bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medical Residents’ Informal Learning from Pharmacists in the Clinical Workplace
Authors: Floren Leslie Carstensen , Pittenger Amy L. , Wilting Ingeborg , Irby David M. , Cate Olle ten 
Published: May 2023

AbstractWorkplace-based interactions between residents and pharmacists, though relatively underexplored, might contribute substantially to learning. This international study sought to investigate the affordances residents use for informal learning about medications, their interactions with pharmacists and patterns of resident-pharmacist engagement, as well as residents’ perceived impact of these interactions on their learning. Contextual differences between US and Dutch residency training and electronic health record (EHR) may impact informal learning about medications. We conducted a cross-sectional, online, 25-item survey study, including closed-format and open-response questions among current resident physicians (post-graduate years 1–6, from a variety of residency programs n = 803) from the University of California San Francisco, the University of Minnesota, and the University Medical Center Utrecht. Responses from 173 residents in both countries revealed that these physician trainees were afforded opportunities to engage in a wide variety of pharmacotherapy-related activities but engaged differently with social and environmental resources for support. Residents from the United States (US) utilized pharmacists and Up-To-Date, whereas Dutch residents preferentially utilized the online Dutch medication information site and EHR-embedded medication resources. US residents interacted with pharmacists significantly more frequently than Dutch residents. Pharmacists provided residents with a wide range of useful information, much of which is integrated into the medication resources in the Dutch EHR-based decision-support system. While US residents reported overwhelmingly that informal interactions with pharmacists contribute to their learning about medications, Dutch residents’ responses did not confirm this. Intentionally designing residents’ training to include opportunities for interactions with pharmacists could potentially positively impact residents’ informal workplace learning.
Using Evidence-Based Learning Strategies to Improve Medical Education
Authors: Madan Christopher R. 
Published: May 2023

AbstractMedical education research has been adopting principles from psychology to improve student learning. Here is an overview and illustrative examples of six evidence-based learning strategies that have been thoroughly researched and validated in the psychology literature: spacing, interleaving, retrieval practice, elaboration, dual coding, and concrete examples. For each of these, their use within medical education and considerations that may influence efficacy are discussed. Medical education researchers should collaborate more with psychology researchers in transdisciplinary teams to better implement these strategies and more directly benefit from advances made in the psychology literature.
Salient object detection for RGBD video via spatial interaction and depth-based boundary refinement
Authors: Zhang Yujian , Zhang Ziyan , Zhang Ping , Xu Mengnan 
Published: May 2023

AbstractRecently proposed state-of-the-art saliency detection models rely heavily on labeled datasets and rarely focus on perfect RGBD feature fusion, which lowers their generalization ability. In this paper, we propose a depth-based interaction and refinement network (DIR-Net) to fully leverage the depth information provided with RGB images to generate and refine the corresponding saliency segmentation maps. In total, three modules are included in our framework. A depth-based refinement module (DRM) and an RGB module work in parallel while coordinating via interactive spatial guidance modules (ISGMs), which utilize spatial and channel attention computed from both depth features and RGB features. In each layer, the features in both modules are refined and guided by the spatial information obtained from the other module through ISGMs. In the RGB module, before sending the depth-guided feature map to the decoder, a convolutional gated recurrent unit (ConvGRU)-based block is introduced to handle temporal information. Thinking about the clear movement information in RGB features, the block also guides temporal information in DRM. By merging the results from both the DRM and RGB modules, a segmentation map with distinct boundaries is generated. Considering the lack of depth images in popular public datasets, we utilize a depth estimation network that incorporates manual postprocessing-based correction to generate depth images on the DAVIS and UVSD datasets. The state-of-the-art performance achieved on both the original and new datasets illustrates the advantage of our RGBD feature fusion strategy, with a real-time speed of 19 fps on a single GPU.
Effect of strain rate on mechanical response and failure characteristics of horizontal bedded coal under quasi-static loading
Authors: Liang Yunpei , Kong Fanjie , Zou Quanle , Zhang Bichuan 
Published: May 2023

AbstractStrain rock burst is one of the main types of rock bursts. Studying the mechanical response and acoustic emission characteristics of coal under quasi-static loading is significant to control and prevent strain rock bursts. In this paper, coal’s strength, deformation, energy evolution, and failure characteristics were analyzed with different strain rates under quasi-static loading. The strength characteristics of coal show a strain rate effect to a certain extent and the elastic modulus decreases first and then increases with stain rate increasing. Moreover, the elastic strain energy of coal samples always accounts for a high proportion before failure and the failure of coal presents a combined failure mode of tensile and shear under the dominance of tensile failure. The contribution of the shear failure to coal failure increases correspondingly when strain rate increases. Under quasi-static loading, There is a range where the strain rate effect does not appear, named as strain rate effect invisible area. The high static loading stress, and direct action of high strain rate loading should be avoided to reduce the risk of rock burst, especially for isolated coal pillars. The research achievements deepen the understanding of strain rock burst and provides critical support for the prevention of strain rock burst induced by high static loading.
Dynamic compressive failure of coal at different burial depths
Authors: Li Shengwei , Gao Mingzhong , Wu Bangbiao , Xu Ying , Li Yexue , Zeng Gang 
Published: May 2023

AbstractDynamic disasters frequently occur in deep coal mines, where coals and rocks are under high in situ stresses. To reveal the failure mechanism of deep burying coals, the specimens were made of buried coals at a depth of about 1 km. An improved Kolsky bar was applied to conduct the dynamic compression experiments subjected to different hydrostatic pressure i.e., 0, 5, 10, 15, and 20 MPa for simulating in situ stresses corresponding to depths of 0, 200, 400, 600, and 800 m. The findings demonstrate that the dynamic compressive strength of coal at a specified depth is rate-dependent. And the dynamic strength is positively correlated with the burial depth at a given loading rate. Moreover, a Mohr–Coulomb strength criterion for coal under dynamic loadings that considers the effect of depth is established, and the model describes the experimental results well.
Mixed mode I/II fracture behavior of CSTBD sandstone specimen under different loading angles
Authors: Cao Peiwang , Zhou Tao , Ju Yang , Zhu Jianbo 
Published: May 2023

AbstractCracks are often exposed to mixed mode I/II loading because of the random direction of crack relative to the external load, causing rock failure in rock engineering. However, many mixed mode I/II fracture properties of rock with different loading angles (β) are still poorly understood. To investigate the influence of β on mixed mode I/II fracture behavior, cracked straight through Brazilian disc tests were performed on sandstone under various β at the loading rate of 0.2 kN/s. The results show that the effect of β on the peak load and crack propagation velocity is slight. The mode I stress intensity factor (SIF) decreases from positive to negative with increasing β, while mode II SIF first increases and then decreases as β exceeds approximately 30°. The mixed mode I/II fracture toughness increases linearly with increasing β. When β exceeds 60°, the crack initiation location shifts from the center of the semi-circular notch tip to the surface of preset crack. For non-tip cracking, the crack propagates toward the loading point in a direction approximately perpendicular to the preset crack. The threshold β for it decreases with increasing internal friction coefficient and relative crack length. Moreover, the mixed-mode fracture surface becomes smoother as the mode I component contribution drops. There are remarkable differences in the prediction of fracture initiation angles and SIFs of various rock types applying the generalized maximum tangential stress criterion. The findings of this study could help understand the mixed mode I/II fracture observed in rock engineering.
Homeostasis and dyshomeostasis of the retina
Authors: Zhang Chang-Jun , Jin Zi-Bing 
Published: May 2023

AbstractRetinal homeostasis is maintained through a network of the nervous, circulatory, endocrine and immune systems. The integrity of the blood-retinal barrier, immune-inflammatory responses, and metabolic changes all significantly affect the maintenance of normal visual function. Retinal degenerative diseases, which include age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy, and other disorders, are a group of heterogeneous and multi-etiological diseases resulting in an irreversible visual impairment. Whether these disorders are inherited, acquired, or from systemic origins, the gradual loss of the retinal pigment epithelium (RPE) and/or retinal neurons is a common feat. This process often begins with compromised retinal integrity, followed by a disruption in the equilibrium of inflammation, immune response, metabolism, and other aspects, resulting in retinal dyshomeostasis that affects not only disease progression but also the effect of therapeutic intervention. Therefore, a comprehensive understanding of the retinal homeostasis and dyshomeostasis will assist the development of treatment strategies for retinal degenerative diseases and open new avenues for clinical translation.
Global Burden of Prostate Cancer and Association with Socioeconomic Status, 1990–2019: A Systematic Analysis from the Global Burden of Disease Study
Authors: Zhang Weiyu , Cao Guiying , Wu Feng , Wang Yuliang , Liu Zheng , Hu Hao , Xu Kexin 
Published: May 2023

Abstract
Importance
Both the morbidity and mortality of prostate cancer are increasing worldwide. Updated evaluations of prostate cancer burden and its global, regional and national patterns are essential for formulating effective preventive strategies.

Objective
To investigate prostate cancer incidence, mortality, and disability-adjusted life years (DALYs) between 1990 and 2019 to facilitate preventive measures and control planning.

Methods
Annual incident cases, deaths, DALYs, age-standardized incidence rates (ASIRs), age-standardized mortality rates (ASMRs), and age-standardized DALYs rates (ASDRs) of prostate cancer between 1990 and 2019 were derived from the Global Burden of Diseases study 2019. Percentage changes in incident cases, deaths and DALYs and estimated annual percentage changes (EAPCs) in ASIRs, ASMRs and ASDRs were calculated to quantify temporal trends. Correlations between EAPCs and socio-demographic index (SDI) and universal health coverage index (UHCI) were evaluated by Pearson correlation analyses.

Results
Globally, the number of incident cases, deaths, and DALYs of prostate cancer increased by 116.11%, 108.94%, and 98.25% from 1990 to 2019, respectively. The ASIR increased by an average of 0.26% (95% CI: 0.14%, 0.37%) per year between 1990 and 2019, while the ASMR and ASDR decreased by an average of – 0.75% (95% CI: – 0.84%, – 0.67%) and – 0.71% (95% CI: – 0.78%, – 0.63%) per year in this period, respectively. Epidemic trends in the burdens of prostate cancer were not uniform throughout different groups of SDI or geography. The burdens of prostate cancer varied across SDI regions, with an increasing trend in ASIR, ASMR, and ASDR in low and low-middle SDI regions between 1990 and 2019. A significant positive correlation between the EAPC in ASIR and UHCI was observed in countries with a UHCI < 70 (ρ = 0.37, p < 0.001).

Interpretation
Prostate cancer remains a major global health burden due to the increase in incident cases, deaths, and DALYs in the past three decades. These increases are likely to continue as the population ages, which indicates a potential talent gap in the trained healthcare workforce. The diversity of prostate cancer development models implies the importance of specific local strategies tailored for each country’s risk factor profile. Prevention, early detection and more effective treatment strategies for prostate cancer are essential.
Manual vs Mechanical Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest on a Ski Slope: A Pilot Study
Authors: Rupp Scott L. , Overberger Ryan C. 
Published: May 2023

Introduction The quality of cardiopulmonary resuscitation (CPR) is critical in increasing the probability of survival with a good neurologic outcome after out-of-hospital cardiac arrest. In an austere environment with a potentially salvageable patient, bystanders or first responders may need to provide chest compressions for a prolonged duration or during physically challenging transportation scenarios. Consequently, they may be at risk of fatigue or injury, and chest compression quality may deteriorate. The study sought to assess whether or not access to and utilization of a mechanical compression device (Lund University Cardiopulmonary Assist System) was feasible and not inferior to manual compressions while extricating and transporting a patient from a ski slope. Methods Variable 3-person ski patrol teams responded to a simulated patient with out-of-hospital cardiac arrest in a nonshockable rhythm. Using a mannequin and CPR quality monitor, performance during manual CPR was compared with that of a mechanical compression device. This is a prospective, crossover analysis of CPR quality during extrication from a ski slope. Across 8 total runs, chest compression fraction, which is the proportion of time without spontaneous circulation during which compressions occurred, and high-quality CPR, as measured by appropriate rate and depth, were compared between the 2 groups. Extrication times between the 2 groups were also measured. Results There was no difference in compression fraction between the manual (91.4%; 95% CI [86.8–96.1]) and mechanical arms (92.8%; 95% CI [88.8–96.8]) ( P=0.67). There was an increase in the time performing high-quality CPR in the mechanical group (58.5%; 95% CI [45.8–71.2]) vs that in the manual group (25.6%; 95% CI [13.5–37.8]) ( P<0.001). There was a statistically significant difference in the extrication times between the 2 groups, 7.6 ± 0.5 min in the manual group vs 8.6 ± 0.4 min in the mechanical group ( P=0.014). Conclusions Mechanical CPR devices are noninferior for use in ski areas during initial resuscitation and transportation. Compared with manual CPR, mechanical CPR would likely improve the fraction of time performing high-quality CPR.
A review of recent and future marine extinctions
Authors: del Monte-Luna Pablo , Nakamura Miguel , Vicente Alba , Pérez-Sosa Lilian B. , Yáñez-Arenas Arturo , Trites Andrew W. , Lluch-Cota Salvador E. 
Published: May 2023

AbstractBetween 20 and 24 marine extinctions, ranging from algal to mammal species, have occurred over the past 500 years. These relatively low numbers question whether the sixth mass extinction that is underway on land is also occurring in the ocean. There is, however, increasing evidence of worldwide losses of marine populations that may foretell a wave of oncoming marine extinctions. A review of current methods being used to determine the loss of biodiversity from the world’s oceans reveals the need to develop and apply new assessment methodologies that incorporate standardized metrics that allow comparisons to be made among different regions and taxonomic groups, and between current extinctions and past mass extinction events. Such efforts will contribute to a better understanding of extinction risk facing marine flora and fauna, as well as the ways in which it can be mitigated.
Influence of Changes in pH and Temperature on the Distribution of Apparent Iron Solubility in the Oceans
Authors: Zhu Kechen , Achterberg Eric P. , Bates Nicholas R. , Gerringa Loes J. A. , Middag Rob , Hopwood Mark J. , Gledhill Martha 
Published: May 2023

AbstractAn insufficient supply of the micronutrient iron (Fe) limits phytoplankton growth across large parts of the ocean. Ambient Fe speciation and solubility are largely dependent on seawater physico‐chemical properties. We calculated the apparent Fe solubility (SFe(III)app) at equilibrium for ambient conditions, where SFe(III)app is defined as the sum of aqueous inorganic Fe(III) species and Fe(III) bound to organic matter formed at a free Fe3+ concentration equal to the solubility of Fe hydroxide. We compared the SFe(III)app to measured dissolved Fe (dFe) in the Atlantic and Pacific Oceans. The SFe(III)app was overall ∼2–4‐fold higher than observed dFe at depths less than 1,000 m, ∼2‐fold higher than the dFe between 1,000 and 4,000 m and ∼3‐fold higher than dFe below 4,000 m. Within the range of used parameters, our results showed that there was a similar trend in the vertical distributions of horizontally averaged SFe(III)app and dFe. Our results suggest that vertical dFe distributions are underpinned by changes in SFe(III)app, which are driven by relative changes in ambient pH and temperature. Since both pH and temperature are essential parameters controlling ambient Fe speciation, these should be accounted for in investigations of changing Fe dynamics, particularly in the context of ocean acidification and warming.
Mesoscale Eddies Enhance the Air‐Sea CO2 Sink in the South Atlantic Ocean
Authors: Ford Daniel J. , Tilstone Gavin H. , Shutler Jamie D. , Kitidis Vassilis , Sheen Katy L. , Dall’Olmo Giorgio , Orselli Iole B. M. 
Published: May 2023

AbstractMesoscale eddies are abundant in the global oceans and known to affect oceanic and atmospheric conditions. Understanding their cumulative impact on the air‐sea carbon dioxide (CO2) flux may have significant implications for the ocean carbon sink. Observations and Lagrangian tracking were used to estimate the air‐sea CO2 flux of 67 long lived (>1 year) mesoscale eddies in the South Atlantic Ocean over a 16 year period. Both anticyclonic eddies originating from the Agulhas retroflection and cyclonic eddies originating from the Benguela upwelling act as net CO2 sinks over their lifetimes. Anticyclonic eddies displayed an exponential decrease in the net CO2 sink, whereas cyclonic eddies showed a linear increase. Combined, these eddies significantly enhanced the CO2 sink into the South Atlantic Ocean by 0.08 ± 0.04%. The studied eddies constitute a fraction of global eddies, and eddy activity is increasing; therefore, explicitly resolving eddies appears critical when assessing the ocean carbon sink.
Prediction of Axial Asymmetry in Jovian Magnetopause Reconnection
Authors: Chen Junjie , Zhang Binzheng , Lin Dong , Delamere Peter A. , Yao Zhonghua , Brambles Oliver , Sorathia Kareem A. , Merkin Viacheslav G. , Lyon John G. 
Published: May 2023

AbstractWe show the possible existence of a significant axial asymmetry in the reconnection separator at the Jovian magnetopause using first‐principle, physics‐based global simulations. Under eastward interplanetary magnetic field (IMF) conditions near Jupiter's orbit, reconnection occurs at the southern‐dusk and northern magnetopause with large shear angles between the magnetospheric and magnetosheath magnetic fields. When driven by the westward IMF, the reconnection position switches to the northern‐dusk and southern magnetopause. Component reconnection at the southern‐dusk/northern‐dusk magnetopause is associated with the interaction of the IMF with the nearly‐dipolar background fields. Nearly‐antiparallel reconnection near the noon‐midnight plane at the northern/southern magnetopause is related to the dawn‐dusk asymmetric, helical, closed lobe magnetic fields, which is a consequence of significant planetary corotation effects and not expected at Earth. Such configuration is testable as Juno has proceeded its orbit to the high‐altitude cusps and provides new insight into the interpretation of measurements from other rotationally‐driven systems.
How the Indian Ocean Geoid Low Was Formed
Authors: Pal Debanjan , Ghosh Attreyee 
Published: May 2023

AbstractThe origin of the Earth's lowest geoid, the Indian Ocean geoid low (IOGL) has been controversial. The geoid predicted from present‐day tomography models has shown that mid to upper mantle hot anomalies are integral in generating the IOGL. Here we assimilate plate reconstruction in global mantle convection models starting from 140 Ma and show that sinking Tethyan slabs perturbed the African Large Low Shear Velocity province and generated plumes beneath the Indian Ocean, which led to the formation of this negative geoid anomaly. We also show that this low can be reproduced by surrounding mantle density anomalies, without having them present directly beneath the geoid low. We tune the density and viscosity of thermochemical piles at core‐mantle boundary, Clapeyron slope and density jump at 660 km discontinuity, and the strength of slabs, to control the rise of plumes, which in turn determine the shape and amplitude of the geoid low.
Proton Flux Variations During Solar Energetic Particle Events, Minimum and Maximum Solar Activity, and Splitting of the Proton Belt in the South Atlantic Anomaly
Authors: Pierrard V. , Benck S. , Botek E. , Borisov S. , Winant A. 
Published: May 2023

AbstractThe analysis of the proton flux variations observed by the Energetic Particle Telescope (EPT) at energies >9.5 MeV from the launch of PROBA‐V satellite on 7 May 2013 up to October 2022 shows an anti‐correlation between the proton fluxes and the solar phase. At solar minimum, the fluxes are higher at low L corresponding to the northern border of the South Atlantic Anomaly (SAA). This solar cycle modulation of the inner belt is mainly due to losses by increased atmospheric interactions during solar maximum. Strong Solar Energetic Particle (SEP) events, like in January 2014, June 2015, and September 2017, inject energetic protons at high latitudes, but not in the inner belt where protons are trapped at long term at low L. Nevertheless, big geomagnetic storms, including those following SEP a few days after, can cause losses of protons at the outer border of the proton belt, due to magnetic field perturbations. A double peak in the proton belt is observed during long period of measurements only for the EPT channel of 9.5–13 MeV. The narrow gap between the two peaks in the inner belt is located around L = 2. This resembles to a splitting of the proton belt, separating the SAA into two different parts, North and South. The high‐resolution measurements of PROBA‐V/EPT allow the observation of small‐scale structures that brings new elements to the understanding of the different source and loss mechanisms acting on the proton radiation belt at LEO.