bluuebunny/crossref_metadata_2025_split huggingface dataset:
qSUB2: A novel QTL with positive epistasis with SUB1 locus enhances submergence tolerance in rice
Authors: Akintayo Oluyemi , Daniel Isaac , Afeez Shittu , Jolayemi Okanlawon , Semwal Vimal , Venuprasad Ramaiah 
Published: February 2023

AbstractClimate change is expected to significantly increase submergence stress of lowland rice (Oryza sativa) production in Africa. There is a need to further improve the ability of SUB1 gene to tolerate submergence stress. Genetic control of submergence tolerance was studied in a moderately tolerant to submergence African rice landrace “TOS6454.” Three mapping populations with a total of 1182 lines were developed by crossing TOS6454 with three popular rice varieties of West Africa that are high‐yielding but submergence susceptible, that is, FARO44, FARO52, and FARO60. The screening for submergence was conducted at the Africa Rice Center (AfricaRice) station in Ibadan, Nigeria during 2016–2018. The three mapping populations were genotyped with single nucleotide polymorphic markers either on the Kompetitive allele specific PCR or the DArTseq platforms. Quantitative trait locus (QTL) analysis revealed five different QTLs on chromosomes 1, 2, 3, 4, and 9. The QTLs on chromosomes 2 (qSUB2) and 9 (qSUB9) had consistent large effects and the tolerance alleles were contributed by TOS6454. The QTL on chromosome 9 (qSUB9) had a large effect on submergence tolerance in all three mapping populations. This QTL had a highest logarithm of odds (LOD) score of 30.46 and explained as much as 27.7% phenotypic variation (R2), with an additive effect of up to 9.39. The QTL on chromosome 2 (qSUB2) had a highest LOD score of 10.78 and explained up to 10.8% R2 for this trait. Furthermore, qSUB2 had positive epistasis with qSUB9 which further increased submergence tolerance. A total of 57 lines carrying both qSUB2 and qSUB9 alleles were superior to all other lines in submergence tolerance. qSUB9 co‐segregated with ART5 a marker for the SUB1 gene; thus, it is suggested that qSUB9 is the same as the well‐known SUB1 gene. Pyramiding qSUB2 with the SUB1 gene locus is expected to further improve submergence tolerance in elite rice varieties.
A circular monopole antenna for bandwidth enhancement using cylinder slots with triple band notch characteristics
Authors: Y Venkata Lakshmaiah , Roy Bappadittya 
Published: February 2023

SummaryThis article introduces a super wideband along with three notch bands circular patch monopole antenna. The design structure is applicable for microwave and high‐speed wireless devices (2.19 to 25 GHz). In order to create a broad band, a ring dimension circular patch is used. To generate three notch bands, six symmetrical tiny cylinder stubs are introduced on the ground. These notch band frequencies can eliminate unwanted interference from various wireless frequencies, which mainly cover three notch bands: 5.5–7.3, 12.05–14.46, and 17.71–19.5 GHz. The steady radiation, super bandwidth, and stable gain properties expand when the ring patch and line feed are combined. It is excellent for many UWB applications because of its compact size (39 × 29 mm 2) and large bandwidth (166.97% fractional bandwidth). This model employs various size reduction and matching approaches to get a better response. The mechanisms of these structures are identified, and overall performance is compared with parametric analysis, tables, and figure.
Using PhyloSuite for molecular phylogeny and tree‐based analyses
Authors: Xiang Chuan‐Yu , Gao Fangluan , Jakovlić Ivan , Lei Hong‐Peng , Hu Ye , Zhang Hong , Zou Hong , Wang Gui‐Tang , Zhang Dong 
Published: February 2023

AbstractPhylogenetic analysis has entered the genomics (multilocus) era. For less experienced researchers, conquering the large number of software programs required for a multilocus‐based phylogenetic reconstruction can be somewhat daunting and time‐consuming. PhyloSuite, a software with a user‐friendly GUI, was designed to make this process more accessible by integrating multiple software programs needed for multilocus and single‐gene phylogenies and further streamlining the whole process. In this protocol, we aim to explain how to conduct each step of the phylogenetic pipeline and tree‐based analyses in PhyloSuite. We also present a new version of PhyloSuite (v1.2.3), wherein we fixed some bugs, made some optimizations, and introduced some new functions, including a number of tree‐based analyses, such as signal‐to‐noise calculation, saturation analysis, spurious species identification, and etc. The step‐by‐step protocol includes background information (i.e., what the step does), reasons (i.e., why do the step), and operations (i.e., how to do it). This protocol will help researchers quick‐start their way through the multilocus phylogenetic analysis, especially those interested in conducting organelle‐based analyses.
Vocational rehabilitation counselor burnout profiles and mindfulness
Authors: Lu Junfei , Brickham Dana , Jaeger Brian J. , Lo Chu‐Ling 
Published: February 2023

AbstractBurnout of vocational rehabilitation (VR) counselors can not only lead to decreased job satisfaction and turnover but also damage the quality of VR services provided to clients with disabilities. It is an ethical obligation for VR counselors to engage in self‐care practices to prevent burnout. The current study surveyed 147 VR counselors from two State VR agencies about their current level of burnout and mindfulness related facets. Based on the latent profile analysis, four unique counselor burnout profiles were identified. These were well‐adjusted‐counselor, type I preserving‐counselor, type II preserving‐counselor, and disconnected‐counselor. Moreover, the results of multivariate analysis of variance tests disclosed that VR counselors with different counselor burnout profiles varied significantly on the mindfulness measure, especially in the facets of acting with awareness and non‐judging. The results have unique research and practice implications for the prevention and treatment of burnout of VR counselors.
Community‐level socioeconomic distress is associated with nutritional status in adults with sickle cell anemia
Authors: Ally Syeda Akila , Han Jin , Sun Ryan , Molokie Robert E. , Gordeuk Victor R. , Lash James P. , Saraf Santosh L. 
Published: February 2023

AbstractSickle cell anemia (SCA) negatively impacts the ability to achieve educational and occupational goals increasing vulnerability to socioeconomic challenges. In a cross‐sectional analysis of 332 SCA adults, we investigated whether the distressed community index (DCI) was associated with SCA‐related complications and nutritional status. More patients with higher DCI had Medicaid insurance. A higher DCI was independently associated with tobacco use and lower body mass index, serum albumin, and vitamin D 25‐OH levels after adjusting for insurance status but was not associated with SCA‐related complications. Future studies investigating access to healthy foods may help improve health equity in patients with SCA.
Comparison of moisture sources of summer precipitation in 1998 and 2020 in the middle and lower reaches of Yangtze River basin
Authors: Chen Jihua , Li Ying , Xiong Biao , Wang Yingfei , Zhou Shuangshuang , Huang Yingping 
Published: February 2023

AbstractThe persistent heavy precipitation during summer in 1998 and 2020 in the middle and lower reaches of the Yangtze River basin (MLYRB) caused the most influential floods in the region during recent 30 years. Previous studies paid lots of attention to those events by analysing the spatial–temporal distributions and the circulation backgrounds; however, the comparison of moisture contribution to summer precipitation in the MLYRB in 1998 and 2020 have rarely been well addressed. This study tracked the moisture sources of summer precipitation in 1998 and 2020 in the MLYRB based on an Eulerian moisture tracking model (WAM‐2layers) forced with ERA5 dataset and explored the similarities and differences of moisture transport and moisture contribution during the two periods. Results showed that the moisture contribution to summer precipitation in the MLYRB mainly transported by the southwest monsoon system, with the major sources extended across the Indo‐China Peninsula, the Bay of Bengal and the Arabian Sea, to the south Indian Ocean. During the summer of 1998 and 2020, increased moisture contributions were mainly from the southwestern sources, particularly the Indo‐China Peninsula and its surroundings. Meanwhile, decreased moisture contributions were found from the local recycling and the northeastern sources. In comparison with summer 1998, there were less moisture can be transported from the low‐latitude oceans (particularly the Arabian Sea and the Bay of Bengal) to the MLYRB during summer 2020, except for the Northwestern Pacific.
An exploratory analysis of internal communication in times of the COVID‐19 pandemic
Authors: Gomes Patrícia , Santos Eulália , Martins Elisete 
Published: February 2023

AbstractCommunication is a key element for the success of any organization. The present study aims to construct and validate a scale of perception of internal communication. It is also intended to assess whether there are differences in internal communication between employees who are teleworking and those who are in‐person work in times of the COVID‐19 pandemic. The methodology used is quantitative in nature based on a questionnaire survey, with the sample consisting of 837 Portuguese individuals in a work context. The results show that the structure of the scale of perception of internal communication is composed of three factors: organizational information, communication with supervisors, and communication between colleagues. The perception of internal communication in the factor organizational information showed higher levels in workers who are in telecommuting situations. It is hoped that this work will enrich the academy and enable managers to use communication more effectively so that the organizations they manage become more competitive.
Selecting relevant moderators with Bayesian regularized meta‐regression
Authors: Van Lissa Caspar J. , van Erp Sara , Clapper Eli‐Boaz 
Published: February 2023

AbstractWhen meta‐analyzing heterogeneous bodies of literature, meta‐regression can be used to account for potentially relevant between‐studies differences. A key challenge is that the number of candidate moderators is often high relative to the number of studies. This introduces risks of overfitting, spurious results, and model non‐convergence. To overcome these challenges, we introduce Bayesian Regularized Meta‐Analysis (BRMA), which selects relevant moderators from a larger set of candidates by shrinking small regression coefficients towards zero with regularizing (LASSO or horseshoe) priors. This method is suitable when there are many potential moderators, but it is not known beforehand which of them are relevant. A simulation study compared BRMA against state‐of‐the‐art random effects meta‐regression using restricted maximum likelihood (RMA). Results indicated that BRMA outperformed RMA on three metrics: BRMA had superior predictive performance, which means that the results generalized better; BRMA was better at rejecting irrelevant moderators, and worse at detecting true effects of relevant moderators, while the overall proportion of Type I and Type II errors was equivalent to RMA. BRMA regression coefficients were slightly biased towards zero (by design), but its residual heterogeneity estimates were less biased than those of RMA. BRMA performed well with as few as 20 studies, suggesting its suitability as a small sample solution. We present free open source software implementations in the R‐packagepema(for penalized meta‐analysis) and in the stand‐alone statistical program JASP. An applied example demonstrates the use of the R‐package.
Refractometric Imaging and Biodetection Empowered by Nanophotonics
Authors: Sun Shengqi , Wu Lan , Geng Zihan , Shum Perry Ping , Ma Xingyi , Wang Jiawei 
Published: February 2023

AbstractAdvancing clinical and nonclinical diagnostic technologies is particularly crucial for improved preparedness for the next pandemic and other global healthcare challenges. To this end, marrying advanced microscopic imaging with chip‐scale bioanalytical systems provides fresh modalities by analyzing signals of transmitted, reflected, or scattered light waves. This review brings clarity to the latest progress of refractometric imaging and biodetections on a chip, in which interferences and resonances as cornerstones of optics and plasmonics are breaking new ground. A vast range of nanophotonic and plasmonic transducers are discussed, ranging from planar films, nanoarrays, and waveguiding resonators to holistic designs. The augmented bioanalyses cover immunoassays, single‐molecule analysis, and motion tracking of bacterial pathogens and cells. Compared to single‐point spectroscopic measurements, imaging‐empowered approaches are rapidly evolving with greatly promoted signal‐noise ratio, spatial‐temporal resolutions, multiplexability, and throughput, which can be accomplished in a compact cradle system with minimized bulky components in a spectrometer‐free manner. Besides, advances in machine learning technologies applied for data analytics and transducer designs are highlighted. All in all, there are unlimited opportunities for new optical structures, principles, and ways of data retrieval to tap in, which will raise technological impacts on unveiling fundamental issues in life science and advancing global healthcare technologies.
How Single Site Mutations Can Help Understanding Structure Formation of Amyloid β1−40
Authors: Schwarze Benedikt , Huster Daniel 
Published: February 2023

AbstractAmyloid fibrils represent the structural endpoint on the energetic (mis)folding landscape of very many proteins. Physiologically, amyloid fibrils are observed as a characteristic hallmark in misfolding diseases often associated with degenerative and neurodegenerative disorders. In the beginning of the scientific discussion, the focus is laid on the fibrillar state, but over the time it becomes increasingly clear that low molecular weight and transient aggregates are of crucial importance for pathological mechanisms. Structural studies find different intra‐ and intermolecular contacts for the most well‐studied peptide amyloid β (Aβ) depending on the stage of fibrillation. In particular, the contact between residues phenylalanine 19 (F19) and leucine 34 (L34) seems to be highly conserved, suggesting that it must be of particular significance for Aβ misfolding and possibly the pathological properties of the peptide. This review aims to highlight the rational and the usefulness of point mutations in Aβ peptides and their impact on the critical interstrand contact F19−L34 depending on the stage of fibrillation. While the amyloid structure of Aβ is very robust against quite a few modifications, the toxicity of mutated Aβ molecules highly depends on the F19−L34 contact.
Multimodal Imaging of Substantia Nigra in Parkinson's Disease with Levodopa‐Induced Dyskinesia
Authors: Su Dongning , Gan Yawen , Zhang Zhe , Cui Yusha , Zhang Zhijin , Liu Zhu , Wang Zhan , Zhou Junhong , Sossi Vesna , Stoessl A. Jon , Wu Tao , Jing Jing , Feng Tao 
Published: February 2023

AbstractBackgroundDegeneration of the substantia nigra (SN) may contribute to levodopa‐induced dyskinesia (LID) in Parkinson's disease (PD), but the exact characteristics of SN in LID remain unclear.ObjectiveTo further understand the pathogenesis of patients with PD with LID (PD‐LID), we explored the structural and functional characteristics of SN in PD‐LID using multimodal magnetic resonance imaging (MRI).MethodsTwenty‐nine patients with PD‐LID, 37 patients with PD without LID (PD‐nLID), and 28 healthy control subjects underwent T1‐weighted MRI, quantitative susceptibility mapping, neuromelanin‐sensitive MRI, multishell diffusion MRI, and resting‐state functional MRI. Different measures characterizing the SN were obtained using a region of interest–based approach.ResultsCompared with patients with PD‐nLID and healthy control subjects, the quantitative susceptibility mapping values of SN pars compacta (SNpc) were significantly higher (P = 0.049 and P = 0.00002), and the neuromelanin contrast‐to‐noise ratio values in SNpc were significantly lower (P = 0.012 and P = 0.000002) in PD‐LID. The intracellular volume fraction of the posterior SN in PD‐LID was significantly higher compared with PD‐nLID (P = 0.037). Resting‐state fMRI indicated that PD‐LID in the medication off state showed higher functional connectivity between the SNpc and putamen compared with PD‐nLID (P = 0.031), and the functional connectivity changes in PD‐LID were positively correlated with Unified Dyskinesia Rating Scale total scores (R = 0.427, P = 0.042).ConclusionsOur multimodal imaging findings highlight greater neurodegeneration in SN and the altered nigrostriatal connectivity in PD‐LID. These characteristics provide a new perspective into the role of SN in the pathophysiological mechanisms underlying PD‐LID. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
The u‐p approximation versus the exact dynamic equations for anisotropic fluid‐saturated solids. I. Hyperbolicity
Authors: Osinov Vladimir A. 
Published: February 2023

AbstractThe numerical solution of dynamic problems for porous fluid‐saturated solids is often performed with the use of simplified equations known as the u‐p approximation. The simplification of the equations consists in neglecting some acceleration terms, which is justified for a certain class of problems related, in particular, to geomechanics and earthquake engineering. There exist two u‐p approximations depending on how many acceleration terms are neglected. All comparative studies of the exact and u‐p formulations are focused on the question of how well the u‐p solutions approximate those obtained with the exact equations. In this paper, the equations are compared from a different point of view, addressing the question of well‐posedness of boundary value problems. The exact equations must be hyperbolic and satisfy the corresponding hyperbolicity conditions for the boundary value problems to be well posed. The u‐p equations are not of the form to which the conventional definition of hyperbolicity applies. A slight extension of the approach makes it possible to derive hyperbolicity conditions as necessary conditions for well‐posedness for the u‐p approximations. The hyperbolicity conditions derived in this paper for the u‐p approximations are formulated in terms of the acoustic tensor of the skeleton. They differ essentially from the hyperbolicity conditions for the exact equations.
Sustainability motives, values and communication of slow fashion business owners
Authors: Ramonienė Lineta 
Published: February 2023

AbstractResearch on sustainable consumption is increasing however, it mostly focuses on commercial products. Fashion industry in general remains understudied especially small size business in sustainable fashion. Even this segment continues to be neglected in research, it creates a significant impact on sustainability. The study is carried in Lithuania. While sustainability is regarded as the business standard in neighboring countries, especially Scandinavia, Lithuania is still learning how to become more conscious and sustainable. Although the country has the capacity to lead sustainability in the region, there is inadequate education on this matter. Regardless, several local businesses and governments agree that incorporating sustainability is a single clear route to economic growth. The paper aims to understand motives and values of Lithuanian sustainable clothing business owners and explore how they communicate these motives and values. The study employs a qualitative approach of in‐depth semi‐structured interviews. The analysis is guided by the framework of grounded theory, which leads to the conception of four themes: (1) Initiating a Change; (2) Respectful and Responsible Approach; (3) Slowness; (4) Personal and Purposeful Communication. A possible limitation of this study is the language barrier. Participants could choose whether they wished to speak in English or Lithuanian. Three out of seven chose to speak their native language, while four agreed to speak in English. Although English‐speaking participants did not show any difficulty expressing themselves, their interviews turned out to be shorter than those conducted in Lithuanian. Findings indicate that the motives, values, and communication procedures of the owners are reflected in bringing about a change in consumers' minds and actions, taking responsibility to show respect to stakeholders and the environment, slowing down in every step from design to shipping, and building a conscious and educated community. The paper has defined relevant terms and put forward the ground values of the sustainable fashion industry by giving a voice to sustainable clothing business owners, their experiences, and insights.
Congenital dyserythropoietic anemia type IV in the genetic era: A rare neonatal case report of rapid identification with a review of the literature
Authors: Deguise Marc‐Olivier , Blain Sarah , Simpson Ewurabena , Liebman Mira , Ferretti Emanuela 
Published: February 2023

AbstractCongenital dyserythropoietic anemia type IV (CDAIV) is a rare inherited hematological disorder, presenting with severe anemia due to altered erythropoiesis and hemolysis, with variable needs for recurrent transfusions. We present a case of a transfusion‐dependent male newborn who presented at birth with severe hemolytic anemia, and required an intrauterine transfusion. Genetic testing rapidly identified a Kruppel‐like factor 1 (KLF1) pathogenic variant (c.973G>A, p.E325K), known to be causative for CDAIV. This case highlights the advantages of next‐generation sequencing testing for congenital hemolytic anemia: diagnostic speed, guidance on natural history, and optimized clinical management and anticipatory guidance for parents and clinicians. Additionally, we reviewed the literature for all CDAIV cases.
Emotional distress predicts palliative cancer care attitudes: The unique role of anger
Authors: Mossman Brenna , Perry Laura M. , Gerhart James I. , McLouth Laurie E. , Lewson Ashley B. , Hoerger Michael 
Published: February 2023

AbstractObjectiveAlthough palliative care can mitigate emotional distress, distressed patients may be less likely to engage in timely palliative care. This study aims to investigate the role of emotional distress in palliative care avoidance by examining the associations of anger, anxiety, and depression with palliative care attitudes.MethodsPatients (N = 454) with heterogeneous cancer diagnoses completed an online survey on emotional distress and palliative care attitudes. Emotional distress was measured using the Patient‐Reported Outcomes Measurement Information System anger, anxiety, and depression scales. The Palliative Care Attitudes Scale was used to measure palliative care attitudes. Regression models tested the impact of a composite emotional distress score calculated from all three symptom measures, as well as individual anger, anxiety, and depression scores, on palliative care attitudes. All models controlled for relevant demographic and clinical covariates.ResultsRegression results revealed that patients who were more emotionally distressed had less favorable attitudes toward palliative care (p < 0.001). In particular, patients who were angrier had less favorable attitudes toward palliative care (p = 0.013) while accounting for depression, anxiety, and covariates. Across analyses, women had more favorable attitudes toward palliative care than men, especially with regard to beliefs about palliative care effectiveness.ConclusionsAnger is a key element of emotional distress and may lead patients to be more reluctant toward timely utilization of palliative care. Although psycho‐oncology studies routinely assess depression or anxiety, more attention to anger is warranted. More research is needed on how best to address anger and increase timely utilization of palliative cancer care.