bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cosmological constraints from HSC survey first-year data using deep learning
Authors: Lu Tianhuan , Haiman Zoltán , Li Xiangchong 
Published: March 2023

ABSTRACT
We present cosmological constraints from the Subaru Hyper Suprime-Cam (HSC) first-year weak lensing shear catalogue using convolutional neural networks (CNNs) and conventional summary statistics. We crop 19 $3\times 3\, \mathrm{{deg}^2}$ sub-fields from the first-year area, divide the galaxies with redshift 0.3 ≤ z ≤ 1.5 into four equally spaced redshift bins, and perform tomographic analyses. We develop a pipeline to generate simulated convergence maps from cosmological N-body simulations, where we account for effects such as intrinsic alignments (IAs), baryons, photometric redshift errors, and point spread function errors, to match characteristics of the real catalogue. We train CNNs that can predict the underlying parameters from the simulated maps, and we use them to construct likelihood functions for Bayesian analyses. In the Λ cold dark matter model with two free cosmological parameters Ωm and σ8, we find $\Omega _\mathrm{m}=0.278_{-0.035}^{+0.037}$, $S_8\equiv (\Omega _\mathrm{m}/0.3)^{0.5}\sigma _{8}=0.793_{-0.018}^{+0.017}$, and the IA amplitude $A_\mathrm{IA}=0.20_{-0.58}^{+0.55}$. In a model with four additional free baryonic parameters, we find $\Omega _\mathrm{m}=0.268_{-0.036}^{+0.040}$, $S_8=0.819_{-0.024}^{+0.034}$, and $A_\mathrm{IA}=-0.16_{-0.58}^{+0.59}$, with the baryonic parameters not being well-constrained. We also find that statistical uncertainties of the parameters by the CNNs are smaller than those from the power spectrum (5–24 per cent smaller for S8 and a factor of 2.5–3.0 smaller for Ωm), showing the effectiveness of CNNs for uncovering additional cosmological information from the HSC data. With baryons, the S8 discrepancy between HSC first-year data and Planck 2018 is reduced from $\sim 2.2\, \sigma$ to $0.3\!-\!0.5\, \sigma$.
Cosmological structure formation and soliton phase transition in fuzzy dark matter with axion self-interactions
Authors: Mocz Philip , Fialkov Anastasia , Vogelsberger Mark , Boylan-Kolchin Michael , Chavanis Pierre-Henri , Amin Mustafa A , Bose Sownak , Dome Tibor , Hernquist Lars , Lancaster Lachlan , Notis Matthew , Painter Connor , Robles Victor H , Zavala Jesús 
Published: March 2023

ABSTRACT
We investigate cosmological structure formation in fuzzy dark matter (FDM) with the attractive self-interaction (SI) with numerical simulations. Such a SI would arise if the FDM boson were an ultra-light axion, which has a strong CP symmetry-breaking scale (decay constant). Although weak, the attractive SI may be strong enough to counteract the quantum ‘pressure’ and alter structure formation. We find in our simulations that the SI can enhance small-scale structure formation, and soliton cores above a critical mass undergo a phase transition, transforming from dilute to dense solitons.
Epidemiological trends, prognostic factors, and survival outcomes of synchronous brain metastases from 2015 to 2019: a population-based study
Authors: Parker Megan , Jiang Kelly , Rincon-Torroella Jordina , Materi Joshua , Azad Tej D , Kamson David O , Kleinberg Lawrence R , Bettegowda Chetan 
Published: March 2023

AbstractBackgroundBrain metastases (BM) constitute a significant cause of oncological mortality. Statistics on the incidence of BM are limited because of the lack of systematic nationwide reporting. We report the incidence of synchronous brain metastases (sBM), defined as BM identified at the time of primary cancer diagnosis from 2015 to 2019 using National Cancer Institute's (NCI’s) Surveillance, Epidemiology, and End Results Program database.MethodsWe identified 1,872,057 patients with malignancies diagnosed between 2015 and 2019 from the SEER 17 Registries database, including 35,986 (1.9%) patients with sBM. Age-adjusted incidence rates were examined using the NCI Joinpoint software. Kaplan-Meier curves and a multivariate Cox regression model were used to investigate survival.ResultsThe incidence rate of sBM from 2015 to 2019 was 7.1 persons per 100,000. Lung and bronchus cancers had the highest incidence of sBM (5.18 to 5.64 per 100,000), followed by melanoma (0.30 to 0.34 per 100,000) and breast cancers (0.24 to 0.30 per 100,000). In children, renal tumors had the highest sBM incidence. sBM were associated with poorer survival than extracranial metastases only (hazard ratio [HR]: 1.40 [95% CI: 1.39–1.42], P &lt; .001). We observed better survival in white patients relative to nonwhite patients with sBM (HR: 0.91 [95% CI: 0.90–0.94], P &lt; .001).ConclusionsThe incidence rate of sBM has remained similar to rates reported over the last 9 years, with the majority associated with primary lung and bronchus cancers. sBM represent a national healthcare burden with tremendous mortality in pediatric and adult populations. This population may benefit from improved screening and treatment strategies.
The Emergence and Persistence ofCandida aurisin Western New York With No Epidemiologic Links: A Failure of Stewardship?
Authors: McGann Patrick , Lebreton Francois , Aggarwal Abhimanyu , Stam Jason , Maybank Rosslyn , Ficinski Matthew , Bronstein Melissa , Bennett Jason W , Lesho Emil 
Published: March 2023

AbstractReports of Candida auris infection in patients without epidemiologic links to prior outbreaks are scarce. We describe the genomic epidemiology of such a case in Western New York. Before emergence, the patient received &gt;60 days of excess antibiotics. Candida auris was recovered on near-patient surfaces after enhanced terminal cleanings.
The mRNA mobileome: challenges and opportunities for deciphering signals from the noise
Authors: Heeney Michelle , Frank Margaret H 
Published: March 2023

Abstract
Organismal communication entails encoding a message that is sent over space or time to a recipient cell, where that message is decoded to activate a downstream response. Defining what qualifies as a functional signal is essential for understanding intercellular communication. In this review, we delve into what is known and unknown in the field of long-distance messenger RNA (mRNA) movement and draw inspiration from the field of information theory to provide a perspective on what defines a functional signaling molecule. Although numerous studies support the long-distance movement of hundreds to thousands of mRNAs through the plant vascular system, only a small handful of these transcripts have been associated with signaling functions. Deciphering whether mobile mRNAs generally serve a role in plant communication has been challenging, due to our current lack of understanding regarding the factors that influence mRNA mobility. Further insight into unsolved questions regarding the nature of mobile mRNAs could provide an understanding of the signaling potential of these macromolecules.
Elevated methylglyoxal levels inhibit tomato fruit ripening by preventing ethylene biosynthesis
Authors: Gambhir Priya , Raghuvanshi Utkarsh , Parida Adwaita Prasad , Kujur Stuti , Sharma Shweta , Sopory Sudhir K , Kumar Rahul , Sharma Arun Kumar 
Published: March 2023

Abstract
Methylglyoxal (MG), a toxic compound produced as a by-product of several cellular processes, such as respiration and photosynthesis, is well known for its deleterious effects, mainly through glycation of proteins during plant stress responses. However, very little is known about its impact on fruit ripening. Here, we found that MG levels are maintained at high levels in green tomato (Solanum lycopersicum L.) fruits and decline during fruit ripening despite a respiratory burst during this transition. We demonstrate that this decline is mainly mediated through a glutathione-dependent MG detoxification pathway and primarily catalyzed by a Glyoxalase I enzyme encoded by the SlGLYI4 gene. SlGLYI4 is a direct target of the MADS-box transcription factor RIPENING INHIBITOR (RIN), and its expression is induced during fruit ripening. Silencing of SlGLYI4 leads to drastic MG overaccumulation at ripening stages of transgenic fruits and interferes with the ripening process. MG most likely glycates and inhibits key enzymes such as methionine synthase and S-adenosyl methionine synthase in the ethylene biosynthesis pathway, thereby indirectly affecting fruit pigmentation and cell wall metabolism. MG overaccumulation in fruits of several nonripening or ripening-inhibited tomato mutants suggests that the tightly regulated MG detoxification process is crucial for normal ripening progression. Our results underpin a SlGLYI4-mediated regulatory mechanism by which MG detoxification controls fruit ripening in tomato.
An active microbiome in Old Faithful geyser
Authors: Keller Lisa M , Colman Daniel R , Boyd Eric S 
Published: March 2023

Abstract
Natural thermal geysers are hot springs that periodically erupt liquid water, steam, and gas. They are found in only a few locations worldwide, with nearly half located in Yellowstone National Park (YNP). Old Faithful geyser (OFG) is the most iconic in YNP and attracts millions of visitors annually. Despite extensive geophysical and hydrological study of geysers, including OFG, far less is known of the microbiology of geysed waters. Here, we report geochemical and microbiological data from geysed vent water and vent water that collects in a splash pool adjacent to OFG during eruptions. Both waters contained microbial cells, and radiotracer studies showed that they fixed carbon dioxide (CO2) when incubated at 70°C and 90°C. Shorter lag times in CO2 fixation activity were observed in vent and splash pool waters incubated at 90°C than 70°C, suggesting cells are better adapted or acclimated to temperatures like those in the OFG vent (∼92–93°C). 16S rDNA and metagenomic sequence data indicated that both communities are dominated by the autotroph Thermocrinis, which likely fuels productivity through the aerobic oxidation of sulfide/thiosulfate in erupted waters or steam. Dominant OFG populations, including Thermocrinis and subdominant Thermus and Pyrobaculum strains, exhibited high-strain level genomic diversity (putative ecotypes) relative to populations from nongeysing YNP hot springs that is attributed to the temporal chemical and temperature dynamics caused by eruptions. These findings show that OFG is habitable and that its eruption dynamics promote genomic diversity, while highlighting the need to further research the extent of life in geyser systems such as OFG.
The Devil No More? Decreasing Negative Outparty Affect through Asymmetric Partisan Thinking
Authors: Marsh Wayde Z C 
Published: March 2023

Abstract
Political scientists, party elites, and journalists agree that affective polarization and negative partisanship are serious problems in American politics, but is it possible to reverse this trend and decrease negative outparty affect? Using two original survey experiments that manipulate partisans to think of the Republican and Democratic parties in either expressive or instrumental terms, I find that providing policy information about the parties decreases Republicans’ negative affect toward Democrats, while providing party coalition information decreases Democrats’ negative affect toward Republicans. Neither type of information, however, causes a significant change in inparty affect. This paper provides evidence, therefore, that an asymmetric informational intervention can decrease negative outparty affect, with important implications for an affectively polarized America.
Overreaction in Expectations: Evidence and Theory
Authors: Afrouzi Hassan , Kwon Spencer Y , Landier Augustin , Ma Yueran , Thesmar David 
Published: March 2023

Abstract
We investigate biases in expectations across different settings through a large-scale randomized experiment where participants forecast stable stochastic processes. The experiment allows us to control forecasters’ information sets as well as the data-generating process, so we can cleanly measure biases in beliefs. We report three facts. First, forecasts display significant overreaction to the most recent observation. Second, overreaction is stronger for less persistent processes. Third, overreaction is also stronger for longer forecast horizons. We develop a tractable model of expectations formation with costly processing of past information, which closely fits the empirical facts. We also perform additional experiments to test the mechanism of the model.
Effectiveness of online trainings on radiation protection in the context of the COVID-19 pandemic
Authors: Kiparoidze Salome , Nadareishvili Davit , Jariashvili Ketevan , Astamadze Nino 
Published: March 2023

Abstract
Over 212 healthcare professionals from the country have used the online trainings on radiation protection conducted during the COVID-19 pandemic. Each training, lasting up to 10 working days, is accompanied by mandatory Google Form-based questionnaires, which includes topic key questions about each lecture as well as pre- and post-training tests and provided to participants. In addition, the ability to conduct a dialogue with patients about radiation risks, group discussions, as well as a special module for radiation protection officers were assessed online. The trainings also allow participants to focus on the most important issues from their point of view in their daily work, indicating them in pre-tests, allowing the trainers to conduct lectures more adequately for each group of participants. Analysis of the tests have shown that online training is not inferior in efficiency to face-to-face training and national regulatory body received an improved opportunity to indirectly assess this efficiency.
Dosimetry using a radiochromic film and a mammography phantom
Authors: Gotanda Tatsuhiro , Kawaji Yasuyuki , Yatake Hidetoshi , Imai Shinya , Akagawa Takuya , Katsuda Toshizo 
Published: March 2023

Abstract
Mammography is one of the most effective diagnostic methods for the early detection of breast cancer; however, it poses the risk of radiation exposure. To date, mammography dosimetry has been performed according to the mean glandular dose; however, the actual exposure in the breast has not been assessed. Here, we have measured dose distributions and depth doses using both radiochromic films and mammographic phantoms, and a three-dimensional intra-mammary dose assessment was conducted. The absorbed dose distribution at the surface was markedly higher on the chest wall side but lower on the nipple side. The absorbed doses in the depth direction exponentially decreased. The glandular tissue near the surface may be irradiated with an absorbed dose of 7.0 mGy or higher. Since LD-V1 could be placed inside the phantom, the absorbed dose inside the breast could also be evaluated in three dimensions.
Voluntary or reluctant? Social influence in charitable giving: an ERP study
Authors: Xu Qiang , He Shengnan , Li Zhurong , Duan Ran , Li Peng 
Published: March 2023

AbstractSocial information has substantial influences on prosocial behavior. In this study, we performed an event-related potential (ERP) experiment to examine the effect of social influence on giving. The participants were allowed to form an initial decision on how much money to donate to a charity provided the program’s average donation amount and to make a second donation decision. Social influence varied in different directions (upward, downward and equal) by altering the relative donation amount between the average donation amount and the participants’ first donation amount. The behavioral results showed that participants increased their donation amount in the upward condition and decreased it in the downward condition. The ERP results revealed that upward social information evoked larger feedback-related negativity (FRN) amplitudes and smaller P3 amplitudes than in the downward and equal conditions. Furthermore, the pressure ratings, rather than the happiness ratings, were associated with the FRN patterns across the three conditions. We argue that people in social situations are more likely to increase their donations owing to pressure than voluntary altruism. Our study provides the first ERP evidence that different directions of social information evoke different neural responses in time course processing.
Influence of level of dried distillers grains plus solubles substitution for steam-flaked corn on characteristics of growth performance, and dietary energetics of calf-fed Holstein steers during the initial 16-week growing phase: metabolizable protein versus metabolizable amino acids
Authors: Montano Martin F , Carvalho Pedro H V , Ferraz Junior Marcos V C , Latack Brooke C , Zinn Richard A 
Published: March 2023

Abstract
This study evaluates the partial replacement of steam-flaked corn (SFC) with increasing dried distillers grains plus solubles (DDGS) levels in growing-finishing diets for calf-fed Holstein steers. Two experiments were conducted. In trial 1, 100 Holstein calves (136 ± 7 kg) were used to evaluate the effect of DDGS as a metabolizable protein source on cattle growth performance, and dietary energetics of calf-fed Holstein steers during the initial 111 d growing phase. Four dietary levels of DDGS were evaluated (10, 15, 20, and 25%, dry matter basis), replacing SFC (flake density, 0.31 kg/L). In trial 2, four Holstein steers (368 ± 20 kg) with cannulas in the rumen and proximal duodenum were used to evaluate treatment effects on characteristics of ruminal and total tract digestion of organic matter (OM), neutral detergent fiber, nitrogen (N), and indispensable amino acid supply to the small intestine. The increasing level of DDGS did not affect (P ≥ 0.13) average daily gain, gain efficiency, and estimated dietary net energy values. Replacement of SFC with increasing levels of DDGS decreased (linear; P = 0.01) ruminal OM digestion. There was no treatment effect on the flow of microbial nitrogen to the small intestine (P = 0.34) and ruminal microbial efficiency (P = 0.79). However, increasing levels of DDGS in the diet increased (linear; P ≤ 0.04) flow of methionine, histidine, phenylalanine, threonine, leucine, isoleucine, and valine but did not affect (P = 0.74) intestinal supply of lysine. Increasing DDGS in the diet increased (linear, P &lt; 0.01) flow of N to the small intestine but decreased (linear; P &lt; 0.01) ruminal N efficiency. Replacing SFC with DDGS increased intake and amino acid leaving the abomasum. Still, this effect was not sufficient to increase the growth performance of calf-fed Holstein during the first 111 d on feed.
Nursing Students' Scenario Performance
Authors: Koivisto Jaana-Maija , Havola Sara , Engblom Janne , Buure Tuija , Rosqvist Kristiina , Haavisto Elina 
Published: March 2023

Abstract

AIM
The purpose of this study was to examine nursing students' scenario performance in a simulation game by utilizing game metrics.

BACKGROUND
A significant advantage of simulation games is that they can store large amounts of data. Although game metrics enable the objective evaluation and analysis of performance, their use in the evaluation of students' performance is limited.

METHOD
Nursing students (N = 376) played a simulation game at home for 1 week. The resulting data consisted of game metrics stored in the game: number of playthroughs, mean scores, and mean playing times.

RESULTS
The total number of playthroughs was 1,923. Statistically significant differences were found between different scenarios regarding the mean score (p < .0001). Mean playing time was significantly associated with the mean score (p < .05).

CONCLUSION
Game metrics demonstrate nursing students' scenario performance in clinical reasoning skills in different scenarios in a simulation game.
Recall patterns and risk of primary liver cancer for subcentimeter ultrasound liver observations: a multicenter study
Authors: Singal Amit G. , Ghaziani T. Tara , Mehta Neil , Zhou Kali , Grinspan Lauren T. , Benhammou Jihane N. , Moon Andrew M. , Yang Ju Dong , Salgia Reena , Pillai Anjana , Zheng Elizabeth , Rich Nicole E , Gopal Purva , Jalal Prasun , Verna Elizabeth , Yekkaluri Sruthi , Phen Samuel , Melendez-Torres Jonathan , Alshuwaykh Omar , Choi Hailey , Junus Kevin , Grady John , Song Michael , Leven Emily A. , Yum Jung , Gowda Vrushab , Alsudaney Manaf , Hernandez Perla , Desai Nirmal , Parikh Neehar D. 
Published: March 2023

Background:
Patients with cirrhosis and subcentimeter lesions on liver ultrasound are recommended to undergo short-interval follow-up ultrasound because of the presumed low risk of primary liver cancer (PLC).

Aims:
The aim of this study is to characterize recall patterns and risk of PLC in patients with subcentimeter liver lesions on ultrasound.

Methods:
We conducted a multicenter retrospective cohort study among patients with cirrhosis or chronic hepatitis B infection who had subcentimeter ultrasound lesions between January 2017 and December 2019. We excluded patients with a history of PLC or concomitant lesions ≥1 cm in diameter. We used Kaplan Meier and multivariable Cox regression analyses to characterize time-to-PLC and factors associated with PLC, respectively.

Results:
Of 746 eligible patients, most (66.0%) had a single observation, and the median diameter was 0.7 cm (interquartile range: 0.5–0.8 cm). Recall strategies varied, with only 27.8% of patients undergoing guideline-concordant ultrasound within 3–6 months. Over a median follow-up of 26 months, 42 patients developed PLC (39 HCC and 3 cholangiocarcinoma), yielding an incidence of 25.7 cases (95% CI, 6.2–47.0) per 1000 person-years, with 3.9% and 6.7% developing PLC at 2 and 3 years, respectively. Factors associated with time-to-PLC were baseline alpha-fetoprotein >10 ng/mL (HR: 4.01, 95% CI, 1.85–8.71), platelet count ≤150 (HR: 4.90, 95% CI, 1.95–12.28), and Child-Pugh B cirrhosis (vs. Child-Pugh A: HR: 2.54, 95% CI, 1.27–5.08).

Conclusions:
Recall patterns for patients with subcentimeter liver lesions on ultrasound varied widely. The low risk of PLC in these patients supports short-interval ultrasound in 3–6 months, although diagnostic CT/MRI may be warranted for high-risk subgroups such as those with elevated alpha-fetoprotein levels.
Hybrid and Traditional Cardiac Rehabilitation in a Rural Area
Authors: Williamson-Reisdorph Cassie M. , Larson Whitney T. , Porisch Laura B. , Quindry John C. 
Published: March 2023

Purpose:
Cardiac rehabilitation is a prescribed exercise intervention that reduces cardiovascular mortality, secondary events, and hospitalizations. Hybrid cardiac rehabilitation (HBCR) is an alternative method that overcomes barriers to participation, such as travel distance and transportation issues. To date, comparisons of HBCR and traditional cardiac rehabilitation (TCR) are limited to randomized controlled trials, which may influence outcomes due to supervision associated with clinical research. Coincidental to the COVID-19 pandemic, we investigated HBCR effectiveness (peak metabolic equivalents [peak METs]), resting heart rate (RHR), resting systolic (SBP) and diastolic blood pressure (DBP), body mass index (BMI), and depression outcomes (Patient Health Questionnaire-9 [PHQ-9]).

Methods:
Via retrospective analysis, TCR and HBCR were examined during the COVID-19 pandemic (October 1, 2020, and March 31, 2022). Key dependent variables were quantified at baseline (pre) and discharge (post). Completion was determined by participation in 18 monitored TCR exercise sessions and four monitored HBCR exercise sessions.

Results:
Peak METs increased at post-TCR and HBCR (P < .001); however, TCR resulted in greater improvements (P = .034). The PHQ-9 scores were decreased in all groups (P < .001), while post-SBP and BMI did not improve (SBP: P = .185, BMI: P = .355). Post-DBP and RHR increased (DBP: P = .003, RHR: P = .032), although associations between intervention and program completion were not observed (P = .172).

Conclusions:
Peak METs and depression metric outcomes (PHQ-9) improved with TCR and HBCR. Improvements in exercise capacity were greater with TCR; however, HBCR did not produce inferior results by comparison, an outcome that may have been essential during the first 18 mo of the COVID-19 pandemic.