bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative risk of acute kidney injury among cancer patients treated with immune checkpoint inhibitors
Authors: Liu Fei , Wang Zixian , Li Xiaofan , Zhang Zhen , Yang Yue , Chen Junquan , Chen Dinghua , Wu Lingling , Liu Xiangyu , Han Sujun , Wang Fangming , Wahafu Wasilijiang , Gao Yibo , Ren Shancheng , Xing Nianzeng , Cai Guangyan , Chen Xiangmei 
Published: December 2022

AbstractWith the development and introduction of immune checkpoint inhibitors (ICIs) in cancer patients, immune‐related side effects have increasingly attracted attention. However, the risks of immune‐related renal toxicity are poorly characterized. In this study, we performed a network meta‐analysis (NMA) of ICI‐related randomized clinical trials (RCTs) to elucidate the comparative risk of acute kidney injury (AKI) in cancer patients receiving different ICIs. We also sought to identify other factors potentially affecting the risk of AKI. PubMed and EMBASE were searched for peer‐reviewed trial reports published between January 2000 and May 2021. Eligible studies were RCTs studying ICIs in cancer patients and reporting AKI data. We performed a frequentist NMA to evaluate the risk ratios for grade 1‐5 and grade 3‐5 AKI between the treatment groups. We also assessed the absolute incidence of AKI in the ICI‐containing arm using traditional direct meta‐analysis. Once significant heterogeneity was detected in a traditional direct meta‐analysis, multivariable meta‐regression analysis was applied to identify factors that significantly affected the absolute incidence of AKI. A total of 85 RCTs were included in this study. In the NMA for the risk of grade 1‐5 and 3‐5 AKI, ipilimumab showed a significantly higher risk than avelumab and durvalumab, whereas 1 mg/kg nivolumab plus 3 mg/kg ipilimumab (N1I3) showed a significantly higher risk than other groups. In terms of treatment ranking, durvalumab ± low‐dose tremelimumab and avelumab were consistently among the top three safest treatments for grade 1‐5 or 3‐5 AKI, whereas N1I3, ipilimumab and tremelimumab were consistently among the top three treatments with the highest risk for grade 1‐5 or 3‐5 AKI. Compared with other cancers, renal cell carcinoma and urothelial carcinoma showed a significantly higher risk of AKI. The incidence of AKI was significantly higher with ICI+chemotherapy than with ICI monotherapy. In this NMA involving large‐scale up‐to‐date ICI trials, we demonstrated the comparative safety of existing ICI drugs for grade 1‐5 and grade 3‐5 AKI. Based on data from the ICI arms of these trials, we also revealed several potential risk factors for immune‐related AKI, including tumor type and treatment paradigm.
Impact of implantation technique on conduction disturbances for TAVR with the self‐expanding portico/navitor valve
Authors: Wang Xi , Wong Ivan , Bajoras Vilhelmas , Vanhaverbeke Maarten , Nuyens Philippe , Bieliauskas Gintautas , Jørgensen Troels Højsgaard , Chen Mao , De Backer Ole , Sondergaard Lars 
Published: December 2022

AbstractBackgroundUse of a right−left (R−L) cusp overlap view for transcatheter aortic valve replacement (TAVR) with self‐expanding valves has recently been proposed aiming to reduce permanent pacemaker implantation (PPMI). An objective, data‐driven explanation for this observation is missing.AimsTo assess the impact of different implantation techniques on the risk of PPMI following TAVR with the Portico/NavitorTM transcatheter heart valve (THV; Abbott).MethodsA TAVR‐population treated with Portico/NavitorTM had the THV implanted in a right versus left anterior oblique (RAO/LAO) fluoroscopic view with no parallax in the delivery system. The impact of these different implantation views on the spatial relationship between THV and native aortic annulus and the risk of conduction disturbances and PPMI after TAVR was studied.ResultsA total of 366 matched TAVR patients were studied: 183 in the RAO group and 183 in the LAO group. The degree of aortic annulus plane tilt was significantly smaller in the RAO versus LAO group (median: 0° vs. 23°, p < 0.001), with no plane tilt in 105 out of 183 cases (57.3%) in the RAO group. At 30 days after TAVR, the overall PPMI and guideline‐directed PPMI rates were 12.6% versus 18.0% (p = 0.15) and 8.2% versus 15.3% (p = 0.04) in the RAO versus LAO group, respectively.ConclusionsUse of a R−L cusp overlap (RAO‐caudal) view for implantation of the Portico/NavitorTM valve results in less tilt of the native aortic annulus plane and a clear trend toward a lower 30‐day PPMI rate as compared to TAVR using the conventional LAO implantation view.
Exploring when, why, and how students circumscribe and compromise science careers
Authors: Jones Lee Kenneth , Hite Rebecca I. 
Published: December 2022

AbstractScience interest is decreasing in the United States, and Americans of all ages have growing mistrust toward science and scientists, potentially sourcing these negative perceptions from their youth and today's popular culture. Understanding the nature of how K‐12 students perceive scientists and science careers is vital to understanding how their perceptions of science and scientists turn toward negative or harmful stereotypes of scientists and science, causing them to eschew science and science careers. This study used the circumscription and compromise (C&C) theory of career development to discernwhen(grade level),why(gender), andhow(perceptions) students eliminate (circumscribe) science careers within distinct stages of development, thus compromising on what they perceive to be an acceptable future career. Using the Draw‐a‐Scientist Test, 576 students from two private, K‐12 schools in Texas and North Carolina were sampled to model how (using prescribed C&C stages) and why (via thematic coding) this circumscription occurs.
On‐Demand Release of Secondary Amine Bases for the Activation of Catalysts and Crosslinkers
Authors: Spitzbarth Benjamin , Eelkema Rienk 
Published: December 2022

AbstractDynamic covalent (DCv) ureas have been used abundantly to design self‐healing materials. We demonstrate that apart from self‐healing materials, the species present in the equilibrium of DCv ureas can be employed as responsive organocatalysts. Easily controllable stimuli like heat or addition of water shift the equilibrium towards isocyanate and free base which can function as an in situ released reagent. We demonstrate this application of DCv ureas with two examples. Firstly, we use the liberated base to catalytically activate a latent organocatalyst for acylhydrazone formation. Secondly, this base can be employed in an equimolar manner to trigger the release of nitrile‐N‐oxides from chlorooximes, which react with acrylate‐terminated polymers to form an isoxazoline polymer gel.
AuNP‐Modulated qPCR: An Optimized System for Detecting MIR Biophotons Released in DNA Replication**
Authors: Yang Yu , Peng Daoling , Gu Zhenglong , Jiang Lei , Song Bo 
Published: December 2022

AbstractLiving systems can utilize energy with a high efficiency. Biophotons are proposed to modulate biological functions with such efficiency; however, the underlying mechanism remains unexplored, especially due to the challenge of ultraweak mid‐infrared (MIR) light detection and the theoretical perturbation from spontaneous MIR emission. Here, we proposed an optimized system to detect MIR biophotons generated in the hydrolysis of deoxynucleotide triphosphates (dNTPs, energy‐storing molecules similar to ATP). The system used a quantitative polymerase chain reaction (qPCR) that was modulated by gold nanoparticle (AuNP) concentration and thus by the inter‐AuNP distance, which depends on the concentration above. The measurements indicate that 33‐ and 84‐THz photons are released by dNTP hydrolysis, which can drive DNA replication. Our findings provide a novel chain‐reaction‐based method for detecting MIR photons in solution, and pave a way for photon‐based insights to understand the highly efficient energy utilization of biology.
Eradicating Biofilms of Carbapenem‐Resistant Enterobacteriaceae by Simultaneously Dispersing the Biomass and Killing Planktonic Bacteria with PEGylated Branched Polyethyleneimine
Authors: Heydarian Neda , Wouters Cassandra L. , Neel Andrew , Ferrell Maya , Panlilio Hannah , Haight Tristan , Gu Tingting , Rice Charles V. 
Published: December 2022

AbstractCarbapenem‐resistant Enterobacteriaceae (CRE) are emerging pathogens that cause variety of severe infections. CRE evade antibiotic treatments because these bacteria produce enzymes that degrade a wide range of antibiotics including carbapenems and β‐lactams. The formation of biofilms aggravates CRE infections, especially in a wound environment. These difficulties lead to persistent infection and non‐healing wounds. This creates the need for new compounds to overcome CRE antimicrobial resistance and disrupt biofilms. Recent studies in our lab show that 600 Da branched polyethyleneimine (BPEI) and its derivative PEG350‐BPEI can overcome antimicrobial resistance and eradicate biofilms in methicillin‐resistant S. aureus, methicillin‐resistant S. epidermidis, P. aeruginosa, and E. coli. In this study, the ability of 600 Da BPEI and PEG350‐BPEI to eradicate carbapenem‐resistant Enterobacteriaceae bacteria and their biofilms is demonstrated. We show that both BPEI and PEG350‐BPEI have anti‐biofilm efficacy against CRE strains expressing Klebsiella pneumoniae carbapenemases (KPCs) and metallo‐β‐lactamases (MBLs), such as New Delhi MBL (NDM‐1). Furthermore, our results illustrate that BPEI affects planktonic CRE bacteria by increasing bacterial length and width from the inability to proceed with normal cell division processes. These data demonstrate the multi‐functional properties of 600 Da BPEI and PEG350‐BPEI to reduce biofilm formation and mitigate virulence in carbapenem‐resistant Enterobacteriaceae.
Pathological personality traits of maladaptive daydreamers measured by the Personality Inventory for DSM‐5 in a psychiatric sample
Authors: Horváth‐Labancz Eszter , Sándor Alexandra , Balázs Katalin , Molnár Judit , Kuritárné Szabó Ildikó 
Published: December 2022

AbstractThis study aimed to estimate the frequency of maladaptive daydreaming and to explore the pathological personality traits of probable maladaptive daydreamers. Our sample consisted of 239 psychiatric patients. After screening, 42 persons were probable maladaptive, while 197 participants prove to be normal daydreamers. Two pathological domains and three facets measured by the Personality Inventory for DSM‐5 showed a moderate significant correlation with the Maladaptive Daydreaming Scale. The score of nearly every domain and facet was slightly higher among probable maladaptive daydreamers. To quantify the difference between the groups, effect sizes were calculated: Significant difference was found on the domain level in Antagonism, while on the facet level in Hostility, Grandiosity, Attention Seeking, Unusual Beliefs and Experiences, Cognitive and Perceptual Dysregulation. The group of probable maladaptive daydreamers was further examined to identify potential subgroups. Cluster analysis revealed heterogeneity in the severeness and patterns of pathological personality domains. Cluster 1 showed higher mean scores on the PID domains and on the MDS compared to Cluster 2. Clusters 1 and 2 broke further down into two subclusters: Cluster 1a and Cluster 1b differed in their mean scores on the domains of Antagonism and Detachment; the mean scores of Cluster 2a were uniformly low on each domain, while the mean values of Cluster 2b were scattered in a mixed way on the domains. Our results suggest that maladaptive daydreaming might manifest with differently pathological personality profiles in the background. This aspect might worth considering in planning treatment.
Optimization of Ammonium Sulfate Crystallization Under Ammonium Nitrate Based on Response Surface Method
Authors: Zi Gaoyong , Huang Bangfu , Dai Meng , Shi Zhe , Wen Zhenjing , Li Wanjun , Luo Liubin , Yang Linjing 
Published: December 2022

AbstractThe response surface method is used to study the influence mechanism of three factors (seed crystal concentration, pH value, and stirring rate) on ammonium sulfate crystallization (average particle size and coefficient of variation [C.V.] value) under ammonium nitrate to prove the effect of ammonium nitrate doping on ammonium sulfate crystallization. Regression equations between each response value and the influencing factors are established. Results show that the interaction between the seed crystal concentration and the stirring rate is stronger than that between the seed crystal concentration and the pH and that between the pH and the stirring rate. The error between the verified model values and the experimental values is minimized when the seed crystal concentration is 1.5%, the pH is 4.5, and the stirring rate is 250 r min−1, at which the average particle size is 1.238 mm, and the C.V. value is 73.53. After optimization, the crystal morphology changes from needle‐ and flake‐like crystals to cubes, resulting in crystals with large average particle size, uniform distribution, regular morphology, and diffraction peak intensity that is close to that in the analysis of pure ammonium sulfate.
Pancreatic cancer with pseudoaneurysm after duckbill‐shaped anti‐reflux metal stent placement: A case report
Authors: Kinoshita Keisuke , Mizukami Kazuhiro , Fukuda Kensuke , Okamoto Kazuhisa , Ogawa Ryo , Okimoto Tadayoshi , Kodama Masaaki , Murakami Kazunari 
Published: December 2022

AbstractA 74‐year‐old man was diagnosed with unresectable pancreatic cancer with obstructive jaundice. Chemotherapy with gemcitabine and nab‐paclitaxel was initiated after placement of a duckbill‐shaped anti‐reflux metal stent (D‐ARMS). A period of 1 month after D‐ARMS placement, the patient developed hematemesis and entered severe shock following emergency admission for further evaluation.Contrast‐enhanced computed tomography revealed a pseudoaneurysm in the gastroduodenal artery, coincident with the site of D‐ARMS placement, and bleeding from the same site was diagnosed. Angiography was performed, and the pseudoaneurysm was successfully treated by transcatheter arterial embolization using coils. The patient was subsequently discharged from hospital and experienced no further bleeding until his death due to an aggravation of the pancreatic cancer after 2 months. We report a case of pancreatic cancer with pseudoaneurysm after D‐ARMS placement.
Shifting climate conditions affect recruitment in Midwestern stream trout, but depend on seasonal and spatial context
Authors: Maitland Bryan M. , Latzka Alexander W. 
Published: December 2022

AbstractClimate change is a complex threat to freshwater ecosystems. Effects on aquatic species will likely differ among populations depending on seasonal and spatial context, which makes a detailed understanding of population responses to shifting climate conditions key to guiding strategic decision‐making. However, few empirical studies have tested for such context dependency on distinct populations across seasons or at large spatial scales. We used 26 years of standardized survey data on recreationally and economically important brook trout (Salvelinus fontinalis) and brown trout (Salmo trutta) in Wisconsin, USA to assess short‐ and long‐term variability in population trends, and quantify the influence of seasonal and spatial climate variability (air temperatures and precipitation) on annual recruitment strength (as indexed by young‐of‐year [YOY] relative abundance in summer). Some short‐term population fluctuations were spatially consistent across the state, indicative of broadscale environmental forcing. Over the longer term, average YOY and age 1 and older brook trout relative abundance has declined since 2006, especially for YOY, while brown trout abundance has substantially increased. The effects of climate conditions on recruitment varied by species, season, and latitude. Increasing maximum summer temperatures were associated with lower brook trout recruitment, but higher brown trout recruitment. The effect for both species was stronger at lower latitudes. Spring temperatures were positively related to brown trout recruitment at lower latitudes; in mid‐latitude and northern streams, they were related to increasing recruitment up to about 1 standard deviation, above which recruitment declined. High and low winter and spring precipitation were associated with precipitous declines in recruitment for both species. By contrast, summer precipitation was positively related to recruitment in northern streams for brook trout and southern streams for brown trout. Our results demonstrate that shifts in climate can affect recruitment in similar species differently depending on temporal (seasonal) and spatial (warm, southern regions compared with cool, northern regions) context. Given trout population trends in Wisconsin and climate projections for the Midwestern United States, location‐ and species‐specific management actions are needed that account for this context dependency. Management should aim to maximize the resiliency of populations to extreme climate conditions by buffering negative influences on recruitment.
Intensity, determinants, and impacts of liana load on tropical trees in central Africa
Authors: Loubota Panzou Grace Jopaul , Loumeto Jean‐Joel , Chantrain Arthur , Gourlet‐Fleury Sylvie , Doucet Jean‐Louis , Forni Eric , Beeckman Hans , Ilondea Bhely Angoboy , Fayolle Adeline 
Published: December 2022

AbstractLianas can create dense foliage that reduces the light available for the host trees on which they grow and can directly damage the host trees during their development. A better estimation of liana load and understanding of the determinants and impacts of liana load in tropical forests are both important in community ecology and ecosystem science. This has, however, never been studied to date in central Africa. Here, we evaluated the intensity, determinants, and impacts of liana load in three forest sites in central Africa. We determined the liana load categories for all trees belonging to 78 of the most dominant tree species (2683 trees in total), with tree diameters ranging from 10 to 250 cm. The liana load was visually estimated as the liana cover on host tree using simple scale indices, and the proportion of trees covered by lianas defined as the liana prevalence was estimated for each species. Overall, 42% of the 2683 trees were liana‐loaded and the number of liana‐loaded trees was higher for smaller diameter classes in the three forest sites. Within each forest site, there was a significant difference in liana prevalence among coexisting species. Taller trees with shallow crowns were less covered by liana at the tree level, whereas trees belonging to light‐demanding and wind‐dispersed species showed a lower liana prevalence rate at the species level. In each forest site, the liana load significantly affected tree height–diameter allometry, with liana‐loaded trees being shorter for the same diameter. Lianas promote the structural complexity and influence tree diversity and ecosystem functioning of tropical forests.
The fusion oncogene VAV1‐MYO1F triggers aberrant T‐cell receptor signaling in vivo and drives peripheral T‐cell lymphoma in mice
Authors: Morrish Emma , Wartewig Tim , Kratzert Andreas , Rosenbaum Marc , Steiger Katja , Ruland Jürgen 
Published: December 2022

AbstractVAV1‐MYO1F is a recently identified gain‐of‐function fusion protein of the proto‐oncogene Vav guanine nucleotide exchange factor 1 (VAV1) that is recurrently detected in T‐cell non‐Hodgkin's lymphoma (T‐NHL) patients. However, the pathophysiological functions of VAV1‐MYO1F in lymphomagenesis are insufficiently defined. Therefore, we generated transgenic mouse models to conditionally express VAV1‐MYO1F in T‐cells in vivo. We demonstrate that VAV1‐MYO1F triggers cell autonomous activation of T‐cell signaling with an activation of the ERK, JNK, and AKT pathways. VAV1‐MYO1F expression induces a T‐cell activation phenotype with high surface expression of CD25, ICOS, CD44, PD‐1, and decreased CD62L as well as aberrant T‐cell differentiation, proliferation, and neoplastic transformation. Consequently, the VAV1‐MYO1F expressing T‐cells induce a malignant T lymphoproliferative disease with 100% penetrance in vivo that mimics key aspects of human peripheral T‐cell lymphoma. These results demonstrate that the human T‐cell oncogene VAV1‐MYO1F is sufficient to trigger oncogenic T‐cell signaling and neoplastic transformation, and moreover, it provides a new clinically relevant mouse model to explore the pathogenesis of and treatment concepts for human T‐cell lymphoma.
Phosphine‐Functionalized Porous Materials for Catalytic Organic Synthesis
Authors: Gäumann Patrick , Cartagenova Daniele , Ranocchiari Marco 
Published: December 2022

AbstractPhosphine ligands are of unique importance in catalysis, especially as ligands for transition metals. Homogeneous catalysis is by far the broadest application of phosphines in industrial processes. The heterogenization of phosphines is challenging even though it would appeal to the chemical industry as a valid strategy for recovery and reutilization. In this Review, we discuss approaches for the immobilization of phosphines through the synthesis of phosphine‐functionalized porous polymers, such as metal‐organic frameworks (MOFs), covalent organic frameworks (COFs), and porous organic polymers (POPs). We critically discuss the synthetic strategies for preparing monomers, linkers, and porous materials. We highlight the most successful applications of phosphine‐based porous catalysts and correlate them with their properties, structure, and performance.
What is limiting the potential window in aqueous sodium‐ion batteries? Online study of the hydrogen‐, oxygen‐ and CO2‐evolution reactions at NaTi2(PO4)3 and Na0.44MnO2 electrodes
Authors: Winkler Daniel , Stüwe Teja , Werner Daniel , Griesser Christoph , Thurner Christoph , Stock David , Kunze‐Liebhäuser Julia , Portenkirchner Engelbert 
Published: December 2022

AbstractNaTi2(PO4)3 (NTP) and Na0.44MnO2 (NMO), and their derivatives, have emerged as the most promising materials for aqueous Na‐ion batteries. For both, NTP and NMO, avoiding the evolution of hydrogen and oxygen is found to be mandatory in order to mitigate material dissolution. Intriguingly, however, no direct determination of the hydrogen and oxygen evolution reactions (HER and OER) has yet been carried out. Using differential electrochemical mass spectrometry (DEMS) we directly identify the onset potentials for the HER and OER. Surprisingly, the potential window is found to be significantly smaller than suggested by commonly employed cyclic voltammetry measurements. CO2 evolution, upon decomposition of carbon black, is observed at an onset potential of 1.61 VRHE, which is 0.25 V more cathodic than the OER for the NMO electrode. Our results show that the state‐of‐the‐art carbon additive plays a crucial role in the stability of the positive NMO electrode in the ion battery.