bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macrophage phenotype impacts in vitro equine intrasynovial deep digital flexor tenocyte matrix metalloproteinase gene expression and secretion
Authors: Cooper Hannah E. , Bowlby Charles , Long Sidney , Durgam Sushmitha S. 
Published: September 2023

Abstract

OBJECTIVE
To investigate matrix metalloproteinase (MMP) and their inhibitors tissue inhibitor matrix metalloproteinase (TIMP) gene expression and secretion during equine deep digital flexor tendon (DDFT) tenocyte and macrophage (undifferentiated, proinflammatory, and regulatory) co-culture.

SAMPLE
Third passage DDF tenocytes and donor-matched macrophages differentiated from peripheral blood CD14+ monocytes from 5 healthy horses ages 9–11 years, euthanized for reasons unrelated to musculoskeletal conditions.

METHODS
Passage 3 DDT tenocyte aggregate cultures were co-cultured with undifferentiated (control), proinflammatory (granulocyte-macrophage colony-stimulating factor; GM-CSF pretreated and lipopolysaccharide + interferon gamma-primed; LPS+IFN-γ) or regulatory (interleukin-4 and interleukin-10-primed; IL-4 + IL-10) macrophages in direct and transwell co-cultures for 72 hours. MMP-1, -2, -3, -9, -13, and TIMP -1, -2 mRNA were measured via real-time Polymerase Chain Reaction (rtPCR). Co-culture media MMP -3, -9, and TIMP -1, -2 concentrations were quantified via ELISA.

RESULTS
Direct co-culture of DDF tenocytes with proinflammatory macrophages for 72 hours increased MMP-1, -3, and -13 mRNA levels whereas, MMP-9 mRNA levels decreased. Direct and transwell co-culture with proinflammatory and regulatory macrophages resulted in increased MMP-3 and decreased MMP-9 media concentrations. While direct co-culture with regulatory macrophages significantly increased TIMP-1 mRNA, overall, TIMP mRNA and culture media concentrations were largely unchanged.

CLINICAL RELEVANCE
Cell-to-cell contact between DDF tenocytes and macrophages is not essential to induce MMP gene expression and secretion. Co-culture systems offer a viable in vitro platform to screen and evaluate immunomodulatory properties of therapies aimed at improving equine intrasynovial tendon healing.
Physiologia e ética:
Authors: Rocha Everton da Silva 
Published: September 2023

Abordaremos nesse artigo o problema da coerência no pensamento de Epicuro e de sua unidade sistemática. A partir de críticas feitas contra o epicurismo ao longo da tradição pretendemos voltar aos textos fundamentais atribuídos a Epicuro e apresentar argumentos que demonstrem em Diôgenes Laêrtios, nas cartas e máximas uma unidade sistemática, que perpassa todo o conjunto da obra epicúrea. Defenderemos o posicionamento que physiologia e ética seriam separadas apenas para efeitos didáticos e teóricos. Na realidade elas fazem parte de um mesmo sistema filosófico. A continuidade entre physiologia e ética seria demonstrada nas posições epicúreas relacionadas aos problemas dos fenômenos celestes, dos limites para as dores e os prazeres, e principalmente da morte.
The Relation of Depression, Stress, Anxiety, and Burnout among Healthcare Workers during the Second Wave of COVID-19 Pandemic in India
Authors: Das Nikhita , Goswami Seujee , Mondal Aritra 
Published: September 2023

Objectives
The COVID-19 outbreak has taken a significant toll on frontline workers globally, resulting in psychological stress, burnout, and mental exhaustion. This online-based cross-sectional study aimed to explore the relationship between depression, anxiety, stress, and burnout among healthcare workers (HCWs) providing direct care to COVID-19 patients in the second wave of the COVID-19 pandemic in India.

Material and Methods
The sample size comprised HCWs who met specific inclusion criteria and had completed at least 1 week of posting in COVID-19 units and provided informed consent to participate. Data were collected using semi-structured socio-demographic Proforma, the Depression Anxiety Stress Scale-21 items (DASS-21), and the Copenhagen Burnout Inventory (CBI)-19 items.

Results
Out of 137 participants, 68.6% had moderate and 15.3% had severe depression; 48.9% had moderate and 24.1% had severe anxiety; and 3.6% had extremely severe anxiety. The prevalence of severe and extremely severe stress was 46.7 and 6.6%, respectively. The subscales of the Copenhagen Burnout Inventory, personal and work-related burnout had a positive correlation with all the subscales of the Depression Anxiety Stress Scale-21 items, while client-related burnout only correlated with the stress subscale.

Conclusion
The high prevalence of burnout and other mental health problems in the healthcare workers during the pandemic necessitate the need for the healthcare system to provide psychological support and interventions for physicians working during the pandemic.
Distal Tibial Fractures – Surgical Outcome Following Minimally Invasive Percutaneous Plate Osteosynthesis
Authors: Sajeed Mohamed , Nisha Nasrin , D Sivaraman , T Prabhu 
Published: September 2023

Objectives
With preservation of the vascularity of the bone, preservation of the soft tissue envelope and containment of the fracture haematoma, minimally invasive procedures provide fixation in a biologically sound manner. With these in view, this study was conducted to evaluate the technique of surgical management in distal tibial fractures treated by internal fixation with locking compression plate (LCP) and screws through the minimally invasive percutaneous plate osteosynthesis (MIPPO) technique.

Material and Methods
In this cohort study, 21 patients with distal tibial fractures who were admitted to the hospital between November 2014 and August 2016 were tracked for at least 10 weeks and up to 39 weeks. Adults who were fit enough for surgery, both male and female, participated in the study. MIPPO procedures were followed for every case. In this investigation, a total of 21 cases were examined.

Results
86% of cases with proper bone union were able to bear their full weight at or before the 18-week mark. Complete weight bearing was permitted for the final three patients (14%) at or before 39 weeks. Ninety per cent of patients had fracture union rates that were satisfactory to excellent at 23 weeks. Also, delayed unions were noted in three individuals; two cases experienced ankle stiffness, one as a result of prolonged immobilization and the other as a result of an intra-articular fracture. There were no infections or wound breakdowns during this trial.

Conclusion
The MIPPO technique with LCP plates is a good choice when intramedullary nailing is inadequate for metaphyseal and distal tibia shaft fractures. Also, early fracture union is easily accomplished using the MIPPO technique and careful application of these plates.
Xanthogranuloma of the suprasellar region mimicking cystic craniopharyngioma: A case report
Authors: Alghamdi Abdulaziz M. , Alghamdi Abdulkarim M. , Samkari Alaa , Samman Afnan , Lary Ahmed 
Published: September 2023

Background:
Xanthogranuloma of the sellar region is an extremely rare benign entity with only case reports and series documented in the literature. We aim to describe in this report a case of a suprasellar xanthogranuloma that was diagnosed initially as a cystic craniopharyngioma.

Case Description:
A 28-year-old woman presented to the clinic with a 2-week history of headaches, blurred vision, nausea, and vomiting. She had no medical or surgical history, no signs of hormonal disturbances, and no family history of brain tumors or endocrine diseases. Her neurological examination was unremarkable except for bitemporal hemianopia on visual field testing. A magnetic resonance imaging of the brain showed a cystic mass in the sellar region that was compressing the optic chiasm with radiological features representing cystic craniopharyngioma. She underwent endoscopic transnasal transsphenoidal surgery to excise the mass, and only subtotal excision was achieved to preserve the pituitary function. The histopathology confirmed the diagnosis of a xanthogranuloma of the sellar region. The postoperative course was unremarkable, and she did not receive any adjuvant therapy. There was no recurrence of the clinical symptoms or the mass during the 18-month follow-up period.

Conclusion:
Although xanthogranuloma is uncommon, it should be included in the differential diagnosis of sellar/suprasellar lesions. Due to its wide range of radiological features that sometimes can mimic other lesions, a definitive diagnosis can only be made postoperatively. Surgical excision is the most accepted treatment with a favorable prognosis and low rates of recurrence.
MODELS OF STOCK MARKET OPTIMIZATION IN ENGINEERING IN THE SOCIO-ECONOMIC ASPECT
Authors: Кузнецов В.П. , Лаврентьева Е.В. 
Published: September 2023

Цель статьи – рассмотреть и проанализировать состояние фондового рынка машиностроения в аспекте воздействий на него рыночного и инвестиционного рисков. Проведенный анализ участников рынка российских акций позволил осуществить сравнение действий основных игроков рынка: инвесторов и спекулянтов. Выявленные и обозначенные в статье действия на примере фондового рынка предприятий автопрома предоставили возможность выделить их цикличность и обозначить основные задачи инвесторов. В исследовании приведен комплекс математических методов и моделей управления финансовыми рисками: метод VAR, модель регрессионного анализа и оптимизационная модель тарификации в страховании. Научная новизна представлена разработанным инновационным базисом и рекомендациями по его использованию для фондового рынка предприятий машиностроения.
The article discusses the management of investment risks Industrial enterprises and investors in the Russian stock market. The analysis of the participants of the Russian stock market was carried out; the comparison of investors and speculators was carried out. The article discusses the trends in the market. An example of a trend is given and an analysis of cycles is carried out. The main tasks of speculators and the main tasks of investors are highlighted. The definition of technical and fundamental analysis is given, the classification of technical analysis is considered. The article calculates the method of investment risk management VAR. Recommendations have been developed to reduce investment risk for investors and speculators.
THE ACADEMIC PROGRAMM ON NATIONAL ECONOMY (PROJECT)
Authors: Альпидовская М.Л. , Шманев С.В. , Щербаков В.Н. , Донцова О.И. , Соколов Д.П. 
Published: September 2023

Вниманию читателя представлен проект рабочей программы дисциплины «Национальная экономика», разработанной преподавателями Департамента экономической теории Финансового университета. Её целью является: формирование целостного представления о функционировании национального хозяйства, его структуры, основных экономических субъектах и экономических отношениях, возникающих между ними в рамках воспроизводственного процесса; освоение комплекса знаний о многогранном опыте хозяйственной деятельности в России на разных этапах социально-экономического развития; изучение исторического опыта важнейших экономических реформ, обусловленных национальными особенностями.
The research presents a draft work program on “National Economy”, developed by teachers of the Department of Economic Theory of the Financial University, the purpose of which is to form a holistic view of the functioning of the national economy, its structure, the main economic entities, and economic relations arising between them in the framework of the reproductive process, the development of a complex of knowledge about the multifaceted experience of economic activity in Russia at different stages of socio-economic development, the study of the historical experience of the most important economic reforms caused by national characteristics.
Osseointegration effects of whey protein (histological and histomorphological observations): An experimental study on rabbits
Authors: Kamil Nawar B , AL-Ghaban Nada M H , Aamery Amaar 
Published: September 2023

Background: Whey protein is the green-yellow colored, liquid portion of the milk, and it is also called the cheese serum, it is obtained after the separation of curd, during the coagulation of the milk. It contains a considerable amount of α-helix pattern with an evenly distributed hydrophobic and hydrophilic as well as basic and acidic amino acids along with their polypeptide chain. The major whey protein constituents include β-lactoglobulin (β-LG),α-lactalbumin (α-LA), immunoglobulins (IG), bovine serum albumin (BSA), bovine lactoperoxidase (LP), bovine lactoferrin (BLF) and minor amounts of a glycol macro peptide (GMP). Osseointegration can be defined as a process that is immune driven which leads to the formation of the new bone surrounding the surface of the implant rather than a pure response of the bone. Titanium can activate a balance recognized to be tolerogenic with a peri-implant tissue leading to a "foreign body equilibrium (FBE)" response. Materials and methods: Twelve adult male white New Zealand healthy rabbits were used in this study, the animals were divided into two groups according to the time of scarification as follows; 2 and 6 weeks after the implantation (6 rabbits will be sacrificed for each group). Results: Statistical analysis showed that there is a highly significant difference in all parameters between the experimental group and control group at 2 weeks and 6 weeks periods. Histological results at 2 weeks period showed thread formation in whey protein and control group, distribution of osteocyte cells and osteoblast was higher in whey protein, and the bone trabecular area was also larger in whey protein groups but at 6 weeks showed mature bone in whey protein groups while in control group still woven bone. Conclusions: Whey protein is an effective in osseointegration because it enhances bone formation.
Immunostimulatory activity of avocado oil in mice (Mus musculus)
Authors: Jusuf Elena Adjani , Mustika Aulia Andi , Andriyanto Andriyanto 
Published: September 2023

Avocado fruit contains bioactive compounds that have the potential to act as an immunomodulator. This study aims to identify the ability of avocado oil as an immunomodulator based on the macrophage phagocytic activity and index of mice injected with nonpathogenic Staphylococcus aureus and to determine the most effective dose as an immunomodulator. This study used 30 male Deutschland Denken Yoken (DDY) mice, which were divided into five groups: placebo as negative control (mineral water), positive control (commercial immunomodulator containing Echinacea purpurea extract), and avocado oil 1 g/kg BW, 3 g/kg BW, and 5 g/kg BW. The treatment was carried out orally once a day for 14 days. Mice were induced by nonpathogenic Staphylococcus aureus on day 15 intraperitoneally, and after one hour, mice were euthanized to collect the peritoneal fluid. Peritoneal fluid smear preparations were made before active macrophages and phagocytosed Staphylococcus aureus were observed under a microscope. Phagocytic activity and phagocytic index were calculated. Avocado oil 5 g/kg BW showed the highest phagocytic activity and phagocytic index results with values of 71.00% ± 5.40% and 2.79 ± 0.14, respectively. Avocado oil enhances non-specific immune responses through macrophagephagocytic activity and index, demonstrating its immunostimulatory potential.
Multi-sensori dalam konsepsi tempat pada lingkungan cagar budaya perkotaan
Authors: Septianto Eggi , Djimantoro Michael Isnaeni , Noviandri Patricia Pahlevi , Firmansyah  , Poerbo Heru Wibowo , Martokusumo Widjaja 
Published: September 2023

Multi-sensori berpengaruh dalam mengenali sebuah tempat lebih baik. Proses mengenali tersebut perlu didukung oleh konsepsi tempat yang tidak dibatasi oleh aspek fisik saja. Pemahaman ini berlawanan dengan paradigma yang umum terjadi dalam pemahaman dan model pelestarian kawasan cagar budaya yang masih terbatas pada peningkatan kualitas fisik berdasarkan indra visual. Artikel ini mendiskusikan peran dan potensi multi-sensori dalam memahami konsepsi tempat yang bermanfaat pada pelestarian kawasan cagar budaya perkotaan. Penelitian ini menggunakan pengumpulan data dari studi kepustakaan dan pengamatan lapangan kawasan cagar budaya sekitar Gedung Sate kota Bandung. Hasil penelitian menunjukkan bahwa persepsi multi-sensori berperan serta berpotensi untuk mempermudah proses pembacaan dan merasakan tempat oleh individu. Diskusi ini membuka wacana baru untuk mengintegrasikan aspek non fisik berbasis persepsi subjek dalam diskusi kawasan cagar budaya perkotaan.
Implementasi Pembelajaran Berbasis Proyek untuk Meningkatkan Kemandirian Anak Usia Dini
Authors: Suci Ratu Ayuning , Fathiyah Kartika Nur 
Published: September 2023

Berbagai sikap yang harus dimiliki anak yaitu salah satunya kemandirian. Anak usia dini memerlukan sikap mandiri sebagai dasar bagi anak untuk dapat mengendalikan dirinya. Kemandirian pada anak usia dini dapat distimulus dengan berbagai metode pembelajaran. Metode pembelajaran berbasis proyek mampu menyampaikan pengetahuan yang menggembirakan bagi anak, metode proyek menciptakan anak untuk menjadi pribadi yang ingin tahu dan dapat bekerja sendiri maupun berkelompok. Penelitian ini dilakukan untuk mendeskripsikan implementasi dari pembelajaran berbasis metode proyek untuk meningkatkan kemandirian pada anak usia dini. Memakai pendekatan kualitatif deskriptif sebagai metode penelitian. Observasi, wawancara, dan dokumentasi sebagai teknik pengumpulan data dengan melibatkan guru orang dan kepala sekolah TK Great Rastera School Kecamatan Sunggal Kabupaten Deli Serdang. Data dianalisis secara deskriptif kualitatif dengan data direduksi, disajikan, dan diambil kesimpulan. Hasil dari penelitian menjunjukkan bahwa penggunaan metode berbasis proyek dapat meningkatkan kemandirian anak usia dini secara signifikan, dan memberikan manfaat untuk anak agar dapat bekerja secara mandiri maupun berkelompok.
Analisis Kemampuan Membaca Permulaan di Taman Kanak-Kanak
Authors: Kartika Wilda Isna , Putri Ayu Aprilia Pangestu 
Published: September 2023

Permasalahan mengenai kemampuan membaca anak Indonesia tampaknya masih harus menjadi perhatian. Urgensi kemampuan membaca seharusnya sudah dikenalkan sejak usia dini yang merupakan masa keemasaan seseorang. Penelitian ini bertujuan untuk menganalisis kegiatan kemampuan membaca permulaan anak di Taman kanak-kanak (TK) melalui metode dan bahan bacaan yang digunakan. Pendekatan penelitian menggunakan kualitatif jenis studi kasus. Data hasil yang diperoleh dari instrumen berupa pedoman wawancara dan instrumen kemampuan membaca permulaan dan dokumentasi dianalisis secara deskriptif model Miles Huberman. Hasil penelitian menunjukan bahwa anak memiliki kemampuan membaca permulaan yang baik berdasarkan indikator anak mampu membaca abjad, kata, kalimat, paragraf dan membaca buku dalam bahasa Inggris yang digunakan dalam pembelajaran. Berbagai penemuan baru seperti metode, bahan bacaan menjadi informasi yang dapat TK terapkan untuk menstimulasi kemampuan membaca permulaan. Penelitian selanjutnya diharapkan dapat menguji hasil temuan diberbagai TK di Indonesia sehingga mendapatkan informasi mengenai efektivitas hasil temuan tersebut.
Impact of Adjuvant Gemcitabine Containing Chemotherapy Following Radical Nephroureterectomy for Patients with Upper Tract Urothelial Carcinoma: Results from a Propensity-Score Matched Cohort Study
Authors: Hongda Zhao , Kang Liu , Ng Chi-Fai , de la Rosette Jean , Laguna Pilar , Gontero Paolo , Baard Joyce , Yildiz Ozcan , Teoh Jeremy Yuen-Chun 
Published: September 2023

BACKGROUND: The evidence regarding perioperative adjuvant chemotherapy and personalized surveillance strategies for upper tract urothelial carcinoma is limited. OBJECTIVE: To evaluate whether adjuvant gemcitabine containing chemotherapy affects the oncological outcomes of advanced upper tract urothelial carcinoma (UTUC). METHODS: The CROES-UTUC registry is an observational, international, multi-center study on patients diagnosed with UTUC. Patient and disease characteristics from 2380 patients with UTUC were collected, and finally 738 patients were included in this analysis. The primary outcome of this study was recurrence-free survival. Propensity score matching was performed. Kaplan-Meier and multivariate Cox regression analyses were performed by stratifying patients according to the treatment of adjuvant chemotherapy. RESULTS: A total of 738 patients were included in this analysis, and 59 patients received adjuvant chemotherapy (AC), including 50 patients who received gemcitabine. A propensity score matching was performed, including 50 patients who received gemcitabine containing treatment and 50 patients without adjuvant chemotherapy. Disease recurrence occurred in 34.0% of patients. The recurrence rate in the AC group was 22.0%, which was significantly lower than the non-AC group (46.0%). Kaplan-Meier analyses also showed that AC was associated with a lower likelihood of tumor recurrence ( p = 0.047). However, AC was not significantly associated with a higher overall survival (OS) ( p = 0.908) and cancer-specific survival (CSS) ( p = 0.979). Upon multivariate Cox regression analysis, AC was associated with a lower risk of tumor recurrence (HR = 0.297, p = 0.028). CONCLUSION: The present study confirms that adjuvant gemcitabine containing chemotherapy could decrease the risk of tumor recurrence in patients with locally advanced UTUC following nephroureterectomy. However, more studies are need to draw a clearer image of the value of this treatment method.
Interventions to help patients withdraw from depression drugs: A systematic review
Authors: Gøtzsche Peter C. , Demasi Maryanne 
Published: September 2023

BACKGROUND: Depression drugs can be difficult to come off due to withdrawal symptoms. Gradual tapering with tapering support is needed to help patients withdraw safely. OBJECTIVE: To review the withdrawal success rates, using any intervention, and the effects on relapse/recurrence rates, symptom severity, quality of life, and withdrawal symptoms. METHODS: Systematic review based on PubMed and Embase searches (last search 4 October 2022) of randomised trials with one or more treatment arms aimed at helping patients withdraw from a depression drug, regardless of indication for treatment. We calculated the mean and median success rates and the risk difference of depressive relapse when discontinuing or continuing depression drugs. RESULTS: We included 13 studies (2085 participants). Three compared two withdrawal interventions and ten compared drug discontinuation vs. continuation. The success rates varied hugely between the trials (9% to 80%), with a weighted mean of 47% (95% confidence interval 38% to 57%) and a median of 50% (interquartile range 29% to 65%). A meta-regression showed that the length of taper was highly predictive for the risk of relapse (P = 0.00001). All the studies we reviewed confounded withdrawal symptoms with relapse; did not use hyperbolic tapering; withdrew the depression drug too fast; and stopped it entirely when receptor occupancy was still high. CONCLUSION: The true proportion of patients on depression drugs who can stop safely without relapse is likely considerably higher than the 50% we found.
Reflexão sobre os benefícios do mapeamento do processo de auditoria de qualidade em uma Seguradora de Saúde
Authors: Lima Antonio Fernandes Costa , Prates Vigna Cinthia 
Published: September 2023

Objetivo: promover a reflexão em relação aos benefícios do mapeamento do processo de auditoria de qualidade em uma Seguradora de Saúde de grande porte. Métodos: Estudo de caso exploratório, descritivo-reflexivo, retrospectivo, conduzido no Departamento de Auditoria de Qualidade de uma Seguradora de Saúde. Os dados foram obtidos por meio de observações não participantes, documentados descritivamente, ilustrados na forma de fluxogramas, validados pelos gerentes responsáveis pelos Departamentos de Auditoria da Seguradora e, posteriormente, por três enfermeiras juízas com ampla experiência em auditoria no Sistema de Saúde Suplementar.