bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between recorded loneliness and adverse mental health outcomes among patients receiving mental healthcare in South London: A retrospective cohort study
Authors: Parmar Mayur , Ma Ruimin , Attygalle Sumudu , Herath Deepika , Mueller Christoph , Stubbs Brendon , Stewart Robert , Perera Gayan 
Published: April 2023

Abstract
Purpose Loneliness disproportionately affects people with mental disorders, but associations with mental health outcomes in groups affected remain less well understood.Method A cohort of patients receiving mental healthcare on 30th June 2012 was assembled from a large mental health records database covering a south London catchment area. Recorded loneliness within the preceding 2 years was extracted using natural language processing and outcomes were measured between 30th June 2012 until 30th December 2019, except for survival which applied a censoring point of 6th December 2020 according to data available at the time of extraction. The following mental healthcare outcomes: i) time to first crisis episode; ii) time to first emergency presentation; iii) all-cause mortality; iv) days active to service per year; and v) face-to-face contacts per year.Results Loneliness was recorded in 4,483 (16.7%) patients in the study population and fully adjusted models showed associations with subsequent crisis episode (HR 1.17, 95% CI 1.07–1.29), emergency presentation (HR 1.30, 1.21–1.40), days active per year (IRR 1.04, 1.03–1.05), and face-to-face contacts per year (IRR 1.28, 1.27–1.30). Recorded loneliness in patients with substance misuse problems was particularly strongly associated with adverse outcomes, including risk of emergency presentation (HR 1.68, 1.29–2.18) and mortality (HR 1.29, 1.01–1.65).Conclusion Patients receiving mental healthcare who are recorded as lonely have a higher risk of several adverse outcomes which may require a need for higher service input.
Recodification of the Latin American City: Emerging Urban Legislation in the Pandemic Era
Authors: Pichihua Yeimis 
Published: April 2023

In recent years, urban policies have been transformed in response to the pandemic. The new normality has translated into a new urbanity, in the broadest sense of the word; that is, into new rules that shape daily life and the production of urban space itself. However, in Latin America, most of these measures have been contingent on the emergency, as they have not been translated into structural or long-term policies.
This research focuses on the changes experienced in urban legislation as of 2020. Period where national governments had to simultaneously confront health problems and pre-existing urban dysfunctionalities. This is a descriptive study outlining the landscape of emerging urban policies. It focuses on visible changes at the Latin American level,
The results reveal that many Latin American countries have changed their urban policies during the pandemic, including a growing interest in social housing. Among the issues addressed are land regulation, the right to the city, the management of public spaces, informal settlements, etc. In conclusion, the pandemic was the scene of a change of course based on new urban policies. These policies improve the management of our cities and make it possible to build more sustainable and equitable spaces.
The Effects of Scheduled Smoking Reduction and Precessation Nicotine Replacement Therapy on Smoking Cessation: Randomized Controlled Trial With Compliance
Authors: Cinciripini Paul M , Minnix Jennifer A , Robinson Jason D , Kypriotakis George , Cui Yong , Blalock Janice A , Lam Cho Y , Wetter David W 
Published: April 2023

Background
Smoking remains a major public health problem, and it is important to provide a variety of efficacious and appealing options to encourage smokers to quit smoking. Scheduled smoking is a method of gradual reduction, preparing smokers to quit by systematically reducing cigarette consumption according to a predetermined schedule that increases the time between cigarette consumption. Gradual reduction may be preferred to abrupt quitting, but the efficacy of this cessation approach is unclear.

Objective
This study aims, first, to evaluate the overall effectiveness of scheduled smoking alone, or in combination with precessation nicotine replacement therapy (NRT), versus standard NRT starting on the quit date with no prior smoking reduction and, second, to evaluate the impact of schedule compliance on the effectiveness of the intervention.

Methods
A total of 916 participants recruited from the Houston metropolitan area were randomly assigned to 1 of the following 3 groups: scheduled smoking plus a precessation nicotine patch (n=306, 33.4%), scheduled smoking only with no precessation patch (n=309, 33.7%), and enhanced usual care (n=301, 32.9%) control. The primary abstinence outcomes were carbon monoxide–verified, self-reported, 7-day point prevalence abstinence at 2 and 4 weeks after the quit date. Unadjusted and adjusted logistic regression analyses were performed to evaluate the intervention effect. Scheduled smoking was implemented using a handheld device for 3 weeks before quitting. This trial was not registered because data collection began before July 1, 2005.

Results
Results for the first aim showed no overall differences in abstinence among the 3 groups in both the unadjusted and adjusted models. However, the results for the second aim showed a clear effect on abstinence by schedule compliance at 2 and 4 weeks and 6 months after quitting (odds ratio [OR] 2.01, 95% CI 1.31-3.07), 4 weeks (OR 1.58, 95% CI 1.05-2.38), and 6 months (OR 1.68, 95% CI 1.04-2.64), with the differences at 2 and 4 weeks after quitting being the most robust. We also found that scheduled smoking was related to a reduction in nicotine withdrawal, negative affect, and craving when compared with the controls.

Conclusions
Scheduled smoking, when combined with precessation use of NRT, can result in significantly higher abstinence rates than usual care (abrupt quitting with NRT), particularly in the early postquit phase (2 and 4 weeks after cessation) when smokers are compliant with the procedure. Scheduled smoking also produced a better overall quitting experience by reducing symptoms of nicotine withdrawal and craving, in comparison with usual care, which could encourage future quit attempts. Studies in this area should focus on the use of counseling or other methods to improve adherence.
A Comprehensive Self-Management Intervention for Inflammatory Bowel Disease (CSM-IBD): Protocol for a Pilot Randomized Controlled Trial
Authors: Kamp Kendra , Clark-Snustad Kindra , Yoo Linda , Winders Samantha , Cain Kevin , Levy Rona L , Dey Neelendu , Lee Scott , Keefer Laurie , Heitkemper Margaret 
Published: April 2023

Background
Despite pharmacological treatment, individuals with inflammatory bowel disease (IBD) experience a variety of symptoms, including abdominal pain, fatigue, anxiety, and depression. Few nonmedical self-management interventions are available for people with IBD. A validated comprehensive self-management (CSM) intervention is effective for patients with irritable bowel syndrome who can have symptoms similar to those of individuals with IBD. We created a modified CSM intervention tailored to individuals with IBD (CSM-IBD). The CSM-IBD is an 8-session program delivered over 8-12 weeks with check-ins with a registered nurse.

Objective
The primary objective of this pilot study is to determine the feasibility and acceptability of study procedures and the CSM-IBD intervention and to evaluate preliminary efficacy on quality of life and daily symptoms for a future randomized controlled trial. Additionally, we will examine the association of socioecological, clinical, and biological factors with symptoms at baseline and response to intervention.

Methods
We are conducting a pilot randomized controlled trial of the CSM-IBD intervention. Participants aged 18-75 years who are experiencing at least 2 symptoms are eligible for inclusion. We plan to enroll 54 participants who will be randomized (2:1) into the CSM-IBD program or usual care. Patients in the CSM-IBD program will have 8 intervention sessions. Primary study outcomes include the feasibility of recruitment, randomization, and data or sample collection, as well as the acceptability of study procedures and interventions. Preliminary efficacy outcome variables include quality of life and symptoms. Outcomes data will be assessed at baseline, immediately post intervention, and 3 months post intervention. Participants in the usual care group will have access to the intervention after study participation.

Results
This project is funded by the National Institutes of Nursing Research and reviewed by the University of Washington’s institutional review board. Recruitment began in February 2023. As of April 2023, we have enrolled 4 participants. We expect the study to be completed by March 2025.

Conclusions
This pilot study will evaluate the feasibility and efficacy of a self-management intervention (a web-based program with weekly check-ins with a registered nurse) that aims to improve symptom management in individuals with IBD. In the long term, we aim to validate a self-management intervention to improve patient quality of life, reduce direct and indirect costs related to IBD, and be culturally appropriate and accessible, particularly in rural and underserved communities.

Trial Registration
ClinicalTrials.gov NCT05651542; https://clinicaltrials.gov/ct2/show/NCT05651542

International Registered Report Identifier (IRRID)
PRR1-10.2196/46307
Pemodelan protein dan analisis molecular docking enzim β-glukanase solat Bacillus subtilis W3.15
Authors: Hanifitri Ainia , Ambarsari Laksmi , Mubarik Nisa Rachmania 
Published: April 2023

The β-glucanase enzyme is an enzyme protein that can hydrolyze β-glucan, one of the main components of the fungal cell wall. This enzyme protein is produced by several bacteria, one of which is B. subtilis. The three-dimensional (3D) structure of proteins is necessary to understand their properties and functions of proteins. Enzyme proteins can be analyzed for their structure and function using in silico method. This study aims to detect the β-glucanase gene from B. subtilis W3.15 and analyze it using the in silico method. The methods in this research are homology modeling and molecular docking analyses. Modeling was carried out using the SWISS-MODEL server and docking analysis using the PLANTS 1.1 program. Modeling the β-glucanase enzyme is based on the template of the β-glucanase enzyme protein model with PDB code 3o5s. The results of sequence alignment and model visualization were quite good as indicated by the model having a Ramachandran Plot value in the favored area of 91.10 %, a MolProbity score of 0.95, and a QMEAN value of 0.90 ± 0.06. The β-glucanase enzyme model was then docked using the PLANTS1.1 program with native ligand B3P, 1,4-β-D-Glucan, D-glucose, β-D-Glucan from oats, and N-Acetyl glucosamine. The results of docking analysis showed that the β-glucan ligand (β-D-glucan from oats) used as a substrate in the cultivation of isolate B. subtilis W3.15 had a better binding energy prediction value compared to the B3P ligand, which is a natural ligand in the template proteins.

[Keywords: β-Glucan, β-D-Glucan from oat, ligand, PLANTS 1.1, 3D structure, SWISS-MODEL]
Potensi ekstrak kasar metabolit sekunder yang dihasilkan Trichoderma asperellum dan Pseudomonas fluorescens untuk pengendalian antraknosa pada buah kakao
Authors: Matondang Christina Oktora , Muklasin  , Soesanto Loekas 
Published: April 2023

Cocoa pod anthracnose is an important disease of cocoa and can reduce yields. Many attempts have been made to control anthracnose rot disease on cocoa pods but have not been successful yet. This study aimed to examine the potency of secondary metabolite crude extracts produced by Trichoderma asperellum and Pseudomonas fluorescens solely or in combination in controlling anthracnose rot disease of cocoa pods in the field at Silo Bonto Village, Asahan Regency, North Sumatera Province. The secondary metabolite crude extracts was prepared by the form of conidia or T. asperellum and P. fluorescens cells. A randomized block design was used to assessed four treatments i.e. T. asperellum + P. fluorescens, T. asperellum, P. fluorescens secondary metabolite crude extracts and control, which was repeated six times. The observation parameters were the percentage of healthy and diseased pods (anthracnose fruit rot). The results showed that the secondary metabolite crude extracts of T. asperellum, P. fluorescens, and T. asperellum + P. fluorescens reduced the number of diseased fruits by 94.71, 89.09, and 92.09% compared to the control respectively. The increasing of healthy fruits number in the application of secondary metabolite crude extracts of T. asperellum, P. fluorescens, and T. asperellum + P. fluorescens was 52.68, 54.20, and 54.18%, respectively.
Analysis of HOT Content in the Integrated Thematic Students’ and Teachers’ Handbook of the 2013 Curriculum
Authors: Arifin Tiyas , Mustadi Ali , Zulfiati Heri Maria , Fathoni Anang 
Published: April 2023

Higher-order thinking skills (HOTs) are becoming an important skill in today's era. Students’ and teachers’ handbook should have HOT content. This study aims to analyze HOT content in the analysis aspect, evaluation aspect, and creating aspect in the students' and teachers' handbook of the 2013 curriculum on the fifth theme of the third grade. This research used a qualitative approach and content analysis methods. The object was HOT content. Data collection techniques used documentation by reading and taking notes carefully. Validity used semantic validity and reliability used stability and reproducibility. Data analysis techniques consisted of unitizing, sampling, recording/coding, reducing, inferring, and narrating. The findings showed that HOT content has already appeared, but the distribution was not equal. The analysis aspect mostly appears through various questions that can stimulate students' thinking. In evaluation aspect, mostly appears through activities at the end of the lesson. In the creation aspect, most students are commanded to be creative to solve the problem. The result of this study can be used as information for teachers in preparing learning activities by focusing on students' higher-order thinking skills.
ANALISIS KOREOGRAFI TARI PEUMULIA JAMEE CIPTAAN YUSLIZAR SEBAGAI TARI PENYAMBUTAN DI SANGGAR CUT NYAK DHIEN PROVINSI ACEH
Authors: Dewita Aagnes , Indah Putri 
Published: April 2023

Tujuan penelitian ini mengkaji tentang analisis koreografi Tari Peumulia Jamee diciptaan Yulizar, seorang koreografer yang berasal dari Sanggar Cut Nyak Dhien Banda Aceh. Tari ini termasuk ke dalam tari kreasi yang diperoleh dari pengembangan gerak dasar Tari Ranup Lampuan bertujuan memuliakan tamu dengan menyampaikan seserahan atau suguhan kepada tamu. Sal Murgianto (1983: 10): terdapat Prinsip bentuk koreografi meliputi: Unity (kesatuan yang utuh), Variation (variasi), Repetisi (pengulangan), Contras (Kontras) Transition (transisi), Squence (urutan), Climax (klimaks), Balance (keseimbangan), Harmony (harmoni). Metode penelitian ini menggunakan deskriptif kualitatif yang mampu menggali lebih dalam mengenai informasi terkait dengan fakta yang sesuai dilapangan. Pengumpulan data melalui adanya studi kepustakaan, observasi, wawancara hingga ketahap dokumentasi. Hasil penelitian ini diantaranya adalah: : Unity (kesatuan yang utuh)yaitu perpaduan ragam 13 gerak, busana, properti, musik pengiring secara utuh. Variation (keragaman) pada Tari Peumulia Jamee adalah berjumlah 13 ragam gerak yaitu (Ragam 1Pembuka, ragam 2 Langkah Tekuk, ragam 3 Jak Suroet, ragam 4 Ukeu Ngoen, ragam 5 Ek Troen, ragam 6 Wie Neun Simpuh, ragam 7 Jak Berimpuh, ragam 8 Bagah, ragam 9 Wie Neun Bagah, ragam 10 Langkah tekuk, ragam 11 Horeumat, ragam 12 Suroet Horeumat, ragam 13 Peneutoep). Adanya Repetisi (pengulangan) yang terdapat pada 4 ragam yaitu : ragam pembuka berpasangan dengan Peneutoep, dan ragam langkah tekuk berpasangan dengan ragam Bagah. Pada Contras (Kontras) terdapat pada ragam 1 Pembuka dengan ragam 6 Wie Sempuh dan ragam 1 Pembuka dengan ragam 13 Peunutup. Tari Peumulia Jamee tidak memiliki Transition (transisi). Terdapat 5 ragam gerak Squence (urutan) yaitu terdapat pada ragam (1 ragam Pembuka dan 2 ragam Langkah Tekuk, 3 ragam Jak Suroet, 4 ragam Ukue Ngoen, 7 ragam Jak Berimpuh, 11 ragam Horeumat). Climax (klimaks) terdapat pada ragam ke 13 yaitu Peneutup. Balance (keseimbangan) terdapat pada keseluruhan gerak Tari Pemulia Jamee sangat seimbang,kompak. Sedangkan Harmony (harmoni) terdapat pada ragam gerak hormat yang melambangkan kesantunan para perempuan Aceh. Sehingga tari ini juga disebut dengan tari penyambutan terdapat penyuguhan makanan untuk tamu yang sedang berkunjung ke tanah Aceh, hal ini memberikan pituah agar hidup menebarkan kebaikan dengan cara bertingkah sopan dan santun, mengasihi dan saling menghormati sesama manusia.
Chemical and Biological Properties of Potted-Soil for Strawberry Cultivation
Authors: Hindersah Reginawanti , Kamaluddin Nadia Nuraniya , Akustu Masako , Herdiyantoro Diyan 
Published: April 2023

Strawberries in tropical West Java are cultivated intensively in potted soil but the substrate condition received less attention. The objective of this descriptive research was to evaluate the chemical and macronutrient profile in potted-soils for strawberry cultivation, and to determine beneficial microbes’ population in root-free bulk soil and rhizosphere of potted-strawberry. The soil samples collected from 12-months and one-month-old potted strawberry; both contained Inceptisols soil order with 10 t/ha and 25 t/ha manure respectively. The proximate analysis was performed using Association of Official Analytical Chemists Method. The microbial enumeration was performed by Serial Dilution Plate Method in specific medium. The results showed that potted soils were not saline, but slightly acid, low in organic carbon and high in cation exchange capacity. The soil reactions were suitable for strawberry but the electrical conductivity was too low for strawberry growth. The potted soils have low to very low carbon to nitrogen ratio, but high in total nitrogen and very high in potential P2O5 and K2O. The population of phosphate-solubilizing bacteria, nitrogen-fixing Azotobacter, total bacteria and total fungi in old potted soil were low; but its counts were increased in manure-treated potted soil. The ratios of bulk soil to rhizosphere microbial count were only 1.0-1.25. The study verified that the doses of organic matter should be increased, while decreasing the chemical fertilizer level.
Pengaruh Subletal Nanosuspensi Lantana camara Linnaeus dalam Menghambat Perkembangan dan Lolos Hidup Larva Croccidolomia pavonana Fabricius (Lepidoptera: Crambidae)
Authors: Melanie Melanie , Hermawan Wawan , Rustama Mia Miranti , Malini Desak Made , Husodo Teguh , Panatarani Camellia , Joni I Made 
Published: April 2023

Aplikasi insektisida sintetik pada tanaman kubis seringkali mendapatkan kendala, salah satunya karena insektisida tidak dapat merekat dengan baik pada permukaan daun kubis yang mengandung lapisan lilin. Penelitian ini dilakukan dengan tujuan untuk mendapatkan formulasi nanosuspensi bioinsektisida yang dapat digunakan untuk mengendalikan larva Crocidolomia pavonana pada tanaman kubis. Nanosuspensi Fraksi Etil Asetat (FEA) daun Lantana camara telah diketahui berpotensi sebagai antifidan terhadap larva C. pavonana. Formula nanosuspensi dengan rasio surfaktan (SOR 9, 11, 12, dan 14) di formulasikan dalam media air menggunakan metode emulsi sederhana energi rendah ditambah dengan interferensi ultrasonikasi. Uji bioassay dilakukan untuk menentukan kategori toksisitas dan bioaktivitas nanosuspensi pada konsentrasi subletal terhadap perkembangan larva hingga pupa C. pavonana. Formula nanosuspensi FEA L. camara dengan variasi SOR 11 (D= 76,6 nm; PI= 0,589; Z = -4,4 mV) diketahui terdispersi dalam media air yang terbaik diantara variasi komposisi formula lainnya. Hasil uji toksisitas menunjukkan bahwa efek subletal nanosuspensi (SOR 11) LC50 48 jam (2.948 ppm) dan LC50 72 jam (3.897 ppm) dikategorikan sebagai toksikan sedang, dan secara nyata menghambat perkembangan dan lolos hidup larva C. pavonana instar 3 menuju pre-pupa (P<0,05), dengan rata-rata waktu perkembangan terlama 6,5 hari (SOR 11), dan persentase lolos hidup terendah instar 4 menuju fase pupa pada perlakuan SOR 11 (13,33%). Pupa diketahui tidak mampu berkembang ke tahap imago pada semua variasi SOR, yang diindikasikan melalui cacat dan kematian pupa. Dengan demikian, toksisitas nanosuspensi FEA L. camara yang rendah menjadikannya formula yang efektif dan berpotensi utuk mencegah resistensi C. pavonana.
A Dark Shadow: The Intensification and Expansion of Lethal Injection Drug Secrecy
Authors: Sarat Austin , Dassin Theo , Orr Aidan 
Published: April 2023

Abstract
Over the last decade, many death penalty states in the United States have enacted secrecy laws shielding the identity of lethal injection drug suppliers and executioners. Death penalty defense lawyers, legislators, and scholars have examined the constitutionality and efficacy of these laws. However, little attention has been paid to the history of death penalty secrecy and its relationship to existing secrecy statutes. This article analyzes that history and relationship. It describes a surprising pattern of openness and transparency about the identities of executioners and others involved in America's capital punishment process. Current lethal injection secrecy laws break with that pattern and cast a virtually unprecedented shadow over the execution process. This article concludes by assessing the consequences of the recent intensification and expansion of execution secrecy.
Review of Sustainable Cryopreservation and Above-Freezing Storage Solutions of European Honey Bee Apis mellifera Drone Semen
Authors: Smilga-Spalvina Agnese , Spalvins Kriss , Veidenbergs Ivars 
Published: April 2023

Abstract
The European honey bee Apis mellifera is the main pollinator for most crops used for human consumption. However, a number of diseases, parasites, pesticides and other factors that generally result in the widely described colony collapse disorder weakens honey bee colonies. In order to maintain the existing honey bee germ lines and facilitate the creation of new disease-resistant lines, it is necessary to ensure consistent breeding work, which would also allow the long-term preservation of the unique germplasm lines. One of the most promising solutions for the preservation of honey bee germplasm is the storage of honey bee drone semen. In recent decades, there has been a renewed interest in the preservation of honey bee drone semen using both cryopreservation and above-freezing storage methods. This review summarizes the latest developments in novel sperm storage technologies and their assessment by sperm quality and queen fertility indicators. Additionally, this article analyses the advantages and disadvantages of the reviewed solutions and outlines directions in which additional research would be needed to develop effective, available and affordable drone semen storage solutions. To the best of the authors' knowledge this is the first review of cryopreservation and above-freezing storage solutions of European honey bee Apis mellifera drone semen in the scientific literature.