bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non‐Invasive Detection, Precise Localization, and Perioperative Navigation of In Vivo Deep Lesions Using Transmission Raman Spectroscopy
Authors: Wu Zongyu , Deng Binge , Zhou Yutong , Xie Haoqiang , Zhang Yumin , Lin Li , Ye Jian 
Published: June 2023

AbstractNon‐invasive detection and precise localization of deep lesions have attracted significant attention for both fundamental and clinical studies. Optical modality techniques are promising with high sensitivity and molecular specificity, but are limited by shallow tissue penetration and the failure to accurately determine lesion depth. Here the authors report in vivo ratiometric surface‐enhanced transmission Raman spectroscopy (SETRS) for non‐invasive localization and perioperative surgery navigation of deep sentinel lymph nodes in live rats. The SETRS system uses ultrabright surface‐enhanced Raman spectroscopy (SERS) nanoparticles with a low detection limit of 10 pM and a home‐built photosafe transmission Raman spectroscopy setup. The ratiometric SETRS strategy is proposed based on the ratio of multiple Raman spectral peaks for obtaining lesion depth. Via this strategy, the depth of the phantom lesions in ex vivo rat tissues is precisely determined with a mean‐absolute‐percentage‐error of 11.8%, and the accurate localization of a 6‐mm‐deep rat popliteal lymph node is achieved. The feasibility of ratiometric SETRS allows the successful perioperative navigation of in vivo lymph node biopsy surgery in live rats under clinically safe laser irradiance. This study represents a significant step toward the clinical translation of TRS techniques, providing new insights for the design and implementation of in vivo SERS applications.
Phenotype–fitness relationships and pollen‐transfer efficiency of five orchid species with different pollination strategies
Authors: Capó Miquel , Borràs Joshua , Perelló‐Suau Sebastià , Rita Juan , Cursach Joana 
Published: June 2023

AbstractPremiseDeceptive pollination, a fascinating mechanism that independently originated in several plant families for benefiting from pollinators without providing any reward, is particularly widespread among orchids. Pollination efficiency is crucial in orchids due to the aggregated pollen in a pollinarium, which facilitates pollen transfer and promotes cross‐pollination as pollinators leave after being deceived.MethodsIn this study, we compiled data on reproductive ecology from five orchid species with different pollination strategies: three deceptive‐strategy species (shelter imitation, food deception, sexual deception), one nectar‐rewarding species, and one shelter‐imitation but spontaneously selfing species. We aimed to compare the reproductive success (female fitness: fruit set; male fitness: pollinarium removal) and pollination efficiency of species representing these strategies. We also investigated pollen limitation and inbreeding depression among the pollination strategies.ResultsMale and female fitness were strongly correlated in all species but the spontaneously selfing species, which had high fruit set and low pollinarium removal. As expected, pollination efficiency was highest for the rewarding species and the sexually deceptive species. Rewarding species had no pollen limitation but did have high cumulative inbreeding depression; deceptive species had high pollen limitation and moderate inbreeding depression; and spontaneously selfing species did not have pollen limitation or inbreeding depression.ConclusionsPollinator response to deception is critical to maintain reproductive success and avoid inbreeding in orchid species with non‐rewarding pollination strategies. Our findings contribute to a better understanding of the trade‐offs associated with different pollination strategies in orchids and highlight the importance of pollination efficiency in orchids due to the pollinarium.
Alkoxymigration onto α‐Imino Gold Carbenes for Constructing Propellane‐Type Indolines
Authors: Greiner Luca C. , Arichi Norihito , Inuki Shinsuke , Ohno Hiroaki 
Published: June 2023

AbstractWe developed a new reaction entity of α‐imino gold carbenes involving alkoxy migration. The reaction would proceed through oxonium ylide formation by intramolecular addition of an alkoxy group, carbon‐oxygen bond cleavage, and carbon−carbon bond formation. We achieved an efficient gold‐catalyzed synthesis of indoline‐propellanes via a one‐pot sequence by using ethylene glycol as a trapping reagent.
The mechanical properties of polystyrene composites were improved by designing large‐size 3D GO/CNTs hybrid aerogel reinforced by epoxy resin
Authors: Xu Hui , Sun Yanzeng , Song Guojun , Song Yinghu , Li Jialing , Wu Jinzhe , Guo Cong , Li Xiaoru 
Published: June 2023

AbstractDispersion of carbon nanomaterials in polymers has long been a challenge. In this work, large‐scale epoxy‐reinforced GO/CNT aerogel (GECA) was prepared with stable three‐dimensional (3D) interconnected network as reinforced skeleton. The GECA/polystyrene (GECA/PS) nanocomposites were then fabricated by in‐situ polymerization of styrene in interconnected GECA. The results showed that the obtained GECA exhibited high compression modulus with no significant permanent deformation. Furthermore, the mechanical properties of the prepared GECA/PS were significantly improved with a low filler content of 1.0 wt.%. when the ratio of GO and CNT to epoxy resin was 1:1, the tensile strength, flexural strength, compressive strength, and impact strength of the composites were the highest, at 17.51 MPa, 33.01 MPa, 110.28 MPa, and 4.169 KJ/m2, respectively, representing an increase of 113.0%, 76.1%, 147.5%, and 99.5%, respectively.
Leveraging a century of fisheries surveys to prioritize conservation efforts for species in Great Plains streams of Oklahoma (USA)
Authors: Starks Trevor A. , Wallace Drew A. , Pallett Matthew S. , Rodger Anthony W. 
Published: June 2023

Abstract

Although non‐game fishes typically dominate lists of threatened and imperilled species, funding mechanisms for non‐game species are usually less robust than those for game species. This imbalance emphasizes the need for methodologies to identify imperilled species effectively and ensure efficient allocation of limited conservation resources.
A database comprising >3,900 fisheries surveys conducted between 1905 and 2020 in Great Plains streams of Oklahoma (USA) was used to develop methodology for identifying species in need of conservation by assessing differences in species occurrences and trends in species ranges through time.
Changes in occurrence for 92 species at both river catchment and ecoregion scales were assessed. Generalized linear models indicated significant differences between historical and contemporary fish communities at both scales. Univariate testing showed 84 instances of species occurrences changing in at least one catchment.
Declines in occurrence were observed for eight species currently listed as species of greatest conservation need in Oklahoma and were used to identify five candidate species for listing. Family‐level trends in species occurrences suggested declines of native true minnow species and increases in generalist sunfishes and catfishes through time.
Trends in detections within each hydrologic unit code sampled were used as a proxy for tracking changes in species range within each catchment. Various species were used as case studies to highlight this method.
The results demonstrate how managers can apply an empirical methodology that extracts information from long‐term datasets to optimize conservation efforts for stream fishes and associated taxa.
Silver‐catalyzed Regioselective Synthesis of N‐aryl‐1H‐pyrazolyl‐substituted Benzenesulfonamides from Ynamides and Pyrazoles
Authors: Karunakar Galla V. , Raju Chittala Emmaniel , Himaja Karra Sai Bhavani Nagasri , Kumar Perla Bharath , Sridhar Balasubramanian 
Published: June 2023

AbstractSilver‐catalyzed N‐aryl‐1H‐pyrazolyl substituted benzenesulfonamide derivatives were obtained regioselectively from ynamides and pyrazoles. In this intermolecular organic transformation, several substituted benzenesulfonamides were obtained in good to excellent yields by forming a new C−N bond under mild reaction conditions.
Highly microporous and mesoporous nanomaterials derived from Agave sisalana waste for supercapacitors
Authors: Kibona Talam E. , Mahushi Debora J. , Shao Godlisten N. 
Published: June 2023

AbstractNanostructured electrodes with large surface area are essential for studying charge storage mechanisms in supercapacitors. Biomass‐based carbonaceous porous electrodes have proven to be good candidates for supercapacitor application. In this study, micropore and mesopore dominated carbon materials derived from Agave sisalana sisal waste were prepared through carbonization and chemical activation with ZnCl2. Scanning electron microscopy, energy‐dispersive X‐ray, transmission electron microscopy, Raman spectroscopy, and X‐ray diffraction studies show that the microstructure and composition of the as‐prepared microporous carbon materials are influenced by adjusting the ZnCl2 to the carbon mass ratio. Sorption studies demonstrated a high Brunauer–Emmett–Teller (BET) surface area of 1464 m2 g−1, type I isotherms for low temperature, type IV at 900 °C, and 99% micropore content in all the samples. The fabricated electrodes exhibited high specific capacitances of 497 F g−1at 5 mV s−1, which is indicative of our carbon materials’ strong potential for use in the production of high‐performance supercapacitors. Specific capacitance increased with increasing micropore surface areas.
Vitelline vascular remnant causing intestinal obstruction in a patient with TARP syndrome
Authors: Omorodion Jacklyn , Tannenbaum Laura , O'Neill John Patrick , Cummings Christy , Wojcik Monica H. 
Published: June 2023

AbstractBackgroundTARP syndrome, characterized by talipes equinovarus, atrial septal defect, Robin sequence, and persistent left superior vena cava, is an X‐linked recessive condition caused by deleterious variants in RBM10. Vitelline vascular remnants (VVR) are a rare vitelline duct anomaly with approximately 26 cases previously reported. There are no previously reported cases of VVRs in patients with TARP syndrome.CaseWe present a male neonate diagnosed with TARP syndrome via trio whole exome sequencing who had classic features of this syndrome, although his course was additionally complicated by feeding intolerance with multiple episodes of abdominal distension. Serial imaging and contrast studies of the upper GI tract and small bowel demonstrated small bowel obstruction of unclear etiology. Given the poor prognosis associated with this condition, life‐sustaining measures were withdrawn, and he passed away at 38 days of age. On autopsy, a VVR was unexpectedly identified with proximal bowel dilation, explaining his feeding intolerance.ConclusionsWe highlight the importance of full post‐mortem examination in understanding the complete spectrum of manifestations of genetic syndromes and provide a review of the literature.
Teaching and assessing undergraduate collaboration skills scaffolded through the biochemistry curriculum using collaboration rubrics and student learning contracts
Authors: Mertz Pamela S. , Sherrer Shanen M. , Bowers Geoffrey M. 
Published: June 2023

AbstractThe Department of Chemistry and Biochemistry at St. Mary's College of Maryland has scaffolded collaboration skills throughout the Biochemistry curriculum and developed several assessment tools to evaluate these skills. Biochemistry I and II have used team contracts at the beginning of extensive team projects where students identify their strengths, review expectations, and plan for group communication. At the conclusion of each project, each student assesses their own contributions and team members for various parts of the project. A common collaboration rubric was also applied in Biochemistry I and II as well as in two other courses, General Chemistry II Lab and Physical Chemistry I Lab, for students to evaluate themself and team members using the following subcategories: quality of work, commitment, leadership, communication, and analysis. In Biochemistry I and II, we used this rubric for multiple assignments that are part of the projects in the lecture courses. In the General Chemistry II Lab, we provided elements of this rubric within an evaluation form that reflects these collaboration attributes after each lab experience, so students can assess and report privately on their experiences as part of their collaboration grade for the course. A similar collaboration rubric is completed by students for each team‐based laboratory within Physical Chemistry I. We also demonstrate different ways that instructors can use the data from these assessment tools. In our department, we are using these tools to frame the importance of collaboration skills and collecting data to inform our teaching of these skills. Preliminary data suggest that our curriculum is successfully teaching students how to be good collaborators.
Blue goes green: The impact of the chief executive officer and board of directors' political ideology on corporate environmental performance
Authors: Kim Yeongsu Anthony 
Published: June 2023

AbstractThis study investigates the association between a CEO's political ideology and Corporate Environmental Performance. Although previous research has established a strong association between a CEO's political ideology and overall performance on Corporate Social Responsibility, little research has examined how it relates to a firm's environmental impact. Utilizing data on CEO political donations, this study shows that a CEO's liberalism generally has a positive effect on a firm's environmental performance. However, this relationship can be influenced by the political conservatism of the board of directors. Furthermore, liberal CEOs are inclined to prioritize environmental strength and minimize environmental concerns. This research provides insight into the intricate dynamics of how a CEO's political ideology, as well as that of the board of directors, can influence a firm's environmental performance.
Nonfinancial reporting in family firms: A systematic review and agenda for future research
Authors: Brunelli Sofia , Sciascia Salvatore , Baù Massimo 
Published: June 2023

AbstractThis paper offers a systematic review of the literature on nonfinancial reporting in family firms, which has substantially grown in recent years. We identified and analyzed 74 articles published between 2002 and 2023. The work contributes to the domains of nonfinancial reporting and family business by providing an integrative and critical overview of the literature and by identifying future research avenues. We conclude by offering practical implications for managers, consultants, and policymakers.
Perforating cutaneous vessels: A key feature of acupoints – Anatomical evidence from five‐Shu acupoints in the upper limbs
Authors: Meng Shuo , Tang Zitian , Zhu Mingsheng , Liang Xinshuo , Ding Zhiwei , Wang Zengtao , Hu Jinlian 
Published: June 2023

AbstractAcupuncture has been proven an effective clinical treatment for numerous pathological conditions and malfunctions. However, substantial anatomical evidence for acupuncture points (APs) and meridians is still lacking, so the location of APs is relatively subjective and understanding of the biological mechanisms of acupuncture is limited. All these problems hinder the clinical applications and worldwide acceptance of acupuncture. Our long‐term microsurgery experience has indicated that Perforating Cutaneous Vessels (PCVs) are highly relevant to APs but the anatomical evidence is insufficient. To address this lack, two specimens of fresh adult human upper limbs were dissected using an advanced vascular perfusion‐fixation method and then examined. The results show that all 30 five‐Shu APs in the upper limbs have corresponding PCVs. Both specimens showed a 100% coincidence rate between APs and PCVs, indicating that PCVs could be critical anatomical features of APs. This study also provides an anatomical basis for locating APs objectively via preliminary detection of PCVs. The findings could lead to a better theoretical understanding of mechanisms of acupuncture and the essence of meridians.
Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma
Authors: Onda Maho , Ota Akinobu , Ito Kunihiro , Ono Takayuki , Karnan Sivasundaram , Kato Mikako , Kondo Sayuri , Furuhashi Akifumi , Hayashi Tomio , Hosokawa Yoshitaka , Kazaoka Yoshiaki 
Published: June 2023

AbstractBackgroundEpidermal growth factor receptor (EGFR) is frequently overexpressed in oral squamous cell carcinoma (OSCC), and EGFR‐targeting therapeutics have been widely employed to treat patients with a variety of carcinomas including OSCC. Here, we aimed to investigate alternative signaling for OSCC survival under the disruption of EGFR signaling.MethodsOSCC cell lines, namely HSC‐3 and SAS, were utilized to investigate how EGFR disruption affects cell proliferation. Gene set enrichment analysis was performed to examine how EGFR disruption affects oncogenic signaling in OSCC cells. Disruption of KDR gene was performed using CRISPR/Cas9 techniques. A VEGFR inhibitor, vatalanib was used to research the impact of VEGFR inhibition on OSCC survival.ResultsEGFR disruption significantly decreased the proliferation and oncogenic signaling including Myc and PI3K‐Akt, in OSCC cells. Chemical library screening assays revealed that VEGFR inhibitors continued to inhibit the proliferation of EGFR‐deficient OSCC cells. In addition, CRISPR‐mediated disruption of KDR/VEGFR2 retarded OSCC cell proliferation. Furthermore, combined erlotinib–vatalanib treatment exhibited a more potent anti‐proliferative effect on OSCC cells, compared to either monotherapy. The combined therapy effectively suppressed the phosphorylation levels of Akt but not p44/42.ConclusionVEGFR‐mediated signaling would be an alternative signaling pathway for the survival of OSCC cells under the disruption of EGFR signaling. These results highlight the clinical application of VEGFR inhibitors in the development of multi‐molecular‐targeted therapeutics against OSCC.
Design and Synthesis of Pyridine and Thiazole Derivatives as Eco‐friendly Insecticidal to Control Olive Pests
Authors: Elkanzi Nadia A. A. , Al‐Hazmi Aryam Khaled Ghayad , Bakr Rania B. , Gad Mohamed A. , Abd El‐Lateef Hany M. , Ali Ali M. 
Published: June 2023

AbstractTreatment of p‐tosyloxybenzaldehyde (1) with ethyl cyanoacetate afforded ethyl 2‐cyano‐3‐(4‐{[(4‐methylphenyl)sulfonyl]oxy}phenyl)acrylate (2) which reacted with some active methylene derivatives under microwave irradiation in presence of ammonium acetate yielded pyridine derivatives 3–7. On the other hand, when treatment of compound 1 with thiosemicarbazide gave 4‐tosyloxybenzylidenethiosemicarbazone (8), which allowed to react with some active methylene compounds, such as: ethyl bromoacetate, chloroacetonitrile or phenacyl bromide derivatives gave thiazole derivatives 9–13. The structure of all products were confirmed by elemental and spectroscopic analyses such as IR, 1H‐NMR, 13CNMR and mass spectra. The advanced of this method are short reaction time (3–7 min), excellent yield, pure products, and low‐cost processing. In the final category, the toxicological characteristics of all compounds were tested towards Saissetia oleae (Olivier, 1791) (Hemiptera: Coccidae). With respect to the LC50 values. It has been found that compound 3 possesses the highest insecticidal bioefficacy compared with other products, with values of 0.502 and 1.009 ppm, for nymphs and adults female, respectively. This study paves the way towards discovering new materials for potential use as insecticidal active agents.
Chemical Analysis and in Vitro Antiviral Effects of Northeast Türkiye Propolis Samples against HSV‐1
Authors: Cora Merve , Buruk C. Kurtuluş , Ünsal Serbülent , Kaklikkaya Neşe , Kolayli Sevgi 
Published: June 2023

AbstractPropolis is one of the mixtures with the widest biological activity among natural products used in complementary medicine. HSV‐1 is a highly contagious and endemic virus. Available drugs are insufficient for recurrent HSV‐1 infections. Therefore, new approaches to treat HSV‐1 infections are still being developed. In this study, it was aimed to investigate the inhibition effect of ethanolic Anatolian propolis extracts obtained from the Eastern Black Sea Region (Pazar, Ardahan, and Uzungöl) on HSV‐1. In addition to the total phenolic (TPC) and the total flavonoid content (TFC), the phenolic profiles of the extracts were analyzed by HPLC‐UV. The antiviral activity of the extracts were tested by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT), quantitative Real Time Polymerase Chain Reaction (qRT‐PCR), and plaque reduction tests, and the results were evaluated statistically. It was determined that the total amount of phenolic substances varied between 44.12 and 166.91 mg GAE/g, and the total flavonoid content of the samples varied between 12.50 and 41.58 (mg QUE/g). It was shown that all propolis samples used in the current study were effective against HSV‐1, but the higher phenolic compounds contained in the samples showed the higher activity. The results show that ethanolic propolis extracts are promising candidates for HSV‐1 treatment.
Dexamethasone to prednisolone rotation relieved hiccups in colorectal cancer patient continuing teleworking during anticancer therapy
Authors: Nagata Takuya , Watanabe Ayako , Momo Kenji , Kashiwabara Yuka , Saeki Misa , Oto Yuji , Uchikura Takeshi , Kobayashi Koji , Toshima Hirokazu , Shimada Ken , Tanaka Katsumi 
Published: June 2023

Key Clinical MessageWe present a case of chemotherapy‐induced hiccups that were alleviated by steroid rotation. Hiccups are often overlooked, but they have an impact on the patient's quality of life. In the COVID‐19 era, web‐based teleworking has become an important tool, hiccups during a teleconference should be noted as a concern for patients.
Extensive chronic perianal pyoderma associated with persistent inflammation caused by wearing the same unwashed underwear for more than ten years
Authors: Adachi Michiko Matsuzawa , Yoshida Katsuyuki , Fukuchi Takahiko , Tanaka Akira , Yamamoto Naoto , Sugawara Hitoshi 
Published: June 2023

Key Clinical MessagePoor personal hygiene wearing the same unwashed briefs, and prolonged sitting have led to the development of chronic perianal pyoderma. This can be confused with hidradenitis suppurativa and must be differentiated as their treatments are different.AbstractThere are potential risks of persistent inflammation resulting from poor personal hygiene. This comprises wearing the same unwashed briefs and prolonged sitting posture that led to developing chronic perianal pyoderma (CPP) in a smoking man. CPP can be confused with hidradenitis suppurativa, requiring differentiation as their treatment strategies distinctly differ.