bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sea grapes (Caulerpa lentillifera J. Agardh, Chlorophyta) for human use: Structured review on recent research in cultivation, nutritional value, and post-harvest management
Authors: Stuthmann Lara Elisabeth , Brix da Costa Beatrice , Springer Karin , Kunzmann Andreas 
Published: July 2023

AbstractSeaweeds are a major contributor to global marine aquaculture production, with the biomass being mainly used, among others, for human nutrition, pharmaceutics, and cosmetics. However, green seaweeds are severely underrepresented, compared to red and brown macroalgae. Caulerpa lentillifera (known as “sea grapes” or “green caviar”) is an edible, green seaweed with a distinctive texture and various nutritional benefits. In this review, all articles on sea grapes published between 1900 and October 2022 and found in the scientific citation databases Scopus and Web of Science (search string: “caulerpa” AND “lentillifera”) were grouped by research topic and the intended application following the PRISMA approach. 51% of the 130 articles included in the review focused on the topic of “Biochemical composition”, followed by “Water treatment” (18%) and “Ecophysiology” (15%). The most prominent application was “Pharmaceutics”, followed by “Cultivation” and “Fundamental research”. In order to provide a knowledge base to researchers and practitioners of C. lentillifera aquaculture, research that was simultaneously grouped under one of the topics “Biochemical composition”, “Water treatment”, or “Ecophysiology” and the applications “Cultivation”, “Nutritional value” or “Post-harvest” was summarized in more detail. Light management of sea grapes, their use as a high-value co-culture species and the capacity to bioremediate nutrients, as well as their short shelf-life were identified as important areas of research interest. The assessment revealed several knowledge gaps, for example the need for intra-species comparisons of C. lentillifera biochemical composition across spatial and temporal scales.
Gender Gaps in Commuting Time: Evidence from Peru, Ecuador, Chile, and Colombia
Authors: Campaña Juan Carlos , Gimenez-Nadal J. Ignacio 
Published: July 2023

AbstractWe analyze the relationship between gender and the time devoted to commuting by men and women in four Latin American countries. Using data from time surveys from Peru (2010), Ecuador (2012), Chile (2015) and Colombia (2012 and 2017), we observe in all four countries that women devote less time to this activity compared to men, in both urban and rural areas This gender difference varies depending on the presence of children, the working hours, the type of employment, and the urban or rural status of the respondent. Our results contribute to the literature on gender differences in commuting time for a set of countries that have not been thoroughly analyzed, pointing to the responsibility for the care of children as a factor limiting the daily mobility of women in these countries.
Hydrolysis and condensation behavior of tetraethoxysilane, hexaethoxydisiloxane, and octaethoxytrisiloxane
Authors: Sato Yohei , Sugimoto Asahi , Iwashina Tatsuya , Hayami Ryohei , Yamamoto Kazuki , Gunji Takahiro 
Published: July 2023

AbstractIn the initial stage of the hydrolysis–condensation of tetraethoxysilane (TEOS), hexaethoxydisiloxane (HEDS) and octaethoxytrisiloxane (OETS) are formed. However, little is known about the hydrolysis–condensation of HEDS and OETS. In this study, the hydrolysis–condensation of TEOS, HEDS, and OETS was investigated. HEDS and OETS were synthesized from diethoxy(diisocyanato)silane, a raw material with controllable functionality. The hydrolysis of TEOS, HEDS, and OETS was analyzed by mass spectroscopy, gel permeation chromatography, and nuclear magnetic resonance. The hydrolysis–condensation product of TEOS was a three-dimensional network-type polysiloxane. The hydrolysis–condensation product of HEDS consisted mainly of four-membered cyclic siloxane. The hydrolysis–condensation product of OETS consisted mainly of various membered cyclic siloxanes.
Graphical Abstract
Effect of a Smartphone Application on Physical Activity and Weight Loss After Bariatric Surgery—Results from a Randomized Controlled Trial
Authors: Bonn Stephanie E. , Hult Mari , Spetz Kristina , Eke Helén , Andersson Ellen , Wirén Mikael , Löf Marie , Trolle Lagerros Ylva 
Published: July 2023

AbstractPurposeWays to motivate and support patients in being physically active after bariatric surgery are needed. This trial was aimed at evaluating the effect of using a smartphone application targeting physical activity during 12 weeks on moderate-to-vigorous physical activity (MVPA, primary outcome) and secondary outcomes of inactivity, light physical activity (LPA), body mass index (BMI), and percent total weight loss (%TWL) after bariatric surgery.Materials and MethodsData from a randomized controlled trial comprising 146 patients (79.5% women) undergoing bariatric surgery was analyzed. Mean age and BMI pre-surgery were 40.9 years and 40.5 kg/m2, respectively. Participants were randomized 1:1 to an intervention or a control group. Physical activity and body weight were objectively measured at baseline pre-surgery and post-surgery follow-ups after 6 weeks (weight only), 18 weeks, 6 months, and 1 year. Linear mixed models were fitted to assess longitudinal differences in outcomes between the groups.ResultsA significant effect of the intervention (group-by-time interaction 16.2, 95% CI 3.5 to 28.9) was seen for MVPA at 18 weeks; the intervention group had increased their MVPA since baseline, while the control group had decreased their MVPA. The control group had lowered their BMI approximately 1 kg/m2more than the intervention group at follow-up after 18 weeks and 12 months, yet, mean BMI did not differ between the groups. No intervention effect was seen on inactivity, LPA, or %TWL.ConclusionOur results indicate that use of a smartphone application targeting physical activity may have the potential to promote short-term MVPA post bariatric surgery.Trial RegistrationClinicaltrials.gov: NCT03480464Graphical Abstract
Janus kinase inhibitors effectively improve pain across different disease activity states in rheumatoid arthritis
Authors: De Stefano Ludovico , Bozzalla Cassione Emanuele , Bottazzi Francesca , Marazzi Elena , Maggiore Francesco , Morandi Valentina , Montecucco Carlomaurizio , Bugatti Serena 
Published: July 2023

AbstractPain remains one of the most difficult-to-treat domains in patients with rheumatoid arthritis (RA). In clinical trials, the Janus kinase inhibitors (JAKis) have demonstrated good efficacy in pain relief. Aim of our study was to evaluate the real-life effectiveness of JAKis in improving pain in patients with RA in different states of baseline disease activity. A monocentric prospective cohort of 181 RA patients starting treatment with JAKis was studied. Pain was evaluated on a 0–100 mm visual analogue scale (VAS). Clinically meaningful improvements over 24 weeks were defined as follows: proportion of patients achieving ≥ 30%, ≥ 50%, and ≥ 70% pain relief, and remaining pain ≤ 20 or ≤ 10 mm. Results were analysed after stratification for baseline inflammatory activity; patients with swollen joints and C-reactive protein ≤ 1 at treatment start were considered pauci-inflammatory. Proportion of patients who achieved ≥ 30%, ≥ 50% and ≥ 70% pain improvement at 24 weeks was 61.4%, 49.3% and 32.9%. Furthermore, 40.6% and 28.5% of the patients achieved thresholds of remaining pain equivalent to mild pain or no/limited pain. Pain improvements were more evident in patients naive to previous biologics, although nearly 30% of multiple failures achieved VAS ≤ 20 mm. No significant differences were observed in relation to monotherapy. Pauci-inflammatory patients at treatment start achieved good outcomes, with 40.4% experiencing ≥ 70% pain improvement, and 35.7% VAS ≤ 10 mm. JAKis show efficacy in pain relief in real life. The improvement of painful symptoms also in those patients with limited objective inflammation may open new perspectives on the management of difficult-to-treat RA.
Completeness Problem via Fixed Point Theory
Authors: Anjum Rizwan , Abbas Mujahid , Işık Hüseyin 
Published: July 2023

AbstractThe purpose of this paper is to present the notion of MR-Kannan type contractions using the generalized averaged operator. Several examples are provided to illustrate the concept presented herein. We provide a characterisation of normed spaces using MR-Kannan type contractions with a fixed point. We investigate the Ulam–Hyers stability and well-posedness result for the mappings presented here.
Update on the management of elderly patients with colorectal cancer
Authors: Soler-González Gemma , Sastre-Valera Javier , Viana-Alonso Antonio , Aparicio-Urtasun Jorge , García-Escobar Ignacio , Gómez-España María Auxiliadora , Guillén-Ponce Carmen , Molina-Garrido María José , Gironés-Sarrió Regina 
Published: July 2023

AbstractColorectal cancer (CRC) is one of the most common tumours worldwide, and 70% of CRC patients are over 65 years of age. However, the scientific evidence available for these patients is poor, as they are underrepresented in clinical trials. Therefore, a group of experts from the Oncogeriatrics Section of the Spanish Society of Medical Oncology (SEOM), the Spanish Cooperative Group for the Treatment of Digestive Tumours, (TTD) and the Multidisciplinary Spanish Group of Digestive Cancer (GEMCAD) have reviewed the scientific evidence available in older patients with CRC. This group of experts recommends a multidisciplinary approach and geriatric assessment (GA) before making a therapeutic decision because GA predicts the risk of toxicity and survival and helps to individualize treatment. In addition, elderly patients with localized CRC should undergo standard cancer resection, preferably laparoscopically. The indication for adjuvant chemotherapy (CT) should be considered based on the potential benefit, the risk of recurrence, the life expectancy and patient comorbidities. When the disease is metastatic, the possibility of radical treatment with surgery, radiofrequency (RF) or stereotactic body radiation therapy (SBRT) should be considered. The efficacy of palliative CT is similar to that seen in younger patients, but elderly patients are at increased risk of toxicity. Clinical trials should be conducted with the elderly population and include GAs and specific treatment plans.
The cognitive basis for virtual reality rehabilitation of upper-extremity motor function after neurotraumas
Authors: Dewil Sophie , Kuptchik Shterna , Liu Mingxiao , Sanford Sean , Bradbury Troy , Davis Elena , Clemente Amanda , Nataraj Raviraj 
Published: July 2023

AbstractThis paper aims to present previous works in augmented sensory guidance for motor learning and psychophysiological factors and contextualize how these approaches may facilitate greater optimization of motor rehabilitation after neurotraumas with virtual reality. Through library resources at Stevens Institute of Technology, we searched for related works using multiple electronic databases and search engines with a medical focus (detailed in the paper). Searches were for articles published between 1980 and 2023 examining upper extremity rehabilitation, virtual reality, cognition, and modes and features of sensory feedback (specific search terms detailed in the paper). Strategic activation of sensory modalities for augmented guidance using virtual reality may improve motor training to develop further skill retention in persons suffering from impulsive neurological damage. Features with unique motor learning characteristics to consider with augmented feedback signals include representation, timing, complexity, and intermittency. Furthermore, monitoring psychophysiological factors (e.g., sense of agency, cognitive loading, attention) that represent mental and psychological processes may assist in critically evaluating novel designs in computerized rehabilitation. Virtual reality approaches should better incorporate augmented sensory feedback and leverage psychophysiological factors to advance motor rehabilitation after neurotraumas.
Respiratory Fungal Infections in Cystic Fibrosis: Diagnostic and Therapeutic Challenges
Authors: Schwarz C. , Mainz J. G. , Romanowska E. , Rosseau S. , Schuette H. , Martin-Souto L. , Ramirez-Garcia A. , Eschenhagen P. 
Published: July 2023

Abstract
Purpose of Review
In cystic fibrosis (CF), the main focus in bronchopulmonary infections is on bacterial pathogens, as they significantly influence lung function and the exacerbation rate. In the last decade, fungal respiratory diseases have been increasingly investigated for their impact on the clinical course of people with CF. This review aims to highlight recent findings in diagnostics and therapeutic approaches in terms of fungal infections in CF.

Recent Findings
We reviewed over 100 publications on fungal species in CF. Studies showed that Aspergillus spp. negatively impact lung function in patients with CF. A summary of these investigations showed that fungal diseases in patients with CF present as colonization, sensitization, bronchitis, pneumonia, allergic bronchopulmonary aspergillosis, and aspergilloma. Two significant fungal infections, pneumonia and bronchitis, are now well-defined, and several studies have established treatment options. The following pathogens are considered the primary cause of bronchitis, i.e., Aspergillus spp. and Exophiala spp., and of pneumonia, i.e., Scdedosporium spp., Apergillus spp., Trichosporon spp., and Candida spp. The main therapeutic innovations highlighted were real-time PCR techniques, DNA chips, and antigen-reactive T cell enrichment assay (ARTE).

Summary
Respiratory fungal infections in CF are a complex task in terms of definition and therapy.
Translational control of SOG1 expression in response to replication stress in Arabidopsis
Authors: Li Jinchao , Qian Weiqiang 
Published: July 2023

AbstractDNA damage, which may arise from cellular activities or be induced by genotoxic stresses, can cause genome instability and significantly affect plant growth and productivity. In response to genotoxic stresses, plants activate the cellular DNA damage response (DDR) to sense the stresses and activate downstream processes. The transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1), a functional counterpart of mammalian p53, is a master regulator of the DDR in plants. It is activated by various types of DNA lesions and can activate the transcription of hundreds of genes to trigger downstream processes, including cell cycle arrest, DNA repair, endoreplication, and apoptosis. Since SOG1 plays a crucial role in DDR, the activity of SOG1 must be tightly regulated. A recent study published in Plant Cell (Chen et al., Plant Cell koad126, 2023) reports a novel mechanism by which the ATR-WEE1 kinase module promotes SOG1 translation to fine-tune replication stress response.
Efficacy and utility of a tool for both measurement of vitamin B6, B12, D, folate and iron status and assessment of diet quality in athletes
Authors: Baart A. Mireille , Slotegraaf Anne I. , Gobes-de Punder Inge E. , Mensink Marco , Wardenaar Floris , de Vries Jeanne H.M. , Klein Gunnewiek Jacqueline M.T. , Balvers Michiel G.J. , Terink Rieneke 
Published: July 2023

Abstract
NutriProfiel® is a tool to measure micronutrient status and to assess diet quality. It consists of measurement of micronutrient status in blood and a short food frequency questionnaire (FFQ) (‘Eetscore-FFQ’). Based on the results, individuals receive a dietary advice. In this study, we evaluated the application of NutriProfiel in athletes (‘NutriProfiel-Sport’) by assessing the coverage of nutrient intake of the Eetscore-FFQ (part 1) and by evaluating athlete's dietary behaviour after using NutriProfiel-Sport and their satisfaction with this tool (part 2). For part 1, data of 419 athletes were used. We evaluated the coverage of nutrient intake of the Eetscore-FFQ using first and second MOMents (MOM1 and MOM2) sum scores of food items in the questionnaire. Forty-eight athletes were involved in part 2. They gave blood samples for micronutrient status measurement and were asked to complete the Eetscore-FFQ at baseline and after 3 months, as well as a questionnaire on their satisfaction with NutriProfiel-Sport. Results showed that for most nutrients, MOM1 and MOM2 scores were above 80 %, meaning that nutrient intake was sufficiently covered by the Eetscore-FFQ. No difference in diet quality was observed between baseline and after 3 months. Nevertheless, a majority of athletes reported the NutriProfiel-Sport results and advice as useful. On a scale from 0 to 10, NutriProfiel-Sport was graded with a mean (±sd) score of 7⋅6 (±0⋅8). In conclusion, NutriProfiel-Sport is a potential valuable and appreciated tool for athletes and the Eetscore-FFQ as part of this tool sufficiently covers nutrient intake in athletes.
Feasibility and implementation of a grocery shopping intervention for adults diagnosed with or at-risk for type 2 diabetes
Authors: Hollis-Hansen Kelseanna , Tan Sherey , Bargnesi Sarah , McGovern Lily , Drozdowsky Julia , Epstein Leonard H , Leone Lucia A , Mak Eunice , Masci Jaclyn , Anzman-Frasca Stephanie 
Published: July 2023

AbstractObjective:To examine the feasibility and implementation of an optimal defaults intervention designed to align grocery purchases with a diet recommended for people with or at-risk for type 2 diabetes.Design:This was a 5-week pilot randomised trial with three groups: in-person grocery shopping, shopping online and shopping online with ‘default’ carts. Participants were asked to shop normally in Week One, according to group assignment in Weeks Two–Four (intervention period), and as preferred in Week Five. All groups received diabetes-friendly recipes via email each intervention week.Setting:Participants grocery shopped in person or online. Grocery receipt forms, enrolment information and exit surveys were collected remotely and used to assess feasibility and implementation.Participants:Sixty-five adults with or at-risk for type 2 diabetes.Results:Sixty-two participants completed the exit survey and fifty-five submitted receipts all 5 weeks. Forty utilised recipes, 95 % of whom indicated recipes were somewhat or very useful. Orange chicken, quesadillas and pork with potato and apples were the most liked recipes. Most Defaults group participants accepted at least some default cart items. Recipes with the highest default acceptance were whole grain pasta and chicken, quesadillas with black beans and chicken with olives. Participants’ primary concerns about the intervention were costs associated with online shopping, inability to select preferred foods and some recipes including ingredients household members would not eat.Conclusions:The study had high retention, data were successfully collected remotely and the intervention was acceptable to most participants. Tailoring recipes to household preferences may be beneficial in future studies.
Relationships between the maternal prenatal diet and epigenetic state in infants: a systematic review of human studies
Authors: Fernando Kathya K. , Craig Jeffrey M. , Dawson Samantha L. 
Published: July 2023

AbstractMost human studies investigating the relationship between maternal diet in pregnancy and infant epigenetic state have focused on macro- and micro-nutrient intake, rather than the whole diet. This makes it difficult to translate the evidence into practical prenatal dietary recommendations.To review the evidence on how the prenatal diet relates to the epigenetic state of infants measured in the first year of life via candidate gene or genome-wide approaches.Following the PRISMA guidelines, this systematic literature search was completed in August 2020, and updated in August 2021 and April 2022. Studies investigating dietary supplementation were excluded. Risk of bias was assessed, and the certainty of results was analysed with consideration of study quality and validity.Seven studies were included, encompassing 6852 mother-infant dyads. One study was a randomised controlled trial and the remaining six were observational studies. There was heterogeneity in dietary exposure measures. Three studies used an epigenome-wide association study (EWAS) design and four focused on candidate genes from cord blood samples. All studies showed inconsistent associations between maternal dietary measures and DNA methylation in infants. Effect sizes of maternal diet on DNA methylation ranged from very low (< 1%) to high (> 10%). All studies had limitations and were assessed as having moderate to high risk of bias.The evidence presented here provides very low certainty that dietary patterns in pregnancy relate to epigenetic state in infants. We recommend that future studies maximise sample sizes and optimise and harmonise methods of dietary measurement and pipelines of epigenetic analysis.
Topological Characterization of a Fault Network Along the Northern North Sea Rift Margin
Authors: Osagiede Edoseghe E. , Nixon Casey W. , Gawthorpe Rob , Rotevatn Atle , Fossen Haakon , Jackson Christopher A.‐L. , Tillmans Fabian 
Published: July 2023

AbstractThe factors that control the spatial variation of the topological characteristics of normal fault networks at the rift‐scale are poorly understood. Here, we use 3D seismic reflection data from the northern North Sea to investigate the spatial variation of the geometry, topology, and strain heterogeneity of the Late Jurassic normal fault network along the rift margin. Our results show that fault orientation varies spatially along the rift margin. Normal faults within fault blocks that are adjacent to the North Viking Graben exhibits dominant N‐S and NE‐SW strikes that are sub‐parallel to the graben axis and associated step‐over, whereas in fault blocks farther from the graben, there is a dominant NW‐SE strike. Furthermore, we identify two broad topological domains within the fault network: (a) dominated by isolated nodes, partially connected branches, and low fault connectivity, and (b) dominated by abutting nodes, fully connected branches, and moderate to high fault connectivity. These topological domains correlate with previous sub‐division of the rift margin in the northern North Sea into platform and sub‐platform structural domains, respectively. There is also a positive correlation between the spatial variability of the fault orientations and intensity, with the fault network connectivity, highlighting the relationship between normal fault geometry and topology. We conclude that the across and along‐strike variation in strain, presence of pre‐existing structures, and accommodation zone‐related deformation are key factors influencing the spatial variation of fault network properties at the rift scale.