bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reforming healthcare in the Netherlands: practical population health management and the Plot model: A questionnaire survey and focus group study to assess the willingness and readiness of six regions in the Netherlands
Authors: Minderhout Rosa Naomi , van Ede Annefrans FTM , Voragen Leonie , Verheijen Carl , Vos Hedwig MM , Numans Mattijs E , Stein K Viktoria , Bruijnzeels Marc A 
Published: March 2023

Objective: As in many other countries, the Netherlands is facing challenges in the provision of healthcare to its population. To ensure the population remains in good health in coming decades, an integrative approach to the many factors that influence health and health outcomes is needed. Population health management is gaining interest as a strategic framework for systems change in healthcare organisations. Based on population health management, the Dutch HealthKIC has developed the ‘Plot model’, which takes a regional perspective. The aim of this study was to detail the extent to which six prospective regions in the Netherlands were ready and willing to implement population health management using the Plot model, guided by the Five Lenses Model. Methods: Using an exploratory focus group reporting study, we involved stakeholders from six regions in the Netherlands. Thematic analysis followed the five predesigned dimensions of a validated cooperation model. Results: The study uncovered the potential for realisation of model aims, as assessed by an expert team, regarding shared ambition, mutual gains, relationship dynamics, organisational dynamics and process management. The exploratory questionnaire suggested that organisational dynamics is the least integrated topic in all areas, followed by process management, a finding confirmed in focus groups. Conclusion: The building themes of the Five Lenses Model all represent preconditions for the success of integration in the prospective regions. The present study showed that while some themes were reasonably represented in prospective regions, no region was satisfactory for all themes.
Educational videos about dyspareunia and the assessment of their quality and reliability: An observational study
Authors: Lopez-Brull Aida , Perez-Dominguez Borja , Plaza-Carrasco Maria , Casaña Jose 
Published: March 2023

Objective: The aim of this study was to analyze the characteristics, availability, quality and reliability of the information found in educational videos about dyspareunia. Methods: A systematic search was carried out on YouTube searching for educational videos about dyspareunia. Video quality scores were assessed with the DISCERN instrument, Global Quality Scale (GQS) and QUEST tool. Video popularity was evaluated with the Video Power Index (VPI). Interobserver agreement and statistical correlations of the assessment scores were also carried out. Results: The first 150 videos that appeared were selected. The mean number of views was 35,513.1 views (SD 71,443.9), the mean video length was 05:39 (SD 04:38), the mean days online was 1,396.3 days (SD 706), the mean view ratio was 29.8 (SD 68.1), the mean Like count was 333 likes (SD 1000.6), the mean Dislike count was 13 dislikes (SD 25.3) and the mean VPI Index was 92.1% (SD 16.4%). The mean values for the DISCERN instrument were for Observer-1 40.9 points (SD 9.9) and for Observer-2 39.3 points (SD 8.5). Mean values for the GQS score were for Observer-1 3.1 points (SD 0.9) and for Observer-2 3.0 points (SD 0.8). Finally, mean values for the QUEST tool were for Observer-1 13.3 points (SD 4.1) and for Observer-2 13.1 points (SD 4.2). Conclusions: The quality of the videos found on YouTube about dyspareunia, according to DISCERN, GQS, and QUEST scores, are average. Videos with high quality scores were produced by Academic Institutions, despite having lower frequency visit rates.
Monkeypox epidemiology, clinical presentation, and transmission: a systematic review
Authors: Sharma Ashima , Prasad Hari , Kaeley Nidhi , Bondalapati Aparna , Edara Lokesh , Kumar Y. Ajay 
Published: March 2023

Abstract
Background
The new zoonotic viral infection, monkeypox, is a global health issue. Our study aimed at studying the epidemiology, clinical presentation, complications, case fatality rate, and transmission among the present cases of monkeypox infection.

Methods
Articles were searched in PubMed, Google Scholar, and Science Direct databases using the keywords “Monkeypox” [MeSH] or “Monkeypox virus” (MeSH). Narrative reviews, conference abstracts, commentaries, and articles in languages other than English were excluded.

Results
From three databases, 1442 studies were identified. Seven hundred ten articles were excluded because they included data before 2022, leaving 732 items for screening. After filtering 320 data due to data duplication, 412 remained. Due to the inclusion of systematic reviews, meta-analyses, reviews, comments, and articles in languages other than English, 257 were excluded. Eligibility based on full-text review was applied to the remaining 155, excluding 129. So, the study covered a total of remaining 26 articles. We studied 2352 confirmed cases from published literature, accounting for approximately 4% of infected cases worldwide. Around 81.71% of patients have a bisexual or men having sex with men (MSM) preference. Approximately 30.18% of confirmed cases were HIV positive. Male sex was also identified as a risk factor in our review.

Conclusion
Monkeypox human-to-human and human-to-animal transmission are rising. Thus, it is essential to do research on the prevention, clinicodemographic trends, and treatment of monkeypox. Understanding this will enable us to treat monkeypox patients with a targeted and focused approach.
Temporal and spatial variations in local sex ratios in a suburban population of the European green toad Bufotes viridis
Authors: Staufer Martina , Burgstaller Stephan , Horvath András , Landler Lukas 
Published: March 2023

AbstractBackgroundSex ratios of animal populations are important factors of population demographics. In pond-breeding amphibians, the operational sex ratio (OSR) among the breeding population is usually male-biased. Also, in European green toads (Bufotes viridis), males usually outnumber females at breeding sites, while the sex ratio of the total adult population (ASR) is assumed to be balanced. It has been suggested that sex-specific breeding behavior causes male-predominance at the breeding sites. We used a dataset of 5 years of street patrols to test this hypothesis. For this we analyzed local sex ratios of green toads in terrestrial habitats and at two artificial breeding ponds. We expected temporal and/or spatial changes of local sex ratios which would indicate sex dependent differences in breeding behavior.ResultsOverall observed ASR among 2111 green toads, counted in the course of street patrols from 2016 to 2020, was slightly male-biased (ASR = 0.56, annual ASRs = 0.49–0.63). Based on the data of 1631 toads (920 males, 711 females) captured within a radius of 300 m around nine main breeding sites, temporal and spatial variations in local ASRs were evaluated. Resulting values were compared to the calculated OSR at two artificial breeding ponds in 2021 (645 adult: 553 males, 92 females). Estimates predict more equally distributed females and males prior to the main breeding season. During breeding season, males predominated at both breeding sites (B1: 0.83, B2: 0.89), whereas females are estimated to outnumber males in terrestrial habitats. Proportions of females highly significantly increased with advancing time of the year and increasing distance to the breeding sites. While males tended to accumulate in proximity to water bodies, females dispersed soon after breeding to more distant areas.ConclusionsObserved sex ratios in the studied green toad population changed with time and sampling site, deviating from the population-wide sex ratio. Expanding sampling effort in amphibian conservation assessments in time and space, i.e., outside the main breeding season and away from the breeding sites, would be important to encompass such variations.
Seven-year outcomes following intensive anti-vascular endothelial growth factor therapy in patients with exudative age-related macular degeneration
Authors: Lukacs Regina , Schneider Miklos , Nagy Zoltan Zsolt , Sandor Gabor Laszlo , Kaan Kinga , Asztalos Antonia , Enyedi Lajos , Pek Gyorgy , Barcsay Gyorgy , Szabo Antal , Borbandy Agnes , Kovacs Illes , Resch Miklos Denes , Papp Andras 
Published: March 2023

Abstract
Background
Anti-vascular endothelial growth factor (VEGF) therapy is currently the most effective therapy of exudative age-related macular degeneration (AMD). The aim of this study was to assess long-term benefits of intensive aflibercept and ranibizumab anti-VEGF therapy in patients with exudative AMD.

Methods
Two clinical trial sites recruited their original subjects for a re-evaluation 7 years after the baseline visit of the phase-3 Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration (VIEW 2) trial.
Forty-seven eyes of 47 patients with AMD originally treated with ranibizumab (14 eyes) or aflibercept (33 eyes) were included.

Results
Mean number of injections was 17.8 ± 3.0 during participation in the VIEW 2 trial. Fourteen of 47 (30%) eyes were given additional injections with a mean number of 5.7 ± 4.5 after the trial. At a mean follow-up time of 82 ± 5 months best corrected visual acuity (BCVA) remained stable or improved (≤ 10 letters lost) in 55% of patients in the entire study population, in 43% in the ranibizumab group and in 60% in the aflibercept group. In both groups combined mean BCVA was 54 ± 13 letters at baseline, 65 ± 17 letters at the end of the intensive phase and 45 ± 25 letters at the end of follow-up. There was no statistically significant difference in BCVA between the two groups at baseline (p = 0.88) and at the end of follow-up (p = 0.40). Macular atrophy was observed in 96% of eyes, average area was 7.22 ± 6.31 mm2 with no statistically significant difference between groups (p = 0.47). Correlation between BCVA at end-of-follow-up and the area of atrophy was significant (p < 0.001). At the end of follow-up, fluid was detected in 7 of 47 eyes (15%) indicating disease activity.

Conclusion
Long-term efficacy of aflibercept and ranibizumab was largely consistent. Following a two-year intensive therapy with as-needed regimen, BCVA was maintained or improved in almost half of the patients and in the ranibizumab group and more than half of the patients in the aflibercept group with very few injections. In a remarkable proportion of eyes, BCVA declined severely which underlines the need for long-term follow-ups and may indicate a more prolonged intensive therapy.

Trial registrations
VIEW 2 study: ClinicalTrials.gov ID: NCT00637377, date of registration: March 18, 2008.
Long-term follow-up: IRB nr.: SE RKEB 168/2022, ClinicalTrials.gov ID: NCT05678517, date of registration: December 28, 2022, retrospectively registered.
Laser in situ keratomileusis versus Artisan lens implantation in correcting ametropia after penetrating keratoplasty for keratoconus
Authors: Feizi Sepehr , Javadi Mohammad Ali , Bineshfar Niloufar , Esfandiari Hamed 
Published: March 2023

Abstract
Purpose
To compare the long-term safety and efficacy of laser in situ keratomileusis (LASIK) with Artisan phakic intraocular lens implantation to correct refractive errors after penetrating keratoplasty (PK) for keratoconus.

Methods
This retrospective comparative interventional case series included a total of 33 consecutive keratoconus eyes that had previous PK and received subsequent LASIK (n = 16) or Artisan lens implantation (n = 17) were included in this study. Outcome measures were uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), refractive error, and complications.

Results
Postoperatively, the UDVA of ≥20/40 was achieved in none of the LASIK group compared to 62.5% of eyes in the Artisan group (P < 0.001); the respective values for CDVA of ≥20/40 were 87.5 and 94.1% (P = 0.51). Spherical equivalent refraction decreased from − 6.97 ± 1.50 D preoperatively to − 4.20 ± 2.05 D postoperatively in the LASIK group (P < 0.001) and from − 10.79 ± 2.15 D preoperatively to − 2.13 ± 1.23 D postoperatively in the Artisan group (P < 0.001). There was no significant change in the refractive astigmatism in LASIK group (P = 0.30) or Artisan group (P = 0.11). The efficacy and safety indices were significantly better for Artisan (0.82 ± 0.34 and 1.13 ± 0.30, respectively) than for LASIK (0.22 ± 0.17 and 0.85 ± 0.24, respectively, P ≤ 0.006 for both comparisons). While refractive error changed significantly from postoperative year 3 to the final visit in the LASIK group, it remained stable in the Artisan group through follow-up period. No significant complications were observed in any group.

Conclusion
Artisan lens implantation provided superior and stable visual outcomes compared to LASIK for the management of post PK refractive errors in keratoconus eyes.
Cross-sectional study of the relationship between trait emotional intelligence and career adaptability of Chinese youths
Authors: Pong Hok-Ko , Leung Chi-Hung 
Published: March 2023

Abstract
Background
Young people often experience dramatic changes, both psychologically and physically, as they are transiting from students to working adults. However, there is still a lack of empirical studies on the relationship between the trait emotional intelligence and the career adaptability of youths in the Asia-Pacific region. This research examines that relationship in Chinese youths in Hong Kong.

Method
Cross-sectional data (N = 500) was collected from two universities in 2019 and 2020. The 2019 sample was made up of 256 Chinese university students (117 males, 139 females; ages 21-25). The 2020 sample included 244 Chinese university students (132 males, 112 females; ages 21-25). The participants were asked to complete the Wong and Law Emotional Intelligence Scale (WLEIS) to evaluate their emotional intelligence in the domains of self-emotion appraisal, other people's emotion appraisal, regulation of emotion, and use of emotion. Participants completed the Career Adapt-Abilities Scale (CAAS) to assess their career adaptability in the areas of concern, control, curiosity, and confidence.

Results
All domains of trait emotional intelligence were positively associated with career adaptability. Multiple Regression analysis showed that self-emotion appraisal and appraisal of other people's emotional were the most predictive factors in terms of career adaptability. Together, these two dimensions of emotional intelligence explain 12.5%, 26.2%, 13.4% and 69.4% respectively of the variance in students’ concern, control, curiosity, and confidence in relation to career adaptability.

Conclusion
The results highlight the importance of emotional intelligence in career adaptability. It is thus of value to study further whether career adaptability of young people may improve if emotional intelligence is incorporated into the student curriculum. The findings offer valuable insights for educators and teachers who are responsible for well-rounded development of students, and will thereby foster healthy lifestyles, stable emotional well-being and greater career adaptability in adolescents.
Involvement of inflammasomes in tumor microenvironment and tumor therapies
Authors: Zhang Ziqi , Li Xue , Wang Yang , Wei Yuquan , Wei Xiawei 
Published: March 2023

AbstractInflammasomes are macromolecular platforms formed in response to damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation would cause maturation of interleukin-1 (IL-1) family members and gasdermin D (GSDMD), leading to IL-1 secretion and pyroptosis respectively. Several kinds of inflammasomes detecting different types of dangers have been found. The activation of inflammasomes is regulated at both transcription and posttranscription levels, which is crucial in protecting the host from infections and sterile insults. Present findings have illustrated that inflammasomes are involved in not only infection but also the pathology of tumors implying an important link between inflammation and tumor development. Generally, inflammasomes participate in tumorigenesis, cell death, metastasis, immune evasion, chemotherapy, target therapy, and radiotherapy. Inflammasome components are upregulated in some tumors, and inflammasomes can be activated in cancer cells and other stromal cells by DAMPs, chemotherapy agents, and radiation. In some cases, inflammasomes inhibit tumor progression by initiating GSDMD-mediated pyroptosis in cancer cells and stimulating IL-1 signal-mediated anti-tumor immunity. However, IL-1 signal recruits immunosuppressive cell subsets in other cases. We discuss the conflicting results and propose some possible explanations. Additionally, we also summarize interventions targeting inflammasome pathways in both preclinical and clinical stages. Interventions targeting inflammasomes are promising for immunotherapy and combination therapy.
Occurrence features of intermediate descending layer and Sporadic E observed over the higher mid-latitude ionospheric station of Moscow
Authors: Oikonomou Christina , Leontiou Theodoros , Haralambous Haris , Gulyaeva Tamara L. , Panchenko V. A. 
Published: March 2023

AbstractNine years of ionograms from a higher mid-latitude ionospheric station (Moscow) are analyzed, by applying the ‘height–time–intensity’ (HTI) technique along with Spectrum (Lomb periodogram) analysis with the aim to investigate the daily and seasonal variability of sporadic E (Es) and intermediate descending layers (IDLs). Es and IDL traces are observed over Moscow, which are characterized by a 12-h periodicity prevailing throughout the year. Shorter periodicities in IDL and Es occurrence are also observed. A 6-h periodicity in Es and IDL dominates during November and December, while an 8-h periodicity is found mainly from October to February for IDL and in July for Es. These periodicities are primarily induced by the semi-, quarter- and terdiurnal thermospheric tides, respectively. Our results also establish the systematic and widespread manifestation of shorter-scale (4.8- and 4-h) periodicities observed mainly for IDL and less frequently for Es only during December and January, in the nine years considered, which is most probably linked to higher-order solar tides.
Graphical Abstract
Hotspots of un-iodized salt availability among Ethiopian households, evidence from the national survey data
Authors: Muluneh Atalay Goshu , Merid Mehari W. Mariam , Kassa Getahun Molla 
Published: March 2023

Abstract
Background
Universal salt iodization was started before decades but there are communities using the un-iodized salt till now. More than one-tenth of the Ethiopian community uses un-iodized salt.

Objective
This study aimed to identify the hotspots and associate factors of un-iodized salt availability in Ethiopia based on Ethiopian national household survey data.

Methods
We conducted an in-depth analysis of the Ethiopian Demographic and Health Survey 2016 data. A total of 15,567 households were included in the final analysis. We cleaned and weighed the data using Stata version 16 software and descriptive outputs were reported in graphs and tables. We computed the weighted prevalence of un-iodized salt and prepared it for spatial analysis. Global-level spatial autocorrelation, hotspot analysis using the Getis-Ord Gi* statistics, and spatial interpolation using empirical Bayesian interpolation were executed using ArcGIS 10.3 to predict the magnitude of un-iodized salt at the national level. The binary logistics regression model was used to identify the contributing factors of un-iodized salt utilization. Model goodness of fit was tested with Hosmer and Lemeshow goodness-of-fit test (P = 0.96). Finally, the adjusted odds ratio (AOR) with 95% CI was reported to identify significant factors.

Results
The magnitude of un-iodized salt availability was 14.19% (95% CI: 13.65, 14.75) among Ethiopian households. Un-iodized salt hotspots were found in Afar, Somalia, and Benishangul Gumuz regions. Compared to poorest wealth index: poorer (AOR = 0.55, 95% CI: 0.48, 0.64), middle (AOR = 0.51, 95% CI: 0.44, 0.60), richer (AOR = 0.55, 95% CI: 0.47, 0.64), and richest (AOR = 0.61, 95% CI: 0.50, 0.75); compared to uneducated household head: heads with secondary (AOR = 0.72, 95% CI: 0.60, 0.67) and above secondary (AOR = 0.54, 95% CI: 0.43, 0.67) education reduced the odds of un-iodized salt viability, while households living in highland (AOR = 1.16, 95% CI: 1.05, 1.29) had increased the odds of un-iodized salt availability.

Conclusion
More than a tenth of the households in Ethiopia uses un-iodized salt. Hotspots of un-iodized salt availability were found in Somali and Afar regions of Ethiopia. Better wealth index and education of the household heads reduces the odds of un-iodized salt availability while living in a high altitude above 2200 m increases the odds of un-iodized salt availability in Ethiopia.
Comparison between ultrasound-guided transversus abdominis plane block and quadratus lumborum block for open nephrectomy surgeries
Authors: Mohamed Ahmed Nasser , Afifi Galal Abou-elseoud , Shokeir Mohamed Hossam , Samir Ghada M. , Eldin Doaa M. Kamal 
Published: March 2023

AbstractBackgroundThis prospective randomized study was performed on 80 patients, 21–60 years old, scheduled for open nephrectomy surgery. Patients were equally allocated to two groups: the transversus abdominis plane block (TAPB) group and the quadratus lumborum block (QLB) group. Both groups received 0.3 ml/kg of bupivacaine 0.25% on the side of the operation. Total postoperative pethidine consumption, time to rescue analgesia, postoperative visual analogue scale (VAS), and pethidine-related postoperative nausea and vomiting (PONV) were recorded.ResultsTotal postoperative pethidine consumption was significantly lower in the QLB group: 73.75 ± 23.99 mg versus 115.63 ± 31.87 mg in the TAPB group. Time to 1st rescue analgesia was significantly prolonged in the QLB group: 477.075 ± 49.2 min versus 430.825 ± 48 min in the TAPB group. The VAS was significantly lower in the QLB group, on arrival to the Post-Anesthesia Care Unit (PACU), and at 1, 4, 8, and 12 postoperative hours. At 16 and 24 postoperative hours, both groups showed nonsignificant differences in the VAS scores. In the QLB group, 20% of patients had PONV versus 35% of patients in the TAPB group with no significant difference.ConclusionsQLB efficiently reduced pain after open nephrectomy surgeries, in terms of quality and duration of pain control compared to TAPB.Trial registrationFMASU MD 90a/2021/2022. The trial was registered on the 23rd of May 2021, with Pan Africa Clinical Trials Registry (PACTR202110858627849) on 27 October 2021