bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sugars in Multicomponent Reactions: A Toolbox for Diversity-Oriented Synthesis
Authors: Maikhuri Vipin K. , Verma Vineet , Mathur Divya , Prasad Ashok K. , Chaudhary Ankita , Kumar Rajesh 
Published: March 2023

AbstractMulticomponent reactions (MCRs) cover strategically employed chemical transformations that incorporate three or more reactants in one pot leading to a functionalized final product. Thus, it is an ideal tool to achieve high levels of complexity, diversity, yields of desired products, atom economy, and reduced reaction times. Sugars belong to the class of naturally occurring compounds with fascinating applications in the field of drug discovery due to the presence of various hydroxy groups and well-defined stereochemistry. However, their potential in MCRs has been realized only recently. This account describes recent advances in the synthesis of sugar-derived heterocycles synthesized by MCRs. We hope to encourage the synthetic and medicinal chemistry community to apply this powerful MCR chemistry to generate novel glycoconjugate challenges.1	Introduction2	Synthesis of Various Functionalized Sugar Compounds2.1	Passerini and Ugi Multicomponent Reactions2.2	Petasis Reaction2.3	Hantzsch Reaction2.4	Domino Ferrier–Povarov Reaction2.5	Marckwald Reaction2.6	Groebke–Blackburn–Bienaymé (GBB) Reaction2.7	Prins–Ritter Reaction2.8	Debus–Radziszewski Imidazole Synthesis Reaction2.9	Mannich Reaction2.10	A3-Coupling Reaction2.11	[3+2]-Cycloaddition Reactions2.12	Miscellaneous Reactions3	Conclusion
Imaging Recommendations for Diagnosis, Staging, and Management of Carcinoma of Unknown Origin (Lymph Node, Pulmonary, Liver, Skeletal, and Brain) with Emphasis on the Current Position of PET-CT in Carcinoma of Unknown Origin (CUP)
Authors: Loharkar Sarvesh , Basu Sandip 
Published: March 2023

AbstractMost of the established guidelines mention and recommend the use of FDG-PET/CT (fluorodeoxyglucose positron emission tomography/computed tomography) in carcinoma of unknown primary (CUP) especially in head–neck squamous cell carcinoma; as described in this article, this forms a powerful one-stop shop in diagnosing and staging modality and has multiple applications in difficult situations of CUPs. Although not used as a screening modality, FDG-PET/CT is recommended as the primary imaging modality in the evaluation of primary, staging, and response evaluation for CUP with histology known to demonstrate FDG avidity, especially patients presenting with lymph nodal disease. It should be remembered that many histological types do not concentrate on FDG and FDG also shows false-positive results in many other conditions like infection-inflammation; however, at the same time, it delivers high negative predictive values, an important consideration when employing FDG-PET/CT in the CUP scenario. SSTR-based PET/CT plays a pivotal role in primary diagnosis, staging, therapy planning, and response assessment in CUPs with neuroendocrine tumor or neuroendocrine neoplasm histology. The last two decades has witnessed great advancement in PET instrumentation and radiopharmaceuticals: particularly techniques like PET/magnetic resonance imaging and radiopharmaceuticals like FAPI (fibroblast-activation protein inhibitor)-based PET tracers. Hence, the role of PET/CT is expected to expand its reach in the coming years in line with accruing literature evidence, thereby upgrading its role and reliability in oncological practice strategies.
Clostridium difficile in Oncology Patients—Review of Diagnosis and Management in the Indian Setting
Authors: Prayag Parikshit S , Patwardhan Sampada A , Panchakshari Shweta P , Prayag Amrita P 
Published: March 2023

Abstract
Clostridoides (formerly Clostridium) difficile (C. difficile) is a toxin-producing, gram-positive anaerobic bacillus, commonly implicated in antibiotic-associated diarrhea and pseudomembranous colitis. The true burden of C. difficile infection is unclear in India, as it is likely underdiagnosed and underreported. Its incidence is much higher in oncology patients where it can contribute significantly to morbidity and mortality. There are several challenges in the Indian setting, including lack of uniform availability of testing infrastructure, as well as therapy. Oncology patients further present with a unique set of challenges. This article will review the approach to diagnosis and management of C. difficile-associated diarrhea in India, with a focus on oncology patients.
Imaging Recommendations for Diagnosis, Staging, and Management of Soft Tissue Sarcomas
Authors: Lupton Kenneth , Salins Manjusha , Pass Bill , Negi Raj , Gupta Harun 
Published: March 2023

AbstractSoft tissue lesions are a wide range of tumors of mesenchymal cell origin, occurring anywhere in the body with a vast number of histological subtypes both benign and malignant. These are common in clinical practice and vast majority are benign. This article focuses on soft tissue sarcoma of the trunk and extremities and discusses their imaging guidelines.
Building on the Academic Legacy of Pat Stelmachowicz and other Pioneers in Developmental Psychoacoustics and Pediatric Audiology: The Children's English/Spanish Speech Recognition Test (ChEgSS)
Authors: Leibold Lori J. , Calandruccio Lauren , Buss Emily 
Published: March 2023

AbstractBasic research investigating auditory development often has implications for clinical diagnosis and treatment of hearing loss in children, but it can be challenging to translate those findings into practice. Meeting that challenge was a guiding principle of Pat Stelmachowicz's research and mentorship. Her example inspired many of us to pursue translational research and motivated the recent development of the Children's English/Spanish Speech Recognition Test (ChEgSS). This test evaluates word recognition in noise or two-talker speech, with target and masker speech produced in either English or Spanish. The test uses recorded materials and a forced-choice response, so the tester need not be fluent in the test language. ChEgSS provides a clinical measure of masked speech recognition outcomes for children who speak English, Spanish, or both, including estimates of performance in noise and two-talker speech, with the goal of maximizing speech and hearing outcomes for children with hearing loss. This article highlights several of Pat's many contributions to pediatric hearing research and describes the motivation and development of ChEgSS.
Use of Wideband Acoustic Immittance in Neonates and Infants
Authors: AlMakadma Hammam , Aithal Sreedevi , Aithal Venkatesh , Kei Joseph 
Published: March 2023

AbstractWith widespread agreement on the importance of early identification of hearing loss, universal newborn hearing screening (UNHS) has become the standard of care in several countries. Despite advancements in screening technology, UNHS and early hearing detection and intervention programs continue to be burdened by high referral rates of false-positive cases due to temporary obstruction of sound in the outer/middle ear at birth. A sensitive adjunct test of middle ear at the time of screening would aid in the interpretation of screening outcomes, minimize unnecessary rescreens, and prioritize referral to diagnostic assessment for infants with permanent congenital hearing loss. Determination of middle ear status is also an important aspect of diagnostic assessment in infants. Standard single-frequency tympanometry used to determine middle ear status in infants is neither efficient nor accurate in newborns and young infants. A growing body of research has demonstrated the utility of wideband acoustic immittance (WAI) testing in both screening and diagnostic settings. Wideband power absorbance (WBA), a WAI measure, has been shown to be more sensitive than tympanometry in the assessment of outer/middle ear function in newborns. Furthermore, age-graded norms also support successful application of WBA in young infants. Despite its merits, uptake of this technology is low among pediatric audiologists and hearing screening health workers. This report describes normative data, methods for assessment and interpretation of WBA, test–retest variations, and other factors pertinent to clinical use of WAI in newborns and infants. Clinical cases illustrate the use of WAI testing in newborn and infant hearing assessment.
Effect of Si/Al addition on magnetic properties of Fe-Co alloy
Authors: Sato Takamasa , Takabayashi Hiroyuki 
Published: March 2023

Fe-Co alloys are promising materials for high power density motors, since they have higher Bs than Fe-Si steels which are most commonly used as the motor cores. It is known, however, that the Fe-Co alloys generally have poor workability due to an existence of the brittle phase, ordered B2. In this study, effects of Co content and Si/Al addition with the Fe-Co alloys on the workability and magnetic properties were investigated. The neutron diffraction measurements of the Fe-Co alloys with different Co contents of 5, 18, 27, and 49 mass% were first conducted to know the existence of the ordered B2 phase. The result showed that the B2 phase was observed in the Fe-Co alloys with Co contents of 27 and 49 mass%, while the alloys with 5 and 18 mass% did not contain it, which suggests the latter two alloys have the better workability. Then, we checked the effect of Si/Al addition on the magnetic properties of the 82Fe-18Co alloy, and found that the co-addition of Si/Al reduce the coercivity, Hc to about 60 A/m and iron loss to less than 170 W/kg while maintaining a high B value at 30 000 A/m above 2.2 T.
An onomasiological competition
Authors: Glebkin Vladimir 
Published: March 2023

Abstract
An onomasiological competition between lexical units, in which they compete to name a certain object (phenomenon,
process, event, etc.), rarely attracts the attention of linguists, mainly due to an interdisciplinary nature of such research and
the lack of a developed methodology for that. In this article, the author presents a case study of the onomasiological competition
between constructions of otkryvat' butylku (‘to open a bottle’) and otkuporivat' butylku (‘to
uncork a bottle’) during the 19th and 20th centuries and reveals sociocultural factors influencing the course and result of this
competition. Based on this analysis, a few sociocultural scenarios that should be taken into consideration in research of various
types of onomasiological competition are presented.
Constructing identity through code choice and code-switching
Authors: Ali Farah 
Published: March 2023

Abstract
With the presence of Catalan, Spanish, and a variety of migrant languages, multilingualism in Catalonia extends across the region and is a regular practice for native-born and migrant residents alike. This study examines language use and its relationship to identity construction among first and second-generation Muslim women immigrants in Barcelona. Data was collected from 34 female informants in Barcelona, all of whom identified as first or second-generation Muslim. Data consisted of questionnaires and interviews which were designed to learn about the informants’ linguistic background as well as the extent to which they used Spanish, Catalan and their native/heritage language(s). As a further case study, specific instances of code-switching among the South Asian Urdu-speaking informants were examined. Results point to a generational divide in terms of domains of use. However, informants demonstrated a greater tendency towards multilingual language use rather than restricting themselves to single language use in specific domains, a reflection of informants’ self-reported code-switching practices, which were found to be a widely accepted communicative tool that serves an array of socio-pragmatic functions.
A mechanism for dark matter and dark energy in the theory of causal fermion systems
Authors: Finster Felix , Isidro José M 
Published: March 2023

Abstract
It is shown that the theory of causal fermion systems gives rise to a novel mechanism for dark matter and dark energy. This mechanism is first worked out for cubical subsets of Minkowski space with periodic boundary conditions. Then it is studied in Friedmann–Lemaître–Roberson–Walker spacetimes. The magnitude of the effect scales like one over the lifetime of the Universe squared. In contrast to most models of dark matter and dark energy, our mechanism does not postulate any new particles. Instead, it is a result of the collective behavior of all the wave functions which form the Dirac sea, needed in order to arrange correlated initial and end quantum states of the Universe.
Spin filters based on two-dimensional materials Co2Si and Cu2Si
Authors: Meng Yexuan , Jiang Liwei , Zheng Yisong 
Published: March 2023

Abstract
Spintronic devices have several advantages compared with conventional electronic devices, including non-volatility, faster data processing speed, higher integration densities, less electric power consumption and so on. However, we still face challenges for efficiently generating and injecting pure spin polarized current. In this work, we utilize two kinds of two-dimensional materials Co2Si and Cu2Si with both lattice match and band match to construct devices and then research their spin filter efficiency. The spin filter efficiency can be improved effectively either by an appropriate gate voltage at Co2Si region, or by series connection. In both cases the filter efficiencies are much larger than two-dimensional prepared Fe3GeTe2 spin valve and ferromagnetic metallic chairlike O-graphene-H. Also at a quite small bias, we obtain a comparable spin polarized current as those obtained in Fe3GeTe2 spin valve and O-graphene-H obtained at a much larger bias.
Continuous-wave single-frequency holmium-doped fiber laser based on saturable absorber
Authors: Vladimirskaya A D , Kamynin V A , Lobach I A , Kablukov S I 
Published: March 2023

Abstract
The single-frequency holmium-doped fiber laser with spectral filtration based on a dynamics filter formed in heavily holmium-doped fiber is presented. The continuous wave lasing on a single longitudinal mode in the spectral region of 2.1 μm with an output power of 1.6 mW is shown when the filtering fiber is cooled with liquid nitrogen. The optical signal-to-noise ratio and the relative intensity noise were more than 30 dB and — 62.8 dB Hz−1, respectively. The developed source can be used for gas spectroscopy as well as for remote atmosphere sensing of such gases as carbon dioxide, nitric oxide, ammonia, carbon monoxide and others.
Will biomimetic robots be able to change a hivemind to guide honeybees’ ecosystem services?
Authors: Lazic Dajana , Schmickl Thomas 
Published: March 2023

Abstract
We study whether or not a group of biomimetic waggle dancing robots is able to significantly influence the swarm-intelligent decision making of a honeybee colony, e.g. to avoid foraging at dangerous food patches using a mathematical model. Our model was successfully validated against data from two empirical experiments: one examined the selection of foraging targets and the other cross inhibition between foraging targets. We found that such biomimetic robots have a significant effect on a honeybee colony’s foraging decision. This effect correlates with the number of applied robots up to several dozens of robots and then saturates quickly with higher robot numbers. These robots can reallocate the bees’ pollination service in a directed way towards desired locations or boost it at specific locations, without having a significant negative effect on the colony’s nectar economy. Additionally, we found that such robots may be able to lower the influx of toxic substances from potentially harmful foraging sites by guiding the bees to alternative places. These effects also depend on the saturation level of the colony’s nectar stores. The more nectar is already stored in the colony, the easier the bees are guided by the robots to alternative foraging targets. Our study shows that biomimetic and socially immersive biomimetic robots are a relevant future research target in order to support (a) the bees by guiding them to safe (pesticide free) places, (b) the ecosystem via boosted and directed pollination services and (c) human society by supporting agricultural crop pollination, thus increasing our food security this way.
Liposomes loaded with quercetin for resolution of lung inflammation in a lipopolysaccharide-induced mouse model of sepsis
Authors: Zhai Zhiqi , Fu Yue , Zhang Xinyue , Zhang Yi , Zhou Chao , Huang Xiaojia , Deng Linhong 
Published: March 2023

Abstract
Quercetin (QU) has been widely used as a dietary supplement and proved useful to treat lung diseases. However, the therapeutic potential of QU may be restricted because of its low bioavailability and poor water solubility. In this study, we investigated the effects of developed QU-loaded liposomes on macrophage-mediated lung inflammation. In vivo, a mouse model of sepsis induced by lipopolysaccharide challenge was used to detect the anti-inflammatory effects of liposomal QU. Hematoxylin/eosin staining and immunostaining were utilized to reveal pathological damage and leukocyte infiltration into the lung tissues. Quantitative reverse transcription-polymerase chain reaction and immunoblotting were used to determine cytokine production in the mouse lungs. In vitro, mouse RAW 264.7 macrophages were treated with free QU and liposomal QU. Cell viability assay and immunostaining were utilized to detect cytotoxicity and distribution of QU in the cells. The in vivo results showed that liposomal encapsulation promoted the inhibitory effects of QU on lung inflammation. Liposomal QU decreased mortality in septic mice with no obvious toxicity on vital organs. Mechanistically, the anti-inflammatory effects of liposomal QU were associated with inhibition of nuclear factor-kappa B-dependent cytokine production and inflammasome activation in macrophages. Collectively, the results showed that QU liposomes mitigated lung inflammation in septic mice through inhibition of macrophage inflammatory signaling.
Scattering of aggregated multi-layered biological cells by Bessel beams
Authors: Bai Jing , Liu Xuan , Ge Cheng-Xian , Wu Zhen-Sen , Zhang Xiao-Xiao 
Published: March 2023

Abstract
Interactions between collective multi-layered cells and an off-axis high-order Bessel beam (HOBB) are investigated. The generalized Lorenz-Mie theory is applied to derive the expansion of HOBB. Based on the additional theorem, multiple scattering of collective multi-layered nanoparticles is obtained by considering the tangential continuous boundary conditions. The present theory and codes are proven to be effective by comparing with the simulations obtained from the computer simulation technology (CST) software. Numerical results concerning the effects of beam order, beam conical angle, spherical layer number, core radius and outer layer radius, outer layer refractive index and the spherical number on the scattering of various types of aggregated multi-layered particles are displayed in detail, which may provide critical support for analytically understanding the optical scattering characteristics of aggregated multi-layered biological cells of complex shapes and may find important applications in manipulating multi-layered biological structures.
A population-based retrospective cohort study of end-of-life emergency department visits by people with dementia: multilevel modelling of individual- and service-level factors using linked data
Authors: Williamson Lesley E , Leniz Javiera , Chukwusa Emeka , Evans Catherine J , Sleeman Katherine E 
Published: March 2023

AbstractBackgroundemergency department (ED) visits have inherent risks for people with dementia yet increase towards the end-of-life. Although some individual-level determinants of ED visits have been identified, little is known about service-level determinants.Objectiveto examine individual- and service-level factors associated with ED visits by people with dementia in the last year of life.Methodsretrospective cohort study using hospital administrative and mortality data at the individual-level, linked to health and social care service data at the area-level across England. The primary outcome was number of ED visits in the last year of life. Subjects were decedents with dementia recorded on the death certificate, with at least one hospital contact in the last 3 years of life.Resultsof 74,486 decedents (60.5% women; mean age 87.1 years (standard deviation: 7.1)), 82.6% had at least one ED visit in their last year of life. Factors associated with more ED visits included: South Asian ethnicity (incidence rate ratio (IRR) 1.07, 95% confidence interval (CI) 1.02–1.13), chronic respiratory disease as the underlying cause of death (IRR 1.17, 95% CI 1.14–1.20) and urban residence (IRR 1.06, 95% CI 1.04–1.08). Higher socioeconomic position (IRR 0.92, 95% CI 0.90–0.94) and areas with higher numbers of nursing home beds (IRR 0.85, 95% CI 0.78–0.93)—but not residential home beds—were associated with fewer ED visits at the end-of-life.Conclusionsthe value of nursing home care in supporting people dying with dementia to stay in their preferred place of care must be recognised, and investment in nursing home bed capacity prioritised.
The genome of the soybean gall midge (Resseliella maxima)
Authors: Melotto Gloria , Jones Megan W , Bosley Kathryn , Flack Nicole , Frank Lexi E , Jacobson Emily , Kipp Evan J , Nelson Sally , Ramirez Mauricio , Walls Carrie , Koch Robert L , Lindsey Amelia R I , Faulk Christopher 
Published: March 2023

Abstract
The cecidomyiid fly, soybean gall midge, Resseliella maxima Gagné, is a recently discovered insect that feeds on soybean plants in the Midwestern United States. R. maxima larvae feed on soybean stems that may induce plant death and can cause considerable yield losses, making it an important agricultural pest. From three pools of 50 adults each, we used long-read nanopore sequencing to assemble a R. maxima reference genome. The final genome assembly is 206 Mb with 64.88× coverage, consisting of 1,009 contigs with an N50 size of 714 kb. The assembly is high quality with a Benchmarking Universal Single-Copy Ortholog (BUSCO) score of 87.8%. Genome-wide GC level is 31.60%, and DNA methylation was measured at 1.07%. The R. maxima genome is comprised of 21.73% repetitive DNA, which is in line with other cecidomyiids. Protein prediction annotated 14,798 coding genes with 89.9% protein BUSCO score. Mitogenome analysis indicated that R. maxima assembly is a single circular contig of 15,301 bp and shares highest identity to the mitogenome of the Asian rice gall midge, Orseolia oryzae Wood-Mason. The R. maxima genome has one of the highest completeness levels for a cecidomyiid and will provide a resource for research focused on the biology, genetics, and evolution of cecidomyiids, as well as plant–insect interactions in this important agricultural pest.