bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘We are in for a culture change’: continuing professional development leaders’ perspectives on COVID-19, burn-out and structural inequities
Authors: Soklaridis Sophie , Zaheer Rabia , Scully Michelle , Shier Rowen , Williams Betsy , Dang Linda , Daniel Sam J , Sockalingam Sanjeev , Tremblay Martin 
Published: September 2023

IntroductionThe COVID-19 pandemic positioned healthcare systems in North America at the epicentre of the crisis, placing inordinate stress on clinicians. Concurrently, discussions about structural racism, social justice and health inequities permeated the field of medicine, and society more broadly. The confluence of these phenomena required rapid action from continuing professional development (CPD) leaders to respond to emerging needs and challenges.MethodsIn this qualitative study, researchers conducted 23 virtual semistructured interviews with CPD leaders in Canada and the USA. Interview audiorecordings were transcribed, deidentified and thematically analysed.ResultsThis study revealed that the CPD leaders attributed the pandemic as illuminating and exacerbating problems related to clinician wellness; equity, diversity and inclusion; and health inequities already prevalent in the healthcare system and within CPD. Analysis generated two themes: (1) From heroes to humans: the shifting view of clinicians and (2) Melding of crises: an opportunity for systemic change in CPD.DiscussionThe COVID-19 pandemic increased recognition of burn-out and health inequities creating momentum in the field to prioritise and restrategise to address these converging public health crises. There is an urgent need for CPD to move beyond mere discourse on these topics towards holistic and sustainable actionable measures.
HLA-B27 status and inflammatory MRI lesions of the sacroiliac joints: a post hoc analysis in patients without axial spondyloarthritis
Authors: Ulas Sevtap Tugce , Proft Fabian , Diekhoff Torsten , Rios Rodriguez Valeria , Rademacher Judith , Poddubnyy Denis , Ziegeler Katharina 
Published: September 2023

ObjectiveThe assessment of inflammatory and structural lesions in the sacroiliac joint (SIJ) is crucial in axial spondyloarthritis (axSpA). HLA-B27 status plays an important role in axSpA diagnosis and has been linked to MRI lesion burden in the general population. We aimed to investigate the sex-specific influence of HLA-B27 status on inflammatory and structural MRI findings in patients with low back pain of non-inflammatory origin.MethodsThis post hoc analysis included 139 non-axSpA patients (90 women) with chronic low back pain. Two readers scored MRIs of the SIJ for the presence of sclerosis, erosion, fat metaplasia, bone marrow oedema (BMO) and ankylosis. Frequencies and extent of lesions were compared regarding the HLA-B27 status using χ2tests and t-tests. Regression models to assess the sex-dependent influence of HLA-B27 on lesion burden were computed.ResultsHLA-B27 was positive in 33 women (36.7%) and 23 men (46.9%). The overall occurrence of all SIJ lesions did not differ in HLA-B27 negative and positive individuals. There were no significant differences in the extent of lesions considering the HLA-B27 positivity, for erosion (mean sum score (MSS) of 0.91 vs 0.48; p=0.144), sclerosis (MSS 1.65 vs 1.88; p=0.576), fat metaplasia (MSS 0.56 vs 0.27; p=0.425), BMO (MSS 0.75 vs 0.59; p=0.460) and ankylosis (MSS 0.06 vs 0.04; p=0.659).ConclusionHLA-B27 status has no significant influence on the occurrence and extent of SIJ lesions in patients with low back pain of non-inflammatory origin in either men or women.
Circuit complexity for coherent-thermal states in bosonic string theory
Authors: Shabir Arshid , Dey Sanjib , Wani Salman Sajad , Lone Suhail , Rubab Seemin , Faizal Mir 
Published: September 2023

AbstractIn this paper, we first construct thermofield double states for bosonic string theory in the light-cone gauge. We then obtain a coherent-thermal string state and a thermal-coherent string state. We use the covariance matrix approach to calculate the circuit complexity of coherent-thermal string states. In this approach, we generate the optimal geodesics by a horizontal string generator, and then obtain the circuit complexity using the length of the minimal geodesics in the group manifold.
Unified Fair Allocation of Goods and Chores via Copies
Authors: Gafni Yotam , Huang Xin , Lavi Ron , Talgam-Cohen Inbal 
Published: September 2023

We consider fair allocation of indivisible items in a model with goods, chores, and copies, as a unified framework for studying: (1) the existence of EFX and other solution concepts for goods with copies; (2) the existence of EFX and other solution concepts for chores. We establish a tight relation between these issues via two conceptual contributions: First, a refinement of envy-based fairness notions that we term envy
without commons
(denoted EFX
WC
when applied to EFX). Second, a formal
duality theorem
relating the existence of a host of (refined) fair allocation concepts for copies to their existence for chores. We demonstrate the usefulness of our duality result by using it to characterize the existence of EFX for chores through the dual environment, as well as to prove EFX existence in the special case of leveled preferences over the chores. We further study the hierarchy among envy-freeness notions without commons and their α-MMS guarantees, showing, for example, that any EFX
WC
allocation guarantees at least

\(\frac{4}{11}\)

-MMS for goods with copies.
The Effects of Charter High Schools on Academic Achievement and College Enrollment: Evidence from Los Angeles
Authors: Reber Sarah J. , Rünger Dennis , Wong Mitchell D. 
Published: September 2023

Abstract
This paper estimates the causal effects of enrollment in one of five oversubscribed high-quality Los Angeles charter schools using a lottery design. Enrolling in a charter school increased eleventh-grade standardized test scores and enrollment and persistence in four-year colleges substantially, but had no effect on high school GPA. Charter students took more advanced coursework, were less likely to skip class, were more likely to apply to a four-year college, and reported more teacher support for college-going. The increase in four-year persistence appears to be driven by more enrollment and persistence in University of California campuses, which have higher graduation rates than the likely alternatives. This suggests that the effects of charter schools could depend on the availability of high graduation rate colleges.
School District Borrowing and Capital Spending: The Effectiveness of State Credit Enhancement
Authors: Yang Lang (Kate) 
Published: September 2023

Abstract
School districts in the United States often borrow on the municipal bond market to pay for capital projects. Districts serving economically disadvantaged communities tend to receive lower credit ratings and pay higher interest rates. To remedy this problem, twenty-four states have established credit enhancement programs that promise to repay district debt when a district cannot do so, thereby enhancing the district's credit rating. With a generalized difference-in-differences approach, I rely on cross- and within-district variations to estimate the effect of state enhancement on district bond interest rate, per-pupil capital spending, and student performance. State enhancement reduces district bond interest rates by 6 percent and increases per-student capital spending by 2 percent to 7 percent. It also reduces the disparity in the interest rate and capital spending across districts serving lower- and higher-income families, with no discernible effect on test scores. I find no evidence that the amount of enhanced school debt is associated with significant changes in interest rates paid by state governments. Districts in states without such programs could have achieved cost savings in the range of $383 million to $1 billion from 2009 to 2019 had the states adopted similar programs.
Hidden in Plain Sight: Saul’s Male Trauma Narrative in 1 Samuel
Authors: Thiede Barbara 
Published: September 2023

Abstract
King Saul’s story is not simply a tool for justifying Yhwh’s decision to promote David in his place; it is a narrative of trauma that demonstrates how biblical hegemonic masculinity normalizes sexual violence perpetrated by men against men. Saul is the victim of repeated and sexualized assault by a controlling, coercive deity. After such attacks Saul loses control over his speech, his mind, and his body. He experiences dissociation, helplessness, terror, and rage. In abusing Saul, Yhwh is aided and abetted by Samuel and by David. The sexualized violence Saul experiences marks him and silences him; just before he dies, he a makes a single allusion to the trauma he long endured by invoking the rape he fears at the hands of the Philistines. In fact, after his death, Saul is metaphorically raped, his body stripped, decapitated, impaled, and displayed. He is no trauma survivor, but its victim.
Do Electronic Services Improve Students’ Satisfaction among Public Sector Organizations? The Case of Tanzanian Higher Learning Institutions
Authors: John Yuslida 
Published: September 2023

Abstract
This study examines the influence of e-services on students’ satisfaction in higher learning institutions. Although many studies have investigated e-services in education systems, many of them do not associate satisfactory e-services application in administrative activities in ensuring students’ satisfaction. The surveyed data collected from 257 university students was analyzed by the structural equation method (SEM). The study found students are satisfied with e-service provision when the systems are simple to use, reliable, efficient, secured, time-saving, and reduce costs in the process of registration, payment of tuition fees, and accessing online library services.
Rached Ghannouchi and his Political Discourses between Tunisian and Global Islamism
Authors: Anas Omair 
Published: September 2023

Abstract
Rached Ghannouchi and his Islamic movement Ennahda had received a popular mandate to write a post-revolution constitution for Tunisia. However, Ghannouchi preferred national consensus over using his party’s political strength. Ennahda relinquished power in 2014 and announced to abandon religious activism in 2016. The paper explains Ghannouchi’s politics of Islam, which he now calls, “Muslim Democracy (Ghannouchi, 2016),” and his thoughts on key modern political concepts. Ghannouchi, instead of a Sharia state, advanced the agenda of Dawla Madniya or Civilian State (Zidan, 2014). Ghannouchi, in his pre-uprising writings, has widely discussed ‘state,’ ‘secularism,’ ‘democracy,’ ‘civilization,’ and fundamental human rights. Ghannouchi sought national consensus by sharing a common viewpoint for Tunisia’s transition from dictatorship to a civilian state. The article analyses Ghannouchi’s writings and his opinion on key Islamic issues on which he differs from contemporary Islamic groups of Egypt, Pakistan, Iran, or elsewhere.
Outcomes of Surgically Treated Purely Ligamentous Stage II Lisfranc Injuries
Authors: Urdahl Torben H. , Dock Carissa C. , Stone McGaver Rebecca , Seiffert Kayla J. , Coetzee J. Chris 
Published: September 2023

Background: Low-energy stage II Lisfranc injuries are rare, and treatment can be operative or nonoperative based on a surgeon’s assessment of midfoot stability. No previously published patient-reported outcome measures (PROMs) data for Lisfranc injuries isolates purely ligamentous stage II injuries. The purpose of this study was to analyze PROMs for patients who underwent operative management of stage II Lisfranc injuries. Methods: Thirty-nine patients (39 feet) with confirmed Nunley-Vertullo stage II Lisfranc injuries between May 2012 and February 2022 were identified through a retrospective chart review. PROMs that were analyzed were the visual analog scale (VAS) pain scale, Veterans RAND 12-Item Health Survey (VR-12), Foot and Ankle Ability Measure (FAAM), and patient satisfaction. Results: Thirty-two open reduction internal fixations (ORIFs) and 7 fusions were performed. The mean latest follow-up was 44.6 (range, 12-92) months. There were 2 complications (5%, 2/39) that required a revision procedure. Twenty-six patients (67%, 26/39) underwent secondary surgery to remove retained hardware. The mean time to hardware removal was 3.97 (range, 2.70-7.47) months. The overall mean patient satisfaction score with overall medical care including clinical visits and interactions with medical staff personnel was 93.6/100. All PROMs (VAS, VR-12, FAAM) demonstrated statistically significant improvement ( P < .05) from preoperative (injury) values to latest follow-up postinjury values. Conclusion: Patients who were treated surgically with stage II purely ligamentous Lisfranc injuries via the methods used were found to mostly undergo hardware removal and have high levels of overall satisfaction with their process of medical care. Level of Evidence: Level IV, retrospective case series.
A Longitudinal Seroconversion Panel Shows Anti-SARS-CoV-2 Antibody Levels up to 6.5 Months After Vaccination with mRNA-1273 (Moderna)
Authors: Belda Francisco , Mora Oscar , Christie Rebecca , Crowley Michael 
Published: September 2023

BACKGROUND Vaccines have emerged as a crucial tool in combatting the COVID-19 pandemic particularly those based on SARS-CoV-2 S-protein mRNA. A crucial aspect of vaccine efficacy is the duration of antibody responses. In this study, a seroconversion panel was created to assess antibody responses to the mRNA-1273 vaccine over time (6.5 months). METHODS Blood samples collected from 15 healthy adult participants prior to and up to 6.5 months after vaccination with the mRNA-1273 vaccine (Moderna). Serum from these blood samples were analyzed for anti-SARS-CoV-2 antibody activity by chemiluminescent immunoassay. RESULTS The immunoassay results showed that one participant was positive for anti-SARS-CoV-2 antibodies prior to vaccination indicating a prior infection. All participants showed a positive antibody response after the first vaccination. Highest antibody responses were seen after the second dose (41-45 days from the first dose). Subsequent samples collected at 69-75 days, 130-135 days, and 221-229 days after the first vaccination showed positive responses but a biphasic decline in the levels of anti-SARS-CoV-2 antibodies. CONCLUSIONS Declining antibody levels in these participants support the use of booster vaccination to increase antibody levels 4-6 months after the initial vaccine series and continued monitoring to assess the durability of COVID-19 vaccine responses. These results are in agreement with other studies showing antibody persistence but declining the antibody levels in the months after immunization with mRNA-based vaccines. The seroconversion panels described here could be useful in the development of antibody assays and in the assessment of the duration of antibody responses to vaccine boosters compared to the initial vaccine series. This panel could also be used to assess antibody activity against emerging viral variants (eg B.1.1.529 [Omicron] and its subvariants) compared to earlier variants.
Loss of function of ENT3 drives histiocytosis and inflammation through TLR-MAPK signaling
Authors: Shiloh Ruth , Lubin Ruth , David Odeya , Geron Ifat , Okon Elimelech , Hazan Idit , Zaliova Marketa , Amarilyo Gil , Birger Yehudit , Borovitz Yael , Brik Dafna , Broides Arnon , Cohen-Kedar Sarit , Harel Liora , Kristal Eyal , Kozlova Daria , Ling Galina , Shapira Rootman Mika , Shefer Averbuch Noa , Spielman Shiri , Trka Jan , Izraeli Shai , Yona Simon , Elitzur Sarah 
Published: September 2023

Abstract
Histiocytoses are inflammatory myeloid neoplasms often driven by somatic activating mutations in mitogen-activated protein kinase (MAPK) cascade genes. H syndrome is an inflammatory genetic disorder caused by germ line loss-of-function mutations in SLC29A3, encoding the lysosomal equilibrative nucleoside transporter 3 (ENT3). Patients with H syndrome are predisposed to develop histiocytosis, yet the mechanism is unclear. Here, through phenotypic, molecular, and functional analysis of primary cells from a cohort of patients with H syndrome, we reveal the molecular pathway leading to histiocytosis and inflammation in this genetic disorder. We show that loss of function of ENT3 activates nucleoside-sensing toll-like receptors (TLR) and downstream MAPK signaling, inducing cytokine secretion and inflammation. Importantly, MEK inhibitor therapy led to resolution of histiocytosis and inflammation in a patient with H syndrome. These results demonstrate a yet-unrecognized link between a defect in a lysosomal transporter and pathological activation of MAPK signaling, establishing a novel pathway leading to histiocytosis and inflammation.
Complementary HLH susceptibility factors converge on CD8 T-cell hyperactivation
Authors: Landy Emily , Varghese Jemy , Dang Vinh , Szymczak-Workman Andrea , Kane Lawrence P. , Canna Scott W. 
Published: September 2023

Abstract
Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening hyperinflammatory syndromes. Familial HLH is caused by genetic impairment of granule-mediated cytotoxicity (eg, perforin deficiency). MAS is linked to excess activity of the inflammasome-activated cytokine interleukin-18 (IL-18). Though individually tolerated, mice with dual susceptibility (Prf1⁻/⁻Il18tg; DS) succumb to spontaneous, lethal hyperinflammation. We hypothesized that understanding how these susceptibility factors synergize would uncover key pathomechanisms in the activation, function, and persistence of hyperactivated CD8 T cells. In IL-18 transgenic (Il18tg) mice, IL-18 effects on CD8 T cells drove MAS after a viral (lymphocytic choriomeningitis virus), but not innate (toll like receptor 9), trigger. In vitro, CD8 T cells also required T-cell receptor (TCR) stimulation to fully respond to IL-18. IL-18 induced but perforin deficiency impaired immunoregulatory restimulation-induced cell death (RICD). Paralleling hyperinflammation, DS mice displayed massive postthymic oligoclonal CD8 T-cell hyperactivation in their spleens, livers, and bone marrow as early as 3 weeks. These cells increased proliferation and interferon gamma production, which contrasted with increased expression of receptors and transcription factors associated with exhaustion. Broad-spectrum antibiotics and antiretrovirals failed to ameliorate the disease. Attempting to genetically “fix” TCR antigen-specificity instead demonstrated the persistence of spontaneous HLH and hyperactivation, chiefly on T cells that had evaded TCR fixation. Thus, drivers of HLH may preferentially act on CD8 T cells: IL-18 amplifies activation and demand for RICD, whereas perforin supplies critical immunoregulation. Together, these factors promote a terminal CD8 T-cell activation state, combining features of exhaustion and effector function. Therefore, susceptibility to hyperinflammation may converge on a unique, unrelenting, and antigen-dependent state of CD8 T-cell hyperactivation.
Designing and development of multi-epitope chimeric vaccine against Helicobacter pylori by exploring its entire immunogenic epitopes: an immunoinformatic approach
Authors: Keshri Anand K. , Kaur Rimanpreet , Rawat Suraj S. , Arora Naina , Pandey Rajan K. , Kumbhar Bajarang V. , Mishra Amit , Tripathi Shweta , Prasad Amit 
Published: September 2023

Abstract
Background
Helicobacter pylori is a prominent causative agent of gastric ulceration, gastric adenocarcinoma and gastric lymphoma and have been categorised as a group 1 carcinogen by WHO. The treatment of H. pylori with proton pump inhibitors and antibiotics is effective but also leads to increased antibiotic resistance, patient dissatisfaction, and chances of reinfection. Therefore, an effective vaccine remains the most suitable prophylactic option for mass administration against this infection.

Results
We modelled a multi-chimera subunit vaccine candidate against H. pylori by screening its secretory/outer membrane proteins. We identified B-cell, MHC-II and IFN-γ-inducing epitopes within these proteins. The population coverage, antigenicity, physiochemical properties and secondary structure were evaluated using different in-silico tools, which showed it can be a good and effective vaccine candidate. The 3-D construct was predicted, refined, validated and docked with TLRs. Finally, we performed the molecular docking/simulation and immune simulation studies to validate the stability of interaction and in-silico cloned the epitope sequences into a pET28b(+) plasmid vector.

Conclusion
The multiepitope-constructed vaccine contains T- cells, B-cells along with IFN-γ inducing epitopes that have the property to generate good cell-mediated immunity and humoral response. This vaccine can protect most of the world’s population. The docking study and immune simulation revealed a good binding with TLRs and cell-mediated and humoral immune responses, respectively. Overall, we attempted to design a multiepitope vaccine and expect this vaccine will show an encouraging result against H. pylori infection in in-vivo use.
Meta-analysis of transcriptome reveals key genes relating to oil quality in olive
Authors: Asadi AliAkbar , Shariati Vahid , Mousavi Soraya , Mariotti Roberto , Hosseini Mazinani Mehdi 
Published: September 2023

Abstract
Background
Olive oil contains monounsaturated oleic acid up to 83% and phenolic compounds, making it an excellent source of fat. Due to its economic importance, the quantity and quality of olive oil should be improved in parallel with international standards. In this study, we analyzed the raw RNA-seq data with a meta-analysis approach to identify important genes and their metabolic pathways involved in olive oil quality.

Results
A deep search of RNA-seq published data shed light on thirty-nine experiments associated with the olive transcriptome, four of these proved to be ideal for meta-analysis. Meta-analysis confirmed the genes identified in previous studies and released new genes, which were not identified before. According to the IDR index, the meta-analysis had good power to identify new differentially expressed genes. The key genes were investigated in the metabolic pathways and were grouped into four classes based on the biosynthetic cycle of fatty acids and factors that affect oil quality. Galactose metabolism, glycolysis pathway, pyruvate metabolism, fatty acid biosynthesis, glycerolipid metabolism, and terpenoid backbone biosynthesis were the main pathways in olive oil quality. In galactose metabolism, raffinose is a suitable source of carbon along with other available sources for carbon in fruit development. The results showed that the biosynthesis of acetyl-CoA in glycolysis and pyruvate metabolism is a stable pathway to begin the biosynthesis of fatty acids. Key genes in oleic acid production as an indicator of oil quality and critical genes that played an important role in production of triacylglycerols were identified in different developmental stages. In the minor compound, the terpenoid backbone biosynthesis was investigated and important enzymes were identified as an interconnected network that produces important precursors for the synthesis of a monoterpene, diterpene, triterpene, tetraterpene, and sesquiterpene biosynthesis.

Conclusions
The results of the current investigation can produce functional data related to the quality of olive oil and would be a useful step in reducing the time of cultivar screening by developing gene specific markers in olive breeding programs, releasing also new genes that could be applied in the genome editing approach.