bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glacier retreat, dynamics and bed overdeepenings of Parkachik Glacier, Ladakh Himalaya, India
Authors: Rana Ajay Singh , Kunmar Pankaj , Mehta Manish , Kumar Vinit 
Published: July 2023

AbstractThis study describes the morphological and dynamic changes of Parkachik Glacier, Suru River valley, Ladakh Himalaya, India. We used medium-resolution satellite images; CORONA KH-4, Landsat and Sentinel-2A from 1971–2021, and field surveys between 2015 and 2021. In addition, we used the laminar flow-based Himalayan Glacier Thickness Mapper and provide results for recent margin fluctuations, surface ice velocity, ice thickness, and identified glacier-bed overdeepenings. The results revealed that overall the glacier retreated by −210.5 ± 80 m with an average rate of 4 ± 1 m a−1 between 1971 and 2021. Whereas a field study suggested that the glacier retreat increased to −123 ± 72 m at an average rate of −20 ± 12 m a−1 between 2015 and 2021. Surface ice velocity was estimated using COSI-Corr on the Landsat data. Surface ice velocity in the lower ablation zone was 45 ± 2 m a−1 in 1999–2000 and 32 ± 1 m a−1 in 2020–2021, thus reduced by 28%. Further, the maximum thickness of the glacier is estimated to be ~441 m in the accumulation zone, while for glacier tongue it is ~44 m. The simulation results suggest that if the glacier continues to retreat at a similar rate, three lakes of different dimensions may form in subglacial overdeepenings.
Advancing theorizing about fast-and-slow thinking: The interplay between fast and slow processing
Authors: Fabio Rosa Angela , Caprì Tindara 
Published: July 2023

Abstract
We agree with the author's working model, but we suggest that (a) the classical distinction between fast and slow processes as separable processes can be softened, and (b) human performance might result from an interplay between fast and slow processing and these processes may be mediated by systems that evolve to satisfy the need for operation in a complex environment.
On Program Completion, with an Application to the Sum and Product Puzzle
Authors: LIFSCHITZ VLADIMIR 
Published: July 2023

AbstractThis paper describes a generalization of Clark’s completion that is applicable to logic programs containing arithmetic operations and produces syntactically simple, natural looking formulas. If a set of first-order axioms is equivalent to the completion of a program, then we may be able to find standard models of these axioms by running an answer set solver. As an example, we apply this “reverse completion” procedure to the Sum and Product Puzzle.
Atypical Melanocytic Matricoma: A Case Report with Molecular Studies
Authors: Feoli Francesco , Stieber Daniel , Bormans Anne , Corsten Marcus 
Published: July 2023

Abstract:
Melanocytic matricoma is a rare benign pilar tumor characterized by matrical differentiation and interspersed dendritic melanocytes. It may show cellular atypia and brisk mitotic activity. Histological characterization of some lesions may be difficult. In addition, because the reported cases are few and have limited follow-up, there is insufficient experience to define outcome-based criteria for malignancy. Some cases of melanocytic matricoma with more prominent atypia have been reported as malignant, but their clinical behavior is uncertain. We present a melanocytic matricoma with interspersed benign dendritic melanocytes, but moderate basaloid atypia, focally brisk mitotic activity, and atypical mitoses. Despite the apparently good delimitation of this tumor, higher magnification revealed a slightly irregular border. However, overt malignant features such as necrosis, frank asymmetry, deep infiltration, and ulceration were not present. This tumor showed a complex aberrant genomic profile with multiple whole chromosomes or chromosomal arms, losses, and duplications. The tumor mutational burden was high. A loss-of-function alteration in CDKN2A and a loss-of-function mutation in TP53 were also present. This unexpected molecular profile contrasts with the relatively bland histology of the tumor and is in line with the difficulties in microscopic differential diagnosis between melanocytic matricoma and an indolent malignant pilomatrical tumor. We suggest that molecular studies and longer follow-up periods may help to further understand and more precisely categorize borderline pilomatrical tumors with melanocytic hyperplasia.
Motives and strategies of women pursuing careers in IT and HR managerial positions
Authors: Sołek-Borowska Celina , Tabor-Błażewicz Joanna 
Published: July 2023

Purpose Despite more than 50 years of research into gender and work, the impact of women occupying managerial positions persists to be under-represented in mainstream human resource management (HRM) literature. The purpose of this article is to identify and explore the perceptions of women who decided to choose their career path either in IT or HR positions to explore their motivation, career strategies and success factors.Design/methodology/approach Twenty semi-structured interviews were conducted with women occupying either IT or HR managerial positions. The study included two datasets: (1) women representing managerial positions in IT and (2) women representing managerial positions in HR.Findings Women holding HR managerial positions took action to achieve the intended position in their dream industry since their studies. On the contrary, the choice of the IT industry was one undertaken by candidates with no previous IT experience. Because the IT sector is dominated by men, women in these positions still had to prove their competences.Research limitations/implications The research showed that women cannot be ignored in the science, technology, engineering and mathematics (STEM) industry, and they prove a valuable resource for managerial positions in IT or HR departments in many sectors.Originality/value The research underpinned a new boundaryless career model for both HR and IT positions.
Managing urban infrastructure assets in the digital era: challenges of municipal digital transformation
Authors: Lafioune Nawel , Poirier Erik Andrew , St-Jacques Michèle 
Published: July 2023

Purpose The purpose of this study is to frame digital transformation (DT) within municipalities to improve the life cycles of urban infrastructure.Design/methodology/approach The study provides the results from a systematic review of the literature on concepts of DT and its implications for municipalities, barriers and challenges to DT, as well existing DT frameworks for municipalities and their built assets. This literature review leads to the development of a DT framework to help cities conduct a planned and federated DT beforehand. Then, workshops are conducted with two major Canadian municipalities.Findings The results of these studies point to the need for a dedicated DT framework for municipalities because of their particular context and their role and proximity to citizens. The theoretical framework develops 22 elements, which are divided among 6 categories. Through its application, the framework helps to identify and target the predominant issues hindering the DT of municipalities, specifically “legacy practices” and “data management.”Research limitations/implications Limitations include limited experimental conditions and small sample size. Further work is needed to validate the framework. Other approaches are advocated to complement the data collection and analysis to generate more convincing results.Practical implications The theoretical framework was validated through two case studies on two large Canadian municipalities.Social implications Municipalities maximize the value they provide to citizens and to be at the forefront of resilience and sustainability concerns. The use of technology, digital processes and initiatives helps cities to improve planning, optimize works and provide better services to citizens.Originality/value The framework is original in that it specifically aligns assets management with DT in a municipal context.
Development of clinical criteria for the evaluation of indirect restorations
Authors: Montenegro Silvana Pizzini , Ramidan Juliana Cabral , Michelon Marcela Mendes Medeiros , Breves Ricardo Caldeira , Fonseca Giuliana Vasconcelos de Souza , Teixeira Mayla Kezy Silva , Lourenço Eduardo José Veras , Telles Daniel de Moraes 
Published: July 2023

AbstractObjectiveTo propose the development and validation of criteria for evaluating the clinical performance of indirect restorations, considering the variables related to the operator, material, and/or patient.Materials and MethodsThe experimental design of this study was divided into three stages. Stage 1: development of the new criteria items by specialists in Prosthodontics. Step 2: creation of the criteria, named UERJ criteria, with the description of the parameters that indicate the quality of the restoration, the possible associated complications, and a detailed description of each classification. As well as the development of a form of variables. Step 3: validation of the UERJ criteria.ResultsCohen's Kappa statistic registered for both intra‐ and inter‐examiner agreements a coefficient >0.91 with a p‐value <0.0001. The validity of the UERJ criteria was evaluated by tests of sensitivity (0.96) and specificity (0.91) and had a satisfactory accuracy (92.7%), a positive (10.99), and negative (0.05) likelihood ratio and high values predictive variables, with positive (PPV) 0.84 (high specificity) and negative (VPN) 0.98 (high sensitivity), with a confidence interval of 95%.ConclusionThe UERJ criteria is a valid instrument for evaluating the clinical performance of indirect restorations.Clinical SignificanceThe UERJ criteria, developed exclusively for the analysis of indirect restorations, elucidates the details necessary to identify the causes of failures and complications of these restorations.
On free fall of fermions and antifermions
Authors: Emelyanov Viacheslav A. 
Published: July 2023

AbstractWe propose a model describing spin-half quantum particles in curved spacetime in the framework of quantum field theory. Our model is based on embodying Einstein’s equivalence principle and general covariance in the definition of quantum-particle states. With this model at hand, we compute several observables which characterise spin-half quantum particles in a gravitational field. In particular, we find that spin precesses in a normal Fermi frame, even in the absence of torsion. The effect appears to be complementary to free-fall non-universality we have recently reported about for spinless quantum particles. Furthermore, we find that quantum-particle gravitational-potential energy is insensitive to wave-packet spreading in the Earth’s gravitational field, that is responsible for the non-universality of free fall in quantum theory. This theoretical result provides another channel for the experimental study of our quantum-particle model by using gravitational spectrometers. Finally, we also find that (elementary) fermions and antifermions are indistinguishable in gravity.
Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption
Authors: Zarkada Georgia , Chen Xun , Zhou Xuetong , Lange Martin , Zeng Lei , Lv Wenyu , Zhang Xuan , Li Yunhua , Zhou Weibin , Liu Keli , Chen Dongying , Ricard Nicolas , Liao James , Kim Young-Bum , Benedito Rui , Claesson-Welsh Lena , Alitalo Kari , Simons Michael , Ju Rong , Li Xuri , Eichmann Anne , Zhang Feng 
Published: July 2023

Background:
Lymphatic vessels are responsible for tissue drainage, and their malfunction is associated with chronic diseases. Lymph uptake occurs via specialized open cell-cell junctions between capillary lymphatic endothelial cells (LECs), whereas closed junctions in collecting LECs prevent lymph leakage. LEC junctions are known to dynamically remodel in development and disease, but how lymphatic permeability is regulated remains poorly understood.

Methods:
We used various genetically engineered mouse models in combination with cellular, biochemical, and molecular biology approaches to elucidate the signaling pathways regulating junction morphology and function in lymphatic capillaries.

Results:
By studying the permeability of intestinal lacteal capillaries to lipoprotein particles known as chylomicrons, we show that ROCK (Rho-associated kinase)-dependent cytoskeletal contractility is a fundamental mechanism of LEC permeability regulation. We show that chylomicron-derived lipids trigger neonatal lacteal junction opening via ROCK-dependent contraction of junction-anchored stress fibers. LEC-specific ROCK deletion abolished junction opening and plasma lipid uptake. Chylomicrons additionally inhibited VEGF (vascular endothelial growth factor)-A signaling. We show that VEGF-A antagonizes LEC junction opening via VEGFR (VEGF receptor) 2 and VEGFR3-dependent PI3K (phosphatidylinositol 3-kinase)/AKT (protein kinase B) activation of the small GTPase RAC1 (Rac family small GTPase 1), thereby restricting RhoA (Ras homolog family member A)/ROCK–mediated cytoskeleton contraction.

Conclusions:
Our results reveal that antagonistic inputs into ROCK-dependent cytoskeleton contractions regulate the interconversion of lymphatic junctions in the intestine and in other tissues, providing a tunable mechanism to control the lymphatic barrier.
Combining perineural invasion with staging improve the prognostic accuracy in colorectal cancer: a retrospective cohort study
Authors: Zhang Bin , Lin Yanyun , Wang Chao , Chen Zexian , Huang Tianze , Chen Hao , Wang Guannan , Lan Ping , He Xiaowen , He Xiaosheng 
Published: July 2023

Abstract
Background
Current guidelines only propose the importance of perineural invasion(PNI) on prognosis in stage II colon cancer. However, the prognostic value of PNI in other stages of colorectal cancer (CRC) is ambiguous.

Methods
This single-center retrospective cohort study included 3485 CRC patients who underwent primary colorectal resection between January 2013 and December 2016 at the Sixth Affiliated Hospital of Sun Yat-sen University. Associations of PNI with overall survival (OS) and disease-free survival (DFS) were evaluated using multivariable Cox proportional hazards regression models. In addition, interaction analyses were performed to explore the prognostic effects of PNI in different clinical subgroups.

Results
After median follow-up of 61.9 months, we found PNI was associated with poorer OS (adjusted hazard ratio [aHR], 1.290; 95% CI, 1.087–1.531) and DFS (aHR, 1.397; 95% CI, 1.207–1.617), irrespective of tumor stage. Interestingly, the weight of PNI was found second only to incomplete resection in the nomogram for risk factors of OS and DFS in stage II CRC patients. Moreover, OS and DFS were insignificantly different between stage II patients with PNI and stage III patients (both P > 0.05). PNI was found to be an independent prognostic factor of DFS in stage III CRC (aHR: 1.514; 95% CI, 1.211–1.892) as well. Finally, the adverse effect of PNI on OS was more significant in female, early-onset, and diabetes-negative patients than in their counterparts (interaction P = 0.0213, 0.0280, and 0.0186, respectively).

Conclusion
PNI was an important prognostic factor in CRC, more than in stage II. The survival of patients with stage II combined with perineural invasion is similar with those with stage III. PNI in stage III CRC also suggests a worse survival.
Diagnostic Accuracy of Primary Care Clinicians Across a Statewide System of Autism Evaluation
Authors: McNally Keehn Rebecca , Swigonski Nancy , Enneking Brett , Ryan Tybytha , Monahan Patrick , Martin Ann Marie , Hamrick Lisa , Kadlaskar Girija , Paxton Angela , Ciccarelli Mary , Keehn Brandon 
Published: July 2023

OBJECTIVES
To evaluate the diagnostic accuracy of the Early Autism Evaluation (EAE) Hub system, a statewide network that provides specialized training and collaborative support to community primary care providers in the diagnosis of young children at risk for autism spectrum disorder (ASD).

METHODS
EAE Hub clinicians referred children, aged 14 to 48 months, to this prospective diagnostic study for blinded follow-up expert evaluation including assessment of developmental level, adaptive behavior, and ASD symptom severity. The primary outcome was agreement on categorical ASD diagnosis between EAE Hub clinician (index diagnosis) and ASD expert (reference standard).

RESULTS
Among 126 children (mean age: 2.6 years; 77% male; 14% Latinx; 66% non-Latinx white), 82% (n = 103) had consistent ASD outcomes between the index and reference evaluation. Sensitivity was 81.5%, specificity was 82.4%, positive predictive value was 92.6%, and negative predictive value was 62.2%. There was no difference in accuracy by EAE Hub clinician or site. Across measures of development, there were significant differences between true positive and false negative (FN) cases (all Ps &lt; .001; Cohen’s d = 1.1–1.4), with true positive cases evidencing greater impairment.

CONCLUSIONS
Community-based primary care clinicians who receive specialty training can make accurate ASD diagnoses in most cases. Diagnostic disagreements were predominately FN cases in which EAE Hub clinicians had difficulty differentiating ASD and global developmental delay. FN cases were associated with a differential diagnostic and phenotypic profile. This research has significant implications for the development of future population health solutions that address ASD diagnostic delays.
Viruela símica en un paciente con VIH: reporte de caso
Authors: Franco Lacato Alex Omar , Chaparro Mérida Nataniel Aldo , Moreno Samper Dayany , Orellana Padilla Delmira Selmira , Vides Melendres Daniel , Auza Santivañez Jhossmar Cristians 
Published: July 2023

La viruela símica es una enfermedad zoonótica endémica en algunas zonas de África; desde mayo del 2022 se confirmaron múltiples reportes de viruela símica (VS) en países no endémicos. Se presenta el caso de un paciente con antecedente de VIH con exantemas en diversas regiones del cuerpo, con mayor concentración en la región glútea, asociado a adenopatías cervicales y proctitis infecciosa. Se procedió a la toma de la muestra de las lesiones dermatológicas para el estudio molecular de reacción en cadena de la polimerasa en tiempo real (RT-PCR), que confirmó el diagnóstico de VS. La infección por Treponemapallidum y Neisseria gonorrhoeae se identificó mediante serología y cultivo de secreción anal, respectivamente. Se aplicó tratamiento con antibióticos específicos para gonorrea y sífilis, y la VS respondió favorablemente a la terapia sintomática e inmunomoduladora.
Design and laying out of roads and paths in Greece for better management and development of the forest area
Authors: Liampas Sarantis-Angelos , DROSOS VASILEIOS 
Published: July 2023

The forest covers everyday many human needs (e.g. recreation, walking, hiking, mountaineering, training, sports, etc.). These activities are achieved through the use of paths, which are now well developed and have taken the form of a network. During the past they constituted shaped ways by pedestrians and animals in order to join places that have for man any particular interest.
Today, with technology development, in their mapping and surveying was given to them great importance, because they serve as mentioned above many activities and at the same time constitute an ecological form of road, friendlier to the environment than other classic routes.
In consequence, depending on the regions we want to approach, potential users, the length, the degree of difficulty and their shape, we distinguish the paths in various categories (paths of big corridors, mountaineering paths hiking trails, peripatetic paths, educational paths and in combinations of paths). Greece except from the national trails contains also parts of two international paths (E4, E6).
The design and laying out of paths is judged essential because it constitutes important tool of sustainable management. In order to laying out of the paths and the production of maps can be used several devices and instruments such as the Global Positioning System (GPS) and the electronic compass - finder (TruePulse 360° B).
These devices provide us with enough information about the terrain and they contribute to the creation of topographical activities in order to develop the area as it appears in this paper. The study area is a typical semi mountainous area in the Macedonia region.
The results of the measurements are presented in GIS, where the final shape of the path is appeared, and the points of measurement are given in tables. The mapping can be extended and the results of the surveying can be included in a printed or electronic map data in order to be used by stakeholders.
Observation of Single-Molecule Raman Spectroscopy Enabled by Synergic Electromagnetic and Chemical Enhancement
Authors: Li Zhi-Yuan , Yang Haiyao , Hong Lihong , Mo Haoran 
Published: July 2023

Abstract
Raman spectroscopy is a powerful tool to detect, analyze and identify molecules. It has been a long-history pursuit to push the detection limit of Raman spectroscopy down to the fundamental single-molecule (SM) level. Due to the tiny cross section of intrinsic Raman scattering of molecule, some enhancement mechanisms of light-matter interaction must be implemented to levitate the Raman scattering intensity by a huge number of ~ 14–15 orders of magnitude, to the level comparable with the molecule fluorescence intensity. In this work we report unambiguous observation of single-molecule Raman spectroscopy via synergic action of electromagnetic and chemical enhancement for rhodamine B (RhB) molecule absorbed within the plasmonic nanogap formed by gold nanoparticle sitting on the two-dimensional (2D) monolayer WS2 and 2 nm SiO2 coated gold thin film. Raman spectroscopy down to an extremely dilute value of 10− 18 mol/L can still be clearly visible, and the statistical enhancement factor could reach 16 orders of magnitude compared with the reference detection sample of silicon plate with a detection limit of 10− 2 mol/L. The electromagnetic enhancement comes from local surface plasmon resonance induced at the nanogap, which could reach ~ 10–11 orders of magnitude, while the chemical enhancement comes from monolayer WS2 2D material, which could reach 4–5 orders of magnitudes. The synergic implementation and action of these two prestigious Raman scattering enhancement mechanisms in this specially designed 2D material-plasmon nanogap composite nanoscale system enables unambiguous experimental observation of single-molecule Raman spectroscopy of RhB molecule. This route of Raman enhancement devices could open up a new frontier of single molecule science, allowing detection, identification, and monitor of single molecules and their spatial-temporal evolution under various internal and external stimuli.