bluuebunny/crossref_metadata_2025_split huggingface dataset:
BloodCircR: A Comprehensive Database for Human Peripheral Blood Circular RNAs
Authors: Yuan Shaoxun , Gu Wanjun 
Published: January 2025

Abstract

Background: Blood circular RNAs (circRNAs) are stable, noncoding RNAs with diverse functional roles. However, a comprehensive resource for blood-derived circRNAs is lacking. We developed BloodCircR, a database of circRNAs from human peripheral blood, to support research on circRNAs in disease and biomarker discovery.
Methods: BloodCircR integrates circRNAs identified from 89 human blood RNA-seq datasets, comprising 5,430 samples across 58 diseases categorized into 16 groups. Full-length circRNAs were identified using CIRI-full and supplemented with data from public databases. The platform provides detailed annotations and tools for exploring circRNA expression and differential expression.
Results: The database includes approximately 2.3 million circRNAs, of which over 1.7 million are exonic. Most circRNAs are full-length, with a substantial proportion derived from infectious disease datasets. Functional annotations suggest their interactions with miRNAs and RNA-binding proteins, while expression analysis supports the investigation of circRNA roles in disease.
Conclusions: BloodCircR is a comprehensive resource for exploring circRNAs in human blood, offering significant insights into their potential as biomarkers and therapeutic targets.
Co-administration of Naringin and NLRP3 Inhibitor Improves Myelin Repair and Mitigates Oxidative Stress in Cuprizone-Induced Demyelination Model
Authors: Kalaki-Jouybari Fatemeh , Shirzad Moein , Javan Mohammad , Ghasemi-Kasman Maryam , Pouramir Mehdi 
Published: January 2025

Background:
Naringin and MCC950 as an inflammasome inhibitor have exhibited numerous
pharmacological activities, including antioxidant and anti-inflammatory effects. The present study
has examined the combined impacts of naringin and MCC950 on the levels of oxidative stress, demyelination,
and inflammation in the cuprizone (CPZ)-induced demyelination model.

Methods:
In order to induce demyelination, CPZ (0.2% w/w) was added to the normal diet of mice for
42 days. Subsequently, the male C57BL/6 mice received naringin (oral administration), MCC950 (intraperitoneal
injection), or their combination for 14 days. Working memory was tested by the Y maze.
FluoroMyelin staining, MOG, and GFAP immunostaining assessed the demyelination extent, myelin
intensity, and astrocyte activation, respectively. Oxidant/antioxidant biomarkers were measured using
colorimetric techniques. The expression levels of MBP, PDGFRα, Olig2, Nrf2, HO-1, NQO-1, GSK3β,
IL1β, and IL18 were assessed by reverse transcription-quantitative polymerase chain reaction
(RT-qPCR).

Results:
Our results indicated that the co-administration of naringin and MCC950 improved working
memory and antioxidant capacity. A significant reduction was found in the extent of demyelination
and inflammatory mediatorsin naringin and MCC950-treated mice. In addition, co-administration of
naringin and MCC950 elevated the expression levels of pro-myelinating and antioxidant markers.

Conclusion:
These findings indicated improvement of the working memory through co-administration
of naringin and MCC950, which might be partly mediated by enhancing antioxidant capacity, promoting
remyelination, and mitigating inflammation in the CPZ-induced demyelination model.
Effect of a Hyperkyphosis-specific Exercise Program on the History of Falls, Fear of Falling and Satisfaction in Older People with Hyperkyphosis: A Pilot Study
Authors: Duangkaew Roongtip , Bettany-Saltikov Josette , Van Schaik Paul , Kandasamy Gok 
Published: January 2025

Background:
Hyperkyphosis, an excessive curvature of the upper back, has been linked to increased falls and fear of falling. Previous work has focused on improving the hyperkyphosis curve itself. There is, however, a dearth of studies that have focused on improving falls, fear of falling, and participants’ satisfaction with the educational material.

Objective:
This study aimed to determine the effect of a hyperkyphotic-specific exercise programme on falling, fear of falling, and satisfaction with the educational material.

Methods:
Thirteen individuals with a hyperkyphosis of over 40 degrees were randomly divided into an exercise group (n=6; age: 71.50 ± 7.84 years) and a control group (n=7; age: 67.29 ± 9.76 years). The exercise group received a 16-week hyperkyphosis-specific exercise programme with educational material. The control group received only the educational material. Before and after the exercise programme, the history of falls in the past year and fear of falling were assessed by 2 questionnaires (the history of falls in the past year and the Fall Efficacy Scale-International). Satisfaction with the educational material was evaluated after the exercise programme. Data were analysed by descriptive statistics and a 2×2 model mixed between-within subjects analysis of variance.

Results:
There was no significant interaction between group and time for the history of falls in the past year (p = .182, effect size = .156) and fear of falling (p = .216, effect size = .135), but the effect size of the interaction effect was large. Furthermore, participants in both groups expressed positive satisfaction with the educational material.

Conclusion:
Hyperkyphosis-specific exercise programme resulted in improvement in the history of falls and fear of falling, but the results were not significant. A larger randomised controlled trial is needed to clarify the effectiveness of the exercise programme in reducing the number of falls and fear of falling in this population.
Strategically Timed Voluntary Disclosures before Conferences: Global Evidence
Authors: Wang Emily Jing , Wang Shiheng 
Published: January 2025

ABSTRACT
This study examines how firms strategically time their voluntary disclosures before attending conferences in the global market. We document four findings. First, conference firms provide more voluntary disclosures of positive news and experience better stock performance in the month before conferences than in the month after. Second, firms that attend low-visibility conferences, have limited conference experience, face greater shareholder pressure, or have less concentrated ownership are more likely to increase their voluntary disclosures of positive news before conferences. Third, non-U.S. firms domiciled in jurisdictions with stronger investor protection and financial institutions are more likely to increase their voluntary disclosures of positive news and experience a stock price run-up before conferences. Finally, positive news disclosures before conferences attract more favorable market reactions to conference presentations and greater analyst following and institutional holdings. Overall, conference firms in the global market strategically coordinate their disclosures to maximize the economic impacts of conference attendance.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: G14; G15; M41.
Properties of New Partially Crystallized Lithium Disilicate CAD-CAM Materials
Authors: Wells JM , Johnson JW , Lien W , Raimondi C , Caballero M , Gibbons TF , Vandewalle KS 
Published: January 2025

SUMMARY

Objective:
The purpose of this study was to compare the optical, mechanical, and biological properties of two new, inexpensive lithium disilicate (LS2) materials (Lodden (LOD), LD Medical Technology; and BeautyZir (BZ), BeautyZir Technology) to a clinically established LS2 material (IPS e.max CAD (EMAX), Ivoclar Vivadent).

Methods and Materials:
The optical properties of the translucency parameter (TP) and opalescence parameter (OP) were obtained with a dental spectrophotometer. The mechanical properties of flexural strength (FS) and flexural modulus (FM) were determined through a three-point bend test conducted using a universal testing machine. Biocompatibility tests were conducted by analyzing cell proliferation using spectrophotometric absorbance (optical density) to determine relative growth rate and cytotoxicity. Representative specimens of the three LS2 materials were analyzed with X-ray diffraction to determine the relative crystalline phases. Data were analyzed with oneway ANOVA and Tukey’s post hoc test (α=0.05).

Results:
Significant differences in optical and mechanical properties were found amongst the groups (p&lt;0.05). Both LOD and BZ had significantly greater TP and OP compared to EMAX. EMAX and LOD had greater FS and FM than BZ. No significant differences in optical density or relative growth rate were found among any of the LS2 groups (p&gt;0.05). EMAX and LOD had greater weight percent of lithium disilicate than BZ.

Conclusions:
The new lithium disilicate LS2 material, LOD, exhibited better optical properties while maintaining mechanical and biological properties similar to the established LS2 material, EMAX.
Portfolio Assessment to Measuring Capabilities Communications and Collaborations Students
Authors: Rizal M. Khairu Rizal , Dwi Yulianti  , Handoko  , Rosidin Undang 
Published: January 2025

Assessments that can measure students' cognitive, affective and psychomotor abilities comprehensively are needed because assessments are currently only carried out at the end of learning and are only oriented to written tests and assignments. This study aims to produce a valid and effective portfolio assessment to measure the communication and collaboration skills of grade V elementary school students. This research is a type of Research and Development (R&D) research using the Borg & Gall model. The subjects of the study are material experts, linguists, and evaluation experts. The methods used in data collection are observation, interviews, questionnaires and tests. Data collection instruments in the form of questionnaire sheets and tests. Data analysis techniques use qualitative, quantitative, and statistical inferential descriptive analysis. The results of the study, namely Portfolio Assessment, get valid and very practical qualifications. The results of the T-test show that there is a difference between the pretest and post-test results in students. It was concluded that portfolio assessment effectively improves students' communication and collaboration skills. The implication of this research is that the portfolio assessment developed can be used by teachers in learning.
Effect of Age on Semen Quality and Freezability in Sahiwal Bulls
Authors: Gautam Anshul , Singh Pawan , Sriranga K. R. , Arya Shruti 
Published: January 2025

The study was conducted at ICAR-National Dairy Research Institute, Karnal, Haryana, India during Feb–May 2023 to find out the age window at which the bull produces quality semen. Fifteen Sahiwal bulls were selected and classified into three age groups (n=5 in each group) -(2–3.5), (>3.5–8) and (>8–12) years. Semen was collected twice a week with two ejaculates on each collection. Fresh and extended frozen semen was analysed at fortnightly interval. The data was subjected to statistical analysis by one-way Analysis of Variance (ANOVA) using SPSS software version 26.0 to draw scientific inferences. The results revealed that the mean value of semen volume (ml), sperm concentration (106 ml-1), mass motility was high (p<0.05) in the >8-12 age group. Individual motility was high (p<0.05) in the >3.5–8 age group. Mean value of viability (%), HOST (%), Acrosome integrity (%) was lower in 2-3.5 age group for fresh as well as frozen semen. Post thaw motility was high (p<0.05) in >3.5-8 age group. In incubation test, the post thaw motility of the >3.5–8 age group was high (p<0.05) at 0, 90 and 120 min. Therefore, it can be concluded from the study that semen quality of Sahiwal bulls is influenced by age and it is better to use Sahiwal bulls only after 3.5 years of age and best semen quality is obtained from bulls of >3.5-8 years of age.
Morphometric Characterization and Haemato-biochemical Profile of Indian Fruit Bats
Authors: Dave K. M. , Raval S. K. , Rao Neha , Nayak J. B. , Kanani A. N. , Patel Beena , Panchal M. T. , Patel P. V. 
Published: January 2025

The present study was conducted during January–December, 2022 at the Department of Veterinary Medicine, College of Veterinary Science & A.H., Kamdhenu University, Anand, Gujarat, India to study the normal values of haematological and biochemical parameters in both males and females of P. giganteus and C. spinx. In the study period, samples were collected from different district of Gujarat viz., Ahmedabad, Navsari and Valsad. In which two species of the fruit bats, P. gigantus (n=4) and C.sphinx (n=10) were screened for the morphometric identification. Based on morphometry both the species were identified. The haematology was performed in 27 fruit bats (Pteropus giganteus, n=13; Cynopterus sphinx, n=14) and biochemical analysis was carried out in 28 fruit bats (Pteropus giganteus, n=16; Cynopterus sphinx, n=12). In haematology, mean Hb, PCV and TLC were observed higher in P. gigantus than C.sphinx, whereas the value of TEC was lower. Between the species and sexes, hemoglobin and packed cell volume (PCV) values were comparatively equal, indicating similar oxygen-carrying capacity. In serum biochemistry, mean value of Creatinine, ALT, Total protein and BUN was observed higher in P. gigantus, whereas the AST was found high in C.sphinx. In comparison between male and female, the higher value of Creatinine and Total protein were found in male, whereas ALT, AST and BUN was found higher in female.
Mohammed Arkoun's Islamology: Applications of Humanities and Social Sciences in Islamic Studies
Authors: Pratama Aunillah Reza , Masruchin Masruchin 
Published: January 2025

Abstract;This study focuses on Arkoun's thoughts on the idea of Applied Islamology. Arkoun has anxiety about the treasures of Islamic turats (heritage of tradition, culture, knowledge) which tend to be passive towards advanced civilization in thought. Such stagnation, according to Arkoun, is caused by the hegemony of dogmatic orthodoxy that shackles knowledge into the old episteme. Arkoun's Applied Islamology is a scientific practice in an epistemology of thought. By using the literature method, this study found that the reading of QS. At-Taubah: 5 there is a fairly strong normative foundation about jihad and today's problems regarding it. The results of the reading with several perspectives, namely: from the semiotic side, all vocabulary in Surah At-Taubah is related to the meaning of taubah, including prayer, zakat, faith and disbelief.Keywords:Applied Islamology; Arkoun; Episteme; Socio-Humanities Applications. Abstrak;Kajian ini berfokus pada pemikiran Arkoun tentang gagasan Islamologi Terapan. Arkoun memiliki kegelisahan terhadap khazanah turats Islam (warisan tradisi, kebudayaan, pengetahuan) yang cenderung pasif untuk menuju peradaban maju dalam pemikiran. Kejumudan demikian menurut Arkoun disebabkan oleh hegemoni ortodoksi-dogmatis yang membelenggu pengetahuan ke dalam episteme lama. Islamologi Terapan yang dicetus oleh Arkoun merupakan suatu praktik ilmiah dalam suatu epistemologi pemikiran. Dengan menggunakan metode pustaka, penelitian ini menghasilkan bahwa pembacaan terhadap QS. At-Taubah terdapat landasan normative yang cukup kuat tentang jihad dan problem dewasa ini mengenai hal tersebut. Dalam kasus at-Taubah ini, ayat payung ini adalah ayat saif atau pedang. Ayat pedang yang dimaksud adalah QS. At-Taubah: 5. Hasil pembacaannya dengan beberapa perspektif yaitu: dari sisi semiotik, semua kosa kata dalam surat at-Taubah berkaitan dengan makna taubah, termasuk salat, zakat, iman, kafir.Kata Kunci: Aplikasi Ilmu Sosial-Humaniora; Arkoun; Episteme; Islamologi Terapan.
Epistemologi Positivisme Auguste Comte
Authors: Jubaedah Siti , Hayati Ela Hikmah 
Published: January 2025

Abstract;The purpose of this research is to examine Auguste Comte's postivism epistemology consisting of social positivism, evolutionary positivism and critical positivism, all of which will be discussed with ethical values in science. This research uses literature method with epistemology approach. This research shows that Auguste Comte has shown that in the development of the human soul, both individually and as a whole, there is progress. That progress will be achieved, when the development comes, at the time called positive.Keywords:Auguste Comte; Critical; Epistemology; Evolutioneri; Social Positivism. Abstrak;Tujuan penelitian ini untung mengkaji Epistemologi postivisme Auguste Comte yang terdiri dari positivisme sosial, positivisme evolusioner dan positivisme kritis yang ketiganya akan dibahas dengan nilai-nilai etis dalam ilmu sains. Penelitian ini menggunakan metode kepustakaan dengan pendekataan epistemology. Dari penelitian ini menunjukkan hasil bahwa Aguste Comte telah menunjukkan bahwa didalam perkembangan jiwa manusia, baik secara individual maupun secara keseluruhan, terdapat suatu kemajuan. Kemajuan itu akan dicapai, pada saat perkembangan datang, pada saat yang disebut positif. Kata Kunci: Auguste Comte; Epistemologi; Positivisme Sosial; Evolusioner; Kritis.
Satisfacción laboral en técnicos deportivos de barranquismo y media montaña
Authors: Rojo-Ramos Jorge , Mogo´´llón-Espinosa Laura , Gomez-Paniagua Santiago , Galán Arroyo Carmen 
Published: January 2025

La satisfacción laboral es un estado emocional que identifica la percepción subjetiva con sus experiencias y expectativas en el trabajo. Esto puede afectar a la calidad del servicio que se ofrece. Con el fin de conocer la satisfacción laboral de los técnicos deportivos especializados en barranquismo y media montaña, se ha aplicado la escala de satisfacción laboral para técnicos deportivos desarrollada por Sánchez Alcazar Martínez y Parra Meroño en una muestra de 114 empleados. Los resultados obtenidos coinciden con los observados por otros autores donde las dimensiones mejor valoradas son “seguridad” y “promoción”, siendo la “remuneración” la que obtuvo valores más bajos. Además, se ha identificado la “edad” y la “experiencia” como variables que influyen en algunas de las áreas. Sería importante ampliar el estudio y tratar las variables que influyen en la satisfacción laboral de los técnicos deportivos especializados en barranquismo, con el fin no solo de aumentar su calidad de vida, si no de mejorar la calidad del servicio prestado.

PALABRAS CLAVE: bienestar laboral, deportes de aventura, ambiente laboral, monitor, guía deportivo
Comparative Analysis of Hedonic Wage and Discrete Choice Models in Valuing Job Safety
Authors: Zhang Nan 
Published: January 2025

Abstract
This is the first study to compare the hedonic wage and discrete choice models in the context of real job market choices. The hedonic wage method is the most widely adopted approach in estimating the value of marginal changes in mortality risks (or value of a statistical life, VSL). Alternatively, the discrete choice model offers a framework for valuing non-market goods, often used in choice experiments involving hypothetical job selection scenarios. This study employs both the hedonic wage and discrete choice models, using real market data from Taiwan‘s Panel Survey of Family Dynamics (PSFD 2016-2018), to examine workers‘ industry choices and infer their willingness to pay for job safety. By comparing the estimation results from the discrete choice model and the hedonic wage model, this study finds that the marginal willingness to pay (MWTP) for risk reduction estimated from discrete choice models is unreasonably large and therefore prefers the hedonic wage model in estimating the value of job safety. The findings of this study contribute to the literature comparing the hedonic model and the discrete choice model in evaluating environmental goods, which are mainly conducted using housing market data.
Impact of four hydroponic nutrient solutions and regrowth on yield, safety and essential oil profile of basil (Ocimum basilicum L.) cultivated in soilless culture systems
Authors: Hazrati Saeid , Pignata Giuseppe , Casale Manuela , Binello Arianna , Cravotto Giancarlo , Devecchi Marco , Nicola Silvana 
Published: January 2025

ABSTRACT
Herb production in soilless culture systems (SCSs) requires precise composition of hydroponic nutrient solutions (HNSs) to optimise growth, yield and quality. This study aimed to investigate the effect of four nutrient solutions having different ion concentrations on the yield, quality and safety of basil grown in a New Growing System (NGS®) at two harvest times. The results showed that as ion concentration increased, yield and leaf fresh weight decreased, while total dry matter varied with harvest time. Lower levels of phosphorus and potassium in the HNS increased nitrate concentration in basil leaves, with higher nitrogen specifically increasing nitrate levels, and the second harvest showed the highest concentration in the N12P2K6 (nitrogen: 12 mmol · L−1; phosphorus: 2 mmol · L−1; potassium: 6 mmol · L−1) treatment. This study showed that SCS was successful in reducing the growth of microbial contamination, with the lowest levels of mould and yeast contamination detected in nutrient solutions containing N6P4K12. HNS affected the contents of essential oil compounds such as linalool (the highest amount at the lowest ion concentration) and (E)-α-bergamotene (the highest amount at the highest ion concentration). In conclusion, the quantity, quality and microbiological contamination of basil grown in NGS® depend on the HNS used and harvesting time.
Too old for a life-threatening inherited cardiac condition? The importance of cascade genetic testing
Authors: Hrib Luciana Andreea , Hadarag Andra Valeria , Casian Mihnea , Papadakis Michael 
Published: January 2025

Abstract

Introduction
CPVT is a rare inherited channelopathy which predisposes patients to malignant ventricular arrhythmias during exercise or stress. Although exceptionally rare, the diagnosis can be made in individuals over 40 years.

Case presentation
A 58-year-old male with persistent atrial fibrillation was evaluated for exercise prescription. He was keen on low-intensity skill sports and medium-intensity endurance sports. He reported no symptoms and had no relevant family history. The ECG showed atrial fibrillation without other abnormalities. The transthoracic echocardiogram demonstrated severe left atrial dilatation but nothing else of note. The exercise test revealed a poorly controlled ventricular rate with effort, with frequent monomorphic PVC and a 4-beat NSVT. The CTCA and CMR excluded significant coronary artery disease or an underlying cardiomyopathy. The bisoprolol dose was increased, and the patient was advised to limit his training to moderate-intensity exercise. In the meantime, the patient’s 25-year-old daughter suffered a sudden cardiac arrest and was found to harbor a pathogenic RYR2 mutation, later identified in our patient through predictive genetic testing. The patient was reassessed considering the genetic result. An exercise test revealed bi-directional PVCs. He was switched on a non-selective beta-blocker. Specific exercise prescription and lifestyle changes were discussed.

Conclusion
Genetic testing in CPVT is crucial for diagnosis and prognosis of affected individuals, as well as for identifying family members at risk, even in the absence of a characteristic phenotype.