bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of habitat quality and ecological flow in a regulated waterway
Authors: Nan Junhu , Liu Yian , Chen Yao , Zhang Shufeng 
Published: December 2022

AbstractDam control changes the hydraulic environment and hydrological rhythm of rivers; to explore the causes of fish habitat loss and influence of river regulation in such rivers, the downstream curving reaches of Shaying River were cut off. Grass, silver, and bighead carp were selected as the research targets, and the impact of waterway regulation and the effect of gravel mounds on the target fish habitat were studied using numerical simulation. The results show that the original channel's hydraulic environment is similar to the artificial channel, and the target fish spawning habitat is limited, which is an important reason for the shortage of fish resources in the research area. The reconstructed channel can meet the river's navigation demands and improve the channel's flood discharge capacity. The habitat method was used to estimate the minimum and appropriate ecological flows of the target fish at each growth stage in the original and reconstructed rivers. Under the appropriate ecological flow, the weighted usable area (WUA) of juvenile, migratory, and spawning habitats of the target fish in the reconstructed river increased by 168, 24, and 580%, respectively, compared to the original channel, while the WUA of adult fish that preferred a slow-water environment decreased by 62%, effectively improving the target fish's spawning environment.
DNA Vaccines to Improve Immunogenicity and Effectiveness in Cancer
Vaccinations: Advancement and Developments
Authors: Singh Arun Kumar , Malviya Rishabha 
Published: December 2022

Abstract:
DNA vaccine is a creative and promising method for cancer treatment. As part of cancer
immunotherapy, one or more antigen-specific immune responses are triggered or strengthened using
DNA vaccines for cancer immunotherapy, which convey one or more genes encoded by tumour antigens
to the immune system. Vaccine efficacy may be greatly increased by new delivery routes, the incorporation
of molecular active ingredients and immunomodulatory signals, the modification of
prime-boost protocols, or the inhibition of immunological checkpoints. It is possible to overcome the
self-tolerance of many tumour antigens by using a mix of adaptive immune system and vaccine design
strategies to generate protective adaptive immune responses. Both preventative and therapeutic vaccinations
are being developed using this technology in several clinical investigations on DNA cancer
immunotherapy. This study examines the immunogenicity and efficacy of DNA vaccines for immunotherapy.
A Nomogram Prediction Model Based on Tissue Window for the Prognosis
of Patients with Acute Ischemic Stroke Undergoing Thrombectomy
Authors: Kong Yan , Zhao Jie-ji , Chen Hui-ru , Cui Jun-yi , Ye Meng-fan , Li Tan , Cai Xiu-Ying , Ma Lin-qing , Zhang Run-ping 
Published: December 2022

Objective:
Thrombectomy greatly improves the clinical prognosis of patients with acute
ischemic stroke (AIS). The aim of this study is to develop a nomogram model that can predict the
prognosis of patients with acute ischemic stroke undergoing thrombectomy.

Methods:
We retrospectively collected information of patients with acute ischemic stroke who were
admitted to the stroke Green Channel of the First Affiliated Hospital of Soochow University from
September 2018 to May 2022. The main outcome was defined as a three-month unfavorable outcome
(modified Rankin Scale 3-6). Based on the results of multivariate regression analysis, a nomogram
was established. We tested the accuracy and discrimination of our nomogram by calculating
the consistency index (C-index) and plotting the calibration curve.

Results:
National Institutes of Health Stroke Scale (NIHSS) score (OR, 1.418; 95% CI, 1.177-1.707;
P＜0.001), low density lipoprotein cholesterol (LDL-C) (OR, 2.705; 95% CI, 1.203-6.080; P =
0.016), Alberta Stroke Program Early Computed Tomography Score (ASPECTS) (OR, 0.633; 95%
CI, 0.421-0.952; P = 0.028), infarct core volume (OR, 1.115; 95% CI, 1.043-1.192; P = 0.001) and
ischemic penumbra volume (OR, 1.028; 95% CI, 1.006-1.050; P = 0.012) were independent risk
factors for poor clinical prognosis of AIS patients treated with thrombectomy. The C-index of our
nomogram was 0.967 and the calibration plot revealed a generally fit in predicting three-month unfavorable
outcomes. Based on this nomogram, we stratified the risk of thrombectomy population.
We found that low-risk population is less than or equal to 65 points, and patients of more than 65
points tend to have a poor clinical prognosis.

Conclusion:
The nomogram, composed of NIHSS, LDL-C, ASPECTS, infarct core volume and
ischemic penumbra volume, may predict the clinical prognosis of cerebral infarction patients treated
with thrombectomy.
Fear of COVID-19, Stress and Coping Strategies among Nurses during the COVID-19 Pandemic’s Second Wave: A Quasi-Intervention Study
Authors: Omar Doaa I. , Amer Samar A. , Abdelmaksoud Abeer E. 
Published: December 2022

Background:
The COVID-19 pandemic and its related consequences caused a higher risk of mental health problems for nurses. Hence, this study aims to reduce the level of fear and stress related to the COVID-19 pandemic and promote active coping among Egyptian nurses.

Methods:
This quasi-intervention study was conducted on 125 nurses working at Benha’s University hospitals, who were selected by a systematic random sampling technique within the time interval of March 2021 to July 2021. The study was conducted using the fear of COVID-19 scale, the stress scale of depression, anxiety and stress scales, and the Brief (COPE) inventory scale.

Results:
The mean ages of the studied nurses were 36.70 ± 9.50. Almost half of the studied nurses were males and married. Before the intervention, 47.2% of nurses had severe stress levels while 82.4% had a high level of fear of COVID-19. Experience years, type of department, and worries about vaccine side effects were the predictors of the fear of COVID-19. A significant difference (p = .000) was found between both mean stress and fear scores pre-intervention (15.27 ± 5.47 and 25.56 ± 6.13) and post-intervention (4.87 ± 2.14 and 11.92 ± 2.43). The most prevalent coping strategies among nurses before the intervention were self-distraction (5.03 ± 1.53), followed by behavioral disengagement and self-blaming. However, after the intervention, religion was found to be the utmost coping mechanism (6.12 ± 1.17), followed by positive reframing and acceptance.

Conclusion:
The majority of the nurses in the study reported a significant fear of COVID-19, and around half of the nurses had severe stress as a result. After the intervention, the stress and fear scores were reduced by half or even less. Age, longer work experience, and worries about the vaccine were the predictors of fear of COVID-19. The coping strategies used after the intervention shifted toward active coping strategies.
Clinical Trial Registration Number: 10-11-008-701
Patients’ Perceptions on the Factors Contributing to Non-conversion after Two Months of Tuberculosis Treatment at Selected Primary Healthcare Facilities in the Ekurhuleni Health District, South Africa
Authors: Baloyi Ntwanano Fiona , Manyisa Zodwa Margaret 
Published: December 2022

Background:
Tuberculosis patients’ non-conversion is one of the factors impeding the ‘End TB’ strategies in South Africa. Several reasons have been recognised as contributing to patients with TB non-conversion, including TB illiteracy, denial of TB infection, reluctance to honour follow-up visits, and an unwillingness to take prescribed treatment for six months.

Objective:
In light of this, this study aimed at exploring and describing factors contributing to patients with pulmonary TB non-conversion at two and three months of treatment at selected primary healthcare facilities in the Ekurhuleni Health District, Gauteng province.

Methods:
A qualitative, explorative and descriptive research design was adopted with eight purposively sampled patients receiving TB care from five selected primary healthcare facilities. Semi-structured interviews were utilised to collect data from eight purposively sampled participants, who were interviewed on what they perceived to be factors contributing to patients with TB non-conversion at two and three months of treatment.

Results:
The study found that patients with TB attending the selected primary healthcare facilities experience psychosocial problems, such as shortage of food and lack of family support, as well as insufficient patient healthcare literacy.

Conclusion:
The study recommends that enhanced patient education be given from the time a patient starts TB treatment. The involvement of multi-disciplinary teams and other stakeholders is important in the management of patients with TB. Furthermore, the outreach team must provide health education to patients with TB family members, so that they can support the patients with TB to comply with treatment. Family support must be emphasised because it encourages patients with TB to comply with the course of treatment.
Psychological Responses to Coronavirus Disease 2019 amongst Healthcare Workers in South Africa during the Pandemic
Authors: Nel Kathryn , Govender Indiran , Katjene Mathews , Govender Saraswathie , Mabila Thembinkosi 
Published: December 2022

Background:
It is important to understand HCWs’ (healthcare workers) psychological responses to the Coronavirus disease 2019 (COVID-19) pandemic as they are exposed to the virus on a daily basis. This study helps identify some of the challenges they face.

Aim:
The overall aim of the study was to investigate psychological responses to COVID-19, including vaccinations and stressors, amongst healthcare HCWs in South Africa during the pandemic.

Setting:
HCWs who worked in private and state hospitals and private practice in Tshwane, South Africa.

Methods:
A quantitative approach using a cross-sectional survey design was used. Several standardised and validated questionnaires were used in the survey including the Coronavirus-19 Fear Scale, the COVID-19-related stigma scale and the COVID-19 stress scale. A purposive sample (N=103) was analysed using descriptive statistics and chi-square.

Results:
There were 103 completed questionnaires. Many (76% and 54%) either knew someone close who contracted COVID or died from COVID-19, respectively. Most (58%) were in favour of being vaccinated. A significant proportion (42%; p= 0.009) of the HCWs felt uncomfortable when thinking about COVID. Physical reactions such as sweating, or a pounding heart were reported by 17% of the HCWs. A majority of the HCWs disagreed with any form of stigmatization of COVID-19. Most of the HCWs expressed a need for mental health support during the COVID-19 pandemic. About three-quarters of the respondents expressed a need to talk to someone about their worries about COVID-19.

Conclusion:
Most of the respondents either knew someone who either contracted COVID-19 or died because of it. Many experienced anxiety symptoms when thinking about COVID-19. Many HCWs reported anxiety and stress symptoms such as insomnia, palpitations, sweating and difficulty concentrating. An overwhelming majority of the HCWs stated that people should not be discriminated against or stigmatized in any way because of COVID-19. The majority of the HCWs expressed a need for psychological support during the COVID-19 pandemic. About 20% of the HCWs were against being vaccinated. This is worrisome as they are at high risk. The HCWs clearly expressed a need for more attention and support towards their mental health during the COVID-19 pandemic.
The Impact of COVID-19 on the Prevalence and Perception of Telehealth Use in the Middle East and North Africa Region: Survey Study
Authors: Shamiyah Khalid Adnan , Whitebridge Simon , Kumar Nitya , Aljenaee Khaled , Atkin Stephen L , Ali Khawla Fuad 
Published: December 2022

Background
Due to the COVID-19 pandemic, telehealth has become a safer way to access health care. The telehealth industry has rapidly expanded over the last decade as a modality to provide patient-centered care. However, the prevalence of its use and patient acceptability remains unclear in the Middle East and North Africa (MENA) region.

Objective
The primary aim was to assess the prevalence of telehealth use before and during the pandemic by using social media (Instagram) as an online platform for survey administration across different countries simultaneously. Our secondary aim was to assess the perceptions regarding telehealth among those using it.

Methods
An Instagram account that reaches 130,000 subjects daily was used to administer a questionnaire that assessed the current prevalence of telehealth use and public attitudes and acceptability toward this modality of health care delivery during the COVID-19 pandemic.

Results
A total of 1524 respondents participated in the survey (n=1356, 89% female; median age 31 years), of whom 97.6% (n=1487) lived in the Gulf Cooperation Council (GCC) region. Prior to COVID-19, 1350 (88.6%) had no exposure to telehealth. Following the COVID-19 pandemic, telehealth use increased by 251% to a total of 611 users (40% of all users). About 89% (571/640) of telehealth users used virtual visits for specialist visits. Of the 642 participants who reported using telehealth, 236 (36.8%) reported their willingness to continue using telehealth, 241 (37.5%) were unsure, and 164 (25.5%) did not wish to continue to use telehealth after the COVID-19 pandemic. An inverse trend, although not statistically significant, was seen between willingness to continue telehealth use and the number of medical comorbidities (odds ratio [OR] 0.81, 95% CI 0.64-1.03; P=.09). Compared to the respondents who chose only messaging as the modality they used for telehealth, respondents who chose both messaging and phone calls were significantly less likely to recommend telehealth (OR 0.42, 95% CI 0.22-0.80; P=.009). Overall, there was general satisfaction with telehealth, and respondents reported that telehealth consultations made them feel safer and saved both time and money.

Conclusions
Telehealth use increased dramatically after the COVID-19 pandemic, and telehealth was found to be acceptable among some young adult groups on Instagram. However, further innovation is warranted to increase acceptability and willingness to continue telehealth use for the delivery of health care.
Using Intervention Mapping to Develop an mHealth Intervention to Support Men Who Have Sex With Men Engaging in Chemsex (Budd): Development and Usability Study
Authors: Herrijgers Corinne , Platteau Tom , Vandebosch Heidi , Poels Karolien , Florence Eric 
Published: December 2022

Background
Chemsex refers to the intentional use of drugs before or during sex among men who have sex with men (MSM). Engaging in chemsex has been linked to significant negative impacts on physical, psychological, and social well-being. However, no evidence-based support tools have addressed either these harms or the care needs of MSM who engage in chemsex.

Objective
The purpose of this paper was to describe the development of a mobile health intervention (named Budd) using the intervention mapping protocol (IMP). Budd aims to support and inform MSM who participate in chemsex, reduce the negative impacts associated with chemsex, and encourage more reasoned participation.

Methods
The IMP consists of 6 steps to develop, implement, and evaluate evidence-based health interventions. A needs assessment was carried out between September 2, 2019, and March 31, 2020, by conducting a literature study and in-depth interviews. Change objectives were selected based on these findings, after which theory-based intervention methods were selected. The first version of the intervention was developed in December 2020 and pilot-tested between February 1, 2021, and April 30, 2021. Adjustments were made based on the findings from this study. A separate article will be dedicated to the effectiveness study, conducted between October 15, 2021, and February 24, 2022, and implementation of the intervention. The Budd app went live in April 2022.

Results
Budd aims to address individual factors and support chemsex participants in applying harm reduction measures when taking drugs (drug information, drug combination tool, and notebook), preparing for participation in a chemsex session (articles on chemsex, preparation tool, and event-specific checklist), planning sufficient time after a chemsex session to recover (planning tool), seeking support for their chemsex participation (overview of existing local health care and peer support services, reflection, personal statistics, and user testimonials), taking HIV medication or pre-exposure prophylaxis in a timely manner during a chemsex session (preparation tool), and contacting emergency services in case of an emergency and giving first aid to others (emergency information and personal buddy).

Conclusions
The IMP proved to be a valuable tool in the planning and development of the Budd app. This study provides researchers and practitioners with valuable information that may help them to set up their own health interventions.

International Registered Report Identifier (IRRID)
RR1-10.2196/39678
Faktor Penyebab Ketidakpatuhan terhadap Peraturan Pangan: Studi Kualitatif pada Distributor Pangan Olahan di Kota Gorontalo
Authors: Nurhayati Lyna , Satibi Satibi , Sumarni Sumarni 
Published: December 2022

Kepatuhan pelaku usaha terhadap peraturan pangan penting dalam menjamin keamanan produk yang diproduksi atau diedarkannya. Tujuan penelitian ini adalah menggali faktor-faktor penyebab ketidakpatuhan pelaku usaha distributor pangan olahan terhadap peraturan di bidang pangan di Kota Gorontalo. Penelitian ini menggunakan metode penelitian kualitatif deskriptif. Pengumpulan data dilakukan dengan wawancara mendalam yang direkam dengan alat perekam. Responden utama adalah pelaku usaha yang memenuhi syarat yang telah ditetapkan dengan mempertimbangkan jenis sarana dan jenis pelanggarannya. Jenis sarana distribusi yang terwakili yaitu kios, toko, toko berantai dan distributor besar pangan olahan. Jumlah responden utama yang diwawancarai berjumlah 12 responden, terdiri dari 5 responden utama dan 7 responden konfirmasi (tiap sarana 1 responden utama kecuali sarana 1 sebanyak 2 responden utama). Hasil wawancara responden utama ditranskrip untuk kemudian dianalisis. Proses analisis meliputi penentuan pernyataan responden utama yang dianggap menjawab pertanyaan penelitian, konfirmasi pernyataan tersebut ke responden konfirmasi, coding, penentuan subkategori dan kategori. Hasil penelitian ini menunjukkan beberapa faktor yang menyebabkan ketidakpatuhan pelaku usaha terhadap peraturan di bidang pangan. Faktor penyebab tersebut adalah kurangnya pengetahuan pelaku usaha terhadap peraturan, faktor keuangan yang berasal dari tingginya permintaan konsumen terhadap praktek yang dilarang, serta faktor ketidakpedulian yang dikarenakan perilaku malas dan kesibukan pada pekerjaan lain.
The Production of Superior Hybrid Jawa Super Chicken as a Food Security Strategy During COVID-19 Pandemic in Ngoro-Oro Village, Patuk, Gunung Kidul, Yogyakarta
Authors: Saragih Hendry , Nuriliani Ardaning , Erwanto Yuny , Susanto Adi , Damayanti Sari’ah Cintami , Mahendra Bima , Conara Flaﬁani Cios , Nur Hidayah Lailly Tsania 
Published: December 2022

During the COVID-19 outbreak, economic sectors slowed down and caused a signiﬁcant impact on almost any level of society, especially the middle to lower class income. Thus, a strategy needs to be developed to overcome this situation. The Ngoro-Oro Village has potency in the livestock sector, especially in the development of superior hybrid Jawa super chicken. Therefore, the purposes of our community service in the Ngoro-Oro Village were to develop superior hybrid Jawa super chicken and use black soldier ﬂy larvae as an alternative feed for chicken. We distributed 105 Jawa super hens aged ± three months and 21 superior free-range roosters. Furthermore, the hens and rooster were mated at the age of ± six months with a ratio of 5:1.The hybrid chickens were evaluated for their body weight and morphometric measurements until the age of four months. We also monitored the farmer community’s use of black soldier ﬂy larvae as an alternativ e feed for chickens. The hybrid chicken at the age of 4 months old has a body weight of about 971.64 ± 271.06 grams with a height of about 41.73 ± 5.87 cm, head’s length of 5.01 ± 0.44 cm, body length of 22.82 ± 3.14 cm, body width of 10.68 ± 1.49 cm, wing’s length 19.14 ± 2.67 cm, thigh’s length 11.95 ± 1.71 cm, and leg’s length is about 7.91 ± 1.41 cm. Moreover, Ngoro-Oro farmers can improve the community’s economy by selling superior hybrid Jawa super chicken at a price 75,000 – 85,000 rupiahs per head. Through all of this community service program, it could be concluded that superior hybrid Jawa super chicken is potential to be developed as broiler, and the farmer community could develop black soldier ﬂy larvae as an alternative feed for chicken.
Innovative materials and technologies in housing construction: importance and prospects
Authors: Vasilyeva Elena Yu. 
Published: December 2022

Introduction. The trends and prospects for the application of innovations in the housing construction in the Russian Federation are considered in the article.
Materials and methods. The system approach, methods of structural analysis, classification and grouping, comparative and statistical analysis, forecasting and expert evaluations were used in the research. Works of Russian and foreign authors, experience of construction companies, statistics presented by Rosstat (Federal state Statistics Service), materials of the Moscow Agency of innovations, materials of business programmes of specialized exhibitions, conferences and forums were used as the material for the research.
Results. The author systematized the current innovation trends broken down into (1) development and application of innovative construction materials and (2) creation and implementation of innovative technologies in construction. All innovations eventually reduce costs and terms; improve the quality of or cause an increase in the environmental friendliness of construction. The author formulated the basic condition of expediency of innovation introduction, or the improvement of an indicator of an innovative project in comparison with the basic option, other things being equal. The analysis of the situation also allowed identifying barriers, interfering with the introduction of innovations in the housing construction in the Russian Federation.
Conclusions. The analysis has proved the demand and certain prerequisites for the development of innovative activities in the housing construction in Russia. Certain conditions are required for overcoming the existing barriers, preventing the wide-scale use of innovative technologies in housing construction, such as the better assessment of innovative projects, taking into account the features of housing construction; and consequently, a rise in investments into innovative housing construction projects; reasonable state regulation; regulatory framework improvement; advanced training of executives and providing the industry with managers, acting as innovators. Low-rise and single-family houses are the best options for innovations.