bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of shunt failure in 38,095 adult shunt insertion surgeries: a systematic review and meta-analysis
Authors: Isaacs Albert M. , Yang Runze , Cadieux Magalie , Ben-Israel David , Sader Nicholas , Opoku-Darko Michael , Frizon Leonardo , Yong Heather , Premji Zahra , Nagel Sean , Hamilton Mark G. , _ _ , _ _ , Dasher Nick , Edwards Richard , Golomb James , Holubkov Richard , Luciano Mark , Katzen Heather , McKhann Guy , Moghekar Abhay , Williams Michael A. , Wisoff Jeffrey , Zwimpfer Tom 
Published: April 2023

OBJECTIVE
The management of excess CSF in patients with hydrocephalus typically requires using a shunt to divert CSF. Unfortunately, there is a high rate of shunt failure despite improvements in device components and insertion techniques. Reoperation is frequently necessary, which contributes to patient harm and increased healthcare costs. While factors affecting shunt failure are well defined in the pediatric population, information regarding adults is lacking. The authors undertook a systematic review and meta-analysis to determine how shunt failure in the adult population is reported and investigated the etiologies of shunt failure.

METHODS
This review is reported according to PRIMSA and utilized the MEDLINE, Embase, and Google Scholar databases. Abstracts were screened by two independent reviewers, and data were extracted in duplicate by two independent reviewers. Statistical analyses were performed using SPSS and Stata.

RESULTS
The pooled rates of shunt failure were 10% (95% CI 5%–15%) in studies with a mean follow-up time of less than 1 year, 12% (95% CI 8%–14%) with a follow-up time between 1 and 2 years, and 32% in studies with a follow-up time of 2 years or greater (95% CI 19%–43%). The pooled rate of failure was 17% across all studies. The most common cause of shunt failure was obstruction at 3.0% (95% CI 2%–4%), accounting for 23.2% of shunt failures. Infection was the second most common at 2.8% (95% CI 2%–3%), accounting for 22.5% of shunt failures. The most common location of shunt failure was the distal catheter, with a failure rate of 4.0% (95% CI 3%–5%), accounting for 33.4% of shunt failures. The definition of shunt failure was heterogeneous and varied depending on institutional practices. The combination of symptoms with either CT or MRI was the most frequently reported method for assessing shunt failure.

CONCLUSIONS
Important variation regarding how to define, investigate, and report shunt failure was identified. The overall shunt failure rate in adults is at least 32% after 2 years, which, while lower than that typically reported in the pediatric population, is significant. The most common causes of shunt failure in adults are infection and obstruction. The most common site of failure occurred at the distal catheter, highlighting the need to develop strategies to both report and mitigate distal shunt failure in adult shunt patients.
HummingFlow: novel single twist-drill access for ventricular drainage, irrigation, monitoring, and automated local drug delivery in subarachnoid hemorrhage
Authors: Carrera Diego A. , Marsh Laura M. , Roach Jessica J. , Sarangarm Preeyaporn , Cole Chad D. , Torbey Michel T. , Carlson Andrew P. 
Published: April 2023

OBJECTIVE
The management of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage (aSAH) remains one of the most important targets for neurocritical care. Advances in monitoring technology have facilitated a more thorough understanding of the pathophysiology and therapeutic approaches, but interventions are generally limited to either systemic therapies or passive CSF drainage. The authors present a novel approach that combines a multimodal monitoring bolt-based system with an irrigating ventricular drain capable of delivering intrathecal medications and describe their early experience in patients with aSAH.

METHODS
The authors performed a retrospective review of cases treated with the combined Hummingbird multimodal bolt system and the IRRAflow irrigating ventriculostomy.

RESULTS
Nine patients were treated with the combined multimodal bolt system with irrigating ventriculostomy approach. The median number of days to clearance of the third and fourth ventricles was 3 days in patients with obstructive intraventricular hemorrhage. Two patients received intrathecal alteplase for intraventricular hemorrhage clearance, and 2 patients received intrathecal nicardipine as rescue therapy for severe symptomatic angiographic vasospasm.

CONCLUSIONS
Combined CSF drainage, irrigation, multimodality monitoring, and automated local drug delivery are feasible using a single twist-drill hole device. Further investigation of irrigation settings and treatment approaches in high-risk cases is warranted.
Аналіз роботи мережевих утиліт в командному вікні Windows
Authors: Miskevich О.І. 
Published: April 2023

У даній статті розглянуто основні мережеві утиліти, як запорука надійної та безпечної роботи. Для якості кожної мережі – як зовнішньої , так і локальної необхідний моніторинг та діагностика програмного та апаратного забезпечення. Поставлена задача вимагає вивчення поточних показників та збір даних. Адже є багато загроз попадання у вірусне середовище та крадіжки даних. І тому у разі виявлення різноманітних несправностей необхідно приймати відповідні та правильні рішення. Розглянуто основні мережеві утиліти: ping, ipconfig, tracert, pathping для перевірки роботи мережі через консоль Windows. Досліджено маршрути, розташування проміжних вузлів, довжину шляху та пройдені пакетами точки обміну трафіку до комп'ютерів, розташованих в різних кінцях світу.
GUARANTEES OF HUMAN RIGHTS AS AN ELEMENT OF THE RUSSIAN CONSTITUTIONAL IDENTITY
Authors: Амануллина А.Ф. 
Published: April 2023

Введение: в статье анализируется понятие конституционной идентичности, рассматривается гене- зис становления конституционных гарантий. Материалы и методы: при написании статьи проанализированы действующее российское законо- дательство, судебная практика, научные статьи и исследования; использованы общенаучные и специ- альные методы: диалектический, дедукции, индукции, формально-юридический. Результаты исследования: в настоящее время в науке возникла необходимость понимания кон- ституционной идентичности России, разработка доктрины которой до сих пор продолжается учены- ми-правоведами. Как явление многомерное и многокомпонентное, идентичность определяется через различные аспекты, в том числе и гарантии прав и свобод человека. Обсуждение и заключение: в работе обосновывается вывод, согласно которому гарантии прав и свобод человека имеют давнюю историческую традицию, сложились в результате многовекового предшествующего государственного развития, исторических и культурных традиций, поэтому явля- ются элементом российской конституционной идентичности.
Introduction: the author analyses the concept of constitutional identity, considers historical development of constitutional guarantees. Materials and Methods: the author analyzes current Russian legislation, court practice, scientific articles and studies. In the course of the study, the author used dialectical, logical deduction, induction, and technical methods. Results: for the past decade the comprehension of constitutional identification of Russia was needed which doctrine development is ongoing. As a multidimensional and complex phenomenon, the identity is defined through various aspects including the guarantees of human rights and freedoms. Discussion and Conclusion: the paper substantiates the conclusion that legal guarantees of human rights and freedoms have a long historical tradition, have developed as a result of centuries of previous state development, historical and cultural traditions, therefore they are an element of Russian constitutional identity
Bruxelles à l’heure du Donut
Authors: Thiry Géraldine , Dissaux Tristan , Dethier Fanny , Roman Philippe 
Published: April 2023

Entre plafond écologique et plancher social, Bruxelles repense son économie en s’appuyant sur la théorie du Donut. Comment la capitale européenne se saisit-elle de cet outil ? Retour d’expérience.
Origines et originalités de Masques
Authors: Sanzio Alain 
Published: April 2023

La revue trimestrielle Masques Revue des homosexualités est née en mai 1979. Dirigée par Jean-Pierre Joecker, elle a connu 24 numéros, dont deux doubles (le n o 9/10 - été 1981 et le n o 25 - été 1985), jusqu’en 1985, passant de 144 pages au n o 1 à 192 au n o 25. Il s’y ajoute trois albums Masques consacrés à Cocteau (1983), Colette (1984) et Tennessee Williams (1986) qui ne fut pratiquement pas diffusé. La revue tirait à 3 000 exemplaires, le n o 1 fut retiré à 1 000 exemplaires. Masques devint mensuel en décembre 1985 : 6 numéros parurent jusqu’en mai 86. Masques donna aussi naissance aux Éditions Persona : une SARL fut créée le 11 avril 1980 par trois des fondateurs de la revue, J.-M. Combettes, J.-P. Joecker et Alain Sanzio. Elle fut dissoute le 15 juin 1986.
Revisit on the Use of Bleach Baths as a Standardized Treatment for Atopic Dermatitis
Authors: Chan Jeffrey YM 
Published: April 2023

Background:
Atopic dermatitis is known to be associated with the colonization of Staphylococcus aureus and topical antiseptics, such as bleach bath, have been hypothesized to be effective in the treatment of atopic dermatitis.

Method:
This essay aimed to summarize the current literature on the effectiveness of bleach bath as a standard treatment for patients with atopic dermatitis. The essay also explored the relationship between S. aureus colonization and atopic dermatitis with the latest literature to understand the effects of S. aureus colonization.

Results:
The current literature seemed to suggest whereas bathing was useful in improving the severity of atopic dermatitis, bleach bath did not offer superior results when compared to water bath.

Conclusions:
Although bleach bath may not be more effective than water bath, bleach bath could still be offered to patients at the discretion of the attending clinician because bleach bath is relatively inexpensive and adverse events are rare.
Implementasi Model ATIK untuk Meningkatkan Keterampilan Proses Sains di TK Islam Baitushshobirin Kecamatan Tanjung Priok
Authors: Solikhah Solikhah , Ismiati Ismiati , Maulida Ida , Watini Sri 
Published: April 2023

Usia Emas disebut juga sebagai masa kanak-kanak awal. Istilah Anak Usia Dini juga dapat di gunakan untuk merujuk pada anak-anak antara Usia 0 - 8 tahun yang berada pada tahap perkembangan yang rentan dan sedang mengalami pertumbuhan yang cepat dan penting untuk kehidupan masa depan mereka. Salah satu aspek ketrampilan yang perlu di kembangkan adalah ketrampilan proses Sains. Oleh karena itu perlu adanya penggunaan model yang tepat sehingga ketrampilan proses Sains pada anak tercapai secara optimal. Penelitian ini bertujuan untuk mengetahui sejauh mana peningkatan Ketrampilan proses Sains dengan menggunakan model pembelajaran ATIK. Metode yang di gunakan dalam penelitian ini adalah metode Kualitatif dengan pendekatan diskriptif. Teknik pengumpulan data dengan menggunakan cara Observasi, Wawancara dan dokumen foto yang mendukung. Analisis data menggunakan analisis Diskriptif Kualitatif dengan model Miles dan Huberman. Penggunaan Model ATIK terbukti dapat Meningkatkan Ketrampilan Proses Sains di TK Islam Baitushshobirin.
The Use of The Round-Robin Technique on Students’ Vocabulary Mastery for The Second Graders of SMK Al Maksum Langkat
Authors: Malau Khairunnisa Br. , Rahmadhani Maitri , Suprayetno Edi 
Published: April 2023

The objective of this research was to determine whether the Round Robin technique significantly affects students’ vocabulary mastery for the second graders of SMK AL Maksum Langkat. A quasi-experimental research design was used in this study. There were 51 students taken as sample by using purposive sampling technique from 116 populations of second graders of SMK AL Maksum Langkat. There were 28 students from class XI OTKP as a control class, and 23 students from class XI as an experimental class. There were six meetings conducted by the researcher which consisted of one meeting for pre-test, four meetings for treatments, and one meeting for the post-test. The Round Robin technique was applied to the experimental class and the conventional technique was applied in the control class. From the analysis of the data by using Independent Sample T-test in SPSS 25.00 it was found that the data were in normal distribution and had the same variance or homogenous. The result of the hypothesis test showed that the students’ mean score of pre-test was lower than the post-test (79,30 > 53,11) and the Sig. (p value) < ? = 0.05 (0,000 < 0,05), it can be said that H0 was rejected and Ha was accepted. it can be concluded that there was a significant effect of using the Round Robin technique on students’ vocabulary mastery in the second graders of SMK AL Maksum Langkat.
Respon bibit kelapa sawit terhadap aplikasi urea berlapis zeolit sebagai pupuk slow release nitrogen
Authors: Kautsar Valensi , Hangger Gahara Mawandha , Aldymas Bimantara 
Published: April 2023

Nitrogen merupakan unsur hara esensial, oleh karenanya ketersediaan nitrogen anorganik sangat penting dalam mendukung perkembangan bibit kelapa sawit. Adanya sifat urea yang lepas cepat, menyebabkan urea mudah hilang sebelum diserap oleh tanaman. Berbagai upaya telah dilakukan untuk mengubah sifat urea dari lepas cepat menjadi lepas lambat. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas pelapisan urea dengan zeolit dengan metode yang mudah. Urea dengan lapisan zeolit dibandingkan dengan urea tanpa lapisan zeolit selama tiga bulan aplikasi pemupukan bibit sawit main nursery. Penelitian ini menggunakan dua jenis zeolit yaitu zeolit non aktivasi dan zeolit aktivasi, dengan dua persentase yaitu 20% dan 40%. Adanya pelapisan zeolit menyebabkan penurunan higroskopisitas urea dan kelarutan urea pada larutan aquades. Selain itu pelapisan urea pada berbagai persentase dan berbagai tipe zeolit mampu menghasilkan pertumbuhan yang sama baiknya dengan pupuk urea tanpa zeolit. Hal ini menunjukkan bahwa baik zeolit yang diaktivasi maupun non aktivasi dapat dimanfaatkan dalam pelapisan urea yang berdampak pada penurunan jumlah dosis urea yang digunakan dalam pembibitan.
De waardering van de letselschadezitting: een verkenning
Authors: van Eekeren P.J. 
Published: April 2023

De waardering van de letselschadezitting: een verkenning.
Op 3 oktober 2022 vond voor de 15e keer het jaarlijkse Gronings letselschadecongres plaats, met als thema ‘de prijs van letselschade’. Traditiegetrouw spreekt daar een rechter als hekkensluiter. Deze keer was het de beurt aan Ellen van Eekeren. Zij nam, eendachtig het thema van dit congres, de deelnemers mee voor een kijkje in de rechterlijke keuken als het gaat om de zitting, en dan in het bijzonder ‘de letselschadezitting’. Zij verkende met hen de diverse factoren die de waarde van de letselschadezitting bepalen.
Design and Implementation of a Secure Virtual Private Network Over an Open Network (Internet)
Authors: Forbacha Suh Charles , Agwu Mbuya Josiah Anyam 
Published: April 2023

Aim: The main objective of this research project is to design and implement a functional secure virtual private network over the internet considering that use of traditional fixed telephones lines is not cost effective and it is unsecured especially in the context of Cameroon.
Methods: In the VPN, internet is used as the data pipelined replacing the traditional data lines. This approach was deployed through simulation with CISCO Packet Tracer.
Results: Simulation results showed that the system can provide a secured, reliable and cost effective transmission system over the Internet for organizations in Cameroon. As such, VPNs form an integral part of remote business communications across the internet due to the inherent risks that exist when sending private information over a public network.
Conclusion: VPNs not only prevent unethical use of private business correspondence by unauthorized parties but they also play an important role in reducing the environmental impact of business travel.
Recommendations: This study recommend an organization which considers security as its top priority to embrace the rather expensive solution of implementing an email/Web/DNS/FTP server at each site rather than using only a single email/web/DNS/FTP server for the entire intranet. This will reduce the amount of information that organization sends across the Internet and increase information access speeds. Home users or small office can equally be installed with an email/web/DNS/FTP server. Also, in the remote access case, a company can outsource the installation and management of their remote access VPN server to the ISP. Moreover, just using IPSec for remote access users is not enough. Remote access IPSec VPN implementation should always be associated with a tunneling protocol such as PPTP.
Effect of Organic and Inorganic Fertilizer on Vegetative Growth Parameter of Lilium (Lilium Longiflorum) cv. Pavia under Shade Net Condition
Authors: Kumar Narendra , Prasad V. M. , Kerketta Anita , Das Kanchan S. 
Published: April 2023

The present investigation entitled, “Effect of Organic and Inorganic Fertilizer on Vegetative Growth Parameter of Lilium (Lilium Longiflorum) cv. Pavia Under Shade Net Condition” was under taken in the Department of Horticulture, Naini Agricultural Institute, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, (Allahabad). During winter season of 2020-2021, 2021-2022 and Pooled. The experiment was layout in Randomized Block Design (RBD) with 13 treatments and each treatment replicated thrice. The treatments consist of different combinations of inorganic fertilizers (N, P and K) and organic fertilizers (FYM, Vermicompost and Poultry Manure) and control (No fertilizers and manures). The treatment T5 50% RDF + FYM 14 t ha-1 was found the statistically significant compared to other treatment combination, which recorded highest plant height (23.68, 57.11 and 76.41 cm), spread area (8.19 cm2, 15.54 cm2 and 18.47 cm2), Number of leaves (36.63, 57.11 and 76.41), Leaf area (15.03 cm2, 15.63 cm2 and 15.33 cm2), Chlorophyll content (66.11 mg, 65.60 mg and 65.86 mg), followed by T9 25% RDF + Vermicompost 6.9 t ha-1 and lowest yield was obtained from T0 (control).
Microenvironmental Changes in Mediastinal Fat-associated Lymphoid Clusters and Lungs in Early and Late Stages of Metastatic Lung Cancer Induction
Authors: Elewa Yaser Hosny Ali , Abd Elwakil Mahmoud M , Harashima Hideyoshi , Mohamed Sherif Kh A , Zahran Mahmoud Hosny 
Published: April 2023

Abstract
The prognosis of metastatic lung melanoma (MLM) has been reported to be poor. An increasing number of studies have reported the function of several immune cells in cancer regression. Although the function of mediastinal fat-associated lymphoid clusters (MFALCs) in the progression of inflammatory lung lesions has been previously reported, the association between MLM progression and MFALCs development has remained unexplored. Herein, we compared the microenvironmental changes in the lungs and MFALCs among phosphate-buffered saline (PBS) and cancer groups at early (1 week) and late (2 weeks) stages following the intravenous injection of B16-F10 melanoma cells into C57BL/6 mice. Except for lung CD4+ helper T-cells and Iba1+ macrophage populations of early stage, we observed a significant increase in the proliferating and immune cell (CD20+ B-lymphocytes, CD3+ T-lymphocytes, CD8+ cytotoxic T-cells, CD16+ natural killer (NK) cells populations, area of high endothelial venules, and lung lymphatic vessels in cancer groups at both the stages as compared with the PBS groups. Furthermore, a significant positive correlation was observed between immune cell populations in MFALCs and the lungs (B- and T-lymphocytes, and NK cells in both stages). Collectively, our findings suggest a promising cancer therapeutic strategy via targeting immune cells in MFALCs.
Gender, workplace preferences and firm performance: Looking through the glass door
Authors: Chen Jie , Jing Chenxing , Keasey Kevin , Lim Ivan , Xu Bin 
Published: April 2023

AbstractUsing Glassdoor data we show that women are less satisfied at work than men and that female employees care more about work‐life balance. Further analysis shows that this gender difference in workplace preference vanishes at the manager level, suggesting that women who care less about work‐life balance self‐select into career paths that ultimately lead to management positions. Exploring the performance implications, we show that family‐friendly workplaces with smaller gender gaps in work‐life balance satisfaction are associated with better firm performance. Overall, our study implies that policies that aim to narrow the gender satisfaction gap can be socially and economically desirable.
Successful ablation of a right epicardial accessory pathway via the right ventricular diverticulum in a patient with Wolff‐Parkinson‐White syndrome
Authors: Zhang Zhijun , Ma Changsheng , Li Xuewen , Qu Lijuan , Zhao Bingye , Bai Rong 
Published: April 2023

AbstractIntroductionWe describe one rare case of successful ablation of a right epicardial accessory pathway (AP) via the right ventricular diverticulum in a patient with Wolff‐Parkinson‐White syndrome.MethodsA 42‐year‐old woman was referred to the hospital for a catheter ablation of Wolf‐Parkinson‐White syndrome. The earliest activation was shown to be present in the region of the tricuspid annulus. However, ablation had no effect on the AP.ResultsWe decided to do a selected angiography, in which a big diverticulum near the right tricuspid annulus was shown to be present. Ablation in this region successfully repressed the AP without any recurrences within a follow‐up period of 12 months.ConclusionThe ventricular diverticulum‐mediated AP is a novel variant of pre‐excitation. It can serve as an anatomical substrate of supraventricular tachycardia, and can be ablated endocardially using an irrigation tip catheter within the diverticulum.
Supplemtary Figures S 1-14 from SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer
Authors: Zwart Wilbert , Flach Koen D. , Rudraraju Bharath , Abdel-Fatah Tarek M.A. , Gojis Ondrej , Canisius Sander , Moore David , Nevedomskaya Ekaterina , Opdam Mark , Droog Marjolein , Hofland Ingrid , Chan Steve , Shaw Jacqui , Ellis Ian O. , Coombes R. Charles , Carroll Jason S. , Ali Simak , Palmieri Carlo 
Published: April 2023

<p>S1: Image of full size blot for figure 1A; S2: Image of full size blot for figure 1B; S3: SRC3-pS543 and SRC3 chromatin binding patterns in MCF7 cells; S4: Venn diagram of SRC1, SRC2 and SRC3-pS543 enriched binding sites; S5: A. ChIP-QPCR validation of differential enriched chromatin binding sites for total SRC3 and SRC3-pS543; S6: Hormone dependence and phospho-specificity of SRC3-pS543 at sites either or not shared with total SRC3; S7: Overlap of ERïƒ¡ï€ and SRC3 with other publically available datasets; S8: Fulvestrant decreases SRC3-pS543/chromatin interactions at sites shared with ERïƒ¡; S9: Venn diagram, showing the overlap of GO pathways enriched for genes proximal to chromatin binding sites for SRC3-pS543 unique, SRC3 unique or shared regions; S10: 2D graph of normalized ChIP-seq data, illustrating signal for ERïƒ¡, total SRC3, H3K4me1, H3K4me2, H3K4me3 and H3K27Ac binding events at genomic regions occupied by SRC3-pS543; S11: Histological analysis of SRC3 and SRC3-pS543 expression in representative tumour sections; S12: Scatterplot analysis for total SRC3 versus SRC3-pS543 signal in the Nottingham Tenovus Primary Breast Carcinoma Series; S13: Disease Free Survival and breast cancer specific survival in breast cancer patients based on SRC3 protein expression; S14: Disease Free Survival and breast cancer specific survival in patients with HER2 positive and SRC3 high breast cancers compared with all other patients.</p>