bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clear vision: a step towards unravelling student recruitment in English universities?
Authors: Gandy Robert , Wolstencroft Peter , Geer Katherine , de Main Leanne 
Published: July 2023

Purpose The recruitment of undergraduate students within English universities is of vital importance to both the academic success and the financial stability of the organisation. Despite the primacy of the task, there has been a dearth of research looking at related performance and how to ensure that the process is optimised. The purpose of this study was to investigate the degree of variation both within a university and between different universities. The reliance that individual programmes and/or universities place on the Clearing process is key; given its uncertainty, resource demands and timing shortly before students take up their places.Design/methodology/approach The Nomogramma di Gandy diagrammatical approach utilises readily available data to analyse universities’ performance in recruiting students to different programmes, and the degree to which they each rely of the Clearing process. Inter-university performance was investigated on a whole-student intake basis for a sample of English universities, representative of type and region.Findings The study found that there were disparate patterns for the many programmes within the pilot university and also disparate patterns between different types of universities across England. Accordingly, universities should internally benchmark their programmes to inform both strategic and tactical decision-making. Similarly, Universities and Colleges Admissions Service benchmarking inter-university patterns could inform the overall sector.Originality/value The approach and findings provide lessons for analysing student recruitment which could be critical to universities’ academic and financial health, in an increasingly competitive environment.
Do firms manage earnings after a downgrade in their credit rating?
Authors: Koerniadi Hardjo 
Published: July 2023

Purpose
This paper aims to examine whether firms engage in earnings management immediately after experiencing a downgrade in their credit rating.

Design/methodology/approach
This paper uses fixed-effects regression models to examine real- and accrual-based earnings management after firms experience a downgrade in their credit rating.

Findings
Inconsistent with prior studies where firms are reported to opportunistically increase their earnings prior to a credit rating event, this paper finds that firms use income-decreasing earnings management after their ratings are downgraded. This paper also finds that firms downgraded to below the investment grade rating not only significantly reduce both abnormal cash flows and discretionary accruals but also report larger asset impairments, suggesting that these firms exploit the rating downgrade to employ a big bath accounting.

Practical implications
The results of this paper have practical implications for investors fixating on firm earnings after a credit rating downgrade, for shareholders of downgraded firms and regulators such as credit rating agencies.

Originality/value
The findings of this study contribute to the thin literature on earnings management after changes in credit rating by shedding lights on earnings management after a rating downgrade and complement the literature on the accounting choice of financially distressed firms. The empirical evidence documented in this study suggests that the occurrence of income-decreasing earnings management is not limited to only after a sovereign country rating downgrade as documented in a prior study but also occurs after a rating downgrade not associated with this event.
Competence in multiple foreign languages as cultural capital in family language policy: Parents’ perceptions
Authors: Xu Hao , Li Xia , Shan Zhibin 
Published: July 2023

AbstractFamily language policy for children's foreign language learning has emerged as an important topic for research on language education policy and second language learning in general. Whilst there is no shortage of studies that examine how parents engage in the formation and transformation of family foreign language education policies, little has been known as to how parents perceive the value of multilingual competence which influences their decisions about how their children's foreign language learning should be planned and resourced. Drawing on Bourdieu's concept of cultural capital, this multiple‐case study explored the perceptions of the parents from 16 middle‐class families with children aged 6–14 in Shanghai via interviews (with their children as well) and textual data. Data analysis reveals that parents perceived the language‐derived cultural capital as measured by its exchangeable social benefits at present or in the future. Their perceptions were thus divided as manifested in the three distinctive approaches they took to conceptualize their children's competence in multiple foreign languages as cultural capital, that is, the extra‐point view (language competence as advantage), immediate deficiency view (lack of such competence as immediate disadvantage), and prospective deficiency view (lack of competence as disadvantage in a future scenario).
Extending Finlay–Wilkinson regression with environmental covariates
Authors: Piepho Hans‐Peter , Blancon Justin 
Published: July 2023

AbstractFinlay–Wilkinson regression is a popular method for analysing genotype–environment interaction in series of plant breeding and variety trials. It involves a regression on the environmental mean, indexing the productivity of an environment, which is driven by a wide array of environmental factors. Increasingly, it is becoming feasible to characterize environments explicitly using observable environmental covariates. Hence, there is mounting interest to replace the environmental index with an explicit regression on such observable environmental covariates. This paper reviews the development of such methods. The focus is on parsimonious models that allow replacing the environmental index by regression on synthetic environmental covariates formed as linear combinations of a larger number of observable environmental covariates. Two new methods are proposed for obtaining such synthetic covariates, which may be integrated into genotype‐specific regression models, that is, criss‐cross regression and a factor‐analytic approach. The main advantage of such explicit modelling is that predictions can be made also for new environments where trials have not been conducted. A published dataset is employed to illustrate the proposed methods.
Severity scoring system to guide transfusion management in pediatric non‐deletional HbH
Authors: Songdej Duantida , Tandhansakul Manunya , Wongwerawattanakoon Pakawan , Sirachainan Nongnuch , Charoenkwan Pimlak , Chuansumrit Ampaiwan 
Published: July 2023

AbstractBackgroundHemoglobin (Hb) H is generally recognized as mild thalassemia, despite its actual phenotypic diversity. A disease severity scoring system to guide initiation of regular transfusion among severely affected pediatric patients has not previously been reported.MethodsPatients with HbH were classified into transfusion‐dependent thalassemia (TDT) and non‐transfusion‐dependent thalassemia (NTDT) as a surrogate for disease severity. Alpha‐globin genotypes and relevant clinical parameters associated with TDT were identified. Univariate and multiple logistic regression analyses were performed to yield the most suitable severity scoring system.ResultsFrom 246 patients with a median age of 14.3 (interquartile range 9.9–18.4) years initially enrolled into the study, the chance of having severe disease and developing TDT was remarkable only among patients with non‐deletional HbH, for whom the scoring system was developed. Univariate and multiple logistic regression analyses resulted in three retained parameters associated with TDT, β‐coefficients of which were used to develop the score. The final scoring system comprised age at diagnosis <2 years (score = 1), spleen size ≥3 cm (score = 1) and Hb at steady‐state <7 (score = 4) or 7–8 g/dL (score = 3). A cutoff score ≥4 was associated with severe disease likely requiring regular transfusion (sensitivity 89.3%, specificity 81.4%), given regular transfusion resulted in maintained growth. The scoring system was validated in the second cohort of 77 non‐deletional HbH, from which comparable sensitivity and specificity were obtained.ConclusionThe newly developed scoring system was practical and helpful to highlight severely affected pediatric non‐deletional HbH patients with potential needs of regular transfusion. This can be used as a guide for optimal treatment and disease monitoring in the future.
High expression of RPL27A predicts poor prognosis in patients with hepatocellular carcinoma
Authors: Xing Huiwu , Jiang Xiangqi , Yang Chenyu , Tan Bingqian , Hu Jiqiang , Zhang Mingman 
Published: July 2023

Abstract
Background
Hepatocellular carcinoma (HCC) is one of the most common cancers in the digestive system with rapid progression and poor prognosis. Recent studies have shown that RPL27A could be used as a biomarker for a variety of cancers, but its role in HCC is not clear.

Method
We analyzed the expression of RPL27A in the pan-cancer analysis and analyzed the relationship between the expression of RPL27A and the clinical features and prognosis of patients with HCC. We evaluated the expression difference of RPL27A in HCC tissues and paired normal adjacent tissues using immunohistochemistry. Furthermore, we analyzed the co-expression genes of RPL27A and used them to explore the possible mechanism of RPL27A and screen hub genes effecting HCC. In addition, we studied the role of RPL27A in immune infiltration and mutation.

Results
We found that the expression level of RPL27A increased in a variety of cancers, including HCC. In HCC patients, the high expression of RPL27A was related to progression and poor prognosis as an independent predictor. We also constructed a protein interaction network through co-expression gene analysis of RPL27A and screened 9 hub genes. Enrichment analysis showed that co-expression genes were associated with ribosome pathway, viral replication, nuclear-transcribed mRNA catabolic process, and nonsense-mediated decay. We found that the expression level of RPL27A was closely related to TP53 mutation and immune infiltration in HCC.

Conclusion
RPL27A might become a biomarker in the diagnosis, treatment, and follow-up of patients with HCC.
Neutrophil extracellular traps promote angiogenesis in gastric cancer
Authors: Yang Shifeng , Sun Boshi , Li Jiacheng , Li Nana , Zhang Ange , Zhang Xinyu , Yang Hao , Zou Xiaoming 
Published: July 2023

AbstractAlthough antiangiogenic therapy has been used in gastric cancer, disease progression due to drug resistance remains common. Neutrophils play an important role in the occurrence and progression of cancer via neutrophil extracellular traps (NETs). However, few studies have investigated angiogenic regulation in gastric cancer. We aimed to determine the role of NETs in promoting angiogenesis in gastric cancer. Multiple immunohistochemical staining was used to analyze the spatial distribution of NETs and microvessels in patient tissue samples. A mouse subcutaneous tumor model was established to determine the effect of NETs on tumor growth, and changes in microvessel density were observed via immunohistochemical staining. We screened differentially expressed proteins in HUVECs stimulated by NETs via proteomics. Cell Counting Kit-8, EdU labeling, and tubule formation assays were used to verify the effect of NETs on HUVEC proliferation, migration, and tubule formation. Blocking NETs, which was related to decreased microvessel density, significantly inhibited tumor growth in the murine subcutaneous tumor model. Compared with those of the control group, tumor volume and mass among mice in the inhibition group decreased by 61.3% and 77.9%, respectively. The NET-DNA receptor CCDC25 was expressed in HUVECs, providing a platform for NETs to promote HUVEC proliferation, migration, and tubulation. In an in vitro rat aortic explant model, NETs induced HUVEC proliferation, survival, and chemotaxis, which were not significantly different from those observed in the VEGF stimulation group. Our results confirm that NETs promote angiogenesis in gastric cancer, providing a theoretical basis for identifying new anti-vascular therapeutic targets.
Graphical Abstract
Sargassum sp. as a biofertilizer: is it really a key towards sustainable agriculture for The Bahamas?
Authors: Adderley Aaliyah , Wallace Shonnel , Stubbs Danica , Bowen-O’Connor Clare , Ferguson Joseph , Watson Carlton , Gustave Williamson 
Published: July 2023

Abstract
Background
Macroalgae blooms (Sargassum sp.) occur annually in The Bahamas due to the integration of various events related to human intercession with the roles of algae in biogeochemical cycles. These blooms are of great concern, as they are associated with many negative effects; thus, the primary aims of this study were to assess the quality of soils collected from South, Central, and North Long Island, and to determine whether Sargassum sp. can be used as a biofertilizer for soils on Long Island. A 60-day pot trial method was established to determine the efficacy of different concentrations (1%, 5%, and 10%) of Sargassum sp. as a biofertilizer on cherry tomato cultivation. Additionally, the soil quality before and after fertilizer amendment was evaluated.

Results
The results show that Sargassum sp. increased nutrient content of the soil, specifically nitrate nitrogen and phosphorus; however, plant growth performance parameters (plant height, leaf number, bud number, flower number, and root and shoot weights) were negatively affected.

Conclusions
Due to the obtained results, it is recommended that serious consideration be taken when utilizing Sargassum sp. as a biofertilizer because the pH and type of soil in Long Island, Bahamas, affects the bioavailability of the nutrients released from the algae.

Graphical abstract
TMEM41A overexpression correlates with poor prognosis and immune alterations in patients with endometrial carcinoma
Authors: Shi Ke , Liu Xiao-Li , Guo Qiang , Zhang Yun-Qiang , Fan Si-Tong , Dai Ling , Jiang Ni , Li Dan 
Published: July 2023

Background
Expression levels of transmembrane protein 41A (TMEM41A) are related to the progression of malignant tumors. However, the association between TMEM41A expression and endometrial carcinoma (EC) remains unclear. This study aims to identify the roles of TMEM41A expression in the prognosis of patients with EC and its correlation with EC progression.

Methods
The TMEM41A expression and its correlation with the survival of patients with EC were assessed. Cox regression analysis was used to identify the prognostic factors, while nomograms were used to examine the association between the prognostic factors and the survival of patients with EC. Finally, the link between TMEM41A level and immune microenvironment and RNA modifications was investigated in EC.

Results
TMEM41A was overexpressed in EC. TMEM41A overexpression could diagnose the EC and evaluate the poor prognosis of patients. Overexpression of TMEM41A was associated with clinical stage, age, weight, histological subtype, tumor grade, and survival status of patients with EC. Clinical stage, age, tumor grade, radiotherapy, and TMEM41A overexpression were factors of poor prognosis in patients with EC. The nomograms revealed the correlation between the TMEM41A level and survival time of patients with EC at 1, 3, and 5 years. Furthermore, TMEM41A overexpression was significantly correlated with the level of the stromal score, immune score, estimate score, NK CD56 bright cells, iDC, NK cells, eosinophils, pDC, T cells, TReg, cytotoxic cells, mast cells, Th17 cells, neutrophils, aDC, NK CD56 dim cells, TFH, Th2 cells, CD8 T cells, macrophages, immune cell markers, and RNA modifications.

Conclusions
TMEM41A is overexpressed in EC tissues and is associated with the prognosis, immune microenvironment, and RNA modification. Our preliminary studies indicate that overexpression of TMEM41A can potentially serve as a biomarker for EC treatment.
DDI-SSL: Drug–Drug Interaction Prediction Based on Substructure Signature Learning
Authors: Liang Yuan 
Published: July 2023

Drugs-drugs interactions(DDI) are entities composed of different chemical substructures
(functional groups). In existing methods that predict drug–drug interactions based on the usage of
substructures, each node is considered the center of a substructure, and adjacent nodes eventually
become centers of similar substructures, resulting in redundancy. Furthermore, the significant differ-
ences in structure and properties among compounds can lead to unrelated pairings, making it difficult
to integrate information. This heterogeneity negatively affects the prediction results. To address
these issues, we propose a drug–drug interaction prediction method based on substructure signature
learning (DDI-SSL). This method extracts useful information from local subgraphs surrounding drugs
and effectively utilizes substructures to assist in predicting drug side effects. Additionally, a deep
clustering algorithm is used to aggregate similar substructures, allowing any individual subgraph to
be reconstructed using this set of global signatures. Furthermore, we developed a layer-independent
collaborative attention mechanism to model the mutual influence between drugs, generating signal
strength scores for each class of drugs to mitigate noise caused by heterogeneity. Finally, we evaluated
DDI-SSL on a comprehensive dataset and demonstrated improved performance in DDI prediction
compared to state-of-the-art methods.
KEBIJAKAN FASILITASI HAK KEKAYAAN INTELEKTUAL OLEH BADAN EKONOMI KREATIF (BEKRAF) DALAM PENGUATAN UMUM BIDANG EKONOMI KREATIF
Authors: Herdyanto Rizky 
Published: July 2023

<p align="center"><strong><em>Abstract</em></strong></p><p><em>This legal research describes whether Badan Ekonomi Kreatif , especially the Deputy of Intellectual Property Rights and Regulations, has run its program in facilitating Intellectual Property owned by creative economy performers in Indonesia. This research uses descriptive empirical legal research methods. The results of this research indicate that Bekraf has greatly assisted Creative Economic actors in obtaining legal protection over their products. The problem experienced by Bekraf is the lack of coordination between Bekraf and its partners, creative economy actors who put aside the importance of IPR, as well as communal products of Geographycal Indications that are contrary to IPR Principles. The Ministry of Tourism and Creative Economy hopefully hopefully can continue Bekraf’s Intellectual Property Facilitation and disseminating IPR on a periodic basics for the creative economy actors.</em></p><p><strong><em>Keywords: </em></strong><strong><em>Intellectual Property Rights; Bekraf</em></strong><strong><em>; Facilitation; Creative Economy.</em></strong></p><p><em> </em></p><p align="center"><strong>Abstrak</strong></p><p>Penulisan hukum ini mengkaji apakah Badan Ekonomi Kreatif khususnya Deputi Fasilitasi Hak Kekayaan Intelektual dan Regulasi sudah menjalankan programnya dalam memfasilitasi Kekayaan Intelektual milik pelaku ekonomi kreatif di Indonesia<em>. </em>Penulisan ini menggunakan metode penelitian hukum empiris bersifat deskriptif. Hasil penelitian ini menunjukan bahwa Bekraf melalui programnya sudah membantu para pelaku ekonomi kreatif dalam memperoleh kekuatan hukum atas produk maupun ciptaannya. Hambatan yang dialami Bekraf berupa kurangnya koordinasi antara Bekraf dan mitra kerja, pelaku ekonomi kreatif yang mengesampingkan pentingnya Kekayaan Intelektual, serta produk komunal Indikasi Geografis yang bertentangan dengan prinsip HKI. Kementrian Pariwisata dan Ekonomi Kreatif diharapkan dapat melanjutkan program Bekraf dalam Fasilitasi Kekayaan Intelektual dan melakukan sosialisasi HKI secara periodik terhadap pelaku ekonomi kreatif.</p><p><strong>Kata Kunci: Hak Kekayaan Intelektual; Bekraf; Fasilitasi; Ekonomi Kreatif.</strong></p>
EFEKTIVITAS PRINSIP FIRST TO FILE PADA SISTEM PENDAFTARAN MEREK DALAM MELINDUNGI HAK MEREK
Authors: Kusumahwardhana Raden Fajar Agung 
Published: July 2023

<p><em>The purpose of writing this article aims is to find out how the effectiveness of the implementation of the First To File principle in the trademark registration system and what problems arise from the application of the First To File principle in protecting trademark rights in Indonesia.This research is descriptive analytical as a description of a situation, and provides data about a situation. Collecting data in this writing is done in literature by examining data consisting of primary legal material and secondary legal material, then the data is analyzed using normative-qualitative methods.The results of the writing of this article indicate that Law Number 21 of 1961 concerning Company Marks and Commercial Trademarks which adhere to the First To Use system has been replaced by Law Number 19 of 1992 concerning Trademarks which applies the First To File principle. The First To File principle in the trademark registration system provides more legal certainty because it appoints the first registrant as the legal owner of a mark if it has passed a series of mark registration and has a trademark certificate, but in its implementation there are problems with the absence of clear and firm norms related to the application of "equality in essence. "So as to open up opportunities for the emergence of popularity of Well-Known Mark.</em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><em>: Intellectual Property Rights; Trademark; First To File.</em></p>
PENGATURAN ARBITRASE SEBAGAI PENYELESAIAN SENGKETA ALTERNATIVE SECARA ONLINE
Authors: Sitepu Rehulina 
Published: July 2023

<p><strong>ABSTRAK: </strong>Penyelesaian sengketa alternative secara online dilakukan dengan menggabungkan informasi pengolahan teknologi komputer dengan fasilitas jaringan komunikasi internet. Yang menjadi permasalahannya adalah bagaimana pengaturan arbitrase sebagai penyelesaian sengketa alternatif secara online<strong> </strong>berasarkan peraturan perundang-undangan yang ada di Indonesia saat ini sesuai dengan perkembangan dan kebutuhan masyarkat? Metode penelitian yang dipakai adalah penelitian hukum normative dengan menggunakan sumber penelitian adalah data sekunder yang terdiri atas bahan hukum primer, bahan hukum sekunder dan bahan hukum tersier. Pengaturan Penyelesaian Sengketa Melalui Penyelesaian Sengketa Alternatif Berdasarkan UU Nomor 30 Tahun 1999 Tentang Arbitrase Dan Penyelesaian Sengketa Alternatif yang menyebutkan bahwa dengan melakukan pertukaran surat, pertukaran teleks, fkasimil, <em>e-mail</em> dan atau bentuk sarana komunikasi lainnya yang disertai dengan suatu catatan penerimaan oleh para pihak yang bersenkgeta.</p>