bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of hemoadsorption with CytoSorb® on meropenem and piperacillin exposure in critically ill patients in a post-CKRT setup: a single-center, retrospective data analysis
Authors: Asgarpur Golschan , Weber Franz , Kiessling Peggy , Akbari Nilufar , Stroben Fabian , Kleikamp Bernadette , Kloft Charlotte , Treskatsch Sascha , Angermair Stefan 
Published: January 2025

Abstract

Purpose
CytoSorb® (CS) adsorbent is a hemoadsorption filter for extracorporeal blood purification often integrated into continuous kidney replacement therapy (CKRT). It is primarily used in critically ill patients with sepsis and related conditions, including cytokine storms and systemic inflammatory responses. Up to now, there is no evidence nor recommendation for the use of CS filters in sepsis (22). There is limited clinical data on the effect of CS on the plasma concentrations of beta-lactams. We aimed to evaluate the statistical and clinical impact of CS in a post-filter CKRT-CS setting on the plasma concentrations of the antibiotics meropenem and piperacillin in critically ill patients.

Methods
Patients admitted to the intensive care unit (ICU) who received a prolonged infusion of piperacillin or meropenem with CS-combined CKRT were included in this retrospective analysis. TDM (therapeutic drug monitoring) plasma blood samples were collected at three different points. The differences in antibiotic concentrations between Pre, Intra, and Post were statistically compared to evaluate the total and isolated contributions of CKRT and CS to antibiotic removal. CS, CKRT and combined clearance (CL) values were calculated. The hypothesis was that the CS filter would have no clinically relevant impact on antibiotic levels.

Results
207 TDM samples were taken from 24 critically ill patients requiring beta-lactam antibiotics. Among these, 129 were meropenem samples, and 78 were piperacillin samples. A decrease in both antibiotic levels was observed between Pre and Intra, and Pre and Post, and the median relative difference between was >15% (meropenem: Pre–Intra 34.8%, Pre–Post 35.8%; piperacillin: Pre–Intra 41.1%, Pre–Post 34.7%), indicating a statistically and clinically significant effect of CKRT on both antibiotic exposures. No significant difference was observed between Intra and Post indicating no clinically relevant drug removal via the CS filter. Changes in CL attributed to CS were minimal, with combined CL differing by ≤8.60% compared to CKRT clearance.

Conclusion
The application of CS does not appear to significantly affect plasma concentrations of meropenem and piperacillin in critically ill patients.
Analysis of stiffness changes and factors induced by smart suit with trunk kinetic chain SLIP model
Authors: Mori Hiromu , Tanaka Takayuki , Murai Akihiko , Kusaka Takashi , Imamura Yumeko 
Published: January 2025

Abstract
We are currently developing a suit that assists human running motion based on the Smart Suit (SS). The SS is a wearable assistive device that intervenes in trunk kinetic chain movements by linking trunk rotation to hip flexion and extension through elastic belts. By intervening in the trunk kinetic chain, our goal is to enhance stiffness, thereby improving running economy and speed. The purpose of this study is to acquire fundamental insights into the changes in leg and trunk rotational stiffness induced by the SS, as well as the underlying mechanisms. We defined the SS torque intervention rate

$$p_{ss}$$

p

ss

, which focuses on the magnitude of force, and the peak time difference index,

$$e_{lag}$$

e

lag

, between SS and humans, which focuses on the timing of force, and analyzed the relationship between the stiffness change rate due to SS wearing. The results of the analysis suggest that SS affects human running sensitively rather than mechanically. We also confirmed that the degree of adaptation to SS, assessed by the timing gap between SS exertion and human exertion, contributes significantly to changes in trunk rotation stiffness.
Tinkerers, learning organisations and sustainable innovation
Authors: Wilmott Deirdre 
Published: January 2025

The contribution of the lone ranger educator who tinkers with applications, testing discarding and working haphazardly around systems, should be seriously considered. Whilst learning organisations want to be perceived as dynamic structures that recognise and support innovation in curriculum and teaching practice they cannot responsibly incorporate every technical change, new invention or application, and idea into their curriculum.
Collaborative teams concerned with responsible sustainability, should not be subjecting their ideas to natural selection. Before ideas can be disseminated through collective teams, there needs to be a diffusion of originality, innovation and thought between members of teams, and this frequently stems from the very tinkerers whose willingness to take risks and fail with new technologies is often regarded as inefficient and contradictory to organisational development.

As learning organisations embed open source and community developed software, they are finding themselves enmeshed with systems that are never complete and always being changed as the Internet magnifies the opportunities for tinkerers to adapt applications.
When learning organisations embrace the open source option instead of using proprietary licences, they too have an obligation to support and participate in the development. This development is often done within a community that exists without concerns for sustainability and responsibility but uses an adaptive process of natural selection. An important way in which they can respond to this obligation is to provide an environment where lone rangers tinkering in the developmental role of resources can function.
Analysis of gradual diameter thrombectomy stent in vitro
Authors: Shen Caifeng , Ma Zhenjian , Li Hong , Wei Ming 
Published: January 2025

Abstract

Objective
To analyze the effect of gradient thrombectomy stent in vitro.

Methods
The cerebrovascular fluid circulation model was made and fixed on the test table. About 0.9% sodium chloride injection was injected to the vascular model through a miniature water pump to circulate it. Four kinds of thrombus products containing different red blood cell (RBC) volumes of 0, 5, 40, and 80% were placed at the target location as thrombus. Each type of thrombus was removed five times using SOLITAIRE stent and gradient thrombectomy stent. The thrombectomy effects were observed by comparison of the two types of stents.

Results
Thrombus containing 80% volume of RBC escaped thrombus fragments during thrombectomy with both stents. Thrombus containing 0% volume of RBC (rich in fibrin) had poor chimerism with stents. In the thrombus containing 0% RBC volume, there was no statistically significant difference between the two stents (p = 1). Thrombus removal was successful in all cases.

Conclusion
The gradient thrombectomy stent is as effective as the currently used thrombectomy stent in vitro studies, and there is much room for improvement.
МАСШТАБНЫЕ ФАКТОРЫ В ГЕОМЕХАНИКЕ
Authors: АМУСИН Б.З. 
Published: January 2025

Рассмотрены ограничения традиционных методов классификации массивов горных пород. Предложена модификация условия прочности Хука - Брауна, в котором прочность на сжатие массива горных пород представлена в явном виде. Подход к оценке этой прочности сделан на основе обобщения результатов экспериментов Кима на моделях блочных структур из эквивалентных материалов. Описан подход для определения масштабных факторов прочности, модуля деформации, ползучести и угла внутреннего трения массива горных пород. Введена постоянная ползучести и получены корреляционные зависимости для ее нахождения для четырех типов пород. Установлено, что отношение смещений на контуре выработки к смещениям в зоне пластических деформаций может быть аппроксимировано функцией, зависящей только от угла внутреннего трения. Эта концепция использована для вычисления угла внутреннего трения породного массива на основе анализа полевых измерений. Выдвинуты две гипотезы и сделана попытка их обоснования. Гипотеза A предполагает, что масштабный фактор при подобной структуре массива зависит от прочности на сжатие, причем меньшие значения масштабных факторов характерны для прочных и хрупких пород по сравнению с пластичными породами меньшей прочности. Гипотеза B предполагает, что продолжительность релаксации напряжений и деформаций ползучести растет с увеличением рассматриваемого объема массива горных пород, а скорость деформаций при этом убывает.
The limitations of traditional methods of rock mass classification are reviewed. A modification is proposed for the Hoek-Brown failure criterion, with the compression strength of rocks presented in an explicit form. An approach to the compression strength assessment is taken on the ground of generalized results obtained by Kim in experiments with model block structures made of equivalent materials. An approach to determination of scale effects on strength, deformation modulus, creep and internal friction angle is described. The constant of creep is introduced, and the correlation dependences are obtained to find the creep constant in four types of rocks. It is found that the ratio of displacement at the boundary of a mine opening to displacements in the plastic strain zone can be approximated by a function of the internal friction angle only. This concept is used to calculate internal friction angles in rocks from the analysis of field measurements. The author puts forward two hypotheses and makes an attempt to substantiate them. Hypothesis A supposes that a scale effect in similar structure rock mass depends on the compression strength, and weaker scale effects are typical of hard and brittle rocks as against softer and plastic rocks. Hypothesis B supposes that time of stress and strain relaxation increases in a larger rock mass volume while the strain rate decreases.
ПОВЕРХНОСТЬ ПОТЕНЦИАЛЬНОГО СКОЛЬЖЕНИЯ И ТРАЕКТОРИЯ РАЗРУШЕНИЯ КРИТИЧЕСКИХ ЭЛЕМЕНТОВ БОРТА СО СЛАБЫМ ПРОСЛОЕМ
Authors: ЛЮ Ш. , ЧЖАО Х. , ЦЗИН Ш. , ВАН Т. 
Published: January 2025

Для угольного разреза Hequ, находящегося в провинции Шаньси Китая, с помощью мониторинга найдено расположение слабого прослоя в массиве борта. С целью изучения механизма скольжения борта со слабым прослоем построена трехмерная численная модель, рассмотрены поверхность потенциального скольжения и критические силовые элементы. Поверхность потенциального скольжения установлена на основе изучения изолиний смещений и максимального приращения деформаций сдвига. Предложен принцип выявления критических элементов массива борта со слабым прослоем. Определен главный критический элемент поверхности потенциального скольжения и траектория динамического разрушения критических элементов.
To investigate the slip mechanism of the slope with weak interlayer, the location of the weak interlayer within the slope was determined by on-site monitoring using the Hequ open pit mine as the engineering background, and a three-dimensional numerical model was established based on this, and the study of the potential slip surface and key units of the slope containing weak interlayer was carried out. The potential slip surface inside the slope with weak interlayers is determined from the perspective of displacement contour and maximum shear strain increment. The principle and method of key unit identification for the slope with weak interlayer is proposed. The initial key unit on the potential slip surface of the slope with weak interlayers is identified, and the dynamic breaking path of the key unit on the potential slip surface of the slope with weak interlayers is determined.
РАЗРАБОТКА ТЕХНОЛОГИИ КОМПЛЕКСНОЙ ПЕРЕРАБОТКИ ЭВДИАЛИТОВОГО КОНЦЕНТРАТА
Authors: ЧАНТУРИЯ В.А. , МИНЕНКО В.Г. , КОЖЕВНИКОВ Г.А. , САМУСЕВ А.Л. 
Published: January 2025

Разработана ресурсосберегающая и энергоэффективная технология комплексной переработки эвдиалитового концентрата. Установлено, что основные потери ценных компонентов (Zr и РЗЭ) связаны с кеком выщелачивания. Определены эффективные методы и рациональные режимы переработки продуктивного раствора, гарантирующие высокое извлечение Zr и РЗЭ за счет переработки образующегося силикагеля, организации последовательного выделения из продуктивного раствора фосфата циркония и карбонатов РЗЭ. Предложены дополнительные способы регенерации реагентов и схемы закрытия водяных контуров, обеспечивающие итоговое извлечение циркония и редкоземельных элементов из эвдиалитового концентрата. Разработанная технология позволяет получить дополнительную товарную продукцию (метасиликат натрия и аммиачную селитру), а также обеспечивает экономическую целесообразность и повышает экологическую безопасность переработки эвдиалитового концентрата за счет регенерации карбоната кальция.
The authors developed a resource-saving and energy-efficient technology for integrated processing of eudialyte concentrate. It is found that the main losses of valuable components (Zr and REE) are associated with leaching cake. The effective methods and modes of processing of pregnant solution are determined to ensure high recovery of Zr and REE owing to conversion of silica gel and thanks to successive extraction of zirconium phosphate and rare earth carbonates from pregnant solution. The proposed complimentary methods of regeneration of reagents and shutting off of water circuits ensure recovery of zirconium and rare earths from eudialyte concentrate. The developed technology provides additional marketable products (sodium metasilicate and ammonium nitrate), as well as economic expediency and improved ecological safety of eudialyte concentrate processing due to regeneration of calcium carbonate.
Transformaciones de la Escuela Rural en confinamiento por Covid-19: Educación, Comunicación y Cultura
Authors: Guayara Ramírez Mauren Andrés 
Published: January 2025

Los cambios en la escuela rural bajo el contexto del confinamiento por pandemia de Covid-19 tienen incidencia directa en la cultura escolar que se vio alterada por unas transformaciones en estudiantes, docentes y padres de familia, de los espacios, los tiempos, los lugares de encuentro, los rituales escolares y las practicas educativas, lo cual generó una cantidad de dificultades con variaciones de la gestión pedagógica.
El motivo de la investigación es analizar las transformaciones educativas, comunicativas y culturales vividas en la escuela rural durante el desarrollo de la actividad escolar en el contexto del confinamiento por pandemia de Covid-19 para los años 2019 al 2021.
El estudio se ubicó bajo un paradigma teórico interdisciplinario y el desarrollo de la investigación giró en torno a la metodología de investigación cualitativa en educación; como estrategia metodológica se utilizó el estudio de caso de una institución rural. Como técnicas de recolección de datos se utilizaron grupos focales y revisión documental.
Los resultados muestran los cambios más significativos vividos en la escuela, en la casa y con los amigos durante el confinamiento, evidenciando una escuela semi desconectada con alteraciones de las prácticas educativas y las formas de comunicarse que tiene incidencia en la cultura escolar.
Entre las conclusiones se evidencia que la escuela tradicional rural paso a ser una escuela arrinconada donde los actores, las prácticas y los procesos fueron retados a transformarse y adaptarse, que usaba la tecnología de manera intermitente y que la gestión pedagógica realizada estuvo limitada a los recursos existentes pero que no fue suficiente para cumplir con su misión.
“DANÇAR” E EXISTIR: RELAÇÕES ENTRE A EXTENSÃO UNIVERSITÁRIA E MULHERES DE NOVO HAMBURGO-RS
Authors: Da Silva Pinto Aline , Dorr Nicole Gabriele , Ganzer Duarte Danuse Gabriele 
Published: January 2025

Este relato tem o intuito de apresentar o Projeto Dançar, projeto de extensão da Universidade Feevale, na cidade de Novo Hamburgo-RS, desdobrando as significações construídas acerca da dança por um grupo de mulheres idosas. Esse grupo conta com 32 participantes no ano de 2024, com idades de 62 a 88 anos. Temos como problemática: O que a dança significa para as mulheres "envelhescentes" do Projeto Dançar? Para responder a essa indagação partimos das premissas da pesquisa qualitativa, por meio de roda de conversa e observações, registradas em diários de campo. Durante os caminhos dialógicos que trilhamos, percebemos que as diferentes vivências dessas mulheres, nas normativas histórico-sociais que permearam seu desenvolvimento, transformam suas formas de compreender e de viver a dança.
Physical Quality Test Of Rice Bran From Different Milling In Tanah Laut District
Authors: Maulana Fajri , Fajri Fadhli , Febrina Bunga Putri , Sandri Dwi 
Published: January 2025

This research aims to determine the physical quality of rice bran from different mills in Tanah Laut Regency. Data were collected in this research by means of observation and interviews at five different mills in Tanah Laut, namely Panyipatan, Bumi Makmur, Takisung, Kurau and Pelaihari Districts. Data collection was continued with analysis of the physical quality of the bran in the laboratory. Data was processed manually and analyzed descriptively. The parameters measured for the physical quality of rice bran are water content, pile density, pile compaction density, pile angle and specific gravity. The results of this research show that the physical quality of rice bran from different mills in Tanah Laut Regency has good criteria in terms of water content, namely: 11.18 – 13.31%; stack density 300.00 - 430.00 gram/cm3; pile compaction density 395.04 - 693.45 gram/cm33; stack angle 32.09 - 53.85° and specific gravity 0.219 - 0.143 gram/cm3.
Genetic Quality Improvement of Beef Cattle in Indonesia: Overview and Prospects
Authors: Rahmatillah Ririn Siti , Rahmat Dedi , Dudi Dudi 
Published: January 2025

Technology for Improving the genetic quality of beef cattle is a key factor in the development of the livestock industry in Indonesia. In recent decades, efforts have been made to improve beef cattle’s genetic quality through breeding and modern reproductive technologies. The journal aims to present an in-depth understanding of the efforts made to improve the genetic quality of beef cattle in Indonesia and to explain prospects in terms of breeding and reproductive technology. This article is based on reflections on recent literature and research in this field..
Korkeamman asteen automaation käyttöönotto yliopistollisen keskussairaalan hematologisessa laboratoriossa
Authors: Björkqvist Stig , Kekoni Jaakko , Penttilä Ilkka , Kentta Erkki 
Published: January 2025

Tutkimuksen tarkoituksena oli verrata kahden perusverenkuvaa (pvk) automaattisesti analysoivan laitteen taloudellisuutta Kuopion yliopistollisen keskussairaalan (KYKS) laboratoriossa. Coulter Counter S - IV (CC-IV) on käsisyöttöinen n. 0,5 milj. mk maksava automaatti ja Coulter Counter S + Stacker (STKR) 1,15 milj. mk maksava analysaattori, jossa on automaattinen näytteen syöttö. Koneiden käyttöä seurattiin kymmenen arkipäivän ajan. Kustannuksiin laskettiin mukaan vain välittömät verinäytteiden analysointiin käytetyt voimavarat sekä laitteiden pääomakustannukset. Atk-kustannuksia ei otettu laskelmiin mukaan. Vertailu osoitti, että STKR on KYKS:n perusverenkuvan kysyntätasolla (jopa 450 analyysia/päivä) selvästi CCA-IV taloudellisempi. STKR:n hinta säästyy muihin tehtäviin vapautuneen työvoiman palkkakustannuksissa alle kahdessa vuodessa, kun laitteiden toimintakestävyys on arvioitu seitsemän vuotta.
Psykiatriset päivystyspotilaat yleissairaalassa
Authors: Viinamäki Heimo , Lehtonen Johannes , Väänänen Kyösti 
Published: January 2025

Tutkimuksessa arvioitiin yleissairaalassa tehtyjen psykiatristen päivystyskonsultaatioiden potilasjakautumaa ja tarpeellisuutta. Aineistoon otettiin 100 ensimmäistä psykiatrista päivystyskonsultaatiota vuoden 1987 alusta, mikä vastasi noin 25 % vuoden kaikista konsultaatioista. Kaikki tiedot saatiin retrospektiivisesti sairauskertomuksista.
Psykoosi tai psykoositasoinen häiriö todettiin 25 %:lla ja rajatila- tai rajatilatasoinen häiriö 26 %:lla. Tutkimuksen keskeytti 27 % potilaista, mutta siihen mennessä saatujen tietojen perusteella näistä 40 %:lla näytti olevan vaikea psyykkinen häiriö (rajatila tai psykoosi). Valtaosa (70 %) konsultoiduista potilaista tuli ensimmäistä kertaa psykiatrisen tutkimuksen ja hoidon piiriin. Psykoottisia oli näistä 20 % ja rajatilatasoisesti oireilevia 16 %. Niistä potilaista, joita oli konsultoitu jo aiemmin, oli psykoottisia 32 % ja rajatilatasoisesti oireilevia 47 %. Pitkäaikainen somaattinen sairaus oli 37 %:lla kaikista aineiston potilaista.
Tutkimuksen perusteella arvioituna psykiatriset päivystyskonsultaatiot ovat välttämättömiä. Suurimmalle osalle potilaista se tarjoaa ensimmäisen tilaisuuden psykiatriseen kontaktiin. Potilaiden häiriintyneisyyden asteen vuoksi psykiatrisen avun tarve oli ilmeinen. Havaintomme korostavat näin ollen yleissairaalan merkitystä kriisiluonteisen psykiatrisen avun antajana. Osa väestöstä ei käänny mielenterveysongelmiensa vuoksi välttämättä ensisijaisesti mielenterveysorganisaation puoleen, vaan päätyy psykiatrisiin tutkimuksiin vasta somaattisen sairauden tehtyä sen välttämättömäksi.
Synergy-based motor therapy for post-stroke hemiparetic subjects: A randomized controlled trial
Authors: Pandian Shanta , Sharma Raj Kumar , Dwivedi Amit 
Published: January 2025

Objectives:
Motor recovery is inclusively based on the severity of abnormal coupling or the abnormal synergistic actions among the post-stroke hemiparetic subjects. The normal synergistic pattern shall be incorporated to inhibit the abnormal synergistic behavior to attain motor control.

Materials and Methods:
A randomized controlled double blinded (assessor and subjects) trial was conducted in a rehabilitation institute. One hundred and thirty-six post-stroke (mean duration, 12.73 ± 9.52 months) hemiparetic subjects were conveniently selected and randomly allocated in two groups (experimental, 68 and control, 68). The experimental group received synergistic-based motor therapy (SBMT) protocol and the control group of the subjects received the conventional occupational therapy intervention. Both of the groups received dose-matched intervention for the period of 3 months, 48 sessions (4/week). Normal synergistic linkage was being exploited to encounter the abnormal synergistic patterns. The main outcome measures were Fugl-Meyer Assessment – upper extremity (FMA-UE), arm (FMA-A), wrist-hand (FMA-WH) for the motor recovery and Finger Breadth Palpation method (FBP) for the shoulder subluxation.

Results:
In comparison to the control group, the experimental group exhibited highly significant results. The mean score of FMA-UE was changed to 41.32 ± 11.50 from the pre-intervention score of 25.76 ± 15.26 (P < 0.001). Post-intervention, the mean score of FMA-A was increased to 26.89 ± 0.93 from 17.36 ± 1.21 (P < 0.001). The pre-assessment score of FMA-WH was 8.29 ± 0.96 and post-intervention, it was increased to 14.13 ± 0.88 (P < 0.001). The experimental group of subjects was recorded to have a reduction in the shoulder subluxation. The grade of FBP reduced to 0.39 ± 0.11 from the pre-intervention score of 1.23 ± 0.13 (P < 0.001).

Conclusion:
SBMT was concluded to be superior and highly significant than the conventional intervention for enhancing upper limb motor recovery among post-stroke hemiparetic subjects. Further, the grade of shoulder subluxation was also found to be significantly reduced among the SBMT group participants in comparison to the control subjects.