bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endothelial Response to Type I Interferon Contributes to Vasculopathy and Fibrosis and Predicts Disease Progression of Systemic Sclerosis
Authors: Yin Hanlin , Distler Oliver , Shen Lichong , Xu Xiaojiang , Yuan Ye , Li Rui , Liu Bei , Li Qianqian , Huang Qianru , Xie Feng , Zhang Zhiliang , Liang Rui , Dai Xueyu , Chen Xiaoxiang , Li Bin , Yan Qingran , Lu Liangjing 
Published: July 2023

ObjectiveInterferon (IFN)‐1 signatures are a hallmark of patients with systemic sclerosis (SSc). However, its significance in clinical stratification and contribution to deterioration still need to be better understood.MethodsFor hypothesis generation, we performed single‐cell RNA sequencing (scRNA‐seq) on skin biopsies (four patients with SSc and two controls) using the BD Rhapsody platform. Two publicly available data sets of skin scRNA‐seq were used for validation (GSE138669: 12 patients with diffuse cutaneous SSc [dcSSc] and 10 controls; GSE195452: 52 patients with dcSSc and 41 patients with limited cutaneous SSc [lcSSc] and 54 controls). The IFN‐1 signature was mapped, functionally investigated in a bleomycin plus IFNα‐2 adenovirus‐associated virus (AAV)–induced model and verified in an SSc cohort (n = 61).ResultsThe discovery and validation data sets showed similar findings. Endothelial cells (ECs) had the most prominent IFN‐1 signature among dermal nonimmune cells. The EC IFN‐1 signature was increased both in patients with SSc versus controls and in patients with dcSSc versus those with lcSSc. Among EC subclusters, the IFN‐1 signature was statistically higher in the capillary ECs of patients with dcSSc, which was higher than those in patients with lcSSc, which in turn was higher than those in healthy controls (HCs). Endothelial‐to‐mesenchymal transition (EndoMT) scores increased in parallel. Deteriorated bleomycin‐induced dermal fibrosis, EndoMT, and perivascular fibrosis and caused blood vessel loss with EC apoptosis. Vascular myxovirus resistance (MX) 1, an IFN‐1 response protein, was significantly increased both in total SSc versus HC skin and in dcSSc versus lcSSc skin. Baseline vascular MX1 performed similarly to skin score in predicting disease progression over 6 to 34 months in total SSc and was superior in the dcSSc subpopulation.ConclusionThe EC IFN‐1 signature distinguished SSc skin subtypes and disease progression and may contribute to vasculopathy and fibrosis.
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Distinct Scleroderma Autoantibody Profiles Stratify Patients for Cancer Risk at Scleroderma Onset and During the Disease Course
Authors: Kim Ji Soo , Woods Adrianne , Gutierrez‐Alamillo Laura , Laffoon Maureen , Wigley Fredrick M. , Hummers Laura K. , Rosen Antony , Zeger Scott , Domsic Robyn T. , Casciola‐Rosen Livia , Shah Ami A. 
Published: July 2023

ObjectivesWe examined whether an array of scleroderma autoantibodies associates with risk of cancer and could be useful tools for risk stratification.MethodsScleroderma cancer cases and scleroderma controls without cancer from the Johns Hopkins Scleroderma Center and the University of Pittsburgh Scleroderma Center were studied. Sera were assayed by Lineblot and enzyme‐linked immunosorbent assay (ELISA) for autoantibodies against centromere, topoisomerase 1, RNA polymerase (POLR) 3, PM/Scl, Th/To, NOR90, U3 RNP, Ku, Ro52, U1RNP, and RNPC3. Logistic regression models were constructed to examine whether distinct autoantibodies associated with overall cancer at any time and cancer‐associated scleroderma (cancer occurring three years before and after scleroderma onset). The effects of having more than one autoantibody on cancer were further examined using random forest analysis.ResultsA total of 676 cases and 687 controls were studied. After adjusting for relevant covariates, anti‐POLR3 (odds ratio [OR] 1.47, 95% confidence interval [CI] 1.03–2.11) and monospecific anti‐Ro52 (OR 2.19, 95% CI 1.29–3.74) were associated with an increased overall cancer risk, whereas anticentromere (OR 0.69, 95% CI 0.51–0.93) and anti‐U1RNP (OR 0.63, 95% CI 0.43–0.93) were associated with lower risk. When examining risk of cancer‐associated scleroderma, these immune responses remained associated with increased or decreased risk: anti‐POLR3 (OR 2.28, 95% CI 1.33–3.91), monospecific anti‐Ro52 (OR 2.58, 95% CI 1.05–6.30), anticentromere (OR 0.39, 95% CI 0.20–0.74), and anti‐U1RNP (OR 0.32, 95% CI 0.11–0.93). Anti‐Ro52 plus anti‐U1RNP or anti‐Th/To was associated with decreased cancer risk compared with anti‐Ro52 alone.ConclusionsThese data suggest that five distinct scleroderma immune responses, alone or in combination, may be useful tools to stratify the risk of cancer for scleroderma patients. Further study examining cancer risk in autoantibody subgroups relative to the general population is warranted.image
Zum Nachweis gegen Versagen des Erdwiderlagers mit der Finite‐Elemente‐Methode
Authors: Jürgens Hauke , Henke Sascha 
Published: July 2023

AbstractDie Anwendung der Finite‐Elemente‐Methode (FEM) hat sich in der Geotechnik in den letzten Jahrzehnten zur Prognose von auftretenden Verformungen im Grenzzustand der Gebrauchstauglichkeit (SLS) etabliert. Standsicherheitsnachweise im Grenzzustand der Tragfähigkeit (ULS) werden in der Praxis nur bedingt unter Verwendung der FEM geführt und sind aktuell noch Stand der Forschung. Durch die Neuordnung des Eurocodes 7 sollen zukünftig numerische Methoden hinsichtlich der Anwendung im ULS normativ geregelt werden. Offen hierbei ist bisher der Umgang mit den zusätzlich erforderlichen Nachweisen des deutschen Nationalen Anhangs und der DIN 1054. Im vorliegenden Beitrag wird diesbezüglich eine Vorgehensweise zur numerischen Nachweisführung gegen Versagen bodengestützter Wände durch Drehung (bzw. Nachweis gegen Versagen des Erdwiderlagers) vorgestellt. In Anlehnung an die bereits etablierte Festigkeitsreduktionsmethode wird hierbei so vorgegangen, dass die Wichte des Bodens
und die Kohäsion
auf der Erdwiderstandsseite bis zum Erreichen eines Bruchzustands reduziert werden. Auf Grundlage dessen wird ein Sicherheitsfaktor für die vorhandene Einbindetiefe der Verbauwand definiert und darüber der Nachweis im ULS geführt. Im Anschluss erfolgt ein Vergleich mit dem analytischen Nachweisverfahren, womit Systemreserven durch die Verwendung der FEM identifiziert werden.
Hybrid High‐Voltage LiNi0.5Mn1.5O4/Graphite Cathodes Enabling Rechargeable Batteries with Simultaneous Anion‐ and Cation Storage
Authors: Künne Sven , Hesper Jakob Michael , Lein Tobias , Voigt Karsten , Mikhailova Daria , Michaelis Alexander , Winter Martin , Placke Tobias , Heubner Christian 
Published: July 2023

AbstractA hybrid cathode concept that targets combining the specific advantages of Li‐ion batteries and dual‐ion batteries is proposed. LiNi0.5Mn1.5O4 (LNMO), (de)inserting Li+, and graphite, capable to (de)intercalate PF6− present in the electrolyte, are combined in one cathode, aiming for synergy effects due to the presence of two electrochemically active species to overcome rate limitations caused by electrolyte depletion. Hybrid cathodes of different compositions and designs are prepared and investigated regarding their properties and the storage mechanism using electrochemical analyses combined with operando XRD and extensive materials characterization, including scanning electron microscopy and energy‐dispersive X‐ray spectroscopy. Finally, hybrid cathodes with higher areal capacity are prepared and investigated regarding rate performance. Model‐based analysis of the results reveals design criteria and material properties required to achieve synergistic effects between the components in hybrid cathodes. These insights lay the foundation for a new type of battery with advantageous properties in terms of cost, environmental friendliness, and electrochemical performance.
Protein fouling during constant‐flux virus filtration: Mechanisms and modeling
Authors: Peles Joshua , Cacace Benjamin , Carbrello Christina , Giglia Sal , Zydney Andrew L. 
Published: July 2023

AbstractAs biomanufacturers consider the transition from batch to continuous processing, it will be necessary to re‐examine the design and operating conditions for many downstream processes. For example, the integration of virus removal filtration in continuous biomanufacturing will likely require operation at low and constant filtrate flux instead of the high (constant) transmembrane pressures (TMPs) currently employed in traditional batch processing. The objective of this study was to examine the effect of low operating filtrate flux (5–100 L/m2/h) on protein fouling during normal flow filtration of human serum Immunoglobulin G (hIgG) through the Viresolve® Pro membrane, including a direct comparison of the fouling behavior during constant‐flux and constant‐pressure operation. The filter capacity, defined as the volumetric throughput of hIgG solution at which the TMP increased to 30 psi, showed a distinct minimum at intermediate filtrate flux (around 20–30 L/m2/h). The fouling data were well‐described using a previously‐developed mechanistic model based on sequential pore blockage and cake filtration, suitably modified for operation at constant flux. Simple analytical expressions for the pressure profiles were developed in the limits of very low and high filtrate flux, enabling rapid estimation of the filter performance and capacity. The model calculations highlight the importance of both the pressure‐dependent rate of pore blockage and the compressibility of the protein cake to the fouling behavior. These results provide important insights into the overall impact of constant‐flux operation on the protein fouling behavior and filter capacity during virus removal filtration using the Viresolve® Pro membrane.
Worldwide trends in esophageal cancer survival, by sub‐site, morphology, and sex: an analysis of 696,974 adults diagnosed in 60 countries during 2000‐2014 (CONCORD‐3)
Authors: Matz Melissa , Valkov Mikhail , Šekerija Mario , Luttman Sabine , Caldarella Adele , Coleman Michel P , Allemani Claudia ,   the CONCORD Working Group
Published: July 2023

AbstractBackgroundEsophageal cancer survival is poor worldwide, though there is some variation. Differences in the distribution of anatomical sub‐site and morphological sub‐type may help explain international differences in survival for all esophageal cancers combined. We estimated survival by anatomic sub‐site and morphological sub‐type to understand further the impact of topography and morphology on international comparisons of esophageal cancer survival.MethodsWe estimated age‐standardized one‐year and five‐year net survival among adults (15‐99 years) diagnosed with esophageal cancer in each of 60 participating countries to monitor survival trends by calendar period of diagnosis (2000‐2004, 2005‐2009, 2010‐2014), sub‐site, morphology, and sex.ResultsFor adults diagnosed during 2010‐2014, tumors in the lower third of the esophagus were the most common, followed by tumors of overlapping sub‐site and sub‐site not otherwise specified. The proportion of squamous cell carcinomas diagnosed during 2010‐2014 was generally higher in Asian countries (50%‐90%), while adenocarcinomas were more common in Europe, North America and Oceania (50%‐60%). From 2000‐2004 to 2010‐2014, the proportion of squamous cell carcinoma generally decreased, and the proportion of adenocarcinoma increased. Over time, there were few improvements in age‐standardized five‐year survival for each sub‐site. Age‐standardized one‐year survival was highest in Japan for both squamous cell carcinoma (67.7%) and adenocarcinoma (69.0%), ranging between 20%‐60% in most other countries. Age‐standardized five‐year survival from squamous cell carcinoma and adenocarcinoma was similar for most countries included, around 15%‐20% for adults diagnosed during 2010‐2014, though international variation was wider for squamous cell carcinoma. In most countries, survival for both squamous cell carcinoma and adenocarcinoma increased by less than 5% between 2000‐2004 and 2010‐2014.ConclusionsEsophageal cancer survival remains poor in many countries. The distributions of sub‐site and morphological sub‐type vary between countries, but these differences do not fully explain international variation in esophageal cancer survival.
Hepatoblastoma with neonatal necrotizing enterocolitis: Two case reports
Authors: He Sidou , Wang Xisi , Duan Chao , Zhao Wen , Jiang Chiyi , Zhang Shihan , Jian Binglin , Yang Wei , Yu Tong , Fu Libing , Wang Huanmin , Ma Xiaoli 
Published: July 2023

AbstractWe report two children with hepatoblastoma (HB) with a history of neonatal necrotizing enterocolitis (NEC). Case 1 was diagnosed with HB at 5 months of age. Liver enlargement was found during the NEC operation at 3 months of age and then was clinically diagnosed by imaging. After six chemotherapy courses, a partial hepatectomy was performed. Three months after ceasing the chemotherapy, a chest computed tomography scan suggested that distant metastasis of the tumor should be considered, and the lesion was removed. However, 9 months after the operation, alpha‐fetoprotein concentrations were increased, and abdominal imaging showed a recurrence of the tumor in situ, resulting in a hepatectomy. Case 2 was diagnosed with NEC shortly after birth and underwent an intestinal resection and anastomosis 1 month later. He was diagnosed with HB at 3 years of age. Hepatectomy was performed after five courses of chemotherapy. Chemotherapy was stopped after 10 courses, and alpha‐fetoprotein concentrations were normal. At present, both children have survived and are in a healthy condition. Physicians should be aware of the possibility of HB and a history of NEC in children. Premature birth and low birth weight are common factors leading to the pathogenesis of HB and NEC. The association between these two diseases requires further study.
Individual and joint effect of socioeconomic status and lifestyle factors on cancer in Korea
Authors: Tran Chi Lan , Choi Kui Son , Kim Sun‐Young , Oh Jin‐Kyoung 
Published: July 2023

AbstractBackgroundThere is limited evidence on the individual and joint effect of socioeconomic status (SES) and unhealthy lifestyle on cancer. Therefore, this study aimed to examine the effects of these factors on cancer incidence and mortality.MethodsIn this population‐based cohort study, income was used as the proxy of SES. A combined unhealthy lifestyle score was obtained using data on smoking, alcohol consumption, physical activity, and body mass index. Hazard ratios were estimated using a Cox proportional hazards model.ResultsThe study included data on 8,353,169 participants (median follow‐up period, 17 years). Although the association between low income and cancer incidence varied depending on cancer type, low income consistently increased the risk of cancer‐related death with a social gradient. Unhealthy behaviors increased the risk of cancer incidence and mortality, except for thyroid and breast cancer in women and prostate cancer in men. Compared with the wealthiest and healthiest individuals, the poorest and unhealthiest men and women showed 2.1‐fold (2.05–2.14) and 1.36‐fold (1.31–1.41) higher risk of cancer‐related death, respectively. The joint effect was most robust for lung, liver, head, and neck cancers in men and liver and cervical cancers in women; further, the effect was stronger with cancer‐specific mortality than with incidence.ConclusionIn conclusion, income and combined healthy lifestyle behaviors have individual and joint effects on cancer incidence and mortality. The effect varies by cancer type and sex.
Changes in spatial clusters of cancer incidence and mortality over 15 years in South Korea: Implication to cancer control
Authors: Nguyen Cham Thi , Song Insang , Jung Inkyung , Choi Yoon‐Jung , Kim Sun‐Young 
Published: July 2023

AbstractBackgroundThe temporal investigation of high‐risk areas of cancer incidence and mortality can provide practical implications in cancer control. We aimed to investigate the changes in spatial clusters of incidence and mortality from 1999 through 2013 by major cancer types in South Korea.MethodsWe applied flexible scan statistics to identify spatial clusters of cancer incidence and mortality by three 5‐year periods and seven major cancer types using the counts of new cases and deaths and population in 244 districts during 1999–2013. Then, we compared the changes across three periods in the locations of primary clusters of incidence and mortality by cancer types. To explore the determinants that possibly affect cancer cluster areas, we compared geographic characteristics between clustered and non‐clustered areas.ResultsWhile incidence clusters for lung, stomach, and liver cancer remained in the same areas over 15 years, mortality clusters were relocated to the areas similar to those of incidence clusters. In contrast, colorectal, breast, cervical, and prostate cancer displayed consistently different locations of clusters over time, indicating the disappearance of existing clusters and the appearance of new clusters. Cluster areas tended to show higher portions of older population, unemployment, smoking, and cancer screening compared to non‐cluster areas particularly for mortality.ConclusionsOur findings of diverse patterns of changes in cancer incidence and mortality clusters over 15 years can indicate the degree of effectiveness in cancer prevention and treatment depending on the area and suggest the need for area‐specific applications of different cancer control programs.
Protective Effects of Caffeine on Chikungunya and Zika Virus Infections: An in Vitro and in Silico Study
Authors: de Jesús López Medina Yeferson , Tamayo‐Molina Yordi Sebastián , Valdés‐López Juan Felipe , Urcuqui‐Inchima Silvio 
Published: July 2023

AbstractInfection by viruses Chikungunya (CHIKV) and Zika (ZIKV) continue to be serious problems in tropical and subtropical areas of the world. Here, we evaluated the antiviral and virucidal activity of caffeine against CHIKV and ZIKV in Vero, A549, and Huh‐7 cell lines. Results showed that caffeine displays antiviral properties against both viruses. By pre‐and post‐infection treatment, caffeine significantly inhibited CHIKV and ZIKV replication in a dose‐dependent manner. Furthermore, caffeine showed a virucidal effect against ZIKV. Molecular docking suggests the possible binding of caffeine with envelope protein and RNA‐dependent RNA polymerase of CHIKV and ZIKV. This is the first study that showed an antiviral effect of caffeine against CHIKV and ZIKV. Although further studies are needed to better understand the mechanism of caffeine‐mediated repression of viral replication, caffeine appears to be a promising compound that could be used for in vivo studies, perhaps in synergy with other compounds present in daily beverages.
Application of Metal/Covalent Organic Frameworks in Separators for Metal‐Ion Batteries
Authors: Song Xin , Xu Xijun , Liu Jun 
Published: July 2023

AbstractMetal‐organic frameworks (MOFs) and covalent organic frameworks (COFs) are two emerging families of functional materials that have found widespread applications in various fields. With the unique features of large surface area, tunable pore structure, high porosity, and easy surface functionalization, they are considered a kind of promising separators candidates for novel separators in rechargeable batteries. Over the years, many studies on the application of MOF/COF‐based separators have been reported with excellent performance. Herein, we highlight the recent progress of MOF/COF separators for advanced batteries. Firstly, the key properties of MOF/COF separators are presented. Then, we summarize the fabrication methods of MOF/COF separators. Afterward, an overview of the applications of MOF/COF based separators in lithium‐based batteries, sodium‐based batteries, and other secondary batteries. Finally, we present a summary and future outlook of MOF/COF separators, including their potential and current challenges.
A taxonomy and survey of big data in social media
Authors: Hemmati Atefeh , Arzanagh Hanieh Mohammadi , Rahmani Amir Masoud 
Published: July 2023

SummaryExamining the particular value of each platform for big data would be difficult because of the variety of social media forms and sizes. Using social media to objectively and subjectively analyze large groups of individuals makes it the most effective tool for this task. There are numerous sources of big data within the organization. Social media can be identified by the interaction and communication it facilitates. Utilizing social media has become a daily occurrence in modern society. In addition, this frequent use generates data demonstrating the importance of researching the relationship between big data and social media. It is because so many internet users are also active on social media. We conducted a systematic literature review (SLR) to identify 42 articles published between 2018 and 2022 that examined the significance of big data in social media and upcoming issues in this field. We also discuss the potential benefits of utilizing big data in social media. Our analysis discovered open problems and future challenges, such as high‐quality data, information accessibility, speed, natural language processing (NLP), and enhancing prediction approaches. As proven by our investigations of evaluation metrics for big data in social media, the distribution reveals that 24% is related to data‐trace, 12% is related to execution time, 21% to accuracy, 6% to cost, 10% to recall, 11% to precision, 11% to F1‐score, and 5% run time complexity.
Enhanced Catalytic Aryl Alkene Oxidation by Constructing Hierarchical Polyoxometalate‐Based Metal‐Organic Framework
Authors: Jiang Yue , Liang Yan , Zhang Mingxia , Zhang Zhong , Liu Yiwei 
Published: July 2023

AbstractAchieving highly selective oxidation of aryl alkenes to aldehydes is of great significance in chemical industry. Herein, the performance of catalytic aryl alkene oxidation is enhanced via constructing a hierarchical fractal polyoxometalate‐based metal–organic framework (POM@MOF) containing hierarchical pores and layered surface structure, which improve the mass transfer efficiency of substrates and increase the accessibility to active POMs clusters. Accordingly, the activity of fractal POM@MOF is increased by 4.8 times compared with microporous counterpart in 4‐tert‐butylstyrene oxidation to aldehyde product. This work paves a way for designing efficient catalysts for selective oxidation of aryl alkenes via increasing the accessibility of active sites and broadening the diffusion channels by hierarchical construction.
Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by HiFi sequencing
Authors: Miranda Jaime A. , Fenner Kristina , McKinzie Page B. , Dobrovolsky Vasily N. , Revollo Javier R. 
Published: July 2023

AbstractDNA base editors (BEs) composed of a nuclease‐deficient Cas9 fused to a DNA‐modifying enzyme can achieve on‐target mutagenesis without creating double‐strand DNA breaks (DSBs). As a result, BEs generate far less DNA damage than traditional nuclease‐proficient Cas9 systems, which do rely on the creation of DSBs to achieve on‐target mutagenesis. The inability of BEs to create DSBs makes the detection of their undesired off‐target effects very difficult. PacBio HiFi sequencing can efficiently detect ultrarare mutations resulting from chemical mutagenesis in whole genomes with a sensitivity ~1 × 10−8 mutations per base pair. In this proof‐of‐principle study, we evaluated whether this technique could also detect the on‐ and off‐target mutations generated by a cytosine‐to‐thymine (C>T) BE targeting the LacZ gene in Escherichia coli (E. coli). HiFi sequencing detected on‐target mutant allele fractions ranging from ~7% to ~63%, depending on the single‐guide RNA (sgRNA) used, while no on‐target mutations were detected in controls lacking the BE. The presence of the BE resulted in a ~3‐fold increase in mutation frequencies compared to controls lacking the BE, irrespective of the sgRNA used. These increases were mostly composed of C:G>T:A substitutions distributed throughout the genome. Our results demonstrate that HiFi sequencing can efficiently identify on‐ and off‐target mutations in cell populations that have undergone genome editing.