bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying sources of human interictal discharges with travelling wave and white matter propagation
Authors: Withers C Price , Diamond Joshua M , Yang Braden , Snyder Kathryn , Abdollahi Shervin , Sarlls Joelle , Chapeton Julio I , Theodore William H , Zaghloul Kareem A , Inati Sara K 
Published: August 2023

Abstract
Interictal epileptiform discharges have been shown to propagate from focal epileptogenic sources as travelling waves or through more rapid white matter conduction. We hypothesize that both modes of propagation are necessary to explain interictal discharge timing delays. We propose a method that, for the first time, incorporates both propagation modes to identify unique potential sources of interictal activity.
We retrospectively analysed 38 focal epilepsy patients who underwent intracranial EEG recordings and diffusion-weighted imaging for epilepsy surgery evaluation. Interictal discharges were detected and localized to the most likely source based on relative delays in time of arrival across electrodes, incorporating travelling waves and white matter propagation. We assessed the influence of white matter propagation on distance of spread, timing and clinical interpretation of interictal activity. To evaluate accuracy, we compared our source localization results to earliest spiking regions to predict seizure outcomes.
White matter propagation helps to explain the timing delays observed in interictal discharge sequences, underlying rapid and distant propagation. Sources identified based on differences in time of receipt of interictal discharges are often distinct from the leading electrode location. Receipt of activity propagating rapidly via white matter can occur earlier than more local activity propagating via slower cortical travelling waves. In our cohort, our source localization approach was more accurate in predicting seizure outcomes than the leading electrode location. Inclusion of white matter in addition to travelling wave propagation in our model of discharge spread did not improve overall accuracy but allowed for identification of unique and at times distant potential sources of activity, particularly in patients with persistent postoperative seizures.
Since distant white matter propagation can occur more rapidly than local travelling wave propagation, combined modes of propagation within an interictal discharge sequence can decouple the commonly assumed relationship between spike timing and distance from the source. Our findings thus highlight the clinical importance of recognizing the presence of dual modes of propagation during interictal discharges, as this may be a cause of clinical mislocalization.
Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies
Authors: Chopra Avika , Outeiro Tiago Fleming 
Published: August 2023

Abstract
Parkinson’s disease is clinically known for the loss of dopaminergic neurons in the substantia nigra pars compacta and accumulation of intraneuronal cytoplasmic inclusions rich in alpha-synuclein called ‘Lewy bodies’ and ‘Lewy neurites’. Together with dementia with Lewy bodies and multiple system atrophy, Parkinson’s disease is part of a group of disorders called synucleinopathies. Currently, diagnosis of synucleinopathies is based on the clinical assessment which often takes place in advanced disease stages. While the causal role of alpha-synuclein aggregates in these disorders is still debatable, measuring the levels, types or seeding properties of different alpha-synuclein species hold great promise as biomarkers.
Recent studies indicate significant differences in peptide, protein and RNA levels in blood samples from patients with Parkinson’s disease. Seed amplification assays using CSF, blood, skin biopsy, olfactory swab samples show great promise for detecting synucleinopathies and even for discriminating between different synucleinopathies. Interestingly, small extracellular vesicles, such as exosomes, display differences in their cargoes in Parkinson’s disease patients versus controls.
In this update, we focus on alpha-synuclein aggregation and possible sources of disease-related species released in extracellular vesicles, which promise to revolutionize the diagnosis and the monitoring of disease progression.
Economic Preferences and Personality Traits Among Finance Professionals and the General Population
Authors: Holmén Martin , Holzmeister Felix , Kirchler Michael , Stefan Matthias , Wengström Erik 
Published: August 2023

Abstract
Based on artefactual field experiments, we investigate whether finance professionals differ from a sample of the working population in terms of industry-relevant preferences and personality traits. When adjusting for socioeconomic characteristics, we find only few and less marked differences: finance professionals are less risk averse, less trustworthy, show higher levels of psychopathy and are more competitive than participants from the general population. In an additional survey, experts with hiring experience consider industry selection, self-selection and imprinting by industry norms as explanatory for the observed subject pool differences.
Functional Decline Over Time and Change in Family and Other Unpaid Care Provided to Community-Dwelling Older Adults Living With and Without Dementia
Authors: Lei Lianlian , Maust Donovan T , Leggett Amanda N 
Published: August 2023

Abstract

Objectives
To provide a longitudinal analysis of how functional decline over time among older adults affects provision of family and unpaid care, overall and stratified by dementia status.

Methods
Longitudinal cohorts of community-dwelling adults ≥65 years between 2015 and 2017 from the National Health and Aging Trends Study (NHATS; n = 5,103) and their caregivers from the National Study of Caregiving (n = 862 caregivers for 595 NHATS care recipients). A panel data fixed-effects model was used to examine how increases in mobility, self-care, and household activity-related impairment between 2015 and 2017 affected family and unpaid care (care recipient reported: total number of family and unpaid caregivers, total hours of care received; caregiver reported: hours of care provided, caregiving-related emotional, and physical difficulties).

Results
Among community-dwelling older adults overall, impairment in 1 additional self-care activity led to 0.12 more caregivers and 19 additional total monthly hours of care. Among those with dementia, impairment in 1 additional self-care activity led to 0.14 more caregivers and 28 additional total monthly hours of care; among those without dementia, this was 0.11 caregivers and 15 total monthly hours of care. For dementia caregivers, impairment in 1 additional self-care activity among their care recipients led to 8% higher probability of caregiving-related emotional difficulty.

Discussion
There is a mismatch between the large additional hours of care received by older adults who experience functional decline (particularly self-care activities) and the relatively small accompanying increase in family and unpaid caregivers. Targeted functional supports, particularly for self-care activities, may benefit both older adults and their caregivers.
Measuring Age-Friendliness of Transportation and Mobility Characteristics in Communities: A Scoping Review
Authors: Hansmann Kellia J , Deemer David A , Robert Stephanie 
Published: August 2023

Abstract

Background and Objectives
Age-friendly communities are those with characteristics that can support and promote healthy aging. Among the common domains of these characteristics, transportation and neighborhood spaces are particularly relevant for older adults maintaining mobility in their communities. The objective of this scoping review is to provide a synthesis of age-friendly community indicators, developed for research and planning, that evaluate characteristics most associated with community-level mobility, specifically transportation and neighborhood spaces.

Research Design and Methods
We conducted a systematic search of PubMed, Scopus, Medline, APA PsychInfo, CINAHL Plus, SocIndex, Academic Search Premier, and Web of Science. We reviewed 8 articles and reports that described the development or evaluation of a set of generalizable indicators to measure the age-friendliness of a community’s transportation and neighborhood spaces resources.

Results
Indicators of transportation and neighborhood spaces ranged from self-reported measures of accessibility and convenience to objective measures of the availability and cost of services. Explicit discussion of mobility at the community level was variable in these records, and few authors specifically discussed common life transitions impacted by these age-friendly community indicators, such as driving cessation.

Discussion and Implications
Although age-friendly communities are a well-established goal for promoting healthy aging, our review found few validated approaches for measuring age-friendliness that researchers and communities can use to investigate mobility at the community level. This is an important gap in studying life transitions such as driving cessation. Further research can provide a better understanding of which community characteristics support ongoing mobility.
Impact of the solid Earth mass adjustment by the 2011 Tohoku–Oki earthquake on the regional sea level and hydrological mass change recovery from GRACE
Authors: Jeon Taehwan , Seo Ki-Weon , Han Shin-Chan 
Published: August 2023

SUMMARY
For more than a decade, GRACE data have provided global mass redistribution measurements due to water cycles, climate change and giant earthquake events. Large earthquakes can yield gravity changes over thousands of kilometres from the epicentre for years to decades, and those solid Earth deformation signals can introduce significant biases in the estimate of regional-scale water and ice mass changes around the epicentres. We suggest a modelling scheme to understand their contribution to the estimates of water and ice mass changes and to remove the earthquake-related solid mass signals from GRACE data. This approach is composed of physics-based earthquake modelling, GRACE data correction and high-resolution surface mass change recovery. In this study, we examined the case of the 2011 Tohoku–Oki earthquake to better estimate the regional sea level and hydrological mass changes in the East Asia. The co- and post-seismic changes from GRACE observations were used to constrain the earthquake model parameters to obtain optimal self-consistent models for the earthquake source and the asthenosphere rheology. The result demonstrated that our earthquake correction model significantly reduced the mass change signals by solid Earth deformation from the time-series of regional surface mass changes on both land and oceans. For example, the apparent climate-related ocean mass increase over the East Sea was 1.59 ± 0.11 mm yr−1 for 2003–2016, significantly lower than the global mean ocean mass trend (2.04 ± 0.10 mm yr−1) due to contamination of the earthquake signals. After accounting for the solid mass changes by the earthquake, the estimate was revised to 1.87 ± 0.11 mm yr−1, that is increased by 20 per cent and insignificantly different from the global estimate.
Decolonizing Equality—The Legacies of Anti-Colonial Struggles at International Labour Conferences, 1920–1940
Authors: Davy Ulrike 
Published: August 2023

Abstract
The article focuses on the critical moment when the idea of equality entered international law. The article argues that a political claim to equality of all human beings surfaced at the international level already in the 1920s and 1930s, long before human rights were discussed at the United Nations. The International Labour Organisation (ILO), established in 1919, provided the venue for delegates from non-European countries or territories—most of them confronting some form of colonialism—to raise their voices against the exploitation of labour in India, China and other places under the domination of colonial powers. The delegates’ idea of equality was present in arguments attacking racial hierarchies and in arguments criticizing unequal treatment in ‘native labour’ relations. The universalistic idea of the equal worth of all human beings and the idea of equal treatment was advanced to de-legitimize narrow concepts of equality based on race.
A survey of the adoption and perception of mobile health applications among community pharmacists in Malaysia
Authors: Ng Hui Leng , Sellappans Renukha , Loo Jason S E 
Published: August 2023

Abstract

Objectives
To determine the adoption and perception of mobile health (mHealth) applications among community pharmacists in Malaysia.

Methods
A cross-sectional survey using a self-administered questionnaire was conducted with 300 community pharmacists in the Klang Valley, Malaysia using a stratified sampling approach. The questionnaire consisted of 36 questions with three sections: demographic data, adoption of mHealth applications and perception towards mHealth applications. Descriptive and inferential tests as well as exploratory factor analysis were used to analyse the data.

Key findings
Adoption of mHealth applications by community pharmacists for both professional and personal use was relatively high at 79.7%. Utilised mHealth applications were primarily from the medical references category, while applications for patient monitoring, personal care and fitness were used to a lesser degree. Among mHealth application users, only 65.7% recommended them to their patients. Overall perception towards mHealth applications was positive, but perception towards the benefits and favour of mHealth applications for their patients was lower. This was corroborated by the factor analysis, which identified four main factors explaining 59.9% of variance in the dataset. These factors were perception towards use in their own professional practice, perception on benefits and use in their patients, perception on specific features of mHealth applications, and reliability of mHealth applications.

Conclusions
Adoption of mHealth applications among community pharmacists in Malaysia is high. Community pharmacists are more likely to use mHealth applications professionally and personally but less likely to recommend them to patients due to less favourable perceptions on how patients will benefit from mHealth applications.
Assessing the conversion of electronic medical record data into antibiotic stewardship indicators
Authors: Renggli L , Plüss-Suard C , Gasser M , Sonderegger B , Kronenberg A 
Published: August 2023

Abstract

Background
Measuring the appropriateness of antibiotic use is crucial for antibiotic stewardship (ABS) programmes to identify targets for interventions.

Objectives
To assess the technical feasibility of converting electronic medical record (EMR) data into ABS indicators.

Methods
In this observational feasibility study covering a period of 2 years, the EMRs of patients hospitalized at a large non-university hospital network and receiving at least one dose of a systemic antibiotic were included. ABS indicators measuring steps in the process of antibiotic prescription proposed by the literature were collected and rephrased or defined more specifically to be calculable if needed. Algorithms were programmed in R to convert EMR data into ABS indicators. The indicators were visualized in an interactive dashboard and the plausibility of each output value was assessed.

Results
In total, data from 25 337 hospitalizations from 20 723 individual patients were analysed and visualized in an interactive dashboard. Algorithms could be programmed to compute 89% (25/28) of all pre-selected indicators assessing treatment decisions automatically out of EMR data, with good data quality for 46% (13/28) of these indicators. According to the data quality observed, the most important issues were (i) missing or meaningless information on indication (e.g. ‘mild infection’) and (ii) data processing issues such as insufficiently categorized metadata.

Conclusions
The calculation of indicators assessing treatment decisions from EMRs was feasible. However, better data structure and processing within EMR systems are crucial for improving the validity of the results.
Phenotypic and genotypic analysis of antimicrobial resistance inNocardiaspecies
Authors: Hershko Yizhak , Levytskyi Katia , Rannon Ella , Assous Marc V , Ken-Dror Shifra , Amit Sharon , Ben-Zvi Haim , Sagi Orli , Schwartz Orna , Sorek Nadav , Szwarcwort Moran , Barkan Daniel , Burstein David , Adler Amos 
Published: August 2023

AbstractBackgroundAntimicrobial resistance is common in Nocardia species but data regarding the molecular mechanisms beyond their resistance traits are limited. Our study aimed to determine the species distribution, the antimicrobial susceptibility profiles, and investigate the associations between the resistance traits and their genotypic determinants.MethodsThe study included 138 clinical strains of Nocardia from nine Israeli microbiology laboratories. MIC values of 12 antimicrobial agents were determined using broth microdilution. WGS was performed on 129 isolates of the eight predominant species. Bioinformatic analysis included phylogeny and determination of antimicrobial resistance genes and mutations.ResultsAmong the isolates, Nocardia cyriacigeorgica was the most common species (36%), followed by Nocardia farcinica (16%), Nocardia wallacei (13%), Nocardia abscessus (9%) and Nocardia brasiliensis (8%). Linezolid was active against all isolates, followed by trimethoprim/sulfamethoxazole (93%) and amikacin (91%). Resistance to other antibiotics was species-specific, often associated with the presence of resistance genes or mutations: (1) aph(2″) in N. farcinica and N. wallacei (resistance to tobramycin); (ii) blaAST-1 in N. cyriacigeorgica and Nocardia neocaledoniensis (resistance to amoxicillin/clavulanate); (iii) blaFAR-1 in N. farcinica (resistance to ceftriaxone); (iv) Ser83Ala substitution in the gyrA gene in four species (resistance to ciprofloxacin); and (v) the 16S rRNA m1A1408 methyltransferase in N. wallacei isolates (correlating with amikacin resistance).ConclusionsOur study provides a comprehensive understanding of Nocardia species diversity, antibiotic resistance patterns, and the molecular basis of antimicrobial resistance. Resistance appears to follow species-related patterns, suggesting a lesser role for de novo evolution or transmission of antimicrobial resistance.
Implementation of the first comprehensive state oral fluid drug testing program for roadside screening and laboratory testing in DUID cases—A 5-year review
Authors: Harper Curt E , Hudson Jason S , Tidwell Kristin , Boswell Rebekah , Yong Hui Liu , Maxwell Antoinette J 
Published: August 2023

Abstract
Oral fluid (OF) is a valuable specimen for driving under the influence of drugs (DUID) applications. This study demonstrates the implementation of the first comprehensive OF drug testing program in the United States, including approved roadside screening OF devices for law enforcement and validated liquid chromatography–tandem mass spectrometry (LC–MS-MS) confirmation methods. Three roadside OF screening devices were evaluated: the Dräger DrugTest® 5000, Abbott SoToxa®, and Randox Evidence MultiSTAT™. Two qualitative LC–MS-MS confirmation methods were validated per ASB Standard 036. The first method utilized an automated dispersive pipette extraction extraction using Integra and Hamilton STARlet platforms for drugs of abuse. The second method used a liquid–liquid extraction to detect cannabinoids. The prevalence of drugs in blood and OF was monitored over 5 years of casework. Calibration curves were analyzed with each batch to monitor OF concentrations for research purposes. Three roadside OF screening devices were deemed fit for purpose. Devices demonstrated appropriate sensitivity, specificity, positive and negative predictive values, and accuracy above 80% for targeted drugs except for benzodiazepines (DrugTest® 5000) and amphetamine (SoToxa®). The validated LC–MS-MS OF confirmation methods met the National Safety Council-recommended cutoffs for 18/21 (86%) of the targets. Over 5 years of casework, THC and cocaine were detected at a positivity rate of 90% and 97% in OF versus 75% and 44% in blood, respectively. OF:blood ratios exceeded unity for parent drugs. Median concentrations of THC in OF and blood were 31 and 3.5 ng/mL, respectively. OF is a viable alternative or supplemental specimen for DUID investigations. Collecting OF close to the driving event increases the opportunity to identify pharmacologically active substances, and when combined with blood analysis results, an elevated OF:blood ratio provides valuable information for DUID investigation purposes.
Acibenzolar-S-methyl induces resistance against ambrosia beetle attacks in dogwoods exposed to simulated flood stress
Authors: Parajuli Madhav , Oksel Cansu , Neupane Krishna , Ranger Christopher M , Oliver Jason B , Addesso Karla M , Baysal-Gurel Fulya 
Published: August 2023

Abstract
Xylosandrus spp. ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) are important wood-boring pests of nursery trees weakened by abiotic and biotic stressors. Acibenzolar-S-methyl (ASM), a plant defense elicitor, was tested for inhibiting Xylosandrus spp. tunneling (i.e., attacks) into flood-stressed flowering dogwoods (Cornus florida L. (Cornales: Cornaceae)). Container-grown dogwoods were treated with ASM substrate drench + flooding, ASM foliar spray + flooding, ASM drench + no flooding, ASM foliar + no flooding, no ASM + flooding, or no ASM + no flooding at 3 days before flood stress in a completely randomized design under field conditions. Trees were flooded for 14 days and then drained and watered as needed. Attacks were counted every 2 days for 28 days. Plant tissue samples were collected at 7 and 14 days after flooding to determine ethanol content using solid-phase microextraction–gas chromatography–mass spectrometry. Trees were dissected to determine gallery formation and depth, fungal colonization, and the presence of eggs, larvae, and adults. The highest number of Xylosandrus beetle species attacks were recorded from plants exposed to no ASM + flooding, but attacks were reduced in ASM treated trees (drench or foliar) + flooding. Trees treated with drenches had fewer attacks than foliar sprays. Plants assigned to no flood had the fewest beetle attacks. Moreover, ASM reduced Xylosandrus spp. gallery formation and depth, fungal colonization, and presence of eggs, larvae, and adults. All flooded trees produced ethanol. In conclusion, ASM induced a plant defense response to Xylosandrus spp. tunneling in dogwoods under flood stress conditions.