bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Evolution of Classic Hodgkin Lymphoma Revealed Through Whole-Genome Sequencing of Hodgkin and Reed Sternberg Cells
Authors: Maura Francesco , Ziccheddu Bachisio , Xiang Jenny Z. , Bhinder Bhavneet , Rosiene Joel , Abascal Federico , Maclachlan Kylee H. , Eng Kenneth Wha , Uppal Manik , He Feng , Zhang Wei , Gao Qi , Yellapantula Venkata D. , Trujillo-Alonso Vicenta , Park Sunita I. , Oberley Matthew J. , Ruckdeschel Elizabeth , Lim Megan S. , Wertheim Gerald B. , Barth Matthew J. , Horton Terzah M. , Derkach Andriy , Kovach Alexandra E. , Forlenza Christopher J. , Zhang Yanming , Landgren Ola , Moskowitz Craig H. , Cesarman Ethel , Imielinski Marcin , Elemento Olivier , Roshal Mikhail , Giulino-Roth Lisa 
Published: February 2023

Abstract

The rarity of malignant Hodgkin and Reed Sternberg (HRS) cells in classic Hodgkin lymphoma (cHL) limits the ability to study the genomics of cHL. To circumvent this, our group has previously optimized fluorescence-activated cell sorting to purify HRS cells. Using this approach, we now report the whole-genome sequencing landscape of HRS cells and reconstruct the chronology and likely etiology of pathogenic events leading to cHL. We identified alterations in driver genes not previously described in cHL, APOBEC mutational activity, and the presence of complex structural variants including chromothripsis. We found that high ploidy in cHL is often acquired through multiple, independent chromosomal gains events including whole-genome duplication. Evolutionary timing analyses revealed that structural variants enriched for RAG motifs, driver mutations in B2M, BCL7A, GNA13, and PTPN1, and the onset of AID-driven mutagenesis usually preceded large chromosomal gains. This study provides a temporal reconstruction of cHL pathogenesis.

Significance:
Previous studies in cHL were limited to coding sequences and therefore not able to comprehensively decipher the tumor complexity. Here, leveraging cHL whole-genome characterization, we identify driver events and reconstruct the tumor evolution, finding that structural variants, driver mutations, and AID mutagenesis precede chromosomal gains.
This article is highlighted in the In This Issue feature, p. 171
APRRX1Signature Identifies TIM-3 and VISTA as Potential Immune Checkpoint Targets in a Subgroup of Microsatellite Stable Colorectal Cancer Liver Metastases
Authors: Nygaard Vigdis , Ree Anne Hansen , Dagenborg Vegar Johansen , Børresen-Dale Anne-Lise , Edwin Bjørn , Fretland Åsmund Avdem , Grzyb Krzysztof , Haugen Mads H. , Mælandsmo Gunhild M. , Flatmark Kjersti 
Published: February 2023

Disease recurrence and drug resistance are major challenges in the clinical management of patients with colorectal cancer liver metastases (CLM), and because tumors are generally microsatellite stable (MSS), responses to immune therapies are poor. The mesenchymal phenotype is overrepresented in treatment-resistant cancers and is associated with an immunosuppressed microenvironment. The aim of this work was to molecularly identify and characterize a mesenchymal subgroup of MSS CLM to identify novel therapeutic approaches. We here generated a mesenchymal gene expression signature by analysis of resection specimens from 38 patients with CLM using ranked expression level of the epithelial-to-mesenchymal transition–related transcription factor PRRX1. Downstream pathway analysis based on the resulting gene signature was performed and independent, publicly available datasets were used to validate the findings. A subgroup comprising 16% of the analyzed CLM samples were classified as mesenchymal, or belonging to the PRRX1high group. Analysis of the PRRX1 signature genes revealed a distinct immunosuppressive phenotype with high expression of immune checkpoints HAVCR2/TIM-3 and VISTA, in addition to the M2 macrophage marker CD163. The findings were convincingly validated in datasets from three external CLM cohorts. Upregulation of immune checkpoints HAVCR2/TIM-3 and VISTA in the PRRX1high subgroup is a novel finding, and suggests immune evasion beyond the PD-1/PD-L1 axis, which may contribute to poor response to PD-1/PD-L1–directed immune therapy in MSS colorectal cancer. Importantly, these checkpoints represent potential novel opportunities for immune-based therapy approaches in a subset of MSS CLM.Significance:CLM is an important cause of colorectal cancer mortality where the majority of patients have yet to benefit from immunotherapies. In this study of gene expression profiling analyses, we uncovered novel immune checkpoint targets in a subgroup of patients with MSS CLMs harboring a mesenchymal phenotype.
Introduction: Art's Histories Without Art History
Authors: Cabañas Kaira Marie 
Published: February 2023

Abstract
The introductory text situates the therapeutic practices of Gina Ferreira and Lula Wanderley in relation to the work of Brazilian modernist artist Lygia Clark. Ferreira is a social psychologist who uses the arts—for instance, photography and film—for the socialization and treatment of psychiatric patients. Wanderley is an artist who brings creativity into the realm of psychiatric care. Both have significantly expanded the sites and amplified the applications of Clark's Estruturação do self (Structuration of the self) therapy sessions by working in public psychiatric hospitals and clinics in Rio de Janeiro and with marginalized populations. In “Lend Me Your Eyes,” Gina Ferreira offers a poetic account of both Lygia Clark's practice and how communication became a “‘therapeutic’ possibility” for the artist. These thoughts frame Ferreira's narration of her clinical care of a client (patient) named Pedro. In “The Silence That Words Hold,” Lula Wanderley describes his artistic engagement with psychiatry and his use of Clark's therapy with clients such as Rosa. The two articles compelling attest to how Clark's Estruturação do self resonates beyond the institutionalized spaces of the art museum and the academy.
Low Vision Impairs Implicit Sensorimotor Adaptation in Response to Small Errors, But Not Large Errors
Authors: Tsay Jonathan S. , Tan Steven , Chu Marlena A. , Ivry Richard B. , Cooper Emily A. 
Published: February 2023

AbstractSuccessful goal-directed actions require constant fine-tuning of the motor system. This fine-tuning is thought to rely on an implicit adaptation process that is driven by sensory prediction errors (e.g., where you see your hand after reaching vs. where you expected it to be). Individuals with low vision experience challenges with visuomotor control, but whether low vision disrupts motor adaptation is unknown. To explore this question, we assessed individuals with low vision and matched controls with normal vision on a visuomotor task designed to isolate implicit adaptation. We found that low vision was associated with attenuated implicit adaptation only for small visual errors, but not for large visual errors. This result highlights important constraints underlying how low-fidelity visual information is processed by the sensorimotor system to enable successful implicit adaptation.
Relative Contribution of Moisture Transport during TC-Active and TC-Inactive Periods to the Precipitation in Henan Province of North China: Mean State and an Extreme Event
Authors: Chen Yangruixue , Liu Bo , Luo Yali , Martinez-Villalobos Cristian , Ren Guoyu , Huang Yongjie , Zhang Sihan , Sun Yong , Zhang Zhongshi 
Published: February 2023

Abstract
A Lagrangian model—the Hybrid Single-Particle Lagrangian Integrated Trajectory model (HYSPLIT)—is used to quantify changes in moisture sources and paths for precipitation over North China’s Henan Province associated with tropical cyclone (TC) over the western North Pacific (WNP) during July–August of 1979–2021. During TC-active periods, an anomalous cyclone over the WNP enhances southeasterly and reduces southwesterly moisture transport to Henan. Accordingly, compared to TC-inactive periods, moisture contributions from the Pacific Ocean (PO), eastern China (EC), and the local area (Local) are significantly enhanced by 48.32% (16.73% versus 11.28%), 20.42% (9.44% versus 7.84%), and 2.89% (4.91% versus 4.77%), respectively, while moisture contributions from the Indian Ocean (IO), Southwestern China (SWC), Eurasia (EA), and the South China Sea (SCS) are significantly reduced by −31.90% (8.61% versus 12.64%), −16.27% (4.60% versus 5.50%), −8.81% (19.10% versus 20.95%), and −6.92% (12.18% versus 13.09%). Furthermore, the moisture transport for a catastrophic extreme rainfall event during 17–22 July (“21⋅7” event) influenced by Typhoon Infa is investigated. Compared to the mean state during TC-active periods, the moisture contribution from the PO was substantially increased by 126.32% (37.87% versus 16.73%), while that from IO significantly decreased by −98.26% (0.15% versus 8.61%) during the “21⋅7” event. Analyses with a bootstrap resampling method show that moisture contributions from the PO fall outside the +6σ range, for both the TC-active and TC-inactive probability distributions. Thus, the “21⋅7” event is rare and extreme in terms of the moisture contribution from the PO, with the occurrence probability being less than 1 in 1 million times.

Significance Statement
Henan, one of the most populated provinces in China, experienced a catastrophic extreme precipitation event in July 2021 (the “21⋅7” event), coinciding with the activity of a tropical cyclone (TC) over the western North Pacific, which helps establish the moisture channel. Using a Lagrangian model, we provide a better understanding of how moisture transport changes associated with TC for the mean state of 1979–2021, and reveal how extreme is the moisture transport for the “21⋅7” event with the bootstrap technique. It is found that during active TC periods, the moisture contribution from the Pacific Ocean (the Indian Ocean) is significantly enhanced (reduced). For every 1 000 000 six-day events, less than one instance like the “21⋅7” event should be expected.
Understanding Differences in Sea Surface Temperature Intercomparisons
Authors: Huang Boyin , Yin Xungang , Carton James A. , Chen Ligang , Graham Garrett , Liu Chunying , Smith Thomas , Zhang Huai-Min 
Published: February 2023

Abstract
Our study shows that the intercomparison among sea surface temperature (SST) products is influenced by the choice of SST reference, and the interpolation of SST products. The influence of reference SST depends on whether the reference SSTs are averaged to a grid or in pointwise in situ locations, including buoy or Argo observations, and filtered by first-guess or climatology quality control (QC) algorithms. The influence of the interpolation depends on whether SST products are in their original grids or preprocessed into common coarse grids. The impacts of these factors are demonstrated in our assessments of eight widely used SST products (DOISST, MUR25, MGDSST, GAMSSA, OSTIA, GPB, CCI, CMC) relative to buoy observations: (i) when the reference SSTs are averaged onto 0.25° × 0.25° grid boxes, the magnitude of biases is lower in DOISST and MGDSST (<0.03°C), and magnitude of root-mean-square differences (RMSDs) is lower in DOISST (0.38°C) and OSTIA (0.43°C); (ii) when the same reference SSTs are evaluated at pointwise in situ locations, the standard deviations (SDs) are smaller in DOISST (0.38°C) and OSTIA (0.39°C) on 0.25° × 0.25° grids; but the SDs become smaller in OSTIA (0.34°C) and CMC (0.37°C) on products’ original grids, showing the advantage of those high-resolution analyses for resolving finer-scale SSTs; (iii) when a loose QC algorithm is applied to the reference buoy observations, SDs increase; and vice versa; however, the relative performance of products remains the same; and (iv) when the drifting-buoy or Argo observations are used as the reference, the magnitude of RMSDs and SDs become smaller, potentially due to changes in observing intervals. These results suggest that high-resolution SST analyses may take advantage in intercomparisons.

Significance Statement
Intercomparisons of gridded SST products be affected by how the products are compared with in situ observations: whether the products are in coarse (0.25°) or original (0.05°–0.10°) grids, whether the in situ SSTs are in their reported locations or gridded and how they are quality controlled, and whether the biases of satellite SSTs are corrected by localized matchups or large-scale patterns. By taking all these factors into account, our analyses indicate that the NOAA DOISST is among the best SST products for the long period (1981–present) and relatively coarse (0.25°) resolution that it was designed for.
A Multiresolution Ensemble Hybrid 4DEnVar with Variable Ensemble Sizes to Improve Global and Tropical Cyclone Track Numerical Prediction
Authors: Jones Erin A. , Wang Xuguang 
Published: February 2023

Abstract
The current global operational four-dimensional ensemble-variational (4DEnVar) data assimilation (DA) system at NCEP adopts a background ensemble at a reduced resolution, which restricts the range of spatial scales that the ensemble background error covariance can resolve. A prior study developed a multiresolution ensemble 4DEnVar method and determined that this approach can provide a comparable forecast to an approach using solely high-resolution members, while substantially reducing the computational cost. This study further develops the multiresolution ensemble 4DEnVar approach to allow for a flexible number of low- and high-resolution ensemble members as well as varying localization length scales between the high- and low-resolution ensembles. Three 4DEnVar experiments with the same computational costs are compared. The first experiment has an 80-member high-resolution background ensemble with single-scale optimally tuned localization (SR-High). The second and third experiments utilize the multiresolution background ensembles. One has 130 low-resolution and 40 high-resolution members (MR170) while the other has 180 low-resolution members and 24 high-resolution members (MR204). Both multiresolution ensemble experiments utilize differing localization radii with ensemble resolution. Despite having the same costs, both MR170 and MR204 improves global forecasts and decreases tropical cyclone track errors for up to 5 days’ lead time compared to SR-High. Improvements are most apparent in larger-scale features, such as jet streams and the environmental steering flow of tropical cyclones. Additionally, MR170 outperforms MR204 in terms of global and tropical cyclone track forecasts, demonstrating the value of both increasing sampling at large scales and retaining substantial information at small scales.
Future Prospects of the Gravity Model of Trade: A Bibliometric Review (1993–2021)
Authors: Jadhav Suhas , Ghosh Ishita 
Published: February 2023

The gravity model of trade (GMoT) has become popular among practitioners and academics lately, essentially because of its power to provide a comprehensive explanation of real-world trade data. Complementing this are Viner’s concepts of trade creation (TC) and trade diversion (TD), which have been crucial in the development of a conceptual framework for evaluating the trade implications of a trade agreement. This article attempts to conduct a bibliometric analysis for estimating TC and TD using the GoMT. It has been observed that the TC and TD estimations following the use of the GoMT are few. Additionally, TC and TD estimations for free trade agreements (FTA) have been conducted, but not so much for regional trade agreements (RTA). As a result, a broad range of research can be conducted, especially given the recent dynamic environment for new RTAs. A bibliometric analysis was undertaken to evaluate the current level of research on GMoT. The search was conducted through Scopus where 648 documents were retrieved and examined. The article indicates key findings and discusses future research prospects. JEL: F10, F13, F14
Mindfulness-Based Attention Training in the Navy: A Feasibility Study
Authors: Roemer Anja , Sutton Anna , Grimm Carsten , Kimber Stafford , Medvedev Oleg N. 
Published: February 2023

Mind wandering is common during daily activities and is even more prevalent under stressful conditions, which could lead to lapses in attention and poor performance. Newly recruited military personnel who undergo demanding training often experience high levels of stress. It is therefore imperative to find ways to foster mental health and avoid performance deterioration related to mind wandering in times of intense military training. This feasibility study investigated the effectiveness of an established low-dose mindfulness-based intervention (MBI), called Mindfulness-based Attention Training (MBAT), on mind wandering, attentional performance, and well-being, delivered by a facilitator who was taught how to deliver MBAT. A sample of newly recruited Royal New Zealand Navy (RNZN) Junior Officers ( n = 17) undergoing demanding training participated in the 8-week long MBI with one weekly contact session. Measures of well-being and the Sustained Attention to Response Task (SART) were completed 4 weeks prior to the MBAT, at the start of the MBAT, at the end of the MBAT and 4 weeks after completion of the MBAT. Results suggest that MBAT might protect from performance decline during intense training and enhance levels of well-being at follow-up. These findings highlight the valuable role of mindfulness as a component in military training.
Aortic regurgitation progression after mitral valve replacement for rheumatic heart disease
Authors: Ho Tri Huynh Quang , Pham Thuy Thi Thanh 
Published: February 2023

Objectives Little is known about the fate of untreated moderate aortic regurgitation after mitral valve replacement for rheumatic heart disease. The aim of this study was to compare the progression to significant aortic valve disease of untreated moderate and mild aortic regurgitation after mitral valve replacement for rheumatic heart disease. Methods Among patients who underwent mitral valve replacement for rheumatic heart disease without concomitant aortic valve intervention at our institution between January 2005 and December 2017, we selected 338 patients with pure aortic regurgitation (273 patients with mild and 65 patients with moderate aortic regurgitation). Results After a median follow-up of 10.0 years, 16 patients developed significant aortic valve disease. Freedom from significant aortic valve disease at 3 years, 8 years, and 14 years was 100%, 97.8 ± 1.1%, and 93.5 ± 2.3% in patients with mild aortic regurgitation, and 98.5 ± 1.5%, 94.5 ± 3.2%, and 80.6 ± 7.5% in patients with moderate aortic regurgitation (log-rank test: p = 0.007). Seven patients with mild aortic regurgitation and two patients with moderate aortic regurgitation underwent aortic valve replacement. Conclusions After mitral valve replacement for rheumatic heart disease, untreated moderate aortic regurgitation progressed more frequently to significant aortic valve disease compared to untreated mild aortic regurgitation. A marked difference in freedom from significant aortic valve disease occurred after eight years. Aortic valve replacement was rarely needed.
Comparative Efficacy, Safety, and Acceptability of Pimavanserin and Other Atypical Antipsychotics for Parkinson’s Disease Psychosis: Systematic Review and Network Meta-Analysis
Authors: Yunusa Ismaeel , Rashid Nazia , Seyedin Roxanna , Paratane Deepika , Rajagopalan Krithika 
Published: February 2023

Background The current comparative efficacy, safety, and acceptability of atypical antipsychotics (AAPs) in treating Parkinson's Disease Psychosis (PDP) are not entirely understood. Objective To evaluate comparative efficacy, safety, and acceptability of AAPs in patients with PDP. Methods We conducted a systematic review and a network meta-analysis to compare the efficacy, safety, and acceptability of pimavanserin, quetiapine, olanzapine, clozapine, ziprasidone, and risperidone. We estimated relative standardized mean differences (SMDs) for continuous outcomes and odds ratios (OR) for binary outcomes, with their respective 95% confidence intervals (CIs). Results We included 19 unique studies evaluating AAPs in a total of 1,242 persons with PDP. Based on Clinical Global Impression Scale for Severity, pimavanserin (SMD, −4.81; 95% CI, −5.39, −4.24) and clozapine (SMD, −4.25; 95% CI, −5.24, −3.26) significantly improved symptoms compared with placebo. Also, compared to placebo, pimavanserin (OR, 1.16; 95% CI, 1.07, 1.24) significantly improved psychotic symptoms based on Scale for Assessment of Positive Symptoms for Parkinson's Disease Psychosis/Hallucinations and Delusions scores. In comparison to placebo, clozapine (SMD, −0.69; 95% CI, −1.35, −0.02), pimavanserin (SMD, −0.01; 95% CI, −0.56, 0.53), and quetiapine (SMD, 0.00; 95% CI, −0.68, 0.69) did not impair motor function per Unified Parkinson's Disease Rating scale. Based on Mini-Mental State Examination scale, quetiapine (SMD, 0.60; 95% CI, 0.07, 1.14) significantly impaired cognition compared to placebo. Conclusions In patients with PDP, pimavanserin and clozapine demonstrated significant improvement in psychosis without affecting motor function. With quetiapine being associated with a significant decline in cognition and despite not impairing motor function, our findings suggest that it should be avoided in patients with PDP and reduced cognitive abilities.
Planning an Escape: Considerations for the Development of Applied Escape Rooms
Authors: Doherty Shawn M. , Griggs Andrew C. , Lazzara Elizabeth H. , Keebler Joseph R. , Gewertz Bruce L. , Cohen Tara N. 
Published: February 2023

Background Teams are essential to a wide array of applications and organizations often utilize varying interventions to improve the effectiveness of their teams. Due to their collaborative and modifiable characteristics, escape rooms are being increasingly utilized as an avenue to both deliver team interventions and to function as testbeds in research. Escape rooms are complex, interdependent activities which warrant careful planning to be effectively implemented. Despite the growing literature base concerning escape rooms, there is still limited practical guidance to inform the development of an escape room. Aim The purpose of this article is to provide seven considerations that are relevant to the development, implementation, and effectiveness of an escape room. Specifically, guidance is provided in determining the objectives, identifying a theme, assigning the roles, establishing participant interdependence, selecting a venue, designing the puzzles, and creating the assessments. Conclusion The considerations provided in this article can advance the science underlying the use of escape rooms and preclude difficulties associated with their use.