bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geographic variation in urinary tract and genital cancers in Iran: a hypothesis involving exposure to solar radiation
Authors: Khanjani Narges , Moradabadi Alireza , Najafi Esmail , Hayati Bagher , Abdollahi Reza 
Published: April 2023

Abstract
Objective
Sunlight and vitamin D intake are considered as essential elements for human health. Insufficient intake of this vitamin is one of the causes of various cancers and some other diseases. The aim of this study was to investigate the relation between bladder, prostate, cervical and ovarian cancers with solar ultraviolet exposure in Iran. In this ecological study, data from 30 provinces were studied and analyzed by correlation and linear regression tests in SPSS software version 22. Physical activity, gender, human development index, lung cancer and altitude were adjusted at population level.

Results
The incidence of bladder cancer in both sexes was inversely related to ultraviolet radiation, but it was significant only in men. Unlike bladder cancer, the incidence of cervical cancer showed a positive relation with ultraviolet radiation. No relation was found between the incidence of prostate and ovarian cancers with ultraviolet radiation. Among the adjusting variables, the incidence of lung cancer (surrogate for smoking) in women had the highest coefficient in the linear regression model.
Advancing methods in big data capture, integration, classification and liberation
Authors: Zdravevski Eftim , Pires Ivan Miguel 
Published: April 2023

AbstractThis special issue focuses on the importance of advancing research techniques for managing and analyzing data in today’s data-rich landscape. In this editorial, we set the context and invite contributions for a BMC Collection of articles titled ‘Advancing methods in data capture, integration, classification and liberation’. The collection emphasizes the need for efficient ways to standardize, cleanse, integrate, enrich, and liberate data, highlighting recent advancements in research methods and industrial technologies that facilitate this. We invite researchers to submit their best work to the collection and to showcase the latest advancements and additions to research techniques.
Glypican-3 targeted positron emission tomography detects sub-centimeter tumors in a xenograft model of hepatocellular carcinoma
Authors: Labadie Kevin P. , Lehnert Adrienne L. , Kenoyer Aimee L. , Hamlin Donald K. , Ludwig Andrew D. , Utria Alan F. , Daniel Sara K. , Mihailovic Tara N. , Prossnitz Alexander , Orozco Johnnie J. , Li Yawen , Wilbur D. Scott , Miyaoka Robert S. , Park James O. 
Published: April 2023

Abstract
Background
Early intrahepatic recurrence is common after surgical resection of hepatocellular carcinoma (HCC) and leads to increased morbidity and mortality. Insensitive and nonspecific diagnostic imaging contributes to EIR and results in missed treatment opportunities. In addition, novel modalities are needed to identify targets amenable for targeted molecular therapy. In this study, we evaluated a zirconium-89 radiolabeled glypican-3 (GPC3) targeting antibody conjugate (89Zr-αGPC3) for use in positron emission tomography (PET) for detection of small, GPC3+ HCC in an orthotopic murine model. Athymic nu/J mice received hepG2, a GPC3+ human HCC cell line, into the hepatic subcapsular space. Tumor-bearing mice were imaged by PET/computerized tomography (CT) 4 days after tail vein injection of 89Zr-αGPC3. Livers were then excised for the tumors to be identified, measured, bisected, and then serially sectioned at 500 μm increments. Sensitivity and specificity of PET/CT for 89Zr-αGPC3-avid tumors were assessed using tumor confirmation on histologic sections as the gold standard.

Results
In tumor-bearing mice, 89Zr-αGPC3 avidly accumulated in the tumor within four hours of injection with ongoing accumulation over time. There was minimal off-target deposition and rapid bloodstream clearance. Thirty-eight of 43 animals had an identifiable tumor on histologic analysis. 89Zr-αGPC3 immuno-PET detected all 38 histologically confirmed tumors with a sensitivity of 100%, with the smallest tumor detected measuring 330 μm in diameter. Tumor-to-liver ratios of 89Zr-αGPC3 uptake were high, creating excellent spatial resolution for ease of tumor detection on PET/CT. Two of five tumors that were observed on PET/CT were not identified on histologic analysis, yielding a specificity of 60%.

Conclusions
89Zr-αGPC3 avidly accumulated in GPC3+ tumors with minimal off-target sequestration. 89Zr-αGPC3 immuno-PET yielded a sensitivity of 100% and detected sub-millimeter tumors. This technology may improve diagnostic sensitivity of small HCC and select GPC3+ tumors for targeted therapy. Human trials are warranted to assess its impact.
Rotating behind security: an enhanced authentication protocol for IoT-enabled devices in distributed cloud computing architecture
Authors: Wu Tsu-Yang , Kong Fangfang , Meng Qian , Kumari Saru , Chen Chien-Ming 
Published: April 2023

AbstractWith the continuous progress of the Internet of Things (IoT) technology, IoT devices have gradually penetrated all aspects of life. However, due to rapid data growth, IoT devices with limited memory resources cannot store massive data. Cloud computing is an Internet-centric network that can provide security services and data storage. The combination of IoT devices with cloud computing considerably promotes resource sharing, facilitates users’ access to information at any time, and provides users with corresponding cloud computing services on time. Because the information transmitted through public channels is easily intercepted, tampered with, and eavesdropped on by malicious attackers. As a result, users’ and servers’ private information are disclosed. Numerous scholars have proposed different authentication protocols in this environment to protect the communications between users and servers. Amin et al. devised a smart card based authentication protocol. Unfortunately, Kang et al. demonstrated that their protocol was insecure. Huang et al. discovered Kang et al.’s improvement also has security flaws and then designed a protocol to enhance security. In this paper, we first show that Huang et al.’s protocol cannot resist privileged insider and temporary value disclosure attacks. Afterward, we propose an enhanced protocol based on their protocol. Finally, we use formal/informal security analysis to demonstrate the security of the improved protocol. The comparison results are indicated that our protocol has lower computational and communication costs under the same security level.
Factors associated with physical activity participation among children: a systematic review protocol
Authors: Srivastav Prateek , Vaishali K. , Rajwar Eti , Broadbent Suzanne , Bhat H. Vinod 
Published: April 2023

AbstractBackgroundReduced physical activity (PA) is one of the significant health concerns in adults and children alike. Despite the proven benefits of PA, most children, globally, do not meet the weekly criteria of enough PA to maintain health. The proposed systematic review is the review of the factors and will provide information on the factors associated with PA participation in children.MethodsThe proposed systematic review will be conducted based on the methodology from the Cochrane Handbook for Systematic Reviews of Interventions. We will include observational studies (cross-sectional, case–control, and cohort studies), randomized controlled trials (RCTs), and non-randomized study designs for information on factors associated with PA participation among children. Studies with participants in the age range of 5–18 years, indulging in physical activity of 60 min per day for a minimum of 3 days a week, will be included. Studies including differently abled children, children under medical treatment, and those taking medications for illnesses such as neurological, cardiac, and mental health conditions will be excluded from the review. We will search MEDLINE (via PubMed and Web of Science), Scopus, EMBASE, CINAHL, Cochrane CENTRAL, and PEDro for English language publications published from the inception till October 2022. For additional studies, we will search websites such as the Australian Association for Adolescent Health International Association for Adolescent Health and a reference list of the included publications. Selection of studies, data extraction, and quality assessment of the included studies will be performed in duplicate. Quality assessment of the included studies will be performed using the Cochrane Risk of Bias tool (ROB-II) for RCTs, New-Castle Ottawa, for observational studies, and ROBINS-I (Risk of Bias for Non-Randomized studies of Interventions) for non-randomized study designs.DiscussionThe proposed systematic review and meta-analysis will present a summary of the available evidence on factors associated with PA participation in children. The findings of this review will provide new insights into how exercise providers can improve PA participation among children and can also help healthcare workers, clinicians, researchers, and policymakers to plan long-term interventions targeting child health.Systematic review registrationPROSPERO CRD42021270057.
A systematically biosynthetic investigation of lactic acid bacteria reveals diverse antagonistic bacteriocins that potentially shape the human microbiome
Authors: Zhang Dengwei , Zhang Jian , Kalimuthu Shanthini , Liu Jing , Song Zhi-Man , He Bei-bei , Cai Peiyan , Zhong Zheng , Feng Chenchen , Neelakantan Prasanna , Li Yong-Xin 
Published: April 2023

AbstractBackgroundLactic acid bacteria (LAB) produce various bioactive secondary metabolites (SMs), which endow LAB with a protective role for the host. However, the biosynthetic potentials of LAB-derived SMs remain elusive, particularly in their diversity, abundance, and distribution in the human microbiome. Thus, it is still unknown to what extent LAB-derived SMs are involved in microbiome homeostasis.ResultsHere, we systematically investigate the biosynthetic potential of LAB from 31,977 LAB genomes, identifying 130,051 secondary metabolite biosynthetic gene clusters (BGCs) of 2,849 gene cluster families (GCFs). Most of these GCFs are species-specific or even strain-specific and uncharacterized yet. Analyzing 748 human-associated metagenomes, we gain an insight into the profile of LAB BGCs, which are highly diverse and niche-specific in the human microbiome. We discover that most LAB BGCs may encode bacteriocins with pervasive antagonistic activities predicted by machine learning models, potentially playing protective roles in the human microbiome. Class II bacteriocins, one of the most abundant and diverse LAB SMs, are particularly enriched and predominant in the vaginal microbiome. We utilized metagenomic and metatranscriptomic analyses to guide our discovery of functional class II bacteriocins. Our findings suggest that these antibacterial bacteriocins have the potential to regulate microbial communities in the vagina, thereby contributing to the maintenance of microbiome homeostasis.ConclusionsOur study systematically investigates LAB biosynthetic potential and their profiles in the human microbiome, linking them to the antagonistic contributions to microbiome homeostasis via omics analysis. These discoveries of the diverse and prevalent antagonistic SMs are expected to stimulate the mechanism study of LAB’s protective roles for the microbiome and host, highlighting the potential of LAB and their bacteriocins as therapeutic alternatives.
Self-dehumanization and other-dehumanization toward students with special educational needs: examining their prevalence, consequences and identifying solutions—a study protocol
Authors: Sin Kuen-Fung , Yang Lan , Ye Frank Tian-Fang 
Published: April 2023

Abstract
Background
Students with special educational needs (SEN) often face dehumanization, which negatively impacts their mental health, daily functioning, and educational outcomes. This study seeks to address the research gap in dehumanization literature by examining the prevalence, dynamics, and consequences of self-dehumanization and other-dehumanization among SEN students. Moreover, by utilizing psychological experiments, the study aims to identify potential intervention strategies and make recommendations to minimize the negative psychological consequences derived from the dual model of dehumanization.

Methods
This two-phase, mixed-methods study incorporates cross-sectional surveys and quasi-experimental designs. Phase 1 investigates the self-dehumanization of SEN students and other-dehumanization from non-SEN peers, teachers, parents, and the public. Phase 2 involves four experimental studies to evaluate the effectiveness of interventions emphasizing human nature and uniqueness in reducing self-dehumanization and other-dehumanization of SEN students, as well as their associated negative consequences.

Discussion
The study fills a research gap by examining dehumanization in SEN students, applying dyadic modeling, and identifying potential solutions to ameliorate dehumanization and its negative consequences. The findings will contribute to the advancement of the dual model of dehumanization, increase public awareness and support for SEN students in inclusive education, and promote changes in school practice and family support. The 24-month study in Hong Kong schools is expected to provide significant insights into inclusive education in school and community settings.
Circulating bone morphogenetic protein 8A is a novel biomarker to predict advanced liver fibrosis
Authors: Marañón Patricia , Isaza Stephania C. , Fernández-García Carlos Ernesto , Rey Esther , Gallego-Durán Rocío , Montero-Vallejo Rocío , de Cía Javier Rodríguez , Ampuero Javier , Valverde Ángela M. , Romero-Gómez Manuel , García-Monzón Carmelo , González-Rodríguez Águeda 
Published: April 2023

Abstract
Background & Aims
Advanced hepatic fibrosis is the main risk factor of liver-related morbidity and mortality in patients with chronic liver disease. In this study, we assessed the potential role of bone morphogenetic protein 8A (BMP8A) as a novel target involved in liver fibrosis progression.

Methods
Histological assessment and BMP8A expression were determined in different murine models of hepatic fibrosis. Furthermore, serum BMP8A was measured in mice with bile duct ligation (BDL), in 36 subjects with histologically normal liver (NL) and in 85 patients with biopsy-proven non-alcoholic steatohepatitis (NASH): 52 with non- or mild fibrosis (F0-F2) and 33 with advanced fibrosis (F3-F4). BMP8A expression and secretion was also determined in cultured human hepatocyte-derived (Huh7) and human hepatic stellate (LX2) cells stimulated with transforming growth factor ꞵ (TGFꞵ).

Results
Bmp8a mRNA levels were significantly upregulated in livers from fibrotic mice compared to control animals. Notably, serum BMP8A levels were also elevated in BDL mice. In addition, in vitro experiments showed increased expression and secretion to the culture supernatant of BMP8A in both Huh7 and LX2 cells treated with TGFꞵ. Noteworthy, we found that serum BMP8A levels were significantly higher in NASH patients with advanced fibrosis than in those with non- or mild fibrosis. In fact, the AUROC of circulating BMP8A concentrations to identify patients with advanced fibrosis (F3-F4) was 0.74 (p˂0.0001). Moreover, we developed an algorithm based on serum BMP8A levels that showed an AUROC of 0.818 (p˂0.0001) to predict advanced fibrosis in NASH patients.

Conclusion
This study provides experimental and clinical evidence indicating that BMP8A is a novel molecular target linked to liver fibrosis and introduces an efficient algorithm based on serum BMP8A levels to screen patients at risk for advanced hepatic fibrosis.
A comprehensive assessment method for the health status of bronzes unearthed at archaeological sites
Authors: Li Juan , Li Li , Xie Zhenbin , Xiang Jiankai , Zhao Xichen , Xiao Qing , Ling Xue 
Published: April 2023

Abstract
As one of the common physical materials in Chinese archaeological excavations, ancient bronzes are an essential basis for studying the development of Chinese bronze culture, which is of great significance for exploring the development law of ancient human civilization and reconstructing ancient human society. As China’s infrastructure advances, the number of bronzes unearthed by archaeological excavations continues to increase. However, environmental damage to artefacts is very complex, whether the buried environment of the artefacts or the above-ground environment when the artefacts are unearthed, leading to different health problems for the excavated bronzes. A scientific assessment of these bronzes needs to be carried out prior to extraction to inform staff how they should be extracted, moved, and transported and how they should be restored afterwards. In response to the above problems, this paper takes excavated bronzes from archaeological sites as the research object and, by analysing and studying the relevant industry standards and the disease characteristics of bronzes, establishes a three-tier indicator framework for assessing the health of bronzes in a layer-by-layer refinement and proposes quantitative indicators with typical correlations. Through extensive research and testing, we screened out efficient, non-destructive, convenient and reliable assessment and testing methods and assessment models that combine subjective and objective aspects suitable for archaeological sites. On this basis, the paper achieves a scientific and practical assessment of the health status of bronzes excavated from archaeological sites. After repeated experiments, a set of comprehensive methods for quickly and conveniently assessing the health status of excavated bronzes was proposed for the first time and successfully applied to the archaeological excavation site of Sanxingdui site in Guanghan City, Sichuan Province, China.
Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine
Authors: Lopes Daniela , Lopes Joana , Pereira-Silva Miguel , Peixoto Diana , Rabiee Navid , Veiga Francisco , Moradi Omid , Guo Zhan-Hu , Wang Xiang-Dong , Conde João , Makvandi Pooyan , Paiva-Santos Ana Cláudia 
Published: April 2023

AbstractA bio-inspired strategy has recently been developed for camouflaging nanocarriers with biomembranes, such as natural cell membranes or subcellular structure-derived membranes. This strategy endows cloaked nanomaterials with improved interfacial properties, superior cell targeting, immune evasion potential, and prolonged duration of systemic circulation. Here, we summarize recent advances in the production and application of exosomal membrane-coated nanomaterials. The structure, properties, and manner in which exosomes communicate with cells are first reviewed. This is followed by a discussion of the types of exosomes and their fabrication methods. We then discuss the applications of biomimetic exosomes and membrane-cloaked nanocarriers in tissue engineering, regenerative medicine, imaging, and the treatment of neurodegenerative diseases. Finally, we appraise the current challenges associated with the clinical translation of biomimetic exosomal membrane-surface-engineered nanovehicles and evaluate the future of this technology.
Evaluating an emotion coaching programme for parents of young adolescents attending Child Adolescent Mental Health Services (CAMHS) in New Zealand: protocol for a multi-site feasibility trial including co-design with service users
Authors: Mansoor Zara , Stanley James , Fortune Sarah , Havighurst Sophie , Bell Elliot 
Published: April 2023

Abstract
Background
Early adolescence is a time of increased vulnerability for the development of common mental health conditions such as anxiety and depression (internalising outcomes). Current treatments such as cognitive-behavioural therapy and antidepressant medication are focused on the individual and have small effect sizes, particularly in real-world clinical settings such as the public Child Adolescent Mental Health Services (CAMHS). Parents are an important and under-utilised resource in treating these conditions in young adolescents. Teaching parents how to respond to their young person’s emotions can improve emotion regulation and reduce internalising outcomes. One emotion-focused programme for parents of this age group is Tuning in to Teens (TINT). This is a structured, manualised skills group for parents only focused on teaching skills to coach young people through their emotional experiences. This study aims to investigate the impact of TINT in the clinical setting of publicly funded CAMHS in New Zealand.

Methods
The trial will evaluate the feasibility of a two-arm multi-site randomised control trial (RCT). Participants will be 10–14-year-olds referred to CAMHS in Wellington, New Zealand, with anxiety or depression, and their parents or guardians. Arm 1 will be parents attending and implementing TINT (in addition to the usual care received at CAMHS). Arm 2 will be usual care only. TINT groups will be facilitated by CAMHS clinicians who have been trained in the programme and will be delivered over 8 weekly sessions. Prior to the RCT, a co-design methodology will be used with service users to inform outcome measures used in the trial. A group of service users meeting the RCT criteria will be recruited to take part in workshops to help determine their priority outcomes. Measures based on the results of workshops will be included in the outcome measures. The primary feasibility outcomes will be the recruitment and retention of participants, acceptability of the intervention for service users and clinicians and acceptability of outcome measures.

Discussion
There is a need to improve outcomes for the treatment of adolescent anxiety and depression. TINT is a programme with the potential to enhance outcomes for those accessing mental health services by providing targeted support to parents of adolescents. This trial will inform whether a full RCT is feasible to evaluate TINT. Including service users in the design will increase its relevance of an evaluation in this setting.

Trial registration
The Australian New Zealand Clinical Trials Registry (ACTRN): ACTRN12622000483752. Registered on 28 March 2022.