bluuebunny/crossref_metadata_2025_split huggingface dataset:
The location of unilateral axillary lymphadenopathy after COVID-19 vaccination compared with that of metastasis from breast cancer without vaccination
Authors: Mukai Kiyoko , Tsunoda Hiroko , Imai Ryosuke , Numata Akiko , Kida Kumiko , Oba Ken , Yagishita Kazuyo , Yamauchi Hideko , Kanomata Naoki , Kurihara Yasuyuki 
Published: January 2023

Abstract
Purpose
Unilateral axillary lymphadenopathy is known to occur after coronavirus disease (COVID-19) vaccination. Post-vaccination lymphadenopathy may mimic the metastatic lymph nodes in breast cancer, and it is challenging to distinguish between them. This study investigated whether the localization of axillary lymphadenopathy on magnetic resonance imaging (MRI) could be used to distinguish reactive lymphadenopathy after COVID-19 vaccines from metastatic nodes.

Materials and methods
We retrospectively examined preoperative MRI images of 684 axillae in 342 patients who underwent breast cancer surgery from June to October 2021. Lymphadenopathy was defined as cortical thickening or short axis ≥ 5 mm. The axilla was divided into ventral and dorsal parts on the axial plane using a perpendicular line extending from the most anterior margin of the muscle group, including the deltoid, latissimus dorsi, or teres major muscles, relative to a line along the lateral chest wall. We recorded the presence or absence of axillary lymphadenopathy in each area and the number of visible lymph nodes.

Results
Of 80 axillae, 41 and 39 were included in the vaccine and metastasis groups, respectively. The median time from the last vaccination to MRI was 19 days in the vaccine group. The number of visible axillary lymph nodes was significantly higher in the vaccine group (median, 15 nodes) than in the metastasis group (7 nodes) (P < 0.001). Dorsal lymphadenopathy was observed in 16 (39.0%) and two (5.1%) axillae in the vaccine and metastasis groups, respectively (P < 0.001). If the presence of both ventral and dorsal lymphadenopathy is considered indicative of vaccine-induced reaction, this finding has a sensitivity of 34.1%, specificity of 97.4%, and positive and negative predictive values of 93.3％ and 58.5%, respectively.

Conclusion
The presence of deep axillary lymphadenopathy may be an important factor for distinguishing post-vaccination lymphadenopathy from metastasis. The number of axillary lymph nodes may also help.
Preoperative Serum Cortisol Level Is Predictive of Weight Loss After Laparoscopic Sleeve Gastrectomy in Men with Severe Obesity but Not Women
Authors: Bando Hironori , Miura Hiroshi , Kitahama Seiichi , Nakajima Shinsuke , Takahashi Tetsuya , Mihara Toshihiko , Momono Teppei , Kimura-Koyanagi Maki , Sakaguchi Kazuhiko , Mukai Tomoichiro , Ogawa Wataru , Tamori Yoshikazu 
Published: January 2023

Abstract
Background
Bariatric surgery is an effective treatment for severe obesity and its associated medical problems. Preoperative factors that predict postoperative weight loss remain to be fully characterized, however.

Methods
Anthropometric and laboratory data were collected retrospectively for severely obese patients who underwent laparoscopic sleeve gastrectomy (LSG) between April 2016 and July 2019 at our hospital. Preoperative factors that predicted weight loss at 1 year after LSG were investigated.

Results
A total of 122 subjects (45 men and 77 women) underwent LSG. The mean ± SD age and body mass index at surgery were 44.4 ± 10.4 years and 40.7 ± 6.7 kg/m2. The percent total weight loss (%TWL) was 27.0 ± 8.6 among all subjects, 26.4 ± 8.0 among men, and 27.4 ± 8.9 among women, with no significant difference between the sexes. The %TWL showed a significant inverse correlation with serum cortisol level in men and with age and the visceral/subcutaneous fat area ratio in women. Multivariable regression analysis revealed the presence of type 2 diabetes and the serum cortisol concentration to be negatively associated with %TWL among all subjects and men, respectively. Receiver operating characteristic curve analysis identified an optimal cutoff of 10 µg/dL for prediction of a %TWL of ≥ 25 in men by serum cortisol level.

Conclusions
Serum cortisol concentration was identified as a predictor for postoperative weight loss in men. Our results may thus help inform the decision to perform LSG or more effective surgical procedures in men with severe obesity.

Graphical Abstract
Automated process planning in milling of hybrid components
Authors: Denkena Berend , Wichmann Marcel , Heide Klaas Maximilian , Wiesener Frederik , Nguyen Hai Nam 
Published: January 2023

AbstractHybrid material composites can meet the increasing demands for high strength and low weight due to their different workpiece properties. Usually, hybrid components require post-machining after their fabrication. Due to the different material properties, new challenges arise in the machining process. It is essential to recognize the course of the material boundary in order to adapt the process planning accordingly and to enable a uniform material transition during machining. This paper presents a method for automated material recognition and automatic adaptation of the process parameters considering a uniform force level during the milling of hybrid materials. This way, the load on the milling tool in the material transition area can be reduced by up to 71%, which prevents premature tool failure. An optical laser line scanner is used to localize of material transitions within hybrid components. This enables a digital mapping of the material distribution in the discretized workpiece model. In combination with an empirical force model, it is possible to predict the cutting forces of the different materials and determine the material transition area for adapting them to specified target values.
Carbon Stocks in Vegetation and Soil and Their Relationship with Plant Community Traits in a Mediterranean Non-tidal Salt Marsh
Authors: Carrasco-Barea Lorena , Verdaguer Dolors , Gispert Maria , Font Joan , Compte Jordi , Llorens Laura 
Published: January 2023

AbstractSalt marshes are considered among the ecosystems with the highest capacity for carbon sequestration. However, studies have mainly focused on tidal salt marshes, while knowledge about non-tidal salt marshes, which prevail in the Mediterranean Basin, is currently scarce. Consequently, we aimed to (1) estimate the carbon stocks of the vegetation, litter, and soil of three natural Habitats of Community Interest of a Mediterranean non-tidal salt marsh–a halophilous scrub, a salt meadow, and a glasswort sward–and (2) determine how differences in floristic composition and community structure among habitats over 1 year are related to the amount and distribution of carbon stored in plants and soils. Results show that the halophilous scrub and the salt meadow were constituted by mature plant communities with overall stable carbon stocks in the vegetation, litter, and soil (0–20 cm), which were approximately 4 and 2.5 times larger, respectively, than those found in the glasswort sward (1013 ± 40 g C m−2). However, while the salt meadow and the glasswort sward had more carbon stored in the soil than in the vegetation (approximately 3 and 7.5 times more, respectively), the halophilous scrub had similar amounts in both compartments (2248 ± 388 and 1566 ± 179 g C m−2 in the soil and vegetation, respectively). Sarcocornia fruticosa represented 93.5% of the total plant biomass of the halophilous scrub, which highlights the importance of this species in maintaining carbon stocks in this Mediterranean non-tidal salt marsh.
Development and Optimization of a Multilayer Rat Purkinje Neuron Culture
Authors: Uggerud Ida Margrethe , Kråkenes Torbjørn , Hirai Hirokazu , Vedeler Christian Alexander , Schubert Manja 
Published: January 2023

Abstract
Elucidation of the mechanisms involved in neurodegenerative diseases of the cerebellum has been hampered by the lack of robust single cell models to study Purkinje neurons and replicate at the same time in vivo features. Cerebellar Purkinje neurons are difficult to grow in dispersed cell culture, and only limited work has been done using rat cells. We developed a refined protocol for growing rat Purkinje neurons from embryonic and postnatal tissue ex vivo that results in well-developed, mature, functional, and synaptically active neurons. The rat Purkinje neurons generated are responsive to paracrine factors and genetic manipulation, allowing great experimental flexibility at the single-cell level. This ex vivo model can be used to investigate disease mechanisms that disturb Purkinje neuron morphology, function, and communication in high- and low-throughput screening formats.
An estate at Zincirli? Land use and resource exploitation at the Middle Bronze Age monumental building Complex DD in Zincirli, Gaziantep Province of Turkey
Authors: Deckers Katleen , Karakaya Doga , Poolman Laurel , Öğüt Birgül , Herrmann Jason , Morgan Kathryn R. , Herrmann Virginia 
Published: January 2023

AbstractNear Eastern monumental buildings once hosted institutions with a variety of economic and environmental footprints. In this article examining a Middle Bronze Age II (seventeenth century BC) building complex at Zincirli, Turkey, we integrate bioarchaeological remains with ceramic and artifactual evidence to evaluate whether this building was a specialized node in a broader network and centralized economy. Combining seed/fruit/chaff analysis with charcoal, phytolith, diatom, and spherulite investigations and zooarchaeology allows for a more holistic identification of the building’s environmental and economic catchments. The pronounced presence of conifer, probably related to the building’s architecture, suggests an elite function of the complex. A broad range of activities took place within the complex, such as the preparation, storage, and consumption of different food and drink products, alongside craft activities. There is evidence for centralized storage of diverse crops and production of wine and textiles. The building seems to have functioned as a kind of estate, possessing access to large areas of land. The bioarchaeological remains evidence the exploitation of the varied environments surrounding the site, where economically valuable resources were locally available and exploited, such as cedar, pine, grapes, and large hunting game. Complex DD provides evidence of wetland exploitation, agropastoral production, wood procurement, and hunting in the semi-steppe batha environments of the Islahiye plain and the woodland forests of the Amanus.
Introduced species in a tidal ecosystem of mud and sand: curse or blessing?
Authors: Reise Karsten , Buschbaum Christian , Lackschewitz Dagmar , Thieltges David W. , Waser Andreas M. , Wegner K. Mathias 
Published: January 2023

AbstractFor about a century, biodiversity in the tidal Wadden Sea (North Sea, European Atlantic) has increased by more than one hundred introduced species from overseas. Most originate from warmer waters and could facilitate the transformation of this coastal ecosystem to comply with climate warming. Some introduced species promote sediment stabilization and mud accretion. This could help tidal flats to keep up with sea level rise. Although some introduced species also entail negative effects, introductions have diversified lower food web levels, and may benefit foraging birds. So far, no resident populations have gone extinct because an introduced species had established. Rather than degrading the ecosystem, the establishment of introduced species seems to have raised the capacity to follow environmental change. We support increasing efforts against introductions to avoid risk. However, once species are integrated, the common condemnation attitude against “non-natives” or “aliens” ought to be reconsidered for tidal ecosystems of low biodiversity.
Sepedonium sp. and Phellinus sp. Novel Isolates: Growth Pattern and Production of Polysaccharide-Protein Complexes on Conventional and Grape Pomace Substrates
Authors: Kachrimanidou Vasiliki , Papadaki Aikaterini , Alexandri Maria , Poulios Vaggelis , Gonou-Zagou Zacharoula , Kopsahelis Nikolaos 
Published: January 2023

Abstract
Purpose
The growth behavior of novel fungal isolates along with the production of bioactive compounds from mycelia mass during submerged fermentations were investigated using conventional synthetic media and agro-industrial residues as fermentation substrates.

Methods
Four novel isolated fungi, belonging to edible or medicinal species, were evaluated for their ex-situ growth on potato dextrose agar. Specific attention was designated to Sepedonium sp. and Phellinus sp. considering their high growth rate in solid state fermentations. Submerged fermentations were subsequently employed using synthetic carbon sources (glucose, fructose and lactose) to assess the fermentation behavior. Following the better growth pattern on glucose and fructose, compared to lactose, grape pomace extract (GPE) was applied as nutrient feedstock to assess the production of biomass and bioactive compounds. Aqueous extraction was performed to obtain crude intracellular polysaccharides (IPS), that were subsequently characterized in terms of antioxidant activity, protein and polysaccharide content.

Results
Sepedonium sp. demonstrated the highest biomass production; 11.4 and 10.5 g/L, using glucose and fructose, respectively, whereas Phellinus yielded up to 3.8 g/L. Lactose was also assimilated by both fungal strains, however biomass production was lower. Utilization of GPE affected biomass production; Sepedonium sp. biomass decreased, whereas biomass obtained from Phellinus sp. was enhanced, compared to synthetic sugars. Crude IPS extracts elicit high antioxidant activity (> 75% inhibition of DPPH• free radical).

Conclusion
The successful application of conventional and renewable substrates for Sepedonium and Phellinus fermentation was demonstrated, while the mycelia mass derived polysaccharide-protein complexes exhibited bioactive properties, and thus might be utilized as functional food components.

Graphical Abstract
Improvement of Korea Meteorological Administration Solar Energy Resources Map Using Fine-Scale Terrain Data
Authors: Yun Jinah , Kim Jinwon , Choi Minwoo , Choi Hee-Wook , Kim Yeon-Hee , Lee Sang-Sam 
Published: January 2023

AbstractReal-time solar energy resources mapping is crucial for the development and management of solar power facilities. This study analyzes the effects of the digital elevation model (DEM) resolution on the accuracy of the surface insolation (insolation hereafter) calculated by the Korea Meteorological Administration solar energy mapping system, KMAP-Solar, using two DEMs of different resolutions, 1.5 km and 100 m. It is found that KMAP-Solar yields smaller land-mean insolation with the fine-scale DEM than the coarse-scale DEM. The fine-scale DEM reduces biases by as much as 32 Wm− 2 for all observation sites, especially those in complex terrain and that the insolation error reduction is correlated with the difference in sky view factor (SVF) between the coarse- and fine-scale DEM. Both the coarse- and fine-scale DEMs generate the insolation-elevation and insolation-SVF relationship which is characterized by positive (negative) correlation between the insolation and the terrain altitude (SVF). However, the coarse-scale DEM substantially underestimates these relationships compared to the fine-scale DEM, mainly because the coarse-scale DEM underrepresents large terrain slopes and/or small SVFs, most seriously in high-altitude regions. The fine-scale DEM generates a more realistic insolation distribution than the coarse-scale DEM by incorporating a wider range of key terrain parameters involved in determining insolation. Improvements of insolation calculations in KMAP-Solar using a fine-scale DEM, especially in the areas of complex terrain, is of a practical value for Korea because the operational solar resources map from KMAP-Solar supports solar energy research, solar power plant installations, and real-time prediction and management of solar power within the power grid.
Study Physicochemical and Thermal Properties of Eco-friendly Lightweight Geopolymers Incorporating Silica Sand Flour
Authors: Abbas Ahmed M. , Sultan Mohamed E. , Khater Hisham M. , Abd El-razik Mahmoud M. , El-Nawawy Mohamed A. , Sayed Ahmed Z. 
Published: January 2023

AbstractLow-cost lightweight geopolymer mortars based on water-cooled slag, fly ash, and silica sand flour were prepared as a structural and thermally insulating material. The effect of chemical foaming agents such as hydrogen peroxide (H2O2) and sodium perborate tetrahydrate (NaBO3·4H2O) on thermal conductivity, bulk density, water absorption, porosity, and compressive strength was studied. FTIR, XRD, XRF, and SEM were used to investigate the raw materials and selected samples of prepared lightweight geopolymers. The prepared lightweight geopolymers were given a compressive strength of 1.05 to 17 MPa. The compressive strength, bulk density, and thermal conductivity values decrease with increasing foaming agent content due to the decomposition of its chemical structure and releasing of oxygen bubbles. The results show that hydrogen peroxide mixes have better performance in the physio-chemical and thermal properties than sodium perborate mixes to achieve low thermal conductivity (0.21–0.24 W/mK) with compressive strength values (1.18–3.45 MPa) for MS-H1 and MS-H2 mixes, respectively. According to the results of bulk density (454–800 kg/m3), MS-H1, MS-H2, MS-B3, and MS-B4 mixes can be considered ultra-lightweight. Using silica sand flour in powder form improves the physicochemical and thermal properties of the lightweight geopolymer and decreases the production cost of the lightweight geopolymers.
Making primary healthcare delivery robust for low resource settings: Learning from Mohalla Clinics
Authors: Akhtar Md Haseen , Ramkumar Janakarajan 
Published: January 2023

AbstractThe present healthcare scenario is still in its compromised state, whether it is the lack of infrastructure, medicines and human resources, especially in rural India. Moreover, the condition worsens in rural areas due to several reasons like lack of awareness, proper roads to access, and lack of proper delivery of healthcare model. The state government of Delhi, India, set up the “Mohalla” Clinics to provide essential healthcare to residents of Delhi and the surrounding areas, focusing on the urban poor. Essential health services, such as vaccinations, family planning, and counselling, are available at the Mohalla Clinics, where a doctor, a nurse, a pharmacist, and a lab technician are staffed. Despite a strong start and low operating costs, the Mohalla Clinic initiative still struggles to cover all Delhi state as envisioned. This study analyses the operational challenges of Delhi’s “Mohalla” Clinics and proposes lessons to be implemented for other primary healthcare infrastructure services for remote areas. The analysis is based on the systems (infrastructure, facilities, and services) strengths and limitations from a literature review and qualitative interview conducted among 55 respondents, including doctors, nurses, and patients among 11 Mohalla Clinics using the SUTD-MIT (Singapore University of Technology and Design—Massachusetts Institute of Technology Industrial Design Centre) interview template for Product Service System (PSS). The results show that there are lessons to learn from the model of Delhi Mohalla Clinics for other states to implement in their primary healthcare sectors. To achieve Universal Health Coverage (UHC), the Delhi Mohalla Clinic falls short due to several limitations. Thus, to achieve UHC, the Indian healthcare system needs a new healthcare delivery model. Hence, we ought to propose a new healthcare delivery model based on the gained insights from the study. One such delivery model proposed is a mobile Primary Health Center (mPHC). This collapsible system can be taken to far-flung regions, deployed for some hours, run the Out-Patient Department (OPD), collapsed, and returned to base.
Outcome of Transplant Recipients Infected with Omicron BA.1 and BA.2: A Single-Center Retrospective Study in Saudi Arabia
Authors: Alshukairi Abeer N. , Aldabbagh Yasser , Adroub Sabir A. , Mourier Tobias , Abumelha Khalid Y. , Albishi Ghadeer E. , Alraddadi Basem M. , Al Hroub Mohammad K. , El-Saed Aiman , Ibrahim Suzan M. Nagash , Al Musawa Mohammed , Almasari Ahlam , Habahab Wael T. , Alhamlan Fatimah S. , Al-Omari Awad , Pain Arnab , Dada Ashraf 
Published: January 2023

AbstractThe outcome of transplant recipients is variable depending on the study population, vaccination status and COVID-19 variants. Our aim was to study the impact of Omicron subvariants on the mortality of transplant recipients. We reviewed the results of SARS-CoV-2 whole genome sequence of random isolates collected from 29 December 2021 until 17 May 2022 in King Faisal Specialist Hospital and Research center, Jeddah (KFSHRC-J), Saudi Arabia performed as hospital genomic surveillance program for COVID-19 variants. We included 25 transplant patients infected with confirmed Omicron variants.17 (68%) and 8 (32%) patients had Omicron BA.1 and BA.2, respectively. 12 (68%) patients had renal transplants. Only 36% of patients received three doses of COVID-19 vaccines. 23 (92%) patients required hospitalization. 20 (80%) patients survived and 6 (25%) required intensive care unit (ICU) admission. Among ICU patients, 66.7% were more than 50 years, 50% had two to three comorbidities and 5 out of 6 (83%) died. The mortality of transplant patients infected with Omicron variants in our cohort was higher than other centers as a limited number of patients received booster vaccines. Optimizing booster vaccination is the most efficient method to improve the mortality of COVID-19 in transplant recipients recognizing the inefficacy of monoclonal antibodies in the presence of SARS-CoV-2 emerging variants. We did not show a difference in mortality in transplant patients infected with Omicron BA.1 and BA.2 knowing the limitation of our sample size.