bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generating large volumes of crust-derived high δ18O rhyolites in the Chon Aike Silicic Large Igneous Province, Patagonia
Authors: Foley Michelle L. , Putlitz Benita , Baumgartner Lukas P. , Bégué Florence , Siron Guillaume , Kosmal Andres 
Published: May 2023

Abstract
The Jurassic Chon Aike Silicic Large Igneous Province (Patagonia and the Antarctic Peninsula) is dominated by voluminous, crust-derived magmas (235,000 km3) that erupted as predominately explosive silicic material over ~40 m.y. In this study, we combine petrological descriptions and bulk-rock major- and trace-element compositions with quartz oxygen-isotope measurements from multiple silicic units (primarily ignimbrites and some rhyolitic flows) from two of the five silicic formations in Patagonia. We have identified that quartz oxygen-isotope values are high (&gt;9‰–12‰). Quartz pheno crysts analyzed by secondary ion mass spectroscopy (SIMS) are also homogeneous at the microscale with no measurable change in isotope value with respect to internal and often complex zoning textures. The ubiquity of widespread high δ18O rhyolites and their trace-element compositions support their origin from melting of a metasedimentary source with a similarly high δ18O value. Mass balance calculations require that an average of &gt;75% melt derived from partial melting of the dominant basement lithology is needed to explain the isotopic and chemical composition of the rhyolites. The ideal P-T environment was identified by thermodynamic models for fluid-absent melting of graywackes at 900 °C and 5 kbar. Regional-scale crustal melting occurred during a widespread, high heat-flux environment within an extensional setting during the breakup of the Gondwanan supercontinent. The overlap of a unique tectonic and igneous environment, combined with a fertile crust dominated by graywacke and pelitic compositions in southern Patagonia, generated large volumes of some of the highest δ18O silicic magmas documented in the geologic record.
Care coordination across healthcare systems: development of a research agenda, implications for practice, and recommendations for policy based on a modified Delphi panel
Authors: Hempel Susanne , Ganz David , Saluja Sonali , Bolshakova Maria , Kim Timothy , Turvey Carolyn , Cordasco Kristina , Basu Aashna , Page Tonya , Mahmood Reshma , Motala Aneesa , Barnard Jenny , Wong Michelle , Fu Ning , Miake-Lye Isomi M 
Published: May 2023

ObjectiveFor large, integrated healthcare delivery systems, coordinating patient care across delivery systems with providers external to the system presents challenges. We explored the domains and requirements for care coordination by professionals across healthcare systems and developed an agenda for research, practice and policy.DesignThe modified Delphi approach convened a 2-day stakeholder panel with moderated virtual discussions, preceded and followed by online surveys.SettingThe work addresses care coordination across healthcare systems. We introduced common care scenarios and differentiated recommendations for a large (main) healthcare organisation and external healthcare professionals that contribute additional care.ParticipantsThe panel composition included health service providers, decision makers, patients and care community, and researchers. Discussions were informed by a rapid review of tested approaches to fostering collaboration, facilitating care coordination and improving communication across healthcare systems.Outcome measuresThe study planned to formulate a research agenda, implications for practice and recommendations for policy.ResultsFor research recommendations, we found consensus for developing measures of shared care, exploring healthcare professionals’ needs in different care scenarios and evaluating patient experiences. Agreed practice recommendations included educating external professionals about issues specific to the patients in the main healthcare system, educating professionals within the main healthcare system about the roles and responsibilities of all involved parties, and helping patients better understand the pros and cons of within-system and out-of-system care. Policy recommendations included supporting time for professionals with high overlap in patients to engage regularly and sustaining support for care coordination for high-need patients.ConclusionsRecommendations from the stakeholder panel created an agenda to foster further research, practice and policy innovations in cross-system care coordination.
Development of the Young Disability Questionnaire (spine) for children with spinal pain: field testing in Danish school children
Authors: Lauridsen Henrik Hein , Meldgaard Emilie , Hestbæk Lise , Hansen Gabrielle Kristine 
Published: May 2023

ObjectiveThe objective of this study was to finalise the development of the Young Disability Questionnaire (YDQ-spine) to measure the consequences of neck, midback and low back pain, relevant for schoolchildren aged 9–12 years.DesignA cross-sectional field test of the YDQ-spine was carried out.SettingDanish primary schools.ParticipantsChildren aged 9–12 years from all Danish schools were invited to complete the questionnaire.MethodsEight hundred and seventy-three schools were invited to participate. Consenting schools received information material, instructions and a link to an electronic version of the prefinal YDQ-spine. Local teachers distributed the electronic YDQ-spine to children aged 9–12 years. Descriptive statistics and item characteristics were carried out. Item reduction was performed using partial interitem correlations (scrutinising correlations>0.3) and factor analyses (items loading>0.3 were retained) to eliminate redundant items and to obtain insight into the structure of the questionnaire.ResultsA total of 768 children from 20 schools answered of the questionnaire and 280 fulfilled the inclusion criteria of having back and/or neck pain (36%). Multisite pain was reported by 38%. Partial interitem correlations and factor analyses resulted in elimination of four items which were considered redundant leaving 24 items in the final YDQ-spine with an optional section onwhat matters mostto the child. The factor analyses showed a two-factor structure with a physical component (13 items) and a psychosocial component (10 items) in addition to one standalone item (sleep).ConclusionThe YDQ-spine is a novel questionnaire with satisfactory content validity measuring physical and psychosocial components (including sleep disturbances) of spinal pain in children aged 9–12 years. It also offers an optional section onwhat matters mostto the child allowing targeted care in clinical practice.
Determinants of inappropriate antibiotic prescription in primary care in developed countries with general practitioners as gatekeepers: a systematic review and construction of a framework
Authors: Sijbom Martijn , Büchner Frederike L , Saadah Nicholas H , Numans Mattijs E , de Boer Mark G J 
Published: May 2023

ObjectivesThis study aimed to identify determinants of inappropriate antibiotic prescription in primary care in developed countries and to construct a framework with the determinants to help understand which actions can best be targeted to counteract development of antimicrobial resistance (AMR).DesignA systematic review of peer-reviewed studies reporting determinants of inappropriate antibiotic prescription published through 9 September 2021 in PubMed, Embase, Web of Science and the Cochrane Library was performed.SettingAll studies focusing on primary care in developed countries where general practitioners (GPs) act as gatekeepers for referral to medical specialists and hospital care were included.ResultsSeventeen studies fulfilled the inclusion criteria and were used for the analysis which identified 45 determinants of inappropriate antibiotic prescription. Important determinants for inappropriate antibiotic prescription were comorbidity, primary care not considered to be responsible for development of AMR and GP perception of patient desire for antibiotics. A framework was constructed with the determinants and provides a broad overview of several domains. The framework can be used to identify several reasons for inappropriate antibiotic prescription in a specific primary care setting and from there, choose the most suitable intervention(s) and assist in implementing them for combatting AMR.ConclusionsThe type of infection, comorbidity and the GPs perception of a patient’s desire for antibiotics are consistently identified as factors driving inappropriate antibiotic prescription in primary care. A framework with determinants of inappropriate antibiotic prescription may be useful after validation for effective implementation of interventions for decreasing these inappropriate prescriptions.PROSPERO registration numberCRD42023396225.
Online survey and interview evaluation to explore the use of video consulting among Allied Health Professionals during the COVID-19 pandemic
Authors: Williams Jessica , Johns Gemma , Phipps Kerrie , Khalil Sara , Ogonovsky Mike , Ahuja Alka 
Published: May 2023

ObjectivesAllied Health Professionals (AHP) consist of 13 different specialty roles in Wales, sharing the responsibility of promoting and supporting the health and well-being of the population. During the COVID-19 pandemic, there was a shift in care provision, with the increased use of online consultations, such as those using video consultation platforms. However, this shift was associated with uncertainty and hesitancy, and, thus, to understand the usage and reasons for using video consultations, this study aimed to capture the experiences of both AHP and their patients, while investigating each role individually.ParticipantsA survey was distributed to and completed by n=8928 patients and n=4974 clinicians, all AHP were included except for orthoptists and paramedics due to ambiguities in the data. A further 86 clinicians participated in phone interviews.ResultsAll professions had a high prevention of face-to-face with the use of video consultations (68.6% overall and 81.4% of clinicians reported the prevention). However, this was lower for certain professions such as podiatrists, potentially due to the specific patient needs, such as physical assessments. Also, a range of different appointment types were being conducted, and there was a high acceptance of these alternative methods among participants. The interviews with clinicians revealed five important aspects of video consultations: the perceived benefits, the perceived challenges, technology issues and necessary improvements, clinician preference and the future of video consulting. Specifically, the future of video consulting evidenced clinicians’ desire for a blended approach to working, selecting the appropriate modality depending on the situation and patient-specific needs.ConclusionsIntegrating the traditional methods of service delivery (face-to-face), and novel, innovative ways, such as video consultations, can motivate positive transformations for the efficiency and efficacy of health and social care.
Conflict-climate-displacement: a cross-sectional ecological study determining the burden, risk and need for strategies for neglected tropical disease programmes in Africa
Authors: Kelly-Hope Louise A , Harding-Esch Emma Michèle , Willems Johan , Ahmed Fatima , Sanders Angelia M 
Published: May 2023

ObjectivesComplex challenges such as political instability, climate change and population displacement are increasing threats to national disease control, elimination and eradication programmes. The objective of this study was to determine the burden and risk of conflict-related and climate-related internal displacements and the need for strategies for countries endemic with neglected tropical diseases (NTDs).Design, setting and outcome measuresA cross-sectional ecological study was conducted including countries that are endemic with at least one of five NTDs requiring preventive chemotherapy in the African region. For each country, the number of NTDs, population size and the number and rate per 100 000 of conflict-related and natural disaster-related internal displacements reported in 2021 were classified into high and low categories and used in unison to stratify and map the burden and risk.ResultsThis analysis identified 45 NTD-endemic countries; 8 countries were co-endemic with 4 or 5 diseases and had populations classified as ‘high’ totalling >619 million people. We found 32 endemic countries had data on internal displacements related to conflict and disasters (n=16), disasters only (n=15) or conflict only (n=1). Six countries had both high conflict-related and disaster-related internal displacement numbers totalling >10.8 million people, and five countries had combined high conflict-related and disaster-related internal displacement rates, ranging from 770.8 to 7088.1 per 100 000 population. Weather-related hazards were the main cause of natural disaster-related displacements, predominately floods.ConclusionsThis paper presents a risk stratified approach to better understand the potential impact of these complex intersecting challenges. We advocate for a ‘call to action’ to encourage national and international stakeholders to further develop, implement and evaluate strategies to better assess NTD endemicity, and deliver interventions, in areas at risk of, or experiencing, conflict and climate disasters, in order to help meet the national targets.
What proportion of clinical prediction models make it to clinical practice? Protocol for a two-track follow-up study of prediction model development publications
Authors: Arshi Banafsheh , Wynants Laure , Rijnhart Eline , Reeve Kelly , Cowley Laura Elizabeth , Smits Luc J 
Published: May 2023

IntroductionIt is known that only a limited proportion of developed clinical prediction models (CPMs) are implemented and/or used in clinical practice. This may result in a large amount of research waste, even when considering that some CPMs may demonstrate poor performance. Cross-sectional estimates of the numbers of CPMs that have been developed, validated, evaluated for impact or utilized in practice, have been made in specific medical fields, but studies across multiple fields and studies following up the fate of CPMs are lacking.Methods and analysisWe have conducted a systematic search for prediction model studies published between January 1995 and December 2020 using the Pubmed and Embase databases, applying a validated search strategy. Taking random samples for every calendar year, abstracts and articles were screened until a target of 100 CPM development studies were identified. Next, we will perform a forward citation search of the resulting CPM development article cohort to identify articles on external validation, impact assessment or implementation of those CPMs. We will also invite the authors of the development studies to complete an online survey to track implementation and clinical utilization of the CPMs.We will conduct a descriptive synthesis of the included studies, using data from the forward citation search and online survey to quantify the proportion of developed models that are validated, assessed for their impact, implemented and/or used in patient care. We will conduct time-to-event analysis using Kaplan-Meier plots.Ethics and disseminationNo patient data are involved in the research. Most information will be extracted from published articles. We request written informed consent from the survey respondents. Results will be disseminated through publication in a peer-reviewed journal and presented at international conferences.OSF registration(https://osf.io/nj8s9).
Regional and temporal trends of falls and injurious falls among Chinese older adults: results from China Health and Retirement Longitudinal Study, 2011–2018
Authors: Liu Yang , Kabba John Alimamy , Xu Sen , Gu Hanxin , Su Xiaoming , Liu Yuanli , Yu Hao 
Published: May 2023

ObjectiveThis study aimed to investigate temporal trends and regional differences of both falls and injurious falls among Chinese older adults and identify the associated risk factors.MethodsWe conducted a retrospective analysis using the 2011, 2013, 2015 and 2018 waves of China Health and Retirement Longitudinal Study. Our sample included 35 613 people aged 60 years or above. We analysed two binary outcome variables that were collected at each wave, including whether a respondent had any falls in the last 2 or 3 years, and if so, whether a respondent experienced any injurious falls that warranted seeking medical treatment. The explanatory variables included individual-level sociodemographic characteristics, physical function and health status. We conducted both descriptive and multivariate logistic analyses.ResultsWe found no significant trend for falls after adjusting for individual-level factors, while significant regional variations in falls existed with higher fall prevalence in the central and western areas, compared with the eastern area. We detected a significant descending trend of injurious falls between 2011 and 2018 and identified the northeastern region with the lowest rates of injurious falls during the study period. Our study also revealed significant risk factors for falls and injurious falls, such as chronic conditions and function limitations.ConclusionsOur results indicated no temporal trend of falls, a declined trend of injurious falls, and significant regional variations in the prevalence of falls and injurious falls in 2011–2018. These findings have important implications for prioritising areas and subpopulations to prevent falls and injuries among China’s elderly population.
Contractile function of fasting and digesting broad-snouted caiman (Caiman latirostris)
Authors: Lopes André Guelli , Monteiro Diana Amaral , Vasconcelos Eliton da Silva , Kalinin Ana Lúcia 
Published: May 2023

Feeding regimes are a critical process to ensure survival and reproduction, which modulate several behavioral and physiological patterns of ectotherms, especially cardiovascular adjustments. However, crocodilian myocardial contractile function after food intake remains understudied. We investigated the importance of ventricular myocardial contractility during digestion in the broad-snouted caiman, Caiman latirostris Daudin, 1801. Isometric ventricle preparations and Ca2+-handling protein expression were used to investigate the effects of prolonged fasting (30 days) and feeding (48 h after feeding on meals at 15% of body mass) on cardiac function. Upon feeding, there was no significant difference in relative ventricular mass. The cardiac response of the caiman to digestion was characterized by upregulation of the Na+/Ca2+ exchanger expression and an increase in myocardial contractility (positive inotropism and lusitropism) within the physiological range of heart rate. The digesting caiman's ventricular myocardium was able to maintain faster kinetics of contraction and relaxation, allowing for significantly increased cardiac pumping capacity at higher pacing frequencies. Our results demonstrated that the myocardium of broad-snouted caimans exhibits specializations in excitation–contraction coupling, which can provide a means to support high cardiovascular performance during digestion.
Hawking temperature as the total Gauss–Bonnet invariant of the region outside a black hole
Authors: Altas Emel , Tekin Bayram 
Published: May 2023

AbstractWe provide two novel ways to compute the surface gravity ($$\kappa $$
κ
) and the Hawking temperature $$(T_{H})$$

(

T
H

)

of a stationary black hole: in the first method $$T_{H}$$

T
H

is given as the three-volume integral of the Gauss–Bonnet invariant (or the Kretschmann scalar for Ricci-flat metrics) in the total region outside the event horizon; in the second method it is given as the surface integral of the Riemann tensor contracted with the covariant derivative of a Killing vector on the event horizon. To arrive at these new formulas for the black hole temperature (and the related surface gravity), we first construct a new differential geometric identity using the Bianchi identity and an antisymmetric rank-2 tensor, valid for spacetimes with at least one Killing vector field. The Gauss–Bonnet tensor and the Gauss–Bonnet scalar play a particular role in this geometric identity. We calculate the surface gravity and the Hawking temperature of the Kerr and the extremal Reissner–Nordström holes as examples.
A Holistic Presentation of 3-Electrode Potentiostat Measurement Data: The Hexa-Region Plot
Authors: Siegl Inge , Sailer Norbert , Steffan Christoph 
Published: May 2023

There is no standardizedpractice for presenting compliance voltage data generated during a 3-electrode potentiostatic measurement. As a result, engineers are sometimes unaware about the electrical requirements their sensor or cell inhibits. This paper proposes a method to compactly display all electrical information . The introduction of a six region voltage plot, with the cell current plotted in the third dimension, achieves a holistic potentiostat data presentation. The proposed method revealscompliance voltage demands, fosters understanding of a sensor’s electric behavior, enables a comparison of potentiostat capabilities, and most importantly, standardizes results across potentiostat platforms.
Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Authors: Mohammed Sabira , Thadathil Nidheesh , Ohene-Marfo Phoebe , Tran Albert L. , Van Der Veldt Michael , Georgescu Constantin , Oh Sangphil , Nicklas Evan H. , Wang Dawei , Haritha Nair Hariprasad , Luo Wenyi , Janknecht Ralf , Miller Benjamin F. , Wren Jonathan D. , Freeman Willard M. , Deepa Sathyaseelan S. 
Published: May 2023

Abstract

Nonalcoholic fatty liver disease (NAFLD) is one of the etiologies that contribute to hepatocellular carcinoma (HCC), and chronic inflammation is one of the proposed mediators of HCC. Because necroptosis is a cell death pathway that induces inflammation, we tested whether necroptosis-induced inflammation contributes to the progression of NAFLD to HCC in a mouse model of diet-induced HCC. Male and female wild-type (WT) mice and mouse models where necroptosis is blocked (Ripk3−/− or Mlkl−/− mice) were fed either a control diet, choline-deficient low-fat diet or choline-deficient high-fat diet. Blocking necroptosis reduced markers of inflammation [proinflammatory cytokines (TNFα, IL6, and IL1β), F4/80+ve macrophages, CCR2+ve infiltrating monocytes], inflammation-associated oncogenic pathways (JNK, PD-L1/PD-1, β-catenin), and HCC in male mice. We demonstrate that hepatic necroptosis promotes recruitment and activation of liver macrophages leading to chronic inflammation, which in turn trigger oncogenic pathways leading to the progression of NAFLD to HCC in male mice. Whereas in female mice, blocking necroptosis reduced HCC independent of inflammation. Our data show a sex-specific difference in the development of inflammation, fibrosis, and HCC in WT mice. However, blocking necroptosis reduced HCC in both males and females without altering liver fibrosis. Thus, our study suggests that necroptosis is a valid therapeutic target for NAFLD-mediated HCC.

Implications:
Necroptosis is a major contributor to hepatic inflammation that drives the progression of NAFLD to HCC and therefore represents a valid target for NAFLD-mediated HCC.