bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of pregnancy hormones on pain perception in the peripartum period: A narrative review
Authors: Malviya Amit K. , Gupta Anju , Kumar Vinay , Gupta Jasmeen , Deepika  , Khanna Puneet 
Published: February 2025

Abstract
Pregnancy is a period marked by significant hormonal fluctuations, which can influence pain perception. There are only a limited number of analgesic options that are considered safe for newborns and mothers. Understanding the impact of pregnancy hormones on pain sensitivity can be crucial for effective pain management during childbirth and the postpartum period. The literature shows encouraging evidence of the role of pregnancy hormones on pain modulation, with some studies suggesting a potential reduction in pain sensitivity. Studies have shown progesterone to be associated with reduced post-cesarean pain scores and anesthesia requirements, while oxytocin levels inversely correlated with post-cesarean pain severity in some studies. However, the overall evidence remains inconclusive, indicating a need for further research to elucidate the complex mechanisms underlying hormonal modulation of pain perception during pregnancy and postpartum accurately. This narrative review summarizes the available literature to provide insights into the mechanisms and role of pregnancy hormones including progesterone, estrogen, and oxytocin in pain modulation during pregnancy, delivery, and the peripartum period. Future research should focus on clarifying the mechanisms through which pregnancy hormones influence pain perception and identifying individual factors that may contribute to variability in pain sensitivity among pregnant individuals. Well-designed randomized controlled trials should be planned to evaluate the effect of hormonal therapy on pain modulation in the peripartum period. This knowledge would help to generate evidence and design pain management protocols for obstetric patients.
Management of Childhood Obesity Among School Girls With a Comprehensive Approach Using Bio-Physiological Parameters
Authors: Rajeswari S , Tamilselvi S , Perdita A. Helen Mary 
Published: February 2025

ABSTRACT

Background:
The incidence of overweight and obesity is significantly rising and constitutes a serious global issue. This will result in significant health consequences in the child’s later years. This study aims on a comprehensive strategy for managing childhood obesity among girls.

Methodology:
A study used quasi experimental research design. The study sample consists of 60 school girls (control group = 30 and experimental group = 30). The experimental group participants were given moderate to high intensity aerobic exercises. Instructions were given to the experimental group participants regarding using healthy foods The adherence to the diet was checked by telephonic conversation with the parents, once a week. The control group children were provided all the details after completing the study.

Results:
The intervention showed significant difference in weight (P< 0.001), BMI (P< 0.001), waist circumference (P < 0.001), total cholesterol (P = 0.015), and LDL (P = 0.039) in the experimental group. Additionally, HDL levels significantly increased in the experimental group (P = 0.011). No significant difference were observed in the control group.

Conclusion:
The childhood obesity can be controlled by effective and regular aerobic exercises and a healthy diet which need to be educated and reinforced by nurses during school health visits.
Comparative Analysis of Biomarkers in CAD: Evaluating Homocysteine, Lipid HS-CRP, Apo A, and ADMA
Authors: Singh Sonu Kumar , Jha Roshan Kumar , Ambad Ranjit S. , Jha Rakesh Kumar 
Published: February 2025

ABSTRACT

Introduction:
Coronary artery disease (CAD), resulting from the narrowing of coronary arteries that supply oxygen to the heart, poses a significant global health challenge.

Materials and Methods:
To compare the levels of homocysteine, lipid profile, lipid ratios, HS-CRP, ADMA, and apolipoproteins in CAD patients with controls, this chapter analyzes risk factors, biomarkers, and clinical traits linked to coronary artery disease (CAD) through a case–control study involving 200 participants (100 CAD cases and 100 controls). The investigation focuses on demographic variables, traditional risk factors (e.g., hypertension, smoking, alcohol intake), and essential biochemical markers such as lipid profiles, homocysteine, and emerging biomarkers like HS-CRP, ADMA, and apolipoproteins (Apo A1 and Apo B).

Results and Conclusion:
The findings underscore the interplay between traditional and emerging risk factors in CAD progression. LDL, homocysteine, and TC/HDL ratio emerge as robust predictors of CAD risk. The regression model’s high explanatory power (R² =97.2%) validates these indicators for effective risk assessment.
Effect of Dyslipidaemia and Metabolic Function in Coronary Heart Disease with Type 2 Diabetes Mellitus - In Tertiary Care Center
Authors: Singh Akansha , Ambad Ranjit S. , Jha Roshan Kumar 
Published: February 2025

ABSTRACT

Introduction:
T2DM is strongly associated with an increased prevalence of cardiovascular disease (CVD). It has been established that CVD is the main cause of mortality among patients with type 2 diabetes mellitus (T2DM) contributing to 80% of fatal outcomes. The consistent relationship between T2DM and CVD is well-established in observational studies, meta-analyses, and has an easily discernible biological mechanism.

Aim and Objectives:
This was a cross-sectional study consisting of 100 subjects of diabetic and non-diabetic with CHD attending medicine outpatient department (OPD).

Result and Conclusion:
The study highlights that diabetes significantly exacerbates the metabolic and cardiovascular risks in coronary heart disease (CHD) patients, affecting lipid profiles, glycemic control, and long-term survival. Effective management of these parameters is crucial to improving outcomes in diabetic CHD patients. Postoperative morbidity and early mortality were not substantially affected by diabetes; however, long-term survival in diabetic CHD patients was markedly diminished, highlighting the enduring effects of diabetes on cardiovascular health.
Study the Correlation between Serum Caspase-1, IL-10, HOMA-IR, FAI, Dyslipidemia, and Oxidative Stress Status in Women with Polycystic Ovary Syndrome (PCOS)
Authors: Gusain Neelam , Anjankar Ashish P. , Ambad Ranjit S. , Jha Roshan K. , Jha Rakesh 
Published: February 2025

ABSTRACT

Introduction:
Polycystic Ovary Syndrome (PCOS) is a major health concern for women worldwide, particularly those of childbearing age. PCOS is a common endocrine disorder that has widely known reproductive, metabolic, cardiovascular adverse effects that lead to significant morbidity. There is continued research into the nature of this disorder and still many gaps to fill in the understanding of the exact ways in which PCOS develops.

Materials and Methods:
This study aims to investigate this uncharted horizon of PCOS by analysing the association between serum Caspase-1, IL-10, and biochemical indices relative to insulin resistance (HOMA-IR), hyperandrogenism (FAI), dyslipidemia, and oxidative stress in our female population. It expands on the significance of inflammation and insulin resistance, together with dyslipidemia, in the advancement and signs and symptoms of PCOS. Given the dearth of research that has explored the relationship between Caspase-1 and IL-10 in Indian women with established PCOS, this research preserves a central position. Its goal to improve the knowledge of the disease’s inflammatory and metabolic mechanisms and promote biomarkers and therapeutic targets discovery. The preface to this work in emphasizing the desire to contribute to medical science in its capacity to treat disease patients, in arguing that interdisciplinary collaboration between biochemistry, endocrinology, and gynaecology to improve to patient care.

Expected Outcome:
Our goal is to reveal possible approaches to reduce the impact of PCOS to improve the outcomes of its diagnostic, treatment and preventive methodologies for millions of afflicted women.
Comparative Evaluation of Delta Plates and Two Miniplates for the Fixation of Mandibular Condyle Fractures: A Randomized Controlled Trial
Authors: Pathak Rishik Raj , Kumaran P. Satish , Chinoy Maeraj Zubair , Saxena Sanindhya 
Published: February 2025

Abstract

Introduction:
The optimal treatment approach for fractures of the mandibular condyle continues to spark debate within the medical community, though surgical intervention through open reduction and internal fixation has garnered increasing acceptance, largely propelled by innovations in osteosynthetic materials and techniques.

Aim:
This study aimed to compare the outcome of delta plates versus two miniplates for mandibular condyle fracture fixation.

Materials and Methods:
Sixty patients with subcondylar fractures were randomized into two groups: Group A (two miniplates) and Group B (delta plate). Patients were randomly assigned to either Group A or Group B using a computer-generated randomization sequence with a 1:1 allocation ratio. The allocation was concealed using sealed opaque envelopes opened only after patient enrollment. Evaluation parameters included mouth opening, occlusion status, operative time, and complications.

Results:
Baseline characteristics were similar between the two groups. The mean mouth opening was similar between the groups at most time points, with Group B (delta plate) showing slightly better outcomes at 3 months (35.87 mm vs. 33.73 mm). Intraoperative time was significantly less for delta plates (mean 16.03 min) compared to two miniplates (mean 24.16 min). Postoperative occlusion was comparable, with both the groups achieving 100% stability by 1 month. Complication rates were low and similar between the groups, with only 6.7% of patients experiencing minor wound dehiscence at 1 week, resolving by 1 month. Radiographic evaluation showed successful reduction and fixation in all cases, with no plate bending or screw loosening observed during the 6-month follow-up.

Conclusion:
Both delta plates and two miniplates are equally effective in managing subcondylar fractures. Delta plates offer the advantage of easier placement and reduced operative time.
Fear of Sympathy in Cancer Patients
Authors: Khudhair Farah Abdul-Khaliq , Ibrahim AKthar Khalil , Al-Mansouri Loma Ahmed Abdullah Ali 
Published: February 2025

Objectives: This research aimed to study the fear of sympathy among cancer patients and examine how it varies based on different factors, including gender, stage of the disease, and type of treatment. The study sought to understand how fear of sympathy affects patients’ emotional well-being and their ability to express or receive compassion.

Methods: The study was conducted on a sample of 385 male and female cancer patients, selected intentionally. The Fear of Sympathy Scale by Gilbert (2011), consisting of 38 items, was used as the primary assessment tool. The reliability of the scale was confirmed through retesting, with a stability coefficient of 0.732 and a Cronbach's alpha of 0.79.

Results: The findings indicated that cancer patients in the study experienced fear of sympathy. There were no statistically significant differences in fear of sympathy based on gender (male or female) or disease stage (first, second, or third). However, statistically significant differences were observed in favor of those undergoing joint treatment.

Conclusion: The study concluded that fear of sympathy, stemming from the painful experience of the disease, negatively affects patients’ self-compassion, leading to self-blame and emotional distress. Additionally, the fear of receiving sympathy from others makes patients feel weak and helpless, limiting their ability to express emotions toward others. Given the emotional burden of cancer, the study recommended enhancing psychological counseling services in oncology centers and hospitals to provide psychological and social support to cancer patients.
Allyl-Modified of Calix[4]resorcinarene Derivatives for HER2 Inhibition Agents: An In Silico Study
Authors: Fitria Anggit , Kurniawan Yehezkiel Steven , Ananto Agus Dwi , Jumina Jumina , Sholikhah Eti Nurwening , Pranowo Harno Dwi 
Published: February 2025

Breast cancer is one of the deathliest cancer diseases for women, with high mortality cases. Since breast cancer cells overexpressed HER2 receptors, a computerized structure-based screening was conducted to identify potential HER2 inhibitors as an anti-breast cancer agent. This method can investigate the potency of proposed compounds as potential protein inhibitors. Researchers were interested in studying some synthetic macromolecules, i.e., allyl-modified calix[4]resorcinarenes, through in silico studies as HER2 inhibitors using molecular docking studies. Prospective protein-ligand complexes for HER2 inhibition were further investigated by molecular dynamics simulations for 200 ns on different binding pockets. The allyloxycalix[4]resorcinarene derivative (5A) was identified as the most potential HER2 inhibitor through a computational approach, including molecular docking studies and molecular dynamics simulations. The HER2-5A complex was relatively stable during the 200 ns molecular dynamics run. In addition, the hydrogen bonds formed between blind docking and molecular dynamics simulations are almost unchanged for the HER2-5A complex. The HER2-5A formed with two crucial amino acid residues, i.e., Asp845 and Asn850. Moreover, the data of the molecular dynamics simulations of compounds 5A and 2A demonstrate the stability of both complexes in different binding sites of HER2. These computational results are preliminary data for further synthesis and in vitro evaluation.
«БІР БЕЛДЕУ, БІР ЖОЛ» ЖОБАСЫНЫҢ МӘДЕНИ-ГУМАНИТАРЛЫҚ АСПЕКТІЛЕРІ МЕН БАҒЫТТАРЫ
Authors: Устемирова А.О 
Published: February 2025

«Бір белдеу, бір жол» жобасы «Ұлы жібек жолы» маршруты бойынша жүзеге асатынын білеміз. Ұлы Жібек жолы халықаралық қатынастардың даму тарихында ерекше орын алады. Бұл әлемдік сауда артериясы ғана емес, сонымен қатар әртүрлі елдер арасындағы мәдениаралық коммуникативті диалогты қамтамасыз ететін дипломатиялық қатынастардың этикасы (арнасы) болды. Ұлы Жібек жолы әртүрлі халықтардың мәдени интеграциясы мен моральдық дамуы үшін рухани-этникалық және эстетикалық көпір деп аталды. Жібек жолы бойындағы мемлекеттердің тауарларына, біліміне және мәдениеттеріне үлкен қызығушылық туындады. Сондықтан Ұлы Жібек жолын дамыту адамзат тарихындағы ірі мәдени оқиға болып табылады. Жібек жолы ол өткен елдердің саяси, экономикалық және мәдени құрылымының қалыптасуына үлкен әсер етті. Жібек жолының басты артықшылықтарының бірі – бұл керуен жолдарының бойында орналасқан барлық елдер ұзақ тарихи кезең ішінде олардың арасында экономикалық, мәдени қатынастар дамыды. Ғылыми мақалада «Бір белдеу, бір жол» жобасының мәдени және ғылым-білім, гуманитарлық байланыстар орнатудағы рөлі мен маңызы талданған. «Бір белдеу, бір жол» жобасының аясындағы мемлекеттердің мәдени байланыстары мен туризм саласындағы өзара дамыту ынтымақтастығы, ғылым және білім беру саласы мен адам әлеуетін дамытуға бағытталған шараларды жүзеге асырудағы маңызды қадамдар зерделенді. Жоба аясындағы өндірістен бастап қаржыға дейін және инфрақұрылымдық жобалардан бастап қоршаған ортаны қорғауға дейінгі гуманитарлық салалардағы ілгерілеу әсері сарапталды. Сонымен қатар, Қытай мемлкетенің жоба аясында ұйымдастырып отырған мәдени байқаулары мен ғылым және білім саласына бөліп отырған гранттарының игерілуі мен маңызы зерттелді.
REVIEW OF RECENT STUDIES ON THE MODERNIZATION PROCESSES IN THE FIELD OF HIGHER EDUCATION AND SCIENCE IN THE MODERN SOCIETY OF CHINA
Authors: Sabigazina S. , Wu Airong 
Published: February 2025

This introductory article aims to: provide an initial review of literature related to the topic of research work; clarify the approaches employed by scholars for analyzing the phenomenon; explore the research gaps and possible ways ahead; outline the research work’s structure and the key features of each chapter. The modernization of China's higher education today is the result of the reform and opening policy. The unique experience of the rapid expansion of Chinese higher education over the last decade has attracted increasing attention from academic scholars both in China and abroad. In particular, it is clear that any change in the history of China, which is a strategic partner of our country, will have an impact on our country. That's why the issue is very important and relevant for us.
We study the works published at different times and focuses on their source value. The existing research in China and abroad mainly focuses on the background and conditions of higher education reform, existing problems and countermeasures, experience and reference of other countries' construction. We did this by systematizing and comparing a number of data according to our chosen topic.
WORLD SECURITY IN THE CONTEXT OF THE FORMATION OF A MULTIPOLAR SYSTEM OF INTERNATIONAL RELATIONS
Authors: Biali M. , Sembaeva Zh.S. 
Published: February 2025

This article analyzes the problems of world security in the context of the formation of a multipolar system of international relations taking place on the basis of changes in geopolitical conditions in the modern world. The Covid-19 pandemic has led to some global changes. One of them is the tendency of the multipolar system in international relations. In accordance with the changes taking place, political reality takes on a different look, faces new threats and leads to systemic instability. One of them is the issue of international security. One of the most important features of the multipolar system is its unpredictability, which is due to the fact that it takes place not only in world, but also in regional competition. The article shows that ensuring international security in a multipolar world is a long and complex process, where, in addition to measures to establish mutual understanding and cooperation between the main actors, it is also necessary to improve international institutions and mechanisms for resolving international conflicts. This article is based on the emergence and direction of the multipolar system, its close connection with the issue of security in international conflicts.
ПОЛИТИЧЕСКИЕ И ЭКОНОМИЧЕСКИЕ ПРЕОБРАЗОВАНИЯ В КАЗАХСКОЙ СТЕПИ НА ПРИМЕРЕ «УСТАВА СИБИРСКИХ КИРГИЗОВ» 1822 г.
Authors: Ши Юэ 
Published: February 2025

В статье показано, что Устав о Сибирских киргизах (1822), заложил основы политико-административной и экономической трансформации в Казахской Степи. Это Устав лег в основу Устава Оренбургских Киргизов (1824) и других важных законов, изданных в 1860-х годах. Устав о Сибирских киргизах (1822) разработан Михаилом Сперанским, государственным деятелем, генерал-губернатором Сибири в 1819–1821 гг. В статье показано историческое значение этого документа, предлагающего новую административную систему, включающую казахские элиты, чингизидов и нечингизидов, в качестве кадров местного управления. На основе первоисточников в статье показано, что по этому Уставу традиционная государственность в Казахской степи в виде ханского управления была ликвидирована и введено новое управление через внешние округа, Согласно новому нормативному документу в степи были учреждены округа, волости и аулы, что должно было упразднить прежнюю родовую систему управления. Устав предусматривал некоторые положения в целях перевода казахов на оседлый образ жизни. Например, каждый округ должен производить заготовку, доставку и продажу хлеба, поощрялось занятие земледелием, огородничеством, садоводством, пчеловодством и другими вопросами социального обеспечения, поощрялось занятие торговлей.
Устав определял юридические и гражданские права казахов, позволял казахам вступать в другое сословие, пользоваться пятилетней льготой и свободой от рекрутства, а также иметь недвижимую собственность. Устав 1822 года, с одной стороны, очертил схему степной бюрократии, с другой стороны, инициировал социально-экономическую политику, способствующую политической и экономической трансформация в Казахской степи и стал новаторским шагом в институциональной истории царского правления в Казахской степи.
КОНЦЕПТУАЛЬНЫЕ ОСНОВЫ ИССЛЕДОВАНИЯ ГЕОПОЛИТИЧЕСКИХ ПОДХОДОВ В ГУМАНИТАРНЫХ НАУКАХ
Authors: Кагазбаева Э. , Караулова А. 
Published: February 2025

В данной статье рассмотрены концептуальные основания геополитических подходов в гуманитарных науках, раскрыты основные теории и концепции геополитических представлений, ее истоки. В современной геополитике основной пласт исследований посвящен экономическим, культурным и другим компонентам, поскольку они стали выходить на передний план в международных отношениях. Анализируются теоретические основы геоэкономики и геокультуры как направления гуманитарных наук, сформировавшиеся в середине XX века. Выделяются их основные смысловые компоненты и термины. Показывается взаимосвязь геополитической парадигмы с геоэкономическим и геокультурным дискурсом. Особенность представленной работы состоит в том, что были рассмотрены исследования по геоэкономике и геокультуре китайских ученых. Важно подчеркнуть, что в противовес западным концепциям, китайские мыслители предлагают вместо цивилизационных конфликтов развивать теории цивилизационного диалога и основными приоритетами международных отношений провозглашаются взаимное обучение, понимание и интеграция различных цивилизаций. Геокультура сегодня выступает особым видом мягкой силы, будучи ключевым элементом совокупной мощи государства. Геокультура отображает тенденцию к разнообразию цивилизаций. Она динамично формирует мировой геополитический порядок, соединимый с разными цивилизациями и культурами, по принципу уважения различий между ними.
Концептуально сформировались геоэкономика и геокультура как новые формы геополитики, что позволило отойти от традиционного понимания геополитической географии и сделали геополитическое пространство общим для участия стран всего мира. Авторы приходят к выводу, что в современных условиях более актуальны экономические и «мягкие» методы воздействия, в этих условиях классическая геополитика трансформируется в глобальную геополитику.
ТРАНСФОРМАЦИЯ И ОСОБЕННОСТИ ВНЕШНЕПОЛИТИЧЕСКИХ ИНИЦИАТИВ ЯПОНИИ В РЕСПУБЛИКЕ КАЗАХСТАН
Authors: Нурсеитова Л.Д. , Ашинова Ж.Е. 
Published: February 2025

Аннотация: В данной статье рассматриваются исторические аспекты дипломатических отношений и тенденции развития политических инициатив между Республикой Казахстан и государством Япония. Когда Советский Союз распался и страны Средней Азии достигли суверенитета, Японское государство инициировало важные политические инициативы с целью установления политико-экономических связей. Например, можно привести в пример крупную политическую программу «региональная дипломатия Шелкового пути», «Центральная Азия + Япония», основные инициативы, направленные на превращение Центральной Азии, Афганистана и Юго - Западной Азии в «коридор мира и стабильности».
Основная актуальность статьи заключается в том, что изучается основная причина заинтересованности японского государства в странах Средней Азии. Кроме того, будут проанализированы основные аспекты трансформации политических инициатив и экономической помощи. Анализируется стремление Казахстана вывести сотрудничество с Японией на новый уровень стратегического партнерства. Всесторонне рассматривается, играет ли Казахстан роль инвестиционного и технологического хаба для японских компаний в регионе, является ли Казахстан средой, облегчающей работу японских инвесторов. Для Казахстана исследуется большой авторитет Японии в продвижении технологических реформ в промышленном секторе, основанных на политике диверсификации экономики.
В исследовании по данной теме используются комплексные теоретические методы исследования методы сравнения, дифференциации, обобщения, систематизации.