bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the effects of chronic low-dose radiation exposure in the liver of a hypothermic zebrafish model
Authors: Cahill Thomas , da Silveira Willian Abraham , Renaud Ludivine , Wang Hao , Williamson Tucker , Chung Dongjun , Chan Sherine , Overton Ian , Hardiman Gary 
Published: January 2023

AbstractMankind’s quest for a manned mission to Mars is placing increased emphasis on the development of innovative radio-protective countermeasures for long-term space travel. Hibernation confers radio-protective effects in hibernating animals, and this has led to the investigation of synthetic torpor to mitigate the deleterious effects of chronic low-dose-rate radiation exposure. Here we describe an induced torpor model we developed using the zebrafish. We explored the effects of radiation exposure on this model with a focus on the liver. Transcriptomic and behavioural analyses were performed. Radiation exposure resulted in transcriptomic perturbations in lipid metabolism and absorption, wound healing, immune response, and fibrogenic pathways. Induced torpor reduced metabolism and increased pro-survival, anti-apoptotic, and DNA repair pathways. Coupled with radiation exposure, induced torpor led to a stress response but also revealed maintenance of DNA repair mechanisms, pro-survival and anti-apoptotic signals. To further characterise our model of induced torpor, the zebrafish model was compared with hepatic transcriptomic data from hibernating grizzly bears (Ursus arctos horribilis) and active controls revealing conserved responses in gene expression associated with anti-apoptotic processes, DNA damage repair, cell survival, proliferation, and antioxidant response. Similarly, the radiation group was compared with space-flown mice revealing shared changes in lipid metabolism.
Association between sarcopenia and clinical outcomes in patients with hepatocellular carcinoma: an updated meta-analysis
Authors: Guo Yusheng , Ren Yanqiao , Zhu Licheng , Yang Lian , Zheng Chuansheng 
Published: January 2023

AbstractAlthough numerous studies have reported the association between sarcopenia and the prognosis of hepatocellular carcinoma (HCC) patients, there is lack of a newer and more comprehensive meta-analysis. Herein, a comprehensive literature search was performed on PubMed, Web of Science, the Cochrane Library, and Embase databases to identify relevant studies published up to February 2022. The outcomes were overall survival (OS), recurrence, progression‐free survival, tumor response, severe postoperative complications, and toxicity of drugs. A total of 57 studies involving 9790 HCC patients were included in the meta-analysis. The pooled prevalence of sarcopenia in HCC patients was 41.7% (95% CI 36.2–47.2%). Results demonstrated that sarcopenia was significantly associated with impaired OS (HR: 1.93, 95% CI 1.73–2.17,P < 0.001), higher risk of tumor recurrence (HR: 1.75, 95% CI 1.56–1.96,P < 0.001), lower objective response rate (OR: 0.37 95% CI 0.17–0.81,P = 0.012), and more drug-related adverse events (OR: 2.23, 95% CI 1.17–4.28,P = 0.015) in HCC patients. The subgroup analyses revealed that the OS of patients at the early stage of tumor was more severely affected by sarcopenia than for patients at other stages. Moreover, the presence of cirrhosis and Child Pugh class B increased the hazard of mortality from sarcopenia. This study has shown that sarcopenia is highly associated with poor prognosis in HCC patients. In addition, cirrhosis and poor liver functional reserve increase the danger of sarcopenia. OS was more impaired in HCC patients with sarcopenia at early stage of tumor than at other tumor stages.
Soil–vegetation moisture capacitor maintains dry season vegetation productivity over India
Authors: Sebastian Dawn E. , Murtugudde Raghu , Ghosh Subimal 
Published: January 2023

AbstractIndia receives more than 70% of its annual rainfall in the summer monsoon from June to September. The rainfall is scanty and scattered for the rest of the year. Combining satellite data and model simulations, we show that the soil-vegetation continuum works as a natural capacitor of water, storing the monsoon pulse and releasing the moisture to the atmosphere through evapotranspiration over approximately 135 days when the moisture supply from precipitation is less than the evapotranspiration losses. The total Gross Primary Productivity of vegetation in India during the capacitor period accounts for almost 35% of the total annual GPP value. It primarily depends on the soil moisture at the beginning of the period, a measure of moisture capacitance of soil, with a correlation of 0.6. Given that India is the second largest contributor to recent global greening, its soil-vegetation water capacitance plays a significant role in the global carbon balance.
Combining multi-objective genetic algorithm and neural network dynamically for the complex optimization problems in physics
Authors: Wang Peilin , Ye Kuangkuang , Hao Xuerui , Wang Jike 
Published: January 2023

AbstractNeural network (NN) has been tentatively combined into multi-objective genetic algorithms (MOGAs) to solve the optimization problems in physics. However, the computationally complex physical evaluations and limited computing resources always cause the unsatisfied size of training set, which further results in the combined algorithms handling strict constraints ineffectively. Here, the dynamically used NN-based MOGA (DNMOGA) is proposed for the first time, which includes dynamically redistributing the number of evaluated individuals to different operators and some other improvements. Radio frequency cavity is designed by this algorithm as an example, in which four objectives and an equality constraint (a sort of strict constraint) are considered simultaneously. Comparing with the baseline algorithms, both the number and competitiveness of the final feasible individuals of DNMOGA are considerably improved. In general, DNMOGA is instructive for dealing with the complex situations of strict constraints and preference in multi-objective optimization problems in physics.
Thermodynamic fluctuation theorems govern human sensorimotor learning
Authors: Hack P. , Lindig-Leon C. , Gottwald S. , Braun D. A. 
Published: January 2023

AbstractThe application of thermodynamic reasoning in the study of learning systems has a long tradition. Recently, new tools relating perfect thermodynamic adaptation to the adaptationprocesshave been developed. These results, known as fluctuation theorems, have been tested experimentally in several physical scenarios and, moreover, they have been shown to be valid under broad mathematical conditions. Hence, although not experimentally challenged yet, they are presumed to apply to learning systems as well. Here we address this challenge by testing the applicability of fluctuation theorems in learning systems, more specifically, in human sensorimotor learning. In particular, we relate adaptive movement trajectories in a changing visuomotor rotation task to fully adapted steady-state behavior of individual participants. We find that human adaptive behavior in our task is generally consistent with fluctuation theorem predictions and discuss the merits and limitations of the approach.
Seroprevalence of polyomaviruses BK and JC in Finnish women and their spouses followed-up for three years
Authors: Laine Hanna K. , Waterboer Tim , Syrjänen Kari , Grenman Seija , Louvanto Karolina , Syrjänen Stina 
Published: January 2023

AbstractBK (BKPyV) and JC (JCPyV) polyomavirus infections are commonly subclinical and known infrequently to cause serious clinical diseases. Longitudinal follow-up studies regarding JCPyV and BKPyV serological outcomes are scanty. We analyzed JCPyV and BKPyV IgG-antibodies in 327 pregnant women and their 132 spouses, enrolled in the longitudinal Finnish Family HPV cohort at Turku University Hospital, Finland. Blood samples taken at baseline, and at 12-, 24-, and 36-month follow-up visits were analyzed for capsid protein VP1-antibodies using multiplex serology. Seroprevalence was constant for both BKPyV and JCPyV across the follow-up, varying between 95–99% and 59–68%, respectively, in women and between 96–97% and 66–72%, respectively, in their spouses. Seroconversion to BKPyV and JCPyV was detected in 15% and 18% of the women and in 13% and 19% of the men, respectively. Waning of BKPyV and JCPyV antibodies was infrequent, present in only 5% of the women (both viruses) and in 1.5% of the male spouses (only BKPyV). The number of lifetime sexual partners (p = 0.038) was lower among JCPyV seropositive men. To conclude, seropositivity to BKPyV and JCPyV is common among marital couples in Finland, with only slight differences between genders. In men, the sexual behavior might be associated with JCPyV seroprevalence.
A method for measuring meaningful physiological variables in fish blood without surgical cannulation
Authors: Davison William George. , Cooper Christopher A. , Sloman Katherine A. , Wilson Rod W. 
Published: January 2023

AbstractGaining meaningful blood samples from water-breathing fish is a significant challenge. Two main methods typically used are grab ‘n’ stab and surgical cannulation. Both methods have benefits, but also significant limitations under various scenarios. Here we present a method of blood sampling laboratory fish involving gradual induction of anaesthesia within their home tank, avoiding physical struggling associated with capture, followed by rapid transfer to a gill irrigation system to maintain artificial ventilation via adequate gill water flow and then followed by sampling the caudal vasculature. This method negates many blood chemistry disturbances associated with grab ‘n’ stab (i.e., low pH and oxygen, elevated lactate, CO2 and stress hormones) and generates results that are directly comparable to cannulated fish under a wide range of experimentally-induced acid–base scenarios (acidosis and alkalosis). Crucially this method was successful in achieving accurate acid–base blood measurements from fish ten times smaller than are typically suitable for cannulation. This opens opportunities not previously possible for studies that relate to basic physiology, sustainable aquaculture, ecotoxicology, conservation, and climate change.
Dopaminergic and cholinergic modulation of the amygdala is altered in female mice with oestrogen receptor β deprivation
Authors: Kalinowski Daniel , Bogus-Nowakowska Krystyna , Kozłowska Anna , Równiak Maciej 
Published: January 2023

AbstractThe amygdala is modulated by dopaminergic and cholinergic neurotransmission, and this modulation is altered in mood disorders. Therefore, this study was designed to evaluate the presence/absence of quantitative alterations in the expression of main dopaminergic and cholinergic markers in the amygdala of mice with oestrogen receptor β (ERβ) knock-out which exhibit increased anxiety, using immunohistochemistry and quantitative methods. Such alterations could either contribute to increased anxiety or be a compensatory mechanism for reducing anxiety. The results show that among dopaminergic markers, the expression of tyrosine hydroxylase (TH), dopamine transporter (DAT) and dopamine D2-like receptor (DA2) is significantly elevated in the amygdala of mice with ERβ deprivation when compared to matched controls, whereas the content of dopamine D1-like receptor (DA1) is not altered by ERβ knock-out. In the case of cholinergic markers, muscarinic acetylcholine type 1 receptor (AChRM1) and alpha-7 nicotinic acetylcholine receptor (AChRα7) display overexpression while the content of acetylcholinesterase (AChE) and vesicular acetylcholine transporter (VAChT) remains unchanged. In conclusion, in the amygdala of ERβ knock-out female the dopaminergic and cholinergic signalling is altered, however, to determine the exact role of ERβ in the anxiety-related behaviour further studies are required.
Fabrication and thermoelectric conversion of thermoelectric concrete brick with buried unileg N-type CaMnO3 thermoelectric module inside
Authors: Maneesai Keerati , Khammahong Sunisar , Siripoom Pongsakorn , Phrompet Chaiwat , Sriwong Chaval , Maensiri Santi , Ruttanapun Chesta 
Published: January 2023

AbstractTo investigate the effect of heat loss reduction due to thermal insulator and thermal interface resistance due to multi-layer structure in order to improve the efficiency of a thermoelectric device, a thermoelectric concrete brick was fabricated using a unileg n-type CaMnO3 thermoelectric module inside. CaMnO3 thermoelectric materials were synthesized by starting materials CaCO3 and MnO2 to produce a unileg n-type CaMnO3 module. Thermoelectric concrete brick consisted of two types: I-layer brick (one layer of concrete thermal insulator) and III-layer brick (three layers of different concrete insulators). The occurring temperature difference, electric current and voltage on the CaMnO3 module and thermoelectric concrete brick were measured in closed and open circuits. The temperature difference, thermal distribution, and output voltage when applying constant temperatures of 100, 200 and 400 °C were measured. Computer simulations of the Finite Element Method (FEM) were performed to compare with the experimental results. The trends of the temperature difference and the output voltage from the experimental and computer simulations were in good agreement. The results of the temperature difference during the hotter side temperature of 200 °C exhibited the temperature difference along the vertical direction of the thermoelectric concrete bricks for both types of the III-layer brick of 172 °C and the I-layer brick of 132 °C are larger than that of the CaMnO3 TEG module without using a thermal concrete insulator of 108 °C. The thermoelectric concrete bricks of the III-layer brick type of 27.70 mV displayed output voltage results being higher than those of the I-layer brick of 26.57 mV and the CaMnO3 TEG module without using a thermal concrete insulator of 24.35 mV. Thermoelectric concrete brick of the III-layer brick type displayed higher electric generation power than the I-layer brick and the CaMnO3 TEG module. Additionally, the results exhibited the capability of thermoelectric concrete brick in the III-layer brick model for electric generation power based on the temperature difference. The TEG concrete brick of I-layer concrete covering the series–parallel combination circuit of 120 modules of the unileg n-type CaMnO3 was constructed and then embedded on the outer surface of the furnace. During the maximum hotter side temperature of 580 °C of the concrete brick, the temperature difference between the hotter side and the cooler side of the brick occurred at 365 °C and the maximum output voltage was obtained at 581.7 mV.
Effects of emission trading scheme (ETS) on change rate of carbon emission
Authors: Jung Hail , Song Chang-Keun 
Published: January 2023

AbstractThis paper investigates the effects of Emission Trading Scheme (ETS) adoption on the country-level reduction rate of carbon emission. We first used Environmental Kuznets Curve (EKC) tests to group countries into three categories: inverse U-shaped and gamma-shaped EKC for decoupled countries, and a positive linear EKC for non-decoupled countries. We then examined the effectiveness of ETS adoption. We found ETS was effective for both post-industrial and pre-industrial economies. Compared to countries that have not adopted ETS, the carbon emission reduction (increment) rate of decoupled (non-decoupled) countries that have adopted ETS is faster (slower). Furthermore, ETS adoption significantly reduces overall carbon emissions per capita compared to other global events, such as oil crises. The results imply that a market-based mechanism is an effective strategy for achieving sustainable development, thus, providing insights for policymakers and governments to design effective carbon neutrality policies to achieve sustainable development.
Optically driven microtools with an antibody‐immobilised surface for on‐site cell assembly
Authors: Mori Shuntaro , Ito Takumi , Takao Hidekuni , Shimokawa Fusao , Terao Kyohei 
Published: January 2023

AbstractTo enable the accurate reproduction of organs in vitro, and improve drug screening efficiency and regenerative medicine research, it is necessary to assemble cells with single‐cell resolution to form cell clusters. However, a method to assemble such forms has not been developed. In this study, a platform for on‐site cell assembly at the single‐cell level using optically driven microtools in a microfluidic device is developed. The microtool was fabricated by SU‐8 photolithography, and antibodies were immobilised on its surface. The cells were captured by the microtool through the bindings between the antibodies on the microtool and the antigens on the cell membrane. Transmembrane proteins, CD51/61 and CD44 that facilitate cell adhesion, commonly found on the surface of cancer cells were targeted. The microtool containing antibodies for CD51/61 and CD44 proteins was manipulated using optical tweezers to capture HeLa cells placed on a microfluidic device. A comparison of the adhesion rates of different surface treatments showed the superiority of the antibody‐immobilised microtool. The assembly of multiple cells into a cluster by repeating the cell capture process is further demonstrated. The geometry and surface function of the microtool can be modified according to the cell assembly requirements. The platform can be used in regenerative medicine and drug screening to produce cell clusters that closely resemble tissues and organs in vivo.
VPNEP: Detailed characterization of TESS targets around the Northern Ecliptic Pole
Authors: Strassmeier K. G. , Weber M. , Gruner D. , Ilyin I. , Steffen M. , Baratella M. , Järvinen S. , Granzer T. , Barnes S. A. , Carroll T. A. , Mallonn M. , Sablowski D. , Gabor P. , Brown D. , Corbally C. , Franz M. 
Published: January 2023

Context.We embarked on a high-resolution optical spectroscopic survey of bright Transiting Exoplanet Survey Satellite (TESS) stars around the Northern Ecliptic Pole (NEP), dubbed the Vatican-Potsdam-NEP (VPNEP) survey.Aims.Our NEP coverage comprises ≈770 square degrees with 1067 stars, of which 352 are bona fide dwarf stars and 715 are giant stars, all cooler than spectral type F0 and brighter thanV= 8m.5. Our aim is to characterize these stars for the benefit of future studies in the community.Methods.We analyzed the spectra via comparisons with synthetic spectra. Particular line profiles were analyzed by means of eigenprofiles, equivalent widths, and relative emission-line fluxes (when applicable).Results.TwoR= 200 000 spectra were obtained for each of the dwarf stars with the Vatican Advanced Technology Telescope (VATT) and the Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI), with typically threeR= 55 000 spectra obtained for the giant stars with STELLA and the STELLA Echelle Spectrograph (SES). Combined withV-band magnitudes,GaiaEDR3 parallaxes, and isochrones from the Padova and Trieste Stellar Evolutionary Code, the spectra can be used to obtain radial velocities, effective temperatures, gravities, rotational and turbulence broadenings, stellar masses and ages, and abundances for 27 chemical elements, as well as isotope ratios for lithium and carbon, line bisector spans, convective blue-shifts (when feasible), and levels of magnetic activity from Hα, Hβ, and the Ca IIinfrared triplet. In this initial paper, we discuss our analysis tools and biases, presenting our first results from a pilot sub-sample of 54 stars (27 bona-fide dwarf stars observed with VATT+PEPSI and 27 bona-fide giant stars observed with STELLA+SES) and making all reduced spectra available to the community. We carried out a follow-up error analysis, including systematic biases and standard deviations based on a joint target sample for both facilities, as well as a comparison with external data sources.
Mobilization of science advice by the Canadian federal government to support the COVID-19 pandemic response
Authors: Bhatia Dominika , Allin Sara , Di Ruggiero Erica 
Published: January 2023

AbstractThe procurement and provision of expert-driven, evidence-informed, and independent science advice is integral to timely decision-making during public health emergencies. The 2019 coronavirus disease (COVID-19) pandemic has underscored the need for sound evidence in public health policy and exposed the challenges facing government science advisory mechanisms. This paper is a jurisdictional case study describing (i) the federal science advice bodies and mechanisms for public health in Canada (i.e., the federal science advice “ecosystem”); and (ii) how these bodies and mechanisms have mobilized and evolved to procure expertise and evidence to inform decisions during the first two years of the COVID-19 pandemic. We reviewed publicly accessible Government of Canada documents, technical reports, and peer-reviewed articles available up to December 2021. Canada’s federal landscape of science advisory bodies for public health within the Health Portfolio was largely shaped by Canada’s experiences with the 2003 severe acute respiratory syndrome and 2009 H1N1 outbreaks. In parallel, Canada has a designated science advisory apparatus that has seen frequent reforms since the early 2000s, with the current Office of the Chief Science Advisor created within the Science Portfolio in 2018. The COVID-19 pandemic has further complicated Canada’s science advice ecosystem, with involvement from departments, expert advisory groups, and partnerships within both the federal Health and Science Portfolios. Although the engagement of federal departments outside the health sector is promising, the COVID-19 experience in Canada supports the need to institutionalize science advisory bodies for public health to improve pandemic preparedness and ensure rapid mobilization of well-coordinated and independent advice in future emergencies. This review also identified pressing areas for further inquiry to strengthen science advice for public health in Canada, including to assess the independence of science advisory actors and the interaction between federal and subnational authorities.
Pick-up strategies for and electrical characterization of ZnO nanowires with a SEM-based nanomanipulator
Authors: Liu Mei , Kong Lingdi , Su Weilin , Djoulde Aristide , Cheng Kai , Chen Jinbo , Rao Jinjun , Wang Zhiming 
Published: January 2023

Because of their unique mechanical and electrical properties, zinc oxide (ZnO) nanowires are used widely in microscopic and nanoscopic devices and structures, but characterizing them remains challenging. In this paper, two pick-up strategies are proposed for characterizing the electrical properties of ZnO nanowires using SEM equipped with a nanomanipulator. To pick up nanowires efficiently, direct sampling is compared with electrification fusing, and experiments show that direct sampling is more stable while electrification fusing is more efficient. ZnO nanowires have cut-off properties, and good Schottky contact with the tungsten probes was established. In piezoelectric experiments, the maximum piezoelectric voltage generated by an individual ZnO nanowire was 0.07 V, and its impedance decreased with increasing input signal frequency until it became stable. This work offers a technical reference for the pick-up and construction of nanomaterials and nanogeneration technology.