bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychomotricité et psychiatrie adulte
Authors: Ferre Dorothée 
Published: September 2023

La pratique psychomotrice, en psychiatrie adulte, reste peu connue et sa clinique rarement théorisée. Pourtant, elle a toute sa place dans le dispositif de soin. L’objet de cet écrit est de développer les axes de travail à partir d’une expérience de prise en charge psychomotrice auprès d’un patient accueilli en CMP, Mr L. Des incursions théorico-cliniques nourriront et soutiendront cette approche. S’appuyant, entre autre, sur les théories de D. ANZIEU, l’auteure fait le constat d’un manque de structuration de l’enveloppe psychomotrice de Mr L., (entendue ici dans le sens du Moi-Peau d’ANZIEU, c’est-à-dire « la figuration d’un Moi contenant à partir de l’expérience de la surface de la peau » 1 ). Elle amènera peu à peu le patient à trouver dans son propre corps des étayages suffisants pour fonder son sentiment de solidité interne, permettant de lier l’extérieur et l’intérieur, de réinvestir l’espace et de supporter la relation à autrui.
Technologie du temps de travail et travail non rémunéré dans le care rémunéré
Authors: Hayes Lydia J. B. , Argy Anne-Gaëlle 
Published: September 2023

Comment le travail non rémunéré s’est-il implanté dans le secteur britannique de l’aide à domicile ? Ce chapitre se concentre sur les perceptions du temps des aides à domicile et appréhende les contrats « zéro heure » et le contrôle électronique de la prestation de service comme des technologies du temps. Il montre la manière dont le temps se matérialise dans le travail. En fracturant la perception du « temps de l’horloge » en quatre cadrans distincts et en subordonnant économiquement le care dispensé, lui, en « temps de la nature », les technologies du temps affectent la conscience temporelle des aides à domicile. Le travail perçu dans le temps de la nature se matérialise ainsi sous forme de temps non rémunéré, tandis que le travail perçu dans le « temps de l’horloge » se matérialise sous forme de temps partiellement rémunéré. Il s’agit là d’un cadre temporel complexe pour le droit du travail, les protections juridiques étant souvent relatives à une mesure du temps de l’horloge fixée selon un unique cadran, également supposé mesurer le temps rémunéré.
Patients du capital
Authors: Puygrenier Lucas 
Published: September 2023

Chaque matin, des exilés se pressent au rond-point de Marsa, site informel de l’embauche de Malte. Souvent en vain, ils attendent d’obtenir un emploi journalier dans l’industrie du bâtiment. L’attente assidue de ceux qui forment ce que l’on pourrait appeler « l’armée industrielle de réserve » locale, destinée à n’être employée que par intermittence, seulement lorsque la production l’exige, invite à opérer un déplacement depuis la traditionnelle question du consentement au travail vers celle du consentement à l’attendre. En explorant l’art de la patience que prônent les journaliers, l’article montre que celui-ci régule la compétition pour l’emploi entre « réservistes » et s’impose comme un mode de domestication de l’obligation d’attendre, comme une modalité à travers laquelle la contrainte de l’attente devient consentie. En tant que prescription éthique populaire, la patience apparaît ainsi comme la déclinaison individuelle des lois générales dictées par le fonctionnement du capitalisme local et ses besoins erratiques en main-d’œuvre.
Pratique d’écriture diaire et construction professionnelle d’enseignant·es comme sujet et agent
Authors: Tschopp Geneviève 
Published: September 2023

Cet article présente le journal de bord professionnel comme activité spontanée et délibérée d’enseignant·es et en repère les impacts de subjectivation. Majoritairement étudié et stimulé en formation initiale, le journal l’est peu auprès des professionnel·les en exercice. Cette recherche compréhensive issue d’une thèse appréhende cette activité d’écriture diaire. La démarche d’enquête narrative menée auprès de six enseignant·es diaristes combine entretiens biographiques et entretiens d’explicitations. L’analyse des données notamment par timelines identifie des impacts de subjectivation associés à de l’autoévaluation de l’activité professionnelle. La discussion souligne tant l’espace de configuration et d’intelligibilité de l’expérience qu’offre l’écriture que son rôle dans la construction de l’enseignant·e comme sujet et agent, impacts relevant également du dispositif de recherche dialogique. Ouverture enfin à favoriser des dispositifs de formation « capacitants » pour les (futur·es) enseignant·es dans une logique de professionnalisation tout au long de la vie et centrée sur l’expérientiel.
An assessment of serum magnesium levels in critically ill patients: A prospective observational study
Authors: Laddhad Deepak S. , Hingane Vinayak , Patil Tushar Ramrao , Laddhad Dhruv Deepak , Laddhad Aishwarya Dhruv , Laddhad Shantanu Deepak 
Published: September 2023

ABSTRACT

Background:
A specific magnesium level is essential to be maintained to ensure appropriate neuromuscular excitability and cardiac function; an increase or decrease in its levels usually leads to critical abnormality. Hypomagnesemia in critically ill patients has many potential ramifications and is found to be an important factor in hindering their recovery. Thus, the study aimed to assess the serum magnesium levels in critically ill participants and explore its effect on their condition.

Methods:
A prospective observational study was conducted for 21 months, from February 2019 to October 2020, among all critically ill participants admitted to the medical intensive care unit (ICU) of a tertiary care hospital. The Acute Physiology and Chronic Health Evaluation II score questionnaire was used to determine the severity of their condition and blood samples were collected within 24 h of their ICU admission for analysis.

Results:
One hundred participants were enrolled, of which 40% were between the age group of 46 and 65 years and 71% were males. Among all participants with hypomagnesemia, 52% were diabetic, 19% had a history of alcohol use disorder, and 27% had normal calcium and potassium levels. Hypomagnesemia significantly correlated with a longer duration of ICU stay among participants.

Conclusion:
A significant correlation was observed between hypomagnesemia and increased ICU length of stay and mortality but not the duration of mechanical ventilation. Monitoring and appropriate supplementation of serum magnesium is recommended to limit further comorbidity and mortality in the critical care setting.
What is the right gentamicin dose for multiple trauma patients? A Monte Carlo simulation exploration study
Authors: Abbasi Mohammad Yaseen , Wiwattanawongsa Kamonthip , Chaijamorn Weerachai , Charoensareerat Taniya , Doungngern Thitima 
Published: September 2023

ABSTRACT

Background:
The appropriate dose of gentamicin is important to prevent and treat infections. The study aimed to determine the optimal dose of gentamicin to achieve the probability of pharmacokinetic/pharmacodynamic (PK) targets for efficacy and safety in multiple trauma patients.

Methods:
PK parameters of gentamicin in multiple trauma patients were gathered to develop a one-compartment PK model for prediction. The Monte Carlo simulation method was performed. The 24-h area under the concentration time curve to the minimum inhibitory concentration ratio (AUC24h/MIC) ≥50 was defined for the infection prevention target. AUC24h/MIC ≥110 or the maximum serum concentration to MIC ratio ≥8–10 was for the treatment of serious Gram-negative infection target. The risk of nephrotoxicity was the minimum serum concentration ≥2 mg/L. The optimal dose of gentamicin was determined when the efficacy target was >90% and the risk of nephrotoxicity was lowest.

Results:
The optimal gentamicin dose to prevent infection when the MIC was <1 mg/L was 6–7 mg/kg/day. A higher dose of gentamicin up to 10 mg/kg/day could not reach the target for treating serious Gram-negative infection when the expected MIC was ≥1 mg/L. The probability of nephrotoxicity was minimal at 0.2–4% with gentamicin doses of 5–10 mg/kg/day for 3 days.

Conclusions:
Once daily gentamicin doses of 6–7 mg/kg are recommended to prevent infections in patients with multiple trauma. Gentamicin monotherapy could not be recommended for serious infections. Further clinical studies are required to confirm our results.
S100B as a predictor of delirium in critically ill obstetric patients: A nested case–control study
Authors: Shyam Radhey , Solanki Monam , Patel Munna Lal , Sachan Rekha , Ali Wahid 
Published: September 2023

ABSTRACT

Background:
Delirium is a neuropsychiatric illness that lasts for a short period of time. The incidence of delirium in the intensive care unit (ICU) varies from 20% to 80%.

Methods:
A nested case–control study was carried out in the obstetric ICU. Individuals were divided into three groups: critically ill obstetric women who had delirium on admission (Group A), women who developed delirium within follow-up of 7 days (Group B), and women who did not develop delirium after follow-up of 7 days (Group C). The APACHE II score was used to assess critical illness severity. The Richmond Agitation-Sedation Scale was used to assess the alertness or sedation level of patients, and the Confusion Assessment Method (ICU scale) was used to assess the presence of delirium. S100B was measured by human S100B calcium-binding protein B ELISA kit (Elabscience Biotechnology, Houston, USA).

Results:
Severe preeclampsia and antepartum eclampsia were significantly associated with delirium. S100B levels in Group B were found to be significantly higher than those in Group C. S100B levels were higher in patients with >2 morbidities in comparison to patients with two morbidities. At a cutoff value of >169.25 pg/ml, S100B had a sensitivity of 74% and a specificity of 87.2% to discriminate cases of delirium from nondelirium.

Conclusion:
The rise in S100B levels was approximately three times greater in those who developed delirium as compared to those who did not. It is a more specific predictor of delirium.
The optimal time for endotracheal intubation in subjects with coronavirus disease 2019 pneumonia: A retrospective observational study
Authors: Nadeem Rashid , Nadeem Nadia , Albwidani Rawan Mohamad , Falih Fatima Hakim , Husain Hatim Riyaz , Krrak Ahmad Zouhir , Mathews Manoj Pazhampallil , Hussein Karim Said Hammouda , Abdulkarim Fatema , Dar Farooq 
Published: September 2023

ABSTRACT

Background:
The optimal timing of intubation has been debated among healthcare professionals, current studies do not show any differences between early and late intubation. most studies failed to show any significant difference in clinical outcomes between early or late intubation.

Methods:
The study was conducted as a retrospective review of subjects with confirmed coronavirus disease 2019 admitted to the Dubai Hospital intensive care unit (ICU). Study variables included time to intubation, duration of supplemental oxygen requirement >15 L/min, and cumulative duration of tachypnea and tachycardia while on the aforementioned oxygen requirement on this oxygen usage level. Each time duration was assessed for correlation with clinical variables including mortality and length of stay in ICU and hospital.

Results:
Subjects who require endotracheal intubation within 4 h after the start of oxygen >15 L/min have lower survival (P = 0.03). Subjects who have tachypnea on the aforementioned oxygen requirement for 6–19.5 h (P = 0.01) before they require intubation have better survival. No duration of tachycardia has any significant effect on survival. Only the duration of invasive mechanical ventilation (MV) correlated with the hospital length of stay.

Conclusions:
Subjects who require endotracheal intubation within 4 h after the start of oxygen >15 L/min have lower survival. The optimal time for intubation is after tachypnea of 6 h but before 19.5 h. No duration of tachycardia has any significant effect on survival. Only the duration of invasive MV correlated with the hospital length of stay.
Relationship between the rate of fluid resuscitation and acute kidney injury: A retrospective cohort study
Authors: Reddy Swetha , Hu Bo , Kashani Kianoush 
Published: September 2023

ABSTRACT

Background:
Septic shock is the leading cause of acute kidney injury (AKI) in critically ill patients. The foundation of early septic shock management includes early fluid resuscitation, but the association between fluid resuscitation rates and kidney outcomes remains unclear. This investigation examines the association between fluid resuscitation rate and AKI recovery.

Methods:
In the medical intensive care unit of Mayo Clinic Rochester, adult patients with AKI and septic shock were retrospectively studied from January 1, 2006 to May 31, 2018. The surviving sepsis campaign recommends an initial fluid bolus of 30 ml/kg for sepsis resuscitation. The cohort of patients was divided into three groups based on the average fluid resuscitation time (<1 h, 1.1–3 h, >3 h) and the corresponding fluid rate ≥0.5, 0.17–0.49, and <0.17 ml/kg/min, respectively. The primary outcome was the recovery of AKI on day 7. To account for potential confounders, multivariable regression analyses were conducted.

Results:
After meeting the eligibility, 597 patients were included in the analysis. The AKI recovery was considerably different among the groups (P = 0.006). Patients in group 1 who received fluid resuscitation faster had a higher rate of AKI recovery (53%) compared to group 2 and group 3 (50% and 37.8%).

Conclusion:
In septic shock patients with AKI, a higher fluid resuscitation rate of 30 ml/kg IV fluids within the 1st-h sepsis diagnosis (i.e., >0.50 ml/kg/min) lead to higher AKI recovery compared with slower infusion rates.
Cross-Sectional Study of Self-Concept and Alexithymia among Hijra Community of Rohtak, Haryana
Authors: Singh Himanshi , Kumar Pradeep 
Published: September 2023

Introduction:
The Indian Hijra community encompasses persons with a variety of gender identities and sexual orientations, thus forming culturally unique gender group. The sociocultural aspects of Hijras have frequently been the subject of research by anthropologists and sociologists, but there is a dearth of data regarding the mental health problems in them.

Methodology:
The aim of the study was to assess the self-concept and alexithymia in Hijra community using Self-Concept Inventory and Toronto Alexithymia Scale-20 Hindi.

Results:
The study on thirty Hijras indicated that most of the individuals of Hijra community (96.7%) have low self-concept and only one had average self-concept. While 30% of the sample was nonalexithymics, 26.7% individuals had possible alexithymia and 43.3% were alexithymics. Self-concept was seen to be negatively correlated with alexithymia among individuals of Hijra community.

Conclusion:
The findings can help clinicians and policymakers to focus on the mental health awareness among these individuals.
Distal Factors of Suicidal Behavior among Patients with Substance Use Disorder: A Comparative Study
Authors: Verma Aparna , Gupta Preeti , Kumar Vikas 
Published: September 2023

Background:
According to the World Health Organization, substance dependence is persistent or sporadic drug use inconsistent with or unrelated to acceptable medical practice. Substance dependence is showing a rising trend all over the world, and these disorders are rapidly recognized throughout in India. It is considered as a major cause of preventable ill health, social harm, and premature death throughout the population. As compared to the general population, those with substance use disorders are 5.3% more likely to die from suicide. There are several distal or predisposing risk factors associated with suicidal behavior such as personality traits, childhood trauma, and family history of suicide. Therefore, the present study is to compare and examine the distal factors of suicidal ideation (SI) and suicidal attempt (SA) with patients without SI and SA (WS) in patients with substance dependence.

Materials and Methods:
This was a cross-sectional observational study conducted at the inpatient departments of Central Institute of Psychiatry, Ranchi. Purposive sampling of sixty patients was done to further divide them into Group 1 (SI), Group 2 (SA), and Group 3 (WS). The sample was purposively collected to include sixty patients with substance dependence. They were screened by using the Addiction Severity Index scale, and Beck Scale for Suicidal Ideation (BSSI), Suicide Intent Scale, Childhood Trauma Questionnaire (CTQ), and the NEO five-factor inventory-3 (NEO-FFI-3) were administered to assess SI, SA, childhood trauma and personality traits, respectively.

Results:
The present study reveals that all the personality domains except conscientiousness on NEO-FFI 3 may have importance in differentiating the substance-dependent patients with SI/SA from WS patients. Only physical and emotional abuse on CTQ may be a significant distal factor for suicidal thoughts and behavior, whereas physical abuse may have more significance for SAs in substance dependence patients. Family history of suicide was not significant in patients with SI/SA.

Conclusions:
These findings may assist in formulation of therapeutic strategies for suicidal patients of substance dependence.
Urinary microRNA-10a levels in diagnosis and prognosis of urinary bladder cancer
Authors: Zaidi Noorin , Siddiqui Zainab , Sankhwar Satya N. , Srivastava Anand N. 
Published: September 2023

ABSTRACT

Background:
Urinary bladder cancer (UBC) is a disease quite common in developed countries; however, its incidence is increasing in developing countries as well. The diagnosis of UBC is generally based on a number of methods, of which urinary cytology is a very commonly used one. But it is not very reliable. Therefore many new markers and methods are being investigated to make non-invasive diagnosis of UBC easy and reliable.

Objective:
This study was carried out to find the usefulness of microRNA (miRNA)-10a as a diagnostic and prognostic marker in non-muscle-invasive urinary bladder carcinoma.

Material and Method:
Twenty patients with UBC were taken as cases with 20 controls. Urine cytological examination was done, as well as histopathological examination of tumor tissue of cases. Urinary miRNA-10a estimation of both the cases and controls were done.

Result and Conclusion:
It was found that miRNA-10a is significantly high in urine of patients with UBC. Its value also significantly correlated with the grade and stage of the tumor. Hence it can be concluded that urinary miRNA-10a is a potential candidate in the diagnosis and prognosis of UBC.
Warthin-like papillary carcinoma thyroid
Authors: Kalantri Suman H. , D’Cruze Lawrence , Barathi G. , Singh Balaji K. 
Published: September 2023

ABSTRACT
Solitary thyroid nodule should raise a suspicion of malignancy, which is very common in middle-aged females. Papillary carcinoma thyroid is the most common thyroid malignancy. Warthin-like papillary carcinoma is one of its rare variants. It has a frequent association with Hashimoto’s thyroiditis. Here, we report a case of 43-year-old female who presented with swelling in the anterior aspect of neck for 1 month. Fine-needle aspiration cytology features were suggestive of papillary carcinoma thyroid and biopsy confirmed the diagnosis of Warthin-like papillary carcinoma thyroid. This variant is of great clinical and prognostic significance as it carries an excellent prognosis.
A rare case of cerebellar anaplastic pleomorphic xanthoastrocytoma
Authors: Agrawal Krati , Verma Kartavya Kumar , Hussain Nighat , Sarangi Sujata 
Published: September 2023

ABSTRACT
Pleomorphic xanthoastrocytoma (PXA) is a low-grade glioma comprising 1% of all astrocytomas with an extremely rare anaplastic counterpart usually found in young adults. These tumors are most often cerebral in origin and their presentation in the elderly signifies poor prognosis. As these tumors are an important differential of glioblastoma, diagnosing them accurately is essential for management. We present a 68-year-male with positive cerebellar signs and clinico-radiological impression of cerebellar metastatic deposits, subsequently diagnosed as cerebellar PXA with anaplastic features. The case in discussion is unique in its age, site, and grade of presentation, with key histological features rebuking the clinical and radiological diagnosis of metastasis. The rarity and ambiguous management protocol of these tumors make their documentation an important addition to the existing literature with emphasis on possibility of late presentation and at sites other than the cerebrum.
Clinicopathological and prognostic characteristic features of triple negative and nontriple negative breast cancer at a tertiary care hospital
Authors: Mohapatra Manisha 
Published: September 2023

ABSTRACT

Context:
Carcinoma breast is a complex disease having diverse clinical, histopathological, and immunohistochemical features. Basing on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2) status, these tumors are divided into triple-negative breast cancers (TNBC) where tumor cells are negative for all three receptors and nontriple negative breast cancer (non-TNBC) where tumor cells are positive for one or two or all. The clinicopathological and characteristic prognostic features are highlighted here.

Aim:
The aim of this study is to evaluate the clinicopathological and prognostic features of TNBC and non-TNBC cases diagnosed in our hospital setting.

Settings and Design:
Single institution, retrospective study conducted over 7 and half years.

Subjects and Methods:
Histopathologically confirmed breast cancer cases with ER, PR, and HER2 receptor assessment were categorized into TNBC and non-TNBC. Detailed study on clinicopathological and prognostic features including pathological prognostic stage as per 8th AJCC was done in cases who underwent modified radical mastectomy.

Statistical Analysis Used:
Data were analyzed in percentage and presented in tables and charts.

Results:
The present study included 794 cases consisting of 253, 31.9% TNBC and 541, 68.1% non-TNBC cases. The mean age of TNBC and non-TNBC cases was 50.4 years and 51.7 years, respectively. Coagulative necrosis, lymphovascular invasion, lymph nodal metastasis, higher histopathological tumor grade, and NPI were observed in higher percentage of TNBC cases, i.e., 19 (10.9%), 21 (11.6%), 105 (57.7%), 127 (69.8%), and 149 (81.9%) cases, respectively, than non-TNBC seen in 18 (6.6%), 24 (8.8%), 135 (49.6%), 165 (60.7%), and 194 (71.3%) cases, respectively. Further, 25 (13.7%) TNBC and 1 (0.4%) non-TNBC case were upstaged, whereas 130 (47.8%) non-TNBC and 2 (1.1%) TNBC cases were downstaged by the pathological prognostic stage.

Conclusions:
TNBC is more aggressive having a poor prognosis than non-TNBC.
Prolonged response to Tyrosine Kinase Inhibitors followed by Immunotherapy in metastatic hepatocellular carcinoma: A rare case report
Authors: Roy Parag , Parthasarathy K.M. 
Published: September 2023

ABSTRACT
The overall prognosis of hepatocellular carcinoma (HCC) is dismal and 5-year survival rate is 14.8%. We report a case of HCC coinfected with hepatitis C virus (HCV) and tumor thrombosis in the portal vein that was initially started on sorafenib followed by lenvatinib and nivolumab. On radiological imaging, there was a good partial response (PR) after starting nivolumab. A female 56 years of age presented with HCC coinfection with HCV, tumor thrombosis growing to the right portal vein. She received 6 months of sorafenib starting from April 2019 and was then switched to lenvatinib due to progressive disease. She continued lenvatinib for 11 months following which she developed new metastatic lesions where she was started on nivolumab. After 4 months of nivolumab, her alpha-fetoprotein decreased and there was a radiological PR. She is currently on nivolumab, with a total duration of response of 24 months on sorafenib followed by lenvatinib and lastly on nivolumab. Hence, tyrosine kinase inhibitors and immunotherapy can be effective lines treatment for advanced HCC and can give durable response duration, and probable radiological PR can be achieved with Nivolumab.