bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extensional Earthquakes in the Absence of Magma in Northern Afar: Insights From InSAR
Authors: La Rosa Alessandro , Raggiunti Martina , Pagli Carolina , Keir Derek , Wang Hua , Ayele Atalay 
Published: May 2023

AbstractIn magma‐rich rifts, normal faulting is commonly thought to be induced by dike intrusions. However, whether fault slip occurs purely tectonically is unclear. An earthquake sequence starting with a Mw 5.5 earthquake occurred in December 2022 in northern Afar, a continental rift near breakup. InSAR measurements show that seismicity was caused by normal faulting alone, without involvement of magma movements. Our best‐fit InSAR models show that conjugate faults ruptured during the seismic sequence with mainly normal dip‐slip and total deformation corresponding to a Mw 5.7 event, in agreement with local seismic recordings. Our models show that tectonic faulting accommodates 26 cm of extension corresponding to ∼30 years of plate spreading without any link to magma. Our observations point toward significant along‐rift variation in the proportion of extension from faulting, potentially caused by along‐rift variations in rate of extension and/or from a spatially and temporally segmented supply of magma.
Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI
Authors: Chen Zhimin , Li Yinshuang , Yuan Ying , Lai Kunmei , Ye Keng , Lin Yujiao , Lan Ruilong , Chen Hong , Xu Yanfang 
Published: May 2023

AbstractHomogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced acute kidney injury (AKI) are poorly understood. Here, we performed single-cell sequencing (scRNA) on mouse kidneys with five common AKI etiologies (CP-Cisplatin, IRI-Ischemia-reperfusion injury, UUO-Unilateral ureteral obstruction, FA-Folic acid, and SO-Sodium oxalate). We constructed a potent multi-model AKI scRNA atlas containing 20 celltypes with 80,689 high-quality cells. The data suggest that compared to IRI and CP-AKI, FA- and SO-AKI exhibit injury characteristics more similar to UUO-AKI, which may due to tiny crystal-induced intrarenal obstruction. Through scRNA atlas, 7 different functional proximal tubular cell (PTC) subtypes were identified, we found that Maladaptive PTCs and classical Havcr1 PTCs but not novel Krt20 PTCs affect the pro-inflammatory and pro-fibrotic levels in different AKI models. And cell death and cytoskeletal remodeling events are widespread patterns of injury in PTCs. Moreover, we found that programmed cell death predominated in PTCs, whereas apoptosis and autophagy prevailed in the remaining renal tubules. We also identified S100a6 as a novel AKI-endothelial injury biomarker. Furthermore, we revealed that the dynamic and active immune (especially Arg1 Macro_2 cells) -parenchymal cell interactions are important features of AKI. Taken together, our study provides a potent resource for understanding the pathogenesis of AKI and early intervention in AKI progression at single-cell resolution.
In vivo metallophilic self-assembly of a light-activated anticancer drug
Authors: Zhou Xue-Quan , Wang Peiyuan , Ramu Vadde , Zhang Liyan , Jiang Suhua , Li Xuezhao , Abyar Selda , Papadopoulou Panagiota , Shao Yang , Bretin Ludovic , Siegler Maxime A. , Buda Francesco , Kros Alexander , Fan Jiangli , Peng Xiaojun , Sun Wen , Bonnet Sylvestre 
Published: May 2023

AbstractSelf-assembling molecular drugs combine the easy preparation typical of small-molecule chemotherapy and the tumour-targeting properties of drug–nanoparticle conjugates. However, they require a supramolecular interaction that survives the complex environment of a living animal. Here we report that the metallophilic interaction between cyclometalated palladium complexes generates supramolecular nanostructures in living mice that have a long circulation time (over 12 h) and efficient tumour accumulation rate (up to 10.2% of the injected dose per gram) in a skin melanoma tumour model. Green light activation leads to efficient tumour destruction due to the type I photodynamic effect generated by the self-assembled palladium complexes, as demonstrated in vitro by an up to 96-fold cytotoxicity increase upon irradiation. This work demonstrates that metallophilic interactions are well suited to generating stable supramolecular nanotherapeutics in vivo with exceptional tumour-targeting properties.
The spatial spillover effect of ICT development level on regional CO2 emissions
Authors: Su Jinqi , Wang Wenbo , Tang Shiyao 
Published: May 2023

AbstractInformation and communication technology plays an essential role in affecting CO2 emissions and promoting green and sustainable development. This paper empirically examines the effect of the level of urban ICT development on CO2 emissions using panel data for Chinese cities from 2010 to 2020. On this basis, a spatial Durbin model is used to analyze the spatial spillover effects of ICT development level affecting regional CO2 emissions, and its direct, indirect and overall effects are further analyzed. The conclusions of the study are as follows. (1) The CO2 emissions of Chinese cities are correlated by spatial distance and show high-high or low-low clustering characteristics. (2) ICT development can reduce CO2 emissions in the region and increase CO2 emissions in neighboring regions. This conclusion still holds after several robustness tests. And when the level of ICT development increases by 1 standard deviation, CO2 emissions are reduced by 64%. (3) The mechanism of action shows that ICT can influence regional CO2 emissions through its technological innovation effect and industrial upgrading effect. (4) The impact of ICT development on regional carbon emissions is characterized by significant heterogeneity depending on the city's geographical location and whether or not environmental information is publicly available.
Numerical analysis of Phase change material and graphene-based tunable refractive index sensor for infrared frequency spectrum
Authors: Aliqab Khaled , Dave Kavan , Sorathiya Vishal , Alsharari Meshari , Armghan Ammar 
Published: May 2023

AbstractHere, we present the findings of parametric analysis into a phase transition material Ge2Sb2Te5(GST)-based, graphene-based, with a wide dynamic range in the infrared and visible electromagnetic spectrum. The suggested structure is studied in multi-layered configurations, built up with layers of GST, graphene, silicon, and silver materials. These multilayer structures' reflectance behavior has been described for refractive indices between 1.3 and 2.5. The complete design is simulated using a computational process called the finite element method. Additionally, we have investigated the impact of material heights on the structure's performance in general. We have presented several resonating tracing curves in polynomial equations to determine the sensing behavior across a specific wavelength range and refractive index values. The proposed design is also investigated at various inclined angles of incidence to ascertain its wide-angle stability. A computational study of the proposed structure can assist in the evolution of biosensors to identify a wide range of biomolecules, including malignant, hemoglobin urine, saliva-cortisol, and glucose.
Environmental, cost, and chemical hazards of using alternative green solvents for fullerene (C60) purification
Authors: Heidari Seyed M. , Lee Eunsang , Cecil Ben , Anctil Annick 
Published: May 2023

C60 is an energy-intensive nanomaterial used for various emerging technologies, such as perovskite solar cells, hydrogen storage, and cancer therapy; however, manufacturing environmental, cost, and chemical hazards must be mitigated before large-scale production.
Efficient implementation of low cost and secure framework with firmware updates
Authors: Ben Hlima Ines , Kacem Halim , Gharsallah Ali 
Published: May 2023

AbstractRecently, the Internet of things (IoT) has become extensively used in our daily lives. This technology offers a new vision of the future internet where devices are interconnected and can communicate together. A big number of these devices complicates the firmware update and makes it more expensive since each node must be updated locally. Nevertheless, there are many cases where devices cannot change their location to upgrade the firmware locally due to an unreachable location or dangerous place. Therefore, it is necessary to remotely update the firmware of devices. In this study, the authors propose an efficient implementation of a low cost and secure framework of upgrading the firmware employing the latter On‐The‐Air programming technique. The authors present a proof of concept for a ubiquitous system applying wireless programmer. Our design offers a remote broadcasting of image code without disturbing the main functionality of nodes. The authors validated the performance of our design on a real network based on STM32 micro‐controllers. The results showed the reduction of the network time‐off, enabling a continuous operation of the ecosystem.
Improved SRP algorithm and bidirectional heterogeneous LTE‐R authentication key
Authors: Chen Yong , Chang Ting , Liu Wen 
Published: May 2023

AbstractDue to the problems that International Mobile Subscriber Identity is not encrypted during transmission, key disclosure, and high authentication overhead in Evolved Packet System‐Authentication and Key Agreement, the next generation of high‐speed railway Long‐Term Evolution for Railway train ground authentication protocol, this paper describes the improved Secure Remote Password algorithm and two‐way heterogeneous Long‐Term Evolution for Railway authentication key agreement scheme. First, the improved Secure Remote Password algorithm is used to encrypt the message transmission between User Equipment and Mobility Management Entity, solving the problem of International Mobile Subscriber Identity being not encrypted during transmission. Then, a two‐way heterogeneous digital signature method of Public Key Infrastructure and Identity‐Based Cryptosystem is proposed to authenticate and negotiate with the Mobility Management Entity and Home Subscriber Server, which improves the security of the root key and can effectively prevent man in the middle, replay and other attacks. Finally, in the research results, the random oracle model is used to verify, and the results show that our method is superior to the comparison method in security and authentication cost, and can meet the Long‐Term Evolution for Railway communication requirements.
Model predictive control for DAB under extended‐phase‐shift considering components uncertainty
Authors: Fu Yongsheng , Jing Zhengting , Ren Hai‐Peng 
Published: May 2023

AbstractFor the dual active bridge (DAB) DC‐DC converters, parameter uncertainty (circuit parameters, input and/or load perturbations) affect their performance, such as the dynamic performance and backflow power. Here, to deal with the uncertainties, a robust model predictive control (RMPC) for the DAB DC‐DC converter under extended‐phase‐shift (EPS) control is proposed to improve dynamic performance and reduce the backflow power of the DAB for the first time. First, a cost function consisting of backflow power and the output voltage is established. Second, considering the uncertainty of the circuit parameters, a robust term is added to the prediction model to increase the robustness. Finally, the effectiveness and superiority of the proposed method are verified by experiments and comparisons with existing methods. The proposed RMPC method shows superior performance in the sense of improved dynamic performance and reduced backflow power.
Power of wavelets in analyses of transit and phase curves in the presence of stellar variability and instrumental noise
Authors: Kálmán Sz. , Szabó Gy. M. , Csizmadia Sz. 
Published: May 2023

Context. Correlated noise in exoplanet light curves, such as noise from stellar activity, convection noise, and instrumental noise, distorts the exoplanet transit light curves and leads to biases in the best-fit transit parameters. An optimal fitting algorithm can provide stability against the presence of correlated noises and lead to statistically consistent results, namely, the actual biases are usually within the error interval. This is not automatically satisfied by most of the algorithms in everyday use and the testing of the algorithms is necessary.
Aims. In this paper, we describe a bootstrapping-like test to handle with the general case and we apply it to the wavelet-based Transit and Light Curve Modeller (TLCM) algorithm, testing it for the stability against the correlated noise. We compare and contrast the results with regard to the FITSH algorithm, which is based on an assumption of white noise.
Methods. We simulated transit light curves with previously known parameters in the presence of a correlated noise model generated by an Autoregressive Integrated Moving Average (ARIMA) process. Then we solved the simulated observations and examined the resulting parameters and error intervals.
Results. We have found that the assumption of FITSH, namely, that only white noise is present, has led to inconsistencies in the results: the distribution of best-fit parameters is then broader than the determined error intervals by a factor of 3–6. On the other hand, the wavelet-based TLCM algorithm handles the correlated noise properly, leading to both properly determined parameter and error intervals that are perfectly consistent with the actual biases.
Tradition und Innovation – Zwerge auf den Schultern von
Riesen
Authors: Gregor Bein 
Published: May 2023

Sehr geehrte Kollegin,
Sehr geehrter Kollege,bei der redaktionellen Durchsicht eines Beitrags aus diesem Heft ist uns aufgefallen,
dass die Nomenklatur für die Benennung der ABO-Blutgruppenmerkmale nicht
einheitlich verwendet wird. In Deutschland wird die Blutgruppe O mit
„null“ oder 0 bezeichnet. International werden die Blutgruppen im
ABO-System mit den Buchstaben A, B und O bezeichnet, entsprechend der Nomenklatur
der International Society of Blood Transfusion (ISBT).
Maternales Anti-D führt zu einer verzögerten
Hämolyse bei einem Neugeborenen
Authors: Hammer Stefanie , Uzun Günalp , Bakchoul Tamam 
Published: May 2023

ZusammenfasssungMütterliche Antikörper, welche sich gegen fetale
erythrozytäre Antigene richten, können eine Hämolytische
Erkrankung des Fetus oder Neugeborenen (HDFN) verursachen. In schweren
Fällen ist die HDFN mit hoher perinataler Mortalität und
Langzeitdefiziten assoziiert. Maternale Antikörper werden diaplazentar
übertragen, sodass diese bereits intrauterin zur Hämolyse
führen. Vereinzelt treten verzögerte Hämolysen des
Neugeborenen auf.
Der Zusammenhang von gesundheitskritischen Arbeitsbelastungen und
somatischen Symptomen bei frühpädagogischen Fachkräften
in der Kindertagesbetreuung während der
COVID-19-Pandemie
Authors: Gritzka Susan , Angerer Peter , Erschens Rebecca , Diebig Mathias 
Published: May 2023

ZusammenfassungDie COVID-19-Pandemie veränderte den Arbeitsalltag von Arbeitnehmenden
weltweit. Insbesondere frühpädagogische Fachkräfte in
der Kindertagesbetreuung erlebten aufgrund von Mehrbelastung am Arbeitsplatz ein
potentiell erhöhtes Erkrankungsrisiko für die individuelle
Gesundheit. Ziel dieser Querschnittsstudie war es, aktuelle Prävalenzen
von psychosozialem Arbeitsstress in Form von Gratifikationskrisen (Effort-Reward
Imbalance, ERI), Verausgabungsbereitschaft (Overcommitment) sowie somatischen
Symptomen und deren Assoziation während der COVID-19-Pandemie zu
erheben. Frühpädagogische Fachkräfte aus
Nordrhein-Westfalen (N=1009) nahmen zwischen Juni 2020 und Mai 2021 an
der Fragebogenstudie teil. Zur Beurteilung des Arbeitsstresses wurde der
Effort-Reward Imbalance Fragebogen eingesetzt (16 Items umfassende Version) und
zur Einschätzung somatischer Symptome der Gesundheitsfragebogen
für Patienten Modul „Somatische Symptomschwere“
(PHQ-15). Eine multiple logistische Regression überprüfte die
Assoziation zwischen Arbeitsstress und Ge-sundheit. Bei 72,3% der
Befragten wurde eine Gratifikationskrise festgestellt. Insgesamt zeigten
25,0% eine hoch ausgeprägte Verausgabungsbereitschaft
(Overcommitment). Die Gesamtprävalenz von somatischen Beschwerden auf
einem mittleren bis hohen Niveau lag bei 45,2%. Eine Gratifikationskrise
und eine hohe Verausgabungsbereitschaft vergrößerten das
Chancenverhältnis einer starken Symptompräsenz um den Faktor
4,12 bzw. 5,20. Diese Studie verdeutlicht die häufigen
Gratifikationskrisen, die hohe Verausgabungsbereitschaft und die
überdurchschnittlich hohe Prävalenz somatischer Beschwerden bei
frühpädagogischen Fachkräften während der
COVID-19-Pandemie. Angesichts dieser hohen Prävalenzen und deren
Zusammenhänge besteht weiterhin starker Handlungs- und Forschungsbedarf,
den arbeitsbezogenen Stress bei dieser Berufsgruppe zu reduzieren sowie die
Persistenz von sowie den Umgang mit somatischen Symptomen zu untersuchen, um
langfristig Präventionsmaßnahmen zu entwickeln.
Prediction of Preterm Birth with the Uterocervical Angle in Singleton Pregnancies Treated with a Cervical Pessary
Authors: Kyvernitakis Ioannis , von Gehren Friederike , Malan Marcel , Baschat Ahmet , Maul Holger , Osinski Maciej 
Published: May 2023

Abstract
Background Cervical pessaries are an established therapy option for patients at risk for spontaneous preterm birth (sPTB). The uterocervical angle (UCA) remains a promising sPTB predictor. However, its clinical significance has yet to be described in patients treated with a pessary.
Methods This study analyzed data of patients treated with a pessary because of cervical shortening in singleton pregnancies. The patients were divided into 2 groups according to transvaginal ultrasound findings: the funneling group (n = 68) and the no-funneling group (n = 42). Moreover, we analyzed patients within these prespecified groups according to the UCA < 95° and ≥ 95°.
Results Delivery occurred significantly earlier in patients treated with a pessary and with a high UCA ≥ 95°(p = 0.006). The median gestational age at delivery in patients treated with a pessary and with no funneling and a UCA < 95° vs. ≥ 95° were 39.00 and 36.14 weeks, respectively (p = 0.005). In cases with funneling and a UCA < 95° vs. ≥ 95° the mean gestational age at delivery was 38.14 and 38.07 weeks respectively (p=1,00). There was a significant negative linear correlation between UCA and the gestational age at delivery in all patients (p = 0.04), which was even profound in the group without funneling (p = 0.0002). However, we found no significant correlation between cervical length and gestational age at delivery in all patients (p = 0.42) as well as in the group without funneling (p = 0.28).
Conclusion In spite of pessary treatment, patients with UCA ≥ 95° presented with a higher risk of sPTB compared to patients with UCA < 95°. This suggests that the UCA seems to be a better predictor of sPTB than the cervical length in patients receiving pessary treatment.
Initial Psychometric Evaluation of the Portuguese Version of the Canine Orthopedic Index
Authors: Alves João C. 
Published: May 2023

Abstract
Objective The aim of this study was to perform the initial psychometric evaluation of the Portuguese version of the Canine Orthopaedic Index (COI).
Study Design In a prospective, randomized study, a group of 50 police working dogs with bilateral hip osteoarthritis was assessed. A copy of the translated Portuguese version of the COI was completed by canine handlers, native Portuguese speakers. This result was compared with that of 50 sound dogs. Construct validity was determined by comparing sound dogs and dogs with osteoarthritis scores with the Mann–Whitney test. Additionally, the Kaiser–Meyer–Olin measure of sampling adequacy, eigenvalue, and scree-plot analysis were performed. Internal consistency was tested with Cronbach's α.
Results A significant difference was observed between osteoarthritis and sound dogs in all dimensions of the COI (p < 0.01 for all), indicating construct validity. Two factors accounted for 87.8% of the total variance. Cronbach's α was 0.98, with a high interitem correlation, accounting for strong internal consistency.
Conclusion We presented criterion and construct validity of the Portuguese version of the COI. It is a step in providing clinicians with a validated and accessible tool to evaluate orthopaedic patients. Further studies are required.
State of the Evidence for Preservation Rhinoplasty: A Systematic Review
Authors: DeSisto Nicole G. , Okland Tyler S. , Patel Priyesh N. , Most Sam P. 
Published: May 2023

AbstractPreservation rhinoplasty encompasses a number of techniques that minimize disruption of the native cartilaginous and soft tissue nasal architecture. These techniques have gained popularity resulting in an increase in publications relevant to preservation rhinoplasty. However, many studies that present patient outcomes are of low-level evidence and do not incorporate validated patient-reported outcome measures. While these studies do consistently report positive outcomes, there are few high-level comparative studies that support the theoretical benefits of preservation relative to structural rhinoplasty. As contemporary preservation rhinoplasty techniques will continue to evolve and become incorporated into clinical practice, there will be the need for parallel emphasis on robust clinical studies to delineate the value of these methods.
Late-Onset Sepsis in Very Low Birth Weight Premature Infants: A 10-Year Review of a Brazilian Tertiary University Hospital—the Challenge Remains
Authors: Gerios Ludmila , Rodrigues Victor H. B. , Corrente José E. , Lyra João C. , Rugolo Ligia M. S. S. , Bentlin Maria R. 
Published: May 2023

Objectives This study aimed to assess the incidence of late-onset sepsis (LOS), associated risk factors, and short-term prognosis in very low birth weight (VLBW) infants in a 10-year period.
Study Design A cohort study was conducted with 752 VLBW preterm infants—23 to 33 gestational weeks and 400 to 1,500 g birth weight—admitted to a neonatal intensive care unit from 2008 to 2017 and who survived over 72 hours. LOS was defined as clinical and laboratory signs of infection, whether or not confirmed by blood culture. VLBW infants were divided into groups and compared: no LOS versus proven LOS versus clinical LOS. Study variables included maternal, birth, and neonatal data, morbidities, procedures, etiological agents, and outcome—death, bronchopulmonary dysplasia (BPD), severe intraventricular hemorrhage, and retinopathy of prematurity (ROP). Analysis of variance with multiple Tukey's or Wald's comparison with gamma distribution, and stepwise multiple logistic regression model, adjusted for year, and gestational age, were used for statistical analysis.
Results LOS incidence was 39% (proven LOS: 29%; clinical LOS: 10%). Septic VLBW infants showed higher mortality (proven LOS: 23.2%; clinical LOS: 41.9%) compared with no LOS (8.9%). Coagulase-negative staphylococci (56%), Gram-negative (26%), and fungi (8%) were the most frequent etiological agents. In comparing the groups, septic VLBW infants had lower gestational age and birth weight, presented more morbidities, and underwent more invasive procedures. The risk factors for proven and clinical LOS were days of mechanical ventilation and parenteral nutrition. LOS was associated with increased risk of death, BPD, and ROP.
Conclusion LOS showed high incidence and mortality, often caused by Gram-positive bacteria. Care interventions were the main risk factors associated. LOS had a major negative impact on short-term prognosis in VLBW infants. LOS reduction strategies are necessary and urgent.
Key Points