bluuebunny/crossref_metadata_2025_split huggingface dataset:
MXene‐based dual‐network conductive organic hydrogel for wearable sensor to monitor human motions
Authors: Zeng Jiawei , Qian Hongxiang , Jia Runping , Mengting Xu , Shuai Wang , Xiaowei Xu , Shufang Chang , Dandan Wu , Jichao Shi , Sheng Han 
Published: June 2023

AbstractConductive hydrogel is a novel material that can be used to prepare flexible wearable strain sensors. It paves the way for future uses in electronic skin, human‐computer interaction, and personalized medical monitoring. However, because the majority of conductive hydrogels use pure water as their medium, they will freeze at low temperatures. It will inevitably lose water at room temperature. We developed a PAM/SA/MXene organic hydrogel (denoted as PSMOH). First, MXene nanosheets were added as conductive filler into the double network polymer hydrogel, which was composed of polyacrylamide (PAM) and sodium alginate (SA), we denoted as PSMH. And then immerse the prepared PSMH in a glycerol solution using a solvent displacement method to obtain PSMOH. Even if at extreme temperatures (−30°C), the prepared PSMOH has a strong antifreezing ability and can retain moisture for 8 days. The sensor also has excellent mechanical properties (tensile strain is 1579%), self‐adhesive property, excellent sensitivity (gauge factor is 49.92), low detection limit (1% strain), and excellent fatigue resistance (800 cycles at 30% strain). As a result, the hydrogel can be assembled into a flexible wearable sensor for real‐time monitoring of human motions and other activities.
Preparation of CO2 responsive cellulose composite adsorbent and its application in protein separation
Authors: Zhang Shoucun , Bian Yujing , Yan Xueyin , Fang Guoli , Guo Shengwei 
Published: June 2023

AbstractThe separation of the proteins is of great theoretical and practical importance for biotechnological application. Considering the requirement of non‐destructive separation, the stimulus–response method is an alternative to the separation of protein. In this work, a cellulose‐based composite with CO2 stimulus–response property is prepared by a simple coprecipitation of poly (N, Nˊ‐diethylamino ethyl methacrylate)‐co‐poly (hydroxyethyl methacrylate) (PDH) and cellulose mixture solution. Subsequently, these composites as the adsorption medium are used to separate the bovine serum albumin (BSA, as the model protein) from solution through stimulus–response course (by CO2/N2 alternation). The results indicate that the ratio of the copolymers/cellulose composite have an obvious effect on the separation of BSA. The average maximum adsorption capacity can get to 562.6 mg/g, and the composites exhibits good adsorption/desorption cycling characteristics. After the composite materials are cycled for three times, the adsorption capacity can still decrease to 300 mg/g. Due to its high adsorption capacity and low preparation cost, the composite is expected to be widely used in industry.
BCL11B expression in hepatocellular carcinoma relates to chemosensitivity and clinical prognosis
Authors: Abe Hiroyuki , Kamimura Kenya , Okuda Shujiro , Watanabe Yu , Inoue Jun , Aoyagi Yutaka , Wakai Toshifumi , Kominami Ryo , Terai Shuji 
Published: June 2023

AbstractIntroductionB‐cell lymphoma/leukemia 11B (BCL11B) is a subunit of SWI/SNF chromatin remodeling complexes and functions in cell cycle regulation and apoptosis upon DNA replication stress and damages via transcription. Many malignancies were reported to exhibit changes in BCL11B gene expression; however, no study has focused on the relationship between BCL11B and hepatocellular carcinoma, which potentially exhibits DNA replication stress and damages upon its oncogenesis. Thus, in this study, we examined the molecular characterization of BCL11B expression in hepatocellular carcinoma.Methods and ResultsThe cumulative progression‐free survival and overall survival were significantly longer in the clinical cases of BCL11B‐negative hepatocellular carcinoma than BCL11B‐positve cases. Microarray and real‐time PCR analyses in hepatocellular carcinoma cell lines indicated a correlation between BCL11B and GATA6, a gene reported to be correlated with oncogenic activities and resistance to anthracycline, which is often used for hepatocellular carcinoma chemotherapy. Consequently, BCL11B‐overexpressing cell lines exhibited resistance to anthracycline in cell growth assays and the resistance has been evidenced by the increased expression of BCL‐xL in cell lines. The results were supported by the analyses of human HCC samples showing the correlation between BCL11B and GATA6 expressions.Discussions and ConclusionOur results indicated that overexpression of BCL11B amplifies GATA6 expression in hepatocellular carcinoma in vitro and in vivo that leads to anti‐apoptotic signal activation, and induces resistance to chemotherapy, which influenced the postoperative prognosis.
A case of splenogonadal fusion in the left testis
Authors: Zhou Ting 
Published: June 2023

Key Clinical MessageSplenic tissue outside the normal anatomical site can be collectively referred to as ectopic spleen. Clinically, the commonest causes of ectopic spleen include accessory spleen, splenic tissue implantation, and splenogonadal fusion (SGF). Accessory spleen is mostly caused by congenital dysplasia, is mostly located near the spleen, and may be supplied by the splenic artery. Splenic implantation is mostly caused by autologous spleen tissue transplantation caused by trauma or surgery. SGF is the abnormal fusion of the spleen with the gonad or with the mesonephric derivatives. As a rare developmental malformation, it is difficult to make a correct diagnosis preoperatively, and easily misdiagnosed as a testicular tumor cause lifelong harm to patients. An 18‐year‐old male student who developed left testicular pain without obvious cause that radiated to the perineum 4 months prior to presentation. He was diagnosed with cryptorchidism 12 years ago and underwent orchiopexy without intraoperative frozen section examination. An ultrasound was performed, identifying hypoechoic nodules in the left testis, suggestive of seminoma. During surgery, the testicular tumor revealed a dark red tissue and the diagnosis of a pathological ectopic splenic tissue was made. Because the clinical manifestations of SGF are not specific, misdiagnosis and unnecessary orchiectomy may occur. If a complete preoperative examination which includes biopsy or intraoperative frozen section is performed, unnecessary orchiectomy can be effectively avoided and bilateral fertility can be preserved.
Modelling of a vacuum residue hydrocracking in an industrial slurry phase reactor
Authors: Mishra Praneet , Yadav Ashutosh 
Published: June 2023

AbstractThe upgradation of the bottom of the barrel has gained much interest across the refineries due to severe environmental rules, limitations of conventional oil reserves, and its flexibility to produce light end products which benefit end users. Slurry phase hydrocracking is one of the growing technologies to fulfil the increasing demand for light cut. Modelling of an industrial slurry phase reactor (SPR) for vacuum residue hydrocracking using different kinetic models is proposed. The axial dispersion model (ADM) is used for modelling an industrial SPR. The mathematical model of the reactors is incorporated for the three different lump kinetic models. This study deals with the continuous stirred tank reactor (CSTR) and SPR modelling, followed by industrial SPR modelling. The small lab‐scale reactor models are validated with the experimental data reported in the literature. The study's objective was to investigate the one‐dimensional and two‐dimensional concentration dynamics of each lump along the axial and radial positions of industrial SPR. The vacuum residue conversion into the light fractions was obtained by more than 73% in industrial SPR. Also, the yield of vacuum gas oil and resins were evaluated as 49% and 63%, respectively. The sensitivity analysis was performed to explain the effect of process variables. The optimum range was found as a length of 15 m, liquid hourly space velocity (LHSV) of 0.2 h−1, 1% catalyst concentration, and 420°C reaction temperature to enhance the throughput of the reactor.
Inhibitors of Aspartate Transcarbamoylase Inhibit Mycobacterium tuberculosis Growth
Authors: Du Xiaochen , Sonawane Vidhisha , Zhang Bidong , Wang Chao , de Ruijter Bram , Dömling Alexander S. S. , Reiling Norbert , Groves Matthew R. 
Published: June 2023

AbstractAspartate transcarbamoylase (ATCase) plays a key role in the second step of de novo pyrimidine biosynthesis in eukaryotes and has been proposed to be a target to suppress cell proliferation in E. coli, human cells and the malarial parasite. We hypothesized that a library of ATCase inhibitors developed for malarial ATCase (PfATCase) may also contain inhibitors of the tubercular ATCase and provide a similar inhibition of cellular proliferation. Of the 70 compounds screened, 10 showed single‐digit micromolar inhibition in an in vitro activity assay and were tested for their effect on M. tuberculosis cell growth in culture. The most promising compound demonstrated a MIC90 of 4 μM. A model of MtbATCase was generated using the experimental coordinates of PfATCase. In silico docking experiments showed this compound can occupy a similar allosteric pocket on MtbATCase to that seen on PfATCase, explaining the observed species selectivity seen for this compound series.
Use of nongynecologic cytologic–histologic correlation to identify patterns of error: An institutional experience
Authors: O’Conor Christopher J. , Dehan Lauren M. , Ely Kim A. 
Published: June 2023

AbstractBackgroundQuality management practices empower cytology laboratories to deliver consistent, high‐quality patient care. Monitoring of key performance indicators is one way by which laboratories can identify patterns of error and focus their improvement activities. Cytologic–histologic correlation (CHC) identifies error by retrospectively reviewing cytology cases when discordant surgical pathology diagnoses are reported. Analysis of CHC data can elucidate patterns of error and direct quality improvement initiatives.MethodsCHC data of nongynecologic cytology specimens were reviewed over a 3‐year period (2018–2021). Errors were separated by anatomic site and classified as either sampling or interpretive errors.ResultsA total of 364 discordant cases were identified out of 4422 cytologic–histologic pairs (a discordant rate of 8%). The majority (272; 75%) were sampling errors, with fewer interpretive errors (92; 25%). Sampling errors were found to occur most commonly in lower urinary tract and lung. Interpretive errors were most commonly found in lower urinary tract and thyroid.ConclusionsNongynecologic CHC data can be a valuable resource for cytology laboratories. By studying the types of errors, quality improvement activities can be targeted toward problem areas.
Patterns of genetic variation and morphology support the recognition of five species in the Gaultheria leucocarpa Blume (Ericaceae) group from mainland China
Authors: Li Yi‐Rong , Xu Yan‐Ling , Fritsch Peter W. , Lu Lu 
Published: June 2023

AbstractGaultheria leucocarpa and its varieties form a clade of aromatic shrubs that is widely distributed in subtropical and East Asian tropical regions. The group is taxonomically difficult and in need of thorough taxonomic investigation. This study focused on taxonomic delimitation within the G. leucocarpa group from mainland China. Field surveys covering the distributional range of G. leucocarpa in mainland China were conducted, wherein four populations from Yunnan and one from Hunan were found bearing morphological and habitat differences. A 63‐species phylogenetic tree of Gaultheria based on one nuclear and three chloroplast markers that included samples from the G. leucocarpa group was reconstructed with maximum likelihood to clarify the monophyly of the G. leucocarpa group. Taxonomic relationships among populations were investigated with morphology and population genetics, the latter by using two chloroplast genes and two low‐copy nuclear genes. Based on the sum of morphological and genetic analyses, we described three species of Gaultheria as new to science, clarified the taxonomic status of G. leucocarpa var. pingbienensis, elevating it to the species level, and resurrected G. crenulata and treated the varieties G. leucocarpa var. crenulata, and G. leucocarpa var. yunnanensis as synonyms of this species. We provide a key to the five species now recognized, along with descriptions and photographs.
Climate heterogeneity shapes phylogeographic pattern of Hippophae gyantsensis (Elaeagnaceae) in the east Himalaya‐Hengduan Mountains
Authors: Xu Ting , Wang Ruixue , La Qiong , Yonezawa Takahiro , Huang Xinyi , Sun Kun , Song Zhiping , Wang Yuguo , Bartish Igor V. , Zhang Wenju , Cheng Shanmei 
Published: June 2023

AbstractThe interaction of recent orographic uplift and climate heterogeneity acted as a key role in the East Himalaya‐Hengduan Mountains (EHHM) has been reported in many studies. However, how exactly the interaction promotes clade diversification remains poorly understood. In this study, we both used the chloroplast trnT‐trnF region and 11 nuclear microsatellite loci to investigate the phylogeographic structure and population dynamics of Hippophae gyantsensis and estimate what role geological barriers or ecological factors play in the spatial genetic structure. The results showed that this species had a strong east–west phylogeographic structure, with several mixed populations identified from microsatellite data in central location. The intraspecies divergence time was estimated to be about 3.59 Ma, corresponding well with the recent uplift of the Tibetan Plateau. Between the two lineages, there was significant climatic differentiation without geographic barriers. High consistency between lineage divergence, climatic heterogeneity, and Qingzang Movement demonstrated that climatic heterogeneity but not geographic isolation drives the divergence of H. gyantsensis, and the recent regional uplift of the QTP, as the Himalayas, creates heterogeneous climates by affecting the flow of the Indian monsoon. The east group of H. gyantsensis experienced population expansion c. 0.12 Ma, closely associated with the last interglacial interval. Subsequently, a genetic admixture event between east and west groups happened at 26.90 ka, a period corresponding to the warm inter‐glaciation again. These findings highlight the importance of the Quaternary climatic fluctuations in the recent evolutionary history of H. gyantsensis. Our study will improve the understanding of the history and mechanisms of biodiversity accumulation in the EHHM region.
Copepods' true colors: astaxanthin pigmentation as an indicator of fitness
Authors: Vilgrain Laure , Maps Frédéric , Basedow Sünnje , Trudnowska Emilia , Madoui Mohammed‐Amin , Niehoff Barbara , Ayata Sakina‐Dorothée 
Published: June 2023

AbstractPigmentation is often overlooked in zooplankton, since these organisms are mostly colorless to fit the translucid water medium. However, one of the dominant zooplankton taxa in aquatic ecosystems—copepods—often show a bright red‐orange or blue coloration owing to the accumulation of carotenoid pigments in some parts of their bodies. Even though there are many functional traits describing copepod's performance (e.g., size, feeding, and reproductive modes), it is surprising that the role of such a simple and visible trait as coloration has not been studied in a coherent manner yet. Here, by reviewing 95 studies, we demonstrate that carotenoid‐based pigmentation (mainly caused by astaxanthin molecules) is a widespread functional trait in freshwater and marine copepods. We propose a way to disentangle the complex and thus intriguing patterns of pigment expression along latitudinal and altitudinal gradients, addressing its relationship to diet quality and quantity, temperature, ultraviolet radiation stress, predation pressure, lipid metabolism, and reproduction. We show that large‐scale variations in pigmentation are difficult to tackle because of the fundamental plasticity of this trait at short time scales (i.e., hours, days), and the most recent information about carotenoid bioconversion are addressed (genes and enzyme identification, and influence of microbiota). From this literature review, we hypothesize that pigments play a “Swiss‐army knife” role for copepod's fitness, useful in various ecosystem conditions owing to the strong antioxidant power and the finely‐tuned metabolism of astaxanthin. With larger antioxidant capacities (survival), higher metabolisms (growth), and more offspring in better condition (reproduction), red morphs appear more successful than their uncolored siblings. Also, the potential camouflage strategies allowed by red and blue pigmentation are discussed. We finally formulate new directions and future research fields from molecular to ecosystem scales. Routine quantifications of copepod's pigmentation through trait‐based approaches could be useful (1) to obtain an accurate copepod fitness indicator and (2) to better estimate the transfer of antioxidant to higher trophic levels in ecosystems, including humans.
Epilepsy with eyelid myoclonia in the setting of de novo pathogenic variant in ATP1A3
Authors: Parfyonov Maksim , Ivaniuk Alina , Parikh Sumit , Pestana‐Knight Elia 
Published: June 2023

AbstractMutations in the ATP1A3 gene have been associated with several syndromes, including rapid‐onset dystonia‐parkinsonism, alternating hemiplegia of childhood, and cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss. In this clinical commentary, we report a 2‐year‐old female patient with de novo pathogenic variant in the ATP1A3 gene associated with an early‐onset form of epilepsy with eyelid myoclonia. The patient had frequent eyelid myoclonia occurring 20–30 times per day, without loss of awareness or other motor manifestations. EEG showed generalized polyspikes and spike‐and‐wave complexes maximal in the bifrontal regions, with prominent eye closure sensitivity. A sequencing‐based epilepsy gene panel revealed a de novo pathogenic heterozygous variant in ATP1A3. The patient showed some response to flunarizine and clonazepam. This case highlights the importance of considering ATP1A3 mutations in the differential diagnosis of early‐onset epilepsy with eyelid myoclonia and the potential benefit of flunarizine in improving language and coordination development in patients with ATP1A3‐related disorders.
Parabolic dune distribution, morphology and activity during the last 20 000 years: A global overview
Authors: Vimpere Lucas 
Published: June 2023

AbstractParabolic dunes form and migrate in almost every climate and geographic zones of the world, ranging from the tropical coastlines to the arid continental deserts. Despite their extensive distribution and their importance within the aeolian sediment landscape, the understanding of their morphological development, activity and link with climates remains somewhat limited to local or regional scales. A good understanding of the present climate conditions under which parabolic dunes are formed and/or reactivated would be significantly helpful to constrain past climate models. Similarly, an improved knowledge of parabolic dunes behaviour during past climatic episodes would provide some valuable long‐term data to better predict their future activity. This review first aims at providing a non‐exhaustive global database on parabolic dune morphology and the present wind regimes with which they are associated. To do so, the morphology of 750 dunes distributed worldwide was first analysed using a high‐resolution global digital elevation model, suggesting an intrinsic relationship between the different measured morphoparameters. The analysis of the associated local wind regimes shows that parabolic dunes develop under strong unidirectional winds, which are more conspicuous in coastal than continental environments. Dunes of different ages are globally aligned with present prevailing winds, which suggests a prevalent control of long‐term global atmospheric circulation on dune orientations. Finally, this study explores the link between parabolic dune activity and climates over the past 20 000 years by reviewing ages from the literature and combining them with the ones compiled in the INQUA Dunes Atlas Chronologic Database. Overall, it appears that changes towards drier conditions have triggered dunes migration during both warm and cold periods of the Last Glacial Maximum, Holocene Climate Optimum, Roman Climate Optimum, Medieval Climate Optimum and Little Ice Age. The present day aeolian activity is predominantly linked with deteriorating environmental conditions caused by human disturbances.
Effects of ultrasound combined with mild heat and potassium sorbate on Pichia membranaefaciens and the quality of soy sauce
Authors: Qian Jingya , Zhao Feng , Zhang Zixuan , Huo Shuhao , Ma Haile 
Published: June 2023

AbstractThe aim of this study was to investigate the effects of ultrasound (US) combined with mild heat (T) and potassium sorbate (PS) on Pichia membranaefaciens in soy sauce and the quality of soy sauce. The maximum reduction of P. membranaefaciens was 5.34 ± 0.15 log after thermoultrasound (TS, 300 W, 10/3 s, 20 + 40 kHz, 60°C) + PS (0.1 mg/mL) treatment for 20 min. Physicochemical properties, including pH and total acid of soy sauce, did not change significantly after TS + PS treatment. Electronic nose analysis showed changes in the flavour of soy sauce after different treatments. A total of 122 and 125 volatile compounds were detected by SPME‐GCMS before and after TS + PS treatment respectively. T90 (soy sauce processed at 90°C) treatment decreased the content of the flavour compounds greatly, while TS + PS decreased the content of the flavour compounds slightly in soy sauce. TS + PS treatment inactivated P. membranaefaciens effectively in soy sauce and maintained and partially improved the sensory and flavour characteristics of soy sauce, which indicates that this combination technology has potential application in the commercial processing of soy sauce.