bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single‐immittance‐network‐based inductive‐power‐transfer systems for driving multistring lighting‐emmiting diodes with current balance
Authors: Huang Zhenwei , Huang Zhicong 
Published: January 2023

SummaryMultistring arrays of LED in parallel connection are widely applied in lighting fields. Active control and passive methods are utilized to guarantee equal current sharing between different strings with a common voltage source. Compared with active control, the passive methods that adopt purely passive components without real power dissipation are good candidates. Currently, an inductive power transfer (IPT) converter providing a constant voltage (CV) line, followed by some immittance networks that convert the CV line to constant current (CC) outputs, is commonly used to drive multiple LED strings. However, in such a two‐conversion‐stage scheme, the component count is as many as
, where
is the number of LED strings, which deviates from compact, low‐cost, and simple design ideas. To address it, this paper aims to develop a single‐immittance‐network‐based IPT system to drive multistring LEDs with the current balance. The proposed IPT system can directly provide a CV to CC conversion to drive multistring LEDs with the benefits of simplifying the circuit design, size, and cost. The proposed IPT system also features programmable luminous power, zero‐phase‐angle (ZPA) input, IPT technology, and load‐independent‐current (LIC) output. Detailed analysis, implementation, and experiment are presented in this paper.
An improved robust coupled sliding mode control strategy for solar photovoltaic‐based single‐phase inverters
Authors: S Sanal Kumar , S Palanivel , MS Kamalesh 
Published: January 2023

SummarySolar photovoltaic (SPV)‐based single‐phase inverters are universally accepted and commercially utilized renewable power converter system. Generally, the magnitude of the inverter output is perturbed on load variations, and the intermediate DC‐DC boost converter output is perturbed because of the solar availability. The main intermediary component is the DC‐Link capacitor. The regulation of DC‐Link voltage is the key factor in maintaining the stability of the system with bilateral power converters. In the existing methods, individual Sliding Mode Control (SMC) are used to maintain the stability of the converters independently. However, the individual SMC's do not have any corelated control to address the common problem of DC‐Link voltage regulation. This paper proposes an alternative solution with Coupled SMC (CSMC) to address the problem of regulating the DC‐Link voltage. Both the Boost‐SMC and Inverter‐SMC are individually developed and controlled in a unified approach by having mutual adjustments in the converter and inverter switching pulses. The CSMC strategy is developed in Matlab and experimented using dSPACE‐MicrolabBox. The validation tests are compared with conventional SMC, which shows the betterment of CSMC in robustness and waveshape tracking.
Microbial degradation products of lurasidone and their significance in postmortem toxicology
Authors: Castle Jared W. , Butzbach Danielle M. , Walker G. Stewart , Lenehan Claire E. , Reith Frank , Costello Samuel P. , Kirkbride K. Paul 
Published: January 2023

AbstractRecent research reported that lurasidone degrades in unpreserved ante‐mortem human whole blood inoculated with microorganisms known to dominate postmortem blood specimens. In vitro degradation occurred at a similar rate to risperidone, known to degrade in authentic postmortem specimens until below analytical detection limits. To identify the lurasidone degradation products formed, an Agilent 6520 liquid chromatograph quadrupole‐time‐of‐flight mass spectrometer (LC‐QTOF‐MS) operating in auto‐MS/MS mode was used. Numerous degradation products not previously reported in prior in vitro or in vivo pharmacokinetic studies or forced degradation studies were detected. Accurate mass data, mass fragmentation data, acetylation experiments, and a proposed mechanism of degradation analogous to risperidone supports initial identification of the major degradation product as N‐debenzisothiazole‐lurasidone (calculated m/z [M + H]+ = 360.2646). A standard was unavailable to conclusively confirm this identification. Retrospective data analysis of postmortem cases involving lurasidone identified the presence of the major degradation product in four of six cases where lurasidone was also detected. This finding is significant for toxicology laboratories screening for this drug in postmortem casework. The major postmortem lurasidone degradation product has consequently been added to the LC‐QTOF‐MS drug screen at Forensic Science SA (FSSA) to indicate postmortem lurasidone degradation in authentic postmortem blood specimens and as a marker of lurasidone administration in the event lurasidone is degraded to concentrations below detection limits.
Determinants of departure to natal dispersal across an elevational gradient in a long‐lived raptor species
Authors: Scherler Patrick , Witczak Stephanie , Aebischer Adrian , van Bergen Valentijn , Catitti Benedetta , Grüebler Martin U. 
Published: January 2023

AbstractAttributes of natal habitat often affect early stages of natal dispersal. Thus, environmental gradients at mountain slopes are expected to result in gradients of dispersal behavior and to drive elevational differences in dispersal distances and settlement behavior. However, covariation of environmental factors across elevational gradients complicates the identification of mechanisms underlying the elevational patterns in dispersal behavior. Assuming a decreasing food availability with elevation, we conducted a food supplementation experiment of red kite (Milvus milvus) broods across an elevational gradient toward the upper range margin and we GPS‐tagged nestlings to assess their start of dispersal. While considering timing of breeding and breeding density across elevation, this allowed disentangling effects of elevational food gradients from co‐varying environmental gradients on the age at departure from the natal home range. We found an effect of food supplementation on age at departure, but no elevational gradient in the effect of food supplementation. Similarly, we found an effect of breeding density on departure age without an underlying elevational gradient. Supplementary‐fed juveniles and females in high breeding densities departed at younger age than control juveniles and males in low breeding densities. We only found an elevational gradient in the timing of breeding. Late hatched juveniles, and thus individuals at high elevation, departed at earlier age compared to early hatched juveniles. We conclude that favorable natal food conditions, allow for a young departure age of juvenile red kites. We show that the elevational delay in breeding is compensated by premature departure resulting in an elevational gradient in departure age. Thus, elevational differences in dispersal behaviour likely arise due to climatic factors affecting timing of breeding. However, the results also suggest that spatial differences in food availability and breeding density affect dispersal behavior and that their large‐scale gradients within the distributional range might result in differential natal dispersal patterns.
Reading the signs: Camera‐trapping provides new insights on scent marking in the large‐antlered muntjac (Muntiacus vuquangensis)
Authors: Tilker Andrew , Sinovas Pablo 
Published: January 2023

AbstractWe present evidence of scent marking in the large‐antlered muntjac (Muntiacus vuquangensis). Given the importance of scent marking in individual recognition among ungulates, this behavior may serve to communicate the fitness cost of antagonistic interactions among rival males and could serve as a mechanism for mate assessment among females.
Domestication provides durum wheat with protection from locust herbivory
Authors: Chapuis Marie‐Pierre , Leménager Nicolas , Piou Cyril , Roumet Pierre , Marche Héloïse , Centanni Julia , Estienne Christophe , Ecarnot Martin , Vasseur François , Violle Cyrille , Kazakou Elena 
Published: January 2023

AbstractLower plant resistance to herbivores following domestication has been suggested as the main cause for higher feeding damage in crops than in wild progenitors. While herbivore compensatory feeding has also been proposed as a possible mechanism for raised damage in crops with low nutritional quality, predictions regarding the effects of plant domestication on nutritional quality for herbivores remain unclear. In particular, data on primary metabolites, even major macronutrients, measured in the organs consumed by herbivores, are scarce. In this study, we used a collection of 10 accessions of wild ancestors and 10 accessions of modern progenies of Triticum turgidum to examine whether feeding damage and selectivity by nymphs of Locusta migratoria primarily depended on five leaf traits related to structural resistance or nutrient profiles. Our results unexpectedly showed that locusts favored wild ancestors over domesticated accessions and that leaf toughness and nitrogen and soluble protein contents increased with the domestication process. Furthermore, the quantitative relationship between soluble protein and digestible carbohydrates was found to poorly meet the specific requirements of the herbivore, in all wheat accessions, both wild and modern. The increase in leaf structural resistance to herbivores in domesticated tetraploid wheat accessions suggested that resource allocation trade‐offs between growth and herbivory resistance may have been disrupted by domestication in the vegetative organs of this species. Since domestication did not result in a loss of nutritional quality in the leaves of the tetraploid wheat, our results rather provides evidence for a role of the content of plants in nonnutritive nitrogenous secondary compounds, possibly deterrent or toxic, at least for grasshopper herbivores.
TPN10466 ameliorates Concanavalin A‐induced autoimmune hepatitis in mice via inhibiting ERK/JNK/p38 signaling pathway
Authors: Liu Guangyu , Zhang Yan , Han Sansheng , Zhuang Wei , Lv Jie , Han Mengyao , Xie Ling , Jiang Xiangrui , Wang Chun , Saimaier Kaidireya , Shen Jingshan , Du Changsheng 
Published: January 2023

AbstractAutoimmune hepatitis (AIH) eventually progresses to liver fibrosis, cirrhosis, and even hepatocellular carcinoma, causing irreversible damage to the liver. Concanavalin A‐induced hepatitis in mice is a well‐established model with pathophysiology similar to that of immune‐mediated liver injury in human viral and autoimmune hepatitis, and it has been widely used to explore the pathogenesis and clinical treatment of human immune hepatitis. Artemisinin has been shown to exhibit anti‐inflammatory effects through unclear mechanisms. In this study, we aimed to assess the effect of the artemisinin derivative TPN10466 on AIH. In vitro studies showed that TPN10466 dose dependently inhibited the percentage of IFN‐γ‐producing T cells. Further studies showed that TPN10466 attenuated the disease severity of AIH by downregulating the ability of lymphocytes to secrete IFN‐γ and by reducing lymphocyte number in the liver. In addition, we found that TPN10466 treatment reduced T‐cell responses by inhibiting JNK, ERK, and p38 pathways. In conclusion, our work suggests that TPN10466 provides protection against the autoimmune disease AIH by suppressing the inflammatory response of T cells, suggesting that TPN10466 may be a promising potential agent for the treatment of AIH.
Investigation of Cobalt(III) Cage Complexes as Inhibitors of the Mitochondrial Calcium Uniporter
Authors: Bigham Nicholas P. , Wilson Justin J. 
Published: January 2023

AbstractThe mitochondrial calcium uniporter (MCU) mediates uptake of calcium ions (Ca2+) into the mitochondria, a process that is vital for maintaining normal cellular function. Inhibitors of the MCU, the most promising of which are dinuclear ruthenium coordination compounds, have found use as both therapeutic agents and tools for studying the importance of this ion channel. In this study, six Co3+ cage compounds with sarcophagine‐like ligands were assessed for their abilities to inhibit MCU‐mediated mitochondrial Ca2+ uptake. These complexes were synthesized and characterized according to literature procedures and then investigated in cellular systems for their MCU‐inhibitory activities. Among these six compounds, [Co(sen)]3+ (3, sen=5‐(4‐amino‐2‐azabutyl)‐5‐methyl‐3,7‐diaza‐1,9‐nonanediamine) was identified to be a potent MCU inhibitor, with IC50 values of inhibition of 160 and 180 nM in permeabilized HeLa and HEK293T cells, respectively. Furthermore, the cellular uptake of compound 3 was determined, revealing moderate accumulation in cells. Most notably, 3 was demonstrated to operate in intact cells as an MCU inhibitor. Collectively, this work presents the viability of using cobalt coordination complexes as MCU inhibitors, providing a new direction for researchers to investigate.
O‐Acylative Vinylation of Cyclodextrin‐Based [3]Rotaxane Towards Rotaxane Crosslinkers
Authors: Akae Yosuke , Takata Toshikazu 
Published: January 2023

AbstractThe acylation of a cyclodextrin‐based [3]rotaxane was implemented with anhydride reagents following a facile procedure. Methacrylic anhydride facilitated the introduction of a vinyl‐group into the rotaxane structure toward achieving a crosslinker. Interestingly, only a few methacrylic units were attached to the cyclodextrin at reaction temperatures of up to 60 °C even with an excess amount of the reagent, probably due to steric hindrance. Therefore, the number of vinyl groups on the [3]rotaxane framework was easily controlled to be approximately two units via a simple random acylation, which worked effectively as a facile synthesis route for the rotaxane crosslinker. The acylation behavior was investigated in detail by NMR and MALDI‐TOF‐MS analyses. Such a proposed approach will help overcome the trade‐off between convenience and utility associated with the mono‐modification of cyclodextrins.
An electrochemical sensor based on octahedral composite modified glassy carbon electrode for voltammetric detection of cocaine
Authors: Oveili Elham , Jahani Shohreh , Tayari Omid , Jahanara Abbas , Fazli Zohreh , Aramesh‐Boroujeni Zahra , Rashidi Soroush , Baravati Nadia Rezaei Zade , Foroughi Mohammad Mehdi 
Published: January 2023

AbstractThe current work aimed to fabricate a new cocaine sensor of octahedral palladium‐doped cobaltite composite (Oh‐Pd2+ : Co3O4‐C) using a simple hydrothermal protocol. As‐fabricated cocaine sensing approach was validated by various methods. Energy dispersive X‐ray analysis, X‐ray diffraction and scanning electron microscopy were recruited to characterize our charged modified composite. The electrode could sensitively detect cocaine, with a lengthy linear range (0.01 μM–900.0 μM) and a limit of detection (1.3 nM). The quantitative cocaine determination was achieved in the biological specimens using our modified electrode, the results of which displayed admirable outcomes.
Controlled Growth of Hybrid Halide Perovskites by Crown Ether Complexation for Perovskite Solar Cells
Authors: Kim Sun-Ju , Kumar Chitumalla Ramesh , Kim Jong‐Min , Jang Joonkyung , Oh Jin‐Woo , Milić Jovana V. , Seo Ji‐Youn 
Published: January 2023

AbstractHost‐guest complexation has demonstrated potential for controlling hybrid organic‐inorganic metal halide perovskite materials. In particular, crown ethers have been used due to their capacity to interact with metal cations (e. g., Pb2+) and small organic cations (e. g., methylammonium (MA)), which can affect hybrid perovskite materials and their solar cells. However, this strategy has been underexploited in perovskite photovoltaics, and the underlying mechanisms are not well understood. In this study, we investigate the influence of 15‐crown‐5 (15C5) and its benzannulated derivative (benzo‐15‐crown‐5, B15C5), as well as amino‐functionalized analogues (15‐crown‐5)‐2‐methylamine, 2A‐15C5, and 4′‐aminobenzo‐15‐crown‐5, 4A‐B15C5, on MAPbI3 perovskite crystallization and inverted solar cell performance. We demonstrate the propensity of crown ether modulators to interact with Pb2+ cations at the perovskite interface by density functional theory calculations. This has been shown to facilitate oriented crystal growth and homogeneous film formation, as revealed by X‐ray diffraction analysis complemented by scanning electron microscopy. As a result, we demonstrate an increase in the power conversion efficiency of the solar cells of interest to advancing hybrid photovoltaics.
From ancient Egypt to the dermatologic office: An overview of skin substitutes and modern‐day applications in dermatologic surgery
Authors: Tran Alison , Desai Sahira , Mraz Robinson Deanne 
Published: January 2023

AbstractSkin grafting (specifically xenografting) dates back to as early as 1500 before Christ (BC) in the Ebers papyrus, an Egyptian medical papyrus. In 1503, the use of human skin allograft was described in the manuscript of Branca of Sicily, and among the Hindu Tilemaker Caste approximately 2500–3000 years ago, surgeons repaired defects secondary to nose amputations of those who committed adultery and thievery. Over the years, many advancements in skin grafts/substitutes and their applications have propelled the field to focus on better graft survival, contracture prevention, cosmesis, and quality of life. We provide a general overview of skin substitutes (SS) with a particular focus on placental SS and their current applications in dermatologic surgery.
The epigenetic regulator BRD4 is required for myofibroblast differentiation of knee fibroblasts
Authors: Dudakovic Amel , Bayram Banu , Bettencourt Jacob W. , Limberg Afton K. , Galvan M. Lizeth , Carrasco Margarita E. , Stans Britta , Thaler Roman , Morrey Mark E. , Sanchez‐Sotelo Joaquin , Berry Daniel J. , van Wijnen Andre J. , Abdel Matthew P. 
Published: January 2023

AbstractArthrofibrosis, which is characterized by excessive scar tissue and limited motion, can complicate the daily functioning of patients after total knee arthroplasty (TKA). Molecular hallmarks of arthrofibrosis include pathologic accumulation of myofibroblasts and disproportionate collagen deposition. Epigenetic mechanisms, including posttranslation modification of histones, control gene expression and may regulate fibrotic events. This study assessed the role of the bromodomain and extra‐terminal (BET) proteins on myofibroblast differentiation. This group of epigenetic regulators recognize acetylated lysines and are targeted by a class of drugs known as BET inhibitors. RNA‐seq analysis revealed robust mRNA expression of three BET members (BRD2, BRD3, and BRD4) while the fourth member (BRDT) is not expressed in primary TKA knee outgrowth fibroblasts. RT‐qPCR and western blot analyses revealed that BET inhibition with the small molecule JQ1 impairs TGFβ1‐induced expression of ACTA2, a key myofibroblast marker, in primary outgrowth knee fibroblasts. Similarly, JQ1 administration also reduced COL3A1 mRNA levels and collagen deposition as monitored by picrosirius red staining. Interestingly, the inhibitory effects of JQ1 on ACTA2 mRNA and protein expression, as well as COL3A1 expression and collagen deposition, were paralleled by siRNA‐mediated depletion of BRD4. Together, these data reveal that BRD4‐mediated epigenetic events support TGFβ1‐mediated myofibroblast differentiation and collagen deposition as seen in arthrofibrosis. To our knowledge, these are the first studies that assess epigenetic regulators and their downstream events in the context of arthrofibrosis. Future studies may reveal clinical utility for drugs that target epigenetic pathways, specifically BET proteins, in the prevention and treatment of arthrofibrosis.
Esterase D interacts with metallothionein 2A and inhibits the migration of A549 lung cancer cells in vitro
Authors: Yao Wen , Chen Xinpeng , Cui Xiaoling , Zhou Bangzhao , Zhao Baoxiang , Lin ZhaoMin , Miao Junying 
Published: January 2023

AbstractEsterase D (ESD) is a nonspecific esterase widely distributed in various organisms. ESD plays an important role in regulating cholesterol efflux, inhibiting viral replication and lung cancer growth. MT2A (metallothionein 2A) is the most important isoform of metallothionein (MTs) in human and high expression of MT2A in tumors represents poor prognosis and metastatic behavior. However, there are no reports about the molecular mechanism of ESD in the regulation of tumor metastasis. In this study, we found for the first time that activation ESD promoted its interaction with MT2A and decreased the protein level of MT2A, which resulting in the concentration of free zinc ions up‐regulated, and inhibited the migration of A549 lung cancer cells in vitro.
Machine‐learning assisted scheduling optimization and its application in quantum chemical calculations
Authors: Ma Yingjin , Li ZhiYing , Chen Xin , Ding Bowen , Li Ning , Lu Teng , Zhang Baohua , Suo BingBing , Jin Zhong 
Published: January 2023

AbstractEasy and effective usage of computational resources is crucial for scientific calculations, both from the perspectives of timeliness and economic efficiency. This work proposes a bi‐level optimization framework to optimize the computational sequences. Machine‐learning (ML) assisted static load‐balancing, and different dynamic load‐balancing algorithms can be integrated. Consequently, the computational and scheduling engine of the ParaEngineis developed to invoke optimized quantum chemical (QC) calculations. Illustrated benchmark calculations include high‐throughput drug suit, solvent model, P38 protein, and SARS‐CoV‐2 systems. The results show that the usage rate of given computational resources for high throughput and large‐scale fragmentation QC calculations can primarily profit, and faster accomplishing computational tasks can be expected when employing high‐performance computing (HPC) clusters.
Detection of Hg2+ with NBD‐based colorimetric chemosensor: Practical application to water samples and test strips
Authors: Jung Sumin , Moon Sungjin , Kim Cheal 
Published: January 2023

AbstractA new nitrobenzoxadiazole (NBD)‐based chemosensor N′‐(7‐nitrobenzo[c][1,2,5]oxadiazol‐4‐yl)thiophene‐2‐carbohydrazide (NTCH) was synthesized for detecting Hg2+. NTCH could sense Hg2+ through a color change method from pale yellow to pink. Binding ratio of NTCH and Hg2+ was determined to be 1:1 with the analysis of electrospray ionization mass spectrometry and Job plot. Detection limit turned out to be 0.69 μM. In addition, NTCH could be successfully utilized for detecting Hg2+ in real water samples and visible color test strips. The probing mechanism of NTCH to Hg2+ was explained with 1H nuclear magnetic resonance (NMR) titration, Job plot, electrospray ionization mass spectrometry (ESI‐MS), and theoretical calculations.