bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Temperature-Corrected Versus the Uncorrected PO2 During Hypothermic Cardiopulmonary Bypass-Correlation with Oxyhemoglobin Saturation
Authors: Baraka Anis S. , Musa K. Muallem , Baroody Maurice A. , Haroun Sania T. , Sibai Abla A. 
Published: August 2023

In 8 adult patients undergoing cardiopulmonary bypass, the perfusion flow was altered from 2.4 to 1.8 and 1.2 L/min/m2 during hypothermia (26.5 ± 2.3°C). Following rewarming of the patients to 37°C, the perfusion flow was also altered from 2.4 to 1.8 and 1.2 L/min/m2. The resulting mixed venous oxyhemoglobin saturation (SvO2) was measured in vivo by in-line oximetry at the actual body temperature, and was correlated with the corresponding temperature-corrected and uncorrected mixed venous oxygen tension (PvO2) as measured in the lab at 37°C. Venous blood at the entrance of the oxygenator was used for continuous in-line oximetry, blood gas sampling, and for measuring body temperature.
Correlation of SvO2 at the different perfusion flows with the corresponding temperature-corrected PvO2 during hypothermia is shifted to the leftofthecorrelation following rewarming ofthe patients to 37°C. In contrast, correlation of SvO2 with the uncorrected PvO2 is not significantly different from the normothermic relationship. Also, the uncorrected PvO2 and SvO2 during hypothermia at a perfusion flow of 1.2 L/min/m2 were not significantly different from that achieved during normothermia at a flow of 2.4 L/min/m2 Thus, maintenance of the temperature-uncorrected PO2 during hypothermia at the normal normothermic value facilitates clinical interpretation and reflects a normal oxyhemoglobin saturation, irrespective of changing the body temperature.
Safe, Compact and Portable System for Regional Chemotherapeutic Hyperthermic Perfusion Procedures
Authors: Fried Steven J. , Miller Randy , Weaver Fred A. , Faddis David 
Published: August 2023

Perfusion techniques utilizing hyperthermic chemotherapy have been established as a successful modality of therapy for isolated metastatic malignant melanoma. The combination of chemotherapeutic agents (Dactinomycin, thiotepa and Mechlorethamine HCl) given in high doses, not possible systemically, combined with hyperthermia ( 40-42°C) in an isolated extremity has shown greater tumor regression compared with systemic medication only.
Many of the isolated limb perfusion procedures are performed in non-cardiac centers, especially at specialized cancer institutions. This often presents new obstacles for the perfusionist including lack of adequate perfusion equipment and disposables. Other obstacles include unfamiliarity of the operating room staff with the heart-lung machine and inappropriate and/or unsafe handling of the perfusion circuit. In order to overcome these obstacles and enhance safety, portability and effectiveness, the authors have developed an isolated limb perfusion system.
The purpose of this study was to compare the parameters of treatment and long term outcomes demonstrated by our system and method, to previously published data. The qualitative comparative analysis was performed between eight treatments with this type of perfusion system and outcome data previously published. It is the authors’ conclusion that the portable isolated limb perfusion system achieved all of the required parameters to provide safe and effective treatment for this type of melanoma. No demonstrated variation of the long term clinical results in our patient population was seen when compared to previously published data.
A Comparison of Estimation of Blood Volume by Hematocrit Dilution with Prediction of Blood Volume by Patient Morphology
Authors: Acsell Jeffrey R. , Riley Jeffrey B. , Ecklund Jodie M. 
Published: August 2023

Determination of circulating blood volume (CBV) is useful for quantifying and managing several physiologic parameters in patients undergoing cardiopulmonary bypass (CPB). Blood was drawn and the hematocrit (HCT) measured immediately pre and five minutes post initiation of CPB, in adult cardiac surgery patients (n=67). The CBV was estimated by HCT dilution, and compared utilizing regression analysis and Student's t-test, with eight formulas for predicting CBV from patient morphology.

CBV by HCT dilution vs Patient Morphology (T-Test) P value
1) ml/kg 65ml/kg <.0001
2) Allen-men Height3* Body mass (H*TBM) .0001
3) Allen-wmn Height3* Body mass (H*TBM) <.0001
4) Baker 2.68L/m2 <.0001
5) Nadler1-men Regression of Baker <.0001
6) Nadler1-wmn Regression of Baker .0001
7) Nadler2-men Regression of Allen-men <.0001
8) Nadler2-wmn Regression of Allen-wmn .0002

There is a significant statistical difference between CBV estimated by HCT dilution and CBV predicted by patient morphology. None of the equations investigated are adequate predictors of CBV estimated by HCT dilution in patients undergoing CPB.
Do Sonoclot Coagulation Parameters Correlate with Thrombelastograph Parameters?
Authors: Meherg Lem , Riley Jeffrey B. , Wolk Dennis R. 
Published: August 2023

Postoperative hemorrhage is a major cause of morbidity after cardiopulmonary bypass. Timely coagulation test results may aid the clinician in diagnosing and treating coagulopathy. The purpose of this study is to determine if there is any correlation between parameters obtained from two viscoelastic coagulation monitors (Thrombelastograph and Sonoclot). Fifty non-heparinized blood samples were obtained from cardiac surgery patients pre-skin incision or post-Protamine. Each blood sample was placed in the Celite-activated Sonoclot cuvette and native, as well as Celitc-activatcd TEG wells. The parameters compared were: native and Celite TEG split point, r, k, alpha angle, MA, MA60 vs. Sonoclot immersion point, SonACT, R1, shoulder point, time to shoulder, R2, peak, time to peak, R3, retraction point and time to retraction. All viscoelastic parameters were correlated with routine coagulation tests including: ACT, PT, PTT, platelet count, fibrinogen concentration, bleeding time and hematocrit.
Simple and multiple regressions were performed on these Thromhelastograph and Sonoclot parameters to determine correlation, if any.
Correlations were considered significant if p<0.01 and R2 > 0.6. The Sonoclot R1 correlated significantly with the Thromhelastograph Celite-activated k-time and alpha angle. The Sonoclot shoulder point correlated with the Thrombelastograph Celite-activated MA and Coagulation Index. The Sonoclot R1 and shoulder point correlated with fibrinogen and platelet counts. The Sonoclot time to peak and time to retraction correlated with the PTT. The Sonoclot coagulation parameters generally do not correlate with the Thrombelastograph parameters. The lack of better correlation among all parameters suggests that there are aspects of coagulation that arc detected differently by each monitor. Therefore, the two viscoelastic monitors cannot be substituted for each other.
An In Vitro Protocol for Evaluation and Comparison of Membrane Oxygenators
Authors: Vocelka Craig R. , Burdge Eric C. , Kunzelman Karyn S. , Thomas Robert , Verrier Edward D. 
Published: August 2023

With the trend in open heart surgery toward normothermic bypass and warm blood cardioplegia, greater demand is being placed on the perfusionist to select an oxygenator that will perform safely and efficiently under a variety of conditions. While manufacturers report performance parameters for their products, the data is often not comparable due to widely differing conditions. Recent in vitro evaluation techniques employed to characterize membrane oxygenators do not simulate the actual oxygenator conditions observed during cardiopulmonary bypass. Biocompatibility and drug delivery are reported but comparisons of different oxygenator performance parameters are not completely addressed. We have designed a test circuit and an evaluation protocol to simultaneously characterize the performance of multiple oxygenators under identical conditions. The test circuit is designed to simulate clinical conditions and to evaluate gas exchange, blood path pressures, gas path pressures, and hemolysis.
Previously reported studies have relied on a comparison of a single membrane oxygenator and a single bubble oxygenator. Our protocol will compare multiple membrane oxygenators, in vitro, under similar clinically relevant conditions. Such testing would be done prior to animal or clinical trials. Furthermore in vitro tests should be more reproducible and more discriminating than are ex vivo tests.
Comparative Analysis of Recovery of Cardiopulmonary Bypass Residual Blood: Cell Saver vs. Hemoconcentrator
Authors: Johnson Howard D. , Morgan Marc S. , Utley Joe R. , Leyand Steven A , Nguyen-Duy Tuan , Crawley Debbie M 
Published: August 2023

For surgical bleeding problems, the cell saver has been used to return shed blood; however, overuse can lead to a deficit in coagulation factors. Its usefulness has gained widespread use in many surgical settings.
The hemoconcentrator can aid in raising the hematocrit level while reducing blood utilization where large blood volume and/or large amounts of irrigation are returned to the perfusion circuit. The hemoconcentrator returns red blood cells without removing coagulation factors, unlike the cell saver.
In order to determine which method of returning residual blood from the cardiopulmonary bypass circuit is more desirable, blood samples were drawn both pre and post transfusion from 15 cell saver patients, and 14 hemoconcentrator patients. Twelve hour blood loss was recorded in 40 patients within each group.
The fibrinogen, platelet count, total protein, albumin and white blood cell count were similar between the two groups, as was the blood loss. The only significant differences found were the post red blood cell count, post hemoglobin, and the delta hematocrit, all being higher in autotransfusion group.
In conclusion, returning blood through the hemoconcentrator in the average adult perfusion circuit was not able to significantly raise certain coagulation parameters, nor reduce postoperative bleeding.
Wahlfreiheit im Gesundheitswesen – und ihre Auswirkungen auf
den Wettbewerb
Authors: Bataille Marc , Wambach Achim 
Published: August 2023

ZusammenfassungDas deutsche Gesundheitssystem wurde in den letzten Jahrzehnten sukzessive
umgestaltet, um mehr Effizienz durch mehr Wettbewerbselemente zu erreichen.
Gleichzeitig sind die potenziellen Möglichkeiten der Patientinnen und
Patienten, sich über die verschiedenen Angebote von Versicherungen und
Leistungserbringern zu informieren, durch die Digitalisierung stark gestiegen.
Trotz dieser Voraussetzungen wird die Qualität im Gesundheitswesen heute
jedoch nur teilweise durch die Entscheidungen der Patientinnen und Patienten
gesteuert. Der Beitrag identifiziert die bestehenden Wettbewerbshemmnisse aus
Sicht der Wahlfreiheit. Auf der Nachfrageseite sind dies Informationsdefizite
über die medizinische Qualität, die durch einen Beratungsauftrag
der Krankenkassen abgebaut werden könnten. Auf Seiten der Versicherer
werden die langfristigen Anreize zur Versorgung der Patientinnen und Patienten
durch die derzeitige Ausgestaltung des Risikostrukturausgleichs reduziert.
Dieser sollte sich an den langfristig zu erwartenden Versorgungskosten
orientieren.
Primär- und Sekundärprävention bei Hypercholesterinämie – versorgungsrelevante Unterschiede in der PROCYON-Studie
Authors: Makhmudova Umidakhon , Wolf Michaela , Willfeld Kathy , Beier Lea , Weingärtner Oliver 
Published: August 2023

Zusammenfassung
Hintergrund Herz-Kreislauf-Erkrankungen sind für ein Drittel der Todesfälle in Deutschland verantwortlich. Erhöhte Spiegel des Low-Density-Lipoprotein-Cholesterols (LDL-C) gelten als ein wesentlicher Risikofaktor. Die Senkung des LDL-C-Spiegels ist daher integraler Bestandteil der Prävention kardiovaskulärer Ereignisse.
Methoden Ziel dieser Arbeit ist es, in einer post-hoc ausgeführten Gegenüberstellung von Querschnittsdaten aus der Umfrage PROCYON potenzielle Unterschiede zwischen der Primärprävention (PP) und der Sekundärprävention (SP) zu identifizieren. Es wurden Anamnese, Begleiterkrankungen, Adhärenz und Krankheitsbewusstsein in Bezug auf die Hypercholesterinämie abgefragt.
Ergebnisse An der Befragung nahmen 5494 Patient*innen teil (PP: 3798; SP 1696). Der Vergleich der Ergebnisse zeigte einen numerisch höheren Anteil von Frauen (PP 70,7% vs. SP 42,5%) sowie häufigere Komorbiditäten wie Bluthochdruck (PP 45,6% vs. SP 61,0%), Adipositas (PP 20,9% vs. SP 27,4%) und Diabetes mellitus Typ 2 (PP 14,1% vs. SP 23,8%). In der Primärprävention wurde die Hypercholesterinämie-Diagnose zumeist in der Vorsorgeuntersuchung gestellt (PP 74,6%), in der Sekundärprävention geschah dies am häufigsten im Laufe eines kardiovaskulär bedingten Krankenhausaufenthalts (SP 58,0%). Ein/e Kardiolog*in wurde von 16,3% (PP) bzw. 54,0% (SP) konsultiert. Mindestens halbjährliche LDL-C-Kontrollen (PP 46,8% vs. SP 77,9%) sowie eine medikamentöse Intervention (PP 43,0% vs. SP 87,0%) waren in der Sekundärpräventionsgruppe häufiger. Außerdem zeigten sich Unterschiede in der Umsetzung von Veränderungen im Lebensstil, der Verbesserung der LDL-C-Werte, der Anpassung der Therapie sowie der Adhärenz, Therapiezufriedenheit und Informiertheit der Patient*innen.
Schlussfolgerung Der Vergleich der Primär- und Sekundärprävention aus der Umfrage PROCYON zeigt insgesamt eine bessere Ausschöpfung der Therapieoptionen und eine höhere Versorgungsintensität in der Gruppe der Sekundärprävention. In beiden Gruppen besteht jedoch noch großes Verbesserungspotenzial, um eine effiziente Prävention kardiovaskulärer Ereignisse sicherzustellen.
Stratifying High-Risk Thyroid Nodules Using a Novel Deep Learning
System
Authors: Fu Chia-Po , Yu Ming-Jen , Huang Yao-Sian , Fuh Chiou-Shann , Chang Ruey-Feng 
Published: August 2023

Abstract
Introduction The current ultrasound scan classification system for thyroid
nodules is time-consuming, labor-intensive, and subjective. Artificial
intelligence (AI) has been shown to increase the accuracy of predicting the
malignancy rate of thyroid nodules. This study aims to demonstrate the
state-of-the-art Swin Transformer to classify thyroid nodules.
Materials and Methods Ultrasound images were collected prospectively from
patients who received fine needle aspiration biopsy for thyroid nodules from
January 2016 to June 2021. One hundred thirty-nine patients with malignant
thyroid nodules were enrolled, while 235 patients with benign nodules served as
controls. Images were fed to Swin-T and ResNeSt50 models to classify the thyroid
nodules.
Results Patients with malignant nodules were younger and more likely male
compared to those with benign nodules. The average sensitivity and specificity
of Swin-T were 82.46% and 84.29%, respectively. The average
sensitivity and specificity of ResNeSt50 were 72.51% and 77.14%,
respectively. Receiver operating characteristics analysis revealed that the area
under the curve of Swin-T was higher (AUC=0.91) than that of ResNeSt50
(AUC=0.82). The McNemar test evaluating the performance of these models
showed that Swin-T had significantly better performance than ResNeSt50.Swin-T classifier can be a useful tool in helping shared decision-making between
physicians and patients with thyroid nodules, particularly in those with
high-risk characteristics of sonographic patterns.
A Mega-Ethnography of Qualitative Meta-Syntheses on Return to Work in
People with Chronic Health Conditions
Authors: Schwarz Betje , Banaschak Hannes , Heyme Rebekka , von Kardorff Ernst , Reims Nancy , Streibelt Marco , Bethge Matthias 
Published: August 2023

Abstract
Purpose The aim of this study was to synthesize the findings of
qualitative meta-syntheses (QMS) on return to work (RTW) of people with
different chronic illnesses and to develop a generic RTW model that can provide
advice on how to improve RTW interventions and strategies.
Methods We conducted a systematic literature search in PubMed,
Epistemonikos, CENTRAL, and PsycARTICLES to find relevant QMS, published in
English or German between 2000 and 2021, and adapted the meta-ethnographic
approach of Noblit and Hare to synthesize their findings.
Results Nineteen QMS (five focusing on musculoskeletal disorders or
chronic pain, four on acquired or traumatic brain injuries, four on cancer, two
on mental disorders, one on spinal cord injury, and three on mixed samples) met
our inclusion criteria for the meta-ethnographic synthesis. Through systematic
comparison and reciprocal translation of the single QMS findings, we could
identify a set of key cross-cutting themes/concepts, which formed the
basis for four RTW principles and a generic RTW model.
Conclusions RTW is a multifactorial and highly interactive
multistakeholder process, embedded in an individual‘s life and working
history, as well as in a determined social and societal context. It runs
parallel and interdependently to the process of coping with the disease and
realigning one’s own identity, thus emphasizing the significance of RTW
for the person. Besides symptoms and consequences of the disease, individual
coping strategies, and RTW motivation, the course and success of RTW are
strongly affected by the adaptability of the person’s working
environment and the social support in their private and working life. Thus, RTW
is not only a problem of the individual, but also a matter of the social
environment, especially the workplace, requiring a holistic, person-centered,
and systemic approach, coordinated by a designated body, which considers the
interests of all actors involved in the RTW process.
Synthetic Utility of N-Acylbenzotriazoles
Authors: Tiwari Vinod K. , Yadav Mangal S. , Gupta Abhishek , Bose Priyanka , Singh Anoop S. , Mohapatra Prabhu P. 
Published: August 2023

Abstract
N-Acylbenzotriazoles are valuable synthons in organic synthesis. They are particularly used as acylating agents and an alternative to acyl chlorides. They have been widely explored for a diverse range of applications. This review summarizes methods for the preparation of N-acylbenzotriazole derivatives and their diverse applications, in particular demonstrating their ability to serve as alternative acylating agents in organic transformations such as N-, O-, C-, and S-acylating agents for the convenient synthesis of a wide range of biologically important organic compounds. We also emphasize the synthesis of diverse compounds using benzotriazole ring cleavage (BtRC) methodology, including its pharmacophore study and some notable utilities as valuable starting materials, ligands, and intermediates in the field of organic synthesis.1	Introduction2	Synthesis of N-Acylbenzotriazoles3	Applications of N-Acylbenzotriazoles in Organic Synthesis3.1	N-Acylation Using N-Acylbenzotriazoles3.2	C-Acylation of Heterocycles Using N-Acylbenzotriazoles3.3	Preparation of β-Keto Esters and β-Diketones by Acylative Deacetylation3.4	N-Acylbenzotriazoles Used for the Preparation of Other Valuable Intermediates3.5	Benzotriazole Ring Cleavage (BtRC) Reactions4	N-Acylbenzotriazoles as Catalysts and Ligands5	Pharmacological Applications of N-Acylbenzotriazoles6	Conclusions and Future Outlook
A Practical and Efficient Method for the Synthesis of Sorafenib and Regorafenib
Authors: Gill Manjinder Singh , Prachi Ramteke 
Published: August 2023

AbstractEfficient, practical syntheses of sorafenib and regorafenib have been achieved in a manner that is free from the problems associated with previously reported methods. The process involved preparation of 4-(4-aminophenoxy)-N-methylpicolinamide (sorafenib intermediate) and 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide (regorafenib intermediate) using only a single base and did not require the use of an inert atmosphere. The reaction of intermediates with phenyl 4-chloro-3-(trifluoromethyl)phenyl carbamate, prepared using water-assisted synthesis of carbamates, was used to install the main urea functionality in these molecules.
Review: The Chemistry, Toxicity and Antibacterial Activity of Curcumin and Its Analogues
Authors: Denison Hannah J. , Schwikkard Sianne L. , Khoder Mouhamad , Kelly Alison F. 
Published: August 2023

AbstractAntimicrobial resistance is a global challenge that is already exacting a heavy price both in terms of human health and financial cost. Novel ways of approaching this crisis include the
investigation of natural products. Curcumin is the major constituent in turmeric, and it is commonly used in the preparation of Asian cuisine. In addition, it possesses a wide range of
pharmacological properties. This review provides a detailed account of curcumin and its analoguesʼ antibacterial activity against both gram-positive and gram-negative isolates, including its
potential mechanism(s) of action and the safety and toxicity in human and animal models. We also highlight the key challenges in terms of solubility/bioavailability associated with the use
of curcumin and include research on how these challenges have been overcome.
Image Quality and Related Outcomes of the ShuntScope-Guided Catheter Implantation in Adult Hydrocephalus: Experience of 63 Procedures
Authors: Prajsnar-Borak Anna , Teping Fritz , Oertel Joachim 
Published: August 2023

Abstract
Background Ventricular catheter (VC) placement in the selected subset of adult hydrocephalus can be highly challenging due to abnormal anatomical configuration or the need for trans-aqueductal stent placement. Transluminal endoscopy with the ShuntScope has been invented to increase the success rate of catheter placement. This study evaluates the image qualities of ShuntScope and related surgical outcomes in adults.
Methods A retrospective analysis of all adult patients undergoing VC placement using the ShuntScope from November 2011 to July 2022 in the authors' department was performed. Demographic, clinical, and radiologic data were evaluated. The visualization quality of the intraoperative endoscopy was stratified into excellent, medium, and poor, and compared to the postoperative catheter tip placement. Follow-up evaluation included the surgical revision rate due to proximal catheter misplacement.
Results A total of 63 ShuntScope-assisted surgeries have been performed on 60 adults. The mean age of the patients was 48.43 years. The most common underlying pathology was a tumor- or cyst-related cerebrospinal fluid (CSF) impairment in 38.33%, followed by a pseudotumor cerebri in 21.66%. The achieved image quality was excellent in 39.68%, medium in 47.62%, and poor in 12.7%. Ideal catheter placement was achieved in 79.37%. There were no intraoperative complications associated with the use of the ShuntScope. The revision rate due to suboptimal proximal VC placement was 4.76% during a mean follow-up period of 27.75 months. A statistical correlation between the image quality and accuracy of the catheter position was observed (p < 0.001).
Conclusion The ShuntScope can be considered an important addition to standard surgical tools in treating a selected subset of adult hydrocephalus. Direct visualization might even help achieve correct placement of the catheter in the cases with blurred vision and limited visual overview.