bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the home care service: a remote inpatient service for people requiring mental health care
Authors: Doyle Caroline , King Marie , Kirwan Shane , Jennings Bernie , Farrington Aoife , Keogh Brian , Donohue Gráinne 
Published: August 2023

Background/Aims In response to the COVID-19 pandemic, St Patrick's Mental Health Services introduced a home care package, offering all the elements of the inpatient programmes, but provided to the service user remotely in their own home. A survey was used to evaluate service user experiences of receiving remote inpatient mental health treatment via the home care service. Methods All participants who had a virtual admission were invited to complete a quantitative survey online. Data were inputted into the Statistical Package for Social Sciences software and a descriptive analysis was completed. Results A total of 88 participants completed the online survey, the majority of whom were women (62.5%) and between the ages of 61 and 70 years (28.4%). Diagnosis was most often depression (60.2%) or anxiety (29.4%) and almost 66% of participants had previous inpatient experience. Staff rated most highly by participants were the consultant psychiatrist (96.7%), ward-based nursing staff (95.2%) and their psychologist (92.3%). The highest rating statements, which participants rated as part of a questionnaire, were around technology options (87.1%), one-to-one work with a clinician (81.3%) and arranging collection of medicine (81%). Conclusions Preliminary scores on this survey demonstrate that remote care is an effective way to improve access, enhance quality and provide efficient care. Further research should consider clinical outcomes with this model compared to standard care.
Compact and wideband multiport plasmonic coupler–splitter based on coding metamaterials
Authors: Yu Shuai , Liu Zunwei , Dai Jian , Zhang Tian , Xu Kun 
Published: August 2023

We propose plasmonic coupler–splitters based on embedded coding metamaterials. The fundamental transverse electric mode in a silicon waveguide is coupled to the surface plasmon polariton mode in plasmonic waveguides with high efficiency of nearly 95% and wide bandwidth of 1.45–1.65 µm, and then light is split into different output ports. To improve the performance of the devices, a multi-objective optimization scheme based on the non-dominated sorting genetic algorithm-II assisted by the direct-binary search method is applied in the design of coding metamaterials. The simulated results exhibit that utilizing our inverse design scheme, the plasmonic coupler–splitter can perform effective plasmonic coupling (total coupling efficiencies of more than 92%) and high-quality power splitting with various split ratios (split ratio errors lower than 1%) and output directions at a broad bandwidth (1.45–1.65 µm) simultaneously. The function of the frequency split can also be implemented in the same universal basic scheme. In comparison to previous works, we not only propose flexible coupler–splitter designs for various functions based on a universal design scheme, but also introduce effective algorithms for the inverse design of optical devices based on coding metamaterials.
Multiple anthropometric measures and proarrhythmic 12-lead ECG indices: A mendelian randomization study
Authors: Ardissino Maddalena , Patel Kiran Haresh Kumar , Rayes Bilal , Reddy Rohin K. , Mellor Greg J. , Ng Fu Siong 
Published: August 2023

Background
Observational studies suggest that electrocardiogram (ECG) indices might be influenced by obesity and other anthropometric measures, though it is difficult to infer causal relationships based on observational data due to risk of residual confounding. We utilized mendelian randomization (MR) to explore causal relevance of multiple anthropometric measures on P-wave duration (PWD), PR interval, QRS duration, and corrected QT interval (QTc).

Methods and findings
Uncorrelated (r2 < 0.001) genome-wide significant (p < 5 × 10−8) single nucleotide polymorphisms (SNPs) were extracted from genome-wide association studies (GWAS) on body mass index (BMI, n = 806,834), waist:hip ratio adjusted for BMI (aWHR, n = 697,734), height (n = 709,594), weight (n = 360,116), fat mass (n = 354,224), and fat-free mass (n = 354,808). Genetic association estimates for the outcomes were extracted from GWAS on PR interval and QRS duration (n = 180,574), PWD (n = 44,456), and QTc (n = 84,630). Data source GWAS studies were performed between 2018 and 2022 in predominantly European ancestry individuals. Inverse-variance weighted MR was used for primary analysis; weighted median MR and MR-Egger were used as sensitivity analyses. Higher genetically predicted BMI was associated with longer PWD (β 5.58; 95%CI [3.66,7.50]; p = < 0.001), as was higher fat mass (β 6.62; 95%CI [4.63,8.62]; p < 0.001), fat-free mass (β 9.16; 95%CI [6.85,11.47]; p < 0.001) height (β 4.23; 95%CI [3.16, 5.31]; p < 0.001), and weight (β 8.08; 95%CI [6.19,9.96]; p < 0.001). Finally, genetically predicted BMI was associated with longer QTc (β 3.53; 95%CI [2.63,4.43]; p < 0.001), driven by both fat mass (β 3.65; 95%CI [2.73,4.57]; p < 0.001) and fat-free mass (β 2.08; 95%CI [0.85,3.31]; p = 0.001). Additionally, genetically predicted height (β 0.98; 95%CI [0.46,1.50]; p < 0.001), weight (β 3.45; 95%CI [2.54,4.36]; p < 0.001), and aWHR (β 1.92; 95%CI [0.87,2.97]; p = < 0.001) were all associated with longer QTc. The key limitation is that due to insufficient power, we were not able to explore whether a single anthropometric measure is the primary driver of the associations observed.

Conclusions
The results of this study support a causal role of BMI on multiple ECG indices that have previously been associated with atrial and ventricular arrhythmic risk. Importantly, the results identify a role of both fat mass, fat-free mass, and height in this association.
Qualidade de uvas cv rubi revestidas com gel de Aloe vera L. na pré-colheita
Authors: Kruger Carvalho Eing Karoline , Márcia Duarte Rios Faria Cacilda , Maia Aline José , Garcia Carla , CARVALHO FELIPE , Vasconcelos Botelho Renato 
Published: August 2023

Uma das tecnologias que vem sendo estudada para a manutenção da qualidade pós-colheita de frutos é o uso de revestimentos comestíveis, que podem funcionar como uma barreira para a perda de água, alterar as trocas gasosas, além de conferir uma boa aparência ao fruto. Um dos revestimentos que vem sendo testado para esta finalidade é o Gel de Aloe vera, sendo um produto bastante rico em polissacarídeos. Neste contexto, o trabalho teve como objetivo avaliar o efeito da aplicação pré-colheita de gel de A. vera na qualidade pós-colheita de uvas cv. Rubi. Os tratamentos foram os seguintes: gel de A. vera nas doses de 100, 200, 300 mL L-1, quitosana (160 g L-1), e a testemunha (água destilada). Foram avaliadas as seguintes características pós-colheita: acidez titulável (AT), sólidos solúveis (SS), relação SS/AT, índices de coloração (Luminosidade, Hue e Croma) e teor de antocianinas. Observou-se que os revestimentos com gel de Aloe vera L. melhoraram a qualidade pós-colheita das uvas cv. Rubi, tendo reduzido a acidez titulável e aumentado a relação SS/AT, além da melhoria dos índices de coloração. Também aumentou o conteúdo de antocianinas, sendo recomendado o uso gel de Aloe vera para revestir uvas cv.
Another Way Forward: Comments on Ohlson’s Critique of Empirical Accounting Research
Authors: Breuer Matthias 
Published: August 2023

Abstract
Ohlson (2025. Empirical accounting seminars: Elephants in the room. Accounting, Economics, and Law: A Convivium 15, 1–8) laments that the evidentiary quality of empirical accounting research is low due to inappropriate methods and practices, leaving seminar attendees and readers unpersuaded by presented or published articles. He suggests that the norms of the profession prevent a public recognition and discussion of those issues, thereby sustaining the poor state of empirical accounting research. I agree that some current empirical approaches and norms seem to hamper progress toward more convincing research. I provide a practical suggestion to possibly improve the state of empirical accounting research. I caution though that even with better methods and more honest research practices, we should not expect that any individual research article can provide conclusive answers to important accounting questions. Such progress in knowledge requires a body of high-quality and independent research.
A workflow towards a strongly typed AutomationML API
Authors: Mersch Tina , Schleipen Miriam 
Published: August 2023

Abstract
Over the lifecycle of a production plant digitalization leads to a large data footprint along different software (SW) components. A digital data exchange is the fundament to support data integrity, prevent data loss and avoid duplicate work. AutomationML (AML) is a commonly accepted tool-independent format to exchange data of different domains along the lifecycle of a production plant. This contribution provides an easy-to-use workflow that empowers SW components to transform AML into a strongly typed class hierarchy which is the basis for an efficient and maintainable SW solution.
Effect of periostin on bone metabolic and autophagy factors during tooth eruption in mice
Authors: Qin Han , Cai Jun 
Published: August 2023

Abstract
This study aimed to investigate the effect of periostin (PN) on the expression of receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin (OPG), microtubule-associated protein1 light chain 3B (LC3B), and Beclin1 in mouse alveolar bone specimens and cultured osteoblasts in vitro, to preliminarily explore the role of PN and autophagy in remodeling bone metabolism during tooth eruption. Mice at 5 days of age were injected with 75 ng/mL recombinant PN protein under the periosteum for 3 consecutive days according to the standard of 1 mL/100 g/day. Then, their mandibles were removed, and the expression of bone metabolic and autophagy factors was detected by immunohistochemistry. Mouse osteoblast-like cells cultured in vitro were treated with recombinant PN at a concentration of 75 ng/mL. The changes in the aforementioned indicators were compared again by immunofluorescence and western blotting 72 h after dosing. The results of the mouse samples showed that the protein expression of RANKL, LC3B, and Beclin1 decreased, accompanied by the decrease in RANKL/OPG ratio. However, OPG protein expression increased in the dosing group. Immunofluorescence and western blotting results of osteoblasts cultured in vitro showed that the protein expression of RANKL, LC3B, Beclin1, and the RANKL/OPG ratio in the experimental group decreased, but OPG expression increased. PN may regulate alveolar bone metabolism during tooth eruption by inhibiting the RANKL/OPG ratio and autophagy, which will provide a new research perspective for further exploration of the mechanisms during tooth eruption.
Exploring temperature-resilient recycled aggregate concrete with waste rubber: An experimental and multi-objective optimization analysis
Authors: Tang Yunchao , Wang Yufei , Wu Dongxiao , Chen Mengcheng , Pang Lan , Sun Junbo , Feng Wanhui , Wang Xiangyu 
Published: August 2023

Abstract
For low-carbon sustainability, recycled rubber particles (RPs) and recycled aggregate (RA) could be used to make rubber-modified recycled aggregate concrete (RRAC). The characteristics (compressive strength and peak strain) of RRAC with various amounts of RA and RPs after heating at various temperatures were studied in this work. The results show that high temperatures significantly decreased the uniaxial compressive strength (UCS), whereas the addition of RA (e.g., 50%) and RPs (e.g., 5%) can mitigate the negative effect caused by high temperatures. The peak strain can also be improved by increasing the replacement ratios of RA and RP. Support vector regression (SVR) models were trained using a total of 120 groups of UCS and peak strain experimental datasets, and an SVR-based multi-objective optimization model was proposed. The excellent correlation coefficients (0.9772 for UCS and 0.9412 for peak strain) found to illustrate the remarkable accuracy of the SVR models. The Pareto fronts of a tri-objective mixture optimization design (UCS, strain, and cost) were successfully generated as the decision reference at varying temperature conditions. A sensitivity analysis was performed to rank the importance of the input variables where temperature was found as the most important one. In addition, the replacement ratio of RA is more important compared with that of the RP for both the UCS and strain datasets. Among the mechanical properties of concrete, compressive strength and peak strain are two key properties. This study provides guidance for the study of RRAC constitutive models under high temperatures.
Multicontinuum homogenization for Richards’ equation: The derivation and numerical experiments
Authors: Ammosov Dmitry , Stepanov Sergei , Spiridonov Denis , Li Wenyuan 
Published: August 2023

Abstract
In the present paper, the authors rigorously derive Richards’ multicontinuum model using the multicontinuum homogenization approach. This approach is based on formulating constraint cell problems and a homogenization-like expansion. We present numerical results for the two continua case with separable coefficients. First, we explore the relationships between the effective coefficients and the hydraulic conductivity. Then, we solve test problems with different contrasts to study the developed multicontinuum model.
Injecting climate finance into SME lending in Germany: Opportunities for and limitations of regional savings and cooperative banks
Authors: Flögel Franz , Schepelmann Philipp , Zademach Hans-Martin , Zörner Michael 
Published: August 2023

Abstract
Although small and medium-sized enterprises (SMEs) contribute considerably to Germany’s carbon emissions, regional savings and cooperative banks − SMEs’ most important financiers − hardly consider this aspect in lending to these businesses. However, given Germany’s commitment to climate neutrality by 2045, suitable approaches for injecting climate finance into these SME lending processes are greatly required. Against this background, the paper at hand aims to introduce the specific case of regional banks into the debate on green finance and green banking and suggest future research in this context. In discussing the state of research on the peculiarities of regional savings and cooperative banks, we outline the resulting opportunities and limitations for climate impact assessments in SME lending. We argue that while the dual bottom-line orientation of regional banks in Germany precludes them from applying simple positive or negative screenings, their in-depth knowledge about local clients and circumstances enables them to be active and engaging partners for the green transformation of SMEs. Nonetheless, we explain why developing solutions to utilise this knowledge for climate finance by integrating climate impact assessments into routine lending processes remains a particularly challenging task.
α4-Containing GABAAReceptors on DRD2 Neurons of the Nucleus Accumbens Mediate Instrumental Responding for Conditioned Reinforcers and Its Potentiation by Cocaine
Authors: Macpherson Tom , Dixon Claire I. , Robertson Jonathan , Sindarto Marsha M. , Janak Patricia H. , Belelli Delia , Lambert Jeremy J. , Stephens David N. , King Sarah L. 
Published: August 2023

AbstractExtrasynaptic GABAAreceptors (GABAARs) composed of α4, β, and δ subunits mediate GABAergic tonic inhibition and are potential molecular targets in the modulation of behavioral responses to natural and drug rewards. These GABAARs are highly expressed within the nucleus accumbens (NAc), where they influence the excitability of the medium spiny neurons. Here, we explore their role in modulating behavioral responses to food-conditioned cues and the behavior-potentiating effects of cocaine. α4-Subunit constitutive knock-out mice (α4−/−) showed higher rates of instrumental responding for reward-paired stimuli in a test of conditioned reinforcement (CRf). A similar effect was seen following viral knockdown of GABAAR α4 subunits within the NAc. Local infusion of the α4βδ-GABAAR-preferring agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol; Gaboxadol) into the NAc had no effect on responding when given alone but reduced cocaine potentiation of responding for conditioned reinforcers in wild-type, but not α4−/−mice. Finally, specific deletion of α4-subunits from dopamine D2, but not D1, receptor-expressing neurons (DRD2 and DRD1 neurons), mimicked the phenotype of the constitutive knockout, potentiating CRf responding, and blocking intra-accumbal THIP attenuation of cocaine-potentiated CRf responding. These data demonstrate that α4-GABAAR-mediated inhibition of DRD2 neurons reduces instrumental responding for a conditioned reinforcer and its potentiation by cocaine and emphasize the importance of GABAergic signaling within the NAc in mediating the effects of cocaine.
A dual role for the chromatin reader ORCA/LRWD1 in targeting the origin recognition complex to chromatin
Authors: Sahu Sumon , Ekundayo Babatunde E , Kumar Ashish , Bleichert Franziska 
Published: August 2023

AbstractEukaryotic cells use chromatin marks to regulate the initiation of DNA replication. The origin recognition complex (ORC)‐associated protein ORCA plays a critical role in heterochromatin replication in mammalian cells by recruiting the initiator ORC, but the underlying mechanisms remain unclear. Here, we report crystal and cryo‐electron microscopy structures of ORCA in complex with ORC's Orc2 subunit and nucleosomes, establishing that ORCA orchestrates ternary complex assembly by simultaneously recognizing a highly conserved peptide sequence in Orc2, nucleosomal DNA, and repressive histone trimethylation marks through an aromatic cage. Unexpectedly, binding of ORCA to nucleosomes prevents chromatin array compaction in a manner that relies on H4K20 trimethylation, a histone modification critical for heterochromatin replication. We further show that ORCA is necessary and sufficient to specifically recruit ORC into chromatin condensates marked by H4K20 trimethylation, providing a paradigm for studying replication initiation in specific chromatin contexts. Collectively, our findings support a model in which ORCA not only serves as a platform for ORC recruitment to nucleosomes bearing specific histone marks but also helps establish a local chromatin environment conducive to subsequent MCM2‐7 loading.
Analyzing Teaching Needs to Develop Digital Technology Innovation for Learning Process during the COVID-19 Outbreak
Authors: Mardiana Harisa 
Published: August 2023

This research examines the use of digital technology as an intervention plan for teaching during the COVID-19 outbreak in Indonesia. It assesses the readiness and preparedness of 103 social science lecturers from universities in Tangerang Kota to use digital technology for teaching during the pandemic. Many lecturers were reluctant to improve their abilities and skills in digital technology, and some found it challenging. The study used a quantitative and semi-structured qualitative method to analyze the application of technology and investigate lecturers' abilities and skills in using digital technology during the outbreak. The result revealed that 69 respondents were capable and skilled in developing technological innovation. The remaining 34 respondents faced difficulties and were advised to relearn the development of innovative technology for 21st-century learning. This research offers insights into the challenges and opportunities of using digital technology for teaching during a pandemic and highlights the importance of technological readiness.
Abstrak
Penelitian ini mengeksplorasi penggunaan teknologi digital sebagai rencana intervensi untuk mengajar selama pandemi COVID-19 di Indonesia. Penelitian ini menilai kesiapan dan persiapan 103 dosen ilmu sosial dari universitas di Tangerang Kota dalam menggunakan teknologi digital untuk mengajar selama pandemi. Banyak dosen yang enggan meningkatkan kemampuan dan keterampilan mereka dalam teknologi digital, dan beberapa dari mereka menganggapnya sulit. Studi ini menggunakan metode kuantitatif dan semi-terstruktur kualitatif untuk menganalisis penerapan teknologi dan menyelidiki kemampuan dan keterampilan dosen dalam menggunakan teknologi digital selama pandemi. Hasilnya menunjukkan bahwa 69 responden mampu dan terampil dalam mengembangkan inovasi teknologi. Sementara 34 responden lainnya mengalami kesulitan dan disarankan untuk mempelajari kembali pengembangan teknologi inovatif untuk pembelajaran abad ke-21. Penelitian ini memberikan wawasan tentang tantangan dan peluang penggunaan teknologi digital untuk mengajar selama pandemi serta menyoroti pentingnya kesiapan teknologi.
Evaluation of Subclinical Left Ventricular Systolic Dysfunction By Global Longitudinal Strain Using 2D Speckle Tracking Echocardiography in Angina With Normal Epicardial Coronary Arteries
Authors: Hoque Mohammed Shahidul , Ahmed Chaudhury Meshkat , Osmany Din-E-Mujahid Mohammad Faruque , Sowdagar Mohammad Nizamul Hossain , Banerjee Sajal Krishna 
Published: August 2023

Background: Global longitudinal strain (GLS), assessed by 2D speckle tracking echocardiography (2D-STE), may offer a valuable non-invasive method to assess subclinical left ventricular (LV) systolic dysfunction in patients with chest pain but normal epicardial coronary arteries. The primary objective of the study was to detect subclinical LV systolic dysfunction by GLS using 2D-STE in patients with angina with normal coronary arteries and conventional echocardiograms at baseline. Methods: This was a comparative case–control study that included patients with complaints of an ischaemic pattern of chest pain despite normal coronary arteries (cases) and healthy individuals (controls). Resting LV systolic function was assessed by transthoracic echocardiography and GLS using 2D-STE analysis. The results of all three planes in GLS (the apical four-chamber, two-chamber, and three-chamber views) were combined in a single ‘bull’s eye’ summary (agreeing with the standard 17-segment model), which presented the analysis of each segment along with a global peak systolic strain value for the LV. Results: The study included 120 participants (60 cases and 60 controls). The normal reference value of the mean GLS in the control group was −19.7 ± 1.84%. GLS assessed by 2D-STE was significantly impaired in patients with angina-like syndrome with normal epicardial coronary arteries (−18.78 ± 1.87 versus −19.7 ± 1.84%; p<0.007) compared with the control group despite preserved LV ejection fraction. In the case group, GLS reduced significantly in eight patients (13.3%) than control group. Conclusion: Patients with angina with normal epicardial coronary arteries are likely to have microvascular disease. GLS assessed by 2D-STE has the potential to improve the value of echocardiography in coronary microvascular disease detection. Despite normal LV ejection fraction, significant impairment of LV global longitudinal systolic function can differentiate a microvascular group of patients from others who have angina with normal coronaries.