bluuebunny/crossref_metadata_2025_split huggingface dataset:
PSTK exerts protective role in cisplatin‐tubular cell injury via BAX/BCL2/Caspase3 pathway
Authors: Wu Yifan , Xv Yuanyuan , Zhao Limei , Zhou Ziqi , Wang Miaomiao , Xi Jima , Liming Ying , Gao Jianling , Deng Bingqing , Zheng Dong 
Published: January 2025

AbstractCisplatin is a widely used anticancer drug, but its accumulation in renal tubular epithelial cells (TECs) can cause acute kidney injury. Phosphoseryl‐tRNA kinase (PSTK) is an intermediate product produced under oxidative stress conditions. This study aimed to elucidate whether PSTK could protect TECs and its possible mechanisms. We found that PSTK levels decreased after cisplatin treatment, but PSTK overexpression using lentivirus vectors protected TEC viability. Overexpression of PSTK increased selenoprotein concentrations and reduced intracellular ROS levels. Additionally, PSTK overexpression inhibited the BAX/BCL2/Caspase 3 pathway after cisplatin stimulation, suggesting its potential role in preventing cell apoptosis. Taken together, this study suggests that PSTK could protect TEC viability from cisplatin‐induced injury, possibly by inhibiting mitochondrial apoptosis. The study is significant for developing therapeutic strategies that could manipulate PSTK to delay AKI progression.
(H)ariuga/(h)aruiga: an etymological research
Authors: Sarullo Giulia 
Published: January 2025

Abstract
The term (h)ariuga/(h)aruiga is exclusively attested as a gloss for a sacrificial animal in Latin grammarians. However, inconsistencies in the textual transmission of the term – with fluctuations in the presence or absence of the initial h- and a different sequence of the (semi-)vocalic elements of the central syllable – necessitate a critical examination of the manuscript tradition of primary sources like Varro and Festus. A subsequent morphological analysis aims to determine the word’s structure. This study reviews previous etymological proposals, ultimately rejecting those deemed untenable and ranking the remaining possibilities. By comparing Latin and Greek data, we dismiss the notion of a simple term, prevalent until the 19th century. While most contemporary scholars favor a compound structure, their reconstructions often face semantic challenges. Our research re-examines the hypothesis of a derivative with the prefix ad- and introduces novel explanations to enhance the semantic plausibility of the term.
The synchrony and diachrony of example markers in Latin
Authors: Magni Elisabetta , Cepraga Ottavia 
Published: January 2025

Abstract
This article aims to fill a gap in the current literature on the pragmatics of Latin by proposing a corpus-based analysis of the different words (e.g., ut, uelut, sicut), phrases (e.g., exempli gratia, uerbi causa), and constructions (e.g., ut puta, si dicas) exploited to signal the process of exemplification. The structures and devices that perform this discursive operation are essentially neglected in Latin handbooks of syntax and stylistics, and only sparse comments on individual forms can be found in the lexica and in recent literature. To investigate these understudied issues, we have devised a functional taxonomy centred around the notions of meta-exemplification, canonical exemplification, and para-exemplification. The analysis of the data illustrating the different strategies and signals of exemplification is based on the tenets of historical pragmatics. The discussion focuses on the multiple roles and emergence of example markers in different textual genres, with special attention to technical prose and grammatical treatises, where examples are crucial in describing natural categories and explaining linguistic phenomena. The significance of the results extends beyond the Latin language and sheds light on the origin and development of example markers in general.
Dormivit et resurgit. A language-ecology approach to the diachrony of the Latin ingressive perfect
Authors: Aerts Simon 
Published: January 2025

Abstract
After the merger of the perfect and aorist stems, the resulting perfectum stem in Latin kept its less central functions such as resultativity and ingressivity as marked aspectual meanings in its semantic potential. Occurring first in literary and especially poetic text, as a dormant, archaic function, its use was revived in the 4th century due to intensifying exchanges with New Testament Greek, where the ingressive aorist was still more productive. The current paper examines, on the basis of a representative sample selected from all relevant time periods and various text types, perfectum stem forms of a substantial number of stative verbs in a close-reading process, in order to ascertain more accurately the dynamics of the diachrony of Latin ingressivity. The occurrence rate of this form-function pairing is compared to significant alternations of a number of contextual factors, such as discourse type, mood, predicate fronting and the dynamics in the system of lexical ingressivity.
Ecce in Archaic Latin: interjection or demonstrative?
Authors: Orqueda Verónica , Rivera Castro Renata , Toro Varela Francisca 
Published: January 2025

Abstract
Longstanding debate persists regarding the classification of Latin ecce as word class. While some scholars regard it as a particle or demonstrative, others characterize it as an interjection. This study examines the implications of these approaches and analyzes the behavior of ecce in Archaic Latin according to different grammatical and semantic criteria. The analysis confirms that ecce functions primarily as a predicative demonstrative. Furthermore, it contends that ecce can be specifically categorized as a presentative predicative demonstrative. These results suggest that the interjectional use of this demonstrative must have arisen only secondarily.
Cell indices as predictors of progression-free survival in multiple myeloma: a retrospective cohort study
Authors: Han Viet Trung , Vu Minh Phuong , Pham Phuong Thao , Vu Hoang , Duong Hai Yen 
Published: January 2025

Abstract

Objectives
Certain basic cell indices may possess prognostic significance in the treatment of multiple myeloma (MM). This study aims to evaluate the prognostic value of a combination of cell indices (CCI), comprising the percentage of bone marrow plasma cells (BMPCs), neutrophil-to-lymphocyte ratio (NLR), and platelet count, on progression-free survival (PFS) in MM patients.

Methods
This retrospective cohort study analyzed 111 patients with newly diagnosed MM. Patients were assigned 1 point for each of the following: high percentage of BMPCs (40 %), high NLR (2.065), and low platelet count (<150 × 109/L). Based on these scores, the CCI was formulated. Patients were categorized into low-risk (0 points), intermediate-risk (1–2 points), and high-risk (3 points) groups.

Results
Univariate and multivariate analyses identified CCI as an independent prognostic factor for PFS (intermediate-risk group: Hazard ratio (HR) 3.538, 95 % CI: 1.592–7.860, high-risk group; HR 5.049, 95 % CI: 1.890–13.482, p<0.001). The PFS for the low-risk, intermediate-risk, and high-risk groups were 41.732, 27.758, and 16.600 months, respectively.

Conclusions
The CCI, incorporating the percentage of BMPCs, NLR, and platelet count, may serve as an independent prognostic factor for PFS in MM patients.
Species Composition, Genetic Structure, and Pathogen Prevalence in Tick Populations in Guangxi, China
Authors: Jiang Na , Tian Haoqiang , Li Chunfu , Ma Rui , Liu Mengyun , Wang Shurong , Zhou Qingan , Wei Xiankai , Mo Juanmei , Chen Zimei , Sheng Zhaoan , Duan Lei , He Lu , Song Peng , Sun Jiahui , Li Jian , Hu Wei , Feng Xinyu 
Published: January 2025

Background:
Ticks are important vectors for many pathogens affecting humans and animals. This study was aimed at investigating the species composition, genetic diversity, and potential transmission risks of tick-borne pathogens in the Guangxi Zhuang Autonomous Region, China.

Methods:
A total of 980 ticks were collected from 14 prefecture-level cities in Guangxi between March and July 2021. Ticks were identified morphologically and genetically, and the population diversity of Rhipicephalus microplus was analyzed according to 16S rDNA, COXI, and ITS-2 gene sequences. Population genetics was assessed through FST, AMOVA, and phylogenetic analyses. PCR was used to detect five common tick-borne pathogens: Rickettsia, Babesia, Theileria, Borrelia burgdorferi, and Anaplasma phagocytophilum.

Results:

Rhipicephalus microplus was the dominant tick species, and was observed in 92.04% of all samples. Genetic diversity analysis revealed higher haplotype diversity for the 16S rDNA and COXI genes than the ITS-2 gene; these findings suggested a faster evolutionary rate for the first two markers. Population genetic differentiation was observed between Rhipicephalus microplus populations in Guilin, Hechi, and other regions, probably because of geographic isolation. Pathogen analysis revealed a 13.27% overall infection rate, and identified three Rickettsia, two Babesia, and three Theileria species. Co-infection with Theileria and Rickettsia was also detected. Notably, neither Borrelia nor Anaplasma was found in the tick samples. Phylogenetic analyses confirmed the distinctiveness of the Rickettsia and Piroplasma groups.

Conclusions:
This study provides a comprehensive assessment of tick species diversity and tick-borne pathogens in Guangxi, highlighting the potential health risks posed by Rhipicephalus microplus. The findings emphasize the need for expanded tick surveillance, enhanced pathogen detection methods, and integrated management strategies to mitigate the spread of tick-borne diseases. Future research should include the collection of free questing ticks and metagenomic approaches to provide a more comprehensive understanding of pathogen risk in the region.
The Course of Dyskeratosis Congenita Masked by Crohn’s Disease in a Primary School-Age Child: Case Report
Authors: Bessonov Evgeniy E. , Surkov Andrey N. , Arakelyan Anna L. , Getmanov Stanislav D. , Zhurkova Natalia V. , Namazova-Baranova Leyla S. 
Published: January 2025

Background. Dyskeratosis congenita (DC) is an extremely rare genetically determined syndrome associated with the formation of bone marrow depression and clinically manifested by abnormal pigmentation of the skin, onychodystrophy, cobble-stone tongue, damage to the gastrointestinal tract, lungs, etc. Pathology may occur under the guise of other, more common diseases, which leads to late verification of the diagnosis and affects the prognosis. Case report. The boy D., aged 7 years, was hospitalized with complaints of dysphagia, a change in the shape of nails, ulcerative lesions of the tongue, insufficient weight gain, thin stool. Laboratory: decrease in hemoglobin, pancytopenia, low concentration of IgG in blood serum. According to esophagogastroduodenoscopy— esophageal stenosis. Crohn’s disease was suspected, but the condition worsened against the background of anti-TNF therapy. According to the results of full-exome sequencing, a pathogenic variant c.1058C>T (chrX:154001427C>T; NM_001363.3; p.A353V) was detected in the DKC1 gene in a hemizygous state, on the basis of which DC was confirmed. Conclusion. Practitioners should be wary of DC, since its manifestations can often mimic other, more common pathological conditions, in particular inflammatory bowel diseases. The correct interpretation of the combination of clinical, laboratory and instrumental changes can help to get closer to the correct diagnosis even before receiving the results of a molecular genetic study and determine therapeutic tactics.
The Effectiveness of Using the HandTutor Hand Simulator and Stabilometric Postural Control Using the Biofeedback Tear in Preschool and Primary School Children with Cerebral Palsy
Authors: Ashrafova Ulviya Sh. , Mamedyarov Ayaz M. , Karmazina Elena K. , Klochkova Olga A. , Kuprianova Olga S. 
Published: January 2025

Background. Currently, mechanotherapy is widely used in the rehabilitation of mainly adult patients and adolescents. The possibilities of using this technique in children of early, preschool and primary school age are limited due to the minimal presence of specialized devices. The aim of the study is the assessment of the effectiveness of a comprehensive rehabilitation program with the inclusion of a HandTutor hand simulator and stabilometrical postural control using the biofeedback method in preschool and primary school age children suffering from infantile cerebral palsy (ICP). Materials and methods. 40 children aged 3 to 7 years with motor disorders with a diagnosis of ICP were under observation. The effectiveness of the program was evaluated using scales and hardware measurement data (HandTutor, “Amblyotron”). Results. According to goniometric changes and data on the Ashworth scale, after rehabilitation, patients demonstrate a greater range of movements than before treatment (p < 0.05). The indicators of the area of the pressure center and its fluctuations have significantly improved in the form of improved stability (p £ 0.01), the pattern of vertical posture, walking and postural control in general. Conclusion. After treatment, patients showed a marked decrease in the degree of muscle spasticity of the affected limb, an increase in muscle strength, an improvement in fine and large hand motor skills, and manual skills. Thus, the results of the study demonstrate the high effectiveness of biomechanical methods of influence, namely HandTutor and “Amblyotron”, on the motor sphere of patients with severe motor disorders.
HETEROPHILE ANTIBODIES – A RARE BUT SIGNIFICANT CAUSE OF FALSE POSITIVE CARDIAC TROPONIN LEVELS
Authors: Chaulin Alexey M. , Duplyakova Polina D. , Duplyakov Dmitry V. 
Published: January 2025

HighlightsPractitioners regularly encounter unexplained (false-positive) causes and mechanisms of increased concentrations of cardiac troponins. One of the most significant and common causes of false increases in cardiac troponin levels are heterophile antibodies. There are no articles in domestic and foreign databases that systematize in detail information about the prevalence, mechanisms of increase and ways to combat this cause of false-positive increase in cardiac troponin concentration, which was the purpose of this manuscript. AnnotationAccording to traditional concepts, cardiospecific troponins (cTnT and cTnI) are the most important laboratory biomarkers with high diagnostic value in myocardial infarction (MI). The development of new generations of methods for determining cTnT and cTnI, also called high- and ultra-sensitive methods, has expanded the diagnostic capabilities of cardiac troponins in relation to other diseases in which myocardial tissue is involved in the pathological process, thereby carrying additional prognostic value. Given the wide scope for use of cTnT and cTnI, which is not limited to the diagnosis of MI, there is an urgent need to carefully identify all factors that can in any significant way affect or distort the result of laboratory testing of blood serum for cTnT and cTnI. Among all known factors affecting the concentration of cTnT and cTnI, heterophile antibodies are the most significant in terms of the degree of change (increase) in serum levels. In this review, we will consider the main causes of the formation of heterophile antibodies, the mechanisms of their influence on the concentration of cTnT and cTnI, as well as methods for detecting and combating heterophile antibodies.
DRESSLER SYNDROME IN VIEW OF MODERN IDEAS
Authors: Gamayunov Danil Yu. , Kalyagin Alexey N. , Fedotova Valentina N. 
Published: January 2025

HighlightsThe frequency of Dressler syndrome decreased sharply from 20 to less than 5% with the introduction of early reperfusion into clinical practice. Relapses of Dressler’s post-infarction syndrome are quite common. The review presents current literature data on the etiology and pathogenesis, diagnostic methods and various approaches to the treatment of Dressler syndrome, including the effectiveness of colchicine and reports on the use of immunoglobulins. AnnotationThe development of Dressler syndrome relapses within 1 year after the first occurrence of the event, despite the decrease in the frequency of the disease, emphasizes the relevance of the problem under consideration. Dressler syndrome is based on autoimmune genesis. Echocardiography is the “gold standard” of instrumental diagnostics and the most sensitive imaging method for suspected Dressler syndrome, but in some cases magnetic resonance imaging may be effective. There is currently no single treatment regimen for autoimmune pericarditis. Most literature sources indicate the most frequent use of nonsteroidal anti-inflammatory drugs, glucocorticosteroids and colchicine. The article highlights the literature data on etiology, modern views on pathogenesis, current methods of diagnosis of Dressler syndrome and various approaches to treatment tactics and drug selection. The following resources were used: eLIBRARY.ru, PubMed. The keywords were as follows: “Dressler syndrome”, “postinfarction syndrome”, “postpericardiotomy syndrome”, “myocardial infarction”. The articles published primarily in the last 5 years (2017-2022) were preferred.
CURRENT ISSUES OF MODELING HEART FAILURE AND MYOCARDIAL FIBROSIS IN RATS
Authors: Smirnova Elena A. , Ponomareva Olga V. 
Published: January 2025

HighlightsMethods for modeling heart failure in rats are classified into models requiring surgical intervention, toxic, genetic and autoimmune models, models based on the effects of physical factors, the use of special dietary regimens.It is impossible to single out a single ideal model, since the development of heart failure is a multifactorial process, it is preferable to use a combination of several methods.The correctness of the choice of the model and its compliance with the tasks of future research must be confirmed by combining several diagnostic methods for verifying myocardial fibrosis - laboratory, histological, instrumental. AnnotationDetailed study of the mechanisms of heart failure and its main pathogenetic factor, myocardial fibrosis, is required for developing new effective treatment strategies. The choice of an appropriate model is key for a reliable experimental study. The aim of the review is to systematize current data on methods for modeling heart failure in rats. The main advantages of these animals are high genetic, biochemical and physiological similarity with humans, ease of breeding, availability of maintenance, small size, while allowing for surgery. This article classifies the currently available rat models of heart failure, discusses their pathophysiological basis, timing of the formation of heart failure, clinical features, advantages and disadvantages of each experimental model. The authors have paid particular attention to methods developed by domestic scientists. Methods for assessing the developed myocardial fibrosis and the influence of drugs on its formation are considered. The study of heart failure requires reliable animal models to assess biochemical, functional, morphological changes in damaged myocardium, and controlled testing of new drugs. Should the necessity arise, specialists should use several methods simultaneously, whereas the choice of treatment strategy depends on the aim of the study.
ACUTE MYOCARDIAL INJURY AFTER SURGICAL LUNG RESECTION: INCIDENCE, CLINICAL FEATURES, PREDICTORS
Authors: Protasov Konstantin V. , Barakhtenko Olga A. , Batunova Elena V. 
Published: January 2025

HighlightsAcute perioperative myocardial injury develops in 38.5% of patients with non – small cell lung cancer and is associated with the ThRCRI major cardiac events risk index, preoperative hemoglobin level and postoperative heart rate. Aim. To determine the incidence and predictors of acute myocardial injury after surgical treatment of patients with non – small cell lung cancer (NSCLC).Methods. The study included 104 men aged 63.0 [58–67] years who underwent lung resection for NSCLC. Blood levels of cardiac troponin I (cTnI) were determined before and 24 and 48 hours after surgery. Myocardial injury after noncardiac surgery (MINS) was diagnosed when postoperative cTnI increased > 99th percentile of the upper reference limit. Two patients with elevated cTnI of non-ischemic origin were excluded from the analysis. In groups with and without MINS, clinical parameters were compared and their relationships with the MINS development were assessed using univariate regression. Multivariate logistic regression analysis was performed to identify independent MINS predictors. ROC curves were constructed and threshold values of quantitative variables associated with the study outcome were determined.Results. MINS was diagnosed in 40 patients (38.5%). In 36 of them, the cTnI increase was asymptomatic. Among patients with MINS, in contrast to the group without MINS, the share of pneumonectomy, heart rate (HR) after surgery and the cardiac events risk index ThRCRI were higher, as well as hemoglobin level before surgery was lower. Using multiple logistic regression, a combination of factors that provides the greatest accuracy in predicting MINS was identified: ThRCRI index ≥ 1 (adjusted odds ratio (OR) 5.85, 95% confidence interval [1.41–24.28]), hemoglobin before surgery (OR 0.68 [0.5–0.91] for every 10 g/L), HR after surgery (OR 1.99 [1.26–3.13] for every 10 min–1). Threshold levels were established for hemoglobin before surgery (135 g/L), below which the OR for MINS was 2.54 [1.12–5.75], and postoperative HR (88 min–1), above which the OR for MINS was 2.64 [1.16–5.99].Conclusion. The incidence of acute myocardial injury after NSCLC surgery is 38.5%. In 90% of cases the MINS was asymptomatic. A mathematical model was created and following independent predictors of MINS were established: ThRCRI index ≥ 1, hemoglobin level before and heart rate after the surgery. At a threshold hemoglobin value < 135 g/L and HR>88 min–1, the risk of MINS increases significantly.
AUTOMATED OPPORTUNISTIC CT-SCREENING OF ABDOMINAL AORTIC ANEURYSMS USING ARTIFICIAL INTELLIGENCE: PROSPECTS AND CHALLENGES (LITERATURE REVIEW)
Authors: Kodenko Maria R. , Vladzimirskyy Anton V. , Omelyanskaya Olga V. , Suchilova Maria M. , Blokhin Ivan A. , Gatin Denis V. , Reshetnikov Roman V. 
Published: January 2025

Highlights Non-contrast computed tomography (CT) scan is a promising modality for opportunistic screening of abdominal aortic aneurysm (AAA).Automation of opportunistic screening of AAA according to CT data is a promising use of artificial intelligence (AI) technologies.The development of AI algorithms for opportunistic screening of AAA based on CT data is currently limited due to the high labor costs in preparing datasets for AI training and testing. AnnotationAbdominal aortic aneurysm is a cardiovascular disease characterized by a latent progression and adverse prognosis. Timely diagnosis reduces surgical risks and postoperative complications. Diagnostic imaging methods used to detect and evaluate this disease, particularly in targeted and opportunistic screening, are reviewed. The prospects of automation using artificial intelligence technologies for opportunistic screening are explored, moreover, they have already proven to be effective tools for optimizing radiology reports in several fields. This review highlights, however, relatively poor development of artificial intelligence algorithms for opportunistic screening of abdominal aortic aneurysms on native non-contrast abdominal CT studies. Possible reasons for this phenomenon and potential ways of development of this subject area are investigated.