bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biocompatible and Oxidation‐Resistant Ti3C2Tx MXene with Halogen‐Free Surface Terminations
Authors: Yoon Jaeeun , Kim Seongchan , Park Ki Hong , Lee Seungjun , Kim Seon Joon , Lee Hyojin , Oh Taegon , Koo Chong Min 
Published: March 2023

AbstractSurface chemistry influences not only physicochemical properties but also safety and applications of MXene nanomaterials. Fluorinated Ti3C2Tx MXene, synthesized using conventional HF‐based etchants, raises concerns regarding harmful effects on electronics and toxicity to living organisms. In this study, well‐delaminated halogen‐free Ti3C2Tx flakes are synthesized using NaOH‐based etching solution. The transversal surface plasmon mode of halogen‐free Ti3C2Tx MXene (833 nm) confirmed red‐shift compared to conventional Ti3C2Tx (752 nm), and the halogen‐free Ti3C2Tx MXene has a different density of state by the high proportion of –O and –OH terminations. The synthesized halogen‐free Ti3C2Tx exhibits a lower water contact angle (34.5°) and work function (3.6 eV) than those of fluorinated Ti3C2Tx (49.8° and 4.14 eV, respectively). The synthesized halogen‐free Ti3C2Tx exhibits high biocompatibility with the living cells, as evidenced by no noticeable cytotoxicity, even at very high concentrations (2000 µg mL⁻1), at which fluorinated Ti3C2Tx caused ≈50% reduction in cell viability upon its oxidation. Additionally, the oxidation stability of halogen‐free Ti3C2Tx is enhanced unexpectedly, which cumulatively provides a good rationale for pursuing the halogen‐free routes for synthesizing MXene materials for their uses in biomedical and therapeutic applications.
The convergence dynamics of economic freedom across U.S. states
Authors: Payne James E. , Saunoris James W. , Nazlioglu Saban , Karul Cagin 
Published: March 2023

AbstractThis study tests for convergence in economic freedom across the 50 U.S. states from 1981 to 2019. In particular, we test for stochastic convergence in overall economic freedom using unit root tests that account for structural breaks and bounded processes, two sources of parameter instability. We find limited evidence of stochastic convergence. Further analysis of relative (club) convergence and weakσ‐convergence rejects the presence of overall convergence in the panel of the U.S. states, but the emergence of two convergence clubs with respect to state‐level economic freedom. The logit analysis of the determinants of the convergence clubs reveals that more prosperous states and states with a higher initial level of economic freedom have a higher probability of being in the club with more economic freedom. However, more racially diverse states have a lower probability of being in the club with more economic freedom.
Exploration of new and alternative sources of targeted bioflavonoids using ultra‐performance liquid chromatography‐tandem mass spectrometry
Authors: Singh Yatendra , Rawat Priyanka , Kumar Akhilesh , Singh Sumit K. , Mishra Dipak K. , Kanojiya Sanjeev 
Published: March 2023

AbstractBioflavonoids have exhibited remarkable pharmacological and biological properties. Moreover, many plants rich in flavonoids have been used as natural medicine or functional foods for thousands of years. Here, we introduce a liquid chromatography‐mass spectrometry‐based approach for the exploration of new/alternative sources of targeted bioflavonoids from plants of the Fabaceae family. The approach includes a selection of the plants from the Digital Library of Indian Medicine Plants and their Metabolites database, the literature survey of selected plant species, and a liquid chromatography‐mass spectrometry‐based experiment design for targeted analytes. Bioflavonoids were identified and structurally characterized based on tandem mass spectrometry fragmentation, comparing the retention time of authentic standard and multiple reaction monitoring transition for quantitative assessment. As a result of this study, 10 plant species were identified as a new sources of catechin, epicatechin, quercetin‐3 4'‐di‐O‐glucoside, isoorientin, orientin, vitexin, isovitexin, rutin, luteolin 7‐O‐glucoside, isoquercitrin, isorhamnetin‐3‐O‐rutinoside, quercetin, luteolin, and kaempferol. Moreover, 24 plant species were also recognized as alternative sources of targeted bioflavonoids. Moreover, the semi‐quantitative analysis of analytes revealed huge variations in the quantity of the analyzed flavonoids among the plants of the Fabaceae family. Consequently, the liquid chromatography‐mass spectrometry‐based approach was successfully utilized for the exploration of chemical diversity in the Fabaceae family and to identify new/alternative sources of targeted flavonoids.
Evolutionary Many‐objective Optimization: Difficulties, Approaches, and Discussions
Authors: Sato Hiroyuki , Ishibuchi Hisao 
Published: March 2023

AbstractPopulation‐based evolutionary algorithms are suitable for solving multi‐objective optimization problems involving multiple conflicting objectives. This is because a set of well‐distributed solutions can be obtained by a single run, which approximate the optimal tradeoff among the objectives. Over the past three decades, evolutionary multi‐objective optimization has been intensively studied and used in various real‐world applications. However, evolutionary multi‐objective optimization faces various difficulties as the number of objectives increases. The simultaneous optimization of more than three objectives, which is called many‐objective optimization, has attracted considerable research attention. This paper explains various difficulties in evolutionary many‐objective optimization, reviews representative approaches, and discusses their effects and limitations. © 2023 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
Surgical anatomy of hypoglossal canal for various skull base surgeries
Authors: Kalthur Sneha Guruprasad , Padmashali Supriya , Bhattarai Chachuu , Gupta Chandni 
Published: March 2023

Abstract
Purpose
Anatomical knowledge of the hypoglossal canal is very important in relation to drilling of occipital condyle, jugular tubercle etc. So, this study was conducted to identify various morphometric and morphological features of the hypoglossal canal and its distance from adjacent structures relative to stable and reliable anatomic landmarks.

Methods
The study was performed on 142 hypoglossal canals of 71 adult human dry skulls. The parameters measured were the transverse, vertical diameter, depth of the hypoglossal canal. The distances from the hypoglossal canal to the foramen magnum, occipital condyle and jugular foramen were also noted. In addition, the different locations of the hypoglossal canal orifices in relation to the occipital condyle were assessed. The different shapes and types of the hypoglossal canal were also noted.

Results
There was significant difference (p < 0.05) in measurements taken on the right and left sides in males and females. The intracranial orifice of hypoglossal canal was present in middle 1/3rd in 100% of occipital condyle for both genders. The extracranial orifice of the hypoglossal canal was found to be in the anterior 1/3rd in 99% and 93.7% for male and female, respectively. Simple hypoglossal canal with no traces of partition was found to be more in males and females. The most common shape noted was oval both in males and females (71.8% and 68.7% respectively).

Conclusion
The results of the dimensions of the hypoglossal canal and its distance from other bony landmarks will be helpful for neurosurgeons to plan which surgical approaches should be undertaken while doing various surgeries in posterior cranial fossa.
Planned versus unplanned rotational atherectomy for plaque modification in severely calcified coronary lesions
Authors: Bacmeister Lucas , Breitbart Philipp , Sobolewska Karolina , Kaier Klaus , Rahimi Faridun , Löffelhardt Nikolaus , Valina Christian , Neumann Franz-Josef , Westermann Dirk , Ferenc Miroslaw 
Published: March 2023

Abstract
Background
Evidence on the optimal timing of RA is scarce, although increased periprocedural complications for unplanned procedures have been reported.

Aims
To compare planned versus unplanned use of rotational atherectomy (RA) for plaque modification in patients with severely calcified coronary lesions.

Methods
Procedural and 1-year follow-up data of planned (n = 562 lesions in 448 vessels of 416 patients) and unplanned (n = 490 lesions in 435 vessels of 403 patients) RA between 2008 and 2020 were analyzed using the propensity score methods. The primary composite endpoint was target lesion failure (TLF), defined as cardiovascular death (CVD), target vessel myocardial infarction (TVMI), or target lesion revascularization (TLR).

Results
Angiographic success was > 99% in both groups. Fluoroscopy time and contrast volume were significantly lower in planned RA (p < 0.001). Periprocedural complications including slow-flow, coronary dissection, and MI occurred in 4.8% after planned, and in 5.7% after unplanned RA. TLF occurred in 18.5% after planned, and in 14.7% after unplanned RA. Weighted subdistribution hazard ratios for TLFs revealed an unfavorable 1-year outcome for planned RA (sHR 1.62 [1.07–2.45], p = 0.023), which was driven by TLR (sHR 2.01 [1.18–3.46], p = 0.011), but not by CVD, or TVMI. No differences were observed in all-cause mortality.

Conclusions
Unplanned RA was associated with favorable outcome when compared to planned RA. Thus, RA can safely be reserved for lesions that prove untreatable by conventional means. Randomized and prospective trials are needed to evaluate a predominant use of rotational atherectomy as a bailout strategy in the future.

Graphical abstract
Traditional and new lifestyle interventions to prevent breast cancer recurrence (TANICA): a qualitative study
Authors: Aflague Tanisha F. , Esquivel Monica K. , Hammond Kristi , Delos Reyes Bernice , Kaholokula Joseph Keawe‘aimoku 
Published: March 2023

Abstract
Purpose
Breast cancer is the second cause of death from cancer in Guam and Hawai‘i and disproportionately impacts Native Hawaiian, CHamoru, and Filipino women. Although a few culturally informed interventions addressing breast cancer survivorship exist, none have been developed or tested for Native Hawaiian, CHamoru, and Filipino women. To address this, the TANICA study began with key informant interviews in 2021.

Methods
Purposive sampling and grounded theory approaches were used to conduct semi-structured interviews with individuals experienced in providing healthcare or implementing community programs and/or research with ethnic groups of interest in Guam and Hawai‘i. A literature review and expert consultation identified intervention components, engagement strategies, and settings. Interview questions aimed to understand the relevance of evidence-based interventions and explored socio-cultural factors. Participants completed demographics and cultural affiliation surveys. Interviews were independently analyzed by trained researchers. Themes were mutually agreed upon by reviewers and key themes were identified based on frequencies.

Results
Nineteen interviews were conducted in Hawai‘i (n=9) and Guam (n=10). Interviews confirmed the relevance of most of the previously identified evidence-based intervention components for Native Hawaiian, CHamoru, and Filipino breast cancer survivors. Ideas around culturally responsive intervention components and strategies emerged that were shared across and unique to each ethnic group and site.

Conclusion
Evidence-based intervention components appear relevant, yet cultural and place-based strategies are needed for Native Hawaiian, CHamoru, and Filipino women in Guam and Hawai‘i. Future research should triangulate these findings with the lived experiences of Native Hawaiian, CHamoru, and Filipino breast cancer survivors to develop culturally informed interventions.
Post-diagnostic statin use and breast cancer-specific mortality: a population-based cohort study
Authors: Scott Oliver William , TinTin Sandar , Harborg Sixten , Kuper-Hommel Marion J. J. , Lawrenson Ross , Elwood J. Mark 
Published: March 2023

Abstract
Purpose
Statins are the most widely prescribed cholesterol lowering medications and have been associated with both improved and unchanged breast cancer outcomes in previous studies. This study examines the association between the post-diagnostic use of statins and breast cancer outcomes (death and recurrence) in a large, representative sample of New Zealand (NZ) women with breast cancer.

Methods
Women diagnosed with a first primary breast cancer between 2007 and 2016 were identified from four population-based regional NZ breast cancer registries and linked to national pharmaceutical data, hospital discharges, and death records. Cox proportional hazard models were used to estimate the hazard of breast cancer-specific death (BCD) associated with any post-diagnostic statin use.

Results
Of the 14,976 women included in analyses, 27% used a statin after diagnosis and the median follow up time was 4.51 years. Statin use (vs non-use) was associated with a statistically significant decreased risk of BCD (adjusted hazard ratio: 0.74; 0.63–0.86). The association was attenuated when considering a subgroup of ‘new’ statin users (HR: 0.91; 0.69–1.19), however other analyses revealed that the protective effect of statins was more pronounced in estrogen receptor positive patients (HR: 0.77; 0.63–0.94), postmenopausal women (HR: 0.74; 0.63–0.88), and in women with advanced stage disease (HR: 0.65; 0.49–0.84).

Conclusion
In this study, statin use was associated with a statistically significant decreased risk of breast cancer death, with subgroup analyses revealing a more protective effect in ER+ patients, postmenopausal women, and in women with advanced stage disease. Further research is warranted to determine if these associations are replicated in other clinical settings.
Hope speech detection in Spanish
Authors: García-Baena Daniel , García-Cumbreras Miguel Ángel , Jiménez-Zafra Salud María , García-Díaz José Antonio , Valencia-García Rafael 
Published: March 2023

AbstractIn recent years, systems have been developed to monitor online content and remove abusive, offensive or hateful content. Comments in online social media have been analyzed to find and stop the spread of negativity using methods such as hate speech detection, identification of offensive language or detection of abusive language. We define hope speech as the type of speech that is able to relax a hostile environment and that helps, gives suggestions and inspires for good to a number of people when they are in times of illness, stress, loneliness or depression. Detecting it automatically, in order to give greater diffusion to positive comments, can have a very significant effect when it comes to fighting against sexual or racial discrimination or when we intend to foster less bellicose environments. In this article we perform a complete study on hope speech, analyzing existing solutions and available resources. In addition, we have generated a quality resource, SpanishHopeEDI, a new Spanish Twitter dataset on LGBT community, and we have conducted some experiments that can serve as a baseline for further research.
The macroinvertebrate fauna of maintained and abandoned beaver dams
Authors: Schloemer Sara , Hörren Thomas , Lorenz Armin W. , Hering Daniel 
Published: March 2023

AbstractBeavers and their dams, once common in small streams throughout Eurasia and North America, are returning to their original range. Beaver dams are special habitats in the aquatic-terrestrial interface, but their macroinvertebrate fauna is hardly known. This study aims to qualify and quantify the invertebrate fauna of beaver dams, taking into account the maintenance status of the dams. Nine different areas covering the top, middle and base zones of eight maintained and eight abandoned beaver dams were sampled using a specially designed suction device. The invertebrate community of beaver dams proved to be diverse and predominantly rheophilic. Community composition reflects higher flow velocities in streamside habitats; this gradient is more pronounced in maintained than in abandoned dams. Shredders are the most abundant feeding type, but they are less frequent in streamside habitats, in particular in those of maintained dams, where passive filter feeders prevail. Terrestrial/Semiaquatic taxa colonising hygropetric areas were found in streamside habitats especially of abandoned dams. Our results underline that beaver dams provide a wide variety of environmental conditions and habitat types, which enhance biodiversity in small streams and their floodplains. Beaver dams in riverine landscapes should therefore be much more valued in floodplain conservation and management.
Concern for cuckoo bumblebees (Bombus subgenus Psithyrus): addressing our lack of knowledge
Authors: Bower Reanne , Bulling Mark , Norton Briony 
Published: March 2023

AbstractBumblebees (genus Bombus) have received increased academic and conservation attention with the recognition of a global pollinator crisis. However, the Bombus subgenus Psithyrus (cuckoo bumblebees), has been overlooked. Psithyrus species parasitise social Bombus species and are frequently viewed as being detrimental to their hosts. This lack of attention, combined with the taxon’s relatively low abundances and enhanced vulnerability to climate change due to its phenological dependence on Bombus, means there is an urgent conservation challenge facing Psithyrus. We found that academic literature focused on Psithyrus comprised less than 2% of the total works on Bombus, despite forming approximately 11% of Bombus species. We argue that species of the Psithyrus subgenus have key roles in the ecosystem and have been potentially overlooked bioindicator of Bombus diversity. We present evidence suggesting that the close phenological ties between Psithyrus and its hosts are being impacted by climate change. Going forward, research on Psithyrus distributions and phenology will be essential for conserving this subgenus. Additionally, addressing these areas provides broader opportunities to improve our understanding of ecosystem dynamics under climate change and their associated links with ecosystem services.
Effectiveness of a Brief Engagement, Problem-Solving, and Triage Strategy for High School Students: Results of a Randomized Study
Authors: Bruns Eric J. , Lee Kristine , Davis Chayna , Pullmann Michael D. , Ludwig Kristy , Sander Mark , Holm-Hansen Cheryl , Hoover Sharon , McCauley Elizabeth M. 
Published: March 2023

AbstractSchools offer an advantageous setting for the prevention, early identification, and treatment of mental health problems for youth. However, school mental health (SMH) services are typically not based on evidence for effectiveness, nor are they efficiently delivered, with SMH practitioners (SMHPs) able to only treat a small number of students in need. The current study evaluated the feasibility, acceptability, efficiency, and outcomes of a four-session assessment, engagement, problem-solving, and triage strategy for SMHPs that aimed to improve efficiency while being based on elements of evidence-based care. The study, conducted in 15 US school districts in three states, used stratified random assignment to assign 49 high schools and their participating SMHP(s) to either the Brief Intervention for School Clinicians (BRISC; N = 259 students) or services as usual (SAU; N = 198 students). SMHPs implemented BRISC elements with adequate to excellent fidelity and reported the strategy was feasible and well-aligned with presenting problems. Students assigned to BRISC reported significantly greater engagement in SMH at 2 months and completion of SMH treatment by 6 months. BRISC-assigned SMHPs reported significantly greater treatment completion after four sessions (53.4%) compared to SAU (15.4%). Students in the BRISC condition also reported significantly greater reduction in problem severity as evaluated by the Youth Top Problems Assessment. No differences were found for anxiety or depression symptoms or overall functioning. Results indicate that BRISC is a feasible early intervention and triage strategy that may aid in more efficient provision of SMH services with no compromise to SMH effectiveness.
Upscaling agroforestry in the tropics through actor-networks: a comparative case study of cacao farming systems in two regions of Colombia
Authors: Rodríguez Tatiana , Bonatti Michelle , Löhr Katharina , Bravo Aura , Del Río Martha , Lana Marcos , Sieber Stefan 
Published: March 2023

AbstractAgroforestry systems (AFS) upscaling has the potential to integrate sustainability and resilience objectives into agriculture. However, this is a daunting task requiring multi-actor collaboration across public and private sectors at multiple governance levels, coupled with innovative approaches to jointly managing AFS knowledge. Understanding such multi-actor interactions from a network perspective may help to unravel how social structures, created by relational patterns enhance or hinder AFS upscaling. Our paper aims to comparatively explore the role of regional actor-networks on AFS upscaling for a selected farming system. By conducting semi-structured interviews, we collected information about the ties of 86 actors supporting cacao agroforestry systems (CAFS) across two regions of Colombia. We use social network analysis (SNA) to comparatively visualize and understand the general structure of these networks, find relational patterns between the diverse categories of actors involved, and identify a set of key players bridging the majority of the actors within these networks. We find highly centralized networks that connect multiple actors by a low number of mostly non-reciprocal ties. Within these networks, we identify a predominance of bridging ties over bonding ties, homophily patterns among research and education institutions, and heterophily configurations among farmer-based organizations. We also find that the composition of the sets of key actors and the platforms where they converge varies substantially from region to region due to decentralized agricultural policies and differing characteristics across regions. Our approach provides key entry points for promoting multi-actor coalitions that can effectively expand the benefits of AFS in tropical agricultural systems.
Suicide risk among adolescents and young adults after cancer diagnosis: analysis of 34 cancer groups from 2009 to 2019
Authors: Michalek Irmina Maria , Caetano dos Santos Florentino Luciano , Wojciechowska Urszula , Didkowska Joanna 
Published: March 2023

Abstract
Purpose
We aimed to identify granular groups with an increased risk of suicide among adolescents and young adult (AYA) patients with a previous malignant neoplasm diagnosis.

Methods
We deployed a cohort of all cases of primary malignant neoplasms diagnosed between the 1st of January 2009 and the 31st of December 2019 among individuals aged 15–39 years registered in the Polish National Cancer Registry. To assess the risk of suicide in comparison with the general AYA population, we calculated sex–age–year standardized mortality ratios (SMR) with 95% confidence intervals (CI).

Results
A total of 50,298 cancer patients (22,111 men and 28,187 women) were included in this study. The risk of suicide for AYA after cancer diagnosis was 2.39-fold higher than that for AYA in the general population (SMR 2.39, 95% CI 1.69 to 3.28). The risk in women (SMR 4.18, 95% CI 1.68 to 8.62) was higher than that in men (SMR 2.18, 95% CI 1.48 to 3.09). A significantly higher risk of suicide was observed in men with testicular cancer (SMR 2.46, 95% CI 1.37 to 4.05).

Conclusions
Polish AYA diagnosed with cancer had an almost 2.5-fold higher risk of suicide than the general AYA population. The particular risk group was men with testicular cancer within 2–3 and 5–10 years after cancer diagnosis.

Implications for Cancer Survivors
To better identify patients at risk of suicide, there is a need to create or adapt screening tools, educate cancer care providers and family physicians, and integrate psychological services into select cancer care specialties.