bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is there a role for hyperthermic intraperitoneal chemotherapy in ovarian cancer?
Authors: Praiss Aaron M. , Moukarzel Lea A. , Zivanovic Oliver 
Published: January 2023

Purpose of review
Our objective is to provide a history, rationale, and review of the use of hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of ovarian cancer.

Recent findings
In the last decade, there has been an increase in the literature regarding HIPEC in the treatment of ovarian cancer. The rationale for HIPEC extends from earlier trials demonstrating improved survival using intraperitoneal chemotherapy. HIPEC provides a one-time opportunity for intraperitoneal chemotherapy at the time of cytoreduction and with the addition of hyperthermia. Cisplatin HIPEC has been demonstrated to have a survival benefit when used in the interval cytoreductive setting. In terms of safety, nephroprotection remains a key concern when administering HIPEC. Sodium thiosulfate provides nephroprotection and should be considered when performing HIPEC. Various institutions have created multidisciplinary protocols for administering HIPEC, which include operating room staff, nursing, anesthesia, pharmacy, and surgical teams.

Summary
HIPEC has a role in the treatment paradigm of ovarian cancer. Currently, HIPEC is approved in the interval cytoreductive surgery setting. Further trials are needed to understand the appropriate timing, chemotherapeutic agents, and protocolization of HIPEC.
The influence of age and sex on the prognostic importance of traditional cardiovascular risk factors, selected circulating biomarkers and other markers of subclinical cardiovascular damage
Authors: Olesen Thomas Bastholm , Pareek Manan , Vishram-Nielsen Julie K.K. , Olsen Michael Hecht 
Published: January 2023

Purpose of review
There is an increasing need for improved risk stratification to better individualize cardiovascular preventive measures. Although age and sex are strong and easily obtained cardiovascular risk factors (CVRFs), their influence on the prognostic importance of other CVRF, circulating biomarkers and other markers of subclinical cardiovascular damage has not previously been systematically and critically appraised. Therefore, we have revisited the European MORGAM and the Danish MONI10 cohorts.

Recent findings
Theoretically, the relative risk of many CVRF is expected to be lower in older healthy individuals due to a combination of selection bias by disease, higher absolute risk primarily due to older age, and the fact that the CVRF and markers may primarily influence or reflect early parts of the cardiovascular disease process. This influence of age may vary between sexes, as the cardiovascular disease process is delayed and possibly different in women compared with men.

Summary
Adjusted for the remaining Systematic COronary Risk Evaluation (SCORE) CVRF, higher SBP, serum cholesterol, soluble urokinase-type plasminogen activator receptor, left ventricular mass index and atherosclerotic plaques were more closely associated with outcomes in individuals younger than 52 years with some sex-specific differences, whereas higher N-terminal pro-brain natriuretic peptide and urine albumin/creatine ratio were more closely associated with outcomes in subjects aged 61 or 71 years.
Conjunctival Melanoma in 430 Cases: Comparative Analysis of the Impact of Orbital Invasion on Tumor Recurrence, Metastasis, and Death
Authors: Bas Zeynep , Dockery Philip W. , Lally Sara E. , Shields Jerry A. , Shields Carol L. 
Published: January 2023

Purpose:
To compare the clinical features at presentation and treatment outcomes of conjunctival melanoma by absence/presence of orbital invasion.

Methods:
A retrospective review of patients with conjunctival melanoma managed at a single tertiary referral center from April 18, 1974, to September 9, 2019.

Results:
Of 430 patients with conjunctival melanoma, 21 (5%) had orbital invasion at presentation. A comparison between the 2 groups (orbital invasion absent vs. present) revealed that the orbital invasion group had a higher frequency of prior eyelid incisional biopsy (5% vs. 24%, P = 0.006), greater tumor basal diameter (12.2 vs. 17.3, P = 0.009), greater tumor thickness (2.4 vs. 7.0, P < 0.001), more quadrants involved (1.8 vs. 2.5, P = 0.002), and more clock hours involved (4.4 vs. 5.8, P = 0.037). In addition, those with orbital invasion were more likely to undergo exenteration as primary treatment (1% vs. 24%, P < 0.001). Multivariate relative risk regression analysis revealed that variables predictive of orbital invasion included greater tumor thickness (P < 0.001) and greater involvement of the fornix (P = 0.031) and tarsus (P = 0.033). Outcomes revealed orbital invasion group with greater 5-year/10-year distant metastatic rate (16%/21% vs. 63%/63%, P = 0.005), and greater melanoma-related death rate (7%/13% vs. 38%/53%, P = 0.001).

Conclusions:
Conjunctival melanoma with orbital invasion at presentation demonstrate larger, more extensive tumors involving the fornix or tarsus, and with greater rate of melanoma-related metastasis and death.
Building a Foundation for Health Informatics Content in Physical Therapy Education Through Concept Analysis and Concept Mapping
Authors: Chevan Julia , Pak Sang S. , Wilkinson Steven G. , Toole Eric 
Published: January 2023

Introduction.
Health informatics curricular content, while beneficial to the spectrum of education in physical therapy, is currently only required in physical therapist education programs, and even there, it is only crudely defined. The purpose of our study was to use the techniques of concept analysis and concept mapping to provide an outline of informatics content that can be the foundation for curriculum development and the construction of informatics competencies for physical therapy.

Review of Literature.
There is no established consensus on the definition of health informatics. Medical and nursing informatics literature that clarifies and agrees on the attributes of health informatics is insufficient for curriculum development. Concept analysis is an approach commonly used in nursing and other health professions to analyze and deconstruct a term, in this case, health informatics, in order to provide clarity on its meaning.

Subjects.
A total of 73 definitions of health informatics were extracted from articles that met search criteria.

Methods.
We used an 8-step methodology from the literature for concept analysis, which included 1) selecting a concept; 2) determining the aims of the analysis; 3) identifying uses of the concept; 4) determining the defining attributes of the concept; 5) identifying a model case; 6) identifying related and illegitimate cases; 7) identifying antecedents and consequences; and 8) defining empirical referents. In addition, concept mapping was used to develop a visual representation of the thematic attributes and the elements that make them up.

Results.
We provide a visual map of the concept we now term “informatics in human health and health care” and clarify its attributes of data, disciplinary lens, multidisciplinary science, technology, and application. We also provide clarification through the presentation of a model case and a contrary case.

Discussion and Conclusion.
Concept analysis and mapping of informatics in human health and health care provided clarity on content that should be addressed across the continuum of physical therapy education. The next steps from this work will be to develop competencies for all levels of physical therapy education.
Kidney absorbed radiation doses for [177Lu]Lu-PSMA-617 and [177Lu]Lu-PSMA-I&T determined by 3D clinical dosimetry
Authors: Uijen Maike J.M. , Privé Bastiaan M. , van Herpen Carla M.L. , Westdorp Harm , van Gemert Willemijn A. , de Bakker Maarten , Gotthardt Martin , Konijnenberg Mark W. , Peters Steffie M.B. , Nagarajah James 
Published: January 2023

Purpose
For prostate-specific membrane antigen-directed radioligand therapy (PSMA-RLT), [177Lu]Lu-PSMA-617 and [177Lu]Lu-PSMA-I&T are the currently preferred compounds. Recent preclinical studies suggested ~30x higher kidney absorbed dose for [177Lu]Lu-PSMA-I&T compared to [177Lu]Lu-PSMA-617, which may lead to an increased risk of kidney toxicity. We performed two single-centre, prospective dosimetry studies with either [177Lu]Lu-PSMA-617 or [177Lu]Lu-PSMA-I&T, using an identical dosimetry protocol. We evaluated the absorbed doses of both 177Lu-labelled radioligands in human kidneys.

Methods
3D SPECT/computed tomography (CT) imaging of the kidneys was performed after PSMA-RLT in cancer patients with PSMA-positive disease and an adequate glomerular filtration rate (≥50 mL/min). Ten metastatic hormone-sensitive prostate cancer patients (mHSPC) were treated with [177Lu]Lu-PSMA-617 and 10 advanced salivary gland cancer (SGC) patients were treated with [177Lu]Lu-PSMA-I&T. SPECT/CT imaging was performed at five timepoints (1 h, 24 h, 48 h, 72 h, and 168 h post-injection). In mHSPC patients, SPECT/CT imaging was performed after cycles 1 and 2 (cumulative activity: 9 GBq) and in SGC patients only after cycle 1 (activity: 7.4 GBq). Kidney absorbed dose was calculated using organ-based dosimetry.

Results
The median kidney absorbed dose was 0.49 Gy/GBq (range: 0.34–0.66) and 0.73 Gy/GBq (range: 0.42–1.31) for [177Lu]Lu-PSMA-617 and [177Lu]Lu-PSMA-I&T, respectively (independent samples t test; P = 0.010).

Conclusion
This study shows that the kidney absorbed dose for [177Lu]Lu-PSMA-617 and [177Lu]Lu-PSMA-I&T differs, with a ~1.5x higher median kidney absorbed dose for [177Lu]Lu-PSMA-I&T. This difference in the clinical setting is considerably smaller than observed in preclinical studies and may not hamper treatments with [177Lu]Lu-PSMA-I&T.
Identification of Circular RNA Circ_0003256 as a Novel Player in Pediatric Acute Myeloid Leukemia
Authors: Liu Jing , Qiu Baihong 
Published: January 2023

Background:
Aberrant expression of circular RNAs (circRNAs) is tightly associated with the pathogenesis of human cancers, including pediatric acute myeloid leukemia (AML). In this report, we sought to define the precise action of circ_0003256 in the pathogenesis of pediatric AML.

Materials and Methods:
Circ_0003256, microRNA (miR)-582-3p, and protein kinase cAMP-activated catalytic subunit beta (PRKACB) were quantified by quantitative real-time polymerase chain reaction and Western blot. Cell proliferation, cycle distribution, and apoptosis were estimated by MTT, 5-ethynyl-2′-deoxyuridine, and flow cytometry assays, respectively. Direct relationships among circ_0003256, miR-582-3p, and PRKACB were verified by a dual-luciferase reporter and RNA pull-down assays.

Results:
Our data indicated that circ_0003256 was highly expressed in pediatric AML patients and cells. Suppression of circ_0003256 hindered cell proliferation and promoted apoptosis in THP-1 and MV4-11 cells. Mechanistically, circ_0003256 contained functional binding sites for miR-582-3p, and circ_0003256 suppression influenced cell behaviors by upregulating miR-582-3p. MiR-582-3p directly targeted and inhibited PRKACB and the inhibition of PRKACB phenocopied miR-582-3p overexpression in regulating cell functional behaviors. Moreover, circ_0003256 involved the posttranscriptional regulation of PRKACB through miR-582-3p.

Conclusion:
Our findings identify that suppression of circ_0003256 impedes the malignant behaviors of pediatric AML cells by regulating PRKACB expression by competing for shared miR-582-3p.
Timing of Central Venous Line Insertion During Induction in Children With Acute Lymphoblastic Leukemia
Authors: Ataseven Eda , Yilmaz Şebnem , Tüfekçi Özlem , Ören Hale 
Published: January 2023

Purpose:
Central venous lines (CVL) in children with acute lymphoblastic leukemia (ALL) provide comfortable administration of intensive chemotherapy and blood sampling. The optimal time for the insertion of CVL in patients with ALL during induction therapy is controversial. This study aimed to investigate the frequency of CVL-related complications in children with ALL concerning the time of CVL insertion.

Patients and Methods:
We reviewed the records of 52 pediatric ALL patients with CVL. CVL placement before or on treatment day 15 was defined as “early insertion”, and after treatment day 15 was defined as “late insertion”. Demographics, preoperative blood counts, type of central line, time of CVL placement, CVL-related complications, and blood counts during complications were all noted. All the data were collected from those with the first catheter use.

Results:
CVL was placed ≤15 days in 26 patients (50%) and after 15 days in 26 patients (50%). Regarding the infection rates, no statistical difference was found between early and late CVL-inserted groups (P=n.s.). Five patients developed thrombosis, and risk was found to be similar between early and late CVL-inserted groups (P=n.s.). Catheter-related mechanical complications were recorded in 7 patients (3 in early and 4 in late CVL-inserted group, (P=n.s.).

Conclusion:
The present study showed no relation between the timing of CVL placement during induction therapy and the occurrence of infection and thrombosis. Our results suggest that CVL can be placed safely at the time of diagnosis or early induction treatment to provide a comfortable administration of chemotherapy and decrease painful blood samplings.
Negative Schizotypy Mediates the Relationship Between Metacognition and Social Functioning in a Nonclinical Sample
Authors: Luther Lauren , Hochheiser Jesse , Wiesepape Courtney , Lysaker Paul H. 
Published: January 2023

Abstract
Reduced metacognitive abilities—difficulty making sense of and understanding oneself and others—have been found to be key predictors of social functioning across a range of clinical and nonclinical groups. However, the exact processes through which metacognition impacts social functioning are unclear. This study examined whether subclinical negative symptoms mediated the relationship between metacognition and social functioning in a nonclinical sample of young adults (n = 98). Results demonstrated that lower metacognitive mastery was found to be uniquely associated with greater subclinical negative symptoms, whereas higher subclinical negative symptoms were associated with reduced social functioning. Further, the effects of lower metacognition on reduced social function were mediated by subclinical negative symptoms and not positive or disorganized subclinical symptoms. Results suggest that subclinical negative symptoms may link reductions in metacognition with social functioning in nonclinical samples. Training aimed at enhancing metacognition may support normative social functioning in the general population.
Overall Survival With Maintenance Olaparib at a 7-Year Follow-up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial
Authors: DiSilvestro Paul , Banerjee Susana , Colombo Nicoletta , Scambia Giovanni , Kim Byoung-Gie , Oaknin Ana , Friedlander Michael , Lisyanskaya Alla , Floquet Anne , Leary Alexandra , Sonke Gabe S. , Gourley Charlie , Oza Amit , González-Martín Antonio , Aghajanian Carol , Bradley William , Mathews Cara , Liu Joyce , McNamara John , Lowe Elizabeth S. , Ah-See Mei-Lin , Moore Kathleen N. 
Published: January 2023

(Abstracted from J Clin Oncol 2022; doi: 10.1200/JCO.22.01549)
Because of nonspecific symptoms at disease presentation and inadequate screening methods, ovarian cancer is often advanced at the time of diagnosis results in a 10-year survival of 17% in patients with advanced epithelial ovarian cancer. The poly(ADP-ribose) polymerase (PARP) inhibitor olaparib is the new standard of care in patients with newly diagnosed advanced ovarian cancer and a BRCA1 and/or BRCA2 (BRCA) mutation.
Validation of a Virtual Simulator With Haptic Feedback for Endotracheal Intubation Training
Authors: Ryason Adam , Xia Zhaohui , Jackson Cullen , Wong Vanessa T. , Li Hong , De Suvranu , Jones Stephanie B. 
Published: January 2023

Introduction
Endotracheal intubation (ETI) is a procedure that varies in difficulty because of patient characteristics and clinical conditions. Existing physical simulators do not encompass these variations. The Virtual Airway Skills Trainer for Endotracheal Intubation (VAST-ETI) was developed to provide different patient characteristics and high-fidelity haptic feedback to improve training.

Methods
We demonstrate the effectiveness of VAST-ETI as a training and evaluation tool for ETI. Construct validation was evaluated by scoring the performance of experts (N = 15) and novices (N = 15) on the simulator to ensure its ability to distinguish technical proficiency. Convergent and predictive validity were evaluated by performing a learning curve study, in which a group of novices (N = 7) were trained for 2 weeks using VAST-ETI and then compared with a control group (N = 9).

Results
The VAST-ETI was able to distinguish between expert and novice based on mean simulator scores (t[88] = −6.61, P < 0.0005). When used during repeated practice, individuals demonstrated a significant increase in their score on VAST-ETI over the learning period (F[11,220] = 7206, P < 0.001); however when compared with a control group, there was not a significant interaction effect on the simulator score. There was a significant difference between the simulator-trained and control groups (t[12.85] = −2.258, P = 0.042) when tested in the operating room.

Conclusions
Our results demonstrate the effectiveness of virtual simulation with haptic feedback for assessing performance and training of ETI. The simulator was not able to differentiate performance between more experienced trainees and experts because of limits in simulator difficulty.
Towards a rapid-turnaround low-depth unbiased metagenomics sequencing workflow on the Illumina platforms
Authors: Lian Chye Winston Koh , Poh Si En , Lee Chun Kiat , Man Chan Tim Hon , Yan Gabriel , Kong Kiat Whye , Lau Lalita , Thomas Lee Wai Yip , Cheng Clark , Hoon Shawn , Seow Yiqi 
Published: January 2023

AbstractUnbiased metagenomic sequencing is conceptually well-suited for first-line infectious disease diagnostics because it does not require guesswork on the causative organism and can cover all known and unknown infectious entities other than prions. However, costs, turnaround time and human background reads in complex biofluids such as plasma stand in the way of more widespread deployment. Many protocols also require separate library preparations for DNA and RNA analytes, increasing the costs for detection. In this study, we developed a rapid unbiased metagenomics next-generation sequencing (mNGS) workflow that addresses these issues with a human background depletion kit (HostEL) and a library preparation kit that processes DNA and RNA simultaneously (AmpRE). In our analytical validation of the HostEL workflow, we were able to enrich and detect the signal from bacteria and fungi standards spiked in at physiological levels in plasma with low-depth sequencing (< 1 million reads). Our clinical validation also shows that 93% of plasma samples agreed with the clinical diagnostic test results when the diagnostic qPCR had a Ct < 33. The effect of different sequencing times was evaluated with the 19-hour iSeq 100 paired end run, a more clinically palatable simulated iSeq 100 truncated run and the rapid 7-hour MiniSeq platform. Significantly, our results demonstrate the ability to detect both DNA and RNA pathogens with low-depth sequencing. In conclusion, we demonstrate that iSeq 100 and MiniSeq platforms are compatible with unbiased low-depth metagenomics identification with the HostEL and AmpRE workflow and can be chosen based on required turnaround times.
Novel photobiomodulation therapy enhances color discrimination of color vision deficiency due to OPN1LW and/or OPN1MW gene mutations
Authors: Wang Peihong , Wang Yuqi , Jia Liang 
Published: January 2023

PurposeTo investigate the correlations of OPN1LW/OPN1MW (LW/MW) genotypes and clinical phenotypes in individuals with protan/deutan congenital color vision deficiency(CVD), and to explore photobiomodulation (PBM) therapy effects for CVD.DesignSingle-center consecutive, retrospective, observational studyParticipants43 subjects (41 males and 2 females) of protan/deutan CVD from the senior ophthalmology department of the PLA General Hospital.MethodsOpen-label, single-arm, 4-week pilot trial. Analysis of genetic, clinical, and color vision tests was performed cross-sectionally and longitudinally. Registered with the Chinese Clinical Trial Registry website (ChiCTR2200056761).Main Outcome Measurestypes of LW/MW variants, correlation of genotype and phenotype, color discrimination improvements of CVD after PBM therapy.ResultsClinically, the LW gene mutation (8 cases) causes protan CVD, the MW gene mutation (17 cases) and no definite gene mutation (10 cases) cause deutan CVD, dual mutations of LW and MW cause protan (5 cases) or deutan (3 cases) CVD. After individualized therapy, the effects of the MW gene mutation and no definite gene mutation groups are better than those of the LW gene mutation and dual mutations groups.ConclusionsFor protan/deutan CVD, PBM therapy can enhance color discrimination, and the result of gene detection is helpful to diagnose the clinical phenotype and predict the therapeutic effects of color vision correction.Financial Disclosure(s)The authors have no proprietary or commercial interest in any of the materials discussed in this article.
Medical students’ perception of resilience and of an innovative curriculum-based resilience skills building course: a participant-focused qualitative analysis
Authors: Nair Bhavana , Otaki Farah , Nair Avantika Fiza , Ho Samuel B. 
Published: January 2023

AbstractBackgroundMedicine is one of the most demanding academic fields with an extensive curriculum that entails plenty of potential stressors. There is sufficient evidence that medical students are more prone to psychological distress when compared to their peer group of other disciplines. Despite the established need to prioritize resilience skills building within the medical curriculum, very few medical programmes in the Middle East and North Africa region (MENA) proactively empower the students to help themselves in sustaining their mental health. The purpose of the current study is to explore the perception of medical students in Dubai, United Arab Emirates (UAE) regarding their understanding of, and personal experience with building resilience, and their engagement with the content of an innovative curriculum-based resilience skills building course, designed in alignment with the constructivism theory of education.MethodThe current study utilized a qualitative phenomenological research design. The curriculum-based resilience skills building course, that was investigated as part of this study, is offered at a medical school in Dubai, UAE. A total of 37 students submitted reflective essays about resilience building, in general, and the respective course, in specific. The collected data was inductively analysed following a six-step framework.FindingsThe qualitative analysis generated three interlinked themes, namely: Awareness, Application, and Appraisal.ConclusionThis study showed that integrating a resilience skills building course into medical curricula is likely to be positively appraised by the students, where it raises their level of awareness and likelihood of proactively applying the learned concepts in their daily lives. This is especially true when the course is anchored in constructivism experiential learning theory and designed to foster self-directed learning.