bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical feasibility of duodenum-preserving pancreatic head resection for neuroendocrine tumors of the pancreatic head as intermediate procedure between enucleation and pancreaticoduodenectomy
Authors: Shimura Masahiro , Kato Hiroyuki , Asano Yukio , Ito Masahiro , Arakawa Satoshi , Koike Daisuke , Ochi Takayuki , Yasuoka Hironobu , Kawai Toki , Higashiguchi Takahiko , Tani Hiroki , Kunimura Yoshiki , Kondo Yuka , Nagata Hidetoshi , Sato Harunobu , Kamio Kenshiro , Horiguchi Akihiko 
Published: January 2023

Abstract
Background
This study aimed to demonstrate the clinical application of duodenum-preserving pancreatic head resection (DPPHR) as a surgical treatment for pancreatic neuroendocrine tumors (PNETs) in terms of both curability and maintenance of postoperative quality of life.
Methods
A total of seven patients diagnosed with PNET underwent DPPHR between January 2011 and December 2021 at our institution. We investigated the clinical relevance of DPPHR based on clinicopathological findings in patients who underwent the surgery.
Results
Median operative time was 492 min, and blood loss was 302 g. In terms of postoperative complications according to Clavien-Dindo classification, postoperative intraabdominal bleeding was seen in one patient. Pathological examination revealed WHO classification of G1 in 6 cases and G2 in one case. Microvascular invasion (MVI) was observed in two cases (29%), however, no lymph node metastasis or recurrence occurred during the follow-up period. A daughter lesion was observed near the primary tumor in one case. All patients achieved curative resection, and none of the cases showed positive margins.
Conclusions
DPPHR allows anatomical resection of the pancreatic head in patients with PNETs, and also facilitates detailed pathological evaluation of the resected specimen. Therefore, this surgical procedure is an acceptable alternative to pancreaticoduodenectomy or enucleation for patients with PNETs.
Nonlinear topology optimization design and gripping tests of
a novel origami chomper-based flexible gripper
Authors: Liu Jie , Chen Zijie , Wen Guilin , He Junfeng , Wang Hongxin , Xue Liang , Long Kai , Xie Yi Min 
Published: January 2023

Abstract
Although the flexible origami gripper can handle a wide range of objects, there is a need for significant further improvement in its gripping performance. This study develops a novel nonlinear topology optimization (NTO) method to enhance the gripping performance of an origami chomper-based flexible gripper. The proposed NTO method incorporates the additive hyperelasticity technique and multi-resolution design (MRD) strategy with the advantages of being computationally efficient, having excellent convergence, and enabling refined design. The effectiveness of the proposed NTO method is validated by two compliant mechanism benchmark examples, i.e., the displacement inverter and gripper mechanisms. We apply the NTO method to the origami chomper-based flexible gripper to redistribute the material at the creases to obtain the optimized origami chomper-based flexible gripper. Several optimized origami chomper-based flexible gripper prototypes are fabricated by using laser cutter, followed by a series of experiments to test the gripping performances, including gripping range capability under an identical input load, maximum gripping ratio, gripping adaptability, and achieving richer gripping characteristics by size scaling. Results demonstrate that the optimized origami chomper-based flexible gripper can handle a wide range of objects irregularities in textures and uneven shapes;and the gripping range capability can be significantly enhanced by the NTO method. We also show that the optimized origami chomper-based flexible gripper can enable effective gripping of objects across scales from millimeters to centimeters to decimeters through size scaling.
Climate Labels and the restaurant industry: A qualitative study
Authors: Gay Anne-Sophie , Lane Hakan 
Published: January 2023

Abstract
Purpose
As the food industry accounts for more than one-third of global anthropogenic greenhouse gas emissions, it is one of the single largest contributors to climate change. Strategies for reductions of CO2e (equivalent) emissions must be put in place to regulate the impact the food systems have on the climate Environmental communication using climate labels sharing information on carbon footprints can help reduce GHGs emissions from restaurant purchases on a systemic scale.
Aim
The aim is to gain insights and study how a carbon label influences the concept of what is a climate-friendly restaurant and its capacity to bridge the gap between knowledge, awareness, and action. What are the motivations for restaurants’ employees to adopt climate-friendly behaviour? How does the use of the label influence the decision for restaurants to track their carbon footprint overtime, communicate the carbon footprint of dishes, and adapt menus to be more climate friendly?
Method
The data was collected with semi-structured interviews made with video communication with three restaurant chains all using the labels.
Analysis
The data collected via the interviews were examined using an inductive thematic analysis to identify key themes. The transcending transmission approach to communication was used to gain insights into both instrumental and constitutive communication dynamics. A s the theoretical framework, ‘symbolic interactionism’ helps untangle constitutive aspects of environmental communication surrounding climate labels to analyse the process of conceptualisation through usage, co-creation and interpretation.
Results and discussion
The analysis brought forward three main themes; First, the interactions between the scientific data accessible in the tool and the restaurants. Second, the diverse implications of sustainability marketing for motivating climate actions and what they look like. And finally, climate actions and how they are being apprehended and implemented by the restaurants. The promise of climate labels was discussed by both elaborating on sociocultural dynamics, sustainability marketing and activism forces and impulses influencing the motivations for restaurants. We then discussed the capacity to transcend information into action through collaboration, and inclusiveness to avoid greenwashing.
Conclusions
Restaurants have both a commercial interest to implement climate labels in their business as well as an intrinsic desire to be a company that take actions for the planet because of the restaurants’ employees’ convictions. However, restaurants find themselves in a tricky situation where they can be damned if they take ‘wrong’ actions that can be considered greenwashing, and damned if they do nothing. the software enables restaurants to legitimise their actions and communicate them to make them resilient and evolving.
Green fruit visitor insects of Annona senegalensis Pers. (Magnoliales: Annonaceae) and their potential role in the plant fruiting
Authors: DAO Zezouma Anselme , ROMBA Rahim , PEÑALVER-CRUZ Ainara , SATOUR Pascale , JALOUX Bruno , OUIEDRAOGO Amadé , GNANKINE Olivier 
Published: January 2023

Abstract

Annona senegalensisPers. (Annonaceae) is a wild shrub used multipurposely in food and traditional medicine by local people in African tropical countries. During its fruiting period, especially at the green fruit stage, this plant harbors an important community of insects such as the planthopperHilda undata(Tettigometridae) and various ant species (Formicidae). This study aimed at understanding the interactions between ants,Hilda undataand the plantAnnona senegalensis. Green fruit insect visitors ofA. senegalensiswere collected randomly from 30 green fruits of 30 plants per site, at four sites across the Sudanian and Sudano-Sahelian climatic zones of Burkina Faso during the green fruit stage of the plant, from June to July. The behavior of green fruit visiting insects was observed in the field. In addition, ants andHilda undatawere collected and their whole body sugars were analyzed. Ants were the most recorded visiting insect group, representing up to 95% of the insects observed on the fruit. The orders of insects recorded were Coleoptera, Diptera, Hemiptera, Hymenoptera and Lepidoptera and the most frequently encountered species wereTrichomyrmex abyssinicus,Crematogastersp (Formicidae),Messor galla(Formicidae),Brachyponera sennaarensis(Formicidae) andH. undata. Behavioural observations showed that ants consume extrafloral nectar from green fruits and honeydew fromH. undata. The ants would protect the green fruits from their pests andH.undatafrom its natural enemies. This study is the first report highlighting mutualistic interactions betweenA. senegalensis, ants andH. undata.
Proteomic analysis of sialoliths from calcified, lipid and mixed groups as a source of potential biomarkers of deposit formation in the salivary glands
Authors: Musiał Natalia , Bogucka Aleksandra , Tretiakow Dmitry , Skorek Andrzej , Ryl Jacek , Czaplewska Paulina 
Published: January 2023

Abstract

Salivary stones, also known as sialoliths, are formed in a pathological situation in the salivary glands. So far, neither the mechanism of their formation nor the factors predisposing to their formation are known despite several hypotheses. While they do not directly threaten human life, they significantly deteriorate the patient's quality of life. Although this is not a typical research material, attempts are made to apply various analytical tools to characterise sialoliths and search for the biomarkers in their proteomes. In this work, we used mass spectrometry and SWATH-MS qualitative and quantitative analysis to investigate the composition and select proteins that may contribute to solid deposits in the salivary glands. Twenty sialoliths, previously characterized spectroscopically and divided into the following groups: calcified (CAL), lipid (LIP) and mixed (MIX), were used for the study. Proteins unique for each of the groups were found, including: for the CAL group among them, e.g. proteins from the S100 group (S100 A8/A12 and P), mucin 7 (MUC7), keratins (KRT1/2/4/5/13), elastase (ELANE) or stomatin (STOM); proteins for the LIP group - transthyretin (TTR), lactotransferrin (LTF), matrix Gla protein (MPG), submandibular gland androgen-regulated protein 3 (SMR3A); mixed stones had the fewest unique proteins. Bacterial proteins present in sialoliths have also been identified. The analysis of the results indicates the possible role of bacterial infections, disturbances in calcium metabolism and neutrophil extracellular traps (NETs) in the formation of sialoliths.
Care Quality from the Perspective of Human Rights as Perceived by Mental Health Professionals in Gran Canaria: a qualitative study.
Authors: Arévalo Cira Febles , Domínguez Jose Juan Martín , Montesdeoca Rafael García , Quevedo Rocío Hidalgo , Vázquez Francisco Navarro 
Published: January 2023

Abstract
Background: Mental health facilities and other medium and long-stay hospital wards have been associated with poor quality care and human rights violations. This idea has led us to do this qualitative research.
Objective: To explore how the health care professionals working at the medium and long-term hospitalisation services of the Network of Mental Health Facilities of Gran Canaria (Red de Salud Mental de Gran Canaria) perceive, from the human rights standpoint, the quality of the care that they provide, identifying the different attitudes, values and knowledge of the professionals involved.
Methods: An exploratory, descriptive qualitative research conducted through 17 semi-structured interviews and 4 focal groups. The areas discussed are based on the QualityRightsassessment toolkit. After collecting the data, the contents of the narratives were analysed.
Results: The respondents identified the lack of health care resources and social support, the predominant paternalism in the care provided and the prevailing biomedical approach as the main causes that erode the respect for human rights. In this context, an improvement in the professionals' training seems to be one of the potential solutions to address this issue.
Conclusions: Analysing and doing research about the provision of human-rights-based care to individuals with mental health conditions in the institutional setting leads professionals to think about the care they provide. If this piece of research has managed to change attitudes, even minimally, it was worth doing it.
Scalable Facial Authentication System for a Distributed Environment Using Feature Dimensionality Reduction
Authors: MFITUMUKIZA Joseph , KIM Tae Yong 
Published: January 2023

Abstract

The user authentication of personal identification using a face image relies on biometric features known as facial features. A facial authentication system is critical for access control and intelligent human computer interaction. However, the challenges include numerous training data requirement and high processing power due to computational complexity. Therefore, this paper proposes a scalable face authentication system for a distributed environment using feature dimensionality reduction (FDR). This study contributes to a constructive comparison of classical and state-of-the-art feature extraction techniques to develop of distributed environment-based scalability using FDR. The scalability for the distributed environment, is proven to extend the user access capacity by overcoming the multiple training data requirements while the new end-user access is authenticated in system. The accuracy and processing time were chosen as the performance metrics evaluating the proposed method. The features extracted using deep convolutional neural network (DCNN) as the state-of-the-art algorithm reveal remarkable performance using FDR with the principal component analysis algorithm and support vector machine for classification, compared to classical feature vector extractor algorithms such as the Gabor filter, histogram of oriented gradient and local binary pattern. The experimental results on the FERET dataset, demonstrate that the feature extracted by the DCNN is a more robust representation of scalability with up to 50% for FDR using half the processing time compared to the facial feature extracted using classical methods.
Elastic resistance training has positive influence on the functional capacity and appetite hormone in overweight men
Authors: Valadbeigi Armin , Azizbeigi Kamal 
Published: January 2023

Abstract
Purpose Exercise training may influence on appetite hormones and energy homeostasis.
Aims The purpose of the current study was to investigate the effect of resistance training with elastic band (ERT) on ghrelin (GHRL) and Obestatin (OBST) hormone concentration changes in overweight men.
Methods 20 male overweight (25<BMI≤29.5 kg/m2) voluntary participated in the current study and randomly assigned in the resistance training with elastic bands (ERT; n=10), and control (Con; n=10). Elastic resistance training was done three sessions in week in nonconsecutive for eight weeks. Blood sample was gathered before ERT and was repeated 48 hour interval with the last session of exercise training. GHRL and OBST were assessed in the plasma. Also, functional capacity (Push UP: PU; Squat: SQ) was assessed, and body fat percentage (BF %) were estimated.
Results We found that there was a significant difference in GHRL in the ERT than control [time× group (p=0.045; F=4.38)], however, there was no significant difference in OBST (p˃0.05). It was also seen that the interactive effect of time in the ERT (time× group) was significant for PU and SQ [(p=0.004; F=8.02), and SQ (p=0.011; F=8.1], respectively. Also, a decrease was seen in BF% in the ERT than control (p≤0.001).
Conclusion Finally, it can be concluded elastic resistance training with elastic bands have an positive impact on the functional capacity and appetite hormones and should be taken into consideration in the design of weight control protocols.
A trispecific T cell engager CD19xCD3xCD28 induces potent tumor-directed T cell activation and antitumor activity by simultaneously engagement of TCR and a co-stimulatory receptor CD28
Authors: Chen Li , Qian Wenjing , Pan Fangfang , Li Debin , Yu Weiwei , Tong Li , Yang Yingying , Xu Qiming , Ding Jianfeng , Dai Ruixue , Xian weiwei , Zhu Xufeng , Ren Pu , Zhu Huaxing 
Published: January 2023

Abstract
T-cells, being the major player in adaptive immune system mediating cellular immunity, have become a central focus for engaging the immune system in fighting against cancer. Their activation is initiated by recognition of antigen/major histocompatibility complexes by the T-cell receptor (TCR) and enhanced by engagement of co-stimulatory receptor. In recent years, various immunotherapies deploying T-cell immunity have made immense progress, including chimeric antigen receptor (CAR)-T therapy, checkpoint blockage, and CD3-based bispecific antibodies. Here we report the development of a novel trispecific antibody to CD19, CD3, and CD28, with an emphasis on the co-engagement of both CD3/TCR complex and CD28 co-stimulatory receptor for sustained T cell activation. Compared with the BiTE-CD19xCD3 lacking the co-stimulatory domain, the trispecific antibody augmented T cell proliferation and differentiation into memory T cells. It induced faster tumor cell lysis than the bispecific antibody, preferably through direct tumor lysis by CD8 T cells. RNAseq analysis revealed that the trispecific antibody modulates TCR complex-derived signal at multiple aspects, including amplification of transcriptional factors, promoting production of cytokines, positive regulation of cell cycle, and upregulation of anti-apoptotic factors to influence survival of T-cells. Markedly increased tumor inhibition effects and prolonged survival were observed in vivo in humanized mouse model. By extra engagement of a co-stimulatory receptor to prolong the survival of activated T cells, our study has proposed another possibility to extend the pharmacology effect of tandem single-chain variable fragments (scFv)-based antibody, which is worthy of further exploration in clinical trial settings.
Diagnostic challenge: Primary leptomeningeal melanoma with melanomatosis, illustrative case report
Authors: ElOuazzani Hafsa , Oudghiri Mohammed Yassaad , Abbas Salma , Regragui Asmaa , Elouahabi Abdessamad , Cherradi Nadia 
Published: January 2023

Abstract
Background: Primary leptomeningeal melanoma is an extremely rare type of intracranial melanoma. It cannot be reliably distinguished from metastatic melanoma on neuroimaging and histopathological characteristics alone; its diagnosis is established only after exclusion of secondary metastatic disease from a cutaneous, mucosal or retinal primary [1, 2]. Prognosis is poor, partly due to its high rate of misdiagnosis.
Case presentation: We report a case of a Primary Meningeal Melanoma of the skull base with Melanomatosis, in 31 years old man, mimicking clinical and radiological features of meningioma and whose delayed treatment has worsened the prognosis.
Conclusion: Through this case, we highlight the diagnostic difficulties and we discuss the histopathological differential diagnoses especially with other pigmented lesions of Central nervous system (CNS).
Phase Transition in a Phonon Gas With Pair Correlations
Authors: Poluektov Yuri 
Published: January 2023

Abstract
The phase transition to the state of a phonon gas with pairwise correlations of interacting phonons with opposite momenta is studied. A method for describing such phonon systems within the framework of the self-consistent field model is developed and their thermodynamic characteristics are calculated. It is shown that a phonon gas with pair correlations can exist in a state of unstable thermodynamic equilibrium. The possibility of experimental observation of a solid in such a phase is discussed.
PACS numbers: 05.30.Jp, 05.70.Fh, 63.20.-e, 63.20.K, 63.20.Ry, 65.40.-b, 67.80.-s
A metagenomic survey on Solanum tuberosum virome revealed environmental contamination of a laboratory-developed strain of SARS-CoV-2
Authors: Hassanpour Mina , Mohebbi Alireza 
Published: January 2023

AbstractMetagenomics is a promising approach to discovering viral sequences in environmental samples. We used recently published RNA-Seq data ofSolanum tuberosum(S. tuberosum) from China for a metavirome study. Several environmentally related non-intact viruses read from forest animals, moths, bacteria, and amoeba were detected. Further investigation resulted in non-indigenous sequences of SARS-CoV-2 genomes of lineage B with novel substitutions. Three substitutions, including A22D and A36V in the envelope protein and Q498H in the spike glycoprotein that were recently reported from a laboratory strain virus with enhanced virulence, were detected in all samples. Further substitutions at ORF1ab were also uncovered. These were L1457V, D4553N, W6538S, I1525T, D1585Y, D6928G, N3414K, T3432S. Two unexpected frameshifts, ORF1a:2338–4401 and ORF1a:3681–4401, were noticed within the ORF1ab. The genomic evidence and geographical evidence of lab leaks are also provided. The findings of the presented study highlight the threats of the emerged potentially severe genotypes bearing substitutions that are not yet clinically reported. More studies are warranted to uncover the role of the novel substitutions in the severity of SARS-coV-2
A Case of Pulmonary Tuberculosis Followed by Penicilliosis Marneffei without HIV Infection
Authors: Yang Wei , Xu Xiaofeng 
Published: January 2023

Abstract
Background: Penicilliosis marneffei（P. Marneffei） is an important opportunistic pathogen found in in human immunodeficiency virus（HIV）-positive individuals. But there are few reports that tuberculosis （TB） patients are followed by P. Marneffeiwithout HIV Infection.
Case presentation:A female patient, aged 45, admitted to a local hospital in 2008 due to fever and cough. The patient received transbronchial needle aspiration under bronchoscopy, and the smear indicated positive for acid-fast bacilli. Therefore, the patient began to receive 2HRZE/7HR regimen on May 23, 2009 untill to February 2010. The patient returned to normal.On April 25,2014, the patient had fever again and received HRZEMfx regimen. Two weeks late, the patient still had fever. He received lymph node biopsy and was confirmed as P. Marneffeiby pathological examination, tissue culture and transmission electron microscopy analysis. Multiple HIV tests were all negative.Patient’s fever subsided after intravenous infusion of voriconazole for 2 weeks, and the patient recovered after oral administration of the same dose of voriconazole tablets for 6 months.
Conclusions: After the regular anti-TB treatment and stability, TB patients again have the clinical manifestations such as fever, swollen lymph nodes, etc. We cannot simply consider TB recurrence or resistance. Clinicians need to consider the possibility of infection with other pathogens.