bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why customers buy an online product? The effects of advertising attractiveness, influencer marketing and online customer reviews
Authors: Arief Mohammad , Mustikowati Rita Indah , Chrismardani Yustina 
Published: September 2023

PurposeDigitalization in marketing activities has made it easier for people to make purchase decision. This platform encourages every firm to optimize digitalization as part of its marketing strategy. Optimization of attractive digital marketing involves advertising attractiveness, influencer marketing and online customer reviews. This study aims to investigate advertising attractiveness, influencer marketing and online customer reviews on purchase decision.Design/methodology/approachThe study was conducted with a quantitative approach. A total of 120 respondents were involved in this study by using convenience sampling techniques in data collection. Multiple linear regression was used to analyze the data.FindingsThe results of the study show that influencer marketing and online customer reviews have an impact on online purchase decision. Meanwhile, advertising attractiveness does not show any influence on purchase decision.Practical implicationsDespite the start-ups have modified the website by increasing the content to make it more informative, it seems that customers are not interested in making a purchase. Therefore, notwithstanding the role of website attractiveness, the use of physical attractiveness is still considered an effective way to encourage customers to make purchasing decisions. In this way, a firm needs to make adjustments between the customers' personality, lifestyle and attitudes and endorsers.Originality/valueThis study developed previous empirical studies which a positive relationship between advertising attractiveness, influencer marketing, online customer reviews and purchase decision. The development of the model was carried out by elaborating variable indicators. In addition, the source of increasing credibility was not based on physical attractiveness, but rather emphasizes the website quality.
Limbic brain subregions associated with mental health symptoms in youth with and without prenatal alcohol exposure
Authors: Nakhid Daphne , Patel Darpal , McMorris Carly A. , Gibbard W. Ben , Tortorelli Christina , Pei Jacqueline , Lebel Catherine 
Published: September 2023

AbstractBackgroundPrenatal alcohol exposure (PAE) can result in reduced brain volume and an increased risk of mental health challenges. Limbic brain structures such as the hippocampus, thalamus, and amygdala often exhibit smaller volumes in youth with PAE, and similar volume reductions are observed in unexposed youth with symptoms of depression, bipolar disorder, anxiety, and schizophrenia. However, the role of volume reductions in these brain regions in mental health challenges remains unclear for individuals with PAE.MethodsThirty‐four youth with PAE and 72 unexposed youth aged 7–16 years completed a T1‐weighted magnetic resonance imaging scan. FreeSurfer was used to process and extract volumes for hippocampal subfields, thalamic subnuclei, and amygdalar subnuclei. Depression and anxiety symptoms were measured using the Behavioral Assessment System for Children (BASC‐2/3‐PRS), the Children's Depression Inventory, and the Multidimensional Anxiety Scale for Children. We tested whether limbic subregion volumes differed between youth with and those without PAE and whether volumes were associated with depression and/or anxiety symptoms, controlling for age and gender.ResultsMultiple hippocampal and thalamic subregions, but not amygdalar subnuclei, were smaller in individuals with PAE. Multiple group‐brain interactions were observed for depression symptoms and subregion volumes. Negative associations between anxiety and limbic subregions were observed across groups.ConclusionsThese findings show extensive volume reductions in the hippocampus and thalamus in youth with PAE. PAE also appears to disrupt the association between depression symptoms and limbic subregions in youth, which may have implications for interventions in these individuals. Anxiety symptoms in youth with and without PAE are similarly associated with limbic volumes.
Letter: future studies of high‐dose thiamine should consider whether its effects on fatigue are related to the inhibition of carbonic anhydrase isoenzymes
Authors: Lubell Jeffrey M. 
Published: September 2023

LINKED CONTENTThis article is linked to Bager et al papers. To view these articles, visithttps://doi.org/10.1111/apt.16166andhttps://doi.org/10.1111/apt.16293
Predicting clinical decompensation in patients with cirrhosis using the Hepquant‐SHUNT test
Authors: Fallahzadeh Mohammad Amin , Hansen Daniel J. , Trotter James F. , Everson Gregory T. , Saracino Giovanna , Rahimi Robert S. , Helmke Steve , Boutte Jodi , Asrani Sumeet K. 
Published: September 2023

SummaryBackgroundEarly identification of risk for decompensation in clinically stable cirrhotic patients helps specialists target early interventions and supports effective referrals from primary care providers to specialty centres.AimsTo examine whether the HepQuant‐SHUNT test (HepQuant LLC, Greenwood Village, Colorado, USA) predicts decompensation and the need for liver transplantation, hospitalisation or liver‐related death.MethodsThirty‐five compensated and 35 subjects with a previous episode of decompensation underwent the SHUNT Test and were followed for a median of 4.2 years. The disease severity index (DSI) (range 0‐50) was examined for association with decompensation in compensated patients; and liver transplantation, liver‐related death, and the number and days of liver related hospitalisations in all. DSI prediction of decompensation was also evaluated in 84 subjects with compensated cirrhosis from the Hepatitis C Antiviral Long‐Term Treatment against Cirrhosis Trial (HALT‐C) followed for a median of 5.8 years.ResultsAt baseline, subjects with prior decompensation had significantly higher DSI than compensated subjects (32.6 vs 20.9, P < 0.001). DSI ≥24 distinguished the decompensated from the compensated patients and independently predicted adverse clinical outcomes (hazard ratio: 4.92, 95% confidence interval: 1.42‐17.06). In the HALT‐C cohort, 65% with baseline DSI ≥24 vs 19% with DSI <24 experienced adverse clinical outcomes (relative risk 3.45, P < 0.0001).ConclusionsThe SHUNT test is a novel, noninvasive test that predicts risk of decompensation in previously compensated patients. DSI ≥24 is independently associated with risk for clinical decompensation, liver transplantation, death and hospitalisation.
Editorial: stratifying risk of adverse outcomes in cirrhosis: the Hepquant SHUNT test
Authors: Maan Raoel , Sonneveld Milan J. 
Published: September 2023

LINKED CONTENTThis article is linked to Fallahzadeh et al and Asrani & Everson papers. To view these articles, visit https://doi.org/10.1111/apt.16283 and https://doi.org/10.1111/apt.16311
Letter: is the radiation therapy causing an IBD flare, or the IBD predisposing to radiation toxicity? Authors' reply
Authors: Laharie David , Riviere Pauline 
Published: September 2023

LINKED CONTENTThis article is linked to Broussard et al and Lim et al papers. To view these articles, visit https://doi.org/10.1111/apt.16176 and https://doi.org/10.1111/apt.16289
Editorial: an expert consensus to standardise the assessment of histological disease activity in Crohn’s disease clinical trials—a missing link. Authors' reply
Authors: Jairath Vipul , Almradi Ahmed , Pai Rish K. , Ma Christopher 
Published: September 2023

LINKED CONTENTThis article is linked to Almradi et al paper. To view this article, visit https://doi.org/10.1111/apt.16248
Editorial: co‐morbid gastrointestinal conditions are an important consideration in IBS management
Authors: Simons Madison , Taft Tiffany H. 
Published: September 2023

LINKED CONTENTThis article is linked to Black et al and Black & Ford papers. To view these articles, visit https://doi.org/10.1111/apt.16322 and https://doi.org/10.1111/apt.16351
The molecular spectrum of amyloid‐beta (Aβ) in neurodegenerative diseases beyond Alzheimer's disease
Authors: Ichimata Shojiro , Yoshida Koji , Li Jun , Rogaeva Ekaterina , Lang Anthony E. , Kovacs Gabor G. 
Published: September 2023

AbstractThis study investigated the molecular spectrum of amyloid‐beta (Aβ) in neurodegenerative diseases beyond Alzheimer's disease (AD). We analyzed Aβ deposition in the temporal cortex and striatum in 116 autopsies, including Lewy body disease (LBD; N = 51), multiple system atrophy (MSA; N = 10), frontotemporal lobar degeneration‐TDP‐43 (FTLD‐TDP; N = 16), and progressive supranuclear palsy (PSP; N = 39). The LBD group exhibited the most Aβ deposition in the temporal cortex and striatum (90/76%, respectively), followed by PSP (69/28%), FTLD‐TDP (50/25%), and the MSA group (50/10%). We conducted immunohistochemical analysis using antibodies targeting eight Aβ epitopes in the LBD and PSP groups. Immunohistochemical findings were evaluated semi‐quantitatively and quantitatively using digital pathology. Females with LBD exhibited significantly more severe Aβ deposition, particularly Aβ42 and Aβ43, along with significantly more severe tau pathology. Furthermore, a quantitative analysis of all Aβ peptides in the LBD group revealed an association with the APOE‐ε4 genotypes. No significant differences were observed between males and females in the PSP group. Finally, we compared striatal Aβ deposition in cases with LBD (N = 15), AD without α‐synuclein pathology (N = 6), and PSP (N = 5). There were no differences in the pan‐Aβ antibody (6F/3D)‐immunolabeled deposition burden among the three groups, but the deposition burden of peptides with high aggregation capacity, especially Aβ43, was significantly higher in the AD and LBD groups than in the PSP group. Furthermore, considerable heterogeneity was observed in the composition of Aβ peptides on a case‐by‐case basis in the AD and LBD groups, whereas it was relatively uniform in the PSP group. Cluster analysis further supported these findings. Our data suggest that the type of concomitant proteinopathies influences the spectrum of Aβ deposition, impacted also by sex and APOE genotypes.
Synthesis of flurbiprofen thiadiazole urea derivatives and assessment of biological activities and molecular docking studies
Authors: Zengin Kurt Belma , Altundağ Özlem , Tokgöz Merve Nur , Öztürk Civelek Dilek , Tuncay Fulya Oz , Cakmak Ummuhan , Kolcuoğlu Yakup , Akdemir Atilla , Sönmez Fatih 
Published: September 2023

AbstractTotally 15 novel flurbiprofen urea derivatives were synthesized bearing the thiadiazole ring. Their inhibition effects on tyrosinase were determined. 3c was found to be the strongest inhibitor with the IC50 value of 68.0 μM against tyrosinase. The enzyme inhibition types of the synthesized compounds were determined by examining the kinetic parameters. The inhibition type of 3c was determined as uncompetitive and the Ki value was calculated as 36.3 μM. Moreover, their cytotoxic effects on hepatocellular carcinoma (HepG2), colorectal carcinoma (HT‐29), and melanoma (B16F10) cell lines were evaluated. According to the cytotoxicity results, 3l (IC50 = 14.11 μM) showed the highest cytotoxicity on the HT‐29 cells, while 3o (IC50 = 4.22 μM) exhibited the strongest cytotoxic effect on HepG2 cell lines. Also, 3j (IC50 = 7.55 μM strongly affected B16F10. The effects of synthesized compounds on the healthy cell line were evaluated on the CCD‐986Sk cell line. Molecular modelling studies have indicated the potential binding interactions of the uncompetitive inhibitor 3c with the enzyme‐substrate complex.
Evaluation of the adjunctive use of Er:YAG laser or erythritol powder air‐polishing in the treatment of peri‐implant mucositis: A randomized clinical trial
Authors: Clementini Marco , Fabrizi Simone , Discepoli Nicola , Minoli Margherita , De Sanctis Massimo 
Published: September 2023

AbstractAimTo assess the efficacy of Er:YAG laser (ERL) and erythritol powder air‐polishing (AP) in addition to the submarginal instrumentation in the non‐surgical treatment of peri‐implant mucositis (PM).Materials and MethodsPatients with at least one implant diagnosed with PM were included in the present 6‐month randomized clinical trial (RCT). Implants were randomly assigned to one of the three treatment groups after submarginal instrumentation: AP (test 1 group), ERL (test 2 group) or no adjunctive methods (control group). The primary and secondary outcomes were, respectively, bleeding on probing (BoP) reduction and, complete disease resolution (total absence of BoP) and probing pocket depth (PPD) changes. The patient and the implant were considered the statistical unit. A multivariate logistic regression analysis was performed.ResultsA total of 75 patients were enrolled in the study. At each time point, significant BoP and PPD reductions were observed within each group. Intergroup analysis did not show statistically significant differences. Complete disease resolution ranged between 29% and 31%. The logistic regression showed that supramucosal restoration margin, PPD < 4 mm and vestibular keratinized mucosa (KM) significantly influenced the probability to obtain treatment success.ConclusionThe adjunctive use of AP and ERL in PM non‐surgical therapy does not seem to provide any significant or clinically relevant benefit in terms of BoP and PPD reductions and complete disease resolution, over the use of submarginal instrumentation alone. Baseline PPD < 4 mm, presence of buccal KM and supramucosal restoration margin may play a role in the complete resolution of PM.
Pharmacokinetics, safety, and tolerability of BMS‐986263, a lipid nanoparticle containing HSP47 siRNA, in participants with hepatic impairment
Authors: Qosa Hisham , de Oliveira Claudia H. M. C. , Cizza Giovanni , Lawitz Eric J. , Colletti Nicholas , Wetherington Jeffrey , Charles Edgar D. , Tirucherai Giridhar S. 
Published: September 2023

AbstractBMS‐986263 is a retinoid‐conjugated lipid nanoparticle delivering small interfering RNA designed to inhibit synthesis of HSP47 protein, a collagen‐specific chaperone protein involved in fibrosis development. This is a phase I, open‐label, two‐part study evaluating pharmacokinetics and safety of BMS‐986263 in participants with hepatic impairment (HI). Part 1 (n = 24) of this study enrolled two cohorts with mild and moderate HI and a separate cohort of age‐ and body mass index (BMI)‐matched participants with normal hepatic function. Part 2 enrolled eight participants with severe HI and eight age‐ and BMI‐matched participants with normal hepatic function. All participants received a single intravenous 90 mg BMS‐986263 infusion. Compared with normal‐matched participants, geometric mean area under the plasma concentration‐time curve time zero to the time of the last quantifiable concentration (AUC(0‐T)) and AUC from zero to infinity (AUC(INF)) of HSP47 siRNA were similar in participants with mild HI and 34% and 163% greater in those with moderate and severe HI, respectively, whereas the maximum plasma concentration was ~25% lower in mild and moderate HI groups but 58% higher in the severe HI group than in the normal group. Adverse events were reported by two of eight, four of eight, and three of eight participants with mild, moderate, or severe HI, respectively; none were reported in the normal‐matched group. Overall, single‐dose BMS‐986263 was generally safe and well‐tolerated and dose adjustment is not considered necessary for participants with mild or moderate HI. Although available data do not indicate that dose adjustment should be performed in patients with severe HI; the optimal posology of BMS‐986263 in patients with severe HI may be determined later in its clinical development when additional data to establish exposure‐safety/efficacy relationship becomes available.
Gamma‐patterned sensory stimulation reverses synaptic plasticity deficits in rat models of early Alzheimer's disease
Authors: Yang Yin , Ondrejcak Tomas , Hu Neng‐Wei , Islam Sadia , O'Rourke Eugene , Reilly Richard B. , Cunningham Colm , Rowan Michael J. , Klyubin Igor 
Published: September 2023

AbstractNon‐invasive sensory stimulation in the range of the brain's gamma rhythm (30–100 Hz) is emerging as a new potential therapeutic strategy for the treatment of Alzheimer's disease (AD). Here, we investigated the effect of repeated combined exposure to 40 Hz synchronized sound and light stimuli on hippocampal long‐term potentiation (LTP) in vivo in three rat models of early AD. We employed a very complete model of AD amyloidosis, amyloid precursor protein (APP)‐overexpressing transgenic McGill‐R‐Thy1‐APP rats at an early pre‐plaque stage, systemic treatment of transgenic APP rats with corticosterone modelling certain environmental AD risk factors and, importantly, intracerebral injection of highly disease‐relevant AD patient‐derived synaptotoxic beta‐amyloid and tau in wild‐type animals. We found that daily treatment with 40 Hz sensory stimulation for 2 weeks fully abrogated the inhibition of LTP in all three models. Moreover, there was a negative correlation between the magnitude of LTP and the level of active caspase‐1 in the hippocampus of transgenic APP animals, which suggests that the beneficial effect of 40 Hz stimulation was dependent on modulation of pro‐inflammatory mechanisms. Our findings support ongoing clinical trials of gamma‐patterned sensory stimulation in early AD.
A 30% reduction in switchgrass rhizome reserves did not decrease biomass yield
Authors: Tejera‐Nieves Mauricio , Walker Berkley J. 
Published: September 2023

AbstractA long‐standing question in perennial grass breeding and physiology is whether yield improvement strategies could compromise winter survival. Since perennial grasses rely on stored carbohydrates for winter maintenance and spring regrowth, yield improvement strategies could reduce winter survival if they increase biomass and grain yields at the expense of carbon allocation to storage. Therefore, it is crucial to comprehend the dependence of regrowth on storage reserves. We experimentally depleted switchgrass (Panicum virgatumL.) rhizome reserves by storing rhizomes for 2 weeks at 5°C (control treatment) and 25°C (reserve‐depleted treatment). During the storage period rhizome respiration was 5.3× higher at 25°C (0.010 μmol CO2 g−1 min−1at 5°C vs. 0.054 μmol CO2 g−1 min−1at 25°C;p < 0.0001) and the starch content was depleted by 30% by the end of storage. Surprisingly, reserve‐depleted switchgrass had 60% larger leaf area (LA; LAcontrol = 149 cm2 pot−1vs. LAdepleted = 239 cm2 pot−1;p = 0.013) and produced ~40% more aboveground biomass than control plants (9.46 g pot−1vs. 6.63 g pot−1;p = 0.112). In addition, reserve‐depleted switchgrass restored its rhizome starch reserves to pre‐storage levels. Switchgrass showed a large plasticity among its source‐sink components to buffer the imposed reserve depletion. It increased plant photosynthesis by increasing the photosynthetic leaf area while keeping photosynthesis constant on a leaf area basis and readjusted the timing and activity of sink organs. These results suggest that switchgrass, and potentially other perennial grasses, largely over‐invest in storage reserves. Therefore, current breeding strategies in perennial grasses aimed to extend the aboveground growing season should not compromise crop persistence. Our study also has implications on long‐term yield dynamics as it highlights sink limitations as potential driver of the yield decline commonly observed in perennial grasses 5+ years after cultivation.
Ferroelastic structure AlNb1/2Ta1/2O4 ceramics with improved thermophysical and mechanical properties
Authors: Zhang Yuxuan , Wang Jun , Song Jianbo , Zhang Luyang , Tian Jiang , Gu Cang , Su Tao , Feng Jing 
Published: September 2023

AbstractEffect of B site doping on structural, thermophysical, and mechanical properties of AlNbxTa1‐xO4 ceramics obtained by solid‐phase sintering were investigated in this work. Ferroelastic domain structures derived from the reversible second‐order ferroelastic transformation between the tetragonal (t) and monoclinic (m) contribute to improving the high‐temperature fracture toughness of AlNbxTa1‐xO4 ceramics, and the room fracture toughness of AlNb1/2Ta1/2O4 ceramics is 3.4 MPa·m0.5. The brittleness index of AlNb1/2Ta1/2O4 (2.6 μm−0.5) is also lower than AlTaO4, which indicates that has better damage tolerance. Compared with single‐component AlTaO4 and AlNbO4, the AlNb1/2Ta1/2O4 has a lower thermal conductivity due to enhanced phonon scattering caused by mass disorder and lattice distortion effects. Additionally, AlNb1/2Ta1/2O4 has a good match with the coefficient of thermal expansion of ceramic matrix composites (CMCs), and hence, AlNb1/2Ta1/2O4 has a considerable potential to be the candidate material for thermal/environmental barrier coatings (T/EBCs).
Changes in the bioaccessibility of citrus polyphenols during industrial freezing process
Authors: Ozdemirli Nurdan , Kamiloglu Senem 
Published: September 2023

SummaryCitrus fruits can be consumed fresh or they can be subjected to various processes including freezing to extend their shelf life. The aim of the current study was to evaluate the bioaccessibility of polyphenols in samples collected at different stages of the industrial freezing process of oranges and grapefruits. The major polyphenols were identified and quantified using UPLC‐ESI‐MS/MS and HPLC‐PDA, respectively. In addition, spectrophotometric methods were employed to determine the total phenolic and flavonoid contents along with total antioxidant capacity. The results showed that the bioaccessibility of flavonoids from frozen citrus fruits (26%–64%) was found to be lower than that of fresh fruits (27%–127%). Similarly, bioaccessibility of phenolic acids from frozen oranges (64%–76%) was significantly lower than that of fresh fruits (126%–152%). On the contrary, phenolic acids of frozen grapefruits were found to be more bioaccessible compared to fresh fruits (64%–217% and 50%–95%, respectively).
Immunometabolism in the pathogenesis of asthma
Authors: Qin Ziwen , Chen Yujuan , Wang Yue , Xu Yeyang , Liu Tingting , Mu Qian , Huang Chuanjun 
Published: September 2023

AbstractBronchial asthma is a heterogeneous disease characterised by chronic airway inflammation. A variety of immune cells such as eosinophils, mast cells, T lymphocytes, neutrophils and airway epithelial cells are involved in the airway inflammation and airway hyperresponsiveness in asthma pathogenesis, resulting in extensive and variable reversible expiratory airflow limitation. However, the precise molecular mechanisms underlying the allergic immune responses, particularly immunometabolism, remains unclear. Studies have detected enhanced oxidative stress, and abnormal metabolic progresses of glycolysis, fatty acid and amino acid in various immune cells, inducing dysregulation of innate and adaptive immune responses in asthma pathogenesis. Immunometabolism mechanisms contain multiple signalling pathways, providing novel therapy targets for asthma. This review summarises the current knowledge on immunometabolism reprogramming in asthma pathogenesis, as well as potential therapy strategies.