bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROGRAMMED CELL DEATH8 interacts with tetrapyrrole biosynthesis enzymes and ClpC1 to maintain homeostasis of tetrapyrrole metabolites in Arabidopsis
Authors: Geng Rudan , Pang Xiaoqing , Li Xia , Shi Shanshan , Hedtke Boris , Grimm Bernhard , Bock Ralph , Huang Jirong , Zhou Wenbin 
Published: March 2023

Summary
Tetrapyrrole biosynthesis (TBS) is a dynamically and strictly regulated process. Disruptions in tetrapyrrole metabolism influence many aspects of plant physiology, including photosynthesis, programmed cell death (PCD), and retrograde signaling, thus affecting plant growth and development at multiple levels. However, the genetic and molecular basis of TBS is not fully understood.
We report here PCD8, a newly identified thylakoid‐localized protein encoded by an essential gene in Arabidopsis. PCD8 knockdown causes a necrotic phenotype due to excessive chloroplast damage. A burst of singlet oxygen that results from overaccumulated tetrapyrrole intermediates upon illumination is suggested to be responsible for cell death in the knockdown mutants.
Genetic and biochemical analyses revealed that PCD8 interacts with ClpC1 and a number of TBS enzymes, such as HEMC, CHLD, and PORC of TBS.
Taken together, our findings uncover the function of chloroplast‐localized PCD8 and provide a new perspective to elucidate molecular mechanism of how TBS is finely regulated in plants.
Did the COVID‐19 Pandemic Affect Fertility Desires in Australia? Understanding Why People Changed Their Attitudes towards Having a First or Additional Child
Authors: Lazzari Ester , Reimondos Anna , Gray Edith 
Published: March 2023

AbstractAn understanding of whether and how childbearing desires have been affected by the COVID‐19 pandemic is key for explaining subsequent fertility patterns and fertility behavior in general, but empirical information is still lacking. Using a quasi‐experimental cohort design and unique panel survey data collected before and after the outbreak of COVID‐19, this study examines whether childbearing desires were affected by COVID‐19 in Australia and investigates which pandemic‐related factors affected childbearing desires the most. Results show that parents who already had one child were the most likely to experience a decline in childbearing desires because of the pandemic, while childbearing desires were most stable among those who were childless. Economic and employment‐related factors did not appear to be of great relevance in predicting changes in childbearing plans. However, changes in the quality of couple relationships and of social support from family and friends were found to be of strong importance.
Examining experts' discourse in South Korea's nuclear power policy making: An advocacy coalition framework approach to policy knowledge
Authors: Nam Aerang , Weible Christopher M. 
Published: March 2023

AbstractIn disputes over public policy, public debates often hinge on the argument involving policy knowledge. One approach for studying policy knowledge is the Advocacy Coalition Framework, which theorizes that advocacy coalitions form around coherent beliefs partly about policy knowledge and invest in policy knowledge by working with expert allies. This article examines the role of academics, a type of expert, in discourse about South Korea's adversarial nuclear energy policy debates. Using Discourse Network Analyzer, we collect and analyze text from 502 South Korean newspaper articles from 2016 through 2019. We find that academics align with distinctive discourse involving policy knowledge in coalitions. However, we also show that there exist weak or inconsistent associations between some academics' centrality and the intensity of policy conflict. The findings contribute to understanding policy knowledge, the distinctive discourse of experts, and a systematic study of controversial policy making in a non‐Western country.Related ArticlesHeo, Inhye. 2022. “Energy Democratization Policy without Democratization of Policy Governance in South Korea: A Participatory Democracy Perspective.” Politics & Policy 50(4): 834–50. https://doi.org/10.1111/polp.12480.Lantis, Jeffrey S. 2019. “‘Winning’ and ‘Losing’ the Iran Nuclear Deal: How Advocacy Coalitions and Competition Shape U.S. Foreign Policy.” Politics & Policy 47(3): 464–505. https://doi.org/10.1111/polp.12299.Nowlin, Matthew C., Maren Trochmann, and Thomas M. Rabovsky. 2022. “Advocacy Coalitions and Political Control.” Politics & Policy 50(2): 201–24. https://doi.org/10.1111/polp.12458.
Political Ideology Outdoes Personal Experience in Predicting Support for Gender Equality
Authors: Sevincer A. Timur , Galinsky Cindy , Martensen Lena , Oettingen Gabriele 
Published: March 2023

Indices of gender equality provide an inconsistent picture of current gender inequality in countries with relatively high equality. We examined women's and men's subjectively perceived gender inequality and their support for gender equality in the general population and in politicians, respectively, in three countries with relatively high gender equality: the United States, the United Kingdom, and Germany (total N = 1,612). In both women's and men's perceptions, women were treated more unequally than men. However, the inequality that women perceived was larger than the inequality men perceived. Additionally, women reported they personally experience less inequality than women as a group (person‐group discrepancy). Finally, women's and men's left/liberal (vs. right/conservative) political ideology turned out to be a relatively more powerful predictor of support for gender equality than perceived personal and societal inequality. We discuss reasons for why political ideology emerged as the strongest predictor of equality support and sketch out implications for policy efforts toward promoting gender equality.
Effects of exercise interventions to reduce chemotherapy‐induced peripheral neuropathy severity: A meta‐analysis
Authors: Nuñez de Arenas‐Arroyo Sergio , Cavero‐Redondo Iván , Torres‐Costoso Ana , Reina‐Gutiérrez Sara , Lorenzo‐García Patricia , Martínez‐Vizcaíno Vicente 
Published: March 2023

ObjectivesThe two aims of this systematic review and meta‐analysis were to (1) analyze the effect of exercise on chemotherapy‐induced peripheral neuropathy (CIPN) severity and (2) determine the best type of exercise for the management of CIPN.MethodsWe systematically searched the MEDLINE, WOS, Sportdiscus, Scopus, and Cochrane databases from inception to December 2020 for experimental studies addressing the effect of exercise on CIPN severity, as measured by symptom severity (SSS) and peripheral deep sensitivity (PDS). The DerSimonian and Laird method was used to compute pooled estimates of the standardized mean differences (SMDs) and its respective 95% confidence intervals (CIs). Subgroup analyses were performed based on the types of exercise and the frequency and length of the interventions.ResultsThirteen studies were included in this meta‐analysis. In the analyses comparing exercise interventions versus controls, there was an improvement in the SSS (SMD = −0.21; 95% CI: −0.40 to −0.01; %change: −20.34%) and the PDS (SMD = 0.49; 95% CI: 0.06 to 0.91; %change: 31.64%) in favor of the intervention group. In the pre–post analyses, there was an improvement in the SSS (SMD = −0.72; 95% CI: −1.10 to −0.34; %change: −15.65%) and the PDS (SMD = 0.47; 95% CI: 0.15 to 0.79; %change:18.98%).ConclusionsThis meta‐analysis provides an overview of the evidence supporting exercise as a suitable intervention to reduce the severity of CIPN by reducing the severity of the symptoms and the peripheral deep sensitivity among patients with cancer or cancer survivors. Furthermore, sensoriomotor training and mind–body exercises appear to be more effective in reducing symptom severity, and active nerve‐specific exercises and mind–body exercises seem to be more effective in improving peripheral deep sensitivity.
Construction and analysis of knowledge graphs for multi‐source heterogeneous data of soil pollution
Authors: Li Xingchen , Zhang Jianqin , Fan Lina , Li Xinzhi , Jiang Huizhong , Lu Nan 
Published: March 2023

AbstractThe decommissioning and overall relocation of urban industrial enterprises have generated a large number of decommissioned contaminated sites, and the leftover soil pollution is gradually becoming a major problem that restricts urban green development and damages human health. Deep mining and efficient management of site soil pollution information through digitization and informatization are needed to solve these problems more accurately and efficiently. Knowledge mapping for visual analysis of relevant pathways is a forward‐looking approach in soil contamination management that does not require complex testing instruments, thus saving research manpower, time and cost. Data associated with contaminated sites come from a wide range of sources and have different structures. Through the natural language processing technology of computer, suitable methods such as entity recognition, relationship recognition and knowledge fusion are selected to extract various types of information from contaminated sites and establish semantic networks for fast targeting of soil contamination sources, thus providing a more convenient solution. In this paper, we propose a knowledge graph construction method for multi‐source heterogeneous data of contaminated sites, find sulphide contamination sources through visual analysis of knowledge graph and explore the application prospects of natural language processing techniques such as knowledge graph in contaminated site management.
A prospective assessment of the medic autologous blood transfusion skills for field transfusion preparation
Authors: Schauer Steven G. , Mancha Fabiola , Mendez Jessica , Martinez Melody A. , Jeschke Erika A. , April Michael D. , Fisher Andrew D. , Brown Derek J. , Weymouth Wells L. , Corley Jason B. , Hill Ronnie , Cap Andrew P. 
Published: March 2023

AbstractBackgroundData demonstrate the benefit of blood product administration near point‐of‐injury (POI). Fresh whole blood transfusion from a pre‐screened donor provides a source of blood at the POI when resources are constrained. We captured transfusion skills data for medics performing autologous blood transfusion training.MethodsWe conducted a prospective, observational study of medics with varying levels of experience. Inexperienced medics were those with minimal or no reported experience learning the autologous transfusion procedures, versus reported experience among special operations medics. When available, medics were debriefed after the procedure for qualitative feedback. We followed them for up to 7 days for adverse events.ResultsThe median number of attempts for inexperienced and experienced medics was 1 versus 1 (interquartile range 1–1 for both, p = .260). The inexperienced medics had a slower median time to needle venipuncture access for the donation of 7.3 versus 1.5 min, needle removal after clamping time of 0.3 versus 0.2 min, time to bag preparation of 1.9 versus 1.0 min, time to IV access for reinfusion of 6.0 versus 3.0 min, time to transfusion completion of 17.3 versus 11.0 min, and time to IV removal of 0.9 versus 0.3 min (all p < .05). We noted one administrative safety event in which an allogeneic transfusion occurred. No major adverse events occurred. Qualitative data saturated around the need for quarterly training.ConclusionsInexperienced medics have longer procedure times when training autologous whole blood transfusion skills. This data will help establish training measures of performance for skills optimization when learning this procedure.
Receipt of low titer group O whole blood does not lead to hemolysis in children weighing less than 20 kilograms
Authors: Abou Khalil Elissa , Gaines Barbara A. , Morgan Katrina M. , Spinella Philip C. , Yazer Mark H. , Triulzi Darrell J. , Leeper Christine M. 
Published: March 2023

AbstractObjectiveThe safety of Low Titer Group O Whole Blood (LTOWB) transfusion has not been well‐studied in small children.MethodsThis is a single‐center retrospective cohort study of pediatric recipients of RhD‐LTOWB (June 2016–October 2022) who weigh less than 20 kilograms. Biochemical markers of hemolysis (lactate dehydrogenase, total bilirubin, haptoglobin, and reticulocyte count) and renal function (creatinine and potassium) were recorded on the day of LTOWB transfusion and post‐transfusion days 1 and 2. Group O and non‐Group O recipients were compared.ResultsTwenty‐one children were included. Their median (interquartile range [IQR]) weight was 12 kg (12–18) with minimum 2.8 kg, and median (IQR) age was 3 years (1.75–5.00) with minimum 0.08 years (29 days old). The most common indication for transfusion was trauma (17/21; 81%). The median (IQR) volume of LTOWB transfused was 30 mL/kg (20–42). There were 9 non‐group O and 12 group O recipients. There were no statistically significant differences in the median concentrations of any of the biochemical markers of hemolysis or the renal function markers between the non‐group O and the group O recipients at any of the three time points (p > 0.05 for all comparisons). There were also no statistically significant differences in demographic parameters or clinical outcomes including 28‐day mortality, length of stay, ventilator days, and venous thromboembolism between the groups. No transfusion reactions were reported in either group.ConclusionThese data suggest LTOWB use is safe in children weighing less than 20 kg. Further multi‐center studies and larger cohorts are needed to confirm these results.
Effects of radiation exposure and storage on the energy metabolome of platelets in whole blood
Authors: Becerra Sandra C. , Christy Barbara A. , Herzig Maryanne C. , Bynum James A. , Darlington Daniel N. 
Published: March 2023

AbstractBackgroundExposure to radiation through battlefield use of nuclear weapons, terrorist attacks or accidents at nuclear power plants is a current concern for the military. Beyond the risk of exposure to personnel is the intentional or accidental irradiation of our blood banking supply system. It is unknown how large doses of ionizing radiation affect storage of blood and blood products, including platelets. The major function of platelets is clot formation which includes aggregation, shape change, vesicle release, and fibrinogen attachment; these tasks require a significant amount of energy. Here, we determine whether the ionizing radiation effects the energy metabolome of platelets in storage.Study Design and MethodsFresh whole blood from healthy volunteers was subjected to 0, 25, or 75Gy of X‐irradiation, and stored at 4°C. Platelets were isolated from stored WB at 0, 1, 7, 14, and 21 days of storage. Krebs cycle intermediates, nicotinamide adenine dinucleotides, and the tri‐, di, and mono‐ phosphorylated versions of adenosine and guanosine were extracted and measured by tandem mass spectroscopy.ResultsIrradiation at either 25Gy or 75Gy had no significant effect on the amount of any metabolite measured compared to control (0Gy). However, there was a significant fall over time in storage for most of the metabolites measured.DiscussionThese data show that irradiation at high doses has no effect on the concentration of the energy metabolome of platelets derived from whole blood stored in 4°C for up to 21 days and suggests that platelets can maintain their metabolome even after radiation exposure.
Using a Bayesian-Inference Approach to Calibrating Models for Simulation in Robotics
Authors: Unjhawala Huzaifa Mustafa , Zhang Ruochun , Hu Wei , Wu Jinlong , Serban Radu , Negrut Dan 
Published: March 2023

AbstractIn robotics, simulation has the potential to reduce design time and costs, and lead to a more robust engineered solution and a safer development process. However, the use of simulators is predicated on the availability of good models. This contribution is concerned with improving the quality of these models via calibration, which is cast herein in a Bayesian framework. First, we discuss the Bayesian machinery involved in model calibration. Then, we demonstrate it in one example: calibration of a vehicle dynamics model that has low degree-of-freedom (DOF) count and can be used for state estimation, model predictive control, or path planning. A high fidelity simulator is used to emulate the “experiments” and generate the data for the calibration. The merit of this work is not tied to a new Bayesian methodology for calibration, but to the demonstration of how the Bayesian machinery can establish connections among models in computational dynamics, even when the data in use is noisy. The software used to generate the results reported herein is available in a public repository for unfettered use and distribution.
Introducing a structured daily multidisciplinary board round to safely enhance surgical ward patient flow in the bed shortage era: a quality improvement research report
Authors: Valente Roberto , Santori Gregorio , Stanton Lorna , Abraham Ajit , Thaha Mohamed Adhnan 
Published: March 2023

Hospital bed shortage is a worldwide concern. Their unavailability has caused elective surgery cancellations at our hospital peaking in spring 2016 at over 50%. This is often due to difficult patient step-down from intensive care (ICU) and high-dependency units (HDU). In our general/digestive surgery service admitting approximately 1000 patients yearly, ward rounds were run on a consultant firm basis.We report quality improvement (ISRCTN13976096) after we introduced a structured daily multidisciplinary board round framework (SAFER Surgery R2G) adapted from the ‘SAFER patient flow bundle’ and the ‘Red to Green days’ approaches to enhance flow. We compare 2016–2017, when our framework was applied for 12 months.We used a Plan–Do–Study–Act (PDSA) methodology. Our intervention consisted in (1) systematically communicating the key care plan after the afternoon ward rounds to the nurse in charge; (2) 30’ 10:00 hours Monday-to-Friday multidisciplinary board rounds, attended daily by the senior team and weekly by hospital and site managers, revising the key care plan to aim at safe, early discharges, assessing the appropriateness of each inpatient day and tackling any cause of delay. We measured patient flow by average length of stay (LOS), ICU/HDU step-downs and operation cancellations count, monitoring safety through early 30-day readmissions. Compliance was assessed by board round attendance and staff satisfaction rate surveys.After 12 months of intervention (PDSA-1-2, N=1032), compared with baseline (PDSA-0, N=954) average LOS significantly decreased from 7.2 (8.9) to 6.3 (7.4) days (p=0.003); ICU/HDU bed step-down flow increased by 9.3% from 345 to 375 (p=0.197), surgery cancellations dropped from 38 to 15 (p=0.100). 30-day readmissions increased from 0.9% (N=9) to 1.3% (N=14)(p=0.390). Average cross-specialty attendance was 80%. Satisfaction rates were >75%, regarding enhanced teamwork and faster decisions.The SAFER Surgery R2G framework has increased patient flow in the context of an enhanced multidisciplinary approach, requiring senior staff commitment to remain sustainable.
All-cause and cause-specific mortality in a cohort of WTC-exposed and non-WTC-exposed firefighters
Authors: Singh Ankura , Zeig-Owens Rachel , Cannon Madeline , Webber Mayris P , Goldfarb David G , Daniels Robert D , Prezant David J , Boffetta Paolo , Hall Charles B 
Published: March 2023

ObjectiveTo compare mortality rates in World Trade Center (WTC)-exposed Fire Department of the City of New York (FDNY) firefighters with rates in similarly healthy, non-WTC-exposed/non-FDNY firefighters, and compare mortality in each firefighter cohort with the general population.Methods10 786 male WTC-exposed FDNY firefighters and 8813 male non-WTC-exposed firefighters from other urban fire departments who were employed on 11 September 2001 were included in the analyses. Only WTC-exposed firefighters received health monitoring via the WTC Health Programme (WTCHP). Follow-up began 11 September 2001 and ended at the earlier of death date or 31 December 2016. Death data were obtained from the National Death Index and demographics from the fire departments. We estimated standardised mortality ratios (SMRs) in each firefighter cohort versus US males using demographic-specific US mortality rates. Poisson regression models estimated relative rates (RRs) of all-cause and cause-specific mortality in WTC-exposed versus non-WTC-exposed firefighters, controlling for age and race.ResultsBetween 11 September 2001 and 31 December 2016, there were 261 deaths among WTC-exposed firefighters and 605 among non-WTC-exposed. Both cohorts had reduced all-cause mortality compared with US males (SMR (95% CI)=0.30 (0.26 to 0.34) and 0.60 (0.55 to 0.65) in WTC-exposed and non-WTC-exposed, respectively). WTC-exposed firefighters also had lower rates of all-cause mortality (RR=0.54, 95% CI=0.49 to 0.59) and cancer-specific, cardiovascular-specific and respiratory disease-specific mortality compared with non-WTC-exposed firefighters.ConclusionBoth firefighter cohorts had lower than expected all-cause mortality. Fifteen years post 11 September 2001, mortality was lower in WTC-exposed versus non-WTC-exposed firefighters. Lower mortality in the WTC-exposed suggests not just a healthy worker effect, but additional factors such as greater access to free health monitoring and treatment that they receive via the WTCHP.
Alterations to biomarkers related to long-term exposure to diesel exhaust at concentrations below occupational exposure limits in the European Union and the USA
Authors: Wong Jason YY , Blechter Batel , Bassig Bryan A , Dai Yufei , Vermeulen Roel , Hu Wei , Rahman Mohammad L , Duan Huawei , Niu Yong , Downward George S , Leng Shuguang , Ji Bu-Tian , Fu Wei , Xu Jun , Meliefste Kees , Zhou Baosen , Yang Jufang , Ren Dianzhi , Ye Meng , Jia Xiaowei , Meng Tao , Bin Ping , Hosgood H. Dean , Rothman Nathaniel , Silverman Debra T , Zheng Yuxin , Lan Qing 
Published: March 2023

BackgroundWe previously found that occupational exposure to diesel engine exhaust (DEE) was associated with alterations to 19 biomarkers that potentially reflect the mechanisms of carcinogenesis. Whether DEE is associated with biological alterations at concentrations under existing or recommended occupational exposure limits (OELs) is unclear.MethodsIn a cross-sectional study of 54 factory workers exposed long-term to DEE and 55 unexposed controls, we reanalysed the 19 previously identified biomarkers. Multivariable linear regression was used to compare biomarker levels between DEE-exposed versus unexposed subjects and to assess elemental carbon (EC) exposure-response relationships, adjusted for age and smoking status. We analysed each biomarker at EC concentrations below the US Mine Safety and Health Administration (MSHA) OEL (<106 µg/m3), below the European Union (EU) OEL (<50 µg/m3) and below the American Conference of Governmental Industrial Hygienists (ACGIH) recommendation (<20 µg/m3).ResultsBelow the MSHA OEL, 17 biomarkers were altered between DEE-exposed workers and unexposed controls. Below the EU OEL, DEE-exposed workers had elevated lymphocytes (p=9E-03, false discovery rate (FDR)=0.04), CD4+ count (p=0.02, FDR=0.05), CD8+ count (p=5E-03, FDR=0.03) and miR-92a-3p (p=0.02, FDR=0.05), and nasal turbinate gene expression (first principal component: p=1E-06, FDR=2E-05), as well as decreased C-reactive protein (p=0.02, FDR=0.05), macrophage inflammatory protein-1β (p=0.04, FDR=0.09), miR-423-3p (p=0.04, FDR=0.09) and miR-122-5p (p=2E-03, FDR=0.02). Even at EC concentrations under the ACGIH recommendation, we found some evidence of exposure-response relationships for miR-423-3p (ptrend=0.01, FDR=0.19) and gene expression (ptrend=0.02, FDR=0.19).ConclusionsDEE exposure under existing or recommended OELs may be associated with biomarkers reflective of cancer-related processes, including inflammatory/immune response.