bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of clear aligner to move mandibular first molar distally using finite element method.
Authors: Kang Fujia , Zhang Xiya , Zhang Han , Wu Yumiao , Wang Songqing , Yuan Jiamin , Hu Zhiqiang , Zhu Xianchun 
Published: May 2023

Abstract
Objectives To analyze the features of tooth movement with clear aligner(CA) under different starting point and attachment settings.Materials and methods A 3D finite element(FE) model was established including mandible, dentition, periodontal ligaments(PDLs), CA and horizontal rectangular attachment. The second molar was previously positioned 3.2mm distally. Three groups were created according to attachment setting: (1)no attachment, (2)attachment on the second molar, (3) attachment on the first molar. In each group, the starting point of the first molar was 0mm(SET1), 1mm(SET2), 2mm(SET3) and 3mm(SET4) to the premolar in turn. A distal moving distance of 0.2 mm was applied to the first molar.Results As the first molar got closer to the second molar, distal displacement of the first molar, mesial displacement of premolar and labial displacement of anterior teeth increased, while the mesial displacement of the second molar decreased. When the attachment was applied on the buccal surface of the first molar, the average displacement value reached the top for the first molar(6.79e− 2mm), premolar(2.72e− 2mm) and anterior teeth(2.59e− 2mm) in SET 4. The average displacement of the second molar reached the top(3.07e− 2mm) in SET1 when attachment was placed on the second molar.Conclusions The distal displacement of the first molar resulted in an opposite movement of other teeth in dentition without additional anchorage. The effect of mesial and labial movement increased except for the second molar when the first molar moved distally. The horizontal rectangular attachment placed on the first molar produced more distal movement of the first molar crown.
Not easy-peasy to diagnose: familial Mediterranean fever unaccompanied by fever as neither always Mediterranean
Authors: Arık Selen Duygu , Kayaalp Gülşah Kavrul , Guliyeva Vafa , Demirkan Fatma Gül , Tanatar Ayşe , Akgün Özlem , Çağlayan Şengül , Ulu Kadir , Coşkuner Taner , Karadağ Şerife Gül , Sözeri Betül , Ayaz Nuray Aktay 
Published: May 2023

Abstract
Purpose Classical attacks of familial Mediterranean fever (FMF) are often accompanied by fever, but some of the patients have attacks without fever. This study aimed to compare the characteristics of FMF patients with and without fever during their attacks and draw attention to the different clinical presentations of FMF in children.Methods Medical files of patients aged 0–18 years who were followed up with the diagnosis of FMF in two reference pediatric rheumatology centers were reviewed retrospectively. The patients were divided into two groups: Children who had had no fever in any of their attacks were assigned as group 1, and those who had fever during their attacks were classified as group 2.Results Out of 2003 patients evaluated, 191 (9.53%) patients had attacks not accompanied by fever and their median age at onset of symptoms (7.0 vs. 4.0 years, p < 0.001) and the median age at diagnosis (8.6 vs. 6.0 years, p < 0.001) were significantly higher, however group 2 had delay in diagnosis. The annual number of attacks and abdominal attacks were more common in group 2, arthritis, arthralgia, erysipelas-like rash, exercise-induced leg pain, and myalgia were more common in group 1.Conclusion The data from the assessment of children with FMF attacks not accompanied with fever were presented for the first time. Children with late age onset of FMF and dominance of musculoskeletal features may display attacks not accompanied with fever.
Validity of low-magnification narrow-band imaging in annual endoscopy screening for gastric neoplasms: A case-control study
Authors: Nagashima Ryuichi 
Published: May 2023

Abstract
I have previously reported the efficacy of whole stomach observation using magnifying narrow-band imaging at low magnification (LM-NBI) after routine white light imaging (WLI). LM-NBI detects lesions missed on WLI. However, the validity of annual examinations are yet to be elucidated. This historical case-control study was conducted on patients with chronic gastritis at a single institution. The patients were divided into two groups: the LM-NBI group, which include patients who underwent whole stomach observations with LM-NBI, defined as the minimal magnification required to reveal the microsurface pattern of the gastric mucosa after WLI; and the conventional endoscopy (CE) group as the control. Investigations included an index endoscopy followed by approximately five annual endoscopes. A total of 388 patients were assigned to the LM-NBI group, whereas 381 were to the CE group. Fifteen cases of gastric neoplasia were identified in the LM-NBI group, and five cases in the CE group. A hazard ratio of 2.78 (95% CE, 1.01 to 7.64) was determined using a Cox proportional-hazards model, and using Kaplan–Meier analysis (p = 0.039, by log-rank test), annual LM-NBI was superior to CE in detecting gastric neoplasia. This is the first study to report the efficacy of annual endoscopies using LM-NBI.
A Monte Carlo model of the Dingo thermal neutron imaging beamline
Authors: Jakubowski Klaudiusz , Chacon Andrew , Tran Linh T. , Garbe Ulf , Bevitt Joseph , Olsen Scott , Franklin Daniel R. , Rosenfeld Anatoly , Guatelli Susanna , Safavi-Naeini Mitra 
Published: May 2023

Abstract
In this study, we present a validated Geant4 Monte Carlo simulation model of the Dingo thermal neutron imaging beamline at the Australian Centre for Neutron Scattering. The model, constructed using CAD drawings of the entire beam transport path and shielding structures, is designed to precisely predict the in-beam neutron field at the position at the sample irradiation stage. The model’s performance was assessed by comparing simulation results to various experimental measurements, including planar spatial thermal neutron distribution obtained in-beam using gold foil activation and 10B4C-coated microdosimeters and the out-of-beam neutron spectra measured with Bonner spheres. The simulation results demonstrated that the predicted neutron fluence at the field’s centre is within 8.1% and 2.1% of the gold foil and 10B4C-coated microdosimeter measurements, respectively. The logarithms of the ratios of average simulated to experimental fluences in the thermal (Eth < 0.414 eV), epithermal (0.414 eV < Eepi < 11.7 keV) and fast (Efast > 11.7 keV) spectral regions were approximately -0.03 to +0.1, -0.2 to +0.15, and -0.4 to +0.2, respectively. Furthermore, the predicted thermal, epithermal and fast neutron components in-beam at the sample stage position constituted approximately 18%, 64% and 18% of the total neutron fluence.
Revisiting the influence of emulsion droplets on the distribution of the active material inside spray dried microparticles
Authors: Fleury Fernanda Esteves , Kurozawa Louise , Prata Ana Silvia 
Published: May 2023

Abstract
The aim of this study was to investigate how an emulsifying agent behaves during the spray drying process. For this, the evolution of droplet size during the emulsion and redispersion in matrix phases were monitored as a function of the process conditions and formulations. The emulsions were prepared using maltodextrin and modified starch (Capsul) as wall materials, and d-limonene as the active compound. The increase in surfactant concentration favored the reduction in size of the oil droplets during the emulsification, atomization, drying and redispersion of the powder processes. A correlation was observed between the size of the oil droplets in the initial and reconstituted emulsion, with the encapsulation efficiency. Reconstituted emulsions with oil droplet sizes below 1 µm, led to encapsulation efficiency above 81.53%. The results confirm that the size of oil droplets in the emulsion and the surfactant concentration directly influences the process and the stability of the microparticles.
Malnutrition- Inflammation- Atherosclerosis (MIA) syndrome associates with periodontitis in end-stage renal disease patients undergoing hemodialysis: A cross-sectional study
Authors: Mikami Risako , Mizutani Koji , Gohda Tomohito , Matsuyama Yusuke , Gotoh Hiromichi , Nakagawa Keita , Takemura Shu , Aoyama Norio , Matsuura Takanori , Kido Daisuke , Takeda Kohei , Saito Natsumi , Izumi Yuichi , Iwata Takanori 
Published: May 2023

Abstract
Aim Malnutrition-inflammation-atherosclerosis (MIA) syndrome is a significant risk factor for mortality in patients undergoing hemodialysis. This study aimed to investigate the association between MIA syndrome and oral health status in hemodialysis patients.Material and methods A cross-sectional study was conducted on 254 hemodialysis patients. Comprehensive medical and dental examinations were performed. Three components were included to define MIA syndrome: albumin levels, serum high-sensitivity C-reactive protein, and history of cardiovascular events as indicators of malnutrition, inflammation, and atherosclerosis, respectively. The association of MIA syndrome components with periodontitis and occlusal support was examined by multiple-ordered logistic regression analysis.Results Of 254 participants, 170 (66.9%) had at least one component of MIA syndrome. After adjusting for possible confounding factors, severe periodontitis was significantly associated with presence of more components of MIA syndrome (odds ratio [OR]: 2.40, 95% confidence interval [CI], 1.33–4.34, p = 0.004) and inflammation and malnutrition components (OR: 2.21 and 3.31, 95% CI: 1.10–4.43 and 1.64–6.65, p = 0.030 and 0.001). On the other hand, occlusal support was not significantly associated with MIA syndrome or any of its components.Conclusion Periodontitis is associated with MIA syndrome, particularly with inflammation and malnutrition in hemodialysis patients, independent of occlusal support.
Effect of Citicoline on liver fat content in mice fed a high-fat diet, an experimental study
Authors: Sharifi Amrollah , Jarvand Zahra , Ghasemi Shima 
Published: May 2023

Abstract
Citicoline may have a beneficial role in the protection of hepatocytes because of its role in reducing oxidative stress and its choline part role in the production of VLDL. Choline deficiency leads to liver fat accumulation, which is treated by supplying choline. The purpose of this study was to investigate the hypothesis, of whether the administration of citicoline, the precursor of choline, in mice on a high-fat diet is effective in reducing the amounts of liver fat content.
Twenty-four male C57BL/6 mice, after 2 weeks on a high-fat (HF) diet, were randomly assigned to the 4 groups. Control: HF diet mice without intervention, dose 1: HF diet mice with a dose of 10 mg/kg Citicoline, dose 2: HF diet mice with an amount of 20 mg/kg citicoline, and dose 3: HF diet mice with an amount of 30 mg/kg Citicoline.
After 8 weeks, the mice’s body weights, liver weights, liver dry weights, and liver fat percentages were measured. All the aspects of ARRIVE and PREPARE guidelines were considered.
The differences in liver fat % between the control, dose 1, and dose 2 groups were not statistically meaningful (8.37 ± 0.39, 8.08 ± 0.65, 7.63 ± 0.55, and 7.34 ± 0.65 % for control, dose 1, dose 2, and dose 3 groups respectively; p for ANOVA test: 0.0381). A posthoc Tukey test showed that liver fat % was statistically different only between the control and dose 3 groups (mean diff: 1.03, 95%CI: 0.05 to 2.0).
The liver total weight and liver dry weight were not different between the groups (p= 0.94, and p= 0.66 respectively). The intervention did not affect the mice's body weights.
It seems that citicoline can be considered as a dietary supplement in the treatment of fatty liver. RCT studies are suggested to test this hypothesis.
BERT_PLPS: A BERT-based Model for Predicting Lysine Phosphoglycerylation Sites
Authors: Lai Songning , Cao Yankun , Wang Pengwei , Ye Lan , Liu Zhi 
Published: May 2023

Abstract
As one of the most important post-translational modification processes, lysine phosphoglycerylation modifications affect many important biosynthetic processes in the human body. However, traditional experimental methods for the recognization of lysine phosphoglycerylation sites are not only expensive but also time-consuming. Computational techniques may provide an economical and efficient way to predict lysine phosphoglycerylation sites. Therefore, it is extremely necessary and meaningful to study and establish prediction models with high accuracy. In the present study, we propose a BERT-based model, BERT_PLPS, which could predict accurately lysine phosphoglycerylation sites. This model extracts amino acid sequence features with three algorithms: CKSAAP, AAC, and BE. Sample equalization is performed using the ADASYN and KNN algorithms. The data are dimensionalized by the ISOMap algorithm, and the features are encoded into feature sequences by an encoder as the input to a BERT-based prediction model. To learn better the intrinsic biological language of lysine, we replaced the original static mask with a dynamic random mask. Compared to other machine learning or deep learning-based models, BERT_PLPS exhibits up to 99.53% accuracy and outperforms the most advanced model (PLP_FS) with an increase of approximately 0.35% on ACC and approximately 0.93% on MCC.
Relationship between Lip Seal Strength, Tongue Pressure, and Daytime Sleepiness in Japanese Workers: A Cross-Sectional Study
Authors: Minoura Akira , Ihara Yoshiaki , Kato Hirotaka , Murakami Kouzou , Watanabe Yoshio , Hirano Kojiro , Ito Yoshinori , Kokaze Akatsuki 
Published: May 2023

Abstract
Background: This cross-sectional study aimed to examine the relationship between lip seal strength, tongue pressure, and daytime sleepiness, among Japanese workers.
Methods: A self-administered questionnaire composed of Epworth Sleepiness Scale (ESS) was conducted on 496 workers, and excessive daytime sleepiness defined by an ESS score of 11 or over. Lip seal strength and tongue pressure were measured in all participants, and multiple regression analyses were performed to examine the effects of lip seal strength and tongue pressure on daytime sleepiness.
Results: The median ESS score was 5.0 (25th, 75th percentile: 2.0, 8.0), and 60 (12.1%) workers with excessive daytime sleepiness. The median lip-seal strength was 13.5 N (11.4, 16.3) and tongue pressure was 41.7 kPa (35.2, 48.3). Workers with excessive daytime sleepiness had significantly lower lip seal strength than did those without after adjustment for age and body mass index (BMI) (β (95% confidence interval): –0.043 [–0.081, –0.004]). However, tongue pressure was not significantly associated with excessive daytime sleepiness after adjustment for age and/or BMI.
Conclusions: These results suggest that maintaining moderate lip-seal strength may help prevent excessive daytime sleepiness in Japanese workers regardless of age or BMI.
Essentiality, Protein-Protein Interactions and Evolutionary Properties are Key Predictors for Identifying Cancer-Associated Genes Using Machine Learning
Authors: Safadi Amro , Lovell Simon C. , Doig Andrew 
Published: May 2023

Abstract

The distinctive nature of cancer as a disease prompts an exploration of the special characteristics the genes implicated in cancer exhibit. The identification of cancer-associated genes and their characteristics is crucial to further our understanding of this disease and enhanced likelihood of therapeutic drug targets success. However, the rate at which cancer genes are being identified experimentally is slow. Applying predictive analysis techniques, through the building of accurate machine learning models, is potentially a useful approach in enhancing the identification rate of these genes and their characteristics. Here, we investigated gene essentiality scores and found that they tend to be higher for cancer-associated genes compared to other protein-coding human genes. We built a dataset of extended gene properties linked to essentiality and used it to train a machine-learning model; this model reached 89% accuracy and > 0.85 for the Area Under Curve (AUC). The model showed that essentiality, evolutionary-related properties, and properties arising from protein-protein interaction networks are particularly effective in predicting cancer-associated genes. We were able to use the model to identify potential candidate genes that have not been previously linked to cancer. Prioritising genes that score highly by our methods could aid scientists in their cancer genes research.
Anatase-Cellulose Acetate for Preparing Antifouling Desalination Membrane
Authors: Abdel-Fatah Ahmed S. , Tohamy Hebat-Allah S. , Ahmed Sayed I. , Youssef Mohamed A. , Mabrouk Mohamed R. , Kamel Samir , Samhan Farag , El–Gendi Ayman 
Published: May 2023

Abstract
This study aimed to prepare antifouling and highly mechanical strengthening membranes for brackish and underground water desalination. It was prepared from cellulose acetate (CA) loaded anatase. Anatase was prepared from tetra-iso-propylorthotitanate and carboxymethyl cellulose. Different concentrations of anatase (0.2, 0.3, 0.5, 0.6, 0.7 and 0.8) % were loaded onto CA during the inversion phase preparation of the membranes. The prepared membranes were characterized using Fourier Transform Infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM & EDX), mechanical properties, swelling ratio, porosity determination, and ion release. The analysis confirmed the formation of anatase on surface and inside the macro-voids of the membrane. Furthermore, the loading of anatase improved the mechanical properties of the CA membrane and decreased its swelling and porosity rate. Also, CA-loaded anatase membranes displayed a significant antibacterial potential against Gram-positive and Gram-negative bacteria. It can be concluded that the prepared CA-loaded anatase membranes have high mechanical properties that are safe, economical, available, and can stop membrane biofouling.
Fatty acid composition of different structures in Macrocystis pyrifera (L.) C. Agardh from the sub-Antarctic Magellan Ecoregion: nutritional and biomedical potential
Authors: Méndez Fabio , Rivero Ali , Bahamonde Francisco , Gallardo Pablo , Frangopulos Máximo , Zolezzi Juan , Inestrosa Nibaldo C. , Mansilla Andrés 
Published: May 2023

AbstractThe sub-Antarctic Magellan Ecoregion is a unique biogeographic area located in the southern end of South America with notable marine flora and high endemism. Brown macroalgae, particularlyMacrocystis pyrifera, dominate the coastlines and are considered critical ecosystem engineers, providing shelter, food, and reproduction sites for various species. Additionally, they are essential components used in the food industry and biomedicine due to their lipids, amino acids, and fiber content. In this study, we determined the fatty acid content in different thallus structures (holdfast, stipes and fronds) ofMacrocystis pyriferacollected inRinconada Bulnes(53°35ʼ47.76” S; 70°56ʼ08.52” W) in the spring of 2021. The stipes had a highest total lipid content (3.73%) than the fronds (2.74%). The fatty acid profile showed higher values of monounsaturated fatty acids in the stipe (Ʃ 43.0%) and holdfast (Ʃ 41.7%), while fronds displayed higher values of polyunsaturated fatty acids (Ʃ 32.4%). This study provides insights into the nutritional and biomedical potential ofM. pyriferaand highlights the importance of understanding the distribution of fatty acids in different thallus structures.
Prolonged activation of EP3 receptor-expressing preoptic neurons underlies torpor responses
Authors: Machado Natalia , Raffin Francesca , Kaur Satvinder , Banks Alexander , Lynch Nicole , Fanari Oleksandra , Plascencia Oscar , Aten Sydney , Lima Janayna , Bandaru Sathyajit , Palmiter Richard , Arrigoni Elda , Saper Clifford 
Published: May 2023

Abstract
Many species use a temporary drop in body temperature and metabolic rate (torpor) as a strategy to survive food scarcity. A similar profound hypothermia is observed with activation of preoptic neurons that express the neuropeptides Pituitary Adenylate-Cyclase-Activating Polypeptide (PACAP)1, Brain Derived Neurotrophic Factor (BDNF)2, or Pyroglutamylated RFamide Peptide (QRFP)3, the vesicular glutamate transporter, Vglut2 4,5 or the leptin receptor6 (LepR), estrogen 1 receptor (Esr1)7 or prostaglandin E receptor 3 (EP3R) in mice8. However, most of these genetic markers are found on multiple populations of preoptic neurons and only partially overlap with one another. We report here that expression of the EP3R marks a unique population of median preoptic (MnPO) neurons that are required both for lipopolysaccharide (LPS)-induced fever9 and for torpor. These MnPOEP3R neurons produce persistent fever responses when inhibited and prolonged hypothermic responses when activated either chemo- or opto-genetically even for brief periods of time. The mechanism for these prolonged responses appears to involve increases in intracellular calcium in individual EP3R-expressing preoptic neurons that persist for many minutes up to hours beyond the termination of a brief stimulus. These properties endow MnPOEP3R neurons with the ability to act as a two-way master switch for thermoregulation.
Association between GGT to HDL-C ratio and NAFLD in the Japanese population: A cross-sectional study based on a public database
Authors: Zhao Yue , Luo Xiao-ping 
Published: May 2023

Abstract
Background The connection between γ-glutamyl transpeptidase to high-density lipoprotein cholesterol (GGT/HDL-C) ratio and nonalcoholic fatty liver disease (NAFLD) has been reported in some research. Few studies have discussed their possible nonlinear relationship in the Japanese population. We sought to learn the connection between the GGT/HDL-C and NAFLD in a Japanese population through a cross-sectional study.Methods Participants were from the NAGALA (NAfld in the Gifu Area, Longitudinal Analysis) medical examination program's database. This program aimed to investigate chronic disease risk factors and advance public health. Participants received exams per year. A cross-section study was employed. A total of 14242 subjects (7402 males and 6840 females) were enrolled after screening according to strict exclusion criteria. Fatty liver disease was confirmed by abdominal ultrasonography. The data was stated to have been posted to the DATADRYAD website.Results After adjusting for a series of confounding factors (age, sex, BMI, SBP, DBP, AST, ALT, FPG, HBA1C, TC, TG, smoking status, ethanol consumption, exercise status), GGT/HDL-C ratio quartile was positively related to NAFLD (P for trend < 0.0001). GGT/HDL-C was nonlinearly associated with NAFLD, with an inflexion point of 17.36. The effect sizes and the confidence intervals on the left and right sides of the inflexion point were 1.10 (1.07, 1.12) and 0.99 (0.99, 0.99), respectively. In different groups of ALT, the effect sizes of GGT/HDL-C on NAFLD showed significant differences (P for interaction was < 0.0001). The subsequent subgroup and interaction analysis found no statistical significance for the subgroup of age, sex, BMI, SBP, DBP, smoking and drinking status, and amount of exercise.Conclusion The GGT/HDL-C ratio is nonlinearly connected to NAFLD. Their positive connection can be established when GGT/HDL-C is less than or equal to 17.36.