bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compassion Fatigue and Ethical Attitudes in Nursing Care in Intensive Care Nurses During the COVID-19 Pandemic
Authors: Gurdap Zuleyha , Cengiz Zeliha 
Published: March 2023

Background:
Intensive care unit (ICU) nurses faced an increased risk of compassion fatigue and ethical concerns during the COVID-19 pandemic.

Purpose:
To evaluate compassion fatigue of ICU nurses and their ethical attitudes in care during the COVID-19 pandemic and analyze contributing factors.

Methods:
An exploratory cross-sectional research design was used.

Results:
A total of 103 ICU nurses participated. The nurses' compassion fatigue and ethical attitude scores were high. Compassion fatigue was explained by the following variables: considering resigning, receiving support for ethical decisions, willingness to work in the ICU, duration of providing activities of daily living in a shift, and number of patients per nurse.

Conclusions:
Compassion fatigue was high in nurses working in the ICU during COVID-19. The high level of ethical attitudes shows commitment to professional ethics and reflects the development of the nurses' professional identity. Implementation of interventions that help improve compassion fatigue among nurses is needed.
Establishing a Pathway to Excellence® Research Agenda
Authors: Mulvey Tanya , Cámpoli Marcela , Lundmark Vicki 
Published: March 2023

OBJECTIVE
The aim of this study was to develop research priorities for positive practice environments identified by Pathway to Excellence® (Pathway) leaders and appraisers.

BACKGROUND
Identifying research priorities achieves 2 goals: 1) advancing research agendas that impact improving practice environments, and nurse and patient outcomes; and 2) informing nursing leaders, researchers, and funders of potential research projects to conduct and support.

METHODS
Research topics related to the 6 Pathway standards were developed and then rated for importance through 3 rounds of a Delphi survey by leaders at Pathway-designated organizations and Pathway appraisers.

RESULTS
Twenty research priorities were identified from the initial 54 research topics. The top 2 priorities were building and maintaining shared governance participation (91.9%) and nurse participation in performance improvement and evidence-based practice activities (90.7%).

CONCLUSIONS
Establishing a Pathway research agenda will guide nursing leadership, researchers, and funders in selecting impactful research priorities to help bolster positive practice environments that engage and empower nurses.
Components of Professional Practice Models
Authors: Wolf Zane Robinson , Cara Chantal , Bernard Noreen , Turkel Marian , Drenkard Karen 
Published: March 2023

OBJECTIVE
This study describes common components of nursing professional practice models (NPPMs) of Magnet®-designated nursing service organizations.

BACKGROUND
Components of professional practice models have not been consistently analyzed, suggesting a need to identify their concepts. Evidence-based guidelines may be unavailable to assist in the creation and revision of models.

METHODS
A checklist was used to analyze 56 Web-based NPPMs of Magnet-designated nursing departments.

RESULTS
Checklist items showed a match with parent organizations, an emphasis on patient- or family-centered care, a commitment to quality nursing services, and nursing's professional distinctiveness. Responses indicated engagement in shared governance and support of nursing staff's professional development. The concepts of health, care of sick and well people, and scope of nursing services were inconsistently addressed and call for further research.

CONCLUSION
Nurse leaders should examine concepts in NPPMs and the extent they distinguish nursing's professional identity both within and externally to the organization.
A Qualitative Study of Midlevel Nurse Managers' Perspectives of Scholarly Inquiry
Authors: Lombardo Mary Jo , Vioral Anna , Ley Cathaleen , Alderfer Mary Ellen , Mackay Periwinkle , Kverno Karan , Milburn Rowena Leong , Hohl Dawn , Lindauer Cathleen , Gerstenhaber Melissa 
Published: March 2023

OBJECTIVE
This study explored the key characteristics and needs of midlevel nurse managers (MLNMs) who support and engage clinical nurses (CNs) in scholarly inquiry.

BACKGROUND
Healthcare organizations expect CNs to participate in scholarly inquiry, incorporating evidence-based interventions to improve outcomes and safety. How the MLNM supports and engages CNs in scholarly inquiry remains unclear.

METHODS
Twelve semistructured interviews of MLNMs occurred at several facilities in the mid-Atlantic region utilizing the institutional review board–acknowledged protocol. Theme interpretation utilized inductive analysis.

RESULTS
Four recurrent themes emerged from the interviews related to the value of scholarly inquiry: 1) securing organizational resources to promote scholarly inquiry; 2) knowledge and experience in scholarly inquiry; 3) actions supporting scholarly inquiry; and 4) the value of scholarly inquiry within the organization.

CONCLUSIONS
Senior nursing leadership and healthcare organizations must recognize the value and provide the infrastructure to support scholarly inquiry. Infrastructure includes education, dedicated time, access to expertise, and resources.
The impact of running with and without a guide on short distance running performance for athletes with a vision impairment
Authors: Zenk Franziska , Willmott Ashley G. B. , Mann David L. , Allen Peter M. 
Published: March 2023

Abstract

Objective
This study aimed to investigate the difference of running with or without a guide on running performance (100 m, 200 m and 400 m) for athletes with a vision impairment (VI).

Design
Data including athletes’ and guides’ sex, age and race times were extracted from 11 elite competitions.

Results
Male athletes predominantly ran without a guide (100 m = 91.4%, 200 m = 88.1%, 400 m = 84.8%), whereas, female athletes mainly ran with a guide (100 m = 60.5%, 200 m = 80.0%, 400 m = 72.0%). No significant difference in 100 m race times was found between male athletes with or without a guide (p = 0.647). For the 200 m (p = 0.001) and 400 m (p = 0.030), race times were significantly slower for male athletes running with a guide (mean rank 200 m = 36.80, 400 m = 33.57) compared to without a guide (mean rank 200 m = 19.43, 400 m = 21.69). Conversely, 100 m (p = 0.015), 200 m (p = 0.025) and 400 m (p = 0.029) race times were significantly faster for female athletes with (mean rank 100 m = 18.25, 200 m = 13.71, 400 m = 11.00) compared to without a guide (mean rank 100 m = 27.74, 200 m = 22.67, 400 m = 21.69).

Conclusions
Running with a guide affects VI athletes’ race times. The influence of running with a guide, and the gender mix of VI athlete and guide, should be considered in any research with the aim of establishing a new classification system for VI athletes.
In the Cone of Concern: Preparing Stroke Survivors for Extreme Hurricanes
Authors: Issac Sony , Shultz James M. , Espinel Zelde , Alvarez Gemayaret , Shapiro Lauren T. 
Published: March 2023

ABSTRACT
When disasters strike, individuals living with stroke-related disability experience unique challenges and hardships. Climate change is contributing to the increasing frequency and severity of extreme weather events, including major hurricanes. Cyclonic storms that threaten the health and safety of residents living in coastal and island communities may disproportionately impact stroke survivors. Stroke sequelae may impede individuals’ abilities to engage in timely preparedness and self-protective actions when such storms approach. As such, it is imperative that physiatrists and other health care professionals caring for patients living with stroke proactively assist them in identifying their needs and in developing tailored, comprehensive emergency preparedness plans. In this paper, we examine the special needs of and considerations for persons living with stroke sequelae in the times leading up to, during, and after a major hurricane. We also put forward recommendations, specific to the phases of a disaster, regarding how physiatrists can assist patients living with stroke, and their caregivers, to optimize preparedness in advance of a hurricane, and facilitate effective response during storm impact and in the aftermath.
Effects of Orthopedic Manual Therapy on Pain Sensitization in Patients with Chronic Musculoskeletal Pain: An Umbrella Review with Meta-Meta-Analysis
Authors: Martínez-Pozas Oliver , Sánchez-Romero Eleuterio A. , Beltran-Alacreu Héctor , Arribas-Romano Alberto , Cuenca-Martínez Ferran , Villafañe Jorge Hugo , Fernández-Carnero Josué 
Published: March 2023

Abstract

Objective
The aim of this umbrella review with meta-meta-analysis was to assess the effectiveness of orthopedic manual therapy in isolation on pain sensitization in patients with chronic musculoskeletal pain.

Design
A systematic search was performed in different databases including systematic reviews with or without meta-analysis. The outcome measures included were pressure pain threshold, temporal summation, and conditioned pain modulation. We statistically synthesized the results of the different reviews through a random-effect meta-analysis of all standardized mean differences and the corresponding 95% confidence interval reported by each study.

Results
For mechanical hyperalgesia, the meta-meta-analysis of three meta-analysis revealed a statistically significant small-moderate effect of orthopedic manual therapy, with no evidence of heterogeneity and moderate quality evidence. In terms of temporal summation, one meta-analysis revealed a statistically significant small effect of orthopedic manual therapy intervention, with moderate heterogeneity and low quality of evidence. Finally, one review without meta-analysis found that orthopedic manual therapy improved endogenous analgesia with low quality evidence.

Conclusion
Orthopedic manual therapy in isolation improved mechanical hyperalgesia with moderate quality evidence, as well as temporal summation and conditioned pain modulation with low quality evidence. However, its effects are limited only to immediate and short-term.
Psychoeducational Intervention for Reducing Heart Failure Patients’ Rehospitalizations and Promoting Their Quality of Life and Posttraumatic Growth at the 1-Year Follow-Up: A Randomized Clinical Trial
Authors: de Oliveira Filipa Waihrich , Nunes Brenda Pereira , Lobato Fernanda Lucchese , Schmidt Márcia Moura 
Published: March 2023

ABSTRACT

Objective
This study’s aim was to verify whether a psychoeducational intervention, with a brief expressive posttraumatic growth (PTG) component, could reduce heart failure (HF) patients’ hospital readmissions and promote their quality of life (QoL) and PTG.

Methods
It adopted a parallel randomized clinical trial design, and its participants comprised HF patients from a hospital in Southern Brazil. All the participants completed the World Health Organization Quality of Life Assessment and Posttraumatic Growth Inventory questionnaires at the pre (T1: baseline) and post (T2) assessments of the intervention. Although patients in the control group (CG) underwent only regular outpatient consultations, those in the intervention group (IG) supplemented their regular consultations, with two additional individual visits to promote health and psychological education. At the 1-year follow-up, hospital readmissions were assessed.

Results
Of the 142 patients recruited at baseline (72 and 70 in the CG and IG, respectively), as 19 dropped out at follow-up, only 123 (63 and 60 in the CG and IG, respectively) were reassessed after approximately 378 days. They included 65% men aged 64 (11) years, 58% had low incomes, and 67% had less than high school education. The IG participants’ risk of readmission got reduced by 52% (p = .023), and they also showed significant improvements in their total QoL and positive psychological growth at the 6-month follow-up assessment.

Conclusions
The two-session psychoeducational intervention proved to be protective for Southern Brazilian HF patients in the IG, as it effectively reduced their hospital readmission rates by half compared with the CG, as well as improved their QoL and promoted their positive psychological growth.

Trial Registration

ClinicalTrials.gov identifier: NCT04870918.
Functional Somatic Disorders, Their Subtypes, and Their Association With Self-Rated Health in the German General Population
Authors: Sattel Heribert , Häuser Winfried , Schmalbach Bjarne , Brähler Elmar , Henningsen Peter , Hausteiner-Wiehle Constanze 
Published: March 2023

ABSTRACT

Objective
The heterogeneous conceptualizations and classifications of persistent and troublesome physical symptoms impede their adequate clinical management. Functional somatic disorder (FSD) is a recently suggested interface concept that is etiologically neutral and allows for dysfunctional psychobehavioral characteristics as well as somatic comorbidity. However, its prevalence and impact are not yet known.

Methods
We analyzed 2379 participants (mean age = 48.3 years, 52.5% female) from a representative German community survey using operationalized FSD criteria. These criteria defined FSD types based on somatic symptom count, type, and severity assessed by the Bodily Distress Syndrome Checklist. In addition, the associations of those types with health concerns, comorbidity, psychological distress, and self-rated health were determined.

Results
There were four clearly demarcated groups with no relevant bothering symptoms, with one or with few bothering symptoms from one organ system, and with multiple bothering symptoms from at least two organ systems. Psychological distress, health concerns, and comorbidity steadily increased, and self-rated health decreased according to the number and severity of symptoms. Somatic symptom burden, health concerns, and comorbidity independently predicted self-rated health, with no interaction effect between the latter two.

Conclusions
Our data support an FSD concept with two severity grades according to persistent and troublesome symptoms in one versus more organ systems. The delimitation of subtypes with psychobehavioral characteristics and/or with somatic comorbidity seems useful, while still allowing the demarcation of a group of participants with high symptom burden but without those additional characteristics.
Cardiac Magnetic Resonance Imaging T1 and T2 Mapping in Systemic Lupus Erythematosus in Relation to Antimalarial Treatment
Authors: Shalmon Tamar , Thavendiranathan Paaladinesh , Seidman Michael A. , Wald Rachel M. , Karur Gauri Rani , Harvey Paula J. , Akhtari Shadi , Osuntokun Tosin , Tselios Kostantinos , Gladman Dafna D. , Hanneman Kate 
Published: March 2023

Purpose:
Patients with systemic lupus erythematosus (SLE) are at risk of cardiac disease including antimalarial-induced cardiomyopathy (AMIC). The purpose of this study is to evaluate cardiac magnetic resonance imaging parametric mapping findings in SLE patients with AMIC and investigate the relationship of T1/T2 mapping to antimalarial (AM) treatment duration.

Materials and Methods:
All patients with SLE who had undergone cardiac magnetic resonance imaging with T1/T2 mapping for evaluation of suspected cardiac disease between 2018 and 2021 were evaluated and compared with healthy controls. To facilitate comparison between scanners, T1/T2 values were converted to a z-score using scanner-specific local reference values. Patients were classified into 3 groups: AMIC, myocarditis, and other (no AMIC or myocarditis).

Results:
Forty-five SLE patients (47±17 y, 80% female; 8 [18%] with AMIC and 7 [16%] with myocarditis) and 30 healthy controls (39±15 y, 60% female) were included. Patients with AMIC had higher T1 and T2 compared with controls (z-score 1.1±1.3 vs. 0±0.6, P=0.01 and 1.7±1.1 vs. 0±1.0, P<0.01, respectively) and lower values compared with those with myocarditis (3.7±1.6, P<0.01 and 4.0±2.0, P<0.01, respectively). T1 correlated negatively with AM treatment duration in patients without AMIC or myocarditis (r=−0.36, P=0.048) and positively in patients with AMIC (r=0.92, P=0.001). AM treatment duration did not correlate significantly with T1 in patients with myocarditis or with T2 in any group.

Conclusions:
The relationship between T1 and AM treatment duration differed between groups. Native T1 decreases with longer treatment in patients without AMIC or myocarditis, possibility due to glycosphingolipid accumulation. In patients with AMIC, increasing T1 with longer treatment could reflect fibrosis.
Are Interstitial Lung Abnormalities a Prognostic Factor of Worse Outcome in COVID-19 Pneumonia?
Authors: Colombi Davide , Petrini Marcello , Morelli Nicola , Silva Mario , Milanese Gianluca , Sverzellati Nicola , Michieletti Emanuele 
Published: March 2023

Purpose:
To assess the association between interstitial lung abnormalities (ILAs) and worse outcome in patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19)-related pneumonia.

Materials and Methods:
The study included patients older than 18 years, who were admitted at the emergency department between February 29 and April 30, 2020 with findings of COVID-19 pneumonia at chest computed tomography (CT), with positive reverse-transcription polymerase chain reaction nasal-pharyngeal swab for SARS-CoV-2, and with the availability of prepandemic chest CT. Prepandemic CTs were reviewed for the presence of ILAs, categorized as fibrotic in cases with associated architectural distortion, bronchiectasis, or honeycombing. Worse outcome was defined as intensive care unit (ICU) admission or death. Cox proportional hazards regression analysis was used to test the association between ICU admission/death and preexisting ILAs.

Results:
The study included 147 patients (median age 73 y old; 95% CIs: 71-76-y old; 29% females). On prepandemic CTs, ILA were identified in 33/147 (22%) of the patients, 63% of which were fibrotic ILAs. Fibrotic ILAs were associated with higher risk of ICU admission or death in patients with COVID-19 pneumonia (hazard ratios: 2.73, 95% CIs: 1.50-4.97, P=0.001).

Conclusions:
In patients affected by COVID-19 pneumonia, preexisting fibrotic ILAs were an independent predictor of worse prognosis, with a 2.7 times increased risk of ICU admission or death. Chest CT scans obtained before the diagnosis of COVID-19 pneumonia should be carefully reviewed for the presence and characterization of ILAs.
Association of rare variants inARSAwith Parkinson’s disease
Authors: Senkevich Konstantin , Beletskaia Mariia , Dworkind Aliza , Yu Eric , Ahmad Jamil , Ruskey Jennifer A. , Asayesh Farnaz , Spiegelman Dan , Fahn Stanley , Waters Cheryl , Monchi Oury , Dauvilliers Yves , Dupré Nicolas , Greenbaum Lior , Hassin-Baer Sharon , Nagornov Ilya , Tyurin Alexandr , Miliukhina Irina , Timofeeva Alla , Emelyanov Anton , Zakharova Ekaterina , Alcalay Roy N. , Pchelina Sofya , Gan-Or Ziv 
Published: March 2023

AbstractBackgroundSeveral lysosomal genes are associated with Parkinson’s disease (PD), yet the association between PD andARSA, which encodes for the enzyme arylsulfatase A, remains controversial.ObjectivesTo evaluate the association between rareARSAvariants and PD.MethodsTo study possible association of rare variants (minor allele frequency<0.01) inARSAwith PD, we performed burden analyses in six independent cohorts with a total of 5,801 PD patients and 20,475 controls, using optimized sequence Kernel association test (SKAT-O), followed by a meta-analysis.ResultsWe found evidence for an association between functionalARSAvariants and PD in four independent cohorts (P≤0.05 in each) and in the meta-analysis (P=0.042). We also found an association between loss-of-function variants and PD in the UKBB cohort (P=0.005) and in the meta-analysis (P=0.049). However, despite replicating in four independent cohorts, these results should be interpreted with caution as no association survived correction for multiple comparisons. Additionally, we describe two families with potential co-segregation of theARSAvariant p.E384K and PD.ConclusionsRare functional and loss-of-functionARSAvariants may be associated with PD. Further replication in large case-control cohorts and in familial studies is required to confirm these associations.
Role of MicroRNA-22 (miR-22)/Specificity protein 1 (Sp1)/Cystathionine β-synthase (CBS) axis in regulating trophoblast invasion: an in vitro study
Authors: Arora Pallavi , Mochan Sankat , Gupta Sunil Kumar , Rani Neerja , Kshetrapal Pallavi , Dwivedi Sadanand , Bhatla Neerja , Dhingra Renu 
Published: March 2023

AbstractIntroductionPlacenta expresses many ubiquitous as well as specific miRNAs which regulate trophoblast cell differentiation, proliferation, apoptosis, invasion, migration, and angiogenesis. Aberrant miRNAs expression (miR-22) has been linked to pregnancy complications, such as preeclampsia. Specificity protein 1 (Sp1) was identified a direct target of miR-22 and an inverse linear correlation between expression of miR-22 and Sp1 mRNA in gastric tumour has been reported. Also, Sp1 has a critical and indispensable role in the regulation of cystathionine β-synthase (H2S synthesizing enzyme). Exogenous H2S could promote cell proliferation and invasion by upregulating the expression of MMP-2 and MMP-9 in human bladder cancer EJ cells. Worldwide studies reported significant role of MMP-2 and MMP-9 in the regulation of trophoblast invasion.Aims and ObjectivesTo determine the role of MicroRNA-22 (miR-22)/Specificity protein 1 (Sp1)/Cystathionine β-synthase (CBS) axis in regulating trophoblast invasion in the first-trimester trophoblast cells.Materials and methodsThe human first trimester trophoblast cell line (HTR-8/SVneo Cell line) was procured from American Type Culture Collection. Gain/Loss of function studies were conducted on HTR-8/SVneo cells and the expression of miR-22 (pre miR-22 and miR-22-3p), Sp1, CBS, MMP-2 and MMP-9 was observed. Invasion capacity of the cells was assessed by transwell invasion assay. Data were analyzed by STATA 14 and Graph Pad Prism 8.ResultsSignificantly down regulated regulated mRNA and protein expression of Sp1, CBS and and MMPs 2, 9 was observed when the cells were transfected with miR-22-3p mimic in comparison to miR-22-3p inhibitor transfected cells. Expression of CBS and MMPs 2, 9 was found to be significantly up regulated when the cells were transfected with Sp1 plasmid as compared to Sp1 inhibitor (2,4,5 trifluoroaniline) treated cells at both transcription and translation levels. MMP-2 and MMP-9 levels were found to be significantly elevated when the cells were subjected to NaHS [sodium hydrogen sulphide (H2S donor)] treatment as compared to AOAA (aminooxyacetic acid) treated cells.ConclusionThis is the first study which implies that miR-22 via targeting Sp1 must have influenced the mRNA and protein expression of CBS, MMP-2 and MMP-9 in order to regulate the trophoblast invasion.
Mindfulness Training and Health-Related Quality of Life in Male NCAA Division I Athletes
Authors: Haraldsdottir Kristin , Anderson Scott , Sanfilippo Jennifer , McGehee Chad , Watson Andrew M 
Published: March 2023

AbstractObjectiveTo examine the effects of a mindfulness intervention on mental and physical quality of life (QOL) among male collegiate athletes.Participants327 male Division I collegiate athletes.MethodsQOL was measured among 527 participants using the Veterans Rand-12 survey twice annually from 2017-2020. 101 athletes underwent 6-week mindfulness training in spring 2019. The influence of mindfulness on mental and physical QOL scores (MCS, PCS) was evaluated using linear mixed effects models with season (winter, summer), group (mindfulness, control), time (pre/post-intervention) and time*group interaction as fixed effects and individual as a random effect.ResultsPCS was associated with the interaction between time and group (β=1.05±0.51, p=0.04) and season (β=-0.80±0.24, p=0.001), but not time (β=-0.40±0.37, p=0.27) or group (β=0.43±0.44, p=0.33).ConclusionMindfulness training is associated with improved physical QOL among male collegiate athletes, but did not appear to be associated with differences in mental QOL.