bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single‐filament imaging mass spectrometry lipidomics in Arthrospira platensis
Authors: Lesco Kaitlin C. , Rowland Steven M. , Ratanathanawongs Williams S. Kim , Laurens Lieve M. L. 
Published: April 2023

RationaleElucidating intra‐organismal biochemical and lipid organization in photosynthetic biological cell factories of filamentous cyanobacteria, such as Arthrospira platensis (Spirulina), is important for tracking physiological response mechanisms during growth. Little is known about the filaments' biochemical organization and cellular structure and no label‐free imaging techniques exist that provide molecular mapping.MethodsWe applied ultrahigh‐resolution mass spectrometry (MS) with matrix‐assisted laser desorption ionization (MALDI) imaging to immobilized Spirulina filaments to investigate the localization of lipids across distinct physiological regions. We optimized matrix selection and deposition methods with the goal of facilitating high spatial, and intra‐filament, resolution using untargeted multivariate statistical spectral deconvolution across MS pixels.ResultsOur results demonstrate an improved two‐step matrix application with an optimized procedure for intra‐organismal lipid profiling to improve analyte sensitivity and achieve higher spatial resolution. We evaluate several conventional matrices, namely 2,5‐dihydroxybenzoic acid (DHB), superDHB (sDHB), 1,5‐diaminonaphthalene (DAN), and a 50:50 mix of DHB and sDHB, and compare delineation and pixel‐based elucidation of intra‐filament lipidomics. We identified a total of 1626 features that could be putatively assigned a lipid‐like formula based on database query and 46 unique features, with associated lipid assignments that were significantly distinct in their intra‐filament location.ConclusionsMALDI imaging MS with untargeted statistical spectral deconvolution was used to visualize intra‐filament lipidomics organization in Spirulina filaments. Improvements in matrix deposition, including sequential sublimation and pneumatic spraying, increased signal abundance at high spatial resolution and allowed for identification of distinct lipid composition regions. This work outlines a methodology that may be used for micro‐ecological untargeted molecular phenotyping.
Malignant neoplasm of lacrimal gland with pulmonary metastasis
Authors: Lewis Victoria , Sutton Kate , Davies Helen 
Published: April 2023

AbstractAdenoid cystic carcinomas (ACC) make up 3%–5% of head and neck malignancies. They have a high propensity to metastasise, in particular to the lungs. A 65‐year‐old male diagnosed with a right lacrimal gland ACC T2N0M0 (surgically resected 12 years prior) presented with an incidentally noted 1.2 cm right lower lobe lung nodule seen on MRI liver. Subsequent imaging confirmed a non‐FDG avid 1.6 cm solitary ovoid subpleural lesion, percutaneous biopsy confirmed adenocarcinoma. A surgical metastasectomy was performed and recovery was complete. Prognosis in ACC is improved with radical management of metastatic disease. Rather than a simple chest radiograph, more detailed imaging, such as MRI or CT scanning may increase the probability of early detection of pulmonary metastasis and, thereby facilitate radical treatment and improve survival.
Programmable DNA Hydrogel Provides Suitable Microenvironment for Enhancing TSPCS Therapy in Healing of Tendinopathy
Authors: Ge Zilu , Li Wei , Zhao Renliang , Xiong Wei , Wang Dong , Tang Yunfeng , Fang Qian , Deng Xiangtian , Zhang Zhen , Zhou Yaojia , Chen Xiaoting , Li Yue , Lu Yanrong , Wang Chengshi , Wang Guanglin 
Published: April 2023

AbstractTendon stem/progenitor cells (TSPCs) therapy is a promising strategy for enhancing cell matrix and collagen synthesis, and regulating the metabolism of the tendon microenvironment during tendon injury repair. Nevertheless, the barren microenvironment and gliding shear of tendon cause insufficient nutrition supply, damage, and aggregation of injected TSPCs around tendon tissues, which severely hinders their clinical application in tendinopathy. In this study, a TSPCs delivery system is developed by encapsulating TSPCs within a DNA hydrogel (TSPCs‐Gel) as the DNA hydrogel offers an excellent artificial extracellular matrix (ECM) microenvironment by providing nutrition for proliferation and protection against shear forces. This delivery method restricts TSPCs to the tendons, significantly extending their retention time. It is also found that TSPCs‐Gel injections can promote the healing of rat tendinopathy in vivo, where cross‐sectional area and load to failure of injured tendons in rats are significantly improved compared to the free TSPCs treatment group at 8 weeks. Furthermore, the potential healing mechanism of TSPCs‐Gel is investigated by RNA‐sequencing to identify a series of potential gene and signaling pathway targets for further clinical treatment strategies. These findings suggest the potential pathways of using DNA hydrogels as artificial ECMs to promote cell proliferation and protect TSPCs in TSPC therapy.
Integration of Metal–Organic Frameworks and Metals: Synergy for Electrocatalysis
Authors: Hu Yue , Liu Jiawei , Lee Carmen , Li Meng , Han Bin , Wu Tianci , Pan Hongge , Geng Dongsheng , Yan Qingyu 
Published: April 2023

AbstractElectrocatalysis is a highly promising technology widely used in clean energy conversion. There is a continuing need to develop advanced electrocatalysts to catalyze the critical electrochemical reactions. Integrating metal active species, including various metal nanostructures (NSs) and atomically dispersed metal sites (ADMSs), into metal–organic frameworks (MOFs) leads to the formation of promising heterogeneous electrocatalysts that take advantage of both components. Among them, MOFs can provide support and protection for the active sites on guest metals, and the resulting host‐guest interactions can synergistically enhance the electrocatalytic performance. In this review, three key concerns on MOF‐metal heterogeneous electrocatalysts regarding the catalytic sites, conductivity, and catalytic stability are first presented. Then, rational integration strategies of MOFs and metals, including the integration of metal NSs via surface anchoring, space confining, and MOF coating, as well as the integration of ADMSs either with the metal nodes/linkers or within the pores of MOFs, along with their recent progress on synergistic cooperation for specific electrochemical reactions are summarized. Finally, current challenges and possible solutions in applying these increasingly concerned electrocatalysts are also provided.
Enhanced Interfacial Charge Transfer/Separation By LSPR‐Induced Defective Semiconductor Toward High Co2RR Performance
Authors: Jiang Jingwen , Wang Xiaofeng , Guo Hong 
Published: April 2023

AbstractSolar‐driven reduction of CO2 emissions into high‐value‐added carbonaceous compounds has been recognized as a sustainable energy conversion way. The high‐efficiency charge separation and effective activation are the critical issues in the process. The local plasma effect of metal and the vacancy of semiconductors in the metal‐semiconductor heterostructure can solve this issue extensively. Herein, an oxygen vacancy photocatalyst containing uniform Ag nanoparticles (Ag‐20@Nb2O5‐x) is designed, which exhibits an excellent reduction performance and the CO yield can reach 59.13 µmol g−1 with high selectivity. The carrier migration is accelerated and the activation of CO2 is facilitated by the local surface plasmon effect and oxygen vacancy. Moreover, the photocatalytic CO2 reduction mechanism is revealed based on the density functional theory and in situ technology in detail. This work provides an in‐depth understanding of the design of more ingenious metal‐semiconductor photocatalysts to achieve more efficient charge transfer.
Mixed ion‐electron conducting Li3P for efficient cathode prelithiation of all‐solid‐state Li‐ion batteries
Authors: Li Jing , Liu Dan , Sun Han , Qu Deyu , Xie Zhizhong , Tang Haolin , Liu Jinping 
Published: April 2023

AbstractAll‐solid‐state batteries (ASSBs) using sulfide electrolytes hold promise for next‐generation battery technology. Although using a pure Li metal anode is believed to maximize battery energy density, numerous recent studies have implicated that Li‐ion anodes (e.g., graphite and Si) are more realistic candidates due to their interfacial compatibility with sulfide electrolytes. However, those Li‐ion ASSBs suffer from an issue similar to liquid Li‐ion batteries, which is a loss of active Li inventory owing to interfacial side reactions between electrode components, resulting in reduced available capacities and shortened cycle life. Herein, for the first time, we explore the potential of Li3P for cathode prelithiation of Li‐ion ASSBs. We identify that the crystallized Li3P (c‐Li3P) has room‐temperature ionic and electronic conductivities of both over 10−4 S/cm. Such a mixed ion‐electron conducting feature ensures that the neat c‐Li3P affords a high Li+‐releasing capacity of 983 mAh/g in ASSBs during the first charging. Moreover, the electrochemical delithiation of c‐Li3P takes place below 2 V versus Li+/Li, while its lithiation dominates below 1 V versus Li+/Li. Once used as a cathode prelithiation regent for ASSBs, c‐Li3P only functions as a Li+ donor without lithiation activity and can adequately compensate for the Li loss with minimal dosage added. Besides mitigating first‐cycle Li loss, c‐Li3P prelithiation can also improve the battery cyclability by sustained release of low‐dosage Li+ ions in subsequent cycles, which have been embodied in several full ASSBs by coupling a LiCoO2 cathode with various types of anodes (including graphite, in foil, Sb, and Si anode). Our work provides a universal cathode prelithiation strategy for high‐efficiency Li‐ion ASSBs.
Sequentially bridged MXene platelets for strong high‐temperature EM‐IR bi‐stealth sheets
Authors: Yang Yushan , Chen Kaicong , Chen Yipeng , Wang Chao , Dang Baokang , Li Yingying , Liu Ming , Sun Qingfeng 
Published: April 2023

AbstractCombination of flexible multifunctional stealth technology properties such as electromagnetic (EM) and infrared (IR) stealth is crucial to the development of aerospace, military, and electronic fields, but the synthesis technology still has a significant challenge. Herein, we have successfully designed and synthesized highly flexible MXene@cellulose lamellae/borate ion (MXCB) sheets with strong high‐temperature EM‐IR bi‐stealth through sequential bridging of hydrogen and covalent bonds. The resultant MXCB sheets display high conductivity and good mechanical features such as flexibility, stretchability, fatigue resistance, and ultrasonic damage. MXCB sheets have a high tensile strength of 795 MPa. Furthermore, MXCB sheets with different thicknesses indicate exceptional high‐temperature thermal‐camouflage characteristics. This reduces the radiation temperature of the target object (>300 °C) to 100 °C. The conductivity of MXCB sheet with 3 μm thickness is 6108 S/cm and the EM interference (EMI) shielding value is 39.74 dB. The normalized surface‐specific EMI SE absolute shielding effectiveness (SSE/t) is as high as 39312.78 dB·cm2/g, which remained 99.39% even after 10,000 times repeated folding. These multifunctional ultrathin MXCB sheets can be arranged by vacuum‐assisted induction to develop EM‐IR bi‐stealth sheet.
Multidimensional landscape of non‐alcoholic fatty liver disease‐related disease spectrum uncovered by big omics data: Profiling evidence and new perspectives
Authors: Zhu Zhengyi , Chen Yuyan , Qin Xueqian , Liu Shujun , Wang Jinglin , Ren Haozhen 
Published: April 2023

AbstractCharacterized by hepatic lipid accumulation, non‐alcoholic fatty liver disease (NAFLD) is a multifactorial metabolic disorder that could promote the progression of non‐alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). Benefiting from recent advances in omics technologies, such as high‐throughput sequencing, voluminous profiling data in HCC‐integrated molecular science into clinical medicine helped clinicians with rational guidance for treatments. In this review, we conclude the majority of publicly available omics data on the NAFLD‐related disease spectrum and bring up new insights to inspire next‐generation therapeutics against this increasingly prevalent disease spectrum in the post‐genomic era.
Guinea Grass Seed (Megathyrsus maximus), a Potential Novel Starch Source: Impact of Isolation Methods on Functional, Morphological, Structural, Pasting, and Rheological Properties
Authors: Bist Yograj , Sharanagat Vijay Singh , Saxena Dharmesh C. 
Published: April 2023

AbstractIn the present study, Guinea seed starch (GS) is extracted using four different isolation methods (Sodium hydroxide [NaOH], potassium metabisulphite [KMS], citric acid [CA], and distilled water [DW]) to investigate the effect of isolation methods on different properties of starch. The water and oil absorption capacity range from 0.69 to 1.12 g g−1and 0.81 to 0.95 g g−1, respectively. The swelling and solubility of isolated starches are temperature dependent and increase with temperature (70–90 °C). The amylose content also varies with isolation method and all the starch showed typical A‐type X‐ray patterns. The mean particle size of GS is 9.86–13.36 µm and shows round to polygonal shapes with pores. The isolation method impacts glass transition temperatures and enthalpies, which vary between 73.36–83.67 °C and 0.72–23.69 J g−1, respectively. The pasting temperature (PT) also varies with the isolation method and follows the pattern of CA (84.80 ± 0.07 °C) > KMS (81.97 ± 0.06 °C) > DW (81.95 ± 0.05 °C) > NaOH (79.82 ± 0.03 °C). All the starches showed shear thinning behavior, and storage modulus is higher than loss modulus, representing that the elastic component is higher than the viscous component.
Eriocaulaceae: A new classification system based on morphological evolution and molecular evidence
Authors: Andrino Caroline Oliveira , Costa Fabiane Nepomuceno , Simon Marcelo Fragomeni , Missagia Rafaela Velloso , Sano Paulo Takeo 
Published: April 2023

AbstractPaepalanthus, in its current sense, is the most diverse genus of Eriocaulaceae in the Neotropics, comprising about 400 species. Previous studies have consistently found that the genus is not monophyletic, also being morphologically heterogeneous and diagnosable by a set of homoplasies; thus, the current circumscription needs to be revised. The new classification proposed here uses a comprehensive phylogeny of Paepalanthus and closely related genera as a framework and an evaluation of a set of morphological characters using ancestral state reconstruction, which allowed the recognition of strongly supported clades with morphological diagnosability. We propose the recognition of 12 genera in the clade encompassing Paepalanthus and allied groups, including six new genera (Coracoralina, Floralia, Giuliettia, Gnomus, Hydriade, Nisius), two new statuses (Cryptanthella, Monosperma), the reestablishment of Actinocephalus, Lachnocaulon, and Tonina, and a recircumscription of Paepalanthus. In this new circumscription, Paepalanthus comprises 257 species, most of them restricted to the Brazilian campos rupestres. Among the proposed genera, nine have potential morphological synapomorphies, one has a restricted geographical distribution, and the other two can be recognized by a combination of characters. Newly generated seed morphology data is consistent within the different genera and plays an important role in their recognition. A total of 136 new combinations are hereby proposed. We provide a genus‐level identification key, as well as generic descriptions, diagnostic features, photos illustrating their morphological diversity, maps and notes on distribution, and lists of species by genus.
Analysis of Coronado State Historic Site artifacts using X‐rays
Authors: Young Steven G. , Valdez James , Espy Michelle , Edgar Alex , Brett Jack , Pettes Michael T. , Mathers Clay , Barbour Matthew , Patterson Brian M. 
Published: April 2023

AbstractTwo historic‐period metal artifacts were provided by the New Mexico Historic Sites to Los Alamos National Laboratory for non‐destructive analysis. The artifacts were a crossbow quarrel (or bolthead) and a reliquary pendant recovered from Kuaua Pueblo (also known as the Coronado Historic Site) in Bernalillo, NM. The quarrel is a heavily patinated metal that had been flattened due to compressive forces. The pendant consisted of a metal casing that had previously surrounded two center gemstones on the front and rear face of the pendant. The gemstone in the rear setting had fractured and was displaced from the setting, leaving only a small, loose fragment within the pendant for study. The front gem appeared to be very dark, near‐black in color, and the fragment of the rear gem was a bright red color. The artifacts were analyzed to ascertain their composition and glean insight into their provenance using the following X‐ray techniques: X‐ray computed tomography, confocal micro X‐ray fluorescence, and X‐ray diffraction. Infrared spectroscopy and electron microscopy were used on selected areas. Ultraviolet Raman spectra were collected on the two gems and the pendant. The metal material of the artifacts was found to be primarily composed of copper. The gems in the pendant were composed of manganese (front gem) and calcium (side gem).
Propagation of two Rayleigh waves in viscoelastic medium: Explicit expressions for complex velocities
Authors: Sharma Mohan D 
Published: April 2023

AbstractPropagation of Rayleigh waves is considered in an isotropic linear viscoelastic medium. Such propagation is represented through a complex velocity, which lies implicit in an irrational secular equation. A complex analysis technique is used to transform this irrational complex equation into an algebraic equation. A linear equation replaces the secular equation for propagation of the classical Rayleigh wave in viscoelastic medium. A quadratic equation replaces the secular equation for propagation of additional Rayleigh wave, which exists for appropriate value of a complex parameter. Explicit expressions are obtained for the complex velocity, which satisfy the secular equation for Rayleigh waves. Two different analytical expressions for the velocity certify the existence of second Rayleigh wave in some viscoelastic materials with specifically related elastic and dissipative parameters. Numerical examples are solved to analyse the complex velocities and particle motion for the two Rayleigh waves in viscoelastic materials.
Was ist Inflation (und wie misst man sie)?
Authors: Gischer Horst , Herz Bernhard , Menkhoff Lukas 
Published: April 2023

ZusammenfassungMit der Inflation wird das Geld entwertet, weil man für denselben Geldbetrag weniger Güter oder Dienstleistungen kaufen kann. Dies können alle Verbraucher:innen direkt spüren, wenn sie Güter regelmäßig kaufen, deren Preise sie gut kennen, und diese dann steigen. Als Beispiel mag ein Liter Milch gelten, ein Pfund Butter oder andere Standardprodukte.
Laborchemisches und kalorimetrisches Monitoring der medizinischen Ernährungstherapie auf der Intensiv- und Intermediate Care Station
Authors: Elke Gunnar , Hartl Wolfgang H. , Adolph Michael , Angstwurm Matthias , Brunkhorst Frank M. , Edel Andreas , Heer Geraldine de , Felbinger Thomas W. , Goeters Christiane , Hill Aileen , Kreymann K. Georg , Mayer Konstantin , Ockenga Johann , Petros Sirak , Rümelin Andreas , Schaller Stefan J. , Schneider Andrea , Stoppe Christian , Weimann Arved 
Published: April 2023

ZusammenfassungDieses zweite Positionspapier der Sektion Metabolismus und Ernährung der Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin (DIVI) gibt Empfehlungen zum laborchemischen Monitoring der Makro- und Mikronährstoffzufuhr sowie zum Einsatz der indirekten Kalorimetrie im Rahmen der medizinischen Ernährungstherapie erwachsener Intensivpatient:innen. Zusätzlich werden Empfehlungen zur krankheitsbezogenen bzw. individuellen (Spiegelbestimmung) Substitution und (Hochdosis‑)Pharmakotherapie von Vitaminen und Spurenelementen vorgenommen.
Implications of BCRP modulation on PTZ-induced seizures in mice: Role of ko143 and metformin as adjuvants to lamotrigine
Authors: Harby Sahar A. , Khalil Nehal A. , El-Sayed Norhan S. , Thabet Eman H. , Saleh Samar R. , Fathelbab Mona Hassan 
Published: April 2023

AbstractBlood–brain barrier (BBB) efflux transporters' overexpression hinders antiepileptic drug brain entry. Breast cancer resistance protein (BCRP) is a major BBB efflux transporter. In the present work, BCRP's role as a mechanism that might contribute to drug-resistant epilepsy (DRE) in a mouse model of acute seizures was studied with further assessment of the effect of its inhibition by ko143 and metformin (MET) on lamotrigine (LTG) bioavailability and efficacy. 42 male mice divided into 6 groups: G1: Normal control, G2: LTG-injected healthy mice: LTG 20 mg/kg i.p., G3: Acute seizures (A.S) mice: Pentylenetetrazole (PTZ) 50 mg/kg i.p., G4: LTG-treated A.S mice: LTG 20 mg/kg + PTZ 50 mg/kg i.p., G5: Ko143 + LTG treated A.S mice: Ko143 15 mg/kg i.p. before LTG + PTZ, G6: MET + LTG treated A.S mice: MET 200 mg/kg i.p. before LTG + PTZ. Seizures severity, serum, brain LTG, and brain BCRP were assessed. PTZ group experienced the highest seizure frequency and brain BCRP expression. Ko143 and MET groups showed a significant decrease in brain BCRP with subsequent improvement in brain LTG level and better seizure control. BCRP has a significant role in epilepsy resistance and its inhibition with ko143 or MET adds value to DRE management.
How the timing of visual feedback influences goal-directed arm movements: delays and presentation rates
Authors: Brenner Eli , van Straaten Chris A. G. , de Vries A. Julia , Baas Tobias R. D. , Bröring Kirsten M. , Smeets Jeroen B. J. 
Published: April 2023

AbstractVisual feedback normally helps guide movements to their goal. When moving one’s hand, such guidance has to deal with a sensorimotor delay of about 100 ms. When moving a cursor, it also has to deal with a delay of tens of milliseconds that arises between the hand moving the mouse and the cursor moving on the screen. Moreover, the cursor is presented at a certain rate, so only positions corresponding with the position of the mouse at certain moments are presented. How does the additional delay and the rate at which cursor positions are updated influence how well the cursor can be guided to the goal? We asked participants to move a cursor to consecutive targets as quickly as they could. They did so for various additional delays and presentation rates. It took longer for the mouse to reach the target when the additional delay was longer. It also took longer when a lower presentation rate was achieved by not presenting the cursor all the time. The fraction of the time during which the cursor was present was more important than the rate at which the cursor’s position was updated. We conclude that the way human arm movements are guided benefits from continuous access to recent visual feedback.
Modifications of simple models of polymer blend compatibilization using block copolymer
Authors: Fortelný Ivan , Jůza Josef 
Published: April 2023

AbstractPolymer blends can be compatibilized using block and graft copolymers with blocks identical to, miscible with, or adhering to related components of the blend. The relatively simple models of compatibilized blends published in our preceding papers following up on the work of Leibler and its modification by Retsos, based on the comments of Noolandi, have now been extended. Our analysis of the mean field formula for a decrease in the interfacial tension by Noolandi and Hong resulted in further modification. This modification provides a higher amount of copolymer in the interfacial region and higher compatibilization efficiency than models used in our previous papers. In contrast to previous theories, it predicts maximum compatibilization efficiency for copolymer blocks somewhat shorter than the homopolymers. With respect to the Flory–Huggins interaction parameter, this calculated maximum reaches its lowest value for a certain value of the interaction parameter.