bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Facility Type and Volume on Treatment and Overall Survival in Craniopharyngioma
Authors: Bitner Benjamin F. , Liu Derek H. , Nottoli Madeline M. , Torabi Sina J. , Hsu Frank P.K. , Kuan Edward C. 
Published: August 2023

Abstract
Background
Craniopharyngiomas are uncommon benign sellar and parasellar tumors with high overall survival (OS) and recurrence rates. Treatment is often surgical but may include adjuvant therapies. The impact of adjuvant therapy and surgical approach have been evaluated, however, facility volume and type have not. The purpose of this study is to analyze the influence of facility volume and type on treatment modalities, extent of surgery and survival of craniopharyngioma.
Methods
The 2004–2016 National Cancer Database (NCDB) was queried for patients diagnosed with craniopharyngioma. Facilities were classified by type (academic vs. non-academic) and low- (LVC, treating < 8 patients over the timeline) versus high-volume (HVC, treating ≥ 8 patients over the timeline). Differences in treatment course, outcomes, and OS by facility type were assessed.
Results
3730 patients (51.3% female) with mean age 41.2 ± 22.0 were included with a 5-year estimated OS of 94.8% (94.0-95.5%). 2564 (68.7%) patients were treated at HVC, of which 2142 (83.5%) were treated at academic facilities. Patients treated at HVC’s were more likely to undergo both surgery and radiation. Surgical approach at HVC was more likely to be endoscopic. Patients treated at HVC demonstrated significantly higher 5-year OS compared to patients treated at LVC (96% [95% CI: 95.6–97.1% versus 91.2% [95% CI: 89-92.7%] with lower risk of mortality (Hazard ratio [95% CI] = 0.69 [0.56–0.84]).
Conclusion
Treatment of craniopharyngioma at HVC compared to LVC is associated with improved OS, lower 30- and 90-day postoperative mortality risk, and more common use of both radiotherapy and endoscopic surgical approach.
Chirality Descriptors for Structure-Activity Relationship Modeling of Bioactive Molecules
Authors: NATARAJAN RAMANATHAN , Lungu Claudiu , Basak Subhash 
Published: August 2023

Abstract
Owing to the homochirality among the α-amino acids, the building blocks, chiral environmental prevails within the structure of biological macromolecules namely, the proteins, receptors, and enzymes. This results in chiral distinction of the ligands such as drug molecules and toxicants by the biological targets. Chiral distinction of enantiomers is not only important in the biological activity of enantiomers but also in pharmacokinetics and metabolism of chemicals. The molecular descriptors that are based only on the connectivity of atoms cannot differentiate the enantiomers and diastereomers. In order to model the differential activity of enantiomers and diastereomers, molecular descriptors capable of encoding the difference in spatial arrangements of atoms and groups around a chiral center are needed. In this paper we report a modified approach that enables to compute a large pool of chirality descriptors for a given set of molecules. The new chirality descriptors can differentiate enantiomers and diastereomers. Application of the new chiral descriptors in structure-activity modelling of bioactivity of chiral molecules is illustrated for the dopamine (DA) D2 and opiate σ receptor affinities of seven pairs of enantiomers of 3-(3-hydroxyphenyl)piperidines.
Acute Post-Operative Pain Management: Practice Patterns and Treatment Challenges
Authors: Gasoma ElMuhtadi B. Y. , Mohammed Leenah M. S. 
Published: August 2023

Abstract
Background
Currently, surgical practice is thought to include postoperative pain management as a necessary component. Nevertheless, a lot of patients experience significant pain after surgery. The objective of this current survey was to evaluate the status of postoperative pain relief and to assess the types and routes of drugs administered for this purpose
Method
A questionnaire form was used to collect demographic data, type of surgery, anesthesia, and patient satisfaction. Assessment of pain severity was done during the interview using one of the following pain scales: verbal, numerical and visual. This was done 4 and 8 hours after surgery. Before leaving the hospital, patients who were discharged the same day as surgery underwent a single face-to-face interview.
Results
Of 258 patients, 34.3% experienced moderate to severe pain postoperatively at rest and 31.5 % on movement. No analgesics were prescribed to 7.1 % of the patients and of the remainder, a single analgesic was prescribed to 52.8%. Thyroid & minor abdominal surgery patients had the lowest pain intensity, especially in comparison to those undergoing thoracic and major abdominal surgery. Paracetamol and Diclofenac were the drugs most commonly prescribed (to 98.6 % and 41.4 % of patients respectively), most often on a regular schedule rather than on-demand.
Conclusion
Despite concerns, in some patient groups, analgesic usage may not be sufficient. However, our study indicates new factors that influence the severity of pain, such as analgesic drugs, anesthetic technique, and type of surgery. Awareness among professionals and the public is needed and a structured pain management program is crucial.
WITHDRAWN: GeneralSolutions with Hidden Variables to the Riccati Equation and Second-Order Linear ODEs
Authors: Zhao Ji-Xiang 
Published: August 2023

Abstract
Using suitable function transformation in combination with a specific Riccati-type equation solvable, general solution of the Riccati equation in the form of elementary quadrature is given. In the process of solving the Riccati equation, the hidden parameter and variable are discovered. This indicates that hidden parameter & variable exist in all differential equations associated with the Riccati equation, such as the second-order linear ODEs, the Schrödinger equation and the Navier–Stokes equation.
Hubungan Asupan Kalsium, Vitamin D, dan Paparan Sinar Matahari dengan Status Gizi pada Balita Usia 3-5 Tahun
Authors: Septianggreini Juli , Widyastuti Nurmasari , Ardiaria Martha , Fitranti Deny Yudi 
Published: August 2023

The purpose of the study was to analyze the relationship between calcium intake, vitamin D intake, and sun exposure with the nutritional status of children aged 3-5 years. This was an observational study with a cross-sectional design. Thirty-six subjects were selected by consecutive sampling. Nutritional status was categorized based on weight-for-height z-score (WHZ). Food intake was assessed using the semi-quantitative food frequency questionnaire, sun exposure data was determined by the sun exposure questionnaire, and physical activity was obtained through the Early Years Physical Activity Questionnaire. This study showed no significant relationship between calcium intake (p = 0.541), vitamin D intake (p = 0.267), and sun exposure (p = 0.568) with the nutritional status of children aged 3-5 years. Intake of protein, fat, fiber, and physical activity also showed no significant relationship with the nutritional status of children, whereas energy and carbohydrate intake showed a significant relationship with the nutritional status of children. This study showed no significant relationship between calcium intake, vitamin D intake, and sun exposure and the nutritional status of children aged 3-5 years. Tujuan penelitian ini adalah untuk menganalisis hubungan asupan kalsium, vitamin D dan paparan sinar matahari dengan status gizi balita usia 3-5 tahun. Penelitian ini merupakan penelitian observasional dengan desain cross-sectional. Tiga puluh enam subjek dipilih dengan consecutive sampling. Status gizi dikategorikan berdasarkan z-score berat badan menurut tinggi badan (BB/TB). Data asupan diperoleh melalui wawancara dengan instrumen Semi Quantitative Food Frequency Questionnaire. Data paparan matahari didapatkan menggunakan kuesioner paparan sinar matahari, aktivitas fisik diperoleh melalui Early Years Physical Activity Questionnaire. Data dianalisis menggunakan uji Pearson (parametrik) dan Rank-Spearman (non-parametrik). Penelitian ini menunjukkan tidak terdapat hubungan signifikan antara asupan kalsium (p=0,541), asupan vitamin D (p=0,267), dan paparan sinar matahari (p=0,568) dengan status gizi balita usia 3-5 tahun. Asupan protein, lemak, serat, dan aktivitas fisik juga menunjukkan tidak terdapat hubungan signifikan dengan status gizi balita. Sebaliknya asupan energi dan karbohidrat menunjukkan adanya hubungan signifikan dengan status gizi balita. Penelitian ini menunjukkan tidak terdapat hubungan antara asupan kalsium, asupan vitamin D dan paparan sinar matahari dengan status gizi balita usia 3-5 tahun.
Stunting dan Perkembangan Balita Usia 36-59 Bulan di Jakarta dan Papua
Authors: Sari Desi Intan , Sari Indah Purnama 
Published: August 2023

This study aims to analyze the relationship between stunting and child development of aged 36-59 months in Jakarta and Papua. This study used secondary data from the 2018 Indonesia Basic Health Survey with a cross-sectional design. The target population was mothers who have toddlers aged 0-59 months in Indonesia. The sample was mothers who have toddlers aged 36-59 months in Jakarta and Papua (335 children in Jakarta and 453 children in Papua). Samples were selected using the multistage random sampling method. This study used the Chi Square Test on bivariate analysis and the Multiple Logistic Regression Test on multivariate analysis with an alpha of 5%. The results showed that there was no significant relationship between stunting and child development in Jakarta (p=0.468). Meanwhile, the results of a study in Papua showed that there was a relationship between stunting and the development of children aged 36-59 months (PR=3.078; 95% CI=1.619-5.852) after controlling for age, sex, mother's education, environmental sanitation, and infectious disease. The recommendations in this study were increasing access to environmental sanitation and health as an effort to prevent stunting and developmental delays in children. Penelitian ini bertujuan menganalisis hubungan antara stunting dan perkembangan anak usia 36-59 bulan di Jakarta dan Papua. Penelitian ini menggunakan data sekunder Riset Kesehatan Dasar (Riskesdas) 2018 dengan desain cross-sectional. Populasi target adalah ibu yang memiliki balita usia 0-59 bulan di Indonesia. Sampel adalah ibu yang memiliki balita usia 36-59 bulan di Jakarta dan Papua dengan jumlah 335 anak di Jakarta dan 453 anak di Papua. Pemilihan sampel dengan teknik multistage random sampling. Penelitian ini menggunakan Uji Chi-Square pada analisis bivariat dan Uji Regresi Logistik Ganda pada analisis multivariat dengan alpha 5%. Hasil penelitian menunjukkan tidak ada hubungan yang signifikan antara stunting dan perkembangan anak di Jakarta (p=0,468). Sementara itu, hasil penelitian di Papua menunjukkan bahwa terdapat hubungan antara stunting dan perkembangan anak usia 36-59 bulan (PR=3,078; 95% CI=1,619-5,852). Hal itu didapatkan setelah dikontrol oleh umur, jenis kelamin, pendidikan ibu, sanitasi lingkungan, dan penyakit infeksi. Rekomendasi dalam penelitian ini yakni peningkatan akses sanitasi lingkungan dan kesehatan sebagai upaya pencegahan stunting dan keterlambatan perkembangan pada anak.
Motor rolling bearing fault diagnosis based on MVMD energy entropy and GWO-SVM
Authors: Tang Jian , Zhao Qiaoni 
Published: August 2023

For motor rolling bearing fault diagnosis, vibration signal analysis is a common method to extract sensitive fault characteristics. In this paper, a newly signal processing method, multivariate variational mode decomposition (MVMD), is proposed to extract features from motor rolling bearings. The MVMD was carried out on the motor rolling bearings state signals of different categories, and the prior parameter K value which had a great influence on the decomposition effect was analyzed. Each component obtained by decomposition was measured in the form of energy entropy (EE), and the measured feature information was classified and identified by support vector machine (SVM) classifier. Meanwhile, the grey wolf optimization (GWO) was used to optimize the parameters of the classifier network to further improve the recognition accuracy. Through the simulation results, it is found that the scheme can achieve 100 % effect on the diagnosis rate of normal working condition, outer ring fault, inner ring fault and rolling element fault under the condition of different load and speed of the motor rolling bearing.
Drinking water quality management progress in Ontario, two decades after Walkerton
Authors: Fuller Megan , Wells Emma , Furatian Laith , Douglas Ian , Lane Kaycie 
Published: August 2023

Abstract

Following the waterborne disease outbreak in Walkerton, Ontario, the province made significant efforts to implement recommendations of the public inquiry that resulted. As Ontario reformed its drinking water sector, other jurisdictions were advancing risk-based quality management frameworks for drinking water, including the World Health Organization (WHO) through its water safety plan (WSP) framework. Two decades after the Walkerton tragedy, this paper seeks to: (i) evaluate alignment of Ontario's Drinking Water Quality Management Standard (DWQMS) with the WSP framework (ii) review readily available data for evidence that Ontario's DWQMS implementation has improved drinking water safety and promoted a preventive approach through risk-based quality management. Our study found strong alignment between the Ontario DWQMS and WSP frameworks, with supporting programmes and risk assessment procedures present. Analysis of available regulatory data revealed abundant reporting of water quality and adverse incidents in municipal water systems. However, performance data were publicly available, the use of percentage scores for water quality testing obscures the details of system performance and water safety. Reports describing the DWQMS plan and audit results were difficult to obtain and not standardized. There is a need to develop mechanisms to ensure continual improvement of the DWQMS.
Hybrid model for daily streamflow and phosphorus load prediction
Authors: Lee DoYeon , Shin Jihoon , Kim TaeHo , Lee Sangchul , Kim Dongho , Park Yeonjeong , Cha YoonKyung 
Published: August 2023

Abstract

Environmental factors, such as climate change and land use changes, affect water quality drastically. To consider these, various predictive models, both process-based and data-driven, have been used. However, each model has distinct limitations. In this study, a hybrid model combining the soil and water assessment tool and the reverse time attention mechanism (SWAT–RETAIN) was proposed for predicting daily streamflow and total phosphorus (TP) load of a watershed. SWAT–RETAIN was applied to Hwangryong River, South Korea. The hybrid model uses the SWAT output as input data for the RETAIN. Spatial, meteorological, and hydrological data were collected to develop the SWAT to generate high temporal resolution data. RETAIN facilitated effective simultaneous prediction. The SWAT–RETAIN exhibited high accuracy in predicting streamflow (Nash–Sutcliffe efficiency (NSE): 0.45, root mean square error (RMSE): 27.74, percent bias (PBIAS): 22.63 for test sets), and TP load (NSE: 0.50, RMSE: 423.93, PBIAS: 22.09 for test sets). This result was evident in the performance evaluation using flow duration and load duration curves. The SWAT–RETAIN provides enhanced temporal resolution and performance, enabling the simultaneous prediction of multiple variables. It can be applied to predict various water quality variables in larger watersheds.
Pre-clinical Evidence-based Neuroprotective Potential of Naringin against
Alzheimer’s Disease-like Pathology: A Comprehensive Review
Authors: Singh Ashini , Kumar Singh Niraj 
Published: August 2023

Abstract:
Neurodegenerative disorders (NDs) are a group of progressive, chronic, and disabling
disorders that are highly prevalent and the incidence is on a constant rise globally. Alzheimer’s
disease (AD), one of the most common neurodegenerative disorders is hallmarked by cognitive
impairment, amyloid-β (Aβ) deposition, hyperphosphorylation of tau protein, cholinergic dysfunction,
mitochondrial toxicity, and neurodegeneration. Available therapeutic agents only provide
symptomatic relief and their use are limited due to serious side effects. Recent research has recognized
flavonoids as potential multi-target biomolecules that can reduce the pathogenesis of AD.
Naringin, a natural citrus flavonoid has been traditionally used to treat various NDs including AD,
and has gained special attention because exhibits a neuroprotective effect by affecting numerous
signaling pathways with minimum adverse effects. Naringin reduces deposition of Aβ, hyperphosphorylation
of tau protein, cholinergic dysfunction, oxidative stress burden, mitochondrial toxicity,
the activity of glutamate receptors, and apoptosis of the neuronal cells. Additionally, it reduces the
expression of phosphorylated-P38/P38 and the NF-κB signaling pathway, showing that a wide
range of molecular targets is involved in naringin's neuroprotective action. The present study describes
the possible pharmacological targets, signaling pathways, and molecular mechanisms of
naringin involved in neuroprotection against AD-like pathology. Based on the above pre-clinical
reports it can be concluded that naringin could be an alternative therapeutic agent for the management
of AD-like manifestation. Thus, there is a strong recommendation to perform more preclinical
and clinical studies to develop naringin as a novel molecule that could be a multi-target drug to
counteract AD.
Development of Oral Bio-banks Past, Present and Future; Challenges and
Opportunities
Authors: Hiremath Gangadhar Baniekal , Omkarbabu Kondragunta , Kokate Madhavi Hemant , Venkidasamy Baskar , Krishnan Murugesan , Murugaiyan Arun 
Published: August 2023

Abstract:
Biobank involves collecting, processing, storing, and organizing biosamples, along with
relevant personal and health information such as medical history, family records, genetics data, and
lifestyle details, for medical research and clinical care. Oral biobanking is a recently evolved field
alongside the rising of precision medicine due to recent research findings in oral oncology and other
oral complaints, namely caries and periodontal disease. The common samples in oral biobanks are matured
and primary teeth, dental pulp cells, oral biopsies, oral rinses, saliva, and swabs from the buccal
region. Moreover, biobank should not conceive of as a static collection of samples and data but as a
dynamic resource for developing novel techniques that meet current scientific demands through international
networking. However, the major bottlenecks associated with oral biobanks are privacy, processing
of samples, normalization of data, extended durability of interest markers of banked samples,
and financial sustainability of biobanks. Thus in this correspondence, we argue that an alternative approach
is urgently needed to protect the interests of many stakeholders.
Selenium, Selenoproteins and 10-year Cardiovascular Risk: Results from
the ATTICA Study
Authors: Detopoulou Paraskevi , Letsiou Sophia , Nomikos Tzortzis , Karagiannis Alexandros , Pergantis Spiros A. , Pitsavos Christos , Panagiotakos Demosthenes B. , Antonopoulou Smaragdi 
Published: August 2023

Background:
Selenium (Se) is an essential trace element that is involved in several pathophysiological
functions. The relationship of Se with cardiovascular disease remains inconclusive, especially
regarding the role of different selenospecies.

Objective:
The present study assessed the levels of Se distribution in plasma selenoproteins, namely
glutathione peroxidase 3 (GPx3), selenoprotein P (SelP) and selenoalbumin (SeAlb) and total Se in
selenoproteins in relation to 10-year cardiovascular risk in the ATTICA prospective study.

Methods:
A sub-sample from the ATTICA Study’s database, consisting of 278 subjects (114 women
and 164 men) with data on Se and selenoproteins levels, was considered. SeGPx3, SelP, and SeAlb in
human plasma were simultaneously determined by high-performance liquid chromatography (HPLC)
coupled with inductively coupled plasma mass spectrometry (ICP-MS) at baseline. The duration of the
follow-up was 8.74 ±2.36 years (mean± standard deviation) and cardiovascular outcomes were recorded.
Cox proportional hazards models were applied with total Se or selenoprotein Se as independent variables
adjusted for several covariates.

Results:
Total Se in selenoproteins was positively related to 10-year relative risk of cardiovascular disease
(Hazard Ratios of 3rd vs 2nd tertile 10.02, 95% CI:1.15, 92.34). Subjects with high Se but low
SeGPx3, as identified by discordant percentiles in the distribution of SeGPx3 and Se, had a higher cardiovascular
risk.

Conclusions:
The differentiated effects of circulating selenoproteins on cardiovascular disease risk in the
present study, suggest the importance of redox regulation by specific selenoproteins.
Review on Pyrazole Hybrids as Anti-microbial Agents
Authors: Goel Tanvi , Jain Naman , Bansode Deepali 
Published: August 2023

Abstract:
A five-membered heteroaromatic ring with two nitrogen atoms, pyrazole, is of immense
significance. Pyrazole and its derivatives are well-known nitrogen-containing heterocyclic compounds
that are significant in medicinal chemistry and have a variety of biological properties, according to a
thorough analysis of this class of heterocyclic lead. This article summarises some biologically active,
potent pyrazole hybrids and their structure-activity relationship for antimicrobial activity published by
various researchers across the world. It is divided into two sections. The first part summarizes recent
developments in pyrazole derivatives for various biological activities, such as anti-Alzheimer’s, antioxidant,
anticancer, anti-inflammatory, and antiviral, while the second section focuses on a detailed
substitution analysis of pyrazole with its hybrid, which is the structure-activity relationship needed for
antimicrobial activity. The presence of pharmacological potential of pyrazole moiety has been demonstrated
by the role of a nucleus in pharmacological agents from different therapeutic groups, such as
the potent anti-inflammatory agent celecoxib, anti-obesity drug rimonabant, analgesic diphenamizole,
H2-receptor agonist betazole, and antidepressant agent fezolamide. The design of new pyrazole derivatives
has become an interesting research area due to their versatile nature and biological significance.
Moreover, it has been observed that pyrazole in combination with another moiety has a strong potent
antimicrobial effect.