bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methodological considerations on segmenting rhabdomyosarcoma with diffusion-weighted imaging—What can we do better?
Authors: Chatziantoniou Cyrano , Schoot Reineke A. , van Ewijk Roelof , van Rijn Rick R. , ter Horst Simone A. J. , Merks Johannes H. M. , Leemans Alexander , De Luca Alberto 
Published: January 2023

Abstract
Purpose
Diffusion-weighted MRI is a promising technique to monitor response to treatment in pediatric rhabdomyosarcoma. However, its validation in clinical practice remains challenging. This study aims to investigate how the tumor segmentation strategy can affect the apparent diffusion coefficient (ADC) measured in pediatric rhabdomyosarcoma.

Materials and methods
A literature review was performed in PubMed using search terms relating to MRI and sarcomas to identify commonly applied segmentation strategies. Seventy-six articles were included, and their presented segmentation methods were evaluated. Commonly reported segmentation strategies were then evaluated on diffusion-weighted imaging of five pediatric rhabdomyosarcoma patients to assess their impact on ADC.

Results
We found that studies applied different segmentation strategies to define the shape of the region of interest (ROI)(outline 60%, circular ROI 27%), to define the segmentation volume (2D 44%, multislice 9%, 3D 21%), and to define the segmentation area (excludes edge 7%, excludes other region 19%, specific area 27%, whole tumor 48%). In addition, details of the segmentation strategy are often unreported. When implementing and comparing these strategies on in-house data, we found that excluding necrotic, cystic, and hemorrhagic areas from segmentations resulted in on average 5.6% lower mean ADC. Additionally, the slice location used in 2D segmentation methods could affect ADC by as much as 66%.

Conclusion
Diffusion-weighted MRI studies in pediatric sarcoma currently employ a variety of segmentation methods. Our study shows that different segmentation strategies can result in vastly different ADC measurements, highlighting the importance to further investigate and standardize segmentation.
Anti-inflammatory effect of taxifolin in TNF-α/IL-17A/IFN-γ induced HaCaT human keratinocytes
Authors: Park Jung Eun , Kwon Hee Jun , Lee Hwa Jin , Hwang Hyung Seo 
Published: January 2023

AbstractTaxifolin, a bioactive flavonoid, has been attracting attention as a beneficial and valuable phytochemical due to its antioxidant, anticancer, and anti-inflammatory properties. Recently, an improvement effect of taxifolin against psoriasis has been reported in an animal experimental model. However, its exact mechanism of action at molecular and cellular levels is not known. Thus, the purpose of this study was to verify the anti-inflammatory effect of taxifolin on psoriasis at cellular/molecular level using HaCaT human keratinocytes. First, a CCK-8 assay was performed to evaluate cytotoxicity of taxifolin. Results revealed that taxifolin was a relatively safe material, showing no cytotoxicity at concentrations up to 300 μg/mL. In TNF-α-induced HaCaT cells, taxifolin significantly inhibited mRNA expression levels of pro-inflammatory cytokines (IL-1α, IL-1-β, and IL-6) and chemokines (CXCL8 and CCL20). The ability of taxifolin to regulation expression of inflammatory cytokine genes was associated with phosphorylation of IκB/STAT3 protein. In addition, taxifolin inhibited expression levels of IL-1α/β, IL-6, CXCL8, and CCL20 by inhibiting IκB/STAT3 protein phosphorylation upon stimulation of TNF-α, IL-17A, and IFN-γ. These results show that taxifolin has the potential to be developed as a treatment for psoriasis and skin inflammation.
School bullying victimization and post-traumatic stress symptoms in adolescents: the mediating roles of feelings of insecurity and self-disclosure
Authors: Xu Yongyong , Ye Yingying , Zha Yichang , Zhen Rui , Zhou Xiao 
Published: January 2023

Abstract
Background
Posttraumatic stress symptoms (PTSSs) is known to be a typical problem for school bullying victims. However, the underlying mechanism between school bullying victimization and PTSSs remains unknown. This study examined the mediating roles of feelings of insecurity and self-disclosure in the relationship between school bullying victimization and PTSSs in adolescents.

Methods
Self-report questionnaires were used to assess 5013 adolescents; 443 of them with school bullying experiences were selected to carry out this study.

Results
The results found that school bullying victimization was directly related to more PTSSs, indirectly associated with more PTSSs through feelings of insecurity, and through the path from feelings of insecurity to self-disclosure. However, school bullying victimization did not exert an indirect effect on PTSSs through one step effect of self-disclosure.

Conclusions
These findings indicated that feelings of insecurity and self-disclosure mediated the relationship between school bullying victimization and PTSSs. The psychological service should reduce adolescents’ feelings of insecurity and give them more chances to disclose their bullying experiences.
Stretching the boundaries of cultural policies for inclusive and sustainable urban contexts: the case of Issy-les-Moulineaux in France
Authors: Moro Anna , Legale Eric 
Published: January 2023

AbstractCultural policies can be a strategic key to shaping more inclusive and sustainable urban regeneration processes, especially exploiting the acceleration promoted through transition dynamics. The City of Issy-les-Moulineaux, for its recent and deep investment in culture, sustainability and innovation in a non-conflictual and socially homogeneous urban dense context, is a valuable demonstrator of the role and forms in which institutional cultural policies at the urban scale can produce a shift of values, acceleration or simplification of decision-making processes towards inclusive and sustainable ways of life. The presentation of examples of cultural policies and regeneration programmes aims to contribute to the identification of some innovation trajectories in this direction, looking especially at the management of cultural policies or spaces and their flexibility and openness to inhabitants. Conclusions sketch the potential of strengthening some regime-niche traits of cultural policies in Issy and creating a permanent experimental environment in the governance (and approach) to cultural policies that reshape from rigid to fluid, thus increasing the anti-fragile nature of public policies and practices.
Rethinking Jacques-Louis David’s Marat assassiné through material evidences
Authors: Defeyt Catherine , Marechal Dominique , Vandepitte Francisca , Strivay David 
Published: January 2023

Abstract

Marat assassiné (Murdered Marat), one of the most famous masterpieces painted by Jacques-Louis David in 1793 has been investigated in situ by means of non-invasive and complementary analytical and imaging techniques. The overall material and technical information collected on this occasion led to important discoveries on the iconic picture of the French revolution. Following the identification of the palette used by David, we have shown the relationship between Marat assassiné and another David’s painting. Features of David’s artistic practice have been explained. Drastic changes in the final composition have been shown and explained based on scientific analysis and historical information. Finally we have formulated a hypothesis about how Marat assassiné could have been concealed.
Click-through rate prediction model integrating user interest and multi-head attention mechanism
Authors: Zhang Wei , Han Yahui , Yi Baolin , Zhang Zhaoli 
Published: January 2023

AbstractThe purpose of click-through rate (CTR) prediction is to anticipate how likely a person is to click on an advertisement or item. It's required for a lot of internet applications, such online advertising and recommendation systems. The previous click-through rate estimation approach suffered from the following two flaws. On the one hand, input characteristics (such as user id, user age, user age, item id, item category) are usually sparse and multidimensional, making them effective. High-level combination characteristics are used for prediction. Obtaining it manually by domain experts takes a long time and is difficult to finish; also, customer interests are not all the same. The accuracy of the model findings will significantly increase if this immediately recognized component is incorporated in the prediction model. As a consequence, this study creates an IARM (interactive attention rate estimation model) that incorporates user interest as well as a multi-head self-attention mechanism. The deep learning network is used in the model to determine the user's interest expression based on user attributes. The multi-head self-attention mechanism with residual network is then employed to get feature interaction, which enhances the degree of effect of significant characteristics on the estimation result as well as its accuracy. The IARM model outperforms other recent prediction models in the assessment metrics AUC and LOSS, and it has superior accuracy, according to the results from the public experimental data set.
Covid-19 outbreak and beyond: a retrospect on the information content of short-time workers for GDP now- and forecasting
Authors: Kaufmann Sylvia 
Published: January 2023

AbstractWe document whether a simple, univariate model for quarterly GDP growth is able to deliver forecasts of yearly GDP growth in a crisis period like the Covid-19 pandemic, which may serve cross-checking forecasts obtained from elaborate and expert models used by forecasting institutions. We include shocks to the log number of short-time workers as timely available current-quarter indicator. Yearly GDP growth forecasts serve cross-checking, in particular at the outbreak of the pandemic.
Characterization and field evaluation of Spilosoma obliqua nucleopolyhedrosis virus (SpobNPV) CRIJAF1 strain against jute hairy caterpillar, Spilosoma obliqua (Walker) infesting jute, Corchorus olitorius Linn.
Authors: Babu Veegala Ramesh , Sivakumar G. , Satpathy S. 
Published: January 2023

Abstract
Background
Spilosoma (= Spilarctia) obliqua (Walker) (Lepidoptera: Arctiidae), once considered as a sporadic pest, is now considered as a major and polyphagous pest widely distributed throughout India. Recent outbreaks of this pest were manifested in both jute and sunnhemp. During a survey in and around adjoining villages of I.C.A.R-C.R.I.J.A.F, Barrackpore, an epizootic was observed in the field population of S. obliqua caused by a nucleopolyhedrosis virus. Hence, an attempt was made to isolate, characterize using electron microscopy and assess the efficacy of S. obliqua nucleopolyhedrosis virus under laboratory and field conditions.

Results
Electron microscopic studies revealed typical baculovirus occlusion bodies of type nucleopolyhedrosis virus with tetrahedral and triangular in shape with the size ranging from 2.55 to 2.90 µm, with an average size of about 2.72 µm. Bioassay studies showed the larval mortality at low concentration of SpobNPV, i.e., 2.42 × 104 POBs/ml. The virus-infected S. obliqua was identified through the amplification of polyhedrin, polh gene sequences with the available sequences in public database, GenBank, NCBI. The sequence data generated for the polyhedrin gene were deposited in GenBank, and accession number was obtained, MN648213. Field experiment revealed 50.52, 63.25 and 82.91% larval reductions, respectively, at 2, 4 and 7 days after spray of S. obliqua nucleopolyhedrosis virus.

Conclusion
The present study revealed that foliar application of S. obliqua nucleopolyhedrosis virus was very effective in causing mortality against S. obliqua larvae and thus can be used as an effective microbial bioagent in the integrated pest management of the caterpillar, S. obliqua.
Diffusion tensor magnetic resonance imaging in differentiation of breast lesions
Authors: Amin Esraa Saleh , Elsharawy Fatma Anas , Mlees Mohamed Ali , EL-Saeid Haytham Haroun , Dawoud Mohammed Fathy 
Published: January 2023

Abstract
Background
Diffusion tensor imaging (DTI) is a novel approach which uses extra gradients to quantify diffusion in several directions (at least six). The purpose of this research was to determine the role of diffusion tensor magnetic resonance imaging in breast lesion differentiation.

Results
Apparent diffusion coefficient (ADC) values were significantly lower in malignant than benign lesions, with a cut-off value of 1.21 × 10−3 mm2/s, this gives a sensitivity of 88.46%, specificity 87.50% and accuracy 86.7%. Values of fractional anisotropy (FA) were higher significantly in malignant compared to benign lesions with a 0.15 cut-off value, has a 95.83% sensitivity, 96.15% specificity, and 95.6%, accuracy. Values of RA were significantly higher in malignant (0.180 ± 0.068) compared to benign lesions, with 0.13 cut-off value. Sensitivity, specificity, and accuracy were, respectively, 91.69%, 92.31%, and 90.2%. Values of λ1 were significantly lower in malignant (1.4 ± 0.453 × 10−3 mm2/s) than in benign (2.19 ± 0.659 × 10−3 mm2/s) lesions with a cut-off value of 1.71 × 10−3 mm2/s. Sensitivity and specificity were, respectively, 95.83 and 96.15%. The combined evaluation by (dynamic contrast enhancement) Sensitivity improved to 100% with DCE and DTI readings, while specificity remained at 95.6%.

Conclusions
DTI breast imaging is a noninvasive procedure which demonstrated a high potential utility for cancer detection and serving as a standalone technique or in conjunction with DCE-MRI, the discriminating values of FA, λ1 and λ1–λ3 were high. Their measurements were strongly associated with identification breast malignancy and combined evaluation by DTI parameters and DCE-MRI DTI enhanced the sensitivity, lowered the rate of false-negatives, and completely improved the accuracy of breast lesions differential diagnosis.
Diagnostic challenge of dyspnea in the context of the COVID-19 pandemic wave: a case report
Authors: Razafindrasoa Zamelina Angela , Razafimpihanina Sonia Marcelle , Rasoafaranirina Marie Odette , Martin Fidy Arnauld , Andriamahenina Finaritra Princy Parfait , Andriarimanga Diamondra Ombanjanahary , Rakotomizao Jocelyn Robert , Tiaray Harison Michel , Rakotoson Joëlson Lovaniaina , Raharimanana Rondro Nirina 
Published: January 2023

Abstract

Background
Since its discovery, COVID-19 has often been the first diagnosis of dyspnea and asthenia, especially during the pandemic waves. However, it is not always COVID-19. We report a particular case of a late-diagnosed HIV-positive patient in Madagascar.

Case presentation
A 21-year-old male patient was admitted to a hospital center in Antananarivo for dyspnea and poor general condition. Physical examination revealed hypoxemia of 85% on room air. His chest X-ray showed bilateral reticular-micronodular opacities. He was suspected and treated for COVID-19. On the 15th day of hospitalization, HIV-1 infection complicated by probable pneumocystis was diagnosed. On the other hand, a multimetastatic testicular cancer was also suspected. The patient died after a few hours of hospitalization in the intensive care unit.

Conclusion
This was a case of an HIV-positive patient belatedly diagnosed in the complications stage during the COVID-19 pandemic wave. The investigation of the differential diagnoses remains crucial to avoid serial misdiagnosis and to adjust therapeutic management.
Historical imaginaries, historic urban branding, and the local state in China: rejuvenation discourse, manufactured heritage and simulacrascapes
Authors: Law Andrew Malcolm 
Published: January 2023

AbstractThis intervention examines the extant literature on historical imaginaries and historic urban branding in China. It suggests that while research in this field has increasingly moved away from an economic (or an implicit neo-Marxist) model, there is still a lack of research on the role of broader cultural and state led discourses of nationalism in the construction of historic urban imaginaries and historic urban branding within Chinese cities. In unpacking one nationalistic discourse a – narrative of rejuvenation – this article argues that more needs to be done to examine the role of these themes in the construction of historical imaginaries at the level of the local state (including related state networks of developers, retailers, tourist officials, town planners, architects, and designers). It is suggested that an analysis of these discourses and imaginaries is important if we are: 1) to appreciate the role of these themes in the construction and/or the reconfiguration of existing or emerging historic brands within Chinese cities; 2) to comprehend the construction of ‘authorised heritage discourses’, (AHDs) practices and materialities at the level of the local state; 3) to understand the politics of the past (including the uses of history, memory, nostalgia, and heritage) at the level of the local state; 4) to be aware of the way in which these themes inform the preservation, conservation, and/or the demolition of heritage space at the level of the local state; 5) to recognise the manufacture of ‘heritage’ or simulacrascapes within Chinese cities.
Semantic dementia: a complex and culturally influenced presentation
Authors: Cole Richard H. , Clark Camilla N. , Poole Norman A. 
Published: January 2023

SummaryThe variants of frontotemporal dementia (FTD) require careful differentiation from primary psychiatric disorders as the neuropsychiatric manifestations can overshadow the unique cognitive deficits. The language variants of FTD are less readily recognised by trainees despite making up around 43% of cases.1 This educational article presents an anonymised case of one of the language variants: semantic dementia. The cognitive deficits and neuropsychiatric manifestations (delusions and hyperreligiosity) are explored in terms of aetiology and management. By the end of the article, readers should be able to differentiate FTD from Alzheimer's disease, understand the principles of management and associated risks, and develop a multifaceted approach to hyperreligiosity in dementia.
Correlation between abnormal brain network activity and electroencephalogram microstates on exposure to smoking-related cues
Authors: Gan Hefan , Bu Junjie , Zeng Ginger Qinghong , Gou Huixing , Liu Mengyuan , Cui Guanbao , Zhang Xiaochu 
Published: January 2023

Background
Research into neural mechanisms underlying cue-induced cigarette craving has attracted considerable attention for its significant role in treatments. However, there is little understanding about the effects of exposure to smoking-related cues on electroencephalogram (EEG) microstates of smokers, which can reflect abnormal brain network activity in several psychiatric disorders.

Aims
To explore whether abnormal brain network activity in smokers on exposure to smoking-related cues would be captured by EEG microstates.

Method
Forty smokers were exposed to smoking and neutral imagery conditions (cues) during EEG recording. Behavioural data and parameters for microstate topographies associated with the auditory (A), visual (B), salience and memory (C) and dorsal attention networks (D) were compared between conditions. Correlations between microstate parameters and cigarette craving as well as nicotine addiction characteristics were also analysed.

Results
The smoking condition elicited a significant increase in the duration of microstate classes B and C and in the duration and contribution of class D compared with the neutral condition. A significant positive correlation between the increased duration of class C (smoking minus neutral) and increased craving ratings was observed, which was fully mediated by increased posterior alpha power. The increased duration and contribution of class D were both positively correlated with years of smoking.

Conclusions
Our results indicate that smokers showed abnormal EEG microstates when exposed to smoking-related cues compared with neutral cues. Importantly, microstate class C (duration) might be a biomarker of cue-induced cigarette craving, and class D (duration and contribution) might reflect the relationship between cue-elicited activation of the dorsal attention network and years of smoking.
Loss of Independent Living in Patients Undergoing Transcatheter or Surgical Aortic Valve Replacement: A Retrospective Cohort Study
Authors: Blank Michael , Robitaille Mark J. , Wachtendorf Luca J. , Linhardt Felix C. , Ahrens Elena , Strom Jordan B. , Azimaraghi Omid , Schaefer Maximilian S. , Chu Louis M. , Moon Jee-Young , Tarantino Nicola , Nair Singh R. , Thalappilil Richard , Tam Christopher W. , Leff Jonathan , Di Biase Luigi , Eikermann Matthias 
Published: January 2023

BACKGROUND:
The recommendation for transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) in patients 65 to 80 years of age is equivocal, leaving patients with a difficult decision. We evaluated whether TAVR compared to SAVR is associated with reduced odds for loss of independent living in patients ≤65, 66 to 79, and ≥80 years of age. Further, we explored mechanisms of the association of TAVR and adverse discharge.

METHODS:
Adult patients undergoing TAVR or SAVR within a large academic medical system who lived independently before the procedure were included. A multivariable logistic regression model, adjusting for a priori defined confounders including patient demographics, preoperative comorbidities, and a risk score for adverse discharge after cardiac surgery, was used to assess the primary association. We tested the interaction of patient age with the association between aortic valve replacement (AVR) procedure and loss of independent living. We further assessed whether the primary association was mediated (ie, percentage of the association that can be attributed to the mediator) by the procedural duration as prespecified mediator.

RESULTS:
A total of 1751 patients (age median [quartiles; min–max], 76 [67, 84; 23–100]; sex, 56% female) were included. A total of 27% (222/812) of these patients undergoing SAVR and 20% (188/939) undergoing TAVR lost the ability to live independently. In our cohort, TAVR was associated with reduced odds for loss of independent living compared to SAVR (adjusted odds ratio [ORadj] 0.19 [95% confidence interval {CI}, 0.14–0.26]; P < .001). This association was attenuated in patients ≤65 years of age (ORadj 0.63 [0.26–1.56]; P = .32) and between 66 and 79 years of age (ORadj 0.23 [0.15–0.35]; P < .001), and magnified in patients ≥80 years of age (ORadj 0.16 [0.10–0.25]; P < .001; P-for-interaction = .004). Among those >65 years of age, a shorter procedural duration mediated 50% (95% CI, 28–76; P < .001) of the beneficial association of TAVR and independent living.

CONCLUSIONS:
Patients >65 years of age undergoing TAVR compared to SAVR had reduced odds for loss of independent living. This association was partly mediated by shorter procedural duration. No association between AVR approach and the primary end point was found in patients ≤65 years of age.