bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and dry wind tunnel test of progressive flexible variable bending wing
Authors: Xu X. D. , Chen G. G. , Li S. , Lv T. G. 
Published: July 2023

AbstractThe deformable wing structure can change its aerodynamic shape according to the change of flight mission and flight environment, so as to obtain better lift-drag, stability and control characteristics, which is considered as one of the future research directions of aviation technology. Considering the current technology maturity and reliability, a gradient corrugated fin is designed to realise the bending deformation of the wing. The structure of the skin is optimised to keep the skin smooth during deformation. In addition, a progressive push and pull rod is proposed to drive the wing deformation, and the fluid-structure interaction simulation is carried out for the wing deformation. At the same time, the changes of wing aerodynamic characteristics under different angles of leading and trailing edges and different push rod action schemes are analysed. Finally, a dry wind tunnel simulation test of the designed progressive flexible variable bending wing is carried out. The results of fluid-structure interaction simulation and dry wind tunnel test show that the progressive flexible variable bending wing proposed in this paper has a simple and reliable structure and remarkable deformation effect. It has advantages in increasing lift and reducing drag, ensuring high lift-drag ratio and providing wing trim moment. The deformable wing dry wind tunnel test platform designed by this method is structurally reliable, easy to operate, and can accurately reflect the influence of wing deformation on its aerodynamic force, which provides a verification means for the development of the design method and the design of practical aircraft in the future.
Reinsurance games with variance-premium reinsurers: from tree to chain
Authors: Cao Jingyi , Li Dongchen , Young Virginia R. , Zou Bin 
Published: July 2023

AbstractThis paper studies dynamic reinsurance contracting and competition problems under model ambiguity in a reinsurance market with one primary insurer and n reinsurers, who apply the variance premium principle and who are distinguished by their levels of ambiguity aversion. The insurer negotiates reinsurance policies with all reinsurers simultaneously, which leads to a reinsurance tree structure with full competition among the reinsurers. We model the reinsurance contracting problems between the insurer and reinsurers by Stackelberg differential games and the competition among the reinsurers by a non-cooperative Nash game. We derive equilibrium strategies in semi-closed form for all the companies, whose objective is to maximize their expected surpluses penalized by a squared-error divergence term that measures their ambiguity. We find that, in equilibrium, the insurer purchases a positive amount of proportional reinsurance from each reinsurer. We further show that the insurer always prefers the tree structure to the chain structure, in which the risk of the insurer is shared sequentially among all reinsurers.
Risk factors for predicting extended-spectrum β-lactamase-producing Enterobacterales (ESBLE) infections in non-urinary isolates
Authors: Burgoon Rachel , Hamby Aaron , Weeda Erin , Raux Brian R. , Hornback Krutika M. 
Published: July 2023

Abstract

Background:
With increases in antimicrobial resistance, it is crucial that patients receive appropriate antimicrobial therapy in a timely manner. Advancements in rapid diagnostics offer the ability to identify resistant organisms quickly. However, this technology is not always accessible and relies on correct specimen collection. While awaiting new microbiology methods, it may be beneficial to identify risk factors associated with common types of resistance. Specifically, extended-spectrum β-lactamase-producing Enterobacterales (ESBLE) are a rising threat globally.

Objective:
The primary objective of this retrospective case–control analysis was to identify factors associated with non-urinary ESBLE versus non-ESBLE infections.

Design/Methods:
Patient cultures were randomly selected based on type of culture (blood, bacterial, or exudate) and organism (E. coli, K. pneumoniae, or K. oxytoca) to provide a 1:1 ratio of ESBLE to non-ESBLE infections. Baseline demographics and potential risk factors (malignancy, cirrhosis, acute kidney injury (AKI), and diabetes) were collected for each patient encounter.

Results:
In the univariate analysis, risk factors that achieved a significant difference included cirrhosis, AKI, presence of urinary catheter, presence of center venous catheter, history of an ESBLE infection, hospital-acquired infection, and recent fluoroquinolone, cephalosporin, or beta-lactam use. The multivariate analysis showed that four factors were independently associated with an ESBLE infection: cirrhosis, urinary catheter, central venous catheter, and history of ESBLE. Having a history of an ESBLE had the highest adjusted odds ratio (aOR 12.49; 95% CI 4.71–33.15, P < .001) of the four factors.

Conclusions:
These results demonstrate that there may be benefit in incorporating select risk factors into clinical decision support tools to identify patients at highest risk of ESBLE infection.
Stereotypes, language, and race: Spaniards’ perception of Latin American immigrants
Authors: Chappell Whitney , Barnes Sonia 
Published: July 2023

AbstractThe present study explores how two symbolic boundaries—linguistic variety and race—intersect, influencing how Latin American immigrants are perceived in Spain. To this end, 217 Spaniards participated in an experiment in which they evaluated three men along a series of social properties, but they were presented with different combinations of linguistic variety (Argentinian, Colombian, or Spanish) and race (a White or Mestizo photograph). The results of mixed-effects regression models found that linguistic variety conditioned participants’ evaluations of status, occupational prestige, solidarity, and trustworthiness, and both variety and race conditioned evaluations of religiousness. We contend that linguistic features become associated with a specific group of people through rhematization (Gal, 2005; Irvine & Gal, 2000) and, by extension, ideologies link those people with stereotypical characteristics. We conclude that the “ideological twinning” (Rosa & Flores, 2017) of race and linguistic variety can enhance stereotypes toward immigrants and impact their experiences in the receiving country.
Praise the Gardeners, Dun the Hunters: Alaska Natives, Taxation, and Settler Colonialism
Authors: Zahnd Maximilien 
Published: July 2023

AbstractThis article explores the relationship between tax law and settler colonialism by looking at the ways in which taxes can be part of the “civilizing” process of Indigenous peoples. In 1921, the Territory of Alaska enacted a “license tax on the business of fur-farming, trapping and trading in pelts and skins of fur-bearing animals.” Since most trappers were Natives, the “fur tax” de facto targeted them. This article unpacks the sociocultural and political dimensions of the fur tax against the backdrop of Alaska’s settler colonial history. Despite what the Alaska attorney general claimed was its “strict” revenue-raising function, the tax was part of a much broader settler colonial agenda. That agenda sought to turn semi-nomadic, “uncivilized” Native hunters into spatially grounded, “civilized” farmers, gardeners, reindeer herders, or wage workers. Ultimately, I suggest, within many if not most settler colonial spaces political and sociocultural ideologies alter the initial revenue-raising function of taxes.
An ASP Framework for the Refinement of Authorization and Obligation Policies
Authors: INCLEZAN DANIELA 
Published: July 2023

AbstractThis paper introduces a framework for assisting policy authors in refining and improving their policies. In particular, we focus on authorization and obligation policies that can be encoded in Gelfond and Lobo’s
$\mathscr{AOPL}$
language for policy specification. We propose a framework that detects the statements that make a policy inconsistent, underspecified, or ambiguous with respect to an action being executed in a given state. We also give attention to issues that arise at the intersection of authorization and obligation policies, for instance when the policy requires an unauthorized action to be executed. The framework is encoded in Answer Set Programming.
Non-deterministic Approximation Operators: Ultimate Operators, Semi-equilibrium Semantics, and Aggregates
Authors: HEYNINCK JESSE , BOGAERTS BART 
Published: July 2023

AbstractApproximation fixpoint theory (AFT) is an abstract and general algebraic framework for studying the semantics of non-monotonic logics. In recent work, AFT was generalized to non-deterministic operators, that is, operators whose range are sets of elements rather than single elements. In this paper, we make three further contributions to non-deterministic AFT: (1) we define and study ultimate approximations of non-deterministic operators, (2) we give an algebraic formulation of the semi-equilibrium semantics by Amendola et al., and (3) we generalize the characterizations of disjunctive logic programs to disjunctive logic programs with aggregates.
Post-traumatic stress disorder among LGBTQ people: a systematic review and meta-analysis
Authors: Marchi Mattia , Travascio Antonio , Uberti Daniele , De Micheli Edoardo , Grenzi Pietro , Arcolin Elisa , Pingani Luca , Ferrari Silvia , Galeazzi Gian M. 
Published: July 2023

Abstract

Aims
Lesbian, gay, bisexual, transgender and queer people (LGBTQ) are at increased risk of traumatization. This systematic review aimed to summarize data regarding the risk of post-traumatic stress disorder (PTSD) for LGBTQ people and their subgroups.

Methods
Medline, Scopus, PsycINFO and EMBASE were searched until September 2022. Studies reporting a comparative estimation of PTSD among LGBTQ population and the general population (i.e., heterosexual/cisgender), without restrictions on participants’ age and setting for the enrolment, were identified. Meta-analyses were based on odds ratio (OR and 95% confidence intervals [CI]), estimated through inverse variance models with random effects.

Results
The review process led to the selection of 27 studies, involving a total of 31,903 LGBTQ people and 273,842 controls, which were included in the quantitative synthesis. Overall, LGBTQ people showed an increased risk of PTSD (OR: 2.20 [95% CI: 1.85; 2.60]), although there was evidence of marked heterogeneity in the estimate (I2 = 91%). Among LGBTQ subgroups, transgender people showed the highest risk of PTSD (OR: 2.52 [95% CI: 2.22; 2.87]) followed by bisexual people (OR: 2.44 [95% CI: 1.05; 5.66]), although these comparisons are limited by the lack of data for other sexual and gender minorities, such as intersex people. Interestingly, the risk of PTSD for bisexual people was confirmed also considering lesbian and gay as control group (OR: 1.44 [95% CI: 1.07; 1.93]). The quality of the evidence was low.

Conclusions
LGBTQ people are at higher risk of PTSD compared with their cisgender/heterosexual peers. This evidence may contribute to the public awareness on LGBTQ mental health needs and suggest supportive strategies as well as preventive interventions (e.g., supportive programs, counselling, and destigmatizing efforts) as parts of a tailored health-care planning aimed to reduce psychiatric morbidity in this at-risk population.
A Path to Research in Space Physics
Authors: McPherron R. L. 
Published: July 2023

AbstractSuccess in research depends on multiple factors, many outside the control of an individual. I was born during the Great Depression, began school during World War II, and was 12 years old before I lived in a house with running water, electricity, or a telephone. In the second or third grade, I decided to be a scientist, and all my activities after that contributed to this goal. In this paper, I summarize a few early events and focus on my activities in the Ph.D. Physics program at Berkeley, and my first few years after graduation. Being well‐prepared, hardworking, self‐sufficient, and blessed by fortunate circumstances is important. However, good fortune is insufficient if you are not proactive. Once success seems to be within grasp, it is important to consistently promote your ideas and communicate them in lectures and publications. Space Physics research exploded the year I started my research providing abundant opportunities for discoveries. There were few competitors, and significant resources were available. I was fortunate to be educated at one of the first space research centers and find a permanent position at another. Circumstances have changed in the 60 years since I began research. The opportunities for quick discoveries and rapid recognition have moved away from my field of magnetospheric physics. New instruments, new methods of analysis, large amounts of data, and advanced modeling tools are needed to make incremental advances.
Simulation of a Dust‐And‐Rain Event Across the Red Sea Using WRF‐Chem
Authors: Parajuli Sagar P. , Stenchikov Georgiy L. , Ukhov Alexander , Morrison Hugh , Shevchenko Illia , Mostamandi Suleiman 
Published: July 2023

AbstractWe present simulations of a series of dust‐and‐rain events in July/August 2020 that caused significant loss of life and property over northeast Africa and the Red Sea coast using convection‐permitting Weather Research and Forecasting‐Chem simulations at 1.5 km horizontal grid spacing coupled with prognostic dust and aerosol scheme together with a double‐moment cloud microphysical scheme. The model generally captures the optical properties and vertical profiles of dust but has difficulty reproducing the seasonal dust plumes that originate over northeast Africa and reach the western Arabian Peninsula through the Tokar gap. Overlapping of synoptic events with local, diurnal‐scale, convective features caused continuous rainfall over the study domain in July/August 2020. The model well simulates the synoptically‐driven clouds over the ocean (∼4–8 km) and daytime deep convective clouds over the land but cannot reproduce cumulus clouds over the ocean advected from land, which leads to some biases in simulating peak rainfall rates. Although our simulations do not explicitly consider aerosol particles as ice nuclei, the model reproduces the cirrus clouds found at ∼10–15 km height during the study period. Simulations with a planetary boundary layer (PBL) scheme better represented the diurnal profile of surface temperature and winds, as well as the rainfall distribution, than without using a PBL scheme. Dust generally enhanced rainfall during the synoptic rain event through indirect effects but suppressed rainfall during sea‐breeze‐induced convective events through dust direct effects by weakening the sea‐breeze circulation.
Impact of Forbush Decreases and Geomagnetic Storms on the Atmospheric Ozone Profiles
Authors: Kilifarska Natalya , Peqini Klaudio 
Published: July 2023

AbstractThe sensitivity of atmospheric ozone to geomagnetic storms and reduced cosmic rays' (CRs) intensity (called Forbush decrease [FD]) has been noticed for many years. However, it is still unclear what the factors affecting ozone density are—whether these are the complex changes induced by geomagnetic storms in the upper atmosphere and ionosphere, or it is the severe reduction of CRs accessing Earth's lower atmosphere. Analyzing two strong geomagnetic storms, accompanied by FDs, and another FD occurred in geomagnetically quiet conditions, we conclude that observed ozone changes support the idea about the existence of an additional source of ozone in the lower stratosphere. The ion‐molecular reactions of catalytic ozone production are initiated by secondary ionization, produced by cosmic radiation at these levels. This conclusion is supported by the fact that the strongest ozone depletion beneath its maximum is found in regions with the severest reduction of CR flux. Moreover, the time delay of ozone response (∼2 days), is short enough to be attributed to changes in circulation. In addition, we have examined the changes in the sea level pressure during the analyzed events and found out that the surface pressure follows dynamically the spatial pattern of the ozone changes, forced by the reduced amount of precipitating energetic particles in the atmosphere.
Deep learning identifies a T-cell exhaustion-dependent transcriptional signature for predicting clinical outcomes and response to immune checkpoint blockade
Authors: Zhang Zicheng , Chen Hongyan , Yan Dongxue , Chen Lu , Sun Jie , Zhou Meng 
Published: July 2023

AbstractImmune checkpoint blockade (ICB) therapies have brought unprecedented advances in cancer treatment, but responses are limited to a fraction of patients. Therefore, sustained and substantial efforts are required to advance clinical and translational investigation on managing patients receiving ICB. In this study, we investigated the dynamic changes in molecular profiles of T-cell exhaustion (TEX) during ICB treatment using single-cell and bulk transcriptome analysis, and demonstrated distinct exhaustion molecular profiles associated with ICB response. By applying an ensemble deep-learning computational framework, we identified an ICB-associated transcriptional signature consisting of 16 TEX-related genes, termed ITGs. Incorporating 16 ITGs into a machine-learning model called MLTIP achieved reliable predictive power for clinical ICB response with an average AUC of 0.778, and overall survival (pooled HR = 0.093, 95% CI, 0.031–0.28, P < 0.001) across multiple ICB-treated cohorts. Furthermore, the MLTIP consistently demonstrated superior predictive performance compared to other well-established markers and signatures, with an average increase in AUC of 21.5%. In summary, our results highlight the potential of this TEX-dependent transcriptional signature as a tool for precise patient stratification and personalized immunotherapy, with clinical translation in precision medicine.
BMI and well-being in people of East Asian and European ancestry: a Mendelian randomisation study
Authors: O’Loughlin Jessica , Casanova Francesco , Hughes Amanda , Fairhurst-Hunter Zammy , Li Liming , Chen Zhengming ,   China Kadoorie Biobank Collaborative Group, Bowden Jack , Watkins Ed , Freathy Rachel M. , Howe Laura D. , Walters Robin G. , Tyrrell Jessica 
Published: July 2023

AbstractPrevious studies have linked higher body mass index (BMI) to lower subjective well-being in adult European ancestry populations. However, our understanding of these relationships across different populations is limited. Here, we investigated the association between BMI and well-being in people of (a) East Asian and (b) European ancestry in the China Kadoorie Biobank (CKB) and UK Biobank (UKB), respectively. Mendelian randomisation (MR) methods were used to test the relationship between BMI with (a) health satisfaction and (b) life satisfaction. One-sample MR enabled us to test effects in men and women separately and to test the role of cultural contexts by stratifying our analyses by urban and rural home location in both China and the UK. Further, we implemented a control function method to test the linearity of the BMI-well-being relationship. We found evidence of different associations between BMI and well-being in individuals of East Asian versus European ancestry. For example, a genetically instrumented higher BMI tentatively associated with higher health satisfaction in people of East Asian ancestry, especially in females (ß: 0.041, 95% CI: 0.002, 0.081). In contrast, there was a robust inverse association between higher genetically instrumented BMI and health satisfaction in all European ancestry UKB participants (ß: −0.183, 95% CI: −0.200, −0.165, Pdifference < 1.00E−15). We also showed the importance of considering non-linear relationships in the MR framework by providing evidence of non-linear relationships between BMI and health and life satisfaction. Overall, our study suggests potential setting-specific causality in the relationship between BMI and subjective well-being, with robust differences observed between East Asians and Europeans when considering very similar outcomes. We highlight the importance of (a) considering potential non-linear relationships in causal analyses and (b) testing causal relationships in different populations, as the casual nature of relationships, especially relationships influenced by social processes, may be setting-specific.
Anticoagulant therapy and home blood pressure-associated risk for stroke/bleeding events in elderly patients with non-valvular atrial fibrillation: the sub-cohort study of ANAFIE registry
Authors: Kario Kazuomi , Hasebe Naoyuki , Okumura Ken , Yamashita Takeshi , Akao Masaharu , Atarashi Hirotsugu , Ikeda Takanori , Koretsune Yukihiro , Shimizu Wataru , Suzuki Shinya , Tsutsui Hiroyuki , Toyoda Kazunori , Hirayama Atsushi , Yasaka Masahiro , Yamaguchi Takenori , Teramukai Satoshi , Kimura Tetsuya , Morishima Yoshiyuki , Takita Atsushi , Inoue Hiroshi 
Published: July 2023

AbstractThe benefits of direct oral anticoagulants (DOACs) and warfarin in elderly Japanese patients with non-valvular atrial fibrillation (NVAF) and high home systolic blood pressure (H-SBP) are unclear. This sub-cohort study of the ANAFIE Registry estimated the incidence of clinical outcomes in patients receiving anticoagulant therapy (warfarin and DOACs) stratified by H-SBP levels (<125 mmHg, ≥125–<135 mmHg, ≥135–<145 mmHg and ≥145 mmHg). Of the overall ANAFIE population, 4933 patients who underwent home blood pressure (H-BP) measurements were analyzed; 93% received OACs (DOACs: 3494, 70.8%; warfarin: 1092, 22.1%). In the warfarin group, at <125 mmHg and ≥145 mmHg, the respective incidence rates (per 100 person-years) were 1.91 and 5.89 for net cardiovascular outcome (a composite of stroke/systemic embolic events (SEE) and major bleeding), 1.31 and 3.39 for stroke/SEE, 0.59 and 3.91 for major bleeding, 0.59 and 3.43 for intracranial hemorrhage (ICH), and 4.01 and 6.24 for all-cause death. Corresponding incidence rates in the DOACs group were 1.64 and 2.65, 1.00 and 1.88, 0.78 and 1.69, 0.55 and 1.31, and 3.43 and 3.51. In warfarin-treated patients, the incidence rates of net cardiovascular outcome, stroke/SEE, major bleeding, and ICH were significantly increased at H-SBP ≥ 145 mmHg versus <125 mmHg. In the DOAC group, although there was no significant difference between H-SBP < 125 mmHg and ≥145 mmHg, the incidence rates of these events tended to increase at ≥145 mmHg. These results suggest that strict BP control guided by H-BP is required in elderly NVAF patients receiving anticoagulant therapy.
The role of vaccination and public awareness in forecasts of Mpox incidence in the United Kingdom
Authors: Brand Samuel P. C. , Cavallaro Massimo , Cumming Fergus , Turner Charlie , Florence Isaac , Blomquist Paula , Hilton Joe , Guzman-Rincon Laura M. , House Thomas , Nokes D. James , Keeling Matt J. 
Published: July 2023

AbstractBeginning in May 2022, Mpox virus spread rapidly in high-income countries through close human-to-human contact primarily amongst communities of gay, bisexual and men who have sex with men (GBMSM). Behavioural change arising from increased knowledge and health warnings may have reduced the rate of transmission and modified Vaccinia-based vaccination is likely to be an effective longer-term intervention. We investigate the UK epidemic presenting 26-week projections using a stochastic discrete-population transmission model which includes GBMSM status, rate of formation of new sexual partnerships, and clique partitioning of the population. The Mpox cases peaked in mid-July; our analysis is that the decline was due to decreased transmission rate per infected individual and infection-induced immunity among GBMSM, especially those with the highest rate of new partners. Vaccination did not cause Mpox incidence to turn over, however, we predict that a rebound in cases due to behaviour reversion was prevented by high-risk group-targeted vaccination.