bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variation in Medicaid and commercial payer coverage of aducanumab for Alzheimer's disease
Authors: Lin Pei‐Jung , Levine Adele , Rucker Julia , Chambers James D. 
Published: February 2023

AbstractIntroductionEver since the United States Food and Drug Administration (FDA) approved aducanumab and Centers for Medicare & Medicaid Service (CMS) restricted coverage for the drug, a crucial question has been how other payers will behave. This study examined how Medicaid and commercial plans cover aducanumab.MethodsWe created a database of aducanumab coverage policies issued by Medicaid fee‐for‐service programs (50 states and DC) and 35 of the largest commercial plans (covering ∼ 84% of the commercially insured population).ResultsWe found that only 41% of Medicaid fee‐for‐service plans have issued a publicly available coverage policy for aducanumab and that there is wide variation in these coverage criteria. Although the majority of included commercial plans have issued an aducanumab coverage policy, only five plans covered aducanumab for their enrollees. Available coverage polices showed little consistency in how to measure sufficient treatment response.DiscussionDifferences in coverage policies mean that Alzheimer's patients’ access to aducanumab may vary across jurisdictions and across commercial insurers.Highlights
Less than half of state Medicaid fee‐for‐service plans issued a publicly available coverage policy for aducanumab.
Available Medicaid coverage policies varied substantially in their coverage criteria.
The majority of included commercial plans issued an aducanumab coverage policy; only five plans covered aducanumab.
Available coverage polices showed little consistency in how to measure sufficient treatment response.
Porous Covalent Organic Framework Based Hydrogen‐Bond Nanotrap for the Precise Recognition and Separation of Gold
Authors: Qiu Jikuan , Xu Chang , Xu Xianhui , Zhao Yingjie , Zhao Yang , Zhao Yuling , Wang Jianji 
Published: February 2023

AbstractUtilizing weak interactions to effectively recover and separate precious metals in solution is of great importance but the practice remains a challenge. Herein, we report a novel strategy to achieve precise recognition and separation of gold by regulating the hydrogen‐bond (H‐bond) nanotrap within the pore of covalent organic frameworks (COFs). It is found that both COF‐HNU25 and COF‐HNU26 can efficiently capture AuIII with fast kinetics, high selectivity, and uptake capacity. In particular, the COF‐HNU25 with the high density of H‐bond nanotraps exhibits an excellent gold uptake capacity of 1725 mg g−1, which is significantly higher than that (219 mg g−1) of its isostructural COF (COF‐42) without H‐bond nanostrap in the pores. Importantly, the uptake capacity is strongly correlated to the number of H‐bonds between phenolic OH in the COF and [AuCl4]− in water, and multiple H‐bond interactions are the key driving force for the excellent gold recovery and reusability of the adsorbent.
Supercritical CO2‐Induced Amorphization in 2D Materials: Mechanism and Applications
Authors: Ge Tianpei , Cui Wenui , Xu Qun 
Published: February 2023

AbstractSupercritical carbon dioxide (SC CO2)‐assisted chemical and material processing has shown great success in the fabrication of 2D amorphous materials, while the amorphization mechanism in SC CO2 is quite complicated to be understand. In this review, we introduce different kinds of 2D amorphous materials prepared with SC CO2 and discuss the possible amorphization mechanism and how they affect the structures and properties of 2D materials. Their applications are further presented and discussed. In addition, the prospective of future development of SC CO2‐assisted fabrication of 2D amorphous materials is also involved. The investigation of SC CO2 induced amorphization not only provides theoretic understanding of amorphization process, but also directs to the preparation and application of 2D amorphous materials with specific structure and property, suggesting the promising future of SC CO2‐assisted process in material design and engineering.
Dynamically Resettable Electrode‐Electrolyte Interface through Supramolecular Sol‐Gel Transition Electrolyte for Flexible Zinc Batteries
Authors: Li Pengzhou , Liao Meng , Cui Shuquan , Li Jiaxin , Ye Lei , Yang Yibei , Wang Chuang , Wang Bingjie , Peng Huisheng 
Published: February 2023

AbstractFlexible batteries based on gel electrolytes with high safety are promising power solutions for wearable electronics but suffer from vulnerable electrode‐electrolyte interfaces especially upon complex deformations, leading to irreversible capacity loss or even battery collapse. Here, a supramolecular sol‐gel transition electrolyte (SGTE) that can dynamically accommodate deformations and repair electrode‐electrolyte interfaces through its controllable rewetting at low temperatures is designed. Mediated by the micellization of polypropylene oxide blocks in Pluronic and host‐guest interactions between α‐cyclodextrin (α‐CD) and polyethylene oxide blocks, the high ionic conductivity and compatibility with various salts of SGTE afford resettable electrode‐electrolyte interfaces and thus constructions of a series of highly durable, flexible aqueous zinc batteries. The design of this novel gel electrolyte provides new insights for the development of flexible batteries.
pH‐Triggered Molecular Switch Toward Texture‐Regulated Zn Anode
Authors: Zhang Shao‐Jian , Hao Junnan , Zhu Yilong , Li Huan , Lin Zhan , Qiao Shi‐Zhang 
Published: February 2023

AbstractZn electrodes in aqueous media exhibit an unstable Zn/electrolyte interface due to severe parasitic reactions and dendrite formation. Here, a dynamic Zn interface modulation based on the molecular switch strategy is reported by hiring γ‐butyrolactone (GBL) in ZnCl2/H2O electrolyte. During Zn plating, the increased interfacial alkalinity triggers molecular switch from GBL to γ‐hydroxybutyrate (GHB). GHB strongly anchors on Zn surface via triple Zn−O bonding, leading to suppressive hydrogen evolution and texture‐regulated Zn morphology. Upon Zn stripping, the fluctuant pH turns the molecular switch reaction off through the cyclization of GHB to GBL. This dynamic molecular switch strategy enables high Zn reversibility with Coulombic efficiency of 99.8 % and Zn||iodine batteries with high‐cyclability under high Zn depth of discharge (50 %). This study demonstrates the importance of dynamic modulation for Zn electrode and realizes the reversible molecular switch strategy to enhance its reversibility.
Preparation of porous poly(4‐tert‐butylstyrene) based monoliths with high efficiency for oil‐water separation via high internal phase emulsion template
Authors: Zhao Yulai , Shen Lianzhi , Yuan Yu , Xiao Longqiang , Cai Jingyu , Lu Zhen , Hou Linxi 
Published: February 2023

AbstractDeveloping low‐cost and highly efficient hydrophobic absorbents via simple and environmentally friendly method is demanded for oil‐water separation. This paper reports the preparation of hydrophobic absorbents of porous poly(4‐tert‐butylstyrene‐co‐divinylbenzene) (poly(tBS‐co‐DVB)) via high internal phase emulsion (HIPE) template method. The effects of crosslinking degree and internal phase volume fraction on the porous structure and adsorption performance of the absorbents are investigated. As the tBS/DVB molar ratio increases from 1:1 to 4:1, the adsorption performance of poly(tBS‐co‐DVB) toward hexane first increases to a maximum at a molar ratio of 3:1 and then decreases. As the internal phase volume fraction increases, the specific surface area (SSA) and porosity of the poly(tBS‐co‐DVB)s notably increase from 33.06 m2/g and 84.07% to 102.89 m2/g and 92.94%, respectively. When the internal phase fraction is 95 vol%, the obtained poly(tBS‐co‐DVB) foam with a water contact angle of 140° shows an absorbing capacity as high as 70.21 g/g for dichloromethane. After 10 consecutive adsorption‐desorption cycles, the adsorption performance of the poly(tBS‐co‐DVB) foam shows only a slight decrease, indicating an excellent recycling ability. The obtained poly(tBS‐co‐DVB) foams exhibit the advantages of facile preparation, high oil absorption capacity and satisfactory recoverability, which enable them potential as sustainable oil adsorbents.
Post‐release survival of shortfin mako (Isurus oxyrinchus) and silky (Carcharhinus falciformis) sharks released from pelagic tuna longlines in the Pacific Ocean
Authors: Francis Malcolm P. , Lyon Warrick S. , Clarke Shelley C. , Finucci Brittany , Hutchinson Melanie R. , Campana Steven E. , Musyl Michael K. , Schaefer Kurt M. , Hoyle Simon D. , Peatman Tom , Bernal Diego , Bigelow Keith , Carlson John , Coelho Rui , Heberer Craig , Itano David , Jones Emma , Leroy Bruno , Liu Kwang‐Ming , Murua Hilario , Poisson François , Rogers Paul , Sanchez Caroline , Semba Yasuko , Sippel Tim , Smith Neville 
Published: February 2023

Abstract

Substantial global population declines in pelagic sharks have led to the introduction of management and conservation measures, including gear restrictions and no‐retention policies, to curb declines and encourage stock recovery. As the rate of discarding sharks increases, there is a growing need to understand prognostic factors that influence their post‐release survival (PRS) outcomes.
PRS was measured with survival pop‐up satellite archival tags attached to shortfin mako (Isurus oxyrinchus) and silky sharks (Carcharhinus falciformis) released or discarded from pelagic tuna longline fishing vessels operating in the Western and Central Pacific Fisheries Commission Convention Area. In total, 117 tags were deployed on 60 mako and 57 silky sharks captured as bycatch during commercial pelagic longline fishing trips in New Zealand (n = 35), Fiji (n = 58), New Caledonia (n = 10) and the Republic of the Marshall Islands (n = 14).
Mako engaged in long‐distance movements between New Zealand, Australia, Fiji and New Caledonia, while silky sharks tagged in the Marshall Islands showed evidence of seasonal movements eastward.
PRS was determined for 110 sharks (57 mako, 53 silky sharks). Most tagged sharks of both species were uninjured (89%) at capture and most sharks (88%) survived post‐release until tag loss or the programmed pop‐up date (60 days). However, when considering a complete fishing interaction (haulback, handling, release), PRS estimates were markedly reduced to 48.6% and 52.3% for mako and silky sharks, respectively. For both species, survivorship was greater in large (>150 cm fork length) uninjured sharks and sharks released with low shark length to trailing branchline ratios.
While these findings suggest that retention bans offer sharks an increased chance of survival, continued efforts should be made to improve handling and release practices, reduce trailing gear and minimize pelagic shark bycatch.
Pharmacokinetics and bioequivalence studies of fluvoxamine maleate tablets in healthy Chinese subjects
Authors: She Ding‐ping , He Ying , Li Ming‐qu , Su Li , Ren Di , Huang Xiao‐han , Zhang Yu‐Hua , Hu Hai‐tang , Deng De‐cheng , Wu Jian‐long 
Published: February 2023

AbstractFluvoxamine is a selective serotonin reuptake inhibitor commonly used for various types of depression. The purpose of this study was to evaluate the pharmacokinetics and bioequivalence of fluvoxamine maleate tablets orally on an empty stomach and after a meal in healthy adult Chinese subjects and to preliminarily evaluate their safety. A single‐center, randomized, open‐label, two‐drug, two‐period, crossover, single‐dose trial protocol was designed. Sixty healthy Chinese participants were enrolled and randomly classified into fasting (n = 30) and fed groups (n = 30). Each week, subjects took fluvoxamine maleate tablets 50 mg orally once as a test preparation or as a reference preparation on an empty stomach/after meals. To evaluate the bioequivalence of test and reference tables, the concentration of fluvoxamine maleate in the plasma of the subjects at different time points after administration was detected by liquid chromatography–tandem mass spectrometry, and pharmacokinetic parameters including the maximum plasma drug concentration (Cmax), the time to reach maximum concentration (Tmax), the area under the plasma concentration–time curve from time 0 to the last measurable concentration (AUC0–t) and the area under the plasma concentration–time curve from time 0 to infinity (AUC0–∞) were calculated. Our data revealed that the 90% confidence intervals of the geometric mean ratio of the test or reference drugs for the Cmax, AUC0–t and AUC0–∞ fell within the acceptance range for bioequivalence (92.30–102.77%). The absorption, measured by AUC, did not show a significant difference between the two groups. There were no suspected serious adverse reactions or serious adverse events over the entire trial. Our results demonstrated that the test and reference tablets were bioequivalent under fasting and fed conditions.
Computer educators' perception of the utilization of online assessment in the Covid‐19 era
Authors: Lu Shaohua , Eloanyi Chekwube B. , Olelewe Chijioke J. 
Published: February 2023

AbstractThe proliferation of ICT in today's world of work particularly in education has necessitated the need to assess lecturers' views of online assessment use in the covid‐19 era given the disruptions in face‐to‐face teaching and learning process. The study adopted a mixed research design. The population for the study was 84 computer educators made up of 40 males and 44 females from the four public tertiary institutions in Enugu State, Nigeria. Three research questions and two hypotheses guided the study. The instruments used for data collection were a structured questionnaire titled “Computer Educators' Perception of Use of Online Assessment” (CEPUOA) and a guided interview relating to the research questions. The internal consistency was determined using the Cronbach α reliability test which gave an index of .9. The data collected were analyzed using mean and standard deviation while the null hypotheses were tested using a t‐test at 0.05 level of significance. The findings of the study indicated that computer educators have a positive disposition toward the use of online assessment in conducting various assessment techniques such as tests/quizzes, semester examinations, and seminar/project evaluations. The findings of the study further showed that the utilization of online assessment techniques facilitates timely monitoring of students' progress, and the provision of immediate feedback to the learners helps in preparing students with digital skills required to function in the 21st‐century workplace, among others. In view of these, it was recommended that tertiary institutions should initiate workable policies that will encourage the effective use of online assessment by lecturers.
Exploring the inhibitory effect of maximising mindset on impulse buying
Authors: Ding Zhoujin , Tu Ming , Guo Zizheng 
Published: February 2023

AbstractAlthough impulse buying could temporarily increase sales, it is essential to explore how to curb impulse buying because impulse buying leads to negative consequences for both consumers and enterprises in the long run. Previous research investigated the negative correlation between impulse buying and situational factors or personal traits. However, these factors were complicated for marketers or consumers to manipulate, so the research gap was that a lack of research focused on how to curb impulse buying through external intervention. This study aimed to find an effective external intervention to curb impulse buying and thus fill the blanket. This study introduced maximising mindset, a mindset that could be manipulated externally and used effectively by consumers and marketers to curb impulse buying. Data were collected online from 1106 participants in China through the research platform Sojump. The results demonstrated that maximising mindset negatively correlated with impulse buying, and future‐oriented thinking played a role as a mediator. This study contained theoretical for future research on impulse buying and practical value in helping consumers achieve better decisions and helping companies achieve long‐term growth.
Co‐translational Installation of Posttranslational Modifications by Non‐canonical Amino Acid Mutagenesis
Authors: Niu Wei , Guo Jiantao 
Published: February 2023

AbstractProtein posttranslational modifications (PTMs) play critical roles in regulating cellular activities. Here we provide a survey of genetic code expansion (GCE) methods that were applied in the co‐translational installation and studies of PTMs through noncanonical amino acid (ncAA) mutagenesis. We begin by reviewing types of PTM that have been installed by GCE with a focus on modifications of tyrosine, serine, threonine, lysine, and arginine residues. We also discuss examples of applying these methods in biological studies. Finally, we end the piece with a short discussion on the challenges and the opportunities of the field.
Iridium Incorporation into MnO2 for an Enhanced Electrocatalytic Oxygen Evolution Reaction
Authors: Kakati Uddipana , Elzinga Evert J. , Mansley Zachary R. , Roe Benjamin , Alimohammadi Farbod , Schwenk Gregory , Ning Jinliang , Zhu Yimei , Ji Hai‐Feng , Sun Jianwei , Strongin Daniel R. 
Published: February 2023

AbstractWe have investigated the structure and activity of electrocatalysts for the oxygen evolution reaction (OER) that had low loadings of Ir incorporated into the 2D layered MnO2, (birnessite, nominally δ‐MnO2) and the 3D MnO2 (pyrolusite, β‐MnO2). The Ir‐incorporated β‐MnO2 (Ir/β‐MnO2) electrocatalysts were prepared for the first time via a thermally induced phase transition of δ‐MnO2 containing 16–22 wt% Ir. This phase transition of δ‐MnO2 to β‐MnO2 was facilitated by the presence of Ir in the structure, as both Ir in IrO2 and Mn in β‐MnO2 could adopt a thermodynamically favored rutile structure. Extended X‐ray absorption fine structure (EXAFS) of Ir/β‐MnO2 showed that the catalyst consisted of Ir substituted into the crystalline β‐MnO2 lattice. 22 wt% Ir/β‐MnO2 (60
) exhibited an OER overpotential (
) of 337 mV, lower than the
for commercial IrO2. This
was constant for 6 h, at 10 mA
in 0.5 M H2SO4. EXAFS, high‐angle annular dark‐field scanning transmission electron microscopy (HAADF‐STEM) and X‐ray absorption near edge structure (XANES) showed that 22 wt% Ir/β‐MnO2 had a strained structure containing ∼41 % Mn3+, an OER active species, along with a modified Ir bond covalency consisting of both Ir−O−Ir and Ir−O−Mn.
Bunno's Fabulous Soap‐Making Challenge – Educational Concept, Game Design, and Initial Evaluation
Authors: Cermak-Sassenrath Daniel , Solmaz Serkan , Alfaro Jessica L. Dominguez , Udeozor Chioma 
Published: February 2023

AbstractBunno's Fabulous Soap‐Making Challenge is intended to be both a game that is played for fun and a game from which subject content can be learned. The game is a resource‐managing game in which players plan, organize, and execute the production of soap. This article critically discusses the game concept. It also describes the educational theory, the game design as well as the educational content and the projected learning outcomes of the game. The results of an initial evaluation of the game are presented. A mixed‐methods approach finds that players enjoyed playing the game. The players make several recommendations, including the addition of specific game mechanics that offer players a greater level of in‐game control and increasing the challenge and complexity of the game.
Crystalline Order Propagates Across Thick Layers of Water in Solutions of Supramolecular Nanotubes
Authors: Huang Ningdong , Huang Weiheng , Luo Zhenlin , Chu Wangsheng , Ungar Goran 
Published: February 2023

Abstract3D crystalline order with 1 nm resolution is observed in aqueous solutions of supramolecular nanotubes containing 94 % water, at concentrations as low as 6 wt%. 50 of star‐like organic ions arrange into supramolecular rings which, in turn, stack on top of each other to form long hollow tubes with 15 nm outer diameter. Cryo‐TEM and X‐ray diffraction show that the parallel nanotubes arrange on a perfect hexagonal lattice. Unexpectedly, fiber diffraction on sheared solutions revealed numerous hkl Bragg reflections on several layer lines indicating longitudinal interlock between the tubes and 3D crystalline order with molecular‐scale details transferred across 10 nm thick layers of water. The observed high 3D order is attributed to long‐range attraction between like‐charged tubes and amplified charge modulation by the extremely high intra‐tube correlation length.
Effect of Multiple Doses of Sparsentan on the Single‐Dose Pharmacokinetics of Dapagliflozin: An Open‐Label Drug–Drug Interaction Study in Healthy Adults
Authors: Chen Shang‐Chiung , Cai Danlin , Winnett Claire , Nguyen Mai , Verma Neeraj , Liu Kai , Preciado Priscila 
Published: February 2023

AbstractSparsentan is a single‐molecule dual antagonist of the endothelin type A receptor and angiotensin II type 1 receptor under investigation for the treatment of focal segmental glomerulosclerosis and immunoglobulin A nephropathy. Dapagliflozin, a sodium‐glucose cotransporter 2 inhibitor, has recently been indicated in chronic kidney disease. Sparsentan may be considered for concomitant use with dapagliflozin. The purpose of this open‐label, 1‐sequence crossover study was to determine whether drug–drug interactions between sparsentan and dapagliflozin affect dapagliflozin pharmacokinetics (PK). In addition, exposure to the inactive metabolite of dapagliflozin, dapagliflozin‐3‐O‐glucuronide, was used to evaluate the effect of sparsentan on the primary metabolizing enzyme of dapagliflozin, uridine 5′‐diphospho‐glucuronosyltransferase 1A9. The study included 22 healthy adults treated with 10 mg of dapagliflozin on day 1, and 800 mg/day of sparsentan on days 5–14, with a 10‐mg dose of dapagliflozin coadministered on day 11. PK samples were taken for dapagliflozin, dapagliflozin‐3‐O‐glucuronide, and sparsentan before and after treatment throughout the study. Steady‐state concentrations of sparsentan following daily dosing did not affect the PK of single‐dose dapagliflozin in healthy adults. Dapagliflozin‐3‐O‐glucuronide PK suggests a minimal effect of sparsentan on metabolism of dapagliflozin by uridine 5′‐diphospho‐glucuronosyltransferase 1A9. No deaths, serious adverse events, or unusual safety signals occurred. Results suggest dapagliflozin PK is not affected by sparsentan daily dosing.
Parallel aeroacoustic computation of unsteady transonic weapon bay using detached‐eddy simulation via open computational fluid dynamics source codes
Authors: Fadıl Ali Can , Zafer Baha 
Published: February 2023

SummaryCavity flow research has been ongoing experimentally since the 1940s, especially for weapon bay use in fighter aircraft. Technology advancement has led to the beginning of simulations of experimental studies. The success of these simulations has increased with the emergence of High‐Performance Clusters, and simulation studies have started to take the role of experimental studies. In this paper, an open rectangular, unsteady transonic cavity with a length to depth ratio of 5, Mach number 0.85 and Reynolds number of approximately 6.5 × 106 is simulated using Computational Fluid Dynamics (CFD) on a High‐Performance Cluster. Likewise, cavity door is used to model a real weapon bay. Detached‐Eddy Simulation is used to resolve turbulent properties in the flow domain. Results compatible with experimental data are obtained with OpenFOAM, an open‐source CFD code based on the finite volume method. Additionally, computational costs are given in the clock‐time analysis section, and the necessity of high‐performance clusters for CFD and Computational Aeroacoustics studies is emphasized.