bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards hippocampal navigation for brain–computer interfaces
Authors: Saal Jeremy , Ottenhoff Maarten Christiaan , Kubben Pieter L. , Colon Albert J. , Goulis Sophocles , van Dijk Johannes P. , Krusienski Dean J. , Herff Christian 
Published: August 2023

AbstractAutomatic wheelchairs directly controlled by brain activity could provide autonomy to severely paralyzed individuals. Current approaches mostly rely on non-invasive measures of brain activity and translate individual commands into wheelchair movements. For example, an imagined movement of the right hand would steer the wheelchair to the right. No research has investigated decoding higher-order cognitive processes to accomplish wheelchair control. We envision an invasive neural prosthetic that could provide input for wheelchair control by decoding navigational intent from hippocampal signals. Navigation has been extensively investigated in hippocampal recordings, but not for the development of neural prostheses. Here we show that it is possible to train a decoder to classify virtual-movement speeds from hippocampal signals recorded during a virtual-navigation task. These results represent the first step toward exploring the feasibility of an invasive hippocampal BCI for wheelchair control.
Rise in intraocular pressure with elevator travel in post-vitrectomy patients
Authors: Wong Posey P. Y. , Tsim Nicole C. , Chan Karen K. W. , Lau Ivan H. W. , Mak Andrew C. Y. , Chen Guy L. J. , Iu Lawrence P. L. , Ho Mary , Young Alvin L. , Brelén Mårten 
Published: August 2023

AbstractTo evaluate the impact of elevator travel on intraocular pressure after vitreoretinal surgery with gas tamponade. Patients undergoing pars plana vitreoretinal surgery with and without gas insertion were recruited on post-operative day 1. All intraocular pressures were measured three times by Tono-Pen AVIA (Reichert, USA) on the fourth floor and, after rapid ascent in an elevator, on the 12th floor of the hospital. All patients were observed and asked for any symptoms of pain or nausea for at least 15 min. In this study, 54 patients were recruited. Twenty-seven patients underwent vitreoretinal procedures with gas insertion, while 27 patients without gas insertion acted as controls. The mean age of patients was 60.9 years. The mean changes in intraocular pressure of the patients with gas insertion (+ 1.39 mmHg) were greater than those without gas insertion (− 0.43 mmHg) and statistically significantly different (95% CI 1.17–2.48, P < 0.0001). Patients undergoing vitreoretinal surgery with gas insertion had statistically significant intraocular pressure rise even with 8-floor ascent in the immediate post-operative period. Further studies are needed to evaluate the change in intraocular pressure with a larger range of altitudes and different gases.
Bidirectional associations between periodontal disease and systemic diseases: a nationwide population-based study in Korea
Authors: Nabila Salma , Choi Jaesung , Kim Ji-Eun , Hahn Seokyung , Hwang In-Kyung , Kim Tae-Il , Park Hee-Kyung , Choi Ji-Yeob 
Published: August 2023

AbstractTo evaluate the associations of periodontal disease (PD) with systemic diseases, including diabetes mellitus (DM) and cardiovascular disease (CVD), as well as the reciprocal association. The CVD included the cases of coronary heart disease and heart failure. A prospective study was conducted from 2007 to 2019 using linked data from three databases in Korea. Three separate study groups were formed to individually determine the risks of PD (n = 10,533), DM (n = 14,523) and CVD (n = 14,315). All diseases were confirmed based on physicians’ diagnoses using medical records and self-reports. Cox proportional hazard regression was applied with 95% confidence intervals (CIs) to obtain hazard ratios (HRs). PD was significantly associated with an elevated risk of DM (HR [95% CI]: 1.22 [1.07–1.39]) after full adjustment for age, sex, lifestyle factors, body mass index, dental behaviour and CVD. PD was also found to increase the risk of CVD (1.27 [1.03–1.57]), whereas CVD increased the risk of PD (1.20 [1.09–1.32]) after full adjustment for other covariates including DM. This study found a bidirectional association between PD and CVD, as well as a positive association of PD with DM.
Antioxidant and antimicrobial effects of essential oils from two salvia species with in vitro and in silico analysis targeting 1AJ6 and 1R4U proteins
Authors: Maache Souad , Zbadi Latifa , Ghouizi Asmae El , Soulo Najoua , Saghrouchni Hamza , Siddique Farhan , Sitotaw Baye , Salamatullah Ahmad Mohammad , Nafidi Hiba-Allah , Bourhia Mohammed , Lyoussi Badiaa , Elarabi Ilham 
Published: August 2023

AbstractThe Middle Atlas is a Moroccan territory that serves as an abode to plants with incredible biodiversity, of which aromatic and medicinal plants that have been of folkloric use are a significant component. However, their effective utilization in modern medicine requires the characterization of their phytochemicals to facilitate their entry into drug discovery pipelines. Hence, this study aimed to characterize and investigate the antioxidant activity and antimicrobial effects of the essential oils (EOs) of Salvia lavandulifolia subsp. mesatlantica and Salvia officinalis L. by use of in vitro and in silico assays. Ten phytochemicals were identified in the EOs of S. lavandulifolia, while twenty phytochemicals were identified in S. officinalis. Camphor was the most abundant compound in both species, comprising 26.70% and 39.24% of the EOs of S. lavandulifolia and S. officinalis, respectively. The EOs of both plants exhibited significant DPPH free radical scavenging activity, with S. lavandulifolia and S. officinalis showing estimated scavenging rates of 92.97% and 75.20%, respectively. In terms of Ferric Reducing Antioxidant Power (FRAP), S. officinalis demonstrated a higher value (72.08%) compared to that of S. lavandulifolia (64.61%). Evaluation of the antimicrobial effects of the EOs of S. officinalis and S. lavandulifolia against microorganisms revealed bactericidal activities against Proteus mirabilis and Bacillus subtilis at low concentrations. It showed bactericidal activities against Staphylococcus aureus and Candida albicans at a relatively higher concentration. Molecular docking of antioxidant and antimicrobial proteins offers significant insights into ligand–protein interactions, facilitating the development of innovative therapeutics from the current study. Ultimately, this study identified the phytochemical composition of S. lavandulifolia and S. officinalis and highlighted their potential for therapeutic discovery.
Physical properties, engine performance, and exhaust emissions of waste fish oil biodiesel/bioethanol/diesel fuel blends
Authors: Tarangan Davood , Sobati Mohammad Amin , Shahnazari Shahin , Ghobadian Barat 
Published: August 2023

AbstractIn the current study, the physicochemical, engine performance, and exhaust emission of different ternary fuel blends containing waste fish oil (WFO) biodiesel, bioethanol, and petro-diesel have been investigated. WFO Biodiesel was prepared from waste fish oil via transesterification method. Different physiochemical properties including the kinematic viscosity, density, flash point, pour point, cloud point, and heat value have been measured for different fuel blends and compared with the neat petro-diesel. The performance and exhaust emission of engine have been also studied using different fuel blends using a single-cylinder diesel engine in full load condition at 1800 rpm. It was found that the engine torque, engine power, and thermal efficiency of the ternary fuel blends was reduced by 2.45%, 9.25%, 2.35% averagely in comparison with the neat petro-diesel, respectively. The average break specific fuel consumption was also increased by 10.44% compared to the neat petro-diesel. The emission of carbon monoxide (CO), carbon dioxide (CO2), unburned hydrocarbons (UHC), and nitrogen oxides (NOx) was also measured. It was also found that the utilization of ternary fuel blends results in a considerable reduction in CO and UHC emission by 50.55% and 43.87% on average compared to the neat petro-diesel, respectively. The emission of NOx was also increased by 28.25% on average compared to the neat petro-diesel. It was also found that the NOx emission can be adjusted by tuning the WFO biodiesel and bioethanol contents of the ternary fuel blends.
A hybrid quantum-classical method for electron-phonon systems
Authors: Denner M. Michael , Miessen Alexander , Yan Haoran , Tavernelli Ivano , Neupert Titus , Demler Eugene , Wang Yao 
Published: August 2023

AbstractInteractions between electrons and phonons play a crucial role in quantum materials. Yet, there is no universal method that would simultaneously accurately account for strong electron-phonon interactions and electronic correlations. By combining methods of the variational quantum eigensolver and the variational non-Gaussian solver, we develop a hybrid quantum-classical algorithm suitable for this type of correlated systems. This hybrid method tackles systems with arbitrarily strong electron-phonon coupling without increasing the number of required qubits and quantum gates, as compared to purely electronic models. We benchmark our method by applying it to the paradigmatic Hubbard-Holstein model at half filling, and show that it correctly captures the competition between charge density wave and antiferromagnetic phases, quantitatively consistent with exact diagonalization.
Understanding of the properties of neural network approaches for transient light curve approximations
Authors: Demianenko Mariia , Malanchev Konstantin , Samorodova Ekaterina , Sysak Mikhail , Shiriaev Aleksandr , Derkach Denis , Hushchyn Mikhail 
Published: August 2023

Context.Modern-day time-domain photometric surveys collect a lot of observations of various astronomical objects and the coming era of large-scale surveys will provide even more information on their properties. Spectroscopic follow-ups are especially crucial for transients such as supernovae and most of these objects have not been subject to such studies.Aims.Flux time series are actively used as an affordable alternative for photometric classification and characterization, for instance, peak identifications and luminosity decline estimations. However, the collected time series are multidimensional and irregularly sampled, while also containing outliers and without any well-defined systematic uncertainties. This paper presents a search for the best-performing methods to approximate the observed light curves over time and wavelength for the purpose of generating time series with regular time steps in each passband.Methods.We examined several light curve approximation methods based on neural networks such as multilayer perceptrons, Bayesian neural networks, and normalizing flows to approximate observations of a single light curve. Test datasets include simulated PLAsTiCC and real Zwicky Transient Facility Bright Transient Survey light curves of transients.Results.The tests demonstrate that even just a few observations are enough to fit the networks and improve the quality of approximation, compared to state-of-the-art models. The methods described in this work have a low computational complexity and are significantly faster than Gaussian processes. Additionally, we analyzed the performance of the approximation techniques from the perspective of further peak identification and transients classification. The study results have been released in an open and user-friendly Fulu Python library available on GitHub for the scientific community.
Clinical Evaluation of the Oxysat 2 Monitoring System
Authors: Baris Ronald R. , Wilt Suzanne Lorenzo , Schiavo Joseph , Klobus John J. , Mcafee Thomas 
Published: August 2023

A clinical study was undertaken to determine the accuracy of the Oxysat 2 Monitoring System. A series of 17 patients undergoing cardiopulmonary bypass were studied to compare venous saturation and hematocrit results with standard laboratory values. Samples were analyzed using the Auto Crit Centrifuge and the Corning 2500 Co-Oximeter. Upon analysis of the data, graphs plotting correlation of hematocrit values demonstrated an r2 value of 0.67595 between Oxysat 2 and the Corning 2500. Graphs plotting correlation of percent hematocrit using the Auto Centrifuge and Corning 2500 show an r2 value of 0.94119. Further analysis of graphs plotting correlation of venous saturation using the Oxysat 2 and the Corning 2500 indicated an r2 value of 0.86597.
This study indicated a statistically good correlation of saturation values using the Oxysat 2, while only a statistically moderate correlation was achieved using hematocrit results.
Crystalloid Cardioplegia Versus Oxygenated Crystalloid Cardioplegia in the Isolated Rat Heart
Authors: Whittaker Steven , Puri Sushma , Watson David A. 
Published: August 2023

To determine if the protection afforded by a crystalloid cardioplegic solution could be enhanced by the addition of oxygen, 12 rat hearts were studied using an isolated perfused heart model, with a 2-hour ischemic arrest at 20°C.
Group 1 hearts (n = 6) received a crystalloid cardioplegic solution every 30 minutes of the arrest. Group 2 (n = 6) was treated identically except that the cardioplegic solution was oxygenated. Pre-arrest (control) and post-arrest coronary effluent enzyme levels, heart rate and coronary vascular resistance were determined. In addition time to spontaneous defibrillation was measured.
Control coronary effluent lactate dehydrogenase was elevated in group 2 (p<0.05). There was no significant difference in the other control parameters.
Post-arrest coronary effluent creatine kinase in group 1 and group 2 hearts was 640.67 ± 263.23 and 62.9 ± 43.83 (± SEM) (p<0.05 t-test). The post-arrest heart rate was 200.6 ± 13.8 and 245.5 ± 13.5 (p<0.05). One heart failed to spontaneously defibrillate and one had an irregular rhythm, both were in group 1. Time to spontaneous defibrillation was 58.4 ± 5.71 for group 1 and 44.67 ± 2.7 for group 2 (p<0.05). Post-arrest coronary effluent lactate dehydrogenase was 442.32 ± 180.74 and 100.07 ± 32.08 and showed no significant difference (p = 0.06).
This study demonstrates that at 20°C, markers of ischemic injury are significantly improved, leading us to conclude that the addition of oxygen to the cardioplegic solution may enhance its myocardial protective effect.
Demonstration of Heparin Reversal with Protamine Administration Using an Automated Protamine Dose Assay: A Comparison of Two Methods
Authors: Rivard Dennis C. , Thompson Steven J. 
Published: August 2023

Systemic heparinization is required in procedures utilizing extracorporeal circulation. Once the procedure is complete, heparinization must be reversed. The drug used to neutralize heparin is protamine sulfate. The complications associated with protamine administration are well documented. An accurate and safe method of determining optimal dose is a clinically desirable tool.
A comparison study of 317 patients was performed using two different methods of protamine dose determinations. The first method utilized the classic Bull heparin dose-activated clotting time (ACT) curve determined prior to bypass. The second consisted of a protamine titration curve constructed using a Hemochron CA510 tube containing diatomaceous earth and a PDA699 tube containing a known amount of lyopholized protamine. The intercept of the protamine titration curve with the baseline ACT was multiplied by patient fluid volume to determine protamine dose. All ACT determinations utilized an automated technique.
A comparison of the two methods showed that 95% of the sample (p<0.001) returned to an ACT baseline with a decreased protamine administration using the protamine titration assay.
Expanded Use of the VPCML Oxygenator
Authors: Bourland Mary E. , Schneider Joel A. , Solar Clarence C. , Wellons Harry A. , Kauten James R. 
Published: August 2023

The Variable Prime Cobe Membrane Lung (VPCML) is a membrane gas exchange device originally developed for the short term cardiopulmonary support of infants and small adults. A particular advantage is its low static priming volume of 425 cc. To assess the efficacy of the VPCML in heavier patients, we used it for cardiopulmonary bypass in 123 consecutive adult patients weighing 47-120 kg (mean 78 ± 15 kg). Arterial and venous blood gases were obtained simultaneously at maximum hypothermia and during rewarming.
Venous pO2 was used to assess the adequacy of perfusion. Mean venous pO2 during rewarming between the 60–70 kg group (n=22) and the 90–100 kg group (n=17) was 38±8 mmHg and 38±6 mmHg respectively (p = NS). Our results, with a mean flow of 3.79 ± 0.39 LPM, showed excellent gas exchange at maximum hypothermia and during rewarming regardless of weight range.
In summary, our experience with the VPCML oxygenator demonstrates its ability to safely and efficiently oxygenate a wide range of adult patients while keeping priming volume to a minimum.
Low Volume Isolated IN SITU Lung Perfusion: Results of Studies of Metabolic Stability
Authors: Basile-Borgia Annette , Rannels D. Eugene , Williams Dennis R. 
Published: August 2023

Non-ventilatory lung functions involve uptake and release of compounds across the pulmonary vascular bed. Alterations in these functions may be readily assessed in an isolated, ventilated, small mammal lung perfusion preparation. A previously documented preparation is known to maintain metabolic stability of in situx rat lungs for at least 240 minutes. That model, developed by Watkins and Rannels, requires a rotating drum oxygenator which necessitates the use of 100 ml of perfusate buffer. The effects of 100 ml dilution limit the ability to measure uptake and release of metabolites because increased sensitivity of assay procedures or more prolonged experiments are required. A recently developed preparation requires only 25 ml of recirculating perfusate, clearly reducing substrate and metabolite dilution, and enhancing the sensitivity for detection of changes in pulmonary metabolism.
The intent of this study was to test the vascular permeability and metabolic stability of this low volume lung perfusion model. The low volume, in situ lung perfusion model remained stable for as long as 3 hours. Metabolic stability of the model was demonstrated by measurements of water balance, glucose uptake, lactate production, and protein synthesis. The clinical relevance of isolated lung perfusion is discussed with specific reference to metabolic functions of the lung.
Survey of Blood Conservation Techniques During Open Heart Surgery
Authors: Sistino Joseph J. , Feiner Cheryl J. 
Published: August 2023

The shortage of a safe and adequate blood supply for open heart surgery has prompted the development and institution of numerous blood conservation and autotransfusion techniques. A survey was conducted of 60 hospitals in the Northeastern United States to determine the frequency of application as well as the resultant effect on banked blood usage.
A total of 37 surveys were returned for a response rate of 62%. This represents an annual caseload of 23449 open heart procedures which is more than 10% of the total number performed annually in the U.S.
The following techniques were used during adult cases to conserve blood:
No blood in prime 95%
Membrane oxygenator 67%
Chest drainage autotransfusion 40%
Autotransfusion of suction blood 40%
Pre-bypass volume removal 18%
Hemoconcentrator 8%
Post bypass techniques for recovery of residual pump volume were also surveyed. The following techniques were employed:
Centrifugation 54%
Blood bag collection 31%
Discarded 11%
Hemoconcentration 4%
Kendall's Tau-b correlation coefficients showed a significant association between autotransfusion of suctioned blood (p<.05) and decreasing reported blood use, as well as priming volume and blood use (p<.05), although correlations were of small magnitude. When usage was compared across units of packed red cells, for several blood conservation techniques greater usage was reported in the groups that used the smallest amount of blood.
The Use of a Hollow Fiber Membrane Oxygenator for Extended Extra-Corporeal Support
Authors: Pelley William B. , Taylor Donald D. , Butler Charles F. 
Published: August 2023

There is a small percentage of patients, who having undergone cardiac surgery, are unable to be weaned from cardiopulmonary bypass. Some reports in the literature seem to indicate some success with extended extra-corporeal support. In an effort to reduce the amount of supplies needed and the resulting confusion of utilizing a completely different oxygenator, a hollow fiber membrane oxygenator was selected as the oxygenator of choice for an extended extra-corporeal support system.
The hollow fiber membrane oxygenator for extended extra-corporeal support has been utilized on 5 patients in the past 12 months. Two patients were weaned from the system and all patients expired within 30 days. The hollow fiber membrane oxygenator performed adequately with respect to gas exchange and circulatory support. However, as extended extra-corporeal support approached 15 hours, there was evidence of plasma leakage across the membrane fibers. While there appeared to be no decrease in gas exchange, two hollow fiber membrane oxygenators were replaced because of the leakage.
We conclude that the hollow fiber membrane oxygenator for extended extra-corporeal support may not be adequate for support periods above 12 to 15 hours.
Prevalence and Predictors of Nonadherence to Direct Oral Anticoagulant Treatment in Patients with Atrial Fibrillation
Authors: van der Horst Sabine F. B. , de Vries Tim A.C. , Chu Gordon , Bavalia Roisin , Xiong Helen , van de Wiel Kayleigh M. , Mulder Kelly , van Ballegooijen Hanne , de Groot Joris R. , Middeldorp Saskia , Klok Frederikus A. , Hemels Martin E.W. , Huisman Menno V. 
Published: August 2023

Background For most patients with newly diagnosed atrial fibrillation (AF), direct oral anticoagulants (DOACs) are preferred over vitamin K antagonists. However, there is concern that the lack of monitoring may impair therapy adherence and therefore the anticoagulant effect.
Objective To assess 1-year DOAC nonadherence in patients with AF and a treatment indication of at least 1 year in the Dutch health care setting, and to identify predictors of nonadherence.
Methods We performed a near-nationwide historical cohort study in patients with a novel DOAC indication for AF. Data were obtained from a pharmacy database, covering 65% of all outpatient prescriptions dispensed in the Netherlands. The 1-year nonadherence was assessed by the proportion of days covered; the threshold was set at <80%. Robust Poisson regression analyses were performed to identify predictors of nonadherence.
Results A total of 46,211 patients were included and the 1-year nonadherence was 6.5%. We identified male sex (risk ratio [RR] 1.23, 95% confidence interval [CI]: 1.15–1.33), younger age (age ≥60 to <70 years: RR: 1.15, 95% CI: 1.00–1.33, age <60 years: RR: 2.22, 95% CI: 1.92–2.57; reference age ≥85 years), a reduced DOAC dose (RR: 1.10, 95% CI: 1.00–1.22), a twice-daily dosing regimen (RR: 1.21, 95% CI: 1.12–1.30), and treatment with apixaban (RR: 1.16, 95% CI: 1.06–1.26, reference rivaroxaban) or dabigatran (RR: 1.25, 95% CI: 1.14–1.37) as independent predictors of 1-year nonadherence.
Conclusion One-year nonadherence to DOACs was low yet relevant in patients with AF newly prescribed a DOAC. Understanding the predictors for nonadherence may help identify patients at risk.
A Patient with Recurrent Strokes: Approach to Coagulopathy
Authors: Zúñiga Gabriel Alejandro , Kandula Pranav , Sandefur Hardy , Tafur Alfonso J. 
Published: August 2023

AbstractDespite anticoagulation recommendations, patients may present with recurrent events. While medication adherence is always a concern, assessment of anticoagulation failure demands a systematic approach, taking into account the potential limitations of anticoagulants and a review of differential diagnoses for comorbidities. We illustrate our approach in a case presentation.