bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delta-band neural envelope tracking predicts speech intelligibility in noise in preschoolers
Authors: Van Hirtum Tilde , Somers Ben , Verschueren Eline , Dieudonné Benjamin , Francart Tom 
Published: February 2023

ABSTRACTBehavioral tests are currently the gold standard in measuring speech intelligibility. However, these tests can be difficult to administer in young children due to factors such as motivation, linguistic knowledge and cognitive skills. It has been shown that measures of neural envelope tracking can be used to predict speech intelligibility and overcome these issues. However, its potential as an objective measure for speech intelligibility in noise remains to be investigated in preschool children. Here, we evaluated neural envelope tracking as a function of signal-to-noise ratio (SNR) in 14 5-year-old children. We examined EEG responses to natural, continuous speech presented at different SNRs ranging from -8 (very difficult) to 8 dB SNR (very easy). As expected delta band (0.5-4 Hz) tracking increased with increasing stimulus SNR. However, this increase was not strictly monotonic as neural tracking reached a plateau between 0 and 4 dB SNR, similarly to the behavioral speech intelligibility outcomes. These findings indicate that neural tracking in the delta band remains stable, as long as the acoustical degradation of the speech signal does not reflect significant changes in speech intelligibility. Theta band tracking (4-8 Hz), on the other hand, was found to be drastically reduced and more easily affected by noise in children, making it less reliable as a measure of speech intelligibility. By contrast, neural envelope tracking in the delta band was directly associated with behavioral measures of speech intelligibility. This suggests that neural envelope tracking in the delta band is a valuable tool for evaluating speech-in-noise intelligibility in preschoolers, highlighting its potential as an objective measure of speech in difficult-to-test populations.
The Future of the United States Overdose Crisis: Challenges and Opportunities
Authors: CERDÁ MAGDALENA , KRAWCZYK NOA , KEYES KATHERINE 
Published: February 2023

Policy Points
People are dying at record numbers from overdose in the United States.
Concerted action has led to a number of successes, including reduced inappropriate opioid prescribing and increased availability of opioid use disorder treatment and harm‐reduction efforts, yet ongoing challenges include criminalization of drug use and regulatory and stigma barriers to expansion of treatment and harm‐reduction services.
Priorities for action include investing in evidence‐based and compassionate policies and programs that address sources of opioid demand, decriminalizing drug use and drug paraphernalia, enacting policies to make medication for opioid use disorder more accessible, and promoting drug checking and safe drug supply.
Circ_0001667 accelerates breast cancer proliferation and angiogenesis through regulating CXCL10 expression by sponging miR‐6838‐5p
Authors: Zhang Xu , Huang Jiami , Wang Jiayun , Li Yongheng , Hu Guohua , Li He 
Published: February 2023

AbstractBackgroundAn increasing number of circular RNAs (circRNAs) have been shown to play an important role in the tumorigenesis of breast cancer. The aim of this study was to investigate the expression and function of circ_0001667 and its potential molecular mechanisms in breast cancer.MethodsThe expression levels of circ_0001667, miR‐6838‐5p and CXC chemokine ligand 10 (CXCL10) in breast cancer tissues and cells were detected by quantitative real‐time PCR. Cell counting kit‐8 assay, EdU assay, flow cytometry, colony formation and tube formation assays were used to detect cell proliferation and angiogenesis. The binding relationship between miR‐6838‐5p and circ_0001667 or CXCL10 was predicted using the starBase3.0 database and verified by dual‐luciferase reporter gene assay, RIP and RNA pulldown. Animal experiments were performed to assess the function of circ_0001667 knockdown on breast cancer tumor growth.ResultsCirc_0001667 was highly expressed in breast cancer tissues and cells, and its knockdown inhibited proliferation and angiogenesis of breast cancer cells. Circ_0001667 sponged miR‐6838‐5p, and inhibition of miR‐6838‐5p reversed the inhibitory effect of silencing circ_0001667 on proliferation and angiogenesis of breast cancer cells. MiR‐6838‐5p targeted CXCL10, and overexpression of CXCL10 reverses the effect of miR‐6838‐5p overexpression on breast cancer cell proliferation and angiogenesis. In addition, circ_0001667 interference also reduced breast cancer tumor growth in vivo.ConclusionCirc_0001667 is involved in breast cancer cell proliferation and angiogenesis through regulation of the miR‐6838‐5p/CXCL10 axis.
Rate‐dependent effects of narrative interventions in a longitudinal study of individuals who use alcohol
Authors: Craft William H. , Dwyer Candice L. , Tomlinson Devin C. , Yeh Yu‐Hua , Tegge Allison N. , Bickel Warren K. 
Published: February 2023

AbstractBackgroundDelay discounting (DD), the decrease in reward valuation as a function of delay to receipt, is a key process undergirding alcohol use. Narrative interventions, including episodic future thinking (EFT), have decreased delay discounting and demand for alcohol. Rate dependence, the relationship between a baseline rate and change in that rate after an intervention, has been evidenced as a marker of efficacious substance use treatment, but whether narrative interventions have rate‐dependent effects needs to be better understood. We investigated the effects of narrative interventions on delay discounting and hypothetical demand for alcohol in this longitudinal, online study.MethodsIndividuals (n = 696) reporting high‐ or low‐risk alcohol use were recruited for a longitudinal 3‐week survey via Amazon Mechanical Turk. Delay discounting and alcohol demand breakpoint were assessed at baseline. Individuals returned at weeks 2 and 3 and were randomized into the EFT or scarcity narrative interventions and again completed the delay discounting tasks and alcohol breakpoint task. Oldham's correlation was used to explore the rate‐dependent effects of narrative interventions. Study attrition as a function of delay discounting was assessed.ResultsEpisodic future thinking significantly decreased, while scarcity significantly increased delay discounting relative to baseline. No effects of EFT or scarcity on the alcohol demand breakpoint were observed. Significant rate‐dependent effects were observed for both narrative intervention types. Higher delay discounting rates were associated with a greater likelihood of attrition from the study.ConclusionThe evidence of a rate‐dependent effect of EFT on delay discounting rates offers a more nuanced, mechanistic understanding of this novel therapeutic intervention and can allow more precise treatment targeting by demonstrating who is likely to receive the most benefit from it.
Validation of the quantification of phosphatidylethanol 16:0/18:1 concentrations in TASSO‐M20 devices
Authors: Jett Julianne D. , Beck Rachael , Tyutyunnyk Diana , Sanchez Jesus , Lopez‐Cruzan Marisa , Ginsburg Brett C. , McPherson Sterling M. , Javors Martin A. , McDonell Michael G. , Hill‐Kapturczak Nathalie 
Published: February 2023

AbstractBackgroundPhosphatidylethanol 16:0/18:1 (PEth), found in whole blood, is a biomarker for alcohol consumption with high sensitivity, specificity, and a long detection window. The TASSO‐M20 device is used to self‐collect capillary blood from the upper arm and has advantages over finger stick methods. The purpose of this study was to (1) validate PEth measurement using the TASSO‐M20 device, (2) describe the TASSO‐M20 for blood self‐collection during a virtual intervention, and (3) characterize PEth, urinary ethyl glucuronide (uEtG) and self‐reported alcohol in a single participant over time.MethodsPEth levels in blood samples dried on TASSO‐M20 plugs were compared to those in (1) liquid whole blood (N = 14) and (2) dried blood spot cards (DBS; N = 23). Additionally, the self‐reported drinking, positive or negative uEtG results (dip card cutoff ≥300 ng/mL), and observed self‐collection of blood with TASSO‐M20 devices for PEth levels were obtained over time during virtual interviews of a single contingency management participant. High‐performance liquid chromatography with tandem mass spectrometry detection was used to measure PEth levels for both preparations.ResultsPEth concentrations from dried blood on TASSO‐M20 plugs and liquid whole blood were correlated (0 to 1700 ng/mL; N = 14; r2 = 0.988; slope = 0.951) and in a subgroup of samples with lower concentrations (N = 7; 0 to 200 ng/mL; r2 = 0.944, slope = 0.816). PEth concentrations from dried blood on TASSO‐M20 plugs and DBS were correlated (0 to 2200 ng/mL; N = 23; r2 = 0.927; slope = 0.667) and in a subgroup of samples with lower concentrations (N = 16; 0 to 180 ng/mL; r2 = 0.978, slope = 0.749). Results of the contingency management participant indicate that changes in PEth levels (TASSO‐M20) and uEtG concentrations were consistent with each other and with changes in self‐reported alcohol use.ConclusionsOur data support the utility, accuracy, and feasibility of using the TASSO‐M20 device for blood self‐collection during a virtual study. The TASSO‐M20 device had multiple advantages over the typical finger stick method, including consistent blood collection, participant acceptability, and less discomfort as indicated by acceptability interviews.
A review of JAK and IL‐23 inhibitors to treat vitiligo
Authors: Lee Henry , Cowan Timothy L. , Daniel Benjamin S. , Murrell Dédée F. 
Published: February 2023

AbstractVitiligo is an autoimmune skin disorder resulting in the depigmentation of skin characterised by patches of varying sizes and shapes. A common disorder of pigmentation that affects 0.5%–2% of the global population. Despite its well‐understood autoimmune pathogenesis, the targets for effective cytokine intervention remain unclear. Current first‐line treatments include oral or topical corticosteroids, calcineurin inhibitors and phototherapy. These treatments are limited, have varying efficacies, and are associated with significant adverse events or can be time‐consuming. Therefore, biologics should be explored as a potential treatment for vitiligo. There are currently limited data for the use of JAK and IL‐23 inhibitors for vitiligo. A total of 25 studies were identified in the review. There is promising evidence regarding the use of JAK and IL‐23 inhibitors for the treatment of vitiligo.
Accessto dental insurance and oral health inequities in the United States
Authors: Borrell Luisa N. , Reynolds Julie C. , Fleming Eleanor , Shah Parth D. 
Published: February 2023

AbstractWhile the oral health status of the United States (U.S.) population has improved over the years, racial/ethnic inequities are pervasive with Black Americans carrying a greater burden of oral diseases in most measured outcomes. Access to dental care is a major structural and societal determinant of oral health inequities rooted in structural racism. From post‐Civil War‐era to present day, this essay presents a series of examples of racist policies that have shaped access to dental insurance for Black Americans both directly and indirectly. Additionally, this essay explains the unique challenges of Medicare and Medicaid highlighting the specific disparities that these public insurance programs face, and proposes policy recommendations aimed to reduce racial/ethnic inequities in dental coverage and access to advance the nation's oral health with comprehensive dental benefits in public insurance programs.
Achieving conservation and restoration outcomes through ecologically beneficial aquaculture
Authors: Overton Kathy , Dempster Tim , Swearer Stephen E. , Morris Rebecca L. , Barrett Luke T. 
Published: February 2023

AbstractA range of conservation and restoration tools are needed to safeguard the structure and function of aquatic ecosystems. Aquaculture, the culturing of aquatic organisms, often contributes to the numerous stressors that aquatic ecosystems face, yet some aquaculture activities can also deliver ecological benefits. We reviewed the literature on aquaculture activities that may contribute to conservation and restoration outcomes, either by enhancing the persistence or recovery of one or more target species or by moving aquatic ecosystems toward a target state. We identified 12 ecologically beneficial outcomes achievable via aquaculture: species recovery, habitat restoration, habitat rehabilitation, habitat protection, bioremediation, assisted evolution, climate change mitigation, wild harvest replacement, coastal defense, removal of overabundant species, biological control, and ex situ conservation. This list may be expanded as new applications are discovered. Positive intentions do not guarantee positive ecological outcomes, so it is critical that potentially ecologically beneficial aquaculture activities be evaluated via clear and measurable indicators of success to reduce potential abuse by greenwashing. Unanimity on outcomes, indicators, and related terminology will bring the field of aquaculture–environment interactions into line with consensus standards in conservation and restoration ecology. Broad consensus will also aid the development of future certification schemes for ecologically beneficial aquaculture.
Association between residual islet beta‐cell function and achieving the target of time in range in inpatients with type 2 diabetes undergoing antidiabetic treatment: An observation study
Authors: Xia Zhang , You Wenjun , Li Yuhao , Li Feng , Hao Shuai , Sun Yihan , Li Na , Lin Lu , Dou Jingtao , Su Xin , Zhai Qi , Zuo Yingting , Zhang Yibo , Gaisano Herbert Y. , Zheng Deqiang , He Yan , Jiang Jiajia 
Published: February 2023

AbstractAimTo assess whether the beta‐cell function of inpatients undergoing antidiabetic treatment influences achieving time in range (TIR) and time above range (TAR) targets.Materials and MethodsThis cross‐sectional study included 180 inpatients with type 2 diabetes. TIR and TAR were assessed by a continuous glucose monitoring system, with target achievement defined as TIR more than 70% and TAR less than 25%. Beta‐cell function was assessed by the insulin secretion‐sensitivity index‐2 (ISSI2).ResultsFollowing antidiabetic treatment, logistic regression analysis showed that lower ISSI2 was associated with a decreased number of inpatients achieving TIR (OR = 3.10, 95% CI: 1.19‐8.06) and TAR (OR = 3.40, 95% CI: 1.35‐8.55) targets after adjusting for potential confounders. Similar associations still existed in those participants treated with insulin secretagogues (TIR: OR = 2.91, 95% CI: 0.90‐9.36, P = .07; TAR, OR = 3.14, 95% CI: 1.01‐9.80) or adequate insulin therapy (TIR: OR = 2.84, 95% CI: 0.91‐8.81, P = .07; TAR, OR = 3.24, 95% CI: 1.08‐9.67). Furthermore, receiver operating characteristic curves showed that the diagnostic value of the ISSI2 for achieving TIR and TAR targets was 0.73 (95% CI: 0.66‐0.80) and 0.71 (95% CI: 0.63‐0.79), respectively.ConclusionsBeta‐cell function was associated with achieving TIR and TAR targets. Stimulating insulin secretion or exogenous insulin treatment could not overcome the disadvantage of lower beta‐cell function on glycaemic control.
Work–family conflict, educational involvement, and adolescent academic engagement duringCOVID‐19: An investigation of developmental differences
Authors: Wang Xinyi , Liu Sihan , Wu Xinchun , Ren Yizhen , Zou Shengqi 
Published: February 2023

AbstractObjectiveIn this research, we examine the mediating effect of educational involvement between parental work–family conflict and adolescent academic engagement during COVID‐19, as well as the differences among developmental stages.BackgroundOnline learning during the COVID‐19 lockdown created challenges for adolescent academic engagement. One of the toughest challenges was that parents experienced increased work–family conflict, making it difficult for them to be involved in adolescent education. In this context, it is essential to understand the impact of parental work–family conflict on adolescent academic engagement.MethodA total of 886 dual‐income families participated in the study. Mothers and fathers completed the questionnaire, including questions regarding work–family conflict and educational involvement. Adolescents completed an academic engagement scale.ResultsThe structural equation model in the total sample showed that parental educational involvement mediated the effect of maternal work–family conflict on adolescent academic engagement. In addition, paternal educational involvement mediated the effect of paternal work–family conflict on adolescent academic engagement. Multigroup analysis indicated the impact of work–family conflict only existed in middle and late adolescence, and mother played a more important role in late adolescence.ConclusionThe study results confirmed the mediating role of parental educational involvement between the relationship of paternal work–family conflict and adolescent academic engagement. Furthermore, this relationship may vary for families with an adolescent at different developmental stages.
A genome‐wide association study identified new variants associated with mathematical abilities in Chinese children
Authors: Zhang Liming , Wang Zhengjun , Zhu Zijian , Yang Qing , Cheng Chen , Zhao Shunan , Liu Chunyu , Zhao Jingjing 
Published: February 2023

AbstractMathematical ability is moderately heritable, and it is a complex trait which can be evaluated in several different categories. A few genetic studies have been published on general mathematical ability. However, no genetic study focused on specific mathematical ability categories. In this study, we separately performed genome‐wide association studies on 11 mathematical ability categories in 1146 students from Chinese elementary schools. We identified seven genome‐wide significant single nucleotide polymorphisms (SNPs) with strong linkage disequilibrium among each other (all r2 > 0.8) associated with mathematical reasoning ability (top SNP: rs34034296, p = 2.01 × 10−8, nearest gene: CUB and Sushi multiple domains 3, CSMD3). We replicated one SNP (rs133885) from 585 SNPs previously reported to be associated with general mathematical ability associated with division ability in our data (p = 1.053 × 10−5). In the gene‐ and gene‐set enrichment analysis by MAGMA, we found three significant enrichments of associations with three mathematical ability categories for three genes (LINGO2, OAS1 and HECTD1). We also observed four significant enrichments of associations with four mathematical ability categories for three gene sets. Our results suggest new candidate genetic loci for the genetics of mathematical ability.
Connected early‐career experiences of equality in academia during the pandemic and beyond: Our liminal journey
Authors: Scholz Frederike , Szulc Joanna Maria 
Published: February 2023

AbstractIn this paper, we draw on our subjective experiences as two female early‐career academics during the global COVID‐19 pandemic. While we acknowledge that the pandemic had negative implications for many female scholars due to compulsory telework or increased family responsibilities, we also want to shed light on the empowering experiences shaped by collegial support that became an important part of our pandemic story. We build on the theory of liminality to explain how the events triggered by the pandemic allowed us to break out of our uncomfortable occupational limbo (i.e., feeling “locked‐in” to the identity of a foreign‐born PhD graduate) and, through creating a kind of equality, resulted in some unique opportunities and challenges. During these difficult times, shaped by an increasing fear of us or our family catching COVID‐19, we embarked on a betwixt‐and‐between state that allowed us to grow as academics as a part of a collective.
Transvaginal mesh in Australia: An analysis of news media reporting from 1996 to 2021
Authors: Motamedi Mina , Carter Stacy M. , Degeling Chris 
Published: February 2023

AbstractIntroductionTransvaginal mesh (mesh) surgeries have been used to treat stress urinary incontinence (incontinence) and/or pelvic organ prolapse (prolapse). In Australia, as in many other countries, the harms caused by mesh eventually prompted individual and collective attempts to achieve redress. The rise of mesh surgery as a procedure, the experience of mesh‐affected women and the formal inquiries and legal actions that followed all occurred in social, cultural and discursive contexts. One strategy to understand these contexts is to track how the mesh and key actors in the mesh stories have been portrayed in mass media sources. We conducted a media analysis of the most highly read Australian newspapers and online news media platforms, focusing on how mesh and the interaction of stakeholders in mesh stories were presented to the Australian public.MethodWe searched systematically in the top 10 most‐read print and online media outlets in Australia. We included all articles that mentioned mesh, from the date of first use of mesh in Australia to the date of our final search (1996–2021).ResultAfter early scant media reporting focusing on the benefits of mesh procedures, major Australian medicolegal processes created a hook to shift reporting about mesh. The news media then played a significant role in redressing women's experienced epistemic injustice, including by amplifying previously ignored evidence of harm. This created an opportunity for previously unreported suffering to be revealed to powerful actors, in settings beyond the immediate control and epistemic authority of healthcare stakeholders, validating women's testimony and creating new hermeneutic resources for understanding mesh. Over time, media reports show healthcare stakeholders responding sympathetically to these new understandings in public discourse, contrasting with their statements in earlier media coverage.ConclusionWe argue that mass media reporting, in synergy with medicolegal actions and the Australian Senate Inquiry, appears to have provided women with greater epistemic justice, giving their testimony privileged epistemic status such that it was considered by powerful actors. Although medical reporting is not recognised in the hierarchy of evidence embedded in the medical knowledge system, in this case, media reporting appears to have contributed to shaping medical knowledge in significant ways.Patient or Public ContributionWe used publicly available data, print and online media outlets, for our analysis. Therefore, this manuscript does not contain the direct contribution of patients, service users, caregivers, people with lived experience or members of the public.