bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of glycaemic control on exertion in children with type 1 diabetes mellitus in FOX children's recreational camp settings
Authors: Bolotskaya L. L. , Golubkina Yu. Yu. , Frolova T. M. 
Published: August 2023

ANO “Children’s Camp FOX CAMP (Lager’ Lisonok)” has been operating in Russia since 2019. Changes of observations in the Moscow region, Sochi, Kaliningrad region, Sochi, Gelendzhik, Chelyabinsk region, Altai. In the period from 2019 to 2022, 796 children and adolescents with type 1 diabetes mellitus (DM1) visited the shifts and active tours of the ANO “Children’s Camp FOKS CAMP (Lager’ Lisonok)”. The priority of children’s recreation is a focus on increased activity: marathons at various distances, football matches, basketball, alpine skiing and long hikes in the mountains, rafting. It is known that activity in patients with type 1 diabetes increases sharply by the level of blood increase, by a decrease in this indicator. In order, to prevent the development of hypoglycemia during heavy exercise, it is very important to quickly determine blood glucose using a glucometer and take the necessary measures to stop it. Thus, the presence of sufficient shifts is necessary to quickly and accurately carry out self-monitoring, sometimes in various and difficult conditions (on mountain trails, on a suspension bridge, when rafting on a mountain river, on the beach). This article presents the development of events on elevated blood levels in children and adolescents with DM1 in the conditions of the marathon, running at various distances in the conditions of the summer shift in the Moscow region of the children’s health camp ANO “Children’s Camp FOX CAMP (Lager’ Lisonok)”.
Clinical features of dry eye syndrome and evaluation of the effectiveness of artificial tear therapy in patients with anxiety and depression after cataract and keratorefractive surgery
Authors: Korneeva A. V. , Strakhova S. S. , Loskutov I. A. 
Published: August 2023

Introduction. Dry eye syndrome (DES) is a common cause of blurred vision and discomfort in patients after eye surgery, which has a great impact on the on the patients’ mental state. Evaluation of the presence of DES during the preoperative examination is important not only for obtaining a high postoperative result, but also for the timely administration of therapy in order to improve the patient's quality of life.Aim. Thus, the aim of this study was to establish the features of the clinical course of dry eye syndrome and to determine the effectiveness of ultra-high viscosity hyaluronic acid therapy in patients with anxiety and depression after cataract and keratorefractive surgery.Materials and methods. The study involved 100 patients (150 eyes). Preoperative examination included DES diagnostic and psychotesting. DES in all studied subjects was treated with ultra-high viscosity hyaluronic acid 3 times a day for 3 months after surgery in combination with topical combination of glucocorticoids, antibacterial and non-steroidal anti-inflammatory drugs, which were administered within 1 week after surgery. There were no intraoperative complications in all studied cases.Results. It was found that patients with depressive and/or anxiety symptoms (46% of the subjects) had higher OSDI scores, while there were no differences in clinical and functional tests of dry eye syndrome between the studied groups. There was a significant improvement in the results of OCT meniscometry and Norn's test during therapy with ultra-high viscosity hyaluronic acid. The given clinical examples show the importance of timely diagnosis and treatment of DES.Conclusions. The study showed the importance of dry eye syndrome evaluation and timely artificial tear therapy prescribing for both to achieve a high postoperative result and to reduce the patients’ subjective discomfort and improve patients’quality of life.
Efficacy of zolmitriptan nasal spray in adult patients with migraine
Authors: Amelin A. V. , Vaganova I. S. , Koreshkina M. I. , Tereshchenko N. M. 
Published: August 2023

Introduction. Migraine is a common disabling condition. Migraine patients require fast-acting drugs with high efficacy. Prior studies have demonstrated that zolmitriptan oral dosage forms (oral tablets) are highly effective in the treatment of migraine attacks.Aim. To evaluate the efficacy, timing of onset of therapeutic effect and tolerability of zolmitriptan nasal spray (Xsenza®) in the treatment of migraine.Materials and methods. A total of 39 patients aged 20 to 58 years with migraine were enrolled in a prospective, multicentre, observational study. Patients were included in a group to treat three consecutive migraine attacks with zolmitriptan nasal spray at a dose of 2.5 mg according to their habitual behaviour model that most closely reflects clinical practice. Efficacy endpoint (positive attack treatment outcome) was the generally accepted measure of reduction in cephalalgia intensity and concomitant autonomic symptoms (reduction in pain and autonomic symptoms from severe/moderate to mild/absence severity according to VAS) 2 hours after zolmitriptan inhalation.Results. The absence or mild intensity of headache was reported in 25% of patients 10 minutes (earliest assessment in that study) and in 28% of patients 30 minutes after administration of the drug. The proportion of patients with positive treatment outcomes in all three consecutive migraine attacks two hours after administration of zolmitriptan nasal spray 2.5 mg was 69.2%, 75% and 75%, respectively. Zolmitriptan nasal spray was well tolerated, while most adverse events were mild in severity and transient in nature.Conclusions. Zolmitriptan nasal spray (Xsenza®) is highly effective in the treatment of migraine attacks and has a rapid onset of action. The drug combines high efficacy and good tolerability.
Fog water harvesting potential and its use in supplementary irrigation of rainfed crops (winter wheat) in Abi-beyglu, Ardabil (Iran)
Authors: Kanooni Amin , Kohan Mohammad Reza 
Published: August 2023

Abstract

In arid and semi-arid areas where available water resources are very limited, the application of unconventional sources of water like the fog is of paramount importance. In this paper, the feasibility of using a standard fog collector (SFC) to collect fog water for complementary irrigation of rainfed wheat in the Abi-beyglu area was investigated. For this purpose, collected water volume was measured on a daily basis during fog time in 2021. The water demand of the winter wheat was estimated by the FAO Penman–Monteith equation under dry and normal conditions. Then the contribution of the collected water to supply the water demand of the wheat and the resultant increase in the yield under two different scenarios, namely complementary irrigation with 30 and 60 mm of collected water, was estimated using the AquaCrop model. Results showed that it is feasible to obtain an average water production of 3.6 L/m2/day over the studied period. Upon irrigation with 30 and 60 mm of collected water under dry and normal conditions, 26 and 34% of the water deficiency for wheat farming was supplied, leading to increased crop yields by 0.6 and 1.7 ton/ha, respectively.
Ensayo de biocompatibilidad con Artemia salina para cinco materiales de uso endodóntico
Authors: Torres-Avirama Leidy Johanna , Realpe-Urbano Daniela Alexandra , Guevara-Valencia Tania Lizeth , Morales Gilbert Alfonso , Zamora-Córdoba Ingrid Ximena , Valencia-Llano Carlos Humberto 
Published: August 2023

Introducción: la biocompatibilidad es un factor decisivo para el éxito de una terapia endodoncica. Objetivo: evaluar la citotoxicidad de cinco materiales de uso endodóntico mediante la prueba de Artemia Salina. Método: se diseñó un estudio experimental in vitro, empleando Artemia salina, para evaluar la biocompatibilidad de los cementos Grossman, CaOH, AH-Plus, MTA y TheraCal-LC con observaciones a 24 y 48 horas. Resultados: los resultados indican que el cemento Grossman presenta un 100% de toxicidad a las 24 horas, mientras que los demás materiales muestran valores menores al 30%, reflejando un comportamiento biocompatible, sin embargo, a las 48 horas, CaOH y TheraCal-LC presentan una toxicidad mayor al 30%, mientras que AH-Plus y MTA continúan con valores -menores del 30%. Los datos fueron analizados con un Modelo lineal generalizado con distribución de errores binomial, un análisis de devianza, y la prueba de comparación múltiple de Fisher con corrección Bonferroni. Se hizo un análisis independiente para las 24 y 48 horas, bajo un nivel de significancia α=5%, se encontraron diferencias significativas a las 48 horas entre TheraCal-LC y AH-Plus y MTA. Conclusión: se concluye que el cemento Grossman presentó un alto grado de toxicidad, mientras que AH-Plus y MTA mostraron la mayor biocompatibilidad
Bajo peso al nacer en Colombia según condiciones socioeconómicas de la madre
Authors: Mestre-Mestre Mauricio Andrés , Escobar-Velásquez Katty Dayana 
Published: August 2023

Introducción: los recién nacidos con bajo peso al nacer (BPN) tienen 20 a 40 veces más probabilidad de morir que recién nacido con peso normal. El objetivo del estudio fue establecer las características socioeconómicas de las madres asociadas al BPN en Colombia según los datos de la Encuesta Nacional de Demografía y Salud. Métodos: Se realizó análisis secundario de la ENDS 2015. Se calcularon las asociaciones entre las características socioeconómica de la madre y el BPN. Resultados: la distribución por género, mostró un predominio del sexo femenino, presentando una prevalencia de BPN mayor que el masculino (9.50% vs 8.29%).Se observó diferencias significativa en las prevalencias de BPN por edad (p- valor 0.002) con mayor prevalencia de la condición en madres en edades extremas (OR 1,29 IC 95% 1,10 -1,51 ) y nivel educativo de la madre( OR 1,11 IC 95% 0,949445- 1,306799 ), Conclusión: se concluye que el BPN es más probable en recién nacidos femeninas de madres cuyas edades sean menores de 20 años o mayores de 40 años con nivel educativo inferior al pregrado. Se recomienda identificar tendencias en el comportamiento del BPN contratando estos resultados con la próxima versión de ENSIN.
School Gardens in Poland – Rediscovered Places
Authors: Ziemkowska Joanna 
Published: August 2023

School gardens have been present in the educational space of the Polish school for many years. In recent decades, however, they have ceased to be appreciated. Efforts have been made to modernize laboratories, they have been equipped with measuring instruments, digital devices and multimedia equipment. A natural laboratory, which a garden in fact is, has become a symbol of the past. It remained only in few schools, performing rather an aesthetic function, less often didactic or educational one. The present article depicts a historical outline, shows earlier and currently noticed possibilities of using school gardens in Poland. An analysis of previous studies on gardens is presented as well. A contemporary design of a school garden was proposed to prepare students of pedagogical faculties for activities in the garden with children. School gardens may contribute to the prevention of “nature deficit” (Louv 2014, 54), they may give a sense of closeness to nature also in urban realities[1]. M. Vogt-Kostecka notes that the fear of dirt, wind and ticks limits children's free play in a meadow and in a forest. Limited access to nature is particularly visible among urban children (Vogt-Kostecka 2017, 11). Gradually, the view of school gardens has been changing and their therapeutic potential (hortitherapy) is noticed.

[1] According to R. Louv, the nature deficit is manifested in problems with concentration of attention, hyperactivity, and reduced psychophysical fitness.
Anticancer Effect of Dihydroartemisinin via Dual Control of ROS-induced
Apoptosis and Protective Autophagy in Prostate Cancer 22Rv1 Cells
Authors: Yang Jiaxin , Xia Tong , Zhou Sijie , Liu Sihao , Pan Tingyu , Li Ying , Luo Ziguo 
Published: August 2023

Background:
Dihydroartemisinin (DHA), a natural agent, exhibits potent anticancer
activity. However, its biological activity on prostate cancer (PCa) 22Rv1 cells has not been previously
investigated.

Objective:
In this study, we demonstrate that DHA induces anticancer effects through the induction
of apoptosis and autophagy.

Methods:
Cell viability and proliferation rate were assessed using the CCK-8 assay and cell clone
formation assay. The generation of reactive oxygen species (ROS) was detected by flow cytometry.
The molecular mechanism of DHA-induced apoptosis and autophagy was examined using
Western blot and RT-qPCR. The formation of autophagosomes and the changes in autophagy flux
were observed using transmission electron microscopy (TEM) and confocal microscopy. The effect
of DHA combined with Chloroquine (CQ) was assessed using the EdU assay and flow cytometry.
The expressions of ROS/AMPK/mTOR-related proteins were detected using Western blot.
The interaction between Beclin-1 and Bcl-2 was examined using Co-IP.

Results:
DHA inhibited 22Rv1 cell proliferation and induced apoptosis. DHA exerted its antiprostate
cancer effects by increasing ROS levels. DHA promoted autophagy progression in 22Rv1
cells. Inhibition of autophagy enhanced the pro-apoptotic effect of DHA. DHA-induced autophagy
initiation depended on the ROS/AMPK/mTOR pathway. After DHA treatment, the impact of Beclin-
1 on Bcl-2 was weakened, and its binding with Vps34 was enhanced.

Conclusion:
DHA induces apoptosis and autophagy in 22Rv1 cells. The underlying mechanism
may involve the regulation of ROS/AMPK/mTOR signaling pathways and the interaction between
Beclin-1 and Bcl-2 proteins. Additionally, the combination of DHA and CQ may enhance the efficacy
of DHA in inhibiting tumor cell activity.
Male Breast Cancer: Three Case Reports and a Literature Review
Authors: Xin Yuanfang , Wang Fengmei , Ren Dengfeng , Zhao Fuxing , Zhao Jiuda 
Published: August 2023

Introduction:
Male breast cancer (MBC) accounts for 0.5%-1% of all breast cancers diagnosed worldwide.
However, its biological characteristics can be distinguished from that of female breast cancer (FBC)

Case Representation:
The diagnostic and treatment approaches for MBC are mainly similar to that of FBC due to the
lack of male breast cancer-related studies, clinical trials, and literature. An increasing number of retrospective and
prospective studies have been conducted to clarify the individualized care for MBC. Herein, we report three cases of
advanced MBC to describe the diagnostic approaches, treatment process, and survival prognosis.

Conclusion:
MBC patients had older age, later stage at first diagnosis, higher expression of hormone receptors, and
poor prognosis. A literature review was conducted to determine the incidence, risk factors, disease features, diagnosis,
treatment, survival, and management of MBC.
Therapeutic and Phytochemical Properties of Thymoquinone Derived
from Nigella sativa
Authors: Tiwari Gaurav , Gupta Monisha , Devhare Lalchand D. , Tiwari Ruchi 
Published: August 2023

Background:
Nigella sativa (N. sativa), commonly known as black seed or black cumin,
belongs to the family Ranunculaceae. It contains several phytoconstituents, Thymoquinone
(TQ), thymol, thymohydroquinone, carvacrol, and dithymoquinone. TQ is the main phytoconstituent
present in N. sativa that is used as an herbal compound, and it is widely used as an antihypertensive,
liver tonic, diuretic, digestive, anti-diarrheal, appetite stimulant, analgesic, and antibacterial
agent, and in skin disorders.

Objective:
The study focused on collecting data on the therapeutic or pharmacological activities of
TQ present in N. sativa seed.

Methods:
Antidiabetic, anticancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory,
hepato-protective, renal protective, and antioxidant properties of TQ have been studied by various
scientists.

Conclusion:
TQ seems to have a variety of consequences on how infected cells behave at the cellular
level.
Characteristics of patients with decompression illness at the hyperbaric polyclinic of Prof IGNG Ngoerah General Hospital Bali before the COVID-19 pandemic
Authors: Indah Carolin Tiara Lestari , Arimbawa I Komang , Widyantara I Wayan , Laksmidewi Agung Ayu Putri , Putra Ida Bagus Kusuma , Devi Anita 
Published: August 2023

Decompression illness (DCI) is an injury suffered by divers due to the formation of nitrogen bubbles in the bloodstream and tissues during or after a pressure drop in the surrounding environment when diving. Bali is one of the most famous diving spots in Southeast Asia and also has a Hyperbaric Oxygen Therapy (HBOT) center in Prof. IGNG Ngoerah General Hospital. This study aims to determine the characteristic of DCI patients at the Hyperbaric Polyclinic in Prof. IGNG Ngoerah General Hospital, Denpasar, Bali before the COVID-19 pandemic. A descriptive retrospective study has conducted by descriptive retrospective by collecting administrative data at the Hyperbaric Polyclinic of Prof. IGNG Ngoerah General Hospital in 2018-2019. The required examination data are demographic data, diver profiles, DCI characteristics, and the previous therapy. Data analysis using SPSS Version 24. Most DCI patients in this study were foreigner (88.1%), men (53.2%), normal BMI (37.3%), no prior history of disease (88.9%), diving depth >20 meters (n=79, 62.7%), average surface interval 101,184 minutes (30-1440 minutes), diving duration 1-3 hours (n=69.54.8%), DCI type 2 (58.7%) with major severity (57.9%). Of the overall patients, 14.3% rapid ascent, 2.4% panicked while diving, 10.3% made flights and 6.3% climbed after diving.
Konferencja o ochronie obszarów wodno- -błotnych w Polsce z okazji Światowego Dnia Mokradeł (4–7 luty 2023, Warszawa)
Authors: Kapler Adam 
Published: August 2023

Mokradła były osuszane przez tysiąclecia. Od ponad wieku wiele z nich chroni się jednak jako rezerwaty, parki narodowe i/lub tereny Natura 2000. Większość bagien Polski uległa jednak degradacji, toteż warto pomyśleć o ich odtworzeniu. Jest to problem szalenie trudny do rozwiązania, szczególnie w dobie wojny w Ukrainie, rosnącej polaryzacji społecznej wokół NRL [2022], kryzysu humanitarnego na granicy polsko-białoruskiej oraz klęki ekologicznej w Odrze. Dlatego Światowy Dzień Mokradeł 2023, obchodzony corocznie z inicjatywy Centrum Ochrony Mokradeł, w rocznicę podpisania Konwencji z Ramsar, miał w tym roku szczególnie rozbudowany program. Prócz wygłaszanych corocznie debat, wykładów otwartych, prezentacji posterów i wycieczek terenowych w lutym 2023 r. zorganizowano dodatkowo: ściśle naukową, parodniową konferencję o ochronie obszarów wodno-błotnych, dwie wycieczki terenowe tudzież szereg warsztatów dla praktyków. Słowa kluczowe: Światowy Dzień Mokradeł 2023, Konwencja Ramsarska, bagna, zmiany klimatu
Pembelajaran Agama Islam pada Sekolah Dasar Suka Maju Kota Subulussalam (Strategi Pembentukan Akhlakul Karimah)
Authors: Rahmah Siti , Walidin Warul , Masbur Masbur 
Published: August 2023

The aims of this study were: (1) to find out the role of the teacher in learning the Islamic religion in SD Suka Maju, Subulussalam City. (2) To find out the learning strategy applied in SD Suka Maju, Subulussalam City (3) To find out the supporting and inhibiting factors in implementing the akhlakul karimah strategy at SD Suka Maju, Subulussalam City. This study used a qualitative descriptive research method with data collection techniques through interviews, observation, and documents. Data analysis techniques use data reduction, data display, and conclusions or verification. The research location is at SD Suka Maju, Subulussalam City. The results of this study are as follows: 1). The role of the teacher in learning Islamic religion, namely: The teacher carries out his duties as an educator, educates, directs, sets an example or is exemplary, gives advice, reprimands, guides, and gives motivation. And the teacher guides the learning process well and effectively to achieve learning goals. 2). The learning strategies used in Islamic religious education at SD Suka Maju Kota Subulussalam are expository, inquiry learning strategies, problem-based learning strategies, and contextual learning strategies. 3). There are several supporting factors in the formation of Akhlakul Karimah at SD Suka Maju, including Student enthusiasm in the learning process of forming Akhlakul Karimah, Religious activities at school become routines that are carried out at school such as reading Surat Yasin every Friday, Rules that support the realization of the essence of the formation of Akhlakul karimah for SD Suka Maju students, qualified and disciplined teachers, a conducive extracurricular school environment that helps in the formation of Akhlakul karimah for students, and the support and active role of parents and guardians While the inhibiting factors in the formation of Akhlakul Karimah in SD Suka Maju include: different backgrounds of students, lack of interest and enthusiasm of students in learning religion, awareness of less disciplined students, and influence of the environment outside the school.
Analisis Kemampuan Komunikasi Matematika Siswa Ditinjau dari Motivasi Berprestasi
Authors: Aspriyani Riski , Hartono Bryan Pudji 
Published: August 2023

Motivasi untuk berprestasi yang ada dalam diri siswa perlu dirangsang sehingga memberikan perubahan yang lebih baik untuk hasil belajarnya. Hasil belajar matematika salah satunya dapat dilihat pada kemampuan komunikasi matematika siswa dalam menyelesaikan suatu permasalahan matematika yang diberikan. Untuk itu, penelitian deskriptif kuantitatif ini dilakukan dengan tujuan untuk mengetahui perbedaan kemampuan komunikasi matematika siswa ditinjau dari motivasi berprestasi tinggi, sedang, dan rendah. Data diambil menggunakan instrumen tes essay dan angket kepada 67 siswa sebagai responden di SMA Negeri 1 Purbalingga tahun 2021. Sampel tersebut diperoleh menggunakan teknik purposive sampling. Analisis data menggunakan statistika deskriptif dan inferensial. Pada statistika inferensial digunakan uji Analysis of Variance (ANOVA) One Way dengan dan dilanjutkan pasca ANOVA menggunakan Metode Scheffe. Uji hipotesis ANOVA One Way dilakukan dengan prasyarat analisis uji normalitas menggunakan Kolmogorov Smirnov dan Uji Homogenitas. Hasil penelitian diperoleh dengan nilai signifikansi sebesar atau nilai Fh=7,159 > F 0,05;2;64= 3,23 yang berarti bahwa H0 ditolak, artinya terdapat perbedaan kemampuan komunikasi matematika ditinjau dari motivasi berprestasi. Kemudian dilakukan uji lanjut, diperoleh bahwa siswa yang memiliki motivasi berpretasi tinggi mempunyai komunikasi matematika lebih baik dibanding siswa dengan motivasi beprestasi sedang dan rendah. Sedangkan, siswa yang memiliki motivasi berprestasi sedang dan rendah memiliki kemampuan komunikasi matematika sama baiknya.
Pengaruh Model Self Regulated Learning dan Discovery Learning terhadap Kemampuan Berpikir Kreatif Matematis
Authors: Andriyani Emi , Muhaimin Muhaimin , Syaiful Syaiful 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui pengaruh model self regulated learning (SRL) dan model discovery learning terhadap kemampuan berpikir kreatif matematis siswa, pengaruh kepercayaan diri terhadap kemampuan berpikir kreatif matematis, dan interaksi antara model pembelajaran SRL dan discovery learning dengan kepercayaan diri siswa terhadap kemampuan berpikir kreatif. Metode penelitian yang digunakan adalah metode quasi eksperimen. Sampel penelitian terdiri dari atas 32 orang siswa di kelas eksperimen I, 32 orang siswa di kelas eksperimen II, dan 32 orang pada kelas kontrol. Pengumpulan data dilakukan dengan pemberian angket dan soal tes tertulis. Analisis data yang digunakan adalah teknik anova dua arah. Hasil penelitian menunjukan bahwa model SRL lebih efektif mempengaruhi kemampuan berpikir kreatif dibandingkan model discovery learning dan model konvensional. Kepercayaan diri siswa pada level tinggi dan sedang lebih efektif dalam mempengaruhi kemampuan berpikir kreatif dibandingkan kepercayaan diri rendah. Terdapat interaksi antara model SRL dan DL dengan kepercayaan diri dalam mempengaruhi kemampuan berpikir kreatif.