bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant chemotherapy does not improve outcome in children with ovarian immature teratoma: A comparative analysis of clinical trial data from the Malignant Germ Cell International Consortium
Authors: Vieira Ana Glenda Santarosa , Puthenpura Vidya , Krailo Mark , Fallahazad Negar , Brougham Mark F. H. , Murray Matthew J. , Frazier A. Lindsay , Lopes Luiz Fernando , Pashankar Farzana 
Published: May 2023

AbstractBackground/objectivesSurgery is the mainstay of therapy for children with ovarian immature teratoma (IT), whereas adults receive adjuvant chemotherapy, except those with stage‐I, grade‐1 disease. In Brazil, children with metastatic ovarian IT received postoperative chemotherapy. This practice variation allowed evaluation of the value of chemotherapy, by comparison of Brazilian patients with those in the United States and United Kingdom.Design/methodsFrom the Malignant Germ Cell International Consortium data commons, data on ovarian IT patients from two recently added Brazilian trials (TCG‐99/TCG‐2008) were compared with data from US/UK (INT‐0106/GC‐2) trials. Primary outcome measure was event‐free (EFS) and overall survival (OS).ResultsForty‐two Brazilian patients were included (stage I: 27, stage II: 4, stage III: 8, stage IV: 3). Twenty‐nine patients had surgery alone, whereas 13 patients received postoperative chemotherapy. The EFS and OS for entire cohort was 0.80 (95% CI: 0.64–0.89) and 0.97 (0.84–0.99). There was no difference in relapse risk based on stage, grade, or receipt of chemotherapy. Comparing the Brazilian cohort with 98 patients in US/UK cohort (stage I: 59, stage II: 12, stage III: 27), there was no difference in EFS and OS across all stages, despite 87% of stage II–IV Brazilian patients receiving postoperative chemotherapy compared with only 13% of US/UK patients. The EFS and OS for Brazilian compared with US/UK cohort was stage I: 88% versus 98% (p = .05), stage II–IV EFS: 67% versus 79% (p = .32), stage II–IV OS: 93% versus 97% (p = .44); amongst grade‐3 patients, there was no difference in EFS or OS.ConclusionAddition of postoperative chemotherapy did not improve outcome in children with ovarian IT, even at higher grade or stage, compared with surgery alone.
Viral‐specific T cells for Cytomegalovirus retinitis following hematopoietic stem cell transplantation: A success story
Authors: Montiel‐Esparza Raul , Michalak Suzanne M. , Le Anthony Huy Dinh , Or Christopher , Nguyen Quan Dong , Khoury Ruby , Grimley Michael S. , Bertaina Alice , Klinger Edna , Shah Ami J. , Wood Edward H. 
Published: May 2023

AbstractCytomegalovirus retinitis (CMVR) following hematopoietic stem cell transplantation (HCT) for a primary immunodeficiency is a rare but highly morbid condition with potential irreversible consequences despite optimal antiviral pharmacotherapy. Viral‐specific T cells (VSTs) pose a promising and safe approach eradicating intractable viral disease. We describe the case of a 21‐month‐old male with Wiskott–Aldrich syndrome (WAS) and CMVR post HCT with sustained long‐term virologic and clinical response after CMV‐specific T‐cell therapy. This case highlights the need to consider VST as an adjunct upfront strategy in refractory CMVR and for routine ophthalmologic screening and surveillance in high‐risk patients post HCT.
Ganglioneuroblastoma intermixed: Clinicopathological implications of diagnosis at presentation and genomic correlations
Authors: Nezami Behtash G. , Modak Shakeel , Cardenas Fiorella Iglesias , Sarungbam Judy , Sirintrapun Sahussapont J. , Gopalan Anuradha , Chen Yingbei , Al‐Ahmadie Hikmat , Fine Samson W. , Reuter Victor E. , Tickoo Satish K. 
Published: May 2023

AbstractBackgroundGanglioneuroblastoma intermixed (GNBI) is classified as “favorable” histology by International Neuroblastoma Pathology Classification system. However, the International Neuroblastoma Risk Group (INRG) stratifies patients using wider clinicopathological and cytogenetic/molecular parameters. While the diagnosis of GNBI is typically made on resected tumor, it may sometimes be rendered on initial biopsy. We studied GNBI noted at diagnosis to evaluate its correlation with INRG staging and other clinicopathological and molecular features.MethodsIn this retrospective study, clinical, radiological, pathological, cytogenetic, and molecular information from patients with GNBI at diagnosis seen between 1995 and 2021 was analyzed. INRG staging was performed.ResultsOf the 15,827 neuroblastoma specimens, GNBI was noted in 237 patients. Of these, 53 had the initial pathological diagnosis of GNBI; median follow‐up 3.5 (range: 0.2–14) years. Disease was locoregional in 41 (77%, 16 stage L1 and 25 L2); none relapsed. Twelve (23%) had metastatic disease at presentation; six (50%) relapsed, and two died of disease. MYCN was amplified in two metastatic tumors. Six of 31 (19%) tumors tested had recurrent cytogenetic abnormalities and nonrecurrent somatic gene mutations in 10/23 (43%). The presence of any adverse molecular/cytogenetic findings was associated with metastatic disease (p < .05). For patients with localized GNBI undergoing both biopsy and resection, GNBI was diagnosed in both in 17/19 (90%).ConclusionsLocalized GNBI at diagnosis has excellent long‐term clinical outcome even without cytotoxic therapy. For localized GNBI, a biopsy sample is adequate to make the diagnosis. When associated with metastasis at diagnosis, prognosis is poorer, possibly due to associated adverse biological features.
Diminished ovarian reserve in adolescent cancer survivors treated with heavy metal chemotherapy
Authors: Pruett Megan , Williamson Lewis Rebecca , Klosky James L. , Effinger Karen E. , Meacham Lillian R. , Cherven Brooke 
Published: May 2023

AbstractThe extent to which heavy metal chemotherapy results in treatment‐related ovarian damage is controversial. Anti‐Mullerian hormone (AMH) levels measured more than 1 year after cancer therapy completion were abstracted from the medical records of 39 female survivors of childhood cancer aged 11 years and older, whose only gonadotoxic exposure was heavy metal chemotherapy. One‐fifth of survivors who received cisplatin had AMH levels indicative of diminished ovarian reserve at last measurement. There was an observed clustering of low AMH in patients diagnosed in the peripubertal age range (i.e., 10–12 years). These findings may support a small, but present, risk of gonadal damage after heavy metal chemotherapy.
Publication outlets for school psychology faculty: 2016–2020
Authors: Hulac David M. , Aspiranti Kathleen B. 
Published: May 2023

AbstractThis study investigated the peer‐reviewed journal publication outlets and impact of school psychology faculty research from the years 2016 through 2020. The National Association of School Psychologists website was used to identify 972 faculty from 195 doctoral and nondoctoral school psychology programs. Faculty publications were identified through a Google Scholar search and using published faculty curriculum vitaes. Journal h‐index impact factors and 2‐year citation rates were collected through SCImago. There were a total of 4354 articles published across 1125 journals during the 5‐year span. The journals Psychology in the Schools, Contemporary School Psychology, and School Psychology were where school psychology faculty published the most and accounted for 13% of the total publications. The average 2‐year citation rate for all journals was 2.83 and the average h‐index for all journals was 69.62. Discussion focuses on the historical and recent trend of school psychology faculty publications and the expanding range of nonschool psychology journals in which faculty publish.
The effects of x‐axis time compression on the visual analysis of single‐case data
Authors: Dart Evan H. , Radley Keith C. 
Published: May 2023

AbstractSingle‐case design is a research methodology that entails repeated measurement to assess the influence of an independent variable on a dependent variable over time. Data collected in this manner are regularly analyzed using visual analysis of data displayed in a linear graph. Although there is agreement regarding critical elements of visual analysis, research has highlighted poor reliability between raters. One potential contributor to this poor reliability are variations in visual presentation of the data during construction of the linear graph. The current study sought to determine the potential effect of one common variation, scaling of the x‐axis by intervention session or by calendar date. Results of the study indicated a significant effect of x‐axis scaling, with data presented by session, rather than by calendar day, judged as reflecting larger intervention effects, Z = 1981, p < .001. This effect was consistent across graphs displaying treatment effects of various magnitudes. Results of the study are discussed with the respect to the standardization of visual representation of single case data.
Tea green leafhopper‐induced synomone attracts the egg parasitoids, mymarids to suppress the leafhopper
Authors: Wang Mengxin , Han Shanjie , Wu Yiqi , Lin Jinli , Zhou Jiangxuan , Han Baoyu 
Published: May 2023

AbstractBackgroundThe tea green leafhopper, Empoasca flavescens is the most important pest of tea plants in China. Mymarid attractants based on herbivore‐induced plant volatiles (HIPVs) from leafhopper feeding and oviposition‐induced plant volatiles (OIPVs) were formulated and tested as a novel pest control agent against the leafhopper in tea plantations.ResultsResults showed that two mymarid species, Stethynium empoascae and Schizophragma parvula, had a reducing effect on leafhopper populations. The HIPVs and OIPVs were identified and bioassayed to screen the key synomones showing strong attraction to the mymarids. They were formulated into different blends, of which Field Attractant 1, comprising linalool, methyl salicylate, (E)‐2‐hexenal, perillen and α‐farnesene at ratio of 1:2:3:58:146 (20 mg/lure), showed the strongest attraction to the mymarids. In field trials with the attractant, the average parasitism rate (60.46 ± 23.71%) of tea leafhoppers by the two mymarids in the attractant‐baited area was significantly higher than that (42.85 ± 19.24%) in the CK area. Also, the average leafhopper density (46 ± 30 per 80 tea shoots) in the attractant‐baited area was significantly lower than that (110 ± 70 per 80 tea shoots) in the CK area.ConclusionThis study showed that a synthetic blend of key volatiles from HIPVs and OIPVs at an optimal ratio can be formulated into an attractant with the potential to attract and retain wild mymarid populations to suppress leafhopper populations in infested tea plantations, so as to reduce or avoid the spraying of insecticides. © 2023 Society of Chemical Industry.
Adaptive output feedback control of uncertain nonlinear systems with input saturation
Authors: Mi Yize , Yao Jianyong 
Published: May 2023

AbstractThis article concerns with the tracking control problem for a class of control‐affine nonlinear systems subject to input saturation, parametric uncertainties and unmodeled uncertainties. The proposed scheme consists of a nested‐saturation‐function‐based controller integrated with feedforward model compensation. A saturated linear extended state observer (SLESO) and parameter adaptation law are constructed to compensate for the unmodeled uncertainties and parametric uncertainties, respectively. By using these mechanisms, the steady‐state tracking performance can be guaranteed through uncertainty compensation. Additionally, the issue of conservativeness in the input saturation problem is effectively addressed through online‐updating the available unsaturated region, which improves transient performance. The proposed scheme results in asymptotic stability when unmodeled uncertainties are constants and ultimate boundedness when unmodeled uncertainties are time‐varying. Finally, simulation studies are presented to demonstrate the effectiveness of the proposed approach.
A Chip Off the Old Block: Do Reading‐Motivated Parents Raise Reading‐Motivated Children?
Authors: Cubillos Montserrat 
Published: May 2023

AbstractThe aim of this study was to investigate the relationship between parents' reading motivation and leisure reading frequency and their children's reading motivation. Secondary data analysis was used to examine a sample of almost 330,000 Chilean adolescents. The results of multilevel regression models revealed that parents' reading motivation and frequency were significantly and positively associated with adolescents' reading motivation, even after controlling for their classmates' and their own previous reading achievement. Furthermore, the negative and significant association found between students' reading motivation and their socioeconomic status was smaller in effect size than that of parents' reading motivation and frequency combined. The implications and limitations of these findings are also discussed.
Value as ethics: Climate change, crisis, and the struggle for the future
Authors: Field Sean 
Published: May 2023

AbstractDrawing on ethnographic research in Houston, Texas, I contribute novel ethnographic insights into how oil and gas experts understand notions of value. I show that prevailing notions of value are normatively defined in economic terms and closely tied to understandings of an American “way of life.” Questions of value, I suggest, reveal our idiosyncratic and shared ethical orientations toward what we think is important and the futures we are fighting to create. The climate crisis, as such, is not a crisis of emissions or hydrocarbons but a crisis of how value is assigned to worldly things. I conclude by arguing that until we address questions of value, we are unlikely to address the existential crisis of anthropogenic climate change.
Fractured Ownership and the Tragedy of the Anticommons in Hawai‘i
Authors: Khorasani Danae G. 
Published: May 2023

AbstractThe decline in the number of Native Hawaiian–ownedkuleanaproperties is partly the result of legal frameworks surrounding heirs' property adjudication, which does not easily allow families with multiple owners to collectivize their interests. As a result, families are made vulnerable to land dispossession by developers' use of quiet title and partition actions through the courts. Based on fieldwork that incorporates ethnography and archival research, I explore the disjunction of kin‐based patterns of inheritance within a culturally Western legal framework that values one owner, one property scenario. A novel analysis of heirs' property reveals the extent to which current legal doctrine is inherently unsuited to address both real and intangible inheritance patterns, thereby creating property and wealth destruction characteristic of a tragedy of the anticommons.
Complementary and integrative health therapies in whole person resilience research
Authors: Pitcher Mark H. , Edwards Emmeline , Langevin Helene M. , Rusch Heather L. , Shurtleff David 
Published: May 2023

AbstractComplementary and integrative health approaches can improve health and well‐being, as well as play an important role in disease prevention. The concept of whole person health builds on these concepts by empowering individuals, families, communities, and populations to improve their health in multiple interconnected domains: biological, behavioural, social, and environmental. Research on whole person health involves studies of interconnected biological systems and complex approaches to prevention and treatment. Some of these approaches may involve methods of diagnosis and therapy that differ from those used in conventional Western medicine. Of growing interest is how complementary, integrative, and whole person health approaches contribute to resilience. This brief commentary describes an integrated framework for mapping the connections between various complementary and integrative health therapeutic inputs onto aspects of resilience, including the ability to resist, recover (partially or fully), adapt, and/or grow in response to a following a stressor. The authors present selected examples of research studies supported by the National Institutes of Health that test whether complementary and integrative health approaches can promote some aspect of resilience. We conclude with a discussion of the challenges and opportunities in incorporating the study of resilience in complementary, integrative, and whole person health research.
All families of transposable elements were active in the recent wheat genome evolution and polyploidy had no impact on their activity
Authors: Papon Nathan , Lasserre‐Zuber Pauline , Rimbert Hélène , De Oliveira Romain , Paux Etienne , Choulet Frédéric 
Published: May 2023

AbstractBread wheat (Triticum aestivum L.) is a major crop and its genome is one of the largest ever assembled at reference‐quality level. It is 15 Gb, hexaploid, with 85% of transposable elements (TEs). Wheat genetic diversity was mainly focused on genes and little is known about the extent of genomic variability affecting TEs, transposition rate, and the impact of polyploidy. Multiple chromosome‐scale assemblies are now available for bread wheat and for its tetraploid and diploid wild relatives. In this study, we computed base pair‐resolved, gene‐anchored, whole genome alignments of A, B, and D lineages at different ploidy levels in order to estimate the variability that affects the TE space. We used assembled genomes of 13 T. aestivum cultivars (6x = AABBDD) and a single genome for Triticum durum (4x = AABB), Triticum dicoccoides (4x = AABB), Triticum urartu (2x = AA), and Aegilops tauschii (2x = DD). We show that 5%–34% of the TE fraction is variable, depending on the species divergence. Between 400 and 13,000 novel TE insertions per subgenome were detected. We found lineage‐specific insertions for nearly all TE families in di‐, tetra‐, and hexaploids. No burst of transposition was observed and polyploidization did not trigger any boost of transposition. This study challenges the prevailing idea of wheat TE dynamics and is more in agreement with an equilibrium model of evolution.
Assessment of tropical suburban surface soils contamination from Jengka, Malaysia
Authors: Sulaiman Fazrul Razman , Jusoh Mohammad Syahirul Aiman , Nasaruddin Amirul Amin , Sulaiman Noorzamzarina 
Published: May 2023

AbstractHeavy metals in suburban soils pose both indirect and direct health risks. This study assessed the concentrations of Cr, Zn, Pb, and Cd in Jengka (Malaysia) suburban soil and estimated the human health risk. Health risk assessment (HRA) was utilized to assess non‐cancer and cancer risks. The concentrations of heavy metals increased in the following order: Cd < Zn < Cr < Pb. The heavy metals were found to be divided into two components using principal component analysis (PCA), with PC1 comprising Pb and Cd and PC2 containing Zn and Cr. PC1 originates from anthropogenic sources, while PC2 is often from mixed anthropogenic and natural sources. Despite having the lowest mean concentration, Cd was enriched based on the geo‐accumulation index (Igeo) and enrichment factor (EF). Average hazard index values were below the acceptable threshold (HI < 1) for dermal and inhalation pathways suggesting a low non‐cancer risk. Jengka suburban soil had total lifetime cancer risk values slightly higher than the acceptable threshold (1 × 10−5). Skin contact was the most prominent contributing exposure pathway for both non‐carcinogenic and carcinogenic risks. This study suggests that heavy metal bioactivity levels be used to make a plausible HRA of heavy metal pollution in suburban soils.
The Poisson-Nernst-Planck (PNP) Model
Authors: Horgmo Jæger Karoline , Tveito Aslak 
Published: May 2023

AbstractIn these notes, we have considered models of electrophysiology across several scales. The first was the membrane model. It assumes that the action potential is similar across the whole cell membrane, and the model represents the action potential as a function of time alone. No spatial variable is involved in the pure membrane models, so a length scale of these models does not make sense.
Ausgangslage: Energie- und Rohstoffwirtschaft im Spannungsfeld von gesellschaftlicher Notwendigkeit und bürgerschaftlichem Protest
Authors: Walter Stefanie 
Published: May 2023

Zusammenfassung„KIES IST MIES“ (NEIN zum Sand- und Kiesabbau in Königshain, Claußnitz & Altmittweida, 2020b), „REST IN KIES“ (ebd.) und „Bei uns ist KEIN KIES zu holen!“ (NEIN zum Sand- und Kiesabbau in Königshain, Claußnitz & Altmittweida, 2020a) – diese Slogans sind auf Plakaten und Schildern in und um Altmittweida zu lesen: Bürger:innen engagieren sich gegen den seit 20 Jahren in Planung befindlichen Sand- und Kiesabbau vor Ort. Teile der mittelsächsischen Bevölkerung positionieren sich gegen den Rohstoffabbau, gegen fossile Energieumwandlung oder den Bau erneuerbarer Energieumwandlungsanlagen in ihrem Umfeld. Auf regionaler Ebene ist bürgerschaftlicher Widerstand eher Normalfall denn Ausnahme (Rugenstein, 2017).
Ergebnisse: Analyse der (In-)Akzeptanz und Ableitungen zur kommunikativen Steigerung
Authors: Walter Stefanie 
Published: May 2023

ZusammenfassungIn diesem Kapitel werden die Ergebnisse der Analysen analog der Reihenfolge der FK vorgestellt. Zuerst wird die (In-)Akzeptanz der Bevölkerung sowie die Befunde zu den Akzeptanzfaktoren dargelegt. Daran schließen sich die Ergebnisse zur sächsischen Energie- und Rohstoffbranche an. Es folgen Ausführungen zum Nutzen und den Möglichkeiten der Akzeptanzsteigerung mittels Kommunikation. Die Erkenntnisse führen zur Vorstellung der auf dieser Grundlage entwickelten Webapplikation sowie deren Evaluierung. Beendet werden die Ausführungen mit Ableitungen zur Steigerung der soziopolitischen Akzeptanz.
Soziologische Theorie und Recht
Authors: Bora Alfons 
Published: May 2023

ZusammenfassungTheorien des Rechts haben die Soziologie seit ihren Anfängen wesentlich mit geprägt. Soziologische Klassiker wie Emile Durkheim, Ferdinand Tönnies oder Max Weber haben dem Recht nicht zufällig erhöhte Aufmerksamkeit gewidmet. Sie griffen entweder auf juristische Examina wie Weber, einen philosophischen Werdegang wie Tönnies oder auf Begegnungen mit den Staatswissenschaften wie der junge Durkheim während seines Studienaufenthaltes in Deutschland zurück und waren deshalb mit den großen rechtstheoretischen Debatten ihrer Zeit vertraut.
Institution und Reflexion – Die Schwäche der Rechtssoziologie und die Semantik der Interdisziplinarität
Authors: Bora Alfons 
Published: May 2023

ZusammenfassungUnseren Überlegungen liegt die Vermutung zugrunde, dass die Rechtssoziologie ein Muster der Selbstbeschreibung in Form einer asymmetrischen Beziehung zwischen Recht und Soziologie entwickelt hat, in welcher die Frage nach der Rezeption soziologischen Wissens in Rechtspraxis und Jurisprudenz im Vordergrund steht. Die vielfältigen Auseinandersetzungen zwischen Erfahrungs- und Normwissenschaften nahmen, wie im Folgenden zu zeigen sein wird, fast durchweg diese Gestalt an. Bis heute, über ein Jahrhundert nach der Entstehung der Rechtssoziologie im deutschsprachigen Wissenschaftsraum, ist die Identität der Rechtssoziologie in dem im ersten Kapitel dargelegten Sinne unklar geblieben, nicht zuletzt als Folge dieser in historischen Zeiträumen gewachsenen Selbstbeschreibung.