bluuebunny/crossref_metadata_2025_split huggingface dataset:
Working with the EU: How Discourses Shape the Application of EU State Aid Rules
Authors: Steunenberg Bernard , Zwaan Pieter 
Published: April 2023

AbstractState aid rules are an important part of the European Union's (EU) competition policy that aims to ensure a fair competition in the common market. These rules directly affect national and sub‐national governments of member states, which are sometimes confronted with different and opposing claims about what to do. The question is how implementing civil servants interpret and resolve these claims in practice. In this article, discourse analysis is applied to identify how civil servants apply and interpret state aid rules based on empirical research in the Netherlands. The main finding is that, even within the existing regulatory framework of one member state, the application of state aid rules is understood differently based on the discourses we identified. We describe the content, dissemination amongst civil servants and the relationship of these discourses with compliance. The article shows that discourses matter and help to understand how state aid rules are applied.
The importance and challenges of improving early identification of language abilities: a commentary on Gasparini et al. (2023)
Authors: Botting Nicola , Spicer‐Cain Helen 
Published: April 2023

Finding early predictors of later language skills and difficulties is fraught with challenges because of the wide developmental variation in language. Gasparini et al. (Journal of Child Psychology and Psychiatry, 2023) aimed to address this issue by applying machine learning methods to parent reports taken from a large longitudinal database (Early Language in Victoria Study). Using this approach, they identify two short, straightforward item sets, taken at 24 and 36 months, that can adequately predict language difficulties when children are 11 years of age. Their work represents an exciting step towards earlier recognition and support for children with Developmental Language Disorder. This commentary highlights the advantages and challenges of identifying early predictors of language in this way, and discusses future directions that can build on this important contribution.
Clin‐STAR corner: 2021 update in musculoskeletal pain in older adults with a focus on osteoarthritis‐related pain
Authors: Adogwa Owoicho , Reid M. Cary , Chilakapati Sai , Makris Una E. 
Published: April 2023

AbstractChronic musculoskeletal (MSK) pain remains a leading cause of disability and functional impairment among older adults and is associated with substantial societal and personal costs. Chronic pain is particularly challenging to manage in older adults because of multimorbidity, concerns about treatment‐related harm, as well as older adults' beliefs about pain and its management. This narrative review presents data on nine high‐quality, peer‐reviewed clinical trials published primarily over the past two years that focus on MSK pain management in older adults, of which four were comprehensively reviewed. These studies address contributors to knee osteoarthritis (OA) pain (insomnia), provide evidence for digital delivery or artificial intelligence driven behavioral interventions and potentially more efficient/equally effective modes of delivering glucocorticoids for OA; each of the selected studies have potential for scalability and meaningful impact in the care of older adults.
Confronting the deep problem of consumption: Why individual responsibility for mindful consumption matters
Authors: Parvatiyar Atul , Sheth Jagdish N. 
Published: April 2023

AbstractDecades of intentional cultivation of consumerism, materialism, affluence, and hedonism, fueled by advertising messages, have created a consumption culture that is not sustainable anymore. In addition to the problems of climate change, there are also significant social costs associated with overconsumption and harmful consumption. We identify the causes of the consumption problem and why individual consumers must take responsibility to avoid harmful consumption for their own and societal well‐being. Although multi‐faceted action by governments, marketers, and civil societies is essential, a bottom‐up transformational movement is also required to drive the mindful consumption mindset. Top‐down measures of technology‐led efficient product solutions and consumer nudging strategies have had limited success compared to the rate at which the problem is compounding. Thus, we suggest four critical interventions to socialize the bottom‐up mindful consumption movement—education for transformative social learning; alternative hedonism; advertising, tv, and social media messaging; and creating an engagement forum for all like‐minded people devoted to the cause. Through socializing the bottom‐up mindful consumption movement, these interventions will encourage a cultural shift toward alternative lifestyle conceptions of well‐being, leading to increased sustainable consumption behavior and eudaimonia.
Psychological distancing and language intensity in Peer‐to‐Peer lending
Authors: Huang Jin , Li Jun , Sena Vania 
Published: April 2023

AbstractPeer‐to‐peer (P2P) lending is referred to as lending money to unknown borrowers directly through online platforms without using traditional financial intermediaries. We leverage insights from the literature on psychological distancing and affective intensity to argue that linguistic styles, as the manifestation of social psychological distance, have a negative impact on P2P funding success. Testing our arguments with data from a major Chinese P2P platform, we find that using too many “you” and negations (proxies for social psychological distance) in the borrower's description will dampen a lender's willingness to support a funding campaign. Moreover, when the social psychological distance is large, language intensity can be perceived as desperate, making a lender even less willing to support the funding campaign. Our research shed new light on the role of language in P2P funding success and has practical implications for lenders, borrowers and regulators in overcoming barriers in P2P lending.
Digital beading for a CAD–CAM framework for an implant‐supported overdenture: A dental technique
Authors: Altoman Majed S. , Gadah Thuraya S. , Alfaifi Mohammed A. , Kattadiyil Mathew T. 
Published: April 2023

AbstractThe analog technique of making bead lines for a metal superstructure framework for the maxillary implant‐supported overdenture is created by scribing shallow grooves on the surface of a definitive gypsum cast. This report describes a digital technique that uses computer‐aided design and computer‐aided manufacturing technology to make dental bead lines on an intraoral impression without using the gypsum cast.
Serum proteome of dogs with chronic enteropathy
Authors: Yu Jane , Ruaux Craig , Griebsch Christine , Boland Lara , Wong Nadia , Bennett Peter , Wasinger Valerie C. 
Published: April 2023

AbstractBackgroundChronic enteropathy (CE) is common in dogs and can occur with multiple etiologies including food‐responsive enteropathy (FRE) and idiopathic inflammatory bowel disease (IBD).Hypothesis/ObjectiveTo study the protein profile and pathway differences among dogs with FRE, IBD, and healthy controls using serum proteome analysis.AnimalsNine CE dogs with signs of gastrointestinal disease and histologically confirmed chronic inflammatory enteropathy and 16 healthy controls.MethodsA cross‐sectional study with cases recruited from 2 veterinary hospitals between May 2019 and November 2020 was performed. Serum samples were analyzed using mass spectrometry‐based proteomic techniques.ResultsProteomic profiles showed marked variation in relative protein abundances. Forty‐five proteins were significantly (P ≤ .01) differentially expressed among the dogs with CE and controls with ≥2‐fold change in abundance. The fold change of dogs with IBD normalized to controls was more pronounced for the majority of proteins than that seen in the dogs with FRE normalized to control dogs. Proteins involving reactive oxygen species, cytokine activation, acute phase response signaling, and lipid metabolism were altered in dogs with CE.Conclusions and Clinical ImportanceCytokine alterations, acute phase response signaling, and lipid metabolism are likely involved in pathogenesis of CE. Although there are insufficient current data to justify the use of proteomic biomarkers for assessment of CE in dogs, our study identifies potential candidates.
Designing universal causal deep learning models: The geometric (Hyper)transformer
Authors: Acciaio Beatrice , Kratsios Anastasis , Pammer Gudmund 
Published: April 2023

AbstractSeveral problems in stochastic analysis are defined through their geometry, and preserving that geometric structure is essential to generating meaningful predictions. Nevertheless, how to design principled deep learning (DL) models capable of encoding these geometric structures remains largely unknown. We address this open problem by introducing a universal causal geometric DL framework in which the user specifies a suitable pair of metric spaces and and our framework returns a DL model capable of causally approximating any “regular” map sending time series in to time series in while respecting their forward flow of information throughout time. Suitable geometries on include various (adapted) Wasserstein spaces arising in optimal stopping problems, a variety of statistical manifolds describing the conditional distribution of continuous‐time finite state Markov chains, and all Fréchet spaces admitting a Schauder basis, for example, as in classical finance. Suitable spaces are compact subsets of any Euclidean space. Our results all quantitatively express the number of parameters needed for our DL model to achieve a given approximation error as a function of the target map's regularity and the geometric structure both of and of . Even when omitting any temporal structure, our universal approximation theorems are the first guarantees that Hölder functions, defined between such and can be approximated by DL models.
Study of NIT domain‐containing chemoreceptors from two global phytopathogens and identification of NIT domains in eukaryotes
Authors: Monteagudo‐Cascales Elizabet , Ortega Álvaro , Velando Félix , Morel Bertrand , Matilla Miguel A. , Krell Tino 
Published: April 2023

AbstractBacterial signal transduction systems are typically activated by the binding of signal molecules to receptor ligand binding domains (LBDs), such as the NIT LBD. We report here the identification of the NIT domain in more than 15,000 receptors that were present in 30 bacterial phyla, but also in 19 eukaryotic phyla, expanding its known phylogenetic distribution. The NIT domain formed part of seven receptor families that either control transcription, mediate chemotaxis or regulate second messenger levels. We have produced the NIT domains from chemoreceptors of the bacterial phytopathogens Pectobacterium atrosepticum (PacN) and Pseudomonas savastanoi (PscN) as individual purified proteins. High‐throughput ligand screening using compound libraries revealed a specificity for nitrate and nitrite binding. Isothermal titration calorimetry experiments showed that PacN‐LBD bound preferentially nitrate ( K D  = 1.9 μM), whereas the affinity of PscN‐LBD for nitrite ( K D  = 2.1 μM) was 22 times higher than that for nitrate. Analytical ultracentrifugation experiments indicated that PscN‐LBD is monomeric in the presence and absence of ligands. The R182A mutant of PscN did not bind nitrate or nitrite. This residue is not conserved in the NIT domain of the Pseudomonas aeruginosa chemoreceptor PA4520, which may be related to its failure to bind nitrate/nitrite. The magnitude of P. atrosepticum chemotaxis towards nitrate was significantly greater than that of nitrite and pacN deletion almost abolished responses to both compounds. This study highlights the important role of nitrate and nitrite as signal molecules in life and advances our knowledge on the NIT domain as universal nitrate/nitrite sensor module.
Validity of the Manchester triage system in the prioritization of patients with transient global amnesia in the emergency department
Authors: Zaboli Arian , Turcato Gianni , Nucera Bruna , Sibilio Serena , Rinaldi Fabrizio , D'Acunto Laura , Manganotti Paolo , Nardone Raffaele , Pfeifer Norbert , Brigo Francesco 
Published: April 2023

AbstractBackgroundThe Manchester Triage System (MTS) is one of the most widely used and studied triage systems in emergency departments (ED). MTS does not have a specific presentational flow chart for patients with transient global amnesia (TGA). The goal of this study was to determine the adequacy of priority code assignment for patients with TGA presenting at the ED and triaged using the MTS.MethodsThis is a single‐center observational retrospective study from January 01, 2013 to June 31, 2020. All patients with a medical diagnosis of TGA were considered. An audit was conducted on these triages to assess the correct application of MTS by the triage nurses. Correct triage was considered as a patient classified as yellow.ResultsDuring the study period, 216 patients with a diagnosis of TGA were considered. Of these 49.5% were classified as yellow, 13.0% were undertriage and classified as green or blue and 37.5% were overtriaged and classified as orange or red. The audit demonstrated that 98.8% of overtriaged patients and 57.1% of undertriage patients were triaged incorrectly. In addition, in 38 patients the triage nurse confused TGA with an acute neurological deficit suggestive of stroke or transient ischemic attack.ConclusionThe present study demonstrates an inability of MTS to correctly stratify patients with TGA. The results of the present study indicate the need for a specific flow chart for patients with neurological problems to improve the performance of MTS.
Perspectives on certification of community health workers: A statewide mixed‐methods assessment in Nebraska
Authors: Ern Jessica , Chaidez Virginia , Trout Kate E. , Karsting Kathy , Su Dejun 
Published: April 2023

AbstractObjectivesWhile the Community Health Worker (CHW) workforce in the United States has been growing, so far only 19 states certify CHWs. This study sought to identify perspectives on CHW certification among stakeholders in Nebraska, a state that has not established official certification for CHWs yet.DesignA concurrent triangulation mixed methods design.SampleStudy data came from a survey of 142 CHWs in Nebraska and interviews with 8 key informants employing CHWs conducted in 2019.MethodsLogistic regression was used to identify significant factors associated with favoring CHW certification, supplemented by thematic analysis of qualitative data from CHWs and key informants.ResultsThe majority (84%) of CHWs were in favor of a statewide CHW certification in Nebraska, citing community benefits, workforce validation, and standardization of knowledge as the main reasons. Participant characteristics associated with favoring CHW certification included younger age, racial minority, foreign born, education lower than bachelor's degree, volunteering as a CHW, and employed for less than 5 years as a CHW. Key informants employing CHWs were divided in whether Nebraska should develop a state certification program.ConclusionsWhile most CHWs in Nebraska wanted to have a statewide certification program, employers of CHWs were less sure of the need for certification.
Choosing not to choose—Patients' justification of a disengaged choice of primary care provider
Authors: Hoffstedt Caroline , Fredriksson Magnus , Winblad Ulrika , Holmström Inger K. 
Published: April 2023

AbstractA key underpinning of choice of health care provider is that patients make active and informed decisions which stimulate quality competition. By imitating the principles of a market in the steering of health care, patients thus assume the role of consumers. Few patients however neither consider alternative providers nor seek information about quality. The aim of this study was to investigate if and how patients engage in the role of being active and informed consumers in the setting of primary care, and how they argue for their choice. The study was based on semi‐structured interviews with 18 respondents in a municipality in mid‐Sweden. Respondents were purposefully sampled and interviews were analysed using an inductive thematic approach. Findings demonstrated that patients disengaged from choice by arguing, for instance, that they were satisfied with their current provider or because they perceived no differences in quality. Overall, results were in line with previous studies performed in US and European hospital settings, indicating that patients present some similar arguments regarding disengagement from choice irrespective of level of care or geographical setting. Arguments specifically related to the primary care level were that patients found it more important to achieve continuity in the patient‐doctor relationship than ‘shopping around’ for the best provider, or that they desired more profiled services to actively make a choice. In contrast to previous literature, patients refuted the ‘patient‐consumer’ role by referring to, for instance, the belief that care should be of equal quality independent of what choice they made.
Gene expression and expression quantitative trait loci analyses uncover natural variations underlying the improvement of important agronomic traits during modern maize breeding
Authors: Li Changyu , Li Yaoyao , Song Guangshu , Yang Di , Xia Zhanchao , Sun Changhe , Zhao Yuelei , Hou Mei , Zhang Mingyue , Qi Zhi , Wang Baobao , Wang Haiyang 
Published: April 2023

SUMMARYMaize (Zea mays L.) is a major staple crop worldwide, and during modern maize breeding, cultivars with increased tolerance to high‐density planting and higher yield per plant have contributed significantly to the increased yield per unit land area. Systematically identifying key agronomic traits and their associated genomic changes during modern maize breeding remains a significant challenge because of the complexity of genetic regulation and the interactions of the various agronomic traits, with most of them being controlled by numerous small‐effect quantitative trait loci (QTLs). Here, we performed phenotypic and gene expression analyses for a set of 137 elite inbred lines of maize from different breeding eras in China. We found four yield‐related traits are significantly improved during modern maize breeding. Through gene‐clustering analyses, we identified four groups of expressed genes with distinct trends of expression pattern change across the historical breeding eras. In combination with weighted gene co‐expression network analysis, we identified several candidate genes regulating various plant architecture‐ and yield‐related agronomic traits, such as ZmARF16, ZmARF34, ZmTCP40, ZmPIN7, ZmPYL10, ZmJMJ10, ZmARF1, ZmSWEET15b, ZmGLN6 and Zm00001d019150. Further, by combining expression quantitative trait loci (eQTLs) analyses, correlation coefficient analyses and population genetics, we identified a set of candidate genes that might have been under selection and contributed to the genetic improvement of various agronomic traits during modern maize breeding, including a number of known key regulators of plant architecture, flowering time and yield‐related traits, such as ZmPIF3.3, ZAG1, ZFL2 and ZmBES1. Lastly, we validated the functional variations in GL15, ZmPHYB2 and ZmPYL10 that influence kernel row number, flowering time, plant height and ear height, respectively. Our results demonstrates the effectiveness of our combined approaches for uncovering key candidate regulatory genes and functional variation underlying the improvement of important agronomic traits during modern maize breeding, and provide a valuable genetic resource for the molecular breeding of maize cultivars with tolerance for high‐density planting.
Insights into the evolutionary history of Diestramimini cave crickets (Orthoptera, Rhaphidophoridae)
Authors: Zhu Qidi , Zhou Zhijun , Guo Qi , Duan Yanhao , Wang Haijian , Shi Fuming 
Published: April 2023

AbstractDiestramimini is one of the two tribes of Aemodogryllinae and is mainly distributed in southern China and Southeast Asia. The intergeneric phylogenetic relationship and historical biogeography of this tribe remain unclear. Here, we present the first phylogenetic and biogeographical analyses of Diestramimini based on three mitochondrial (COI, 12S rRNA and 16S rRNA) and two nuclear (18S rRNA and 28S rRNA) gene fragments. The molecular phylogenetic inference strongly supports the monophyly of Diestramimini and recovers the sister‐group relationship between Diestramima + Tamdaotettix and Arboramima + Gigantettix. A new genus, Bidiestramima Zhu & Shi gen. n., is established and recovered as sister to all the remaining genera of Diestramimini. Moreover, a new species Bidiestramima hekouensis Zhu & Shi gen. et sp. n. is described. Mimadiestra is recovered as paraphyletic, and thus, we propose two new combinations based on the combination of morphological and molecular evidence: Bidiestramima dicha comb. n. and Tamdaotettix (Laotettix) gracilus comb. n. Divergence time estimation and reconstruction of ancestral areas indicate that Diestramimini in China may have originated from Southern Yunnan and Guangxi during the mid‐Oligocene and had two separate evolutionary routes. The diversification of Diestramimini has been driven by several dispersal and vicariance events since the Miocene, linked to the uplift of the Himalaya–Tibetan Plateau, the formation of the monsoon and climate fluctuations.
Motives of moduli spaces of bundles on curves via variation of stability and flips
Authors: Fu Lie , Hoskins Victoria , Pepin Lehalleur Simon 
Published: April 2023

AbstractWe study the rational Chow motives of certain moduli spaces of vector bundles on a smooth projective curve with additional structure (such as a parabolic structure or Higgs field). In the parabolic case, these moduli spaces depend on a choice of stability condition given by weights; our approach is to use explicit descriptions of variation of this stability condition in terms of simple birational transformations (standard flips/flops and Mukai flops) for which we understand the variation of the Chow motives. For moduli spaces of parabolic vector bundles, we describe the change in motive under wall‐crossings, and for moduli spaces of parabolic Higgs bundles, we show the motive does not change under wall‐crossings. Furthermore, we prove a motivic analogue of a classical theorem of Harder and Narasimhan relating the rational cohomology of moduli spaces of vector bundles with and without fixed determinant. For rank 2 vector bundles of odd degree, we obtain formulae for the rational Chow motives of moduli spaces of semistable vector bundles, moduli spaces of Higgs bundles and moduli spaces of parabolic (Higgs) bundles that are semistable with respect to a generic weight (all with and without fixed determinant).
Hybrid Genome Assemblies of 245 Avian and Broiler Barn Environment-Associated Escherichia coli Strains Isolated from Saskatchewan Broiler Farms
Authors: Sanderson Haley , Nnajide Chinenye R. , McCarthy Madeline C. , Singh Reema , Rubin Joseph E. , Dillon Jo-Anne R. , White Aaron P. 
Published: April 2023

Escherichia coli
infections in poultry cause significant morbidity and economic losses for producers each year. In a 3-year period, we collected and sequenced the whole genomes of
E. coli
disease isolates (
n
= 91), isolates from presumed healthy birds (
n
= 61), and isolates from 8 barn sites (
n
= 93) on broiler farms in Saskatchewan.