bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empirical likelihood and estimation in single-index varying-coefficient models with censored data
Authors: Xue Liugen 
Published: January 2023

Abstract
In this paper, we investigate the empirical likelihood and estimation of parameters of interest in single-index varying coefficient models with right censored data. A bias-corrected empirical log-likelihood ratio statistic for the regression parameter is proposed. It is shown the the statistic is asymptotically standard chi-squared, and thus the confidence region of the regression parameter is constructed. The estimators for both the regression parameter and the coefficient functions are constructed, their asymptotic distributions are obtained, and the consistent estimators for the asymptotic variances are given. The obtained results can be directly used to construct the confidence regions of the regression parameter and the pointwise confidence intervals of the coefficient functions. Our approach is to directly calibrate the empirical log-likelihood ratio, so that the resulting ratio is asymptotically chi-squared, un-dersmoothing of the coefficient functions is avoided, and the existing data-driven methods can effectively select the optimal bandwidth. The finite-sample behavior of the new methods is evaluated through simulation studies, and applications to a real data are illustrated.
Nulcearity for power series kernels on higher dimensions
Authors: Delgado Julio , Posada Liliana 
Published: January 2023

Abstract
In this work we establish the nuclearity on Lebesgue spaces for a class of power series kernels in higher dimensions. This class includes important examples arising as Maclaurin series kernels as well as the Fox-Li and related operators. As a consequence we derive the rate of decay of the corresponding eigenvalues and trace formulae.
2020 Mathematics Subject Classification. Primary 47B35; Secondary 47C05, 47B06, 45C05
Application of Magnetic Drag Force in Hybridization of Ag-Cu/Blood flow in a Stenosed Arterial System in Darcian Porous Material: A Finite Difference Scheme
Authors: Ahmed Karishma Karam , Ahmed Sahin 
Published: January 2023

Abstract
The present article investigates on a hybrid nano-fluid blood flow in an artery having stenosis under the existence of an external magnetic field over a porous medium via numerical approach. Hybridization of silver and copper with blood as the base fluid is taken into consideration. The governing equations of the blood flow model are patterned into partial differential equations which are converted to sets of ordinary differential equation with the assistance of similarity transformation. The primary features of the MHD arterial flow of blood over the porous surface are represented distinctly by representation of the dual solutions acquired for Velocity and fluid Temperature. The impacts of the variables of the bio-fluid with various parameters like Flow parameter (γ), Porosity parameter (Kp), Magnetic drag force (M), Prandtl Number (Pr), Volume fraction of Silver (Φ1) and Volume fraction of Copper (Φ2) are illustrated and explained in detail through graphs using bvp4c solver in MATLAB Software. Numerical overviews of the evaluated results are compared with numerical study of another published earlier in scientific literatures. This study is beneficial in hyperthermia treatments, vasoconstriction phenomenon, lipolysis, nanotechnology-based drug delivery systems, pulsatile flow analysis and movement of simple flow.
Few-shot Partial Multi-label Learning with Synthetic Features Network
Authors: Sun Yifan , Zhao Yunfeng , Yu Guoxian , Yan Zhongmin , Domeniconi Carlotta 
Published: January 2023

Abstract
In partial multi-label learning (PML) problems, each training sample is partially annotated with a candidate label set, among which only a subset of labels are valid. The major hardship for PML is that its training procedure is prone to be misled by false positive labels concealed in the candidate label set. To train a noise-robust multi-label predictor for PML problem, most existing methods hold the assumption that sufficient training samples are available. However, in actual fact, especially when dealing with new tasks, we more often only have a few PML samples for the target task. In this paper, we propose a unified model called FsPML-SF (Few-shot Partial Multi-Label Learning with Synthetic Features Network). FsPML-SF includes three modules: label disambiguation, data augmentation and classifier induction. Specifically, FsPML-SF attempts to update the label credibility of each PML sample by leveraging the feature and semantic similarities, the label credibility of other samples and label co-occurrence in a unified objective function. Next, FsPML-SF introduces a synthetic feature network to generate more training samples from pairs of given samples with corresponding label credibility values. FsPML-SF then utilizes the original and synthesized samples to induce a noise-tolerant multi-label classifier. We conducted extensive experiments on benchmark datasets, FsPML-SF outperforms recent competitive PML baselines and few-shot solutions. Both the label denoising and data augmentation improve the performance of PML on few-shot data.
Women, technology, and water: creating new waterscapes and contesting cultural norms
Authors: Sarkar Anindita 
Published: January 2023

Abstract
With the analysis of primary data, the paper looks at how the adoption of new modes of water technologies and subsequent water commercialization has created new waterscapes. Water commercialization is changing cultural norms associated with water collection in the drought-prone villages of western Rajasthan. The newly introduced water tankers have selectively benefited the upper caste rich households who now buy water from the tankers at doorsteps. The majority of the poor and low caste households remain dependent on common water sources that are drying up due to neglect with the advent of water commercialization. Women from low caste poor households have to walk for long distances to fetch water in addition to doing physical labor to support family income. Though domestic water use remains a domain of woman's working space, men from high caste rich households have started fetching and storing water as it entails cash transactions.
The Association of LDH Expression and Delayed Cerebral Ischemia in
Patients with Aneurysmal Subarachnoid Hemorrhage: Possible Involvement
of Cerebral Blood Perfusion
Authors: Sun Xiaochuan , Wu Yue , Wang Yingwen , Tang Shuang , Yang Xiaomin , Cao Yunchuan , Li Xiaoguo , Xu Rui , Yan Jin , Guo Zongduo 
Published: January 2023

Background and Purpose:
Several pieces of evidence suggest that serum lactate hydrogenase
(LDH) level is associated with the pathological process of delayed cerebral ischemia (DCI)
after aneurysmal subarachnoid hemorrhage (aSAH). This research aimed to investigate the associations
of serum LDH level with the occurrence of DCI in aSAH patients.

Methods:
A total of 122 patients diagnosed with aSAH within 72h of onset were retrospectively
enrolled. The serum levels of LDH between 7:00-8:00 am on day 1, day 3 and day 7, patients’ demographics,
and clinical features were collected. Computed tomography perfusion was performed
within 7 days after aSAH. The occurrence of DCI was recorded during the hospitalization.

Results:
Among all the enrolled patients, 43 (35.2%) developed DCI during hospitalization. Patients
occurred DCI were always accompanied by more serious clinical features and found with higher
serum LDH levels. LDH levels on day 3 and day 7 after onset were independently associated with
the occurrence of DCI and showed high predictive value according to the receiver operating characteristic
(ROC) curve. Moreover, there was a strong correlation between LDH and mean cerebral
blood flow, transit time, and mean time to peak.

Conclusions:
Serum LDH level on day 3 and day 7 may be a valuable, convenient, and rapid predictive
indicator for the occurrence of DCI in aSAH patients.
Hetero Cyclic Compounds in the Treatment of Triple-Negative Breast Cancer
Authors: Rath Santosh Kumar , Mandal Sudip Kumar , Das Agnidipta , Bose Anindya , Dwibedi Vagish , Ganguly Paramita , Sarkar Sipra , Prakash Ranjana , Dey Biplab Kumar , Mandal Sanjeet 
Published: January 2023

Abstract:Triple-negative breast cancer (TNBC) holds just about 15% of all breast tumours and subtypes of breast cancer with distinct characteristics of negative expressions for the progesterone receptor, estrogen receptor, and human epidermal growth factor receptor 2. Unfortunately, treatment options for TNBCs are minimal. Most currently available therapies proved inefficient in holding back this aggressive natural treatment of TNBC, in most cases calling for an immediate need for more effective and safer anti-TNBC agents. Based on research reported in recent years, this review presents the report's overview of anti-TNBC compounds and their efficacy, being classified according to the structures. Breast Cancer type 1 and type 2 genes (BRCA1/2) mutations are associated with TNBC. Poly (ADP-Ribose) Polymerases (PARPs) are a family of enzymes involved in numerous cellular processes, including DNA repair. PARP-1 inhibition is involved in the loss of DNA repair via BRCA-dependent mechanisms. PARP-1 inhibitors like Olaparib, Rucaparib, Niraparib, and Talazoparib have proved as promising therapeutic medications as monotherapy and in combination with cytotoxic therapy or radiotherapy in various types of cancers. This review is focused on presenting the status of therapeutics against TNBC. The critical spotlight of this review is to encapsulate the versatility and notable success of heterocyclic pharmacophores-based molecules in treating TNBC.
Comparing Responses of Ursolic Acid in Murine Macrophages Infected with Mycobacterium smegmatis and Mycobacterium avium
Authors: Pitaloka Dian , Jihadah Muti’ah Nurul 
Published: January 2023

Mycobacterium smegmatis and Mycobacterium avium offer an advantage in examining tuberculosis-like effects and host immune defense. Therefore, the study aims to examine the effect of ursolic acid (UA) on the host immune system by analyzing cytokines concentration, such as TNF-α, IL-6, IL-1β, and nitrite oxide produced by murine macrophages infected with Mycobacterium smegmatis and Mycobacterium avium. Femurs of female C57BL/6 mice aged 6–8 weeks were used to culture the Bone marrow-derived macrophages (BMDM). On day 10, BMDM was infected with Mycobacterium smegmatis and Mycobacterium avium using a multiplicity of infection (MOI) amounting to 8:1, then TNF-α, IL-6, and IL-1β were analyzed using ELISA and nitrite oxide with Griess reagent. The results showed that UA decreased the production of three respective pro-inflammatory cytokines used in the study, both in BMDM infected by Mycobacterium smegmatis and Mycobacterium avium. For TNF-α, the reduction was nearly 65%-90% compared to the control. The decrease in the production of IL-6 occurred from 2700 pg/ml to 750 pg/ml for BMDM infected with Mycobacterium smegmatis, while the reduction was more significant in those infected using Mycobacterium avium with approximately 150 pg/ml compared to the control. Moreover, UA reduced by over 90% of IL-1β and this result was in line with the reduction of nitrite. UA decreases the production of pro-inflammatory cytokines such as TNF-α, IL-6, IL-1β, and nitrite. This result is preliminary but supports further study on the role of UA in immune defense from pathogenic and non-pathogenic mycobacterial infections.
Evaluation of Current Practice of Antibiotic Use and Clinical Outcomes of Community-Acquired Pneumonia Patients with Type 2 Diabetes Mellitus in Indonesia
Authors: Ariyanti Desi , Sauriasari Rani , Yunir Em 
Published: January 2023

Impaired immunity in diabetes mellitus (DM) causes reduced lung function, which increases the incidence of various types of infections, including community-acquired pneumonia (CAP). The main principle of CAP therapy is the administration of antibiotics. This study aims to assess the appropriate use of antibiotics according to existing clinical practice guidelines using the Gyssen algorithm, and to determine its effect on clinical outcomest in hospitalized patients. It is an observational study with a retrospective cohort design and total sampling technique. The research was conducted at Dr. Cipto Mangunkusumo Hospital Jakarta, with the research subjects being 98 hospitalized CAP patients with type 2 DM (T2DM) over the period January 2018 - December 2019. The collection of data on patient characteristics and clinical outcomes was made through patient medical records. 28.6% of the subjects were in the severe category of CAP. The results of the evaluation using the Gyssen algorithm showed that 59.2% of the subjects receive the appropriate antibiotics, while 40.8% receive non appropriate antibiotics. The clinical outcomes in the group receiving appropriate antibiotics (70.7%) was significantly higher than the non-appropriate group (42.5%). The results of the multivariate analysis show that the group receiving appropriate antibiotics experienced 2.7 times greater clinical outcomes (RR 2.683, 95% CI: 1.102-6.592), after controlling for the degree of CAP and the onset of antibiotic administration. The use of appropriate antibiotics in CAP patients with T2DM significantly enhanced clinical outcomes.
An Investigation on The Use of Colistin in Critically Ill Patients at A Teaching Hospital in Ho Chi Minh City
Authors: Vu Thi Lan Nhi , Dang Nguyen Doan Trang , Nguyen Tu Thien Tam 
Published: January 2023

Colistin is reintroduced into therapeutic protocols as one of the last resort antibiotics against multidrug-resistant (MDR) pathogens. In February 2019, the International Consensus Guidelines (ICG 2019) on optimizing the administration of colistin has for the first time stipulated an official recommendation for higher colistin dosing regimen based on pharmacokinetic/pharmacodynamic (PK/PD) modeling data. This study aimed at assessing the current dosing of colistin at University Medical Center (UMC) of Ho Chi Minh City (HCMC) and to identify rates and risk factors of colistin-induced nephrotoxicity. A cross sectional study was conducted on patients admitted to Intensive Care Unit (ICU), being treated for severe infection with at least 5 days of colistin IV administration from April 2018 to April 2019. KDIGO criteria were used to evaluate nephrotoxicity during treatment. Colistin-resistance was detected in 4 cases during the study period. The majority (n=104, 87.4%) of patients was diagnosed with pneumonia due to mainly Acinetobacter baumannii. Rational dosing according to PK/PD approach, EMA, FDA was observed in 33 cases (27.8%), 39 cases (32,8%), and 44 cases (38,2%), respectively. 85 cases (71,4%) were evaluated as rational dosing in accordance with at least one of the three guidelines. Clinical efficacy was recorded in 59 infected patients (49.6%). Lower average maintenance dose was observed in patients with treatment failure (p = 0.002). KDIGO-defined acute kidney injury (AKI) developed in 70 patients (58,8%). Multivariate analysis showed that concomitant administration of vasopressors (OR = 16.52; 95% CI 5.3750.83; p = 0.001), furosemide (OR = 5.24; 95% CI 1.89–14.55; p = 0.001) and hypoalbuminemia (< 25 g/l) (OR = 6.24; 95% CI 2.17–17.93; p = 0.001) were significantly associated with nephrotoxicity. Consistent with previous studies, due to a very modest clinical cure rate with a high frequency of colistin-induced AKI and the development of colistin-resistant strains, alternative agents such as new beta-lactam/beta-lactamase inhibitor combinations with favourable safety data are strongly preferred for the treatment of carbapenem-resistant infection.
Synthesis and Antioxidant Actiivty of Some Dibenzylidene-Cyclohexanones
Authors: Ritmaleni Ritmaleni , Fatmayanti Risma Baiq , Ekananda Shinta Diva , Tranggono Bhagaskara Naufal , Arsani Nanda Kurnia , Rumiyati Rumiyati 
Published: January 2023

Dibenzylidene-cyclohexanone is a curcumin analog. Analog of curcumins showed activity as antioxidant. This research is aimed to synthesize and study the antioxidant activity of dibenzylidene-cyclohexanone compounds. The synthesis was carried out according to carbonyl condensation reaction and its antioxidant activity was tested by using DPPH radical scavenging activity and FRAP assay. Compound entry 1 (2,6-bis-(3’-Bromo-4’-methoxybenzylidene)-cyclohexanone) and entry 3 (2,6-bis-(2’-chloro-6’-fluorobenzylidene)- cyclohexanone) were obtained in 70 % yield. Compound entries 1 and 2 gave the same antioxidant activities according to the DPPH method and this result was not good enough compared to vitamin E. Compound entry 1 showed the best antioxidant activity among the series and also had a better antioxidant activity compared to vitamin E. From these results, it can be said that compound entry 1 was the best antioxidant agent in the series.
Peran Media Sosial dalam Membangun Kompetensi Literasi Sampah Generasi Muda di Kabupaten Sleman
Authors: Silaningrum Raras 
Published: January 2023

Permasalahan sampah di Daerah Istimewa Yogyakarta (DIY) tak kunjung usai, salah satunya dikarenakan masyarakat tidak menyadari masalah yang timbul dari sampah-sampah yang mereka hasilkan dalam jangka waktu panjang, terlihat dari ketidakpedulian mereka terhadap pengelolaan sampah masih tinggi. Media memegang peranan penting menginformasikan kepada publik mengenai hal tersebut, selain media, potensi lain pengentasan masalah sampah di DIY adalah pemuda sebagai aktor pembangunan. Kabupaten Sleman merupakan salah satu daerah yang menghasilkan sampah terbesar di DIY, namun demikian mereka juga memiliki pemuda dengan jumlah terbanyak yang dapat dilibatkan untuk mengentaskan masalah sampah. Fokus kajian ini yaitu menganalisis pengaruh peranan media sosial terhadap kompetensi literasi sampah generasi muda di Kabupaten Sleman. Jenis penelitian ini adalah deskriptif analisis dengan pendekatan kuantitatif survei. Lokasi penelitian berada di Kabupaten Sleman, populasinya adalah pemuda anggota karang taruna di Kabupaten Sleman. Hasil penelitian menunjukkan terdapat tiga jalur pengaruh positif peranan media sosial terhadap kompetensi literasi sampah yaitu jalur langsung tanpa perantara, jalur tidak langsung melalui sikap, dan jalur melalui pengetahuan dan sikap. Sementara itu, jalur tidak langsung melalui pengetahuan tidak terbukti signifikan. Hal ini dikarenakan pengetahuan yang dimiliki generasi muda tidak cukup komprehensif untuk merespons isu sampah. Berdasarkan tiga jalur pengaruh yang signifikan, jalur pengaruh langsung memiliki nilai korelasi yang paling kuat. Namun, peranan media sosial tersebut belum dirasakan secara optimal oleh generasi muda karena berada pada kategori kadang-kadang, sehingga pemanfaatannya masih perlu dioptimalkan.
DIALECTIC OF CANING PUNISHMENT IN ACEH: CONTESTATION BETWEEN TEXT AND CONTEXT
Authors: Yahya Faisal 
Published: January 2023

The field study was conducted to assess how the execution of caning punishment in prison or detention center has been implemented in Aceh based on Qur'an and hadith perspective. Responding to the aim of study, an interpretation and explanation of the verses of Qur'an and hadith was done related to the implementation of the caning punishment, while the field data obtained by interview and documentation. The result of the study indicated that the execution process of caning in prison or detention center does not meet the standards in Qur'an and hadith because the procession is carried out in a closed place (prison) and access to the prison is bounded by standard rules. So the caning punishment process should be carried out in public places that are accessible to the society.Keywords: Caning Punishment; Prison or Detention Center; Quranic, Hadith; Sharia Formal Application
Banking against Global Economic Crisis: Comparison of Covid-19 Pandemic and 2008 Recession
Authors: Ferranti Putri Andari , Rosdiana Riska , Raharja Indra 
Published: January 2023

In the last twenty years, there has been two major global economic crises in Indonesia with very different origin, the 2008 global financial crisis was induced by failure of international banks while the 2020 global pandemic crisis was induced by economic slowdown due to worldwide infectious disease. Previous researches implied that the financial crisis had more tendency to deplete capital without slowing down credit distribution thus facing bigger risk of illiquidity while it had the opposite effect on the pandemic crisis where banks withhold their capital too much and distributed too little leading to less profitability. We found that the persistence of changes of CAR, LDR, NPL, and ROA as capital, liquidity, and profitability measures during both crises don’t differ significantly. Keywords: Banking, pandemic, economic crisis.
Pijat Perineum Efektif Mencegah Robekan Perineum pada Ibu Hamil Trimester III Sampai Inpartu Kala I: Literature Review
Authors: Lumy Freike Sofie Nonce , Solang Sesca Diana , Mongkau Elvie 
Published: January 2023

World Health Organization (WHO) memperkirakan 15.000 dari sekitar 4,5 juta wanita melahirkan di Indonesia mengalami komplikasi dan menyebabkan kematian yang terjadi pada 24 jam pertama setelah melahirkan. Salah satu penyebab yaitu robekan jalan lahir yang dapat memicu perdarahan. Prevalensi ibu bersalin yang mengalami rupture perineum pada golongan umur 25-30 tahun sebesar 24% dan 32-39 tahun sebesar 62%. Tujuan penelitian adalah mengetahui efektivitas pijat perineum terhadap pencegahan robekan perineum pada ibu. Jenis penelitian ini adalah kualitatif dengan pendekatan literature review yang berkaitan dengan pijat perineum terhadap pencegahan robekan perineum pada ibu. Sumber yang digunakan dalam penelitian merupakan publikasi empat database yaitu google scholar, research gate, springers dan pubmed. Jurnal yang digunakan dalam rentang waktu antara 2016-2021 ditemukan 10 jurnal yang sesuai dengan kriteria inklusi. Hasil analisa literature dari sepuluh jurnal diperoleh bahwa secara keseluruhan menyatakan bahwa pijat perineum efektif dalam mencegah robekan perineum dengan durasi pijat 10 menit dilakukan 1 kali sehari secara rutin sejak kehamilan 36 minggu hingga inpartu kala I. Pijat perineum juga lebih efektif jika dibandingkan dengan senam kegel, teknik supercrowning. Kesimpulan yaitu Pijat perineum efektif mencegah robekan perineum. Diharapkan pijat perineum dapat menjadi salah satu perawatan untuk ibu hamil trimester III hingga inpartu kala I. dalam upaya pencegahan robekan perineum saat persalinan.
Cáncer de Cérvix, una mirada práctica
Authors: Acevedo-Jiménez Katherine , Medina Gil Manuelita , Betancur-Pulgarín Carmen Luisa 
Published: January 2023

Introducción: El cáncer de cérvix (CC) es un problema de salud pública en países desarrollados y no desarrollados; esta patología tiene repercusiones socioeconómicas en mujeres en edad reproductiva. Objetivo: Describir las características sobre métodos de prevención, tamizaje, diagnóstico y tratamiento del cáncer de cérvix. Método: Se realizó una búsqueda bibliográfica exhaustiva con un lapso de 6 años (2016-2021) en la base de datos de la Fundación Universitaria del Área Andina utilizando motores de búsqueda como Dialnet, Science Direct, Medline, LIlacs, Scopus para revisar los conceptos generales sobre cáncer de cérvix. Resultados: Es el segundo cáncer más frecuente en Colombia, la principal etiología del cáncer de cérvix es el virus del papiloma humano (VPH), el cual es un virus prevenible mediante la adecuada educación e información y seguimiento a sus lesiones precancerosas Conclusión: El CC es una patología con altas tasas de mortalidad especialmente en países en vía de desarrollo y en las infecciones asociadas a VPH de alto riesgo, afectando principalmente a mujeres en edad reproductiva y estratos socioeconómicos bajos. Los principales pilares para el manejo de esta patología siguen siendo las estrategias de salud pública, como la vacunación y realización de las pruebas de tamizaje.