bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Industry 4.0 adoption to innovation ambidexterity to firm performance: a MASEM analysis
Authors: Oduro Stephen , De Nisco Alessandro 
Published: June 2023

PurposeInformed by the resource-based view of the firm, dynamic capabilities theory and contingency theory, this study examines the impact of Industry 4.0 (IR4.0) technologies adoption on firm performance (FP) while accounting for the mediating role of innovation ambidexterity (IA) and moderating roles of contextual and methodological factors that drive the performance gains of the phenomenon.Design/methodology/approachA random-effect model in comprehensive meta-analysis (CMA) is used to synthesize 113 studies in 115 independent samples with 192,188 observations.FindingsThis analysis demonstrates that IR4.0 digital technologies are directly related to financial and non-financial performance, disclosing that the performance effect on non-financial is the largest. Moreover, there is a complementary partial mediation role of the impacts of IR4.0 on FP by IA. Furthermore, this focal relationship is moderated by boundary-spanning conditions: contextual factors – firm size, business type, economic development, industry sector and methodological factors – proxy of FP, sample size and study type.Practical implicationsThe results imply that IR4.0 produces financial and non-financial benefits by enabling firms to develop dynamic capabilities like innovation ambidexterity, which informs managers and practitioners that unless IR4.0 technologies and IA strategies are combined together to generate superior FP, IR4.0, in and of itself, would produce a less positive impact on FP than the combined impact of IR4.0 and IA. Therefore, managers should focus on converting IR4.0 resources to dynamic capabilities like IA by leveraging open innovation strategies or building IR4.0-based coordination mechanisms by creating cross-unit business synergies.Originality/valueTo the best of the authors' knowledge, per the literature review, this is the first meta-analysis structural equation modeling study on the interplay between IR4.0, innovation ambidexterity and firm performance.
Examining the effect of technology-related divestitures on exploratory innovation: evidence from China
Authors: Wu Xintong , Gao Yuchen , Hu Yimei 
Published: June 2023

PurposeThis study aims to test the effects of Technology-related Divestitures (TRDs) on firms' exploratory innovation. The moderating effects of firms' internal and external resource coordination activities, resource buffering and bridging, are also explored.Design/methodology/approachA set of data including 1,372 Chinese listed firms from 2009 to 2018 is adopted. Based on propensity score matching sample, random-effect Tobit models were employed to test the hypotheses.FindingsThe empirical results indicate that TRDs inhibit firms' exploratory innovation, while both resource buffering and bridging can mitigate this negative effect. This implies that to promote exploratory innovation, resource coordination activities are the essential.Originality/valueThe research findings can contribute to both the exploratory innovation and technological divestiture literature. The test on the moderating roles of resource buffering and bridging can also extend our understanding of the effect of TRDs on firms' exploratory innovation. Accordingly, several practical implications can be provided. This is especially important for strategic decisions of firms from emerging and developing countries, which often lack sufficient internal resources and strong technological capabilities to develop exploratory innovation.
Mediating customer engagement in the relationship between fast-food restaurants' innovativeness and brand evangelism during COVID-19: evidence from emergent markets
Authors: Khashan Mohamed A. , Elsotouhy Mohamed M. , Ashraf Aziz Mariam , Alasker Thamir Hamad , Ghonim Mohamed A. 
Published: June 2023

Purpose
The proliferation of the coronavirus disease (COVID-19) has threatened the service industry, especially the restaurant sector, requiring innovative ways to help restaurants overcome this challenge. Thus, based on the stimulus–organism–response (SOR) model, the purpose of this study is to examine the role of customers' perception of a restaurant's innovativeness (CPRI) in brand evangelism by mediating customer engagement (CE). Additionally, this study examines the moderating role of customer openness to experience.

Design/methodology/approach
A Web-based survey collected the primary data from 483 Egyptian customers. The data were analysed using the partial least squares structural equation modelling method based on WarpPLS.7 software.

Findings
According to the findings, CPRI, which acts as a stimulus in the SOR model, positively affects CE (organism) and brand evangelism (response). CE positively affects restaurant evangelism. Additionally, CE mediates the relationship between CPRI and evangelism. Openness to experience moderates the relationship between CPRI, engagement and brand evangelism.

Research limitations/implications
This study addresses the gaps in understanding CE and brand evangelism within the context of restaurant innovation. This study assesses restaurant innovativeness scales of developing economies in multiple dimensions. Egyptian restaurant marketing managers should innovate products, services, experiences, and promotions to increase consumer engagement and feedback through technology.

Originality/value
This study investigates how Egyptian restaurants engage with and evangelise customers through innovation. This is one of the few studies that examine brand evangelism in a restaurant setting from the perspective of the SOR theory. Additionally, this study analyses CE as a mediator and openness to experience as a moderator.
Measurement model of the projected and perceived image through the organizational identity of the Volvo Ocean Race Brazil event
Authors: Najdzion Lígia , Anjos Sara Joana Gadotti dos , Kuhn Vitor Roslindo , Anjos Francisco Antonio dos 
Published: June 2023

PurposeWorld Tourism Organization (WTO) recognizes image as the main aspect to be considered by a destination in its promotion and marketing process. Cities try to build valued and recognized images, established from an identity defined based on their own values. One of the strategies adopted for this construction is to hold events, through which it is possible to promote tourism, move the economy, improve the infrastructure, change the image and influence intentions to visit the destination. From the point of view of supply and demand, theorists have proposed two categories of destination image: the projected image and the perceived image. In this context, the objective of the research was to propose a model for measuring the Projected and Perceived Image through the Organizational Identity of the Volvo Ocean Race Brazil.Design/methodology/approachWith a quali-quantitative approach, the study universe is composed of in-depth interviews with the main members of the organizing committee, documentary and netnographic analysis of the event's social networks. For the analysis and interpretation of qualitative data, the collective subject discourse was used. Documentary and netnographic analysis were by means of deductive content analysis and correspondence analysis.FindingsThe results supported the three secondary hypotheses of the research, leading to confirm the central hypothesis that the constructed organizational identity, projected by the image, is perceived by visitors to the event studied.Originality/valueIt is understood as fundamental the expansion of studies regarding projected and perceived image, identity and the possibility of its application in tourist events, as social representations, as support also for the definition of management and marketing strategies.
Electronic word of mouth, brand image and young customers' online purchase intention during the COVID-19 pandemic
Authors: Hoang Le Nguyen , Tung Le Thanh 
Published: June 2023

PurposeThis study aims to identify the relationships between the electronic word of mouth (eWOM), brand image (Brand) and online purchase intention (INT) of young customers during the coronavirus disease 2019 (COVID-19) pandemic period.Design/methodology/approachThe covariance-based SEM and the multi-group invariance analysis (MGA) were applied to investigate the proposed model with the data collected via an online survey during the fourth wave of COVID-19 in Vietnam.FindingsThe results showed that eWOM quantity (eQuan) has a significant positive effect on eWOM credibility (eC) in the context of the COVID-19 pandemic. Furthermore, whereas Brand positively partially mediates the relationship between eQuan and INT, this construct plays a positively fully mediating role in the relationship between eC and INT. Finally, the results indicated that there is no significant difference in the invariance indicators related to the gender of respondents.Originality/valueThis study has some contributions not only to the theoretical framework for understanding the online purchase behaviour of young customers in the pandemic context, but also to the practical implications of how to use different dimensions of eWOM accordingly to enhance a company's brand image in the online business environment.
The moderating effect of gender on the relationship between apprenticeship and self-employment: evidence from a developing country
Authors: Mohammed Ibrahim , Abdul Rahaman Wassiuw , Darku Alexander Bilson , Baah-Boateng William 
Published: June 2023

Purpose
This study aims to examine the association between apprenticeship training and self-employment and how gender moderates the association.

Design/methodology/approach
Secondary data from the World Bank’s Skills Towards Employment and Productivity (STEP) survey on Ghana were analysed using a binary choice (logit regression) model. The STEP survey drew its nationally representative sample from the working-age population (15–64 years) in urban areas.

Findings
After controlling for several factors identified in the literature as determinants of self-employment, the results indicate that completing apprenticeship training increases the likelihood of being self-employed. However, women who have completed apprenticeship training are more likely to be self-employed than men.

Originality/value
By examining the moderating effect of gender on the association between apprenticeship training and self-employment, this study has offered new evidence that policymakers can use to promote self-employment, especially among women, to reduce the entrepreneurial gap between men and women.
Risk of herpes zoster according to past history in the general population: The Japanese Shozu herpes zoster study
Authors: Kawahira Kazuhiro , Imano Hironori , Yamada Keiko , Mori Yasuko , Asada Hideo , Okuno Yoshinobu , Yamanishi Koichi , Iso Hiroyasu 
Published: June 2023

AbstractImmunity is known to persist after vaccination for varicella zoster virus, but the duration of immunity in patients who develop herpes zoster (HZ) remains unknown. To investigate the association between a past history of HZ and its occurrence in the general population. The Shozu HZ (SHEZ) cohort study included data for 12 299 individuals aged ≥50 years with information on their HZ history. Cross‐sectional and 3‐year follow‐up studies were carried out to analyze the associations between a history of HZ (yes <10 years, yes ≥10 years, no) and the proportion of positive varicella zoster virus skin test results (erythema diameter ≥5 mm) and the risk of HZ after adjusting for potential confounding factors including age, sex, body mass index, smoking status, sleep duration, and mental stress. The incidences of positive skin test results were 87.7% (470/536) for individuals with a history of HZ <10 years ago, 82.2% (396/482) for those with a history of HZ ≥10 years, and 80.2% (3614/4509) for those with no history of HZ. The multivariable odds ratios (95% confidence intervals) of erythema diameter ≥5 mm were 2.07 (1.57–2.73) and 1. 39 (1.08–1.80) for individuals with a history <10 years and ≥10 years ago, respectively, compared with no history. The corresponding multivariable hazard ratios of HZ were 0.54 (0.34–0.85) and 1.16 (0.83–1.61), respectively. A past history of HZ <10 years ago may reduce the occurrence of HZ.
The role of aging and brain‐derived neurotrophic factor signaling in expression of base excision repair genes in the human brain
Authors: Lautrup Sofie , Myrup Holst Camilla , Yde Anne , Asmussen Stine , Thinggaard Vibeke , Larsen Knud , Laursen Lisbeth Schmidt , Richner Mette , Vægter Christian B. , Prieto G. Aleph , Berchtold Nicole , Cotman Carl W. , Stevnsner Tinna 
Published: June 2023

AbstractDNA damage is a central contributor to the aging process. In the brain, a major threat to the DNA is the considerable amount of reactive oxygen species produced, which can inflict oxidative DNA damage. This type of damage is removed by the base excision repair (BER) pathway, an essential DNA repair mechanism, which contributes to genome stability in the brain. Despite the crucial role of the BER pathway, insights into how this pathway is affected by aging in the human brain and the underlying regulatory mechanisms are very limited. By microarray analysis of four cortical brain regions from humans aged 20–99 years (n = 57), we show that the expression of core BER genes is largely downregulated during aging across brain regions. Moreover, we find that expression of many BER genes correlates positively with the expression of the neurotrophin brain‐derived neurotrophic factor (BDNF) in the human brain. In line with this, we identify binding sites for the BDNF‐activated transcription factor, cyclic‐AMP response element‐binding protein (CREB), in the promoter of most BER genes and confirm the ability of BDNF to regulate several BER genes by BDNF treatment of mouse primary hippocampal neurons. Together, these findings uncover the transcriptional landscape of BER genes during aging of the brain and suggest BDNF as an important regulator of BER in the human brain.
Postoperative buprenorphine continuation in stabilized buprenorphine patients: A population cohort study
Authors: Hauck Tanya S. , Ladha Karim S. , Le Foll Bernard , Wijeysundera Duminda N. , Kurdyak Paul 
Published: June 2023

AbstractBackground and AimsSudden discontinuation of buprenorphine in the treatment of opioid use disorder can increase the risk of subsequent relapse and overdose. Little is known about buprenorphine use in the perioperative period. The aim of this study was to determine the rate of buprenorphine continuation after hospital discharge following surgery and factors associated with continuation.DesignA population‐based retrospective cohort study was conducted using administrative data from Ontario, Canada, between 2012 and 2018. The cohort included individuals on continuous buprenorphine prior to surgery. Logistic regression modeling was used to estimate the association of buprenorphine continuation with demographic, opioid agonist treatment, surgical and health service use factors.SettingAdministrative databases from Institute for Clinical Evaluative Sciences (ICES) were used, which capture the Ontario, Canada, population. The data sets describe physician billing, monitoring of controlled substances and hospital discharges.ParticipantsAdults (≥ 18 years, n = 2176) had received a buprenorphine/naloxone product continuously for at least 60 days for the treatment of opioid use disorder and subsequently underwent a surgical procedure.MeasurementsContinuation (versus discontinuation) of buprenorphine prescriptions in the 14 days after surgical discharge was recommended. Exposures included demographic, comorbidity, opioid agonist treatment, surgical and health service use characteristics.FindingsAbout 176 (8.1%) of the 2176 patients discontinued buprenorphine after surgery. Inpatient surgery (versus ambulatory) was associated with reduced odds of continuation, with an unadjusted odds ratio (OR) of 0.17 [95% confidence interval (CI) = 0.12–0.25] and an adjusted OR of 0.16 (95% CI = 0.11–0.23) after accounting for age, sex, rural residence, neighborhood income quintile, Charlson comorbidity index, psychiatric hospitalizations in the past 5 years and recent dispensed supply of buprenorphine (number needed to harm of 6.6).ConclusionsIn Ontario, Canada, from 2012 to 2018, most patients receiving continuous preoperative buprenorphine therapy continued buprenorphine use after surgery. Inpatient surgery was a strong predictor of discontinuation compared with ambulatory procedures.
A European‐Japanese study on peach allergy: IgE to Pru p 7 associates with severity
Authors: Kallen E. J. J. , Revers A. , Fernández‐Rivas M. , Asero R. , Ballmer‐Weber B. , Barreales L. , Belohlavkova S. , de Blay F. , Clausen M. , Dubakiene R. , Ebisawa M. , Fernández‐Perez C. , Fritsche P. , Fukutomi Y. , Gislason D. , Hoffmann‐Sommergruber K. , Jedrzejczak‐Czechowicz M. , Knulst A. C. , Kowalski M. L. , Kralimarkova T. , Lidholm J. , Metzler C. , Mills E. N. C. , Papadopoulos N. G. , Popov T. A. , Purohit A. , Reig I. , Seneviratne S. L. , Sinaniotis A. , Takei M. , Versteeg S. A. , Vassilopoulou A. E. , Vieths S. , Welsing P. M. J. , Zwinderman A. H. , Le T. M. , Van Ree R. 
Published: June 2023

AbstractBackgroundPru p 3 and Pru p 7 have been implicated as risk factors for severe peach allergy. This study aimed to establish sensitization patterns to five peach components across Europe and in Japan, to explore their relation to pollen and foods and to predict symptom severity.MethodsIn twelve European (EuroPrevall project) and one Japanese outpatient clinic, a standardized clinical evaluation was conducted in 1231 patients who reported symptoms to peach and/or were sensitized to peach. Specific IgE against Pru p 1, 2, 3, 4 and 7 and against Cup s 7 was measured in 474 of them. Univariable and multivariable Lasso regression was applied to identify combinations of parameters predicting severity.ResultsSensitization to Pru p 3 dominated in Southern Europe but was also quite common in Northern and Central Europe. Sensitization to Pru p 7 was low and variable in the European centers but very dominant in Japan. Severity could be predicted by a model combining age of onset of peach allergy, probable mugwort, Parietaria pollen and latex allergy, and sensitization to Japanese cedar pollen, Pru p 4 and Pru p 7 which resulted in an AUC of 0.73 (95% CI 0.73–0.74). Pru p 3 tended to be a risk factor in South Europe only.ConclusionsPru p 7 was confirmed as a significant risk factor for severe peach allergy in Europe and Japan. Combining outcomes from clinical and demographic background with serology resulted in a model that could better predict severity than CRD alone.
Reconstructing complex peripatellar defects using the descending genicular artery perforator flap
Authors: Hsieh Yun‐Huan , Kalmin Doran , Motoroko Maitumelo Imeldah , Morsi Mohammed , Morsi Adel 
Published: June 2023

AbstractBackgroundComplex peripatellar defects are commonly reconstructed with free flaps or pedicled muscle flaps, whereas pedicled fasciocutaneous perforator flaps are commonly overlooked. The descending genicular artery perforator (DGAP) flap is a versatile flap that offers thin and pliable tissue that provides ideal ‘like with like’ peripatellar soft tissue defect reconstruction. This paper aims to demonstrate the safe use of a pedicled fasciocutaneous DGAP flap for extensive traumatic peripatellar defect reconstructions and to exhibit the surgical pearls via a case series.MethodsA retrospective cohort study of consecutive complex peripatellar reconstructions with DGAP flaps was conducted from January 2011 to December 2018. Patient demographics, medical comorbidities, aetiology/size/and location of the defects were reviewed. Flap, donor site, and overall surgical outcomes were clinically assessed and documented. Descriptive statistics were conducted and analysed by IBM SPSS Statistics 23.ResultsFive consecutive cases with complex peripatellar defects (5 × 8 to 8 × 10 cm) were recruited. Two were males, and three were females, with a mean age of 38.4 years. Four were trauma, and one was an oncological case. Descending genicular artery (DGA) perforators and DGA terminal branches were consistent. One patient needed a split‐thickness skin graft to reconstruct the secondary defects. All the flaps survived with an average follow‐up of 24 months.ConclusionThe DGAP flap provides a reliable alternative to free flap for the large, complex peripatellar defect. With the inclusion of the proximal long saphenous vein and judicious selection of DGA perforators and its terminal branches, the DGAP flap can be harvested and used safely in the high‐velocity impacted knee.
Parents who spent more hours in intensive care units with their low birthweight newborn infant did not achieve autonomous care faster
Authors: Piris‐Borregas Salvador , Bellón‐Vaquerizo Beatriz , Muñoz‐López Olga , Cuadrado‐Obregón Natalia , Melchor‐Muñoz Patricia , Niño‐Díaz Lidia , González‐Mora Francisco Javier , Barroso‐Santiago María , Martín‐Arriscado Cristina , Pallás‐Alonso Carmen Rosa 
Published: June 2023

AbstractAimWe examined the correlation between how long it took the parents of very low birthweight infants, born weighing up to 1500 g, to provide different kinds of autonomous care in a neonatal intensive care unit (NICU).MethodsThis prospective observational was conducted in the NICU of a Spanish hospital from 10 January 2020 to 3 May 2022. The unit had 11 beds single‐family rooms and provided eight beds in an open bay room. The study examined breastfeeding, patient safety, participation in rounds, pain prevention and cleanliness.ResultsWe studied 96 patients and their parents and there was no correlation between any type of care and the time it took parents to provide it autonomously. Parents in the single‐family room cohort spent a median of 9.5 h per day between them in the NICU, while the parents in the open bay room spent 7.0 h with their infants (p = 0.03). However, parents in the single‐family room group were able to recognise pain faster (p = 0.02).ConclusionParents in single‐family rooms spent more time in the NICU and recognised pain faster but did not achieve autonomous care faster than parents in the open bay group.
Long‐term clinical outcomes of aspirin‐exacerbated respiratory disease: Real‐world data from an adult asthma cohort
Authors: Lee Youngsoo , Kim Chungsoo , Lee Eunyoung , Lee Hyun Young , Woo Seong‐Dae , You Seng Chan , Park Rae Woong , Park Hae‐Sim 
Published: June 2023

AbstractBackgroundAspirin‐exacerbated respiratory disease (AERD) is a phenotype of severe asthma, but its disease course has not been well documented compared with that of aspirin‐tolerant asthma (ATA).ObjectivesThis study aimed to investigate the long‐term clinical outcomes between AERD and ATA.MethodsAERD patients were identified by the diagnostic code and positive bronchoprovocation test in a real‐world database. Longitudinal changes in lung function, blood eosinophil/neutrophil counts, and annual numbers of severe asthma exacerbations (AEx) were compared between the AERD and the ATA groups. Within a year after baseline, two or more severe AEx events indicated severe AERD, whereas less than two AEx events indicated nonsevere AERD.ResultsAmong asthmatics, 353 had AERD in which 166 and 187 patients had severe and nonsevere AERD, respectively, and 717 had ATA. AERD patients had significantly lower FEV1%, higher blood neutrophil counts, and higher sputum eosinophils (%) (all p < .05) as well as higher levels of urinary LTE4 and serum periostin, and lower levels of serum myeloperoxidase and surfactant protein D (all p < .01) than those with ATA. In a 10‐year follow‐up, the severe AERD group maintained lower FEV1% with more severe AEs than the nonsevere AERD group.Conclusion and Clinical RelevanceWe demonstrated that AERD patients presented poorer long‐term clinical outcomes than ATA patients in real‐world data analyses.