bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Incidence and Clinical Characteristics of COVID‐19 in Children With IBD During the Omicron Wave: A Single‐Center Experience in China
Authors: Li Rui , Chen Pei-Yu , Li Hui-Wen , Ren Lu , Cheng Yang , Liu Li-Ying , Wei Li-Juan , Zeng Zi-Huan , Xu Wan-Fu , Gong Si-Tang , Geng Lan-Lan 
Published: January 2025

Background and Aims: The pandemic of coronavirus disease 2019 (COVID‐19) had a major impact on the health of people worldwide, including the pediatric inflammatory bowel disease (PIBD) patients. As no study has investigated the susceptibility and disease course of COVID‐19 in PIBD patients after the end of zero‐COVID policy in China, we conducted a retrospective cross‐sectional study in our center.Methods: A cross‐sectional survey enrolling PIBD patients has been completed by online survey, phone, and face‐to‐face assessment. The demographic data, epidemiological characteristics, clinical manifestations, treatment, and prognosis of the patients were analyzed.Results: PIBD patients represented 55.45% (56/101) of SARS‐CoV‐2‐positive cases between December 1st 2022 and January 31st 2023; 67.86% were male; the mean age was 11.15 ± 3.92 years old. Among the SARS‐CoV‐2‐positive cases, three patients (5.36%) were asymptomatic, and 53 patients (94.64%) had mild symptoms. The main symptoms were fever (92.86%), cough (69.64%), nasal congestion or running nose (35.71%), and sore throat (33.93%). No severe case or deaths were reported. All patients recovered from COVID‐19 symptoms within 1 week. We found no significant association between the type of inflammatory bowel disease (IBD) (Crohn’s disease, ulcerative colitis, and unclassified) and SARS‐CoV‐2 infection rates, nor did we observe any correlation between different treatments and the risk of infection. Fifty‐one patients were reported to be in close contact with persons confirmed with COVID‐19 infection, and out of them, 36 patients test positive for SARS‐CoV‐2, which is significantly higher than that in patients without exposure to COVID‐19 (70.59% vs. 33.33%, p = 0.002). A total of 10 patients were underweight, of which nine patients tested positive for COVID‐19 (90% vs. 51.65%, p = 0.048). Meanwhile, unvaccinated patients were also found to be more susceptible to SARS‐CoV‐2 than vaccinated patients (70.97% vs. 48.48%, p = 0.049). The multivariable analysis showed that patients with moderate/severe activity of IBD were associated with an increased risk of SARS‐CoV‐2 infection (odds ratio (OR), 1.12; 95% confidence interval (CI), 1.13–8.33, p = 0.028).Conclusions: The incidence of SARS‐CoV‐2 infection in our center of PIBD patients during the Omicron pandemic was 55.45%. No severity or death case was observed. The incidence was higher in underweight and unvaccinated IBD children. Patients with moderate/severe activity of IBD were at a higher risk of SARS‐CoV‐2 infection.
Impact of Age and Body Mass Index on the Outcomes of Laparoscopic Mesh Sacrocolpopexy
Authors: Khalil Nour , El Kassis Nadine , Moubarak Malak , Chaccour Christian , Maalouf Samer , Nemr Elie , El Hajj Houssein , Moukarzel Maroun , Atallah David 
Published: January 2025

Background: Pelvic organ prolapse (POP) is a benign condition that can adversely affect women’s quality of life. Mesh sacrocolpopexy is an effective surgical treatment for POP, but is considered a complex and risky surgery for obese and elderly women. The objective of this study was to assess the impact of age and obesity on the outcomes of minimally invasive sacrocolpopexy.Methods: We performed a retrospective cohort study reviewing all minimally invasive sacrocolpopexy cases performed between 2003 and 2021. Data on operative time, hospital stay, conversion rate, perioperative injuries, early and late postoperative complications were collected. Surgical success was evaluated by gynecological examination at each follow‐up visit.Results: One hundred seventy subjects were included, of whom 44% were older than 65 years and 58% had a body mass index (BMI) above 25 kg/m2. Seventy percent presented stage III uterovaginal prolapse. All patients achieved a good subjective outcome with no reported prolapse with a mean follow‐up of 6 years. The rate of de novo stress urinary incontinence was 3.2%. Vaginal implant exposure was found in 4% of cases. A bivariate analysis studying the impact of older age (≥ 65 vs. < 65 years) and higher BMI (≥ 25 vs. < 25) on surgical and postoperative outcomes did not show any significant differences between the subgroups (p > 0.05).Conclusion: In experienced hands, laparoscopic sacrocolpopexy can be used as a safe and effective procedure for operable patients with POP, even when patients are between 65 and 80 years or have a BMI of 25 kg/m2 and above.
Adrenomedullin 2/Intermedin Exerts Cardioprotective Effects by Regulating Cardiomyocyte Mitochondrial Function
Authors: Zhao Yunlu , Sakurai Takayuki , Kamiyoshi Akiko , Tanaka Megumu , Ichikawa-Shindo Yuka , Kawate Hisaka , Matsuda Yorishige , Zhang Yan , Guo Qianqian , Li Peixuan , Hoshiyama Ken , Hayashi Marina , Li Jiake , Shindo Takayuki 
Published: January 2025

BACKGROUND:
Adrenomedullin 2 (AM2) plays critical roles in regulating blood pressure and fluid balance. However, the specific involvement of AM2 in cardiac hypertrophy has not been comprehensively elucidated, warranting further investigation into its molecular mechanisms and therapeutic implications.

METHODS:
Cardiac hypertrophy was induced in adult mice lacking AM2 (AM2−/−) using transverse aortic constriction surgery. Comprehensive cardiac morphology, function, histology, and transcriptome/metabolome analyses were conducted. Signal transduction underlying AM2 stimulation in the cardiomyocytes was explored.

RESULTS:
The absence of endogenous AM2 led to the development of severe heart failure after transverse aortic constriction surgery, which was characterized by alterations in the mitochondrial morphology and function associated with glycolysis and the tricarboxylic acid cycle in the heart and cardiomyocytes of transverse aortic constriction–operated AM2−/− mice. AM2 stimulation was associated with the receptor-modifying factor RAMP2 (receptor activity-modifying protein 2), which primarily transduces signals through the MAPK (mitogen-activated protein kinase) pathway and affects the expression of genes involved in glycolysis, β-oxidation, and oxidative phosphorylation. The administration of exogenous AM2 alleviated heart failure following transverse aortic constriction.

CONCLUSIONS:
AM2 crucially regulates mitochondrial functions associated with the glycolysis and tricarboxylic acid cycles in the cardiomyocytes, thereby exerting a protective effect on the heart under pressure overload conditions.
Scaling to Perception: Challenges and Opportunities for Large-Scale Immersive Visualization Facilities
Authors: Polys Nicholas F. , Mohammed Ayat , Sandbrook Ben 
Published: January 2025

Abstract
This paper reflects on the challenges and successes of providing cutting-edge immersive visualization facilities for a variety of academic users at Virginia Tech’s Visionarium and Texas Advanced Computing Center (TACC) (see Figure 1). For over 25 years at Virginia Tech, we have provided cyberinfrastructure and support for designers, engineers, and scientists with data and visualization needs. We consider the history and evolution of these services and inventory several aspects of their research and educational impact. While there are many other examples of successful installations, we present evidence demonstrating the cross-cutting value of these institutional cyberinfrastructure resources and prospectives for future research.
Comprehensive care processes for substance use disorders in adult mental health services: A systematic review
Authors: Reilly John , Meurk Carla , Sara Grant E , Heffernan Ed 
Published: January 2025

Background and Objectives: Assessment and care of substance use disorder within mental health services are essential due to the high prevalence and harms associated with comorbidity. Substance use disorder assessment and care are routinely recommended in clinical guidelines; however, processes are not agreed. This systematic review of routine clinical practice in relation to substance use disorders in adult mental health service aims to identify routine assessment and diagnosis processes, the proportion of patients and service episodes in which they occur and their outputs. Methods: We searched MEDLINE, PsycINFO, Embase and relevant Cochrane databases for articles until July 2024 reporting on substance use assessment, diagnosis or treatment in adults receiving routine mental health service and locating additional articles by snowballing. Variables including setting, study method, period, cohort, substances, clinical assessment type, diagnosis and care pathways were compared. Results: In 137 heterogeneous studies reporting routine practice within a wide variety of adult mental health service from 29 nations, 44 (32%) expected or reported on substance use assessment in domains of pattern or impact. However, 23 studies (17%) reported structured approaches to substance use disorder assessment, while 67 (49%) reported a diagnostic structure, including classification system. Diagnostic prevalence varied markedly. Treatment was reported in 16 studies (12%) and no substance use disorder outcomes were reported. Conclusion: This systematic review shows marked variation in routine practice in mental health service across a range of substance use disorder assessment and diagnosis processes. To better identify substance use disorder, enhance its care and reduce associated morbidity, adult mental health service may benefit from standardising expectations and systematically monitoring the performance of substance use assessment and diagnosis.
Intramuscular pH monitoring before and during exercise in individuals with intermittent claudication compared to healthy controls: A feasibility study
Authors: Ablett Andrew D. , Collins Patrick , Ball Derek , Brittenden Julie , Johnstone Alan J. 
Published: January 2025

Objective In this feasibility study, firstly, we aimed to assess whether intramuscular pH (IMpH) could be measured with a glass-tipped electrode. Secondly, we aimed to explore whether we could monitor changes in skeletal muscle pH before and throughout static (isometric) and after dynamic (treadmill) exercise, comparing individuals with intermittent claudication (IC) to a group of healthy controls. Methods Forty participants with IC (mean age ± SD) 68 ± 8) and 40 healthy volunteers (63 ± 10) were recruited. Participants in the IC group had an ankle brachial pressure index of <0.7 (mean: 0.62 ± 0.13). The first 20 participants in each group underwent isometric ankle dorsiflexion for 120 s at 30% of maximum voluntary contraction and the remainder underwent treadmill exercise (3.6 km/h, 5° incline) to maximal walking distance. A sterilised reusable 1.5 mm shatterproof, heat strengthened glass tipped pH probe inserted using a peripheral venous cannula and in combination with a pH meter was used to measure IMpH of the tibialis anterior muscle prior to, during and continuously for 1 h after exercise. Results Resting IMpH was similar between the groups (median 6.8 (interquartile range (IQR) 6.7-6.9)) for IC individuals and 6.7 (6.6 to 6.8) for controls). Following isometric exercise, the magnitude of the decrease in IMpH was greatest in the IC group (median ΔpH max. in patients −0.2 (IQR: −0.2 to −0.1) versus −0.1 (IQR: −0.2 to −0.1) in the control group ( p = 0.002). After treadmill exercise, the magnitude of the decrease in IMpH (ΔpH max) was greatest in individuals with IC (median ΔpH max. in patients −0.3 (IQR: −0.3 to −0.3) versus 0 (IQR: −0.2 to 0) in the control group, p = 0.04. Conclusions IMpH monitoring with a flexible glass probe inserted into the tibialis anterior muscle is viable and changes in IMpH during static and dynamic exercises are detected.
A scoping review on motor imagery-based rehabilitation: Potential working mechanisms and clinical application for cognitive function and depression
Authors: Hu Yule , Li Yan , Leung Angela Yee Man , Li Jiaying , Mei Xiaoxiao , Montayre Jed , Tao Ran , Yorke Janelle 
Published: January 2025

Objective To map evidence on the characteristics, effectiveness, and potential mechanisms of motor imagery interventions targeting cognitive function and depression in adults with neurological disorders and/or mobility impairments. Data Sources Six English databases (The Cochrane Library, PubMed, Embase, Scopus, Web of Sciences, and PsycINFO), two Chinese databases (CNKI and WanFang), and a gray literature database were searched from inception to December 2024. Review Methods This scoping review followed the Joanna Briggs Institute Scoping Review methodology. Interventional studies that evaluated motor imagery for cognitive function and/or depression in adults with neurological disorders and/or mobility impairments were included. Results A total of 24 studies, primarily involving adults with cerebrovascular diseases, multiple sclerosis, and Parkinson's disease, were identified. Motor imagery was typically conducted at home/clinic, occurring 2 to 3 sessions per week for approximately 2 months, with each session lasting 20 to 30 minutes. The 62.5% of studies (n = 10) reported significant improvements in cognitive function, exhibiting moderate-to-large effect sizes (Cohen's d = 0.48–3.41), especially in memory, attention, and executive function, while 53.3% (n = 8) indicated alleviation in depression with moderate-to-large effect sizes (Cohen's d = −0.72– −2.56). Motor imagery interventions could relieve pain perception and promote beneficial neurological changes in brains by facilitating neurotrophic factor expression and activating neural circuits related to motor, emotional, and cognitive functions. Conclusion Motor imagery could feasibly be conducted at home, with promising effects on cognitive function and depression. More high-quality randomized controlled trials and neuroimaging techniques are needed to investigate the effects of motor imagery on neuroplasticity and brain functional reorganization, thereby aiding in the development of mechanism-driven interventions.
Selecting projection views based on error equidistribution for computed tomography
Authors: Zhang Yinghui , Zhao Xing , Chen Ke , Li Hongwei 
Published: January 2025

Background: Nonuniform sampling is a useful technique to optimize the acquisition of projections with a limited budget. Existing methods for selecting important projection views have limitations, such as relying on blueprint images or excessive computing resources. Methods: We aim to develop a simple nonuniform sampling method for selecting informative projection views suitable for practical CT applications. The proposed algorithm is inspired by two key observations: projection errors contain angle-specific information, and adding views around error peaks effectively reduces errors and improves reconstruction. Given a budget and an initial view set, the proposed method involves: estimating projection errors based on current set of projection views, adding more projection views based on error equidistribution to smooth out errors, and final image reconstruction based on the new set of projection views. This process can be recursive, and the initial view can be obtained uniformly or from a prior for greater efficiency. Results: Comparison with popular view selection algorithms using simulated and real data demonstrates consistently superior performance in identifying optimal views and generating high-quality reconstructions. Notably, the new algorithm performs well in both PSNR and SSIM metrics while being computationally efficient, enhancing its practicality for CT optimization. Conclusions: A projection view selection algorithm based on error equidistribution is proposed, offering superior reconstruction quality and efficiency over existing methods. It is ready for real CT applications to optimize dose utilization.
A reflection on how the absence of a psychodynamic perspective may disadvantage gender care and decision-making
Authors: Spencer Jillian , D’Angelo Roberto 
Published: January 2025

Objective To reflect on factors that may have led to the widespread implementation of gender affirming care (GAC) for minors by psychiatric clinical leaders despite the absence of a robust evidence base and the known risks of harm. Conclusions The progressive rejection of psychodynamic thinking by the profession of psychiatry may have contributed to psychiatrists failing to question key aspects of GAC for minors. Further, numerous unconscious factors potentially contribute to the foreclosure of thinking about the risks of gender medicine.
Appropriate Statin Use in Patients With Newly Diagnosed Acute Ischemic Stroke or Myocardial Infarction at a Tertiary County Teaching Hospital
Authors: Woo Soomin , Seifert Charles F. 
Published: January 2025

Background: Statins are the mainstay of therapy in patients suffering an acute ischemic stroke (AIS) or myocardial infarction (MI); however, several studies have shown that prescribing is not optimal. Objective: The main objective of this study was to evaluate the percentage of patients prescribed appropriate statin therapy upon discharge after an AIS or MI. Methods: This is a single-center retrospective cohort study conducted at a tertiary, county, teaching hospital in patients aged 18 to 89 years who were newly diagnosed with AIS or MI, from September 2017 to September 2022. Results: Six hundred thirty-six individuals were hospitalized for AIS or MI according to ICD-10 codes. Of these, 389 patients were excluded, and 247 were included in the analysis. Although 85% of AIS and MI patients were at very high risk of future ASCVD events, over 25% were not discharged on appropriate statin therapy. Patients who had been taking high-intensity statins or were statin-naïve prior to admission (156/194, 80.4%) were significantly more likely to be discharged with appropriate statin therapy compared to those who had been taking low or moderate-intensity statins at home (27/53, 50.9%, p<0.0001, OR = 3.41, 95% CI = 1.71 to 6.79). Conclusion and Relevance: The treatment of patients with statin therapy following an AIS and MI remains suboptimal, despite most of these patients being at very high risk for further ASCVD events. Significantly more patients on high-intensity statins or were statin naïve on admission were discharged on appropriate therapy.
Horse antithymocyte globulin test doses and infusion reactions in adults with aplastic anemia: A multicenter retrospective experience
Authors: Shinn Lauren T , Wagner Charlotte B , Desai Ruchi , Marini Bernard L 
Published: January 2025

Introduction Horse antithymocyte globulin carries a black box warning for life-threatening anaphylactic reactions, and prescribing information recommends test doses to identify patients at highest risk of this adverse effect. The predictive value of such test doses is not well validated, and practicality of use is unclear. Methods This was a planned secondary analysis of a multicenter, retrospective cohort study in adults with severe aplastic anemia being managed with horse antithymocyte globulin as part of their treatment regimen. Qualitative and quantitative descriptions of test doses and infusion reactions are summarized, alongside key institutional administration practices. Results Of 49 patients who received intradermal test doses, two experienced positive reactions and went onto receive their full horse antithymocyte globulin course through prolonged infusion time or desensitization. Infusion reaction rate in patients with negative test doses was 61%, corresponding to a negative predictive value of 39%. Premedication, infusion time, and infusion reaction management were similar across institutions. Conclusion Horse antithymocyte globulin has a high risk of infusion reactions that must be monitored and managed closely. However, test doses do not consistently predict who will experience an infusion reaction, and their practicality may be limited with current administration practices.
Addition of an NK1 receptor antagonist to standard antiemetic prophylaxis in patients with B-cell lymphoma receiving EPOCH
Authors: English Sloane , Lei Matthew , Sorial Mark , Roeland Eric J. , Lou Uvette 
Published: January 2025

Introduction Data on the optimal management of patients with hematologic malignancies and chemotherapy-induced nausea and vomiting (CINV) are lacking, particularly for multiday chemotherapy regimens. We report our institutional experience in patients with B-cell lymphoma receiving multiday dose-adjusted R-EPOCH chemotherapy utilizing two CINV prophylaxis strategies. Methods We performed a retrospective, single-center, cohort study evaluating hospitalized patients with aggressive non-Hodgkin B-cell lymphoma receiving DA-R-EPOCH (April 2016 to October 2022). All patients received prophylactic corticosteroid and 5HT3-receptor antagonist, and were categorized by the addition of an NK1 receptor antagonist (NK1RA) or not. The primary outcome was complete response (CR, no vomiting, and no rescue medication use) over 120 h. Secondary outcomes included as-needed antiemetic use (acute, delayed, and overall phases), CR without escalating prophylactic antiemetics in cycle 2, and complete control. We performed a descriptive analysis and multivariate logistic regression for NK1RA use, adjusting for age and sex. Results Of 128 patients, 56 (43.8%) received an NK1RA as part of their antiemetic regimen, and 72 (56.3%) did not. No patients received prophylactic olanzapine. CR was achieved in 32 (57.1%) of those who received an NK1RA and 30 (41.7%) who did not (OR 0.45; 95% CI, 0.21–0.96; p = 0.039). We observed trends between groups in as-needed antiemetics use (29 [51.8%] vs. 49 [68.1%]; p = 0.061), with most use in the delayed phase (22 [39.3%] vs. 37 [51.4%], p = 0.173). We found no difference in healthcare utilization between the first and second cycle. Conclusion CINV control in patients with non-Hodgkin B-cell lymphoma receiving DA-R-EPOCH in the hospital was suboptimal. These data support the need to optimize prophylactic antiemetic regimens for patients receiving DA-R-EPOCH.