bluuebunny/crossref_metadata_2025_split huggingface dataset:
PS-C03-13: THE POTENTIAL AND EXPECTATIONS OF CONSUMER-DRIVEN MARKETING FOR TELEMEDICINE IN HYPERTENSION FINDINGS FROM A CONCEPT SURVEY AND DEPTH INTERVIEWS
Authors: Shioya Saori , Yatabe Junichi , Ishida Kazuya , Yatabe Midori , Terai Taro 
Published: January 2023

We provide telemedicine services to manage hypertension, utilizing our consumer-driven marketing knowledge. We have established a system jointly with TelemedEASE, a general incorporated association, and launched the service “Hypertension e-medical” in 2021.
We performed quantitative and qualitative surveys to analyze consumer psychology and examined the essence of the value provided by telemedicine services for hypertension.

Survey Methods:
Findings
(1) Depth interviews
The primary intention of new users of telemedicine was “convenience,” such as no need for visiting hospital and reduced waiting time, while the next largest potential value was “a sense of reassurance”. Many patients have concerns that they are unable to discuss with their doctors regarding hospital visits and medication. In some cases, patients felt that they didn’t receive sufficient explanations from their doctors after only a short consultation, and in other cases, even if they did receive explanations, their concerns were not fully resolved. The ability to monitor one's own symptoms by measuring one's blood pressure at home and the “a sense of reassurance” provided by medical staff watching over the smartphone Apps can be of great value to patients.
(2) Concept survey
Of all subjects including treated and untreated patients, 76.1% had blood pressure of 130/85 mmHg or higher, and 62.5% was on regular blood pressure medication. Majority (56.4%) regularly measured their home blood pressure. At the time of the survey, 56.4% knew about online visits but only 2.4% had used it. Currently, only 13.2% of the respondents were willing to use telemedicine.
Patients in their 30 s and 40 s seemed to value “peace of mind”, as the intention to use the service was about 1.7 times higher when the focus concept was “peace of mind” compared to when it was “convenience” in this age group.

Conclusion:
In Japan, telemedicine from the first visit recently became permanently available. The number of users is expected to increase.
Providing value based on an accurate understanding of such consumer insights is important. The findings may help lead to designing services to encourage the initiation and continuation of treatment in patients with hypertension.
PS-C04-1: COMPARISON OF THE CARDIO-ANKLE VASCULAR INDEX AND AUGMENTATION INDEX AS AN INDEX OF ARTERIOSCLEROSIS IN PATIENTS WITH ESSENTIAL HYPERTENSION
Authors: Morimoto Satoshi , Horiuchi Sayuri , Kimura Miwa , Kimura Shihori , Yamashita Kaoru , Takano Noriyoshi , Seki Yasufumi , Bokuda Kanako , Watanabe Daisuke , Ichihara Atsuhiro 
Published: January 2023

Objective:
Arteriosclerosis leads to various serious diseases that substantially reduce quality of life. When treating hypertension, it is important to evaluate the degree of arteriosclerosis. In recent years, the cardio-ankle vascular index and augmentation index have been frequently used as indicators of arterial wall sclerosis. However, the superiority of either the cardio-ankle vascular index or the augmentation index as an index of arteriosclerosis remains unclear. Therefore, the present study compared the usefulness of these two indices as an index of arteriosclerosis.

Design and method:
Associations between the cardio-ankle vascular index or augmentation index and risk factors for arteriosclerosis and other indices of arteriosclerosis in 535 consecutive patients with essential hypertension were evaluated.

Results:
The cardio-ankle vascular index was significantly correlated with age, hemoglobin A1c, brain natriuretic peptide, and estimated glomerular filtration rate. In contrast, the augmentation index showed significant correlations only with age, brain natriuretic peptide, and estimated glomerular filtration rate. In addition, these correlations with the augmentation index were generally weaker than those with the cardio-ankle vascular index. The cardio-ankle vascular index, but not the augmentation index, was significantly correlated with flow-mediated dilation, an index of vascular endothelial function, and carotid intima-media thickness, an index of carotid atherosclerosis. Similar results were observed in subgroups stratified by sex and age.

Conclusions:
These data indicate that the cardio-ankle vascular index is more closely associated with risk factors for arteriosclerosis and other indices of arteriosclerosis than the augmentation index, suggesting that the cardio-ankle vascular index may be superior to the augmentation index as an index of arteriosclerosis.
PS-C05-2: COMPARISON OF NON-INVASIVE VASCULAR LOAD ESTIMATION OF THE SYSTEMIC AND PULMONARY ARTERIAL CIRCULATION IN PATIENTS UNDERGOING INVESTIGATION FOR PULMONARY HYPERTENSION
Authors: Adji Audrey , Kearney Katherine , Hungerford Sara , Song Ning , Kotlyar Eugene , Lau Edmund , Jabbour Andrew , Haywrd Christopher 
Published: January 2023

Objective:
Quantification of characteristic impedance (Zc) as an estimate of pulsatile load is now feasible using a hybrid non-invasive and invasive technique in any specific vascular bed. Vascular resistance (mean pressure ÷ mean flow) in a system may ignore the pulsatile component of ventricular hydraulic work incorporating the dynamic interaction between vascular resistance, compliance and wave reflection. This interaction is represented by vascular impedance which offers a comprehensive assessment of hydraulic load. This study aims to compare systemic (Ao-Zc) and pulmonary (PA-Zc) Zc in a cohort of patients with suspected pulmonary hypertension (PH) referred for routine right heart catheterisation (RHC) followed by cardiac magnetic resonance (CMR).

Design and Methods:
Thirty participants (77% females, mean 56 ± 18 years) were recruited, and had routine right heart catheterisation (RHC) to measure systolic (sPAP), diastolic (dPAP), mean (mPAP), and PA wedge pressures (PAWP), cardiac output (CO) and PVR. The remaining patients were assigned to the control group. Ao pressures were calibrated to brachial cuff pressures and derived from radial tonometric pressure acquisition (systolic, AoSP; diastolic, AoDP; mean, MP) before/ after CMR. Ao and PA volumetric flows were recorded using 3T cardiac magnetic resonance (CMR) using phase-contrast velocity quantification. Zc was expressed as the relationship of PA pulsatile pressure to PA pulsatile flow in the frequency domain.

Results:
80% of patients had evidence of PH on RHC and classified as pre-capillary PH (n = 11, PrecPH), isolated post-capillary PH (n = 8, IpcPH) and combined PH (n = 5, CpcPH). In patients without PH, Ao-Zc was 83.0 ± 38.4 dynes.s.cm-5 and PA-Zc was 48.8 ± 13.7 dynes.s.cm-5, with PA-Zc being 33% lower than those with PH (72.9 ± 28.0 dynes.s.cm-5, p = 0.005) and Ao-Zc non-significantly lower (77.3 ± 29.6 dynes.s.cm-5, p = 0.575). In patients with PH, different hemodynamic relationships were observed. In those with PrecPH, PA-Zc was 9% higher than Ao-Zc (p = 0.74).
An inverse relationship between PA-Zc and Ao-Zc was found in those with IpcPH (p = 0.11). This relationship approached 1:1 (p = 0.27) in patients with CpcPH. PA-Zc spectra in CpcPH subjects were qualitatively similar to Ao-Zc spectra, although the ratio of PVR to Zc was smaller.

Conclusion:
We describe a straightforward method to measure and compare pulsatile vascular load of the systemic and pulmonary circulations simultaneously, allowing further quantification of systemic/pulmonary vascular interactions. Further research is required to evaluate small-vessel contributions to the arterial circulation, especially in the pulmonary system.
PS-C05-4: EFFECT OF EVOLOCUMAB ON CAROTID MAXIMUM INTIMA-MEDIA THICKNESS IN PATIENTS UNDERGOING STATIN THERAPY
Authors: Hirai Keiji , Hirai Aizan , Morishita Yoshiyuki 
Published: January 2023

Background:
This study investigated the effect of evolocumab, a fully human monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9, on carotid maximum intima media thickness (IMT), an established surrogate marker of atherosclerosis, in patients taking statins with and without renal impairment (estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2).

Methods:
The annual change in carotid maximum IMT before and after administration of evolocumab was retrospectively analyzed in 229 statin treated patients (148 men and 81 women; mean age: 72.6 ± 8.6 years). The annual change in carotid maximum IMT was compared between patients with and without renal impairment (n = 73; mean eGFR 48.8 ± 8.3 ml/min/1.73 m2 vs. n = 156; mean eGFR 77.1 ± 11.9 ml/min/1.73 m2). The changes in lipid parameters were also evaluated.

Results:
Evolocumab significantly reduced the progression rate of carotid maximum IMT in whole patients (0.17 ± 0.38 mm/year to 0.08 ± 0.47 mm/year, p < 0.005). Evolocumab significantly reduced the progression rate of carotid maximum IMT in patients without renal impairment (0.18 ± 0.39 mm/year to 0.08 ± 0.46 mm/year, p < 0.05) but did not in patients with renal impairment (0.15 ± 0.36 mm/year to 0.06 ± 0.50 mm/year, p = 0.12). However, it significantly reduced total cholesterol, low density lipoprotein cholesterol, triglyceride, and lipoprotein (a), and increased high density lipoprotein cholesterol in both patients with and without renal impairment.

Conclusion:
Evolocumab attenuated the progression of carotid maximum IMT in patients undergoing statin therapy without renal impairment but not in patients with renal impairment. However, it improved lipid parameters in both patients with and without renal impairment. These results suggest that evolocumab protects against carotid atherosclerosis in only patients undergoing statin therapy without renal impairment.
PS-C05-6: EFFECT OF CORONARY RISK FACTORS AND PRESENCE OF CORONARY ARTERY DISEASE ON DIURNAL VARIATION IN VASCULAR ENDOTHELIAL FUNCTION
Authors: Yamashita Sumiyo , Tamai Nozomu , Sugiura Tomonori , Takase Hiroyuki , Murai Shunsuke , Saeki Tomoaki , Murakami Yoshimasa , Ohte Nobuyuki , Dohi Yasuaki , Seo Yoshihiro 
Published: January 2023

Purpose:
Vascular endothelial dysfunction, an early change in atherosclerosis, is an independent risk factor for cardiovascular disease and is known to be reversible; RH-PAT (Reactive Hyperemia Peripheral Arterial Tonometry) can noninvasively measure vascular endothelial function. However, it is difficult to interpret the pathological significance of a single measurement because of many modifying factors such as diet, temperature, and medications. In this study, we aimed to investigate the effects of coronary risk factors and the presence of coronary artery disease on the diurnal variation of vascular endothelial function.

Methods:
Between May 2013 and May 2015, 498 patients (31% female, 19–94 years old, mean 66.7 ± 12.5 years) who were admitted to our hospital for cardiac catheterization, percutaneous coronary angioplasty, catheter ablation, or lower extremity peripheral angioplasty underwent RH-PAT examination (The Endo PAT 2000 system, Itamar Medical Ltd, Caesarea, Israel). The correlation between coronary risk factors and RH-PAT results was investigated. Correlations between coronary risk factors and RH-PAT results were also examined in patients who underwent coronary angiography.

Results:
The Reactive Hyperemia Index (RHI) was significantly lower in the group with smoking habit than in the nonsmoking group. Neither the number of coronary artery branches involved, the presence or absence of atrial fibrillation, nor the responsiveness to coronary spasm induction tests correlated significantly with the RHI. On the other hand, there was a significant difference between the morning and afternoon measurements in the group without coronary artery lesions, but no significant difference between the morning and afternoon measurements in the group with coronary artery lesions, regardless of the number of lesioned branches.

Conclusions:
Patients with a history of smoking, coronary artery lesions, and coronary spasms may have impaired diurnal variation in vascular endothelial function, suggesting that RH-PAT may be useful as an early indicator of coronary artery disease when measured at different time points.
PS-C06-4: RELATIONSHIP BETWEEN URINARY MICROALBUMIN AND LIPID ACCUMULATION PRODUCT AND VISCERAL ADIPOSITY INDEX IN PATIENTS WITH ESSENTIAL HYPERTENSION
Authors: Shu Meiqi , Hu Guangmei , Paermanjiang Naderemu , Xu Xinjuan 
Published: January 2023

Objective:
To explore the relationship between urinary microalbumin and lipid accumulation product and visceral adiposity index in patients with essential hypertension.

Design and method:
A total of 463 essential hypertension patients admitted to the Department of Hypertension of the First Affiliated Hospital of Xinjiang Medical University from April 2020 to October 2021 were selected. Patients were grouped according to 24-hours urinary microalbumin and divided into normal 24-hours urinary microalbumin group and elevated 24-hours urinary microalbumin group to compare the clinical data of the two groups and analyze the risk factors of elevated urinary microalbumin.

Results:
The 24-hours urinary microalbumin was positively associated with lipid accumulation product and visceral adiposity index in patients with essential hypertension(all P < 0.01). The risk of elevated 24-hours urinary microalbumin may increase with increasing lipid accumulation product,visceral adiposity index. After adjusting for age,sex,admission systolic blood pressure,admission diastolic blood pressure,body mass index,triglycerides,high density lipoprotein cholesterol,serum creatinine,the OR (95%CI) of lipid accumulation product in the fourth quantile group was 4.770 (1.680∼13.545) compared with the first quantile of lipid accumulation product. The OR (95%CI) values of visceral adiposity index in the second,third and fourth quartile groups were 3.364 (1.330∼8.512),3.440 (1.249∼9.472),and 5.213 (1.556∼17.461),compared with the first quartile group of visceral adiposity index. Analysis of the receiver operating characteristic curve suggested that the risk of elevated urinary microalbumin increases when the lipid accumulation product is greater than 32.236 and the visceral adiposity index is greater than 2.031.

Conclusion:
When the lipid accumulation product and visceral adiposity index increase in patients with essential hypertension, they may lead to an increased risk of increased urinary microalbumin.
PS-C06-6: LONG-CHAIN FATTY ACIDS IN SARCOPENIA PATIENTS WITH CARDIOVASCULAR DISEASES IMPORTANCE OF N-9 MONOUNSATURATED FATTY ACIDS
Authors: Katoh Atsushi , Morita Kohsuke , Sasaki Motoki , Okina Norihito , Niiyama Hiroshi , Kai Hisashi 
Published: January 2023

Background:
Long chain fatty acids are essential components of energy supply, cellular membranes and autacoid synthesis. It was suggested that long chain fatty acids might be involved in pathophysiology underlying sarcopenia. Therefore, we investigated the association between sarcopenia and serum long chain fatty acid profile in patients with cardiovascular diseases.

Methods:
We retrospectively investigated 308 cardiovascular patients (age: 72 ± 12, 174 males) admitted in our hospital. All patients were examined sarcopenia diagnostic tests and serum free fatty acids analysis.

Results:
Seventy-seven patients (25%) were diagnosed as sarcopenia. Serum fatty acid weight percentages of nervonic acid and erucic acid (n-9 long chain monounsaturated fatty acids) increased in sarcopenia patients than non-sarcopenia patients, while most of other long chain fatty acids weight percentages decreased in sarcopenia patients. Nervonic acid, which was an independent factor for sarcopenia on binary logistics regression analysis (B = 2.559, p < 0.001), correlated negatively with skeletal muscle index (r = -0.331, p < 0.001), gait speed (r = -0.387, p < 0.001), and handgrip strength (r = -0.372, p < 0.001). These significant relationships were certified in the groups of men, women, younger (≦ 73 years old), and elder (≧ 74 years old). On ROC curve analysis, the cut-off of nervonic acid weight percentage for diagnosis of sarcopenia was 1.37% with a sensitivity and specificity of 76.6% and 65.1%, respectively.

Conclusions:
Nervonic acid, a n-9 monounsaturated fatty acid, could be a new marker for sarcopenia in patients with cardiovascular diseases. Further study with large patient number is necessary to determine the roles of long chain fatty acids in sarcopenia.
PS-C06-7: NT- PRO BNP IN ARTERIAL HYPERTENSION
Authors: Unurjargal Tsolmon , Sodovsuren Naranchimeg , Khorloo Chingerel 
Published: January 2023

Objectives of the present study were to evaluate the association of N-terminal pro-B-type natriuretic peptide to hypertension and to compare NT-pro BNP levels in groups with and without arterial hypertension.

Design and method:
The study included 253 participants with cardiovasular risk aged 35–64 years and who had no clinical symptoms of heart failure. All participants were divided into to two groups: hypertensive and normotensive. High risks for heart failure included arterial hypertension, diabetes, obesity, excessive drinking of alcohol, smoking and family history of cardiovascular disease were detected by clinical examinations. Hypertension was defined as systolic BP ≧ 140 mm Hg, diastolic BP ≧ 90 mm Hg, and/or receiving treatment with anti-hypertensive agents. The NT-pro BNP determination was performed using immunoassay analyzer which utilizes reagent strip to obtain quantitative NT- pro BNP results in plasma. The cut-off point for NT-pro BNP was 125 pg/ml. All statistical analyses were made with the SPSS version 25.0. Differences between the study groups were analyzed with the chi-square test for categorical variables. P value less than 0.05 is considered as statistically significant.

Results:
The study sample consisted of 100 men and 153 women. The mean age of participants was 51.1 ± 8.2 years. In all, 49% of participants were hypertensive.
The mean age, body mass index and abdominal circumference in hypertensive group were significantly higher than in normotensive group. Elevated NT-pro BNP levels ≧ 125 pg/ml were detected in 12.6% of participants. Increased NT- pro BNP values were detected in 21.0% subjects with hypertension and in 4.6% subjects without hypertension. The mean N-terminal pro-B-type natriuretic peptide value among patients with and without hypertension were 145.0 ± 98.0 pg/ml and 112.6 ± 59.6 pg/ml. Multivariate linear regression analysis showed that age β; = 0.240, P = 0.021 and systolic blood pressure β; = 0.256, P = 0.008 were positively correlated with NT-pro BNP levels in hypertensive group.

Conclusions:
NT-pro BNP levels were significantly increased in participants with hypertension.
The present study showed that age and systolic blood pressure were significantly positively associated with NT- pro BNP levels. In case of elevated NT- pro BNP we recommend using echocardiography
PS-C07-1: CENTRAL AND BRACHIAL PULSE PRESSURE PREDICTS CARDIOVASCULAR AND RENAL EVENTS IN TREATED HYPERTENSIVE PATIENTS
Authors: Takenaka Tsuneo , Ohno Yoichi , Eguchi Kazuo , Miyashita Hiroshi , Suzuki Hiromichi , Shimada Kazuyuki 
Published: January 2023

Purposes:
Central blood pressure is a stronger predictor of cardiovascular prognosis rather than brachial blood pressure. Reflection wave reaches abdominal aorta sooner than ascending aorta. Thus, the contribution of central pulse pressure (cPP) to renal events may differ from that to cardiovascular events.

Methods:
The sub-analysis of ABC-J II study was performed. Subjects were 3434 treated hypertensive patients with mean follow-up of 4.7 years. Left ventricular hypertrophy, an index of cardiovascular risk, correlated with cPP better than central systolic blood pressure in this cohort. The contribution of brachial pulse pressure (bPP) and cPP to cardiovascular and renal events were analyzed. Multivariate Cox regressions were performed by restricting independent variables according to the number of events. The independent variables, which were either significant in univariate Cox regression or of clinical interest, were applied.

Results:
Total of 63 cardiovascular and 34 renal events were occurred. Multivariate Cox proportional-hazard analysis revealed that sex (p < 0.001), height (p < 0.05), history of cardiovascular diseases (p < 0.001), numbers of antihypertensive drugs (p < 0.05) and cPP (p < 0.05) contributed to cardiovascular events (Table 1). However, multivariate Cox proportional-hazard analysis disclosed that baseline serum creatinine (p < 0.001) and bPP (p < 0.05) predicted renal events (Table 2).

Conclusions:
The present findings suggest that cPP and bPP contribute to cardiovascular and renal events in treated hypertensive patients.
PS-C07-4: COST EFFECTIVE SCREENING FOR BLOOD PRESSURE IN A LMIC: COMPARISON OF STANDARD AND RANDOM METHODS FOR HOME BLOOD PRESSURE MONITORING
Authors: Khan Aamir Hameed , Baqar Jaffer Bin , Jaffari Anzal Abbas , Javed Wajiha 
Published: January 2023

Background:
Hypertension is a leading risk factor for worldwide mortality and has become an important public health concern. Globally one billion people are suffering from hypertension and this rate may reach up to 1.56 billion by 2025. The prevalence of hypertension in Pakistani adults is upto 50%. The National Institute for Clinical Excellence and Pakistan Hypertension League guidelines recommend home blood pressure monitoring (HBPM) for screening and diagnosis of hypertension in Pakistan; whereas, the current gold standard of hypertension diagnosis is still ABPM. However, the utility of HBPM is restricted due to the cumbersome standard method for HBPM, which requires timed blood pressure measurements pre-breakfast & pre dinner.. We need pragmatic ways of measuring home blood pressure which will lead to higher patient compliance.

Objective:
To compare the limits of agreement between standard and random methods for HBPM in patients with or without hypertension.

Design & Method:
A cross sectional study with n = 345 participants will be conducted in The Aga Khan University Hospital. After receiving due ethical approvals, participants 18 80 years of age will be recruited with or without hypertension. A HBPM device (OMRON M7 Intelli) will be provided to each participant for 14 days. In first week, BP readings will be taken as per standard method (2 readings pre breakfast & 2 pre-dinner) and random method (6 readings anytime during a day) will be followed in subsequent week. Besides demographics, history of comorbid, medications status and BP charting, international physical activity questionnaire short form will be filled. SPSS software will be used for data management and analyses. Pearson correlation coefficients, Bland Altman plots and ROC curve will be used to determine the correlation limits of agreement and level of accuracy in predicting hypertension for both methods.