bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Literature Review on Battery Management Systems and predicting Solar Big Data
Authors: Padeli Padeli , Sudaryono Sudaryono , Pandiangan Ridwan Alberto 
Published: September 2023

Penelitian ini bertujuan untuk menganalisis sistem manajemen baterai dengan memprediksi tenaga surya melalui bigdata ditinjau dari kajian literatur. Dengan adanya pertumbuhan biaya integrasi, pengelolaan limbah yang semakin rumit, variabilitas daya listrik yang berdampak sosio-lingkungan sehingga membutuhkan model sektor listrik baru dengan memanfaatkan tenaga surya. Oleh karenanya penelitian ini merupakan hasil tinjauan literature review dengan prinsip systematic literature review untuk memprediksi tenaga surya dalam pengelolaan listrik dengan sistem baterai. Metode Systematic Literature Review (SLR) digunakan untuk mendefinisikan dan mengevaluasi literatur dalam rangkaian makalah. Pencarian menggunakan 41 makalah untuk evaluasi sebelumnya, menunjukkan bahwa model yang digunakan untuk memprediksi tenaga surya adalah eksperimen akademik jangka panjang. Algoritma ELM (Extreme Learning Machine) menjadi pilihan dalam pengelolaan listrik dengan tenaga surya melalui system baterai dibandingkan dengan algoritma JST (Jaringan Syaraf Tiruan).
Do The Core Stability and Position Sense of Trunk Affect Balance in Patients with Multiple Sclerosis?
Authors: ÖZKAN Taşkın , GÜÇLÜ GÜNDÜZ Arzu , SOKE Fatih , ÖZKUL Çağla , APAYDIN Yasemin , ELDEMİR Kader , İRKEÇ Ceyla 
Published: September 2023

Objective: The trunk is known to be the most important key point where sensory inputs are received and motor responses occur, necessary for the maintenance of balance and postural control. The aims of the present study were to investigate the relationship between balance with core stability and position sense of trunk in patients with Multiple Sclerosis (PwMS) and to compare core stability, position sense of trunk and balance in PwMS and healthy controls.
Methods: The study was completed with 45 PwMS and 29 healthy controls with matching age and gender. Balance was assessed with Postural Stability Test (PST) and Modified Sensory Organization Test (MSOT) by using Biodex Balance System®. Core stability was evaluated with core endurance tests according to McGill procedure. Position sense of trunk was evaluated with the lumbosacral (LS) reposition tests by using Dualer IQTM digital inclinometer.
Results: PST, MSOT and LS repositioning tests scores were higher (p
Correlation Between the Level od Atherosclerosis and Pathological Features of Coronary Artery Disease: A Study of 100 Autopsy Cases
Authors: TURAN YURTSEVER Nurşen , EKEMEN Süheyla , KETENCİ Hüseyin Çetin 
Published: September 2023

Objective: Atherosclerosis is a generalized, chronic disease of large and medium-sized muscular elastic arteries. Relation between intensity of atherosclerosis and coronary artery disease, and risk factors of atherosclerosis could not been revealed completely by autopsy studies. We aimed to renew this shortage of knowledge with our autopsy study prospectively.
Methods: One hundred cases were autopsied within 48 h after death. Atherosclerotic risk factor data were collected including age, gender, height, weight, smoking and any chronic coronary artery disease. Atherosclerosis severity was evaluated macroscopically by examining the inner surfaces of the vascular lumens and revealed with postmortem pathological findings of coronary artery disease.
Results: The mean age was 42 ± 22 years. Seventy-four percent of cases were male, while 26% were female. Smoking duration ranged from 1 to 50 years with a mean duration of 17 ± 12 years. Existence of atherosclerosis in main vessels were also in correlation with age, duration of smoking and BMI (Body Mass Index) (p
Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade
Authors: GÖKKAYA İçim , RENDA Gülin , SUBAŞ Tuğba , ÖZGEN Ufuk 
Published: September 2023

Objective: Plants have been used to treat ailments since the dawn of humanity. The use of medicinal plants for various purposes such as preventing diseases, treating diseases and supporting medical treatment is increasing day by day. On the other hand, medicinal plants are important sources of raw materials for the pharmaceutical industry. It has been demonstrated that Peganum harmala L. and the phytochemicals it contains have a wide variety of pharmacological activities. P. harmala and its active ingredients can be an important resource for the pharmaceutical industry. In this review, the phytochemistry, pharmacological effects, clinical studies, and toxicity of P. harmala are discussed under the current information.
Methods: Studies on P. harmala were searched using Pubmed, Scopus, Science Direct databases, and Google Scholar search engine. As a result of the searches, 96 articles were included in the study.
Results: The main group of secondary metabolites responsible for the biological activities of P. harmala is alkaloids. The plant and its isolated secondary plant compounds have been shown to have many pharmacological actions, counting antiamnestic, anticancer, antidepressant, antiinflammatory, cardiovascular, gastroprotective, hepatoprotective, nephroprotective, and vasodilator activities. Studies evaluating the plant's clinical effects have been carried out in recent years. However, it has been recorded in the literature that the use of P. harmala causes poisoning with symptoms such as neurosensory symptoms, visual hallucination, bradycardia, hypotension, agitation, tremor, ataxia, and vomiting. Conclusion: Considering the pharmacological effects, the number of studies on the efficacy and safety of P. harmala and its secondary metabolites should be increased.
Cellular, Behavioral, and Locomotor Effects of Oral Nicotine in Male Rats with Bilateral Lesions in the Ventrolateral Striatum Induced with 6-OHDA
Authors: SARICA  DAROL Elif , KARSON Ayşe , KÖKTÜRK Sibel , İŞERİ Pervin 
Published: September 2023

Objective: Parkinson's disease is a progressive neurodegenerative disease having a spectrum of non-motor to motor symptoms. Unrelated to motor symptoms of sensory, autonomic, and neuropsychiatric symptoms often appear early in the course of the disease. It is a remarkable observation that patients in the premotor phase can easily quit smoking without help. This study was intended to investigate the interrelation between nicotine and the partial loss of dopaminergic innervation in the ventrolateral striatum induced by 6-OHDA.
Methods: We used an experimental premotor parkinsonism model. The oral nicotine preference of rats was investigated with the two-bottle free choice method. The behaviors related to locomotor activity and emotional state were evaluated with a locomotor activity test, elevated plus maze, and forced swimming test. Histopathological evaluation was performed in the striatum by staining techniques using hematoxylin+eosin (H&E) and immunohistochemistry markers (caspase-3, and MAP-2).
Results: Bilateral 6-OHDA lesions did not lead to a significant alteration in the total locomotor activity or nicotine preference. Nicotine increased horizontal but decreased vertical movements in addition to increasing anxiolytic but also depressive effects in the OHDA lesion group. The number of apoptotic cells was significantly lower in the lesion group receiving nicotine compared to those not receiving nicotine.
Conclusion: Our experimental study points to the role of oral nicotine in male rats with bilateral striatal 6-OHDA lesions in the ventrolateral striatum. Further studies are needed to understand the relationship between loss of dopaminergic innervation in the striatum and nicotine consumption.
Smoking, immunity, and cardiovascular prognosis: a study of plasma IgE concentration in patients with acute myocardial infarction
Authors: Zhang Lili , Zhu Yanrong , Meng Xin , Zhang Yifan , Ren Qian , Huang Dong , Chen Zhong 
Published: September 2023

BackgroundImmunoglobulin E (IgE) is implicated in the pathogenesis of acute myocardial infarction (AMI), and smokers often exhibit elevated plasma IgE levels. However, it remains uncertain whether the role of smoking in the development and prognosis of AMI is influenced by IgE levels. This study aimed to investigate the potential contribution of IgE in mediating the association between smoking and AMI.MethodsWe conducted a prospective study involving 348 consecutive patients with chest discomfort who underwent coronary angiography. Plasma cotinine, an alkaloid present in tobacco, and IgE levels were measured. The patients were followed up for mean 39-months to assess their long-term prognosis based on major adverse cardiac and cerebrovascular events (MACCE).ResultsOur findings indicate that patients with AMI had higher plasma levels of cotinine and IgE. Univariate analyses demonstrated a positive association between plasma cotinine (OR = 1.7, 95% CI: 1.27–2.26, P &lt; 0.001) and IgE (OR = 2.8, 95% CI: 1.75–4.39, P &lt; 0.001) with AMI. Receiver operating characteristics analyses showed that the combined use of cotinine and IgE (AUC: 0.677) had a larger predictive performance compared to cotinine alone (AUC: 0.639) or IgE alone (AUC: 0.657), although the improvement did not reach statistical significance. Multivariable logistic regression revealed a positive association between plasma cotinine and AMI (OR = 1.70, 95% CI: 1.04–2.78, P = 0.036). Furthermore, the inclusion of plasma IgE in the regression model led to a decrease in the OR and 95% CI of plasma cotinine (OR = 1.66, 95% CI: 1.01–2.73, P = 0.048). Process mediation analyses showed a significant indirect effect of plasma cotinine on AMI mediated through increased plasma IgE. Kaplan–Meier analysis during a mean 39-months follow-up revealed that higher plasma levels of IgE were associated with an increased risk of MACCE following AMI (P = 0.047). However, in the context of the COX regression analysis, no significant correlation was observed between IgE, cotinine and AMI.ConclusionCotinine exhibits a positive association with AMI, wherein IgE plays a mediating role. Elevated plasma levels of IgE was positively associated with AMI and poor prognosis, which further confirms the adverse role of smoking on the incidence of AMI and prognosis. (Clinical trial registration: ChiCTR2100053000).
Integrated 16S rRNA sequencing and nontargeted metabolomics analysis to reveal the mechanisms of Yu-Ye Tang on type 2 diabetes mellitus rats
Authors: Ma Ziang , Sun Wenjuan , Wang Lixin , Wang Yuansong , Pan Baochao , Su Xiuhai , Li Hanzhou , Zhang Hui , Lv Shuquan , Wang Hongwu 
Published: September 2023

IntroductionYu–Ye Tang (YYT) is a classical formula widely used in treatment of type 2 diabetes mellitus (T2DM). However, the specific mechanism of YYT in treating T2DM is not clear.MethodsThe aim of this study was to investigate the therapeutic effect of YYT on T2DM by establishing a rat model of T2DM. The mechanism of action of YYT was also explored through investigating gut microbiota and serum metabolites.ResultsThe results indicated YYT had significant therapeutic effects on T2DM. Moreover, YYT could increase the abundance of Lactobacillus, Candidatus_Saccharimonas, UCG-005, Bacteroides and Blautia while decrease the abundance of and Allobaculum and Desulfovibrio in gut microbiota of T2DM rats. Nontargeted metabolomics analysis showed YYT treatment could regulate arachidonic acid metabolism, alanine, aspartate and glutamate metabolism, arginine and proline metabolism, glycerophospholipid metabolism, pentose and glucuronate interconversions, phenylalanine metabolism, steroid hormone biosynthesis, terpenoid backbone biosynthesis, tryptophan metabolism, and tyrosine metabolism in T2DM rats.DiscussionIn conclusion, our research showed that YYT has a wide range of therapeutic effects on T2DM rats, including antioxidative and anti-inflammatory effects. Furthermore, YYT corrected the altered gut microbiota and serum metabolites in T2DM rats. This study suggests that YYT may have a therapeutic impact on T2DM by regulating gut microbiota and modulating tryptophan and glycerophospholipid metabolism, which are potential key pathways in treating T2DM.
Do large thyroid nodules (≥4 cm) without suspicious cytology need surgery?
Authors: Kang Seokmin , Kim Eunjin , Lee Sunmin , Kim Jin Kyong , Lee Cho Rok , Kang Sang-Wook , Lee Jandee , Jeong Jong Ju , Nam Kee-Hyun , Chung Woong Youn 
Published: September 2023

BackgroundFine-needle aspiration biopsy (FNAB) is a good diagnostic tool for thyroid nodules; however, its high false-negative rate for giant nodules remains controversial. Many clinicians recommend surgical resection for nodules &gt;4 cm owing to an increased risk of malignancy and an increased false-negative rate. This study aimed to examine the feasibility of this approach and investigate the incidence of malignancy in thyroid nodules &gt;4 cm without suspicious cytology based on medical records in our center.MethodsThis was a retrospective analysis of 453 patients that underwent preoperative FNAB for nodules measuring &gt;4 cm between January 2017 and August 2022 at Severance Hospital, Seoul.ResultsAmong the 453 patients, 140 nodules were benign and 119 were indeterminate. Among 259 patients, the final pathology results were divided into benign (149) and cancerous (110) groups, and the prevalence of malignancy was 38.9% in the benign group and 55.5% in the indeterminate group. Among the malignancies, follicular carcinoma and follicular variants of papillary carcinoma were observed in 83% of the cytologically benign group and 62.8% of the indeterminate group.ConclusionPreoperative FNAB had high false-negative rates and low diagnostic accuracy in patients with thyroid nodules &gt;4 cm without suspicious cytologic features; therefore, diagnostic surgery may be considered a treatment option.
From goals to engagement—evaluating citizen science project descriptions as science communication texts
Authors: Golumbic Yaela N. , Oesterheld Marius 
Published: September 2023

Introduction: Attracting and recruiting volunteers is a key aspect of managing a citizen science initiative. Science communication plays a central role in this process. In this context, project descriptions are of particular importance, as they are very often, the first point of contact between a project and prospective participants. As such, they need to be reader-friendly, accessible, spark interest, contain practical information, and motivate readers to join the project.Methods: This study examines citizen science project descriptions as science communication texts. We conducted a thorough review and analysis of a random sample of 120 English-language project descriptions to investigate the quality and comprehensiveness of citizen science project descriptions and the extent to which they contain information relevant to prospect participants.Results: Our findings reveal information deficiencies and challenges relating to clarity and accessibility. While goals and expected outcomes were frequently addressed, practical matters and aspects related to volunteer and community management were much less well-represented.Discussion: This study contributes to a deeper understanding of citizen science communication methods and provides valuable insights and recommendations for enhancing the effectiveness and impact of citizen science.
Reducing carbon emissions in the architectural design process via transformer with cross-attention mechanism
Authors: Li HuaDong , Yang Xia , Zhu Hai Luo 
Published: September 2023

IntroductionThe construction industry is one of the world’s largest carbon emitters, accounting for around 40% of total emissions. Therefore, reducing carbon emissions from the construction sector is critical to global climate change mitigation. However, traditional architectural design methods have some limitations, such as difficulty in considering complex interaction relationships and a large amount of architectural data, so machine learning can assist architectural design in improving design efficiency and reducing carbon emissions.MethodsThis study aims to reduce carbon emissions in the architectural design by using a Transformer with a cross-attention mechanism model. We aim to use machine learning methods to generate optimized building designs that reduce carbon emissions during their use and construction. We train the model on the building design dataset and its associated carbon emissions dataset and use a cross-attention mechanism to let the model focus on different aspects of the building design to achieve the desired outcome. We also use predictive modelling to predict energy consumption and carbon emissions to help architects make more sustainable decisions.Results and discussionExperimental results demonstrate that our model can generate optimized building designs to reduce carbon emissions during their use and construction. Our model can also predict a building’s energy consumption and carbon emissions, helping architects make more sustainable decisions. Using Transformers with cross-attention mechanism models to reduce carbon emissions in the building design process can contribute to climate change mitigation. This approach could help architects better account for carbon emissions and energy consumption and produce more sustainable building designs. In addition, the method can also guide future building design and decision-making by predicting building energy consumption and carbon emissions.
eoPred: predicting the placental phenotype of early-onset preeclampsia using public DNA methylation data
Authors: Fernández-Boyano I. , Inkster A. M. , Yuan V. , Robinson W. P. 
Published: September 2023

Background: A growing body of literature has reported molecular and histological changes in the human placenta in association with preeclampsia (PE). Placental DNA methylation (DNAme) and transcriptomic patterns have revealed molecular subgroups of PE that are associated with placental histopathology and clinical phenotypes of the disease. However, the clinical and molecular heterogeneity of PE both across and within subtypes complicates the study of this disease. PE is most strongly associated with placental pathology and adverse fetal and maternal outcomes when it develops early in pregnancy. We focused on placentae from pregnancies affected by preeclampsia that were delivered before 34 weeks of gestation to develop eoPred, a predictor of the DNAme signature associated with the placental phenotype of early-onset preeclampsia (EOPE).Results: Public data from 83 placental samples (HM450K), consisting of 42 EOPE and 41 normotensive preterm birth (nPTB) cases, was used to develop eoPred—a supervised model that relies on a highly discriminative 45 CpG DNAme signature of EOPE in the placenta. The performance of eoPred was assessed using cross-validation (AUC = 0.95) and tested in an independent validation cohort (n = 49, AUC = 0.725). A subset of fetal growth restriction (FGR) and late-PE cases showed a similar DNAme profile at the 45 predictive CpGs, consistent with the overlap in placental pathology between these conditions. The relationship between the EOPE probability generated by eoPred and various phenotypic variables was also assessed, revealing that it is associated with gestational age, and it is not driven by cell composition differences.Conclusion: eoPred relies on a 45-CpG DNAme signature to predict a homogeneous placental phenotype of EOPE in a discrete or continuous manner. Using this classifier should 1) aid in the study of placental insufficiency and improve the consistency of future placental DNAme studies of PE, 2) facilitate identifying the placental phenotype of EOPE in public data sets and 3) importantly, standardize the placental diagnosis of EOPE to allow better cross-cohort comparisons. Lastly, classification of cases with eoPred will be useful for investigating the relationship between placental pathology and genetic or environmental variables.
Prospective assessment of pre-existing and de novo anti-HLA IgE in kidney, liver, lung and heart transplantation
Authors: Mucha Jasmin , Cho Ara , Weijler Anna Marianne , Muckenhuber Moritz , Hofmann Amun Georg , Wahrmann Markus , Heinzel Andreas , Linhart Birgit , Gattinger Pia , Valenta Rudolf , Berlakovich Gabriela , Zuckermann Andreas , Jaksch Peter , Oberbauer Rainer , Wekerle Thomas 
Published: September 2023

IntroductionAntibody mediated rejection (ABMR) is a major factor limiting outcome after organ transplantation. Anti-HLA donor-specific antibodies (DSA) of the IgG isotype are mainly responsible for ABMR. Recently DSA of the IgE isotype were demonstrated in murine models as well as in a small cohort of sensitized transplant recipients. In the present study, we aimed to determine the frequency of pre-existing and de novo anti-HLA IgE antibodies in a cohort of 105 solid organ transplant recipients.MethodsWe prospectively measured anti-HLA IgE antibodies in a cohort of kidney (n=60), liver, heart and lung (n=15 each) transplant recipients before and within one-year after transplantation, employing a single-antigen bead assay for HLA class I and class II antigens. Functional activity of anti-HLA IgE antibodies was assessed by an in vitro mediator release assay. Antibodies of the IgG1-4 subclasses and Th1 and Th2 cytokines were measured in anti-HLA IgE positive patients.ResultsPre-existing anti-HLA IgE antibodies were detected in 10% of renal recipients (including 3.3% IgE-DSA) and in 4.4% of non-renal solid organ transplant recipients (heart, liver and lung cohort). Anti-HLA IgE occurred only in patients that were positive for anti-HLA IgG, and most IgE positive patients had had a previous transplant. Only a small fraction of patients developed de novo anti-HLA IgE antibodies (1.7% of kidney recipients and 4.4% of non-renal recipients), whereas no de novo IgE-DSA was detected. IgG subclass antibodies showed a distinct pattern in patients who were positive for anti-HLA IgE. Moreover, patients with anti-HLA IgE showed elevated Th2 and also Th1 cytokine levels. Serum from IgE positive recipients led to degranulation of basophils in vitro, demonstrating functionality of anti-HLA IgE.DiscussionThese data demonstrate that anti-HLA IgE antibodies occur at low frequency in kidney, liver, heart and lung transplant recipients. Anti-HLA IgE development is associated with sensitization at the IgG level, in particular through previous transplants and distinct IgG subclasses. Taken together, HLA specific IgE sensitization is a new phenomenon in solid organ transplant recipients whose potential relevance for allograft injury requires further investigation.
RETRACTED: Macrophages depletion alleviates lung injury by modulating AKT3/GXP4 following ventilator associated pneumonia
Authors: Zhu Youfeng , Chen Yang , Xie Di , Xia Dong , Kuang Huanming , Guo Xinmin , Ning Bo 
Published: September 2023

BackgroundAKT3 appears to play a role in lung cancer. However, its role in ventilator-associated pneumonia is still unclear. Therefore, this study aimed to investigate the role of AKT3 in macrophages during ventilator-associated pneumonia.MethodsThe mRNA level of AKT3, Data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), The data is analyzed using the Xiantao academic analysis tool. Additionally, the roles of AKT3 in ventilator-associated pneumonia (VAP) were investigated through in vivo experiments.ResultsAKT3 was differentially expressed in various normal and tumor tissues. Functional enrichment analysis indicated the immunomodulatory function and inflammatory response of AKT3 in lung cancer. Depletion of macrophages protected against lung epithelial cells and significantly decreased MMP9, MMP19, FTH, and FTL expression levels and increased GPX4 expression levels, while partially reversing the changes in macrophage. Mechanistically, macrophage depletion attenuates ferroptosis of lung epithelial cells by modulating AKT3 following VAP.ConclusionCollectively, this study suggests the need for further validation of the immunoregulatory function of AKT3 in lung cancer. Additionally, macrophage depletion mitigates lung injury by modulating the AKT3/GPX4 pathway in the context of VAP.