bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do values and political attitudes affect help-seeking? Exploring reported help-seeking for mental health problems in a general population sample using a milieu framework
Authors: Spahlholz J. , Baumann E. , Müller-Hilmer R. , Hilmer R. , Sander C. , Schindler S. , Speerforck S. , Angermeyer M. C. , Schomerus G. 
Published: August 2023

Abstract

Aims
Help-seeking for mental health problems is facilitated and hindered by several factors at the individual, interpersonal and community level. The most frequently researched factors contributing to differences in help-seeking behaviour are based on classical socio-demographic variables, such as age, gender and education, but explanations for the observed differences are often absent or remain vague. The present study complements traditional approaches in help-seeking research by introducing a milieu approach, focusing on values and political attitudes as a possible explanation for differences in help-seeking for emotional mental health problems.

Methods
A representative cross-sectional survey of N = 3,042 respondents in Germany was conducted through face-to-face interviews about past help-seeking for mental health problems, socio-demographic characteristics and values and political attitudes

Results
Multivariate logistic regression analyses indicated that belonging to a cosmopolitan intellectual milieu group was significantly associated with an increased likelihood of past help-seeking for mental health issues (psychotherapeutic/psychological help-seeking [OR = 2.09, 95% CI: 1.11–3.93, p < 0.05) and primary care (OR = 2.21, 95% CI: 1.15–4.24, p < 0.05]), whereas members of individualist and conservative milieu groups were less likely to report having sought help from a psychotherapist, but not from a general practitioner. Increased odds ratios were also found for a number of socio-demographic variables, such as being aged 26 years and over, a female gender and more than 12 years of formal education. Associations between socio-demographic variables remained significant, and the explained variance of the used models improved considerably when milieu variables were added.

Conclusions
We discuss how milieu-specific patterns were relevant for explaining differences in mental health service use in addition to socio-demographic factors. It seems promising to consider help-seeking from a milieu perspective to improve disparities in access to and the use of psychotherapy as well as to resource allocation.
ENSO‐Related Southern Hemisphere Blocking Dynamics
Authors: Zhang Bo , Dong Li , Ding Hairu , Xie Zhiang 
Published: August 2023

AbstractThis study establishes a new blocking climatology in the Southern Hemisphere (SH) by using the improved detection method with the reanalysis data from 1979 to 2016. Furthermore, it investigates the dynamical linkage between SH blocking and ENSO phases. It is found that the ENSO warm phase is more conducive to the blocking formation than the cold phase while the blocking intensity is not affected by the ENSO phases. In addition, blocking in ENSO warm phase is characterized with upper‐level divergence anomaly and the cold phase with convergence anomaly equatorward of blocking onset region. Through the diagnostic analysis of tropopause divergence for the composite blocking events via an improved divergence tendency equation, the study shows that the ageostrophic effect exhibits dual effects, namely, it induces anticyclonic ageostrophic vorticity favoring the formation of blocking whereas it results in convergence anomaly close to the blocking onset region thus inhibiting blocking locally. In addition, the nonlinear term in the divergence tendency equation is found to be a dominant forcing for favoring blocking onset. Nevertheless, despite the primary contributions from the ageostrophic effect and nonlinear term to blocking formation, they could barely explain the SH blocking onset preference in ENSO warm phase. Finally, through the localized Eliassen‐Palm flux this study reveals that in ENSO warm phase the composite blocking onset region and the immediate upstream region are characterized by more localized EP flux convergence, thereby leading to more effective westerly wind weakening and favoring the blocking formation.
The Nature of Opal Burial in the Equatorial Atlantic During the Deglaciation
Authors: Gil I. M. , McManus J. F. , Rebotim A. , Narciso A. , Salgueiro E. , Abrantes F. 
Published: August 2023

AbstractRelatively high opal concentrations are measured in equatorial Atlantic sediments from the most recent deglaciation. To shed light on their causes, seven cores were analyzed for their content of siliceous (diatom, silicoflagellates, radiolarians, phytoliths, and sponge spicules) and calcareous (coccolithophores) microfossils. An early deglacial signal is detected at the time of rising boreal summer insolation ca. 18 ka by the coccolithophores. The surface freshening is likely due to the rain belt associated with the intertropical convergence zone (ITCZ), implying its southward shift relatively to its present‐day average positioning. The diatom assemblages corresponding to the following increase in diatom abundances ca. 15.5 ka suggest the formation of a cold tongue of upwelled water associated with tropical instability waves propagating westward. Such conditions occur at present during boreal summer, when southerly trade winds are intensified, and the ITCZ shifts northward. The presence of the diatom Ethmodiscus rex (Wallich) Hendey and the coccolithophore Florisphera profunda indicates a deep thermocline and nutrient enrichment of the lower photic zone, revealing that Si‐rich southern sourced water (SSW) likely contributed to enhanced primary productivity during this time interval. The discrepancies between the maximum opal concentrations and siliceous marine microfossils records evidence the contribution of freshwater diatoms and phytoliths, indicative of other processes. The definition of the nature of the opal record suggests successive productivity conditions associated with specific atmospheric settings determining the latitudinal ITCZ positioning and the development of oceanic processes; and major oceanic circulation changes permitting the contribution of SSW to marine productivity at this latitude.
Glacial Isostatic Adjustment Modulates Lateral Migration Rate and Morphology of the Red River (North Dakota, USA and Manitoba, Canada)
Authors: Kodama Samuel T. , Pico Tamara , Finnegan Noah J. , Lapôtre Mathieu G. A. , Willenbring Jane K. 
Published: August 2023

AbstractThe lateral migration of a river meander is driven by erosion on the outer bank and deposition on the inner bank, both of which are affected by shear stress (and therefore channel slope) through complex morphodynamic feedbacks. To test the sensitivity of lateral migration to channel slope, we quantify slope change induced by glacial isostatic adjustment along the Red River (North Dakota, USA and Manitoba, Canada) and two of its tributaries over the past 8.5 ka. We demonstrate a statistically significant, positive relationship between normalized cutoff count, which we interpret as a proxy for channel lateral migration rate, and slope change. We interpret this relationship as the signature of slope change modulating the magnitude of shear stress on riverbanks, suggesting that slope changes that occur over thousands of years are recorded in river floodplain morphology.
Longitudinal pilot study of oxygen saturation indices in healthy preterm infants
Authors: Falconer Olivia , Ivy Savannah , Le Carpentier Dana , Gavlak Johanna , Liddle Natasha , Senior Emily , Lowe Paula , Crowley Philippa , Young Aneurin , Johnson Mark J. , Beattie Robert Mark , Evans Hazel J. 
Published: August 2023

Abstract
Background
This study aimed to determine patterns of nocturnal pulse oximetry indices in moderate to late preterm infants, and investigate the relationship between oxygen desaturations, the apnoea hypopnoea index, and both corrected gestational and postnatal age.

Methods
21 healthy infants born at 32 + 0 - 36 + 6 weeks gestation underwent serial nocturnal pulse oximetry studies and respiratory polygraphy studies until 40 weeks corrected gestational age (CGA). The main outcome measures were number of >3% oxygen desaturations/hour (ODI3), mean oxygen saturations, and number of apnoeas and hypopnoeas/hour.

Results
Median ODI3 increased between weeks 1 and 3 from 49.9 to 85.4/hour (p = 0.017). Mean oxygen saturations reached a corresponding nadir of 96.0% in week 3, then increased to 96.8% in week 6 (p = 0.019). Mixed effects modelling demonstrated that ODI3 and mean saturations were influenced by postnatal age but not CGA (p < 0.05). Desaturations frequently occurred without an apnoea or hypopnoea.

Conclusion
ODI3 rises then falls during the first 8 weeks of life in moderate to late preterm infants, independently of CGA. These interesting preliminary results highlight the importance of further serial data collection to generate age-specific normal ranges, and develop a better understanding of respiratory control in preterm infants.

Impact

The frequency of >3% oxygen desaturations (ODI3) in healthy moderate to late preterm infants rises then falls after birth, peaking in postnatal week 3. There is a corresponding nadir in mean saturations.

There were significant non-linear relationships between ODI3/mean saturations and postnatal age, but not corrected gestational age.

The majority of brief oxygen desaturations occurred without an apnoea or hypopnoea.

Normal ranges for oxygen saturation indices are not known in this population. These results demonstrate the need for further serial data collection to generate age-specific normal ranges and inform oxygen prescribing guidelines.
Low back pain and osteoarthritis pain: a perspective of estrogen
Authors: Pang Huiwen , Chen Shihui , Klyne David M. , Harrich David , Ding Wenyuan , Yang Sidong , Han Felicity Y. 
Published: August 2023

AbstractLow back pain (LBP) is the world’s leading cause of disability and is increasing in prevalence more rapidly than any other pain condition. Intervertebral disc (IVD) degeneration and facet joint osteoarthritis (FJOA) are two common causes of LBP, and both occur more frequently in elderly women than in other populations. Moreover, osteoarthritis (OA) and OA pain, regardless of the joint, are experienced by up to twice as many women as men, and this difference is amplified during menopause. Changes in estrogen may be an important contributor to these pain states. Receptors for estrogen have been found within IVD tissue and nearby joints, highlighting the potential roles of estrogen within and surrounding the IVDs and joints. In addition, estrogen supplementation has been shown to be effective at ameliorating IVD degeneration and OA progression, indicating its potential use as a therapeutic agent for people with LBP and OA pain. This review comprehensively examines the relationship between estrogen and these pain conditions by summarizing recent preclinical and clinical findings. The potential molecular mechanisms by which estrogen may relieve LBP associated with IVD degeneration and FJOA and OA pain are discussed.
SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway
Authors: Xu Ruiyuan , Song Jianlu , Ruze Rexiati , Chen Yuan , Yin Xinpeng , Wang Chengcheng , Zhao Yupei 
Published: August 2023

AbstractPancreatic cancer (PC), a highly lethal malignancy, commonly exhibits metabolic reprogramming that results in therapeutic vulnerabilities. Nevertheless, the mechanisms underlying the impacts of aberrant cholesterol metabolism on PC development and progression remain elusive. In this study, we found that squalene epoxidase (SQLE) is a crucial mediator of cholesterol metabolism in PC growth. We observed a profound upregulation of SQLE in PC tissues, and its high expression was correlated with poor patient outcomes. Our functional experiments demonstrated that SQLE facilitated cell proliferation, induced cell cycle progression, and inhibited apoptosis in vitro, while promoting tumor growth in vivo. Mechanistically, SQLE was found to have a dual role. First, its inhibition led to squalene accumulation-induced endoplasmic reticulum (ER) stress and subsequent apoptosis. Second, it enhanced de novo cholesterol biosynthesis and maintained lipid raft stability, thereby activating the Src/PI3K/Akt signaling pathway. Significantly, employing SQLE inhibitors effectively suppressed PC cell proliferation and xenograft tumor growth. In summary, this study reveals SQLE as a novel oncogene that promotes PC growth by mitigating ER stress and activating lipid raft-regulated Src/PI3K/Akt signaling pathway, highlighting the potential of SQLE as a therapeutic target for PC.
Realizing metallicity in Sr2IrO4 thin films by high-pressure oxygen annealing
Authors: Song Zhen , Zhang You-Shan , Shen Jing-Yi , Lin Bing , Wu Jie , Xiang Ping-Hua , Duan Chun-Gang , He Rui-Hua 
Published: August 2023

AbstractPerovskite iridates are a promising material platform for hosting unconventional superconductivity. Transport measurements of Sr2IrO4 thin-film field-effect transistors are expected to provide irrefutable evidence for the existence of superconductivity. However, these experiments have revealed a remarkably robust insulating state over wide electron and hole doping ranges; this finding is in contrast to the case of the bulk material, in which metallicity appears upon moderate electron doping by substituting cations in place of Sr. The nature of this robust insulating state and whether any metallic state can be realized in the Sr2IrO4 thin film are two remaining challenges that preclude further progress in the search for superconductivity in this system. Here, we show that this insulating state is enhanced in Sr2IrO4 thin films by thermal annealing under vacuum conditions, while it can be destroyed upon annealing in an oxygen atmosphere within restricted ranges of oxygen pressure, annealing temperature and ion substitution levels. The resulting films exhibit metallic transport behavior near room temperature and a metal–insulator crossover at ~200 K. Our results point to the potentially important roles of the oxygen vacancies at different atomic sites in the formation of the robust insulating state and the new metallic state and to their interplay in the Sr2IrO4 thin film. This finding opens new possibilities in the search for unconventional superconductivity by further tailoring the as-found metallic state in properly oxygen-annealed Sr2IrO4 thin films.
CRISPR/sgRNA-directed synergistic activation mediator (SAM) as a therapeutic tool for Parkinson´s disease
Authors: Narváez-Pérez Luis Fernando , Paz-Bermúdez Francisco , Avalos-Fuentes José Arturo , Campos-Romo Aurelio , Florán-Garduño Benjamín , Segovia José 
Published: August 2023

AbstractParkinson`s disease (PD) is the second most prevalent neurodegenerative disease, and different gene therapy strategies have been used as experimental treatments. As a proof-of-concept for the treatment of PD, we used SAM, a CRISPR gene activation system, to activate the endogenous tyrosine hydroxylase gene (th) of astrocytes to produce dopamine (DA) in the striatum of 6-OHDA-lesioned rats. Potential sgRNAs within the rat th promoter region were tested, and the expression of the Th protein was determined in the C6 glial cell line. Employing pseudo-lentivirus, the SAM complex and the selected sgRNA were transferred into cultures of rat astrocytes, and gene expression and Th protein synthesis were ascertained; furthermore, DA release into the culture medium was determined by HPLC. The DA-producing astrocytes were implanted into the striatum of 6-OHDA hemiparkinsonian rats. We observed motor behavior improvement in the lesioned rats that received DA-astrocytes compared to lesioned rats receiving astrocytes that did not produce DA. Our data indicate that the SAM-induced expression of the astrocyte´s endogenous th gene can generate DA-producing astrocytes that effectively reduce the motor asymmetry induced by the lesion.
Superscattering emerging from the physics of bound states in the continuum
Authors: Canós Valero Adrià , Shamkhi Hadi K. , Kupriianov Anton S. , Weiss Thomas , Pavlov Alexander A. , Redka Dmitrii , Bobrovs Vjaceslavs , Kivshar Yuri , Shalin Alexander S. 
Published: August 2023

AbstractWe study the Mie-like scattering from an open subwavelength resonator made of a high-index dielectric material, when its parameters are tuned to the regime of interfering resonances. We uncover a novel mechanism of superscattering, closely linked to strong coupling of the resonant modes and described by the physics of bound states in the continuum (BICs). We demonstrate that the enhanced scattering occurs due to constructive interference described by the Friedrich-Wintgen mechanism of interfering resonances, allowing to push the scattering cross section of a multipole resonance beyond the currently established limit. We develop a general non-Hermitian model to describe interfering resonances of the quasi-normal modes, and study subwavelength dielectric nonspherical resonators exhibiting avoided crossing resonances associated with quasi-BIC states. We confirm our theoretical findings by a scattering experiment conducted in the microwave frequency range. Our results reveal a new strategy to boost scattering from non-Hermitian systems, suggesting important implications for metadevices.
A translational regulator MHZ9 modulates ethylene signaling in rice
Authors: Huang Yi-Hua , Han Jia-Qi , Ma Biao , Cao Wu-Qiang , Li Xin-Kai , Xiong Qing , Zhao He , Zhao Rui , Zhang Xun , Zhou Yang , Wei Wei , Tao Jian-Jun , Zhang Wan-Ke , Qian Wenfeng , Chen Shou-Yi , Yang Chao , Yin Cui-Cui , Zhang Jin-Song 
Published: August 2023

AbstractEthylene plays essential roles in rice growth, development and stress adaptation. Translational control of ethylene signaling remains unclear in rice. Here, through analysis of an ethylene-response mutant mhz9, we identified a glycine-tyrosine-phenylalanine (GYF) domain protein MHZ9, which positively regulates ethylene signaling at translational level in rice. MHZ9 is localized in RNA processing bodies. The C-terminal domain of MHZ9 interacts with OsEIN2, a central regulator of rice ethylene signaling, and the N-terminal domain directly binds to the OsEBF1/2 mRNAs for translational inhibition, allowing accumulation of transcription factor OsEIL1 to activate the downstream signaling. RNA-IP seq and CLIP-seq analyses reveal that MHZ9 associates with hundreds of RNAs. Ribo-seq analysis indicates that MHZ9 is required for the regulation of ~ 90% of genes translationally affected by ethylene. Our study identifies a translational regulator MHZ9, which mediates translational regulation of genes in response to ethylene, facilitating stress adaptation and trait improvement in rice.
wMel replacement of dengue-competent mosquitoes is robust to near-term climate change
Authors: Vásquez Váleri N. , Kueppers Lara M. , Rašić Gordana , Marshall John M. 
Published: August 2023

AbstractRising temperatures are impacting the range and prevalence of mosquito-borne diseases. A promising biocontrol technology replaces wild mosquitoes with those carrying the virus-blocking Wolbachia bacterium. Because the most widely used strain, wMel, is adversely affected by heat stress, we examined how global warming may influence wMel-based replacement. We simulated interventions in two locations with successful field trials using Coupled Model Intercomparison Project Phase 5 climate projections and historical temperature records, integrating empirical data on wMel’s thermal sensitivity into a model of Aedes aegypti population dynamics to evaluate introgression and persistence over one year. We show that in Cairns, Australia, climatic futures necessitate operational adaptations for heatwaves exceeding two weeks. In Nha Trang, Vietnam, projected heatwaves of three weeks and longer eliminate wMel under the most stringent assumptions of that symbiont’s thermal limits. We conclude that this technology is generally robust to near-term (2030s) climate change. Accelerated warming may challenge this in the 2050s and beyond.
Pixel-level annotated dataset of computed tomography angiography images of acute pulmonary embolism
Authors: de Andrade João Mario Clementin , Olescki Gabriel , Escuissato Dante Luiz , Oliveira Lucas Ferrari , Basso Ana Carolina Nicolleti , Salvador Gabriel Lucca 
Published: August 2023

AbstractPulmonary embolism has a high incidence and mortality, especially if undiagnosed. The examination of choice for diagnosing the disease is computed tomography pulmonary angiography. As many factors can lead to misinterpretations and diagnostic errors, different groups are utilizing deep learning methods to help improve this process. The diagnostic accuracy of these methods tends to increase by augmenting the training dataset. Deep learning methods can potentially benefit from the use of images acquired with devices from different vendors. To the best of our knowledge, we have developed the first public dataset annotated at the pixel and image levels and the first pixel-level annotated dataset to contain examinations performed with equipment from Toshiba and GE. This dataset includes 40 examinations, half performed with each piece of equipment, representing samples from two medical services. We also included measurements related to the cardiac and circulatory consequences of pulmonary embolism. We encourage the use of this dataset to develop, evaluate and compare the performance of new AI algorithms designed to diagnose PE.
EUSEDcollab: a network of data from European catchments to monitor net soil erosion by water
Authors: Matthews Francis , Verstraeten Gert , Borrelli Pasquale , Vanmaercke Matthias , Poesen Jean , Steegen An , Degré Aurore , Rodríguez Belén Cárceles , Bielders Charles , Franke Christine , Alary Claire , Zumr David , Patault Edouard , Nadal-Romero Estela , Smolska Ewa , Licciardello Feliciana , Swerts Gilles , Thodsen Hans , Casalí Javier , Eslava Javier , Richet Jean-Baptiste , Ouvry Jean-François , Farguell Joaquim , Święchowicz Jolanta , Nunes João Pedro , Pak Lai Ting , Liakos Leonidas , Campo-Bescós Miguel A. , Żelazny Mirosław , Delaporte Morgan , Pineux Nathalie , Henin Nathan , Bezak Nejc , Lana-Renault Noemí , Tzoraki Ourania , Giménez Rafael , Li Tailin , Zuazo Víctor Hugo Durán , Bagarello Vincenzo , Pampalone Vincenzo , Ferro Vito , Úbeda Xavier , Panagos Panos 
Published: August 2023

AbstractAs a network of researchers we release an open-access database (EUSEDcollab) of water discharge and suspended sediment yield time series records collected in small to medium sized catchments in Europe. EUSEDcollab is compiled to overcome the scarcity of open-access data at relevant spatial scales for studies on runoff, soil loss by water erosion and sediment delivery. Multi-source measurement data from numerous researchers and institutions were harmonised into a common time series and metadata structure. Data reuse is facilitated through accompanying metadata descriptors providing background technical information for each monitoring station setup. Across ten European countries, EUSEDcollab covers over 1600 catchment years of data from 245 catchments at event (11 catchments), daily (22 catchments) and monthly (212 catchments) temporal resolution, and is unique in its focus on small to medium catchment drainage areas (median = 43 km2, min = 0.04 km2, max = 817 km2) with applicability for soil erosion research. We release this database with the aim of uniting people, knowledge and data through the European Union Soil Observatory (EUSO).