bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate adaptive loci revealed by seascape genomics corroborate phenotypic variation in heat tolerance of the coral Acropora millepora
Authors: Denis Hugo , Selmoni Oliver , Gossuin Hugues , Jauffrais Thierry , Butler Caleb C , Lecellier Gaël , Berteaux-Lecellier Véronique 
Published: June 2023

Abstract

One of the main challenges in coral reef conservation and restoration is the identification of coral populations resilient under global warming. Seascape genomics is a powerful tool to uncover genetic markers potentially involved in heat tolerance among large populations without prior information on phenotypes. Here, we aimed to assess the role of candidate heat associated loci identified using seascape genomics in driving the phenotypic response of Acropora millepora from New Caledonia to thermal stress. We subjected 7 colonies to a long-term ex-situ heat stress assay (4°C above the Maximum Monthly Mean) and investigated their physiological response along with their Symbiodiniaceae communities and genotypes. Despite sharing similar thermal histories and associated symbionts, these conspecific individuals differed greatly in their tolerance to heat stress. More importantly, the clustering of individuals based on their alleles at the candidate loci coincided with the phenotypic variation in heat tolerance. Colonies harboring a higher proportion of heat-associated alleles sustained on average lower mortality, higher Symbiodiniaceae/chlorophyll concentrations and photosynthetic efficiency under prolonged heat stress. Together these results support the relevance of seascape genomics to reveal candidate loci for heat adaptation in corals and develop predictive models of heat tolerance.
A primary research on male patients diagnosed as acute brucellosis with untargeted metabolomics technique
Authors: Li Qiang , Wang Qiong , Wang Jianling , Zhou Xin , Zhao Yanmei , Xue Hongmei , Li Jiquan , Chen Yangyang , Chao Jie , Zhao Zhijun , Qi Zhizhen 
Published: June 2023

Abstract
Background
Brucellosis is a worldwide zoonotic disease through the consumption of unpasteurized dairy products, inhalation of infected aerosolized particles, and direct or indirect contact with infected animals. A timely and accurate diagnosis is key to the clinical management of brucellosis.
Method
The study included 8 male brucellosis patients and 8 control subjects. The serum samples were analyzed using Ultra performance liquid chromatography/tandem mass spectrometry ( UPLC- MS/MS ). The structural identification of these different metabolites was performed by comparing the exact mass data, retention time, and corresponding MS/MS fragments with those of mzCloud, mzVault and MassList database. We applied univariate analysis to calculate the statistical significance.The metabolites with VIP > 1 and P-value < 0.05 and fold change(FC) ≥ 2 or FC ≤ 0.5 were considered to be differential metabolites.
Results
25 different metabolites were identified. 6 metabolites were down-regulated, and 19 metabolites were up-regulated. Different metabolites identified in positive ionizationmodewereL-Kynurenine, (3,4-Dimethoxyphenyl) acetic acid, D- Sphingosine, D-(+)-Proline, 2-Amino-1,3-octadecanediol, Kahweol, 2- Hydroxycinnamic acid, Kynurenic acid, 5-(tert-butyl)-2- methyl-N-(4-nitrophenyl) – 3-furamide, 2-chloro-6-(4- methoxypheno xy)benzonitrile, and 1,4- dihydroxyheptadec =-16-en-2-yl acetate; Different metabolites identified in negative ionization mode were Lignoceric acid, Pentacosanoic acid, Xanthine, L-Phenylalanine, D-(+)-Tryptophan, Oleoyl-L-α-lysophosphatidic acid, γ- Aminobutyric acid, L- Glutamic acid, Citric acid, 2-(1H-benzimidazol-2-yl)-3 -(1,3- benzodioxol − 5-yl) acrylonitrile, Perfluorooctanoic acid, 4-Hexylresorcinol, Sorbitan monopalmitate, and Deoxycholic acid.
Conclusion
There were existing the metabolic changes of male patients diagnosised as acute brucellosis, which were involved in tryptophan metabolism, glyoxylate and dicarboxylate metabolism,as well as biosynthesis and metabolism of amino acids .
Low frequency binaural beats in instrumental music affects verbal memory but not false recall
Authors: Tay Peter Kay Chai , Lin Jia Lin Cherie , Lam Yeow Hing Bradley , Pang Chu Hui , Ng Soo Inn Fidessa , Wong Samuel Shengmiao 
Published: June 2023

Abstract
Binaural beats (BB) are produced when pure tones of slightly different frequencies are presented to each ear and may have therapeutic effects such as reduced anxiety and improved memory. While the effect of BB on anxiety has been investigated extensively, few studies explored the effect of BB on verbal memory and false memory. In the current double-blinded study, we investigated how BB overlaid with instrumental music affect memory for a list of words. 151 undergraduate participants (23% males) were randomized into one of three conditions to listen to a 30-min soundtrack: music with BB (n = 52), music only (n = 52), or audiobook (n = 47). The participants studied a list of fifteen words followed by a filler task. After which, the participants recall as many words as they could in any order. Two different word lists were presented before and after the listening task. We observed that while participants did not differ in their verbal recall before the listening tasks across the three conditions, those who listened to the music with BB recalled fewer words compared to those who listened to the audiobook after the listening task. In addition, although a greater proportion of participants who listened to the music with BB soundtrack produced false recall (51.9%) compared to those who listened to the music-only (50.0%) and audiobook (42.6%), the relationship between soundtrack and false recall was not statistically significant. The current findings suggest that low frequency BB in the delta/theta ranges may attenuate verbal memory particularly when listeners are exposed to BB frequency.
Interatrial Shunt Devices in Management of Heart Failure: A Systematic Review and Meta-Analysis
Authors: Li Min , Yi Tieci , Fan Fangfang , Qiu Lin , Wang Zhi , Weng Haoyu , Ma Wei , Zhang Yan 
Published: June 2023

Abstract
Background
Recent studies have shown that interatrial shunt devices (ISDs) can improve cardiac function and exercise tolerance in people with heart failure (HF). In this systematic review and meta-analysis, we assessed the efficacy of ISDs in the treatment of HF.
Methods
The Medline, Cochrane Library, Embase, and PubMed databases were searched through to December 7, 2022, to identify clinical studies that evaluated the effect of ISDs on HF. The primary endpoint was change in left ventricular ejection fraction (LVEF). Secondary endpoints included left atrial volume index, left ventricular end-diastolic diameter, right ventricular diameter, and tricuspid annular plane systolic excursion. Clinical functional capacity, including the 6-minute walk distance, New York Heart Association functional class, and N-terminal pro-B-type natriuretic peptide level, were also evaluated.
Results
Six trials that included 182 individuals were included in the quantitative analysis. Pooled analyses showed that LVEF increased by a mean of 3.07% (95% confidence interval [CI] 0.30, 5.84; P = 0.03) after ISDs implantation. There was no significant change in left atrial volume index (mean difference [MD] -0.33 mL/m², 95% CI -4.80, 4.13; P = 0.88; I2 = 0), left ventricular end-diastolic diameter (MD -0.53 cm, 95% CI -1.58, 0.53; P = 0.33; I2 = 80%), right ventricular diameter (MD 1.40 mm, 95% CI -1.72, 4.51; P = 0.38; I2 = 36%), or tricuspid annular plane systolic excursion (MD 0.74 mm, 95% CI -0.49, 1.98; P = 0.24; I2 = 0) after ISDs implantation. The 6-minute walk distance, N-terminal pro-B-type natriuretic peptide level, and New York Heart Association functional class were improved.
Conclusions
An ISDs can increase LVEF in patients with HF. Studies in larger sample sizes and with longer follow-up times are needed to confirm our findings.
The Impact of Site Contexts in Increasing the Diversity of Architectural Concepts: Using Interactive Architectural Approach
Authors: Baper Salahaddin Yassen , Ismael Zhiman Khairi 
Published: June 2023

Abstract

This research has introduced an approach to better cognition of the architectural concepts based on the site context parameter. Hence, the research investigates the role of site context in enhancing architectural concepts. The research problem is formulated to search the similarity and differences of senior architects’ strategies, thus, searching for aspects that may create the diversity of architectural products become necessary. The reality is that site considerations have received progressively less attention in the professional practice of architecture over the past decades. Then, the research used a two-level method with several steps to case study which are 12 international cases of three iconic deconstructive architects (Eisenman, Koolhaas, and Hadid). This study concludes that creating a site context that supports the surrounding context can enrich the design concept and create unexpected results.
Life satisfaction was measured as part of a retrospective study that evaluated the quality of life following TAR bridging treatment for recurring abdominal bulges
Authors: Saad Hassan A , Riad Mohamed , Eid Kamal Rabie , Elsayed Rasha S , Baz Azza , Elsayed Ashraf Abdelmonem , Farid Mohamed I , Eraky Mohamed E , El-Taher Ahmed k 
Published: June 2023

Abstract
Purpose
It is difficult to repair a large complex recurrent hernia. TAR with anterior fascial re-approximation may not be possible because of more tissue loss, so we find that transverse abdominal muscle repair (TAR) with bridging is a suitable technique for such a condition. We aim to demonstrate the results of bridge works at our hospital after data collection
Methods.
Our patients were retrospectively matched from our institution board sheet, zagazig university hospital.
One Hundredred ninety-two patients were available between 2015 and 2019 for our investigation.
Aim of the work:
Although the results of TAR with the bridge are not better with multiple recurrent, the life quality is improved; our outcome interesting are the quality of life (HerQLes) and pain severity(PROMIS pain intensity 3a), and recurrence, based on physical examinations and CT scans,
Results.
In our study, 192 patients were involved. The defect width of a hernia was typically 26±8 centimeters. Incisional hernias were the majority (93%). Recurrent type (71%) had, (21%) had five repeated prior hernia surgeries
A total (of 70%) had data accessible. HerQLes rankings confirmed a regular enhancement in the postoperative restoration manner (26± 21, 44± 26, and 60±33 at six months to three years, respectively; P value (<0.001).
as did the PROMIS Pain Intensity 3a
scores (46±11 at baseline, 45±11 at 30-day follow-up, and 39±11 at ix months–3 years; P=0.001). At a mean follow-up at six months to three years, P = 0.001). A composite recurrence of 46% was detected shortly at a counseled follow-up of 20±10 months, mainly from patients reporting a "bulge" at the site.
Conclusion.
Synthetic mesh in bridging TAR repairs for patients with recurrent, complex hernias is associated with a higher rate of bulge perception but with improved quality of life. The preoperative cases must be discussed for the ideal decision
A global assessment of academic promotion criteria: What really counts?
Authors: Lim Boon Han , D'Ippoliti Carlo , Dominik Martin , Vermeir Koen , Chong Kok-Keong , Backes Michael , Palomo Ignacio , Molnar Andreea , Hernández-Mondragón Alma , Cruz Thomas Edison dela , Mondello Stefania , López-Vergès Sandra , Coussens Anna , Enany Shymaa , Kumar Pradeep , Jambrak Anet Režek , Siciliano Velia , Bhadra Anindita , Bassioni Ghada , Xuereb André , Bueso Yensi Flores 
Published: June 2023

Abstract

The assessment of research performance is widely seen as a vital tool in upholding the highest standards of quality, with selection and competition believed to drive progress. Specifically, academic institutions need to take critical decisions on hiring and promotion, while facing external pressure by also being subject to research assessment [1–4]. Here, we present the first truly global outlook to research assessment for career progression, based on 159 institutional and 37 national policies from a total of 55 countries, 60% of them being outside of Western Europe and North America. We not only investigated how frequently various promotion criteria are mentioned, but also carried out a statistical analysis to infer structural commonalities and differences across policies. We find that quantitative assessment metrics remain popular, in agreement with other more geographically-restricted studies [5–9], but they are not omnipresent. We find notable differences between the Global North and the Global South as well as between institutional and national policies, but less so between research disciplines. In particular, the preference for bibliometric indicators is more marked in low- and middle-income countries. While we see some variation, many promotion policies assume that specific career paths that become normative rather than fully embracing diversity. In turn, this restricts opportunities for researchers. Our results challenge current practice and have strategic implications for researchers, research managers, and national governments.
Deep learning can predict prognosis and endocrine therapy response in breast cancer patients from H&amp;E staining based on estrogen receptor signaling activity
Authors: Ng Chun Wai , Wong Kwong-Kwok 
Published: June 2023

Abstract
Estrogen receptor (ER) expression status has long been a main factor for endocrine therapy. Deep learning methods can predict ER expression status by hematoxylin-and-eosin (H&E) staining. Since ER signaling activity has been found to be prognostic and is related to endocrine therapy responsiveness, we determined whether deep learning methods and whole-slide H&E-stained images could be used to predict ER signaling activity to determine prognosis in patients with breast cancer. ER signaling activity was determined using the Hallmark Estrogen Response Early gene set from the Molecular Signature Database (MSigDB). The data were fed into ResNet50 with three additional fully connected layers to predict the ER signaling activity of the samples, with ER signaling activity higher than the quantile 0.5. The trained model predicted that ER+/HER2- breast cancer patients with higher ER signaling activity had longer disease-free survival (p = 0.00415) and disease-specific survival durations (p = 0.00887). In conclusion, a convolutional deep neural network can predict prognosis and endocrine therapy response in breast cancer patients based on ER signaling activity using whole-slide H&E-stained images of tumors.
Spontaneous shock waves in pulse-stimulated flocks of Quincke rollers
Authors: Zhang Bo , Glatz Andreas , Aronson Igor , Snezhko Alexey 
Published: June 2023

Abstract
Active matter demonstrates complex spatiotemporal self-organization not accessible at equilibrium and the emergence of collective behavior. Fluids comprised of microscopic Quincke rollers represent a popular realization of synthetic active matter. Temporal activity modulations, realized by modulated external electric fields, have been recently suggested as an effective tool to expand the variety and complexity of accessible dynamic states in active ensembles. Here, we report on the emergence of shock wave patterns composed of coherently moving particles energized by a pulsed electric field. The shock waves emerge spontaneously and move faster than the average particle speed. Combining experiments, theory, and simulations, we demonstrate that the shock waves originate from intermittent spontaneous vortex cores due to a vortex meandering instability. They occur when the rollers' translational and rotational decoherence times, regulated by the electric pulse durations, become comparable. The phenomenon does not rely on the presence of confinement, and multiple shock waves continuously arise and vanish in the ensemble. Our findings highlight the importance of the interaction timescales in the emergence of dynamic patterns under temporally modulated energy injection. The results may stimulate design strategies for reconfigurable self-assembled active architectures.
Statistical differences in selective profiles between H. sapiens and SARS-CoV-2 genomes discover double or single stranded DNA or RNA
Authors: Valenzuela Carlos Y 
Published: June 2023

Abstract

Background The neutral theory of evolution intended first to explain evolution mostly by drift. By and by neutralist added to random factors, purifying selection, selection with small coefficients and homologized selective neutral to selective equivalent alleles, making it indistinguishable from some models of the synthetic theory of evolution. Therefore, I developed a method to study neutral evolution by the distance to neutrality (randomness) of the distribution of the two bases of dinucleotides separated by 0, 1, 2…K nucleotide sites. The distance was the value of the chi-square test. This method informs on the adaptive nature of 5’-3’ polarity and of the double or single stranded structure of nucleic acids. The method obtains the significance matrix (chi-squares values) vs separations (K) of the deviations from neutrality of dinucleotides; it compares the selective profiles (significance order, sign of selection and selection coefficient) between parallel (Par) and antiparallel (a-Par) dinucleotides with their index dinucleotide. DNA complementarity defines Par and a-Par. The distances of selective profiles between the index-Par or Index-a-Par dinucleotides were compared between them and between the human chromosome 21 (HCh21, double stranded DNA) and SARS-CoV-2 (single stranded RNA).
Results In HCh21, the Index and a-Par dinucleotides present almost equal selective profile, while the Par dinucleotides differ from the Index profiles. In SARS-CoV-2, a-Par and Par dinucleotides differ from the Index dinucleotides. The test detects double or single stranded DNA or RNA. Double stranded DNA structure and 5’-3’ polarity are adaptive evolutionary traits in humans or SARS-CoV-2. Both genomes coincide in the most negatively selective dinucleotide whose bases are contiguous: CG. The agreement or disagreement of selective traits of genomes within a biotic community measured by this method offer a complementary approximation to studies on ecological relationships of communities with members of different taxa.
Conclusions These analyses show the possibility to detect single or double stranded DNA or RNA of organisms by a simple statistical test of their genomes, and offer a new tool to study ecological or evolutionary processes
Co-creation process of an intervention to implement a multiparameter point-of-care device in a Primary Healthcare setting for non-communicable diseases in Peru
Authors: Albitres-Flores Leonardo , Pérez-León Silvana , Bernabe-Ortiz Antonio , Tenorio-Mucha Janeth , Cardenas Maria Kathia , Vetter Beatrice , Safary Elvis , Gamboa Ricardo , Cordova Vicente , Gupta Reena , Moran Andrew , Beran David , Lazo-Porras Maria 
Published: June 2023

Abstract
Background
Point-of-care devices (POCT) are diagnostic tools that can provide quick and accurate results within minutes, making them suitable for diagnosing non-communicable diseases (NCDs). However, these devices are not widely implemented in healthcare systems and for this reason is relevant to understand the implementation process.
Aims
To describe the process and define a strategy to implement a multiparameter POCT for diagnosing and managing NCDs in a low- and middle- income country.
Methods
A descriptive and non-experimental study was conducted in one region of Peru (Tumbes) to design an intervention for implementing a multiparameter POCT. Two co-creation sessions were conducted involving three groups: community members, primary healthcare workers, and regional decision-makers. These sessions included activities to understand patient journeys in receiving care for NCDs, identify facilitators and barriers to POCT usage, and define an implementation strategy for POCT in both rural and urban settings. The research team analysed the data and summarized key topics for discussion after each session.
Results
A total of 78 participants were enrolled across the three groups. Among community members: 22.2% had only diabetes, 24.1% had only hypertension, and 18.5% had both diagnoses. In the patient journey, community members mentioned that it took at least three days to receive a diagnosis and treatment for an NCD. Most of the participants agreed that the POCT devices would be beneficial for their communities, but they also identified some concerns. The strategy for POCT implementation included healthcare workers training, POCT must be placed in the laboratory area and must be able to perform tests for glucose, glycated haemoglobin, cholesterol, and creatinine. Advertising about POCT should be displayed at the healthcare centres and the municipality using billboards and flyers.
Conclusions
The co-creation process was effective in developing strategies for the implementation of multiparameter POCT devices for NCDs, involving the participation of different groups of stakeholders inboth rural and urban settings in Peru.
A short communication on functional, rheological and extrusion properties of high protein fractions from pulses obtained by air-classification
Authors: Bresciani Andrea , Chiodaroli Giulia , Landers Michael , Müller Jens , Wiertz Jessica , Marti Alessandra 
Published: June 2023

Abstract

As animal-based foods have a large impact on the environment, plant-based meat analogous are now in the spotlight. Although protein concentrates/isolates from soy are the most used raw materials for meat analogues, some concerns about allergenicity, loss of biodiversity, and low sustainability of their production rise from their uses. In this context, high protein fractions (HPFs) obtained by air classification of pulse flours are here proposed as substitutes of protein concentrates. Thus, this work is aimed at understanding the aptitude of HPF from pulses to be transformed into meat analogous through high moisture extrusion (HME) process. Differences in functional and rheological properties among HPFs resulted in different HME properties and thus products with different appearance. Specifically, the foaming capacity of HPF from red lentil resulted in expansion at the end of the extruder creating a heterogeneous structure. While the unsuitability of HPF from chickpea to HME could be related to its high lipid content. On the contrary, HPF from both fava bean and yellow pea presented a fibrous structure.
Computer Vision-based Driver Fatigue Detection Framework with Personalization Threshold and Multi-feature Fusion
Authors: Li Xiaolei , Lin Hao , Yang Yanyan 
Published: June 2023

Abstract
This paper proposes a novel non-intrusive and computer vision-based framework for driver fatigue detection from the video. First, to improve the judging accuracyof the driver’s facial expressions, the personalized threshold is proposed insteadof the traditional average threshold. Secondly, in order to alleviate the impactof the lack of relevant public data on model training, the transfer learning isused to train the eye and mouth state classifier. Finally, to solve the problem oflow universality and accuracy of the driver fatigue detection caused caused byusing only one type of facial features, multiple features including appearance-based features and deep learning-based features are used to detect driver fatiguedriving. The experiment results indicate that our method achieves 92.21% F1score and 29 fps, and yields better performance than traditional methods on thepublic NTHU-DDD dataset.