bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of climate change and vector borne diseases in South Asia: a systematic review protocol
Authors: Khatoon Sajda , Bhattacharya Paramita , Karuveettil Vineetha , Mahapatra Biswajit , Mathew Supriya , Thakur Rishu , Jankiram Chandrashekar , Mukherjee Nirmalya , John Denny 
Published: August 2023

Abstract
Objective
The objective of this review is to provide consolidated evidence on the occurrence of vector-borne diseases is associated with climate change in South Asia.
Introduction:
Vector Borne Diseases (VBDs) are parasitic, viral, and bacterial ailments transmitted to humans by vectors. Vectors are organisms capable of transmitting infectious pathogens between humans or between humans and animals. Vector Borne Diseases (VBDs) are one of the climate-sensitive communicable diseases identified by the Intergovernmental Panel on Climate Change. Climate change is a cause for concern since it can have direct and indirect effects on the epidemiology of VBDs. South Asian countries are highly vulnerable to climate change according to the ND-GAIN Country Index.
Inclusion criteria:
This systematic review will include the studies on the population residing in eight South Asian countries of India, Pakistan, Bangladesh, Sri Lanka, Bhutan, Nepal, Maldives and Afghanistan related to vector borne diseases; namely, malaria, dengue, chikungunya, Japanese encephalitis, lymphatic filariasis, Leishmaniasis or kala-azar and schistosomiasis in South Asia and their association with climate change aspects such as increased temperatures, varied precipitation, humidity levels as outcomes.
Methods
A preliminary search of PubMed will be conducted using MESH terms to find relevant papers on Vector Borne Disease, climate change, South Asia. A three-step search approach will be then implemented, including a preliminary limited search, using textual terms in titles and abstracts, and index terms. The databases to be searched for published papers will include Embase (Elsevier), MEDLINE (PubMed), Scopus (Elsevier), Web of Science (Clarivate), and Google Scholar. Grey literature, such as Ministry of Health and Family Welfare's technical reports, master's and doctoral dissertations, technical reports of WHO, World Bank, Asian Development Bank, and other grey literature will be searched and analyzed. Titles and abstracts will be screened by two independent reviewers, and papers selected for retrieval will be evaluated for methodological validity using standard checklists. Data will be extracted and synthesized using JBI data extraction forms and synthesis tools for risk/etiology. A meta-analysis of quantitative data will, where possible will be performed using R Studio, and where meta-analysis is not possible, the results will be provided in narrative format including tables and figures to aid in data presentation.
Heterogeneous integration of spin-photon interfaces with a
scalable CMOS platform
Authors: Englund Dirk , Li Linsen , De Santis Lorenzo , Harris Isaac , Chen Kevin , Christen Ian , Trusheim Matthew , Song Yixuan , Gao Yihuai , Errando-Herranz Carlos , Du Jiahui , Clark Genevieve , Ibrahim Mohamed , Gilbert Gerald , Han Ruonan 
Published: August 2023

Abstract

Color centers in diamonds have emerged as a leading solid-state platform for advancing quantum technologies, satisfying the DiVincenzo criteria and recently achieving a quantum advantage in secret key distribution. Recent theoretical works estimate that general-purpose quantum computing using local quantum communication networks will require millions of physical qubits to encode thousands of logical qubits, which presents a substantial challenge to the hardware architecture at this scale. To address the unanswered scaling problem, in this work, we first introduce a scalable hardware modular architecture ''Quantum System-on-Chip'' (QSoC) that features compact two-dimensional arrays ''quantum microchiplets'' (QMCs) containing tin-vacancy (SnV^-) spin qubits integrated on a cryogenic application-specific integrated circuit (ASIC). We demonstrate crucial architectural subcomponents, including (1) QSoC fabrication via a lock-and-release method for large-scale heterogeneous integration; (2) a high-throughput calibration of the QSoC for spin qubit spectral inhomogenous registration; (3) spin qubit spectral tuning functionality for inhomogenous compensation; (4) efficient spin-state preparation and measurement for improved spin and optical properties. QSoC architecture supports full connectivity for quantum memory arrays in a set of different resonant frequencies and offers the possibility for further scaling the number of solid-state physical qubits via larger and denser QMC arrays and optical frequency multiplexing networking.
Comparative Analysis of Green Innovation Processes Across Industries: A Cross-Industry Study
Authors: Barbera Salvatore La 
Published: August 2023

Abstract

Amidst global environmental challenges, integrating green innovation across industries is crucial. This paper conducts a cross-industry exploration of green innovation processes. Industries differ in technological expertise, regulatory environments, and resources. We investigate the role of external partners, collaboration strategies, change management, and challenges. Multiple case studies are analyzed, revealing common challenges and unique opportunities. The study underscores the significance of cross-industry insights for fostering green innovation. This paper offers practical insights, guiding industries towards sustainable evolution.
ACE2 Receptor: A Potential Pharmacological Target in COVID-19
Authors: Zhu Yaping , Zhang Shungeng , Wang Zeguang , Wang Zhi , Zhu Shiheng 
Published: August 2023

Abstract:
Studies have shown that injection of recombinant angiotensin-converting enzyme 2
(ACE2) significantly increased circulatory levels of ACE2 activity, reduced cardiac hypertrophy
and fibrosis, and effectively lowered blood pressure. In addition, recombinant ACE2 ameliorated albuminuria
and might contribute to renal protection. Meanwhile, potential pharmacological treatments
based on ACE2 are attracting increasing attention from scientists following a growing understanding
of the role of the ACE2 receptor in the pathogenesis of coronavirus disease 2019
(COVID-19). In this article, we comprehensively summarized the literature on the structure, distribution,
and function of ACE2. More importantly, we draw a conclusion that ACE2 decoys such as
sACE2, hrsACE2 and ACE2-derived peptides, drugs down-regulating the ACE2 or TMPRSS2
gene expression, and the application of epigenetic modifiers and Traditional Chinese Medicine
might represent promising approaches for the future of COVID-19 treatment.
Mechanism of Action of Collagen and Epidermal Growth Factor: A
Review on Theory and Research Methods
Authors: Shahrajabian Mohamad Hesam , Sun Wenli 
Published: August 2023

Abstract:
The most abundant protein found in mammals is collagen, and there are around 28 different
types of collagen found in the human body, but there are five types, namely, Type I, Type II, Type III,
Type V, and Type X, most generally applied in supplements, and the five common types of collagen
are available in various forms and form different sources, which result in various potential benefits.
The epidermal growth factor is one of the main growth factor proteins in the skin, which has an important
function in the production of collagen, hyaluronic acid, and elastin to keep the skin healthy
and dense appearance. It is a single-chain polypeptide of 53 amino acids, which is a potent mitogen
for a variety of cells in vivo and in vitro. It triggers cells to grow, produce, and divide proteins, such as
collagen. It may increase collagen production in granulation tissue by stimulation of fibroblast proliferation.
This review article aims to provide an overview of different collagens and epidermal growth
factors from recently published studies and some important directions for future research. The key
words search for Collagen, Epidermal growth, Polypeptides, Amino acids, Protein, and tissue engineering
were performed using Google scholar, PubMed, and Scopus. Fibrillar collagens are collagen
types I, II, III, V, XI, XXIV, XXVII, and non-fibrillar collagens are collagen types IV, VI, VII, VIII,
IX, X, XII, XIII, XIV, XV, XVI, XVII, XVIII, XIX, XX, XXI, XXII, XXIII, XXV, XXVI, XXVIII,
and XXIX. Collagen I can be found in bone, skin, tendon, cornea and vascular ligature; collagen II
can be discovered in cartilage, vitreous body and gristle; collagen III is the main ingredient of reticular
fibers which is often found alongside type I, the location of collagen III is also in skin, uterus, intestine,
and vessels. Collagen IV can be identified in capillaries, the epithelium-secreted layer of the
basement membrane and forms basal lamina. It forms basal lamina, capillaries, and the epitheliumsecreted
layer of the basement membrane, while Collagen V can be discovered in bones, skin, cornea,
hair, placenta, and cell surfaces. In addition, collagen VI is found in bones, skin, gristle, cornea and
vessels, while collagen VII can be found in skin, bladder, mucous membranes, amniotic fluid and umbilical
cord. Lastly, collagen VIII is found in the skin, heart, kidney, brain, bones, gristle and vessels.
Moreover, collagen X, XI and IX can be found in the gristle.
Exosomes derived from Mouse Bone Marrow Mesenchymal Stem
Cells Attenuate Nucleus Pulposus Cell Apoptosis via the miR-155-
5p/Trim32 Axis
Authors: Chen Fei , Li Shangze , Wu Ji , Guo Qunfeng , Wang Haibin , Ni Bin , Yang Jun 
Published: August 2023

Background:
Lower back pain, shown to be strongly associated with IVDD,
affects approximately 60%–80% of adults and has a considerable societal and economic
impact. Evidence suggests that IVDD, caused by abnormal apoptosis of nucleus
pulposus cells (NPCs), can be treated using MSC-derived exosomes.

Objective:
This study aimed to evaluate the role of miR155-5p/Trim32 in intervertebral
disc disease (IVDD) and elucidate the underlying molecular mechanisms. Deregulating
miR-155 has been shown to promote Fas-mediated apoptosis in human IVDD. Evidence
also suggests that tripartite motif (TRIM)-containing protein 32 (Trim32) is regulated by
miR-155. However, the role of miR155-5p/Trim32 in IVDD remains unclear.

Methods:
Cell viability was checked using CCK-8 kits, and flow cytometry was used to
analyze cell cycle and apoptosis. Cell migration was measured with a Transwell assay,
while a luciferase assay was adopted to study how miR-155-5p interacts with Trim32.
The roles of Trim32 and miR-155-5p were studied by silencing or up-regulating them in
NPCs, while qPCR and immunoblots were used to evaluate mRNA and protein changes,
respectively.

Results:
TNF-α treatment significantly inhibited cell viability but promoted Trim32
expression in primary mouse NPCs. Administration of bone marrow mesenchymal stem
cells (BMSCs) attenuated primary NPC cell cycle arrest and apoptosis induced by TNF-
α. BMSCs-derived exosomes could be taken up by NPCs to inhibit TNF-α-induced cell
cycle arrest and apoptosis through miR-155-5p. Examination of the underlying
mechanism showed that miR-155-5p targeted Trim32. Moreover, Trim32 overexpression
inhibited the effect of BMSCs-derived exosomes on primary mouse NPC cell apoptosis
induced by TNF-α.

Conclusion:
Overall, these findings suggest that exosomes from BMSCs can suppress
TNF-α-induced cell cycle arrest and apoptosis in primary mouse NPCs through the
delivery of miR-155-5p by targeting Trim32. This study provides a promising therapeutic
strategy for IVDD.
Flavonoids as Pyruvate Kinase M2 Inhibitor: An In silico Analysis
Authors: Mishra Raghav , Kaushal Sparsh , Mishra Isha 
Published: August 2023

Background:
The prevalence of cancer in developing nations is a significant issue of concern.
As a result of diverse global influences, this condition has surpassed coronary ailments to become the
foremost cause of mortality. The role of PKM2 (Muscle Pyruvate Kinase 2) has garnered significant interest in the quest for agents in cancer progression. Flavonoids exhibit promise as a framework for the
advancement of chemotherapeutic agents targeting cancer.

Objective:
The principal aim of the present in silico investigation was to ascertain flavonoids as potential
anticancer agents capable of inhibiting the PKM2 enzyme.

Methods:
The preferred ligand molecules were docked to the human PKM2 enzyme using a computational molecular docking simulation technique to determine their affinity for the same enzyme. The molecular
docking simulation was carried out using the AutoDock Vina software.

Results:
The chosen flavonoid docked well with the PKM2 enzyme, suggesting it may stimulate autophagy, hence acting as an anticancer agent.

Conclusion:
In in silico studies, the chosen flavonoids showed a strong binding affinity, indicating that
all of them impede the human PKM2 enzyme and have the potential to be used as cancer treatment alternatives.
The Metabolism Study of Oleraisoquinoline in Rats Using Ultrahigh-
performance Liquid Chromatography-electrospray Coupled with
Quadrupole Time-of-flight Mass Spectrometry and its Bioactivities
Authors: Liu Peishan , Sun Rui , Tian Jiayin , He Fan , Ying Xixiang 
Published: August 2023

Objective:
This study aimed to investigate the main metabolites and metabolic pathways
of oleraisoquinoline in rats, a new alkaloid isolated from Portulaca oleracea L., and test its
antioxidation and anticholinesterase effects.

Methods:
Ultra-high-performance liquid chromatography-electrospray coupled with quadrupole
time-of-flight mass spectrometry (UHPLC-ESI-Q-TOF/MS) was applied to study the metabolism
of oleraisoquinoline. Furthermore, 1,1‑diphenyl‑2‑picrylhydrazyl assay and modified Ellman’s
method were used to test the antioxidation and anticholinesterase effects of oleraisoquinoline, respectively.

Results:
The metabolism results of oleraisoquinoline showed, after its administration through the
tail vein of rats, 4 metabolites in the plasma samples, 17 metabolites in the urine sample, and 2
metabolites in the feces sample. The main metabolic pathways were hydrolyzation, oxidation,
hydroxylation, sulfonation, glucuronidation, acetylation, and methylation. Additionally, IC50
values of antioxidant and anticholinesterase activities were 13.819 ± 0.005 μM and 10.551 ±
0.069 μM, respectively.

Conclusion:
21 metabolites were found in the rat’s plasma, urine, and feces samples, and the metabolic
pathways included hydrolyzation, oxidation, hydroxylation, sulfonation, glucuronidation,
acetylation, and methylation; among them, sulfonation was the main metabolic reaction. Meanwhile,
oleraisoquinoline also showed extremely good antioxidant and anticholinesterase activities.
Incidence and Severity of Adverse Drug Reactions in Medical Intensive
Care Unit
Authors: Shaikh Sana , Raut Asawari , Jambhale Prajkta , Iyer Shivkumar , Shah Jignesh 
Published: August 2023

Background:
Adverse drug reactions (ADRs) curtail patients’ quality of life by virtue of
increasing therapeutic complexity and rising multimorbidity. In India, the frequency of ADRs for
individual drugs and their economic burdens are rarely evaluated. This study aimed at identifying
the incidence and severity of ADRs leading to hospitalization (ADRA) and occurring during a hospital
stay (ADRH).

Objective:
The objective of this study is to evaluate the incidence the incidence and severity of
ADRs in the ICU and their impact on the duration of hospitalization, along with the cost incurred
to treat ADRs in the ICU.

Methods:
Demographic, clinical, and pharmacological data on patients admitted to the ICU were
collected, analyzed and evaluated for ADRs. According to the setting analyzed, a descriptive analysis
of the reactions, suspected medicines, and associated factors was undertaken.

Results:
A total of 208 patients were admitted to the ICU during the study period, of which ADRA
contributed 9.1% of the incidence rate and 8.1% of ADRH in 36 patients. Males had a higher incidence
of ADRs than females. Patients who had ADRs had a substantially longer length of stay than
those who did not. Electrolyte disturbance was the most commonly found ADR. According to the
Hartwig scale and WHO-causality scale, 88.9% were moderate, and 97.2% were possible ADRs,
respectively.

Conclusion:
In this study, a similar incidence rate of ADRA and ADRH was observed. The average
cost for treating ADRA was higher than that for treating ADRH. As a result, identifying and
preventing these reactions is critical, as they cause the patient greater suffering.
A Metric to Characterize Differentially Methylated Region Sets Detected
from Methylation Array Data
Authors: Peng Xiaoqing , Cui Wanxin , Zhang Wenjin , Li Zihao , Zhu Xiaoshu , Yuan Ling , Li Ji 
Published: August 2023

Background:
Identifying differentially methylated region (DMR) is a basic but important task
in epigenomics, which can help investigate the mechanisms of diseases and provide methylation biomarkers
for screening diseases. A set of methods have been proposed to identify DMRs from methylation
array data. However, it lacks effective metrics to characterize different DMR sets and enable a
straight way for comparison.

Methods:
In this study, we introduce a metric, DMRn, to characterize DMR sets detected by different
methods from methylation array data. To calculate DMRn, firstly, the methylation differences of DMRs
are recalculated by incorporating the correlations between probes and their represented CpGs. Then,
DMRn is calculated based on the number of probes and the dense of CpGs in DMRs with methylation
differences falling in each interval.

Result & Discussion:
By comparing the DMRn of DMR sets predicted by seven methods on four scenario,
the results demonstrate that DMRn can make an efficient guidance for selecting DMR sets, and provide
new insights in cancer genomics studies by comparing the DMR sets from the related pathological
states. For example, there are many regions with subtle methylation alteration in subtypes of prostate
cancer are altered oppositely in the benign state, which may indicate a possible revision mechanism in
benign prostate cancer.

Conclusion:
Futhermore, when applied to datasets that underwent different runs of batch effect removal,
the DMRn can help to visualize the bias introduced by multi-runs of batch effect removal. The tool for
calculating DMRn is available in the GitHub repository(https://github.com/xqpeng/DMRArrayMetric).
NMDA Receptors in the Rat Paraventricular Thalamic Nucleus
Reduce the Naloxone-induced Morphine Withdrawal
Authors: Babaei Fatemeh , Kourosh-Arami Masoumeh , Farhadi Mona 
Published: August 2023

Background:
NMDA receptors have a significant role in the development of opioid physical
dependence. Evidence demonstrated that a drug of abuse enhances neuronal excitability in the Paraventricular
Nucleus (PVT). The current research studied whether blocking NMDA receptors through
the administration of MK801 in the PVT nucleus could affect the development of Morphine (Mor) dependence
and hence the behavioral indices induced by morphine withdrawal in rats.

Methods:
Male Wistar rats weighing 250-300 g were used. For induction of drug dependence, we injected
Mor subcutaneously (s.c.) (6, 16, 26, 36, 46, 56, and 66 mg/kg, 2 ml/kg) at an interval of 24
hours for 7 days. Animals were divided into two groups in which the NMDA receptor antagonist,
MK801 (20 mM in 0.1 ml), or its vehicle were applied into the PVT nucleus for 7 days before each
Mor administration. On day 8, after injection of naloxone (Nal, 2.5 mg/kg, i.p.), withdrawal behaviors
were checked for 25 min.

Results:
The current results demonstrated that the blockade of the NMDA receptor in the PVT nucleus
significantly increased withdrawal behaviors provoked by the application of Nal in morphinedependent
(Mor-d) rats.

Conclusion:
We concluded that the NMDA receptor in the PVT nucleus changes the development of
Mor dependence.
The Number of Antiseizure Medications Taken and not the Lipid Profile
was Associated with Seizure Control in Adult Patients with Epilepsy
Authors: Leandro-Merhi Vania Aparecida , de Almeida Souza Tedrus Glória Maria , de Moraes Giovanna Gigolotti Jacober , Ravelli Michele Novaes 
Published: August 2023

Abstract:
Previous studies show changes in lipid metabolism in epilepsy. The aim of this study was to
investigate the association between lipid profile and clinical variables in adult patients with epilepsy
(APE). Seventy-two APE participated in this pilot study at an outpatient neurology service. The lipid
profile (total cholesterol, low-density lipoprotein (LDL) cholesterol, very-low-density lipoproteins
(VLDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides), age at disease onset,
disease duration, seizures frequency, and the number of antiseizure medications (ASM) used were
investigated. Data were analyzed using the Chi-square, Fisher, Mann-Whitney, Spearman coefficient,
and logistic regression tests. There were significant differences in HDL (p = 0.0023) and total cholesterol
(p = 0.0452) levels in connection with the number of ASM used. There was a significant difference
in seizure control among the different numbers of ASM used (p = 0.0382). Higher HDL values
were found in females (p = 0.0170). The logistic regression showed that only the number of ASM used
was associated with seizure control (p = 0.0408; OR = 2.800; 95% CI = 1.044; 7.509). The number of
ASM taken and not the lipid profile was associated with seizure control in APE.
Croton cajucara: Patents and Nanotechnological Advances
Authors: Lima Laís Rocha , da Silva Júnior Francisco Lopes , Arcanjo Daniel Dias Rufino , Medeiros Maciel Maria Aparecida 
Published: August 2023

Abstract:
Croton cajucara Benth showed several pharmacological properties such as: antiinflammatory,
antinociceptive hypoglycemic, lipid-lowering, antiulcer, antiestrogenic, antitumor, antigenotoxic,
antimutagenic, and cardiovascular. The 19-nor-clerodane diterpene transdehydrocrotonin
(t-DCTN or DCTN) is the major bioactive constituent extracted from the bark of this
Croton. Patents for Croton cajucara Benth in the period 2015 to 2022 comprises 14 published documents.
Among them 4 patents are colloidal systems (SM/SNEDDS) loading t-DCTN for pharmacological
applications. Patent registrations highlighted the huge promising biotechnological potential of
Croton cajucara Benth especially in the phytotherapy field, and the correlation with its bioactive constituents
of which t-DCTN showed the foremost results, so this herbal could become an alternative in
the treatment of COVID-19. However, investigation of more recently published patents for clerodane
diterpenes with similar chemical structure of t-DCTN, who previously showed antiviral property must
be carried out and should be searched on several patent data bases.
Design and Synthesis of Circular Antenna Array for Low Side Lobe Level and High Directivity using Artificial Hummingbird Optimization Algorithm
Authors: Kumar Sunil , Singh Harbinder 
Published: August 2023

Background:
Circular antenna arrays are widely used in 5G, IoT, and beamforming applications
of next-generation communications, however attaining the subsidiary lobes along with
directivity is still a challenge. The array parameters could be estimated in real-time using a variety
of standard approaches, but these methods would tends to lag in maintaining appropriate directivity
and even a low side lobe level.

Methods:
To suppress the subsidiary lobe, achieve the required primary lobe direction, and enhance
directivity, an optimization problem is applied in this study. Also with the circular antenna array
problem, an artificial hummingbird algorithm (AHA) is used to accurately determine the regulating
parameters.

Results:
Simulations are performed, and the outcomes are analyzed with those achieved using other
accepted techniques. The results indicated that the artificial hummingbird technique significantly
reduces side lobes while preserving acceptable directivity

Conclusion:
In this work based on the dimensional analysis, it is also possible to achieve high directivity
values alongside low side lobe levels using reduced antenna elements.