bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sampling mass mortality events to enable diagnoses: A protocol using freshwater mussels
Authors: Cossey Daniel A. , Dennis Michelle M. , Richard Jordan , Della Torre Camilla , McElwain Andrew , Waller Diane L. , Knowles Susan , Brian Joshua I. , Leis Eric , Burioli Erika A. V. , Aldridge David C. 
Published: January 2025

Abstract

Many taxa around the globe are threatened by often unexplained mass mortality events (MMEs), which can decimate populations and compromise key ecosystem functions. One example of a highly threatened taxon facing frequent MMEs is freshwater mussels (Unionida).

There has been a recent increase in interest in understanding the causes of freshwater mussel MMEs, but standardised methodologies for how best to respond to them to facilitate diagnoses are unavailable. When an MME is observed, swift and appropriate sample collection is imperative owing to the transient nature of these phenomena.

Here we provide structured guidance that will facilitate rapid and appropriate sampling of MMEs, using freshwater mussels as an example. We set out standardised procedures for sample collection, preparation and preservation.

The procedures we outline will improve our capacity for diagnostic investigations of MMEs and other mortality events, not only in freshwater mussels but also across many other taxa. This, in turn, can inform appropriate management responses.
First‐year burden of disease for babies admitted to special care nurseries: Systematic review and meta‐analysis
Authors: Aggarwal Varnika , Cron Hayley T. , Di Sipio Marcus , Liu Sue , McBain Katie , Mckenna Kieran , Cheong Jeanie L. Y. , Wang Jing 
Published: January 2025

AbstractAimThis systematic review aimed to report on health outcomes of newborn babies admitted to special care nurseries up to age 1 year, and where possible, compare their outcomes with those of healthy term babies.MethodsSystematic searches through Ovid MEDLINE, PubMed and Embase databases. We included studies reporting outcomes up to age 1 year for special care nursery babies and moderate‐late preterm babies, restricting to studies published after 2000. We dual‐screened studies and extracted study characteristics, prevalences and risk of health outcomes. We conducted meta‐analysis to combine prevalence and risk estimates of each outcome.ResultsAmong 22 585 eligible studies, 21 relevant studies were identified. Jaundice, hypothermia, hypoglycaemia and respiratory disease were prevalent in special care nursery babies, with pooled prevalence from 19% to 32%. Compared with healthy term babies, the special care nursery group had higher risk of all reported outcomes with pooled risk ratios from 1.93 to 14.85. There were limited studies reporting outcomes after discharge.ConclusionBabies admitted to special care nurseries face a higher burden of disease compared with non‐admitted term babies, but there is currently limited literature describing their post‐discharge outcomes.
On fostering employee participation in voluntary corporate‐sponsored wellness programs
Authors: Sava M. Gabriela , Bichescu Bogdan C. , Scott Kristin , Krivacek Sara 
Published: January 2025

AbstractAs organizations are increasingly turning to voluntary wellness programs to improve employee well‐being, the majority of studies in literature have focused on corporate‐level benefits of wellness programs, such as productivity. However, there is a scarcity of studies that examine the intrinsic motivators that influence employee participation in such programs. In this study, we use a unique secondary dataset from a voluntary corporate wellness program and propose a novel theoretical framework based on motivational and behavioral theories to examine and understand the participants' behavior. Our findings show that frequent participants are overall healthier and have a stronger intrinsic motivation to commit to a wellness program, as they are better in allocating their limited time resources between various wellness activities. In contrast, one‐time participants prove to be less health‐conscious and interested in investing time and energy in a wellness program. This study makes several contributions to theory and practice by identifying the individual characteristics and intrinsic motivational factors that compel participants to engage in frequent participation in wellness programs. We also offer recommendations to program administrators on how to personalize ongoing wellness programs to bolster employees' participation and promote more health‐conscious behaviors.
Current Burden of Lean Metabolic Dysfunction‐Associated Steatotic Liver Disease Among US Adults, 2017–2023
Authors: Kim Donghee , Danpanichkul Pojsakorn , Wijarnpreecha Karn , Cholankeril George , Loomba Rohit , Ahmed Aijaz 
Published: January 2025

ABSTRACTOur study investigated the prevalence of lean steatotic liver disease (SLD) and its subcategories, including metabolic dysfunction‐associated steatotic liver disease (MASLD), metabolic dysfunction‐related and alcohol‐related SLD (MetALD), and alcohol‐related liver disease (ALD) among lean adults in the US. Analysing data from 2965 lean adults (≥ 18 years) from the National Health and Nutrition Examination Survey (2017–2023), we found the age‐adjusted prevalence of lean SLD to be 12.8%. Specifically, the prevalence was 9.3% for lean MASLD, 1.3% for MetALD and 1.0% for ALD. Notably, within the MASLD group, significant fibrosis, advanced fibrosis, and cirrhosis were observed in 5.6%, 2.4% and 2.0%, respectively.
Moderating effect of attachment to parents on the association between bullying and self‐esteem among early adolescents aged 10 to 12
Authors: Miljkovitch Raphaële , de Terrasson Delphine , Awad Sarah , Sirparanta Aino E. , Mallet Pascal 
Published: January 2025

AbstractThe aim of this study was to examine whether attachment to each parent moderates the relationship between bullying victimisation and self‐esteem. The sample consisted of 250 junior high school students (114 males, 136 females; mean age: 11.3 years). The administered scales were the Bully/Victim Questionnaire Revised, the Inventory of Parent and Peer Attachment for Children and the Rosenberg Self‐Esteem Scale. Results showed that early adolescents subjected to bullying had lower self‐esteem than non‐bullied peers. For girls, attachment to mother also accounted for self‐esteem over and above the effect of bullying. For boys, attachment with the father appeared as a pure moderator of the effect of bullying as the association with self‐esteem was non‐significant when attachment scores were high. The findings suggest that attachment to same sex parents may foster better self‐esteem in the face of bullying. Parents' participation in preventive measures could be encouraged.
Leading by example: Experimental evidence that therapist lived experience disclosures can model the path to recovery for clients
Authors: Robertson Alysia M. , Cruwys Tegan , Stevens Mark , Platow Michael J. 
Published: January 2025

AbstractA common guideline for self‐disclosure is that therapists should only share recovered personal experiences with clients (i.e., no longer distressing). However, theoretical rationale and empirical support for this claim is limited. Drawing on identity leadership theorizing, we investigated whether recovery disclosures are beneficial to the extent that they signal a therapist's aspirational prototypicality (i.e., embodiment of an aspirational identity for clients). Across two experimental studies (N = 545), we recruited clients, therapists and general population adults. Participants read a group therapy for depression vignette in which the therapist disclosed: nothing, professional experience with depression, current depression, recovered depression or recovered anxiety. Participants rated the prototypicality of the therapist, the extent to which they perceived the therapist positively, the therapist's expertness and the expected prognosis for therapy. Contrary to our hypotheses, the type of disclosure did not significantly affect positive perceptions, expertness or expected prognosis ratings. However, the therapist disclosing a recovered and relevant condition (recovered depression) was rated as significantly more aspirationally prototypical than the other therapists. Given prior evidence that group therapists are more effective when viewed as aspirationally prototypical, our findings suggest that recovery disclosures may represent one way therapists can signal their prototypicality and enhance their effectiveness.
‘They attacked you just like that’: Negotiating racial epistemics in making claims about racism
Authors: Sambaraju Rahul 
Published: January 2025

AbstractSocial psychological research on race and racism has shown that claims about racism are not always accepted or received as valid reports. In this paper, I offer racial epistemics as one mechanism by which race‐talk takes place. I examine how ascribing category‐bound entitlements to experiential or other knowledge about racism is variously realised and complicated in the production of claims about racism. Through examining news media accounts where Black persons were invited to talk about their experiences of racism in India, I show that despite ascribing a privileged epistemic position to Black persons, recipients (interviewers and other panellists) could make salient epistemic entitlements to commonsense, specialised, or other forms of (racial) knowledge in collaboratively establishing, confirming or correcting, and challenging claims about racism in India. The findings are discussed in relation to the broader understanding of racism in social psychology. The data are in Indian English.
Gemcitabine and docetaxel for high‐risk non‐muscle‐invasive bladder cancer: EuroGemDoce group results
Authors: Scilipoti Pietro , Longoni Mattia , de Angelis Mario , Zaurito Paolo , Massiet Albane , Dutto Daniele , Soria Francesco , Álvarez‐Maestro Mario , Bazán Alfredo Aguilera , Pradere Benjamin , Klatte Tobias , Contieri Roberto , Hurle Rodolfo , Krajewski Wojciech , Subiela José Daniel , Pichler Renate , Szostek Aleksandra , Marcq Gautier , Elena José Luis Rodríguez , Aranda Javier , Gontero Paolo , Rouprêt Morgan , Shariat Shahrokh F. , Necchi Andrea , Montorsi Francesco , Briganti Alberto , Xylinas Evanguelos , Moschini Marco ,   The EuroGemDoce Study Group Collaborators,   European Association of Urology ‐ Young Academic Urologists (EAU‐YAU),   Urothelial Carcinoma Working Group
Published: January 2025

ObjectiveTo evaluate the oncological efficacy and safety of sequential intravesical gemcitabine/docetaxel (Gem/Doce) therapy in a European cohort of patients with high‐risk and very‐high‐risk non‐muscle‐invasive bladder cancer (NMIBC) after previous Bacillus Calmette–Guérin (BCG) treatment.Materials and MethodsData were retrospectively collected from 95 patients with NMIBC, treated with Gem/Doce at 12 European centres between 2021 and 2024. Patients previously treated with BCG who had completed a full induction course and received at least one follow‐up evaluation were included. One‐year disease‐free survival (DFS), high‐grade DFS and progression‐free survival (PFS) were estimated using Kaplan–Meier curves. Adverse events (AEs) were recorded through medical interviews.ResultsOf 75 patients, 63 (84%) were classified as having high‐risk and 12 (16%) as having very‐high‐risk NMIBC. Over a median (interquartile range) follow‐up of 9 (5–14) months, 20 patients (27%) relapsed and five (6.7%) underwent radical cystectomy. The 1‐year DFS was 73% (95% confidence interval [CI] 62–86%), 1‐year high‐grade DFS was 79% (95% CI 68–91%) and 1‐year PFS was 95% (95% CI 90–100%). AEs occurred in 34 patients (45%), with six (8.7%) experiencing severe AEs. Limitations of the study include the short follow‐up and variability in both treatment dwelling times and dosage across centres.ConclusionThe intravesical Gem/Doce regimen demonstrated promising short‐term oncological outcomes and was well tolerated in this cohort of patients with high‐ and very‐high‐risk NMIBC previously treated with BCG. Prospective studies and randomised trials are awaited to define the ideal candidates for Gem/Doce therapy and to standardise treatment protocols.
Identification of clinicopathological‐specific driver gene and genetic subtyping of colorectal cancer
Authors: Li Jianjiong , Wang Chunnian , Yang Changshun , Bao Hua , Li Ningyou , Huang Xianqiang , Gong Wei , Hong Xinyue , Yin Jiani C. , Pang Jiaohui , Gan Meifu , Yuan Danping 
Published: January 2025

AbstractThis study analyzed targeted sequencing data from 6530 tissue samples from patients with metastatic Chinese colorectal cancer (CRC) to identify low mutation frequency and subgroup‐specific driver genes, using three algorithms for overall CRC as well as across different clinicopathological subgroups. We analyzed 425 cancer‐related genes, identifying 101 potential driver genes, including 36 novel to CRC. Notably, some genes demonstrated subgroup specificity; for instance, ERBB4 was found as a male‐specific driver gene and mutations of ERBB4 only influenced the prognosis of male patients with CRC. This sex disparity of ERBB4 was validated in an independent large‐scale Memorial Sloan Kettering Cancer Center CRC cohort with 2444 samples. Furthermore, using network‐based stratification based on protein–protein interaction, we classified the microsatellite stable (MSS) and unstable (MSI) CRCs into six and three major subtypes, respectively, each showing unique phenotypes and prognoses. In MSS CRC, cluster 5 (APCAMER1–KRAS) and cluster 2 (RNF43–BRAF–PIK3CA) were predominant, and cluster 5 showed a superior overall survival compared with cluster 2. This extensive heterogeneity in driver gene mutations underscores the complexity of CRC and suggests significant implications for treatment and prognostic assessments.
Morbid obesity among Crohn's disease patients is on the rise and is associated with a higher rate of surgical complications after ileocolic resection
Authors: Rudnicki Yaron , Calini Giacomo , Abdalla Solafah , Colibaseanu Dorin , Larson David W. , Mathis Kellie L. 
Published: January 2025

AbstractAimCrohn's disease (CD) is regarded as a wasting disease, yet there is a growing population of CD patients with a body mass index (BMI) of 35 and above. The rate of postoperative complications is relatively high in CD patients but might be even higher in CD with morbid obesity (MO).MethodsThis was a retrospective study using a prospectively maintained database of all patients undergoing Ileocolic resection for CD between 2014 and 2021 in two referral centres, comparing postoperative complication rates according to BMI.ResultsThree hundred and forty‐six patients were identified. Sixty patients (17%) had a BMI over 30 kg/m2, and 28 (8.1%) had a BMI of over 35 kg/m2 (>35 group). The BMI >35 group had more women (78.6% vs. 52%, P < 0.1), a higher rate of patients not receiving an anastomosis (7.1% vs. 2.5%, P = 0.02), a higher rate of any postoperative surgical complication (32.1% vs. 25.2%, P = 0.4), with a higher rate of Clavien–Dindo ≥3 (14.3% vs. 7.2%, P = 0.25), a higher rate of stoma creation on reoperation for complications (7.2% vs. 1.7%, P = 0.04), a higher rate of 30‐day readmission due to intra‐abdominal abscess (10.7% vs. 4.7%, P = 0.2), but a lower rate of postoperative medical complications (3.6% vs. 15.7%, P < 0.01).ConclusionsThe rate of MO among CD patients requiring ileocolonic resection is on the rise. MO in this setting is associated with statistically non‐significant increases in all surgical complications, severe complications, readmission, and a higher chance for a bailout stoma creation upon reoperation. However, MO seems to be a protective factor for medical postoperative complications, which might suggest better nutritional status.
Protocol for a 1‐year randomised, controlled, parallel group, open‐label trial on the effects and feasibility of time‐restricted eating in individuals with type 2 diabetes‐ The REStricted Eating Time in the treatment of type 2 diabetes (RESET2) trial
Authors: Termannsen Anne‐Ditte , Varming Annemarie , Bjerre Natasja , Wodschow Helena Z. , Hansen Gitte S. , Jensen Nicole J. , Persson Frederik , Bagger Jonatan I. , Panda Satchidananda , Finlayson Graham , Ewers Bettina , Hansen Dorte L. , Nørgaard Kirsten , Rungby Jørgen , Grunnet Louise G. , Blond Martin B. , Hempler Nana F. , Færch Kristine , Quist Jonas S. 
Published: January 2025

AbstractAimTime‐restricted eating (TRE) limits the time for food intake to typically 6–10 h/day without other dietary restrictions. The aim of the RESET2 (the REStricted Eating Time in the treatment of type 2 diabetes) trial is to investigate the effects on glycaemic control (HbA1c) and the feasibility of a 1‐year TRE intervention in individuals with overweight/obesity and type 2 diabetes. The aim of the present paper is to describe the protocol for the RESET2 trial.MethodsRESET2 is a randomised, controlled, parallel‐group, open‐label trial. One hundred and sixty individuals with type 2 diabetes (HbA1c >53 mmol/mol (>7.0%)), and Body Mass Index ≥25 kg/m2 will be randomised to standard care plus TRE, or to standard care and habitual living. Both the intervention and control group will follow standard diabetes care including regular clinical visits 3–4 times/year. The intervention is divided into two periods: (1) a 3‐month TRE period with a fixed eating window with a self‐selected timing to obtain data from the participants' experiences with TRE and (2) a 9‐month individually adjusted TRE period. Participants in the TRE group will be instructed to reduce their eating window by a minimum of 3 h/day compared to the habitual eating window and with an eating window of 8–10 h/day. Test days will be scheduled at baseline, after 3 months and after 1 year. The primary outcome is HbA1c (evaluated 3 months and 1 year after randomisation) and secondary outcomes are body weight, fat mass, continuous glucose monitoring derived time‐in‐range and use of antidiabetic medicine (evaluated 1 year after randomisation). Additionally, we will conduct a process evaluation to assess whether the TRE intervention functioned as hypothesised.
Evaluating the impact of severe hypoglycaemia definition wording on severe hypoglycaemia history assessment
Authors: Lin Yu Kuei , Ye Wen , Hepworth Emily , Ang Lynn , Amiel Stephanie A. , Fisher Simon J. 
Published: January 2025

AbstractAimSeveral wordings of the definition of severe hypoglycaemia (SH) exist. This study aims to evaluate how different SH definition wordings affect SH history assessment.MethodsIn this cross‐sectional study, surveys were emailed to registrants of the T1D Exchange, a U.S. national type 1 diabetes patient registry. Participants' demographic information was collected. Six‐month SH history was evaluated with questionnaires including SH definition wordings from either (1) professional societies, (2) a diabetes community website, or (3) a hypoglycaemia research questionnaire. Analyses included the McNemar test, pairwise Wilcoxon signed‐rank test, logistic regression analysis, Kappa statistics, and Spearman correlation.ResultsA total of 1580 valid responses were obtained from participants (52% female; mean ± SD age: 46 ± 15 years; 95% White; mean ± SD diabetes duration: 25 ± 16 years). Questionnaires with four different SH definition wordings yielded significant variations in the prevalence of SH (i.e., having developed at least one episode of SH) and the number of SH episodes: the ADA/ENDO 2013 definition wording yielded the highest results on both metrics, whereas HypoA‐Q and ADA 2023 yielded the lowest. Among participants reporting at least one SH episode, the number of episodes identified with the different SH definition wordings was poorly correlated (Rs: 0.09–0.37; p < 0.001). Race, education level, and household income were associated with higher odds of discrepancies in SH history (p < 0.05).ConclusionThis U.S. national survey with individuals living with type 1 diabetes demonstrated significant discrepancies in SH history when assessed with different SH definition wordings. Race and socioeconomic status were associated with these discrepancies.
Influence of Conservative or Invasive Treatments on the Occurrence of Sequelae in Permanent Successors After Injuries in the Support Tissues of Incisors Deciduous Teeth: A Cohort Study
Authors: Fagundes Fabio Anevan Ubiski , da Silva Clemente Gabriella Oliveira , Jural Lucas Alves , da Costa Mariana Pires , Marinho Maria Clara Frias Lobo , Maia Lucianne Cople , Fonseca‐Gonçalves Andréa 
Published: January 2025

ABSTRACTObjectiveTo assess the influence of conservative or invasive treatments on the appearance of sequelae in permanent successor teeth (SPT) after injuries in the support tissues of anterior deciduous teeth (ISTDT).MethodsThis cohort study accompanied 52 children with ISTDT up to the complete eruption of the permanent successor to investigate the presence or not of SPT. Trauma was clinically evaluated according to the International Association for Dental Traumatology. Sex, age at the time of trauma (ATT), type and severity of trauma, sequelae in anterior deciduous teeth (SDT), treatment type (conservative—without exodontia/ invasive—with exodontia), seeking care (immediate/late), and the caregiver's education level (CEL) were collected. Regression models were performed (p = 0.05).ResultsOf the children (ATT = 3.6 ± 1.5 years), boys (52/57.1%) were the majority. The teeth (n = 91) injuries were lateral luxation (26/28.6%), intrusion (22/24.1%), concussion (20/22.0%), subluxation (19/20.9%), and extrusion (4/4.4%), that affected only incisors. Most teeth (63/69.2%) received late care, presented SDT (62/68.1%) and were treated conservatively (73/80.2%). There was no association of sex (p = 0.611), SDT (p = 0.705) and seeking care (p = 0.800) with SPT. The treatment type did not influence the SPT occurrence (p = 0.923), independent of the ATT, trauma severity and the educational level of the caregiver. The lower the ATT (p = 0.026) and the more severe the trauma (p = 0.009), the higher the number of SPT.ConclusionThe treatment type of anterior deciduous teeth, mainly considering incisors, did not influence the appearance of SPT, which leads us to always choose the most conservative treatment, independent of the child's age, the injury severity, and the caregiver's educational level.