bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluorine speciation and origin of Early-Middle Triassic bentonite deposits in Sichuan Basin, South China
Authors: Lin Yongjie , Zheng Mianping , Zhang Yongsheng , Xing Enyuan 
Published: January 2023

Fluorine (F) is one of the most important environmentally harmful elements released by volcanic activity, and the bentonite deposits that formed from volcanic ashes are potentially harmful to the environment. However, the mechanisms governing F-rich bentonite formation and its F speciation composition remain enigmatic. The F-rich bentonite deposits are widely distributed in the Early-Middle Strata of the Sichuan Basin, South China. Detailed mineralogical and geochemical studies were conducted on the bentonite deposits from five sections of the Sichuan Basin. X-ray diffraction (XRD) analyses indicate that the F-rich bentonites mainly contain quartz, carbonates (calcite and dolomite) or gypsum, and clay minerals, while the clay minerals are dominated by illite and illite/smectite (I/S). Clay mineralogical studies suggest that bentonites were transformed from volcanic ashes during diagenesis by smectite illitization. The major and trace element distribution in F-rich bentonite deposits altered from volcanic ashes is most likely derived from felsic magmas, and alteration of the parent rocks (e.g., rhyolites) to bentonite is associated with leaching and subsequent removal of F. The total fluorine content (FTOT) of the bentonite samples ranged from 1,162 mg/kg to 2,604 mg/kg (average = 1773 mg/kg), well above the average FTOT contents of soils in the world. The results of the sequential extraction experiments show that the highest content is residual-fluorine (Fres), followed by carbonate-fluorine (Fcar) with a mean value of 1,556 mg/kg and 186 mg/kg, indicating carbonate is an important F sink in bentonite deposits. The average fluorine value of organic fluorine (For), Fe/Mn oxide-fluorine (Ffm) and exchangeable fluorine (Fex) are relatively low with an average value of 17.5 mg/kg, 6.8 mg/kg and 4.1 mg/kg, respectively. However, water-soluble fluorine (Fws) has a mean value of 4.0 mg/kg, which is higher than the corresponding average value in soils in an area susceptible to endemic fluorosis in China. Based on the characteristic of fluorine speciation, the fluorine in bentonite deposits may pose a risk to the environment. This study makes an important contribution to a better understanding of the characteristic of fluorine speciation in bentonites and the formation mechanism that governs fluorine enrichment in bentonites.
Coalbed methane accumulation, in-situ stress, and permeability of coal reservoirs in a complex structural region (Fukang area) of the southern Junggar Basin, China
Authors: Li Meng , Li Mingjie , Pan Jienan , Gao Di , Cao Yunxing 
Published: January 2023

The enrichment of coalbed methane (CBM), in-situ stress field, and permeability are three key factors that are decisive to effective CBM exploration. The southern Junggar Basin is the third large CBM basin in China but is also known for the occurrence of complex geological structures. In this study, we take the Fukang area of the southern Junggar Basin as an example, coalbed methane accumulation and permeability, and their geological controls were analyzed based on the determination of geological structures, in-situ stress, gas content, permeability, hydrology and coal properties. The results indicate that gas contents of the Fukang coal reservoirs are controlled by structural framework and burial depth, and high-to-ultra-high thickness of coals has a slightly positive effect on gas contents. Perennial water flow (e.g., the Baiyanghe River) favors gas accumulation by forming a hydraulic stagnant zone in deep reservoirs, but can also draw down gas contents by persistent transportation of dissolved gases to ground surfaces. Widely developed burnt rocks and sufficient groundwater recharge make microbial gases an important gas source in addition to thermogenic gases. The in-situ stress field of the Fukang area (700–1,500 m) is dominated by a normal stress regime, characterized by vertical stress &gt; maximum horizontal stress &gt; minor horizontal stress. Stress ratios, including lateral stress coefficient, natural stress ratios, and horizontal principal stress ratio are all included in the stress envelopes of China. Permeability in the Fukang area is prominently partitioned into two distinct groups, one group of low permeability (0.001–0.350 mD) and the other group of high permeability (0.988–16.640 mD). The low group of permeability is significantly formulated by depth-dependent stress variations, and the high group of permeability is controlled by the relatively high structural curvatures in the core parts of synclines and the distance to the syncline core. Meanwhile, coal deformation and varying dip angles intensify the heterogeneity and anisotropy of permeability in the Fukang area. These findings will promote the CBM recovery process in China and improve our understanding of the interaction between geological conditions and reservoir parameters and in complex structural regions.
Late-Quaternary paleoearthquakes along the Liulengshan Fault on the northern Shanxi Rift system
Authors: Sun Wen , He Honglin , Shi Feng , Wei Zhanyu , Sun Haoyue , Su Peng 
Published: January 2023

The Liulengshan Fault (LLSF), which lies on the northeastern edge of the Ordos Plateau, is a controlling boundary fault in the northern part of the Shanxi Rift system (SRS). The displaced landforms show that the fault has undergone strong and frequent late-Quaternary seismic activities. In 1989 and 1991, two moderate–strong earthquake swarms (Ms=6.1 and Ms=5.8) successively occurred in the LLSF, and GPS velocity shows that the areas are extending at around 1–2 mm/a. However, there is no surface-rupturing earthquake reported on the LLSF in historical records. Thus, the study of paleoseismic history and rupture behavior of paleoearthquakes in late-Quaternary on the LLSF is of fundamental importance for understanding the future seismic risk of this fault. To solve these problems, we conducted paleoseismological trench excavations at two sites on the LLSF to establish its paleoearthquake history. On the basis of the field geological survey and interpretation of high-precision topographic data, we carried out large-scale fault mapping and excavated two trenches in Xujiabao and Luofengwa across the LLSF. Then, four events in the Xujiabao trench and three events in the Luofengwa trench are identified. Finally, combined with radiocarbon dating (C14), optically stimulated luminescence (OSL) and OxCal modeling, we constrained the ages of these events. Together with the previous results of paleoseismology inYin et al. (1997), we consider that different segments of the LLSF may rupture together at the same time. Therefore, a total of six paleoearthquake events since late-Quaternary have been finally confirmed at 44,151–30881a, 40,163-28045a, 28,233-19215a, 16,742-12915a, 12,788-8252a, and 8203–2300a BP. According to the empirical relationships between moment magnitude and rupture length, the best estimated magnitude is inferred to be in the range between Mw 6.9 and Mw 7.7. Considering the strong late-Quaternary activity and a long earthquake elapsed time, we propose that the LLSF might have a high seismic hazard potential in the near future.
Associations of age, BMI, and renal function to cortisol after dexamethasone suppression in patients with adrenal incidentalomas
Authors: Olsen Henrik , Olsen Martin 
Published: January 2023

IntroductionThe specificity of cortisol after 1 mg dexamethasone (cortisolDST) ≥50 nmol/L as a criterion for mild autonomous cortisol secretion (MACS) is approximately 85% in patients with adrenal incidentalomas (AI). The aim was to study the associations of cortisolDST to age, BMI, and renal function.MethodsWe studied 1,129 patients with AI examined from 2005 to 2015 at Skåne University Hospital and Helsingborg Hospital. The covariates studied were gender, age, BMI, estimated glomerular filtration rate (eGFR), treatment with inhalation steroids, size of the AI, and size of the smallest AI in patients with bilateral AI (set to 0 in unilateral AI). We used machine learning models to uncover potential nonlinear associations. They were trained to fit the data and examined using feature importance analysis and partial dependence plots. Partial dependence plots show the marginal effect on cortisolDST of a covariate averaging over other covariates.ResultsCortisolDST was strongly associated with the size of the AI and weakly associated with age, BMI, and eGFR according to the feature importance analysis. The partial dependence plots indicated relatively linear relationships for cortisolDST to age (positively) and eGFR (negatively). The association between cortisolDST and BMI was nonlinear. At BMI below 30 kg/m2, cortisolDST was negatively associated with BMI, but it was unchanged at higher BMI levels. Using linear regression, we found that cortisolDST increased by 11% (95% CI, 7%–14%) for each 10-year increase in age. In patients with a BMI below 30 kg/m2, cortisolDST increased by 23% (95% CI, 16%–31%) for each 5 kg/m2 decrease in BMI. We found no association at BMI levels above 30 kg/m2. CortisolDST increased by 9% (95% CI, 6%–11%) for each 10 ml/min/1.73m2 decrease in eGFR.ConclusionsCortisolDST is positively associated with age, negatively with BMI if below 30 kg/m2, and negatively with eGFR. These associations should be considered before diagnosing MACS.
Genome-wide characterization of mitochondrial DNA methylation in human brain
Authors: Devall Matthew , Soanes Darren M. , Smith Adam R. , Dempster Emma L. , Smith Rebecca G. , Burrage Joe , Iatrou Artemis , Hannon Eilis , Troakes Claire , Moore Karen , O’Neill Paul , Al-Sarraj Safa , Schalkwyk Leonard , Mill Jonathan , Weedon Michael , Lunnon Katie 
Published: January 2023

BackgroundThere is growing interest in the role of DNA methylation in regulating the transcription of mitochondrial genes, particularly in brain disorders characterized by mitochondrial dysfunction. Here, we present a novel approach to interrogate the mitochondrial DNA methylome at single base resolution using targeted bisulfite sequencing. We applied this method to investigate mitochondrial DNA methylation patterns in post-mortem superior temporal gyrus and cerebellum brain tissue from seven human donors.ResultsWe show that mitochondrial DNA methylation patterns are relatively low but conserved, with peaks in DNA methylation at several sites, such as within the D-LOOP and the genes MT-ND2, MT-ATP6, MT-ND4, MT-ND5 and MT-ND6, predominantly in a non-CpG context. The elevated DNA methylation we observe in the D-LOOP we validate using pyrosequencing. We identify loci that show differential DNA methylation patterns associated with age, sex and brain region. Finally, we replicate previously reported differentially methylated regions between brain regions from a methylated DNA immunoprecipitation sequencing study.ConclusionsWe have annotated patterns of DNA methylation at single base resolution across the mitochondrial genome in human brain samples. Looking to the future this approach could be utilized to investigate the role of mitochondrial epigenetic mechanisms in disorders that display mitochondrial dysfunction.
Investigate the genetic mechanisms of diabetic kidney disease complicated with inflammatory bowel disease through data mining and bioinformatic analysis
Authors: Zhang Xiaoyu , Xiao Huijie , Fu Shaojie , Yu Jinyu , Cheng Yanli , Jiang Yang 
Published: January 2023

BackgroundPatients with diabetic kidney disease (DKD) often have gastrointestinal dysfunction such as inflammatory bowel disease (IBD). This study aims to investigate the genetic mechanism leading to IBD in DKD patients through data mining and bioinformatics analysis.MethodsThe disease-related genes of DKD and IBD were searched from the five databases of OMIM, GeneCards, PharmGkb, TTD, and DrugBank, and the intersection part of the two diseases were taken to obtain the risk genes of DKD complicated with IBD. A protein–protein interaction (PPI) network analysis was performed on risk genes, and three topological parameters of degree, betweenness, and closeness of nodes in the network were used to identify key risk genes. Finally, Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed on the risk genes to explore the related mechanism of DKD merging IBD.ResultsThis study identified 495 risk genes for DKD complicated with IBD. After constructing a protein–protein interaction network and screening for three times, six key risk genes were obtained, including matrix metalloproteinase 2 (MMP2), hepatocyte growth factor (HGF), fibroblast growth factor 2 (FGF2), interleukin (IL)-18, IL-13, and C–C motif chemokine ligand 5 (CCL5). Based on GO enrichment analysis, we found that DKD genes complicated with IBD were associated with 3,646 biological processes such as inflammatory response regulation, 121 cellular components such as cytoplasmic vesicles, and 276 molecular functions such as G-protein-coupled receptor binding. Based on KEGG enrichment analysis, we found that the risk genes of DKD combined with IBD were associated with 181 pathways, such as the PI3K-Akt signaling pathway, advanced glycation end product–receptor for AGE (AGE-RAGE) signaling pathway and hypoxia-inducible factor (HIF)-1 signaling pathway.ConclusionThere is a genetic mechanism for the complication of IBD in patients with CKD. Oxidative stress, chronic inflammatory response, and immune dysfunction were possible mechanisms for DKD complicated with IBD.
Combined effect of diabetes and frailty on mortality among Chinese older adults: A follow-up study
Authors: Shi Jing , Tao Yongkang , Wang Lixiang , Chen Shuqiang , Zhou Ziyi , Meng Li , Zhou Baiyu , Duan Chunbo , Xi Huan , Yu Pulin 
Published: January 2023

BackgroundFrailty and diabetes are two important health problems associated with aging in older individuals. This paper seeks to analyze the frailty in older adults suffering from diabetes and the combined effect of diabetes and frailty on mortality risk.MethodsThe frailty index (FI) model was employed when evaluating frailty among the older adults based on the baseline data conducted in 2009; and death as outcome variables collected in 2020 were analyzed. The influence of diabetes on age-related changes in frailty in the older adults and resulting mortality rates was analyzed. Cox regression and Kaplan-Meier curves were applied to evaluate the influence on the risk of death and the 11-year survival of the older adults with varying diabetes and frailty statuses.ResultsUltimately, 1,213 older people aged between 60 and 101, with an average age of (74.79 ± 8.58) at baseline, were included in the analysis. By 2020, there had been 447 deaths with mortality at 36.9% (447/1,213); there were 271 cases of diabetes, with a prevalence of 22.3% (271/1,213). The mean FI value for older adults with diabetes was higher than that of those without regardless of age, and the average annual relative growth rate of the FI value for older adults with diabetes was higher than that of those without diabetes (β = 0.039 vs. β = 0.035, t = 8.367, P &lt; 0.001). For all FI value levels, the mortality rate among older adults with diabetes was higher than that of those without. The Cox Regression analysis showed that, compared with those suffering from neither diabetes nor frailty, older adults with both had the higher mortality risk (HR = 1.760. P &lt; 0.001), followed by older adults suffering from frailty alone (HR = 1.594, P = 0.006), and then by older adults suffering from only diabetes (HR = 1.475, P = 0.033). The survival analysis showed that the median survival of those suffering from diabetes and frailty to be the shortest at just 57.23 (95% CI: 54.05 to 60.41) months, lower than the 83.78 (95% CI: 79.33 to 88.23) months in those suffering from frailty alone, and 119.93 (95% CI: 113.84 to 126.02) months in those with only diabetes, and 124.39 (95% CI: 119.76 to 129.02) months in older adults with neither diabetes nor frailty (P &lt; 0.001).ConclusionFrailty is common among older adults suffering from diabetes, and there is an increased risk of poor health outcomes, such as death, among older adults suffering from diabetes and frailty. When diagnosing, treating, and dealing with older adults with diabetes, attention should be paid to screening and assessing frailty in hopes of identifying it early so that appropriate measures of intervention can be taken to avoid or delay the resulting adverse effects.
Combined model of radiomics and clinical features for differentiating pneumonic-type mucinous adenocarcinoma from lobar pneumonia: An exploratory study
Authors: Ji Huijun , Liu Qianqian , Chen Yingxiu , Gu Mengyao , Chen Qi , Guo Shaolan , Ning Shangkun , Zhang Juntao , Li Wan-Hu 
Published: January 2023

PurposeThe purpose of this study was to distinguish pneumonic-type mucinous adenocarcinoma (PTMA) from lobar pneumonia (LP) by pre-treatment CT radiological and clinical or radiological parameters.MethodsA total of 199 patients (patients diagnosed with LP = 138, patients diagnosed with PTMA = 61) were retrospectively evaluated and assigned to either the training cohort (n = 140) or the validation cohort (n = 59). Radiomics features were extracted from chest CT plain images. Multivariate logistic regression analysis was conducted to develop a radiomics model and a nomogram model, and their clinical utility was assessed. The performance of the constructed models was assessed with the receiver operating characteristic (ROC) curve and the area under the curve (AUC). The clinical application value of the models was comprehensively evaluated using decision curve analysis (DCA).ResultsThe radiomics signature, consisting of 14 selected radiomics features, showed excellent performance in distinguishing between PTMA and LP, with an AUC of 0.90 (95% CI, 0.83–0.96) in the training cohort and 0.88 (95% CI, 0.79–0.97) in the validation cohort. A nomogram model was developed based on the radiomics signature and clinical features. It had a powerful discriminative ability, with the highest AUC values of 0.94 (95% CI, 0.90–0.98) and 0.91 (95% CI, 0.84–0.99) in the training cohort and validation cohort, respectively, which were significantly superior to the clinical model alone. There were no significant differences in calibration curves from Hosmer–Lemeshow tests between training and validation cohorts (p = 0.183 and p = 0.218), which indicated the good performance of the nomogram model. DCA indicated that the nomogram model exhibited better performance than the clinical model.ConclusionsThe nomogram model based on radiomics signatures of CT images and clinical risk factors could help to differentiate PTMA from LP, which can provide appropriate therapy decision support for clinicians, especially in situations where differential diagnosis is difficult.
The distribution, magnitude, and endemic species of US springs
Authors: Work Kirsten 
Published: January 2023

Freshwater springs and other groundwater-dependent ecosystems represent important natural resources in landscapes, providing consistent, high-quality water to both freshwater and terrestrial organisms. However, spring and GDE conservation does not appear to be a prominent feature on the US conservation radar. Therefore, this study evaluated the distribution and size of springs in the US with the national water dataset: the US Geological Survey National Water Information System. Using all available measurements of spring discharge and the sampling dates for all springs with data in the dataset (10,279 springs), I compared the number and sizes of springs between states and, where time series were available, determined whether the springs were maintaining historic discharges. I evaluated data quality using the date of the last sampling, number of times sampled, and the length of time sampled for each spring. Finally, I searched the literature for spring endemic species and recorded the states in which they occurred. Within the database, springs were most abundant in western states, but average discharges were largest for states in the southeast and for Idaho and Alaska. Very large springs occurred in some western states, but the multitudes of tiny springs reduced the average discharges. The data were poorly resolved as many of the springs had been sampled only once, often 40–50 years ago. Time series were available only for 126 springs and half of these springs exhibited declines in discharge. Endemic species were mentioned in the literature for 24 states, particularly those in the lower half of the country, and so loss of spring integrity would threaten biodiversity in many states. Due to the poor resolution of the data, broad conclusions about the integrity of these important freshwater systems are difficult to impossible to make for most states using the national dataset. Therefore, I call for a concerted national effort to more broadly evaluate spring and GDE resources. Springs and GDEs are likely to become even more important in the future as climate changes and their roles as freshwater refuges, temperature buffers, and bellwethers become even more important.
RETRACTED: Health risks and respiratory intake of submicron particles in the working environment: A case study
Authors: Gao Xiangjing , Zou Hua , Chen Rui , Fang Huanghong , Cao Yiyao , Hu Yong , Luan Yuqing , Yuan Weiming , Quan Changjian , Zhou Zanrong , Lou Xiaoming , Zhou Xingfan 
Published: January 2023

Background: Powder-coating processes have been extensively used in various industries. The submicron particles generated during the powder-coating process in the workplace have complex compositions and can cause serious diseases. The purpose of this study was to better understand the health risks and respiratory intake of submicron particles during the powder coating process.Methods: The concentrations of and variations in submicron particles were measured using real-time instruments. The health risks of submicron particles were analyzed using the Stoffenmanager Nano model. A new computational fluid dynamics model was used to assess the respiratory intake of ultrafine particles (UFPs), which was indicated by the deposited dosage of UFPs in the olfactory area, nasal cavity, and lungs. The deposited doses of UFPs were used to calculate the average daily doses (ADDs) of workers, according to the method described by the Environmental Protection Agency.Results: The number concentration (NC), mass concentration, surface area concentration, personal NC, and lung-deposited surface area concentration of submicron particles were &gt;105 pt/cm3, 0.2–0.4 mg/m3, 600–1,200 μm2/cm3, 0.7–1.4 pt/cm3, and 100–700 μm2/cm3, respectively. The size distribution showed that the submicron particles mainly gathered between 30 and 200 nm. The health risk of submicron particles was high. Upon respiratory intake, most UFPs (111.5 mg) were inhaled into the lungs, a few UFPs (0.272 mg) were trapped in the nasal cavity, and a small minority of UFPs (0.292 mg) were deposited in the olfactory area. The ADD of male workers with 10 years of exposure in the olfactory area, nasal cavity, and lung were 1.192 × 10–3 mg/kg·d−1, 1.11 × 10–3 mg/kg·d−1, and 0.455 mg/kg·d−1, respectively.Conclusion: Owing to the high concentrations of submicron particles, the workers involved in the powder-coating process are at a high health risk. Moreover, the respiratory intake of UFPs by workers is high, which is suggested by the highly deposited dosage of UFPs in the lungs and the corresponding high ADD in workers. Control measures, including engineering control, management control, and personal protective equipment, must be improved for the protection of workers.