bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Soft-Tissue Hematomas With Real-Time, Contrast-Enhanced Ultrasound
Authors: Kummer Tobias , Mohn Kelli J. , Bardwell Abigail J. , Boyum James H. 
Published: February 2023

Abstract
In this study, we investigated the feasibility of using contrast-enhanced ultrasound (CEUS) to detect active hemorrhage in patients presenting with soft-tissue hematomas. Adult patients with clinically suspected, actively bleeding hematomas were prospectively enrolled. Contrast-enhanced ultrasound was used to assess for contrast extravasation. Ultrasound results were compared with those of multidetector computed tomographic (MDCT) imaging, operative findings, and clinical course. Sixteen patients (9 women, 7 men; mean age, 69 [SD, 13] years) were enrolled. Thirteen patients underwent MDCT imaging during their initial visit, and for 11, CEUS and computed tomography (CT) findings were concordant. The remaining patients had a negative CEUS study that was consistent with their clinical course. In 8 patients, CT imaging showed active extravasation (6 arterial, 1 indeterminate, 1 slow venous). Contrast-enhanced ultrasound and CT findings were concordant for all cases of arterial bleeding. For 1 patient, CEUS provided superior diagnostic information by identifying a pseudoaneurysm. The 2 discrepant patient cases had a ≥3-hour delay between CT and CEUS, and in 1 patient, CEUS was limited by body habitus. The second patient had no active bleeding identified in the operating room. Compared with CT, CEUS had a sensitivity and specificity of 75% and 100%, respectively, and positive and negative predictive values were 100% and 71%, respectively. Diagnostic accuracy was 85% in this limited study. Contrast-enhanced ultrasound is a promising alternative to MDCT in select patients and may sometimes provide superior clinical information. Limiting factors are large hematoma size, unfavorable anatomic location, and body habitus.
The Role of Reconstruction on Desmoid Tumor Recurrence
Authors: Meade Anna , Wisecarver Ian , Cho Min-Jeong , Davis Justin J. , Duque Sofia , Farewell Jordyn T. , Zhang Andrew Y. 
Published: February 2023

Background
Desmoid tumors occur throughout the body, presenting as aggressive, locally invasive lesions that can impede quality of life. Many controversies remain regarding the optimal surgical treatment of desmoid. This article presents a systematic review and meta-analysis on surgical management, focusing on risk of recurrence and the utility of reconstruction within this unique patient population.

Methods
A systematic review was conducted to search for articles. The clinical course of patients diagnosed with desmoid tumors and treated by our institution's multidisciplinary team was retrospectively reviewed over a 13-year period. Meta-analysis study findings were compared with our cohort.

Results
From the systematic review, 10 studies with level of evidence III were found, which resulted in 981 patients. Twenty patients from our institution met the inclusion criteria for our study. In both our study cohort and the pooled results, recurrence was significantly higher in patients with positive microscopic margin after resection. In our study cohort, patients with recurrence had higher rates of positive margins compared with those without recurrence (83.3% vs 7.1%, P = 0.004), whereas the pooled study showed a difference of margin positivity of 50% vs 40% (P = 0.01). No patients who underwent reconstruction in our study cohort had a recurrence during the study period.

Conclusion
In both our cohort and pooled results, recurrence was significantly higher in patients with positive margins after initial resection. Reconstruction was not found to be a risk factor for recurrence. Reconstruction following desmoid tumor resection should be considered a viable option if a large and aggressive resection is required to obtain negative margins.
The Rule of 10s for Cleft Repair: A Historical Review of the Literature
Authors: Schalet Grant , Langlie Jake , Kim Minji , Thaller Seth 
Published: February 2023

Background:
Cleft lip is a ubiquitous maxillofacial birth defect encountered globally. Repair of this anomaly has been well established in the literature. Historically, studies have recommended initiating surgical repair by the “Rule of 10s.” This states that a baby should be at least 10 weeks of age or older, achieve a weight of 10 pounds, have a hemoglobin exceeding 10 g/dL, and have a white blood cell count <10,000/mm3 before undergoing surgery. However, with advances in both pediatric anesthesia and surgical technique, the concept of prioritizing earlier surgery requires a closer examination of this widespread concept.

Objective:
The aim of this study was to assess the validity of the Rule of 10s for cleft lip repair and to determine whether plastic surgeons should continue to follow this as a strict rule or employ it as a guideline.

Methods:
A literature search was conducted by G.S., and reviewed by J.L. and M.K. All studies that addressed the “Rule of 10s” for cleft lip patients were considered. Articles were chosen from a comprehensive set of databases, including EMBASE, MEDLINE, and Cochrane Central Register of Controlled Trials databases in March 2022. A literature search was conducted using the following keywords: rule of 10s, Millard criteria, cleft lip/palate, cleft lip/palate repair, and cleft lip/palate complications. Reference lists of selected studies were reviewed for other appropriate publications. Meta-analyses, prospective, randomized clinical trials, retrospective reviews, letters, and literature reviews were included. Single case reports, non-English publications, animal studies, and comments were excluded.

Results:
Among the studies included in this review, the authors found that the Rule of 10s has undergone a limited evaluation within the context of today’s advances in surgical technique and anesthesia. The current articles generally conclude surgeons may proceed with earlier cleft repair on otherwise healthy infants who do not meet all criteria of the Rule of 10s.

Conclusions:
When taking into consideration the current advances in surgical technique and diminished risks of anesthesia, the Rule of 10s should be applied only as a guideline instead of a rule in plastic surgery. Surgeons should address each patient individually and adhere more rigidly to the Rule of 10s when the infant does not have characteristics warranting expedited repair.
Radiomics and Artificial Intelligence Study of Masseter Muscle Segmentation in Patients With Hemifacial Microsomia
Authors: Han Wenqing , Xia Wenjin , Zhang Ziwei , Kim Byeong Seop , Chen Xiaojun , Yan Yingjie , Sun Mengzhe , Lin Li , Xu Haisong , Chai Gang , Wang Lisheng 
Published: February 2023

Background:
Hemifacial microsomia (HFM) is one of the most common congenital craniofacial condition often accompanied by masseter muscle involvement. U-Net neural convolution network for masseter segmentation is expected to achieve an efficient evaluation of masseter muscle.

Methods:
A database was established with 108 patients with HFM from June 2012 to June 2019 in our center. Demographic data, OMENS classification, and 1-mm layer thick 3-dimensional computed tomography were included. Two radiologists manually segmented masseter muscles in a consensus reading as the ground truth. A test set of 20 cases was duplicated into 2 groups: an experimental group with the intelligent algorithm and a control group with manual segmentation. The U-net follows the design of 3D RoI-Aware U-Net with overlapping window strategy and references to our previous study of masseter segmentation in a healthy population system. Sorensen dice-similarity coefficient (DSC) muscle volume, average surface distance, recall, and time were used to validate compared with the ground truth.

Results:
The mean DSC value of 0.794±0.028 for the experiment group was compared with the manual segmentation (0.885±0.118) with α=0.05 and a noninferiority margin of 15%. In addition, higher DSC was reported in patients with milder mandible deformity (r=0.824, P<0.05). Moreover, intelligent automatic segmentation takes only 6.4 seconds showing great efficiency.

Conclusions:
We first proposed a U-net neural convolutional network and achieved automatic segmentation of masseter muscles in patients with HFM. It is a great attempt at intelligent diagnosis and evaluation of craniofacial diseases.
The Rise of Facial Palsy on Social Media Over the Last 5 Years
Authors: Knoedler Leonard , Knoedler Samuel , Chartier Christian , Panayi Adriana C. , Orgill Dennis P. , Moog Philipp , Oezdemir Berkin , von Isenburg Sarah , Studier-Fischer Alexander , Prantl Lukas , Kehrer Andreas 
Published: February 2023

Background:
Social media (SoMe) has become a powerful platform for distributing health information. Facial palsy (FP) results in functional and social impairment and lowers quality of life. Social media may help to raise awareness of FP sequalae. This study aims to determine the FP information growth on SoMe platforms and parameters that influence user engagement on FP content.

Methods:
Five commonly used SoMe platforms (Facebook, Instagram, TikTok, Twitter, and Reddit) were analyzed. Data on 18 FP hashtags and their social interaction parameters (posts, likes, reaches, comments, shares, language, and country of origin) over the past 5 years (July 31, 2016, to July 31, 2021) were collected. In-depth account analysis was performed on the 5 most popular Instagram profiles associated with FP.

Results:
The annual growth curve was positive on each platform. Facial Palsy Awareness Week 2021 trended best on TikTok. Facebook accumulated 315,411 likes and 1,922,678 reaches on 8356 posts. On Instagram, 24,968 posts gathered 4,904,124 likes and 9,215,852 reaches. TikTok users interacted on 3565 posts, accumulating 4,304,155 likes and 4,200,368 reaches. The implementation of reels (P<0.001) and the profile host interacting with their followers by liking (P<0.001) and replying (P<0.001) to users’ comments significantly increased the engagement rate.

Conclusions:
Facial palsy is of increasing interest on SoMe. Facial palsy surgeons may post reels, interact with their community, and engage into FPAW to promote user engagement.
Surgical Anatomy for Asian facial Contouring: A Personal Perspective
Authors: Hwang Kun 
Published: February 2023

This paper introduces my personal perspective on anatomic structures for reduction malarplasty, mandibular contouring surgery, and masseter muscle resection. The zygomaticofacial nerve innervates a rectangular area, and each side measures 18.8±4 and 15.8±3.4 mm. The center of the rectangle is located laterally, at 17.3±5.5 mm from the lateral canthus, and then inferiorly, at 18.1±3.1 mm. The point of the zygomaticotemporal nerve appears at the margin of the zygomatic bone, 11.29±2.65 mm below the zygomaticofrontal suture and 21.76±2.76 mm from the superior border of the zygomatic arch. The inferior alveolar nerve in the mandibular canal runs above the lower one-third of the mandibular body. The terminal mandibular canal is located at an average of 4.5 mm under the mental foramen, advances 5.0 mm anteriorly, loops, and ends at the foramen. The facial nerve trunk is located 11 to 14 mm medial to the posterior border of the mandible. The trunk emerges out of the stylomastoid foramen and runs anteroinferiorly at an angle of 45°. The deep branch of the middle masseteric artery travels deep in the muscle, close to the periosteum of the mandible in 94% of cases. The average diameter is 1.23±0.26 mm. The masseteric nerve runs anteriorly and inferiorly between the deep and the middle layers of the masseter. It is observed at 33±5.6 mm from the inferior border of the muscle on the anterior third vertical line of the masseter muscle and at 47±5.5 mm in the posterior third.
Quality of Life and Symptoms Before and After Nasal Septoplasty With or Without Turbinoplasty Compared With Control Individuals in Saudi Arabia
Authors: Alanazy Sultan , AlQuniabut Ibrahim , Alenezi Mazyad M. , Almutairi Homood , Almutairi Abdulrahman , Altheyab Fatemah , Al-Wutayd Osama 
Published: February 2023

Objectives:
Nasal septal deviation is a common health issue that can significantly impact the quality of life. Although nasal septoplasty is commonly performed in Otolaryngology practice, its effectiveness has been questioned. This was the first study to assess disease-specific quality of life in patients undergoing nasal septoplasty with or without turbinoplasty in Saudi Arabia.

Methods:
This was a prospective observational study of patients undergoing nasal septoplasty with or without turbinoplasty for nasal obstruction due to septal deviation with or without inferior turbinate hypertrophy. Nasal Obstruction Symptom Evaluation (NOSE) scores were collected preoperatively and 3 months postoperatively and were compared with controls.

Results:
This study involved 200 subjects, including 40 patients in the case group and 160 individuals in the control group. The mean preoperative and 3-month postoperative NOSE scores of the case group were (58.4±23.7 and 15.0±18.6, P<0.001), respectively. However, the postoperatively NOSE score did not reach NOSE score in control group (13.28±8.13, P=0.377). All nasal symptoms statistically and clinically improved postoperatively. There were no significant differences in NOSE score changes among cases preoperatively and postoperatively according to age, sex, or the presence of allergic rhinitis or asthma.

Conclusions:
Nasal septoplasty with or without turbinoplasty leads to improvements in disease-specific quality of life as assessed by NOSE scores and significantly improved nasal symptoms 3 months after surgery.
Anterior Dental Implant in Grafted Cleft Alveolus: A Clinical Comparison Between Intramembranous and Endochondral Bone Graft
Authors: Sodnom-Ish Buyanbileg , Eo Mi Young , Park Min Woo , Lee Ju Young , Seo Mi Hyun , Yang Hoon Joo , Kim Soung Min 
Published: February 2023

Background:
Alveolar bone graft is usually performed during the early mixed dentition phase, at the chronological age of 6 to 8 years old, to reconstruct the cleft alveolus. As the appropriate time for implant placement is after completion of full growth, it can result in a likelihood of resorption. The aim of this study is to compare the clinical outcomes of anterior dental implants with delayed bone grafting using iliac crest (endochondral) and mandibular ramus or symphysis (intramembranous) bone in adolescents to adulthood patients with cleft alveolus.

Materials and Methods:
This study included 10 patients with cleft alveolus who underwent delayed bone grafting with autogenous block bone and particulate cancellous bone and marrow (PCBM) from the mandibular ramus and symphysis with dental implant placement, and iliac crest. The success of the treatment was evaluated through clinical and radiographic examination including marginal bone loss measurement of the implants.

Results:
All patients underwent delayed bone grafting between the ages of 11 and 21.1 years (mean age: 15.1±4.3 y). The implant diameters ranged from 3.8 to 4.5 mm and the lengths ranged from 8.0 to 11.5 mm. All of the implants were integrated successfully and survived during the 3-year follow-up period.

Conclusions:
Delayed bone grafting followed by implant placement showed long-term stability with satisfactory esthetic and functional rehabilitation. One of the main advantages of delayed bone grafting is to achieve adequate bone support for future dental implant placements with less bone resorption compared with those of primary, early secondary, and secondary bone grafting.
Evaluation of the Effects of Dual Antiplatelet Therapy on Guided Bone Regeneration in Peri-Implant Bone Defect
Authors: Kobat Mehmet Ali , Dundar Serkan , Bozoglan Alihan , Gelen Mehmet Ali , Artas Gokhan , Kirtay Mustafa , Tasdemir İsmail , Karasu Mehdi , Habek Osman 
Published: February 2023

In this study, the authors aim to investigate the effect of dual antiplatelet agents on peri-implant–guided bone regeneraation by studying a sample of rats with titanium implants in their tibias. The rats were randomly divided into 5 groups: acetylsalicylic acid (ASA) (n=10), treated with 20 mg/kg of ASA; ASA+CLPD (Clopidogrel): (n=10), treated with 20 mg/kg of ASA and 30 mg/kg of clopidogrel; ASA+PRSG (Prasugrel): (n=10), treated with 20 mg/kg of ASA and 15 mg/kg of prasugrel; ASA+TCGR (Ticagrelor): (n=10), treated with 20 mg/kg of ASA and 300 mg/kg of ticagrelor; and a control group (n=10) received no further treatment after implant surgery. Bone defects created half of the implant length circumferencial after implant insertion and defects filled with bone grafts. After 8 weeks experimental period, the rats sacrified and implants with surrounding bone tissues were collected to histologic analysis; bone filling ratios of defects (%) and blood samples collected to biochemical analysis (urea, creatinine, aspartate aminotransferase, alanine aminotransferase, phosphorus, magnesium, alkaline phosphatase, calcium, and parathormone). A statistically significant difference was not detected between the groups for all parameters (P>0.05). When the percentage of new bone formation was examined, it was found that there was no statistically significant difference between the groups (P>0.05). Antiplatelet therapy may not adversely affect guided bone regeneration in peri-implant bone defects.
Prediction of Enophthalmos in Medial Orbital Wall Fracture: Suggested Coordinate Plane for Making Surgical Decisions
Authors: Mo Young Woong , Ryu Da Hye , Shin Hea Kyeong , Lee Won Jai 
Published: February 2023

Background:
Enophthalmos is one of the most distressing complications of blowout orbital fractures. Although several studies have been conducted on the topic of indications of early surgical correction, none have been performed using a set of measurable parameters.

Methods:
The study quantitatively examined orbital fracture areas (OFA) and volumes (OFV) retrospectively of 242 patients with isolated medial orbital wall fractures that were treated conservatively during a 12-year period (from 2009 to 2021). Three plastic surgeons measured enophthalmos >6 months after trauma. The correlations between parameters and enophthalmos in the study cohort were analyzed. In addition, patients treated operatively, and nonoperatively were compared with assess the suitability of the predictive model.

Results:
Significant correlations were observed between several parameters and late enophthalmos. Total 2.59 cm2 of OFA (ie, OFA >2.59 cm2) or 1.45 cm3 of OFV (ie, OFV >1.45 cm3) corresponds to 2 mm of enophthalmos. Multiple regression analysis revealed the following coefficients: −0.208 is a constant (P<0.001), with 0.695 and 0.372 for OFA and OFV, respectively (P<0.001 for both OFA and OFV).

Conclusions:
The study shows that enophthalmos can be more accurately predicted when OFA and OFV are simultaneously considered in patients with isolated medial wall fractures. Finally, an algorithm and a “blowout fracture coordinate plane” was proposed to aid treatment decision-making in isolated medial wall fractures.
Artificial Intelligence Splint in Orthognathic Surgery for Skeletal Class III Malocclusion: Design and Application
Authors: Liu Zhikai , Xu Chunwei , Zhu Zhaokun , Tai Yue , Liu Yao , Luo En 
Published: February 2023

Background:
Digital splints are indispensable in orthognathic surgery. However, the present design process of splints is time-consuming and has low reproducibility. To solve these problems, an algorithm for artificial intelligent splints has been developed in this study, making the automatic design of splints accessible.

Methods:
Firstly, the algorithm and program of the artificial intelligence splint were created. Then a total of 54 patients with skeletal class III malocclusion were included in this study from 2018 to 2020. Pre and postoperative radiographic examinations were performed. The cephalometric measurements were recorded and the difference between virtual simulation and postoperative images was measured. The time cost and differences between artificial intelligent splints and digital splints were analyzed through both model surgery and radiographic images.

Results:
The results showed that the efficiency of designing splints is significantly improved. And the mean difference between artificial intelligent splints and digital splints was <0.15 mm in model surgery. Meanwhile, there was no significant difference between the artificial intelligent splints and digital splints in radiological image analysis.

Conclusions:
In conclusion, compared with digital splints, artificial intelligent splints could save time for preoperative design while ensuring accuracy. The authors believed that it is conducive to the presurgical design of orthognathic surgery.
Natural Antibodies Are Associated With Rejection and Long-term Renal Allograft Loss in a Multicenter International Cohort
Authors: See Sarah B. , Yang Xue , Burger Carole , Lamarthée Baptiste , Snanoudj Renaud , Shihab Ronzon , Tsapepas Demetra S. , Roy Poulomi , Larivière-Beaudoin Stéphanie , Hamelin Katia , Mendoza Rojas Aleixandra , van Besouw Nicole M. , Bartosic Amanda , Daniel Nikita , Rodica Vasilescu E. , Mohan Sumit , Cohen David , Ratner Lloyd , Baan Carla C. , Bromberg Jonathan S. , Cardinal Héloïse , Anglicheau Dany , Sun Yifei , Zorn Emmanuel 
Published: February 2023

Background.
Potentially harmful nonhuman leukocyte antigen antibodies have been identified in renal transplantation, including natural immunoglobulin G antibodies (Nabs) reactive to varied antigenic structures, including apoptotic cells.

Methods.
In this retrospective, multicenter study, we assessed Nabs by reactivity to apoptotic cells in sera collected from 980 kidney transplant recipients across 4 centers to determine their association with graft outcomes.

Results.
Elevated pretransplant Nabs were associated with graft loss (hazard ratio [HR] 2.71; 95% confidence interval [CI], 1.15-6.39; P  =  0.0232), the composite endpoint of graft loss or severe graft dysfunction (HR 2.40; 95% CI, 1.13-5.10; P = 0.0232), and T cell–mediated rejection (odds ratio [OR] 1.77; 95% CI, 1.07-3.02; P = 0.0310). High pretransplant Nabs together with donor-specific antibodies (DSAs) were associated with increased risk of composite outcomes (HR 6.31; 95% CI, 1.81-22.0; P = 0.0039). In patients with high pretransplant Nabs, the subsequent development of posttransplant Nabs was associated with both T cell–mediated rejection (OR 3.64; 95% CI, 1.61-8.36; P = 0.0021) and mixed rejection (OR 3.10; 95% CI, 1.02-9.75; P = 0.0473). Finally, elevated pre- and posttransplant Nabs combined with DSAs were associated with increased risk of composite outcomes (HR 3.97; 95% CI, 1.51-10.43; P = 0.0052) and T cell–mediated rejection (OR 7.28; 95% CI, 2.16-25.96; P = 0.0016).

Conclusions.
The presence of pre- and posttransplant Nabs, together with DSAs, was associated with increased risk of poor graft outcomes and rejection after renal transplantation.