bluuebunny/crossref_metadata_2025_split huggingface dataset:
JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation
Authors: Lee Gilyoung , Ahn Huijeong , Yun Jang-Hyuk , Park Jeongho , Lee Eunsong , Oh Seikwan , Lee Geun-Shik 
Published: December 2022

AbstractDysregulation of inflammasome activation induces chronic and excess inflammation resulting in several disorders, such as metabolic disorders and cancers. Thus, screening for its regulator derived from natural materials has been conducted progressively. JC2-11 (JC) was designed to enhance the antioxidant activity based on a chalcone, which is abundant in edible plants and a precursor of flavonoids. This study examined the effects of JC on inflammasome activation in human and murine macrophages. JC inhibited the secretion of interleukin (IL)-1β and lactate dehydrogenases, and the cleavage of caspase-1 and gasdermin D in response to the tested activators (i.e., NLRP3, NLRC4, AIM2, and non-canonical inflammasome triggers). In addition, JC attenuated IL-1β secretion from lipopolysaccharide (LPS)-injected mice, an inflammasome-mediating disease model. Mechanistically, JC blocked the expression of the inflammasome components during the priming step of the inflammasome, and interrupted the production of mitochondrial reactive oxygen species. In addition, JC inhibited the activity of caspase-1. In conclusion, JC may be a candidate pan-inflammasome inhibitor.
The technique and its role of dacryoendoscopy in the management of the false passage of the lacrimal drainage system
Authors: Kim Myungjin , Lew Helen 
Published: December 2022

AbstractThis is a retrospective study of patients with primary acquired nasolacrimal duct obstruction (PANDO) who underwent dacryoendoscopy (FT-203F; Fibertech Co., Tokyo, Japan) and sheath-guided silicone intubation for 830 cases with PANDO from March 2016 to December 2020. 19 cases (2.3%) were observed as false passage in the lacrimal drainage system (LDS). Dacryoendoscopic findings revealed that the following factors were associated with LDS obstruction (% cases): structural change of 63.2% (stenosis, 42.1%; fibrotic membrane, 21.1%), and secretory change of 36.8% (mucus, 15.8%; stone, 10.5%; and granulation, 10.5%). The obstruction sites were distributed through LDS. The false passages detected in LDS were managed as follow: usage of fluid irrigation pressure to check the true passage following the previously intubated silicone tube as a reference, and confirmation the end of passage through the inferior meatus with nasal endoscopy. The overall success rate was 73.7% using this management technique. Dacryoendoscopy enables real-time observation of the lumen of the LDS, thus facilitating management of pathological lesions including false passages. With this technique, we are better able to make customized treatment of patients with false passages, with a safer and more effective results leading to the success of dacryoendoscopy guided silicone tube intubation in PANDO patients.
Improved equation to describe the induction motor currents during nearby three‐phase short‐circuits
Authors: Sorrentino Elmer , Vera Andres 
Published: December 2022

AbstractThis article shows an improved equation to describe the induction motor currents during a three‐phase short‐circuit near to motor terminals. The proposed equation considers three details which are not in the equation shown in the IEEE Std. 551: (a) the equivalent frequency of these currents is not strictly equal to the grid frequency; (b) the magnitude of the DC component is not strictly equal to the magnitude of the AC component; (c) an angle is included to consider the instant of fault occurrence. The proposed equation was verified by experimental results, which were also verified by simulations. It is shown that the equivalent frequency of analysed currents is not exactly the grid frequency due to the sudden change of the machine speed (caused by the high braking torque originated by high transient currents during the short‐circuit). This effect is larger in smaller motors. The AC and DC components of the analysed currents have their own time constants, which are usually estimated from motor equivalent circuit. The application of the improved equation was useful to demonstrate that such a procedure does not lead to accurate results in case of the DC time constants of small motors. Finally, an example illustrates a case that cannot be well described by the equation from the IEEE Std. 551, whereas the result from the proposed equation is very similar to the measured current.
Defining a new index to compare the resilience of different structures of an electrical energy network
Authors: Dehghani Arash , Sedighizadeh Mostafa , Haghjoo Farhad 
Published: December 2022

AbstractThe issue of resilience in electrical distribution systems has been proposed increasingly with the frequent occurrence of natural disasters in recent years and the imposition of high costs due to widespread power outages. To date, various resilience indices have been proposed, some of which have been improved upon over time by extensive research, leading to more comprehensive indices. However, a standard index has not yet been approved and presented in this regard by international committees, despite the efforts made. The issue of resilience in electrical networks was examined by curve analysis index in more detail compared to other proposed indices, although it is not yet complete and should be investigated from various aspects and its shortcomings be eliminated. The present study aims to evaluate some fundamental obstacles in the “curve analysis” index and correct it in a new index called “Combining Investment and Reform” (CIR) index. Two issues of “costs in terms of investment and repairs imposed by the event” and “need to separate critical and non‐critical loads” are considered simultaneously in the proposed index. Finally, the capabilities of the proposed index are evaluated and compared in a sample electrical network in the face of events with different intensities.
SRI3D: Two‐stream inflated 3D ConvNet based on sparse regularization for action recognition
Authors: Yang Zhaoqilin , An Gaoyun , Zhang Ruichen , Zheng Zhenxing , Ruan Qiuqi 
Published: December 2022

AbstractAlthough most state‐of‐the‐art action recognition models have adopted a two‐stream 3D convolutional structure as a backbone network, few works have studied the impact of loss functions on action recognition models. In addition, sparsity is used as a key prior knowledge in many fields. However, as far as is known, no one has studied the influence of the sparsity of network output on the output of deep learning‐based action recognition models. Therefore, this paper proposes a novel two‐stream inflated 3D ConvNet based on the sparse regularization (SRI3D) model for action recognition. In order to allow the network to learn the sparsity of output, the ℓ1 norm is embedded in the loss function in regularization form in a plug‐and‐play manner. It can make the classification result after the fusion of the two‐stream network only be the category with the highest confidence in one of the streams and not the other cases. The proposed loss function based on sparse regularization makes the output vector of the neural network as sparse as possible so that the classification results will not be ambiguous. Experimental results show that compared with other state‐of‐the‐art models, this SRI3D has a competitive advantage on Kinetics‐400, Something‐Something V2, UCF‐101 and HMDB‐51.
A stochastic multi‐objective model for energy efficiency and renewable resource planning in energy communities: A sustainably cost‐effective trade‐off
Authors: Afzali Peyman , Rashidinejad Masoud , Abdollahi Amir , Salehizadeh Mohammad Reza , Farahmand Hossein 
Published: December 2022

AbstractThe integration of energy efficiency programs and renewable resources in energy communities (EC) incorporating smart microgrids might be the future development of sustainable cities. Cooperation among EC with high penetration of renewable energy resources will support energy procurement. Mutual energy efficiency programs in EC associated with deploying renewable resources can guarantee sustainable development significantly. This paper proposes a new sustainability index (SI) influenced by the loss of load reduction while increasing the penetration of renewable energies. A multi‐objective optimization method is used to determine the optimal size and location of renewable resources incorporating energy efficiency programs. The objective functions, that is, the total cost and SI, are based upon social, economic, environmental, and technical (SEET) considerations. Since the outputs of renewable energies are uncertain, it may increase the loss of load probability. Therefore, this paper introduces a model that can handle the uncertainties of renewable energies. A new method so‐called adaptive multi‐objective crow search algorithm (AMCSA) is developed for the trade‐off between cost and sustainability in the optimization problem. The proposed methodology cannot only minimize the total cost in EC but also will maximize the SI. Simulation studies and results analysis indicates the effectiveness of the proposed methodology for the development of sustainability and renewable energies in the smart grid.
Uso de placa malla en el manejo de fracturas conminutas de patela: Reporte de caso
Authors: Franulic Nicolás , Laso José Ignacio , Rojas Carlos , Olivieri Rodrigo , Gaggero Nicolás 
Published: December 2022

Resumen
Objetivos Describir la técnica quirúrgica para el uso de placa malla en un caso de fractura conminuta de patela y sus resultados en el seguimiento a mediano plazo.
Materiales y Métodos Presentamos un caso de fractura conminuta de patela manejada con el uso de una placa malla y un tornillo canulado asociado, evitando de esta forma la patelectomía parcial y sus posibles complicaciones.
Resultados El paciente presentó una evolución satisfactoria, con rango de movimiento de rodilla completo y en condiciones de alta laboral a los cuatro meses desde la cirugía, sin complicaciones ni reintervenciones.
Discusión El uso de placas malla permite el manejo de fracturas conminutas de patela preservando stock óseo y restaurando la indemnidad del aparato extensor, con una osteosíntesis estable y poco prominente. Casos en que antiguamente la única alternativa era la patelectomía parcial y reinserción del tendón patelar ahora tienen etas placas como opción de manejo.
Conclusión El uso de placas malla en fracturas conminutas de patela es una alternativa atractiva por la estabilidad que brindan, la capacidad de preservar stock óseo, y la baja tasa de reintervenciones.
Nivel de evidencia V.
The Relationship between Unilateral Palatal Maxillary Canine Impaction and the Morphology of the Maxilla: A CBCT Study in Eastern Province of Saudi Arabia
Authors: Shahin Suliman Y. , Tabassum Afsheen , Fairozekhan Arishiya Thapasum , Tuwaylib Ahmed Al , Al-Sheyoukh Saeed , Alzaher Shuaib , Siddiqui Intisar Ahmad , Alhareky Muhanad 
Published: December 2022

Abstract
Objective This study aimed to examine the correlation between the morphology of the maxilla and unilateral palatally impacted maxillary canine (PIMC) among the Saudi population in the Eastern Province of Saudi Arabia.
Materials and Methods In this retrospective study, 36 patients' records [(17 PIMC, 8 male, 9 female, mean age 16.75 ± 2.12 years) (19 control; 9 male,10 female, mean age: 17.16 ± 2.12 years)] were included from a teaching dental hospital. On cone-beam computed tomographic images, measurements of maxillary arch length (MAL), palatal vault depth (PVD), intermolar width, sum of widths of 4 maxillary incisors, available arch space (AAS), palatal maxillary width (PMW) in the molar and premolar regions, nasal cavity width (NCW), maxillary arch shape (MAS) (arch length/intermolar width x 100), and palatal vault shape (PVS) (the PVD/intermolar width x100) were performed. Data were analyzed by SPSS-20.0. p-value less than or equal to 0.05 reflected statistical significance.
Results This study's findings depicted that AAS (p = 0.012), PVD (p = 0.028), and PMW in the molar and premolar regions at the level of the alveolar crest (p = 0.002 and p = 0.034) and mid-root (p = 0.004 and p = 0.022) were significantly higher in the control compared to the PIMC group. PVS showed a significant difference between the PIMC and control groups (p = 0.037). However, regarding MAS, no significant difference was observed (p = 0.707).
Conclusion MAS was narrower in PIMC compared to the control group. The control group had a deeper palatal vault and greater AAS compared to the PIMC group. However, no significant difference was observed between groups regarding tooth size or NCW.
Dysplasia at the Anal Transition Zone after IPAA
Authors: Church James 
Published: December 2022

AbstractIleal pouch-anal anastomosis is a popular way of reconstruction the gastrointestinal tract after total proctocolectomy for ulcerative colitis. The pouch-anal anastomosis is usually stapled, which requires the preservation of a small amount of upper anal canal and lower rectum. This includes the anal transition zone (ATZ), a surprisingly small and irregular ring of tissue at and just above the dentate line. The ATZ and rectal cuff is prone to inflammation and neoplasia, particularly in patients who had a colon cancer or dysplasia at the time their large bowel was removed. This high-risk group needs ATZ/rectal cuff surveillance before and after the surgery. Those without colorectal dysplasia preoperatively are at low risk of developing ATZ/rectal cuff dysplasia postoperatively and follow-up can be more relaxed. Treatment of ATZ dysplasia is difficult and may mean mucosectomy, pouch advancement, pouch removal, or a redo pelvic pouch.
Use of lacosamide in children: experience of a tertiary medical care center in Brazil
Authors: Romão Tayla Taynan , Angelim Abraão Iuri Medeiros , Prado Henrique Jannuzzelli Pires do , Goes Fernanda Veiga de , Pires Maria Elisa Paiva , Fontana Rosiane da Silva , Pires Lais de Carvalho , Fernandes Alexandre Ribeiro , D'Andrea-Meira Isabella 
Published: December 2022

Abstract
Background Lacosamide (LCM) is a third-generation anti-seizure drug approved in Europe and the United States, either as a monotherapy or adjunctive therapy, to treat partial-onset seizures in adults, adolescents, and children. In Brazil, LCM is licensed for treatment only in patients older than 16 years of age.
Objective To evaluate a cohort of children presenting with refractory epilepsy who received LCM as an add-on therapy and observe the response and tolerability to the LCM treatment.
Methods A retrospective cohort study conducted in a tertiary health care facility, which included 26 children, aged up to 16 years, who presented with refractory epilepsy and received LCM as an add-on treatment. The follow-up visits were scheduled every 3 months until 9 months of treatment with LCM.
Results After 3 months of LCM administration, in 73.1% of the children, there was a reduction of > 50% in the frequency of seizures, and this clinical improvement was maintained in most patients (73.9%) for the following 9 months. Mild (such as, somnolence and behavioral changes) or severe (seizure worsening) adverse effects were observed in two and three children respectively. Among responders to LCM, there was a higher prevalence of males, fewer concomitant anti-seizure drugs, and lower percentage of patients using sodium channel blockers.
Conclusions Lacosamide should be considered as an early treatment option in pediatric patients with refractory epilepsy, mainly focal seizures.
Interaction between apolipoprotein E genotypes, excessive daytime sleepiness, and cognitive function in obstructive sleep apnea patients
Authors: Balthazar Fernanda Maurer , Moraes Walter André dos Santos , Hunter James Richard , Prado Gilmar Fernandes do , Carvalho Luciane Bizari Coin de 
Published: December 2022

Abstract
Background Some studies show an association between the apolipoprotein E ε4 allele (ApoEε4) and obstructive sleep apnea syndrome (OSAS), and other studies, an association between ApoEε4 and excessive daytime sleepiness (EDS), but there are no data in the literature on the interaction between EDS, cognitive function, and ApoEε4 in patients with OSA.
Objective To examine the cognitive function of adults with and without EDS and with and without ApoEε4.
Methods A total of 21 male and female patients aged between 33 and 79 years, underwent a clinical interview, ApoE genotyping, neuropsychological evaluation, polysomnography, and the application of the Epworth Sleepiness Scale.
Results Excessive daytime sleepiness was associated with lower intelligence quotient (IQ; total performance) and worse immediate visual memory, regardless of the ApoE genotype. Patients carrying the ApoEε3/ε4 genotype had a worse performance in divided attention, constructional praxis, perceptual organization, and cognitive flexibility. A combination of the ε4 allele and EDS potentiates the negative effect on cognition, except for immediate visual memory. In this case, patients had a worse performance in terms of processing speed, selective attention, and visuomotor coordination.
Conclusions Excessive daytime sleepiness and the ApoEε3/ε4 genotype are associated with worse cognitive performance in OSA patients. The combination of EDS and ε4 allele potentiates cognitive impairment.
Depressive symptoms and axial motor disorders in individuals with Parkinson's disease: a cross-sectional study
Authors: Artigas Nathalie Ribeiro , Dutra Ana Carolina Leonardi , Soares Nayron Medeiros , Pereira Gabriela Magalhães , Leotti Vanessa Bielefeldt , Krimberg Julia Schneider , Pagnussat Aline de Souza , Rieder Carlos Roberto de Mello 
Published: December 2022

Abstract
Background Depression is an important nonmotor symptom of Parkinson's disease (PD) and has been associated with the motor symptoms in these individuals.
Objectives To determine whether there are relationships between depressive symptoms and abnormalities in axial postural alignment and axial motor deficits, especially postural instability, and trunk rigidity in PD.
Methods In this cross-sectional study, 65 individuals were evaluated using the Beck Depression Inventory-II (BDI-II) for the analysis of depressive symptoms and underwent a postural assessment of head, trunk, and hip sagittal alignment through computerized photogrammetry. The MDS-UPDRS was used to assess clinical aspects of PD, the Trunk Mobility Scale was used to assess axial rigidity, and the MiniBESTest to assess balance. To determine the relationship between depressive symptoms and postural alignment, multiple linear regression analysis was performed.
Results The participants with depressive symptoms had more severe motor deficits as well as greater trunk rigidity and worse postural instability (p < 0.05). When the postural angles were compared between men and women using Student's t-test, it was found that men had greater flexion angles of the head (p = 0.003) and trunk (p = 0.017). Using multiple linear regression analysis corrected for the age and sex of the participants, we verified that the anterior trunk inclination was significantly larger in the PD population with depressive symptoms (R2 = 0.453, β = 0.116, and p = 0.045).
Conclusion PD individuals with depressive symptoms have more severe flexed trunk posture, mainly in older men. Additionally, more severe depressive symptoms are associated with worsening postural instability, trunk rigidity and motor deficits in this population.
Anatomical description of the brain wax models of Museu da Pharmacia de Ouro Preto
Authors: Sousa Luiz Eduardo , Borges Ingrid da Silva , Seidel Helen , Pereira Isadora Lopes , Farias Juliana de Paula 
Published: December 2022

Abstract
Background In 1839, the Escola de Farmácia de Ouro Preto pioneered the teaching of pharmaceutical sciences in Brazil. At the end of the 19th century, the Escola de Farmácia possessed a French collection of anatomical models, some made of wax and paper-mâché. The models were a critical part of teaching anatomy, particularly in an era of paradigm changes about how the human brain works.
Objective The present study aimed to anatomically describe the brain models through a comparative analysis with the current anatomical description.
Methods Comparative analysis of the brain models with modern anatomical descriptions.
Results In the individual analysis of the wax models, we verified excellent anatomical accuracy of the cortical and subcortical regions. Our results identified internal structures, like the basal ganglia and white matter. Compared with modern anatomical books and websites, the wax brain models have high scientific quality.
Conclusion The models of the present study gave students hands-on experience of human anatomy in the 19th century. Nowadays, the models are part of the memory of Universidade Federal de Ouro Preto and Museu da Pharmacia de Ouro Preto . The collection of wax models shows the appreciation of neuroanatomy teaching at the turn of the century concomitant with advances in neurology and anatomy around the world.
Experiencia con el uso de toxina botulínica en niños con vejiga hiperactiva neurogénica: Una serie de casos
Authors: Bolaños Andrea , Larios Carlos , Ramos Hernandez Anamaria , López de Mesa Rodríguez Byron Eduardo , Peralta Sara Rocío , Noreña Luisa 
Published: December 2022

Resumen
Objetivo Describir la experiencia con la administración de inyección de toxina botulínica en niños con vejiga hiperactiva neurogénica refractaria a manejo de primera línea.
Materiales y Métodos Estudio observacional descriptivo (serie de casos) que incluyó a 14 niños con diagnóstico de vejiga hiperactiva neurogénica refractarios a tratamiento de primera línea sometidos a administración intravesical de toxina botulínica entre 2015 y 2021; se realizó el seguimiento teniendo en cuenta las variables clínicas, con evaluación de la respuesta y de los eventos adversos. Se reportaron frecuencias absolutas y porcentajes para las variables cualitativas; para las variables cuantitativas, se reportaron medidas de tendencia central y dispersión.
Resultados Se incluyeron 6 niños y 8 niñas, con una media de edad 10,1 (desviación estándar [DE]: ± 4,4) años. Todos los pacientes fueron tratados previamente con anticolinérgico y cateterismos limpios intermitentes, con una media de uso de 2,8 (DE: ± 1.0) pañales al día; 11 (78,5%) pacientes tenían antecedente de infección urinaria, 13 (92,8%), estreñimiento, y 2 (15,3%), incontinencia fecal. En la ecografía, 7 (50,0%) pacientes presentaban engrosamiento de las paredes vesicales, y 6 (42,8%), hidronefrosis. Tras el procedimiento, 1 paciente presentó infección urinaria como complicación, 6 presentaron una respuesta completa, 7, respuesta parcial, y 1 paciente no obtuvo respuesta con la primera inyección, con un tiempo promedio efectivo de la terapia 8 (DE: ± 6,3) meses. Una segunda inyección fue necesaria en 6 (42.8%) pacientes, y, de estos, 3 (50%) requirieron una tercera inyección.
Conclusión La inyección de toxina botulinica intravesical como terapia de segunda línea de manejo para vejiga hiperactiva neurogénica tiene buenos resultados, con bajas tasas de complicaciones.