bluuebunny/crossref_metadata_2025_split huggingface dataset:
Joint EANM/SNMMI procedure guideline for the use of 177Lu-labeled PSMA-targeted radioligand-therapy (177Lu-PSMA-RLT)
Authors: Kratochwil Clemens , Fendler Wolfgang P. , Eiber Matthias , Hofman Michael S. , Emmett Louise , Calais Jeremie , Osborne Joseph R. , Iravani Amir , Koo Phillip , Lindenberg Liza , Baum Richard P. , Bozkurt Murat Fani , Delgado Bolton Roberto C. , Ezziddin Samer , Forrer Flavio , Hicks Rodney J. , Hope Thomas A. , Kabasakal Levent , Konijnenberg Mark , Kopka Klaus , Lassmann Michael , Mottaghy Felix M. , Oyen Wim J. G. , Rahbar Kambiz , Schoder Heiko , Virgolini Irene , Bodei Lisa , Fanti Stefano , Haberkorn Uwe , Hermann Ken 
Published: May 2023

AbstractProstate-specific membrane antigen (PSMA) is expressed by the majority of clinically significant prostate adenocarcinomas, and patients with target-positive disease can easily be identified by PSMA PET imaging. Promising results with PSMA-targeted radiopharmaceutical therapy have already been obtained in early-phase studies using various combinations of targeting molecules and radiolabels. Definitive evidence of the safety and efficacy of [177Lu]Lu-PSMA-617 in combination with standard-of-care has been demonstrated in patients with metastatic castration-resistant prostate cancer, whose disease had progressed after or during at least one taxane regimen and at least one novel androgen-axis drug. Preliminary data suggest that 177Lu-PSMA-radioligand therapy (RLT) also has high potential in additional clinical situations. Hence, the radiopharmaceuticals [177Lu]Lu-PSMA-617 and [177Lu]Lu-PSMA-I&T are currently being evaluated in ongoing phase 3 trials. The purpose of this guideline is to assist nuclear medicine personnel, to select patients with highest potential to benefit from 177Lu-PSMA-RLT, to perform the procedure in accordance with current best practice, and to prepare for possible side effects and their clinical management. We also provide expert advice, to identify those clinical situations which may justify the off-label use of [177Lu]Lu-PSMA-617 or other emerging ligands on an individual patient basis.
Bone marrow biopsy can be omitted in the diagnostic workup of CNS lymphoma of DLBCL origin: a population-based retrospective study in the PET-CT era
Authors: Jelicic Jelena , Hansen Dennis Lund , Carlsen Sarah Sand , Thorsgaard Michael , Hersby Ditte Stampe , Kannik Karina , Munksgaard Amalie Sofie Eilsø , Larsen Thomas Stauffer , Juul-Jensen Karen 
Published: May 2023

AbstractCurrently, bone marrow (BM) biopsy (BMB) is recommended in the initial staging of patients with the presumed primary central nervous system (CNS) lymphoma (PCNSL). However, the added value of BMB in the era of positron emission tomography (PET-CT) has been challenged in other lymphoma subtypes. We analyzed BM findings in patients with biopsy-proven CNS lymphoma and a negative PET-CT scan for disease outside CNS. A comprehensive Danish population-based registry search was performed to identify all patients with CNS lymphoma of diffuse large B cell lymphoma (DLBCL) histology with available BMB results and staging PET-CT without systemic lymphoma. A total of 300 patients fulfilled the inclusion criteria. Of them, 16% had a previous history of lymphoma, while 84% were diagnosed with PCNSL. None of the patients had DLBCL in the BM. A minority (8.3%) had discordant BMB findings, mainly low-grade histologies that did not influence treatment choice in any case. In conclusion, the risk of overlooking concordant BM infiltration in patients with CNS lymphoma of DLBCL histology and negative PET-CT scan is negligible. As we did not find any patient with DLBCL in the BMB, our results suggest that BMB can be safely omitted in the diagnostic workup in patients with CNS lymphoma and a negative PET-CT.
Surgical treatment of ankle instability in children with os subfibulare
Authors: Zgoda Marcin , Arnold Matthew C. A. 
Published: May 2023

Abstract
Introduction
Ankle instability in children due to soft tissue injury usually resolves after non-operative treatment. However, some children and adolescents with chronic instability require surgical treatment. A rarer cause of developing ankle instability is injury to the ligament complex in the presence of os subfibulare, an accessory bone inferior to the lateral malleolus. The aim of this study was to assess the results of operative management of chronic ankle instability in children with os subfibulare.

Materials and methods
16 children with os subfibulare and chronic ankle instability who failed non-operative treatment were enrolled prospectively into the study. One child was lost to follow-up and excluded from analysis. The mean age at the time of the surgery was 14 years and 2 months (range 9.5–17 years). The mean follow-up time was 43.2 months (range 28–48 months). Surgical treatment in all cases involved removal of os subfibulare and a modified Broström-Gould lateral complex reconstruction with anchors. Ankle status was assessed before and after surgery with The 100 mm Visual Analogue Scale and Foot and Ankle Outcome Score questionnaire.

Results
The mean Foot and Ankle Outcome Score improved from 66.8 to 92.3 (p < 0.001). Pain level improved from 67.1 preoperatively to 12.7 (p < 0.001). All children reported improvement in their ankle stability. There was one case of scar hypersensitivity that improved during observation and one superficial wound infection that resolved with oral antibiotics. One child reported intermittent pain without symptoms of instability following another injury.

Conclusions
Ankle joint sprain with associated injury to os subfibulare complex can lead to chronic instability in children. If conservative management fails, then surgical treatment with modified Broström-Gould technique and excision of accessory bone is a safe and reliable method.
Combined exposure to heavy physical workload and low job control and the risk of disability pension: A cohort study of employed men and women in Sweden
Authors: Badarin Kathryn , Hemmingsson Tomas , Almroth Melody , Falkstedt Daniel , Hillert Lena , Kjellberg Katarina 
Published: May 2023

Abstract
Objective
To investigate the separate and combined effects of overall heavy physical workload (PWL) and low decision authority on all-cause disability pension (DP) or musculoskeletal DP.

Methods
This study uses a sample of 1,804,242 Swedish workers aged 44–63 at the 2009 baseline. Job Exposure Matrices (JEMs) estimated exposure to PWL and decision authority. Mean JEM values were linked to occupational codes, then split into tertiles and combined. DP cases were taken from register data from 2010 to 2019. Cox regression models estimated sex-specific Hazard Ratios (HR) with 95% confidence intervals (95% CI). The Synergy Index (SI) estimated interaction effects.

Results
Heavy physical workload and low decision authority were associated with an increased risk of DP. Workers with combined exposure to heavy PWL and low decision authority often had greater risks of all-cause DP or musculoskeletal DP than when adding the effects of the single exposures. The results for the SI were above 1 for all-cause DP (men: SI 1.35 95%CI 1.18–1.55, women: SI 1.19 95%CI 1.05–1.35) and musculoskeletal disorder DP (men: SI 1.35 95%CI 1.08–1.69, women: 1.13 95%CI 0.85–1.49). After adjustment, the estimates for SI remained above 1 but were not statistically significant.

Conclusion
Heavy physical workload and low decision authority were separately associated with DP. The combination of heavy PWL and low decision authority was often associated with higher risks of DP than would be expected from adding the effects of the single exposures. Increasing decision authority among workers with heavy PWL could help reduce the risk of DP.
Robotic versus laparoscopic versus open major hepatectomy – an analysis of costs and postoperative outcomes in a single-center setting
Authors: Knitter Sebastian , Feldbrügge Linda , Nevermann Nora , Globke Brigitta , Galindo Santiago Andres Ortiz , Winklmann Thomas , Krenzien Felix , Haber Philipp K. , Malinka Thomas , Lurje Georg , Schöning Wenzel , Pratschke Johann , Schmelzle Moritz 
Published: May 2023

Abstract

Purpose
In the era of minimal-invasive surgery, the introduction of robotic liver surgery (RS) was accompanied by concerns about the increased financial expenses of the robotic technique in comparison to the established laparoscopic (LS) and conventional open surgery (OS). Therefore, we aimed to evaluate the cost-effectiveness of RS, LS and OS for major hepatectomies in this study.

Methods
We analyzed financial and clinical data on patients who underwent major liver resection for benign and malign lesions from 2017 to 2019 at our department. Patients were grouped according to the technical approach in RS, LS, and OS. For better comparability, only cases stratified to the Diagnosis Related Groups (DRG) H01A and H01B were included in this study. Financial expenses were compared between RS, LS, and OS. A binary logistic regression model was used to identify parameters associated with increased costs.

Results
RS, LS and OS accounted for median daily costs of 1,725 €, 1,633 € and 1,205 €, respectively (p < 0.0001). Median daily (p = 0.420) and total costs (16,648 € vs. 14,578 €, p = 0.076) were comparable between RS and LS. Increased financial expenses for RS were mainly caused by intraoperative costs (7,592 €, p < 0.0001). Length of procedure (hazard ratio [HR] = 5.4, 95% confidence interval [CI] = 1.7–16.9, p = 0.004), length of stay (HR [95% CI] = 8.8 [1.9–41.6], p = 0.006) and development of major complications (HR [95% CI] = 2.9 [1.7–5.1], p < 0.0001) were independently associated with higher costs.

Conclusions
From an economic perspective, RS may be considered a valid alternative to LS for major liver resections.
Effects of cow reproductive status, parity and lactation stage on behaviour and heavy breathing indications of a commercial accelerometer during hot weather conditions
Authors: Leliveld Lisette M.C. , Lovarelli Daniela , Finzi Alberto , Riva Elisabetta , Provolo Giorgio 
Published: May 2023

AbstractHeat stress presents one of the most urgent challenges to modern dairy farming, having major detrimental impacts on cow welfare, health, and production. Understanding the effect of cow factors (reproductive status, parity, and lactation stage) on the physiological and behavioural response to hot weather conditions is essential for the accurate detection and practical application of heat mitigation strategies. To study this, collars with commercial accelerometer-based sensors were fitted on 48 lactation dairy cows to record behaviour and heavy breathing from late spring to late summer. The temperature-humidity index (THI) was calculated from measurements of 8 barn sensors. We found that, above a THI of 84, cows in advanced pregnancy (>90 days) spent more time breathing heavily and less time eating and in low activity than other cows, while cows in early pregnancy (≤90 days) spent less time breathing heavily, more time eating and in low activity. Cows with 3+ lactations showed less time breathing heavily and in high activity and more time ruminating and in low activity than cows with fewer lactations. Although lactation stage interacted significantly with THI on time spent breathing heavily, ruminating, eating, and in low activity, there was no clear indication at which lactation stage cows were more sensitive to heat. These findings show that cow factors affect the cow’s physiological and behavioural response to heat, which could be used to provide group-specific heat abatement strategies, thereby improving heat stress management.
Brain stimulation for chronic pain management: a narrative review of analgesic mechanisms and clinical evidence
Authors: Szymoniuk Michał , Chin Jia-Hsuan , Domagalski Łukasz , Biszewski Mateusz , Jóźwik Katarzyna , Kamieniak Piotr 
Published: May 2023

AbstractChronic pain constitutes one of the most common chronic complaints that people experience. According to the International Association for the Study of Pain, chronic pain is defined as pain that persists or recurs longer than 3 months. Chronic pain has a significant impact on individuals’ well-being and psychosocial health and the economy of healthcare systems as well. Despite the availability of numerous therapeutic modalities, treatment of chronic pain can be challenging. Only about 30% of individuals with non-cancer chronic pain achieve improvement from standard pharmacological treatment. Therefore, numerous therapeutic approaches were proposed as a potential treatment for chronic pain including non-opioid pharmacological agents, nerve blocks, acupuncture, cannabidiol, stem cells, exosomes, and neurostimulation techniques. Although some neurostimulation methods such as spinal cord stimulation were successfully introduced into clinical practice as a therapy for chronic pain, the current evidence for brain stimulation efficacy in the treatment of chronic pain remains unclear. Hence, this narrative literature review aimed to give an up-to-date overview of brain stimulation methods, including deep brain stimulation, motor cortex stimulation, transcranial direct current stimulation, repetitive transcranial magnetic stimulation, cranial electrotherapy stimulation, and reduced impedance non-invasive cortical electrostimulation as a potential treatment for chronic pain.
Comparison of anal function and quality of life after conformal sphincter preservation operation and intersphincteric resection of very low rectal cancer: a multicenter, retrospective, case–control analysis
Authors: Sun G. , Zang Y. , Ding H. , Chen Y. , Groothof D. , Gong H. , Lou Z. , Meng R. , Chen Z. , Furnee E. , Xiang J. , Zhang W. 
Published: May 2023

Abstract
Purpose
Conformal sphincter preservation operation (CSPO) is a sphincter preservation operation for very low rectal cancers. Compared to intersphincteric resection (ISR), CSPO retains more dentate line and distal rectal wall, and also avoids damaging the nerves in the intersphincteric space. This study aimed to compare the postoperative anal function and quality of life between the CSPO and ISR.

Method
Patients with low rectal cancer undergoing CSPO (n = 117) and ISR (n = 66) were included from Changhai and Huashan Hospital, respectively, between 2011 and 2020. A visual analog scale (range 0–10) was utilized to evaluate satisfaction with anal function and quality of life. The anal function was evaluated with Wexner scores and low anterior resection syndrome (LARS) score. Quality of life was evaluated with the EORTC QLQ-C30 and QLQ-CR38.

Results
The CSPO group had more male patients (65.8% vs. 50%, p = 0.042), more preoperative chemoradiotherapy (33.3% vs. 10.6%, p < 0.001), lower tumor position (3.45 ± 1.13 vs. 4.24 ± 0.86 cm, p < 0.001), and more postoperative chemotherapy (65% vs. 13.6%, p < 0.001) compared to the ISR group. In addition, CSPO patients had shorter postoperative stay (6.63 ± 2.53 vs. 7.85 ± 4.73 days, p = 0.003) and comparable stoma reversal rates within 1 year after surgery (92.16% vs. 96.97%, p = 0.318). Multivariable analysis showed that CSPO significantly contributed to higher satisfaction with anal function (beta = 1.752, 95% CI 0.776–2.728) and with quality of life (beta = 1.219, 95% CI 0.374–2.064), but not to Wexner, LARS score, or EORTC QLQ-C30 and QLQ-CR38.

Conclusion
CSPO improved the satisfaction with anal function and quality of life but utilized more preoperative chemoradiotherapy. CSPO may be an alternative choice for patients with very low rectal cancers in better physical health and with higher requirements for anal function and quality of life.
Long-term perturbations in four-body systems with mutual highly inclined orbits
Authors: Monzón C. V. , Docobo J. A. 
Published: May 2023

AbstractHierarchical Three Body systems with mutual highly inclined orbits have been well-known since the 1960s. Lidov-Kozai cycles arise within them where the inner orbit eccentricity acquires extreme values. In particular, we focus our research on the motion of exoplanets and exomoons on different Three Body stellar scenarios. Our goal is to study how the LK cycles are perturbed by a fourth body (which we called perturbed LK). We analyze the evolution of the eccentricity and inclination of the inner orbit in two cases: the first involves an exoplanet and the second involves an exomoon. Due to the possible stable configurations of a four-body system, we treat two subcases as well: the Totally Hierarchical Configuration and the 2 + 2 configuration. According to that derived from the particular scenarios of study discussed in the present research, the LK perturbed in exomoon orbits around exoplanets seem to exhibit, in general, way less alterations than the exoplanet orbit around its star.
Heroines and Mothers: Female Representation in the Carnegie Medal Winners 1936–2020
Authors: Lindahl-Wise Mette 
Published: May 2023

AbstractThis article presents quantitative research into the representations of females in Carnegie Medal-winning books 1936–2020. The relative presence or absence of female protagonists (heroines) and their mothers are used as proxies for gauging whether the representation of females is equitable. The research shows male protagonists outnumber female ones by a ratio of 1.58. Further, adult females are underrepresented in the narratives, as only 42% feature mothers who are alive and present in the story. Mothers are even underrepresented in fictional lone-parent families. While there is a strong correlation between female authors and female characters, the bias against fictional females is pronounced and so pervasive that it may signal a ‘symbolic annihilation’ of females in this particular cultural product. Societal changes and realities appear to have been slow to manifest in the Carnegies and a bias against females has not been attenuated even in recent years. Reflecting the diversity of lived experience in books is essential, and it is imperative that readers, including girls, are offered opportunities for identification—not only with protagonists but also adult females who might serve as role models to help them navigate towards adulthood.
Empowering Green Girls: An Ecofeminist Reading of Baba Yaga and the Black Sunflower and The Girl Who Swallowed a Cactus
Authors: Bayoumy Heidi Mohamed 
Published: May 2023

AbstractTo children, nature is not only the shelter, savior, and life-maintaining force, but also the impressive world that they are involuntarily attracted to. The immense fascination with nature in children’s literature shows the significance of such a relation. This paper seeks to examine two plays for children that deal with the relation between young girls and nature: Baba Yaga and the Black Sunflower (2000) by Carol Korty and The Girl Who Swallowed a Cactus (2020) by Eric Coble. Both plays do not merely highlight the importance of nature and the natural world, but also emphasize the relentless attempts of young girls to protect nature and reconcile with its inhabitants. The protagonists in both plays emerge as the central driving force; they embark on a journey to the natural world in which they find peace, understand the value of nature, and, finally, save the natural and the human world as well. Drawing upon ecofeminism, the paper aims to examine both plays as ecofeminist texts through analyzing the young girls’ perception of the injustice done to the natural world and its dwellers, and their journeys that end with the reconciliation with nature.
Densities of codes of various linearity degrees in translation-invariant metric spaces
Authors: Gruica Anina , Horlemann Anna-Lena , Ravagnani Alberto , Willenborg Nadja 
Published: May 2023

AbstractWe investigate the asymptotic density of error-correcting codes with good distance properties and prescribed linearity degree, including (sub)linear and nonlinear codes. We focus on the general setting of finite translation-invariant metric spaces, and then specialize our results to the Hamming metric, to the rank metric, and to the sum-rank metric. Our results show that the asymptotic density of codes heavily depends on the imposed linearity degree and the chosen metric.
Novel gas exposure system for the controlled exposure of plants to gaseous hydrogen fluoride
Authors: DeMille Katherine F. , Emsbo-Mattingly Stephen D. , Krieger Gary , Howard Michael , Webster Katie B. , DaCosta Michelle 
Published: May 2023

Abstract
Plants can serve as sensitive bioindicators of the presence of contaminant vapors in the atmosphere. This work describes a novel laboratory-based gas exposure system capable of calibrating plants as bioindicators for the detection and delineation of the atmospheric contaminant hydrogen fluoride (HF) as a preparatory step for monitoring release emissions. To evaluate changes in plant phenotype and stress-induced physiological effects attributed to HF alone, the gas exposure chamber must have additional controls to simulate otherwise optimal plant growth conditions including variables such as light intensity, photoperiod, temperature, and irrigation. The exposure system was designed to maintain constant growth conditions during a series of independent experiments that varied between optimal (control) and stressful (HF exposure) conditions. The system was also designed to ensure the safe handling and application of HF. An initial system calibration introduced HF gas into the exposure chamber and monitored HF concentrations by cavity ring-down spectroscopy for a 48-h period. Stable concentrations inside the exposure chamber were observed after approximately 15 h, and losses of HF to the system ranged from 88 to 91%. A model plant species (Festuca arundinacea) was then exposed to HF for 48 h. Visual phenotype stress-induced responses aligned with symptoms reported in the literature for fluoride exposure (tip dieback and discoloration along the dieback transition margin). Fluoride concentrations in exposed tissues compared to control tissues confirmed enhanced fluoride uptake due to HF exposure. The system described herein can be applied to other reactive atmospheric pollutants of interest in support of bioindicator research.