bluuebunny/crossref_metadata_2025_split huggingface dataset:
1593 FRAILTY AND OUTCOMES FOR OLDER PATIENTS TREATED IN A MAJOR TRAUMA CENTRE
Authors: Angus A , Flinn M , Wallace K , Gordon M W G , Capek E , Anand A 
Published: July 2023

Abstract

Introduction
Older people are the fastest growing group of hospitalised trauma patients, most commonly due to falls from standing height. The Scottish Trauma Audit Group (STAG) collect extensive national data, but this does not currently include frailty and longer-term dependency.

Method
We retrospectively reviewed consecutive cases in the STAG database for the Royal Infirmary of Edinburgh between September 2018 and February 2019. Casenote review was used to calculate baseline Charleston Comorbidity Index (CCI) and frailty status using the Clinical Frailty Scale (CFS). Outcomes of residence and mortality were collected to 1 year.

Results
We included 442 patients (mean age 62±20 years old, 43% female), of whom 218 (49%) were ≥65 years old (mean 78±8 years, 57% female). CFS could be ascertained in 209 (96%) patients ≥65 years, of whom 73 (35%) were frail (CFS ≥5). Frail patients were older (82±8 years vs. 77±8 years, p&lt;0.001) and had more comorbidities (mean CCI 5.4±1.8 vs. 4.4±1.8, p&lt;0.001) prior to trauma compared to non-frail patients &gt;65 years old. Median Injury Severity Scores (ISS) did not vary by age (9 [5-12] ≥65 years vs. 9 [8-16] &lt;65 years, p=0.07) or frailty status (9 [9-10] frail vs 9 [4-14] non-frail, p=0.59). Frail older patients were twice as likely to die within one year of trauma (32% vs 14% in non-frail, p&lt;0.001), and this was independent of age (adjusted odds ratio 2.4, 95% confidence intervals 1.2–4.9, p=0.02). In survivors to 1 year, 16% of frail older patients required increased care at home (vs. 8% of non-frail older patients, p&lt;0.001) and 14% were newly admitted to a care home (vs. 4% of non-frail, p&lt;0.001).

Conclusion
A third of older patients with trauma are frail and this is an important predictor of patient outcomes beyond death. Frailty provides more prognostic information than age in this setting.
eBiBa: A Post-Quantum Hash-Based Signature With Small Signature Size in the Continuous Communication of Large-Scale Data
Authors: Li Lingyun , Lu Xianhui , Wang Kunpeng 
Published: July 2023

Abstract
We present eBiBa (enhanced BiBa), a hash-based signature scheme with the smallest possible signature size, while ensuring high feasibility and security in a specific application model. Our scheme is tailored to address the communication requirement of a large-scale public data stream continuously disseminated between two participants while ensuring data source and data integrity authentication. To achieve these goals, firstly, we optimized the classical hash tree mode into a hybrid mode to efficiently perform public key authentication and eliminate the need for an authenticated channel to transmit large amounts of data, unlike the initial BiBa-based broadcast authentication protocol. Secondly, we employed a specific tweakable hash chain function to digest a batch of messages, reducing the required conditions for post-quantum existential unforgeability under adaptive chosen message attack (EUCMA) of eBiBa to a second-pre-image-resistance-like property instead of collision resistance. This results in reduced pre-computation in both key and signature generations. Thirdly, we utilized a forward-secure pseudorandom function to achieve forward-secure of the proposed scheme. Finally, we minimize the signature size through a series of procedures. Firstly, we select BiBa few-time signature as the underlying signature scheme since it is currently the few-time hash-based signature with the smallest signature size that we are aware of; in addition, the hybrid approach we employed can also significantly reduce the signature size compared to using a hash tree solely; for the hash tree structure, we design a specific authentication path in combination with the related communication model to further minimize the signature size; finally, we optimize the authentication approach to achieve the minimum signature size in a single transmission. Our construction minimizes the signature size in the aforementioned model, achieving a compression rate of 0.017 to 0.828 based on distinct values of parameters, as compared to XMSS-256. We also demonstrated that eBiBa can achieve post-quantum forward-secure and EUCMA security.
Farmers’ acceptance of the income stabilisation tool: a discrete choice experiment application
Authors: Čop Tajana , Cerroni Simone , Njavro Mario 
Published: July 2023

Abstract
The income stabilisation tool (IST) is the latest tool proposed by the European Union (EU) to manage agricultural risks. It aims at stabilising farm income by compensating income losses. Using a discrete choice experiment, this paper investigates grapevine farmers’ acceptance of the IST in Croatia and tests whether behavioural factors such as risk preferences, probability weighting and subjective probabilities related to future farm income explain acceptance of this new tool. Results suggest that there is demand for the IST. Pessimistic farmers are more likely to participate in the IST than others, suggesting that subjective probabilities influence farmers’ decisions about agricultural risk management.
Left ventricular assist device explantation using a new double-patch technique
Authors: Bhadra Oliver Daniel , Pausch Jonas , Aubin Hug , Akhyari Payam , Lichtenberg Artur , Barten Markus Johannes , Alassar Yousuf , Reichenspurner Hermann , Bernhardt Alexander Markus 
Published: July 2023

Abstract

OBJECTIVES
There are several surgical approaches for explanting a left ventricular assist device (LVAD) after recovery of cardiac function. Thus, remaining ventricular assist device components may bear significant risks of infection or thrombosis. We hereby report our technique and two-center experience with explantation of LVADs using a new double-patch technique.

METHODS
From March 2019 to April 2021, five patients underwent LVAD explantation after myocardial recovery (HVAD, n = 2; HeartMate 3, n = 3). The mean patient age was 50.3 years (100% male); the mean time on the LVAD was 23.1 ± 20.8 months. The aetiology of the primary heart failure was dilated cardiomyopathy (n = 4) and myocarditis (n = 1).
LVAD explantation was performed using a median sternotomy and cardiopulmonary bypass. The LVAD was stopped, and the outflow graft was clamped. The outflow graft was ligated and sutured close to the aortic anastomosis. The driveline was clipped and removed. Under induced fibrillation, the attachment of the LVAD was released from the apical cuff and the LVAD was removed. A round pericardial patch was fixed from the inner of the ventricle. This step sealed the apex of the heart. An additional Gore-Tex patch was continuously sutured epicardially over the suture ring.

RESULTS
The 5 cases showed technically uncomplicated explantation of the LVADs. During the follow-up of a mean of 16.4 ± 16.9 months, we observed 100% survival. There were no bleeding complications or thromboembolic events during the follow-up period.

CONCLUSIONS
LVAD explantation with the double-patch technique is feasible and safe. This technique allows discontinuation of anticoagulation. The 30-day survival was 100%. Further studies are needed to provide better evidence for LVAD explantation and long-term follow-up.
Cyber and AI security challenges for LNG maritime transport and terminals—responses in law and standards
Authors: Jao Juei-Cheng , Chuah Jason C T 
Published: July 2023

Abstract
This article considers how key state players in the maritime transport and storage of liquefied natural gas (LNG) face up to the cyber security threats which have sadly become ubiquitous in recent times. The cyber threat for the gas sector, with increasing investment in LNG and current geopolitics, makes the study especially acute.
Targeted RNA condensation in living cells via genetically encodable triplet repeat tags
Authors: Xue Zhaolin , Ren Kewei , Wu Rigumula , Sun Zhining , Zheng Ru , Tian Qian , Ali Ahsan Ausaf , Mi Lan , You Mingxu 
Published: July 2023

Abstract
Living systems contain various membraneless organelles that segregate proteins and RNAs via liquid–liquid phase separation. Inspired by nature, many protein-based synthetic compartments have been engineered in vitro and in living cells. Here, we introduce a genetically encoded CAG-repeat RNA tag to reprogram cellular condensate formation and recruit various non-phase-transition RNAs for cellular modulation. With the help of fluorogenic RNA aptamers, we have systematically studied the formation dynamics, spatial distributions, sizes and densities of these cellular RNA condensates. The cis- and trans-regulation functions of these CAG-repeat tags in cellular RNA localization, life time, RNA–protein interactions and gene expression have also been investigated. Considering the importance of RNA condensation in health and disease, we expect that these genetically encodable modular and self-assembled tags can be widely used for chemical biology and synthetic biology studies.
Antibody responses following the surge of SARS-CoV-2 Omicron infection among patients with systemic autoimmune rheumatic diseases
Authors: Xiang Nan , Li Yu-Jing , Liu Meng-Yao , Wu Qi-Qin , Zhang Ya-Xin , Jin Hui-Zhi , Wang Qian , Li Yu-Wei , Tong Da-Li , Xue Tian , Jin Teng-Chuan , Bao Wei , Chen Zhu 
Published: July 2023

Abstract

Objectives
The surge of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant Omicron infections has affected most Chinese residents at the end of 2022, including a number of patients with systemic autoimmune rheumatic diseases (SARDs).

Methods
To investigate the antibody level of the Omicron variant in SARD patients after SARS-CoV-2 Omicron infection, we tested BA.5.2 and BF.7 Omicron variant IgG antibody levels using ELISA on blood samples collected from 102 SARD patients and 19 healthy controls (HCs). The type of SARD, demographics, concurrent treatment, doses of SARS-CoV-2 vaccines and outcomes were also recorded.

Results
A total of 102 SARD patients (mean age: 40.3 years; 89.2% female), including 60 SLE, 32 RA and 10 other SARDs, were identified. Of these, 87 (85.3%) were infected with SARS-CoV-2. We found that the BA.5.2 and BF.7 antibody levels of infected SARD patients were lower than those of HCs (P &lt; 0.05). Sixty-five (63.7%) patients had at least one dose of a SARS-CoV-2 vaccine. SARD patients with at least two doses of SARS-CoV-2 vaccine had a higher level of BA.5.2 and BF.7 antibodies than the unvaccinated group (P &lt; 0.05). There was no evidence for a significant inhibitory effect of glucocorticoids (GCs) on the BA.5.2 and BF.7 Omicron variant antibody levels in SARD patients. SLE patients using biologic DMARDs had a lower BA.5.2 Omicron variant antibody level than patients using GCs and/or HCQ.

Conclusion
These data suggest that patients with SARDs had a lower antibody response than HCs after Omicron infection.
Fungicide Use Patterns in Select United States Wine Grape Production Regions
Authors: Oliver Charlotte , Cooper Monica , Ivey Melanie Lewis , Brannen Phillip , Miles Timothy , Lowder Sarah , Mahaffee Walter , Moyer Michelle M. 
Published: July 2023

Wine grape production (Vitis sp.) in the United States requires fungicide inputs for disease control. Currently, there is limited data available on vineyard fungicide use patterns. This information is important in developing tailored recommendations for disease management and fungicide stewardship. In this paper, we summarize the wine grape vineyard fungicide use patterns from four major regions: Napa and Sonoma valleys (California), Willamette Valley (Oregon), Columbia Valley (Washington), and several smaller regions east of the Mississippi River in years 2009 to 2020. We learned that the average in-season total fungicide applications ranged regionally from 5.6 to 8. The most commonly applied Fungicide Resistance Action Committee (FRAC) codes in spray programs were FRAC 3, 13, and M02 across all regions, with some variation to the top four groups in each region. Most applications were made on 14-day intervals; however, shorter intervals (7-day) were favored early season, and longer intervals (21-day) were favored late season. Tank-mixing multiple active ingredients was common east of the Mississippi River during all stages of grape development; this action was typically favored during the bloom period in other regions. In a subset of records that participated in FRAC 11 fungicide resistance testing, the average number of FRAC 11 applications after testing was reduced to either no applications or one application in Napa and Sonoma valleys. This survey provides regionally specific data related to fungicide stewardship practices that could be a focus for future stewardship messaging and fungicide resistance selection training, including total product use (selection events), spray intervals (selection pressure), and tank mixing (selection management). [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
‘Candidatus Liberibacter asiaticus’ Expands and Scavenges the Nutritional Choline Pool in Its Host Grapefruit (Citrus × paradisi) Leaves
Authors: Jain Mukesh , Cai Lulu , Gabriel Dean W. 
Published: July 2023

Phosphatidylcholine (PtdCho) is an unusual membrane phospholipid present in some endosymbiotic and intracellular pathogenic prokaryotes. ‘ Candidatus Liberibacter asiaticus’ (CLas) is a phloem-limited, uncultured, fastidious α-Proteobacterium associated with the devastating citrus “greening” disease (huanglongbing). Phylogenetically related but nonpathogenic Liberibacter crescens (Lcr) was used as a culturable surrogate to examine PtdCho biosynthesis in pathogenic CLas. Genes encoding key enzymes for two alternative PtdCho biosynthetic routes are present in the Lcr genome: the one-step cytidine diphosphate (CDP)-choline ( pcs-encoding phosphatidylcholine synthase) and the three-step methyl-transferase pathway ( pmt-encoding phospholipid N-methyltransferase). However, only the CDP-choline pathway genes for incorporating exogenous Cho were identified in the CLas genome. Exogenous Cho enhanced growth and alleviated osmotic stress in wild-type Lcr and in the pmt insertion mutant strains when cultured in a sugar-rich medium. Quantitative RT-PCR analyses confirmed active uptake and condensation of nutritional Cho into PtdCho by CLas in both its plant host and psyllid vector. CLas-infected grapefruit leaves showed transcriptional activation of Cho biosynthesis genes and 2.8-fold higher levels of Cho. In plant cells, the compatible osmolyte glycine-betaine (GlyBet) is also derived from Cho. Expression of GlyBet biosynthesis genes and the GlyBet content were similar in both CLas-infected and healthy leaf tissue. The data presented here suggest that CLas likely exploits the Cho biosynthetic pathway in citrus hosts to expand the nutritional Cho pool. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Patient Experience and Clinical Outcomes after Same-day Outpatient Mastectomy and Immediate Breast Reconstruction Protocol during the Global Pandemic
Authors: Mohan Anita T. , MacArthur Taleen A. , Murphy Brenna , Song Allisa J. , Saifuddin Hiba , Degnim Amy , Harmsen William S. , Martinez-Jorge Jorys , Jakub James W. , Vijayasekaran Aparna 
Published: July 2023

Background:The coronavirus disease 2019 (COVID-19) pandemic provoked rapid changes in clinical practice to accommodate mandated restrictions within healthcare delivery. This study reviewed patient-reported experiences and clinical outcomes after implementation of a same-day discharge protocol after mastectomy with immediate alloplastic breast reconstruction compared with our historical overnight stay protocol.Methods:This is a retrospective single-institution study of consecutive patients who underwent mastectomy and immediate alloplastic reconstruction between July 2019 and November 2020. A postoperative survey was completed by patients to evaluate satisfaction with perioperative communications, recovery, and their overall experience.Results:A total of 302 patients (100% women) underwent mastectomy and immediate alloplastic reconstruction (174 pre-COVID-19, 128 during COVID-19). During COVID-19, 71% of patients were scheduled for a same-day discharge, among which 89% were successfully discharged the same day. Compared with pre-COVID-19, there were no differences in type of surgery, operative times, pain scores, 30-day readmission, or unplanned visits (allP> 0.05) during the COVID-19 pandemic. Compared with pre-COVID-19, patients during the pandemic reported comparable satisfaction with their care experience and postoperative recovery (56% survey response rate). Patient satisfaction was also similar between those discharged the same day (n = 81) versus the next day (n = 47) during COVID-19.Conclusions:Same-day discharge is feasible, safe, and can provide similar patient-reported satisfaction and outcomes compared with traditional overnight stay. These data highlight the ability to deliver adaptable, high-quality breast cancer care, within the constraints of a global pandemic.
Increasing depth of focus with allogeneic presbyopic inlays: 3-year results
Authors: Keskin Perk Fatma Feyza Nur , Taneri Suphi , Tanriverdi Cafer , Haciagaoglu Sezer , Karaca Zeki Yigit , Kilic Aylin 
Published: July 2023

Purpose:
To demonstrate the safety and efficacy of allogenic corneal inlays designed to increase the depth of focus (DoF) in treated eyes.

Settings:
Medipol University Hospital, Istanbul, Turkey.

Design:
Prospective case series.

Methods:
This study includes 50 eyes of 25 patients with a follow-up of 3 years. Emmetropic patients with presbyopia had implantation of allogenic corneal inlays in the nondominant eye. The uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and uncorrected near visual acuity (UNVA) were evaluated in all eyes. A subjective visual acuity test system (Multifocal Lens Analyzer 3.0 application) was used to analyze the DoF by measuring the defocus curves.

Results:
No significant difference between the treated and fellow eyes in UDVA and CDVA was found, whereas UNVA was significantly better in the treated eyes (P = .20, P = .07, P < .01, respectively). Comparing to the preoperative CDVA, there was a 1-line decrease in CDVA in 6 (%24) patients. The mean defocus curves reveal a DoF of 1.1 diopters (D) for the untreated eye at the logMAR = 0.2 threshold. By contrast, the mean DoF of the treated eye and binocularly was 2.8 D. The areas under the curve were significantly better in the near, intermediate, and total distances in the treated eyes, whereas it was better for the far distances in the untreated eyes. All values were significant (P = .023 total, P < .01 others).

Conclusions:
Allogenic presbyopic inlay implantation may be safe and provided a clinically and statistically significant increase in the DoF leading to good far, intermediate, and near-visual acuity in emmetropic presbyopic patients.
False-Positive 68Ga-DOTATATE Uptake in a Uterine Subserosal Fibroid Mimicking Mesenteric Neuroendocrine Tumor
Authors: Khalaj Kamand , Rowe Julie H. , Thupili Chakradhar R. , Tammisetti Varaha S. 
Published: July 2023

Abstract

68Ga-DOTATATE PET/CT is a highly sensitive and specific imaging modality in detecting neuroendocrine tumors. False-positive DOTATATE uptake poses diagnostic challenges. False-positive uptake in a uterine fibroid is the third most common location. We report the case of a 45-year-old woman with clinical concern for possible neuroendocrine tumor showing moderate focal DOTATATE uptake, which was initially thought of to be localized to mesentery on PET/CT images but was subsequently localized to a subserosal uterine fibroid following MRI. Patient underwent hysterectomy, further confirming that the uterine myometrial uptake is within the subserosal fibroid.
Lung Nodule as Culprit Lesion Causing Recurrent Tumor-Induced Osteomalacia Revealed by 68Ga-DOTATATE PET/CT
Authors: Zhang Yuwei , Wang Peipei , Jing Hongli 
Published: July 2023

Abstract
Neoplasms that cause tumor-induced osteomalacia are very rarely located in the lung. A 27-year-old man underwent a surgery in the right femoral head to remove the tumor that induced osteomalacia 8 years ago with complete symptomatic relief. However, his bone pain occurred again recently, which lead to suspicion of a recurrent tumor-induced osteomalacia. 68Ga-DOTATATE PET/CT images showed a pulmonary nodule with mildly increased uptake along with increased activity in the left foot. The pulmonary nodule was subsequently resected and was pathologically confirmed as a phosphaturic mesenchymal tumor. The symptoms were completely relieved postsurgery.
What We Know About Intracranial Hypertension in Children With Syndromic Craniosynostosis
Authors: Doerga Priya N. , Goederen Robbin de , van Veelen Marie-Lise C. , Joosten Koen F.M. , Tasker Robert C. , Mathijssen Irene M.J. 
Published: July 2023

Objective:
A scoping review of literature about mechanisms leading to intracranial hypertension (ICH) in syndromic craniosynostosis (sCS) patients, followed by a narrative synopsis of whether cognitive and behavioral outcome in sCS is more related to genetic origins, rather than the result of ICH.

Methods:
The scoping review comprised of a search of keywords in EMBASE, MEDLINE, Web of science, Cochrane Central Register of Trials, and Google scholar databases. Abstracts were read and clinical articles were selected for full-text review and data were extracted using a structured template. A priori, the authors planned to analyze mechanistic questions about ICH in sCS by focusing on 2 key aspects, including (1) the criteria for determining ICH and (2) the role of component factors in the Monro-Kellie hypothesis/doctrine leading to ICH, that is, cerebral blood volume, cerebrospinal fluid (CSF), and the intracranial volume.

Results:
Of 1893 search results, 90 full-text articles met criteria for further analysis. (1) Invasive intracranial pressure measurements are the gold standard for determining ICH. Of noninvasive alternatives to determine ICH, ophthalmologic ones like fundoscopy and retinal thickness scans are the most researched. (2) The narrative review shows how the findings relate to ICH using the Monro-Kellie doctrine.

Conclusions:
Development of ICH is influenced by different aspects of sCS: deflection of skull growth, obstructive sleep apnea, venous hypertension, obstruction of CSF flow, and possibly reduced CSF absorption. Problems in cognition and behavior are more likely because of genetic origin. Cortical thinning and problems in visual function are likely the result of ICH.