bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does better access to finance help firms deal with the COVID‐19 pandemic? Evidence from firm‐level survey data
Authors: Amin Mohammad , Viganola Domenico 
Published: April 2023

AbstractThe impact of the firm's pre‐pandemic financial condition on the likelihood of a decline in its sales due to the COVID‐19 pandemic in 35 developing and emerging countries is estimated. Results show that better access to finance reduces the likelihood of a decline in sales. Access to finance is more effective in arresting sales declines when firms fear that production cuts may lead to the loss of skilled workers and hard‐to‐replace input suppliers. It is less effective when workers, like women, do not wish to continue working for health or family reasons. Important policy implications are discussed.
Vaccine cold chain in remote environments: culturally appropriate training opportunities, an evaluation
Authors: Belton Suzanne , Schultz Rosalie , Speare Tobias 
Published: April 2023

AbstractVaccines are temperature‐sensitive, and they may lose effectiveness without correct storage. Research in remote Australia raised questions regarding the integrity of the vaccine cold chain to Aboriginal communities and prompted the development of a video resource, Vaccine Story, to raise awareness of maintaining the cold chain. This study describes the development and evaluation of the Vaccine Story video. Local engagement helped to refine and produce the video. Ethics approval was gained from the Menzies School of Health Research Human Ethics Committee (20–3807) and the Central Australian Human Ethics Committee (17–2869) in 2020. The evaluation was considered low risk to all participants. An online anonymous survey tested the appropriateness and effectiveness of the Vaccine Story video to enhance knowledge and awareness of risks to the vaccine cold chain and the potential implementation of the Vaccine Story video. Diverse health professionals and other staff (n = 83) completed the survey. Responses highlighted a lack of training around the packing and transport of vaccines, particularly for non‐clinical support staff. Respondents stated the health messaging in the Vaccine Story video was effective. Over half of respondents (52%) recommend the use of the video as a training tool. The Vaccine Story video addresses some concerns regarding vaccine transportation and storage in remote Aboriginal communities through strengthening understanding of the importance of cold chain.
Improved Swelling Property of Tissue Adhesive Hydrogels Based on α‐Cyclodextrin/Decyl Group‐Modified Alaska Pollock Gelatin Inclusion Complexes
Authors: Komatsu Hiyori , Watanabe Shiharu , Ito Shima , Nagasaka Kazuhiro , Nishiguchi Akihiro , Taguchi Tetsushi 
Published: April 2023

AbstractAdhesives/sealants are used after suturing to prevent leakage of cerebrospinal fluid from an anastomotic site. Commercial adhesives/sealants have been used to close the cerebral dura. However, swelling of the cured adhesives/sealants induces increased intracranial pressure and decreases the strength of the seal. In the present study, tissue adhesive hydrogels with improved swelling property using inclusion complex composed of α‐cyclodextrin (αCD) and decyl group (C10)‐modified Alaska pollock‐derived gelatin (C10‐ApGltn) with a high degree of substitution (DS) (>20 mol%) are developed. Viscosity of C10‐ApGltn with a high DS solution remarkably decreased by the addition of αCD. The resulting αCD/C10‐ApGltn adhesive hydrogel composed of αCD/C10‐ApGltn inclusion complexes and poly(ethylene glycol) (PEG)‐based crosslinker showed improved swelling property after immersion in saline. Also, the resulting adhesive has a significantly higher burst strength than fibrin‐based adhesives and is as strong as a PEG‐based adhesive. Quantitative analysis of αCD revealed that the improved swelling property of the resulting adhesive hydrogels is induced by the release of αCD from cured adhesive, and the subsequent assembly of decyl groups in the saline. These results suggest that adhesives developed using the αCD/C10‐ApGltn inclusion complex can be useful for closing the cerebral dura mater.
Mass spectrometric approaches in discovering lipid biomarkers for COVID‐19 by lipidomics: Future challenges and perspectives
Authors: B. Gowda Siddabasave Gowda , Shekhar Chandra , Gowda Divyavani , Chen Yifan , Chiba Hitoshi , Hui Shu‐Ping 
Published: April 2023

AbstractCoronavirus disease 2019 (COVID‐19) has emerged as a global health threat and has rapidly spread worldwide. Significant changes in the lipid profile before and after COVID‐19 confirmed the significance of lipid metabolism in regulating the response to viral infection. Therefore, understanding the role of lipid metabolism may facilitate the development of new therapeutics for COVID‐19. Owing to their high sensitivity and accuracy, mass spectrometry (MS)‐based methods are widely used for rapidly identifying and quantifying of thousands of lipid species present in a small amount of sample. To enhance the capabilities of MS for the qualitative and quantitative analysis of lipids, different platforms have been combined to cover a wide range of lipidomes with high sensitivity, specificity, and accuracy. Currently, MS‐based technologies are being established as efficient methods for discovering potential diagnostic biomarkers for COVID‐19 and related diseases. As the lipidome of the host cell is drastically affected by the viral replication process, investigating lipid profile alterations in patients with COVID‐19 and targeting lipid metabolism pathways are considered to be crucial steps in host‐directed drug targeting to develop better therapeutic strategies. This review summarizes various MS‐based strategies that have been developed for lipidomic analyzes and biomarker discoveries to combat COVID‐19 by integrating various other potential approaches using different human samples. Furthermore, this review discusses the challenges in using MS technologies and future perspectives in terms of drug discovery and diagnosis of COVID‐19.
Effects of sponge‐to‐sponge contact on the microbiomes of three spatially competing Caribbean coral reef species
Authors: Gantt Shelby E. , Erwin Patrick M. 
Published: April 2023

AbstractSponges perform important ecosystem functions, host diverse microbial symbiont communities (microbiomes), and have been increasing in density on Caribbean coral reefs over the last decade. Sponges compete for space in coral reef communities through both morphological and allelopathic strategies, but no studies of microbiome impacts during these interactions have been conducted. Microbiome alterations mediate spatial competition in other coral reef invertebrates and may similarly impact competitive outcomes for sponges. In this study, we characterized the microbiomes of three common Caribbean sponges (Agelas tubulata, Iotrochota birotulata, and Xestospongia muta) observed to naturally interact spatially in Key Largo, Florida (USA). For each species, replicate samples were collected from sponges in contact with neighbors at the site of contact (contact) and distant from the site of contact (no contact), and from sponges spatially isolated from neighbors (control). Next‐generation amplicon sequencing (V4 region of 16S rRNA) revealed significant differences in microbial community structure and diversity among sponge species, but no significant effects were observed within sponge species across all contact states and competitor pairings, indicating no large community shifts in response to direct contact. At a finer scale, particular symbiont taxa (operational taxonomic units at 97% sequence identity, OTUs) were shown to decrease significantly in some interaction pairings, suggesting localized effects for specific sponge competitors. Overall, these results revealed that direct contact during spatial competition does not significantly alter microbial community composition or structure of interacting sponges, suggesting that allelopathic interactions and competitive outcomes are not mediated by microbiome damage or destabilization.
Maternal migraine and risk of pediatric cancers
Authors: Orimoloye Helen T. , Heck Julia E. , Charles Andrew , Saechao Chai , He Di , Federman Noah , Olsen Jorn , Ritz Beate , Hansen Johnni 
Published: April 2023

AbstractBackgroundMaternal migraine has been linked to adverse birth outcomes including low birth weight and preterm birth, as well as congenital anomalies in offspring. It has been speculated that this may be due to the use of medications in pregnancy, but lifestyle, genetic, hormonal, and neurochemical factors could also play a role. There is evidence for varying cancer incidences among adults with migraine. Here, we utilized data from national registries in Denmark to examine associations between maternal diagnoses of migraine and risk for cancer in offspring.MethodsWe linked several national registries in Denmark to identify cases from the Cancer Registry among children less than 20 years (diagnoses 1996–2016) and controls from the Central Population Register, matched to cases by birth year and sex (25:1 matching rate). Migraine diagnoses were identified from the National Patient Register using International Classification of Diseases, versions 8 and 10 codes and migraine‐specific acute or prophylactic treatment recorded in the National Pharmaceutical Register. We used logistic regression to estimate the risk of childhood cancers associated with maternal migraine.ResultsMaternal migraine was positively associated with risk for non‐Hodgkin lymphoma (odds ratio [OR] = 1.70, 95% confidence interval [CI]: 1.01–2.86), central nervous system tumors ([OR = 1.31, 95% CI: 1.02–1.68], particularly glioma [OR = 1.64, 95% CI: 1.12–2.40]), neuroblastoma (OR = 1.75, 95% CI: 1.00–3.08), and osteosarcoma (OR = 2.60, 95% CI: 1.18–5.76).ConclusionsAssociations with maternal migraine were observed for several childhood cancers, including neuronal tumors. Our findings raise questions about the role of lifestyle factors, sex hormones, genetic, and neurochemical factors in the relationship between migraine and childhood cancers.
Registration of ‘Georgia‐22MPR’ peanut
Authors: Branch W. D. , Brenneman T. B. 
Published: April 2023

Abstract‘Georgia‐22MPR’ (Reg. no. CV‐153, PI 702544) is a new high‐yielding, high‐oleic medium‐large‐seeded, runner‐type peanut (Arachis hypogaea L. subsp. hypogaea var. hypogaea) cultivar resistant to Tomato spotted wilt virus (TSWV), root‐knot nematode [RKN; Meloidogyne arenaria (Neal) Chitwood], and potato leafhopper (Empoasca fabae Harris). It was released by the Georgia Agricultural Experiment Station in 2022. Georgia‐22MPR was developed at the University of Georgia, Tifton Campus. It originated from the cross ‘Georgia Greener’ × GA 082524. Georgia Greener is a normal‐oleic, TSWV‐resistant, runner‐type peanut cultivar. GA 082524 is a high‐oleic, RKN‐resistant, advanced Georgia breeding line. Pedigree selection was practiced within the early segregating generations. Performance testing began in the F4:6 generation with the advanced pure‐line selection, GA 163120. During the past 4 years (2018–2021) averaged over 27 multiple location tests without nematode pressure in Georgia, Georgia‐22MPR had significantly less TSWV and total disease incidence than ‘Georgia‐14N’. Georgia‐22MPR was also found to have a larger runner seed size as compared to the smaller runner‐type check cultivar, Georgia‐14N. Georgia‐22MPR combines high yield, TSWV resistance, leafhopper insect resistance, and RKN resistance with medium–large seed size and the high‐oleic trait for longer shelf‐life and improved oil quality of peanut and peanut products.
Total body fluid is the factor that affects the pharmacokinetics of tolvaptan, and its efficacy, in acute worsening heart failure patients
Authors: Kato Takahiro , Yasuda Yoko , Okamoto Hitomi , Saito Yuji , Nakano Yusuke , Matsuura Katsuhiko , Oonishi Masafumi , Amano Tetsuya 
Published: April 2023

AbstractThe optimal starting dose of tolvaptan to effectively improve fluid retention in patients with heart failure (HF) is unknown. This study explored the factors affecting the pharmacokinetics (PKs) and pharmacodynamics of tolvaptan in patients with decompensated HF. We prospectively enrolled patients who were slated to receive tolvaptan because of volume overload associated with chronic HF. Blood samples were collected to measure tolvaptan concentrations before and 4, 8, 12–15, 24, and 144 h after administration. Additionally, demographic parameters, coadministered drugs, and body fluid composition were evaluated. Multiple regression analysis to detect PK parameters for the prediction of body weight (BW) loss at day 7 after the initiation of tolvaptan treatment and PK analysis to explore the factors affecting the PKs of tolvaptan were performed. In total, 165 blood samples were obtained from 37 patients. The predictors of weight loss on day 7 were area under the curve (AUC0–∞) of tolvaptan. PK analysis of the data revealed a strong correlation between CL/F and Vd/F, but no correlation between CL/F and kel (r = .95 and .06, respectively). A significant correlation was observed between total body fluid and Vd/F, and this correlation remained statistically significant even after adjusting for BW (r = .49, p < .05). Fat was also significantly correlated with Vd/F before adjusting for BW, on the other the correlation disappeared after adjusting BW. The optimal dose of tolvaptan based on total body fluid levels in individual patients could result in the alleviation of fluid retention in patients with HF.
Three‐port transoral robotic thyroidectomy without axillary incision: A preliminary report on a case series from Vietnam
Authors: Ngo Duy Quoc , Van Pham Binh , Ngo Quy Xuan , Van Le Quang 
Published: April 2023

AbstractBackgroundTransoral robotic thyroidectomy (TORT) is one of the newest approaches and draws attention because of its cosmetic excellence. Here, we present our preliminary data from the initial 5 consecutive patients to explore the feasibility of three‐port TORT without axillary incision.MethodsFrom August 2022 to December 2022, we performed TORT using three ports via the da Vinci Xi system with three robotic arms.ResultsAll 5 patients had cT1aN0M0 papillary thyroid carcinomas with a mean tumour size of 6 mm. All patients underwent lobectomy with ipsilateral central neck dissection. The mean surgical time was 170 ± 15,8 min; the average length of hospital stay is 4.2 days. The number of retrieved central lymph nodes was 4.2 ± 0.8. All patients were discharged uneventfully without complications and completely satisfied with the cosmetic results.ConclusionsTORT is feasible and safe when performed on carefully selected patients by experienced surgeons.
Father and Toddler Language During Shared Book Reading with Text‐Based and Wordless Picture Books
Authors: Conica Mirela , Kelly Linda , Nixon Elizabeth , Quigley Jean 
Published: April 2023

AbstractWhile the association between shared book reading (SBR) and child language development is well documented, there has been less focus on how book characteristics may differentially elicit parents' language input and hence differentially relate to children's language skills during this activity. Moreover, despite the positive and unique role that fathers have been shown to play for children's language, the father‐child SBR evidence base is small. Accordingly, the present study examined variation in father and child language quantity, quality, complexity, and function during SBR with text‐based and wordless picture books and explored associations between fathers' language and children's language during these episodes. Participants were 46 father‐child dyads (20 females). Fathers' mean age was 38.74 years (SD = 5.74), and children's mean age was 37.89 months (SD = 2.71). Findings indicate that fathers in the text‐book condition produced significantly greater language quality, extended the topic more, and produced more conversational utterances but described and labeled pictures less than fathers in the wordless picture book condition. Fathers' language during both SBR episodes showed differential links with child's language and may suggest that fathers were fine‐tuning their language in accordance with their child's language skills (effect sizes ranged from r = .45 to r = .78). It is possible that variation in book content may encourage different types of learning with distinct effects on different domains of child language. Should future research replicate such differential relations, findings may inform caretakers and early childhood interventions with the aim of promoting children's books tailored to specific language areas of interest.
Plant Leaf‐Inspired Separators with Hierarchical Structure and Exquisite Fluidic Channels for Dendrite‐Free Lithium Metal Batteries
Authors: Yang Yanfei , Wang Wankai , Li Meisheng , Zhou Shouyong , Zhang Junping , Wang Aiqin 
Published: April 2023

AbstractLithium (Li) metal batteries are among the most promising devices for high energy storage applications but suffer from severe and irregular Li dendrite growth. Here, it is demonstrated that the issue can be well tackled by precisely designing the leaf‐like membrane with hierarchical structure and exquisite fluidic channels. As a proof of concept, plant leaf‐inspired membrane (PLIM) separators are prepared using natural attapulgite nanorods. The PLIM separators feature super‐electrolyte‐philicity, high thermal stability and high ion‐selectivity. Thus, the separators can guide uniform and directed Li growth on the Li anode. The Li//PLIM//Li cell with limited Li anode shows high Coulombic efficiency and cycling stability over 1500 h with small overpotential and interface impedance. The Li//PLIM//S battery exhibits high initial capacity (1352 mAh g−1), cycling stability (0.019% capacity decay per cycle at 1 C over 500 cycles), rate performance (673 mAh g−1 at 4 C), and high operating temperature (65 °C). The separators can also effectively improve reversibility and cycling stability of the Li/Li cell and Li//LFP battery with carbonate‐based electrolyte. As such, this work provides fresh insights into the design of bioinspired separators for dendrite‐free metal batteries.
Bioengineering approaches for nerve graft revascularization: Current concepts and future directions
Authors: Pereira Clifford , Lazar Sabrina Valentina , Wang Aijun 
Published: April 2023

AbstractPeripheral nerve injury (PNI) is the most common neurological injury in civilian and military injuries, with over 360,000 PNI procedures performed in the US yearly. Segmental loss of nerve tissue results in a nerve gap precluding a tension‐free primary repair, and in these cases, interpositional autologous or acellular nerve allografts are used to bridge the gap. Graft ischemia time is a critical factor in achieving satisfactory nerve regeneration. Rapid nerve graft revascularization is essential in order to sustain Schwann cell growth which in turn is crucial for axonal regeneration. Currently, nerve autografts are considered the gold standard for segmental nerve gaps but are associated with several disadvantages such as limited supply of expendable donor tissue, increased operative time, and donor site morbidity. Hence, readily available, off‐the‐shelf nerve allografts or scaffolds are being investigated since they provide advantages such as a virtually limitless sourcing, a wide variety of sizes to match recipient nerves, and no donor site morbidity. New, exciting advances in tissue engineering to augment revascularization of nerve allografts or conduits have been investigated. Strategies include pro‐angiogenic mesenchymal stem cells, extracellular vesicles, functionalized scaffolds, bioactive peptides, and three‐dimensional bioprinting. This article discusses these bioengineering advances and future strategies aimed at enhancing nerve graft and scaffold revascularization.This article is categorized under:
Neurological Diseases > Biomedical Engineering
Neurological Diseases > Molecular and Cellular Physiology
A One Health approach to overcoming fungal disease and antifungal resistance
Authors: Woods Michael , McAlister Jason A. , Geddes‐McAlister Jennifer 
Published: April 2023

AbstractThe global burden of fungal disease poses a substantial threat to human, animal, and environmental health, endangering both human and livestock populations and creating vulnerabilities to food supplies world‐wide. Antifungal drugs provide essential therapies to humans and animals against infections, while fungicides provide protection in agriculture. However, a limited arsenal of antifungal agents results in cross‐use between agriculture and health, promoting the development of resistance, and drastically reducing our defenses against disease. Critically, antifungal resistant strains found ubiquitously within the natural environment demonstrate resistance to the same classes of antifungals used to treat human and animal infections, hindering effective treatment within the clinic. This interconnectivity supports the need for a One Health approach to combat fungal diseases and overcome antifungal resistance, ensuring that treatment and protection of a defined group does not inadvertently endanger or sacrifice other plants, animals, or humans. In this review, we present sources of antifungal resistance and discuss the integration of environmental and clinical resources to manage disease. Moreover, we explore opportunities for drug synergy and repurposing strategies, highlight fungal targets being investigated to overcome resistance, and propose technologies for the discovery of novel fungal targets.This article is categorized under:
Infectious Diseases > Molecular and Cellular Physiology
Numerical investigation for entropy‐based magneto nanofluid flow over non‐linear stretching surface with slip and convective boundary conditions
Authors: Babu Dondu Harish , Reddy Singamala Harinath , Naidu Kolla Kumaraswamy , Narayana Panyam Venkata Satya , Venkateswarlu Bhumarapu 
Published: April 2023

AbstractThe nanoliquid flows place a significant role in modern research due to the vast number of applications in the Food industry, manufacturing, thermal management, enhanced oil recovery, biomedical applications, and so on. This article presents the analysis of entropy generation on convective nanofluid flow in a three‐dimensional nonlinear stretching sheet with slip effects. Brownian motion and thermophoresis impacts are adopted by the nanoparticle concentration and temperature profiles. The PDEs are remodeled into ODEs by employing the appropriative simulated alternations, and the ODEs are solved by utilizing the R–K–F scheme along with the shooting technique. The main contributions of physical stream factors on the nanofluid concentration, heat, and speed profiles are displayed and explored via plots. Moreover, the rate of heat transfer and surface drag force are examined through tabular structures. In view of this, the nanofluids have more heat transfer capability and improve thermal properties. The slip factors are used in the boundary conditions of the velocity, and the limit conditions are utilized for the hotness and speed of the nanoparticles. The rate of heat transfer in a non‐linear stretching sheet is 1%–2% more than linear stretching sheet for varying values of Prandtl number Pr and Magnetic field M.