bluuebunny/crossref_metadata_2025_split huggingface dataset:
Letter: Mendelian randomization ‐ new perspective in inflammatory bowel disease and pancreatic cancer? Authors' reply
Authors: Massironi Sara , Viganò Chiara , Danese Silvio 
Published: June 2023

LINKED CONTENTThis article is linked to Massironi et al papers. To view these articles, visit https://doi.org/10.1111/apt.16949 and https://doi.org/10.1111/apt.17537
Letter: determining priorities for patients with faecal incontinence and irritable bowel syndrome—authors' reply
Authors: Goodoory Vivek C. , Ng Cho E. , Black Christopher J. , Ford Alexander C. 
Published: June 2023

LINKED CONTENTThis article is linked to Goodoory et al papers. To view these articles, visit https://doi.org/10.1111/apt.17465 and https://doi.org/10.1111/apt.17559
Creative therapy in health and disease: Inner vision
Authors: Khalil Radwa , Demarin Vida 
Published: June 2023

AbstractCan we better understand the unique mechanisms of de novo abilities in light of our current knowledge of the psychological and neuroscientific literature on creativity? This review outlines the state‐of‐the‐art in the neuroscience of creativity and points out crucial aspects that still demand further exploration, such as brain plasticity. The progressive development of current neuroscience research on creativity presents a multitude of prospects and potentials for furnishing efficacious therapy in the context of health and illness. Therefore, we discuss directions for future studies, identifying a focus on pinpointing the neglected beneficial practices for creative therapy. We emphasize the neglected neuroscience perspective of creativity on health and disease and how creative therapy could offer limitless possibilities to improve our well‐being and give hope to patients with neurodegenerative diseases to compensate for their brain injuries and cognitive impairments by expressing their hidden creativity.
Residual osteomyelitis at the resection margin after conservative surgery is not associated with the recurrence of diabetic foot infection and may successfully be treated without postoperative antibiotic therapy
Authors: Aragón‐Sánchez Javier , Víquez‐Molina Gerardo , López‐Valverde María Eugenia , Rojas‐Bonilla José María , Segura‐Retana Elvira 
Published: June 2023

AbstractAimsWe hypothesize that microbiology‐ and pathology‐confirmed positive bone margins after the resection of diabetes‐related foot osteomyelitis are associated with worse outcomes.MethodsWe conducted a prospective study consisting of a cohort of 93 patients with diabetes‐related foot osteomyelitis (histopathology confirmed) who underwent bone resection and where an additional bone biopsy was taken at the resection margin. The primary outcome was the recurrence of the infection.ResultsPathology‐confirmed positive margins were detected in 62 cases (66.7%), microbiology‐confirmed positive margins were detected in 75 cases (80.6%) and recurrence was detected in 19 patients (20.4%). Chi‐squared test failed to show the presence of an association between the recurrence of the infection with pathology‐confirmed positive margins (p = 0.82), with microbiology‐confirmed positive margins, (p = 0.34) and with the use of postoperative antibiotics (p = 0.70). Healing in patients with pathology‐confirmed positive margins was achieved in a median of 12 weeks (95% CI 9.2‐18) and those with pathology‐confirmed negative margins in 14.9 weeks (95% CI 10.2‐21.9), Log‐rank test, p = 0.74. Thirty‐four patients out of 61 available for follow‐up (55.7%) with pathology‐confirmed positive margins were treated without postoperative antibiotics. In that group, Chi‐squared test failed to show the presence of an association between the recurrence of the infection with the use of postoperative antibiotics (p = 0.47).ConclusionsA positive margin was neither associated with the recurrence of the infection nor with the time to healing. More than half of patients with pathology‐confirmed positive margins were treated without postoperative antibiotics and this approach was not associated with the recurrence of the infection.
Reported neurological symptoms after severe acute respiratory syndrome coronavirus type 2 infection: A systematic diagnostic approach
Authors: Ludwig Birgit , Deckert Matthias , Krajnc Nik , Keritam Omar , Macher Stefan , Bsteh Gabriel , Zulehner Gudrun , Thurnher Majda , Berger Thomas , Seidel Stefan , Willinger Ulrike , Rommer Paulus 
Published: June 2023

AbstractBackground and purposeFollowing increasing demands of patients with suspected neurological symptoms after infection with severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2), the Department of Neurology at the Medical University of Vienna established a new outpatient clinic to systematically assess, diagnose, and document neurological complaints potentially associated with a prior SARS‐CoV‐2 infection.MethodsThe data presented here include prospectively collected 156 outpatients from May 2021 to April 2022. Patients underwent semistandardized interviewing about symptoms with reported onset after SARS‐CoV‐2 infection, neurological examination, and comprehensive diagnostic workup.ResultsReported new onset symptoms after infection included fatigue (77.6%), subjective cognitive impairment (72.4%), headache (47.7%), loss of smell and/or taste (43.2%), and sleep disturbances (42.2%). Most patients had a mild coronavirus disease (COVID‐19) disease course (84%) and reported comorbidities (71%), of which the most frequent were psychiatric disorders (34%). Frequency of symptoms was not associated with age, sex, or severity of COVID‐19 course. A comprehensive diagnostic workup revealed no neurological abnormalities in the clinical examination, or electrophysiological or imaging assessments in the majority of patients (n = 143, 91.7%). Neuropsychological assessment of a subgroup of patients (n = 28, 17.9%) showed that cognitive impairments in executive functions and attention, anxiety, depression, and somatization symptoms were highly common.ConclusionsIn this systematic registry, we identified fatigue, cognitive impairment, and headache as the most frequently reported persisting complaints after SARS‐CoV‐2 infection. Structural neurological findings were rare. We also suspect a link between the growing burden of the COVID‐19 pandemic on personal lives and the increase in reported neurological and psychiatric complaints.
Wherever I may roam—Human activity alters movements of red deer (Cervus elaphus) and elk (Cervus canadensis) across two continents
Authors: Mumme Steffen , Middleton Arthur D. , Ciucci Paolo , De Groeve Johannes , Corradini Andrea , Aikens Ellen O. , Ossi Federico , Atwood Paul , Balkenhol Niko , Cole Eric K. , Debeffe Lucie , Dewey Sarah R. , Fischer Claude , Gude Justin , Heurich Marco , Hurley Mark A. , Jarnemo Anders , Kauffman Matthew J. , Licoppe Alain , van Loon Emiel , McWhirter Doug , Mong Tony W. , Pedrotti Luca , Morellet Nicolas , Mysterud Atle , Peters Wibke , Proffitt Kelly , Saïd Sonia , Signer Johannes , Sunde Peter , Starý Martin , Cagnacci Francesca 
Published: June 2023

AbstractHuman activity and associated landscape modifications alter the movements of animals with consequences for populations and ecosystems worldwide. Species performing long‐distance movements are thought to be particularly sensitive to human impact. Despite the increasing anthropogenic pressure, it remains challenging to understand and predict animals' responses to human activity. Here we address this knowledge gap using 1206 Global Positioning System movement trajectories of 815 individuals from 14 red deer (Cervus elaphus) and 14 elk (Cervus canadensis) populations spanning wide environmental gradients, namely the latitudinal range from the Alps to Scandinavia in Europe, and the Greater Yellowstone Ecosystem in North America. We measured individual‐level movements relative to the environmental context, or movement expression, using the standardized metric Intensity of Use, reflecting both the directionality and extent of movements. We expected movement expression to be affected by resource (Normalized Difference Vegetation Index, NDVI) predictability and topography, but those factors to be superseded by human impact. Red deer and elk movement expression varied along a continuum, from highly segmented trajectories over relatively small areas (high intensity of use), to directed transitions through restricted corridors (low intensity of use). Human activity (Human Footprint Index, HFI) was the strongest driver of movement expression, with a steep increase in Intensity of Use as HFI increased, but only until a threshold was reached. After exceeding this level of impact, the Intensity of Use remained unchanged. These results indicate the overall sensitivity of Cervus movement expression to human activity and suggest a limitation of plastic responses under high human pressure, despite the species also occurring in human‐dominated landscapes. Our work represents the first comparison of metric‐based movement expression across widely distributed populations of a deer genus, contributing to the understanding and prediction of animals' responses to human activity.
Policy experimentation within flood risk management: Transition pathways in Austria
Authors: Thaler Thomas , Penning‐Rowsell Edmund C. 
Published: June 2023

AbstractFlood risk management (FRM) is facing various challenges, such as climate change and biodiversity losses. Traditional structural FRM measures are now not always feasible as responses to these challenges. One answer might be the use of policy experiments to promote innovation. This paper aims to assess and to explain why innovations in FRM are rarely implemented. We analysed seven innovative strategies across Austria that combine several different approaches. Each is concerned with risk reduction systems designed to save space, time and possible rising costs. The research used 76 qualitative standardised semi‐structured interviews with key FRM experts conducted between 2012 and 2021 in order to examine transition pathways through time. The results show that there exist numerous drivers and barriers to debating, designing and implementing FRM innovations. The capture of transition pathways nevertheless shows the system shift from a more traditional understanding towards a transformative path, which created new understandings of the role of the different actors in FRM as well as new institutional settings. However, these policy experiments were still led by the relevant public administrations as they are the main funders, the principal actors in the planning and implementation phases in the realisation of many of these innovations.
Divine Providence through Predictable Chance Events: A Problem for Non‐Competitive Accounts of Divine Action
Authors: Reeves Josh 
Published: June 2023

AbstractThis article addresses the question, ‘How can divine providence be reconciled with statistically random events?’ To limit the scope of the article, I focus on one popular version of meticulous providence that relies upon the primary/secondary causation distinction, influentially defended by Kathryn Tanner and her book God and Creation in Christian Theology. I argue that modern conceptions of chance and probability have made it more difficult to interpret chance events as part of God's meticulous providence since divine intentions in nature are expressed in ways that remove evidence of their purpose. The difficulty for meticulous providence is not that some events seem too random to be reconciled to God's providence, but rather the opposite: chance events do not have specific purpose behind them because they are predictable. I conclude that any satisfactory theological response to the problem of randomness necessitates a robust account of general providence that cannot be reduced to special providence.
Yesterday is history, tomorrow is a mystery: Directors’ and CEOs’ prior bankruptcy experiences and the financial risk of their current firms
Authors: Ivanova Mariya N. , Nilsson Henrik , Tylaite Milda 
Published: June 2023

AbstractUsing a large sample of Swedish private firms, we investigate the link between the prior corporate bankruptcy experiences (BEs) of directors and CEOs and the financial risk of their current firms. We find that firms with directors and CEOs previously involved in bankruptcies exhibit more aggressive corporate financial policies, have a higher corporate bankruptcy risk and are subject to a higher cost of debt. Our findings align with an innate characteristics explanation: corporate BEs and current corporate risk‐taking reflect personal risk preferences. Furthermore, while we find evidence of income losses for CEOs and directors involved in bankruptcies, such losses are transient, potentially explaining the risk‐taking behavior after experiencing bankruptcy. Overall, our results suggest that the presence of individuals with prior BE can be considered a signal of higher financial risk for their firms. This insight is relevant to regulators, lenders and corporate decision‐makers.
Reference gene recommendations and PACAP receptor expression in murine sympathetic ganglia of the autonomic nervous system that innervate adipose tissues after chronic cold exposure
Authors: Pandher Parleen K. , Rahim Yamna , Timms Katherine P. , Filatov Ekaterina , Short Landon I. , Gray Sarah L. 
Published: June 2023

AbstractPituitary adenylate cyclase‐activating polypeptide (PACAP) is an important regulator of the stress response in mammals, influencing both the hypothalamic–pituitary–adrenal (HPA) axis and the sympathetic nervous system (SNS). PACAP has been reported to influence energy homeostasis, including adaptive thermogenesis, an energy burning process in adipose tissue regulated by the SNS in response to cold stress and overfeeding. While research suggests PACAP acts centrally at the level of the hypothalamus, knowledge of PACAP's role within the sympathetic nerves innervating adipose tissues in response to metabolic stressors is limited. This work shows, for the first time, gene expression of PACAP receptors in stellate ganglia and highlights some differential expression with housing temperature. Additionally, we present our dissection protocol, analysis of tyrosine hydroxylase gene expression as a molecular biomarker for catecholamine producing tissue and recommend three stable reference genes for the normalization of quantitative real time‐polymerase chain reaction (qRT‐PCR) data when working with this tissue. This study adds to information about neuropeptide receptor expression in peripheral ganglia of the sympathetic nervous system innervating adipose tissue and provides insight into PACAP's role in the regulation of energy metabolism.
Social support and oral health among working‐age and older adults in the United States
Authors: Laniado Nadia , Cloidt Megan , Shah Parth 
Published: June 2023

AbstractObjectivesThe purpose of this study was to examine the association of social support with untreated dental caries and severe tooth loss in adults in the United States.MethodsThis cross‐sectional study was conducted by analyzing data obtained from 5,447 individuals, 40 years of age and older, in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2008 who had both a complete dental examination and social support index measures. Sample characteristics, overall and by social support level, were examined through descriptive statistical analyses. Logistic regression analyses were performed to estimate the association of social support with untreated dental caries and severe tooth loss.ResultsIn this nationally representative sample (mean age 56.5 years) the prevalence of low social support was 27.5%. The prevalence of individuals with moderate‐to‐high social support increased with higher levels of educational attainment and income level. In fully adjusted models, relative to those who had moderate‐high social support levels, individuals with low social support had 1.49 higher odds of untreated dental caries (95% CI, 1.17‐1.90, p=0.002) and 1.23 higher odds of severe tooth loss (95% CI, 1.05‐1.44, p=0.011).ConclusionsHigher odds of untreated dental caries and severe tooth loss were found among U.S. adults with low levels of social support compared to those with moderate‐to‐high levels of social support. Additional studies are warranted to provide a more current perspective on the impact of social support on oral health so that programs may be developed and tailored to reach these populations.
Philosophy as a thief?
Authors: Auxier Randall 
Published: June 2023

AbstractThis is a performative piece of writing in the presence of and inspired by Richard Shusterman'sPhilosophy and the Art of Writing. It tries to show that the relationship between the act of writing and the formation of our human consciousness (philosophical and, more deeply, poietic) is a developing and growing process through history, and before it. The dominance of an image consciousness was slowly challenged and then replaced by a linguistic consciousness with the advent of writing, and accelerated by the invention of printing and mass literacy. Shusterman teaches us an embodied kind of philosophizing that uses the word but isn't limited by it. This paper suggests that a return to image consciousness has already occurred and that the old book consciousness is disappearing. Lessons from the book consciousness are offered.
Arabidopsis Topless‐related 1 mitigates physiological damage and growth penalties of induced immunity
Authors: Griebel Thomas , Lapin Dmitry , Locci Federica , Kracher Barbara , Bautor Jaqueline , Concia Lorenzo , Benhamed Moussa , Parker Jane E. 
Published: June 2023

Summary
Transcriptional corepressors of the Topless (TPL) family regulate plant hormone and immunity signaling. The lack of a genome‐wide profile of their chromatin associations limits understanding of the TPL family roles in transcriptional regulation.
Chromatin immunoprecipitation with sequencing (ChIP‐Seq) was performed on Arabidopsis thaliana lines expressing GFP‐tagged Topless‐related 1 (TPR1‐GFP) with and without constitutive immunity via Enhanced Disease Susceptibility 1 (EDS1). RNA‐Seq profiling of the TPR1‐GFP lines and pathogen‐infected tpl/tpr mutants, combined with measuring immunity, growth, and physiological parameters was employed to investigate TPL/TPR roles in immunity and defense homeostasis.
TPR1 was enriched at promoter regions of c. 1400 genes and c. 10% of the detected binding required EDS1 immunity signaling. In a tpr1 tpl tpr4 (t3) mutant, resistance to bacteria was slightly compromised, and defense‐related transcriptional reprogramming was weakly reduced or enhanced, respectively, at early (< 1 h) and late 24 h stages of bacterial infection. The t3 plants challenged with bacteria or pathogen‐associated molecular pattern nlp24 displayed photosystem II dysfunctions. Also, t3 plants were hypersensitive to phytocytokine pep1 at the level of root growth inhibition. Transgenic expression of TPR1 rescued these t3 physiological defects.
We propose that TPR1 and TPL family proteins function in Arabidopsis to reduce detrimental effects associated with activated transcriptional immunity.
Revisiting yield in terms of phloem transport to grains suggests phloem sap movement might be homeostatic
Authors: Tcherkez Guillaume , Holloway‐Phillips Meisha , Lothier Jérémy , Limami Anis , Ball Marilyn C. 
Published: June 2023

AbstractPhloem sap transport, velocity and allocation have been proposed to play a role in physiological limitations of crop yield, along with photosynthetic activity or water use efficiency. Although there is clear evidence that carbon allocation to grains effectively drives yield in cereals like wheat (as reflected by the harvest index), the influence of phloem transport rate and velocity is less clear. Here, we took advantage of previously published data on yield, respiration, carbon isotope composition, nitrogen content and water consumption in winter wheat cultivars grown across several sites with or without irrigation, to express grain production in terms of phloem sucrose transport and compare with xylem water transport. Our results suggest that phloem sucrose transport rate follows the same relationship with phloem N transport regardless of irrigation conditions and cultivars, and seems to depend mostly on grain weight (i.e., mg per grain). Depending on the assumption made for phloem sap sucrose concentration, either phloem sap velocity or its proportionality coefficient to xylem velocity change little with environmental conditions. Taken as a whole, phloem transport from leaves to grains seems to be homeostatic within a narrow range of values and following relationships with other plant physiological parameters across cultivars and conditions. This suggests that phloem transport per se is not a limitation for yield in wheat but rather, is controlled to sustain grain filling.
A retrospective multicentric cohort study of checkpoint inhibitors‐induced pruritus with focus on management
Authors: Papageorgiou Chryssoula , Lazaridou Elizabeth , Lallas Konstantinos , Papaioannou Kyparissos , Nikolaou Vasiliki , Mateeva Valeria , Efthymiadis Konstantinos , Koukoutzeli Chrysanthi , Loga Konstantia , Sogka Eleni , Karamitrousis Evangelos , Lazaridis George , Dionysopoulos Dimitrios , Lallas Aimilios , Kemanetzi Christina , Fotiadou Christina , Timotheadou Eleni , Apalla Zoe 
Published: June 2023

AbstractBackgroundLimited data on immune checkpoint inhibitor (ICI)‐induced pruritus per se and efficacy of different therapeutic modalities in its management exist.ObjectiveTo study the quantitative and qualitative characteristics of ICI‐induced pruritus per se and to assess the efficacy of the therapeutic modalities usually applied.MethodsWe retrospectively reviewed the records of 91 patients who were under treatment with ICIs for any kind of neoplasia and developed pruritus during treatment.ResultsTwenty out of 91 individuals (22.0%) with ICI‐induced pruritus had pruritus as the only symptom, while 71/91 (78.0%) presented with pruritus coexisting with an additional cutaneous toxicity. Pruritus was treated with antihistamines (18/20, 90.0%) and/or topical regimens, as first‐line choice. In resistant cases, as a second therapeutic intervention, narrow‐band UVB (NBUVB), oral steroids and GABA analogs were added (70.0%). Statistical analysis revealed a significant difference in mean pruritus Numerical Rating Scale (NRS) scores between baseline and sequential visits. Moreover, subgroup analysis revealed a significant reduction in mean NRS scores in those treated with phototherapy.LimitationsRetrospective design, low number of patients and survivorship bias.ConclusionPruritus per se was present in a substantial portion of our cohort (22.0%). Our study confirms the efficacy of current treatment strategies and suggests NBUVB as a potential steroid‐sparing therapeutic alternative.