bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penggunaan metode string matching pada sistem informasi mahasiswa Polinema dengan chatbot
Authors: Ardiansyah Rizky , Marya Dianthy , Novianti Atik 
Published: June 2023

Pelayanan kampus yang baik sangat penting untuk menunjang proses belajar mengajar di perguruan tinggi. Salah satu cara untuk meningkatkan pelayanan adalah dengan menggunakan chatbot. Chatbot dapat memberikan pelayanan yang cepat dan efisien kepada mahasiswa, serta membantu dalam mendapatkan informasi yang dibutuhkan. Chatbot dapat memberikan pelayanan yang efektif dan efisien dalam menyediakan informasi dan melakukan transaksi. Penggunaan chatbot juga mengurangi beban kerja petugas administrasi dan memungkinkan mereka untuk fokus pada tugas yang lebih kompleks. Meskipun demikian, perlu perbaikan dalam aspek keamanan data dan privasi. Penelitian ini bertujuan untuk menguji aplikasi chatbot pelayanan administrasi dengan menggunakan metode string matching. Pengujian dilakukan melalui beberapa tahap, termasuk pengujian fungsi, interaksi, kompatibilitas, keamanan, dan performa chatbot. Hasil pengujian menunjukkan bahwa chatbot memiliki tingkat akurasi sebesar 90% dengan metode string matching. Mayoritas mahasiswa merasa puas dengan kecepatan dan akurasi respon chatbot. Selain itu, aplikasi ini juga dianggap mudah digunakan oleh mahasiswa.
ABSTRACTCampus services are crucial for supporting the teaching and learning process in higher education institutions. One effective approach to enhance these services is through the implementation of chatbots. Chatbots provide prompt and efficient assistance to students, enabling them to easily access the necessary information. They offer an efficient and effective means of delivering services by providing accurate information and facilitating transactions. Furthermore, the utilization of chatbots alleviates the burden on administrative staff, allowing them to focus on more complex tasks. However, it is important to address and improve data security and privacy aspects. This research aims to evaluate an administrative service chatbot using the string matching method. The evaluation process encompasses assessing the chatbot's functionality, interaction capabilities, compatibility, security measures, and overall performance. The results demonstrate an impressive 90% accuracy rate achieved through the implementation of the string matching method. The majority of students’s express satisfaction with the chatbot's promptness and accuracy in providing responses. Additionally, the application is highly regarded for its user-friendly interface, as reported by the students.
Cervical cancer benefits from trabectedin combination with the β-blocker propranolol: in vitro and ex vivo evaluations in patient-derived organoids
Authors: Di Fonte Roberta , Strippoli Sabino , Garofoli Marianna , Cormio Gennaro , Serratì Simona , Loizzi Vera , Fasano Rossella , Arezzo Francesca , Volpicella Mariateresa , Derakhshani Afshin , Guida Michele , Porcelli Letizia , Azzariti Amalia 
Published: June 2023

Background: Cervical cancer (CC) is characterized by genomic alterations in DNA repair genes, which could favor treatment with agents causing DNA double-strand breaks (DSBs), such as trabectedin. Hence, we evaluated the capability of trabectedin to inhibit CC viability and used ovarian cancer (OC) models as a reference. Since chronic stress may promote gynecological cancer and may hinder the efficacy of therapy, we investigated the potential of targeting β-adrenergic receptors with propranolol to enhance trabectedin efficacy and change tumor immunogenicity.Methods: OC cell lines, Caov-3 and SK-OV-3, CC cell lines, HeLa and OV2008, and patient-derived organoids were used as study models. MTT and 3D cell viability assays were used for drug(s) IC50 determination. The analysis of apoptosis, JC-1 mitochondrial membrane depolarization, cell cycle, and protein expression was performed by flow cytometry. Cell target modulation analyses were carried out by gene expression, Western blotting, immunofluorescence, and immunocytochemistry.Results: Trabectedin reduced the proliferation of both CC and OC cell lines and notably of CC patient-derived organoids. Mechanistically, trabectedin caused DNA DSBs and S-phase cell cycle arrest. Despite DNA DSBs, cells failed the formation of nuclear RAD51 foci and underwent apoptosis. Under norepinephrine stimulation, propranolol enhanced trabectedin efficacy, further inducing apoptosis through the involvement of mitochondria, Erk1/2 activation, and the increase of inducible COX-2. Notably, trabectedin and propranolol affected the expression of PD1 in both CC and OC cell lines.Conclusion: Overall, our results show that CC is responsive to trabectedin and provide translational evidence that could benefit CC treatment options. Our study pointed out that combined treatment offset trabectedin resistance caused by β-adrenergic receptor activation in both ovarian and cervical cancer models.
Developmental exposures to common environmental contaminants, DEHP and lead, alter adult brain and blood hydroxymethylation in mice
Authors: Petroff Rebekah L. , Cavalcante Raymond G. , Colacino Justin A. , Goodrich Jaclyn M. , Jones Tamara R. , Lalancette Claudia , Morgan Rachel K. , Neier Kari , Perera Bambarendage P. U. , Rygiel Christine A. , Svoboda Laurie K. , Wang Kai , Sartor Maureen A. , Dolinoy Dana C. 
Published: June 2023

Introduction: The developing epigenome changes rapidly, potentially making it more sensitive to toxicant exposures. DNA modifications, including methylation and hydroxymethylation, are important parts of the epigenome that may be affected by environmental exposures. However, most studies do not differentiate between these two DNA modifications, possibly masking significant effects.Methods: To investigate the relationship between DNA hydroxymethylation and developmental exposure to common contaminants, a collaborative, NIEHS-sponsored consortium, TaRGET II, initiated longitudinal mouse studies of developmental exposure to human-relevant levels of the phthalate plasticizer di(2-ethylhexyl) phthalate (DEHP), and the metal lead (Pb). Exposures to 25 mg DEHP/kg of food (approximately 5 mg DEHP/kg body weight) or 32 ppm Pb-acetate in drinking water were administered to nulliparous adult female mice. Exposure began 2 weeks before breeding and continued throughout pregnancy and lactation, until offspring were 21 days old. At 5 months, perinatally exposed offspring blood and cortex tissue were collected, for a total of 25 male mice and 17 female mice (n = 5–7 per tissue and exposure). DNA was extracted and hydroxymethylation was measured using hydroxymethylated DNA immunoprecipitation sequencing (hMeDIP-seq). Differential peak and pathway analysis was conducted comparing across exposure groups, tissue types, and animal sex, using an FDR cutoff of 0.15.Results: DEHP-exposed females had two genomic regions with lower hydroxymethylation in blood and no differences in cortex hydroxymethylation. For DEHP-exposed males, ten regions in blood (six higher and four lower) and 246 regions (242 higher and four lower) and four pathways in cortex were identified. Pb-exposed females had no statistically significant differences in blood or cortex hydroxymethylation compared to controls. Pb-exposed males, however, had 385 regions (all higher) and six pathways altered in cortex, but no differential hydroxymethylation was identified in blood.Discussion: Overall, perinatal exposure to human-relevant levels of two common toxicants showed differences in adult DNA hydroxymethylation that was specific to sex, exposure type, and tissue, but male cortex was most susceptible to hydroxymethylation differences by exposure. Future assessments should focus on understanding if these findings indicate potential biomarkers of exposure or are related to functional long-term health effects.
High-pressure synthesis of dysprosium carbides
Authors: Akbar Fariia Iasmin , Aslandukova Alena , Aslandukov Andrey , Yin Yuqing , Trybel Florian , Khandarkhaeva Saiana , Fedotenko Timofey , Laniel Dominique , Bykov Maxim , Bykova Elena , Dubrovinskaia Natalia , Dubrovinsky Leonid 
Published: June 2023

Chemical reactions between dysprosium and carbon were studied in laser-heated diamond anvil cells at pressures of 19, 55, and 58 GPa and temperatures of ∼2500 K. In situ single-crystal synchrotron X-ray diffraction analysis of the reaction products revealed the formation of novel dysprosium carbides, Dy4C3 and Dy3C2, and dysprosium sesquicarbide Dy2C3 previously known only at ambient conditions. The structure of Dy4C3 was found to be closely related to that of dysprosium sesquicarbide Dy2C3 with the Pu2C3-type structure. Ab initio calculations reproduce well crystal structures of all synthesized phases and predict their compressional behavior in agreement with our experimental data. Our work gives evidence that high-pressure synthesis conditions enrich the chemistry of rare earth metal carbides.
On the relationship between rhythm-based temporal expectations and endogenous spatial attention in simple reaction-time tasks
Authors: Charras Pom , Chica Ana B. , Capizzi Mariagrazia 
Published: June 2023

IntroductionRecent evidence suggests that the temporal expectations afforded by a regular rhythmic structure operate independently from endogenous spatial attention in simple reaction-time tasks. The most common manipulation followed in previous studies consisted of presenting a target stimulus either “in-time” or “out-of-time” (earlier or later) with a preceding rhythm. However, contrary to the proposal of entrainment models predicting a behavioral advantage for in-time compared to both early and late targets, responses were still faster for late targets, according to the so-called “foreperiod effect”. This finding makes it difficult to fully disentangle the impact of rhythm and the benefits afforded by the passage of time on the relationship between rhythm-based temporal and endogenous spatial attention.MethodsTo shed more light on this issue, we combined a spatial orienting task with a rhythmic manipulation, in which two placeholders flanking the fixation cross flickered at either a regular or irregular pace. Spatial orienting to the target location was deployed by symbolic color cues that were displayed independently of the rhythm (independent cues) or were integrated with the temporal rhythmic cues (integrated cues). Crucially, for both independent and integrated cues, and for regular and irregular rhythms, the interval between the rhythm and the target (i.e., the foreperiod) was kept fixed in Experiments 1–3 to control for the foreperiod effect, while the effect of foreperiod was explored in Experiment 4.ResultsResults showed a more beneficial effect of rhythms with independent cues as compared to integrated cues. Additionally, the benefit of rhythms was slightly but significantly larger at valid, compared to invalid, spatial locations, regardless of the foreperiod.DiscussionOur results extend previous studies by showing that interactive effects of rhythms and endogenous spatial attention may emerge in low-demanding detection tasks.
Effects of ranolazine on right ventricular function, fluid dynamics, and metabolism in patients with precapillary pulmonary hypertension: insights from a longitudinal, randomized, double-blinded, placebo controlled, multicenter study
Authors: Han Q. Joyce , Forfia Paul , Vaidya Anjali , Ramani Gautam , deKemp Robert A. , Mach Robert H. , Mankoff David A. , Bravo Paco E. , DiCarli Marcelo , Chan Stephen Y. , Waxman Aaron B. , Han Yuchi 
Published: June 2023

IntroductionRight ventricular (RV) function is a major determinant of outcome in patients with precapillary pulmonary hypertension (PH). We studied the effect of ranolazine on RV function over 6 months using multi-modality imaging and biochemical markers in patients with precapillary PH (groups I, III, and IV) and RV dysfunction [CMR imaging ejection fraction (EF) &lt; 45%] in a longitudinal, randomized, double-blinded, placebo-controlled, multicenter study of ranolazine treatment.MethodsEnrolled patients were assessed using cardiac magnetic resonance (CMR) imaging,11C-acetate and18-F-FDG positron emission tomography (PET), and plasma metabolomic profiling, at baseline and at the end of treatment.ResultsTwenty-two patients were enrolled, and 15 patients completed all follow-up studies with 9 in the ranolazine arm and 6 in the placebo arm. RVEF and RV/Left ventricle (LV) mean glucose uptake were significantly improved after 6 months of treatment in the ranolazine arm. Metabolomic changes in aromatic amino acid metabolism, redox homeostasis, and bile acid metabolism were observed after ranolazine treatment, and several changes significantly correlated with changes in PET and CMR-derived fluid dynamic measurements.DiscussionRanolazine may improve RV function by altering RV metabolism in patients with precapillary PH. Larger studies are needed to confirm the beneficial effects of ranolazine.
Erectile dysfunction and associated factors among patients with diabetes attending follow-up at a public hospital, Harar, Eastern Ethiopia. A cross-sectional study design
Authors: Gobena Matebu Bekele , Abdosh Tekabe , Dheresa Merga , Dechasa Deribe Bekele 
Published: June 2023

BackgroundThe global prevalence of erectile dysfunction among patients with diabetes is high. It is the most underestimated problem but has a great physical, psychological, and social impact on the individual with the disease, family, and society in general. Thus, this study aimed to assess the magnitude of erectile dysfunction and associated factors among patients with diabetes attending follow-up at a public hospital, Harar, Eastern Ethiopia.MethodsFacility-based cross-sectional study was conducted on selected 210 adult male patients with diabetes attending follow-up at a public hospital, Harar, Eastern Ethiopia, from 1 February to 30 March 2020. Simple random sampling was used to select study participants. A pre-tested interviewer-administered structured questionnaire was used to collect the data. The data were entered to EpiData version 3.1 and exported to SPSS version 20 for analysis. Bivariate and multivariable binary logistic regression were carried out, and a P-value of &lt;0.05 was taken as statistically significant.ResultA total of 210 adult male patients with diabetes participated in the study. The overall magnitude of erectile dysfunction was 83.8%, with 26.7% suffering from mild, 37.5% mild to moderate, 29% moderate, and 6.8% severe erectile dysfunctions. Age 46–59 years [adjusted odds ratio (AOR): 2.560; 95% confidence interval (CI) (1.73, 6.53)], age ≥ 60 years [AOR: 2.9; 95% CI (1.48, 5.67)], and poor glycemic control [AOR: 2.140; 95% CI (1.9, 7.44)] were significantly associated with erectile dysfunction among patients with diabetes.ConclusionThe present study revealed a high magnitude of erectile dysfunction among population with diabetes. The age categories of 46–59 and ≥60 and having poor glycemic control were the only variables significantly associated with erectile dysfunction. Thus, routine screening and management for erectile dysfunction in patients with diabetes should be part of routine medical care particularly for adult male patients and those with poor glycemic control.
Utilization of glucagon-like peptide-1 receptor agonists in children and adolescents in China: a real-world study
Authors: Yan Yilong , Gong Ying , Jiang Meizhu , Gao Yiming , Guo Shanshan , Huo Jiping , Zhao Zhigang , Li Cao 
Published: June 2023

BackgroundGlucagon-like peptide-1 receptor agonists (GLP-1RAs) have been widely used in treating type 2 diabetes mellitus (T2DM) and obesity in adults, but scientific research about the indication in children and adolescents is scarce. The current study aims to explore the prescriptions of GLP-1RAs in children and adolescents in China and to evaluate its rationality.MethodsGLP-1RA prescriptions of children and adolescents were retrospectively obtained from the Hospital Prescription Analysis Cooperative Project. The study extracted information on patient’s demographic characteristics, monotherapy and combination therapy of GLP-1RAs, and trends in GLP-1RA usage from 2016 to 2021. The rationality of GLP-1RA prescriptions was comprehensively assessed based on the indications approved by China National Medical Products Administration (NMPA), the U.S. Food and Drug Administration (FDA), European Medicines Agency (EMA), Pharmaceuticals and Medical Devices Agency (PMDA), and published randomized controlled trials (RCTs).ResultsA total of 234 prescriptions from 46 hospitals were included, with a median age of 17 years old. The majority of patients were diagnosed with overweight/obesity or prediabetes/diabetes, accounting for 43.59% and 46.15%, respectively. There were 88 patients on GLP-1RA monotherapy. GLP-1RAs plus metformin was the most common combination therapy (38.89%). 12.39% of patients were found a co-administration with orlistat. The share of overweight/obesity prescriptions increased from 27% in 2016 to 54% in 2021, whereas prediabetes/diabetes prescriptions declined from 55% to 42%. The prescriptions were divided into appropriate and questionable groups according to the diagnosis, and the potentially questionable prescription was related to age (p = 0.017), department visited (p = 0.002), and any hospitalization (p &lt; 0.001).ConclusionsThis study described the prescribing of GLP-1RAs in children and adolescents. Our findings indicated that the utilization of GLP-1RAs has increased from 2016 to 2021. There was a strong basis for administering GLP-1RAs in overweight/obesity and prediabetes/diabetes, whereas the evidence was insufficient in other conditions. It is crucial to demand robust and sustained efforts to enhance the awareness of the safety of utilization of GLP-1RAs in children and adolescents.
Non-alcoholic fatty liver disease in a pediatric patient with heterozygous familial hypobetalipoproteinemia due to a novel APOB variant: a case report and systematic literature review
Authors: Molk Neza , Bitenc Mojca , Urlep Darja , Zerjav Tansek Mojca , Bertok Sara , Trebusak Podkrajsek Katarina , Sustar Ursa , Kovac Jernej , Battelino Tadej , Debeljak Marusa , Groselj Urh 
Published: June 2023

BackgroundFamilial hypobetalipoproteinemia (FHBL) is an autosomal semi-dominant disorder usually caused by variants in the APOB gene that frequently interferes with protein length. Clinical manifestations include malabsorption, non-alcoholic fatty liver disease, low levels of lipid-soluble vitamins, and neurological, endocrine, and hematological dysfunction.MethodsGenomic DNA was isolated from the blood samples of the pediatric patient with hypocholesterolemia and his parents and brother. Next-generation sequencing (NGS) was performed, and an expanded dyslipidemia panel was employed for genetic analysis. In addition, a systematic review of the literature on FHBL heterozygous patients was performed.Case reportGenetic investigation revealed the presence of a heterozygous variant in the APOB (NM_000384.3) gene c.6624dup[=], which changes the open reading frame and leads to early termination of translation into the p.Leu2209IlefsTer5 protein (NP_000375.3). The identified variant was not previously reported. Familial segregation analysis confirmed the variant in the mother of the subject, who also has a low level of low-density lipoprotein and non-alcoholic fatty liver disease. We have introduced therapy that includes limiting fats in the diet and adding lipid-soluble vitamins E, A, K, and D and calcium carbonate. We reported 35 individuals with APOB gene variations linked to FHBL in the systematic review.ConclusionWe have identified a novel pathogenic variant in the APOB gene causing FHBL in pediatric patients with hypocholesterolemia and fatty liver disease. This case illustrates the importance of genetic testing for dyslipidemias in patients with significant decreases in plasma cholesterol as we can avoid damaging neurological and ophthalmological effects by sufficient vitamin supplementation and regular follow-ups.
Socioeconomic status of the elderly MS population compared to the general population: a nationwide Danish matched cross-sectional study
Authors: Wandall-Holm Malthe Faurschou , Holm Rolf Pringler , Pontieri Luigi , Sellebjerg Finn , Magyari Melinda 
Published: June 2023

Introduction/objectivesMultiple sclerosis (MS) leads to physical and cognitive disability, which in turn impacts the socioeconomic status of the individual. The altered socioeconomic trajectory combined with the critical role of aging in MS progression could potentially lead to pronounced differences between MS patients and the general population. Few nations have the ability to connect long-term clinical and socioeconomic data at the individual level, and Denmark's robust population-based registries offer unique insights. This study aimed to examine the socioeconomic aspects of elderly Danish MS patients in comparison to matched controls from the general population.MethodsA nationwide population-based study in Denmark was conducted, comprising all living MS patients aged 50 years or older as of 1 January 2021. Patients were matched 1:10 based on sex, age, ethnicity, and residence with a 25% sample of the total Danish population. Demographic and clinical information was sourced from the Danish Multiple Sclerosis Registry, while socioeconomic data were derived from national population-based registries containing details on education, employment, social services, and household characteristics. Univariate comparisons between MS patients and matched controls were then carried out.ResultsThe study included 8,215 MS patients and 82,150 matched individuals, with a mean age of 63.4 years (SD: 8.9) and a 2:1 female-to-male ratio. For those aged 50–64 years, MS patients demonstrated lower educational attainment (high education: 28.3 vs. 34.4%, P &lt; 0.001) and fewer received income from employment (46.0 vs. 78.9%, P &lt; 0.001), and working individuals had a lower annual income (48,500 vs. 53,500€, P &lt; 0.001) in comparison to the controls. Additionally, MS patients within this age group were more likely to receive publicly funded practical assistance (14.3 vs. 1.6%, P &lt; 0.001) and personal care (10.5 vs. 0.8%, P &lt; 0.001). Across the entire population, MS patients were more likely to live alone (38.7 vs. 33.8%, P &lt; 0.001) and less likely to have one or more children (84.2 vs. 87.0%, P &lt; 0.001).ConclusionMS presents significant socioeconomic challenges among the elderly population, such as unemployment, reduced income, and increased dependence on social care. These findings underscore the pervasive impact of MS on an individual's life course, extending beyond the clinical symptoms of cognitive and physical impairment.