bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal assessment of anxiety and depression symptoms in U.S. adolescents across six months of the coronavirus pandemic
Authors: Bowen Anne E. , Wesley Katherine L. , Cooper Emily H. , Meier Maxene , Kaar Jill L. , Simon Stacey L. 
Published: December 2022

Abstract
Background
The present study aimed to describe anxiety and depression symptoms at two timepoints during the coronavirus pandemic and evaluate demographic predictors.

Methods
U.S. high school students 13–19 years old completed a self-report online survey in May 2020 and November 2020-January 2021. The Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Depression and Anxiety short forms queried depression and anxiety symptoms.

Results
The final sample consisted of 694 participants (87% White, 67% female, 16.2 ± 1.1 years). Nearly 40% of participants reported a pre-pandemic depression diagnosis and 49% reported a pre-pandemic anxiety diagnosis. Negative affect, defined as both moderate to severe depression and anxiety PROMIS scores, was found in ~ 45% of participants at both timepoints. Female and other gender identities and higher community distress score were associated with more depression and anxiety symptoms. Depression symptoms T-score decreased slightly (− 1.3, p-value  ≤ 0.001).

Conclusion
Adolescent mental health screening and treatment should be a priority as the pandemic continues to impact the lives of youth.
Three-dimensional characteristics of temporomandibular joint morphology and condylar movement in patients with mandibular asymmetry
Authors: Tun Oo Lin , Miyamoto Jun J. , Takada Jun-Ichi , Cheng Shih-Wei Eric , Yoshizawa Hideyuki , Moriyama Keiji 
Published: December 2022

Abstract
Background
Investigating the morphological and functional effects on mandibular asymmetry (MA) is important not only to understand the developmental process of masticatory dysfunction, but also to provide suggestions for evidence-based occlusal treatment.

Aim
To evaluate three-dimensional temporomandibular joint (TMJ) morphology and its relationship to asymmetrical condylar movement in MA patients.

Materials and methods
Fifty subjects were divided into MA and control groups (n = 25 each) according to a menton deviation of 4 mm from the mid-sagittal plane. TMJ morphology (condyle, glenoid fossa and TMJ spaces) were evaluated using a three-dimensional analysis programme. Three-dimensional condylar movements (from the sagittal and horizontal planes) were recorded and measured by computerized axiography on protrusion. Side-to-side asymmetry was measured for each parameter. The asymmetry index value was calculated to assess the correlation between TMJ morphology and condylar movement. For the statistical analysis, Wilcoxon’s signed-ranked test, the Mann–Whitney U test, and Spearman’s rank correlation were used.

Results
Glenoid fossa volume, surface area, anteroposterior length, and condylar volume were significantly smaller, and articular eminence angle, glenoid fossa, and condylar axial angle were significantly larger, on the shifted side of the MA group when compared with those on the non-shifted side and the mean values of the control group (P < 0.05). The TMJ spaces of the MA group showed no bilateral difference but were significantly narrower in the medial, superior, and anterior joint spaces when compared with the control group (P < 0.05). Condylar path length and sagittal condylar inclination were significantly asymmetrical. The asymmetry index of the condyle volume was significantly correlated with that of the condylar path length (P = 0.005). The asymmetry index of the glenoid fossa volume and the articular eminence angle were significantly correlated with that of the sagittal condylar inclination (P = 0.009 and P = 0.002, respectively), and the asymmetry index of glenoid fossa volume was significantly correlated with the bilateral transverse condylar inclination (P = 0.006 and P = 0.016, respectively).

Conclusions
Morphological asymmetry of the TMJ is significantly different between the shifted and non-shifted sides and is closely related to functional asymmetry of condylar movement in MA patients. (350/350).
Infantile Kaposiform hemangioendothelioma in a female patient complicated with severe obstructed jaundice: a case report
Authors: Watanabe Eiichiro , Hashizume Naoki , Yoneda Akihiro , Kasahara Mureo , Ozeki Genta , Saito Takeshi , Fujiogi Michimasa , Kano Motohiro , Yamamoto Yuki , Miyazaki Osamu , Maekawa Takanobu , Nakano Noriyuki , Yoshioka Takako , Fujino Akihiro , Kanamori Yutaka 
Published: December 2022

Abstract
Background
Kaposiform hemangioendothelioma (KHE) is a rare locally aggressive vascular neoplasm that occurs mainly in the pediatric population. KHE usually originates just underneath the skin and affects deeper tissues through infiltrative growth; however, visceral tissue involvement is quite rare.

Case presentation
An 8-month-old girl with jaundice and acholic stool was referred to our hospital for further evaluation of a hepatoduodenal ligament tumor. A blood examination revealed high bilirubin and liver enzyme levels, but no signs of coagulopathy. The first attempt at a diagnostic surgical procedure did not provide sufficient diagnostic information. However, the histopathological diagnosis of the cystic duct excised in the second surgery indicated KHE. Therefore, in our case, KHE was considered a cause of obstructive jaundice. Sirolimus (rapamycin) was initiated, and the patient was discharged 7 months after admission.

Conclusions
In cases of atypical hypervascular lesions in the abdominal cavity, especially in the pediatric population, it is important to consider the possibility of KHE, and surgical intervention with proper strategies is required for diagnosis, followed sequentially by promising treatments.
Tongue laceration in a patient taking antiplatelet agents during transcranial motor-evoked potential monitoring: a case report
Authors: Matsumoto Katsuhiro , Nakagawa Hideyuki , Kitamura Akira 
Published: December 2022

Abstract
Background
Transcranial motor-evoked potential (Tc-MEP) monitoring is usually performed during surgeries involving a risk of damaging brain motor areas. However, it involves a risk of bite injuries. We report a case of severe tongue laceration from Tc-MEP stimulation during carotid endarterectomy (CEA) in a patient taking antiplatelet agents.

Case presentation
A 74-year-old man on antiplatelet therapy was scheduled for CEA under general anesthesia with intraoperative Tc-MEP monitoring. Bite blocks were not inserted. Postoperatively, we observed a tongue laceration with severe bleeding, which was sutured. The difficulties in tongue movement persisted for ≥ 1 month postoperatively.

Conclusions
Bite injuries during Tc-MEP may induce severe bleeding in patients on antiplatelets. The complications of tongue bite injuries may persist, decreasing the patients’ quality of life. Hence, during Tc-MEP monitoring, it is important to use soft bite blocks and to check the patient’s face and the position of the tracheal tube intraoperatively.
Maternal stress experiences with neonatal intensive care unit admissions
Authors: Ansari Tazeem Fatima , Wade Poonam , Singh Vinaya , Malik Sushma 
Published: December 2022

AbstractBackgroundMother experiences variety of stressors related to premature birth, baby’s medical condition, unpleasant neonatal intensive care unit (NICU) environment and intuit liability of the infant. Identifying factors that causes stress may be useful in assisting health personnel in understanding their importance and in improving the quality of care. Objective of the study is to assess the stress levels of mothers whose neonate is admitted to the NICU as measured by Parental Stress Scale: Neonatal Intensive Care Unit (PSS: NICU).MethodsThis prospective analytical study was conducted in NICU of a tertiary care hospital over a period of 12 months after obtaining permission from the institutional ethics committee. The self-administered questionnaire comprising questions on: sights and sounds experienced in NICU, baby’s looks and behaviour, parental role and relationship with her baby were collected. The mean score and standard deviation were calculated for each component of PSS: NICU Scale and mean scores are compared.ResultsMothers having full term babies have experienced more stress than those having pre-term babies. As measured by PSS-NICU scale the highest mean scores of 2.3 ± 0.57, 4.36 ± 0.53, 4.43 ± 0.58 were obtained for questions “The other sick babies in the room” component of Sight and Sound, “Seeing my baby looking sick” Component of Looks and Behaviour, “Being separated from my baby” Component of Parental Role and Relationship respectively.ConclusionPresent study summarises the overall impact of NICU environmental stressors affecting mothers in a developing country and also emphasises the need for further studies in this area for identification of factors that contribute to maternal stress. It may enable health professionals to facilitate mothers’ adaptation, thereby promoting optimal mother–infant relationships and subsequent infant development.
Adrenal Steroids and Resistance to Hormonal Blockade of Prostate and Breast Cancer
Authors: Michael Patrick , Roversi Gustavo , Brown Kristy , Sharifi Nima 
Published: December 2022

Abstract
Prostate cancer and breast cancer are sex-steroid–dependent diseases that are driven in major part by gonadal sex steroids. Testosterone (T) is converted to 5α-dihydrotestosterone, both of which stimulate the androgen receptor (AR) and prostate cancer progression. Estradiol is the major stimulus for estrogen receptor-α (ERα) and proliferation of ERα-expressing breast cancer. However, the human adrenal provides an alternative source for sex steroids. A number of different androgens are produced by the adrenals, the most abundant of which is dehydroepiandrosterone (DHEA) and DHEA sulfate. These precursor steroids are subject to metabolism by peripherally expressed enzymes that are responsible for the synthesis of potent androgens and estrogens. In the case of prostate cancer, the regulation of one of these enzymatic steps occurs at least in part by way of a germline-encoded missense in 3β-hydroxysteroid dehydrogenase-1 (3βHSD1), which regulates potent androgen biosynthesis and clinical outcomes in men with advanced prostate cancer treated with gonadal T deprivation. The sex steroids that drive prostate cancer and breast cancer require a common set of enzymes for their generation. However, the pathways diverge once 3-keto, Δ4-androgens are generated and these steroids are either turned into potent androgens by steroid-5α-reductase, or into estrogens by aromatase. Alternative steroid receptors have also emerged as disease- and treatment-resistance modifiers, including a role for AR in breast cancer and glucocorticoid receptor both in breast and prostate cancer. In this review, we integrate the commonalities of adrenal steroid physiology that regulate both prostate and breast cancer while recognizing the clear distinctions between these diseases.
A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing
Authors: Avari Parizad , Eng Pei Chia , Hu Ming , Chen Runzhi , Popovic Natalija , Polychronakos Constantin , Spalding Duncan , Rutter Guy A , Oliver Nick , Wernig Florian 
Published: December 2022

Abstract

Context
Prohormone convertase 1/3 (PC1/3), encoded by protein convertase subtilisin kexin type 1 (PCSK1), converts inactive prohormones into biologically active peptides. Somatic mutations of insulinomas are associated with genetic defects interfering with control of insulin secretion from pancreatic beta cells. However, somatic mutations in proinsulinomas have not been described.

Objective
We report a case of a proinsulinoma, with suppressed insulin and C-peptide levels.

Methods
A 70-year-old woman presented with a 20-year history of “blackouts.” During a 72-hour fast, blood glucose level dropped to 1.9 mmol/L with suppressed plasma insulin and C-peptide levels, but proinsulin levels were raised at 37 pmol/L (&lt;10 pmol/L).

Results
Imaging revealed 3 distinct DOTATATE-avid pancreatic lesions. Laparoscopic spleen-preserving distal pancreatomy was performed. In view of discordant insulin, C-peptide, and proinsulin levels, whole exome sequencing analysis was performed on the tumor. In the somatic exome of the tumor, we found mutations in PCSK expression regulators, as well as a novel truncating somatic mutation in ATP6V0D1, a subunit of the ion pump that acidifies the β-cell compartments where the PCSKs act.

Conclusion
Appropriately suppressed insulin levels in the context of hypoglycemia do not always indicate the absence of a neuroendocrine islet cell tumor and proinsulin levels may be indicated to solidify the diagnosis. In the context of elevated proinsulin levels, low insulin and C-peptide levels might be explained by somatic mutations that likely implicate proinsulin processing within the tumor. Furthermore, we propose several mechanistic candidates, including ATP6V0D1. Experimental validation using cellular approaches may in future confirm pathomechanisms involved in this rare condition.
Factors influencing decision making on donating organs for transplantation in the opinion of the respondents - study using the CAWI method
Authors: Majchrowicz Bożena 
Published: December 2022

Introduction: Organ transplantation is a procedure of transferring living cells, tissues or organs within one organism or between two organisms. Despite the great achievements of transplantology and the legal basis regulating organ and tissue procurement and transplantation, there are still difficulties in overcoming social and psychological resistance related to this method of treatment and related to granting consent for organ donation.
The aim of the study was to determine the knowledge of the factors influencing the decision to transplant organs among the respondents.
Material and methods: The study was conducted using the CAWI method, where invitations were sent to a randomly selected group of respondents on the basis of specialized mailing lists, the research tool was a self-designed questionnaire. Participation in the study was anonymous and voluntary.
Results and conclusions: Respondents have knowledge about transplantation. 52.4% of the respondents would agree that all organs should be taken from them after death in order to save the lives of other people, the remaining group was against it. The acceptance of organ donation may have an impact on the development of transplantology, especially thanks to its understanding by families who have to make decisions in this regard.
Polynomial Upper Bounds on the Number of Differing Columns of Δ-Modular Integer Programs
Authors: Lee Jon , Paat Joseph , Stallknecht Ingo , Xu Luze 
Published: December 2022

We study integer-valued matrices with bounded determinants. Such matrices appear in the theory of integer programs (IPs) with bounded determinants. For example, an IP can be solved in strongly polynomial time if the constraint matrix is bimodular: that is, the determinants are bounded in absolute value by two. Determinants are also used to bound the [Formula: see text] distance between IP solutions and solutions of its linear relaxation. One of the first to quantify the complexity of IPs with bounded determinants was Heller, who identified the maximum number of differing columns in a totally unimodular matrix. Each extension of Heller’s bound to general determinants has been superpolynomial in the determinants or the number of equations. We provide the first column bound that is polynomial in both values. For integer programs with box constraints, our result gives the first [Formula: see text] distance bound that is polynomial in the determinants and the number of equations. Our result can also be used to derive a bound on the height of Graver basis elements that is polynomial in the determinants and the number of equations. Furthermore, we show a tight bound on the number of differing columns in a bimodular matrix; this is the first tight bound since Heller. Our analysis reveals combinatorial properties of bimodular IPs that may be of independent interest. Funding: J. Lee was supported in part by the Office of Naval Research [Grant N00014-21-1-2135] and the Air Force Office of Scientific Research [Grant FA9550-19-1-0175]. J. Paat was supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant [Grant RGPIN-2021-02475].
Assessing and managing open fractures: a systematic approach
Authors: Davies Monica , Dorrell Victoria , Grainger Charlotte , Ahluwalia Ashish , Vasireddy Aswin , Ahluwalia Raju 
Published: December 2022

Open fractures are complex injuries strongly associated with high-energy trauma. Assessment should include the mechanism and place of injury, timing, associated injuries and comorbidities. The initial management of these fractures, whether in the prehospital setting or emergency department, must include the following in a prompt manner: administration of antibiotics and tetanus prophylaxis, photography, reduction or re-alignment, wound coverage and splintage. Imaging includes plain X-rays and a computed tomography trauma scan, as well as an angiogram if vessel damage is suspected. Collectively, the energy of the mechanism of injury, with the level of contamination, potential for compartment syndrome and vascular damage, determines the operative urgency. Operative management can be a one- or two-stage procedure, because definitive internal skeletal fixation should only be attempted if soft tissue coverage can occur during the same operation. Ideally, all open fractures should be closed within 72 hours. This article explores the evidence for current best practice.
Anticoagulation for Patients Undergoing Implantation of a Cardiac Implantable Electronic Device
Authors: Llewellyn Jennifer , Ezeonwumelu Chinenyenwa , Jackson Lynsey , Rao Archana 
Published: December 2022

Aims/background The number of cardiac devices implanted increases year on year, as does the complexity of the patients being managed. A large proportion of this patient group have an indication for anticoagulation, and this raises challenges around the perioperative management of these agents. Method A quality improvement project was conducted to review current practice, understand local experience and improve patient care. Results Following the initial review, local guidelines were updated, the postoperative anticoagulation decision escalated to the responsible clinician and a clearer pathway for communicating the decision created. Conclusions The implemented changes have shown an overall improvement in junior doctor feedback and also clinical documentation in the electronic patient records.
Prevalence and Correlates of Self-Injury among Adolescents: A Cross-Sectional Study
Authors: Domingues Priscila Naves , Da Silva Tatiana Fonseca 
Published: December 2022

Introduction: Non-suicidal self-injury (NSSI) is defined as a deliberate and voluntary self-inflicted physical damage without suicidal intent. However, the risk of suicide is significantly higher among those who have previously engaged in NSSI. Adolescents are at risk for developing this type of behavior, as elevated levels of impulsivity and emotional reactivity are present due to brain developmental processes.
Methods: A cross-sectional survey that collected data from a sample of 140 adolescents from two Brazilian public schools in august of 2018. The prevalence of self-injury was calculated, and related factors were analyzed, such as sex, socioeconomic status, age of onset, recurrence, intention to die and healthcare assistance.
Results: The prevalence of self-injury was 25% (n = 35) in the sample. Girls were seven times more likely to practice self-injury than boys (OR 7.42; 95% CI 2.80-19.66; p<0.001). However, boys were more likely to have intention to die, recurrence, absence of pain, and no healthcare assistance. The age of onset was 13 to 15 years for most cases. More than one third of participants reported multiple episodes of self-injury (five episodes or more) and they were 13 times more likely to have intention to die (OR 13.2; 95% CI 1.44-120.69; p=0.010). Only one person reported using medication on a daily basis (selective serotonin reuptake inhibitor) and 28.6% reported undergoing professional healthcare assistance.
Conclusion: Self-injury is a prevalent behavior in adolescents, that potentially results in psychological and physical impairments. Further research to achieve a better understanding of clinical and epidemiological features of self-injury is essential so that more effective preventive and therapeutic interventions can be developed to target the needs of young people worldwide.
Study of the Difference Between Centric Occlusion and Retruded Contact Position
Authors: Polasek Antonia , Plisko Manuela , Profozic Anja , Plazibat Antonia , Cimic Samir 
Published: December 2022

Purpose: The aim of this study was to investigate the difference between retruded contact position (RCP) and centric occlusion (CO) at the level of mandibular condyles.
Materials and methods: Study included 20 completely dentate participants (average 24.4 ± 1.2 years). All recordings of the condylar deviations were measured with the use of the ultrasound mandibular recording device with six degrees of freedom. CO was determined using active method of centric relation recording (participants were trained to stationary hinge and maintain the position of the lower jaw at the first tooth contact/contacts). RCP was determined with passive method of centric relation recording (chin point guidance). RCP and CO deviations to the reference position (habitual occlusion) were recorded with the use of the mandibular recording device at the level of x (anterior – posterior), y (vertical) and z (lateral) axes. Linear RCP and CO deviations (from the habitual occlusion) were measured. Descriptive statistics was measured, and the RCP and CO deviation values were compared using independent samples T test.
Results: Average linear condylar deviation values for the CO were 1.30 ± 1.14 mm, and 2.13 ± 1.89 mm for the RCP. Independent samples T test showed statistically significant difference between RCP and CO linear deviation values (α=0.021).
Conclusions: There is a difference in the positioning of the condyle within temporomandibular joint, with passive or active centric relation recording methods. CO and RCP can be identified as different occlusal positions.
Editorial
Authors: Iizuka Edson Sadao 
Published: December 2022

Prezados leitores e leitoras,
Desde a sua criação, em meados dos anos 2000, o periódico mantinha a mesma estrutura e governança. No segundo semestre de 2022, em função dos avanços e a própria maturidade do periódico, implementamos as seguintes mudanças: implementamos a co-edição científica, sendo o Prof. Diógenes Bido o primeiro a ocupar essa posição; remodelamos o Conselho Editorial com a presença de novos membros: Prof. Alexandre Gracioso (ESPM), Prof. Antonio de Araujo Freitas Junior (FGV), Profª Eda Coutinho Barbosa Machado de Souza (IESB), Prof. Edson Kenji Kondo (FGV), Prof. Edison Simoni (FECAP), Prof. Flávio Vasconcelos (FGV), Prof. Irineu Gustavo Nogueira Gianesi (Insper) e Profª Priscila Borin de Oliveira Claro (Insper). No início de 2023, será formado um novo Conselho Científico. Finalmente, cabe mencionar o Conselho Honorário destinado aos que atuaram nos primórdios da revista como forma de reconhecimento aos nossos fundadores.