bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of short-term cranial electrotherapy stimulation on sleep quality in athletes: A pilot study
Authors: Tan Chenhao , Wang Jinhao , Yin Jun , Cao Guohuan , Qiu Jun 
Published: September 2023

Background:
To verify the effect of a 5-day cranial electrotherapy stimulation (CES) intervention on sleep quality in professional athletes.

Methods:
25 professional athletes with poor sleep quality participated in the study. Athletes belonging to the CES group (12 athletes) received a 5-day CES intervention, and those in the control group did not receive any intervention. Objectively and subjected assessed sleep quality was measured 1 week before and after the intervention using an Actigraphy activity recorder, Pittsburgh sleep quality index (PSQI), and Insomnia Severity Index (ISI).

Results:
Objectively measured sleep efficiency increased after CES intervention (P = .013), while the difference between the pretest and posttest of the control group was not significant. For total sleep time (TST), the main effects and interaction were not significant. However, the analysis on wake after sleep onset showed wake after sleep onset decreased after CES intervention (P = .015). No significant interaction was found in subjectively assessed sleep quality but only revealed an improvement in both groups.

Conclusion:
The CES intervention of 30 minutes per day for 5 consecutive days enhanced objective sleep quality in athletes with sleep quality problems. The intervention increased sleep efficiency by lowering awake time after falling asleep.
Risk of antiangiogenic adverse events in metastatic colorectal cancer patients receiving aflibercept in combination with chemotherapy: A meta-analysis
Authors: Ge Pu , Han Chunyan , Reyila Abudurousuli , Liu Diyue , Hong Wenying , Liu Jiaxin , Zhang Jinzi , Han Xiao , Li Xialei , Huang Mengjie , Fan Siyuan , Kaierdebieke Ayidana , Wu Xiaoyu , Huang Xiaolu , Guo Weirui , Liu Siyu , Bian Ying 
Published: September 2023

Background:
Aflibercept has been approved for the treatment of metastatic colorectal cancer for more than a decade, but its antiangiogenesis adverse effect profile during treatment remains unclear. This study is conducted to systematically review the risk of antiangiogenic adverse events in patients with metastatic colorectal cancer receiving aflibercept plus chemotherapy.

Methods:
We searched databases, including PubMed, Embase and the Cochrane Library up to September 9, 2021. Relevant randomized controlled trials (RCTs) and single-arm studies were included in the review. Statistical analyses were performed using R to calculate the summary incidence rate of antiangiogenic-related adverse events, odds ratios and 95% CIs. Heterogeneity among the included studies was assessed by subgroup analysis. Publication bias analysis and sensitivity analysis were performed to confirm the reliability of the results.

Results:
A total of 2889 patients from 10 studies met the inclusion criteria. The quality of the included studies was evaluated as qualified for further quantitative synthesis. In part of single-arm studies, the occurrence rates were 44.2% (95%CI, 39.7–48.7%) for hypertension, 31.3% (95% CI, 19.3–43.3%) for proteinuria, 27.3% (95%CI, 21.2–33.4%) for epistaxis, 22.5% (95%CI, 7.8–37.3%) for hemorrhage events, 8.0% (95%CI, 2.0–14 .0%) for venous thromboembolic event in all grades and 22.6% (95%CI, 19.1–26.2%) for grade III/IV hypertension, 7.4% (95%CI, 6.2–8.5%) for grade III/IV proteinuria. In part of RCT, compared to its counterpart, aflibercept containing arm was associated with the increased incidence rate in hypertension (OR:6.30, 95%CI: 3.49–11.36), proteinuria (OR:4.12, 95%CI: 1.25–13.61), epistaxis (OR:3.71, 95%CI: 2.84–4.85), III/IV hypertension (OR:7.20, 95%CI: 5.23–9.92), III/IV proteinuria (OR:5.13, 95%CI: 3.13–8.41). The funnel plot, Begg test and Egger test were carried out on the primary endpoints, III/IV hypertension rate and III/IV proteinuria rate, the result of which detected no obvious publication bias. No significant difference was observed in subgroup analysis in the primary endpoint between the subgroups stratified by treatment line (firstline or non-firstline), chemotherapy regime (FOLFIRI or others) and study design (RCTs or single-arm trials).

Conclusion:
The available evidence suggests that using aflibercept is associated with an increased risk of antiangiogenic adverse events compared with controls. Further studies are needed to investigate this association. In the appropriate clinical scenario, the use of aflibercept in its approved indications remains justified. However, the results of this study should be interpreted with caution, as some of the evidence comes from single-arm clinical trials.
Triple therapy in metastatic hormone-sensitive prostate cancer
Authors: Tsaur Igor , Mirvald Cristian , Surcel Cristian 
Published: September 2023

Purpose of review
Over the last years, there have been striking changes in the management of metastatic hormone-sensitive prostate cancer (mHSPC) based on survival advantage of combining either a new hormonal agent (NHA) or docetaxel (D) with androgen deprivation therapy (ADT). Some of these studies primarily assessing doublet treatment included men who underwent concomitant or sequential treatment with D. Most recently, prospective randomized evidence emerged on this triplet strategy too. We aimed to outline the current data and ongoing trials evaluating the usage of the triplet therapy in male individuals with mHSPC.

Recent findings
Phase III trials PEACE-1 and ARASENS showed that the upfront triplet treatment with ADT+D and either abiraterone acetate or darolutamide outperformed ADT+D in terms of survival, while severe toxicity was mainly driven by D. Importantly, prospective evidence comparing triplet vs. ADT+NHA is still lacking.

Summary
Men with de novo high-volume disease benefit most from the triplet, while in cases with metachronous and/or low-volume disease, survival advantage is still disputable. As efficacy of ADT+NHA does not appear to be substantially amplified by combination with D, those men with a more favorable underlying tumor biology might mostly benefit from this doublet, also taking quality-adjusted survival into account.
Cocreation With Prelicensure Nursing Students of a Simulated Practice Placement
Authors: Salje Joelle 
Published: September 2023

Background:
Cocreation is a collaborative process that uses problem-based learning to construct new initiatives. It has many known benefits associated with innovation in the development of programs, such as by creating simulations based on firsthand experiences.

Methods:
Thirty second-year prelicensure nursing students cocreated simulations and associated lesson plans for a simulated practice placement. They followed a 4-step process described in the article.

Results:
Cocreation combines lecturers' and students' unique skills and knowledge, creating programs based on the unique firsthand experiences of stakeholders. As the students take control of their own workloads, facilitators need to be adaptable in the support they provide, depending on the needs of the students.

Conclusion:
The staged process provided a structure for the students to produce their simulations and lesson plans. The cocreation of the simulated practice placement provided an innovative educational model that supported student development and produced lessons and simulations based on stakeholder need.
Vaccine Hesitancy
Authors: Hekel Barbara E. , Dugger Jennifer , Pullis Bridgette R. , Cron Stanley , Edwards Allison P. 
Published: September 2023

Background:
Many Americans are undecided about or have barriers to receiving vaccines. Complacency, confidence, convenience, misinformation, and disinformation impact vaccine hesitancy (VH).

Problem:
During the COVID-19 pandemic, rates for flu and routine childhood vaccinations declined globally. As vaccination rates decline, the risk of disease outbreaks increases. Nursing students need to be prepared to address VH in the clinical setting.

Approach:
Four simulation experiences were developed to build confidence and competency in the provision of vaccinations and addressing VH. Nursing students practiced communication skills critical to motivational interviewing, health education, health promotion, and goal setting.

Outcome:
There were statistically significant increases in student confidence and perceived competence in vaccine administration and addressing VH through motivational interviewing.

Conclusions:
High-fidelity simulation combined with a virtual simulation was effective in developing confidence among nursing students. Students demonstrated skill in addressing VH and motivational interviewing.
Technical Factors That May Influence mHealth Adherence in Children With Chronic Pulmonary Diseases: Scoping Review
Authors: Sapouna Vaia , Dimitriadis Zacharias , Douros Konstantinos , Kapreli Eleni , Kortianou Eleni A. 
Published: September 2023

Purpose:
To synthesize the technical factors influencing adherence to nonpharmacological treatment (NPhT) in children with chronic pulmonary diseases (CPDs), using mobile health (mHealth) technology.

Methods:
Five electronic databases were searched from inception to October 12, 2022, with terms related to pediatrics, CPDs, adherence, NPhT, and mHealth. The methodological quality was assessed using the Critical Appraisal Skills Programme and the Mixed Methods Appraisal Tool checklist.

Results:
Eleven articles were included. Six major technical themes were supported by the evidence that may influence adherence to NPhT: design and context, technical support/business model, connectivity, free availability, privacy and security, and cultural readiness.

Conclusions:
The design of mHealth applications (apps) should be done according to the needs of pediatric patients. This may mitigate any barriers and potentially foster adherence to the use of the apps.

What This Adds to the Evidence:
Six major technical themes may influence adherence to NPhT in children with chronic respiratory diseases.
Video Abstract: Supplemental digital content available at http://links.lww.com/PPT/A487.
Effect of Active Motor Learning Interventions on Gross Motor Function and Mobility in Children Aged 2 to 6 Years With Bilateral Cerebral Palsy: A Systematic Review and Meta-analysis
Authors: McLeod Kate L. , Thorley Megan , Reedman Sarah E. , Chatfield Mark D. , Sakzewski Leanne 
Published: September 2023

Purpose:
The purpose of this systematic review is to identify evidence-based interventions to promote active motor learning in children aged 2 to 6 years with bilateral cerebral palsy.

Summary of Key Points:
Seven randomized clinical trials of active motor learning interventions targeting gross motor function and mobility were included. Two studies compared context-focused therapy to child-focused therapy. Five studies compared active motor therapy to usual care. Context-focused therapy, child-focused therapy, and active motor therapy were comparable to usual care to improve functional mobility and gross motor function.

Conclusions and Recommendations for Clinical Practice:
There are limited active intervention studies targeting gross motor function for young children with bilateral cerebral palsy. The authors recommend consideration of the clinical good practice guidelines, dosage parameters, and improved reporting methods when implementing active motor learning interventions targeting gross motor function and mobility for children with cerebral palsy.
Psychosocial Outcomes in Nondirected Uterus Donors 1 Y After Donation
Authors: Warren Ann Marie , da Graca Briget , Wall Anji , Powers Mark B. , Saracino Giovanna , Testa Giuliano , Johannesson Liza 
Published: September 2023

Background.
As uterus transplantation transitions to a clinical procedure for women with absolute uterine-factor infertility, transplant centers performing uterus transplantation need information about the experience of living donors. This study examined the psychosocial impact on 17 nondirected uterus donors in the Dallas UtErus Transplant Study 1 y following donation.

Methods.
A prospective longitudinal study was conducted to measure psychosocial outcomes of depression, anxiety, posttraumatic stress, quality of life, and resilience [measured using the Hospital Anxiety and Depression Scale or Patient Health Questionnaire 9-Item, Generalized Anxiety Disorder 7-Item, Posttraumatic Stress Disorder Checklist for the DSM-5, health-related quality of life Short Form-36, and Connor-Davidson Resilience Scale 10-Item, respectively) assessed at baseline, at 6-mo and 1-y follow-up. Differences among baseline, 6-mo, and 1-y postdonation were analyzed.

Results.
The median age was 38.0 y, 16 were married, 15 were of non-Hispanic/Latino ethnicity. Most donors did not report psychosocial distress; however, 1 donor reported decline on the role limitations because of Emotional Problems Scale and also showed an increase in depression symptoms at the 6 mo, but at 1 y was below the clinical cutoff for depression. A second donor showed modest decline in emotional well-being. Improvements were seen in other donors on the Physical Functioning Scale and posttraumatic stress symptoms.

Conclusions.
Although most nondirected donors appeared to remain stable, both positive and negative changes were observed over the first year. Larger studies are needed to determine psychosocial risks and benefit and what additional resources might be needed to ensure optimal psychosocial outcomes.
Identifying X-Chromosome Variants Associated with Age-Related Macular Degeneration
Authors: Grunin Michelle , Igo Robert P. , Song Yeunjoo E , Blanton Susan H , Pericak-Vance Margaret A , Haines Jonathan L. ,   International Age-related Macular Degeneration Genomics Consortium
Published: September 2023

AbstractPurposeIn genome-wide association studies (GWAS), X chromosome (ChrX) variants are often not investigated. Sex-specific effects and ChrX-specific quality control (QC) are needed to examine these effects. Previous analyses identified 52 autosomal variants associated with age-related macular degeneration (AMD) via the International AMD Genomics Consortium (IAMDGC), but did not analyze ChrX. Therefore, our goal was to investigate ChrX variants for association with AMD.MethodsWe genotyped 29,629 non-Hispanic White (NHW) individuals (M/F:10,404/18,865; AMD12,087/14723) via a custom chip and imputed after ChrX-specific QC (XWAS 3.0) using the Michigan Imputation Server. Imputation generated 1,221,623 variants on ChrX. Age, informative PCs, and subphenotyeps were covariates for logistic association analyses with Fishers correction. Gene/pathway analyses were performed with VEGAS, GSEASNP, ICSNPathway, DAVID, and mirPath.ResultsLogistic association on NHW individuals with sex correction, identified variants in/near the genesSLITRK4, ARHGAP6, FGF13andDMDassociated with AMD (P<1x10-6,Fishers combined-corrected). Via association testing of subphenotypes of choroidal neovascularization and geographic atrophy (GA), variants inDMDassociated with GA (P<1x10-6, Fishers combined-corrected). Via gene-based analysis with VEGAS, several genes were associated with AMD (P<0.05, both truncated tail strength/truncated product P) includingSLITRK4andBHLHB9. Pathway analysis using GSEASNP and DAVID showed genes associated with nervous system development (FDR: P:0.02), and blood coagulation (FDR: P:0.03). Variants in the region of a microRNA (miR) were associated with AMD (P<0.05, truncated tail strength/truncated product P). Via DIANA mirPath analysis, downstream targets of miRs show association with brain disorders and fatty acid elongation (P<0.05). A long-non coding RNA on ChrX near theDMDlocus was also associated with AMD (P=4x10-7). Epistatic analysis (t-statistic) for a quantitative trait of AMD vs control including covariates found a suggestive association in theXGgene (P=2x10^-5).ConclusionsAnalysis of ChrX variants demonstrates association with AMD and these variants may be linked to novel pathways. Further analysis is needed to confirm results and to understand their biological significance and relationship with AMD development in worldwide populations.
Generalisability of epileptiform patterns across time and patients
Authors: Karimi-Rouzbahani Hamid , McGonigal Aileen 
Published: September 2023

AbstractComplexity of epileptogenic zone (EZ) localisation contributes to failure of surgical resection to produce seizure freedom. This is to some extent a result of distinct patterns of epileptiform activity between (i.e., interictal) and during seizures (i.e., ictal) and their diversity across patients. This often leads to suboptimal localisation based on inspection of electroencephalography (EEG) features. We asked two open questions. First, whether neural signal reflecting epileptogenicity would be generalisable from interictal to ictal time window within each patient. This would be critical for patients who are monitored in hospital without having a seizure to help with EZ localisation, and more generally for understanding the predictive power of resting state (interictal) EEG data in determining EZ. Second, whether epileptiform patterns would generalise across patients, and if so, which aspects of those patterns are the most generalisable.We used an intracranial EEG dataset that included fifty-five patients with lesional and non-lesional pathology, who had subsequently undergone cortical resection in frontal or temporal lobe with different levels of seizure freedom. We extracted a large set of simple to complex features from stereo-EEG (SEEG) and electrocorticographic (ECoG) neural signals recorded during interictal and ictal time windows. We fed those features to decision tree classifiers for EZ localisation and to quantify the diversity of ictal and interictal epileptiform patterns through a cross-time and cross-patient generalisation procedure.We observed significant evidence (Bayes factor>> 10) for generalisability of patterns from interictal to ictal time windows across patients, which were dominantly reflected in signal power and high-frequency network-based features. Majority of patients showed consistent patterns of epileptogenicity across interictal and ictal time windows, reflected in above-chance area-under-curve (meanAUC =0.6). We observed significant evidence (Bayes factor>> 10) that signal features of epileptogenic regions could generalise across patients in both interictal and ictal time windows with significant evidence for higher generalisability in ictal than interictal time window (meanAUC0.75 vs. 0.59;Bayes factor>> 10). While signal power and moment features were the most contributory to the cross-patient generalisation in the interictal window, signal complexity features were the most contributory in the ictal window.These results provide new insights about features of epileptic neural activity that generalise across interictal-ictal time windows and patients, which can have implications for both qualitative and quantitative EZ localisation. The explainable machine-learning pipeline developed here can guide future developments in epilepsy investigations.
Work Status, Functional Recovery, and Quality of Life of Cardiac Arrest Survivors After Hospital Discharge
Authors: Wu Yi-Wen , Chen Tai-Yuan , Huang Chien-Hua , Chu Yu-Jen , Chen Wei-Ting , Lu Kuan-Ting , Chang Wei-Tien , Ong Hooi-Nee , Chen Wen-Jone , Tsai Min-Shan 
Published: September 2023

AbstractBackgroundTo investigate the work status, neurological recovery, and quality of life of cardiac arrest survivors within 1 year after hospital discharge.MethodsA retrospective single center study included 71 non-traumatic adult cardiac arrest patients between 2017 and 2020, who survived more than 1 year after hospital discharge and agreed to participate the study. Questionnaire interviews through telephone visits were conducted with the enrolled patients, assessing their work status, neurological recovery, and quality of life at 3 months and 1 year after hospital discharge. Additionally, their use of medical services was also collected.ResultsOf the enrolled patients, 67 (94.4%) had a cerebral performance category (CPC) of 1 at discharge and the majority of patients (90.1%) returned home. Sixty-seven patients (94.4%) returned for outpatient visits at a median time of 6 days, 23 patients (32.4%) visited the ER at a median time of 74 days, and 22 patients (31.0%) were readmitted to the hospital at a median time of 58 days. In terms of mobility, self-care, usual activities, pain/discomfort, and health state assessed using the EQ-5D-5L, a significant decrease in impairment was observed from 3 months to 1 year. Moreover, patients demonstrated improved work status as well as improved scores for overall quality of life, general health, physical, psychological, social relations, and environmental status evaluated using the WHOQOL-BREF.ConclusionsWithin 1 year following hospital discharge, a considerable number of cardiac arrest survivors require medical support. However, a continual improvement in work status and quality of life were observed.
Metagenomic analysis of the honey bee queen microbiome reveals low bacterial diversity and Caudoviricetes phages
Authors: Caesar Lilian , Rice Danny W. , McAfee Alison , Underwood Robyn , Tarpy David R. , Foster Leonard J. , Newton Irene L. G. 
Published: September 2023

AbstractIn eusocial insects, the health of the queens – the colony founders and sole reproductive females – is a primary determinant for colony success. Queen failure in the honey beeApis mellifera, for example, is a major concern of beekeepers that annually suffer with colony losses, necessitating a greater knowledge of queen health. Several studies on the microbiome of honey bees have characterized its diversity and shown its importance for the health of worker bees, the female non-reproductive caste. However, the microbiome of workers differs from that of queens, which in comparison is still poorly studied. Thus, direct investigations of the queen microbiome are required to understand colony-level microbiome assembly, functional roles, and evolution. Here we used metagenomics to comprehensively characterize the honey bee queen microbiome. Comparing samples from different geographic locations and breeder sources, we show that the microbiome of queens is mostly shaped by the environment experienced since early life, and is predicted to play roles in breakdown of the diet, and protection from pathogens and xenobiotics. We also reveal the microbiome of queens comprises only four core bacterial species,Apilactobacillus kunkeei,Lactobacillus apis, Bombella apisandCommensalibactersp. Interestingly, in addition to bacteria, we show that bacteriophages infect the queen microbiome, for which Lactobacillaceae are predicted to be the main reservoirs. Together, our results provide the basis to understand the honey bee colony microbiome assemblage, can guide improvements in queen rearing processes, and highlight the importance of bacteriophages for queen microbiome health and microbiome homeostasis in eusocial insects.ImportanceThe queen caste plays a central role for colony success in eusocial insects, as queens lay eggs, and regulate colony behavior and development. Queen failure can cause colonies to collapse, which is one of the major concerns of beekeepers. Thus, understanding of the biology behind the queen’s health is a pressing issue. Previous studies have shown the bee microbiome plays an important role in worker bee health, but little is known about the queen microbiome and its functionin vivo. Here, we characterized the queen microbiome identifying for the first time present species and their putative functions. We show that the queen microbiome have predicted nutritional and protective roles in queen association, and comprises only four consistently present bacterial species. Additionally, we bring to attention the spread of phages in the queen microbiome, which increased in abundance in failing queens and may impact the fate of the colony.