bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-Traumatic Cognitions Inventory (PTCI): psychometric properties in clients with serious mental illness and co-occurring PTSD
Authors: Lu Weili , Mueser Kim T. , Yanos Philip T. , Siriram Amanda , Jia Yuane , Leong Alyssa , Silverstein Steven M. , Gottlieb Jennifer , Jankowski Mary K. 
Published: May 2023

AbstractBackground:People with post-traumatic stress disorder (PTSD) exhibit negative cognitions, predictive of PTSD severity. The Post-Traumatic Cognitions Inventory (PTCI) is a widely used instrument measuring trauma-related cognitions and beliefs with three subscales: negative thoughts of self (SELF), negative cognitions about the world (WORLD), and self-blame (BLAME).Aims:The current study attempted to validate the use of the PTCI in people with serious mental illness (SMI), who have greater exposure to trauma and elevated rates of PTSD, using confirmatory factor analysis (CFA) and examining convergent and divergent correlations with relevant constructs.Method:Participants were 432 individuals with SMI and co-occurring PTSD diagnosis based on the Clinician Administered PTSD Scale, who completed PTCI and other clinical ratings.Results:CFAs provided adequate support for Foa’s three-factor model (SELF, WORLD, BLAME), and adequate support for Sexton’s four-factor model that also included a COPE subscale. Both models achieved measurement invariance at configural, metric and scalar levels for three diagnostic groups: schizophrenia, bipolar and major depression, as well as for ethnicity (White vs Black), and gender (male vs female). Validity of both models was supported by significant correlations between PTCI subscales, and self-reported and clinician assessed PTSD symptoms and associated symptoms.Conclusions:Findings provide support for the psychometric properties of the PTCI and the conceptualization of Sexton’s four-factor and Foa’s three-factor models of PTCI among individuals diagnosed with SMI (Foa et al., 1999).
The unique role of bilingualism among cognitive reserve-enhancing factors
Authors: Gallo Federico , Abutalebi Jubin 
Published: May 2023

AbstractThe umbrella term cognitive reserve-enhancing factors refers to those experiential and lifestyle factors (such as intellectual activities, regular physical exercise, healthy nutrition, educational attainment, etc.) that may help individuals to compensate for age-related neural deterioration, thus enabling them to maintain relatively stable cognitive functioning during senescence. In the last 10 years, mounting evidence has shown that speaking a second language is a powerful cognitive reserve contributor, which could mitigate the consequences of healthy aging and contribute to the delay of dementia onset. In this piece, we argue that bilingualism may play a unique role among the well-known cognitive reserve-enhancing factors, thus contributing to the achievement of successful aging in a distinctive fashion. After reviewing behavioral and neuroimaging evidence for bilingualism-induced protection against healthy and pathological cognitive aging, we discuss theoretical reasons and experimental findings supporting the view that bilingualism should be granted an individual spot among reserve-enhancing life experiences.
Methods used to identify the prevalence of palliative care needs: An integrative review
Authors: Kitreerawutiwong Nithra , Kitreerawutiwong Keerati , Keeratisiroj Orawan , Mekrungrengwong Sunsanee , Thongkhamcharoen Rojanasak 
Published: May 2023

AbstractObjectivesEarly identification of palliative care (PC) needs is crucial to provide appropriate holistic care to patients. The objective of this integrative review is to synthesize the methods used to identify the prevalence of PC needs.MethodsAn integrative review search of the Cumulative Index to Nursing and Allied Health Literature (CINAHL) Plus with full text, ProQuest, Wiley InterScience, ScienceDirect, Scopus, PubMed, and Web of Science with publications from 2010 to 2020 was carried out in English. Empirical studies examining the methods used to determine the prevalence of PC needs were included. The methods of data extraction of the included articles were categorized by data source, study setting, and data collector. Quality appraisal was performed using QualSyst.ResultsOf the 5,410 articles screened, 29 were included in this review. Two articles identified the prevalence of PC needs in a community that was supported by a network of volunteers, while 27 studies considered this at a continent, country, hospital, and/or primary care facility level as represented by physicians, nurses, and researchers.Significance of resultsVarious methods have been used to determine the prevalence of PC needs, and the outcomes are valuable for policymakers in developing PC services when allocating resources at the national and community levels. Future research to identify PC needs across health settings, especially primary care facilities, should consider providing PC across a spectrum of care settings.
Simulated herbicide spray retention of commonly managed invasive emergent aquatic macrophytes
Authors: Haug Erika J , Howell Andrew W , Sperry Benjamin P , Mudge Christopher R , Richardson Robert J , Getsinger Kurt D 
Published: May 2023

AbstractInvasive emergent and floating macrophytes can have detrimental impacts on aquatic ecosystems. Management of these aquatic weeds frequently relies upon foliar application of aquatic herbicides. However, there is inherent variability of overspray (herbicide loss) for foliar applications into waters within and adjacent to the targeted treatment area. The spray retention (tracer dye captured) of four invasive broadleaf emergent species (water hyacinth, alligatorweed, creeping water primrose, and parrotfeather) and two emergent grass-like weeds (cattail and torpedograss) were evaluated. For all species, spray retention was simulated using foliar applications of rhodamine WT (RWT) dye as a herbicide surrogate under controlled mesocosm conditions. Spray retention of the broadleaf species was first evaluated using a CO2-pressurized spray chamber overtop dense vegetation growth or no plants (positive control) at a greenhouse (GH) scale. Broadleaf species and grass-like species were then evaluated in larger outdoor mesocosms (OM). These applications were made using a CO2-pressurized backpack sprayer. Evaluation metrics included species-wise canopy cover and height influence on in-water RWT concentration using image analysis and modeling techniques. Results indicated spray retention was greatest for water hyacinth (GH, 64.7 ± 7.4; OM, 76.1 ± 3.8). Spray retention values were similar among the three sprawling marginal species alligatorweed (GH, 37.5 ± 4.5; OM, 42 ± 5.7), creeping water primrose (GH, 54.9 ± 7.2; OM, 52.7 ± 5.7), and parrotfeather (GH, 48.2 ± 2.3; OM, 47.2 ± 3.5). Canopy cover and height were strongly correlated with spray retention for broadleaf species and less strongly correlated for grass-like species. Although torpedograss and cattail were similar in percent foliar coverage, they differed in percent spray retention (OM, 8.5± 2.3 and 28.9 ±4.1, respectively). The upright leaf architecture of the grass-like species likely influenced the lower spray retention values in comparison to the broadleaf species.
An Observational Constraint of VOC Emissions for Air Quality Modeling Study in the Pearl River Delta Region
Authors: Zhou Beining , Guo Hai , Zeren Yangzong , Wang Yu , Lyu Xiaopu , Wang Boguang , Wang Hongli 
Published: May 2023

AbstractVolatile organic compounds (VOCs) have crucial influences on atmospheric chemistry. Accurate quantification of the VOC emissions is critical for air pollution research, especially when applying to air quality models. However, current bottom‐up emission inventories have biases, making observational constraints of VOC emissions necessary. We conducted concurrent VOC measurements in the Pearl River Delta (PRD) region during the summer of 2018 and found large discrepancies in the spatiotemporal variations of VOCs between observations and model simulations when using the priori VOC emission inventory (Multi‐resolution Emission Inventory for China). The normalized biases of total VOC concentrations ranged from −55% to 85% across the PRD cities in the study period. To improve the simulations, we constrained the anthropogenic VOC emissions based on their measured concentrations. The observation‐constrained VOC emissions showed clear diurnal variations and resolved the spatially‐concentrated priori emissions by reducing the high emissions by 15%–36% in the central PRD cities while elevating the sparse emissions in other cities. After employing the observation‐constrained VOC emissions, the model better reproduced the spatiotemporal variations of VOCs in the PRD region, alleviating the biases to −13%–13%. Furthermore, simulations of peak ozone (O3) concentrations were amended to reduce the mean normalized bias by 5%–12% on high O3 days. Our work has effectively combined VOC field measurements with air quality modeling to achieve better simulations of VOCs and O3. Besides, the observational‐constrained emissions are flexible for studying short‐term emission changes and their subsequent impacts on air quality.
Nitrogen Isotope Record From a Mid‐oceanic Paleo‐Atoll Limestone to Constrain the Redox State of the Panthalassa Ocean in the Capitanian (Late Guadalupian, Permian)
Authors: Saitoh Masafumi , Nishizawa Manabu , Ozaki Kazumi , Ikeda Masayuki , Ueno Yuichiro , Takai Ken , Isozaki Yukio 
Published: May 2023

AbstractThe Capitanian stage is characterized by marine anoxia possibly related to the extinction, although the global redox structure of the Capitanian ocean has not been constrained. We newly report a nitrogen isotope (δ15N) record from a paleo‐atoll limestone at the top of a mid‐Panthalassan seamount to constrain the spatial extent and duration of the Capitanian marine anoxia. The δ15N value of limestone after acid treatment is substantially high for ∼5‐Myr up to +28‰, the highest through the Phanerozoic oceans, suggesting that the nitrogen source (nitrate) was substantially enriched in 15N via denitrification within subsurface oxygen‐deficient zones (ODZs; O2 < 5 µM). Numerical modeling of nitrogen isotope dynamics in the upwelling system along the seamount suggests that the possible minimum δ15N value of a global deep‐oceanic nitrate reservoir was ca. +9‰ in the Capitanian (∼4‰ higher than at the present). Furthermore, a redox‐dependent nitrogen isotope mass balance model constrained the global redox structure of the Capitanian superocean. Substantially reducing conditions (O2 ≤ 20 µM) prevailed at intermediate water depths (100–1,000 m), in association with expanded ODZs with anoxic/euxinic cores along continental margins (≥ ∼0.4% of global ocean volume), while the deep‐ocean remained to be more oxidizing (O2 ≤ 60 µM). The enhanced open‐ocean productivity associated with the low sea‐level and high nutrient flux to the ocean resulted in the global ocean deoxygenation during the cooling stage. Our model is consistent with previous geologic observations and with a possible link between the long‐term (∼5‐Myr) development of marine dysoxia and the extinction.
Cyclic Correlation‐Based Blind SNR Estimation for Cyclic Prefix‐Less OFDM System
Authors: Zhang Liyu , Li Youming , Shi Shoudong , Qi Qinke , Ye Yanhua 
Published: May 2023

AbstractThis paper tackles the problem of the signal‐to‐noise ratio estimation for cyclic prefix (CP)‐Less orthogonal frequency division multiplexing (OFDM) system in the presence of Gaussian noise over multipath fading channels. First, we introduce the cyclic correlation of the CP‐Less OFDM signal with CP, and analyze the cyclic correlations for Gaussian noise and received signal. Second, we isolate the Gaussian noise power from the signal power. Finally, we obtain the close form expression of SNR estimation by using cyclic correlations. Computer simulation results verify the effectiveness of the proposed method.
Permafrost microbial communities and functional genes are structured by latitudinal and soil geochemical gradients
Authors: Waldrop Mark P , Chabot Christopher L , Liebner Susanne , Holm Stine , Snyder Michael W , Dillon Megan , Dudgeon Steven R , Douglas Thomas A , Leewis Mary-Cathrine , Walter Anthony Katey M , McFarland Jack W , Arp Christopher D , Bondurant Allen C , Taş Neslihan , Mackelprang Rachel 
Published: May 2023

Abstract
Permafrost underlies approximately one quarter of Northern Hemisphere terrestrial surfaces and contains 25–50% of the global soil carbon (C) pool. Permafrost soils and the C stocks within are vulnerable to ongoing and future projected climate warming. The biogeography of microbial communities inhabiting permafrost has not been examined beyond a small number of sites focused on local-scale variation. Permafrost is different from other soils. Perennially frozen conditions in permafrost dictate that microbial communities do not turn over quickly, thus possibly providing strong linkages to past environments. Thus, the factors structuring the composition and function of microbial communities may differ from patterns observed in other terrestrial environments. Here, we analyzed 133 permafrost metagenomes from North America, Europe, and Asia. Permafrost biodiversity and taxonomic distribution varied in relation to pH, latitude and soil depth. The distribution of genes differed by latitude, soil depth, age, and pH. Genes that were the most highly variable across all sites were associated with energy metabolism and C-assimilation. Specifically, methanogenesis, fermentation, nitrate reduction, and replenishment of citric acid cycle intermediates. This suggests that adaptations to energy acquisition and substrate availability are among some of the strongest selective pressures shaping permafrost microbial communities. The spatial variation in metabolic potential has primed communities for specific biogeochemical processes as soils thaw due to climate change, which could cause regional- to global- scale variation in C and nitrogen processing and greenhouse gas emissions.
A non-randomized risk-adjusted comparison of lenalidomide + R-CHOP versus R-CHOP for MYC-rearranged DLBCL patients
Authors: de Jonge A. Vera , van Werkhoven Erik , Dinmohamed Avinash G. , Nijland Marcel , Zwinderman Aeilko H. , Bossuyt Patrick M. , Veldhuis Martine S. , Rutten Emma G. G. M. , Mous Rogier , Vermaat Joost S. P. , Sandberg Yorick , de Jongh Eva , Bilgin Yavuz M. , Boersma Rinske , Koene Harry , Kersten Marie José , de Jong Daphne , Chamuleau Martine E. D. 
Published: May 2023

AbstractPatients with MYC rearranged (MYC-R) diffuse large B-cell lymphoma (DLBCL) have a poor prognosis. Previously, we demonstrated in a single-arm phase II trial (HOVON-130) that addition of lenalidomide to R-CHOP (R2CHOP) is well-tolerated and yields similar complete metabolic remission rates as more intensive chemotherapy regimens in literature. In parallel with this single-arm interventional trial, a prospective observational screening cohort (HOVON-900) was open in which we identified all newly diagnosed MYC-R DLBCL patients in the Netherlands. Eligible patients from the observational cohort that were not included in the interventional trial served as control group in the present risk-adjusted comparison. R2CHOP treated patients from the interventional trial (n = 77) were younger than patients in the R-CHOP control cohort (n = 56) (median age 63 versus 70 years, p = 0.018) and they were more likely to have a lower WHO performance score (p = 0.013). We adjusted for differences at baseline using 1:1 matching, multivariable analysis, and weighting using the propensity score to reduce treatment-selection bias. These analyses consistently showed improved outcome after R2CHOP with HRs of 0.53, 0.51, and 0.59, respectively, for OS, and 0.53, 0.59, and 0.60 for PFS. Thus, this non-randomized risk-adjusted comparison supports R2CHOP as an additional treatment option for MYC-R DLBCL patients.
Long COVID risk and pre-COVID vaccination in an EHR-based cohort study from the RECOVER program
Authors: Brannock M. Daniel , Chew Robert F. , Preiss Alexander J. , Hadley Emily C. , Redfield Signe , McMurry Julie A. , Leese Peter J. , Girvin Andrew T. , Crosskey Miles , Zhou Andrea G. , Moffitt Richard A. , Funk Michele Jonsson , Pfaff Emily R. , Haendel Melissa A. , Chute Christopher G. ,   N3C, Stürmer Til , Loomba Johanna J. , Koraishy Farrukh M. ,   RECOVER Consortia, Divers Jasmin , Thorpe Lorna E. , Horwitz Leora , Katz Stuart 
Published: May 2023

AbstractLong COVID, or complications arising from COVID-19 weeks after infection, has become a central concern for public health experts. The United States National Institutes of Health founded the RECOVER initiative to better understand long COVID. We used electronic health records available through the National COVID Cohort Collaborative to characterize the association between SARS-CoV-2 vaccination and long COVID diagnosis. Among patients with a COVID-19 infection between August 1, 2021 and January 31, 2022, we defined two cohorts using distinct definitions of long COVID—a clinical diagnosis (n = 47,404) or a previously described computational phenotype (n = 198,514)—to compare unvaccinated individuals to those with a complete vaccine series prior to infection. Evidence of long COVID was monitored through June or July of 2022, depending on patients’ data availability. We found that vaccination was consistently associated with lower odds and rates of long COVID clinical diagnosis and high-confidence computationally derived diagnosis after adjusting for sex, demographics, and medical history.
Dasatinib overcomes glucocorticoid resistance in B-cell acute lymphoblastic leukemia
Authors: Sarno Jolanda , Domizi Pablo , Liu Yuxuan , Merchant Milton , Pedersen Christina Bligaard , Jedoui Dorra , Jager Astraea , Nolan Garry P. , Gaipa Giuseppe , Bendall Sean C. , Bava Felice-Alessio , Davis Kara L. 
Published: May 2023

AbstractResistance to glucocorticoids (GC) is associated with an increased risk of relapse in B-cell progenitor acute lymphoblastic leukemia (BCP-ALL). Performing transcriptomic and single-cell proteomic studies in healthy B-cell progenitors, we herein identify coordination between the glucocorticoid receptor pathway with B-cell developmental pathways. Healthy pro-B cells most highly express the glucocorticoid receptor, and this developmental expression is conserved in primary BCP-ALL cells from patients at diagnosis and relapse. In-vitro and in vivo glucocorticoid treatment of primary BCP-ALL cells demonstrate that the interplay between B-cell development and the glucocorticoid pathways is crucial for GC resistance in leukemic cells. Gene set enrichment analysis in BCP-ALL cell lines surviving GC treatment show enrichment of B cell receptor signaling pathways. In addition, primary BCP-ALL cells surviving GC treatment in vitro and in vivo demonstrate a late pre-B cell phenotype with activation of PI3K/mTOR and CREB signaling. Dasatinib, a multi-kinase inhibitor, most effectively targets this active signaling in GC-resistant cells, and when combined with glucocorticoids, results in increased cell death in vitro and decreased leukemic burden and prolonged survival in an in vivo xenograft model. Targeting the active signaling through the addition of dasatinib may represent a therapeutic approach to overcome GC resistance in BCP-ALL.
Determining the gas-phase structures of α-helical peptides from shape, microsolvation, and intramolecular distance data
Authors: Wu Ri , Metternich Jonas B. , Kamenik Anna S. , Tiwari Prince , Harrison Julian A. , Kessen Dennis , Akay Hasan , Benzenberg Lukas R. , Chan T.-W. Dominic , Riniker Sereina , Zenobi Renato 
Published: May 2023

AbstractMass spectrometry is a powerful technique for the structural and functional characterization of biomolecules. However, it remains challenging to accurately gauge the gas-phase structure of biomolecular ions and assess to what extent native-like structures are maintained. Here we propose a synergistic approach which utilizes Förster resonance energy transfer and two types of ion mobility spectrometry (i.e., traveling wave and differential) to provide multiple constraints (i.e., shape and intramolecular distance) for structure-refinement of gas-phase ions. We add microsolvation calculations to assess the interaction sites and energies between the biomolecular ions and gaseous additives. This combined strategy is employed to distinguish conformers and understand the gas-phase structures of two isomeric α-helical peptides that might differ in helicity. Our work allows more stringent structural characterization of biologically relevant molecules (e.g., peptide drugs) and large biomolecular ions than using only a single structural methodology in the gas phase.
Asymmetric α-allylic allenylation of β-ketocarbonyls and aldehydes by synergistic Pd/chiral primary amine catalysis
Authors: You Chang , Shi Mingying , Mi Xueling , Luo Sanzhong 
Published: May 2023

AbstractWe herein describe an asymmetricα-allylic allenylation ofβ-ketocarbonyls and aldehydes with 1,3-enynes. A synergistic chiral primary amine/Pd catalyst was identified to facilitate the utilization of 1,3-enynes as atom-economic and achiral allene precursors. The synergistic catalysis enables the construction of all-carbon quaternary centers-tethered allenes bearing non-adjacent 1,3-axial central stereogenic centers in high level of diastereo- and enantio-selectivity. By switching the configurations of ligands and aminocatalysts, diastereodivergence can be achieved and any of the four diastereoisomers can be accessed in high diastereo- and enantio- selectivity.
Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes
Authors: Maitra Malosree , Mitsuhashi Haruka , Rahimian Reza , Chawla Anjali , Yang Jennie , Fiori Laura M. , Davoli Maria Antonietta , Perlman Kelly , Aouabed Zahia , Mash Deborah C. , Suderman Matthew , Mechawar Naguib , Turecki Gustavo , Nagy Corina 
Published: May 2023

AbstractMajor depressive disorder (MDD) is a common, heterogenous, and potentially serious psychiatric illness. Diverse brain cell types have been implicated in MDD etiology. Significant sexual differences exist in MDD clinical presentation and outcome, and recent evidence suggests different molecular bases for male and female MDD. We evaluated over 160,000 nuclei from 71 female and male donors, leveraging new and pre-existing single-nucleus RNA-sequencing data from the dorsolateral prefrontal cortex. Cell type specific transcriptome-wide threshold-free MDD-associated gene expression patterns were similar between the sexes, but significant differentially expressed genes (DEGs) diverged. Among 7 broad cell types and 41 clusters evaluated, microglia and parvalbumin interneurons contributed the most DEGs in females, while deep layer excitatory neurons, astrocytes, and oligodendrocyte precursors were the major contributors in males. Further, the Mic1 cluster with 38% of female DEGs and the ExN10_L46 cluster with 53% of male DEGs, stood out in the meta-analysis of both sexes.