bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical outcome of disorders of gut‐brain interaction in secondary care: A longitudinal study
Authors: Chuah Kee Huat , Hian Wen Xuan , Teoh Aik Tatt , Ling Justin Kwan Yeu , Mahadeva Sanjiv 
Published: April 2023

AbstractBackgroundReal‐world data on the outcome of routine treatment for disorders of gut‐brain interaction (DGBI) in secondary care are lacking.MethodA longitudinal study of consecutive adult patients with various DGBI attending this institution's gastroenterology clinic was conducted. Following 2 years of treatment, the proportion of patients with symptom improvement, details of clinical therapy, factors associated with and the impact of ‘no symptom improvement’ were determined.ResultsA total of 289 patients (median age 68 years; 64.7% females; 28.4% irritable bowel syndrome (IBS), 20.1% functional dyspepsia (FD), 8.7% functional constipation (FC), 42.9% overlap syndrome) were recruited. After 2 years, 66.1% patients reported symptom improvement. Patients with overlap syndrome were less likely to have symptomatic improvement compared to those with a single DGBI (Overlap 55.6% vs IBS 74.4% vs FD 72.4% vs FC 76.0%, p = 0.014). Reassurance was associated with symptom improvement (p < 0.001). On multivariate analysis, overlap syndrome remained significantly associated with a poorer outcome (OR 2.27, 95% CI 1.22–4.25, p = 0.010), while providing reassurance was associated with a positive outcome (OR 0.30, 95% CI 0.16–0.56, p < 0.001).Only 25.6% and 14.9% of patients were referred for a low FODMAP diet and psychiatric intervention respectively. DGBI patients who had ‘no improvement’ were more likely to seek further GI consultations and had more work absenteeism.ConclusionTwo‐thirds of DGBI patients in secondary care showed symptom improvement. Patients who were reassured had better symptom improvement, while those with an overlap syndrome were associated with a poorer outcome, resulting in greater healthcare consultation and work absenteeism.
Pathways between oral health conditions and bullying on adolescents: A 10‐year cohort study
Authors: Bolsson Gabriela Bohrer , Knorst Jessica Klöckner , Rissotto Menegazzo Gabriele , Ardenghi Thiago Machado 
Published: April 2023

AbstractObjectiveTo assess the pathways in which oral health conditions, socioeconomic, and psychosocial factors in childhood can lead to the occurrence of bullying in adolescence.MethodsThis is a 10‐year cohort study conducted with a sample of 639 children in southern Brazil. Oral health conditions (dental caries, dental trauma and malocclusion), sociodemographic and psychosocial characteristics were obtained at baseline (T1) and at follow‐up (T2). General and dental bullying were assessed at T2 using the Bullying Olweus questionnaire and through a question contained in the Child Perception Questionnaire 11–14. Structural equation modelling was used to evaluate the pathways between oral health measures and bullying episodes over time.ResultsA total of 429 students were evaluated at follow‐up. Untreated dental caries were direct and indirectly related with the occurrence of dental bullying at follow‐up and indirectly associated with general bullying at T2. Low socioeconomic status, low sense of coherence and dental bullying presented a direct impact on the occurrence of general bullying at T2.ConclusionsUntreated dental caries are presented as the main oral health predictor of the occurrence of bullying episodes in adolescence.
Textbook outcome was associated with better survival in oral cancer surgery in southern Taiwan
Authors: Chiou Ling‐Jan , Lee Ching‐Chih 
Published: April 2023

AbstractObjectiveTo explore the impact of textbook outcome (TO) on long‐term survival in oral cancer surgery.Subjects and MethodsIn total, 386 patients with tumor resection, neck dissection (ND), and reconstruction between 2011 and 2020 were included. TO was defined as negative margin; adequate ND; no 3‐day emergency room revisit; no 30‐day readmission; and length of stay ≤22 days. Multivariate Cox regression was used to evaluate the impact of TO and 5‐year overall survival (OS).ResultsThe TO rate was 35%. Younger age, subsite in buccal area, Charlson Comorbidity Index Score of 0, higher body mass index, higher hemoglobin, higher albumin, and unilateral ND were associated with TO. 5‐year OS was 70.5% in overall TO patients and 49.0% in non‐TO patients (HR, 0.47; 95% CI, 0.31–0.70; p < 0.001). Non‐TO was associated with an increased mortality rate (aHR, 1.73; 95% CI, 1.14–2.63) after adjusting other factors and the result remained robust with inverse probability of treatment weighting analysis. The impact of TO on OS was more significant in age <60, advanced stage, and diagnosis year before 2018.ConclusionNot achieving TO in oral cancer surgery was associated with worse long‐term outcome. TO could be used as a proxy for surgical quality improvement.
The predictive value of laboratory tests in oro‐maxillofacial infection of different severity
Authors: Wang Baoli , Zhou Qin , Qian Wentao , He Zhiyuan , Yang Zuoyi , Chen Changyu , Zheng Lingyan , Shi Huan 
Published: April 2023

AbstractObjectiveWe aimed to investigate the value of individual laboratory tests and combinations of tests for predicting disease severity.MethodsWe retrospectively reviewed 62 patients with space infections in the oral and maxillofacial head and neck regions. Patients were divided into three groups according to severity. Laboratory tests associated with disease severity were identified.ResultsAs the severity of infection increased, leukocytes, neutrophils, C‐reactive protein (CRP), procalcitonin (PCT), soluble interleukin receptor (sILR) 2, IL6, and creatinine (CR) increased. In the ROC analysis of group 1 (moderate infection) versus group 2 (severe infection), the area under the curve (AUC) values for leukocytes (AUC = 0.724), neutrophils (AUC = 0.714), PCT (AUC = 0.762) and a combination of the 3 tests (AUC = 0.768) suggested a strong predictive value. Furthermore, in the ROC analysis of group 2 (severe infection) versus group 3 (extremely severe infection), the AUC values for CRP (AUC = 0.84), PCT (AUC = 0.799), sIL2R (AUC = 0.937), IL6 (AUC = 0.863) and a combination of the four tests (AUC = 0.943) suggested a strong predictive value.ConclusionsLeukocytes, neutrophils, and PCT were associated with multispace infection and high severity. CRP, PCT, sIL2R, and/or IL6 were associated with extremely severe infections occurring in the oral and maxillofacial head and neck regions.
The Czech version of the life satisfaction index for the third age—short form (LSITA‐SF12): Psychometric properties
Authors: Bužgová Radka , Bobčíková Katka , Kozáková Radka , Zeleníková Renáta 
Published: April 2023

AbstractBackgroundEvaluation of life satisfaction of older people using standardised tools can play a crucial role in evaluating the effectiveness of policy measures aimed at mitigating the effects of population aging.ObjectivesThe aim of the study was to verify the psychometric properties of the Czech version of a 12‐item scale (the Life Satisfaction Index for the Third Age) for older people living in the community.MethodsThe research involved 1113 older people from the Moravian–Silesian Region over 60 years of age living in a home environment. For the newly created Czech version of LSITA‐SF12, we tested validity (construct validity and convergent validity) and reliability (internal consistency).ResultsWe confirmed a single‐factor model for the LSITA‐SF12 scale (χ2 = 71.33, p <  .001, CFI = 0.995, TLI = 0.994, RMSEA = 0.065, SRMR = 0.056, GFI = 0.999) by confirmatory factor analysis and load factor analysis (values of explorations ≥0.45). The internal consistency of the scale was satisfactory (α = 0.878). Furthermore, there was a medium correlation rate (r = 0.592; p <  .001) between the overall score of the LSITA‐SF and quality‐of‐life score (OPQoL‐Brief).ConclusionsWe found the Czech version of the LSITA‐SF12 questionnaire to have satisfactory psychometric properties. The questionnaire is suitable for use in research and clinical practice to evaluate the effectiveness of preventive measures.Clinical Trial Registration: ClinicalTrials.gov. PRS Protocol Registration and Results System; NCT05637177.Implication for practiceThe LSITA_SF12 questionnaire can beadministered by a community gerontological nurse and can be used in clinicalpractice and research.
Total Hip Arthroplasty or Arthroscopy for Pigmented Villonodular Synovitis of the Hip: A Retrospective Study with 3‐Year Follow‐Up at Minimum
Authors: Li Tao , Mei Lu , Xu Yang , Cao YuanYiNuo , Shi XiaoJun , Chen Gang , Li Jian 
Published: April 2023

ObjectivePigment Villonodular synovitis of the hip, a rare pain proliferation of the synovium, was treated successfully with total hip arthroplasty and arthroscopy. Most recent results come from small case series with no study comparing arthroscopy and arthroplasty. In this study, we aimed to show and compare the clinical outcomes of arthroscopy and total hip arthroplasty (THA) in pigment Villonodular synovitis of the hip.MethodsThis was a retrospective clinical trial with data from patients with pigment Villonodular synovitis of the hip between 2010 and 2019. The study included 17 patients in the THA group, and 20 patients in the arthroscopy group. The clinical outcomes were evaluated at 3, 6, and 12 months, at 1 and 2 years, and every 5 years afterward. The clinical efficacy was measured using the Harris hip scores (HHSs) and visual analogue scale (VAS) score.ResultsThe mean HHS improved from 45.24 ± 10.36 to 78.94 ± 19.11 in the THA group (t = −6.394, P = 0.000) and 45.30 ± 11.08 to 71.60 ± 19.78 (t = −5.187, P = 0.000) in the arthroscopy group from pre‐operation to the final follow‐up. There is no significant difference between the two groups (t = 1.051, P = 0.301). The mean VAS improved from 3.65 ± 0.79 to 0.35 ± 0.70 (t = 12.890, P = 0.000) in the THA group and 4.05 ± 0.94 to 1.35 ± 1.79 (t = 5.979, P = 0.001) in the arthroscopy group postoperatively. There is no significant difference between the two groups (t = 1.329, P = 0.193). Recurrence of PVNS was diagnosed in four patients (20%) of the arthroscopy group and they underwent THA after arthroscopy, and the mean interval was 44.25 ± 6.98 months. All patients reached level 5 muscle strength by the final follow‐up. All the patients' buckling ranges were over 105 degrees. Their internal and external hip rotation was over 15 degrees. Their hip adduction was over 20 degrees, and abduction over 30 degrees.ConclusionBoth THA and arthroscopy in the setting of PVNS can improve patients' function and lead to a low rate of local recurrence. By selecting patients well for each approach, one can expect a reasonable result.
Proceedings of the 10th Pediatric Dermatology Research Alliance (PeDRA) Annual Conference
Authors: Dykman Morgan , Coughlin Carrie , Cotton Colleen , Hawryluk Elena , Kirkorian A. Yasmine , Silverman Robert , Castelo‐Soccio Leslie , Yu Jiade , Fernández Faith Esteban , Siegel Michael , Arkin Lisa , Ramien Michele L. 
Published: April 2023

AbstractThe 10th Pediatric Dermatology Research Alliance (PeDRA) Annual Conference occurred November 3–5, 2022 in Bethesda, Maryland. This conference was the first in‐person PeDRA conference after 2 years of a virtual format due to COVID‐19. Fittingly, given the effects of the pandemic, the conference theme was “Reimagining Community.” The conference included presentations and panel sessions on finding individual and collective purpose, leveraging community in pursuit of a shared goal, and creating a community of resources in collaboration with NIH. The goal of this meeting was to connect clinicians, basic scientists, patients, patient advocates, and industry partners. The reimagined community of pediatric dermatology research is a synergistic space for all members to better understand, prevent, treat, and cure dermatologic diseases and conditions in children. This two‐and‐a‐half‐day conference with over 300 attendees featured educational seminars including a keynote address, didactic lecture and panel sessions, skill‐building workshops, 13 topic‐specific breakout sessions, and an interactive poster session where 108 active and finished research projects could be discussed.
Field surveys indicate taxonomically diverse Pectobacterium species inducing soft rot of vegetables and annual crops in Iran
Authors: Parvin S. Mohammad Reza , Taghavi S. Mohsen , Osdaghi Ebrahim 
Published: April 2023

AbstractSoft rot‐inducing bacterial pathogens are considered among the main biotic constraints on vegetables and annual crops. Most of the bacterial soft rot pathogens are members of Pectobacterium spp. and Dickeya, with the former genus encompassing a continuously increasing number of species varying in geographic distribution and host of isolation. In Iran, Pectobacterium species have rarely been investigated using high‐throughput nucleotide sequence‐based techniques, leaving the genetic diversity of these pathogens mostly undetermined. During 2021, vegetables and annual crops with symptoms of soft rot and maceration were collected from Fars, Hamedan, Isfahan, Khuzestan and Kohgiluyeh‐Boyer‐Ahmad provinces of Iran. Forty‐four pectinolytic bacterial strains were isolated from symptomatic tissues of bell pepper, cabbage, carrot, lettuce, potato and zucchini. The bacterial strains were subjected to pathogenicity and host range assays, specific PCR tests and phylogenetic analysis of three housekeeping genes (dnaX, gapA and leuS). All strains were pathogenic on their host of isolation. Among the 44 pectinolytic strains, 26 strains were identified as members of Pectobacterium based on PCR using the primer pair Y1/Y2. Multilocus sequence analysis confirmed the latter bacterial strains belonging to the genus Pectobacterium and revealed that the strains scattered into four species: P. brasiliense (five strains), P. carotovorum (eight strains), P. polaris (five strains) and P. versatile (eight strains). P. polaris and P. versatile have not previously been reported in the country. Host range assays showed that P. brasiliense and P. carotovorum have a broader host range than the other two species.
Dose–response relation between the duration of a cognitively challenging bout of physical exercise and children's cognition
Authors: Anzeneder Sofia , Zehnder Cäcilia , Schmid Jürg , Martin‐Niedecken Anna Lisa , Schmidt Mirko , Benzing Valentin 
Published: April 2023

AbstractAcute bouts of physical exercise have the potential to benefit children's cognition. Inconsistent evidence calls for systematic investigations of dose–response relations between quantitative (intensity and duration) and qualitative (modality) exercise characteristics. Thus, in this study the optimal duration of an acute cognitively challenging physical exercise to benefit children's cognition was investigated, also exploring the moderating role of individual characteristics. In a within‐subject experimental design, 104 children (Mage = 11.5, SD = 0.8, 51% female) participated weekly in one of four exergaming conditions of different durations (5, 10, 15, 20 min) followed by an Attention Network task (ANT‐R). Exergame sessions were designed to keep physical intensity constant (65% HRmax) and to have a high cognitive challenge level (adapted to the individual ongoing performance). Repeated measures ANOVAs revealed a significant effect of exercise duration on reaction times (RTs; p = 0.009, ƞ2p = 0.11), but not on response accuracy. Post hoc analyses showed faster information processing speed after 15 min of exercise compared to 10 min (p = 0.019, ƞ2p = 0.09). Executive control, alerting and orienting performances and interactions were unaffected by exercise duration (ps > 0.05). Among individual characteristics, habitual physical activity moderated duration effects on RTs. For more active children, exercise duration influenced the interaction between executive control and orienting (p = 0.034; ƞ2p = 0.17) with best performances after the 15 min duration. Results suggest that an acute 15 min cognitively high‐challenging bout of physical exercise enhances allocable resources, which in turn facilitate information processing, and—for more active children only—also executive processes. Results are interpreted according to the arousal theory and cognitive stimulation hypothesis.
The journey of staying: A transitional and mobility perspective on the staying rural preferences of rural young adults
Authors: Hofstede Henk , Salemink Koen , Haartsen Tialda 
Published: April 2023

AbstractThis article presents insight into rural young adults’ reflections on their past, present and future staying rural preferences (transitional perspective) and how they relate to their experiences and connections outside the rural home area (mobility perspective). Using a biographical approach, we conducted 12 semi‐structured interviews with young employed adults living with their parents or alone in two rural areas in the Netherlands and Northern Ireland. Their transitional perspectives, which were agent‐centred, revealed that staying rural preferences do not evolve as a uniform process, fluctuating instead between ‘messy’ periods of stability and instability, entailing multiple alternations between deliberate and ‘just‐happened’ periods. In line with the ‘new mobilities paradigm’, the participants’ mobility perspectives confirmed the relevance of past residential experiences and current non‐residential mobility for analysing staying preferences. The article concludes that staying rural is a complex, (unstable) evolving, spatially relational and (only partly) conscious process.
Out of the ESCPE room: Emerging roles of endosomal SNX‐BARs in receptor transport and host–pathogen interaction
Authors: Simonetti Boris , Daly James L. , Cullen Peter J. 
Published: April 2023

AbstractSeveral functions of the human cell, such as sensing nutrients, cell movement and interaction with the surrounding environment, depend on a myriad of transmembrane proteins and their associated proteins and lipids (collectively termed “cargoes”). To successfully perform their tasks, cargo must be sorted and delivered to the right place, at the right time, and in the right amount. To achieve this, eukaryotic cells have evolved a highly organized sorting platform, the endosomal network. Here, a variety of specialized multiprotein complexes sort cargo into itineraries leading to either their degradation or their recycling to various organelles for further rounds of reuse. A key sorting complex is the Endosomal SNX‐BAR Sorting Complex for Promoting Exit (ESCPE‐1) that promotes the recycling of an array of cargos to the plasma membrane and/or the trans‐Golgi network. ESCPE‐1 recognizes a hydrophobic‐based sorting motif in numerous cargoes and orchestrates their packaging into tubular carriers that pinch off from the endosome and travel to the target organelle. A wide range of pathogens mimic this sorting motif to hijack ESCPE‐1 transport to promote their invasion and survival within infected cells. In other instances, ESCPE‐1 exerts restrictive functions against pathogens by limiting their replication and infection. In this review, we discuss ESCPE‐1 assembly and functions, with a particular focus on recent advances in the understanding of its role in membrane trafficking, cellular homeostasis and host–pathogen interaction.
Negating the Galvin property
Authors: Benhamou Tom , Garti Shimon , Poveda Alejandro 
Published: April 2023

AbstractWe investigateGalvin's property, a striking feature of the filter of closed unbounded subsets of an infinite cardinal. In particular, we continue the work of Abraham and Shelah (J. Symbolic Logic51(1986), no. 1, 180–189) by developing new methods to handle singular cardinals. In addition, the paper explores some new strengthenings of Galvin's property and analyzes their connections with other classical properties of filters.
QPEC: QGIS Toolkit for Evaluating Geospatial Data Positional Accuracy according to the Brazilian Cartographic Accuracy Standard
Authors: Elias Elias Nasr Naim , Giehl Samoel , Amorim Fabricio Rosa , Schmidt Marcio Augusto Reolon , Camboim Silvana Philippi , Fernandes Vivian De Oliveira 
Published: April 2023

This paper presents the development of a QGIS plugin to support evaluating the planimetric positional quality for point and linear features based on the metrics established by Brazilian legislation. For this purpose, we used the QGIS environment Graphical Modeler, which consists of an interface to concatenate a series of processes into a single algorithm. The set of tools, called QPEC, allows for performing the statistical tests from the automatic identification of the sample size and discrepancies. In order to demonstrate the implemented functionalities, a case study was carried out. In this illustrative example, the vector files from the Cartographic and Cadastral System of the Municipality of Salvador - BA (SICAD) were the reference data, and their homologous OpenStreetMap (OSM) features were the analysed database. The results obtained are presented in the attributes table. In addition, the spatial distribution of the discrepancies is visualised through the visual variable colour value in a quartile classification. The creation of this toolset corroborates the feasibility of developing more visual, automated and complete interfaces to support users of geospatial data in analysing the quality of the information available, especially when it involves free applications with open-source code.
Biocompatible Microemulsions Based on Oleic Acid Modified with Piperidinium Surfactants
Authors: Mirgorodskaya A. B. , Kushnazarova R. A. , Lenina O. A. , Petrov K. A. , Zakharova L. Ya. 
Published: April 2023

Abstract
A series of microemulsions based on oleic acid and Tween 80, modified with piperidinium surfactants, have been obtained and characterized. The effect of additives on the size, stability, and solubilization effect of the formed systems with respect to hydrophilic (rhodamine B) and hydrophobic (indomethacin) substances have been investigated. Varying of the components ratio has allowed preparation of the microemulsions with strongly different viscosity: from easy-flowing formulations to gels. Kinetic parameters describing release of the substrates from the microemulsions have been obtained. In vivo tests of the anti-inflammatory action of the microemulsions loaded with indomethacin have shown that the presence of piperidinium surfactants enhances the therapeutic effect of the drug.