bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prolonged SARS-CoV-2 infection successfully treated with a consecutive combined scheme therapy in an HIV- positive patient with AIDS
Authors: Vergori Alessandra , Baldini Francesco , Pinnetti Carmela , Grisetti Susanna , Mondi Annalisa , Matusali Giulia , Camici Marta , Maggi Fabrizio , Antinori Andrea 
Published: February 2023

Abstract
Purpose
Cases of persistent infection have already been widely described with some proposals for combination or extended course therapies in immunocompromised subjects, but nothing has been addressed in AIDS patients. We present a case of prolonged, mild SARS-CoV-2 infection that was successfully treated with a consecutive combined scheme of therapy.
Methods/Results
A prolonged shedding of SARS-CoV-2 was observed up to 92 days and the COVID-19 clinical manifestation was mild without evidence of pneumonia and/or acute respiratory insufficiency. The infection was not cleared after the first treatment with remdesivir IV as early treatment (for 3 days) suggesting a limited effect on SARS-CoV-2 in an immunocompromised individual. Several weeks later, a second therapeutic attempt was made with tixagevimab/cilgavimab 300/300 IM but SARS-CoV-2 RNA was still detected for further 5 weeks. A third attempt with nirmatrelvir/ritonavir determined the definitive viral clearance of SARS-CoV-2 after 92 days since the first detection.
Conclusion
Our data indicate that certain immunocompromised individuals may shed infectious virus longer and need a tailored and valuable therapeutics approach. Additional data from clinical trials are required to support a feasible approach to managing this vulnerable group of patients.
Landslide susceptibility modeling derived from remote sensing, multi-criteria decision analysis, and GIS techniques: A case study in the Southeast Bohol Province, Philippines
Authors: Tubog Michael Vincent , Villahermosa Ryan Lester , Perong John Glenn 
Published: February 2023

Abstract
Several landslide hazard susceptibility mapping has been done in the Philippines for the past decade to augment the need for vulnerability assessment. Being a karst region, the southeast Bohol province is accustomed to frequent landslide occurrences, causing hazard risks in adjacent communities. These landslides are generally controlled by both extrinsic (e.g., road network, fault) and intrinsic (e.g., geomorphologic and geologic) factors. Field observation denotes several occurrences along steep slopes and stream banks. However, the challenges in updating the landslide hazard susceptibility maps arose from the scarcity of updated field information. With data access limitations, this study aims to generate accurate and precise landslide susceptibility models using remote sensing and statistical-based analysis processed in Geographic Information System (GIS). This study uses open-sourced medium-resolution satellite data and digital elevation models are utilized to generate the 8 landslide factor maps. These maps were analyzed through Analytical Hierarchy Process (AHP) and Fuzzy Logic Overlay. The generated landslide susceptibility models were validated using Forest-based Classification and Regression (FBCR), analysis of variance (ANOVA), and ordinary linear regression. The AHP-based model shows significant accuracy and compatibility with the actual susceptibility of the site since the p-value of the map is 0.031 in ANOVA, while the Fuzzy-based model cannot be considered accurate since it generated a 0.266 p-value result. Moreover, both models were analyzed in FBCR and resulted in a p-value of 2.2x10-16 in the ordinary linear regression validation, making both significant landslide prediction models. This result denotes that medium-resolution satellite data can generate accurate and compatible landslide susceptibility and prediction models, and this process will give disaster risk reduction managers an avenue to generate landslide models that are not bounded by data access limitations.
Advancement in UV-Visible-IR Camouflage Textiles for Concealment of Defense Surveillance against Multidimensional Combat Backgrounds
Authors: Hossain Md. Anowar 
Published: February 2023

Abstract
Target detection of defense technology is being rapidly upgraded with modern surveillance technologies. The latest techniques of surveillance are already being implemented for defense applications. Self-protection and hiding from opposing forces are the key principle for protection of special team in defense. Camouflage textiles aims to create confusing objects for target detection of military personnel. These textiles are applied for military protection such as clothing, weapon, vehicle and location hiding nets/tents, etc. The urgent need of camouflage textiles have been formulated with a technical solution and implementation of right camouflage materials for concealment of defense target signature against dry leaves, green leaves, tree bark-woodland combat background; water-marine combat background; sand-desertland combat background; stone-stoneland combat background; snow-snowland combat background; sky combat background and ice-iceland combat background, concrete-concreteland combat background (DGTWSICB) in ultraviolet-visible-infrared (UV-Vis-IR) spectrums. This hypothesis of optical & surveillance engineering has been coalesced for advancement of UV-Vis-IR-DGTWSICB camouflage textiles technology. The principle of camouflage engineering has been approached by broader spectrum probe in UV-Vis-IR rather than Vis ranges only. Furthermore, single formulation of camouflage textiles has been proposed for multidimensional CBs-DGTWSICB. Electromagnetic spectrum, reflection, electron energy, photonic signal and imaging mechanism in UV-Vis-IR have been presented for optical engineering of concealment, detection, recognition and identification of target signature against DGTWSICB. Spectrum relationship of camouflage materials and DGTWSICB materials have been illustrated and compared in UV-Vis-IR spectrums. Camouflage material design, method design & spectral design; adaptive camouflage; techniques for camouflage textile assessment for digital camera and hyperspectral camera imaging; image processing techniques and a hierarchical model have been demonstrated for augmentation of camouflage textiles in UV-Vis-IR illumination. Therefore, anticipated design of camouflage textiles may enhance high-performance innovation for modern surveillance of military protection related to digital camera, hyperspectral camera and radar. This hypothesis includes advance guideline for camouflage textiles design for CBs-DGTWSICB.
Causal Associations of Sleep Traits with Cancer Incidence and Mortality
Authors: Tian Shan-Shan , Huangfu Longtao , Bao Yanping , Ai Si-Zhi , Chang Suhua , Wang Qianwen , Zhu Ximei , Yan Wei , Shi Le , Deng Jia-Hui , Lu Lin 
Published: February 2023

Abstract
Inconsistent results regarding the relationship between sleep traits and cancer incidence and mortality exist. Using data from UK Biobank participants, we conducted multivariable Cox regression, linear and non-linear Mendelian randomization (MR), and survival curve analyses to simultaneously assess the independent impact of chronotype, sleep duration, and insomnia symptoms on pan-cancer risk and mortality, including all-cause mortality, 5-year cancer mortality, and cancer mortality among cancer patients. A definite evening chronotype, long sleep duration, and frequent insomnia symptoms were associated with higher pan-cancer risk and mortality among cancer patients and potential causal risk factors of mortality in patients with cancer. Long sleep duration also had a causal relationship with pan-cancer incidence. In addition, the current study showed that the genetically predicted morning chronotype was associated with a reduction in pan-cancer risk and mortality among patients with cancer. These results suggest that some sleep traits, such as longer sleep duration, evening chronotype, and insomnia, play individual and joint roles in pan-cancer risk and mortality among cancer patients, which could be beneficial from the morning chronotype. Our findings highlight the importance of sleep management in cancer prevention and prognosis.
Fishery resource management with migratory prey harvesting in two zones- Delay and Stochastic approach
Authors: Niranjan H , Srin M.N. , Murty A.V.S.N. , Viswanathan K.K. 
Published: February 2023

Abstract
In this work, we looked at a two-zone aquatic habitat where both prey and predators can access the zones. The prey alternates between two zones at random. The growth of prey in the absence of a predator is believed to be logistic in each zone. The inner steady state is determined. Around the interior steady state, the deterministic model's local and global stability is investigated. Furthermore, a stochastic stability study is performed in the neighbourhood of a positive steady state, using analytical estimates of population mean square fluctuations to investigate the system's dynamics in the presence of Gaussian white noise.
Extracellular vesicle-Serpine-1 affects neural progenitor cell mitochondrial functions and synaptic density: modulation by amyloid beta and HIV-1
Authors: András Ibolya E. , Serrano Nelson , Djuraskovic Irina , Fattakhov Nikolai , Sun Enze , Toborek Michal 
Published: February 2023

Abstract
Brain endothelial extracellular vesicles carrying amyloid beta (EV-Aβ) can be transferred to neural progenitor cells (NPCs) leading to NPC dysfunction. However, the events involved in this EV-mediated Aβ pathology are unclear. EV-proteomics studies identified Serpine-1 (plasminogen activator inhibitor 1, PAI-1) as a major connecting “hub” on several protein-protein interaction maps. Serpine-1 was described as a key player in Aβ pathology and was linked to HIV-1 infection as well. Therefore, the aim of this work was to address the hypothesis that Serpine-1 can be transferred via EVs from brain endothelial cells to NPCs and contribute to NPC dysfunction. HBMEC concentrated and released Serpine-1 via EVs, the effect that was potentiated by HIV-1 and Aβ. EVs loaded with Serpine-1 were readily taken up by NPCs, and HIV-1 enhanced this event. Interestingly, a highly specific Serpine-1 inhibitor PAI039 increased EV-Aβ transfer to NPCs in the presence of HIV-1. PAI039 also partially blocked mitochondrial network morphology and mitochondrial function alterations in the recipient NPCs, which developed mainly after HIV + Aβ-EV transfer. PAI039 partly attenuated HIV-EV-mediated decreased synaptic protein levels in NPCs, while increased synaptic protein levels in NPC projections. These findings contribute to a better understanding of the complex mechanisms underlying EV-Serpine-1 related Aβ pathology in the context of HIV infection. They are relevant to HIV-1 associated neurocognitive disorders (HAND) in an effort to elucidate the mechanisms of neuropathology in HIV infection.
Association of maternal depression and hypothyroidism with infant gastroschisis: A population-based cohort study in Canada
Authors: Liu Shiliang , Hughes Claude , Yong Shin Jie , Chen Dunjin 
Published: February 2023

Abstract
Gastroschisis has increased globally over recent decades, and this increase has not been explained by identified risk factors. We conducted a population-based study of infants born in Canada, 2004–2020. We used “winter” months (i.e., September through June) and northern areas of residence as indicators of less sunlight/less active lifestyle, while “summer” (i.e., July and August) and southern areas were considered as reference. Rate of gastroschisis for infants conceived in winter (3.4 per 10 000) was higher than for infants conceived in summer (2.2 per 10 000; p < 0.001). Exposure to winter, and northern area hypothyroidism, substance or tobacco uses and depressive disorder were initially identified as risk factors for gastroschisis. There was a significant interaction between women < 24 years of age and 2-month conception intervals (rate ratio (RR): 1.42 (95% confidence interval [CI] 1.19–1.70). The association of maternal depression (mean ratio 2.19, 95% CI 0.87–3.50, p = 0.001) with infant gastroschisis was mediated by hypothyroidism (mean ratio 1.04, 95%CI 1.01–1.07, p < 0.001), whereas substance use, hypothyroidism, tobacco smoking and gestational diabetes showed 5.5-, 3.1-, 2.7, and 1.2-fold associations, respectively, with maternal depression. In contrast to the summer conception interval of low gastroschisis risk, an elevated risk of gastroschisis spans the other ten months in association with higher levels of stress adaptation, thermoregulation and metabolism, reproduction, and growth effector hormones. Our findings suggest that periconception depression may play a causal role in offspring gastroschisis.
Effects of Soft and Hard Fillers on Electromechanical Properties and Performance of Polydimethylsiloxane Elastomer for Actuator Applications
Authors: Prabhakar Om Prakash , Sahu Raj Kumar 
Published: February 2023

Abstract
Desired ratio of high relative permittivity and low elastic modulus limits the application of silicon rubbers in various engineering fields as flexible electromechanical actuators. The relative permittivity can be improved by incorporating varieties of high-k particles and polymer reagents as plasticizers and crosslinkers into elastomer matrix. The present work investigates the effect of polyethylene glycol flakes (PEG as plasticizer) and titanium boride (TB) particles (high-k particle) as soft and hard fillers respectively, on electromechanical (EM) properties of polydimethylsiloxane (PDMS) elastomer composite for soft actuators. Elastomer composites filled with various concentrations of fillers are created and labeled accordingly to distinguish impact of fillers on EM properties. Uniform dispersion for fillers is confirmed by FESEM, EDX, FTIR, and UV-Vis. Elastic modulus and relative permittivity are significantly influenced by filler contents for both fillers. Elastic modulus for lower concentrations (2 and 5 wt.%) of soft fillers (PEG) increases while 8 wt.% leads to as comparable to the base material (PDMS). Soft fillers (PEG) aid in maintaining low elastic modulus, whereas hard fillers (TB) increase electrical breakdown strength as well as dielectric loss with almost identical changes in relative permittivity for both composites. The maximum actuation strain of 30.8% and 26.2% is attained for an in-house fabricated linear actuator with 8 wt.% of PEG and TB particles, respectively. Methodology and results may be helpful in selection of fillers to improve the dielectric behavior of silicon elastomers depending on the acceptable range of their adverse effect on other properties.
The Way Ahead for the IPCC &amp; Policymakers after the Sixth Assessment Report &amp; COP27
Authors: Barker Terry 
Published: February 2023

Abstract
“... transformative action to achieve climate resilient development ... will help to break the mindset that for decades has kept us from moving beyond business as usual. ...The decisions taken here today reemphasize the critical importance of empowering all stakeholders to engage in climate action. ...” COP27 Closing Remarks by the UN Climate Change Executive Secretary, 20 November 2022
“We should see where & when to go forwards by looking backwards to see how & why we came to be where we are.”
Martin Weitzman aptly called climate policy “a wicked ‘problem from hell’ for the following reasons: (1) the large-scale risks (non-linear), huge uncertainty and irreversibility; (2) the global and intergenerational dimensions (justice); and (3) its character of a global common-pool resource problem” (quoted in Kowarsch 2016 p. 33). Climate change with air pollution is a large-scale complex problem such that nearly all nations must be involved in its solution.
The IPCC has been set up to provide scientific evidence and advice to governments. It aims to be apolitical and policy neutral as the international equivalent of national committees, chaired by Chief Scientists. It provides the scientific evidence on climate change and covers the literature on the appropriate response strategies and their global and national consequences.
Looking back, the IPCC has evolved as an institution in response to policymakers’ expressed needs, i.e. leaders, who now are urgently calling for solutions. And, of course, the accumulating evidence of climate change and its dangerous effects. Looking forward, the IPCC faces a turning point: either it continues as before, with 7-year gaps between Assessment Reports, or switches to a timelier framework, dictated by the urgency of the problem. This paper considers both the past evolution of the IPCC and proposes radical changes in approach both in the timeliness of reports and in the coverage of the climate scenarios to include those made by governmental bodies.
Factors associated with non-invasive positive pressure ventilation failure in a COVID-19 Intermediate Care Unit
Authors: Farinha Inês , Cunha Alexandra Tenda da , Nogueira Ana Rita , Ribeiro André , Silva Carlos , Rua João , Trêpa João , Mateus José Eduardo , Costa Filipa 
Published: February 2023

Abstract
Background:
The use of non-invasive positive pressure ventilation (NIPPV) in COVID-19 patients with hypoxaemia is still under debate. The aim was to evaluate the efficacy of NIPPV (CPAP, HELMET-CPAP or NIV) in COVID-19 patients treated in the dedicated COVID-19 Intermediate Care Unit of Coimbra Hospital and University Centre, Portugal, and to assess factors associated with NIPPV failure. Patients admitted from December 1st 2020 to February 28th 2021, treated with NIPPV due to COVID-19 were included. Failure was defined as orotracheal intubation (OTI) or death during hospital stay. Factors associated with NIPPV failure were included in a univariate binary logistic regression analysis; those with a significance level of p < 0.001 entered a multivariate logistic regression model.
Results:
A total of 163 patients were included, 64.4% were males (n = 105). The median age was 66 years (IQR 56–75). NIPPV failure was observed in 66 (40.5%) patients, 26 (39.4%) were intubated and 40 (60.6%) died during hospital stay. Highest CRP (OR 1.164; 95%CI 1.036–1.308) and morphine use (OR 24.771; 95%CI 1.809-339.241) were identified as predictors of failure after applying multivariate logistic regression. Adherence to prone positioning (OR 0.109; 95%CI 0.017-0.700) and a higher value of the lowest platelet count during hospital stay (OR 0.977; 95%CI 0.960–0.994) were associated with a favourable outcome.
Conclusions:
NIPPV was successful in 59.5% of patients. Highest CRP during hospital stay and morphine use were predictors of failure. Adherence to prone positioning and a higher value of the lowest platelet count during hospital stay were associated with a favourable outcome.
Kombucha electronics
Authors: Adamatzky Andrew , Tarabella Giuseppe , Phillips Neil , Chiolerio Alessandro , D’Angelo Passquale , Nicolaidou Anna , Sirakoulis Georgios Ch. 
Published: February 2023

Abstract
A kombucha is a tea and sugar fermented by over sixty kinds of yeasts and bacteria. This symbiotic community produces kombucha mats, which are cellulose-based hydrogels. The kombucha mats can be used as an alternative to animal leather in industry and fashion once they have been dried and cured. Prior to this study, we demonstrated that living kombucha mats display dynamic electrical activity and distinct stimulating responses. For use in organic textiles, cured mats of kombucha are inert. To make kombucha wearables functional, it is necessary to incorporate electrical circuits. We demonstrate that creating electrical conductors on kombucha mats is possible. After repeated bending and stretching, the circuits maintain their functionality. In addition, the abilities and electronic properties of the proposed kombucha, such as being lighter, less expensive, and more flexible than conventional electronic systems, pave the way for their use in a diverse range of applications.
Major dietary patterns and dietary inflammatory index in relation to dyslipidemia; RaNCD Cohort Study
Authors: Pasdar Yahya , Moradi Fardin , Sedighi Mohammad , Saber Amir , Moradi Shima , Bonyani Mitra , Najafi Farid 
Published: February 2023

Abstract
Dyslipidemia can increase risk of heart attack and stroke because blood can’t flow through your arteries easily. Dietary modification is an appropriate approach to reducing this phenomenon. This cross-sectional study was aimed to evaluate major dietary patterns and dietary inflammatory index (DII) in relation to dyslipidemia. 5954 participants of Ravansar non- communicable diseases (RaNCD) cohort study were eligible for this study. Dyslipidemia was diagnosed based on the lipid profile under consideration of RaNCD physician. Dietary patterns were assessed by principal component analysis. The three identified dietary patterns included: 1) plant- based diet; 2) high protein and sugar diet; and 3) energy dense diet. DII also was calculated based on the dietary information. We found that higher adherence to DII was significantly increased odds of dyslipidemia after adjusted for age, sex, and physical activity (OR: 1.24; CI 95%: 1.09–1.42). Additionally, higher adherence to high protein and sugar diet and energy dense diet were significantly associated with higher odds for dyslipidemia (OR: 1.31; CI 95%: 1.16–1.49) and (OR: 1.28; CI 95%: 1.12–1.46). Nevertheless, following to plant based diet had no association with dyslipidemia. We did not any association even adjusted for the mentioned potential confounders. Our results highlighted that greater following to DII, high protein and sugar diet and energy dense diet can undesirable effects on dyslipidemia.