bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Intra-Articular Botulinum Toxin A Injection for Knee Osteoarthritis
Authors: Ismiarto Yoyos Dias , Prasetiyo Gregorius Thomas 
Published: February 2023

Background:
Botulinum toxin A has the potential to be used for analgesia because of its anti-inflammatory effect. The utility of intra-articular injections of botulinum toxin A for knee osteoarthritis remains unclear. The aim of this study was to analyze the utility of such injections in knees with osteoarthritis.

Methods:
We conducted a literature search of 4 databases (Scopus, PubMed, ClinicalTrials.gov, and Europe PMC) up to September 10, 2022, using formulated keywords. Articles were included in the study if they had data on botulinum toxin A injection compared with the control group in patients with osteoarthritis of the knee. Results were summarized using the standardized mean difference (SMD) and accompanying 95% confidence interval (CI).

Results:
Pooled analysis of data from 6 trials involving 446 patients with knee osteoarthritis revealed that, compared with placebo, intra-articular injection of botulinum toxin A was associated with greater reductions in early visual analog scale (VAS) pain (SMD, −0.63 [95% CI, −1.08 to −0.18], p = 0.007, I2 = 79%), late VAS pain (SMD, −0.57 [95% CI, −1.07 to −0.08], p = 0.02, I2 = 81%), early Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) (SMD, −0.84 [95% CI, −1.61 to −0.06], p = 0.03, I2 = 90%), and late WOMAC (SMD, −1.12 [95% CI, −1.91 to −0.32], p = 0.006, I2 = 93%) scores from baseline in patients with knee osteoarthritis.

Conclusions:
Intra-articular injection of botulinum toxin A may offer benefits in reducing pain and improving function in patients with knee osteoarthritis, with a relatively good safety profile. Larger randomized trials are warranted to confirm the results of our study.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Produced Water Management and Utilization: Challenges and Future Directions
Authors: Eyitayo S. I. , Watson M. C. , Kolawole O. 
Published: February 2023

Summary
Produced water (PW) is an undesirable byproduct generated from oil and natural gas production. Due to the large volume produced, managing its disposal is challenging. Generally, PW is used internally for oil and gas operations while different types of means dispose of the remaining volumes. Recently, there has been a need to repurpose the volume of water customarily disposed of for other industries’ applications. This presents a potential opportunity to reduce excessive freshwater usage in oil and gas operations and reduce water depletion in other industries, thus aiding water conservation as one of the goals for sustainable development. While the external uses are the viable and logical solution, there are challenges relating to PW characterization, treatment technology, and economics of such a project. Therefore, the effective treatment technology, utilization, and disposal of PW remain critical issues for the petroleum industry with consideration of the environment, technical aspects, and economics. There must be collaboration among all stakeholders to harness the potential opportunities and merits of external reuse of PW for cost-effective and environmentally sustainable solutions in treatment technology and every other aspect of PW management. This review presents a comprehensive overview of PW management, current practices in the petroleum industry, and opportunities to be used in other sectors. A detailed account of each disposal method and possible external uses are enumerated with associated challenges, and how these can be mitigated.
GPX4 is a potential biomarker and is associated with the diagnosis and treatment of diffuse large B lymphoma and B cell immune infiltration
Authors: Li Tong-Yu , Li Yun 
Published: February 2023

Abstract
A large amount of evidence shows that the dysregulated expression of iron death plays a key role in cancer biology. GPX4 is a key gene for iron death and a risk factor for many cancers. However, the role of GPX4 in the genesis, development and immune process of diffuse large B lymphoma (DLBCL) has rarely been reported. The purpose of this study was to explore the significance of GPX4 in the diagnosis, prognosis and immune correlation of DLBCL. TNMplot, GSCA, TIMER 2.0, GEPIA and GEO databases were used to analyze the expression level of GPX4 and evaluate the prognosis. Metascape was used for enrichment analysis to study potential biological pathways. Finally, we used TIMER to explore the correlation between GPX4 and tumor infiltrating immune cells. GPX4 is expressed differently in various cancers. Compared with normal tissues, it is also significantly up-regulated in DLBCL tissues, and is related to the prognosis of DLBCL. In addition, enrichment analysis shows that GPX4 has a functional relationship with Glutathione peroxidase activity, Arachidonic acid metabolism, Leukotriene metabolic process, and Reactive oxygen species metabolic process. At the same time, we found that GPX4 has a significant correlation with CDCA7.
Stratospheric water vapor affecting atmospheric circulation
Authors: Charlesworth Edward , Ploeger Felix , Birner Thomas , Baikhadzhaev Rasul , Abalos Marta , Abraham Luke , Akiyoshi Hideharu , Bekki Slimane , Dennison Fraser , Jöckel Patrick , Keeble James , Kinnison Douglas , Morgenstern Olaf , Plummer David , Rozanov Eugene , Strode Sarah , Zeng Guang , Riese Martin 
Published: February 2023

Abstract
Water vapor plays an important role in many aspects of the climate system, by
affecting radiation, cloud formation, atmospheric chemistry and dynamics.
Even the low stratospheric water vapor content provides
an important climate feedback, but current climate models show a substantial
moist bias in the lowermost stratosphere.
Here we report crucial sensitivity of the atmospheric circulation in the stratosphere
and troposphere to the abundance of water vapor in the lowermost stratosphere.
We show from a mechanistic climate model experiment and inter-model variability
that lowermost stratospheric water vapor decreases local temperatures, and
thereby causes an upward and poleward shift of subtropical jets, a strengthening of the
stratospheric circulation, a poleward shift of the tropospheric eddy-driven jet and
regional climate impacts. The mechanistic model experiment in combination with atmospheric observations
further shows that the prevailing moist bias in current models is likely caused by the transport scheme, and can be alleviated by employing a less diffusive Lagrangian scheme.
The related effects on atmospheric circulation are of similar magnitude as climate change effects.
Hence, lowermost stratospheric water vapor exerts a first order effect on
atmospheric circulation and improving its representation in models
offers promising prospects for future research.
Optically-boosted planar IBC Solar Cells with Electrically-harmless Photonic Nanocoatings
Authors: Santos Ivan , Alexandre Miguel , Mihailetchi Valentin , Mateus Tiago , Mouquinho Ana , Boane Jenny , Vicente António , Nunes Daniela , Menda Ugur , Águas Hugo , Fortunato Elvira , Martins Rodrigo , Mendes Manuel J. 
Published: February 2023

Abstract
Advanced light management via front-coated photonic nanostructures is a promising strategy to enhance photovoltaic efficiency through wave-optical light-trapping effects, avoiding the conventional texturing processes that induce the degradation of electrical performance due to increased carrier recombination.
Here, TiO2 honeycomb arrays with different geometry were engineered through a highly-scalable colloidal lithography method on flat crystalline silicon (c-Si) wafers and tested on standard planar c-Si interdigitated back-contact solar cells (pIBCSCs). The photonic-structured wafers achieved an optical photocurrent of 36.6 mA/cm2, mainly due to a broad anti-reflection effect arising from the 693 nm thick nanostructured coatings; whereas the pIBCSC test devices reached 14% efficiency with 705 nm thick TiO2 nanostructures, which corresponds to ~30% efficiency gain relative to uncoated pIBCSCs. In addition, several designed structures showed unmatched angular acceptance enhancements in efficiency (up to 63% gain) and photocurrent density (up to 68% gain).
The high-performing (yet electrically harmless) light-trapping scheme, here presented, entails a highly promising alternative to conventional texturing for c-Si technological improvement, with straightforward integration in the established photovoltaic industry.
A Kernel Search Algorithm for Virtual Machine Consolidation Problem in Cloud Computing
Authors: Luo Jiang-Yao , Yuan Jian-Hua 
Published: February 2023

Abstract
Virtual machine consolidation describes the process of reallocation of virtual machines (VMs) on a set of target servers. It can be formulated as a mixed integer linear programming problem which is proven to be an NP-hard problem. In this paper, we propose a kernel search (KS) heuristic algorithm based on hard variable fixing to quickly obtain a high-quality solution for large-scale virtual machine consolidation problems (VMCPs). Since variable fixing strategies in existing KS works may make VMCP infeasible, our proposed KS algorithm employs a more efficient strategy to choose a set of fixed variables according to the corresponding reduced cost. Numerical results on VMCP instances demonstrate that our proposed KS algorithm significantly outperforms the state-of-the-art mixed integer linear programming solver in terms of CPU time, and our proposed strategy of variable fixing significantly improves the efficiency of the KS algorithm as well as the degradation of solution quality can be negligible.
Assessment of rehabilitation following subarachnoid haemorrhage in China: Findings from the Chinese Stroke Center Alliance
Authors: Chen Yi-Tong , Wu Mei-Ru , Li Zi-Xiao , Gu Hong-Qiu , Zhou Qi , Wang Dan-Dan , Wang Yong-Jun , Zhao Xing-Quan 
Published: February 2023

Abstract
Background: Rehabilitation improves functional recovery in subarachnoid hemorrhage (SAH) patients, and assessing patients for rehabilitation is the first step in this process. However, little is known about clinical practice in China regarding the assessment and provision of rehabilitation for patients with SAH.
Methods: To identify patients hospitalized with SAH and to analyze rehabilitation assessment rates, we used data for 11,234 SAH patients admitted to 861 hospitals from the China Stroke Center Alliance from August 2015 to July 2019. We examined factors for rehabilitation assessment and analyzed the relationship between rehabilitation assessment and outcomes in these patients.
Results: Among 11,234 patients with SAH, 6,513 (58.0%) were assessed for rehabilitation. Assessed patients had an increased length of stay (mean±SD days: 17.3±12.5 versus 11.6±10.5, P=49.4), a higher Glasgow Coma Scale (GCS) score on admission (mean±SD GCS score: 12.3±3.8 versus 11.8±4.4, P=12.2), and were more likely to be admitted to the stroke unit (19.6% versus 13.8%, P=15.6). In multivariable analysis, factors associated with an increased likelihood of a rehabilitation assessment (p < 0.05) included a longer length of stay (odds ratio [OR], 1.04; 95% confidence interval (CI), 1.04 to 1.05) and care such as dysphagia screening (OR, 1.88; 95% CI, 1.73 to 2.04), DVT prophylaxis (OR, 1.56; 95% CI, 1.41 to 1.72) and vessel evaluation (OR, 1.80; 95% CI, 1.63 to 1.98). For the multivariate analysis of outcomes, patients undergoing rehabilitation assessment had a longer length of stay (OR, 1.96; 95% CI, 1.81 to 2.12), a higher modified Rankin Scale (mRS) score at discharge (OR, 1.49; 95% CI, 1.36 to 1.64), and higher rates of discharge to a rehabilitation center (OR, 3.23; 95% CI, 1.81-5.75).
Conclusion: More than two-fifths of SAH patients were not assessed for rehabilitation. Rates vary considerably among hospital grades, and there is a need to improve adherence to recommended care for SAH patients.
Extrapedicular vs transpedicular percutaneous kyphoplasty for osteoporotic vertebral compression fractures: A systematic review and meta-analysis
Authors: WU Fan , Huang Zhi-hui , Li Zhi-gang , Liang De , Jiang Xiaobing 
Published: February 2023

Abstract
Background: Osteoporotic Vertebral Compression Fractures(OVCFs) is one of the most common health problems in the elderly population. Percutaneous kyphoplasty is a minimally invasive technique that has gained widespread recognition. Transpedicular and extrapedicular are two approaches for kyphoplasty. But over the last decade, the safety and effect of two approaches remain unclear, and there is still a lack if evaluation of their therapeutic effects.
Objectives: To assess the efficacy and safety of the two approaches as a treatment for patients with OVCF.
Search strategy: We searched CENTRAL; MEDLINE; EMBASE; Chinese Biological Medicine Database; VIP Journals Database; Wan-fang database; CNKI and Chinese Evidence-Based Medicine Database from the their inception to December 2020 in both English and Chinese.We hand searched Chinese language journals and conference proceedings.
Selection criteria: Randomised-controlled trials that compared any form of the transpedicular approachto any form of the extrapedicular approach control intervention in the treatment of osteoporotic vertebral compression fracture patients were included.
Data collection and analysis: Two review authors(Wu F,Huang ZH)independently determined the studies to be included in the review based on inclusion and exclusion criteria and the exracted data were analysed by RevMan 5.3, and the level of evidence was assessed by the GRADE system.
Results: Six randomised controlled trials with a total sample size of 395 patients were included, all of them were from Asian countries. Meta-analysis showed that the extrapedicular approach kyphoplasty is superior to the transpedicular approach kyphoplasty for the less radiology exposure time, less cement volume and a lower leakage rate. But there is no difference between the extrapedicular approach kyphoplasty and the transpedicular approach kyphoplasty with postoperative VAS scores and ODI scores.
Limitations: Only 6 randomized controlled trials were selected for analysis, all of studies all published in Chinese, so there may be difficult for English readers to assess. Heterogeneity was detected among the studies when we pooled the outcomes.
Conclusion: Based on the evidence of 6 RCTs, the effectiveness of extrapedicular kyphoplasty for the treatment of osteoporotic vertebral compression fracture patients is suggestive. Extrapedicular kyphoplasty have less radiology exposure time, cement volume and a lower leakage rate than transpedicular kyphoplasty, and there is no significant different in VAS and ODI after surgery. With the methodological quality and the small number of the included studies taken into consideration, further more high quality and large scale randomized controlled trials are needed.
Daily Scale Streamflow Forecasting Based-Hybrid Gradient Boosting Machine Learning Model
Authors: kilinc huseyin cagan , Ahmadianfar Iman , Demir Vahdettin , Heddam Salim , Al-Areeq Ahmed M. , Abba Sani I. , Tan Mou Leong , Halder Bijay , Marhoon Haydar Abdulameer , Yaseen Zaher Mundher 
Published: February 2023

Abstract
Hybrid model selection built with models based on machine learning (ML) and Deep learning (DL) has a significant impact on river flow predictions. Sustainable use of water resources is possible with the evaluation of basin management principles, effective natural resource management and correct water resources planning. These conditions require accurate estimation of the flows of rivers in the basin. In this study, river flow estimation was made with daily streamflow data from E12A057 (Adatepe), E12A24 (Aktaş) and E12A22 (Rüstümköy) flow measurement stations (FMSs) determined on the critical points of Sakarya Basin, which is among the important basins of Turkey. For three stations, 10 years of flow data obtained from EIEI (General Directorate of Electrical Works Survey Administration) were used. In addition, a method combining the GA-CatBoost model was proposed, which aimed to improve the performance of flow estimation. The performance of the hybrid model was compared to the CatBoost, Long-Short Term Memory (LSTM) and Linear Regression (LR) models. To analyze the performance of the model, the first 80% of the data was used for training and the remaining 20% ​​for testing the three FMS. The results revealed that the proposed hybrid model can adapt nicely with the high nonlinearity of the river flow estimation. It has been observed that the hybrid model was superior to other models in statistical measurement metrics used in the study.
Effects of exposure to incense smoke associated with impaired lung function and respiratory disease: A Systematic Review
Authors: Adnyana I Made Dwi Mertha , Utomo Budi , Dewanti Linda , Fauziyah Shifa , Eljatin Dwinka Syafira , Setyawan Muhamad Frendy , Sumah Lesty Helda Marsel , Karina Citra Al 
Published: February 2023

Abstract
Incense (bakhour) is used by the community through ceremonies, traditional health practices, and aromatherapy. Nevertheless, evidence from experiments and studies of populations suggests that a habit of burning incense makes the lungs work less well. The study investigated the relationship between exposure to incense smoke and impaired lung function and respiratory diseases. Data tracing was carried out systematically by following PRISMA guidelines and establishing inclusion and exclusion criteria for filtering, selecting, and including articles registered in the PROSPERO database. This study describes respiratory symptoms/ diseases, home use of incense, and lung function measurement.Six articles were included; 6 articles (100%) reported using incense indoors, and five (83%) reported using incense outside the home. Respiratory symptoms and diseases caused by exposure to incense sticks are 5 (83%) shortness of breath, 6 (100%) wheezing, asthma, and inflammation of the lungs, 2 (33%) chronic obstructive pulmonary disease, and 4 (67%) allergic rhinitis. Incense smoke particles decrease lung function based on FVC, FEV, PEFR, and FEF values of 25-75%. The results indicate that smoking incense adversely affects lung function and leads to respiratory diseases. The community and related parties can minimize and conduct education and prevention related to simultaneous incense exposure in the community to reduce the burden of diseases and disorders due to respiratory incense smoke in areas that use it daily.
Approximate Solutions of Spray-induced Stress and its Characteristic Analysis in High Winds
Authors: Zhang Ting 
Published: February 2023

Abstract
A great number of spray droplets comprising liquid droplets produce in high winds, which may play a significant role in meteorological and oceanographical processes. In this study, the approximate solutions of the spray-induced stress are calculated based on three different sea-spray generation functions. It’s revealed that there is no evident difference among the calculated results in conditions of both the 10-m wind speed less than 18 m s− 1 and wave age less than 0.6. However, as wind enforces and waves develop, the sea-spray generation function fitted by the field observational data could make the calculated spray-induced stress much larger than the others. It’s also indicated that the wind speed more effectively determines the magnitude of the spray-induced stress compared with wave ages. Then, considering a super typhoon that occurred in the northwest Pacific Ocean, the calculation for the temporal and spatial characteristics of the spray-induced stress is conducted using the fifth-generation ECMWF (i.e., European Centre for Medium-Range Weather Forecasts) reanalysis datasets. The results show that both the magnitude and gradient of the spray-induced stress near the cyclone centre reached the maximum during the super typhoon. At this moment, the spray-induced stress quickly decreased in the area far away from the cyclone centre. It’s also found that the spray-induced stress could reduce the air-turbulent stress for 10-m wind speeds exceeding 18 m s− 1.
Glucagon-like peptide-1 inhibits the progression of abdominal aortic aneurysm in mice:The earlier the better
Authors: Zhao Xinghan , Cheng Zhang , Zhang Hongbo , Guo Yingkun , Zhao Lei , Zhang Chen , Ye Pengfei , Zhang Kun , Ma Xiaohai , Wu Qihong 
Published: February 2023

Abstract
ObjectivesGlucagon‑like peptide‑1 (GLP-1) has a cardiovascular-protective effect in preventing Abdominal Aortic Aneurysm (AAA) formation. However, the administration time to maximize the optimal effect has not been determined. We conducted this study to determine whether the GLP-1 receptor agonist, liraglutide, inhibited AAA progression of mice more efficiently during the earlier stages.
Methods Mice were treated with 300ug/kg/day liraglutide 7, 14 and 28 days after aneurysm preparation. The morphology of abdominal aorta were followed up with 7.0 T magnetic resonance imaging (MRI) during the liraglutide administration. 28 days after administration, the AAA dilatation ratio calculation and histopathological examination were then conducted. Oxidative stress levels were evaluated by the expression of malondialdehyde (MDA). The inflammatory responses were also determined.
Results Treatment with liraglutide decreased AAA formation. Specifically, expansion of the abdominal aorta, elastin lamina degradation and vascular inflammation by leukocyte infiltration decreased. Additionally, MDA expression and matrix metalloproteinase (MMP) activity reduced. Furthermore, the dilatation rate of aortic, MDA expression, leukocyte infiltration, and MMPs activity in the vascular wall decreased significantly in early stage.
Conclusions GLP-1 treatment inhibited AAA progression in mice through its anti-inflammatory and anti-oxidant effects, especially during the earlier stages of AAA formation. Thus, GLP-1 may be a potential pharmacological target for AAA treatment.