bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro efficacy of synthetic lawsone derivative disinfectant solution on removing dual-species biofilms and effect on acrylic denture surface properties
Authors: Manuschai Jutharat , Lomlim Luelak , Ratti Pichayaporn , Kara Jiraporn , Naorungroj Supawadee 
Published: September 2023

AbstractCandida albicans (C. albicans) and Streptococcus mutans (S. mutans) biofilms involve in denture stomatitis. This study compared compound 1 to 2% chlorhexidine gluconate (CHX), Polident, and distilled water (DW) in biofilms reduction and effect on polymethylmethacrylate acrylic (PMMA) properties. The structure of lawsone (naphthoquinone derivative) was modified by the addition of an alkylnyloxy group to yield compound 1. Dual-species biofilms of C. albicans and S. mutans were developed on PMMA discs. The colony-forming unit count measured the number of residual biofilm cells after exposure to the test agents. PMMA discs were examined for color stability, surface roughness, hardness, and chemical structure after 28 days. At 3 min, compound 1 was less effective than CHX in reducing C. albicans (p = 0.004) and S. mutans (p = 0.034) but more effective than Polident in reducing C. albicans (p = 0.001). At 15 min, no viable cells were detectable for compound 1 and its effectiveness was comparable to CHX (p = 0.365). SEM showed fungal cell surface damages in CHX, compound 1 and Polident groups. Only color change was affected by time (p < 0.001) and type of test agent (p = 0.008), and only CHX reached a clinical perception level. Compound 1 is a promising agent for removing biofilm from the PMMA surface without substantially degrading surface properties.
Analysis of clinical features and identification of risk factors in patients with non-alcoholic fatty liver disease based on FibroTouch
Authors: Liao Yan , Liu Lei , Yang Jiayao , Zhou Xiaoli , Teng Xiaoli , Li Yixi , Wan Ying , Yang Jian , Shi Zhaohong 
Published: September 2023

AbstractOur aim was to explore the correlation between ultrasound attenuation parameter (UAP) and liver stiffness measurement (LSM) based on FibroTouch (China) and clinical features in patients with non-alcoholic fatty liver disease (NAFLD), so as to provide a certain basis for the clinical application of FibroTouch in NAFLD. Hepatic steatosis and fibrosis in patients with NAFLD were graded according to FibroTouch, and the relationship between steatosis and fibrosis levels and clinical characteristics was retrospectively analyzed. Hepatic steatosis was positively related with weight, BMI, waist, hyperlipidemia, hyperuricemia, FBG, UA, TG, ALT, AST, GGT, LSM and hepatic fibrosis grading, and was negatively related with gender (male), age and AST/ALT ratio. Hepatic fibrosis was positively related with age, BMI, waist, hypertension, FBG, ALT, AST, GGT, NFS, APRI, FIB-4, UAP and hepatic steatosis grading, and was negatively related with blood platelet (PLT) counts. Moreover, BMI, waist, TG, ALT and LSM were independent risk factors of hepatic steatosis, while decreased PLT counts, AST and UAP were independent risk factors of hepatic fibrosis. Body mass parameters, metabolic risk factors and liver function indicators increase the risk of hepatic steatosis and fibrosis in patients with NAFLD, and UAP and LSM can interact with each other.
Neoadjuvant chemotherapy reduces the levels of HMGB1 and E-cadherin in patients with breast cancer
Authors: Su Qingchang , Wang Xin , Zhu Rongchen , Liu Cuicui , Sun Shanping 
Published: September 2023

AbstractThis study investigated the changes in serum tumor marker levels in patients with breast cancer (BC) after neoadjuvant chemotherapy (NACT) and their potential as prognostic factors in NACT. A total of 134 consecutive patients with BC treated at our hospital between January 2019 and December 2021 were retrospectively analyzed. Patients were treated with NACT based on the docetaxel, epirubicin, and cyclophosphamide (TEC) regimen and assessed for marker levels, T cell subsets, and therapeutic outcomes. Receiver operating characteristic (ROC) curves were constructed to evaluate the predictive performance of the markers. Outcome assessments showed that NACT effectively reduced the tumor size, leading to increased complete remission, partial remission, stable disease, and significantly reduced disease progression. Improved immune function has also been observed after NACT. The levels of two (E-cadherin and HMGB1) out of five markers (CA153, CK19, CEA, E-cadherin, and HMGB1) were significantly reduced after NACT before surgery compared with those at admission, suggesting that NACT modulates the levels of biomarkers. ROC analysis revealed that the area under the curve (AUC) of HMGB1 and E-cadherin combination was 0.87 for discrimination of therapeutic response with a sensitivity and specificity of 91.3% and 88.4%, respectively. Serum tumor marker levels were reduced after NACT in patients with BC. The reduction was most prominent for HMGB1, followed by E-cadherin. These biomarkers can be used to predict the therapeutic response to NACT with an AUC of 0.87, thus offering a new tool to monitor treatment progress in NACT for patients with BC.
A study of allergen detection panel in Guangzhou, southern China based on real-world data from the past 7 years
Authors: Hu Haisheng , Huang Huimin , Liao Chenxi , Li Aoli , Zhang Teng , Liang Xueqing , Sun Baoqing 
Published: September 2023

AbstractThis study aims to reduce the cost of allergen testing for Guangzhou, China by limiting the number of allergens for which patients are tested, and provide a testing panel to improve diagnostic and therapeutic efficiency. This retrospective study of real-world data from 2012 to 2019 included 39,570 patients with suspected allergies in Guangzhou, southern China. All the patients were tested for one or more of the following allergens serum specific immunoglobulin E (sIgE): Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat dander, dog dander, Artemisia vulgaris, Aspergillus fumigatus, Alternaria alternata, Blattella germanica, egg whites, milk, wheat, peanuts, soybeans, Cancer pagurus, and Penaeus monodon by PhadiaCAP 1000. Totally, only the positive rates of allergens sIgE in D. farinae, D. pteronyssinus, milk, egg whites, B. germanica, C. pagurus, A. alternata, and P. monodon were > 10%, the other allergens were between 4–7%. Moreover, among the allergic diseases, dust mites exhibited the overall highest positive rate, followed by milk and B. germanica. In children, milk was the main allergen, whereas in adults, mites, cockroaches, shrimp, and crab allergens had higher positive rates. The optimal scale analysis shows that the multiple sensitization classification of patients can be divided into three categories: I D. farinae and D. pteronyssinus; II. C. pagurus, P. monodon, and B. germanica; III. Milk and egg whites. Generally, a panel including 4 allergens can detect > 90% of the potential allergy in this local population. In Guangzhou, southern China, D. farinae, milk, B. germanica, and A. alternata as a panel screening allergy for suspected allergic patients was suggested base on this study.
Non-electrostatic interactions associated with aggregate formation between polyallylamine and Escherichia coli
Authors: Nakatsuji Masatoshi , Sato Natsuki , Sakamoto Shiho , Watanabe Koji , Teruuchi Yoko , Takeuchi Minoru , Inui Takashi , Ishihara Hideki 
Published: September 2023

AbstractBacterial aggregation by mixing with polymers is applied as pretreatment to identify pathogens in patients with infectious diseases. However, the detailed interaction between polymers and bacteria has yet to be fully understood. Here, we investigate the interaction between polyallylamine and Escherichia coli by isothermal titration calorimetry. Aggregation was observed at pH 10 and the binding was driven by favorable enthalpic gain such as the electrostatic interaction. Neither aggregation nor the apparent heat of binding was observed at pH 4.0, despite the strong positive charge of polyallylamine. These results suggest that intermolecular repulsive forces of the abundant positive charge of polyallylamine cause an increased loss of conformational entropy by binding. Non-electrostatic interaction plays a critical role for aggregation.
Endoglin inhibitor TRC105 with or without bevacizumab for bevacizumab-refractory glioblastoma (ENDOT): a multicenter phase II trial
Authors: Ahluwalia Manmeet S. , Rogers Lisa R. , Chaudhary Rekha , Newton Herbert , Ozair Ahmad , Khosla Atulya A. , Nixon Andrew B. , Adams Bonne J. , Seon Ben K. , Peereboom David M. , Theuer Charles P. 
Published: September 2023

Abstract
Background
Glioblastoma (GBM), the most lethal primary brain tumor, has limited treatment options upon recurrence after chemoradiation and bevacizumab. TRC105 (carotuximab), a chimeric anti-endoglin (CD105) antibody, inhibits angiogenesis and potentiates activity of VEGF inhibitor bevacizumab in preclinical models. This study sought to assess safety, pharmacokinetics, and efficacy of TRC105 for bevacizumab-refractory GBM.

Methods
We conducted a pre-registered (NCT01564914), multicenter, open-label phase II clinical trial (ENDOT). We administered 10 mg/kg TRC105 monotherapy (first cohort) in adults with GBM and radiographic progression following radiation, temozolomide and bevacizumab therapy. Primary outcome was median time-to-progression (TTP), amended after first cohort’s enrollment to median overall survival (mOS). Secondary outcomes were objective response rate, safety and tolerability, and progression-free survival (PFS).

Results
6 patients were enrolled in TRC105 monotherapy cohort. Median TTP and PFS of 5 evaluable patients receiving monotherapy was 1.4 months, in whom plasma VEGF-A levels were elevated post-therapy. Lack of response led to protocol amendment, and second cohort’s addition of bevacizumab+TRC105 with primary endpoint of mOS. 16 patients were enrolled in bevacizumab+TRC105 cohort. mOS of 15 evaluable patients was 5.7 (95%CI: 4.2–9.8) months. All 22 patients had measurable disease at baseline. Median PFS of 14 evaluable patients receiving bevacizumab+TRC105 was 1.8 months (95%CI 1.2–2.1). Serum TRC105 was measurable above target concentration of 25 ug/mL in all evaluable patients. Study medications were well-tolerated in both cohorts. Combined administration did not potentiate known toxicities of either medication, with cerebral hemorrhage not observed.

Conclusions
Single-agent TRC105 lacks activity in bevacizumab-refractory GBM, possibly secondary to upregulated VEGF-A expression. Meaningful mOS in bevacizumab+TRC105 cohort warrants further trials to investigate efficacy of combination therapy.
On design of power sharing for VSC‐based islanded AC microgrids: An adaptive MIMO controller equipped with a predictor
Authors: Ahmadi Farahnaz , Batmani Yazdan , Bevrani Hassan 
Published: September 2023

AbstractIn an AC microgrid, the active/reactive power is usually shared among its distributed generators (DGs) based on the frequency‐active power () droop and the voltage‐reactive power () droop. By increasing the resistant/inductance ratio () of feeder lines; however, adverse effects of interactions between these two control loops are intensified. In this paper, an adaptive multi‐input multi‐output (MIMO) current control structure is proposed to tackle this problem in AC microgrids with arbitrary numbers of DGs in the primary control level. A deep analysis based on the relative gain array (RGA) matrix and the diagonal dominance concept is provided to systematically design MIMO controllers. The proposed technique is based on the Lyapunov's stability theory, and the asymptotic stability of the whole microgrid is guaranteed. For each DG, the suggested design procedure is started by defining a model reference in which the desired control objectives, including the settling time and the steady‐state error, are considered. Then, a feedback‐feedforward controller is established where its gains are adaptively tuned by some rules derived from a Lyapunov function. Moreover, a predictor is used to estimate the adverse effects of other DGs which are taken into account as external disturbances during the design process of the adaptive controller. By considering some realistic scenarios through time‐domain simulations in MATLAB/SIMULINK, it is shown that the proposed strategy can be successfully used to solve the power sharing problem in AC microgrids.
The Congenital Cardiology Cloud – optimizing long-term care
by connecting ambulatory and hospital medical attendance via
telemedicine
Authors: Rottermann Kathrin , Doll Ulrike , Pfenning Simon , Reichenbach Marc , Fey Dietmar , Dobler Alexander , Siauw Céline , Reif Fabian , Gnibl Julia , Cesnjevar Robert , Dittrich Sven 
Published: September 2023

Abstract
Background Patients with complex congenital heart disease frequently
undergo a life-long ambulatory therapy with the need for repeated hospital
interventions. To optimize this manifold interplay, we designed and implemented
a tele-medical service, the Congenital Cardiology Cloud (CCC). This study aims
to analyse the requirements for its implementation through the comprehensive
assessment of design, installation and impact on patient´s care.
Methods CCC’s development comprised the analysis of historically
raised admission and discharge management and the definition of technical and
organizational requirements. Elaboration of procedural flow charts, description
of data formats and technical processes as well as distribution of patient
structure formed part of this process.
Results Analysis of existing workflows uncovered a need for the rebuilding
of admission and discharge process and decision making for further treatment.
The CCC reduces conference-meetings in general and repetitive meetings up to
less than a third. Real-time dispatch of discharge documents guarantees an
instantaneous access to patient-related data. Comparative analyses show a more
complex patient group to be involved in tele-medical services.
Conclusions The CCC enables the sharing of complex clinical information by
overcoming sectoral barriers and improves mutual patient advice. Implementation
of a tele-medical network requires willingness, perseverance and professional
engagement. Future application analysis and possible introduction of refinancing
concepts will show its long-term feasibility.
New Route to Direct Synthesis of Symmetrical Ureas from Carboxylic Acids
Authors: Pujol M. Dolors , Jahani Daniel , Yassine Hasna , Khouili Mostafa 
Published: September 2023

AbstractThe first method for the direct conversion of carboxylic acids into ureas has been developed. The classical procedures described for the formation of ureas from carboxylic acids require two steps, preparation of the isocyanate followed by its aminolysis. In this work, aryl carboxylic and arylalkyl carboxylic acids have been transformed into symmetric ureas in a single step using DPPA or sodium azide as nitrogen source. The addition of water (method A) or the presence of solvent water (method B) was essential for the formation of symmetrical ureas from the corresponding carboxylic acids. The corresponding ureas have been obtained in good to excellent yields of 46 to 100%. This procedure is compatible with different substituents present in the starting carboxylic acid.
Combined Aerobic and Strength Training Improves Dynamic Stability and can Prevent against Static Stability Decline in Postmenopausal Women: A Randomized Clinical Trial
Authors: Marques Ana Claudia Fortaleza , Rossi Fabrício Eduardo , Neves Lucas Melo , Diniz Tiego Aparecido , Messias Iracimara de Anchieta , Barela José A. , Horak Fay B. , Júnior Ismael Forte Freitas 
Published: September 2023

Abstract
Objective To analyze the effect of combined training (CT) in postural control and gait parameters in postmenopausal women.
Methods A parallel-group, randomized, control study was conducted with 16 weeks of combined training (n = 16) versus a non-training control group (n = 12) in postmenopausal women (aged 59.3 ± 8.0). Pre and postintervention assessments included postural control (using an AMTI force platform – Advanced Mechanical Technology, Inc., Watertown, MA, USA) and gait impairments (using baropodometry). In addition, the upper limb strength and abdominal tests, as well as aerobic capacity, assessed functional indicators.
Results The CT intervention in postmenopausal women resulted in improved gait (stride length (p = 0.006); speed (p = 0.013); double support time (p = 0.045); and improved postural control (displacement area of postural sway in a normal base of support with eyes open (p = 0.006). Combined training increased functional indicators (abdominal - p = 0.031; aerobic capacity - p = 0.002).
Conclusion In conclusion, combined aerobic plus strength training effectively improved gait and balance control in older women. The postmenopausal women from the CT group walked faster and with bigger steps after the intervention than the control group. In addition, they presented decreased postural sway in standing and decreased the percentage of double support time while walking, which means improved static and dynamic balance control and functional indicators.
Not Just hydrocarbons: Japan’s multifaceted foreign policy approaches towards the GCC states
Authors: Matsuda Kazuto , Kozhanov Nikolay 
Published: September 2023

AbstractThis paper argues that in spite of the prevailing belief that the relations between Japan and the GCC states are primarily driven by the hydrocarbon trade, the Japanese authorities’ efforts to strengthen their ties with the GCC states are determined by a more complex set of factors. These include not only Japan’s energy security, but also its non-energy economic interests and geostrategic factors. The study thus demonstrates the salience of a multi-sectoral analytical approach, going beyond the traditional hydrocarbon trade, to grasp the full complexity of the increasingly multifaceted ties between Japan and the GCC states.
Proof of concept for measuring growth of shelf marine calcifiers: ‘a Bryozoan odyssey’
Authors: Achilleos Katerina , Smith Abigail M. 
Published: September 2023

Context The variation observed in growth rate estimates of bryozoans raise questions regarding the validity of the methods used to measure growth in these animals. Naturally, the best way for measuring growth rate is to understand the growth in situ, but access is not always straightforward. Aims This study assesses a field experiment for measuring in situ growth of heavily calcified bryozoans in the open ocean at 56 m, the deepest such deployment attempted for bryozoans. Methods Cellaria immersa colonies were collected by dredge from the continental shelf off Otago, marked using calcein, mounted on a purpose-built frame, called ‘Odyssey’, and returned to the shelf for 3 months in the Austral summer (November–February). Key results Data from 10 internodes indicated that growth was, on average, 0.97 ± 0.84 mm year−1 and showed some interesting intracolonial growth patterns. Conclusions and implications The data obtained from this study are only indicative at this stage, but we have succeeded in developing a reproducible experimental set-up for in situ growth experiments of shelf bryozoans, enabling us to record growth, lifespan, and calcification rates of heavily calcified and ecologically important species. Understanding such key species is critical to identifying their role in the ecosystem and providing valuable information for future conservation initiatives.
Request strategies
Authors: Jauhari Edy , Handayani Dwi 
Published: September 2023

Abstract
This research investigates request strategies in the Javanese community and the influence of the ± Power (±P), ±
social Distance (±D), and ± Rank of imposition (±R) on the use of request strategies. The data were collected through Discourse
Completion Tasks (DCTs) and analyzed according to Blum-Kulka et al. (1989). The results
show that in the (+P+D+R) context, requests tend to be expressed indirectly. This is influenced by the (+) which is attached to
all the variables. In the (−P−D−R) context, requests tend to be expressed directly. This is influenced by the (−) which is
attached to all the variables. In the contexts of (+P+D−R), (+P−D+R), (−P−D+R), and (−P+D+R), there is a tug-of-war between the
(+) and (−). However, the influence of the (+) appears to be stronger than the (−). Therefore, in these contexts requests are more
likely to be expressed indirectly rather than directly.
The function of names
Authors: Lee Duck-Young , Ogi Naomi 
Published: September 2023

Abstract
The current study investigates the use of a person’s name
in Japanese and Korean. A name is the first appellation given to an
individual, and functions not only to identify and address them, but also to
establish and maintain everyday interactions. In many languages, a name can
typically be either a given name or family name only, or both in full, and
each form of a name (i.e., given name, family name or full name) may
function differently from language to language. The current study aims to
explore the differences between Japanese and Korean in terms of the
distribution of different forms of names, and the social functions and
pragmatic effects of these forms. Based on the analysis of three Japanese TV
drama series and their Korean remake versions, the study shows that, in
terms of frequency, Japanese can be characterised as a “family name”
language whereas Korean can be characterised as a “full name” language. The
study also demonstrates that there are differences in the use of family
names and full names between the two languages.
Differences in the forms of address between standard Hungary Hungarian
and Slovakia Hungarian
Authors: Vančo Ildikó , Kozmács István 
Published: September 2023

Abstract
It is a documented fact that the Hungarian varieties
spoken outside of Hungary exhibit differences from standard Hungary
Hungarian at all levels of the language system (c.f. Lanstyák 2000). However there is little data on how
address forms have changed where Hungarian is spoken outside of Hungary.
According to Domonkosi
(2002: 146), 16 basic address variants can be distinguished with
combinations of personal suffixes of the verb, pronouns and nominal address
forms, but the data refer only to Hungarian speakers in Hungary. Our study
is the first attempt to compare the address forms used by the respondents of
Hungary Hungarians and Hungarian minorities living outside the borders of
Hungary. The results suggest significant differences between the language
use of the two groups in the use of V and T forms, in the use of the
auxiliary verb
tetszik
, and in the use of
address avoidance.
Investigating address in regional varieties of Italian
Authors: Bresin Agnese 
Published: September 2023

Abstract
In the context of great linguistic diversity
characterising Italy, the case of singular V pronouns is a prime example of
regional variation. Surprisingly, an updated and geographically
comprehensive account – after Rohlfs’s
study (1968) – is missing. This chapter contrasts the
methodologies employed in two relevant studies, namely the LinCi project
(Nesi & Poggi Salani
2013), and Bresin (2021).
Common methodological issues are: comparability of data from the various
research sites, authenticity of data, and generalisability of findings
(connected to representativeness of samples). However, geographical
comprehensiveness emerges as the most compelling methodological challenge in
the Italian context. This chapter outlines the basic characteristics of an
ideal methodology that would produce a geographically comprehensive account
of address in Italian.