bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deacetylase‐dependent and ‐independent role of HDAC3 in cardiomyopathy
Authors: Ren Jieyu , Zeng Qun , Wu Hongmei , Liu Xuewen , Guida Maria C. , Huang Wen , Zhai Yiyuan , Li Junjie , Ocorr Karen , Bodmer Rolf , Tang Min 
Published: February 2023

AbstractCardiomyopathy is a common disease of cardiac muscle that negatively affects cardiac function. HDAC3 commonly functions as corepressor by removing acetyl moieties from histone tails. However, a deacetylase‐independent role of HDAC3 has also been described. Cardiac deletion of HDAC3 causes reduced cardiac contractility accompanied by lipid accumulation, but the molecular function of HDAC3 in cardiomyopathy remains unknown. We have used powerful genetic tools in Drosophila to investigate the enzymatic and nonenzymatic roles of HDAC3 in cardiomyopathy. Using the Drosophila heart model, we showed that cardiac‐specific HDAC3 knockdown (KD) leads to prolonged systoles and reduced cardiac contractility. Immunohistochemistry revealed structural abnormalities characterized by myofiber disruption in HDAC3 KD hearts. Cardiac‐specific HDAC3 KD showed increased levels of whole‐body triglycerides and increased fibrosis. The introduction of deacetylase‐dead HDAC3 mutant in HDAC3 KD background showed comparable results with wild‐type HDAC3 in aspects of contractility and Pericardin deposition. However, deacetylase‐dead HDAC3 mutants failed to improve triglyceride accumulation. Our data indicate that HDAC3 plays a deacetylase‐independent role in maintaining cardiac contractility and preventing Pericardin deposition as well as a deacetylase‐dependent role to maintain triglyceride homeostasis.
Dental implant prognostication: A commentary
Authors: Kwok Vivien , Caton Jack G. , Hart Iain D. , Kim Ti‐Sun 
Published: February 2023

AbstractIn this commentary, a practical system for estimating the prognosis for dental implants is presented. Evidence for factors influencing implant prognosis is reviewed. The system is based on the stability of implant supporting tissues as opposed to implant loss.
Follow Your Nose
Authors: Miller Kristen A. , Sagaser Katelynn G. , Hertenstein Christine B. , Blakemore Karin J. , Forster Katherine R. , Lawson Cathleen S. , Jelin Angie C. 
Published: February 2023

ObjectiveExamine whether repeat nasal bone evaluation following an absent/uncertain nasal bone on first‐trimester screening (FTS) improves Down syndrome (DS) screening specificity.MethodsA retrospective chart review of FTS sonograms in one center from January 2015 to January 2018 was performed. Data was extracted for those with an absent/uncertain nasal bone. Repeat evaluations were offered.ResultsOf 6780 FTS sonograms, 589 (8.7%) had an absent/uncertain nasal bone. Upon repeat exam, 268/376 (71.3%) had a present nasal bone. Compared with Black patients, patients of other ethnicities were more likely to have a present nasal bone on exam 2 (P < .00001). Of 268 patients with a present nasal bone on exam 2, 37 (13.8%) had an abnormal DS risk following exam 1; 34/37 (91.9%) normalized following nasal bone visualization, dropping the screen positive rate to 1.1%.ConclusionRepeat nasal bone examination is beneficial in refining DS risk assessment and improves the specificity of FTS.
The Effect of Metformin on Vestibular Schwannoma Growth: A Systematic Review and Meta‐analysis
Authors: Lovin Benjamin D. , Wilkinson Alex J. , Qing Yun , Hernandez Mike , Nader Marc‐Elie , Raza Shaan , DeMonte Franco , Gidley Paul W. 
Published: February 2023

ObjectivesTo systematically review and evaluate metformin's potential impact on vestibular schwannoma (VS) growth.Data SourcesPubMed, Cochrane Library, and Embase.Review MethodsA retrospective cohort study was performed on sporadic VS patients undergoing initial observation who had at least two magnetic resonance imaging studies. Patients were stratified by metformin use during the observation period. Primary endpoint was VS growth, defined as at least a 2 mm increase in diameter. Survival free of tumor growth was evaluated between groups. Systematic review and meta‐analysis were performed to produce a pooled odds ratio [OR]. Study heterogeneity was assessed and post‐hoc power analysis was performed.ResultsA total of 123 patients were included, of which 17% were taking metformin. Median patient age was 56.6 years (range, 25.1–84.5). There were no statistically significant differences between the groups. Survival analysis did not demonstrate a statistically significant difference in time to VS growth between groups (hazard ratio = 0.61, 95% confidence interval [CI] = 0.29–1.29). Furthermore, logistic regression analysis did not demonstrate a statistically significant difference between groups in the odds of VS growth (OR = 0.46, 95% CI = 0.17–1.27). Systematic review identified 3 studies. Meta‐analysis suggested that metformin reduces the odds of developing VS growth (pooled OR = 0.45, 95% CI = 0.29–0.71). Studies demonstrated low between‐study heterogeneity. Power analysis demonstrated a sample size of 220 patients with equal randomization would be required to prospectively identify a true difference with 80% power.ConclusionsMetformin use may reduce the odds of VS growth. A randomized trial would be ideal to identify an unbiased estimate of metformin's effect on VS growth. Laryngoscope, 133:2066–2072, 2023
Aquatic carbon fluxes in a hemiboreal catchment are predictable from landscape morphology, temperature, and runoff
Authors: Balathandayuthabani Sivakiruthika , Wallin Marcus B. , Klemedtsson Leif , Crill Patrick , Bastviken David 
Published: February 2023

AbstractAquatic networks contribute greenhouse gases and lateral carbon (C) export from catchments. The magnitudes of these fluxes exceed the global land C sink but are uncertain. Resolving this uncertainty is important for understanding climate feedbacks. We quantified vertical methane (CH4) and carbon dioxide (CO2) emissions from lakes and streams, and lateral export of dissolved inorganic and organic carbon from a hemiboreal catchment for 3 yr. Lateral C fluxes dominated the total aquatic C flux. All aquatic C fluxes were disproportionately contributed from spatially restricted areas and/or short‐term events. Hence, consideration of local and episodic variability is vital. Temperature and runoff were the main temporal drivers for lake and stream C emissions, respectively. Whole‐catchment aquatic C emissions scaled linearly with these drivers within timeframes of stable land‐cover. Hence, temperature and runoff increase across Northern Hemisphere humid areas from climate change may yield proportional increases in aquatic C fluxes.
Organic Single Crystal with High Mobility, Ultrahigh UV Sensitivity, and Fast Time Response
Authors: Tao Jingwei , Sun Wenbo , Liu Dan , Tian Geng , Dong Huanli , Lu Lehui 
Published: February 2023

AbstractOrganic semiconductor molecule is a highly promising material system for next‐generation photodetectors due to its tunable absorption, inherent flexibility, and solution and low‐temperature processibility. However, developing organic semiconductor materials for visible‐blind ultraviolet (UV) photodetectors with broad spectral response remains a big challenge. Herein, a novel triphenylamine‐functionalized donor–acceptor–donor (D–A–D) type isoindigo derivative, (E)‐6,6'‐bis(4‐(diphenylamino)phenyl)‐[3,3'‐biindolinylidene]‐2,2′‐dione (BDPBD), is successfully synthesized. The ultrasensitive visible‐blind UV single crystal organic phototransistors (SC‐OPTs) based on the BDPBD micro/nanometer‐sized single crystal using simple solution process for the detection of ultraviolet‐A (UV‐A), ultraviolet‐B (UV‐B), and ultraviolet‐C (UV‐C) UV light showed a highest hole mobility of 0.12 cm2 V−1 s−1, millisecond‐level response time (20 ms), and ultrahigh photoresponsivity, detectivity, and external quantum efficiency up to 2.62 × 106 A W−1, 1.47 × 1017 Jones, and 3.51 × 108%, respectively.
Optical coherence tomography‐guided Nd:YAG laser treatment and follow‐up of basal cell carcinoma
Authors: Kranz Stefanie , Brunnmeier Gisela , Yilmaz Pelinsu , Thamm Janis , Schiele Stefan , Müller Gernot , Key Clara , Welzel Julia , Schuh Sandra 
Published: February 2023

AbstractObjectivesBasal cell carcinoma (BCC) is the most common skin tumor with an annually increasing incidence. Standard care requires several visits for diagnosis and treatment. Optical coherence tomography (OCT) as a diagnostic tool increases the sensitivity (95%) and specificity (77%) of the diagnosis of BCC. Although laser therapy is not the standard of care, the long‐pulsed 1064 nm Nd:YAG laser seems to be a promising option. However, data are scarce. The published papers had a short follow‐up (FU) time and used to some extent inferior methods to detect complete tumor clearance. To address this research gap, this study evaluates the efficiency of laser treatment by FU OCT. We pursue a patient‐focused approach and combine OCT with Nd:YAG laser treatment in one procedure.Materials and MethodsThe study was conducted as a prospective, single‐center trial that recruited biopsy‐confirmed or OCT‐proven BCC with a tumor thickness of less than 1.2 mm. Patients underwent two or three repeated sessions with the Nd:YAG laser (5–6 mm spot, fluence of 120–140 J/cm2, pulse duration of 8–10 milliseconds). Each BCC was assessed at baseline, and 3 and 12 months after laser treatment by clinical image, dermoscopy, and OCT. Incomplete tumor clearance (ITC) was defined as a clearly detectable BCC on the OCT image or a biopsy‐confirmed BCC in the treated area.ResultsForty‐five patients completed the 12‐month FU (46.7% women; median age of 74.0 [52–88] years) with a total number of 78 BCC lesions. At baseline, all patients had their BCC diagnosed by OCT (tumor thickness of 0.6 [0.4; 0.8] mm), 15.4% lesions were additionally diagnosed by histopathology. The most common subtype of BCC was superficial (48.7%), followed by nodular (47.4%) and infiltrative (3.8%). ITC rate after the treatment using Nd:YAG laser was 30.8% (95% CI: 20.8%–42.2%) (24/78) after 3 months and 7.4% (95% CI: 2.1%–17.9%) (4/54) after 12 months. ITC was not associated with histological subtype, tumor thickness, or location. If ITC was detected, the lesion was treated again. Out of 19 lesions with at least one additional laser treatment, 7 lesions (36.8%) suffered from incomplete tumor removal. In 46.7% of the treated lesions, the cosmetic outcome was rated as moderate or severe scarring after 12 months.ConclusionOur results demonstrate that the ITC rate of BCC treated with the Nd:YAG laser is much higher (up to one‐third) than reported, although the laser settings were identical to prior studies. This is especially evident at the 3‐month FU. In addition, we witnessed a larger number of side effects and a worse cosmetic outcome compared to previous studies.
Stability of stationary solutions to the Navier–Stokes equations in the Besov space
Authors: Kozono Hideo , Shimizu Senjo 
Published: February 2023

AbstractWe consider the stability of the stationary solution w of the Navier–Stokes equations in the whole space for . It is clarified that if w is small in for and , then for every small initial disturbance with and (), there exists a unique solution of the nonstationary Navier–Stokes equations on (0, ∞) with such that and as , for , , and small .
A single‐layer differential‐fed dual‐band filtering antenna for WLAN application
Authors: Huang Hao‐Yang , Hu Kun‐Zhi , Deng Jie , Yan Dong , Xie Jinfeng , Zhang Yan 
Published: February 2023

AbstractIn this letter, a single‐layer differential‐fed dual‐band filtering antenna for wireless local area network application is proposed. The proposed antenna consists of a square patch, and two pairs of stepped impedance resonators (SIRs). The lower operating passband is realized by exciting the square patch with a pair of differential ports. Then, a pair of SIRs is connected with the radiating edge of the square patch to introduce another resonance, thus forming the upper passband. And a radiation null is simultaneously produced to enhance the frequency selectivity between the two passbands. Moreover, another pair of SIRs is utilized to connect with the nonradiating edge of the square patch, which generates an additional high‐frequency in‐band resonance and a radiation null to further improve the bandwidth and frequency selectivity of upper passband. The developed prototype was fabricated and measured to verify the design concept. The measured results are in good agreement with the simulated ones, demonstrating that it exhibits −10 dB fractional impedance bandwidths of 3.68% and 7.35%, maximum realized gains at boresight direction of 5.5 and 8.7 dBi, and cross‐polarization levels smaller than −30 dB, in lower and upper passbands, respectively.
Novel low‐profile stacked edge grounded rectangular dielectric resonator antenna with compact size for UWB applications
Authors: Gaonkar Abhijeet , M. Ayyappan , Patel Pragati 
Published: February 2023

AbstractIn this paper, a low‐profile stacked dielectric resonator antenna (DRA) is proposed for ultra‐wideband applications. To improve the performance of the proposed antenna, techniques such as stacking of two dielectric materials, air gap slots, edge grounding technique, and the partial ground plane is employed. The measured impedance BW of the proposed antenna is 106% at the center frequency of 7.7 GHz (3.65–11.8 GHz). The analysis of field lines shows that the fundamental TEx111 mode is preserved at the first resonant frequency of 4.4 GHz. The maximum gain achieved over the operating frequency range is 6.38 dBi. The design is compact in its nature with a miniaturization capability of 66% of its volume. The proposed design is structurally simple, has a low weight, and has a high radiation efficiency of more than 90% in the operational range.
Deep learning‐based automatic pipeline for quantitative assessment of thigh muscle morphology and fatty infiltration
Authors: Gaj Sibaji , Eck Brendan L. , Xie Dongxing , Lartey Richard , Lo Charlotte , Zaylor William , Yang Mingrui , Nakamura Kunio , Winalski Carl S. , Spindler Kurt P. , Li Xiaojuan 
Published: February 2023

PurposeFast and accurate thigh muscle segmentation from MRI is important for quantitative assessment of thigh muscle morphology and composition. A novel deep learning (DL) based thigh muscle and surrounding tissues segmentation model was developed for fully automatic and reproducible cross‐sectional area (CSA) and fat fraction (FF) quantification and tested in patients at 10 years after anterior cruciate ligament reconstructions.MethodsA DL model combining UNet and DenseNet was trained and tested using manually segmented thighs from 16 patients (32 legs). Segmentation accuracy was evaluated using Dice similarity coefficients (DSC) and average symmetric surface distance (ASSD). A UNet model was trained for comparison. These segmentations were used to obtain CSA and FF quantification. Reproducibility of CSA and FF quantification was tested with scan and rescan of six healthy subjects.ResultsThe proposed UNet and DenseNet had high agreement with manual segmentation (DSC >0.97, ASSD < 0.24) and improved performance compared with UNet. For hamstrings of the operated knee, the automated pipeline had largest absolute difference of 6.01% for CSA and 0.47% for FF as compared to manual segmentation. In reproducibility analysis, the average difference (absolute) in CSA quantification between scan and rescan was better for the automatic method as compared with manual segmentation (2.27% vs. 3.34%), whereas the average difference (absolute) in FF quantification were similar.ConclusionsThe proposed method exhibits excellent accuracy and reproducibility in CSA and FF quantification compared with manual segmentation and can be used in large‐scale patient studies.
Effectiveness of Venting and Recompression for Increasing Postrelease Survival of Barotraumatized Black Sea Bass across a Range of Depths
Authors: Rudershausen Paul J. , Schmidt Hailey M. , Merrell Jeffery H. , Runde Brendan J. , Buckel Jeffrey A. 
Published: February 2023

Abstract
The effectiveness of venting and recompression for increasing postrelease survival for fish that experience barotrauma has rarely been tested across a range of depths. We conducted a field tag–recapture experiment to test how well venting and recompression each increased postrelease survival of Black Sea Bass Centropristis striata relative to untreated controls at three different depth ranges on the U.S. South Atlantic continental shelf: 24–26, 29–32, and 35–38 m. Venting and recompression were applied by researchers alongside untreated controls at all three depths, and venting by anglers who were inexperienced with this technique was an additional treatment at the intermediate depth. Tests of independence were used to evaluate the association between treatment type (venting versus controls) and postrelease submergence at each depth. Cox proportional hazards models were fit to the tag–recapture data that were collected at each depth to determine whether the experimental treatment influenced postrelease survival. Postrelease submergence was significantly higher in vented fish at the intermediate and deep depths but not at the shallow depth. The hazards rates were not significant for venting and recompression at the shallow and intermediate depths but were at the deepest depth, demonstrating that these techniques practiced at &gt;35 m increased postrelease survival relative to untreated controls. Mean increases in absolute survival at the 35–38 m depth were calculated to be 6.8% and 8.1% relative to controls when using venting and recompression, respectively. The results further suggest that anglers who are unfamiliar with venting do not reduce postrelease survival compared with venting by experienced personnel. These results provide guidance to fishery managers who are tasked with seeking methods to reduce catch-and-release mortality for an important reef species. Taken together, the findings from submergence success and survival models suggest that both venting and recompression should be encouraged to increase the postrelease survival of Black Sea Bass that are caught from depths &gt;29 m.
Combination of multiple active sites in N, O co‐doped defective carbon materials for high performance aqueous supercapacitors
Authors: Dong Yue , Dong Xiao , Zhu Dezhao , Yang Yanxiang , Luo Chen , Li Yang , Li Jinshan 
Published: February 2023

AbstractSupercapacitors have been used in a broad range of fields including electronics, transportation, and energies. Electrode materials with high capacitance and good rate performance are crucial for the future development and application of supercapacitors. Herein, we prepared N, O co‐doped defective carbon blocks (NO‐DCBs) with abundant active sites through carbonization and ball‐milling of polyimide. The as‐obtained NO‐DCBs exhibit high atomic content of N and O inherited from polyamic acid (PAA) precursor, as well as large amounts of intrinsic defects introduced by ball‐milling. Benefiting from the synergy of pseudocapacitance and electrical double‐layer capacitance provided by heteroatoms and intrinsic defects respectively, the NO‐DCBs assembled symmetric aqueous capacitor shows high capacitance of 329 F g−1 at 0.1 A g−1, good rate performance of 48% capacitance retention at 50 A g−1, and superb cycling stability. This work promotes the deep understanding of the synergy effect of functional groups and intrinsic defects for capacitive energy storage, and broadens the avenue for structural design of active sites in carbon materials.
Association of Pain Disorder and Psychiatric Disease With Surgical Management of Obstructive Sleep Apnea
Authors: Block‐Wheeler Nikolas R. , Darbinian Jeanne , Ansari Ghedak , Durr Megan 
Published: February 2023

AbstractObjectivePatients undergoing surgical management for obstructive sleep apnea (OSA) are likely medically distinct from their counterparts not treated surgically. This study examined the associations between psychiatric and pain comorbidities and the likelihood of undergoing sleep surgery.Study DesignA retrospective cohort study of adults with OSA.SettingLarge integrated health care system.MethodsThe primary outcome was nonnasal, nonbariatric sleep surgery. The associations of baseline demographic and comorbid conditions with surgery to treat underlying OSA were examined using bivariable and multivariable analyses.ResultsAmong 172,854 adults with OSA, 2456 received sleep surgery. Comorbid pain disorder and/or pain medication treatment was associated with 41% higher odds of surgery (95% confidence interval: 1.29‐1.54). In bivariable analyses, those with a history of headache (p = .004), particularly migraine (p = .003), disorders of adult personality or behavior (p = .025), or behavioral/emotional disorder (p < .001) were more likely to undergo surgery. Younger adults were also more likely to undergo surgery (mean age at diagnosis 39.8 ± 12.6 vs 54.7 ± 14 years), as were men, Asian/Pacific Islander or Hispanic adults, those with lower body mass index (32 ± 7 vs 34.3 ± 8.1 kg/m2), or those with Charlson Comorbidity Index of zero (p < .001).ConclusionOur study suggests a history of pain disorder (including receipt of pain medication), migraine, or certain behavioral and personality disorders are associated with an increased likelihood of undergoing sleep surgery. The findings may better characterize comorbid predictors of sleep surgery and potentially help clinicians tailor expectations, postoperative pain management, and overall sleep outcomes.
Postmarketing Reporting of Paxlovid‐Related Dysgeusia: A Real‐World Pharmacovigilance Study
Authors: Cvancara David J. , Baertsch Hans C. , Lehmann Ashton E. , Humphreys Ian M. , Farrell Nyssa Fox , Marshall Thomas B. , Bhatt Neel K. , Abuzeid Waleed M. , Jafari Aria 
Published: February 2023

AbstractObjectiveA novel COVID‐19 therapeutic, nirmatrelvir/ritonavir (Paxlovid), is commonly associated with reports of dysgeusia. The Food and Drug Administration Adverse Event Reporting System (FAERS) database was used to determine the real‐world reporting of Paxlovid‐associated dysgeusia (PAD), identify associated factors, and describe the relative reporting rates of dysgeusia for Paxlovid compared to other COVID‐19 therapeutics (OCT), ritonavir alone, and other protease inhibitors (OPI).Study DesignObservational retrospective.SettingTertiary academic medical center.MethodsWe collected patient and adverse event characteristics reported in the FAERS database between January 1968 and September 2022. Disproportionality analyses were used to compare the reporting of PAD to dysgeusia reported for OCT, ritonavir, and OPI.Results345,229 adverse events were included in the present study. Dysgeusia was a frequently reported Paxlovid‐associated adverse event (17.5%) and was associated with nonserious COVID‐19 infection (reporting odds ratio [ROR] 1.4; 95% confidence interval [CI] 1.2, 1.7) and female sex (ROR = 1.7; 95% CI 1.6, 1.9). Paxlovid was more likely to be associated with the reporting of dysgeusia compared to OCT (ROR 305.4; 95% CI 164.1, 568.5), ritonavir (ROR 28.0; 95% CI 24.1, 32.7), and OPI (ROR 49.0; 95% CI 42.8, 56.1).ConclusionDysgeusia is much more likely to be reported by patients receiving Paxlovid than those receiving OCT, ritonavir alone, or OPI. These findings suggest a potential mechanism of dysgeusia that causes distorted taste out of proportion to the background effects of COVID‐19 infection and specific to nirmatrelvir. Future studies are needed to determine the underlying pathophysiology and long‐term clinical implications for patients who report dysgeusia with Paxlovid.