bluuebunny/crossref_metadata_2025_split huggingface dataset:
How different augmented reality visualizations for drilling affect trajectory deviation, visual attention, and user experience
Authors: Wolf Julian , Luchmann Dietmar , Lohmeyer Quentin , Farshad Mazda , Fürnstahl Philipp , Meboldt Mirko 
Published: February 2023

Abstract
Purpose
Previous work has demonstrated the high accuracy of augmented reality (AR) head-mounted displays for pedicle screw placement in spinal fusion surgery. An important question that remains unanswered is how pedicle screw trajectories should be visualized in AR to best assist the surgeon.

Methodology
We compared five AR visualizations displaying the drill trajectory via Microsoft HoloLens 2 with different configurations of abstraction level (abstract or anatomical), position (overlay or small offset), and dimensionality (2D or 3D) against standard navigation on an external screen. We tested these visualizations in a study with 4 expert surgeons and 10 novices (residents in orthopedic surgery) on lumbar spine models covered by Plasticine. We assessed trajectory deviations ($$^\circ $$

∘

) from the preoperative plan, dwell times (%) on areas of interest, and the user experience.

Results
Two AR visualizations resulted in significantly lower trajectory deviations (mixed-effects ANOVA, p<0.0001 and p<0.05) compared to standard navigation, whereas no significant differences were found between participant groups. The best ratings for ease of use and cognitive load were obtained with an abstract visualization displayed peripherally around the entry point and with a 3D anatomical visualization displayed with some offset. For visualizations displayed with some offset, participants spent on average only 20% of their time examining the entry point area.

Conclusion
Our results show that real-time feedback provided by navigation can level task performance between experts and novices, and that the design of a visualization has a significant impact on task performance, visual attention, and user experience. Both abstract and anatomical visualizations can be suitable for navigation when not directly occluding the execution area. Our results shed light on how AR visualizations guide visual attention and the benefits of anchoring information in the peripheral field around the entry point.
Does the combination of sustainable business model patterns lead to truly sustainable business models? Critical analysis of existing frameworks and extensions
Authors: Abdelkafi Nizar , Xu Jinou , Pero Margherita , Ciccullo Federica , Masi Antonio 
Published: February 2023

AbstractBusiness models can be created by combining business model patterns. The use of patterns can stimulate creativity of entrepreneurs and support the design of innovative business models for sustainability. In this article, we analyze the frameworks on sustainable business model (SBM) patterns, which can be mainly classified along the three dimensions of the triple bottom line (TBL): economic, environmental, and social. Furthermore, we introduce the concept of “truly sustainable business models” by drawing on contingency and system theory. We observe that the simple application of the frameworks of business model patterns by combining economic, environmental, and social business model patterns for sustainability into one single business model does not necessarily lead to a truly sustainable business model. Therefore, the combination of patterns along the TBL seems a necessary, but not sufficient condition for achieving true sustainability, and hence, the mere reliance on SBM patterns in business model design can be misleading to entrepreneurs. Our conceptual work advances research related to frameworks on SBM patterns by identifying three critical levels for the analysis of whether a business model is truly sustainable or not. The first level is inherent to the business model as a system; the second is related to the larger system, in which the business model is embedded; and the third is about the contingency factors that can impact the sustainability effectiveness of the business model over time.
Inter- und Transdisziplinarität als normative Dynamik: Herausforderungen und Chancen für die Politikwissenschaft
Authors: Graf Antonia , Loges Bastian , Schwindenhammer Sandra 
Published: February 2023

ZusammenfassungDie Inter- und Transdisziplinarität (ITD) hält seit längerer Zeit Einzug in die Politikwissenschaft und obgleich diese sich regelmäßig mit ihrem Selbstverständnis auseinandersetzt, sind die Konsequenzen von ITD für Forschung und Forschende bislang noch nicht systematisch betrachtet worden. Um Impulse für diese Debatte zu setzen, konzeptualisieren wir ITD als Spektrum zwischen Wissensintegration, Anwendungsbezug und Beteiligung. Wir nutzen die Normenforschung der Internationalen Beziehungen (IB) als theoretischen Referenzrahmen, um die ITD als normative Dynamik zu beschreiben, zu analysieren und zu reflektieren. Autoethnografisch und mittels teilnehmender Beobachtung untersuchen wir ITD als normative Dynamik anhand von drei Forschungsprojekten im Bereich der Nachhaltigkeit. Konkret fragen wir, welche Implikationen die ITD für Forschende und Forschung in der Politikwissenschaft hat. Im Ergebnis zeigt sich, dass ITD sowohl Chancen als auch Herausforderungen bietet. Vor dem Hintergrund der Wissensintegration diskutieren wir die Bedeutung einer an den großen gesellschaftlichen Fragen teilhabenden Politikwissenschaft im Kontrast zu den Präferenzen der ITD für ein bestimmtes Wissens- und Forschungsverständnis. Den Anwendungsbezug der ITD reflektieren wir im Hinblick auf die Möglichkeiten zur Problemlösung und Outputorientierung. Zudem betrachten wir das Teilhabepostulat der ITD und wägen potenzielle demokratisierende Effekte mit den Bedingungen ab, unter denen diese realisiert werden könnten. Abschließend gehen wir darauf ein, wo weitere Forschung sinnvoll erscheint, um die Reflexion über ITD weiter fortzuschreiben.
Is the EU shirking responsibility for its deforestation footprint in tropical countries? Power, material, and epistemic inequalities in the EU’s global environmental governance
Authors: Kumeh Eric Mensah , Ramcilovic-Suominen Sabaheta 
Published: February 2023

AbstractThis paper critically examines the European Union’s (EU) role in tropical deforestation and the bloc’s actions to mitigate it. We focus on two EU policy communications aimed at the challenge: stepping up EU action to protect and restore the world's forests and the EU updated bioeconomy strategy. In addition, we refer to the European Green Deal, which articulates the bloc’s overarching vision for sustainability and transformations. We find that by casting deforestation as a production problem and a governance challenge on the supply side, these policies deflect attention from some of the key drivers of tropical deforestation—the EU’s overconsumption of deforestation-related commodities and asymmetric market and trade power relations. The diversion allows the EU unfettered access to agro-commodities and biofuels, which are important inputs to the EU’s green transition and bio-based economy. Upholding a ‘sustainability image’ within the EU, an overly business-as-usual approach has taken precedence over transformative policies, enabling multinational corporations to run an ecocide treadmill, rapidly obliterating tropical forests. Whereas the EU's plan to nurture a bioeconomy and promote responsible agro-commodities production in the global South are relevant, the bloc is evasive in setting firm targets and policy measures to overcome the inequalities that spring from and enable its overconsumption of deforestation-related commodities. Drawing on degrowth and decolonial theories, we problematise the EU’s anti-deforestation policies and highlight alternative ideas that could lead to more just, equitable and effective measures for confronting the tropical deforestation conundrum.
A Novel Approach to Analysis of Complex Crystallization Behavior in Zr-Based Bulk Metallic Glass by Non-isothermal Kinetics Studies
Authors: Biały Michał , Hasiak Mariusz , Łaszcz Amadeusz 
Published: February 2023

AbstractThe complex crystallization behavior of the Zr40Ti15Cu10Ni10Be25 bulk metallic glass (BMG) produced by suction-casting method was studied with the non-isothermal DSC measurements with the heating rate from 5 to 40 K/min. Three exothermic phenomena were observed for the investigated material. The novel evaluation procedure for qualitative and quantitative analysis of intricate crystallization kinetics for Zr-based BMGs is proposed. The unusual deconvolution of the DSC curves based on a Gaussian function and a two-phase exponential decay function allowed for separate, detailed analysis of overlapped peaks. The activation energies for each crystallization stage were studied based on overall (Kissinger) and local (Kissinger–Akahira–Sunose) procedures. The KAS method applied separately for both low and high heating rates showed a significant difference in local activation energies. Finally, the local Avrami exponent evaluation revealed that the first two stages of crystallization are diffusion-controlled with mainly increasing nucleation rate, whereas the third crystallization is more growth-dominated.
Prevalence and correlates of restrictive interventions in an Irish child and adolescent psychiatric unit: a 4-year retrospective study
Authors: Haran Maeve , Killeen David , Healy Mike , Brophy Peadar , Donohue Aoife , Whyte Imelda , Doody Brendan 
Published: February 2023

Abstract
Background
There has been a global effort to reduce the use of restrictive interventions (RIs) in healthcare settings. In order to reduce unnecessary RIs, it is essential to understand their use in mental health settings. To date, there have been few studies examining the use of RIs in child and adolescent mental health settings, with no such studies in Ireland.

Aims
The purpose of this study is to examine the prevalence and frequency of physical restraints and seclusion and to identify any associated demographic and clinical characteristics.

Methods
This is a 4-year retrospective study of the use of seclusion and physical restraint in an Irish child and adolescent psychiatric inpatient unit from 2018 to 2021. Computer-based data collection sheets and patient records were retrospectively reviewed. Eating disorder and non-eating disorder samples were analysed.

Results
Of 499 hospital admissions from 2018 to 2021, 6% (n = 29) had at least one episode of seclusion and 18% (n = 88) had at least one episode of physical restraint. Age, gender and ethnicity were not significantly associated with rates of RI. Unemployment, prior hospitalization, involuntary legal status and longer length of stay were significantly associated with higher rates of RIs in the non-eating disorder group. Involuntary legal status was associated with higher rates of physical restraint in the eating disorder group. Patients with a diagnosis of eating disorder and psychosis had the highest prevalence of physical restraints and seclusions respectively.

Conclusions
Identifying youth who are at greater risk of requiring RIs may allow early and targeted intervention and prevention.
Personality Profiles of Royal Canadian Mounted Police Cadets Starting the Cadet Training Program
Authors: Andrews Katie L. , Jamshidi Laleh , Nisbet Jolan , Teckchandani Taylor A. , Afifi Tracie O. , Sauer-Zavala Shannon , Krätzig Gregory P. , Carleton R. Nicholas 
Published: February 2023

AbstractPersonalities of those entering the Royal Canadian Mounted Police (RCMP) Cadet Training Program (CTP) are unknown and may differ to the general public. The current study provides the first known detailed analyses of personality trait, sociodemographic, and gender differences among RCMP cadets. The current study draws data from the RCMP Longitudinal PTSD Study (www.rcmpstudy.ca). Participating RCMP cadets (n = 772) starting the CTP completed a web-based questionnaire which included sociodemographic questions and the six-factor HEXACO personality inventory. Cadet women reported significantly higher scores on the HEXACO factors of Honesty-Humility, Emotionality, and Conscientiousness and lower scores on Agreeableness and Openness to Experience than cadet men. Older cadets (+ 40 years old) and cadets with more education (university degree or higher) also scored significantly higher on all factor-level scales, except for Extraversion. Relative to the general population, participating cadets reported significantly higher levels of Honesty-Humility, Extraversion, Agreeableness, and Conscientiousness and lower levels of Emotionality and Openness to Experience. Cadets also reported significantly higher scores on the HEXACO facet-level scales of Fairness and lower scores on Fearfulness and Unconventionality. The current results highlight potentially important HEXACO factor-level and facet-level differences between cadet men and women and between the general population and RCMP cadets.
Sex differences in the diagnosis, treatment and prognosis of cancer: the rationale for an individualised approach
Authors: Vera Ruth , Juan-Vidal Oscar , Safont-Aguilera María José , de la Peña Francisco Ayala , del Alba Aránzazu González 
Published: February 2023

Abstract
Background
Precision medicine in oncology aims to identify the most beneficial interventions based on a patient’s individual features and disease. However, disparities exist when providing cancer care to patients based on an individual’s sex.

Objective
To discuss how sex differences impact the epidemiology, pathophysiology, clinical manifestations, disease progression, and response to treatment, with a focus on data from Spain.

Results
Genetic and environmental factors (social or economic inequalities, power imbalances, and discrimination) that contribute to these differences adversely affect cancer patient health outcomes. Increased health professional awareness of sex differences is essential to the success of translational research and clinical oncological care.

Conclusions
The Sociedad Española de Oncología Médica created a Task Force group to raise oncologists’ awareness and to implement measures to address sex differences in cancer patient management in Spain. This is a necessary and fundamental step towards optimizing precision medicine that will benefit all individuals equally and equitably.
Inxeba: Rethinking Dichotomies of Black Queer Visibilities
Authors: Livermon Xavier 
Published: February 2023

Abstract
In this commentary, I read the recent film Inxeba alongside Andrew Tucker’s Queer Visibilities in order to ask questions about dichotomies, the space of the rural, and the framework of visibilities for thinking through African Queer urban practices. I suggest that a careful attention to the representational practices of a film like Inxeba requires us to think in more nuanced ways about Urban African sexualities.
Wild and Indigenous Foods (WIF) and Urban Food Security in Northern Namibia
Authors: Nickanor Ndeyapo M. , Kazembe Lawrence N. , Crush Jonathan S. 
Published: February 2023

Abstract
Rapid urbanisation and food system transformation in Africa have been accompanied by growing food insecurity, reduced dietary diversity, and an epidemic of non-communicable disease. While the contribution of wild and indigenous foods (WIF) to the quality of rural household diets has been the subject of longstanding attention, research on their consumption and role among urban households is more recent. This paper provides a case study of the consumption of WIF in the urban corridor of northern Namibia with close ties to the surrounding rural agricultural areas. The research methodology involved a representative household food security survey of 851 urban households using tablets and ODK Collect. The key methods for data analysis included descriptive statistics and ordinal logistic regression. The main findings of the analysis included the fact that WIFs are consumed by most households, but with markedly different frequencies. Frequent consumers of WIF are most likely to be female-centred households, in the lowest income quintiles, and with the highest lived poverty. Frequent consumption is not related to food security, but is higher in households with low dietary diversity. Infrequent or occasional consumers tend to be higher-income households with low lived poverty and higher levels of food security. We conclude that frequent consumers use WIF to diversify their diets and that occasional consumers eat WIF more for reasons of cultural preference and taste than necessity. Recommendations for future research include the nature of the supply chains that bring WIF to urban consumers, intra-household consumption of WIF, and in-depth interviews about the reasons for household consumption of WIF and preferences for certain types of wild food.
Smaller Cerebellar Lobule VIIb is Associated with Tremor Severity in Parkinson’s Disease
Authors: Sadeghi Fatemeh , Pötter-Nerger Monika , Grimm Kai , Gerloff Christian , Schulz Robert , Zittel Simone 
Published: February 2023

AbstractAlterations
in the cerebellum’s morphology in Parkinson’s disease (PD) point to its pathophysiological involvement in this movement disorder. Such abnormalities have previously been attributed to different PD motor subtypes. The aim of the study was to relate volumes of specific cerebellar lobules to motor symptom severity, in particular tremor (TR), bradykinesia/rigidity (BR), and postural instability and gait disorders (PIGD) in PD. We performed a volumetric analysis based on T1-weighted MRI images of 55 participants with PD (22 females, median age 65 years, Hoehn and Yahr stage 2). Multiple regression models were fitted to investigate associations between volumes of cerebellar lobules with clinical symptom severity based on MDS-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) part III score and sub-scores for TR, BR, and PIGD; adjusted for age, sex, disease duration, and intercranial volume as cofactors. Smaller volume of lobule VIIb was associated with higher tremor severity (P = 0.004). No structure–function relationships were detected for other lobules or other motor symptoms. This distinct structural association denotes the involvement of the cerebellum in PD tremor. Characterizing morphological features of the cerebellum leads to a better understanding of its role in the spectrum of motor symptoms in PD and contributes further to identifying potential biological markers.
Different Silicon Application Sources and Factors Influencing Mandibular Wear in Sugarcane Early Shoot Borer, Chilo infuscatellus Walker
Authors: Veeran Sivakumar Indhumathi , Periyakaman Chandramani , Peyandi Paraman Mahendran , Jayachandran Jayaraj 
Published: February 2023

AbstractSilicon (Si) can improve plant resistance to herbivorous insect attack. Early shoot borer (ESB), is one of the most solemn lepidopterans borers on sugarcane in India. Even with insecticide application, management of this pest is difficult. The management requires a fresh new approach. As a result, the current study aims to determine the effect of silicon on the early shoot borer, Chilo infuscatellus Walker, through biophysical factor analysis and mandibular wear documentation. When sugarcane leaves were treated with calcium silicate at 1000 kg/ha, scanning electron microscopy revealed the presence of silicified cells and trichomes, as well as increased cell wall thickness, silicon content, and waxes content. Furthermore, larvae of an early shoot borer fed silica-treated plants showed a complete wearing of mandibles as compared to untreated check.
Carbon nanotubes as a suitable material for electrochemical sensor used in voltammetric determinations of titanium
Authors: Grabarczyk Malgorzata , Wlazłowska Edyta , Adamczyk Marzena 
Published: February 2023

AbstractWe report the use of carbon nanotubes as a material for the preparation of an electrochemical sensor that acts as a substrate for film metal electrodes used in stripping voltammetry. The sensor is based on a mixture of multiwall carbon nanotubes, glassy carbon spherical powder, and epoxy resin. The properly selected composition of the sensor made it possible to obtain a new substrate, competitive in relation to glassy carbon, for creating film metal electrodes. In this work, the proposed new sensor was used to determine the trace amounts of Ti(IV) on the lead film electrode. Measurements were carried out with in situ mode in an acetate buffer by adsorption stripping voltammetry with the use of cupferron as a complexing agent. Linear response to Ti(IV) ions in the concentration range of 7 × 10–10–7 × 10–8 mol L−1 and the limit of detection (LODs) 2.4 × 10–10 were obtained, respectively. These promising results revealed that a mixture of carbon nanotubes, epoxy resin, and spherical glassy carbon powder used for the determination of titanium ions on PbFE might represent an important addition to existing electrochemical sensor technologies. The proposed procedure was successfully used as a new and powerful analytical tool for determination of Ti(IV) in horsetail extracts.
Tumor-associated macrophage-derived GDNF promotes gastric cancer liver metastasis via a GFRA1-modulated autophagy flux
Authors: Ni Bo , He Xuan , Zhang Yeqian , Wang Zeyu , Dong Zhongyi , Xia Xiang , Zhao Gang , Cao Hui , Zhu Chunchao , Li Qing , Liu Jiahua , Chen Huimin , Zhang Zizhen 
Published: February 2023

Abstract
Purpose
Liver metastasis, a lethal malignancy of gastric cancer (GC) patients, execrably impairs their prognosis. As yet, however, few studies have been designed to identify the driving molecules during its formation, except screening evidence pausing before their functions or mechanisms. Here, we aimed to survey a key driving event within the invasive margin of liver metastases.

Methods
A metastatic GC tissue microarray was used for exploring malignant events during liver-metastasis formation, followed by assessing the expression patterns of glial cell-derived neurotrophic factor (GDNF) and GDNF family receptor alpha 1 (GFRA1). Their oncogenic functions were determined by both loss- and gain-of-function studies in vitro and in vivo, and validated by rescue experiments. Multiple cell biological studies were performed to identify the underlying mechanisms.

Results
In the invasive margin, GFRA1 was identified as a pivotal molecule involved in cellular survival during liver metastasis formation, and we found that its oncogenic role depends on tumor associated macrophage (TAM)-derived GDNF. In addition, we found that the GDNF-GFRA1 axis protects tumor cells from apoptosis under metabolic stress via regulating lysosomal functions and autophagy flux, and participates in the regulation of cytosolic calcium ion signalling in a RET-independent and non-canonical way.

Conclusion
From our data we conclude that TAMs, homing around metastatic nests, induce the autophagy flux of GC cells and promote the development of liver metastasis via GDNF-GFRA1 signalling. This is expected to improve the comprehension of metastatic pathogenesis and to provide a novel direction of research and translational strategies for the treatment of metastatic GC patients.
Eosinofiele cystitis
Authors: van den Ouden Dies 
Published: February 2023

SamenvattingEosinofiele cystitis (EC) is een zeldzame vorm van blaasontsteking die wordt gekenmerkt door ontsteking met infiltratie van eosinofiele granulocyten in alle lagen van de blaaswand. De incidentie en epidemiologie zijn onbekend. Voornaamste etiologische factoren zijn allergische aanleg en trauma (operatie/instrumentatie) van de blaas. De diagnostiek bestaat uit cystoscopie en biopten van de blaaswand, urine- en bloedonderzoeken, aangevuld met een echo van de nieren om obstructie (dilatatie) van de hoge urinewegen uit te sluiten. Als therapie worden corticosteroïden gecombineerd met antihistaminica en NSAID’s gebruikt, en bij therapieresistentie IL‑5 remmers. In het laatste geval of bij recidieven kunnen meerdere opeenvolgende behandelingen noodzakelijk zijn, met als laatste stap cystectomie.