bluuebunny/crossref_metadata_2025_split huggingface dataset:
The work–life balance puzzle: a key to success in business and life
Authors: Nieto-Aleman Paula Andrea , Berné-Martínez José-Miguel , Arnal-Pastor Maria 
Published: January 2025

PurposeWork–life balance (WLB) is necessary to allow organisations to innovate and develop markets. WLB enables employee development and influences employee motivation and productivity by helping retain employees and keeping them engaged. The aim of this study is to identify the causal configurations leading to employees’ perceived WLB.Design/methodology/approachFuzzy set qualitative comparative analysis (fsQCA) is used to identify the causal patterns of necessary and sufficient conditions that lead to WLB. Two dimensions of WLB are considered: (1) context (socioeconomic level and distance to work) and (2) organisation (work flexibility, job security and teleworking). These dimensions are studied to determine whether they lead to WLB. The study focuses on the city of Vila-real (Spain). The study data are sourced from male and female parents aged 19–56 years.FindingsThere are gender differences in perceived WLB. The observation that no single strategy leads to WLB is especially true for women, who achieve WLB through nine combinations of factors. For men, having a full-time contract is conducive to WLB. In contrast, women’s perception towards teleworking affects their perceived WLB.Originality/valueThe framework developed in this paper can be used to identify necessary and sufficient pathways to WLB to support the development of WLB policies and practices. It provides managers and policymakers with a framework to promote employee-centred WLB policies and practices.
Impact of remittances from the Afghan diaspora: a case study on the effects in the Samangan province
Authors: Barlas Ahmad Walid , Elo Maria , Chand Masud 
Published: January 2025

PurposeThe study examines the relationship between international remittances and income inequality in Afghanistan by analysing how remittances affect income inequality in the Samangan province.Design/methodology/approachPrimary data were collected by administering a questionnaire to 325 households in the Samangan province using a multi-stage sampling approach. Income distribution was measured using the Gini coefficient.FindingsThere were an average of 8 members and 1.5 migrants in each household, with the mean age of respondents being 35. Remittances formed about 25% of the household income and had a slight negative effect on income inequality, with a 1% increase in remittances leading to a 0.04% decrease in inequality.Research limitations/implicationsThe data were collected in one province. The findings underline the need to develop policies that foster peace and stability through reducing inequality.Practical implicationsInternational remittances can form a significant portion of household income in conflict-affected and post-conflict societies. The effect of remittances on income distribution can help us understand where development efforts need to be channelled and how businesses can best operate in challenging circumstances.Originality/valueThis is the only study to our knowledge that looks at the effects of migration and remittances on income inequality in Afghanistan.
The Functional and Structural Succession of Mesic‐Grassland Soil Microbiomes Beneath Decomposing Large Herbivore Carcasses
Authors: Fouché Jacques , Lebre Pedro H. , Melville Haemish A. , Cowan Don A. 
Published: January 2025

ABSTRACTPlant detritus is abundant in grasslands but decomposes slowly and is relatively nutrient‐poor, whereas animal carcasses are labile and nutrient‐rich. Recent studies have demonstrated that labile nutrients from carcasses can significantly alter the long‐term soil microbial function at an ecosystem scale. However, there is a paucity of knowledge on the functional and structural response and temporal scale of soil microbiomes beneath large herbivore carcasses. This study compared microbiome functions and structures of soil beneath Connochaetes taurinus (hereafter ‘wildebeest’) carcasses at various postmortem intervals of decomposition to matched control samples over 18 months. Microbial functions were compared by their community‐level physiological profiles determined by sole‐carbon substrate utilisation and structures by metagenomic sequences using 16S rRNA gene markers. Overall metabolism and metabolic diversity remained increased and functionally dissimilar to control soils throughout the experimental period, with successive sole‐carbon substrate utilisation observed. Conversely, diversity was initially reduced and structurally dissimilar from the control soil but recovered within the experimental period. The study contributes to the knowledge of carcass decomposition by investigating the long‐term soil microbiome dynamics resulting from large herbivore carcasses decomposing in a mesic grassland. Microbial functional succession and ecologically relevant bacterial biomarkers of soil beneath the decomposing carcasses were identified for various postmortem intervals.
EPISTEMIC JUSTICE AND THE UNIVERSITY: Reclaiming the academy for emancipatory urban praxis
Authors: Butcher Stephanie , Shafique Tanzil , Recio Redento B. , Chatterjee Ishita 
Published: January 2025

AbstractThis essay offers provocations on the possibilities and challenges of advancing ‘epistemic justice’ in urban research, with particular care for the growing ‘academic precariat’. We explore some of the institutional barriers and possibilities of doing collaborative justice‐oriented work within urban and built environment scholarship, especially for those fixed‐term, early career, casual academics, independent scholars or those with career breaks. To do so, we refer to and reframe three concepts that are core within academic institutions: ethics, engagement and excellence. We explore the potentials of the urban as a site of political struggles, the projective potential of urban disciplines and the university as an urban actor to offer our intentionalities—alternative pathways—through which we can reclaim the radical role of the university towards an emancipatory urban praxis.
Chinese Registry of Rheumatoid Arthritis (CREDIT) VI: Temporal Trends in Patients With Early Rheumatoid Arthritis and Moderate‐To‐Severe Disease Activity ‐ A Multicenter Cohort Study of Treatment Strategies and Outcomes
Authors: Deng Yafang , Qiao Lin , Li Hongbin , Yu Chen , Jin Shangyi , Wang Jing , Zou Qinghua , Wu Lijun , duan Xinwang , Xu Jian , Mo Hanyou , Jiang Zhenyu , Jiang Nan , Wang Yanhong , Zeng Xiaofeng , Li Mengtao , Wang Qian , Tian Xinping ,   CREDIT Co‐authors
Published: January 2025

ABSTRACTAimThe continuous update of international guidelines and enhanced availability of biological disease‐modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) have made a significant impact on the diagnosis and treatment of early rheumatoid arthritis (ERA). This study aims to systematically evaluate the current treatment strategies and outcomes within a large‐scale cohort of patients with ERA.MethodsData from the Chinese Registry of Rheumatoid Arthritis (CREDIT), a large multicenter Chinese registry of RA, were collected to analyze temporal trends in clinical profiles, therapeutic strategies, and treatment outcomes among patients with ERA.ResultsFrom November 2016 to October 2023, A total of 2722 patients with follow‐up information for 6 months were included. The use of methotrexate (MTX) increased annually and has become the predominant DMARD as the initial treatment. Following initial therapy, 1059 (38.9%) patients achieved the therapeutic target of low disease activity and remission. Age ≥ 50 years (adjusted OR 0.70 [95% CI 0.59–0.83]; p < 0.001), high baseline disease activity (adjusted OR 0.48 [95% CI 0.41–0.57]; p < 0.001), csDMARD monotherapy other than MTX (adjusted OR 0.55 [95% CI 0.41–0.73]; p < 0.001), and the use of b/tsDMARDs without a csDMARD combination (adjusted OR 0.57 [95% CI 0.36–0.87]; p = 0.011) were associated with lower target attainment rates. For patients who did not achieve the treatment target after initial therapy, the use of b/tsDMARDs increased after 2020, although the extent of therapeutic escalation remained suboptimal.ConclusionTreatment of patients with ERA in China has become more standardized. Adherence to guideline‐directed therapeutic regimens has emerged as a significant determinant of therapeutic target achievement. The increased prevalence of b/tsDMARDs would benefit more patients in ameliorating the disease.
Body mass index trajectories from birth to adolescence and associated factors in the PARIS cohort
Authors: Lefebvre Léa , Nur Riem , Grunemwald Thomas , Hamrene Karima , Roda Céline , Momas Isabelle 
Published: January 2025

AbstractAimDevelopment of body mass index (BMI) trajectories is essential for understanding childhood overweight, a public health concern. This study aimed to identify BMI trajectories from birth to adolescence and examine associated factors in the Pollution and Asthma Risk: an Infant Study (PARIS) birth cohort.MethodsData on height, weight, birth parameters, lifestyle, parental weight status and stress were collected via questionnaires and health check‐ups. BMI z‐score (BMIz) trajectories were developed using group‐based trajectory modelling on anthropometric data collected at least six times. Associated factors were investigated in multivariable multinomial logistic regression models, adjusted for confounders.ResultsFive BMIz trajectories were identified in 540 adolescents. The early high stable BMI trajectory grouped participants who reached overweight status in early childhood. Four trajectories remained within the normal weight status: low stable BMI, continuous decrease BMI, continuous increase BMI, and early increase and slight decrease BMI trajectories. Compared with low stable BMI, high BMI trajectories were associated with higher parental weight status, early rebound age, excessive TV watching, lower food avoidance score, stressful events in early life and parent–child relationship stress.ConclusionHigh BMI trajectories shared several modifiable factors, emphasising the need for multifactorial interventions to tackle the childhood overweight epidemic.
Arrhythmogenic calmodulin variants D131E and Q135P disrupt interaction with the L‐type voltage‐gated Ca2+ channel (Cav1.2) and reduce Ca2+‐dependent inactivation
Authors: Gupta Nitika , Richards Ella M. B. , Morris Vanessa S. , Morris Rachael , Wadmore Kirsty , Held Marie , McCormick Liam , Prakash Ohm , Dart Caroline , Helassa Nordine 
Published: January 2025

AbstractAimLong QT syndrome (LQTS) and catecholaminergic polymorphism ventricular tachycardia (CPVT) are inherited cardiac disorders often caused by mutations in ion channels. These arrhythmia syndromes have recently been associated with calmodulin (CaM) variants. Here, we investigate the impact of the arrhythmogenic variants D131E and Q135P on CaM's structure–function relationship. Our study focuses on the L‐type calcium channel Cav1.2, a crucial component of the ventricular action potential and excitation–contraction coupling.MethodsWe used circular dichroism (CD), 1H‐15N HSQC NMR, and trypsin digestion to determine the structural and stability properties of CaM variants. The affinity of CaM for Ca2+ and interaction of Ca2+/CaM with Cav1.2 (IQ and NSCaTE domains) were investigated using intrinsic tyrosine fluorescence and isothermal titration calorimetry (ITC), respectively. The effect of CaM variants of Cav1.2 activity was determined using HEK293‐Cav1.2 cells (B'SYS) and whole‐cell patch‐clamp electrophysiology.ResultsUsing a combination of protein biophysics and structural biology, we show that the disease‐associated mutations D131E and Q135P mutations alter apo/CaM structure and stability. In the Ca2+‐bound state, D131E and Q135P exhibited reduced Ca2+ binding affinity, significant structural changes, and altered interaction with Cav1.2 domains (increased affinity for Cav1.2‐IQ and decreased affinity for Cav1.2‐NSCaTE). We show that the mutations dramatically impair Ca2+‐dependent inactivation (CDI) of Cav1.2, which would contribute to abnormal Ca2+ influx, leading to disrupted Ca2+ handling, characteristic of cardiac arrhythmia syndromes.ConclusionsThese findings provide insights into the molecular mechanisms behind arrhythmia caused by calmodulin mutations, contributing to our understanding of cardiac syndromes at a molecular and cellular level.
Network Meta‐Analysis: Comparison of Endoscopic Dysplasia Detection Technologies in Inflammatory Bowel Disease
Authors: Shehab Mohammad , Al‐Hindawi Ahmed , Alrashed Fatema , Murthy Sanjay , Bisschops Raf , Hoentjen Frank , Barkun Alan , Singh Siddharth , Bessissow Talat 
Published: January 2025

ABSTRACTBackgroundNovel colorectal cancer endoscopic surveillance techniques for inflammatory bowel disease (IBD) have recently been developed.AimsCompare the efficacy of currently available techniques for dysplasia detection in colonic IBD.MethodsWe conducted a systematic literature search from inception to March 2024 for randomized controlled trials (RCTs) or prospective cohort studies enrolling adults with IBD and having surveillance colonoscopy for dysplasia screening. Primary outcome was the number of dysplastic lesions (per‐lesion analysis). Secondary outcome was the number of patients with dysplasia (per‐patient analysis). We assessed endpoints using the frequentist NMA random effect model.ResultsWe included 25 studies (22 RCTs). 4837 patients met eligibility criteria (850 total dysplastic lesions; 105 with advanced dysplasia). Nine different screening techniques were studied. In per‐lesion analysis, dye‐based chromoendoscopy (DCE) ranked the highest (83%) per SUCRA ranking. DCE was superior to HD‐WLE (OR, 1.78; 95% CI, 1.06–3.00). There were no significant differences between NBI and DCE, HD‐WLE with SR or CEM in head‐to‐head comparisons. In a sub‐analysis confined to ulcerative colitis (UC), DCE ranked highest (98%) with per‐lesion analysis, and was superior to NBI (OR, 1.69; 95% CI, 1.03–2.77).ConclusionsHD‐WLE‐SR, DCE and CEM demonstrated superiority over other techniques for detection of dysplasia in colonic IBD. DCE was superior for dysplasia detection in colonic IBD. DCE was superior to HD‐WLE in colonic IBD. DCE was the best technique in UC. Further studies to compare HD‐WLE‐SR and NBI with DCE are warranted to ascertain performance equivalency and define the optimal surveillance technique.
“Fly to New World”: Meeting report of the 16th Japanese Drosophila research conference (JDRC16)
Authors: Yoshizawa Haruka , Kuranaga Erina 
Published: January 2025

AbstractThe 16th Japanese Drosophila Research Conference (JDRC16) was held at the Sendai International Center from September 17 to 19 2024. It had been 2 years since the last JDRC15 held in Nagoya. The conference brought together 231 researchers, including 22 researchers from overseas, creating a vibrant and diverse platform for scientific exchange. Prof. Shigeo Hayashi of RIKEN BDR delivered a keynote lecture, and his groundbreaking ideas and research captivated the audience. Over the 3 days, the conference featured 53 oral presentations across 11 sessions and 2 special sessions, as well as 128 poster presentations, all of which fostered stimulating discussions and the exchange of innovative ideas. The reception provided an additional opportunity for researchers to engage in meaningful dialogue while enjoying Sendai's renowned specialties. Held under clear autumn skies in a great nature along the river, this conference painted a beautiful contrast to the heated discussions in the venue. Consequently, this conference fully contributed to the mission proffered by Prof. Hayashi, “Fly to New World,” expanding the insights gained from flies into new and unexplored scientific areas.
Diabetes visits in paediatric versus adult clinics for young adults (YA) with T1D: Pre‐pandemic and pandemic care
Authors: Shapira Amit , Tinsley Liane J. , Toschi Elena , Laffel Lori M. 
Published: January 2025

AbstractBackgroundYoung adults (YA) with type 1 diabetes mellitus (T1D) are at high risk of worsening glycated haemoglobin (HbA1c) with fewer follow‐up visits. We examined the association of demographic and diabetes characteristics with care utilization, including in‐person and telehealth visits, pre‐ (1 April 2019 to 15 March 2020) and during the COVID‐19 pandemic (30 March 2020 to 15 March 2021) for YA (ages: 18–30) with T1D, comparing those seen in paediatric versus adult diabetes clinics at a single diabetes centre.MethodsData were obtained from the electronic health record for YA with a pre‐pandemic HbA1c. We performed descriptive statistics to describe the sample and paired t‐tests to compare visits before and during the pandemic.ResultsData from 1762 YA (54% male; age 24.0 ± 3.6 (M ± SD) years; HbA1c 66 ± 18 mmol/mol (8.2 ± 1.6%) revealed that in the full sample, mean pre‐pandemic visit frequency was 3.5 ± 3.4 and mean pandemic visit frequency was 3.1 ± 4.1 (p < 0.0001). Furthermore, the pandemic visit frequency declined in the adult clinic regardless of sex, pump therapy, CGM use, and pre‐pandemic HbA1c, whereas in the paediatric clinic, visit frequency was only reduced for those with HbA1c <53 mmol/mol (<7%) but was otherwise maintained.ConclusionsIn this diabetes centre, the paediatric clinic maintained diabetes care delivery during the pandemic (30 March 2020 to 15 March 2021) to YA with glycaemic control above target, suggesting that preservation of remote care delivery should be considered in this high‐risk group.
Educating We the People: Jean‐Luc Nancy and the Spirit of 1968
Authors: Arcilla René V. 
Published: January 2025

AbstractThis essay by René Arcilla examines Jean‐Luc Nancy's understanding of the “spirit of 1968.” It argues that Nancy's concept can guide a humanist approach to educating citizens for participation in democratic self‐government, one that responds to the political challenges facing us today. In particular, it develops a critique of factionalizing identity politics and seeks to renew what it means to address, and be addressed by, “we the people.” The essay proposes an idea of what democracy seeks to affirm: our social being.
Additive Effects of Multiple Global Change Factors on Plant Invasions Are Common
Authors: Shi Xiong , Liu Yanjie , van Kleunen Mark 
Published: January 2025

ABSTRACTQuantifying how co‐acting global change factors (GCFs) influence plant invasion is crucial for predicting future invasion dynamics. We did a meta‐analysis to assess pairwise effects of five GCFs (elevated CO2, drought, eutrophication, increased rainfall and warming) on native and alien plants. We found that alien plants, compared to native plants, suffered less or benefited more for four of the eight pairwise GCF combinations, and that all GCFs acted additively. Subgroup analysis showed that the relative benefits of alien over native plants were particularly apparent when they grew in competition with one another, and that the results were largely the same when the aliens were restricted to naturalised or invasive species. Our meta‐analysis provides evidence that additive effects of multiple global change factors on plant invasions are common, and thus that with the ongoing global environmental changes, the risk of plant invasion continues to increase.
Understanding Wealth‐Tax Rates: An Investor‐Utility Mapping to Capital‐Gains Taxes
Authors: Farago Adam , Hjalmarsson Erik , Kiss Tamás 
Published: January 2025

ABSTRACTWealth‐tax rates are formulated as fractions of a capital stock, rather than fractions of income from capital, which makes them difficult to compare with other (income‐based) tax rates. We derive investor‐utility comparisons between wealth‐tax rates and realized capital‐gains tax rates, capturing two crucial features absent in naive comparisons: Risk‐aversion and investment horizon, both of which magnify the effect of wealth taxes vis‐ à‐vis capital‐gains taxes. In numerical calibrations, we show that whereas a 1‐percent wealth tax might naively be judged equivalent to a 10% capital‐gains tax, a more accurate figure for a long‐run risk‐averse investor is 25%.
Management Measures and Trends of Biological Invasions in Europe: A Survey‐Based Assessment of Local Managers
Authors: Garcia‐Lozano Carla , Pueyo‐Ros Josep , Canelles Quim , Latombe Guillaume , Adriaens Tim , Bacher Sven , Cardoso Ana Cristina , Cleary Michelle , Coromina Lluís , Courchamp Franck , Dawson Wayne , de Groot Maarten , Essl Franz , Gallardo Belinda , Golivets Marina , Huusela Erja , Jauni Miia , Jelaska Sven D. , Jeschke Jonathan M. , Katsanevakis Stelios , Kourantidou Melina , Kühn Ingolf , Lenzner Bernd , Leung Brian , Marchante Elizabete , O'Flynn Colette , Pérez‐Granados Cristian , Pergl Jan , Pipek Pavel , Preda Cristina , Ribeiro Filipe , Roy Helen , Scalera Riccardo , von Schmalensee Menja , Seebens Hanno , Stefánsson Róbert A. , Tokarska‐Guzik Barbara , Tricarico Elena , Vanderhoeven Sonia , Vandvik Vigdis , Vilà Montserrat , Roura‐Pascual Núria 
Published: January 2025

ABSTRACTBiological invasions are a major threat to biodiversity, ecosystem functioning and nature's contributions to people worldwide. However, the effectiveness of invasive alien species (IAS) management measures and the progress toward achieving biodiversity targets remain uncertain due to limited and nonuniform data availability. Management success is usually assessed at a local level and documented in technical reports, often written in languages other than English, which makes such data notoriously difficult to collect at large geographic scales. Here we present the first European assessment of how managers perceive trends in IAS and the effectiveness of management measures to mitigate biological invasions. We developed a structured questionnaire translated into 18 languages and disseminated it to local and regional managers of IAS in Europe. We received responses from 1928 participants from 41 European countries, including 24 European Union (EU) Member States. Our results reveal substantial efforts in IAS monitoring and control, with invasive plants being the primary focus. Yet, there is a general perception of an increase in the numbers, occupied areas, and impacts of IAS across environment and taxonomic groups, particularly plants, over time. This perceived increase is consistent across both EU and non‐EU countries, with respondents from EU countries demonstrating more certainty in their responses. Our results also indicate a lack of data on alien vertebrates and invertebrates, reflecting a need for more targeted monitoring and knowledge sharing between managers and policymakers and between countries. Overall, our study suggests that Europe's current strategies are insufficient to substantially reduce IAS by 2030 and hence to meet the Kunming‐Montreal Global Biodiversity Framework target.