heterojunction nanoreactors and the effects of four process factors: naproxen concentration (NAP), solution pH, the amount of charged photocatalyst, and the irradiation time for photocatalytic degradation of NAP under visible light irradiation. To maximize the photocatalytic activity, the parameters of the loaded catalyst, the pH of the reaction medium, the initial concentration of NAP, and the irradiation time were set to 0.5 g/L, 3, 10 mg/L, and 60 min, respectively, resulting in complete removal of NAP and the optimum amount was calculated to be 0.5 g/L, 5.246, 14.092 mg/L, and 57.362 min, respectively. Considering the promising photocatalytic activity of FZT Y@WDS under visible light and the separation performance of the nanocomposite, we proposed this photocatalyst as an alternative solution for the treatment of pharmaceutical wastewater.
Incidence and predictors of hemodynamic compromise due to high-grade AV block after TAVI
Authors: Weferling Maren , Lan Cheong Wah Stefan , Fischer-Rasokat Ulrich , Hain Andreas , Renker Matthias , Charitos Efstratios I. , Liebetrau Christoph , Treiber Julia , Choi Yeong-Hoon , Hamm Christian W. , Kim Won-Keun 
Published: June 2023

BackgroundHigh-grade AV block (HAVB) is the most frequent adverse event after transcatheter aortic valve implantation (TAVI). In rare cases, HAVB is associated with hemodynamic compromise (HC) followed by syncope or application of cardiopulmonary resuscitation (CPR), but data on this severe complication are scarce. The aim of the present study was to investigate the incidence and predictors of HC due to HAVB in patients undergoing TAVI.MethodsIn this retrospective analysis of 4,602 TAVI cases between 2010 and 2022, 466 developed HAVB. Baseline characteristics and procedural and postprocedural findings were compared for patients with HC versus those without. Univariate and multivariable regression analyses were used to investigate independent predictors of HC.ResultsForty-nine of 466 patients (10.5%) had HC due to HAVB after TAVI. Patients with HC had a longer hospital stay [10 (8–13) vs. 13 (9–18) days; p &lt; 0.001], more frequent peripheral artery disease (PAD) (28.6% vs. 15.1%; p = 0.016), and lower hemoglobin levels [11.8 (±) vs. 12.5 (±) g/dl; p = 0.006]. In the HC group, HAVB onset post-TAVI was delayed compared with the non-HC group [2 (1–4) vs. 1 (0–3) days; p &lt; 0.001]. Before HAVB onset, patients in the HC group more frequently developed post-TAVI delirium [18 (4.6%) vs. 11 (25.0%); p &lt; 0.001]. In univariate regression analysis, PAD, hemoglobin, procedural time, contrast agent volume, and post-TAVI delirium were significant predictors of HC. After adjustment, only post-TAVI delirium and contrast agent volume remained independent predictors [OR 3.22 (95% CI: 1.05–9.89); p = 0.042 and OR: 1.01 (95% CI: 1.0–1.01); p = 0.04, respectively].ConclusionHC due to HAVB after TAVI occurred in over 10% of cases. Development of post-TAVI delirium and contrast agent volume are independent predictors of this severe complication.
Short-term effect of beinaglutide combined with metformin versus metformin alone on weight loss and metabolic profiles in obese patients with polycystic ovary syndrome: a pilot randomized trial
Authors: Wen Qing , Fang Song , Liang Yanjing , Tian Yuting , Chen Yiding , Yuan Jun , Chen Qiu 
Published: June 2023

ObjectiveTo observe the effect of beinaglutide combined with metformin versus metformin alone on weight loss and metabolic profiles in obese patients with polycystic ovary syndrome(PCOS).MethodsA total of 64 overweight/obese women with PCOS diagnosed via the Rotterdam criteria were randomly assigned to metformin(MET) 850 mg twice a day(BID) or combined MET 850 mg BID with beinaglutide (COMB) starting at 0.1mg three times a day(TID)and increasing to 0.2mg TID two weeks later. The main endpoints were changes in anthropometric measurements of obesity. Glucose and lipid metabolic, gonadal profiles, and antral follicle count changes as secondary outcomes were also observed.Results60(93.75%) patients completed the study. In terms of lowering weight, body mass index (BMI),waist circumference(WC) and waist to height ratio(WHtR), COMB treatment outperformed MET monotherapy. Subjects in the COMB arm lost weight 4.54±3.16kg compared with a 2.47±3.59kg loss in the MET arm. In the COMB group, BMI,WC and WHtR were reduced significantly compared with that in the MET group, respectively. COMB therapy is also more favorable in the reduction of fasting insulin(FINS), total testosterone(TT), and homeostasis model assessment–insulin resistance(HOMA-IR) when compared to MET therapy. Antral follicle count and ovarian volume were non-significantly changed in both groups.The most frequent side effects in both groups were mild and moderate digestive symptoms. Itching and induration at the injection site were reported with COMB treatment.ConclusionShort-term combined treatment with beinaglutide and metformin appears superior to metformin monotherapy in lowering body weight, BMI, WC,WHtR and improving insulin sensitivity and androgen excess in women with PCOS and obesity, with tolerable adverse events.Clinical trial registrationhttps://www.chictr.org.cn/listbycreater.aspx, identifier ChiCTR2000033741.
Performance evaluation of MODIS and VIIRS satellite AOD products over the Indian subcontinent
Authors: Payra Swagata , Sharma Ajay , Mishra Manoj Kumar , Verma Sunita 
Published: June 2023

In the present study, the first systematic performance evaluation of aerosol optical depth (AOD) products retrieved using two satellite sensors i.e., Visible Infrared Imaging Radiometer Suite (VIIRS) and Aqua-Moderate-Resolution Imaging Spectroradiometer (MODIS) is carried out over India. We have used ground-based AOD from AERONET at 550 nm wavelength for inter-comparison with MODIS Aqua version C6.1 (C061) Deep Blue (DB) aerosol product and VIIRS/SNPP collection version 1.1 (V1.1) DB aerosol product over the time span of 7-year (2014–2020) observation periods. For validation, the average value of satellite pixels falling within the box of 50 Km x 50 Km keeping the AERONET station at the center is retrieved. The average daily data from the AERONET sun photometer (2014–2019) were obtained within ±15 min of satellite overpass time. Statistical parameters like correlation coefficient (R), RMSE, MAE, and RMB were calculated. The uncertainty of satellite AOD is evaluated using an envelope of Expected Error (EE = ±0.05 + 0.15 AOD for land). Statistical analysis shows that the MODIS AOD product outperforms VIIRS-retrieved AOD. The AOD retrieved from both sensors yields a high correlation (0.86—Jaipur, 0.79—Kanpur, 0.84—Gandhi College, and 0.74—Pune for MODIS and 0.75—Jaipur, 0.77—Kanpur, 0.49—Gandhi College, and 0.86—Pune for VIIRS) and low MAE (0.12—Jaipur, 0.20—Kanpur, 0.15—Gandhi College, and 0.09—Pune for MODIS and 0.13—Jaipur, 0.13—Kanpur, 0.26—Gandhi College, and 0.10—Pune for VIIRS). Other statistical measures such as RMSE, RMB, and P also suggest similar performance. More than 66% of the total data fall within the range of EE for both the satellite products at each station. Spatial comparison exhibits the same AOD pattern seasonally as well as annually having a minimum bias from −0.3 to +0.3 between MODIS and VIIRS. Slight underestimation and overestimation are observed in all the stations by MODIS, whereas VIIRS continuously underestimates AOD with increase in optical depth, suggesting improvements in the aerosol model and surface reflection in retrieval. Overall, the comparison of ground AERONET AOD reveals better accuracy of MODIS AOD with that of VIIRS satellite datasets over India.
Case report: Sex-specific characteristics of epilepsy phenotypes associated with Xp22.31 deletion: a case report and review
Authors: Wu Yi , Wu Dan , Lan Yulong , Lan Shaocong , Li Duo , Zheng Zexin , Wang Hongwu , Ma Lian 
Published: June 2023

Deletion in the Xp22.31 region is increasingly suggested to be involved in the etiology of epilepsy. Little is known regarding the genomic and clinical delineations of X-linked epilepsy in the Chinese population or the sex-stratified difference in epilepsy characteristics associated with deletions in the Xp22.31 region. In this study, we reported two siblings with a 1.69 Mb maternally inherited microdeletion at Xp22.31 involving the genes VCX3A, HDHD1, STS, VCX, VCX2, and PNPLA4 presenting with easily controlled focal epilepsy and language delay with mild ichthyosis in a Chinese family with a traceable 4-generation history of skin ichthyosis. Both brain magnetic resonance imaging results were normal, while EEG revealed epileptic abnormalities. We further performed an exhaustive literature search, documenting 25 patients with epilepsy with gene defects in Xp22.31, and summarized the epilepsy heterogeneities between sexes. Males harboring the Xp22.31 deletion mainly manifested with child-onset, easily controlled focal epilepsy accompanied by X-linked ichthyosis; the deletions were mostly X-linked recessive, with copy number variants (CNVs) in the classic region of deletion (863.38 kb–2 Mb). In contrast, epilepsy in females tended to be earlier-onset, and relatively refractory, with pathogenic CNV sizes varying over a larger range (859 kb–56.36 Mb); the alterations were infrequently inherited and almost combined with additional CNVs. A candidate region encompassing STS, HDHD1, and MIR4767 was the likely pathogenic epilepsy-associated region. This study filled in the knowledge gap regarding the genomic and clinical delineations of X-linked recessive epilepsy in the Chinese population and extends the understanding of the sex-specific characteristics of Xp22.31 deletion in regard to epilepsy.
Immunogenic cell death after combined treatment with radiation and ATR inhibitors is dually regulated by apoptotic caspases
Authors: Eek Mariampillai Adrian , Hauge Sissel , Kongsrud Karoline , Syljuåsen Randi G. 
Published: June 2023

IntroductionInhibitors of the ATR kinase act as radiosensitizers through abrogating the G2 checkpoint and reducing DNA repair. Recent studies suggest that ATR inhibitors can also increase radiation-induced antitumor immunity, but the underlying immunomodulating mechanisms remain poorly understood. Moreover, it is poorly known how such immune effects relate to different death pathways such as caspase-dependent apoptosis. Here we address whether ATR inhibition in combination with irradiation may increase the presentation of hallmark factors of immunogenic cell death (ICD), and to what extent caspase activation regulates this response.MethodsHuman lung cancer and osteosarcoma cell lines (SW900, H1975, H460, U2OS) were treated with X-rays and ATR inhibitors (VE822; AZD6738) in the absence and presence of a pan-caspase inhibitor. The ICD hallmarks HMGB1 release, ATP secretion and calreticulin surface-presentation were assessed by immunoblotting of growth medium, the CellTiter-Glo assay and an optimized live-cell flow cytometry assay, respectively. To obtain accurate measurement of small differences in the calreticulin signal by flow cytometry, we included normalization to a barcoded control sample.ResultsExtracellular release of HMGB1 was increased in all the cell lines at 72 hours after the combined treatment with radiation and ATR inhibitors, relative to mock treatment or cells treated with radiation alone. The HMGB1 release correlated largely – but not strictly – with loss of plasma membrane integrity, and was suppressed by addition of the caspase inhibitor. However, one cell line showed HMGB1 release despite caspase inhibition, and in this cell line caspase inhibition induced pMLKL, a marker for necroptosis. ATP secretion occurred already at 48 hours after the co-treatment and did clearly not correlate with loss of plasma membrane integrity. Addition of pan-caspase inhibition further increased the ATP secretion. Surface-presentation of calreticulin was increased at 24-72 hours after irradiation, but not further increased by either ATR or caspase inhibition.ConclusionThese results show that ATR inhibition can increase the presentation of two out of three ICD hallmark factors from irradiated human cancer cells. Moreover, caspase activation distinctly affects each of the hallmark factors, and therefore likely plays a dual role in tumor immunogenicity by promoting both immunostimulatory and -suppressive effects.
Assessing phenotypic virulence of Salmonella enterica across serovars and sources
Authors: Petrin Sara , Wijnands Lucas , Benincà Elisa , Mughini-Gras Lapo , Delfgou-van Asch Ellen H. M. , Villa Laura , Orsini Massimiliano , Losasso Carmen , Olsen John E. , Barco Lisa 
Published: June 2023

IntroductionWhole genome sequencing (WGS) is increasingly used for characterizing foodborne pathogens and it has become a standard typing technique for surveillance and research purposes. WGS data can help assessing microbial risks and defining risk mitigating strategies for foodborne pathogens, including Salmonella enterica.MethodsTo test the hypothesis that (combinations of) different genes can predict the probability of infection [P(inf)] given exposure to a certain pathogen strain, we determined P(inf) based on invasion potential of 87 S. enterica strains belonging to 15 serovars isolated from animals, foodstuffs and human patients, in an in vitro gastrointestinal tract (GIT) model system. These genomes were sequenced with WGS and screened for genes potentially involved in virulence. A random forest (RF) model was applied to assess whether P(inf) of a strain could be predicted based on the presence/absence of those genes. Moreover, the association between P(inf) and biofilm formation in different experimental conditions was assessed.Results and DiscussionP(inf) values ranged from 6.7E-05 to 5.2E-01, showing variability both among and within serovars. P(inf) values also varied between isolation sources, but no unambiguous pattern was observed in the tested serovars. Interestingly, serovars causing the highest number of human infections did not show better ability to invade cells in the GIT model system, with strains belonging to other serovars displaying even higher infectivity. The RF model did not identify any virulence factor as significant P(inf) predictors. Significant associations of P(inf) with biofilm formation were found in all the different conditions for a limited number of serovars, indicating that the two phenotypes are governed by different mechanisms and that the ability to form biofilm does not correlate with the ability to invade epithelial cells. Other omics techniques therefore seem more promising as alternatives to identify genes associated with P(inf), and different hypotheses, such as gene expression rather than presence/absence, could be tested to explain phenotypic virulence [P(inf)].