bluuebunny/crossref_metadata_2025_split huggingface dataset:
El barroco maravilloso de Las malas: nuevas aproximaciones a la tradición desde la literatura del presente
Authors: Gamba Ana Marina 
Published: May 2023

En su novela Las malas (2019), la autora argentina Camila Sosa Villada propone una compleja inscripción en la tradición literaria latinoamericana, haciendo de esta el lugar de enunciación de una palabra transgresora y disidente. En este artículo pretendemos mostrar cómo este uso de la tradición configura el gesto crítico de la autora, el cual le permite problematizar los límites del lenguaje y su capacidad para “representar” al otro. En sus modalizaciones y actualizaciones críticas del barroco americano y lo real maravilloso, sostenemos, la novela articula un discurso sobre los marcos políticos-culturales de inteligibilidad contemporáneos que impiden el reconocimiento de las vidas trans en tanto duelables.
Less is More: Mitigate Spurious Correlations for Open-Domain Dialogue Response Generation Models by Causal Discovery
Authors: Feng Tao , Qu Lizhen , Haffari Gholamreza 
Published: May 2023

Abstract
In this paper, we conduct the first study on spurious correlations for open-domain response generation models based on a corpus CGDialog curated by ourselves. The current models indeed suffer from spurious correlations and have a tendency to generate irrelevant and generic responses. Inspired by causal discovery algorithms, we propose a novel model-agnostic method for training and inference using a conditional independence classifier. The classifier is trained by a constrained self-training method, coined ConSTrain, to overcome data sparsity. The experimental results based on both human and automatic evaluation show that our method significantly outperforms the competitive baselines in terms of relevance, informativeness, and fluency.
The Great Migration and Healthcare to Black America
Authors: Nakayama Don K. 
Published: May 2023

The Great Migration, the movement of 6,000,000 black Americans from the South to the great urban centers of the eastern seaboard, the industrial Midwest, and West Coast port cities from roughly 1915-1970, was one of the defining demographic events in American history. It dwarfed the 100,000 49ers who swarmed westward in search of gold, the incarceration of 110,000 Japanese to concentration camps in the American interior during World War II, and the 300,000 Okies who escaped the Dust Bowl to California. In the words of writer Isabel Wilkerson, “[It] swept a good portion of all the black people alive in the United States at the time into a river that carried them to all points north and west.” Blacks crammed into urban districts rife with crime and communicable disease, subjecting them to risks of death far higher than their proportion of the population. Without access to adequate inpatient hospital facilities, they received care in public hospitals run by hospital staffs that excluded black physicians from their membership and medical schools that refused admission to black students. The untenable health station of Black America was one of the leading causes of the civil rights movement of the 1950s and 1960s, activism that succeeded in integrating the hospitals and medical schools by federal acts passed in 1964 and 1965 that transformed American medicine.
Establishing an International Interdisciplinary Research Network in Craniofacial Microsomia: The CARE Program
Authors: Stock Nicola M. , Crerand Canice E. , Johns Alexis L. , McKinney Christy M. , Koudstaal Maarten J. , Drake Amelia F. , Heike Carrie L. 
Published: May 2023

Objective Craniofacial microsomia (CFM) is a broad clinical term used to describe a congenital condition most commonly involving the underdevelopment of the external ear, mandible, soft tissues, and facial nerve. Despite medical advances, understanding of the psychological health and healthcare experiences of individuals with CFM and their caregivers remains limited. This article describes a research program designed to address these knowledge gaps, and identify opportunities for psychosocial intervention and improved healthcare provision. Design The Craniofacial microsomia: Accelerating Research and Education (CARE) research program aims to: 1) Conduct up to 160 narrative interviews with individuals and caregivers to validate a conceptual framework; 2) Administer an online international survey of up to 800 individuals with CFM and caregivers to identify predictors of psychological distress; 3) Perform up to 60 semi-structured interviews with healthcare providers and advocacy leaders to examine the extent to which current healthcare provisions address identified patient needs; and 4) Establish a participant registry to build a longitudinal database and develop an international community. Results Teams in the USA and UK have been established, alongside an international, interdisciplinary Advisory Committee. Data analysis for Aim 1 is ongoing and informing the delivery of Aims 2-3. Aim 4 is also in development. A dedicated website serves as a recruitment tool, educational resource, and mechanism for engaging with the CFM community. Conclusions The CARE program provides a comprehensive approach to understanding the experiences of individuals with CFM and their caregivers. Challenges encountered and lessons learned are shared for the benefit of the community.
TRIM11 Posttranscriptionally Modulated by miR-5193 Facilitates Tumor Growth and Metastasis of Prostate Cancer
Authors: Pan Yue , Yu Hui , Lu Feng 
Published: May 2023

Objective Tripartite motif-containing protein 11 (TRIM11), an E3 ubiquitin ligase, possesses a pro-tumor property. Still, the detailed functions of TRIM11 remain not well characterized in prostate cancer. Methods PC-3 and DU145 prostate cancer cells were transfected with small interfering RNAs (siRNAs) or lentiviruses for TRIM11 deficiency or overexpression, and microRNA-5193 (miR-5193) mimics were utilized for overexpressing miR-5193. Proliferation, apoptosis, migration, and invasion were examined through CCK-8, colony formation, flow cytometry, wound healing, and transwell assays. MAP kinase-extracellular signal-regulated kinase (MEK1/2) and extracellular signal-regulated kinase (ERK)1/2 activities were detected via immunoblotting. Murine xenograft models were established. Interactions of TRIM11 with miR-5193 were demonstrated via dual luciferase reporter. Results TRIM11 deficiency or miR-5193 overexpression exerted antiprostate cancer effects through suppression of proliferation, migration, and invasion as well as enhancement of apoptosis in PC-3 and DU145 cells. The mechanisms by which TRIM11 deficiency or miR-5193 overexpression involved the inactivation of MEK1/2 and ERK1/2. miR-5193 downregulated TRIM11 expressions in prostate cancer cells, and their interactions were confirmed. Further, up-regulated miR-5193 weakened the effects of TRIM11 overexpression on enhancing proliferation, migration, invasion, and activity of MEK1/2 and ERK1/2 as well as alleviating apoptosis of prostate cancer cells. In murine xenograft models, TRIM11 upregulation facilitated tumor growth, which was alleviated by miR-5193 overexpression. Conclusion These findings described the oncogenic role of TRIM11 in prostate cancer biology, which was post-transcriptionally modulated by miR-5193.
HEALing Our Nation - Health Equity Achieved Through Lifestyle Medicine Capturing Highlights From the “HEALing Our Nation” Session at LM2023 and Outlining the Important Work of the HEAL Initiative
Authors: Davis Marsha-Gail , Shurney Dexter , Stone Terri , Bowman David 
Published: May 2023

Since the COVID-19 pandemic, health equity has been placed front and center in the conversations surrounding healthcare as well other fields. This conversation has also been occurring in the field of lifestyle medicine with an intentional focus on developing solutions at the intersection of lifestyle medicine and health equity. Initiated by a call to action by ACLM Past President Dexter Shurney at the 2019 Lifestyle Medicine conference, the HEAL Initiative was created with that intention, to address health disparities and advance health equity through lifestyle medicine. Since 2019, the HEAL initiative has grown considerably in its work and impact, creating solutions aligned with the AMA strategic planning recommendations as well developing projects that are examples of community engaged-lifestyle medicine. The work of the HEAL initiative culminated in a full circle moment at the 2023 Lifestyle Medicine Conference which featured an interview (facilitated by Dr. Dexter Shurney) with former US Surgeon General Dr. Jerome Adams and review of HEAL’s work over the past 3 years. This article will capture the key highlights of the HEALing our Nation opening session and the cumulative work of HEAL Initiative.
Iron deficiency anemia impacts disease progression and healthcare resource consumption in patients with inflammatory bowel disease: a real-world evidence study
Authors: Fiorino Gionata , Colombel Jean-Frederic , Katsanos Kostas , Mearin Fermín , Stein Jürgen , Andretta Margherita , Antonacci Stefania , Arenare Loredana , Citraro Rita , Dell’Orco Stefania , Degli Esposti Luca , Ramirez de Arellano Serna Antonio , Morin Neige , Koutroubakis Ioannis E. 
Published: May 2023

Background: Iron deficiency anemia (IDA) is a common extraintestinal manifestation of inflammatory bowel disease (IBD), affecting around one-third of patients. Objective: To compare IBD progression and healthcare resource utilization in patients with and without a co-diagnosis of IDA in a real-world setting. Design: A retrospective comparative study was conducted using Italian entities’ administrative databases, covering 9.3 million health-assisted individuals. Methods: Adult IBD patients diagnosed with ulcerative colitis and/or Crohn’s disease were enrolled between January 2010 and September 2017. Within 12 months from IBD diagnosis, IDA was identified by at least one prescription for iron and/or IDA hospitalization and/or blood transfusion (proxy of diagnosis). IBD population was divided according to the presence/absence of IDA. Given the nonrandom patients’ allocation, propensity score matching (PSM) was applied to abate potential unbalances between the groups. Before and after PSM, IBD progression (in terms of IBD-related hospitalizations and surgeries), and healthcare resource costs were assessed. Results: Overall, 13,475 IBD patients were included, with an average age at diagnosis of 49.9 years, and a 53.9% percentage of male gender. Before PSM, 1753 (13%) patients were IBD–IDA, and 11,722 (87%) were IBD–non-IDA. Post-PSM, 1753 IBD–IDA patients were matched with 3506 IBD–non-IDA. Before PSM, IBD progression was significantly higher in IBD–IDA (12.8%) than in IBD–non-IDA (6.5%) ( p < 0.001). After PSM, IBD progression and IBD-related hospitalizations were significantly ( p < 0.001) more frequent in IBD–IDA patients (12.8% and 12.0%, respectively) compared to IBD–non-IDA (8.7% and 7.7%). Consistently, healthcare expenditures resulted significantly higher among IDA patients ( p < 0.001), with an overall mean annual cost of €5317 compared to €2798 for patients without IDA. These results were confirmed after PSM matching, as the mean annual total cost/patient in IBD–IDA versus IBD–non-IDA were €3693 and €3046, respectively ( p < 0.001). Conclusion: In a real-life setting, IDA co-diagnosis in IBD patients was associated with disease progression and higher related economic burden.
Artificial intelligence in endoscopic ultrasonography: risk stratification of gastric gastrointestinal stromal tumors
Authors: Lu Yi , Chen Lu , Wu Jiachuan , Er Limian , Shi Huihui , Cheng Weihui , Chen Ke , Liu Yuan , Qiu Bingfeng , Xu Qiancheng , Feng Yue , Tang Nan , Wan Fuchuan , Sun Jiachen , Zhi Min 
Published: May 2023

Background: Previous studies have identified useful endoscopic ultrasonography (EUS) features to predict the malignant potential of gastrointestinal stromal tumors (GISTs). However, the results of the studies were not consistent. Artificial intelligence (AI) has shown promising results in medicine. Objectives: We aimed to build a risk stratification EUS-AI model to predict the malignancy potential of GISTs. Design: This was a retrospective study with external validation. Methods: We developed two models using EUS images from two hospitals to predict the GIST risk category. Model 1 was the four-category risk EUS-AI model, and Model 2 was the two-category risk EUS-AI model. The diagnostic performance of the models was validated with external cohorts. Results: A total of 1320 images (880 were very low-risk, 269 were low-risk, 68 were intermediate-risk, and 103 were high-risk) were finally chosen for building the models and test sets, and a total of 656 images (211 were very low-risk, 266 were low-risk, 88 were intermediate-risk, and 91 were high-risk) were chosen for external validation. The overall accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for the four-category risk EUS-AI model in the external validation sets by tumor were 74.50%, 55.00%, 79.05%, 53.49%, and 81.63%, respectively. The accuracy, sensitivity, specificity, PPV, and NPV for the two-category risk EUS-AI model for the prediction of very low-risk GISTs in the external validation sets by tumor were 86.25%, 94.44%, 79.55%, 79.07%, and 94.59%, respectively. Conclusion: We developed a EUS-AI model for the risk stratification of GISTs with promising results, which may complement current clinical practice in the management of GISTs. Registration: The study has been registered in the Chinese Clinical Trial Registry (No. ChiCTR2100051191).
Toward Oral Thanatomicrobiology—An Overview of the Forensic Implications of Oral Microflora
Authors: Nilendu Debesh 
Published: May 2023

Introduction:The oral cavity is home to numerous microorganisms including bacteria, fungi, and viruses which together form the oral microflora. It is the second most diverse microbial site in the human body after the gastrointestinal tract. Microbial degradation is a common phenomenon that occurs after death, with the early and advanced stages of decomposition being closely associated with oral microbial activity.Methods:This article reviews the current state of knowledge on the role of the oral microflora in postmortem events, and highlights the growing importance of terms such as forensic microbiology and thanatomicrobiome. This article also discusses next-generation sequencing, metagenomic sequencing studies, and RNA sequencing to study the oral thanatomicrobiome and epinecrotic communities in forensic oral genetics.Results:The indigenous microorganisms in the oral cavity are among the first to respond to the process of decomposition. DNA/RNA sequencing is a relatively simple, precise, and cost-effective method to estimate biological diversity during various stages of postmortem decomposition. The field of thanatomicrobiology is rapidly evolving into a key area in forensic research.Conclusion:This article briefly narrates oral microflora and its implications in forensic odontology. The role of microbial activity in postmortem events is gaining importance in forensic research, and further studies are needed to fully understand the potential applications of advanced technology in the study of the oral thanatomicrobiome.
A systematic review and meta-analysis protocol on knowledge of obstetric danger signs and associated factors among women in Africa
Authors: Moloro Abdulkerim Hassen , Waritu Tejo Ushu , Haso Mustefa Kasim , Ibrahim Roda Mehadi 
Published: May 2023

Objective: This systematic review and meta-analysis will investigate the pooled knowledge level of obstetric danger signs and related factors among African women. Design: Systematic review and meta-analysis incorporating cross-sectional, case–control, and cohort study designs. Methods: Studies published with full texts in English language from the beginning to the present will be searched in the PubMed/MEDLINE, Cumulative Index to Nursing & Allied Health Literature, African Journals Online, and Google Scholar databases. Checklists from the Joanna Briggs Institute will be used to assess the quality of the studies’ methodology. Data extraction, critical appraisal, and screening of all retrieved articles will be conducted by two independent reviewers. Statistical analysis will be performed using the STATA-14 and Review Manager 5.3 (RevMan 5.3) software packages. A random effect will be employed to demonstrate pooled estimates of knowledge among women. For determinants of knowledge, an effect size with a 95% confidence interval will be analyzed. Protocol Registration: This systematic review and meta-analysis protocol was registered in PROSPERO with the registration ID and link as follows: CRD42022379085; CRD register@york.ac.uk https://www.york.ac.uk/inst/crd Discussion: Women who are more knowledgeable about obstetric danger signs are more likely to seek emergency care on time, closely attend antenatal care, and be better prepared for labor and any complications, which reduces both maternal and child mortality. This analysis will provide evidence of the pooled prevalence of knowledge of obstetric danger signs among African women, as well as contributing factors.
Survey on Changes in Neurophysiotherapy at a Hospital/Clinic and Home-Based Settings in India During COVID-19 Pandemic
Authors: Bhanot Komal , Gandhi Dorcas B. C. , Makkar Mridul , Khatter Himani , Pandian Jeyaraj Durai 
Published: May 2023

Background COVID-19 exposed the weakened healthcare sector and burdened the economic sector. Patients with neurological diseases require physical rehabilitation from the acute to chronic phase irrespective of their COVID positive status. Objective To evaluate the qualitative and quantitative changes in neurological physiotherapy at hospital/clinic and home-based settings in India during the COVID-19 pandemic. Methodology Using an online survey, a cross-sectional observational study was implemented among physiotherapists in India who treated neurological patients amidst the pandemic at hospital/clinic and for home-based settings using an online survey. Convenience sampling was used for recruiting participants in the study. Results and Conclusion Most of the physiotherapists, whether working in hospitals or in patients’ homes, indicated a decline in the number of referrals and therapy sessions given to their patients. Both groups resorted to the use of various forms of telerehabilitation in delivering therapy. Even though there is evidence supporting the necessity of physiotherapy for respiratory care, most of the respondents did not put it into practice. No protocols/guidelines for therapy delivery were implemented or used by our sample of respondents. This paper highlights the needs under 3 main categories: (a) development and implementation of contextualized clinical-practice-guidelines and clinical-monitoring systems for neurological physiotherapy, (b) incorporating respiratory physiotherapy sessions supported by research to treat neurological cases in such pandemics, and (c) to modify policies both at public and private domains ensuring incorporation and implementation of physiotherapy for neurological conditions, and to raise campaigns that educate the public on the significance of receiving uninterrupted physiotherapy, even during similar pandemics.
Demonstration of MOCVD-grown Ga2O3 power MOSFETs on sapphire with in-situ Si-doped by tetraethyl orthosilicate (TEOS)
Authors: Ngo Sao Thien , Lu Chan-Hung , Tarntair Fu-Gow , Chung Sheng-Ti , Wu Tian-Li , Horng Ray-Hua 
Published: May 2023

AbstractIn this work, we demonstrated Ga2O3-based power MOSFETs grown on c-plane sapphire substrates using in-situ TEOS doping for the first time. The β-Ga2O3:Si epitaxial layers were formed by the metalorganic chemical vapor deposition (MOCVD) with a TEOS as a dopant source. The depletion-mode Ga2O3 power MOSFETs are fabricated and characterized, showing the increase of the current, transconductance, and breakdown voltage at 150 °C. In addition, the sample with the TEOS flow rate of 20 sccm exhibited a breakdown voltage of more than 400 V at RT and 150 °C, indicating that the in-situ Si doping by TEOS in MOCVD is a promising method for Ga2O3 power MOSFETs.
Chronic oral exposure to Amistar fungicide does not significantly affect colour discrimination but may impact memory retention in bumblebees
Authors: Kaila Lotta , Despains Léo , Nyckees Danae , Toivonen Marjaana , Jalli Marja , Loukola Olli J. 
Published: May 2023

Abstract
Background
Intensive agriculture, including pesticides, is one of the many reasons for pollinator decline. The EU legislation on plant protection products (hereon pesticides) demands that the risks of active substances and their use in pesticide products are assessed for bees. However, the risk assessment is not always sufficient as shown, for example, in the case of the fungicide Amistar. The fungicide has been shown to cause lethal and sublethal effects on bumblebees at levels that, according to the EU risk assessment, do not require risk mitigation measures to protect bees. In order to understand the effects of chronic Amistar exposure on bumblebees, we studied whether 5 days of oral exposure to 0.015 µl Amistar (3.75 µg azoxystrobin/day) impairs bumblebees’ learning and memory performance in the 10-colour discrimination task.

Results
Chronic Amistar treatment did not impair the learning of the bees, but a statistically non-significant negative trend was observed in memory retention between the final learning bout and the subsequent memory test.

Conclusions
The results of our study suggest that chronic sublethal exposure to Amistar fungicide did not significantly impair the learning ability of bumblebees. However, there was a trend towards impaired memory retention, although this was not statistically significant. These findings provide further support for the hypothesis that Amistar may have a negative effect on bee cognitive performance. It is important to continue studying the effects of widely used pesticides on pollinators, as their decline is a complex issue with multiple contributing factors. Understanding the effects of different pesticide residue levels on bumblebees can inform policymakers in making more sustainable pesticide legislation and help protect pollinators.
Comparative genetic and epigenetic of the Sphagneticola trilobata (L.) Pruski from different regions in China
Authors: Xiao Yusha , Chen Xiuqing , Yin Yuhan , Zheng Jiening , Yi Huixian , Song Liying 
Published: May 2023

AbstractBackgroundSphagneticola trilobata(L.) Pruski is a prevalent and widely distributed invasive plant in South China. To investigate the molecular mechanisms underlying its rapid adaptation, we employed DNA methylation-sensitive amplified polymorphism (MSAP) and simple sequence repeat (SSR) analysis to study 60S. trilobataindividuals collected from Fuzhou (FZ), Haikou (HK), Jinghong (JH) and Guangzhou (GZ).ResultsIn this study, we computed the Shannon diversity index (I) of SSR and MSAP as 0.354 and 0.303, respectively. The UPGMA phylogenetic tree and PCoA analyses showed that MSAP had a better discriminatory power to distinguish populations from different regions. Notably, the GZ population was found to be the most distinct from the other three populations. Moreover, Mantel analysis revealed a significantly higher correlation between epigenetic distance and geographic distance as compared to genetic distance and geographic distance. Consequently, the correlation between epigenetic distance and geographic distance observed to be markedly stronger than that between genetic distance and geographical distance on Mantel analysis.ConclusionsTheS. trilobatapopulations in various regions displayed a high of complementary genetic and epigenetic diversity, which was a key feature contributing to their rapid invasion. Interestingly, the correlation between epigenetics and geographical distance was significantly stronger than that observed for genetics and geographical distance. These findings indicated that the epigenetic mechanism ofS. trilobarexhibited high plasticity, leading to significant differences in methylation pattern across different populations.