bluuebunny/crossref_metadata_2025_split huggingface dataset:
A potential alternative systemic treatment option for epithelioid sarcoma
Authors: Xie Lu , Xu Jie , Liang Xin , Liu Kuisheng , Sun Xin , Sun Kunkun , Yang Rongli , Tang Xiaodong , Guo Wei 
Published: December 2022

Abstract
Background: Epithelioid sarcoma is a rare soft tissue sarcoma characterized by SMARCB1/INI1 deficiency. Much attention has been paid to the selective EZH2 inhibitor tazemetostat, where other systemic treatments are generally ignored. To explore alternative treatment options, we studied the effects of irinotecan-based chemotherapy in a series of epithelioid sarcoma patients.
Methods: We retrospectively reviewed data from patients with metastatic or unresectable epithelioid sarcoma at the Peking University People’s Hospital treated with irinotecan (50 mg/m2/d d1-5 Q3W) in combination with Anlotinib (12 mg Qd, 2 weeks on and 1 week off) from July 2015 to November 2021.
Results: A total of 54 courses were administered. With a median follow up of 21.2 months (95% CI, 12.2, 68.1), the 5-year overall survival rate was 83.3%. Five of eight (62.5%) patients presented with unresectable localized lesions, including local tumor thrombosis and lymphatic metastasis. The other patients had unresectable pulmonary metastases. Six of eight (75%) patients had progressed following two lines of systemic therapy. The objective response rate reached 37.5% (three of eight patients) while stabilized disease was observed in 62.5% (five of eight) of patients. No patient had progressed at initial evaluation. At the last follow up, two patients were still using the combination and three patients had ceased the therapy due to toxicities such as diarrhea, nausea, and emesis. One patient changed to tazemetostat for maintenance and one patient stopped treatment due to coronavirus disease 2019 (COVID-19). Another patient stopped therapy as residual lesions had been radiated.
Conclusions: The combination of irinotecan and Anlotinib as a salvage regimen may be considered another effective treatment option for refractory epithelioid sarcoma.
Trial registration: This trial was approved in the Medical Ethics Committee of Peking University People’s Hospital on October 28, 2022 (No.: 2022PHD015-002). The trial was registered in Clinicaltrials.gov with identifier no. NCT05656222.
Complexity Review of NIMBY conflict: Characteristics, Mechanism and Evolution Simulation
Authors: Luxin Cui , Yu Chen , Xing Wang , ShiYu Liu 
Published: December 2022

Abstract
Complexity is an essential characteristic of NIMBY systems, and few studies have analyzed NIMBY conflicts using the theory of complex adaptive systems. From the perspective of complexity, this study re-examines the characteristics and evolution mechanism of NIMBY conflicts and draws the following conclusions: (1) NIMBY conflicts are a complex system of interaction between multiple subjects and the environment, characterized by aggregation, Linearity, dynamics, flow characteristics, and hierarchy. (2) Build a stimulus-response model for the evolution mechanism of NIMBY conflicts based on the theory of complex adaptive systems and consider that adaptability is the driving force for the evolution of NIMBY conflicts. The effector promotes NIMBY subjects to gradually adapt to changes in the external environment and maximize their interests. (3) Using Agent simulation technology to simulate the evolution mechanism of NIMBY conflicts, we found that how the government responds to conflicts is more important than the intervention time; Residents' communication efficiency and connection probability will affect residents' behavior choices； The lower the residents' communication efficiency, the less likely it is to form NIMBY conflicts， and stronger resident relations can accelerate residents' convergence to the exit state, affecting the evolution of NIMBY conflicts. This study deepens the understanding of NIMBY conflicts and provides a new reference perspective for the governance of NIMBY conflicts.
In vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer
Authors: Martinez Sebastian , Geuenich Michael , Malik Ahmad , Weber Ramona , Woo Tristan , Jang Gun-Ho , Derovic Dzana , Al-Zahrani Khalid , Tsai Ricky , Fodil Nassima , Gros Philippe , Gallinger Steven , Neely G. , Notta Fayiaz , Sendoel Ataman , Campbell Kieran , Schramek Daniel 
Published: December 2022

Abstract

Functionally characterizing the genetic alterations that drive pancreatic cancer is a prerequisite for precision medicine. Here, we performed somatic CRISPR/Cas9 mutagenesis screens to assess the transforming potential of 125 recurrently mutated pancreatic cancer genes, which revealed USP15 and SCAF1 as novel pancreatic tumor suppressors. Mechanistically, we found that USP15 functions in a haplo-insufficient manner and that loss of USP15 or SCAF1 leads to reduced inflammatory TNFα, TGF-β and IL6 responses and increased sensitivity to PARP inhibition and Gemcitabine. Furthermore, we found that loss of SCAF1 led to the formation of a truncated, inactive USP15 isoform at the expense of full-length USP15, functionally coupling SCAF1 and USP15. Notably, USP15 and SCAF1 alterations are observed in 31% of pancreatic cancer patients. Our results highlight the utility of in vivo CRISPR screens to integrate human cancer genomics and mouse modeling for the discovery of novel cancer driver genes with potential prognostic and therapeutic implications.
Dissolution of a commercial regenerated cellulosic fibre (Cordenka) in the ionic liquid 1-ethyl-3-methylimidazolium acetate studied using time-temperature superposition
Authors: Alanazi Maer , Ries Michael E. , Hine Peter J. 
Published: December 2022

Abstract
Wide-angle X-ray diffraction (WAXS) and mechanical testing techniques are used to track the dissolution of a regenerated commercial cellulose fibre (Cordenka) in the ionic liquid 1-ethyl-3-methyl-imidazolium acetate [C2mim]+ [OAc]− for different times and temperatures. In the dissolution process, the oriented cellulose II crystals in the regenerated cellulose fibres dissolve and then reform into randomly oriented crystals to form a matrix phase, and this change in orientation enables us to follow the dissolution process using WAXS, and hence determine the dissolved matrix volume fraction vm. The change in the average molecular orientation P2 determined from an azimuthal (α) X-ray scan, allows the growth of the matrix volume fraction vm to be calculated with time and temperature. The growth of vm was found to follow time temperature superposition, with an Arrhenius behaviour, giving a value for the activation energy of Ea= 149 ± 4 kJ/mol. Young’s modulus was measured on all the resulting composite fibres. The fall of Young’s modulus with dissolution time and temperature was also found to follow time-temperature superposition, with an Arrhenius behaviour giving a value for Ea= 198 ± 29 kJ/mol. The Young’s Modulus results plotted against vm determined from the WAXS measurements fitted well to the Voigt upper bound parallel Rule of Mixtures.
Missed Nursing Care And Associated Factors Among Nurses At University Of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2022. A cross sectional study
Authors: Kassie Huluager , Endalkachew Kidist , Kassahun Chanyalew Worku 
Published: December 2022

Abstract
Introduction: The lack of nursing care is the most common cause of quality problems in health care that results in adverse outcomes for patients, nurses, and organizations. Although there is a lot of evidence regarding nursing care practices, there is limited evidence about missed nursing care and its factors in Ethiopia and no evidence at all in the study area. Therefore, this study was designed to assess missed nursing care and related factors among nurses.
Methods: An institutional-based cross-sectional study was conducted among 485 nurses at the University of Gondar Comprehensive Specialized Hospital from May 15 to June 15, 2022. The data were collected through a self-reported questionnaire. A simple random sampling technique was used to select study participants. The data was then added to EPI DATA version 4.6 and exported to SPSS version 23 for analysis. Descriptive statistics were computed, and a summative score of missed nursing care was calculated. Then, multiple linear regression analysis was used to identify the factors of missed nursing care. A P-value of 0.05 was used to identify significant factors.
Results: In this study, missed nursing care was 62.5% (95% CI 60.98-64.02). Documentation of all necessary data, assessment of vital signs, intravenous care, and assessment as per hospital policy and patient education were the most frequently lacking nursing care. Being single in marital status (B=-4.609, P =0.004), adequacy of nursing staff (B=-2.458, P=0.003), satisfaction with income (B=-8.753, P=0.007), working in the medical unit (B=-5.708, P=0.002) and working in both day and night shift (B=1.731, P=0.027) were statistically associated with missed nursing care.
Conclusion recommendation: In this study, more than half of the participants missed basic nursing care. Efforts should be considered to enhance communication between health team members, assign a manageable number of patients per nurse, and adjust shifts and units.
Assessment of Ant's Biodiversity in human land use habitats using the SDR software
Authors: Farajollahzade Sepideh , Ramezani Leila , Mohammadi Shima 
Published: December 2022

Abstract

Ants are a major part of the ecosystem as they assist in the decomposition process and improve soil quality. They are a great component of animal biomass and act as ecosystem engineers. We assessed the species richness and biodiversity of these arthropods in the habitats with varying degrees of human impact in Shiraz, Fars Province, southern Iran. To this end, 6 habitats (a farm, a dry land and a natural garden in the countryside, and three old gardens (Be’sat, Janat, Babakoohi) in the city) were chosen and sampled bimonthly during 2015–2106. A total of 6270 ant workers belonging to 30 species, 12 genera, and 3 subfamilies were recorded. The most specious subfamily was Formiciniae (16 Specious) followed by Myrmicinae (12 Species), and Dolichoderinae (2 Species). All biodiversity indices (Shannon wiener, Simpson and Margalof) showed a greater diversity in both natural garden and urban landscape: Be’sat and Janat garden, with the lowest amount of human effects, respectively as well as Babakoohi and the lowest in the agricultural and dry land, which had the most effect of human disturbance. Although a significant difference was observed with the habitats (F, 4.255, P = 0.004) and the months (F, 4.327, P = 0.002) of sampling, there was not a significant difference between Babakoohi, natural garden, Janat and Be’sat gardens ((P > 0.05)) nor between field and dry land (P > 0.05), and those two habitats had fewer species compared with the natural garden and city landscape. The highest Jaccard similarity index (0.773) was seen between Janat garden in the city landscape and Babakoohi and then with both Janat and Be’sat gardens (0.731); however, the lowest (0.48) was seen between dry land and Be’sat garden. The result showed that the species composition in the city landscape including different gardens is more similar than the farm and dry land. The Jaccard similarity index between dry land and farm was 0.58 which indicated the low similarity of the ant species in those regions.
The effectiveness of optimal exercise-based strategy for elderly patients with hip fracture: A systematic review and Bayesian network meta-analysis
Authors: Pan Rong-jia , Gui Si-jie , He Yu-Lian , Nian Fang , Ni Xiao-Yan , Zhou Yan-hui , Wang Man-yi , Wu Jing-jing , Zeng Gu-qing , Liang Jing-hong , Peng Dan 
Published: December 2022

Abstract
Exercise intervention (EI) is a promising and economical way for elderly patients with hip fracture, but it is unclear which type of exercise is optimal. To assess the effectiveness of different EIs and identify the optimal EI of improving the prognosis for elderly patients with hip fracture. We searched Medline (via PubMed), Web of Science, Embase, Cochrane Central Register of Controlled Trials, CINAHL, CNKI, Wan Fang, VIP and CBM from their earliest records to June 2022. The included randomized controlled trials (RCT) included at least one type of exercise for patients with hip fracture. The methodological quality of these trials was assessed using the Cochrane Collaboration Risk of Bias Tool, Stata 14.0 software was used for NMA. The primary outcome was hip function, and the secondary outcomes were activity of daily living (ADL), walking capacity and balance ability of the patients. This study included 46 RCTs involving 3,286 patients. Based on the recovery of patients' hip function, resistance exercise (RE) ([MD]: -11.07, [Crl]: -15.07 to -7.08) showed significant benefits over the control group (CG). RE ([MD]: -8.86, [Crl]: -15.01 to -2.71) ([MD]: -9.09, [Crl]: -14.20 to -3.98) showed significant benefits over the weight-bearing exercise and aerobic exercise. In addition, RE (surface under cumulative ranking curve values [SUCRA]: 94.8%) and balance exercise (BE) ([SUCRA]: 81.1%) were most likely to be the optimal exercise methods for hip function recovery. BE may be the most effective exercise in improving ADL([SUCRA]: 98.4%) and balance ability([SUCRA]: 88.4%). These results suggest that RE and BE might be the best approach to improve prognosis for elderly patients with hip fracture. More well-designed and high-quality RCTs are needed to verify the conclusions drawn from this study.
Groundwater contamination source identification based on Sobol Sequences-based Sparrow Search Algorithm with a BiLSTM surrogate model
Authors: Ge Yuanbo , Lu Wenxi , Pan Zidong 
Published: December 2022

Abstract

In the traditional linked simulation-optimization method, solving the optimization model requires massive invoking of the groundwater numerical simulation model, which causes a huge computational load. In the present study, a surrogate model of the origin simulation model was developed using a Bidirectional Long and Short-term Memory neural network method (BiLSTM). Compared with the surrogate models built by shallow learning methods (BP neural network) and traditional LSTM methods, the surrogate model built by BiLSTM has higher accuracy and better generalization performance while reducing the computational load. The BiLSTM surrogate model was linked to the optimization model and solved using the Sparrow Search Algorithm based on Sobol sequences (SSAS). SSAS enhances the diversity of the initial population of sparrows by introducing Sobol sequences and introduces nonlinear inertia weights to control the search range and search efficiency. Compared with SSA, SSAS has stronger global search ability and faster search efficiency. And SSAS identifies the contamination source location and release intensity stably and reliably. This study also applied the Cholesky decomposition method to establish a Gaussian field for hydraulic conductivity to evaluate the feasibility of the simulation-optimization method.
Secular trend analysis of antibiotic utilisation in some hospitals in western China from 2010 to 2020
Authors: Wu Zhigui , Li Yuan , Li Rong , Sun Xuemei , Chen Tao , Yu Yongqi , Shi Yue , Luo Hongli 
Published: December 2022

Abstract
Objectives
In order to rationalize the clinical application of antibiotics and effectively curb bacterial drug resistance, the Ministry of Health of China launched a special rectification activity for antibiotics in 2011. After more than 10 years of development, whether the policy has achieved results. Therefore, this article aims to study the situation and trend of clinical application of antibiotics in some hospitals in western China to investigate the implementation of this activity.
Design Retrospective study
Methods
This study collected and analyzed antibiotic data from nine hospitals in western China in 2010, 2015, and 2020, including the rate of antibiotic use in outpatients and inpatients, the cost of antibiotic use, the intensity of antibiotic use in inpatients, and antibiotic use during the type Ⅰ incisions of perioperative period.
Results
After 10 years of continuous improvement, the utilization rate of antibiotics in outpatients of these 9 hospitals continued to decline and was controlled below 20% by 2020, while the utilization rate in inpatients also significantly decreased, most of which were controlled within 60%. The use intensity of antibiotics decreased from an average of 79.95 DDD (defined daily doses) per 100 patient-days in 2010 to 37.96 DDD per 100 patient-days in 2020. Although the prophylactic use of antibiotics decreased significantly in type Ⅰ incisions, some hospitals still exceeded 30% and failed to meet the standard. However, the proportion of use within 30 min - 1 h before operation was significantly increased.
Conclusions
After the special rectification and sustained development of the clinical application of antibiotics, the use of antibiotics in some hospitals in western China is basically reasonable, and the relevant indicators tend to be stable, indicating that this activity is conducive to improving the level of rational clinical application of antibiotics.
Sharp bounds for multilinear fractional integral operators on Morrey type spaces: the endpoint cases
Authors: Zheng Suting , Wang Dinghuai , Hu Xi 
Published: December 2022

Abstract
In this paper, the Strichartz’s result of the exponential integrability of fractional integral operators is improved. Also, we establish the endpoint boundedness of the multilinear fractional integrals acting on the multi-Morrey spaces. The conclusions relax the restriction that pi ≠ 1 for all i = 1, · · · , m and extend some known results.
2020 Mathematical Subject Classification. 42B20, 42B35.
Circular RNA circTRRAP promotes malignant phenotypes of colorectal cancer by sponging miR-194-3p
Authors: Yu De-Ming , Wang Zhen-Jun , Chen Hong-Yu , Chen Zhi-Lei , Yang Lei , Li Xiang-Nan 
Published: December 2022

Abstract
To explore the mechanism of circTRRAP (hsa_circ_0081311) in regulating the progression of colorectal cancer (CRC). Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to detect the expression of circTRRAP. Receiver operating characteristic (ROC) curve for circTRRAP was produced. In vitro and in vivo experiments of circTRRAP were conducted. Target miRNAs of circTRRAP were analyzed bymiRanda software. Analyses based on The Cancer Genome Atlas (TCGA) database were conducted to screen the target miRNAs. Luciferase reporter assay was conducted to analyze the interaction between circTRRAP and hsa-miR-194-3p (miR-194-3p). In vitro reverse experiments were conducted to analyze the effect of circTRRAP/miR-194-3p axis on CRC.The results suggested that circTRRAP was up-regulated in CRC patients’ tissues and plasma, and associated with unfavorable clinicopathologic features. The area under curve (AUC) of 0.741 suggested that circTRRAP could serve as a potential biomarker for CRC. CircTRRAP promoted the malignant phenotypes of CRC in vitro and in vivo. CircTRRAP could bind to miR-194-3p, which was significantly down-regulated in CRC tissues and associated with overall survival according to TCGA database. CircTRRAP had no effect on the expression level of miR-194-3p, and miR-194-3p up-regulation had the similar tumor-suppressing effects as circTRRAP down-regulation. The tumor-promoting effect of circTRRAP up-regulation could be reversed by the up-regulation of miR-194-3p. Conclusively, circTRRAP was up-regulated in CRC, and associated with unfavorable clinicopathologic features. CircTRRAP could serve as a promising biomarker for CRC diagnosis. CircTRRAP promoted the progression of CRC by sponging miR-194-3p and could serve as a potential therapeutic target for CRC treatment.
Tuberculosis infection prevention and control in rural Papua New Guinea: An evaluation using the Infection Prevention and Control Assessment Framework
Authors: Marme Gigil , Kuzma Jerzy , Zimmerman Peta-Anne , Harris Neil , Rutherford Shannon 
Published: December 2022

Abstract

Background: Papua New Guinea (PNG) is one of the 14 countries categorized as having a triple burden of tuberculosis (TB), multidrug-resistant TB (MDR TB), and TB-human immunodeficiency virus (HIV) co-infections. TB infection prevention and control (TB-IPC) guidelines were introduced in 2011 by the National Health Department of PNG. This study assesses the implementation of this policy in a sample of district hospitals in two regions of PNG.
Methods: The implementation of TB-IPC policy was assessed using a survey method based on the World Health Organization (WHO) IPC assessment framework (IPCAF) to implement the WHO’s IPC core components. The study included facility assessment at ten district hospitals and validation observations of TB-IPC practices.
Results: Overall, implementation of IPC and TB-IPC guidelines was inadequate in participating facilities. Though 80% of facilities had an IPC program, many needed more clearly defined IPC objectives, budget allocation, and yearly work plans. In addition, they did not include senior facility managers in the IPC committee. Eighty percent (n=8 of 10) of hospitals had no IPC training and education; 90% had no IPC committee to support the IPC team; 70% had no surveillance protocols to monitor infections, and only 20% used multimodal strategies for IPC activities. Similarly, 70% of facilities had a TB-IPC program without a proper budget and did not include facility managers in the TB-IPC team; 80% indicated that patient flow poses a risk of TB transmission; 70% had poor ventilation systems; 90% had inadequate isolation rooms; and though 80% have personal protective equipment available, frequent shortages were reported.
Conclusions: The WHO-recommended TB-IPC policy is not effectively implemented in most of the participating district hospitals. Improvements in implementing and disseminating TB-IPC guidelines, monitoring TB-IPC practices, and systematic healthcare worker training are essential to improve TB-IPC guidelines’ operationalization in health settings to reduce TB's prevalence in PNG.
Text classification based on an improved graph neural network
Authors: Zhang Ruidong , Guo Zelin , Huan Hai 
Published: December 2022

Abstract
The purpose of text classification is to label the text with known labels. In recent years, the method based on graph neural network (GNN) has achieved good results. However, the existing methods based on GNN only regard the text as the set of co-occurring words, without considering the position information of each word in the statement. Meanwhile, this method mainly extracts node features, but neglects the use of edge features between nodes. To solve these problems, a new text classification method, graph convolutional network using positions and edges (PEGCN), is proposed. Position embedding is added in the word-embedding part so that the network can learn the relative position information between words. Meanwhile, the dimension of the adjacency matrix is increased to extract the multi-dimensional edge features. Through experiments on multiple text classification datasets, the proposed method is shown to be superior to the traditional text classification method, and has achieved a maximum improvement of more than 4%.