bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adenovirus Meningoencephalitis and Neurocysticercosis Co-infection:
First Case from India
Authors: Dinkar Anju , Singh Jitendra , Bhavya J.  , Singh Swati , Kumar Nilesh , Kumar Kailash 
Published: March 2023

Background:
Adenovirus generally causes upper and lower respiratory tract infections. It is
common in children and occasionally in adults. Neurological involvement is rare, which may be mild
aseptic meningitis to potentially fatal acute necrotizing encephalopathy. Recently, viruses have been
reported increasingly to cause CNS infections. Viral aetiology typically varies with age.

Case Presentation:
Here, we report an unusual adenovirus meningoencephalitis with a co-infection of
neurocysticercosis in an immunocompetent adult patient. An 18-year-old healthy female student was
admitted with fever and headache for 11 days and progressive altered behaviour for 5 days, followed
by altered sensorium for 3 days. This variable and unusual presentation of adenoviral infection involving
CNS provoked diagnostic difficulties, but with the help of advanced diagnostics, especially molecular,
exact aetiology was detected. Even with the neurocysticercosis infection in this patient, the outcome
was not adversely affected.

Conclusion:
This unusual co-infection with a successful outcome is the first case of this type in literature.
Different Variants of SARS-CoV-2: A Comprehensive Review on Mutation
Patterns and Pathogenicity
Authors: Rizvi Fahmina , Khan Mohsin Ali , Ansari Waseem Ahmad , Ali Kajim , Khan Mohd. Aamish , Khan Mohammad Faheem 
Published: March 2023

Abstract:
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a single-stranded and positive-
sense RNA virus, is exhibiting a great degree of mutation acclimated to variable environments, posing
a great threat to human life, with numerous SARS-CoV-2 variants. This review aims to analyze
emerging strains of SARS-CoV-2, their mutational pattern, their impact on viral pathogenicity, and the
identification of the targets for the development of vaccines and therapeutics against the virus. SARSCoV-
2 consists of four structural protein codes viz, peplomer protein (S), an envelope protein (E), nucleoprotein
capsid (N), and matrix protein (M), that are involved in the ingression of the viral genome into the
host cell by interacting with the host cell receptor, i.e., human angiotensin-converting enzyme 2 (ACE2)
(only S protein is shown to bind to ACE-2 receptor). The review includes consequences of mutations-
D614G (pre-dominant mutation), E484K, N501Y, K417N, L452R, P681H, del69/70, del157/158,
Ins214EPE, and so forth, in alpha, beta, gamma, delta, omicron including other strains of SARS-CoV-2.
Mutations include substitution, deletion, and insertion of amino acids in the spike glycoprotein of the
SARS-CoV-2, resulting in antibody neutralization, immune escape, etc. As a consequence of modifications
in the nucleotide sequence of the viral genome code pushed on by exposure to various environments,
these new strains influence the pathogenicity of the virus.
Developing an e-Prehabilitation System of Care for Young Adults Diagnosed With Cancer: User-Centered Design Study
Authors: McCann Lisa , Hewitt Christopher , McMillan Kathryn A 
Published: March 2023

Background
A diagnosis of cancer in adolescence or young adulthood can pose many different and unique challenges for individuals, as well as their families and friends. Drawing on the concept of prehabilitation, the provision of high-quality, accessible, timely, reliable, and appropriate information, care, and support for young adults with cancer and their families is critical to ensure that they feel equipped and empowered to make informed decisions relating to their treatment and care. Increasingly, digital health interventions offer opportunities to augment current health care information and support provision. Co-designing these digital health interventions can help to ensure that they are meaningful and relevant to the patient cohort, thereby maximizing their accessibility and acceptability.

Objective
This study had 4 primary interlinked objectives: understand the support needs of young adults with cancer at the time of diagnosis, understand the potential role of a digital health solution to assist in the delivery of prehabilitation for young adults with cancer, identify appropriate technologies and technological platforms for a digital prehabilitation system of care, and develop a prototype for a digital prehabilitation system of care.

Methods
This was a qualitative study using interviews and surveys. Young adults aged 16 to 26 years diagnosed with cancer within the last 3 years were invited to participate in individual user-requirement interviews or surveys. Health care professionals specializing in the treatment and care of young adults with cancer and digital health professionals working in the industry were also interviewed or completed a survey. Consensus feedback interviews were conducted with 3 young adults and 2 health care professionals after the development of the first generation of the prototype app.

Results
In total, 7 individual interviews and 8 surveys were completed with young adults with a range of cancer diagnoses. Moreover, 6 individual interviews and 9 surveys were completed with health care professionals, and 3 digital health professionals participated in one-on-one interviews. A prototype app with the working name of Cancer Helpmate was developed based on these collective participant data. Overall, feedback from participants across the data collection activities suggests that the concept for the app was positive during these developmental stages. Further insightful ideas for the app’s future development were also identified.

Conclusions
Young adults with cancer and health care professionals are responsive to the need for more digitally driven services to be developed. Further development of an app such as Cancer Helpmate, which incorporates key features and functionalities directly informed by users, could help to augment the support provided to young adults with cancer.
Association Between Internet Searches Related to Suicide/Self-harm and Adolescent Suicide Death in South Korea in 2016-2020: Secondary Data Analysis
Authors: Choi Won-Seok , Han Junhee , Hong Hyun Ju 
Published: March 2023

Background
Previous studies have investigated the association between suicide and internet search volumes of terms related to suicide or self-harm. However, the results varied by people’s age, period, and country, and no study has exclusively investigated suicide or self-harm rates among adolescents.

Objective
This study aims to determine the association between the internet search volumes of terms related to suicide/self-harm and the number of suicides among South Korean adolescents. We investigated gender differences in this association and the time lag between the internet search volumes of the terms and the connected suicide deaths.

Methods
We selected 26 search terms related to suicide and self-harm among South Korean adolescents, and the search volumes of these terms for adolescents aged 13-18 years were obtained from the leading internet search engine in South Korea (Naver Datalab). A data set was constructed by combining data from Naver Datalab and the number of suicide deaths of adolescents on a daily basis from January 1, 2016, to December 31, 2020. Spearman rank correlation and multivariate Poisson regression analyses were performed to identify the association between the search volumes of the terms and the suicide deaths during that period. The time lag between suicide death and the increasing trend in the search volumes of the related terms was estimated from the cross-correlation coefficients.

Results
Significant correlations were observed within the search volumes of the 26 terms related to suicide/self-harm. The internet search volumes of several terms were associated with the number of suicide deaths among South Korean adolescents, and this association differed by gender. The search volume for “dropout” showed a statistically significant correlation with the number of suicides in all adolescent population groups. The correlation between the internet search volume for “dropout” and the connected suicide deaths was the strongest for a time lag of 0 days. In females, self-harm and academic score showed significant associations with suicide deaths, but academic score showed a negative correlation, and the time lags with the strongest correlations were 0 and –11 days, respectively. In the total population, self-harm and suicide method were associated with the number of suicides, and the time lags with the strongest correlations were +7 and 0 days, respectively.

Conclusions
This study identifies a correlation between suicides and internet search volumes related to suicide/self-harm among South Korean adolescents, but the relatively weak correlation (incidence rate ratio 0.990-1.068) should be interpreted with caution.
Psycholinguistic Determinants of the Attitude of Young People to the Time Perspective
Authors: Abakumova I. V. , Azarko E. M. , Komerova N. E. 
Published: March 2023

Introduction. A new reality, characterized by geopolitical tension, a ‘reliability crisis’ of information, which deprives a modern person of the possibility of anticipating future events, introduces a situation of uncertainty, which makes it especially relevant to study the attitude of young people to the time of life. The research of foreign and domestic scientists in the fi of psycholinguistics, ideas about the image of the future and attitudes to the time perspective are analyzed. The found absence of studies of psycholinguistic determinants of attitudes to the time perspective in boys and girls justified the novelty of the study.Purpose. Identification and description of students’ ideas about the time perspective.Materials and Methods. As a methodological tool, we have chosen the methodology Time Perspective Questionnaire by Zimbardo, Ideas About Lifetime unfinished sentences technique by I. V. Abakumova, E. M. Azarko and N. E. Komerova, and morphological analysis on the platform RusTXT.RU.Results. It was determined that the ideas about the time perspective consist of priority values; systems of personal meanings; mechanisms of self-assessment and self-control; reflexive awareness of the past; motivating desires and attitudes. Psycholinguistic analysis revealed linguistic and meaning constructs most often used by young people to describe attitudes to the past, present, and future. The author’s model of psycholinguistic determinants of attitude to time is presented.Discussion and Conclusion. The variability of a person’s attitude towards the past and the uniqueness of a person’s lexicon due to individual linguistic experience are emphasized. The high degree of orientation of students for the future is described. It is shown that the frequency of using certain parts of speech varies depending on the attitude to the time perspective. It was revealed that respondents with a high orientation to the future and a positive attitude to the past use more parts of speech to describe the past and the future. Their speech is characterized by greater specificity and vocabulary, which indicates the formation of ideas about life.
Collective Narcissism in Connection with the Students’ Personal Characteristics
Authors: Shabukaeva M. R. 
Published: March 2023

Introduction. Currently, the problem of collective narcissism is relevant, confirmed by many studies in this area. The ‘collective narcissism’ concept is broader than ‘personal narcissism’. It represents a person’s ability to endow a group with significance, emphasizing its importance and image, regardless of what religion, race, social class or status it belongs to. One of the unresolved problems at the moment is the identifi of personality determinants that strengthen collective narcissism.Purpose. The study aimed to identify the relationship of collective narcissism with various personal characteristics of students and the role of collective narcissism in these relationships. We hypothesized that group narcissism is interconnected with some respondents’ personal characteristics.Materials and Methods. The study used reliable and valid methods: Collective Narcissism, the Freiburg Personality Inventory (Form B), A Five Factor Personality Questionnaire and the Wiesbaden WIPPF questionnaire (Form A). The obtained data were subjected to correlation analysis according to Spearman’s test.Results. In our study, artistry, religiosity, pragmatism, extroversion, and attracting attention were associated with collective narcissism.Discussion and Conclusion. The authors draw attention to the problem associated with narcissism and how it manifests in different groups. In our study, it was possible to show the relationship between individual personality traits prevailing in a group of Dagestan students and the manifestation of collective narcissism, which was expressed to an average degree. The authors indicate the study limitation that involves a lack of consideration of the different national groups’ presence in the sample.
Designing a Personal Model for the Development of Professional Resilience of a Specialist in the Field of Social Orphanhood
Authors: Bayer E. A. , Zaluzhnaya M. V. , Gorbatkova O. I. , Illarionova A. Yu. 
Published: March 2023

Introduction. The study is relevant in the presentation of a new approach to the consideration of resilience. Resilience is defined as a professional personal quality of a specialist in the field of social orphanhood. The system of teacher training implies the formation of specific professional competencies. However, their level is checked only during difficult life situation occurrence and a specialist who does not have specific life experience resorts to meta-skills usage, the development of which the educational programme of the designated system does not provide. Based on the principles of purposeful continuous training of a resilient specialist under the conditions of the basic departments of Russian universities, it seems possible to strengthen human potential in the field of social orphanhood.Purpose. Determination of the mechanism of development of professional resilience of a specialist in the field of preventionof social orphanhood.Materials and Methods. Based on the concept of resilience in the field of social orphanhood (E. A. Bayer) a questionnaire was created for teachers and practitioners, consisting of 57 questions. The survey was attended by 72 specialists aged 25 to 60 years with professional experience ranging from 5 to 35 years.Results. Most of the specialists surveyed (76.4 %) started their professional career after graduating and made their choice intentionally. Examples of teacher behaviour that is unacceptable when communicating with students are identified. The ranking of primary professional competencies and special skills, cross-contextual and existential skills, meta-skills, and personality qualities significant for a new format university teacher was carried out.Discussion and Conclusion. The qualitative characteristics proposed by modern researchers confirm the urgent need for the development of resilience among specialists in the field of the prevention of social orphanhood.
SIFAT FISIK DAN TOTAL BAKTERI ASAM LAKTAT (BAL) YOGHURT DENGAN BAHAN BAKU SUSU SAPI YANG BERBEDA
Authors: Nugroho Muhammad Rafif , Wanniatie Veronica , Qisthon Arif , Septinova Dian 
Published: March 2023

Tujuan penelitian ini adalah untuk mengetahui pengaruh berbagai bahan baku susu sapi yang berbeda terhadap nilai total asam, pH, dan BAL yoghurt dan mengetahui bahan baku susu sapi olahan terbaik terhadap nilai pH, total asam, dan BAL yoghurt. Penelitian ini dilaksanakan pada Juni 2022 di Laboratorium Produksi dan Reproduksi Ternak, Jurusan Peternakan, Fakultas Pertanian, Universitas Lampung, dan Laboratorium Teknologi Hasil Pertanian, Politeknik Negri Lampung. Penelitian ini merupakan penelitian eksperimental dengan menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 3 perlakuan yaitu P1: susu pasteurisasi full cream, P2 : susu UHT full cream, P3 : susu bubuk full cream dengan 5 ulangan. Data yang diperoleh dianalisis dengan analisis of varian (ANOVA) dengan taraf 5% dan 1% dan dilanjutkan Beda Nyata Terkecil (BNT). Hasil penelitian terhadap uji total asam yoghurt tidak berpengaruh nayta (P>0,05) dengan nilai rata-rata perlakuan yaitu 0,73 % (P1); 0,66 % (P2); 0,63 % (P3). Pada analisis uji pH yoghurt menunjukkan hasil yang berpengaruh nyata (P<0,05) dengan nilai rata-rata perlakuan yaitu 4,20 (P1); 4,36 (P2); 4,46 (P3). Hasil analisis uji Bakteri Asam Laktat (BAL) yoghurt menunjukkan hasil berpengaruh nyata (P<0,05) dengan nilai rata-rata pada tiap perlakuan yaitu P1: 13,64x109 CFU/ml, P2: 1,98x109 CFU/ml, P3: 0,282x109 CFU/ml. Dari hasil penelitian disimpulkan bahwa perlakuan dengan berbagai bahan baku susu yang berbeda terhadap total asam laktat, pH dan bakteri asam laktat (BAL) yoghurt yaitu dengan bahan baku susu pasteurisasi full cream karena menunjukkan nilai yang mendekati Standar Nasional Indonesia (SNI) yoghurt.
The role of matrix metalloproteinases in pathogenesis, diagnostics, and treatment of human prostate cancer
Authors: Wiśniowski Tomasz , Bryda Jarosław , Wątroba Sławomir 
Published: March 2023

Abstract
The prostate gland is highly susceptible to oncogenic transformation, many times more than other sex tissues, such as seminal vesicles. In fact, prostate cancer (PCa) will be diagnosed in one in seven lifetime patients, making PCa the subject of intense research aimed at clarifying its biology and providing adequate treatment. PCa is the fourth most common cancer in the world in terms of the overall population and the second most common cancer for the male population. It is postulated that the development of PCa may be influenced by dietary factors, physical and sexual activity, androgens, obesity, and inflammation, but their role in the development of prostate cancer still remains unclear. Extracellular matrix metalloproteinases (MMPs) and tissue metalloproteinase inhibitors (TIMPs) play an important role in many physiological and pathological processes, including proliferation, migration, invasion, cell differentiation, participation in inflammatory processes and angiogenesis. Numerous studies point to a direct relationship between MMPs and both local tumor invasion and the formation of distant metastases. High activity of MMPs is observed in solid tumors of various origins, which positively correlates with a poor overall survival rate. Although biochemical diagnostic markers of PCa are currently available, from the point of view of clinical practice, it seems particularly important to develop new and more sensitive markers allowing for early diagnosis and long-term monitoring of patients after PCa treatment, and the assessment of MMP activity in urine and serum of patients are potential factors that could play such a role.
Reformulation of Children’s Restitution to Guarantee Their Constitutional Rights
Authors: Pratama Andre Arya 
Published: March 2023

Children as victims of criminal acts of sexual violence essentially need to get the protection of the welfare and the right to return to grow and develop in accordance with the 1945 Constitution. Losses suffered by children need to be claimed through criminal compensation to the perpetrator or third person, namely the submission of the right to restitution. The mechanism for filing the right to restitution has certainly developed in the rule of law. However, until now it is still an obstacle for victims in fulfilling the filing requirements based on Government Regulation Number 43 of 2017. Of course this will make it difficult for victims to get justice as they should. This article will use normative research, where this research describes the analysis of the problems presented in the research using laws and regulations that refer to Law Number 31 of 2014 and Government Regulation Number 43 of 2017 in accordance with the scope of the discussion of applicable law and comes from literature journals and other sources of information that become references for the author to collect data to complete this research. The results show that the mechanism for implementing the right to restitution is difficult to implement, especially considering that victims tend to be unfamiliar with the law, besides that there are still perpetrators who generally come from the closest family and are not capable and have not regulated the nominal amount of payment that the perpetrator must fulfill. Therefore, it is necessary to reformulate the applicable regulations and related institutions need to play an active role in facilitating victims to fulfill the rights that should be obtained from a criminal offense as a form of effort to realize Human Rights (HAM) itself in the constitutional guarantees of citizens, especially children.
OS EFEITOS DA PANDEMIA NO BEM-ESTAR DOS ENFERMEIROS BRASILEIROS NO COMBATE AO COVID-19: UMA REVISÃO DE ESCOPO
Authors: Da Silva Junior Milton Domingues , Da Silva Roni Robson , Santos Maria Isabel Silva , Ferreira Ana Rita Alves , Passos Joanir Pereira 
Published: March 2023

Introdução: Estudos indicam que os profissionais de saúde têm alto risco de desenvolver sintomas relacionados à saúde mental, especialmente depressão, ansiedade e estresse. Objetivo: identificar e sintetizar os estudos sobre os preditores relacionados a saúde mental entre enfermeiros que atuam na linha de frente no combate ao COVID-19. Método: Trata-se de uma revisão de escopo, sem limitação de linguagem e ano, nas bases BVS, PubMed, SCIELO, CINAHL, SCOPUS, Web of Science, MedNar, CAPES e ProQuest. Foi realizada síntese narrativa. Resultados: A pandemia da COVID-19 trouxe sérios impactos a saúde mental dos profissionais de enfermagem, os achados revelaram cinco temas principais sentimento de insegurança, falta de equipamentos de proteção individual, falta de exames diagnósticos, mudanças no fluxo de atendimento e medo do desconhecido. Existe uma associação significativa entre o bem-estar físico e metal e a produtividade laboral. Conclusão: Destaca-se os desafios enfrentados pelos enfermeiros no combate da COVID-19, mesmo com a repercussões no ambiente de trabalho os enfermeiros ainda padecem de reconhecimento adequado que incluem situações de estresse, ansiedade, depressão e estão diretamente relacionadas à frustração, esgotamento físico e mental, sentimento de impotência e insegurança profissional vivenciados durante a pandemia, principalmente por jovens profissionais sem experiência no cuidado de pacientes críticos.