bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forcing generalised quasirandom graphs efficiently
Authors: Grzesik Andrzej , Král’ Daniel , Pikhurko Oleg 
Published: September 2023

AbstractWe study generalised quasirandom graphs whose vertex set consists of$q$parts (of not necessarily the same sizes) with edges within each part and between each pair of parts distributed quasirandomly; such graphs correspond to the stochastic block model studied in statistics and network science. Lovász and Sós showed that the structure of such graphs is forced by homomorphism densities of graphs with at most$(10q)^q+q$vertices; subsequently, Lovász refined the argument to show that graphs with$4(2q+3)^8$vertices suffice. Our results imply that the structure of generalised quasirandom graphs with$q\ge 2$parts is forced by homomorphism densities of graphs with at most$4q^2-q$vertices, and, if vertices in distinct parts have distinct degrees, then$2q+1$vertices suffice. The latter improves the bound of$8q-4$due to Spencer.
Modeling the development of cognitive reserve in children: A residual index approach
Authors: Irani Zubin A. , Sheridan Andrew M. C. , Silk Timothy J. , Anderson Vicki , Weinborn Michael , Gavett Brandon E. 
Published: September 2023

AbstractObjective:To model cognitive reserve (CR) longitudinally in a neurodiverse pediatric sample using a residual index approach, and to test the criterion and construct validity of this index.Method:Participants were N = 115 children aged 9.5–13 years at baseline (MAge = 10.48 years, SDAge = 0.61), and n = 43 (37.4%) met criteria for ADHD. The CR index represented variance in Matrix Reasoning scores from the WASI that was unexplained by MRI-based brain variables (bilateral hippocampal volumes, total gray matter volumes, and total white matter hypointensity volumes) or demographics (age and sex).Results:At baseline, the CR index predicted math computation ability (estimate = 0.50, SE = 0.07, p < .001), and word reading ability (estimate = 0.26, SE = 0.10, p = .012). Longitudinally, change in CR over time was not associated with change in math computation ability (estimate = −0.02, SE = 0.03, p < .513), but did predict change in word reading ability (estimate = 0.10, SE = 0.03, p < .001). Change in CR was also found to moderate the relationship between change in word reading ability and white matter hypointensity volume (estimate = 0.10, SE = 0.05, p = .045).Conclusions:Evidence for the criterion validity of this CR index is encouraging, but somewhat mixed, while construct validity was evidenced through interaction between CR, brain, and word reading ability. Future research would benefit from optimization of the CR index through careful selection of brain variables for a pediatric sample.
Revisiting Knowledge-for-Development
Authors: Jacquet Pierre 
Published: September 2023

AbstractThe Knowledge-for-Development (K4D) approach has been characterized by a marked concentration of the production of research on development in developed countries. The underlying utilitarian approach to social science research misrepresents the nature and making of policy, raises entry barriers for developing country researchers, and focuses on the production of research to the detriment of its use. Using such research in developing countries requires informed debate, consideration of the local environment, and sufficient local research capacity. Foreign assistance should focus on research capacity building as a specific objective, distinct from the production and publication of research, with its own management, implementation, and monitoring. This is essential if the objective of the K4D approach, namely the better use of scientific knowledge to enhance the quality of policies, is to be achieved.
Is Using Trade Policy for Foreign Policy a ‘SNO Job’? On Linkage, Friend-Shoring, and the Challenges for Multilateralism
Authors: Wolfe Robert 
Published: September 2023

AbstractUsing trade policy to achieve foreign policy objectives, such as stable international relations, has a long history, from Kant to the founders of the GATT. Punishing enemies and rewarding ‘friends’ by granting or withholding market access is also not new, and sanctions or blockades are a venerable form of trade policy used as foreign policy. A more recent form is influencing the domestic policy of another country with non-commercial provisions in trade agreements. All these tools are based on linkage, on the assumption that a desired outcome can be achieved by interventions that would increase or decrease trade. The latest instance is so-called ‘friend-shoring’, which would in principle isolate enemies, although it will be difficult in practice and risks undermining multilateralism. The cost of these interventions is susceptible to economic analysis, even if the conclusion is that it is worth paying. Influenced by Alan Winters who referred to national security as a motivation for agriculture protection as a ‘so-called non-economic objective’ or SNO, I argue that using a trade policy tool for a foreign policy purpose as if there is no cost is a SNO job, an attempt to justify an intervention aimed at one objective by framing it as being valuable for another.
Climate Equivalence and International Trade
Authors: Lydgate Emily 
Published: September 2023

AbstractThis article examines a significant question in navigating trade and climate tension: how to recognize another country as having equivalent climate regulations. Such equivalence forms a core component of many proposed models of so-called climate clubs. Establishing equivalence between distinct national climate regulation regimes poses a unique challenge that draws upon both trade and environmental international cooperation. Drawing on existing proposals, I examine prospects for country-based cooperation through three models: ETS-linking, benchmarking of shared methods and minimum standards, and benchmarking of outcome duties. The analysis concludes that all models necessitate some trade-offs between the goals of rigorous oversight of climate objectives, inclusivity, and WTO compliance. Benchmarking of shared methods and minimum standards seems most feasible, and would provide a deeper level of integration between trade and climate cooperation, but necessitates a shift in how countries, particularly the EU, oversee regulatory compliance.
Exporting and Technology Adoption in Brazil
Authors: Cirera Xavier , Comin Diego , Cruz Marcio , Lee Kyung Min , Martins-Neto Antonio 
Published: September 2023

AbstractThere is limited evidence about the role that participating in international trade has on the diffusion of technologies. This paper analyzes the impact of exporting on firms’ adoption of technologies that are more sophisticated, using a novel dataset, the Firm-level Adoption of Technology (FAT) survey, that includes more than 1,500 firms from Brazil. The survey provides detailed information about the use of more than 300 technologies, combined with data from Brazil's census of formal workers (RAIS) and Brazil’s exports data from the Ministry of Trade. To address some critical endogeneity concerns, we apply a difference-in-differences estimation with multiple periods to examine the effects of entering export markets on technology adoption. We find that exporting has positive effects on firms’ likelihood of adopting advanced technologies in business functions related with business administration, production planning, supply chain management, and quality control, which are important to manage tasks associated to export activities.
The Bank, the Fund, and the GATT: Which Institution Most Supported Developing-Country Trade Reform?
Authors: Irwin Douglas A. 
Published: September 2023

AbstractThe 1980s and 1990s saw a policy revolution in developing countries in which many highly protected (if not closed) economies were opened to world trade. These reforms were largely undertaken unilaterally, but international economic institutions such as the World Bank, the International Monetary Fund, and the General Agreement on Tariffs and Trade/World Trade Organization supported these efforts. This paper examines the ways in which these institutions promoted, or failed to promote, trade policy reform during this pivotal period.
Measuring Support for Welfare Policies: Implications for the Effects of Race and Deservingness Stereotypes
Authors: Zhirkov Kirill , Lunz Trujillo Kristin , Myers C. Daniel 
Published: September 2023

AbstractWhat are the relative contributions of stereotypes about the race and deservingness of welfare recipients to Americans’ opinions on welfare? A recent study employing a conjoint-experimental method finds that Americans’ stereotypes of welfare recipients as undeserving drive negative attitudes toward welfare, while stereotypes of welfare recipients as Black have little effect. However, this finding may be produced by the measure of welfare attitudes that includes questions implicating deservingness. We implement a conceptual replication of that study using different measures of welfare policy opinions that directly ask respondents about spending, both on welfare generally and on specific welfare programs. We show that when support for welfare is measured using the spending questions, stereotypes about race are significantly associated with opposition to welfare. These results have important implications for the debate on Americans’ opposition to welfare programs, as well as for the measurement of policy opinions in surveys.
Increasing Risks of Future Compound Climate Extremes With Warming Over Global Land Masses
Authors: Wu Haijiang , Su Xiaoling , Singh Vijay P. 
Published: September 2023

AbstractCompound climate extremes (here referred to compound dry–hot events and compound pluvial–hot events) result in devastating disasters which threaten water‐food‐energy security. However, in a warming scenario, the risk of occurrence, the quantification of uncertainty, and associated drivers of compound climate extremes—particularly compound pluvial–hot events—have not been fully explored. By leveraging climate model large ensembles, it is revealed that the risk of compound climate extremes is projected to increase 2–3 times over most global land masses in future Representative Concentration Pathway (RCP) 8.5 forcing compared with historical forcing. Increased risks of compound climate extremes are mainly attributed to the changes in temperature and changes in dependence between precipitation and temperature, while the change in precipitation contributing to risk of these two compound climate extremes exhibits approximately spatial complementary. In the warming world, the hot spots of compound dry–hot extremes mainly lie in Europe, South Africa, and the Amazon, while those of compound pluvial–hot extremes mostly lie in the eastern USA, eastern and southern Asia, Australia, and central Africa. These findings help stakeholders and decision makers develop a package of climate change adaptation strategies to manage and mitigate the risk of compound climate extremes.
Overrepresentation of Historically Underserved and Socially Vulnerable Communities Behind Levees in the United States
Authors: Vahedifard Farshid , Azhar Mohammed , Brown Dustin C. 
Published: September 2023

AbstractInfrastructure equity is an immediate concern with levees, constituting the backbone of the U.S. protection against flooding. Flooding patterns are exacerbated by anthropogenic climate change in several regions, posing a significant risk to the economy, safety, and well‐being of the nation. The evolving risk of flooding is shown to disproportionately affect historically underserved and socially vulnerable communities (HUSVCs). Here we compare the sociodemographic and socioeconomic composition of leveed and non‐leveed U.S. communities and show a substantial overrepresentation of HUSVCs in leveed areas at the state, regional, and national levels. Further, we analyze the proportion of communities designated as “disadvantaged” in leveed versus non‐leveed areas, revealing a substantially larger population of disadvantaged communities residing behind levees. Our analyses show that nationally, Hispanic are the most overrepresented population in leveed areas yielding a disparity percentage of 39.9%, followed by Native American (18.7%), Asian (17.7%), and Black (16.1%) communities. Communities characterized by low education, poverty, and disability exhibit a disproportionately higher presentation of 27.8%, 20.4%, and 5.4% in leveed areas across the U.S. In 43 states, disadvantaged communities are overrepresented behind levees, with a national disparity percentage of 40.6%. At the regional level, the highest disparity was observed in the Northeast (57.3%), followed by the West (51.3%), Southeast (38%), Midwest (29.2%), and Southwest (25%). The findings can enable decision‐ and policy‐makers to identify hotspots within HUSVCs that need to be prioritized for enhancing the integrity and climate adaptation of their levee systems.
A first-in-class fully modified version of miR-34a with outstanding stability, activity, and anti-tumor efficacy
Authors: Abdelaal Ahmed M. , Sohal Ikjot S. , Iyer Shreyas , Sudarshan Kasireddy , Kothandaraman Harish , Lanman Nadia A. , Low Philip S. , Kasinski Andrea L. 
Published: September 2023

AbstractAltered by defects in p53, epigenetic silencing, and genomic loss, the microRNA miR-34a represents one of the most clinically relevant tumor-suppressive microRNAs. Without question, a striking number of patients with cancer would benefit from miR-34a replacement, if poor miR-34a stability, non-specific delivery, and delivery-associated toxicity could be overcome. Here, we highlight a fully modified version of miR-34a (FM-miR-34a) that overcomes these hurdles when conjugated to a synthetically simplistic ligand. FM-miR-34a is orders of magnitude more stable than a partially modified version, without compromising its activity, leading to stronger repression of a greater number of miR-34a targets. FM-miR-34a potently inhibited proliferation and invasion, and induced sustained downregulation of endogenous target genes for >120 h following in vivo delivery. In vivo targeting was achieved through conjugating FM-miR-34a to folate (FM-FolamiR-34a), which inhibited tumor growth leading to complete cures in some mice. These results have the ability to revitalize miR-34a as an anti-cancer agent, providing a strong rationale for clinical testing.
Predictive factors of medium-giant coronary artery aneurysms in Kawasaki disease
Authors: Jiang Saitong , Li Meng , Xu Kun , Xie Ying , Liang Piaohong , Liu Cong , Su Qiru , Li Boning 
Published: September 2023

Abstract
Background
We aimed to examine predictive measures for medium and giant coronary artery aneurysms (CAA) in Kawasaki disease (KD) patients.

Methods
Patients who were diagnosed with KD from 2015 to 2021 were retrospectively reviewed. The clinical and laboratory data were compared between medium-giant group and non-medium-giant group.

Results
A total of 1331 KD patients were investigated, of whom 63 patients (4.7%) developed medium-giant CAA including 27 patients (2%) with giant CAA. Sex, age, fever duration, intravenous immunoglobulin (IVIG) resistance, platelet count, and albumin level independently predicted medium or giant CAA by multivariate logistic regression analysis. Male, age, duration of fever, IVIG resistance, platelet count, hemoglobin, and erythrocyte sedimentation rate were independent predictors for giant CAA. The two new scoring systems using these factors in identifying patients with medium-giant CAA and giant CAA had respectively sensitivities of 86.89% and 92.59%, and specificities of 81.65% and 87.93%. Validation in 2021 dataset (193 KD patients) showed comparable sensitivity and specificity to development dataset.

Conclusions
Male, age, fever duration, IVIG resistance, platelet count, albumin, hemoglobin, and erythrocyte sedimentation rate might be significant predictors of medium and giant CAA. The sensitivity and specificity in our risk prediction model were higher than in previous research.

Impact

This is the first study to search for risk factors and establish a prediction model for the development of medium-giant CAA in the Chinese population using z-scores and absolute inner diameter values based on large sample sizes.

The sensitivity and specificity in our model were higher than in previous studies.

Our research could help clinicians better predict medium-giant CAA and choose more appropriate treatment.
Antarctic evidence for an abrupt northward shift of the Southern Hemisphere westerlies at 32 ka BP
Authors: Venugopal Abhijith U. , Bertler Nancy A. N. , Severinghaus Jeffrey P. , Brook Edward J. , Cortese Giuseppe , Lee James E. , Blunier Thomas , Mayewski Paul A. , Kjær Helle A. , Carter Lionel , Weber Michael E. , Levy Richard H. , Pyne Rebecca L. , Vandergoes Marcus J. 
Published: September 2023

AbstractHigh-resolution ice core records from coastal Antarctica are particularly useful to inform our understanding of environmental changes and their drivers. Here, we present a decadally resolved record of sea-salt sodium (a proxy for open-ocean area) and non-sea salt calcium (a proxy for continental dust) from the well-dated Roosevelt Island Climate Evolution (RICE) core, focusing on the time period between 40–26 ka BP. The RICE dust record exhibits an abrupt shift towards a higher mean dust concentration at 32 ka BP. Investigating existing ice-core records, we find this shift is a prominent feature across Antarctica. We propose that this shift is linked to an equatorward displacement of Southern Hemisphere westerly winds. Subsequent to the wind shift, data suggest a weakening of Southern Ocean upwelling and a decline of atmospheric CO2 to lower glacial values, hence making this shift an important glacial climate event with potentially important insights for future projections.
Large-scale assembly of isotropic nanofiber aerogels based on columnar-equiaxed crystal transition
Authors: Li Lei , Zhou Yiqian , Gao Yang , Feng Xuning , Zhang Fangshu , Li Weiwei , Zhu Bin , Tian Ze , Fan Peixun , Zhong Minlin , Niu Huichang , Zhao Shanyu , Wei Xiaoding , Zhu Jia , Wu Hui 
Published: September 2023

AbstractIce-templating technology holds great potential to construct industrial porous materials from nanometers to the macroscopic scale for tailoring thermal, electronic, or acoustic transport. Herein, we describe a general ice-templating technology through freezing the material on a rotating cryogenic drum surface, crushing it, and then re-casting the nanofiber slurry. Through decoupling the ice nucleation and growth processes, we achieved the columnar-equiaxed crystal transition in the freezing procedure. The highly random stacking and integrating of equiaxed ice crystals can organize nanofibers into thousands of repeating microscale units with a tortuous channel topology. Owing to the spatially well-defined isotropic structure, the obtained Al2O3·SiO2 nanofiber aerogels exhibit ultralow thermal conductivity, superelasticity, good damage tolerance, and fatigue resistance. These features, together with their natural stability up to 1200 °C, make them highly robust for thermal insulation under extreme thermomechanical environments. Cascading thermal runaway propagation in a high-capacity lithium-ion battery module consisting of LiNi0.8Co0.1Mn0.1O2 cathode, with ultrahigh thermal shock power of 215 kW, can be completely prevented by a thin nanofiber aerogel layer. These findings not only establish a general production route for nanomaterial assemblies that is conventionally challenging, but also demonstrate a high-energy-density battery module configuration with a high safety standard that is critical for practical applications.
Neutrophil metalloproteinase driven spleen damage hampers infection control of trypanosomiasis
Authors: Pham Hien Thi Thu , Magez Stefan , Choi Boyoon , Baatar Bolortsetseg , Jung Joohee , Radwanska Magdalena 
Published: September 2023

AbstractRecent blood transcriptomic analysis of rhodesiense sleeping sickness patients has revealed that neutrophil signature genes and activation markers constitute the top indicators of trypanosomiasis-associated inflammation. Here, we show that Trypanosoma brucei infection results in expansion and differentiation of four splenic neutrophil subpopulations, including Mki67+Birc5+Gfi1+Cebpe+ proliferation-competent precursors, two intermediate immature subpopulations and Cebpb+Spi1+Irf7+Mcl1+Csf3r+ inflammation reprogrammed mature neutrophils. Transcriptomic scRNA-seq profiling identified the largest immature subpopulation by Mmp8/9 positive tertiary granule markers. We confirmed the presence of both metalloproteinases in extracellular spleen homogenates and plasma. During infection, these enzymes digest extracellular matrix components in the absence of sufficient TIMP inhibitory activity, driving remodeling of the spleen follicular architecture. Neutrophil depletion prevents the occurrence of organ damage, resulting in increased plasma cell numbers and prolonged host survival. We conclude that trypanosomiasis-associated neutrophil activation is a major contributor to the destruction of the secondary lymphoid architecture, required for maintaining an efficient adaptive immune response.
Survey of open science practices and attitudes in the social sciences
Authors: Ferguson Joel , Littman Rebecca , Christensen Garret , Paluck Elizabeth Levy , Swanson Nicholas , Wang Zenan , Miguel Edward , Birke David , Pezzuto John-Henry 
Published: September 2023

AbstractOpen science practices such as posting data or code and pre-registering analyses are increasingly prescribed and debated in the applied sciences, but the actual popularity and lifetime usage of these practices remain unknown. This study provides an assessment of attitudes toward, use of, and perceived norms regarding open science practices from a sample of authors published in top-10 (most-cited) journals and PhD students in top-20 ranked North American departments from four major social science disciplines: economics, political science, psychology, and sociology. We observe largely favorable private attitudes toward widespread lifetime usage (meaning that a researcher has used a particular practice at least once) of open science practices. As of 2020, nearly 90% of scholars had ever used at least one such practice. Support for posting data or code online is higher (88% overall support and nearly at the ceiling in some fields) than support for pre-registration (58% overall). With respect to norms, there is evidence that the scholars in our sample appear to underestimate the use of open science practices in their field. We also document that the reported lifetime prevalence of open science practices increased from 49% in 2010 to 87% a decade later.
Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts
Authors: Rodríguez-Hernández Diego , Vijayan Kamalakannan , Zigweid Rachael , Fenwick Michael K. , Sankaran Banumathi , Roobsoong Wanlapa , Sattabongkot Jetsumon , Glennon Elizabeth K. K. , Myler Peter J. , Sunnerhagen Per , Staker Bart L. , Kaushansky Alexis , Grøtli Morten 
Published: September 2023

AbstractDrugs targeting multiple stages of the Plasmodium vivax life cycle are needed to reduce the health and economic burdens caused by malaria worldwide. N-myristoyltransferase (NMT) is an essential eukaryotic enzyme and a validated drug target for combating malaria. However, previous PvNMT inhibitors have failed due to their low selectivity over human NMTs. Herein, we apply a structure-guided hybridization approach combining chemical moieties of previously reported NMT inhibitors to develop the next generation of PvNMT inhibitors. A high-resolution crystal structure of PvNMT bound to a representative selective hybrid compound reveals a unique binding site architecture that includes a selective conformation of a key tyrosine residue. The hybridized compounds significantly decrease P. falciparum blood-stage parasite load and consistently exhibit dose-dependent inhibition of P. vivax liver stage schizonts and hypnozoites. Our data demonstrate that hybridized NMT inhibitors can be multistage antimalarials, targeting dormant and developing forms of liver and blood stage.