bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid Processing of Uniform, Thin, Robust, and Large‐Area Garnet Solid Electrolyte by Atmospheric Plasma Spraying
Authors: Wu Yulong , Wang Kuangyu , Liu Kai , Long Yuanzheng , Yang Cheng , Zhang Haitian , Pan Wei , Si Wenjie , Wu Hui 
Published: June 2023

AbstractAll‐solid‐state batteries (ASSBs) are rapidly moving toward commercialization as a promising high‐performance energy storage device for portable electronics and electric vehicles. One of the most challenging problems hindering the industrialization of ASSBs is the lack of technologies for cost‐effective and large‐scale manufacturing of high‐quality solid‐state electrolytes (SSEs) with about the same thickness as the polymer separators in conventional lithium‐ion batteries. Herein, atmospheric plasma spraying (APS) is adopted as a practical route to process large‐scale, uniform, and thin SSEs to conduct Li‐ions and further to manufacture ASSBs. Garnet‐type Li7La3Zr2O12 (LLZO) films with thicknesses ranging from 30 to 300 µm are successfully manufactured with direct APS technique followed with a post annealing treatment. The electrolyte reaches a high Li‐ion conductivity of 3.82 × 10−5 S cm−1 at room temperature (25 °C). Additionally, the LLZO film with a thickness of 300 µm shows a flexural strength of 157 MPa. Li/LLZO/Li and Li/LLZO/LiFePO4 cells are assembled with the films, both showing stable cycling performance. The APS method shows scalability in solid‐state electrolyte film production, and most importantly, such a process is highly compatible with the current battery industry.
Visible‐Light‐Induced Synthesis of Thioethers through Three‐Component Reactions of α‐Diazoesters, Thiols, and Cyclic Ethers
Authors: Lv Yufen , Wang Zhiwei , Hao Jindong , Zhao Xiaohui , Wei Wei 
Published: June 2023

AbstractThioethers are important sulfur‐containing compounds that have widespread application in organic synthesis, medicinal chemistry and materials science. Herein, a visible‐light‐mediated three‐component reaction of α‐diazoester, thiol, and cyclic ether leading to thioether has been developed at room temperature. Through this methodology, a variety of three‐component coupling products with the introduction of the ring‐opening of ether could be efficiently assembled under photocatalyst‐ and additive‐free conditions.
Combating loneliness: The role of neighbourhood ICT, environmental attractiveness, and a sense of belonging to a local community
Authors: Latikka Rita , Savela Nina , Rubio‐Hernández Rosana , Koivula Aki , Makkonen Jouko , Nieto Fernández Fernando , Väänänen Kaisa , Oksanen Atte 
Published: June 2023

AbstractNeighbourhoods can provide a sense of belonging to a local community and support subjective well‐being. Our goal was to gain novel insight into the value of neighbourhood information and communication technology (ICT) in combating loneliness. Furthermore, we were interested in how a sense of belonging to a local community can be a potential mediating factor and the role of environmental attractiveness. We used data from a nationwide survey of Finnish respondents (N = 1,226) and structural equation modelling for data analysis. We found that perceived environmental attractiveness and a sense of belonging to a local community were negatively associated with loneliness, while the use of neighbourhood ICT was positively associated with loneliness. Perceived environmental attractiveness and use of neighbourhood ICT were positively associated with a sense of belonging to a local community. Perceived environmental attractiveness and use of neighbourhood ICT were negatively associated with loneliness via a sense of belonging to a local community. Our results suggest that perceived environmental attractiveness and use of neighbourhood ICT could help reduce loneliness by enhancing a sense of belonging to a local community. Interventions aimed at improving perceived environmental attractiveness and individuals' senses of belonging to a local community could be particularly helpful in combating loneliness. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
An overview of the consumer‐centric disruptive technology research: Insights from topic modelling and literature review
Authors: Beheshti Moein , ZareRavasan Ahad , Mahdiraji Hannan Amoozad , Jafari‐Sadeghi Vahid , Sakka Georgia 
Published: June 2023

AbstractThis review aims to assess the most prevalent disruptive technologies of the past decade and evaluate them from a dual perspective. This study utilises the technology life cycle framework to classify disruptive technologies into three phases, (i) emerging, (ii) industry, and (iii) customer‐focused research outcomes. Subsequently, entities using six thematic categories via topic modelling are assessed to determine the research trajectory about customers, industries, and theory. The present study utilises the Latent Dirichlet Allocation framework for topic modelling, a quantitative tool that employs advanced statistical methodology to extract semantic knowledge from large text corpora. This approach offers a more comprehensive and insightful categorisation of information compared to traditional research review models such as archive review, meta‐review analysis, and systematic literature review. After the review, over 750 articles were analysed and classified according to their unique themes and technological emphasis. The study suggests practical applications that could enhance industrial progress through disruptive technology. Furthermore, by identifying gaps, the authors suggest multiple research prospects for forthcoming investigations on disruptive technologies and their impact on consumer behaviour. This research is novel in various aspects. This research is by far the only research record in the last decade that provides a systematic literature review of disruptive technologies with an extensive focus on customers. Considering the methodological perspective, this research uses topic modelling as a new literature review model, enabling analysing more research outputs and yielding more valuable findings than traditional methodologies.
Small Molecule AIEgens for Illuminating Sub‐Cellular Endoplasmic Reticulum, Mitochondria, and Lysosomes**
Authors: Ingle Jaypalsing , Das Bibhas , Chaudhary Keshav , Mondal Anirban , Basu Sudipta 
Published: June 2023

AbstractOrganelles are the working hubs of the cells. Hence, visualizing these organelles inside the cells is highly important for understanding their roles in pathological states and development of therapeutic strategies. Herein, we report the development of a novel highly substituted oxazoles with modular scaffolds (AIE‐ER, AIE‐Mito, and AIE‐Lyso), which can home into endoplasmic reticulum (ER), mitochondria, and lysosomes inside the cells. These oxazoles showed remarkable aggregation‐induced emission (AIE) property in water and in the solid state due to dual intramolecular H‐bonding, which was confirmed by pH‐ and temperature‐dependent fluorescence studies followed by molecular dynamics (MD) simulations and density functional theory (DFT) calculations. Confocal laser scanning microscopy studies revealed that AIE‐ER, AIE‐Mito, and AIE‐Lyso efficiently homed into ER, mitochondria and lysosomes, respectively, in the HeLa cervical cancer cells and non‐cancerous human retinal pigment epithelial RPE‐1 cells within 3 h without showing any toxicity to the cells with high sub‐cellular photostability. To the best of our knowledge, this is the first report of highly substituted oxazole‐based small molecule AIEgens for organelle imaging. We anticipate these novel AIEgens have promise to image sub‐cellular organelles in different diseased states as well as understanding the inter‐organelle interactions towards the development of novel therapeutics.
Controlling the Reactivity and Interactions between Hydrogen and Palladium Nanoparticles via Management of the Particle Diameter
Authors: Moumaneix Lilian , Rautakorpi Akseli , Kallio Tanja 
Published: June 2023

AbstractTailoring the interactions between hydrogen and palladium is crucial for numerous industrial and research applications. The fine control of Pd nanoparticles (NPs) diameter is promising to address this problem when other means, i. e. temperature, pressure, or cell voltage, are set by the ongoing process. We investigate the electrochemical behaviour of Pd NPs in the presence of hydrogen over a large range of particle diameters, between 3.8–21.5 nm. The study is carried out in both a three‐electrode setup and a proton pump. A linear relationship between the H/Pd ratios and the NPs diameter is evidenced. The increase in particle size is accompanied by an extension of the loading duration to reach a stable hydride. Beyond H absorption, the HER and HOR kinetics are examined as a function of the particle diameter. The smaller the particle the higher the catalytic activity, with exchange currents ranging between approx. 1.7–9.8 mA mgPd−1.
KFe(C2O4)F: A Fluoro‐oxalate Cathode Material for Li/Na‐Ion Batteries
Authors: Pramanik Atin , Manche Alexis G. , Smeaton Megan T. , Sougrati Moulay‐Tahar , Lightfoot Philip , Armstrong Anthony Robert 
Published: June 2023

AbstractThe iron‐based polyanionic fluoro‐oxalate material, KFe(C2O4)F (KFCF), has been synthesized by hydrothermal methods. This compound shows promising reversible lithium and sodium insertion properties as a cathode material. The material delivered a first‐cycle discharge capacity of 120 mAh g−1 at ∼3.3 V (Li+/Li) and 97.4 mAh g−1 at ∼3.0 V (Na+/Na) in LIB and NIB, respectively. Stable cycling performance was observed in both cases. The involvement of reversible Fe2+/Fe3+ redox was confirmed by ex‐situ Mössbauer spectroscopy supported by first‐principles calculations. This study reveals promising performance from a mixed oxalate‐fluoride based polyanionic material thereby opening up further possibilities for materials discovery in the design of new electrode materials.
Mechanistic Aspects of the Crabtree‐Pfaltz Hydrogenation of Olefins ‐ An Interplay of Experimentation and Quantum Chemical Computation
Authors: Helmchen Günter 
Published: June 2023

AbstractIntroduction of Crabtree's iridium‐based hydrogenation catalyst in 1977 marked a paradigm shift both with respect to the role of iridium in homogeneous catalysis as well as catalytic hydrogenation of olefins. In 1998, Pfaltz introduced an improved catalyst, by use of BARF− as anion, and established the first chiral variant of the Crabtree catalyst. This led to numerous practical highly enantioselective syntheses. Elucidation of mechanistic details posed great problems because of instability of the crucial intermediates. A remarkable breakthrough was achieved by Brandt, Andersson et al. in 2003, based on dft calculations. These authors replaced a previously assumed IrI/IrIII catalytic cycle by a novel IrIII/IrV cycle. The proposal was experimentally verified by Pfaltz in 2014 and corroborated by advanced quantum chemical calculations. This essay is an attempt to describe a fascinating interplay of experiments and quantum chemical calculations for an important synthetic method.
Evaluating the performance of anal cytology and high‐risk HPV genotyping for detecting anal HSIL in a clinic‐based sample of people living with and without HIV in Puerto Rico
Authors: Ramos‐Cartagena Jeslie M. , Keller Kandyce , Guiot Humberto M. , Muñoz Cristina , Colón‐López Vivian , Deshmukh Ashish A. , Suárez Erick L. , Tirado‐Gómez Maribel , Ortiz Ana P. 
Published: June 2023

AbstractBackgroundGiven the disproportionately elevated anal cancer risk in high‐risk populations, it is important to assess the performance of commonly used anal cancer screening tools to improve the effectiveness of detection and treatment methods. This study evaluates 1) the concordance between anal cytology and histology results and 2) the performance of cytology and high‐risk human papillomavirus (HR‐HPV) genotyping as screening tools for detecting histologically confirmed anal high‐grade squamous intraepithelial lesions (HSIL).MethodsData from the Anal Neoplasia Clinic in Puerto Rico (2014–2021; n = 466) was used. The clinical performance of anal cytology and HR‐HPV genotyping to detect HSIL was compared to the gold standard: high‐resolution anoscopy‐guided biopsy. Sensitivity, specificity, positive predictive value, negative predictive value, and κ coefficients were calculated.ResultsA total of 66.95% of the patients were men, 74.0% were people living with HIV, 76.2% had anal HR‐HPV infection, and 40.34% had histologically confirmed anal HSIL. The weighted κ statistic between the tests (cytology and histology) was 0.25 (p < .001). The sensitivity and specificity of cytology alone to detect anal HSIL were 84.3% (95% confidence interval [CI], 78.3%–89.1%) and 36.0% (95% CI, 30.3%–42.0%), respectively. Anal HR‐HPV genotyping had higher sensitivity (92.2%; 95% CI, 87.4%–95.6%) and similar specificity (34.8%; 95% CI, 29.2%–40.7%) compared to cytology. The two tests combined (positive results following cytology or HR‐HPV test) improved sensitivity to detect anal HSIL (97.9%; 95% CI, 94.8%–99.4%), but specificity was compromised (19.2%; 95% CI, 14.7%–24.4%).ConclusionAlthough HR‐HPV genotyping improved the detection of anal HSIL, HR‐HPV testing had lower specificity than anal cytology alone.
Protocol Considerations for In Vitro Metabolic Glycoengineering of Non‐Natural Glycans
Authors: Dammen‐Brower Kris , Tan Elaine , Almaraz Ruben T. , Du Jian , Yarema Kevin J. 
Published: June 2023

AbstractMetabolic glycoengineering (MGE) refers to a technique where non‐natural monosaccharide analogs are introduced into living biological systems. Once inside a cell, these compounds intercept a targeted biosynthetic glycosylation pathway and in turn are metabolically incorporated into cell‐surface‐displayed oligosaccharides, where they can modulate a host of biological activities or be exploited as tags for bioorthogonal and chemoselective ligation reactions. Over the past decade, azido‐modified monosaccharides have become the go‐to analogs for MGE; at the same time, analogs with novel chemical functionalities continue to be developed. Therefore, one emphasis of this article is to describe a general approach for analog selection and then provide protocols to ensure safe and efficacious analog usage by cells. Once cell‐surface glycans have been successfully remodeled by MGE methodology, the stage is set for probing changes to the myriad cellular responses modulated by these versatile molecules. This manuscript concludes by detailing how one of these detection methods—flow cytometry—can be successfully utilized to quantify MGE analog incorporation and set the stage for numerous follow‐up applications. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Incubation of cells with sugar analogsSupport Protocol: Routine growth and maintenance of Jurkat cellsBasic Protocol 2: Cell viability assaysBasic Protocol 3: Periodate‐resorcinol assay to measure analog uptake and incorporation into metabolic pathwaysBasic Protocol 4: Quantitation of cell‐surface glycoconjugates
Analysis of Neutrophil Responses to Biological Exposures
Authors: Anselmi Natalie K. , Bynum Kiana , Kay Jason G. , Visser Michelle B. 
Published: June 2023

AbstractNeutrophils are an important part of the innate immune system and among the first cells to respond to infections and inflammation. Responses include chemotaxis towards stimuli, extravasation from the vasculature, and antimicrobial actions such as phagocytosis, granule release, reactive oxygen species (ROS) production, and neutrophil extracellular trap (NET) formation (NETosis). Studying how neutrophils respond to a variety of stimuli, from biomaterial interactions to microbial insults, is therefore an essential undertaking to fully comprehend the immune response. While there are some immortalized cell lines available that recapitulate many neutrophil responses, ex vivo or in vivo studies are required to fully understand the complete range of neutrophil phenotypes. Here we describe two protocols for neutrophil isolation for further ex vivo study: recovery of neutrophils from human peripheral blood, and isolation of neutrophils from the oral cavity. We also discuss an in vivo model of general inflammation with the murine air pouch that can be used to assess numerous parameters of neutrophil and immune activation, including neutrophil recruitment and biological activity. In these protocols, the cells are isolated to allow for a high degree of experimental control. The protocols are relatively straightforward and can be successfully used by labs with no prior primary cell experience. © 2023 Wiley Periodicals LLC.Basic Protocol 1: Neutrophil isolation from human bloodBasic Protocol 2: Neutrophil isolation from the oral cavityBasic Protocol 3: Murine air pouch model of general inflammation
Target slinging of droplets with a flexible cantilever
Authors: Fang Wei , Wang Shun , Duan Hu , Tahir Shahid Ali , Zhang Kaixuan , Wang Lixia , Feng Xi‐Qiao , Song Meirong 
Published: June 2023

AbstractControl of the directional bounce of droplets impacting solid surfaces is crucial for many agricultural and industrial applications. However, for the universal impact process of raindrops on plant leaves, little is known about how the highly coupled and complicated fluid–structure interaction controls the postimpact motion of droplets and endows the leaves with tenacious vitality. Here, we report a leaf‐like superhydrophobic cantilever to flexibly bounce droplets with well‐defined directionality and controllability. Through theoretical modeling and three‐dimensional fluid–solid coupling simulations, we find that the flexible cantilever significantly relieves the impacting forces of raindrops to reduce droplet fragmentation and enhance water repellency. The results further uncover the scaling relations of the droplet bouncing direction with respect to Weber number and cantilever stiffness. By this technique, the seemed disorganized postimpact movements of droplets are programmable and predictable, achieving the goal of where to point and where to hit automatically. This work advances the understanding of natural droplet impact phenomena, opens a new avenue for delicately controlling liquid motion in space with soft materials, and inspires a plethora of applications like soft robots to transport materials and energies, monitor plant growth as well as predict pathogen transmission in plants.
Unauthorized ingredients in “nootropic” dietary supplements: A review of the history, pharmacology, prevalence, international regulations, and potential as doping agents
Authors: Jędrejko Karol , Catlin Oliver , Stewart Timothy , Anderson Ashley , Muszyńska Bożena , Catlin Don H. 
Published: June 2023

AbstractThe first nootropic prohibited in sport was fonturacetam (4‐phenylpiracetam, carphedon) in 1998. Presented here 25 years later is a broad‐scale consideration of the history, pharmacology, prevalence, regulations, and doping potential of nootropics viewed through a lens of 50 selected dietary supplements (DS) marketed as “cognitive enhancement,” “brain health,” “brain boosters,” or “nootropics,” with a focus on unauthorized ingredients. Nootropic DS have risen to prominence over the last decade often as multicomponent formulations of bioactive ingredients presenting compelling pharmacological questions and potential public health concerns. Many popular nootropics are unauthorized food or DS ingredients according to the European Commission including huperzine A, yohimbine, and dimethylaminoethanol; unapproved pharmaceuticals like phenibut or emoxypine (mexidol); previously registered drugs like meclofenoxate or reserpine; EU authorized pharmaceuticals like piracetam or vinpocetine; infamous doping agents like methylhexaneamine or dimethylbutylamine; and other investigational substances and peptides. Several are authorized DS ingredients in the United States resulting in significant global variability as to what qualifies as a legal nootropic. Prohibited stimulants or ß2‐agonists commonly used in “pre‐workout,” “weight loss,” or “thermogenic” DS such as octodrine, hordenine, or higenamine are often stacked with nootropic substances. While stimulants and ß2‐agonists are defined as doping agents by the World Anti‐Doping Agency (WADA), many nootropics are not, although some may qualify as non‐approved substances or related substances under catch‐all language in the WADA Prohibited List. Synergistic combinations, excessive dosing, or recently researched pharmacology may justify listing certain nootropics as doping agents or warrant additional attention in future regulations.
Characterizing the heterogeneity of eastern hemlock xylem water isotopic compositions: Implications for the design of plant water uptake studies
Authors: Li Kevin , Knighton James 
Published: June 2023

AbstractXylem water isotopic compositions (2H, 18O; δXYLEM) can be used to estimate plant water uptake depths; however, environmental heterogeneity in these measurements may prevent reaching robust conclusions. Bayesian mixing models used to estimate plant water uptake depths often assume that measurements of δXYLEM and candidate water uptake sources are normally and identically distributed. We tested if δXYLEM measured across 30 Eastern hemlock (Tsuga canadensis (L.) Carrière) trees met these assumptions. Bootstrap simulations suggested that the distributions of hemlock δXYLEM data were non‐normal in March, April, June, and July and that between 15 and 26 hemlock δXYLEM samples were required to reject the assumption of normality. In June, July, and August, δXYLEM was significantly predicted by a multivariate linear regression with tree sapwood depth or elevation, rejecting the assumption of independently distributed observations. A comparison of dry season hemlock water uptake depth estimates between a Bayesian mixing model and a process‐based ecohydrological model calibration showed differences, with the Bayesian model estimating a substantially greater proportion of shallow water uptake. These results highlight the need for standardized field sampling protocols for δXYLEM and analytical methods that will lead to more robust estimates of plant water uptake depths. These findings also suggest that water uptake functions conditioned on landscape and tree structural variables could substantially advance the representation of plants in ecohydrological models.