bluuebunny/crossref_metadata_2025_split huggingface dataset:
Far-infrared polarization of the supernova remnant Cassiopeia A with SOFIA HAWC +
Authors: Rho Jeonghee , Ravi Aravind P , Tram Le Ngoc , Hoang Thiem , Chastenet Jérémy , Millard Matthew , Barlow Michael J , De Looze Ilse , Gomez Haley L , Kirchschlager Florian , Dunne Loretta 
Published: April 2023

ABSTRACT
We present polarization observations of the young supernova remnant (SNR) Cas A using the High-resolution Airborne Wideband Camera-Plus (HAWC +) instrument onboard the Stratospheric Observatory for Infrared Astronomy (SOFIA). The polarization map at 154 $\mu$m reveals dust grains with strong polarization fractions (5–30 per cent), supporting previous measurements made over a smaller region of the remnant at 850 $\mu$m. The 154-$\mu$m emission and the polarization signal is coincident with a region of cold dust observed in the southeastern shell and in the unshocked central ejecta. The highly polarized far-IR emission implies the grains are large (&gt;0.14 $\mu$m) and silicate-dominated. The polarization level varies across the SNR, with an inverse correlation between the polarization degree and the intensity and smaller polarization angle dispersion for brighter SNR emission. Stronger polarization is detected between the bright structures. This may result from a higher collision rate between the gas and dust producing a lower grain alignment efficiency where the gas density is higher. We use the dust emission to provide an estimate of the magnetic field strength in Cas A using the Davis–Chandrasekhar–Fermi method. The high polarization level is direct evidence that grains are highly elongated and strongly aligned with the magnetic field of the SNR. The dust mass from the polarized region is 0.14 ± 0.04 M⊙, a lower limit of the amount of dust present within the ejecta of Cas A. This result strengthens the hypothesis that core-collapse SNe are an important contributor to the dust mass in high redshift galaxies.
Tree-based solvers for adaptive mesh refinement code flash – IV. An X-ray radiation scheme to couple discrete and diffuse X-ray emission sources to the thermochemistry of the interstellar medium
Authors: Gaches Brandt A L , Walch Stefanie , Wünsch Richard , Mackey Jonathan 
Published: April 2023

ABSTRACT
X-ray radiation, in particular radiation between 0.1 and 10 keV, is evident from both point-like sources, such as compact objects and T-Tauri young stellar objects, and extended emission from hot, cooling gas, such as in supernova remnants. The X-ray radiation is absorbed by nearby gas, providing a source of both heating and ionization. While protoplanetary chemistry models now often include X-ray emission from the central young stellar object, simulations of star-forming regions have yet to include X-ray emission coupled to the chemo-dynamical evolution of the gas. We present an extension of the treeray reverse ray trace algorithm implemented in the flash magnetohydrodynamic code which enables the inclusion of X-ray radiation from 0.1 keV &lt; Eγ &lt; 100 keV, dubbed xraythespot. xraythespot allows for the use of an arbitrary number of bins, minimum and maximum energies, and both temperature-independent and temperature-dependent user-defined cross-sections, along with the ability to include both point and extended diffuse emission and is coupled to the thermochemical evolution. We demonstrate the method with several multibin benchmarks testing the radiation transfer solution and coupling to the thermochemistry. Finally, we show two example star formation science cases for this module: X-ray emission from protostellar accretion irradiating an accretion disc and simulations of molecular clouds with active chemistry, radiation pressure, and protostellar radiation feedback from infrared to X-ray radiation.
Galaxy clustering from the bottom up: a streaming model emulator I
Authors: Cuesta-Lazaro Carolina , Nishimichi Takahiro , Kobayashi Yosuke , Ruan Cheng-Zong , Eggemeier Alexander , Miyatake Hironao , Takada Masahiro , Yoshida Naoki , Zarrouk Pauline , Baugh Carlton M , Bose Sownak , Li Baojiu 
Published: April 2023

ABSTRACT
In this series of papers, we present a simulation-based model for the non-linear clustering of galaxies based on separate modelling of clustering in real space and velocity statistics. In the first paper, we present an emulator for the real-space correlation function of galaxies, whereas the emulator of the real-to-redshift space mapping based on velocity statistics is presented in the second paper. Here, we show that a neural network emulator for real-space galaxy clustering trained on data extracted from the dark quest suite of N-body simulations achieves sub-per cent accuracies on scales 1 &lt; r &lt; 30 $h^{-1} \, \mathrm{Mpc}$, and better than 3 per cent on scales r &lt; 1 $h^{-1}\, \mathrm{Mpc}$ in predicting the clustering of dark-matter haloes with number density 10−3.5$(h^{-1}\, \mathrm{Mpc})^{-3}$, close to that of SDSS LOWZ-like galaxies. The halo emulator can be combined with a galaxy–halo connection model to predict the galaxy correlation function through the halo model. We demonstrate that we accurately recover the cosmological and galaxy–halo connection parameters when galaxy clustering depends only on the mass of the galaxies’ host halos. Furthermore, the constraining power in σ8 increases by about a factor of 2 when including scales smaller than 5 $h^{-1} \, \mathrm{Mpc}$. However, when mass is not the only property responsible for galaxy clustering, as observed in hydrodynamical or semi-analytic models of galaxy formation, our emulator gives biased constraints on σ8. This bias disappears when small scales (r &lt; 10 $h^{-1}\, \mathrm{Mpc}$) are excluded from the analysis. This shows that a vanilla halo model could introduce biases into the analysis of future data sets.
Multi-epoch hard X-ray view of Compton-thick AGN Circinus Galaxy
Authors: Kayal Abhijit , Singh Veeresh , Ricci Claudio , Mithun N P S , Vadawale Santosh , Dewangan Gulab , Gandhi Poshak 
Published: April 2023

ABSTRACT
The circumnuclear material around active galactic nuclei (AGNs) is one of the essential components of the obscuration-based unification model. However, our understanding of the circumnuclear material in terms of its geometrical shape, structure, and its dependence on accretion rate is still debated. In this paper, we present the multi-epoch broad-band X-ray spectral modelling of a nearby Compton-thick AGN in Circinus galaxy. We utilize all the available hard X-ray (&gt;10 keV) observations taken from different telescopes, i.e. BeppoSAX, Suzaku, NuSTAR, and AstroSat, at 10 different epochs across 22 yr from 1998 to 2020. The 3.0–79 keV broad-band X-ray spectral modelling using physically motivated models, namely MYTorus, borus02, and uxclumpy, infers the presence of a torus with a low covering factor of 0.28, an inclination angle of 77°–81° and Compton-thick line-of-sight column densities (NH,LOS = 4.13–9.26 × 1024 cm−2) in all the epochs. The joint multi-epoch spectral modelling suggests that the overall structure of the torus is likely to remain unchanged. However, we find tentative evidence for the variable line-of-sight column density on time-scales ranging from 1 d to 1 week to a few years, suggesting a clumpy circumnuclear material located at subparsec to tens of parsec scales.
Young but fading radio sources: searching for remnants among compact steep-spectrum radio sources
Authors: Orienti M , Murgia M , Dallacasa D , Migliori G , D’Ammando F 
Published: April 2023

ABSTRACT
The incidence of young but fading radio sources provides important information on the life cycle of radio emission in radio-loud active galactic nuclei. Despite its importance for constraining the models of radio source evolution, there are no systematic studies of remnants in complete samples of young radio sources. We report results of the study of 18 compact steep-spectrum (CSS) radio sources, selected from the statistically complete B3-VLA (Very Large Array) CSS sample, characterized by a steep optically thin spectrum (α ≥ 1.0) and no core detection in earlier studies. Our deep multifrequency VLA, pc-scale Very Long Baseline Array, and enhanced Multi Element Remotely Linked Interferometer Network (e-MERLIN) observations allowed us to locate the core component in 10 objects. In three CSS sources, there is no clear evidence of present-time active regions, suggesting that they are likely in a remnant phase. Among sources with core detection, we find three objects that have no clear active regions (hotspots) at the edges of the radio structure, suggesting that the radio emission may have just restarted. Our results support a power-law distribution of the source ages, although the poor statistics prevents us from setting solid constraints on the percentage of remnants and restarted sources in subpopulations of radio sources.
Integral Field Spectroscopy of the cometary starburst galaxy NGC 4861
Authors: Roche Nathan , Vílchez José M , Iglesias-Páramo Jorge , Papaderos Polychronis , Sánchez Sebastian F , Kehrig Carolina , Duarte Puertas Salvador 
Published: April 2023

ABSTRACT
Using the PMAS Integral Field Unit on the Calar Alto 3.5 m telescope, we observed the southern component (Markarian 59) of the ‘cometary’ starburst galaxy NGC 4861. Mrk 59 is centred on a giant nebula and concentration of stars 1 kpc in diameter. Strong $\rm H\,\alpha$ emission points to a star-formation rate (SFR) at least 0.47 $\rm M_{\odot }\, yr^{-1}$. Mrk 59 has a very high [O iii] $\rm \lambda 5007/H\,\beta$ ratio, reaching 7.35 in the central nebula, with a second peak at a star-forming hotspot further north. Fast outflows are not detected but nebular motion and galaxy rotation produce relative velocities up to 40 km $\rm s^{-1}$. Spectral analysis of different regions with ‘Fitting Analysis using Differential evolution Optimization’ (FADO) finds that the stars in the central and ‘spur’ nebulae are very young, $\rm \le 125~Myr$ with a large $\rm \lt 10~Myr$ contribution. Older stars ($\rm \sim 1~Gyr$) make up the northern disk component, while the other regions show mixtures of 1 Gyr age with very young stars. This and the high specific SFR $\rm \sim 3.5~Gyr^{-1}$ imply a bimodal star formation history, with Mrk 59 formed in ongoing starbursts fuelled by a huge gas inflow, turning the galaxy into an asymmetric ‘green pea’ or blue compact dwarf. We map the He ii λ4686 emission, and identify a broad component from the central nebula, consistent with the emission of ∼300 Wolf–Rayet stars. About a third of the He ii λ4686 flux is a narrow line emitted from a more extended area covering the central and spur nebulae, and may have a different origin.
Inner edges of planetesimal belts: collisionally eroded or truncated?
Authors: Imaz Blanco Amaia , Marino Sebastian , Matrà Luca , Booth Mark , Carpenter John , Faramaz Virginie , Henning Thomas , Hughes A Meredith , Kennedy Grant M , Pérez Sebastián , Ricci Luca , Wyatt Mark C 
Published: April 2023

ABSTRACT
The radial structure of debris discs can encode important information about their dynamical and collisional history. In this paper, we present a three-phase analytical model to analyse the collisional evolution of solids in debris discs, focusing on their joint radial and temporal dependence. Consistent with previous models, we find that as the largest planetesimals reach collisional equilibrium in the inner regions, the surface density of dust and solids becomes proportional to ∼r2 within a certain critical radius. We present simple equations to estimate the critical radius and surface density of dust as a function of the maximum planetesimal size and initial surface density in solids (and vice versa). We apply this model to Atacama Large Millimeter/submillimeter Array observations of seven wide debris discs. We use both parametric and non-parametric modelling to test if their inner edges are shallow and consistent with collisional evolution. We find that four out of seven have inner edges consistent with collisional evolution. Three of these would require small maximum planetesimal sizes below 10 km, with HR 8799’s disc potentially lacking solids larger than a few centimetres. The remaining systems have inner edges that are much sharper, which requires maximum planetesimal sizes ≳ 10 km. Their sharp inner edges suggest they could have been truncated by planets, which JWST could detect. In the context of our model, we find that the seven discs require surface densities below a Minimum Mass Solar Nebula, avoiding the so-called disc mass problem. Finally, during the modelling of HD 107146 we discover that its wide gap is split into two narrower ones, which could be due to two low-mass planets formed within the disc.
Three-body recombination of hydrogen in the early Universe
Authors: Flower D R 
Published: April 2023

ABSTRACT
It has been suggested recently that three-body recombination of two protons and an electron might be significant in the formation of atomic hydrogen in the early Universe. We demonstrate that this process is completely negligible in the primordial plasma and that the value of the redshift, at which the transition from ionized to atomic hydrogen occurs, is determined by an equilibrium between the rates of two-body radiative recombination of a proton and an electron and its inverse, namely photoionization of atomic hydrogen.
The monomeric archaeal primase from Nanoarchaeum equitans harbours the features of heterodimeric archaeoeukaryotic primases and primes sequence-specifically
Authors: Schneider Andy , Bergsch Jan , Lipps Georg 
Published: April 2023

Abstract
The marine thermophilic archaeon Nanoarchaeum equitans possesses a monomeric primase encompassing the conserved domains of the small catalytic and the large regulatory subunits of archaeoeukaryotic heterodimeric primases in one protein chain. The recombinant protein primes on templates containing a triplet with a central thymidine, thus displaying a pronounced sequence specificity typically observed with bacterial type primases only. The N. equitans primase (NEQ395) is a highly active primase enzyme synthesizing short RNA primers. Termination occurs preferentially at about nine nucleotides, as determined by HPLC analysis and confirmed with mass spectrometry. Possibly, the compact monomeric primase NEQ395 represents the minimal archaeoeukaryotic primase and could serve as a functional and structural model of the heterodimeric archaeoeukaryotic primases, whose study is hindered by engagement in protein assemblies and rather low activity.
Progesterone receptor mediates ovulatory transcription through RUNX transcription factor interactions and chromatin remodelling
Authors: Dinh Doan T , Breen James , Nicol Barbara , Foot Natalie J , Bersten David C , Emery Alaknanda , Smith Kirsten M , Wong Ying Y , Barry Simon C , Yao Humphrey H C , Robker Rebecca L , Russell Darryl L 
Published: April 2023

Abstract
Progesterone receptor (PGR) plays diverse roles in reproductive tissues and thus coordinates mammalian fertility. In the ovary, rapid acute induction of PGR is the key determinant of ovulation through transcriptional control of a unique set of genes that culminates in follicle rupture. However, the molecular mechanisms for this specialized PGR function in ovulation is poorly understood. We have assembled a detailed genomic profile of PGR action through combined ATAC-seq, RNA-seq and ChIP-seq analysis in wildtype and isoform-specific PGR null mice. We demonstrate that stimulating ovulation rapidly reprograms chromatin accessibility in two-thirds of sites, correlating with altered gene expression. An ovary-specific PGR action involving interaction with RUNX transcription factors was observed with 70% of PGR-bound regions also bound by RUNX1. These transcriptional complexes direct PGR binding to proximal promoter regions. Additionally, direct PGR binding to the canonical NR3C motif enable chromatin accessibility. Together these PGR actions mediate induction of essential ovulatory genes. Our findings highlight a novel PGR transcriptional mechanism specific to ovulation, providing new targets for infertility treatments or new contraceptives that block ovulation.
Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides
Authors: Genna Vito , Iglesias-Fernández Javier , Reyes-Fraile Laura , Villegas Nuria , Guckian Kevin , Seth Punit , Wan Brad , Cabrero Cristina , Terrazas Montserrat , Brun-Heath Isabelle , González Carlos , Sciabola Simone , Villalobos Anabella , Orozco Modesto 
Published: April 2023

AbstractPhosphorothioates (PS) have proven their effectiveness in the area of therapeutic oligonucleotides with applications spanning from cancer treatment to neurodegenerative disorders. Initially, PS substitution was introduced for the antisense oligonucleotides (PS ASOs) because it confers an increased nuclease resistance meanwhile ameliorates cellular uptake and in-vivo bioavailability. Thus, PS oligonucleotides have been elevated to a fundamental asset in the realm of gene silencing therapeutic methodologies. But, despite their wide use, little is known on the possibly different structural changes PS-substitutions may provoke in DNA·RNA hybrids. Additionally, scarce information and significant controversy exists on the role of phosphorothioate chirality in modulating PS properties. Here, through comprehensive computational investigations and experimental measurements, we shed light on the impact of PS chirality in DNA-based antisense oligonucleotides; how the different phosphorothioate diastereomers impact DNA topology, stability and flexibility to ultimately disclose pro-Sp S and pro-Rp S roles at the catalytic core of DNA Exonuclease and Human Ribonuclease H; two major obstacles in ASOs-based therapies. Altogether, our results provide full-atom and mechanistic insights on the structural aberrations PS-substitutions provoke and explain the origin of nuclease resistance PS-linkages confer to DNA·RNA hybrids; crucial information to improve current ASOs-based therapies.
Epidemiology, biology, and management of venous thromboembolism in gliomas: An interdisciplinary review
Authors: Jo Jasmin , Diaz Maria , Horbinski Craig , Mackman Nigel , Bagley Stephen , Broekman Marika , Rak Janusz , Perry James , Pabinger Ingrid , Key Nigel S , Schiff David 
Published: April 2023

Abstract
Patients with diffuse glioma are at high risk of developing venous thromboembolism (VTE) over the course of the disease, with up to 30% incidence in patients with glioblastoma (GBM) and a lower but nonnegligible risk in lower-grade gliomas. Recent and ongoing efforts to identify clinical and laboratory biomarkers of patients at increased risk offer promise, but to date, there is no proven role for prophylaxis outside of the perioperative period. Emerging data suggest a higher risk of VTE in patients with isocitrate dehydrogenase (IDH) wild-type glioma and the potential mechanistic role of IDH mutation in the suppression of production of the procoagulants tissue factor and podoplanin. According to published guidelines, therapeutic anticoagulation with low molecular weight heparin (LMWH) or alternatively, direct oral anticoagulants (DOACs) in patients without increased risk of gastrointestinal or genitourinary bleeding is recommended for VTE treatment. Due to the elevated risk of intracranial hemorrhage (ICH) in GBM, anticoagulation treatment remains challenging and at times fraught. There are conflicting data on the risk of ICH with LMWH in patients with glioma; small retrospective studies suggest DOACs may convey lower ICH risk than LMWH. Investigational anticoagulants that prevent thrombosis without impairing hemostasis, such as factor XI inhibitors, may carry a better therapeutic index and are expected to enter clinical trials for cancer-associated thrombosis.
Regulating the properties of XQ-2d for targeted delivery of therapeutic agents to pancreatic cancers
Authors: Yang Qiuxia , Peng Yongbo , Deng Zhengyu , Zhang Dailiang , Long Cheng-Yu , Zhang Guo-Rong , Li Juan , Wang Xue-Qiang , Tan Weihong 
Published: April 2023

ABSTRACT
Enhanced recognition ability, cell uptake capacity, and biostability are characteristics attributed to aptamer-based targeted anticancer agents, and are possibly associated with increased accumulation at the tumor site, improved therapeutic efficacy and reduced negative side effects. Herein, a phosphorothioate backbone modification strategy was applied to regulate the biomedical properties of pancreatic cancer cell–targeting aptamer for efficient in vivo drug delivery. Specifically, the CD71- targeting aptamer XQ-2d was modified into a fully thio-substituted aptamer S-XQ-2d, improving the plasma stability of S-XQ-2d and mitomycin C (MMC)-functionalized S-XQ-2d (MFSX), thus considerably prolonging their half-life in mice. Moreover, the binding and uptake capacities of S-XQ-2d were significantly enhanced. MFSX showed the same level of cytotoxicity as that of MMC against targeted cancer cells, but lower toxicity to non-targeted cells, highlighting its specificity and biosafety. Brief mechanistic studies demonstrated that XQ-2d and S-XQ-2d had different interaction modes and internalization pathways with the targeted cells.
A versatile model with three-dimensional triangular lattice for unconventional transport and various topological effects
Authors: You Jing-Yang , Su Gang , Feng Yuan Ping 
Published: April 2023

ABSTRACT
The finite Berry curvature in topological materials can induce many subtle phenomena, such as the anomalous Hall effect (AHE), spin Hall effect (SHE), anomalous Nernst effect (ANE), non-linear Hall effect (NLHE) and bulk photovoltaic effects. To explore these novel physics as well as their connection and coupling, a precise and effective model should be developed. Here, we propose such a versatile model—a 3D triangular lattice with alternating hopping parameters, which can yield various topological phases, including kagome bands, triply degenerate fermions, double Weyl semimetals and so on. We reveal that this special lattice can present unconventional transport due to its unique topological surface states and the aforementioned topological phenomena, such as AHE, ANE, NLHE and the topological photocurrent effect. In addition, we also provide a number of material candidates that have been synthesized experimentally with this lattice, and discuss two materials, including a non-magnetic triangular system for SHE, NLHE and the shift current, and a ferromagnetic triangular lattice for AHE and ANE. Our work provides an excellent platform, including both the model and materials, for the study of Berry-curvature-related physics.
A Great late Ediacaran ice age
Authors: Wang Ruimin , Shen Bing , Lang Xianguo , Wen Bin , Mitchell Ross N , Ma Haoran , Yin Zongjun , Peng Yongbo , Liu Yonggang , Zhou Chuanming 
Published: April 2023

ABSTRACT
The emergence of the Ediacara biota soon after the Gaskiers glaciation ca. 580 million years ago (Ma) implies a possible glacial fuse for the evolution of animals. However, the timing of Ediacaran glaciation remains controversial because of poor age constraints on the ∼30 Ediacaran glacial deposits known worldwide. In addition, paleomagnetic constraints and a lack of convincing Snowball-like cap carbonates indicate that Ediacaran glaciations likely did not occur at low latitudes. Thus, reconciling the global occurrences without global glaciation remains a paradox. Here, we report that the large amplitude, globally synchronous ca. 571–562 Ma Shuram carbon isotope excursion occurs below the Ediacaran Hankalchough glacial deposit in Tarim, confirming a post-Shuram glaciation. Leveraging paleomagnetic evidence for a ∼90° reorientation of all continents due to true polar wander, and a non-Snowball condition that rules out low-latitude glaciations, we use paleogeographic reconstructions to further constrain glacial ages. Our results depict a ‘Great Ediacaran Glaciation’ occurring diachronously but continuously from ca. 580–560 Ma as different continents migrated through polar–temperate latitudes. The succession of radiation, turnover and extinction of the Ediacara biota strongly reflects glacial–deglacial dynamics.