bluuebunny/crossref_metadata_2025_split huggingface dataset:
The patent foramen ovale may alter migraine brain activity: A pilot study of electroencephalography spectrum and functional connectivity analysis
Authors: Lei Xiangyu , Wei Meng , Qi Yi , Wang Liang , Liu Chenyu , Guo Yichen , Xu Yue , Cao Xiangqi , Liu Rui , Luo Guogang 
Published: March 2023

BackgroundA link has been shown between patent foramen ovale (PFO) and migraine, particularly migraine with aura. However, it is unknown if PFO might cause migraine by altering cortical excitability and neural network, which may lower the threshold of cortical spreading depression (CSD). This study aims to compare the spectrum power and functional connectivity of the alpha and beta bands of electroencephalography (EEG) across migraine patients with and without PFO.MethodsThirty-five migraine patients with PFO (PFO +), 35 migraine patients without PFO (PFO –) and 20 PFO patients without migraine (control) were enrolled in this cross-sectional analysis. 19-channel EEG was recorded for all patients under resting state and intermittent photic stimulation. Power spectrum density (PSD) and phase lag index (PLI) of alpha and beta bands were then calculated and compared between the three groups.ResultsDuring photic stimulation, the beta band PSD at the occipital area was substantially higher in PFO + migraine patients compared to PFO-migraine patients (p &lt; 0.05, Bonferroni corrected). Subgroup analysis showed that both migraine with and without aura patients with PFO had increased PSD in the alpha and beta bands at the occipital region during photic stimulation (p &lt; 0.05, Bonferroni corrected). Meanwhile, the beta band PLI during photic stimulation was significantly elevated (adjusted p = 0.008, utilizing the network-based statistic technique) in PFO + group compared to PFO-group. Furthermore, although failed to pass the correction, the beta band power in the occipital area during photic stimulation at 20 Hz on O1 (R = 0.392, p = 0.024) and O2 channel (R = 0.348, p = 0.047) was prone to positively correlated with MIDAS score, and during photic stimulation at 12 Hz on O2 channel (R = 0.396, p = 0.022) and 20 Hz (R = 0.365, p = 0.037) on O1 channel was prone to positively correlated to HIT-6 score in PFO+ migraineurs, whereas no similar correlation was found in the PFO-group patients.ConclusionThe outcomes of this investigation suggested that PFO may change the cortical excitability in the occipital lobe of both migraineurs with and without aura. Meanwhile, the beta band PSD on the occipital area during photic stimulation might be an objective measure of severity in migraineurs with PFO.
This meat or that alternative? How masculinity stress influences food choice when goals are conflicted
Authors: Leary R. Bret , MacDonnell Mesler Rhiannon , Montford William J. , Chernishenko Jennifer 
Published: March 2023

IntroductionThis research integrates literature on masculinity stress—the distress experienced as the result of a perceived discrepancy with male gender norms—with research on goal conflict to examine preferences for plant-based meat alternatives (PBMAs). Men experiencing masculinity stress are likely to hold salient a goal of being masculine, which should lead to less preference for PBMAs. However, many of these men simultaneously hold competing goals, such as making ethical food choices, which remain inhibited in favor of the focal masculinity goal. We argue that once men experiencing masculinity stress highlight their masculinity through the selection of a manly product, they satisfy that higher-order goal and are then free to pursue previously inhibited goals, such as making an ethical choice through the selection of PBMAs.MethodsWe present the results of three studies supporting these expectations. Study 1 tests the link between masculinity stress and meat (alternative) consumption using consumer search behavior collected from Google Trends, showing that masculinity stress is positively (negatively) correlated with searches for red meat (PBMAs). Study 2 shows that men experiencing masculinity stress are more inclined to choose PBMAs, provided they are presented within a masculine product context. Study 3 presents a parallel mediation model, showing that ethical considerations (as opposed to masculine goals) shape the choice of PBMA preference.Results and discussionWe conclude with a discussion of theoretical implications for the impression management strategies utilized by men experiencing masculinity stress and practical implications for the growing PBMA industry.
Gastric adenocarcinoma burden, trends and survival in Cali, Colombia: A retrospective cohort study
Authors: Parra-Lara Luis Gabriel , Falla-Martínez Juan Camilo , Isaza-Pierotti Daniel Francisco , Mendoza-Urbano Diana Marcela , Tangua-Arias Andrés R. , Bravo Juan Carlos , Bravo Luis Eduardo , Zambrano Ángela R. 
Published: March 2023

BackgroundGastric adenocarcinoma (GA) has changed in recent decades. Cancer estimates are often calculated from population-based cancer registries, which lack valuable information to guide decision-making (clinical outcomes). We describe the trends in clinical practice for GA using a hospital-based cancer registry over a timespan of 15 years.MethodsA retrospective cohort study was conducted. Data were gathered from adults diagnosed and treated for GA at Fundación Valle del Lili (FVL), between 2000 and 2014, from the hospital’s own cancer registry and crossed with Cali’s Cancer Registry. Additional data were obtained directly from clinical records, pathology reports and the clinical laboratory. Patients younger than 18 years and those for whom limited information was available in the medical history were excluded. A survival analysis was conducted using Kaplan-Meier method.ResultsA total of 500 patients met eligibility criteria. Median age was 64 years (IQR: 54-74 years), 39.8% were female, 22.2% were at an early stage, 32.2% had a locally advanced disease, and 29% a metastatic disease, 69% had intestinal subtype, 48.6% had a positive H. pylori test, 85.2% had a distal lesion, 62% underwent gastrectomy, 60.6% lymphadenectomy, and 40.6% received chemotherapy. Survival at 5 years for all cases was 39.9% (CI 95% 35.3-44.5). Survival decreased over time in all groups and was lower in age-groups &lt;39 and 60-79 with either locally advanced or metastatic disease. Prognostic factors that were significant in the Cox proportional-hazards model were late stages of the tumor (locally advanced: HR=2.52; metastatic: HR=4.17), diffuse subtype (HR=1.40), gastrectomy (subtotal: HR=0.42; total: 0.44) and palliative chemotherapy (HR=0.61).ConclusionsThe treatment of GA has changed in recent decades. GA survival was associated with clinical staging, diffuse subtype, gastrectomy and palliative chemotherapy. These findings must be interpreted in the context of a hospital-based study.
Comparison of doublet and triplet therapies for metastatic hormone-sensitive prostate cancer: A systematic review and network meta-analysis
Authors: Wang Lei , Li Chunxing , Zhao Zichen , Li Xiaojian , Tang Chong , Guan Zhenpeng , Sun Feng , Gu Jin , Li Ningchen 
Published: March 2023

BackgroundThe best choice of first-line treatment for metastatic hormone-sensitive prostate cancer (mHSPC) is unclear. We aimed to compare the effectiveness and safety determined in randomized clinical trials of doublet and triplet treatments for mHSPC.MethodsMedline, Embase, Cochrane Central and ClinicalTrials.gov were searched from inception through July 01, 2022. Eligible studies were phase III randomized clinical trials evaluating androgen deprivation treatment (ADT) alone, doublet therapies [ADT combined with docetaxel (DOC), novel hormonal agents (NHAs), or radiotherapy (RT)], or triplet therapies (NHA+DOC+ADT) as first-line treatments for mHSPC. Outcomes of interest included overall survival (OS), progression-free survival (PFS) and grades 3-5 adverse events (AEs). Subgroup analyses were performed based on tumor burden. The effects of competing treatments were assessed by Bayesian network meta-analysis using R software.ResultsTen trials with 12,298 patients comparing nine treatments were included. Darolutamide (DARO) +DOC+ADT ranked best in terms of OS benefits (OR 0·52 [95% CI 0·39–0·70]), but its advantages were all statistically insignificant compared with other therapy options except for DOC+ADT (OR 0·68 [95% CI 0·53–0·88]) and RT+ADT (OR 0·57 [95% CI 0·40–0·80]). In terms of PFS, enzalutamide(ENZA)+DOC+ADT (OR 0·32 [95% CI 0·24–0·44]) and abiraterone and prednisone (AAP) +DOC+ADT (OR 0·33 [95% CI 0·25–0·45]) ranked best. For patients with high volume disease (HVD), low volume disease (LVD), and visceral metastases, the optimal therapies were AAP+DOC+ADT (OR 0·52 [95% CI 0·33–0·83]), apalutamide+ADT (OR 0·52 [95% CI 0·26–1·05]) and DARO+DOC+ADT (OR 0·42 [95% CI 0·13–1·34]), respectively. For safety, AAP+DOC+ADT (OR 3·56 [95% CI 1·51–8·43]) ranked worst with the highest risk of grade 3−5 AEs.ConclusionsTriple therapies may further improve OS and PFS but may be associated with a decrease in safety. Triplet therapies could be suggested for HVD patients, while doublet combinations should still be preferred for LVD patients.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPEROFILES/303117_STRATEGY_20220202.pdf, identifier CRD4202303117.
The role of magnetic resonance imaging and computed tomography in oral squamous cell carcinoma patients’ preoperative staging
Authors: Thoenissen Philipp , Heselich Anja , Burck Iris , Sader Robert , Vogl Thomas , Ghanaati Shahram 
Published: March 2023

IntroductionThe aim of the study was to evaluate the accuracy of MRI and CT with regard to the detection of lymph node metastases based on the data of specific patients with OSCC who received bilateral neck dissection.Materials and methodsIn a retrospective analysis from 01/2014 to 12/2020 patients who underwent primary tumor resection and bilateral neck dissection were evaluated.Results174 preoperative MRI (78.74%, N=137) and CT (21.26%, N=37) were correlated with the histopathological findings. CT had a sensitivity of 67% and specificity of 68% (p=0.76). MRI showed an overall sensitivity of 66% and a specificity of 68% (p=0.76). In 52.87% of all cases no differences between cN and pN were found. MRI is the method to overestimate lymph node involvement compared to CT (overestimation in 27% vs. 21.62%).ConclusionThe current data indicate that MR and CT show poor efficacy in the detection of cervical metastases. Accordingly, attention must be paid to alternatives to correct local staging modalities. The application of structured bilateral neck dissection needs to be questioned.
Case report: Magnetic resonance imaging-based three-dimensional printing for reconstruction of complex cloacal malformations
Authors: Gang Suiin , Song Sang Hoon , Kwon Jaeyoung , Kwon Hyunhee , Ha Suhyeon , Park Jueun , Kim Namkug , Yoon Hee Mang , Namgoong Jung-Man 
Published: March 2023

BackgroundSurgical reconstruction of the urinary tract, anus, and vagina is the definitive treatment for cloacal malformation. However, this procedure may be technically challenging in patients with a long common channel (&gt;3 cm), because further reconstructive procedures, such as vaginal replacement or vaginal switch maneuver, may be required. Thus, accurate determination of spatial anatomy is essential during surgical planning. Three-dimensional (3D) reconstruction using rotational fluoroscopy, computed tomography (CT), and magnetic resonance imaging (MRI) has recently been reported to help in determining the relationship between the rectum, vagina, and bladder, and provides a more accurate measurement of the channel length compared to conventional cloacography. MRI-based 3D reconstruction provides substantial information regarding soft tissue structures around the cloaca, including the pelvic floor musculature and anus.CaseA 2-year-old girl with cloacal malformation required reconstructive surgery. Colostomy and cystostomy had been performed on the first day of her life. Preoperative loopogram revealed a cloaca with a long common channel (35 mm) and short urethra (9 mm), single vaginal opening in the bladder neck, and the colon anterior to the vagina with a fistula at the vaginal neck. Because the vagina was too short to be pulled through, 3D printing based on MRI was performed to visualize structural relationships prior to surgical correction. Saline was used for cloacal visualization. Furthermore, endoscopy-assisted urogenital mobilization was performed, and vaginal substitution was performed using the rectum. No postoperative complications were observed.ConclusionsWe believe this is the first report of the use of MRI-based 3D imaging and printing, with saline as a contrast agent during surgical planning for correction of cloacal malformation. MRI-based 3D printing is a potentially promising technique for surgical planning of cloacal malformation correction in patients with a long common channel, as it provides detailed information about the surrounding soft tissue structures without exposure to radiation or contrasting agents.
Transcutaneous delivery of sodium bicarbonate increases intramuscular pH
Authors: Gibson Brandon M. , Needham Karen Wiedenfeld , Kaiser Brendan W. , Wilkins Brad W. , Minson Christopher T. , Halliwill John R. 
Published: March 2023

Introduction: Oral bicarbonate loading improves the buffering of metabolic acidosis and may improve exercise performance but can also result in gastric distress. Momentous’ PR Lotion contains a novel composition intended to provide a transdermal delivery vehicle for sodium bicarbonate which could allow the same ergogenic effect without the gastric distress. The present study explored the effect of transdermal delivery of sodium bicarbonate in a resting condition.Methods: We measured the pH from intramuscular dialysate, via microdialysis, of the vastus lateralis during a 2 h application of PR Lotion (40 g of lotion per leg) in 9 subjects (3 women, 6 men). Venous blood samples were obtained for serum pH before and after application. A placebo time control was also performed in 4 subjects (2 women, 2 men). We hypothesized that PR Lotion application would increase pH of intramuscular dialysate.Results: PR Lotion resulted in a rise in pH of 0.13 ± 0.04 units (p &lt; 0.05), which translates to a 28% reduction in [H+]. Increases in serum pH were smaller (∼9%) yet consistent (p &lt; 0.05). In contrast, placebo time control pH tended to decrease (p = 0.08). The effect of PR Lotion on pH tended to correlate with the dose per kg body weight of each individual (r = 0.70, p = 0.08).Conclusion: These observations support the idea of transdermal bicarbonate delivery impacting pH buffering both systemically and intramuscularly. Further work investigating these potential benefits in an exercising model would be critical to establishing PR Lotion’s utility as an ergogenic aid.
The value of a digital management system for the medical records of patients with cerebral hemorrhage
Authors: Zhang Qin , Li Xiao-Dong 
Published: March 2023

ObjectiveThe present study aimed to explore the value of a digital management system based on micro digital imaging technology for the medical records of patients with cerebral hemorrhage.MethodsA total of 540 patients with intracerebral hemorrhage diagnosed and treated in the hospital from November 2016 to November 2019 were selected as the subjects of this study. A digital management system based on micro digital imaging technology was used to establish how to handle the medical records of these patients.ResultsThe medical record management process of patients with cerebral hemorrhage comprises five modules: medical record editing, medical record querying, medical record borrowing management, statistical analysis, and system maintenance. The purpose of these is to manage and store digitalised medical records for patients, present the most useful information on the first page of the medical records, monitor the safety of the medical records, and enable real-time data sharing.ConclusionEstablishing a digital management system based on micro digital imaging technology for the medical records of patients with cerebral hemorrhage can effectively enable the preservation and use of these documents. It improves information management, such as data sharing, security, and the overall level of information. This is worth promoting.
A ReaxFF molecular dynamics and RRKM ab initio based study on degradation of indene
Authors: Hashemi S. Rasoul , Barinovs Girts , Nyman Gunnar 
Published: March 2023

The degradation of indene is investigated using molecular dynamics (MD) with the ReaxFF force field and RRKM theory. Microcanonical rate constants are obtained over a broad energy range (8–25 eV). There is agreement between the results of the molecular dynamics and RRKM calculations at the lower energies, while the molecular dynamics rate constants are larger at the higher energies. At the lower energies there is also agreement with values obtained by using expressions for photodegradation of polyaromatic hydrocarbons from the literature. Values from those expressions however increase even faster with energy than our molecular dynamics rate constants do. At the same time those values are lower than an experimental result at 6.4 eV. This suggests that astrochemical models employing those values may result in unreliable polycyclic aromatic hydrocarbons abundances.
PEMODELAN SISTEM PENDUKUNG KEPUTUSAN PADA BUDIDAYA JAMUR TIRAM
Authors: Nurraharjo Eddy , Sukur Muji , Budiarso Zuly 
Published: March 2023

Sistem kendali telah banyak diterapkan dan dimanfaatkan untuk membantu kinerja manusia seiring dengan perkembangan kebutuhannya. Segenap bidang yang tanpa terkecuali pada bidang kajian utama hal ini adalah bidang pertanian. Sasaran utama dlam kajian ini adalah para petani penggerk dan pembudidaya tanaman produktif jamur.
Banyak pelaku dalam budidaya jamur tiram ini seolah-olah mulai usaha lalu berhenti, dimana beberapa kendala terjadi dan mengakibatkan penurunan aspek kualitas dan kuantitas hasil panen. Salah satu pengaruh utama dan terbesar adalah perubahan dan perbedaan iklim atau cuaca dari suatu musim ke musim berikutnya, dan dari tata letak geografissuatu daerah dengan daerah lainnya.
Sementara itu dari bidang keilmuan spesifik yaitu ilmu komputer telah mengkaji tersendiri sebuah sistem dengan metode sistem pendukung keputusan, dan hal inilah yang akan menjadi bidang implementasi pada sebuah sistem bantu lapisan masyarakat pertanian, dengan melakukan penerapan SPK pada sistem kendali terpadu dan terprogram, terkait dengan permasalahan utama yaitu variabel suhu, kelembaban dan intensitas cahaya.
Realisasi perangkat bantu yang menggunakan algoritma sistem pendukung keputusan terpadu tercipta dengan berhasil membuatnya dalam model alat kontrol menggunakan sensor Light Depending Resistor (LDR) dan sensor suhu beserta kelembaban. Hasil yang diperoleh berdasarkan fungsionalnya adalah nilai rata-rata suhu 25 - 31oCelcius, tingkat intensitas cahyaa pada 200 lumen dan kelembaban berkisar pada 25% - 81% RH. Sistem mampu berjalan dengan sempurna menggunakan kendali mikro Arduino dan telah terimplementasi pada beberapa lokasi mitra petani pembudidaya jamur tiram.
REKAYASA ALAT UKUR PANJANG GELOMBANG SUARA MENGGUNAKAN TABUNG RESONANSIT BERBASIS ARDUINO UNTUK PENGEMBANGAN PRAKTIKUM FISIKA DASAR
Authors: Budiarso Zuly , Nurraharjo Eddy , Listiyono Hersatoto 
Published: March 2023

Abstrak
Perkembangan teknologi digital yang sangat pesat mengubah teknologi sistem kendali dari sistem kendali analog menjadi sistem kendali digital. Salah satu jenis mikrokontroler yang sering digunakan saat ini adalah Arduino. Dengan kemampuan yang ada pada arduino, dapat diterapkan pada alat pengukur panjang gelombang suara. Peralatan yang sering digunakan dalam praktikum fisika dasar tentang gelombang bunyi adalah tabung resonansi. Tujuan dari percobaan tabung resonansi adalah mencari sebuah kondisi dimana terjadi peristiwa resonansi yang ditunjukkan dengan adanya peristiwa interferensi antara gelombang suara yang berasall dari sumber suara di ujung tabung dengan gelombang suara yang dipantulkan oleh permukaan air di dalam tabung. Dengan menggunakan arduino semua peralatan tersebut dapat digantikan. Sumber suara dapat dihasilkan dari arduino yang dapat diatur frekuensinya dengan menggunakan Titik terjadinya peristiwa resonansi digantikan dengan sensor suara, untuk ketinggian permukaan air saat terjadi resonansi digunakan sensor jarak yang hasilnya ditampilkan pada layar lcd, sedangkan untuk mendeteksi ketinggian permukaan air digunakan dua buah sensor cahaya yang diletakkan di tabung bagian bawah dan bagian atas tabung. Untuk mengatur ketinggian permukaan air pada tabung dilakukan dengan menambah dan mengurangi volume air dalam tabung. Dengan menggunakan arduino hasil pengukuran mempunyai tingkat ketelitian lebih tinggi dibandingkan dengan pengukuran secara manual.
Kata Kunci: Arduino, Tabung Resonansi, Sensor, Panjang Gelombang
IMPLEMENTASI METODE SERVQUAL UNTUK PENILAIAN KEPUASAN MAHASISWA TERHADAP PELAYANAN AKADEMIK – STUDI KASUS UNISNU JEPARA
Authors: Minardi Joko , Saputro Heru , Farichah Jihan , Sugiyamta Sugiyamta 
Published: March 2023

Pengolahan data hasil survei kepuasan mahasiswa terhadap layanan akademik yang dilakukan LPM saat ini dirasa masih memiliki banyak keterbatasan dan melewati beberapa proses Panjang, dalam mengumpulkan data survei mahasiswa, masih dilakukan sendiri sendiri dengan menggunakan framework yang berbeda beda. Tujuan penelitian yaitu pembuatan sistem informasi yang mengimplemenatasikan metode servqual untuk penilaian kepuasan­ mahasiswa unisnu terhadap pelayanan akademik. Sumber data dari hasil kuesioner mahasiswa TA.2020 berjumlah 4.433 dan hasil implementasi menggunakan perhitungan slovin 100 sampel data. Metode Service Quality diperoleh rata-rata dari nilai 5 aspek yaitu keandalan, daya tanggap, jaminan, empati, dan nyata, dengan predikat PUAS dan hasil pengujian perangkat lunak (black box testing) dan ISO 9126 sangat layak untuk digunakan. Hasil sistem yang telah dibangun mempercepat admin mengolah data kuisioner penilaian sesuai dengan kriteria dengan banyak kemudahan yang di hasilkan oleh aplikasi ini.
Improving the quality of the activities of cultural institutions through digitalization
Authors: Nesis Yu. L. 
Published: March 2023

Tasks. The author considers the specific aspects of the activities of cultural institutions; identifies current problems in this field; defines the concept of the quality of the activities of cultural institutions and proposes ways to improve it, including through the creation of a unified state information system for the purchase of tickets to cultural institutions of the Russian Federation.Methods. This study uses an integrated approach, general scientific (concretization, abstraction, deduction, induction, analogy) and special methods of cognition (analytical and statistical methods).Results. The author proposes creating a new digital project in the field of purchasing tickets to cultural institutions (museums, theaters, etc.), which would increase the comprehensive quality of their activities. This includes improving the quality of services provided by cultural institutions, improving the planning of tourist and sightseeing routes, managing the flow of visitors in cultural institutions, eliminating the possibility of overflow, preventing the activity of theater and museum ticket speculators, obtaining significant economic effects in the public sector.Conclusions. The unified information system can be used by public authorities in the field of culture and cultural institutions (museums, theaters, etc.), and by the population consuming such services. The system proposed by the author is unique, and its implementation would contribute to improving the quality of services provided by cultural institutions, ensuring transparency of the ticket sale process for all interested parties, reducing the cost of tickets by eliminating intermediary commissions, increasing the revenue of the state budget by eliminating the possibility of ticket fraud, etc.