bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive associations between mean ambient temperature and involuntary admissions to psychiatric facilities
Authors: Joore Noah L. , van der Horst Marte Z. , Noorthoorn Eric O. , Strous Jurriaan F.M. , Vruwink Fleur J. , Guloksuz Sinan , Siegmund Peter C. , Luykx Jurjen J. 
Published: January 2025

Abstract

Background
Temperature increases in the context of climate change affect numerous mental health outcomes. One such relevant outcome is involuntary admissions as these often relate to severe (life)threatening psychiatric conditions. Due to a shortage of studies into this topic, relationships between mean ambient temperature and involuntary admissions have remained largely elusive.

Aims
To examine associations between involuntary admissions to psychiatric institutions and various meteorological variables.

Methods
Involuntary admissions data from 23 psychiatric institutions in the Netherlands were linked to meteorological data from their respective weather stations. Generalized additive models were used, integrating a restricted maximum likelihood method and thin plate regression splines to preserve generalizability and minimize the risk of overfitting. We thus conducted univariable, seasonally stratified, multivariable, and lagged analyses.

Results
A total of 13,746 involuntary admissions were included over 21,549 days. In univariable and multivariable models, we found significant positive associations with involuntary admissions for ambient temperature and windspeed, with projected increases of up to 0.94% in involuntary admissions per degree Celsius temperature elevation. In the univariable analyses using all data, the strongest associations in terms of significance and explained variance were found for mean ambient temperature (p = 2.5 × 10−6, Variance Explained [r2] = 0.096%) and maximum ambient temperature (p = 8.65 × 10−4, r2 = 0.072%). We did not find evidence that the lagged associations explain the associations for ambient temperature better than the direct associations.

Conclusion
Mean ambient temperature is consistently but weakly associated with involuntary psychiatric admissions. Our findings set the stage for further epidemiological and mechanistic studies into this topic, as well as for modeling studies examining future involuntary psychiatric admissions.
Use of psychedelic treatments in psychiatric clinical practice: an EPA policy paper
Authors: Destoop M. , Mohr P. , Butlen F. , Kéri P. , Samochowiec J. , De Picker L. , Fiorillo A. , Kuypers K.P.C. , Dom G. 
Published: January 2025

Abstract

Background
Recent years show an exponential increased interest (“renaissance”) in the use of psychedelics for the treatment of mental disorders and broader. Some of these treatments, such as psilocybin for depression, are in the process of formal regulation by regulatory bodies in the US (FDA) and Europe (EMA), and as such on the brink of real-world implementation. In the slipstream of these developments increasing commercial initiatives are taking shape. The European Psychiatric Association (EPA) acknowledges both the therapeutic potential of psychedelic substances and the challenges for both research and clinical implementation. Steps need to be taken toward a well-balanced policy based upon sound scientific evidence and research, aiming at safe, ethical responsible integration of psychedelic therapy available for all patients who can potentially benefit.

Methods
In this EPA policy paper, we highlight the potential benefits, and also the challenges of psychedelic treatments, which can be relevant for the future real-world implementation of these treatments.

Results
In addition to an overview of the current evidence and hypotheses of working mechanisms of psychedelic treatment, this policy paper specifically highlights the importance of the psychosocial components of the treatment as well as the ethical and professional aspects playing a role in real-world implementation.

Conclusions
Four recommendations are formulated for further research and clinical implementation.
Development and Validation of a Simplified Financial Toxicity Screening Tool for Use in Clinical Practice
Authors: Thom Bridgette , Tin Amy L. , Chino Fumiko , Vickers Andrew J. , Aviki Emeline M. 
Published: January 2025

PURPOSE
Cancer-related financial toxicity occurs frequently and is a key driver of inequities in access to care and disparities in treatment outcomes. Current practices to screen for financial toxicity are inconsistent because of the lack of a validated and clinically integrated screening tool. This analysis aimed to create and assess an abbreviated version of the validated Comprehensive Score for Financial Toxicity (COST) tool, a measure of financial toxicity used for research purposes, which could easily be added into often-lengthy clinical screening workflows.

METHODS
At an urban comprehensive cancer center with suburban satellite locations, a financial toxicity screening quality improvement project was conducted from June 2022 to August 2023 as part of routine clinical care: 57,526 longitudinal COST surveys were completed by 38,249 patients with cancer. An iterative algorithm selected the items with highest correlation with the total score. Using a separate validation data set, positive and negative predictive values (PPV and NPV, respectively) of the abbreviated tool (two-item) were assessed against the full COST score, with varying risk thresholds.

RESULTS
Inclusion of two COST questions (Q3: “I worry about the financial problems I will have in the future as a result of my illness or treatment”; Q6: “I am satisfied with my current financial situation”) yielded a score that had a correlation of 0.922 with the full instrument score. For the two-item scale, PPV ranged from 74% to 91%, and NPV ranged from 91% to 98% when compared with the full COST tool.

CONCLUSION
This analysis of a large data set finds that a simplified COST tool has high predictive value when compared with the full validated measure. An abbreviated COST measure of two questions is suitable for implementation into clinical screening workflows.
Associations of Financial Hardship and Health Status, Social Functioning, and Mental Health Among Cancer Survivors in the United States: Findings From a Nationally Representative Study
Authors: Chen Min-Hsuan , Zhao Jingxuan , Ogongo Margaret Katana , Han Xuesong , Zheng Zhiyuan , Yabroff K. Robin 
Published: January 2025

PURPOSE
Financial hardship is common among cancer survivors and has been associated with worse physical and mental health in selected subpopulations. We comprehensively examined associations of financial hardship with multiple measures of health status, social functioning, and mental health in a large, nationally representative sample of cancer survivors.

MATERIALS AND METHODS
We identified adults with a cancer history (18-64 years: n = 3,157 and ≥65 years: n = 5,991) from the 2019 to 2021 National Health Interview Survey. Associations of financial hardship and health status, social functioning (eg, difficulty doing errands alone), and mental health (eg, feeling worried, nervous, or anxious) were evaluated with separate multivariable logistic regressions stratified by age group (18-64 and ≥65 years) to reflect differences in employment, health insurance coverage, and underlying health, and adjusted percentages were calculated.

RESULTS

Cancer survivors with financial hardship were more likely to report fair/poor health (18-64 years: 34.7%
v
23.2% and ≥65 years: 40.7%
v
27.3%), social functioning limitations (18-64 years: 10.5%
v
5.3% and ≥65 years: 18.1%
v
11.1%), and work limitations (18-64 years: 36.0%
v
26.2% and ≥65 years: 47.3%
v
33.6%) than their counterparts without financial hardship in adjusted analyses (all
P
< .001). Survivors with financial hardship were also more likely to report frequent anxiety (18-64 years: 47.2%
v
27.8% and ≥65 years: 36.2%
v
16.3%) and depression (18-64 years: 21.7%
v
10.8% and ≥65 years: 19.4%
v
7.3%) than survivors without hardship (all
P
< .001).

CONCLUSION
In this large nationally representative sample, cancer survivors with financial hardship were more likely to report poorer health, social functioning limitations, and worse mental health across multiple measures than their counterparts without hardship. Interventions to screen and connect survivors with relevant services are warranted.
YAP1 Is a Prognostic Marker and Its Inhibition Reduces Tumor Progression in Adrenocortical Tumors
Authors: More Candy C B , Bueno Ana Carolina , Rojas César A O , Stecchini Mônica F , Ramalho Fernando S , Brandalise Silvia R , Cardinalli Izilda A , Yunes José Andres , Junqueira Thais , Scrideli Carlos A , Castro Margaret , Antonini Sonir R R 
Published: January 2025

Abstract

Context
Adrenocortical cancer (ACC) is rare and aggressive, with YAP1 overexpression associated with poor outcomes in pediatric patients.

Objective
In this study, we investigated the mechanisms by which YAP1 drives ACC progression and explored it as a potential target therapy.

Methods
YAP1 expression and methylation in ACC were analyzed from pediatric and adult cohorts. The role of YAP1 on ACC progression was examined in vitro using an adrenocortical cell line. Also, was evaluated the YAP1's influence on β-catenin. The effect of YAP1 pharmacological inhibition was assessed on tumor growth in a murine xenograft model of ACC.

Results
High YAP1 expression was associated with lower survival in all cohorts. The YAP1 methylation signature was associated with patients’ prognosis. Inhibition of YAP1 reduced ACC cell viability through cell cycle arrest in the G0/G1 phase, and inhibited the epithelial–mesenchymal transition and cell invasion. YAP1 modulated β-catenin protein levels and transcription activity, whereas β-catenin partially mediated the effect of YAP1 on adrenocortical tumorigenesis. In vivo, verteporfin impaired tumor growth and Ki67 immunoreactivity in xenografts.

Conclusion
YAP1 is a potential novel prognostic marker in patients with ACC. Its deregulation contributes to adrenocortical tumorigenesis partially through crosstalk between Hippo/YAP1 and Wnt/β-catenin pathways. YAP1 inhibition is a new antitumor target.
Role of Sulcal Hyperintensity and Web/Net Appearance on MRI in Patients With Chronic Subdural Hematoma Presenting With Transient Neurological Deficits
Authors: Kato Takenori , Hasegawa Toshinori , Mizuno Akihiro , Kuwabara Kyoko , Ohno Masasuke , Kuramitsu Shunichiro , Naito Takehiro , Kageyama Akinori , Niwa Hirotaka , Oishi Hiroyuki 
Published: January 2025

BACKGROUND AND OBJECTIVES:
Transient neurological deficits (TNDs) in patients with chronic subdural hematoma (CSDH), such as fluctuating aphasia, hemiparesis, or sensory disturbances, present diagnostic and treatment challenges as their pathophysiology remains unclear. The aim of this study was to investigate the association between specific MRI findings and TNDs in patients with CSDH and explored their relationship through intraoperative observation.

METHODS:
We retrospectively evaluated 72 patients with CSDH who underwent preoperative MRI among 251 CSDH patients treated from January 2020 to December 2023. Sulcal hyperintensity (SHI) on fluid-attenuated inversion recovery images and web/net appearance (W/N) on T2*-weighted images were assessed and their association with TNDs was analyzed. Flexible neuroendoscopic surgery (FNS) was performed on 8 patients with TNDs exhibiting these MRI findings, allowing intraoperative observation of intrahematoma conditions. Histopathological examination was performed on hematoma samples.

RESULTS:
Thirteen patients (5.2%) presented with preoperative TNDs. Diffuse SHI and W/N were strongly associated with preoperative TNDs (odds ratio = 150.0, P < .001). FNS revealed organized hematomas with inflammatory changes corresponding to the SHI and W/N seen on MRI. Patients who underwent FNS experienced complete resolution of TNDs postprocedure, with diffuse SHI disappearing by one month. No recurrence was observed at a mean follow-up of 5.9 months.

CONCLUSION:
This study provided the first evidence that the combination of diffuse SHI and W/N on MRI strongly correlates with TNDs in patients with CSDH, serving as valuable diagnostic indicators. These findings will aid in guiding surgical approach selection and facilitate more personalized treatment strategies for patients with CSDH presenting with TNDs.
Sox10 is required for systemic initiation of bone mineralization
Authors: Gjorcheska Stefani , Paudel Sandhya , McLeod Sarah , Paulding David , Snape Louisa , Sosa Karen Camargo , Duan Cunming , Kelsh Robert , Barske Lindsey 
Published: January 2025

ABSTRACT
Heterozygous variants in SOX10 cause congenital syndromes affecting pigmentation, digestion, hearing, and neural development, primarily attributable to failed differentiation or loss of non-skeletal neural crest derivatives. We report here an additional, previously undescribed requirement for Sox10 in bone mineralization. Neither crest- nor mesoderm-derived bones initiate mineralization on time in zebrafish sox10 mutants, despite normal osteoblast differentiation and matrix production. Mutants are deficient in the Trpv6+ ionocytes that take up calcium from the environment, resulting in severe calcium deficiency. As these ionocytes derive from ectoderm, not crest, we hypothesized that the primary defect resides in a separate organ that systemically regulates ionocyte numbers. RNA sequencing revealed significantly elevated stanniocalcin (Stc1a), an anti-hypercalcemic hormone, in sox10 mutants. Stc1a inhibits calcium uptake in fish by repressing trpv6 expression and Trpv6+ ionocyte proliferation. Epistasis assays confirm excess Stc1a as the proximate cause of the calcium deficit. The pronephros-derived glands that synthesize Stc1a interact with sox10+ cells, but these cells are missing in mutants. We conclude that sox10+ crest-derived cells non-autonomously limit Stc1a production to allow the inaugural wave of calcium uptake necessary to initiate bone mineralization.
Radiofrequency thermocoagulation of Gasserian ganglion in trigeminal neuralgia
Authors: Rulewska Natalia Maria , Grabowski Filip , Neska Dagmara , Siemko Jakub , Prystacka-Szar Dominika , Stadler-Szajda Justyna , Czyżnikiewicz Adrianna , Stołowski Wenancjusz , Bujak Magdalena , Waśniowska Magdalena , Chodkowski Jakub 
Published: January 2025

Introduction: Trigeminal neuralgia (TN) is a form of neuropathic pain that targets the fifth cranial nerve, leading to intense facial pain that can significantly impact one’s quality of life. This condition typically manifests as recurring episodes of sharp, unilateral pain along one or more branches of the trigeminal nerve.The exact mechanism of trigeminal neuralgia remains largely unknown. Most pain attacks are triggered by certain stimuli in the areas served by the trigeminal nerve. One possible treatment approach for trigeminal neuralgia is radiofrequency thermocoagulation.
Aim: The aim of this article is to explore the underlying mechanisms of trigeminal neuralgia and assess the effectiveness of treating it through radiofrequency thermocoagulation of the Gasserian ganglion.
Review methods: A comprehensive analysis of research papers available on PubMed and Google Scholar was undertaken using the searchterms encompassing the following keywords: trigeminal neuralgia / Gasserian ganglion radiofrequency thermal therapy/ radiofrequency thermal coagulation/ radiofrequency trigeminal rhizotomy/ trigeminal neuralgia mechanism.
Conclusion: The exact mechanisms behind trigeminal neuralgia are still unclear, but several theories suggest that factors such as inflammation, ion channel dysfunction, neuroinflammatory conditions, or bioresonance issues may be involved. Radiofrequency Thermocoagulation (RFT) has proven to be an effective option for easing pain in individuals suffering from Trigeminal Neuralgia. Research indicates that RFT not only significantly reduces pain initially but also provides a prolonged period of relief post-procedure. The temperature achieved during radiofrequency treatments is a key factor in determining the effectiveness of RFT.
Detecting Multiple Changepoints by Exploiting Their Spatiotemporal Correlations: A Bayesian Hierarchical Approach
Authors: Chen Xian , Huang Kun , Wu Weichi , Jiang Hai 
Published: January 2025

Capturing the nonstationarity of spatiotemporal data over time via changepoints has received increasing attention in various research fields. Although extensive studies have been conducted to investigate changepoint detection with spatiotemporal data, research on detecting multiple clusters of spatiotemporally correlated changepoints has remained unexplored. In this paper, we propose a multilayer Bayesian hierarchical model: The first layer uncovers the spatiotemporal correlations of changepoints based on multiple propagation binary variables, which describe the occurrences of change propagations. The second and third layers compose nonhomogeneous hidden Markov models to capture time series data and their state sequences, in which changes of states signify changepoints. We perform Bayesian inference for changepoints and change propagations via a forward-backward algorithm that combines recursion and Gibbs sampling. Based on the experiments with simulated data, we show that our method significantly improves the detection accuracy toward spatiotemporally correlated changepoints. A real-world application to bike-sharing data also demonstrates the effectiveness of our method. This research has significant relevance to companies operating systems across geographical regions, as it enables a more robust understanding of emerging trends and shifts in spatiotemporal data. Funding: Financial support from the National Natural Science Foundation of China [Grants 12271287, 72361137005, and 72401177] is gratefully acknowledged. Supplemental Material: The online appendix is available at https://doi.org/10.1287/ijds.2024.0030 .
Growth performance and starch yield potential of arrowroot (Maranta arundinacea) from various locations in Thailand
Authors: IEAMKHENG SUPAPORN , SANTIBENCHAKUL SOMTOP , POONPAERDCHON SUPATTRA , SOEM BUNNY , SOOKSAWAT NAJJAPAK 
Published: January 2025

Abstract. Ieamkheng S, Santibenchakul S, Poonpaerdchon S, Soem B, Sooksawat N. 2024. Growth performance and starch yield potential of arrowroot (Maranta arundinacea) from various locations in Thailand. Biodiversitas 25: 3750-3757. Arrowroot (Maranta arundinacea L.) is a tuberous type of medicinal that has high starch quality and good health benefits. This research studied the yield and growth characteristics of arrowroot samples from different 5 accessions in Thailand, along with their important properties for commercial use. Samples were collected from 5 field crops in Thailand: Tha Maka District, Kanchanaburi Province (Th-T-K); Sai Yok District, Kanchanaburi Province (Th-Sy-K); Ratchaburi Province (Th-RB); Chanthaburi Province (Th-Chan), and Sa Kaeo Province (Th-SK). The growth rate and yield of Thai arrowroot at 3, 6, and 9 months after planting were evaluated and the starch was extracted and characterized. During 3 months, there was only growth with no tuber yield; at 6 months, the arrowroot from Th-Sy-K had the highest growth rate and yield. The highest yields were at 9 months after planting, with the tuber weight per clump in the range of 596-2,980 g that produced 121.8-150.8 g of starch (8-10% yield). DNA fingerprinting analysis and the molecular study indicated no variation among the 5 accessions of arrowroot, indicating the uniformity and reliability of the samples. The results of the nutritional composition, the amounts of carbohydrates and amylose in the Th-Sy-K and Th-RB samples tended to increase with plant growth. At the same time, other contents, namely moisture, and lipid, decreased. The main component of the arrowroot starch was carbohydrate (87-91%), and the 9-month starch had high viscosity and heat-resistant values. In conclusion, arrowroot starch showed potential as a novel raw material for application in the food industry and possibly in cosmetic and pharmaceutical manufacturing.
Diversity of flora and fauna in various forest ecosystem types of South Sorong District, Southwest Papua Province, Indonesia
Authors: LENSE OBED N. , WANMA JIMMY F. , KESAULIJA FRANCINA F. , MANSYUR FADHILAH I. , RACHIM ARMANSYAH K. , KREY KELIOPAS , WANMA BEATRIX , KESAULIJA REYNOLD , SIMANJORANG DINOSIUS , SIMBIAK FIKTOR 
Published: January 2025

Abstract. Lense ON, Wanma JF, Kesaulija FF, Mansyur FI, Rachim AK, Krey K, Wanma B, Kesaulija R, Simanjorang D, Simbiak F. 2024. Diversity of flora and fauna in various forest ecosystem types of South Sorong District, Southwest Papua Province, Indonesia. Biodiversitas 25: 3884-3898. The distribution of unspoiled natural conditions, uniqueness, and high biodiversity are not limited to conservation areas but also to production and protected forest areas and other land use areas in Southwest Papua Province, Indonesia. These forest ecosystems have high flora, fauna, and areas that are priority animal pockets whose home ranges reach and enter essential ecosystem areas. However, the need for such diverse information has been an issue in this region. Hence, a diversity study of vegetation, mammals, birds, reptiles, amphibians, and butterflies in various ecosystem types is needed. The six types of ecosystems, namely the alluvial lowland forest of Nakna, the lowland karst forest of Boldon, the lowland limestone forest of Wara, the alluvial swamp forest of Konda, the peat swamp forest of Nakna, and the mangrove forest of Konda, were targeted. The line-plotted method was used for vegetation. Direct observation on a 1,500 m line transect, the point count method, and the Visual Encounter Survey were employed to collect data from mammals, birds, reptiles, amphibians, and butterflies. Results indicated that the lowland limestone forest of Nakna and the lowland karst forest of Boldon consisted of the highest number of trees (532 and 373 trees ha-1, respectively), species (56 and 52 species ha-1, respectively) per unit area. Unique and endemic orchid species, including Dendrobium transversilobum J.J.Sm. and Bulbophyllum septemtrionale (J.J.Sm.) J.J.Sm., also exist in this region, adding to the wonder of the region's biodiversity. The research also discovered a total of 9 species of mammals, 52 species from 25 families of birds, 39 species of reptiles and amphibians, of which species Litoria sanguinolenta (Van Kampen, 1909) is a new record to the region and 58 species of day butterflies from the Papilonoidea superfamily. Several key species of flora and fauna in this region require special attention as they are in alert status, which may require intervention to maintain their existence in nature so that they do not disappear or even become extinct.