bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Overview of Biosynthetic Pathway and Therapeutic Potential of Rutin
Authors: Goyal Jugnu , Verma Prabhakar Kumar 
Published: January 2023

Abstract:
Flavonoids are compounds abundantly found in nature and known as a polyphenolic group
of compounds having flavancore and show the utmost abundant collection of complexes and are
found in fiber-rich root vegetables, fruits, and their eatable items. Due to the presence of hydroxyl
groups, flavonoids show various therapeutic activities like antioxidant, antibacterial, antiviral, and
anti-inflammatory. Substituent groups are responsible for the onset of biochemical actions of flavonoids,
which affect the metabolism. The major example of flavonol is rutin, which is constituted of
rutinose and quercetin. It is a glycosidic type of flavonoid, similarly identified as purple quercitrin and
Vitamin P with over 70 plant species and plant-derived foods, exclusively grapefruit, buckwheat
seeds, cherries, apricots, grapes, onions, plums, and oranges. Another name forrutin is a citrus flavonoid
known as rutoside, and sophorin. Rutin is a polyphenolic compound having a low molecular
weight.
In silico Identification of HDAC Inhibitors for Multiple Myeloma: A
Structure-based Virtual Screening, Drug Likeness, ADMET Profiling,
Molecular Docking, and Molecular Dynamics Simulation Study
Authors: Debnath Abhijit , Mazumder Rupa , Mazumder Avijit , Singh Rajesh , Srivastava Shikha 
Published: January 2023

Background:
Multiple myeloma (MM) is a hematological malignancy of plasma cells that
produce a monoclonal immunoglobulin protein. Despite significant advances in the treatment of MM,
currently available therapies are associated with toxicity and resistance. As a result, there is an increasing
demand for novel, effective therapeutics. Inhibition of histone deacetylases (HDACs) is emerging as a
potential method for treating cancer. HDAC6 is one of 18 different HDAC isoforms that regulate tubulin
lysine 40 and function in the microtubule network. HDAC6 participates in tumorigenesis and metastasis
through protein ubiquitination, tubulin, and Hsp90. Several studies have found that inhibiting HDAC6
causes AKT and ERK dephosphorylation, which leads to decreased cell proliferation and promotes cancer
cell death via the PI3K/AKT and MAPK/ERK signaling pathways.

Objective:
The objective of this study is to target HDAC6 and identify potent inhibitors for the treatment
of multiple myeloma by employing computer-aided drug design.

Materials and Methods:
A total of 199,611,439 molecules from five different chemical databases, such
as CHEMBL25, ChemSpace, Mcule, MolPort, and ZINC, have been screened against HDAC6 by structure-
based virtual screening, followed by filtering for various drug-likeness, ADME, toxicity, consensus
molecular docking, and 100 ns MD simulation.

Results:
Our research work resulted in three molecules that have shown strong binding affinity
(CHEMBL2425964 -9.99 kcal/mol, CHEMBL2425966 -9.89 kcal/mol, and CSC067477144 -9.86
kcal/mol) at the active site HDAC6, along with effective ADME properties, low toxicity, and high stability.
Inhibiting HDAC6 with these identified molecules will induce AKT and ERK dephosphorylation
linked to reduced cell proliferation and promote cancer cell death.

Conclusion:
CHEMBL2425964, CHEMBL2425966, and CSC067477144 could be effective against multiple
myeloma.
Pituitary Adenoma with Multiple Calcifications in a Child: A Rare Case
Presentation
Authors: Wang Juan , Zhao Xinyu , Zhang Wei 
Published: January 2023

Introduction:
Pediatric pituitary adenomas are rare, resulting in a limited amount of literature
on these patients. The incidence of calcification in adult patients with pituitary adenomas is only
0.2% to 8%, while the incidence of calcification in children has not been reported.

Case Report:
In this paper, we report a 10-year-old girl with a calcified pituitary adenoma. Laboratory
examination showed the growth hormone (GH) to be more than 50ug/L, and pituitary prolactin (PRL)
was 27.42 ng/mL. Non-contrast-enhanced computed tomography (CT) scans indicated a large sellar
occupation with multiple nodules of calcification. Subsequently, the patient underwent a transcranial
resection. Histopathologic evaluation confirmed the diagnosis of pituitary adenoma with multiple calcifications.

Conclusion:
Since the management and prognosis of adenomas with calcification from other occupations
of the pituitary gland differ significantly, it is important to differentiate between the two.
One-step Nonenzymatic Electrochemical Sensor for the Detection of
Sarcosine Using Nanozyme Glutathione Copper Complex
Authors: Udayakumar Janani , Selvaraj Stalin 
Published: January 2023

Background:
The present study aims to develop the use of glutathione copper complex for the
detection of sarcosine, a marker for prostate cancer. The glutathione-copper complex was successfully
synthesized at room temperature and characterized using FTIR, UV, and Scanning Electron Micrograph.

Methods:
The structure of the glutathione copper complex was found to be a 1:2 Metal: Ligand ratio. The
cyclic voltammogram for the glutathione-copper complex modified electrode showed an oxidation peak
around -0.037 V, which indicates the irreversible oxidation of copper ions. The addition of sarcosine decreased
the oxidation potential of the glutathione copper complex indicating the ability of the working
electrode, for the detection of sarcosine in the sample using differential pulse voltammetry.

Results:
The results indicated that the glutathione-copper complex modified electrode revealed good sensitivity,
selectivity, and linearity against the detection of sarcosine in the range from 0.1 μM to 2.5 μM.
The LOD and LOQ were calculated using a linear prediction model, the data obtained from differential
pulse voltammetry technique for known and simulated urine samples was 0.72 μM, 5.13 μM, and 1.45
μM, 39.94 μM, respectively. The sensitivity for the developed working electrode obtained for the known
and simulated sample was 0.0567 μA/μM and 0.02913 μA/μM, respectively.

Conclusion:
Thus, we concluded that the glutathione copper complex decorated glassy carbon electrode
is a good candidate for the detection of sarcosine with good selectivity and sensitivity for real-time monitoring.
Seed Oils in Treatment of Skin Aging and Photoaging
Authors: Kothapalli Lata , Raut Vaidehi , Thomas Asha 
Published: January 2023

Background:
Seed oils have been exploited for an array of purposes with their addition
to dietary, cosmetics, or therapeutic products. The process of skin aging is a natural and complex
phenomenon in living beings. Skin aging is classified into two independent processes, i.e., chronological
aging and premature aging. Aging is observed as a loss of strength and elasticity of the skin,
leading to wrinkles on the skin. It is due to a decrease in various components of the skin matrix,
like elastin, collagen, and hyaluronic acid. Furthermore, aging is potentiated by excessive exposure
to UV radiation (Photoaging) and can be prevented or reduced by using products that combat photoaging.

Objective:
Anti-aging and antiwrinkle agents are in demand for maintaining skin tone. Seed oils
composed of polyunsaturated fatty acids are traditionally used in cosmetic products as moisturizers
and emollients, while palmitic acid and oleic acid are known for their penetration-enhancing effect.
With the changing trend for extraction of oils like cold pressed methods, seed oils enriched with
polyphenols, flavonoids, carotenoids, and phytosterols are good antioxidants and antimicrobials
and therefore have an ever-growing demand for their usage in the treatment of skin diseases. In this
review, an attempt will be made to brief the phytoconstituents present in various seed oils and their
utilization against skin ailments. Furthermore, a mechanistic approach towards the benefit of oils in
skin barrier repair, antiaging, and photo-aging with the help of extensive well-designed clinical trials
carried out in the recent past is elaborated.

Methods:
A literature search in the Scopus database, Pubmed, and Medline was carried out using
the terminology “aging, photoaging, antioxidant, UV-protection, sunscreens, skin barrier repair,
and fatty acids, formulations” in the study. Data were retrieved over the last twenty years.

Results:
The review summarises the mechanistic approach and beneficial application of seed oils
for healthy and glowing skin. The oils obtained from olives, sesame, borage, grape seeds, and carrot
seeds have multitargeted effects. However, the variation in pharmacological effect may vary
based on geographically differing varieties, skin type, and person-to-person variation. The need to
standardize the varieties for their phytoactive ingredients and the composition of formulation used
for skin care can help utilize the seeds as a potential source of actives against skin diseases.

Conclusion:
The potential of seed oils can be increased with appropriate analytical tools, validation
protocols, and systematic experimental studies at preclinical and clinical trials for their application
to skin care products.
دعوى الغير في منازعات إنهاءالعقود الادارية (دراسة مقارنة)
Authors: Ismael Ali Youns , Muhammad Jamila Awmar 
Published: January 2023

- ليس بالضرورة أن يقتصر أثر العقد الاداري أطرافه وحسب، فقد يرتب اثاراً تمتد الى الغير، ويعد ذلك استثناءً من قاعدة نسبية آثار العقد، ومفهوم الغير في العقود الادارية يختلف تبعاً للمرحلة التي يمر بها العقد، فالغير في مرحلة تكوين العقد يختلف عن الغير في مرحلة تنفيذ العقد، وكذلك يختلف مفهوم الغير من عقد لاخر، وإذا كان للغير الأجنبي، ذي المصلحة، الحق في اللجوء الى القضاء والطعن بالقرارات القابلة للانفصال عن العقد، فقد حدث تطوراً في إتجاه القضاء الفرنسي والمصري فيما يتعلق بطعون الغير أمام قاضي العقد نفسه، حيث جرى قبول لجوء الغير الى لطعن في صحة العقد وطلب إنهائه عن طريق دعوى القضاء الكامل اذا كان له مصلحة مباشرة ومحددة بشكل كافي، وقاضي العقد يملك سلطة تقديرية في إستجابة طلب الغير بإنهاء العقد الاداري من عدمه مع الأخذ في الحسبان عدم الإضرار بالمصلحة العامة. وهذا عكس ما يجري العمل به في العراق، حيث لا يملك الغير الا اللجوء الى قاضي الالغاء للطعن في القرارات القابلة للانفصال.
Acceptability of a Health Care App With 3 User Interfaces for Older Adults and Their Caregivers: Design and Evaluation Study
Authors: Kim Joo Chan , Saguna Saguna , Åhlund Christer 
Published: January 2023

Background
The older population needs solutions for independent living and reducing the burden on caregivers while maintaining the quality and dignity of life.

Objective
The aim of this study was to design, develop, and evaluate an older adult health care app that supports trained caregivers (ie, formal caregivers) and relatives (ie, informal caregivers). We aimed to identify the factors that affect user acceptance of interfaces depending on the user’s role.

Methods
We designed and developed an app with 3 user interfaces that enable remote sensing of an older adult’s daily activities and behaviors. We conducted user evaluations (N=25) with older adults and their formal and informal caregivers to obtain an overall impression of the health care monitoring app in terms of user experience and usability. In our design study, the participants had firsthand experience with our app, followed by a questionnaire and individual interview to express their opinions on the app. Through the interview, we also identified their views on each user interface and interaction modality to identify the relationship between the user’s role and their acceptance of a particular interface. The questionnaire answers were statistically analyzed, and we coded the interview answers based on keywords related to a participant’s experience, for example, ease of use and usefulness.

Results
We obtained overall positive results in the user evaluation of our app regarding key aspects such as efficiency, perspicuity, dependability, stimulation, and novelty, with an average between 1.74 (SD 1.02) and 2.18 (SD 0.93) on a scale of −3.0 to 3.0. The overall impression of our app was favorable, and we identified that “simple” and “intuitive” were the main factors affecting older adults’ and caregivers’ preference for the user interface and interaction modality. We also identified a positive user acceptance of the use of augmented reality by 91% (10/11) of the older adults to share information with their formal and informal caregivers.

Conclusions
To address the need for a study to evaluate the user experience and user acceptance by older adults as well as both formal and informal caregivers regarding the user interfaces with multimodal interaction in the context of health monitoring, we designed, developed, and conducted user evaluations with the target user groups. Our results through this design study show important implications for designing future health monitoring apps with multiple interaction modalities and intuitive user interfaces in the older adult health care domain.
Respiratory syncytial virus infection disrupts pulmonary microbiota and immune barriers to induce microglia phenotype shift
Authors: Tan Yurong , Bajinka Ousman , Tang Zhongxiang , Mao Yu , Qiu Xiangjie , Darboe Alansana 
Published: January 2023

Background: The lung-brain-axis is an emerging biological
pathway that is being investigated in relation to microbiome medicine.
Increasing evidence suggest that pulmonary viral infections can lead to
distinct pathological imprints in the brain, thereby the need to explore
and understand this mechanism and find possible interventions.
Objective: This study used RSV infection in mice as a model to
establish the potential lung-brain axis phenomenon. We hypothesized that
RSV infection could disrupt the lung microbiota, thereby compromising
the immune barriers and thus induces significant shift in microglia
phenotype. Methods: Mice were randomized into the Control,
Ampicillin, RSV, and RSV+Ampicillin treated groups (n = 6 each).
Ampicillin was given intratracheal instillation and seven days after the
respective treatments, the mice were anesthetized. Hematoxylin-eosin
(HE) staining of lung tissue to detect histopathology.
Immunofluorescence label of specific target antigens in both the lung
and brain tissues, namely, Malondialdehyde (MDA) and Superoxide
dismutase (SOD) were used as markers of cellular damage. RT-qPCR was
used to detect viral RNA in both tissues, ELISA to
measure IL-1β, iNOS, IL-10 and Arg1 in the supernatant and 16s DNA
technology were used to detect the lung microflora. Results:
We found out that RSV infection induces elevated oxidative stress,
reduced anti-oxidant and caused significant dysbacteriosis in the lungs
of the mice. Pulmonary microbes were found affecting Th1-type
immunoreactivity induced by RSV infection and eventually, microbiota in
lung induced microglia phenotype shift in the brain of the mice.
Conclusion. This study was able to establish that RSV infection
can disrupt the pulmonary microbiome and immune barriers to
induce microglia phenotype shift. Thus, we recommend a large sample size
study with robust data analysis for the long-term effects of antibiotics
and RSV infection on brain physiology.
Site-specific fracture incidence rates among patients with type 1 diabetes, type 2 diabetes or without diabetes in Denmark (1997-2017)
Authors: Kvist Annika Vestergaard , Nasser Mohamad I. , Vestergaard Peter , Frost Morten , Burden Andrea M. 
Published: January 2023

<p> </p>
<p><strong>Objective: </strong>To investigate trends of incidence rates at different fracture sites for patients with type 1 diabetes and type 2 diabetes compared to patients without diabetes in Denmark in 1997-2017.</p>
<p><strong>Research Design and Methods: </strong>Patients aged 18+ with a vertebral, hip, humerus, forearm, foot, or ankle fracture between 1997 and 2017 were identified from Danish hospital discharge data. Incidence rates (IRs) per 10,000 person years were calculated over the study period. Median IRs for the first (1997-2001) and the last (2013-2017) five years were compared. We estimated age-adjusted IR ratios (IRRs) of fractures among patients with type 1 and type 2 diabetes to patients without diabetes, using Poisson models.</p>
<p><strong>Results: </strong>Except for foot fractures, fracture IRs were higher in patients with type 1 or 2 diabetes compared to patients without diabetes. Hip fracture IRs declined between the first and last five years by 35.2%, 47.0% and 23.4% among patients with type 1 diabetes, type 2 diabetes, and patients without diabetes, respectively. By contrast, vertebral fracture IRs increased 14.8%, 18.5%, 38.9% in patients with type 1 diabetes, type 2 diabetes and patients without diabetes, respectively. While age-adjusted IRRs remained elevated in patients with type 1 diabetes compared to patients without diabetes, IRRs in patients with type 2 diabetes converged with those observed in patients without diabetes. </p>
<p><strong>Conclusion: </strong>Unadjusted fracture rates are higher in patients with diabetes but have decreased between 1997 and 2017 except for vertebral fractures that increased in all groups. Fracture rates change after age-adjustment. </p>
ANALISIS SENTIMEN DENGAN PENDEKATAN ENSEMBLE LEARNING DAN WORD EMBEDDING PADA TWITTER
Authors: Daniati Erna , Utama Hastari 
Published: January 2023

Twitter merupakan media sosial yang sering digunakan dimana mencapai 284 juta pengguna aktif dan setiap harinya lebih dari 500 juta tweet per hari. Hari ini menjadikan peluang emas bagi perusahaan dan individu untuk meningkatkan relasi sosial, politik, dan ekonomi yang kuat demi meningkatkan reputasi. Pada kumpulan tweet tersebut memuat opini yang berasal dari berbagai pengguna. Hal ini sangat potensial bagi perusahaan untuk menggali dan mendapatkan informasi mengenai jenis tweet ini. Selanjutnya, ekstrasi data yang disusun dalam bentuk Bag Of Word ini terdapat kekurangan. Fitur yang dihasilkan cukup banyak sehingga berpengaruh dalam waktu proses untuk pelatihan data. Metode Word2Vec memiliki keunggulan dalam menangkap hubungan sintaksis dan semantik antar kata. Pada penelitian ini berusaha untuk meningkatkan akurasi yang dicapai dengan penggunaan word embedding sebagai representasi teks dan ensemble learning dari pengklasifikasi yang digunakan. Hasil penelitian ini mampu menunjukkan tngkat akurasi yang lebih tinggi dalam penggunaan algoritma Adaboost dan Word2Vec.
Kata Kunci :
Ensemble Learning, Sentiment Analysis, Word Embedding, Twitter.
Porcupine quilling–associated pneumothorax in dogs: 25 cases (2001–2022)
Authors: Sevy Julia J. , Gottlieb Lauren , Vaught Meghan , Rozanski Elizabeth 
Published: January 2023

Abstract

OBJECTIVE
To describe the clinical outcome of dogs that developed pneumothorax after an encounter with a porcupine.

ANIMALS
25 client-owned dogs from 2 practices in New England.

PROCEDURES
The medical records were searched for those of dogs that underwent care for porcupine quilling–associated pneumothorax (PQAP) between August 1, 2001, and October 15, 2023. Dogs were all large-breed dogs or large mixed-breed dogs and most frequently had clinical signs associated with pneumothorax, including labored breathing and tachypnea.

RESULTS
No cases occurred in winter months. Diagnostic imaging was useful for identifying pneumothorax, but not for localizing quills. Twenty-one of the 25 dogs underwent median sternotomy for quill removal, with quills found in lung tissue of 19 dogs. Two dogs had no intrathoracic quills identified at thoracotomy, but residual quills were identified in the intercostal muscles. Four dogs were discharged without surgery after apparent resolution of the pneumothorax. All dogs survived to hospital discharge; however, 5 dogs required subsequent quill removal from ongoing quill migration.

CLINICAL RELEVANCE
Porcupine quillings may result in traumatic pneumothorax associated with quill migration. Following quill removal, monitoring for the development of a pneumothorax is advised. Surgical removal of quills from the lungs has a good prognosis.
Examining academicians’ COVID-19 anxiety and digitalisation in terms of different variables
Authors: Karakuş Gülçin 
Published: January 2023

Abstract
This study examines academicians’ COVID-19 anxiety and digitalisation regarding different variables. The sample of this study consists of 103 academicians from various universities. A survey model was used. The data collection tools were the “Coronavirus Anxiety Scale” to measure anxiety caused by COVID-19 and the “Academicians Digitalisation Scale” to determine academicians’ digitalisation. Results indicated that while there was a significant difference in academicians’ COVID-19 anxiety and digitalisation regarding different variables, there was no relationship between their COVID-19 anxiety and digitalisation.
SPI Memoderasi Pengaruh SIA, Tekanan Keuangan, Komitmen Organisasi dan Budaya Organisasi Pada Kecenderungan Kecurangan
Authors: Dewi Risma , Suardana Ketut Alit 
Published: January 2023

This study aims to determine the effect of accounting information systems, financial pressure, organizational commitment and organizational culture on fraud tendencies in Bangli Regency with the internal control system as a moderating variable. The research population is 34 Bangli Regency Regional Apparatus Organizations. Sampling using purposive sampling method and get as many as 60 respondents as research samples. Research data obtained from distributing questionnaires. Data analysis using moderation linear regression method. The results showed that accounting information systems and organizational culture had a significant negative effect on fraud tendencies, organizational commitment had a significant positive effect on fraud tendencies, but financial pressure and internal control systems had no significant effect. The results of the moderation analysis show that the internal control system is able to moderate the influence of accounting information systems, organizational commitment and organizational culture on fraud tendencies. The internal control system is unable to moderate the effect of financial pressure on fraud tendencies.
Keywords: Fraud Tendency; Government institution; Fraud Triangle; Internal Control System.
CSR dan Nilai Perusahaan: Peran Odd-Even Effect Dewan Direksi, Umur dan Ukuran Perusahaan
Authors: Dewi Ayu Aryista , Ariyanto Dodik 
Published: January 2023

Firm value is one indicator in investing. The study aims to examine the effect of Corporate Social Responsibility (CSR) on firm value by using firm age, board of directors odd-even effect and company size as moderating variables for companies listed on the Sri Kehati Index from 2013-2019. The research sample consisted of 84 observations and data were analyzed using multiple linear regression models and Moderated Regression Analysis (MRA). The results of the study show that CSR has a positive and significant effect on firm value. The results also show that firm age, board of directors odd-even effect and firm size moderate the relationship between CSR and firm value.
Keywords: Board Meeting Efficiency; Company Value; Corporate Social Responsibility; Company Size; Company Age
Pengetahuan Perpajakan, Kepatuhan Wajib Pajak dan Kesadaran Wajib Pajak Sebagai Pemediasi
Authors: Septyana Sarah , Anggiriawan Putu Budi , Yudha Cokorda Krisna 
Published: January 2023

The research aims to determine the effect of knowledge of taxation on taxpayer compliance with taxpayer awareness as a mediating variable. The analysis technique used is path analysis using SPSS software. The research population was individual taxpayers registered at North Badung KPP Pratama totaling 101,577 taxpayers and 100 people as a sample. The sampling method is using the nonprobability sampling method. Data collection method by distributing questionnaires to 100 individual taxpayers. The results of the study stated that knowledge of taxation had an effect on taxpayer awareness, taxpayer awareness had an effect on taxpayer compliance, and knowledge of taxation had had an effect on taxpayer compliance, while taxpayer awareness could not mediate the influence of tax knowledge on taxpayer compliance.
Keywords: Tax Knowledge; Taxpayer Compliance; Taxpayer Awareness.