bluuebunny/crossref_metadata_2025_split huggingface dataset:
Folate receptor overexpression shortensC. eleganslifespan by impeding adaptation to microbial metabolism
Authors: Shrestha Bideep , Tallila Milla , Matilainen Olli 
Published: June 2023

AbstractFolate receptor (FR) alpha and beta (FRα and FRβ) are membrane-anchored transporters that mediate folate uptake through endocytosis. Unlike other folate transporters, FRs are expressed at low levels in normal tissues, while their expression is strongly increased in several cancers. In addition to its canonical role in folate transport, FRα, the most studied FR, also regulates signaling pathways unrelated to folate- or one-carbon metabolism. Nevertheless, it is not known how loss of folate receptors, or their overexpression, affects health- and lifespan. To elucidate this, we utilizedCaenorhabditis elegans, in which FOLR-1 is the sole homolog of folate receptors. Interestingly, loss of FOLR-1 does not affect reproduction, fitness, proteostasis or lifespan, indicating that it is not required for folate transport to maintain health. Strikingly, in contrast tofolr-1depletion,folr-1overexpression shortens lifespan in a coculturedE. colistrain-dependent manner. Furthermore, we found thatfolr-1overexpression blunts the lifespan extension upon treatment with sulfamethoxazole, a sulfonamide that promotes longevity by limiting folate inE. coli. These data suggest that animals overexpressingfolr-1are deficient in their ability to adapt to changes in microbial metabolism, thus revealing an intriguing and non-canonical role of FR in lifespan regulation. Therefore, this work could serve as a basis for further studies to elucidate the organismal effects of abnormal FR expression in diseases such as cancer.Author SummaryFolate receptors (FRs) differ from other folate transporters based on, for example, these two things: their expression is strongly restricted, and they can regulate intracellular cellular processes independently of folate- and one-carbon metabolism (OCM). Interestingly, FRs have an essential role in embryonic development, but on the other hand, their overexpression in cancer have been shown to reduce patient survival. Apart from development and disease, the role of FRs in aging remains unknown. By utilizingC. elegans, we show that FOLR-1 (FR homolog inC. elegans) is not required to maintain normal physiology, whereas its overexpression shortens lifespan through a mechanism dependent on cocultured bacteria. Since cocultured bacteria constitute theC. elegansgut microbiota, this study places elevated FR expression as a link between gut commensal bacteria and organism’s lifespan, raising the intriguing question of whether the same mechanism applies in cancer.
The role of micropyle for grass pea germination
Authors: Wiraguna Edi 
Published: June 2023

PurposeThis study aims to identify the location of the micropyle, the role of the micropyle in seed germination and the association between the micropyle size and seed weight of grass peas.Design/methodology/approachFirst, the micropyle was identified by cutting the seed in half and observing the seeds under the electron microscope. Second, the micropyle was covered by lanolin to block water imbibition. The rate of imbibition and germination was then observed. Lastly, micropyle sizes of various grass pea genotypes were identified by capturing seed images under a light microscope and converting the sizes to mm2 using computer software (ImageJ).FindingsThe location of micropyle was located nearby the hilum, similar to soybean seeds. Seed imbibition was significantly lower in lanolin application (<87%) than in the control (>124%) after 24 hours of submergence. Germination was a day delay for lanolin application on the micropyle compared to lanolin application on the non-micropyle. The germination delay resulted in a significantly lower germination percentage at <57% on the micropyle lanolin application than at >79% on the non-micropyle lanolin application after 10 days of sowing. There is no correlation between the micropyle size and seed weight.Originality/valueThese findings add information on the location and the role of the micropyle for grass pea seed germination.
The impact of board gender diversity on financial performance: a systematic review and agenda for future research
Authors: Hazaea Saddam A. , Al-Matari Ebrahim Mohammed , Farhan Najib H.S. , Zhu Jinyu 
Published: June 2023

Purpose
In recent years, mandatory rules and regulations were issued to stress the importance of increasing gender diversity in companies, assuming that gender diversity would enhance financial performance. Thus, the purpose of this paper is to review recent research concerning board gender diversity and its impact on financial performance for the period of 2002 to 2022.

Design/methodology/approach
Using the Web of Science and Scopus databases, 152 studies were analyzed, out of 91 high-impact journals. The analysis focuses on discussing the moderating, mediating and controlling variables and exploring the theories and theoretical foundations that are most prevalent in the literature.

Findings
The findings indicated an incompatibility between the results of the studies on the impact of gender diversity on financial performance. In addition, results showed the majority of studies focused on discussing the controlling variables associated with the company compared to the variables related to employees or the surrounding environment. On the other hand, the results also showed widespread use of the theoretical basis with the development of new theories in the recent period in parallel with the increase in the literature.

Originality/value
The results of this study help to reconcile the findings of the different and conflicting literature by presenting the perception that the efficacy of the positive impact of gender diversity on financial performance is related to several organizational and environmental factors that companies have to consider.
Reviving the experiential store: the effect of scarcity and perceived novelty in driving word-of-mouth
Authors: Pape Denise , Toporowski Waldemar 
Published: June 2023

PurposeExperiential stores offer potential for emotional brand-consumer connections and word-of-mouth (WoM) generation. Past research links the lifecycle of such stores with perceived novelty, a defining characteristic that has not received sufficient recognition. Scarce products are identified as a promising strategy to enhance novelty perceptions. Additionally, the authors differentiate between electronic and interpersonal WoM, and consider need for uniqueness (NFU) as a relevant personality variable.Design/methodology/approachThis study encompasses three experiments that seek to shed light on suggested relationships. The first two experiments explore the interplay between scarcity, perceived novelty, and WoM. Moving forward, the third study delves deeper into the matter, scrutinizing the conditions under which scarce products manifest their utility in experiential stores.FindingsThe findings indicate that incorporating scarce products can rejuvenate the novelty aspect of experiential stores and promote positive WoM outcomes. Additionally, including NFU as a personality variable presents a communication dilemma, as high NFU individuals tend to engage more in electronic WoM but less in interpersonal WoM. However, this relationship is contingent on circumstances, with high NFU individuals showing a greater inclination towards interpersonal WoM when the probability of being imitated is low.Practical implicationsThis study offers practical guidance for brand managers aiming to sustain the appeal and success of their experiential stores, as well as for commercial real estate managers seeking to revitalize vacant spaces in the post-COVID-19 era.Originality/valueThis pioneering study investigates the role of perceived novelty and scarce products in experiential stores, aiming to identify optimal conditions for favorable consumer responses. It also contributes to research on the forward spillover effect and underscores the importance of interpersonal proximity in WoM investigations.
Symbolic power, discourse, and underrepresentation of women in IT
Authors: Jurado Tanya , Tretiakov Alexei , Bensemann Jo 
Published: June 2023

PurposeThe authors aim to contribute to the understanding of the enduring underrepresentation of women in the IT industry by analysing media discourse triggered by a campaign intended to encourage women to join the IT industry.Design/methodology/approachInternet media coverage of the Little Miss Geek campaign in the UK was analysed as qualitative data to reveal systematic and coherent patterns contributing to the social construction of the role of women with respect to the IT industry and IT employment.FindingsWhile ostensibly supporting women's empowerment, the discourse framed women's participation in the IT industry as difficult to achieve, focused on women's presumed “feminine” essential features (thus, effectively implying that they are less suitable for IT employment than men), and tasked women with overcoming the barrier via individual efforts (thus, implicitly blaming them for the imbalance). In these ways, the discourse worked against the broader aims of the campaign.Social implicationsCampaigns and organisations that promote women's participation should work to establish new frames, rather than allowing the discourse to be shaped by the established frames.Originality/valueThe authors interpret the framing in the discourse using Bourdieu's perspective on symbolic power: the symbolic power behind the existing patriarchal order expressed itself via framing, thus contributing to the maintenance of that order. By demonstrating the relevance of Bourdieu's symbolic power, the authors offer a novel understanding of how underrepresentation of women in the IT sector is produced and maintained.
Cross-country determinants of citizens' e-government reuse intention: empirical evidence from Kuwait and Poland
Authors: Mirkovski Kristijan , Rouibah Kamel , Lowry Paul , Paliszkiewicz Joanna , Ganc Marzena 
Published: June 2023

PurposeDespite the major information technology investments made by public institutions, the reuse of e-government services remains an issue as citizens hesitate to use e-government websites regularly. The purpose of this study is to investigate the cross-country determinants of e-government reuse intention by proposing a theoretical model that integrates constructs from (1) the Delone and McLean IS success model (i.e. system quality, service quality, information quality, perceived value and user satisfaction); (2) the trust and risk models (i.e. citizen trust, overall risk, time risk, privacy risk and psychological risks); and (3) Hofstede's cultural model (i.e. uncertainty avoidance, masculinity, individualism and cross-cultural trust and risk).Design/methodology/approachBased on data from interviews with 81 Kuwaiti citizens and surveys of 1,829 Kuwaiti and Polish citizens, this study conducted comprehensive, cross-cultural and comparative analyses of e-government reuse intention in a cross-country setting.FindingsThe results show that trust is positively associated with citizens' intention to reuse e-government services, whereas risk is negatively associated with citizens' perceived value. This study also found that masculinity–femininity and uncertainty avoidance are positively associated with the intention to reuse e-government services and that individualism–collectivism has no significant relationship with reuse intention. This study's findings have important implications for researchers and practitioners seeking to understand and improve e-government success in cross-country settings.Originality/valueThis study developed a parsimonious model of quality, trust, risk, culture and technology reuse that captures country-specific cultural contexts and enables us to conduct a comprehensive, cross-cultural and comparative analysis of e-government reuse intention in the cross-country setting of Kuwait and Poland.
From big data epistemology to AI politics: rescuing the public dimension over data-driven technologies
Authors: Calzati Stefano 
Published: June 2023

PurposeThe purpose of this paper is to explore the epistemological tensions embedded within big data and data-driven technologies to advance a socio-political reconsideration of the public dimension in the assessment of their implementation.Design/methodology/approachThis paper builds upon (and revisits) the European Union’s (EU) normative understanding of artificial intelligence (AI) and data-driven technologies, blending reflections rooted in philosophy of technology with issues of democratic participation in tech-related matters.FindingsThis paper proposes the conceptual design of sectorial and/or local-level e-participation platforms to ignite an ongoing discussion – involving experts, private actors, as well as cognizant citizens – over the implementation of data-driven technologies, to avoid siloed, tech-solutionist decisions.Originality/valueThis paper inscribes the EU’s normative approach to AI and data-driven technologies, as well as critical work on the governance of these technologies, into a broader political dimension, suggesting a way to democratically and epistocratically opening up the decisional processes over the development and implementation of these technologies and turn such processes into a systemic civic involvement.
Assessing the validity of race and ethnicity coding in administrative Medicare data for reporting outcomes among Medicare advantage beneficiaries from 2015 to 2017
Authors: Huang Andrew W. , Meyers David J. 
Published: June 2023

AbstractObjectiveTo assess the validity of race/ethnicity coding in Medicare data and whether misclassification errors lead to biased outcome reporting by race/ethnicity among Medicare Advantage beneficiaries.Data Sources and Study SettingIn this national study of Medicare Advantage beneficiaries, we analyzed individual‐level data from the Health Outcomes Survey (HOS) and the Consumer Assessment of Healthcare Providers and Systems (CAHPS), race/ethnicity codes from the Medicare Master Beneficiary Summary File (MBSF), and outcomes from the Medicare Provider Analysis and Review (MedPAR) files from 2015 to 2017.Study DesignWe used self‐reported beneficiary race/ethnicity to validate the Medicare Enrollment Database (EDB) and Research Triangle Institute (RTI) race/ethnicity codes. We measured the sensitivity, specificity, and positive and negative predictive values of the Medicare EDB and RTI codes compared to self‐report. For outcomes, we compared annualized hospital admission, 30‐day, and 90‐day readmission rates.Data Collection/Extraction MethodsData for Medicare Advantage beneficiaries who completed either the HOS or CAHPS survey were linked to MBSF and MedPAR files. Validity was assessed for both self‐reported multiracial and single‐race beneficiaries.Principal FindingsFor beneficiaries enrolled in Medicare Advantage, the EDB and RTI race/ethnicity codes have high validity for identifying non‐Hispanic White or Black beneficiaries, but lower sensitivity for beneficiaries self‐reported Hispanic any race (EDB: 28.3%, RTI: 85.9%) or non‐Hispanic Asian American or Native Hawaiian Pacific Islander (EDB: 56.1%, RTI: 72.1%). Only 8.7% of beneficiaries self‐reported non‐Hispanic American Indian Alaska Native are correctly identified by either Medicare code, resulting in underreported annualized hospitalization rates (EDB: 31.5%, RTI: 31.6% vs. self‐report: 34.6%). We find variation in 30‐day readmission rates for Hispanic beneficiaries across race categories, which is not measured by Medicare race/ethnicity coding.ConclusionsCurrent Medicare race/ethnicity codes misclassify and bias outcomes for non‐Hispanic AIAN beneficiaries, who are more likely to select multiple racial identities. Revisions to race/ethnicity categories are needed to better represent multiracial/ethnic identities among Medicare Advantage beneficiaries.
Comparison of first‐pass intubation success rates between two different videolaryngoscopes in an Australian prehospital and retrieval medicine service
Authors: Lacquiere David , Mazur Stefan , Wilkes Anthony , Pearce Andrew 
Published: June 2023

AbstractObjectiveTo determine the effectiveness of the GlideScope Go videolaryngoscope (VL) in tracheal intubation in an Australian physician‐staffed critical care prehospital and retrieval medicine service.MethodsOur service has used VLs for several years, including the McGrath Mac, and from February 2019 the GlideScope Go. Clinicians may alternatively use direct laryngoscopy with a Macintosh laryngoscope. We conducted a non‐inferiority trial comparing first‐pass intubation success using the GlideScope Go VL with that using the McGrath Mac VL. We collected data on video intubation of all adult patients between February 2017 and December 2019, by our service. Comparison was also made with patients intubated using direct laryngoscopy with a Macintosh direct laryngoscope.ResultsOne hundred and seventy‐two patients were intubated with the aid of a VL. First‐pass success rates (95% confidence interval [CI]) were 0.98 (0.92–0.99) and 0.92 (0.84–0.96), respectively, for the GlideScope Go and McGrath Mac, giving a difference (95% CI) in first‐pass success rates of 0.06 (−0.01 to 0.13). First‐pass success rate for the Macintosh laryngoscope was 0.88 (0.84–0.91).ConclusionsWe demonstrated that first‐pass success rates with the GlideScope Go are at least as good as our service had achieved with both the McGrath Mac and with direct laryngoscopy.
Comparing the results from a Swedish pregnancy cohort using data from three automated placental growth factor immunoassay platforms intended for first‐trimester preeclampsia prediction
Authors: Carlsson Ylva , Sandström Anna , Bergman Lina , Conner Peter , Hansson Stefan , Kublickas Marius , Görmüş Uzay , Lindgren Peter , Oleröd Göran , Wikström Anna‐Karin , Larsson Anders 
Published: June 2023

AbstractIntroductionRisk evaluation for preeclampsia in early pregnancy allows identification of women at high risk. Prediction models for preeclampsia often include circulating concentrations of placental growth factor (PlGF); however, the models are usually limited to a specific PlGF method of analysis. The aim of this study was to compare three different PlGF methods of analysis in a Swedish cohort to assess their convergent validity and appropriateness for use in preeclampsia risk prediction models in the first trimester of pregnancy.Material and methodsFirst‐trimester blood samples were collected in gestational week 11+0 to 13+6 from 150 pregnant women at Uppsala University Hospital during November 2018 until November 2020. These samples were analyzed using the different PlGF methods from Perkin Elmer, Roche Diagnostics, and Thermo Fisher Scientific.ResultsThere were strong correlations between the PlGF results obtained with the three methods, but the slopes of the correlations clearly differed from 1.0: PlGFPerkinElmer = 0.553 (95% confidence interval [CI] 0.518–0.588) * PlGFRoche –1.112 (95% CI −2.773 to 0.550); r = 0.966, mean difference −24.6 (95% CI −26.4 to −22.8). PlGFPerkinElmer = 0.673 (95% CI 0.618–0.729) * PlGFThermoFisher –0.199 (95% CI −2.292 to 1.894); r = 0.945, mean difference −13.8 (95% CI −15.1 to −12.6). PlGFRoche = 1.809 (95% CI 1.694–1.923) * PlGFPerkinElmer +2.010 (95% CI −0.877 to 4.897); r = 0.966, mean difference 24.6 (95% CI 22.8–26.4). PlGFRoche = 1.237 (95% CI 1.113–1.361) * PlGFThermoFisher +0.840 (95% CI −3.684 to 5.363); r = 0.937, mean difference 10.8 (95% CI 9.4–12.1). PlGFThermoFisher = 1.485 (95% CI 1.363–1.607) * PlGFPerkinElmer +0.296 (95% CI −2.784 to 3.375); r = 0.945, mean difference 13.8 (95% CI 12.6–15.1). PlGFThermoFisher = 0.808 (95% CI 0.726–0.891) * PlGFRoche –0.679 (95% CI −4.456 to 3.099); r = 0.937, mean difference −10.8 (95% CI −12.1 to −9.4).ConclusionThe three PlGF methods have different calibrations. This is most likely due to the lack of an internationally accepted reference material for PlGF. Despite different calibrations, the Deming regression analysis indicated good agreement between the three methods, which suggests that results from one method may be converted to the others and hence used in first‐trimester prediction models for preeclampsia.
What if my boss is a narcissist? The effects of chief executive officer narcissism on female proportion in top management teams
Authors: Martínez‐Ferrero Jennifer , García‐Meca Emma , Ramón‐Llorens M. Camino 
Published: June 2023

AbstractFor the period 2015–2019 and based on a Spanish sample of 145 listed companies, this paper provides insights into how narcissistic chief executive officers (CEOs) influence the proportion of women in top management teams (TMTs). As a further analysis and in line with social psychology and upper echelons theories, we study whether the power and gender of a CEO and the female proportion in the firm's board moderate the relationship. Our results reveal that narcissistic CEOs are less likely to support women in TMTs, confirming that CEO personality traits influence team structure. Further results suggest that this aversion increases as the CEO's power grows and is a woman, and when female proportion in board decreases. The results have an impact on the gender equality goal, demonstrating that the behavior of women toward promoting gender equality in TMTs depends both on the specific position of women in the firm's hierarchy and on their personal psychological attributes. We find that women directors support social identity values and that narcissistic female CEOs act like queen bees.
A sequential cohort study evaluating single‐agent KappaMab and KappaMab combined with lenalidomide and low‐dose dexamethasone in relapsed and/or refractory kappa light chain‐restricted multiple myeloma (AMaRC 01‐16)
Authors: Spencer Andrew , Kalff Anna , Shortt Jake , Quach Hang , Wallington‐Gates Craig , Reynolds John , Walker Patricia , Harrison Simon J. , Dunn Rosanne , Wellard Cameron 
Published: June 2023

SummaryKappaMab (KM; formerly MDX‐1097) is a monoclonal antibody specific for the kappa myeloma antigen (KMA), a cell‐surface antigen expressed on malignant plasma cells in kappa‐restricted multiple myeloma (κMM), some lymphomas, occasional tonsillar B cells and in vitro activated B cells, but not on normal B cells in bone marrow. Phase I/IIa studies of single‐agent KM confirmed a favourable toxicity profile and evidence of anti‐myeloma activity. Ex‐vivo studies demonstrating upregulation of KMA by lenalidomide, and enhanced effector‐cell cytotoxicity provided the rationale for this phase IIb study where KM or KM in combination with lenalidomide and dexamethasone (KM‐Rd) was administered in relapsed, refractory κMM patients. In addition, outcomes for a real‐world matched case–control cohort from the Australian and New Zealand Myeloma and Related Diseases Registry (MRDR) who received Rd were compared to the KM‐Rd cohort. KM‐Rd demonstrated an overall response rate of 82.5% which compared favourably to the Rd‐MRDR cohort of 45.1%. Both single‐agent KM and KM‐Rd regimens were well tolerated, with the KM‐Rd safety profile similar to patients given only Rd in other clinical settings. Based on the excellent safety profile and significant efficacy, further clinical trials escalating the KM dose and pairing KM with other standard‐of‐care treatments are planned.