bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influences of specialty identity when implementing a new emergency department in Denmark: a qualitative study
Authors: Kirk Jeanette , Lindstroem Mette Bendtz , Stefánsdóttir Nina Thórný , Andersen Ove , Powell Byron J. , Nilsen Per , Tjørnhøj-Thomsen Tine 
Published: September 2023

Abstract
Background
The Danish Health Authority recommended the implementation of new types of emergency departments. Organizational changes in the hospital sector challenged the role, identity, and autonomy of medical specialists. They tend to identify with their specialty, which can challenge successful implementation of change. However, investigations on specialty identity are rare in implementation science, and how the co-existence of different specialty identities influences the implementation of new emergency departments needs to be explored for the development of tailored implementation strategies. The aim of this study was to examine how medical specialty identity influences collaboration between physicians when implementing a new emergency department in Denmark.
Methods
Qualitative methods in the form of participants’ observations at 13 oilcloth sessions (a micro-simulation method) were conducted followed up by 53 individual semi-structured interviews with participants from the oilcloth sessions. Data were analysed deductively inspired by Social Identity Theory.
Results
The analysis yielded three overarching themes: (1) ongoing creation and re-creation of specialty identity through boundary drawing; (2) social categorization and power relations; and (3) the patient as a boundary object.
Conclusions
Specialty identity is an important determinant of collaboration among physicians when implementing a new emergency department. Specialty identity involves social categorization, which entails ongoing creation and re-creation of boundary drawing and exercising of power among the physicians. In some situations, the patient became a positive boundary object, increasing the possibility for a successful collaboration and supporting successful implementation, but direct expressions of boundaries and mistrust were evident. Both were manifested through a dominating power expressed through social categorization in the form of in- and out-groups and in an “us and them” discourse, which created distance and separation among physicians from different specialties. This distancing and separation became a barrier to the implementation of the new emergency department.
Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon
Authors: Ma Xiaolei , Leon Barbara , Ornelas Elizabeth , Dovala Dustin , Tandeske Laura , Luu Catherine , Pardee Gwynn , Widger Stephania , Solomon Jonathan M. , Beckwith Rohan E.J. , Moser Heinz , Clifton Matthew C. , Wartchow Charles A. 
Published: September 2023

Abstract
The design of cereblon-binding molecular glues (MGs) that selectively recruit a desired protein while excluding teratogenic SALL4 is an area of significant interest when designing therapeutic agents. Previous studies show that SALL4 is degraded in the presence of IKZF1 degraders pomalidomide, and to a lesser extent by CC-220. To expand our understanding of the molecular basis for the interaction of SALL4 with cereblon, we performed biophysical and structural studies demonstrating that SALL4 zinc finger domains one and two (ZF1-2) interact with cereblon (CRBN) in a unique manner. ZF1 interacts with the N-terminal domain of cereblon and ZF2 binds as expected in the C-terminal IMiD-binding domain. Both ZF1 and ZF2 contribute to the potency of the interaction of ZF1-2 with CRBN:MG complexes and the affinities of SALL4 ZF1-2 for the cereblon:CC-220 complex are less potent than for the corresponding pomalidomide complex. Structural analysis provides a rationale for understanding the reduced affinity of SALL4 for cereblon in the presence of CC-220, which engages both ZF1 and ZF2. These studies further our understanding of the molecular glue-mediated interactions of zinc finger-based proteins with cereblon and may provide structural tools for the prospective design of compounds with reduced binding and degradation of SALL4.
Conjunctival Ultraviolet Autofluorescence as a Biomarker of Outdoor Exposure in Myopia: A Systematic Review and Meta-analysis.
Authors: Rodríguez Natali , Claici Aura , Castañeda Jorge , González-Zamora Jorge , Bilbao-Malavé Valentina , Puente Miriam de la , Fernandez-Robredo Patricia , Parra Sandra , Garza-Leon Manuel , Recalde Sergio 
Published: September 2023

Abstract
Outdoor activity (OA) is considered the main modifiable risk factor for myopia development. Quantifying the association between Conjunctival Ultraviolet Autofluorescence (CUVAF) area and OA can be useful as a biomarker for myopia control. The purpose of this study is to quantify the association between CUVAF area and myopia. The articles included populations from different geographic areas (Europe/Asia/Australia) and ages.
The bibliographic research was accomplished between June-August of 2022 with the following databases: MEDLINE/SCIENCE DIRECT/GOOGLE SCHOLAR/WEB OF SCIENCE/SCOPUS with all the terms related of "conjunctival ultraviolet autofluorescence” (2006-2022). Cross-sectional and case-control studies were included. The differences between CUVAF area and the hours of OA performed by myopic and non-myopic patients and the correlation of OA with the size of the CUVAF area were analyzed.
The meta-analysis of the CUVAF area between myopic and non-myopic patients showed statistically smaller areas (-3.30 mm²-CI95%[-5.5;-1.06]). Stratified sub-analysis by different geographic areas showed that Australia-Asia patients showed a greater difference in CUVAF area (-4.92 mm²-CI95%[-9.5;-0.29]) compared to Europe patients (-1.97 mm²;CI95%;-2.8;-1.14, p= 0.007). Myopic reported less OA vs non-myopic (-3.38 hours/week-CI95%[-4.6;-2.09]), and the correlation between CUVAF area and OA was 0.14 (CI95%[0.09;0.19]).
A strong relationship was observed between CUVAF, myopia and OA in different studies and geographic locations. The importance of this validation is that CUVAF is a simple, fast and non-invasive quantitative method to evaluate the control of myopia.
Managed Care Updates of Subscriber Jail Release to Prompt Community Suicide Prevention: Clinical Trial Protocol
Authors: Arias Sarah A. , Sperber Kimberly , Jones Richard , Taxman Faye S. , Miller Ted R. , Zylberfuden Sarah , Weinstock Lauren M. , Brown Gregory K. , Ahmedani Brian , Johnson Jennifer E. 
Published: September 2023

Abstract
Background. Recent jail detention is a marker for trait and state suicide risk in community-based populations. However, healthcare providers are typically unaware that their client was in jail and few post-release suicide prevention efforts exist. This protocol paper describes an effectiveness-implementation trial evaluating community suicide prevention practices triggered by advances in informatics that alert CareSource, a large managed care organization (MCO), when a subscriber is released from jail.
Methods. This randomized controlled trial investigates two evidence-based suicide prevention practices triggered by CareSource’s jail detention/release notifications, in a partial factorial design. The first phase randomizes ~43,000 CareSource subscribers who pass through any Ohio jail to receive Caring Contact letters sent by CareSource or to Usual Care after jail release. The second phase (running simultaneously) involves a subset of ~6,000 of the 43,000 subscribers passing through jail who have been seen in one of 12 contracted behavioral health agencies in the 6 months prior to incarceration in a stepped-wedge design. Agencies will receive: (a) notifications of the client’s jail detention/release, (b) instructions for re-engaging these clients, and (c) training in suicide risk assessment and the Safety Planning Intervention for use at re-engagement. We will track suicide-related and service linkage outcomes 6 months following jail release using claims data.
Conclusions. This design allows us to rigorously test two intervention main effects and their interaction. It also provides valuable information on the effects of system-level change and the scalability of interventions using big data from a MCO to flag jail release and suicide risk.
Trial Registration: The trial is registered at clinicaltrials.gov (NCT05579600). Registered 27 June, 2023,
https://beta.clinicaltrials.gov/study/NCT05579600?cond=Suicide&term=Managed%20Care&rank=1
Baked hydrogel from palm starch and modified chitosan for water contaminant removal
Authors: Restu Witta Kartika , Mawarni Rista Siti , Triwulandari Evi , Ghozali Muhammad , Zahra Tazkia Qonita , Rachmadona Nova , Sugita Purwantiningsih , Agusnar Harry 
Published: September 2023

Abstract
The present study synthesized baked hydrogels by crosslinking reactions from the sugar palm starch and modified chitosan using citric acid as a cross-linker and potassium persulfate as the free radical initiator. Sugar palm starch was derived from the sugar palm (Arenga pinnata) plant, extracted from the stem when it no longer produces sugar and fruits. Baked hydrogels were characterized by their physical and chemical properties, including moisture content, water solubility, swelling capacity, and contact angle. From the variation of the obtained baked hydrogels, the moisture contents varied around 11-15%, water solubility was in the range of 28-38% and the degree of swelling was about 153-283%. In terms of contact angle measurement, the highest value was around 65°. The structure formation of chemical linkages among raw materials of the baked hydrogels was studied using Fourier transform infrared spectroscopy (FTIR). The morphology was observed with scanning electron microscopy (SEM), showing the porosity in the structure. The thermal properties were marked using differential scanning calorimetry (DSC) with a range of glass transition temperature of 47-60°C and melting temperature from 190 to 203°C. In their application as the removal of methylene blue as the targeted water contaminant, the baked hydrogels of HSC 3 can absorb methylene blue solution with the highest degradation percentage, reaching 63.10%. This confirmed that sugar palm starch and modified chitosan in baked hydrogel can be applied in the environment for contaminant removal.
A Human-AI Integrated Rating System for Improving Second Language Writing:The Case of Japanese Learners of English for General Academic Purposes
Authors: Spring Ryan 
Published: September 2023

Abstract

A new English as a foreign language curriculum was introduced at a Japanese university and the teaching of both paragraph and summary writing was mandated. However, many teachers did not evaluate students’ writing citing the number of students and lack of time and they were hesitant to use AI raters as they did not trust or understand the AI’s rating criteria. Therefore, an integrated human-AI rating model was proposed in which AI would rate students’ language use based on understandable criteria and humans would quickly check the AI responses while rating content and structure. A few teachers tried the system and improvements were made based on new data and newly available research. An online practice tool was also created for students so that they could understand how the AI would rate their language use and practice accordingly. The online practice tool and AI rating model was improved over the course of three semesters based on student data and the ratings of external professional raters. As a result, the fairness of writing-rating seemed to improve, an increasing number of teachers used the rating system, and the number of students that practiced writing and were evaluated increased drastically university-wide, which corresponds with adherence to the curriculum and, presumably, to enhanced learning of writing.
Solar Photovoltaic Fed Three-Phase Multifunctional Converter Operation Using a Nonlinear Control Strategy
Authors: Majji Ravi Kumar , Mishra Jyoti Prakash 
Published: September 2023

Abstract
A nonlinear control strategy for a solar photovoltaic (SPV) integrated three-phase multifunctional converter (3PMFC) is proposed in this study. The proposed control strategy encapsulates the Lyapunov function controller (LFC) for the voltage control loop and a model predictive controller (MPC) for the current tracking control loop. The SPV source is integrated into the 3PMFC’s dc-link via a dc-dc boost converter. Aside from injecting active power generated by the SPV into the utility system at the unity power factor, the control algorithm of a 3PMFC includes multifunctional features such as current harmonic compensation, reac-tive power support, and source current balance. The dc-dc boost converter and 3PMFC reference currents are calculated using an incremental conductance-based maximum power point tracking (MPPT) algorithm and a variable conductance factor (VCF) technique, respectively. Furthermore, the MPC algorithm is used to design the current tracking controllers for the dc-dc boost converter and 3PMFC. The effectiveness of the proposed control technique was evaluated using different solar irradiation, dc-loads, and ac-loads (linear balanced, linear unbalanced , and nonlinear loads). Finally, under a dynamic operation scenario, the performance of the proposed control technique is assessed and validated using MATLAB/Simulink and real-time simulator (OPAL-RT OP4510) results.
Risk allocation of old community renewal PPP project in China--An improved TOPSIS approach
Authors: Huo Xiaosen , Xue Hao , Hao Tong , Jiao Liudan 
Published: September 2023

Abstract
To ensure the successful implementation of old community renewal PPP project in China, it is essential to allocate the project risks among the participants appropriately. Therefore, this study aims to determine the optimal risk allocation scheme between the government and the private sector in old community renewal projects. An improved TOPSIS based risk allocation model is introduced to improve the decision-making efficiency in risk allocation, and a case study is carried out in Chongqing to allocate the risk factors in the project. The research findings provide references for allocating risks between the government and the social capital in PPP projects.
Bioactivity Properties of Hydroxyalpatite/clay Nanocomposites
Authors: ANDREW OFUDJE EDWIN , Akande James , Sodiya Ezekiel , AJAYI Gabriel , ADEMOYEGUN Adeniyi 
Published: September 2023

Abstract

The need for bioactive and non-toxic biomaterials is on a high demand in tissue engineering applications nowadays. Hydroxyapatite (HAp) is the chief constituent of teeth and bones in mammas. In this study, HAp and HAp/clay nanocomposites were developed via wet chemical process to mimic natural HAp and to equally confer special properties such as mechanical properties, high surface area, crystallinity, high porosity, and biocompatibility on the biomaterial. The properties of the as-prepared nanocomposites analyzed by FT-IR showed functional groups of HAp and clay such as Al–Al–OH, Si–Si–OH, Si–O, PO43-, -OH, and Si–O–Al. The XRD results confirmed the formation of HAp/clay nanocomposite. SEM and TEM images showed the morphologies of the prepared nanocomposites to be round shape particles. Besides, EDX result revealed the Ca/P ratio of HAp and HAp-C to be lower than that of stoichiometric ratio (1.67) which implies the presence of K, Na, Ca, Mg, Si and Al in the HAp/clay nanocomposite. The mechanical properties of the apatite were greatly enhanced by the addition of clay. Furthermore, proliferation of apatites particles onto the surface of the nanocomposites was observed after treatment with simulated body fluids (SBF) media for seven days. Thus, HAp/clay nanocomposites can be useful biomaterials in bone tissue engineering.
Cell therapy could benefit from BCG: how anti-tumour BCG-primed NK cells selectively proliferate over other lymphocytes and efficiently kill cancer cells
Authors: Vales-Gomez Mar , Felgueres María-José , García-Jiménez Álvaro , Esteso Gloria , Dopazo Ana , Reyburn Hugh , Martínez-Piñeiro Luis , Aguiló Nacho 
Published: September 2023

Abstract
Natural killer (NK) cell-based immunotherapies are safe, promising treatments for patients with cancer. Nevertheless, the short-lived nature of NK cells, the heterogeneity of NK populations and the need to infuse large number of cells for efficient tumour elimination represent important challenges for the development of NK cell-based therapies. Therefore, improved approaches to produce high numbers of long-lived, cytotoxic NK cells are essential for clinical applications. We have previously identified anti-tumour NK cells (CD56highCD16+NKG2A+) generated upon exposure to Bacillus Calmette-Guérin (BCG), an early immunotherapy that has been used for decades to treat bladder cancer. Here, we describe that BCG-primed NK cells (B-pNK) kill a broad range of solid tumours and specifically proliferate, without the need of cell sorting, by weekly stimulations with low doses of cytokines, while BCG and other peripheral blood mononuclear cells decrease in the culture. In depth scRNA-seq analysis showed that B-pNK upregulated IL12, IL15 or IL21 signalling pathways, but not IL18, according to the Reactome database. Consequently, B-pNK cells potently proliferated and enriched over other lymphocytes, after weekly stimulations with this cytokine combination, used in low concentration to avoid overstimulation. Despite NKG2A expression, B-pNK mediated potent anti-tumour activity as demonstrated in functional assays, including degranulation, specific cytotoxicity and intracellular-cytokine release, being NKG2D the main activating receptor involved in tumour recognition and elimination. We propose that a strategy based on BCG-priming of NK cells provides a scalable and economical approach for the development of safe and universal cellular immunotherapies against solid tumours.
Spatio-temporal Characterization of Drought Variability in Data-Scarce Regions Using Global Precipitation Data: A Case Study in Cauto River Basin, Cuba
Authors: Tran Anh Phuong , Tran Bao Chung , Campbell Siliennis Blanco , Nguyen Nam Anh , Tran Dieu Hang , Nguyen Thanh Thuy , Nguyen Anh Duc , Son Duong Hong 
Published: September 2023

Abstract
Drought is considered as the most severe water-related disaster in the Cauto river basin, which is the longest river and the main agricultural producer in Cuba. Better understanding on drought characteristics is crucial to implementing drought management plans. Given the sparsity of ground-based precipitation observations in the Cauto, this study aims at using gridded global precipitation to analyze the spatio-temporal variation of drought in this river basin. Firstly, the monthly Climate Hazards Group InfraRed Precipitation with Station data (CHIRPS) in the 1981–2023 period was calibrated with the gauged precipitation using the Thiessen polygon-based method and linear least squares regression equations. Then, the gridded standardized precipitation index (SPI) with time scales of 3, 6, 9 months and drought characteristics, namely, drought frequency, duration and intensity were calculated from the calibrated CHIRPS precipitation. Finally, the spatio-temporal analysis was performed to investigate the trends and variation of drought in the Cauto river basin in time and space. The obtained results shows that the calibrated CHIRPS precipitation is highly consistent with the gauged observations and is capable to determine the magnitude, time and spatial extend of drought events in the Cauto river basin. The trend analysis by the Mann-Kendall test reveals that although the trend is not statistically significant, the SPI tends to decrease with time in the dry season, which indicates the more severe drought. The spatial analysis indicates that the lower region of the Cauto river basin is suffered from longer drought duration and higher drought intensity than the upper one. This study expresses the importance of open global precipitation data sources in monitoring and quantifying drought characteristics in data-scarce regions.
An ethnobotanical study of wild edible plants used by the Tibetan in the Rongjia river valley, Tibet, China
Authors: Wang Jin , Ding Xiaoyong , Guo Chang-An , Zhang Xiong , Feng Haowen , Yang Huizhao , Wang Yuhua 
Published: September 2023

Abstract
Background
Wild edible plants (It is abbreviated as WEPs below) play a crucial role in communities with limited communication with the outside world, where unstable factors like poor food supply and insufficient access to timely nutritional supplementation are common, such as the Himalaya region. To document the traditional WEPs knowledge and explore the significance of WEPs for communities with minimal global economic exchange, an ethnobotanical study was conducted in Rongjia Town which lies in a narrow valley near Mount Everest, Tibet, China.
Methods
This ethnobotanical study was conducted in three villages in Rongjia river valley between August 2021 to June 2023. Semi-structured interviews and participatory observations were used to collect the WEPs and related knowledge. The field works were performed with the assistance of local guides. We collected voucher specimens for each documented plant species for taxonomic identification. In this study, we use relative frequency of citation (RFC) to evaluate the comprehensive utilization value of WEPs.
Results
We interviewed 161 informants who provided us with 2499 use reports. In total, we collected 50 WEPs belonging to 28 families and 42 genera used by Tibetan people in Rongjia river valley. The WEPs are used as vegetable, fruit, seasoning, healthcare food, substitute grain and beverage. Among them, wild vegetable is the most commonly used categories, followed by wild fruit. And leaf is the most commonly consumed parts. The top three important WEPs are Rosa sericea f. glandulosa, Zanthoxylum bungeanum and Urtica hyperborea. Other than that, we also documented the current use situation of WEPs. The results shows that while some plants that were once important substitute grains are no longer used, these plants remain vivid in the memories of older people.
Conclusions
WEPs provided wild vegetable, fruit, seasoning, healthcare food, and ubstitute grain for Tibetan people in Rongjia river valley. And some WEPs become a important cultural carrier of older people, which can help to understand the relation of plant and local people in the past. In addition, WEPs can still increase resilience for local people lived in remote area when they face sudden destabilizing events in the future. Therefore, we suggest that future studies should focus more on WEPs in communities with limited communication with the world in order to improve their resilience.
Metabolomics reveals the importance of metabolites in Mussaenda pubescens for antioxidant properties and quality traits
Authors: Zhou Caibi , Li Ping , Fu Shanshan , You Yan , Guo Sijian , Piyaporn Chueamchaitrakun , Mei Xin , Zhou Xiaolu , Girdthai Teerayoot 
Published: September 2023

Abstract

Background
Mussaenda pubescens is an important source of medicinal plant that has been used as medicine or dried instead of tea. However, there are few studies on the thorough and dynamic assessment of metabolites presented in Mussaenda pubescens.
Methods In this study, UHPLC-MS/MS approach and biochemical analysis were used to investigate the substance changes of leaves at different developmental stages.
Result A total of 957 metabolites were identified, among which 202, 54 and 254 metabolites showed differential accumulation in three comparisons. The up-regulated metabolites were the major factors driving the function and quality of Mussaenda pubescens. The main pathways involved “Flavone and flavonol biosynthesis”, “Phenylalanine metabolism”, “ABC transporters”, “Folate biosynthesis”, and “Fructose and mannose metabolism”. Phenolics, flavonoids, terpenoids and anthocyanin were the primary contributors to differential antioxidant activities of bud, tender, and mature leaves.
Conclusions These results provide a novel insight into formation mechanism of metabolites and the development of Mussaenda pubescenstea.