bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhesus macaque social functioning is paternally, but not maternally, inherited by sons: potential implications for autism
Authors: Garner Joseph P. , Talbot Catherine F. , Del Rosso Laura A. , McCowan Brenda , Kanthaswamy Sreetharan , Haig David , Capitanio John P. , Parker Karen J. 
Published: July 2023

Abstract
Background
Quantitative autistic traits are common, heritable, and continuously distributed across the general human population. Patterns of autistic traits within families suggest that more complex mechanisms than simple Mendelian inheritance—in particular, parent of origin effects—may be involved. The ideal strategy for ascertaining parent of origin effects is by half-sibling analysis, where half-siblings share one, but not both, parents and each individual belongs to a unique combination of paternal and maternal half-siblings. While this family structure is rare in humans, many of our primate relatives, including rhesus macaques, have promiscuous breeding systems that consistently produce paternal and maternal half-siblings for a given index animal. Rhesus macaques, like humans, also exhibit pronounced variation in social functioning.

Methods
Here we assessed differential paternal versus maternal inheritance of social functioning in male rhesus macaque offspring (N = 407) using ethological observations and ratings on a reverse-translated quantitative autistic trait measurement scale. Restricted Maximum Likelihood mixed models with unbounded variance estimates were used to estimate the variance components needed to calculate the genetic contribution of parents as the proportion of phenotypic variance (σ2P) between sons that could uniquely be attributed to their shared genetics (σ2g), expressed as σ2g/σ2P (or the proportion of phenotypic variance attributable to genetic variance), as well as narrow sense heritability (h2).

Results
Genetic contributions and heritability estimates were strong and highly significant for sons who shared a father but weak and non-significant for sons who shared a mother. Importantly, these findings were detected using the same scores from the same sons in the same analysis, confirmed when paternal and maternal half-siblings were analyzed separately, and observed with two methodologically distinct behavioral measures. Finally, genetic contributions were similar for full-siblings versus half-siblings that shared only a father, further supporting a selective paternal inheritance effect.

Limitations
These data are correlational by nature. A larger sample that includes female subjects, enables deeper pedigree assessments, and supports molecular genetic analyses is warranted.

Conclusions
Rhesus macaque social functioning may be paternally, but not maternally, inherited by sons. With continued investigation, this approach may yield important insights into sex differences in autism’s genetic liability.
Real-time observation of phase transition from layered to spinel phase under electron beam irradiation
Authors: Seo Jong Hyeok , Park Joon Yong , Kim Yong-Il , Nam Ki Min , Jang Jae Hyuck , Kwon Ji-Hwan 
Published: July 2023

AbstractTransition metal hydroxides (TM(OH)2) have drawn significant attention for their potential applications in the environmental and energy field. In this study, we investigated the phase transition of cobalt hydroxide (Co(OH)2) under electron beam irradiation using in situ high-resolution transmission electron microscopy. Both the α- and β-Co(OH)2 phases underwent a phase transition to a spinel Co3O4 phase, forming nanograins with a porous morphology. However, the α-Co(OH)2 showed a faster phase transition and dramatic volume shrinkage during the phase transition. Our results provide a detailed explanation of the mechanism behind the deterioration of the layered structure and the emergence of defects during the phase transition.
How variable are Birkeland currents?
Authors: Burchill Johnathan K. 
Published: July 2023

Abstract
I address the problem of estimating the time-rate-of-change of high-latitude Birkeland currents by using a string-of-pearls formation of satellites. Space series are calculated by linear interpolation of measurements made at the revisit times of the satellites. A lower bound on the total time derivative can be estimated as a function of distance along the orbit. Space series of the vertical component of electric current density, used as a proxy for field-aligned (Birkeland) current density at high latitude, are estimated from the along-track spatial derivative of Swarm magnetic field measurements residual to the CHAOS-7 internal field model. The results reveal non-negligible total time derivatives over periods shorter than 2 mins. Auroral Birkeland current densities derived from single-satellite traversals of magnetic field gradients can change dramatically in the time it takes a single satellite to cross a large-scale current system. In one example, during an overflight by the Swarm satellites of the THEMIS Fort Yukon all-sky imager on 1 December 2013, the vertical current density poleward of a visually quiescent auroral arc changes from $$\sim 0.3\ \mu \,\hbox {A}/\hbox {m}^{2}$$

∼
0.3

μ

A
/

m
2

upward to $$\sim 1.0\ \mu \,\hbox {A}/\hbox {m}^{2}$$

∼
1.0

μ

A
/

m
2

downward in 13.7 s (corresponding to an along-track separation of Swarm A and B of 104 km). The variability of Auroral Birkeland currents, between 25 November 2013 and 31 December 2013, as estimated by the median of $$|dj_z/dt|$$

|
d

j
z

/
d
t
|

, reaches $$15\ \hbox {nA}/\hbox {m}^{2}/\textrm{s}$$

15

nA
/

m
2

/
s

in the northern dayside auroral zone and exceeds $$30\ \hbox {nA}/\hbox {m}^{2}/\textrm{s}$$

30

nA
/

m
2

/
s

in the pre-noon sector of the southern hemisphere.

Graphic Abstract
Information and communication integration in smart factory design
Authors: Fauska Christian , Kniežová Jaroslava 
Published: July 2023

Strategic smart factory design is essential to utilize Industry 4.0 technologies in production environments effectively. Although a series of earlier reviews in the context of smart manufacturing have been published, so far none addresses smart factory design, i. e. the planning and operation of smart factories. This review provides an overview of recent research in the field by systematizing opportunities, risks and success factors of smart factory design as available from recent empirical studies (2018-2022). Businesses are informed how smart factory design should be approached and implemented to realize cost advantages and increase competitiveness. Academic research benefits of a classification of relevant issues and open research fields are outlined.
The relationship between climate change and malaria in South-East Asia: A systematic review of the evidence
Authors: Rahmani Ardhi Arsala , Susanna Dewi , Febrian Tommi 
Published: July 2023

Background: Climatic change is an inescapable fact that implies alterations in seasons where weather occurrences have their schedules shift from the regular and magnitudes intensify to more extreme variations over a multi-year period. Southeast Asia is one of the many regions experiencing changes in climate and concurrently still has endemicities of malaria. Given that previous studies have suggested the influence of climate on malaria’s vector the Anopheles mosquitoes and parasite the Plasmodium group, this study was conducted to review the evidence of associations made between malaria cases and climatic variables in Southeast Asia throughout a multi-year period. Methods: Our systematic literature review was informed by the PRISMA guidelines and registered in PROSPERO: CRD42022301826 on 5th February 2022. We searched for original articles in English and Indonesian that focused on the associations between climatic variables and malaria cases. Results: The initial identification stage resulted in 535 records of possible relevance and after abstract screening and eligibility assessment we included 19 research articles for the systematic review. Based on the reviewed articles, changing temperatures, precipitation, humidity and windspeed were considered for statistical association across a multi-year period and are correlated with malaria cases in various regions throughout Southeast Asia. Conclusions: According to the review of evidence, climatic variables that exhibited a statistically significant correlation with malaria cases include temperatures, precipitation, and humidity. The strength of each climatic variable varies across studies. Our systematic review of the limited evidence indicates that further research for the Southeast Asia region remains to be explored.
The Diversity Heuristic: How Team Demographic Composition Influences Judgments of Team Creativity
Authors: Proudfoot Devon , Berry Zachariah , Chang Edward H. , Kay Min B. 
Published: July 2023

Despite mixed evidence for the relationship between demographic diversity and creativity, we propose that observers hold a lay belief that demographic diversity increases creativity and apply this lay belief in judgments about teams and their creative work. Across eight preregistered studies (n = 5,530), we find that observers judge teams diverse in terms of race and gender to be more creative than teams homogeneous in terms of race and gender, including in incentive-compatible predictions made about real teams competing in a creativity challenge. We also find that products attributed to demographically diverse teams are evaluated as more creative compared with identical products attributed to demographically homogenous teams. Mediation analyses provide evidence consistent with the notion that people perceive demographic diversity (i.e., social category differences) to be correlated with cognitive diversity (i.e., difference of perspectives), and this belief contributes to attributions of greater creativity to diverse teams and the ideas they generate. We can also turn off the perceived association between demographic diversity and creativity by directly manipulating people’s perceptions of team cognitive diversity. Furthermore, we find evidence of a curvilinear relationship between the proportion of racial minorities or women in a group and judgments of the group’s creativity. Together, our results suggest that the popular uptake of the belief that diversity boosts creativity may impact how creativity is identified in organizational contexts. This paper was accepted by Yuval Rottenstreich, behavioral economics and decision analysis. Funding: This research was supported by funds from the School of Industrial and Labor Relations, Cornell University, and Harvard Business School, Harvard University, including a grant from the Cornell Center for Advanced Human Resource Studies. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4862 .
Neutrophil extracellular traps involved in the pathogenesis of IgA vasculitis: Confirmed in two IgAV rat models
Authors: Chen Xiu-Qi , Zou Jia-Sen , Tu Li , Yun Xiang , Qin Yuan-Han 
Published: July 2023

Background
Neutrophil extracellular traps (NETs) have been found to play a role in the development of autoimmune diseases. In the past two years, studies have demonstrated a significantly increase of NETs in skin tissues during the early stages of IgAV, indicating their involvement in disease activity among children with IgAV. However, the presence of NETs in IgAV animal models has not yet been reported. The objective of this study is to investigate whether NETs are involved in the pathogenesis of IgA vasculitis (IgAV) rats.

Methods
Twenty-four SD rats were randomly divided into three groups: the ovalbumin group, the gliadin group, and the control group. The IgAV rat models were established administering Indian ink with ovalbumin (ovalbumin group) or gliadin (gliadin group) with Freund’s complete adjuvant. The cell-free DNA (cf-DNA) was quantified by using dsDNA quantification kit, while the levels of Immunoglobulins, complement C3 and myeloperoxidase-DNA (MPO-DNA) in serum were tested using enzyme linked immunosorbent assay (ELISA). The IgA, complement C3 and NETs in tissues were detected through multiple immunofluorescences.

Results
Both the ovalbumin group and gliadin group showed IgA and C3 deposition in various tissues, including the glomerular mesangial region, skin, and digestive tract, while the control group showed no such deposition. The levels of circulatory cf-DNA and MPO-DNA, which are components of NETs, were significantly elevated in both ovalbumin and gliadin groups compared with the control group. Furthermore, the presence of NETs were found in gastrointestinal and renal tissues of the ovalbumin and gliadin groups, but not in the control group.

Conclusions
IgAV model rat can be established through the combination of ovalbumin and gliadin with Indian ink and Freund’s complete adjuvant. This study provides the first confirmation that NETs are involved in the pathogenesis of IgAV rat.
Use of a mobile-assisted telehealth regimen to increase exercise (MATRIX) in transplant candidates – A home-based prehabilitation pilot and feasibility trial
Authors: Duarte-Rojo Andres , Bloomer Pamela M. , Grubbs Rachel K. , Stine Jonathan G. , Ladner Daniela , Hughes Christopher B. , Dunn Michael A. , Jakicic John M. 
Published: July 2023

ABSTRACT

Introduction.
Physical fitness assessed by the liver frailty index (LFI) and 6-minute walk test (6MWT) informs the prognosis of liver transplant (LT) candidates although there is limited data on its reversibility following a prehabilitation. On a home-based exercise trial, we aimed to improve LFI and 6MWT and to investigate trial feasibility and intervention adherence.

Methods.
LT candidates with cirrhosis wore a personal activity tracker (PAT) and used EL-FIT (Exercise & Liver FITness app) for 14 weeks, including a 2-week technology acclimation run-in. The 12-week intervention consisted of EL-FIT plus PAT and 15-/30-min weekly calls with a physical activity coach aiming to complete ≥2 video-training sessions/week, or ≥500 step/day baseline increase for ≥8 weeks. We defined feasibility as ≥66% of subjects engaging in the intervention phase and adherence as ≥50% subjects meeting training endpoint.

Results.
31 patients (61±7 years, 71% female, MELD 17±5, ∼33% frail) consented and 21 (68%) started the intervention. In the 15 subjects who completed the study, LFI improved from 3.84±0.71 to 3.47±0.90 (p=0.03) and 6MWT from 318±73 to 358±64 m (p=0.005). Attrition reasons included death (n=4) and surgery (n=2). There was 57% adherence, better for videos than for walking, although daily steps significantly increased (3508 vs. baseline:1260) during best performance week. One adverse event was attributed to the intervention.

Discussion.
Our clinical trial meaningfully improved LFI by 0.4 and 6MWT by 41 m and met feasibility/adherence goals. In-training daily step increase supported physical self-efficacy and intervention uptake, but maintenance remained a challenge despite counseling.
Una nueva perspectiva en el cribado del cáncer de próstata
Authors: Filella Xavier , González Álvaro , Augé Josep Maria , Barco Antonio , Carbonell Rosa , Gaspar María Jesús , Martínez-Peinado Antonio , Pérez Barrios Clara , Sánchez-Carbayo Marta , Santotoribio José Diego , Trapé Jaume 
Published: July 2023

Resumen
El cribado del cáncer de próstata mediante la medida del antígeno específico de la próstata (PSA) ha sido objeto de una intensa polémica. Los beneficios derivados en cuanto a reducción en mortalidad del cribado organizado del cáncer de próstata se han acompañado de un importante sobrediagnóstico, que se ha traducido en tratamientos innecesarios y numerosos efectos adversos. Por ello, las recomendaciones de las sociedades científicas han sido cada vez más restrictivas. En los últimos años se han hecho diversas propuestas para reconsiderar el enfoque sobre el cribado del cáncer de próstata, con objeto de superar la oposición entre cribar a todo el mundo o no cribar a nadie y a reconsiderar el PSA como una herramienta que permita un balance favorable entre beneficios y riesgos. En este contexto, hay que destacar la propuesta que la European Association of Urology dirigía a la Comisión Europea replanteando el cribado del cáncer de próstata en función de la medida de un PSA basal. Recientemente, la Comisión Europea ha recomendado la implementación de programas organizados para el cribado del cáncer de próstata para hombres de hasta 70 años basado en medidas de PSA en combinación con la resonancia magnética como prueba de seguimiento.
A Transitional Institution: Schleiermacher on the Possibility and Limits of the Modern Christian State
Authors: Vander Schel Kevin M. 
Published: July 2023

AbstractThe early nineteenth century was a time between empires in German-speaking lands, following the collapse of the holy Roman empire in 1806. This was also the time at which modern concepts of nations, nationalism, and the state entered theological discourse, bound together with emerging notions of world historical progress. From this time until the First World War, the task of conceptualizing national identity and the nature of the ‘Christian state’ became a pressing theological problem. This essay seeks to locate Schleiermacher’s reflections on the Christian state within this developing problematic. Schleiermacher’s philosophical and theological works closely engaged emerging ideas of the nation, state, and historical progress. However, he departed from the more totalizing affirmations of national spirit and the Christian state of many of his contemporaries, arguing for a more limited conception of the state as a point of transition in the ongoing historical development of the reign of God.
Avatar Intervention for cannabis use disorder in a patient with schizoaffective disorder: A case report
Authors: Giguère Sabrina , Dellazizzo Laura , Beaudoin Mélissa , Lapierre Marie-Andrée , Villeneuve Marie , Phraxayavong Kingsada , Potvin Stéphane , Dumais Alexandre 
Published: July 2023

Considering the harmful effects of cannabis on individuals with a severe mental disorder and the limited effectiveness of current interventions, this case report showcases the beneficial results of a 10-session Avatar intervention for cannabis use disorder (CUD) on a polysubstance user with a comorbid schizoaffective disorder. Virtual reality allowed the creation of an Avatar representing a person significantly related to the patient’s drug use. Avatar intervention for CUD aims to combine exposure, relational, and cognitive behavioral therapies while practicing real-life situations and learning how to manage negative emotions and cravings. Throughout therapy and later on, Mr. C managed to maintain abstinence from all substances. Also, an improvement in the severity of CUD as well as a greater motivation to change consumption, were observed after therapy. As observed by his mother, his psychiatrist, and himself, the benefits of Avatar intervention for CUD extended to other spheres of his life. The drastic results observed in this patient could be promising as an alternative to the current treatment available for people with a dual diagnosis of cannabis use disorder and psychotic disorder, which generally lack effectiveness. A single-blind randomized control trial comparing the treatment with a classical intervention in a larger sample is currently underway to evaluate whether the results are reproducible on a larger sample.
Nonvascularized Double Metatarsal Transfer After Excision of Epithelioid Hemangioma of Hand
Authors: Raj Pallapati Samuel C. , Joyson D R Kathir , Kiran Sasi P. , Thomas Binu Prathap , Prabhu Anne Jennifer 
Published: July 2023

Case:
Epithelioid hemangioma (EH) is an uncommon, benign, locally aggressive neoplasm, and it may present as multifocal lytic lesions with soft tissue involvement in the hand. We report the midterm follow-up of a patient with recurrent EH of the hand that was reconstructed successfully, with a nonvascularized double metatarsal transfer, after tumor excision. To the best of the authors' knowledge, this is the first case report where a nonvascularized double metatarsal transfer has been used successfully after tumor resection.

Conclusion:
Osteoarticular replacement with matched metatarsal transfer after en bloc resection may be used successfully for reconstruction, after the resection of EH involving the metacarpal.
Fluid-Solid Coupling Mechanism of Shale Hydraulic Fracture Propagation Based on True Triaxial Test and Numerical Analysis
Authors: Zhang Bohu , Hu Yao , Hu Xinxin , Xu Qian 
Published: July 2023

Abstract
Hydraulic fracture propagation has a great influence on reservoir reconstruction in shale gas exploitation. The study on mechanism of hydraulic fracture propagation is important. Based on the fluid-solid coupling theory, the propagation criterion under hydraulic pressure of shale is deduced in this paper. In combination with large-scale true triaxial experiment and numerical simulation, the law of hydraulic fracture propagation is researched, and the mechanism of hydraulic fracture propagation is obtained. The results show that shale will produce tensile failure and shear failure under the interaction of water pressure and ground stress. Acoustic emission monitoring data show that the initiation of microfracture is related to water pressure. When the fracture occurs, the number of acoustic emission events increases, and the water pressure drops sharply. Tensile failure occurs mainly at the crack tip, while shear failure occurs mainly at the weak structural plane. When bedding is encountered, hydraulic fracture will be diverted and spread along the bedding. If the strength of the cement inside the bedding is high, the hydraulic fracture passes directly through the weak structural plane. In this paper, the mechanism of shale hydraulic fracture propagation is studied, which has a certain theoretical and practical significance for shale gas fracturing effect evaluation and reservoir stimulation.
Paleo-Mesoproterozoic Rifting Along the Margins of Archean Bundelkhand Craton North-Central India: Timing the Event from U–Pb SHRIMP Zircon Data and Their Geodynamic Implications
Authors: Shrivastava Anuj K. , Raza Mohammad B. , Saha Lopamudra , Yi Keewook , Nasipuri Pritam , Pati Jayanta K. 
Published: July 2023

AbstractIn this article, novel geochronological (U–Pb SHRIMP) and geochemical data are presented from the lowermost sandstone unit (Par formation), basement granites of Gwalior Basin and sandstones from the Bhopal Basin, located along margins of the Archaean Bundelkhand Craton. The geochemical variation diagrams imply that sandstone units in the Gwalior and Bhopal Basins were deposited in rift-induced passive margin tectonic settings. In contrast to the magmatic features that are preserved in the zircons of granite of the Gwalior Basins, detrital zircons from sandstones of both basins are fragmentary and polymodal in size. The magmatic zircon grains from the basement granites yield a 207Pb/206Pb concordant age of 2538 ± 2 Ma. A group of detrital zircons from the sandstone of the Gwalior Basin with concentric magmatic zonation yield a weighted mean average age of 2564 ± 24 Ma. The detrital zircons from Gwalior Basin exhibit a patchy U-Th distribution overgrowing the magmatic zonation yield average age of 2044 ± 2 Ma. The detrital zircons from the Bhopal basin yield three distinct concordant ages of 2511 ± 5, 1694 ± 6, and 1355±9 Ma. The presence of ~2540 Ma concordant zircon population with concentric zonation in the sandstone of Bhopal Basin suggests their derivation from the granite of similar age. Therefore, an extension of Bundelkhand Craton granite below the Bhopal Basin is suggested. The 2500 Ma ages from the Gwalior granites are linked to global magmatic activity leading to the stabilization of extended Ur at ~2500 Ma. The 2048 and 1355 Ma ages from the Gwalior and Bhopal Basins, respectively, are concluded as the maximum depositional age (MDA) of the lowermost stratigraphic units within the basins. The MDAs are concluded to be the timings of passive margin basin formations along margins of the Bundelkhand Craton during extended Ur and Nuna or Columbia disintegration, respectively, during plume-driven tectonics.