bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exceptional population genomic homogeneity in the black brittle star Ophiocomina nigra (Ophiuroidea, Echinodermata) along the Atlantic-Mediterranean coast
Authors: Leiva Carlos , Pérez-Sorribes Laia , González-Delgado Sara , Ortiz Sandra , Wangensteen Owen S. , Pérez-Portela Rocío 
Published: July 2023

AbstractThe Atlantic-Mediterranean marine transition is characterised by strong oceanographic barriers and steep environmental gradients that generally result in connectivity breaks between populations from both basins and may lead to local adaptation. Here, we performed a population genomic study of the black brittle star,Ophiocomina nigra, covering most of its distribution range along the Atlantic-Mediterranean region. Interestingly,O. nigrais extremely variable in its coloration, with individuals ranging from black to yellow-orange, and different colour morphs inhabiting different depths and habitats. In this work, we used a fragment of the mitochondrialCOIgene and 2,374 genome-wide ddRADseq-derived SNPs to explore: (a) whether the different colour morphs ofO. nigrarepresent different evolutionary units; (b) the disruptive effects of major oceanographic fronts on its population structure; and (c) genomic signals of local adaptation to divergent environments. Our results revealed exceptional population homogeneity, barely affected by oceanographic fronts, with no signals of local adaptation nor genetic differentiation between colour morphs. This remarkable panmixia likely results from a long pelagic larval duration, a large effective population size and recent demographic expansions. Our study unveils an extraordinary phenotypic plasticity inO. nigra, opening further research questions on the ecological and molecular mechanisms underpinning coloration in Ophiuroidea.
The prevalence and predictors of geriatric giants in community-dwelling older adults: a cross-sectional study from the Middle East
Authors: Badrkhahan Seyedeh Zahra , Ala Moein , Fakhrzadeh Hossein , Yaghoobi Arash , Mirzamohamadi Sara , Arzaghi Seyed Masoud , Shahabi Sina , Sharifi Farshad , Ostovar Afshin , Fahimfar Noushin , Nabipour Iraj , Larijani Bagher , Shafiee Gita , Heshmat Ramin 
Published: July 2023

AbstractThe term “geriatric giants” refers to the chronic disabilities of senescence leading to adverse health outcomes. This study aimed to investigate the prevalence and predictors of geriatric giants in Southern Iran. The participants were selected from Bushehr city using a multistage cluster random sampling method. Demographic data were collected through interviews. Frailty, incontinence, immobility, depression, cognitive impairment, and malnutrition were measured by questionnaires and instruments. Finally, data from 2392 participants were analyzed. The prevalence of fecal incontinence was less than 1% among all participants and similar in men and women. In contrast, compared with men, women had higher prevalence of urinary incontinence (36.44% vs. 17.65%), depression (39.05% vs. 12.89%), anorexia and malnutrition (2.35% vs. 0.82%), immobility (8.00% vs. 2.5%), frailty (16.84 vs. 7.34), and pre-frailty (54.19 vs. 38.63%). The prevalence of dependence and cognitive impairment was also higher in women and considerably increased with the age of participants. In total, 12.07% of subjects were frail, and 46.76% were pre-frail. The prevalence of frailty exponentially increased in older age, ranging from 4.18% among those aged 60–64 years to 57.35% in those aged ≥ 80 years. Considering 95% confidence interval (CI), multivariate logistic regression revealed that low physical activity [odds ratio (OR) 31.73 (18.44–54.60)], cancer (OR 3.28 (1.27–8.44)), depression [OR 2.42 (1.97–2.98)], age [OR 1.11 (1.08–1.14)], waist circumference [OR 1.03 (1.01–1.06)], BMI [OR 1.07 (1.01–1.14)], MNA score [OR 0.85 (0.79–0.92)], polypharmacy [OR 2.26 (1.30–3.95)] and male gender [OR 0.63 (0.42–0.93)] were independently associated with frailty. White blood cell count (WBC), smoking, marital status, and number of comorbidities were not independently associated with frailty. Low physical activity was the strongest predictor of frailty, which may need more attention in geriatric care. Frailty, its predictors, and other components of geriatric giants were considerably more common among women and older ages.
Thermally tunable Dyakonov surface waves in semiconductor nanowire metamaterials
Authors: Moradi Mostafa 
Published: July 2023

AbstractThe development of engineered metamaterials has enabled the fabrication of tunable photonic devices capable of manipulating the characteristics of electromagnetic surface waves. Integration of semiconductors in metamaterials is a proven approach for creating thermally tunable metamaterials through temperature control of the semiconductor carrier density. In this paper, an interface consisting of an isotropic dielectric material as a cover and an indium antimonide (InSb) nanowire metamaterial as a substrate, is theoretically introduced to investigate the propagation conditions of Dyakonov surface waves in terahertz (THz) frequencies. Various temperature-dependent properties of Dyakonov surface waves in such a geometry is studied, including allowed THz regions, angular existence domain, dispersion relation, directionality, localization degree and figure of merit. The proposed configuration due to the presence of significant birefringence in InSb nanowire metamaterial, has potential applications in THz sensing, imaging and spectroscopy.
Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis
Authors: Yadavalli Chandra Sekhar , Upparahalli Venkateshaiah Sathisha , Kumar Sandeep , Kandikattu Hemanth Kumar , Oruganti Lokanatha , Kathera Chandra Sekhar , Mishra Anil 
Published: July 2023

AbstractThe current report describes a stepwise mechanistic pathway of NLRP3/caspase1/IL-18-regulated immune responses operational in eosinophilic esophagitis (EoE). We show that esophageal epithelial cells and macrophage-derived NLRP3 regulated IL-18 initiate the disease and induced IL-5 facilitates eosinophil growth and survival. We also found that A. fumigatus-exposed IL-18−/− mice or IL-18-neutralized mice are protected from EoE induction. Most importantly, we present that intravascular rIL-18 delivery to ΔdblGATA mice and CD2-IL-5 mice show the development of EoE characteristics feature like degranulated and intraepithelial eosinophils, basal cell hyperplasia, remodeling and fibrosis. Similarly, we show an induced NLRP3-caspase1-regulated IL-18 pathway is also operational in human EoE. Lastly, we present the evidence that inhibitors of NLRP3 and caspase-1 (MCC950, BHB, and VX-765) protect A. fumigatus- and corn-extract-induced EoE pathogenesis. In conclusion, the current study provides a new understanding by implicating NLRP3/caspase1-regulated IL-18 pathway in EoE pathogenesis. The study has the clinical significance and novel therapeutic strategy, which depletes only IL-18-responsive pathogenic eosinophils, not naïve IL-5-generated eosinophils critical for maintaining innate immunity.
Topological magnon-photon interaction for cavity magnonics
Authors: Lee Jongjun M. , Hwang Myung-Joong , Lee Hyun-Woo 
Published: July 2023

AbstractThe study of cavity magnonics and topological insulators has made significant advances over the past decade, however the possibility of combining the two fields is still unexplored. Here, we explore such connection by investigating hybrid cavity systems that incorporate both a ferromagnet and a topological insulator. We find that electrons in the topological surface state efficiently mediate the effective electric dipole coupling between the spin of the ferromagnet and the electric field of the cavity, in contrast with the conventional cavity magnonics theory based on magnetic dipole coupling. We refer to this coupling as topological magnon-photon interaction, estimating it one order of magnitude stronger than the conventional magnon-photon coupling, and showing that its sign can be manipulated. We discuss the potential of our proposed device to allow for scaling down and controlling the cavity system using electronics. Our results provide solid ground for exploring the functionalities enabled by merging cavity magnonics with topological insulators.
An electrogenetic interface to program mammalian gene expression by direct current
Authors: Huang Jinbo , Xue Shuai , Buchmann Peter , Teixeira Ana Palma , Fussenegger Martin 
Published: July 2023

AbstractWearable electronic devices are playing a rapidly expanding role in the acquisition of individuals’ health data for personalized medical interventions; however, wearables cannot yet directly program gene-based therapies because of the lack of a direct electrogenetic interface. Here we provide the missing link by developing an electrogenetic interface that we call direct current (DC)-actuated regulation technology (DART), which enables electrode-mediated, time- and voltage-dependent transgene expression in human cells using DC from batteries. DART utilizes a DC supply to generate non-toxic levels of reactive oxygen species that act via a biosensor to reversibly fine-tune synthetic promoters. In a proof-of-concept study in a type 1 diabetic male mouse model, a once-daily transdermal stimulation of subcutaneously implanted microencapsulated engineered human cells by energized acupuncture needles (4.5 V DC for 10 s) stimulated insulin release and restored normoglycemia. We believe this technology will enable wearable electronic devices to directly program metabolic interventions.
Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis
Authors: Tang Qiaoli , Shi Wanting , Liu Ming , Tang Liqin , Ren Wei , Shi Shaolin 
Published: July 2023

Abstract
MPV17 is a mitochondrial inner membrane protein, and its deficiency can cause mitochondrial DNA (mtDNA) depletion, increase reactive oxygen species (ROS), and promote apoptosis in several cell types, suggesting that MPV17 plays a protective role in cells although the underlying mechanism remains unknown. To test whether MPV17 is also protective in diabetic kidney disease, we treated Mpv17-deficient mice with streptozotocin (STZ) and surprisingly found that they were resistant to diabetes. Mpv17 deficiency was also found to confer resistance to the diabetes induced by an insulin mutation (Ins2Akita), which represents a mouse model of monogenic diabetes characterized by proinsulin misfolding and β-cell failure. In both STZ and Ins2Akita models, Mpv17 mutants had significantly less severe β-cell loss and apoptosis compared with the wild-type mice. We next showed that MPV17 is expressed in β-cells of mice normally, suggesting that MPV17 acts β-cells autonomously to facilitate apoptosis. Consistently, Mpv17 knockdown improved the viability and ameliorated the apoptosis of cultured MIN6 cells treated with STZ and palmitic acid (PA), respectively, accompanied by prevention of caspase 3 activation. The proapoptotic effect of MPV17 in β-cells is in contrast with its known anti-apoptotic effect in other cell types. Thus, we have identified a novel regulator of β-cell death in diabetes development.
Identifying Medications Underlying Communication Atypicalities in Psychotic and Affective Disorders: A Pharmacovigilance Study Within the FDA Adverse Event Reporting System
Authors: Fusaroli Michele , Simonsen Arndis , Borrie Stephanie A. , Low Daniel M. , Parola Alberto , Raschi Emanuel , Poluzzi Elisabetta , Fusaroli Riccardo 
Published: July 2023

Purpose:
Communication atypicalities are considered promising markers of a broad range of clinical conditions. However, little is known about the mechanisms and confounders underlying them. Medications might have a crucial, relatively unknown role both as potential confounders and offering an insight on the mechanisms at work. The integration of regulatory documents with disproportionality analyses provides a more comprehensive picture to account for in future investigations of communication-related markers. The aim of this study was to identify a list of drugs potentially associated with communicative atypicalities within psychotic and affective disorders.

Method:
We developed a query using the Medical Dictionary for Regulatory Activities to search for communicative atypicalities within the FDA Adverse Event Reporting System (updated June 2021). A Bonferroni-corrected disproportionality analysis (reporting odds ratio) was separately performed on spontaneous reports involving psychotic, affective, and non-neuropsychiatric disorders, to account for the confounding role of different underlying conditions. Drug–adverse event associations not already reported in the Side Effect Resource database of labeled adverse drug reactions (unexpected) were subjected to further robustness analyses to account for expected biases.

Results:
A list of 291 expected and 91 unexpected potential confounding medications was identified, including drugs that may irritate (inhalants) or desiccate (anticholinergics) the larynx, impair speech motor control (antipsychotics), or induce nodules (acitretin) or necrosis (vascular endothelial growth factor receptor inhibitors) on vocal cords; sedatives and stimulants; neurotoxic agents (anti-infectives); and agents acting on neurotransmitter pathways (dopamine agonists).

Conclusions:
We provide a list of medications to account for in future studies of communication-related markers in affective and psychotic disorders. The current test case illustrates rigorous procedures for digital phenotyping, and the methodological tools implemented for large-scale disproportionality analyses can be considered a road map for investigations of communication-related markers in other clinical populations.

Supplemental Material:

https://doi.org/10.23641/asha.23721345
Self-Stigma of Stuttering: Implications for Communicative Participation and Mental Health
Authors: Boyle Michael P. , Cheyne Madeline R. , Rosen Amy L. 
Published: July 2023

Purpose:
The purpose of this study was to determine if self-stigma–related variables predicted communicative participation and mental health in adults who stutter. A progressive model of self-stigma was theorized and tested.

Method:

Adults who stutter (
N
= 344) completed a survey that included measures of communicative participation, global mental health, and a variety of self-stigma–related variables including perceived enacted stigma, stigma awareness, anticipated stigma, felt stigma, stereotype agreement, and stigma application, in addition to demographic and speech-related variables. Hierarchical regression was performed to test whether self-stigma–related variables progressively explained significant variance in both communicative participation and global mental health.c

Results:
After controlling for demographic and speech-related variables, stigma-related variables were found to be significant predictors of both communicative participation and global mental health among adults who stutter. Most self-stigma–related variables entered later in the model predicted additional unique variance in the outcome variables than the self-stigma–related variables entered in previous steps, thus supporting the trickle-down and progressive nature of the self-stigma model theorized.

Conclusions:
Accounting for self-stigma in the assessment and treatment of individuals who stutter may identify and ultimately reduce environmental and personal barriers to communicative functioning and well-being in people who stutter. The self-stigma terminology and model described in this study will help practitioners, researchers, and the public better understand the process of self-stigma and how it may be associated with adverse outcomes experienced by people who stutter.
Counseling Confidence in Preservice and Early Career Speech-Language Pathologists
Authors: Johnson Leslie W. , Hall Kellyn D. 
Published: July 2023

Purpose:
Effective counseling skills are included in standards of practice by speech-language pathology accrediting and training programs, although many speech-language pathologists (SLPs) continue to report a lack of skills in this area. The purpose of this study was to determine whether SLP graduate students and early career SLPs who have taken a dedicated counseling course report higher levels of confidence in counseling skills than those whose counseling training was infused across the curriculum. A secondary aim was to determine which specific counseling skills have the strongest relationship with completing a counseling course.

Method:

A survey, adapted from the Counselor Activity Self-Efficacy Scales for Speech-Language Pathologists, was used to gather information from SLP graduate students and early career SLPs using nonprobability sampling. Data were analyzed from 140 surveys. Research questions were answered descriptively and with independent-samples
t
tests. Correlation analysis was used to determine which counseling skills were linked with completion of a dedicated counseling course.

Results:
Participants who completed a counseling course reported significantly increased confidence across all counseling domains assessed: Helping Skills Exploration, Helping Skills Action, Helping Skills Insight, Emotional Support Skills, and Session Management. Twenty-six counseling skills were significantly correlated to completing a counseling course. Regardless of educational approach, confidence in personal adjustment counseling skills was lower than that in informational counseling skills. However, personal adjustment counseling skills confidence was significantly higher for participants who had completed a dedicated course.

Conclusions:
Overall, the findings of this study suggest that dedicating a course to the education and training of counseling skills in graduate programs may be beneficial. Implications of these findings for clinical applications and future directions in training are discussed.
Retracted Article: A Post-Evaluation Method for Integrated Energy Systems Based on Triangular Whitening Weight Function
Authors: Wang Yongli , Teng Yue , Zhou Hanzhi , Dou Zhenlan , Zhang Chunyan , Sun Pei 
Published: July 2023

The authors have expressed the wish to retract this article on the ground that there are
some technical issues that require to be corrected.
1. The indicator does not provide a specific quantification method.
2. The indicator weight is obtained through subjective evaluation where there is a
significant deviation between the actual project verification and the current
comprehensive energy system operation results.
3. The post evaluation index values in the article are only obtained based on the average
value obtained from expert scoring, and the fitting results do not have reference
significance.
The Publisher and Editor(s) approved to the retraction.
Effect of Foreign Surface Pacification with Albumin, Aprotinin, Propofol, and High-density Lipoprotein
Authors: Fontaine Eustace , Warwick Richard , Sastry Priya , Poullis Michael 
Published: July 2023

Foreign surface pacification may significantly reduce the detrimental effects of the cardiopulmonary bypass (CPB) circuit. To date, albumin is the only intervention consistently shown to be beneficial. The cationic physical properties of aprotinin and the known negative charge on the plastic CPB circuit mean that aprotinin binds to the CPB circuit and membrane oxygenator. A previously validated model involving a parallel plate glass slide technique was used. The effects of albumin, aprotinin, propofol, and high-density lipoprotein (HDL) were assessed by the ability to inhibit platelet adhesion to the glass slide surface. The experiment was repeated with collagen-coated glass slides to reproduce the clinical effect of endothelial denudation. The interventions were repeated on membrane oxygenators that are used for CPB. Aprotinin resulted in a minimal reduction in platelet adhesion to uncoated or collagen-coated glass slides.
HDL significantly reduced platelet adhesiveness to uncoated or collagen-coated glass slides. Human albumin solution (HAS) and propofol produced an intermediary inhibitory effect on platelet adhesion on both collagen-coated and uncoated glass slides. The same effect was seen with membrane oxygenators that are used during CPB. HDL produced a significant reduction of neutrophil activation when used to coat a membrane oxygenator. Foreign surface pacification with HDL may have beneficial effects as assessed by platelet adhesiveness in a parallel plate assay. Aprotinin had minimal effect, and propofol had an intermediate effect. The same results were obtained using membrane oxygenators, confirming the validity of the parallel plate technique as clinically valid.
Drucksenkender Effekt der interventionellen Fistelokklusion bei Sekundärglaukom infolge orbital drainierender intrazerebraler Fisteln
Authors: Kesper Christiane , Skalej Martin , Huth Andrea , Viestenz Arne , Heichel Jens 
Published: July 2023

Zusammenfassung
Hintergrund Carotis-Sinus-cavernosus-Fisteln (CSCF) stellen pathologische Verbindungen der A. carotis interna und/oder externa (und/oder deren Äste) zum Sinus cavernosus dar. Vor
allem bei Drainage über die V. ophthalmica superior kommt es zu ophthalmologischen Symptomen und Problemen.
Material und Methoden In die retrospektive monozentrische Studie wurden 7 Augen von 6 Patienten eingeschlossen, bei denen ein hochgradiger Verdacht für eine CSCF bestand. Bei den
eingeschlossenen Patienten wurde eine digitale Subtraktionsangiografie (DSA) durchgeführt, bei der bei gesichertem Vorliegen einer CSCF ein interventioneller Fistelverschluss erfolgte. Vier
der 6 Patienten erhielten eine prä- und postinterventionelle Tagesaugendruckprofilmessung (TDP). Ausgewertet wurden Anamnese, Symptome, Visus, spaltlampenmikroskopischer Befund, TDP sowie
der DSA-Befund.
Ergebnisse Die häufigsten von den Patienten angegebenen Symptome waren ein gerötetes Auge, Diplopie und Exophthalmus. Bei der Augeninnendruckmessung zeigte sich bei 83,33% der
Patienten ein erhöhter Augeninnendruck (IOD). Der mittlere IOD betrug in der Tagesaugendruckprofilmessung am betroffenen Auge präinterventionell 23,5 (± 2,7) mmHg im Vergleich zu 14,1
(± 2,3) mmHg am gesunden Auge. Damit konnte im Seitenvergleich ein signifikanter Unterschied nachgewiesen werden (p = 0,0047). Bei der postinterventionellen Messung zeigte sich ein mittlerer
IOD von 15,3 (± 1,0) mmHg am betroffenen Auge und somit ein signifikanter Unterschied zu der präinterventionellen Messung am betroffenen Auge (p = 0,0018). Präinterventionell wandten 4 der 6
Patienten mit CSCF drucksenkende Augentropfen an, postinterventionell waren es noch 2 Patienten. Auch die Anzahl der verwendeten Antiglaukomatosa konnte gesenkt werden.
Schlussfolgerung Der interventionelle Fistelverschluss stellt eine effektive Methode zur Behandlung der sekundären Augeninnendrucksteigerung bei CSCF dar. Es zeigte sich bei
erfolgreichem Verschluss der Fistel eine signifikante Erniedrigung des Augeninnendruckes, die durch alleinige Gabe von Antiglaukomatosa nicht möglich war. Als Differenzialdiagnose sollte das
Radius-Maumenee-Syndrom in Betracht gezogen werden.