bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of the antiulcerogenic activity of cryopreserved placenta extract in acute and chronic lesions of the stomach
Authors: Hladkykh F. V. , Koshurba I. V. , Chyzh M. O. 
Published: April 2023

To date, Ukraine has registered about 5 million patients with ulcer disease, and the market of drugs with proven anti-ulcer activity exceeds 500 names, but the problem of effective therapy is far from being solved. Cryoextract of the placenta attracted our attention as a new domestic biotechnological anti-ulcer agent.
The purpose of the study. To characterize the antiulcer activity of cryoextract of human placenta in acute and chronic ulcerogenesis.
Materials and methods. Studies of antiulcer activity were carried out on 56 male rats weighing 200–220 g in two stages: on the model of acute serotonin ulcerogenesis (28 rats) under the therapeutic and prophylactic regimen of placenta cryoextract and on the model of chronic acetic acid damage to the stomach (28 rats) under the therapeutic regimen application of the specified cryoextract.
Results and discussion. The study showed that the therapeutic and prophylactic injection of the cryoextract of the placenta shows a pronounced antiulcer activity in the model of serotonin-induced gastric damage, which was indicated by a decrease in the ulcer index by 13.7 times compared to a similar indicator in the group of untreated animals and was 0.3 and 4, respectively. 1. Hemorrhagic lesions of the gastric mucosa occurred twice as often against the background of placenta cryoextract administration, respectively, against the background of esomeprazole administration – in 57.1% of rats, and against the background of placenta cryoextract administration – in 28.6% of rats. It was established that the investigated cryoextract has a cytoprotective effect on the mucous membrane of the stomach against the background of acetic acid damage. This was indicated by a statistically significant (p<0.05) decrease in the ulcer index by 30.0% compared to the indicators of untreated animals.
Conclusions. It was established that the cryoextract of the human placenta has pronounced antiulcer activity both in acute and chronic experimental ulcerogenesis, which was indicated by a statistically significant decrease in erosions and ulcers of the gastric mucosa.
THROMBECTOMY IN PATIENTS WITH THROMBOSIS OF ARTERIO-VENOUS FISTULA: CASE SERIES
Authors: Vildanov S. R. , Nykonenko A. O. , Gubka V. O. , Rusanov I. V. , Budagov R. I. 
Published: April 2023

Introduction. Thanks to the use of renal replacement therapy at the current stage of medical development, complete medical and social rehabilitation of patients with end-stage chronic renal failure is possible. The key to effective programmed hemodialysis is the formation of adequate permanent vascular access. Ensuring the optimal use and functioning of permanent vascular access is a multidisciplinary challenge. Currently, none of the known options for permanent vascular access is ideal, but a native arteriovenous fistula meets the requirements to a greater extent. Complications from vascular access for hemodialysis remain relevant for their solution today. The most common complication of vascular access is thrombosis of an arteriovenous fistula. For patients with chronic renal failure who are on programmed hemodialysis, thrombosis of vascular access is a great danger, which ultimately can lead to the impossibility of further hemodialysis and is the main reason for hospitalization and high mortality of this contingent of patients and needs an urgent solution.
Clinical cases. 17 patients underwent thrombectomy from the subcutaneous "fistula". vein of the upper extremity. The age of the patients was 49.0 (44.0-61.0) years. By gender, the studied patients were distributed as follows: women - 9 (53%), men - 8 (47%). Among 17 (100%) operated patients, 12 (71%) had late thrombosis, 5 (29%) had early thrombosis of arteriovenous fistula,. Of 5 (100%) patients with early thrombosis of arteriovenous fistula, thrombectomy was effective in 2 (40%) patients (p=0.038). On the other hand, in 12 (100%) patients with late thrombosis of arteriovenous fistula, thrombectomy was successful in only 4 (33%) cases.
Discussion. The cause of thrombosis of any vascular anastomosis is primarily hyperplasia of the neointima due to the proliferation of smooth muscle cells of the vascular wall. This circumstance leads to the formation of stenosis of the anastomosis, and as soon as the stenosis values become hemodynamically significant (> 50% of the lumen of the vessel), the risk of developing thrombosis increases by more than 50%. Thrombectomy alone is insufficient to restore patency of the permanent vascular access in the long term, as flow-limiting stenosis is present in more than 85% of cases.
Conclusions. Neointimal hyperplasia is the main cause of progressive stenosis of arteriovenous fistula and subsequent thrombosis. Thrombectomy is indicated for thrombosis of arteriovenous fistula in the early postoperative period (up to 30 days after arteriovenous fistula formation). Thrombectomy alone is not enough to restore the patency of the permanent vascular access in the long term, and the final treatment requires its reconstruction at an early stage or the creation of a new arteriovenous fistula.
Peculiarities of the course of the wound process in the treatment of acute paraproctitis in patients with type 2 diabetes
Authors: Milica M. M. , Soldusova V. V. , Postolenko M. D. , Milica K. M. , Chobey S. M. 
Published: April 2023

Objective. The purpose of the study is to reveal the features of the course of the wound process in patients with acute paraproctitis against the background of diabetes.
Methods. An analysis of the results of treatment of acute parаproctitis against the background of diabetes in 328 patients over the past 5 years was carried out.
Results. It was found that these patients are define by extensive tissue damage in area and the predominance of gram-negative bacteria in mixed aerobic flora, the addition of anaerobic flora is the cause of the spread of the purulent process and deep destruction of tissues. The synergism of the aerobic-anaerobic flora in combination with the pathogenetic factors of diabetes contribute to a severe and prolonged course of the inflammatory process, as evidenced by the preservation of a high index of intoxication until the 14th day.
Conclusions. The criteria for choosing the method of operation are based on the localization of the abscess and the main purulent course, its relationship to the elements of the external anal sphincter, the nature of the scarring process in the area of internal diversion and the function of the closing apparatus of the rectum.
Comparative analysis of surgical treatment of patients with locally advanced tumors right anatomical segment of pancreas
Authors: Kopchak V. M. , Shkarban V. P. , Pererva L. O. , Savitskiy A. O. , Kropelnitskiy V. O. , Bylik I. I. , Maslyuk Yu. I. , Mihalchevskiy V. P. 
Published: April 2023

Radical resection of pancreas during pancreatic ductal adenocarcinoma has a favorable effect on the patient’s survival rate and disease prognosis. Performance of PV/SMV resection during pancreatoduodenectomy is a routine procedure in leading pancreatology centers, increasing the possibility of R0 resections.
Purpose of the study. Is to evaluate the criteria for the diagnosis of vascular invasion at the preoperative stage, to increase the proportion of R0 resections.The study included 73 patients with locally advanced tumors of the pancreatic head operated on in the pancreatic surgery department from 2019 to 2022. The range of operations included: Whipple pancreatoduodenectomy, pyloruspreserving pancreatoduodenectomy, and total pancreatoduodenectomy.The presence or suspicion of vascular invasion, the size, and the stage of the tumor at the preoperative stage were diagnosed according to the data of MSCT, MRI, ultrasonography, and endosonography. Histological examination was carried out according to the recommendations of the College of American Pathologist 2020.
The first group 44 of patients who were made pancreatoduodenectomy with resection of PV/SMV, and the second group 29 patients without vascular resection. In the second group, a positive venous (smv) resection margin, R1 resection, had all patients according to the planned histological examination.During the preoperative examination, vascular invasion was suspected in 68,2% of patients in the first group, and 58.6% in the second, 58,6%, (x2 = 0,696; p = 0,403). According to histological examination, damage to the vascular wall was confirmed in 81,8% of cases among the first group of patients.A comparative assessment of the indicators of the two groups indicates that there is no significant difference in tumor size (t = 1,38; p = 0,085), localization, intraoperative data (operation time) (t = 1,19; p = 0,117), the number of postoperative complications (x2 = 0,027; p = 0,869), and the histological type of the tumor. Only intraoperative blood loss had statistical significant.
Conclusions. The nowaday preoperative examination protocol allows diagnosing vascular or suspicion of it with sufficient probability and planning adequate surgical intervention.
Performing a resection of PV/SMV during pancreaticoduodenectomy with pre- or intraoperative suspicion of vascular invasion allows to increase the number of R0 resections and improve the prognosis of the disease.
Dermatoplasty for decompensated forms of varicose veins and post-thrombotic syndrome
Authors: Rusin V. I. , Pavuk F. M. , Kovalchuk I. I. , Nosenko O. A. 
Published: April 2023

Objective(s). In order to improve the results of the treatment of the decompensated form of varicose veins and post-thrombotic syndrome, taking into account the angiosomal theory and using VAC and Magott therapy of the recipient woundof the trophic ulcer, evaluate different methods of dermatoplasty depending on the depth and area of the lesion.
Methods. In the surgical clinic of the regional hospital named after A. Novak, 174 patients with chronic venous insufficiency (CVI) in the stage of lecompensation were under our observation. According to the etiology of the disease, there were 76 patients with varicose desease (VD) (group I), 98 patients with PTS (group II), while 27 patients with PTS had trophic ulcers on both lower extremities. With a trophic ulcer (TU) diameter of up to 10 cm in the I group of patients, 42.1% had the depth of the lesion of the IIst, and in the patients of the IIa group, the depth of the lesion was the IIIrd. was observed in 51.4% of cases. In the 1st group (76) patients, TU was cleaned with the help of VAC therapy in 32 patients, Magott therapy was used in 18 patients. TcpO2 was measured in the angiosomes of the anterior tibial artery (APA), posterior tibial artery (PTA), and peroneal artery (PA), as the corresponding arteries participate in the perfusion of the corresponding skin-muscle flaps
Results. Rejection (lysis) of the graft was observed in 5 (6.6%) patients of the 1st group, and only in patients with dermatoplasty using the vintage method. Graft lysis was observed in 4 (5.6%) patients of the IIa group, in two with the vintage method and in two with split graft transplantation. In the IIb group (both limbs affected), partial lysis of the transplanted perforated split graft was observed in three limbs (6%). No complications were observed when the tissue complex was transplanted freely.
Conclusions. Free flaps are units of tissue that can be transplanted from the donor site to the recipient wound while maintaining its blood supply. Pieces can be classified by the type of blood supply, their tissue composition, the method of transplantation, or the orientation of the vessels. The concept of angiosomes and venosomes explains the blood supply to the recipient wound necessary for the viability of the flap. Various monitoring methods are used to monitor patients after surgery, including assessment of physiological parameters and auxiliary methods (dopplerography, transcutaneous and epidermal oximetry). Factors affecting the viability of transplants after surgery include: thorough surgical intervention, adequate immobilization after surgery, prevention of infection, and adequate vascularization of the recipient wound.
EFEKTIVITAS KONSUMSI DAUN UBI JALAR UNGU TERHADAP PENINGKATAN KADAR HEMOGLOBIN DARAH IBU HAMIL TRIMESTER PERTAMA
Authors: Agustkawati Nurlaila , Yuliastuti Luh Putu , Setianingsih Fitri 
Published: April 2023

Salah satu penyebab kematian ibu tertinggi di Indonesia adalah disebabkan karena perdarahan yang secara tidak langsung di sebabkan oleh kondisi anemia ibu hamil. Kebutuhan zat besi pada ibu hamil akan semakin meningkat, akan tetapi pemberian tablet Fe kadang menimbulkan efek samping mual muntah bagi ibu hamil sehingga mengakibatkan ketidakpatuhan ibu hamil dalam mengkonsumsinya. Penelitian ini bertujuan untuk mengetahui efektifitas peningkatan Hb ibu hamil trimester pertama dengan mengkonsumsi daun ubi jalar. Metode penelitian ini menggunakan pra eksperimen dengan one group only pretest-posttest. Berdasarkan hasil anlisis uji t diperoleh nilai –thitung < ttabel (-11.19 < -2.262) dengan nilai signifikan (0.000) < 0.05 yang artinya ada perbedaan kadar hemoglobin darah ibu hamil trismester pertama sebelum dan setelah mengkonsumsi daun ubi jalar ungu. Hal ini dapat diartikan bahwa mengkonsumsi daun ubi jalar ungu efektif dapat meningkatkan kadar hemoglobin darah ibu hamil trimester pertama. Dilihat dari nilai rata-rata N-Gain adalah 1.056 > 0.7 dapat disimpulkan bahwa konsumsi daun ubi jalar ungu untuk meningkatkan kadar hemoglobin darah ibu hamil memiliki kategori efektivitas yang tinggi. Berdasarkan analisis tersebut daun ubi jalar bisa dikonsumsi sehari-hari sebagai pendamping tablet Fe pada ibu hamil.
Pengembangan Ekonomi Lokal Home Industry Keripik Tempe yang Ramah Lingkungan di Kampung Tematik Keripik Sanan Malang
Authors: Syah Putra Rulliannor 
Published: April 2023

Munculnya kampung-kampung kota tematik ditengah permasalahan permukiman yang kompleks memiliki daya tarik tersendiri, bukan hanya menarik bagi wisatawan dari Kota Malang namun sampai ke luar Kota Malang. Awal mula munculnya Kampung Tematik Keripik Sanan adalah sejak tahun 1970-an, Kampung Tematik Keripik Sanan merupakan kampung yang dikenal sebagai kawasan home industry tempe yang terletak di Kelurahan Purwantoro Kota Malang meliputi 412 industri rumah tangga dengan masing-masing terdiri dari 275 industri rumah tangga pengrajin tempe, 118 industri rumah tangga keripik tempe dan 19 industri rumah tangga tempe dan keripik tempe Usaha masyarakat yang dominan dan menjadi mata pencaharian pokok sebagian besar warga di Kampung ini adalah produksi keripik dan tempe. Kampung Tematik Keripik Sanan menghasilkan produk tempe hingga 1,8 ton per hari. Sehingga, muncul berbagai tantangan terutama berkaitan dengan pengelolaan limbah hasil produksi tempe. Limbah yang dihasilkan adalah limbah cair kedelai dan minyak jelantah yang berasal dari proses perebusan dan proses penggorengan keripik tempe. Rata-rata limbah yang dihasilkan dari 100 kg kedelai adalah 455 liter dan limbah minyak jelantah yang dihasilkan dari 100 kg tempe untuk keripik tempe adalah 3 liter minyak jelantah. Penelitian ini bertujuan untuk pengembangan ekonomi lokal home industry keripik tempe yang ramah lingkungan serta mendukung pengembangan kampung yang berkelanjutan di Kampung Tematik Keripik Sanan. Metode pengumpulan data dilakukan dengan cara survei primer yakni melakukan pengamatan langsung dan wawancara. Analisis yang digunakan adalah deskriptif, Force Field Analysis (FFA) serta penyusunan strategi dengan akar tujuan. Hasil penelitian adalah strategi untuk mengembangkan ekonomi lokal home industry keripik tempe yang ramah lingkungan di Kampung Tematik Keripik Sanan Kota Malang.
Tsarist Counterintelligence in Faces.
Investigators for Especially Important Cases (1908–1915)
Authors: Zverev Vadim , Ivanov Victor 
Published: April 2023

The results of many years of archival search and research work in the federal archives of Russia made it possible to find specific documents that canshed light on the unpublished pages of the personalized history of Russian counterintelligence. The purpose of the article is to reveal new facets of professional competence and previously unheard characteristics of outstanding counterintelligence officers and investigators of the Russian Empire. To implement the author's intention, the following methods of historical knowledge were used: actualization, retrospective, descriptive, biographical analysis, generalization of
independent characteristics, deduction, content analysis.
The achieved conclusions and deductions helped to get closer to a complete picture of the historical and psychological profile of the «cloak and dagger knights», who functioned mainly in the territory of the Privislinsky region (and later in the Active Army) before and during the First World War. The results of
the research conducted in this article can be used in research and teaching activities on the history of domestic state security agencies.
Caesar on the Factors of Success in the War
Authors: Demina Svetlana 
Published: April 2023

This article investigates Caesar’s thoughts about the factors of victory in the war on the basis of his remarks in the «Commentaries on the Gallic War» and the «Commentaries on the Civil War». The influence of the gods, the impact of natural
phenomena, the fortune are the factors of the military success that do not depend on people. The knowledge (scientia), an experience (usus), the valour (virtus) and the spirit (animus, voluntas) of soldiers, as well as a skilful influence of the commander on it and his correct decisions are the factors that depend on people. Caesar does not attribute the activity of the gods to the important factors of victory. In his opinion, the
natural phenomena influence only the military operations at sea and near the river.
According to Caesar, the fortune (fortuna) is important enough, however, the behavior of soldiers and commander is decisive for victory. He describes the influence of fortune, knowledge, experience, valour and spirit of warriors, the decisions and ac-
tions of commander as the universal factors of success that are effective both in battles against barbarians and in conditions of civil war.
Statistical Evaluation of Style Dynamics: Lyrical Poems by V. Nabokov in the Mirror of Parts of Speech
Authors: Andreev Vadim 
Published: April 2023

The article utilizes quantitative methods of analysis to obtain objective indices which make it possible to evaluate a separate text and the style of the author. The author applies the techniques of textometry (analysis of PoS ratio, type of
description, cumulative sum) in order to establish the degree of text stability /dynamics and stability / variability of individual style in general.
The database includes verse texts of Vladimir Nabokov created during different periods of creative activity. Poetry was an essential and inseparable part of his writing (as the writer and poet stated himself) which proves the non-accidental character of parameters of his poetic texts and their high relevance for the
study of his style. Only texts not less than 30 lines are included in the database in order to avoid fluctuations in frequency of linguistic elements and ensure comparability of the research material.
The use of Busemann and variability coefficients made it possible to define the ratio of verbal / nominal description in the texts, while analysis of cumulative sum – the ratio of nouns / verbs in the texts in dynamics (from the beginning to its end). The calculated power function provides precise approximation of the data.
The obtained results support the conclusion about the existence of hidden tendencies in the distribution of words of different parts of speech in Nabokov's text, about the growth of variability of their frequencies in the second period of Nabokov’s creative activity, as well as about steady strengthening of the tendency
of text verbality growth over the lifespan of the poet.
Electrical Losses in Primary Distribution Networks: Case in Holguin Province
Authors: Pérez Alvaro Laurencio , Maliuk Igor R. Pérez , Maliuk Olga Pérez 
Published: April 2023

The electrical losses constitute an indicator of the technical state of the electrical networks, which can reach up to 70% of the total losses that occur in an electrical circuit. In this work, the calculation of the technical losses in 140 electrical distribution networks was carried out in the school belonging to the Holguín province in Cuba. The statistical calculation is performed in order to understand the electrical losses in primary distribution networks of the Holguín province. The method used by Empresa Eléctrica Holguín was acquired for power losses, which considered the number of customers, the maximum demand, and the length belonging to the circuit under study. The Buller equation was used to calculate energy losses, which relates the load and loss factors utilizing a coefficient obtained by statistical considerations. The most affected municipalities were Sagua de Tánamo, Calixto García, and Cacocún, whose losses represented 45% of the total losses. On the other hand, the characteristic coefficient for local primary distribution networks was 0.27.
Simplified modelling of frequency dependent network for converter control system design
Authors: Nesterov Dimitri 
Published: April 2023

<p>The integration of renewable generation in the energy mix has led to a massive penetration of converter-interfaced generators (CIG) in the electrical network. However, CIG's are reported to be susceptible to interactions with electrical resonances and other equipment. It became common practice to conduct electromagnetic transient (EMT) studies to assess these risks, define the mitigation measures and design the control systems. To perform the controllers design efficiently, the EMT analysis can be complemented with an analysis of linearized systems, for which numerous efficient methods have been developed.</p>
<p> The paper presents a method to construct the linearized system which is believed to be sufficiently accurate for being used for controllers tuning, and sufficiently simple to be efficiently used on real-life cases. It takes into account the frequency dependent electrical network, and is based on the approach previously used for torsional analyses, but applied to a wider spectrum. It is illustrated on a simple numerical example, demonstrating the challenges that the electrical resonances might pose on the stability margins. A comparison of the results obtained from linearized model and EMT model is presented, aiming to validate the findings from the linearized model and the proposed approach.</p>