bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intelligent Sonocatalytic Nanoagents for Energy Conversion‐Based Therapies
Authors: Feng Ziyan , Xiang Xi , Huang Jianbo , Wang Liyun , Zhu Bihui , Zhou Hongju , Pang Houqing , Cheng Chong , Ma Lang , Qiu Li 
Published: August 2023

AbstractSonodynamic therapy (SDT) utilizes ultrasound‐irradiating sonosensitizers to convert ultrasonic vibrations into chemical energy and produce reactive oxygen species (ROS) that cause cell apoptosis or necrosis. SDT demonstrates significant potential in the treatment of deep tumors without normal tissue damage. Rapid advances in the efficacy of SDT have enabled the rational design and construction of novel intelligent sonocatalytic nanoagents (SCNs) with various functions for versatile biomedical applications. Herein, the most recent critical advancements in intelligent SCNs for energy conversion‐based therapies are discussed. Typical SCNs including organic molecules, organic micro‐/nanoparticles, inorganic micro‐/nanoparticles, organic/inorganic hybrids, and piezoelectric materials are introduced and summarized in detail. Furthermore, these intelligent SCNs are designed for different energy conversion‐based therapies such as SDT, SDT‐assisted chemotherapy, SDT‐assisted photodynamic therapy, SDT‐assisted photothermal therapy, SDT‐assisted gas therapy, SDT‐assisted sonoporation from the cell membrane to the blood brain barrier, and high‐intensity focused ultrasound‐based sonothermal therapy. It is believed that this review will provide an overview of the application of intelligent SCNs in sonodynamic therapies to better understand the limitations and challenges of these SCNs and further promote their advancements for a broad range of biomedical applications.
The Impact of Digitalized Data Management on Materials Systems Workflows
Authors: Tristram Frank , Jung Nicole , Hodapp Patrick , Schröder Rasmus R. , Wöll Christof , Bräse Stefan 
Published: August 2023

AbstractThe basic modules for materials research are systems for the design, synthesis, preparation, analysis, and application of materials and materials systems. To be efficient and produce findable, accessible, interoperable, and reusable (FAIR) data, state‐of‐the‐art materials research needs to consider the integration of research data management (RDM) workflows and, in the end, the implementation of process automation concepts for all parts of the main modules. Here, the state‐of‐the‐art methods of RDM in academia are described and a perspective on the future of digitalized molecular material systems workflows is given. The different elements of an integrated research data management strategy are described, and examples of automated processes are depicted. As such, the use of electronic lab notebooks for comprehensive documentation, the use of data‐integration and data‐conversion strategies, and the establishment of two platforms that enable the automated synthesis of chemical components for materials and the analysis of materials by electron microscopy, are highlighted. Two examples of beneficial effects of successful RDM strategies are presented, showing a sophisticated tool for data prediction based on machine learning and options for creating community‐driven databases by extracting and re‐using data from different scientific projects.
On the Interplay between Size and Disorder in Suppressing Intercalation‐Induced Phase Transitions in Pseudocapacitive Nanostructured MoS2
Authors: Yao Yiyi , Cumberbatch Helen , Robertson Daniel D. , Chin Matthew A. , Lamkin Ryan , Tolbert Sarah H. 
Published: August 2023

AbstractPseudocapacitors are an emerging class of energy storage materials that offer an attractive compromise between the energy density of batteries and power density of electric double‐layer capacitors. Decreasing particle size and increasing surface area of battery materials is a common approach for introducing pseudocapacitive behavior and increasing power density. However, in many cases, as the crystal size is reduced, lattice disorder of unknown extent is also introduced, making it difficult to characterize the relative contribution of size and disorder to fast‐charging performance. In this work, a series of nanostructured MoS2 materials are synthesized with different crystallite sizes and degrees of crystallinity to decouple the effects of size and disorder on charge/discharge kinetics. The extent and type of disorder in each material is quantified by total X‐ray scattering experiments and pair distribution function analyses. Electrochemical characterization, including galvanostatic rate capability, cyclic voltammetry, and various kinetic analyses, are used to demonstrate that both decreasing particle size and introducing lattice disorder are effective strategies for increasing charge storage kinetics, and that the effects are additive. Finally, operando X‐ray diffraction measurements show that both size and disorder can be used suppress first‐order Li+ intercalation‐induced phase transitions, a key feature for enabling pseudocapacitive charge storage.
Microenvironment‐Responsive Hydrogels with Detachable Skin Adhesion and Mild‐Temperature Photothermal Property for Chronic Wound Healing
Authors: Geng Huimin , Zheng Xiaoyue , Zhang Yulin , Cui Xiaomiao , Li Zhiwei , Zhang Xunhui , Cui Jiwei , Meng Fangang , Sun Lei , Ni Shilei 
Published: August 2023

AbstractChronic wounds have emerged as a global healthcare burden that have inability to heal within an expected time frame owing to the complex pathophysiological microenvironment, bacterial infection, multidrug resistance, and fragile skin tissue. Tailored to the features of chronic wounds, a multifunctional hydrogel (GA) composed of ethylenediamine‐modified gelatin (Gela‐amino) and oxidized sodium alginate (Alg─CHO) is reported. The thermosensitivity of gelatin and Schiff base bonds endow GA hydrogels with physiological temperature‐enhanced nonirritating tissue adhesion and low‐temperature‐triggered nondestructive separation, beneficial for the management of vulnerable and sensitive wounds. In addition, GA hydrogels exhibit pH‐responsive degradation that adapt to the acidic wound microenvironment. Under near‐infrared (NIR) irradiation, DNase I enzyme and indocyanine green‐loaded GA hydrogels (DI@GA) efficiently eradicate drug‐resistant bacteria biofilm and subsequently exert an antibacterial effect attributed to the bioactity of GA hydrogels and mild‐temperature photothermal therapy (≈45 °C). Remarkably, DI@GA/NIR hydrogels accelerate diabetic wound recovery and skin regeneration by dispersing biofilm, killing bacteria, inhibiting inflammation, promoting collagen deposition, and improving angiogenesis. The advanced hydrogels without the addition of antibiotics are promising to act as skin‐friendly wound dressings for rescuing infectious and stalled chronic wounds.
Decellularized Scaffolds with Double‐Layer Aligned Microchannels Induce the Oriented Growth of Bladder Smooth Muscle Cells: Toward Urethral and Ureteral Reconstruction
Authors: Cheng Quhan , Zhang Linli , Zhang Jingai , Zhou Xin , Wu Boyu , Wang Dezheng , Wei Tingting , Shafiq Muhammad , Li Shengbin , Zhi Dengke , Guan Yong , Wang Kai , Kong Deling 
Published: August 2023

AbstractThere is a great clinical need for regenerating urinary tissue. Native urethras and ureters have bidirectional aligned smooth muscle cells (SMCs) layers, which plays a pivotal role in micturition and transporting urine and inhibiting reflux. Thus far, urinary scaffolds have not been designed to induce the native‐mimicking aligned arrangement of SMCs. In this study, a tubular decellularized extracellular matrix (dECM) with an intact internal layer and bidirectional aligned microchannels in the tubular wall, which is realized by the subcutaneous implantation of a template, followed by the removal of the template, and decellularization, is engineered. The dense and intact internal layer effectively increases the leakage pressure of the tubular dECM scaffolds. Rat‐derived dECM scaffolds with three different sizes of microchannels are fabricated by tailoring the fiber diameter of the templates. The rat‐derived dECM scaffolds exhibiting microchannels of ≈65 µm show suitable mechanical properties, good ability to induce the bidirectional alignment and growth of human bladder SMCs, and elevated higher functional protein expression in vitro. These data indicate that rat‐derived tubular dECM scaffolds manifesting double‐layer aligned microchannels may be promising candidates to induce the native‐mimicking regeneration of SMCs in urethra and ureter reconstruction.
Unraveling Synergistic Effect of Defects and Piezoelectric Field in Breakthrough Piezo‐Photocatalytic N2 Reduction
Authors: Yuan Jie , Feng Wenhui , Zhang Yongfan , Xiao Jianyu , Zhang Xiaoyan , Wu Yinting , Ni Wenkang , Huang Hongwei , Dai Wenxin 
Published: August 2023

AbstractPiezo‐photocatalysis is a frontier technology for converting mechanical and solar energies into crucial chemical substances and has emerged as a promising and sustainable strategy for N2 fixation. Here, for the first time, defects and piezoelectric field are synergized to achieve unprecedented piezo‐photocatalytic nitrogen reduction reaction (NRR) activity and their collaborative catalytic mechanism is unraveled over BaTiO3 with tunable oxygen vacancies (OVs). The introduced OVs change the local dipole state to strengthen the piezoelectric polarization of BaTiO3, resulting in a more efficient separation of photogenerated carrier. Ti3+ sites adjacent to OVs promote N2 chemisorption and activation through d–π back‐donation with the help of the unpaired d‐orbital electron. Furthermore, a piezoelectric polarization field could modulate the electronic structure of Ti3+ to facilitate the activation and dissociation of N2, thereby substantially reducing the reaction barrier of the rate‐limiting step. Benefitting from the synergistic reinforcement mechanism and optimized surface dynamics processes, an exceptional piezo‐photocatalytic NH3 evolution rate of 106.7 µmol g−1 h−1 is delivered by BaTiO3 with moderate OVs, far surpassing that of previously reported piezocatalysts/piezo‐photocatalysts. New perspectives are provided here for the rational design of an efficient piezo‐photocatalytic system for the NRR.
Intervertebral Disc‐on‐a‐ChipMF: A New Model for Mouse Disc Culture via Integrating Mechanical Loading and Dynamic Media Flow
Authors: Xie Wanqing , Xing Yuan , Xiao Li , Zhang Pu , Oh Richard , Zhang Yangpu , Yu Xiaoyu , He Yi , Oh Eunha G , Cao Ruofan , Ramasubramanian Melur K , Wang Yong , Jin Li , Oberhozler Jose , Li Xudong 
Published: August 2023

This study aims to develop an ex vivo organ‐on‐a‐chip model, intervertebral Disc‐on‐a‐ChipMF, to investigate integrated effects of mechanical loading and nutrition on disc health. The system consists of a detachable multilayer microfluidic chip, a Computer‐Arduino‐based control system, and a mechanical loading unit, which are optimized for accurate axial force measurement and the maintenance of a 21‐day ex vivo disc culture. To ensure accuracy of axial force, the axial mechanical loading regimen is optimized, using the Computer‐Arduino‐based system and low‐profile force sensors (LPFS) to control the mechanical loading unit, and the force distribution on the disc surface is modeled by computational simulation. A 21‐day ex vivo disc culture is demonstrated using the Disc‐on‐a‐ChipMF system, with optimized mechanical loading (0.02 MPa at 1Hz, 1.5 hr day−1) and flow rate (1 µL min−1). The structural integrity, collagen breakdown, catabolic enzyme activities, and disc cell and collagen alignment reveal that the on‐chip cultured discs exhibit a preferred disc health similar to that of native discs for up to 21 days, while discs in a static culture show degenerative changes. The mouse Disc‐on‐a‐ChipMF system mimics in vivo disc microenvironment and provides a valuable platform for studying the effects of various factors on disc health and degeneration and testing new therapies.
The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil Polarization And Ameliorates Immunopathology of Periodontitis
Authors: Song Jia , Zhang Yuning , Bai Yunyang , Sun Xiaowen , Lu Yanhui , Guo Yusi , He Ying , Gao Min , Chi Xiaopei , Heng Boon Chin , Zhang Xin , Li Wenjing , Xu Mingming , Wei Yan , You Fuping , Zhang Xuehui , Lu Dan , Deng Xuliang 
Published: August 2023

AbstractTissue‐infiltrating neutrophils (TINs) secrete various signaling molecules to establish paracrine communication within the inflammatory milieu. It is imperative to identify molecular mediators that control this secretory phenotype of TINs. The present study uncovers a secretory neutrophil subset that exhibits increased pro‐inflammatory cytokine production and enhanced migratory capacity which is highly related with periodontal pathogenesis. Further analysis identifies the OTU domain‐containing protein 1 (OTUD1) plays a regulatory role in this secretory neutrophil polarization. In human and mouse periodontitis, the waning of inflammation is correlated with OTUD1 upregulation, whereas severe periodontitis is induced when neutrophil‐intrinsic OTUD1 is depleted. Mechanistically, OTUD1 interacts with SEC23B, a component of the coat protein II complex (COPII). By removing the K63‐linked polyubiquitin chains on SEC23B Lysine 81, the deubiquitinase OTUD1 negatively regulates the COPII secretory machinery and limits protein ER‐to‐Golgi trafficking, thus restricting the surface expression of integrin‐regulated proteins, CD9 and CD47. Accordingly, blockade of protein transport by Brefeldin A (BFA) curbs recruitment of Otud1‐deficient TINs and attenuates inflammation‐induced alveolar bone destruction. The results thus identify OTUD1 signaling as a negative feedback loop that limits the polarization of neutrophils with secretory phenotype and highlight the potential application of BFA in the treatment of periodontal inflammation.
Rainbow‐Colored Carbon Nanotubes via Rational Surface Engineering for Smart Visualized Sensors
Authors: Zhang Jing , Tang Xueqing , Wei Jie , Cong Shan , Zhu Siqi , Li Yaowu , Yao Jian , Lyu Weibang , Jin Hehua , Zhao Meng , Zhao Zhigang , Li Qingwen 
Published: August 2023

AbstractSurface engineering is effective for developing materials with novel properties, multifunctionality, and smart features that can enable their use in emerging applications. However, surface engineering of carbon nanotubes (CNTs) to add color properties and functionalities has not been well established. Herein, a new surface engineering strategy is developed to achieve rainbow‐colored CNTs with high chroma, high brightness, and strong color travel for visual hydrogen sensing. This approach involved constructing a bilayer structure of W and WO3 on CNTs (CNT/W/WO3) and a trilayer structure of W, WO3, and Pd on CNTs (CNT/W/WO3/Pd) with tunable thicknesses. The resulting CNT/W/WO3 composite film exhibits a wide range of visible colors, including yellow, orange, magenta, violet, blue, cyan, and green, owing to strong thin‐film interference. This coloring method outperforms other structural coloring methods in both brightness and chroma. The smart CNT/W/WO3/Pd films with porous characteristics quickly and precisely detect the hydrogen leakage site. Furthermore, the smart CNT/W/WO3/Pd films allow a concentration as low as 0.6% H2/air to be detected by the naked eye in 58 s, offering a very practical and safe approach for the detection and localization of leaks in onboard hydrogen tanks.
Odd and Even Numbered Ferric Wheels
Authors: Cutler Daniel J. , Canaj Angelos B. , Singh Mukesh K. , Nichol Gary S. , Gracia David , Nojiri Hiroyuki , Evangelisti Marco , Schnack Jürgen , Brechin Euan K. 
Published: August 2023

AbstractThe structurally related odd and even numbered wheels [FeIII11ZnII4(tea)10(teaH)1(OMe)Cl8] (1) and [FeIII12ZnII4(tea)12Cl8] (2) can be synthesized under ambient conditions by reacting FeIII and ZnII salts with triethanolamine (teaH3), the change in nuclearity being dictated by the solvents employed. An antiferromagnetic exchange between nearest neighbors, J = ‐10.0 cm−1 for 1 and J = −12.0 cm−1 for 2, leads to a frustrated S = 1/2 ground state in the former and an S = 0 ground state in the latter.
Strain‐Induced Toroidal Polar States in Wrinkled Ferroelectric Polymer by Phase‐Field Simulations
Authors: Guo Changqing , Dong Shouzhe , Wang Jing , Wang Xueyun , Huang Houbing 
Published: August 2023

AbstractWrinkled ferroelectric polymer films with out‐of‐plane deformation exhibit exotic strain fields that differ from those of conventional epitaxial film systems, offering a new path toward manipulating electrical and mechanical behaviors in ferroelectrics. However, the direct observation of the domain structure evolution in ferroelectric polymer films during continuous deformation is challenging with current experimental approaches. In this study, the strain‐induced evolution of toroidal domain structures in organic poly(vinylidene fluoride‐ran‐trifluoroethylene) (P(VDF‐TrFE)) films with concentric toroidal wrinkle patterns is comprehensively investigated using phase‐field simulations. The results reveal morphology‐ and thickness‐dependent toroidal polar topology in wrinkled P(VDF‐TrFE) films. External strain loading can modulate this ferroelectric domain, which exhibits robust coupling behavior with a mixed strain field of periodic tensile and compressive strains. It is demonstrated that toroidal wrinkled ferroelectric films provide an effective and unique flexible platform for continuously controllable strain engineering in ferroelectrics and a theoretical framework with potential applications in flexible electronic devices.
Designing Soft Solid‐like Viscoelastic Zinc Powder Anode toward High‐Performance Aqueous Zinc‐Ion Batteries
Authors: Cao Chuheng , Zhou Keqin , Du Wencheng , Li Cheng Chao , Ye Minghui , Zhang Yufei , Tang Yongchao , Liu Xiaoqing 
Published: August 2023

AbstractZn powder is considered as a potential Zn metal anode for aqueous Zn‐ion batteries. However, restricted ion/electron transfer and volume effect‐caused electrical contact failure in conventional polymer binder composited Zn powder anodes deteriorate their electrochemical performance. Here, a high‐performance soft solid‐like viscoelastic Zn powder composite anode is proposed based on an oligomer gluing strategy. Benefiting from the viscoelastic properties, the soft‐solid Zn powder composite (ss‐ZnP) anode has significantly enhanced charge transfer, alleviated volume effect, and homogenized interfacial electric field, leading to fast plating/stripping kinetics and dendrite‐free deposition morphology. Furthermore, the assembled NH4V4O10‖ss‐ZnP full cell delivers higher capacity (510 mAh g−1 at 0.1A g−1, 300 mAh g−1 at 1A g−1) and longer lifespan up to 500 cycles at 1 A g−1, superior to conventional polymer binder composited Zn powder anode and other reported rheological Zn powder‐based anodes. Apart from the electrochemical merits, this soft matter‐based design also endows the ss‐ZnP electrode with free‐standing and malleable properties which greatly expand its practical application.
Plasma phosphorylated tau‐217 exhibits sex‐specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults
Authors: Saloner Rowan , VandeVrede Lawren , Asken Breton M. , Paolillo Emily W. , Gontrum Eva Q. , Wolf Amy , Lario‐Lago Argentina , Milà‐Alomà Marta , Triana‐Baltzer Gallen , Kolb Hartmuth C. , Dubal Dena B. , Rabinovici Gil D. , Miller Bruce L. , Boxer Adam L. , Casaletto Kaitlin B. , Kramer Joel H. 
Published: August 2023

AbstractINTRODUCTIONAccumulating evidence indicates disproportionate tau burden and tau‐related clinical progression in females. However, sex differences in plasma phosphorylated tau (p‐tau)217 prediction of subclinical cognitive and brain changes are unknown.METHODSWe measured baseline plasma p‐tau217, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) in 163 participants (85 cognitively unimpaired [CU], 78 mild cognitive impairment [MCI]). In CU, linear mixed effects models examined sex differences in plasma biomarker prediction of longitudinal domain‐specific cognitive decline and brain atrophy. Cognitive models were repeated in MCI.RESULTSIn CU females, baseline plasma p‐tau217 predicted verbal memory and medial temporal lobe trajectories such that trajectories significantly declined once p‐tau217 concentrations surpassed 0.053 pg/ml, a threshold that corresponded to early levels of cortical amyloid aggregation in secondary amyloid positron emission tomography analyses. CU males exhibited similar rates of cognitive decline and brain atrophy, but these trajectories were not dependent on plasma p‐tau217. Plasma GFAP and NfL exhibited similar female‐specific prediction of medial temporal lobe atrophy in CU. Plasma p‐tau217 exhibited comparable prediction of cognitive decline across sex in MCI.DISCUSSIONPlasma p‐tau217 may capture earlier Alzheimer's disease (AD)‐related cognitive and brain atrophy hallmarks in females compared to males, possibly reflective of increased susceptibility to AD pathophysiology.
Enhanced Electrocatalytic Water Oxidation by Interfacial Phase Transition and Photothermal Effect in Multiply Heterostructured Co9S8/Co3S4/Cu2S Nanohybrids
Authors: Chang Yanan , Ma Zhangyu , Lu Xuyun , Wang Shasha , Bao Jianchun , Liu Ying , Ma Chao 
Published: August 2023

AbstractThe rational design of advanced nanohybrids (NHs) with optimized interface electronic environment and rapid reaction kinetics is pivotal to electrocatalytic schedule. Herein, we developed a multiple heterogeneous Co9S8/Co3S4/Cu2S nanoparticle in which Co3S4 germinates between Co9S8 and Cu2S. Using high‐angle annular‐dark‐field imaging and theoretical calculation, it was found that the integration of Co9S8 and Cu2S tends to trigger the interface phase transition of Co9S8, leading to Co3S4 interlayer due to the low formation energy of Co3S4/Cu2S (−7.61 eV) than Co9S8/Cu2S (−5.86 eV). Such phase transition not only lowers the energy barrier of oxygen evolution reaction (OER, from 0.335 eV to 0.297 eV), but also increases charge carrier density (from 7.76×1014 to 2.09×1015 cm−3), and creates more active sites. Compared to Co9S8 and Cu2S, the Co9S8/Co3S4/Cu2S NHs also demonstrate notable photothermal effect that can heat the catalyst locally, offset the endothermic enthalpy change of OER, and promote carrier migrate, reaction intermediates adsorption/deprotonation to improve reaction kinetics. Profiting from these favorable factors, the Co9S8/Co3S4/Cu2S catalyst only requires an OER overpotential of 181 mV and overall water splitting cell voltage of 1.43 V to driven 10 mA cm−2 under the irradiation of near‐infrared light, outperforming those without light irradiation and many reported Co‐based catalysts.
Repurposing Iron‐ and 2‐Oxoglutarate‐Dependent Oxygenases to Catalyze Olefin Hydration
Authors: Wang Bingnan , Lu Yong , Cha Lide , Chen Tzu‐Yu , Palacios Philip M. , Li Liping , Guo Yisong , Chang Wei‐chen , Chen Chuo 
Published: August 2023

AbstractMononuclear nonheme iron(II) and 2‐oxoglutarate (Fe/2OG)‐dependent oxygenases and halogenases are known to catalyze a diverse set of oxidative reactions, including hydroxylation, halogenation, epoxidation, and desaturation in primary metabolism and natural product maturation. However, their use in abiotic transformations has mainly been limited to C−H oxidation. Herein, we show that various enzymes of this family, when reconstituted with Fe(II) or Fe(III), can catalyze Mukaiyama hydration—a redox neutral transformation. Distinct from the native reactions of the Fe/2OG enzymes, wherein oxygen atom transfer (OAT) catalyzed by an iron‐oxo species is involved, this nonnative transformation proceeds through a hydrogen atom transfer (HAT) pathway in a 2OG‐independent manner. Additionally, in contrast to conventional inorganic catalysts, wherein a dinuclear iron species is responsible for HAT, the Fe/2OG enzymes exploit a mononuclear iron center to support this reaction. Collectively, our work demonstrates that Fe/2OG enzymes have utility in catalysis beyond the current scope of catalytic oxidation.