bluuebunny/crossref_metadata_2025_split huggingface dataset:
Democracy, Disagreement, and Authority: A Response to the Symposium on Common Good Constitutionalism
Authors: Vermeule Adrian 
Published: January 2025

Abstract
In this response to a recent symposium on Common Good Constitutionalism in the American Journal of Jurisprudence, I principally take up themes related to democracy, disagreement, pluralism, and authority. I emphasize that the classical legal tradition is teleological, oriented to performance standards rather than design standards. Thus it does not attempt to prescribe an identical set of constitutional and institutional arrangements for all polities everywhere, but asks whether constitutional arrangements are ordered to the common good and (thus) compatible with natural and divine law. Subject to those conditions, political authority is natural, inevitable, inescapable, and good. The possibility of social and political disagreement is just a precondition for all law, not an objection to the classical legal framework. None of this entails judicial supremacism in any form, which the classical legal tradition squarely rejects.
Functional expression mechanisms of food-derived components based on target proteins
Authors: Mitani Takakazu 
Published: January 2025

Abstract
Food-derived polyphenols and some alkaloids have reported bioactivities related to the prevention of systemic metabolic disorders such as obesity, glucose intolerance, and dyslipidemia. For food-derived components to exert their functions in vivo, it is essential to interact with biological factors such as proteins, lipids, and nucleic acids. However, it is still unclear whether bioactive components in foods express functions related to their target factors. In this review, I introduce the target proteins in which food-derived components express functions in cells.
Risk factors for steroid-induced osteonecrosis of the femoral head in children with immune kidney disease
Authors: Liu Jiao , Liu Shaoshan , Su Yuxi 
Published: January 2025

Abstract

Objective
To investigate the risk factors for steroid-induced osteonecrosis of the femoral head (SONFH) after glucocorticoid (GC) therapy in children with immune kidney diseases.

Methods
This retrospective study included patients (1–18years) diagnosed with immune kidney disease treated with GCs from January 2012 to July 2022 in our hospital. Data, such as sex, age and body weight at the first GC treatment, and the GC dose, were collected. Patients were divided into SONFH and non-SONFH groups based on the occurrence of SONFH. According to the International Classification of Diseases (ICD-10), the disease diagnosis was searched on the clinical data webpage of our hospital. The descriptive statistics and binary logistic regression analyses were performed. A nomogram was constructed to predict the risk of SONFH in children with immune kidney disease after GC treatment. The predictive ability of the nomogram was evaluated using the concordance index and calibration plots.

Results
The SONFH and non-SONFH groups included 18 and 90 patients, respectively. Age at the first GC treatment, the six-month cumulative (oral [po.] plus intravenous [iv.]) GC dose, the total cumulative prednisone (po.) dose, total cumulative methylprednisolone (iv.) dose for pulse therapy, and total cumulative GC (po. plus iv.) dose significantly differed between the two groups. Age at the initial GC treatment, the total cumulative prednisone (po.) dose, and the total cumulative methylprednisolone (iv.) dose for pulse therapy were independent risk factors for SONFH in the multivariate analysis.

Conclusions
This study identified specific risk factors for developing SONFH during GC treatment. Thus, children with immune-related kidney disease undergoing GC treatment should be closely monitored based on these risk factors, which aims to avoid the irreversible damage to the femoral head.
Are we ready? assessing effectiveness and implementation of cancer control strategies in primary care: a comprehensive review of systematic reviews
Authors: Martinez-Gutierrez Javiera , Soto María Gabriela , Rioseco Andrea , Bienzobas Catalina , Fowler Madeline , Ulloa Gonzalo , Soto Mauricio , Emery Jon David , Puschel Klaus 
Published: January 2025

Abstract

Background
Cancer is a major global cause of death, and primary care is crucial for cancer prevention and early detection. However, there is conflicting information on the effectiveness, implementation, and sustainability of cancer control interventions in primary care.

Objective
This study aimed to summarize the evidence for cancer control in primary care, focussing on identifying relevant factors for implementation and sustainability.

Study setting and design
We conducted a narrative, mixed-methods review of systematic reviews, guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Four databases were screened, and two independent reviewers selected studies reporting on cancer prevention, screening, or early detection in primary or community settings. We analysed findings using the extended Reach-Effectiveness-Adopt-Implementation-Maintenance (RE-AIM) Framework.

Principal findings
From the 37 reviews that met the inclusion criteria, 6 focussed on primary prevention, 23 on screening, and 12 on early detection. Most reviews (78%) addressed intervention effectiveness, such as HPV vaccination, tobacco cessation, and cervical, breast, and colorectal screening. One-third of the reviews mentioned adoption and implementation factors, including barriers and facilitators to the implementation of cancer screening programs. Only one review addressed maintenance and sustainability factors, exploring continuous resources and funding strategies.

Conclusion
While numerous interventions are effective for cancer prevention and detection in primary care, literature on implementation and sustainability strategies is lacking. Focusing on continuous resources and funding for cancer strategies in primary care may aid sustainability. Future research should prioritize reporting on implementation and sustainability factors to enhance cancer prevention and control in primary care settings.
Dynamics of fungal endophytic communities in bilberry (Vaccinium myrtillus L.) fruits through development is shaped by host phenolic compounds
Authors: Nguyen Minh-Phuong , Lehosmaa Kaisa , Martz Françoise , Koskimäki Janne J , Toth Katalin , Ahonen Saija H K , Häggman Hely , Pirttilä Anna-Maria 
Published: January 2025

Abstract
The physical and chemical properties of wild berry fruits change dramatically during development, and the ripe berries host species-specific endophytic communities. However, the development of fungal endophytic communities during berry ripening is unknown. We studied bilberries (Vaccinium myrtillus L.), valuable natural resources in northern Europe and richest sources of phenolic compounds, to characterize dynamics of the fungal communities over fruit developmental stages (raw, veraison, and ripe). Our focus was to examine the changes in the fruit phenolic compounds associated with the fungal community structure using liquid chromatography–mass spectrometry for phenolic compounds and high-throughput sequencing technology targeting the internal transcribed spacer 2 ribosomal DNA region for endophytic fungi. We found that the fungal diversity increased with the ripening stages. The fungal profile changed dramatically through fruit development, and the veraison stage was a transition stage, where the core mycobiome of fruits changed. The fungal community structure and abundance of the most dominant genera in raw and ripe stages, Monilinia and Cladosporium, respectively, were driven by the bilberry phenolic profile. We conclude that sampling time, tissue age, and phenolic compounds play important roles in the development of fruit fungal community. Moreover, phenolic compounds could be the host's strategy to recruit beneficial microbes.
Exploring 1-alkene biosynthesis in bacterial antagonists and Jeotgalicoccus sp. ATCC 8456
Authors: Schweitzer Matthias , Friedrich Andrea Marianne , Dennig Alexander , Berg Gabriele , Müller Bogotá Christina Andrea 
Published: January 2025

Abstract
Terminal olefins are important platform chemicals, drop-in compatible hydrocarbons and also play an important role as biocontrol agents of plant pathogens. Currently, 1-alkenes are derived from petroleum, although microbial biosynthetic routes are known. Jeotgalicoccus sp. ATCC 8456 produces 1-alkenes via the fatty acid decarboxylase OleTJE. UndA and UndB are recently identified non-heme iron oxidases converting medium-chain fatty acids into terminal alkenes. Our knowledge about the diversity and natural function of OleTJE, UndA, and UndB homologs is scarce. We applied a combined screening strategy—solid-phase microextraction coupled with gas chromatography–mass spectrometry (SPME GC–MS) and polymerase chain reaction (PCR)-based amplification—to survey an environmental strain collection for microbial 1-alkene producers and their corresponding enzymes. Our results reinforce the high level of conservation of UndA and UndB genes across the genus Pseudomonas. In vivo production of defined 1-alkenes (C9–C13; C15; C19) was directed by targeted feeding of fatty acids. Lauric acid feeding enabled 1-undecene production to a concentration of 3.05 mg l−1 in Jeotgalicoccus sp. ATCC 8456 and enhanced its production by 105% in Pseudomonas putida 1T1 (1.10 mg l−1). Besides, whole genome sequencing of Jeotgalicoccus sp. ATCC 8456 enabled reconstruction of the 1-alkene biosynthetic pathway. These results advance our understanding of microbial 1-alkene synthesis and the underlying genetic basis.
Schlesneria sphaerica sp. nov., a neutrophilic, xylan-degrading planctomycete from a mountain wetland, and emended description of the genus Schlesneria
Authors: Kulichevskaya Irina S , Ivanova Anastasia A , Naumoff Daniil G , Zlatogorskaya Anna A , Kachmazov Gennady S , Dedysh Svetlana N 
Published: January 2025

Abstract
Aerobic chemoorganotrophic planctomycetes of the genus Schlesneria colonize a wide spectrum of freshwater ecosystems. The only described species of this genus, S. paludicola, is represented by ellipsoid-shaped, moderately acidophilic bacteria isolated from acidic peat bogs. Here, we characterize a novel neutrophilic member of this genus from a mountain wetland, strain T3-172T. This isolate possesses unpigmented, non-motile, spherical cells, which grow on media containing some mono- and polysaccharides in the pH range of 6.0–7.5 and at temperatures between 15 and 37°C. Good growth is observed on xylan, one of the major plant cell wall biopolymers. The genome of strain T3-172T is 7.16 Mb in size and contains two unlinked sets of rRNA genes, 93 tRNA genes, and about 5500 potential protein-coding genes. Among the latter, the GH5 family protein is identified as the most reliable candidate for the cleavage of xylan. The 16S rRNA gene sequence of strain T3-172T displays 97.8% similarity to that of S. paludicola MPL7T, and the average nucleotide identity between the genomes of these planctomycetes is 71.6%. We, therefore, propose a novel species of the genus Schlesneria, S. sphaerica sp. nov., with strain T3-172T (=KCTC 102306T = VKM B-3856T) as the type strain.
Prosocial Intentions and Subsequent Cognitive Health: A Prospective Cohort Study
Authors: Farmer Justin G , Macchia Lucía , Bu Feifei , Gong Jessica , Steptoe Andrew , Demakakos Panayotes , Kubzansky Laura D 
Published: January 2025

Abstract

Objectives
Prosociality, defined as positive other-regarding intentions and behaviors, is a modifiable factor demonstrated to be associated with better mental, physical, and cognitive health in older adults. Prior studies have largely focused on individual prosocial behaviors, especially volunteering. This study examines whether prosocial intentions are associated with maintaining cognitive health over time.

Methods
Data are from 7,844 adults aged 50 or older in the English Longitudinal Study of Ageing. A 9-item prosocial intentions scale was derived from self-reported items assessing altruism and collectivism. Cognitive health was assessed via biennial completion of tasks related to executive function and verbal memory and incident dementia diagnosis over 11 years. Linear mixed-effects models examined relationships between prosocial intentions and changes in executive function and verbal memory. Cox proportional hazards models assessed risk of developing dementia. A broad array of demographic, socioeconomic, and health-related covariates were also considered.

Results
Results from mixed-effects analyses suggest higher prosocial intentions are associated with better cognitive health maintenance after controlling for sociodemographics and baseline health characteristics including depressive symptoms. Participants with high versus low prosocial intentions had 24% slower decline in verbal memory and 55% slower decline in executive function. Similarly, higher prosocial intentions were associated with a 35% reduced hazard of dementia during this same period in fully adjusted models.

Discussion
These results suggest aspects of prosociality beyond formal volunteering facilitate maintaining cognitive health among older adults and may provide novel targets for future interventions to enhance healthy aging.
Making sense of sentinels: wildlife as the One Health bridge for environmental antimicrobial resistance surveillance
Authors: Doyle Caoimhe , Wall Katie , Fanning Séamus , McMahon Barry J 
Published: January 2025

Abstract
Antimicrobial resistance (AMR), arising from decades of imprudent anthropogenic use of antimicrobials in healthcare and agriculture, is considered one of the greatest One Health crises facing healthcare globally. Antimicrobial pollutants released from human-associated sources are intensifying resistance evolution in the environment. Due to various ecological factors, wildlife interact with these polluted ecosystems, acquiring resistant bacteria and genes. Although wildlife are recognized reservoirs and disseminators of AMR in the environment, current AMR surveillance systems still primarily focus on clinical and agricultural settings, neglecting this environmental dimension. Wildlife can serve as valuable sentinels of AMR in the environment, reflecting ecosystem health, and the effectiveness of mitigation strategies. This review explores knowledge gaps surrounding the ecological factors influencing AMR acquisition and dissemination in wildlife, and highlights limitations in current surveillance systems and policy instruments that do not sufficiently address the environmental component of AMR. We discuss the underutilized opportunity of using wildlife as sentinel species in a holistic, One Health-centred AMR surveillance system. By better integrating wildlife into systematic AMR surveillance and policy, and leveraging advances in high-throughput technologies, we can track and predict resistance evolution, assess the ecological impacts, and better understand the complex dynamics of environmental transmission of AMR across ecosystems.
On Nilpotent Minimum logics defined by lattice filters and their paraconsistent non-falsity preserving companions
Authors: Gispert Joan , Esteva Francesc , Godo Lluís , Coniglio Marcelo E 
Published: January 2025

Abstract
Nilpotent Minimum logic (NML) is a substructural algebraizable logic that is a distinguished member of the family of systems of Mathematical Fuzzy logic, and at the same time it is the axiomatic extension with the prelinearity axiom of Nelson and Markov’s Constructive logic with strong negation. In this paper our main aim is to characterize and axiomatize paraconsistent variants of NML and its extensions defined by (sets of) logical matrices over linearly ordered NM-algebra with lattice filters as designated values, with special emphasis on those that only exclude the falsum truth-value, called non-falsity preserving logics. We also consider turning these non-falsity preserving logics into Logics of Formal Inconsistency by expanding them with a consistency operator, and we axiomatize them as well. Finally, we provide a full description of the logics defined by finite products of matrices over finite NM-chains.
Kifunensine-sensitive ADP-ribosylation factor A1E
G69R mutant reveals coordination of protein glycosylation and vesicle transport pathways
Authors: Nagashima Yukihiro , Sharma Vinita , Reekers Lea-Franziska , von Schaewen Antje , Koiwa Hisashi 
Published: January 2025

Abstract
Complex N-glycans are asparagine (N)-linked branched sugar chains attached to secretory proteins in eukaryotes. They are produced by modification of N-linked oligosaccharide structures in the endoplasmic reticulum and Golgi apparatus. Complex N-glycans formed in the Golgi apparatus are often assigned specific roles unique to the host organism, with their roles in plants remaining largely unknown. Using inhibitor (kifunensine, KIF) hypersensitivity as read out, we identified Arabidopsis mutants that require complex N-glycan modification. Among &gt;100 KIF-sensitive mutants, one showing abnormal secretory organelles and a salt-sensitive phenotype contained a point mutation leading to amino acid replacement (G69R) in ARFA1E, a small Arf1-GTPase family protein presumably involved in vesicular transport. In vitro assays showed that the G69R exchange interferes with protein activation. In vivo, ARFA1EG69R caused dominant-negative effects, altering the morphology of the endoplasmic reticulum, Golgi apparatus, and trans-Golgi network (TGN). Post-Golgi transport (endocytosis/endocytic recycling) of the essential glycoprotein KORRIGAN1, one of the KIF sensitivity targets, is slowed down constitutively as well as under salt stress in the ARFA1EG69R mutant. Because regulated cycling of plasma membrane proteins is required for stress tolerance of the host plants, the ARFA1EG69R mutant established a link between KIF-targeted luminal glycoprotein functions/dynamics and cytosolic regulators of vesicle transport in endosome-/cell wall-associated tolerance mechanisms.
Evolution of parsec-scale jet directions in active galaxies
Authors: Kostrichkin I M , Plavin A V , Pushkarev A B , Butuzova M S 
Published: January 2025

Abstract
We analyze the variability of the parsec-scale jet directions in active galactic nuclei (AGNs). Our analysis involves 317 AGNs at frequencies ranging from 2 to 43 GHz, and is made possible by developing an automatic jet direction measurement procedure. We find strong significant variations in a one quarter of these AGNs; the effect is likely ubiquitous, and not detected in the rest due to a limited sensitivity and observations epoch coverage. Apparent jet rotation speeds range from 0.21 deg yr−1 at 2 GHz to 1.04 deg yr−1 at 43 GHz. This strong frequency dependence indicates that the variability cannot be explained by jet components propagating ballistically without acceleration: more complex jet shapes or motion patterns are required. Still, we demonstrate that the apparent direction changes are predominantly caused by the jet nozzle rotations, and not by individual components propagating transversely to the jet. In this work, we focus on variability scales much longer than the times of observations, that is ≳ 50 years. Using our measurements, we bound potential periods to less than 1000 years in the source rest frame for 90% AGNs in the sample. These timescales constrain jet direction variation mechanisms, with the most likely explanations being the plasma instabilities, the precession caused by the accretion disk with density ∼r−1, and the orbital motion of binary systems.
High-resolution isotopic data link settlement complexification to infant diets within the Roman Empire
Authors: Cocozza Carlo , Harris Alison J T , Formichella Giulia , Pedrucci Giulia , Rossi Paola F , D’Alessio Alessandro , Amoretti Valeria , Zuchtriegel Gabriel , O’Reilly Michelle , Mantile Noemi , Panella Sofia , Tafuri Mary A , Altieri Simona , di Cicco Maria R , Fernandes Ricardo , Lubritto Carmine 
Published: January 2025

Abstract
Our study explores the potential relationship between infant feeding practices and settlement complexity in the Roman Empire through high-resolution Bayesian-modeled stable isotope measurements from incremental dentine. We compiled isotopic data from permanent first molars of individuals from various Roman sites: five from Bainesse (UK), 30 from Thessaloniki (Greece), along with new carbon and nitrogen isotope analyses from four individuals from Pompeii and six from Ostia Via del Mare (AVM). Our results reveal significant inter-site variability in breastfeeding durations, ranging from 1.5 years to approximately 5 years. Notably, individuals from the highly complex urban centers of Pompeii and Thessaloniki ceased breastfeeding around or below the 2-year weaning threshold recommended by Roman physicians. In contrast, individuals from the rural site of Ostia AVM and the site of Bainesse, near the northern frontier of the Roman Empire, generally ceased breastfeeding after 2 years of age. The link between settlement complexity and duration of breastfeeding observed in our study may have resulted from adherence to medical guidelines, support infrastructures, and/or strategies to mitigate financial constraints within households.
Molecular and clinical traits of HER2-low breast cancer patients and their relationship with neoadjuvant treatment effectiveness
Authors: Zhao Wei , Zhang Mingxiang , Zhu Bohui , Pan Yueyin , Sun Yiyuan 
Published: January 2025

Background
We aimed to investigate the clinical and molecular characteristics of different degrees of human epidermal growth factor receptor 2 (HER2) protein expression in HER2-negative breast cancer and the related factors affecting the efficacy of neoadjuvant chemotherapy in HER2-low breast cancer patients.

Methods
The study endpoint was pathological complete remission (PCR). Blood specimens and fresh cancer tissue samples were collected before neoadjuvant chemotherapy for whole-exon sequencing (WES) and RNA sequencing (RNA-seq), and patients were divided into a human epidermal growth factor receptor 2 (HER2)-low group and a HER2-0 group according to their HER2 expression status via bioinformatics analysis.

Results
A total of 409 HER2-negative breast cancer patients were included in the analysis, and HER2 status (HER2-0 vs. HER2-low) was significantly different between hormone receptor status, the Ki-67 index, and the PCR rate. A total of 18 patients who underwent WES and RNA testing were included, and the WES results suggested that the HER2-low group had a significantly higher rate of PIK3CA mutations and a greater frequency of PI3K pathway variants than the other groups and the HER2-low group had a greater number of concomitant mutations and reached statistical significance (P = 0.03). In terms of expression profiles, HER2-low and HER2-0 patients had different expression profiles. Overall, suggesting that the low PCR rate in the HER2-low group may also be related to chemoresistance.

Conclusion
Our investigation highlights the possibility that HER2-low breast cancer may indicate a unique clinical and biological phenomenon.