bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges in, and recommendations for, hyperspectral imaging in ex vivo malignant glioma biopsy measurements
Authors: Walke Anna , Black David , Valdes Pablo A. , Stummer Walter , König Simone , Suero-Molina Eric 
Published: April 2023

AbstractThe visualization of protoporphyrin IX (PPIX) fluorescence with the help of surgical microscopes during 5-aminolevulinic acid-mediated fluorescence-guided resection (FGR) of gliomas is still limited at the tumor margins. Hyperspectral imaging (HI) detects PPIX more sensitively but is not yet ready for intraoperative use. We illustrate the current status with three experiments and summarize our own experience using HI: (1) assessment of HI analysis algorithm using pig brain tissue, (2) a partially retrospective evaluation of our experience from HI projects, and (3) device comparison of surgical microscopy and HI. In (1), we address the problem that current algorithms for evaluating HI data are based on calibration with liquid phantoms, which have limitations. Their pH is low compared to glioma tissue; they provide only one PPIX photo state and only PPIX as fluorophore. Testing the HI algorithm with brain homogenates, we found proper correction for optical properties but not pH. Considerably more PPIX was measured at pH 9 than at pH 5. In (2), we indicate pitfalls and guide HI application. In (3), we found HI superior to the microscope for biopsy diagnosis (AUC = 0.845 ± 0.024 (cut-off 0.75 µg PPIX/ml) vs. 0.710 ± 0.035). HI thus offers potential for improved FGR.
Parasitic infection in the scyphozoan Rhizostoma pulmo (Macri, 1778)
Authors: Motta Gregorio , Caffara Monica , Fioravanti Maria Letizia , Bottaro Massimiliano , Avian Massimo , Terlizzi Antonio , Tedesco Perla 
Published: April 2023

AbstractVery little information is reported for parasites of cnidarians, therefore, the present work aimed to investigate parasitic infections in one of the most widespread jellyfish in the Mediterranean Sea, Rhizostoma pulmo. The goals were to determine prevalence and intensity of parasites in R. pulmo, identify the species involved through morphological and molecular analysis, test whether infection parameters differ in different body parts and in relation to jellyfish size. 58 individuals were collected, 100% of them infected with digenean metacercariae. Intensity varied between 18.7 ± 6.7 per individual in 0–2 cm diameter jellyfish up to 505 ± 50.6 in 14 cm ones. Morphological and molecular analyses suggest that the metacercariae belonged to the family Lepocreadiidae and could be possibly assigned to the genus Clavogalea. Prevalence values of 100% suggest that R. pulmo is an important intermediate host in the life cycle of lepocreadiids in the region. Our findings also support the hypothesis that R. pulmo is an important part in the diet of teleost fish, which are reported as definitive hosts of lepocreadiids, since trophic transmission is necessary for these parasites to complete their life cycles. Parasitological data may therefore be useful to investigate fish-jellyfish predation, integrating traditional methods such as gut contents analysis.
Treatment with fibroblast growth factor 19 increases skeletal muscle fiber size, ameliorates metabolic perturbations and hepatic inflammation in 5/6 nephrectomized mice
Authors: Benoit Berengère , Beau Alice , Bres Émilie , Chanon Stéphanie , Pinteur Claudie , Vieille-Marchiset Aurélie , Jalabert Audrey , Zhang Hao , Garg Priyanka , Strigini Maura , Vico Laurence , Ruzzin Jérôme , Vidal Hubert , Koppe Laetitia 
Published: April 2023

AbstractChronic kidney disease (CKD) is associated with osteosarcopenia, and because a physical decline in patients correlates with an increased risk of morbidity, an improvement of the musculoskeletal system is expected to improve morbi-mortality. We recently uncovered that the intestinal hormone Fibroblast Growth Factor 19 (FGF19) is able to promote skeletal muscle mass and strength in rodent models, in addition to its capacity to improve glucose homeostasis. Here, we tested the effects of a treatment with recombinant human FGF19 in a CKD mouse model, which associates sarcopenia and metabolic disorders. In 5/6 nephrectomized (5/6Nx) mice, subcutaneous FGF19 injection (0.1 mg/kg) during 18 days increased skeletal muscle fiber size independently of food intake and weight gain, associated with decreased gene expression of myostatin. Furthermore, FGF19 treatment attenuated glucose intolerance and reduced hepatic expression of gluconeogenic genes in uremic mice. Importantly, the treatment also decreased gene expression of liver inflammatory markers in CKD mice. Therefore, our results suggest that FGF19 may represent a novel interesting therapeutic strategy for a global improvement of sarcopenia and metabolic complications in CKD.
Flood sensitivity assessment of super cities
Authors: Wang Zijun , Chen Xiangyu , Qi Zhanshuo , Cui Chenfeng 
Published: April 2023

AbstractIn the context of global urbanization, more and more people are attracted to these cities with superior geographical conditions and strategic positions, resulting in the emergence of world super cities. However, with the increasing of urban development, the underlying surface of the city has changed, the soil originally covered with vegetation has been substituted by hardened pavement such as asphalt and cement roads. Therefore, the infiltration capacity of urban rainwater is greatly limited, and waterlogging is becoming more and more serious. In addition, the suburbs of the main urban areas of super cities are usually villages and mountains, and frequent flash floods seriously threaten the life and property safety of people in there. Flood sensitivity assessment is an effective method to predict and mitigate flood disasters. Accordingly, this study aimed at identifying the areas vulnerable to flood by using Geographic Information System (GIS) and Remote Sensing (RS) and apply Logistic Regression (LR) model to create a flood sensitivity map of Beijing. 260 flood points in history and 12 predictors [elevation, slope, aspect, distance to rivers, Topographic Wetness Index (TWI), Stream Power Index (SPI), Sediment Transport Index (STI), curvature, plan curvature, Land Use/Land Cover (LULC), soil, and rainfall] were used in this study. Even more noteworthy is that most of the previous studies discussed flash flood and waterlogging separately. However, flash flood points and waterlogging points were included together in this study. We evaluated the sensitivity of flash flood and waterlogging as a whole and obtained different results from previous studies. In addition, most of the previous studies focused on a certain river basin or small towns as the study area. Beijing is the world's ninth largest super cities, which was unusual in previous studies and has important reference significance for the flood sensitivity analysis of other super cities. The flood inventory data were randomly subdivided into training (70%) and test (30%) sets for model construction and testing using the Area Under Curve (AUC), respectively. The results turn out that: (1) elevation, slope, rainfall, LULC, soil and TWI were highly important among these elements, and were the most influential variables in the assessment of flood sensitivity. (2) The AUC of the test dataset revealed a prediction rate of 81.0%. The AUC was greater than 0.8, indicating that the model assessment accuracy was high. (3) The proportion of high risk and extremely high risk areas was 27.44%, including 69.26% of the flood events in this study, indicating that the flood distribution in these areas was relatively dense and the susceptibility was high. Super cities have a high population density, and once flood disasters occur, the losses brought by them are immeasurable. Thus, flood sensitivity map can provide meaningful information for policy makers to enact appropriate policies to reduce future damage.
Stroke Care Pathway ensures high-quality stroke management in the COVID-19 pandemic
Authors: Mayer-Suess Lukas , ter Telgte Annemieke , Praxmarer Silvia , Willeit Johann , Wöll Ewald , Geley Theresa , Rinner Heinrich , Knoflach Michael , Kiechl Stefan ,   The Tyrolean Stroke Pathway Group, Maurer Andreas , Schinnerl Adolf , Rauter-Rzehak Alexandra , Tür Andreas , Oberwinkler Bernhard , Dengg Christian , Loidl Patrick , Schoenherr Gudrun , Seiwald Gudrun , Kreuzer Hans , Schoenherr Hans-Robert , Matzak Heinrich , Spiss Heinrich , Kathrein Hermann , Gänzer Hannes , Schöch Johannes , Grossmann Josef , Runge Julia , Willeit Karin , Boehme Christian , Klingenschmid Gerhard , Toell Thomas , Pechlaner Raimund , Hametner Eva , Schmidauer Christoph , Sojer Martin , Berek Klaus , Engelhardt Klaus , Mayr Markus , Baubin Michael , Kaiser Norbert , Perfler Robert , Erlacher Thomas , Fluckinger Thomas , Grander Wilhelm 
Published: April 2023

AbstractThe aim of our study was to assess whether a well-established federal state-wide Stroke Care Pathway delivering high quality stroke care can cope with the COVID-19 pandemic and associated measures to contain the virus spread. The retrospective analysis is based on a prospective, quality-controlled, population-based registry of all stroke patients in the Tyrol, a federal state of Austria and one of the early hot-spots of COVID-19 in Europe. Patient characteristics, pre-hospital management, intra-hospital management and post-hospital were analysed. All residents of the Tyrol suffering ischemic stroke in 2020 (n = 1160) and four pre-COVID-19 years (n = 4321) were evaluated. In 2020, the annual number of stroke patients was the highest in this population-based registry. When local hospitals were overwhelmed with SARS-CoV-2-patients, stroke subjects were temporarily allocated to the comprehensive stroke centre. Stroke severity, quality metrics of stroke management, serious complications, and post-stroke mortality did not differ between 2020 and the four comparator years. Notably, iv. thrombolysis-rate was similar (19.9% versus 17.4%, P = 0.25) and endovascular stroke treatment even better (5.9% versus 3.9%, P = 0.003) but resources for in-patient rehabilitation were limited (25.8% versus 29.8%, P = 0.009). Concluding, a well-established Stroke Care Pathway was able to maintain high-quality acute stroke care even when challenged by a global pandemic.
Predicting wellbeing over one year using sociodemographic factors, personality, health behaviours, cognition, and life events
Authors: Chilver Miranda R. , Champaigne-Klassen Elyse , Schofield Peter R. , Williams Leanne M. , Gatt Justine M. 
Published: April 2023

AbstractVarious sociodemographic, psychosocial, cognitive, and life event factors are associated with mental wellbeing; however, it remains unclear which measures best explain variance in wellbeing in the context of related variables. This study uses data from 1017 healthy adults from the TWIN-E study of wellbeing to evaluate the sociodemographic, psychosocial, cognitive, and life event predictors of wellbeing using cross-sectional and repeated measures multiple regression models over one year. Sociodemographic (age, sex, education), psychosocial (personality, health behaviours, and lifestyle), emotion and cognitive processing, and life event (recent positive and negative life events) variables were considered. The results showed that while neuroticism, extraversion, conscientiousness, and cognitive reappraisal were the strongest predictors of wellbeing in the cross-sectional model, while extraversion, conscientiousness, exercise, and specific life events (work related and traumatic life events) were the strongest predictors of wellbeing in the repeated measures model. These results were confirmed using tenfold cross-validation procedures. Together, the results indicate that the variables that best explain differences in wellbeing between individuals at baseline can vary from the variables that predict change in wellbeing over time. This suggests that different variables may need to be targeted to improve population-level compared to individual-level wellbeing.
Connectome and regulatory hubs of CAGE highly active enhancers
Authors: Briend Mewen , Rufiange Anne , Moncla Louis-Hippolyte Minvielle , Mathieu Samuel , Bossé Yohan , Mathieu Patrick 
Published: April 2023

AbstractEvidence indicates that enhancers are transcriptionally active. Herein, we investigated transcriptionally active enhancers by using cap analysis of gene expression (CAGE) combined with epigenetic marks and chromatin interactions. We identified CAGE-tag highly active (CHA) enhancers as distant regulatory elements with CAGE-tag ≥ 90th percentile and overlapping with H3K27ac peaks (4.5% of enhancers). CHA enhancers were conserved between mouse and man and were independent from super-enhancers in predicting cell identity with lower P-values. CHA enhancers had increased open chromatin and a higher recruitment of cell-specific transcription factors as well as molecules involved in 3D genome interactions. HiChIP analysis of enhancer-promoter looping indicated that CHA enhancers had a higher density of anchor loops when compared to regular enhancers. A subset of CHA enhancers and promoters characterized by a high density of chromatin loops and forming hub regulatory units were connected to the promoter of immediate early response genes, genes involved in cancer and encoding for transcription factors. Promoter of genes within hub CHA regulatory units were less likely to be paused. CHA enhancers were enriched in gene variants associated with autoimmune disorders and had looping with causal candidate genes as revealed by Mendelian randomization. Hence, CHA enhancers form a dense hierarchical network of chromatin interactions between regulatory elements and genes involved in cell identity and disorders.
Accuracy of pilot balloon palpation for cuff pressure assessment in small versus large sized tubes: a prospective non-randomized observational study
Authors: Ban Min Gi , Kim So Yeon , Kim Min Soo , Park Wyun Kon , Kwon Young In , Kim Hyun Joo 
Published: April 2023

AbstractPilot balloon palpation is still a commonly used method to evaluate cuff pressure of the endotracheal tube after intubation. This study determined whether the size of the tracheal tube influenced the accuracy of pilot balloon palpation. A prospective observational analysis of 208 patients intubated with an endotracheal tube of internal diameter (ID) 6.0 or 8.0 was conducted. An anesthesiologist judged the cuff pressure by manual pilot balloon palpation, and then measured the cuff pressure with a pressure gauge. Cuff pressure exceeding 20–30 cmH2O was defined as false recognition. The intracuff pressure was significantly higher in ID 6.0 tube than in the ID 8.0 tube (41.9 ± 18.8 cmH2O vs. 30.3 ± 11.9 cmH2O, p < 0.001). The number of patients that were mistakenly perceived to have appropriate cuff pressure by pilot balloon palpation was significantly higher in the ID 6.0 group compared to the ID 8.0 group (85 (81.7%) vs. 64 (61.5%), p = 0.001). Therefore, a smaller tube size may further increase risk of inaccurate measurement by pilot balloon palpation and although pressure gauge is recommended for all sizes to maximize accuracy, groups with increased risk factors should be targeted for standardized use of the pressure gauge.
Serum proteins for monitoring and predicting visual function in patients with recent optic neuritis
Authors: Kim Hyo Jae , Lee Eun-Jae , Kim Sang-Yeob , Kim Hyunjin , Kim Keon-Woo , Kim Seungmi , Kim Hyunji , Seo Dayoung , Lee Byung Joo , Lim Hyun Taek , Kim Kwang-Kuk , Lim Young-Min 
Published: April 2023

AbstractIt is unclear whether serum proteins can serve as biomarkers to reflect pathological changes and predict recovery in inflammation of optic nerve. We evaluated whether serum proteins could monitor and prognosticate optic neuritis (ON). We prospectively recruited consecutive patients with recent ON, classified as ON with anti-aquaporin-4 antibody (AQP4-ON), ON with anti-myelin oligodendrocyte glycoprotein antibody (MOG-ON), and double-seronegative ON (DSN-ON). Using ultrasensitive single-molecule array assays, we measured serum neurofilament light chain and glial fibrillary acidic protein (GFAP), and brain-derived neurotrophic factor (BDNF). We analyzed the markers according to disease group, state, severity, and prognosis. We enrolled 60 patients with recent ON (15 AQP4-ON; 14 MOG-ON; 31 DSN-ON). At baseline, AQP4-ON group had significantly higher serum GFAP levels than did other groups. In AQP4-ON group, serum GFAP levels were significantly higher in the attack state than in the remission state and correlated with poor visual acuity. As a prognostic indicator, serum BDNF levels were positively correlated with follow-up visual function in the AQP4-ON group (r = 0.726,p = 0.027). Serum GFAP reflected disease status and severity, while serum BDNF was identified as a prognostic biomarker in AQP4-ON. Serum biomarkers are potentially helpful for patients with ON, particularly those with AQP4-ON.
Research of deformation law about guide rails under the action of mining deformation in mine vertical shaft
Authors: Zhao Jianlong , Ma Chi , Han Jinna , Xiao Xingming , Jiang Yuqiang 
Published: April 2023

AbstractTo lay a foundation for alleviating the influence of mining shaft deformation (MSD) on the guide rail (GR) and monitoring the shaft deformation state, this paper studies the deformation law and mechanism of the guide rail under the MSD. Firstly, a spring is used to simplify the interaction between the shaft lining and surrounding rock soil mass (SRSM) under MSD, and its stiffness coefficient is deduced by the elastic subgrade reaction method. Secondly, a simplified finite element model is established based on spring element, the stiffness coefficient is calculated by the derivation formula, and its effectiveness is verified. Finally, the deformation law and mechanism of GR are analyzed under different types and degrees of MSD, and the deformation characteristics are studied under the disconnection between the shaft, bunton and guide rail. The results show that the established finite element model can better simulate the interaction between the shaft lining and SRSM, and the calculation efficiency is greatly improved. The guide rail deformation (GRD) has a strong ability to characterize MSD and owns the distinctive feature corresponding to different types and degrees of MSD and the connection state. This research can provide reference and guidance for the shaft deformation monitoring and the maintenance and installation of the GR, and also lays a groundwork for studying operation characteristic of hoisting conveyance under MSD.
Prediction of air quality index based on the SSA-BiLSTM-LightGBM model
Authors: Zhang Xiaowen , Jiang Xuchu , Li Ying 
Published: April 2023

AbstractThe air quality index (AQI), as an indicator to describe the degree of air pollution and its impact on health, plays an important role in improving the quality of the atmospheric environment. Accurate prediction of the AQI can effectively serve people’s lives, reduce pollution control costs and improve the quality of the environment. In this paper, we constructed a combined prediction model based on real hourly AQI data in Beijing. First, we used singular spectrum analysis (SSA) to decompose the AQI data into different sequences, such as trend, oscillation component and noise. Then, bidirectional long short-term memory (BiLSTM) was introduced to predict the decomposed AQI data, and a light gradient boosting machine (LightGBM) was used to integrate the predicted results. The experimental results show that the prediction effect of SSA-BiLSTM-LightGBM for the AQI data set is good on the test set. The root mean squared error (RMSE) reaches 0.6897, the mean absolute error (MAE) reaches 0.4718, the symmetric mean absolute percentage error (SMAPE) reaches 1.2712%, and the adjusted R2 reaches 0.9995.
Quantifying the role of antecedent Southwestern Indian Ocean capacitance on the summer monsoon rainfall variability over homogeneous regions of India
Authors: Thandlam Venugopal , Rahaman Hasibur , Rutgersson Anna , Sahlee Erik , Ravichandran M. , Ramakrishna S. S. V. S. 
Published: April 2023

AbstractThe role of ocean variability is at a focal point in improving the weather and climate forecasts at different spatial and temporal scales. We study the effect of antecedent southwestern Indian Ocean mean sea level anomaly (MSLA) and sea surface temperature anomalies (SSTA) as a proxy to upper ocean heat capacitance on all India summer monsoon rainfall (AISMR) during 1993–2019. SSTA and MSLA over the southwestern Indian Ocean (SWIO) have been influenced by El Niño-Southern Oscillation (ENSO), the impact of ENSO-induced SWIO variability was low on rainfall variability over several homogeneous regions. Rainfall over northeast (NE) and North India (EI) has been modulated by ENSO-induced SSTA and MSLA over SWIO, thus effecting the total AISMR magnitude. The ENSO-induced changes in heat capacitance (SSTA and MSLA) over SWIO during antecedent months has less impact on west coast of India, central India and North India (NI) rainfall variability. The long-term trend in pre-monsoonal SSTA and MSLA over SWIO shows decreasing rainfall trend over NI, NE, and EI in the recent time. Furthermore, the cooler (warmer) anomaly over the western Indian Ocean affects rainfall variability adversely (favourably) due to the reversal of the wind pattern during the pre-monsoon period. While SSTA and MSLA are increasing in the SWIO, large-scale variability of these parameters during preceding winter and pre-monsoon months combined with surface winds could impact the inter-annual AISMR variability over homogeneous regions of India. Similarly, from an oceanic perspective, the antecedent heat capacitance over SWIO on an inter-annual time scale has been the key to the extreme monsoon rainfall variability.
Embracing Theory as Liberatory Practice: Journeying Toward a Critical Praxis of Speech, Language, and Hearing
Authors: Privette Chelsea 
Published: April 2023

Purpose:
The purpose of this tutorial is to guide practitioners to a critical praxis of speech, language, and hearing. This tutorial provides a foundational knowledge of critical theory as an approach to framing, conceptualizing, and interpreting phenomena and demonstrates its application to the speech, language, and hearing profession.

Method:
This tutorial reviews critical theory as a category of frameworks that challenge existing power structures and provides a critical analysis of the profession's approach to language using a raciolinguistic framework. Questions are included for the reader to guide self-reflection and preparation for enacting a critical praxis oriented toward justice. Recommended readings are provided for the reader to continue the journey beyond these pages.

Results:
The author presents a critical praxis of speech, language, and hearing, drawing directly from two additional critical frameworks: Black fugitivity and culturally sustaining pedagogy. This critical praxis is discussed within the context of three major areas—activism, assessment, and intervention—with a reconsideration of how to leverage skills, resources, and strategies in a way that centers (racial) identity formation and multimodal communication.

Conclusion:
Next steps are suggested, and readers are invited to become theorists who continue to develop a critical praxis for their context.

Supplemental Material:

https://doi.org/10.23641/asha.22312213