bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topographies of Fungibility: Reinventing the Japanese Taste for Sweetness in the Philippine Highlands
Authors: Paredes Alyssa 
Published: January 2025

Abstract
Japan is the only place in the world where bananas are marketed and priced by cultivation altitude. In the late 1980s, plantation managers sourcing the fruit from the southern Philippine region of Mindanao discovered a paradigm-shifting formula: the higher up one grew, the sweeter the bananas became. And the sweeter the bananas were, the closer they were to replicating the taste of colonial Taiwanese bananas, lost in the switch to Philippine supply. This paper offers the first transnational history of the banana’s transition along the spectrum from a fungible commodity to a nonfungible product in the Asia-Pacific region. Engaging critical studies of commodities and plantations, it takes fungibility as the characteristic that makes goods interchangeable and as the principle that renders landscape and labor as empty vessels open to the projection of others’ desires. The paper argues that the introduction of kōchi saibai banana or “highland cultivated bananas” for the Japanese market brought not the reversal of fungible life to the Philippine highlands but rather its continuation. In so doing, this work critiques conceptual frameworks that understand fungibility through the idioms of liquidification and immateriality. Instead, it proposes a topographical approach, which sees processes of fungibilization as operating through the profoundly material rearrangement of human and environmental communities. By focusing on the tensions between fungibility and differentiation, this paper offers an account of both an idiosyncratic marketing strategy particular to the Philippines and Japan, and a dynamic that pervades the creation of all commodities under capitalism.
Dialogue: The Role of the Editor
Authors: Burt Philippa , Shevtsova Maria 
Published: January 2025

World-renowned New Theatre Quarterly celebrates its fifty years of publication and its 200th issue, this being the last under the editorship of Maria Shevtsova. Simon Trussler, founder of Theatre Quarterly in 1971 (which closed for lack of funding in 1981) always considered New Theatre Quarterly, established with Cambridge University Press in 1985 – and with Clive Barker as co-editor – to be simply a continuation of TQ. Maria Shevtsova fully agreed. Forty issues of TQ, combined with one hundred and sixty editions of NTQ, gives the magic figure 200. The logistics of things, however, means that the number 160 appears on the cover of the present issue (the ‘New’ in New Theatre Quarterly standing for the newly resurgent journal on the back of its predecessor). This present issue also celebrates Maria Shevtsova’s twenty years of co-editorship with Simon Trussler, together with five more years of sole editorship of the journal following his death in 2019 (commemorated in NTQ 142, May 2020; see also their respective editorials, ‘One Hundred Issues and After’, in NTQ 100, November 2009).Twenty-five years of absolute commitment and tireless work call for recognition and thanks. Assistant editor Philippa Burt here discusses with Shevtsova her vision for the journal, and how her scholarship, research, teaching, as well as her numerous academic and outreach activities in multiple media, connected with her editorial commitment. This conversation took place on 19 June 2024.
How strong is the relationship between caregiver speech and language development? A meta-analysis
Authors: Coffey Joseph R. , Snedeker Jesse 
Published: January 2025

Abstract
A growing body of research has found that talking to young children is positively associated with language outcomes. However, there is tremendous heterogeneity in the design of these studies, which could potentially affect the strength and reliability of this association. The present meta-analysis, comprising 4760 participants across 71 studies, goes beyond prior research by including: 1) more recent studies, 2) non-English-speaking populations, 3) more fine-grained categorization of measures of input, 4) additional moderators, and 5) a multilevel model design allowing us to consider multiple effect sizes per study. We find a moderate association between input and outcomes (R2=0.04-0.07) across four input measures, with some evidence of publication bias. We find no differences in effect size across any of the input measures. Child age and study duration moderated some effects of input. Our findings suggest that language input-outcome associations remain robust but modest across a multitude of contexts and measures.
Beyond One-Size-Fits-All: A Person-Centred Approach to Bridging South Korea’s Digital Divide
Authors: Yoo Myunghyun , Lee Jinju 
Published: January 2025

Abstract
This study employed a person-centred approach to investigate the digital divide in South Korea and its impact on life satisfaction among individuals. Six latent profiles were identified based on the following factors: digital device literacy, social capital, and digital self-efficacy. These factors denote different levels of the digital divide, highlighting the multifaceted nature of this issue and the importance of considering multiple factors that contribute to inequality. Additionally, sociodemographic variables such as age, gender, and educational level were found to play a role in determining group membership, emphasising the need to understand the underlying causes of the divide. Variations in life satisfaction among the groups emphasise their different effects on well-being. The findings can be used to inform targeted policies and interventions to bridge the digital divide in South Korea. To that end, this study provides data for designing tailored education, social networking, and support policies for vulnerable groups.
A Feminine or Masculine Crisis? Gender Stereotypes and Leadership During a Pandemic
Authors: Kantorowicz-Reznichenko Elena , Dabrowska Justyna , Kantorowicz Jaroslaw 
Published: January 2025

Abstract
The COVID-19 pandemic posed new challenges for leaders, requiring behavior change and public self-compliance. Stereotypically feminine qualities, such as compassion and a good approach to people, may have helped achieve these goals, rendering the pandemic a “feminine crisis.” The special nature of this crisis, along with media attention on female-led countries successfully managing the pandemic, raises the question of whether female leaders would be perceived as more competent in handling such a crisis. In an experimental study conducted on a representative sample in Poland, we assessed whether female prime minister candidates or candidates with feminine traits had an advantage when their competence in managing a large-scale pandemic was evaluated. Surprisingly, we found that, contrary to national security and economic crises (where male or masculine candidates tend to be advantaged), women or feminine candidates were not perceived as having an advantage in managing a COVID-19 type crisis. Furthermore, conservative participants seemed to perceive male candidates as more competent, even in the pandemic context. Although the differences were small in magnitude, they suggest that even in a potentially “feminine crisis,” women do not fare better than men, while men still fare better in stereotypically male crises.
Prognostic value of biomarkers of ischaemia in patients with peripheral arterial disease following endovascular revascularisation
Authors: Dobrilovič Nika , Gerbec Nuša , Pelicon Kevin , Petek Klemen , Blinc Aleš , Boc Vinko , Jug Borut , Mijovski Mojca Božič , Osredkar Joško , Kejžar Nataša , Boc Anja 
Published: January 2025

Summary: Background: Our aim was to evaluate the prognostic value of detectable high-sensitivity cardiac troponin I (hs-cTnI) and ischaemia-modified albumin (IMA) in predicting all-cause death or non-fatal ischaemic events in patients with PAD after endovascular revascularisation of the lower limbs. Patients and methods: Patients who underwent successful endovascular revascularisation for chronic limb-threatening ischaemia (CLTI) or disabling intermittent claudication (IC) were prospectively included. Pre-procedural levels of hs-cTnI and IMA were measured, and patients were followed for one year for the occurrence of the composite outcome of all-cause death, non-fatal myocardial infarction, new-onset angina, non-fatal ischaemic stroke, transient ischaemic attack, or progression of PAD. Outcomes were evaluated using survival analyses. Results: A total of 487 patients concluded the study, of whom 175 (35.9%) experienced the composite outcome. When considering only the clinical presentation of PAD and biomarker values, in patients with CLTI, hs-cTnI above the limit of detection (LoD) conferred an increased risk of the composite outcome compared to hs-cTnI below the LoD (p=0.004), while for IMA we found no significant difference. Outcomes of patients with CLTI and hs-cTnI or IMA below the LoD did not differ from those of patients with IC (p=0.07 and p=0.462, respectively). When adjusting for clinical characteristics and common cardiovascular risk factors in multivariate Cox survival analysis, neither biomarker improved prognostic performance, however IMA emerged as an independent predictor of the composite outcome in patients with CLTI. Conclusions: In patients with PAD who underwent successful endovascular procedure, neither IMA nor hs-cTnI improved risk stratification beyond clinical determinants. However, detection of IMA was an independent predictor of major cardiovascular events or death in patients with CLTI.
A New Capillary and Adsorption‒Force Model Predicting Hydraulic Conductivity of Soil During Freeze‒thaw Processes
Authors: Qiao Shufeng , Ma Rui , Wang Yunquan , Sun Ziyong , French Helen Kristine , Wang Yanxin 
Published: January 2025

AbstractUnderstanding the change in soil hydraulic conductivity with temperature is key to predicting groundwater flow and solute transport in cold regions. The most commonly used models for hydraulic conductivity during freeze‒thaw cycles only consider the flow of capillary water in the soil and neglect water flowing along thin films around the particle surface. This paper proposed a new hydraulic conductivity model of frozen soil via the Clausius–Clapeyron equation based on an unsaturated soil hydraulic conductivity model over the entire moisture range using an analogy between freeze‒thaw and dry‒wet processes in soils. The new model used a single equation to describe the conductivity behaviors resulting from both capillary and adsorption forces, thus accounting for the effect of both capillary water and thin liquid film around soil. By comparison with other existing models, the results demonstrated that the new model is applicable to various types of soils and that the predicted hydraulic conductivity is in the highest agreement with the observed data, while reducing the root mean square error by 38.9% compared to the van Genuchten–Mualem model. Finally, our new model was validated with thermal–hydrological benchmark problem and laboratory experiment result. The benchmark results indicated that the advective heat transfer was more significant, and the phase change was completed earlier when considering both capillary and adsorption forces than when only considering capillary forces. Furthermore, the coupled flow–heat model with the new hydraulic conductivity expression replicated well the results from a laboratory column experiment.
Transforming undergraduate dental education: the impact of artificial intelligence
Authors: Harte Molly , Carey Barbara , Feng Qingmei Joy , Alqarni Ali , Albuquerque Rui 
Published: January 2025

AbstractArtificial intelligence (AI) is a rapidly evolving area, having had a transformative effect within some areas of medicine and dentistry. In dentistry, AI systems are contributing to clinical decision-making, diagnostics and treatment planning. Ongoing advances in AI technology will lead to further expansion of its existing applications and more widespread use within the field of dentistry. The predicted transformation of current practice within dentistry brought about by AI necessitates the education of undergraduate dental students on the topic of AI. AI will act as a complementary tool to clinical expertise and skill, rather than a replacement. AI education frameworks should integrate with existing traditional dental education. It is important that dental students develop a sound understanding of the ethical considerations surrounding AI, ensuring its safe and responsible use. This article aims to consider the status of current undergraduate dental education and the possible impact of AI, examining both the challenges and opportunities, and the practicalities, of incorporating AI into existing undergraduate dental curricula. Understanding and envisioning the future landscape shaped by AI will allow for development of a future dental workforce who are skilled, confident and responsible AI users.
Tenascin-C promotes bone regeneration via inflammatory macrophages
Authors: Ren Qian , Xing Wenhui , Jiang Bo , Feng Heng , Hu Xuye , Suo Jinlong , Wang Lijun , Zou Weiguo 
Published: January 2025

AbstractDuring the early stage of tissue injury, macrophages play important roles in the activation of stem cells for further regeneration. However, the regulation of macrophages during bone regeneration remains unclear. Here, the extracellular matrix (ECM) tenascin-C (TNC) is found to express in the periosteum and recruit inflammatory macrophages. TNC-deficiency in the periosteum delays bone repair. Transplantation of macrophages derived from injured periosteum is able to rescue the decreased skeletal stem cells and impaired bone regeneration caused by TNC deficiency. The cell communication analysis identifies ITGA7 as a TNC receptor contributing to the recruitment of inflammatory macrophages. TNC expression declines in aged mice and the exogenous delivery of TNC significantly promotes bone regeneration after aging through the recruitment of macrophages. Taken together, this study reveals the regulation of macrophage recruitment and its function in the activation of skeletal stem cells after bone injury, providing a strategy to accelerate bone regeneration by TNC delivery.
Small-molecule-induced ERBB4 activation to treat heart failure
Authors: Cools Julie M. T. , Goovaerts Bo K. , Feyen Eline , Van den Bogaert Siel , Fu Yile , Civati Céline , Van fraeyenhove Jens , Tubeeckx Michiel R. L. , Ott Jasper , Nguyen Long , Wülfers Eike M. , Van Berlo Benji , De Vries Antoine A. F. , Vandersickel Nele , Pijnappels Daniël A. , Audenaert Dominique , Roderick H. Llewelyn , De Winter Hans , De Keulenaer Gilles W. , Segers Vincent F. M. 
Published: January 2025

AbstractHeart failure is a common and deadly disease requiring new treatments. The neuregulin-1/ERBB4 pathway offers cardioprotective benefits, but using recombinant neuregulin-1 as therapy has limitations due to the need for intravenous delivery and lack of receptor specificity. We hypothesize that small-molecule activation of ERBB4 could protect against heart damage and fibrosis. To test this, we conduct a screening of 10,240 compounds and identify eight structurally similar ones (EF-1 to EF-8) that induce ERBB4 dimerization, with EF-1 being the most effective. EF-1 reduces cell death and hypertrophy in cardiomyocytes and decreases collagen production in cardiac fibroblasts in an ERBB4-dependent manner. In wild-type mice, EF-1 inhibits angiotensin-II-induced fibrosis in males and females and reduces heart damage caused by doxorubicin and myocardial infarction in females, but not in Erbb4-null mice. This study shows that small-molecule ERBB4 activation is feasible and may lead to a novel class of drugs for treating heart failure.
Seasonal changes of mélange thickness coincide with Greenland calving dynamics
Authors: Meng Yue , Lai Ching-Yao , Culberg Riley , Shahin Michael G. , Stearns Leigh A. , Burton Justin C. , Nissanka Kavinda 
Published: January 2025

AbstractIceberg calving is a major contributor to Greenland’s ice mass loss. Ice mélange, tightly packed sea ice and icebergs, has been hypothesized to buttress the calving fronts. However, quantifying the mélange buttressing force from field observations remains a challenge. Here we show that such quantification can be achieved with a single field measurement: thickness of mélange at the glacier terminus. We develop a three-dimensional discrete element model of mélange along with a simple analytical model to quantify the mélange buttressing using mélange thickness data from ArcticDEM over 32 Greenland glacier termini. We observed a strong seasonality in mélange thickness: thin mélange (averaged thickness $$3{4}_{-15}^{+17}$$
3

4

−
15

+
17

m) in summertime when terminus retreats, and thick mélange (averaged thickness $$11{9}_{-37}^{+31}$$
11

9

−
37

+
31

m) in wintertime when terminus advances. The observed seasonal changes of mélange thickness strongly coincide with observed Greenland calving dynamics and the modeled buttressing effects.
Sitravatinib in combination with nivolumab plus ipilimumab in patients with advanced clear cell renal cell carcinoma: a phase 1 trial
Authors: Msaouel Pavlos , Yu Kai , Yuan Ying , Chen Jianfeng , Yan Xinmiao , Karki Menuka , Duan Fei , Sheth Rahul A. , Rao Priya , Sircar Kanishka , Shah Amishi Y. , Zurita Amado J. , Genovese Giannicola , Li Min , Yeh Chih-Chen , Dang Minghao , Han Guangchun , Chu Yanshuo , Hallin Max , Olson Peter , Yang Rui , Slavin Daniela , Der-Torossian Hirak , Chin Curtis D. , Tannir Nizar M. , Wang Linghua , Gao Jianjun 
Published: January 2025

AbstractWe conducted a phase I trial to determine the optimal dose of triplet therapy with the tyrosine kinase inhibitor sitravatinib plus nivolumab plus ipilimumab in 22 previously untreated patients with advanced clear cell renal cell carcinoma. The primary endpoint was safety. Secondary endpoints were objective response rate (ORR), disease control rate (DCR), duration of response (DOR), progression-free survival (PFS), overall survival (OS), 1-year survival probability, and sitravatinib pharmacokinetics. Sitravatinib dose of 35 mg daily plus nivolumab 3 mg/kg and ipilimumab 1 mg/kg resulted in high frequency of immune-related adverse events. Subsequent dose reduction of ipilimumab to 0.7 mg/kg allowed safe escalation of sitravatinib up to 100 mg daily. Overall, the triplet combination achieved ORR 45.5%, DCR 86.4%, median PFS 14.5 months, and 1-year survival 80.8%. Median OS and DOR were not reached. Sitravatinib exposure increased dose-dependently. Single-cell RNA-seq of longitudinally collected tumor biopsies from 12 patients identified a tumor cell-specific epithelial-mesenchymal transition-like program associated with treatment resistance and poor outcomes. Treatment resistance was characterized by a transition from cytotoxic to exhausted T cell state and enrichment for M2-like myeloid cells. The observed hypothesis-generating changes in gene expression dynamics and cellular states may help inform future strategies to optimize immunotherapy efficacy. Clinical Trials.gov identifier: NCT04518046
COVID-19’s gendered effect on subjective wellbeing in MENA countries
Authors: Barsoum Ghada , Majbouri Mahdi 
Published: January 2025

AbstractThe COVID-19 pandemic has been a time of great intensity that exposed many existing inequities in facing this global threat. Building on Galtung’s conceptualization of positive peace as the absence of structural violence and institutionalized inequality, we study the gendered effect of the COVID-19 pandemic on reported subjective wellbeing (SWB) in four countries in the Middle East. Data from mobile phone panel surveys, with a total sample of 12,614 observations collected during this critical juncture, show that women consistently reported a lower level of SWB than men in all four countries. Women experienced higher increases in unemployment rates than men in all four countries, despite their already higher rates prior to the pandemic. Controlling for individual characteristics and geographic-time fixed effects, the main factor associated with lower SWB was the decline in household income, reflecting the intersectionality of poverty and gender. In addition, the reported increase in the time spent on housework negatively affected women’s SWB, particularly in urban areas. The pandemic has further accentuated gender inequality in all four countries and exposed the inherent structural violence experienced by women in these contexts.
Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation
Authors: Kassubek Jan , Roselli Francesco , Witzel Simon , Dorst Johannes , Ludolph Albert C. , Rasche Volker , Vernikouskaya Ina , Müller Hans-Peter 
Published: January 2025

AbstractPrimary lateral sclerosis (PLS) is a motor neuron disease (MND) which mainly affects upper motor neurons. Within the MND spectrum, PLS is much more slowly progressive than amyotrophic laterals sclerosis (ALS). `Classical` ALS is characterized by catabolism and abnormal energy metabolism preceding onset of motor symptoms, and previous studies indicated that the disease progression of ALS involves hypothalamic atrophy. Very limited weight loss is observed in patients with PLS, which raises the question of whether there are also less hypothalamic alterations. The purpose of this study was to quantitatively investigate the hypothalamic volume in a group of PLS patients and to compare it with ALS and controls. Recently, we have introduced automatic hypothalamic quantification method based on the use of convolutional neural network (CNN) to reduce human variability and enhance analysis robustness. This CNN of U-Net architecture was applied for automatic segmentation of the hypothalamus and intracranial volume (ICV) to allow adjustments of the hypothalamic volume between subjects with different head sizes respectively. Automatic segmentation and volumetric analysis were performed in high resolution T1 weighted MRI volumes (acquired on a 1.5 T MRI scanner) of 46 PLS patients in comparison to 107 healthy controls and 411 `classical` ALS patients, respectively. Significant hypothalamic volume reduction was observed in PLS (818 ± 73 mm3) when compared to controls (852 ± 77 mm3); significant hypothalamic volume reduction was also confirmed in ALS (823 ± 84 mm3), in support of previous studies. No significant differences were found in normalized hypothalamic volumes between ALS patients and PLS patients at the group level. This unbiased CNN-based hypothalamus volume quantification study demonstrated similarly reduced hypothalamus volume in PLS and ALS patients, despite the clinical phenotypic differences.
A unifying principle for global greenness patterns and trends
Authors: Cai Wenjia , Zhu Ziqi , Harrison Sandy P. , Ryu Youngryel , Wang Han , Zhou Boya , Prentice Iain Colin 
Published: January 2025

AbstractVegetation cover regulates the exchanges of energy, water and carbon between land and atmosphere. Remotely-sensed fractional absorbed photosynthetically active radiation (fAPAR), a land-surface greenness measure, depends on carbon allocation to foliage while also controlling photon flux for photosynthesis. Here we use an equation with just two globally fitted parameters to describe annual maximum fAPAR as the smaller of a water-limited value transpiring a constant fraction of annual precipitation, and an energy-limited value maximizing annual plant growth. This minimalist description reproduces global greenness patterns and temporal trends in remote-sensing data, comparable to the best-performing dynamic global vegetation models. Widely observed greening is attributed principally to the influence of rising carbon dioxide on the light- and water-use efficiencies of photosynthesis; limited browning regions are attributed to drying. This research provides one key component of ecosystem function as a step towards more robust foundations for new-generation land ecosystem models.