bluuebunny/crossref_metadata_2025_split huggingface dataset:
­Ultrasonic implant site preparation vs conventional drilling: in vitro evaluation of implant site diameter.
Authors: Lahoud Pierre , Nasr Joseph Abi , Menhall Abdallah , Makary Christian 
Published: September 2023

Abstract
Objective
The aim of this study is to evaluate implant site diameter after bony preparation using either conventional drilling (CD) or ultrasonic implant site preparation (UISP).
Materials and Methods
On bovine ribs, 3mm x 10mm implant sites were prepared using two different ultrasonic protocols, UISP1 (n = 16) and UISP2 (n = 16) and a conventional drilling protocol CD (n = 16). Implant sites were then filled with resin and both cortical and cancellous horizontal sections were made in order to measure the bucco-lingual (D1) and the mesio-distal (D2) diameters of each site. Also, implant sites were prepared on bovine ribs following UISP1 (n = 12), UISP2 (n = 12) and CD (n = 12) protocols and final insertion torque (IT) was measured for each preparation. The results were statistically analyzed using the Kruskal Wallis test.
Results
Statistically significant differences were found between UISP1 (mean diameter = 3.161) and CD (mean diameter = 3.012) for D1 (P = 0.041), between UISP1 (mean diameter = 3.328) and CD (mean diameter = 3.039) for D2 (P = 0.001), between UISP1 (mean diameter = 3.328) and UISP2 (mean diameter = 3.005) for D2 (P < 0.001). No statistically significant differences were noted between UISP1 (mean diameter = 3.161) and UISP2 (mean diameter = 2.995) for D1 (p-value = 0.08), between CD (mean diameter = 3.012) and UISP2 (mean diameter = 2.995) for D1 (p-value = 0.290), and between CD (mean diameter = 3.039) and UISP 2 (mean diameter = 3.005) for D2 (p-value = 0.650). A significant difference was noted between UISP1-IT values (mean torque = 17.96 N/cm) and both UISP2-IT values (mean torque = 37.48 N/cm) (P < 0.001) and CD-IT values (mean torque = 40.99 N/cm) (P < 0.001). No statistically significant difference was noted between CD-IT (mean torque = 40.99 Ncm) and UISP2-IT (mean torque = 37.48 Ncm) (p-value = 0.488).
Conclusion
By following proper protocol UISP can be used as precisely as CD to prepare implant bed.
WITHDRAWN: PDCD6 modulates LC3-associated phagocytosis-mediated antimicrobial defense by regulating lactate metabolism
Authors: Li Tianliang , Sun Lulu , Wu Si , Wang Hui , Zhang Tianyu , Zhang Mengyu , Bai Xuepeng , Zhang Xiumei , Li Bingqing , Zhang Cai , Li Yan , Zhou Jun 
Published: September 2023

Abstract
LC3-associated phagocytosis (LAP) is critical in host defense against invading pathogens. Understanding the molecular mechanism in LAP activation could help find better treatments for infectious diseases. This study identified programmed cell death 6 (PDCD6) as a negative regulator of LAP. Lacking PDCD6, both mice and macrophages show enhanced bactericidal activity and LAP formation. Macrophages challenged with bacteria, Zymosan or Pam3CSK4 exhibit increased lactate dehydrogenase A (LDHA) activity and lactate production. Genetic ablation or pharmacological inhibition of LDHA reduced lactate levels and impaired bactericidal activity in mice and macrophages. Mechanistically, PDCD6 interacts with LDHA to downregulate lactate metabolism, reducing RUBCN lactylation at arginine 33 (K33). Increased RUBCN lactylation in PDCD6-deficient cells promotes its interaction with VPS34, activating signaling and enhancing LAP formation. These findings could contribute to developing innovative and efficient treatments for infectious diseases.
Hyperbolic exciton polaritons in a van der Waals magnet
Authors: Ruta Francesco , Zhang Shuai , Shao Yinming , Moore Samuel , Acharya Swagata , Sun Zhiyuan , Qiu Siyuan , Geurs Johannes , Kim Brian , Fu Matthew , Chica Daniel , Pashov Dimitar , Xu Xiaodong , Xiao Di , Delor Milan , Zhu X-Y. , Millis Andrew , Roy Xavier , Hone James , Dean Cory , Katsnelson Mikhail , Schilfgaarde Mark van , Basov Dmitri 
Published: September 2023

Abstract
Exciton polaritons are quasiparticles of photons coupled strongly to bound electron-hole pairs, manifesting as an anti-crossing light dispersion near an exciton resonance. Highly-anisotropic semiconductors with opposite-signed permittivities along different crystal axes are predicted to host exotic modes called hyperbolic exciton polaritons (HEPs), which permit spatial confinement beyond the material light cone and enhanced density of states. Here, we show the first observational evidence of steady-state HEPs using a cryogenic near-field microscope in the van der Waals magnet chromium sulfide bromide. At low temperature, in the magnetically-ordered state, anisotropic exciton resonances sharpen, driving the permittivity negative along one crystal axis and enabling HEP propagation. Further, we demonstrate coupling of HEPs to excitonic sidebands and increasing exciton spectral weight near the magnetic transitions corresponding to exciton wavefunction delocalization. Our findings open new pathways to nanoscale manipulation of excitons and light, including routes to magnetic, nonlocal, and quantum polaritonics in a light-emitting material.
A Sub-Parsec Supermassive Black Hole Binary Powers Precessing Outflows in NGC 4388
Authors: Muller-Sanchez Francisco , Ruby Mason , Reich Logan , Shaver Skylar , Brown Christian , Hicks Erin , Malkan Matthew 
Published: September 2023

Abstract
Models of hierarchical galaxy formation predict the existence of supermassive black hole binaries (SMBHBs). As two galaxies merge, their respective supermassive black holes (SMBHs) migrate to the center of the merger remnant driven by dynamical friction. Subsequently, they form a gravitationally-bound binary. The binary separations are very small and difficult to image. To date, only one SMBHB has been imaged with a separation of 7.3 pc. Here we report the detection of a possible SMBHB with a separation of 0.02 pc in the galaxy NGC 4388. Using high-resolution observations from the Keck OSIRIS Nearby AGN survey (KONA), we have analyzed the two-dimensional (2D) spatial distribution and kinematics of the stars and the molecular and ionized gas in the central region of NGC 4388. We find that the nearly edge-on galaxy exhibits a nuclear disk of molecular gas which is misaligned by ~15° from the large-scale disk and approaches the orientation of the maser disk at scales <30 pc. To the southwest, an extraplanar outflow of highly-ionized gas is extended along a position angle of 205°. We observe pronounced velocity reversals along the outflow axis, involving shifts in line-of-sight velocities from -180 to +180 km/s, which indicate precession of the kinematic major axis of the outflow. A simple model of a helical outflow precessing around an axis close to the plane of the sky can reproduce the observations. The outflow precesses with an angle of 40° and a precession period of ~1.6 Myr. The launch region lies inside a radius r<0.3 pc, as indicated by the size of an apparently warped maser disk. These results suggest that the precession is caused by the tidal interaction between a SMBHB and a circumbinary disk.
In-plane Hall effect in rutile oxide films induced by the Lorentz force
Authors: Wu Yizheng , Cui Yongwei , Li Zhaoqing , Chen Haoran , Chen Yue , Wu Yunzhuo , Pei Ke , Wu Tong , Xie Nian , Che Renchao , Qiu Xuepeng , Liu Yi , Yuan Zhe 
Published: September 2023

Abstract
The conventional Hall effect is linearly proportional to the field component or magnetization component perpendicular to a film1. Despite the increasing theoretical proposals on the Hall effect to the in-plane field or magnetization in various special systems induced by the Berry curvature2-8, such an unconventional Hall effect has only been experimentally reported in Weyl semimetals and in a heterodimensional superlattice9-12. Here, we report an unambiguous experimental observation of the in-plane Hall effect (IPHE) in centrosymmetric rutile RuO2 and IrO2 single-crystal films under an in-plane magnetic field. The measured Hall resistivity is found to be proportional to the component of the applied in-plane magnetic field along a particular crystal axis and to be independent of the current direction or temperature. Both the experimental observations and theoretical calculations confirm that the IPHE in rutile oxide films is induced by the Lorentz force. Our findings can be generalized to ferromagnetic materials for the discovery of in-plane anomalous Hall effects and quantum anomalous Hall effects. In addition to significantly expanding knowledge of the Hall effect, this work opens the door to explore new members in the Hall effect family.
Conditional Survival with Time of Overall Survival and Disease-free Survival for Mid or Low Locally Advanced Rectal Cancer
Authors: Wang Guancong , Li Jiasen , Zeng Qunzhang , Huang Ying , Guo Yincong 
Published: September 2023

Abstract

Aim To evaluate the changes of conditional survival (CS) for mid or low locally advanced rectal cancer (LARC) and to determine how the prognostic factors affecting CS evolve over time.
Methods We analyzed data of 1833 patients from two centers. Kaplan-Meier and multivariate Cox regression were used to calculate conditional disease-free survival (cDFS) and conditional overall survival (cOS). Multivariable Cox regression models were used to calculate proportional hazard ratios (HR) for the prediction of cDFS and cOS.
Funding The 5-year OS and DFS estimates were 83.3% and 78.3%, respectively. Given a 1-, 2-, 3-, 4- and 5-year survivorship, the 5-year cOS rates increased to 83.7%, 85.0%, 85.8%, 89.1%, and 92.6%, respectively. Similarly, given a 1-, 2-, 3-, 4- and 5-year disease-free survivorship, the 5-year cDFS rates increased to 81.8%, 86.0%, 88.3%, 92.3%, and 94.6%, respectively. The impact of well-known prognostic factors on CS estimates relevance changed or even disappeared over time. Whereas distance to the anal verge (DTAV) and neoadjuvant rectal (NAR) score was the most stable and reliable prognostic factors for CS. Independent effects of NAR score (HRs 1.68, 1.85, 2.10, 1.99, 3.38, respectively) and DTAV (HRs 0.48, 0.52, 0.52, 0.47, 0.34, respectively) factors on cOS can be found, at all-time points including baseline, 1, 2, 3, and 4 years. Interestingly, a consistent independent effect of NAR (HRs 1.71, 1.89, 1.83, 1.84, 2.78, respectively) score on cDFS at baseline, 1, 2, 3, and 4 years survived, and DTAV (HRs 0.51, 0.61, 0.62, 0.45, respectively) on cDFS at survived for within 3 years. The stratified analysis revealed that the lower the DTAV or higher the NAR score, the lower the 5-year CS probability over the entire time after surgery, which supports the results of multifactorial Cox regression.
Conclusions CS rates increase over time in LARC patients, especially in patients with long-term survival. Factors of influence may change with prolonged survival, DTAV and NAR score were persistent predictors of long-term prognosis.
Evaluation of a School-based Health Education Program on Hepatitis B prevention practice in Rural South-Western, Nigeria
Authors: Olaoye Titilayo , Osie-Efietie Blessing , Ogunsanmi Ololade O. , Mustapha Adebayo M. , Asekun-Olarinmoye Ifeoluwapo , Atulomah Nnodimele Onuigbo 
Published: September 2023

Abstract
This study employed a quasi-experimental design to assess the effect of a school-based health education program on Hepatitis B prevention practice of 256 selected secondary school students from four schools in Ogun state and randomized into three intervention schools teacher-instructed (E1), peer-directed (E2) and a combination of these two (E3) respectively with a control group (C). The theory-based educational intervention was implemented for six weeks and data analyzed considered baseline and follow-up mean and standard deviation scores of outcome variables of Hepatitis B prevention practice of participants. Statistical analysis of ANOVA and Cohen’s D Effect Size (ES) was used to quantify the effectiveness of the intervention on outcome variables at 5% level of significance.
At baseline, there was no significant difference (p > 0.05) in the mean Hepatitis B prevention practice scores between the four groups E1 (17.21±3.03), E2 (15.57±1.90), E3 (17.90±3.10), and C (15.20±2.44). The means scores of participants in the experimental groups increased significantly between baseline and follow-up among E1 (from 17.2 to 23.2; p < 0.05), E2 (from13.5 to 23.5; p <0.05), E3 (from 17.9 to 25.2; p < 0.05) and control (from 15.2 to 15.3; p > 0.05). The effectiveness of the intervention was evaluated at follow-up by comparing ES of each experimental group thus, 2.17, 95%CI: (1.70-2.64; p <0.02), 2.46, 95%CI: 1.97-2.96; p <0.05), 2.16, 95%CI: (1.69-2.64; p < 0.05) and 0.021, 95%CI: (-0.40-0.44; p >0.05) respectively.
Largely, the participants from E2 showed more improvement in prevention practices than their counters from E1, E3, and control. A combination of teachers and students should be engaged as change agents in schools for Hepatitis B virus infection control.
Cyclical Vomiting Syndrome Complicated with Superior Mesenteric Artery Syndrome: a case report
Authors: Liu Bo , Liu Yang , Yuan Minlan , Zhang Wei 
Published: September 2023

Abstract
Background
Cyclic vomiting syndrome (CVS) is a chronic functional gastrointestinal disorder involving the gut-brain axis that is characterized by recurring episodes of nausea, vomiting, abdominal pain, and interspersed complete normal periods. Superior mesenteric artery syndrome (SMAS) results from a decreased angle between the aorta and the superior mesenteric artery, presenting with duodenal obstruction symptoms such as early satiety, nausea, vomiting, and postprandial epigastric pain. Instances of coexisting entities are rarely documented in the available literature.
Case presentation
A 20-year-old female patient diagnosed with CVS displays an ongoing fear of vomiting and adopts conscious dietary restrictions, leading to severe malnutrition. Consequently, she developed the comorbidity of SMAS. In addition to enteral and parenteral nutritional support, she was administered antiemetic and antianxiety medications and engaged in mindfulness-based cognitive behavioral therapy.
Conclusions
To our knowledge, this is the first reported case of SMAS developing due to CVS. Medical practitioners should be aware of this potential cooccurrence, particularly when a patient with a history of cyclic vomiting syndrome demonstrates significant and swift weight loss. Effectively preventing or managing complications associated with CVS is of paramount importance.
Enhancing COVID-19 Diagnosis Accuracy and Transparency with eXplainable Artificial Intelligence (XAI) Techniques
Authors: Malik Sonika , Aggarwal Tanay 
Published: September 2023

Abstract
The COVID-19 pandemic has strained global healthcare systems, necessitating efficient screening tools for the timely identification and management of SARS-CoV-2 infections. This research proposes a novel approach that utilizes machine learning and XAI techniques to create an effective screening tool for COVID-19 [1]. By training a prediction model on a dataset of over 50,000 tested individuals, incorporating features like age, sex, contact history, and clinical symptoms, accurate estimation of SARS-CoV-2 infection risk is achieved. Integration of XAI techniques, such as feature importance analysis and decision boundary visualization, enhances transparency, improves accuracy, and fosters confidence among healthcare professionals [2-5]. The objective is to address comprehension challenges and effectively leverage diverse knowledge for diagnosis, empowering global medical staff with a valuable tool for triaging patients and optimizing resource allocation. This research significantly contributes to combating the COVID-19 pandemic and enhancing healthcare systems' resilience against similar challenges.
Big data-based artificial intelligence for efficient digital screen usage management among Chinese children and adolescents during the COVID-19 pandemic
Authors: Wang Jifang , Shen Yang , Zhao Jing , Wang Xiaoying , Chen Zhi , Han Tian , Huang Yangyi , Wang Yuliang , Zhao Wuxiao , Wu Yuchen , Wen Bo , Hong Yongting , Zhou Xingtao , Xu Ye 
Published: September 2023

Abstract
This study investigated screen-time behaviors of Chinese children and adolescents and the efficacy of artificial intelligence (AI)-based alerts in screen-time behavior correction. Data from 6,716 children and adolescents with AI-enhanced tablets that recorded behavioral and light environment data during use were analyzed. The mean daily screen time was 67.10 ± 48.26 min. The screen time of junior-high-school students exceeded 1.5 h (92.50 ± 75.06 min) and that of school-aged participants exceeded 4 h per week. Children younger than two years used tablets for more than 45 min per day. Learning accounted for more than 50% of participants’ screen time. The distance alarm was triggered 807,355 times. Some participants (31.03%, 2061/6643) used tablets for 1 h at an average distance < 50 cm. Over 70% of the participants used the tablet under an illuminance < 300 lx during the day and more than 60% under an illuminance < 100 lx at night. More than 85% of the participants’ ambient light exceeded 4,000 K color temperature at night. The screen time of school-aged participants was longer than that of preschool-aged children. The recorded illumination was insufficient and was paired with a high color temperature at night. AI can effectively remind children and adolescents to correct unhealthy behaviors during screen time.
The level of IL-8 in TMERA cells as a biomarker for hormonotherapy in thymoma
Authors: Yu xintao , Yu Lei , Cui Jian , Du Xin , Gao Xiang , Yang Xingguo 
Published: September 2023

Abstract
Thymoma is the most common type of neoplasm in the anterior mediastinum. However, it can be challenging to differentiate thymoma from other anterior mediastinum tumors in this region through imaging examinations. Therefore, the identification of a reliable, unique characteristic for the further study of thymoma is crucial. Our study confirms an increase in TEMRA cells in type B thymoma and suggests that the level of IL-8 in TEMRA cells may be a biomarker indicating hormonotherapy can be an effective treatment for patients with type B1 and B2 thymoma patients.
Impact of Motor Task Conditions on End-point Kinematics and Trunk Movements during Goal-directed Arm Reach
Authors: Kim Bokkyu , Girnis Jaimie , Sweet Vanessa , Nobiling Tobias , Agag Tarek , Neville Christopher 
Published: September 2023

Abstract
Task conditions significantly impact human motor control. We investigated how task type, difficulty, and constraints influence the kinematics of goal-directed arm reaching. Non-disabled young adults performed two distinct goal-directed arm reaching tasks: pointing and picking up an object with chopsticks. These tasks were carried out under various conditions, including constrained and unconstrained elbow extension and two different task difficulties. We collected kinematic data using a 3-D motion capture system and analyzed the effects of different task conditions on kinematic variables using linear mixed-effects regression analysis. Our findings revealed statistically significant differences in kinematics between the two tasks. Arm reaching during the picking-up task was slower and exhibited jerkier movements compared to the pointing task. Additionally, when arm reaching was performed with constrained elbow extension, it led to slower and jerkier movements, with an increased involvement of trunk movements compared to the unconstrained condition. These findings show that complex manipulative motor tasks requiring higher hand dexterity necessitate feedback-based control of arm reaching, but simple pointing tasks requiring less hand dexterity do not. In conclusion, our study sheds light on the influence of task conditions on goal-directed arm reaching kinematics and provides valuable insights into the motor control strategies involved in different tasks.
Identification of the Tagetes erecta Linn. Extract’s potentials against influenza A based on bioinformatics analysis and experimental study
Authors: Kim Minjee , Nowakowska Aleksandra , Kim Jaebum , Kim Young Bong 
Published: September 2023

Abstract
Background: Tagetes erecta Linn. (TE) is used to treat cardiovascular, renal, and gastrointestinal diseases. In this study, we aimed to investigate the active compounds and targets of the TE extract in influenza A infections.
Method: Active compounds and targets of the TE extract were identified using network pharmacology. Pathway and target studies were conducted using the Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Expression Omnibus (GEO) gene difference, and molecular docking analyses. In vitro validation of the TE extract was performed using antiviral and plaque reduction assays.
Results: From 6 compounds, 95 active targets, 887 influenza-associated target genes, and 14 intersecting core targets were identified. A compound–target network was constructed and two compounds (lutein and beta-carotene) were identified. Protein–protein interaction and GEO analysis revealed interleukin (IL)-6 as a hub gene. In vitro experimental results revealed that the TE extract exerted therapeutic rather than protective effects.
Conclusions: Overall, we identified the two main active compounds in the TE extract, lutein and beta-carotene, and IL-6 as an important target associated with influenza. Moreover, our findings confirmed the activity of the TE extract against the influenza A virus.
Mechanical loading-induced change of bone homeostasis is mediated by PGE2-driven hypothalamic interoception
Authors: Cao Xu , Gao Feng , HU QIMIAO , Qi Cheng , Wan Mei , Ficke James , Zheng Junying 
Published: September 2023

Abstract
Bone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the mechanical loading environment. However, it is unclear whether the signals of bone cells in response to mechanical stress are processed and interpreted in the brain. In this study, we found that the hypothalamus of the brain regulates bone remodeling and structure by perceiving bone PGE2 concentration in response to mechanical loading. Bone PGE2 levels are in proportion to their weight bearing. When weight bearing changes in the tail-suspension mice, the PGE2 concentrations in bones change in line with their weight bearing changes. Deletion of Cox2 or Pge2 in the osteoblast lineage cells or knockout Ep4 in sensory nerve blunts bone formation in response to mechanical loading. And sensory denervation also significantly reduces mechanical load-induced bone formation. Moreover, mechanical loading induces CREB phosphorylation in the hypothalamic ARC region to inhibit sympathetic TH expression in the PVN for osteogenesis. Finally, we show that elevated PGE2 is associated with ankle osteoarthritis (AOA) and pain. Together, our data demonstrate that in response to mechanical loading, skeletal interoception occurs in the form of hypothalamic processing of PGE2-driven peripheral signaling to maintain physiologic bone homeostasis, while chronically elevated PGE2 can be sensed as pain during AOA and implication of potential treatment.