bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution to the identification of medicinal plants used against COVID-19 in North-West Morocco
Authors: Laaribya S. , Alaoui A. , Azmi R. 
Published: March 2023

The coronavirus disease 2019 (COVID-19) affects humans, who are now developing a milder form of the illness. In addition to the use of available drugs, the local populations in Morocco used medicinal plants during the pandemic. The current study aimed to document and to research the level of use of traditional medicine using plants in Morocco. Ethnobotanical surveys were conducted on the perceptions and level of use of plants through a case study in North-West Morocco. The methodology is based on targeted surveys, from April to September 2021, of households that have had cases if nfection with COVID-19. Five hundred surveys were randomly and systematically distributed in the study area to highlight the medicinal use of plants to treat COVID-19 and its consequences for health and well-being. The results showed the attachment of the populations to traditional medicine with the use of plants available in the study area (local forest area and herbalists). The 23 species used by the populations in question against COVD-19 belong to 12 families. The analysis shows the dominance of the Lamiaceae family with nine species, followed by Asteraceae with three species. The Lamiaceae family have proven marked performance in the fight against COVID-19. The results obtained offer orientations for the enhancement of the beneficial effects of traditional medicine and clinical trials remain to be carried out. The current results highlight that flora can be a source for the discovery of medicinal agents active against COVID-19.
Physicochemical quality indicators of honey: An evaluation in a Ukrainian socioecological gradient
Authors: Zhuk A. , Sytnikova I. , Fylypchuk T. , Bahlei O. , Shkrobanets O. , Danihlík J. , Moskalyk H. , Panchuk I. , Burkut V. , Angelstam P. , Fedoriak M. 
Published: March 2023

Physical and chemical quality indicators of 65 polyfloral honey samples from three administrative districts of Chernivtsi region in South Western Ukraine were studied. The chosen administrative districts were Putyla (representing the ‘Traditional villages’ stratum), Storozhynets (the ‘Intermediate’ stratum) and Khotyn (the ‘Intensive agriculture’ stratum), which reflect a steep gradient of social and ecological conditions such as land cover and land use, level of economic development, culture and demography. The quality of honey was determined in accordance with the requirements of the Ukrainian national standard and the EU Directive relating to honey (or Codex Alimentarius Honey Standard) by using the following indicators: reducing sugars and moisture content, diastase activity, free acidity, pH, electrical conductivity, hydroxymethylfurfural (HMF) and proline content. The profile of carbohydrates was analyzed, in particular glucose, fructose, sucrose, maltose, trehalose, melezitose, raffinose. The ratio of fructose to glucose (F/G) was determined. All tested samples complied with the international standards for the mass fraction of reducing sugars, diastase activity and hydroxymethylfurfural content. For physical and chemical parameters, the studied honey samples were of high quality. The content of the reducing sugars in the honey samples varied within the range of 66.0–97.6%. The fructose content ranged from 342 to 549 mg/g, and the glucose content variation ranged within 283–517 mg/g. The average fructose/glucose ratio was 1.2 for honey samples from the three studied districts. Besides fructose and glucose, some oligosaccharides, such as maltose, trehalose and melezitose, were found in the examined honey. Melezitose was detected in the honey samples from ‘Traditional village’ (21 samples) and ‘Intermediate’ (5 samples) districts. The total variability of HMF content in the studied 65 honey samples from apiaries in the three districts of Chernivtsi region ranged from 0.19 to 30.8 mg/kg. The minimum moisture content was found to be 16.2% (in the ‘Traditional village’ and ‘Intermediate’ strata), and 22.2% was the maximum (in the ‘Intermediate’ stratum). Our studies have shown that free acidity of the samples varied within the range 13.5 to 58.0 meq/kg. Proline content variability for the three studied geographical areas ranged from 82.3 to 1201.2 mg/kg. The studied samples of honey had a low pH level (~ 3.7), high content of proline (~ 513 mg/kg) and reducing sugars (~ 80%), which indicates its nutritional value and naturalness. Deviations from the honey standards in moisture content, acidity and electrical conductivity was revealed in 8% to 10% of all samples.
Nitrogen-fixing, phosphate-potassium-mobilizing ability of Rahnella bacteria isolated from wheat roots
Authors: Shakirov Z. S. , Mamanazarova K. S. , Yakubov I. T. , Zakiryaeva S. I. , Khamidova K. M. 
Published: March 2023

As the number of people on earth increases, so does the need for food. Providing the population with environmentally friendly agricultural food is one of the urgent problems of our time. Currently, the main direction of modern organic farming is the use of biofertilizers. Bacterial preparations are capable of influencing the physiological processes of plants in small quantities, leading to increase in plant productivity. The objective of this work was to study rhizobacteria associated with wheat roots. For this purpose, we took more than 100 isolates of rhizobacteria from the rhizosphere and root surface of wheat plants grown in irrigated fields of Tashkent, Syrdarya, Andijan, Kashkadarya regions. Rhizobacteria were grown on nutrient media of Döbereiner, Ashby, Pikovsky, and Zack, and 25 isolates of associative rhizobacteria were selected based on the characteristics of absorption of molecular nitrogen, mobilization of phosphorus and potassium. They actively dissolved Сa3(PO4)2 and KAlSiO4 for 3 days. They were found to produce organic acids. In organic farming, nitrogen-fixing, phosphorus- and potassium-mobilizing rhizobacteria are of great practical importance, while our experiments on obtaining biological products are considered as an environmentally friendly and cost-effective way to increase crop yields. From the surface of wheat roots grown in different zones of Uzbekistan, when screening for nitrogen fixation, we selected 3 isolates with acetylene reductase activity of 79–91 nmol C2H4/flacon/24h. We determined that bacteria completely mobilized phosphate, forming 100% acid when grown in a medium containing Ca3(PO4)2 for 5 days. The ability of the bacteria to mobilize potassium was studied on a nutrient KAlSiO4-containing medium. The bacteria were observed to mobilize potassium, forming 90–100% acid within 15 days. Based on the study of the 16S rRNA gene of bacteria, we identified rhizobacteria UT3, UT4, and UT9 as Rahnella aquatilis.
Bioclimatic projection of the ecological niche of curly mallow (Malva verticillata) based on the forecast of the dynamics of the geographical range in the context of global climate change
Authors: Panchenko K. 
Published: March 2023

Curly mallow (Malva verticillata L.) is a promising species for cultivation to obtain valuable compounds for the application in medicine, and this species can be used in the bioenergy system to provide industry with alternative energy sources. For the highest economic efficiency, the practical use of this species requires the development of complex measures related to both agrotechnologies and selective breeding. Such measures require resources and there is an urgent problem of assessing the prospects of such investments taking into account the global climate change. Therefore, the problem that we aimed to solve was the assessment of how the global climate change would impact the curly mallow in general in the global context, as well as in the conditions of Ukraine in the next 50–70 years. The database of the Global Biodiversity Information Facility (GBIF) contains 2,104 records of curly-leaved mallow. This species is found on all the continents except Antarctica. Asia accounts for 39.1% of the species’ range, Europe – 53.3%, Africa – 3.6%, North America – 3.2%, South America – 0.1%, Australia – 0.8%. The modelling of M. verticillata response to the climatic factors showed that the best response models were V (in 31.6% of cases) and VII (in 36.8% of cases). Model V characterizes unimodal bell-shaped asymmetric response, and model VII – bimodal asymmetric response. The species response to the mean annual temperature is asymmetric bell-shaped with a shift to the right. The optimal average annual temperature for this species is 9.1 °C. Comparing the distribution of available resources and their use is the basis for identifying the features of the ecological niche of the species. The MaxEnt approach indicates that Southeast Asia and Europe have the most favourable conditions for the existence of this species. Changes in the climatic conditions over the next 50–70 years will make the conditions for the life of M. verticillata in the southern hemisphere unfavourable, and the favourable conditions for it in the northern hemisphere will shift significantly to the north. At the same time, conditions in the autochthonous range of the species will become unfavourable. Obviously, if not for the significant potential of the species to disperse, it would have died out as a result of the significant climate change. The area where favourable conditions for the species will remain unchanged is Central Europe. Conditions in Eastern Europe, including Ukraine, will moderately improve. The results indicate the perspective of the cultivation of curly mallow in Ukraine in the future.
Effect of liposomal drug based on interferon and extract from Silybum marianum on antioxidative status of bulls against the background of contamination of fodders by cadmium and plumbum
Authors: Gutyj B. V. , Martyshuk T. V. , Parchenko V. V. , Kaplaushenko A. H. , Bushueva I. V. , Hariv I. I. , Bilash Y. P. , Brygadyrenko V. V. , Turko Y. I. , Radzykhovskyi M. L. 
Published: March 2023

The balance between anti- and prooxidants in animal organisms in general and in each cell in particular is responsible for the regulation of many metabolic processes that provide immunocompetence, growth, development and protection of animals from oxidative stress, related to inflow of cadmium and plumbum. Therefore, the objective of our study was the influence of a liposomal drug based on interferon and milk thistle (Silybum marianum (L.) Gaertn.) on the antioxidative status of the organism of bulls in the conditions of cadmium and plumbum loading. The experiments were performed on six-months-old Black Motley dairy cattle. The fodders in the farm were determined to contain high levels of plumbum and cadmium. The liposomal drug Lipointersyl inhibited the lipid peroxidation processes in the bulls. The drug components promoted the decrease in the level of intermediate and end products of lipid peroxidation, in particular 22% decrease in the level of diene conjugates and 20% decrease in TBA-active products. Intramuscular injection of the liposomal drug to bulls of the experimental group strengthened the antioxidant protection of their organism. On the 30th day of the experiment, blood from experimental group animals was seen to have a 9.8% increase in reduced glutathione. Assay of the enzymatic link of the glutathione system revealed that the activity of glutathione peroxidase and glutathione reductase in the blood of the animals that had been injected the liposomal drug Lipointensyl had increased by 24.0% and 27.7% respectively by the 30th day of the experiment. The experiments conducted on young cattle demonstrated that intermuscularly injected the Lipointensyl liposomal drug – against the background of cadmium and plumbum loading – promoted the activation of the glutathione system of antioxidant protection as a result of increase in the activity of its enzymatic and non-enzymatic links. The study of catalase and superoxide dismutase activities revealed that on the 30th and 40th days of the experiment, the activity of those enzymes varied within the physiological norms. Therefore, the analyzed Silybum marianum-based liposomal drug has antioxidant properties, it is recommended for young cattle in the conditions of contamination with heavy metals in order to prevent the development of oxidative stress.
Аntibiotic resistance of bacterial cultures isolated from the feral pigeon (Columba livia) and starling (Sturnus vulgaris) at a solid waste landfill
Authors: Dementieieva Y. Y. , Muzyka N. , Muzyka D. , Chaplygina A. B. 
Published: March 2023

Resistance to antibiotics is well-known global phenomenon. There are places contributing to the development of antibiotic resistance such as waste landfills, especially ones that accept medical waste which did not undergo disinfection and livestock waste with bacteria not sensitive to antibiotics. An extensive system of transfer of antibiotic resistant microorganisms is formed on these territories (zoochory, groundwater, transport etc.). The aim of the research was to determine the species composition of bacteria isolated from birds of Derhachi municipal solid waste landfills in Kharkiv city, Ukraine. Also, we determine the sensitivity of bacterial isolates to a number of standard antibiotic drugs. We collected droppings of feral pigeons (Columba livia Gmelin, 1789; Columbidae) and starlings (Sturnus vulgaris Linnaeus, 1758; Sturnidae) during the winter period in 2020/2021; both species are dominants of waste landfills. We isolated 15 bacteria species of 4 families by bacteriological methods (growing on simple and selective media and identification by biochemical properties): Enterobacteriaceae (Enterobacter asburiae, E. dissolvens, E. cancerogenus, E. cloacae, E. sakazakii, Escherichia coli, Klebsiella terrigena, K. ornithinolytica, Citrobacter freundii, Proteus mirabilis), Yersiniaceae (Serratia ficaria, S. rubidaea, S. entomophila), Morganellaceae (Providencia stuartii) and Pseudomonadaceaе (Pseudomonas aeruginosa). Sensitivity was determined by the disk-diffusion method to 18 antibiotics. Ten isolates turned out to be multiresistant-resistant to three or more classes of antimicrobial drugs. A promising direction for future research is the determination of the pathogenicity of the isolates and checking the roles of birds of Derhachi solid waste landfills as reservoirs of pathogens. Currently, it can be assumed that large concentrations of synanthropic birds (especially those that forage on solid waste landfills) with a high probability are reservoirs of many bacteria, in particular those that have developed resistance to drugs.
Influencia del Mantenimiento Productivo Total en la productividad del área de producción de una empresa de cultivo de frutas en la ciudad de Nepeña – Perú
Authors: Ramirez Campos Estefani Siomara , Villar Tiravantti Lily Margot , Saldaña Bernuy Luis Fernando , Chucuya Huallpachoque Roberto Carlos 
Published: March 2023

La presente investigación tuvo la finalidad de aplicar el mantenimiento productivo total en la planta de conservas para incrementar la productividad de la empresa Los Paltos S.A.C. La investigación fue de tipo aplicada del diseño pre experimental con una pre y post prueba respectivamente, así mismo la muestra estuvo dada por los 9 equipos estáticos del área de producción. Para el diagnóstico se realizó el análisis del VSM, el cual se determinó el lead time de cada proceso, obteniendo que los procesos de mayor tiempo de ciclo fueron la selección y el lavado con 1.3 s/kg, escaldado 0.75 s/kg, el llenado con 1.20 s/kg, la esterilizadora con 0.33 s/kg y sellado 0.54 s/kg, obteniendo un OEE que fue de 86.17, por tal motivo la productividad inicial no fue la esperada obteniendo un 86.76%, utilizando para su solución los pilares del TPM, como el mantenimiento planificado mediante capacitaciones, cumpliendo un 100% de cumplimiento, el mantenimiento planificado mediante un plan rutinario, cumpliendo un 94.55% de cumplimiento y el mantenimiento de calidad mediante un manual de buenas prácticas, reduciendo las fallas en un 500% y un 36% de defectos. Concluyendo que la aplicación del TPM aumentó la productividad total en un 3.50%.
A study on evaluation of sino-nasal outcome test-22 scores in chronic rhinosinusitis patients undergoing functional endoscopic sinus surgery in a tertiary care centre
Authors: Santhaiah Kakumanu , Kornepati Lavanya Lakshmi , Devi Pindiprolu Kameswari 
Published: March 2023

Background: Chronic rhinosinusitis (CRS) is defined as an inflammation of the nose and paranasal sinuses and is characterized by two or more cardinal symptoms like nasal blockage/obstruction/congestion, nasal discharge (anterior/posterior nasal drip), facial pain/ pressure, reduction or loss of smell.
Methods: The 55 patients diagnosed with CRS with and without nasal polyps undergoing functional endoscopic sinus surgery were included in this study, whose sino-nasal outcome test 22 (SNOT-22) scores were compared both pre operatively and post op, 3 months after functional endoscopic sinus surgery.
Results: Total score of SNOT-22 was significantly lower in CRS patients post-operatively when compared to pre-operative score of SNOT-22 (p<0.0001).
Conclusions: Functional endoscopic sinus surgery effectively improved quality of life of patients with CRS.
HIV/AIDS Diagnosis and the Importance of Counseling and Confidentiality: A Case Report
Authors: Khademi Nahid , Asghari Fariba 
Published: March 2023

Confidentiality in AIDS patients is one of the necessities of medical ethics, which has attracted the attention of policymakers in the health field in the last few decades because, on the one hand, it increases the trust between patients and doctors. On the other hand, it encourages them to adhere to treatment and do necessary care to patients in order to prevent the transmission of the disease to others. However, it may lead to a breach of benevolence and others’ right to health and cause problems in providing health care. Here we discuss a practical solution for this problem through a clinical case presentation.
Comparison of the hemodynamic effects of etomidate-midazolam and ketamine-midazolam combinations in anesthesia induction in coronary artery bypass surgery
Authors: KÖMÜRCÜ Özgür , CAMKIRAN FIRAT Aynur , BAYRAKTAR Nilüfer , SEZGİN Atilla , ARSLAN Gülnaz 
Published: March 2023

Aims: We aimed to compare the effects of anesthesia induction on hemodynamic parameters of ketamine-midazolam or etomidate-midazolam combinations and coronary artery bypass grafting surgery.
Material and Methods: 40 adult patients undergoing CABG were randomly allocated into two groups for this prospective randomized double-blinded study. Ketamine group (n = 20) and Etomidate group (n = 20). Intraoperative and postoperative hemodynamic variables, adrenal gland functions and intensive care period were compared after anesthesia induction with etomidate and ketamine.
Results: Perioperative hemodynamic parameters were not significantly different between the groups. Despite similar baseline measurements, cortisol levels were significantly higher 5 minutes after induction, during rewarming, and after ACTH stimulation test at postoperative day 1 in group ketamine than group etmidate. The groups were not significantly different in terms of duration of postoperative mechanical ventilation, frequency of postoperative delirium, and intensive care unit and hospital lengths of stay.
Conclusion: Ketamine-midazolam combination is an acceptable alternative to etomidate-midazolam combination in terms of hemodynamic stability. Compared with the ketamine-midazolam combination, the etomidate-midazolam combination significantly decreased cortisol levels during the intraoperative and early postoperative periods
Pengaruh Jenis dan Kosentrasi Bahan Tambahan terhadap pertumbuhan Jamur Tiram Coklat (Pleurotus pulmonarius)
Authors: MU'AFA RAFID HILMY , Ratnaningtyas Nuniek Ina , Ekowati Nuraeni 
Published: March 2023

Jamur tiram coklat (Pleurotus pulmonarius) merupakan salah satu jenis jamur kayu yang dapat dibudidayakan, namun belum populer bagi pembudidaya dan konsumen jamur tiram di Indonesia. Bahan medium tanam memberikan hasil yang berbeda, bergantung pada perbandingan komposisi yang diberikan. Penelitian ini bertujuan untuk mengetahui pengaruh jenis dan konsentrasi bahan tambahan yang berbeda terhadap pertumbuhan jamur tiram coklat serta mengetahui jenis dan konsentrasi bahan tambahn yang paling baik untuk pertumbuhan jamur tiram coklat.
Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) Faktorial yang terdiri atas perlakuan sebagai berikut: faktor jenis bahan tambahan, yaitu dedak padi, tepung jagung, polar, dan tepung gandum, serta faktor konsentrasi bahan tambahan yang berbeda, yaitu 0%, 5%, 10%, 15%, dan 20%. Masing-masing perlakuan diulang sebanyak 4 kali, sehingga terdapat 80 unit percobaan. Data yang diperoleh dianalisis menggunakan analisis ragam (ANOVA) dengan tingkat kesalahan 5% dan dilanjutkan dengan Duncan Multiple Range Test (DMRT) dengan tingkat kesalahan 5%.
Hasil penelitian menunjukkan bahwa interaksi antara jenis dan konsentrasi bahan tambahan berpengaruh terhadap produksi jamur tiram coklat (P < 0,05). Jenis bahan tambahan dedak padi dengan konsentrasi 20% menunjukkan hasil paling baik, yaitu 0,97 cm/hari untuk laju pertumbuhan miselium dan 0,885 kg untuk bobot tubuh buah jamur tiram coklat, dengan kepadatan miselium tebal dan memenuhi medium tanam, serta pH medium tanam sebesar 6,8.
Kata kunci: Pleurotus pulmonarius, jenis bahan tambahan, konsentrasi bahan tambahan, pertumbuhan miselium, bobot tubuh buah
SISTEM INFORMASI GEOGRAFIS (SIG) UNTUK PEMANTAUAN ANEMIA IBU HAMIL (STUDI DI DINAS KESEHATAN KABUPATEN (DKK) BREBES)
Authors: Nurhayati Siti 
Published: March 2023

A main task of Section of Founding Society’s Nutrient at the District Health Office of Brebes is to plan, to conduct, to develop a program of improving society’s nutrient and coping with nutrient problem. Anemia because of iron defeciency on the pregnancy woman is one of the nutrient problems in District of Brebes. The aim of research was to devolep an information system based on Geographical Information System (GIS) for monitoring anemia of pregnancy woman. This research had two steps. First step was a qualitative research that was used seven methodology steps of FAST development (Framework for the Application of System Techniques). Second step was a quantitave research using pre-exprmental one group posttest only/the one shot case study design. In this design, the treatment that had been done was measured and observed (pottest). Data of observation was analyzed by a descriptive method using a considered average. Subjects were the head of the district health office of Brebes, the head of sub-departement of the public health empowerment, the head of section, and the staffs of section of founding society’s nutrient. Information system has overall considered average equal to 4,05. It means that user generally has apporved it. The considered average for accessibility, completeness of information,relevancy, and speed is equal to 4, for ease is equal to 4,25, and for management of data basis is equal to 4,08. It means that accessibilty, completeness of information, revalancy, speed, ease, and management of data basis for an information system that has been devoleped, is approved by respondent and has a good value.