bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Zinc Supplementation on Duration of Hospital Stay in Childhood Pneumonia
Authors: Ahmed ATM Faruque , Hyder Rumy Tabrez , Sufian Abu , Hossain Abir , Majumder Ripon Chundra 
Published: June 2023

Background: Pneumonia is one of the major causes of death in children younger than age five, especially in developing countries. Supplementation with zinc is effective in the treatment and prevention of childhood pneumonia.
Objective: To assess the duration of hospitalization after zinc supplementation in childhood pneumonia.
Materials and Methods: This randomized double blind controlled trial was conducted in the Department of Pediatrics, Sylhet MAG Osmani Medical College Hospital, Sylhet during the period from 1st July 2013 to 30th June 2015. A total of 120 patients with severe pneumonia in hospitalized children fulfilling inclusion and exclusion criteria were enrolled by systematic random sampling. Group allocation of Group-A and Group-B was done by lottery method each consisting of 60 and 60 patients. Identically small packets that contained 10mg zinc sulphate powder or 10 mg placebo powder were coded as A and B by guide.
Results: Time for normalization of all parameters (clinical recovery) in placebo group and zinc group was 127.12±24.58 hours and 111.23±35.47 hours respectively which were statistically significant (p<0.05). All patients of both groups were discharged. The mean duration of hospital stay was found to be 6.78±0.42 days in placebo group and 5.42±0.81 days in zinc group. Mean duration of hospital stay was significantly less in zinc group in comparison to placebo (p<0.05).
Conclusion: Supplementation of zinc therapy in childhood pneumonia causes early clinical recovery and less duration of hospital stay in comparison to the non-zinc therapy group.
Eastern Med Coll J. Jan 2023; 8 (1) 15-18
Periodontal Status and Gingival Conditions of the Tea Workers
Authors: Bhowmick Anjan , Nurunnabi Mohammad , Adhikary Laboni , Rahman Md Shamsur , Saha Tanmoy , Hossain Kazi Jahangir 
Published: June 2023

Background: Periodontitis and gingivitis are prevalent chronic inflammatory diseases. The examination of the periodontal and gingival conditions is complex and requires a proficient dental healthcare provider to detect the patient’s definite problems.
Methodology: The study was designed as a cross-sectional study to assess the periodontal status and gingival conditions of the 372 tea workers in the purposively selected Premnagar tea garden located in Moulvibazar district, Sylhet 3200, Bangladesh. ‘Community Periodontal Index’ (CPI) was used to measure the periodontal status.
Results: Most of the workers (38.2%) were from the age group ≥37 years and illiterates (62.1%). More than two-fourths (57.8%) had detected calculus during probing, one-fourth (25.3%) had a shallow pocket and only 11.6% had healthy periodontal status. The prevalence of poor periodontal status was 88.4%. Among the dental cleaning aids such as toothbrush users, 15.6% had healthy periodontal status, whereas the smokeless tobacco non-users (22.6%) and pan-supari non-chewers (75.0%) had healthy periodontal conditions. The level of periodontal status factors was statistically significant with age, educational qualification, and monthly household income (p<0.05) of the workers.
Conclusion: The study warrants poor periodontal health status among the tea workers. It is essential to do the periodical assessment of the periodontal condition, risk factors analysis, and management complications by establishing dental health corners in tea garden health settings.
Eastern Med Coll J. Jan 2023; 8 (1) 19-23
TRANSITION OF ONLINE SINGLE SUBMISSION (OSS 1.1 TO RISK-BASED APPROACH) TO INCREASE INVESTMENT IN WEST SUMATERA
Authors: Anggunsuri Upita , Zahara Zahara 
Published: June 2023

The implementation of an online single submission risk-based approach (OSS RBA) is a manifestation of a government program to increase investment in a region. Business risk classification is an instrument of the Central Government and Local Government in controlling business activity. This study aims to find out the readiness of the local government to implement an online single submission risk-based approach. The method of the study is empirical legal research. The result of this study shows that Padang City has issued Mayor Regulation No 43 /2021 on Guidelines and Procedures of an online single submission risk-based approach Supervision as a follow-up to Government Regulation No. 5/2021 on implementation of online single submission risk-based approach; meanwhile, several other regions are in the process of drafting local regulations relate to implementing online single submission risk-based approach in West Sumatera Province. The challenges of local government to implement OSS RBA consists of indefinite license periods in the particular business field (Appendix I Government Regulation No 5/2021), the regional support system has not integrated OSS RBA and the readiness for the transition from manual RDTR to digital RDTR in West Sumatera.
Local art museums and visitors: audience and attendance development. Theoretical requirements and empirical evidence
Authors: Cerquetti Mara 
Published: June 2023

During the 20th century museum visitor studies have used different approaches with varying results. They have covered not only individual demographic and psychographic characteristics, but also the motivation, needs and expectations of both visitors and non-visitors. According to the visitor-oriented approach, most research has suggested to attract and satisfy new audiences promoting social interaction and the emotional involvement of visitors through edutainment, new technological devices, exhibitions and other ‘block-buster’ events.In this paper we will analyse the content and language of art museum communication, to verify if the general knowledge people have when they visit a museum is sufficient to understand and appreciate the complex value of exhibits in museums and if museum communication strategies are suitable to the mise en valeur of local cultural heritage. Analysing the findings of a local survey on the relationship between museums and their real and potential visitors, carried out among students, the following paper argues that museums and education should enhance the distinctive features of local cultural heritage, both to promote the understanding of its complex value and to reach new audiences.
Sevoflurane inhibited reproductive function in male mice by reducing oxidative phosphorylation through inducing iron deficiency
Authors: Zhang Xue , Zuo Yong , Zhang Jianhua , Zhang Di , Naeem Muhammad , Chang Yanzhong , Shi Zhenhua 
Published: June 2023

Sevoflurane (Sev) is one of the commonly used inhalation anesthetic chemicals in clinics. It has great impact on spermatogenesis and fertilization in male animals. The underlying mechanism remains largely unexplored. Based on our previous research, we hypothesized that Sev induced iron metabolism disturbance in the testis and epididymis and inhibited the spermatogenesis. In this study, two-month-old C57BL/6 male mice were treated with 3% Sev for 6 h, and their fertility (including sperm concentration, sperm mobility, and the number of offspring) was evaluated. Mice testis, epididymis, and sperm were harvested and subjected to Western blot analysis and immunofluorescence analysis. Iron levels were reflected by the gene expression of iron metabolism-related proteins (including ferritin, TfR1, and FpN1) and ICP-MS and Perl’s iron staining. Electron transport and oxidative phosphorylation levels were measured by Oxygraph-2k and ATP contents. The activity of ribonucleotide reductase was evaluated by assay kit. DNA synthesis status in testis and/or epididymis was marked with BrdU. Cell proliferation was evaluated by double immunofluorescence staining of specific protein marker expression. Our results revealed that the mice exposed to Sev showed damaged testicular and epididymis structure and significantly reduced the sperm concentration, sperm motility, and fertility. Sev decreases the iron levels through down-regulating the expression of H-ferritin, L-ferritin, and FpN1, and up-regulating the expression of TfR1 in the testis and epididymis. Iron levels also significantly reduced in germ cells which decrease the number of germ cells, including sperm, Sertoli cells, and primary spermatocyte. Iron deficiency not only decreases electron transport, oxidative phosphorylation level, and ATP production but also suppresses the activity of ribonucleotide reductase and the expression of Ki67, DDX4, GATA1, and SCP3, indicating that Sev affects the spermatogenesis and development. Meanwhile, Sev impaired the blood-testis barrier by decreasing the ZO1 expression in the testis and epididymis. The damage effect induced by Sev can be significantly ameliorated by iron supplementation. In conclusion, our study illustrates a new mechanism by which Sev inhibits spermatogenesis and fertility through an oxidative phosphorylation pathway due to iron deficiency of epididymis and testis or sperm. Furthermore, the damaging effects could be ameliorated by iron supplementation.
The Sedimentary records of the Hapcheon impact crater basin in Korea over the past 1.3 Ma
Authors: Lee Jin-Young , Shin Seungwon , Yoon Hyun Ho , Kim Jin Cheul , Choi Yire , Nahm Wook-Hyun , Kim Heejung 
Published: June 2023

The Hapcheon impact crater is the only meteorite impact crater identified on the Korean peninsula. However, the morphology of the impact crater and the nature of the meteorite collision are unknown. In this study, we analyzed the sedimentary facies using grain size data; computed tomography images, 14C, 10Be, and optically stimulated luminescence dating on a &gt;66-m-long sediment core (20HCL04) recovered from the Hapcheon Basin. Four sedimentary units and 10 types of facies were documented in the Hapcheon Basin sediment core. The sedimentary units comprise 1) a lower part (unit 1) that is dominated by moderately to well-sorted coarse gravel, which contains some impact-related sediments; 2) a middle part (units 2 and 3) dominated by well-laminated mud; and 3) an upper part (Unit 4) that is dominated by poorly sorted coarse gravel supplied from the surrounding mountain slopes by alluvial and fluvial processes. After the meteorite impact, the Hapcheon impact crater was filled with deposits from the crater wall after ca. 1.3 Ma and the Hapcheon Basin became a deep lake environment. After ca. 0.5 Ma, sediments were supplied from the surrounding mountains until the lake was filled. Finally, sediments were deposited in an alluvial fan setting. In addition, the Hapcheon Basin sedimentary cores contain a tephra layer and deformed soft sediments that can be used to investigate volcanic and seismic events on the Korean Peninsula over the past 1.3 Ma.
Precipitation-type discrimination and changes in related climate indices in the upper Heihe River Basin during 1960–2021
Authors: Wang Guanxing , Zhang Fan , Wang Li , Zeng Chen , Shi Xiaonan , Xiao Xiong 
Published: June 2023

Introduction: Precipitation in the upstream region of the Heihe River basin (UHRB) in the northeastern of the Tibetan Plateau, which is the main water source of the basin, has undergone drastic changes in extreme climate events in recent decades. In addition to the amount of precipitation, the type of precipitation has a substantial impact on hydrological processes.Methods: In this study, we compared the results from three methods aimed at improving precipitation type estimation based on daily precipitation type records for 24 discontinuous years. Based on the precipitation type distinction, we examined the spatial and temporal changes in the total precipitation, rainfall, snowfall and air temperature at the six stations as well as the spatial average of the UHRB during the past 62 years. We also analyzed changes in the quantity, duration magnitude, and frequency of extreme precipitation using the RClimDex model and statistical analysis.Results: The probability of detection value of the T3.6_4.5 method was 1.9%, indicating the estimation was closest to actual records. The analyses based on precipitation type diving showed that rainfall accounts for an average of 81.9% of the total precipitation received in a year. In the context of large scale climate warming, temperatures at all six stations increased significantly, but precipitation changes were only apparent at about half of the stations which were located in regions of higher elevation and influenced by both ENSO and the East Asian monsoon. Analysis of the spatial averages in the UHRB revealed that the annual drought events (CDD) were significantly alleviated, and that the growing season length (GSL) was significantly extended. The annual total precipitation, rainfall, and extreme precipitation indices (P99P, P95P, R95P, and SDII) increased in magnitude, and the frequency of extreme precipitation events (P10mm) also significantly increased.Discussion: The findings of this study indicate that under the background of climate warming, the changes of precipitation patterns in the UHRB which may have resulted in bringing better vegetation growth, but also the increasingly frequent extreme rainfall events may pose challenges to growing extreme rainfall events to agriculture and other human activities in local and downstream areas.
Whole exome sequencing identified five novel variants in CNTN2, CARS2, ARSA, and CLCN4 leading to epilepsy in consanguineous families
Authors: Abdulkareem Angham Abdulrhman , Zaman Qaiser , Khan Hamza , Khan Sabar , Rehman Gauhar , Tariq Nabeel , Ahmad Mashal , Owais Muhammad , Najumuddin  , Muthaffar Osama Yousef , Bibi Fehmida , Khang Rin , Ryu Seung Woo , Naseer Muhammad Imran , Jelani Musharraf 
Published: June 2023

Introduction: Epilepsy is a group of neurological disorders characterized by recurring seizures and fits. The Epilepsy genes can be classified into four distinct groups, based on involvement of these genes in different pathways leading to Epilepsy as a phenotype. Genetically the disease has been associated with various pathways, leading to pure epilepsy-related disorders caused by CNTN2 variations, or involving physical or systemic issues along with epilepsy caused by CARS2 and ARSA, or developed by genes that are putatively involved in epilepsy lead by CLCN4 variations.Methods: In this study, five families of Pakistani origin (EP-01, EP-02, EP-04, EP-09, and EP-11) were included for molecular diagnosis.Results: Clinical presentations of these patients included neurological symptoms such as delayed development, seizures, regression, myoclonic epilepsy, progressive spastic tetraparesis, vision and hearing impairment, speech problems, muscle fibrillation, tremors, and cognitive decline. Whole exome sequencing in index patients and Sanger sequencing in all available individuals in each family identified four novel homozygous variants in genes CARS2: c.655G&gt;A p.Ala219Thr (EP-01), ARSA: c.338T&gt;C: p.Leu113Pro (EP-02), c.938G&gt;T p.Arg313Leu (EP-11), CNTN2: c.1699G&gt;T p.Glu567Ter (EP-04), and one novel hemizygous variant in gene CLCN4: c.2167C&gt;T p.Arg723Trp (EP-09).Conclusion: To the best of our knowledge these variants were novel and had not been reported in familial epilepsy. These variants were absent in 200 ethnically matched healthy control chromosomes. Three dimensional protein analyses revealed drastic changes in the normal functions of the variant proteins. Furthermore, these variants were designated as “pathogenic” as per guidelines of American College of Medical Genetics 2015. Due to overlapping phenotypes, among the patients, clinical subtyping was not possible. However, whole exome sequencing successfully pinpointed the molecular diagnosis which could be helpful for better management of these patients. Therefore, we recommend that exome sequencing be performed as a first-line molecular diagnostic test in familial cases.
Utilization of waste wind turbine blades in performance improvement of asphalt mixture
Authors: Lan Tianhui , Wang Bingze , Zhang Junchao , Wei Hao , Liu Xu 
Published: June 2023

Redundant wind turbine blades (WTBs) retired from wind power facilities produce substantial waste annually and induce challenging environmental problems. As the most widely used materials for high-grade pavement construction, asphalt mixtures must have excellent high- and low-temperature performance, as well as water damage resistance, since pavement is subjected to complex loading, temperature, and humidity changes. This study proposed an asphalt mixture with the addition of two types of recycled WTB (rWTB): rWTB powders of granular sizes below 0.075 mm and rWTB fibers in the size range of 0.075–9.5 mm. First, the thermogravimetric analysis results indicated the accepted thermal stability of rWTB material for the requirement of compaction, paving, and service condition of asphalt mixtures. Second, the properties of the asphalt mixtures modified by using (i) rWTB powder (5 wt%, 10 wt%, and 15 wt% in fine filler), (ii) rWTB fiber (0.1 wt%, 0.2 wt% and 0.3 wt% in fine aggregate), and (iii) both rWTB powder and fiber were investigated by wheel tracking tests at 60°C, three-point bending tests at −10°C, and Marshall immersion tests. The experimental results showed that the rWTB asphalt mixtures could improve the overall road performance of asphalt mixtures, and that an optimal pavement performance could be obtained by the synergistic addition of rWTB powder and fiber. In addition, it was indicated that the improving mechanism of the rWTB material on the asphalt mixture was mainly attributed to its good compatibility with the asphalt binder, allowing the rWTB to strengthen asphalt mortar and improve the high- and low-temperature performance of the asphalt mixture.
Research trends from 1992 to 2022 of acupuncture anesthesia: a bibliometric analysis
Authors: Sun Linxi , Wei Xuqiang , Wang Ke , Zhou Jia 
Published: June 2023

BackgroundAcupuncture anesthesia is a significant technical development that originated in China in 1958 and was introduced to the West in the early 1970s. Due to its relative novelty, it has been the subject of intense scrutiny and contestation. Since the early 1970s, the use of acupuncture as a complementary treatment for opioid analgesics has been accepted. Research on acupuncture anesthesia has helped to reduce clinical opioid abuse. However, only a few articles have focused on previous publications that reflect the trend of the study, the main investigators, reciprocal collaboration, and other information in this field. In view of this, we utilized bibliographic analysis methods to objectively analyze current trends and research hotspots in this field, aiming to provide a foundation and reference for future studies.MethodsThe Web of Science database was searched for publications related to acupuncture anesthesia between 1992 and 2022. The CiteSpace and VOSviewer were used to analyze the annual publications, authors, Co-cited authors, and their countries (regions) and institutions, co-occurrence keywords, burst keywords, Co-citation references and Co-citation journals.ResultsA total of 746 eligible publications were retrieved from the database for the analysis, including 637 articles and 109 reviews. And the trend of annual publications continued to grow. Aashish J. Kumar, Daniel I. Sessler, Baoguo Wang, and Paul F. White published the most papers in this field (7), and all authors, had a very low centrality (&lt;0.01). China (252) and the University of California System (21) were the most productive country (region) and institution, respectively, while the United States (0.62) and University of California System (0.16) had the highest centrality. After removing keywords related to the search strategy, the three most frequent were pain (115), electroacupuncture (109), and stimulation (91). The six most recent burst keywords were recovery, transcutaneous electrical acupoint stimulation, systematic review, quality, general anesthesia, and surgery. Wang et al.’s article had the highest co-citation count (20), whereas Zhang et al.’s articles had the highest centrality (0.25). The Journal of Anesthesia and Analgesia was the most influential one (408 co-citations).ConclusionThis research provides valuable information for the study of acupuncture anesthesia. In recent years, frontier topics in acupuncture anesthesia research have been the promotion of perioperative rehabilitation, anesthesia management, and quality improvement.
Malignancy in dermatomyositis: a mono-centric retrospective study of 134 patients in China and a potential predictive model
Authors: Tang Zhuang-Li , Chi Chao-cheng , Tang Zhen-Wei , Li Xia-Wei , Man Xiao-Yong 
Published: June 2023

ObjectivesTo describe the demographics and phenotypes of malignancies-associated dermatomyositis (MADM) in east China and pinpoint potential factors indicative of malignancies in patients with dermatomyositis and establish a predictive model.MethodsWe retrospectively analyzed clinical data from 134 patients with adult-onset dermatomyositis hospitalized between January 2019 and May 2022 in one comprehensive hospital. Clinical data including disease course, initial symptoms and signs, and demographic information were retrieved from the Electronic Medical Records System. Other parameters including myositis-specific autoantibodies profiles, ferritin, sedimentation, etc. were all referable. Multivariable multinomial logistic regression was employed to simulate a model to predict cancer risks. Receiver operating characteristic curve was adopted to evaluate the potency of the model.Results134 patients with adult-onset dermatomyositis were aptly enrolled in this study based on inclusive and exclusive criteria: 12 (8.96%) with malignancies, 57 (42.53%) with aberrant tumor biomarkers but no malignancies, 65 (48.51%) with neither malignancies nor abnormal tumor biomarkers. Senior diagnostic age, higher LDH, higher ferritin, positive anti-TIF1γ and anti-Mi2 rather than anti-NXP2 autoantibodies were positive indicators of malignancies. Additionally, neither initial complaints nor signs were found to be correlated to a tendency towards malignancies. Digestive system, nasopharyngeal, and lung malignancies were mostly documented in east China. One multivariable multinomial logistic regression model was established to predict the phenotypes of dermatomyositis on the basis of potential malignancies and the overall sensitivity and specificity was satisfactory.ConclusionPositivity of anti-TIF1γ and anti-Mi2 autoantibodies are highly indicative of malignancies while the role of anti-NXP2 autoantibody in MADM in the Chinese population remains unclear. The phenotypes of malignancies can be predicted through the model and the predictive power is sufficient. More attention should be paid to malignancies screening in patients with aberrant tumor biomarkers but no malignancies, particularly digestive system, nasopharyngeal, and lung malignancies in patients with dermatomyositis but without malignancies.