bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intolerance-of-uncertainty therapy versus metacognitive therapy for generalized anxiety disorder in primary health care: A randomized controlled pilot trial
Authors: af Winklerfelt Hammarberg Sandra , Toth-Pal Eva , Jansson-Fröjmark Markus , Lundgren Tobias , Westman Jeanette , Bohman Benjamin 
Published: June 2023

Objective
This randomized controlled pilot study investigated the feasibility of a future full-scale RCT to compare the effects of intolerance-of-uncertainty therapy (IUT) and metacognitive therapy (MCT) in primary health care patients with generalized anxiety disorder (GAD). Preliminary treatment effects were also evaluated.

Materials and methods
64 patients with GAD at a large primary health care center in Stockholm, Sweden, were randomized to IUT or MCT. Feasibility outcomes included participant recruitment and retention, willingness to receive psychological treatment, and therapists’ competence in and adherence to treatment protocols. Self-reported scales were used to assess treatment outcomes, including worry, depression, functional impairment, and quality of life.

Results
Recruitment was satisfactory, and dropout was low. On a scale from 0 to 6, participants were satisfied with participating in the study (M = 5.17, SD = 1.09). Following brief training, therapists’ competence was rated as moderate, and adherence was rated as weak to moderate. From pre- to post-treatment, reductions on the primary treatment outcome measure of worry were of a large effect size and statistically significant in both the IUT and MCT conditions (Cohen’s d for IUT = -2.69, 95% confidence interval [-3.63, -1.76] and d for MCT = -3.78 [-4.68, -2.90]). The between-group effect size from pre- to post-treatment was large and statistically significant (d = -2.03 [-3.31, -0.75]), in favor of the MCT condition.

Conclusion
It is feasible to carry out a full-scale RCT to compare the effects of IUT to MCT for patients with GAD in primary health care. Both protocols seem effective, and MCT seems superior to IUT, but a full-scale RCT is needed to confirm these conclusions.

Trial registration
ClinicalTrials.gov (no. NCT03621371).
Giant duplication of the transverse colon in an adult: A case report and literature review
Authors: Peng Zhihao , Zhang Mingkai , Wang Ruixue , Huang Hai , Sun Zongke , Li Yanbin 
Published: June 2023

Abstract
Intestinal duplication is a rare congenital malformation that can occur in any segment of the digestive tract. It is most commonly found in the ileum of infants and is rarely reported in adults, especially in the colon. Diagnosing intestinal duplication can be extremely challenging due to its diverse clinical manifestations and complex anatomical structure. Surgical intervention is currently considered the mainstay of treatment. In this report, we presented a case of giant duplication of the transverse colon in an adult.
In vitro antiproliferative efficacy of Annona muricata seed and fruit extracts on several cancer cell lines
Authors: Almutairi Bader O. , Mater Ahmed Sholiah , Abutaha Nael , Almutairi Mikhlid H. 
Published: June 2023

Abstract
In Saudi Arabia, breast cancer is the second-most frequently identified common malignant cause of death for women. The present investigation was carried out to assess the impact of different Soxhlet solvent extracts of Annona muricata on apoptosis induction in breast cancer cells. Cell survival was estimated by post-incubation of cells with the extract for 24 h using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay. Acridine orange (AO)/propidium iodide (PI) and 4′,6-diamidino-2-phenylindole (DAPI) staining were employed to study cell apoptosis. qRT-PCR was also employed to assess apoptotic genes’ expression, such as BAX and P53 genes. The results of the MTT assay showed that the chloroform extract inhibited the proliferation of MDA-MB-231 and MCF-7 cells dose-dependently. AO/PI and DAPI staining showed chromatin condensation and fragmentation. In treated cells, P53 expression significantly increased, correlated with the increase in BAX activity. The findings suggest that apoptosis may have been triggered post-chloroform extract treatment. Combining chloroform extract of A. muricata and doxorubicin at a 1:1 ratio increased the IC50 value (292.3 µg/mL). The chloroform extract of A. muricata contained a variety of substances, including diethyl carbonate (7.38%), 4-acetoxy-2,11-dodecadiene (58.13%), and hexadecanoic acid (34.48%), according to the results of the gas chromatography-mass spectrometry analysis. As a result, future research on the A. muricata chloroform extract as a potential anticancer drug could be suggested.
Development of a fuzzy logic model for the prediction of spark-ignition engine performance and emission for gasoline–ethanol blends
Authors: Kaliyaperumal Manikandan , Sundaresan Ramabalan , Pandian Balu , Rajendran Silambarasan 
Published: June 2023

Abstract
Due to the enormous of fossil fuels and the ensuing increase in automobiles, an unprecedented scenario has arisen with pollution levels that are out of human control. In this study, a fuzzy logic model is developed to predict how well a spark-ignition engine running on gasoline and ethanol mixes would operate. A test engine was operated on pure gasoline and gasoline–ethanol fuel mixtures in a range of ratios at varying engine speeds. In order to estimate outputs such as brake-specific fuel consumption (BSFC), brake thermal efficiency, nitrogen oxides (NOx), hydrocarbon emissions, and carbon monoxide, a fuzzy logic model, a sort of logic model application, has been developed using experimental data. The developed fuzzy logic model’s output was compared to the results of the trials to see how well it performed. The output parameters were indicated, including braking power, thermal, volumetric, and mechanical efficiency. The input parameters were engine speed and ethanol mixes. Regression coefficients were nearly equal for training and testing data. According to the study, a superior method for accurately forecasting engine performance is the fuzzy logic model. To eliminate proportionality signs from equations, regression analysis is used. It is accurate to develop mathematical relations based on dimensional analysis. Based on the root mean square errors, BSFC is a minimum of 6.12 and brake power is a maximum of 8.16; lower than 2% of errors occur on average.
Translation in pre-trial phases of the judicial process: developing a norm-based framework to train translators working into Arabic
Authors: Halimi Sonia Asmahène 
Published: June 2023

AbstractThe present study examines the implications of judicial translation in the context of international migration and its relationship with the law of the host country. In this context, judicial translation involves highly sensitive documents that can be as varied as family registers and statutory declarations. It also refers to specific legal instances of interaction with judicial authorities in which the observance of certain communication norms is of paramount importance. This is particularly true in the strict setting of a judicial interview. This paper describes how translation is performed in a pre-trial police interview in which the communication of certain basic legal obligations becomes challenging for a migrant person, due to differences in legal backgrounds. In such a situation, the main question is as follows: how can differences in basic legal notions be dealt with in the particularly strict setting of a judicial interview with the assistance of a translator? To answer this question, the study focuses on a threefold challenge for the translator, who must be equipped to handle language, translation and legal/ethical norms. It proposes a translation framework based on these norms and the way in which they are applied in a real interview. It seeks to guide the translation task and serve as a tool for judicial translation training. With regard to the translation norm, the study shows that discursive creation is to be the most relevant technique to represent concepts that do not have counterparts in the target language. Although the foreign element in the new terminology may Ahighlight the boundary between the foreign law and the target legal institution, this technique also leads to the creation of new concepts in the target institution.
Existence results for some generalized Sigmoid Beverton-Holt models in time scales
Authors: Abdelahi Mariem Mohamed , Sambe Mohamed Ahmed , Moulay Ely Elkhomeini 
Published: June 2023

Abstract
In this article, we investigate some generalized Sigmoid Beverton-Holt models in time scales, and we obtain the existence and uniqueness of a globally attractive almost periodic solution to the associated dynamic equations with or without survival rates under some suitable assumptions. An example is given to illustrate our abstract results.
Optimized Cu2O-{100} facet for generation of different reactive oxidative species via peroxymonosulfate activation at specific pH values to efficient acetaminophen removal
Authors: Chen Ke , Yang Xudong , Hao Rui , Shao Minghui , Yang Xiaoyong , Li Xiuze , Li Yuxuan , Liu Juzhe , Zhang Sai 
Published: June 2023

Abstract
Activation of peroxymonosulfate (PMS) to degrade persistent organic contaminants has received increasing attention in wastewater purification. In this study, Cu2O catalysts with different exposed crystal facets were prepared, characterized, and evaluated for acetaminophen (ACE) degradation through PMS activation. The experimental results showed that cubic Cu2O with {100} facets exhibited remarkable activity on ACE removal by PMS activation in wide pH range of 3–11. DFT calculations indicated that Cu2O-{100} displayed higher electron transfer efficiency and PMS adsorption ability, further improving PMS activation. The radicals quenching experiments and electron paramagnetic resonance (EPR) results illustrated that singlet oxygen (1O2) was dominant reactive oxidative species (ROSs) during oxidation reactions and the relevant generation pathways were distinctly elucidated. Finally, the possible PMS activation mechanisms were discussed for ACE degradation in a wide pH range. This study will provide new insights to disclose PMS-based advanced oxidation processes (AOPs), and offer a new approach for wastewater purification by non-radical reactions.
Two-part vowel modifications in Child Directed Speech in Warlpiri may enhance child attention to speech and scaffold noun acquisition
Authors: Bundgaard-Nielsen Rikke L. , O’Shannessy Carmel , Wang Yizhou , Nelson Alice , Bartlett Jessie , Davis Vanessa 
Published: June 2023

AbstractStudy 1 compared vowels in Child Directed Speech (CDS; child ages 25–46 months) to vowels in Adult Directed Speech (ADS) in natural conversation in the Australian Indigenous language Warlpiri, which has three vowels (/i/, /a/, /u). Study 2 compared the vowels of the child interlocutors from Study 1 to caregiver ADS and CDS. Study 1 indicates that Warlpiri CDS vowels are characterised by fronting, /a/-lowering,fo-raising, and increased duration, but not vowel space expansion. Vowels in CDS nouns, however, show increased between-contrast differentiation and reduced within-contrast variation, similar to what has been reported for other languages. We argue that this two-part CDS modification process serves a dual purpose: Vowel space shifting induces IDS/CDS that sounds more child-like, which may enhance child attention to speech, while increased between-contrast differentiation and reduced within-contrast variation in nouns may serve didactic purposes by providing high-quality information about lexical specifications. Study 2 indicates that Warlpiri CDS vowels are more like child vowels, providing indirect evidence that aspects of CDS may serve non-linguistic purposes simultaneously with other aspects serving linguistic-didactic purposes. The studies have novel implications for the way CDS vowel modifications are considered and highlight the necessity of naturalistic data collection, novel analyses, and typological diversity.
Synthesis of non-ionic surfactants nano-vesicles for clarithromycin oral delivery
Authors: Ali Imdad , Khan Sarzamin , Ahmed Samrein , Khan Serab , Ali Heyam Saad , Shafiullah Raiz Ullah , Shah Muhammad Raza , Shah Zafar Ali 
Published: June 2023

Abstract
In order to improve the solubility and bioavailability of poorly water-soluble drugs, the synthesis of cost-effective nonionic surfactants has been the subject of greater scientific interest. The present study focuses on the synthesis of sulfonyl chloride derivatives as nonionic surfactants (surfactant 1 and surfactant 2) and their evaluation for the preparation of a clarithromycin-loaded niosomal drug delivery system. Surfactants 1 and 2 were characterised by EI-MS and 1H NMR spectroscopy. The shape and size of the drug-loaded niosomal vesicles from the synthesised surfactants were examined by atomic force microscopy (AFM) and revealed a round morphology with an average size of (230.8 ± 2.35) nm and (248.1 ± 2.54) nm for the vesicles of surfactant 1 and surfactant 2, respectively. The zeta potential of surfactant 1-based niosomal vesicles was (– 7.70 ± 1.00) mV and that of surfactant 2 was (−14.6 ± 1.08) mV. The lower zeta potential values for surfactant 1 and surfactant 2-based niosomal vesicles showed that these vesicles were neutral and relatively stable. The vesicles of surfactant 1 and 2 have a capacity to entrap the drug of about (62 ± 2.26) % and (69.67 ± 3.23) %, respectively. The vesicles of surfactant 1 released the largest amount of drug, i.e. (70.00 ± 2.45) % at pH 1.2. Biocompatibility in human blood and toxic effects on various cell lines were also studied for surfactants 1 and 2, and they were found to be biocompatible and non-cytotoxic.
Control of Trading Gold in Investment Gold in the Republic of Poland: Conditions and Fundamental Dilemmas
Authors: Ofiarski Zbigniew 
Published: June 2023

Abstract
Investment gold and foreign-exchange gold are special forms of gold in legal terms. The adoption of such a status is related to the regulation of the legal and factual circulation of gold and the performance of financial control in this regard, which at various stages of trading takes the form of tax, customs and fiscal or foreign-exchange control. The rules and procedure for controlling gold trading are regulated by the provisions of tax, customs, banking and foreign-exchange law. The aim of this study is to analyze and evaluate the applicable provisions of EU and national law regulating the scope of the regulation of gold trading and its control by tax, customs and fiscal authorities and the National Bank of Poland. The essence and application of the most important control instruments are presented, which are individual foreign-exchange permits, notification of the intention to transport gold across the state border, and special records and public registers kept by entrepreneurs. The hypothesis about the basic objectives (ensuring the safety of trading and preventing money laundering offenses) and additional purposes (collecting statistical data necessary to construct the assumptions of the state monetary system, tightening the tax system) of gold-trading control was positively verified. The research primarily used the dogmatic-legal method, and a complementary historical-legal method was used to present the main directions of the evolution of legislation in the field of regulating gold trading.
Desempeño mecánico del concreto convencional reemplazando agregado grueso con polietileno de tereftalato
Authors: Sanabria Rojas Madelein Natalia , Gil Peláez Jhon Jairo , Duarte Barón Katherin 
Published: June 2023

En muchos países los residuos plásticos son una parte contaminante del medio ambiente, por tal razón es necesario buscar alternativas en las que se pueda reutilizar de forma masiva, para disminuirlos significativamente. En este proyecto de investigación se realizó una búsqueda de trabajos asociados a la temática, se analizaron las técnicas utilizadas y los resultados obtenidos, de manera que se recolectó el material necesario y mediante ensayos de laboratorio se fabricaron cilindros de concreto con distintas sustituciones de los agregados gruesos por residuos plásticos (PET); con el fin de comparar las resistencias y costos de los moldes de concreto celular y con residuos plásticos; y así determinar la viabilidad de los agregados de plásticos en el concreto celular. En cada una de las proporciones de residuos plásticos utilizados se observó una disminución del peso y menor costo, sin embargo, ninguno logró superar la resistencia mínima, comparada con un cilindro convencional, al ser sometido a las pruebas de compresión, siendo el tamaño de los residuos la mayor problemática para obtener buenos resultados. Para utilizar residuos de plástico en la mezcla de concreto tradicional, es recomendable, reducir el tamaño de la partícula para mejorar la cohesión de los materiales, es decir Polipropileno de Tereftalato triturado, que sirva para el diseño de sistemas estructurales y que obtengan una mayor resistencia, con esto la contaminación debida a residuos plásticos disminuiría significativamente.
Pathological and molecular investigation of canine distemper virus: Phylogenetic analysis of co-circulating genetic lineages in Türkiye
Authors: Karapınar Zeynep , İlhan Fatma , Usta Mustafa , Timurkan Mehmet Özkan 
Published: June 2023

AbstractCanine distemper virus (CDV) is a highly contagious virus that infects a wide variety of animals of carnivore species and may cause manifestations from subclinical infection to fatal disease. In this study, dogs clinically suspected having distemper were examined by reverse transcriptase-polymerase chain reaction (RT-PCR), histopathology and immuno-histochemistry. By histopathological examination, characteristic intracytoplasmic and/or intranuclear inclusion bodies were observed in the lung, stomach, small intestine, liver, kidney, spleen and central nervous system. Interstitial and broncho-interstitial pneumonia, gastroenteritis and encephalitis were revealed. CDV antigens were detected in all tissues with characteristic histopathological findings. The antigens were more abundant in the bronchial and bronchiolar epithelium and in the syntitial cells. Phylogenetic analyses were performed using the PCR-amplified partial sequences of the genes encoding the viral heamagglutinin and fusion proteins. The phylogenetic trees showed that the newly determined sequences were diverse and clustered within different lineages of the European or the Arctic strains.
Reconstructive surgeries in the case of the knee joint osteoarthritis
Authors: Popsuishapka Olexii , Lytvyshko Valerii , Pidgaiska Olga , Ashukina Nataliya , Romanenko Kostiantyn , Danуshchuk Zinaida 
Published: June 2023

Objective. To clarify the indications and volume of reconstructive surgeries under conditions of knee joint arthritis and to improve the methods of surgical correction of peri-articular deformations using an external rod fixator. Methods. During the last 10 years (2012‒2022), reconstructive surgeries were performed in 45 patients (49 joints). Indications for surgery were based on the study of pain and its localization, peri-articular deformation of the limb, ultrasound (USD) and X-ray examinations. Results. Indications for certain reconstructive surgical interventions on the knee joint are substantiated. The role of pathological changes of the meniscus in the development of knee joint arthritis has been determined. The positive clinical effect of paracapsular resection of the front part of the meniscus with hyperplastic growths of synovial tissue is shown. Deformation of the extremety (43 patients — with varus deformity, 2 — with valgus deformity) limited the function of the limb and caused pain. Surgical treatment in such cases were aimed at eliminating the deformation of the proximal part of the tibia. The types of osteotomies, the features of the author's rod external fixation device application, and the postoperative management of patients are presented. Due to external fixator, it is possible to perform, if necessary, angular correction of the limb axis during the period when the patient begins to walk with partial weight bearing, and the functional load of the limb makes it possible to achieve fusion of fragments within 3.5–4 months. A long-term positive clinical effect was obtained in 42 (93 %) patients. Conclusions. Indications for pathogenetic treatment should be based, first of all, on the identification of the source (or pathogenesis) of the pain syndrome, then on the analysis of the type and magnitude of peri-articular deformation of the limb, signs of functional insufficiency of the limb associated with it. In the third place, the X-ray signs should be analyzed. Elimination of angular peri-articular deformation of the limb has a positive effect on the course of knee arthritis, reduces pain, increases physical activity, and slows down the progression of cartilage destruction.
Validation of Pedi-IKDC scale and intercultural adaptation to Ukrainian language
Authors: Yakushkin Yevgen , Katsalap Yelizaveta , Khmyzov Sergij 
Published: June 2023

There are no questionnaires available in Ukrainian that can be used to objectify the results of treatment of orthopaedic and traumatological pathology of the knee joint in children. In world practice, subjective Pedi-IKDC and KOOS-Child scales are used for this purpose. Objective. Validation, intercultural adaptation and translation of the Pedi-IKDS scale in English (original) into Ukrainian for paediatric patients. Methods. Translation and adap­tation agreed with the copyright holder of the AOSSM test and performed according to the requirements of the Recommendations for the Cross-Cultural Adaptation of Health Status Measures of the American Academy of Orthopaedic Surgeons Institute for Work & Health. The translated and adapted questionnaire has been tested on a heterogeneous group of 10 children treated for knee pathology. The questionnaire has been adjusted. The participants (both sexes, aged 10–18 years) have been divided into two groups for validation: I — without knee pathology, tested once; II — with knee injuries and physical limitations, tested before and after treatment. Results. We obtained 50 questionnaires in group I (50 child­ren). Student's t-test has been chosen for the analysis of results. To compare the accuracy of the translation, a comparison has been made with the results of A.Y. Nasreddine's study (unpaired Student's t-test). The resulting differences between the original questionnaire and its translation have not been statistically significant (p = 0.966). Group II received 200 questionnaires. A paired Student's t-test has been chosen for analysis. Test results before and after treatment have been significantly different (t2 > tcrit, p < 0.001). The appropriateness and objectivity of the Pedi-IKDC questionnaire have been confirmed. Conclusions. The Pedi-IKDC test has been successfully translated into Ukrainian and adapted for use. The quality of adaptation has been confirmed and no statistically significant difference has been found compared to the results of the world stu­dies. Pedi-IKDC is recommended to be used in children with knee pathology for clinical and scientific purposes.