bluuebunny/crossref_metadata_2025_split huggingface dataset:
Piloting a multidisciplinary approach to improve outcomes of fetal whole exome sequencing: An overview of workflow and case example
Authors: Micke Kestutis C. , Elfman Hannah M. , Fantauzzo Katherine A. , McGrath Patrick S. , Clouthier David E. , McCandless Shawn E. , Larson Austin , Putra Manesha , Cuneo Bettina F. , Reynolds Regina M. , Zaretsky Michael V. 
Published: February 2023

AbstractIntroductionWhole exome sequencing (WES) has increasingly become integrated into prenatal care and genetic testing pathways. Current studies of prenatal WES have focused on diagnostic yield. The possibility of obtaining a variant of uncertain significance and lack of provider expertise are frequently described as common barriers to clinical integration of prenatal WES. We describe the implementation and workflow for a multidisciplinary approach to effectively integrate prenatal WES into maternal‐fetal care to overcome these barriers.MethodsA multidisciplinary team reviews and approves potential cases for WES. This team reviews WES results, reclassifying variants as appropriate and provides recommendations for postnatal care. A detailed description of this workflow is provided, and a case example is included to demonstrate effectiveness of this approach.Our team has approved 62 cases for WES with 45 patients ultimately pursuing WES. We have achieved a diagnostic yield of 40% and the multidisciplinary team has played a role in variant interpretation in 50% of the reported variants of uncertain significance.ConclusionsThis approach facilitates communication between prenatal and postnatal care teams and provides accurate interpretation and recommendations for identified fetal variants. This model can be replicated to ensure appropriate patient care and effective integration of novel genomic technologies into prenatal settings.
Dopamine agonists and risk of lung cancer in patients with restless legs syndrome
Authors: Hernandez‐Con Pilar , Shults Justine , Willis Allison W. , Yang Yu‐Xiao 
Published: February 2023

AbstractPurposeTo examine the association between long‐term use of dopamine agonists (DAs) and the risk of lung cancer in patients with restless legs syndrome (RLS).MethodsWe conducted a retrospective cohort study using Optum Clinformatics® database. We included adults ≥40 years diagnosed with RLS during the study period (1/2006–12/2016). Follow‐up started with the first RLS diagnosis and ended on the earliest of: incident diagnosis of lung cancer, end of enrollment in the database or end of the study period. The exposure of interest was cumulative duration of DAs use, measured in a time‐varying manner. We constructed a multivariable Cox regression model to estimate HRs and 95% CIs for the association between lung cancer and cumulative durations of DA use, adjusting for potential confounding variables.ResultsWe identified 295 042 patients with a diagnosis of RLS. The mean age of the cohort was 62.9; 66.6% were women and 82.3% were white. The prevalence of any DA exposure was 40.3%. Compared to the reference group (no use and ≤1 year), the crude HRs for lung cancer were 1.16 (95% CI 0.99–1.36) and 1.14 (95% CI 0.86–1.51) for 1–3 years and >3 years of cumulative DA use, respectively. The adjusted HR for lung cancer was 1.05 (95% CI 0.88–1.25) for 1–3 years and 1.02 (95% CI 0.76–1.37) for >3 years of cumulative DA use, respectively.ConclusionsAt typical doses for the clinical management of RLS, long‐term DA use was not associated with risk of lung cancer.
Ar‐H2O‐NH3 plasma grafting and polymerization of dopamine onto polytetrafluoroethylene to promote heparin immobilization
Authors: Sui Siyuan , Sun Hongmei , Ni Guohua , Liu Yafeng , Zheng Huan , Sun Tao , Kong Ling , Ma Zhongyang , Yuan Fangli 
Published: February 2023

AbstractThe surface of polytetrafluoroethylene (PTFE) is activated by argon (Ar), Ar mixed with water vapor (Ar‐H2O), and a mixture of Ar, water vapor, and ammonia (Ar‐H2O‐NH3) plasmas and then grafted onto polymerized dopamine/ethylene imine and immobilized heparin. Oxygen‐containing functional groups are all introduced onto the PTFE surface treated by three types of plasma. The amount of oxygen grafted is the highest in samples treated with Ar‐H2O‐NH3 plasma compared to that treated with Ar‐H2O plasma. An increase in the content of oxygen grafted onto PTFE contributes to an increase in the thickness and cross‐linking bond of the polymeric interlayer and then raises the density of the heparin coating. The thickness of the polydopamine/polyethylenimide intermediate layer on the surface of PTFE treated with Ar‐H2O‐NH3 plasma is 4.8 ± 0.3 μm, and the density of the immobilized heparin coating was 95 μg/cm2.
Population pharmacokinetic dosimetry model using imaging data to assess variability in pharmacokinetics of 177Lu‐PSMA‐617 in prostate cancer patients
Authors: Siebinga Hinke , Privé Bastiaan M. , Peters Steffie M. B. , Nagarajah James , Dorlo Thomas P. C. , Huitema Alwin D. R. , de Wit‐van der Veen Berlinda J. , Hendrikx Jeroen J. M. A. 
Published: February 2023

AbstractStudies to evaluate and optimize [177Lu]Lu‐PSMA treatment focus primarily on individual patient data. A population pharmacokinetic (PK) dosimetry model was developed to explore the potential of using imaging data as input for population PK models and to characterize variability in organ and tumor uptake of [177Lu]Lu‐PSMA‐617 in patients with low volume metastatic prostate cancer. Simulations were performed to identify the effect of dose adjustments on absorbed doses in salivary glands and tumors. A six‐compartment population PK model was developed, consisting of blood, salivary gland, kidneys, liver, tumor, and a lumped compartment representing other tissue (compartment 1–6, respectively), based on data from 10 patients who received [177Lu]Lu‐PSMA‐617 (2 cycles, ~ 3 and ~ 6 GBq). Data consisted of radioactivity levels (decay corrected) in blood and tissues (9 blood samples and 5 single photon emission computed tomography/computed tomography scans). Observations in all compartments were adequately captured by individual model predictions. Uptake into salivary glands was saturable with an estimated maximum binding capacity (Bmax) of 40.4 MBq (relative standard error 12.3%) with interindividual variability (IIV) of 59.3% (percent coefficient of variation [CV%]). IIV on other PK parameters was relatively minor. Tumor volume was included as a structural effect on the tumor uptake rate constant (k15), where a two‐fold increase in tumor volume resulted in a 1.63‐fold increase in k15. In addition, interoccasion variability on k15 improved the model fit (43.5% [CV%]). Simulations showed a reduced absorbed dose per unit administered activity for salivary glands after increasing radioactivity dosing from 3 to 6 GBq (0.685 Gy/GBq vs. 0.421 Gy/GBq, respectively). All in all, population PK modeling could help to improve future radioligand therapy research.
Lithological controls influence river form in contrasting sub‐catchments: The Scamander and Avenue Rivers, Tasmania
Authors: Fearman Lieselotte P. , Ellison Joanna C. 
Published: February 2023

AbstractBedrock influence on river channel form is difficult to assess, with many catchments dominated by glacial erosion and with blanketing sediments from both pluvial and fluvial sources. The Scamander catchment in Tasmania lacks glacial history and features two bedrock‐confined sub‐catchments of similar area and maximum flow length, but one dominated by Mathinna Group sedimentary rocks, and the other with large areas in granite lithology. Lithology types, stream network parameters and near stream slope angles were analysed using geographical information systems, and results of stream cross sections, channel form and planforms were compared for each lithology. Results showed that granite features low gradient, shallow streams with channel slope cross sections of <10°. Granite channels are irregular and dominated by large boulders that create channel roughness and resist incision. Weathering products of coarse quartz sand provide anchorages for in‐channel vegetation. By contrast, sedimentary Mathinna Group rocks feature steeply incised trough‐like channels, with near‐channel hillslope gradients mostly between 30° and 50°. Rectangular blocks disintegrate to gravel cobbles on the channel bed, providing poor anchorage for vegetation. Mathinna lithology influences steep, low roughness channels, and stable, incised recurved meanders formed by river interaction with vertical layers of resistant rock. The resistant bedrock lithology is demonstrated in this study to influence varied river planforms, near‐channel slope gradients, channel sediments and cross sections.
Association of Socio-Demographic Factors and Personal Hygiene with Infectious Childhood Dermatoses
Authors: Pathak Raksha , Shrestha Sameer , Poudel Prakash , Marahatta Suchana , Khadka Dhan Keshar 
Published: February 2023

Abstract

Background
Paediatric dermatoses vary vastly from adult dermatoses in terms of clinical presentation, management, and prognosis thereby generating special interest in this field. Many factors like geographical area, climatic exposure, seasons, culture, socioeconomic factors, hygiene, dietary habits, literacy influences pattern of skin diseases in children resulting in marked variation in prevalence and pattern.

Objectives
This study aims to find out association of socio-demographic factors and personal hygiene with infectious childhood dermatoses.

Materials and Methods
This was a hospital based cross-sectional study. All children (0–14 years) attending Dermatology outpatient clinics were enroled. Proforma was prepared to assess the socio-demographic factors and personal hygiene in the local context. Chi-square test was applied to find the association of the baseline variables with infectious dermatoses.

Results
A total of 364 children were enroled with mean age of 6.97 ± 4.23 years. Females (52.5%) were slightly more than males (47.5%). There were 201 (55.2%) infectious and 163 (44.8%) non-infectious dermatoses. Bacterial infections were the most common group (18.7%), followed by dermatitis and eczemas (14.0%) and viral infections (13.7%). Lower educational status of mother (p = 0.025), lower monthly family income (p = 0.008), lower socioeconomic status (p = 0.015) and less frequent bathing habits (p = 0.014) were associated with increased risk of infective dermatoses.

Conclusion
Infections and infestations were the most common paediatric dermatoses in our Outpatient Department. Female education, upliftment of socioeconomic status of family and improving personal hygiene may reduce the risk of skin infections in children.
Allometry in Late Devonian Podocopa ostracods (Crustacea) and its implications for ostracod ontogeny
Authors: Song Junjun , Huang Bing , Qie Wenkun 
Published: February 2023

AbstractPodocopa ostracods have abounded in various marine and non‐marine habitats since the early Palaeozoic and left a diverse fossil record in strata worldwide. This is particularly useful for stratigraphic correlation and palaeoenvironmental and palaeogeographical reconstructions. However, despite being the most numerous ostracods during the Palaeozoic, their origins, evolution, ontogeny and phylogeny remain poorly defined. This paper represents the first study of morphological variation in Devonian Platycopida ostracods (an order of Podocopa) using a geometric morphometric approach. Our results identify substantial shape variation in Cribroconcha honggulelengensis Song & Crasquin from the Upper Devonian Hongguleleng Formation of western Junggar, northwest China, demonstrating a remarkable change in juveniles between stages A‐3 and A‐2. Using linear regressions between principal component scores from right lateral view and carapace length, we demonstrate allometric growth patterns for this species. The body plan of C. honggulelengensis developed along an ontological variable: from an ovate outline with rare pores to an oblong outline with dense and large pores. Environmental factors should play an important role in shape determination during ontogeny of C. honggulelengensis.
Experimental studies on tensile behavior of reinforced engineered cementitious composite members with double steel rebars
Authors: Xu Hai‐Yang , Wang Dan‐Dan , Wang Ruo‐Yun , Kang Shao‐Bo , Liu Kun 
Published: February 2023

AbstractThis paper investigates the tensile behavior of reinforced engineering cementitious composite (ECC) members. Twelve reinforced ECC members were tested in uniaxial tension. The stress‐average strain curves, failure modes, and the strain of longitudinal reinforcement at selected sections were obtained during testing. The influence of reinforcement ratio on the load resistance and deformation capacity of members was determined. Test results showed that the tensile behavior of reinforced ECC members could be divided into three stages, namely, the elastic stage, the microcracking stage and the major cracking stage. ECC significantly contributed to the load resistance of reinforced ECC members before the formation of major cracks through tension stiffening effect. The load capacity and deformation capacity of reinforced ECC members increased with the increase of reinforcement ratios. For members with ungrooved steel bars, the ultimate load and ultimate strain increased by 130.0% and 115.2% with the reinforcement ratio increased from 1.01% to 2.26%. For members with grooved steel bars, the ultimate load and ultimate strain increased by 123.6% and 98.7% with the reinforcement ratio increased from 0.78% to 2.04%. Based on the test results, the failure mechanism of reinforced ECC members was analyzed and equations for predicting the load capacity of members were proposed. Comparisons between experimental and calculated load capacities suggested that the calculated results were in good agreement with the experimental values. The study on the tensile behavior of reinforced ECC members provides useful results for the design and application of reinforced ECC members.
System reconfiguration ontology to support model‐based systems engineering: Approach linking design and operations
Authors: Qasim Lara , Hein Andreas Makoto , Olaru Sorin , Garnier Jean‐Luc , Jankovic Marija 
Published: February 2023

AbstractSystem reconfiguration is essential in complex systems management, as it is an enabler of system flexibility and adaptability. It ensures system operation and increases reliability, availability, maintainability, testability, safety, and reuse of system entities and technologies. For the reconfiguration of a system in use, it is necessary to assess, in continuity, the system's state with regard to its context. Identifying data supporting system reconfiguration represents a major industrial challenge and is linked directly to the development of industrial reconfiguration tools. Reconfiguration tools are based on a data model, also called ontology, which represents key concepts of system reconfiguration and their relationships. A particular difficulty of developing the data model is the multi‐domain nature of reconfiguration. Furthermore, it needs to address a considerable diversity of system types. Few publications propose an ontology supporting data identification and tool development for the entire process. Hence, in this paper we propose to formalize the system reconfiguration process and propose an overarching ontology, which we call OSysRec. This ontology considers data at the management, dynamics, and structure level. The proposed ontology has been developed based upon expert knowledge and several industrial uses cases. The OSysRec ontology allowed a better understanding of the reconfiguration process, and hence it can be deployed for developing efficient and effective reconfiguration tools at the industrial scale. The ontology has been tested on an industrial case study to validate the proposed approach.
Beam functions for N-jettiness at N3LO in perturbative QCD
Authors: Baranowski Daniel , Behring Arnd , Melnikov Kirill , Tancredi Lorenzo , Wever Christopher 
Published: February 2023

Abstract
We present a calculation of all matching coefficients for N-jettiness beam functions at next-to-next-to-next-to-leading order (N3LO) in perturbative quantum chromodynamics (QCD). Our computation is performed starting from the respective collinear splitting kernels, which we integrate using the axial gauge. We use reverse unitarity to map the relevant phase-space integrals to loop integrals, which allows us to employ multi-loop techniques including integration-by-parts identities and differential equations. We find a canonical basis and use an algorithm to establish non-trivial partial fraction relations among the resulting master integrals, which allows us to reduce their number substantially. By use of regularity conditions, we express all necessary boundary constants in terms of an independent set, which we compute by direct integration of the corresponding integrals in the soft limit. In this way, we provide an entirely independent calculation of the matching coefficients which were previously computed in ref. [1].
Superstrata on orbifolded backgrounds
Authors: Shigemori Masaki 
Published: February 2023

Abstract
Some microstates of the Strominger-Vafa black hole are represented by smooth horizonless geometries called superstrata. The standard superstrata are deformations of AdS3 × S3, but there are also generalizations of superstrata on the orbifold (AdS3 × S3)/ℤp. In this paper, we discuss aspects of such orbifolded superstrata. We present a CFT perspective on the structure of orbifolded superstrata, showing that they can be constructed in a p-covering space of the orbifold CFT just as the standard superstrata. We also explicitly write down and study the geometry of the orbifolded superstrata, focusing on the difference from the non-orbifold case, p = 1. We discuss further generalization of superstrata to the ones on a fractional spectral flow of (AdS3 × S3)/ℤp. This generalization involves new fractional mode excitations of the CFT side. We estimate the number of those generalized superstrata, and show that their entropy is too small to account for the Strominger-Vafa entropy. We will discuss some implications of this result, related to the typical microstates of the black hole and the relevant supersymmetry index.
Influence of Ocean Tidal Loading on Continuous Gravity Observations in Eastern China
Authors: Zhao Yabo , Wei Jin , Hu Minzhang , Jiang Ying , Zhang Xiaotong , Liu Ziwei 
Published: February 2023

AbstractGlobal and regional ocean tide models are used to analyze the gravity effect of ocean tidal loading (OTL) for gravity stations in East China. The accuracies of OTL correction results for 21 gravity stations in East China are evaluated. The global ocean tide model is the most effective for the OTL correction of inland gravity stations (up to 90%) but is less effective for coastal gravity stations (only 60%). Considering regional ocean tide models, the applicability of OTL correction increased to 80% in coastal gravity stations. Based on the root sum square (RSS) method, among 16 combination models, the optimal combination model for OTL correction is the global model FES2014b by combing the regional model OSU.Chinasea.2010 (F14O). The RSS, which has reached 7.1 nms−2, is the minimum of the 16 combination models. Simulating with the F14O in the China Sea and adjacent areas, the gravity amplitude of the OTL is about 10 nms−2 in inland areas and > 50 nms−2 along the coastline. Especially in Southeastern China coastal areas and the southwestern coastal areas of the Korean Peninsula, the gravity amplitude of the OTL reaches about 80 nms−2. Moreover, the OTL changes drastically possibly owing to coastal topography. The results of this study provide a reference for selecting ocean tide models for high-precision analysis of continuous gravity observations in East China.
Hybrid warfare and counter-terrorism medicine
Authors: Tin Derrick , Barten Dennis G. , Granholm Fredrik , Kovtonyuk Pavlo , Burkle Frederick M. , Ciottone Gregory R. 
Published: February 2023

AbstractIntroductionMarch 9, 2022. An airstrike by Russian forces destroying a maternity hospital in Mariupol, Ukraine. The image of a severely injured pregnant woman covered in blood being stretchered away against the backdrop of destroyed buildings. Mutterings of the use of chemical weapons. This paper is a primer for healthcare personnel and health systems on hybrid warfare and counter-terrorism medicine.DiscussionWhile recent events and images arising from conflicts around the world represent a cruel hallmark in today’s history, attacks against healthcare facilities and innocent civilians are not new and continue to be perpetrated around the world. In war, the Geneva Convention protects civilians and healthcare institutions from harm but when war crimes are being committed and civilians knowingly targeted, parallels from a healthcare perspective can be drawn with terrorism events. Increasingly, civilian institutions and in particular the healthcare sector, are drawn into such conflicts and understanding the health system impact of hybrid warfare and other asymmetrical attack methods is of great importance.ConclusionThe field of Counter-Terrorism Medicine (CTM) explores the healthcare impacts of intentional, man-made attacks and much recent research and discussions around this topic are extremely relevant and applicable not just to the ongoing hybrid war in Ukraine, but to today’s threat climate all around us.
CR-twistor spaces over manifolds with $$G_2$$- and Spin(7)-structures
Authors: Fiorenza Domenico , Lê Hông Vân 
Published: February 2023

AbstractIn 1984 LeBrun constructed a CR-twistor space over an arbitrary conformal Riemannian 3-manifold and proved that the CR-structure is formally integrable. This twistor construction has been generalized by Rossi in 1985 form-dimensional Riemannian manifolds endowed with a$$(m-1)$$(m-1)-fold vector cross product (VCP). In 2011 Verbitsky generalized LeBrun’s construction of twistor-spaces to 7-manifolds endowed with a$${\mathrm {G_{2}}}$$G2-structure. In this paper we unify and generalize LeBrun’s, Rossi’s and Verbitsky’s construction of a CR-twistor space to the case where a Riemannian manifold (M, g) has a VCP structure. We show that the formal integrability of the CR-structure is expressed in terms of a torsion tensor on the twistor space, which is a Grassmannian bundle over (M, g). If the VCP structure on (M, g) is generated by a$${\mathrm {G_{2}}}$$G2- or$$\textrm{Spin}(7)$$Spin(7)-structure, then the vertical component of the torsion tensor vanishes if and only if (M, g) has constant curvature, and the horizontal component vanishes if and only if (M, g) is a torsion-free$${\mathrm {G_{2}}}$$G2or$$\textrm{Spin}(7)$$Spin(7)-manifold. Finally we discuss some open problems.
Droht der deutschen Wirtschaft eine Deindustrialisierung?
Authors:   ZG Überblick
Published: February 2023

ZusammenfassungNach der Coronapandemie wird die deutsche Wirtschaft durch den Angriffskrieg Russlands auf die Ukraine von einem weiteren exogenen Schock getroffen. Neben gestörten Lieferketten, fehlenden Rohstoffen und Fachkräften kommen nun Energieknappheit und Inflation hinzu und belasten die deutsche Wirtschaft stark. Die Unsicherheiten bei den Unternehmen nehmen weiter zu. Die Autor:innen des Zeitgesprächs diskutieren, ob die deutsche Industrie von einer Deindustrialisierung bedroht ist und welche Möglichkeiten es gibt, diese Krise möglichst gut zu überwinden.