bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Intraocular Lens Opacification After Endothelial Keratoplasty for Different Intraocular Lens Models: A Retrospective Single-Center Cohort Study
Authors: Lorenzana-Blanco Natalia , Velarde-Rodríguez Gonzalo , Corte-Alonso Sofía , Mahillo-Fernández Ignacio , García-Sandoval Blanca , Jiménez-Alfaro Ignacio , Alejandre-Alba Nicolás 
Published: January 2023

Purpose:
The aims of this study were to calculate the specific risk of opacification for different intraocular lens (IOL) models and to determine whether differences exist, even between lenses made of similar acrylic materials.

Methods:
This is a retrospective cohort study of all patients who underwent endothelial keratoplasty (EK), either after or in conjunction with cataract surgery, from June 2009 to October 2020 at Fundación Jiménez Díaz Hospital.

Results:
Three hundred seventy-two eyes of 308 patients with a median follow-up of 856 days [interquartile range (IQR): 384–1570] were included, of which 128 IOLs were hydrophobic, 120 hydrophilic, and 124 unknown. 12.9% of IOLs opacified after a median of 466 days (IQR: 255–743). Visual acuity (VA) was significantly lower in the opacified IOL group [0.51 (IQR: 0.36–1.13)] compared with the nonopacified group [0.22 (IQR: 0.11–0.65)] (P < 0.001). IOL explantation and exchange was performed in 10 eyes, in which VA improved markedly, from 1.75 (IQR: 0.99–3.00) to 0.60 (IQR: 0.36–0.86) (P = 0.004). IOL material and opacification events were not independent (P < 0.001). Significant differences were found between the Akreos ADAPT AO and MI60P models and the Asphina 409M model (P = 0.022). No significant differences were found in the opacification ratio for hydrophilic IOLs in the clinical diagnosis (P = 0.11), the type of EK (P = 0.25), the rebubbling rate (P = 0.44), or the tamponade used (P = 0.36).

Conclusions:
Hydrophilic lenses should be avoided in patients at risk of requiring EK. It is important to know the probability of opacification of each IOL model to balance risk and benefits when planning an EK procedure because not all lenses opacify equally. Opacification is an unwanted event with a negative impact on VA, making IOL explantation and exchange the only viable treatment, although one that is not without risks.
A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype
Authors: Lemay-St-Denis Claudèle , Alejaldre Lorea , Jemouai Zakaria , Lafontaine Kiana , St-Aubin Maxime , Hitache Katia , Valikhani Donya , Weerasinghe Nuwani W. , Létourneau Myriam , Thibodeaux Christopher J. , Doucet Nicolas , Baron Christian , Copp Janine N. , Pelletier Joelle N. 
Published: January 2023

We present a potential mechanism for emergence of catalytic activity that is essential for survival, from a non-catalytic protein fold. The type B dihydrofolate reductase (DfrB) family of enzymes were first identified in pathogenic bacteria because their dihydrofolate reductase activity is sufficient to provide trimethoprim (TMP) resistance. DfrB enzymes are described as poorly evolved as a result of their unusual structural and kinetic features. No characterized protein shares sequence homology with DfrB enzymes; how they evolved to emerge in the modern resistome is unknown. In this work, we identify DfrB homologues from a database of putative and uncharacterized proteins. These proteins include an SH3-like fold homologous to the DfrB enzymes, embedded in a variety of additional structural domains. By means of functional, structural and biophysical characterization, we demonstrate that these distant homologues and their extracted SH3-like fold can display dihydrofolate reductase activity and confer TMP resistance. We provide evidence of tetrameric assembly and catalytic mechanism analogous to that of DfrB enzymes. These results contribute, to our knowledge, the first insights into a potential evolutionary path taken by this SH3-like fold to emerge in the modern resistome following introduction of TMP.
This article is part of the theme issue ‘Reactivity and mechanism in chemical and synthetic biology’.
MedKLIP: Medical Knowledge Enhanced Language-Image Pre-Training
Authors: Wu Chaoyi , Zhang Xiaoman , Zhang Ya , Wang Yanfeng , Xie Weidi 
Published: January 2023

AbstractIn this paper, we consider the problem of enhancing self-supervised visual-language pre-training (VLP) with medical-specific knowledge, by exploiting the paired image-text reports from the radiological daily practice. In particular, we make the following contributions:First, unlike existing works that directly process the raw reports, we adopt a novel report filter to extract the medical entities, avoiding unnecessary complexity from language grammar and enhancing the supervision signals;Second, we propose a novel entity embedding module by querying an external knowledge description base, to exploit the rich context of additional information that the medical domain affords, and implicitly build relationships between entities in the language embedding space;Third, we propose a novel Transformer-based fusion model for spatially aligning the entity description with visual signals at the image patch level only with self-supervised learning, thus enabling the ability for spatial grounding;Fourth, we conduct thorough experiments to validate the effectiveness of our proposed architecture, and benchmark on numerous public benchmarks e.g., ChestX-ray14, RSNA Pneumonia, SIIM-ACR Pneumothorax, COVIDx CXR-2, COVID Rural, and EdemaSeverity. In both zero-shot and fine-tuning settings, our model has demonstrated strong performance compared with the former methods on disease classification and grounding.
Let there be nightlights: the ecological role of bioluminescence in a Costa Rican mushroom
Authors: Adams Catharine A , Donald Marion , Anderson Christin , Escudero Efraín , Sourell Susanne , Landrein Sven , Seas Carolina , Mueller Greg , Chaverri Priscilla 
Published: January 2023

AbstractBoth marine and terrestrial organisms produce light enzymatically in a process called bioluminescence. Though the ecological role of light production is known for some species, such as fireflies and bacteria, the ecological role in mushroom-producing fungi remains relatively unexplored, particularly in Central America. Here, we discovered a bioluminescent mushroom in the high-elevation oak forests of Costa Rica. We developed mushroom models with Light-Emitting Diodes (LEDs) producing various colors: green, blue, red, and yellow. Over three consecutive evenings after sunset, we applied Tanglefoot invertebrate-trapping glue to both mushroom models and actual mushrooms, and collected the traps before sunrise, then identified the trapped invertebrates to Order. We found green LED traps attracted more invertebrates than non-lit control traps, suggesting that light functions to attract invertebrates. The majority of invertebrates attracted to the green lights were Dipteran flies, who would be capable of dispersing fungal spores. The higher-intensity green LEDs attracted more total invertebrates than the dimmer mushrooms, but the results were not significant. Though we predicted that the invertebrate assemblages attracted to green lights would be similar to the invertebrate assemblage attracted to actual mushrooms, the results were not significant. Similarly, the red, blue, and yellow LEDs attracted fewer invertebrates than the green LEDs, but the differences in community composition were not statistically significant. Our findings corroborate other similar studies in tropical regions that found bioluminescent mushrooms may attract invertebrates.
Improved Quantitative Parameter Estimation for Prostate T2 Relaxometry using Convolutional Neural Networks
Authors: Bolan Patrick J. , Saunders Sara L. , Kay Kendrick , Gross Mitchell , Akcakaya Mehmet , Metzger Gregory J. 
Published: January 2023

AbstractThis work seeks to evaluate multiple methods for quantitative parameter estimation from standard T2mapping acquisitions in the prostate. The T2estimation performance of methods based on neural networks (NN) was quantitatively compared to that of conventional curve fitting techniques. Large physics-based synthetic datasets simulating T2mapping acquisitions were generated for training NNs and for quantitative performance comparisons. Ten combinations of different NN architectures, training strategies, and training corpora were implemented and compared with four different curve fitting strategies. All methods were compared quantitatively using synthetic data with known ground truth, and further compared onin vivotest data, with and without noise augmentation, to evaluate feasibility and noise robustness. In the evaluation on synthetic data, a convolutional neural network (CNN), trained in a supervised fashion using synthetic data generated from naturalistic images, showed the highest overall accuracy and precision amongst all the methods. Onin vivodata, this best-performing method produced low-noise T2maps and showed the least deterioration with increasing input noise levels. This study showed that a CNN, trained with synthetic data in a supervised manner, may provide superior T2estimation performance compared to conventional curve fitting, especially in low signal-to-noise regions.
How empowerment and materialism contribute to anti-consumers’ well-being
Authors: Balderjahn Ingo , Hoffmann Stefan , Hüttel Alexandra 
Published: January 2023

Purpose
Because steadily growing consumption is not beneficial for nature and climate and is not the same as increasing well-being, an anti-consumerism movement has formed worldwide. The renouncement of dispensable consumption will, however, only establish itself as a significant lifestyle if consumers do not perceive reduced consumption as a personal sacrifice. Since prior research has not yielded a consistent understanding of the relationship between anti-consumption and personal well-being, this paper aims to examine three factors about which theory implies that they may moderate this relationship: decision-control empowerment, market-control empowerment and the value of materialism.

Design/methodology/approach
The analysis is based on data from a large-scale, representative online survey (N = 1,398). Structural equation modelling with latent interaction effects is used to test how three moderators (decision-control empowerment, market-control empowerment and materialism) affect the relationship amongst four types of anti-consumption (e.g. voluntary simplicity) and three different well-being states (e.g. subjective well-being).

Findings
While both dimensions of empowerment almost always directly promote consumer well-being, significant moderation effects are present in only a few but meaningful cases. Although the materialism value tends to reduce consumers’ well-being, it improves the well-being effect of two anti-consumption styles.

Research limitations/implications
Using only one sample from a wealthy country is a limitation of the study. Researchers should replicate the findings in different nations and cultures.

Practical implications
Consumer affairs practitioners and commercial marketing for sustainably produced, high-quality and long-lasting goods can benefit greatly from these findings.

Social implications
This paper shows that sustainable marketing campaigns can more easily motivate consumers to voluntarily reduce their consumption for the benefit of society and the environment if a high level of market-control empowerment can be communicated to them.

Originality/value
This study provides differentiated new insights into the roles of consumer empowerment, i.e. both decision-control empowerment and market-control empowerment, and the value of materialism to frame specific relationships between different anti-consumption types and various well-being states.
Hidden Differences in Phenomenal Experience
Authors: Lupyan Gary , Uchiyama Ryutaro , Thompson Bill , Casasanto Daniel 
Published: January 2023

AbstractIn addition to the many easily observable differences between people, there are also differences in people's subjective experiences that are harder to observe, and which, as a consequence, remain hidden. For example, people vary widely in how much visual imagery they experience. But those who cannot see in their mind's eye, tend to assume everyone is like them. Those who can, assume everyone else can as well. We argue that a study of such hidden phenomenal differences has much to teach cognitive science. Uncovering and describing this variation (a search for unknown unknowns) may help predict otherwise puzzling differences in human behavior. The very existence of certain differences can also act as a stress test for some cognitive theories. Finally, studying hidden phenomenal differences is the first step toward understanding what kinds of environments may mask or unmask links between phenomenal experience and observable behavior.
Vibrational signals are species‐specific and sex‐specific for sexual communication in the tea leafhopper, Empoasca onukii
Authors: Zhang Huining , Bian Lei , Cai Xiaoming , Yao Qi , Fu Nanxia , Shan Yao , Chen Zongmao 
Published: January 2023

AbstractEmpoasca onukii Matsuda (Hemiptera: Cicadellidae) is the primary pest of tea gardens, but the species' sexual communication and mating behavior is currently unclear. A similar species, Empoasca vitis Göthe, had been reported to use vibrational signals for mating communication, so we studied these two aspects from the perspective of biotremology. First, laser vibrometry detected both males and females could emit vibrational signals that are sex specific. Females emitted one signal type (the female signal), and males emitted two signal types: the male calling signal and the male courtship signal. Compared with the male signals, the female signal has a simpler structure, lower dominant frequency, and shorter length. Second, the vibrational signals of E. onukii play a decisive role in sexual communication. The male emits calling signals and then recognizes the female based on her reply signal; after establishing a duet with the female, the male emits a series of courtship signals, and then continually locates and approaches the female according to her reply signals, and finally attempts to copulate. Third, vibrational signals of E. onukii are species‐specific. Comparing E. onukii and E. vitis, there are differences in three aspects: the emitting behavior of female signals, the types of male signals, and the structure of male and female signals. We conclude that E. onukii uses sex‐ and species‐specific vibrational signals for sexual communication.
Buccal bone thickness and mid‐facial soft tissue recession after various surgical approaches for immediate implant placement: A systematic review and network meta‐analysis of controlled trials
Authors: Wu Xin‐Yu , Shi Jun‐Yu , Buti Jacopo , Lai Hong‐Chang , Tonetti Maurizio S. 
Published: January 2023

AbstractAimTo evaluate the relative efficacy and confidence in the precision of the results of different surgical interventions for immediate implant placement in the anterior area.Materials and MethodsElectronic searches were performed in PubMed, Embase, and Cochrane CENTRAL. Randomized controlled trials comparing different surgical techniques in anterior jaws for type 1 implant placement were included. Outcome measures included implant survival (primary outcome), buccal bone thickness (BBT) reduction, and mid‐facial soft tissue recession (MSTR). Risks of bias assessment, network meta‐analysis (NMA), sensitivity analysis, and quality‐of‐evidence assessment were performed.ResultsTwenty‐two studies reporting on 948 subjects and 5 surgical interventions were included. Fourteen early failures were reported. Compared with open‐flap surgery without tissue augmentation (F‐N) and looking at BBT preservation, NMA showed that there was moderate confidence that flapless surgery with hard tissue augmentation (FL‐HTA) was better than flapless surgery without tissue augmentation (FL‐N) or open‐flap surgery with hard tissue augmentation (F‐HTA) (mean difference –0.8 mm, 95% confidence interval: −1.1 to −0.5 mm; −0.6 mm, −0.9 to −0.4 mm; and −0.5 mm, −0.7 to −0.3 mm, respectively). There was moderate confidence that flapless surgery with hard and soft tissue augmentation (FL‐HTA&STA) could significantly prevent MSTR compared with FL‐HTA (−0.5 mm, −0.7 to −0.3 mm) and FL‐N (−0.6 mm, −1.2 to −0.04 mm). However, there was no significant additional benefit in BBT with the FL‐HTA&STA approach compared to the FL‐HTA approach (−0.30 mm, −0.81 to 0.21 mm).ConclusionsFor immediate implant placement in the anterior areas, the FL‐HTA approach better preserves BBT (moderate confidence); adding STA improves the stability of the mid‐facial soft tissue level (moderate confidence) but at the expense of BBT (low confidence).
Molecular mechanisms in chloroquine‐exposed muscle cells elucidated by combined proteomic and microscopic studies
Authors: Phan Vietxuan , Hathazi Denisa , Preuße Corinna , Czech Artur , Freier Erik , Shema Gerta , Zahedi René P. , Roos Andreas 
Published: January 2023

AbstractObjectivesChloroquine (CQ) is an antimalarial drug with a growing number of applications as recently demonstrated in attempts to treat Covid‐19. For decades, it has been well known that skeletal and cardiac muscle cells might display vulnerability against CQ exposure resulting in the clinical manifestation of a CQ‐induced myopathy. In line with the known effect of CQ on inhibition of the lysosomal function and thus cellular protein clearance, the build‐up of autophagic vacuoles along with protein aggregates is a histological hallmark of the disease. Given that protein targets of the perturbed proteostasis are still not fully discovered, we applied different proteomic and immunological‐based studies to improve the current understanding of the biochemical nature of CQ‐myopathy.MethodsTo gain a comprehensive understanding of the molecular pathogenesis of this acquired myopathy and to define proteins targets as well as pathophysiological processes beyond impaired proteolysis, utilising CQ‐treated C2C12 cells and muscle biopsies derived from CQ‐myopathy patients, we performed different proteomic approaches and Coherent Anti‐Stokes Raman Scattering (CARS) microscopy, in addition to immunohistochemical studies.ResultsOur combined studies confirmed an impact of CQ‐exposure on proper protein processing/folding and clearance, highlighted changes in the interactome of p62, a known aggregation marker and hereby identified the Rett syndrome protein MeCP2 as being affected. Moreover, our approach revealed—among others—a vulnerability of the extracellular matrix, cytoskeleton and lipid homeostasis.ConclusionWe demonstrated that CQ exposure (secondarily) impacts biological processes beyond lysosomal function and linked a variety of proteins with known roles in the manifestation of other neuromuscular diseases.
Youth engagement in research and policy: The CO‐CREATE framework to optimize power balance and mitigate risks of conflicts of interest
Authors: Nesrallah Samantha , Klepp Knut‐Inge , Budin‐Ljøsne Isabelle , Luszczynska Aleksandra , Brinsden Hannah , Rutter Harry , Bergstrøm Elin , Singh Sudhvir , Debelian Marianna , Bouillon Claire , Katanasho Margrete Bjørge 
Published: January 2023

SummaryIncluding youth in the co‐creation of policies that affect them has proven to be particularly impactful in public health. Using youth participatory action research methods, the CO‐CREATE project engages European youth 16–18 years old in the co‐creation of obesity prevention policies. To discuss the feasibility and implications of the policy, youth are invited to engage in an intergenerational dialogue. Given the youth–adult dynamic and policy discussion, conflicts of interests (COIs) can arise and impact the quality of the dialogue. COI frameworks are a tool that can help identify, mitigate, and address COIs. This paper presents a novel framework to mitigate COIs in intergenerational policy dialogues, with a focus on power imbalance. Following a series of youth consultations, interviews, and examination of existing frameworks, our findings suggest that safe, participatory, and empowering dialogues can take place if appropriate measures are integrated into all phases of a dialogue. The selection of stakeholders, use of accessible language, and youth moderation are all factors that can impact COI risks. Measures that promote mutual empowerment, such as equal representation of youth and adults, were deemed important. This framework provides a roadmap to ensure that youth participation in the formulation of policies is safe and empowering.
Neighbourhood walkability is associated with risk of gestational diabetes: A cross‐sectional study in New York City
Authors: Rundle Andrew G. , Kinsey Eliza W. , Widen Elizabeth M. , Quinn James W. , Huynh Mary , Lovasi Gina S. , Neckerman Kathryn M. , Van Wye Gretchen 
Published: January 2023

AbstractBackgroundDespite the links between neighbourhood walkability and physical activity, body size and risk of diabetes, there are few studies of neighbourhood walkability and risk of gestational diabetes (GD).ObjectivesAssess whether higher neighbourhood walkability is associated with lower risk of GD in New York City (NYC).MethodsCross‐sectional analyses of a neighbourhood walkability index (NWI) score and density of walkable destinations (DWD) and risk of GD in 109,863 births recorded in NYC in 2015. NWI and DWD were measured for the land area of 1 km radius circles around the geographic centroid of each Census block of residence. Mixed generalised linear models, with robust standard error estimation and random intercepts for NYC Community Districts, were used to estimate risk ratios for GD for increasing quartiles of each of the neighbourhood walkability measures after adjustment for the pregnant individual's age, race and ethnicity, parity, education, nativity, and marital status and the neighbourhood poverty rate.ResultsOverall, 7.5% of pregnant individuals experienced GD. Risk of GD decreased across increasing quartiles of NWI, with an adjusted risk ratio of 0.81 (95% Confidence Interval (CI) 0.75, 0.87) comparing those living in areas in the 4th quartile of NWI to those in the first quartile. Similarly, for comparisons of the 4th to 1st quartile of DWD, the adjusted risk ratio for GD was 0.77 (95% CI 0.71, 0.84).ConclusionsThese analyses find support for the hypothesis that higher neighbourhood walkability is associated with a lower risk of GD. The analyses provide further health related support for urban design policies to increase walkability.