bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shock Isolation of Light Vehicle Suspension by Modified Eye Leaf Spring
Authors: Ashiqur Rahman Muhammad , Ibrahim Md. Sikander , Tonmoy Ahmad Abdullah , Mridha MD. AL-Hasan 
Published: August 2023

Background:
Rickshaws are a popular and inexpensive mode of transportation in Bangladesh
for short-distance travel. However, the eye leaf spring in a typical rickshaw suspension system does not
provide adequate shock isolation. The coil spring-damper suspension system is more effective, but is
costly and not affordable for most manufacturers. Thus, the goal is to modify the eye leaf spring to be
inexpensive but a safe and comfortable suspension.

Aim:
The study aimed to modify the material and structure of the leaf spring to limit the stiffness and the
shock energy within a certain range suitable for the rickshaw’s suspension. The focus of the study was on
modifying the spring structure, which could be cost-effective.

Methods:
In this study, flexible bolted joints and EVA sheets have been used to change the spring structure.
The study compared the performance of the modified spring with the typical eye leaf spring.

Results:
The modified eye leaf spring provided improved shock isolation and a more comfortable ride
compared to the typical eye leaf spring. The changes made to the spring, such as the use of flexible bolted
joints and EVA sheets, limited the stiffness and shock energy within a certain range suitable for the rickshaw’s
suspension. The modified spring was also found to be cost-effective.

Conclusion:
The study has demonstrated the feasibility of using a modified eye leaf spring for light vehicle
suspensions, specifically for rickshaws. The modifications made to the spring structure, such as using
flexible bolted joints and EVA sheets, provided improved shock isolation, a more comfortable ride, and
cost-effectiveness. The modified spring offers an inexpensive solution for manufacturers to produce rickshaws
with a safer and more comfortable suspension system.
Review on the Effective Implications of Plant-generated Polyphenols as
Novel Therapeutic Agents against Neurodegenerative Diseases
Authors: Adhikari Diptayan , Biswas Jayati , De Bitihotra , Kumar Pathak Bani 
Published: August 2023

Abstract:
Various neurodegenerative diseases have become a serious threat to human health all
around the world. The progressive loss of functionality of active neurons causes neurodegenerative
disease. Current research suggests that plant-derived foods, such as fruits and vegetables, are a good
source of natural polyphenols, which can be effective in reducing the risk factors of neurodegenerative
diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease
(HD), etc. These polyphenols exhibit cognitive repair and can reduce the production of reactive oxygen
species (ROS) to establish neuroprotection. Various animal models were developed to understand
the neuromodulatory and therapeutic activities of polyphenols for the treatment of AD, PD,
HD, etc. Moreover, polyphenols indirectly modulate the gut microbiome to generate neuroprotection.
Although there is a disadvantage to the low oral bioavailability of these polyphenols, the conjugation
can enhance the efficiency of these compounds with nanoparticles. The present review
gives an outline of plant-generated polyphenols and highlights their effects in the treatment of various
neurodegenerative diseases. As a result, the prevention of aging-related disorders through natural
products certainly shows excellent therapeutic efficiency soon. For this study, various reviews as
well as original research articles from PubMed describing the possible therapeutic effects of dietary
polyphenols to cure neurodegenerative diseases are used.
Neoteric Role of Quercetin in Visual Disorders
Authors: Khil Noor Hassan Sulaiman , Sharma Shaweta , Sharma Pramod Kumar , Alam Md Aftab 
Published: August 2023

Abstract:
Flavonoids are a family of secondary metabolites found in plants and fungi that exhibit
strong antioxidant properties and low toxicity, making them potential candidates for medicinal
use. Quercetin, a flavonoid present in various plant-based foods, has gained attention for its numerous
biological benefits, including anti-inflammatory, anti-fibrosis, and antioxidant properties.
The ocular surface research community has recently focused on quercetin’s therapeutic potential
for managing ocular diseases, such as dry eye, keratoconus, corneal inflammation, and neovascularization.
In this paper, we discuss the role of quercetin for ocular disease prevention, highlighting
its fundamental characteristics, common biological properties, and recent applications. By reviewing
the latest research conducted in the last 10 years which was focused on novel herbal formulations
for ocular diseases, we aim to provide insights into the role of quercetin in managing
ocular diseases and offer perspectives on its potential as a therapeutic agent.
Psychopharmacological Treatment of Depression and Anxiety and
their Different Drug Delivery Targets
Authors: Sharma Aditya , Alam Md. Aftab , Kaur Awaneet , Sharma Shaweta , Yadav Shikha 
Published: August 2023

Abstract:
General practitioners observe a high prevalence of anxiety and depression symptoms.
Depressed or anxious patients frequently develop both conditions. The symptoms of both
diseases may be present at the same time. There has been numerous studies on higher levels of
depression, bipolar disorder II, and mixed depression. So, we ended up reviewing different
drug delivery targets. Even at low dosages, antidepressants were better absorbed and were
more effective when given by the nose. In this review, we focused on cutting-edge methods for
intranasal antidepressant delivery vehicles. Consequently, it seems that drugs that are sufficiently
effective, have fewer side effects, and are less expensive. The researchers in this metaanalysis
set out to determine whether or not they have been used successfully in traditional
medicine to treat depression in human or animal studies.
Modified Extreme Learning Machine Algorithm with Deterministic
Weight Modification for Investment Decisions based on Sentiment
Analysis
Authors: Kalaiselvi K. , David Vasantha Kalyani 
Published: August 2023

Background:
A significant problem in economics is stock market prediction. Due to the
noise and volatility, however, timely prediction is typically regarded as one of the most difficult
challenges. A sentiment-based stock price prediction that takes investors' emotional trends into
account to overcome these difficulties is essential.

Objective:
This study aims to enhance the ELM's generalization performance and prediction accuracy.

Methods:
This article presents a new sentiment analysis based-stock prediction method using a
modified extreme learning machine (ELM) with deterministic weight modification (DWM) called
S-DELM. First, investor sentiment is used in stock prediction, which can considerably increase the
model's predictive power. Hence, a convolutional neural network (CNN) is used to classify the user
comments. Second, DWM is applied to optimize the weights and biases of ELM.

Results:
The results of the experiments demonstrate that the S-DELM may not only increase prediction accuracy but also shorten prediction time, and investors' emotional tendencies are proven to
help them achieve the expected results

Conclusion:
The performance of S-DELM is compared with different variants of ELM and some
conventional method
Exploring Perceptions About Paracetamol, Tramadol, and Codeine on Twitter Using Machine Learning: Quantitative and Qualitative Observational Study
Authors: Carabot Federico , Donat-Vargas Carolina , Santoma-Vilaclara Javier , Ortega Miguel A , García-Montero Cielo , Fraile-Martínez Oscar , Zaragoza Cristina , Monserrat Jorge , Alvarez-Mon Melchor , Alvarez-Mon Miguel Angel 
Published: August 2023

Background
Paracetamol, codeine, and tramadol are commonly used to manage mild pain, and their availability without prescription or medical consultation raises concerns about potential opioid addiction.

Objective
This study aims to explore the perceptions and experiences of Twitter users concerning these drugs.

Methods
We analyzed the tweets in English or Spanish mentioning paracetamol, tramadol, or codeine posted between January 2019 and December 2020. Out of 152,056 tweets collected, 49,462 were excluded. The content was categorized using a codebook, distinguishing user types (patients, health care professionals, and institutions), and classifying medical content based on efficacy and adverse effects. Scientific accuracy and nonmedical content themes (commercial, economic, solidarity, and trivialization) were also assessed. A total of 1000 tweets for each drug were manually classified to train, test, and validate machine learning classifiers.

Results
Of classifiable tweets, 42,840 mentioned paracetamol and 42,131 mentioned weak opioids (tramadol or codeine). Patients accounted for 73.10% (60,771/83,129) of the tweets, while health care professionals and institutions received the highest like-tweet and tweet-retweet ratios. Medical content distribution significantly differed for each drug (P<.001). Nonmedical content dominated opioid tweets (23,871/32,307, 73.9%), while paracetamol tweets had a higher prevalence of medical content (33,943/50,822, 66.8%). Among medical content tweets, 80.8% (41,080/50,822) mentioned drug efficacy, with only 6.9% (3501/50,822) describing good or sufficient efficacy. Nonmedical content distribution also varied significantly among the different drugs (P<.001).

Conclusions
Patients seeking relief from pain are highly interested in the effectiveness of drugs rather than potential side effects. Alarming trends include a significant number of tweets trivializing drug use and recreational purposes, along with a lack of awareness regarding side effects. Monitoring conversations related to analgesics on social media is essential due to common illegal web-based sales and purchases without prescriptions.
Long-Term Benefits of an Integrated Continuous Glucose Monitoring and Insulin Pump System for Emergency Admissions, Hospitalization, and Metabolic Control in a Cohort of People With Diabetes: Retrospective Cohort Study
Authors: O'Meara Miguel , Mateus Acuña Juan Camilo , Uribe Andrea 
Published: August 2023

Background
There is evidence in the literature that the use of sensor-augmented insulin pumps in patients with high-complexity diabetes improves metabolic control. However, there is no long-term information on clinical outcomes such as hospitalization or admission to the emergency room. This study describes outcomes for metabolic control, incidence of hospitalizations, and emergency room visits in a specific population using this technology.

Objective
We aimed to assess long-term glycemic and clinical outcomes after the use of continuous subcutaneous insulin infusion and continuous glucose monitoring in people with diabetes.

Methods
A retrospective cohort study was carried out in patients with diabetes previously treated with an intensive insulin regimen at a specialized diabetes treatment center who required a sensor-augmented insulin pump due to nonoptimal glycemic control. Glycated hemoglobin, severe hypoglycemic episodes, nonsevere hypoglycemic episodes, perception of hypoglycemia, and the incidence of emergency room visits and hospitalizations before and after treatment were evaluated.

Results
Between January 2013 and August 2020, 74 patients with a median age of 36 (IQR 27-46) years were included in the study with a median 4 (IQR 2-7) years of follow-up. We found a statistically significant reduction in glycated hemoglobin (8.35% vs 7%; P<.001), nonsevere hypoglycemic episodes (71/74, 96% vs 62/74, 84%; P=.01), emergency room visits (42/73, 58% vs 4/62, 6%; P<.001), and hospitalizations (36/72, 50% vs 10/72, 14%; P<.001) after use of continuous subcutaneous insulin infusion.

Conclusions
The use of a sensor-augmented insulin pump associated with a strict follow-up program for patients with high-complexity diabetes led to a significant and sustained reduction in glycated hemoglobin and hypoglycemic episodes, as well as in the rate of emergency room visits and hospitalizations. These results encourage the adoption of this technology in patients who do not achieve metabolic control with optimal management of diabetes.
Selfie-Related Incidents: Narrative Review and Media Content Analysis
Authors: Cornell Samuel , Brander Robert , Peden Amy 
Published: August 2023

Background
Selfie-related injury has become a public health concern amid the near ubiquitous use of smartphones and social media apps. Of particular concern are selfie-related deaths at aquatic locations; areas often frequented because of their photogenic allure. Unfortunately, such places exhibit hazards inherent with their environment.

Objective
This study aimed to ascertain current evidence regarding selfie-related injuries and recommended risk treatment measures in the academic literature as well as how selfie-related injuries and deaths were being reported by the media, allowing us to identify key challenges facing land managers and public health practitioners in mitigating selfie-related injuries and deaths.

Methods
Between October and December 2022, we performed a narrative review of peer-reviewed literature published since January 2011. Literature was screened to identify causal factors implicated in selfie-related deaths and injuries, as well as risk treatments recommended. Furthermore, we used an environmental scan methodology to search for media reports of selfie-related injuries and deaths at aquatic locations in Australia and the United States. Individual cases of selfie-related aquatic injuries and deaths sourced from news reports were analyzed to assess epidemiological characteristics, and a thematic content analysis was conducted to identify key themes of news reporting on selfie-related deaths and injuries.

Results
In total, 5 peer-reviewed studies were included. Four studies identified falls from height as the most common injury mechanism in selfie incidents. Drowning was the second most common cause of death. Recommended risk treatments were limited but included the adoption of “no selfie zones,” physical barriers, signage, and provision of information on dangerous locations to social media users. In total, 12 cases were identified from media reports (4 injuries and 8 fatalities; 7 in Australia and 5 in the United States). The mean age of the reported victims was 22.1 (SD 6.93) years with victims more likely to be female tourists. Content analysis revealed 3 key themes from media reports: “blame,” “warning,” and “prevention and education.” Few media reports (n=8) provided safety recommendations.

Conclusions
The selfie-related incident phenomenon should be viewed as a public health problem that requires a public health risk communication response. To date, little attention has been paid to averting selfie-related incidents through behavior change methodologies or direct messaging to users, including through social media apps. Although previous research has recommended “no selfie zones,” barriers, and signage as ways to prevent selfie incidents, our results suggest this may not be enough, and it may be prudent to also engage in direct safety messaging to social media users. Media reporting of selfie incidents should focus on preventive messaging rather than blame or warning.
Pengaruh Minat Belajar dan Latar Belakang Ekonomi Orang Tua Terhadap Keinginan Siswa SMK Negeri 4 Solok Selatan untuk Melanjutkan Ke Perguruan Tinggi
Authors: Naufal Alifka  , Putra Dwi Sudarno , Wagino  , Arif Ahmad , Rusdiman  
Published: August 2023

Pendidikan SMK merupakan salah satu bentuk pendidikan formal yang fokus pada pendidikan kejuruan di tingkat menengah, dan sekolah ini berorientasi pada dunia kerja. Walaupun begitu, lulusan SMK juga memiliki kesempatan untuk melanjutkan pendidikan ke jenjang perguruan tinggi sesuai dengan bidang kejuruan yang mereka pilih. Diharapkan bahwa melalui pendidikan lanjutan ini, mereka dapat lebih mengembangkan diri dan mampu bersaing serta beradaptasi di era global. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh minat belajar siswa dan status sosial ekonomi orang tua mempengaruhi keinginan siswa untuk melanjutkan ke perguruan tinggi. Penelitian ini menggunakan metode kuantitatif dan data utama dikumpulkan melalui kuesioner. Hasil penelitian menunjukkan bahwa minat belajar siswa dan status sosial ekonomi orang tua memiliki pengaruh yang signifikan terhadap keinginan siswa untuk melanjutkan ke perguruan tinggi yang bernilai 73,1%.
SMK education is a form of formal education that emphasizes secondary-level vocational education and is oriented toward the workplace. Nonetheless, SMK graduates have the option to continue their education at the tertiary level in accordance with their chosen vocational discipline. Through this advanced education, it is anticipated that they will be able to develop further and be able to compete and adapt in the global era. The purpose of this study was to determine the impact of students' interest in learning and their parents' socioeconomic status on their motivation to continue their education in college. This study employed quantitative methods, and questionnaires were used to capture the majority of the data. Students' interest in learning and their parents' socioeconomic status had a significant impact on their desire to pursue postsecondary education, which was 73.1%.
Evaluation of a 3-D printed drill guide to facilitate fluoroscopic-assisted Kirschner wire placement for minimally invasive iliosacral screw placement in dog cadavers
Authors: Deveci Mehmet Zeki Y. , Lewis Daniel D. , Lederer XiaoXiao J. 
Published: August 2023

Abstract

OBJECTIVE
To evaluate the ease and accuracy of using a 3-D printed (3-DP) drill guide to insert Kirschner wires through the ilium and into the sacral body in preparation for minimally invasive iliosacral screw placement in dog cadavers.

ANIMALS
10 dog cadavers weighing 20 to 30 kg (mean ± SD, 24.5 ± 5 kg).

METHODS
Kirschner wires were placed using a limited approach to the lateral ilium. Fluoroscopy was used in freehand and 3-DP drill guide application groups to facilitate the placement of a 1.0-mm Kirschner wire that was over-drilled using a 2.5-mm cannulated drill bit. Kirschner wires were placed using a 3-DP drill guide on 1 hemipelvis and freehand wire placement was done on the contralateral hemipelvis. Postprocedural CTs were obtained, and 2-D and 3-D analyses were performed. The Student t-test and Wilcoxon rank sum test were used to compare groups. A Pearson correlation coefficient was performed to evaluate the in-group correlation.

RESULTS
Likert scores that assessed the ease of the procedure were significantly greater (P = .04) and the incision length was significantly shorter (P = .016) in the 3-DP drill guide group compared with the freehand group. The time of the procedure, the number of attempts to obtain accurate Kirschner wire placement, and fluoroscopy images did not differ (P > .05) between application groups. Drill tracks were primarily confined to the sacral body, with minor projected screw thread cortical breeches occurred in 1 cadaver in the freehand group and 2 cadavers in the 3-DP drill guide group.

CLINICAL RELEVANCE
The 3-DP drill guide simplified appropriate iliosacral Kirschner wire placement through a smaller incision compared with freehand drilling and would appear to be an efficient, practical instrument to facilitate accurate fluoroscopic-assisted screw placement when stabilizing sacroiliac luxations in dogs.
Defining a species-specific K constant in American Bullfrogs (Lithobates catesbeianus) through use of computed tomography
Authors: Calcagno Jaime N. , Nelson Nathan C. , Duke Elizabeth G. , Harrison Tara M. 
Published: August 2023

Abstract

OBJECTIVE
To use CT measurements to define the body surface area (BSA) formula in American bullfrogs (Lithobates catesbeianus) and calculate the species-specific shape constant (K) to suggest chemotherapeutic doses.

ANIMALS
12 American bullfrogs owned by the North Carolina State College of Veterinary Medicine Department of Laboratory Animal Resources underwent CT scans without anesthesia or sedation in November 2022.

METHODS
As part of this prospective study, each American bullfrog underwent a complete physical exam and CT scan. 3-D surface models were created using CT data, and the resulting measurements were used for BSA calculations. Animals were grouped by sex. Nonlinear regression analysis of BSA versus body weight was performed, and a species-specific formula was derived for calculating BSA in American bullfrogs.

RESULTS
The mean body weight of the bullfrogs was 354 grams. The mean CT-derived BSA was 414.92 cm2. The calculated K constant was 8.28 for the 12 American bullfrogs, and the CT-derived BSA formula was BSA in cm2 = 8.28 X (body weight in g)2/3. The K constant was 8.07 for females and 8.44 for males and was not significantly different between sexes (P = .5).

CLINICAL RELEVANCE
Results indicated that the species-specific K constant for American bullfrogs is 8.28. This is the first calculated K constant that exists for amphibians to our knowledge.
Importance of early diagnosis, multimodal treatment, and a multidisciplinary approach for oral eosinophilic lesions in cats: a retrospective study of 38 cases (1997–2022)
Authors: Soltero-Rivera Maria , Quinones Marilucy Pilar Del Toro , Arzi Boaz , Vapniarsky Natalia 
Published: August 2023

Abstract

OBJECTIVE
This study aimed to characterize the clinical and histopathologic features of oral eosinophilic lesions in cats.

Animals
38 client-owned cats.

METHODS
The medical records database was searched for cats diagnosed with histologically confirmed eosinophilic oral lesions from 1997 to 2022. Information such as medical history, lifestyle factors, clinical presentation, and radiographic and histopathologic features was included for 38 client-owned cats. Response to treatment and long-term follow-up was also recorded.

RESULTS
The most affected site was the tongue, with approximately half of the affected cats showing signs of oral discomfort and difficulty eating or breathing. Ulcerative lesions were common, with two-thirds of patients showing more than 1 site affected. Histological samples had a classic appearance, whereas some had an atypical appearance characterized by degenerate collagen clusters associated with multinucleated giant cells. A significant association between lesion location, clinical signs, and prognosis was also found, with patients with palatal lesions being more likely to show respiratory signs and less likely to respond to treatment. Finally, treatment response was observed in most cases within 2 months of commencing therapy combining antimicrobial, and immunosuppressive treatment.

CLINICAL RELEVANCE
The results of this study demonstrate the importance of early diagnosis and treatment of cases of oral eosinophilic lesions in cats. Additionally, it emphasizes the need for a multimodal approach to treatment which should include antibacterial therapy. Of no less importance is that other systems may be affected in these patients, warranting a multidisciplinary approach to their management.