bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid Alert System for Food and Feed reports as a source of information on food hazards
Authors: Mikulec Anna , Zborowski Marek , Kowalski Stanisław 
Published: February 2023

Introduction
Food safety is a major challenge worldwide and an important factor frequently taken into account by consumers when making food choices. Over the years, a number of unfavorable phenomena related to food adulteration and an increase in its contamination have been observed, which in turn translates into a lower level of food quality and safety and a decrease in consumer confidence.
Aim
The aim of this study was to analyze the Rapid Alert System for Food and Feed (RASFF) reports from 2019-2021 in terms of types of hazards in food.
Materials and methods
The research material consisted of the annual reports of the RASFF for the years 2019-2021.
Results
The submissions to the RASFF per product type system were dominated by those related to food. In 2020 and 2021, the most notifications concerned fruits and vegetables, dietetic food, food supplements, and fortified foods. In the group of 10 products causing the most frequent notifications, there are products of animal origin: meat and meat products (other than poultry), fish and fish products, milk and milk products, poultry meat and poultry meat products. The main threats associated with food in the last three years were contamination with Salmonella in poultry meat and poultry meat products, herbs and spices, and nuts, nut products and seeds; aflatoxins, especially in nuts, nut products and seeds; and pesticide residues in fruit and vegetables.
Conclusion
The observed increase in the number of notifications in the RASFF reports in 2019-2021 shows that all EU Member States are involved in monitoring food safety risks. The functioning of the RASFF system enables immediate action to be taken in the EU countries in relation to the risk, and allows for quick information transfer and elimination of products that are hazardous to the health of the consumer.
An Inferential Aptness of a Weibull Generated Distribution and Application
Authors: Singh Brijesh P. , Das Utpal Dhar 
Published: February 2023

In this article an attempt has been made to develop a flexible single parameter continuous distribution using Weibull distribution. The Weibull distribution is most widely used lifetime distributions in both medical and engineering sectors. The exponential and Rayleigh distribution is particular case of Weibull distribution. Here in this study we use these two distributions for developing a new distribution. Important statistical properties of the proposed distribution is discussed such as moments, moment generating and characteristic function. Various entropy measures like Rényi, Shannon and cumulative entropy are also derived. The kth order statistics of pdf and cdf also obtained. The properties of hazard function and their limiting behavior is discussed. The maximum likelihood estimate of the parameter is obtained that is not in closed form, thus iteration procedure is used to obtain the estimate. Simulation study has been done for different sample size and MLE, MSE, Bias for the parameter λ has been observed. Some real data sets are used to check the suitability of model over some other competent distributions for some data sets from medical and engineering science. In the tail area, the proposed model works better. Various model selection criterion such as -2LL, AIC, AICc, BIC, K-S and A-D test suggests that the proposed distribution perform better than other competent distributions and thus considered this as an alternative distribution. The proposed single parameter distribution is found more flexible as compare to some other two parameter complicated distributions for the data sets considered in the present study.
Epithelial-mesenchymal transition as a potential route for DAPT resistance in breast cancer cells
Authors: Telli Kubra , Yalcin-Ozuysal Ozden 
Published: February 2023

Abstract

Objectives
Notch is a conserved pathway involved in cell-fate determination and homeostasis. Its dysregulation plays a role in poor prognosis and drug resistance in breast cancer. Targeting Notch signaling via inhibition of the gamma-secretase complex is in the spotlight of modern cancer treatments. Gamma-secretase inhibitors (GSI) have shown successful clinical activity in treating cancers, yet the possible resistance mechanism remains unstudied. Modeling the resistance and understanding culprit molecular mechanisms can improve GSI therapies. Accordingly, the aim of this study is to generate and analyze GSI-resistant breast cancer cells.

Methods
Gradually increasing doses of DAPT, a well-known GSI, were applied to MCF-7 breast cancer cell lines to generate resistance. Cell viability, migration and gene expressions were assessed by MTT, wound healing and qRT-PCR analyses.

Results
DAPT-resistant MCF-7 cells exhibited abnormal expression of Notch receptors, Notch targets (HES1, HES5, HEY1), and epithelial-mesenchymal transition (EMT) markers (E-cadherin, ZO-1, SNAIL2, N-cadherin) to overcome the continuous increase in DAPT toxicity by increased migration through mesenchymal transition.

Conclusions
This study prospects into the role of EMT in the potential resistance mechanism against DAPT treatment for breast cancer cells. Complementary targeting of EMT should be investigated further for a possible effect to potentiate DAPT’s anti-cancer effects.
Microstructure, Mechanical Properties, and Fatigue Resistance of High-Carbon Steel for Tensile Wires Used in Flexible Pipes for Offshore Oil and Gas Transportation
Authors: dos Santos T. M. , dos Santos Fernanda C. S. C. , Tavares S. S. M. , Landim R. V. , Velasco J. A. C. 
Published: February 2023

Abstract
Tensile armor carbon steel wires are structural elements assembled in the complex construction of flexible pipes used in the oil and gas industry. Recently, failures of flexible pipes were associated with tensile armor fractures. Despite the relevant key of these elements in the structure of flexible pipes, manufacturers and steelmakers do not provide sufficient information about the materials and their production flow. The objective of the present study was to characterize a tensile wire made of cold worked high carbon steel regarding the microstructure and mechanical properties. The microstructure was investigated by high resolution scanning electron microscopy. The steel has nearly eutectoid chemical composition (0.69 % carbon) and presents a microstructure of very fine and deformed pearlite. Some cementite carbides appeared fragmented and spheroidized in the ferrite matrix. These microstructural features are typical of patented steel, which was subsequently cold deformed by rolling and drawing. The tensile curve of the material was obtained and modeled by Hollomon’s, Voce’s and Ludwik’s constitutive equations. The S– N fatigue curve of the wire was constructed with four-point bending tests with ratio R = 0.1. The endurance limit for R = 0.1 was estimated, and the correspondent value for R = −1 was calculated based on Goodman’s relation.
On the optimal level of theatre subsidies
Authors: Suominen Seppo 
Published: February 2023

This article examines public subsidies and ticket pricing in Finnish theatre institutions by using the principal-agent model. The model follows the ideas presented by Prieto-Rodríguez and Fernández-Blanko (2006) in their article on the British museum sector. The idea of this article is to test how well their theoretical model is in line with the data on Finnish theatres. The aim of this paper to justify the high share of public subsidies to theatre sector and to show that ticket pricing should be in the inelastic segment on the demand schedule. The data on Finnish theatres covers years 2007 – 2011 with 58 theatres subsidised by the law, including the Finnish National Opera. The results of the empirical examination show that the demand of theatre services is price inelastic. According to the results, an increase in the number of visitors increases also optimal subsidies but less than proportionally indicating that the share of public subsidies should be lower in larger towns where the potential for theatre visits is higher due to a larger population. The article argues that even though using economic approaches in examining arts and culture is not unproblematic, they should be used and further developed.
Robson’s ten group classification: a tool for predicting cesarean section rates
Authors: Tiwari Meghna , Singh Sanghmitra , Kushwah Beenu Singh 
Published: February 2023

Background: Increasing cesarean section delivery rates in India and world is a serious maternal health concern. It is important to understand the trends, reasons behind this change and to find ways to achieve optimum cesaerean section (CS) rates. As per the latest data national family health survey 2019-21 (NFHS 5), CS rates at population level in India seems to be 22% while WHO recommends 10-15% threshold. So, we aim to analyze trend of CS and evaluate it according to Robson’s 10 group classification at tertiary care hospital in Rewa, Madhya Pradesh, India.
Methods: A cross sectional study was conducted at department of obstetrics and gynecology, Shyam Shah medical college Rewa for 3 years from May 2019 to April 2022 on all deliveries occurring on or after 28 weeks of gestation by cesarean section.
Results: Total of 26552 deliveries over 3 years period were analyzed, of these 7484 were CSs (28.18%). Overall C section rate increased from 18.97% in 2019 to 39.95% in 2022. Major contributors to this increase were Robson’s group 5-32.58%, Robson’s group 1-29.45% and Robson’s group 2-12.22%.
Conclusions: Robson’s group 1, 2 and 5 were major contributors to overall increased cesarean section rates. Fetal compromise, meconium aspiration risk, obstructed labor and cesarean scar tenderness were underlying indications for most of the cesarean sections done. Efforts should be made to implement standard protocol to reduce primary cesarean section rates.
Urothelial carcinoma of urinary bladder with histologic grading: a study in a tertiary care hospital, Bangladesh
Authors: Islam M. Ariful , Mir Ratim , Jinnah Mohammed S. Ali , Sweety Rumana A. , M. M. Rahman  
Published: February 2023

Background: Urinary bladder cancer is one of the most common forms of all cancers in the world. It is the ninth leading cause of death from cancer among men. The incidence of urinary bladder cancer in Bangladesh is increasing day by day. The aim of the study was to evaluate different clinic-pathological parameters of urothelial carcinoma of urinary bladder with the grade of the tumor.
Methods: This study was a cross sectional study done over a period of two years, from March 2018 to February 2020 at the department of pathology, Dhaka medical college, Dhaka. Total 73 samples were collected, fixed overnight in 10% buffered formalin and stained with hematoxylin and eosin staining. Pathological grading was confirmed and different clinic-pathological parameters were evaluated.
Results: Most of the cases (22 cases, 30.1%) were found in the fifth decade (51-60). Mean age of the patients was found to be 60.85 (±12.72) years, 58 (79.5%) cases were male and 15 (20.5%) cases were female with male to female ratio of 3.9:1. Most of the cases (49 cases, 67.1%) were smokers. Most common clinical presentation was hematuria (91.8% cases), most frequent tumor location was the lateral wall of the urinary bladder and 75.3% cases were reported as high-grade urothelial carcinoma.
Conclusions: Different clinic-pathological parameters with histologic grading were evaluated in this study which may have a significant impact in epidemiology, diagnosis and assessment of biological behavior of urothelial carcinoma.
A prospective study of the functional outcome of 3 stitch technique in a compound humerus shaft fracture
Authors: Sachin Kale  , Raju Patil  , Suraj S. Doshi  , Dey Joydeep Kumar , Shashwat Anand  , Ravi Rajan Modi  , Sonali Das  
Published: February 2023

Background: Intramedullary nailing of compound shaft humerus fractures has been an innovative and surgically friendly technique to deal with extensive soft tissue injury that impedes open reduction and internal fixation. The purpose of this article is to highlight the minimally invasive technique of intramedullary humerus nailing to prevent the perioperative and postoperative complications encountered. A 1 year follow up of all the patients have shown functionally excellent results and good surgical outcome.
Methods: We have conducted this prospective study from Jan 2020 to Jan 2022 at DR. D.Y. Patil medical college and hospital. Informed consent from each patient was taken explaining the methods of study and probable complications. By this 3-stitch technique we have treated 25 adult patients sustaining post traumatic compound humerus shaft fractures by Antegrade humerus nailing. We have included compound injury upto type 3A (Gustilo-Anderson classification).
Results: Out of the 25 patients, 23 patients showed functionally excellent outcomes with good compliance to rehabilitation protocol but 2 patients had delayed wound healing of which 1 patient had undergone VAC therapy, which later healed well after a period of 2-3 weeks with sequential dry dressings. None have gone into nonunion.
Conclusions: Our study suggests that the 3-stitch technique is a good alternative method compared to external fixators and other various surgical techniques and yields good results with lesser complications and better cosmetic outcomes in compound injuries.
Implementation of Character Education in Elementary School Using The QR Code During The Covid-19 Pandemic
Authors: Diharja Umar , Yanti Dwi , Sasongko Rambat Nur , Kristiawan Muhammad 
Published: February 2023

The application of character education during the Covid-19 pandemic underwent changes that needed to be adapted to conditions, one of which was character education in elementary schools. This study aimed to know the implementation of character education using the QR Code at SDIT Mutiara Cendekia Lubuklinggau. This study was conducted by implementing qualitative method. The data were collected through documentation and interviews with two teachers and the principal of the school while the data analysis was conducted through inductive techniques, through steps of data reduction, data display and drawing conclusion. The research findings showed the following results: 1) character education was still carried out despite the Covid-19 pandemic; 2) the use of QR code technology in the form of photos or videos made them attractive for the students Thus, the character education by using QR codes for character education at SDIT Mutiara Cendekia Lubuklinggau could run well regardless of the Covid-19 pandemic.
BOTELLA TEJERA, Carla; AGULLÓ GARCÍA, Belén (eds.). Mujeres en la traducción audiovisual. Perspectivas desde el mundo académico y el profesional. Madrid: Sindéresis, 2021. ISBN: 978-84-18206-80-1. 276 pp.
Authors: Ogea Pozo Maria del Mar 
Published: February 2023

Reseña de BOTELLA TEJERA, Carla; AGULLÓ GARCÍA, Belén (eds.). Mujeres en la traducción audiovisual. Perspectivas desde el mundo académico y el profesional. Madrid: Sindéresis, 2021. ISBN: 978-84-18206-80-1. 276 pp.
A clinical study on the combined effectiveness of Pathyadi Churna and Kshara Basti in Amavata (Rheumatoid Arthritis)
Authors: Nehaa Srinivasan  , Girish KJ  , Sunil Sabasannavar Jinnappa  , Vibhu Sudhakar Powar  
Published: February 2023

Background & Objectives: Amavata (Rheumatoid Arthritis-RA) is a disease caused due to deranged Agni leading to Ama formation. The Lakshanas are very similar to Rheumatoid Arthritis (RA), an autoimmune disorder which causes chronic inflammation and symmetric, peripheral polyarthritis. Pathyadi Churna and Kshara Basti are mentioned in the classics for the treatment of Amavata. Methods: Among 33 registered patients, 30 of them completed the course of treatment. They were administered with Pathyadi Churna 1 Karsha (12g) thrice daily before food with Ushnodaka as Anupana (adjuvant) for a period of 15 days along with Kshara Basti in a modified Yoga Basti format for the first 5 days. Friedman's test with Wilcoxon sign rank test as post hoc was used to analyze the significance of change in Ordinal data and Repeated measure ANOVA after applying Bonferroni correction and Paired t test as post hoc was used to analyze the significance of change in Scale data. Results: There was statistically significant improvement in the primary and secondary outcome measures of Amavata. Interpretation and Conclusion: Pathyadi Churna and Kshara Basti are effective in the management of Amavata.
A clinical study in the management of Garbhini Mutrakricchra with Shatavari Ksheerapaka w.s.r. to UTI in Pregnancy
Authors: Deepshikha Sharma  , Savita S. Patil  
Published: February 2023

Background: Pregnancy is the state of carrying a developing embryo or fetus within the female body. Profound biochemical, anatomical and physiological changes occur during the course of pregnancy. Urinary tract infections are the second most common infections worldwide. Pregnant women have 4 times higher rate of developing UTI as compared to non-pregnant women. Pregnant women develop ureteral dilation resulting in increased urinary stasis and ureterovesical reflux due to increased progesterone level and the pressure of gravid uterus on the bladder. The classical Lakshanas of Mutrakricchra like frequent micturition, difficulty during micturition, burning sensation during micturition are similar to the signs and symptoms of Urinary tract infection. Shatavari Ksheerapaka has been mentioned in Sahasrayogam for the management of Mutrakricchra. Shatavari is Sheeta in Virya, acts as a diuretic and helps in the reduction of Mutrakricchra symptoms. According to Bhavprakash Nighantu, Sita is Ruchikara and Ksheera is Rasayana. Aim: To evaluate the efficacy of Shatavari Ksheerapaka in Garbhini Mutrakricchra w.s.r UTI in Pregnancy. Method: It is a controlled clinical study of two groups consisting 15 patient each in control and trial group. Conclusion: Shatavari Ksheerapaka and Trinapanchmoola Ksheerapaka both are equally effective in treating the Garbhini Mutrakricchra w.s.r. UTI in Pregnancy.
Relation of Prakriti and Skin Color - An Observational Study
Authors: Rajeshwari Vantagodi  
Published: February 2023

Prakriti is one of the most important concepts in Ayurveda which is of 7 types i.e., Vataja, Pittaja, Kaphaja, three Dwandaja and one Sannipataja. Prakriti is first Pariksha mentioned in Charaka Samhita among Dashavidhapariksha. Assessment of Prakriti is done based on Anatomical, Physiological, Psychological, and Behavioural factors. Twak Shareera is one of the important anatomical features used in the assessment of Prakriti. In this article, an attempt is made to understand the color of Twak and its relationship with Prakriti. An observational study of 150 healthy subjects was conducted to assess the Prakriti of individual and its relationship with Twak Shareera. We used Von Luschan's chromatic scale (VLS) and The Fitzpatrick scale for classifying skin color. The more the VLS Score, the darker the skin color is. The present study showed that VLS Score increases wherever there is involvement of Vata and Fitzpatrick scale showed that Vataja Prakriti are more of Dark brown in color compared to Pitta. Thus, it can be said that skin color is Genetic in nature and correlated with our theory of Prakriti.
A randomised controlled clinical study to evaluate the role of Nirvapana Upakrama with Durva ointment in the management of Pittaja Dushta Vrana with special reference to fissure-in-ano
Authors: Parvathy Gopan  , Padma  , KM Sweta  , Dhyan Surendranath  
Published: February 2023

Introduction: Fissure-in-ano is an ulcer in the longitudinal axis of lower anal canal. It is having prevalence of about 17.91%. By seeing the signs and symptoms we can consider it as one among the six varieties of Dushta Vrana i.e., Pittaja Dustavrana. Due to busy life schedules people don’t prefer hospitalization and other operative procedures. So, there is a need to find out a new and simpler medicament which enables easy and better storage, preservation and mode of application. Here an attempt was made to study the effect of Nirvapana Upakrama in the management of fissure in ano is taken. This Upakrama is used for the treatment of Vrana accompanied with Daha, Paka, Jwara and having Pitta Kopa and Raktena Abhibhuta. Since fissure is having the similar symptoms this treatment can be adopted for the management of the same. Methodology: A randomized controlled clinical study was conducted over 30 subjects in two groups. Fifteen subjects were advised to apply Diltiazem gel and 15 subjects were advised to apply Durva ointment twice daily for a period of 14 days. Results: Rapid reduction in pain, burning sensation and length of ulcer was observed in the subjects who were given Durva ointment. Discussion: Durva ointment having Madura Rasa, Snigdha Guna and Sheeta Virya does Vatapitta Shamana and pacifies vitiated Rakta. Kashaya rasa of Durva does Vrana Ropana and Rakta Sthambana which amplifies in ulcer healing and relaxation of the sphincter.
A randomized comparative clinical study to evaluate the effect of Ghanavyoshadi Khanda over Vidarikandadi Khanda in Karshya w.s.r. to Underweight Children
Authors: Aparna KP  , Prathviraj Puranik  , Nagaratna SJ  , Sandesh Shetty  
Published: February 2023

Background: Undernutrition is one of the major causes of increased morbidity & mortality among children. One of the most emerging issues in the present scenario is having long-term effects on physical & cognitive development. Underweight is one of the cardinal determinants of under nutrition. According to a 2019 report, India is ranked 102 out of 119 countries. As per NFHS 4 in India shows 35.7% under 5 children were underweight, 38.4% were stunted & 21% were wasted. Karshya is an Apatarpana Janya Vyadhi. The trial was proposed to study the comparative effect of Ghanavyoshadi Khanda & Vidaryadi Khanda by using specific parameters for Karshya w.s.r. to underweight. Objective: To evaluate the comparative effect of Ghanavyoshadi Khanda over Vidarikandadi Khanda in the management of Karshya. Materials & Methods: Children of age group 2-5 years were selected from Kaumarabhritya OPD of SDM College of Ayurveda & Hospital, Udupi, also from nearby Anganwadi’s & preschool of Udupi. Selected subjects were randomly allocated into 2 groups of 15 patients each. Group A will be administered with Ghanavyoshadi Khanda along with Sukoshna Ksheera as Anupana twice daily before food and group B with Vidarikandadi Khanda along with Sukoshna Ksheera as Anupana twice daily after food for 1 month. Results: Children showed improvements in all aspects of Karshya w.s.r. to underweight like weight, height, MUAC, & BMI. Both the groups showed highly significant improvement in Kshut, Abyavarana Sakti & significant changes in Badhavitt. Insignificant changes in Alpapranaschakriya, Pipasa & Nidra. Conclusion: It was concluded clinically the consumption of Ghanavyoshadi Khanda & Vidaryadi Khanda along with Sukoshna Ksheera are equally effective in the management of Karshya w.s.r. to underweight in children.