bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Integration of Exoteric and Esoteric: Towards a More Holistic Islamic Practice
Authors: Ab Majid Arfah 
Published: March 2023

Abstract: In recent years, Malaysian Muslims seem to have experienced an upsurge in religious awareness and practices. The increasing religious trends could be seen from the mode of dressing especially among the Muslim women such as the wearing of hijab and niqab; the use of Arabic words to replace the Malay words in daily conversation and greeting such as solat to replace sembahyang, iftar to replace buka puasa and Eid Mubarak to replace Selamat Hari Raya and the mushrooming of religious programs and events such as World #QuranHour and Malam Cinta Rasul. Unfortunately, despite these inspiring Islamic awareness and practices, issues related to morality, crimes, discrimination, corruption and other unethical conducts associated with the Muslims are also on the rise. This is due to the fact that what seems to have increased are only the exoteric dimension of the religion i.e. the exterior rules, regulations and visible practices, not the esoteric part i.e. the interiority and the spirituality. This paper aims at exploring the phenomenon of the pervasiveness of the exoteric aspect of religion compared to the esoteric aspect and assessing the consequences of the imbalance between these two dimensions. The expression of exoteric dimensions solely without the cultivation of the esoteric part has rendered bad impression and misinterpretation of the true Islamic teaching. A holistic Islamic practice that encompasses both exoteric and esoteric dimensions is essential for producing the best ummah.

Abstrak: Dalam beberapa tahun kebelakangan ini, umat Islam Malaysia nampaknya telah mengalami peningkatan dalam kesedaran dan amalan agama. Tren keagamaan yang semakin meningkat dapat dilihat daripada cara berpakaian khususnya di kalangan wanita Islam seperti pemakaian tudung dan niqab; penggunaan perkataan Arab bagi menggantikan perkataan Melayu dalam percakapan dan sapaan harian seperti solat menggantikan sembahyang, iftar menggantikan berbuka puasa dan Eid Mubarak menggantikan Selamat Hari Raya serta peningkatan program dan acara keagamaan seperti World #QuranHour dan Malam Cinta Rasul. Malangnya, di sebalik kesedaran dan amalan Islam yang memberi inspirasi ini, isu-isu berkaitan moral, jenayah, diskriminasi, rasuah dan kelakuan tidak beretika lain yang dikaitkan dengan umat Islam juga semakin meningkat. Ini disebabkan oleh hakikat bahawa apa yang kelihatan meningkat hanyalah dimensi eksoterik agama iaitu peraturan luaran, undang-undang dan amalan yang boleh dilihat, bukan bahagian esoterik iaitu dalaman dan kerohanian. Kertas kerja ini bertujuan untuk meneroka fenomena keluasan aspek eksoterik agama berbanding aspek esoterik dan menilai akibat ketidakseimbangan antara kedua-dua dimensi ini. Ekspresi dimensi eksoterik semata-mata tanpa penyemaian dimensi esoterik telah memberikan tanggapan buruk dan salah tafsiran terhadap ajaran Islam yang sebenar. Amalan Islam holistik yang merangkumi kedua-dua dimensi eksoterik dan esoterik adalah penting untuk melahirkan ummah yang terbaik.
Did Rural Micro-Entrepreneurs Do Make A Higher Gain? A Preliminary Study on The Potential of Supply Chain Digitalization Using PLS-SEM Approach
Authors: Ahmad Rosli Muhammad Syahrul Deen , Mat Rani Mohd Afandi , Tumiran Mohd Amzari , Mohd Arif Mohd Izzat Amsyar 
Published: March 2023

Studies on digitalization disruption and its impact on business are gaining global attention, especially among small and medium entrepreneurs (SMEs). It is theoretically expected to be a business value add element in terms of capability and competitiveness in the supply chain ecosystem, which is fundamental in business success. But digitalization also has its own risks and challenges including expertise, capital, cooperation, incentives, and support from other economic units, such as other merchants and customer preferences. Failure in digitization can lead to mistrust and negative perceptions that may lead to effects the SME growth. Among the biggest digitalization challenges are for the rural micro-entrepreneurs (RME) who live in areas that lack digital support facilities and technological capabilities, such as a weak internet connection and native customer's desire to buy using online shopping platforms. This study will analyze the competitive level of RME businesses from a supply chain perspective. To analyze the impact of supply chain digitization (DSC), a mediator effect will be used. DSC will be applied in mediator effect to entrepreneurial supply chain towards the level of RME’s business competitiveness. The hypothesis of this study is DSC practice has a role on the growth of RME business competitiveness. Using the Partial Lease Square-Structural Equation Modeling (PLS-SEM) method, this study found that RMC’s efforts on business digitization do not have a significant impact on the development of business competitiveness. The hypothesis of this study was confirmed by the rate of P-value. While DSC mediator effect through variance accounted for (VAF) calculation found that there is low partial mediation (23%). This paper proposes a further study on the elements of competitiveness and the desire for digitalization of RMC to be investigated, while the current need for a comprehensive DSC model of RMC particularly, in line with rural economic development issues in Malaysia.
Tadbir Urus Islam di Darul Quran: Satu Kerangka Konsep dalam Pendidikan Tahfiz
Authors: Abdul Ghani Azmi Ilhaamie , Muhamad Asmawati , Tengku Kasim Tengku Sarina , Ab Halim Asyiqin 
Published: March 2023

Pendidikan tahfiz merupakan salah sebuah sektor yang semakin bertapak kukuh dalam arus perdana pendidikan masa kini. Demi menyahut permintaan masyarakat yang mahukan anak mereka menghafal al-Quran, pendidikan tahfiz berkembang pesat ibarat cendawan tumbuh selepas hujan. Namun begitu, timbul beberapa isu mengenai kelemahan pendidikan tahfiz seperti keselamatan bangunan dan infrastruktur serta masalah sosial yang mana rakyat menyabitkannya dengan tadbir urus yang lemah. Tidak banyak perbincangan akademik yang menyentuh struktur tadbir urus Islam dalam pendidikan tahfiz terutamanya di peringkat persekutuan. Sehubungan itu, artikel ini cuba untuk menyediakan kerangka konsep tadbir urus Islam dalam pendidikan tahfiz terutamanya di Darul Quran. Dengan menggunakan kaedah perpustakaan, perkembangan Darul Quran dalam pendidikan tahfiz dan konsep tadbir urus dalam pendidikan tahfiz di peringkat persekutuan iaitu Darul Quran akan dikupas dalam artikel ini. Kerangka konsep pendidikan tahfiz di peringkat persekutuan juga dibangunkan di mana teori paradigm Tauhid dan Maqasid Syariah mendasari kerangka konsep ini.
Insights into the catalytic mechanism of the chlorothalonil dehalogenase from Pseudomonas sp. CTN-3
Authors: Yang Xinhang , Diviesti Karla , Miller Callie , Bennett Brian , Holz Richard C. 
Published: March 2023

The catalytically competent Co(II)-loaded form of the chlorothalonil dehalogenase from Pseudomonas sp. CTN-3 (Chd, EC 3.8.1.2) was characterized by kinetic and spectroscopic methods. Maximum chlorothalonil (TPN; 2,4,5,6-tetrachloroisophtalonitrile) dehalogenase activity was observed in the presence of one Co(II) ion per monomer with kcat and Km values of 12 ± 3 s−1 and 130 ± 10 μM, respectively, providing a catalytic efficiency (kcat/Km) of ∼9.2 × 104 M−1s−1. The dissociation constant (Kd) for Co(II) was determined to be 0.29 µM, and UV-Vis spectroscopy indicated the active site Co(II) ion resides in a penta-coordinate environment. EPR spectra of Co1-Chd contain at least three distinct signals, an MS = ± 1/2 signal with a ∼94 G 59Co hyperfine pattern centered at g1’ ≅ 6.7, a broader MS = ± 1/2 signal with g1’ ≅ 5.7, an MS = ± 3/2 signal with tentatively estimated parameters of g1’ ≅ 10.5 (gz = 2.75), A1(59Co) ≅ 110 G, and a high-field broad resonance at g3’ ≅ 1.8. Four substrate-analog inhibitors with IC50 values ranging from 110 μM to 19 mM were also identified and characterized. Upon the addition of each of the substrate-like inhibitors to Co1-Chd, changes in the EPR spectrum were observed that, in all cases, were simpler than that of Co1-Chd in the absence of inhibitors and could be simulated as either a single species or a mixture of two. Simulation of these data indicate that the corresponding EPR signals are each due to a ground state MS = 1/2 Kramers’ doublet and are consistent with pentacoordinate Co(II) with a relatively constrained coordination sphere. These data suggest that the nitrile moiety of TPN may not directly coordinate to the active site metal ion, providing new insight into the catalytic mechanism for Chd.
Correlation analysis between myocardial work indices and liver function classification in patients with hepatitis B cirrhosis: A study with non-invasive left ventricular pressure-strain loop
Authors: Cao Yang , Zhang Huihui , Li Shuai , Li Siliang , Sun Shuowen , Chen Jinwen , Ye Ting , Zhang Xijun , Yuan Jianjun 
Published: March 2023

BackgroundLiver cirrhosis is closely associated with cardiac dysfunction. The aims of this study were to evaluate left ventricular systolic function in patients with hepatitis B cirrhosis by non-invasive left ventricular pressure-strain loop (LVPSL) technique, and to explore the correlation between myocardial work indices and liver function classification.MethodsAccording to the Child-Pugh classification, 90 patients with hepatitis B cirrhosis were further divided into three groups: Child-Pugh A group (n = 32), Child-Pugh B group (n = 31), and Child-Pugh C group (n = 27). During the same period, 30 healthy volunteers were recruited as the control (CON) group. Myocardial work parameters, which included global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE), were derived from the LVPSL and compared among the four groups. The correlation between myocardial work parameters and Child-Pugh liver function classification was evaluated, and the independent risk factors affecting left ventricular myocardial work in patients with cirrhosis were investigated by univariable and multivariable linear regression analysis.ResultsGWI, GCW and GWE of Child-Pugh B and C groups were lower than those of CON group, while GWW was higher than that of CON group, and the changes were more obvious in Child-Pugh C group (P &lt; 0.05). Correlation analysis revealed that GWI, GCW, and GWE were negatively correlated with liver function classification to various degrees (r = −0.54, −0.57, and −0.83, respectively, all P &lt; 0.001), while GWW was positively correlated with liver function classification (r = 0.76, P &lt; 0.001). Multivariable linear regression analysis showed that GWE was positively correlated with ALB (β = 0.17, P &lt; 0.001), and negatively correlated with GLS (β = −0.24, P &lt; 0.001).ConclusionsThe changes in the left ventricular systolic function in patients with hepatitis B cirrhosis were identified using non-invasive LVPSL technology, and myocardial work parameters are significantly correlated with liver function classification. This technique may provide a new method for the evaluation of cardiac function in patients with cirrhosis.
Spatial-temporal distribution, metallogenic mechanisms and genetic types of nephrite jade deposits in China
Authors: Zhang Cun , Yang Fan , Yu Xiaoyan , Liu Jinhai , Carranza Emmanuel John M. , Chi Jie , Zhang Peng 
Published: March 2023

The nephrite jade deposits of different tectonic units in China exert significant commercial quality, which have attracted wide attention. However, these deposits have not been systematically summarized to date. Here, we investigate the major nephrite jade deposits in China to decipher their gemological and mineralogical characteristics, spatial-temporal distribution, and mineralization processes as well as to identify their geological settings and gemological properties, via integrating published geochronology, major and trace elements as well as H-O isotopes. The compiled data suggest that the major nephrite jade deposits in China can also be generally divided into green jade-type (GJ-type) and white jade-type (WJ-type) which covers different species, but most of them belong to the latter. The GJ-type nephrite deposits predominantly occur in ophiolite/ophiolitic mélange suites or are embedded into ultramafic serpentine jade orebodies. This type of nephrite jade mainly formed through the late auto-metamorphic metasomatism of serpentine or the spontaneous crystallization/precipitation along suture/shear zones that acted as pathways to migrate Ca-rich fluids during orogeny. In contrast, the orebodies of WJ-type nephrite jade are usually hosted at the contact zones between the dolomitic marbles and intermediate-felsic or mafic intrusive rocks, which were produced through metamorphism-metasomatism during post continent-continent collision, such as the Kunlun orogenic belt with about ∼1,300 km Hetian nephrite belt, and the eastern nephrite jade deposits along the Pacific Ocean. Our study highlights that the nephrite jade deposits in China originally formed during multiple tectonic stages related to the interactions between hydrothermal fluids and metamorphism under subduction accretion- and collision orogenesis-related settings. In addition, this study also provides insights into the genetic discrimination, mineral exploration, and occurrence characteristics of nephrite jade deposits as well as the evaluation and identification of nephrite jade quality.
Crack closure effect during the impact coal seam with high-pressure air blasting and the influence of gas drainage efficiency
Authors: Song Weihua , Jiao Huice , Wang Yingwei 
Published: March 2023

The crack closure in impact coal seams induced by high-pressure air blasting greatly affects gas drainage efficiency. The length of the crack closure was calculated and analyzed based on energy and elastic theories. The closure region was then determined to be 3.8 m from the blasting hole. The results of a high-pressure air blasting experiment in the underground of one coal mine in China showed that the effect of crack closure on gas drainage efficiency manifested as a decreased amplitude of gas emission in the crack closure region. At 1.0–4.0 m from the blasting hole, the amplitude of gas emission in the observation holes first increased and then decreased with increasing distance from the blasting hole. At 1.8–2.5 m from the blasting hole, the amplitude of the gas emission was maximal. At 4.0 m from the blasting hole, the crack was nearly closed, and the gas emission in the observation holes was minimal. The theoretical calculation had good consistency with the field test results; thus, it can provide an important reference for an appropriate arrangement of gas drainage boreholes.
The deformation evolution law and stability evaluation of the high-filled slope in the cutting hills to backfill ditches project
Authors: Hu Jun , Yuan Wei , Fu Xiaodong , Zhang Zhenping , Zhou Yongqiang , Chai Shaobo , Cheng Yongliang , Sheng Qian 
Published: March 2023

The cutting hills to back ditches (CHBD) project has been widely implemented since urbanization in hilly areas is steadily rising. The stability of the high-filled slope and the problem of foundation settlement deformation has become one of the vital issues for safe construction. This paper focused on the deformation evolution law and stability assessment of the high-filled deposit slope composed of the soil-rock mixture (S-RM) in the CHBD project, in Shiyan City, Hubei Province as examples. First, large-scale direct shear tests of S-RM with different rock block proportions (RBPs) under different various normal stresses were carried out, and its mechanical properties were analyzed. Next, the finite element method was used to simulate the processes of the step-by-step filling, and the deformation evolution law was analyzed. Then, the limited equilibrium method (LEM) was used to obtain the potential sliding surfaces and the corresponding safety factors of the high-filled slope, and the safety of the construction was assessed. Finally, automated monitoring of the step-by-step settlement and deep soil deformation was computerized for the typical locations, and the long-term stability of the high-filled slope was studied. The results demonstrate that the first layer of backfill in the F area contains the largest incremental settlement displacement in the y-direction, whereas the value in the G area occurs at the site of the fill layer close to the slope surface at each filling timestep. The displacement response value steadily declines with the increasing filling depth and horizontal displacement, presenting a clear spatial influence range, with the site of maximum incremental displacement as the center. After filling, the safety factors of the potential sliding surface in the F and G areas are 2.531 and 1.118, respectively, and the slope is in a stable state. The monitoring data show that the deformation mostly takes place within 10 m of the surface. The study’s findings are thought to offer technical and practical knowledge for the slope risks.
Strategies involving low-molecular-weight heparin for the treatment and prevention of venous thromboembolism in patients with obesity: A systematic review and meta-analysis
Authors: Liu Junjie , Qiao Xi , Wu Mingdong , Wang Haiyang , Luo Hailong , Zhang Haolong , Chen Yikuan , Sun Jianming , Tang Bo 
Published: March 2023

IntroductionRecent studies have indicated that the dosage of LMWH in patients with specific weights may be controversial. Therefore, we conducted a meta-analysis to explore an appropriate dosage of LMWH for the prevention and treatment of venous thromboembolism (VTE) in patients with obesity.Materials and methodsWe searched the PubMed, EMBASE, and Cochrane Library databases up to July 23, 2022. Study selection, bias analysis, and information extraction were performed by three independent reviewers. The occurrence or recurrence of VTE and bleeding events were the primary outcomes we assessed.ResultsEleven studies (a total of 6266 patients) were included in the prevention group, and 6 studies (a total of 3225 patients) were included in the treatment group. For VTE prophylaxis, compared with the standard-dosage group, the high-dosage group had a lower incidence of VTE (OR: 0.47, 95% CI: 0.27-0.82, P=0.007) and a similar incidence of bleeding events (OR: 0.86, 95% CI: 0.69-1.08, P=0.020). For VTE therapy, compared to the standard-dosage group, the reduced-dosage group had a similar incidence of VTE recurrence (OR: 0.86, 95% CI: 0.11-6.84, P=0.89) but a lower incidence of bleeding events (OR: 0.30, 95% CI: 0.10-0.89, P=0.03).ConclusionIn patients with obesity, increasing the dosage of LMWH is a more appropriate option for the prevention of VTE. Due to the limited evidence, reducing the therapeutic dosage of LMWH requires careful consideration. Larger-scale, well-designed randomized controlled trials are necessary.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?, identifier ID=CRD42022298128.
A bi-directional Mendelian randomization study of sarcopenia-related traits and type 2 diabetes mellitus
Authors: Chen Simin , Yan Shikang , Aiheti Nuerbiyamu , Kuribanjiang Kaidiriyan , Yao Xuemei , Wang Qian , Zhou Tao , Yang Lei 
Published: March 2023

BackgroundPrevious studies have reported an association between sarcopenia and type 2 diabetes mellitus (T2DM), but causation was prone to confounding factors. A more robust research approach is urgently required to investigate the causal relationship between sarcopenia and T2DM.MethodsThe bi-directional two-sample MR study was carried out in two stages: Sarcopenia-related traits were investigated as exposure while T2DM was investigated as an outcome in the first step, whereas the second step was reversed. The GWAS summary data for hand-grip strength (n = 256,523), appendicular lean mass (ALM, n = 450,243), and walking pace (n = 459,915) were obtained from the UK Biobank. T2DM data were obtained from one of the biggest case-control studies on diabetes (DIAGRAM; n = 180,834 cases and 492,191 controls), which was published in 2022. The inverse-variance weighted (IVW) approach was used to obtain MR estimates, and various sensitivity analysis was also performed.ResultsLow hand-grip strength had a potential causal relationship with an increased incidence of T2DM (OR = 1.109; 95% CI, 1.008–1.222; p = 0.0350). T2DM risk was reduced by increasing ALM and walking pace: A 1 kg/m2 increase in ALM decreased the risk of T2DM by 10.2% (OR = 0.898; 95% CI, 0.830–0.952; p &lt; 0.001). A 1 m/s increase in walking pace decreased the risk of T2DM by 90.0% (OR = 0.100; 95% CI, 0.053–0.186; p &lt; 0.001). The relationship was bidirectional, with T2DM as a causative factor of sarcopenia-related traits (p &lt; 0.05) except for ALM (β = 0.018; 95% CI, −0.008 to −0.044; p = 0.168).ConclusionsHand-grip strength and T2DM had a potential bidirectional causal relationship, as did walking pace and T2DM. We suggest that sarcopenia and T2DM may mutually have a significant causal effect on each other.
Causal relationship between thyroid dysfunction and hallux valgus: A two-sample Mendelian randomization study
Authors: Xiong Binglang , Bai Zixing , Cao Xuhan , Nie Duorui , Zhang Cheng , Sun Xudong , Guo Ziyan , Wen Jianmin , Sun Weidong 
Published: March 2023

IntroductionPrevious observational studies have reported that thyroid dysfunction is associated with hallux valgus (HV). However, the causal effect of thyroid dysfunction on hallux valgus is still unknown. To assess whether there is a causal relationship between thyroid dysfunction and hallux valgus, we performed a two-sample Mendelian randomization (MR) study.MethodsThe data of the two-sample Mendelian randomization study were obtained from public databases. In this study, hypothyroidism, hyperthyroidism, free thyroxine (FT4), and thyrotropin (TSH) were chosen as exposures. The single nucleotide polymorphisms (SNP) of hypothyroidism and hyperthyroidism were from the genome-wide association studies (GWAS) of the IEU database, including 337,159 subjects. Data for FT4 and TSH (72,167 subjects) were extracted from the ThyroidOmics Consortium. HV was used as the outcome. The SNPs associated with HV were selected from a GWAS of 202,617 individuals in the fignngen database. The inverse variance weighted (IVW) method was used as the primary analysis. Four complementary methods were applied, including MR-presso, MR-Egger, and weighted median. In addition, Cochran’s Q test, MR-presso, MR-Egger regression, and the leave-one-out test were used as sensitivity analysis, and the MR-pleiotropy test was performed to examine pleiotropy.ResultsAccording to the results of IVW, we found that there was a causal relationship between hypothyroidism and HV, and hypothyroidism increased the incidence of HV (OR = 2.838 (95% CI: 1.116–7.213); p = 0.028). There were no significant causal effects of hyperthyroidism, FT4, and TSH on HV (p &gt; 0.05). Sensitivity analyses showed that the results were robust and reliable, and no horizontal pleiotropy was detected.ConclusionsOur findings provided genetic support that hypothyroidism might increase the risk of HV. It will predict the occurrence of HV in patients with hypothyroidism and provide suggestions for early prevention and intervention.