bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher Art Education at Civilisational Crossroads: Creative, Personal, and Social Needs
Authors: Yalanskyi Andrii 
Published: September 2023

The purpose of the article is to consider current issues of national higher art education in the context of meeting creative, personal, and social needs. Research methodology. To achieve the goal, general scientific (analysis and synthesis, generalisation) and special research methods were used. The systematic-analytical method made it possible to determine the features of modern art education, and the axiological method helped to identify the value priorities of art education, taking into account the needs of society and the artist. The method of theoretical generalisation was used to establish the specifics of the functioning of art education in modern conditions. The scientific novelty of the obtained results lies in the theoretical understanding of modern processes in art education, taking into account its personal, creative, and social potential. Conclusions. In general, the organisation of higher education in Ukraine provides a comprehensive approach to the training of an artist. The level of higher art education largely reflects the state of national education in general, the ability of students to act as producers of material and spiritual values, which characterises them as the spiritual potential of Ukraine. In order to address the issue of artistic education's relevance to contemporary civilisational challenges, its structure should be systematically modernised, taking into account the national educational experience gained. Traditional art education should be aimed at educating not only a producer of material values, but also a specialist capable of passing on his experience to a new generation, promoting spiritual values and interest in artistic activity among society by his own example. On the other hand, art education should enable artists to fulfil their creative and professional needs, which, in turn, should coincide with the development goals and needs of society.
Key words: art education, artist, art, professional realisation, creativity, hermeneutics.
Prerequisites and Methodological Principles of Digital Library Creation in the State Scientific and Technical Library of Ukraine
Authors: Moskalenko Oleksandra , Shmahlii Olena 
Published: September 2023

The purpose of the article is to substantiate the relevance, prerequisites and methodological foundations for creating an electronic library of scientific and technical information in the State Scientific and Technical Library of Ukraine (SSTL). The research methodology is based on a combination of general scientific methods of analysis, synthesis and forecasting, as well as on the use of systemic, informational, structural and functional, comparative, and terminological approaches. The scientific novelty of the study lies in the further development of views on the creation and functioning of an electronic scientific and technical library in the context of the implementation of the principles of open science and open access to scientific and informational resources. Conclusions. The development and implementation of the project on the creation of an electronic scientific and technical information library in the SSTL of Ukraine will contribute to solving a number of important issues, in particular: optimization and expansion of remote access of domestic and foreign users to the documents of the library collection, implementation of virtual reconstruction of scattered collections and funds; informational support for scientific, educational, and production projects; providing access to unique materials – rare books, archival documents, including their special types – patent, regulatory and technical, unpublished; preservation of originals that are at risk of disappearance or damage.
Key words: State Scientific and Technical Library (SSTL) of Ukraine, electronic information resources, electronic library, electronic catalogue, full-text databases, scientific and technical information, open access, open science.
Prevalence of Diabetes Mellitus in Myocardial Infarction Patients -An Observational Study
Authors: Nikita Chauhan  , Paras Chauhan  
Published: September 2023

Abstract:
Background: According to studies, having diabetes is a risk factor in and of itself for developing cardiovascular disease. The World Health Organization (WHO) reports that the worldwide burden of death and morbidity attributable to cardiovascular disease is increasing.
Material & Methods: The present observational research was conducted at our tertiary care institution and lasted six months, from June to November 2022. We recruited 100 AMI patients upon receipt of written informed permission.
Results: 60% of research participants had normal blood sugar levels, 25% previously knew they had diabetes mellitus, 11% had the diagnosis identified while they were hospitalized, and 4% experienced stress-related blood sugar elevations.
Conclusion: In addition to being a predictor of prognosis and recurrences, elevated blood sugar was connected to acute cardiovascular problems, especially in those with acute myocardial infarction.
Keywords: Risk factors, prevalence of diabetes mellitus, and acute myocardial infarction.
Silicon and titanium affect the percentage of juice and color attributes in tomato fruits of plants exposed to salt stress
Authors: Carbajal-Vázquez Víctor H. , Trejo-Téllez Libia I. , Alcántar-González Gabriel , Herrera-Corredor José Andrés , Gómez-Merino Fernando C. 
Published: September 2023

Objective: To evaluate the leaf application of silicon (Si) and titanium (Ti) in three doses (0, 75, and 150 mg L-1), independently, on tomato plants cv. Río Supremo, subjected to saline stress (0, 50, and 100 mM NaCl), on the percentage of juice and color attributes of the fruit.
Design/methodology/approach: Two independent essays were carried out under a completely randomized experimental design in a 32 factorial arrangement, where the first study factor was the NaCl concentration in the nutrient solution and the second factor was the leaf application of Si or Ti. The percentage of juice and color attributes in fruits were determined. An analysis of variance and the comparison of means by Tukey (p ≤ 0.05) with the SAS software were performed.
Results: Salinity was found to reduce the percentage of juice, the color index, and the ratio of “a/b” indexes. Regarding the interactive effects, NaCl with both Ti and Si increases the “b” index. Leaf applications of Si increased the “b” index and reduced the percentage of juice, the color index, and the ratio of “a/b” indexes. Also, Ti improved the color index and the “b” index.
Limitations of the study/implications: The results were obtained in the Río Supremo tomato variety under greenhouse conditions. Other varieties should be tested too.
Findings/conclusions: Si and Ti applied to the leaves have positive effects on the color of the fruits of tomato plants under saline stress.
Strategy Based Technology-Based Startups to Drive Digital Business Growth
Authors: Safitri Hanny , Chakim Mochamad Heru Riza , Adiwijaya Alfri 
Published: September 2023

Lean startup methodology-based strategic formulation to promote the expansion of technology-based startup businesses in Indonesia. About 75% of developing startups fail to expand appropriately, which is a relatively high startup failure percentage. Failure of startups is influenced by time and the relevant industry. Due to the wrong approach being chosen from the startup's first year to its fourth, it was unable to expand. The goal of this study is to develop new general methods for company growth based on the lean startup approach. The goal of this study is to use the Delphi technique to find startup failure indicators, and then to select the primary failed cause using the Analytical Network Process (ANP). The research's next phase is to develop the plan after the failure factor has been determined. The researcher acquired 8 as a consequence of this study. 55 indicators of startup failure factors and factors. Using the ANP model, 10 priorities were determined. addressed by developing a new approach utilizing agile development and the minimal viable product idea. technique, human resource management, and customer relationship management. eventually acquired a fresh approach that entrepreneurs may utilize to promote growth.
Surface modification of Polyether-ether-ketone for enhanced cell response: a chemical etching approach
Authors: Dua Rupak , Sharufa Onessa , Terry Joi , Dunn William , Khurana Indu , Vadivel Jagasivamani , Zhang Yue , Donahue Henry J. 
Published: September 2023

Polyether-ether-ketone (PEEK) is increasingly becoming popular in medicine because of its excellent mechanical strength, dimensional stability, and chemical resistance properties. However, PEEK being bioinert, has weak bone osseointegration properties, limiting its clinical applications. In this study, a porous PEEK structure was developed using a chemical etching method with 98 wt% sulfuric acids and three post-treatments were performed to improve bone cell adhesion and proliferation. Four groups of PEEK samples were prepared for the study: Control (untreated; Group 1); Etched with sulfuric acid and washed with distilled water (Group 2); Etched with sulfuric acid and washed with acetone and distilled water (Group 3); and Etched with sulfuric acid and washed with 4 wt% sodium hydroxide and distilled water (Group 4). Surface characterization of the different groups was evaluated for surface topology, porosity, roughness, and wettability using various techniques, including scanning electron microscopy, profilometer, and goniometer. Further chemical characterization was done using Energy-dispersive X-ray spectroscopy to analyze the elements on the surface of each group. Bone cell studies were conducted using cell toxicity and alkaline phosphatase activity (ALP) assays. The SEM analysis of the different groups revealed porous structures in the treatment groups, while the control group showed a flat topology. There was no statistically significant difference between the pore size within the treated groups. This was further confirmed by the roughness values measured with the profilometer. We found a statistically significant increase in the roughness from 7.22 × 10−3 μm for the control group to the roughness range of 0.1 µm for the treated groups (Groups 2–4). EDX analysis revealed the presence of a 0.1% weight concentration of sodium on the surface of Group 4, while sulfur weight percentage concentration was 1.1%, 0.1%, and 1.4% in groups 2, 3, and 4, respectively, indicating different surface chemistry on the surface due to different post-treatments. Cell toxicity decreased, and ALP activity increased in groups 3 and 4 over 7 days compared with the control group. It is demonstrated that the surface modification of PEEK using a chemical etching method with post-processing with either acetone or sodium hydroxide provides a nano-porous structure with improved properties, leading to enhanced osteoblastic cell differentiation and osteogenic potential.
Expression of HPV-16 E6 and E7 oncoproteins alters Chlamydia trachomatis developmental cycle and induces increased levels of immune regulatory molecules
Authors: Olivera Carolina , Mosmann Jessica P. , Anna Ailen N. , Bettucci Ferrero Gloria N. , Paira Daniela A. , Ferreyra Fernando N. , Martinez María S. , Motrich Rubén D. , Cuffini Cecilia G. , Saka Héctor Alex , Rivero Virginia E. 
Published: September 2023

IntroductionInfection with Human Papillomavirus (HPV) is a recognized risk factor for Chlamydia trachomatis (CT) infection and vice versa. Coinfection of HPV and CT in women is a very common and usually asymptomatic finding that has been linked to increased risk of cervical cancer. It has been demonstrated that CT facilitates the entry of multiple high risk HPV genotypes, leading to damage of the mucosal barrier and interfering with immune responses and viral clearance, which ultimately favours viral persistence and malignant transformation. Although the facilitating effects elicited by CT infection on viral persistence have been reported, little is known about the consequences of HPV infection on CT development.MethodsHerein, we took advantage of a genetically modified human cervical cell line co-expressing HPV-16 major oncogenic proteins E6 and E7, as an experimental model allowing to investigate the possible effects that HPV infection would have on CT development.Results and discussionOur results show that CT infection of HPV-16 E6E7 expressing cells induced an upregulation of the expression of E6E7 oncoproteins and host cell inhibitory molecules PD-L1, HVEM and CD160. Additionally, smaller chlamydial inclusions and reduced infectious progeny generation was observed in E6E7 cells. Ultrastructural analysis showed that expression of E6 and E7 did not alter total bacterial counts within inclusions but resulted in increased numbers of reticulate bodies (RB) and decreased production of infectious elementary bodies (EB). Our results indicate that during CT and HPV coinfection, E6 and E7 oncoproteins impair RB to EB transition and infectious progeny generation. On the other hand, higher expression of immune inhibitory molecules and HPV-16 E6E7 are cooperatively enhanced in CT-infected cells, which would favour both oncogenesis and immunosuppression. Our findings pose important implications for clinical management of patients with HPV and CT coinfection, suggesting that screening for the mutual infection could represent an opportunity to intervene and prevent severe reproductive health outcomes, such as cervical cancer and infertility.
Late Miocene landform construction in east-southern Tibet: seismic evidence and a synthetic review
Authors: Xiang Bo , Xu Xiao , Yu Jiahao , Guo Xiaoyu , Wu You , Li Chunsen , Wu Jiajie , Tong Xiaofei , Luo Xucong 
Published: September 2023

The north-south striking landform perpendicular to the dominant collision zone between the Indian and Eurasian plates was constructed in east-southern Tibet (EST) during the Late Miocene. The building processes remain ambiguous, partly owing to the lack of recognition of crustal-scale architecture. Here we deployed an east-west-oriented 120 km-long short-period dense array across the northwestern corner of EST. Results from P-wave receiver functions show a mid-crustal ductile detachment atop the crystalline basement of the eastern Lhasa terrane that has displaced the overlying crust including the upper part of the Yardong-Gulu Rift (YGR) eastward for about 100 km and an offset Moho geometry left behind beneath the Nyainqentanghla Range. Combined previous studies on the vertical heterogeneity in crustal strength beneath the YGR, a synthetic view implies a decoupled crustal architecture of EST to respond the dynamic interactions between the eastward extrusion of the Tibetan Plateau and the northward penetration of the Indian plate that constitutes the Eastern Himalayan Syntaxis. The integrated processes eventually brought active landform construction in the plateau’s interior and partly contributing to the contemporaneous intensification of monsoon in SE Asia.
Association of serum 25-hydroxyvitamin D with urinary incontinence in elderly men: evidence based on NHANES 2007-2014
Authors: Liu Li , Xu Mingming , Zhou Hang , Hao Xuexue , Chen Xiangyu , Liu Xiaoqiang 
Published: September 2023

BackgroundThe correlation between serum 25-hydroxyvitamin D (25(OH)D) and different sub-types of urinary incontinence in elderly men continues to be uncertain. Hence, we performed this research to evaluate whether serum 25(OH)D levels are correlated with urinary incontinence among elderly men.MethodsThe present study incorporated the male population aged 50 years and above from four cycles of the NHANES database spanning from 2007 to 2014, for the purpose of analysis. The assessment of urinary incontinence was carried out through a correlation questionnaire, while standardized liquid chromatography-tandem mass spectrometry (LC-MS/MS) was adopted to quantify serum 25(OH)D. A weighted multi-factorial logistic regression analysis was carried out to ascertain and investigate any potential correlation that may exist between serum 25(OH)D and urinary incontinence in senior males.ResultsUltimately, a sum of 4663 elderly men were involved in our analysis. The outcomes of the univariable analysis illustrated that the group with vitamin D deficiency exhibited augmented odds of all three urinary incontinence types in comparison to the vitamin D-sufficient group. After accounting for age, race, and BMI, no appreciable variations in the outcomes were noticed. However, after accounting for all covariates, only SUI (OR = 1.677; 95% confidence interval (CI) = 1.074–2.618) and MUI (OR = 1.815; 95% confidence interval (CI) = 1.010–3.260) demonstrated statistical significance.ConclusionDecreased serum 25(OH)D levels were connected with stress urinary incontinence and mixed urinary incontinence in elderly men.
The causal association between polycystic ovary syndrome and susceptibility and severity of COVID-19: a bidirectional Mendelian randomization study using genetic data
Authors: Si Yu , Fei Yuye , Ma Hua , Xu Yating , Ning Li , Li Xiu , Ren Qingling 
Published: September 2023

IntroductionObservational studies have reported an association between polycystic ovary syndrome (PCOS) and COVID-19, but a definitive causal relationship has not been established. This study aimed to assess this association using two-way two-sample Mendelian randomization (MR).MethodsA summary of PCOS characteristics was compiled using the PCOS summary statistics from the Apollo University of Cambridge Repository. COVID-19 susceptibility and severity statistics, including hospitalization and extremely severe disease, were obtained from genome-wide association studies from the COVID-19 Host Genetics Initiative. The primary analysis used the inverse variance-weighted method, supplemented by the weighted median, MR-Egger, and MR-PRESSO methods.ResultsThe forward MR analysis showed no significant impact of PCOS on COVID-19 susceptibility, hospitalization, or severity (OR = 0.983, 1.011, 1.014; 95% CI = 0.958–1.008, 0.958–1.068, 0.934–1.101; and p = 0.173, 0.68, 0.733; respectively). Similarly, reverse MR analysis found no evidence supporting COVID-19 phenotypes as risk or protective factors for PCOS (OR = 1.041, 0.995, 0.944; 95% CI = 0.657–1.649, 0.85–1.164, 0.843–1.058; and p = 0.864, 0.945, 0.323; respectively). Consequently, no significant association between any COVID-19 phenotype and PCOS was established.ConclusionThis MR study suggested that PCOS is not a causal risk factor for the susceptibility and severity of COVID-19. The associations identified in previous observational studies might be attributable to the presence of comorbidities in the patients.
Analysis of sensitive factors for sidetrack drilling in water-flooded oil reservoirs: data mining based on actual field data
Authors: Wang Xiang , Rui Cheng , Liu Haicheng 
Published: September 2023

Sidetracking technology is an important measure to increase production and efficiency, too many complex factors affect the development effect of sidetracking wells. At present, most of the research on sensitive factors of sidetracking wells is based on theory, numerical simulation, or application analysis of limited wells. In this study, we adopt a data-driven research paradigm to conduct data mining studies on the actual data of a large number of sidetracking wells accumulated in the oil fields. Actual data from more than 130 sidetracking wells in oil fields within 5 years is collected and cleaned. An index system including 25 indicators for the analysis of sidetracking effect and a sample set of influencing factors are established. On this basis, scatter plots between various influencing factors and sidetracking development effect parameters are drawn to achieve intuitive qualitative understanding through visualization. The correlation coefficients between each parameter are calculated by Pearson and Spearman correlation analysis methods to quantitatively characterize and analyze the linear and nonlinear correlation degrees between each indicator. A feature importance calculation method based on a decision tree is constructed to calculate and rank the importance of each influencing factor for the development effect of sidetracking wells. The results show that compared with Pearson, the Spearman correlation coefficient can more accurately reflect the complex nonlinear correlation relationship between each indicator. Four indicators such as sidetracking target point position show medium or above correlation with sidetracking development effect. Through the calculation of the feature importance of the decision tree, it can be known that the importance of remaining recoverable reserves to the development effect of sidetracking wells exceeds 10%. The importance of six indicators, such as perforation thickness, is small, all less than 3%. This research work can provide guidance for future sidetracking well design and development work.
Spatial distribution of congenital syphilis in the state of Bahia, Brazil from 2009 to 2018
Authors: Vital Caroline Luz , Reis Renato Barbosa , Soares Jorgana Fernanda de Souza , Miranda Diego Lopes Paim , Reis Mitermayer Galvão 
Published: September 2023

ObjectiveTo describe the temporal trend and spatial distribution of congenital syphilis (CS) cases in the state of Bahia, Brazil between 2009 and 2018.MethodMixed ecological study conducted through the analysis of data obtained from the Notifiable Diseases Information System and the Live Birth Information System. Global Moran Index I was performed in order to analyze spatial autocorrelation of CS cases in the municipalities of Bahia and the Local Spatial Association Indicator (LISA) was used to identify the formation of spatial regimes in the GeoDA software.Results8,786 cases of CS were registered in the period. An increasing growth in CS incidence, with a 511% increase between 2009 and 2018. Spatial autocorrelation was observed between the municipalities (I Moran = 0.452; p &lt; 0.001) and four clusters were identified. More frequently, mothers were aged 20–29 years (50.7%); had incomplete primary education (54.9%); were Black and multiracial (93.2%); received prenatal care (82.2%); 49.0% were diagnosed with syphilis during prenatal care; 68.8% were not adequately treated, and 81.1% of their partners were not treated.ConclusionThe results showed that CS consolidates as a serious public health problem in Bahia, with an incidence 8.4 times higher in the period than the WHO target of 0.5/1,000 live births, predominantly related to inadequate prenatal care and social vulnerability indicators: young mothers with low education levels, as well as individuals identified as Black and multiracial. Thus, programs aimed at women of childbearing age and pregnant women need to be intensified.