bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agronomic feasibility of wheat and triticale cultivars in the semiarid of Minas Gerais State, Brazil
Authors: Santos Adson , Albuquerque Carlos , Sousa Franklin , Siqueira Raphael , Rocha Fernando , Custodio Adriano 
Published: February 2023

The production of winter cereals is becoming increasingly important in Brazil, largely due to advanced techniques that enable considerable qualitative and quantitative gains. This is due to plant breeding under different soil and climate conditions combined with proper management. The present study aims to assess the agronomic feasibility of growing wheat and triticale cultivars with two sowing times in the semiarid region of northern Minas Gerais State, Brazil. The experiment was conducted in 2018 at the Instituto de Ciências Agrárias (Institute of Agricultural Sciences) of Universidade Federal de Minas Gerais, Montes Claros campus. A randomized block design was used, with four replications and an 8 × 2 factorial arrangement consisting of eight genotypes (six wheat and two triticale cultivars) and two sowing times (April 21 and May 12, 2018). The irrigated production of wheat and triticale was agronomically feasible in the semi-arid region of Minas Gerais state and sowing time affected the main agronomic traits of interest of winter cereals. However, it is essential to study the economic feasibility of the crop. Sowing in April was the most indicated for wheat and triticale, with IPR Potyporã, IPR 144 and IPR 111 as the recommended cultivars.
The Relationship Between Testosterone Therapy and Rotator Cuff Tears, Repairs, and Revision Repairs
Authors: Testa Edward J. , Albright J. Alex , Hartnett Davis , Lemme Nicholas J. , Daniels Alan H. , Owens Brett D. , Arcand Michel 
Published: February 2023

Introduction:
The purpose of this study was to evaluate rates of rotator cuff tears (RCTs), repairs (RCRs), and revision RCR in patients who were prescribed testosterone replacement therapy (TRT) and compare these patients with a control group.

Methods:
The PearlDiver database was queried for patients who were prescribed testosterone for at least 90 days between 2011 and 2018 to evaluate the incidence of RCTs in this population. A second analysis evaluated patients who sustained RCTs using International Classification of Diseases, 9th/10th codes to evaluate these patients for rates of RCR and revision RCR. Chi square analysis and multivariate regression analyses were used to compare rates of RCTs, RCR, and subsequent or revision RCR between the testosterone and control groups, with a P-value of 0.05 representing statistical significance.

Results:
A total of 673,862 patients with RCT were included for analysis, and 9,168 of these patients were prescribed testosterone for at least 90 days before their RCT. The TRT group had a 3.6 times greater risk of sustaining an RCT (1.14% versus 0.19%; adjusted odds ratio (OR) 3.57; 95% confidence interval (CI) 3.57 to 3.96). A 1.6 times greater rate of RCR was observed in the TRT cohort (TRT, 46.4% RCR rate and control, 34.0% RCR rate; adjusted OR 1.60; 95% CI 1.54 to 1.67). The TRT cohort had a 26.7 times greater risk of undergoing a subsequent RCR, irrespective of laterality, within 1 year of undergoing a primary RCR when compared with the control group (TRT, 47.1% and control, 4.0%; adjusted OR 26.4; 95% CI 25.0 to 27.9, P < 0.001).

Conclusions:
There is increased risk of RCTs, RCRs, and subsequent RCRs in patients prescribed testosterone. This finding may represent a musculoskeletal consequence of TRT and is important for patients and clinicians to understand. Additional research into the science of tendon injury in the setting of exogenous anabolic steroids remains of interest.

Level of evidence:
Level Ⅲ, retrospective cohort study.
Larger Perioperative Opioid Prescriptions Lead to Prolonged Opioid Use After Hand and Upper Extremity Surgery: A Multicenter Analysis
Authors: Townsend Clay B. , Ly Justin A. , Judy Ryan , Sherman Matthew B. , Elmer Nick , Conroy Christine , Abdelfattah Hesham M. , Solarz Mark K. , Woozley Katharine , Ilyas Asif M. 
Published: February 2023

Introduction:
The opioid epidemic remains an ongoing public health crisis. The purpose of this study was to investigate whether surgeons' prescribing patterns of the initial postoperative opioid prescription predispose patients to prolonged opioid use after upper extremity surgery.

Methods:
This multicenter retrospective study was done at three academic institutions. Patients who underwent carpal tunnel release, basal joint arthroplasty, and distal radius fracture open reduction and internal fixation over a 1.5-year period were included. Opioid prescription data were obtained from the Pennsylvania Prescription Drug Monitoring Program website.

Results:
Postoperatively, 30.1% of the patients (191/634) filled ≥1 additional opioid prescription, and 14.0% (89/634) experienced prolonged opioid use 3 to 6 months postoperatively. Patients who filled an additional prescription postoperatively were initially prescribed significantly more pills (P = 0.001), a significantly longer duration prescription (P = 0.009), and a significantly larger prescription in total milligram morphine equivalents (P = 0.002) than patients who did not fill additional prescriptions. Patients who had prolonged opioid use were prescribed a significantly longer duration prescription (P = 0.026) than those without prolonged use.

Conclusion:
Larger and longer duration of initial opioid prescriptions predisposed patients to continued postoperative opioid use. These findings emphasize the importance of safe and evidence-based prescribing practices to prevent the detrimental effects of opioid use after orthopaedic surgery.
Usage of a Value-based Triaging Methodology for Assessing Improvements in Value for Hip Fracture Inpatient Episodes of Care From 2014 to 2019: A Pilot Study
Authors: Konda Sanjit R. , Ranson Rachel , Denasty Adwin , Egol Kenneth A. 
Published: February 2023

Introduction:
The purpose of this study was to demonstrate a novel technology used to measure improvements in quality and value of care for treatment of hip fracture patients.

Methods:
A novel value-based triaging methodology uses a risk prediction (risk M) and inpatient cost prediction (risk C) algorithm and has been demonstrated to accurately predict high-risk:high-cost episodes of care. Two hundred twenty-nine hip fracture patients from 2014 to 2016 were used to establish baseline length of stay (LOS) and total inpatient cost for each (16) risk:cost quadrants. Two hundred sixty-five patients between 2017 and 2019 with hip fractures were input into the algorithm, and historical LOS and cost for each patient were calculated. Historical values were compared with actual values to determine whether the value of the inpatient episode of care differed from the 2014 to 16 cohort.

Results:
When evaluated without risk or cost stratification, the mean actual LOS and cost of the baseline cohort compared with the 2017 to 2019 cohort were 8.0 vs 7.5 days (P = 0.43) and $25,446 vs $29,849 (P = 0.15), respectively. This analysis demonstrates that there was only a small change in value of care provided to patients based on LOS/cost over the studied period; however, risk:cost analysis using the novel methodology demonstrated that for select risk:cost quadrants, value of care measured by LOS/cost improved, whereas for others it decreased and for others there was no change.

Conclusion:
Risk-cost–adjusted analysis of inpatient episodes of care rendered by a value-based triaging methodology provides a robust method of assessing improvements and/or decreases in value-based care when compared with a historical cohort. This methodology provides the tools to both track hospital interventions designed to improve quality and decrease cost as well as determine whether these interventions are effective in improving value.
The Impact of Sex on the Outcomes of Prosthetic Joint Infection Treatment with Debridement, Antibiotics and Implant Retention: A Systematic Review and Individual Patient Data Meta-analysis
Authors: Choong Annabelle L. , Shadbolt Cade , Choong Emma , Spelman Tim , Muñoz-Mahamud Ernesto , Lora-Tamayo Jaime , Kim Katy , Wouthuyzen-Bakker Marjan , Spangehl Mark , Chayakulkeeree Methee , Young Simon W. , Choong Peter F. M. , Dowsey Michelle M. 
Published: February 2023

Background:
The influence of sex on the failure of débridement antibiotics and implant retention (DAIR) for treating prosthetic joint infection (PJI) is important for decision-making, patient counseling, and equitable health care. However, very few studies in the orthopaedic literature conduct sex-specific analyses.

Aim:
The primary aim was to determine whether sex influences treatment success after DAIR.

Methods:
A systematic review and individual patient data (IPD) meta-analysis was conducted. MEDLINE (Ovid), EMBASE (Ovid), Web of Science, and Google Scholar were searched, and IPD was requested via e-mail. Patients who underwent DAIR after developing PJI within 12 months of a primary total hip or knee arthroplasty were included in the analysis. Treatment failure was defined by the Delphi International Consensus criteria. Adjusted odds ratios for treatment failure were calculated using a mixed-effects logistic regression.

Results:
The study collected and analyzed IPD of 1,116 patients from 21 cohorts. The odds of treatment failure were 29% lower in women (odds ratio, 0.71; 95% CI 0.54 to 0.017; P = 0.017), after adjusting for duration of symptoms >7 days and Staphylococcus aureus infection (methicillin-susceptible Staphylococcus aureus or any infection with S aureus). None of the 64 studies included in the systematic review conducted a sex-specific analysis.

Conclusion:
For patients who developed a PJI within 1 year postsurgery, females have lower odds of DAIR failure than males. Other factors also have varying effects on outcome for men and women. It is essential to implement sex-specific analysis in orthopaedic research.
Systematic Review of Ligament Reconstruction of Traumatic Isolated Thumb Carpometacarpal Joint Dislocation
Authors: Court Tannor , Hussain Kumail , Kim Jennifer Sohjeong , Patel Ishan , Higginbotham Devan O. , Tsai Andrew G. 
Published: February 2023

Introduction:
Thumb carpometacarpal (CMC) joint dislocations are rare with minimal agreement on surgical management. The dorsoradial ligament (DRL) is the primary joint stabilizer but has not historically been reconstructed. We hypothesize that the reported reconstruction of first CMC joint dislocations primarily uses the flexor carpi radialis (FCR) without collective agreement on a surgical technique.

Methods:
A systematic review of the PubMed database from 1996 to 2022 was done. Keywords were “thumb dislocation,” “thumb carpometacarpal dislocation,” and “carpometacarpal joint ligament repair.” Inclusion criteria included isolated, unstable thumb CMC dislocations with reconstruction. The Preferred Reporting Items for Systematic Reviews and Meta Analyses guidelines were used.

Results:
Four hundred thirty-seven records were identified, and nine met inclusion criteria. Two articles were cohort studies, and seven were case reports. Thirty-seven patients were included, and 26 patients had reconstruction with tendonous autograft. Twenty-five (96.2%) used the FCR and 1 (3.9%) from the palmaris longus. Three patients had reconstruction with a suture anchor. Surgical techniques varied between studies.

Discussion:
The recommendation of the authors recreates the DRL during autograft repair. Current repair techniques that recreate the DRL use the FCR, but quantitative comparisons of tendonous autografts or suture anchors have not been done.
Orthopaedic Surgical Demand Index: A Measure of Need in the United States
Authors: Davison-Kerwood Maxwell , Jiang Sam , Gonzalez1 Mark 
Published: February 2023

Background:
Before being evaluated by a physician, more than 50% of patients will search their symptoms on the Google search engine. In fact, Google was the engine used for nearly 90% of all online searches between 2016 and 2018. These search data are stored by Google and can be investigated through google extended trends for health (GETH). The goal of this research was to use GETH to correlate Google search probabilities for elective orthopaedic procedures with the orthopaedic surgeon density in each US state to create a surgical demand index (SDI) that could be then compared between states. In addition, this study aims to assess the effects of annual income, percent minority population, and unemployment rate on that SDI.

Methods:
Google search probabilities were collected using the Google Trends Extraction Tool. Search probabilities were collected in each state for composite search terms. Data were collected in monthly intervals between 2016 and 2018 and averaged. The states were grouped into geographic regions. One-way analysis of variance and pairwise Mann-Whitney U tests were done between these regions. Linear regression analysis was conducted to assess the effect of median annual statewide income, percent minority population, and unemployment rate with SDI.

Results:
The analysis of variance and Mann-Whitney U tests demonstrated a difference between regions. Linear regression analysis revealed a notable effect of median income on SDI, but no effect of percent minority population or unemployment rate.

Conclusions:
The Midwest and South had higher regional demand than the Northeast and West, with West Virginia being the most in need and the District of Columbia being the least in need. Annual median income had a notable negative effect on SDI, whereas percent minority population and unemployment rate had no effect. This study highlights the inequality that exists in the southern and midwestern United States and identifies one potential predictive factor of this unequal SDI.
Comparing Venous Thromboembolism Prophylactic Agents After Hip Fracture Surgery: A National Database Study
Authors: Joo Peter Y. , Modrak Maxwell , Park Nancy , Brand Jordan , Rubin Lee E. , Grauer Jonathan N. , Bernstein Jenna A. 
Published: February 2023

Introduction:
Although the use of venous thromboembolism (VTE) chemoprophylaxis has markedly reduced VTE rates after hip fracture surgery, few studies have directly compared the efficacy of different anticoagulant agents in this setting. The purpose of this study was to compare outcomes of Lovenox, Eliquis, or Coumadin as VTE prophylaxis after hip fracture surgery.

Methods:
The PearlDiver MHip national database was queried for patients older than 60 years undergoing first-time hip fracture surgery with no concurrent pelvic or distal femoral fractures. Prescriptions for Lovenox, Eliquis, or Coumadin were identified. Univariate and multivariate analyses of patient characteristics, 90-day incidences of VTE, adverse events, and readmissions were compared. Odds ratios (ORs) were calculated, and significance was set at P < 0.01 based on Bonferroni adjustment.

Results:
A total of 11,384 patients were identified, with the Lovenox used for 6835 patients (60.0%), Eliquis for 1092 patients (9.6%), and Coumadin for 3457 patients (30.4%). The prevalence of 90-day VTE in the Lovenox, Eliquis, and Coumadin groups was 3.1%, 3.8%, and 5.0%, respectively (P < 0.001). Multivariate analyses adjusting for demographic and comorbidity profiles were conducted with Lovenox as the referent. Those on Eliquis had significantly lower transfusions (OR 0.52, P = 0.005), but similar rates of other outcomes including VTE (P > 0.01). Conversely, patients on Coumadin had significantly greater odds of any adverse event (OR 1.18, P < 0.001) and VTE (OR 1.58, P < 0.001).

Discussion:
In evaluating Lovenox, Eliquis, and Coumadin as VTE chemoprophylactic agents after hip fracture surgery in anticoagulant-naïve patients, Lovenox and Eliquis had similar 90-day VTE, whereas patients on Coumadin had greater odds of 90-day VTE. Interestingly, patients on Eliquis had nearly two-fold lower odds of transfusions compared with patients on Lovenox. Although consensus on the optimal VTE prophylactic agent after hip fracture surgery does not exist, Eliquis and Lovenox may be comparable options and seem to be more effective than Coumadin.
Comparative study of Retrograde Intrarenal Surgery and Mini-Percutaneous Nephrolithotomy among Renal Stone Patients
Authors: Maqsood Zahid Muhammad , Farook Khalid , Ahmad Khaleel , Ali Liaquat , Muhammad Javed Hafiz , Mehmood Ul Hassan Syed 
Published: February 2023

Mini-Percutaneous Nephrolithotomy (Mini-PCNL) and Retrograde intra-renal surgery (RIRS), can be carried out in a single stage or numerous phases depending on the burden, size, and/or location of the stone. Objective: To check the efficacy of Mini-Percutaneous Nephrolithotomy and Retrograde intra-renal surgery on adult patients with a renal stones. Methods: A total of 101 patients were included who underwent RIRS (n=51) or mini-PCNL (n=50) at Doctors Hospital Jail Chowk in Gujrat, Pakistan in 2021. Retrospective observations were made on 101 individuals who received RIRS or mini-PCNL. Results: The mean hospital stay time was significantly lower in RIRS group i.e., 01.81 ± 0.59 days as compared to mini-PCNL group (p value <0.001). The operation time was 63.72 ± 14.94 minutes for mini-PCNL and 72.65 ± 15.83 minutes for RIRS group. The stone clearance rate was 92% in mini-PCNL group and 82.35% in RIRS group. Conclusions: In conclusion, we found that both mini-PCNL and RIRS are safe and effective ways to treat renal calculi. RIRS is a non-invasive, practical therapeutic option with reduced hospitalizations times, morbidity, and complication rates for these individuals.
Comparative influence of kolaviron and coenzyme Q10 on complex I activity, glutamate clearance, 3,4-dihydroxyphenethylamine metabolism, and redox stress in rotenone-induced neurotoxicity
Authors: Akinmoladun A. C. , Saliu Ibrahim , Abilogun Olaoluwa , Ajibola Omotola Helen , Amoo Zainab Abiola , Ojo Olubukola Benedicta , Farombi Ebenezer O. , Olaleye Mary Tolulope 
Published: February 2023

3,4-dihydroxyphenethylamine (dopamine) depletion, inhibition of complex I activity, oxidative stress, and glutamate excitotoxicity are cardinal biochemical features of neurotoxicity induced by systemic unilateral infusion of rotenone. Kolaviron (KV), a biflavonoid from Garcinia kola seeds, has been proven to have pharmacological effects against neurotoxicity. Coenzyme Q10 plays an essential role in mitochondrial oxidative phosphorylation and as an antioxidant. This study examined the comparative influence of kolaviron and coenzyme Q10 on complex I activity, dopamine metabolism, glutamate clearance, and redox stress in rotenone-induced neurotoxicity in the cortex, hippocampus, and striatum of the brain of rats. Adult Male Wistar rats were pretreated with 200 mg/kg KV or 100 mg/kg coenzyme Q10 for 7 days followed by administration of a progressive six doses of 1.5 mg/kg rotenone within the next 48 h after which the animals were euthanized and the brain excised. On the cortical, hippocampal, and striatal regions of the brain, complex I activity, dopamine metabolism, oxidative stress markers, as well as glutamate metabolism were carried out and analyzed. In all brain regions examined, KV and coenzyme Q10 pretreatment modulated complex I activity, ameliorated redox imbalance, and enhanced dopamine metabolism via increasing the activity of tyrosine hydroxylase and decreasing monoamine oxidase activity. KV facilitated glutamate clearance through augmentation of glutamate dehydrogenase and glutamine synthetase activities. The activity of KV was comparable to that of the mitochondrial membrane antioxidant compound, coenzyme Q10, this indicates that KV is a promising therapeutic agent in the treatment of Parkinson’s disease and its activity compares well with coenzyme Q10
PENGARUH STRATEGI PEMBELAJARAN HYPNO QUANTUM TEACHING TERHADAP MOTIVASI BELAJAR TARUNA POLTEKPEL SURABAYA
Authors: H Sri Mulyanto , Suparman Jaja , Rumambi C 
Published: February 2023

Peran dosen dalam membangkitkan motivasi belajar taruna sangat diperlukan danmenjadi kunci penting berhasilnya proses belajar mengajar di kelas. Oleh karena itudiperlukan strategi pembelajaran yang dapat menjadikan taruna lebih aktif, kreatif danmerangsang munculnya life skills, serta menciptakan suasana belajar yang menye­ nangkan (joyfull learning). Peneliti mempunyai ketertarikan untuk memadukan unsur hypnosis dan metode quantum teaching dalam proses pembelajaran sehingga menjadisuatu formula metode baru hypno quantum teaching. Bila dengan quantum teaching, proses belajar mengajar dapat berlangsung dengan menyenangkan ijoyfuli learning) maka dengan hypnosis diharapkan ada modifikasi perilaku sehingga terbentuk perilakubaru yang sesuai dengan harapan dosen.
Metode dalam penelitian ini menggunakan metode eksperimen yang didesain untukdapat mengendalikan secara ketat variabel-variabel ekstra yang tidak berhubungan dengan variabel yang sedang diamati. Adapun sampel dalam penelitian ini adalah tarunaPoltekpel Surabaya dengan menggunakan teknik analisis quota sampling dan teknik analisis data dengan menggunakan model aplikasi statistik SPSS versi 21. 0 yaitu dengananalisis paired samples Tnest. Hasil dari penelitian ini menunjukkan bahwa perlakuan dalam eksperimen dapatmeningkatkan kemampuan belajar subyek. Dengan meningkatnya kemampuan belajarsubyek mengindikasikan bahwa motivasi belajar subyek meningkat. Hipotesis diterimadengan didasarkan pada basil t = 2, 17 5 dengan signifikansi 0,045 yang berarti signifikan.Hasil ini menunjukkan bahwa ada pengaruh penggunaan metode hypno quantumteachingterhadap motivasi belajar mahasiswa. Penggunaan strategi pembelajaran hypnoquantum teaching cukup efektif dalam meningkatkan motivasi belajar, khususnyapenerapannya kepada taruna.
ANALISA PENERAPAN SISTEM MANAJEMEN KESELAMATAN DAN KESEHATAN KERJA DI POLITEKNIK PELAYARAN SURABAYA
Authors: Haryanto Dwi , Simanjuntak Marihot , Wiratno Daviq 
Published: February 2023

Sebagai salah satu institusi yang bergerak dibidang pelayanan jasa pendidikan dan pelatihan di bidang pelayaran Politeknik Pelayaran Surabaya (Poltekpel) Surabaya dalam menjalankan tugas pokok dan fungsinya selalu memperhatikan faktor keselamatan di lingkungan kerjanya. Sistern Manajemen Keselamatan dan Kesehatan Kerja (SMK3) merupakan suatu sistem pengaturan kebijakan-kebijakan institusi yang berfungsi sebagai pengontrol bagi pelaksanaan kebijakan K3 yang diterapkan oleh institusi. Lima prinsip penerapan SMK3 tersebut terns dilakukan perbaikan berkelanjutan oleh manajemen Poltekpel Surabaya. Perbaikan berkelanjutan dilakukan agar kesinarnbungan penerapan SMK3 dapat ditingkatkan sehingga mengurangi angka kecelakan kerja atau rnendapatkan zero accident. SMK3 yang diterapkan diberlakukan untuk semua karyawan, pegawai, instruktur, dosen dan peserta diklat secara terntegrasi antara mesin, manuasia, material dan lingkungan, sehingga mcnghasilkan penghargaan zero accident atau nol kecelakaan. Penilaian resiko bahaya kerja dengan HIRA, poteusi bahaya kerja yang teridentifikasi yaitu dengan kategori dominan high risk atau M menunjukkan bahwa program SMK3 dilingkungan kerja Politeknik Pelayaran Surabaya perlu diterapkan agar dapat mengantisipasi potensi bahaya yang akan terjadi dan zero accident lebih ditingkatkan