bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging roles of p300/CBP in autophagy and autophagy-related human disorders
Authors: Xu Yinfeng , Wan Wei 
Published: June 2023

ABSTRACT
As one of the major acetyltransferases in mammalian cells, p300 (also known as EP300) and its highly related protein CBP (also known as CREBBP), collectively termed p300/CBP, is characterized as a key regulator in gene transcription by modulating the acetylation of histones. In recent decades, proteomic analyses have revealed that p300 is also involved in the regulation of various cellular processes by acetylating many non-histone proteins. Among the identified substrates, some are key players involved in different autophagy steps, which together establish p300 as a master regulator of autophagy. Accumulating evidence has shown that p300 activity is controlled by many distinct cellular pathways to regulate autophagy in response to cellular or environmental stimuli. In addition, several small molecules have been shown to regulate autophagy by targeting p300, suggesting that manipulation of p300 activity is sufficient for controlling autophagy. Importantly, dysfunction of p300-regulated autophagy has been implicated in a number of human disorders, such as cancer, aging and neurodegeneration, highlighting p300 as a promising target for the drug development of autophagy-related human disorders. Here, we focus on the roles of p300-mediated protein acetylation in the regulation of autophagy and discuss implications for autophagy-related human disorders.
Biomimetic Transition Metal Cluster Complexes: Synthetic Studies and Applications in the Reduction of Inert Small Molecules
Authors: Ohki Yasuhiro 
Published: June 2023

Abstract
Transition metal cluster complexes, particularly those containing iron and sulfur, are used as catalysts for the biological reduction of inert small molecules such as N2 and CO2. The structures of these biological clusters are complicated and the protein backbones around the clusters often play important roles in catalysis, hence reproducing or mimicking the enzymatic functions with synthetic cluster complexes remains a challenge. Appropriate assumptions and hypotheses on the relationships between the structures and functions of biological clusters are needed to develop synthetic molecular catalysts inspired by enzymes. This account reviews recent studies by the author and his coworkers on iron-containing biomimetic cluster complexes. Cubic Mo-Fe-S clusters supported by bulky cyclopentadienyl ligands on molybdenum were designed and synthesized, and their Fe sites captured and catalytically converted N2 under reducing conditions. Iron-hydride clusters, which are relevant to the active species of biological and industrial nitrogen fixation, also served as catalysts for the reduction of N2. Furthermore, various metal-sulfur clusters, ranging from a structural mimic of the complex active site of the N2-reducing enzyme to a simple and cubic [Fe4S4] cluster, were found to catalyze the biologically inaccessible direct conversion of CO2 to short-chain hydrocarbons. These studies have demonstrated the potential utility of biomimetic approaches to the catalytic reduction of inert small molecules, through the rational design and synthesis of simple yet appropriate iron-containing cluster complexes.
Mapping inspiration in human resources: A systematic review of themes and approaches
Authors: . Vagisha , P S James , Iyer Vishwanathan 
Published: June 2023

Background: This study was motivated by the need to invigorate research on inspiration, especially within the domain of management. The authors’ objective was to devise a unifying structure for theory building and provide an overview of emergent constructs on inspiration research. Thus, the incremental contribution of the study is that the authors reviewed extant relevant literature and enhanced the focus on research on inspiration in management. Methods: We performed a literature search on empirical studies on inspiration from 15 June to 31 August 2022. We retrieved English articles published between 2003 and 2022. The information sources were Ebscohost, ProQuest, Science Direct, and Scopus. Risk of bias was assessed regarding review methods and the relevance of review to the research questions. We developed a data extraction sheet for the data collection process, considering the systematic review goals to ensure that all the pertinent data was retrieved. Results: Six out of 224 articles were identified for the final review. The excluded articles did not meet the either one or all of the inclusion criteria. The results revealed that there is a vast knowledge gap awaiting empirical research which can have a far-reaching impact on society and management; for instance, the impact of inspiration on performance and the role of moderators such as spirituality, visioning capability, gender variation, and linguistic proficiency. Conclusion: This study recommends that research on inspiration focuses to crystallize inspiration as a construct, identify various dimensions of inspiration, and then firm up a general theory of inspiration with robust empirical evidence. There is a need to expand the scope of the IS by developing and trying out newer competing scales.
Effectiveness of multi-component modular intervention among adults with prehypertension in a village of Dakshina Kannada district - a community-based interventional study – protocol
Authors: Feren Neneh , Thapar Rekha , Unnikrishnan B , Mithra Prasanna , Kumar Nithin , Holla Ramesh , BB Darshan , Kotian Himani 
Published: June 2023

Introduction: The Joint National Committee (JNC 7) report on Prevention, Detection, Evaluation, and Treatment of Hypertension, defined "prehypertension," as individuals with a Systolic Blood Pressure (SBP) in the range of 120–139 mmHg and a (diastolic blood pressure) DBP of 80–89 mmHg. Prehypertension is directly linked with hypertension which is a precursor of CVDs. Owing to its high conversion rate to hypertension, it is important to identify individuals with blood pressures in this category and bring about lifestyle modifications in them that can prevent them from being hypertensive and from developing cardiovascular diseases later in life. Methods: This randomized controlled trial will be done among the selected pre-hypertensive adults of all genders residing in Kateel Gram panchayat, Dakshina Kannada district, Karnataka. A baseline survey will be done initially to assess the level of prehypertension among the study population. To study the effectiveness of the intervention, 142 individuals will be randomly allocated using block randomization technique to intervention and control groups. A multi-component module (educational intervention) will be developed, validated, and administered to participants in the intervention group, while the control group receives standard care. Each participant will then be followed up once in four months till the end of the study period of one year to assess for changes in SBP, DBP, WHR, BMI, stress levels, and usage of tobacco and alcohol. Ethics and dissemination: Institutional Ethics Committee approval was obtained from Kasturba Medical College in Mangalore, India. The plans for dissemination of findings include presenting at scientific conferences and publishing in scholarly journals.
Employee-centric discussions and economic context: Evidence from Chairman speeches
Authors: . Vagisha , P S James , Iyer Vishwanathan 
Published: June 2023

Background: This paper offers a thematic interpretation of patterns of employee-centric discussions (ECD) in chairman speeches during the period of 2004-2008 and 2010-2014 wherein the former is considered the pre-recession period and the latter the post-recession period. A situation like recession calls for focus on employee relations and development. In the economic context of recession, the paper suggests that the attitudinal approach of top echelons towards employees can in part be explained by the themes of ECDs through the comparative analysis of pre- and post-recession periods. Methods: This paper adopts a qualitative content analysis approach to study the themes of ECDs present in the chairman’s speech, in the view of two economic contexts i.e., pre- and post-recession. Companies were identified from the CNX 2016 Nifty 50-stock index, then chairman’s statements were downloaded using each company’s official website which met the inclusion criteria. Data collection was from November 2020-March 2021. Thematic analysis was conducted using Atlas.ti, all ECD excerpts were extracted from the speeches based on the referring terms used for employees. Keywords were identified using Atlas.ti software. Preliminary coding of the ECD excerpts was carried out at the sentence level adopting the summative approach. Tagged codes were then used as keywords to extract excerpts concerning employees which did not have referring terms in it. Results: The finding suggests that the ECDS have four dominant themes - acknowledgment and appreciation, confidence, employee relations, and employee value. It also indicates an increase in ECDs in the post-recession period.
Heart rate variability as a prognostic marker in critically ill patients
Authors: Kakde Yogesh , Bawankule Shilpa , Mahajan Satish , Acharya Sourya , Kumar Sunil , Gaidhane Abhay 
Published: June 2023

Background: Heart rate variability (HRV) can be used to assess cardiac autonomic activity in critically ill patients. Heart rate variability is termed as fluctuation in the time interval between adjacent heartbeats. The equilibrium among the sympathetic and parasympathetic subgroups of the autonomic nervous system (ANS) is essential for the maintenance of systemic homeostasis and effective response to external stressors. Hence we aimed this study to determine whether heart rate variability can be used as a prognostic marker in critically ill patients. Methods: A cross-sectional study was conducted among 225 consecutive critically ill patients admitted to the medicine Intensive care unit (ICU) of AVBRH, Sawangi (Meghe) based on the inclusion and exclusion criteria. The selected participants were evaluated for 24 hours Heart Rate Variability (HRV) and APACHE 4 score. Outcomes like mortality and survival were corelated with 24 hours Heart Rate Variability and APACHE 4 score. Results: The variables were significantly associated (p<0.05) with Standard deviation of the average Normal-to normal HRV intervals (SDANN) and Standard deviation of the NN intervals (SDNN). The variables were also significantly associated (p<0.05) with the variable High frequency (HF), High frequency/Low frequency (LF/HF) ratio. LF/HF parameter was abnormal in 86% of patients who died as compared to 54% of the patients who survived (p-value <0.001). Conclusions: Out of the 225 participants, 20% died during the study period. APACHE 4, Glasgow coma scale (GCS) score, and LF were significantly and independently associated with mortality. Decrease in Low frequency parameter of 24 hours Heart Rate Variability identified mortality with accuracy of 74% with 81.2% specificity, and 46.7 % sensitivity
Willingness-to-pay for a hypothetical Ebola vaccine in Indonesia: A cross-sectional study in Aceh
Authors: Mudatsir Mudatsir , Anwar Samsul , Fajar Jonny Karunia , Yufika Amanda , Ferdian Muhammad N. , Salwiyadi Salwiyadi , Imanda Aga S. , Azhars Roully , Ilham Darul , Timur Arya U. , Sahputri Juwita , Yordani Ricky , Pramana Setia , Rajamoorthy Yogambigai , Wagner Abram L. , Jamil Kurnia F. , Harapan Harapan 
Published: June 2023

Background: Some Ebola vaccines have been developed and tested in phase III clinical trials. However, assessment of whether public have willingness to purchase or not, especially in unaffected areas, is lacking. The aim of this study was to determine willingness to pay (WTP) for a hypothetical Ebola vaccine in Indonesia. Methods: A cross-sectional study was conducted from 1 August to 30 December 2015 in five cities in Aceh province of Indonesia. Patients’ family members who visited outpatient departments were approached and interviewed about their sociodemographic characteristics, knowledge of Ebola, attitude towards vaccination practice and their WTP for a hypothetical Ebola vaccine. A multivariable linear regression model assessed the relationship between these explanatory variables and WTP. Results: During the study, 500 participants were approached and interviewed. There were 424 (84.8%) respondents who completed the interview and 74% (311/424) expressed their acceptance for an Ebola vaccine. There were 288 participants who were willing to pay for an Ebola vaccine (92.6% out of 311). The mean of WTP was US$2.08 (95% CI: 1.75-2.42). The final multivariable model indicated that young age, high educational attainment, working as a private employee, entrepreneur or civil servant (compared to farmers), being unmarried, and residing in a suburb (compared to a city) were associated with higher WTP. Conclusions: Although the proportion of the participants who would accept the Ebola vaccine was relatively high, the amount they were willing to pay for Ebola vaccine was very low. This finding would indicate the need of subsidies for Ebola vaccine in the country.
Acute effects of cigarette smoke on Endothelial Nitric Oxide synthase, vascular cell adhesion molecule 1 and aortic intima media thickness
Authors: Ardiana Meity , Santoso Anwar , Hermawan Hanestya Oky , Nugraha Ricardo Adrian , Pikir Budi Susetyo , Suryawan I. Gde Rurus 
Published: June 2023

Background. Cigarette smoking could induce endothelial dysfunction and the increase of circulating markers of inflammation by activation of monocytes. This can lead to increased intima media thickness (IMT) of entire blood vessels and result in acceleration of the atherosclerosis process. However, to our knowledge, little is known about the role of cigarette smoking in this atherosclerotic inflammatory process. The aim of this study is to explore the link between cigarette smoking and its effect on endothelial nitric oxide synthase (e-NOS) and vascular cell adhesion molecule 1 (VCAM-1). Methods. An experimental study with a post-test only controlled group design was used. We used 18 Wistar rats (Rattus norvegicus) randomly subdivided into two groups: group K (-) were not exposed to tobacco smoke, whereas group K (+) were exposed to smoke equivalent of more than 40 cigarettes for 28 days daily. After 28 days, samples were analyzed for e-NOS, VCAM-1 and aortic IMT. Results. Our results indicate that tobacco smoke can enhance the expression of VCAM-1 on rat cardiac vascular endothelial cells, resulting in a decreased expression of e-NOS level and increase of aortic IMT. Linear regression model found that eNOS level negatively correlated wiith aortic IMT (r2 = 0.584, β = -0.764, p < 0.001), whereas VCAM-1 expression did not correlate with aortic IMT (r2 = 0.197, p = 0.065). Conclusion. Low e-NOS level and high VCAM-1 level observed after cigarette smoke exposure which may increase aortic IMT.
Investor demand in syndicated EFSF/ESM bond issuances
Authors: Hillebrand Martin , Mravlak Marko , Schwendner Peter 
Published: June 2023

European Financial Stability Facility (EFSF) and European Stability Mechanism (ESM) were set up at the peak of the European sovereign debt crisis to issue bonds and lend to countries under current funding stress. This study analyses investor demand in syndicated bond issuances of EFSF and ESM from 2014 to 2020 on an unprecedented granularity level using a dataset of individual orders with statistical inference. Particularly, we investigate orderbook dynamics for three main aspects: first, we determine the main factors segmenting investor demand. Second, we analyse price dynamics in the transactions and their relation to investor demand. Third, we investigate whether any indications of orderbook inflation might explain the increased volatility in orderbook volume. We identify issuance tranche and tenor as the main determinants of investor demand that are largely anticipated in the notional. Further, we note that ESM is doing economical pricing, where the new issue premium tends to be lower in a market context with larger demand. Lastly, we find a mixture of an increasing number and an increasing volume of orders as drivers of large order books. This confirms that there are no indications of orderbook inflation tendencies in the analysed time period.
Consenting surgical patients for the risk of contracting COVID-19 during the hospital stay
Authors: Al Aaraj Mahmoud , Alkilani Yara , Abdeen Bashar , Yang Yu-Hsuen , Alqaisi Mohammed , Kaul Sandeep , Wain Mehmood 
Published: June 2023

Background/Aims Postoperative pulmonary complications occur in half of patients with perioperative COVID-19 and are associated with high mortality. The Royal College of Surgeons of England published guidance on recovery of surgical services during and after the COVID-19 pandemic. One part of this toolkit looked at unique considerations during the COVID-19 pandemic, in particular the risk of contracting COVID-19 while in the hospital. This quality improvement project sought to assess consent forms from the authors' surgical department to see if patients were being consented for the risks associated with COVID-19 during their stay in the hospital. Methods Over an 8-week period in October and November 2020, consent forms for patients under the general surgery department were audited four times against the Royal College of Surgeons of England's standards. Patients were included in the study if they were deemed to have capacity to consent to a procedure. Posters in the hospital, generic emails and teaching sessions were used as the interventions after each cycle of the audit. Results Baseline measurement showed that fewer than 37% of patients were consented for the risk of contracting COVID-19; this rose to almost 61%, 71% and 85% in the second, third and fourth parts of the project respectively. Year 1 and 2 core surgical trainees and clinical fellows below registrar level showed the greatest improvement, from consenting only 8% of patients up to 100% of patients, while specialty registrars showed improvement in consenting from 52% to 73%. The change was sustained 2 years after the initial interventions, with almost 60% of patients consented for the risk associated with in-hospital COVID-19 infection in March 2023. Conclusions Errors or omission of important elements in documentation of patient consent can delay operations, expose hospital trusts to medicolegal risk and ultimately may represent a failure to fully respect patient autonomy. This project sought to evaluate consenting practice during the presence of COVID-19 in society. While the teaching session showed some improvement in the consenting for the risk of COVID-19, emails and visual posters increased the consent rates further.
Changes in trends and patterns of glycaemic control at Ghana’s National Diabetes Management and Research Centre during the era of the COVID-19 pandemic
Authors: Swaray Swithin Mustapha , Tetteh John , Djonor Sampson Kafui , Ekem-Ferguson George , Clottey Ruth Yawa , Yacoba Atiase , Yawson Alfred Edwin 
Published: June 2023

Background
Maintaining optimal glycaemic control (GC) delays the onset and progression of diabetes-related complications, especially microvascular complications. We aimed to establish the trend and pattern of GC, and its associated factors in persons living with diabetes (PLWD), and to examine the influence of COVID-19 on GC.

Methods
A retrospective study involving secondary data from 2,593 patients’ physical records from the National Diabetes Management and Research Centre (NDMRC) in Accra, extracted from 2015–2021. Growth rate of GC was assessed, and ordinal logistic and Poisson models weighted with Mahalanobis distance matching within propensity caliper were adopted to assess the impact of COVID-19 pandemic on GC. Stata 16.1 was utilized and the significant value set as p≤0.05.

Results
GC pattern indicated a steady deterioration ranging from 38.6% (95%CI = 34.5–42.9) in 2015 to 69.2% (95%CI = 63.5–74.4) in 2021. The overall growth from 2015–2021 was 8.7%. Being a woman and increasing diastolic pressure significantly increase the likelihood of poor glycaemic control (PGC) by 22% and 25%, respectively compared with their respective counterparts [aOR(95%CI = 1.01–1.46 and 1.25(1.10–1.41), respectively]; whilst lower age increased the risk of PGC throughout the years. We found that risk of PGC during the era of COVID-19 was approximately 1.57(95%CI = 1.08–2.30) times significant, whilst the adjusted prevalence ratio (aPR) of PGC during the era of COVID-19 was approximately 64% significantly higher than the era without COVID-19 (aPR = 1.64, 95%CI = 1.10–2.43).

Conclusion
GC worsened from 2015–2021, especially during the COVID era. Younger age, uncontrolled blood pressure and/or being a woman were associated with PGC. The NDMRC and other centres that provide specialist healthcare in resource-limited settings, must determine the factors that militate against optimal service delivery in the era of the COVID-19 pandemic, and implement measures that would improve resilience in provision of essential care in the face of shocks.
Examining decisional needs and contextual factors influencing fertility status assessment among young female survivors of childhood cancer: A sequential mixed methods study protocol
Authors: Cherven Brooke , Ivankova Nataliya V. , Spencer Jessica B. , Fitzpatrick Anne M. , Burns Karen C. , Demedis Jenna , Hoefgen Holly R. , Mertens Ann C. , Klosky James L. 
Published: June 2023

Introduction
Female cancer survivors who received gonadotoxic cancer treatment are at risk for profound diminished ovarian reserve and/or primary ovarian insufficiency with resulting infertility, which can be associated with distress and decreased quality of life.. Despite prioritizing future parenthood, many survivors are unsure of the impact of their treatment on their future fertility, and little is known about the perceived reproductive health needs and factors associated with receipt of a fertility status assessment (FSA). There is a lack of developmentally appropriate reproductive health decisional support interventions available for emerging adult cancer survivors. This study will explore the perceived reproductive health needs of emerging adult female survivors of childhood cancer and to identify decisional and contextual factors that influence pursuit of FSA using an explanatory sequential quantitative to qualitative mixed methods design.

Methods and analysis
This study will enroll 325 female survivors (aged 18 to 29 years and >1-year post treatment; diagnosed with cancer < age 21 years) from four cancer centers in the United States. Sociodemographic and developmental factors, reproductive knowledge and values, decisional needs, and receipt of an FSA will be assessed through a web-based survey. Informed by survey findings, a subset of participants will be recruited for qualitative interviews to explore decisional factors associated with uptake of an FSA. Clinical data will be abstracted from the medical records. Multivariable logistic regression models will be developed to identify factors associated with FSA and qualitative descriptive analysis will be used to develop themes from the interviews. Quantitative and qualitative findings will be merged using a joint display to develop integrated study conclusions and direct future interventional research.