bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D printing of chitooligosaccharide‐polyethylene glycol diacrylate hydrogel inks for bone tissue regeneration
Authors: Rajabi Mina , Cabral Jaydee D. , Saunderson Sarah , Ali M. Azam 
Published: April 2023

AbstractTo date, lack of functional hydrogel inks has limited 3D printing applications in tissue engineering. This study developed a series of photocurable hydrogel inks based on chitooligosaccharide (COS)‐polyethylene glycol diacrylate (PEGDA) for extrusion‐based 3D printing of bone tissue scaffolds. The scaffolds were prepared by aza‐Michael addition of COS and PEGDA followed by photopolymerisation of unreacted PEGDA. The hydrogel inks showed sufficient shear thinning properties required for extrusion 3D printing. The printed scaffolds exhibited excellent shape fidelity and fine microstructure with a resolution of 250 μm. By increasing the COS content, the swelling ratio of the scaffolds decreased, while the compressive strength increased. 3D printed COS‐PEGDA scaffolds showed high viability of human bone mesenchymal stem cells in vitro. In addition, scaffolds containing 2 wt% COS showed significantly higher alkaline phosphatase activity, calcium deposition, and bioactivity in simulated body fluid compared to the control (PEGDA). Altogether, 3D printed COS‐PEGDA scaffolds represent promising candidates for bone tissue regeneration.
IFI16/Ifi202 released from breast cancer induces secretion of inflammatory cytokines from macrophages and promotes tumor growth
Authors: Lim Ga Young , Cho Sun Wook , Ka Na‐Lee , Lee Kyung‐Hun , Im Seock‐Ah , Kim Seung‐Su , Hwang Sewon , Lee Mi‐Ock 
Published: April 2023

AbstractIn tumor microenvironment (TME), macrophages trigger and maintain inflammatory responses that promoting tumor progression. Many cellular proteins are secreted from tumors and modulate their own TME by modulating macrophage phenotypes. Recently, we reported that interferon‐γ‐inducible protein 16 (IFI16), which was identified as an innate immune DNA sensor recognizing foreign DNA, triggered type Ⅰ interferon responses in breast cancer (BC). However, whether IFI16 was released from BC and affects TME has not been studied. Here, we report that IFI16 and its mouse homolog Ifi202 were released from BC cells, but not from normal epithelial cells. Ifi202 induced secretion of proinflammatory cytokines such as Interleukin (IL)‐1β, IL‐6, and Tumor necrosis factor‐α from macrophages via binding toll‐like receptor 2 and activating downstream signaling pathway. Growth of allografted mouse BC 4T1 lacking Ifi202 was suppressed and accompanied with increased infiltration and cytotoxic activity of CD8+ T lymphocytes. Further, IFI16 was detected in sera of patients with BC. High expression level of IFI16 was associated with poor prognosis in patients with BC. Taken together, our findings suggest a novel role of IFI16/Ifi202 in TME, that elicits tumor promoting inflammation and thereby shaping immunosuppressive TME in BC.
Research progress on the role of ET‐1 in diabetic kidney disease
Authors: Zhang Shenghao , Li Xiaodan , Liu Siyu , Zhang Wanting , Li Meinuo , Qiao Chen 
Published: April 2023

AbstractDiabetic kidney disease (DKD) is one of the common complications of diabetes mellitus, which usually progresses to end‐stage renal disease and causes great damage to the health of patients. Endothelin‐1 (ET‐1), a molecule closely associated with the progression of DKD, has increased expression in response to high glucose stimulation and is involved in hemodynamic changes, inflammation, glomerular and tubular dysfunction in the kidney, causing an increase in proteinuria and a decrease in glomerular filtration function, ultimately leading to glomerulosclerosis and renal failure. This paper aims to review the molecular level changes, regulatory mechanisms, and mechanisms of action of ET‐1 under DKD, clinical trials of ET‐1 receptor antagonists in recent years and current problems, to provide basic information and new research directions and ideas for the treatment of DKD and ET‐1‐related research.
Advancing health equity: A qualitative study assessing barriers and facilitators of implementing hereditary breast and ovarian cancer risk screening tools in community‐based organizations
Authors: Bowen Alexandra , Gómez‐Trillos Sara , Curran Geoffrey , Graves Kristi D. , Sheppard Vanessa B. , Schwartz Marc D. , Peshkin Beth N. , Campos Claudia , Garcés Nathaly , Dash Chiranjeev , Aburto Luisa , Valencia‐Rojas Nancy , Hernández Gina , Villa Antonio , Cupertino Paula , Carrera Pilar , Hurtado‐de‐Mendoza Alejandra 
Published: April 2023

AbstractGenetic counseling and testing (GCT) inform cancer management for persons at risk for hereditary breast and ovarian cancer (HBOC). Community‐based organizations (CBOs) may play a role in identifying at‐risk Latinx individuals to connect them to GCT but data are lacking. Two academic centers and their four CBO partners planned to implement a validated questionnaire for HBOC risk screening (“HBOC risk screening tool”). This study aimed to assess CBO's preferences for HBOC risk screening tools, as well as the barriers and facilitators anticipated for future implementation. Pre‐implementation focus groups were conducted with CBO's staff. Discussions centered on current practices to identify and refer at‐risk patients. During the discussion, staff were asked to select one out of five validated HBOC risk screening tools to implement and to discuss anticipated barriers/facilitators for implementation. The four focus groups were coded and qualitative analyzed following the Consolidated Framework for Implementation Research (CFIR) and Health Equity domains. All CBOs chose the Family History Screen 7 (FHS‐7). Participants (N = 35) highlighted how the FHS‐7 was easy to adapt to better fit the target population and changing guidelines. They had positive attitudes toward implementing the screening tool, stressed how the culture of the organization positioned them to reach the target population, and noted barriers in different CFIR domains (e.g., low knowledge about HBOC and GCT referrals; scarce available resources). Participants pointed to barriers related to health equity domains including limited access to GCT and follow‐up care for uninsured and underinsured populations, challenges obtaining accurate family history, and immigration‐related barriers. CBOs highlighted the importance of partnering with other stakeholders to overcome barriers. Findings emphasize the need to develop multi‐level implementation strategies to overcome barriers and leverage facilitators. This study can inform the development of implementation toolkits for CBOs to implement HBOC screening tools to advance health equity.
Safety, efficacy, and timing of transplantation(s) in propionic and methylmalonic aciduria
Authors: Chakrapani Anupam , Stojanovic Jelena , Vara Roshni , De Nictolis Francesca , Spada Marco , Dionisi‐Vici Carlo 
Published: April 2023

AbstractPropionic (PA) and methylmalonic aciduria (MMA) share many clinical similarities, which include the risk of acute metabolic encephalopathies, and some long‐term complications, such as optic neuropathy, pancreatic involvement, developmental disability, and similar management approaches, but they also represent distinct clinical and biochemical entities. In the severe forms of PA and MMA, most long‐term complications cannot be prevented with conventional clinical management. Organ transplantation represents a form of partial enzyme replacement to improve the long‐term outlook for these disorders. There is evidence that early liver transplant in both disorders greatly improves metabolic stability and reduces the risk of long‐term complications. For MMA, early liver transplant reduces methylmalonic acid levels which in turns reduces its effects on kidneys, and therefore slows progression of chronic kidney disease. However, established organ damage cannot be reversed. For patients with MMA who present with chronic kidney disease, consideration should be given for combined liver and kidney transplants. Transplantation in PA and MMA carries a high risk of complications and requires highly specialised pre‐operative and peri‐operative management. Involvement of a multidisciplinary team is essential and should include metabolic team, nephrologist, hepatologist, hepatobiliary and renal transplant surgeons, anaesthesiologists, cardiologists, intensive care team, dieticians and specialist nurses. These patients require life‐long multidisciplinary follow‐up. There is increasing evidence in the literature on excellent short to medium‐term patient and allograft survival following transplantation when patients are managed by a multidisciplinary team in a specialist centre. Improved early diagnosis and reductions in transplant‐related mortality and morbidity have allowed early transplantation to be used electively to further improve the outcome.
No association of vaccination with inactivated COVID‐19 vaccines before conception with pregnancy complications and adverse birth outcomes: A cohort study of 5457 Chinese pregnant women
Authors: Zhao Yan , Zhao Yongbo , Su Xin , Zhou Yicheng , Zhang Ziyi , Zhang Yijun , Li Mengyuan , Jin Liping 
Published: April 2023

AbstractData on the safety of inactivated COVID‐19 vaccines in pregnant women is limited and monitoring pregnancy outcomes is required. We aimed to examine whether vaccination with inactivated COVID‐19 vaccines before conception was associated with pregnancy complications or adverse birth outcomes. We conducted a birth cohort study in Shanghai, China. A total of 7000 healthy pregnant women were enrolled, of whom 5848 were followed up through delivery. Vaccine administration information was obtained from electronic vaccination records. Relative risks (RRs) of gestational diabetes mellitus (GDM), hypertensive disorders in pregnancy (HDP), intrahepatic cholestasis of pregnancy (ICP), preterm birth (PTB), low birth weight (LBW), and macrosomia associated with COVID‐19 vaccination were estimated by multivariable‐adjusted log‐binomial analysis. After exclusion, 5457 participants were included in the final analysis, of whom 2668 (48.9%) received at least two doses of an inactivated vaccine before conception. Compared with unvaccinated women, there was no significant increase in the risks of GDM (RR = 0.80, 95% confidence interval [CI], 0.69, 0.93), HDP (RR = 0.88, 95% CI, 0.70, 1.11), or ICP (RR = 1.61, 95% CI, 0.95, 2.72) in vaccinated women. Similarly, vaccination was not significantly associated with any increased risks of PTB (RR = 0.84, 95% CI, 0.67, 1.04), LBW (RR = 0.85, 95% CI, 0.66, 1.11), or macrosomia (RR = 1.10, 95% CI, 0.86, 1.42). The observed associations remained in all sensitivity analyses. Our findings suggested that vaccination with inactivated COVID‐19 vaccines was not significantly associated with an increased risk of pregnancy complications or adverse birth outcomes.
Agricultural soil aggregation is affected by the crop root biomass rather than morphological characteristics
Authors: Ma Qiu‐Jin , Luan Feng , Jia Bin , Zhang Qian , Wang Lin , Cui Zengtuan , Li Xiao Gang 
Published: April 2023

AbstractBackgroundIn areas prone to water erosion, crop selection strategies should be based on assessment of their effects on soil structural properties.AimsThe present study compared the effects of the cultivation of forage maize (Zea mays L.) and forage oat (Avena sativa L.) and their cultivars on soil aggregation relative to potato (Solanum tuberosum L.) or wheat (Triticum aestivum L.) at a hydrothermally limited site on the Loess Plateau, China.MethodsThe water‐stable aggregate (WSA) distribution in soil was measured under three cultivars in each of maize, oat, wheat, and potato (a total of 12 cultivars from four crops) in their flowering stage of three cropping seasons, when root biomass was largest.ResultsIn each year, the water‐stable macroaggregates (>0.25 mm) content and mean weight diameter (MWD) of WSAs in the top 20 cm of soil did not differ between tested cultivars of every crop but increased under maize and oat, compared with those under wheat or potato. The increased soil aggregation under maize and oat, compared with wheat or potato, was consistent with the pattern of change in root biomass but was not consistent with the changes in root length density, root surface area, or root mean diameter across the crops. The water‐stable macroaggregates content and MWD of soil was positively correlated with root biomass across cultivars and crop species within each cropping season.ConclusionsWe suggest that increased root biomass under maize and oat relative to potato or wheat resulted in increased soil aggregation in maize and oat cultivated soils. It is demonstrated that, in areas prone to soil water erosion, planting high‐biomass‐yielding crops such as maize and oat is more beneficial for increasing soil aggregation and stability, compared with low‐biomass‐yielding crops such as wheat or potato.
Plant residues ameliorate pH of agricultural acid soil in a laboratory incubation: A meta‐analysis
Authors: Sulaiman Syazwan , Navaranjan Namasivayam , Hernandez‐Ramirez Guillermo , Sulaiman Zohrah 
Published: April 2023

AbstractBackgroundThe effect of plant residues on the pH of agricultural acid soil varies markedly across numerous studies, which has been attributed to differences in plant residue characteristics, soil initial properties, and experimental conditions.AimsThe aim of this study was to address the need to form a unified framework for the relationship between plant residue incorporation and acid soil pH in agricultural systems.MethodsA systematic compilation of data was performed through a keyword search in the Scopus database, which yielded 221 independent pairwise comparisons of soil pH across 23 published articles utilizing laboratory incubations. These data were then used to form a consensus on the effect of plant residue on acid soil pH via a meta‐analysis approach.ResultsOf the 221 pairwise comparisons, 91.4% of the cases showed a positive effect of plant residue in increasing acid soil pH. Overall, plant residue application significantly improved soil pH of acid soil (p ≤ 0.05) by 12.4% ± 1.0% regardless of the heterogeneity in plant, soil, and experimental attributes between studies. Our analysis also revealed that total alkalinity (≥ 80 cmol kg–1) and N (≥ 10 g kg–1) of plant residue provide the optimal ameliorative effect. This ameliorative effect is more pronounced in extremely acidic soil (pH 3.5–4.4) than at soil with pH > 5.5.ConclusionsThe insights gained through this meta‐analysis demonstrated the interplay between different plant residue, soil, and experimental attributes, which collectively influence the ameliorative effect of plant residue application to the pH of agricultural acid soil.
Soil organic carbon and nitrogen in aggregates in response to over seven decades of farmyard manure application
Authors: Abdalla Khatab , Gaiser Thomas , Seidel Sabine Julia , Pausch Johanna 
Published: April 2023

AbstractThe study aimed to evaluate the effects of long‐term fertilisation on soil aggregation and the associated changes in soil organic carbon (SOC) and nitrogen (N) pools in aggregates. The combined application of mineral fertiliser and manure improved soil aggregation, SOC and N content in aggregates, compared to manure or mineral fertiliser alone, and thus proved to be a suitable fertilisation strategy to increase C sequestration in agroecosystems.
Developing a South Pacific tephra framework: Initial results from a Samoan Holocene sequence
Authors: Bourne Anna J. , Sear David A. , Langdon Pete G. , Cronin Shane J. 
Published: April 2023

ABSTRACTTephra preserved in sediments form useful isochronous marker layers, linking disparate geological, palaeoenvironmental and archaeological records. The application of tephrochronology is greatly enhanced through the detection of macroscopically invisible tephra (cryptotephra). Here, we identify two discrete cryptotephra in Samoan lake sediments, the first identification of cryptotephra in the region outside of New Zealand. Geochemical data suggest one ash layer is from a local Samoan source, providing the first data on an eruption of this age, adding to knowledge of the local volcanic record. The second has a distinctive rhyolitic glass composition, which matches either that of Raoul Island in the Kermadec Arc (1800 km south of Samoa), or two currently submarine volcanoes in the Tongan Arc, ‘Volcano F’ and Lateiki/Metis Shoal (550 and 700 km south of Samoa, respectively). In all possible source cases, this points to a regionally significant eruption of a Kermadec–Tongan volcano at ca. 10 000 a bp. The study marks the first step in the establishment of a South Pacific tephra framework that can be used to answer questions about the synchronicity of changes in hydroclimate, vegetation and early Polynesian migration patterns, as well as providing more information on the volcanic history of Pacific island volcanoes.
Reconstruction of the palaeo‐sea level of Britain and Ireland arising from empirical constraints of ice extent: implications for regional sea level forecasts and North American ice sheet volume
Authors: Bradley SARAH L. , Ely JEREMY C. , Clark CHRIS D. , Edwards ROBIN J. , Shennan Ian 
Published: April 2023

ABSTRACTReconstructions of palaeo‐sea level are vital for predicting future sea level change and constraining palaeo‐ice sheet reconstructions, as well as being useful for a wide array of applications across Quaternary Science. Previous reconstructions of the palaeo‐sea level of Britain and Ireland relied on a circular tuning of glacio‐isostatic models: input ice sheet thicknesses and extents were iteratively altered to fit relative sea level data. Here we break that circularity by utilizing new data from the BRITICE‐CHRONO project, which constrains the position of the British–Irish ice sheet margin through time, and we compare derived glacio‐isostatic modelling to the rich relative sea level record. We test a combination of plausible ice thickness scenarios which account for the uncertainty of ice margin position over the North Sea, demonstrating the region where regional sea level data could distinguish between different glaciation scenarios. Our optimal reconstruction is then combined with several global‐scale reconstructions. As the signal of the British–Irish Ice Sheet is constrained, we demonstrate how the relative sea level record of Britain and Ireland can be used to test reconstructions of far‐field ice sheets (e.g. Antarctica, Eurasia and the Laurentide). The derived palaeo‐topography data are likely to be useful for multiple disciplines. Finally, our improved method of sea level reconstruction impacts predictions of contemporary vertical land motion.
Anti‐fatigue properties of the ethanol extract ofMoringa oleiferaleaves in mice
Authors: Bian Xiangyu , Wang Yawen , Yang Renren , Ma Yuying , Dong Weiyun , Guo Changjiang , Gao Weina 
Published: April 2023

AbstractBACKGROUNDMoringa oleifera(M. oleifera) leaves are rich in nutrients and bioactive ingredients. This study was aimed at evaluating the anti‐fatigue effect of the ethanol extract ofM. oleiferaleaves (MLEE) on mice and its primary mechanism of action using a weight‐loaded forced swimming test. In the present study, MLEE was prepared by ultrasound‐assisted extraction, and its anti‐fatigue effect and antioxidant capacity were evaluated in mice. Mice were administrated MLEE (320 mg kg−1body weight) for 15 days.RESULTSMLEE supplementation significantly increased levels of glucose and non‐esterified fatty acids (NEFA), while decreasing levels of lactate and blood urea nitrogen in serum (P < 0.05); the levels of glycogen in the liver and muscle were also increased, as was the activity of glycogen synthase and the level of NEFA in muscle (P < 0.05). According to a Western blot analysis, MLEE increased the expression of AMPKα1, JNK, AKT and STAT3 in the muscle of mice.CONCLUSIONOur findings indicate that MLEE has an anti‐fatigue effect via the AMPK‐linked route, which enables it to control energy metabolism and enhance antioxidant enzyme activity. © 2023 Society of Chemical Industry.
Is travel bragging in the eye of the beholder? Bragger and audience perspectives
Authors: Liu Hongbo , Li Xiang (Robert) , Cohen Scott 
Published: April 2023

AbstractTravel bragging refers to showing off or boasting about travel experiences. Despite its ubiquity on social media, travel bragging has been relatively under‐researched. This study examines travel bragging from a dual perspective of both braggers and audiences. Based on 30 semi‐structured interviews with participants who frequently posted or bragged about travel experiences and who had been frequently exposed to others' travel bragging on social media, we provide the first systematic conceptualization of travel bragging. We highlight the perception gaps between travel braggers and the audience regarding travel bragging, while uncovering the positive and negative effects of travel bragging and associated theoretical underpinnings.
Kinetics of hydrogenation of dimethyl 1,4‐cyclohexanedicarboxylate to 1,4‐cyclohexanedimethanol
Authors: Zhou Xiangze , Shen Weihua , Fang Yunjin 
Published: April 2023

AbstractThe kinetics of dimethyl 1,4‐cyclohexanedicarboxylate (DMCD) hydrogenation, via the half‐hydrogenated product methyl 4‐(hydroxymethyl) cyclohexanecarboxylate (MHMCC), to 1,4‐cyclohexanedimethanol (CHDM) in gas phase was established over CuMnAl catalyst. The intrinsic kinetic experiments were carried out on a fixed‐bed reactor under a wide range of reaction conditions with temperature varied from 493 to 523 K, pressure varied from 4 to 6 MPa, and weight hourly space velocity of DMCD varied from 0.948 to 3.792 h−1. Eight rival possible two‐site LHHW models were proposed to simulate the experimental results. The model involving dissociative adsorption of esters and surface reaction as the rate‐determining step was found to fit the experimental data best. The rather large activation energy values (138.4 and 121.4 kJ·mol−1) of two reactions (DMCD to MHMCC and MHMCC to CHDM) suggest that the reactions are both temperature sensitive. The coefficients of determination (R2) for DMCD conversion and CHDM selectivity were 0.989 and 0.983 respectively. Statistical and thermodynamic test further verified the reliability of the results.