bluuebunny/crossref_metadata_2025_split huggingface dataset:
Navigating the Challenges of Minimally Invasive Mitral Valve Surgery: A Risk Analysis and Learning Curve Evaluation
Authors: Papadopoulos Nestoras , Ntinopoulos Vasileios , Dushaj Stak , Häussler Achim , Odavic Dragan , Biefer Hector Rodríguez Cetina , Dzemali Omer 
Published: July 2023

Abstract
Background This study aimed to report on the risk analysis and learning curve analysis of a minimally invasive mitral valve surgery program performed through a right mini-thoracotomy at a single institution.Methods From January 2013 through December 2019, we retrospectively reviewed 266 patients who underwent minimally invasive mitral valve surgery. Multiple logistic regression analysis was used for the adverse event outcome. Distribution over time of perioperative complications, defined as clinical endpoints in the Valve Academic Research Consortium-2 (VARC-2) consensus document, as well as CUSUM charts for assessment of cardiopulmonary bypass and aortic cross-clamping duration over time, has been performed for learning curve assessment.Results Overall incidences of postoperative stroke (1.1%), myocardial infarction (1.1%), and thirty-day mortality (1.5%) were low. The mitral valve reconstruction rate in our series counted 95%. Multivariable analysis revealed that concomitant tricuspid valve surgery (OR:4.44;95%CI:1.61–11.80;p = 0.003) was significantly associated with adverse event outcomes. Despite a trend towards adverse event outcomes in patients with preexisting active mitral valve endocarditis (OR:2.69;95%CI:0.81–7.87;p = 0.082), mitral valve pathology did not significantly impact postoperative morbidity and mortality. Distribution over time of perioperative complications, defined as clinical endpoints in the VARC-2 consensus document, showed a trend towards an improved complication rate after the initial 65 to 100 procedures.Conclusions Mitral valve surgery via right-sided mini-thoracotomy can be implemented safely with low perioperative morbidity and mortality rates. Careful patient selection regarding isolated mitral valve surgery in the presence of degenerative mitral valve disease may represent a significant safety issue during the learning curve.Trial Registration The cantonal ethics commission of Zurich approved the study (registration ID 2020 − 00752, date of approval 24 April 2020).
Protocol for a feasibility trial (EXPRESS-C-GVHD) for an expressive helping intervention within a support group for cutaneous graft-versus-host-disease
Authors: Kaundinya Trisha , Kye Yae , El-Behaedi Salma E. , Choi Jennifer N. 
Published: July 2023

Abstract
Background
Cutaneous graft-versus-host disease (cuGVHD) is a complication of allogeneic hematopoietic stem cell transplantation that presents with varying severity and can significantly affect one’s quality of life (QOL). No trials have yet tested nonpharmacologic interventions to improve the QOL of patients with cuGVHD. The primary objective of the Expressive Helping in Support Groups for Cutaneous GVHD (EXPRESS-C-GVHD) Trial is to evaluate the effect of a support group that employs expressive writing on cutaneous and systemic GVHD symptoms, general distress, and QOL immediately after the intervention. Secondary objectives include evaluating the impact of the intervention on QOL at 1 month post intervention, as well as willingness to participate, compliance, feasibility, and satisfaction.
Methods
The EXPRESS-C-GVHD Trial will include patients with chronic cuGVHD who are at least 18 years old and able to use a writing utensil, have access to Zoom, an online video conference platform, and attend all four live support group sessions. Subjects will be recruited from the Department of Dermatology, Northwestern University, Chicago, IL and will participate in a 4-week program via Zoom. Program activities will be 1 hour long and consist of 40 minutes of participant-led verbal reflection and discussion in a group setting in response to prompts, and 20 minutes of expressive writing. Participants will fill out a baseline willingness survey, follow-up surveys after every session, and post-intervention surveys at 2 weeks and 1 month after intervention.
Discussion
The EXPRESS-C-GVHD Trial is a pilot trial and will assess whether a Zoom-based expressive writing intervention within the framework of a support group is feasible and can improve QOL outcomes among individuals with cuGVHD.
Trial Registration
The trial is registered under number NCT05694832
Functional physical training improves fitness and cognitive development in 4~5 years old children
Authors: Hao Lei , Fan Yongzhao , Zhang Xiaojuan , Rong Xiangjiang , Sun Youping , Liu Kun 
Published: July 2023

Abstract
Development of physical and cognitive function is very critical in 4–5 years children. It has been addressed in this research if the specific functional training with or without cognitive training can be effective on improving fitness and cognitive development in 4–5 years preschool children. A total of 126 preschool children in the 4–5 age range were selected as participants and randomly assigned to one of four groups: the control group (C), the physical function training group (P), the cognitive training group (CT), and the physical function training combined with cognitive training group (PCT). The results revealed significant pre/post differences in body height and weight among all four groups of children. Furthermore, there was no significant difference in physical fitness between the C group and the CT group after the intervention. However, the children in the P group and the PCT group showed significant improvements in three indicators including standing long jump, continuous jump, and 10-meter shuttle running. Additionally, the children in P group, CT group, and the PCT group demonstrated significant improvement in simple reaction time, attention, and spatial memory. No significant cognitive improvement was found in C group. Functional physical training with or without cognitive intervention can promote both physical fitness and cognitive development in children aged 4–5 years. Cognitive training alone can significantly improve cognitive function but not physical. Therefore, functional physical training can be used alone to improve the physical and cognitive abilities for aged 4–5 years old children.
Mixed cell adenocarcinoma of the endometrium: a population-based study
Authors: Lu Hongdi , Wang Junfeng , Wei Huafang , Han Dan , Wang Sheng 
Published: July 2023

Abstract

Background Mixed cell adenocarcinoma of endometrium (MCAE) is a rare histological subtype of endometrial carcinoma. However, there are limited studies investigating the prognostic factors of MCAE. Therefore, the present study aimed to explore the independent predictors of MCEA and build a prognostic nomogram for the overall survival (OS) of MCAE patients. Methods Data on MCAE patients were screened from the Surveillance, Epidemiology, and End Results (SEER) database. The MCAE prognosis in patients with Federation of Gynecology and Obstetrics (FIGO) stage I/II and stage III/IV was explored. Next, the patients in stage I/II and stage III/IV were assigned into training and validation cohorts in the ratio of 7:3, respectively. Univariate and multivariate Cox regression was used to determine the independent risk factors for the OS, and nomograms were constructed based on these factors. The concordance index (C-index) and calibration plots were established to assess the discrimination ability and accuracy of the nomograms. Finally, the decision curve analysis (DCA), net reclassification index (NRI), and integrated discrimination improvement (IDI) were calculated to compare performance between the nomogram and the traditional FIGO stage model. Results A total of 6650 patients were enrolled in our study, among which 4635 patients were in stage I/II and 2015 in stage III/IV. Age, marital status, race, FIGO stage, and surgery were identified as the independent predictors for patients in FIGO stage I/II, while age, marital status, race, FIGO stage, surgery, radiation, and chemotherapy for patients in stage III/IV (p < 0.05). NomogramA for stage I/II and nomogramB for stage III/IV were constructed based on the independent predictors. The C-indexes in nomogramA were 0.730 (95%CI: 0.711 ~ 0.749) and 0.715 (95%CI: 0.685 ~ 0.745) for the training and validation cohorts, and 0.720 (95%CI: 0.702 ~ 0.738) and 0.724 (95%CI: 0.697 ~ 0.751) in nomogramB, respectively. Calibration curves for both nomograms followed the diagonal line, implying an excellent consistency between the predicted and actual survival. In addition, the DCA revealed that nomograms had a higher clinical benefit compared to the FIGO stages. In stage I/II patients, the NRI and IDI for 3, 5, and 10 years were more than 30% and 10%, respectively (p < 0.001). In stage III/IV patients, the NRI and IDI values were more than 20% and 6%, respectively (p < 0.001). Both NRI and IDI values were further tested in the validation cohort. Overall, the predictive performance of nomogramA and nomogramB was higher compared to the traditional FIGO stage model. Conclusions The predictive nomograms for MCAE patients in FIGO stage I/II and stage III/IV constructed and validated in this study could offer an effective tool for evaluating the treatment outcome in MCAE patients.
Breastfeeding of Indigenous Infants From a Small Rural Cohort in Australia
Authors: Onifade Oyepeju , Schumacher Tracy , Rae Kym , Pringle Kirsty , Committee Gomeroi Gaaynggal Advisory 
Published: July 2023

Abstract
Background
Exclusive breastfeeding is recommended during an infant’s first six months of life as it adequately meets the nutritional needs of the infant. The aim of this study was to describe the intention to breastfeed, and breastfeeding trends of Indigenous participants in the Gomeroi Gaaynggal cohort.
Methods
The Gomeroi Gaaynggal study was a longitudinal cohort of Indigenous mother-child dyads. Mothers were recruited to the study by Indigenous research assistants. Mother’s intention to breastfeed and previous breastfeeding history were obtained from hospital antenatal records. Infant breastfeeding details were obtained at approximately 3-, 6-, 9-,12- and 24-month visits. Data were analysed descriptively.
Results
Obstetric details were obtained from a total of 250 mothers. Breastfeeding data were available for 133 infants and provided 302 entries between 3- and 24-months of age. Most of the mothers (72%) indicated an intention to breastfeed their infants exclusively after delivery. Approximately 84% of infants received some form of breastfeeding. Half of the infants (50%) ceased breastfeeding by approximately 50 days. Only 15% of mothers reported having trouble with breastfeeding.
Conclusion
Findings from this study are consistent with breastfeeding trends among other Australian populations. Further investigations are required to identify factors contributing to the short breastfeeding duration observed in this cohort.
Numerical Solution for nonlinear Volterra-Fredholm Integro-Differential Equations using Adomian and Modified Adomian Decomposition Method
Authors: Ansari Asiya , Ahmad Najmuddin 
Published: July 2023

Abstract
In this article, the Adomian Decomposition Method (ADM) and Modified Adomian Decomposition Method (MADM) are introduced to provide the approximate solutions for Volterra-Fredholm Integro-differential equations. Moreover, we prove the existence and uniqueness results and convergence of the solutions. To arrive at that conclusion, an algorithm is used. Additionally, examples of deterministic models in graphs and tables are used to perform the convergence analysis of the proposed technique.
GNF-7, a novel FLT3 inhibitor, overcomes drug resistance for the treatment of FLT3‑ITD acute myeloid leukemia
Authors: Xiao Xinhua , Wang Peihong , Zhang Weina , Wang Jiayi , Cai Mansi , Jiang Hua , Wu Yingli , Shan Huizhuang 
Published: July 2023

Abstract
Background
Acute myeloid leukemia (AML) with FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation accounts for a large proportion of AML patients and diagnosed with dismay prognosis. Although the prognosis of FLT3-ITD AML has been greatly improved, the drug resistance frequently occurred in the treatment of FLT3 target drugs. GNF-7, a multitargeted kinase inhibitor, which provided a novel therapeutic strategy for overriding leukemia. In this study, we explored the antitumor activity of GNF-7 against FLT3-ITD and clinically-relevant drug resistance in FLT3 mutant AML.
Methods
Growth inhibitory assays were performed in AML cell lines and Ba/F3 cells expressing various FLT3 mutants to evaluate the antitumor activity of GNF-7 in vitro. Western blotting was used to examine the activity of FLT3 and its downstream pathways. Molecular docking was performed to predict the binding sites of FLT3 to GNF-7. The survival benefit of GNF-7 in vivo was assessed in mouse models of transformed Ba/F3 cells harboring FLT3-ITD and FLT3-ITD/F691L mutation. Primary patient samples and a patient-derived xenograft (PDX) model were also used to determine the efficacy of GNF-7.
Results
GNF-7 inhibited the cell proliferation of Ba/F3 cells expressing FLT3-ITD and exhibited potently anti-leukemia activity on primary FLT3-ITD AML samples. Moreover, GNF-7 could bind to FLT3 protein and inhibit the phosphorylation of downstream effectors in the FLT3 signaling pathways. In vitro and in vivo studies showed that GNF-7 exhibited a potent inhibitory activity against FLT3-ITD/F691L that confers resistant to quizartinib (AC220) or gilteritinib. Importantly, GNF-7 showed potent cytotoxic effect on leukemic stem cells, significantly extend the survival of PDX model and exhibited similar therapy effect compared with gilteritinib.
Conclusions
Our results show that GNF-7 is a potent FLT3-ITD inhibitor and may become a promising lead compound applied for treating some of the clinically drug resistant patients.
Cell-surface photochemistry mediated calcium overload for synergistic tumor therapy
Authors: Wang Jun , Wang Wei , Shen Qingmei , Lan Lan , Guan Cuiping , Xu Xinchang , Li Weishuo , Du Yongzhong 
Published: July 2023

Abstract
Calcium (Ca2+) is essential for mitochondrial homeostasis and function coordination, particularly in cancer cells that metabolize frequently to sustain their growth. Photochemistry mediated calcium overload has attracted lots of attention as an effective way to achieve tumor suppression. Herein, we developed a cell-surface photochemistry to synergistically induce calcium overload and thus tumor suppression. Specially, we synthesized a polymer bearing photo-crosslinking cinnamate groups (CA) and anti-CD20 aptamers (Apt), which was further introduced onto upconversion nanoparticles (UCNP) (AH(CA)@UCNP). Then the photosensitizer, Protoporphyrin IX (PpIX) was loaded onto AH(CA)@UCNP to give AH(CA)@UCNP-PpIX. The interaction between CD20 receptors and anti-CD20 aptamers allowed AH(CA)@UCNP-PpIX to accurately attach onto the Raji cell surface after an intravenous injection. Following the local application of a 980 nm NIR laser, the UCNP moiety was able to capture the NIR light and convert it into ultraviolet (UV) light, resulting in the crosslinking of CA, further stimulating the clustering of CD20 receptors and causing Ca2+ influx. Additionally, the UV light could simultaneously excited PpIX to generate reactive oxygen species (ROS) in situ to break down the integrity of cell membrane and lead to an influx of Ca2+. The photochemistry-mediated Ca2+ overload mediated by AH(CA)@UCNP-PpIX exhibited a synergistic and superior anti-tumor efficacy. We believe this photochemistry expands the toolbox to manipulate intracellular Ca2+ concentration and holds a great potential as an anti-tumor therapy.
The relationships between novel biomarkers Lp-PLA2 and CTRP-3 and MACCE in patients with type 2 diabetes mellitus aged 40-65 years in a population-based study
Authors: Chen Yanhong , Wang Shixin , Li Jian , Fu Yu , Chen Pengsheng , Zhang Jiao , Sun Li , Zhang Rui , Li Xiaoli , Liu Lingling 
Published: July 2023

Abstract
Background
Adverse cardiovascular and cerebrovascular events (MACCE, mainly includes: cardiovascular or cerebrovascular death, acute coronary syndrome, coronary stent implantation, and stroke) has been confirmed as one of the major and severe complications in type 2 diabetes mellitus (T2DM) patients aged 40–65 years, and it is also reported as one of the major causes of death in T2DM patients. Accordingly, the biological markers of MACCE in T2DM patients aged 40–65 years should be found urgently.
Methods
The retrospective cohort study comprised 979 individuals of T2DM aged 40–65 years. To be specific, 116 subjects developed MACCE during the follow-up. The clinical examination and the measurement of blood laboratory parameters were performed. Age- and sex-adjusted Cox regression analysis were adopted to analyze the correlation between lipoprotein associated phospholipase (Lp-PLA2), C1q/tumor necrosis factorsassociated protein 3 (CTRP-3) and MACCE in T2DM patients aged 40–65 years. The diagnostic efficacy of the respective index was analyzed using the receiver operating characteristic (ROC) curve and the area under curve (AUC).
Results
After a median 84 months follow-up [42, (32–54)], the levels of new inflammatory factors Lp-PLA2, CTRP-3 and other traditional indices of blood lipids such as HDL-C, LDL-C and ApoB were abnormally expressed in MACCE patients of the positive group of T2DM patients aged 40–65 years. Age- and sex-adjusted Cox regression analysis showed that Lp-PLA2 (HR = 1.007, 95% confidence interval (CI): 1.005–1.009, P < 0.001) and CTRP-3 (HR = 0.943, 95% CI: 0.935–0.954, P < 0.001) were independently correlated with the occurrence of MACCE. The receiver operating characteristic (ROC) curve analysis showed that Lp-PLA2 and CTRP-3 could strongly predict the occurrence of MACCE (area under ROC (AUC) = 0.81, 95% CI: 0.77–0.85, P < 0.001) (AUC = 0.91, 95% CI: 0.89–0.93, P < 0.001). Combined Lp-PLA2 with CTRP-3 can predict the occurrence of MACCE well (AUC = 0.94, 95% CI: 0.93–0.96, P < 0.001).
Conclusions
The serum levels of Lp-PLA2 and CTRP-3 were abnormally expressed in MACCE patients of T2DM patients aged 40–65 years, and both of them were correlated with the occurrence of MACCE. The combined detection of Lp-PLA2 and CTRP-3 could improve the diagnostic efficacy of MACCE in T2DM patients aged 40–65 years.
Structural, thermoelectric, elastic, and electronic properties of XPdH3 (X = Li, Na, K) for hydrogen storage application: A first principle study
Authors: Shakoor Saba Abdul , Murtazaa Gulam , Raza Hafiz Hamid , Ahmad Nazir , Rehman Senia Abdur 
Published: July 2023

Abstract
Hydrogen storage is captivating to research interest as it has renewable, green, and clean energy properties. Therefore, continual research has been conducted to find suitable and innovative compounds that can fulfill the criteria of H2 storage. First-principles study of XPdH3 (X=Li, Na, K) compounds are conducted to examine their properties by using the full potential-linearized augmented-plane-wave (FP-LAPW) method installed in the WIEN2K code. Numerous properties of these hydrides such as electronic, structural, thermoelectric, and elastic have been studied. XPdH3 (X = Li, Na, K) compounds have Pm3m (221) space group and cubic crystal structures. The electronic properties of XPdH3 (X = Li, Na, K) compounds are metallic. All three hydrides are stable and satisfied Born stability criteria. The gravimetric H2 storage capacities of these compounds are 2.598, 2.2381, and 2.0355 wt % respectively. Moreover, the thermal properties of XPdH3 (X=Li, Na, K) are also discussed using Boltztrap software.
Alternative Approach for Deriving an Unconventional Distance Protection Algorithm
Authors: Araújo Marcos R. , Batista Edson A. 
Published: July 2023

Abstract

This work presents an alternative approach for deriving an unconventional distance protection algorithm suitable for long single-circuit transmission lines. Such approach is based on the application of Kirchhoff's Laws to a system modeled in the frequency domain. The electric power system considered and the steps of the protection algorithm deduction approach are detailed. As a result, the same input signals from the literature are obtained, which demonstrates the suitability of the methodology adopted to the modeled system. Thus, the extensiveness of such approach makes it a viable alternative for the deduction of new protection algorithms in electrical power systems with different configurations.
The Inadequate Oxygen Delivery Index and its Correlation with Venous Saturation in the Pediatric Cardiac Intensive Care Unit
Authors: Loomba Rohit S. , Villarreal Enrique G. , Flores Saul , Farias Juan S. , Constas Alex 
Published: July 2023

Abstract
Background
Continuous monitoring software, T3, has an integrated index called the inadequate oxygen delivery index 50% (IDO2-50%) which displays a probability that the mixed venous saturation is below a user-selected threshold of 30–50%. The primary aim of this study was to determine the correlation of the IDO2-50% with a measured venous saturation. The secondary aim of this study was to characterize the hemodynamic factors that contributed to the IDO2-50%.
Methods
This single-center, retrospective study aimed to characterize the correlation between IDO2-50% and inferior vena cava (IVC) saturation. A Bayesian Pearson correlation was conducted to assess the correlation between the collected variables of interest, with a particular interest in the correlation between the IDO2-50% and the IVC saturation. Receiver operator curve (ROC) analysis to assess the ability of the IDO2-50% to identify when the venous saturation was less than 50%. Bayesian linear regression was done with the IDO2-50% (dependent variable) and other independent variables.
Results
A total of 113 datasets were collected across 15 unique patients. IDO2-50% and the IVC saturation had moderate correlation with the IVC saturation (correlation coefficient − 0.569). The IDO2-50% had a weak but significant correlation with cerebral near infrared spectroscopy (NIRS) values, a weak but significant correlation with heart rate, and a moderate and significant correlation with arterial saturation. ROC analysis demonstrated that the IDO2-50% had a good ability to identify a venous saturation below 50%, with an area under the curve of 0.797, cutoff point of 24.5 with a sensitivity of 81%, specificity of 66%, positive predictive value of 44% and negative predictive value of 91%. Bayesian linear regression analysis yielded the following model: 237.82 + (1.18 x age in months) – (3.31 x arterial saturation) – (1.92 x cerebral NIRS) + (0.84 x heart rate).
Conclusion
The IDO2 index has moderate correlation with IVC saturation. It has good sensitive and negative predictive value. Cerebral NIRS does appear to correlate better with the underlying venous saturation than the IDO2 index.