bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural Reconstruction Strategy Enables CoFe LDHs for High‐Capacity NH4+ Storage and Application in High‐Energy Density Ammonium‐Ion Hybrid Supercapacitors**
Authors: Wang Dewei , Sun Jiaqi , Chen Long 
Published: March 2023

AbstractExploration of high‐performance aqueous ammonium‐ions hybrid supercapacitor has attracted tremendous research attention recently. Herein, structural reconstructed cobalt‐iron layered double hydroxides (SR‐CoFe LDHs) featuring copious structure defects (i. e., oxygen‐vacancies, M−O bonds, MOO− bonds, coexistence of Co2+/Co3+ and Fe2+/Fe3+) are reported as a high‐capacity cathode for NH4+ storage. The resulting SR‐CoFe LDHs can deliver a reversible capacity of 167.9 mAh g−1 at 0.5 A g−1, which is 3.3 folds higher than that of pristine CoFe‐LDHs. Ex‐situ experimental results and theoretical studies denote that the presence of structural defects in the CoFe‐LDHs can lower the NH4+ adsorption energy and induced electron delocalization to enhance the electrical conductivity, rendering the CoFe‐LDHs exhibits excellent performance for NH4+ storage. As a proof of concept, ammonium‐ion hybrid supercapacitor has been assembled with CoFe‐LDHs as the cathode and hierarchical carbon as the anode, which can deliver a large specific capacitance of 238.3 F g−1, long cycle stability over 10000 cycles, and high energy density of 66.2 Wh kg−1 within a wide working voltage of 2 V. Overall, this work offers some insights into the design of high capacity cathode for aqueous NH4+ storage and also illustrates the construction of aqueous hybrid devices with NH4+ as the charge carrier.
Thieno[2,3‐c]isoquinolines: A novel chemotype of antiproliferative agents inducing cellular apoptosis while targeting the G2/M phase and Tubulin
Authors: Marae Islam S. , Maklad Raed M. , Samir Safia , Bakhite Etify A. , Sharmoukh Walid 
Published: March 2023

AbstractIn the era of modern synthetic methodology and advanced bio‐evaluation techniques and considering the notorious history of hepatocellular carcinoma (HCC), hopeful expectations regarding novel bioactive chemotypes have grown dramatically. Among the widely versatile motifs in drug discovery studies are isoquinoline and thieno[2,3‐b]pyridine. Herein, the molecular merging of both motifs evoked thieno[2,3‐c]isoquinoline as a novel antiproliferative chemotype being hardly studied against HCC. Accordingly, compound series 4, 5, 7 and 8 were synthesized and bioevaluated against the HepG2 cell line. The role of C7‐Ac/C8‐OH substituents, C8‐C9 unsaturation, 1H‐pyrrol‐1‐yl ring closure at C1‐NH2 and C6‐Ph p‐halo‐substitution were biologically studied and successfully furnished the lead 5b while showing safe profile against Vero cells. Further, flow cytometric and Annexin V‐FITC/PI apoptotic bio‐investigations of 5b unveiled remarkable cell cycle arrest at the G2/M phase besides a 60‐fold increase in apoptosis. The use of a DFT conformational study followed by Molecular docking and molecular mechanics/generalized born surface area scoring evoked potential tubulin‐targeting activity of 5b at colchicine‐binding site, which was confirmed by experimental evidence (Tub Inhib IC50 = 71 µM vs. 14 µM for colchicine). Accordingly, preserving C7‐acetyl and optimizing halogen position while preserving [6S,7R]‐stereochemistry is crucial for optimum binding to colchicine binding site of tubulin.
Critical operating parameters of solar flat plate collectors using CuO nanoparticles of different volume fractions subjected to natural convection
Authors: Devarajan Yuvarajan , Munuswamy Dineshbabu , Subbiah Ganesan , Mishra Ruby 
Published: March 2023

AbstractA flat plate solar water heater is investigated for its efficiency when water and the copper oxide (CuO) of 20 nm size nanoparticles of varying volume fractions and their performance are studied. A solar water heater with a flat plate collector of dimensions 1 × 0.45 m2 with 25 liter per day storage tank capacity, which works on the thermo‐syphon principle, is fabricated. The collector is run with a base working fluid of deionized water and then with CuO nanoparticles for different volume fractions of 0.2% and 0.4% with a surfactant to study the collector's efficiency. The surfactant used in cetyltrimethylammonium bromide of 1% in working fluid. The rise in temperature and the collector efficiency is compared for different volume fractions of CuO nanoparticles in the collector. The mixing of nanoparticles thus improves the efficiency of the collector. The experimental result shows that the collector with a 0.4% volume fraction of CuO with water as a working fluid has the maximum rise in temperature and efficiency compared with that of 0.2% and water. During the test, CuO without surfactant showed a slight decrement in heat transfer due to the agglomeration. The collector efficiency for 0.4% volume fraction achieves 63.28%, for 0.2% is 61.58%, and for water 54.15%. The overall efficiency was increased by up to 9.1% compared with base conventional fluid water for lower volume fractions of CuO nanoparticles for a smaller collector area.
Impact of myomectomy on the obstetric complications: A large cohort study in Japan
Authors: Komatsu Hiroaki , Taniguchi Fuminori , Harada Tasuku 
Published: March 2023

AbstractObjectiveThe authors conducted a large‐scale cohort study using the Japan Society of Obstetrics and Gynecology's perinatal registry database to determine the effect of myomectomy on perinatal outcomes.MethodsThis retrospective cohort study enrolled 203 745 women who gave birth between January and December 2020 in Japan. The participants were classified into two groups based on their history of myomectomy (open/laparoscopic) to investigate fertility treatment, delivery information, obstetric complications, maternal treatment, infant information, fetal appendages, obstetric history, underlying disease, infectious disease, drugs used, and case information regarding maternal and infant death.ResultsIn total, 1161 pregnant women had a history of myomectomy and 202 584 did not. Compared with the nonmyomectomy group, the myomectomy group had a higher occurrence rate of uterine rupture (0.9% vs 0.06%, P < 0.01) and placenta accreta (1.5% vs 0.5%, P < 0.01). In addition, history of myomectomy (odds ratio [OR], 2.62 [95% confidence interval (CI), 1.500–4.226]; P < 0.001) was found to be an independent factor for placenta accrete and uterine rupture (OR, 14.4 [95% CI, 6.75–27.02]; P < 0.001). Furthermore, myomectomy increased the risk of uterine rupture by 14 times.ConclusionPostmyomectomy pregnancy may increase the risk of placenta accreta and uterine rupture.
The ethics of infant and early childhood mental health practice
Authors: Lim Izaak , Korfmacher Jon , Steier Alison , Zeanah Charles , Zeanah Paula D. 
Published: March 2023

AbstractEthics is concerned with the basis for moral judgments of “right” and “wrong” and is central to the clinical endeavor. Many clinicians integrate ethical estimations into their work without much conscious awareness. However, explicit use of ethical principles and frameworks can help navigate clinical decision‐making when there is a sense of moral conflict or ambiguity about the “right” course of action. This article aims to highlight the key concepts and principles in clinical ethics as they apply to IECMH practice and stimulate a bigger conversation in the profession around how to support each other to maintain high ethical standards in working with young children and their families. Specifically, the authors consider the relevance of Beauchamp and Childress’ four principles framework (respect for autonomy, beneficence, non‐maleficence, and justice), and address some of the special ethical challenges in the field, namely, the vulnerability of the infant, the need for a competent workforce, caring for caregivers, and the problem of multiple patients. Finally, the role of infant rights is briefly explored, noting the significant interest and debate that has been generated by the publication of the World Association of Infant Mental Health'sPosition Paper on the Rights of Infants.
Determination of yield response factors for different varieties of teff
Authors: Asres Ligalem Agegn , Derebe Melkamu Ateka 
Published: March 2023

AbstractThe yield response factor (Ky) at different crop growth stages for different varieties of teff is important to identify the sensitivity stage to water stress for irrigation water management. However, Ky is affected by crop variety and agroclimatic conditions, but there has been no study for different varieties of teff. Therefore, this study focused on the determination of Ky for different varieties of teff. In total, 18 treatments were designed as randomized complete block design and replicated three times. Crop evapotranspiration was measured using a weighing‐type lysimeter. Yield response factors were determined as a function of yield and crop evapotranspiration at each crop growth stage of teff. Accordingly, the stagewise Ky for the Tseday teff variety was 0.32, 0.39, 0.55 and 0.06 and for the Quncho teff variety 0.19, 0.24, 0.56 and 0.03 for the vegetative, flowering, yield formation and ripening growth stages, respectively. The seasonal Ky values for Tseday and Quncho were 1.30 and 1.11, respectively. Therefore, water stress during the yield formation growth stage is not recommended, whereas it is possible to adopt irrigation water stress at the ripening growth stage to save water. The saved water will be used for the extension of irrigable agricultural areas.
Research and scholarly methods: Audit studies
Authors: Loera Lindsey J. , Hill Lucas G. , Evoy Kirk E. , Reveles Kelly R. 
Published: March 2023

AbstractAudit study methodologies have been utilized in pharmacy field research to obtain greater understanding of potential gaps in real‐world care and assess the accessibility of medications, services, and providers. Many audit studies utilize a secret‐shopper approach in which auditors follow specific assessment protocols and the subjects being audited are unaware of the audit taking place. The benefit of utilizing this approach, as compared to surveys or interviews, is that researchers are able to collect real‐world measures with minimized social desirability and recall biases. There are multiple audit study approaches investigators must consider. Additionally, successful audit studies often rely upon congruence of multiple auditors, and it is therefore essential to develop a study protocol that includes detailed guidance documents, data collection tools, and rigorous training and fidelity assessments. Audit methodologies must be conducted with meticulous auditor training and oversight, especially when investigators seek to audit a large sample and rely on auditors who may be participating on an unpaid volunteer basis. The purpose of this review is to provide an orientation to audit study methodologies and to describe best practices for conducting a successful audit study.
Overview of implementation and learning outcomes of simulation in pharmacy education
Authors: McBane Sarah , Alavandi Prasannaraddi , Allen Sheila , Bingham Angela , Dang Yen , Elmes Abigail , Fallon Julianne M. , Herman Alexandra , Januszka Jenna , Peddi Apryl N. , Posey L. Michael , Putney Kaylee , Richter Sara , Shrader Sarah , Thomas Michael , Seybert Amy 
Published: March 2023

AbstractSimulation, an educational, assessment, and research technique used to mimic real‐world situations, is increasingly used in pharmacy education. The most‐used simulation methods include high‐fidelity simulation (HFS), low‐fidelity simulation (LFS), standardized patients, and game‐based simulation. A common element of simulation is its ability to offer learners the chance to practice a skill or acquire knowledge in a safe and accessible space. Simulation methods differ in key aspects, including cost and other resource investment as well as ideal venue for use in education. HFS provides a more realistic simulation environment than LFS but is typically more expensive. Standardized patients offer learners the opportunity to engage with a live person but may elicit greater variability in responses to learners' input than HFS. Computer‐based simulation uses technology to supply a wide variety of learning opportunities; however, it may require the use of proprietary software and devices. Despite widespread use, literature describing learning outcomes of simulation in pharmacy education is limited. Some existing reports with positive findings have focused on learner satisfaction with or perceived benefit of simulation activities. The few existing publications summarizing changes in skills or knowledge demonstrate a positive impact. Simulation is a promising modality for educating pharmacy students and residents; however, more data summarizing the benefit of learning outcomes are needed.
Tropisetron restores normal expression of BAD, SIRT1, SIRT3, and SIRT7 in the rat pressure overload‐induced cardiac hypertrophy model
Authors: Karimollah Alireza , Hemmatpur Anahid , Safari Fatemeh , Fakhrgholami Mahsa , Travat Tina 
Published: March 2023

AbstractTropisetron exerts a protective effect against cardiac complications, particularly cardiac hypertrophy. Oxidative stress and apoptosis are the main contributors to the pathogenesis of cardiac hypertrophy. Sirtuins, a family of histone deacetylases, are connected to cellular oxidative stress signaling and antioxidant defense. Sirtuins are also linked to apoptosis which is an important mechanism in the progression of cardiac hypertrophy to heart failure. Literature also suggests that tropisetron impedes apoptosis, partly mediated through an antioxidant mechanism. Therefore, we examined if tropisetron fights cardiac hypertrophy by adjusting sirtuin family proteins (Sirts) and components of mitochondrial death pathway, Bcl‐associated X (BAX), Bcl‐2‐associated death promoter (BAD). Male Sprague–Dawley rats got divided into four groups, including control (Ctl), tropisetron (Trop), cardiac hypertrophy (Hyp), and hypertrophic rats under tropisetron treatment (Hyp + Trop). Pathological cardiac hypertrophy was induced by surgical abdominal aortic constriction (AAC). The increased expression of brain natriuretic peptide (BNP) in the Hyp group confirms the cardiac hypertrophy establishment. The mRNA levels of SIRT1, SIRT3, SIRT7, and BAD also upregulated in the hypertrophic group (p < 0.001). Postoperational administration of tropisetron for 3 weeks lowered the increased expression of BNP (p < 0.05) and BAD (p < 0.001), though the reduction of BAX expression was statistically insignificant (p > 0.05). Tropisetron treatment also restored the normal level of SIRT1/3/7 genes expression in the Hyp + Trop group (p < 0.05). Present findings suggest that tropisetron can suppress cardiomyocyte hypertrophy progression to heart failure by counteracting BNP, SIRT1, SIRT3, Sirt7, and BAD overexpression‐mediated apoptosis in a rat model of cardiac hypertrophy.
Oncogene‐mediated nuclear accumulation of lactate promotes epigenetic alterations to induce cancer cell proliferation
Authors: Bandopadhyay Shreya , Kamal Izaz M. , Padmanaban E. , Ghosh Damayanti D. , Chakrabarti Saikat , Roy Sib S. 
Published: March 2023

AbstractHomeobox gene families are associated with embryonic development and organogenesis. Pieces of evidence suggest that these Homeobox genes are also crucial in facilitating oncogenesis when mutated or overexpressed. Paired homeodomain transcription factor‐2 (PITX2), one of the members of this family, is involved in oncogenic regulation apart from its different development regulatory functions. PITX2 has been earlier shown to induce ovarian cancer cell proliferation through the activation of different signaling cascades. Increased cancer cell proliferation requires a constant supply of nutrients for both adenosine triphosphate and biomass synthesis, which is facilitated by altered cancer cell metabolism that includes enhanced glucose uptake and increased glycolytic rate. This present study highlights the involvement of PITX2 in enhancing the cellular glycolysis pathway in ovarian cancer cells through protein kinase B‐phosphorylation (phospho‐AKT). PITX2 expression correlates positively with that of the glycolytic rate‐determining enzyme, lactate dehydrogenase‐A (LDHA), in both high‐grade serous ovarian cancer tissues and common ovarian cancer cell lines. Interestingly, transient localization of enzymatically active LDHA in the nucleus was observed in PITX2‐overexpressed ovarian cancer cells. This nuclear LDHA produces higher concentrations of the glycolytic end product, lactate, which accumulates in the nuclear compartment resulting in decreased histone deacetylase (HDAC1/2) expression and increased histone acetylation at H3/H4. However, the mechanistic details of lactate–HDAC interaction are still elusive in the earlier reports. Our in silico studies elaborated on the interaction dynamics of lactate in the HDAC catalytic core through ligand‐binding studies and molecular dynamics simulation approaches. Blocking lactate production by silencing LDHA reduced cancer cell proliferation. Thus, PITX2‐induced epigenetic changes can lead to high cellular proliferation and increase the size of tumors in syngeneic mice as well. Taken together, this is the first report of its kind to show that the developmental regulatory homeobox gene PITX2 could enhance oncogenesis through enhanced glycolysis of tumor cells followed by epigenetic modifications.
A scoping review of intimate partner violence in hospitalized patients
Authors: Maitra Amrapali , Schnipper Jeffrey L. , Bain Paul A. , Mueller Stephanie K. 
Published: March 2023

AbstractBackgroundDespite the high prevalence and significant health effects of intimate partner violence (IPV), little is known about its associations with hospitalization.ObjectiveTo perform a scoping review of how IPV impacts hospitalization rates, characteristics, and outcomes in adult patients.Data SourcesA search of four databases (MEDLINE, Embase, Web of Science, and CINAHL) using a combination of terms including hospitalized patients and IPV revealed 1608 citations.Study Selection and Data ExtractionOne reviewer determined eligibility based on inclusion and exclusion criteria, which a second reviewer independently verified. Data were extracted and organized a posteriori into three categories based on research aim: (1) comparative studies of hospitalization risk associated with recent IPV exposure, (2) comparative studies of hospitalization outcomes by IPV exposure, and (3) descriptive studies of hospitalizations for IPV.ResultsOf the 12 included studies, 7 were comparative studies of hospitalization risk associated with IPV, 2 were comparative studies of hospitalization outcomes by IPV, and 3 were descriptive studies of hospitalizations for IPV. Nine out of 12 studies focused on specific patient populations. All but one study demonstrated that IPV was associated with increased risk of hospitalization and/or worse hospitalization outcomes. Six of the seven comparative studies showed a positive association between recent IPV and hospitalization risk.ConclusionThis review suggests that IPV exposure increases the risk of hospitalization and/or worsens inpatient outcomes in specific patient populations. Additional work is needed to characterize hospitalization rates and outcomes for persons who have experienced IPV in a broader, nontrauma population.
ENSO‐induced decadal variability in the tropical Pacific subsurface in CMIP6 models
Authors: Chen Yue , Huang Ping 
Published: March 2023

AbstractThe tropical Pacific decadal variability (TPDV) is an important component of the global interdecadal variability. Previous studies have shown that the TPDV in the sea surface temperature (SST) has two clear patterns, the El Niño–Southern Oscillation (ENSO)‐like and ENSO‐induced patterns, but the pattern of TPDV in the ocean subsurface is still a matter of debate in observations and models. The present study analyses the subsurface TPDV in the simulations of 26 CMIP6 models. The ENSO‐like and ENSO‐induced TPDVs in the subsurface are defined by the regression of the interdecadal anomalies of the oceanic subsurface temperature (Tsub) onto the PCs of two leading EOF modes of the interdecadal SST anomalies in the tropical Pacific. The pattern of the ENSO‐like TPDV in the subsurface shows high model consistency, whereas the ENSO‐induced TPDV in the subsurface has two distinct modes among the models, one with a centre in the central Pacific and the other showing a zonal dipole in the equatorial Pacific. The zonal pattern of the ENSO‐induced TPDV in the subsurface is mainly induced by the SST skewness in the equatorial eastern Pacific, which is further related to the surface heat flux feedback during La Niña.
Multiple solutions for a Schrödinger–Bopp–Podolsky system with positive potentials
Authors: Figueiredo Giovany M. , Siciliano Gaetano 
Published: March 2023

AbstractIn this paper, we prove existence of solutions for a Schrödinger–Bopp–Podolsky system under positive potentials. We use the Ljusternick–Schnirelmann and Morse Theories to get multiple solutions with a priori given “interaction energy.”
Dorsolateral Nigral Hyperintensity on 1.5 T Versus 3 T Susceptibility‐Weighted Magnetic Resonance Imaging in Neurodegenerative Parkinsonism
Authors: Grossauer Anna , Müller Christoph , Hussl Anna , Krismer Florian , Schocke Michael , Gizewski Elke , Mahlknecht Philipp , Scherfler Christoph , Wenning Gregor K. , Poewe Werner , Seppi Klaus , Heim Beatrice 
Published: March 2023

AbstractBackgroundAn absent dorsolateral nigral hyperintensity (DNH) is a common finding in patients with neurodegenerative parkinsonism at high or ultra‐high field susceptibility‐weighted magnetic resonance imaging (SWI).ObjectiveDespite increasing use of high field magnetic resonance imaging (MRI) in specialized centers, these scanners are still frequently unavailable in primary care or outpatient facilities and underdeveloped or emerging countries. Therefore, the aim of the present study was to evaluate the diagnostic utility of DNH assessment at 1.5 versus 3 T MRI to distinguish patients with neurodegenerative parkinsonism, including Parkinson's disease (PD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), from healthy controls (HC).MethodsAbsence of DNH was assessed on visual inspection of anonymized 1.5 T and 3.0 T SWI scans in a case–control study including 86 patients with neurodegenerative parkinsonism and 33 healthy controls (HC). All study participants were consecutively recruited to undergo 1.5 and 3 T MRI.ResultsOverall correct classification was 81.7% (95% CI, 72.6–88.4%) for 1.5 T and 95.7% (95% CI, 89.1–98.7%) for 3 T MRI in discriminating neurodegenerative parkinsonism from controls. However, while DNH was bilaterally present in all but one of the HC at 3 T MRI, it was rated as abnormal (at least unilateral absence) in 15 of 22 HC at 1.5 T MRI, resulting in a specificity of 31.8%.ConclusionsThe results of the present study demonstrate an insufficient specificity of visual assessment of DNH at 1.5 T MRI for the diagnosis of neurodegenerative parkinsonism.