bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital Health Interventions for Adult Patients With Cancer Evaluated in Randomized Controlled Trials: Scoping Review
Authors: Lee Kyunghwa , Kim Sanghee , Kim Soo Hyun , Yoo Sung-Hee , Sung Ji Hyun , Oh Eui Geum , Kim Nawon , Lee Jiyeon 
Published: January 2023

Background
Digital care has become an essential component of health care. Interventions for patients with cancer need to be effective and safe, and digital health interventions must adhere to the same requirements.

Objective
The purpose of this study was to identify currently available digital health interventions developed and evaluated in randomized controlled trials (RCTs) targeting adult patients with cancer.

Methods
A scoping review using the JBI methodology was conducted. The participants were adult patients with cancer, and the concept was digital health interventions. The context was open, and sources were limited to RCT effectiveness studies. The PubMed, CINAHL, Embase, Cochrane Library, Research Information Sharing Service, and KoreaMed databases were searched. Data were extracted and analyzed to achieve summarized results about the participants, types, functions, and outcomes of digital health interventions.

Results
A total of 231 studies were reviewed. Digital health interventions were used mostly at home (187/231, 81%), and the web-based intervention was the most frequently used intervention modality (116/231, 50.2%). Interventions consisting of multiple functional components were most frequently identified (69/231, 29.9%), followed by those with the self-manage function (67/231, 29%). Web-based interventions targeting symptoms with the self-manage and multiple functions and web-based interventions to treat cognitive function and fear of cancer recurrence consistently achieved positive outcomes. More studies supported the positive effects of web-based interventions to inform decision-making and knowledge. The effectiveness of digital health interventions targeting anxiety, depression, distress, fatigue, health-related quality of life or quality of life, pain, physical activity, and sleep was subject to their type and function. A relatively small number of digital health interventions specifically targeted older adults (6/231, 2.6%) or patients with advanced or metastatic cancer (22/231, 9.5%).

Conclusions
This scoping review summarized digital health interventions developed and evaluated in RCTs involving adult patients with cancer. Systematic reviews of the identified digital interventions are strongly recommended to integrate digital health interventions into clinical practice. The identified gaps in digital health interventions for cancer care need to be reflected in future digital health research.
Understanding the Public’s Attitudes Toward COVID-19 Vaccines in Nottinghamshire, United Kingdom: Qualitative Social Media Analysis
Authors: Jones Leah Ffion , Bonfield Stefanie , Farrell Jade , Weston Dale 
Published: January 2023

Background
COVID-19 vaccines remain central to the UK government’s plan for tackling the COVID-19 pandemic. Average uptake of 3 doses in the United Kingdom stood at 66.7% as of March 2022; however, this rate varies across localities. Understanding the views of groups who have low vaccine uptake is crucial to guide efforts to improve vaccine uptake.

Objective
This study aims to understand the public’s attitudes toward COVID-19 vaccines in Nottinghamshire, United Kingdom.

Methods
A qualitative thematic analysis of social media posts from Nottinghamshire-based profiles and data sources was conducted. A manual search strategy was used to search the Nottingham Post website and local Facebook and Twitter accounts from September 2021 to October 2021. Only comments in the public domain and in English were included in the analysis.

Results
A total of 3508 comments from 1238 users on COVID-19 vaccine posts by 10 different local organizations were analyzed, and 6 overarching themes were identified: trust in the vaccines, often characterized by a lack of trust in vaccine information, information sources including the media, and the government; beliefs about safety including doubts about the speed of development and approval process, the severity of side effects, and belief that the ingredients are harmful; belief that the vaccines are not effective as people can still become infected and spread the virus and that the vaccines may increase transmission through shedding; belief that the vaccines are not necessary due to low perceived risk of death and severe outcomes and use of other protective measures such as natural immunity, ventilation, testing, face coverings, and self-isolation; individual rights and freedoms to be able to choose to be vaccinated or not without judgement or discrimination; and barriers to physical access.

Conclusions
The findings revealed a wide range of beliefs and attitudes toward COVID-19 vaccination. Implications for the vaccine program in Nottinghamshire include communication strategies delivered by trusted sources to address the gaps in knowledge identified while acknowledging some negatives such as side effects alongside emphasizing the benefits. These strategies should avoid perpetuating myths and avoid using scare tactics when addressing risk perceptions. Accessibility should also be considered with a review of current vaccination site locations, opening hours, and transport links. Additional research may benefit from using qualitative interviews or focus groups to further probe on the themes identified and explore the acceptability of the recommended interventions.
Edição 20 (4) outubro/dezembro 2022
Authors: Chizzotti Antonio , Almeida Maria Elizabeth Bianconcini de 
Published: January 2023

Ao considerar a educação e o currículo como território de formação e de experiência cidadã, a Revista e-Curriculum entende a vida permeada de tensões, de contestações e de lutas, e assume, como princípio epistemológico, a pedagogia crítica vinculada à educação transformadora e à emancipação humana. Os artigos ora publicados giram em torno da denúncia de interesses implícitos nas atuais políticas educacionais com os mecanismos de destruição perpetrados e de paradoxos reveladores de potências transformadoras que permitiram contornar, parcialmente, os problemas e agir segundo os princípios da educação democrática, da justiça e da equidade social. Nesta óptica, a presente edição compõe-se de 20 artigos, um deles de entrevista, aglutinados em torno da educação e do currículo e desdobrados em temáticas que convergem com a diversidade cultural, a contracolonização, a identidade de gênero, as políticas públicas, a formação e a prática pedagógica, a juventude, as tecnologias e seus metaversos, os algoritmos e as fake news veiculadas, a financeirização da educação, com ênfase em estudos sobre diferentes contextos e níveis de ensino.
Nossa Raiva como Dispositivo de Contracolonização dos Currículos
Authors: Meira Flávia Paola Félix , Oliveira Julvan Moreira de 
Published: January 2023

Este trabalho tem como objetivo dialogar com as histórias, os traumas e as alegrias que impulsionam o processo de pesquisa de mulheres negras e que figuram em seus trabalhos acadêmicos, cujo propósito era o de investigar como ocorreu a implementação das Diretrizes Curriculares Nacionais para a Educação das Relações Étnico-Raciais e para o Ensino de História e Cultura Afro-Brasileira e Africana (DCNERER) nos cursos de Pedagogia. A partir das perspectivas decolonial e pós-colonial, realizamos uma análise pormenorizada de dez produções. Identificamos como o racismo experimentado por essas mulheres, bem como alguns marcadores africanos, fizeram-se presentes em suas trajetórias, pavimentando um desejo de compreender como se consolida um currículo de formação de professores e como o tema das relações étnico-raciais permeia o território acadêmico.
Glycolysis Regulation to Maintain Blood Glucose Homeostasis
Authors: Salih Karzan Jalal , Sabir Dana Khdr , Abdoul Hayman Jalal 
Published: January 2023

Carbohydrates are the major source of energy for the living cells, they are the first cellular constituents that synthesized during photosynthesis from carbon dioxide and water by green plants through absorption of sun light. To be used as source of energy, carbohydrates compounds should undergo series of enzymatic metabolic stages in the cell. Beside the energy productions, catabolism of carbohydrates provides different intermediates molecules for the synthesis of biomolecules like fatty acids, amino acids, DNA, and RNA. Among the three main examples of monosaccharide (i.e: glucose, galactose, and mannose), glucose is considered as the central molecule in carbohydrate metabolism that all the major pathways of carbohydrate metabolism relate to it. Glucose is also an essential component of cellular metabolism in maintaining carbon homeostasis. Liver has shown to play a key role in monitoring and stabilizing blood glucose levels, therefore, it can be considered as glucostate monitor. In this article, we will review the major metabolic pathways of carbohydrate metabolism, their biochemical role in cellular energy production, and latest development in the understanding in these fields. Also, we discuss about the factors that participate in regulation of blood glucose concentration. We believe understand these process is essential for control scarbohydrate-related human disorders.
PENGEMBANGAN BAHAN AJAR WORDLESS PICTURE BOOK DIGITAL BERBASIS NILAI KARAKTER DALAM PEMBELAJARAN PENDIDIKAN PANCASILA DAN KEWARGANEGARAAN KELAS III SEKOLAH DASAR
Authors: Azzahra Alfina Firda , Nurhasanah Nina , Yarmi Gusti 
Published: January 2023

Abstract: Development of Digital Wordless Picture Book Teaching Materials Based on Character Values in Learning Pancasila and Citizenship Education for Class III Elementary Schools. This study aims to introduce and apply character values in everyday life. This type of research is Research and Development (Reseach and Development) using the Four D (4D) development model. The data analysis technique used in this research is quantitative descriptive statistics. The data in this study were obtained from expert validation of Civics learning materials of 90% very good, media expert validation 96.36% very good, linguistic expert validation 96% very good, and the results of development trials (one to one evaluation, small group evaluation and field test) 100% very good. The results of the development in this study were in the form of digital wordless picture book teaching materials based on character values in Pancasila and Citizenship Education (PPKn) Class III Elementary School learning.Keyword: Development, Wordless Picture Book, Pancasila and Citizenship Education (PPKn) Abstrak : Pengembangan Bahan Ajar Wordless Picture Book Digital Berbasis Nilai Karakter dalam Pembelajaran Pendidikan Pancasila dan Kewarganegaraan Kelas III Sekolah Dasar. Penelitian ini bertujuan untuk mengenalkan dan menerapkan nilai karakter dalam kehidupan sehari-hari. Jenis Penelitian ini adalah Penelitian dan Pengembangan (Reseach dan Development) dengan menggunakan model pengembangan Four D (4D). Teknik analisis data yang digunakan dalam peneilitain ini adalah statistik deskriptig kuantitatif. Data dalam penelitian ini diperoleh dari validasi ahli materi pembelajaran PPKn sebesar 90% sangat baik, validasi ahli media 96,36% sangat baik, validasi ahli bahasa 96% sangat baik, dan hasil uji coba pengembangan (one to one evaluation, small group evaluation dan field test) 100% sangat baik. Hasil pengembangan pada penelitian ini berupa produk bahan ajar wordless picture book digital berbasis nilai karakter pada pembelajaran Pendidikan Pancasila dan Kewarganegaraan (PPKn) Kelas III Sekolah Dasar.Kata Kunci: Pengembangan, Wordless Picture Book, Pendidikan Pancasila dan Kewarganegaraan (PPKn)
Computed tomographic lymphangiography following percutaneous intrahepatic injection of iopamidol in cats
Authors: Johnson Eric G. , Mayhew Philipp D. , Runge Jeffrey J. 
Published: January 2023

Abstract

OBJECTIVE
To determine if computed tomographic lymphangiography (CTL) after ultrasound-guided percutaneous injection of intrahepatic iopamidol (Isovue 370) in healthy cats would safely and effectively lead to opacification of the hepatic lymphatics, cisterna chyli, and thoracic ducts (TDs).

STUDY DESIGN
A prospective pilot study design with randomization of the sides of the liver injected.

SAMPLE POPULATION
6 purpose-bred cats.

PROCEDURES
Cats were anesthetized and based on random assignment, and the left or right liver was injected with iodinated contrast material. CTL images were taken at 5, 10, and 15 minutes postinjection to determine the quality of opacification of the cisterna chyli and TDs.

RESULTS
Eleven hepatic injections from 6 cats were available for review. One CT file was corrupted and unusable. Seven out of 11 hepatic contrast injections yielded a diagnostic study. Five out of 11 were graded as excellent, 0/11 were graded as good, and 2/11 were graded as fair. Opacification of the cisterna chyli and TDs was absent in 4/11 studies. Three out of 6 cats had mild to moderate increases in hepatocellular enzymes when assayed 3 months postprocedure. The hepatic lymphatics, cisterna chyli, and TDs were opacified in all studies deemed diagnostic.

CLINICAL RELEVANCE
Intrahepatic contrast injection offers a novel portal for thoracic duct lymphangiography that documents the hepatic contribution to the mesenteric lymphatics, cisterna chyli, and thoracic duct. The procedure may be helpful in the preoperative diagnostic evaluation of cats with chylothorax.
Evaluation of bacterial uptake, antibacterial efficacy against Escherichia coli, and cytotoxic effects of moxifloxacin-loaded solid lipid nanoparticles
Authors: Kiymaci Merve Eylul , Topal Gizem Ruya , Esim Ozgur , Bacanli Merve , Ozkan Cansel Kose , Erdem Onur , Savaser Ayhan , Ozkan Yalcin 
Published: January 2023

Abstract
Moxifloxacin (MOX) is an important antibiotic commonly used in the treatment of recurrent Escherichia coli (E. coli) infections. The aim of this study was to investigate its antibacterial efficiency when used with solid lipid nanoparticles (SNLs) and nanostructured lipid carriers (NLCs) as delivery vehicles. For this purpose we designed two SLNs (SLN1 and SLN2) and two NLCs (NLC1 and NLC2) of different characteristics (particle size, size distribution, zeta potential, and encapsulation efficiency) and loaded them with MOX to determine its release, antibacterial activity against E. coli, and their cytotoxicity to the RAW 264.7 monocyte/macrophage-like cell line in vitro. With bacterial uptake of 57.29 %, SLN1 turned out to be significantly more effective than MOX given as standard solution, whereas SLN2, NLC1, and NLC2 formulations with respective bacterial uptakes of 50.74 %, 39.26 %, and 32.79 %, showed similar activity to standard MOX. Cytotoxicity testing did not reveal significant toxicity of nanoparticles, whether MOX-free or MOX-loaded, against RAW 264.7 cells. Our findings may show the way for a development of effective lipid carriers that reduce side effects and increase antibacterial treatment efficacy in view of the growing antibiotic resistance.
Repeated measurements of depression and outcomes in patients receiving hemodialysis†
Authors: Zhang Lu , Zhang Su-Mei , Shi Sheng-Yan , Quan Hai-Ying , Yang Xiu 
Published: January 2023

Abstract

Objective: Depression appears to be common among the patients with end-stage renal disease (ESRD). Therefore, how to comprehensively analyze the changes in depression and its impact on patient outcomes is an important research direction. The objectives of this study were to assess changes in depression and whether depression can be used to predict outcomes in patients receiving hemodialysis.

Methods: In a longitudinal study, 317 patients receiving hemodialysis from two hospitals were investigated. Depression was assessed using the Hamilton Depression Scale (HAMDS) at baseline. Outcomes data (survival and mortality) were collected from baseline to the end of follow-up 2 years later. Mortality was assessed using Cox proportional hazards analysis.

Results: The HAMDS score and percentage of high scores increased at three time points. Moreover, the changes were statistically significant. Surviving patients had significantly lower HAMDS scores. Through multivariate Cox regression analysis, age and depression can be used to predict mortality (P < 0.05), and the relative risks (RRs) were 1.032 and 1.069, respectively.

Conclusions: Depression in patients receiving hemodialysis is worse. Moreover, baseline depression is an independent predictor of outcomes. Patients receiving hemodialysis should be focused on improving their psychological complications. A systematic and individual psychological health promotion plan must also be incorporated into the health education plan for patients receiving hemodialysis.
Depressive symptoms, social support, cognitive function, and stigma: predictors of resilience in caregivers of children with intellectual disabilities
Authors: Tejakum Wattana , Tankumpuan Thitipong , Suksatan Wanich , Saboonma Jirapan , Phetrasuwan Supapak , Rodney Tamar 
Published: January 2023

Abstract

Objective: Family plays an important role in taking care of children with intellectual disabilities (IDs). Resilience supports coping strategies for caregivers with their children caring. However, factors influencing the resilience of caregivers with ID in Thailand are yet to be identified. Therefore, the aim of this study was to identify the predictors of resilience in caregivers of children with moderate to severe ID.

Methods: A cross-sectional study was implemented in caregivers of children with ID aged 18 years and older who had children diagnosed with ID aged 6–18 years and classified as moderate to severe ID. Descriptive statistic and multiple linear regression were used for data analysis.

Results: The study sample consisted of 85 caregivers who took care of their children older than 5 years (95.30%). Depression, social support, cognitive function, and stigma could predict the resilience (F [4, 80] = 26.79, P < 0.001) and explain the variability of resilience by 57.3%.

Conclusions: Caregivers have to take care of their children for a long period, which could develop a burden to the caregivers. The resilience and influencing factors should be monitored and managed by developing a campaign to promote caregivers’ health and well-being.
Experiences of Chinese nurses studying for master’s degree in the UK: a qualitative study†
Authors: Ma Juan-Juan , Zhou Jie , Li Ting-Jun , Wang Li-Li , Tian Xiao-Fei 
Published: January 2023

Abstract

Objective: To explore experiences of Chinese nurses who study for Master of Science in Professional Practice (health care) in the United Kingdom.

Methods: A qualitative approach was applied, consisting of semi-structured telephone interviews (n = 8). The Colaizzi seven-step framework analysis method was used to extract themes.

Results: The themes that emerged are as follows: (1) gains from studying overseas, (2) difficulties during studying, and (3) impacts of learning experience on work. The gains for nurses studying overseas include the improvement of scientific research capabilities, reconstruction of critical thinking, and development of reflection ability. Difficulties while studying mainly include language barrier, strict assessment, and boring life.

Conclusions: The education of nursing postgraduate attaches importance to the cultivation of thinking. Nurses are very interested in nursing research including qualitative and quantitative methods. Nurses encountered language barriers in their study and life even though they knew a certain level of English.
Perioperative nursing of a newborn with Beckwith-Wiedemann syndrome
Authors: Zhu Qian , Wang Yue , Hou Jie-Yi , Wang Si-Yu 
Published: January 2023

Abstract

Objective: To explore the perioperative nursing of a newborn with Beckwith-Wiedemann syndrome.

Methods: We observed the blood glucose of the child and prevent infection of omphalocele before transportation and before the operation; after the operation, we performed airway nursing, blood glucose monitoring, urination observation, and tumor marker monitoring; finally, at the time of discharge from the hospital, we provided health education.

Results: After a series of perioperative nursing measures, the child was discharged smoothly from hospital 34 d after operation.

Conclusions: Beckwith-Wiedemann syndrome is a rare congenital malformation. Timely and accurate observation and evaluation of the child during perioperative period and targeted nursing measures can effectively reduce or avoid the occurrence of postoperative complications.
Energy Performance Aspects of Non-Residential Buildings in Latvia
Authors: Kundziņa A. , Geipele I. , Lapuke S. , Auders M. 
Published: January 2023

Abstract
Increase of energy efficiency is Latvia’s national priority and policy instrument that allows reducing consumption of energy and costs, increasing the safety level of energy supply and reducing dependence on import. One of the trends for reducing energy consumption is to increase energy performance of buildings. In compliance with the EU and Latvian political statements, it is required to promote renovation of residential and non-residential buildings.
Studies regarding energy performance aspects in the sector of non-residential buildings in Latvia are comparatively rare; however, non-residential buildings form a considerable part of the building stock, and the increase of their energy performance can bring a significant contribution in achieving the national targets.
The research analyses the sector of non-residential buildings, their characteristic statistical data, energy consumption and requirements of energy performance standards. To characterise this sector more comprehensively, information on energy performance certificates of buildings issued during the period from 2016 to 2021 has been evaluated, allowing to make general conclusions on the energy performance level of different non-residential buildings and provide proposals for trends to increase their energy efficiency.
Determining The Effect of Load on Synchronous Generator With Spark-Ignition Engine Energy Efficiency
Authors: Zaichenko S. , Dychko A. , Ercetin U. , Opryshko V. , Kleshchov A. 
Published: January 2023

Abstract
The paper presents a new approach to energy indicator determination, such as specific fuel consumption and energy efficiency of the power plant. The essence of the new method is to determine the instantaneous power of the installation with subsequent data processing. The use of this method allows establishing the dependence of specific energy indicators on the generating unit load levels. The established distribution allows defining optimum parameters of experimental setup and consumption at various loading levels. The highest specific energy consumption of fuel is observed (1189–1297 g /(kW·h) and 962–1147 g / / kW·h)) at the lowest and the highest load for different fuels. Experimental data show that fuel without ethanol impurities can generate more electricity, which should be used at higher demand.