bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraductal tubulopapillary neoplasm
Authors: Yu Catherine , Lokan Julie , Jackett Louise , Nikfarjam Mehrdad , Mills Christopher 
Published: December 2022

A man aged above 70 years old with a medical history of ulcerative colitis presented with unintentional weight loss. A pancreatic mass associated with pancreatic duct dilatation was detected on imaging procedures. Initial investigations including fine needle aspiration and cytology examination were inconclusive. A diagnosis of intraductal tubulopapillary neoplasm (ITPN) was made with histopathology and immunohistochemistry examination on a surgically resected specimen. Two years after surgery, the patient remained well with no radiological evidence of recurrence.ITPN is a rare pancreatic duct tumour with limited case reports in medical literature. Risk factors are not well established. We report the first case of ITPN occurring in a patient with ulcerative colitis. A typical presentation of this rare tumour is reported to encourage clinicians to consider ITPN in the differential diagnoses of a pancreatic mass.
Effect of a home-based inspiratory muscle training programme on functional capacity in postdischarged patients with long COVID: the InsCOVID trial
Authors: Palau Patricia , Domínguez Eloy , Gonzalez Cruz , Bondía Elvira , Albiach Cristina , Sastre Clara , Martínez Maria Luz , Núñez Julio , López Laura 
Published: December 2022

BackgroundFatigue and exercise intolerance are the most common symptoms in patients with long COVID.AimsThis study aimed to evaluate whether a home-based inspiratory muscle training (IMT) programme improves maximal functional capacity in patients’ long COVID after a previous admission due to SARS-CoV-2 pneumonia.MethodsThis study was a single-centre, blinded assessor, randomised controlled trial. Twenty-six patients with long COVID and a previous admission due to SARS-CoV-2 pneumonia were randomly assigned to receive either a 12-week IMT or usual care alone (NCT05279430). The physiotherapist and participants were not blinded. Patients allocated to the IMT arm were instructed to train at home twice daily using a threshold inspiratory muscle trainer and to maintain diaphragmatic breathing during the training session. The usual care arm received no intervention.The primary endpoint was the change in peak oxygen consumption (peakVO2). Secondary endpoints were changes in quality of life (QoL), ventilatory efficiency and chronotropic response during exercise (evaluated by chronotropic index-CIx- formula). We used linear mixed regression analysis for evaluating changes in primary and secondary endpoints.ResultsThe mean age of the sample and time to first visit after discharge were 50.4±12.2 years and 362±105 days, respectively. A total of 11 (42.3%) were female. At baseline, the mean of peakVO2, ventilatory efficiency and CIx were 18.9±5 mL/kg/min, 29.4±5.2 and 0.64±0.19, respectively. The IMT arm improved their peakVO2significantly compared with usual care (+Δ 4.46 mL/kg/min, 95% CI 3.10 to 5.81; p<0.001). Similar positive findings were found when evaluating changes for CIxand some QoL dimensions. We did not find significant changes in ventilatory efficiency.ConclusionIn long COVID patients with a previous admission due to SARS-CoV-2 pneumonia, IMT was associated with marked improvement in exercise capacity and QoL.Trial registration numberNCT05279430.
Coronary calcium score in the initial evaluation of suspected coronary artery disease
Authors: Pedersen Eva Ringdal , Hovland Siren , Karaji Iman , Berge Christ , Mohamed Ali Abukar , Lekven Ole Christian , Kuiper Kier Jan , Rotevatn Svein , Larsen Terje Hjalmar 
Published: December 2022

ObjectiveWe evaluated coronary artery calcium (CAC) scoring as an initial diagnostic tool in outpatients and in patients presenting at the emergency department due to suspected coronary artery disease (CAD).Methods10 857 patients underwent CAC scoring and coronary CT angiography (CCTA) at Haukeland University Hospital in Norway during 2013–2020. Based on CCTA, obstructive CAD was defined as at least one coronary stenosis ≥50%. High-risk CAD included obstructive stenoses of the left main stem, the proximal left ascending artery or affecting all three major vascular territories with at least one proximal segment involved.ResultsMedian age was 58 years and 49.5% were women. The overall prevalence of CAC=0 was 45.0%. Among those with CAC=0, 1.8% had obstructive CAD and 0.6% had high-risk CAD on CCTA. Overall, the sensitivity, specificity, positive predictive value and negative predictive value (NPV) of CAC=0 for obstructive CAD were 95.3%, 53.4%, 30.0% and 98.2%, respectively. However, among patients <45 years of age, although the NPV was high at 98.9%, the sensitivity of CAC=0 for obstructive CAD was only 82.3%.ConclusionsIn symptomatic patients, CAC=0 correctly ruled out obstructive CAD and high-risk CAD in 98.2% and 99.4% of cases. This large registry-based cross-sectional study supports the incorporation of CAC testing in the early triage of patients with chest pain and as a gatekeeper to further cardiac testing. However, a full CCTA may be needed for safely ruling out obstructive CAD in the youngest patients (<45 years of age).
Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma
Authors: Rini Brian I , Signoretti Sabina , Choueiri Toni K , McDermott David F , Motzer Robert J , George Saby , Powles Thomas , Donskov Frede , Tykodi Scott S , Pal Sumanta K , Gupta Saurabh , Lee Chung-Wei , Jiang Ruiyun , Tannir Nizar M 
Published: December 2022

BackgroundPatients with advanced renal cell carcinoma with sarcomatoid features (sRCC) have a poor prognosis and limited therapeutic options. First-line nivolumab plus ipilimumab (NIVO+IPI) provided efficacy benefits over sunitinib (SUN) in patients with intermediate/poor-risk sRCC at 42 months minimum follow-up in the phase 3 CheckMate 214 trial. In this exploratory post hoc analysis, we report clinical efficacy of NIVO+IPI in sRCC after a minimum follow-up of 5 years.MethodsIn CheckMate 214, patients with clear cell advanced RCC were randomized to NIVO 3 mg/kg plus IPI 1 mg/kg every 3 weeks (four doses), then NIVO 3 mg/kg every 2 weeks versus SUN 50 mg once daily (4 weeks; 6-week cycles). Randomized patients with sRCC were identified via independent central pathology review of archival tumor tissue or histological classification per local pathology report. Overall survival (OS), as well as progression-free survival (PFS) and objective response rate (ORR) per independent radiology review using Response Evaluation Criteria in Solid Tumors V.1.1, were evaluated in all International Metastatic Renal Cell Carcinoma Database Consortium intermediate/poor-risk sRCC patients and by baseline tumor PD-L1 expression level (≥1% vs <1%). Safety outcomes are reported using descriptive statistics.ResultsIn total, 139 patients with intermediate/poor-risk sRCC were identified (NIVO+IPI, n=74; SUN, n=65). At 5 years minimum follow-up, more patients remained on treatment with NIVO+IPI versus SUN (12% vs zero). Efficacy benefits with NIVO+IPI versus SUN were maintained with median OS of 48.6 vs 14.2 months (HR 0.46), median PFS of 26.5 vs 5.5 months (HR 0.50), and ORR 60.8% vs 23.1%. In addition, median duration of response was longer (not reached vs 25.1 months), and more patients had complete responses (23.0% vs 6.2%) with NIVO+IPI versus SUN, respectively. Efficacy was better with NIVO+IPI versus SUN regardless of tumor PD-L1 expression, but the magnitude of OS, PFS, and ORR benefits with NIVO+IPI was greater for sRCC patients with tumor PD-L1 ≥1%. No new safety signals emerged in either arm with longer follow-up.ConclusionsAmong patients with intermediate/poor-risk sRCC, NIVO+IPI maintained long-term survival benefits and demonstrated durable and deep responses over SUN at minimum follow-up of 5 years, supporting NIVO+IPI as a preferred first-line therapy in this population.Trial registration numberNCT02231749.
Sex, relationships and ‘everyday psychology’ on British magazine problem pages, c. 1960–1990
Authors: Loughran Tracey 
Published: December 2022

The later decades of the 20th century saw dramatic changes in sexual attitudes and behaviour in Britain: rates of divorce and remarriage increased; premarital sex and illegitimacy became more common, even as the pill and legal abortion opened up new reproductive choices; and following on from the decriminalisation of homosex, liberation movements began to celebrate gay lives. These shifts generated new possibilities, but often entailed much inner turmoil. The same period witnessed an unprecedented flourishing of professional and popular psychological expertise. Influential social and cultural theorists have argued that the intertwined rise of “permissiveness” and therapeutic culture caused an important shift in the ethical dimensions of modern life, in which citizens and subjects came to idolise self-realisation over the public good.This article uses women’s magazine problem pages, exploring the role of advice columnists on and off the page, to examine the intersections of “permissiveness” and the psychologisation of everyday life. Millions looked to agony aunts in mass-market women’s magazines to help them negotiate new emotional and sexual worlds. As purveyors of counsel, but not (usually) formally trained counsellors, magazine advisors worked with the new languages and concepts of psychological expertise and disseminated them to avid readers.Across this period, problem pages demonstrated greater openness towards sex and displacement of morality from external standards to the individual. However, advisors also continued to emphasise self-control and responsibility, and to provide practical guidance that took at best a superficially psychological veneer. These trends were underpinned by a model of sex as an essential part of loving, stable relationships, and the (largely unexpressed) notion that such relationships were essential to social functioning. In the woman’s world of the magazine, before and beyond the 1980s, the problem page does not show the rise of individualism or the pursuit of pleasure above all else.
Association between statin therapy and the risk of stroke in patients with moyamoya disease: a nationwide cohort study
Authors: Yoo Joonsang , Jeon Jimin , Baik Minyoul , Kim Jinkwon 
Published: December 2022

Background and objectiveKnowledge regarding the pharmacological treatment for moyamoya disease (MMD), a chronic and progressive cerebrovascular disease conferring greater stroke risk, is limited. In the present study, whether statin therapy is associated with a reduced risk of stroke in patients with MMD was investigated.MethodsThis was a retrospective cohort study in which the occurrence of stroke in patients with newly diagnosed MMD was investigated using the nationwide health insurance database in Korea from January 2007 to March 2021. A multivariable Cox proportional hazards regression model was constructed for stroke, in which statin therapy after MMD diagnosis was treated as a time-dependent variable. Adjustment was done for sex, age, presence of comorbidities, concurrent stroke, revascularisation surgery and treatment with antiplatelets.ResultsThe present study included 13 373 newly diagnosed patients with MMD; 40.8% had a concurrent stroke at the time of MMD diagnosis. During the mean follow-up of 5.1±3.3 years, 631 patients (4.7%) suffered a stroke event (haemorrhagic stroke: 458 patients, ischaemic stroke: 173 patients). Statin therapy after MMD diagnosis was significantly associated with a reduced risk of stroke (adjusted HR 0.74; 95% CI 0.60 to 0.91, p=0.004). In the secondary outcome analysis, the risk of haemorrhagic stroke (adjusted HR 0.74; 95% CI 0.58 to 0.95, p=0.018) and ischaemic stroke (adjusted HR 0.75; 95% CI 0.52 to 1.08, p=0.124) were reduced with the statin treatment. Taking statins was also associated with a lower risk of all-cause mortality (adjusted HR 0.47; 95% CI 0.33 to 0.67, p<0.001).ConclusionIn patients with MMD, statin therapy was associated with a reduced risk of subsequent stroke. The findings indicate statin treatment may be beneficial for patients with MMD, however the results should be confirmed in randomised controlled trials.
Transmission estimation at the quantum Cramér-Rao bound with macroscopic quantum light
Authors: Woodworth Timothy S. , Hermann-Avigliano Carla , Chan Kam Wai Clifford , Marino Alberto M. 
Published: December 2022

AbstractThe field of quantum metrology seeks to apply quantum techniques and/or resources to classical sensing approaches with the goal of enhancing the precision in the estimation of a parameter beyond what can be achieved with classical resources. Theoretically, the fundamental minimum uncertainty in the estimation of a parameter for a given probing state is bounded by the quantum Cramér-Rao bound. From a practical perspective, it is necessary to find physical measurements that can saturate this fundamental limit and to show experimentally that it is possible to perform measurements with the required precision to do so. Here we perform experiments that saturate the quantum Cramér-Rao bound for transmission estimation over a wide range of transmissions when probing the system under study with a continuous wave bright two-mode squeezed state. To properly take into account the imperfections in the generation of the quantum state, we extend our previous theoretical results to incorporate the measured properties of the generated quantum state. For our largest transmission level of 84%, we show a 62% reduction over the optimal classical protocol in the variance in transmission estimation when probing with a bright two-mode squeezed state with −8 dB of intensity-difference squeezing. Given that transmission estimation is an integral part of many sensing protocols, such as plasmonic sensing, spectroscopy, calibration of the quantum efficiency of detectors, etc., the results presented promise to have a significant impact on a number of applications in various fields of research.
Gravastar under the framework of braneworld gravity II: Effect of the Kuchowicz metric function
Authors: Ray Saibal , Ghosh Shounak , Sengupta Rikpratik 
Published: December 2022

In recent years, a class of compact objects called gravastars have drawn immense interest as regular solutions to end state stellar collapse. Since the energy density involved in collapse process is expected to be high, it is a natural choice to study such compact objects in context of modified gravity theories which reduce to General Relativity (GR) in the low energy regime. We have already framed a model of gravastar in such a modified gravity framework involving extra dimensional Randall–Sundrum (RS) single brane gravity [R. Sengupta, S. Ghosh, S. Ray, B. Mishra and S. K. Tripathy, Phys. Rev. D 102, 024037 (2020)]. As a sequel in this paper, we substantially improve our previous model by choosing the Kuchowicz function as one of the metric potentials, which leads to many new interesting results and physical features from our analysis as discussed in this paper. Also, we provide essential additional stability checks on our gravastar model to investigate the possibility of any instability creeping in due to the higher-dimensional framework. Our present improved gravastar model is found to clear all the stability checks successfully. Very interestingly, the static spherically symmetric matter distributions are found to accommodate both classes of solutions obeying and violating the modified energy conditions on the RS brane as we find in this work. We can conclude from our analysis that the Kuchowicz metric potential is very effective for describing regular solutions to compact objects at substantially high energies on the three-brane.
Unconditional self-acceptance among the psychology students of University X, Malaysia: the role of mattering, perceived social support and state self-esteem
Authors: Lim Alycia Jia Ee , Ishak Zahari , Prihadi Kususanto Ditto , Aziz Abdul 
Published: December 2022

<p>Unconditional self-acceptance (USA) is important for mental health. Studies reported that university students would develop the USA when they feel socially supported, included, and matter. Nevertheless, those factors are dependent on social feedbacks. Amidst the COVID-19 outbreak is, they had to follow the social distancing protocols and interact online with each other. This change might have altered the way they perceive the social support and mattering. It is hypothesized that these alterations predicted their USA through their perceived social support (PSS) and the sense of social inclusion (state self-esteem). To test the hypothesis, 214 young adults (85 men, 129 women), aged between 18 to 25 (M=22.80, SD=1.92) were asked to complete a demographic form and the scales of each variable. Students from University X, Malaysia were chosen as the population as they studied fully online when we started this study; unfortunately, the university went back to physical study before we managed to collect our target sample size. The results of Bootstrapping with 5,000 samples and 95% confidence interval showed that state self-esteem (SSE) fully mediated the relationship between mattering and USA, while PSS did not. Therefore, the hypothesis of serial mediation was not supported.</p>
Redescription of five species of Athelginae Codreanu & Codreanu, 1956 (Isopoda, Bopyridae), with new localities and new hosts
Authors: An Jianmei , Liu Yuelin , Luo Rong , Paulay Gustav 
Published: December 2022

Abstract
All members of the Athelginae are abdominal parasites of paguroid crabs. Five species of athelgines from the Florida Museum of Natural History are reported here, three from new localities and hosts. Allathelges pakistanensis Kazmi & Markham, 1999 is recorded from Oman, from the type host. Athelges caudalis Barnard, 1955 is recorded from the Philippines from a new host, Calcinus latens (Randall, 1840). Parathelges sp., closely resembling the Atlantic species P. tumidipes Markham, 1972, is recorded from the Federated States of Micronesia from Clibanarius corallinus (H. Milne Edwards, 1848). New specimens of Pseudostegias dulcilacuum Markham, 1982 and Parathelges aniculi (Whitelegge, 1897) are recorded from Thailand and the Philippines from known hosts. Keys to species of Pseudostegias, Parathelges and Athelges are provided, and recorded hosts and localities of all species of Athelges and Parathelges are summarized.
Redescription of Unicolax mycterobius (Vervoort, 1965) (Copepoda, Cyclopoida, Bomolochidae) recovered from Auxis thazard (Lacépède, 1800) (Pisces, Scombridae) in Japan
Authors: Izawa Kunihiko 
Published: December 2022

Abstract
Unicolax mycterobius (Vervoort, 1965) is redescribed based on specimens of both sexes recovered from the nasal cavity of the frigate tuna Auxis thazard (Lacépède, 1800) (Pisces, Scombridae) in Japan. This species possesses the lateral processes in the oral area.
Emotional Problems Arising during the First Trimester of Pregnancy
Authors: Ferrarello Susi 
Published: December 2022

Abstract
This paper proposes a phenomenological exploration of the first trimester of pregnancy. In this paper I have presented three core problems that might already appear in the first trimester of pregnancy: alienation, objectification, and loss of identity, which might cause emotional distress for the woman and further develop into depressive states. The goal of the paper is to indicate the kind of mindful approach we can use to reduce the impact of these problems.
The Recast EU Blue Card Directive: Towards a Level Playing Field to Attract Highly Qualified Migrant Talent to Work in the EU?
Authors: de Lange Tesseltje , Vankova Zvezda 
Published: December 2022

Abstract
This article discusses the recast Blue Card Directive (BCD) on the admission of highly qualified non-EU migrant workers. The recast Directive aims to facilitate employers in their demand of non-EU talent and enhances migrant workers’ rights. As this article demonstrates, challenges remain in view of the prerogative of Member States to maintain national schemes and benefit from wide discretion. We conclude that if Member States implement the recast restrictively, the recast BCD could be an example of ‘failing forward’, a next step in a continuous process failing to achieve the Commissions’ ambitions of harmonizing EU migration law. Yet, by engaging in a novel legislative approach which we coin ‘encapsulating harmonisation’ of EU and national migration law, the Commission manages to enhance the level playing field aimed for, especially on improving migrant workers’ rights. Whether the Recast BCD will indeed attract more highly qualified migrants to work in the EU, however, will depend on Member States’ implementation and their use of the discretion afforded by the BCD.
The EU Returns Agency: The Commissions’ Ambitious Plans and Their Human Rights Implications
Authors: Gkliati Mariana 
Published: December 2022

Abstract
The effective return of irregularly staying migrants is identified as an overriding objective in the New Pact on Migration and Asylum, while return operations are the fastest-growing activity of Frontex. Since the 2019 amendment of its Regulation, the agency has received a significant augmentation of its mandate and capacity in pre-return and return-related activities. This way, Frontex takes a centre-stage role in the Commission’s plan to intensify returns. This article fills the relevant gap in existing literature, updating our knowledge on the latest legislative developments in EU return operations and answering questions related to their human rights implications at a time when the scrutiny over Frontex is at its peak. The article discusses the human rights risks of these operations and the effectiveness of the available safeguards. This article is the product mainly of legal doctrinal research, i.e. the analysis of the relevant EU law and legal literature, along with civil society and institutional reports and other empirical documentation. At the same time, it also looks at quantitative data on the agency’s return activities from 2004 until 2019.
Carrying Inundation Blessings: A Discussion of Pilgrim Flask Amulets in Ancient Egypt
Authors: Kilroe Loretta 
Published: December 2022

Abstract
Pilgrim flasks were a ceramic form that first appeared in Egypt in the Eighteenth Dynasty. A small quantity of faience amulets in the shape of pilgrim flasks are known in several museum collections, but have not been studied in detail. The amulets are standardized in material and shape and, based on the limited contextual information, likely reflect a specific aspect of local belief, especially since their worn surface and bail for stringing suggests they were worn and touched regularly. It is suggested that these amulets are chronologically restricted and date between the Third Intermediate Period and Late Period, and are related to the contemporary appearance of New Year’s Flasks – a type of pilgrim flask predominantly made in faience and thought to be for celebration of the Nile inundation. By presenting a macro-focus on a little-known amulet type, it is hoped this study will expand our understanding of religious ideology, symbolic meaning, and the changing socio-cultural context in the Third Intermediate Period.
The Art of an Ecosystem
Authors: Looser Thomas D. 
Published: December 2022

Abstract
Anyone interested in the ecosystems of the Pacific Islands knows that at the most practical level, the “actual reality of things” is not ideal. In Hawai‘i, as elsewhere in the Pacific Islands, water is a central case in point. Therefore, it is perhaps unsurprising that the upcoming centennial of the Ala Wai canal in Waikīkī, Oʻahu is taking on new significance. Built in 1921, the canal was designed not only to help control flooding, but also to drain the area that would become Waikīkī; controlling water was then a military goal, but also a real estate project. Artist, architect, and urban planner Sean Connelly is one critic of this logic, arguing for the recovery of a more traditional approach to water management—and life—as figured by the Indigenous ahupua‘a system.