bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying the potential origin of mucin in primary cutaneous mucinoses—A retrospective study and analysis using histopathology and multiplex fluorescence staining
Authors: Steinmann S. , Guillet C. , Cheng P. F. , Levesque M. P. , Dummer R. , Kolm I. , Maul J. T. 
Published: February 2023

AbstractBackgroundPrimary cutaneous mucinoses (PCM) are rare diseases characterized by dermal or follicular mucin deposits.ObjectivesA retrospective study characterizing PCM to compare dermal with follicular mucin to identify its potential origin on a single‐cell level.Material and MethodsPatients diagnosed with PCM between 2010 and 2020 at our department were included in this study. Biopsy specimens were stained using conventional mucin stains (Alcian blue, PAS) and MUC1 immunohistochemical staining. Multiplex fluorescence staining (MFS) was used to investigate which cells were associated with MUC1 expression in select cases.ResultsThirty‐one patients with PCM were included, 14 with follicular mucinosis (FM), 8 with reticular erythematous mucinosis, 2 with scleredema, 6 with pretibial myxedema and one patient with lichen myxedematosus. In all 31 specimens, mucin stained positive for Alcian blue and negative for PAS. In FM, mucin deposition was exclusively found in hair follicles and sebaceous glands. None of the other entities showed mucin deposits in follicular epithelial structures. Using MFS, all cases showed CD4+ and CD8+ T cells, tissue histiocytes, fibroblasts and pan‐cytokeratin+ cells. These cells expressed MUC1 at different intensities. MUC1 expression in tissue histiocytes, fibroblasts, CD4+ and CD8+ T cells, and follicular epithelial cells of FM was significantly higher than the same cell types in the dermal mucinoses (p < 0.001). CD8+ T cells were significantly more involved in expression of MUC1 than all other analysed cell types in FM. This finding was also significant in comparison with dermal mucinoses.ConclusionVarious cell types seem to contribute to mucin production in PCM. Using MFS, we showed that CD8+ T cells seem to be more involved in the production of mucin in FM than in dermal mucinoses, which could indicate that mucin in dermal and follicular epithelial mucinoses have different origins.
Optimal measure preserving derivatives revisited
Authors: Beare Brendan K. 
Published: February 2023

AbstractThis article clarifies the relationship between pricing kernel monotonicity and the existence of opportunities for stochastic arbitrage in a complete and frictionless market of derivative securities written on a market portfolio. The relationship depends on whether the payoff distribution of the market portfolio satisfies a technical condition called adequacy, meaning that it is atomless or is comprised of finitely many equally probable atoms. Under adequacy, pricing kernel nonmonotonicity is equivalent to the existence of a strong form of stochastic arbitrage involving distributional replication of the market portfolio at a lower price. If the adequacy condition is dropped then this equivalence no longer holds, but pricing kernel nonmonotonicity remains equivalent to the existence of a weaker form of stochastic arbitrage involving second‐order stochastic dominance of the market portfolio at a lower price. A generalization of the optimal measure preserving derivative is obtained, which achieves distributional replication at the minimum cost of all second‐order stochastically dominant securities under adequacy.
Tonoplast cytochrome b561 is a transmembrane ascorbate‐dependent monodehydroascorbate reductase: functional characterization of electron currents in plant vacuoles
Authors: Gradogna Antonella , Lagostena Laura , Beltrami Sara , Tosato Edoardo , Picco Cristiana , Scholz‐Starke Joachim , Sparla Francesca , Trost Paolo , Carpaneto Armando 
Published: February 2023

Summary
Ascorbate (Asc) is a major redox buffer of plant cells, whose antioxidant activity depends on the ratio with its one‐electron oxidation product monodehydroascorbate (MDHA). The cytoplasm contains millimolar concentrations of Asc and soluble enzymes that can regenerate Asc from MDHA or fully oxidized dehydroascorbate. Also, vacuoles contain Asc, but no soluble Asc‐regenerating enzymes.
Here, we show that vacuoles isolated from Arabidopsis mesophyll cells contain a tonoplast electron transport system that works as a reversible, Asc‐dependent transmembrane MDHA oxidoreductase. Electron currents were measured by patch‐clamp on isolated vacuoles and found to depend on the availability of Asc (electron donor) and ferricyanide or MDHA (electron acceptors) on opposite sides of the tonoplast.
Electron currents were catalyzed by cytochrome b561 isoform A (CYB561A), a tonoplast redox protein with cytoplasmic and luminal Asc binding sites. The Km for Asc of the luminal (4.5 mM) and cytoplasmic site (51 mM) reflected the physiological Asc concentrations in these compartments. The maximal current amplitude was similar in both directions.
Mutant plants with impaired CYB561A expression showed no detectable trans‐tonoplast electron currents and strong accumulation of leaf anthocyanins under excessive illumination, suggesting a redox‐modulation exerted by CYB561A on the typical anthocyanin response to high‐light stress.
Geology, geochemistry, and genesis of gold mineralization in the Chifumbazi deposit of the Tete Province, Irumide Belt, Mozambique
Authors: Cossa Euclesia P. F. , Agangi Andrea , Takahashi Ryohei , Manalo Pearlyn , Imai Akira , Manjate Vicente 
Published: February 2023

AbstractThe Chifumbazi gold deposit is located in the Chifunde District, Tete Province, northwestern Mozambique. The geology of the study area is composed of the Proterozoic Mualadzi Group comprising ultramafic metavolcanic rocks, quartzite, biotite‐schist, Macanda Mafic Metavolcanics, conglomerate, and granitoid of the Furancungo Suite. The geological characteristics and metallogenesis of gold mineralization in the Tete Province are poorly understood. This study describes the gold mineralization and associated hydrothermal alteration in the Chifumbazi deposit on the basis of petrography, whole‐rock geochemistry, mineral chemistry, fluid inclusion and sulfur isotope analyses. The mineralization in the Chifumbazi deposit includes auriferous quartz, calcite, dolomite and ankerite quartz‐chlorite, and chlorite‐pyrite veins and veinlets as well as sulfide dissemination hosted by altered meta‐granodiorite along shear zones and fracture zones. On a larger scale, the mineralized veins and veinlets occur along a discordant fracture system within a Pan‐African shear zone. The meta‐granodiorite host‐rock of the mineralization consists mainly of plagioclase, biotite, actinolite, and quartz, and alteration minerals calcite, dolomite, sericite, and chlorite. The meta‐granodiorite is enriched in LREE compared to HREE and shows negative Eu anomalies. The mineralization in the Chifumbazi deposit formed through three hypogene mineralization stages (Stages I–III) and one supergene stage (Stage IV). Stage I comprises quartz, calcite, dolomite, ankerite, pyrite, chalcopyrite, pyrrhotite and galena. Stage II comprises quartz, pyrrhotite, pyrite, chalcopyrite and native gold. Stage III comprises chlorite and pyrite; and Stage IV comprises secondary minerals goethite, bornite and covellite. Bulk chemical analysis of ores detected gold contents up to 5 ppm for a quartz vein of Stage II, where visible native gold is present in pyrite. The δ34SCDT values of pyrite and chalcopyrite of the Stages I–III range from +0.9 to +2.4 ‰. On the basis of the geological setting, mineralogy, and sulfur isotope signatures, the Chifumbazi deposit can be classified as orogenic.
Insights into the systematics of Alluaudinella and allied Aethiopomyia and Ochromusca (Muscidae, Diptera)
Authors: Walczak Kinga , Pape Thomas , Ekanem Mfon , Szpila Krzysztof , Grzywacz Andrzej 
Published: February 2023

AbstractThe muscid genera Alluaudinella Giglio‐Tos, 1895, Aethiopomyia Malloch, 1921 and Ochromusca Malloch, 1927 form a monophyletic group supported by immature and adult morphology and a highly specialised snail‐feeding strategy of immature stages. In contrast to the undoubted monophyly of the Alluaudinella‐Aethiopomyia‐Ochromusca clade, previous studies have provided contradictory hypotheses of the subfamiliar position within the Muscidae, and these three genera have been placed in the subfamily Muscinae, Dichaetomyiinae, Phaoniinae and Reinwardtiinae. The systematic position of Alluaudinella, as a representative of Alluaudinella, Aethiopomyia and Ochromusca group, is revised by means of larval morphology, biology and molecular data. Light microscopy (LM), confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM) are used to study the egg and all larval instars of Alluaudinella flavicornis (Macquart, 1855) and a multilocus Sanger sequencing (mS‐seq) approach to examine position within Muscidae. Results are inconsistent with the traditional, morphology‐based concept of the Alluaudinella‐Aethiopomyia‐Ochromusca clade as closely related to Dichaetomyia Malloch, 1921, and the phylogenetic analysis revealed no support for inclusion within subfamily Phaoniinae. Larval morphology in Alluaudinella differs significantly from that of Dichaetomyia (and other Phaoniinae), but resembles that of genera nested in Reinwardtiinae. Based on molecular data and larval morphology a transfer of Alluaudinella, Aethiopomyia and Ochromusca to the subfamily Reinwardtiinae is proposed.
Voluntary torque production is unaffected by changes in local thermal sensation during normothermia and hyperthermia
Authors: Gordon Ralph Joseph Frederick Hills , Tillin Neale Anthony , Diss Ceri Elen , Tyler Christopher James 
Published: February 2023

AbstractThis study investigated altered local head and neck thermal sensation on maximal and rapid torque production during voluntary contractions. Nine participants completed four visits in two environmental conditions: at rectal temperatures ∼39.5°C in hot (HOT; ∼50°C, ∼39% relative humidity) and ∼37°C in thermoneutral (NEU; ∼22°C, ∼46% relative humidity) conditions. Local thermal sensation was manipulated by heating in thermoneutral conditions and cooling in hot conditions. Evoked twitches and octets were delivered at rest. Maximum voluntary torque (MVT), normalised surface electromyography (EMG) and voluntary activation (VA) were assessed during brief maximal isometric voluntary contractions of the knee extensors. Rate of torque development (RTD) and EMG were measured during rapid voluntary contractions. MVT (P = 0.463) and RTD (P = 0.061) were similar between environmental conditions despite reduced VA (−6%; P = 0.047) and EMG at MVT (−31%; P = 0.019). EMG in the rapid voluntary contractions was also lower in HOT versus NEU during the initial 100 ms (−24%; P = 0.035) and 150 ms (−26%; P = 0.035). Evoked twitch (+70%; P < 0.001) and octet (+27%; P < 0.001) RTD during the initial 50 ms were greater in the HOT compared to NEU conditions, in addition to a faster relaxation rate of the muscle (−33%; P < 0.001). In conclusion, hyperthermia reduced neural drive without affecting voluntary torque, likely due to the compensatory effects of improved intrinsic contractile function and faster contraction and relaxation rates of the knee extensors. Changes in local thermal perception of the head and neck whilst hyperthermic or normothermic did not affect voluntary torque.
Discovery of Holocene ooid shoals in a siliciclastic delta, De Grey River, North West Shelf, Australia
Authors: Lebrec Ulysse , Lang Simon C. , Paumard Victorien , O’Leary Michael J. , Yokoyama Yusuke , Hacker Jorg , Webster Jody 
Published: February 2023

AbstractOnshore and offshore site investigations along the dryland tide-dominated De Grey River delta (northwestern Australia) led to the unexpected discovery of the largest yet-known marine ooid shoals in the Indo-Pacific region. Ooids exhibit up to 60 tangential aragonitic laminae that were formed around fluvial sediment grains during the late Holocene. Covering an area &gt;1250 km2, their spatial extent rivals in size individual ooid shoals from the Bahamas. Shoals appear to be spatially linked with the De Grey River, suggesting that fluvial outputs, combined with a macrotidal range, facilitated the precipitation of the ooids. Following their formation, ooids were reworked through tidal and wave processes along the delta. As a result, the delta sedimentary features, including beach ridges, mouth bars, and distributary channels, are composed of ooids.This discovery broadens the range of depositional and climatic environments in which ooids can form and demonstrates that fluvial runoff may not inhibit aragonite precipitation. Such a configuration also provides a unique analogue for ancient ooids found in association with siliciclastic grains and further indicates that the interpretation of typical siliciclastic geomorphologies from geophysical data does not preclude the presence of carbonate grains.
A Comparison of the Outcomes of Open Trigger Release versus Ultrasound-Guided Modified Small Needle-Knife Percutaneous Release for Treatment of Trigger Digits
Authors: LAN Xiaoyong , XIAO Lei , CHEN Baihua , XIONG Yipin , ZOU Lingfeng , LUO Jun 
Published: February 2023

Background: The aim of this randomised prospective study is to compare the outcomes of traditional open trigger digit release versus ultrasound-guided modified small needle-knife (SNK) percutaneous release in the treatment of trigger digits. Methods: Patients with grade 2 and above trigger digits were enrolled into the study and randomly assigned to traditional open surgery (OS) or ultrasound-guided modified SNK percutaneous release group. The patients were followed up for 7, 30 and 180 days after treatment and data with regard to visual analogue scale (VAS) score and Quinnell grading (QG) was collected and compared between the two groups. Results: A total of 72 patients were enrolled in the study with 30 in the OS group and 42 in the SNK group. VAS scores and QG of the two groups significantly decreased at 7 days and 30 days after treatment compared to before treatment, but there was no significant difference between the two groups. There was also no differences between the two groups at 180 days and between the values at 30 days and 180 days. Conclusions: The outcomes of ultrasound-guided SNK percutaneous release is similar to traditional OS. Level of Evidence: Level II (Therapeutic)
Treatment of Multiple Finger Laceration Caused by Green Onion Cutting Machines in South Korea
Authors: KIM Dong Hee , KONG Byeong Seon , JANG Hyo Seok , KWAK Sang Ho , PARK Tae Hyeon , LEE Sang Hyun 
Published: February 2023

Background: Finger injuries caused by green onion cutting machines in Korean kitchens have unique characteristics of an incomplete amputation in which multiple parallel soft tissues and blood vessels are injured in the same form. In this study, we aimed to describe unique finger injuries and to report the treatment outcomes and experiences of performing possible soft tissue reconstructions. Methods: This case series study included 65 patients (82 fingers) from December 2011 to December 2015. The mean age was 50.5 years. We retrospectively classified the presence of fractures and the degree of damage in patients. The injured area involvement level was categorised as distal, middle or proximal. The direction was categorised as sagittal, coronal, oblique or transverse. The treatment results were compared according to the amputation direction and injury area. Results: Of the 65 patients, 35 had a partial finger necrosis and needed additional surgeries. Finger reconstructions were performed through stump revision or local or free flap use. The survival rate was significantly lower in patients with fractures. As for the injury area, distal involvement led to 17 out of 57 patients displaying necrosis and all 5 patients showing the same in proximal involvement. Conclusions: Unique finger injuries caused by green onion cutting machines can easily be treated with simple sutures. Then prognosis is affected by the extent of injury and the presence of fractures. Reconstruction is necessary for finger necrosis owing to extensive blood vessel damage and limitations when making this selection. Level of Evidence: Level IV (Therapeutic)
Osteonecrosis of Trapezium Occurring in Patient with History of Recurrent Carpometacarpal Corticosteroid Injection
Authors: PIEN Irene , MUDGAL Chaitanya S. 
Published: February 2023

Osteonecrosis affecting the carpal bones is rare and is mostly seen in the lunate (Kienböck’s disease). Osteonecrosis of the scaphoid (Preiser disease) is even rarer. There are only four individual case reports published on patients presenting with trapezium necrosis, none with previous history of corticosteroid injection. This case report is the first presentation of isolated trapezial necrosis in the setting of prior corticosteroid injection for thumb basilar arthritis. Level of Evidence: Level V (Therapeutic)
Optimal Hemostatic Band Duration After Transradial Angiography or Intervention: Insights From a Mixed Treatment Comparison Meta-Analysis of Randomized Trials
Authors: Maqsood Muhammad Haisum , Pancholy Samir , Tuozzo Kristin A. , Moskowitz Nicole , Rao Sunil V. , Bangalore Sripal 
Published: February 2023

Background:
The optimal duration of hemostatic compression post transradial access is controversial. Longer duration increases the risk of radial artery occlusion (RAO) while shorter duration increases the risk of access site bleeding or hematoma. As such, a target of 2 hours is typically used. Whether a shorter or longer duration is better is not known.

Methods:
A PubMed, EMBASE, and clinicaltrials.gov databases were searched for randomized clinical trials of different duration (<90 minutes, 90 minutes, 2 hours, and 2–4 hours) of hemostasis banding. The efficacy outcome was RAO, primary safety outcome was access site hematoma, and secondary safety outcome was access site rebleeding. Primary analysis compared the effect of various duration in reference to the 2 hours duration using a mixed treatment comparison meta-analysis.

Results:
Of the 10 randomized clinical trials included with 4911 patients, when compared to the 2-hour reference duration, there was a significantly higher risk of access site hematoma with 90 minutes (odds ratio, 2.39 [95% CI, 1.40–4.06]) and <90 minutes (odds ratio, 3.61 [95% CI, 1.79–7.29]) but not with the 2 to 4 hours duration. When compared with the 2-hour reference, there was no significant difference in access site rebleeding or RAO with shorter or longer duration but the point estimates favored longer duration for access site rebleeding and shorter duration for RAO. Duration of <90 minutes and 90 minutes ranked 1 and duration of 2 hours ranked 2 as the most efficacious duration whereas duration of 2 hours ranked 1 and 2 to 4 hours ranked 2 as the safest duration.

Conclusions:
In patients undergoing transradial access for coronary angiography or intervention, a hemostasis duration of 2 hours offers the best balance for efficacy (prevention of RAO) and safety (prevention of access site hematoma/rebleeding).
Cardiac Myocyte‐Specific Overexpression of FASTKD1 Prevents Ventricular Rupture After Myocardial Infarction
Authors: Marshall Kurt D. , Klutho Paula J. , Song Lihui , Roy Rajika , Krenz Maike , Baines Christopher P. 
Published: February 2023

Background
The mitochondrial mRNA‐binding protein FASTKD1 (Fas‐activated serine/threonine [FAST] kinase domain–containing protein 1) protects myocytes from oxidative stress in vitro. However, the role of FASTKD1 in the myocardium in vivo is unknown. Therefore, we developed cardiac‐specific FASTKD1 transgenic mice to test the effects of this protein on experimental myocardial infarction (MI).

Methods and Results
Transgenic mouse lines with cardiac myocyte‐specific overexpression of FASTKD1 to varying degrees were generated. These mice displayed normal cardiac morphological features and function at the gross and microscopic levels. Isolated cardiac mitochondria from all transgenic mouse lines showed normal mitochondrial function, ATP levels, and permeability transition pore activity. Male nontransgenic and transgenic mice from the highest‐expressing line were subjected to 8 weeks of permanent coronary ligation. Of nontransgenic mice, 40% underwent left ventricular free wall rupture within 7 days of MI compared with 0% of FASTKD1‐overexpressing mice. At 3 days after MI, FASTKD1 overexpression did not alter infarct size. However, increased FASTKD1 resulted in decreased neutrophil and increased macrophage infiltration, elevated levels of the extracellular matrix component periostin, and enhanced antioxidant capacity compared with control mice. In contrast, markers of mitochondrial fusion/fission and apoptosis remained unaltered. Instead, transcriptomic analyses indicated activation of the integrated stress response in the FASTKD1 transgenic hearts.

Conclusions
Cardiac‐specific overexpression of FASTKD1 results in viable mice displaying normal cardiac morphological features and function. However, these mice are resistant to MI‐induced cardiac rupture and display altered inflammatory, extracellular matrix, and antioxidant responses following MI. Moreover, these protective effects were associated with enhanced activation of the integrated stress response.
Right Ventricular Function During Exercise After Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary Hypertension
Authors: Braams Natalia J. , Kianzad Azar , Meijboom Lilian J. , Westenberg Jesper , Spruijt Onno A. , Smits Josien , Vonk Noordegraaf Anton , Boonstra Anco , Nossent Esther J. , Oosterveer Frank , Handoko M. Louis , Symersky Petr , de Man Frances S. , Bogaard Harm Jan 
Published: February 2023

Background
Pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension improves resting hemodynamics and right ventricular (RV) function. Because exercise tolerance frequently remains impaired, RV function may not have completely normalized after PEA. Therefore, we performed a detailed invasive hemodynamic study to investigate the effect of PEA on RV function during exercise.

Methods and Results

In this prospective study, all consenting patients with chronic thromboembolic pulmonary hypertension eligible for surgery and able to perform cycle ergometry underwent cardiac magnetic resonance imaging, a maximal cardiopulmonary exercise test, and a submaximal invasive cardiopulmonary exercise test before and 6 months after PEA. Hemodynamic assessment and analysis of RV pressure curves using the single‐beat method was used to determine load‐independent RV contractility (end systolic elastance), RV afterload (arterial elastance), RV–arterial coupling (end systolic elastance–arterial elastance), and stroke volume both at rest and during exercise. RV rest‐to‐exercise responses were compared before and after PEA using 2‐way repeated‐measures analysis of variance with Bonferroni post hoc correction. A total of 19 patients with chronic thromboembolic pulmonary hypertension completed the entire study protocol. Resting hemodynamics improved significantly after PEA. The RV exertional stroke volume response improved 6 months after PEA (79±32 at rest versus 102±28 mL during exercise;
P
<0.01). Although RV afterload (arterial elastance) increased during exercise, RV contractility (end systolic elastance) did not change during exercise either before (0.43 [0.32–0.58] mm Hg/mL versus 0.45 [0.22–0.65] mm Hg/mL;
P
=0.6) or after PEA (0.32 [0.23–0.40] mm Hg/mL versus 0.28 [0.19–0.44] mm Hg/mL;
P
=0.7). In addition, mean pulmonary artery pressure–cardiac output and end systolic elastance–arterial elastance slopes remained unchanged after PEA.

Conclusions
The exertional RV stroke volume response improves significantly after PEA for chronic thromboembolic pulmonary hypertension despite a persistently abnormal afterload and absence of an RV contractile reserve. This may suggest that at mildly elevated pulmonary pressures, stroke volume is less dependent on RV contractility and afterload and is primarily determined by venous return and conduit function.