bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co-designing a health promotion program for Australian Aboriginal and Torres Strait Islander girls: lessons learnt
Authors: English Madeleine , Canuto Karla , Schulenkorf Nico , Evans John , Curry Christina , Slater Cain , Caperchione Cristina M 
Published: March 2023

SummaryDespite progression in the ethical and methodological conduct of Aboriginal and Torres Strait Islander health research, disparities still pervade, indicating limitations in knowledge translation. One identified gap is a lack of documented experiences detailing how ethical guidelines may be practically applied. This paper aims to (i) describe the research processes involved in co-designing a physical activity and psychosocial health program for Aboriginal and Torres Strait Islander girls and (ii) highlight learnings of the collaborative research journey. The Criteria for Strengthening Reporting of Health Research involving Indigenous Peoples (CONSIDER) statement was used to document participatory research activities undertaken with an Aboriginal community partner. Building upon the CONSIDER statement, Aboriginal (N = 3), Torres Strait Islander (N = 1) and non-Indigenous (N = 4) research team members engaged in critical reflection to identify lessons learnt. Researchers identified a tension between participatory research principles and the expectations of funding agencies and research institutions. Consequently, timelines must be flexible to foster meaningful community engagement and participatory processes. Additionally, researchers and community stakeholders are encouraged to embrace tensions that may associated with participatory research or the pressures Aboriginal and Torres Strait Islander researchers face from their community and organization. Furthermore, differences in professional (i.e. occupational) and cultural knowledge systems need to be acknowledged and accounted for within the early stages of a project to ensure informed decision-making. Identified lessons will assist relevant stakeholders in the development of future Aboriginal and Torres Strait Islander health programming, ensuring the most appropriate health solutions are devised with community.
Antibiotic-induced degradation of antitoxin enhances the transcription of acetyltransferase-type toxin-antitoxin operon
Authors: Li Peifei , Goh Ying-Xian , Ilic Bojana , Tai Cui , Deng Zixin , Chen Zhaoyan , Djordjevic Marko , Ou Hong-Yu 
Published: March 2023

AbstractBackgroundBacterial toxin-antitoxin (TA) modules respond to various stressful conditions. The Gcn5-related N-acetyltransferase-type toxin (GNAT) protein encoded by the GNAT-RHH TA locus is involved in the antibiotic tolerance of Klebsiella pneumoniae.ObjectivesTo investigate the transcriptional mechanism of the GNAT-RHH operon kacAT under antibiotic stress.MethodsThe transcriptional level of the kacAT operon of K. pneumoniae was measured by quantitative real-time (qRT) PCR assay. The degradation of antitoxin KacA was examined by western blot and fluorescent protein. The ratio of [KacA]:[KacT] was calculated by the fluorescence intensity of KacA-eGFP and mCherry-KacT. Mathematical modelling predicted protein and transcript synthesis dynamics.ResultsA meropenem-induced increase in transcript levels of kacA and kacT resulted from the relief from transcriptional autoregulation of the kacAT operon. Meropenem induces the degradation of KacA through Lon protease, resulting in a reduction in the ratio of [KacA]:[KacT]. The decreased ratio causes the dissociation of the KacAT complex from its promoter region, which eliminates the repression of kacAT transcription. In addition, our dynamic model of kacAT expression regulation quantitatively reproduced the experimentally observed reduction of the [KacA]:[KacT] ratio and a large increase in kacAT transcript levels under the condition of strong promoter autorepression by the KacAT complex.ConclusionsMeropenem promotes the degradation of antitoxin by enhancing the expression of Lon protease. Degradation of antitoxin reduces the ratio of intracellular [antitoxin]:[toxin], leading to detachment of the TA complex from its promoter, and releasing repression of TA operon transcription. These results may provide an important insight into the transcriptional mechanism of GNAT-RHH TA modules under antibiotic stress.
Predicate counterparts of modal logics of provability: High undecidability and Kripke incompleteness
Authors: Rybakov Mikhail 
Published: March 2023

Abstract
In this paper, the predicate counterparts, defined both axiomatically and semantically by means of Kripke frames, of the modal propositional logics $\textbf {GL}$, $\textbf {Grz}$, $\textbf {wGrz}$ and their extensions are considered. It is proved that the set of semantical consequences on Kripke frames of every logic between $\textbf {QwGrz}$ and $\textbf {QGL.3}$ or between $\textbf {QwGrz}$ and $\textbf {QGrz.3}$ is $\Pi ^1_1$-hard even in languages with three (sometimes, two) individual variables, two (sometimes, one) unary predicate letters, and a single proposition letter. As a corollary, it is proved that infinite families of modal predicate axiomatic systems, based on the classical first-order logic and the modal propositional logics $\textbf {GL}$, $\textbf {Grz}$, $\textbf {wGrz}$ are not Kripke complete. Both $\Pi ^1_1$-hardness and Kripke incompleteness results of the paper do not depend on whether the logics contain the Barcan formula.
Provider Ownership and Indicators of Service Quality: Evidence from Swedish Residential Care Homes
Authors: Broms Rasmus , Dahlström Carl , Nistotskaya Marina 
Published: March 2023

Abstract
The provision of public services by for-profit and non-profit organizations is widespread in OECD countries, but the jury is still out on whether outsourcing has improved service quality. This article seeks to nuance existing debate by bringing to the fore variation in service quality between different types of non-public providers. Building on theories of dimensional publicness and incomplete contracts, we argue that different forms of non-public ownership are associated with varying intensity of incentives for profit maximization, ultimately affecting service quality. Using residential elder care homes in Sweden as our universe of cases, we leverage novel panel data for 2,639 facilities from 2012 to 2019, capturing the ownership type of the care home operators, against a set of indicators pertaining to inputs, processes, and outcomes. The results suggest that non-public providers with high-powered incentives to make profit, such as those owned by private equity firms and publicly traded companies, perform worse on most of the selected indicators compared to private limited liability companies and nonprofits. Our findings that the intensity of quality-shading incentives is not the same for all non-public providers have important implications for government contracting and contract management.
Limonin delays the progression of intervertebral disc degeneration in vivo and in vitro: the key role of the MAPK/NF-κB and necroptosis pathways
Authors: Gong Yuhang , Jiang Ting , Lu Fangying , Sun Jiacheng , Xu Wangjin , Qiu Jianxin , Zhang Weikang , Zheng Xiaohang , Yang Guangyong , Chu Binxiang , Ye Jiajing , Mi Shuang , Hong Zhenghua 
Published: March 2023

Abstract

Objectives
Limonin has received significant attention due to its multiple biological effects, intervertebral disc degeneration (IDD) is also of interest due to the high prevalence of this disease. In this study, we determined the effects of limonin on IDD and the underlying mechanism of action to find novel ways to treat IDD.

Methods
An IL-1β-induced cell inflammation model and a lumbar instability model inducing IDD were established to assess the progression of IDD with or without limonin treatment. We further evaluated MAPK/NF-κB and necroptosis pathways and alterations in the extracellular matrix specific within the disc.

Key findings
Limonin suppresses inflammation in the nucleus pulposus in vitro by reducing the production of pro-inflammatory markers such as iNOS and COX-2. Limonin reduced the activation of the MAPK/NF-κB signalling pathway and the RIP1/RIP3/MLKL necroptosis pathway in the NP cells. Moreover, limonin delays the IDD progression in the lumbar instability model.

Conclusions
Limonin could potentially delay IDD by inhibiting NP cell necroptosis and modulating peripheral matrix proteins within the intervertebral disc and is a potential pharmacological research direction for the therapy in patients with IDD.
Urine Protein Immunofixation Electrophoresis: Free Light Chain Urine Immunofixation Electrophoresis Is More Sensitive than Conventional Assays for Detecting Monoclonal Light Chains and Could Serve as a Marker of Minimal Residual Disease
Authors: Singh Gurmukh , Arinze Nkechi , Manthei David M , Plapp Frederick V , Bollag Roni J 
Published: March 2023

Abstract

Background
Immunoglobulin monoclonal light chains (MLCs) in serum and urine are markers for monoclonal gammopathy and could serve as markers of minimal residual disease (MRD) in multiple myeloma (MM). Excretion of MLCs in urine is known to result in renal damage and shorter survival in patients with LC-predominant MM.

Methods
Retrospective review of urine immunofixation in 1738 specimens at 3 medical centers was conducted to assess the utility of urinalysis for diagnosis and monitoring of monoclonal gammopathy. We tested 228 stored urine specimens via the modified urine immunofixation method, using antisera to assay free LCs (FLCs).

Results
Our review of urine immunofixation results and medical records validated the theory that the only meaningful value-added finding was detection of monoclonal free light chains. Examination of 228 urine specimens using our novel method revealed 18.4% additional positive results. The rate of incremental findings for lambda LCs was nearly 3-fold higher than for kappa LCs.

Conclusions
The new method of urine immunofixation is significantly more sensitive and more efficient than the conventional method for detecting MLCs in urine. The new assay appears to be sensitive enough to prove that MLCs serve as a marker of MRD in MM.
Search for subsolar-mass black hole binaries in the second part of Advanced LIGO’s and Advanced Virgo’s third observing run
Authors:   The LVK Collaboration
Published: March 2023

ABSTRACT
We describe a search for gravitational waves from compact binaries with at least one component with mass $0.2$–$1.0 \, \mathrm{M}_\odot$ and mass ratio q ≥ 0.1 in Advanced Laser Interferometer Gravitational-Wave Observatory (LIGO) and Advanced Virgo data collected between 2019 November 1, 15:00 utc and 2020 March 27, 17:00 utc. No signals were detected. The most significant candidate has a false alarm rate of $0.2 \, \rm {yr}^{-1}$. We estimate the sensitivity of our search over the entirety of Advanced LIGO’s and Advanced Virgo’s third observing run, and present the most stringent limits to date on the merger rate of binary black holes with at least one subsolar-mass component. We use the upper limits to constrain two fiducial scenarios that could produce subsolar-mass black holes: primordial black holes (PBH) and a model of dissipative dark matter. The PBH model uses recent prescriptions for the merger rate of PBH binaries that include a rate suppression factor to effectively account for PBH early binary disruptions. If the PBHs are monochromatically distributed, we can exclude a dark matter fraction in PBHs $f_\mathrm{PBH} \gtrsim \, 0.6$ (at 90 per cent confidence) in the probed subsolar-mass range. However, if we allow for broad PBH mass distributions, we are unable to rule out fPBH = 1. For the dissipative model, where the dark matter has chemistry that allows a small fraction to cool and collapse into black holes, we find an upper bound fDBH &lt; 10−5 on the fraction of atomic dark matter collapsed into black holes.
UV-FIR SED modelling of AGNs in IR-luminous galaxies up to z ∼ 2.5: understanding the effects of torus models
Authors: Sokol Alyssa D , Yun M , Pope A , Kirkpatrick A , Cooke K 
Published: March 2023

ABSTRACT
UV-FIR spectral energy distribution (SED) modelling is an effective way to disentangle emission between star formation (SF) and active galactic nuclei (AGNs) in galaxies; however, this approach becomes uncertain for composite AGNs/SF galaxies that comprise 50–70 per cent of IR-samples. Cosmic X-ray background (XRB) models require a large fraction of obscured AGNs to reproduce the observed XRB peak, motivating reliable SED analyses in objects where the AGNs may be ‘buried’ in the galaxy and in the mid-IR to far-IR SED. In this paper, we study a 24 $\mu$m-selected (S24 &gt; 100 $\mu$Jy) sample of 95 galaxies with $0~{{\ \rm per\ cent}} \lt f_{\mathrm{ MIR},\mathrm{ AGN}} \lt 100~{{\ \rm per\ cent}}$, 0.4 &lt; z &lt; 2.7, and 1011L⊙ &lt; LIR &lt; 1013L⊙. We test the performance of AGN models ranging in torus optical depth via SED fitting, comparing results with Spitzer mid-infrared spectroscopy and X-ray observations. The best-fitting torus optical depth can shed light on whether these galaxies host a luminous obscured AGN population. We find that permitting a broader AGN SED parameter space results in improved fit quality with higher optical depths, higher FIR AGN contributions, and higher LBol, impacting the bright end of the LBol luminosity function. Our results suggest there may be a population of dust-obscured composites that are bolometrically significant but have their AGNs mostly hidden in the mid-IR SED. If so, literature applications of SED fitting that often simplify AGN models or omit optically thick tori may largely underestimate AGN contribution from composite sources, as these sources are both numerous and have solutions sensitive to the assumed range of AGN models.
Study of central light distribution in nearby early-type galaxies hosting nuclear star clusters
Authors: Sruthi K , Ravikumar C D 
Published: March 2023

ABSTRACT
We present analysis of 63 nearby (&lt;44 Mpc) early-type galaxies hosting nuclear star clusters using the recently discovered parameter central intensity ratio (CIRI) determined from near-infrared (3.6 $\mu$m) observations with the Infrared Array Camera of Spitzer Space Telescope. The CIRI, when combined with filters involving age and B − K colour of host galaxies, helps identify two distinct classes of galaxies hosting nuclear star clusters. This is independently verified using Gaussian mixture model. CIR shows a positive trend with faint, low-mass, and blue galaxies in the sample, while the opposite is true for bright, high-mass, and red galaxies, albeit with large scatter. The variation of CIRI with central velocity dispersion, absolute B-band magnitude, dynamical mass, and stellar mass of host galaxies suggests that the mass of nuclear star clusters increases with that of host galaxies, for faint, low-mass, young, and blue galaxies in the sample. In bright, high-mass, old, and red galaxies, on the other hand, the evolution of nuclear star clusters appears complex, with no apparent trends. The analysis also reveals that redder galaxies (B − K &gt; 3.76) are more likely to be dominated by the central black hole than the nuclear star clusters, while for bluer galaxies (B − K &lt; 3.76) in the sample the situation is quite opposite.
The occurrence rate of giant planets orbiting low-mass stars withTESS
Authors: Bryant Edward M , Bayliss Daniel , Van Eylen Vincent 
Published: March 2023

ABSTRACTWe present a systematic search for transiting giant planets ($0.6 \mbox{$R_{\rm J}$}\le \mbox{$R_{\rm P}$}\le 2.0 \mbox{$R_{\rm J}$}$) orbiting nearby low-mass stars ($\mbox{$M_{*}$}\le 0.71 \mbox{${\rm M}_{\odot }$}$). The formation of giant planets around low-mass stars is predicted to be rare by the core-accretion planet formation theory. We search 91 306 low-mass stars in the TESS 30 min cadence photometry detecting fifteen giant planet candidates, including seven new planet candidates which were not known planets or identified as TOIs prior to our search. Our candidates present an exciting opportunity to improve our knowledge of the giant planet population around the lowest mass stars. We perform planet injection-recovery simulations and find that our pipeline has a high detection efficiency across the majority of our targeted parameter space. We measure the occurrence rates of giant planets with host stars in different stellar mass ranges spanning our full sample. We find occurrence rates of 0.137 ± 0.097  per cent (0.088–0.26 M⊙), 0.108 ± 0.083 per cent (0.26–0.42 M⊙), and 0.29 ± 0.15 per cent (0.42–0.71 M⊙). For our full sample (0.088–0.71 M⊙), we find a giant planet occurrence rate of 0.194 ± 0.072 per cent. We have measured for the first time the occurrence rate for giant planets orbiting stars with $\mbox{$M_{*}$}\le 0.4\, \mbox{${\rm M}_{\odot }$}$ and we demonstrate this occurrence rate to be non-zero. This result contradicts currently accepted planet formation models and we discuss some possibilities for how these planets could have formed.
Quantum mechanical line widths of ionized oxygen, silicon, and aluminium; comparisons with recent experimental results
Authors: Elabidi H , Sahal-Bréchot S , Dimitrijević M S , Hamdi R , Belhadj W 
Published: March 2023

ABSTRACT
We present in this paper new quantum Half Widths at Half intensity Maximum (HWHM) for 101 spectral lines of the following ions: O II (35 lines), O III (20 lines), Si II (9 lines), Si III (12 lines), and Al III (25 lines). The present quantum results are compared to new experimental ones. No previous quantum calculations have been performed for these ions. The relatively high differences found between the new and previous measurements and the available theoretical calculations encourage us to conduct these quantum calculations. Our quantum method has been used many years ago and has given good results compared to other approaches, so it can be a useful tool to check the new experimental results or to understand the disagreement found for some lines. Furthermore, the obtained results can be used for the abundance determination of elements, the calculation of stellar opacity, the interpretation and modelling of stellar spectra, and the estimation of the relative transfer through stellar plasmas, etc. Part of the present results will be also implemented to the data base of Stark broadening parameters STARK-B.
Switching integrators reversibly in the astrophysical N-body problem
Authors: Hernandez David M , Dehnen Walter 
Published: March 2023

ABSTRACT
We present a simple algorithm to switch between N-body time integrators in a reversible way. We apply it to planetary systems undergoing arbitrarily close encounters and highly eccentric orbits, but the potential applications are broader. Upgrading an ordinary non-reversible switching integrator to a reversible one is straightforward and introduces no appreciable computational burden in our tests. Our method checks whether the integrator during the time-step violates a time-symmetric selection condition and redoes the step if necessary. In our experiments, a few per cent of steps would have violated the condition without our corrections. By eliminating them, the algorithm avoids long-term error accumulation, of several orders of magnitude in some cases.
Roles of glutathione peroxidase 4 on the mercury-triggered ferroptosis in renal cells: implications for the antagonism between selenium and mercury
Authors: Chen Jiahao , Ma Minghao , Wang Ruixia , Gao Ming , Hu Ligang , Liu Sijin , Xu Ming 
Published: March 2023

AbstractUnderstanding of how mercury species cause cellular impairments at the molecular level is critical for explaining the detrimental effects of mercury exposure on the human body. Previous studies have reported that inorganic and organic mercury compounds can induce apoptosis and necrosis in a variety of cell types, but more recent advances reveal that mercuric mercury (Hg2+) and methylmercury (CH3Hg+) may result in ferroptosis, a distinct form of programmed cell death. However, it is still unclear which protein targets are responsible for ferroptosis induced by Hg2+ and CH3Hg+. In this study, human embryonic kidney 293T cells were used to investigate how Hg2+ and CH3Hg+ trigger ferroptosis, given their nephrotoxicity. Our results demonstrate that glutathione peroxidase 4 (GPx4) plays a key role in lipid peroxidation and ferroptosis in renal cells induced by Hg2+ and CH3Hg+. The expression of GPx4, the only lipid repair enzyme in mammal cells, was downregulated in response to Hg2+ and CH3Hg+ stress. More importantly, the activity of GPx4 could be markedly inhibited by CH3Hg+, owing to the direct binding of the selenol group (–SeH) in GPx4 to CH3Hg+. Selenite supplementation was demonstrated to enhance the expression and activity of GPx4 in renal cells, and consequently relieve the cytotoxicity of CH3Hg+, suggesting that GPx4 is a crucial modulator implicated in the Hg–Se antagonism. These findings highlight the importance of GPx4 in mercury-induced ferroptosis, and provide an alternative explanation for how Hg2+ and CH3Hg+ induce cell death.
Parathyroidectomy versus oral cinacalcet on cardiovascular parameters in peritoneal dialysis patients with advanced secondary hyperparathyroidism (PROCEED): a randomized trial
Authors: Wang Angela Yee-Moon , Lo Wai Kei , Cheung Stephen Chi-Wai , Tang Tak-Ka , Yau Yat-Yin , Lang Brian Hung-Hin 
Published: March 2023

Abstract

Background
This trial aimed to evaluate oral cinacalcet versus total parathyroidectomy (PTx) with forearm autografting on cardiovascular surrogate outcomes and health-related quality of life (HRQOL) measures in dialysis patients with advanced secondary hyperparathyroidism (SHPT).

Design
In this pilot prospective randomized trial conducted in two university-affiliated hospitals, 65 adult peritoneal dialysis patients with advanced SHPT were randomized to receive either oral cinacalcet or PTx. Primary endpoints were changes in left ventricular (LV) mass index by cardiac magnetic resonance imaging and coronary artery calcium scores (CACS) over 12 months. Secondary endpoints included changes in heart valves calcium scores, aortic stiffness, biochemical parameters of chronic kidney disease-mineral bone disease (CKD-MBD) and HRQOL measures over 12 months.

Results
Changes in LV mass index, CACS, heart valves calcium score, aortic pulse wave velocity and HRQOL did not differ between groups or within groups, despite significant reductions in plasma calcium, phosphorus and intact parathyroid hormone in both groups. Cinacalcet-treated patients experienced more cardiovascular-related hospitalizations than those who underwent PTx (P = .008) but the difference became insignificant after adjusting for baseline difference in heart failure (P = .43). With the same monitoring frequency, cinacalcet-treated patients had fewer hospitalizations due to hypercalcemia (1.8%) than patients who underwent PTx (16.7%) (P = .005). No significant changes were observed in HRQOL measures in either group.

Conclusions
Both cinacalcet and PTx effectively improved various biochemical abnormalities of CKD-MBD and stabilized but did not reduce LV mass, coronary artery and heart valves calcification, or arterial stiffness, or improve patient-centered HRQOL measures in PD patients with advanced SHPT. Cinacalcet may be used in place of PTx for treating advanced SHPT. Long-term and powered studies are required to evaluate PTx versus cinacalcet on hard cardiovascular outcomes in dialysis patients.
Trial registration: ClinicalTrials.gov identifier: NCT01447368.