bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uluslararası Öğrenciler İçin Hazırlanmış Ders Kitaplarının 21. Yüzyıl Becerileri Açısından İncelenmesi: İstanbul Kitap Seti
Authors: GUVEN Zeliha Zuhal , BÜLBÜL Ayten 
Published: May 2023

Bilim ve teknoloji alanında yaşanan hızlı ilerlemelerin yanı sıra sosyal, siyasal ve ekonomik nedenlerden dolayı toplum hayatında ortaya
çıkan değişimler bireylerin farklı açılardan yetkin olmasını sağlayacak beceriler kazanmalarını gerektirmektedir. 21. yüzyıl becerileri olarak
adlandırılan bu yetkinlik alanları eleştirel düşünme, yaratıcılık, iletişim kurma, dayanışma ve bilişim teknolojilerini kullanabilme gibi
çeşitli davranışları içerir. Türkiye’de sayısı giderek artan uluslararası öğrencilerin Türkçe öğrenirken 21. yüzyıl becerilerini kazanmaları
ve geliştirmelerine katkıda bulunacak çeşitli imkân ve ortamlar yaratmak mümkündür. Öğrenme ve öğretme sürecinin en önemli
bileşenlerinden biri olan ders kitapları gerek anadil gerekse yabancı dil öğretiminde önemli işlevlere sahiptir. Bu nedenle, ders kitapları
öğrencileri hayata hazırlayacak şekilde hazırlanmalıdır. Bu araştırmada yabancı dil olarak Türkçe öğretiminde kullanılan İstanbul Yabancılar
İçin Türkçe setinde yer alan metinler ve dilsel etkinlikler 21. yüzyıl becerilerine yönelik olma özelliği açısından incelenmiştir. Çalışmada
21. yüzyıl yeterlilik alanları 21. yüzyıl temaları ve 21. yüzyıl becerileri olarak iki ana sınıflandırma altında ele alınmış ve söz konusu kitap
setinde yer alan metinler ile temel dil becerilerine yönelik dilsel etkinlikler bu çerçevede incelenmiştir. Araştırmada nitel araştırma
yöntemlerinden doküman incelemesi yöntemi kullanılarak tüm dil düzeylerindeki metinler ve etkinlikler 21. yüzyıl beceri türlerinin varlığı,
sıklığı ve dağılımı açısından betimlenmiştir. Elde edilen bulguların incelenmesi sonucunda 21. yüzyıl temalarının yer alması bakımından
metinlerde dengeli bir dağılım olmadığı; 21. yüzyıl becerilerinin dilsel becerilere göre yönelik etkinliklerde yer alması bakımından ise
alımlama becerileri ile üretme becerilerine eşit ölçüde yer verilmediği görülmüştür.
Diagnostic Use of Serum Ferritin as a Predictor of Hospital Outcome at Admission in Patients with Infective Endocarditis
Authors: Ali Hassan Mahmoud Radwan , ELSaidy Mona Adel , Salama Mai A. ELmonem , Alkassas Amr Fayez 
Published: May 2023

Background: Infective endocarditis (IE) is characterised by a concentration of infection inside the heart; it is caused by a bacterial or fungal infection of the endocardial surface of the heart; and it is linked with substantial morbidity and death.The aim of this research was to assess serum ferritin as an admission predictor of in-hospital prognosis in subjects with IE.
Methods: This case control researchincluded60subjects diagnosed with IEon the basis of the modified duke's criteria.Subjects were allocated equally into two groups: group I: IE subjects who were further subdivided into two groups based on presence or absence of major adverse cardiovascular events (subgroup A: 19 patients who showed IE complications or major adverse cardiac events during hospitalization and subgroup B: 11 patients who showed a smooth course during hospitalization without major adverse cardiac events or IE complications) and IE subjects as well as age and sex matched 30 healthy subjects.
Results: serum ferritin level were significantly increased in group I than group II (P value<0.05). Serum ferritin level was significantly increased in subgroup A than subgroup B (P value<0.001). serum ferritin can significantly predict bad outcome (P value<0.001) with AUC of 0.964 (95% CI: 0.881 – 0.995). At cut off >1200, serum ferritin can significantly predict bad outcome with 94.44% sensitivity, 92.86% specificity, 85% PPV and 97.5% NPV.
Conclusions: Serum ferritin was significantly increased in IE subjects who experiencedproblems on admission as compared to IE subjects who didn’t.
Comparison of Marketing Efficiency in the Sheep-fattening Business Supply Chain Scheme in Langkat District
Authors: Marisa Julia , Wibowo Fachrina , Kurniawan Ridho 
Published: May 2023

Aims: Analyze the economic efficiency of production and describe the supply chain scheme for the fattening sheep business in Sei Bingai District, Langkat Regency.
Study Design: This type of research is quantitative descriptive research.
Place and Duration of Study: The research was conducted from November 2022-January 2023 in Sei Bingai District, Langkat Regency.
Methodology: Data collection techniques include several techniques, namely using questionnaires through Focus Group Discussions (FGD), in-depth interviews with respondents, document analysis, informal discussions, and direct observation. The data analysis method used is Economic Efficiency Analysis and System Supply Chain.
Results: The results showed that 1) The marketing of fattening sheep in Sei Bingai District, Langkat Regency, has been efficient. This is proven by the results of efficiency calculations which show the efficiency of the three supply chain schemes is below 50%. Compared to the other two channels, scheme two is said to be the most efficient because the efficiency value is only 13.2%. In comparison, the highest efficiency value is in scheme three, followed by the first channel scheme. 2) The supply chain scheme for fattening sheep in Sei Bingai District, Langkat Regency, consists of producer breeders, agents, regional market intermediaries, and consumers.
Conclusion: Improvements in performance indicators provide good performance results for the sheep-fattening supply chain. Efforts to improve the indicators of order fulfillment and compliance with standards are carried out by having good cooperation with suppliers. Companies must be more involved in handling the quality and quantity of fattening sheep.
Multicenter External Validation of the Deep Pelvic Endometriosis Index Magnetic Resonance Imaging Score
Authors: Thomassin-Naggara Isabelle , Monroc Michele , Chauveau Benoit , Fauconnier Arnaud , Verpillat Pauline , Dabi Yohann , Gavrel Marie , Bolze Pierre-Adrien , Darai Emile , Touboul Cyril , Lamrabet Samia , Collinet Pierre , Zareski Elise , Bourdel Nicolas , Roman Horace , Rousset Pascal 
Published: May 2023

ImportancePreoperative mapping of deep pelvic endometriosis (DPE) is crucial as surgery can be complex and the quality of preoperative information is key.ObjectiveTo evaluate the Deep Pelvic Endometriosis Index (dPEI) magnetic resonance imaging (MRI) score in a multicenter cohort.Design, Setting, and ParticipantsIn this cohort study, the surgical databases of 7 French referral centers were retrospectively queried for women who underwent surgery and preoperative MRI for DPE between January 1, 2019, and December 31, 2020. Data were analyzed in October 2022.InterventionMagnetic resonance imaging scans were reviewed using a dedicated lexicon and classified according to the dPEI score.Main outcomes and measuresOperating time, hospital stay, Clavien-Dindo–graded postoperative complications, and presence of de novo voiding dysfunction.ResultsThe final cohort consisted of 605 women (mean age, 33.3; 95% CI, 32.7-33.8 years). A mild dPEI score was reported in 61.2% (370) of the women, moderate in 25.8% (156), and severe in 13.1% (79). Central endometriosis was described in 93.2% (564) of the women and lateral endometriosis in 31.2% (189). Lateral endometriosis was more frequent in severe (98.7%) vs moderate (48.7%) disease and in moderate vs mild (6.7%) disease according to the dPEI (P &amp;lt; .001). Median operating time (211 minutes) and hospital stay (6 days) were longer in severe DPE than in moderate DPE (operating time, 150 minutes; hospital stay 4 days; P &amp;lt; .001), and in moderate than in mild DPE (operating time; 110 minutes; hospital stay, 3 days; P &amp;lt; .001). Patients with severe disease were 3.6 times more likely to experience severe complications than patients with mild or moderate disease (odds ratio [OR], 3.6; 95% CI, 1.4-8.9; P = .004). They were also more likely to experience postoperative voiding dysfunction (OR, 3.5; 95% CI, 1.6-7.6; P = .001). Interobserver agreement between senior and junior readers was good (κ = 0.76; 95% CI, 0.65-0.86).Conclusions and RelevanceThe findings of this study suggest the ability of the dPEI to predict operating time, hospital stay, postoperative complications, and de novo postoperative voiding dysfunction in a multicenter cohort. The dPEI may help clinicians to better anticipate the extent of DPE and improve clinical management and patient counseling.
Endovascular Therapy for Stroke Presenting Beyond 24 Hours
Authors: Kobeissi Hassan , Ghozy Sherief , Adusumilli Gautam , Kadirvel Ramanathan , Brinjikji Waleed , Rabinstein Alejandro A. , Kallmes David F. 
Published: May 2023

ImportancePrevious randomized clinical trials (RCTs) have supported the use of endovascular therapy (EVT) in late-window acute ischemic stroke (AIS; 6-24 hours). However, little is known about the use of EVT in very late-window AIS (&amp;gt;24 hours).ObjectiveTo examine outcomes following EVT for very late-window AIS.Data SourcesA systematic review of the English language literature was conducted using Web of Science, Embase, Scopus, and PubMed to search for articles published from database inception until December 13, 2022.Study SelectionThis systematic review and meta-analysis included published studies regarding very late-window AIS treated with EVT. Multiple reviewers screened studies, and an extensive manual search of the references of included articles was performed to identify any missed articles. Of the 1754 initially retrieved studies, 7 published between 2018 and 2023 were ultimately included.Data Extraction and SynthesisData were extracted independently by multiple authors and evaluated for consensus. Data were pooled using a random-effects model. This study is reported per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guideline, and the protocol was prospectively registered with PROSPERO.Main Outcomes and MeasuresThe primary outcome of interest was functional independence, as assessed with 90-day modified Rankin Scale (mRS) scores (0-2). Secondary outcomes included thrombolysis in cerebral infarction (TICI) scores (2b-3 or 3), symptomatic intracranial hemorrhage (sICH), 90-day mortality, early neurological improvement (ENI), and early neurological deterioration (END). Frequencies and means were pooled with the corresponding 95% CIs.ResultsThis review included 7 studies involving a total of 569 patients. The mean baseline National Institutes of Health Stroke Scale score was 13.6 (95% CI, 11.9-15.5), and the mean Alberta Stroke Program Early CT Score was 7.9 (95% CI, 7.2-8.7). The mean time from last known well and/or onset to puncture was 46.2 hours (95% CI, 32.4-65.9 hours). Frequencies for the primary and secondary outcomes were 32.0% (95% CI, 24.7%-40.2%) for functional independence (90-day mRS scores of 0-2) and 81.9% (95% CI, 78.5%-84.9%) for TICI scores of 2b to 3, 45.3% (95% CI, 36.6%-54.4%) for TICI scores of 3, 6.8% (95% CI, 4.3%-10.7%) for sICH, and 27.2% (95% CI, 22.9%-31.9%) for 90-day mortality. In addition, frequencies were 36.9% (95% CI, 26.4%-48.9%) for ENI and 14.3% (95% CI, 7.1%-26.7%) for END.Conclusions and RelevanceIn this review, EVT for very late-window AIS was associated with favorable frequencies of 90-day mRS scores of 0 to 2 and TICI scores of 2b to 3 and with low frequencies of 90-day mortality and sICH. These results suggest that EVT may be safe and associated with improved outcomes for very late-window AIS, although RCTs and prospective, comparative studies are needed to determine which patients may benefit from very late intervention.
Association of Staphylococcus aureus Colonization With Severity of Acute Radiation Dermatitis in Patients With Breast or Head and Neck Cancer
Authors: Kost Yana , Rzepecki Alexandra K. , Deutsch Alana , Birnbaum Mathew R. , Ohri Nitin , Hosgood H. Dean , Lin Juan , Daily Johanna P. , Shinoda Kosaku , McLellan Beth N. 
Published: May 2023

ImportancePathogenesis of acute radiation dermatitis (ARD) is not completely understood. Pro-inflammatory cutaneous bacteria may contribute to cutaneous inflammation after radiation therapy.ObjectiveTo evaluate whether nasal colonization with Staphylococcus aureus (SA) before radiation therapy is associated with ARD severity in patients with breast or head and neck cancer.Design, Setting, and ParticipantsThis prospective cohort study with observers blinded to colonization status was conducted from July 2017 to May 2018 at an urban academic cancer center. Patients aged 18 years or older with breast or head and neck cancer and plans for fractionated radiation therapy (≥15 fractions) with curative intent were enrolled via convenience sampling. Data were analyzed from September to October 2018.ExposuresStaphylococcus aureus colonization status before radiation therapy (baseline).Main Outcomes and MeasuresThe primary outcome was ARD grade using the Common Terminology Criteria for Adverse Event Reporting, version 4.03.ResultsAmong 76 patients analyzed, mean (SD) age was 58.5 (12.6) years and 56 (73.7%) were female. All 76 patients developed ARD: 47 (61.8%) with grade 1, 22 (28.9%) with grade 2, and 7 (9.2%) with grade 3. The prevalence of baseline nasal SA colonization was higher among patients who developed grade 2 or higher ARD compared with those who developed grade 1 ARD (10 of 29 [34.5%] vs 6 of 47 [12.8%]; P = .02, by χ2 test).Conclusions and RelevanceIn this cohort study, baseline nasal SA colonization was associated with development of grade 2 or higher ARD in patients with breast or head and neck cancer. The findings suggest that SA colonization may play a role in the pathogenesis of ARD.
A comparative study of deep learning‐based knowledge‐based planning methods for 3D dose distribution prediction of head and neck
Authors: Osman Alexander F. I. , Tamam Nissren M. , Yousif Yousif A. M. 
Published: May 2023

AbstractPurposeIn this paper, we compare four novel knowledge‐based planning (KBP) algorithms using deep learning to predict three‐dimensional (3D) dose distributions of head and neck plans using the same patients’ dataset and quantitative assessment metrics.MethodsA dataset of 340 oropharyngeal cancer patients treated with intensity‐modulated radiation therapy was used in this study, which represents the AAPM OpenKBP – 2020 Grand Challenge dataset. Four 3D convolutional neural network architectures were built. The models were trained on 64% of the data set and validated on 16% for voxel‐wise dose predictions: U‐Net, attention U‐Net, residual U‐Net (Res U‐Net), and attention Res U‐Net. The trained models were then evaluated for their performance on a test data set (20% of the data) by comparing the predicted dose distributions against the ground‐truth using dose statistics and dose‐volume indices.ResultsThe four KBP dose prediction models exhibited promising performance with an averaged mean absolute dose error within the body contour <3 Gy on 68 plans in the test set. The average difference in predicting the D99 index for all targets was 0.92 Gy (p = 0.51) for attention Res U‐Net, 0.94 Gy (p = 0.40) for Res U‐Net, 2.94 Gy (p = 0.09) for attention U‐Net, and 3.51 Gy (p = 0.08) for U‐Net. For the OARs, the values for the and indices were 2.72 Gy (p < 0.01) for attention Res U‐Net, 2.94 Gy (p < 0.01) for Res U‐Net, 1.10 Gy (p < 0.01) for attention U‐Net, 0.84 Gy (p < 0.29) for U‐Net.ConclusionAll models demonstrated almost comparable performance for voxel‐wise dose prediction. KBP models that employ 3D U‐Net architecture as a base could be deployed for clinical use to improve cancer patient treatment by creating plans with consistent quality and making the radiotherapy workflow more efficient.
V Doping in NASICON‐Structured Na3MnTi(PO4)3 Enables High‐Energy and Stable Sodium Storage
Authors: Hu Ping , Cai Congcong , Li Xinyuan , Wei Zihe , Wang Mengyao , Chen Changliang , Zhu Ting , Mai Liqiang , Zhou Liang 
Published: May 2023

AbstractNASICON‐structured Na3MnTi(PO4)3 represents an appealing cathode for sodium storage. However, the low potential from Ti3+/4+ redox pair (≈2.1 V versus Na+/Na), undesirable rate capability, and unfavorable cyclability have inhibited its practical application. Herein, this study designs a Na3.1MnTi0.9V0.1(PO4)3 (NMTVP) cathode material by doping V into the Na3MnTi(PO4)3. The V substitution not only increases the medium discharge voltage, but also increases the capacity. The as‐prepared NMTVP demonstrates a four‐step redox reaction from the redox couples of V5+/4+ (≈4.1 V), Mn4+/3+ (≈4.0 V), Mn3+/2+ (≈3.6 V), and V4+/3+ (3.4 V). The NMTVP delivers a high capacity (118.5 mAh g−1 at 0.1 C), a high medium discharge voltage (3.53 V), a decent energy density (422 Wh kg−1), and an ideal cyclability (86% retention after 4500 cycles at 5 C). In situ X‐ray diffraction (XRD) uncovers the reversible structural evolution between Na3.1MnTi0.9V0.1(PO4)3 and Na0.9MnTi0.9V0.1(PO4)3 phases. The assembled NMTVP//hard carbon (HC) full cell also delivers a high capacity, a high operating voltage, and a good cyclability. This contribution offers new insights into the design of high‐energy NASICON‐structured cathode materials.
3D‐Printed Hollow Microneedle‐Lateral Flow Devices for Rapid Blood‐Free Detection of C‐Reactive Protein and Procalcitonin
Authors: Turner Joseph G. , Lay Emily , Jungwirth Ute , Varenko Valentyna , Gill Harinderjit S. , Estrela Pedro , Leese Hannah S. 
Published: May 2023

AbstractHollow microneedle devices as a technology for interstitial fluid extraction show promise for the minimally invasive point‐of‐care detection of analytes. Despite increasing efforts toward on‐patch diagnostics, the use of hollow microneedles has been limited due to the complexity caused by integrating hollow microneedles with established point‐of‐care diagnostic techniques. Herein, a 3D printing method is utilized, to provide low‐cost manufacturing of custom‐designed hollow microneedle devices, allowing for easy integration with lateral flow assays for rapid and blood‐free diagnostics. Microneedle surface modification through PEGylation results in prolonged and enhanced hydrophilicity, enabling passive uptake of small volume samples (≈22.5 µL) and an enhanced shelf life. The hollow microneedle devices are deemed non‐cytotoxic to cell types found within the skin following short‐term and prolonged exposure in accordance with ISO10993. Furthermore, the devices demonstrate high mechanical strength and successfully penetrate porcine skin grafts without damaging the surrounding skin morphology. This work also demonstrates for the first time the use of hollow microneedles for the simultaneous detection, at clinically relevant concentrations, of C‐reactive protein (LoD = 10 µg mL−1) and procalcitonin (LoD = 1 ng mL−1), through porcine skin, ultimately demonstrating the beneficial use of manufactured 3D‐printed hollow microneedles towards low‐cost blood‐free diagnostics of inflammation markers.
Phase‐Purified Ruddlesden–Popper Perovskites Vertically Oriented in Block Copolymer Nanostructures for Environmentally Stable Light Conversion and Charge Trapping
Authors: Kim Sohee , Lee Hyeokjung , Han Hyowon , Park Youjin , Lee Kyuho , Kim Yeeun , Zan Guangtao , Lee Jiyeon , Kim Dongjun , Kim Jiwon , Jeong Beomjin , Kim Ji‐Hee , Park Cheolmin 
Published: May 2023

Abstract2D Ruddlesden–Popper perovskites (RPPs) with 2D layer‐tunable optoelectronic properties suffer from randomly oriented multiple phases. Herein, an efficient method for developing RPP films with controlled phase purity and crystal orientation via a one‐step synthesis of RPPs in a self‐assembled block copolymer (BCP) film is demonstrated. RPP crystals with a target phase <n = 2 or 3> are preferentially embedded in the poly(ethylene oxide) domains of a polystyrene‐block‐poly(ethylene oxide) nanostructured film. Interestingly, rapid self‐assembly with the BCP results in phase‐purified n = 2 and 3 targeted RPPs with a target phase percentage two and four times higher, respectively, than that of pristine RPP. Furthermore, RPP crystals synthesized within BCP are preferentially oriented with their b‐axis parallel to the surface normal. The photoluminescence of the composite film is significantly enhanced, allowing environmentally stable ultraviolet‐to‐blue color conversion. Moreover, semiconducting RPP crystals nanopatterned in the BCP are successfully used as charge‐trapping floating nanogates, resulting in a non‐volatile field‐effect transistor memory.
A Base‐Free, Low Temperature Click and Release Reaction for the In Situ Generation of Diazomethane
Authors: Schembri Luke S. , Olaniran Esther , Söderström Marcus , Skillinghaug Bobo , Odell Luke R. 
Published: May 2023

AbstractDiazomethane is a powerful reagent for numerous chemical reactions such as esterifications and the homologation of carboxylic acids. Unfortunately, the synthetic utility of diazomethane is severely limited by its toxicity and highly explosive nature. Diazald® is typically used for ex situ synthesis, however it requires cumbersome and hazardous transfer of diazomethane from a caustic aqueous phase to the reaction medium. Herein, we present a low temperature and base‐free in situ synthesis of diazomethane via a “click and release” reaction between an enamine and sulfonyl azide. Its utility is exemplified by the synthesis of diverse methyl esters in yields of up to 93%. Moreover, diazoketone synthesis from in situ generated diazomethane and acid chlorides was demonstrated for the first time. Finally, trideuteromethylation was achieved using acetone‐d6 as the deuterium source. We anticipate that this method will enable the safer use of diazomethane in organic synthesis and drug discovery programs.
Mesoporous Amorphous Bulk Material Electrodes for Ultrahigh Volumetric Capacity Electrochemical Capacitors
Authors: Li Lun , Guo Changjin , Wang Shuangbao , Hu Wanbiao 
Published: May 2023

AbstractRetaining satisfactory electrochemical performances under high‐mass electrode‐active‐matter loadings is important for energy storage. However, the performance decreases with increasing mass loadings due to a reduction in the ion/electron transport. In this study, a novel mesoporous amorphous bulk (MAB) material strategy is proposed. Co‐based hydroxide KCo1.3(OH)3.6 is directly electro‐deposited on the Ni foam for cathode. Comprehensive structural characterizations confirm the mesoporous, amorphous, and bulk features for KCo1.3(OH)3.6. The fabricated whole MAB‐KCo1.3(OH)3.6@Ni electrode exhibits an ultrahigh full volumetric capacity (123.7 mAh cm−3) with high KCo1.3(OH)3.6 mass loading (11.7 mg cm−2) and excellent cycling stability. Along with the MAB‐KCo1.3(OH)3.6, the mesoporous amorphous features enable fast ion diffusion and provide sufficient electroactive sites for redox reactions. In addition, the bulk nature not only facilitates the electron mobility but also guarantees structural and chemical stability. Therefore, the proposed MAB strategy and explored KCo1.3(OH)3.6 material demonstrate considerable prospects for designing electrode materials and practical applications.