bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards a Holistic and Functional Model-Based Design Method for Mechatronic Cyber-Physical Systems
Authors: Hoepfner Gregor , Nachmann Imke , Zerwas Thilo , Berroth Joerg K. , Kohl Jens , Guist Christian , Rumpe Bernhard , Jacobs Georg 
Published: January 2023

AbstractEngineering cyber-physical systems (CPS) is complex and time-consuming due to the heterogeneity of the involved engineering domains and the high number of physical and logical interactions of their subsystems. Model-based systems engineering (MBSE) approaches tackle the complexity of developing CPS by formally and explicitly modeling subsystems and their interactions. Newer approaches also integrate domain-specific models and modeling languages to cover different aspects of CPS. However, MBSE approaches are currently not fully applicable for CPS development since they do not integrate formal models for physical and mechanical behavior to an extent that allows to seamlessly link mechanical models to the digital models and reuse them. In this paper, we discuss the challenges arising from the missing integration of physics into MBSE and introduce a model-based methodology capable of integrating physical functions and effects into an MBSE approach on a level where detailed physical effects are considered. Our approach offers a fully virtual, model-based development methodology covering the whole development process for the development of CPS. Evaluating this methodology on a real automotive use case demonstrates benefits regarding virtual development and functional testing of CPS. It shows potentials regarding automated development and continuous integration of the whole CPS including all domains. As an outlook of this paper, we discuss potential further research topics extending our development workflow.
Supplemental Material: Newly recognized blueschist-facies metamorphism (glaucophane-omphacite-garnet), Belvidere Mountain Complex, northern Appalachians
Authors: Honsberger I.W. 
Published: January 2023

<p>Text File 1: Mineral nomenclature and analytical methods. Text File 2: Procedures for pseudosection calculations. Table S1: All electron microprobe analyses, Belvidere Mountain Complex amphibolites. </p>
Semi-supervised graph neural networks for pileup noise removal
Authors: Li Tianchun , Liu Shikun , Feng Yongbin , Paspalaki Garyfallia , Tran Nhan V. , Liu Miaoyuan , Li Pan 
Published: January 2023

AbstractThe high instantaneous luminosity of the CERN Large Hadron Collider leads to multiple proton–proton interactions in the same or nearby bunch crossings (pileup). Advanced pileup mitigation algorithms are designed to remove this noise from pileup particles and improve the performance of crucial physics observables. This study implements a semi-supervised graph neural network for particle-level pileup noise removal, by identifying individual particles produced from pileup. The graph neural network is firstly trained on charged particles with known labels, which can be obtained from detector measurements on data or simulation, and then inferred on neutral particles for which such labels are missing. This semi-supervised approach does not depend on the neutral particle pileup label information from simulation, and thus allows us to perform training directly on experimental data. The performance of this approach is found to be consistently better than widely-used domain algorithms and comparable to the fully-supervised training using simulation truth information. The study serves as the first attempt at applying semi-supervised learning techniques to pileup mitigation, and opens up a new direction of fully data-driven machine learning pileup mitigation studies.
Strong enhancement of electromagnetic shower development induced by high-energy photons in a thick oriented tungsten crystal
Authors: Soldani M. , Bandiera L. , Moulson M. , Ballerini G. , Baryshevsky V. G. , Bomben L. , Brizzolari C. , Charitonidis N. , D’Alessandro G. L. , De Salvador D. , van Dijk M. , Georgiev G. , Gianoli A. , Guidi V. , Haurylavets V. , Lobko A. S. , Maiolino T. , Mascagna V. , Mazzolari A. , Petrucci F. C. , Prest M. , Romagnoni M. , Rubin P. , Soldi D. , Sytov A. , Tikhomirov V. V. , Vallazza E. 
Published: January 2023

AbstractWe have observed a significant enhancement in the energy deposition by 25–$$100~\textrm{GeV}$$

100

GeV

photons in a $$1~\textrm{cm}$$

1

cm

thick tungsten crystal oriented along its $$\langle 111 \rangle $$

⟨
111
⟩

lattice axes. At $$100~\textrm{GeV}$$

100

GeV

, this enhancement, with respect to the value observed without axial alignment, is more than twofold. This effect, together with the measured huge increase in secondary particle generation is ascribed to the acceleration of the electromagnetic shower development by the strong axial electric field. The experimental results have been critically compared with a newly developed Monte Carlo adapted for use with crystals of multi-$$X_0$$

X
0

thickness. The results presented in this paper may prove to be of significant interest for the development of high-performance photon absorbers and highly compact electromagnetic calorimeters and beam dumps for use at the energy and intensity frontiers.
Cosmology of modified holographic f(G) gravity and study of baryogenesis
Authors: Chakraborty Gargee , Beesham Aroonkumar , Chattopadhyay Surajit 
Published: January 2023

Motivated by the work of Nojiri and Odintsov [Phys. Lett. B 631 (2005) 1–6, arXiv:hep-th/0508049 [hep-th]], this work reports on the cosmology and baryogenesis of modified [Formula: see text] gravity by assuming the background evolution as generalized holographic dark energy (GHDE). For vacuum energy density, modified [Formula: see text] gravity is reconstructed and found to be of positive behavior. The equation of state (EoS) parameter under the purview of vacuum energy density comes out to be quintom. The reconstructed modified [Formula: see text] gravity in GHDE shows positive behavior, and its corresponding EoS parameter is phantom. There is a chance of a big rip singularity and the slow roll parameters are analyzed. Quasi exponential expansion and warm inflation are observed. Finally, baryogenesis is studied. The study suggests that either there may be symmetry between the number density of baryons and antibaryons in the far future, or the generalized second law of thermodynamics is satisfied by the model.
Report on the 2nd Joint Conference of the Information Retrieval Communities in Europe (CIRCLE 2022)
Authors: Tamine Lynda , Amigó Enrique , Mothe Josiane 
Published: January 2023

The Joint Conference of the Information Retrieval Communities in Europe (CIRCLE 2020) is the second joint conference of the French, Italian, and Spanish information retrieval communities. The three days of conference gathered interesting studies and research work on a wide range of topics on information retrieval, such as topic and document modeling, web search, information retrieval in e-government, social media, recommender systems, information retrieval evaluation, indexing and annotation, user profiling and interaction, frameworks and systems, and semantic extraction.
It was hosted by Université de Toulouse, France in a holiday resort at Samatan.

Date:
4--7 July, 2022.

Website:
https://www.irit.fr/CIRCLE/.
CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer
Authors: Faraoni Erika Y. , Singh Kanchan , Chandra Vidhi , Le Roux Olivereen , Dai Yulin , Sahin Ismet , O'Brien Baylee J. , Strickland Lincoln N. , Li Le , Vucic Emily , Warner Amanda N. , Pruski Melissa , Clark Trent , Van Buren George , Thosani Nirav C. , Bynon John S. , Wray Curtis J. , Bar-Sagi Dafna , Poulsen Kyle L. , Vornik Lana A. , Savage Michelle I. , Sei Shizuko , Mohammed Altaf , Zhao Zhongming , Brown Powel H. , Mills Tingting , Eltzschig Holger K. , McAllister Florencia , Bailey-Lundberg Jennifer M. 
Published: January 2023

AbstractThe microenvironment that surrounds pancreatic ductal adenocarcinoma (PDAC) is profoundly desmoplastic and immunosuppressive. Understanding triggers of immunosuppression during the process of pancreatic tumorigenesis would aid in establishing targets for effective prevention and therapy. Here, we interrogated differential molecular mechanisms dependent on cell of origin and subtype that promote immunosuppression during PDAC initiation and in established tumors. Transcriptomic analysis of cell-of-origin–dependent epithelial gene signatures revealed that Nt5e/CD73, a cell-surface enzyme required for extracellular adenosine generation, is one of the top 10% of genes overexpressed in murine tumors arising from the ductal pancreatic epithelium as opposed to those rising from acinar cells. These findings were confirmed by IHC and high-performance liquid chromatography. Analysis in human PDAC subtypes indicated that high Nt5e in murine ductal PDAC models overlaps with high NT5E in human PDAC squamous and basal subtypes, considered to have the highest immunosuppression and worst prognosis. Multiplex immunofluorescent analysis showed that activated CD8+ T cells in the PDAC tumor microenvironment express high levels of CD73, indicating an opportunity for immunotherapeutic targeting. Delivery of CD73 small-molecule inhibitors through various delivery routes reduced tumor development and growth in genetically engineered and syngeneic mouse models. In addition, the adenosine receptor Adora2b was a determinant of adenosine-mediated immunosuppression in PDAC. These findings highlight a molecular trigger of the immunosuppressive PDAC microenvironment elevated in the ductal cell of origin, linking biology with subtype classification, critical components for PDAC immunoprevention and personalized approaches for immunotherapeutic intervention.Significance:Ductal-derived pancreatic tumors have elevated epithelial and CD8+GZM+ T-cell CD73 expression that confers sensitivity to small-molecule inhibition of CD73 or Adora2b to promote CD8+ T-cell–mediated tumor regression.See related commentary by DelGiorno, p. 977
Sensor and internet of things based integrated inundation mitigation for smart city
Authors: Al Kindhi Berlian , Lasminto Umboro , Triana Masca Indra , Damarnegara Satria , Anavatti Sreenatha G. 
Published: January 2023

<span lang="EN-US">Flooding is a natural phenomenon that often occurs in tropical countries. Drainage design is one of the efforts to prevent floods, however, when the rainfall is high, there are still several inundation points that occur. This requires comprehensive handling to reduce the impact of these inundations, to get an adaptive solution, the use of internet of things based (IoT) tools is one of the alternatives proposed. This study proposes an IoT-based flood inundation monitoring system, which includes a water level reader, a web-based inundation monitoring system, a flood inundation area and depth reporting system as evaluation materials for the government city. The sensor module that we propose is a series of sensors in a hollow cylinder design to reduce water ripples. The server application is displayed in the form of an interactive area mapping which is divided into 4 layers for 4 different analyzes so that central officers can quickly coordinate with field officers to carry out mitigation actions in the affected area. The module requires a low cost and easy installation process compared to a liquid sensor, besides that the display in the form of a web makes it easier for officers to access monitoring applications anywhere compared to geographic information system based (GIS) applications. This research has been carried out and tested in one of the major cities in Indonesia.</span>
Multi-label learning by extended multi-tier stacked ensemble method with label correlated feature subset augmentation
Authors: Hemavati Hemavati , Devi Visweswariah Susheela , Aparna Ramalingappa 
Published: January 2023

<p>Classification is one of the basic and most important operations that can be used in data science and machine learning applications. Multi-label classification is an extension of the multi-class problem where a set of class labels are associated with a particular instance at a time. In a multiclass problem, a single class label is associated with an instance at a time. However, there are many different stacked ensemble methods that have been proposed and because of the complexity associated with the multi-label problems, there is still a lot of scope for improving the prediction accuracy. In this paper, we are proposing the novel extended multi-tier stacked ensemble (EMSTE) method with label correlation<br />by feature subset selection technique and then augmenting those feature subsets while constructing the intermediate dataset for improving the prediction accuracy in the generalization phase of the stacking. The performance effect of the proposed method has been compared with existing methods and showed that our proposed method outperforms the other methods.</p>
Growth Differentiation Factor‐15 Predicts Mortality and Heart Failure Exacerbation But Not Ventricular Arrhythmias in Patients With Cardiomyopathy
Authors: Binder M. Scott , Yanek Lisa R. , Yang Wanjun , Butcher Barbara , Norgard Sanaz , Marine Joseph E. , Kolandaivelu Aravindan , Chrispin Jonathan , Fedarko Neal S. , Calkins Hugh , O'Rourke Brian , Wu Katherine C. , Tomaselli Gordon F. , Barth Andreas S. 
Published: January 2023

Background
Heart failure (HF) has been increasing in prevalence, and a need exists for biomarkers with improved predictive and prognostic ability. GDF‐15 (growth differentiation factor‐15) is a novel biomarker associated with HF mortality, but no serial studies of GDF‐15 have been conducted. This study aimed to investigate the association between GDF‐15 levels over time and the occurrence of ventricular arrhythmias, HF hospitalizations, and all‐cause mortality.

Methods and Results

We used a retrospective case–control design to analyze 148 patients with ischemic and nonischemic cardiomyopathies and primary prevention implantable cardioverter‐defibrillator (ICD) from the PROSe‐ICD (Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention) cohort. Patients had blood drawn every 6 months and after each appropriate ICD therapy and were followed for a median follow‐up of 4.6 years, between 2005 to 2019. We compared serum GDF‐15 levels within ±90 days of an event among those with a ventricular tachycardia/fibrillation event requiring ICD therapies and those hospitalized for decompensated HF. A comparator/control group comprised patients with GDF‐15 levels available during 2‐year follow‐up periods without events. Median follow‐up was 4.6 years in the 148 patients studied (mean age 58±12, 27% women). The HF cohort had greater median GDF‐15 values within 90 days (1797 pg/mL) and 30 days (2039 pg/mL) compared with the control group (1062 pg/mL, both
P
<0.0001). No difference was found between the ventricular tachycardia/fibrillation subgroup within 90 days (1173 pg/mL,
P
=0.60) or 30 days (1173 pg/mL,
P
=0.78) and the control group. GDF‐15 was also significantly predictive of mortality (hazard ratio, 3.17 [95% CI, 2.33–4.30]).

Conclusions
GDF‐15 levels are associated with HF hospitalization and mortality but not ventricular arrhythmic events.
Periodontal Disease Associated With Interstitial Myocardial Fibrosis: The Multiethnic Study of Atherosclerosis
Authors: Doughan Maria , Chehab Omar , de Vasconcellos Henrique Doria , Zeitoun Ralph , Varadarajan Vinithra , Doughan Bassel , Wu Colin O. , Blaha Michael J , Bluemke David A. , Lima Joao A. C. 
Published: January 2023

Background
Periodontitis is a chronic inflammatory disease common among adults. It has been suggested that periodontal disease (PD) may be a contributing risk factor for cardiovascular disease; however, pathways underlying such a relationship require further investigation.

Methods and Results

A total of 665 men (mean age 68±9 years) and 611 women (mean age 67±9 years) enrolled in the MESA (Multiethnic Study of Atherosclerosis) underwent PD assessment using a 2‐item questionnaire at baseline (2000–2002) and had cardiovascular magnetic resonance 10 years later. PD was defined when participants reported either a history of periodontitis or gum disease or lost teeth caused by periodontitis or gum disease. Multivariable linear regression models were constructed to assess the associations of baseline self‐reported PD with cardiovascular magnetic resonance–obtained measures of interstitial myocardial fibrosis (IMF), including extracellular volume and native T1 time. Men with a self‐reported history of PD had greater extracellular volume percent (ß=0.6%±0.2,
P
=0.01). This association was independent of age, left ventricular mass, traditional cardiovascular risk factors, and history of myocardial infarction. In a subsequent model, substituting myocardial infarction for coronary artery calcium score, the association of PD with IMF remained significant (ß=0.6%±0.3,
P
=0.03). In women, a self‐reported history of PD was not linked to higher IMF. Importantly, a self‐reported history of PD was not found to be associated with myocardial scar independent of sex (odds ratio, 1.01 [95% CI, 0.62–1.65];
P
=0.9).

Conclusions
In a community‐based setting, men but not women with a self‐reported PD history at baseline were found to be associated with increased measures of IMF. These findings support a plausible link between PD, a proinflammatory condition, and subclinical IMF.
The Cult of the Persuasive: Why U.S. Security Assistance Fails
Authors: Metz Rachel Tecott 
Published: January 2023

Abstract
Security assistance is a pillar of U.S. foreign policy and a ubiquitous feature of international relations. The record, however, is mixed at best. Security assistance is hard because recipient leaders are often motivated to implement policies that keep their militaries weak. The central challenge of security assistance, then, is influence. How does the United States aim to influence recipient leaders to improve their militaries, and what drives its approach? Influence in security assistance can be understood as an escalation ladder with four rungs: teaching, persuasion, conditionality, and direct command. Washington increasingly delegates security assistance to the Department of Defense, and the latter to the U.S. Army. U.S. Army advisers tend to rely exclusively on teaching and persuasion, even when recipient leaders routinely ignore their advice. The U.S. Army's preference for persuasion and aversion to conditionality in security assistance can be traced to its bureaucratic interests and to the ideology that it has developed—the cult of the persuasive—to advance those interests. A case study examines the bureaucratic drivers of the U.S. Army's persistent reliance on persuasion to influence Iraqi leaders to reform and strengthen the Iraqi Army. Qualitative analysis leverages over one hundred original interviews, as well as oral histories and recently declassified U.S. Central Command documents. The findings illustrate how the interests and ideologies of the military services tasked with implementing U.S. foreign policy can instead undermine it.
Push and Pull on the Periphery: Inadvertent Expansion in World Politics
Authors: Anderson Nicholas D. 
Published: January 2023

Abstract
Why do great powers engage in territorial expansion? Much of the existing literature views expansion as a largely intentional activity directed by the leaders of powerful states. Yet nearly 25 percent of important historical instances of great power expansion are initiated by actors on the periphery of the state or empire without authorization from their superiors at the center. Periphery-driven “inadvertent expansion” is most likely to occur when leaders in the capital have limited control over their agents on the periphery. Through their actions, peripheral agents effectively constrain leaders from withdrawing from these newly captured territories because of sunk costs, domestic political pressure, and national honor. When leaders in the capital expect geopolitical consequences from regional or other great powers, such as economic sanctions, militarized crises, or war, they are far less likely to authorize the territorial claims. A mixed-methods research strategy combines new quantitative data on great power territorial expansion with three qualitative case studies of successful (and failed) inadvertent expansion by Russia, Japan, and France. Inadvertent expansion has not completely gone away, particularly among smaller states, where government authority can be weak, control over states’ apparatuses can be loose, and civil-military relations can be challenging.
The Role of Entertainment Media in Promoting Culture: The Case of Japanese Cartoons and Superhero tv Series in 80s-90s Thai Society
Authors: Lopattananont Thanayod 
Published: January 2023

Abstract
This research delved into the specificity of Japanese cartoons and superhero tv series during the 80s-90s based on two questions; how their content familiarized the Thai audience with the culture of Japan and what impact they have delivered. Content analysis, audience analysis, and document research were used as the research methodology. The discovery suggested that Japanese cartoons and superhero tv series were culturally powerful. Their presentation of the local culture was comprehensible, repetitive, and joyous, causing the audience to be connected to the culture of Japan with ease. Each cartoon and superhero tv series also possessed high entertainment quality that drew mass attention from the Thai audience as well as enlarging the consumption scale. This came to light as a result of some creative techniques employed by their creators and, therefore, engendered some significant impacts as explained in the theory of soft power.
Global Soil Moisture–Climate Interactions during the Peak Growing Season
Authors: Feng Yao , Wang Hong , Liu Wenbin , Sun Fubao 
Published: January 2023

Abstract
Soil moisture (SM) during the vegetation growing season largely affects plant transpiration and photosynthesis, and further alters the land energy and water balance through its impact on the energy partition into latent and sensible heat fluxes. To highlight the impact of strong vegetation activity, we investigate global SM–climate interactions over the peak growing season (PGS) during 1982–2015 based on multisource datasets. Results suggest widespread positive SM–precipitation (P), SM–evapotranspiration (ET), and negative SM–temperature (T) interactions with non-negligible negative SM–P, SM–ET, and positive SM–T interactions over PGS. Relative to the influence of individual climate factors on SM, the compounding effect of climate factors strengthens SM–climate interactions. Simultaneously, variations of SM are dominated by precipitation from 50°N toward the south, by evapotranspiration from 50°N toward the north, and by temperature over the Sahara, western and central Asia, and the Tibetan Plateau. Importantly, the higher probability of concurrent SM wetness and climate extremes indicates the instant response of SM wetness to extreme climate. In contrast, the resistance of vegetation partially contributes to a consequent slower response of SM dryness to extreme climate. We highlight the significance of the compounding effects of climate factors in understanding SM–climate interaction in the context of strong vegetation activity, and the response of SM wetness and dryness to climate extremes.