bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic bases of language control in bilinguals: Evidence from an EEG study
Authors: Liu Dongxue , Xing Zehui , Huang Junjun , Schwieter John W. , Liu Huanhuan 
Published: April 2023

AbstractPrevious studies have debated whether the ability for bilinguals to mentally control their languages is a consequence of their experiences switching between languages or whether it is a specific, yet highly‐adaptive, cognitive ability. The current study investigates how variations in the language‐related gene FOXP2 and executive function‐related genes COMT, BDNF, and Kibra/WWC1 affect bilingual language control during two phases of speech production, namely the language schema phase (i.e., the selection of one language or another) and lexical response phase (i.e., utterance of the target). Chinese–English bilinguals (N = 119) participated in a picture‐naming task involving cued language switches. Statistical analyses showed that both genes significantly influenced language control on neural coding and behavioral performance. Specifically, FOXP2 rs1456031 showed a wide‐ranging effect on language control, including RTs, F(2, 113) = 4.00, FDR p = .036, and neural coding across three‐time phases (N2a: F(2, 113) = 4.96, FDR p = .014; N2b: F(2, 113) = 4.30, FDR p = .028, LPC: F(2, 113) = 2.82, FDR p = .060), while the COMT rs4818 (ts >2.69, FDR ps < .05), BDNF rs6265 (Fs >5.31, FDR ps < .05), and Kibra/WWC1 rs17070145 (ts > −3.29, FDR ps < .05) polymorphisms influenced two‐time phases (N2a and N2b). Time‐resolved correlation analyses revealed that the relationship between neural coding and cognitive performance is modulated by genetic variations in all four genes. In all, these findings suggest that bilingual language control is shaped by an individual's experience switching between languages and their inherent genome.
Interactions between sex and the age at disease onset on cardiometabolic risk factors in a Ghanaian population with type 2 diabetes mellitus: A cross‐sectional study
Authors: Akilla Martin Awe , Banyeh Moses , Awinibuno Ignatius Abowini Nchor 
Published: April 2023

AbstractBackground and AimThe are sex differences in cardiometabolic risk factors in type 2 diabetes mellitus (T2DM) as well as the age at disease onset. However, the impact of these risk factors on the age at onset of T2DM is less known in the Ghanaian population. An understanding of the differential impact of cardiometabolic risk factors on the age at onset on T2DM may lead to sex‐specific interventions in preventive and management strategies for T2DM.MethodsThe study was cross‐sectional from January to June 2019 at the Bolgatanga regional hospital. The study involved 163 T2DM patients (Female = 103, Male = 60), aged from 25 to 70 years. The body mass index (BMI) and the waist‐to‐hip ratio (WHR) were measured following standardized anthropometric techniques. Fasting venous blood samples were collected and analyzed for cardiometabolic risk factors including total cholesterol (TCHOL) and low‐density lipoprotein (LDL) cholesterol.ResultsWhile TCHOL was higher in males than females (mean [SD]: F = .78 [1.37], M = 4.27 [1.39]) and LDL higher in females than males (mean [SD]: [F = 4.33 [1.22], M = 3.87 [1.26]), these did not, however, attain conventional statistical significance for TCHOL (t = 1.985, p = 0.05) and LDL (t = 2.001, p = 0.05). There were however, significant interactions between sex and the age at disease onset on TCHOL (t = −2.816, p = 0.006) and LDL (t = −2.874, p = 0.005), which were independent of the BMI, WHR and disease duration. The relationship between the age at disease onset and that of TCHOL and LDL were positive in females but negative in males.ConclusionFasting plasma TCHOL and LDL increases with increasing age at onset of T2DM in females but decreases in males. Strategies for the prevention and management of T2DM should be sex‐specific. Females with T2DM should be given more attention regarding their fasting plasma cholesterol (total) and LDL cholesterol as they are more likely than men to have increased levels of these lipids with increasing age at disease onset.
Green technology for water scarcity: An entrepreneurial business may bring transformation in water management practices
Authors: Siddique Muhammad , Sanjrani Manzoor A. , Rani Keenjhar 
Published: April 2023

AbstractDespite the contributions of modern business practices to environmentally sustainable transformation, there is not enough information on different types of green technologies and their applications. Therefore, it is essential to identify and classify business models that focus on the management practices of green technology. While the literature on green technology business models has received increasing attention over the last decade, interdisciplinary research into this growing phenomenon is still in its infancy and fragmented. The study focuses on the need for green technology for water management worldwide. Such management practices for green technology represent a research gap in the study area because no one has worked in this field before. There should be research to address people's management practices of green entrepreneurial business. The literature highlights that the issue of water crises may be minimized with the management practices of green entrepreneurial business and by applying global green water treatment techniques. The authors believe that this study would be very beneficial for future research on policymaking based on management practices of green technology that promote environmental sustainability through a green business environment.
Efficacy and Safety of Direct Oral Anticoagulants in Patients With Atrial Fibrillation Combined With Hypertension: A Multicenter, Retrospective Cohort Study
Authors: Guan Chengfu , Xu Wenlin , Lv Meina , Wu Tingting , Chen Xia , Zhang Wang , Huang Nianxu , Dai Hengfen , Gu Ping , Huang Xiaohong , Du Xiaoming , Li Ruijuan , Zheng Qiaowei , Lin Xiangsheng , Liu Yuxin , Zhang Min , Liu Xiumei , Zhu Zhu , Zhang Jinhua 
Published: April 2023

AbstractWhether there are differences in direct oral anticoagulants efficacy and safety in patients with atrial fibrillation (AF) combined with hypertension is unclear. We therefore conducted a multicenter retrospective cohort study to assess the differences in the efficacy and safety of direct oral anticoagulants in patients with AF combined with hypertension. This multicenter retrospective cohort study was based on data from 15 centers in China and included 2086 patients with AF. We divided the patients into dabigatran and rivaroxaban groups according to their direct oral anticoagulants. Propensity score matching was used to balance the covariates between the groups. Due to our limited sample size, the number of cases of some clinical events with low incidence was small. During a mean follow‐up period of 10 months, a total of 268 (12.9%) bleeding events occurred, including 27 (1.3%) major bleeding events and 241 (11.6%) minor bleeding events, and 45 (2.2%) thromboembolic events. In patients with AF combined with hypertension, rivaroxaban was associated with a higher major bleeding incidence than dabigatran (odds ratio [OR], 2.89 [95% confidence interval [CI, 1.22‐6.87]; P = .012). In contrast, the risk of thromboembolism and minor bleeding was similar for rivaroxaban (OR, 0.55 [95%CI, 0.29‐1.01]; P = .069) and dabigatran (OR, 0.82 [95%CI, 0.63‐1.08]; P = .150). Based on the results of this study, in patients with AF and hypertension treated with direct oral anticoagulants, the incidence of thromboembolism and minor bleeding was not statistically different between dabigatran and rivaroxaban, but compared with rivaroxaban, dabigatran was associated with a lower risk of major bleeding.
Bioethanol as a potential eco‐friendlier feedstock for catalytic production of fuels and petrochemicals
Authors: Anekwe Ifeanyi Michael Smarte , Isa Yusuf Makarfi , Oboirien Bilainu 
Published: April 2023

AbstractBioethanol, synthesized through the valorization of biomass resources, is of great importance to many industries. As bioethanol has become more abundant and its price has decreased, it has become an attractive candidate for application as a base material for the synthesis of a variety of petrochemicals and fuel through catalysis. In this article, a comprehensive review of the catalytic conversion of bioethanol into hydrocarbons, including olefins and gasoline, is presented. In addition, developments and potential research opportunities in the field of bioethanol catalysis are provided to enhance bioethanol conversion. According to the findings of the study, despite significant progress in bioethanol conversion, further research is needed to address several challenges that will enable improved biofuel and chemical production. © 2023 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
What is the impact of veterans affairs rotations in oral and maxillofacial surgery residency?
Authors: Hershberger Matthew W. , Sierra‐Vasquez Daniel , Ford Brian , Panchal Neeraj 
Published: April 2023

AbstractPurposeOral and maxillofacial surgery (OMS) residencies commonly affiliate with Veterans Affairs Medical Centers (VAMC) to extend care for veterans. This study quantifies the surgical experience of residents at the Corporal Michael J. Crescenz (CMC) VAMC in Philadelphia, Pennsylvania and determines the number of programs affiliated with VA Medical Centers, to enumerate the educational benefits and improve veteran healthcare.MethodsThe dental project manager logs from 2012 through 2021 of the CMC VAMC operating room were analyzed, and cases were categorized into 12 groups. The implant cases from 2012 through 2021 were quantified. Program affiliations were determined using a VA Office of Academic Affiliation report.ResultsThere were 1359 procedures (760 cases) performed. Dentoalveolar (n = 967) was the most common category, and extractions (n = 384) were the most common procedure. The least cases and procedures were performed in 2012 (n = 14; n = 23). The most cases were performed in 2019 (n = 137), and the most procedures were performed in 2019 and 2021 (n = 255). There were 3133 implants placed. There are 40 OMS programs affiliated with VA Medical Centers; more dual degree (n = 24) than single degree (n = 16) programs having an affiliation.ConclusionThe CMC VAMC offers robust dentoalveolar experience and is increasing in surgical volume, representing the expected needs of an aging veteran population. An increasing budget and millions of eligible veterans indicates VA medical centers nationally will continue to provide valuable surgical experiences.
Downregulation of MUS81 expression inhibits cell migration and maintains EBV latent infection through miR‐BART9‐5p in EBV‐associated gastric cancer
Authors: Zhang Yan , Shi Duo , Zhang Xing , Wu Shuo , Liu Wen , Luo Bing 
Published: April 2023

AbstractEpstein–Barr virus (EBV) infection is associated with the occurrence and development of gastric cancer (GC). Methyl methanesulfonate and ultraviolet‐sensitive gene 81 (MUS81) is the catalytic component of a structure‐specific endonuclease and plays an important role in chromosomal stability. However, the link between EBV infection and MUS81 remains unclear. In the present study, we found that MUS81 expression was much lower in EBV‐associated GC cells than in EBV‐negative GC. MUS81 acts as an oncogene in GC by inducing the cell migration and proliferation. Western blot and luciferase reporter assays revealed that miR‐BART9‐5p directly targeted MUS81 and downregulated its expression. Additionally, overexpression of MUS81 in EBV‐positive GC cells inhibited the expression of EBV nuclear antigen 1 (EBNA1). EBNA1 is critical for the pathogenesis of EBV‐associated tumors and the maintenance of a stable copy number of the viral genomes. Altogether, these results indicated that the lowering MUS81 expression might be a mechanism by EBV to maintain its latent infection.
Retracted: Combined effects of inflammation and coronavirus disease 2019 (COVID‐19) on the risks of anxiety and depression: A cross‐sectional study based on UK Biobank
Authors: Zhang Na , Qi Xin , Chang Hong , Li Chun'e , Qin Xiaoyue , Wei Wenming , Cai Qingqing , He Dan , Zhao Yijing , Shi Sirong , Chu Xiaoge , Wen Yan , Jia Yumeng , Zhang Feng 
Published: April 2023

AbstractInfection‐induced perturbation of immune homeostasis could promote psychopathology. Psychiatric sequelae have been observed after previous coronavirus outbreaks. However, limited studies were conducted to explore the potential interaction effects of inflammation and coronavirus disease 2019 (COVID‐19) on the risks of anxiety and depression. In this study, first, polygenic risk scores (PRS) were calculated for eight COVID‐19 clinical phenotypes using individual‐level genotype data from the UK Biobank. Then, linear regression models were developed to assess the effects of COVID‐19 PRS, C‐reactive protein (CRP), systemic immune inflammation index (SII), and their interaction effects on the Generalized Anxiety Disorder‐7 (GAD‐7, 104 783 individuals) score and the Patient Health Questionnaire‐9 (PHQ‐9, 104 346 individuals) score. Several suggestive interactions between inflammation factors and COVID‐19 clinical phenotypes were detected for PHQ‐9 score, such as CRP/SII × Hospitalized/Not_Hospitalized in women group and CRP × Hospitalized/Unscreened in age >65 years group. For GAD‐7 score, we also found several suggestive interactions, such as CRP × Positive/Unscreened in the age ≤65 years group. Our results suggest that not only COVID‐19 and inflammation have important effects on anxiety and depression but also the interactions of COVID‐19 and inflammation have serious risks for anxiety and depression.
Breaking rules yet helpful for all: Beneficial effects of pro‐customer rule breaking on employee outcomes
Authors: Kim Su Kyung (Irene) , Zhan Yujie 
Published: April 2023

SummaryPro‐customer rule breaking refers to employees' breaking of organizational rules with the primary intention of helping customers or providing better customer service. In spite of its prosocial nature, it is unclear whether and how pro‐customer rule breaking also benefits employees who engage in this behavior. Drawing on self‐determination theory, we examine employees' well‐being and voice at work as outcomes of pro‐customer rule breaking. Across a simulation study and a critical incident‐based survey study, we found that pro‐customer rule breaking was positively related to employee psychological need fulfillment, which, in turn, was associated with lower emotional exhaustion, higher job satisfaction, and increased voice. Furthermore, normative conflict with organizational rule moderated the positive relationship between pro‐customer rule breaking and psychological need fulfillment such that employees with high normative conflict with organizational rule (i.e., employee perception that their existing organizational rule results in inefficiency and that their organization could be much better if it changed its practices) benefited more from their pro‐customer rule breaking. We discuss the theoretical and practical implications of these findings and offer directions for future research.
Melatonin‐induced myeloblastosis viral oncogene homologs alleviate fresh‐cut lotus root browning during storage by attenuating flavonoid biosynthesis and reactive oxygen species
Authors: Zhang Chen , Xin Ying , Wang Zhiwen , Qin Lili , Cao Longyun , Li Haifeng , Ma Xintian , Yin Jingyu , Zhao Zixue , Liu Pinjie , Tang Jiawei , Dong Chen 
Published: April 2023

AbstractBACKGROUNDLotus roots (Nelumbo nucifera Gaertn.) are rich in nutrients and have ornamental and food value. However, browning has caused huge economic losses and security risks during the storage and harvesting of fresh‐cut lotus. This study investigated the role of melatonin in inhibiting lotus browning, and illustrates its molecular mechanism.RESULTSThe application of melatonin effectively retarded the process of lotus browning, enhanced reactive oxygen species (ROS) scavenging enzyme activity, and inhibited the activity of polyphenol oxidase (PPO), and peroxidase (POD). Melatonin reduced flavonoid content, and decreased enzymatic activity in flavonoid biosynthesis. Transcriptome Sequencing (RNA‐seq) was used to screen the genes regulated by exogenous melatonin when defending against fresh‐cut lotus browning. Gene co‐expression analysis (GCN) indicated that the transcription factors MYB5, MYB6, and MYB308, activated by melatonin, were negatively related to the expression of PPO and the genes related to flavonoid and phenylpropanoid biosynthesis. These myeloblastosis viral oncogene homologs (MYBs) were positively related to the expression of genes encoding the enzymes in glutathione metabolism.CONCLUSIONMelatonin retarded lotus browning by transcriptional suppression of key genes associated with flavonoid and phenylpropanoid biosynthesis through the stimulation of MYB5, MYB6, and MYB308. © 2023 Society of Chemical Industry.
Rapid analysis of titer, aggregate, and intact mass of antibody therapeutics using automated multi‐dimensional liquid chromatography coupled with native mass spectroscopy
Authors: Savane Tushar Sharad , Kumar Sunil , Rathore Anurag S. 
Published: April 2023

Monoclonal antibodies are tetrameric complex proteins, primarily produced using mammalian cell culture. Attributes such as titer, aggregates, and intact mass analysis are monitored during process development/optimization. In the present study, a novel workflow such that the Protein‐A affinity chromatography is performed in the first dimension for purification and titer estimation, whereas size exclusion chromatography is employed in the second dimension to characterize size variants using native mass spectrometry. The present workflow offers a significant advantage over the traditionally used standalone Protein‐A affinity chromatography followed by size exclusion chromatography analysis in that it can monitor these four attributes in 8 min while requiring a minimal sample size (10–15 μg) and not requiring any manual peak collection. In contrast, the traditional standalone approach requires manual collection of eluted peaks in Protein‐A affinity chromatography followed by buffer exchange to a mass‐compatible buffer, which can take up to 2–3 h with considerable risk of sample loss, degradation, and induced modifications. As the biopharma industry moves to make analytical testing efficient, we believe that the approach proposed here would be of significant interest due to its ability to monitor multiple process and product quality attributes in a single workflow and via rapid analysis.
Comparison of bacterial carbon production estimates from dilution and 3H‐leucine methods across a strong gradient in ocean productivity
Authors: Landry Michael R. , Rivera Sara R. , Stukel Michael R. , Selph Karen E. 
Published: April 2023

AbstractThe uptake of 3H‐labeled leucine into proteins, a widely used method for estimating bacterial carbon production (BCP), is suggested to underestimate or overestimate bacterial growth in the open ocean by a factor of 40 uncertainty. Meanwhile, an alternative BCP approach, by the dilution method, has untested concerns about potential overestimation of bacterial growth from dissolved substrates released by filtration. We compared BCPDil and BCPLeu estimates from three cruises across a broad trophic gradient, from offshore oligotrophy to coastal upwelling, in the California Current Ecosystem. Our initial analyses based on midday microscopical estimates of bacterial size and a priori assumptions of conversions relationships revealed a mean two‐fold difference in BCP estimates (BCPDil higher), but no systematic bias between low and high productivity stations. BCPDil and BCPLeu both demonstrated strong relationships with bacteria cell abundance. Reanalysis of results, involving a different cell carbon‐biovolume relationship and informed by forward angle light scatter from flow cytometry as a relative cell size index, demonstrated that BCPDil and BCPLeu are fully compatible, with a 1 : 1 fit for bacteria of 5 fg C cell−1. Based on these results and considering different strengths of the methods, the combined use of 3H‐labeled leucine and dilution techniques provide strong mutually supportive constraints on bacterial biomass and production.
Treatment of burn hypertrophic scar with fractional ablative laser‐assisted drug delivery can decrease levels of hyperpigmentation
Authors: Kurup Sanjana , Travis Taryn E. , Shafy Rahma Abd El , Shupp Jeffrey W. , Carney Bonnie C. 
Published: April 2023

AbstractBackgroundLaser treatments have been used to treat a variety of scar symptoms, including the appearance of scars following burn injury. One such symptom is hyperpigmentation. There are several qualitative and quantitative measures of assessing improvement in hyperpigmentation over time. The Patient and Observer Scar Assessment Scale (POSAS) and Vancouver Scar Scale (VSS) are two scales that describe characteristics of scar such as pigmentation level. These scales are limited by their qualitative nature. On the other hand, spectrophotometers provide quantitative measures of pigmentation. Prior studies have reported that laser can change scar pigmentation, but no quantitative values have been reported. The current study examines changes in scar melanin index after CO2 fractional ablative laser scar revision (FLSR) via noninvasive probe measurement in patients of various Fitzpatrick skin types (FST).Materials and MethodsPatients with scars of various sizes and etiologies were treated with FLSR. A database was constructed including 189 patients undergoing laser treatment. From this pool, individuals were selected based on the criteria that they completed at least two laser sessions and had Melanin index measurements for both of these sessions and the pre‐operative visit. This criteria resulted in 63 patients of various FST in the cohort. Melanin index, POSAS‐Observer (O) and ‐Patient (P) pigmentation and color scores and VSS‐pigmentation scores were examined over time. Demographic information (age of patient at time of first treatment, age of scar at time of first treatment, use of laser‐assisted drug delivery (LADD), gender, FST, and Ethnicity) were collected from the medical record. Patients were grouped as “responder” if their Melanin index indicated decreased levels of hyperpigmentation after FLSR treatment in more than half of their total number of visits and “nonresponder” if it did not.ResultsThe majority of patients were responders (41/63). In responder patients, measurements of Melanin index showed significantly improved levels of hyperpigmentation in hypertrophic scars after two FLSR sessions (p < 0.05). Age of patient, gender, FST, age of scar, ethnicity, or type of drug delivered by LADD did not predict responder grouping. POSAS‐O and ‐P pigmentation/color scores showed improved scores after two FLSR sessions within the responder group. POSAS‐P color scores showed improved scores after two and three FLSR sessions in the nonresponder group. VSS pigmentation scores showed improved scores after three FLSR sessions in the responder group only.ConclusionBased on Melanin index values, FLSR leads to improvements in hyperpigmentation in certain patients.