bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring electroencephalographic infraslow neurofeedback treatment for chronic low back pain: a double-blinded safety and feasibility randomized placebo-controlled trial
Authors: Adhia Divya Bharatkumar , Mani Ramakrishnan , Mathew Jerin , O’Leary Finella , Smith Mark , Vanneste Sven , De Ridder Dirk 
Published: January 2023

AbstractChronic low back pain (CLBP) is a disabling condition worldwide. In CLBP, neuroimaging studies demonstrate abnormal activities in cortical areas responsible for pain modulation, emotional, and sensory components of pain experience [i.e., pregenual and dorsal anterior cingulate cortex (pgACC, dACC), and somatosensory cortex (SSC), respectively]. This pilot study, conducted in a university setting, evaluated the feasibility, safety, and acceptability of a novel electroencephalography-based infraslow-neurofeedback (EEG ISF-NF) technique for retraining activities in pgACC, dACC and SSC and explored its effects on pain and disability. Participants with CLBP (n = 60), recruited between July’20 to March’21, received 12 sessions of either: ISF-NF targeting pgACC, dACC + SSC, a ratio of pgACC*2/dACC + SSC, or Placebo-NF. Descriptive statistics demonstrated that ISF-NF training is feasible [recruitment rate (7 participants/month), dropouts (25%; 20–27%), and adherence (80%; 73–88%)], safe (no adverse events reported), and was moderate to highly acceptable [Mean ± SD: 7.8 ± 2.0 (pgACC), 7.5 ± 2.7 (dACC + SCC), 8.2 ± 1.9 (Ratio), and 7.7 ± 1.5 (Placebo)]. ISF-NF targeting pgACC demonstrated the most favourable clinical outcomes, with a higher proportion of participants exhibiting a clinically meaningful reduction in pain severity [53%; MD (95% CI): − 1.9 (− 2.7, − 1.0)], interference [80%; MD (95% CI): − 2.3 (− 3.5, − 1.2)], and disability [73%; MD (95% CI): − 4.5 (− 6.1, − 2.9)] at 1-month follow-up. ISF-NF training is a feasible, safe, and an acceptable treatment approach for CLBP.
Machine learning identifies T cell receptor repertoire signatures associated with COVID-19 severity
Authors: Park Jonathan J. , Lee Kyoung A V. , Lam Stanley Z. , Moon Katherine S. , Fang Zhenhao , Chen Sidi 
Published: January 2023

AbstractT cell receptor (TCR) repertoires are critical for antiviral immunity. Determining the TCR repertoire composition, diversity, and dynamics and how they change during viral infection can inform the molecular specificity of host responses to viruses such as SARS-CoV-2. To determine signatures associated with COVID-19 disease severity, here we perform a large-scale analysis of over 4.7 billion sequences across 2130 TCR repertoires from COVID-19 patients and healthy donors. TCR repertoire analyses from these data identify and characterize convergent COVID-19-associated CDR3 gene usages, specificity groups, and sequence patterns. Here we show that T cell clonal expansion is associated with the upregulation of T cell effector function, TCR signaling, NF-kB signaling, and interferon-gamma signaling pathways. We also demonstrate that machine learning approaches accurately predict COVID-19 infection based on TCR sequence features, with certain high-power models reaching near-perfect AUROC scores. These analyses provide a systems immunology view of T cell adaptive immune responses to COVID-19.
Neurorehabilitation for the Uninsured: Georgia Rehabilitation Services Volunteer Partnership Clinic
Authors: Haarbauer-Krupa Juliet , Eugene DaJuandra , Wallace Tracey , Johnson Susan 
Published: January 2023

Purpose:
Individuals who experience brain injury and are uninsured often do not have access to health care services following their injury. The Georgia Rehabilitation Services Volunteer Partnership (GA RSVP) Clinic is a free outpatient rehabilitation program for uninsured individuals with acquired brain injury (ABI) and/or spinal cord injury (SCI) for all racial and ethnic backgrounds. While the clinic serves people with ABI and SCI, this clinical focus article will focus on people with ABI by describing the clinic, lessons learned from operations, an ABI patient case study, and future directions.

Method:
Our mission is to provide free outpatient rehabilitation care that maximizes independence, wellness, and community participation. The clinic has been in operation since September 2020, staffed by volunteers who provide services once a month in donated space at a rehabilitation hospital. We currently have 69 active volunteers, seven founding Board of Directors, and 17 founding Advisory Board members. We provide education to clients and their families and run peer and family support groups. For clients who cannot attend due to medical or transportation challenges, we have added telehealth services. We have 11 partner organizations as well as individual donor's financial support. The Chair of the clinic volunteers 50% of time managing clinic operations.

Results:
From September 2020 to December 2021, we provided care for 40 clients: 23 clinic admissions and 17 were provided information/referral services to access necessary health care services.

Conclusions:
A volunteer, free outpatient rehabilitation clinic is feasible and can contribute to improved outcomes for uninsured individuals with ABI. Further research to understand impact on patient outcomes is needed.
Effectiveness of Constraint-Induced Language Therapy for Aphasia: Evidence From Systematic Reviews and Meta-Analyses
Authors: Raymer Anastasia M. , Roitsch Jane 
Published: January 2023

Purpose:
Constraint-induced language therapy (CILT) is an aphasia treatment that incorporates neuroplasticity principles of forced verbal use and high-intensity training to facilitate language recovery in individuals with stroke-induced aphasia (Pulvermüller et al., 2001). The burgeoning CILT literature has led to systematic reviews (SRs) that summarize treatment results. In this project, we appraised the quality and examined findings reported in several SRs to draw conclusions about the effectiveness of CILT.

Method:
We searched multiple databases for SRs that summarized CILT research for poststroke aphasia. We identified six SRs, among which three summarized findings qualitatively and three included meta-analysis (MA) to quantify results. We rated each SR for methodologic quality using the A MeaSurement Tool to Assess Systematic Reviews (AMSTAR 2; Shea et al., 2017) and extracted findings across the six SRs.

Results:
Two reviewers reliably applied the AMSTAR 2 to the six SRs. Although the six SRs generally were conducted with satisfactory rigor, each was lacking two or more critical domains. Descriptive summaries in SRs reported positive effects of CILT for language and communication measures. However, the three MAs showed that effects of CILT often did not surpass those of comparison treatments for naming, comprehension, and repetition measures. MA findings were positive in a review that included all research designs and evaluated treatment effects for trained naming items. Generalized CILT effects for standardized language measures were limited in two other MAs.

Conclusions:
CILT led to improvements in a variety of language and communication measures. When compared with intensive multimodality treatments, CILT effects were similar, suggesting that training intensity may be the potent factor in CILT outcomes. Future SRs should be implemented with increased rigor across quality rating scale domains to increase confidence in conclusions.
Computational synthesis of control barrier functions with applications in automotive lane keeping supervisory control
Authors: Duan Yue , Zeng Xiangrui 
Published: January 2023

AbstractThe control barrier function (CBF) provides a good tool to design supervisory controllers for safety‐critical systems. However, constructing a CBF for a general nonlinear system is a challenging task. This paper presents a general CBF computational synthesis approach for nonlinear affine systems with state constraints and input constraints using sum‐of‐squares (SOS) programming. System dynamics and state constraints are approximated using polynomial functions, and the input constraints are approximated using linear functions. The CBF synthesis algorithm is presented step‐by‐step, and tricks to deal with potential numerical issues during the SOS optimizations are discussed. The proposed algorithm is applied to an automotive lane keeping application to synthesize a CBF, and a supervisory control based on this CBF is designed. The effectiveness and resilience of this CBF‐based supervisory control against disturbance are illustrated in simulation with a 14‐degree‐of‐freedom vehicle dynamics model. Results show that this CBF‐based supervisory control can improve the resilience of nominal controllers in automotive lane keeping applications.
Crystallisation regulation of long‐chain branched polypropylene on dielectric performance and energy density for metallised film capacitors
Authors: Xiao Meng , Zhang Mengdie , Du Boxue 
Published: January 2023

AbstractThe degradation of dielectric properties of polypropylene (PP) at high temperature affects the operational stability of metallised film capacitors. This study presents a method to improve the high‐temperature dielectric performance of PP through long‐chain branching modification and regulating the crystalline properties. Different amounts of nucleating agents were added to long‐chain branched polypropylene (LCBPP) to study the effect of crystallisation on electrical properties. The results show that the long‐chain branches improve thermal stability by enhancing the chain entanglement, and also increase the number of crystals due to heterogeneous nucleation. The addition of nucleating agents promotes the crystallisation of LCBPP, which increases the nucleation density and improves the crystallinity. The regulation of the microstructure of PP suppresses the relaxation of the chains and limits the charge transport. The dielectric constant of the modified films with long‐chain branching is slightly increased, and the doping of nucleating agents has little effect on the dielectric constant and loss of LCBPP. At 125°C, the conductivity of the modified LCBPP films with the addition of 0.05 wt% nucleating agent decreased by 2 orders of magnitude and the breakdown strength increased by 26.3%. This study has implications for improving the dielectric properties of PP films.
Cascaded deep NN‐based customer participation by considering renewable energy sources for congestion management in deregulated power markets
Authors: Agrawal Anjali , Walde Pratima , Pandey Seema N. , Srivastava Laxmi , Saket R. K. , Khan Baseem 
Published: January 2023

AbstractContinuously varying loading conditions and the cost‐based operation of a competitive power market lead to the problem of congestion as one of the most crucial issues. In day‐ahead power market operation (PMO), customer participation (CP) and generation rescheduling (GR) are the most effective techniques preferred by the system operator to eliminate congestion. In this paper, a cascaded Deep Neural Network (DNN) module has been presented for estimating customer participation and power generated by Wind Energy Source (WES) as on‐site generation (OSG) to manage congestion. The proposed module is a cascade combination of Artificial Neural Network (ANN) as a filtering module (FM) and DNN as a congestion management (CM) module. The CM module estimates the customer participation for all receptive costumers, power supplied by wind energy sources under uncertain conditions and generation rescheduling of all generators with minimum cost for all unseen congested power system loading patterns. The proposed CM approach provides an instant and efficient solution to manage congestion with minimum cost. The developed module has been examined on IEEE 30‐bus power system. The maximum error found in the testing phase is 1.1865% which is very less and within the acceptable limit.
A novel adaptive neuro linear quadratic regulator (ANLQR) controller design on DC‐DC buck converter
Authors: Roosta Vahid , Ghamari Seyyed Morteza , Mollaee Hasan , Zarif Mohammad Hadad 
Published: January 2023

AbstractThis paper proposes an Adaptive Neuro Linear Quadratic Regulator (ANLQR) controller for Buck converter operating under harmful disturbances. Considering the real‐time condition of a converter with regular variations, Neural Network is adopted to improve and tune the gain of the LQR strategy with an adaptive mechanism. This strategy assumes the system as a Gray‐box process without the need for the exact mathematical model of the system which can result in lower computational burden, faster dynamics, and ease of implementation. ANLQR control strategy is a suitable alternative considering its significant robustness against different disturbances, particularly noise. It should be mentioned that the number of neurons is limited to 2 and 4 in each layer to decrease the computational burden with lower complexity. The advantages of this ANLQR method is justified for various operating situations through experimental and simulation outcomes. Moreover, LQR and PSO‐PID controllers are designed and compared with the presented strategy to carry on a comparison with the proposed method. Furthermore, this approach provides better outcomes with faster dynamics and better frequency adaption in the real‐time environments.
Low-order wavefront control using a Zernike sensor through Lyot coronagraphs for exoplanet imaging
Authors: Pourcelot R. , Por E. H. , N’Diaye M. , Benard H. , Brady G. , Canas L. , Carbillet M. , Dohlen K. , Laginja I. , Lugten J. , Noss J. , Perrin M. D. , Petrone P. , Pueyo L. , Redmond S. F. , Sahoo A. , Vigan A. , Will S. D. , Soummer R. 
Published: January 2023

Context. Wavefront sensing and control (WFSC) will play a key role in improving the stability of future large segmented space telescopes while relaxing the thermo-mechanical constraints on the observatory structure. Coupled with a coronagraph to reject the light of an observed bright star, WFSC enables the generation and stabilisation of a dark hole (DH) in the star image to perform planet observations.
Aims. While WFSC traditionally relies on a single wavefront sensor (WFS) input to measure wavefront errors, the next generation of instruments will require several WFSs to address aberrations with different sets of spatial and temporal frequency contents. The multiple measurements produced in such a way will then have to be combined and converted to commands for deformable mirrors to modify the wavefront subsequently.
Methods. We asynchronously operate a loop controlling the high-order modes digging a DH and a control loop that uses the rejected light by a Lyot coronagraph with a Zernike wavefront sensor to stabilize the low-order aberrations. Using the HiCAT testbed with a segmented telescope aperture, we implement concurrent operations and quantify the expected cross-talk between the two controllers. We then present experiments that alternate high-order and low-order control loops to identify and estimate their respective contributions.
Results. We show an efficient combination of the high-order and low-order control loops, keeping a DH contrast better than 5 × 10−8 over a 30 min experiment and stability improvement by a factor of 1.5. In particular, we show a contrast gain of 1.5 at separations close to the DH inner working angle, thanks to the low-order controller contribution.
Conclusions. Concurrently digging a DH and using the light rejected by a Lyot coronagraph to stabilize the wavefront is a promising path towards exoplanet imaging and spectroscopy with future large space observatories.
Adult Clinical Perfusion Practice Survey: 2020 results
Authors: Lohbusch Breana , Olson Kaylee , Magowan Benjamin , Cherichella Robert , Wolverton Jeremy , Dell’Aiera Laura , Likosky Donald S. , Fitzgerald David 
Published: January 2023

Background: Cardiovascular perfusion is a dynamic healthcare profession where new practices are frequently introduced. Despite the emergence of evidence-based clinical practice guidelines, little is known about their dissemination at the institutional level. Clinical practice surveys have been used to identify current trends in perfusion practice in the areas of equipment, techniques, and staffing. This survey aims to describe clinical perfusion practices across adult cardiac surgical programs located in a large, single, geographical region of the United States.Methods: Following Institutional Review Board (IRB) approval, an 81-question survey was distributed to 167 adult perfusion programs across the Zone IV region of the American Society of Extracorporeal Technology (AmSECT), a non-profit professional society representing the extracorporeal technology community. Surveys were distributed to chief perfusionists through the Research Electronic Data Capture (REDCap) web-based survey response system.Results: Responses were received from 58 of 167 centers across (34.7% response rate). Centrifugal pumps were used at 81% (n = 47) of centers and 96.6% (n = 56) use an open venous system or hard-shell venous reservoir. Del Nido was the most frequently used cardioplegia strategy with 62.1% (n = 36) of centers reporting its use. The use of electronic medical records was reported in 43% (n = 25) of centers, while 84.5% (n = 49) reported using Cardiopulmonary Bypass (CPB) protocols (>75% of all CPB activities). Extracorporeal Membrane Oxygenation (ECMO) support was reported in 93.1% (n = 54) of programs, with 59.2% of programs (n = 34) employing a perfusionist as ECMO Coordinator. Then + 1 staffing model was reported by 50% (n = 29), with 24% supporting then + 1 staffing for after-hours and on-call procedures.Conclusion: Clinical practice surveys can be effective tools to inform clinicians about contemporary perfusion practice and identify deviations from professional standards and guidelines. Subsequent surveys may describe trends over time, assess standardization of practice, measure adherence to evidence-based guidelines, and foster improved patient care and outcomes.
Les couleurs des verres
Authors: Lelong Gérald , de Ligny Dominique 
Published: January 2023

Des billes de notre enfance aux vitraux des cathédrales, le verre coloré exerce sur nous une grande fascination. La coloration du verre, souvent voulue pour donner un aspect esthétique ou protéger le contenu, est aussi parfois subie du fait de la présence d’impuretés comme le fer. Même à très faible concentration, le fer peut colorer le verre du vert au jaune en passant par le bleu.
Nous allons ici expliquer que les colorations sont principalement obtenues de manière soustractive par des centres actifs, tels que les métaux de transition et les nanoparticules. D’autres effets physiques, comme la photoluminescence ou les interactions photoniques, peuvent également induire des colorations.
Propionate exerts neuroprotective and neuroregenerative effects in the peripheral nervous system
Authors: Grüter Thomas , Mohamad Nuwin , Rilke Niklas , Blusch Alina , Sgodzai Melissa , Demir Seray , Pedreiturria Xiomara , Lemhoefer Katharina , Gisevius Barbara , Haghikia Aiden , Fisse Anna Lena , Motte Jeremias , Gold Ralf , Pitarokoili Kalliopi 
Published: January 2023

In inflammatory neuropathies, oxidative stress results in neuronal and Schwann cell (SC) death promoting early neurodegeneration and clinical disability. Treatment with the short-chain fatty acid propionate showed a significant immunoregulatory and neuroprotective effect in multiple sclerosis patients. Similar effects have been described for patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Therefore, Schwann cell’s survival and dorsal root ganglia (DRG) outgrowth were evaluated in vitro after propionate treatment and application of H2O2 or S-nitroso-N-acetyl-D-L-penicillamine (SNAP) to evaluate neuroprotection. In addition, DRG resistance was evaluated by the application of oxidative stress by SNAP ex vivo after in vivo propionate treatment. Propionate treatment secondary to SNAP application on DRG served as a neuroregeneration model. Histone acetylation as well as expression of the free fatty acid receptor (FFAR) 2 and 3, histone deacetylases, neuroregeneration markers, and antioxidative mediators were investigated. β-hydroxybutyrate was used as a second FFAR3 ligand, and pertussis toxin was used as an FFAR3 antagonist. FFAR3, but not FFAR2, expression was evident on SC and DRG. Propionate-mediated activation of FFAR3 and histone 3 hyperacetylation resulted in increased catalase expression and increased resistance to oxidative stress. In addition, propionate treatment resulted in enhanced neuroregeneration with concomitant growth-associated protein 43 expression. We were able to demonstrate an antioxidative and neuroregenerative effect of propionate on SC and DRG mediated by FFAR3-induced histone acetylases expression. Our results describe a pathway to achieve neuroprotection/neuroregeneration relevant for patients with immune-mediated neuropathies.
Noncollinear antiferromagnetic textures driven high-harmonic generation from magnetic dynamics in the absence of spin-orbit coupling
Authors: Ly Ousmane 
Published: January 2023

Abstract
We demonstrate the generation of high order harmonics in carrier pumping from precessing ferromagnetic or antiferromagnetic orders, excited via magnetic resonance, in the presence of topological antiferromagnetic textures. This results in an enhancement of the carrier dynamics by orders of magnitude, enabling for an emission deep in the THz frequency range. Interestingly, the generation process occurs in an intrinsic manner, and is solely governed by the interplay between the s-d exchange coupling underlying the noncollinear antiferromagnetic order and the dynamical s-d exchange constant of the magnetic drive. Therefore, the relativistic spin–orbit interaction is not required for the emergence of high harmonics in the pumped currents. Accordingly, the noncollinear topological antiferromagnetic order is presented as an alternative to spin–orbit interaction for the purpose of harnessing high harmonic emission in carrier pumping. Furthermore, we demonstrate the emergence of high harmonics from random magnetic impurities. This suggests the universality of the magnetically induced high harmonic emission in the presence of real and/or momentum space noncollinear textures. Our proposal initiates a tantalizing prospect for the utilization of topological textures in the context of the highly active domains of ultrafast spintronics and THz emission.
Towards atom manufacturing with framework nucleic acids
Authors: Chen Xiaoliang , Yan Bingjie , Yao Guangbao 
Published: January 2023

Abstract
Atom manufacturing has become a blooming frontier direction in the field of material and chemical science in recent years, focusing on the fabrication of functional materials and devices with individual atoms or with atomic precision. Framework nucleic acids (FNAs) refer to nanoscale nucleic acid framework structures with novel properties distinct from those of conventional nucleic acids. Due to their ability to be precisely positioned and assembled at the nanometer or even atomic scale, FNAs are ideal materials for atom manufacturing. They hold great promise for the bottom-up construction of electronic devices by precisely arranging and integrating building blocks with atomic or near-atomic precision. In this review, we summarize the progress of atom manufacturing based on FNAs. We begin by introducing the atomic-precision construction of FNAs and the intrinsic electrical properties of DNA molecules. Then, we describe various approaches for the fabrication of FNAs templated materials and devices, which are classified as conducting, insulating, or semiconducting based on their electrical properties. We highlight the role of FNAs in the fabrication of functional electronic devices with atomic precision, as well as the challenges and opportunities for atom manufacturing with FNAs.