bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of groundwater suitability for irrigational utilization determined by distinct quality indices and information entropy theory in the Indian Sundarban region
Authors: Molla Sabir Hossain , ; Rukhsana 
Published: January 2023

Abstract

For sustainable agricultural practices, groundwater quality must be suitable for irrigation; otherwise, it can degrade soil and diminish crop production. The entropy information theory, several irrigational indices, multivariate statistics, GIS and geostatistics are used in this work to evaluate the geographical distribution and quality of groundwater in the Indian Sundarban region. 33 samples of groundwater have been collected in total, and they were evaluated for major cations, anions as well as other parameters like electrical conductivity (EC), soluble sodium percentage (SSP), potential salinity (PS), total dissolved solids (TDS), Kelly ratio (KR), Sodium absorption ratio (SAR), permeability index (PI), residual sodium carbonate (RSC), Magnesium Hazard (MH) and residual sodium bicarbonate (RSBC). The overall trend of the principal cations and anions is in the sequence of Na+≥ Mg2+≥ Ca2+≥ K2+and HCO3−≥ Cl−≥ NO3−≥ SO42−≥ F−, respectively, whereas the spatial variation of %Na, SAR, RSBC, and MH demonstrate very poor irrigation water quality, and spatial variation of KR, RSC, SSP, PI, and PS signifies that the irrigation water quality is excellent to good. The hydrochemical facies indicates that mixed type makes up the bulk (51.51%) of the water samples. Following the Wilcox plot, more than 75% of the water samples are good to doubtful; however, by the US salinity hazard map, roughly 60.60% of the samples had high salinity (C3-S1 zone). As per the entropy-weighted water quality index for irrigation (EWQII), 60.60% of samples possess good to average quality, while the remaining 39.40% (poor) require severe restrictions before use in agricultural operations. As a result, to assure sustainable agricultural development, in the research area, continuous monitoring and water resource management are required.
First report of Boeremia exigua on Mungbean (Vigna radiata L.) in Kashmir Himalayas
Authors: Rashid Uzma , Mughal M. Najeeb , Irfan Mohammad , Wani Tanveer A , Manghwar Hakim , Ali Qurban 
Published: January 2023

Abstract
Boeremia exigua causing Ascochyta leaf spot is the first report on mungbean, owing to substantial yield losses. The outbreak of this pathogen on mungbean is of concern because of its severity and seed-borne nature. After the disease become more severe, collections of Ascochyta leaf spot were obtained during investigation. Based on morphological characteristics and phylogenetic analysis of a combined ITS and β-tubulin sequence dataset, Boeremia exigua was reported as new pathogen to mungbean and therefore was introduced as new collection. Positive test results were obtained for this pathogen and the resulting PCR product sequences were submitted in GenBank (accession no. OM992361.1) and submission id of other sequence (2591999). Phylogenetic analysis in this study revealed that the observed isolates and Boeremia exigua formed a monophyletic group. Detailed descriptions as well as an updated phylogenetic history are provided to confirm the placement of this newly identified pathogen.
Inflation with very small tensor-to-scalar ratio
Authors: Hirano Koichi 
Published: January 2023

Abstract
We have investigated inflation models that predict a very small value of the tensor-to-scalar ratio, \(r\) . The spectral index \(n_s\) , and the tensor-to-scalar ratio $r$, are strictly constrained by the Planck data. $n_s$ and $r$ are sensitive to the shape and magnitude of the inflaton potential, respectively.The constraints by the Planck 2018 data combined with other cosmological observations are compared with the predictions from the inflation models regarding $n_s$ and $r$. Furthermore, we discuss the comparison of future tensor-to-scalar ratio data with predictions from the inflation models with a focus on part of the quantum fluctuation origin.
Development of a Genetically Encoded Magnetic Platform for Protein Purification
Authors: Wu Sha , Tian Jiesheng , Tang Zongwen , Huang Zekai , Hammock Bruce D. , Morisseau Christophe , Li Qing X. , Xu Ting 
Published: January 2023

Abstract
Background: Protein downstream processing remains a challenge in protein production, especially in low yields of products, in spite of ensuring effective disruption of cell and separation of target proteins. It is complicated, expensive and time-consuming. Here, we report a novel nano-bio-purification system for producing recombinant proteins of interest with automatic purification from engineered bacteria.
Results: This system employed a complete genetic engineering downstream processing platform for proteins at low expression levels, referred to as a genetically encoded magnetic platform (GEMP). GEMP consists of four elements as follows. (1) A truncated phage lambda lysis cassette (RRz/Rz1) is controllable for lysis of Magnetospirillum gryphiswaldense MSR-1 (host cell). (2) A surface-expressed nuclease (NucA) is to reduce viscosity of homogenate by hydrolyzing long chain nucleic acids. (3) A bacteriogenic magnetic nanoparticle, known as magnetosome, allows an easy separation system in a magnetic field. (4) An intein realizes abscissionof products (nanobodies against tetrabromobisphenol A) from magnetosome.
Conclusions: In this work, removal of most impurities and good recoveries of nanobodies (92%) greatly simplified the subsequent purification procedure. The system also facilitated the bioproduction of nanomaterials. The developed platform can substantially simplify industrial protein production and reduce its cost.
Exploring the core competencies of clinical nurses in Chinese tertiary hospitals: a qualitative content analysis
Authors: Chen Meihan , Wang Aiping , Zhou Baosen 
Published: January 2023

Abstract

Background: With the changes in social and medical environments and people's health needs, the nursing core competency should be updated and developed in a timely manner. This study aimed to identify the core competencies of nurses in Chinese tertiary hospitals under the new health development strategy.Methods: A qualitative study was conducted through qualitative content analysis. A purposive sample of 20 nurses and nursing managers from tertiary hospitals in China were interviewed.Results: Data analysis revealed 27 competencies, which were grouped into three major categories according to the Onion Model. These categories were motivation and traits (responsibility, enterprise, etc.), professional philosophy and values (professionalism, career perception, etc.), and knowledge and skills (clinical nursing competency, leadership and management competency, etc.).Conclusion: There is still a gap between the current core competencies of nurses in Chinese tertiary hospitals and the ideal, and there is still a need to continuously improve all competencies in the future to meet the needs of society and the people. Based on the results of each level of the Onion Model, it helps to understand nurses' competencies at different levels and provides guidance for core competency assessment and development.
NGF-NGFR communication inefficiency induces T Cell exhaustion impairing PD-1 immunotherapy in hepatocellular carcinoma
Authors: Yang Tongwang , Xu Qingguo , Xu Chuanshen , Wang Feng , Dai Deshu , Guan Ge , Zhang Yong , Wang Shuxian , Wang Jianhong , Bai Xiaoshuai , Jin Yan , Shi Shangheng , Li Xinqiang , Zhu Cunle , Chen Dexi , Wang Xin , Guo Yuan 
Published: January 2023

Abstract
The number of T cells that infiltrate tumor tissues in hepatocellular carcinoma (HCC) is significantly low. The molecular mechanism underlying T cell proliferation in tumor tissues is poorly understood. The present study revealed that during the process of T cell infiltration from adjacent tissues to tumor tissues, the NGF-NGFR communication inefficiency occurred in the tumor tissues of HCC patients. Importantly, the tumor cell-secreted NGF interacted with NGFR on the membranes of the infiltrated T cells, which promoted proliferation of these cells through mitotic spindle signal activation. Mechanistically, the mitotic spindle signal activation promoted the proliferation was mediated by the HDAC1 unclear trans-localization-inhibited PREX1 expression. Further, PD-1 mAb acted synergistically with the NGF-NGFR communication to suppress tumor progression in both mouse model and HCC patients. In addition, NGF–NGFR communication was positively correlated with the PD-1/PDL-1 expression. However, NGF and NGFR expressions were low in tumor tissues, which was responsible for the incursive clinicopathological features and the disappointing prognosis in HCC patients. Collectively, the results suggested that NGF-NGFR communication inefficiency impaired PD-1 mAb immunotherapy and could, therefore, be utilized as a novel therapeutic target in the treatment of HCC patients in clinical practice.
Both host and diet shape bacterial communities of predatory mites
Authors: Yan Hong , Wang Endong , Wei Guo-Shu , Zhang Bo , Xu Xuenong 
Published: January 2023

Abstract
Microbial communities, derived from food, ambient and inner, can affect host ecological adaption and evolution. Comparing with most of phytophagous arthropods, the diet of predators is pretty complex and varied. At a higher trophic level, there may be more opportunity for predators to develop specific microbiota which may also depend on the level of prey host specialization shown by the predators. To explore how diet sources affect host microbial communities and vary across predators species, we considered three types predators from the family of Phytoseiidae: polyphagous (Amblyseius orientalis Ehara, Neoseiulus barkeri Hughes and Amblyseius swirskii Athias-Henrio), oligophagous (Neoseiulus californicus McGregor), and monophagous (Phytoseiulus persimilis Athias-Henriot) predatory mites. The polyphagous species were fed on two types of diets, natural prey (Tetranychus urticae Koch) and alternative prey (Carpoglyphus lactis Linnaeus). By using 16S rRNA sequencing, we found that diet was the main source of microbiota in predatory mites, and that there was no clear effect of prey specialization. For the polyphagous mites, species had a larger impact than prey type on microbial composition. Unlike A. orientalis or N. barkeri which showed consistency in their microbiota regardless of prey type, prey switching significantly affected β-diversity of bacterial composition in A. swirskii, with 56% of the microbiota changing. In short, our results confirmed the substantial influence of diet on host microbial construction in predatory species but also highlighted species differences in shaping the microbiota which are not necessarily related to prey specialization.
High-throughput sequencing to detect the bacterial microbiome in Ixodes granulatus in China
Authors: Chen Bin , Jiang Dan-Dan , Liu Ya-Fang , Lu Xin-Yan , Yang Guo-Ping , Geng Ling , Wang Xuan , Ren Tian-Guang , Yang Xing 
Published: January 2023

Abstract
Background
Ixodes granulatus is of significant research value as the primary vector of Lyme disease in Asia, yet the bacterial community structure and diversity carried by these ticks have not been reported so far. Part of bacteria in ticks can affect tick development and the transmission of tick-borne pathogens. With the emergence of new pathogens, it is necessary to identify the bacterial microbiome carried by I. granulatus.
Methods
Ixodes granulatus were collected from rodent animals in the Binchuan, China. The bacterial DNA was extracted from non-engorged adult female I. granulatus. Sequencing of the V3-V4 regions of the 16S rRNA genes was performed using the Illumina NovaSeq sequencing platform. Initial data was assembled in FLASH, QIIME, and UCHIME algorithm. Uparse and MUSCLE software were used to annotate and analyze the effective data.
Result
The predominant phyla in all samples were Firmicutes, Proteobacteria, Actinobacteria, and Spirochaetota. The major genera were Spiroplasma, Staphylococcus, Candidatus-Lariskella, Corynebacterium, Ralstonia, Borreliella (Borrelia), Vibrio, Bacillus, and Listeria. Staphylococcus xylosus, Ralstonia pickettii, Corynebacterium mastitidis, Bryopsis hypnoides, and Vibrio metschnikovii were dominant bacterial species. The results demonstrated that there were discrepancies in bacterial microbiome richness and diversity among different individual ticks of the same species, and found a large number of pathogenic bacteria and opportunistic pathogens, yet Coxiella and Rickettsia were not detected.
Conclusion
The results presented here speculate that Spiroplasma is the endosymbiont of I. granulatus and competitively inhibits Borrelia. Our study suggested that Binchuan is at risk of Lyme disease transmission and needs to be taken seriously. These findings may serve fundamental knowledge for developing novel strategies to control ticks and their transmission of diseases.
Comparative observations of the hemostatic effects of bio-zeolite gauze and QuickClot Combat Gauze on massive hemorrhage with coagulopathy
Authors: Yang Hao-yang , Jia Yi-jun , Xiao Ny , Zhong Xin , Jiang Ren-qing , Ye Zhao , Du Wen-qiong , Li Tan-shi , Zong Zhao-wen 
Published: January 2023

Abstract
BACKGROUND
The presence of coagulopathy after bleeding negatively affects the hemostatic effects of gauze. In this study, we compared the hemostatic effects of bio-zeolite gauze (BZG) and QuickClot Combat Gauze (QCG) on massive hemorrhage complicated by coagulopathy.
Methods
In 30 rabbits, diluted coagulopathy was prepared by extraction of blood at a dose of 15 mL/kg body weight following infusion with saline three times the volume of blood loss. Then, simulated blast-induced pelvic injury was initiated to produce massive hemorrhage using a custom-made machine, as previously reported. The rabbits were then randomly allocated to three groups, namely A, B, and C, in which BZG, QCG, and ordinary gauze were used to prevent bleeding, respectively. The primary outcomes, including the immediate hemostasis rate, blood loss, and survival rate, were recorded at designated time points. Additionally, blood samples were taken for laboratory examinations, including conventional coagulation, thromboelastography, full blood count, blood biochemistry, and enzyme-linked immunosorbent assay.
Results
Animal models of diluted coagulopathy and major bleeding were successfully developed with decreased concentrations of coagulation factors XII and X. The overall effects of BZG were better than those of QCG and ordinary gauze, with a higher immediate hemostatic rate, less blood loss at 10 min and 30 min after gauze application, and higher red blood cell and platelet counts, higher maximum amplitude, lower R values, lower levels of creatinine, and lower levels of alanine aminotransferase at 30 min after gauze application. Furthermore, a higher survival rate was found in group A rabbits than in group B and group C rabbits at 90 min after gauze application.
Conclusions
BZG demonstrated better hemostatic performance than QCG and normal gauze for massive hemorrhage complicated by coagulopathy. BZG is a suitable hemostatic gauze for control of massive hemorrhage complicated by coagulopathy.
The impact of brain lesions on quality of life in patients with WHO CNS grade 3 or 4 glioma: A lesion-function and resting-state fMRI analysis
Authors: Heinzel Alexander , Filss Christian , Stoffels Gabriele , Lohmann Philipp , Friedrich Michel , Shah Nadim J , Caspers Svenja , Lucas Carolin Weiss , Ruge Maximilian I , Galldiks Norbert , Fink Gereon R , Langen Karl-Josef , Kocher Martin 
Published: January 2023

Abstract
Purpose
Following multimodality therapy, glioma patients may suffer from reduced health-related quality of life (QoL). It is largely unknown how different types and locations of tumor- and treatment-related brain lesions, as well as their relationship to white matter tracts and functional brain networks, affect QoL.
Methods
In 121 patients with pretreated gliomas of WHO CNS grades 3 or 4, structural MRI, O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET, resting-state functional MRI (rs-fMRI) and self-reported QoL questionnaires (EORTC QLQ-C30/BN20) were obtained. Resection cavities, T1-enhancing lesions, T2/FLAIR hyperintensities, and lesions with pathologically increased FET uptake were delineated. Effects of tumor lateralization, affection of white matter tracts and rs-fMRI network nodes by different types of lesions, and within rs-fMRI functional connectivity on QoL were analyzed.
Results
Gliomas of the right hemisphere were associated with significantly less favorable outcomes in physical, role, emotional and social functioning, compared to left-sided tumors. Most QoL scores correlated significantly with the affection of right-sided white-matter tracts by T2/FLAIR hyperintensities and with the loss of within-network functional connectivity of right-sided functional nodes. Tumors of the left hemisphere caused significantly more communication deficits.
Conclusion
In pretreated high-grade gliomas, right hemisphere rather than left hemisphere lesions are associated with decreased quality of life in most domains, except communication ability. These impairments are associated mainly with T2/FLAIR lesions affecting white matter tracts and functional nodal connectivity in the right hemisphere. The data suggest that sparing the right hemisphere from treatment-related tissue damage may improve quality of life in glioma patients.
Technology Importation, Institutional Environment and Industrial Upgrading: Evidence from China
Authors: Song Caixia , Qiao Cuixia 
Published: January 2023

Abstract
Considering the importance of technology for industrial structure upgrading, especially under the impetus of the fourth industrial revolution, the paper examines the impact of technology importation on industrial structure upgrading in 31 Chinese provinces from 2002 to 2020. It also emphasises the moderating role of institutional environment based on two dimensions of industrial upgrading. The findings indicate that technology importation has a positive effect on industrial advancement; however, its impact on industrial rationalisation is not significant. A higher-quality institutional environment can indirectly contribute to the impact of technology importation on industrial upgrading. Finally, the effects of technology importation and institutional environment on industrial upgrading vary with regions, and there are also differences in the moderating effects of different aspects of institutional quality. Therefore, the article suggests that technology should be introduced according to the institutional environment of different regions, and the government should develop personalised industrial upgrading strategies.
JEL Classification O33, O14, L16
Stability state of a Mediterranean coastal environment threatened by erosion: the case of the Djerba Island (Gulf of Gabes, SE-Tunisia)
Authors: Saïdi Hanen , Jhine Meyessa , Bjaoui Béchir 
Published: January 2023

Abstract
The Djerba Island (Gulf of Gabes, SE-Tunisia) that is part of the South Rive of the Mediterranean is classified lately as an international heritage site. Despite this, it suffers from erosion. So, it's necessary to study and monitor its stability state (erosion/accretion) to predict future erosion. In the present work, the stability state was determined by studying the coastline evolution using photographs (1991) and satellite images treated by Remote Sensing and GIS tools. Extracted coastlines (schematized by polylines or extracted by the calculation of MNDWI index) have been superimposed. Their evolution (distances and rates) was calculated automatically using the Arc GIS Digital Shoreline Analysis System extension. Results show accelerated erosion over the last period 2016–2020 for all cells on the Island. The evolution over a period of 45 years, from 1975 to 2020, shows a coastline retreat along the entire Island (3 to 10 m/year), with the exception of the sandy spits of Ras Rmal and Borj Kastel (accretion due to the contributions of sediments by coastal drift currents). The sea level rise and the various hydrodynamic and anthropogenic forcings have led to this state instability and this generalized erosion.
Prospective association between an obesogenic dietary pattern in early adolescence and metabolomics derived and traditional cardiometabolic risk scores in adolescents and young adults from the ALSPAC cohort
Authors: Solsona Eduard Martínez , Johnson Laura , Northstone Kate , Buckland Genevieve 
Published: January 2023

AbstractBackground Dietary intake during early life may be a modifying factor for cardiometabolic risk (CMR). Metabolomic profiling may enable more precise identification of CMR in adolescence than traditional CMR scores. We aim to assess and compare the prospective associations between an obesogenic dietary pattern (DP) score at age 13 years with a novel vs. traditional CMR score in adolescence and young adulthood in the Avon Longitudinal Study of Parents and Children (ALSPAC). Methods Study participants were ALSPAC children with diet diary data at age 13. The obesogenic DP z-score, characterized by high energy-density, high % of energy from total fat and free sugars, and low in fibre density, was previously derived using reduced rank regression. CMR scores were calculated by combining novel metabolites or traditional risk factors (fat mass index, insulin resistance, mean arterial blood pressure, triacylglycerol, HDL and LDL cholesterol) at age 15 (n = 1808), 17 (n = 1629), and 24 years (n = 1760). Multivariable linear regression models estimated associations of DP z-score with log-transformed CMR z-scores. Results Compared to the lowest tertile, the highest DP z-score tertile at age 13 was associated with an increase in the metabolomics CMR z-score at age 15 (β = 0.20, 95% CI 0.09, 0.32, p trend < 0.001) and at age 17 (β = 0.22, 95% CI 0.10, 0.34, p trend < 0.001), and with the traditional CMR z-score at age 15 (β = 0.15, 95% CI 0.05, 0.24, p trend 0.020). No evidence of an association was found at age 17 for the traditional CMR z-score (β = 0.07, 95% CI -0.03, 0.16, p trend 0.137) and for both scores at age 24. Conclusions An obesogenic DP was associated with greater CMR in adolescents. Stronger associations were observed with a novel metabolite CMR score compared to traditional risk factors. There may be benefits from modifying diet during adolescence for CMR health, which should be prioritized for further research in trials.