bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of donor‐derived Strongyloides stercoralis infection in multiple solid organ transplant recipients—California, Michigan, Ohio, 2022
Authors: Adeyemo AdeSubomi , Montgomery Susan , Chancey Rebecca J. , Annambhotla Pallavi , Barba Lilly , Clarke Tyan , Williams Jonathan , Malilay Anne , Coyle Joseph 
Published: April 2023

AbstractBackgroundThe Centers for Disease Control and Prevention led an investigation to determine if Strongyloides infection in a right kidney recipient was an existing chronic infection, or if the infection was transmitted from an infected organ donor.MethodsEvidence regarding the organ donor and organ recipients Strongyloides testing, treatment, and risk factors were gathered and evaluated. The case classification algorithm created by the Disease Transmission Advisory Committee was utilized.ResultsThe organ donor had risk factors for Strongyloides infection; the banked donor specimen, submitted for serology testing 112 days post‐donor death, was positive. The right kidney recipient was negative for Strongyloides infection pretransplant. Strongyloides infection was diagnosed via small bowel and stomach biopsies. The left kidney recipient had risk factors for Strongyloides infection. Two posttransplant Strongyloides antibody tests were negative at 59 and 116 days posttransplant; repeat antibody tests returned positive at 158 and 190 days posttransplant.Examination of bronchial alveolar lavage fluid collected 110 days posttransplant from the heart recipient showed a parasite morphologically consistent with Strongyloides species. She subsequently developed complications from Strongyloides infection, including hyperinfection syndrome and disseminated strongyloidiasis. Based on the evidence from our investigation, donor‐derived strongyloidiasis was suspected in one recipient and proven in two recipients.ConclusionThe results of this investigation support the importance of preventing donor‐derived Strongyloides infections by laboratory‐based serology testing of solid organ donors. Donor positive testing results would direct the monitoring and treatment of recipients to avoid severe complications.
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The ALOG family members OsG1L1 and OsG1L2 regulate inflorescence branching in rice
Authors: Beretta Veronica M. , Franchini Emanuela , Ud Din Israr , Lacchini Elia , Van den Broeck Lisa , Sozzani Rosangela , Orozco‐Arroyo Gregorio , Caporali Elisabetta , Adam Hélène , Jouannic Stefan , Gregis Veronica , Kater Martin M. 
Published: April 2023

SUMMARYThe architecture of the rice inflorescence is an important determinant of crop yield. The length of the inflorescence and the number of branches are among the key factors determining the number of spikelets, and thus grains, that a plant will develop. In particular, the timing of the identity transition from indeterminate branch meristem to determinate spikelet meristem governs the complexity of the inflorescence. In this context, the ALOG gene TAWAWA1 (TAW1) has been shown to delay the transition to determinate spikelet development in Oryza sativa (rice). Recently, by combining precise laser microdissection of inflorescence meristems with RNA‐seq, we observed that two ALOG genes, OsG1‐like 1 (OsG1L1) and OsG1L2, have expression profiles similar to that of TAW1. Here, we report that osg1l1 and osg1l2 loss‐of‐function CRISPR mutants have similar phenotypes to the phenotype of the previously published taw1 mutant, suggesting that these genes might act on related pathways during inflorescence development. Transcriptome analysis of the osg1l2 mutant suggested interactions of OsG1L2 with other known inflorescence architecture regulators and the data sets were used for the construction of a gene regulatory network (GRN), proposing interactions among genes potentially involved in controlling inflorescence development in rice. In this GRN, we selected the homeodomain‐leucine zipper transcription factor encoding the gene OsHOX14 for further characterization. The spatiotemporal expression profiling and phenotypical analysis of CRISPR loss‐of‐function mutants of OsHOX14 suggests that the proposed GRN indeed serves as a valuable resource for the identification of new proteins involved in rice inflorescence development.
Proceedings of the 2022 NHLBI and OASH state of the science in transfusion medicine symposium
Authors: Custer Brian , Bloch Evan M. , Bryant Barbara J. , D'Alessandro Angelo , Delaney Meghan , Goel Ruchika , Hod Eldad A. , Josephson Cassandra D. , Katz Louis M. , Miller Yvette M. , Sayers Merlyn H. , Seheult Jansen N. , Triulzi Darrell J. , Berger James , Zou Shimian , Hailu Benyam , Glynn Simone A. , Roubinian Nareg H. 
Published: April 2023

AbstractBackgroundState of the Science (SoS) meetings are used to define and highlight important unanswered scientific questions. The National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, and the Office of the Assistant Secretary for Health (OASH), Department of Health and Human Services held a virtual SoS in transfusion medicine (TM) symposium.Study Design and MethodsIn advance of the symposium, six multidisciplinary working groups (WG) convened to define research priorities in the areas of: blood donors and the supply, optimizing transfusion outcomes for recipients, emerging infections, mechanistic aspects of components and transfusion, new computational methods in transfusion science, and impact of health disparities on donors and recipients. The overall objective was to identify key basic, translational, and clinical research questions that will help to increase and diversify the volunteer donor pool, ensure safe and effective transfusion strategies for recipients, and identify which blood products from which donors best meet the clinical needs of specific recipient populations.ResultsOn August 29–30, 2022, over 400 researchers, clinicians, industry experts, government officials, community members, and patient advocates discussed the research priorities presented by each WG. Dialogue focused on the five highest priority research areas identified by each WG and included the rationale, proposed methodological approaches, feasibility, and barriers for success.DiscussionThis report summarizes the key ideas and research priorities identified during the NHLBI/OASH SoS in TM symposium. The report highlights major gaps in our current knowledge and provides a road map for TM research.
Clinical efficacy of recombinant canine interferon‐gamma therapy in dogs with cutaneous epitheliotropic T‐cell lymphoma
Authors: Hoshino Tomoya , Murayama Nobuo , Yamagishi Kentaro , Okado Yoshitoshi , Iwai Haruaki , Shirai Ken , Hosaka Soshi , Moore Peter F. , Nagata Masahiko 
Published: April 2023

AbstractBackgroundThe antitumour effects of interferon‐gamma (IFN‐γ) in humans with cutaneous epitheliotropic T‐cell lymphoma (CETCL) have been described; however, the efficacy of IFN‐γ in dogs has not been investigated.Hypothesis/ObjectivesThe aim of this study was to evaluate the efficacy of recombinant canine IFN‐γ (rCaIFN‐γ) therapy in dogs with CETCL.AnimalsTwenty dogs with CETCL recruited from seven veterinary clinics were enrolled in the study.Materials and MethodsFifteen dogs were treated with rCaIFN‐γ, and five control dogs were treated with prednisolone. We evaluated survival time, skin lesions (erythema, nodules, ulcers and bleeding), pruritus and general condition (sleep, appetite and body weight). In the rCaIFN‐γ group, a questionnaire regarding the therapy was administered to owners after the dogs died.ResultsNo significant differences existed in the median survival time between the rCaIFN‐γ and control groups (log‐rank test:p = 0.2761, Wilcoxon's rank sum test: p = 0.4444). However, there were significant differences in ulcer, bleeding, pruritus, sleep, appetite and body weight between the groups (Wilcoxon–Mann–Whitney U‐test:p = 0.0023,p = 0.0058,p = 0.0005,p = 0.0191,p = 0.0306 andp = 0.0306, respectively). Two (40%) of five dogs were euthanised in the control group, compared with none in the rCaIFN‐γ group. Fourteen questionnaires were collected, and owners reported that they were satisfied with the rCaIFN‐γ treatment.Conclusions and Clinical RelevanceAlthough the median survival time was not prolonged, rCaIFN‐γ could be helpful in maintaining good quality of life for dogs with CETCL.
A repeatable CT protocol for quantifying caudal vena cava growth in medium and large breed dogs
Authors: Reeves Hannah C , Ryan Stewart D , Firestone Simon M , Milne Marjorie 
Published: April 2023

AbstractDevelopmental malformations can cause stunted or abnormal growth and clinical disease in dogs. In humans, measurements of the inferior vena cava are used as methods for detecting abnormal growth trajectories. The objectives of this retrospective, multicenter, analytical, cross‐sectional study were to develop a repeatable protocol to measure the caudal vena cava (CVC) and generate growth curves in medium and large‐breed dogs during development. Contrast‐enhanced CT DICOM images from 438 normal dogs, aged from 1 to 18 months, from five specific breeds were included. A “best guess” measurement protocol was created. Dogs were stratified into medium or large breed groups based on growth rate trajectories. Linear regression models and logarithmic trend lines were used to evaluate the CVC growth over time. The CVC measurements were analyzed from four anatomical regions: thorax, diaphragm, intra‐hepatic, and renal. The thoracic segment produced the most repeatable measurements with the highest explanatory power. The CVC thoracic circumference ranged from 2.5 to 4.9 cm from 1 to 18 months of age. Medium and large breeds had similar CVC growth trajectories, with comparable estimated marginal means, however medium dogs reached 80% of predicted final CVC size approximately 4 weeks earlier than large breed dogs. This new protocol provides a standardized technique for evaluation of the CVC circumference over time using contrast‐enhanced CT and is most repeatable when taken at the thoracic level. This approach could be adapted for other vessels to predict their growth trajectories, generating healthy reference population data for comparison against patients with vascular anomalies.
“THE GOD WITH CLAY”: THE IDEA OF DEEP INCARNATION AND THE INFORMATIONAL UNIVERSE
Authors: Gregersen Niels Henrik 
Published: April 2023

AbstractThis article explores the relations between the idea of deep incarnation and scientific ideas of an informational universe, in which mass, energy, and information belong together. It is argued that the cosmic Christologies developed in the vein of Cappadocian theology (fourth century) and the Franciscan theologian Bonaventure (thirteenth century) can be interpreted as precursors of an informational worldview by consistently blending “formative” and “material” aspects of creativity. Reversely, contemporary sciences of information can enlarge the scope of the contemporary view of deep incarnation. I propose three hypotheses for showing how and why. First, mass, energy, and information have an equal causal importance for explaining reality. Second, just as transformation presupposes communication, so communication presupposes information. Third, contemporary science can elucidate seminal concerns of the idea of deep incarnation, insofar as informational structures pave the way for information capture, communication, and transformation. At the level of organismic life, new features of embodied cognition and emotion come up, important for understanding the organismic depth of the concrete incarnation in Jesus of Nazareth.
Oil Seep Detection Using Microwave Remote Sensing at Espírito Santo Basin, Eastern Brazil
Authors: Espirito Santo Lucas Dos Anjos Correa do , Salomão Marcelo Dos Santos , Pedroso Enrico Campos , Appi Ciro Jorge 
Published: April 2023

Hydrocarbon seepage phenomena can be found in most petroleum provinces located in both coastal and ocean regions. The present work aims to identify, map and quantify oil seep candidates in the maritime portion of the Espírito Santo Sedimentary Basin using Synthetic Aperture Radar imagery from Radarsat-2 and Sentinel-1. The selection of the SAR images was made based on their basin coverage area. Meteorological and oceanographic data, when available, were used to assist interpretation. Later, the presence of structures that may enable fluids to escape (faults, fractures, salt domes, etc.) was verified in 101 seismic lines. After detailed analysis, the obtained data were gathered, aiming to classify the oil seep candidates found according to their probability of happening. There were 3 parameters, subdivided into criteria, used in the ranking score: SAR (distance of vessels, number nearby possible seeps and feature size), Geological (morphotectonic domains) and Seismic (distance from seismic lines, presence of structures and distance from structure). Each criterion received grades ranging from 0.1 to 1.0. The final score is given by the arithmetic mean of the parameters. This allowed the seep candidates to be organized in a ranking. The methodology was successful in identifying 54 promising features in the Espírito Santo basin and northern Campos basin. Half of the seep candidates found, 27 features, obtained a grade higher than 0.7, which strengthens the idea of being oil seeps. As an outcome a map was made in 1:3,500,000 scale with the location of all oil seep candidates mapped in this petroleum province.
Shared decision-making for children with medical complexity in community health services: a scoping review
Authors: Jacobs Sonja , Davies Nathan , Butterick Katherine L , Oswell Jane L , Siapka Konstantina , Smith Christina H 
Published: April 2023

BackgroundChildren with medical complexity is an increasing population whose parents and healthcare providers face multiple decisions. Shared decision-making is a process where patients, their families and healthcare providers collaborate to make decisions based on clinical evidence and informed preferences of the family. Shared decision-making has benefits for the child, family and healthcare providers, including improved parental understanding of the child’s difficulties, increased participation, improved coping skills and more efficient healthcare use. It is, however, poorly implemented.Aims and methodsA scoping review was conducted to explore shared decision-making for children with medical complexity in community health services, including how shared decision-making is defined in research, how it is implemented, including barriers and facilitators and recommendations for research. Six databases were systematically searched for papers published in English up to May 2022: Medline, CINAHL, EMBASE, PsycINFO, PubMed, Cochrane Database of Systematic Reviews and sources of grey literature. The review is reported according to the Preferred Reporting Items for Scoping Reviews.ResultsThirty sources met the inclusion criteria. Most factors can either be a facilitator or barrier to shared decision-making depending on the context. Two significant barriers to shared decision-making in this population include uncertainty about the child’s diagnosis, prognosis, and treatment options and the presence of hierarchy and power imbalance during clinical encounters with healthcare providers. Further influencing factors include continuity of care, the availability of accurate, accessible, adequate, and balanced information and the interpersonal and communication skills of parents and healthcare providers.ConclusionUncertainty about diagnosis, prognosis and treatment outcomes for children with medical complexity are additional challenges to the known barriers and facilitators to shared decision-making in community health services. Effective implementation of shared decision-making requires advancement of the evidence base for children with medical complexity, reducing power imbalance in clinical encounters, improving continuity of care, and improving the availability and accessibility of information resources.
Mutations inVWA8cause autosomal-dominant retinitis pigmentosa via aberrant mitophagy activation
Authors: Kong Linghui , Chu Guoming , Ma Wei , Liang Jiajian , Liu Dan , Liu Qiushi , Wei Xiaowei , Jia Shanshan , Gu Hui , He Yiwen , Luo Wenting , Cao Songying , Zhou Xiaomeng , He Rong , Yuan Zhengwei 
Published: April 2023

BackgroundAlthough retinitis pigmentosa (RP) is the most common type of hereditary retinal dystrophy, approximately 25%–45% of cases remain without a molecular diagnosis. von Willebrand factor A domain containing 8 (VWA8) encodes a mitochondrial matrix-targeted protein; its molecular function and pathogenic mechanism in RP remain unexplained.MethodsFamily members of patients with RP underwent ophthalmic examinations, and peripheral blood samples were collected for exome sequencing, ophthalmic targeted sequencing panel and Sanger sequencing. The importance ofVWA8in retinal development was demonstrated by a zebrafish knockdown model and cellular and molecular analysis.ResultsThis study recruited a Chinese family of 24 individuals with autosomal-dominant RP and conducted detailed ophthalmic examinations. Exome sequencing analysis of six patients revealed heterozygous variants inVWA8, namely, the missense variant c.3070G>A (p.Gly1024Arg) and nonsense c.4558C>T (p.Arg1520Ter). Furthermore,VWA8expression was significantly decreased both at the mRNA and protein levels. The phenotypes of zebrafish withVWA8knockdown are similar to those of clinical individuals harbouringVWA8variants. Moreover,VWA8defects led to severe mitochondrial damage, resulting in excessive mitophagy and the activation of apoptosis.ConclusionsVWA8plays a significant role in retinal development and visual function. This finding may provide new insights into RP pathogenesis and potential genes for molecular diagnosis and targeted therapy.
Capacity of piles subject to downdrag: a comparison of North American bridge design codes and observations from a full-scale test pile program
Authors: Bartz James R. , Blatz James A. 
Published: April 2023

Negative skin friction caused by ground settlement is an important consideration for deep foundations in limit states design. However, there are inconsistencies in the methodology whereby negative skin friction and associated drag force are considered in assessing the geotechnical capacity or geotechnical ultimate limit state (ULS) in various design codes. This includes two current North American bridge design codes, the Canadian Highway Bridge Design Code, and AASHTO LRFD Bridge Design Specifications. A test pile program was developed to observe effects of ground settlement on pile settlement, capacity, and drag force. Two instrumented steel H-piles were driven through a compressible clay layer to a hard end-bearing stratum, subjected to ground settlement by constructing a 1.5 m high embankment, followed by static load testing. A load-transfer model was calibrated from the test pile program observations. Test results and the calibrated model were used to compare geotechnical ULS requirements of the two bridge design codes. It is demonstrated that drag force did not detrimentally impact pile capacity. The results showed that for conditions of the test pile program, assessing the geotechnical ULS can be more conservative when adhering to the current AASHTO LRFD Bridge Design Specifications than the Canadian Highway Bridge Design Code.
Greedy Spanners in Euclidean Spaces Admit Sublinear Separators
Authors: Le Hung , Than Cuong 
Published: April 2023

The greedy spanner in a low-dimensional Euclidean space is a fundamental geometric construction that has been extensively studied over three decades, as it possesses the two most basic properties of a good spanner: constant maximum degree and constant lightness. Recently, Eppstein and Khodabandeh [
28
] showed that the greedy spanner in

\(\mathbb {R}^2\)

admits a sublinear separator in a strong sense: Any subgraph of
k
vertices of the greedy spanner in

\(\mathbb {R}^2\)

has a separator of size

\(O(\sqrt {k})\)

. Their technique is inherently planar and is not extensible to higher dimensions. They left showing the existence of a small separator for the greedy spanner in

\(\mathbb {R}^d\)

for any constant
d
≥ 3 as an open problem.

In this article, we resolve the problem of Eppstein and Khodabandeh [
28
] by showing that any subgraph of
k
vertices of the greedy spanner in

\(\mathbb {R}^d\)

has a separator of size

\(O(k^{1-1/d})\)

. We introduce a new technique that gives a simple criterion for any geometric graph to have a sublinear separator that we dub
τ-lanky
: A geometric graph is τ-lanky if any ball of radius
r
cuts at most τ edges of length at least
r
in the graph. We show that any τ-lanky geometric graph of
n
vertices in

\(\mathbb {R}^d\)

has a separator of size

\(O(\tau n^{1-1/d})\)

. We then derive our main result by showing that the greedy spanner is
O
(1)-lanky. We indeed obtain a more general result that applies to unit ball graphs and point sets of low fractal dimensions in

\(\mathbb {R}^d\)

.

Our technique naturally extends to doubling metrics. We use the τ-lanky criterion to show that there exists a (1+ε)-spanner for doubling metrics of dimension
d
with a constant maximum degree and a separator of size

\(O(n^{1-\frac{1}{d}})\)

; this result resolves an open problem posed by Abam and Har-Peled [
1
] a decade ago. We then introduce another simple criterion for a graph in doubling metrics of dimension
d
to have a sublinear separator. We use the new criterion to show that the greedy spanner of an
n
-point metric space of doubling dimension
d
has a separator of size

\(O((n^{1-\frac{1}{d}}) + \log \Delta)\)

where Δ is the spread of the metric; the factor log (Δ) is tightly connected to the fact that, unlike its Euclidean counterpart, the greedy spanner in doubling metrics has
unbounded maximum degree
. Finally, we discuss algorithmic implications of our results.
Visão de mundo e projeto de busca espiritual: o ethos de praticantes do yoga e Vedanta
Authors: Bastos Cecilia Guimarães 
Published: April 2023

Descrevo neste artigo o ethos de brasileiros que estudam Vedanta na Índia. Para compreender suas experiências, investigo a cosmovisão vedantina, cujas práticas, especialmente as de meditação e yoga, são recorrentes e acompanham o estudo de textos sagrados hindus, sendo então incorporadas a seus estilos de vida. Minha análise baseia-se na articulação entre a realização de estudos na Índia e as significativas transformações que ocorrem não apenas em seus estilos de vida, mas em suas visões de mundo. O objetivo é destacar a existência e o significado de algumas dessas transformações, que chegam a causar uma “mudança de paradigmas” (uma categoria “nativa”) – algo tão intenso que pode os levar a reavaliar seus mais profundos sentimentos. Examino então essas transformações como consequência de seus projetos de busca espiritual.
Dor em afecções reumatológicas
Authors: Romano Miriam Aparecida , Teixeira Manoel Jacobsen , Oliveira Priscila Rosalba de 
Published: April 2023

Dores músculo-esqueléticas são comuns. Os autores apresentam descrições simples e objetivos das mais prevalentes condições reumatológicas associadas à dor. Destacam a importância epidemiológica das osteoartroses, artrites e das condições periarticulares.
Fisiopatologia da dor músculo-esquelética
Authors: Teixeira Manoel Jacobsen , Yeng Lin Tchia , Kaziyama Helena Hideko Seguchi , Ramos Carolina Anunciação 
Published: April 2023

Dor decorrente das afecções músculo-esqueléticas é muito freqüente em todas as faixas etárias. Músculos, fásciasmusculares, articulações, ligamentos, tendões, periósteo, bursas sinoviais e enteses são ricamente inervados, o que justifica a ocorrência de dor quando sofrem lesões traumáticas, inflamatórias, isquêmicas, tumorais e ou sobrecargas funcionais. Mecanismos centrais e periféricos estão envolvidos na gênese e manutenção dos mecanismos dolorosos. Entre as várias condições clínicas a síndromedolorosa miofascial é uma das mais relevantes. Várias teorias foram propostas para justificá-la, todas enfatizando o papel dos estressores físicos e ou emocionais na geração da condição. O conhecimento da fisiopatologia da dor músculo-esquelética é importante para o diagnóstico e terapêutica dessas afecções.