bluuebunny/crossref_metadata_2025_split huggingface dataset:
Herbal Components for the Treatment of Various Kidney Disorders
Authors: Khan Javed , Yadav Shikha , Alam Md. Aftab 
Published: April 2023

Abstract::
Acute kidney injury is described as a loss of renal excretory function that occurs suddenly.
AKI is one of several ailments grouped together as acute kidney diseases and disorders (AKD), in which
progressive degradation of kidney function or persistent renal dysfunction is associated with irreversible
loss of kidney cells and nephrons, potentially leading to chronic kidney disease (CKD). The prevalence
and incidence of KDs are assessed in light of population disparities in the prevalence of risk factors such
as diabetes, hypertension, and obesity. However, the presence of these associated illnesses does not fully
explain the increased rate of progression of chronic renal disease in high-risk patients (CKD). The development
of renal disease is accompanied by a decline in renal function, which eventually leads to renal
failure. The current status of diagnostic testing does not allow for accurate early disease diagnosis, prognosis,
or therapy efficacy monitoring. Despite significant advances in care and understanding of the causes
of acute renal failure (ARF), many aspects of ARF remain controversial, confusing, and uncertain.
Accurate information on the disease's prevalence, genesis, and clinical manifestations is required to successfully
advocate for enough funding and resources to manage the disease. Herbal components for the
treatment of a variety of kidney disorders, and the page includes a list of plants that are good for kidney
treatment. This review focuses on several herbal products used to treat renal problems. It is clear from this
study that medicinal plants play an important role in the fight against many different diseases. Several
different plants and plant extracts have been shown to have beneficial effects in treating renal disease.
These medications have great promise for use in treating kidney damage because of their nephroprotective,
cytoprotective, immunomodulatory, antioxidant, anti-inflammatory, and reducing effects on oxidative
stress, renal hypertension, and blood toxins such as urea, creatinine, and others. Therefore, India's
traditional medicine offers a wide variety of medications that can be utilized in renal illnesses due to their
effectiveness in both treating the ailment and restoring normal kidney function. Therefore, it is suggested
that additional research be conducted to learn many aspects and mechanisms of medications.
Rethinking for Natural Pharmaceutical Technology: Parabens as Cosmetic
Preservatives and their Potential as Chemical Endocrine Disruptors
Authors: Elías Exequiel González , Maria Eugenia Sesto Cabral , Julieta Moreno Maria 
Published: April 2023

Background:
The movement of conscious consumption is growing rapidly. The idea of leaving behind synthetic products and substances that generate waste from their production to their final disposal grows and widens the gap between the old capitalist paradigm and the concept of naturism. It includes environmental awareness, taking care of our body, and the conscious choice of what we eat, wear, and use in daily life, including cosmetic products.

Objective::
This study aimed to explore a new paradigm of formulation and consumption. A group of parabens was selected, and their replacement with preservatives approved for natural cosmetics was proposed. Some of the risks associated with the consumption of parabens in food, cosmetics, and medicines, were also examined. Moreover, the advantages and disadvantages of preservatives for the product and consumer were also discussed.

Methods::
For data collection, publications in indexed journals were searched, with the keywords: parabens, endocrine disrupting chemicals, and skin conditions related to the use of parabens.

Results::
Recent studies have reported that by using parabens in skin products, we create an imbalance in the skin flora. This preservative decreases the defense capacity of our first immune line and causes disorders that lead to irritation, rosacea spots, oiliness, and sectorized peeling. Furthermore, parabens are exogenous substances that alter the functions of the endocrine system and can cause adverse health effects.

Conclusion::

In Argentina, compounds from the paraben family are used by many brands as preservatives, which are dangerous to health and the environment. Therefore, a conscious, sustainable, biodegradable, and cruelty-free alternative is needed to replace parabens in cosmetics
Store-and-Forward Teledermatology for Assessing Skin Cancer in 2023: Literature Review
Authors: Jones Leah Kirsten , Oakley Amanda 
Published: April 2023

Background
The role of teledermatology for skin lesion assessment has been a recent development, particularly, since the COVID-19 pandemic has impacted the ability to assess patients in person. The growing number of studies relating to this area reflects the evolving interest.

Objective
This literature review aims to analyze the available research on store-and-forward teledermatology for skin lesion assessment.

Methods
MEDLINE was searched for papers from January 2010 to November 2021. Papers were searched for assessment of time management, effectiveness, and image quality.

Results
The reported effectiveness of store-and-forward teledermatology for skin lesion assessment produces heterogeneous results likely due to significant procedure variations. Most studies show high accuracy and diagnostic concordance of teledermatology compared to in-person dermatologist assessment and histopathology. This is improved through the use of teledermoscopy. Most literature shows that teledermatology reduces time to advice and definitive treatment compared to outpatient clinic assessment.

Conclusions
Overall, teledermatology offers a comparable standard of effectiveness to in-person assessment. It can save significant time in expediting advice and management. Image quality and inclusion of dermoscopy have a considerable bearing on the overall effectiveness.
Data-Driven Identification of Unusual Prescribing Behavior: Analysis and Use of an Interactive Data Tool Using 6 Months of Primary Care Data From 6500 Practices in England
Authors: Hopcroft Lisa EM , Massey Jon , Curtis Helen J , Mackenna Brian , Croker Richard , Brown Andrew D , O'Dwyer Thomas , Macdonald Orla , Evans David , Inglesby Peter , Bacon Sebastian CJ , Goldacre Ben , Walker Alex J 
Published: April 2023

Background
Approaches to addressing unwarranted variation in health care service delivery have traditionally relied on the prospective identification of activities and outcomes, based on a hypothesis, with subsequent reporting against defined measures. Practice-level prescribing data in England are made publicly available by the National Health Service (NHS) Business Services Authority for all general practices. There is an opportunity to adopt a more data-driven approach to capture variability and identify outliers by applying hypothesis-free, data-driven algorithms to national data sets.

Objective
This study aimed to develop and apply a hypothesis-free algorithm to identify unusual prescribing behavior in primary care data at multiple administrative levels in the NHS in England and to visualize these results using organization-specific interactive dashboards, thereby demonstrating proof of concept for prioritization approaches.

Methods
Here we report a new data-driven approach to quantify how “unusual” the prescribing rates of a particular chemical within an organization are as compared to peer organizations, over a period of 6 months (June-December 2021). This is followed by a ranking to identify which chemicals are the most notable outliers in each organization. These outlying chemicals are calculated for all practices, primary care networks, clinical commissioning groups, and sustainability and transformation partnerships in England. Our results are presented via organization-specific interactive dashboards, the iterative development of which has been informed by user feedback.

Results
We developed interactive dashboards for every practice (n=6476) in England, highlighting the unusual prescribing of 2369 chemicals (dashboards are also provided for 42 sustainability and transformation partnerships, 106 clinical commissioning groups, and 1257 primary care networks). User feedback and internal review of case studies demonstrate that our methodology identifies prescribing behavior that sometimes warrants further investigation or is a known issue.

Conclusions
Data-driven approaches have the potential to overcome existing biases with regard to the planning and execution of audits, interventions, and policy making within NHS organizations, potentially revealing new targets for improved health care service delivery. We present our dashboards as a proof of concept for generating candidate lists to aid expert users in their interpretation of prescribing data and prioritize further investigations and qualitative research in terms of potential targets for improved performance.
Fertility Preservation Techniques in Neuro-Oncology Patients: Protocol for a Systematic Review
Authors: Osborne-Grinter Maia , Bianca Offorbuike Chiamaka , Sanghera Jasleen , Kaliaperumal Chandrasekaran 
Published: April 2023

Background
Advancements in cancer treatments have successfully improved central nervous system (CNS) cancer survivorship and overall quality of life. As a result, the awareness of the importance of fertility preservation techniques is increasing. Currently, a range of established techniques, such as oocyte cryopreservation and sperm cryopreservation, are available. However, oncologists may be hesitant to refer patients to a reproductive specialist.

Objective
The primary aim of the proposed systematic review is to assess the best evidence for fertility preservation techniques used in patients with CNS cancers. It also aims to evaluate outcomes related to their success and complications.

Methods
This protocol was produced in adherence with the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols). Electronic databases will be systematically searched to identify studies that meet our eligibility criteria. Studies will be included if they report at least one type of fertility preserving or sparing technique in male patients of any age and female patients aged <35 years. Animal studies, non-English studies, editorials, and guidelines will be excluded from the review. From the included studies, data will be extracted and synthesized by using a narrative approach and summarized in tables. The primary outcome will be the number of patients successfully undergoing a fertility preservation technique. The secondary outcomes will include the number of retrieved oocytes, the number of oocytes or embryos vitrified for cryopreservation, clinical pregnancy, and live birth. The quality of the included studies will be assessed by using the National Heart, Lung, and Blood Institute risk-of-bias tool for any type of study.

Results
The systematic review is expected to be completed by the end of 2023, and results will be published in a peer-reviewed journal and on PROSPERO.

Conclusions
The proposed systematic review will summarize the fertility preservation techniques available for patients with CNS cancers. Given the improvement in cancer survivorship, it is becoming increasingly important to educate patients about fertility preservation techniques. There are likely to be several limitations to this systematic review. Current literature is likely to be of low quality due to insufficient numbers, and there may be difficulty in accessing data sets. However, it is our hope that the results from the systematic review provide an evidence base to help inform the referral of patients with CNS cancers for fertility preservation treatments.

Trial Registration
PROSPERO CRD42022352810; https://tinyurl.com/69xd9add

International Registered Report Identifier (IRRID)
PRR1-10.2196/44825
Tectonics, magmatism and crustal structure of Mexico
Authors: Urrutia-Fucugauchi Jaime 
Published: April 2023

978 / 5.000

Resultados de traducción

Desde su establecimiento y posterior desarrollo en la década de 1980-1989, el Programa Internacional de Litósfera (ILP) ha sido una importante adición a la investigación internacional en ciencias de la tierra, habiendo llevado a cabo un programa ambicioso y promovido numerosas iniciativas. La creciente conciencia de los ciclos globales, los mecanismos de retroalimentación, los procesos no lineales, etc. han llevado al surgimiento de programas como el Geosfera-Biosfera (IGBP), el Cambio Global y los Programas del Sistema Terrestre. Muchos fenómenos en los diversos campos que vinculan los diversos sistemas terrestres, que anteriormente se habían estudiado como entidades separadas de la geosfera, la biosfera, la hidrosfera y la atmósfera, ahora se están investigando dentro de un marco integrado. La conjunción de ciencias terrestres, atmosféricas, oceánicas y biológicas sólidas que incluyen: geofísica, geología, geoquímica, ciencias atmosféricas, biología, ecología, ciencias ambientales, oceanografía y muchos otros campos proporcionará un paradigma global.doi: sin doi
Socio-Communicative Technology of Working with Public Opinion in the Context of an Environmental Incident
Authors: Panova E. V. 
Published: April 2023

The article is devoted to the problem of resolving environmental incidents of various origins, building an effective crisis management model. The article examines the analysis of crisis communications, subjects of environmental communications, sources of information dissemination, response tools. Target. Formation of a successful practice of overcoming the environmental crisis based on the development of an effective communication strategy and action model. Methodology. In the course of the research, in order to form a theoretical base, the author turned to the works of Russian and foreign researchers studying the issues of social and communicative technologies, crisis communications. In the practical part, materials from the mass media, information from state bodies, and the author’s own experience in resolving crisis situations were used. To draw conclusions, strategies and actions in three different categories of environmental crises were evaluated and the results they led to. Results. Issues of environmental protection and the quality of ecology are increasingly of concern to citizens, they quickly move from social to political. The ability to competently respond to overcoming environmental crises, minimizing their consequences can not only maintain the official position of a representative of state authorities and business stability, but also ensure social stability in society and trust in management institutions.
Differential associations of glutamic acid decarboxylase antibodies (GADA) and C-peptide with insulin initiation, glycemic responses and severe hypoglycemia in patients diagnosed with type 2 diabetes
Authors: Fan Baoqi , K.P. Lim Cadmon , W.M. Poon Emily , S.H. Lau Eric , Wu Hongjiang , Yang Aimin , Shi Mai , H.T. Tam Claudia , Y.S. Wong Samuel , Kam-Pui Lee Eric , H.T. Wang Maggie , H.S. Chu Natural , Ozaki Risa , P.S. Kong Alice , Chow Elaine , C.W. Ma Ronald , O.Y. Luk Andrea , C.N. Chan Juliana 
Published: April 2023

<p> </p>
<p><strong>Objective</strong></p>
<p>We examined the associations of glutamic acid decarboxylase antibodies (GADA) and C-peptide (CP) with insulin initiation, glycemic responses and severe hypoglycemia in type 2 diabetes (T2D).</p>
<p><strong>Research Design and Methods</strong></p>
<p>In 5230 Chinese patients with T2D (mean±SD age: 56.5±13.9 years, diabetes duration (median, IQR): 6 (1-12) years, 47.6% men) enrolled consecutively in 1996-2012 and prospectively observed till 2019, we retrospectively measured fasting CP and GADA in stored serum and examined their associations with aforementioned outcomes.</p>
<p><strong>Results</strong></p>
<p>At baseline, 28.6% had low CP (<200 pmol/L) (n=1494) and 4.9% (n=257) had positive GADA (GADA+). In the low-CP group, 8.0% had GADA+ and in the GADA+ group, 46.3% had low CP. The GADA+ group had an adjusted hazard ratio (aHR) of 1.46 (95% CI: 1.15-1.84, <em>p=</em>0.002) for insulin initiation versus the GADA- group, while the low-CP group had an aHR of 0.88 (0.77-1.00, <em>p=</em>0.051) versus the high-CP group. Following insulin initiation, the GADA+ plus low-CP group had the largest decrements in HbA1c (-1.9% at month 6; -1.5% at month 12) versus -1% in the other 3 groups. The aHR of severe hypoglycemia was 1.29 [(95% CI 1.10-1.52), <em>p=</em>0.002] in the low-CP and 1.38 [(95% CI 1.04-1.83) <em>p=</em>0.024] in the GADA+ group. </p>
<p><strong>Conclusions</strong></p>
<p>There is considerable heterogeneity in autoimmunity and beta-cell dysfunction in T2D with GADA+ and high CP associated with early insulin initiation while GADA+ and low CP, increased risk of severe hypoglycemia. Extended phenotyping is warranted to increase the precision of classification and treatment in T2D.</p>
The Free Movement of Albanian Goods toward the European Union
Authors: Mahilaj Sara , Cenaj Marko 
Published: April 2023

The free movement of goods is one of the most debatable topics for academics that are focused on European law. One of the four fundamental freedoms of the internal market with the potential to benefit consumers. Because of its complexities, it continues to be important and needs to be continuously studied and analyzed. Given this, the main goal of this paper is to prove if the free movement of Albanian goods toward the European Union is a positive indicator or not for the future. It will be an examination to better understand where we are as a country. To better understand the situation, the analysis will begin with a general overview of the free movement of goods and its significance, followed by a look at the opportunities and challenges that Albania will most likely face in the future. This study attempts to examine the progress of Albania in the area of the free movement of goods, as a country that aspires to be part of the European Union. It models such an analysis, which begins with the first agreement created for this purpose, such as the Stabilization and Association Agreement, and concludes with the most recent creation, The Open Balkan. The analysis conducted through this lens leads Albania to a better future if it adapts to European Union standards, but things cannot be that simple. The true challenges lie deeper and will be visible in the near future.
Dominance of Cyperus kyllingia Endl. at guava orchard and its possible resistance to glyphosate
Authors: Ferdinans  , Guntoro Dwi , Sudradjat  
Published: April 2023

Weed resistance, indicated by increasing the level of herbicide for control, might arise due to the continuous use of similar herbicides in the long term without any herbicide rotation. The objective of this research was to evaluate the status of dominant weeds in a guava orchard to determine weed control strategies. The research was carried out from November 2020 to June 2021 at Agribusiness Technology Park IPB, Bogor. Vegetation analysis to define dominance was carried out at 4 blocks using the square method. In each block, five sampling points were randomly selected. Seeds of C. kyllingia were collected and planted as many as 25 seedlings in polybags. Glyphosate herbicide was applied onto C. kyllingia in 3 replications using 9 doses, i.e., 0 (D0), 60.75 (D1), 121.5 (D2), 243 (D3), 486 (D4), 972 (D5), 1944 (D6), 3888 (D7), and 7776 g ha-1 (D8). C. kyllingia mortality percentages were analyzed using linear regression to obtain LD50. The results showed that the dominant weed was C. kyllingia. Block 4 showed the highest significant LD50 value at 759.11 g ha-1 with a resistance index of 2.67 (reduced sensitivity). The presence of dominant C. kyllingia was identified only at block 4, indicating the dominance could correlate with increasing resistance of the particular weed.
Keywords: doses; EPSPS; glyphosate; LD50; sedges; vegetation analysis
APENDICITE AGUDA: REVISÃO DE LITERATURA
Authors: Silva Juremeira Layane Thainá , Bianchi Mantovan Lívia , Pereira da Silva Veridiana , Dourado Leite Karina , Damasceno de Oliveira Laira Lúcia 
Published: April 2023

A apendicite aguda afeta cerca de 10% da população e é, portanto, uma das emergências cirúrgicas mais prevalentes em todo o mundo, representando um importante desafio para os sistemas de saúde. No entanto, a etiologia continua pouco compreendida e o diagnóstico permanece multifatorial. Apesar da disponibilidade de biomarcadores que auxiliam no diagnóstico, a baixa sensibilidade e especificidade limitam seu impacto clínico. O objetivo deste estudo foi avaliar e sintetizar os resultados obtidos a partir de um levantamento bibliográfico sobre essa patologia, onde foram verificadas informações sobre o diagnóstico e quais biomarcadores e tratamentos atuais estão disponíveis. Para isso, foram revisados diversos artigos científicos sobre o tema, demonstrando que, apesar da diversidade de exames e biomarcadores, o diagnóstico da apendicite aguda permanece complexo. A partir dos resultados analisados, foi verificado que nenhum marcador isolado ou outros testes podem identificar a doença com alta especificidade e sensibilidade, indicando a necessidade de mais estudos sobre a combinação desses marcadores para auxiliar no diagnóstico da apendicite aguda. Neste contexto, o tratamento da apendicite consiste na abordagem cirúrgica com apendicectomia aberta ou laparoscópica. No entanto, a antibioticoterapia pode ser o tratamento de escolha em pacientes com apendicite não complicada, demonstrando ser uma medida terapêutica eficaz pela redução das chances de complicações e nas licenças médicas, além da diminuição do uso de medicação para a dor.
"DIAGNÓSTICO PRECOCE DE ACETONEMIA SUBCLÍNICA EM VACAS HOLANDESAS POR MENSURAÇÃO DE CORPOS CETÔNICOS”
Authors: Grosse Hedron Victor , Hartmann Welington , De Oliveira Rodrigo Azambuja Machado 
Published: April 2023

O trabalho foi realizado em uma fazenda de exploração leiteira em Castrolanda, no município de Castro – PR. O sistema de manejo é free-stall, com 220 vacas da raça Holandesa com RHA305 de 6.740 litros. Foram coletadas amostras de sangue de 18 vacas de pré-parto, 4 dias antes da data prevista para o parto; e nos dias 4, 7 e 12 pós-parto, mediante punção venosa coccígea, utilizando-se SnapTest digital Ketovet®, constituindo 72 amostras, no período de fevereiro a maio de 2020. Em 4 vacas o BHB do sangue total apresentou-se acima do limite para cetose subclínica no quarto dia após o parto e 17 apresentaram-se acima do limite no sétimo dia, declinando em seguida, principalmente devido às intervenções clínicas. As médias e desvios-padrão foram: D -4: 0,89 ± 0,257061; D 4: 1,05 ± 0,283279; D 7: 1,81 ± 0,456131; e D 12: 1,19 ± 0,437762. O benefício do monitoramento de BHB foi a imediata intervenção clínica, evitando-se a severidade por instalação de quadro clínico e as enfermidades concomitantes.