bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Montelukast combined with Sublingual Immunotherapy in the treatment of children with Obstructive Sleep Apnea Hypopnea Syndrome Complicated with allergic rhinitis
Authors: Mao Xiuhua , Zhao Wenjuan 
Published: July 2023

Objective: To observe the efficacy of Montelukast combined with sublingual immunotherapy (SLIT) in the treatment of children with obstructive sleep apnea hypopnea syndrome (OSAHS) complicated with allergic rhinitis (AR).
Methods: This is a prospective study. A total of 102 children with OSAHS complicated with allergic rhinitis admitted to Hunan Children’s Hospital from April 2020 to April 2021 were selected and randomly divided into two groups: sublingual group and two-drug combination group. Children in the sublingual group were treated with standardized dust mite drops Nos. 1-4 for SLIT, while those in the two-drug combination group were treated with Montelukast on top of the sublingual group. Statistical analysis and comparison were made between the two groups of children in terms of Sleep apnea hypopnea index (AHI), Hypoxic saturation (Lsao2), interleukin-4, Il-4), interleukin-17 (IL-17), OSA-18 Snoring Symptom Scale for Children (OSA-18), allergic rhinitis symptom scale (TNSS), efficacy, occurrence of adverse reactions, etc.
Results: After treatment, the AHI index of the two-drug combination group was significantly decreased, and the Lsao2 index was significantly increased compared with the sublingual group (P<0.05). Compared with the sublingual group, the levels of IL-4 and IL-17 in the two-drug combination group were significantly decreased (P<0.05), the OSA-18 score and TNSS score were significantly lower (P<0.05). Moreover, compared with the sublingual group, the efficacy of the two-drug combination group was significantly increased (P<0.05), the incidence of adverse reactions was significantly lower (P<0.05).
Conclusion: Montelukast combined with sublingual immunotherapy offers many advantages, such as effectively controlling nasal allergy symptoms in children with OSAHS complicated with allergic rhinitis and improving OSAHS symptoms.
doi: https://doi.org/10.12669/pjms.39.5.6985
How to cite this: Mao X, Zhao W. Efficacy of Montelukast combined with Sublingual Immunotherapy in the treatment of children with Obstructive Sleep Apnea Hypopnea Syndrome Complicated with allergic rhinitis. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.6985
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Epidemiology of hip & knee replacement across Pakistan according to Pakistan national joint registry: A cross-sectional study
Authors: Bukhari Syed Imran , Allana Asad Rehman , Najjad Kazim Rahim , Noor Syed Shahid 
Published: July 2023

Objective: To know about the prevalence of hip and knee arthroplasty according to Pakistan National Joint Registry (PNJR).
Methods: This is a retrospective cross-sectional study with data collection from Pakistan National Joint Registry of number of hip and knee arthroplasty cases across Pakistan in seven years (2014-2019) since inception of PNJR. Stata version 16 was used for data analysis. Mean & standard deviation was reported for quantitative variable & frequency and proportion were reported for qualitative variables.
Results: Our results showed a total of 14,875 people had total knee replacement in last seven years from 2014-2021 with the rate of 14.8/100,000 population. Mean age of the patient was 79.9±15.9 with 67.2% of patients being female and 32.7% being male. Our results showed a total of 5,167 people had total hip replacement in last seven years from 2014-2021, with the rate of 5.16/100,000 population. Mean age of the patient was 41.8±20.9 with 61.7% of patients being male and 38.3% being female.
Conclusion: This is the first epidemiological study in Pakistan on the rates of hip and knee arthroplasty cases in Pakistan based on registry data, showing that more knee arthroplasty cases are being performed as compared to hip arthroplasty.
doi: https://doi.org/10.12669/pjms.39.5.7006
How to cite this: Bukhari SI, Allana AR, Najjad KR, Noor SS . Epidemiology of hip & knee replacement across Pakistan according to Pakistan national joint registry: A cross-sectional study. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7006
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Effect of different chemotherapy schemes on early-stage breast cancer patients with Low HER-2 expression
Authors: Xu Yurui , Chao Lin , Wang Jianyu , Sun Yonghong , Li Chen 
Published: July 2023

Objective: To explore the effect of different chemotherapy schemes on the prognosis, immune function and adverse reactions of breast cancer patients with low HER-2 expression after surgery.
Methods: A retrospective analysis was carried out on the clinical data of 60 breast cancer patients with low HER-2 expression in Wuxi No.2 people’s Hospital from January 2018 to December 2019. The enrolled patients were divided into two groups according to the different chemotherapy schemes. Patients in the DC group were treated with polyethylene glycol-coated liposome-encapsulated doxorubicin+cyclophosphamide, and those in the TC group were treated with TC (docetaxel+cyclophosphamide). Further comparison was performed on the difference in prognosis, immune function and adverse reaction between the two groups after different chemotherapy schemes.
Results: After four courses of treatment, the IgG, CD4+ and CD4+/CD8+ values in the DC group after treatment were higher than those before treatment, while the IgG, CD3+ and CD4+values in the TC group after treatment were lower than those before treatment(P<0.05). Meanwhile, the IgG, CD4+ and CD4+/CD8+ values in the DC group were better than those in the TC group after treatment(P<0.05). During the treatment, the adverse reactions of leukopenia, alopecia, nausea and vomiting in the DC group were significantly lower than those in the TC group(P<0.05).
Conclusion: The chemotherapy combination of liposome-encapsulated doxorubicin+cyclophosphamide can significantly improve immune function and greatly reduce the occurrence of adverse reactions in early-stage breast cancer patients with low HER-2 expression after surgery. It has the same effect as docetaxel+cyclophosphamide in improving the prognosis of patients.
doi: https://doi.org/10.12669/pjms.39.5.7446
How to cite this: Xu Y, Chao L, Wang J, Sun Y, Li C. Effect of different chemotherapy schemes on early-stage breast cancer patients with Low HER-2 expression. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7446
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Quand Arcenel fait un tour : Praxis de la marche, poïesis de la lecture
Authors: Vinot Frédéric 
Published: July 2023

Abstract: Le treizième chapitre de 14 relate la désertion particulière d’Arcenel. Le mouvement dont elle procède se fait sans préméditation, sans intentionnalité, et sans but: il s’agit de « faire un tour ». Ce registre de l’action est d’abord référé à la praxis au sens d’Aristote (ne rien produire). De l’exécution d’Arcenel, nous montrons comment loi d’un espace bien délimité, loi d’un moi strictement identifié et loi d’une langue bien assujettie vont ensemble. Une articulation entre praxis et poïesis lisible dans l’écriture d’Echenoz est ensuite proposée. Enfin, une interprétation psychanalytique en montre l’envers inconscient: la production d’un rien, tant au niveau du tour d’Arcenel, que de sa lecture.
Integrated analysis of the microbiome and transcriptome in stomach adenocarcinoma
Authors: Zhou Daxiang , Xiong Shu , Xiong Juan , Deng Xuesong , Long Quanzhou , Li Yanjie 
Published: July 2023

Abstract
We aimed to characterize the stomach adenocarcinoma (STAD) microbiota and its clinical value using an integrated analysis of the microbiome and transcriptome. Microbiome and transcriptome data were downloaded from the Cancer Microbiome Atlas and the Cancer Genome Atlas databases. We identified nine differentially abundant microbial genera, including Helicobacter, Mycobacterium, and Streptococcus, which clustered patients into three subtypes with different survival rates. In total, 74 prognostic genes were screened from 925 feature genes of the subtypes, among which five genes were identified for prognostic model construction, including NTN5, MPV17L, MPLKIP, SIGLEC5, and SPAG16. The prognostic model could stratify patients into different risk groups. The high-risk group was associated with poor overall survival. A nomogram established using the prognostic risk score could accurately predict the 1, 3, and 5 year overall survival probabilities. The high-risk group had a higher proportion of histological grade 3 and recurrence samples. Immune infiltration analysis showed that samples in the high-risk group had a higher abundance of infiltrating neutrophils. The Notch signaling pathway activity showed a significant difference between the high- and low-risk groups. In conclusion, a prognostic model based on five feature genes of microbial subtypes could predict the overall survival for patients with STAD.
Utility of neutrophil–lymphocyte ratio and platelet–lymphocyte ratio in predicting acute-on-chronic liver failure survival
Authors: Li Dong , Sun Wei , Chen Li , Gu Jing , Wu Huichun , Xu Huayu , Gan Jianhe 
Published: July 2023

Abstract
This study explored the predictive value of the monocyte-to-lymphocyte ratio (MLR) and platelet–lymphocyte ratio (PLR) in patients with acute-on-chronic liver failure (ACLF). A retrospective analysis was carried out on 40 patients with ACLF from January 2018 and August 2019 in our hospital. The patient’s clinical information during hospitalization was collected, and their survivals were followed for 3 months. MLR and PLR values of patients were compared, and the correlation between liver function indicators and prognosis was analyzed. We observed that MLR levels in the survival and death groups were 0.521 (0.311, 0.827) and 0.741 (0.442, 1.121), respectively. MLR levels were markedly enhanced in the death group compared to the survival group (P = 0.021). The receiver operating characteristic curve (ROC) exhibited that the area under the ROC curve and 95% confidence interval for the survival group was 0.641 (0.528–0.757). Survival analysis demonstrated that the 3-month survival of the high MLR group was markedly lower than that of the low MLR group (P = 0.001). Multivariate regression exposed that MLR and PLR were independent prognostic factors for ACLF. MLR and PLR could be prospective prognosticative markers of ACLF.
Representations of Jewish Functionaries in the Holocaust in Israeli Documentary Cinema
Authors: Steir-Livny Liat 
Published: July 2023

Abstract
The role of Jewish functionaries during the Holocaust has fueled heated debates internationally, as well as in Israel since the 1940s. For decades, however, the topic was marginalized in Israeli cinema. The documentary, Kapo (Tor Ben-Mayor and Dan Setton 1999) was the first to include filmed testimonies of former Jewish female functionaries in Auschwitz-Birkenau. The documentary, We Wept Without Tears (Itai Lev and Gideon Greif 2021) is the first to include testimonies by members of the Sonderkommando (“the special squad”) i.e., prisoners in Auschwitz-Birkenau, primarily Jews, who were forced to work in the killing installations. This article analyzes the ways these documentaries deliberately suspend judgment to provide a more complex perspective on these individuals. Kapo and We Wept Without Tears are examined in the context of how Holocaust memory has changed in Israeli society and cinema. The discussion centers on the ways these films generate a non-judgmental narrative, and the similarities and differences between them in approaching this sensitive topic. It shows that Kapo endeavors to maintain cinematic ambivalence, whereas We Wept Without Tears deliberately highlights the protagonists’ lack of agency and avoids rendering judgment.
Commitment Helps: The Positive Effects of Long-Term Orientation and Family Ownership on Firms’ International Expansion
Authors: Frerich Sören , Calabrò Andrea , Torchia Mariateresa 
Published: July 2023

Abstract
This research examines how commitment, long-term orientation, and distinctive family business traits resulting from family ownership affect internationalization by studying two unique and long-lasting firms with family and non-family ownership structures. Drawing upon arguments from international business studies and family business research, we have identified various entrepreneurial motivations and derived a framework that expands our knowledge on how commitment, long-term orientation and specific differences between family and non-family firms impact their international expansion. Our results indicate that family firms generate social capital, experience, and knowledge in an international context to sustain and maximize their advantages better than non-family firms.
Characteristics of the present crustal deformation in the Tibetan Plateau and its relationship with strong earthquakes
Authors: Ma Haiping , Zhang Hui , Li Minjuan , Wu Shanyi , Wang Pengtao , Wang Qian , Zhao Jing , Ma Zhiqiang 
Published: July 2023

AbstractTo study the characteristics of the present crustal movement in the Tibetan Plateau and explore its relationship between strong earthquakes with magnitudes of 8 and above, the velocity field size was analyzed based on the global position system (GPS) campaign observations and the time series of site north-ward displacement and long baseline were discussed using the GPS continuous observations. The results show that the velocity field size in the Tibetan Plateau decreases from southwest to north, northeast, and southeast, and the value of the velocity in the west is significantly greater than that in the east in the same dimension. The maximum value is located in the southwest and the minimum value is located in the east. The Wenchuan earthquake is located in the mutation region, where the rate and the direction of the crustal movement are quite different. The crustal deformation extent is large in the region close to the seismic source before the earthquake, reflecting that the regional stress accumulation is fast and its required time is relatively short. However, the crustal deformation extent is relatively small in the region away from the seismic source before the earthquake, reflecting that the regional stress accumulation is slow and its required time is relatively long. The N-ward movement became significantly strong after NepalMS8.1 earthquake; the occurrence of this earthquake may have caused the unlocking of large-scale faults near the seismic source, which further intensified the NE-ward subduction and collision of the Indian Plate. The compression of the Indian Plate to the Tibetan Plateau slowed down after the 2008 WenchuanMS8.0 earthquake, and increased significantly after 2015, which boosted strain accumulation in the Tibetan Plateau, and attention needs to be paid continuously to strong earthquake risk in this region.
A one-pot, multicomponent tandem synthesis of fused polycyclic pyrrolo[3,2-c]quinolinone/pyrrolizino[2,3-c]quinolinone hybrid heterocycles via environmentally benign solid state melt reaction
Authors: Mani Suresh , Raju Rajesh , Arumugam Natarajan , Almansour Abdulrahman I. , Suresh Kumar Raju , Perumal Karthikeyan 
Published: July 2023

Abstract
Structurally diverse fused polycyclic pyrrolo[3,2-c]quinolinone/pyrrolizino[2,3-c]quinolinone hybrids were synthesized to get excellent yields via a tandem multi-component reaction sequence employing an environmentally benign solid state melt reaction involving [3+2]-cycloaddition process followed by two consecutive annulation steps. Baylis–Hillman products, used as dipolarophiles, were synthesized from various substituted aryl/heteroaryl aldehydes in the presence of DABCO and methyl acrylate, while the 1,3-dipole component was derived in situ from indoline-2,3-dione and acyclic/cyclic amino acid viz N-methylgylcine/l-proline. The structure of the unusual tandem products was unambiguously assigned by spectroscopic and XRD analysis. The products arose through the formation of three new rings, five new bonds, and three adjoining stereocenters with complete diastereomeric control.
Green and recyclable mesoporous silica supported WO3–ZrO2 solid acid catalyst for biodiesel production by transesterification of Ankol seed oil with methanol
Authors: Manimaran Shanmugam , Tschentscher Roman , Pandurangan Arumugam , Govindasamy Gopalakrishnan 
Published: July 2023

Abstract
Biodiesel, an important sustainable fuel used in the transportation sector, demands a stable, recyclable and green catalyst for its economical and environmentally benign production. A novel green heterogeneous acid catalyst was developed by extracting sodium silicate from bamboo leaf ash (BLA), using which SBA-16 (BLA) was synthesized and then impregnated with 10 wt% each of WO3 and ZrO2, characterized and evaluated for the transesterification of Ankol seed oil with methanol to biodiesel. XRD, SEM, TEM and pore size characterization indicated that impregnated WO3 and ZrO2 were present outside the mesopores of SBA-16 (BLA) as monoclinic phases, thus 3D cubic cage-like Im3m mesopores of SBA-16 were unaltered. NH3-TPD indicated the presence of acid sites of two distinct strengths, attributed to the Lewis and Brønsted acidity of WO3–ZrO2 impregnated into SBA-16 (BLA) and hence gave the highest biodiesel yield of 98 %. In contrast 10 wt% of WO3 and 10 wt% of ZrO2 separately impregnated into SBA-16 gave 65  and 57 % of biodiesel yield respectively, possibly due to the presence of Lewis acidity alone in them. Among the WO3(10 %)–ZrO2(10 %) impregnated mesoporous supports viz. SBA-16 (BLA), SBA-16 (synthesized using tetraethyl orthosilicate), SBA-15, MCM-41, MCM-48, KIT-6, FDU-5, and TUD-1, the highest biodiesel yield of 98 % was given by SBA-16 (BLA), attributed to its spherical morphology and strong interaction with WO3–ZrO2 as inferred from SEM and XPS characterizations respectively. From the effect of process parameters on the WO3(10 %)–ZrO2(10 %)/SBA-16 (BLA) catalyst, maximum biodiesel yield was obtained at the temperature of 65 °C, catalyst amount of 200 mg, methanol:oil weight ratio of 10:1 and reaction time of 3 h. Under these reaction conditions, it retained the same biodiesel yield for six recycles after regeneration every time, confirmed its catalytic stability and recyclability.
Engaging the creative heArts of nurse educators: a novel conceptual model
Authors: Hartigan-Rogers Jackie A. , d’Eon Paula 
Published: July 2023

Abstract

Objectives
Nurse educators are increasingly challenged in preparing future nurses to be creative thinkers. The purpose of this innovative quality improvement initiative is to share nursing students’ interpretations of the value arts-based pedagogy (ABP) brings to their nursing practice.

Methods
Braun and Clarke’s approach to thematic analysis was utilized to identify and report patterns of ideas within learners’ interpretations of engaging in an ABP assignment.

Results
The analysis of students’ interpretations led to the creation of a novel conceptual model to encourage and support nurse educators in the use of innovative ABP approaches.

Conclusions
ABP can be seamlessly integrated within teaching and learning methodologies to cultivate meaningful student learning.

Implications for international audience
The intent of the conceptual model is to encourage and support nurse educators in the use of innovative ABP approaches designed for engaging nursing students in active, creative, and challenging learning environments.
Factors associated with mental health among undergraduate nursing students early in the COVID-19 pandemic: an integrative review
Authors: Sugimoto Keiko , Fukuzawa Rieko K. , Togoobaatar Ganchimeg , Park Chang G. , Vonderheid Susan C. 
Published: July 2023

Abstract

Objectives
We aimed to synthesize research findings identifying factors associated with mental health in undergraduate nursing students early in the COVID-19 pandemic.

Methods
Seven electronic databases were searched using key terms and subject headings. JBI Critical Appraisal Checklists were used to evaluate research report quality.

Results
Among 23 reports (19 quantitative and four qualitative) meeting inclusion criteria, negative emotional responses to COVID-19 (fear of infection, perceived risk, uncertainty about care/future), negative behavioral responses to COVID-19 (eating behaviors, problematic internet use, insomnia), and negative coping strategies were associated with more adverse mental health symptoms. Conversely, social support, professional identity, preventive behaviors, sufficient personal protective equipment (PPE), and positive coping strategies were related to fewer symptoms.

Conclusions
During a pandemic, undergraduate nursing students require educational support to promote their ability to avoid severe mental health disorders. Also, educators should strengthen students’ professional identity, provide infection prevention knowledge and skills, and supply sufficient PPE.
Quantitative probing: Validating causal models with quantitative domain knowledge
Authors: Grünbaum Daniel , Stern Maike L. , Lang Elmar W. 
Published: July 2023

AbstractWe propose quantitative probing as a model-agnostic framework for validating causal models in the presence of quantitative domain knowledge. The method is constructed in analogy to the train/test split in correlation-based machine learning. It is consistent with the logic of scientific discovery and enhances current causal validation strategies. The effectiveness of the method is illustrated using Pearl’s sprinkler example, before a thorough simulation-based investigation is conducted. Limits of the technique are identified by studying exemplary failing scenarios, which are furthermore used to propose a list of topics for future research and improvements of the presented version of quantitative probing. A guide for practitioners is included to facilitate the incorporation of quantitative probing in causal modelling applications. The code for integrating quantitative probing into causal analysis, as well as the code for the presented simulation-based studies of the effectiveness of quantitative probing are provided in two separate open-source Python packages.