bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimodality imaging in thoracic aortic diseases: a clinical consensus statement from the European Association of Cardiovascular Imaging and the European Society of Cardiology working group on aorta and peripheral vascular diseases
Authors: Evangelista Artur , Sitges Marta , Jondeau Guillaume , Nijveldt Robin , Pepi Mauro , Cuellar Hug , Pontone Gianluca , Bossone Eduardo , Groenink Maarten , Dweck Marc R , Roos-Hesselink Jolien W , Mazzolai L , van Kimmenade Roland , Aboyans Victor , Rodríguez-Palomares Jose 
Published: March 2023

Abstract
Imaging techniques play a pivotal role in the diagnosis, follow-up, and management of aortic diseases. Multimodality imaging provides complementary and essential information for this evaluation. Echocardiography, computed tomography, cardiovascular magnetic resonance, and nuclear imaging each have strengths and limitations in the assessment of the aorta. This consensus document aims to review the contribution, methodology, and indications of each technique for an adequate management of patients with thoracic aortic diseases. The abdominal aorta will be addressed elsewhere. While this document is exclusively focused on imaging, it is of most importance to highlight that regular imaging follow-up in patients with a diseased aorta is also an opportunity to check the patient’s cardiovascular risk factors and particularly blood pressure control.
Hereditary transthyretin amyloidosis presenting with spontaneous periorbital purpura: a case report
Authors: Jhawar Nikita , Reynolds Jordan , Nakhleh Raouf , Lyle Melissa 
Published: March 2023

AbstractBackgroundAmyloidosis is a systemic disorder of abnormal protein folding and deposition resulting in a range of symptoms including neuropathy, heart failure, renal disease, and dermatologic findings. The two most common types of amyloidosis that affect the heart are transthyretin (ATTR) amyloidosis and light chain (AL) amyloidosis, which vary in clinical presentation. Skin findings such as periorbital purpura are considered more specific for AL amyloidosis. However, there are rare cases of ATTR amyloidosis causing the same dermatologic findings.Case SummaryA 69-year-old female presented for evaluation of amyloidosis after cardiac imaging done at the time of a recent atrial fibrillation ablation showed signs of infiltrative disease. On examination, she had periorbital purpura which she reportedly had for years without receiving a diagnosis, as well as macroglossia with teeth indentation. These exam findings, in addition to her transthoracic echocardiogram showing apical sparing, are typically considered characteristic of AL amyloidosis. Subsequent workup revealed the presence of hereditary ATTR (hATTR) amyloidosis with a heterozygous pathogenic variant in the TTR gene producing the p.Thr80Ala mutation.ConclusionSpontaneous periorbital purpura is thought to be pathognomonic for AL amyloidosis. However, we describe a case of hereditary ATTR amyloidosis with the Thr80Ala TTR genetic variant presenting initially with periorbital purpura, the first case documented in the literature to our knowledge.
A novel breakthrough in wrist-worn transdermal troponin-I-sensor assessment for acute myocardial infarction
Authors: Sengupta Shantanu , Biswal Siddharth , Titus Jitto , Burman Atandra , Reddy Keshav , Fulwani Mahesh C , Khan Aziz , Deshpande Niteen , Shrivastava Smit , Yanamala Naveena , Sengupta Partho P 
Published: March 2023

Abstract

Aims
Clinical differentiation of acute myocardial infarction (MI) from unstable angina and other presentations mimicking acute coronary syndromes (ACS) is critical for implementing time-sensitive interventions and optimizing outcomes. However, the diagnostic steps are dependent on blood draws and laboratory turnaround times. We tested the clinical feasibility of a wrist-worn transdermal infrared spectrophotometric sensor (transdermal-ISS) in clinical practice and assessed the performance of a machine learning algorithm for identifying elevated high-sensitivity cardiac troponin-I (hs-cTnI) levels in patients hospitalized with ACS.

Methods and results
We enrolled 238 patients hospitalized with ACS at five sites. The final diagnosis of MI (with or without ST elevation) and unstable angina was adjudicated using electrocardiography (ECG), cardiac troponin (cTn) test, echocardiography (regional wall motion abnormality), or coronary angiography. A transdermal-ISS–derived deep learning model was trained (three sites) and externally validated with hs-cTnI (one site) and echocardiography and angiography (two sites), respectively. The transdermal-ISS model predicted elevated hs-cTnI levels with areas under the receiver operator characteristics of 0.90 [95% confidence interval (CI), 0.84–0.94; sensitivity, 0.86; and specificity, 0.82] and 0.92 (95% CI, 0.80–0.98; sensitivity, 0.94; and specificity, 0.64), for internal and external validation cohorts, respectively. In addition, the model predictions were associated with regional wall motion abnormalities [odds ratio (OR), 3.37; CI, 1.02–11.15; P = 0.046] and significant coronary stenosis (OR, 4.69; CI, 1.27–17.26; P = 0.019).

Conclusion
A wrist-worn transdermal-ISS is clinically feasible for rapid, bloodless prediction of elevated hs-cTnI levels in real-world settings. It may have a role in establishing a point-of-care biomarker diagnosis of MI and impact triaging patients with suspected ACS.
Prospective relationship between occupational physical activity and risk of ischaemic heart disease: are men and women differently affected?
Authors: Allesøe Karen , Aadahl Mette , Jacobsen Rikke Kart , Kårhus Line Lund , Mortensen Ole Steen , Korshøj Mette 
Published: March 2023

Abstract

Aims
High occupational physical activity (OPA) seems to increase risk of cardiovascular diseases among men. However, findings are mixed, and it is not known if women are differently affected. Therefore, the aim of this study is to investigate the relationship between OPA and risk for ischaemic heart disease (IHD), and whether it differs across sex.

Methods and results
This prospective cohort study was based on 1399 women and 1706 men, aged 30–61 years, participating in the Danish Monica 1 study in 1982–84, actively employed, without prior IHD and answering an OPA question. The information on incidence of IHD, before and during the 34-years follow-up, was retrieved by individual linkage to the Danish National Patient Registry. Cox proportional hazards models were used to investigate the association between OPA and IHD. Compared to women with sedentary work, women in all other OPA categories had lower hazard ratio (HR) for IHD. Among men, the risk of IHD was 22% higher among those with light OPA, and 42% and 46% higher among those with moderate OPA with some lifting or strenuous work with heavy lifting, respectively, compared to men with sedentary OPA. Compared to women with sedentary work, HR for IHD was higher among men in all OPA categories. There was statistically significant interaction between OPA and sex.

Conclusion
Demanding or strenuous OPA seems to be a risk factor for IHD among men, whereas a higher level of OPA seems to protect women from IHD. This emphasizes the importance of taking sex differences into account in studies of health effects of OPA.
Aging and Economic Preferences: Cumulative Meta-Analyses of Age Differences in Risk, Time, Social, and Effort Preferences
Authors: Bagaïni Alexandra , Liu Yunrui , Bajrami Arzie , Son Gayoung , Tisdall Loreen , Mata Rui 
Published: March 2023

Abstract

Objectives
Several theories predict changes in individuals’ economic preferences across the life span. To test these theories and provide a historical overview of this literature, we conducted meta-analyses on age differences in risk, time, social, and effort preferences as assessed by behavioral measures.

Methods
We conducted separate meta-analyses and cumulative meta-analyses on the association between age and risk, time, social, and effort preferences. We also conducted analyses of historical trends in sample sizes and citation patterns for each economic preference.

Results
The meta-analyses identified overall no significant effects of age for risk (r = −0.02, 95% CI [−0.06, 0.02], n = 39,832) and effort preferences (r = 0.24, 95% CI [−0.05, 0.52], n = 571), but significant effects of age for time (r = −0.04, 95% CI [−0.07, −0.01], n = 115,496) and social preferences (r = 0.11, 95% CI [0.01, 0.21], n = 2,997), suggesting increased patience and altruism with age, respectively. Equivalence tests, which compare these effects to practically important ones (i.e., r = |0.1|), however, suggest that all effects are of trivial significance. The analyses of temporal trends suggest that the magnitude of effects and sample sizes have not changed significantly over time, nor do they dramatically affect the extent that articles are cited.

Discussion
Overall, our results contrast with theories of aging that propose general age effects for risk and effort preferences, yet provide some but tenuous support for those suggesting age-related changes in time and social preferences. We discuss implications for theory development as well as future empirical work on economic preferences.
Using Item Response Times in Online Questionnaires to Detect Mild Cognitive Impairment
Authors: Schneider Stefan , Junghaenel Doertes U , Meijer Erik , Stone Arthur A , Orriens Bart , Jin Haomiao , Zelinski Elizabeth M , Lee Pey-Jiuan , Hernandez Raymond , Kapteyn Arie 
Published: March 2023

Abstract

Objectives
With the increase in web-based data collection, response times (RTs) for survey items have become a readily available byproduct in most online studies. We examined whether RTs in online questionnaires can prospectively discriminate between cognitively normal respondents and those with cognitive impairment, no dementia (CIND).

Method
Participants were 943 members of a nationally representative internet panel, aged 50 and older. We analyzed RTs that were passively recorded as paradata for 37 surveys (1,053 items) administered online over 6.5 years. A multilevel location-scale model derived 3 RT parameters for each survey: (1) a respondent’s average RT and 2 components of intraindividual RT variability addressing (2) systematic RT adjustments and (3) unsystematic RT fluctuations. CIND status was determined at the end of the 6.5-year period.

Results
All 3 RT parameters were significantly associated with CIND, with a combined predictive accuracy of area under the receiver-operating characteristic curve = 0.74. Slower average RTs, smaller systematic RT adjustments, and greater unsystematic RT fluctuations prospectively predicted a greater likelihood of CIND over periods of up to 6.5, 4.5, and 1.5 years, respectively.

Discussion
RTs for survey items are a potential early indicator of CIND, which may enhance analyses of predictors, correlates, and consequences of cognitive impairment in online survey research.
Geographic Patterns of Dementia in the United States: Variation by Place of Residence, Place of Birth, and Subpopulation
Authors: Zacher Meghan , Brady Samantha , Short Susan E 
Published: March 2023

AbstractObjectivesThe prevalence of dementia varies geographically in the United States. However, the extent to which this variation reflects contemporary place-based experiences versus embodied exposures from earlier in the life course remains unclear, and little is known regarding the intersection of place and subpopulation. This study, therefore, evaluates whether and how risk for assessed dementia varies by place of residence and birth, overall and by race/ethnicity and education.MethodsWe pool data from the 2000 to 2016 waves of the Health and Retirement Study, a nationally representative panel survey of older U.S. adults (n = 96,848 observations). We estimate the standardized prevalence of dementia by Census division of residence and birth. We then fit logistic regression models of dementia on region of residence and birth, adjusting for sociodemographic characteristics, and examine interactions between region and subpopulation.ResultsThe standardized prevalence of dementia ranges from 7.1% to 13.6% by division of residence and from 6.6% to 14.7% by division of birth, with rates highest throughout the South and lowest in the Northeast and Midwest. In models accounting for region of residence, region of birth, and sociodemographic covariates, Southern birth remains significantly associated with dementia. Adverse relationships between Southern residence or birth and dementia are generally largest for Black and less-educated older adults. As a result, sociodemographic disparities in predicted probabilities of dementia are largest for those residing or born in the South.DiscussionThe sociospatial patterning of dementia suggests its development is a lifelong process involving cumulated and heterogeneous lived experiences embedded in place.
What is a vishwaguru? Indian civilizational pedagogy as a transformative global imperative
Authors: de Estrada Kate Sullivan 
Published: March 2023

Abstract
Ambitions for India to enact the role of vishwaguru or ‘world teacher’ are a conspicuous feature of foreign policy discourse under contemporary Hindu nationalist rule in India. This discourse, and India's foreign-policy practice, engage the international realm with a puzzling intensity given Hindu nationalism's inward-looking and exclusionary emphasis on majoritarian cultural unity. In this article, I leverage International Relations scholarship on social closure, international order and recognition struggles to examine the historical lineages and recent articulations of nineteenth-century religious reformist ideas about India's world mission and spiritual superiority. I argue that different Indian civilizational imaginaries across time produce a pedagogical imperative, aimed at the transformation of global social hierarchies. Centred on a quest to assert social superiority and remake the terms of recognition, any given vishwaguru project nonetheless relies on international recognition. The recent domestic and diasporic appeal of Hindu nationalist foreign policy stems from how it appears to intervene to rectify the longstanding misrecognition of India. In this context, western liberal states' instrumental recognition of India as a democratic partner and defender of liberal order in the face of a ‘China challenge’ works to endorse and bolster the vishwaguru project of India's current domestic political moment.
From Hinduism to Hindutva: civilizational internationalism and UNESCO
Authors: Singh Rani , Winter Tim 
Published: March 2023

Abstract
This article considers civilizational politics at the interface between nationalism and internationalism. It does this by focusing on some key trends in India's engagements with UNESCO and its flagship conventions for culture. The article builds on existing scholarship regarding the political appropriation of key religious and heritage sites within India by critically examining how Hinduism is presented to UNESCO and other organizations as a religious and civilizational heritage for global recognition and endorsement. We argue that UNESCO's programmes and conventions are being co-opted via a rewriting of history and in the creation of heritage imaginaries of a Hindu nation. From there, the discussion extends previous critiques regarding the conjoining of Hinduism to a Harappan civilization heritage by showing how this geographically extends outwards via a programme of Indian Ocean diplomacy conceived around environmental and historical connectivities. In pulling these various threads together, the article demonstrates the ways in which Hindu civilizational discourses circulate at the international level in seemingly benign and banal ways, and, yet, simultaneously advance the domestic cultural politics now familiar to the Hindutva movement.
Disciplining India: paternalism, neo-liberalism and Hindutva civilizationalism
Authors: Chacko Priya 
Published: March 2023

Abstract
Policy hybrids, which combine marketizing and liberalizing reforms with social welfare programmes and state support to boost domestic production, are fast becoming the norm globally. How are neo-liberal and national-developmentalist agendas reconciled as governing practices, and what are their national and international outcomes and implications? This article focuses on the understudied case of India, arguing that a paternalist political rationality, which melds paternalist logics in neo-liberalism and the government's Hindutva civilizationalist politics, underpins its flagship economic policy, the Atmanirbhar Bharat Abhiyan (Self-reliant India Mission). This policy, through production-linked incentives, aims to boost Indian manufacturing. India has benefited from a global push to diversify supply chains and forge new geopolitical partnerships, such as the Quad, to undermine China's manufacturing dominance and geopolitical assertiveness. Yet, its current approach consolidates the dominance of large firms, producing an elitist political economy, and does not address structural weaknesses through public investment in areas like research and education. This has implications for India's development, global trade and geopolitics. These arguments are made by identifying the paternalist logics in the theories and practices of neo-liberalism, and in Hindutva civilizationalist politics; assessing the aims of the Atmanirbhar Bharat Abhiyan as elaborated by government officials; and evaluating the early outcomes of production-linked incentive schemes.
What if? Counterfactual Trump and the western response to the war in Ukraine
Authors: Kaarbo Juliet , Oppermann Kai , Beasley Ryan K 
Published: March 2023

Abstract
Because of his personality, had Donald Trump won the 2020 election the remarkable and unexpected united response by NATO allies to the February 2022 Russian invasion of Ukraine would not have happened. Relying on leader personality research in foreign policy, we demonstrate this by using the counterfactual method of analysis. Specifying key differences between Biden's and Trump's personalities in terms of their experiences, traits and beliefs, we explicitly show that president Trump would have been very unlikely to share US intelligence, rally NATO allies in support of Ukraine or challenge Vladimir Putin. In contrast, these responses fit very well with Joe Biden's personality. We first present counterfactual analysis as a method before comparing Biden and Trump along personality characteristics known to significantly influence foreign-policy decisions. Through our case-study, we demonstrate the value of using systematic and theoretically grounded counterfactual methods for assessing the importance of individual differences between leaders and emphasizing their impact on international affairs.
A Longitudinal Study of Self-Disclosure in Human–Chatbot Relationships
Authors: Skjuve Marita , Følstad Asbjørn , Brandtzæg Petter Bae 
Published: March 2023

Abstract
Self-disclosure in human–chatbot relationship (HCR) formation has attracted substantial interest. According to social penetration theory, self-disclosure varies in breadth and depth and is influenced by perceived rewards and costs. While previous research has addressed self-disclosure in the context of chatbots, little is known about users' qualitative understanding of such self-disclosure and how self-disclosure develops in HCR. To close this gap, we conducted a 12-week qualitative longitudinal study (n = 28) with biweekly questionnaire-based check-ins. Our results show that while HCRs display substantial conversational breadth, with topics spanning from emotional issues to everyday activities, this may be reduced as the HCR matures. Our results also motivate a nuanced understanding of conversational depth, where even conversations about daily activities or play and fantasy can be experienced as personal or intimate. Finally, our analysis demonstrates that conversational depth can develop in at least four ways, influenced by perceived rewards and costs. Theoretical and practical implications are discussed.
Poverty and Frailty Are Not Related to Each Other With Regard to Outcomes in Middle-Aged and Older Patients with Burn Injuries
Authors: Wallace David , Sloan Keturah , Williams Deborah , Heard Jason , Sen Soman , Palmieri Tina , Greenhalgh David , Romanowski Kathleen 
Published: March 2023

Abstract
The purpose of this study was to determine the relationship between frailty and poverty in burn patients ≥50 years old, and their association with patient outcomes. This was a single-center retrospective chart review from 2009 to 2018 of patients ≥50 years old admitted with acute burn injuries. Frailty was assigned using the Canadian Study of Health and Aging Clinical Frailty Scale. Poverty was defined as a patient from a zip code that had &gt;20% of people living in poverty. The relationship between frailty and poverty, as well as each variable independently on mortality, length of stay (LOS), and disposition location, was examined. Of 953 patients, the median age was 61 years, 70.8% were male, and the median total body surface area burn was 6.6%. Upon admission, 26.4% and 35.2% of patients were frail and from impoverished neighborhoods, respectively. The mortality rate was 8.8%. Univariate analysis demonstrated that nonsurvivors had significantly higher chances of living in poverty (P = .02) and were more likely to be frail compared to survivors. There was no significant correlation between poverty and frailty (P = .08). Multivariate logistic regression confirmed the relationship between lack of poverty and mortality (OR .47, 95% CI 0.25–0.89) and frailty and mortality (OR 1.62, 95% CI 1.24–2.12). Neither poverty (P = .26) nor frailty (P = .52) was associated with LOS. Both poverty and frailty were associated with a patient’s discharge location (P = .03; P &lt; .0001). Poverty and frailty each independently predict mortality and discharge destination in burn patients ≥50, but they are not associated with LOS nor each other.
Race and Ethnicity Influences Outcomes of Adult Burn Patients
Authors: DiPaolo Nicola , Hulsebos Ian F , Yu Jeremy , Gillenwater Timothy Justin , Yenikomshian Haig A 
Published: March 2023

Abstract
Outcomes of burn survivors is a growing field of interest; however, there is little data comparing the outcomes of burn survivors by ethnicity. This study seeks to identify any inequities in burn outcomes by racial and ethnic groups. A retrospective chart review of an ABA Certified burn center at a large urban safety net hospital identified adult inpatient admissions from 2015 to 2019. A total of 1142 patients were categorized by primary ethnicity: 142 black or African American, 72 Asian, 479 Hispanic or Latino, 90 white, 215 other, and 144 patients whose race or ethnicity was unrecorded. Multivariable analyses evaluated the relationship between race and ethnicity and outcomes. Covariate confounders were controlled by adjustment of demographic, social, and prehospital clinical factors to isolate differences that might not be explained by other factors. After controlling for covariates, black patients had 29% longer hospital stays (P = .043). Hispanic patients were more likely to be discharged to home or to hospice care (P = .005). Hispanic ethnicity was associated with a 44% decrease in the odds of discharge to acute care, inpatient rehabilitation, or a ward outside the burn unit (P = .022). Black and Hispanic patients had a higher relative chance of having publicly assisted insurance, versus private insurance, than their white counterparts (P = .041, P = .011 respectively). The causes of these inequities are indeterminate. They may stem from socioeconomic status not entirely accounted for, ethnic differences in comorbidity related to stressors, or inequity in health care delivery.