bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hodological organization of spoken language production and singing in the human brain
Authors: Pitkäniemi Anni , Särkämö Teppo , Siponkoski Sini-Tuuli , Brownsett Sonia L. E. , Copland David A. , Sairanen Viljami , Sihvonen Aleksi J. 
Published: July 2023

AbstractTheories expounding the neural relationship between speech and singing range from sharing neural circuitry, to relying on opposite hemispheres. Yet, hodological studies exploring their shared and distinct neural networks remain scarce. In this study, we combine a white matter connectometry approach together with comprehensive and naturalistic appraisal of verbal expression during spoken language production and singing in a sample of individuals with post-stroke aphasia. Our results reveal that both spoken language production and singing are mainly supported by the left hemisphere language network and projection pathways. However, while spoken language production mostly engaged dorsal and ventral streams of speech processing, singing was associated primarily with the left ventral stream. These findings provide evidence that speech and singing share core neuronal circuitry within the left hemisphere, while distinct ventral stream contributions explain frequently observed dissociations in aphasia. Moreover, the results suggest prerequisite biomarkers for successful singing-based therapeutic interventions.
Effect of Healthy Aging and Gender on Syntactic Input Processing: A P600 Event-Related Potential Study
Authors: Dorme Annelien , Van Oudenhove Bram , Criel Yana , Depuydt Emma , De Groote Evelien , Stalpaert Jara , Huysman Eline , van Mierlo Pieter , De Letter Miet 
Published: July 2023

Purpose:
This study aimed to investigate the effect of healthy aging and gender, as well as the interaction, thereof, on syntactic input processing during sentence comprehension. This was achieved through the recording of the P600 event-related potential.

Method:
Sixty Flemish (native speakers of Dutch) participants (30 men and 30 women), equally distributed into three age groups (young, middle-aged, and older adults), were subjected to a visually presented word order violation task under simultaneous electro-encephalography recording. The task contained 60 sentences, of which half were grammatical and half contained a word order violation. P600 responses were analyzed for amplitude, latency, topographical distribution, and source localization.

Results:
Regarding the effect of healthy aging, no age-related differences were found for the amplitude, onset latency, and topographical distribution of the P600 effect (difference wave). Although aging effects on the P600 effect amplitude were absent, a reduced P600 amplitude in response to both the grammatical and ungrammatical sentences was found, next to a reduced overall degree of source activation in linguistic regions of interest. Also, a reduced behavioral accuracy in response to the word order violation was observed in the older adults group. Regarding the effect of gender, females exhibited a larger P600 effect amplitude and a reduced behavioral accuracy compared to males. No gender-related differences were found for P600 effect onset latency, topographical distribution, and source activation.

Conclusions:
While this study demonstrates no effect of aging on the P600 effect, the lower behavioral response and absence of any activation shift argues against functional compensation. Moreover, although increased neural activation in women combined with their reduced behavioral accuracy may indicate the use of different cognitive strategies in men and women, source localization analysis could not objectify this hypothesis.
New measurement method of displacement susceptibility based on time‐domain current and potential combined spectra
Authors: Han Yongsen , Suo Changyou , Peng Cheng , Li Zhonghua 
Published: July 2023

AbstractDisplacement susceptibility is a very important parameter to characterise the displacement polarisation of dielectrics. Two methods based on the time‐domain current and potential combined spectra are proposed to measure the displacement susceptibility. One is based on the time‐domain polarisation current and decay potential combined spectra, and the other is based on the time‐domain depolarisation current and recovery potential combined spectra. The principle of the proposed methods are verified by simulation. In addition, a measurement system for the two proposed methods is built and is used to measure the displacement susceptibility of transparent organic glass and opaque nonlinear field grading materials. The experimental results are compared with those of the present optical method and the frequency‐domain method. Simulation and experimental results show that the proposed methods for the measurement of displacement susceptibility are feasible and practical, which lays a foundation for the research on the polarisation characterisation of dielectrics.
Still alive and kicking: A significant outburst in changing-look AGN Mrk 1018
Authors: Brogan R. , Krumpe M. , Homan D. , Urrutia T. , Granzer T. , Husemann B. , Neumann J. , Gaspari M. , Vaughan S. P. , Croom S. M. , Combes F. , Pérez Torres M. , Coil A. , McElroy R. , Winkel N. , Singha M. 
Published: July 2023

Context. Changing-look active galactic nuclei (AGN) have been observed to change their optical spectral type. Mrk 1018 is particularly unique: first classified as a type 1.9 Seyfert galaxy, it transitioned to being a type 1 Seyfert galaxy a few years later before returning to its initial classification as a type 1.9 Seyfert galaxy after ∼30 years.
Aims. We present the results of a high-cadence optical monitoring programme that caught a major outburst in 2020. Due to sunblock, only the decline could be observed for ∼200 days. We studied X-ray, UV, optical, and infrared data before and after the outburst to investigate the responses of the AGN structures.
Methods. We derived a u′-band light curve of the AGN contribution alone. The flux increased by a factor of ∼13. We confirmed this in other optical bands and determined the shape and speed of the decline in each waveband. The shapes of Hβ and Hα were analysed before and after the event. Two XMM-Newton observations (X-ray and UV) from before and after the outburst were also exploited.
Results. The outburst is asymmetric, with a swifter rise than decline. The decline is best fit by a linear function, ruling out a tidal disruption event. The optical spectrum shows no change approximately eight months before and 17 months after. The UV flux is increased slightly after the outburst but the X-ray primary flux is unchanged. However, the 6.4 keV iron line has doubled in strength. Infrared data taken 13 days after the observed optical peak already show an increased emission level as well.
Conclusions. Calculating the distance of the broad-line region and inner edge of the torus from the supermassive black hole can explain the multi-wavelength response to the outburst, in particular: i) the unchanged Hβ and Hα lines, ii) the unchanged primary X-ray spectral components, iii) the rapid and extended infrared response, as well as iv) the enhanced emission of the reflected 6.4 keV line. The outburst was due to a dramatic and short-lasting change in the intrinsic accretion rate. We discuss different models as potential causes.
Energy-resolved pulse profiles of accreting pulsars: Diagnostic tools for spectral features
Authors: Ferrigno Carlo , D’Aì Antonino , Ambrosi Elena 
Published: July 2023

Aims. We introduce a method for extracting spectral information from energy-resolved light curves folded at the neutron star spin period (known as pulse profiles) in accreting X-ray binaries. Spectra of these sources are sometimes characterized by features superimposed on a smooth continuum, such as iron emission lines and cyclotron resonant scattering features. We address here the question on how to derive quantitative constraints on such features from energy-dependent changes in the pulse profiles.
Methods. We developed a robust method for determining in each energy-selected bin the value of the pulsed fraction using the fast Fourier transform opportunely truncated at the number of harmonics needed to satisfactorily describe the actual profile. We determined the uncertainty on this value by sampling through Monte Carlo simulations a total of 1000 faked profiles. We rebinned the energy-resolved pulse profiles to have a constant minimum signal-to-noise ratio throughout the whole energy band. Finally we characterize the dependence of the energy-resolved pulsed fraction using a phenomenological polynomial model and search for features corresponding to spectral signatures of iron emission or cyclotron lines using Gaussian line profiles.
Results. We apply our method to a representative sample of NuSTAR observations of well-known accreting X-ray pulsars. We show that, with this method, it is possible to characterize the pulsed fraction spectra, and to constrain the position and widths of such features with a precision comparable with the spectral results. We also explore how harmonic decomposition, correlation, and lag spectra might be used as additional probes for detection and characterization of such features.
Proprietários florestais. Lógicas, dinâmicas e coordenação na gestão dos espaços florestais
Authors: Canadas Maria João , Novais Ana , Reis Pedro , Santos José L. , Baptista Fernando O. 
Published: July 2023

A identificação das práticas de gestão dos espaços florestais pelos seus proprietários é fundamental para compreender a evolução das funções ambientais e socioeconómicas desses mesmos espaços.
Dos resultados de um conjunto de inquéritos a proprietários florestais, realizados em diferentes momentos e regiões, privilegiamos três vertentes de análise: a resposta de gestão dos proprietários ao risco de incêndio; a mudança e diversidade de práticas de gestão de eucaliptais; e a disponibilidade dos proprietários para a coordenação da gestão à escala da paisagem.
Nas conclusões destacamos, em primeiro, que a não realização de intervenções de redução de combustível não é sinónimo de não gestão ou abandono, e pode corresponder a uma estratégia de minimização do risco económico, quando o rendimento expectável não cobre o custo dessas intervenções. Em segundo, a alteração das condições gerais de produção e o aumento da diversidade dos povoamentos de eucalipto, que acompanhou a expansão de área, favorece a diferenciação da rentabilidade e o consequente aumento da carga combustível nas situações mais marginais. Por último, ainda que haja disponibilidade e até mobilização dos proprietários para a gestão coordenada, a sua implementação está dependente da continuidade de objetivos e apoios financeiros das políticas.
Effects of Muscle Energy Technique versus Shoulder Mobilization on Pain and Function in Patients with Subacromial Pain Syndrome
Authors: Ishaq Shahid , Dustgir Atif , Mehdi Zunaira , Mahmood Khalid , Fatima Rukhsar , Tasawer Muhammad Noman 
Published: July 2023

Abstract
Background Subacromial pain syndrome is most leading cause of disability that includes the wide spectrum of disorders including subacromial tendinopathy, partial or full thickness tear of rotator cuff and subacromial bursitis. The manual therapy interventions for this condition are still debatable.
Aim To evaluate the comparative effects of muscle energy technique (MET) versus posterior shoulder mobilization with movement (MWM) on pain, function and shoulder range of motion in patients with subacromial pain syndrome.
Method Patients diagnosed with subacromial pain syndrome were recruited in this pragmatic parallel double blinded randomized clinical trial. The sample was selected through non-probability convenient sampling technique. Forty patients out of 56 meeting the eligibility criteria were equally divided into two groups, MET group (n = 20) and MWM group (n = 20), through a randomization web service. Data were collected at baseline and after successful completion of a six week trial treatment. Pain severity was measured by using a numeric pain rating scale, shoulder disability was measured by using the Shoulder Pain and Disability Index (SPADI) and ranges of motion were measured by using goniometry. Data was analyzed through SPSS 24.
Results Outcome measures including pain, disability and shoulder range of motion were significantly (p ≤ 0.05) improved in both groups after the intervention. When comparing both groups, pain score was U = 82.0 (p ≤ 0.001) and disability score was t = –2.913 (p ≤ 0.006) favoring MET.
Conclusion Both MET and MWM were effective for symptomatic management in this sample of 40 patients with subacromial impingement syndrome. MET seems to show some superior effects as compared to MWM.
Ursachen und Management von IOL-Dislokationen
Authors: Khoramnia Ramin , Baur Isabella Diana , Auffarth Gerd U. 
Published: July 2023

ZusammenfassungDie frühe (< 3 Monate) IOL-Dislokation tritt aufgrund einer unzureichenden Fixation im Kapselsack auf, während die späte Dislokation (≥ 3 Monate) durch eine zunehmende Insuffizienz des
Zonulaapparates begründet ist. Aktuell werden zur Aphakiekorrektur bei IOL-Tausch vor allem Irisfixierte IOL (IFIOL) und mittels Naht oder nahtlos fixierte sklerafixierte IOL (SFIOL)
eingesetzt. Es wurden verschiedene Methoden zur Sklerafixierung mit oder ohne Naht beschrieben. Die wichtigsten Techniken werden in dieser Arbeit zusammengefasst. IFIOL und SFIOL ermöglichen
vergleichbare Visusergebnisse, unterscheiden sich aber in ihrem Risikoprofil. Die Entscheidung, welche Methode zum Einsatz kommt, hängt u. a. auch von den Gegebenheiten im jeweiligen Fall
und der Präferenz des Operateurs ab.
Natural History of Non-Functioning Pituitary Adenomas: A Systematic
Review and Meta-Analysis
Authors: Rikvold Stefan Dukanovic , Pedersen Mathias Brown , Andreassen Mikkel , Krogh Jesper 
Published: July 2023

AbstractThe management of non-functioning pituitary tumors (NFPTs) relies on the risk of
tumor growth and new endocrinopathies. The objective of this systematic review
was to assess the risk of growth, new pituitary endocrinopathies, and surgery in
patients with conservatively treated NFPTs. We conducted a bibliographical
search identifying studies assessing NFPTs followed conservatively. Estimates
were pooled using random-effects meta-analysis reporting events per 100 person
years (PYs), in case of high heterogeneity (I2>75%) only the
range of observed effects was reported. We identified 30 cohort studies
including 1957 patients with a mean follow-up time of 4.0 (SD 1.5) years. The
overall risk of tumor growth ranged from 0.0 to 14.2/100 PYs
(I2=90%), while the overall risk of new endocrinopathies was
0.9/100 PYs (95% CI. 0.5 to 1.2; I2=35%)
and risk of surgery ranged from 0.0 to 7.7/100 PYs
(I2=80%). Compared to microadenomas, macroadenomas had
higher risk of growth (p=0.002), higher risk of surgery
(p=0.006), and non-significant differences in risk of new
endocrinopathies (p=0.15). An analysis of microadenomas found the
risk of growth to be 1.8/100 PYs (95% CI. 0.9 to 2.8;
I2=58%), the risk of new endocrinopathies
0.7/100 PYs (95% CI. 0.0 to 1.6; I2=37%)
and the risk of surgery 0.5/100 PYs (0.1 to 0.9;
I2=37%). These data support individualized follow-up
strategies of patients with NFPTs and particularly a less rigorous follow-up of
patients with microadenomas.
Functional MR urography in children – update 2023
Authors: Kirsch Hanne , Krüger Paul-Christian , John-Kroegel Ulrike , Waginger Matthias , Mentzel Hans-Joachim 
Published: July 2023

Background Functional MR urography (fMRU) has developed into an innovative, radiation-free option for assessing parameters of kidney function in pediatric radiology. The importance of fMRU in comparison to the standardized established nuclear medicine procedure (99mTc-Mercapto-acetyltriglycerine, MAG3 scintigraphy) is shown using SWOT analysis.
Methods To assess the current state of research, a selective literature search was carried out in PubMed. Taking into account the current scientific status, the examination technique, preparation, and evaluation of fMRU are presented.
Results As a result of the comparison with MAG3, fMRU is suitable for certain indications and represents an optimal combination of morphological and functional representation of the kidneys and urinary tract, especially in the case of surgical consequences.
Conclusion fMRU has been successfully established as a diagnostic method for assessing the morphology and function of the kidneys in competition with MAG3 scintigraphy.
Key Points
Citation Format
Aberrantly Expressed lncRNA LINC00847 May Serve as a Promising
Prognostic Factor for Thyroid Cancer
Authors: Hei Guoli , Yu Yan , Wu Yang , Huang Jianyuan 
Published: July 2023

AbstractThyroid cancer is a tumor that occurs in the head and neck, which originates from
the thyroid follicular epithelial cells. The current research is discussed and
elaborated from the perspective of molecular prognostic biomarkers to gain a
deeper understanding of the molecular mechanism of thyroid cancer and to provide
more effective treatment and prognostic methods for patients. Thyroid cancer
patients were explored from histological, cellular and clinical levels.
Real-time quantitative polymerase chain reaction (RT-qPCR) was used to detect
the expression of LINC00847 and miR-146b-5p in the tissues and cells of the
subjects. Cell growth and thyroid cancer progression were determined by the cell
counting kit-8 (CCK-8) and transwell assays. The LINC00847 sponge miR-146b-5p
was assessed by bioinformatics tools and luciferase reporter assay, and the
Kaplan–Meier method and multivariate Cox regression analysis suggested
the prognostic value of high expression of LINC00847. In thyroid cancer tissues
and cells, the expression of LINC00847 was decreased. Overexpression of
LINC00847 remarkably inhibited the proliferation level, migration ability and
invasion ability of thyroid cancer cells. Besides, miR-146b-5p was upregulated
in thyroid cancer tissues and cells. It was confirmed that LINC00847 targeting
miR-146b-5p had a regulatory effect on the progression of thyroid cancer, and
LINC00847 was negatively correlated with miR-146b-5p. LINC00847 may be
considered a meaningful prognostic marker to influence tumor growth through
sponge miR-146b-5p, which provides a new basis for the prognosis and treatment
of thyroid cancer.
Cervical myelitis: a practical approach to its differential diagnosis on MR imaging
Authors: Weidauer Stefan , Hattingen Elke , Arendt Christophe Théo 
Published: July 2023

Background Differential diagnosis of non-compressive cervical myelopathy encompasses a broad spectrum of inflammatory, infectious, vascular, neoplastic, neurodegenerative, and metabolic etiologies. Although the speed of symptom onset and clinical course seem to be specific for certain neurological diseases, lesion pattern on MR imaging is a key player to confirm diagnostic considerations.
Methods The differentiation between acute complete transverse myelitis and acute partial transverse myelitis makes it possible to distinguish between certain entities, with the latter often being the onset of multiple sclerosis. Typical medullary MRI lesion patterns include a) longitudinal extensive transverse myelitis, b) short-range ovoid and peripheral lesions, c) polio-like appearance with involvement of the anterior horns, and d) granulomatous nodular enhancement prototypes.
Results and Conclusion Cerebrospinal fluid analysis, blood culture tests, and autoimmune antibody testing are crucial for the correct interpretation of imaging findings. The combination of neuroradiological features and neurological and laboratory findings including cerebrospinal fluid analysis improves diagnostic accuracy.
Key Points:
Enamine N-Oxides: Design, Synthesis, and Function in Bioortho­gonal Reactions
Authors: Kim Justin , Kang Dahye 
Published: July 2023

AbstractEnamine N-oxides act as a chemical linchpin bridging two bioorthogonal associative and dissociative reactions. This article describes the design of enamine N-oxides, their synthesis through the retro-Cope elimination reaction, the use of solvent, hyperconjugation, strain, and rehybridization effects to achieve bioorthogonal reactivity, and their rapid reductive cleavage with diboron reagents. The coordinated assembly and disassembly of the enamine N-oxide motif constitutes a powerful chemical operation that enables the attachment and detachment of small molecules from biomacromolecules in a biological setting.1	Introduction2	Background3	General Access to Linear Enamine N-Oxides4	Strain-Promoted Hydroamination Reaction5	Electronically Activated Alkynes6	Chemically Revertible Reactions7	Conclusion
Practical Asymmetric Synthesis of Sulfoximines and Sulfimides from Sulfinamides
Authors: Kano Taichi , Tsuzuki Saori 
Published: July 2023

AbstractChiral sulfoximines and sulfimides are an interesting class of compounds in various areas. However, methodologies for preparing these chiral sulfur compounds in a stereoselective manner have been underdeveloped. Herein, we briefly summarize our recent studies on asymmetric synthesis of sulfoximines and sulfimides from readily available enantioenriched sulfinamides. In these studies, optically pure sulfoximines and sulfimides having various carbon substituents on their sulfur atom could be obtained.1	Introduction2	Asymmetric Synthesis of Chiral Sulfoximines3	Asymmetric Synthesis of Chiral Sulfimides4	Conclusion
Current Patterns of Probiotic Use in U.S. Neonatal Intensive Care Units: A Multi-Institution Survey
Authors: Hanna Morcos , Ahmad Irfan , Yanowitz Toby , Kim Jae , Hunter Catherine , DiGeronimo Robert , Ahmad Kaashif A. , Sullivan Kevin , Markel Troy A. , Hair Amy B. , Chaaban Hala , Pammi Mohan , Huff Katie A. , Jasani Bonny , Fuchs Lynn , Cuna Alain , Garg Parvesh M. , Reber Kristina , Premkumar Muralidhar H. ,   On behalf of the Children's Hospital Neonatal Consortium Necrotizing Enterocolitis Focus Group
Published: July 2023

Objective Probiotic supplementation is associated with health benefits in preterm infants. The 2021 American Academy of Pediatrics (AAP) statement on probiotic use advised caution, citing heterogeneity and absence of federal regulation. We assessed the impact of the AAP statement and current institution-wide patterns of probiotic use across neonatal intensive care units (NICU) across the United States.
Study Design A cross-sectional web-based institutional survey using REDCap was emailed to 430 Children's Hospital Neonatal Consortium (CHNC) and Pediatrix Medical Group institutions. The survey captured data on probiotic formulations, supplementation, initiation and cessation criteria, reasons for discontinuation, interest in initiating, and AAP statement's impact.
Results Ninety-five (22.1%) hospitals, including 42/46 (91%) CHNC and 53/384 (14%) Pediatrix institutions, completed the survey. Thirty-seven (39%) currently use probiotics. Fourteen different probiotic formulations were reported. The common criteria for initiation were birth weight <1,500 g and gestational age <32 weeks. Parental consent or assent was obtained at only 30% of institutions. Five hospitals (11%) with prior probiotic use discontinued solely due to the AAP statement. Overall, 23 (24%) of hospitals indicated that the AAP statement significantly influenced their decision regarding probiotic use. Nineteen of 51 nonusers (37%) are considering initiation.
Conclusion Probiotic use in preterm infants is likely increasing in NICUs across the United States, but significant variability exists. The 2021 AAP statement had variable impact on NICUs' decision regarding probiotic use. The growing interest in adopting probiotics and the significant interhospital variability highlight the need for better regulation and consensus guidelines to ensure standardized use.
Key Points