bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing the Neuroimmune Environment of Offspring in a Novel Model of Maternal Allergic Asthma and Particulate Matter Exposure
Authors: Tamayo Juan M. , Osman Hadley C. , Schwartzer Jared J. , Pinkerton Kent , Ashwood Paul 
Published: July 2023

Abstract
Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by the presence of decreased social interactions and an increase in stereotyped and repetitive behaviors. Epidemiology studies suggest that cases of ASD are on the rise. Similarly, rates of asthma are increasing, and the presence of maternal asthma during pregnancy increases the likelihood of a child being later diagnosed with ASD. Particulate matter (PM), via air pollution, is an environmental factor known to worsen the symptoms of asthma, but also, PM has been associated with increased risk of neuropsychiatric disorders including ASD. Despite the links between asthma and PM with neuropsychiatric disorders, there is a lack of laboratory models investigating combined prenatal exposure to asthma and PM on offspring neurodevelopment. Thus, we developed a novel mouse model that combines exposure to maternal allergic asthma (MAA) and ultrafine iron-soot (UIS), a common component of PM. In the current study, female BALB/c mice were primed for allergic asthma with ovalbumin (OVA) prior to pregnancy. Following mating and beginning on gestational day 2 (GD2), dams were exposed to either aerosolized OVA or phosphate buffered saline (PBS) for 1 hour. Following the 1-hour exposure, pregnant females were then exposed to UIS or clean air for 4 hours. Offspring brains were collected at postnatal days (P)15 and (P)35. Cortices and hippocampal regions were then isolated and assessed for changes in cytokines using a Luminex bead-based multiplex assay. Analyses identified changes in many cytokines across treatment groups at both timepoints in the cortex, including interleukin-1 beta (IL-1β), IL-2, IL-13, and IL-17, which remained elevated from P15 to P35 in all treatment conditions compared to controls. In the hippocampus at P15, elevations in cytokines were also identified across the treatment groups, namely interferon gamma (IFNγ) and IL-7. The combination of MAA and UIS exposure (MAA-UIS) during pregnancy resulted in an increase in microglia density in the hippocampus of offspring, as identified by IBA-1 staining. Together, these data indicate that exposure to MAA, UIS, and MAA-UIS result in changes in the neuroimmune environment of offspring that persist into adulthood.
Adhesion G protein-coupled receptor G2 accelerates the proliferation of cancer cells by promoting the formation of CDK4/CCND1
Authors: Li Nian-nian , Li Si-ying , Gong Ningning , Liu Wenbo , Gao Jian , Hao Furong , Hong Ninglin , Wang Zuxuan , He Sha , Zhang Yunlong , Wei Jie , Liu Chunxiao , Meng Gang , Zhu Hongguang , Wu Yuyun , Liu Bin 
Published: July 2023

Abstract
Gastric cancer is a common malignant tumor in humans. Analysis of clinical data of gastric cancer revealed that adhesion G protein-coupled receptor G2 (ADGRG2), endoplasmic reticulum oxidoreductase 1β, lactate dehydrogenase B and chromosome 1 open reading frame 115 were abnormally highly expressed in gastric cancer. ADGRG2 was not only highly expressed in gastric cancer tissues, but was also associated with poor prognosis in patients with gastric cancer. Numerous oncogenes and tumor suppressor genes are directly involved in the regulation of the cell cycle. ADGRG2 was shown to promote cell proliferation by promoting the G1/S transition. ADGRG2 did not affect the expression of CDK4 or cyclin D1 (CCND1), but was found to affect the cell cycle by promoting the formation of the cell cycle-dependent complex CDK4/CCND1, thereby promoting cell proliferation, and affecting the formation and development of gastric cancer.
Factors Affecting Female Student Dropout Rates in Hargeisa, Somaliland High Schools
Authors: Duale Hassan Abdillahi , Aden Mumtas Yousuf , Mohamed Jama Osman , Ismail Abdihakim Ahmed 
Published: July 2023

Abstract
Every society's economic development has been based on education. Female student abandonment, on the other hand, constitute a considerable drain and loss on a country's education budget, especially as high school possibilities are predicted to grow. This study investigated various variables that influence the dropout rate of girls from high school in Hargeisa, Somaliland. The study was directed by the following precise goals such as to examine the effects of domestic labor, to assess the influence of parents’ attitudes and to determine the influence community’s perception on girl child education in Hargeisa. The study was carried out using a descriptive research approach. The demographic being targeted included Principles, female students, educators, and parents. Purposive sampling was used to choose respondents from the designated high schools. The sample size was 68 respondents. Questionnaires were chosen as collecting data instruments. Descriptive methods of statistical analysis such as percent and frequencies were used to analyze quantitative data. The data was presented using tables and charts. According to The study results, domestic labor, parent’s attitudes, and community perceptions are resulting in a higher percentage of female high school dropouts. According to findings, 50% the respondents identified working as house helps as a reason for girls dropping out of school. Additionally, 79% of the respondents believed that parents have a responsibility in their daughter's education and dropout, while 63% of the respondents stated that their communities do not prioritize or encourage girls' education. The study suggested that it is essential for girls to have access to basic education as it is their fundamental right as stated in the Somaliland constitution. Additionally, the study recommended conducting further research in secondary schools to identify other challenges that girls face and find effective strategies to help them stay in school and continue their education.
Case Report: Emerging losses of managed honey bee colonies
Authors: Evans Jay D , Chen Yanping , Lamas Zachary S 
Published: July 2023

Abstract
United States commercial beekeepers prepare honey bee colonies for almond pollination in California each year in late January to early February. This represents the largest managed pollination event in the world and involves more than half of all U.S. honey bee colonies. In winter 2023, numerous colonies in Florida which were graded as suitable for almonds (larger than ten frames of bees) dwindled suddenly or altogether died within several weeks, just prior to movement for almonds. The timing of these losses and morbidity caused severe economic harm to affected operations. This study reports interviews with affected stakeholders, their economic harm, and analyses of pathogens and parasites found in their colonies.
Reversal of epigenetic age and improvement of body composition in consumers of wine enriched with Resveratrol.
Authors: Pastor Raúl Francisco , Iermoli Roberto Héctor , Saporito-Magriña Christian Martín , Pastor Isabel , Pastor Elena , Carabetti Zulma Manfredi , Iermoli Laura Valeria , Lairion Fabiana , Chiesa Iris , Sarrasague Margarita Martínez , Cimato Alejandra , Rodriguez Aldana , Taborda Claudia , Carbia Claudio , Bavasso Carlos Amadeo , Auzmendi Jerónimo , Lazarowski Alberto , Repetto Marisa Gabriela 
Published: July 2023

Abstract

Biological aging (BA) is a universal process that involves the deterioration of vital functions. One of the root causes of BA is epigenetic DNA hypermethylation. The latter defines epigenetic age (EA), being the most important risk factor for chronic non-communicable diseases, so its modulation is an exciting emerging field of science. Although there are numerous investigations on the mechanisms of aging, today there are few studies that measure EA in humans after an intervention. The objective of this research was to evaluate the EA and the body composition after the consumption of wine enriched with Resveratrol. The results showed a decrease in EA after three and a half months of the study intervention (p < 0.01). We also demonstrated significant improvements in body composition with a 1.6 kg decrease in fat mass, (p < 0.0004); and an increase in muscle mass of 300 g (p < 0.019). To our knowledge, it is the first time that a highly significant reduction of EA has been demonstrated in consumers of wine enriched with Resveratrol combined with a healthy remodeling of body composition. These findings could be relevant to maintaining health, increasing life expectancy, and preventing the damages caused by aging.
A folyamatszemlélet erősítése az értékteremtésben
Authors: Balázs-Kalász Adrienn 
Published: July 2023

[Demeter Krisztina – Gelei Andrea – Matyusz Zsolt – Nagy Judit (2022): Tevékenységmenedzsment. Akadémiai Kiadó, ISBN 978 963 454 759 4]
Application of black-box models based on artificial intelligence for the prediction of chlorine and TTHMs in the trunk network of Bogotá, Colombia
Authors: Enriquez Laura , González Laura , Saldarriaga Juan G. 
Published: July 2023

Abstract

The chlorine and total trihalomethane (TTHM) concentrations are sparsely measured in the trunk network of Bogotá, Colombia, which leads to a high uncertainty level at an operational level. For this reason, this research assessed the prediction accuracy for chlorine and TTHM concentrations of two black-box models based on the following artificial intelligence techniques: artificial neural networks (ANNs) and adaptive neuro-fuzzy inference system (ANFIS) as a modelling alternative. The simulation results of a hydraulic and water quality analysis of the network in EPANET and its multi-species extension EPANET-MSX were used for training the black-box models. Subsequently, the Threat Ensemble Vulnerability Assessment-Sensor Placement Optimization Tool (TEVA-SPOT) and Evolutionary Polynomial Regression-Multi-Objective Genetic Algorithm (EPR-MOGA-XL) were jointly applied to select the most representative input variables and locations for predicting water quality at other points of the network. ANNs and ANFIS were optimized with a multi-objective approach to reach a compromise between training performance and generalization capacity. The ANFIS models had a higher mean Training and Test Nash–Sutcliffe Index (NSI) in contrast with ANNs. In general, the models had a satisfactory mean prediction performance. However, some of them did not achieve suitable Test NSI values, and the prediction accuracy for different operational statuses was limited.
Novel Vesicular Bilosomal Delivery Systems for Dermal/Transdermal
Applications
Authors: Suvarna Vasanti , Mallya Rashmi , Deshmukh Kajal , Sawant Bhakti , Khan Tabassum Asif , Omri Abdelwahab 
Published: July 2023

Abstract:
The application of therapeutically active molecules through the dermal/transdermal route into
the skin has evolved as an attractive formulation strategy in comparison to oral delivery systems for the
treatment of various disease conditions. However, the delivery of drugs across the skin is limited due to
poor permeability. Dermal/transdermal delivery is associated with ease of accessibility, enhanced safety,
better patient compliance, and reduced variability in plasma drug concentrations. It has the ability to
bypass the first-pass metabolism, which ultimately results in steady and sustained drug levels in the
systemic circulation. Vesicular drug delivery systems, including bilosomes, have gained significant
interest due to their colloidal nature, improved drug solubility, absorption, and bioavailability with prolonged
circulation time for a large number of new drug molecules. Bilosomes are novel lipid vesicular
nanocarriers comprising bile salts, such as deoxycholic acid, sodium cholate, deoxycholate, taurocholate,
glycocholate or sorbitan tristearate. These bilosomes are associated with high flexibility, deformability, and
elasticity attributed to their bile acid component. These carriers are advantageous in terms of improved skin
permeation, increased dermal and epidermal drug concentration, and enhanced local action with reduced
systemic absorption of the drug, resulting in reduced side effects. The present article provides a comprehensive
overview of the biopharmaceutical aspects of dermal/transdermal bilosome delivery systems, their
composition, formulation techniques, characterization methods, and applications.
The power of mass media in literature development in Indonesia
Authors: Pramono Dedi , Fadillah Dani 
Published: July 2023

This study aims to reveal how the mass media has a very large role to develop literature in Indonesia. This is important to mention considering that literature is one of the signs of a nation's civilization, therefore support from various directions for developing literature is very meaningful. With this research, it is hoped that the world of Indonesian literature can further develop in the future, especially through the role of the mass media. This research was conducted using a qualitative approach, the data was collected through interviews and a comprehensive review of documents. The data obtained is then reduced and compiled into a scientifically justifiable research report. The results of this study show that the contribution of the mass media is very large in the development of literature in Indonesia. Literature in Indonesia has an important role in the national identity as an international exchange. Literature can be called the nation, language, and literature which has become the glue between a country
Longitud de sarcómeros en músculos de bovinos criollos Romosinuano cruzados con Brahman, en Córdoba, Colombia
Authors: Perdomo-Ayola Sandra Carolina , Pulido-Pupo Jose Jaime , Sierra-Monrroy Janeth Alexandra , Aguayo-Ulloa Lorena 
Published: July 2023

Objetivo. Determinar histológicamente la longitud de los sarcómeros (LS) en muestras de cortes comerciales de bovinos F1 Romosinuano por Cebú. Materiales y métodos. Dieciocho cortes musculares con cuatro repeticiones de diez animales fueron analizados para la medición de la LS, teñidos con hematoxilina – Eosina y posteriormente se contaron el número de bandas A presentes en una distancia de 20 µm en cada uno de los cortes. Resultados. La longitud promedio de los sarcómeros fue de 2.12 µm. Los sarcómeros más largos se observaron en los músculos iliopsoas y tensor de la fasciae latae con 3.32 y 3.26 µm, respectivamente, catalogándose el primero en el mercado como corte fino, debido a su terneza. En cuanto a los LS cortos, se pudo apreciar en los músculos gluteobiceps biceps femoris (1.69 µm) y gluteus medius (1.71 µm). Las diferencias en la longitud del sarcómero (p<0.05) se asociaron con el tipo de musculo. Conclusión. La LS es un indicador importante para comprender la transformación del músculo en carne durante los diferentes manejos proporcionado al animal y a la canal. Son necesarios más estudios que consideren diferenciar por factores como raza, conservación en frio y disposición de las canales sobre la LS, y en qué medida afectan las cualidades del producto final.
Phone-Based Text Therapy for Youth Mental Health: Rapid Review
Authors: Karnik Varun , Henderson Hamish , Khan Urooj Raza , Boyd James 
Published: July 2023

Background
Mental illness has become a prevalent issue impacting adolescents worldwide. Many barriers, including stigma and poor health literacy, prevent this population group from accessing reliable mental health care services. Synchronous text–therapy counseling is an underused therapeutic approach in combating adolescent mental illness. Phone-based text therapy is uniquely placed to offer personalized counseling to adolescents through a familiar and engaging treatment modality.

Objective
This rapid review aims to understand the clinical effectiveness, usability, and accessibility of phone-based text therapy for youth mental health.

Methods
Cochrane CENTRAL, Embase, PubMed, and PsycINFO were used to search for suitable literature. Five groups of keywords were used: those related to (1) “therapy,” (2) “text,” (3) “phone,” (4) “youth,” and (5) “mental health.” Eligibility criteria were formed through the PICO (Population, Intervention, Control, and Outcome) framework. Studies were included if a synchronous phone-based text therapy intervention was used in an adolescent population, with an age range of 12-24 years. Only literature available in full-text, English, and a peer-reviewed journal was considered. Furthermore, a date limit of 5 years was set to reflect the recent development of digital interventions for mental health. Pertinent information from each study was tabulated, and a narrative synthesis was used to assess, describe, and organize the included studies comprehensively and concisely.

Results
Of the 771 studies dual screened, 7 studies were included in this rapid review. Most of the exclusions occurred due to the use of the wrong intervention, such as asynchronous messaging. The selected studies had a low risk of bias and were suitable for the review. All interventional trials demonstrated reductions in mental health symptoms, primarily depression and anxiety. Most studies displayed high usability among participants, while data were unclear regarding accessibility.

Conclusions
This review reveals the high potential of phone-based text therapy as an intervention for adolescents experiencing mental illness. We hope that this review promotes further refinement of text-based phone therapies and encourages future research on this subject matter.
ChatGPT vs Google for Queries Related to Dementia and Other Cognitive Decline: Comparison of Results
Authors: Hristidis Vagelis , Ruggiano Nicole , Brown Ellen L , Ganta Sai Rithesh Reddy , Stewart Selena 
Published: July 2023

Background
People living with dementia or other cognitive decline and their caregivers (PLWD) increasingly rely on the web to find information about their condition and available resources and services. The recent advancements in large language models (LLMs), such as ChatGPT, provide a new alternative to the more traditional web search engines, such as Google.

Objective
This study compared the quality of the results of ChatGPT and Google for a collection of PLWD-related queries.

Methods
A set of 30 informational and 30 service delivery (transactional) PLWD-related queries were selected and submitted to both Google and ChatGPT. Three domain experts assessed the results for their currency of information, reliability of the source, objectivity, relevance to the query, and similarity of their response. The readability of the results was also analyzed. Interrater reliability coefficients were calculated for all outcomes.

Results
Google had superior currency and higher reliability. ChatGPT results were evaluated as more objective. ChatGPT had a significantly higher response relevance, while Google often drew upon sources that were referral services for dementia care or service providers themselves. The readability was low for both platforms, especially for ChatGPT (mean grade level 12.17, SD 1.94) compared to Google (mean grade level 9.86, SD 3.47). The similarity between the content of ChatGPT and Google responses was rated as high for 13 (21.7%) responses, medium for 16 (26.7%) responses, and low for 31 (51.6%) responses.

Conclusions
Both Google and ChatGPT have strengths and weaknesses. ChatGPT rarely includes the source of a result. Google more often provides a date for and a known reliable source of the response compared to ChatGPT, whereas ChatGPT supplies more relevant responses to queries. The results of ChatGPT may be out of date and often do not specify a validity time stamp. Google sometimes returns results based on commercial entities. The readability scores for both indicate that responses are often not appropriate for persons with low health literacy skills. In the future, the addition of both the source and the date of health-related information and availability in other languages may increase the value of these platforms for both nonmedical and medical professionals.
Untitled Item Rapid reduction of HbA1c and early worsening of diabetic retinopathy: A real-world population-based study in subjects with type 2 diabetes
Authors: Simó Rafael , Franch-Nadal Josep , Vlacho Bogdan , Real Jordi , Amado Ester , Flores Juana , Mata-Cases Manel , Ortega Emilio , Rigla Mercedes , Vallés Joan-Anton , Hernández Cristina 
Published: July 2023

<p> </p>
<p><strong>ABSTRACT</strong></p>
<p><strong>Objective:</strong> Early worsening of diabetic retinopathy (EWDR) due to the rapid decrease of blood glucose levels is a concern in diabetes treatment. The aim of the present study was to evaluate whether this is an important issue in subjects with type 2 diabetes with mild or moderate non-proliferative DR (NPDR), which represent the vast majority of subjects with DR attended in the Primary Care. </p>
<p><strong>Research Design and Methods:</strong> retrospective nested case-control study of subjects with type 2 diabetes and previous mild or moderate NPDR. Using SIDIAP <em>(“Sistema d'informació pel Desenvolupament de la Recerca a Atenció Primària”)</em> database, we selected 1,150 individuals with EWDR and 1,150 matched controls (DR without EWDR). The main variable analyzed was the magnitude of the reduction of HbA1c in previous 12 months. The reduction of HbA1c was categorized in rapid (>1.5% reduction in < 12 months) and very rapid (>2% in <6 months). </p>
<p><strong>Results:</strong> We did not find any significant difference in HbA1c reduction between cases and controls (0.13±1.21 vs. 0.21±1.18; p=0.12). HbA1c reduction did not show significant association with worsening of DR, neither in the unadjusted analyses nor in adjusted statistical models that included the main confounding variables: duration of diabetes, baseline HbA1c, presence of hypertension and antidiabetic drugs. In addition, when stratification by baseline HbA1c was performed we did not find that those patients with higher levels of HbA1c presented higher risk to EWDR.</p>
<p><strong>Conclusion:</strong> Our results suggest that the rapid reduction of HbA1c is not associated with progression of mild or moderate NPDR. </p>
Quality Characteristics of Sourdough Bread with The Addition of Water Yest and Wheat-Mocaf Flours Combination
Authors: Azni Intan Nurul , Prabawati Alberta Teresa Anggi , Basriman Iman , Amelia Julfi Restu 
Published: July 2023

Sourdough bread embraces health benefits due to the fermentation process carried out in the manufacturing process. The quality of sourdough bread is influenced by the specific microbes (yeast) that develop in the sourdough and the type of flour. The purpose of this study was to determine whether the type of fruit water yeast and the combination of wheat flour and mocaf could affect the quality of sourdough bread. The research design used was a factorial, completely randomized design with two factors and three replications. Water yeast from apple and salaca fruits as the first factors, and the second factor is a combination of wheat flour and mocaf as much as (100:0), (80:20), and (60:40). Physico-chemical and organoleptic characteristics were observed in the study. ANOVA and DMRT further tests were used for data analysis. Research shows the type of fruit water yeast can affect the moisture and carbohydrate content of sourdough bread. The combination of wheat flour and mocaf has a significant effect on the physical (hardness), chemical (content of water, ash, fat, protein, and carbohydrates), and organoleptic qualities (colour and the hedonic quality of texture) The combination of wheat flour and mocaf as much as 60:40 is a combination that produces sourdough bread of the highest quality. Keywords: Apple, Mocaf, Sourdough, Wheat flour, Zalacca