bluuebunny/crossref_metadata_2025_split huggingface dataset:
Community Health Center Staff Perspectives on Financial Payments for Social Care
Authors: LOPEZ JUSTIN M. , WING HOLLY , ACKERMAN SARA L. , HESSLER DANIELLE , GOTTLIEB LAURA M. 
Published: August 2023

Policy Points
State and federal payers are actively considering strategies to increase the adoption of social risk screening and interventions in health care settings, including through the use of financial incentives.
Activities related to social care in Oregon community health centers (CHCs) provided a unique opportunity to explore whether and how fee‐for‐service payments for social risk screening and navigation influence CHC activities.
CHC staff, clinicians, and administrative leaders were often unaware of existing financial payments for social risk screening and navigation services. As currently designed, fee‐for‐service payments are unlikely to strongly influence CHC social care practices.
ContextA growing crop of national policies has emerged to encourage health care delivery systems to ask about and try to address patients’ social risks, e.g., food, housing, and transportation insecurity, in care delivery contexts. In this study, we explored how community health center (CHC) staff perceive the current and potential influence of fee‐for‐service payments on clinical teams’ engagement in these activities.MethodsWe interviewed 42 clinicians, frontline staff, and administrative leaders from 12 Oregon CHC clinical sites about their social care initiatives, including about the role of existing or anticipated financial payments intended to promote social risk screening and referrals to social services. Data were analyzed using both inductive and deductive thematic analysis approaches.FindingsWe grouped findings into three categories: participants’ awareness of existing or anticipated financial incentives, uses for incentive dollars, and perceived impact of financial incentives on social care activities in clinical practices. Lack of awareness of existing incentives meant these incentives were not perceived to influence the behaviors of staff responsible for conducting screening and providing referrals. Current or anticipated meaningful uses for incentive dollars included paying for social care staff, providing social services, and supporting additional fundraising efforts. Frontline staff reported that the strongest motivator for clinic social care practices was the ability to provide responsive social services. Clinic leaders/managers noted that for financial incentives to substantively change CHC practices would require payments sizable enough to expand the social care workforce as well.ConclusionsSmall fee‐for‐service payments to CHCs for social risk screening and navigation services are unlikely to markedly influence CHC social care practices. Refining the design of financial incentives—e.g., by increasing clinical teams’ awareness of incentives, linking screening to well‐funded social services, and changing incentive amounts to support social care staffing needs—may increase the uptake of social care practices in CHCs.
The PURPOSe cause of death study in stillbirths and neonatal deaths in India and Pakistan: A review
Authors: Goldenberg Robert L. , Saleem Sarah , Goudar Shivaprasad S. , Moore Janet , Guruprasad Gowdar , Kulkarni Vardendra , Dhaded Sangappa M. , Tikmani Shiyam Sunder , Nausheen Sidrah , Masheer Shazia , Kallapur Mangala G. , Ghanchi Najia K. , Harakuni Sheetal U. , Ahmed Imran , Hwang Kay , Yogeshkumar S. , Somannavar Manjunath S. , Yasmin Haleema , Kim Jean , Bann Carla M. , Silver Robert M. , McClure Elizabeth M. ,   the PURPOSe Study Group
Published: August 2023

AbstractThe PURPOSe study was a prospective, observational study conducted in India and Pakistan to determine the cause of death for stillbirths and preterm neonatal deaths, using clinical data together with minimally invasive tissue sampling (MITS) and the histologic and polymerase chain reaction (PCR) evaluation of fetal/neonatal tissues and the placenta. After evaluating all available data, an independent panel chose a maternal, a placental and a fetal/neonatal cause of death. Here, we summarise the major results. Among the most important findings were that most stillbirths were caused by fetal asphyxia, often preceded by placental malperfusion, and clinically associated with pre‐eclampsia, placental abruption and a small‐for‐gestational‐age fetus. The preterm neonatal deaths were primarily caused by birth asphyxia, followed by various infections. An important finding was that many of the preterm neonatal deaths were caused by a nosocomial infection acquired after neonatal intensive care (NICU) admission; the most common organisms were Acinetobacter baumannii, followed by Klebsiella pneumoniae, Escherichia coli/Shigella and Haemophilus influenzae. Group B streptococcus was less commonly present in the placentas or internal organs of the neonatal deaths.
Updated evidence of beneficial effect of LDL apheresis for refractory nephrotic syndrome due to a variety of causative diseases for nationwide and global approval
Authors: Muso Eri , Kakita Hiroko , Suzuki Hiroyuki , Tsukamoto Tatsuo 
Published: August 2023

AbstractLow‐density lipoprotein apheresis (LDL‐A) therapy has shown reasonable efficacy in treating nephrotic syndrome (NS) refractory to initial drug therapy and has been covered by National Health Insurance for the indication of drug‐resistant focal segmental glomerulosclerosis (FSGS) since 1992 in Japan and has contributed to liberating substantial number of patients of this disease from entering into end‐stage renal disease by easier practical application in actual clinical settings. Subsequently, various beneficial evidence of this treatment has accumulated on those other than FSGS, however, due to the limitation of covered disease insurance only for FSGS, patients with diseases other than FSGS are unlikely to benefit from this treatment in practice. This review summarizes the therapeutic evidence of the beneficial effect of LDL‐A accumulated to date and the mechanisms of action analyzed from multifaceted perspectives. examines the applicability of expanding insurance coverage for diseases other than FSGS.
Effect of pulsed light on myofibrillar protein of large yellow croaker (Pseudosciaena crocea) during refrigerated storage
Authors: Zhang Jianyou , Ji Shengqiang , Zhou Guangcheng , Cui Pengbo , Miao Li , Chen Yutong , Lyu Fei , Ding Yuting 
Published: August 2023

AbstractThis study mainly evaluated the effect of different energies of pulsed light (PL) treatment (100, 200, 300, 400, and 500 J/pulse) on myofibrillar protein (MP) of large yellow croaker during refrigerated storage. The results showed that PL treatment would cause a certain degree of oxidation to the MP of large yellow croaker at the initial stage, which showed that the total sulfhydryl content of the protein decreased, the carbonyl content and the average particle size increased, and the β‐sheet to β‐turn transformation, the tertiary structure of the protein unfolds, and the hydrophobic groups were exposed, causing the reduction of intrinsic fluorescence intensity. However, subsequent storage studies found that PL treatment could slow down the oxidation rate of MP. The decrease rate of total sulfhydryl content and the increase rate of carbonyl content in the 300 J/pulse group were both reduced by about 1.7 times compared with the control group. At the same time, the PL treatment with this intensity could also better protect the secondary structure, tertiary structure, and microstructure of MP. This study provided theoretical basis and reference for analyzing the quality change rule and mechanism of large yellow croaker during refrigerated storage after PL treatment. Studies have shown that PL treatment can reduce the adverse changes of MP in large yellow croaker during cold storage.
Is low‐dose tumor necrosis factor inhibitor effective and safe in patients with ankylosing spondylitis flare‐up after renal transplantation? A case report and literature review
Authors: Leong Pui‐Ying , Shih Po‐Cheng , Huo An‐Ping 
Published: August 2023

AbstractRheumatic diseases, the immunosuppressant drugs used after solid organ transplantation to prevent graft rejection, and the biologics used for controlling rheumatic disease, especially tumor necrosis factor inhibitors (TNFi)—all of these could increase the risk of malignancy. The roles of biologics for disease control in rheumatic disease patients after kidney transplantation (KT) are not well established because only a few cases are reported, and the possibility of increasing infection and malignancy rates. Here, we present the first case of ankylosing spondylitis (AS) successfully treated with low‐dose TNFi for disease activity flare‐up 5 months after KT and review the literature to see whether the use of biologics, especially TNFi, in AS patients with disease activity flare‐ups after receiving KT is effective and safe.
Second‐chance offers and buyer reputation systems: theory and evidence on auctions with default
Authors: Engelmann Dirk , Frank Jeff , Koch Alexander K. , Valente Marieta 
Published: August 2023

AbstractWinners in online auctions frequently fail to complete purchases. Major auction platforms therefore allow “second‐chance” offers (the runner‐up bidder pays his own bid price) and let sellers leave negative feedback on buyers who default. We show theoretically that (i) all else equal, the availability of second‐chance offers reduces bids; (ii) sellers have no incentive to exclude bidders, even if they are nearly certain to default; (iii) buyer reputation systems reward bidders known to default with a positive probability. Our experiments show that the economic forces identified in the theoretical model are important enough to have predictive power for bidder behavior.
Bloom syndrome patients and mice display accelerated epigenetic aging
Authors: Lee Jamie , Zhang Joshua , Flanagan Maeve , Martinez Julian A. , Cunniff Christopher , Kucine Nicole , Lu Ake T. , Haghani Amin , Gordevičius Juozas , Horvath Steve , Chang Vivian Y. 
Published: August 2023

AbstractBloom syndrome (BSyn) is an autosomal recessive disorder caused by variants in the BLM gene, which is involved in genome stability. Patients with BSyn present with poor growth, sun sensitivity, mild immunodeficiency, diabetes, and increased risk of cancer, most commonly leukemias. Interestingly, patients with BSyn do not have other signs of premature aging such as early, progressive hair loss and cataracts. We set out to determine epigenetic age in BSyn, which can be a better predictor of health and disease over chronological age. Our results show for the first time that patients with BSyn have evidence of accelerated epigenetic aging across several measures in blood lymphocytes, as compared to carriers. Additionally, homozygous Blm mice exhibit accelerated methylation age in multiple tissues, including brain, blood, kidney, heart, and skin, according to the brain methylation clock. Overall, we find that Bloom syndrome is associated with accelerated epigenetic aging effects in multiple tissues and more generally a strong effect on CpG methylation levels.
Distance to the edge and other landscape features influence nest predation in grey partridges
Authors: Laux A. , Mayer K. , Beeke W. , Waltert M. , Gottschalk E. 
Published: August 2023

AbstractPredation and habitat deterioration are the main reasons for the strong decline of ground‐nesting farmland birds such as the grey partridge Perdix perdix in Europe. Grey partridge nests and incubating females are especially vulnerable to predation. We have previously demonstrated that predator activity is much lower inside flower blocks (agri‐environment schemes sown with a flower seed mix) than at their edges and that predator activity in flower blocks depends on the surrounding landscape. Here, we investigate whether these differences in predator activity translate into differences in grey partridge nest predation and assess predation patterns relative to landscape and nest site characteristics. We recorded the success of 56 nests of radio‐tagged grey partridges between 2009 and 2017 in an agricultural landscape in Central Germany. We used Bayesian logistic regression to analyse the effects of nest site and landscape characteristics on nest predation on a subset of 46 nests (21 nests successful, 25 predated). Distance to the edge of the nesting habitat was the most important predictor, reducing predation probability from 66.8% at the edge to 18.5% at 85.5 m. Predation probability decreased with increasing length of habitat borders, habitat diversity and the area of permanent grasslands and fallows. Predation probability was higher further from settlements and increased with increasing woodland area in the agricultural matrix. When considering linear landscape structures, nest predation patterns matched the patterns of predator activity from our previous studies. Results suggest that the distance to the edge of the nesting habitat is most important and that nest predation may be reduced by providing sufficiently broad nesting habitats. Nest predation may further be minimized by increasing habitat diversity and coverage of extensive vegetation types and by establishing conservation measures for grey partridges further away from woodlands. These measures may also benefit other ground‐nesting farmland birds.
Cyclic fatigue resistance of different nickel‐titanium instruments in single and double curvature at room and body temperatures: A laboratory study
Authors: La Rosa Giusy Rita Maria , Leotta Maria Laura , Canova Francesco Saverio , Romeo Virginia Rosy , Cervino Gabriele , Generali Luigi , Pedullà Eugenio 
Published: August 2023

AbstractThe aim of this study was to compare the cyclic fatigue resistance of nickel‐titanium instruments inside single and double‐curved canals at different temperatures. 160 HyFlex EDM #20.05 (HEDM), VDW.ROTATE #20.05 and #25.06, Mtwo #25.06 were randomised (n = 10) for the dynamic cyclic fatigue tests according to the curvature (i.e. single and double) at 20° ± 1°C and 35° ± 1°C. The number of cycles to fracture (NCF) was analysed by two‐way ANOVA with p < 0.05. Fatigue resistance of all instruments significantly decreased at body temperature in single and double curvatures, except for HEDM in double curvature. The NCF was significantly lower in double curvature than single at both temperatures for all files, except for VDW.ROTATE #20.05 at 35° ± 1°C. Within the study limitations, temperature significantly impaired cyclic fatigue resistance of all files except HEDM #20.05 in double curvature. Similarly, double curvature had a detrimental effect on cyclic fatigue resistance of all files except for VDW.ROTATE #20.05 at body temperature.
Current trends in non‐surgical management of Peyronie's disease—A narrative review
Authors: Kozub Anna , Suleja Agata , Chłosta Marcin , Kupilas Andrzej , Pradere Benjamin , Rivas Juan Gómez , Rajwa Paweł , Miszczyk Marcin 
Published: August 2023

AbstractPeyronie's disease (PD) is a connective tissue disorder affecting the tunica albuginea. It can cause pain and penile deformation, and its prevalence increases with age. Although surgery is the gold standard for the chronic phase of the disease, there are several conservative treatment methods available, and the optimal management of the acute phase of the disease remains a matter of debate. In this article, we aim to summarize the recent trends in research on the subject of non‐surgical treatment of PD. The search was performed in PubMed, Scopus, and Web of Science databases and included studies in English published between 2012 and 2022 investigating the clinical outcomes of non‐surgical PD management in humans. We have identified 20 distinct conservative treatment strategies. Among the oral therapeutics, only the use of phosphodiesterase type 5 inhibitors is currently recommended for clinical use in patients with concomitant erectile dysfunction. The use of collagenase from Clostridium histolyticum is supported by the best quality evidence in terms of intralesional injections for patients suffering from significant penile curvature; however, interferon alpha‐2b can also be an option in such patients. Among other non‐invasive methods, extracorporeal shockwaves can be useful for pain reduction, and penile traction therapy can lead to a reduction in penile curvature and plaque size. Despite a wide range of non‐surgical methods available for PD treatment, the majority are not supported by sufficient scientific evidence, and the treatment efficacy is underwhelming. Further research on the subject of non‐surgical management of PD is highly warranted.
The impact of relative age effects on psychosocial development: A systematic review
Authors: Rose Sarah E. , Barlow Claire M. 
Published: August 2023

AbstractBackgroundWithin the same school class, it is usual to find children who differ in age by almost a full calendar year. Although associations between being relatively young and poor academic outcomes are well documented, and relatively consistent, the associations between being relatively young and psychosocial outcomes are less clearly documented.AimsTo review research which presents data relating to associations between a child's relative age and their psychosocial development.MethodsA systematic review was conducted and reported in accordance with PRISMA guidelines.ResultsFifty‐nine papers met the inclusion criteria. The outcomes of the narrative synthesis and three meta‐analyses found consistent, but very small, associations with relative age indicating that those who are relatively young are more likely to have more negative behaviour, mental well‐being, and social experiences.ConclusionsAlthough being relatively young is associated with more negative psychosocial outcomes, the magnitude of these associations is consistently small. Furthermore, many of the outcome measures used are likely to be the result of multiple influences, not limited to the effects of relative age. Therefore, the findings are reassuring as they suggest that relative age itself is unlikely to substantially increase an individual's risk of poor psychosocial development.
Supporting child and family resilience in the face of political violence: Evidence from a home visit parenting program
Authors: Leer Jane , Lopez Boo Florencia , Norman Savannah 
Published: August 2023

AbstractPolitical violence affects more than 25% of children globally, yet little is known about how to support positive adaptation among conflict‐affected children. Using a sample of 3797 Nicaraguan child‐caregiver dyads (MAgeTime1 = 1.5 years, MAgeTime2 = 5.9 years; 51% male), this registered report used a novel quasi‐experimental approach to examine how exposure to political violence relates to child and caregiver outcomes, and to test three policy‐relevant moderators: participation in a large‐scale home visit parenting program, household economic disruption, and media exposure. Results revealed positive associations between political violence and harsh discipline practices (0.33 SD), but there was no evidence that political violence affected children's behavior, caregiver depressive symptoms, or responsive parenting practices, and there was no evidence of moderation.
Registered Reports in Child Development: Introduction to the Special Section
Authors: Syed Moin , Frank Michael C. , Roisman Glenn I. 
Published: August 2023

AbstractRegistered Reports (RRs) are an emerging format for publishing empirical journal articles in which the decision to publish an article is based on sound conceptualization, methods, and planned analyses rather than the specific nature of the results. This article introduces the Special Section on Registered Reports in Child Development by describing what RRs are and why they are necessary, outlining the thought process that guided the Special Section, describing key thematic insights across the eight articles included in the collection, and providing recommendations for developmental researchers interested in publishing via the RR format. This article also serves as a formal announcement that RRs will be a standard publishing option at Child Development, effective immediately.
Extension domain of amyloid processor protein inhibits amyloidogenic cleavage and balances neural activity in a traumatic brain injury mouse model
Authors: Xie Zhenxing , Li Tianyu , Su Wei , Lou Yanyun , Zhang Yongsheng , Zhou Xiyuan , Li Zhanfei , Bai Xiangjun , Liu Xinghua 
Published: August 2023

AbstractBackgroundMechanisms underlying cognitive dysfunction following traumatic brain injury (TBI) partially due to abnormal amyloid processor protein (APP) cleavage and neural hyperactivity. Binding of the extension domain of APP (ExD17) to the GABAbR1 receptor results in reduced neural activity, which might play a role in the mechanisms of cognitive dysfunction caused by TBI.MethodsStretch‐induced injury was utilized to establish a cell injury model in HT22 cells. The TBI model was created by striking the exposed brain tissue with a free‐falling weight. Topical or intraperitoneal administration of ExD17 was performed. Cell viability was assessed through a cell counting kit‐8 assay, while intracellular Ca2+ was measured using Fluo‐4. Western blotting was used to investigate the expression of APP amyloidogenic cleavage proteins, GABAbR1, phospholipase C (PLC), PLCB3, and synaptic proteins. ELISA was performed to analyze the levels of Aβ42. Seizures were assessed using electroencephalography (EEG). Behaviors were evaluated through the novel object recognition test, open field test, elevated plus maze test, and nest‐building test.ResultsExD17 improved cell viability and reduced intracellular calcium in the cell injury model. The treatment also suppressed the increased expression of APP amyloidogenic cleavage proteins and Aβ42 in both cell injury and TBI models. ExD17 treatment reversed the abnormal expression of GABAbR1, GRIA2, p‐PLCG1/PLCG1 ratio, and p‐PLCB3/PLCB3 ratio. In addition, ExD17 treatment reduced neural activity, seizure events, and their duration in TBI. Intraperitoneal injection of ExD17 improved behavioral outcomes in the TBI mouse model.ConclusionsExD17 treatment results in a reduction of amyloidogenic APP cleavage and neuroexcitotoxicity, ultimately leading to an improvement in the behavioral deficits observed in TBI mice.
Analyzing the outcomes of China's ecological compensation scheme for development‐related biodiversity loss
Authors: Gao Shuo , Bull Joseph W. , Baker Julia , zu Ermgassen Sophus O. S. E. , Milner‐Gulland E. J. 
Published: August 2023

AbstractOver the past three decades, China's government has implemented many projects under its ecological compensation policy, including paying compensation fees for habitat creation to redress natural habitat losses caused by development. However, a critical evaluation of both the policy design and its ecological outcomes, has not previously been carried out. We assemble diverse data sources to provide the first evaluation of China's eco‐compensation policy and practice, identifying several challenges. In policy, the pricing of forest restoration fees is insufficient in several provinces, and there is no requirement for use of biodiversity metrics or for ecological equivalence of compensation and losses. In practice, only 23% of a sample of 31 developments applied quantitative biodiversity metrics, and fewer than 1% of China's local governments have disclosed information regarding compensation implementation. Thus, to improve the validity of its compensation policy and practice to better secure biodiversity, China may need to embrace higher compensation standards, having first prevented ecological losses where possible. Equally important, China may also need to improve compensation governance for data tracking and conservation effectiveness monitoring.