bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population history modulates the fitness effects of Copy Number Variation in the Roma
Authors: Antinucci Marco , Comas David , Calafell Francesc 
Published: June 2023

AbstractWe provide the first whole genome Copy Number Variant (CNV) study addressing Roma, along with reference populations from South Asia, the Middle East and Europe. Using CNV calling software for short-read sequence data, we identified 3171 deletions and 489 duplications. Taking into account the known population history of the Roma, as inferred from whole genome nucleotide variation, we could discern how this history has shaped CNV variation. As expected, patterns of deletion variation, but not duplication, in the Roma followed those obtained from single nucleotide polymorphisms (SNPs). Reduced effective population size resulting in slightly relaxed natural selection may explain our observation of an increase in intronic (but not exonic) deletions within Loss of Function (LoF)-intolerant genes. Over-representation analysis for LoF-intolerant gene sets hosting intronic deletions highlights a substantial accumulation of shared biological processes in Roma, intriguingly related to signaling, nervous system and development features, which may be related to the known profile of private disease in the population. Finally, we show the link between deletions and known trait-related SNPs reported in the genome-wide association study (GWAS) catalog, which exhibited even frequency distributions among the studied populations. This suggests that, in general human populations, the strong association between deletions and SNPs associated to biomedical conditions and traits could be widespread across continental populations, reflecting a common background of potentially disease/trait-related CNVs.
Proton pump inhibitor use and risk of pneumonia: a self-controlled case series study
Authors: Maret-Ouda John , Panula Joni , Santoni Giola , Xie Shaohua , Lagergren Jesper 
Published: June 2023

Abstract
Background
Recent research indicates that use of proton pump inhibitors (PPIs) is associated with pneumonia, but existing evidence is inconclusive because of methodological issues. This study aimed to answer whether PPI-use increases risk of pneumonia while taking the methodological concerns of previous research into account.

Methods
This population-based and nationwide Swedish study conducted in 2005–2019 used a self-controlled case series design. Data came from national registries for medications, diagnoses, and mortality. Conditional fixed-effect Poisson regression provided incidence rate ratios (IRR) with 95% confidence intervals (CI) for pneumonia comparing PPI-exposed periods with unexposed periods in the same individuals, thus controlling for confounding. Analyses were stratified by PPI-treatment duration, sex, age, and smoking-related diseases. Use of histamine type-2 receptor antagonists (used for the same indications as PPIs) and risk of pneumonia was analysed for assessing the validity and specificity of the results for PPI-therapy and pneumonia.

Results
Among 519,152 patients with at least one pneumonia episode during the study period, 307,709 periods of PPI-treatment occurred. PPI-use was followed by an overall 73% increased risk of pneumonia (IRR 1.73, 95% CI 1.71–1.75). The IRRs were increased across strata of PPI-treatment duration, sex, age, and smoking-related disease status. No such strong association was found between histamine type-2 receptor antagonist use and risk of pneumonia (IRR 1.08, 95% CI 1.02–1.14).

Conclusions
PPI-use seems to be associated with an increased risk of pneumonia. This finding highlights a need for caution in using PPIs in individuals with a history of pneumonia.
The smallest worthwhile change on function from a self-management intervention for non-persistent low back pain
Authors: Fritsch Carolina Gassen , Ferreira Paulo H. , Lung Thomas , McLachlan Andrew J. , Ferreira Manuela L. 
Published: June 2023

Abstract
Purpose
To determine: (1) the smallest change in function patients would need to see following a self-management intervention for low back pain (LBP) to consider it worthwhile; (2) the association between patient-related factors and the magnitude of the smallest worthwhile change.

Methods
A cross-sectional analysis of 212 participants of the TEXT4myBACK randomised trial was conducted. At baseline, participants nominated the smallest change in function (0–30 scale) following a self-management program they would need to reach to consider it worthwhile. A multivariate regression model estimated the effects of demographic, comorbidities, lifestyle and LBP-related factors on the smallest worthwhile change estimates.

Results
On average, people with LBP need to experience an improvement of at least 9.4 points (SD: 5.7) in function to consider a self-management intervention worthwhile. Only baseline function severity was significantly associated with the smallest worthwhile estimate (−0.60; 95%CI  − 0.76,  − 0.44).

Conclusion
On average, an improvement of 9.4 points (or 31%) in function is considered by people with LBP as the smallest change that makes self-management worthwhile. Those with lower levels of function needed to experience greater improvements.
Does Risser stage accurately predict the risk of curve progression in patients with adolescent idiopathic scoliosis treated with night-time bracing?
Authors: Heegaard Martin , Tøndevold Niklas , Dahl Benny , Andersen Thomas B. , Gehrchen Martin , Ohrt-Nissen Søren 
Published: June 2023

Abstract
Purpose
Risser stage is widely used as a marker for skeletal maturity (SM) and thereby an indirect measure for the risk of progression of adolescent idiopathic scoliosis (AIS). The Scoliosis Research Society recommends bracing for Risser stages 0–2 as Risser stage 3 or above is considered low risk. Very few studies have assessed the risk of progression during bracing in Risser stages 3–4. The objective of the current study is to determine if Risser stages 3–4 provide a meaningful cutoff in terms of progression risk in patients with AIS treated with night-time bracing.

Methods
AIS patients treated with night-time brace from 2005 to 2018 with a Cobb angle between 25 and 40 degrees and Risser stages 0–4 were retrospectively included. Curve progression (> 5 degrees increase) was monitored until surgery or SM. Skeletal maturity was defined as either 2 years postmenarchal, no height development or closed ulnar epiphyseal plates on radiographs.

Results
One hundred and thirty-five patients were included (Risser stages 0–2: n = 86 and 3–4: n = 49). Overall, radiographic curve progression occurred in 52% while progression beyond 45 degrees was seen in 35%. The progression rate in the Risser 0–2 group was 60% and 37% in the Risser 3–4 group (p = 0.012). In multivariate logistic regression analysis, adjusted for Risser stages and age, only premenarchal status showed a statistically significant association with progression (OR: 2.68, 95%CI 1.08–6.67).

Conclusion
Risser stage does not provide a clinically meaningful differentiation of progression risk in AIS patients treated with a night-time brace. Risk assessment should include other more reliable measures of skeletal growth potential.
Standard versus low-dose computed tomography for assessment of acetabular fracture reduction using novel step and gap measurement technique
Authors: Robles Abrianna S. , Piple Amit S. , DeSanto Donald J. , Lamb Ashley , Gibbs Stephen J. , Heckmann Nathanael D. , Marecek Geoffrey S. 
Published: June 2023

Abstract
Purpose
Quality of reduction is of paramount importance after acetabular fracture and is best assessed on computed tomography (CT). A recently proposed measurement technique for assessment of step and gap displacement is reproducible but has not been validated. The purpose of this study is to validate a well-established measurement technique against known displacements and to determine if it can be used with low dose CT.

Methods
Posterior wall acetabular fractures were created in 8 cadaveric hips and fixed at known step and gap displacements. CT was performed at multiple radiation doses for each hip. Four surgeons measured step and gap displacement for each hip at all doses, and the measurements were compared to known values.

Results
There were no significant differences in measurements across surgeons, and all measurements were found to have positive agreement. Measurement error < 1.5 mm was present in 58% of gap measurements and 46% of step measurements. Only for step measurements at a dose of 120 kVp did we observe a statistically significant measurement error. There was a significant difference in step measurements made by those with greater and those with fewer years in practice.

Conclusion
Our study suggests this technique is valid and accurate across all doses. This is important as it may reduce the amount of radiation exposure for patients with acetabular fractures.
Outcomes of surgical resection for pulmonary metastasis from pancreatic cancer
Authors: Miyashita Yudai , Ose Naoko , Okami Jiro , Takami Koji , Sakamaki Yasushi , Ikeda Naoki , Hayakawa Masanobu , Higashiyama Masahiko , Kodama Ken , Susaki Yoshiyuki , Funakoshi Yasunobu , Maeda Jun , Shintani Yasushi 
Published: June 2023

Abstract
Purpose
As the number of long-term survivors of pancreatic cancer is expected to increase thanks to recent advances in multidisciplinary treatment and earlier diagnoses of pancreatic cancer, we are likely to encounter more cases of postoperative pulmonary nodules. We analyzed the clinical course and prognosis of resection of pulmonary metastases from pancreatic cancer to clarify the prognostic implication of pulmonary metastasectomy for pancreatic cancer.

Method
We retrospectively analyzed 35 patients who underwent resection of lung metastases after pancreatic cancer surgery. Short- and long-term outcomes and factors associated with the prognosis were analyzed.

Results
The observation period was 20 (range, 1–101) months, with 3- and 5-year survival rates of 88.3% and 64.5% from pancreatectomy and 44.1% and 28.3% from lung resection, respectively. A univariate analysis revealed that a period from pancreatic cancer resection to pulmonary nodule shadow detection of < 15 months was associated with a significantly lower overall survival from pancreatic resection than a longer period. Conversely, histological type, stage, size of lung metastases, and resection technique were not associated with the overall survival.

Conclusion
A long-term prognosis may be expected in some cases with a disease-free interval of ≥ 15 months. Our findings suggest that the disease-free interval may influence the prognosis.
The contralateral-based submental artery island flap: feasibility and oncological safety in oral cancer–related defect reconstruction
Authors: Ma Jingxin , Zhai Xuefan , Huang Min , Li Peiyao , Liang Yujie , Ouyang Daiqiao , Su Yu-xiong , Yang Wei-fa , Liao Guiqing , Zhang Sien 
Published: June 2023

Abstract

Objectives

Oncologic risk is a serious concern of submental artery island flaps. Here, we introduce the contralateral-based submental artery island flap (C-SAIF) and demonstrate its feasibility and long-term oncological safety in reconstructing oral cancer–related defects.

Methods
An anatomical study was performed concentrating on the pedicle length in seven cadavers. Then, a retrospective study was carried out on C-SAIF patients operated on by a single team. The standard surgical technique of C-SAIF was conducted. Outcomes including operative time, length of hospital stay, volume of intraoperative blood loss, and scores of the Multidisciplinary Salivary Gland Society (MSGS) questionnaire were compared with a similar cohort reconstructed with anterolateral thigh free flap (ALTF). In addition, oncological outcomes were evaluated by the 5-year cumulative survival rate between C-SAIF and ALTF patients.

Results
The pedicle length of C-SAIF was sufficient for the flap to be extended to the contralateral oral cavity. Fifty-two patients were included in the retrospective study, and nineteen of them underwent reconstruction with C-SAIF. The operative time of C-SAIF was shorter (p = 0.003), and the intraoperative blood loss was less (p = 0.004) than that of ALTF. There was no difference in MSGS scores. The results of survival analysis revealed comparable survival curves for the two groups in terms of overall survival, disease-specific survival, and disease-free survival.

Conclusion
C-SAIF is a feasible and reliable flap for reconstructing oral cancer–related defects. Moreover, it is an effective island flap to preserve the perforator and pedicle without compromising oncological safety.
Application of the data envelopment analysis technique to measure the environmental efficiency of the 27 countries of the European Union during the period 2012–2020
Authors: Cámara-Aceituno Juan , Hermoso-Orzáez Manuel Jesús , Terrados-Cepeda Julio , Mena-Nieto Ángel , García-Ramos José Enrique 
Published: June 2023

AbstractIn the last decade, we have experienced a changing geopolitical context that has caused changes in the energy context. In addition, human activity contributes to global warming or sea level rising, i.e., climate change. A set of action policies have been implemented to continue fighting against this environmental situation (such as the Paris Agreement, the COP27, or the European Green Deal for 2030); therefore, it is necessary to determine whether we are on the right track. It is compulsory to develop predictive models that accurately analyze the current status and the already path undertaken. To this end, this article analyzes the environmental efficiency of the 27 countries of the European Union (excluding the UK) using the so-called data envelopment analysis (DEA). In particular, economic (GDP and GDP per capita), environmental (CO2 and CH4 emissions), electricity production data, the volume of vehicles, and the industrial production rate of the different countries were collected to calculate environmental efficiency. Once these data were collected, the environmental efficiency was calculated using two methods based on the DEA. The results show that out of the 27 countries, only 12 have a relatively high environmental efficiency, although it could be improved, implementing a set of corrections. However, other countries have a low eco-efficiency performance and they must improve in the coming years. We can highlight that rich countries are closer to achieving high environmental efficiency than less developed countries.
Graphical Abstract
A structured comparison of causal machine learning methods to assess heterogeneous treatment effects in spatial data
Authors: Credit Kevin , Lehnert Matthew 
Published: June 2023

AbstractThe development of the “causal” forest by Wager and Athey (J Am Stat Assoc 113(523): 1228–1242, 2018) represents a significant advance in the area of explanatory/causal machine learning. However, this approach has not yet been widely applied to geographically referenced data, which present some unique issues: the random split of the test and training sets in the typical causal forest design fractures the spatial fabric of geographic data. To help solve this issue, we use a simulated dataset with known properties for average treatment effects and conditional average treatment effects to compare the performance of CF models across different definitions of the test/train split. We also develop a new “spatial” T-learner that can be implemented using predictive methods like random forest to provide estimates of heterogeneous treatment effects across all units. Our results show that all of the machine learning models outperform traditional ordinary least squares regression at identifying the true average treatment effect, but are not significantly different from one another. We then apply the preferred causal forest model in the context of analysing the treatment effect of the construction of the Valley Metro light rail (tram) system on on-road CO2 emissions per capita at the block group level in Maricopa County, Arizona, and find that the neighbourhoods most likely to benefit from treatment are those with higher pre-treatment proportions of transit and pedestrian commuting and lower proportions of auto commuting.
The Current and Retrospective Cognitive Reserve (2CR) survey and its relationship with cognitive and mood measures
Authors: Borella Erika , Ghisletta Paolo , Carbone Elena , Aichele Stephen 
Published: June 2023

AbstractCognitive Reserve (CR) is often assessed with surveys spanning demographic, lifestyle, and socio-behavioral variables. The role of both past and current life experiences on CR has, however, rarely been examined. We developed the Current and Retrospective Cognitive Reserve (2CR) survey to assess classical CR proxies (socio-economic status, engagement in leisure and social activities) and other dimensions of potential importance (family engagement, religious/spiritual activity) both currently (CRc; in later adulthood) and retrospectively (CRr; as recalled from younger adulthood). We administered the 2CR, measures of general cognitive functioning, working memory (WM), crystallized—vocabulary— and fluid—reasoning—intelligence, and depressive symptoms (DS) to 235 community-dwelling Italian adults (ages 55–90 years). We used exploratory and confirmatory factor analyses to examine the 2CR latent structure, and we estimated correlations of its dimensions with cognitive abilities and DS. Analyses confirmed a three-level factor structure with two global CR factors (CRc and CRr) at the top level, dimensional CR factors (socio-economic status, family engagement, leisure activity, social engagement, and religious/spiritual activity) at mid-level and observed items at the lowest level. Item-factor representations partially differed across CRc and CRr. Both CRc and CRr were positively correlated with measures of intelligence, WM and DS, but associations of measures of intelligence were stronger for CRr, whereas associations of WM and DS were slightly stronger for CRc. The 2CR can be considered a reliable survey for assessing CR proxies within a multidimensional, “life stage-dependent” framework insofar as CRc are CRr closely related but also differently associated with intelligence, WM, and DS.
The Implementation of CDC COVID-19 Recommendations for Testing, Isolation, Quarantine and Movement at Emergency Intake Sites of Unaccompanied Children in the United States, April 1–May 31, 2021
Authors: Bustamante Nirma D. , Sauber-Schatz Erin , Lee Deborah , Hailu Kibrten , Liu Yecai , Pezzi Clelia , Yonkman Joel , Gonzalez Jose , Appelgate Allen , Marano Nina , Posey Drew L. , Cetron Martin , Monterroso Edgar 
Published: June 2023

AbstractIn March 2021, Emergency Intake Sites (EIS) were created to address capacity shortfalls during a surge of Unaccompanied Children at the Mexico-United States land border. The COVID-19 Zone Plan (ZP) was developed to decrease COVID-19 transmission. COVID-19 cumulative percent (%) positivity was analyzed to evaluate the impact of the ZP, venue type and bed capacity across EIS from April 1–May 31, 2021. Results: Of 11 EIS sites analyzed, 54% implemented the recommended ZP. The overall % positivity was 2.47% (95% CI 2.39–2.55). The % positivity at EIS with the ZP, 1.83% (95% CI 1.71–1.95), was lower than that at EIS without the ZP, 2.83%, ( 95% CI 2.72–2.93), and showed a lower 7-day moving average of % positivity. Conclusion: Results showed a possible effect of the ZP on % positivity when controlling for venue type and bed capacity in a specific EIS group comparison, indicating that all three variables could have had effect on % positivity. They also showed that smaller intake facilities may be recommendable during public health emergencies.
The Influence of Zn Doping on the Cation Distribution and Antibacterial Activity of CoFe2O4
Authors: Shafaay Amira S. , Ramadan Rania 
Published: June 2023

AbstractNanoparticles of formula Co1-xZnxFe2O4 (x = 0.0, 0.3, and 0.5) were prepared successfully using a citrate-auto-combustion method. This work studies the substitution effect of the Zn2+ ion on the physical, chemical, and structural properties of CoFe2O4. The structure of the prepared samples was determined via X-ray diffraction (XRD) and Fourier transformed infrared spectrometer (FTIR). X-ray diffraction of the investigated samples ensures that all the prepared samples crystallite into single structure. There is a variation of crystallite size with change in Zn concentration as it is observed that the crystallite size increased from 16.01 to 30.56 nm by increasing Zn concentration. The Fourier transform infrared spectra (FTIR) in range (390:4000) Cm−1 were used for studying the elastic properties of the prepared spinel ferrites. It is observed that, by increasing Zn concentration, all elastic moduli increased. The morphological and surface study of the calcined samples was investigated by scanning electron microscopy (SEM) and Gwyddion 2.45 software respectively. The roughness average (Ra) was 35.20 nm at x = 0 and increased to 46.6 nm at x = 0.5. At the room temperature, magnetic behavior of the all studied samples was studied. It is observed that the maximum saturation magnetization was 67.611emu/gm and it was related to Co0.7Zn0.3Fe2O4 while the highest value of exchange bias (HEB) was 2.15 Oe for Co0.5Zn0.5Fe2O4. The antibacterial activity of CoFe2O4, Co0.7Zn0.3Fe2O4, and Co0.5Zn0.5Fe2O4 was successfully tested against Escherichia coli and Staphylococcus aureus bacteria. The highest inhibition zone of Co1-xZnxFe2O4 values was 8 and 7.5 mm for E. coli and S. aureus, respectively, and these values were observed for x = 0.5. Generally, these results exhibit a high possible of ferrites for using in antibacterial applications.