bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of miR-219-5p in relation to mortality in patients with small cell lung cancer: a retrospective, observational cohort study in China
Authors: Wu Xiangmei , Zhang Jigang , Zhang Xiaohui , Xiang Mengqi , Xu Zhihua , Cao Zhijun 
Published: March 2023

ObjectivesSmall cell lung cancer (SCLC) is a lethal human malignancy, and previous studies support the contribution of microRNA to cancer progression. The prognostic value of miR-219-5p in patients with SCLC remains unclear. This study aimed to evaluate the predictive value of miR-219-5p with respect to mortality in patients with SCLC and to incorporate miR-219-5p level into a prediction model and nomogram for mortality.DesignRetrospective observational cohort study.Setting and participantsOur main cohort included data from 133 patients with SCLC between 1 March 2010 and 1 June 2015 from the Suzhou Xiangcheng People’s Hospital. Data from 86 patients with non-SCLC at Sichuan Cancer Hospital and the First Affiliated Hospital of Soochow University were used for external validation.Outcome measuresTissue samples were taken during admission and stored, and miR-219-5p levels were measured at a later date. A Cox proportional hazard model was used for survival analyses and for analysing risk factors to create a nomogram for mortality prediction. The accuracy of the model was evaluated by C-index and calibration curve.ResultsMortality in patients with a high level of miR-219-5p (≥1.50) (n=67) was 74.6%, while mortality in the low-level group (n=66) was 100.0%. Based on univariate analysis, we included significant factors (p<0.05) in a multivariate regression model: patients with high level of miR-219-5p (HR 0.39, 95% CI 0.26–0.59, p<0.001), immunotherapy (HR 0.44, 95% CI 0.23–0.84, p<0.001) and prognostic nutritional index score >47.9 (HR=0.45, 95% CI 0.24–0.83, p=0.01) remained statistically significant factors for improved overall survival. The nomogram had good accuracy in estimating the risk, with a bootstrap-corrected C-index of 0.691. External validation indicated an area under the curve of 0.749 (0.709–0.788).ConclusionsThe miR-219-5p level was associated with a reduced risk of mortality in patients with SCLC. A nomogram incorporating MiR-219-5p level and clinical factors demonstrated good accuracy in estimating the risk of overall mortality. Prospective validation of the prognostic nomogram is needed.
Arterial hypertension and its covariates among nomadic Raute hunter-gatherers of Western Nepal: a mixed-method study
Authors: Koirala Tapendra , B C Udaya Bahadur , Shrestha Carmina , Paudel Ujjawal , Dhital Rolina , Pokharel Sunil , Subedi Madhusudan 
Published: March 2023

ObjectivesTo determine the prevalence of, and understand the factors associated with, hypertension among the nomadic Raute hunter-gatherers of Western Nepal.DesignA mixed-method study.SettingThe study was carried out at Raute temporary campsites in the Surkhet District of Karnali Province between May and September 2021.ParticipantsThe questionnaire-based survey included all males and non-pregnant females of the nomadic Raute group aged 15 years and above. In-depth interviews were conducted among purposively selected 15 Raute participants and four non-Raute key informants to help explain and enrich the quantitative findings.Outcome measuresThe prevalence of hypertension (defined as brachial artery blood pressure of systolic ≥140 mm Hg and/or diastolic ≥90 mm Hg) and its sociodemographic, anthropometric and behavioural covariates.ResultsOf the 85 eligible participants, 81 (median age 35 years (IQR: 26–51), 46.9% female) were included in the final analysis. Hypertension was found in 10.5% of females, 48.8% of males and 30.9% of the total population. Current alcohol and tobacco use were high (91.4% and 70.4%, respectively), with concerning high rates among youths. Males, older people, current drinkers and current tobacco users were more likely to have hypertension. Our qualitative analysis suggests that the traditional forest-based Raute economy is gradually transitioning into a cash-based one that heavily relies on government incentives. Consumption of commercial foods, drinks and tobacco products is increasing as their market involvement grows.ConclusionThis study found a high burden of hypertension, alcohol and tobacco use among nomadic Raute hunter-gatherers facing socioeconomic and dietary transitions. Further research is needed to assess the long-term impact of these changes on their health. This study is expected to help appraise concerned policymakers of an emerging health concern and formulate context-specific and culturally sensitive interventions to limit hypertension-related morbidities and mortalities in this endangered population.
Pharmacological Emergency management of Agitation in Children and Young people: protocol for a randomised controlled trial of intraMuscular medication (PEAChY-M)
Authors: Bourke Elyssia M , Borland Meredith L , Kochar Amit , George Shane , Shellshear Deborah , Jani Shefali , Perkins Kent , Tham Doris , Gordon Michael Solomon , Klein Kate , Prakash Chidambaram , Lee Katherine , Davidson Andrew , Knott Jonathan C , Craig Simon , Babl Franz E 
Published: March 2023

IntroductionAcute severe behavioural disturbance (ASBD) is a condition seen with increasing frequency in emergency departments (EDs) in adults and young people. Despite the increasing number of presentations and significant associated risks to patients, families and caregivers, there is limited evidence to guide the most effective pharmacological management in children and adolescents. The aim of this study is to determine whether a single dose of intramuscular olanzapine is more effective than intramuscular droperidol at successfully sedating young people with ASBD requiring intramuscular sedation.Methods and analysisThis study is a multicentre, open-label, superiority randomised controlled trial. Young people aged between 9 and 17 years and 364 days presenting to an ED with ASBD who are deemed to require medication for behavioural containment will be recruited to the study. Participants will be randomised in a 1:1 allocation between a single weight-based dose of intramuscular olanzapine and intramuscular droperidol. The primary outcome is the proportion of participants who achieve successful sedation at 1-hour post randomisation without the need for additional sedation. Secondary outcomes will include assessing for adverse events, additional medications provided in the ED, further episodes of ASBD, length of stay in the ED and hospital and satisfaction with management.Effectiveness will be determined using an intention-to-treat analysis, with medication efficacy determined as part of the secondary outcomes using a per-protocol analysis. The primary outcome of successful sedation at 1 hour will be presented as a percentage within each treatment group, with comparisons presented as a risk difference with its 95% CIs.Ethics and disseminationEthics approval was received from the Royal Children’s Hospital Human Research Ethics Committee (HREC/69948/RCHM-2021). This incorporated a waiver of informed consent for the study. The findings will be disseminated in a peer-reviewed journal and at academic conferences.Trial registration numberACTRN12621001238864.
Dark matter effects on hybrid star properties
Authors: Lenzi C. H. , Dutra M. , Lourenço O. , Lopes L. L. , Menezes D. P. 
Published: March 2023

AbstractIn the present work, we investigate the effects of dark matter (DM) on hybrid star properties. We assume that dark matter is mixed with both hadronic and quark matter and interacts with them through the exchange of a Higgs boson. The hybrid star properties are obtained from equations of state calculated with a Maxwell prescription. For the hadronic matter, we use the NL3* parameter set, and for the quark matter, the MIT bag model with a vector interaction. We see that dark matter does not influence the phase transition points (pressure and chemical potential) but shifts the discontinuity on the energy density, which ultimately reduces the minimum mass star that contains a quark core. Moreover, it changes considerably the star family mass-radius diagrams and moves the merger polarizability curves inside the confidence lines. Another interesting feature is the influence of DM in the quark core of the hybrid stars constructed. Our results show an increase of the core radius for higher values of the dark particle Fermi momentum.
CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation
Authors: Al-Jazrawe Mushriq , Xu Steven , Poon Raymond , Wei Qingxia , Przybyl Joanna , Varma Sushama , van de Rijn Matt , Alman Benjamin A. 
Published: March 2023

The interaction between neoplastic and stromal cells within a tumor mass plays an important role in cancer biology. However, it is challenging to distinguish between tumor and stromal cells in mesenchymal tumors because lineage-specific cell surface markers typically used in other cancers do not distinguish between the different cell subpopulations. Desmoid tumors consist of mesenchymal fibroblast-like cells driven by mutations stabilizing beta-catenin. Here we aimed to identify surface markers that can distinguish mutant cells from stromal cells to study tumor–stroma interactions. We analyzed colonies derived from single cells from human desmoid tumors using a high-throughput surface antigen screen, to characterize the mutant and nonmutant cells. We found that CD142 is highly expressed by the mutant cell populations and correlates with beta-catenin activity. CD142-based cell sorting isolated the mutant population from heterogeneous samples, including one where no mutation was previously detected by traditional Sanger sequencing. We then studied the secretome of mutant and nonmutant fibroblastic cells. PTX3 is one stroma-derived secreted factor that increases mutant cell proliferation via STAT6 activation. These data demonstrate a sensitive method to quantify and distinguish neoplastic from stromal cells in mesenchymal tumors. It identifies proteins secreted by nonmutant cells that regulate mutant cell proliferation that could be therapeutically.

Significance:
Distinguishing between neoplastic (tumor) and non-neoplastic (stromal) cells within mesenchymal tumors is particularly challenging, because lineage-specific cell surface markers typically used in other cancers do not differentiate between the different cell subpopulations. Here, we developed a strategy combining clonal expansion with surface proteome profiling to identify markers for quantifying and isolating mutant and nonmutant cell subpopulations in desmoid tumors, and to study their interactions via soluble factors.
Interdependent Self-Organizing Mechanisms for Cooperative Survival
Authors: Scott Matthew , Pitt Jeremy 
Published: March 2023

AbstractCooperative survival “games” are situations in which, during a sequence of catastrophic events, no one survives unless everyone survives. Such situations can be further exacerbated by uncertainty over the timing and scale of the recurring catastrophes, while the resource management required for survival may depend on several interdependent subgames of resource extraction, distribution, and investment with conflicting priorities and preferences between survivors. In social systems, self-organization has been a critical feature of sustainability and survival; therefore, in this article we use the lens of artificial societies to investigate the effectiveness of socially constructed self-organization for cooperative survival games. We imagine a cooperative survival scenario with four parameters: scale, that is, n in an n-player game; uncertainty, with regard to the occurrence and magnitude of each catastrophe; complexity, concerning the number of subgames to be simultaneously “solved”; and opportunity, with respect to the number of self-organizing mechanisms available to the players. We design and implement a multiagent system for a situation composed of three entangled subgames—a stag hunt game, a common-pool resource management problem, and a collective risk dilemma—and specify algorithms for three self-organizing mechanisms for governance, trading, and forecasting. A series of experiments shows, as perhaps expected, a threshold for a critical mass of survivors and also that increasing dimensions of uncertainty and complexity require increasing opportunity for self-organization. Perhaps less expected are the ways in which self-organizing mechanisms may interact in pernicious but also self-reinforcing ways, highlighting the need for some reflection as a process in collective self-governance for cooperative survival.
Human-Animal Reincarnation and Animal Grief in Kabbalah: Joseph of Hamadan’s Contribution
Authors: Sachs-Shmueli Leore 
Published: March 2023

Abstract
In thirteenth-century Castile, the kabbalist R. Joseph of Hamadan offered an unprecedented articulation of the idea of reincarnation (gilgul), proposing that Jewish men could be reborn as gentiles, women, or even animals. This article studies the formation of the Jewish belief in the transmigration of human souls into animal bodies, focusing on the question of animal pain. It contextualizes the kabbalistic literary treatment of animals by examining the thirteenth-century European genre of bestiaries, which attempted to instill proper morals in readers by associating animals with sinners. Although the idea of animal reincarnation led kabbalists to treat animals as creatures with human souls, it did not lead to a fundamental or radical shift in the treatment of animals.
A Musical Mash-Up of Phrynichus Tragicus and New Music in Aristophanes’ Birds
Authors: Lewis Amy S. 
Published: March 2023

Abstract
I argue that in the ode and antode of Birds (737–52 and 769–84), Aristophanes presents a ‘mash-up’ of the early tragic songs of Phrynichus and the late fifth-century New Music. I analyze the comic presentation of both in Aristophanes and other comic poets to show that while they are contextually distinct, there is evidence of some musical congruity that renders them a fitting pair for combination in a mash-up. Regarding the ode and antode of Birds, I argue that despite the Phrynichean style of the songs, their meta-musical discourse shows a New Music poetics. I identify the New Musical aspect of the songs in the figure of the nightingale-aulete and the bird-noise refrains. Contextualizing the mash-up in the comic plot, I suggest that it constitutes a comic musical commentary on the play’s politics.
The Evolutionary Pentatonism in Nicomachus, the Extant Fragments and an Ancient Greek Musical Praxis
Authors: Katsanevaki Athina 
Published: March 2023

Abstract
Pentatonism in ancient Greek music refers to so called ‘gapped scales’, quoted by Pseudo-Aristotle, Pseudo-Plutarch, Nicomachus and Aristides Quintilianus. In the case of Nicomachus, the interchangeabilities of pitches and positions of notes, with the musical nomenclature, make the text incomprehensible. These extracts have already been analyzed by Chailley (1956, 1968), Barker (1989, 2007) and Franklin (2019). It is important though, to shift from the Western concept of music in order to unfold the musical process revealed in the texts. Ethnomusicological research reveals a network of musical dialects which follows an evolutionary process and suggests new possible interpretations: it breaks down the predominant concept of the theory of the cycle of the fifths and leads to a ‘flexible’ pentatonism, produced by focal points created by a ‘building up’ or ‘making’ of musical scales. Additionally, the critical approach of the extant fragments in the environs of the field of Ethnomusicology offers new interpretations for an ancient Greek musical praxis.
The Political and Religious Context of Juvenile Punishment: A Multilevel Examination of Juvenile Court Dispositions in Three Southern States
Authors: Zane Steven N. , Pupo Jhon A. 
Published: March 2023

Objectives We examine the relationship between political and religious context and juvenile court dispositions, including whether case-level indicators of focal concerns are moderated by community politics and religion. Methods Using a sample of 55,328 juvenile defendants across 175 counties in three states, we first employ multilevel modeling to estimate the direct effects of political and religious context on odds of placement. Second, we examine cross-level interactions between political and religious context, on the one hand, and major case-level predictors of placement, on the other. Results We found mixed support for the hypotheses. While neither political nor religious context were directly associated with odds of placement, religious context moderated several case-level effects. Specifically, findings indicated that violent offenders were punished more harshly in more religious and more religiously homogeneous counties, defendants with a prior record were punished less harshly in more religious and more religiously homogenous counties, Hispanic defendants were punished less harshly in more evangelical counties, and male defendants were punished less harshly in more religiously homogeneous counties. Conclusion Juvenile punishment varies across different courts and systems, yet major contextual hypotheses for this variation (e.g., minority threat) have received limited empirical support. Our findings indicate that other aspects of community context, most notably religiosity, may moderate the relationship between case-level factors and juvenile court punishment.
Risk factors for elective and emergency oxygenator exchanges during veno-venous extracorporeal membrane oxygenation
Authors: van Minnen Olivier , Oude Lansink-Hartgring Annemieke , Hoffmann Roland F , van den Bergh Walter M 
Published: March 2023

Background Despite systemic anticoagulation and antithrombotic surface coating, oxygenator dysfunction remains one of most common technical complications of Extracorporeal membrane oxygenation (ECMO). Several parameters have been associated with an oxygenator exchange, but no guidelines for when to perform an exchange are published. An exchange, especially an emergency exchange, has a risk of complications. Therefore, a delicate balance between oxygenator dysfunction and the exchange of the oxygenator exists. This study aimed to identify risk factors and predictors for elective and emergency oxygenator exchanges. Methods This observational cohort study included all adult patients supported with veno-venous extracorporeal membrane oxygenation (V-V ECMO). We compared patients’ characteristics and laboratory values of patients with and without an oxygenator exchange and between an elective and emergency exchange, defined as an exchange outside office hours. Risk factors for an oxygenator exchange were identified with cox regression analyses, and risk factors for an emergency exchange were identified with logistic regression analyses. Results We included forty-five patients in the analyses. There were twenty-nine oxygenator exchanges in nineteen patients (42%). More than a third of the exchanges were emergency exchanges. Higher partial pressure of carbon dioxide (PaCO2), transmembrane pressure difference (ΔP), and hemoglobin (Hb) were associated with an oxygenator exchange. Lower lactate dehydrogenase (LDH) was the only risk factor for an emergency exchange. Conclusion Oxygenator exchange is frequent during V-V ECMO support. PaCO2, ΔP and Hb were associated with an oxygenator exchange and lower LDH with the risk of an emergency exchange.
Outcomes of a Pharmacy-Driven Inpatient Chronic Obstructive Pulmonary Disease (COPD) Transitions of Care (TOC) Management Process
Authors: Roberts Aaron , Ball Meredith Hope , Bentley Austin Clark , Rafferty Aubrie 
Published: March 2023

Background: Current data shows 30% of patients hospitalized for Chronic Obstructive Pulmonary Disease (COPD) exacerbation are readmitted within 30 days. Medication management during transitions of care (TOC) has shown impact on clinical outcomes, however there is insufficient data to suggest how pharmacy TOC services might benefit this patient population. Objective: Evaluate the effects of pharmacy-driven COPD TOC services on hospital re-presentation rates. Methods: A single-center retrospective chart review conducted of patients hospitalized for a COPD exacerbation. A comprehensive admission-to-discharge TOC service was provided by early immersion pharmacy students, advanced immersion pharmacy students, and an attending pharmacist in a layered learning model. The primary outcome was 30-day re-presentation rate. Secondary outcomes were 90-day re-presentation rate, volume of interventions made and description of the service. Results: From 1/1/2019 to 12/31/2019, there were 2422 patients admitted for COPD exacerbation management and 756 patients received at least one intervention from the COPD TOC service. 30% needed a change to inhaler therapy. The provider accepted 57.8% of the recommended changes, and 36% and 33% of eligible patients received an inhaler technique education and bedside delivery of the new inhaler, respectively. Outcomes in the 30-day re-presentation and 90-day censored re-presentation rates for the intervention and control group were 28.5% vs 25.5% ( P = .12) and 46.7% vs 42.9%, respectively. Conclusion: This study did not find a significant change in 30-day re-presentation rate with a pharmacy-driven COPD TOC service. It did find that a significant number of patients admitted with COPD exacerbation may need an inhaler change, and demonstrates the utility of this kind of TOC service for identifying and correcting medication-related problems unique to this disease state. There were opportunities for improvement in percent of patients receiving the full intended intervention.
Knowledge, attitudes and experience of physicians working in Chile toward the prescription of pre-exposure prophylaxis (PrEP): A cross-national survey
Authors: Orozco-Chinome Javier E , Picón-Jaimes Yelson A , Lozada-Martinez Ivan D , Molina-Franky Jessica , Bolaño Romero Maria P , Acevedo-López Doménica 
Published: March 2023

Background Pre-exposure prophylaxis (PrEP) involves administering antiretroviral drugs to prevent human immunodeficiency virus (HIV) infection in at-risk subjects. Chile is considered one of the countries with the highest number of new cases per year of HIV infections. Methods A nationwide cross-sectional study was carried out in Chile. A questionnaire of physicians' attitudes toward the prescription of PrEP was used. Results 632 doctors responded correctly the survey. 58.5% ( n = 370) were women, and median age was 34 years (IQR 25–43). 55.4% ( n = 350) responded that they have never prescribed antiretrovirals for HIV-negative individuals to prevent HIV infection, and only 10.1% have prescribed PrEP. 60.8% ( n = 384) mentioned having informed about the possibility of using antiretroviral post-exposure prophylaxis in case of risky sexual activity. 76.3% ( n = 482) believed each institution should formulate internal protocols for administering these drugs, and 98.4% ( n = 622) stated that with the currently available evidence, PrEP should be suggested to cope with the HIV pandemic. Conclusion It was concluded that knowledge, attitudes and experience toward PrEP prescribing are variable and related to patient care. However, Chile has a marked tendency in favor of this therapy, which is similar to that reported in studies worldwide.