bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of Soluble Epoxide Hydrolase Confers Neuroprotection and Restores Microglial Homeostasis in a Tauopathy Mouse Model
Authors: Wang Shuo , Qi Chuangye , Rajpurohit Chetan , Ghosh Baijayanti , Xiong Wen , Wang Baiping , Qi Yanyan , Hwang Sun Hee , Hammock Bruce D. , Li Hongjie , Gan Li , Zheng Hui 
Published: February 2025

Abstract

Background: The epoxyeicosatrienoic acids (EETs) are derivatives of the arachidonic acid metabolism with anti-inflammatory activities. However, their efficacy is limited due to the rapid hydrolysis by the soluble epoxide hydrolase (sEH). Accordingly, inhibition of sEH has been shown to stabilize the EETs and dampen neuroinflammation in Ab mouse models of Alzheimer’s disease (AD). However, the role of the sEH-EET signaling pathway in other cell types of the CNS and in other neurodegenerative conditions are less understood.
Methods: Here we examined the mechanisms and the functional role of the sEH-EET axis in tauopathy by treating the PS19 mice with a small molecule sEH inhibitor TPPU and by crossing the PS19 mice with Ephx2 (gene encoding sEH) knockout mice, followed by single-nucleus RNA-sequencing (snRNA-seq), biochemical and immunohistochemical characterization, and behavioral analysis. We also tested the effect of the sEH-EET pathway in primary microglia cultures and human induced pluripotent stem cell (iPSC)-derived neurons that develop seeding-induced Tau inclusions.
Results: We show that sEH inhibition improved cognitive function, rescued neuronal cell loss, and reduced Tau pathology and microglia reactivity. snRNA-seq revealed that TPPU treatment resulted in the upregulation of actin cytoskeleton and excitatory synaptic pathway genes. Treating the human iPSC-derived neurons with TPPU led to enhanced synaptic density without affecting Tau accumulation, indicating a cell-autonomous effect of sEH blockade in neuroprotection. Further, sEH inhibition reversed disease-associated and interferon-response microglia states in PS19 mice and EET supplementation enhanced Tau phagocytosis and clearance in primary microglia cultures.
Conclusion: These findings demonstrate that sEH blockade or EET augmentation confer therapeutic benefit against neurodegenerative tauopathies through parallel targeting of neuronal and microglial pathways.
Rare Unicentric Intrapulmonary Castleman Disease: A Systematic Review and Report of a Case
Authors: Pannu Manjinder Kaur , Ehrsam Jonas Peter , Adamenko Olga Meier , Inci Ilhan , Schöb Othmar Markus 
Published: February 2025

Objectives
Castleman disease (CD) is a very rare B-cell lymphoproliferative disorder marked by the abnormal enlargement of lymph node tissue. It can present as either unicentric (UCD) or multicentric, with the former often appearing in intrathoracic regions, although its presence within the lungs is uncommon.

Methods
We report the case of a 42-year-old woman who underwent resection of an 11 cm intrapulmonary UCD. Additionally, we conducted a systematic review of the demographics, clinical presentation, diagnosis, and treatment approaches for intrapulmonary UCD.

Results
Our review identified 35 documented cases of intrapulmonary UCD, including our case. The average age was 34 years, with a female predominance of 57.7%. Tumor sizes ranged from 1.5 to 11 cm, with our case being the largest. Of the 24 cases with reported anamnesis, 58.3% were asymptomatic, while 41.7% had nonspecific symptoms such as cough, chest pain, or fever (as in our case). Histological analysis was available for 24 cases, with 83.3% identified as the hyaline vascular type. Biopsies through small needle aspiration or fresh-frozen samples failed in all attempts, requiring resection for diagnosis and treatment. Due to high vascularity, delicate location, and lack of diagnosis, lobectomy or pneumonectomy was performed in 45.7% of cases. Among the 11 cases with reported follow-up, no disease recurrence was observed over an average of 3 years.

Conclusion
Our systematic review highlights the rarity of UCD in the lungs. The demographics of intrapulmonary UCD align with the general disease profile. Surgical removal is crucial for both diagnosis and treatment. The significant vascularity and pulmonary location of these tumors present challenges, requiring pre-operative awareness and precautions.
“My Cry as an Orphaned Child Living in a Child-headed Household”: A Case of a Rural Community in a Bosheka Village, South Africa
Authors: Tshivhase Shonisani , Ntsieni Mashau , Diphofa Kabelo 
Published: February 2025

Background
Child-headed households are homes where parents or guardians are absent, and the children support each other, with the eldest child usually becoming the head of the household. The care of children within African societies often extends beyond just the parents. The extended family plays a crucial role in the upbringing and support of children. It is, therefore, assumed that the extended family and the community would take turns caring for orphaned children; however, sometimes, that is not the case.

Objective
This study aimed to explore the challenges faced by orphaned children living in child-headed households in a selected village in South Africa.

Methodology
The study adopted a qualitative approach using an exploratory phenomenological design. The sample size was comprised of 20 participants, which was determined by data saturation, and a thematic data analysis was performed on the collected data.

Results
Three themes emerged from the data: food insecurity, sexual abuse, and the responsibility of staying alone; hence, children who live in child-headed households face different psychological and socio-economic challenges.

Conclusion
The study found that child-headed families experience various challenges, such as psychosocial needs and lack of financial support. The study recommends that a longitudinal study should be conducted on these children to explore the impact of growing up without parental care on their adult lives.
Fuzzy models for assessing the level of adaptive potential of the central nervous system in engineering and technical personnel
Authors: Korenevsky N. A. , Safronov R. I. , Lukash O. Y. , Rodionova S. N. , Siplivy G. V. , Aksеnov V. V. 
Published: February 2025

The purpose of the research is to develop a method for assessing the level of adaptive potential of the central nervous system, which allows improving the quality of decisions made in the tasks of forecasting and diagnosing diseases characteristic of engineering and technical personnel.Methods. It is shown that the adaptive potential is a fuzzy variable described in the framework of the classical theory of fuzzy logic. Within the framework of this methodology, for the synthesis of decisive rules for assessing the level of adaptive potential of the central nervous system, normalizing functions of the level of adaptation are introduced for indicators selected from a set of test methods describing the state of the system under study, which are aggregated into the desired hybrid fuzzy model. Considering that engineering work is often accompanied by a high level of psychoemotional stress and mental fatigue, a device for monitoring the functions of attention and memory was chosen to assess the state of the central nervous system, which allows forming the volume of initial data necessary to solve the tasks.Results. In the course of the conducted research, to synthesize the decisive rules for assessing the level of adaptive potential of the central nervous system, taking into account the specifics of the work of engineering and technical workers, a set of informative signs was formed consisting of the level of personal and situational anxiety, concentration of attention and an indicator characterizing the state of RAM blocks, calculated by the method of determining the missing digit. For this set of indicators, the corresponding normalizing functions of the level of adaptation were obtained, the aggregation of which gives the desired fuzzy mathematical model for assessing the level of adaptive potential of the central nervous system.Conclusion. In the course of the conducted research, a method for assessing the level of adaptive potential of the central nervous system was developed and a corresponding fuzzy model for assessing the level of this potential was obtained, focusing on the peculiarities of the work of engineering and technical workers. During the expert assessment and mathematical modeling, it was shown that the confidence in the correct assessment of the level of adaptive potential of the central nervous system exceeds 0.9.
Models and algorithms for the formation of commanding influences of the control system of the rehabilitation exoskeleton two-link foot
Authors: Jatsun S. F. , Kislyak L. B. , Saveleva E. V. , Fursov G. А. 
Published: February 2025

The purpose of research is to develop a mathematical model of a two-link active foot of a rehabilitation exoskeleton for the lower extremities and to obtain data for generating the setting effects on the device drives.Methods. The article discusses a method for creating reference actions for the drive control system of a two-link foot of a rehabilitation exoskeleton. This device is designed for complex mechanical processing of the ankle joint in order to restore its mobility and bring movements closer to a natural gait. For this purpose, the video trajectory capture method is used in the framework of the experiment, which creates trajectories of movement of characteristic points of the foot taking into account the gait parameters and anthropometry of the patient. When processing the data, a 5th-order Fourier series is used, which allows approximating the obtained experimental trajectories with a given accuracy and ensuring their smoothness.Results. The work established that the mathematical model of a two-link foot allows analyzing and predicting the movement of the robot's foot in various rehabilitation modes. The model takes into account control and disturbance effects, as well as parameters such as mass, moment of inertia, step length, leg lift height, and other characteristics. The results of mathematical modeling allow synthesizing the robot's drive system - a set of mechanisms that transmit movement from the engine to the foot links. This will help ensure reliable and efficient operation of the device. In addition, the modeling results will be used to design the main structural elements of the robot, such as hinges, fasteners, shock absorbers, etc.Conclusion. The results of mathematical modeling allow us to calculate the robot's drive system - a set of mechanisms that transmit movement from the engine to the foot links. This will help ensure reliable and efficient operation of the device. In addition, the modeling results will be used to design the main structural elements of the robot, such as hinges, fasteners, shock absorbers, etc. This will allow us to create a durable and long-lasting device that can perform its functions in various operating conditions.
The use of EMG to assess the effectiveness and safety of an industrial exoskeleton in the workplace
Authors: Yatsun A. S. , Shcherbakova M. P. , Malchikov A. V. 
Published: February 2025

The purpose of research the work is to evaluate the effectiveness and safety of the use of an industrial exoskeleton using EMG in the conditions of modeling labor activity.Methods. Guided by GOST R 60.5.3.3-2023 and the national standard of the Russian Federation GOST R 60.5.2.1- 2023, a non-invasive technique for the general assessment of the human cardiorespiratory system, electromyography as a key way to assess the bioelectric activity of muscles, as well as conducting interviews with research participants were used.Results. The data obtained as a result of the study using the selected methods showed significant differences between the registered values of the indicators of volunteers who worked without PE and with its use.The following results were obtained: during load transfer, the activity of the elbow flexor of the wrist when using IE decreased by an average of 41%, biceps – by 21%; during load retention, the activity of the elbow flexor of the wrist when using IE decreased by an average of 42%, biceps – by 52%.Endurance experiments showed a 52-42% decrease in muscle activity when using IE, which positively affects the duration of comfortable work, which increased by an average of 2.5 times.Also, the general physiological condition of the volunteers (pulse, pressure, saturation) when using IE was closer to the standards than withoutAccording to the responses of the volunteers, everyone noticed a slight difference in favor of using IE.IE's help is especially noticeable after a number of completed approaches.Conclusion. A study conducted within the framework of the work to determine the effectiveness and safety of the use of PE in the course of work, including to offset the harm from stereotypical work movements, showed a decrease in the activity of the measured muscles when using PE, which also indicates a decrease in human fatigue, which increases the efficiency of his work.
Decoding forward error correction code in a priori uncertainty
Authors: Dvilyanskiy A. A. , Yurlov A. V. 
Published: February 2025

The purpose of research is to increase the efficiency of decoding noise–resistant block codes in conditions of a priori uncertainty about the parameters used.Methods. In modern systems, the use of noise-resistant block codes with a large codeword length is noted, which allows the permitted code combinations to be sufficiently far apart from each other during encoding and to obtain, during iterative decoding, the possibility of their correct determination at low values of the signal-to-noise ratio in the communication channel. The use of long noise-tolerant codes requires a reduction in the complexity of error correction algorithms, which is estimated by the number of operations of various types per decoding iteration. The number of operations of various types will depend on the parameters of the code and the verification matrix, as well as the decoding algorithm used. The practical implementation of the decoder has a number of limitations, and its design is a difficult task, especially in conditions of a priori uncertainty about the applied code parameters. To solve this problem, it is proposed to use the method of determining the applied LBC verification matrix based on the analysis of the received digital sequence.Results. In the course of the study, a comparative analysis of known methods for determining the parameters of an interference-resistant block code was carried out and a modification of the Gauss method was proposed to solve a system of linear algebraic equations when finding the LBC verification matrix.Conclusion. The proposed method avoids performing a strict sequence of actions according to the well-known Gauss method, as well as reducing time complexity by paralleling calculations and significantly increasing the efficiency of practical implementation of the algorithm for finding the LBC verification matrix.
DIGITAL PAYMENT AND BRAND IMAGE INFLUENCE CONSUMERS' PURCHASING DECISIONS IN THE FOOD SECTOR
Authors: Amanda Septiana , Widiya Avianti  
Published: February 2025

The central government has established the ITE Law No. 11 of 2008 on information and electronic transactions with the aim of improving trade and the national economy and improving public welfare. This is evidenced by the presence of several online payment programs or also known as digital payment applications that provide the ability to make non-cash payments through online transactions. The source of data in this study was obtained from the questionnaire (primary) distributed to the community in Mekargalih Village, Jatiluhur District, Purwakarta Regency. By sampling using non-probability sampling technique with purposive sampling method using slovin formula so that the sample obtained in this study as many as 291 respondents. In addition to ease of payment, another decision in the purchase of products on online shopping platforms is the brand image that affects the purchase intention of consumers. Complaints of payment through the ShopeePay application are perceived by consumers as an obstacle in purchasing, so this study was conducted to determine the effect of digital payments and brand image on purchasing decisions. Based on the results of research conducted, digital payment (X1) and brand image (X2) simultaneously affect the purchase decision. Based on the coefficient of determination test obtained the value of R square (R2) of 0.872. This value can be interpreted that digital payments and brand image are able to influence purchasing decisions by 87.2%.
STRENGTHENING THE ENTREPRENEURIAL SPIRIT AMONG SHARIA BUSINESS ACTORS AT THE DARUL FALLAH ISLAMIC BOARDING SCHOOL, BOGOR
Authors: Adnani Latifah , Yuniarti Yuyun 
Published: February 2025

Islamic boarding schools are currently expected to be financially independent to meet the operational costs of the Islamic boarding school. One way that can be done is by establishing a Business Unit, as was done by the Darul Fallah Islamic boarding school in Bogor by establishing PT. Dafa Techno Agro Mandiri which operates in the field of plant breeding using a tissue culture system. Apart from that, Islamic boarding schools are also expected to be a reference in implementing business based on sharia concepts. Problems faced by PT. Dafa 1) Business managers focus on making products and lack an entrepreneurial spirit. The business sector is handed over to the main director, who is busy and often goes abroad. 2) Business planning adapts to government programs, not market conditions. 3) Sharia business practices are not yet implemented in running it. Business. The research objectives are: a) Analyze the entrepreneurial spirit of PT business managers. Dafa b) Knowing the Implementation of Sharia Business at PT. Dafa. Based on the results of research at PT. Dafa Techno Agro Mandiri (PT. Dafa) that 1) The entrepreneurial spirit of company managers still needs to be improved, especially in terms of creativity in carrying out business activities. Because currently the day-to-day company management hands over the business sector to the main director. Managers and employees are focused on producing seeds, according to the direction of the main director. Not yet business oriented. Apart from that, company planning emphasizes government programs, not general market needs. Apart from that, it is also implementing a strategy to improve relations with student alumni, potato breeders and the government to expand the market. 2) Implementation of sharia business for business actors at PT. Dafa Tecno Agro Mandiri has been implemented. But they do not realize that what they are doing already applies sharia principles. Like managers who work sincerely with the intention of worship, not just pursuing material things. Apart from that, when facing business losses, managers and employees accept it with a good opinion of Allah that Allah is the one who regulates the sustenance of His servants. Competitors are treated as partners. The new concept outlined is that of strengthening the entrepreneurial spirit for sharia business actors, that is, apart from implementing character factors that refer to sharia values, it is also necessary to improve their business spirit. Suggestions for companies 1) We recommend that the entrepreneurial spirit be strongly instilled in all managers and employees. So that business development can be carried out and inspired by all business actors at PT. Dafa . 2) Even though PT. Dafa Teknoagro Mandiri has implemented sharia business in its daily business operations but should be more prominent about the implementation of sharia business in PT companies. Dafa. So it can be used as a reference for Islamic boarding schools and other business actors.
The Influence of Ball Elasticity on Throwing Speed and Grip Strength in Female Handball Players
Authors: GHERMAN Alexandru Andrei , GOMBOŞ Leon , PĂTRAŞCU Adrian , ACHIM Raul 
Published: February 2025

Introduction: This study examines ball elasticity’s impact on throwing speed and palmar strength in female handball players. Objective: We hypothesize that ball elasticity influences throwing speed and palmar strength. Methods: Nine players were grouped by ball elasticity and underwent grip strength measurements, throws, and exercise. Results: Exercise had no significant throwing speed effect; palmar strength decreased. Elasticity showed minimal differences, but hard balls slightly impacted post-exercise speed. Conclusion: Exercise impacted palmar strength, but not throwing speed. Elasticity subtly affected post-exercise speed.
Influența elasticității mingii asupra vitezei de aruncare și a forței de strângere a mâinii la jucătoarele de handbal. Introducere: Acest studiu examinează impactul elasticității mingii asupra vitezei de aruncare și a forței palmare la jucătoarele de handbal. Obiectiv: Emitem ipoteza că elasticitatea mingii influențează viteza de aruncare și puterea palmară. Metode: Nouă jucători au fost grupați în funcție de elasticitatea mingii și au fost supuși măsurătorilor de forță de prindere, aruncări și exerciții. Rezultate: Exercițiul nu a avut un efect semnificativ asupra vitezei de aruncare; puterea palmară a scăzut. Elasticitatea a arătat diferențe minime, dar mingile dure au afectat ușor viteza post-exercițiu. Concluzie: Exercițiul a afectat forța palmară, dar nu viteza de aruncare. Elasticitatea a afectat subtil viteza post-exercițiu.
Cuvinte-cheie: elasticitate a mingii, viteză de aruncare, forță palmară, handbal, oboseală indusă de exercițiu
Article history: Received: 2024 November 21; Revised 2025 January 24; Accepted 2025 January 27; Available online: 2025 February 10; Available print: 2025 February 28