bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of pain treatment for patients with mine-blast wounds depending on the number of localizations in military mobile hospitals
Authors: Horoshko V.R. , Kuchyn Iu.L. 
Published: August 2023

Patients with gunshot wounds suffer from chronic pain in 70% of cases, and those with mine-blast wounds – in 83.3% of cases. Civilian patients, after serious injuries, in 11-40% of cases. Unfortunately, there is not enough data to study the causes of such a high frequency of pain chronicity. Therefore, the study of the results of pain treatment at the stage of treatment in military mobile hospitals may be able to reveal the reasons for such a high frequency of chronicity.
Methods. The treatment of 280 patients with mine-blast wounds was analyzed. The intensity of pain was diagnosed using a visual analog scale. The Shapiro-Wilk test was used to check the distribution of quantitative indicators for normality. The law of distribution differed from the normal one, the median value (Me) and interquartile range (QI-QIII) were given to present quantitative indicators, and the comparison of indicators in the two groups was performed by the Mann-Whitney test. To analyze the dynamics of indicators, the Friedman criterion for linked samples was used, and the posterior comparison was performed using the Bonferroni correction. For qualitative indicators, the absolute frequency of the trait and the relative frequency (%) are presented, and the chi-square test with the correction for continuity was used to compare the two groups. In all cases, the critical level of significance was set at 0.05.
Results. The analysis of pain intensity according to the VAS, before anesthesia, upon admission to military mobile hospitals, showed that patients experienced high-intensity pain reaching 7 points. This indicates a lack of effective pain control both at the initial stage of treatment and during evacuation. After anesthesia, VAS data indicate the presence of moderate pain – 4 points. The intervals between analgesic treatments averaged 6 hours. Although the effectiveness of analgesia according to VAS was low.
Conclusions. Patients with mine-blast injuries have a very high risk of chronic pain – 57.5% higher than in injured patients in civilian life. The study results point to ways to improve treatment outcomes for this category of patients. Achieving high-quality pain control at the stage of treatment in military mobile hospitals and maintaining the continuity of treatment during an evacuation can potentially reduce the incidence of pain chronicity.
ARTERIAL HYPERTENSION AMONG MEDICAL WORKERS. ANALYSIS. EVALUATION
Authors: Tolstanov О. K. , Gordienko L. M. 
Published: August 2023

The aim. To examine the impact of individual medical and social factors, including work experience, lifestyle and living conditions, excess body weight, metabolic syndrome, types of circadian rhythms of blood pressure, and heredity, on the frequency of arterial hypertension (hypertensive disease - HD) formation.
Materials and methods. The study involved the collection of anamnestic data, conducting interviews, performing objective examinations, and monitoring blood pressure in 391 medical workers, predominantly from therapeutic, surgical, and intensive care backgrounds. The obtained data were statistically processed using probability assessment criteria, risks assessed through odds ratio (OR), and ROC analysis.
The results. The study revealed that only 33% of medical workers have a normal body weight. The risk of developing hypertensive disease (HD) is 3.24 times higher in the group with excess body weight and 8.72 times higher in the group with obesity compared to the examined subjects with normal body weight (p<0.0001). Daily blood pressure monitoring results showed a statistically significant difference in 12 out of the 21 studied parameters (p<0.05) between patients with HD, with and without metabolic syndrome. This indicates that the presence of metabolic syndrome affects the severity of hypertensive disease. Additionally, a statistically significant difference (p<0.05) was observed in the distribution of circadian rhythm types of blood pressure between groups with and without hypertension. It was established that there is a predominance of unfavorable types of circadian blood pressure rhythm in medical worker groups experiencing high professional psycho-emotional stress (78.1-85.5%). Recognizing the risk factors for HD occurrence in medical workers can significantly enhance the effectiveness of a comprehensive hypertensive disease prevention program, leading to reduced blood pressure levels and a lower frequency of complications.
Conclusions. It has been established that excess body weight is a risk factor for the development of hypertensive disease (HD) in medical personnel. The presence of metabolic syndrome has been proven to affect the severity of the hypertensive disease course. There is a certain association between disruptions in circadian blood pressure rhythms, professional psycho-emotional stress, and the development of arterial hypertension in medical workers of certain specialties. The prognostically significant threshold level of work experience for the formation of a group at an increased risk of developing HD is 11 years.
CLINICAL AND LABORATORY FEATURES OF THE COURSE OF CHRONIC VIRAL HEPATITIS B AND C IN CHILDREN OF PODILSKY REGION: POSSIBILITY FOR MODERN MONITORING
Authors: Nezgoda I. , Demchyshyn Y. 
Published: August 2023

Introduction. In modern hepatology, a special place is occupied by chronic viral hepatitis, including B and C, because today they occupy the leading positions due to their high prevalence, the possibility of severe complications, and also they could lead to death in both adults and children. Specialists should have a comprehensive understanding of the clinical course and laboratory diagnosis of viral hepatitis to facilitate timely diagnosis and effective management of this condition.
The aim: to evaluate the clinical and laboratory features of the course of chronic viral hepatitis B and C in children by determining patterns between parametric indexes characterizing the processes of liver fibrosis.
Materials and methods. In the process of scientific research, 49 children were examined, including 29 children with diagnosed chronic viral hepatitis B and C (group I) and 20 almost healthy children (group II). The diagnoses of CHB and CHC were confirmed by the PCR method and specific markers detected by ELISA. All examined patients underwent anamnesis collection, general clinical examination, laboratory examination, calculation of CDS, Lok, GUCI, APRI, FIB-4 and "Fibrotest" diagnostic indexes. Statistical data analysis was carried out with "R-Studio" and "Statistica 10.0" software, using the methods of descriptive statistics, correlation analysis. Significance was considered significant at p<0.05. The study was conducted in compliance with the principles of the Declaration of Helsinki.
Results. It was established that the levels of ALT, AST, GGT, ALP, indirect bilirubin, international normalized ratio (INR) were significantly higher in the examined patients of the I group. The level of the CDS index was significantly higher in the examined patients of the I group (5,97±0,30), compared with the patients of the II group (4,35±0,28) (p<0,001). A similar trend was noted with the Lok index and FIB-4 (p<0,001). The GUCI and APRI indices were significantly higher in patients of the I group (1,02±0,22; 0,73±0,04), compared to the examined patients of the II group (0,27±0,02; 0,23±0,02) (p<0,01).
Conclusions. Implementation of non-invasive indices into clinical practice for the management of children with chronic hepatitis B and C will allow for dynamic monitoring of liver fibrogenesis processes.
Hemorheological changes in arterial hypertension in persons with and without COVID-19
Authors: Muravyov A.V. , Priezzhev A.V. , Tikhomirova I.A. , Lugovtsov A.E. , Mikhailov P.V. 
Published: August 2023

BACKGROUND: Vascular resistance, and therefore blood pressure (BP), depends on vascular and rheological factors. Microrheological characteristics of red blood cells (RBCs) can affect blood viscosity (BV) and thus be included in the pathogenesis of increased blood pressure in arterial hypertension (AH). Signaling molecules such as gasotransmitters (NO, CO and H2S) regulate vascular tone and RBC microrheological characteristics and thus affect blood pressure and tissue perfusion. OBJECTIVE: It was evaluated the changes in the macro- and microrheological characteristics of blood and red blood cells (RBCs) under arterial hypertension in persons with and without COVID-19, as well as the protective effect of NO and H2S donors on the RBC microrheological properties. METHODS: Hemorheological profile parameters were recorded in group 1 individuals ( n = 18, 9 women and 9 men) without a history of COVID-19; group 2 ( n = 16; 11 females and 5 males), hypertensive patients who had COVID-19. As a control, there was a group of healthy individuals (group 3 n = 22). In experiments with red blood cells (RBCs) and their recovered ghosts (filled with an isotonic solution of known viscosity), deformability (RBCD) and aggregation (RBCA) were recorded after incubation of cells with sodium nitroprusside (SNP, 100μM) and sodium hydrosulfide (NaHS, 100μM). RESULTS: In patients with AH in both groups, the main parameters of the hemorheological profile were negatively changed, including a decrease in RBCD and an increase in BV, plasma viscosity (PV) and RBCA. SNP and NaHS significantly increased deformability and reduced their aggregation ( p < 0.01). However, in healthy individuals, microrheological responses to GT donors (100μM) were more pronounced than in patients with AH, especially in the AH+COVID-19 group ( p < 0.05). CONCLUSION: Both gasotransmitter donors (NO and H2S) have a positive effect on the RBC microrheological characteristics in healthy and sick individuals. However in hypertensive patients, especially those who had COVID-19, microrheological responses to GT donors were significantly lower. Therefore, on the model of red cell microrheological responses, as on a test object, it is possible to determine the decrease in the sensitivity of cells and tissues to the regulatory action of gasotransmitters.
The risk factors for coagulation disorder of chimeric antigen receptor-T cell therapy in patients with hematological tumors: A systematic review and meta-analysis
Authors: Xia Yunqing , Tang Liang , Hu Yu 
Published: August 2023

BACKGROUND: Currently, the frequency of coagulation dysfunction associated with chimeric antigen receptor-T cell (Car-T) therapy cannot yet be determined. OBJECTIVE: We performed a systematic review and meta-analysis to examine the prevalence of abnormal laboratory tests related to coagulation disorders in patients receiving Car-T therapy and provide a reference for future risk assessment mechanisms. METHODS: We searched PubMed, Embase, and Web of Science for relevant studies and evaluated their quality using the methodology index of non-random research (MINORS). 2672 quotations were retrieved via systematic searches. After screening of titles, abstracts and full-text, 45 trials involving 2541 patients were ultimately included. 41 studies reported the incidence of thrombocytopenia, 8 studies reported the rate of low fibrin, 4 trials reported the rate of APTT or PT abnormalities and only 3 trials reported the incidence of venous thromboembolism (VTE). We performed a quantitative meta-analysis to explore the incidence of thrombocytopenia following Car-T treatment. The incidence of hypofibrinogenemia, VTE, and abnormal APTT or PT was only qualitatively assessed, as fewer reports were included in this study. RESULTS: The overall incidence of thrombocytopenia associated with Car-T therapy was 45.8% (95%[CI], 0.384–0.533). The highest rates of thrombocytopenia occurred in patients with multiple myeloma (60.1%, 95%[CI], 0.507–0.688) and aged between 18 to 60 (50%, 95%[CI], 0.367–0.633). There was greater prevalence of thrombocytopenia in BCMA-Car-T therapy of 58.7% (95%[CI], 0.482–0.685). Thrombocytopenia occurred most frequently in Car-T patients treated with a dosage of 1 × 105–1 × 106 cell/kg, at a rate of 66.2% (95%[CI], 0.561–0.749). CONCLUSION: Overall, 45.8 percent of patients receiving Car-T treatment suffered from thrombocytopenia. Multiple myeloma patients, ages between 18–60, a dose of 1 × 105–1 × 106 cell/kg and BCMA-Car-T therapy are all considered high-risk factors.
Pengaruh Relaksasi Autogenik dalam Menurunkan Kadar Gula Darah pada Pasien DM Tipe II di Desa Kajhu
Authors: Al-Fanshuri Mushawwir , Tharida Maimun 
Published: August 2023

Keberhasilan dalam tatalaksana diabetes mellitus, dapat dicapai dengan pemantauan berkala untuk glukosa darah dan faktor risiko yang akan mungkin terjadi melalui pengajaran perawatan mandiri dan perubahan prilaku. Penatalaksanaan yang lainnya melalui salah satu bentuk latihan jesmani dengan melakukan relaksasi terhadap tubuh, relaksasi yang dapat mengantarkan bagi penderita diabetes lepas dari kecanduan gula serta membuat seluruh hormon yang mengatur sistem tubuh dapat bekerja secara optimalsalah satunya yaitu relaksasi autogenik. Penelitian ini bertujuan untuk mengetahui pengaruh relaksasi autogenik dalam menurunkan kadar glukosa darah pada Pasien DM Tipe II di Desa Kajhu. Metode penelitian ini adalah Quasi experiment dengan one group pretest postest design. Pengumpulan data dilakukan pada tanggal 7 s/d 12 sept 2022. Populasi dalam penelitian ini 15 orang penderita diabetes mellitus dengan teknik pengambilan sampel purposive sampling. Pengumpulan data mengggunakan data primer. Analisis menggunakan pairet t-test. Hasil penelitian menunjukkan ada perubahan kadar gula darah sebelum dan sesudah pemberian intervensi relaksasi autogenik (p=0,001). Dapat ditarik kesimpulan pemberian intervensi relaksasi autogenik efektif terhadap perubahan kadar gula darah sebelum dan sesudah intervensi. Diharapkan hasil penelitian ini dapat dijadikan masukan dalam penentuan program yang akan diambil sebagai upaya peningkatan kesehatan masyarakat kedepannya. Kata kunci: Relaksasi Autogenik, Kadar Gula Darah, Diabetes Melltus Tipe II Successful management of diabetes mellitus can be achieved through regular monitoring of blood glucose and identifying possible risk factors through teaching self-care and behavior change. Another method of management is through physical exercise that involves relaxing the body a relaxation that can free diabetics from sugar addiction and ensure that all hormones that regulate the body system work optimally, one of which is autogenic relaxation.This study aims to determine the effect of autogenic relaxation in reducing blood glucose levels in type II diabetes patients in Kajhu Village. This research method is a quasi-experiment with a one-group pretest-posttest design. Data collection was carried out from sept 7–12, 2022. The population in this study was 15 people with diabetes mellitus, selected using a purposive sampling technique. Data collection using primary data analysis using a paired t-test. The results showed that there were changes in blood sugar levels before and after giving an autogenic relaxation intervention (p = 0.001). It can be concluded that the provision of autogenic relaxation intervention is effective at affecting changes in blood sugar levels before and after intervention. It is hoped that the results of this study can be used as input in determining the program that will be implemented as an effort to improve public health in the future. Keywords : Autogenic Relaxation, Blood Sugar Level, Diabetes Mellitus Type II
Enseñanza de las Ciencias Naturales en la Escuela Secundaria Rural: una mirada del vínculo con el contexto
Authors: Zapata Rocío de los Milagros 
Published: August 2023

Se aborda la enseñanza de las ciencias naturales en escuelas secundarias en contextos de ruralidad, explorando en una muestra de 23 docentes cómo vinculan sus propuestas de enseñanza de las ciencias naturales con el contexto inmediato/no inmediato de una escuela rural. Se analizan documentos presentados por las y los docentes, de los cuales más de la mitad vincula sus propuestas con el contexto, y el resto presenta dificultades o no lo hace directamente. Se concluye la necesidad de ampliar este tipo de investigaciones para conocer y evaluar las necesidades de formación de los docentes de ciencias naturales en estos contextos particulares
Simplifying Complexity: Scenario Reduction Techniques in Stochastic Programming
Authors: Sinaga Christian , Tulus Tulus , Mawengkang Herman 
Published: August 2023

Stochastic programming problems arise as mathematical models for optimizing problems under stochastic uncertainty. Computational approaches for solving these models often involve approximating the underlying probability distribution with a probability measure that has finite support. To mitigate the computational complexity associated with increasing the number of scenarios, it may be necessary to reduce their quantity. The scenario is selected as the first element of supp , and the separable structure is used to determine the second element of supp while keeping the first element fixed. The process is repeated to establish the remaining indices, and each subsequent scenario is reduced accordingly. This iterative process continues until scenario is reduced
Mielomeningocele cervical. Reporte de caso
Authors: Injante-Bustamante Rossie Thais , Dávila-Aliaga Carmen 
Published: August 2023

El mielomeningocele es la forma más frecuente de disrafismo espinal, representa una anomalía congénita del cierre de neuróporo posterior y su localización cervical es poco frecuente. Se presenta el caso clínico de un neonato nacido en el Instituto Materno Perinatal, que presentó mielomeningocele cervical con deterioro neurológico desde el nacimiento y cariotipo con translocación robertsoniana. Es muy importante fortalecer la prevención de disrafismo espinal en la futura madre y gestante; así como la atención integral clínica y quirúrgica que mejore la sobrevida de estos pacientes.
Agronomic and environmental aspects of organo-mineral fertilizers produced with a by-product of the intermediate process of tanning
Authors: Lima Francielle Roberta Dias de , Silva Aline Oliveira , Amorim Helen Carla Santana , Figueredo Eduardo Sobrinho Santos , Carneiro Rafael Marta Carbone , Jara Madeliny Saracho , Carneiro Marco Aurélio Carbone , Guilherme Luiz Roberto Guimarães 
Published: August 2023

IntroductionThe by-product of the intermediate process of tanning (BPIPT) can be used in the manufacturing of environmentally-friendly organo-mineral fertilizers (OMF). However, the presence of potentially toxic elements (e.g., chromium, Cr), can hinder the use of BPIPT in agriculture. This study aimed: i) to evaluate soil chemical and biological properties following the application of fertilizers produced with a BPIPT, in contrast to other OMF produced with traditional organic matrices; and ii) to assess the impacts of such products on wheat growth and nutrition.MethodsSamples (0-0.2 m) of two Oxisols [Red-Yellow Latosol (LVAd) and Red Latosol (LVd)] were used in this study, consisting of two experiments (with five treatments and five replicates) using different OMF, in a sequence: 1) incubation of fertilizers in soil samples for 30 days, and 2) wheat cultivation (30 days) after the fertilizer incubation. The treatments consisted of an arrangement of mineral fertilizers based on nitrogen, phosphorus, and potassium (NPK fertilizers), associated with OMF based on BPIPT (OM-IPT and OM-IPT+S) or commercial manure (OM-CM and OM-CM+S), with or without sulfur (S), and a control treatment. Elemental availability in soils and microbial attributes were determined after the incubation of the OMF in the soils. After wheat cultivation, plant biomass, nutritional composition, β-glucosidase activity, and fluorescein diacetate hydrolysis (FDA) were measured.Results and discussionThe application of BPIPT-derived OMF in the present study increased available Cr fraction contents in both soils. However, OM-IPT caused low soil acidification, enhanced wheat growth and nutrition, and stimulated microbial activity in soils (FDA and β-glucosidase), thus evidencing the agronomic and environmental benefits of this OMF and their potential to contribute to a cleaner, more sustainable agriculture.
Colchicine efficacy comparison at varying time points in the peri-operative period for coronary artery disease: a systematic review and meta-analysis of randomized controlled trials
Authors: Wei Zhi-Yang , Lai Jun-Yu , Li Ya-Ting , Yu Xiao-Yan , Liu Yan-Hong , Hu Jing-Xuan , Gao Bei-Bei , Wu Jian-Guang 
Published: August 2023

ObjectivesOver the years, it has been found that colchicine offers substantial benefits in secondary prevention in patients with coronary artery disease (CAD). We studied the effects of colchicine timing because there are no guidelines about when to provide it during the perioperative period for patients with CAD.MethodsUp to January 1, 2023, seven electronic literature databases were screened (including three English databases and four Chinese databases). Randomized controlled trials included only treatment with colchicine in the perioperative period of CAD. The Cochrane Evaluation Tool was used to judge the risk of bias in research. Statistical analysis was performed by Stata 16.0 software.ResultsWe evaluated twelve studies that found colchicine to be effective in decreasing the occurrence of major adverse cardiac events (MACEs) (p &lt; 0.00001), but it also raised the rate of adverse events (p = 0.001). Subgroup analysis showed the same benefit in lowering the incidence of MACE with continuous administration of a total daily dose of 0.5 mg postoperatively while minimizing drug-related side effects in the patients (p = 0.03). When it comes to preventing surgical stroke occurrences, postoperative administration is more effective (p = 0.006). While the effect of simultaneous preoperative and postoperative administration was marginally greater than other periods in reducing postoperative hs-CRP levels (p = 0.02).ConclusionColchicine, a traditional anti-inflammatory drug, also reduces the risk of MACE by reducing inflammation after PCI. Administration at different periods had no significant effect on decreasing the occurrence of MACE, but when administered postoperatively, we advise continuous administration with a total daily dose of 0.5 mg to obtain the same benefit while minimizing the drug's side effects. Postoperative administration is the better measure to prevent postoperative stroke events. Due to the effective anti-inflammatory effect of colchicine, we recommend its use as early as possible in the perioperative period and its continued use at low doses in the postoperative period.
Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=316751, identifier CRD42022316751.