bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association between environmental noise exposure and primary headache in pediatric population
Authors: Lee Sunho , Lee Wanhyung 
Published: August 2023

Abstract

Background Headaches are the most common neurological symptom in pediatric patients. Most primary headaches in children and adolescents are associated with noise. Auditory discomfort is also associated with pain recognition. We aimed to analyze the headache profile of pediatric populations and the connection between noise exposure and headaches in children and adolescents. Methods We retrospectively reviewed the medical records of pediatric headache populations at Gyeongsang National University Changwon Hospital from January 2022 to April 2023. Environmental noise data from the National Noise Information System (NNIS) were used to analyze each variable, and chi-square tests and linear regression models were used to analyze statistical correlations. Results Of the 224 participants, 125 were clinically diagnosed with primary headaches. Both daytime and nighttime noise levels were significantly higher in the diagnosed headache group than in the non-diagnosed group. For daytime and nighttime noise, statistical significance was found for the severity, duration, and frequency of headaches. Headache duration increased with daytime and nighttime noise with statistical significance in the age-adjusted models. Conclusions Noise exposure was associated with headaches in children and adolescents. Our data showed that daytime and nighttime environmental noise exposure was significantly associated with headaches duration. Therefore, we assumed that noise exposure is a vital precipitant of headaches in the pediatric population. However, further research is required to validate our findings.
Southernmost record of an epibiotic alga Pseudocladophora conchopheria (Sakai) Boedeker &amp; Leliaert, 2012 (Cladophorales, Ulvophyceae) with the insights on the geographic genetic divergence and host shift
Authors: Kagawa Osamu , Tu Van , Hanyuda Takeaki , Chiba Satoshi , Yamazaki Daishi 
Published: August 2023

Abstract

Accumulating information on the distribution of symbionts and their host species is important for studying how the symbionts have diversified. Pseudocladophora conchopheria is a green alga that grows on the shells of specific intertidal gastropods distributed in the Japanese archipelago, Ryukyu islands and Southern part of the Korean Peninsula. We newly report southernmost record of Pseudocladophora conchopheria on the shells of the gastropod, Lunella granulata from Vietnam. Species identification of the alga and gastropod was based on morphological observations and molecular genetic methods. Interestingly, its haplotypes of P. conchopheria were closely related to the haplotypes of P. conchopheria attached to Lunella correensis from Sea of Japan, rather than the haplotype of P. conchopheria attached to L. granulata from the Ryukyu archipelago. Therefore, the results suggested host shift and geographic genetic differentiation. We highlight the overlooked biodiversity and biological interaction occurred in the molluscan shells and suggest that this new record is important for studying the relationship between P. conchopheria and the host gastropods.
Phytotoxicity Alleviation of Imazethapyr to Non-target Plant Wheat: Active Regulation Between Auxin and DIMBOA
Authors: Huang Jinye , Li Jun , Chen Hui , Shen Chensi , Wen Yuezhong 
Published: August 2023

Abstract
Effectively controlling target organisms while reducing the adverse effects of pesticides on non-target organisms is a crucial scientific inquiry and challenge in pesticide ecotoxicology research. Here, we studied the alleviation of herbicide (R)-imazethapyr ((R)-IM) to non-target plant wheat by active regulation between auxin and secondary metabolite 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazine-3(4H)-one (DIMBOA). (R)-IM effortlessly disrupted the balance between wheat growth and defense, which reduced 32.4% auxin content in wheat leaves and induced 40.7% DIMBOA accumulation compared to the control group. Transcriptomic results indicate that restoration of the auxin level in plants promotes the up-regulation of growth-related genes, and increased accumulation of DIMBOA increases the expression of defense-related genes. Auxin and DIMBOA are in two divergent paths and alleviate herbicide stress on wheat primarily through effects on growth and defense, respectively. Additionally, as a common precursor of auxin and DIMBOA, indole adopted a combined growth and defense strategy in response to (R)-IM toxicity, i.e., restoring growth development and enhancing the defense system. Future regulation of auxin and DIMBOA levels in plants may be possible through appropriate methods, thus regulating the plant growth-defense balance under herbicide stress. Our insight into the interference mechanism of herbicides to the plant growth-defense system will facilitate the design of improved strategies for herbicide detoxification.
Novel self-assembly nano structured organic inorganic hybrid composite: high magnetic mobility and shell-less superhydrophobic-superoleophilic particles for demulsification
Authors: Yu Mingdong , Wang Daobei , Xia Anqi , Wang Dongzhi 
Published: August 2023

Abstract
Nanostructured magnetic particles are promising candidate materials for oil/water separation, demulsification, and detoxification. A nanometer-sized magnetic composites with superhydrophobicity and superoleophilicity surface is produced via self-assembly synthesis using Sol-Gel method. The oil/water separation performances of as prepared Methyltrimethoxysilane (MTMS)/Diethoxymethylsilane (DEMS)-Fe3O4 nanocomposite particles (MTMS/DEMS-Fe3O4 NCPs) nanocomposites as demulsifications were investigated for oil removal. The properties of the composite were characterized using AFM, SEM, FTIR, XRD, Raman, TGA VSM and Interfacial Tension Analysis. The results show that MTMS/DEMS-Fe3O4 NCPs are composed of Fe3O4-SiO2-CH3. More interestingly, the MTMS/DEMS-Fe3O4 NCPs samples showed higher saturation magnetization values (Ms = 78.9 emu/g) compared to the pure Fe3O4 NPs (Ms = 69.6 emu/g). The demulsification efficiency of the MTMS/DEMS-Fe3O4 particles was found to be higher to that of Fe3O4 particles under magnetic control. The effects of Fe3O4 nanoparticles concentration on demulsification, oil absorbency, and oil/water selectivity were also investigated. The materials have good superhydrophobicity/superoleophilicity (CAwater ≈ 160° and CAoil ≈ 0°) and excellent magnetic responsivity. It also show very high efficiency demulsification to oil-in-water emulsions and could quickly absorb floating oils on the surface and heavy oils on the bottom driven by magnet. In particular, the demulsification efficiency could reach about 97.5% at room temperature. Moreover, the preparation process of Superhydrophobic-superoleophilic particles is completely fluoropolymer-free. More importantly, the mixture of oil and demulsifiers could be seperated by ethanol and magnet, which is beneficial to the recycle. With great demulsification and recyclability performance, the superhydrophobic and superoleophilic micro/nano Fe3O4 particles display great promise to achieve industrial applications in the future.
Compact Implantable Antenna Design for Biotelemetry Applications Operating at ISM
Authors: Tariq Rimsha , Raza Ali , Naqvi Syed Aftab , Raza Muhammad , Braaten Benjamin Davis , Anagnostou Dimitris E. , Alonazi Wadi B 
Published: August 2023

Abstract
The bulky size and its complications are the major concerns of the medical fraternity about the implantable devices in a human body. This paper explicates the optimal design of a compact miniaturized implantable Micro-strip Patch Antenna (MPA). Initially, the antenna is designed by applying different miniaturization techniques to operate at Industrial, Scientific and Medical (ISM) band ranging from 2.4 to 2.48GHz. The designed antenna is placed in simulated model of human skin and tested. The radiating geometry of the proposed antenna is optimized to operate at proposed bands as behavior of the antenna is different than free space. A prototype of the antenna tested in simulated model of skin is measured in the free space and compared to simulated results. A good agreement in the simulated and measured result is observed. The size and other parameters of the proposed implantable antenna are compared with state-of-the-art literature, and it is reported that the proposed antenna is miniaturized up to 80%. The proposed antenna has its applications in smart implantable devices operated at ISM frequency band.
Synthesis, Thermal Stability and Antifungal Evaluation of Two New Pyrrole Esters
Authors: Lai Miao , Fan Wenpeng , Chu Wenjuan , Zhang Ruiting , Gao Ziting , Han Lu , Yang Xiaopeng , Wei Yuewei , Tian Haiying , Ji Xiaoming 
Published: August 2023

Abstract
To develop new chemicals that are stable at high temperatures with biological activity, a pyrrole intermediate was firstly synthesized using glucosamine hydrochloride as raw materials through cyclization and oxidation. Further, two novel pyrrole ester derivatives were prepared via Steglich esterification from pyrrole intermediate with vanillin and ethyl maltol, respectively. Nuclear magnetic resonance (1H NMR, 13C NMR), infrared spectroscopy (IR) and high resolution mass spectrometry (HRMS) were used to confirm the target compounds. Thermal behavior of the compounds was investigated by thermogravimetry (TG), differential scanning calorimeter (DSC) and the pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) methods. The plausible pyrolytic mechanism was proposed. Additionally, their biological activities against the pathogens Fusarium. graminearum, Fusarium. oxysporum, Fusarium. moniliforme, Phytophthora. nicotianae, and Rhizoctonia. solani were assessed. These target compounds showed outstanding antifungal activities and the highest inhibitor rates of 62.50% and 68.75% against R. solani with EC50 values of 0.0296 and 0.0200 mg mL-1, respectively. SDHI protein sequence was molecularly docked to identify the binding mechanisms in the active pocket and examine the interactions between both the molecules and the SDHI protein.
Efficacy Analysis of Minimally Invasive Surgery for Raynaud’s Syndrome
Authors: Yu Fengwei , Liu Yongtao , Zhang Chengnian , Pang Botao , Zhang Daijie , Zhao Wei , Li Xuecheng , Yang Weiqiang 
Published: August 2023

Abstract
Background
Raynaud’s syndrome (RS) is a rare autonomic nervous system disorder and is also known as Raynaud’s disease, cold agglutinin disease, etc. With the evolution of microsurgical techniques, undergoing minimally invasive surgery in combination with adventitial release and sympathectomy for the affected limbs greatly improves locoregional blood circulation and neurological function.
Methods
A retrospective study was conducted on RS patients who reported to the Department of Hand & Foot Surgery (Microsurgery), Binzhou Medical University Hospital. The patients were divided into experimental and control groups. Fifteen (5 of whom had fingertip soft tissue necrosis, with no phalangeal exposure or infection) experimental group patients underwent microscopic adventitial release and sympathectomy. They were given nifedipine, conventional lamp, and heat therapies for the affected fingers during the perioperative period, followed by postoperative analgesic drugs. Fifteen control group patients who refused surgery or were treated non-surgically underwent treatment with nifedipine, conventional lamp, and heat therapies for the affected fingers. All patients provided informed consent.
Results
Various outcome measures like the VAS pain score, RCS score, Quick-DASH scale score, digital ulcer score, and cold water stimulation test results in the experimental group were significantly improved when compared with the control group patients; no recurrence was observed during the follow-up.
Conclusion
After adventitial release and sympathectomy in RS patients, improved symptoms, a faster capillary reaction time of the affected fingertips, and significant pain alleviation demonstrated that microscopic adventitial release along with sympathectomy was greatly effective in RS patients.
Head circumference and intelligence, schooling, employment, and income: a systematic review
Authors: Freire Marina B O , Slater Rebeccah , Santos Thiago M , Silva Bruna G C da , Baxter Luke , Menezes Ana M B 
Published: August 2023

Abstract

Background
No consensus exists about the role of head circumference in identifying children at risk of suboptimal development. The objective of this study was to evaluate the association between head circumference and intelligence, schooling, employment, and income. The review 1) summarizes the overall evidence and 2) restricts the evidence to a subset of articles that met minimum quality criteria.
Methods
PubMed, Web of Science, PsycINFO, LILACS, CINAHL, WHO Institutional Repository for Information Sharing and UNICEF Innocenti were searched to identify published studies. Cohort, case-control or cross-sectional studies which evaluated the associations of interest in the general population, premature babies, babies with low birth weight or small for gestational age were included. Two reviewers independently performed study selection, data extraction and quality assessments.
Results
Of 2521 records identified, 115 were included and 21 met the minimum quality criteria. We identidied large heterogeneity and inconsistency in the effect measures and data reported across studies. Despite the relatively large number of included articles, more than 80% presented serious limitations such as severe selection bias and lack of adjustment for confounding. Considering the subset of articles which met the minimum quality criteria, 12 of 16 articles showed positive association between head circumference and intelligence in the general population. However, in premature babies, 2 of 3 articles showed no clear effect. Head circumference was positively associated with academic performance in all investigated samples (5 of 5 articles). No article which evaluated educational attainment and employment met the minimum quality criteria, but the association between head circumference and these outcomes seems to be positive.
Conclusions
Larger head circumferences in the first 1000 days is positively associated with higher levels of intelligence and academic performance in the general population, but there is evidence of non-linearity in those associations. Identifying a group of children in higher risk for worse outcomes by a simple and inexpensive tool could provide an opportunity to mitigate these negative effects. Further research is needed for a deeper understanding of the whole distribution of head circumference and its effect in premature babies. Authors should consider the non-linearity of the association in the data analysis.
Systematic Review Registration:
Association between head circumference and intelligence, educational attainment, employment, and income: A systematic review, CRD42021289998, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021289998
Implementing enhanced m-health mental health screening for adolescents living with HIV transitioning into adult care
Authors: Gitahi Nyawira , Kiplagat Anthony , Waruinge Stella , Lukoye Atwoli , Bukusi Elizabeth 
Published: August 2023

Abstract

Background
Growing evidence indicates that around half of all adolescents and young adults living with Human Immunodeficiency Virus (AYALWHIV) experience mental health difficulties in Africa. Despite this, less than 1% of AYALWHIV receive mental health screening as part of routine care in resource-limited settings. Little is known about the determinants of mental health in this population. The overall objective of this study is to address this mental health gap in this vulnerable population by investigating the feasibility, acceptability and adoptability of a self-administered m-health-based mental health screening tool among Kenyan AYALWHIV. We will also investigate the psycho-social determinants of mental illnesses and resulting virological outcomes.
Methods
This study proposes to use a mixed methods design. We will enroll AYALWHIV aged 15–24 years from eight urban HIV clinics in Nairobi Kenya. We will collect socio-demographic, psycho-social, and viral suppression data from chart abstraction and semi-structured interviews at enrollment. We will use a ready-for-use m-health Open Data Kit (ODK) based self-administered tool that consists of four mental health and substance use screening tools to measure the prevalence and severity of General Anxiety Disorder, Depressive illness, Post-Traumatic Stress Disorder, and substance use. We will assess acceptance of the m-health tool using a brief questionnaire. In-depth interviews will be used to investigate individual-level factors that influence acceptance by AYALWHIV of the self-administered m-health tool and its integration within routine HIV care, and to identify health system barriers and facilitators towards the integration of a digital mental health screening approach as perceived by health care workers.
Discussion
We hypothesize a high level of acceptability of the m-health mental health screening intervention and a high prevalence of mental health difficulties linked to psycho-social factors in this population. We anticipate this study will generate evidence on the rapid, scale-up and sustainable implementation of the tool and illuminate organizational, health care provider, policy maker and intervention-related barriers and facilitators to adoptability. If the intervention is found to be acceptable and feasible, the clinical implication would be to increase the use of the m-health screening tool in routine HIV care among AYALWHIV in Kenya.
Analysis of circRNA and miRNA profiles in type-1 diabetic retinopathy
Authors: Dong Ning , Yang Ming , Li Shuang , Wang Kang 
Published: August 2023

Abstract
Purpose
Diabetic retinopathy (DR) is a microangiopathy of the retina, from which nearly all people with diabetes eventually suffer. However, its pathogenic mechanism remains to be elucidated. Circular RNAs (circRNAs) are endogenous non-coding RNAs that have recently been recognized to play vital roles in DR. This study aimed to explore the role of circRNAs and microRNA (miRNA) in the pathogenesis of DR and to analyze the circRNA-miRNA-mRNA regulation network.
Methods
Sixty rats were randomly assigned to the diabetic and control groups. The retina tissues were extracted for next-generation RNA sequencing and bioinformatics analysis.
Results
A total of 830 circRNAs and 37 miRNAs were differentially expressed in the two groups. Aberrantly expressed genes that may be enriched in the glutamatergic synapse GABAergic synapse, morphine addiction, phosphatidylinsitol signaling pathway, tight junctions, and dopaminergic synapse were revealed by functional annotation. The circRNA-miRNA co-expression networks and the circRNA-miRNA-mRNA co-regulated competing endogenous RNA (ceRNA) network were constructed. Novel-circRNA_0007196 was selected as the target gene.
Conclusions
Different coding and non-coding RNA profiles and genes in the co-regulation network are likely to play essential roles in DR. This study provides new insights into the pathogenic mechanisms and pathological processes of early DR.
Efficacy and Safety of Ketamine-assisted Electroconvulsive Therapy in Major Depressive Episode: A Systematic Review and Network Meta-Analysis
Authors: Rhee Taeho Greg , Shim Sung Ryul , Popp Jonah , Trikalinos Thomas , Rosenheck Robert , Kellner Charles , Seiner Stephen , Espinoza Randall , Forester Brent , McIntyre Roger 
Published: August 2023

Abstract
Objective: To meta-analyze clinical efficacy and safety of ketamine compared with other anesthetic agents in the course of electroconvulsive therapy (ECT) in major depressive episode (MDE).
Methods: PubMed/MEDLINE, Cochrane Library, Embase, GoogleScholar, and US and European trial registries were searched from inception through May 23, 2023, with no language limits. We included RCTs with (1) a diagnosis of MDE; (2) ECT intervention with ketamine and/or other anesthetic agents; and (3) measures included: depressive symptoms, cognitive performance, remission or response rates, and serious adverse events. Network meta-analysis (NMA) was performed to compare ketamine and 7 other anesthetic agents. Hedges’ g standardized mean differences (SMDs) were used for continuous measures, and relative risks (RRs) were used for other binary outcomes using random-effects models.
Results: Twenty-two studies were included in the systematic review. A total of 2,322 patients from 17 RCTs were included in the NMA. The overall pooled SMD of ketamine, as compared with a propofol reference group, was -2.21 (95% confidence interval [CI], -3.79 to -0.64) in depressive symptoms, indicating that ketamine had better antidepressant efficacy than propofol. In a sensitivity analysis, however, ketamine-treated patients had a worse outcome in cognitive performance than propofol-treated patients (SMD, -0.18; 95% CI, -0.28 to -0.09). No other statistically significant differences were found.
Conclusions: Ketamine-assisted ECT is tolerable and may be efficacious in improving depressive symptoms, but a relative adverse impact on cognition may be an important clinical consideration. Anesthetic agents should be considered based on patient profiles and/or preferences to improve effectiveness and safety of ECT use.
The combination of Ephedrae herba and coixol from Coicis semen attenuate adiposity via glucocorticoid receptor regulation
Authors: Yu Ga-Ram , Kim Jai-Eun , Lim Dong-Woo , Park Won-Hwan 
Published: August 2023

Abstract
The enhanced therapeutic effects and mechanisms of certain herbal combination in various herbal prescriptions are mostly unclear. A combination of two herbs, namely Ephedrae herba (EH) and Coicis semen (CS), has been commonly prescribed for obesity. In our previous work, the combination of EH and CS was studied using network pharmacological approach to predict its pharmacological targets and in vitro experiments to evaluate its efficacy on obesity. Although we demonstrated enhanced anti-adiposity effects of the combination on matured adipocytes, the molecular mechanisms and contributing compounds underlying the effects of EH-CS combination on adiposity or adipogenesis were not fully elucidated. The current study adopted integrated bioinformatics analysis to precisely validate potential targets of EH-CS by screening differentially expressed genes (DEGs) of morbid obesity patients from NCBI Gene Expression Omnibus (GEO). Based on the functional cluster analysis of down-regulated DEGs, the anti-adipogenesis mechanism of EH-CS combination was speculated with KEGG enrichment analysis. Furthermore, we investigated the combinational effects of EH and coixol, or stigmasterol, the two compounds in CS which were expected to have main beneficial effects in metabolic diseases. Moreover, distinct effect of the combination on transcriptional activity of glucocorticoid receptor (GR) was investigated using electrophoretic mobility shift assay (EMSA). The EH-CS combination was predicted to modulate down-regulated genes which are involved in KEGG pathways crucial to metabolic disease in morbidly obese individuals. The combination of EH with CS compounds significantly increased the phosphorylation of acetyl-coA carboxylase (ACC), AMP-activated protein kinase (AMPK), and protein kinase B (AKT) in 3T3-L1 cells and decreased intracellular lipid accumulation. The two CS compounds significantly increased the anti-adipogenesis/lipogenesis effects of EH by inhibiting the gene expression levels. Finally, the combination of EH and coixol inhibited dexamethasone-induced GR translocation to the nucleus and transcriptional binding activity in adipocytes. The combination of EH and CS could be considered a therapeutic strategy for treating metabolic diseases, including obesity.