bluuebunny/crossref_metadata_2025_split huggingface dataset:
Closed‐Loop Multi‐Objective Optimization for Cu–Sb–S Photo‐Electrocatalytic Materials’ Discovery
Authors: Bai Yang , Khoo Zi Hui Jonathan , I Made Riko , Xie Huiqing , Lim Carina Yi Jing , Handoko Albertus Denny , Chellappan Vijila , Cheng Jianwei Jayce , Wei Fengxia , Lim Yee‐Fun , Hippalgaonkar Kedar 
Published: September 2023

AbstractCopper antimony sulfides are regarded as promising catalysts for photo‐electrochemical water splitting because of their earth abundance and broad light absorption. The unique photoactivity of copper antimony sulfides is dependent on their various crystalline structures and atomic compositions. Here, a closed‐loop workflow is built, which explores Cu–Sb–S compositional space to optimize its photo‐electrocatalytic hydrogen evolution from water, by integrating a high‐throughput robotic platform, characterization techniques, and machine learning (ML) optimization workflow. The multi‐objective optimization model discovers optimum experimental conditions after only nine cycles of integrated experiments–machine learning loop. Photocurrent testing at 0 V versus reversible hydrogen electrode (RHE) confirms the expected correlation between the materials’ properties and photocurrent. An optimum photocurrent of −186 µA cm−2 is observed on Cu–Sb–S in the ratio of 9:45:46 in the form of single‐layer coating on F‐doped SnO2 (FTO) glass with a corresponding bandgap of 1.85 eV and 63.2% Cu1+/Cu species content. The targeted intelligent search reveals a nonobvious CuSbS composition that exhibits 2.3 times greater activity than baseline results from random sampling.
Revealing Co‐N4@Co‐NP Bridge‐Enabled Fast Charge Transfer and Active Intracellular Methanogenesis in Bio‐Electrochemical CO2‐Conversion with Methanosarcina Barkeri
Authors: Xia Rongxin , Cheng Jun , Chen Zhuo , Zhang Ze , Zhou Xinyi , Zhou Junhu , Zhang Meng 
Published: September 2023

AbstractTo significantly advance the bio‐electrochemical CO2‐conversion rate and unfold the correlation between the abiotic electrode and the attached microorganisms, an atomic‐nanoparticle bridge of Co‐N4@Co‐NP crafted in metal–organic frameworks‐derived nanosheets is integrated with a model methanogen of Methanosarcina barkeri (M. barkeri). The direct bonding of N in Co‐N4 and Fe in member protein of Cytochrome b (Cytb) activates a fast direct electron transfer path while the Co nanoparticles further strengthen this bonding via decreasing the energy gap between the p‐band center of N and the d‐band center of Fe. This multiorbital tuning operation of Co nanoparticles also enhances the coenzyme F420‐mediated electron transfer by enabling the electron flow direct to the hydrogenation sites. Particularly, the increased surface electric field of the Co‐N4@Co‐NP bridge‐based nanosheet electrode facilitates the interfacial Na+ accumulation to expedite ATPase transport for powering intracellular CO2 conversion. Remarkably, the self‐assembled M.barkeri‐Co‐N4@Co‐NP biohybrid achieves a high methane production rate of 3860 mmol m−2 day−1, which greatly outperforms other reported biohybrid systems. This work demonstrates a comprehensive scrutinization of biotic–abiotic energy transfer, which may serve as a guiding principle for efficient bio‐electrochemical system design.
Enhancing the Carrier Transport in Monolayer MoS2 through Interlayer Coupling with 2D Covalent Organic Frameworks
Authors: Wang Can , Cusin Luca , Ma Chun , Unsal Elif , Wang Hanlin , Consolaro Valentina Girelli , Montes‐García Verónica , Han Bin , Vitale Stefania , Dianat Arezoo , Croy Alexander , Zhang Haiming , Gutierrez Rafael , Cuniberti Gianaurelio , Liu Zhaoyang , Chi Lifeng , Ciesielski Artur , Samorì Paolo 
Published: September 2023

AbstractThe coupling of different 2D materials (2DMs) to form van der Waals heterostructures (vdWHs) is a powerful strategy for adjusting the electronic properties of 2D semiconductors, for applications in opto‐electronics and quantum computing. 2D molybdenum disulfide (MoS2) represents an archetypical semiconducting, monolayer thick versatile platform for the generation of hybrid vdWH with tunable charge transport characteristics through its interfacing with molecules and assemblies thereof. However, the physisorption of (macro)molecules on 2D MoS2 yields hybrids possessing a limited thermal stability, thereby jeopardizing their technological applications. Herein, the rational design and optimized synthesis of 2D covalent organic frameworks (2D‐COFs) for the generation of MoS2/2D‐COF vdWHs exhibiting strong interlayer coupling effects are reported. The high crystallinity of the 2D‐COF films makes it possible to engineer an ultrastable periodic doping effect on MoS2, boosting devices’ field‐effect mobility at room temperature. Such a performance increase can be attributed to the synergistic effect of the efficient interfacial electron transfer process and the pronounced suppression of MoS2’s lattice vibration. This proof‐of‐concept work validates an unprecedented approach for the efficient modulation of the electronic properties of 2D transition metal dichalcogenides toward high‐performance (opto)electronics for CMOS digital circuits.
Augmenting Immunotherapy via Bioinspired MOF‐Based ROS Homeostasis Disruptor with Nanozyme‐Cascade Reaction
Authors: Wang Ruifang , Qiu Maosong , Zhang Lei , Sui Meiju , Xiao Long , Yu Qiao , Ye Chaohui , Chen Shizhen , Zhou Xin 
Published: September 2023

AbstractDespite its remarkable clinical breakthroughs, immune checkpoint blockade (ICB) therapy remains limited by the insufficient immune response in the “cold” tumor. Nanozyme‐based antitumor catalysis is associated with precise immune activation in the tumor microenvironment (TME). In this study, a cascade‐augmented nanoimmunomodulator (CMZM) with multienzyme‐like activities, which includes superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and glutathione oxidase (GSHOx), that dissociates under an acidic and abundant GSH TME, is proposed for multimodal imaging‐guided chemodynamic therapy (CDT)/photodynamic therapy (PDT) enhanced immunotherapy. Vigorous multienzyme‐like activities can not only produce O2 to alleviate hypoxia and promote the polarization of M2 to M1 macrophages, but also generate ROS (•OH and 1O2) and deplete GSH in the TME to expose necrotic cell fragments and reverse immunosuppressive TME by eliciting the maturation of dendritic cells and infiltration of cytotoxic T lymphocytes (CTLs) in tumors. Therefore, inhibitory effects on both primary and distant tumors are achieved through synergy with an α‐PD‐L1 blocking antibody. This cascade multienzyme‐based nanoplatform provides a smart strategy for highly efficient ICB immunotherapy against “cold” tumors by revising immunosuppressive TME.
Purposive Design of Stretchable Composite Electrodes for Strain‐Negative, Strain‐Neutral, and Strain‐Positive Ionic Sensors
Authors: Choi Hyeongseok , Jeong Unyong 
Published: September 2023

AbstractSoft ionic sensors have emerged as a promising device form to accommodate various future electronic applications. One of the hurdles in ionic sensors is that the sensing signals by mechanical deformation and other stimuli are mixed up. Although the performance of the ionic sensors is highly dependent on the structure of electrodes, systematic investigation of purposive electrode design has been rarely explored. This study proposes a simple strategy for designing stretchable composite electrodes which make the ionic sensor strain‐negative, strain‐neutral, and strain‐positive. This study reveals that such strain‐responses can be obtained by adjusting the surface coverage of the electrically‐effective conductive fillers. On the basis of the concept, deposition of a Au film on an elastomer composite and crack formation of the Au film are presented for the practical fabrication of a highly reproducible strain‐neutral ionic sensor. A completely strain‐independent temperature sensor is demonstrated by using the Au crack‐based ionic sensor. In addition, this study demonstrates a two‐terminal shear sensor capable of recognizing shear directions by combining the strain‐positive and strain‐negative electrodes.
Picking pithy plants: Pith selectivity by wild white‐faced capuchin monkeys, Cebus imitator
Authors: DePasquale Allegra N. , Poirier Alice C. , Mah Megan A. , Villalobos Suarez Cinthia , Guadamuz Adrian , Cheves Hernandez Saul , Lopez Navarro Ronald , Hogan Jeremy D. , Rothman Jessica M. , Nevo Omer , Melin Amanda D. 
Published: September 2023

AbstractUnderstanding diet selectivity is a longstanding goal in primate ecology. Deciphering when and why primates consume different resources can provide insights into their nutritional ecology as well as adaptations to food scarcity. Plant pith, the spongy interior of plant stems, is occasionally eaten by primates, but the context is poorly understood. We examine the ecological, mechanical, chemical, and nutritional basis of plant pith selection by a wild, frugivorous‐omnivorous primate (Cebus imitator). We test the hypothesis that pith is a fallback food, that is, consumed when fruit is less abundant, and test for differences between plant species from which pith is eaten versus avoided. We collected 3.5 years of capuchin pith consumption data to document dietary species and analyzed “pith patch visits” in relation to fruit availability, visits to fruit patches, and climatic seasonality. We analyzed dietary and non‐dietary species for relative pith quantity, mechanical hardness, odor composition, and macronutrient concentrations. Capuchins ate pith from 11 of ~300 plant species common in the dry forest, most commonly Bursera simaruba. We find that pith consumption is not directly related to fruit availability or fruit foraging but occurs most frequently (84% of patch visits) during the months of seasonal transition. Relative to common non‐dietary species, dietary pith species have relatively higher pith quantity, have softer outer branches and pith, and contain more terpenoids, a class of bioactive compounds notable for their widespread medicinal properties. Our results suggest that greater pith quantity, lower hardness, and a more complex, terpenoid‐rich odor profile contribute to species selectivity; further, as pith is likely to be consistently available throughout the year, the seasonality of pith foraging may point to zoopharmacognosy, as seasonal transitions typically introduce new parasites or pathogens. Our study furthers our understanding of how climatic seasonality impacts primate behavior and sheds new light on food choice by an omnivorous primate.
Examining postmounting grooming in male golden snub‐nosed monkeys to investigate the functions of same‐sex mounts
Authors: Huang Pengzhen , Fang Gu , Teichroeb Julie A. , Zhang Endi , Chen Min 
Published: September 2023

AbstractSame‐sex mounting behavior has been documented across primate species and several biological functions, that are often difficult to differentiate, have been proposed. Postmounting affiliative behaviors (e.g., embracing and grooming) have been partly overlooked and their performance may more clearly reveal the function of same‐sex mounts for different age‐sex classes. Here, considering postmounting grooming behaviors (PMG), we tested the affiliation hypothesis for same‐sex mounts in an all‐male unit (AMU) of captive golden snub‐nosed monkeys (Rhinopithecus roxellana) (n = 7−8) and the needing to learn hypothesis in the juveniles of the AMU (n = 4) and the juvenile male from the neighboring one‐male unit in Shanghai Wild Animal Park, China from November 2014 to June 2015. A total of 1986 same‐sex mounts were recorded from the AMU individuals and the juvenile of the neighboring one‐male unit. We found that neither dyadic proximity‐based association nor grooming‐based affiliation predicted the occurrence of mounts in the AMU, and PMG was more likely to occur in nontense than tense social contexts, providing no support for the affiliation hypothesis. Although dyadic grooming‐based affiliation predicted the occurrence of PMG, it exerted no influence on the occurrence of mounts, which was necessary to support the hypothesis. However, consistent with the needing to learn hypothesis, from ages two to four, juveniles' mounting duration increased and they performed pelvic thrusting during mounting more and more often as they grew older. Reciprocated series mounts were much more common among juveniles than other mounting dyads, providing learning opportunities for both participants. The mounter was more likely to groom the mountee at the end of a mount among juveniles than other mounting dyads, suggesting that juvenile mounters may profit from mounting and groom mountees in return for providing them with opportunities to learn copulatory skills. A hypothesis that merits further investigation.
Amyloid and tau‐PET in early‐onset AD: Baseline data from the Longitudinal Early‐onset Alzheimer's Disease Study (LEADS)
Authors: Cho Hanna , Mundada Nidhi S. , Apostolova Liana G. , Carrillo Maria C. , Shankar Ranjani , Amuiri Alinda N. , Zeltzer Ehud , Windon Charles C. , Soleimani‐Meigooni David N. , Tanner Jeremy A. , Heath Courtney Lawhn , Lesman‐Segev Orit H. , Aisen Paul , Eloyan Ani , Lee Hye Sun , Hammers Dustin B. , Kirby Kala , Dage Jeffrey L. , Fagan Anne , Foroud Tatiana , Grinberg Lea T. , Jack Clifford R. , Kramer Joel , Kukull Walter A. , Murray Melissa E. , Nudelman Kelly , Toga Arthur , Vemuri Prashanthi , Atri Alireza , Day Gregory S. , Duara Ranjan , Graff‐Radford Neill R. , Honig Lawrence S. , Jones David T. , Masdeu Joseph , Mendez Mario , Musiek Erik , Onyike Chiadi U. , Riddle Meghan , Rogalski Emily J. , Salloway Stephen , Sha Sharon , Turner Raymond Scott , Wingo Thomas S. , Wolk David A. , Koeppe Robert , Iaccarino Leonardo , Dickerson Bradford C. , La Joie Renaud , Rabinovici Gil D. ,   LEADS Consortium
Published: September 2023

AbstractINTRODUCTIONWe aimed to describe baseline amyloid‐beta (Aβ) and tau‐positron emission tomograrphy (PET) from Longitudinal Early‐onset Alzheimer's Disease Study (LEADS), a prospective multi‐site observational study of sporadic early‐onset Alzheimer's disease (EOAD).METHODSWe analyzed baseline [18F]Florbetaben (Aβ) and [18F]Flortaucipir (tau)‐PET from cognitively impaired participants with a clinical diagnosis of mild cognitive impairment (MCI) or AD dementia aged < 65 years. Florbetaben scans were used to distinguish cognitively impaired participants with EOAD (Aβ+) from EOnonAD (Aβ−) based on the combination of visual read by expert reader and image quantification.RESULTS243/321 (75.7%) of participants were assigned to the EOAD group based on amyloid‐PET; 231 (95.1%) of them were tau‐PET positive (A+T+). Tau‐PET signal was elevated across cortical regions with a parietal‐predominant pattern, and higher burden was observed in younger and female EOAD participants.DISCUSSIONLEADS data emphasizes the importance of biomarkers to enhance diagnostic accuracy in EOAD. The advanced tau‐PET binding at baseline might have implications for therapeutic strategies in patients with EOAD.HIGHLIGHTS
72% of patients with clinical EOAD were positive on both amyloid‐ and tau‐PET.
Amyloid‐positive patients with EOAD had high tau‐PET signal across cortical regions.
In EOAD, tau‐PET mediated the relationship between amyloid‐PET and MMSE.
Among EOAD patients, younger onset and female sex were associated with higher tau‐PET.
Low‐dose sevoflurane co‐administered with propofol‐based general anaesthesia obliterates intra‐operative neurophysiological monitoring in an infant
Authors: Nakahari H. , Wilton N. C. T. , Ikeda M. , Kojima T. 
Published: September 2023

SummaryThe influence of general anaesthetic agents on intra‐operative neurophysiological monitoring in neonates and infants has rarely been reported. Propofol‐based anaesthesia is recommended to avoid suppression of neurophysiological monitoring. However, the administration of propofol in children undergoing prolonged procedures, especially those younger than six months, should be carefully controlled due to the potential risk of propofol infusion syndrome. Adding a small dose of inhalational anaesthetic can be an option to reduce propofol requirements. Recent guidelines in Japan suggest limiting inhalational anaesthetics to less than 0.5 minimum alveolar concentrations when co‐administered with low‐dose propofol during intra‐operative neuromonitoring. However, there is still insufficient evidence regarding the impact of sevoflurane on neurophysiological monitoring when co‐administered with propofol in infants. This report describes a case of a three‐month‐old infant undergoing spinal lipoma resection in which there was a dramatic suppression of neurophysiological monitoring with the addition of 0.35–0.45% sevoflurane to propofol‐based anaesthesia.
Formal Deoxygenative Cross‐Coupling of Aldehydes to Ketones through α‐Haloboronates: A Route to Deoxygenative Hydroacylation of Aldehydes†
Authors: Hu Zihao , Zhang Wanqi , Tao XU 
Published: September 2023

Comprehensive SummaryAldehydes are a kind of important synthons and reagents in organic synthesis. The efforts on transformations of aldehydes are highly rewarding and have always attracted considerable attention. Herein, a cross‐coupling of aldehydes with α‐haloboronates has been achieved under dual nickel/photoredox catalysis system. Considering the α‐haloboronates can be easily obtained from aldehydes with our deoxygenative difunctionalization of carbonyls (DODC) strategy, this protocol provides a formal deoxygenative cross‐coupling of aldehydes to one‐carbon‐prolonged ketone products. The mild conditions enabled good functional group tolerance and broad substrate applicability. The application of this method was presented via a tunable synthesis of two ketones with very similar skeletons from two same aldehydes.
Rhodium‐Catalyzed Asymmetric Transfer Hydrogenation of Heterocyclic Diaryl Ketones: Facile Access to Key Intermediate of Baloxavir†
Authors: Wang Li , Xiao Renwei , Song Jingyuan , Zheng Long‐Sheng , Lang Qiwei , Chen Gen‐Qiang , Zhang Xumu 
Published: September 2023

Comprehensive SummaryTransition metal‐catalyzed asymmetric transfer hydrogenation has been proven to be a powerful approach for the synthesis of chiral alcohols. Herein, a highly efficient and enantioselective transfer hydrogenation of dibenzoheptaheterocyclic ketones catalyzed by an arene‐tethered TsDPEN‐based Rh(III) catalyst has been successfully developed, and a variety of dibenzoheptaheterocyclic ketones were reduced by a 1/1 mixture of formic acid and DBU (1,8‐diazabicyclo[5.4.0]undec‐7‐ene) with high yields and enantioselectivities. With this method, the asymmetric reduction of 7,8‐difluorodibenzo[b,e]thiepin‐11(6H)‐one has been realized, providing the key intermediate of baloxavir marboxil with >99% yield and >99% ee at a substrate/catalyst molar ratio of 1000.
Corn response to long‐term seasonal weather stressors: A review
Authors: Ortez Osler A. , Lindsey Alexander J. , Thomison Peter R. , Coulter Jeffrey A. , Singh Maninder Pal , Carrijo Daniela R. , Quinn Daniel J. , Licht Mark A. , Bastos Leonardo 
Published: September 2023

AbstractLong‐term weather patterns (environmental conditions or stresses exceeding 10 days in length) have the potential to influence corn (Zea mays L.) growth, development, and yield. This review summarizes the current knowledge (with emphasis placed on the Midwestern U.S. production environment) on how long‐term weather conditions affect corn growth and yield, including (i) drought and heat stress, (ii) solar radiation, and (iii) distribution of heat unit accumulation during the season. Each section contains summaries of how these environmental factors influence corn growth and yield and provides context into past events experienced. The focus of the review is on dent corn grown for grain production, though relevant issues related to other types (i.e., silage corn) are included. This review also discusses agronomic recommendations or considerations to help alleviate the negative effects of stress conditions and identify areas where future research would be beneficial to continue improving the resiliency of corn cropping systems. Periods of high heat and water deficit as well as limited light availability challenge the ability to maximize yield production in corn. Temperature affects crop growth and development through the season, and accurately describing phenological progression using heat unit accumulation is a challenge. Advances in corn breeding and genetics, hybrid selection, and agronomic management practices will be key to ensuring long‐range productivity and fully leveraging possible benefits from the shifts in long‐range weather patterns.
The use of videos for diabetes patient education: A systematic review
Authors: Hoe Cosette Yoon Wey , Ahmad Badariah , Watterson Jessica 
Published: September 2023

AbstractDiabetes prevalence is rising worldwide, calling for public health concerns and interventions to improve prevention and management. Self‐care is an important component in reducing the incidence of complications from diabetes, but it must be taught. This systematic review aims to synthesise the evidence for education videos for people with diabetes. Electronic databases, including Ovid (Medline, Embase, EmCare), PsychInfo, CINAHL, Web of Science and Scopus, were searched for studies on educational videos for patients with diabetes that met the inclusion criteria. A total of 36 studies met the inclusion criteria. Data extracted were synthesised through narrative synthesis. Studies examined outcomes including biological (i.e., glycated haemoglobin (HbA1C), weight, BMI), non‐biological (health literacy, self‐efficacy) and subjective feedback (i.e., acceptability, cultural appropriateness). The most common length of video was ≤10 min. Online dissemination was the most common method of video distribution. A statistically significant decrease (ranging from −0.1% to −2.1%) in HbA1C was noted in 7 of 12 studies examining this outcome. Other studies also found evidence of improvement in health literacy, self‐efficacy, physical activity, medication adherence and other outcomes. Feedback from participants was generally positive, and emphasis was placed on the need for cultural appropriateness and representation in the educational videos.
CD8+ T cells reduce neuroretina inflammation in mouse by regulating autoreactive Th1 and Th17 cells through IFN‐γ
Authors: Wu Sihan , Zhang Xuan , Hu Cuiping , Zhong Yajie , Chen Jun , Chong Wai Po 
Published: September 2023

AbstractVarious regulatory CD8+ T‐cell subsets have been proposed for immune tolerance and have been implicated in controlling autoimmune diseases. However, their phenotypic identities and suppression mechanisms are not yet understood. This study found that coculture of T‐cell receptor (TCR)‐ or interferon (IFN)‐β‐activated CD8+ T cells significantly suppressed the cytokine production of Th1 and Th17 cells. By experimenting with the experimental autoimmune uveitis (EAU), we found that adoptive transfer of TCR or IFN‐β‐activated CD8+ T cells significantly lessened disease development in an IFN‐γ‐dependent manner with a decreased uveitogenic Th1 and Th17 response. Interestingly, after adoptive transfer into the EAU mice, the IFN‐γ+CD8+ T cells were recruited more efficiently into the secondary lymphoid organs during the disease‐priming phase. This recruitment depends on the IFN‐γ‐inducible chemokine receptor CXCR3; knocking out CXCR3 abolishes the protective effect of CD8+ T cells in EAU. In conclusion, we identified the critical role of IFN‐γ for CD8+ T cells to inhibit Th1 and Th17 responses and ameliorate EAU. CXCR3 is necessary to recruit IFN‐γ+CD8+ T cells to the secondary lymphoid organ for the regulation of autoreactive Th1 and Th17 cells.