bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alignment and specificities of Brazilian health agencies with international premises for the implementation of digital health in Primary Health Care: a rhetorical analysis
Authors: de Araújo Aguinaldo José , Silva Ísis de Siqueira , de Figueirêdo Renan Cabral , Lopes Rayssa Horácio , Silva Cícera Renata Diniz Vieira , Junior Osvaldo de Goes Bay , Lester Richard T. , Uchôa Severina Alice da Costa 
Published: July 2023

Abstract

Objective
To analyze the alignment of the arguments of Brazilian and international organizations for the adoption of digital health in Primary Health Care (PHC), from COVID-19.
Methods
This qualitative document analysis used a rhetorical analysis according to Perelman and Obrecht’s-Tyteca. Two independent researchers searched documents on the websites of the World Health Organization (WHO), the Pan-American Health Organization (PAHO), and the Brazilian Ministry of Health, Federal Council of Medicine, and Federal Council of Nursing between December 2021 and June 2022. The search terms were “digital health”, “telehealth”, “telemedicine”, “e-health”, “telessaúde”, “teleenfermagem”, “telemedicina", and “saúde digital”. Twenty official documents (recommendations, informative pages, guidelines, resolutions, laws, and ordinances) were identified, considering context, authorship, authenticity, reliability, nature, and key concepts.
Results
The international and Brazilian arguments emphasize the applicability of Information and Communication Technologies (ICTs) in health. In logical arguments based on the structure of reality, international bodies emphasize the overlap between health needs and the conditions for the applicability of ICTs, but in Brazil, there was a need to regulate the digital practices of these health professionals. In the structuring of the real, the international discourse contains illustrations of the relationship between the context of the health crisis caused by the COVID-19 pandemic and the concrete conditions for the applicability of digital health, while in Brazil the need to strengthen an environment conducive to the digital health policy.
Conclusions
The Brazilian alignment with international premises is evident, however, there is a need to strengthen the inclusion of digital health in the PHC policy in a socially and economically sustainable way.
Factors that influence esophageal dilation in achalasia
Authors: Sánchez-Terán Alfonso , Naranjo-Pardo Catalina , Varela-Barraza Omar , Prado-Salcedo Tatiana , Macías-Grajeda Michelle 
Published: July 2023

Abstract
Megaesophagus is defined by esophageal diameter >6 cm and changes such as tortuosity and angulation. Timed barium swallow (TBS) is the best study to identify these changes. Megaesophagus occurs in the natural course of the disease, and patients without adequate treatment can develop progressive esophageal dilation but the factors that might contribute to the development of megaesophagus remain unknown. A retrospective study with a total of 110 patients diagnosed with achalasia and without any previous esophageal surgery. There were no significant differences between the megaesophagus (n=85) and non-megaesophagus (n=25) groups regarding age (40.4 vs. 40.9 yrs., p=0.87), gender (63% vs. 44% females, p=0.08), baseline weight (72.9 vs. 77.8 kg, p=0.20), EAT (30 vs 26.9, p=0.14), ECKARDT (9.2 vs 8.1, p=0.10), and GERD scores (23.4 vs. 24.8, p=0.62). However, there were significant differences between the group of esophageal dilation <6 cm and megaesophagus regarding symptom duration (23.2 vs 35.5 months, p=0.03), weight loss (13.7 vs. 9.7 kg, p=0.05), preoperative weight (59.2 vs. 68.1 kg, p=0.0058), dysphagia score (2.7 vs. 2.4, p=0.004), and baseline esophageal length (22.8 vs. 25.6 cm, p<0.0001). 16% of patients with megaesophagus had a duration of symptoms of only 12 months. In conclusion, patients with megaesophagus lost less weight in comparison to the <6 cm group. We found that patients with megaesophagus had a longer symptom duration. However, the symptom duration was not proportionally related to the degree of esophageal dilation. Furthermore, neither the degree of dysphagia nor weight loss positively correlated with the degree of esophageal dilation.
Aqeuous humor cytokines concentration changes in patients with diabetic macular edema after intravitreal pharmacotherapy
Authors: Fursova A. Zh. , Derbeneva A. S. , Amir I. M. , Kozhevnikova O. S. , Telegina D. V. , Devyatkin V. A. 
Published: July 2023

Purpose: to analyze intraocular fluid (IOF) cytokine concentrations in patients with diabetic macular edema (DME) after intravitreal therapy with angiogenesis inhibitors or corticosteroids (CS).Materials and methods. 44 patients (45 eyes) were divided in 2 groups depending on the therapy: group 1 (n = 19) received an angiogenesis inhibitor (aflibercept) while group2 (n = 26) received CS (dexamethasone implant). They were tested for IOF cytokine levels by Milliplex® Map Human Cytokine/Chemokine Panel at treatment start and 3 months after either 3 monthly injections of aflibercept or a single dexamethasone implant injection.Results. The concentrations of ten cytokines (IL-8/CXCL8, IP-10/CXCL10, MCP-1/CCL2, PDGF-AA, GROα/CXCL1, VEGF-A, MIP-1β/CCL4, IL-15, IL-7, IL-6) were found to fall significantly in both groups of therapy. IL-6 and IL-5 levels showed the most significant drop as compared to other cytokines, with a more pronounced decrease in the aflibercept treatment group. In both groups, VEGF-A concentration showed a significant drop, and the share of the eyes that responded to the treatment was 94.7 % in the aflibercept therapy group and 96.2 % in in the dexamethasone implant group.Conclusion. The IOF concentration assessment of a number of pro-inflammatory cytokines/chemokines shows that both the anti-VEGF agent — aflibercept and CS — dexamethasone implant contribute to a decrease of inflammation which is observed 3 months after the start of treatment.
Using artificial neural networks for early diagnosis of glaucoma
Authors: Komarovskikh E. N. , Podtynnykh E. V. 
Published: July 2023

Purpose: to summarize the experience of the development and application of artificial neural networks (ANW) in early diagnosis of primary open-angle glaucoma (POAG).Material and methods. A total of 690 patients (918 eyes) were tested. The training clinical group consisted of 459 clinical examples (459 eyes), of which 369 eyes had an initial stage of POAG and 90 eyes had no glaucoma. The testing clinical group was represented by 131 examples (131 eyes), of which 110 eyes belonged to patients with POAG and 21 eyes were without glaucoma. The final diagnostic testing using ANW was conducted on 328 eyes with the diagnosis unknown to the researchers, which belonged to people with suspected POAG. The diagnostic complex included an optimally necessary set of research techniques.Results. ANW identified glaucoma in 198 eyes out of those with suspected glaucoma (60.4 %) with 100 % certainty. 76 eyes (23.2 %) were classified as non-glaucoma, or “healthy”; 54 eyes of the suspected glaucoma patients were identified as “doubtful”, whereupon they were retested by a neural network pool consisting of 5 neural networks. According to the results of the retesting, 28 eyes, or 51.9 % of the “doubtful” ones were identified as having glaucoma, whereas 26 eyes (48.1 %) were identified as non-glaucomatous, i. e. healthy.Conclusion. Our experience suggests that artificial neural networks pose no danger to the doctor or the patient and can be viewed as a very convenient tool for early POAG diagnostics.
A Review of the Physiological Role of Hypocretin in the Ventral
Tegmental Area in Reward and Drug Dependence
Authors: Kourosh-Arami Masoumeh , Komaki Alireza , Gholami Masoumeh 
Published: July 2023

Abstract:
Orexin (OX, hypocretin: HCRT) as a neuropeptide is produced in a distinct population
of neurons in the posterior lateral hypothalamus (LH). OX neurons implicate in reward function.
OX makes a main input from the hypothalamus to the ventral tegmental area (VTA) of the midbrain.
OX, through OX receptors (OXR1, OXR2) activates VTA dopamine (DA) neurons. VTA neurons
are involved in reward processing and motivation. In this review, we will discuss the OX effect
on addiction through VTA activation and related areas of the brain.
Design and Diversity Analysis of Chemical Libraries in Drug Discovery
Authors: Olmedo Dionisio A. , Durant-Archibold Armando A. , López-Pérez José Luis , Medina-Franco José Luis 
Published: July 2023

Abstract:
Chemical libraries and compound data sets are among the main inputs to start the drug
discovery process at universities, research institutes, and the pharmaceutical industry. The
approach used in the design of compound libraries, the chemical information they possess, and the
representation of structures, play a fundamental role in the development of studies: chemoinformatics,
food informatics, in silico pharmacokinetics, computational toxicology, bioinformatics, and
molecular modeling to generate computational hits that will continue the optimization process of
drug candidates. The prospects for growth in drug discovery and development processes in chemical,
biotechnological, and pharmaceutical companies began a few years ago by integrating computational
tools with artificial intelligence methodologies. It is anticipated that it will increase the
number of drugs approved by regulatory agencies shortly.
One High Voltage Regulation Method and Related Control Strategy in the
DC Transmission System
Authors: Ji Li , ZhenYu Guo , Xue You Zhang , Dao Jun Huang 
Published: July 2023

Background:
With the development of power transmission system, the problem of small
transmission capacity and low power quality of traditional AC power distribution methods is becoming
increasingly prominent. The DC power distribution method promotes its own rapid development
because of its suitability of connection between distributed generation and grid, high power
quality, large power supply capacity, low line cost and high reliability.

Objective:
In order to improve the transient performance when the system power fluctuates, a control
method that can perform voltage regulation to the DC system is designed in the process of calculating
the power command value of each converter station at the system level control. Simulation
results show that the designed control method can effectively improve the inertial characteristics and
transient response of DC transmission system.

Methods:
Aiming at the shortcomings of slow response speed and poor stability when the traditional
dual closed-loop PI controller is used as a converter level controller, a sliding mode controller is
designed. Simulation results show that the designed sliding mode controller can improve transient
characteristics of voltage regulation.

Results:
Voltage control strategy of the DC transmission network based on the converter station is
verified.

Conclusion:
A voltage control strategy based on distributed generation and secondary load switching
is designed. The simulation verifies the effectiveness of the designed control strategy.
Molecular Docking and Dynamics Simulation for Searching Anti-Cancer Compounds of Piperlongumine Derivatives that Have Potential as an Inhibitor Against MAO-B (Monoamine Oxidase B)
Authors: Suwardi Suwardi , Salim Agus , Nugrahani Raden Rara Fadhila Kirana , Amalia Yolanda 
Published: July 2023

The docking of the piperlongumine molecule and its derivatives has been carried out to find molecules that have the potential as anti-cancer. A total of 18 ligands were docked to the 2v5z protein using the autodock4 and autodock vina programs. The binding energies of piperlongumine and piperlongumine derivatives [R1 = CH3 and R2 = H] were -8.6 kcal/mol and -9.3 kcal/mol, respectively. Based on molecular dynamics simulations, the hydrogen bond interaction fraction was dominated by GLN 206 residue in both the SAG (88%) and piperlongumine derivatives ((R1=CH3, R2 = H)(93%) ligand, for this reason, this piperlongumine derivative molecule is predicted to have potential as MAO B inhibitor.
The problem of the influence of wartime stress on the condition of patients with mental and behavioral disorders
Authors: Bobyk O. A. 
Published: July 2023

Objective: to assess the impact of various wartime stresses on the condition of patients with mental illnesses, followed by the development of preventive measures. Materials and methods: a questionnaire and a survey of 510 patients with mental and behavioral disorders were conducted on voluntary terms. Then the subjects were divided into 2 groups: 1 group — those who were in the zone of direct combat operations; 2 group — those who were in safer zones. The calculation of the proportion of persons depending on the appropriate answers to questions, a comparison of the levels of anxiety and anxiety in connection with the military situation in patients of groups 1 and 2, as well as an analysis of the corresponding 510 outpatient charts studied in order to assess the impact of wartime stress on the nature of the course of mental illness. Results: the negative impact of wartime stress on the course of mental disorders was established in the form of a worsening of the clinical picture of diseases, an increase in the number of exacerbations and resistance to therapy. Conclusion: according to the results of the study, preventive measures are recommended.
Prospective Association Between Video and Computer Game Use During Adolescence and Incidence of Metabolic Health Risks: Secondary Data Analysis
Authors: Lebby Stephanie R , Shyam Sangeetha , Ramadas Amutha , Bohm Andrew R , Hill Julia C , Fortuna Karen L , Zoltick Stephanie R 
Published: July 2023

Background
Video and computer games are popular activities, with 72% of adolescents aged 13 to 17 years reporting video game use on either a computer, game console, or portable device. Despite high levels of video and computer game use in adolescence, relatively little scientific literature exists examining the association and effects of video and computer games on adolescents.

Objective
The objective of this study was to examine the prevalence of video and computer game use among US adolescents and rates of positive screens for obesity, diabetes, high blood pressure (BP), and high cholesterol.

Methods
A secondary data analysis was conducted using the National Longitudinal Study of Adolescent to Adult Health (Add Health) data, including adolescents aged 12 to 19 years between 1994 and 2018.

Results
Respondents (n=4190) who played the most video and computer games had a significantly (P=.02) higher BMI and were more likely to self-report having at least one of the evaluated metabolic disorders: obesity (BMI >30 kg/m2), diabetes, high BP (BP >140/90), and high cholesterol (>240). With increased video or computer game use, there was a statistically significant increase in high BP rates in each quartile, with those with more frequent use also having higher rates of high BP. A similar trend was observed for diabetes, though the association did not reach statistical significance. No significant association was observed between video or computer game use and diagnoses of dyslipidemia, eating disorders, or depression.

Conclusions
Frequency of video and computer game use is associated with obesity, diabetes, high BP, and high cholesterol in adolescents aged 12 to 19 years. Adolescents who play the most video and computer games have a significantly higher BMI. They are more likely to have at least one of the evaluated metabolic disorders: diabetes, high BP, or high cholesterol. Public health interventions designed to target modifiable disease states through health promotion and self-management may support the health of adolescents aged 12 to 19 years. Video and computer games can integrate health promotion interventions in gameplay. This is an important area for future research as video and computer games are integrated into the lives of adolescents.
Es Krim Dengan Bahan Dasar Susu Kuda Liar
Authors: Bay Thomas Daniel Riwu , Febianti Febianti 
Published: July 2023

Es krim merupakan salah satu produk pastry yang sangat disukai semua kalangan baik anak-anak, remaja, maupun dewasa. Pada umumnya es krim terbuat dari susu sapi, dan kedelai namun dalam penelitian ini, peneliti tertarik untuk menggunakan susu kuda liar sebagai bahan dasar pembuatan Es krim. Peneliti menggunakan teknik analisis deskriptif kuantitatif untuk menganalisa data tes organoleptik dan biaya produksi yang akan dinilai oleh 15 panelis. Hasil dari penelitian ini dapat disimpulkan bahwa kualitas es krim berbahan dasar susu kuda liar mendapatkan respon dari segi rasa dengan kategori enak, dari segi aroma dengan kategori cukup harum, dari segi tekstur dengan kategori lembut, dari segi warna dengan kategori cukup menarik. Untuk biaya yang dibutuhkan dalam pembuatan es krim berbahan dasar susu kuda liar sebanyak 1 resep yang dihitung dari dari fix cost dan variable cost adalah Rp.85.700 dengan harga jual untuk 1 cup adalah Rp. 5.713.

Ice cream is one of the most popular pastry products for all ages, both children, teenagers, and adults. In general, ice cream is made from cow's milk, and soy, but in this study, researchers are interested in using wild horse milk as the basic ingredient for making ice cream. Researchers used quantitative descriptive analysis techniques to analyze organoleptic test data and production costs which would be assessed by 15 panelists. The results of this study can be concluded that the quality of ice cream made from wild horse milk gets a response in terms of taste with a delicious category, in terms of aroma with a fairly fragrant category, in terms of texture with a soft category, in terms of color with a pretty attractive category. For the cost needed to make ice cream based on wild horse milk as much as 1 recipe which is calculated from the fixed cost and variable cost is Rp. 85,700 with the selling price for 1 cup is Rp. 5,713.
FAKTOR-FAKTOR YANG MEMPENGARUHI MINAT MAHASISWA IAIN SURAKARTA DALAM MEMILIH PERBANKAN SYARIAH
Authors: Fatimah Siti , Novitasari Maya , Muslimah Emy 
Published: July 2023

This study aims to determine whether there is a relationship between variables related to the results of student interest in choosing a islamic banking. The samples involved in the research were IAIN Surakarta students. Data were analyzed by using SPSS with multiple regression, so it can be known there is or no relation between independent variable with dependent variable. Independent variables in this study Includes gender, age, understanding law of usury, religious, social environment, and family. Meanwhile, for the dependent variable is student interest in choosing a islamic banking. Based on this study, the independent variables that significantly influence the dependent Â variables there is only one, namely the understanding of usury law.Â Keywords:Â independent variable; dependent variable; islamic bank; IAIN Surakarta
TINDAK TUTUR ILOKUSI DALAM LIRIK LAGU ALBUM MONOKROM KARYA MUHAMMAD TULUS RUSDY
Authors: Giyanti Giyanti , Nurcahyo Rizki Joko , Saputri Diah Iskafatmawati 
Published: July 2023

This study aims to describe the forms of illocutionary speech acts classification in the lyrics of the song Monochrome album by Muhammad Tulus Rusdi. Illocutionary speech acts have a communicative function between the speaker and the interlocutor, so it is through this speech act that it can be known the message contained in the song lyrics delivered by Muhammad sincerely Rusdi to music lovers. The data source in this study is the song lyrics in the Monochrome Album by Muhammad Tulus Rusdy which consists of 10 songs: Strong Man, Farewell, Space Alone, Soul Swap, Infatuation, Light, Sky Gray, Masterpiece, and Hurry. This research uses a theoretical approach, which is a pragmatic approach. The method used in this research is descriptive qualitative. The technique used in this study is refer to and note. The results of the study showed that there were 96 data included in the action of the ilocuis speech. Illocutionary speech acts include (1) assertive speech acts, namely: notifying, stating, complaining, demanding, and suggesting. (2) directive speech acts, namely: asking, pleading, advising, commanding. (3) declarative speech acts, namely: naming. (4) expressive speech acts, namely praising and thanking. (5) commissive speech acts, namely promises.Â Keywords: illocution; song lyrics; monochrome; speech act; sincere
THE ILLOCUTINOARY SPEECH ACTS OF HANUM (ACHA SEPTRIASA)â€™S UTTERANCES IN THE MOVIE â€˜BULAN TERBELAH DI LANGIT AMERIKAâ€™
Authors: Khasanah Tanti Nur , Rahmawati Fauziah Fatkhu 
Published: July 2023

This research is aimed to identify and analyze the illocutionary speech acts of Hanum (Acha Septriasa) found in the movie â€˜Bulan Terbelah di Langit Amerikaâ€™ (The Moon Was Separated on The Sky of America) based on Searleâ€™s theory. The approach of this research is qualitative by using content analysis method. The data are the illocutionary speech acts of Hanumâ€™s utterances in the movie â€˜Bulan Terbelah di Langit Amerikaâ€™. The data is collected by watching the movie. Researchers use the Miles and Huberman technique in analyzing the data. Searleâ€™s theory is essentially requisite for analyzing the utterances. The result of the analysis shows that the total classification of illocutionary speech acts in Hanumâ€™s utterances are 69. The 43% of the utterances are representatives, 28% are expressives, 23% are directives, and 3% are commisives and declaratives also has 3%.Â Keywords: Illocutionary speech acts; Hanumâ€™s utterances; â€˜Bulan Terbelah di Langit Amerikaâ€™; Searleâ€™s theory; Qualitative
Determinación de propiedades de baldosas de grano lavado, usando una mezcla de cemento, granito y caucho triturado en la capa de desgaste
Authors: Vanegas Useche, Libardo Vicente , Granada Mejía Miguel Ángel , Arbeláez Ríos Sergio Esteban , Arias Maya Luz Stella 
Published: July 2023

Las llantas fuera de uso constituyen un problema ambiental, ya que son visualmente contaminantes, atentan contra la salud pública y pueden ser generadoras de incendios. El propósito de este trabajo es evaluar la viabilidad técnica de incorporar el caucho proveniente de llantas fuera de uso como materia prima en la elaboración de la capa de desgaste de baldosas bicapa de grano lavado. Para la capa de desgaste compuesta de cemento gris y agregado (granito y caucho triturado), se diseñaron tres mezclas con sustitución de granito por caucho triturado en porcentajes de 0%, 30% y 50%. Se evaluaron propiedades físicas y mecánicas, usando como documento de referencia la norma NTC 2849: Baldosas con superficie de grano (terrazo). Los resultados demuestran que la resistencia al desgaste no se ve afectada ni favorecida por la adición de caucho y que la resistencia al impacto mejora conforme al aumento del porcentaje de granito sustituido por caucho. También, se encontró que la densidad disminuye y la absorción de agua aumenta con la incorporación de caucho. El estudio realizado indica que la incorporación de caucho triturado en la capa de desgaste de baldosas de grano lavado es viable y puede aportar a reducir la contaminación ambiental.