bluuebunny/crossref_metadata_2025_split huggingface dataset:
BENTHIC FORAMINIFERAL MORPHOGROUPS AND TRACE FOSSILS FROM ALBIAN SHALLOW-MARINE MUDSTONE FACIES OF THE VIKING FORMATION, WESTERN INTERIOR SEAWAY, CANADA
Authors: MCNEIL DAVID H. , MACEACHERN JAMES A. 
Published: June 2023

ABSTRACT
This study assesses the foraminiferal morphogroup concept as a quantitative tool for interpreting environments of deposition in the geological record. This was achieved by first establishing a solid paleoenvironmental framework based on assessment of trace fossils (Zoophycos, Cruziana, and Phycosiphon ichnofacies, and the unnamed brackish-water association), sedimentology, and facies analysis of shallow-marine siliciclastic units of the upper Albian Viking Formation of the Western Interior Seaway, Canada. Foraminiferal morphogroups were integrated into a framework of six well-defined marine mudstone-dominated facies—estuarine, embayment, prodelta, upper offshore, lower offshore, and marine shelf. Seven morphogroups were recognized, quantified, and labeled using alphanumeric codes—A (tubular), B1 (globular), B2 (coiled, flat), B3 (lenticular), C1 (elongate), C2 (quinqueloculine), and D (trochospiral).
Tubular forms (A, Bathysiphon) occur rarely in these shallow-marine facies. Globular forms (B1, Lagenammina) are common in estuarine (33%) and embayment (23%) facies, but also occur elsewhere in low numbers (7–14%). Coiled planar forms (B2, Ammodiscus) occur only rarely (1–8%), but have a minor presence in embayment facies (8%). Lenticular forms (B3, Haplophragmoides) are dominant in estuarine facies (43%) and occur commonly in other environments (9–29%) as well. Elongate forms (C1, Ammobaculites, Reophax, Verneuilinoides) dominate all shallow-marine facies (43–80%), except estuarine (10%). Quinqueloculine forms (C2, Miliammina) have a minor presence in prodelta and marine facies (5%) but are generally rare. Trochoid forms (D, Trochammina) occur rarely, but are relatively common in the prodeltaic facies (15%). Albian foraminiferal morphogroups of the Viking Formation are comparable to those of modern-day offshore environments from water depths of 13 to 160 meters. Foraminiferal morphogroups are objective entities independent of taxonomic determinations. Analysis of their form and function is applicable not only in the shallow-marine facies of the Albian Western Interior Seaway, but in similar facies throughout the geologic record.
Shade Selection for Natural Tooth Color Replication on Porcelain Laminate Veneers
Authors: Cunha Leonardo Fernandes da , Schelbauer Ricardo Susin , Costa Helton , Tabata Lucas Fernando , de Mello Daniella Birnbaum Pessoa , Kunz Patrícia Valeria Manozzo , Baratto Samantha Schaffer Pugsley , Baratto-Filho Flares , Madalena Isabela Ribeiro 
Published: June 2023

Abstract
Introduction: The final color of dental ceramics depends on different factors such as light source, substrate, and selected material (thickness, contour, and texture).
Objective: to report a clinical case in which a predictable protocol is used to optimize the final color of porcelain laminate veneers
Case report:: A male patient attended the dental clinic dissatisfied with the composite resin restorations made on his upper anterior teeth. After anamnesis and clinical examination, it was suggested that the resin restorations be replaced by laminated porcelain veneers. A diagnostic wax-up was performed. The mock-up was also used to evaluate the aesthetic length for replicating the details of the incisal edge and the shape and size of the embrasures. The shade was selected before composite resin removal to avoid dehydration of the dental substrate. A photograph was taken to guide the selection of colors in different thirds. After removing the restorations, another photograph was taken to evaluate the color of the substrate. The impression was taken with 000 retractor wire and addition silicone. The laminates were made with pressed ceramic and feldspathic porcelain veneers were subsequently applied by layering the layers of dentin, incisal edge and enamel based on the waxing diagnosis. After approval by the patient, a conventional cementation technique was performed. The occlusal adjustment was made with rubber polishing cups and the anterior and lateral guides were checked.
Conclusion: The protocol recommended for successful selection of the color of a porcelain laminate relies on the combination of knowledge of concepts, resources such as shade guides, spectrophotometers, and photographs, and porcelain application and characterization techniques performed by the technician and luting techniques by the dentist.
Perinatal outcomes of asthma exacerbation during pregnancy in a Chinese population: a retrospective cohort study
Authors: Wang Yan , Chang Chun , Li Tongxin , Dong Fawu , Li Nan 
Published: June 2023

Abstract
Asthma exacerbation (AE) is a significant clinical problem during pregnancy. This study aimed to identify factors and perinatal and offspring outcomes associated with AE during pregnancy. We conducted a retrospective cohort study using the Peking University Third Hospital database from January 1, 2013 to December 31, 2020. We compared the clinical characteristics and perinatal and offspring outcomes of asthma with and without exacerbations among women who delivered during this period. The prevalence of gestational asthma increased from 0.52% in 2013 to 0.98% in 2020. Of the 220 patients with gestational asthma included in the study, 105 experienced AE during pregnancy: 62.9% (n = 66) had mild-to-moderate AE and 37.1% (n = 39) had severe AE. Pregnant women with allergic rhinitis have a higher risk of AE during pregnancy. The mean fetal weight was lower in the AE group than in the non-AE group (p = 0.01). Women who experienced AE were more at risk for gestational hypertension and preeclampsia than women who did not experience any exacerbation.
Prenatal diagnosis identifies compound heterozygous variants in PKDCC that causes Rhizomelic Limb Shortening with Dysmorphic Features in a Chinese fetus
Authors: Yan Lulu , Cao Juan , Zhang Yuxin , Liu Yingwen , Zou Jinghui , Lou Biying , Zhuang Danyan , Li Haibo 
Published: June 2023

Abstract
Background: Rhizomelic limb shortening with dysmorphic features (RLSDF) has already been a disorder of the rare autosomal recessive skeletal dysplasia, just having a few reported cases. RLSDF is caused by PKDCC gene variants. In this article, the clinical features and potential RLSDF molecular etiology in a Chinese fetus are depicted.
Methods: Genomic DNA (gDNA) extracted from the fetal muscle tissue and parents’ peripheral blood was subjected to chromosomal microarray analysis (CMA) and trio-based whole exome sequencing (Trio-WES). The candidate pathogenic variants were verified by Sanger sequencing.
Results: Trio-WES identifed two compound heterozygous variants in PKDCC, c.346delC (p.Pro117Argfs*113) and c.994G>T (p.Glu332Ter), inherited from the father and mother, respectively. Both variants are classified as pathogenic according to ACMG guidelines.
Conclusions: It was reported the first prenatal case of PKDCC caused RLSDF among Chinese population. Our findings extended the variation spectrum of PKDCC and emphasized the necessity of WES for early diagnosis of fetuses with skeletal dysplasia and other ultrasound structural abnormalities.
Back analysis of shear strength parameters of failed slopes using probabilistic approach: two case studies
Authors: Nassirzadeh Reza , Dini Abdollah , Balagar Vahid 
Published: June 2023

Abstract
In general, geotechnical investigations deal with the back analysis of the geotechnical parameters on the basis of the field observation. According to the back analysis method introduced in the present study, geometry of a number of failed slopes have been carefully mapped and then statistical features of the groundwater level, the bulk unit weight and other measurable parameters have been determined. After that, a series of two-dimensional models for back analysis of the failures have been established. Moreover, statistical analyses based on probabilistic approaches have been utilized to estimate the variation ranges of the shear strength variables. The study provided the probabilistic back analysis of the slope failure with the two case studies in the copper mines of Anjerd and Daraloo. Results indicated that the approach to the probabilistic back analysis has been effective in the analysis of the slope failures wherein considerable uncertainty has been observed in the shear strength and other influential variables. Furthermore, the probabilistic back analysis presented a lot of information in comparison to the approach to the deterministic back analysis and thus had more reasonable matching with the practice of geotechnical engineering in the real world. Therefore, this method would be beneficial and practical for stability analysis, redesigning the slopes, designing the new slopes under the same geotechnical conditions and promote the construction safety. The probabilistic back analysis could be also used to estimate the shear parameters and analyze the stability of slopes as a cost-effective and high reliability method.
An evaluation of optometric advanced skills within a UK tertiary based setting
Authors: Jindal Anish , Abdulrasid Safwana , Mulholland Pádraig , Anand Vijay , Siriwardena Dilani 
Published: June 2023

Abstract
Introduction
Hospital-based optometrists are undertaking numerous extended roles across ophthalmology, Moorfields Eye Hospital (MEH) NHS Foundation Trust is the largest UK employer of hospital-based optometrists. It was sought to investigate what advanced skills (AS) are being performed and their relevance to the four pillars of advanced clinical practice (ACP) in this centre.
Methods
An online survey was sent to MEH optometrists in May 2022 that asked about professional status, subspecialties worked, qualifications, performance and validation of AS, research and leadership.
Results
Ninety-six responses were received, mean post-qualification experience was 16.2 (SD 10.4). There were 84 independent AS that covered clinical, leadership and research, with respondents achieving a mean of 11.8 (SD 10.3) AS. Those with independent prescribing (IP) qualifications (n = 52) had a higher number of AS compared to non-IP optometrists (p = 0.03). There were 68 clinical AS across the subspecialties (23 clinical AS were common in 2 or more subspecialties), 49 out of 120 clinical AS could be performed by at least 60% of staff. Twenty-six optometrists identified with leadership, fifty-six had undertaken research/audit, 27 had published within a peer-reviewed journal and 50% of time spent on research was supported by funding.
Conclusion
AS are being performed by optometrists within a tertiary eye hospital that supports ACP. IP Optometrists IP had higher self-reported AS but current educational frameworks don’t accommodate for some AS. Targeted AS courses with competency-based sign-off may further support high-quality patient care. Further research is required on how advanced care practitioners can be provisioned to support workforce transformation.
Spatial Model of Dengue Hemorrhagic Fever (DHF) Risk: Scoping Review
Authors: Pakaya Ririn , Daniel D. , Widayani Prima , Utarini Adi 
Published: June 2023

Abstract
This review aims to provide a comprehensive overview of the important predictors, and additionally spatial modeling tools capable of producing Dengue Hemorrhagic Fever (DHF) risk maps. A literature search was conducted in PubMed, Scopus, Science Direct, and Google Scholar for studies reporting DHF risk factors. The Preferred Reporting Items for Systematic Reviews (PRISMA) 2020 statement is used to report this scoping review. It lasted from January 2011 to August of 2022. Initially 1329 articles were found, after inclusion and exclusion criteria, 45 manuscripts were selected. A variety of models and techniques were used to identify DHF risk areas with an arrangement of various multiple-criteria decision-making, statistical, and Machine Learning technique. We found that There was no pattern of predictor use associated with particular approaches; instead, a wide range of predictors was used to create DHF risk maps. Predictors are various variables or factors that are considered when assessing the likelihood or intensity of DHF outbreaks in a specific area in the context of DHF risk mapping. These predictors can include climatology factors (e.g., temperature, rainfall, humidity), socio-economic indicators (e.g., population density, urbanization level), environmental factors (land-use, elevation) and other relevant factors (e.g., mosquito abundance, previous DHF cases). The spatial model of DHF risk is a valuable tool for public health authorities, policymakers, and communities to identify areas at higher risk of dengue transmission, but its limitations underscore the importance of complementing it with other approaches and considering contextual factors for a more holistic assessment of DHF outbreaks. It enables targeted interventions, such as vector control measures and public awareness campaigns, to be implemented in high-risk areas, ultimately helping to mitigate the impact of dengue outbreaks and protect public health.
Coupling of Evapotranspiration with Anthropogenic parameters -A case study of Central and Eastern India
Authors: Shweta  , Bhattacharya Bimal Kumar , Krishna Akhouri Pramod 
Published: June 2023

Abstract
Through present work district wise coupling of anthropogenic forcing’s with Evapotranspiration (ET) for the years 2001-2010 over Indian state of Bihar and Madhya Pradesh has been identified. Here, calibrated Moderate Resolution Imaging Spectroradiometer (MODIS) annual ET data i.e MOD 16 8-Days ET Product along with different statistics related to agricultural management factors such as Net sown area (NSA), Gross cultivated area (GCA), Agriculture sown area more than once (ASMO), Net irrigated area (NIA), Gross irrigated area (GIA) alogwith Ground water level data were used. And, to identify coupling of ET with selected parameters Mann Kendall trend test statistics and correlation analysis have been performed at district-level. Thus, result thus obtained showed a good coupling and coorelation of ET with selected anthropogenic factors and this noticed coupling factor were covering 46% area of the state Bihar and 50% area of Madhya Pradesh and Correlation coefficient of these parameters with ET were ranging up to 0.9 for both the study states.
*Corresponding Author:Shweta
Email:swetagpt29@gmail.com
Thus, this part of the analysis showed very explicitly that ET was very well coupled with anthropogenic factors which is a good indication in terms of agricultural production, and at the same time shows alarming situation for exploition of irrigation resources for the respective states.
Towards the development of a direct method for the detection of autologous blood transfusions in sport doping: targeting the red blood cells “storage lesions”
Authors: Biasini Giorgia M , Botre Francesco , Torre Xavier de la , Donati Francesco 
Published: June 2023

Abstract
Background and objective: Autologous blood transfusion is a form of “blood doping” banned by the World Anti-Doping Agency. At present, this practice is detectable exclusively by the individual, longitudinal monitoring of hematological biomarkers, as in the hematological module of the Athlete Biological Passport; but this indirect approach may suffer from different confounding factors. We are presenting a multi-parametric, analytical strategy to detect autologous blood transfusions by targeting the modification of the red blood cells during storage. We focused on the assessment of “storage lesions” that occur to red blood cells between the withdrawal and the re-infusion.
Methods: We specifically focused on (i) membrane proteins: Glycophorin-A and Band 3 complex, (ii) biomarkers of oxidative stress: Peroxiredoxin-2 (PRDX2), (iii) biomarkers of senescence: CD47 and Phosphatidylserine, (iv) erythrocytes microparticles. All of the above were monitored, by immunological and flow cytofluorimetric methods, on samples of stored whole blood collected at different time intervals, and on fresh and blood samples mixed “ex vivo” to simulate an autotransfusion.
Results: Our results showed that the irreversible alteration of RBCs morphology, the loss of membrane integrity, the occurrence of hemolysis phenomena, and, more in general, the “aging” of the erythrocytes during storage are closely related to the reduced concentration of Band 3 protein and glycophorin A in the erythrocyte membrane, to the externalization of phosphatidyl serine and to the reduced concentration of CD47. In parallel, increasing levels of erythrocyte microparticles are produced during storage.
Conclusions: The most promising method to detect the presence of transfused blood in whole blood samples can be based on a multi-parametric strategy, considering jointly both protein expression on RBCs membranes and micro-vesiculation phenomena.
Development of a Novel Indirubin Derivative with Enhanced Anticancer Properties: Synthesis, In Vitro, and In Vivo Evaluation
Authors: Nguyen Trong Dan , Le Thai Minh Duy 
Published: June 2023

Abstract
The indirubin (2) derivative undergoes condensation with hydroxylamine hydrochloride, resulting in the formation of a novel indirubin derivative (3) that incorporates both the oxime group and the piperidine heterocycle. This compound is subsequently treated with hydrochloric acid in ethanol, leading to the formation of the hydrochloride salt (4), which exhibits excellent solubility in water. The chemical structures of compounds (3) and (4) were determined using 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, as well as high-resolution mass spectrometry with electrospray ionization (ESI). To evaluate their potential as anticancer agents, in vitro assays were conducted using three human cancer cell lines (A549, Hep-G2, SW480) and one murine cancer cell line (B16F10). These compounds, along with indirubin (1) and Bortezomib (BTZ), were tested. The results revealed that compounds (3) and (4) demonstrated significant antitumor activity against all four cancer cell lines, with concentrations ranging from 0.363 to 12.990 µM. Importantly, their activity surpassed that of indirubin (1) and BTZ. Furthermore, an in vivo anticancer activity assay was performed on compound (4) using the B16F10 cell line. After 18 days, the tumor size in the group treated with compound (4) was approximately eight times smaller than that of the control group, and nearly three times smaller than the group treated with BTZ.
Over-Pressured Layer Chromatography and QSARs in predicting pharmacokinetics and toxicity of new herbicide candidates
Authors: Śliwińska Anna , Janicka Małgorzata 
Published: June 2023

Abstract
The Quantitative Structure-Activity Relationships (QSAR) methodology was utilized to predict the biological properties, including protein binding, plasma and brain unbound fractions, blood-brain barrier permeability, intestinal permeability, and lethal dose, of a series of newly synthesized s-triazines considered as potential herbicides. The Over-Pressured Layer Chromatography (OPLC) technique, employing reversed-phase systems, was applied to determine the lipophilicities of the substances, characterized by the retention parameters RM0. In the QSAR methodology, the chromatographic lipophilicity parameters (RM0), along with polarizability (α) and molecular weight (MW), were used as independent variables. Multiple linear regression was employed to derive the Quantitative Structure-Activity Relationships, which were subsequently validated, and their statistical significance was demonstrated.
Evaluation of sexual function in females with chronic hepatitis C virus and its correlation with medical parameters
Authors: alashry shereen 
Published: June 2023

Abstract
Hepatitis C virus (HCV) infection has a high prevalence in Egypt. The sexual function of female patients with chronic HCV has not been adequately studied in Egypt, where discussion of sexual desires and function is considered unacceptable by many. This study aims to evaluate sexual function in females with chronic HCV and its correlation with medical parameters. 120 female patients with chronic HCV and 120 healthy female controls were involved in the study. The Arabic validated version of Female Sexual Function Index (FSFI) was used to assess the sexual function of the patients and controls. There was a significant decrease in all domains of the FSFI score (desire, excitement, lubrication, orgasm, satisfaction and pain) in female patients with chronic HCV versus the control candidates. We found significant correlation between FSFI domains and haemoglobin level, leucocytic and platelet counts. However, the correlation between FSFI domains and serum HCV RNA, alanine transaminase (ALT) were stastistically non- significant. Being worker, having HCV + ve partner, having an old aged partner, presence of finantial stress and duration > 2 years since HCV diagnosis, all were associated with significant increase in female sexual dysfunction in chronic hepatitis C patients.
Preoperative prognostic model for localized and locally advanced renal cell carcinoma—Michinoku Japan Urological Cancer Study Group
Authors: Horie Shigemitsu , NAITO SEI , Hatakeyama Shingo , Kandori Shuya , Numakura Kazuyuki , Kato Renpei , Koguchi Tomoyuki , Myoen Shingo , Kawasaki Yoshihide , Ito Akihiro , Adachi Hisanobu , Kojima Yoshiyuki , Obara Wataru , Habuchi Tomonori , Nishiyama Hiroyuki , Ohyama Chikara , Tsuchiya Norihiko 
Published: June 2023

Abstract
Background
The Modified International Metastatic Renal Cell Carcinoma Dataset Consortium model (mIMDC) is a preoperative prognostic model for pT3cN0M0 renal cell carcinoma (RCC). This study aimed to validate the mIMDC and to construct a new model in a localized and locally advanced RCC (LLRCC).
Methods
A database was established (the Michinoku Japan Urological Cancer Study Group database) consisting of 65 patients who were clinically diagnosed with LLRCC (cT3b/c/4NanyM0) and underwent radical nephrectomy from December 2007 to May 2018. Using univariable and multivariable analyses, we retrospectively analyzed disease-free survival (DFS) and overall survival (OS) in this database, constructed a new prognostic model according to these results, and estimated the model fit using c-index on the new and mIMDC models.
Results
Independent poorer prognostic factors for both DFS and OS include the following: ≥1 Eastern Cooperative Oncology Group performance status, 2.0 mg/dL C-reactive protein, and > upper normal limit of white blood cell count. The median DFS in the favorable (no factor), intermediate (one factor), and poor-risk group (two or three factors) was 101.8, 18.2, and 4.0 months, respectively (P < 0.001). The 3-year OS in the favorable, intermediate, and poor-risk group were 100%, 54%, and 0%, respectively (P < 0.001). The c-indices of the new and mIMDC models were 0.73 and 0.66 for DFS (P = 0.065) and 0.86 and 0.73 for OS (P = 0.006), respectively.
Conclusion
The new preoperative prognostic model in LLRCC can be used in patient care and clinical trials.