bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic internalization by cutting versus removal of the endoscopic transpapillary naso‐gallbladder drainage tube in preoperative management of acute cholecystitis: A retrospective multicenter cohort study
Authors: Maruta Akinori , Iwashita Takuji , Yoshida Kensaku , Iwata Keisuke , Shimizu Shogo , Shimizu Masahito 
Published: June 2023

AbstractBackgroundEndoscopic transpapillary naso‐gallbladder drainage (ENGBD) has been reported to be an effective treatment option for acute cholecystitis. At our institution, ENGBD was first placed for external fistula management, and endoscopic internalization by cutting was performed, shifting to endoscopic transpapillary gallbladder stenting (EGBS) after improvement of cholecystitis. However, there has been no comparative study to define which preoperative management is better: converting ENGBD to EGBS or removing ENGBD.The study aimed to compare the incidence rate of the late adverse events (AEs) related to biliary system between shifting from ENGBD to EGBS and removal of ENGBD.MethodsWe retrospectively studied 122 patients who underwent ENGBD for acute cholecystitis between January 2010 and October 2022. The patients were divided into two groups: the cutting group (converting ENGBD to EGBS) and the removal group (removal of ENGBD). The short and late clinical outcomes were compared between groups.ResultsEndoscopic transpapillary naso‐gallbladder drainage was successfully placed in 78.6% (96/122), and elective cholecystectomy was performed in 31 and 36 patients in the cutting and removal groups, respectively. The cumulative late‐AE rates were 6.4% and 33.3% (p = .007), with a median waiting period for elective cholecystectomy of 58 and 33 days (p = .390) in the cutting and removal groups, respectively. In the multivariate analysis, only endoscopic internalization by cutting was an independent factor affecting late AEs.ConclusionEndoscopic internalization by cutting ENGBD after the resolution of acute cholecystitis was considered effective in reducing the risk of late AEs during the waiting period for an elective cholecystectomy.
Synthesis of bioactive quinoline appended spiro pyrrolidines as antioxidants
Authors: Ali M. Mohamed Arshath , Suriyan G. Udhaya , Surya K. Jaga , Mani Kailasam Saravana 
Published: June 2023

AbstractA multicomponent reaction eliminates operational challenges and boosts the atom economy of the reaction process. A vast class of compounds known as pyrrolidine‐derived heterocycles act as crucial scaffolding for anticancer drugs. The scientists are inspired to create several pyrrolizine derivatives and test their potential antitumor activity against a wide range of cancer types by Mitomycin C's unique anticancer capabilities. We developed an efficient and highly discriminating three‐component reaction between isatin/indenoquinoxaline, l‐phenyl alanine, and quinolinyl‐derived chalcones in methanol results in the synthesis of biologically active novel spiro pyrrolidines that contain three pharmacophoric cores, heterocyclic quinoline scaffold, pyrrolidines, and oxindoles in a single‐molecular framework viz 1,3‐dipolar cycloaddition reaction. FT‐IR, NMR, and mass spectroscopic methods were used to elucidate the structures of the synthesized compounds. With butyrated hydroxy toluene serving as a positive control, the synthesized compounds were tested for antioxidant properties utilizing nitric oxide, 1,1‐diphenylpicrylhydrazide, and super oxide radicals, and the results were analyzed.
Change from low to out‐of‐season epidemics of influenza in China during the COVID‐19 pandemic: A time series study
Authors: Cao Guiying , Guo Zirui , Liu Jue , Liu Min 
Published: June 2023

AbstractNonpharmaceutical interventions to limit the coronavirus disease 2019 (COVID‐19) pandemic might reduce the transmission of influenza viruses and disrupt the typical seasonality of influenza. However, changes in epidemiology and seasonal patterns of influenza remain unknown in China during the COVID‐19 pandemic. Data on influenza‐like illness (ILI) and influenza cases between surveillance Week 14 in 2010 and Week 6 in 2023 and ILI outbreaks between Week 14 in 2013 and Week 6 in 2023 were collected from the weekly reports of the Chinese National Influenza Center. A total of 32 10 735 ILI specimens were tested between Week 14 in 2010 and Week 6 in 2023 in China, with 12.4% of specimens positive for influenza. The influenza‐positive percentage ranged from 11.8% to 21.1% in southern China and 9.5% to 19.5% in northern China between the 2010/2011 and 2019/2020 influenza seasons. The influenza‐positive percentage was 0.7% in southern China and 0.2% in northern China in the 2020/2021 season. An increasing trend in influenza‐positive percentage was observed in southern China in Weeks 18–27 in the 2022/2023 season, with a peak of 37.3%. A total of 768 ILI outbreaks reported in southern China in Weeks 14–26 in the 2022/2023 season were much more than those in the same period in the 2020/2021 and 2021/2022 seasons. In summary, seasonal influenza shifted from low to out‐of‐season epidemics during the COVID‐19 pandemic in China, especially in southern China. Influenza vaccination and everyday preventive actions, such as mask wearing, appropriate air exchange, and good hand hygiene practices, are essential for the prevention of influenza virus infection during the COVID‐19 pandemic.
Global and regional estimates of cervical cancer burden associated with human immunodeficiency virus infection from 1990 to 2019
Authors: Wan Zhengwei , Zhao Jianhui , Xu Liying , Sun Ping , Shuai Ping , Li Kangning , Zhang Yixuan , Chen Yan , Su Qian , Yao Xiaoqin , Li Xue , Liu Yuping 
Published: June 2023

AbstractPrevious studies reported human immunodeficiency virus (HIV) could enhance human papillomavirus (HPV)‐induced cervical cancer. Therefore, the burden of cervical cancer associated with HIV across different regions and time periods need to be assessed. We aim to investigate the global burden of cervical cancer associated with HIV infection. Age standardized rates (ASRs) of cervical cancer disability‐adjusted life‐years (DALYs) in females (≥15 years old) were calculated by standardization, according the age‐specific DALYs numbers extracted from GBD data set 2019. Population attributable fractions was calculated by combining the published risk ratio, with the HIV prevalence (≥15 years old) from Joint United Nations Programme on HIV and AIDS (UNAIDS), and transferred to estimate the HIV‐associated cervical cancer burden. Expected annual percentage changes (EAPCs) was calculated to describe the temporal trend of ASR from 1990 to 2019. Pearson correlation analysis were conducted to assess the correlation between the ASR or EAPCs and the socio‐demographic index. The worldwide DALYs ASR caused by HIV‐associated cervical cancer rose from 3.78 (95% confidence interval [CI]: 2.19–5.56) in 1990 to 9.50 (95% CI: 5.66–13.79) in 2019 per 100k population. In 2019, the region with the greatest burden was Eastern and Southern Africa, with the highest DALYs of 273 900 (95% CI: 149 100–476 400) and ASR of 254.44 per 100k population (95% CI: 168.86–329.28). Notably, the Eastern Europe and Central Asia regions had the highest EAPC (14.07%) of HIV‐associated DALYs ASR. Women in Eastern and Southern Africa experience the greatest burden of HIV‐associated cervical cancer, while the Eastern Europe and Central Asia regions had witnessed the largest increase over the last 30 years. Prioritize the promotion of HPV vaccination and cervical cancer screening for women living with HIV were crucial in these regions.
Performance evaluation of CMIP6 HighResMIP models in simulating precipitation over Madagascar
Authors: Randriatsara Herijaona Hani‐Roge Hundilida , Hu Zhenghua , Xu Xiyan , Ayugi Brian , Sian Kenny Thiam Choy Lim Kam , Mumo Richard , Ongoma Victor , Holtanova Eva 
Published: June 2023

AbstractThe present study evaluates the performance of high‐resolution global climate models derived from Coupled Model Intercomparison Project Phase 6 (CMIP6 HighResMIP), in simulating rainfall characteristics over Madagascar on an annual and seasonal scales for the period 1981–2014. The models and their ensemble mean are assessed based on two observational datasets sourced from Climate Hazards Group Infrared Precipitation with Station data version 2 (CHIRPS v2.0) data and the European Centre for Medium‐Range Weather Forecasts (ECMWF) reanalysis fifth generation‐Land dataset (ERA5) as the references throughout the diverse analyses. A Taylor diagram, accompanied by the Taylor skill score (TSS), is used for the annual and seasonal model‐rankings and the overall performance of the models. The best‐performing models are EC‐Earth3P‐HR, ECMWF‐IFS‐HR, ECMWF‐IFS‐LR and HadGEM3‐GC31‐MM. The least‐recommended models with remarkable biases are BCC‐CSM2‐HR, CAMS‐CSM1‐0, FGOALS‐f3‐H, MPI‐ESM1‐2‐HR and MPI‐ESM1‐2‐XR. It is worth mentioning that FGOALS‐f3‐H tends to overestimate rainfall in most analyses, while MPI‐ESM1‐2‐HR and MPI‐ESM1‐2‐XR underestimate it. The findings of this study are of great importance to climatologists and present an opportunity for further investigation of underlying processes responsible for the observed wet/dry biases in order to improve the forecast skills in the models over the study area.
Tibial bone strength is negatively affected by volumetric muscle loss injury to the adjacent muscle in male mice
Authors: Schifino Albino G. , Cooley Marion A. , Zhong Roger X. , Heo Junwon , Hoffman Daniel B. , Warren Gordon L. , Greising Sarah M. , Call Jarrod A. 
Published: June 2023

AbstractThis study's objective was to investigate how contractile strength loss associated with a volumetric muscle loss (VML) injury affects the adjacent tibial bone structural and functional properties in male C57BL/6J mice. Mice were randomized into one of two experimental groups: VML‐injured mice that were injured at age 12 weeks and aged to 20 weeks (8 weeks postinjury, VML) and 20‐week‐old age‐matched uninjured mice (Uninjured‐20). Tibial bone strength, mid‐diaphysis cortical geometry, intrinsic material properties, and metaphyseal trabecular bone structure were assessed by three‐point bending and microcomputed tomography (µCT). The plantar flexor muscle group (gastrocnemius, soleus, plantaris) was analyzed for its functional capacities, that is, peak‐isometric torque and peak‐isokinetic power. VML‐injured limbs had 25% less peak‐isometric torque and 31% less peak‐isokinetic power compared to those of Uninjured‐20 mice (p < 0.001). Ultimate load, but not stiffness, was significantly less (10%) in tibias of VML‐injured limbs compared to those from Uninjured‐20 (p = 0.014). µCT analyses showed cortical bone thickness was 6% less in tibias of VML‐injured limbs compared to Uninjured‐20 (p = 0.001). Importantly, tibial bone cross‐section moment of inertia, the primary determinant of bone ultimate load, was 16% smaller in bones of VML‐injured limbs compared to bones from Uninjured‐20 (p = 0.046). Metaphyseal trabecular bone structure was also altered up to 23% in tibias of VML‐injured limbs (p < 0.010). These changes in tibial bone structure and function after a VML injury occur during a natural maturation phase between the age of 12 and 20 weeks, as evidenced by Uninjured‐20 mice having greater tibial bone size and strength compared to uninjured‐aged 12‐week mice.
Attributional negativity bias and acute stress disorder symptoms mediate the association between trauma history and future posttraumatic stress disorder
Authors: Webb E. Kate , Timmer‐Murillo Sydney C. , Huggins Ashley A. , Tomas Carissa W. , deRoon‐Cassini Terri A. , Larson Christine L. 
Published: June 2023

AbstractIndividuals who have experienced more trauma throughout their life have a heightened risk of developing posttraumatic stress disorder (PTSD) following injury. Although trauma history cannot be retroactively modified, identifying the mechanism(s) by which preinjury life events influence future PTSD symptoms may help clinicians mitigate the detrimental effects of past adversity. The current study proposed attributional negativity bias, the tendency to perceive stimuli/events as negative, as a potential intermediary in PTSD development. We hypothesized an association between trauma history and PTSD symptom severity following a new index trauma via heightened negativity bias and acute stress disorder (ASD) symptoms. Recent trauma survivors (N =189, 55.5% women, 58.7% African American/Black) completed assessments of ASD, negativity bias, and lifetime trauma 2‐weeks postinjury; PTSD symptoms were assessed 6 months later. A parallel mediation model was tested with bootstrapping (10,000 resamples). Both negativity bias, Path b1: β = −.24, t(187) = −2.88, p = .004, and ASD symptoms, Path b2: β = .30, t(187) = 3.71, p < .001, fully mediated the association between trauma history and 6‐month PTSD symptoms, full model: F(6, 182) = 10.95, p < .001, R 2= .27; Path c’: β = .04, t(187) = 0.54, p = .587. These results suggest that negativity bias may reflect an individual cognitive difference that can be further activated by acute trauma. Moreover, negativity bias may be an important, modifiable treatment target, and interventions addressing both acute symptoms and negativity bias in the early posttrauma period may weaken the link between trauma history and new‐onset PTSD.
Persistence of the association between mental health and resource access: A longitudinal reciprocal model in a diverse refugee sample
Authors: Blackwell Meredith A. , Lardier David , Choe Ryeora , Goodkind Jessica R. 
Published: June 2023

AbstractStress associated with resource deprivation is an active social determinant of mental health. However, mixed findings around the strength of this association and its persistence over time obscure optimal interventions to improve mental health in forcibly displaced populations. A reciprocal model was analyzed between resource access and measures of depression, anxiety and posttraumatic stress (PTSD) symptoms at three different assessments conducted 6 months apart (Time [T] 1, T2, and T3). Participants included resettled refugees (N = 290) from three geocultural regions (i.e., Afghanistan, the Great Lakes Region of Africa, and Iraq/Syria). The results showed that although limited resource access at T1 was related to depressive and anxiety symptoms, B = 0.26, SE = 0.16, p = .023, r2 = 0.55; posttraumatic stress disorder (PTSD) symptoms, B = 0.20, SE = 0.10, p < .001, r2 = .56; and culturally specific depression and anxiety at T2, B = 0.22, SE = 0.16, p < .001, r2 = 0.65, these were not reciprocally related to resource access at T3. The results help clarify the strength and direction of effects between resource deprivation and depression, anxiety , and PTSD sympotms over time. Although resource deprivation is predictive of depression, anxiety, and PTSD symptoms among recently resettled refugees, the effect may not persist in the long term. These findings have critical implications, including the urgency of ensuring initial access to resources for resettled refugees to stave off the development of depression, anxiety and PTSD symptoms, as delaying immediate resource access may result in the development of chronic, hard‐to‐treat mental health disorders.
Skin involvement in systemic lymphoma of follicular helper T‐cell origin: A cohort study of 57 patients
Authors: Stammler Romain , Battistella Maxime , Calvani Julien , Louveau Baptiste , Lemonnier François , Ingen‐Housz Oro Saskia , Ortonne Nicolas , Bouaziz Jean David , Rivet Jacqueline , Vignon‐Pennamen Marie‐Dominique , Boutboul David , Ram‐Wolff Caroline , Galicier Lionel , Thieblemont Catherine , Brice Pauline , Renaud Loïc , Jeudy Geraldine , Beylot‐Barry Marie , Le Clech Christian , Nardin Charlée , Cayuela Jean‐Michel , Meignin Véronique , Mourah Samia , Bagot Martine , De Masson Adèle ,   French Study Group on Cutaneous Lymphomas
Published: June 2023

AbstractBackgroundAngioimmunoblastic T‐cell lymphoma (AITL) is one of the most frequent peripheral T‐cell lymphomas (PTCL) in western countries. Skin involvement is common and may reveal the malignancy. Despite its frequency, skin involvement in AITL has been poorly described.ObjectivesWe aimed to analyze the cutaneous expression of PTCL of TFH origin and its prognostic impact.MethodsWe conducted a multicenter retrospective cohort study by retrieving histopathological reports including the mention ‘AITL’ or ‘PTCL with T‐follicular helper phenotype’ (PTCL‐TFH) from five French tertiary hospital centers.ResultsFrom 2000 to 2022, we reviewed 382 histopathological records and identified 52 AITL cases and 5 PTCL‐TFH cases with cutaneous involvement. Thirty‐two (56%) patients were males with a mean age of 63 years. Fifty‐six (98%) patients presented with lymphadenopathy, 32 (56%) splenomegaly and 17 (30%) hepatomegaly. B signs were present in 34 (60%) patients. Skin lesions were present on the lower limbs in 44 (77%) patients, trunk in 38 (67%) patients, upper limbs in 35 (61%) and head in 27 (47%). Macules and papules were the most frequent lesions found in 47 (82%) patients, followed by nodules in 10 (17%) patients, erythemato‐squamous plaques in 10 (17%) patients, purpura in 9 (16%), urticaria in 9 (16%) and blisters in 5 (9%) patients. Erythroderma affected seven patients (12%). A skin biopsy was taken in 50 patients and revealed a specific lymphomatous infiltrate in 36 cases. A dominant skin T‐cell clone was detected in 13 out of 17 (76%) patients. Among the 14 patients with a nonspecific dermatitis, various histopathological patterns were observed including interface dermatitis, psoriasiform dermatitis, vasculitis, bullous dermatitis, granulomatous dermatitis and thrombotic vasculopathy. After a median follow‐up of 24 months (range, 0–121 months), median overall survival was 121 months (95% CI, 25.2–NA). At last follow‐up, 33 patients (58%) were alive, 20 (35%) were in complete remission and 7 (12%) were in partial remission; 30 (53%) patients experienced at least one relapse, including nodal relapses in 24 (80%) cases and cutaneous relapses in 12 (40%).ConclusionsThis study revealed the deep heterogeneity of skin presentations in AITL. Atypical skin presentations were common and included blistering, purpuric and psoriasiform eruptions.
Suppression of cAMP/PKA/CREB signaling ameliorates retinal injury in diabetic retinopathy
Authors: Fang Xiao‐Ling , Zhang Qin , Xue Wen‐Wen , Tao Jin‐Hua , Zou Hai‐Dong , Lin Qiu‐Rong , Wang Yu‐Lan 
Published: June 2023

AbstractThe blood‐retinal barrier (BRB), homeostasis, neuronal integrity, and metabolic processes are all directly influenced by Müller cells, the most important retinal glial cells. We isolated primary Müller cells from Sprague–Dawley (SD) neonatal rats and treated them with glucose at varying doses. CCK‐8 was used to quantify cellular viability, and a TUNEL assay was performed to detect cell apoptosis. ELISA, immunofluorescence, and western blotting were used to assess cAMP/PKA/CREB signaling, Kir4.1, AQP4, GFAP, and VEGF levels, respectively. H&E staining was used to examine histopathological alterations in diabetic retinopathy (DR)‐affected retinal tissue in rats. As glucose concentration increases, gliosis of Müller cells became apparent, as evidenced by a decline in cell activity, an increase in apoptosis, downregulation of Kir4.1 level, and overexpression of GFAP, AQP4, and VEGF. Treatments with low, intermediate, and high glucose levels led to aberrant activation of cAMP/PKA/CREB signaling. Interestingly, blocking cAMP and PKA reduced high glucose‐induced Müller cell damage and gliosis by a significant amount. Further in vivo results suggested that cAMP or PKA inhibition significantly improved edema, bleeding, and retinal disorders. Our findings showed that high glucose exacerbated Müller cell damage and gliosis via a mechanism involving cAMP/PKA/CREB signaling.
Trends of potentially illegal deforestation over protected areas of Rio das Velhas basin, Brazil
Authors: de Oliveira Amanda Ribeiro , Pacheco Fernando António Leal , Fernandes Luís Filipe Sanches , da Costa Adriana Monteiro 
Published: June 2023

AbstractDespite the promise to increase control and fight against deforestation, the new Brazilian Forest Code (BFC) allowed more flexible dimensioning and land use rules in areas of private rural properties intended for native vegetation protection, namely the Legal Reserve (LR) and Areas of Permanent Preservation (APP). Following a decade of BFC implementation, the promise was somewhat flawed, while oversight and monitoring of private rural properties were not as expected. Considering this worrying scenario, the objective of this study was to quantify and map the forest balance of private rural properties listed in the Environmental Rural Registry of Rio das Velhas hydrographic basin (Minas Gerais, 2002), to assess compliance with the BCF and detect potentially illegal deforestation. The total deforested area in 6216 (28.7%) registered private rural properties reached approximately 119,800 ha after 2008, 61,500 ha of which were suppressed without surplus forest of LR. Besides, nearly half of the private rural properties presented forest deficits in the APPs. In a vast majority of cases, the deforestation was potentially illegal, but only a small number of private rural property owners was made responsible for that. The deforested areas were concentrated in small sectors within the rural properties, which would facilitate the control of illegal native vegetation suppression if oversight and law enforcement had been effective. Our results are an alert and a subside to public institutions and rural property owners while developing and executing plans, programs, and projects focused on environmental regularization of rural properties, with the ultimate goal of preventing further land degradation in the basin.
Primary versus salvage intratympanic steroid treatment for idiopathic sudden sensorineural hearing loss
Authors: Lan Wei‐Che , Lin Chia‐Der , Tsou Yung‐An , Shih Liang‐Chun , Aoh Yu , Lu Chien‐Chi , Hsu Hsiu‐San , Lai Chun‐Yu , Wang Ching‐Yuan 
Published: June 2023

AbstractObjectiveThe objective of this research is to compare primary and salvage intratympanic (IT) steroid treatments in terms of hearing outcomes in patients with idiopathic sudden sensorineural hearing loss (ISSNHL).MethodsThe patients were randomized into two (primary and salvage) groups. Both groups received systemic steroid treatment for 2 weeks. The primary group also received IT dexamethasone injection three times during the treatment period, whereas the salvage group received IT dexamethasone injection only if no or slight recovery was noted at the 2‐week follow‐up. If needed, salvage steroid injection was administered three times during the following 2 weeks. Hearing recovery was analyzed according to the modified American Academy of Otolaryngology‐Head and Neck Surgery criteria.ResultsThe degrees of hearing improvement at the 3‐month follow‐up were similar in the two groups. Compared with baseline, the pure‐tone average values and speech discrimination scores improved by 38.45 ± 21.95 dB HL and 34.32% ± 30.55%, respectively, in the primary group and 36.80 ± 22.33 dB HL and 31.87% ± 27.88%, respectively, in the salvage group (p = .762 and .659, respectively). In addition, the complete or partial hearing recovery rates were also similar in the primary and salvage groups (67.7% vs. 73.3%, respectively; p = .780). In the salvage group, 18 patients required no IT steroid injection because they recovered after systemic steroid treatment.ConclusionPrimary and salvage IT steroid treatments for ISSNHL led to similar outcomes. In summary, salvage IT steroid injection is recommended for patients with ISSNHL patients to prevent unnecessary IT injection.Level of evidence2.