bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation Of Iron Overload Approach in Thalassemia Patients at The Thalassemia Center
Authors: alchujaa Mohamad nahel , halim Haya abdul , sulaiman Seham 
Published: March 2023

Abstract
Background: Thalassemia is a genetic blood disorder as a result of a defect in the genes responsible for the production of globin chains in hemoglobin, which is responsible for transporting oxygen to the cells of the body. Iron buildup is common in thalassemia patients as a result of frequent blood transfusions or because of the disease itself. The objectives of this research depend on the approach of iron overload in thalassemia patients, its causes and the resulting complications.
Methods: A cross-sectional study was conducted in July 2022 by collecting data for thalassemia patients at the Damascus University Center, and work was done to convert this information into statistical tables and graphs in order to obtain the required objectives of this research.
Results: By studying and comparing the serum ferritin values and following up the iron chelates used in thalassemia patients, these inferential statistics were reached: An increase in serum ferritin values in 70.6% of thalassemia patients while taking iron chelates. After discussing the reasons with the Thalassemia Center doctors supervising these cases, it was concluded that the reasons for the increase are due to: Non-compliance and lack of commitment with iron chelates as a result of its side effects such as nausea or vomiting, flatulence and abdominal pain, constipation or diarrhea, Material costs, Neglecting to take medication (either disregard for medical importance or as a result of being busy with work).We note from the cases of the 29.4% of patients whose ferritin values decreased that: 50% of cases were treated with the combination of deferiprone with another drug, and this indicates its effectiveness more than others.
gym-flp: A Python Package for Training Reinforcement Learning Algorithms on Facility Layout Problems
Authors: Heinbach Benjamin Thomas , Burggräf Peter , Wagner Johannes 
Published: March 2023

Abstract
Reinforcement learning (RL) algorithms have proven to be useful tools for combinatorial optimisation. However, they are still underrepresented in facility layout problems (FLPs). At the same time, RL research relies on standardised benchmarks such as the Arcade Learning Environment. To address these issues, we present an open-source Python package (gym-flp) that utilises the OpenAI Gym toolkit, specifically designed for developing and comparing RL algorithms. The package offers one discrete and three continuous problem representation environments with customisable state and action spaces. In addition, the package supports 138 discrete and 61 continuous problems commonly used in FLP literature. The user can choose between numerical and visual output of observations, depending on the RL approach being used. The package aims to facilitate experimentation with different algorithms in a reproducible manner and advance RL use in factory planning.
Influence of large-scale teleconnections on annual and seasonal floods in Godavari and Narmada River basins
Authors: Gurrapu Sunil , Ranade Ashwini , Patra Jagadish Prasad 
Published: March 2023

AbstractIndian summer monsoon rainfall is strongly influenced by large-scale atmosphere-ocean oscillations including Pacific Decadal Oscillation (PDO), El Niño-Southern Oscillation (ENSO), and Indian Ocean Dipole (IOD). Researchers have shown that the negative phase of PDO or La Niña episodes of ENSO produce higher magnitude rainfall and hence relatively wetter years. So, it is imperative to have better knowledge of flood characteristics in the Indian watersheds for optimal planning and design of various infrastructure, and for optimal planning and management of reservoir operations. Traditionally, such information is estimated using flood frequency analysis (FFA), however the adequacy of traditionally accepted assumption that the annual peak flows are independent and identically distributed (i.i.d.) is questioned globally. This study evaluates the adequacy of this assumption in Godavari and Narmada River basins and assesses the influence of PDO, ENSO and IOD on flood characteristics. The results indicate that the flood characteristics at the majority of gauges are significantly influenced by these oscillations, higher magnitude floods are associated with negative episodes. A very few gauges are inversely related to these teleconnections, although statistically not significant. Overall, the signal of all the three teleconnections is found in the annual and seasonal floods in the majority of gauging stations.
Amoxicillin Induced Fever, Rash, and Catatonia - A Case Study
Authors: Yadav Chunnu Kumar , Ranka Rajat , Panda Prasan Kumar , Shah Bishal Pratap , Mishra Mayank Kumar , Krishnan Vijay 
Published: March 2023

Introduction:
Adverse drug reactions (ADR) are defined as any harmful or unpleasant
events or injuries resulting from the use of any particular drug. Among those antibiotics that cause
adverse reactions, amoxicillin is one of them. Catatonia and vasculitic rash are its rare adverse
effects.

Case Presentation:
A 23-year-old postpartum female, with a history of taking empirical Amoxiclav
(amoxicillin-clavulanic acid 625 mg) injection and oral tablets for episiotomy wound, presented
with altered sensorium and fever followed by maculopapular rash. On examination, she had
generalized rigidity with waxy flexibility that improved by lorazepam challenge and was diagnosed
as catatonia. On evaluation, amoxicillin was found to be precipitating catatonia in this patient.

Conclusion:
Since the diagnosis of catatonia is often missed, any cases with clinical presentation
of fever, rash, altered sensorium, and generalized rigidity should also be suspected for druginduced
ADR and the precipitating factor should be searched for.
Development and In-vitro Evaluation of Dexamethasone Enriched Nanoemulsion for Ophthalmic Indication
Authors: Jadhav Ajinkya , Salave Sagar , Rana Dhwani , Benival Derajram 
Published: March 2023

Background:
Dexamethasone (DEX) is a glucocorticosteroid used in the treatment of steroid-responsive inflammatory conditions of the eye. The currently marketed formulations pose several issues, like poor drug residence time, resulting in frequent administration of the formulation, making them less effective.

Objective:
The present study aims to provide comprehensive data encompassing the designing, op-timization, development, and characterization of DEX nanoemulsion (DEX NE) for treating in-flammatory conditions of the anterior segment of the eye by employing the Quality by Design (QbD) approach.

Methods:
A Plackett-Burman Design (PBD) was employed to screen seven independent variables, such as oil concentration, surfactant concentration, polymer concentration, homogenization speed and time, microfluidization pressure and cycles, and their influence on critical quality attributes (CQAs), such as globule size, zeta potential, and viscosity, was evaluated. Furthermore, the Box-Behnken design (BBD) was employed for optimization, and design space was generated to obtain the optimized DEX NE.

Results:
The experimental results after DEX NE characterization reveal a globule size of 181 ± 90 nm with a zeta potential of -21.03 ± 1.68 mV and a viscosity of 19.99 cp. Furthermore, the drug re-lease study of simulated tear fluid demonstrated prolonged and steady release for up to 48 hr. Cyto-toxicity assay of DEX NE exhibited good cell viability.

Conclusion:
All these findings pave the way for a better understanding of developing a robust, safe, and non-toxic formulation for ocular drug delivery.
Odevixibat: A Review of a Bioactive Compound for the Treatment of
Pruritus Approved by the FDA
Authors: Porwal Mayur , Kumar Arvind , Rastogi Vaibhav , Maheshwari Kamal Kishore , Verma Anurag 
Published: March 2023

Abstract:
Odevixibat is synthesized through chemical modification of Benzothiazepine's structure.
It is a tiny chemical that inhibits the ileal bile acid transporter and is used to treat a variety of
cholestatic illnesses, including progressive familial intrahepatic cholestasis (PFIC). For cholestatic
pruritus and liver disease development, bile acid transporter inhibition is a unique treatment strategy.
Odevixibat reduces enteric bile acid reuptake. Oral odevixibat was also studied in children
with cholestatic liver disease. Odevixibat received its first approval in the European Union (EU) in
July 2021 for the treatment of PFIC in patients aged 6 months, followed by approval in the USA
in August 2021 for the treatment of pruritus in PFIC patients aged 3 months. Bile acids in the distal
ileum can be reabsorbed by the ileal sodium/bile acid cotransporter, a transport glycoprotein.
Odevixibat is a sodium/bile acid co-transporter reversible inhibitor. An average 3 mg once-daily
dose of odevixibat for a week resulted in a 56% reduction in the area under the curve of bile acid.
A daily dose of 1.5 mg resulted in a 43% decrease in the area under the curve for bile
id. Odevixibat is also being evaluated in many countries for the treatment of other cholestatic illnesses,
including Alagille syndrome and biliary atresia. This article reviews the updated information
on odevixibat with respect to its clinical pharmacology, mechanism of action, pharmacokinetics,
pharmacodynamics, metabolism, drug-drug interactions, pre-clinical studies, and clinical
trials.
Design and Statistical Optimization of Novel Polyelectrolyte Complex Microbeads
to Improve Entrapment Efficiency and Release Study of Vildagliptin
Authors: Tiwari Ritesh Kumar , Singh Lalit , Singh Mukesh Kr. 
Published: March 2023

Background:
The current research focused on the improvement of drug entrapment efficiency
and release study of hydrophilic drug through polymer complextation.

Objective:
Ionotropic gelation technique was utilised for the preparation of Polyelectrolyte complex
microbeads of Vildagliptin using Sodium alginate and Eudragit RL100 and their performance was optimized
by Central composite design.

Methods:
Fourier Transform Infrared Spectroscopy, Scanning Electron Microscope, Differential
Scanning Calorimetry, particle size, Drug Entrapment Efficiency, X-ray diffraction and in vitro drug
release at 10hr were chosen for evaluating formulated microbeads. The impact of independent variables
like concentration of sodium alginate and eudragit RL100 was examined over dependent responses.

Results:
The interpretation of XRD, SEM, DSC, and FTIR affirmed no drug excipients interference
and confirmed formation of polyelectrolyte complex microbeads. For complex microbeads, the maximum
and minimum drug release after 10 hours was obtained as 96.23.5% and 89.45%, respectively.
The 32 central composite design was further used to obtain response surface graph and the values for
the particle size, DEE and Drug release were retained as 0.197, 76.30 % and 92.15%, respectively for
the optimize batch.

Conclusion:
The result suggested the combination of two polymers (Sodium alginate and Eudragit
RL100) were suitable for improving the entrapment efficiency of hydrophilic drug (Vildagliptin). The
central composite design (CCD) technique is an effective tool for obtaining optimal drug delivery systems
of Vildagliptin polyelectrolyte complex microbeads.
Willingness to Vaccinate Against Herpes Zoster and Its Associated Factors Across WHO Regions: Global Systematic Review and Meta-Analysis
Authors: Wang Qiang , Yang Liuqing , Li Lan , Liu Chang , Jin Hui , Lin Leesa 
Published: March 2023

Background
A life-course immunization approach would enhance the quality of life across all age groups and improve societal well-being. The herpes zoster (HZ) vaccine is highly recommended for older adults to prevent HZ infection and related complications. The proportions of willingness to receive the HZ vaccine varies across countries, and various kinds of factors, including sociodemographics and individual perceptions, influence the willingness to vaccinate.

Objective
We aim to estimate the HZ vaccination willingness rate and identify factors associated with vaccine uptake willingness across all World Health Organization (WHO) regions.

Methods
A global systematic search was performed on PubMed, Web of Science, and the Cochrane Library for all papers related to the HZ vaccine published until June 20, 2022. Study characteristics were extracted for each included study. Using double arcsine transformation, vaccination willingness rates with 95% CIs were pooled and reported. The willingness rate and associated factors were analyzed by geographical context. Associated factors were also summarized based on Health Belief Model (HBM) constructs.

Results
Of the 26,942 identified records, 13 (0.05%) papers were included, covering 14,066 individuals from 8 countries in 4 WHO regions (Eastern Mediterranean Region, European Region, Region of the Americas, and Western Pacific Region). The pooled vaccination willingness rate was 55.74% (95% CI 40.85%-70.13%). Of adults aged ≥50 years, 56.06% were willing to receive the HZ vaccine. After receiving health care workers’ (HCWs) recommendations, 75.19% of individuals were willing to get the HZ vaccine; without HCWs’ recommendations, the willingness rate was only 49.39%. The willingness rate was more than 70% in the Eastern Mediterranean Region and approximately 55% in the Western Pacific Region. The willingness rate was the highest in the United Arab Emirates and the lowest in China and the United Kingdom. The perception of HZ severity and susceptibility was positively associated with vaccination willingness. The perceived barriers to vaccination willingness (main reasons for unwillingness) included low trust in the effectiveness of the HZ vaccine, concerns about safety, financial concerns, and being unaware of the HZ vaccine’s availability. Older individuals, those having lower education, or those having lower income levels were less likely to willing to be vaccinated.

Conclusions
Only 1 in 2 individuals showed a willingness to be vaccinated against HZ. The willingness rate was the highest in the Eastern Mediterranean Region. Our findings show the critical role HCWs play in promoting HZ vaccination. Monitoring HZ vaccination willingness is necessary to inform public health decision-making. These findings provide critical insights for designing future life-course immunization programs.
Prosedur Penanganan Keluhan Tamu di Kepitu Restaurant The Kayon Resort
Authors: Widelia Dewa Ayu Asri 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui proses pembuatan cuka sari buah sirsak yang kemudian di aplikasikan sebagai pengganti white vinegar dalam pembuatan hollandaise sauce dan untuk mengetahui kualitas dari hollandaise sauce dengan cuka sari buah sirsak dari segi warna, rasa, tekstur, aroma, dan penampilan serta dapat mengetahui anggaran biaya produksi pada pembuatan cuka sari buah sirsak, minat pembeli, dan pengemasannya. Penelitian yang diterapkan dalam penelitian ini adalah jenis penelitian eksperimental dengan menggunakan rancangan percobaan lengkap (RAL). Hasil penelitian yang sudah dilakukan dengan dua buah produk hollandaise sauce , P1 yaitu hollandaise sauce dengan cuka sari buah sirsak dan P2 yaitu hollandaise sauce tanpa cuka sari buah sirsak sebagai pembanding, dengan menggunakan uji organoleptik (hedonik) dengan analisis data menggunakan observasi, wawancara, dan kuisioner. Berdasarkan hasil penelitian melalui 16 panelis yang menguji kualitas hollandaise sauce cuka sari buah sirsak, memilki kualitas yang baik, sehingga dapat ditarik kesimpulan bahwa P1 dapat menggantikan P2 atau sebaliknya karena tidak berpengaruh terhadap uji warna, aroma,tekstur, rasa dan penampilan.

Handling guest complaints is useful as a guide in the future so that the same complaint does not occur, to improve the quality of services or products in the restaurant, to know the assessment and wishes of guests, to determine weaknesses or standard deviations, to know employee performance. This study uses a qualitative descriptive approach, which explains the factors that cause guest complaints, and procedures for handling guest complaints. According to this study, it was found that there were several complaints that guests complained that the order service was too long, the order was not in accordance with the guest's request, the taste of the menu was not standard, the waiter's lack of accuracy. The handling of guest complaints is good, but there are still some waiters who have not carried out operational procedures such as no waiters who record complaints, some waiters do not report to superiors, some waiters do not record complaints in the log book. Where the procedure with reality is not fully appropriate. The advice given is to hold training to foster an attitude of responsibility and care, and follow the SOPs that have been set, if the staff violates the SOPs, they are subject to sanctions.
A model integrating satellite-derived shoreline observations for predicting fine-scale shoreline response to waves and sea-level rise across large coastal regions
Authors: Vitousek Sean , Vos Kilian , Splinter Kristen D , Erikson Li , Barnard Patrick L 
Published: March 2023

Satellite-derived shoreline observations combined with dynamic shoreline
models enable fine-scale predictions of coastal change across large
spatiotemporal scales. Here, we present a satellite-data-assimilated,
“littoral-cell”-based, ensemble Kalman-filter shoreline model to
predict coastal change and uncertainty due to waves, sea-level rise, and
other natural and anthropogenic processes. We apply the developed
ensemble model to the entire California coastline (approximately 1,350
km), much of which is sparsely monitored with traditional survey methods
(e.g., Lidar/GPS). Water-level-corrected, satellite-derived shoreline
observations (obtained from the CoastSat toolbox) offer a nearly
unbiased representation of in-situ surveyed shorelines (e.g., Mean Sea
Level elevation contours) at Ocean Beach, San Francisco. We demonstrate
that model calibration with satellite observations during a 20-year
hindcast period (1995 to 2015) provides a nearly equivalent model
forecast accuracy during a validation period (2015 to 2020) compared to
model calibration with monthly in-situ observations at Ocean Beach. When
comparing model-predicted shoreline positions to satellite-derived
observations, the model achieves an accuracy of <10 m RMSE for
nearly half of the entire California coastline for the validation
period. The calibrated/validated model is then applied for multi-decadal
simulations of shoreline change due projected wave and sea-level
conditions while holding the model parameters fixed. By 2100, the model
estimates that 25 to 70% of California’s beaches may become completely
eroded due to sea-level rise scenarios of 0.5 to 3.0 m, respectively.
The satellite-data-assimilated modeling system presented here is
generally applicable to a variety of coastal settings around the world
owing to the global coverage of satellite imagery.
PENGARUH PROFITABILITAS, LEVERAGE, DAN RISIKO SISTEMATIS TERHADAP NILAI PERUSAHAAN DENGAN IFR SEBAGAI VARIABEL INTERVENING
Authors: Muthi'ah Siti , Chang Iskandar 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui pengaruh profitabilitas, leverage, risiko sistematis terhadap nilai perusahaan dengan pelaporan keuangan internet sebagai variabel intervensi pada perusahaan yang terdaftar di JII 30 periode 2017-2021 dengan jumlah 8 sampel. Metode purposive sampling digunakan untuk menentukan sampel, dan teknis analisis menggunakan berganda. Hasil penelitian : (1) Berdasarkan hasil analisis yang diperoleh bahwa profitabilitas berpengaruh positif dan signifikan terhadap nilai perusahaan. (2) hasil Berdasarkan analisis diperoleh bahwa leverageberpengaruh negatif terhadap nilai perusahaan. (3) hasil Berdasarkan analisis diperoleh bahwa risiko sistematis tidak memiliki pengaruh signifikan terhadap perusahaan. (4) hasil Berdasarkan analisis Internet Financial Reporting tidak memiliki pengaruh signifikan terhadap nilai perusahaan. (5) hasil Berdasarkan analisis profitabilitas tidak memiliki pengaruh signifikan terhadap pelaporan keuangan internet. (6) hasil Berdasarkan analisis leverage tidak memiliki pengaruh signifikan terhadap pelaporan keuangan internet. (7) Berdasarkan hasil analisis risiko sistematis tidak memiliki pengaruh signifikan terhadap pelaporan keuangan internet. (8) Berdasarkan hasil analisispelaporan keuangan internet tidak dapat memediasi pengaruh profitabilitas terhadap nilai perusahaan. (9) Berdasarkan hasil analisis pelaporan keuangan internet tidak dapat memediasi pengaruh leverage terhadap nilai perusahaan. (10) Berdasarkan hasil analisis pelaporan keuangan internet tidak dapat memediasi pengaruh risiko sistematis terhadap nilai perusahaan.
Kata kunci: Profitabilitas, Leverage, Risiko Sistematis, Internet Financial Reporting dan Nilai Perusahaan
Towards an improved understanding of bark beetle and other insect herbivore infestation in conifer forests
Authors: Netherer Sigrid 
Published: March 2023

Summary
European forest ecosystems are increasingly exposed to stressors such as storm, drought episodes and mass attack of forest insect pests. Sustainable forest management requires a fundamental understanding of causal relationships between forest structures and the occurrence of disturbance events, as well as a well-functioning transfer of scientific knowledge into practice. Risk or predisposition assessment, phenological models or prediction of deficits in stand water supply can serve as decision support for prophylactic and protective measures in forestry. This overview addresses the theoretical approaches to insect pest-related mortality in forests that form the basis for such models. Many insect herbivore species benefit from increased temperatures and drought. For example, there is a clear correlation between bark beetle infestation and summer temperatures, storm damage and precipitation deficits. Drought stress is one of the main factors predisposing conifer forests to bark beetle infestation and significantly impacts interactions among Picea abies, Ips typographus and its associated ophiostomatoid fungi. A multi-year study focused on the effects of drought on the defence capacity and attractiveness of Norway spruce to I. typographus. The empirical dataset gained in field and laboratory experiments provides new insights into defence responses of this important tree species against biotic infestations under drought.