bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience with the safe admission of breast and thyroid cancer patients in non-endemic areas during an epidemic outbreak
Authors: Tang Peng , Ai Xiang , Wang Minghao , Hu Ying , Pan Qinwen , Jiang Jun 
Published: September 2023

BackgroundThe outbreaks of infectious diseases, such as coronavirus disease 2019 (COVID-19), have seriously affected the normal work and life of the public, as well as the normal diagnosis and treatment of other diseases due to their strong infectivity, high population susceptibility, and diverse clinical manifestations. Breast and thyroid specialists in non-hotspot epidemic areas of COVID-19 must consider factors, including epidemic prevention and control, breast and thyroid cancers and diseases diagnosis and treatment, and access to medical resources to make a reasonable treatment choice and optimize the treatment process.MethodsA cohort study was designed under our center’s epidemic prevention and control strategy. The study was conducted between February 3 and April 19, 2020, to explore the safety of clinical diagnosis and treatment of breast and thyroid cancer patients during the epidemic. All the outpatients, inpatients, day-time chemotherapy patients, targeted therapy patients, and relevant medical staff in the observation period in the Department of Breast and Thyroid Surgery in Southwest Hospital in Chongqing municipality, China, were included to investigate the detection and infection rate of COVID-19 and suspected patients.ResultsDuring the observation period, 27,117 patients were admitted to the outpatient unit. We performed 394 inpatient surgeries and 411 day-time surgeries. In our center, 1,046 and 663 patients received day-time chemotherapy and targeted therapy, respectively. All the patients were diagnosed and treated promptly and safely. Three suspected COVID-19 patients were identified in the outpatient unit. Healthcare staff achieved a “zero” infection of COVID-19.ConclusionThe spread and cross-infection of COVID-19 can be avoided in non-hotspot epidemic areas based on scientific prevention and control, and cancer patients can be diagnosed and treated on time. The prevention and control measure implemented in the COVID-19 epidemic for diagnosing and treating cancer patients was effective and can be referenced for other infectious disease outbreaks.
Identification of novel lactate metabolism-related lncRNAs with prognostic value for bladder cancer
Authors: Wang Xiushen , Pan Jing , Guan Qiutong , Ren Ninghui , Wang Ping , Wei Minjie , Li Zhenhua 
Published: September 2023

Background: Bladder cancer (BCA) has high recurrence and metastasis rates, and current treatment options show limited efficacy and significant adverse effects. It is crucial to find diagnostic markers and therapeutic targets with clinical value. This study aimed to identify lactate metabolism-related lncRNAs (LM_lncRNAs) to establish a model for evaluating bladder cancer prognosis.Method: A risk model consisting of lactate metabolism-related lncRNAs was developed to forecast bladder cancer patient prognosis using The Cancer Genome Atlas (TCGA) database. Kaplan‒Meier survival analysis, receiver operating characteristic curve (ROC) analysis and decision curve analysis (DCA) were used to evaluate the reliability of risk grouping for predictive analysis of bladder cancer patients. The results were also validated in the validation set. Chemotherapeutic agents sensitive to lactate metabolism were assessed using the Genomics of Drug Sensitivity in Cancer (GDSC) database.Results: As an independent prognostic factor for patients, lactate metabolism-related lncRNAs can be used as a nomogram chart that predicts overall survival time (OS). There were significant differences in survival rates between the high-risk and low-risk groups based on the Kaplan‒Meier survival curve. decision curve analysis and receiver operating characteristic curve analysis confirmed its good predictive capacity. As a result, 22 chemotherapeutic agents were predicted to positively affect the high-risk group.Conclusion: An lactate metabolism-related lncRNA prediction model was proposed to predict the prognosis for patients with bladder cancer and chemotherapeutic drug sensitivity in high-risk groups, which provided a new idea for the prognostic evaluation of the clinical treatment of bladder cancer.
Cultivation of Melilotus officinalis as a source of bioactive compounds in association with soil recovery practices
Authors: Nogues Isabel , Passatore Laura , Bustamante María Ángeles , Pallozzi Emanuele , Luz João , Traquete Francisco , Ferreira António E. N. , Sousa Silva Marta , Cordeiro Carlos 
Published: September 2023

IntroductionMelilotus officinalisis a Leguminosae with relevant applications in medicine and soil recovery. This study reports the application ofMelilotus officinalisplants in soil recovery and as a source of bioactive compounds.MethodsPlants were cultivated in semiarid soil under four different fertilizer treatments, urban waste compost at 10 t/ha and 20 t/ha, inorganic fertilizer and a control (no fertilizer). Agronomic properties of soil (pH, EC, soil respiration, C content, macro- and microelements) were analyzed before and after treatment. Also, germination, biomass, element contents, and physiological response were evaluated. Metabolite composition of plants was analyzed through Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS).Results and discussionResults showed a significant enhancement of the soil microbial activity in planted soils amended with compost, though there were no other clear effects on the soil physicochemical and chemical characteristics during the short experimental period. An improvement inM. officinalisgermination and growth was observed in soils with compost amendment. Metabolite composition of plants was analyzed through Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Principal Component and Agglomerative Hierarchical Clustering models suggest that there is a clear separation of the metabolome of four groups of plants grown under different soil treatments. The five most important discriminative metabolites (annotated) were oleamide, palmitic acid, stearic acid, 3-hydroxy-cis-5-octenoylcarnitine, and 6-hydroxynon-7- enoylcarnitine. This study provides information on how the metabolome ofMelilotusmight be altered by fertilizer application in poor soil regions. These metabolome changes might have repercussions for the application of this plant in medicine and pharmacology. The results support the profitability ofMelilotus officinaliscultivation for bioactive compounds production in association with soil recovery practices.
What are the core features of professional learning community in Chinese preschool teachers’ perspectives: based on grounded theory analysis
Authors: Yang Jia , Zhang Yifan , Zhou Yibin , Ji Yulin 
Published: September 2023

IntroductionProfessional learning community (PLC) has been concerned as an effective way to promote teacher professional development in China. However, PLC must be optimized due to Chinese culture and education system. This study aimed to explore the features of PLC in preschool teachers’ perspectives and provided theoretical basis for PLC localization practice.MethodsTwenty-eight preschool teachers were engaged in a PLC, their interview data and personal reflection diaries were collected and analyzed based on grounded theory analysis.Results and discussionFive core features of PLC in teachers’ perspectives were extracted in this study, including a common vision, a read-practice-share flow, continuous reflection, distributed leadership, peer and organizational support. PLC’s common vision is to promote teachers’ professional development and children’s development. Teachers learn and reflect in the process of “reading-practice-sharing,” peer support and leadership empowerment play an important role in a sustainable PLC.
The relationship between fundamental motor skills and physical fitness in preschoolers: a short-term longitudinal study
Authors: Chen Jiebo , Song Wenjing , Zhao Xing , Lou Hu , Luo Dongmei 
Published: September 2023

PurposePhysical fitness and fundamental motor skills are two important aspects for the healthy development of preschoolers. Despite the growing interest in clarifying their relationship, the scarcity of longitudinal studies prevents us from understanding causality.MethodThis study employed a cross-lagged model with two time points to investigate the bidirectional relationship between these two aspects. A total of 174 preschoolers (54.0% girls) from 3 to 6 years old (M = 3.96 ± 0.47) were surveyed, they were recruited by convenience from two kindergartens in Beijing, China, and their physical fitness (via CNPFDSM-EC) and fundamental motor skills (via TGMD-3) were tracked over a period of 6 months.ResultsThe findings revealed a bidirectional predictive effect. The predictive strength of flexibility was found to be lower than other physical fitness aspects, while locomotor skills demonstrated a higher predictive strength than object control skills.ConclusionThis study indicates that physical fitness and fundamental motor skills mutually enhance each other in young children, and both should be emphasized in preschool sports education.
When practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants
Authors: Chrobak Adrian Andrzej , Siuda-Krzywicka Katarzyna , Soltys Zbigniew , Bielak Sylwia , Nowaczek Dominik , Żyrkowska Aleksandra , Fafrowicz Magdalena , Marek Tadeusz , Pęcherzewska Ewa , Kużdżał Jan , Starowicz-Filip Anna , Gorostowicz Aleksandra , Dudek Dominika , Siwek Marcin 
Published: September 2023

IntroductionOur previous studies identified a paradoxical implicit motor learning curve in schizophrenia (SZ) and bipolar disorder (BD) patients. This study aimed to verify whether those previously observed deficits may be captured by a new version of the ambidextrous serial reaction time task (SRTT), prepared for use in the MRI.MethodsThis study involved 186 participants. A total of 97 participants (33 BD, 33 SZ, and 31 healthy controls, HCs) completed the original, unlimited time response variant of SRTT. A total of 90 individuals (30 BD, 30 SZ, and 30 HCs) underwent a newer, limited response time version of this procedure.ResultsThere was no significant difference in terms of implicit motor learning indices between both limited and unlimited response time SRTT. Compared to HCs, SZ, and BD patients presented decreased indices of implicit motor learning. Both clinical groups showed a paradoxical learning pattern that differed significantly from the HCs. Moreover, in the SZ group, the pattern depended on the hand performing SRTT.DiscussionThe limited response time SRTT variant allowed us to replicate the findings of disrupted implicit motor learning in SZ and BD. The use of this paradigm in further neuroimaging studies may help to determine the neuronal underpinnings of this cognitive dysfunction in the abovementioned clinical groups.
Satisfaction with sex life and its impact on the quality of life in people living with HIV in Poland treated in the city of Bialystok: a cross-sectional study
Authors: Milewska-Buzun Marta , Cybulski Mateusz , Baranowska Anna , Krajewska-Kułak Elżbieta , Kózka Maria , Paradowska-Stankiewicz Iwona 
Published: September 2023

IntroductionSex life is an important element contributing to the overall quality of life. It is also a particularly sensitive dimension of quality of life for HIV-positive patients.ObjectiveThe aim of the study was to assess the sexual life of people living with HIV in Poland treated in the Observation and Infection Clinic with the Subunit for HIV/AIDS Patients of the University Clinical Hospital in Bialystok, and its impact on the quality of life, life satisfaction, HIV status acceptance, general health status and depressive symptoms among the respondents.MethodsA total of 147 participants, including 104 men (70.7%) and 43 women (29.3%), took part in the research. The study was conducted between May 2019 and January 2020. The study used a diagnostic survey method with a modified questionnaire “Psychosocial situation of people living with HIV/AIDS” by Dr. Magdalena Ankiersztejn-Bartczak and the following standardised psychometric tools: the World Health Organization Quality of Life (WHOQOL-BREF), Short Form Health Survey (SF-36), Acceptance of Illness Scale (AIS), Satisfaction with Life Scale (SWLS), General Health Questionnaire (GHQ-28) and Beck Depression Inventory (BDI).ResultsOne-third of patients rated their sex life as poor or very poor. Almost half of respondents always informed sexual partners of their HIV status (49.7%). The sex life of respondents was highly correlated with almost all psychometric measures used in the study. Those indicating sexual contact as a possible source of HIV infection had a lower quality of life in the domain of general health compared to other respondents, but the difference was relatively small (about 5.5 points).DiscussionIn conclusion, the overall satisfaction with the sex life of people living with HIV was moderate with a tendency to poor. The quality of life of people living with HIV was determined by their sex life. Better quality of life was presented by those with good self-reported sex life.
Self-care with non-prescription medicines to improve health care access and quality of life in low- and middle-income countries: systematic review and methodological approach
Authors: May Uwe , Bauer Cosima , Schneider-Ziebe Anissa , Giulini-Limbach Chiara 
Published: September 2023

ObjectivesThis study aims to develop a structured framework to capture beneficial effects and determine the value of self-care for individuals and society in low- and middle-income countries (LMICs). A special focus is placed on self-medication with non-prescription medicines.MethodsPubMed, Google Scholar and websites of associations or organizations were systematically searched for economic studies on self-care and self-medication published between 2000 and 2021. The insights gained from the literature review were incorporated into the development of a decision tree model.ResultsThe literature review revealed a lack of research and available data on the role and value of self-care in LMICs. To help close the research gap a methodological framework was developed that defines different settings of self-care, their effects and relevant outcomes and allows a quantification with regard to self-medication in LMICs.ConclusionSelf-care offers individuals a convenient and reliable way to take care of their own health, especially in LMICs where access to health services can be challenging. In particular it is crucial to improve individuals access to clinically effective, safe and reliable non-prescription medicines.
Exploring factors related to heart attack complicated with hypertension using a Bayesian network model: a study based on the China Health and Retirement Longitudinal Study
Authors: Zhang Haifen , Zhang Xiaotong , Yao Xiaodong , Wang Qiang 
Published: September 2023

ObjectivesWhile Bayesian networks (BNs) represents a good approach to discussing factors related to many diseases, little attention has been poured into heart attack combined with hypertension (HAH) using BNs. This study aimed to explore the complex network relationships between HAH and its related factors, and to achieve the Bayesian reasoning for HAH, thereby, offering a scientific reference for the prevention and treatment of HAH.MethodsThe data was downloaded from the Online Open Database of CHARLS 2018, a population-based longitudinal survey. In this study, we included 16 variables from data on demographic background, health status and functioning, and lifestyle. First, Elastic Net was first used to make a feature selection for highly-related variables for HAH, which were then included into BN model construction. The structural learning of BNs was achieved using Tabu algorithm and the parameter learning was conducted using maximum likelihood estimation.ResultsAmong 19,752 individuals (9,313 men and 10,439 women) aged 64.73 ± 10.32 years, Among 19,752 individuals (9,313 men and 10,439 women), there are 8,370 ones without HAH (42.4%) and 11,382 ones with HAH (57.6%). What’s more, after feature selection using Elastic Net, Physical activity, Residence, Internet access, Asset, Marital status, Sleep duration, Social activity, Educational levels, Alcohol consumption, Nap, BADL, IADL, Self report on health, and age were included into BN model establishment. BNs were constructed with 15 nodes and 25 directed edges. The results showed that age, sleep duration, physical activity and self-report on health are directly associated with HAH. Besides, educational levels and IADL could indirectly connect to HAH through physical activity; IADL and BADL could indirectly connect to HAH through Self report on health.ConclusionBNs could graphically reveal the complex network relationship between HAH and its related factors. Besides, BNs allows for risk reasoning for HAH through Bayesian reasoning, which is more consistent with clinical practice and thus holds some application prospects.
An interdisciplinary intervention program to prevent early childhood caries in the Dominican Republic
Authors: Abreu-Placeres Ninoska , Ekstrand Kim Rud , Garrido Luis Eduardo , Bakhshandeh Azam , Martignon Stefania 
Published: September 2023

ObjectiveThe principal aim of this randomized clinical trial (RCT) was to test the effectiveness in the prevention of Early Childhood Caries (ECC) through an educational intervention program with the use of a printed guide for pediatricians and parents both designed by pediatric dentists.Materials and methodsAfter ethical approval, the first step was to design the educational guides, which were based on the information obtained from a focus group with pediatricians (n = 3), phone interviews with mothers to toddlers' (n = 7), and the best evidence available about children's oral health. For the RCT, 309 parents with their 10–12 months old children were randomly allocated to either the intervention or the control group. Parents in the intervention group received oral health education from the pediatricians supported by the printed guides. Parents in both groups received an oral health kit with a toothbrush and toothpaste at the first visit as well as at each 6-month follow-up visit. After 18 months the children were evaluated using ICDAS criteria.ResultsAt baseline, data were available from 309 children (49.8% girls). The mean age of the children was of 10.8 months (SD = 0.8) and 69.3% had not had their teeth brushed with toothpaste. After 18 months, a total of 28 (22%) children in the intervention group and 44 (24%) in the control group were clinically examined. Regarding the number of tooth surfaces with caries lesions, the children in the intervention group had a mean of 6.50 (SD = 6.58) surfaces, while the children in the control group had a mean of 5.43 (SD = 4.74) surfaces with caries lesions. This difference was not significant (p = 0.460).ConclusionThe RCT showed no effectiveness in caries-progression control. Despite this result, this study managed to identify barriers that do not allow pediatricians from offering parents adequate oral health recommendations. With this learning, it is possible to work on collaborative programs with pediatricians that over time likely will increase dental health by controlling for ECC.
Impact of suboptimal donor to suboptimal recipient kidney transplant on delayed graft function and outcome
Authors: Bocchi Federica , Beldi Guido , Kuhn Christian , Storni Federico , Müller Natalie , Sidler Daniel 
Published: September 2023

IntroductionThe demographics of donor and recipient candidates for kidney transplantation (KT) have substantially changed. Recipients tend to be older and polymorbid and KT to suboptimal recipients is associated with delayed graft function (DGF), prolonged hospitalization, inferior long-term allograft function, and poorer patient survival. In parallel, donors are also older, suffer from several comorbidities, and donations coming from circulatory death (DCD) predominate, which in turn leads to early and late complications. However, it is unclear how donor and recipient risk factors interact.MethodsIn this retrospective cohort study, we assess the impact of a KT from suboptimal donors to suboptimal recipients. We focused on: 1) DGF; 2) hospital stay and number of dialysis days after KT and 3) allograft function at 12 months.Results and discussionAmong the 369 KT included, the overall DGF rate was 25% (n = 92) and median time from reperfusion to DGF resolution was 7.8 days (IQR: 3.0–13.8 days). Overall, patients received four dialysis sessions (IQR: 2–8). The combination of pre-KT anuria (&lt;200 ml/24 h, 32%) and DCD procurement (14%) was significantly associated with DGF, length of hospital stay, and severe perioperative complications, predominantly in recipients 50 years and older.
Two-Component Rare-Earth Fluoride Materials with Negative Thermal Expansion Based on a Phase Transition-Type Mechanism in 50 RF3-R’F3 (R = La-Lu) Systems
Authors: Sobolev Boris P. , Sulyanova Elena A. 
Published: September 2023

The formation of materials with negative thermal expansion (NTE) based on a phase transition-type mechanism (NTE-II) in 50 T–x (temperature–composition) RF3-R’F3 (R = La-Lu) systems out of 105 possible is predicted. The components of these systems are “mother” RF3 compounds (R = Pm, Sm, Eu, and Gd) with polymorphic transformations (PolTrs), which occur during heating between the main structural types of RF3: β-(β-YF3) → t-(mineral tysonite LaF3). The PolTr is characterized by a density anomaly: the formula volume (Vform) of the low-temperature modification (Vβ-) is higher than that of the high-temperature modification (Vt-) by a giant value (up to 4.7%). In RF3-R’F3 systems, isomorphic substitutions chemically modify RF3 by forming R1−xR’xF3 solid solutions (ss) based on both modifications. A two-phase composite (β-ss + t-ss) is a two-component NTE-II material with adjustable parameters. The prospects of using the material are estimated using the parameter of the average volume change (ΔV/Vav). The Vav at a fixed gross composition of a system is determined by the β-ss and t-ss decay (synthesis) curves and the temperature T. The regulation of ΔV/Vav is achieved by changing T within a “window ΔT”. The available ΔT values are determined using phase diagrams. A chemical classification (ChCl) translates the search for NTE-II materials from 15 RF3 into an array of 105 RF3-R’F3 systems. Phase diagrams are divided into 10 types of systems (TypeSs), in four of which NTE-II materials are formed. The tables of the systems that comprise these TypeSs are presented. The position of Ttrans of the PolTr on the T scale for a short quasi-system (QS) “from PmF3 to TbF3” determines the interval of the ΔTtrans offset achievable in the RF3-R’F3 systems: from −148 to 1186 ± 10 °C. NTE-II fluoride materials exceed known NTE-II materials by almost three times in this parameter. Equilibrium in RF3-R’F3 systems is established quickly. The number of qualitatively different two-component fluoride materials with the giant NTE-II can be increased by more than ten times compared to RF3 with NTE-II.