bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Tumor Necrosis Factor–α Inhibitors in the Treatment and Occurrence of Acne
Authors: Sandoval Aaron Gabriel W. , Vaughn Lauren T. , Huang Jennifer T. , Barbieri John S. 
Published: March 2023

ImportanceTumor necrosis factor–α inhibitors (TNFis) approved to treat several inflammatory diseases are sometimes used off label to treat severe forms of acne that are refractory to conventional therapies. However, use of TNFis can also be followed by acne occurrence, suggesting an association between TNFis and acne. Most of the literature on the topic comprises case reports and series that have not been reviewed in a systematic manner.ObjectiveTo characterize the demographic characteristics, clinical presentations, treatments, and outcomes of patients receiving TNFis to treat acne and patients who develop acne following treatment of other conditions with TNFis.Evidence ReviewA systematic literature review was performed and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guidelines. PubMed and Web of Science were searched from inception through October 17, 2022. Included studies reported on patients of any sex or age who received TNFis whose treatment was followed by resolution or occurrence of acne. Two independent reviewers screened studies based on predefined criteria and extracted data from each study, which were quantitatively combined.FindingsA total of 53 studies reporting on 64 patients who received TNFis for the treatment of acne (n = 47) or who experienced acne after treatment with TNFis for a different condition (n = 17) (mean age, 28.7 years; range, 12-64 years; 6 female individuals [8.8%]) were included. The TNFis used included adalimumab, infliximab, and etanercept. Among the 47 patients treated for acne with TNFis, most had previously received antibiotics (31 [66.0%]) or isotretinoin (32 [68.1%]). Most (44 [93.6%]) experienced partial improvement (25 [53.2%]) or clearance (19 [40.4%]) with very few adverse effects reported (3 [6.4%]). Acne manifested as part of an inflammatory syndrome for 30 patients (63.8%). Among the 17 patients treated TNFis for a different condition followed by the occurrence of acne, only 1 patient (5.9%) reported having a history of acne. Therapy with TNFis was either discontinued (8 [47.1%]) or altered (6 [35.3%]) in most patients due to acne occurrence, typically with improvement in symptoms.Conclusions and RelevanceThe results of this systematic review suggest that TNFis can be effective in treating refractory acne but can also be associated with the occurrence of acne in certain instances. Further studies elucidating the role that TNF plays in treating and inducing acne could yield insight into off-label TNFi use and acne pathogenesis, potentially guiding clinical care of patients with acne treated or induced by TNFis.
A Dual‐Mode Electrochromic Platform Integrating Zinc Anode‐Based and Rocking‐Chair Electrochromic Devices
Authors: Zhang Wu , Li Haizeng , Elezzabi Abdulhakem Y. 
Published: March 2023

AbstractThe complementary electrochromic device, where the optical transmittance changes upon the flow of cations back and forth between anodic and cathodic electrodes, operates in a rocking‐chair fashion if it can inherently self‐discharge. Herein, the first demonstration of a dual‐mode electrochromic platform having self‐coloring and self‐bleaching characteristics is reported, which is realized by sandwiching zinc metal within a newly‐designed Prussian blue (PB)‐WO3 rocking‐chair type electrochromic device. It is demonstrated that the redox potential differences between the zinc metal and the WO3/PB electrodes endow the self‐color‐switching of these electrodes. By employing a hybrid electrolyte of Zn2+/K+, it is further shown that the colored PB‐WO3 rocking‐chair device is capable of spontaneously bleaching when the anodic and cathodic electrodes are coupled. This dual‐mode light‐control strategy enables the electrochromic devices to exhibit four distinct optical states with the highest optical contrast of 72.6% and fast switching times (<5 s for the bleaching/coloration processes). Furthermore, the built‐in voltage of the dual‐mode electrochromic devices not only promotes energy efficiency, but also augments the bistability of the devices. It is envisioned that the broad implication of the present platform is in the development of self‐powered smart windows, colorful displays, optoelectronic switches, and optical sensors.
Manipulating Ionic Behavior with Bifunctional Additives for Efficient Sky‐Blue Perovskite Light‐Emitting Diodes
Authors: Zhou Wei , Shen Yang , Cao Long‐Xue , Lu Yu , Tang Ying‐Yi , Zhang Kai , Ren Hao , Xie Feng‐Ming , Li Yan‐Qing , Tang Jian‐Xin 
Published: March 2023

AbstractPerovskite Light‐emitting diodes (PeLEDs) have emerged as a promising technique for future high‐definition displays due to their outstanding electroluminescent characters. However, the development of blue PeLEDs toward practical applications is seriously hindered by their inferior performance, which mainly arises from the detrimental halide ionic behavior and thus severe nonradiative recombination in mixed‐halide blue perovskite materials. Herein, efficient sky‐blue PeLEDs featuring spectrally stable emission at 483 nm are realized by employing bifunctional passivators of Lewis‐base benzoic acid anions and alkali metal cations to simultaneously passivate the under‐coordinated lead atoms and suppress halide ion migration. A decent external quantum efficiency (EQE) of 16.58% and a maximum EQE of 18.65% are achieved, which is further boosted to 28.82% through the optical outcoupling enhancement. This work demonstrates unique insight into the generality and individuality of this category of benzoates and puts forward a feasible guidance in choosing appropriate additives for efficient perovskite materials.
In‐Depth Occlusion of Dentinal Tubules and Rapid Remineralization of Demineralized Dentin Induced by Polyelectrolyte‐Calcium Complexes
Authors: Zhou Zihuai , Li Jiachen , Wang Zhe , Zhang Hongli , Wang Yiru , Shen Dongni , Wu Zhifang , Shen Minjuan , Pan Haihua , Wang Qi , Tang Ruikang , Hannig Matthias , Fu Baiping 
Published: March 2023

AbstractDentin hypersensitivity (DH) is triggered by external stimuli irking fluid flow through exposed dentinal tubules (DTs). Three commercially available desensitizing agents as control in this study only achieve limited occlusion depths of ≈10 µm in the DTs as well as scarce remineralization of demineralized dentin matrix. Herein, polyelectrolyte‐calcium complexes pre‐precursor (PCCP) process is proposed for managing DH that demineralized dentin with exposed DTs is rubbed with ultrahighly concentrated polyelectrolyte‐calcium suspension (4 g L−1‐5.44 m) followed by phosphate solution (3.25 m), each 10 min, leading to heavy remineralization of demineralized dentin and compact occlusion of the DTs over 200 µm after 1 day of in vitro and in vivo incubation. For the first time, it is demonstrated that the PCCP process relies on the pH‐dependent electrostatic attraction between electropositive polyelectrolyte‐calcium complexes and electronegative inwalls of DTs comprised of collagen fibrils and hydroxyapatite crystals under alkaline condition. The PCCP process might shed light on a promising dentin desensitizing strategy for DH management via rapid in‐depth DT occlusion and remineralization of demineralized dentin.
Influence of Water Content on Speciation and Phase Formation in Zr–Porphyrin‐Based MOFs
Authors: Koschnick Charlotte , Terban Maxwell W. , Canossa Stefano , Etter Martin , Dinnebier Robert E. , Lotsch Bettina V. 
Published: March 2023

AbstractControlled synthesis of phase‐pure metal–organic frameworks (MOFs) is essential for their application in technological areas such as catalysis or gas sorption. Yet, knowledge of their phase formation and growth remain rather limited, particularly with respect to species such as water whose vital role in MOF synthesis is often neglected. As a consequence, synthetic protocols often lack reproducibility when multiple MOFs can form from the same metal source and linker, and phase mixtures are obtained with little or no control over their composition. In this work, the role of water in the formation of the Zr–porphyrin MOF disordered PCN‐224 (dPCN‐224) is investigated. Through X‐ray total scattering and scanning electron microscopy, it is observed that dPCN‐224 forms via a metal–organic intermediate that consists of Zr6O4(OH)4 clusters linked by tetrakis(4‐carboxy‐phenyl)porphyrin molecules. Importantly, water is not only essential to the formation of Zr6O4(OH)4 clusters, but it also plays a primary role in dictating the formation kinetics of dPCN‐224. This multidisciplinary approach to studying the speciation of dPCN‐224 provides a blueprint for how Zr‐MOF synthesis protocols can be assessed and their reproducibility increased, and highlights the importance of understanding the role of water as a decisive component in Zr‐MOF formation.
Trans‐Reflective Structural Color Filters Assisting Multifunctional‐Integrated Semitransparent Photovoltaic Window
Authors: Liang Ningning , Tian Ruiqi , Xu Ye , Yao Huifeng , Yang Hua , Wei Yi , Xin Xia , Chen Ruixiang , Zhai Tianrui , Wang Zhaohui , Hou Jianhui 
Published: March 2023

AbstractMultifunction‐integrated semitransparent organic photovoltaic cells (STOPVs), with high power generation, colorful transmittance/reflectance, excellent ultraviolet (UV) protection, and thermal insulation, are fully in line with the concept of architectural aesthetics and photoprotection characteristics for building‐integrated photovoltaic‐window. For the indelible rainbow color photovoltaic window, one crucial issue is to realize the integration of these photons‐ and photoelectric‐related multifunction. Herein, dynamic transmissive and reflective structural color controllable filters, with asymmetrical metal‐insulator‐metal (MIM) configurations (20 nm‐Ag‐HATCN‐30 nm‐Ag) through machine learning, are deliberately designed for colorful STOPV devices. This endows the resultant integrated devices with ≈5% enhanced power conversion efficiency (PCE) than the bare‐STOPVs, gifted UV (300–400 nm) blocking rates as high as 93.5, 94.1, 90.2, and 94.5%, as well as a superior infrared radiation (IR) (700‐1400 nm) rejection approaching 100% for transparent purple‐, blue‐, green‐ and red‐STOPV cells, respectively. Most importantly, benefiting from the photonic recycling effect beyond microcavity resonance wavelength, a reported quantum utilization efficiency (QUE) as high as 80%, is first presented for the transparent‐green‐STOPVs with an ultra‐narrow bandgap of 1.2 eV. These asymmetrical Febry‐Pérot transmissive and reflective structural color filters can also be extended to silicon‐ and perovskite‐based optoelectric devices and make it possible to integrate additional target optical functions for multi‐purpose optoelectric devices.
Target‐Driven Design of Deep‐UV Nonlinear Optical Materials via Interpretable Machine Learning
Authors: Wu Mengfan , Tikhonov Evgenii , Tudi Abudukadi , Kruglov Ivan , Hou Xueling , Xie Congwei , Pan Shilie , Yang Zhihua 
Published: March 2023

AbstractThe development of a data‐driven science paradigm is greatly revolutionizing the process of materials discovery. Particularly, exploring novel nonlinear optical (NLO) materials with the birefringent phase‐matching ability to deep‐ultraviolet (UV) region is of vital significance for the field of laser technologies. Herein, a target‐driven materials design framework combining high‐throughput calculations (HTC), crystal structure prediction, and interpretable machine learning (ML) is proposed to accelerate the discovery of deep‐UV NLO materials. Using a dataset generated from HTC, an ML regression model for predicting birefringence is developed for the first time, which exhibits a possibility of achieving fast and accurate prediction. Essentially, crystal structures are adopted as the only known input of this model to establish a close structure‐property relationship mapping birefringence. Utilizing the ML‐predicted birefringence which can affect the shortest phase‐matching wavelength, a full list of potential chemical compositions based on an efficient screening strategy is identified. Further, eight structures with good stability are discovered to show potential applications in the deep‐UV region, owing to their promising NLO‐related properties. This study provides a new insight into the discovery of NLO materials and this design framework can identify desired materials with high performances in the broad chemical space at a low computational cost.
Reversible Thermochromic Bismuth Iodide Enabled by Self‐Adjustment
Authors: Wen Rui , Wang Yanyan , Ma Xinjie , Yan Yikun , Ma Qi , Gao Jinpeng , Sun Huaming , Huang Hao , Gao Ziwei 
Published: March 2023

AbstractLight‐harvesting materials with dynamical management of light transmittance hold great promise in smart photovoltaics (PV). Here, a novel organic–inorganic halide, MVBi2I8 (MV = methyl viologen cation), exhibiting reversible thermochromism and constant bandgap of ≈1.65 eV over a wide temperature range of 77–453 K, is presented as a candidate. The compound consists of 0D (Bi4I16)4– clusters and MV2+ cations. And the adjacent (Bi4I16)4– clusters are in touch with each other, forming a 3D interaction for the inorganic part. The experimental and theoretical studies reveal that the ionic and covalent interactions in the crystal undergo a self‐adjusting process in response to temperature changes. The self‐adjustment and electron transfer between inorganic clusters and organic cations enable excellent reversible thermochromism and constant narrow bandgaps over a wide temperature range, which is expected for smart PV windows integrated with information displays and potentially other technologies.
Mg–B–Reduced Graphene Oxide Nanocomposites with Negligible Incubation Time for Hydrogen Release
Authors: Satya Aditya Marla V. V. , Panda Srikanta , Kutiyar Sanket , Tatiparti Sankara Sarma V. 
Published: March 2023

AbstractDepleting fossil fuels and greenhouse emissions render hydrogen (H) a promising alternative for powering automobiles. MgH2 with its promising H‐weight capacity ≈7.6 wt% can be used for this purpose. However, it exhibits long incubation times with no significant H‐release during the early stages. The present Mg–B–reduced graphene oxide (rGO) nanocomposites can reduce such incubation time drastically. Herein, Mg, rGO, and elemental B as a light weight catalyst at various proportions (viz. B/C (from rGO) weight ratios of 0, 0.09, 0.22, 0.36, and 0.90) are used to synthesize Mg–B–rGO nanocomposites by ball milling. They are eventually subjected to hydrogen uptake at ≈320 °C and PH2 ≈ 15 bar followed by H‐release in vacuum. The nanocomposite with B/C ≈ 0.22 exhibits remarkably negligible incubation time (≈43 s) vis‐à‐vis ≈11 min by B/C = 0. This B/C ≈ 0.22 nanocomposite experiences charge (electron) transfer from Mg and B to C, located external to MgH2 unit cell. This causes Mg←H→B “Tug‐of‐war” within MgH2 unit cell, containing B in its interstitials (due to ball milling) and shrinking it. This leads to “structural catalysis” of H‐release, understood by X‐ray photoelectron, valence band, Raman spectra, and novel electron density maps. These novel materials can alleviate the need for activation cycles for their application.
Polyphotosensitizer‐Based Nanoparticles with Michael Addition Acceptors Inhibiting GST Activity and Cisplatin Deactivation for Enhanced Chemotherapy and Photodynamic Immunotherapy
Authors: Zhao Qinxin , Liang Ganghao , Guo Boda , Wang Wenkuan , Yang Chao , Chen Dong , Yang Feiya , Xiao Haihua , Xing Nianzeng 
Published: March 2023

AbstractGlutathione S‐transferase (GST), which is a key enzyme in the conjugation reaction of glutathione (GSH), is overexpressed in cancer cells, leading to cisplatin deactivation and ultimately drug resistance. In addition, many tumors are immune “cold tumors,” limiting the application of immune checkpoint inhibitors. Herein, a reactive oxygen species (ROS)‐responsive polyphotosensitizer‐based nanoparticle (NP2) with Michael addition acceptors inhibiting GST activity and cisplatin deactivation is designed. Under the 808 nm light irradiation, on the one hand, the Michael addition acceptor in NP2 can react with GST and inhibit its activity, thereby decreasing the GSH conjugation and reducing the GSH‐mediated deactivation of cisplatin and improving its chemotherapeutic effect. On the other hand, NP2+L induces more ROS production in prostate tumor cells, which can further induce type II immunogenic cell death (ICD) and stimulate a stronger antitumor immune response. It is found that NP2 under the 808 nm light irradiation (NP2+L) can increase PD‐L1 expression on the surface of prostate cancer cells. Subsequently, NP2+L combined with PD‐L1 treatment is found to simultaneously enhance the efficacies of chemotherapy and photodynamic immunotherapy in prostate tumors, providing a new paradigm for the clinical multimodal treatment of tumors.
Long‐term outcomes in ALG13‐Congenital Disorder of Glycosylation
Authors: Shah Rameen , Johnsen Christin , Pletcher Beth A. , Edmondson Andrew C. , Kozicz Tamas , Morava Eva 
Published: March 2023

AbstractALG13‐CDG is a rare X‐linked disorder of N‐linked glycosylation. Given the lack of long‐term outcome data in ALG13‐CDG, we collected natural history data and reviewed individuals surviving to young adulthood with confirmed pathogenic variants in ALG13 in our own cohort and in the literature. From the 14 ALG13‐CDG patients enrolled into our Frontiers of Congenital Disorders of Glycosylation Consortium natural history study only two patients were older than 16 years; one of these two females is so far unreported. From the 52 patients described in the medical literature with confirmed pathogenic variants in ALG13 only five patients were older than 16 years (all females), in addition to the new, unreported patient from our natural history study. Two male patients have died due to ALG13‐CDG, and there were no surviving males older than 16 years with a confirmed ALG13‐CDG diagnosis. Our adolescent and young adult cohort of six patients presented with epilepsy, muscular hypotonia, speech, and developmental delay. Intellectual disability was present in all female patients with ALG13‐CDG. Unreported features included ataxia, neuropathy, and severe gastrointestinal symptoms requiring G/J tube placement. In addition, two patients from our natural history study developed unilateral hearing loss. Skeletal abnormalities were found in four patients, including osteopenia and scoliosis. Major health problems included persistent seizures in three patients. Ketogenic diet was efficient for seizures in three out of four patients. Although all patients were mobile, they all had severe communication problems with mostly absent speech and were unable to function without parental support. In summary, long‐term outcome in ALG13‐CDG includes gastrointestinal and skeletal involvement in addition to a chronic, mostly non‐progressive neurologic phenotype.
Assessing the distribution of mayflies (Ephemeroptera: Insecta) in the Brazilian Amazon to guide more effective conservation
Authors: Cardoso Mylena Neves , Shimano Yulie , Cruz Paulo Vilela , Boldrini Rafael , Mariano Rodolfo , Nessimian Jorge Luiz , Molineri Carlos , Salles Frederico Falcão , de Andrade André Felipe Alves , De Marco Paulo , Juen Leandro 
Published: March 2023

Abstract

Environmental changes are increasingly frequent, resulting in adverse impacts on biodiversity. These effects are more harmful when superimposed on areas of high biodiversity such as the Amazon region, in which the gaps in knowledge of the number of existing species and how they are distributed.
This article reviews the known geographical distributions of Ephemeroptera in the Brazilian Amazon based on the current uneven sampling effort to identify which species and biodiversity hotspots are poorly protected, and where more work is required to address the conservation needs of this group.
A sampling effort index was created to identify which areas have the highest potential mayfly richness and the greatest concentration of knowledge gaps. The mayfly records were combined with environmental variables to generate predictive models of the areas suitable for mayflies using species distribution modelling, and species that lack protection in conservation units and indigenous territories were indicated as priorities for future inventories. Caenis pflugfelderi, Microphlebia surinamensis, Tricorythopsis pseudogibbus and Tricorythodes sp. nov. were identified as threatened in the Brazilian Amazon given that they were recorded in an unprotected area of intense land use with a restricted potential distribution.
Mayflies have been recorded in only 5% of the Brazilian Amazon biome. The model indicated a greater diversity in the northern and north‐eastern Amazon. The sampling effort index indicated a total area of 46,225 km2 in mayfly biodiversity not protected by conservation units or indigenous territories.
This study raises awareness of the importance of intensifying studies of Ephemeroptera in the Brazilian Amazon, and demonstrates that the conservation units or indigenous territories do not protect many species.
Modifizierte Prüfverfahren zur baustellengerechten Bestimmung der Klebrigkeit von Frischbetonen
Authors: Weiß Maximilian , Przondziono Robin , Breitenbücher Rolf 
Published: March 2023

AbstractFür die Bewertung der Verarbeitbarkeit von Frischbetonen ist die gängige Konsistenzprüfung (Ausbreitmaß, Verdichtungsmaß) in den meisten Fällen ausreichend. In bestimmten Fällen, z. B. bei einer anschließenden Oberflächenbearbeitung (Flügelglätten), zeigte sich in der Praxis vielfach, dass Frischbetone mit bestimmten PCE‐Fließmitteln klebriger sind als andere, wodurch die Bearbeitung der Oberfläche durch maschinelles Flügelglätten erheblich erschwert werden kann. Demzufolge wäre es hilfreich, wenn bereits bei der Frischbetonprüfung auf der Baustelle weitergehende quantitative Informationen zur Klebrigkeit des Frischbetons generiert werden könnten. Im Rahmen umfangreicher Versuchsreihen wurden zur praxisgerechten Erfassung der dafür relevanten rheologischen Eigenschaften der Frischbetone zum einen der konventionelle Ausbreitversuch modifiziert (gestuftes Ausbreitmaß) und zum anderen ein Kugeleinsinkversuch weiterentwickelt.
Fuel‐dependent, shape‐selective, distinct blue and green photoluminescence from α‐Bi2O3 and β‐Bi2O3 synthesised using microwave combustion
Authors: Bashir Aamir , Mestry Sriraj S. , Vashishtha Pargam , Gupta Govind , Bhaduri Gaurav A. 
Published: March 2023

AbstractIn the current study, α‐Bi2O3 and β‐Bi2O3 were synthesised using a one‐step, novel, solid–solid combustion technique. The reaction rate was increased with the use of microwaves (molecular heating) compared to direct or indirect heating. A strong relationship was observed between the fuel, polymorphic structure, shape and optical properties of the synthesised Bi2O3. Photoluminescence studies reveal that two major visible emissions are observed for all samples. The two emissions are distinct with a broad peak in blue and a narrow peak in green. The intensity of the green characteristic emission depends strongly on the heating method used for synthesis and is more intense for microwave‐synthesised samples.