bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of boron oxide on the microstructure and hydration of calcium sulfoaluminate phase
Authors: Ma Qinchuan , Song Fei , Lyu Yinong , Li Geng , Peng Meixun , Zhao Hongwei 
Published: June 2023

AbstractBoron-rich waste causes numerous environmental problems when discharged directly into the environment. Here, various quantities of boron oxide (B2O3) were added to calcium sulfoaluminate (C4A3$) during the sintering process to demonstrate a potential use of boron-rich waste. The microstructure and hydration performance of C4A3$ with various B2O3contents were investigated with scanning electron microscopy, x-ray diffraction, isothermal conduction calorimetry, thermogravimetric studies and compressive strength tests. B2O3-doped C4A3$ had a larger grain size than the pure phase; and were surrounded by amorphous phases. The presence of B2O3was shown to promote the phase transition process through which C4A3$ changes from the orthorhombic to the cubic structure; and the substitution of Al3+for B3+in AlO4tetrahedra was surveyed by structural refinements. As the B2O3content increased, the induction period of C4A3$ increased while the hydration rate decreased because of the amorphous phases around the C4A3$. However, the hydration degree of doped C4A3$ increased due to the slower reaction rate. Thus, when an appropriate amount of B2O3was added to the C4A3$ during sintering, a significant improvement in the compressive strength of pastes was observed.
Applications and resource reductions in measurement-based variational quantum eigensolvers
Authors: Marqversen Frederik Kofoed , Zinner Nikolaj Thomas 
Published: June 2023

Abstract
We discuss the procedure for obtaining measurement-based implementations of quantum algorithms given by quantum circuit diagrams and how to reduce the required resources needed for a given measurement-based computation. This forms the foundation for quantum computing on photonic systems in the near term. To demonstrate that these ideas are well grounded we present three different problems which are solved by employing a measurement-based implementation of the variational quantum eigensolver algorithm (MBVQE). We show that by utilising native measurement-based gates rather than standard gates, such as the standard controlled not gate (CNOT), measurement-based quantum computations may be obtained that are both shallow and have simple connectivity while simultaneously exhibiting a large expressibility. We conclude that MBVQE has promising prospects for resource states that are not far from what is already available today.
Potential impact of stratospheric aerosol geoengineering on projected temperature and precipitation extremes in South Africa
Authors: Patel Trisha D , Odoulami Romaric C , Pinto Izidine , Egbebiyi Temitope S , Lennard Christopher , Abiodun Babatunde J , New Mark 
Published: June 2023

Abstract
Stratospheric aerosol injection (SAI) is the theoretical deployment of sulphate particles into the stratosphere to reflect incoming solar radiation and trigger a cooling impact at the Earth’s surface. This study assessed the potential impact of SAI geoengineering on temperature and precipitation extremes over South Africa (SAF) and its climatic zones in the future (2075–2095) using simulations from the Stratospheric Aerosol Geoengineering Large Ensemble (GLENS) project. We analyse three different experiments from the GLENS project, each of which simulate stratospheric SO2 injection under the representative concentration pathway 8.5 (RCP8.5) emissions scenario: (i) tropical injection around 22.8–25 km altitude (GLENS), (ii) tropical injection around 1 km above the tropopause (GLENS_low), and (iii) injection near the equator around 20–25 km (GLENS_eq). The study used a set of the Expert Team on Climate Change Detection and Indices describing temperature and rainfall extremes to assess the impact of the three SAI experiments on extreme weather in the future over SAF. The results of this study indicate that, relative to the baseline period (2010–2030), all three SAI experiments are mostly over-effective in offsetting the projected RCP8.5 increase in the frequency of hot (up to −60%) and decrease (up to +10%) in cold temperature extremes over SAF and its climatic zones. These findings suggest that SAI could cause over-cooling in SAF. However, SAI impact on precipitation extremes is less linear and varies across the country’s climatic zones. For example, SAI could reinforce the projected decrease in precipitation extremes across most of SAF, although it could exacerbate heavy precipitation over the KwaZulu-Natal Coast. These findings are consistent across SAI experiments except in magnitude, as GLENS_eq and GLENS_low could cause larger decreases in precipitation extremes than GLENS. These findings imply that SAI could alleviate heat stress on human health, agriculture, and vulnerable communities while simultaneously decreasing infrastructure and crops’ vulnerability to flooding. It is, however, essential to interpret these findings cautiously as they are specific to the SAI experiments and modelling settings considered in the GLENS project.
Sex Differences in Atrial Fibrillation and Associated Complications in Hypertensive Patients with Left Ventricular Hypertrophy: The LIFE Study
Authors: Feinberg Joshua B , Nielsen Emil E , Kjeldsen Sverre E , Devereux Richard B , Gerdts Eva , Wachtell Kristian , Olsen Michael H 
Published: June 2023

Abstract

BACKGROUND
There is no consensus on whether biological differences account for the higher risk of stroke seen in females compared to males with atrial fibrillation (AF).

METHODS
Capitalizing on The Losartan Intervention for Endpoint study, a multicenter randomized clinical trial randomizing 9,193 patients and followed for at least four years, we aimed to identify sex differences in the risk of stroke in the presence of AF in patients with hypertension and left ventricular hypertrophy (LVH).

RESULTS
342 Patients had a history of AF, and 669 developed new-onset AF. History of AF and new-onset AF were more prevalent among males (5.0% vs. 2.9% and 3.0% vs. 0.9%) in patients aged 55–63 years, but the relative difference decreased with age. Females with new-onset AF tended to have a higher risk of stroke than males (HR 1.52 [95% CI 0.95–2.43]). However, females with a history of AF did not have a higher risk than males (HR 0.88 [95% CI 0.5–1.6]). In patients with new-onset AF, the relative higher stroke risk in females increased with age. Among patients with a history of AF, stroke risk was comparable and increased with age in both sexes.

CONCLUSIONS
Among patients with hypertension and LVH, females with new-onset AF had a higher risk of stroke than males, especially in patients above 64 years. However, the risk did not differ between the sexes among patients with a history of AF.
Exposed anthocyanic leaves of Prunus cerasifera are special shade leaves with high resistance to blue light but low resistance to red light against photoinhibition of photosynthesis
Authors: Liu Lu , Fu Zengjuan , Wang Xiangping , Xu Chengyang , Gan Changqing , Fan Dayong , Soon Chow Wah 
Published: June 2023

Abstract

Background and Aims
The photoprotective role of foliar anthocyanins has long been ambiguous: exacerbating, being indifferent to or ameliorating the photoinhibition of photosynthesis. The photoinhibitory light spectrum and failure to separate photo-resistance from repair, as well as the different methods used to quantify the photo-susceptibility of the photosystems, could lead to such a discrepancy.

Methods
We selected two congeneric deciduous shrubs, Prunus cerasifera with anthocyanic leaves and Prunus triloba with green leaves, grown under identical growth conditions in an open field. The photo-susceptibilities of photosystem II (PSII) and photosystem I (PSI) to red light and blue light, in the presence of lincomycin (to block the repair), of exposed leaves were quantified by a non-intrusive P700+ signal from PSI. Leaf absorption, pigments, gas exchange and Chl a fluorescence were also measured.

Key Results
The content of anthocyanins in red leaves (P. cerasifera) was &gt;13 times greater than that in green leaves (P. triloba). With no difference in maximum quantum efficiency of PSII photochemistry (Fv/Fm) and apparent CO2 quantum yield (AQY) in red light, anthocyanic leaves (P. cerasifera) showed some shade-acclimated suites, including lower Chl a/b ratio, lower photosynthesis rate, lower stomatal conductance and lower PSII/PSI ratio (on an arbitrary scale), compared with green leaves (P. triloba). In the absence of repair of PSII, anthocyanic leaves (P. cerasifera) showed a rate coefficient of PSII photoinactivation (ki) that was 1.8 times higher than that of green leaves (P. triloba) under red light, but significantly lower (−18 %) under blue light. PSI of both types of leaves was not photoinactivated under blue or red light.

Conclusions
In the absence of repair, anthocyanic leaves exhibited an exacerbation of PSII photoinactivation under red light and a mitigation under blue light, which can partially reconcile the existing controversy in terms of the photoprotection by anthocyanins. Overall, the results demonstrate that appropriate methodology applied to test the photoprotection hypothesis of anthocyanins is critical.
Shareholder reflective loss: a bogeyman in investment treaty arbitration?
Authors: Ren Raphael 
Published: June 2023

Abstract
Most advanced national legal systems bar shareholders from claiming the diminution in value of their shareholding in a company arising from wrongful acts committed against the company. In contrast, investment arbitral tribunals consistently allow investors to recover such loss because most investment treaties are formulated broadly to protect investments in the form of direct and indirect shareholding. Despite recent calls for reform by governments and inter-governmental organizations, there is nothing inherently wrong with such dissonance. First, the recoverability of ‘shareholder reflective loss’ is doctrinally in sync with the lex specialis characteristics of investment treaty claims. Second, as recently and rightly recognized by the apex courts of the UK and Singapore, the principle of ‘no reflective loss’ is founded upon separation of legal personality rather than prevention of double recovery. In investment treaty arbitration, the latter concern is sufficiently addressed by solutions ranging from jurisdictional barriers (fork-in-the-road and denial of benefits clauses), procedural devices (consolidation and joinder), and substantive defences (res judicata, collateral estoppel, and abuse of process). Hence, the growing fear of shareholder reflective loss undermining the investor–State dispute settlement system is but a bogeyman that States need not be afraid of.
LEGO-CSM: a tool for functional characterization of proteins
Authors: Nguyen Thanh Binh , de Sá Alex G C , Rodrigues Carlos H M , Pires Douglas E V , Ascher David B 
Published: June 2023

Abstract

Motivation
With the development of sequencing techniques, the discovery of new proteins significantly exceeds the human capacity and resources for experimentally characterizing protein functions. Localization, EC numbers, and GO terms with the structure-based Cutoff Scanning Matrix (LEGO-CSM) is a comprehensive web-based resource that fills this gap by leveraging the well-established and robust graph-based signatures to supervised learning models using both protein sequence and structure information to accurately model protein function in terms of Subcellular Localization, Enzyme Commission (EC) numbers, and Gene Ontology (GO) terms.

Results
We show our models perform as well as or better than alternative approaches, achieving area under the receiver operating characteristic curve of up to 0.93 for subcellular localization, up to 0.93 for EC, and up to 0.81 for GO terms on independent blind tests.

Availability and implementation
LEGO-CSM’s web server is freely available at https://biosig.lab.uq.edu.au/lego_csm. In addition, all datasets used to train and test LEGO-CSM’s models can be downloaded at https://biosig.lab.uq.edu.au/lego_csm/data.
Robust joint clustering of multi-omics single-cell data via multi-modal high-order neighborhood Laplacian matrix optimization
Authors: Jiang Hao , Zhan Senwen , Ching Wai-Ki , Chen Luonan 
Published: June 2023

Abstract

Motivation
Simultaneous profiling of multi-omics single-cell data represents exciting technological advancements for understanding cellular states and heterogeneity. Cellular indexing of transcriptomes and epitopes by sequencing allowed for parallel quantification of cell-surface protein expression and transcriptome profiling in the same cells; methylome and transcriptome sequencing from single cells allows for analysis of transcriptomic and epigenomic profiling in the same individual cells. However, effective integration method for mining the heterogeneity of cells over the noisy, sparse, and complex multi-modal data is in growing need.

Results
In this article, we propose a multi-modal high-order neighborhood Laplacian matrix optimization framework for integrating the multi-omics single-cell data: scHoML. Hierarchical clustering method was presented for analyzing the optimal embedding representation and identifying cell clusters in a robust manner. This novel method by integrating high-order and multi-modal Laplacian matrices would robustly represent the complex data structures and allow for systematic analysis at the multi-omics single-cell level, thus promoting further biological discoveries.

Availability and implementation
Matlab code is available at https://github.com/jianghruc/scHoML.
Information-incorporated sparse convex clustering for disease subtyping
Authors: Zhang Xiaoyu , Liu Ching-Ti 
Published: June 2023

Abstract

Motivation
Heterogeneity in human diseases presents clinical challenges in accurate disease characterization and treatment. Recently available high throughput multi-omics data may offer a great opportunity to explore the underlying mechanisms of diseases and improve disease heterogeneity assessment throughout the treatment course. In addition, increasingly accumulated data from existing literature may be informative about disease subtyping. However, the existing clustering procedures, such as Sparse Convex Clustering (SCC), cannot directly utilize the prior information even though SCC produces stable clusters.

Results
We develop a clustering procedure, information-incorporated Sparse Convex Clustering, to respond to the need for disease subtyping in precision medicine. Utilizing the text mining approach, the proposed method leverages the existing information from previously published studies through a group lasso penalty to improve disease subtyping and biomarker identification. The proposed method allows taking heterogeneous information, such as multi-omics data. We conduct simulation studies under several scenarios with various accuracy of the prior information to evaluate the performance of our method. The proposed method outperforms other clustering methods, such as SCC, K-means, Sparse K-means, iCluster+, and Bayesian Consensus Clustering. In addition, the proposed method generates more accurate disease subtypes and identifies important biomarkers for future studies in real data analysis of breast and lung cancer-related omics data. In conclusion, we present an information-incorporated clustering procedure that allows coherent pattern discovery and feature selection.

Availability and implementation
The code is available upon request.
Cytomolecular characterization of early and late condensing chromosome regions in some Annonaceae species
Authors: Santos Amanda , Nascimento Thiago , ﻿Felix Leonardo P , Guerra Marcelo 
Published: June 2023

Abstract
The condensation patterns (CPs) of prophase chromosomes represent poorly explored and little understood karyotype features. Three distinct chromosome domains are observed in conventionally stained prophases of most angiosperms with small chromosomes: heterochromatin and early condensing euchromatin (ECEu), which are observed as early condensing regions (ECRs), and late condensing euchromatin or late condensing regions (LCRs). All three prophase domains have been often reported in the Annonaceae species. To gain a better understanding of these regions, we investigated the CPs, heterochromatic bands, and rDNA sites in seven Annona species with 2n = 14, 28, and 54 and Xylopiafrutescens with 2n = 16. Besides, histone H4K5 acetylation, telomeric sites, and DNA methylation were analysed in some of these species. LCRs corresponded to a small hyperacetylated, and hypomethylated fraction of the metaphase chromosomes. During interphase, the chromocentres displayed variable proportions of heterochromatin and ECEu. The LCRs and ECRs were conserved even between disploid and polyploid species, whereas rDNA sites and heterochromatic bands varied in number and location. Our data suggest that chromatin compartmentalization in ECR and LCR regions may represent the simplest functional organization of the small chromosomes of Annonaceae, while the remaining characters are less relevant.
Notch4 participates in mesenchymal stem cell-induced differentiation in 3D-printed matrix and is implicated in eccrine sweat gland morphogenesis
Authors: Wang Yuzhen , Zhang Fanliang , Yao Bin , Hou Linhao , Li Zhao , Song Wei , Kong Yi , Tan Yaxin , Fu Xiaobing , Huang Sha 
Published: June 2023

Abstract

Background
Eccrine sweat gland (SG) plays a crucial role in thermoregulation but exhibits very limited regenerative potential. Although SG lineage-restricted niches dominate SG morphogenesis and benefit SG regeneration, rebuilding niches in vivo is challenging for stem cell therapeutic applications. Hence, we attempted to screen and tune the critical niche-responding genes that dually respond to both biochemical and structural cues, which might be a promising strategy for SG regeneration.

Methods
An artificial SG lineage-restricted niche consisting of mouse plantar dermis homogenates (i.e. biochemical cues) and 3D architecture (i.e. structural cues) was built in vitro by using an extrusion-based 3D bioprinting approach. Mouse bone marrow-derived mesenchymal stem cells (MSCs) were then differentiated into the induced SG cells in the artificial SG lineage-restricted niche. To decouple biochemical cues from structural cues, the transcriptional changes aroused by pure biochemical cues, pure structural cues and synergistic effects of both cues were analyzed pairwise, respectively. Notably, only niche-dual-responding genes that are differentially expressed in response to both biochemical and structural cues and participate in switching MSC fates towards SG lineage were screened out. Validations in vitro and in vivo were respectively conducted by inhibiting or activating the candidate niche-dual-responding gene(s) to explore the consequent effects on SG differentiation.

Results
Notch4 is one of the niche-dual-responding genes that enhanced MSC stemness and promoted SG differentiation in 3D-printed matrix in vitro. Furthermore, inhibiting Notch4 specifically reduced keratin 19-positive epidermal stem cells and keratin 14-positive SG progenitor cells, thus further delaying embryonic SG morphogenesis in vivo.

Conclusions
Notch4 not only participates in mouse MSC-induced SG differentiation in vitro but is also implicated in mouse eccrine SG morphogenesis in vivo.
A Multicenter Retrospective Cohort Study to Characterize Patients Hospitalized With Multisystem Inflammatory Syndrome in Adults and Coronavirus Disease 2019 in the United States, 2020–2021
Authors: Melgar Michael , Abrams Joseph Y , Godfred-Cato Shana , Shah Ami B , Garg Amit , Strunk Andrew , Narasimhan Mangala , Koptyev Jonathan , Norden Alexandra , Musheyev David , Rashid Fahmida , Tannenbaum Rachel , Estrada-Y-Martin Rosa M , Patel Bela , Karanth Siddharth , Achenbach Chad J , Hall Gavin T , Hockney Sara M , Caputo Matthew , Abbo Lilian M , Beauchamps Laura , Morris Stephen , Cifuentes Renzo O , de St Maurice Annabelle , Bell Douglas S , Prabaker Kavitha K , Sanz Vidorreta Fernando J , Bryant Evan , Cohen David K , Mohan Rohith , Libby Christopher P , SooHoo Spencer , Domingo Tristel J , Campbell Angela P , Belay Ermias D 
Published: June 2023

Abstract

Background
The diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–associated multisystem inflammatory syndrome in adults (MIS-A) requires distinguishing it from acute coronavirus disease 2019 (COVID-19) and may affect clinical management.

Methods
In this retrospective cohort study, we applied the US Centers for Disease Control and Prevention case definition to identify adults hospitalized with MIS-A at 6 academic medical centers from 1 March 2020 to 31 December 2021. Patients MIS-A were matched by age group, sex, site, and admission date at a 1:2 ratio to patients hospitalized with acute symptomatic COVID-19. Conditional logistic regression was used to compare demographic characteristics, presenting symptoms, laboratory and imaging results, treatments administered, and outcomes between cohorts.

Results
Through medical record review of 10 223 patients hospitalized with SARS-CoV-2–associated illness, we identified 53 MIS-A cases. Compared with 106 matched patients with COVID-19, those with MIS-A were more likely to be non-Hispanic black and less likely to be non-Hispanic white. They more likely had laboratory-confirmed COVID-19 ≥14 days before hospitalization, more likely had positive in-hospital SARS-CoV-2 serologic testing, and more often presented with gastrointestinal symptoms and chest pain. They were less likely to have underlying medical conditions and to present with cough and dyspnea. On admission, patients with MIS-A had higher neutrophil-to-lymphocyte ratio and higher levels of C-reactive protein, ferritin, procalcitonin, and D-dimer than patients with COVID-19. They also had longer hospitalization and more likely required intensive care admission, invasive mechanical ventilation, and vasopressors. The mortality rate was 6% in both cohorts.

Conclusions
Compared with patients with acute symptomatic COVID-19, adults with MIS-A more often manifest certain symptoms and laboratory findings early during hospitalization. These features may facilitate diagnosis and management.