bluuebunny/crossref_metadata_2025_split huggingface dataset:
An in silico investigation and introduction of some secondary metabolites of medicinal plants with antiviral activity and effective vitamins for the treatment of MPox
Authors: Poy Donya , Tohidfar Masoud 
Published: January 2023

Abstract
Unfortunately, the world today is facing the dangers of bioterrorism. Bioterrorism has a long history, and contaminated and infectious materials, corpses, and animal carcasses have been used since ancient times. Therefore, we must be prepared to deal with them. After the eradication of smallpox through vaccination, vaccination was stopped worldwide, and this caused the next and enlarged generation of orthopoxviruses, including Mpox, to be of great concern. Again today, while we have very preliminary research, we are faced with a widespread outbreak of the MPox virus around the world. One of the important and available medicinal resources for the public in all countries is the native medicinal plants of each country. In addition to the independent use of medicinal plants, they can be good medicinal supplements along with the use of approved drugs. In many studies, functional compounds derived from medicinal plants called secondary metabolites have been proven to treat various chronic diseases with anti-cancer, antibacterial, antifungal, antiviral, anti-inflammatory, and allergy activities. Because smallpox and MPox have genetically similar conserved regions, this study was planned with the approach of investigating the inhibitory mechanism of drugs that are used to treat smallpox and is approved by the FDA (Tecovirimat, Brincidofovir, and Cidofovir). Additionally, to investigate the effect of plant metabolites and vitamins on the MPox virus' cell surface protein on preventing virus entry into the cell and causing infection. So far, no studies have been reported on vitamins and plant metabolites in the inhibition of the MPox virus. Some of the valuable candidate plant metabolites in this study such as gingerol in Ginger (Zingiber officinale Roscoe), Rosmarinic acid in Selfheal (Prunella vulgaris L.), Rosemary (Salvia rosmarinus), and Oregano (Origanum vulgare), Gallotannin in Aleppo oak (Quercus infectoria) and in Chinese nutgall (Rhus chinensis) can be potential inhibitors to inhibit MPox virus.
Giant energy storage ultrafast microsupercapacitors via negative capacitance superlattices
Authors: Cheema Suraj , Shanker Nirmaan , Hsu Shang-Lin , Schaadt Joseph , Ellis Nathan , Cook Matthew , Rastogi Ravi , Pilawa-Podgurski Robert , Ciston Jim , Mohamed Mohamed , Salahuddin Sayeef 
Published: January 2023

Abstract
Dielectric electrostatic capacitors, due to their ultrafast charge-discharge capability, are attractive for high power energy storage applications. Along with ultrafast operation, on-chip integration can enable miniaturized energy storage devices for emerging autonomous microelectronics and microsystems. Additionally, state-of-the-art electrochemical miniaturized energy storage systems – microsupercapacitors and microbatteries – currently face safety, packaging, materials, and microfabrication challenges preventing on-chip technological readiness, leaving an opportunity for electrostatic microcapacitors. Here we report record-high energy storage density (ESD) and power density (PD) across all electrostatic systems in HfO2-ZrO2 (HZO)-based thin film microcapacitors integrated directly on silicon, through a three-pronged approach. First, to increase intrinsic energy storage, atomic-layer-deposited antiferroelectric HZO films are engineered near a field-driven ferroelectric phase transition to exhibit amplified charge storage via the negative capacitance (NC) effect, which enhances volumetric-ESD beyond the best-known back-end-of-the-line (BEOL) compatible dielectrics (115 J-cm−3). Second, to increase overall stored energy, superlattice engineering of amorphous-templated HZO-Al2O3 heterostructures scales-up the high-storage antiferroelectric-NC behavior to the 100 nm regime, which overcomes the conventional thickness limitations of HZO-based (anti)ferroelectricity (10-nm regime). Third, to increase storage-per-footprint, the superlattices are conformally integrated into three-dimensional (3D) capacitors, which boosts areal-ESD (areal-PD) 9-times (170-times) the best known 3D electrostatic capacitors: 80 mJ-cm−2 (300 kW-cm−2). This simultaneous demonstration of ultrahigh ESD and PD overcomes the traditional capacity-speed trade-off across the electrostatic-electrochemical energy storage hierarchy. Furthermore, integration of ultrahigh-density and ultrafast charging thin films within a BEOL-compatible process enables monolithic integration of on-chip microsupercapacitors, which opens the door for substantial energy storage and power delivery for electronic microsystems.
Intraoral Myeloid Sarcoma as an Early Manifestation of Acute Myeloid Leukemia: Case Report and Literature Review
Authors: Grossi Letícia Dantas , França Rosimeire Plimolan , Rubira Cassia Maria Fischer , Santos Paulo Sergio Da Silva 
Published: January 2023

Abstract
Introduction: When acute myeloid leukemia first manifests, during treatment, or after relapsing, immature myeloid cells make up the extramedullary tumor known as oral myeloid sarcoma (AML). This article's goals are to evaluate instances that have been reported in the literature and to present the clinical characteristics of oral myeloid sarcoma.
Case presentation: This case involves a 45-year-old male patient who reported considerable pain and spontaneous bleeding in the vestibular gingiva on the left side, next to the upper premolars. The clinical findings of AML included petechiae in the area of the patient's lower limbs due to thrombocytopenia, which was confirmed in the CBC, in addition to the patient's presenting symptoms of fever, weakness, bodily aches, and diarrhea. A week before to his hospital admission, he started experiencing these symptoms. The initial lab findings showed that there were 231,410 total leukocytes/mm3, 27,000 platelets/mm3, 3.39 million mm/mm3 of red blood cells, and 222,154 circulating blasts, or 96% of total leukocytes. Myelography performed shortly after admission to the hospital showed the presence of cancerous cells, and immunohistochemistry confirmed the diagnosis of AML. Even though PAX-5, CD20, TDT, and CD3 were all negative, myeloperoxidase was positive.
Conclusion: We draw the conclusion that oral myeloid sarcoma is uncommon and that it is challenging for both doctors and dentists to diagnose and treat.
Developing of case-importing teaching module-integrated 2D pathology and 3D radiology to improve learning effect in undergraduates of stomatology
Authors: Zhang Baoping , Zhang Zhidong , Guo Dingcheng , Yan Yimin , Wang Di , Lu Lizhi , Yu Xin , Su Songhua , Zhang Kailiang , Zhang Jie , Liu Bin 
Published: January 2023

Abstract

Purpose The teaching concept of integrated curriculum is an important means of medical education improvement, which can arouse students' enthusiasm for learning, enhance the learning effect of basic and clinical subjects, and help students to establish interdisciplinary connection. This study aimed to combine stomatologic pathology-radiology courses with instructional media and to propose a new morphological integrated teaching mode for undergraduate stomatology education. Methods In total 84 undergraduates were divided into four teaching groups: traditional (Group T), KoPa WiFi EDU system (Group K), KoPa WiFi EDU-CBCT (Group K-C), and CBCT-KoPa WiFi EDU (Group C-K). Participants received a 2-hour lecture on periapical cysts and sat a theoretical test. Corresponding groups underwent a 4-hour experimental pathology and radiology course on periapical cysts using different teaching methods. Participants repeated the theoretical test with an experimental test. Teaching effects were assessed based on objective and subjective experimental test scores and difference in theoretical test scores. Results The results indicated no significant difference in the first theoretical outcomes among four groups (P > 0.05). The second theoretical scores, objective and subjective experimental scores of integrated teaching mode with KoPa WiFi EDU system and CBCT which scored 89.29 ± 4.55, 81.00 ± 8.15, 61.57 ± 5.52 (Group K-C) and scored 87.52 ± 3.44, 80.00 ± 9.22, 58.00 ± 4.44 (Group C-K) exhibited superior teaching effects comparing to traditional teaching mode (scored 72.57 ± 3.84, 69.38 ± 4.91, 48.67 ± 5.54) and 2D teaching mode with KoPa WiFi EDU system (scored 80.43 ± 3.41, 73.00 ± 8.01, 55.67 ± 5.66) (P < 0.05). In the integrated teaching mode, subjective scores were higher in Group K-C (pathology followed by radiology) than in Group C-K (radiology followed by pathology) (P < 0.05). Long-term teaching effect of integrated mode was better than traditional mode (P < 0.05). Conclusion The K-C group combined with 2D pathology and 3D radiology in the morphology-based integrated teaching mode was the most superior one for undergraduates’ learning effects.
Forecasting Deaths and Dalys Caused by Air Pollution for Saarc Countries Using Time Series and Neural Network Models
Authors: Amer Amna , Mushtaq Nadia 
Published: January 2023

Abstract
The polluted air factor is strong with the passage of time and its impact can easily be assessed by observing the related data. This research is designed to understand to what extent air pollution will contribute to deaths and DALYs in SARRC countries. Death and DALYs rates in SARRC countries due to air pollution are positively perceived. This study used time series and machine learning methods for forecasting deaths and DALYs caused by air pollution using machine learning techniques such as ARIMA, Exponential Smoothing, and Neural Network. Overall analysis shows that Ambient Particulate Matter Pollution (Ambient PM Pollution) and Ambient Ozone Pollution have an upward and Household Air Pollution (HAP) has a downward trend. The upward trend is an alarming factor for all the stakeholders. On the other, the downward trend means it is losing its intensity due to better behavior of people.
The effects of the Alexander Technique on Chronic Non-specific Neck Pain: A Systematic Review and Meta-analysis
Authors: Qin Di , Qin Ya xuan , Xue Lian , Wang Yu di , Peng Yong 
Published: January 2023

Abstract
Objective
To evaluate the clinical efficacy of the Alexander Technique courses compared to the conventional therapy in patients with chronic Non-specific neck pain.
Methods
According to PICO (participant, intervention, comparison, outcome) elements, the effects of Alexander Technique on chronic Non-specific neck pain were evaluated in this paper. PubMed, Web of Science, EBSCO, EMBESE, and Cochrane Library et al English databases were searched with a search time frame from databases build to December 31, 2021. Weighted mean differences (WMD), Standardized mean difference (SMD) and 95% confidence intervals (CIs) were calculated. We used a random-effects model to minimize the heterogeneity, and I2 test was used to assess heterogeneity.
Results
Three studies were included according to the predetermined eligibility criteria. Compared with the conventional therapy group, the merge of included studies showed that the Alexander Technique could significantly improve the pain for chronic neck pain patients, and the treatment effects can be maintained for 3–6 months with a very low heterogeneity (six-month follow-up pain outcome: SMD: -0.20, 95%CI: -0.38–0.01, P = 0.035, I2 = 15.7%; three-month follow-up pain outcome: -0.33, 95%CI: -0.53-0.13, P = 0.001, I2 = 0%). In addition, compared with the conventional therapy group, the Alexander Technique would not significantly increase adverse events (AE: RR = 1.690, 95% CI: 0.67–4.27, P = 0.267, I2 = 44.3%).
Conclusion
Although the number of studies and personnel involved was limited, the meta-analysis preliminarily indicated that the Alexander Technique courses is effective for chronic Non-specific neck pain, which is related to the follow-up time of the post-intervention. However, it’s necessary to interpret and apply the outcome of this research cautiously and the specific efficacy and mechanisms of Alexander Technique therapy are needed to be investigated to demonstrate further.
Systematic Review Registration:
PROSPERO, CRD420222361001.
Nano Silver Remineralization and Aesthetic Effect on Artificial White Spot Lesions: an in vitro study
Authors: Wael Hadeer , hegazy salwa , Ibrahim Rasha 
Published: January 2023

Abstract
Background : Evaluating the remineralization potential on artificial enamel caries of three different dentifrices containing , Casein Phospho peptide- Amorphous Calcium Phosphate (CPP-ACP) , Nano Silver Fluoride (NSF), and Sodium Fluoride (NaF), in comparison to Artificial Saliva ( ASS).
Methods : A standrardized demineralization protocol was used on sound extracted human premolars ( n=80) in order to create artificial carious – like lesions. Premolars were sectioned longitudinally . According to the type of treatment group , the teeth were randomly allocated into four equally sized groups (n=20) . Group A , was treated with Casein Phospho Peptide- Amorphous Calcium Phosphate (CPP-ACP) ; Group B , was treated with Nano Silver Fluoride (NSF) ; and Group C , was treated with Sodium Fluoride (NaF) ; group D , was treated with Artificial Saliva ( ASS ) , as control group . The specimens were then subjected to standardized pH cycling regime for 21 days. The( Diagnodent laser ) test was utilized to record the mineral profile in all groups ;the ( Spectrophotometer) test was used to evaluate the aesthetic effect of remineralizing agents , as well .the assessment was done in three stages ; (Baseline stage), (Lesion –creation stage) , and( after –remineralization stage) finally .The data were statistically analyzed using a two-way analysis of variance ( ANOVA) and Turkey’s post –hoc multiple comparison tests at a significance level of p<0.05.
Results Nano Silver Fluoride (NSF): Group B significantly increased the mineral profile and aesthetic appearance after artificial carious- like creation stage . As well as, Group B : Nano Silver Fluoride (NSF) reported the highest percentage change in mineral profile values and aesthetic appearance followed closely by Group A :Casein Phospho Peptide- Amorphous Calcium Phosphate (CPP-ACP) , and Group C: Sodium Fluoride (NaF) ; respectively the most predominant failure was in control group .
Conclusion Within this in-vitro study ; Nano Silver Fluoride( NSF) , and Casein Phospho Peptide- Amorphous Calcium Phosphate( CPP-ACP )containing dentifrice were effective in remineralizing lesions of enamel , as well as improving the aesthetic appearance . However, Sodium Fluoride (NaF) demonstrated less remineralization potential in comparison to dentifrices containing Nano Silver Fluoride (NSF) , and Casein Phospho Peptide- Amorphous Calcium Phosphate (CPP-ACP).
Investigation of fractographic study and fracture toughness in mode II of curved composites based on nano-silica/glass fiber thermoset matrix
Authors: Aslani Amir , Chamkouri Hossein 
Published: January 2023

Abstract
Increasing the qualities of composite materials that are connected to interlaminar fracture toughness and, as a result, delamination, is one of their greatest issues. The composite system demonstrated in this work is based on a curved glass fiber/nanosilica/epoxy resin samples with different precracked lengths from 30 mm to 60 mm and was created as a competitive alternative to the composites that are typically based on curved resin sanmpls in different industries such as areospace. Both composites were created using hand lay-up methods on a curved mold and 0/90 plain weave glass fiber fabric. Comparing the hybrid composites to glass fiber/epoxy composites, interlaminar fracture resistance was 30% higher in the hybrid composites. Because they have a propensity to absorb the energy associated with crack propagation in the form of plastic deformation, these materials have achieved exceptional performance in their resistance to crack propagation. As an additional tool for the mechanical characterization, the laminate's unidentified fractographic characteristics were utilized. In this case, the presence of morphological characteristics of pure Mode II shear failure was demonstrated, which are characterized by a failure directly in the surface fiber/matrix zones and shear edges that are comparable to the underlying determinant already demonstrated in epoxy resin matrices. Keywords: delamination, fractographic, deformation, mode II
The Event Related Potential Profiling of Consonants and Vowels Across Rule Learning Task Through Auditory Stimuli
Authors: KACHHAWA MINAL , Kumar Umesh , Patel Bhoopendra , Choudhary Ramesh Chand , Ganwani Dashrath , Dube Amitabh 
Published: January 2023

Abstract
The hypotheses that “consonants are preferentially used during lexical access” and “vowels trigger a response associated with learning rules of abstraction during the neural processing of language in a rule learning task” were evaluated and assessed by analysing patterned Event-Related Potentials (ERPs) [of early component(P50), mismatched negativity (MMN) and N400 waveforms] on presentation of trisyllabic auditory non-sense word stimuli of three consonant-vowel transitions (CVCVCV) rule in an oddball paradigm. The three stimuli engaged in the present study included standard stimuli of ABB rule (applicable on vowels in vowel condition and on consonants in consonant condition) and two deviant stimuli types were constructed of novel phonemes namely, phoneme deviant with same ABB rule but different phonemes and rule deviant of ABA exemplar along with different phonemes. The ERP response triggered by violation of rule implemented over consonants (across phoneme and rule deviant stimuli archetypal linguistics constructions) exhibited significant change in ERP profiling in amplitude and latency, when evaluated comparatively with that of standard stimuli and vowel condition generated significant ERP changes in both amplitude and latency only on rule deviant epitome (vis-à-vis standard stimuli). Such a selective and differential neural dynamical response in ERP profiles posits the fundamental underpinnings of unitary primal signatural constituents of neurolinguistics namely, vowels and consonants, with vowels initiating the process of abstraction of principle rule associated with neural processing of language and consonants commencing the process of lexicon access.
Ultrasonic-assisted synthesis of amino-functionalized Fe 3 O 4 @SiO 2 magnetic β- cyclodextrin nanocarrier for controlled release of doxorubicin anticancer drug
Authors: Hosseinzadeh Hossein , Jahanbakhsh Ziba , Masoumi Bakhshali , Hooshangi Vahid 
Published: January 2023

Abstract
β-cyclodextrin (β-CD) as cyclic oligosaccharide can be widely employed for preparation of controlled delivery of drugs. Hence, we synthesized a novel β-CD-based nanocarrier with superparamagnetic and molecular recognition properties for controlled release of doxorubicin (DOX) drug. The nanocarrier was prepared by using a facile ultrasonic-assisted method and through surface reversible addition fragmentation chain transfer (RAFT) copolymerization of core-shell Fe3O4@SiO2 nanoparticles onto vinylated β-CD. The spherical amino-functionalized Fe3O4@SiO2 nanomaterials were synthesized easily by a co-condensation green process of Fe3O4 nanoparticles with tetraethyl orthosilicate (TEOS) and (3-Aminopropyl) trimethoxysilane (APTES). The structure and composition of the as-prepared drug delivery nanocomposites were studied by FTIR, SEM, TEM, XRD, and VSM. Then, the loading and releasing behaviors of DOX drug have been investigated in detail. First of all, the loading of DOX was confirmed by UV-Vis spectra and SEM and TEM images of drug-loaded samples. The results also exhibited that the drug loading efficiency is found to be dependent on initial drug concentration, β-CD content and temperature. The drug loading capacity of nanocarrier was also compared with pure β-CD. Moreover, it was revealed that in vitro release rate of DOX was dependent on physiological solution pH. Finally, the drug release kinetics data were well fitted to the Higuchi model. In addition, biological characterizations were tested by MTT assay, which approved the high performance of the nanocarriers in killing cancerous cells. Due to its unique and distinct advantageous and properties, the synthesized nanocarriers can be utilized as a potential and promising biodegradable drug carrier for controlled and sustained release of various drugs.
scMINER: a mutual information-based framework for identifying hidden drivers from single-cell omics data
Authors: Yu Jiyang , Ding Liang , Shi Hao , Qian Chenxi , Burdyshaw Chad , Veloso Joao , Khatamian Alireza , Pan Qingfei , Dhungana Yogesh , Xie Zhen , Risch Isabel , Yang Xu , Huang Xin , Yan Lei , Rusch Michael , Brewer Michael , Yan Koon-Kiu , Chi Hongbo 
Published: January 2023

Abstract

The sparse nature of single-cell omics data makes it challenging to dissect the wiring and rewiring of the transcriptional and signaling drivers that regulate cellular states. Many of the drivers, referred to as "hidden drivers", are difficult to identify via conventional expression analysis due to low expression and inconsistency between RNA and protein activity caused by post-translational and other modifications. To address this issue, we developed scMINER, a mutual information (MI)-based computational framework for unsupervised clustering analysis and cell-type specific inference of intracellular networks, hidden drivers and network rewiring from single-cell RNA-seq data. We designed scMINER to capture nonlinear cell-cell and gene-gene relationships and infer driver activities. Systematic benchmarking showed that scMINER outperforms popular single-cell clustering algorithms, especially in distinguishing similar cell types. With respect to network inference, scMINER does not rely on the binding motifs which are available for a limited set of transcription factors, therefore scMINER can provide quantitative activity assessment for more than 6,000 transcription and signaling drivers from a scRNA-seq experiment. As demonstrations, we used scMINER to expose hidden transcription and signaling drivers and dissect their regulon rewiring in immune cell heterogeneity, lineage differentiation, and tissue specification. Overall, activity-based scMINER is a widely applicable, highly accurate, reproducible and scalable method for inferring cellular transcriptional and signaling networks in each cell state from scRNA-seq data.
The scMINER software is publicly accessible via: https://github.com/jyyulab/scMINER.