bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantum dynamics of a driven parametric oscillator in a Kerr medium
Authors: Bolandhemmat E. , Kheirandish F. 
Published: January 2023

Abstract
In this paper, we first analyze a parametric oscillator with both mass and frequency time-dependent. We show that the evolution operator can be obtained from the evolution operator of another parametric oscillator with a constant mass and time-dependent frequency followed by a time transformation $t\rightarrow\int_0^t dt'\,1/m(t')$. Then we proceed by investigating the quantum dynamics of a parametric oscillator with unit mass and time-dependent frequency in a Kerr medium under the influence of a time-dependent force along the motion of the oscillator. The quantum dynamics of the time-dependent oscillator is analyzed from both analytical and numerical points of view in two main regimes: (i) small Kerr parameter $\chi$, and (ii) small confinement parameter $k$. In the following, to investigate the characteristics and statistical properties of the generated states, we calculate the autocorrelation function and the Mandel $Q$ parameter, and to more elaborate, we obtain the (quasi) probability distributions on phase space like Glauber-Sudarshan $P$-function and Husimi distribution as the nonclassicality criteria.
­­­MORC2 interaction with MAX contributes to the expression of Glycolytic enzymes,
Breast Cancer Cell Proliferation and Migration
Authors: Guddeti Rohith Kumar , Pacharla Himavani , Yellapu Nanda Kumar , Karyala Prashanthi , Pakala Suresh 
Published: January 2023

Abstract
Cancer cell proliferation is a high energy demanding process, where the cancer cells acquire the energy by high rates of glycolysis, and this phenomenon is known as the “Warburg effect”. Microrchidia 2 (MORC2), an emerging chromatin remodeler, is over expressed in several cancers including breast cancer, and found to promote cancer cell proliferation. However, the role of MORC2 in glucose metabolism in cancer cells remains unexplored. In this study, we report that MORC2 interacts indirectly with the genes involved in glucose metabolism via transcription factors MAX (MYC-associated factor X) and MYC. We also found that MORC2 colocalizes and interacts with MAX. Further, we observed a positive correlation of expression of MORC2 with glycolytic enzymes Hexokinase 1 (HK1), Lactate dehydrogenase A (LDHA) and Phosphofructokinase platelet type (PFKP) in multiple cancers. Surprisingly, the knockdown of either MORC2 or MAX not only decreased the expression of glycolytic enzymes but also inhibited breast cancer cell proliferation and migration. Together, these results demonstrate the involvement of the MORC2/MAX signaling axis in the expression of glycolytic enzymes and breast cancer cell proliferation and migration.
Development and feasibility of an oral health E-learning program for long-term Japanese overseas workers: A pilot randomized controlled trial
Authors: Sasayama Kiriko , Momoi Yasuko , Gilmour Stuart , Ota Erika 
Published: January 2023

Abstract
Background

This study aimed to assess the feasibility and acceptability of an oral health self-care e-learning intervention for overseas workers as well as the research procedures for a future controlled trial.

Methods

We randomly allocated participants to either the intervention (n = 47) or control (n = 51) group. The intervention group received a standardized leaflet plus a theory-based oral health e-learning program. The control group received only the standardized leaflet. We assessed health behaviour related to fluoride toothpaste use, knowledge, motivation, oral care self-efficacy, and oral health QOL. Chi-square and t test analyses were performed to make comparisons between the two groups. To adjust for the common effects observed in both groups, regression models were constructed using a difference-in-differences framework. To evaluate the research process, participants in the intervention group were asked open-ended questions, and themes relating to the acceptability of this program and how the research procedures and processes worked in practice were identified.

Results

A total of 82 participants were included in the analysis. There was a statistically significant improvement in some fluoride use behaviours (Intervention = 22, Control = 10; P < .001) and knowledge in the intervention group (Intervention = 72.69, Control = 57.97; P < .001). Of the 36 respondents in the intervention group, 27 (70.4%) said that the e-learning intervention had changed their behaviour.

Conclusion

The oral health self-care e-learning intervention had a favourable effect only on fluoride-use behaviour and knowledge. Next, this feasible and acceptable pilot study should be used with an appropriate sample size in a randomized controlled trial.
Trial registration
The trial protocol was registered with UMIN-CTR (ID: UMIN000045883) on 27/10/2021.
TNFRSF12A is associated with immune cell infiltration in thyroid carcinoma
Authors: Zheng Xiao-Feng , Tu Zhuo-Te 
Published: January 2023

Abstract
Objective: Comprehensively investigated the immune infiltration of thyroid cancer, to explore key immune-related genes and potential molecular mechanisms for thyroid carcinoma through bioinformatics analysis.
Methods: The thyroid carcinoma (THCA) expression profiles came from the Cancer Genome Atlas (TCGA) databases. The differences in the infiltration levels of immune cells between THCA were analyzed by the CIBERSORT. We analyzed the differentially expressed genes (DEGs) in thyroid, downloaded the immunologically relevant list of genes from IMMPORT, and then selected the differentially expressed immune genes. Gene ontology (GO) terms and pathways associated with these DEGs were identified, and protein–protein interactions (PPIs) were analyzed. The expression of TNFRSF12Ain THCA was analyzed in the cBioPortal database. Additionally, we used the Tumor Immune Estimation Resource (TIMER) database evaluated correlation between TNFRSF12A expression and immune cell infiltration.Finally, Kaplan-Meier survival analysis was presented to predict the survival times between high and low TNFRSF12A expression groups for THCA.
Results: Differentially expressed immune genes associated with prognosis included BMP2, SEMA6B, INHBB and TNFRSF12A. There were distinct differences in the infiltration levels of immune cells between THCA and normal tissues. TNFRSF12A was identified to be highly expressed in THCA compared to normal tissues. TNFRSF12A mutation occurred in 5% of THCA samples, and low mRNA expression was the most common type of mutation. TNFRSF12A expression was significantly correlated to the infiltration levels of B cells, CD8+ T cells, CD4+ T cells, neutrophils and dendritic cells. Gene Set Enrichment Analysis (GSEA) results indicated that TNFRSF12A could be involved in key biological processes and pathways of cytokine-cytokine receptor interaction. Patients with low TNFRSF12A expression usually experienced shorten overall survival time than those with its high expression.
Conclusion: Our findings revealed that TNFRSF12A was significantly related to immune cell infiltration, which may provide potential value for immunotherapy.
Application of a Cost Calculation Approach in Medical Oncology: Case of Hassan Ii University Hospital in Morocco
Authors: Benabdallah Anasse , JELLOULI Tarik 
Published: January 2023

Abstract
Background: Text for this section. In Morocco, hospitals do not have cost accounting systems that allow them to produce reliable budget forecasts and to know and justify the costs of their operations. Moroccan hospitals are thus among the public organizations that do not know the cost of their services.
Faced with the lack of data on the cost of care for cancer patients, this research aims to implement an approach to calculate the cost of services provided at the level of the medical oncology department of the Hassan II University Hospital in Fez. The objective is to provide data that can be used in the pricing and financing process of the different services provided in medical oncology.
Methods: In this research work, we opted for a qualitative approach through a case study. Two main qualitative data collection tools were used: observation and document analysis. We used mainly Microsoft World for text entry and Excel for data processing to determine costs and related statistics
Results: The result of this study shows the possible application of an approach that follows a traditional approach of cost calculation. Two main methods were mainly used, namely the volume-based allocation method and the RVU method.
Revealing the intrinsic electronic-level principle driving metal-support interaction trends of single-atom Ru with oxides through cooperative orbital coupling
Authors: Xiang Guolei , Zhou Jun , Guo Qianli , Li Yangyang , Zhang Guikai , Chu Sheng-Qi , Zheng Lei , Zheng Lirong , Liang Xin , Huang Weixin 
Published: January 2023

Abstract
Supports dominate chemical states and catalytic performances of single-atom catalysts (SACs); however, electronic-scale physicochemical principles intrinsically driving SAC-support interactions and their structure-function relationships are still not coherently clarified nor unified yet. Using atomically-supported Ru on rutile-type oxides MO2 (TiO2, SnO2, and MnO2) for CO adsorption and oxidation as model systems, here we explore the interaction trends and electronic-level origins of SAC-support interactions. Our results show that the reactivity of surface oxygen atoms overall controls the strengths of Ru1-MO2 binding and CO-Ru1 adsorption, and catalytic activity of CO oxidation. Through combining experimental probing and theoretical calculations, we reveal that these interaction trends can be coherently unified by an electronic-level interaction mode through competitive orbital coupling in CO-Ru1-O5-MO2 systems, in which neighboring bonds are competitive while non-neighboring bonds are cooperative in coupling strength. The interaction mode of orbitals provides new insights for understanding SAC-support interactions and rational design of SACs.
Are Width, Length, Depth and Area of Submucosal Invasion Predictive for Lymph Nodes Metastasis in pT1 Colorectal Cancer?
Authors: Maynovskaia Olga , Rybakov Evgeny , Chernyshov Stanislav , Khomyakov Evgeniy , Achkasov Sergey 
Published: January 2023

Abstract
Background and study aim: Colorectal carcinomas limited by submucosa (pT1) remain the challenge in terms of choice for treatment options from local excision to radical surgery. The aim of the study was to evaluate morphometric and morphologic risk factors of regional lymph nodes metastasis (LNM) for pT1 colorectal carcinoma (CRC).
Patients and methods: The histology of patients undergoing oncological resection from 2016 to 2022 was reviewed. Tumor grade (G), budding (Bd), poorly differentiated clusters (PDC), cancer gland rupture (CGR), lymphovascular invasion (LVI) and deep submucosal invasion (DSI) as well as width, length, total area and deep submucosal invasion (DSI) were evaluated as risk factors of LNM.
Results: Two hundred and sixty-four cases of colon and rectal carcinomas with invasion into the submucosal layer (pT1) were identified. Of them LNM was found in 46/264 (17.4%) cases. All morphometric parameters and DSI (p=0.33) failed to demonstrate association with LNM. High grade (G3) (p=0.05), Bd (p=0.056) and PDC (p<0.0001) were associated with LNM. In multivariate analysis LVI+ remains the only significant independent risk factor [OR 15.7; 95% CI 8.5 - 94.9] (p<0.0001).
Conclusion: The DSI invasion of T1 CRC as well as other morphometric parameters of submucosal tumor spread do not have any predictive value in terms of LNM. Poor differentiation of colorectal carcinoma, tumor budding (Bd), poorly differentiated clusters (PDC) and lymphovascular invasion (LVI) are the significant risk factors for LNM in T1 CRC. Among them LVI was the only independent risk factor.
Unique Transcriptional Signatures Correlate with Behavioral and Psychological Symptom Domains in Alzheimer’s Disease
Authors: Dong Hongxin , Fisher Daniel , Dunn Jeffrey , Keszycki Rachel , Rodriguez Guadalupe , Bennett David , Wilson Robert 
Published: January 2023

Abstract
Despite the significant burden, cost, and worse prognosis of Alzheimer’s Disease (AD) with Behavioral and Psychological Symptoms of Dementia (BPSD), little is known about the molecular causes of these symptoms. Using antemortem assessments of BPSD in AD, we demonstrate that individual BPSD can be grouped into 4 domain factors in our sample: Affective, Apathy, Agitation, and Psychosis. Then, we performed a transcriptome-wide analysis for each domain utilizing bulk RNA-seq of post-mortem Anterior Cingulate Cortex (ACC) tissue. Though all 4 domains are associated with a predominantly downregulated pattern of hundreds of
DEGs, most DEGs are unique to each domain, with only 22 DEGs being common to all BPSD domains, including TIMP1. Weighted Gene Co-Expression Network Analysis (WGCNA) yielded multiple transcriptional modules that were shared between BPSD domains or unique to each domain, and NetDecoder was used to analyze context-dependent information flow through the biological network. For the agitation domain, we found that all DEGs and a highly correlated transcriptional module were functionally enriched for ECM-related genes including TIMP1, TAGLN, and FLNA. Another unique transcriptional module also associated with the agitation domain was enriched with genes involved in post-synaptic signaling, including DRD1, PDE1B, CAMK4, and GABRA4. By comparing context-dependent changes in DEGs between cases and control networks, ESR1 and PARK2 were implicated as two high impact genes associated with agitation that mediated significant information flow through the biological network. Overall, our work establishes unique targets for future study of the biological mechanisms of BPSD and resultant drug development.
Novel β-synuclein Rearrangements in tumor
Authors: Xiao Peifang , Chen Nan , Shao Tingting , Bian Xinni , Miao Jie , Zheng Jiajia , Lang Xingping , Wang Yiting , Chen Xiaojun , Jin Liqin , Hu Shaoyan , Xiao Sheng 
Published: January 2023

Abstract
Purpose
The synuclein family includes a-, b-, g-synuclein and is predominantly expressed in neurons. a- and b-synuclein is mutated in Parkinson's disease and dementia with Lewy bodies. Recent studies found up-regulation of the synucleins in several tumors including breast cancer, ovarian cancer, meningioma, and melanoma, and the high level of synuclein was associated with poor prognosis and drug resistance. We describe here a novel intragenic rearrangement of b-synuclein in pediatric T-cell acute lymphoblastic leukemia (T-ALL). An additional case of b-synuclein rearrangement was found in a squamous cell carcinoma of the lung by searching the public TCGA database.
Methods
Morphological evaluation and immunohistochemistry were used for diagnostic purposes. Karyotype analysis, targeted RNA NGS, FISH, and RT-PCR were used to identify the fusion transcript.
Results
A pediatric T-ALL carried a translocation of chromosomes 5 and 12, resulting in an in-frame fusion between the b-synuclein (SNCB) and the ETS variant transcription factor 6 (ETV6), a gene frequently rearranged in acute myeloid leukemia (AML), B-ALL, and T-ALL. Another SNCB rearrangement involved low-density lipoprotein receptor class A domain containing 3 (LDLRAD3) in a lung carcinoma. Both fusions retained the c-terminal of b-synuclein, a region important for protein interaction.
Conclusion
We describe the first cases of b-synuclein rearrangement in tumors. Since b-synuclein shares extensive similarity in amino acid sequences with a-synuclein and the a-synuclein binds to 14-3-3, an important regulator of apoptosis, we suspect that the rearranged b-synuclein likely contributes to tumorigenesis by deregulating apoptosis. In addition, the rearranged b-synuclein could deregulate the cell cycle, because overexpression of b-synuclein leads to increased cell proliferation.
Heterojunction structure for high electrical performance of Cu/Sn-LaPO 4 /n-Si type Schottky barrier diode
Authors: Mariappan R. , Priya R. , Bakkiyaraj R. , Karthikeyan A. 
Published: January 2023

Abstract
The Cu/Sn-LaPO4/n-Si MIS Schottky barrier diode (SBD) with a 10% Sn doping has been successfully fabricated, and their photodiode properties were investigated. The I-V forward and reverse bias curves determine the photodiode parameters such as barrier height, ideality factor, and saturation currents from the thermionic emission theory. The results of the experiments with 10% Sn-LaPO4 SBDs showed a linear decrease in the ideality factor (n) up to 2.31 and 1.74, respectively, with a small increase in the effective barrier height (𝛟B) of 0.744 and 0.806 eV in dark and light conditions these results signify their use in optoelectronic industries.
Motor-evoked potential monitoring from urinary sphincter muscle during pediatric lumbosacral spine surgery: A case series
Authors: Ogawa Yuki , Hayashi Hironobu , Sasaki Ryota , Takatani Tsunenori , Oi Ayako , Uemura Keiko , Kawaguchi Masahiko 
Published: January 2023

Abstract
Purpose
Postoperative urinary dysfunction following lumbosacral spine surgery is devastating. To assess urinary function, we invented a pediatric urinary catheter equipped with electrodes for the direct transurethral recording of myogenic potential from the external urethral sphincter (EUS). This paper presents two cases in which urinary function was monitored intraoperatively by recording of motor-evoked potential (MEP) from EUS during lumbosacral spine surgery in children.
Methods
Two children (aged 2 and 6 years) were included in this study. One patient had no preoperative neurological dysfunction, while the other had frequent urination and urinary incontinence. A pair of surface electrodes was attached to a silicone rubber urethral catheter (6 or 8 Fr; diameter, 2 or 2.6 mm). The MEP from the EUS were recorded to assess the function of the centrifugal tract from the motor cortex to the pudendal nerve.
Results
Baseline MEP waveforms from the EUS were successfully recorded with latency and amplitude of 39.5 ms and 66 µV in patient 1 and 39.0 ms and 113 µV in patient 2, respectively. A significant decrease in amplitude was not observed during surgery in the two cases. No new urinary dysfunction and complications associated with the urinary catheter-equipped electrodes developed postoperatively.
Conclusion
Using an electrode-equipped urinary catheter, monitoring of MEP from the EUS could be applicable during lumbosacral surgery in pediatric patients.
Rectal infarction caused by transcatheter arterial embolization of the superior rectal artery below the Sudeck's point: A case report
Authors: Wang Rongdi , Yin Yefeng , Guo Xu , Xu Meng 
Published: January 2023

Abstract
BACKGROUND
Transcatheter arterial embolization (TAE) is the first-line treatment for lower gastrointestinal bleeding. Previous reports have examined the safety and efficacy of TAE, but few studies have assessed its complications. Some studies have only statistically analyzed complication incidence, but it is relatively plain to discuss the causes. Here we emphasize the Sudeck's point as watershed areas for colonic blood supply. Especially for those rare cases which are lack of anastomosis between the sigmoid artery and the superior rectal artery, that should be taken into serious consideration by both surgeons and interventionists.
CASE SUMMARY
In this case, the patient was diagnosed with malignant rectal tumor bleeding. Because the tumor blocked the intestinal lumen, the endoscope could not reach the bleeding site. Therefore, Transcatheter arterial embolization was selected as a hemostatic measure. The superior rectal artery below the Sudeck's point was utilized as the embolization site. Spring coil and Gelfoam were used as embolization materials. However, laparoscopic exploration revealed ischemic necrosis of the upper rectum 25 h later. Due to the lack of blood transport, bowel anastomosis could not be completed after tumor resection, and a sigmoid colostomy was required.
CONCLUSION
When transcatheter arterial embolization serves as an adjunctive therapy, it aims to reduce arterial perfusion pressure rather than to completely occlude the blood vessel. The choice of embolization materials and location is extremely important.
Efficacy of cataract surgeries performed during blindness prevention programs in Chongqing, China: A multicenter prospective study
Authors: Xiang Yongguo , Wang Xiaoqin , Cao Xiaochuan , Wei Fang , Chen Yu , Ran Jianchuan , Long Zhengqin , Tan Qunwu , Lai Zhenying , Liu Li , Zhao Desheng , Xiong Liang , Tang Bin , Wan Wenjuan , Hu Ke 
Published: January 2023

Abstract
Objective
To determine the efficacy of cataract surgeries in blindness prevention programs in Chongqing.
Methods
During February–December 2019, we prospectively enrolled 487 patients (592 eyes) undergoing cataract surgery during blindness prevention programs in 6 Chongqing district/county hospitals (experimental group) and 481 patients (609 eyes) undergoing cataract surgery in the First Affiliated Hospital of Chongqing Medical University (controls). Uncorrected visual acuity (UCVA), refractive status, best corrected visual acuity (BCVA), slit lamp examination, and visual function/quality of life (VF-QOL) questionnaire scores were evaluated preoperatively, and at 1 and 6 months postoperatively.
Results
In the experimental group, UCVA, BCVA, and VF-QOL scores at 1 and 6 months were better than the preoperative values (P < 0.05), but lower than the control-group values (P < 0.05). Rates of good UCVA and BCVA outcomes (≤ 0.5 logMAR) in the experimental group were 76.2% and 87.6%, respectively, at 1 month and 68.9% and 83.1%, respectively, at 6 months. Most eyes in the experimental (82.1%) and control (89.5%) groups had refractive errors within ± 1 D at 1 month. At 6 months, posterior capsule opacification (PCO) was more common in the experimental group (20.9% vs. 15.0%, P < 0.05). At 6 months, the main causes of visual impairment (UCVA > 0.5 logMAR) in the experimental group were uncorrected refractive errors (33.0%), PCO (29.5%), and fundus diseases (33.9%).
Conclusion
Cataract surgeries in blindness prevention programs in Chongqing significantly improved visual acuity, VF, and QOL, but underperformed compared to surgeries in the tertiary teaching hospital.
Study on time stability on reinforced soil slope by anchor under flood loading effect
Authors: Wang Jun , Nie Zhipeng , Liu Lin 
Published: January 2023

Abstract
In order to analyze the adverse effect of flood effect on slope stability, the analytical expressions of buoyancy force and capillary force, hydrodynamic pressure and impact force, and scour erosion were proposed based on the aging characteristics of soil shear strength and limit equilibrium theory. According to the load combination and flood action, shear failure occurs preferentially at the foot of slope. Then, the plastic zone continues to extend upward to produce traction landslide disaster mode. Furthermore, the power function relation between shear strength index and time was established. The nonlinear accelerated creep model was obtained. At the same time, the analytic formula of safety factor for flood loading effect slope aging stability, the time-varying characteristic value of anchor force and the compensation value of anchor force were also obtained. In addition, the numerical example shows that the slope safety factor decreases by more than 20% considering the effect of flood ascending scour and impact, and the compensation value of anchorage force increases obviously with time, and the change rate of compensation value of anchorage force increases nonlinearly with the increase of design safety factor.