bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights into research on myocardial ischemia/reperfusion injury from 2012 to 2021: a bibliometric analysis
Authors: Bai Ming , Zhang Jingjing , Chen De , Lu Mengying , Li Junfen , Zhang Zheng , Niu Xiaowei 
Published: January 2023

Abstract
Background
Numerous studies on myocardial ischemia/reperfusion (MI/R) injury have been undertaken in recent years. Hotspots and developmental trends in MI/R research are being rapidly updated. However, there has been no bibliometric analysis that systematically evaluates existing literature on MI/R injury. Our study explores developments in MI/R research over the past decade, and provides a reference for future research.

Materials and methods
Both experimental and clinical publications on MI/R injury from 2012 to 2021 were retrieved from the Web of Science Core Collection database. The CiteSpace and VOSviewer tools were used to perform a bibliometric analysis.

Results
A total of 8419 papers were analyzed. The number of annual publications demonstrated an overall upward trend, rising from 629 publications in 2012 to 1024 publications in 2021. China, the USA, Germany, England, and Italy were the top five contributors to MI/R studies. The Fourth Military Medical University in China contributed the most publications (188, 2.23%), while the University College London in England cooperated the most with relevant research institutions. Derek J Hausenloy (University College London), Derek M Yellon (University College London), and Gerd Heusch (University of Essen Medical School) were the top three most active and influential scholars according to the H-index. Among the top 10 journals with the most publications, Basic Research in Cardiology had the highest impact factors. The top three co-cited journals were Circulation, Circulation Research, and Cardiovascular Research. According to a co-cited reference analysis, MI/R research can be divided across 10 major subfields of mitophagy, cardioprotection, inflammation, remote ischemic preconditioning, long non-coding RNA, melatonin, postconditioning, mitochondria, microvascular obstruction, and ferroptosis. After 2018, the keywords with strongest citation bursts included extracellular vesicles, long non-coding RNA, cell proliferation, microRNA, mitochondrial quality control, mitophagy, biomarker, and mitochondrial biogenesis.

Conclusions
The present study reveals the influential authors, cooperating institutions, and main research foci in the field of MI/R injury in the past decade. The latest hotspots are a more in-depth insight into the molecular mechanisms underlying MI/R injury, such as mitochondrial quality control, non-coding RNAs, cell proliferation, and extracellular vesicles.
Psychological distress in adolescents: prevalence and its relation to high-risk behaviors among secondary school students in Mbarara Municipality, Uganda
Authors: Anyanwu Michael U. 
Published: January 2023

Abstract
Background
Psychological distress among adolescents negatively affects their academic performance, relationships with family and friends, and ability to participate fully in the community. Stressful life events in low-income countries and risk-taking behavior of adolescents have raised concerns regarding the impact of psychological distress among adolescents. Therefore, the present study estimated the prevalence of psychological distress and examined the high-risk behaviors associated with psychological distress among Ugandan adolescents.

Methods
A community based cross-sectional study was conducted among secondary school students in Mbarara Municipality, Uganda. Multistage cluster sampling was used to recruit 921 adolescents from 12 schools. Psychological distress was assessed using the 10-item Kessler Psychological Distress Scale (K10). Logistic regression was used with p-value estimating regression coefficient and 95% confidence interval for odds ratio and adjusted odds ratio (AOR).

Results
The prevalence of psychological distress using the K10 was 57%. Logistic regression analyses showed that risky sexual behavior [AOR = 1.52; 95% confidence interval (CI) 1.02–2.28], substance use (AOR = 2.06; 95% CI 1.49–2.84) were associated with psychological distress. Students in mixed schools (comprising both sexes) (AOR = 1.94; 95% CI 1.19–3.15) and adolescents with chronic illness (AOR = 1.68; 95% CI 1.18–2.38) were more likely to report psychological distress.

Conclusion
The prevalence of psychological distress among school-going adolescents is high. Risky sexual behavior, substance use as well as chronic illness were associated with psychological distress. In addition, the type of school was significantly associated with psychological distress. The findings suggest the need for policy makers and stakeholders in health and education sectors to institute measures that will address mental health issues among adolescents.
Small grains from Ryugu: handling and analysis pipeline for infrared synchrotron microspectroscopy
Authors: Rubino Stefano , Dionnet Zélia , Aléon-Toppani Alice , Brunetto Rosario , Nakamura Tomoki , Baklouti Donia , Djouadi Zahia , Lantz Cateline , Mivumbi Obadias , Borondics Ferenc , Lefrançois Stephane , Sandt Christophe , Capitani Francesco , Héripré Eva , Troadec David , Matsumoto Megumi , Amano Kana , Morita Tomoyo , Yurimoto Hisayoshi , Noguchi Takaaki , Okazaki Ryuji , Yabuta Hikaru , Naraoka Hiroshi , Sakamoto Kanako , Tachibana Shogo , Watanabe Seiichiro , Tsuda Yuichi ,   the Hayabusa2-initial-analysis team
Published: January 2023

AbstractSample-return missions allow the study of materials collected directly from celestial bodies, unbiased by atmospheric entry effects and/or terrestrial alteration and contamination phenomena, using state-of-the-art techniques which are available only in a laboratory environment—but only if the collected material stays pristine. The scarcity of outer-space unaltered material recovered until now makes this material extremely precious for the potential scientific insight it can bring. To maximize the scientific output of current and future sample-return missions, the scientific community needs to plan for ways of storing, handling, and measuring this precious material while preserving their pristine state for as long as the ‘invasiveness’ of measurements allows. In July 2021, as part of the Hayabusa2 (JAXA) “Stone” preliminary examination team, we received several microscopic particles from the asteroid Ryugu, with the goal of performing IR hyper-spectral imaging and IR micro-tomography studies. Here, we describe the sample transfer, handling methods and analytical pipeline we implemented to study this very precious material while minimizing and surveilling their alteration history on Earth.
Graphical Abstract
Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatment
Authors: Zhuang Zheng , Zhong Xueqing , Li Qinghua , Liu Tian , Yang Qing , Lin Guo-Qiang , He Qing-Li , Zhao Qunfei , Liu Wen 
Published: January 2023

AbstractPhyscion is an anthraquinone compound observed dominantly in medicinal herbs. This anthraquinone possesses a variety of pharmaceutically important activities and has been developed to be a widely used antifungal biopesticide. Herein, we report on the effective preparation of 3R-torosachrysone (4), a tetrahydroanthracene precursor of physcion, in Aspergillus oryzae NSAR1 by heterologous expression of related genes mined from the phlegmacins-producing ascomycete Talaromyces sp. F08Z-0631. Conditions for converting 4 into physcion were studied and optimized, leading to the development of a concise approach for extracting high-purity physcion from the alkali-treated fermentation broth of the 4-producing A. oryzae strain.
Graphical Abstract
Dealing with dry waste disposal issues associated with 177mLu impurities: a long-term challenge for nuclear medicine departments
Authors: Prevot Sylviane , Dygaï-Cochet Inna , Riedinger Jean-Marc , Vrigneaud Jean-Marc , Quermonne Myriam , Gallet Matthieu , Cochet Alexandre 
Published: January 2023

Abstract
Purpose
A strategy for management of radioactive waste associated with 177Lu-dotatate (Lutathera®) treatments was established in our institution, based on predicted storage times of 3–5 years extrapolated from the results of a 2-year measurement study. The aim of this work was to validate this strategy by identifying contaminants and confirming disposal based on the clearance level twice-the-background was within expected time frames.

Methods
We conducted a prospective series of measurements of radioactive waste associated with the first 65 treatments administered. Sequential measurements of the first 45 vials used were performed on a dose calibrator to identify contaminants. Exposure rates in contact were monitored with a dose ratemeter on a 6-monthly basis for all waste stored: 46 empty vials, 19 vials partially used and 61 biohazard containers.

Results
Initial median activity of the first vials used was 118 MBq [4–4188 MBq]. For each vial, the decay curve of activity obtained was adjusted to a bi-exponential model. The major component, representing 99.7% of the activity, has a median half-life of 6.6 days [5.7–7.2 days] corresponding to 177Lu. The second, representing only 0.3% of the activity and having a median half-life of 152 days [104–205 days] corresponding to 177mLu, determines necessary storage times. Partially used vials can be disposed of after 5 years, other waste after 3 years. Compliance with the regulatory clearance level is achieved within expected time frames.

Conclusion
Although only present as traces, 177mLu associated with the direct production route results in major radioactive waste disposal issues for hospitals. Availability of radiopharmaceuticals without impurities appears to be crucial for an expanding use of targeted radionuclide therapy.
GIS based urban social vulnerability assessment for liquefaction susceptible areas: a case study for greater Chennai, India
Authors: Manoharan Saravana Ganesh , Ganapathy Ganapathy Pattukandan 
Published: January 2023

Abstract
Background
The areas prone to geological hazards such as liquefaction need special attention with respect to social vulnerability. Though liquefaction by itself may not result in damage, it may trigger a series of ground failures such as ground oscillation, lateral spread, loss of bearing strength, etc., which cause heavy damage. Globally, during the past few decades liquefaction hazard analysis has become one of the important criteria in seismic risk analysis and mitigation management, especially for urban areas. Greater Chennai is one of the million-plus population cities in India. The city also felt earthquakes/tremors in the past history.

Method
The present study aims to assess the social vulnerability of the population density of the Greater Chennai area due to liquefaction susceptibility using GIS technology. The liquefaction susceptibility map (hazard) for the Greater Chennai was prepared by integration of geological and geomorphological parameters and analyzed over socioeconomic parameters (exposure) using an integration of GIS and AHP.

Results
The result showed that around 53% of Greater Chennai’s households and population are very much exposed to liquefaction hazard.

Conclusions
This study can be used as a base level study for decision-making during land use planning as well as disaster mitigation planning.
Effects of using the first principles of instruction in a content and language integrated learning class
Authors: Hao Hao , Susono Hitoshi , Geng Xuewang , Chen Li , Yamada Masanori 
Published: January 2023

AbstractThe aim of this study was to examine the effects of Content and Language Integrated Learning (CLIL) designed according to the First Principles of Instruction (FPI). A 15-h Japanese CLIL course was implemented. A total of 16 university students attended the course and data were collected from multiple sources, including learning tests, questionnaire feedback, and dialogues in group discussions, were collected and examined. Analysis showed that students’ learning outcomes, including basic Japanese proficiency, intercultural communication content, and writing skills, were statistically significantly improved. Students had a high level of awareness of the elements of FPI designed in the course. In addition, all the FPI elements had a positive impact on basic Japanese proficiency except for the application element: the problem-centered, application, and integration elements positively impacted intercultural communication content and writing skills. The results show that students displayed individual differences in using the worksheet to summarize their writing ideas. Students spent most of the time in the group discussions in their native language. Even when Japanese was used, individual Japanese words were used rather than whole sentences in most cases. The results of the quantitative and qualitative analyses showed that the use of problem-centered theory FPI had a positive impact on the design of the CLIL. However, attention is needed to students’ individual differences and the guidance of students in applying basic language knowledge in problem-centered learning activities. Finally, it notes points that should be considered when designing CLIL in the future.
The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin
Authors: Lee Ji Hae , Kweon HaeYong , Oh Ji-Hyeon , Kim Seong-Gon 
Published: January 2023

Abstract
Background
Silk sericin is an active ingredient in bone grafts. However, the optimal scaffold for silk sericin has yet to be identified.

Method
A critical-sized bone defect model in rat calvaria was used to evaluate bone regeneration. Silk sericin from Yeonnokjam, Bombyx mori, was incorporated into gelatin (group G, n = 6) and collagen (group C, n = 6). Bone regeneration was evaluated using micro-computed tomography (mCT) and histology.

Results
Group C showed a larger bone volume than group G in the mCT analysis (P = 0.001). Histological analysis showed a larger area of bony defects in group G than in group C. The bone regeneration area in group C was significantly larger than that in group G (P = 0.003).

Conclusion
Compared with gelatin, collagen shows better bone regeneration in silk sericin-based bone grafts.
Comparison of image quality of two versions of deep-learning image reconstruction algorithm on a rapid kV-switching CT: a phantom study
Authors: Dabli Djamel , Loisy Maeliss , Frandon Julien , de Oliveira Fabien , Meerun Azhar Mohamad , Guiu Boris , Beregi Jean-Paul , Greffier Joël 
Published: January 2023

Abstract
Background
To assess the impact of the new version of a deep learning (DL) spectral reconstruction on image quality of virtual monoenergetic images (VMIs) for contrast-enhanced abdominal computed tomography in the rapid kV-switching platform.

Methods
Two phantoms were scanned with a rapid kV-switching CT using abdomen-pelvic CT examination parameters at dose of 12.6 mGy. Images were reconstructed using two versions of DL spectral reconstruction algorithms (DLSR V1 and V2) for three reconstruction levels. The noise power spectrum (NSP) and task-based transfer function at 50% (TTF50) were computed at 40/50/60/70 keV. A detectability index (d') was calculated for enhanced lesions at low iodine concentrations: 2, 1, and 0.5 mg/mL.

Results
The noise magnitude was significantly lower with DLSR V2 compared to DLSR V1 for energy levels between 40 and 60 keV by -36.5% ± 1.4% (mean ± standard deviation) for the standard level. The average NPS frequencies increased significantly with DLSR V2 by 23.7% ± 4.2% for the standard level. The highest difference in TTF50 was observed at the mild level with a significant increase of 61.7% ± 11.8% over 40−60 keV energy with DLSR V2. The d' values were significantly higher for DLSR V2 versus DLSR V1.

Conclusions
The DLSR V2 improves image quality and detectability of low iodine concentrations in VMIs compared to DLSR V1. This suggests a great potential of DLSR V2 to reduce iodined contrast doses.
Sacropelvic fixation
Authors: Youssef Essam M. 
Published: January 2023

AbstractThe sacropelvis is not only an anatomically complex region but also a biomechanically unique zone transferring axial weights via the transitional lumbosacral junction and the pelvic girdle to the lower appendicular skeleton. When the sacral instrumentation alone is insufficient to achieve stability and solid arthrodesis across the lumbosacral junction, as in long-segment fusions, high-grade spondylolisthesis, deformity corrections, complex sacral/lumbosacral injuries, and neoplasms, sacropelvic fixation is indicated. Many modern sacropelvic fixation modalities outperform historical modalities, especially the conventionally open and percutaneous iliac and S2-alar-iliac screw (S2AI) fixation techniques. Novel screw insertion technologies such as navigation and robotics and modern screw designs aim to maximize the accuracy of screw placement and minimize complications. This review addresses the anatomy and biomechanics of the sacropelvic region as well as the indications, evolution, advantages, and disadvantages of various past and contemporary techniques of lumbosacral and sacropelvic fixation.
Forest fire pattern and vulnerability mapping using deep learning in Nepal
Authors: Mishra Bhogendra , Panthi Saroj , Poudel Shobha , Ghimire Bhoj Raj 
Published: January 2023

Abstract
Background
In the last two decades, Nepal has experienced an increase in both forest fire frequency and area, but very little is known about its spatiotemporal dimension. A limited number of studies have researched the extent, timing, causative parameters, and vulnerability factors regarding forest fire in Nepal. Our study analyzed forest fire trends and patterns in Nepal for the last two decades and analyzed forest fire-vulnerability risk based on historical incidents across the country.

Results
We analyzed the spatial and temporal patterns of forest fires and the extent of burned area using the Mann-Kendall trend test and two machine-learning approaches maximum entropy (MaxEnt), and deep neural network (DNN). More than 78% of the forest fire burned area was recorded between March and May. The total burned area has increased over the years since 2001 by 0.6% annually. The forest fire-vulnerability risk obtained from both approaches was categorized into four classes—very high, high, low, and very low.

Conclusions
Although burned area obtained from both models was comparable, the DNN slightly outperformed the MaxEnt model. DNN uses a complex structure of algorithms modeled on the human brain that enables the processing of the complex relationship between input and output dataset, making DNN-based models recommended over MaxEnt. These findings can be very useful for initiating and implementing the most suitable forest management intervention.
Spontaneous cerebrospinal fluid fistula secondary to hyper-pneumatized paranasal sinuses and skull base: two case reports
Authors: Poojary Shweta Raviraj , Kini Divya Vishwanatha , Kapilamoorthy T. R. , Chittaragi Kavitha B. , Gurumurthy Balasubramanian 
Published: January 2023

Abstract
Background
Spontaneous cerebrospinal fluid (CSF) fistulas occur due to various reasons other than well-identified causes such as trauma, neoplasia or infection. Various contributory factors are attributed to formation of spontaneous CSF leaks such as idiopathic intracranial hypertension leading to prominent arachnoid granulations. Further, presence of hyper-pneumatized paranasal sinuses or the skull base weakens the bone and predisposes to development of spontaneous defects and further fistulas. This case report highlights two cases of spontaneous CSF leaks associated with hyper-pneumatized petrous bone and sphenoid sinus.

Case presentation
A 26-year-old female patient with history of right rhinorrhea with imaging evidence of bilateral hyper-pneumatized petrous bones and a bony defect in the right petrous bone on computed tomography (CT). Subsequent CT cisternography demonstrated CSF leak extending into the right pneumatized petrous apex cells, Eustachian tube, middle ear cavity, aditus, antrum and mastoid air cells. Pooling of contrast in the right nasal cavity and ethmoid cells was also seen. A 49-year-old female patient with history of right rhinorrhea with features of hyper-pneumatization of sphenoid bone involving right greater wing of sphenoid bone and bilateral pterygoid process with a bony defect in the right greater wing of sphenoid was demonstrated on CT. Corroborative magnetic resonance imaging (MRI) brain Constructive interference in steady state (CISS) sequence revealed a meningoencephalocele. Additionally, a suspicious focal dehiscence was observed in the right cribriform plate CSF pockets herniating into right ethmoid sinus.

Conclusion
Hyper-pneumatized petrous bone and paranasal sinuses can be attributed as a risk factor for formation of spontaneous CSF leaks.
Rare case of calcified fibrin sheath causing central venous occlusion, mimicking a retained catheter fragment
Authors: Lee Sze Yuen , Arunasalam Yamunadevi , Mohamad Sri Idayu 
Published: January 2023

Abstract
Background
Long-term placements of central venous catheters (CVCs) are known to cause various complications, among which include fibrin sheath formation, causing catheter dysfunction, infection and thrombosis. Post-catheter removal, these sheaths may sometimes be retained in the vein; however, are rarely calcified. When retained sheaths are calcified, they may cause diagnostic confusion on imaging, as they may mimic a retained catheter fragment.

Case presentation
We report a case of a patient with end-stage renal disease and a history of multiple prior CVC insertions presenting with symptoms of central venous occlusion post-revascularization of his stenosed arteriovenous fistula. CT venography revealed a linear tubular hyperdensity within the right brachiocephalic vein and superior vena cava, which at first glance looked like a retained catheter fragment. However, further scrutiny revealed a retained calcified intravascular fibrin sheath as the cause of occlusion.

Conclusions
Awareness of the radiological discriminating features of calcified fibrin sheaths are important to prevent misdiagnosis and unnecessary interventions as these sheaths may mimic retained catheter fragments. Calcified fibrin sheaths should also be considered as a differential diagnosis of radio-opaque intravascular structures or venous calcifications post-CVC removal.
An unusual indication of maxillectomy—a case presentation of sphenoid wing meningioma
Authors: Singh Ishwar , Sharma Raman , Jagetia Anita , Gopal Ashish , Jain Pooja Nakhat 
Published: January 2023

Abstract
Background
Sphenoid wing meningiomas (SWMs) are named because of their site of origin which is in the vicinity of the sphenoid wing. They are further classified into globoid type and en plaque (aka spheno-orbital meningiomas). These tumours are known for their difficult management because of their invasion to various neurovascular structures and bones. Surgical removal of these tumours is challenging. Complete surgical excision of the tumour is not always guaranteed; hence, intentional incomplete removal sometimes is mandatory to reduce postoperative morbidity. The purpose of this case report is to emphasize and describe the unexplored role of total maxillectomy in the excision of the extensive skull base tumours involving the orbit and infratemporal fossa.

Case presentation
In this case report, we are presenting a case of a 50-year-old male diagnosed a case of atypical sphenoid wing meningioma with orbital and paranasal sinus extension who was previously operated on by extracranial approach and presented with the recurrence. Here, we are providing insight and surgical management of this case using total maxillectomy as an approach to access the intracranial approach.

Conclusion
Maxillectomy with orbital exenteration can be used as a successful surgical approach to manage skull base lesions and intracranial tumours without any evident post-op complications.