bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Cu2-x Ni0.05 S (x=0.05,0.25,0.30) Compounds and Study of Single Crystals
Authors: Hashimov Kh. Kh. 
Published: August 2023

In the article, considering the research studies of many scientists and also on the basis of practical applications, the distribution diagram of copper and sulfur atoms in the phase lattice of the crystal, the structure transformation diagram, the elemental lattice hexagonal and crystallographic data were examined and important results were obtained. Analysis of the studies performed shows that some conflicting results in roentgenographic studies on these compounds are related to obtaining these samples by different methods.
Our goal is to obtain single crystals of the compounds Cu2-xNi0.05S (x=0.05,0.25,0.30) and draw the lauegrams and debayograms of those crystals. Then the results were analyzed.
During the research, it was found that it is possible to buy single crystals of compounds based on the analysis of existing methods and selection of the optimal method. As a result of the research, the suitable lauegrams of the single crystals obtained by the Bridgman method and the microstructures of the samples were determined and the possibilities of application were determined.
Receiver operating characteristic curves in the crime linkage context: Benefits, limitations, and recommendations
Authors: Ewanation Logan , Bennell Craig , Tonkin Matthew , Santtila Pekka 
Published: August 2023

AbstractDeciding whether two crimes have been committed by the same offender or different offenders is an important investigative task. Crime linkage researchers commonly use receiver operating characteristic (ROC) analysis to assess the accuracy of linkage decisions. Accuracy metrics derived from ROC analysis—such as the area under the curve (AUC)—offer certain advantages, but also have limitations. This paper describes the benefits that crime linkage researchers attribute to the AUC. We also discuss several limitations in crime linkage papers that rely on the AUC. We end by presenting suggestions for researchers who use ROC analysis to report on crime linkage. These suggestions aim to enhance the information presented to readers, derive more meaningful conclusions from analyses, and propose more informed recommendations for practitioners involved in crime linkage tasks. Our reflections may also benefit researchers from other areas of psychology who use ROC analysis in a wide range of prediction tasks.
Double‐Tuned RuCo Dual Metal Single Atoms and Nanoalloy with Synchronously Expedited Volmer/Tafel Kinetics for Effective and Ultrastable Ampere‐Level Current Density Hydrogen Production
Authors: Wang Xingkun , Yao Hanxu , Zhang Canhui , Li Cheng , Tong Kecheng , Gu Meng , Cao Zhengwen , Huang Minghua , Jiang Heqing 
Published: August 2023

AbstractAlkaline water electrolysis system is of general interest but is impeded by the unsatisfactory hydrogen evolution reaction (HER) performance under ampere‐level current density. Herein, the synchronous modification of complicated Volmer/Tafel kinetics is effectuated for attaining ampere‐level current density hydrogen production via engineering double‐tuned RuCo nanoalloy and dual metal single atoms on hierarchical N‐doped mesoporous carbon (RuCo@RuSACoSA‐NMC). The electronic structure of Ru sites in dual metal single atoms can be synergistically tailored by adjacent Co atomic sites and nanoalloy, which makes it achieve faster Volmer kinetics with rapid water adsorption/dissociation and transfer rates toward adsorbed hydroxyl. While double‐tuned Ru sites in nanoalloy by adjacent alloyed Co sites and dual metal single atoms undertake optimized Tafel kinetics with boosted transfer rates toward adsorbed hydrogen. Accordingly, RuCo@RuSACoSA‐NMC exhibits ultralow HER overpotential of 255 mV at 1 A cm−2 with robust stability over 24 days, ultrahigh mass activity of 37.2 A mgRu−1, and turnover frequency of 19.5 s−1. More importantly, RuCo@RuSACoSA‐NMC can make water electrolysis system possess low power consumption of 5.34 kWh per Nm3H2 and estimated costs of 1.197 $ per kgH2. The concept emphasized in this study provides guidance for rational design of cost‐effective catalysts with ampere‐level current density hydrogen production.
Growth Factor Immobilization to Synthetic Hydrogels: Bioactive bFGF‐Functionalized Polyisocyanide Hydrogels
Authors: van Velthoven Melissa J. J. , Gudde Aksel N. , Arendsen Evert , Roovers Jan‐Paul , Guler Zeliha , Oosterwijk Egbert , Kouwer Paul H. J. 
Published: August 2023

AbstractWith its involvement in cell proliferation, migration and differentiation basic fibroblast growth factor (bFGF) has great potential for tissue engineering purposes. So far, however, clinical translation of soluble bFGF‐based therapies is unsuccessful, because the required effective doses are often supraphysiological, which may cause adverse effects. An effective solution is growth factor immobilization, whereby bFGF retains its bioactivity at increased efficacy. Studied carriers include films, solid scaffolds, and particles, as well as natural and synthetic hydrogels. However, these synthetic hydrogels poorly resemble the characteristics of the native extracellular matrix (ECM). In this work, bFGF is covalently conjugated to the synthetic, but highly biocompatible, polyisocyanide‐based hydrogel (PIC‐bFGF), which closely mimics the architecture and mechanical properties of the ECM. The growth factor conjugation protocol is straightforward and readily extrapolated to other growth factors or proteins. The PIC‐bFGF hydrogel shows a prolonged bioactivity up to 4 weeks although no clear effects on the ECM metabolism are observed. Beyond the future potential of the PIC‐bFGF hydrogel toward various tissue engineering applications, this work underlines that simple biological conjugation procedures are a powerful strategy to induce additional bioactivity in 3D synthetic cell culture matrices.
Threshold Modulative Artificial GABAergic Nociceptor
Authors: Kim Geunyoung , Lee Younghyun , Jeon Jae Bum , Cheong Woon Hyung , Park Woojoon , Song Hanchan , Kim Kyung Min 
Published: August 2023

AbstractGamma‐aminobutyric acid (GABA) is a crucial inhibitory neurotransmitter of the central nervous system. It modifies the signal threshold of the nociceptor, allowing it to react to external stimuli in various circumstances. Thus, GABAergic behaviors are critical characteristics of adaptive behavior in life. Here, a threshold‐modulative artificial GABAergic nociceptor is reported for the first time at a Pt/Ti/Nb2O5−x/Al2O3−y/Pt/Ti (top to bottom) of the double charge trapping structure. The Al2O3−y layer contains deep defect states that function similarly to the GABA neurotransmitter in modulating the signal threshold. Meanwhile, the Nb2O5−x layer traps volatile charges and produces nociceptive behaviors. The combined dynamics of the two layers readily offer threshold‐modulative GABAergic nociceptive behaviors. Based on these GABAergic behaviors, a method of implementing hot‐ and cold‐sensitive thermoreceptors is demonstrated and shows its potential applications in advanced sensory devices.
Engineered Bio‐Heterojunction Confers Extra‐ and Intracellular Bacterial Ferroptosis and Hunger‐Triggered Cell Protection for Diabetic Wound Repair
Authors: Dai Wenyu , Shu Rui , Yang Fan , Li Bin , Johnson Hannah M. , Yu Sheng , Yang Hang , Chan Yau Kei , Yang Weizhong , Bai Ding , Deng Yi 
Published: August 2023

AbstractNanomaterial‐mediated ferroptosis has garnered considerable interest in the antibacterial field, as it invokes the disequilibrium of ion homeostasis and boosts lipid peroxidation in extra‐ and intracellular bacteria. However, current ferroptosis‐associated antibacterial strategies indiscriminately pose damage to healthy cells, ultimately compromising their biocompatibility. To address this daunting issue, this work has designed a precise ferroptosis bio‐heterojunction (F‐bio‐HJ) consisting of Fe2O3, Ti3C2‐MXene, and glucose oxidase (GOx) to induce extra‐intracellular bacteria‐targeted ferroptosis for infected diabetic cutaneous regeneration. Fe2O3/Ti3C2‐MXene@GOx (FMG) catalytically generates a considerable amount of ROS which assaults the membrane of extracellular bacteria, facilitating the permeation of synchronously generated Fe2+/Fe3+ into bacteria under near‐infrared (NIR) irradiation, causing planktonic bacterial death via ferroptosis, Fe2+ overload, and lipid peroxidation. Additionally, FMG facilitates intracellular bacterial ferroptosis by transporting Fe2+ into intracellular bacteria via inward ferroportin (FPN). With GOx consuming glucose, FMG creates hunger protection which helps macrophages escape cell ferroptosis by activating the adenosine 5’‐monophosphate (AMP) activated protein kinase (AMPK) pathway. In vivo results authenticate that FMG boosts diabetic infectious cutaneous regeneration without triggering ferroptosis in normal cells. As envisaged, the proposed tactic provides a promising approach to combat intractable infections by precisely terminating extra‐intracellular infection via steerable ferroptosis, thereby markedly elevating the biocompatibility of therapeutic ferroptosis‐mediated strategies.
Multivariate assessments of activity‐related skeletal changes: Interpreting Bell Beaker specialized male archery and social organization in Central Europe
Authors: Ryan‐Despraz J. , Villotte S. , Desideri J. , Besse M. 
Published: August 2023

AbstractObjectivesThe Bell Beaker period witnessed the rise of individual inhumations with “wealthy” burial contexts containing archery‐related grave goods, leading archaeologists to label the individuals in these tombs as “archers.” This study looks to (1) compare the skeletons from male “archer” burials with those from male “non‐archer” burials—those not having archery‐related grave goods—in order to assess a possible link between burial context and physical activity, and (2) apply a biomechanics profile to evaluate whether the individuals associated with these “archer” burials practiced specialized archer activity.Materials and MethodsThe corpus (males only) included 46 “archers” and 40 “non‐archers” from Bell Beaker individual inhumations. Osteological data included measurements, scores of entheseal changes, and a diagnosis of certain pathologies. Data analyses involved visual observations, hypothesis tests, dimension reduction, and MANOVA, with approaches aimed at exploring the treatment of data missingness.ResultsMeasurement data revealed no differences between the two groups. Evaluations of entheseal changes found that “non‐archers” had consistently more instances of bone surface modifications than “archers.” Individual assessments of specialized archer occupation identified 11 possible specialized archers.DiscussionThese findings indicate a possible labor differentiation represented through the presence of a probably prestigious “archer” burial context. This suggests a link between grave good presence and labor, but not between a Bell Beaker archery occupation and an “archer” burial context. Data analyses support the application of biomechanics to osteological analyses in order to assess specialized activity on the skeleton.
Semiconducting Polymers Based on Simple Electron‐Deficient Cyanated trans‐1,3‐Butadienes for Organic Field‐Effect Transistors
Authors: Li Jianfeng , Chen Zhicai , Wang Junwei , Young Jeong Sang , Yang Kun , Feng Kui , Yang Jie , Liu Bin , Woo Han Young , Guo Xugang 
Published: August 2023

AbstractDeveloping high‐performance but low‐cost n‐type polymers remains a significant challenge in the commercialization of organic field‐effect transistors (OFETs). To achieve this objective, it is essential to design the key electron‐deficient units with simple structures and facile preparation processes, which can facilitate the production of low‐cost n‐type polymers. Herein, by sequentially introducing fluorine and cyano functionalities onto trans‐1,3‐butadiene, we developed a series of structurally simple but highly electron‐deficient building blocks, namely 1,4‐dicyano‐butadiene (CNDE), 3‐fluoro‐1,4‐dicyano‐butadiene (CNFDE), and 2,3‐difluoro‐1,4‐dicyano‐butadiene (CNDFDE), featuring a highly coplanar backbone and deep‐positioned lowest unoccupied molecular orbital (LUMO) energy levels (−3.03–4.33 eV), which render them highly attractive for developing n‐type semiconducting polymers. Notably, all these electron‐deficient units can be easily accessed by a two‐step high‐yield synthetic procedure from low‐cost raw materials, thus rendering them highly promising candidates for commercial applications. Upon polymerization with diketopyrrolopyrrole (DPP), three copolymers were developed that demonstrated unipolar n‐type transport characteristics in OFETs with the highest electron mobility of >1 cm2 V−1 s−1. Hence, CNDE, CNFDE, and CNDFDE represent a class of novel, simple, and efficient electron‐deficient units for constructing low‐cost n‐type polymers, thereby providing valuable insight for OFET applications.
Input‐based event‐triggered control of a discrete‐time singularly perturbed system under a resource constrained environment
Authors: Sahu Poonam , Bhandari Manisha , Fulwani Deepak 
Published: August 2023

AbstractThis paper proposes an input‐based event‐triggered mechanism for a network‐controlled discrete‐time singularly perturbed system, where the latest measurements are transmitted when a predefined condition is satisfied on the input. The significant contribution of the proposed work is the separation of control updates for slow and fast dynamics such that the proposed event‐triggered mechanism updates and broadcasts the current measurements of slow and fast dynamics in their respective time scales and reduces the usage of network resources. Further, the proposed input‐based event‐triggered mechanism avoids redundant updates of the control input and reduces actuation and resource utilization in some instances. Furthermore, the ultimate boundedness of the system states is established. The simulation uses a quarter‐car suspension system to demonstrate the proposed theory.
Linkage of whole genome sequencing and administrative health data in autism: A proof of concept study
Authors: Baribeau Danielle A. , Arneja Jasleen , Wang Xuesong , Howe Jennifer , McLaughlin John R. , Tu Karen , Guan Jun , Iaboni Alana , Kelley Elizabeth , Ayub Muhammad , Nicolson Robert , Georgiades Stelios , Scherer Stephen W. , Bronskill Susan E. , Anagnostou Evdokia , Brooks Jennifer D. 
Published: August 2023

AbstractWhether genetic testing in autism can help understand longitudinal health outcomes and health service needs is unclear. The objective of this study was to determine whether carrying an autism‐associated rare genetic variant is associated with differences in health system utilization by autistic children and youth. This retrospective cohort study examined 415 autistic children/youth who underwent genome sequencing and data collection through a translational neuroscience program (Province of Ontario Neurodevelopmental Disorders Network). Participant data were linked to provincial health administrative databases to identify historical health service utilization, health care costs, and complex chronic medical conditions during a 3‐year period. Health administrative data were compared between participants with and without a rare genetic variant in at least 1 of 74 genes associated with autism. Participants with a rare variant impacting an autism‐associated gene (n = 83, 20%) were less likely to have received psychiatric care (at least one psychiatrist visit: 19.3% vs. 34.3%, p = 0.01; outpatient mental health visit: 66% vs. 77%, p = 0.04). Health care costs were similar between groups (median: $5589 vs. $4938, p = 0.4) and genetic status was not associated with odds of being a high‐cost participant (top 20%) in this cohort. There were no differences in the proportion with complex chronic medical conditions between those with and without an autism‐associated genetic variant. Our study highlights the feasibility and potential value of genomic and health system data linkage to understand health service needs, disparities, and health trajectories in individuals with neurodevelopmental conditions.
Self‐micellizing solid dispersion of tacrolimus: Physicochemical and pharmacokinetic characterization
Authors: Makino Keisuke , Tsukada Ryota , Kambayashi Atsushi , Yamada Kohei , Sato Hideyuki , Onoue Satomi 
Published: August 2023

AbstractThe present study was undertaken to develop a self‐micellizing solid dispersion (SMSD) of tacrolimus (TAC) to improve the biopharmaceutical properties of TAC. An SMSD formulation of TAC (SMSD/TAC) and amorphous solid dispersion formulation of TAC (ASD/TAC) were prepared with Soluplus®, an amphiphilic copolymer, and hydroxypropyl cellulose, respectively. Physicochemical properties were characterized in terms of morphology, crystallinity, storage stability, interaction of TAC with Soluplus®, and micelle‐forming potency; pharmacokinetic behavior was also evaluated in rats. Tacrolimus in both formulations was in an amorphous state. After storage at 40°C/75% relativity humidity for 4 weeks, there were no significant changes in the crystallinity of TAC between nonaged and aged SMSD/TAC, whereas slight recrystallization was observed in aged ASD/TAC. The results of circular dichroism (CD) and infrared spectroscopic analyses were indicative of the potent drug–polymer interaction in SMSD/TAC, possibly leading to the prevention of recrystallization. Compared with other TAC samples, SMSD/TAC exhibited significant improvement in the dissolution behavior of TAC through the immediate formation of fine micelles. After the oral administration of TAC samples (10 mg TAC/kg) to rats, there was marked enhancement in systemic exposure to TAC with both formulations; in particular, SMSD/TAC achieved an increase in bioavailability ca. 20‐fold higher than crystalline TAC. The SMSD approach might provide an effective dosage form for TAC with enhanced physicochemical stability and oral absorption.
Intracellular accumulation of c‐di‐GMP and its regulation on self‐flocculation of the bacterial cells of Zymomonas mobilis
Authors: Li Kai , Xia Juan , Liu Chen‐Guang , Zhao Xin‐Qing , Bai Feng‐Wu 
Published: August 2023

AbstractZymomonas mobilis is an emerging chassis for being engineered to produce bulk products due to its unique glycolysis through the Entner–Doudoroff pathway with less ATP produced for lower biomass accumulation and higher product yield. When self‐flocculated, the bacterial cells are more productive, since they can self‐immobilize within bioreactors for high density, and are more tolerant to stresses for higher product titers, but this morphology needs to be controlled properly to avoid internal mass transfer limitation associated with their strong self‐flocculation. Herewith we explored the regulation of cyclic diguanosine monophosphate (c‐di‐GMP) on self‐flocculation of the bacterial cells through activating cellulose biosynthesis. While ZMO1365 and ZMO0919 with GGDEF domains for diguanylate cyclase activity catalyze c‐di‐GMP biosynthesis, ZMO1487 with an EAL domain for phosphodiesterase activity catalyzes c‐di‐GMP degradation, but ZMO1055 and ZMO0401 contain the dual domains with phosphodiesterase activity predominated. Since c‐di‐GMP is synthesized from GTP, the intracellular accumulation of this signal molecule through deactivating phosphodiesterase activity is preferred for activating cellulose biosynthesis to flocculate the bacterial cells, because such a strategy exerts less perturbance on intracellular processes regulated by GTP. These discoveries are significant for not only engineering unicellular Z. mobilis strains with the self‐flocculating morphology to boost production but also understanding mechanism underlying c‐di‐GMP biosynthesis and degradation in the bacterium.
Synthesis and adsorption properties of H4Ti5O12@CNT ion sieves
Authors: Gao Yuyu , Chen Jin , Chu Suihong , Yang Bo , Zheng Lu , Liu Min 
Published: August 2023

AbstractIn this study, H4Ti5O12@CNT ion sieves with an encapsulated structure were fabricated by combining pretreated carbon nanotubes (CNTs) as a template and carbon source, C16H36O4Ti as a titanium source, and CH3COOLi as a lithium source. By characterizing and analyzing the pretreated and untreated CNTs, numerous COOH and OH functional groups were introduced into the pretreated CNTs, which improved their dispersion in aqueous solutions and ethanol and facilitated the adsorption of lithium ions. The ion sieves prepared with the precursor roasted at 700 °C showed the best adsorption performance. Moreover, the structural integrity of the ion sieves was not affected by acid washing. For the first adsorption cycle, the ion sieves had a lithium‐ion saturated adsorption capacity of 32.32 mg/g. After five adsorption–desorption cycles, the adsorption capacity only decreased by 5.1% to 30.68 mg/g, which shows that they had good cycling stability.
Influence of financial resources on sustainability performance of SMEs in emerging economy: The role of managerial and firm level attributes
Authors: Khattak Muhammad Sualeh , Wu Qiang , Ahmad Maqsood 
Published: August 2023

AbstractThis research investigates whether managerial level attributes (age, education, and experience) and firm level attributes (size and age) influence the role of financial resources (FR) on sustainability performance in small and medium enterprises (SMEs) in emerging economies. To test the model, the analyses were performed through SmartPLS based on 611 Pakistani SMEs. The results of the structural equation modeling indicate that the positive relationship between FR and sustainability performance is significantly strengthened by managerial attributes (manager experience and education) and firm level attributes (firm size). However, manager age and firm age do not moderate the nexus between FR and sustainability performance. This research recommends SMEs to focus on experienced and educated managers as compared to older ones to utilize their FR efficiently in sustainable activities. This research enriches the resource base view and upper echelon literature through empirical evidence. Further implications for policymakers and businesses are discussed.
Focus on evidence‐based anatomy in contemporary anatomy education: Arguments in favor of a pragmatic approach
Authors: Ghosh Sanjib Kumar 
Published: August 2023

AbstractThe concept of evidence‐based anatomy (EBA) emerged in 2014 and has become a significant element in contemporary anatomy education. The evolving fabric of the medical education curriculum has necessitated critical changes in practice. EBA enables these changes to be incorporated seamlessly and implemented congruently into anatomy education programs. However, in parallel, non‐evidence‐based (classical) knowledge that has been built up through centuries of anatomical practice continues to be the core element of anatomy education in some countries/regions. Its inherent limitations hinder integration with clinical practice, leading to a rise in misadventures in the clinical setting. This viewpoint commentary highlights the strengths of EBA vis‐à‐vis the related attributes of classical anatomy. Appropriate arguments show that EBA helps to reduce cognitive load and enables knowledge to be delivered through innovative education tools. EBA also helps to create an inclusive learning environment in a technology‐driven era. Moreover, empowered by robust resources, it is driving the pertinent amalgamation of anatomy knowledge with clinical practice. This viewpoint article endorses the adoption of EBA in contemporary anatomy education on the basis of its potential for shaping future anatomical practice.