bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice
Authors: Choi Mi Jin , Yu Hana , Kim Jea Il , Seo Hee , Kim Ju Gyeong , Kim Seul-Ki , Lee Hak Sung , Cheon Hyae Gyeong 
Published: February 2023

Abstract
Purpose
Previous reports showed that some probiotics provide beneficial effects on various diseases including metabolic disorders. This study aimed to investigate the anti-obesity effects of Lactiplantibacillus (L.) plantarum SKO-001 (SKO-001), a probiotic strain newly isolated from Angelica gigas.

Methods
C57BL/6J mice were fed with high-fat diet (HFD, 60% fat) for four weeks, and then different doses of SKO-001 (n = 10 each group) were orally given for 12 weeks. Following treatment, body weight, fat weight, serum parameters and adipose and liver tissues were analyzed.

Results
SKO-001 (2 × 1010 CFU/day, per os) reduced body weight gain after 10th week of administration, accompanied by a reduction in body fat mass of mice. In the SKO-001-fed group, increased serum adiponectin, decreased leptin, insulin, total cholesterol, low-density lipoprotein cholesterol, free fatty acids, and triglyceride levels were observed. Hematoxylin and eosin staining of various fat depots showed that increased adipocyte size caused by HFD intake was markedly reduced and correlated with reduced mRNA levels of lipogenesis genes, including sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and CCAAT/enhancer binding protein alpha, and increased uncoupling protein 1 levels. Similarly, SKO-001 reduced lipid accumulation, decreased the mRNA levels of lipogenic genes, and reduced α-smooth muscle actin and collagen type 1 alpha 1 levels in the liver.

Conclusions
SKO-001 ameliorates obesity and related metabolic abnormalities in adipose and liver tissues, possibly via the regulation of lipid metabolism. Based on the results of the present study, SKO-001 may be applicable as an anti-obesity therapeutic or functional food.
Monogenetic volcanism in subduction settings: comparative statistical study of the Sierra Chichinautzin and Los Tuxtlas Volcanic Fields in Mexico
Authors: Sieron Katrin , Guilbaud Marie-Noëlle , Zarazúa-Carbajal María Cristina , Juárez Cerrillo Sergio Francisco 
Published: February 2023

Abstract
Monogenetic fields present significant diversity, yet this diversity has not been fully quantified, and its origin remains elusive. We studied two large subduction-related fields in Mexico, the Sierra Chichinautzin and Los Tuxtlas, that have distinct crustal stress regime and structures, magma compositions, vent types, and climatic conditions. Using recently available 5-m resolution topographical data, we located all the eruptive centers, studied their spatial distribution and analyzed scoria cone shapes in detail, calculating morphometric parameters for the best preserved. We then applied a set of statistical tools to analyze and compare the patterns of vent distribution, vent alignment, and diversity in cone shapes in these two fields. We observe that, despite their distinct setting, the two fields are similar in terms of vent distribution and cone morphology, which shows that this type of data cannot be used alone to infer the tectonic, magmatic, and climatic context of monogenetic fields. It also confirms previous results that the diversity in cone shapes (slope, height-to-diameter ratio) reflects processes that are common to all cones (e.g., ballistic emplacement followed by scoria avalanching on slopes), and hence do not vary significantly (at field-scale) with external parameters. Differences in the crustal stress regime had no apparent impact on vent distribution as the dikes followed active faults, irrespective of their motion. Climatic differences did not affect the shape variety of the studied cones probably because of their young ages (< 50,000 years old) and their location in a vegetated environment. The fields nevertheless differ in size and vent density, as well as scoria cone shape complexity and volume, which can be attributed to differences in the geometry of the magma source for its impact on the closeness of the dikes feeding the activity. Differences in the relative proportion of small cones in both fields are likely due to factors impacting eruptive style such as magma-water interaction, magma composition, and/or fissure lengths.
Modality preferences for health behaviour interventions for post-treatment cancer survivors: a theoretical investigation
Authors: Leske Morgan , Koczwara Bogda , Morris Julia , Beatty Lisa 
Published: February 2023

Abstract
Purposes
User preferences for how programs are delivered are an important consideration when developing healthy living interventions. The aim of this study was to investigate (a) if cancer survivors prefer telephone or internet delivery for a healthy living intervention and (b) what factors were associated with delivery preference.

Methods
Australian cancer survivors (18 + years) were invited to complete an online or hardcopy cross-sectional survey measuring social and clinical demographic factors and validated measures of self-efficacy, health literacy, and social support.

Results
Of the 168 respondents, the majority were female (n = 147, 92%) and breast cancer survivors (n = 122, 80%) and preferred internet delivery (n = 109, 65%). Participants who preferred internet delivery had a longer time since diagnosis (M = 9.85 years, SD = 8.20) compared to those who preferred telephone (M = 6.80 years, SD = 5.54), p = .03. However, logistic regression analyses demonstrated that no other variables (age, gender, socio-economic status, BMI, education, self-efficacy, health literacy, nor social support) had a direct association on delivery preference.

Conclusions
Cancer survivors appear to prefer internet delivery to telephone, particularly for those further along the survivorship trajectory. Future intervention development should therefore consider the internet modality for delivering accessible health interventions and offer the program to long-term cancer survivors. Whether these findings are replicable in the current post-pandemic phase is an important avenue for future research.
The effects of platelet-rich plasma injections in different stages of knee osteoarthritis
Authors: Annaniemi Juho A , Pere Jüri , Giordano Salvatore 
Published: February 2023

Abstract
Purpose
Platelet-rich plasma (PRP) injections are challenging the current treatment options for knee osteoarthritis (KOA). Targeting the treatment to optimal stage of the symptomatic KOA may be crucial in the success and failure of treatment. The aim of this study is to compare the outcomes of PRP injections at different stages of KOA in order to determine the optimal stage of the KOA for PRP injection treatments.

Methods
A total of 89 consecutive patients with symptomatic KOA Kellgren–Lawrence grade 1 to 3 (Group A grade 1, group B grade 2 and group C grade 3) were given three intra-articular injections of PRP with 2 weeks interval between injections. Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Range of Motion were measured before injection, at 15 days, 6 months, 12 months and, at last follow-up. Intergroup outcomes were compared.

Results
The comparison of groups A and C showed that WOMAC scores were significantly higher in group C at 15 days [p = 0.047] and at last follow-up [p = 0.008] than in group A, as well as VAS scores at 6 months [p = 0.031] and at last follow-up [p = 0.008]. The overall WOMAC and VAS scores showed decrease in all the groups in minimum follow-up of 14 months. The other comparisons did not show significant differences in outcomes.

Conclusion
All the groups showed decrease in WOMAC and VAS, but patients with mild KOA benefit significantly more from the treatments than patients with more severe KOA.
Aktuelle interdisziplinäre Behandlung von Knochenmetastasen
Authors: Guckenberger Matthias , Guninski Ricarda Stella , Hüllner Martin , Kobe Adrian , Schaser Klaus‑D. , Wicki Andreas 
Published: February 2023

ZusammenfassungEine Vielzahl an Krebspatienten entwickelt im Verlauf Knochenmetastasen. Die daraus folgenden Symptome wie Schmerzen, Funktionsverlust sowie neurologische Symptome können rasch zu einem onkologischen oder auch chirurgischen Notfall werden, es besteht in vielen Fällen rascher Handlungsbedarf. Ziel dieser Arbeit ist die Darstellung der aktuellen, evidenzbasierten interdisziplinären Behandlung von Knochenmetastasen. Grundsätzlich ist die interdisziplinäre Zusammenarbeit und die Abstimmung aller Disziplinen der Goldstandard zur optimalen Behandlung ossärer Metastasen.
Creating a Medical Imaging Workflow Based on FHIR, DICOMweb, and SVG
Authors: Tang Shih-Tsang , Tjia Victoria , Noga Thalia , Febri Jeshika , Lien Chung-Yueh , Chu Woei-Chyn , Chen Chin-Yu , Hsiao Chia-Hung 
Published: February 2023

AbstractThis paper proposes a web-based workflow scheme for the organization of medical images using FHIR and DICOM servers equipped with standard RESTful APIs. In our integrated workflow, the client systems (including order placer, scheduler, imaging modality, viewer, and report creator) use standard FHIR and DICOMweb APIs. The proposed scheme also facilitates the creation of reports formatted as standard FHIR resources. This paper leverages W3C Scalable Vector Graphics (SVG) to record the image graphic annotations, and encapsulates the SVG image annotation in FHIR observation. FHIR DiagnosticReports and Observations are used to encapsulate reports, findings, and annotations, thereby facilitating the implementation and integration of the scheme within existing structures. The proposed scheme also provides the potential to make it possible to convert results of Computer Aided Detection/Diagnosis from medical images into FHIR DiagnosticReports and Observations to be stored on a FHIR server. The resulting web-based solution uses FHIR XML and/or JSON data to record and exchange information related to imaging workflow. It can also be used to store imaging reports, findings, and annotations linked to the images using the DICOM WADO-RS protocol. As a result, it is possible to integrate all information that is created in medical imaging workflow. Finally, the proposed scheme is easily integrated with other FHIR systems.
Egalitarian judgment aggregation
Authors: Botan Sirin , de Haan Ronald , Slavkovik Marija , Terzopoulou Zoi 
Published: February 2023

AbstractEgalitarian considerations play a central role in many areas of social choice theory. Applications of egalitarian principles range from ensuring everyone gets an equal share of a cake when deciding how to divide it, to guaranteeing balance with respect to gender or ethnicity in committee elections. Yet, the egalitarian approach has received little attention in judgment aggregation—a powerful framework for aggregating logically interconnected issues. We make the first steps towards filling that gap. We introduce axioms capturing two classical interpretations of egalitarianism in judgment aggregation and situate these within the context of existing axioms in the pertinent framework of belief merging. We then explore the relationship between these axioms and several notions of strategyproofness from social choice theory at large. Finally, a novel egalitarian judgment aggregation rule stems from our analysis; we present complexity results concerning both outcome determination and strategic manipulation for that rule.
Responsibility Under Uncertainty: Which Climate Decisions Matter Most?
Authors: Botta Nicola , Brede Nuria , Crucifix Michel , Ionescu Cezar , Jansson Patrik , Li Zheng , Martínez Marina , Richter Tim 
Published: February 2023

AbstractWe propose a new method for estimating how much decisions under monadic uncertainty matter. The method is generic and suitable for measuring responsibility in finite horizon sequential decision processes. It fulfills “fairness” requirements and three natural conditions for responsibility measures: agency, avoidance and causal relevance. We apply the method to study how much decisions matter in a stylized greenhouse gas emissions process in which a decision maker repeatedly faces two options: start a “green” transition to a decarbonized society or further delay such a transition. We account for the fact that climate decisions are rarely implemented with certainty and that their consequences on the climate and on the global economy are uncertain. We discover that a “moral” approach towards decision making — doing the right thing even though the probability of success becomes increasingly small — is rational over a wide range of uncertainties.
An empirical model of heat-treated straw bulks’ thermal conductivity based on changes in mass and chemical composition
Authors: Csanády Dániel , Fenyvesi Olivér , Nagy Balázs 
Published: February 2023

AbstractAn empirical model was developed to estimate the thermal conductivity of heat-treated straw bulks based on laboratory experiments. During the measurements, two different types of straw were investigated, barley and wheat. Barley was used to composing our empirical model and define the influencing model parameters, and wheat straw was used for validation. Both straws were heat-treated in a dry oxidative ambient in five temperature steps from 60 to 180 °C. The thermal conductivity was measured at 120 kg m−3 bulk density after every treatment cycle. In addition, we were looking for the most suitable measurement methods to detect changes in material structure related to thermal conductivity in the range of relatively low-temperature treatments. Thermogravimetric measurement was conducted, and the mass loss and elemental composition were measured after every treatment cycle. The measurements showed that the mass percentage ratio of carbon in straw increased, and the mass percentage of oxygen decreased in the investigated temperature range. We identified and separated the following parameters of the model, which can estimate the relative thermal conductivity of heat-treated stem bulks: relative residual mass, relative mass percentage ratio of carbon content and oxygen content. We divided the model into two parts, creating a simpler but worse approximation (the measurements required for this are much easier to perform) and a slightly more complex but better approximation. After the validation, our model achieved good agreement with the relative thermal conductivities calculated by the measured thermal conductivities.
Improving the congruency of satellite-based fertilizer maps with field-operable units using pneumatic spreaders
Authors: Lösch Maximilian , Schmidhalter Urs 
Published: February 2023

AbstractThe dramatically increasing nitrogen fertiliser prices and growing environmental awareness emphasise the need to optimise machine operability to avoid double overlapping of the target dose rate in different field units, including headlands and field bodies, to be more congruent with satellite-based nitrogen prescription maps. However, the map grids frequently do not correspond with farmers’ management practices, specifically machine operability. To this end, this study develops an algorithm that subdivides any given field into operable units by considering pneumatic spreaders based on the actual tramline on the field and placing the operable units along with this. The newly developed algorithm allows ex-ante specification of the required fertiliser amount. It shows how well such techniques can implement an optimised application map supported by the statistical information for each field unit. Uniform fertilizer application can further be compared with variable rate application (VRA) as well as machinery with and without section control, allowing the identification of areas with the greatest deviation and the excess amount of nitrogen applied. A more precise nitrogen application on both homogeneous or heterogeneous field units saves nitrogen and decreases the negative environmental impact.
Monument protection as a limiting factor for large scale vertical greening system implementation to counteract indoor heat stress – a GIS-based analysis for Berlin, Germany
Authors: Roesch Emil J. , Hoffmann Karin A. , Nehls Thomas 
Published: February 2023

AbstractVertical greening systems (VGS), as proven strategy for adaptation to heat stress, are prohibited for monument-protected buildings and façades. To what extent monument protection effectively limits the implementation of VGS in heat stress affected city centers has not been quantified yet. In this study, the ratio of buildings under monument protection was quantified for Berlin, Germany, using a GIS analysis. It was then compared to a map of potential heat stress. This was done for the entire city and the inner-city area on block-scale.Therefore, maps of the Berlin buildings, monuments and blocks were processed. The ratio of buildings under monument protection was calculated for each block of Berlin. To not deform the outcome, urban green areas were cut out of the maps. Inside the 80 km2 city center of Berlin, which is severely affected by heat stress, the range of monument protection prohibiting VGS in the individual blocks ranges from 0 % to 100 ﻿%. However, 25.42 ﻿% of the building façades in the city center and 16.20 ﻿% for whole of Berlin are protected on average and therefore cannot be greened. Compared to other restricting factors, monument protection does not generally hinder large scale implementation of VGS in Berlin. Nonetheless, 102 potentially heat stress exposed blocks inhabited by 48,122 people cannot be greened due to monument protection. This demonstrates that VGS should be discussed as exception from monument protection that can be justified by a predominant public interest. It also points to the need of minimal invasive and mobile greenery technologies, which would enable heritage-protection conform greening.
Multi-country metabolic signature discovery for chicken health classification
Authors: Wolthuis Joanna C. , Magnúsdóttir Stefanía , Stigter Edwin , Tang Yuen Fung , Jans Judith , Gilbert Myrthe , van der Hee Bart , Langhout Pim , Gerrits Walter , Kies Arie , de Ridder Jeroen , van Mil Saskia 
Published: February 2023

Abstract
Introduction
To decrease antibiotic resistance, their use as growth promoters in the agricultural sector has been largely abandoned. This may lead to decreased health due to infectious disease or microbiome changes leading to gut inflammation.

Objectives
We aimed to generate a m/z signature classifying chicken health in blood, and obtain biological insights from the resulting m/z signature.

Methods
We used direct infusion mass-spectrometry to determine a machine-learned metabolomics signature that classifies chicken health from a blood sample. We then challenged the resulting models by investigating the classification capability of the signature on novel data obtained at poultry houses in previously unseen countries using a Leave-One-Country-Out (LOCO) cross-validation strategy. Additionally, we optimised the number of mass/charge (m/z) values required to maximise the classification capability of Random Forest models, by developing a novel ranking system based on combined univariate t-test and fold-change analyses and building models based on this ranking through forward and reverse feature selection.

Results
The multi-country and LOCO models could classify chicken health. Both resulting 25-m/z and 3784-m/z signatures reliably classified chicken health in multiple countries. Through mummichog enrichment analysis on the large m/z signature, we found changes in amino acid metabolism, including branched chain amino acids and polyamines.

Conclusion
We reliably classified chicken health from blood, independent of genetic-, farm-, feed- and country-specific confounding factors. The 25-m/z signature can be used to aid development of a per-metabolite panel. The extended 3784-m/z version can be used to gain a deeper understanding of the metabolic causes and consequences of low chicken health. Together, they may facilitate future treatment, prevention and intervention.
Virtual monochromatic spectral CT imaging in preoperative evaluations for intraductal spread of breast cancer: comparison with conventional CT and MRI
Authors: Matsuura Yuko , Kamitani Takeshi , Sagiyama Koji , Yamasaki Yuzo , Hino Takuya , Kubo Makoto , Ijichi Hideki , Yamamoto Hidetaka , Yabuuchi Hidetake , Ishigami Kousei 
Published: February 2023

Abstract
Purpose
To investigate the efficacy of virtual monochromatic spectral computed tomography imaging (VMI) in the preoperative evaluation for intraductal spread of breast cancer.

Materials and methods
Twenty-four women who underwent spectral CT and were pathologically diagnosed with ductal carcinoma with a ≥ 2-cm noninvasive component were retrospectively enrolled in Group 1. Twenty-two women with 22 lesions pathologically diagnosed with ductal carcinoma in situ or microinvasive carcinoma were enrolled in Group 2. We compared the contrast-to-noise ratios (CNRs) of the lesions on conventional 120-kVp CT images and 40-keV VMIs in Group 1. Two board-certified radiologists measured the maximum diameters of enhancing areas on 120-kVp CT, 40-keV VMI, and MRI in Group 2 and compared with histopathological sizes.

Results
The quantitative assessment of Group 1 revealed that the mean ± SD of the CNRs in the 40-keV images were significantly greater than those in the 120-kVp images (5.5 ± 1.9 vs. 3.6 ± 1.5, p < 0.0001). The quantitative assessment of Group 2 demonstrated that the lesion size observed in the conventional 120-kVp CT images by both readers was significantly underestimated as compared to the histopathological size (p = 0.017, 0.048), whereas both readers identified no significant differences between the lesion size measured on 40-keV VMI and the histopathological data. In a comparison with MRI, 40-keV VMI provided measurement within a 10-mm error range in more lesions as compared to the conventional 120-kVp CT.

Conclusion
VMI improves the evaluation of intraductal spread and is useful for the preoperative evaluations of breast cancer.
New classes of p-adic evolution equations and their applications
Authors: Torresblanca-Badillo Anselmo , Bolaño-Benitez Edwin A. 
Published: February 2023

AbstractIn this article, we study new classes of evolution equations in thep-adic context. We establish rigorously that the fundamental solutions of the homogeneous Cauchy problem, naturally associated to these equations, are transition density functions of some strong Markov processes$${\mathfrak {X}}$$Xwith state space then-dimensionalp-adic unit ball ($${\mathbb {Z}}_{p}^{n}$$Zpn). We introduce a family of operators$$\{T_{t}\}_{t\ge 0}$${Tt}t≥0(obtained explicitly) that determine a Feller semigroup on$$C_{0}({\mathbb {Z}}_{p}^{n})$$C0(Zpn). Also, we study the asymptotic behavior of the survival probability of a strong Markov processes$${\mathfrak {X}}$$Xon a ball$$B_{-m}^{n}\subset {\mathbb {Z}}_{p}^{n}$$B-mn⊂Zpn,$$m\in {\mathbb {N}}$$m∈N. Moreover, we study the inhomogeneous Cauchy problem and we will show that its mild solution is associated with the mentioned above Feller semigroup.