bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the choice of surgical tactics in geriatric patients with benign prostatic hyperplasia
Authors: Leshchenko I. G. , Bratchikov O. I. , Akimov A. I. , Zhilyaeva Yu. A. 
Published: March 2023

Background. The analysis of modern scientific literature indicates that if the list of indications for elective surgery in geriatric patients with benign prostatic hyperplasia (BPH) meets the requirements of urological practice, then the contraindications for this operation clearly do not correspond to them.Aim. Based on the current list of contraindications to elective surgery in geriatric patients with BPH, to develop rational surgical tactics aimed at reducing the frequency and severity of postoperative complications and deaths.Materials and methods. Examination and treatment of 295 geriatric patients with stage 2 BPH (main group A) who underwent planned transurethral resection of the prostate or transpusical adenomectomy in the period from 2007 to 2015 at the Samara Regional Clinical Hospital of War Veterans (the clinical base of the First Research Institute of Clinical Gerontology and Rehabilitation of War Veterans of the Medical University “Reaviz”). During this period, 116 geriatric patients with stage 2 BPH (main group B) using the author’s list of contraindications, elective surgery was contraindicated. They underwent conservative treatment. The control group consisted of 344 geriatric patients with stage 2 BPH who underwent elective transurethral resection of the prostate or transpusical adenomectomy in the same Hospital from 2000 to 2006, taking into account the contraindications to these operations that existed at that time. The age of patients in all groups was from 60 to 89 years.Results. The use of this list made it possible to establish among 116 patients (main group B) excretory absolute contraindications to surgery were performed in 48.3 % of patients, relative present contraindications of the second – in 33.6 %, temporary contraindications of rendering – in 13.8 %, a special contraindication to transurethral resection of the prostate – in 1.7 %, special contraindications to transvesical adenomectomy – in 2.6 %, which contributed to the prevention of possible postoperative complications and deaths among them.Conclusion. The clinical expediency of using the author’s approach to the choice of surgical tactics, taking into account contraindications to elective surgery in geriatric patients of the main group A, compared with patients of the control group, consisted in reducing of postoperative complications and deaths and increasing of good immediate treatment results among them.
Relationship between seminal plasma cytokine levels and asthenozoospermia in infertile men
Authors: Muradian A. A. , Gamidov S. I. , Popova A. U. , Ovchinnikov R. I. , Shatylko T. V. 
Published: March 2023

Background. Violation of male fertility can have various causes, one of which is a decrease in sperm motility. In the pathogenesis of asthenozoospermia, some bioactive substances, in particular cytokines, may be involved.Aim. To estimate the number of the most studied cytokines to date in the ejaculate of infertile men with normozoospermia and patients with asthenozoospermia.Materials and methods. We examined 38 infertile patients with normozoospermia and 10 men with asthenozoospermia, comparable in age. All participants in the study were performed a spermogram and an analysis to determine the amount of the cytokines in seminal plasma, such as interleukins 1β, 2, 4–8, 10, 12, 13, 17, G-CSF, GM-CSF, interferon γ, MCP-1, MIP-1β and tumor necrosis factor α. Then, using nonparametric statistics, the relationship between the level of the above cytokines and the presence of asthenozoospermia was analyzed.Results. As a result, we were able to find out that there is a relationship between the concentration of interleukin 6, interleukin 8 and MIP-1β and sperm motility.Conclusion. Further research is needed to assess whether these bioactive inflammatory mediators have potential relevance for use as targets in the treatment of male infertility.
Microsurgical treatment of varicocele with intraoperative Doppler control (literature review)
Authors: Chernushenko A. S. , Akhvlediani N. D. , Reva I. A. , Pushkar D. Yu. 
Published: March 2023

Microsurgical subinguinal ligation of the veins of the spermatic cord (Marmara operation) is the “gold standard” treatment of varicocele. Currently, the use of an operating microscope and microsurgical instruments to perform this operation has proven its effectiveness. The question of the expediency of using intraoperative dopplerography remains a subject of discussion.The analysis of 23 articles using the MEDLINE database (PubMed) was carried out. The data on the efficacy and safety of microsurgical subinguinal correction of varicocele with and without intraoperative dopplerography are compared. The use of intraoperative dopplerography in microsurgical subinguinal correction of varicocele allows achieving the best treatment results.
Minimally invasive techniques of urethral stricture treatment and their use in patients of pediatric age (literature review)
Authors: Ladygina E. A. , Demin N. V. , Nikolayev V. V. , Faniev M. V. , Suleymanov S. I. 
Published: March 2023

Urethralstricture remains one of the most discussed problemsin pediatric urology. Despite a significant number of articles and the existence of a wide variety of methods for treating urethral strictures and their modifications, every new generation of urologists encounters this problem.Treatment of urethralstricture often takes a long time and requires multiple surgical interventions. Treatment techniques continuously improve, therefore it is appropriate to regularly summarize new data. Such methods as bougienage, balloon dilation and urethralstenting are still being used, although as early asin the beginning of the 19th century the first types of such modern method as optical internal urethrotomy were developed. In relation to optical internal urethrotomy, discussions on indications, techniques, duration of catheterization, necessity of combination with intermittent catheterization, use of hormonal drugs continue. The question of the number of attempts to perform urethrotomy also remains controversial.In this review, we tried to clarify the problem of use of minimally invasive techniques for urethral stricture treatment in children in the context of current scientific data and historical aspects.
Validation of a questionnaire on pelvic organ function for neurological patients in Russia
Authors: Korshunova E. S. , Yusupova D. G. , Zimin A. A. , Pyatnitskaya T. M. , Zaitsev A. B. , Yatsko K. A. , Polekhina N. V. , Belova N. V. , Korshunov M. N. , Korshunov D. M. , Darenkov S. P. , Suponeva N. A. , Sakakibara R. 
Published: March 2023

Background. Dysfunction of the bladder and intestinal tract, as well as sexual disorders, can be caused by pathologies of the pelvic organs themselves or changes in the control of these organs by the nervous system. Modern questionnaires are organ-specific and are intended for specific neurological disorders. Questionnaire on pelvic organ function is a valuable instrument for evaluation of complaints from neurological patients, therefore there is a necessity of creating an official adapted Russian version.Aim. Creation of a Russian-language version of the pelvic organ function questionnaire and its validation on a cohort of patients with neurological diseases.Materials and methods. Following international standards, validation of the questionnaire included linguistic and cultural adaptation and assessment of its psychometric properties. Approval of the Russian-language questionnaire version was obtained directly from the developer, Ryuji Sakakibara. The questionnaire was tested twice – before and after treatment. There were 48 patients over 18 years old (18 with Parkinson’s disease, 15 with multiple sclerosis, and 15 post-stroke).Results. The Median (IQR) age of patients was 56.5 (42–70.5) years. A Russian-language version of the questionnaire was developed during linguistic and cultural adaptation. This version of the questionnaire is posted in the text of this publication. It is also available on the website of the validation group of the international scales and questionnaires of the Research Center of Neurology. At the 2nd stage of validation, it was shown that the mean score in the sample was 2.03 ± 0.52 per question upon admission to the hospital and decreased significantly to 1.91 ± 0.51 per question on discharge (Wilcoxon test, p ˂ 0.0001). It confirms the questionnaire’s high sensitivity to changes in the clinical picture. Cronbach’s alpha coefficient was 0.82 (p ˂ 0.001).It indicates the high level of internal consistency of the questionnaire. Significant Spearman’s coefficients prove criterion validity of the studied questionnaire compared to the established questionnaires.Conclusion. This Russian-language version of the pelvic organ function questionnaire is a useful assessment tool for patients’ complaints and disease dynamics. This work is valuable as an example of adapting a foreign scale or questionnaire to the local health care system.
Anti-parietal cell antibody positivity in women with poor obstetric history and skin disorders: significance of preconception counseling
Authors: BEKSAC Burcu , DONMEZ Hanife Guler , CAGAN Murat , BEKSAC M.sinan 
Published: March 2023

Purpose: The aim of this study was vto demonstrate the impact of anti-parietal cell antibody (APCA) positivity in women with poor obstetric history and skin disorders.
Materials and Methods: This retrospective cohort consisted of 63 women having skin disorders and poor obstetric history. Patients were grouped into the control (women with skin disorders only, n=50) and study groups (women with skin disorders and APCA positivity, n=13). The study groups were compared in terms of demographic findings, BOI, and risk factors for placenta-related obstetric complications.
Results: APCA (+) and APCA (–) groups showed no statistically significant difference in terms of demographic findings such as age, gravidity, parity, BOI, and the number of miscarriages.. We have demonstrated that 69.2% (9/13) of the APCA (+) cases have two or more skin diseases, while 34% of APCA (-) women have multiple skin diseases. There was a statistically significant difference between APCA (+) and APCA (–) groups in terms of the presence of single or multiple skin diseases (p=0.029). We could not demonstrate a statistically significant difference between APCA (+) and APCA (–) patients in terms of the presence of risk factors for obstetric complications such as immune system problems, MTHFR polymorphisms, hereditary thrombophilia, and diabetes mellitus type-2.
Conclusion: APCA positivity which is a risk factor for obstetric complications might be a good indicator used to identify susceptibility to multiple skin disorders during preconception counseling.
Biosensor Elektrokimia untuk Memonitor Level Hemoglobin Terglikasi (HbA1c) pada Penyakit Diabetes Melitus
Authors: Destiani Sheila , Maksum Iman Permana , Hartati Yeni Wahyuni 
Published: March 2023

<p>Hiperglikemia merupakan ciri diabetes melitus, sekelompok penyakit metabolik yang disebabkan oleh kelainan sekresi insulin, kerja insulin, atau keduanya. Hiperglikemia dapat menyebabkan kerusakan jangka panjang, disfungsi, dan kegagalan berbagai organ, terutama jantung, mata, saraf, pembuluh darah, dan ginjal. Oleh karena itu, diagnosis dan pemantauan rutin kadar glukosa darah sangat penting dilakukan. Hemoglobin terglikasi (HbA1c) adalah hemoglobin yang berikatan dengan glukosa dalam darah dan ditetapkan menjadi biomarker hiperglikemia yang dapat mengindikasikan diabetes atau prediabetes. Akan tetapi, pengukuran HbA1c di laboratorium klinis membutuhkan instrumen yang canggih dan mahal, tenaga ahli khusus dan waktu lama. Oleh karena itu, biosensor elektrokimia kemudian mulai dikembangkan untuk mendeteksi kadar HbA1c karena mudah digunakan, hasil cepat, dan harga yang murah. Ulasan ini membahas biosensor elektrokimia untuk mendeteksi HbA1c dan metode imobilisasi bioreseptor.</p><p><strong>Electrochemical Biosensor for Monitoring Glycated Hemoglobin (HbA1c) Levels in Diabetes Mellitus. </strong>Hyperglycemia is a hallmark of diabetes mellitus, a group of metabolic diseases caused by defects in insulin action, insulin secretion, or both. Hyperglycemia can cause long-term damage, dysfunction, and failure of various organs, especially the heart, blood vessels, eyes, nerves, and kidneys.. Therefore, routine diagnosis and monitoring of blood glucose levels are very important. Glycated hemoglobin (HbA1c) is hemoglobin that binds to glucose in the blood and is established as a biomarker of hyperglycemia that may indicate diabetes or prediabetes. However, measurement of HbA1c in the clinical laboratory requires large and expensive instruments, specialized experts, and takes a long time. Therefore, an electrochemical biosensor began to be developed to detect HbA1c levels because it is easy to use and has fast results at lower prices. This review discusses electrochemical biosensors for detecting HbA1c and the immobilization of bioreceptors. </p>
Curing Sand Production Problems with an Aqueous-Based Resin Sand Consolidation Treatment to Optimize the Hydrocarbon Recovery Factor in Austrian Gas Fields
Authors: Trujillo Erika Johana Tovar , Santin Yoann , Ukoha Obinnaya , Maier Robert , Kiss Akos , Moertl Monika , Zabel David 
Published: March 2023

AbstractUnconsolidated fine formation sand in mature Austrian gas fields jeopardizes production rates and well productivity as increasing water cut enhances fines and sand production to the well bore. The wells peak production was years ago, making well intervention challenging to stay within tight economic limits. Stabilizing the formation rock with aqueous-based resin eliminated sand production and reduced intervention costs to restore target rates.To remain within economical budget levels for the projects, engineering-focused its research on treatments that can be applied rig-less and are suitable for the Austrian gas field reservoir parameters with moderately low temperatures, reasonable interval length, depleted reservoir pressure, and dis-stacked perforations.Team collaboration resulted in proposing a rock consolidation treatment with an Internally Catalyzed Aqueous-Based Emulsion of Curable Epoxy Resin (ICABECER). Thorough planning and pre-job lab testing reduced operational risks, saved costs, and optimized outcomes.The placement technique and displacement precautions resulted in reservoir rock without notable flow path reduction, allowing quickly anticipated target rates to be reached. The treatment outcome confirmed laboratory testing where rock permeability was retained, and only small amounts of residue sand were produced during the cleanup period. The intervention's simplicity allowed using standard field equipment, minimizing cost, and calculating a business case according to tight budgetary constraints.The wells, scheduled for plug and abandon because of pretreatment sand production, demonstrated a stable gas flow with reduced sand content enabling economic gas production. During the cleanup period, sufficient sand was produced to erode surface equipment; however, after the start-up period, sand production was reduced to zero, and the well was returned to the target rate.The technical simplicity of the chemical treatment and a collaboratively engineered and optimized application open new opportunities for the asset to reduce or eliminate sand production without the need for expensive sand control installations at the sand face. Furthermore, the chemical reservoir rock stabilization prolongs well life and increases the overall recovery factor. Reducing environmental impact is also key for resource-saving and sustainable operations in mature fields.
Optimal Financing Decision with Financial Constraints for a Manufacturer in a Low-Carbon Supply Chain
Authors: zong shengliang , Huang Ning 
Published: March 2023

Abstract
In this paper, bank financing (BF) and trade credit financing (TCF) are viable. We investigate the financing choice problem for an emission-dependent manufacturer with capital constrained. And the members of the supply chain each pursue their profit maximization. In the existing literature on the financing supply chain, enterprises and consumers are becoming more and more aware of environmental protection. A growing number of manufacturers produce low-carbon products like environment-friendly bags through a green supply chain system. We use the Stackelberg game to study the equilibrium financing choice and optimal decisions. We also perform numerical analysis to verify the impact of certain parameters on financing decisions. The results show that no direct relationship between the degree of carbon reduction and the total amount of carbon emissions as defined by the government. Besides, when the trade credit interest rate is higher than the bank interest rate, the manufacturer will choose bank financing. When the credit interest rate is lower than a certain threshold, the retailer provides trade credit financing. Our study also provides useful insights for managers to understand and make financing decisions in the low-carbon supply chain with the capital-constrained manufacturer.
The feasibility of self-performing measurements of peripheral oxygen saturation and respiratory exercises in home-isolated COVID-19 patients
Authors: Myklebust-Hansen Hans Joakim , Hasvik Eivind , Ghanima Waleed , Solyga Volker 
Published: March 2023

Abstract
Background: COVID-19 is a highly contagious disease where isolation of infected individuals is deemed warranted. If possible, home-isolation is preferred over hospitalization. This implies a need for methods of observation that can ensure the safety of these patients. Preventive treatment methods that can both decrease the probability for development of critical disease and hopefully decrease the need for hospitalization would be an added benefit. This was a pilot study performed to assess the feasibility of performing self-measurements of SpO2 and respiratory exercises in at-home isolated COVID-19 patients.
Method: 40 SARS-CoV-2 positive individuals in home-isolation were included for a follow-up time of 14 days. At baseline, they were equipped with a pulse oximeter, PEF meter, a project diary to note all measurements, and simple instructions on how to perform respiratory exercises. No other contact was made, but participants were instructed to contact the hospital based on given criteria for blood oxygenation levels and dyspnea severity and to return study equipment and the project diary at the end of study.
Results: 35 participants completed daily SpO2 measurements during the follow-up period and 12 performed daily respiratory exercises as instructed. Four participants were admitted to hospital during the follow-up period. Five participants terminated follow-up prematurely.
Conclusions: Performing self-measurements of SpO2 during home isolation due to COVID-19 infection is feasible. The feasibility of performing respiratory physiotherapy in ambulant patients is questionable and may require more motivational interventions to increase adherence.
Trial registration: ClinicalTrials.gov Identifier: NCT04647747
Soft K−Proximity Spaces
Authors: El-Sheikh S. A. , Kandil S. A. , Hussien S 
Published: March 2023

Abstract
This study expands the idea of a K−proximity relation and its characteristics to a soft K−proximity by creating various forms of it from a soft K−proximity. Additionally, it investigates the properties of a soft K−proximity neighborhood, soft K−proximity mappings, and the product of soft K−proximity spaces.
ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis
Authors: Körner Lioba , Wachsmuth Laurens , Kumari Snehlata , Schwarzwer Robin , Jiao Huipeng , Pasparakis Manolis 
Published: March 2023

Abstract

Z-DNA binding protein 1 (ZBP1) has important functions in anti-viral immunity and in the regulation of inflammatory responses. ZBP1 induces necroptosis by directly engaging and activating RIPK3, however, the mechanisms by which ZBP1 induces inflammation and in particular the role of RIPK1 and the contribution of cell death-independent signaling remain elusive. Here we show that ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1-caspase-8-mediated apoptosis. ZBP1 induced TNFR1-independent skin inflammation in mice with epidermis-specific ablation of FADD by triggering keratinocyte necroptosis. Moreover, transgenic expression of C-terminally truncated constitutively active ZBP1 (ZBP1ca) in mouse epidermis caused skin inflammation that was only partially inhibited by abrogation of RIPK3-MLKL-dependent necroptosis and fully prevented by combined deficiency in MLKL and caspase-8. Importantly, ZBP1ca induced caspase-8-mediated skin inflammation by RHIM-dependent but kinase activity-independent RIPK1 signaling. Furthermore, ZBP1ca-induced inflammatory cytokine production in the skin was completely prevented by combined inhibition of apoptosis and necroptosis arguing against a cell death-independent pro-inflammatory function of ZBP1. Collectively, these results showed that ZBP1 induces inflammation by activating necroptosis and RIPK1 kinase activity-independent apoptosis.
XJDHT protects against sepsis-induced cardiac inflammation and apoptosis via suppression TLR4/NF-κB and activating PI3K/AKT pathway
Authors: shen zhiqing , Lin Mingrui , Li Jiapeng , Ding Qihang , Liu Huixin , Chen Xiaoling , Chen Huaiyu , Zhu Xueli , Li Wei 
Published: March 2023

Abstract
Purpose
Xijiao Dihuang decoction (XJDHT), a traditional Chinese medicine, is widely used to treat patients with sepsis. However, the mechanisms underlying the effects of XJDHT on cardiac dysfunctionhave yet to be fully elucidated. The present study evaluated the potential utility of XJDHT in protecting against sepsis-induced cardiac dysfunction and myocardial injury.
Methods
Mice administered Lipopolysaccharide (LPS,10 mg/kg) or equivalent saline solution (control) were treated with XJDHT (10 g/kg/day) or saline by gavage for 72 hours.
Results
Treatment with XJDHT significantly enhanced myocardial function and attenuated pathological change, infiltration of inflammatory cells, levels of TNF-α,IL-1β and expression of TLR4 and NF-κB in mice with sepsis. RNA sequencing and Kyoto Encyclopedia of Genes and Genomes pathway analyses identified 531 differentially expressed genes and multiple enriched signaling pathways including the PI3K/AKT pathway. Further, XJDHT attenuated cardiac apoptosis and decreased Bax protein expression while increasing protein levels of Bcl-2, PI3K, and p-AKT in cardiac tissues of mice with sepsis.
Conclusion
In summary, XJDHT improves cardiac function in a murine model of sepsis by attenuating cardiac inflammation and apoptosis via suppression the TLR4/NF-κB pathway and activating the PI3K/AKT pathway