bluuebunny/crossref_metadata_2025_split huggingface dataset:
НЕФОРМАЛЬНА ОСВІТА: ОСОБИСТІСНА Й ПРОФЕСІЙНА СПРЯМОВАНІСТЬ ТА СТАВЛЕННЯ СТУДЕНТІВ-СТОМАТОЛОГІВ
Authors: ЄФРЕМОВА Оксана , ГУМЕНЮК Ольга , ЦЮРА Світлана , ГУМЕНЮК Василь 
Published: July 2023

Узагальнено, що здобуття неформальної освіти студентами стоматологами має низку особливостей, серед яких інформаційна насиченість основної освіти, технологічна складність сучасних стоматологічних послуг, висока вартість освітніх програм для стоматологів.
Аналіз поінформованості студентів щодо неформальної освіти проведений за результатами анкетування у Львівському національному медичному університеті імені Данила Галицького, Івано-Франківському національному медичному університеті, Львівському медичному університеті, Тернопільському національному медичному університеті імені І. Я. Горбачевського. Виявлено, що 62% опитаних студентів не здобувають неформальну освіту. Щодо їх поінформованості про ресурси неформальної освіти ми отримали збіг в усіх трьох групах стейкхолдерів – студентів, викладачів, роботодавців. Як пріоритетні обрано ресурси: Prometheus, Coursera, Udemy, edX.org, Khan Academy, navychka. З тих студентів, які користуються електронними ресурсами неформальної освіти лише 13,6% виділяють понад чотири години на тиждень.
Спрямованість студентів розглянута за пріоритетною до освітньої діяльності мотивацією, зорієнтованість на: самовдосконалення себе; професійне самовдосконалення; спілкування і взаємодію, розширення свого соціального простору. Виявлено перевагу чотирьох пріоритетів: 50% визначили, що метою здобуття освіти є вдосконалення знань та вмінь за напрямом навчання, 36% – особистісний розвиток, 30% – здобуття вмінь та навичок поза напрямом навчання; 27% – розширення сфери спілкування. Важливим показником для характеристики спрямованості стало визначення бажаної тематики програм неформальної освіти: 40,5% учасників опитування обрали бізнес та підприємництво. Щодо критеріїв важливих у виборі, то 66% обрали гнучкий графік навчання, 54% – співвідношення ціни навчання і його потенційної корисності; 36% – особисто привабливі програми.
Cardiovascular Risk Assessment in Type 2 Diabetic Patients at Universitas Sumatera Utara Hospital
Authors: Faza Ulya Putri  , Naomi Niari Dalimunthe  , Ginting Andi Raga , Isti Ilmiati Fujiati  
Published: July 2023

Background. Diabetes is a major health problem worldwide including in Indonesia. There is a close relationship between diabetes and cardiovascular disease, with cardiovascular events being the most prevalent cause of morbidity and mortality in diabetic patients. Therefore, it is important to assess cardiovascular risk in patients with diabetes in order to conduct appropriate preventive strategies. Various methods have been developed to assess the degree of cardiovascular risk, one of which is the Jakarta Cardiovascular Score, a scoring method that has been adapted for the Indonesian community. This study aims to describe the profile of cardiovascular risk in diabetes patients at Universitas Sumatera Utara Hospital.
Methods. A descriptive, cross-sectional study was conducted in the internal medicine outpatient clinic at Universitas Sumatera Utara Hospital. All subjects were diabetic patients who had not developed any cardiovascular complications. The risk of cardiovascular disorders was assessed using the Jakarta Cardiovascular Score. Data were collected through medical records, interviews, and physical examinations.
Results. There were 64 subjects in this study. The majority of subjects (81.3%) were classified as high risk for cardiovascular disease.
Conclusion. Most patients with diabetes have a high degree of risk of cardiovascular disease.
Restricción jurisprudencial para ejercer la cláusula de interpretación conforme (el caso de la restricción contenida en la fracción XIII del apartado b del artículo 123 constitucional).
Authors: Guzmán Robledo María Teresa 
Published: July 2023

La presente investigación tiene como finalidad el estudio desde la perspectiva de los Derechos Humanos, del incumplimiento de la cláusula de interpretación conforme consagrada en el artículo 1° constitucional, en virtud de las determinaciones jurisprudenciales emitidas por el máximo Tribunal del estado mexicano, respecto de la restricción contenida en la fracción XIII del artículo 123 de la Constitución Política de los Estados Unidos Mexicanos.
Para demostrarlo se utiliza un método hipotético- deductivo y el método interpretativo, que permita analizar la fenómeno jurídico, su origen, determinación e interpretación, lo anterior desde la legislación, la doctrina jurídica y diversas sentencias en materia de amparo (como marco empírico), lo que permitirá estudiar el origen de la clausule de interpretación conforme a través de su herramienta hermenéutica “el principio pro persona”, las determinaciones jurisprudenciales de su alcance y las restricciones que han afectado a un sector específico, siendo estos los Policías, Ministerios Públicos, etc.
Motivational Factors on the Use of Mobile Food Delivery Services in Lapu-Lapu City, Cebu, Philippines
Authors: ESGUERRA JAMES GARCIA , Payao Analiza A. , Capitan Nena M. , Caballes Vanessa Sofia , Queriado Mary Joy , Razon Chennie Pearl , Cañete Ma. Theres , Dagatan Cathleen Claire Dagatan 
Published: July 2023

The study investigates the motivational factors that influence customers on the use of mobile food delivery services. The study utilized a descriptive method to describe the factors that influence customers to use the mobile food application. A total of 100 response was garnered by the study. In addition to the survey, the study also presented the ASEAN development on the use of the application, it was observed that this emerging business model contributed to the gross merchandise value. In the context of the Philippines, it was found that it is already a growing business model that provided an avenue for the food and beverage industry to thrive during the pandemic. The results of the survey also showed that the identified factors were very influential in the decision of the customers to use the application. Further study is recommended using other indicators and approaches to have a better understanding of the use of mobile food delivery applications.
Nexus Between Social Dimension and Financial Performance: a Bidirectional Study of the Nigerian Banking Industry
Authors: Olateju Dare John , Olateju Olakunle Abraham 
Published: July 2023

The study of CSR is gaining prominence because it is a critical component of business strategy that cannot be downsized due to its continued relevance to critical environmental, social, and governance impacts on our present world. The article mirrors the CSR implementation of Nigerian banks and its implication on their financial performance through the lens of legitimacy theory and vice versa. To know the financial indicator that determines the level of CSR performance. A panel data design was used to collect, arrange and analyse data. In other to regress the relationship between the social dimension of CSR and financial performance, we regress social dimension with PAT, EPS, and ROA using multivariate linear regression after taking into consideration all the relevant assumptions. The findings reveal that the social dimension has a positive relationship with PAT, EPS, and ROA. While social dimension shows a significant relationship between PAT and EPS but no significant relationship with ROA. PAT appeared to be a better predictor among the three financial predictors considered. To increase earnings, the findings suggest that firms can increase their social spending. As a single-case study, the findings may not be adequate for theoretical generalizations and therefore limited to the context of the study. This study adds to and expands the assumptions of legitimacy theory constructs by rethinking and exploring new assumptions in the context of the social dimension of CSR within the context of a developing country. It brings the theory to practice on strategic use of social dimension
Cu-doped polypyrrole hydrogel with tumor catalyst activity for NIR-II thermo-radiotherapy
Authors: Wang Shile , Fei Haotian , Ma Yuhong , Zhu Daoming , Zhang Hongtao , Li Xiang , Huang Qinqin 
Published: July 2023

Introduction: Radiotherapy (RT) is one of the key methods for treating breast cancer. However, the effect of single RT is often poor because of insufficient deposition of X-rays in tumor sites and radiation resistance induced by the abnormal tumor microenvironment (overexpression of glutathione (GSH)). The development of multifunctional RT sensitizers and synergetic therapeutic strategies is, therefore, a promising area for enhancing the anticancer effect of RT.Methods: In this study, a multifunctional nanozyme hydrogel based on Cu-doped polypyrrole (CuP) was designed to work concertedly with a second near-infrared thermal RT. The CuP-based hydrogel (CH) reached the tumor site when injected in-situ and achieved long-term storage.Results: Once stimulated with 1064-nm laser irradiation, the heated and softened hydrogel system released CuP nanozyme to provide photothermal therapy, thereby inhibiting the repair of DNA damage caused by RT. In addition, CuP with dual nanozyme activity depleted the intracellular GSH to reduce the antioxidant capacity of the tumor. Moreover, CuP converted H2O2 to produce ·OH to directly kill the tumor cells, thus enhancing the capability of low-dose RT to inhibit tumor growth. In vivo experiments showed that the CH system used in combination with a low-power 1064-nm laser and low-dose RT (4 Gy) exhibited good synergistic anticancer effects and biological safety.Discussion: As a new light-responsive hydrogel system, CH holds immense potential for radio-sensitization.
Development of an antibacterial polypropylene/polyurethane composite membrane for invisible orthodontics application
Authors: Yang Feng , Wu Chenyi , Jiang Yuanzhang , Tan Lin , Shu Rui 
Published: July 2023

In virtue of the advantages, such as aesthetics, designability, convenient removal, and comfortable experience, invisible orthodontics (IO) have been widely recognized and accepted by the public. However, most of the membranes currently used for IO only meet the requirement of shape retention. Other vital functions, like antibacterial and antifouling activities, are neglected. Herein, antibacterial composite membranes (ACMs) containing polypropylene (PP), thermoplastic polyurethane (TPU) and poly (hexamethylene guanidine) hydrochloride-sodium stearate (PHMG-SS) were facilely manufactured through the hot-pressing membrane forming technology. ACMs were conferred with favorable transparency (∼70% in the visible light range) and excellent antibacterial ability. Experiment results demonstrated that bactericidal rates of ACMs against Staphylococcus aureus, Escherichia coli and Streptococcus mutans were larger than 99.99%. Noticeably, the amount of protein adhered on the surface of ACMs was only 28.1 μg/cm2, showing ideal antifouling performance. Collectively, the mutifunctional ACMs in the study are expected to be prominent alternatives for existing IO.
The interplay of common genetic variants NRG1 rs2439302 and RET rs2435357 increases the risk of developing Hirschsprung’s disease
Authors: Chi Shuiqing , Li Shuai , Cao Guoqing , Guo Jialing , Han Yunqiao , Zhou Yun , Zhang Xi , Li Yibo , Luo Zhibin , Li Xiangyang , Rong Liying , Zhang Mengxin , Li Linglu , Tang Shaotao 
Published: July 2023

Introduction: As a congenital and genetically related disease, many single nucleotide polymorphisms (SNPs) have been reported to be associated with the risk of HSCR. Our previous research showed that SNP rs2439302 (NRG1) interacted with rs2435357 (RET) to increase the risk of HSCR development. However, the underlying molecular mechanism is still not well understood.Methods: SNP rs2439302 (NRG1) and rs2435357 (RET) were genotyped in 470 HSCR cases. The expression of NRG1 and RET was investigated in the colon of HSCR patients. Knockdown of the NRG1 and RET homologs was performed in zebrafish to investigate their synergistic effect on ENS development. The effect of SNP rs2439302 and rs2435357 polymorphism on neuron proliferation, migration, and differentiation were investigated in SHSY-5Y cells and IPSCs.Results: Significant downregulation of NRG1 and RET expression was noticed in the aganglionic segment of HSCR patients and SHSY-5Y cells with rs2439302 GG/rs2435357 TT genotype. NRG1 and RET double mutants caused the most severe reduction in enteric neuron numbers than NRG1 single mutant or RET single mutant in the hindgut of zebrafish. SHSY-5Y cells and IPSCs with rs2439302 GG/rs2435357 TT genotype exhibited a decreased proliferative, migration, and differentiative capacity. CTCF showed a considerably higher binding ability to SNP rs2439302 CC than GG. NRG1 reduction caused a further decrease in SOX10 expression via the PI3K/Akt pathway, which regulates RET expression by directly binding to rs2435357.Discussion: SNP rs2439302 (NRG1) GG increases the risk of developing HSCR by affecting the binding of transcription factor CTCF and interacting with rs2435357 (RET) to regulate RET expression via the PI3K/Akt/SOX10 pathway.
Outcomes of covered stents versus bare-metal stents for subclavian artery occlusive disease
Authors: Wei Libing , Gao Xixiang , Tong Zhu , Cui Shijun , Guo Lianrui , Gu Yongquan 
Published: July 2023

ObjectiveTo compare the clinical efficacy of covered stents and bare-metal stents in the endovascular treatment of subclavian artery occlusive disease.MethodsBetween January 2014 and December 2020, 161 patients (112 males) underwent stenting of left subclavian arteries; CSs were implanted in 55 patients (34.2%) and BMSs in 106 (65.8%). Thirty-day outcomes, mid-term patency, and follow-up results were analyzed with Kaplan-Meier curves. Relevant clinical, anatomical, and procedural factors were evaluated for their association with patency in the two groups using Cox proportional hazards regression.ResultsMean follow-up was 45 ± 18 months. The primary patency was 93.8% (95% CI, 81.9%–98.0%) in the covered stent group and 73.7% (95% CI, 63.2%–81.6%; P = 0.010) in the bare-metal stent group. The primary patency in the total occlusion subcategory was significant in favor of CS (93.3%, 95% CI, 61.26%–99.0%) compared with BMS (42.3%, 95% CI, 22.9%–60.5%; P = 0.005). Cox proportional hazards regression indicated that the use of BMSs [hazard ratio (HR), 4.90; 95% CI, 1.47–16.31; P = 0.010] and total occlusive lesions (HR, 7.03; 95% CI, 3.02–16.34; P &lt; 0.001) were negative predictors of patency, and the vessel diameter (HR, 3.17; 95% CI, 1.04–9.71; P = 0.043)) was a positive predictor of patency.ConclusionCompared with bare stents, covered stents have a higher midterm primary patency in the treatment of subclavian artery occlusive disease.
Systemic immune-inflammation index is associated with coronary heart disease: a cross-sectional study of NHANES 2009–2018
Authors: Ma Jiwen , Li Ka 
Published: July 2023

BackgroundInflammation has been linked to the development of coronary heart disease (CHD). The systemic immune inflammation index (SII) is a useful biomarker of systemic inflammation. Our study aimed to explore the correlation between SII and CHD.MethodsWe conducted a multivariate logistic regression analysis, smoothing curve fitting, and segmented model comparison on 15,905 participants with a CHD prevalence of 3.31% and a mean age of 46.97 years.ResultsAdjusting for gender, age, and race, we found a negative association between SII and CHD [odds ratio (OR) 0.66; 95% confidence interval (CI) 0.48, 0.90]. There was an inverse trend where increasing SII was associated with decreasing odds of CHD (p for trend = 0.0017). After further adjustment, the association was strengthened, with a similar trend (p for trend = 0.0639). Smoothing curve fitting demonstrated a gender-specific association between SII and CHD.ConclusionsOur findings suggest that higher SII values may be associated with a higher incidence of CHD, which varies by gender. SII may be a cost-effective and convenient method to detect CHD. Further studies are needed to confirm the causality of these findings in a larger prospective cohort.
A non-linear relationship between triglyceride glucose waist circumference and nonalcoholic fatty liver disease in a Japanese population: a secondary analysis
Authors: He Xiaojie , Huang Xinyue , Qian Yafang , Sun Ting 
Published: July 2023

IntroductionNonalcoholic fatty liver disease (NAFLD) is a common metabolic disorder associated with insulin resistance (IR). Triglyceride glucose waist circumference (TyG-WC) is a novel index of IR that reflects both visceral fat and hepatic steatosis. However, it is not known whether TyG-WC and NAFLD exhibit a nonlinear relationship in Japanese subjects with normal plasma glucose level. Thus, we examined the relationship between TyG-WC and NAFLD, in addition to determining the threshold level of TyG-WC associated with NAFLD.MethodsA secondary analysis was performed based on a previous study that extracted medical examination records from Murakami Memorial Hospital between 2004 and 2015 in order to detect chronic diseases and their risk factors. TyG-WC was determined at baseline. NAFLD is the dependent variable. Univariate and multivariate logistic regression models were used to evaluate the risk of NAFLD incidence. Based on the smoothing plot, a two-piecewise linear regression model was used to examine the threshold effect of TyG-WC on NAFLD. A subgroup analysis was carried out in order to study other factors that may influence the association between TyG-WC and NAFLD.Results14,280 met the criteria for inclusion in the current secondary analysis. The adjusted OR (95% CI) for NAFLD in all subjects was 1.007 (95% CI 1.006–1.009, P &lt; 0.001). The relationship between TyG-WC and NAFLD in Japanese subjects with normal plasma glucose level is nonlinear. TyG-WC is positively associated with NAFLD when TyG-WC is ranged between 480 and 800. In subgroup analyses, there was a significant interaction between BMI and TyG-WC associated NAFLD risk (P for interaction &lt;0.001).DiscussionThe relationship between TyG-WC and NAFLD is nonlinear. TyG-WC is positively associated with NAFLD when TyG-WC is ranged between 480 and 800. There is potential clinical significance for the TyG-WC in identifying groups at high risk for NAFLD in subjects with normal plasma glucose level.
Assessing ecotoxicity of an innovative bio-based mulch film: a multi-environmental and multi-bioassay approach
Authors: Barbir J. , Arato E. , Chen C-Y. , Granberg M. , Gutow L. , Krång A-S. , Kröger S. D. , Leal Filho W. , Liwarska-Bizukojc E. , Miksch L. , Paetz K. , Prodana M. , Saborowski R. , Silva Rojas R. , Witt G. 
Published: July 2023

Among the highly diverse range of biobased polymers, polylactic acid (PLA) received vast attention in recent years due to its versatility for different applications and being the first commercially used polymer produced from renewable sources. Production and application of bio-based, biodegradable plastics will have one of the most crucial roles in tackling worldwide plastic pollution.Methods: This study is based on integrative ecotoxicological assessment of an innovative PLA-based agricultural mulch film (BPE-AMF-PLA), developed under the H2020 EU project “BIO-PLASTICS EUROPE”, towards organisms from different environmental compartments (soil, fresh water and marine) and from different trophic levels. Such comprehensive evaluation has an overarching goal to promote environmentally safe and sustainable use of these PLA-based plastics for agricultural and other potential applications.Results: Low-to-no phytotoxicity was obtained in both single-species standardized bioassays, and in a multi-species microcosms experiment. Earthworm reproduction was negatively affected at the lowest test concentration of 0.1% w/w of PLA-based plastic particles. For freshwater Daphnia, reproduction was found a sensitive endpoint, upon exposure to the leachates of the PLA-based plastic. However, the reported toxicity seemed to be caused by the presence of 2-methylnaphthalene, which can be avoided in the production process. As for the marine organisms, algae growth was inhibited with a LOEC = 25 g L−1, whereas test with brine shrimp only revealed stimulation of lipase upon digestion of micro-sized PLA-based plastics. Marine lugworm ingested pristine and UV pre-treated micro-sized plastics, yet without impact either on biological activity, or on the health of the test individuals.Discussion: The approach used in the present work will contribute to product development, environmental safety and sustainable applications of the PLA-based mulch film BPE-AMF-PLA, in the scope of project BIO-PLASTICS EUROPE. Furthermore, the tools and results obtained in this work are a relevant contribution in the framework development for additional support in the certification of the bio-based polymers, being aligned with European zero waste and non-toxicity strategies, certification, and regulations.
Warming promoted CH4 absorption compared with precipitation addition in typical steppe in Inner Mongolia
Authors: Chen Xuemeng , Wan Zhiqiang , Gu Rui , Ganjurjav Hasbagan , Hu Guozheng , Gao Qingzhu , Chun Xi , Zhou Haijun , Hai Chunxing 
Published: July 2023

IntroductionClimate change, characterized by rising temperatures and changing precipitation patterns, has emerged as a significant global concern. Particularly, the warming potential of CH4 is 28 times greater than that of CO2, leading to an increased focus on its impact. Among various ecosystems, grasslands exhibit a high vulnerability to climate change. Grassland in Inner Mongolia is an important component of the typical grassland in Eurasian, and there was evidence that warmer and more precipitation in this area in future.MethodsIn this study, we utilized an open-top chamber (OTC) to conduct warming and precipitation experiments on a representative steppe located in Inner Mongolia in 2011. From 2017 to 2019, we monitored various factors, including soil temperature, moisture, CH4 flux, community characteristics, soil carbon nitrogen content. Subsequently, we analyzed the response of CH4 flux and its influencing factors to warming and precipitation in this typical steppe.ResultsThe soil in the typical steppe acted as a CH4 sink. In 2018, CH4 flux during the growing season and t during the non-growing season were −59.31 and −21.21 under C, −56.55 and −31.17 under T, −41.34 and −24.93 under P, −50.09 and −26.51 ug C·m−2·h−1 under TP respectively. Warming stimulated absorption of CH4 during the non-growing season (25.8%), while the addition of precipitation hindered CH4 absorption during the growing season (76.37%). Warming and precipitation addition decreased the percentage of CH4 absorbed in growing season and increased that in non-growing season which account 67.66% and 32.34% under C, 59.81% and 40.19% under T, 62.71% and 37.29% under P, 62.03% and 37.97% under TP respectively. Soil temperature exhibited a positive correlation with CH4 flux (P&lt;0.001), while the dominance of Leymus chinensis (IV-L.c.) exhibited a negative correlation with CH4 flux (P&lt;0.01). Moreover, NH4+-N displayed a positive correlation with CH4 flux (P&lt;0.05).ConclusionThe findings suggest that CH4 absorption in a typical steppe may increase in a warmer future, and warming is conducive to the absorption of CH4 in the non-growing season. Not only abiotic factors had an impact on CH4 absorption, but also changes in community composition. Consequently, further exploration of the underlying mechanisms is warranted.