bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flexible Organic Electronic Ion Pump for Flow‐Free Phytohormone Delivery into Vasculature of Intact Plants
Authors: Bernacka‐Wojcik Iwona , Talide Loïc , Abdel Aziz Ilaria , Simura Jan , Oikonomou Vasileios K. , Rossi Stefano , Mohammadi Mohsen , Dar Abdul Manan , Seitanidou Maria , Berggren Magnus , Simon Daniel T. , Tybrandt Klas , Jonsson Magnus P. , Ljung Karin , Niittylä Totte , Stavrinidou Eleni 
Published: March 2023

AbstractPlant vasculature transports molecules that play a crucial role in plant signaling including systemic responses and acclimation to diverse environmental conditions. Targeted controlled delivery of molecules to the vascular tissue can be a biomimetic way to induce long distance responses, providing a new tool for the fundamental studies and engineering of stress‐tolerant plants. Here, a flexible organic electronic ion pump, an electrophoretic delivery device, for controlled delivery of phytohormones directly in plant vascular tissue is developed. The c‐OEIP is based on polyimide‐coated glass capillaries that significantly enhance the mechanical robustness of these microscale devices while being minimally disruptive for the plant. The polyelectrolyte channel is based on low‐cost and commercially available precursors that can be photocured with blue light, establishing much cheaper and safer system than the state‐of‐the‐art. To trigger OEIP‐induced plant response, the phytohormone abscisic acid (ABA) in the petiole of intact Arabidopsis plants is delivered. ABA is one of the main phytohormones involved in plant stress responses and induces stomata closure under drought conditions to reduce water loss and prevent wilting. The OEIP‐mediated ABA delivery triggered fast and long‐lasting stomata closure far away from the delivery point demonstrating systemic vascular transport of the delivered ABA, verified delivering deuterium‐labeled ABA.
Catalyst‐ and Light‐free S−H Insertion between Phosphorodithioic Acids and Diazo Compounds: Rapid Access to Dialkylphosphorodithioates
Authors: Huang Meiling , Ye Zi , Xu Weici , Xu Ming‐Hua 
Published: March 2023

AbstractA catalyst‐ and light‐free S−H insertion of phosphorodithioic acids with diazo compounds has been developed, in which phosphorodithioic acid acts not only as an acid promoter but also as a nucleophile. This protocol features fast reaction rate, broad substrate scope, mild conditions, and simple operation, providing a cost‐effective and general approach to diverse phosphorodithioates.
Comparison of the telephone‐Montreal Cognitive Assessment (T‐MoCA) and Telephone Interview for Cognitive Status (TICS) as screening tests for early Alzheimer's disease
Authors: Chappelle Sheridan D. , Gigliotti Christina , Léger Gabriel C. , Peavy Guerry M. , Jacobs Diane M. , Banks Sarah J. , Little Emily A. , Galasko Douglas , Salmon David P. 
Published: March 2023

AbstractIntroductionRemote screening for cognitive impairment associated with Alzheimer's disease (AD) has grown in importance with the expected rise in prevalence of AD in an aging population and with new potential treatment options.MethodsThe Telephone Interview for Cognitive Status (TICS) and new telephone adaptation of the Montreal Cognitive Assessment (T‐MoCA) were administered to participants independently classified through in‐person clinical evaluation as cognitively normal (CN; n = 167), mild cognitive impairment (MCI; n = 25), or dementia (n = 23). Cerebrospinal fluid AD biomarkers were measured (n = 79).ResultsTICS and T‐MoCA were highly correlated (r = 0.787; P < 0.001): groups differed on both (CN<MCI<dementia; TICS: F [2212] = 156.66; P < 0.001; T‐MoCA: F [2210] = 143.72; P < 0.001), both effectively detected cognitive impairment (receiver operating characteristic area under the curve: TICS = 0.889; T‐MoCA = 0.902), and both negatively correlated with a composite AD biomarker (tau/amyloid beta 1‐42; TICS: r = −0.372; P = 0.001; T‐MoCA: r = −0.480; P < 0.001).DiscussionTICS and T‐MoCA are effective for remotely detecting cognitive impairment associated with AD in older adults. Strong correlation between tests provides construct validity for the newer T‐MoCA.Highlights
Construct validity for the telephone adaptation of the Montreal Cognitive Assessment (T‐MoCA) was newly established against the Telephone Interview for Cognitive Status (TICS).
TICS and T‐MoCA effectively detected cognitive impairment with remote administration.
Both tests negatively correlated with a composite cerebrospinal fluid Alzheimer's disease (AD) biomarker (tau/amyloid beta 1‐42).
Cobalt‐Catalyzed Asymmetric Deuteration of α‐Amidoacrylates for Stereoselective Synthesis of α,β‐Dideuterated α‐Amino Acids
Authors: Li Aibo , Song Xinjian , Ren Qiao , Bao Peiwang , Long Xinyu , Huang Fuli , Yuan Lvjiang , Zhou Jianrong Steve , Qin Xurong 
Published: March 2023

AbstractA cobalt‐catalyzed deuteration of amidoacrylates using deuterated methanol afforded α,β‐dideuterio‐α‐amino esters in excellent enantiomeric ratios (mostly >95 : 5) and almost complete deuteration (99 %). The new protocol was used to prepare dideuterio‐α‐amino acid fragments in some drugs. Furthermore, the stereoselective deuteration was applied in a concise synthesis of dideuterio l‐DOPA.
Selective Synthesis and Structural Transformation of a 4‐Ravel Containing Four Crossings and Featuring Cp*Rh/Ir Fragments
Authors: Dang Li‐Long , Zhang Ting‐Ting , Chen Tian , Zhao Ying , Gao Xiang , Aznarez Francisco , Ma Lu‐Fang , Jin Guo‐Xin 
Published: March 2023

AbstractIntricately interwoven topologies are continually being synthesized and are ultimately equally versatile and significant at the nanoscale level; however, reports concerning ravel structures, which are highly entwined new topological species, are extremely rare and fraught with tremendous synthesis challenges. To solve the synthesis problem, a tetrapodontic pyridine ligand L1 with two types of olefinic bond units and two Cp*M‐based building blocks (E1, M=Rh; E2, M=Ir) featuring large conjugated planes was prepared to perform the self‐assembly. Two unprecedented [5+10] icosanuclear molecular 4‐ravels containing four crossings were obtained by parallel‐displaced π⋅⋅⋅π interactions in a single‐step strategy. Remarkably, reversible structural transformations between the 4‐ravel and the corresponding metallocage could be realized by concentration changes and solvent‐ and guest‐induced effects. X‐ray crystallographic data and NMR spectroscopy provide full confirmation of these phenomena.
Synchronously Manipulating Absorption and Extinction Coefficient of Semiconducting Polymers via Precise Dual‐Acceptor Engineering for NIR‐II Excited Photothermal Theranostics
Authors: Li Jiangao , Kang Miaomiao , Zhang Zhijun , Li Xue , Xu Weilin , Wang Dong , Gao Xike , Tang Ben Zhong 
Published: March 2023

AbstractIntegrating the ultralong excitation wavelength, high extinction coefficient, and prominent photothermal conversion ability into a single photothermal agent is an appealing yet significantly challenging task. Herein, a precise dual‐acceptor engineering strategy is exploited for this attempt based on donor‐acceptor (D‐A) type semiconductor polymers by subtly regulating the molar proportions of the two employed electron acceptor moieties featuring different electronic affinity and π‐conjugation degrees, and making full use of the active intramolecular motion‐induced photothermal effect. The optimal polymer SP4 synchronously shows desirable second near‐infrared (NIR‐II) absorption, an extremely high extinction coefficient, and satisfactory photothermal conversion behavior. Consequently, the unprecedented performance of SP4 NPs on 1064 nm laser‐excited photoacoustic imaging (PAI)‐guided photothermal therapy (PTT) is demonstrated by the precise tumor diagnosis and complete tumor elimination.
Synthesis of Cationic Biphen[4, 5]arenes as Biofilm Disruptors
Authors: Du Xinbei , Ma Mengke , Zhang Yahan , Yu Xiang , Chen Longming , Zhang Han , Meng Zhao , Jia Xueshun , Chen Junyi , Meng Qingbin , Li Chunju 
Published: March 2023

AbstractSince bacteria in biofilms are inherently resistant to antibiotics and biofilm‐associated infections pose a serious threat to global public health, new therapeutic agents and schemes are urgently needed to meet clinical requirements. Here two quaternary ammonium‐functionalized biphen[n]arenes (WBPn, n=4, 5) were designed and synthesized with excellent anti‐biofilm potency. Not only could they inhibit the assembly of biofilms, but also eradicate intractable mature biofilms formed by Gram‐positive S. aureus and Gram‐negative E. coli bacterial strains. Moreover, they could strongly complex a conventional antibiotic, cefazolin sodium (CFZ) with complex stability constants of (7.41±0.29)×104 M−1 for CFZ/WBP4 and (4.98±0.49)×103 M−1 for CFZ/WBP5. Combination of CFZ by WBP4 and WBP5 synergistically enhanced biofilm eradication performance in vitro and statistically improved healing efficacy on E. coli‐infected mice models, providing a novel supramolecular strategy for combating biofilm‐associated infections.
Site‐Specific Introduction of Bioorthogonal Handles to Nanopores by Genetic Code Expansion
Authors: Yang Jing , Wang Kefan , Zhang Shanyu , Zheng Xiaocui , Cui Tongxiao , Yang Xian , Liu Yao , Lu Di , Wang Yuqin , Tian Xiao , Zhang Panke , Huang Shuo , Xie Ran 
Published: March 2023

AbstractSite‐specific functionalization of natural amino acid‐containing biological nanopores is pivotal in single molecule sensing. However, pore engineering methodologies are restricted to a limited choice and introduction of unnatural chemical components is extremely difficult. Herein we report the genetic code expansion (GCE) strategy to introduce unnatural amino acid (UAA) to an octameric Mycobacterium smegmatis porin A (MspA) nanopore. GCE allows for rapid and efficient introduction of bioorthogonal reactive site (i.e., azide) to the pore rim, and conjugation of single stranded DNA or lysozyme was demonstrated. The lysozyme‐conjugated pore was further used for the discrimination of different oligosaccharides, demonstrating a sensing capacity that a bare MspA nanopore does not possess. GCE with bioorthogonal handles, which has never been previously applied in the preparation of nanopores, is a versatile strategy for pore engineering and may further expand the application scenarios of nanopores.
Armor‐like Inorganic‐rich Cathode Electrolyte Interphase Enabled by the Pentafluorophenylboronic Acid Additive for High‐voltage Li||NCM622 Batteries
Authors: Yang Yulu , Wang Huaping , Zhu Chunlei , Ma Jianmin 
Published: March 2023

AbstractLithium metal batteries (LMBs) comprising Li metal anode and high‐voltage nickel‐rich cathode could potentially realize high capacity and power density. However, suitable electrolytes to tolerate the oxidation on the cathode at high cut‐off voltage are urgently needed. Herein, we present an armor‐like inorganic‐rich cathode electrolyte interphase (CEI) strategy for exploring oxidation‐resistant electrolytes for sustaining 4.8 V Li||LiNi0.6Co0.2Mn0.2O2 (NCM622) batteries with pentafluorophenylboronic acid (PFPBA) as the additive. In such CEI, the armored lithium borate surrounded by CEI up‐layer represses the dissolution of inner CEI moieties and also improves the Li+ conductivity of CEI while abundant LiF is distributed over whole CEI to enhance the mechanical stability and Li+ conductivity compared with polymer moieties. With such robust Li+ conductive CEI, the Li||NCM622 battery delivered excellent stability at 4.6 V cut‐off voltage with 91.2 % capacity retention after 400 cycles. The excellent cycling performance was also obtained even at 4.8 V cut‐off voltage.
Cobalt(II)‐Catalyzed C(sp3)−C(sp3) Coupling for the Direct Stereoselective Synthesis of 2‐Deoxy‐C‐Glycosides from Glycals
Authors: Zeng Mingjie , Yu Changyue , Wang Yibing , Wang Jingjing , Wang Jiang , Liu Hong 
Published: March 2023

AbstractWe report a ligand‐controlled CoII‐catalyzed C(sp3)−C(sp3) coupling hydroalkylation for direct and β‐selective synthesis of 2‐deoxy‐C‐glycosides from glycals. This reaction proceeds by a radical pathway for alkyl halide activation and is β‐selective through ligand control. This approach may inspire the development of further stereoselective coupling reactions with potential application in the field of carbohydrates.
Measurement of Nanometer Distances in Solution via 13C NMR Spectroscopy—Shrinking of Macrocycles with Increasing Temperature
Authors: Siera Hannah , Mehrparvar Saber , Fax Jonas , Kreuzahler Mathis , Haberhauer Gebhard 
Published: March 2023

AbstractFor a molecular system, size and shape are of elementary importance for its function and properties. Therefore, the determination of distances within a molecule is essential. However, the commonly used methods are only suitable for distances smaller than 4 Å or larger than 15 Å. Here, we show that by incorporating a molecular spring, we can measure distances in macrocycles in the range of 10 Å using 13C NMR spectroscopy. The accuracy of the method also allows to determine the temperature dependence of the distances. In one case, we find a contraction of the length by almost 10 % upon heating. This shrinking due to heating can be considered as inverse thermoelasticity at the molecular level and is a previously completely overlooked phenomenon that can be used in the future as a tool to change the length and, thus, the function of a system.
Highly Strong and Tough Supramolecular Polymer Networks Enabled by Cryptand‐Based Host‐Guest Recognition
Authors: Liu Yuhang , Wan Junjun , Zhao Xinyang , Zhao Jun , Guo Yuchen , Bai Ruixue , Zhang Zhaoming , Yu Wei , Gibson Harry W. , Yan Xuzhou 
Published: March 2023

AbstractSupramolecular polymer networks (SPNs) demonstrate great potential in the development of smart materials owing to their attractive dynamic properties. However, as they suffer from the inherent weak bonding of most noncovalent cross‐links, it remains a significant challenge to construct SPNs with outstanding mechanical performance. Herein, we exploit the cryptand/paraquat host‐guest recognition motifs as cross‐links to prepare a class of highly strong and tough SPNs. Unlike those supramolecular cross‐links with relatively weak binding abilities, the cryptand‐based host‐guest interactions have a high association constant and steady complexing structure, which effectively stabilizes the network and resists mechanical deformation under external force. Such favorable structural stability endows our SPNs with greatly enhanced mechanical performance, compared with the control‐1 cross‐linked by the weakly complexed crown ether/secondary ammonium salt motif (tensile strength: 21.1±0.5 vs 2.8±0.1 MPa; Young's modulus: 102.6±4.8 vs 2.1±0.3 MPa; toughness: 90.4±2.0 vs 10.8±0.6 MJ m−3). Moreover, our SPNs also retain abundant dynamic properties including good abilities in energy dissipation, reprocessability, and stimuli‐responsiveness. These findings provide novel insights into the preparation of SPNs with enhanced mechanical properties, and promote the development of high‐performance intelligent supramolecular materials.
Hybrid Aqueous/Non‐aqueous Electrolytes for Lithium‐Ion and Zinc‐Ion Batteries: A Mini‐Review
Authors: Zhang Canfu , Cai Ziyang , Huang Renzhi , Pan Huilin 
Published: March 2023

AbstractIn recent years, the development of aqueous lithium‐ion batteries and aqueous zinc‐ion batteries has received extensive attention thanks to the advantages of high safety, environmental friendliness, and easy assembly conditions. However, aqueous batteries are always restricted in terms of limited cycling stability and low energy density due to their intrinsically narrow electrochemical window, hydrogen evolution, and side reactions. These problems can be remarkably alleviated by hybridizing aqueous/non‐aqueous electrolytes; however, few detailed discussions on relevant strategies have been reported. In this mini‐review, we summarize the latest progress and contributions of various hybrid aqueous/non‐aqueous electrolytes for rechargeable aqueous lithium‐ion batteries and aqueous zinc‐ion batteries. The current challenges and development directions are also discussed for hybrid electrolytes.
Exploring thematic influences on theme park visitors' satisfaction: An empirical study on Disneyland China
Authors: Bai Shizhen , He Hao , Han Chunjia , Yang Mu , Yu Dingyao , Bi Xinrui , Gupta Brij B. , Fan Weijia , Panigrahi Prabin Kumar 
Published: March 2023

AbstractThis study aims to explore thematic influences on theme park visitors' satisfaction through user‐generated data. To this end, we first used an unsupervised machine learning method, structural topic modeling, and analyzed 112,000 reviews post by visitors to Shanghai Disney Resort from June 16, 2016 to March 4, 2022. Our findings are of great significance for reflecting consumer behavior through user‐generated data. Specifically, we find that visitors' satisfaction is highly related to service in the theme park and their playing feeling, and early tourists pay more attention to the experience of specific playing items while later tourists focus on the overall playing experience. In addition, an empirical study is conducted by treating the ratings associated with each review as dependent variable and each topic represented by comments as independent variables, which shows that the relationship between the customer reviews and ratings by tourists becomes less pronounced over time. In other words, as time goes, customers review can reflect their subjective feelings or experience, but the rating is not. We discover the “dynamics” of user‐generated data over time and gain a better understanding of the aspects and concerns of visitors' satisfaction over time. The findings of the study contribute to the literature on tourism, service, and consumer behavior while also providing valuable practical implications.
Scientific Fluency as the Greatest Strength of Chemical Biologists
Authors: Prescott Nicholas A. , Huang Hsin‐Che 
Published: March 2023

AbstractChemical biology has developed into an influential discipline in biological research, largely thanks to synergistic relationships that have arisen from the inclusion of students from diverse scientific backgrounds. We believe the greatest strengths of our field rely on active communication between fields and the fluency of chemical biologists in traversing them. In this special issue, besides cutting‐edge chemical biology research articles, we will also highlight nonscientific topics about scientific training and mentorship to foster the training of next‐generation chemical biologists.
Splenic infarcts in a lady with systemic lupus erythematosus and negative antiphospholipid antibodies—A rare case report
Authors: Ashour Amr , Faisal Mohanad , Ibrahim Elmunzer , Al‐Madani Mohammed 
Published: March 2023

AbstractSystemic lupus erythematosus is a multisystem autoimmune disease associated with a variety of arterial and venous thrombotic manifestations when combined with antiphospholipid syndrome. We present a case report of a 23‐year‐old female patient with a recent diagnosis of systemic lupus erythematosus who was admitted for abdominal pain and later diagnosed with splenic infarction via abdominal computed tomography. This was the only hematologic manifestation, with no prior history of thrombotic events or antiphospholipid antibodies.
Kounis syndrome in a patient with multivessel coronary artery disease and DRESS
Authors: La Cognata Olga , Trimarchi Giancarlo , Lo Savio Armando , Virga Vittorio , Andò Giuseppe , de Gregorio Cesare 
Published: March 2023

AbstractA 68‐year‐old man was admitted with ST‐elevation myocardial infarction and intense rash. He was diagnosed with type 2 Kounis syndrome elicited by drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome and received complete revascularization with percutaneous coronary intervention. This case highlights the complex pathophysiology of acute coronary syndrome, and the elusive link between coronary occlusion and ST‐segment deviations at ECG.
Catalytic Hydrotreatment of Algal HTL Bio‐Oil over Phosphide, Nitride, and Sulfide Catalysts
Authors: Magalhães Bruno C. , Checa Ruben , Lorentz Chantal , Prévot Mathieu , Afanasiev Pavel , Laurenti Dorothée , Geantet Christophe 
Published: March 2023

AbstractGlobal energy demand and environmental concerns about limiting CO2 emissions have been growing recently. This is why fuel production from renewable resources has become a priority. In this context, microalgae represent an attractive alternative carbon source. In this work, different supported catalysts, including metal phosphide, nitride, and sulfide, were tested for the hydroconversion of bio‐oil issued from the hydrothermal liquefaction of microalgae. Supported Ni phosphide catalysts promoted the decarboxylation and decarbonylation route, while NiMo nitride promoted the hydrodeoxygenation pathway. NiW sulfide catalysts were the most performant, producing a hydrotreated oil with the best higher heating value (HHV), lower aromaticity degree, and lower average molar mass. Among sulfide catalysts, NiWS/SiO2−Al2O3 was the least active, probably due to the inhibition of acid sites by the nitrogen compounds. However, NiWS/Al2O3 performed better, showing high hydrogenation performances, which contributed to the conversion of refractory compounds.
Coexistence of Three Different Spin States in a Cyanido‐Bridged Trinuclear Iron(III) Complex with an Unusual FeIII to Ligand Charge Transfer
Authors: He Yong , Huang Ying‐Ying , Zhu Xiao‐Quan , Fu Jin‐Hui , Wu Xin‐Tao , Sheng Tian‐Lu 
Published: March 2023

AbstractWe report a trinuclear iron(III) cyanido‐bridged complex trans‐[CpMe3FeIII(dppe)(CN)]2[FeIII(LN4)][PF6]4 (2[PF6]4) as the oxidation product of binuclear complex [CpMe3(dppe)FeIICN‐FeIII(LN4)][PF6] (1[PF6]) (CpMe3=1, 2, 4‐trimethyl‐1,3‐cyclo‐pentadienyl, dppe=1,2‐bis(diphenylphosphino)ethane, LN4=pentane‐2,4‐dione‐bis(S‐methylisothiosemicarbazonato). Complex 1[PF6] possesses an intermediate‐spin five‐coordinated FeIII (S=3/2) which couples antiferromagnetically to the π‐radical ligand (L⋅N4)2− and shows a LMCT (ligand to metal charge transfer) transition from (L⋅N4)2− to FeIII and the FeII→FeIII MMCT transition. Upon oxidation of 1[PF6], (L⋅N4)2− loses one electron to be the strong electron‐attracting ligand (LOxN4)− and the intermediate‐spin five‐coordinated FeIII (S=3/2) becomes a low‐spin six‐coordinated FeIII (S=1/2) in 2[PF6]4. Also interestingly, 2[PF6]4 presents the coexistence of three different spin states (one S=3/2 and two S=1/2) and an uncommon FeIII→(LOxN4)− MLCT transition, confirmed by the experimental results and supported by the TDDFT calculations.
Unveiling Photodegradation and Photosensitization Mechanisms of Unconjugated Pterins
Authors: Arpa Enrique M. , Corral Inés 
Published: March 2023

AbstractUnconjugated pterins are ubiquitous molecules that participate in countless enzymatic processes and are potentially involved in the photosensitization of singlet oxygen, amino acids, and nucleotides. Following electronic excitation with UV‐A light, some of these pterins degrade, producing hydrogen peroxide as the main side product. This process, which is known to take place in vivo, contributes to oxidative stress and melanocyte destruction in vitiligo. In this work, we present for the first time mechanistic insight into the formation of transient triplet species that simultaneously trigger Type I and Type II photosensitizing processes and the initiation of degradation processes. Our calculations reveal that photodegradation of 6‐biopterin, which accumulates in the skin of vitiligo patients, leads to 6‐formylpterin through a retro‐aldol reaction, and subsequently to 6‐carboxypterin through a water‐mediated aldehyde oxidation. Additionally, we show that the changes in the photosensitizing potential of these systems with pH come from the modulation of their excited‐state redox potentials.