bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of efficacy between canagliflozin and teneligliptin as add-on therapy to metformin and glimepiride on plasma glucose levels along with blood pressure and lipid levels in patients with type 2 diabetes mellitus
Authors: Gautam Ashish , Singh Shoor Vir , Gupta Ankit , Sharma Anupam , Gupta Saurabh , Pursnani Nikhil , Agrawal Prabhat 
Published: August 2023

Abstract

Background:
Despite of several guidelines metformin and glimepiride remains the first prescribed drug in most people with diabetes. Very often canagliflozin and teneligliptin remain the third prescribed OHA. Efficacy of teneligliptin and canagliflozin as solo drug or in combination with other single OHA’s on glycaemic parameters, lipid profiles & blood pressure is already established. But their efficacy on above parameters when used as third drug next to metformin and sulfonylurea is still not investigated.

Aims and objectives:
Aim of this study is to compare glycaemic and non-glycemic effects of canagliflozin and teneligliptin as third line drug. Objective is to establish their multiple pleotropic effects at this position.

Methods:
Subjects with uncontrolled glycaemic parameters with hypertension and diabetic dyslipidaemia already on half maximal doses of metformin and glimepiride were enrolled in the study. Out of 87 selections, 45 were prescribed canagliflozin 100 mg/d and to 42 subjects, teneligliptin 20mg/d, each for 24 weeks. Effects over HbA1c, fasting and post prandial plasma glucose, systolic and diastolic blood pressures, HDL’c and triglycerides were observed pre and post intervention.

Results:
As a third drug both canagliflozin and teneligliptin show significant reduction in HbA1c (1.5 versus 1.6%), fasting (-20.2 versus -28.8 mg %), and post prandial (-39.9 versus – 58.5mg %). Effects over systolic (4 mmHg versus 1.1 mmHg) and diastolic BP (3.1 mmHg versus 0.2 mmHg) was clinically and statistically significant (p = 0.3 and 0.1) respectively in both groups. A statistically insignificant (9.6 versus 4.1 mg%; p =) reduction in Triglycerides but significant (7.6 versus 1.2; p <0.0001) increase in HDL’c was observed.

Conclusion:
Canagliflozin and teneligliptin, both retains their glycaemic and non-glycaemic benefits even when used as third OHA for diabetes management. Canagliflozin scores better for comorbid hypertension and diabetic dyslipidaemia.
Cavernosal abscess and primary scrotal calcinosis in the diabetic patient: A case report and review of literature
Authors: Pandiaraja Jayabal 
Published: August 2023

Abstract
A cavernosal abscess is a rare urological condition to occur. It is classified as primary and secondary. The primary is mostly idiopathic, whereas the secondary is associated with some precipitating factors. Most of the cases were diagnosed clinically. In some cases, imaging such as an ultrasound of the local region or magnetic resonance imaging may be required. Cavernosal abscesses can be treated using a minimally invasive procedure such as image-guided drainage or incision and drainage along with systemic antibiotics. A 52-year-old uncircumscribed uncontrolled diabetic patient presented with a complaint of swelling in the penile region for the 1-week duration. He also complains of pain in the penile region for a 5-day duration. He is a known case of type 2 diabetes on oral hypoglycemic drugs for the past 2 years. Clinical examination confirmed the diagnosis of cavernosal abscess. The patient underwent circumcision with incision and drainage of abscess under higher antibiotic coverage (vancomycin and metronidazole). The patient underwent local excision of primary scrotal calcinosis after 1 month. The patient is followed up for more than 2 years without any evidence of recurrence or impotence. The cavernosal abscess is one of the rare urological conditions, which needs immediate surgical intervention to reduce future complications such as erectile dysfunction and recurrent abscess. Uncontrolled diabetes has a high chance of developing cavernosal abscesses even without precipitating factors.
An update on the role of antihyperglycemic agents in diabetoporosis
Authors: Sharma Nidhi , Nayak Amit Kumar 
Published: August 2023

Abstract
Diabetes mellitus is a chronic disorder that progresses globally at an alarming rate. The impact of this disorder is severe as it deteriorates the quality of life due to its associated diseases such as kidney disease, cardiovascular disease, obesity, and neurological disorders and also disturbs bone metabolism. One of the major complications of diabetes is osteoporosis, which is frequently brought on by diabetes. Bone abnormalities and a higher risk of fractures are linked to both type type-1 diabetes and type-2 diabetes and hence diabetes is regarded as one of the risk factors for the occurrence of osteoporosis. In view of this, there is a need to assess the therapeutic role of hypoglycemic agents in the treatment of osteoporosis. Glucagon-like peptide-1 (GLP-1) agonist, a hypoglycemic class could be a novel and promising drug target in the management of osteoporosis due to its additional role in the bone remodeling process. It has also been reported that GLP-1 agonists can increase bone mineral density, improve bone quality, and prevent fractures in diabetic patients. This review highlights the recent findings by which antidiabetic medications are used in the treatment of diabetes-induced osteoporosis and also gives an insight into its pathophysiology and possible mechanisms that are involved in the treatment of diabetes-induced osteoporosis. However, more research is required to fully understand the therapeutic role and unique mechanism of GLP-1 agonists in the bone remodeling process.
A qualitative study on the perceived benefits of back to basics-diabesties session among individuals with type 1 diabetes mellitus and caregivers in India
Authors: Sethi Jazz , Natarajan Lakshmi , Dev Deeksha , Kothapalli Sanjana R , Dhagia Sumeet , Mohan Viswanathan , Subrahmanyam Ayyalasomayajula S , Bhale Yash , Shah Hetansh S , Bommathula AnuHasini , Aravindakshan Pramodkumar T 
Published: August 2023

Abstract

Aim:
Type 1 diabetes mellitus (T1DM) is a chronic metabolic disorder that makes self-care challenging for T1DM individuals and their caregivers. This qualitative study aimed to explore the perceived benefits of the Back to Basics-Diabesties (B2B) session among T1DM individuals and their caregivers in India.

Materials and Methods:
The B2B session is a structured intervention provided through telephonic peer counseling, aimed at enhancing the understanding of T1DM that provides practical knowledge of diabetes management, insulin administration, blood glucose monitoring, diet, exercise, and psychosocial aspects of living with T1DM. Overall, more than 1560 participants (T1DM/caregivers/family/friends) have opted for B2B session. A qualitative telephonic interview was conducted (n = 96) using a semistructured open-ended questionnaire to collect data on the perceived benefits of B2B session. The information obtained was then coded, and grouped to form themes.

Results:
According to T1DM individuals, B2B sessions enhanced diabetes knowledge and confidence, self-management abilities, increased sense of community and peer support, and easy accessibility. Caregivers reported that the B2B session provided emotional support, disease knowledge, shared experiences, practical ideas, and coping strategies. Most widely appreciated salient feature of B2B session was the peer counselors were themselves with T1DM or caregivers of T1DM, which created unbreakable trust among the study participants. Clinical evidence after B2B session showed a 23% of improvement in the glycated hemoglobin (<8%) and nearly 8% of drop in hypoglycemic events and 17% of drop in hyperglycemic episodes.

Conclusion:
This study shows the benefits of peer counseling, which could help healthcare professionals and policymakers improve diabetes education and support programs for T1DM patients and their caregivers in India.
Case Report: Hemophagocytic Lymphohistiocytosis Secondary to Plasmodium ovale wallikeri Infection
Authors: Novella-Mena María , Cantudo-Muñoz Purificación , Tallón-Pérez José David , Gómez-Rodríguez María del Mar , Rojo-Marcos Gerardo 
Published: August 2023

ABSTRACT.
We report the first known case of hemophagocytic lymphohistiocytosis (HLH) secondary to imported Plasmodium ovale wallikeri infection in a 58-year-old white woman. A delayed diagnosis of malaria and HLH was made after protracted fever and pancytopenia failed to respond adequately to antimalarial treatment, which required intravenous methylprednisolone and gamma-globulin therapy to resolve.
ANALISIS PENERAPAN METODE MONTESSORI PADA ASPEK KEMANDIRIAN ANAK MELALUI KEGIATAN PEMBELAJARAN PRACTICAL LIFE
Authors: Kamil Nurhusni , Asriyani Solatiyah 
Published: August 2023

Sikap mandiri merupakan suatu hal yang paling mendasar yang perlu diterapkan kepada anak usia dini dari orang dewasa. Penanaman sikap kemandirian kepada anak dapat dilakukan melalui berbagai kegiatan dan hal yang sangat disukai oleh anak. Ada banyak cara dan metode yang digunakan salah satunya melalui penerapan metode Montessori melalui kegiatan practical life. Kegiatan pembelajaran ini bermaksud mengajarkan anak tentang aspek kemandirian melalui hal-hal sederhana dalam hidupnya. Metode penelitian yang digunakan dalam bentuk kualitatif dengan menggunakan tinajuan pustaka (library research). Adapun tujuan dari penelitian ini adalah untuk mengetahui analisis penerapan metode Montessori pada aspek kemandirian anak melalui kegaiatan pembelajaran paractical life. Temuan baru dalam penelitian ini adalah informasi kepada semua orang tua dan guru sebagai praktisi PAUD.
STRATEGI MANAJEMEN KELAS PEMBELAJARAN PENGUCAPAN KATA DALAM BAHASA INGGRIS PADA PESERTA DIDIK USIA DINI DI TK AL FITIYAN ACEH BESAR
Authors: Sariakin  , Faizah Cut , Fitria Nora 
Published: August 2023

Penelitian ini bertujuan: (1) untuk mengkaji bagaimana guru TK Alfitiyan menyiapkan strategi manajemen kelas pada proses bembelajaran pengucapan, (2) untuk mengkaji bagaimana guru TK Al fitiyan melakukan strategi manajemen kelas dalam proses pembelajaran pengucapan, dan (3) untuk mengkaji bagaimana guru TK Al fitiyan mengevaluasi hasil strategi manajemen kelas dalam proses pembelajaran pengucapan. Penelitian ini termasuk penelitian kualitatif karena hanya menggambarkan situasi dan kondisi pelaksanaan proses pembelajaran pengucapan hanya dua orang maka guru tersebut diambil sebagai subyek penelitian dan dinamakan sumber data. Instrumen yang digunakan untuk mengumpulkan data adalah observasi, wawancara, dan dokumentasi. Data yang diperoleh dianalisis dengan prosedur narasi. Hasil kajian menunjukkan bahwa guru menyiapkan silabus dan bahan ajar persemeter. Guru menggunakan satu metode dalam proses belajar mengajar metode latihan. Selanjutnya dalam mengevaluasi hasil proses belajar mengajar, guru mengevaluasi peserta didik dengan menggunakan satu macam tes yaitu tes proses berjalan. Tes yang dilakukan berupa secara individual. Berdasarkan hasil penelitian dalam proses belajar mengajar, guru harus menekankan pengajaran cara atau metode yang cukup sesuai untuk tingkat siswa dalam belajar pengucapan.
MODEL PEMBELAJARAN IMPROVE UNTUK MENINGKATKAN KEMAMPUAN REFLEKTIF MATEMATIS SISWA SMA
Authors: Junaidi  , Taufiq  
Published: August 2023

Penelitian ini bertujuan untuk mengetahui apakah kemampuan reflektif matematis siswa dapat ditingkatkan melalui penggunaan model pembelajaran IMPROVE. Sampel penelitian ini adalah kelas X MIA 1 dan X MIA 2 di SMA Negeri 1 Geumpang. Soal essay tentang materi sistem persamaan linear tiga variabel digunakan sebagai materi pendukung penelitian. Peneliti menggunakan penelitian eksperimen untuk merancang soal Pretest-Posttest Control Group Design. Uji normalitas dan homogenitas data dengan taraf signifikansi 5% secara statistik digunakan untuk memverifikasi data. Dari hasil analisis data diketahui rata-rata n-gain kelas eksperimen untuk meningkatkan kemampuan reflektif matematis siswa adalah 74,44 dan n-gain kelas kontrol adalah sebanyak 68,07, sehingga dapat disimpulkan kemampuan reflektif matematis siswa yang diajarkan melalui metode IMPROVE dapat meningkat dibandingkan dengan pembelajaran konvensional. Penelitian ini dapat merekomendasikan penggunaan pembelajaran IMPROVE sebagai metode pembelajaran yang dapat digunakan di kelas.
Pengaruh Model Pembelajaran Tipe Team Asisted Individualization (TAI) Terhadap Hasil Belajar Siswa Pada Mata Pelajaran PPKn Di SMP Negeri 20 Pekanbaru
Authors: Sesie dartika Sesie , Supentri  , Hardian Mirza 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran team assisted
individualization terhadap hasil belajar siswa pada mata pelajaran PPKn di SMP Negeri 20 Pekanbaru. Pada penelitian ini dalam proses pembelajaran peneliti sebagai pengajar. Penelitian ini termasuk jenis penelitian eksperimen dengan desain penelitian Pretest- Posttest Control Group Design. Subjek penelitian ini adalah siswa kelas VIII SMP Negeri 20 Pekanbaru. Objek penelitian ini adalah pengaruh model pembelajaran team assisted individualization terhadap hasil belajar siswa pada mata pelajaran PPKn dengan materi memahami kedudukan dan fungsi pancasila. Populasi dalam penelitian ini adalah
seluruh siswa kelas VIII SMP Negeri 20 Pekanbaru. Sampel dalam penelitian ini adalah 80 orang siswa dari kelas VIII-8 dan VIII-9. Teknik pengumpulan data dalam penelitian ini adalah tes dan dokumentasi. Nilai rata-rata kelas eksperimen adalah 80,75 dan kelas kontrol adalah 70,50. Teknik analisis data dalam penelitian ini adalah uji normalitas dan uji t. Dimana untuk melihat hasil belajar siswa dilakukan uji t yang menunjukkan nilai thitung ˃ ttabel (2,858 ˃ 1,990) maka dapat disimpulkan bahwa ha diterima dan h0 ditolak yang menjelaskan bahwa terdapat pengaruh model pembelajaran team assisted ndividualization terhadap hasil belajar siswa. Hal ini dikarenakan siswa belajar menggunakan model pembelajaran team assisted individualization.
Kata Kunci: Pembelajaran, Team Asisted Individualization, Hasil Belajar
PENGAWASAN KEKERASAN DALAM DUNIA PENDIDIKAN UNTUK MENINGKATKAN MUTU SEKOLAH DASAR ACEH BESAR
Authors: Akmaluddin  , Rahmattullah  
Published: August 2023

Fenomena kekerasan di lingkungan sekolah baru-baru ini menjalani tinjauan intensif publisitas. berdasarkan data yang dirilis Komisi Perlindungan Anak Indonesia (KPAI) tahun 2017, menurut survei International Center for Research on Women (ICRW), sebanyak 84% anak di Indonesia mengalami kekerasan di sekolah. Angka kasus kekerasan di sekolah di Indonesia ini lebih tinggi dari Vietnam 79% , Nepal 79%, Kamboja 73%, dan Pakistan 43%. Metode penelitian ini merupakan penelitian kuantitatif deskriptif dengan jenis penelitian survey. Sampel penelitian ini dua sekolah dasar di kabupaten Aceh Besar yaitu SD Negeri 1 Lamcot dan SD Negeri 2 Lamcot. Mengumpulkan informasi factual menggunakan kuesioner dan wawancara. Kuesioner berisikan 12 aspek, untuk mengukur pengawasan kekerasan diperoleh berdasarkan hasil kuesioner responden. Pada SD Negeri 1 Lamcot memperoleh rata-rata 4,35 sedangkan di SD Negeri 2 Lamcot meraih rata-rata 4,30. Hasil tersebut diperoleh melalui kuesioner yang berisikan 12 item indicator yang bagikan pada responden. Penelitian menggunakan teknik wawancara tentang pengawasan kekerasan dalam pendidikan meraih respon positif.
Mathematics Online Baseline Assessment: Senior Phase First-year Student Teachers’ Views
Authors: Adelabu Folake Modupe , Alex Jogmol Kalariparampil 
Published: August 2023

Problem-solving and enquiry-based learning are integral in the Mathematics and Science curriculum in South Africa through online-based assessment. Online assessment has rapidly gained recognition because of technology. In this paper, the authors explored the views of online baseline assessment among Senior Phase First-year Mathematics Student Teachers. The researchers adopted a qualitative research method. Data was collected from the participants using an online Google form developed into a questionnaire. The participants in this study were first-year students enrolled for the Bachelor of Education in Mathematics at a university in a rural province of South Africa. The first-year student teachers were exposed to the senior phase baseline assessments through the licensed online Computer Aided Mathematics Instruction (CAMI) tool. One hundred and sixteen (116) senior-phase student teachers completed the online questionnaire. This study used convenience sampling since it was the most appropriate method to conveniently invite the participant. The findings revealed that first-year student teachers were enthusiastic and motivated to write the baseline assessment on computers for the first time. The result also showed that several first-year student teachers experienced difficulties solving mathematics problems using computers. This study recommends more intensive research on student teachers' views on online assessment regarding gender and time.
The bird assemblage of an urban fragment of the Atlantic Forest in Northeastern Brazil, and the performance difference between two ornithological surveys methods
Authors: Oliveira-Silva Williams , Guedes Tainá Karoline , Oliveira Priscilla Monteiro de , Lyra-Neves Rachel Maria De , Telino-Junior Wallace Rodrigues , Gaban-Lima Renato 
Published: August 2023

The Atlantic Forest biome encompasses a major portion of Brazilian biodiversity, with a high species richness. The Pernambuco Center of Endemism, which is part of this biome, has undergone extensive deforestation, and now survives in the form of small and isolated remnants of the original forest cover. These remnants include Maceió Municipal Park, an important urban forest in the capital of Alagoas. The present study inventoried the bird fauna of this conservation unit, providing data on species composition, richness, and abundance, with samples being collected monthly between August 2014 and January 2016. Quantitative data were collected using MacKinnon list and point counts. A total of 103 bird species were recorded. Five of these species are endemic to the Pernambuco Center and two to the Atlantic Forest, while four are listed under some threat of extinction. The results indicated that the MacKinnon lists present better efficiency to obtainspecies richness, while point counts present the best performance for abundance estimates. Our findings also indicate that Maceió Municipal Park is a potentially important refuge for the local bird fauna. The presence of threatened and endemic taxa highlights the relevance of the study area for the conservation of the region’s biodiversity.
TRAUMATISMO ANO RECTAL CONTUSO
Authors: Naranjo Cardenas Dayana 
Published: August 2023

Introducción: El traumatismo ano rectal es una causa poco frecuente de consulta al servicio de emergencias; en la literatura reportan una incidencia del 1% al 3 %. A menudo están asociadas a lesiones potencialmente mortales; por esta razón es fundamental conocer los principios de diagnóstico y tratamiento, así como, los protocolos de atención inicial de pacientes politraumatizados.
Método: Reportamos un caso de un paciente masculino de 47 años con trauma anorectal contuso con compromiso de esfínter anal interno y externo.
Se realiza reparación primaria con técnica overlapping, proctorrafia de mucosa, submucosa y muscular de conducto anal.
Con seguimiento a los 12 meses, con buena evolución sin incontinencia anorrectal
Conclusión: El tratamiento del trauma rectal, con la experiencia en base al dogma de las 4 D (desbridamiento, derivación fecal, drenaje presacro, lavado distal), en lesiones de recto extraperitoneal se ha convertido en elección.
Palabras claves: Traumatismo anal, Traumatismo anorrectal, lesión traumática de esfínter anal.
Assessment of Aflatoxin Contamination in Maize and Groundnuts during Storage in Giwa Community, Kaduna State Nigeria
Authors: Abdurrazaq, M.  , Tijjani, M.B  , Atta, H.I.  
Published: August 2023

Contamination of food and feed by aflatoxins has become a worldwide cause of public health concern due to its significant impact on human health and crop market value. The present study aimed to assess the aflatoxin contents of maize and groundnut from stores and warehouses in the Giwa community, Kaduna State, Nigeria. A total of ninety (90) grain samples of maize and groundnut were collected between October to December 2020 and analyzed for total aflatoxins using Enzyme-Linked Immuno Sorbent Assay (ELISA). Eighty-four 84(93.3%) of the samples had detectable aflatoxin levels (0.2-9.8ppb), while six 6(6.7%) had none. There was no significant difference (P>0.05) in the mean total aflatoxin content of the grains from stores, warehouses and household foodstuff samples. This could be attributed to agricultural practices and low temperature and humidity storage conditions, which were the same for all the stored grains. Overall, aflatoxin concentrations of the grain samples were within the acceptable limit (10ppb for maize and 15ppb for groundnut) for food safety set by NAFDAC. However, there could be further contamination during storage, particularly when temperature rises and humidity increases. Hence, improved storage conditions and monitoring of grain before sale are recommended to avoid contamination during storage and to ensure a healthy and safe food supply along the trade chain and to the consumers.
Antibacterial Activity of some Antibiotics and Disinfectants against Airborne Bacteria Isolated from Restaurants in Yola
Authors: K. I. Chimbekujwo  , S. A. Ya’u  , R. D. Raskeb  
Published: August 2023

The aim of this study was to determine the antibacterial activity of some antibiotic and disinfectant against airborne bacteria from restaurants. Airborne bacteria were isolated from five different restaurants using open plate method and were characterized using standard microbiological techniques. The susceptibility of the isolates to some antibiotics and disinfectants was determined using Kirby-Bauer disc diffusion method and well diffusion. The predominant bacteria identified in the air of the restaurants were S. aureus 9 (45%), Micrococcus spp. 5 (25%), Bacillus subtilis 4 (20 %) and P. aeruginosa 2 (10 %). The results showed that the highest and lowest average densities of bacteria for both morning and afternoon release were for 71 and 86 CFU/ m3 and 37 and 46 CFU / m3 respectively. Antimicrobial susceptibility test results revealed that S. aureus was susceptible to Ciprofloxaxin (88.9%), Ampiclox (66.7%), Amoxicillin (66.7%), Rocephin (55.6%) and Gentamycin (55.6%), but resistant to streptomycin and erythromycin. Micrococcus spp was susceptible to Pefloxacin (60%), Erythromycin (100%), Ciprofloxacin (100%), and Streptomycin (80%), but were resistance to Gentamycin, Zinnacet, and Co-trimoxazole. Bacillus subtillis were susceptible to Amoxicillin 4 (100 %), Pefloxacin, Gentamycin, Streptomycin and Ampiclox (50 %), and Zinnacet (75 %), but were resistance to Rocephin, Erythromycin and Co-trimoxazole. P. aeruginosa were susceptible to Ciprofloxacin (100%) and Augmentin (50%) but resistant to Gentamycin, Pefloxacin, ofloxacin, streptomycin, Chloramphenicol, Co-trimoxazole, Sparfloxacin, Amoxicilin and Rocephin. All the bacteria species showed multiple drug resistance. Disinfectants (Hypo and Dettol) showed antibacterial activity with varying magnitudes (50-100% concentrations but showed no efficacy at concentrations lower than 25%. The study identifies the presence of potentially pathogenic bacteria in the air of restaurants with varying degree of antimicrobial susceptibilities which may pose a serious health hazard to both students and workers.