bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hashimoto’s thyroiditis increases the risk of new-onset systemic lupus erythematosus: a nationwide population-based cohort study
Authors: Lin Hong-Ci , Chang Hsu-Min , Hung Yao-Min , Chang Renin , Chen Hsin-Hua , Wei James Cheng-Chung 
Published: February 2023

Abstract
Background
Previous studies have shown systemic lupus erythematosus (SLE) patients had a significantly higher prevalence of thyroid diseases and hypothyroidism than matched controls, and some case reports showed SLE may occur after Hashimoto’s thyroiditis (HT).

Objective
This study aimed to investigate the subsequent risk of SLE in patients with HT.

Methods
In this retrospective cohort study done by the Taiwan National Health Insurance Research Database, the HT group (exposure group) and the non-HT group (comparator group) were propensity score matched at a ratio of 1:2 by demographic data, comorbidities, medications, and the index date. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Several sensitivity analyses were done for cross-validation of our findings.

Results
We identified 15,512 HT patients and matched 31,024 individuals. The incidence rate ratio of SLE was 3.58 (95% CI, 2.43–5.28; p < 0.01). Several sensitivity analyses show adjusted hazard ratio (aHR) (CIs) of 4.35 (3.28–5.76), 4.39 (3.31–5.82), 5.11 (3.75–6.98), and 4.70 (3.46–6.38), consistent with the results of the main model.

Conclusion
Our study showed an increased risk of SLE in the HT group after adjustment for baseline characteristics, comorbidities, and medical confounders compared with the reference group.
Cardiac tamponade during venoarterial extracorporeal membrane oxygenation: a case report
Authors: Adriaansen E. J. M. , Hermens J. A. J. , Broome M. , Pladet L. , Dubois E. , Donker D. W. , Meuwese C. L. 
Published: February 2023

Abstract
Background
Cardiac tamponade may present with very different signs and clinical consequences in patients who are supported with venoarterial extracorporeal membrane oxygenation. Failure to recognize cardiac tamponade in this setting can cause failure to wean from venoarterial extracorporeal membrane oxygenation, and even lead to death.

Case presentation
We present a 44-year-old Caucasian female in whom cardiac tamponade manifested as venoarterial extracorporeal membrane oxygenation weaning failure. After discovering the contribution of cardiac tamponade, it was possible to wean the patient from venoarterial extracorporeal membrane oxygenation support. No clear signs of cardiac tamponade had existed beforehand.

Conclusions
The diagnosis of cardiac tamponade can be very challenging in venoarterial extracorporeal membrane oxygenation supported patients due to (patho)physiological particularities related to the parallel blood flow.
Triple-tyrosine kinase inhibition by BIBF1000 attenuates airway and pulmonary arterial remodeling following chronic allergen challenges in mice
Authors: Gurusamy Malarvizhi , Nasseri Saeed , Rampa Dileep Reddy , Feng Huiying , Lee Dongwon , Pekcec Anton , Doods Henri , Wu Dongmei 
Published: February 2023

Abstract
Background
Airway remodeling is an important pathological feature of chronic airway diseases, which leads to a progressive decline in lung function. The present study examined the anti-remodeling and anti- inflammatory effect of BIBF1000, a triple-tyrosine kinase inhibitor that targets VEGF, PDGF, and FGF receptor signaling in a mouse model of repeated ovalbumin (OVA) challenges.

Methods
Female Balb-c mice were immunized intraperitoneally on days 0 and 12 with 50 µg ovalbumin plus 1 mg of Al(OH)3 in 200 μl saline. Intranasal OVA challenges (20 µg/50 µl in PBS) were administered on days 26, 29, and 31, and were repeated twice a week for 3 months. Animals received vehicle or BIBF1000 (25 mg/kg, b.i.d.) through gavage from day 26 to the end of fourth month. On day 120, bronchoalveolar lavage (BAL) and lung tissue were collected for biochemical and immunohistological analysis.

Results
Compared to vehicle controls, treatment with BIBF1000 reduced the numbers of BAL eosinophils, macrophages, neutrophils, and lymphocytes by 70.0%, 57.9%, 47.5%, and 63.0%, respectively, and reduced IL-5 and IL-13 in BAL. Treatment with BIBF1000 reduced airway mucus secretion, peribronchial fibrosis, small airway, and pulmonary arterial wall thickness, compared to vehicle controls. Furthermore, treatment with BIBF1000 also reduced the expression of inflammatory mediators (TNF-α, IL-1β, IL-5, IL-13, MMP-2, MMP-9, COX-2, and iNOS) and inhibited ERK and AKT phosphorylation.

Conclusions
The protective effect afforded by triple-tyrosine kinase inhibition with BIBF1000 in reducing allergen-induced airway and arterial remodeling was associated with down-regulation of inflammatory mediators, as well as inhibition of ERK and AKT signaling pathways.
Not all engaged students are alike: patterns of engagement and burnout among elementary students using a person-centered approach
Authors: Yang Dong , Cai Zhenyu , Wang Chaoyi , Zhang Chen , Chen Peng , Huang Ronghuai 
Published: February 2023

AbstractDue to its potential to address low achievement, high dropout rates, and misbehavior among students, school engagement has become an important topic in contemporary developmental psychology and educational research. Although there is a wealth of literature on the causes and effects of student engagement, the current understanding of how student engagement varies in response to different teaching styles is limited. This study examined the engagement and burnout profiles of elementary school pupils (N = 798; 51% females; Mage = 11.54, SDage = 0.72) and the interactions between those profiles, students’ characteristics and their perceptions of instructional behaviors (e.g., supporting criticism, suppressing criticism & independent viewpoints, intruding). Latent profile analysis revealed five types of profiles: moderately burned out, slightly burned out, moderately engaged, highly engaged, and highly burned out. Follow-up logistic regression analysis found that students clustered into engagement groups were likely to report higher autonomy support from teachers, especially when teachers permit criticism and independent thinking from students. In contrast, students clustered into burned out profiles were more likely to rate teacher strategies as autonomy suppressive. This became more obvious when instructors imposed meaningless and uninteresting activities. Taken together, this study indicated that autonomy-supportive teaching behaviors are pivotal in understanding student engagement and school burnout. The significance of the findings was addressed, along with implications and limitations.
Including the child’s voice in research from a longitudinal birth cohort: insights from the ROLO young person’s advisory group
Authors: Delahunt Anna , Callanan Sophie , Killeen Sarah Louise , McDonnell Ciara M. , McAuliffe Fionnuala M. 
Published: February 2023

Abstract
Background
Public and patient involvement (PPI) through Young Person’s Advisory Groups (YPAG) enables children to provide guidance and insight into research activities. PPI is an important characteristic of research, however, to date, most collaboration has been with adults. Also, few YPAGs have been established within the Irish setting. The ROLO (Randomised cOntrol trial of a LOw glycaemic index diet in pregnancy to prevent macrosomia) YPAG was established in July 2020 to identify the research priorities of a group of healthy Irish children who are part of a longitudinal birth cohort. We aimed to describe this process and the key insights to date.

Methods
The ROLO study is a longitudinal birth cohort which has followed-up mother–child dyads at multiple timepoints over 10 years. Mothers actively involved in the study were contacted by the research team to invite their ROLO child and older sibling to participate in the YPAG. Meetings were conducted virtually between July 2020 and February 2022. Researchers encouraged free expression of views amongst the children regarding their research interests. Meetings were recorded, transcribed verbatim and analysed for themes based on the topics most frequently discussed and considered important to participants.

Results
In all, seven ROLO children and six older siblings attended four ROLO YPAG meetings. Participants were aged between nine to fifteen years old. Four key themes were identified; study children viewed their identity as part of a longitudinal birth cohort as positive and unique; study children considered the fitness test and body measurements as fun aspects related to their participation; all children considered the impact and use of social media as an important form of communication; and all participants expressed interest in attaining new health-related information and learning opportunities. Children suggested topics such as mental health, future viruses, organ transplants, cancer, and the effect of technology and chemicals on the body were important for future research.

Conclusion
The ROLO YPAG offers promising scope for continued collaboration. The themes identified from the meetings contribute to a gap in the literature which will guide future research activities, particularly with children, in view of study design, relevance, and by communication strategies.
Trial Details: ISRCTN54392969 registered at www.isrctn.com.
Drowsiness following ondansetron given the day after general anesthesia for postoperative nausea: a pediatric case report
Authors: Furuta Machiko , Miyasaka Kiyoyuki , Suzuki Yasuyuki 
Published: February 2023

Abstract
Background
Ondansetron is an antiemetic drug that is useful not only for prevention but also for the treatment of postoperative nausea and vomiting (PONV). We report a rare case of drowsiness in a child after using ondansetron for nausea on the day after general anesthesia.

Case presentation
A 5-year-old boy underwent circumcision under general anesthesia and suffered from postoperative nausea and vomiting. He was administered 0.1mg/kg of ondansetron in the PACU and 23 h later on the day after surgery. After the second dose, he acutely exhibited drowsiness which resolved in 3 h. He was discharged to home later on the same day. He was not given any other drugs at the time, and the drowsiness was thought to be directly attributable to ondansetron, though the exact mechanism was unknown.

Conclusions
When drowsiness or other cognitive symptoms are observed after administration of ondansetron, it must be considered and managed as a possible side effect.
Right ventricle speckle tracking in bronchopulmonary dysplasia: one-year follow-up
Authors: Clavero-Adell Marcos , Palanca-Arias Daniel , López-Ramón Marta , Jimenez-Montañés Lorenzo , Serrano-Viñuales Itziar , Rite-Gracia Segundo , Ayerza-Casas Ariadna 
Published: February 2023

Abstract
Background
Bronchopulmonary dysplasia (BPD) is still a major concern in preterm infants and adequate screening methods for secondary right ventricle (RV) failure are needed. Early detection could be aided by taking measurements of RV deformation using speckle tracking echocardiography. A prospective longitudinal study was carried out over 28 months at a tertiary care pediatric cardiology center. Preterm infants < 32 weeks gestational age (GA) were eligible for the study. Enrolled patients were separated in two groups: NO-BPD or BPD. At three timepoints over the first year of life, echocardiogram measurements were performed. Right ventricle strain was studied using speckle tracking analysis and compared to conventional function parameters.

Results
Fifty patients were enrolled in the study, 22 in the NO-BPD group and 28 in the BPD group. RV strain showed no statistical differences between groups. However, the BPD group showed worse RV function than the NO-BPD group, using speckle tracking analysis and other conventional parameters. During the study follow-up, an improvement trend is shown in RV strain.

Conclusions
RV longitudinal strain and strain rate derived by speckle tracking is feasible in preterm infants. Although there seems to be a good correlation between RV strain and BPD severity, the results of this study were not conclusive. More studies should be carried out to investigate the optimum echocardiographic screening model of RV dysfunction in BPD patients.
An alternative anatomical classification for carotid bifurcation and impact on outcome of carotid endarterectomy: a multicenter study
Authors: Kazantsev Anton N. , Korotkikh Alexander V. , Lider Roman Yu. , Lebedev Oleg V. , Sirotkin Alexey A. , Palagin Petr D. , Mukhtorov Otabek Sh. , Shmatov Dmitriy V. , Sergey Artyukhov , Kazantseva Elizaveta G. , Bagdavadze Goderzi Sh. , Wang Shuowen , Roshkovskaya Ludmila V. , Khetagurov Mikhail A. , Unguryan Vladimir M. , Chernyavin Maxim P. , Nonye Okenu Gloria , Belov Yuri V. 
Published: February 2023

Abstract
Background
The present multicenter retrospective study included 7148 patients who underwent carotid endarterectomy (CEA) between 2010 and 2021. Based on the results of angiography (AG)/multislice computed tomography (MSCT) angiography, 3 types of carotid bifurcation were identified depending on the projection of the carotid sinus to the cervical vertebrae: type I (high)—from the upper edge of the body of the II cervical vertebra to the lower edge of intervertebral disc located between III and IV cervical vertebrae; type II (medium)—from the upper edge of the body of the IV cervical vertebra to the lower edge of the body of the V cervical vertebra; and type III (low)—from the upper edge of the intervertebral disc located between the V and VI cervical vertebrae to the lower edge of the body of the VII cervical vertebra.

Purpose of the study
To develop a new classification of the types (high, medium, low) of carotid bifurcations (based on the level of cervical vertebrae) with analysis of the results of CEA depending on the type.

Results
The largest number of ischemic strokes (n = 15; 1.1%; p = 0.0001) was found in type I (high) bifurcation of the carotid artery. The majority of bleedings of type 3b and higher according to the BARC scale with the formation of acute hematomas in the intervention area (n = 14; 1.2%; p = 0.0029) were recorded in type III carotid bifurcation (low).

Conclusions
Type II (medium) carotid bifurcation may be the most preferred for CEA.
Stent-Assisted Coil Embolization Versus Flow-Diverting Stent in Unruptured Vertebral Artery Dissecting Aneurysms: Efficacy and Safety Comparison
Authors: Oh Han San , Bae Jin Woo , Hong Chang-eui , Kim Kang Min , Yoo Dong Hyun , Kang Hyun-Seung , Cho Young Dae 
Published: February 2023

BACKGROUND:
Reconstructive strategies for unruptured vertebral artery dissecting aneurysms (VADAs) have increasingly relied on newly developed endovascular devices. However, their clinical performance metrics are seldom reported.

OBJECTIVE:
To compare stent-assisted coil embolization (SACE) and flow-diverting stent (FDS) deployment as treatments for unruptured VADAs, focusing on efficacy and safety.

METHODS:
A total of 72 VADAs were submitted to SACE (n = 48) or FDS (n = 24) between April 2009 and September 2021. We reviewed medical records and radiological data to assess efficacy and safety outcomes by method, building an inverse probability of treatment-weighted (IPTW) logistic regression model and conducting survival analyses.

RESULTS:
Ultimately, 24 aneurysms (33.3%) showed signs of recanalization (major, 14; minor, 10) at 6-month follow-up. Initially determined 6-month rates of overall (SACE, 31.2%; FDS, 41.7%) and major (SACE, 20.8%; FDS, 16.7%) recanalization did not differ significantly by modality; but in the IPTW logistic regression model, adjusted for aneurysm morphology, major recanalization at 6 months was lower for the FDS (vs SACE) subset (odds ratio = 0.196; P = .027). Likewise, the cumulative rate of major recanalization was more favorable for the FDS (vs SACE) subset (hazard ratio = 0.291; P = .048) in IPTW Cox proportional hazards model adjusted for aneurysm morphology. Modality-based assessments of procedural and delayed complications were similar.

CONCLUSION:
Both reconstructive VADA interventions are safe and effective by adjusting treatment modality depending on the angioanatomic configuration. However, follow-up data after treatment proved more favorable for FDS deployment than for SACE in limiting major recanalization. Case-controlled studies of more sizeable cohorts are needed for corroboration.
Size-Dependent Oscillation in Optical Spectra from Fly Ash Cenospheres: Particle Sizing Using Darkfield Hyperspectral Interferometry
Authors: Beach James M , Kryuchkova Marina , Fakhrullin Ramil , Mazurova Kristina , Stavitskaya Anna , Cheatham Byron J , Fakhrullin Rawil 
Published: February 2023

Abstract
Fly ash by-products are emerging biocompatible fillers for a number of construction materials. The value of fly ash as a filler is higher if the content of hollow cenospheres is increased. Here we describe a new method for detection and sizing of fly ash spheres based on darkfield microscopy with hyperspectral image capture to perform white light interferometry. Our method is cost-effective and can provide rapid means for evaluating cenosphere content during the enrichment process. We show that fly ash cenospheres produce a strong oscillation over wavelength in optical recordings. The phenomenon is easiest to observe using microscope imaging techniques that preserve both spatial and spectral information. Frequency is observed to increase in direct proportion to the sphere diameter. The oscillation appears in light recorded from any focal plane on the sphere which indicates that the entire sphere is involved in sustaining the signal, making the detection of cenospheres of different size and displacement within a recording volume productive. There is no oscillation from nonspherical particles of fly ash or other material, so this detection method is highly selective for the cenospheres.
Learning in Networks: An Experiment on Large Networks with Real-World Features
Authors: Choi Syngjoo , Goyal Sanjeev , Moisan Frederic , To Yu Yang Tony 
Published: February 2023

Subjects observe a private signal and make an initial guess; they then observe their neighbors’ guesses, update their own guess, and so forth. We study learning dynamics in three large-scale networks capturing features of real-world social networks: Erdös–Rényi, Stochastic Block (reflecting network homophily), and Royal Family (that accommodates both highly connected celebrities and local interactions). We find that the Royal Family network is more likely to sustain incorrect consensus and that the Stochastic Block network is more likely to persist with diverse beliefs. These patterns are consistent with the predictions of DeGroot updating. It lends support to the notion that the use of simple heuristics in information aggregation is prevalent in large and complex networks. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: The authors thank the Keynes Fund (University of Cambridge), the Creative-Pioneering Researchers Program (Seoul National University), and C-BID (NYUAD) for financial support. Supplemental Material: The data files and e-companion are available at https://doi.org/10.1287/mnsc.2023.4680 .
Micro:bit Hero: Using MakeCode to Replicate Popular Songs
Authors: Johnson Brian 
Published: February 2023

This lesson opens with an introduction of how to program the Micro:bit using block code to play music using the piano keyboard embedded in the music section of Micro:bit Make Code. In this lesson, students explore how to make music using this feature and learn how to program the Micro:bit using MakeCode to incorporate rests and different notes (quarter, half, and full) to replicate nursery rhymes or popular songs. The lesson concludes with a discussion of the challenges/limitations of coding the Micro:bit to play music. Students also shared their musical creations with their peers through a “Name that Tune” game where they attempted to guess which popular song or nursery rhyme their peers had replicated in MakeCode.
Time: 30-45 minutes
Dual-beam polarimeter based on nonachromatic wave plates with high polarimetric efficiency over a broad band
Authors: Wan Fan , Zhong Yue , Qu Zhongquan , Xu Zhi , Zhang Hui 
Published: February 2023

The design
and
test
of a dual-beam polarimeter to
be applied to the Fiber Array Solar Optical Telescope of the second
generation is described. The polarimeter consists of a half and a
quarter nonachromatic wave plate, followed by a polarizing beam
splitter as a polarization analyzer. It has the features of simple
structure, stable operation, and temperature insensitivity. The most
outstanding feature of the polarimeter is that a combination of
commercial nonachromatic wave plates is used as a modulator to have
the high polarimetric efficiency of the Stokes polarization parameters
over 500–900 nm; the efficiency balance among the linear and circular
polarization parameters is also taken into account. In order to see
the stability and reliability of this polarimeter, we perform the
actual measurement of the polarimetric efficiencies of the assembling
polarimeter in the laboratory. It is found that the lowest linear
polarimetric efficiency is over 0.46, the lowest circular polarimetric
efficiency is above 0.47, and the total polarimetric efficiency is
greater than 0.93 over 500–900 nm. The measured results are basically
consistent with the theoretical design. Thus, the polarimeter
guarantees observers to choose freely spectral lines, formed in
different layers of the solar atmosphere. It can be concluded that
such a dual-beam polarimeter based on nonachromatic wave plates has
excellent performance and can be extensively applied in astronomical
measurement.
Key factors influencing public health students and curricula in India: Recommendations from a mixed methods analysis
Authors: Schleiff Meike , Brahmbhatt Haley , Banerjee Preetika , Reddy Megha , Miller Emily , Majumdar Piyusha , Mangal D. K. , Gupta Shiv Dutt , Zodpey Sanjay , Shet Anita 
Published: February 2023

Background
Building on a distinguished history of community medicine training, public health programs have been expanding in India in recent years. The COVID-19 pandemic has brought additional attention to the importance of public health programs and the need for a strong workforce. This paper aims to assess the current capacity for public health education and training in India and provide recommendations for improved approaches to meet current and future public health needs.

Methods
We conducted a desk review of public health training programs via extensive internet searches, literature reviews, and expert faculty consultations. Among those programs, we purposively selected faculty members to participate in in-depth interviews. We developed summary statistics based on the desk review. For qualitative analysis, we utilized a combination of deductive and inductive coding to identify key themes and systematically reviewed the strengths and weaknesses of each theme.

Results
The desk review captured 59 institutions offering public health training across India. The majority of training programs were graduate level degrees including Master of Public Health and Master of Science degrees. Key factors impacting these programs included collaborations, mentorship, curriculum standardization, tuition and funding, and student demand for public health education and careers. Collaborations and mentorship were highly valued but varied in quality across institutions. Curricula lacked standardization but also contained substantial flexibility and innovation as a result. Public sector programs were perceived to be affordable though fees and stipends varied across institutions. Further development of career opportunities in public health is needed.

Conclusion
Public health education and training in India have a strong foothold. There are numerous opportunities for continued expansion and strengthening of this field, to support a robust multi-disciplinary public health workforce that will contribute towards achieving the sustainable development goals.