bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Milan affect management? A retrospective analysis of resection rate and time to surgery among Milan categories
Authors: Tenney Troy B. , Mullane Patrick C. , Viswanathan Kartik , Shi Qiuying , Lui Shu K. , Lubin Daniel J. 
Published: January 2023

AbstractIntroductionThe Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is an established system with reproducible risk of malignancies (ROM) for salivary gland fine needle aspiration (SGFNA). No studies have reviewed the relationship between Milan categories and the resection rate (RR) and time to resection (TTR).MethodsWe searched our database (January 1, 2011 to January 4, 2021) for non‐lymphoma SGFNAs and assigned appropriate MSRSGC categories. RR and TTR were calculated and compared for each category. A literature search was performed; RRs and TTRs were compared.ResultsSeven hundred and eighty SGFNAs were identified, 333 with follow‐up. RR was highest in suspicious for malignancy (SUS, V; 70.6%, n = 12/17), followed by the salivary gland neoplasm of uncertain malignant potential (SUMP, IVb; 69.6%, n = 80/115) and malignant (M, VI; 55.6%, n = 75/135). Among M, primary tumors had a higher RR (65.1%, n = 41/63) than metastases (47.2%, n = 34/72, p = .36). In literature review, SUS had the highest RR (69.3%, n = 233/336) followed by M (61.6%, n = 821/1332) and SUMP (60.2%, n = 632/1050). TTR was shorter in SUS (mean = 32.3 days, median = 25 days). Within the benign neoplasms (BN, IVa), Pleomorphic adenomas (PAs) had a higher RR than Warthin tumors (WTs) (66.3% vs. 37.2%, p < .00001), and a shorter TTR (median = 63 days vs. 90 days).ConclusionsTumors classified as SUS had higher RR and at shorter intervals than those classified as SUMP. PAs have higher RRs and more expedient surgery than WTs. Cases classified as M are less likely to undergo follow‐up than SUS, perhaps due to a lower RR for metastases.
Metabolites identification of anabolic steroid bolasterone in vitro and in rats by high resolution liquid chromatography mass spectrometry
Authors: Muresan Anca Raluca , Rahaman Khandoker Asiqur , Son Junghyun , Kang Min‐Jung , Kwon Oh‐Seung 
Published: January 2023

AbstractBolasterone (7α,17α–dimethyltestosterone) and anabolic androgenic steroids are included in the World Anti‐Doping Agency's Prohibited list of substances. This study aimed to evaluate the metabolism of bolasterone through in vitro experiments using rat liver microsomes and in vivo experiments using rat urine after oral administration. Urine samples were collected over a 168‐h period. Bolasterone and its metabolites were detected by liquid chromatography coupled with a Q‐Exactive Obitrap mass spectrometry (LC‐HRMS). Ultimately 16 hydroxylated metabolites (M1–M16), one metabolite from the reduction of the 3‐keto function and 4‐ene (M17), and one glucuronic acid conjugated metabolite (M18) were detected. Metabolites M17 and M18 were confirmed by comparison with available reference or authentic standards. Metabolic modifications in the structure of the parent bolasterone result in different fragmentation patterns. Based on the sensitivity of the HRMS data, characteristic ions such as m/z 121.064 (C8H9O) generated from ring A of the mono‐hydroxylated metabolites and 121.101 (C9H13) generated from ring D of the di‐hydroxylated metabolites were observed that helped differentiate between the obtained metabolites. The structures of fragment ions were tentatively proposed based on their fragmentation pathways, where the significant ions were correlated to the possible structural fragments. In conclusion, new metabolites of bolasterone were detected and characterized by the use of the full‐scan and dd‐MS/MS using LC‐HRMS, and this data can be useful for providing metabolite information for the interpretation of mass spectra of anabolic bolasterone analogues for doping screening tests.
Simultaneous voltammetric determination of acetylsalicylic acid, caffeine and paracetamol in pharmaceutical formulations using screen‐printed carbon electrode
Authors: Cortés Karla , Triviño Juan José , Arancibia Verónica 
Published: January 2023

AbstractElectrochemical oxidation of Paracetamol (PAR), Acetylsalicylic acid (ASA) and Caffeine (CAF) was investigated employing square wave stripping voltammetry (SWSV) using screen–printed carbon electrodes (SPCE). Determinations were performed in 0.1 mol L−1 BR buffer (pH 2.0) without accumulation step. SWV were obtained by scanning the potential from 0.00 to 1.40 V employing a scan increment of 4 mV, pulse amplitude 25 mV and frequency of 25 Hz. PAR, ASA and CAF presents oxidation signals at 0.45, 1.03 and 1.32 V. The detection limits were 1.2, 1.7 and 1.7 mg L−1, respectively. The method was applied in the PAR‐ASA‐CAF determination on pharmaceutical formulations.
Electrophoresis of a small sphere in a cylinder of finite length
Authors: Sherwood John D. 
Published: January 2023

AbstractThe pressure due to electrophoretic motion of a charged colloidal sphere in a fluid‐filled circular cylinder is determined in the limit in which the sphere radius is small compared with that of the cylinder. If the ends of the cylinder are open, pressure‐driven Poiseuille flow occurs, but the magnitude of this flow is shown to be small when the cylinder is long compared to its radius. It is concluded that the flow has little effect upon electrophoretic velocities, unlike when the diameter of the sphere is comparable to that of the cylinder in which case the Poiseuille flow increases electrophoretic velocities and creates long‐range interactions between spheres.
Study of effect modifiers of genetically predicted CETP reduction
Authors: Legault Marc‐André , Barhdadi Amina , Gamache Isabel , Lemaçon Audrey , Lemieux Perreault Louis‐Philippe , Grenier Jean‐Christophe , Sylvestre Marie‐Pierre , Hussin Julie G. , Rhainds David , Tardif Jean‐Claude , Dubé Marie‐Pierre 
Published: January 2023

AbstractGenetic variants in drug targets can be used to predict the long‐term, on‐target effect of drugs. Here, we extend this principle to assess how sex and body mass index may modify the effect of genetically predicted lower CETP levels on biomarkers and cardiovascular outcomes. We found sex and body mass index (BMI) to be modifiers of the association between genetically predicted lower CETP and lipid biomarkers in UK Biobank participants. Female sex and lower BMI were associated with higher high‐density lipoprotein cholesterol and lower low‐density lipoprotein cholesterol for the same genetically predicted reduction in CETP concentration. We found that sex also modulated the effect of genetically lower CETP on cholesterol efflux capacity in samples from the Montreal Heart Institute Biobank. However, these modifying effects did not extend to sex differences in cardiovascular outcomes in our data. Our results provide insight into the clinical effects of CETP inhibitors in the presence of effect modification based on genetic data. The approach can support precision medicine applications and help assess the external validity of clinical trials.
Higher clearance rates of multiple HPV infections may explain their lower risk of HSIL: A retrospective study in Wenzhou, China
Authors: Ni Xinyu , Hu Jiaming , Huang Yin , Tao Jinxin , Zhu Hua 
Published: January 2023

AbstractPersistent human papilloma virus (HPV) infection is known to be associated with cervical lesions. The chief object of the study is to investigate if the pathogenicity of multiple HPV infections is different from a single infection. Furthermore, we would like to corroborate the discrepancy with clearance rates. Between August 1, 2020, and September 31, 2021, 5089 women underwent a colposcopy‐directed biopsy in our hospital. We divided the 2999 patients who met the criteria into multiple and single HPV infection groups. The HPV genotypes were identified using the flow cytometry fluorescence hybridization technology. Binary logistic regression and survival analysis were used to perform statistics. Among HPV‐positive individuals, 34.78% (1043/2999) were positive for 2 or more HPV types. After adjusting for the main factors, compared with single infection, multiple infections were associated with a significantly decreased risk of high squamous intraepithelial lesions (HSIL) (odds ratio [OR]: 0.570; 95% confidence interval [CI]: 0.468–0.694). In the mean time, the clearance rates of multiple infections were significantly higher (OR: 2.240; 95% CI: 1.919–2.614). When analyzing specific types covered by the 9‐valent HPV vaccine, consistency between the lower risk of HSIL and the higher clearance rate was found in the most groups. Compared with a single infection, multiple HPV infections have a lower risk of HSIL, which may be related to its higher clearance rate. It suggests that aggressive treatment of multiple HPV infections early in their detection may be beneficial.
Molecular characterization of rotavirus infections in children less than 5 years of age with acute gastroenteritis in Tehran, Iran, 2021–2022: Emergence of uncommon G9P[4] and G9P[8] rotavirus strains
Authors: Kachooei Atefeh , Tava Koli Ahmad , Minaeian Sara , Hosseini Mahdieh , Jalilvand Somayeh , Latifi Tayebeh , Arashkia Arash , Ataei‐Pirkooh Angila , Shoja Zabihollah 
Published: January 2023

AbstractThe present study was conducted to monitor the genotypes of circulating species A rotavirus (RVA) in Iran and investigate genetic linkages between specific RVA VP7, VP4, VP6, and NSP4 segments. For this purpose, 48 RVA strains were detected during the 2021–2022 seasons. The two combinations of G9P[4] and G9P[8] RVA strains were predominant. However, several other combinations of RVA also were detected. Based on the distribution of I and E genotypes (46 strains) with respect to G and P, the most common strains were G9P[4]‐I2‐E2 (19.5%), G9P[4]‐I2‐E1 (6.5%), G9P[4]‐I1‐E1 (4.3%), G9P[8]‐I1‐E1 (19.5%), and G9P[8]‐I2‐E2 (10.9%), which were followed by several other combinations of G and P RVA strains with different pattern of I‐E genotypes and also emerging, rare and uncommon strains. The present study described the continued circulation of G9 strains with the emergence of uncommon G9P[4] and G9P[8] reassortants with three and two different I‐E genotypes, respectively, which have not been reported previously in Iran. Our findings indicated that these uncommon strains exhibited a unique genotype pattern comprising a mixture of genogroup 1 and 2 genes and suggest the need for further analysis of rare, uncommon, and emerging strains of RVA at all 11 gene segments to determine intergenogroup and intragenotype reassortments.
Inhibition of benzo[a]pyrene formation in charcoal‐grilled pork sausages by ginger and its key compounds
Authors: Zhang Xiaomin , Hu Gaofeng , Xu Chaoyang , Nie Wen , Cai Kezhou , Fang Hongmei , Xu Baocai 
Published: January 2023

AbstractBACKGROUNDGinger and its extracts have been frequently used in food processing and pharmaceuticals. However, the influence of ginger and its key compounds on benzo[a]pyrene (BaP) production in meat processing has not been investigated. The purpose of this study was to explore the effect of application of ginger and its important active ingredients on BaP formation and the mechanism of inhibiting BaP formation in charcoal‐grilled pork sausages.RESULTSThe DPPH scavenging (23.59–59.67%) activity and the inhibition rate of BaP (42.1–68.9%) were significantly increased (P < 0.05) with increasing ginger addition. The active components extracted by supercritical carbon dioxide from ginger were identified by gas chromatography–mass spectrometry and 14 representative compounds (four terpenes, two alcohols, two aldehydes, four phenols and two other compounds, totaling 77.57% of the detected compounds) were selected. The phenolic compounds (eugenol, 6‐gingerol, 6‐paradol and 6‐shogaol, accounting for 29.73% of the total composition) in ginger played a key role and had the strongest inhibitory effect on BaP (61.2–68.2%), whereas four other kinds of compound showed obviously feeble inhibitory activity (6.47–17.9%). Charcoal‐grilled sausages with phenolic substances had lower values of thiobarbituric acid‐reactive substances, carbonyl and diene (three classic indicators of lipid oxidation) (P < 0.05).CONCLUSIONGinger and its key compounds could effectively inhibit the formation of BaP in charcoal‐grilled pork sausages. Phenolic compounds make the strongest contribution to the inhibition of Bap formation, and the inhibitory mechanism was related to the inhibition of lipid oxidation. © 2023 Society of Chemical Industry.
Cancer risk‐reducing surgery: Brazilian Society of Surgical Oncology Guideline Part 2 (Gastrointestinal and thyroid)
Authors: Carneiro Vandré C. G. , Gifoni Ana C. L. V. C. , Rossi Benedito M. , da Cunha Andrade Carlos E. M. , de Lima Fernanda T. , de Campos Reis Galvão Henrique , da Rocha Jose C. C. , da Silva Barreto Leonardo S. , Ashton‐Prolla Patrícia , Guindalini Rodrigo S. C. , de Farias Terence P. , Andrade Wesley P. , de Sousa Fernandes Paulo H. , Ribeiro Reitan , Lopes Andre , Tsunoda Audrey T. , Azevedo Bruno R. B. , Marins Carlos A. M. , de Albuquerque Oliveira Uchôa Diego N. , Dos Santos Evandro A. S. , Coimbra Felipe J. F. , Filho Francisco A. D. , de Oliveira Lopes Francisco C. , Fernandes Francisco G. , Ritt Guilherme F. , Laporte Gustavo A. , Guimaraes Gustavo C. , Feitosa e Castro Neto Heládio , dos Santos Jocela C. , de Carvalho Vilela Jordana B. , Junior Jorge G. M. , da Cunha Juliano R. , Milhomem Leonardo M. , da Silva Luciana M. , de Freitas Maciel Luiza , Ramalho Nathalia M. , Nunes Rafael L. , de Araújo Rodrigo G. , de Assunção Ehrhardt Rogério , Bocanegra Ronald E. D. , Junior Tyrone C. S. , de Oliveira Viviane R. , Surimã Walyson S. , de Melo Melquiades Miriam , de Castro Ribeiro Heber S. , Oliveira Alexandre F. 
Published: January 2023

AbstractBackgroundRisk‐reducing operations are an important part of the management of hereditary predisposition to cancer. In selected cases, they can considerably reduce the morbidity and mortality associated with cancer in this population.ObjectivesThe Brazilian Society of Surgical Oncology (BSSO) developed this guideline to establish national benchmarks for cancer risk‐reducing operations.MethodsThe guideline was prepared from May to December 2021 by a multidisciplinary team of experts to discuss the surgical management of cancer predisposition syndromes. Eleven questions were defined and assigned to expert groups that reviewed the literature and drafted preliminary recommendations. Following a review by the coordinators and a second review by all participants, the groups made final adjustments, classified the level of evidence, and voted on the recommendations.ResultsFor all questions including risk‐reducing colectomy, gastrectomy, and thyroidectomy, a major agreement was achieved by the participants, always using accessible alternatives.ConclusionThis and its accompanying article represent the first guideline in cancer risk reduction surgery developed by the BSSO and it should serve as an important reference for the management of families with cancer predisposition.
Is early extubation after esophagectomy safe? A systematic review and meta‐analysis
Authors: Serafim Maria Carolina Andrade , Orlandini Marina Feliciano , Datrino Letícia Nogueira , Tavares Guilherme , Tristão Luca Schiliró , dos Santos Clara Lucato , Pinheiro Filho João Emílio Lemos , Bernardo Wanderley Marques , Tustumi Francisco 
Published: January 2023

AbstractThere is no consensus on the timing of extubation after esophagectomy. There is a fear that premature extubation may result in a high risk of urgent reintubation. On the other hand, there is a risk of lung damage in prolonged intubation. The present systematic review compares early and late extubation. Five articles were selected. Early extubation after esophagectomy does not increase the risk of reintubation, mortality, complications, and length of stay.
Gastric cancer with microsatellite instability displays increased thymidylate synthase expression
Authors: Pereira Marina A. , Dias André R. , Ramos Marcus F. K. P. , Cardili Leonardo , Moraes Rafael D. R. , Zilberstein Bruno , Nahas Sergio C. , Mello Evandro S. , Ribeiro Ulysses 
Published: January 2023

AbstractBackgroundGastric cancer (GC) with microsatellite instability (MSI) is a less aggressive disease and associated with resistance to 5‐fluorouracil (5‐FU)‐based chemotherapy (CMT). Thymidylate synthase (TS) is inhibited by 5‐FU, and another potential mediator of therapeutic resistance to 5‐FU. Therefore, we aimed to analyze the association between MSI and TS expression in GC, and its impact on disease outcomes.MethodsWe retrospectively evaluated GC who underwent D2‐gastrectomy. MSI and TS were analyzed by immunohistochemistry. We also investigated p53 expression, PD‐L1 status, and tumor‐infiltrating lymphocytes (CD4 and CD8).ResultsOut of 284 GC, 60 (21.1%) were MSI. Median TS‐score for all cases was 16.5. TS expression was significantly higher in MSI compared to microsatellite‐stable (MSS; p < 0.001). Considering both status, GC were classified in four groups: 167 (58.8%) MSS + TS‐low; 57 (20.1%) MSS + TS‐High; 24 (8.5%) MSI + TS‐low; and 36 (12.7%) MSI + TS‐high. MSI + TS‐high group had less advanced pTNM stage, higher CD8+T cells levels (p < 0.001) and PD‐L1 positivity (p < 0.001). Normal p53 expression was related to MSI GC (p < 0.001). Improved survival was observed in MSI + TS‐high, but no survival benefit was seen with CMT.ConclusionMSI GC was associated with high TS levels, which may explain therapeutic resistance to 5‐FU. Additionally, MSI + TS‐high showed better survival, but without improvement with CMT.
High soluble OX40 levels correlate with metastatic gastric cancer
Authors: Lima Cecilia A. C. , Martins Mário R. , dos Santos Rogerio L. , da Silva Luciana M. , Silva Jeronimo P. A. , Torres Leuridan C. , Forones Nora M. 
Published: January 2023

AbstractBackground and ObjectivesPrevious studies demonstrated an association between OX40+T cell expression with poor prognosis in gastric cancer (GC). The soluble form of OX40 (sOX40) could block the interactions between OX40 on the effector T cell, and it is a ligand (OX40L) in dendritic cells. However, the role of sOX40 as a pretreating biomarker and prognostic predictor remains unclear. This study aimed to evaluate the association of levels of sOX40 and sOX40L with disease progression in GC.MethodsBetween 2017 and 2018, a cross‐sectional study was performed on 83 GC patients and 20 healthy controls.ResultsAmong 83 GC patients (median of 63 years), 32.4% of patients with I/II stages, 42.3% III, and 25.3% in IV stages. Metastatic GC patients had significantly higher levels of soluble OX40 compared with stage III (p = 0.0003) and early stages I and II patients (p = 0.005). There was no significant differences in the sOX40 and sOX40L levels between Lauren's histological subtype (intestinal, diffuse, and mixed).ConclusionsThis study showed that soluble OX40 levels have an essential role in GC progression. OX40 molecules may constitute a predictor for poor prognosis and a potential target for immunotherapy in GC.
Two‐ versus three‐field lymphadenectomy for esophageal cancer. A systematic review and meta‐analysis of early and late results
Authors: Datrino Letícia Nogueira , Orlandini Marina Feliciano , Serafim Maria Carolina Andrade , dos Santos Clara Lucato , Modesto Victoria Andrade , Tavares Guilherme , Tristão Luca Schiliró , Bernardo Wanderley M. , Tustumi Francisco 
Published: January 2023

AbstractThis study aims to estimate whether prophylactic cervical lymphadenectomy for esophageal cancer influences the short‐ and long‐term results through a systematic literature review and meta‐analysis. Twenty‐eight articles were selected in this systematic review, encompassing 9180 patients. Prophylactic neck lymphadenectomy for esophageal cancer should be performed with caution, as it is associated with worse short‐term results compared to traditional two‐field lymphadenectomy and does not improve long‐term survival.
Brazilian Society of Surgical Oncology surgical standards for resectable colorectal cancer liver metastases
Authors: Vaz da Silva Diego G. , Bredt Luis C. , Diniz Alessandro L. , Vieira Victor H. R. , Fernandes Paulo H. S. , Ribeiro Reitan , Ribeiro Héber S. C. , Oliveira Alexandre F. 
Published: January 2023

AbstractThe management of colorectal cancer liver metastasis (CRLM) has become complex because of the increasing availability of medical, radiological, and surgical treatment options applied either alone or in combination. However, resection remains the only evidence‐based curative therapy. These Brazilian Society of Surgical Oncology surgical standards are intended to guide clinicians in the decision‐making process for modern surgical management of CRLM within a multidisciplinary team in an evidence‐based framework, focusing on resectable disease.
Surgical management of locally advanced breast cancer: Recommendations of the Brazilian Society of Surgical Oncology
Authors: da Costa Vieira René A. , Andrade Wesley P. , Vieira Sabas C. , Romano Mauricio , Iglesias Gustavo , Oliveira Alexandre F. 
Published: January 2023

AbstractThe Brazilian Society of Surgical Oncology organized a group of oncological surgeons to discuss surgical aspects associated with locally advanced breast carcinoma. This article reviews the indications, different surgeries (thoracoabdominal or myocutaneous flaps), and associated complications. It discusses special conditions such as invasion of the chest wall and interscapular thoracic disarticulation. It makes recommendations based on the literature regarding clinical findings, tumor conditions, response to neoadjuvant therapy, choice of flaps in surgery, and tumor biology.
Surgery or active surveillance for pNETs < 2 cm: Preliminary results from a single center Brazilian cohort
Authors: Arra Dante A. S. M. , Ribeiro Heber S. C. , Henklain Gustavo , Barbosa Alex , Torres Silvio M. , Diniz Alessandro L. , Godoy André L. , Farias Igor C. , Costa Wilson L. , Coimbra Felipe J. F. 
Published: January 2023

AbstractBackground and ObjectivesIncidence of pancreatic neuroendocrine tumors (pNETS) seems to be rising over the years, with many cases incidentally diagnosed. Surgery and active surveillance are current treatment modalities for small pNETS. We review our institutional series and compare outcomes for small asymptomatic and nonfunctioning tumors.MethodsThis retrospective cohort study included patients with 2 cm or less and well differentiated pNETS at a single Brazilian Cancer Center. From 2002 to 2020, patients received active surveillance or surgery as a treatment strategy. Short and long‐term results were compared.ResultsSixty‐four patients were included, 41 in surgical strategy and 23 in the active surveillance approach. Baseline group characteristics were comparable. More patients on active surveillance underwent abdominal magnetic resonance imaging (MRI) and had tumors located in the pancreatic head (41% vs. 17%, p = 0.038). Minimally invasive procedure was chosen in 80.1% of the surgical patients. No patient died after surgery. Median follow‐up period was 38.6 and 46.4 months for active surveillance and surgery cohorts, respectively. No difference in disease progression rate was observed.ConclusionBoth approaches seem to be safe for small pNETs. Long‐term outcome and quality of life should be considered when discussing such options with patients.