bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanochemical Activation of Ternary Auxiliary Cementitious Materials Based on Iron Tailings
Authors: Zhang Nian Yan , Li Qi , Zhao Jian , An Ming 
Published: July 2023

Abstract
Due to the large amount of carbon dioxide emitted by cement, more and more people are concerned about the sustainability and decarbonization of the cement industry. At present, the most common practice is to incorporate solid waste into concrete to achieve urban sustainability. Iron Ore Tails (IOTs) can serve as SCMs using various activation methods, but comprehensive research is lacking on the calcium phase solid waste of the ternary SCMs system (IOT, steel slag, and desulfurization ash) based on IOTs. In this paper, the following parameters are selected when studying the factors affecting the strength of ISD system. These parameters are water-binder ratio, grinding time of iron tailings, admixture ratio and chemical activator content. The study also analyzes the impact of IOT-based ternary SCMs on concrete performance, and the microstructure of concrete is evaluated using XRD, DTA-TG, mercury intrusion method, and SEM.
Permeability Evolution and Damage Characterization of Sandstone under Various Confining Pressures and Seepage Pressure Gradients
Authors: Lin Zhinan , Long Haifeng , Wang Jiaquan , Zhang Qiang 
Published: July 2023

Abstract
In the realm of deep hydraulic engineering, diversion caverns often confront significant challenges due to high in-situ stress and high seepage pressure gradient. These conditions result in intricate mechanical behavior and permeability characteristics within the surrounding rock. In light of this, the present study aims to investigate the relationship between damage evolution and permeability characteristics of sandstone prior to failure under hydromechanical coupling conditions through a series of hydromechanical coupling tests. The results of these tests demonstrate that the strength and deformation resistance of sandstone exhibit variations corresponding to changes in the seepage pressure gradient. Moreover, an increase in seepage pressure gradient leads to a shift in the failure patterns of sandstone from low-inclination shear failure to steep-angle shear failure. Throughout the failure process of sandstone, the permeability curve initially decreases, followed by a rapid increase before ultimately stabilizing. Notably, the peak value of the permeability curve lags behind that of the stress-strain curve. Furthermore, when the seepage pressure gradient initially rises and then drops, the permeability of sandstone undergoes an irreversible change in the opposite direction, failing to return to its initial value. Based on these observations, a statistical damage model is proposed for rocks, accounting for hydromechanical coupling. Remarkably, the theoretical values derived from this model align well with experimental results. This model, grounded in the laws governing permeability evolution and damage properties of sandstone prior to failure, offers valuable guidance for monitoring and controlling rock stability in diversion caverns subjected to hydromechanical coupling actions.
Comparing the Efficacy of Sensory Motor Rhythm and Alpha-Theta Increase Protocol of Neurofeedback Training for Generalized Anxiety Disorder
Authors: Lotfinia Shahab , Shahkaram Homa , Yaseri Aram , KianiMoghadam AmirSam , Arani Abbas Masjedi 
Published: July 2023

Abstract
Neurofeedback training is one of the alternative therapies for Generalized anxiety disorder. Although research suggests its effective therapy, there is a lack of studies for comparing different protocols. So, this study aimed at comparing sensory motor rhythm and alpha-theta increase protocol of neurofeedback. In this research, a two-arm randomized trial was conducted to compare two different protocols of neurofeedback. A total of 40 individuals diagnosed with generalized anxiety disorder were assigned to either group which received 15 sessions of alpha-theta increase on Pz and group two received 15 sessions of sensory motor rhythm increase on Cz. Pretest and post-test measurements were taken using Beck Anxiety Inventory, State-Trait Spielberg, and Perceived Stress Scale, and finally data were analyzed using IBM SPSS v24 software. The results of the Wilcoxon test shows both protocols significantly reduced anxiety symptoms, but the alpha-theta protocol was more effective in reducing state anxiety and the sensory motor rhythm protocol was more effective in reducing Beck Anxiety Inventory and Perceived Stress Scale. According to the research, both protocols are effective in reducing anxiety. However, they each have their own advantages in reducing specific anxiety symptoms.
Effects of Various Land Use Land Cover (LULC) Data on Hydrological Model Performances
Authors: Peker İsmail Bilal , Cüceloğlu Gökhan , Gülbaz Sezar , Serengil Yusuf 
Published: July 2023

Abstract
Land cover is a significant input in hydrological modeling, and its features may affect model performances. To evaluate its impact on evapotranspiration, surface runoff, and water yield, we tested six open-source LULC data products (GLCC, GLC 2000, GlobCover 2005, GLCNMO V1, CLC 1990, and PELCOM) in the Emet-Orhaneli Basin located in western Anatolia. The Soil and Water Assessment Tool (SWAT) was employed to assess hydrological responses. Following the model calibration with observed streamflow data, the changes in outputs over the 1980–2012 period were compared temporally and spatially. The results revealed that temporal and spatial changes in evapotranspiration and water yield were slight, whereas surface runoff varied more significantly in monthly and interannual intervals. The surface runoff values varied up to 70% for different LULC data in the basin scale and more distinct variations at the subbasin scale. The surface runoff values were highest in the case of using GLCC and lowest in PELCOM case. We concluded that the LULC data is crucial for estimating surface runoff and peak flow, while it is less effective in estimating evapotranspiration and total water yield. Our results may guide hydrologic modelers in selecting LULC data for specific conditions and purposes.
MGSI：A few-shot relation extraction model based on multi-granularity semantic interaction
Authors: Zhao Guangda , He Xinyu , Li Shixin , Han Xue , Zhuang Qianjian , Ren Yonggong 
Published: July 2023

Abstract
Relation extraction is an important task in natural language processing, which aims to identify the semantic relationships between entities. Although the existing models excel with large datasets, the performance suffers when dealing with few-shot scenarios due to limited samples. Consequently, these models struggle to fully capture the semantics of the given text. To address these challenges, this paper proposes a few-shot relation extraction model based on multi-granularity semantic interaction. Our approach facilitates comprehensive semantic interaction between support instances, query instances, and relation descriptions to obtain sentence-level and word-level prototypes with varying levels of semantic granularity. These prototypes are then fused to generate the final prototype. Furthermore, our framework incorporates a target adaptation module and a semantic comparison module. These modules enhance the model's automatic adaptation and semantic understanding by capturing class-specific differences effectively. To validate the effectiveness of our proposed model, we conduct extensive experiments on the FewRel and FewRel2.0 public datasets. The experimental results support the validity of our proposed model.
Preferences of bereaved family members on communication with physicians when discontinuing anticancer treatment. - Referring to the concept of nudges
Authors: YOSHIDA Saran , HIRAI Kei , OHTAKE Fumio , MASUKAWA Kento , MORITA Tatsuya , KIZAWA Yoshiyuki , TSUNETO Satoru , SHIMA Yasuo , MIYASHITA Mitsunori 
Published: July 2023

Abstract
Purpose: This study aimed to clarify the situation and evaluate the communication on anticancer treatment discontinuation from the viewpoint of a bereaved family, in reference to the concept of nudges.
Methods: A multi-center questionnaire survey was conducted involving 350 bereaved families of patients with cancer admitted to palliative care units in Japan.
Results: The following explanations were rated as essential or very helpful: 1) anticancer treatment would be a physical burden for the patient (43.1%), 2) providing anticancer treatment was impossible (40.6%), 3) the disadvantages of undergoing treatment (40.6%), 4) not having the treatment would be better for the patient (40.6%), and 5) the advantages of not having the treatment (40.3%). The factors associated with a high need for improvement of the physician’s explanation included older age of the participant (β = 0.221, p = 0.010); lack of explanation that anticancer treatment cannot be given (β = 0.219, p = 0.001); and lack of explanation on the specific benefits of not having treatment (β = 0.251, p = 0.001).
Conclusion: Explaining the disadvantages of continuing anticancer treatment and the advantages of discontinuing treatment and presenting treatment discontinuation as the default option were effective in helping patients’ families in making the decision to discontinue treatment. In particular, explanation regarding the benefits of treatment discontinuation and show the discontinuation of anticancer treatment as the default option was considered important, as the lack of them caused a higher need for improvement.
Compulsory indications in hospital prescribing software tested with antibacterial prescriptions
Authors: Pairman Lorna , Chin Paul , Gardiner Sharon J , Doogue Matthew 
Published: July 2023

Abstract
Purpose
To assess and visualise how making the indication field compulsory in our electronic prescribing system influenced free text documentation.
Methods
This was a three-group prospective controlled study. In the intervention group of seven antibacterial medicines, the free text indication field was made compulsory in our electronic prescribing system. Text recorded in the indication field was manually classified as ‘indication present’, ‘other text’, ‘rubbish text’, or ‘blank’. The proportion of prescriptions with an indication for the seven antibacterials was compared with five antibacterials with and 72 without pre-existing compulsory indications for four weeks before and after the field was made compulsory. An interactive report was developed using a live data extract to illustrate indication provision for all medicines prescribed at our tertiary hospital.
Results
The proportion of prescriptions with an indication increased from 10.6–72.4% (p < 0.01) post-intervention. There was a 17.5% increase in ‘other text’ (p < 0.01), and 0.6% increase in ‘rubbish text’ (p < 0.01). Indications increased 2.7% (p < 0.01) in antibacterials without and 0.5% (p = 0.89) in antibacterials with pre-existing compulsory indications. The interactive report was validated and locally published.
Conclusion
Introducing a compulsory indication field in electronic prescriptions increased the proportion of indications documented substantially. There was only a small increase in ‘rubbish text’ reducing concern inaccurate information is recorded as a ‘workaround’ to the compulsory field. Interactive reports with live data support audit and quality improvement projects.
Does coping strategies play a mediating role in the relationship between disease management self-efficacy and mental toughness with the quality of life of cardiovascular patients?
Authors: Janjani Parisa , Nosrati Parisa , Ziapour Arash , Geravand Sahand , Moghadam Reza Heidari 
Published: July 2023

Abstract
Background
The present study was conducted with the aim of investigating the mediating role of coping strategies in relation to the self-efficacy for managing disease and mental toughness with the quality of life of cardiovascular patients.
Method
This was a descriptive-analytical cross-sectional study that was conducted in a specialized cardiology hospital in the west of Iran in 2022. The method of the present research is correlation structure analyses. Atotal of 313 eligible patients with coronary artery disease were included in the study. Coping strategies, self-efficacy for managing disease, mental toughness and quality of life questionnaires were used. After targeting 10 distorted questionnaires, 303 data were analyzed using SPSS version 26 and PLS_3 software.
Results
The results showed that self-efficacy and mental toughness are directly and indirectly related to the quality of life through the mediation of problem-oriented coping style, but SEM did not confirm this relationship through emotion-oriented coping style, and this relationship is not established. It was also found that heart patients with better self-efficacy for managing disease used more problem-oriented coping style, and their quality of life was reported to be higher.
Conclusion
The findings emphasize the importance of developing internal work models based on the type of coping strategies and the lifelong effects of these models on the quality of life of heart patients.
Physicochemical and Kinetic Properties of E-NTPDase Activity in Lymphocytes Isolated from Bone Marrow, Thymus and Mesenteric Lymph Nodes of Wistar Rats
Authors: Doleski Pedro Henrique , Cabral Fernanda Licker , Jantsch Matheus Henrique , Ebone Renan Silva , Adefegha Stephen Adeniyi , Leal Daniela Bitencourt Rosa , Schetinger Maria Rosa Chitolina 
Published: July 2023

Abstract

Plasma membrane anchored nucleotidases (E-ATPDases), as the E-NTPDase family, could hydrolyse and regulate the pericellular levels of nucleotides in lymphocytes. Each immune organ has a different microenvironment and display lymphocytes with different functions and phenotypes. Considering the different functions of each resident lymphocytes, the E-ATPDases activities in bone marrow (BML), thymus (TL) and mesenteric lymph node (MLL) lymphocytes of Wistar rats were characterized. The hydrolysis of extracellular nucleotides (eATP and eADP) showed linearity in time (0 to 120 min) and protein (1 to 6 μg protein) intervals. The optimal activity was attained at 37ºC in a pH value of 8.0. The essence of cofactor was shown by availability of Ca2+ or Mg2+ within the concentration range of 0 to 1000 µM in the reaction medium, with both ions showing similar effect. The Chevillard plot revealed that the hydrolysis of eATP and eADP occurred at the same active site of the enzyme. The analyses of E-ATPDases inhibitor and enzyme specificity showed possible actions of E-NTPDase isoforms -1 and -2 in the isolated cells. Furthermore, different kinetic behaviour of the nucleotide hydrolysis in each resident lymphocyte was observed in this study, as MLL showed the higher Vmax with the lowest km values, while TL had the lowest Vmax and high km values. The observed variation in enzyme activity of each resident lymphocyte may account for the different physiological signalling of nucleotides in each immune organ.
Evaluation of Antibody Drug Delivery Efficiency via Nebulizer in Various Airway Models and Breathing Patterns
Authors: Hong Soon Woo , Chang Kyung Hwa , Woo Chang Jae , Kim Ho Chul , Kwak Bong Seop , Park Bong Joo , Nam Ki Chang 
Published: July 2023

Abstract
Nebulizers are commonly used to treat respiratory diseases, which are a major cause of morbidity and mortality. While inhalation therapy with antibodies has been evaluated in preclinical studies and clinical trials for respiratory diseases, it has not yet been approved for treatment. Moreover, there is limited information regarding the delivery efficiency of therapeutic antibodies via nebulizer. In this study, the nebulization characteristics and drug delivery efficiencies were compared when immunoglobulin G (IgG) was delivered by five nebulizers using two airway models and five breathing patterns. The study confirmed that the delivered dose and drug delivery efficiency were reduced in the child model compared to those in the adult model and in the asthma pattern compared to those in the normal breathing pattern. The NE-SM1 NEPLUS vibrating mesh nebulizer demonstrated the highest delivery efficiency when calculated as a percentage of the loading dose, whereas the PARI BOY SX + LC SPRINT (breath-enhanced) jet nebulizer had the highest delivery efficiency when calculated as a percentage of the emitted dose. The results suggest that the total inspiration volume, output rate, and particle size should be considered when IgG nebulization is used. We, therefore, propose a method for testing the efficiency of nebulizer antibody delivery to predict delivered doses.
Effect of preoperative immunonutrition on postoperative short-term clinical outcomes in patients with gastric cancer cachexia: a prospective randomized controlled trial
Authors: Yu Junjian , Yuan Antai , Liu Qi , Dong Zhensheng , Li Zequn , Meng Cheng , Sun Yuqi , Jia Zhuoyu , Zhou Yanbing , Cao Shougen 
Published: July 2023

Abstract
Background: Although current guidelines recommend preoperative immunonutrition for cachectic gastric cancer patients, the strength of the recommendation is weak, and the level of evidence is low. The benefits of preoperative immunonutrition still remain controversial.
Patients and Methods: During the period from June 2022 to April 2023, 112 patients with gastric cancer cachexia were enrolled in the study and randomly assigned in a 1:1 ratio to receive either preoperative enteral immunonutrition support (IN, n=56) or standard enteral nutrition support (SEN, n=56). The primary endpoint was the incidence of infectious complications, and the secondary endpoints included the nutritional indicators, inflammatory markers, immune parameters, postoperative recovery and complications and astrointestinal intolerance reactions.
Results: The occurrence rate of infectious complications in patients who received preoperative immunonutrition support was significantly lower than that in the SEN group (21.4% vs 37.5%, P=0.040). The overall incidence of postoperative complications in the IN group was significantly lower than that in the SEN group (28.6% vs 44.6%, P=0.049). In terms of laboratory measurements, the IN group had significantly lower white blood cell (WBC) levels before surgery, on the first day after surgery, and on the fifth day after surgery compared to the SEN group (P=0.011; P=0.019; P=0.034). The IN group also had significantly lower serum C-reactive protein (CRP) levels before surgery, on the first day after surgery, and on the third day after surgery compared to the SEN group (P=0.005; P=0.017; P=0.042). On the third day after surgery, the IL-6 levels in the IN group were significantly lower than those in the SEN group. Furthermore, the IN group had significantly higher blood lymphocytes levels on the third and fifth day after surgery compared to the SEN group (P=0.016; P=0.011). The IN group also had significantly higher serum IgA levels before surgery and on the third day after surgery compared to the SEN group (P=0.048). In terms of clinical outcomes, the IN group had a shorter duration of antibiotic use (P=0.048), shorter hospital stay (P=0.018), and lower total hospital costs (P=0.034) compared to the SEN group. The IN group also experienced significantly less weight loss after surgery (P=0.043).
Conclusion: Preoperative administration of immunonutrition formula has a positive impact on the incidence of infectious complications in patients with gastric cancer cachexia after surgery. It improves patients' inflammatory and immune status, shortens hospital stays, and reduces healthcare costs. Preoperative use of immunonutrition may contribute to the improvement of prognosis in this high-risk population.
The risk of infective endocarditis according to blood pressure in patients with diabetes: a nationwide population-based study
Authors: Pyo Won Kyung , Kim Hee-Jung , Kim Jin Nam , Han Kyungdo , Lee Se Ju , Kim Jung Ho , Ku Nam Su , Lee Seung-Hyun 
Published: July 2023

Abstract
Background
We aimed to assess the incidence of infective endocarditis (IE) and evaluate the impact of hypertension (HTN) with underweight on the risk of IE among patients with diabetic mellitus (DM) using a nationwide population-based cohort in Korea.
Methods
We identified 2,603,012 participants (57.4 ± 12.3 years) in the national health insurance database. Of these, 374,586 were normotensive, 750,006 were at pre-HTN status, and the remainder had HTN. The risk of IE was compared between the groups, and the impact of being underweight (body mass index < 18.5) was also evaluated.
Results
During follow-up (7.14 years; interquartile range 6.01–8.08 years), 1,703 cases of IE occurred; 168 (0.0647 person per 1000 person-years [PY]), 303 (0.05836 per 1000 PY), and 1,232 (0.12235 per 1000 PY) in normotensive, pre-HTN and HTN group, respectively. Hypertensive participants presented a higher risk of IE (hazard ratio, 1.360; 95% confidence interval, 1.152–1.607) than normotensive participants. Being underweight increased the risk of IE by 90% among subjects with HTN. In subgroup analysis, age, duration of DM, insulin use, and habitual factors were not associated with the incidence of IE.
Conclusions
Diabetic patients may require rigorous blood pressure control and simultaneous avoidance of excessive weight loss to prevent IE.
Fluoroscopic Localization of L3 Sympathetic Ganglion Prior to Endoscopic Lumbar Sympathectomy
Authors: Kusakavitch Melanie , Talsma Joel , Idowu Olajire , Kim Sunghoon 
Published: July 2023

Abstract
Purpose: Plantar hyperhidrosis can cause a significant impact on an individual's quality of life. Surgical treatment of plantar hyperhidrosis involves blocking the lumbar sympathetic signals from reaching the plantar surface by placing a metal clip above the third lumbar ganglion. We hypothesize that by mapping the location of the third lumbar ganglion and correlating it with a fluoroscopic image of the lumbar spine will improve the level accuracy of lumbar sympathectomy.
METHODS: Ten human cadavers were dissected to define the locations of lumbar sympathetic ganglia, and fluoroscopic images of lumbar spine were obtained.
RESULTS: For the right L3 sympathetic ganglion most common locations corresponded with the upper 1/3 of the L3 vertebral body 36.4%, and the next most common location corresponded to the lower 1/3 of the L2 vertebral body 27.3%. The left L3 sympathetic ganglion the most common sites corresponded with the upper 1/3 of the L3 vertebral body 36.4% and the middle 1/3 of the L3 vertebral body 36.4%.
CONCLUSION: The L3 ganglion is consistently found next to either L2 or L3 vertebrae.
A Novel Optic Disc and Optic Cup Segmentation in a Fundus Image using CNN based hybrid CAG-SEPPSM
Authors: Elizabeth J. Ruby , Kesavaraja D. , Juliet S. Ebenezer 
Published: July 2023

Abstract
Segmentation is one of the most significant processes in identifying the diseases. Glaucoma disease is detected by segmenting Optic Disc (OPdisc) and Optic Cup (OPcup) from a fundus image. In disease detection method, accuracy of segmentation plays a vital role. Segmentation process is more time consuming task because of large dataset. For avoiding that, an automatic segmentation tool is needed. In this paper, the automatic segmentation is proposed through a Deep Learning based CNN model. The OPdisc and OPcup are segmented by using a hybrid Channel Attention Gate- Squeeze Excitation Parallel Pooling Statistical Map (CAG-SEPPSM) embedded using Convolutional Neural Networks (CNN). In segmentation of OPdisc, a new Attention Gate and in segmentation of OPcup, Squeeze-Excitation Parallel Pooling Statistical Map block was developed. The dataset which are used for testing the proposed method are DRISHTI-GS database and RIM-ONE v.3 database. The proposed segmentation method outperform when compared to the existing methods in terms of Dice Coefficient (DC), Intersection Over Union (IOU) and Accuracy.