bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uptake of pediatric patient-reported outcome and experience measures and challenges associated with their implementation in Alberta: a mixed-methods study
Authors: Bele Sumedh , Rabi Sarah , Zhang Muning , Ahmed Sadia , Paolucci Elizabeth Oddone , Johnson David W. , Quan Hude , Santana Maria J. 
Published: July 2023

Abstract
Background
Implementing Patient-reported Outcome Measures (PROMs) and Patient-reported Experience Measures (PREMs) is an effective way to deliver patient- and family-centered care (PFCC). Although Alberta Health Services (AHS) is Canada's largest and fully integrated health system, PROMs and PREMs are yet to be routinely integrated into the pediatric healthcare system. This study addresses this gap by investigating the current uptake, barriers, and enablers for integrating PROMs and PREMs in Alberta's pediatric healthcare system.

Methods
Pediatric clinicians and academic researchers with experience using PROMs and PREMs were invited to complete a quantitative survey. Additionally, key stakeholders were qualitatively interviewed to understand current challenges in implementing pediatric PROMs and PREMs within AHS. Quantitative data gathered from 22 participants were descriptively analyzed, and qualitative data from 14 participants were thematically analyzed.

Results
Participants identified 33 PROMs and 6 PREMs showing diversity in the types of pediatric PROMs and PREMs currently being used in Alberta and their mode of administration. The qualitatively identified challenges were associated with patients, family caregivers, and clinicians. The absence of system-level support, such as integration within electronic medical records, is considered a significant system-level challenge.

Conclusions
The significant variation in the types of PROMs and PREMs used, the rationale for their use, and their mode of administration demonstrate the diverse and sporadic use of these measures in Alberta. These findings highlight the need for province-wide uniform implementation of pediatric PROMs and PREMs in Alberta. Our results could benefit healthcare organizations in developing evidence-based PROM and PREM implementation strategies in pediatrics.
Predictors of quality of life and mental health in breast cancer survivors in Northern Iran
Authors: Zolfaghary Fatemeh , MashaghiTabari Reza , Dezhman Mobina , Bijani Ali , Kheirkha Farzan , Adib-Rad Hajar 
Published: July 2023

Abstract
Background and purpose
The global incidence of breast cancer is the highest among all cancers and is the primary reason for cancer-related fatalities. Our study aimed to assess the predictors of quality of life (QOL) and mental health in breast cancer survivors in Northern Iran.

Methods
This cross-sectional study was done on 96 female breast cancer survivors between the ages of 20 and 65 and was based on convenience samples. We gathered information through demographic and fertility data, a QOL survey, and the Hospital Anxiety and Depression Scale (HADS). A significance level of P < 0.05 was set for the analysis.

Results
In this study, results showed that 11.5% of women had the optimal quality of life, 31.3% favorable quality of life, and 57.3% undesirable quality of life. The average HADS score was 20.14 ± 3.07, with anxiety scores of 10.21 ± 2.31 and depression scores of 9.93 ± 1.64. On multiple linear regression, marital relationship and the number of children were predictors of quality of life (β=-17.624, p = 0.023 and β=-7.427, p = 0.016, respectively), as well as the husband’s education and having no history of other cancers in the woman, were the most important predictors of HADS (β = 0.763, p = 0.039 and β=-0.528, p = 0.016, respectively).

Conclusion
It is crucial to provide exceptional care to breast cancer patients during treatment and post-recovery. Emotional and psychological support is a fundamental requirement for their well-being.
Can the ketogenic diet improve our dreams? Effect of very low-calorie ketogenic diet (VLCKD) on sleep quality
Authors: Barrea Luigi , Verde Ludovica , Di Lorenzo Cherubino , Savastano Silvia , Colao Annamaria , Muscogiuri Giovanna 
Published: July 2023

Abstract
Background
Obesity is a condition that is often associated with sleep disorders, including reduced sleep quality (SQ). Very low calorie ketogenic diet (VLCKD) has proven to be effective in the management of obesity and associated metabolic disorders. However, little is still known about the effects of this promising nutritional protocol on SQ. Thus, the purpose of this study was to investigate the short-term effect of VLCKD on SQ in women with overweight/obesity and if any changes, to identify the predictive factor that through VLCKD modified SQ.

Methods
Were consecutively enrolled a total of 324 subjects, who met the inclusion criteria and accepted to adhere to VLCKD. Assessment of nutritional status, including anthropometric measurements (height, weight, and waist circumference), bioelectrical impedance analysis (phase-sensitive system, 50 kHz BIA 101 RJL, Akern Bioresearch, Florence, Italy Akern), high sensitivity C reactive protein levels (hs-CRP), and SQ were carried out at baseline and after 31 days of active stage of VLCKD. SQ was evaluated using the validated questionnaire Pittsburgh Sleep Quality Index (PSQI).

Results
In addition to the expected general improvement of anthropometric parameters and body composition, VLCKD improved significantly SQ, as demonstrated by the improvement of all parameters included in the PSQI questionnaire (p < 0.001). Both at baseline and after 31 days of active stage of VLCKD, the PSQI score was significantly associated with BMI, waist circumference, fat mass, fat free mass (p < 0.001 for all) and hs-CRP (p = 0.023). PhA was negatively associated with PSQI score only at baseline (p < 0.001). ∆% PSQI positively correlated with ∆% BMI, ∆% fat mass, ∆% hs-CRP (p < 0.001 for all) and negatively correlated with ∆% fat free mass (p < 0.001), and ∆% PhA (p = 0.031). In the multiple regression analysis ∆% fat mass represented the only predictor of changes in SQ after VLCKD. Finally, in the ROC analysis, a threshold value of ∆% fat mass > − 8.4% predicted improvement in SQ (p < 0.001).

Conclusion
In conclusion, VLCKD determines an improvement of SQ in women with overweight and obesity, that was mostly mediated by the reduction of fat mass related to this nutritional protocol.

Graphical Abstract
DNMT3A mutation promotes leukemia development through NAM-NAD metabolic reprogramming
Authors: Yang Xuejiao , Wang Xiao , Yang Ying , Li Zhiyang , Chen Yunshuo , Shang Siqi , Wang Yueying 
Published: July 2023

Abstract
Background
DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia (AML) with Arg882His (R882H) as the hotspot mutation. It has been reported that DNMT3A mutation plays a key role in leukemogenesis through hypomethylation of some target genes associated with cell growth and differentiation. In this study, we investigated the function of DNMT3A R882H in the malignant progression of AML by regulating metabolic reprogramming.

Methods
Ultra-High Performance Liquid Chromatography–High Resolution Tandem Mass Spectrometry (UHPLC-HRMS/MS) was used to detect metabolites in the serum of mice harboring Dnmt3a R878H mutation and the wild-type Dnmt3a. Methylated DNA Immunoprecipitation Sequencing (MeDIP-seq) and RNA sequencing (RNA-seq) were used to analyze the levels of DNA methylation and mRNA expression of genes in mouse Gr1+ bone marrow cells respectively. The TCGA and GO databases were used to analyze the differential genes between human samples carrying the DNMT3A R882 mutation and the wild-type DNMT3A. Co-immunoprecipitation and immunoblotting were used to illustrate the binding levels of Cyclins-CDKs and CDK inhibitors including CDKN1A and CDKN1B. Flow cytometry was used to analyze the cell differentiation, division, apoptosis and cell cycle. The effect of NAMPT inhibition on leukemia was evaluated by using in vivo fluorescence imaging in NOG mouse model bearing OCI-AML3 cells.

Results
DNMT3A mutation caused high expression of nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in the nicotinamide adenine dinucleotide (NAD) salvage synthetic pathway, through DNA hypomethylation, and finally led to abnormal nicotinamide (NAM) metabolism and NAD synthesis. The NAM-NAD metabolic abnormalities caused accelerated cell cycle progression. Inhibition of NAMPT can reduce the binding degree between Cyclins-CDKs, and increase the binding interaction of the CDK inhibitors with Cyclins-CDKs complexes. Moreover, cells with high expression of NAMPT were more sensitive to the NAMPT inhibitor FK866 with a lower IC50. The inhibition of NAMPT can remarkably extend the survival time of tumor-bearing mice and reduce the infiltration of tumor cells.

Conclusions
Taken together, our data showed that DNMT3A mutation caused NAMPT overexpression to induce the reprogramming of NAM-NAD metabolism and contribute to abnormal proliferation, which provided a potential direction for targeted therapy at the metabolic level in AML with DNMT3A mutation.
Sex Steroids Regulate Liver Fat Content and Body Fat Distribution in Both Men and Women: A Study in Transgender Persons
Authors: Tebbens Marieke , Schutte Moya , Troelstra Marian A , Bruinstroop Eveline , de Mutsert Renée , Nederveen Aart J , den Heijer Martin , Bisschop Peter H 
Published: July 2023

Abstract

Context
Liver fat content and visceral fat volume are associated with insulin resistance and cardiovascular disease and are higher in men than in women.

Objective
To determine the effect of estradiol and testosterone treatment on liver fat and visceral fat in transgender persons.

Design
Open-label intervention study (SHAMVA) with a 1-year follow-up.

Setting
Gender clinic in a hospital.

Patients
8 trans women and 18 trans men receiving hormone treatment.

Interventions
Trans women received an antiandrogen and after 6 weeks estradiol was added. Trans men were randomized to receive triptorelin, testosterone, and anastrozole for 12 weeks or triptorelin and testosterone for 12 weeks, followed by only testosterone until week 52.

Main outcome measures
Liver fat content, visceral and abdominal subcutaneous fat volume, measured by magnetic resonance spectrometry or imaging at baseline, 6, 8, 18, and 58 weeks in transwomen or at baseline; at 6 and 12 weeks in trans men with anastrozole; and at 52 weeks in trans men without anastrozole.

Results
In trans women, liver fat content decreased by 1.55% (−2.99 to −0.12) after 58 weeks, compared to week 6. Visceral fat did not change. In trans men with anastrozole, the liver fat content and visceral fat volume did not change. In trans men without anastrozole, after 52 weeks, liver fat content increased by 0.83% (0.14 to 1.52) and visceral fat volume increased by 34% (16 to 51).

Conclusions
Sex hormones regulate liver fat content and visceral fat in men and women.
Predictors of Early Versus Late Recurrence in Invasive Lobular Carcinoma of the Breast: Impact of Local and Systemic Therapy
Authors: Rothschild Harriet T. , Clelland Elle N. , Mujir Firdows , Record Helena , Wong Jasmine , Esserman Laura J. , Alvarado Michael , Ewing Cheryl , Mukhtar Rita A. 
Published: July 2023

Abstract
Background
Invasive lobular carcinoma (ILC) of the breast is known for high risk of late recurrence, yet some patients still recur within 5 years of diagnosis. Determining factors associated with early/late recurrence could help tailor treatment and surveillance strategies.

Methods
Using an institutional database, we evaluated patients with ILC and ≥ 5 years of follow-up or recurrence within 5 years. We used multivariate logistic regression and the Kaplan-Meier method to evaluate which clinicopathologic features and treatment strategies were associated with recurrence < 5 years since diagnosis versus recurrence ≥ 5 years since diagnosis. Additionally, we explored the association between Clinical Treatment Score 5 (CTS5) with early versus late recurrence.

Results
Among 513 cases of stage I–III ILC, there were 75 early and 54 late recurrences during a median follow-up period of 9.4 years. Early recurrence was associated with larger tumors (mean 4.2 cm vs. 2.9 cm, p < 0.0001), higher incidence of > 3 positive nodes (32.4% vs. 9.11%, p > 0.0001), and more aggressive tumor biology (low/negative progesterone receptor expression, higher grade, and higher Ki67). Late recurrence was associated with younger age (mean 55.6 vs. 59.2 years, p = 0.037) and elevated body mass index (BMI > 25 kg/m2 in 60.1.0% vs. 45.4%, p = 0.021). Omission of adjuvant endocrine therapy or radiotherapy after lumpectomy conferred increased risk of early rather than late recurrence.

Conclusion
Factors related to tumor aggressiveness and treatment were associated with early recurrence, whereas patient related factors were related to late recurrence. These data may help guide treatment strategies and surveillance approaches for patients with ILC.
Bayesian and non-Bayesian estimation of dynamic cumulative residual Tsallis entropy for moment exponential distribution under progressive censored type II
Authors: Alyami Salem A. , Hassan Amal S. , Elbatal Ibrahim , Elgarhy Mohammed , El-Saeed Ahmed R. 
Published: July 2023

Abstract
The dynamic cumulative residual (DCR) entropy is a helpful randomness metric that may be used in survival analysis. A challenging issue in statistics and machine learning is the estimation of entropy measures. This article uses progressive censored type II (PCT-II) samples to estimate the DCR Tsallis entropy (DCRTE) for the moment exponential distribution. The non-Bayesian and Bayesian approaches are the recommended estimating strategies. We obtain the DCRTE Bayesian estimator using the gamma and uniform priors via symmetric and asymmetric (linear exponential and general entropy) loss functions (LoFs). The Metropolis–Hastings algorithm is employed to generate Markov chain Monte Carlo samples from the posterior distribution. The accuracy of different estimates for various sample sizes, is implemented via Monte Carlo simulations. Generally, we note based on the simulation study that, in the majority of cases, the DCRTE Bayesian estimates under general entropy followed by linear exponential LoFs are preferable to the others. The accuracy measure of DCRTE Bayesian estimates using a gamma prior has smaller values than the others using a uniform prior. As sample sizes grow, the Bayesian estimates of the DCRTE are closer to the true value. Finally, analysis of the leukemia data confirmed the proposed estimators.
The ‘Lying Down Menology’: Instructions for a Year of Auspicious Dreams
Authors: Hätinen Aino 
Published: July 2023

Abstract
The ‘Lying Down Menology’ is a previously unedited text belonging to the corpus of Mesopotamian hemerological and calendrical texts. It contains a set of ritual instructions about hygiene, clothing, food and drink, sexual relations, and sleeping for each of the twelve months of the year; the goal is to obtain an auspicious dream. This menology was one of the texts used to compile the royal hemerology ‘Inbu bēl arḫi’, and its transmission can be followed to late period Babylonia where it is associated with the micro-zodiac.
MEMBUDAYAKAN CARA MEMBUAT KEPUTUSAN BERTERASKAN MAQASID SYARIAH DALAM PENGURUSAN ORGANISASI ISLAM
Authors: T.M Tuan Sidek , Ismail  
Published: July 2023

Decision making is an important matter in the management of the organization including the management of Islamic organizations. The decision-making process takes place at various levels of management. A good decision will make the affairs of an institution run smoothly, the benefits are felt by various parties, reduce conflict and produce more effective management. Thus, a conceptual article entitled Cultivating Method of Decision-making Based on Maqasid Syariah in Islamic Organizational Management was written to suggest efforts to cultivate a decision making based on contemplating the concept and application of maqasid syariah. This article explains the concept and application of maqasid syariah and its suitability in helping parties involved in Islamic management to cultivate a way of making decisions based on maqasid syariah. Hopefully this article can help promote the method of thinking and decision making based on one of the treasures of Islamic intellectuals as well as helping the management of Islamic organizations to improve and remain in line with the changing times.

Membuat keputusan adalah suatu perkara yang penting dalam pengurusan organisasi termasuklah dalam pengurusan organisasi Islam. Proses membuat keputusan berlaku pada pelbagai peringkat pengurusan. Keputusan yang baik akan menjadikan urusan sesebuah institusi berjalan dengan lancar, manfaatnya dirasai oleh pelbagai pihak, mengurangkan konflik serta menghasilkan pengurusan yang lebih efektif. Sehubungan dengan itu, tulisan berbentuk konsep yang bertajuk Membudaya Cara Membuat Keputusan Berteraskan Maqasid Syariah dalam Pengurusan Organisasi Islam ditulis untuk mencadangkan usaha membudayakan cara membuat keputusan berpandukan kepada penghayatan terhadap konsep dan aplikasi maqasid syariah. Tulisan ini menjelaskan konsep dan aplikasi maqasid syariah dan kesesuiannya dalam membantu pihak yang terlibat dalam pengurusan Islam untuk membudayakan cara membuat keputusan berasaskan maqasid syariah. Semoga tulisan ini dapat membantu mempromosi kaedah berfikir dan membuat keputusan berpandukan salah satu khazanah intektual Islam di samping dapat membantu pengurusan organisasi Islam menjadi bertambah baik dan kekal bersesuaian dengan perubahan zaman.
State Interest and the Vicious Circle of the Police: Michel Foucault&#x27;s Model
Authors: Makarenko V.P. 
Published: July 2023

M. Foucault developed a model of the police as a political technology that sought to manage in accordance with the state interest (hereinafter GI). This model is based on the analysis of many phenomena of being and thinking. These include: temporal-spatial differences in the understanding of the term police during the XV–XVIII centuries; the connections of the police of Italy, Germany and France with the general balance of Europe; the genesis of the police in these countries to establish the national specifics of police science; the genesis of the concept of state benefit as a bureaucratic innovation and the basis of the utopia of the police state. Foucault established that for two hundred years (XV–XVI centuries), the term police was understood in three ways: as communities under the control of the authorities, specific acts of management, positive overall results of management. However, in the next two hundred years (XVII–XVIII centuries) the police began to be called a set of tools that allow controlling the relationship between social order and the growth of state forces in order to ensure a link between the state&#x27;s well-being and the happiness of all citizens. With this approach, the police qualified as a space-time synthesis of beauty, order and strength, which is guaranteed by the police as a set of “laws and regulations concerning the internal life of the State and seeking to strengthen and increase the power of this state, seeking to achieve the correct use of its forces”. The purpose of the article is to abstract the material of two Foucault lectures to systematize the real variety of aspects of the main problem indicated in the title. On this basis, the problem-heuristic potential of this fragment of M. Foucault&#x27;s political theory is reconstructed.
Professional identity development, self-efficacy and sense of coherence in Nursing Education
Authors: Vabo Grete , Haugen Tommy 
Published: July 2023

Abstract
Background.
For nursing students, it is important to learn how to think as a nurse and have a professional identity development. Nursing students are required a safe learning environment and reflection time to enhance their professional identity. The purpose of this study was firstly to examine nursing students’ professional identity development during education. Secondly it was to investigate the predictive value of self-efficacy and Sence of Coherence (SOC) on the professional identity of nursing students also during the education.
Methods.
A longitudinal study design was used to explore this development during education time. The relationship between sense of coherence, self-efficacy and professional identity were explored. Data were collected through self-reported questionnaires, three times. Statistical software jamovi 1.2.9 was used for the data analysis. Repeated measures ANOVA, and a multiple linear regression analysis were performed.
Result.
Professional identity development increased over time, and changes from Time 1–Time 3 were statistically significant. The only statistically significant predictor was students’ self-efficacy.
Conclusion.
To integrate self-efficacy when preparing the curriculum for nursing students, can lead to more competent nurses, and further on professional nurses with a higher level of professional identity.
Association between serum eicosapentaenoic acid/arachidonic acid ratio and overall survival in patients with non-small cell lung cancer treated with pembrolizumab
Authors: Tanaka Ikue , Yano Yukihiro , Mori Masahide , Manabe Satoru , Fukuo Keisuke 
Published: July 2023

Abstract
This pilot study was based on an analysis of the dietary patterns of patients with non-small cell lung cancer (NSCLC) undergoing initial pembrolizumab, an immune checkpoint inhibitor (ICI), treatment in the month prior to treatment and an analysis of serum fatty acid fractions. Their association with ICI treatment efficacy was investigated. The results of this study showed that long-term survivors (those who survived for ≥ 3 years) consumed significantly more seafood than short-term survivors (those who survived for < 3 years). Furthermore, the serum levels of eicosapentaenoic acid (EPA) and the ratio of EPA to arachidonic acid (EPA/AA) were higher in long-term survivors than those in short-term survivors. Interestingly, the group with a high serum EPA/AA ratio had significantly higher overall survival rate after ICI treatment compared with the group with a low serum EPA/AA ratio. In conclusion, the serum EPA/AA ratio may be a useful biomarker for determining the efficacy of ICI treatment, and supplements that increase the serum EPA/AA ratio could serve as new nutritional treatments for enhancing the efficacy of ICI treatment. However, further large-scale case and intervention studies are required.
Analysis of the weighted conical and v-line Radon transform
Authors: Duy Nguyen N. 
Published: July 2023

Abstract
In this article, we investigate the weighted conical Radon transform, a novel class of Radon transforms that takes into account the attenuation effect by integrating a function over circular cones. This transform has significant applications in nuclear tomography imaging, the nuclear industry, and homeland security. We propose new inversion formulas for the weighted conical Radon transform, which an explicit formula and a formula based on convolution frames. Furthermore, we provide numerical simulations designed for 2D situation.