bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prostate cancer cell-platelet bidirectional signaling promotes calcium mobilization, invasion and apoptotic resistance via distinct receptor-ligand pairs
Authors: Garofano Kaitlin , Rashid Kameron , Smith Michael , Brantner Christine , Suwunnakorn Sumanun , Diemert David , Gordon Olivia , Horvath Anelia , Khan Sikandar , Popratiloff Anastas , Rhim Johng , Sidahmed Alfateh , Maggirwar Sanjay B. , O’Brien Travis J. , Perera Minoli A. , Lee Norman H. 
Published: February 2023

AbstractPlatelets play a crucial role in cancer and thrombosis. However, the receptor-ligand repertoire mediating prostate cancer (PCa) cell-platelet interactions and ensuing consequences have not been fully elucidated. Microvilli emanating from the plasma membrane of PCa cell lines (RC77 T/E, MDA PCa 2b) directly contacted individual platelets and platelet aggregates. PCa cell-platelet interactions were associated with calcium mobilization in platelets, and translocation of P-selectin and integrin αIIbβ3 onto the platelet surface. PCa cell-platelet interactions reciprocally promoted PCa cell invasion and apoptotic resistance, and these events were insensitive to androgen receptor blockade by bicalutamide. PCa cells were exceedingly sensitive to activation by platelets in vitro, occurring at a PCa cell:platelet coculture ratio as low as 1:10 (whereas PCa patient blood contains 1:2,000,000 per ml). Conditioned medium from cocultures stimulated PCa cell invasion but not apoptotic resistance nor platelet aggregation. Candidate transmembrane signaling proteins responsible for PCa cell-platelet oncogenic events were identified by RNA-Seq and broadly divided into 4 major categories: (1) integrin-ligand, (2) EPH receptor-ephrin, (3) immune checkpoint receptor-ligand, and (4) miscellaneous receptor-ligand interactions. Based on antibody neutralization and small molecule inhibitor assays, PCa cell-stimulated calcium mobilization in platelets was found to be mediated by a fibronectin1 (FN1)-αIIbβ3 signaling axis. Platelet-stimulated PCa cell invasion was facilitated by a CD55-adhesion G protein coupled receptor E5 (ADGRE5) axis, with contribution from platelet cytokines CCL3L1 and IL32. Platelet-stimulated PCa cell apoptotic resistance relied on ephrin-EPH receptor and lysophosphatidic acid (LPA)-LPA receptor (LPAR) signaling. Of participating signaling partners, FN1 and LPAR3 overexpression was observed in PCa specimens compared to normal prostate, while high expression of CCR1 (CCL3L1 receptor), EPHA1 and LPAR5 in PCa was associated with poor patient survival. These findings emphasize that non-overlapping receptor-ligand pairs participate in oncogenesis and thrombosis, highlighting the complexity of any contemplated clinical intervention strategy.
Improving the efficiency of crossbred Pradu Hang Dam chicken production for meat consumption using cold plasma technology on eggs
Authors: Sakulthai Apichaya , Sawangrat Choncharoen , Pichpol Duangporn , Kongkapan Jutamart , Srikanchai Tiranun , Charoensook Rangsun , Sojithamporn Phanumas , Boonyawan Dheerawan 
Published: February 2023

AbstractThe Pradu Hang Dam chicken, a Thai Native Chicken (TNCs) breed, plays an important role in many regions of Thailand because of its chewiness. However, there are some challenges with Thai Native Chicken, such as low production and slow growth rates. Therefore, this research investigates the efficiency of cold plasma technology in enhancing the production and growth rates of TNCs. First, this paper presents the embryonic development and hatch of fertile (HoF) values of treated fertilized eggs. Chicken performance indices, such as feed intake, average daily gain (ADG), feed conversion ratio (FCR), and serum growth hormone measurement, were calculated to assess chicken development. Furthermore, the potential of cost reduction was evaluated by calculating return over feed cost (ROFC). Finally, the quality aspects of chicken breast meat, including color, pH value, weight loss, cooking loss, shear force, and texture profile analysis, were investigated to evaluate cold plasma technology's impact on chicken meat. The results demonstrated that the production rate of male Pradu Hang Dam chickens (53.20%) was higher than females (46.80%). Moreover, cold plasma technology did not significantly affect chicken meat quality. According to the average return over feed cost calculation, the livestock industry could reduce feeding costs by approximately 17.42% in male chickens. Therefore, cold plasma technology is beneficial to the poultry industry to improve production and growth rates and reduce costs while being safe and environmentally friendly.
Preclinical dental students self-assessment of an improved operative dentistry virtual reality simulator with haptic feedback
Authors: Rodrigues Pedro , Nicolau Francisco , Norte Martim , Zorzal Ezequiel , Botelho João , Machado Vanessa , Proença Luís , Alves Ricardo , Zagalo Carlos , Lopes Daniel Simões , Mendes José João 
Published: February 2023

AbstractTo test and evaluate the second installment of DENTIFY, a virtual reality haptic simulator for Operative Dentistry (OD), on preclinical dental students, by focusing on user performance and self-assessment. Twenty voluntary unpaid preclinical dental students, with different background experience, were enrolled for this study. After the completion of an informed consent, a demographic questionnaire, and being introduced to the prototype (on the first testing session), three testing sessions followed (S1, S2, S3). Each session involved the following steps: (I) free experimentation; (II) task execution; S3 also included (III) completion of questionnaires associated with the experiment (total of 8 Self-Assessment Questions (SAQ)); and (IV) guided interview. As expected, drill time decreased steadily for all tasks when increasing prototype use, verified by RM ANOVA. Regarding performance metrics (Comparisons by Student’s t-test and ANOVA) recorded at S3, in overall, a higher performance was verified for participants with the following characteristics: female, non-gamer, no previous VR experience and with over 2 semesters of previous experience of working on phantom models. The correlation between the participants’ performance (drill time), for the four tasks, and user self-assessment evaluation, verified by Spearman’s rho analysis, allowed to conclude that a higher performance was observed in students who responded that DENTIFY improved their self perception of manual force applied. Regarding the questionnaires, Spearman’s rho analysis showed a positive correlation between the improvement DENTIFY inputs on conventional teaching sensed by students, also enhancing their interest in learning OD, their desire to have more simulator hours and the improvement sensed on manual dexterity. All participating students adhered well to the DENTIFY experimentation. DENTIFY allows for student self-assessment and contributes to improving student performance. Simulators with VR and haptic pens for teaching in OD should be designed as a consistent and gradual teaching strategy, allowing multiplicity of simulated scenarios, bimanual manipulation, and the possibility of real-time feedback to allow for the student’s immediate self-assessment. Additionally, they should create performance reports per student to ensure self-perception/criticism of their evolution over longer periods of learning time.
Baseline characteristics in the Israel refraction, environment, and devices (iREAD) study
Authors: Shneor Einat , Ostrin Lisa A. , Doron Ravid , Benoit Julia S. , Levine Jonathan , Davidson Kevin , Gordon-Shaag Ariela 
Published: February 2023

AbstractThe purpose of this study is to present baseline data from a longitudinal study assessing behavioral factors in three groups of boys in Israel with varying myopia prevalence. Ultra-Orthodox (N = 57), religious (N = 67), and secular (N = 44) Jewish boys (age 8.6 ± 1.4 years) underwent cycloplegic autorefraction and axial-length measurement. Time-outdoors and physical-activity were assessed objectively using an Actiwatch. Ocular history, educational factors, and near-work were assessed with a questionnaire. Group effects were tested and mixed effects logistic and linear regression were used to evaluate behaviors and their relationship to myopia. The prevalence of myopia (≤ − 0.50D) varied by group (ultra-Orthodox: 46%, religious: 25%, secular: 20%, P < 0.021). Refraction was more myopic in the ultra-Orthodox group (P = 0.001). Ultra-Orthodox boys learned to read at a younger age (P < 0.001), spent more hours in school (P < 0.001), spent less time using electronic devices (P < 0.001), and on weekdays, spent less time outdoors (P = 0.02). Increased hours in school (OR 1.70) and near-work (OR 1.22), increased the odds of myopia. Being ultra-Orthodox (P < 0.05) and increased near-work (P = 0.007) were associated with a more negative refraction. Several factors were associated with the prevalence and degree of myopia in young boys in Israel, including being ultra-Orthodox, learning to read at a younger age, and spending more hours in school.
Rapid shift in greenhouse forcing of emerging arctic peatlands
Authors: Christensen Torben R. , Scheller Johan , Scheel Maria , Rudd Daniel Alexander , Jackowicz-Korczynski Marcin , Mastepanov Mikhail , López-Blanco Efrén 
Published: February 2023

AbstractIn this study, we hypothesised that the actual development stage (i.e., current age of the ecosystem) is a determining factor for the magnitude of methane production and emissions in young, northern high-latitude peatlands. We demonstrate that the earliest development of peat soil imposes a sink-to-source shift in the greenhouse warming potential of emerging peatlands in response to climate change that holds feedback mechanisms of importance for short-term (< 100 years) climate warming.
Modulation of AMPK/ TET2/ 5-hmC axis in response to metabolic alterations as a novel pathway for obesity-related colorectal cancer development
Authors: Kon Takashi , Sasaki Yu , Abe Yasuhiko , Onozato Yusuke , Yagi Makoto , Mizumoto Naoko , Sakai Takayuki , Umehara Matsuki , Ito Minami , Nakamura Shuhei , Goto Hiroki , Ueno Yoshiyuki 
Published: February 2023

AbstractObesity is a major risk factor for colorectal cancer (CRC). Sustained hyperglycemia destabilizes tumor suppressor ten-eleven translocation (TET) 2, which is a substrate of AMPK, thereby dysregulating 5-hydroxymethylcytosine (5-hmC). However, the role played by this novel pathway in the development of obesity-related CRC is unclear. In this study, we aimed to evaluate the expression levels of TET2 and 5-hmC in obesity-related CRC and the effects of TET2 expression on the proliferation of CRC cells. To this end, surgically resected CRC samples from seven obese patients (Ob-CRC) and seven non-obese patients (nOb-CRC) were analyzed, and expression levels of the TET family and 5-hmC were compared between the groups. A decrease was observed in TET2 mRNA levels and 5-hmC levels in Ob-CRC compared to that in nOb-CRC. Furthermore, we used CRC cell lines to investigate the relationship between insulin, proliferation, and TET expression and AMPK. In cell lines, glucose and insulin treatments suppressed the expression of TET2 and increased cell proliferation. Downregulation of TET2 using siRNA also induced cell proliferation. An AMPK activator inhibited insulin- or glucose-stimulated cell proliferation and restored TET2 expression. We propose the AMPK-TET2-5-hmC axis as a novel pathway and potential therapeutic target in obesity-related CRC development.
Short‐term and long‐term memory self‐attention network for segmentation of tumours in 3D medical images
Authors: Wen Mingwei , Zhou Quan , Tao Bo , Shcherbakov Pavel , Xu Yang , Zhang Xuming 
Published: February 2023

AbstractTumour segmentation in medical images (especially 3D tumour segmentation) is highly challenging due to the possible similarity between tumours and adjacent tissues, occurrence of multiple tumours and variable tumour shapes and sizes. The popular deep learning‐based segmentation algorithms generally rely on the convolutional neural network (CNN) and Transformer. The former cannot extract the global image features effectively while the latter lacks the inductive bias and involves the complicated computation for 3D volume data. The existing hybrid CNN‐Transformer network can only provide the limited performance improvement or even poorer segmentation performance than the pure CNN. To address these issues, a short‐term and long‐term memory self‐attention network is proposed. Firstly, a distinctive self‐attention block uses the Transformer to explore the correlation among the region features at different levels extracted by the CNN. Then, the memory structure filters and combines the above information to exclude the similar regions and detect the multiple tumours. Finally, the multi‐layer reconstruction blocks will predict the tumour boundaries. Experimental results demonstrate that our method outperforms other methods in terms of subjective visual and quantitative evaluation. Compared with the most competitive method, the proposed method provides Dice (82.4% vs. 76.6%) and Hausdorff distance 95% (HD95) (10.66 vs. 11.54 mm) on the KiTS19 as well as Dice (80.2% vs. 78.4%) and HD95 (9.632 vs. 12.17 mm) on the LiTS.
TANet: Transformer‐based asymmetric network for RGB‐D salient object detection
Authors: Liu Chang , Yang Gang , Wang Shuo , Wang Hangxu , Zhang Yunhua , Wang Yutao 
Published: February 2023

AbstractExisting RGB‐D salient object detection methods mainly rely on a symmetric two‐stream Convolutional Neural Network (CNN)‐based network to extract RGB and depth channel features separately. However, there are two problems with the symmetric conventional network structure: first, the ability of CNN in learning global contexts is limited; second, the symmetric two‐stream structure ignores the inherent differences between modalities. In this study, a Transformer‐based asymmetric network is proposed to tackle the issues mentioned above. The authors employ the powerful feature extraction capability of Transformer to extract global semantic information from RGB data and design a lightweight CNN backbone to extract spatial structure information from depth data without pre‐training. The asymmetric hybrid encoder effectively reduces the number of parameters in the model while increasing speed without sacrificing performance. Then, a cross‐modal feature fusion module which enhances and fuses RGB and depth features with each other is designed. Finally, the authors add edge prediction as an auxiliary task and propose an edge enhancement module to generate sharper contours. Extensive experiments demonstrate that our method achieves superior performance over 14 state‐of‐the‐art RGB‐D methods on six public datasets. The code of the authors will be released at https://github.com/lc012463/TANet.
Multi‐agent voltage balancing in modular motor drives with series‐connected power electronic converters
Authors: Verkroost Lynn , Vande Ghinste Alexander , Vanthuyne Karel , Van Damme Jordi , De Belie Frederik , Sergeant Peter , Vansompel Hendrik 
Published: February 2023

AbstractModular motor drives can be considered as multi‐agent systems, in which the agents can work together to reach a common goal. One agent in such a modular motor drive consists of only a subset of the machine phases and power electronic converter modules, and is equipped with a dedicated controller. When the dc‐links of the different agents are connected in series to a single voltage source, giving rise to a so‐called stacked polyphase bridges converter, the power electronic converter components can have low voltage ratings. However, a voltage balancing controller must ensure that the total dc‐link voltage is distributed evenly among the agents when working in motoring mode. The goal of this research is to propose a multi‐agent voltage balancing algorithm based on dynamic average consensus, which depends solely on local computations, local measurements, and neighbour‐to‐neighbour communication. The scalability and reliability of the modular hardware are hence extended towards the control. Simulations and experimental results on a 4 kW modular axial‐flux PMSM demonstrate the feasibility of the concept.
Magnetic reconnection plasmoid model for Sagittarius A* flares
Authors: Aimar N. , Dmytriiev A. , Vincent F. H. , El Mellah I. , Paumard T. , Perrin G. , Zech A. 
Published: February 2023

Context. Sagittarius A*, the supermassive black hole at the center of our Galaxy, exhibits episodic near-infrared flares. The recent monitoring of three such events with the GRAVITY instrument has shown that some flares are associated with orbital motions in the close environment of the black hole. The GRAVITY data analysis indicates a super-Keplerian azimuthal velocity, while (sub-) Keplerian velocity is expected for the hot flow surrounding the black hole.
Aims. We develop a semi-analytic model of the Sagittarius A* flares based on an ejected large plasmoid, inspired by recent particle-in-cell global simulations of black hole magnetospheres. We model the infrared astrometric and photometric signatures associated with this model.
Methods. We considered a spherical macroscopic hot plasma region that we call a large plasmoid. This structure was ejected along a conical orbit in the vicinity of the black hole. This plasmoid was assumed to be formed by successive mergers of smaller plasmoids produced through magnetic reconnection that we did not model. Nonthermal electrons were injected into the plasmoid. We computed the evolution of the electron-distribution function under the influence of synchrotron cooling. We solved the radiative transfer problem associated with this scenario and transported the radiation along null geodesics of the Schwarzschild space time. We also took the quiescent radiation of the accretion flow into account, on top of which the flare evolves.
Results. For the first time, we successfully account for the astrometric and flux variations of the GRAVITY data with a flare model that incorporates an explicit modeling of the emission mechanism. The prediction of our model and recent data agree well. In particular, the azimuthal velocity of the plasmoid is set by the magnetic field line to which it belongs, which is anchored in the inner parts of the accretion flow, hence the super-Keplerian motion. The astrometric track is also shifted with respect to the center of mass due to the quiescent radiation, in agreement with the difference measured with the GRAVITY data.
Conclusions. These results support the hypothesis that magnetic reconnection in a black hole magnetosphere is a viable model for the infrared flares of Sagittarius A*.
Geomembranes for Canal Lining – Rehabilitation of a Hydropower Channel
Authors: Tarnowski Catrin 
Published: February 2023

Over a number of decades the geosynthetics industry has developed a wide range of materials that are used for multiple canal applications to reduce seepage. Their performance compared with traditional solutions using mineral layers has been demonstrated. The choice of the appropriate material is related to different scenarios:

• New canal lining or refurbishment
• Surface conditions (roughness)
• Covered or uncovered application
• Weather conditions during installation and operation
• Cost of installation/system
White surfaced geomembranes manufactured with LLDPE were chosen for the refurbishment of the “Schütt” hydropower channel in Austria taking the above into account.
Comparison of Capsular Tension Ring Implantation before vs. after Toric
Intraocular Lens for Rotational Stability
Authors: Cetinkaya Servet , Ucar Fikret 
Published: February 2023

Abstract
Purpose To compare the effect of implanting the capsular tension ring (CTR) before
or after a toric intraocular lens (IOL) on rotational stability in patients with cataract
and astigmatism.
Methods This is a randomized retrospective study. Patients who underwent
phacoemulsification combined with toric IOL implantation due to cataract and astigmatism
between February 2018 and October 2019 were enrolled in the study. Group 1 consisted of 53
eyes of 53 patients in whom the CTR was placed into the capsular bag after the
implantation of the toric IOL. On the other hand, group 2 consisted of 55 eyes of 55
patients in whom the CTR was placed into the capsular bag before implantation of the toric
IOL. The two groups were compared in terms of preoperative and postoperative astigmatism,
uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), and postoperative
IOL rotation degree.
Results There were no significant differences between the two groups related to
age and sex (p > 0.05) or the mean preoperative spherical value, UCVA, BCVA, and
corneal astigmatism (p > 0.05). Although the mean postoperative residual astigmatism of
the first group (− 0.29 ± 0.26) was lower than that of the second (− 0.43 ± 0.31), the
difference was not statistically significant (p = 0.16). The mean degree of rotation was
0.75 ± 2.66° in group 1 and 2.90 ± 6.57° in group 2, which was found to be statistically
significant (p = 0.02).
Conclusion The implantation of CTR after a toric IOL provides further rotational
stability and more effective astigmatic correction.
Post-Load Insulin Secretion Patterns are Associated with Glycemic
Status and Diabetic Complications in Patients with Type 2 Diabetes
Mellitus
Authors: Jiang Jiajia , Li Yuhao , Li Feng , He Yan , Song Lijuan , Wang Kun , You Wenjun , Xia Zhang , Zuo Yingting , Su Xin , Zhai Qi , Zhang Yibo , Gaisano Herbert , Zheng Deqiang 
Published: February 2023

Abstract
Background To examine whether the different patterns of post-load insulin
secretion can identify the heterogeneity of type 2 diabetes mellitus (T2DM).
Methods Six hundred twenty-five inpatients with T2DM at Jining No. 1
People’s Hospital were recruited from January 2019 to October 2021. The
140 g steamed bread meal test (SBMT) was conducted on patients with
T2DM, and glucose, insulin, and C-peptide levels were recorded at 0, 60, 120,
and 180 min. To avoid the effect of exogenous insulin, patients were
categorized into three different classes by latent class trajectory analysis
based on the post-load secretion patterns of C-peptide. The difference in short-
and long-term glycemic status and prevalence of complications distributed among
the three classes were compared by multiple linear regression and multiple
logistic regression, respectively.
Results There were significant differences in long-term glycemic status
(e. g., HbA1c) and short-term glycemic status (e. g., mean blood
glucose, time in range) among the three classes. The difference in short-term
glycemic status was similar in terms of the whole day, daytime, and nighttime.
The prevalence of severe diabetic retinopathy and atherosclerosis showed a
decreasing trend among the three classes.
Conclusions The post-load insulin secretion patterns could well identify
the heterogeneity of patients with T2DM in short- and long-term glycemic status
and prevalence of complications, providing recommendations for the timely
adjustment in treatment regimes of patients with T2DM and promotion of
personalized treatment.