bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactions of genetic risks for autism and the broad autism phenotypes
Authors: Dong Lijie , Wang Yijing , Wang Xiaomeng , Luo Tengfei , Zhou Qiao , Zhao Guihu , Li Bin , Xia Lu , Xia Kun , Li Jinchen 
Published: March 2023

BackgroundCommon polygenic risk and de novo variants (DNVs) capture a small proportion of autism spectrum disorder (ASD) liability, and ASD phenotypic heterogeneity remains difficult to explain. Integrating multiple genetic factors contribute to clarifying the risk and clinical presentation of ASD.MethodsIn our study, we investigated the individual and combined effects of polygenic risk, damaging DNVs (including those in ASD risk genes), and sex among 2,591 ASD simplex families in the Simons Simplex Collection. We also explored the interactions among these factors, along with the broad autism phenotypes of ASD probands and their unaffected siblings. Finally, we combined the effects of polygenic risk, damaging DNVs in ASD risk genes, and sex to explain the total liability of ASD phenotypic spectrum.ResultsOur findings revealed that both polygenic risk and damaging DNVs contribute to an increased risk for ASD, with females exhibiting higher genetic burdens than males. ASD probands that carry damaging DNVs in ASD risk genes showed reduced polygenic risk. The effects of polygenic risk and damaging DNVs on autism broad phenotypes were inconsistent; probands with higher polygenic risk exhibited improvement in some behaviors, such as adaptive/cognitive behaviors, while those with damaging DNVs exhibited more severe phenotypes. Siblings with higher polygenic risk and damaging DNVs tended to have higher scores on broader autism phenotypes. Females exhibited more severe cognitive and behavioral problems compared to males among both ASD probands and siblings. The combination of polygenic risk, damaging DNVs in ASD risk genes, and sex explained 1–4% of the total liability of adaptive/cognitive behavior measurements.ConclusionOur study revealed that the risk for ASD and the autism broad phenotypes likely arises from a combination of common polygenic risk, damaging DNVs (including those in ASD risk genes), and sex.
Sarcopenia index based on serum creatinine and cystatin C is associated with mortality in middle-aged and older adults in Chinese: A retrospective cohort study from the China Health and Retirement Longitudinal Study
Authors: Wu Yang , Wang Hai , Tong Yingmu , Zhang Xing , Long Yunxiang , Li Qinglin , Ren Jie , Liu Chang 
Published: March 2023

BackgroundThe sarcopenia index (SI, serum creatinine/serum cystatin C × 100) is recommended for predicting sarcopenia. There were several studies showing that lower SI is associated with poorer outcomes in the older adults. However, the cohorts studied in these researches were mainly patients hospitalized. The aim of this study was to evaluate the correlation between SI and all-cause mortality among middle-aged and older adults from the China Health and Retirement Longitudinal Study (CHARLS).Materials and methodsA total of 8,328 participants meeting the criteria were enrolled in this study from CHARLS between 2011 and 2012. SI was calculated as [serum creatinine (mg/dL)/cystatin C (mg/L)] × 100. Mann-Whitney U-test and Fisher's exact test were used to assess balance in baseline characteristics. Kaplan-Meier, log-rang analysis, univariate and multivariate Cox hazard ratio regression models were used to compare the mortality between different SI levels. The dose relationship between sarcopenia index and all-cause mortality was further assessed by the cubic spline functions and smooth curve fitting.ResultsAfter adjustment for potential covariates, we found SI was significantly correlated with all-cause mortality [Hazard Ratio (HR) = 0.983, 95% confidence interval (CI) 0.977–0.988, P &lt; 0.001]. Similarly, as SI was used as a categorical variable according to quartiles, higher SI was associated with lower mortality [Hazard Ratio (HR) = 0.44, 95% CI 0.34–0.57, P &lt; 0.001] after adjustment for confounders.ConclusionsLower sarcopenia index was associated with higher mortality among middle-aged and older adults in China.
Effectiveness of video self-instruction training on cardiopulmonary resuscitation retention of knowledge and skills among nurses in north-western Nigeria
Authors: Saidu Ahmed , Lee Khuan , Ismail Iskasymar , Arulogun Oyedunni , Lim Poh Ying 
Published: March 2023

BackgroundAdaptable cardiopulmonary resuscitation/basic life support (CPR/BLS) training are required to reduce cardiac arrest mortality globally, especially among nurses. Thus, this study aims to compared CPR knowledge and skills retention level between instructor-led (control group) and video self-instruction training (intervention group) among nurses in northwestern Nigeria.MethodsA two-arm randomized controlled trial study using double blinding method was conducted with 150 nurses from two referral hospitals. Stratified simple random method was used to choose eligible nurses. For video self-instruction training (intervention group), participants learnt the CPR training via computer in a simulation lab for 7 days, in their own available time whereas for instructor-led training (control group), a 1-day program was conducted by AHA certified instructors. A generalized estimated equation model was used for statistical analysis.ResultsGeneralized Estimated Equation showed that there were no significant differences between the intervention group (p = 0.055) and control group (p = 0.121) for both CPR knowledge and skills levels respectively, whereas higher probability of having good knowledge and skills in a post-test, one month and three-month follow-up compared to baseline respectively, adjusted with covariates (p &lt; 0.05). Participants had a lower probability of having good skills at 6-month follow-up compared to baseline, adjusted with covariates (p = 0.003).ConclusionThis study showed no significant differences between the two training methods, hence video self-instruction training is suggested can train more nurses in a less cost-effective manner to maximize resource utilization and quality nursing care. It is suggested to be used to improve knowledge and skills among nurses to ensure cardiac arrest patients receive excellent resuscitation care.
Ovine gastrointestinal parasite burden and the impact of strategic anthelmintic treatment in community-based breeding sites in Ethiopia
Authors: Molla Wassie , Moliso Mesfin Mekonnen , Gizaw Solomon , Nane Tesfalem , Arke Asrat , Ayele Firdawok , Knight-Jones Theodore 
Published: March 2023

IntroductionIn Ethiopia, small ruminants contribute significantly to livelihoods and food security but productivity is low with high disease burden and essential endoparasite control not widely practiced. The current study assessed worm burden and its control in three districts in Ethiopia.MethodsAll sheep older than 3 months in nine villages were treated en-masse with albendazole and triclabendazole twice a year from 2018 to 2021. Treatments were administered under field conditions by animal health workers. Pre- and post-treatment data were assessed looking at fecal egg presence/absence and fecal egg per gram (EPG) count.ResultsA total of 1,928 and 735 sheep were examined before and after deworming, respectively. Before treatment worms were detected in 54.4% (95% CI: 52.2–56.6) of sheep. Strongylid (30.4%) and Fasciola (18.2%) were the most frequently identified parasites. Animals living in wet mid-highland environments were more than 23 times more likely to have strongylid eggs in their feces and 5 times more likely to have eggs from any gastrointestinal tract (GIT) parasites detected, as compared to animals living in moist highland agro-ecology. Over the course of the 2018–2021 community intervention there was total elimination of animals with a high worm burden (EPG &gt; 1,500), and elimination of a third of those with moderate infections. Mild infections remained, largely accounted for by strongylid, which remains at low levels in healthy sheep. However, there were signs of emerging drug resistance.ConclusionGenerally, sheep in smallholder systems in Ethiopia experience a needlessly large economic burden from GIT worms. Routine therapy reduces this burden but smart strategies are needed to limit the onset of drug resistance.
Part A: Biodegradable Bio-Composite Film Reinforced with Cellulose Nanocrystals from Chaetomorpha linum into Thermoplastic Starch Matrices
Authors: Alsufyani Taghreed , M’sakni Nour Houda 
Published: March 2023

In recent years, macroalgae and microalgae have played a significant role in the production of organic matter, fiber, and minerals on Earth. They contribute to both technical and medicinal applications as well as being a healthy and nutritious food for humans and animals. The theme of this work concerns the development and exploitation of Chaetomorpha linum (C. linum) biomass, through the elaboration of a new starch-based composite film reinforced by cellulose nanocrystals (CL-CNC) derived from C. linum. The first step involves the chemical extraction of CL-CNC from dry C. linum algae biomass. To achieve this, three types of cyclic treatment were adopted: alkalinization (sodium hydroxide) followed by bleaching (sodium hypochlorite) and acid hydrolysis (hydrochloric acid). We then studied the optimization of the development of bio-composite films based on corn starch (CS) reinforced by CL-CNC. These polymeric films were produced using the solution-casting technique followed by the thermal evaporation process. Structure and interactions were modified by using different amounts of glycerol plasticizers (20% and 50%) and different CS:CNC ratios (7:3 and 8:2). These materials were characterized by UV visible (UV/Vis), Fourier Transform Infrared (FTIR) and Scanning Electron Microscope (SEM) spectroscopy to understand structure-property relationships. The result revealed that the best matrix composition is 7:3 (CS: CL-CNC) with 50% glycerol, which reflects that the reinforcing effect of CL-CNC was greater in bio-composites prepared with a 50% plasticizer, revealing the formation of hydrogen bonds between CL-CNC and CS.
Uma analise da obra Canon Doctrinae Triangulorum (1551) de Georg Joachim Rheticus (1514 – 1574)
Authors: Paulo Stephany Glaucia de Oliveira , Brandemberg João Cláudio 
Published: March 2023

O interesse pelo tema, história da Trigonometria, surgiu a partir de nossas leituras, realizadas no Grupo de Estudos e Pesquisa em História e Ensino de Matemática (GEHEM), onde comentamos, inicialmente, a obra Canon Doctrinae Triangulorum (1551) publicado pelo matemático austríaco Georg Joachim Rheticus (1514 – 1574), tal obra nos apresenta tabelas trigonométricas construídas (calculadas) a partir de relações entre os lados de triângulos retângulos, contendo os valores de seno, cosseno, tangente, cossecante, secante e cotangente para ângulos (inclinações) de 10 em 10 minutos. Uma observação mais efetiva dessas tabelas nos infere, que podem contribuir para o processo de ensino e aprendizagem das razões trigonométricas para a Educação Básica. No intuito de maior esclarecimento, de sua produção, visamos responder a seguinte questão de pesquisa: Como se deu a construção das tabelas trigonométricas contidas no Canon Doutrinae Triangulorum (1551)? Logo, nosso objetivo neste artigo é investigar a construção das tabelas trigonométricas contidas no Canon Doctrinae Triangulorum. Para responder nossa questão de pesquisa realizamos uma viagem histórica pelas ideias que Rheticus utilizou para a construção das tabelas trigonométricas contida em seu Canon, que nos apresenta uma evolução, em relação a outras tabelas existentes, a partir de seus estudos influenciados por Copérnico. De acordo com a nossa investigação concluímos que, somente uma observação das tabelas contidas no Canon não oferece suporte suficiente para identificarmos, detalhes de como os valores registrados nas tabelas foram calculados, então recorremos a outras referências em História da Matemática que nos forneceram informações importantes para entendermos: como aqueles valores foram obtidos, através das relações entre os lados de triângulos, e da importância que o Canon teve em sua época e para o desenvolvimento da Trigonometria.
Analisis Kontribusi Pola Asuh Orang Tua Dan Bimbingan Guru Terhadap Perilaku Sosial Anak Usia Dini Di Taman Kanak-Kanak Kapupaten Paniai, Provinsi Papua
Authors: Tenouye Deni , Hamid Sundari , Hamsiah Andi 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui bagaimana kontribusi peran pola asuh orang tua terhadap perilaku sosial anak usia dini di taman kanak-kanak Kabupaten Paniai Papua dan mendeskripsikan bimbingan guru terhadap perilaku sosial anak usia dini di Taman Kanak-Kanak Kabupaten Paniai Papua. Jenis penelitian yang digunakan adalah jenis penelitian ex post facto. Variabel yang digunakan dalam penelitian ini terdiri dari variabel bebas dan variabel terikat. Variabel bebas terdiri dari pola asuh orang tua dan bimbingan guru sedangkan variabel terikat terdiri dari perilaku sosial. Populasi penelitian yaitu jumlah keseluruhan. Sampel penelitian adalah berjumlah 21 anak usia dini, Teknik pengambilan sampel pada penelitian ini adalah dengan menggunakan teknik Purposive Sampling. Hasil penelitian menunjukkan terdapat kontribusi peran pola asuh orang tua terhadap perilaku sosial anak usia dini di taman kanak-kanak Kabupaten Paniai Papua. Terdapat bimbingan guru terhadap perilaku sosial anak usia dini di Taman Kanak-Kanak Kabupaten Paniai Papua.
The research aims to this study aims to find out how the role of parenting parents contributes to the social behavior of early childhood in Kindergarten in Paniai Regency, Papua. And describe teacher guidance on early childhood social behavior in Kindergartens, Paniai Regency, Papua. The type of research used is the type of ex post facto research. The variables used in this study consisted of independent variables and dependent variables. The independent variable consists of parenting and teacher guidance, while the variable consists of social behavior. The research population is the total number. The research sample was 21 early childhood. The sampling technique in this study was using the purposive sampling technique. The results showed the contribution of the role of parenting to the social behavior of early childhood in the Kindergarten of Paniai Regency, Papua. There is teacher guidance on the social behavior of early childhood in the Kindergarten of Paniai Regency, Papua.
Strategi Pengembangan Agribisnis Sereh Wangi Di Desa Pasir Putih Kecamatan Sumarorong Kabupaten Mamasa Provinsi Sulawesi Barat
Authors: Oktavia Wildia , Salam Suryawati , Sheyoputri Aylee Christine Alamsyah , Abri Abri 
Published: March 2023

Sereh Wangi merupakan tanaman yang dapat menghasilkan minyak atsiri yang dikenal dengan nama citronella oil. Penelitian ini bertujuan untuk mengetahui faktor internal dan faktor eksternal serta merumuskan alternatif strategi pengembangan agribisnis sereh wangi. Penelitian ini dilaksanakan bulan April-Mei 2022, di Desa Pasir Putih. Metode analisis yang digunakan adalah SWOT. Hasil penelitian ini menunjukkan yaitu faktor internal meliputi kekuatan (antusias masyarakat membudidayakan sereh wangi; luas lahan tersedia; kondisi iklim mendukung; peluang pasar) dan kelemahan (lahan sebagaian berpasir; alat penyulingan manual; tenaga kerja kurang terampil). Faktor eksternal meliputi peluang (pertama kali dikembangkan di Kabupaten Mamasa; tanaman sereh wangi tahan terhadap hama dan penyakit; dukungan pemerintah; permintaan pasar tinggi) dan ancaman (harga berfluktuasi; kondisi pandemic membatasi sosialisasi; lahan sebagian berpasir). Analisis faktor strategi internal IFAS, diperoleh total skor sebesar 2,85. Sementara analisis faktor strategi eksternal EFAS diperoleh total skor sebesar 2,48. Strategi pengembangan sereh wangi yang paling tepat untuk diterapkan di Desa Pasir Putih, Kecamatan Sumarorong, Kabupaten Mamasa adalah strategi SO.
Lemongrass is a plant that can produce essential oils known as citronella oil. This study aims to determine internal and external factors and to formulate alternative strategies for developing lemongrass agribusiness. This research was conducted in April-May 2022, in the village of Pasir Putih. The analytical method used is SWOT. The results of this study indicate that internal factors include strengths (Community enthusiasm for cultivating lemongrass; available land area; favorable climatic conditions; market opportunities) and weaknesses (partially sandy land; manual distillation equipment; unskilled labor). External factors include opportunities (first developed in Mamasa District; lemongrass plants are resistant to pests and diseases; government support; high market demand) and threats (fluctuating prices; pandemic conditions limit socialization; land is partially sandy). IFAS internal strategy factor analysis, obtained a total score of 2.85. Meanwhile, EFAS's external strategy factor analysis obtained a total score of 2.48. The most appropriate strategy for developing lemongrass is the SO strategy.
ANALISIS SISTEM PENGELOLAAN DALAM MENINGKATKAN MUTU PENDIDIKANDI KABUPATEN MAROS
Authors: Abdullah Sitti Azzahrah , Yunus Muh. Kafrawi , Setiawan Lukman 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui dan menganalisis bagaimana sistem pengelolaan pendidikan di Kabupaten Maros dan untuk mengetahui dan menganalisis kendala-kendala sistem pengelolaan pendidikan di Kabupaten Maros. Responden dalam penelitian ini ialah kepala dinas pendidikan Kabupaten Maros, pengawas SMP dinas pendidikan Kabupaten Maros, pengawas SD dinas pendidikan Kabupaten Maros, kepala sekolah SMP dan SD, serta guru SMP dan SD Kabupaten Maros. Penelitian ini menggunakan metode penelitian deskriptif kualitatif. Hasil analisis menunjukkan bahwa komunikasi yang baik antara stakeholder kependidikan mengenai kebijakan dan sistem harus berjalan dengan baik sebelum diterapkan di sekolah-sekolah, pengelolaan pendidikan membutuhkan SDM yang berkompotensi pada bidang kependidikan dan Sarana dan prasarana memiliki peran penting dalam proses pembelajaran siswa.
This study aims to determine and analyze how the education management system in Maros and to identify and analyze the constraints of the education management system in Maros. Respondents in this study were the head of the Maros Education Service, the Middle School Supervisor of Maros Education Service, the Supervisor of Maros Elementary School, the Middle and Elementary School Principals, the Middle and Elementary School teachers in Maros. This research uses descriptive qualitative research method. The results of the analysis show that good communication between educational stakeholders regarding policies and systems must run well before being implemented in schools, education management requires competent human resources in the field of education and facilities and infrastructure have an important role in the student learning process.
PENGARUH IKLAN DAN BRAND IMAGE TERHADAP MINAT BELI KONSUMEN DENGAN BRAND TRUST SEBAGAI VARIABEL INTERVENING
Authors: Nasrullah Muh , Remmang Hasanuddin , Chahyono Chahyono 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui dan menganalisa pengaruh dari iklan, brand image, brand trust, terhadap minat beli konsumen untuk produk kendaraan yang dipasarkan oleh Kalla Toyota Penelitian ini termasuk dalam jenis penelitian survei yang bersifat kuantitatif. Jumlah sampel yang ditentukan sebanyak 100 responden. Metode pengumpulan data pada penelitian ini menggunakan kuesioner. Data yang telah dikumpulkan kemudian dianalisis menggunakan metode uji t dan path analysis. Hasil penelitian ini ditemukan bahwa iklan berpengaruh positif namun tidak signifikan baik terhadap Brand Trust ataupun minat beli konsumen berdasarkan uji t yang dilakukan. Selanjutnya untuk Brand Image ditemukan bahwa terdapat pengaruh signifikan terhadap Brand Trust namun terhadap minat beli konsumen tidak ditemukan pengaruh yang signifikan. Hasil uji t selanjutnya untuk Brand Trust terhadap minat beli konsumen ditemukan pengaruh yang signifikan. Untuk pengujian path analysis menunjukkan adanya pengaruh positif dari Iklan terhadap Minat Beli Konsumen melalui Brand Trust berdasarkan perhitungan total effect yang dihasilkan. Pengujian terakhir menunjukkan adanya pengaruh positif dari Brand Image terhadap Minat Beli Konsumen melalui variabel Brand Trust.
This study aims to investigates the effect of social media advertising, Brand Image and also Brand Trust through consumer buying interest. This study put in category as survey research with a quantitative approach. The number of samples in this study are 100 and as a follower of Kalla Toyota’s Instagram. The data collection method in this study used a questionnaire. The data that has been collected is then analyzed using the t test and path analysis method. Results from a between subject study indicate that there is a positive effect between social media advertising to Brand Trust but not significant and also to consumer buying interest. Furthermore, based on t test there is a positive and significant effect between Brand Image and Brand Trust but other results found that there is no significant influence between Brand Image and consumer buying effect. Moreover, path analysis result indicates that there is positive effect between social media advertising and consumer buying interest through Brand Trust based on test and total effect result. The same test result from other variables also indicates that there is also a positive effect between Brand Image and consumer buying interest through Brand Trust from total effect result.