bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin A deficiency among pregnant women in Ethiopia: a systematic review and meta-analysis
Authors: Eyeberu Addis , Getachew Tamirat , Tiruye Getahun , Balis Bikila , Tamiru Dawit , Bekele Habtamu , Abdurke Mohommed , Alemu Addisu , Dessie Yadeta , Shiferaw Kasiye , Debela Adera 
Published: June 2023

Abstract

Background
Vitamin A deficiency (VAD) during pregnancy is a public health challenge in low-income countries. There are inconsistent findings that can affect policy in planning appropriate intervention. This systematic review and meta-analysis were conducted to summarize the evidence in order to identify existing gaps and propose strategies to reduce VAD during pregnancy in Ethiopia.

Methods
This study included published and unpublished observational studies searched from different databases (PubMed, CINHAL [EBSCO], Embase, Google Scholar, Directory of Open Access Journals, Web of Sciences, MEDLINE, Cochrane Library, Scopus, Google Search and MedNar). Statistical analysis was conducted using Stata version 14 software. Heterogeneity and publication bias were assessed. Forest plots were used to present the pooled prevalence using the random effects model.

Results
A total of 37 618 pregnant women from 15 studies were included. The overall pooled prevalence of VAD was 29% (95% confidence interval 21 to 36) with I2=99.67% and p&lt;0.001. Socio-economic and sociodemographic factors were identified as affecting vitamin A deficiencies among pregnant women.

Conclusions
Nearly one-third of pregnant women in Ethiopia had VAD. Strengthening intervention modalities that aimed to increase the uptake of vitamin A–rich foods can avert VAD among pregnant women in Ethiopia.
Lack of fitness costs in dsRNA-resistant Leptinotarsa decemlineata ([Coleoptera]: [Chrysomelidae])
Authors: Pinto M M D , Ferreira dos Santos R , De Bortoli S A , Moar W , Jurat-Fuentes J L 
Published: June 2023

Abstract
The Colorado potato beetle, Leptinotarsa decemlineata (Say) ([Coleoptera]: [Chrysomelidae]), is the most important defoliator of solanaceous plants worldwide. This insect displays a notorious ability in adapting to biological and synthetic insecticides, although in some cases this adaptation carries relevant fitness costs. Insecticidal gene silencing by RNA interference is a novel mode of action pesticide against L. decemlineata that is activated by ingestion of a double stranded RNA (dsRNA) targeting a vital L. decemlineata gene. We previously reported laboratory selection of a &gt; 11,000-fold resistant strain of L. decemlineata to a dsRNA delivered topically to potato leaves. In this work, we tested the existence of fitness costs in this dsRNA-resistant colony by comparing biological parameters to the parental strain and an additional susceptible reference strain. Biological parameters included length of egg incubation period, number of eggs per clutch, egg viability, larval viability, length of larval and pupal periods, adult emergence, number of eggs laid per day, sex ratio, and adult longevity. Comparisons between the 3 beetle strains detected no fitness costs associated with resistance to dsRNA. This information is important to guide effective insect resistance management plans for dsRNA insecticides against L. decemlineata applied topically to potato leaves.
The MOSDEF-LRIS survey: detection of inflowing gas towards three star-forming galaxies at z ∼ 2
Authors: Weldon Andrew , Reddy Naveen A , Topping Michael W , Shapley Alice E , Du Xinnan , Price Sedona H , Sanders Ryan L , Coil Alison L , Mobasher Bahram , Kriek Mariska , Siana Brian , Rezaee Saeed 
Published: June 2023

ABSTRACT
We report on the discovery of cool gas inflows towards three star-forming galaxies at &lt;z&gt; ∼ 2.30. Analysis of Keck Low-Resolution Imaging Spectrometer spectroscopy reveals redshifted low-ionization interstellar (LIS) metal absorption lines with centroid velocities of 60–130 km s−1. These inflows represent some of the most robust detections of inflowing gas into isolated, star-forming galaxies at high redshift. Our analysis suggests that the inflows are due to recycling metal-enriched gas from previous ejections. Comparisons between the galaxies with inflows and a larger parent sample of 131 objects indicate that galaxies with detected inflows may have higher specific star formation rates (sSFRs) and star-formation-rate surface densities (ΣSFR). However, when additional galaxies without robustly detected inflows based on centroid velocity but whose LIS absorption line profiles indicate large red-wing velocities are considered, galaxies with inflows do not show unique properties relative to those lacking inflows. Additionally, we calculate the covering fraction of cool inflowing gas as a function of red-wing inflow velocity, finding an enhancement in high-sSFR binned galaxies, likely due to an increase in the amount of recycling gas. Together, these results suggest that the low detection rate of galaxies with cool inflows is primarily related to the viewing angle rather than the physical properties of the galaxies.
GMRT H i mapping of mid-infrared bright blue compact dwarf galaxies W1016+3754 and W2326+0608
Authors: Chandola Y , Tsai C W , Li D , Sengupta C , Ma Y Z , Zuo P 
Published: June 2023

ABSTRACT
We present the results from deep 21 cm H i mapping of two nearby Blue Compact Dwarf Galaxies (BCDGs), W1016+3754 and W2326+0608, using the Giant Metrewave Radio Telescope (GMRT). These BCDGs are bright in mid-infrared data and undergoing active star formation. With the GMRT observations, we investigate the role of cold neutral gas as the fuel resource of the current intensive star formation activity. Star formation in these galaxies is likely to be due to the infall of H i gas triggered by gravitational perturbation from nearby galaxies. The BCDG W2326+0608 and nearby galaxy SDSS J232603.86+060835.8 share a common H i envelope. We find star formation takes place in the high H i column density gas (≳1021 cm−2) regions for both BCDGs. The recent starburst and infall of metal-free gas have kept the metallicity low for the BCDG W1016+3754. The metallicity for W2326+0608 is higher, possibly due to tidal interaction with the nearby galaxy SDSS J232603.86+060835.8.
Extreme broad He ii emission at high and low redshifts: the dominant role of VMS in NGC 3125-A1 and CDFS131717
Authors: Wofford Aida , Sixtos Andrés , Charlot Stephane , Bruzual Gustavo , Cullen Fergus , Stanton Thomas M , Hernández Svea , Smith Linda J , Hayes Matthew 
Published: June 2023

ABSTRACT
Super star cluster (SSC) A1 ($3.1\times 10^5\, \mathrm{M}_\odot$) in NGC 3125 has one of the strongest ($EW=4.6\pm 0.5\,$ Å) broad ($FWHM=1131\pm 40\,$ km s−1) He ii λ1640 emission lines in the nearby universe and constitutes an important template for interpreting observations of extreme He ii emitters out to redshifts of z ∼ 2 – 3. We use Cosmic Origins Spectrograph (COS) observations of A1 to show that there is no significant contamination of the He ii line with nebular emission and that the line is redshifted by 121 ± 17 km s−1 relative to ISM lines. We compare the COS G130M + G160M observations of A1 to recent binary BPASS and single-star Charlot & Bruzual (C&B) simple stellar population (SSP) models with very massive stars (VMS) of up to $300\, \mathrm{M}_\odot$. On the other hand, we suggest why BPASS models fail to reproduce A1’s He ii emission. On the other hand, a C&B model with Z = 0.008, age = 2.2 Myr, and VMS approaching the Eddington limit provides an excellent fit to the He ii emission and fits reasonably well C iii λ1175, N v λλ1238, 1241, and C iv λλ1548, 1551. We present O v λ1371 line-profile predictions showing that this line constitutes an important tracer of youth and VMS in galaxies. Finally, we discuss the presence of VMS in CDFS131717, a highly star-forming low-metallicity galaxy located at z = 3.071, which has a tentative detection of O v absorption and strong broad He ii emission. These features are rare and hint to the presence of short-lived VMS in the galaxy. Our results show the effect of the latest developments of stellar wind theory and the importance of accounting for VMS in models.
DenseLens – Using DenseNet ensembles and information criteria for finding and rank-ordering strong gravitational lenses
Authors: Nagam Bharath Chowdhary , Koopmans Léon V E , Valentijn Edwin A , Kleijn Gijs Verdoes , de Jong Jelte T A , Napolitano Nicola , Li Rui , Tortora Crescenzo 
Published: June 2023

ABSTRACT
Convolutional neural networks (CNNs) are the state-of-the-art technique for identifying strong gravitational lenses. Although they are highly successful in recovering genuine lens systems with a high true-positive rate, the unbalanced nature of the data set (lens systems are rare), still leads to a high false positive rate. For these techniques to be successful in upcoming surveys (e.g. with Euclid) most emphasis should be set on reducing false positives, rather than on reducing false negatives. In this paper, we introduce densely connected neural networks (DenseNets) as the CNN architecture in a new pipeline-ensemble model containing an ensemble of classification CNNs and regression CNNs to classify and rank-order lenses, respectively. We show that DenseNets achieve comparable true positive rates but considerably lower false positive rates (when compared to residual networks; ResNets). Thus, we recommend DenseNets for future missions involving large data sets, such as Euclid, where low false positive rates play a key role in the automated follow-up and analysis of large numbers of strong gravitational lens candidates when human vetting is no longer feasible.
Nanopore sensing reveals a preferential pathway for the co-translocational unfolding of a conjugative relaxase–DNA complex
Authors: Valenzuela-Gómez Fernando , Arechaga Ignacio , Rodríguez-Larrea David , Cabezón Elena 
Published: June 2023

Abstract
Bacterial conjugation is the main mechanism for the dissemination of antibiotic resistance genes. A single DNA strand of the conjugative plasmid is transferred across bacterial membranes covalently bound to a large multi-domain protein, named relaxase, which must be unfolded to traverse the secretion channel. Two tyrosine residues of the relaxase (Y18 and Y26 in relaxase TrwC) play an important role in the processing of conjugative DNA. We have used nanopore technology to uncover the unfolding states that take place during translocation of the relaxase–DNA complex. We observed that the relaxase unfolding pathway depends on the tyrosine residue involved in conjugative DNA binding. Transfer of the nucleoprotein complex is faster when DNA is bound to residue Y18. This is the first time in which a protein–DNA complex that is naturally translocated through bacterial membranes has been analyzed by nanopore sensing, opening new horizons to apply this technology to study protein secretion.
Pancreatic Cancer and its Attributable Risk Factors in East Asia, Now and Future
Authors: Ren Kuiwu , Liu Chunlong , He Ziqiang , Wu Panpan , Zhang Jian , Yang Rui , Cui Tao , Song Kun , Cheng Di , He Kui , Yu Jiangtao 
Published: June 2023

Abstract

Background
The disease burden of pancreatic cancer in East Asia is at a high level, but the epidemiological characteristics of pancreatic cancer in the region have not been systematically studied.

Method
Joinpoint analysis was used to identify average annual percentage change (AAPC) and annual percentage change (APC) in mortality. Age-period-cohort models were used to analyze age-period cohort effects across countries. Bayesian age-period-cohort (BAPC) analysis was used to project the burden of disease for 2020-2030.

Results
Pancreatic cancer mortality in males in Japan (2012-2019, APC = −0.97) and Korea (2012-2019, APC = −0.91) has shown a decreasing trend since 2012 (P &lt; .05). However, China (2016-2019, APC = 3.21), Mongolia (2015-2.019, APC = 2.37), and North Korea (2012-2019, APC = 0.47) showed a significant increase in pancreatic cancer in both genders (P &lt; .05). Risk factors for pancreatic cancer in East Asia remained largely stable between 2010 and 2019. Mortality of pancreatic cancer due to smoking began to decline in areas with high socio-demographic index (SDI), and mortality of pancreatic cancer due to high body mass index and high fasting plasma glucose increased with SDI. The age-standardized mortality for pancreatic cancer in Chinese males is expected to exceed that of Japan and South Korea by 2030, but the disease burden of pancreatic cancer in Japan and South Korea remains at extremely high levels.

Conclusion
Economically developed countries are beginning to show a decreasing trend in the burden of pancreatic cancer disease, and developing countries are experiencing a rapid increase in the age-standardized death rate (ASDR) of pancreatic cancer.
Genome-wide association study unveils ascorbate regulation by PAS/LOV PROTEIN during high light acclimation
Authors: Aarabi Fayezeh , Ghigi Andrea , Ahchige Micha Wijesingha , Bulut Mustafa , Geigenberger Peter , Neuhaus H Ekkehard , Sampathkumar Arun , Alseekh Saleh , Fernie Alisdair R 
Published: June 2023

Abstract
Varying light conditions elicit metabolic responses as part of acclimation with changes in ascorbate levels being an important component. Here, we adopted a genome-wide association-based approach to characterize the response in ascorbate levels on high light (HL) acclimation in a panel of 315 Arabidopsis (Arabidopsis thaliana) accessions. These studies revealed statistically significant SNPs for total and reduced ascorbate under HL conditions at a locus in chromosome 2. Ascorbate levels under HL and the region upstream and within PAS/LOV PROTEIN (PLP) were strongly associated. Intriguingly, subcellular localization analyses revealed that the PLPA and PLPB splice variants co-localized with VITAMIN C DEFECTIVE2 (VTC2) and VTC5 in both the cytosol and nucleus. Yeast 2-hybrid and bimolecular fluorescence complementation analyses revealed that PLPA and PLPB interact with VTC2 and that blue light diminishes this interaction. Furthermore, PLPB knockout mutants were characterized by 1.5- to 1.7-fold elevations in their ascorbate levels, whereas knockout mutants of the cry2 cryptochromes displayed 1.2- to 1.3-fold elevations compared to WT. Our results collectively indicate that PLP plays a critical role in the elevation of ascorbate levels, which is a signature response of HL acclimation. The results strongly suggest that this is achieved via the release of the inhibitory effect of PLP on VTC2 upon blue light illumination, as the VTC2-PLPB interaction is stronger under darkness. The conditional importance of the cryptochrome receptors under different environmental conditions suggests a complex hierarchy underpinning the environmental control of ascorbate levels. However, the data we present here clearly demonstrate that PLP dominates during HL acclimation.
Women’s Words and the Words of Women in the Oxford English Dictionary
Authors: Williams David-Antoine 
Published: June 2023

Abstract
This article explores datasets curated from the citation evidence in successive editions and revisions of the Oxford English Dictionary (1884–2022), which have been annotated to reflect the gender of the authors and other bibliographical metadata. This exploration aims both to supplement the historical account of the dictionary’s uses of female-authored quotation sources, correcting and elaborating some figures which have previously been reported, and to provide a contemporary account of women’s representation in OED Online, using the revision published in June 2022. In seeking to establish a more objective and empirical basis for judging ‘representativeness’, I treat the OED both as a self-contained bibliographical and lexicographical work, and comparatively, against other comprehensive or very large bibliographical corpora, namely the Garside et al. surveys of early English novels, the Library of Congress Catalog, and the HathiTrust Digital Library. The OED data studied here represents a significant (if restricted) subset, rather than a representative sample, of the OED corpus as a whole: modern (post-1700) quotations from books appearing with their author’s name in the OED evidence are considered. While this approach does not claim to make an objectively complete tally of every woman-authored quotation collected in the OED, it does enable a more detailed and accurate account than has previously been possible, and allows for a number of consistent cross-comparisons. A companion document of Supplementary Data & Notes, available at The Review of English Studies online, describes in technical terms how the data was compiled and the processes and principles by which it was annotated.
An exploration of marks/injuries related to BDSM sexual experiences
Authors: Drouin Michelle , Hernandez Ellis , Machette Anthony , Garcia Justin R , Boyd Ryan L 
Published: June 2023

Abstract

Background
Despite its growing prevalence, BDSM practice (bondage, discipline, dominance, submission, and sadomasochism) is still stigmatized, and little is known about the physical marks and injuries that individuals sustain from consensual BDSM-related activities.

Aim
In this exploratory study, we examined BDSM sexual experiences and the physical marks and injuries resulting from these experiences in a convenience sample of 513 US adults.

Methods
We examined the extent to which individuals at various stages of BDSM exploration engage with different types of BDSM and kink behaviors, along with the frequency with which they communicate about, inflict, and receive physical marks from these activities.

Outcomes
Our main outcome measures were intentional and unintentional marks sustained from BDSM-related activities, BDSM experiences, and the use of safe words.

Results
Results revealed that BDSM marks and injuries are common and quite varied (from small scratches to very large bruises) and unintentional and intentional marks differ in terms of typical size, place on body, and severity of injury. Additionally, BDSM experience is positively associated with the use of safe words and marking behaviors.

Clinical Translation
Disclosure of marks and injuries, intentional and unintentional, may be improved if health care providers are aware of, and make efforts to reduce stigma surrounding, BDSM and rough sex activity.

Strengths and Limitations
The findings of this study must be interpreted with acknowledgment of the limitations that it was a survey study with a convenience sample. However, as one of the few studies exploring the marks and injuries sustained from BDSM activities, the exploration of intentional and unintentional marks sustained provides a critical starting point for future examination of BDSM consequences that intersect with health care and the law.

Conclusion
Marks and injuries from BDSM-related activities are common, and despite the greater use of safe words, practitioners with more BDSM experience inflict more marks than those with less BDSM experience.
Uses of Electronic Health Record Data to Measure the Clinical Learning Environment of Graduate Medical Education Trainees: A Systematic Review
Authors: Lees A. Fischer , Beni Catherine , Lee Albert , Wedgeworth Patrick , Dzara Kristina , Joyner Byron , Tarczy-Hornoch Peter , Leu Michael 
Published: June 2023

Purpose
This study systematically reviews the uses of electronic health record (EHR) data to measure graduate medical education (GME) trainee competencies.

Method
In January 2022, the authors conducted a systematic review of original research in MEDLINE from database start to December 31, 2021. The authors searched for articles that used the EHR as their data source and in which the individual GME trainee was the unit of observation and/or unit of analysis. The database query was intentionally broad because an initial survey of pertinent articles identified no unifying Medical Subject Heading terms. Articles were coded and clustered by theme and Accreditation Council for Graduate Medical Education (ACGME) core competency.

Results
The database search yielded 3,540 articles, of which 86 met the study inclusion criteria. Articles clustered into 16 themes, the largest of which were trainee condition experience (17 articles), work patterns (16 articles), and continuity of care (12 articles). Five of the ACGME core competencies were represented (patient care and procedural skills, practice-based learning and improvement, systems-based practice, medical knowledge, and professionalism). In addition, 25 articles assessed the clinical learning environment.

Conclusions
This review identified 86 articles that used EHR data to measure individual GME trainee competencies, spanning 16 themes and 6 competencies and revealing marked between-trainee variation. The authors propose a digital learning cycle framework that arranges sequentially the uses of EHR data within the cycle of clinical experiential learning central to GME. Three technical components necessary to unlock the potential of EHR data to improve GME are described: measures, attribution, and visualization. Partnerships between GME programs and informatics departments will be pivotal in realizing this opportunity.
ESAIC focused guideline for the use of cardiac biomarkers in perioperative risk evaluation
Authors: Lurati Buse Giovanna , Bollen Pinto Bernardo , Abelha Fernando , Abbott Tom E.F. , Ackland Gareth , Afshari Arash , De Hert Stefan , Fellahi Jean-Luc , Giossi Laure , Kavsak Peter , Longrois Dan , M’Pembele Rene , Nucaro Anthony , Popova Ekaterine , Puelacher Christian , Richards Toby , Roth Sebastian , Sheka Mootii , Szczeklik Wojciech , van Waes Judith , Walder Bernhard , Chew Michelle S. 
Published: June 2023

BACKGROUND
In recent years, there has been increasing focus on the use of cardiac biomarkers in patients undergoing noncardiac surgery.

AIMS
The aim of this focused guideline was to provide updated guidance regarding the pre-, post- and combined pre-and postoperative use of cardiac troponin and B-type natriuretic peptides in adult patients undergoing noncardiac surgery.

METHODS
The guidelines were prepared using Grading of Recommendations Assessment Development and Evaluation (GRADE) methodology. This included the definition of critical outcomes, a systematic literature search, appraisal of certainty of evidence, evaluation of biomarker measurement in terms of the balance of desirable and undesirable effects including clinical outcomes, resource use, health inequality, stakeholder acceptance, and implementation. The panel differentiated between three different scopes of applications: cardiac biomarkers as prognostic factors, as tools for risk prediction, and for biomarker-enhanced management strategies.

RESULTS
In a modified Delphi process, the task force defined 12 critical outcomes. The systematic literature search resulted in over 25,000 hits, of which 115 full-text articles formed the body of evidence for recommendations. The evidence appraisal indicated heterogeneity in the certainty of evidence across critical outcomes. Further, there was relevant gradient in the certainty of evidence across the three scopes of application. Recommendations were issued and if this was not possible due to limited evidence, clinical practice statements were produced.

CONCLUSION
The ESAIC focused guidelines provide guidance on the perioperative use of cardiac troponin and B-type natriuretic peptides in patients undergoing noncardiac surgery, for three different scopes of application.