bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracing the Century‐Long Evolution of Microplastics Deposition in a Cold Seep
Authors: Feng Jing‐Chun , Li Can‐Rong , Tang Li , Wu Xiao‐Nan , Wang Yi , Yang Zhifeng , Yuan Weiyu , Sun Liwei , Hu Weiqiang , Zhang Si 
Published: February 2023

AbstractMicroplastic (MP) pollution is one of the greatest threats to marine ecosystems. Cold seeps are characterized by methane‐rich fluid seepage fueling one of the richest ecosystems on the seafloor, and there are approximately more than 900 cold seeps globally. While the long‐term evolution of MPs in cold seeps remains unclear. Here, how MPs have been deposited in the Haima cold seep since the invention of plastics is demonstrated. It is found that the burial rates of MPs in the non‐seepage areas significantly increased since the massive global use of plastics in the 1930s, nevertheless, the burial rates and abundance of MPs in the methane seepage areas are much lower than the non‐seepage area of the cold seep, suggesting the degradation potential of MPs in cold seeps. More MP‐degrading microorganism populations and functional genes are discovered in methane seepage areas to support this discovery. It is further investigated that the upwelling fluid seepage facilitated the fragmentation and degradation behaviors of MPs. Risk assessment indicated that long‐term transport and transformation of MPs in the deeper sediments can reduce the potential environmental and ecological risks. The findings illuminated the need to determine fundamental strategies for sustainable marine plastic pollution mitigation in the natural deep‐sea environments.
Mobile and Self‐Sustained Data Storage in an Extremophile Genomic DNA
Authors: Sun Fajia , Dong Yiming , Ni Ming , Ping Zhi , Sun Yuhui , Ouyang Qi , Qian Long 
Published: February 2023

AbstractDNA has been pursued as a novel biomaterial for digital data storage. While large‐scale data storage and random access have been achieved in DNA oligonucleotide pools, repeated data accessing requires constant data replenishment, and these implementations are confined in professional facilities. Here, a mobile data storage system in the genome of the extremophile Halomonas bluephagenesis, which enables dual‐mode storage, dynamic data maintenance, rapid readout, and robust recovery. The system relies on two key components: A versatile genetic toolbox for the integration of 10–100 kb scale synthetic DNA into H. bluephagenesis genome and an efficient error correction coding scheme targeting noisy nanopore sequencing reads. The storage and repeated retrieval of 5 KB data under non‐laboratory conditions are demonstrated. The work highlights the potential of DNA data storage in domestic and field scenarios, and expands its application domain from archival data to frequently accessed data.
Chemical Control of CRISPR Gene Editing via Conditional Diacylation Crosslinking of Guide RNAs
Authors: Lei Huajun , Zeng Tianying , Ye Xiaofang , Fan Ruochen , Xiong Wei , Tian Tian , Zhou Xiang 
Published: February 2023

AbstractConditional control of RNA structure and function has emerged as an effective toolkit. Here, a strategy based on a one‐step introduction of diacylation linkers and azide groups on the 2′‐OH of RNA is advance. Selected from eight phosphine reagents, it is found that 2‐(diphenylphosphino)ethylamine has excellent performance in reducing azides via a Staudinger reduction to obtain the original RNA. It is demonstrated that the enzymatic activities of Cas13 and Cas9 can be regulated by chemically modified guide RNAs, and further achieved ligand‐induced gene editing in living cells by a controllable CRISPR/Cas9 system.
Spatiotemporal Acoustic Communication by a Single Sensor via Rotational Doppler Effect
Authors: Zhang Chuanxin , Jiang Xue , He Jiajie , Li Ying , Ta Dean 
Published: February 2023

AbstractA longstanding pursuit in information communication is to increase transmission capacity and accuracy, with multiplexing technology playing as a promising solution. To overcome the challenges of limited spatial information density and systematic complexity in acoustic communication, here real‐time spatiotemporal communication is proposed and experimentally demonstrated by a single sensor based on the rotational Doppler effect. The information carried in multiplexed orbital‐angular‐momentum (OAM) channels is transformed into the physical quantities of the temporal harmonic waveform and simultaneously detected by a single sensor. This single‐sensor configuration is independent of the channel number and encoding scheme. The parallel transmission of complicated images is demonstrated by multiplexing eight OAM channels and achieving an extremely‐low bit error rate (BER) exceeding 0.02%, owing to the intrinsic discrete frequency shift of the rotational Doppler effect. The immunity to inner‐mode crosstalk and robustness to noise of the simple and low‐cost communication paradigm offers promising potential to promote relevant fields.
Extracellularly Detectable Electrochemical Signals of Living Cells Originate from Metabolic Reactions
Authors: Koo Kyeong‐Mo , Kim Chang‐Dae , Kim Huijung , Cho Yeon‐Woo , Suhito Intan Rosalina , Kim Tae‐Hyung 
Published: February 2023

AbstractDirect detection of cellular redox signals has shown immense potential as a novel living cell analysis tool. However, the origin of such signals remains unknown, which hinders the widespread use of electrochemical methods for cellular research. In this study, the authors found that intracellular metabolic pathways that generate adenosine triphosphate (ATP) are the main contributors to extracellularly detectable electrochemical signals. This is achieved through the detection of living cells (4,706 cells/chip, linearity: 0.985) at a linear range of 7,466–48,866. Based on this discovery, the authors demonstrated that the cellular signals detected by differential pulse voltammetry (DPV) can be rapidly amplified with a developed medium containing metabolic activator cocktails (MACs). The DPV approach combined with MAC treatment shows a remarkable performance to detect the effects of the anticancer drug CPI‐613 on cervical cancer both at a low drug concentration (2 µm) and an extremely short treatment time (1 hour). Furthermore, the senescence of mesenchymal stem cells could also be sensitively quantified using the DPV+MAC method even at a low passage number (P6). Collectively, their findings unveiled the origin of redox signals in living cells, which has important implications for the characterization of various cellular functions and behaviors using electrochemical approaches.
Cereal rye cover crop seeding method, seeding rate, and termination timing effects corn development and seedling disease
Authors: Marcos Fernando M. , Acharya Jyotsna , Parvej Md. Rasel , Robertson Alison E. , Licht Mark A. 
Published: February 2023

AbstractCover crops decrease nutrient leaching from high‐input cropping systems and improve soil quality. In Iowa, cereal rye (CR, Secale cereale L.) is the most adopted species due to its winter hardiness, high biomass productivity, and low cost. Field management of CR is still not completely understood, and as its adoption brings more complexity to farmers, especially with the uncertain effects on corn (Zea mays L.) yields, adoption is slow. Additionally, cover crops immobilize N and increase the inoculum of pathogens such as Pythium spp. A 2‐year field experiment was conducted at three locations in Iowa investigating the effect of two seeding methods, three seeding rates, and two termination timings (one location only) of CR on CR biomass and corn growth, root disease, and yield. Cereal rye biomass and consequently corn growth and development were not affected by seeding rate but by seeding method and termination timing. Broadcast CR produced an average of 3.5 times more biomass but 7.2% less corn yield than the drilled CR. Cereal rye when terminated late (3 days before planting [DBP]) produced 2.1 times greater biomass but 4.1% less corn yield compared to early termination (14 DBP). In general, greater root rot incidence and more Pythium clade B were detected in corn seedlings sampled from broadcast CR than drilled CR. Radicle rot incidence of corn was also greater in the late‐terminated plots in 1 year. Farmers should be careful using broadcast seeding and later termination of CR cover crop when planted before corn.
Identification of novel genes for age‐at‐onset of Alzheimer's disease by combining quantitative and survival trait analyses
Authors: Li Yi‐Ju , Nuytemans Karen , La Jong ok , Jiang Rong , Slifer Susan H. , Sun Shuming , Naj Adam , Gao Xiaoyi Raymond , Martin Eden R. 
Published: February 2023

AbstractIntroductionOur understanding of the genetic predisposition for age‐at‐onset (AAO) of Alzheimer's disease (AD) is limited. Here, we sought to identify genes modifying AAO and examined whether any have sex‐specific effects.MethodsGenome‐wide association analysis were performed on imputed genetic data of 9219 AD cases and 10,345 controls from 20 cohorts of the Alzheimer's Disease Genetics Consortium. AAO was modeled from cases directly and as a survival outcome.ResultsWe identified 11 genome‐wide significant loci (P < 5 × 10−8), including six known AD‐risk genes and five novel loci, UMAD1, LUZP2, ARFGEF2, DSCAM, and 4q25, affecting AAO of AD. Additionally, 39 suggestive loci showed strong association. Twelve loci showed sex‐specific effects on AAO including CD300LG and MLX/TUBG2 for females and MIR4445 for males.DiscussionGenes that influence AAO of AD are excellent therapeutic targets for delaying onset of AD. Several loci identified include genes with promising functional implications for AD.
Effect of Induced Transition on the Quantum Entanglement and Coherence in Two‐Coupled Double Quantum Dot System
Authors: Dahbi Zakaria , Anka Maron F. , Mansour Mostafa , Rojas Moisés , Cruz Clebson 
Published: February 2023

AbstractStudying quantum properties in solid‐state systems is a significant avenue for research. In this scenario, double quantum dots appear as a versatile platform for technological breakthroughs in quantum computation and nanotechnology. This work inspects the thermal entanglement and quantum coherence in two‐coupled DODs, where the system is exposed to an external stimulus that induces an electronic transition within each subsystem. The results show that the introduction of external stimulus induces a quantum level crossing that relies upon the Coulomb potential changing the degree of quantum entanglement and coherence of the system. Thus, the quantum properties of the system can be tuned by changing the transition frequency, leading to the enhancement of its quantum properties.
Deuterodehalogenation Under Net Reductive or Redox‐Neutral Conditions Enabled by Paired Electrolysis
Authors: Wood Devin , Lin Song 
Published: February 2023

AbstractInterest in deuterated active pharmaceutical ingredients (APIs) is increasing as deuteration holds promise for kinetic isotope effect (KIE) regulated fine‐tuning of API performance. Moreover, deuterium isotope labeling is frequently carried out to study organic and bioorganic reaction mechanisms and to facilitate complex target synthesis. As such, methods for highly selective deuteration of organic molecules are highly desirable. Herein, we present an electrochemical method for the selective deuterodehalogenation of benzylic halides via a radical‐polar crossover mechanism, using inexpensive deuterium oxide (D2O) as the deuterium source. We demonstrate broad functional group compatibility across a range of aryl and heteroaryl benzylic halides. Furthermore, we uncover a sequential paired electrolysis regime, which permits switching between net reductive and overall redox‐neutral reactions of sulfur‐containing substrates simply by changing the identity of the sacrificial reductant employed.
Regulating the Synergistic Effect in Bimetallic Two‐Dimensional Polymer Oxygen Evolution Reaction Catalysts by Adjusting the Coupling Strength Between Metal Centers
Authors: Fa Dejuan , Yuan Jiangyan , Feng Guangyuan , Lei Shengbin , Hu Wenping 
Published: February 2023

AbstractBimetallic electrocatalysts with its superior performance has a broad application prospect in oxygen evolution reaction (OER), but the fundamental understanding of the mechanism of synergistic effect is still limited since there lacks a practical way to decouple the influence factors on the intrinsic activity of active sites from others. Herein, a series of bimetallic Co−Ni two‐dimensional polymer (2DP) model OER catalysts with well‐defined architecture, monolayer characteristic, were designed and synthesized to explore the influence of the coupling strength between metal centers on OER performance. The coupling strength was regulated by adjusting the spacing between metal centers or the conjugation degree of bridge skeleton. Among the examined 2DPs, CoTAPP‐Ni‐MF‐2DP, which has the strongest coupling strength between metal centers exhibited the best OER performance. These model systems can help to explore the precise structure‐performance relationships, which is important for the rational catalyst design at the atomic/molecular levels.
Ionic Liquid Electrolyte with Weak Solvating Molecule Regulation for Stable Li Deposition in High‐Performance Li−O2 Batteries
Authors: Cai Yichao , Hou Yunpeng , Lu Yong , Zhang Qiu , Yan Zhenhua , Chen Jun 
Published: February 2023

AbstractLi−O2 batteries with bis(trifluoromethanesulfonyl)imide‐based ionic liquid (TFSI‐IL) electrolyte are promising because TFSI‐IL can stabilize O2− to lower charge overpotential. However, slow Li+ transport in TFSI‐IL electrolyte causes inferior Li deposition. Here we optimize weak solvating molecule (anisole) to generate anisole‐doped ionic aggregate in TFSI‐IL electrolyte. Such unique solvation environment can realize not only high Li+ transport parameters but also anion‐derived solid electrolyte interface (SEI). Thus, fast Li+ transport is achieved in electrolyte bulk and SEI simultaneously, leading to robust Li deposition with high rate capability (3 mA cm−2) and long cycle life (2000 h at 0.2 mA cm−2). Moreover, Li−O2 batteries show good cycling stability (a small overpotential increase of 0.16 V after 120 cycles) and high rate capability (1 A g−1). This work provides an effective electrolyte design principle to realize stable Li deposition and high‐performance Li−O2 batteries.
Evaluation of photodynamic therapy effects of novel zinc (II) phthalocyanine through a possible interaction with toll‐like receptor signaling pathway
Authors: Barut Burak , Yalçın Can Özgür , Altun Yasemin , Akkaya Didem , Barut Elif Nur , Baş Hüseyin , Biyiklioglu Zekeriya 
Published: February 2023

In this work, 3‐({6‐[3‐(dimethylamino)phenoxy]hexyl}oxy)phthalonitrile (2) and the target zinc (II) phthalocyanine (3) and its ammonium derivative (3a) are synthesized, and the phototoxic effects of 3a were examined using different methods on A549 lung cancer cells. Then, the toll‐like receptor (TLR) signaling pathway was examined to determine the cell death mechanism in the A549 cancer cells. The results showed that 3a did not have noticeable cytotoxic actions on A549 cells at used concentrations. However, the compound markedly reduced the cell viability when irradiated by the red light for 5 and 15 min (LumaCare/LC‐122A/LC2020‐09‐784, Prob: LUM L [700 nm CL] [15 mW cm−2]). Additionally, Annexin V/PI staining suggested that the cells were induced apoptosis in the presence of 3a (1 μM) when irradiated with red light for 15 min. Furthermore, the expression of TLR2, TLR4, and caspase‐3 significantly increased and phospho‐nuclear factor kappa B/total nuclear factor kappa B decreased compared with that of control group (p < 0.05). These results provide strong evidence that 3a is able to induce A549 cell death in a dose and a red‐light irradiation time‐dependent manner via apoptosis. Therefore, 3a might be an effective photodynamic therapy candidate for lung cancer treatment.
Synthesis of high hydroxyl value polyol from rubber seed oil by using Na2WO4/H3PO4/H2O2‐based catalyst complex formed in aqueous phase
Authors: Thuy Nguyen Thi , Lan Pham Ngoc 
Published: February 2023

AbstractVery high acid value rubber seed oil (RSO) and low acid value esterified rubber seed oil (RSOE) were used to synthesize high hydroxyl polyols in a one‐pot two‐temperature stage reaction. The Fourier transform infrared spectra and proton nuclear magnetic resonance spectra demonstrated the presence of hydroxyl groups in the polyols. By optimizing the influence of H2O2 content and technological conditions such as hydroxylation temperature, pre‐reaction time, and hydroxylation time, a suitable technological process for polyolization was found for each oil. With the same pre‐reaction time (20 min) and hydroxylation time (2 h), 100°C was the suitable temperature for RSOE polyolization and 110°C for RSO. Due to the very high acid value of RSO, the appropriate H2O2 content for its polyolization (DB (double bond)/H2O2 ratio of 1/1.75) needed to be larger than that for RSOE polyolization (DB/H2O2 ratio of 1/1.5). The catalytic selectivity in RSOE polyolization was very high (0.91), so the hydroxyl value of the RSOE polyol reached 500 mgKOH/g while it was only 393 mgKOH/g with RSO polyol.
A review focused on the superhydrophobic fabrics with functional properties
Authors: Antinate Shilpa Sagayanathan , Kavitha Sri Annadurai , Jeen Robert Robert Bellabai , Subbulakshmi Muthuswamy Shanmugasundaram , Hikku Gnanadhas Sobhin Osannal 
Published: February 2023

AbstractSuperhydrophobic (SH) property is a naturally occurring phenomenon that has a wide range of potential applications such as antiicing, anticorrosion, electrowetting, blood typing, and so forth, and therefore, inspires the researchers to mimic them over artificial surfaces to achieve desired properties. Low surface energy and suitable surface roughness are the two key factors that play a vital role in developing SH surfaces. Hence, when the target substrate is introduced with suitable roughness and consequently functionalized with low surface energy, SH can be incorporated. Owing to the SH's wide range of inherent properties such as stain‐resistant, self‐cleaning, flame retardant, oil/water separation, and so forth as well as tunable functionalities such as electrical conductivity, photocatalytic activity, UV‐protection, and so forth, the development of SH fabrics has gained a lot of research attention in recent years. In this context, the present review focuses on the different applications of SH fabrics and their recent research progress.
Two‐step novel aromatic polyimide synthesis and characterization: Survey of energy calculations and diode applications
Authors: Ata Ahmet Çağrı , Yildiko Ümit , Tanriverdi Aslihan Aycan , Ebiri Rüstem , Yiğit Evin , Orak İkram , Cakmak İsmail 
Published: February 2023

AbstractHerein, aromatic polyimides (API) synthesis was carried out by polycondensation of the original diamine (new synthesis) and commercial dianhydride. The original diamine and API were characterized by different analysis techniques. In addition, experimental and quantum chemical calculations of the synthesized API were analyzed by density functional theory method. Quantum theory analysis of atoms in molecules was performed for a structural unit of the compound. Here, the proton transfer phenomenon was investigated. The main purpose of synthesizing API1 was diode application. Therefore, the Au/API‐p‐Si/Al diode was produced accomplishedly. When the electrical characterization of the obtained diode structure was made, electrical parameter values such as ideality factor (n) (between 1.9 and 3.8), barrier height (ΦB) (0.73–0.28 eV), and series resistance (Rs) (1270–40,187 kΩ) were calculated.
Development of soft polymer blend for copper ion detection by electrochemical route
Authors: Mane Savita S. , Joshi Girish M. , Shirsat Mahendra D. , Kaleemulla Shaikh 
Published: February 2023

AbstractIn the present work, we have prepared polymer blend of polyvinyl butyral (PVB) and poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) by solution casting route. Blends were tested for various structural, morphological, and electrochemical techniques. Structural properties were investigated by XRD technique exploring the contribution conducting polymer in host system PVB exhibit amorphous nature. COO functional group contributed in blend configuration was confirmed by FTIR technique. Clustering of PEDOT:PSS in blend system were observed by scanning electron microscopy. Subatomic surface topology and increased roughness due to blending concentration of conducting polymer were analyzed by probe microscopy techniques. Increased softness of blends was confirmed by shore “A” durometer test. PVB/PEDOT:PSS blend was drop casted on glassy carbon electrode and employed for detection of various metal ions. It was deployed for electrochemical sensing of Cu2+ion. Electrochemical sensing investigation was done by differential pulse voltammetry technique. Performance of blends at 4.5 pH, 200 s deposition time and −1.2 V deposition potential was more accurate and sensitive toward detection of Cu2+ion. The developed electrochemical sensor exhibited rapid sensing response in the range of 1.6 to 8.3 μm.Furthermor,e an influence of many analytical parameters such as pH, deposition time and deposition potential on Cu2+ion investigation were disclosed. This investigation may be feasible to construct a very simple, fast, and efficient electrochemical sensing system for toxic heavy metals at low‐level concentration.
Recent advances in hydrogel coatings for urinary catheters
Authors: Dai Simin , Gao Yang , Duan Lijie 
Published: February 2023

AbstractCatheters are commonly used in hospital treatment, but most of the medical materials used in the production of catheters are hydrophobic, with high surface friction and weak antibacterial properties, so a large amount of money is spent on the treatment of catheter‐related urinary tract infections worldwide every year. To improve the comfort of patients, weaken the friction and damage between urinary catheters and urethra, and reduce economic burden, coating the urethral catheter surface is a good strategy. Because of the softness, lubricity and functional network structure (load or graft different substances) of hydrogel, it has a wide range of applications for medical devices. In recent years, the studies of hydrogel coatings in urethral catheters have received more and more attention. This review mainly summarized the research progress of hydrogel coating in recent years, including its function and the method of guiding the grafting of hydrogel to the substrate, and the prospects in the future.