bluuebunny/crossref_metadata_2025_split huggingface dataset:
Considering Multiecosystem Trade‐Offs Is Critical When Leveraging Systematic Conservation Planning for Restoration
Authors: Van Lanen Nicholas J. , Duchardt Courtney J. , Pejchar Liba , Shyvers Jessica E. , Aldridge Cameron L. 
Published: January 2025

ABSTRACTConservationists are increasingly leveraging systematic conservation planning (SCP) to inform restoration actions that enhance biodiversity. However, restoration frequently drives ecological transformations at local scales, potentially resulting in trade‐offs among wildlife species and communities. The Conservation Interactions Principle (CIP), coined more than 15 years ago, cautions SCP practitioners regarding the importance of jointly and fully evaluating conservation outcomes across the landscape over long timeframes. However, SCP efforts that guide landscape restoration have inadequately addressed the CIP by failing to tabulate the full value of the current ecological state. The increased application of SCP to inform restoration, reliance on increasingly small areas to sustain at‐risk species and ecological communities, ineffective considerations for the changing climate, and increasing numbers of at‐risk species, are collectively intensifying the need to consider unintended consequences when prioritizing sites for restoration. Improper incorporation of the CIP in SCP may result in inefficient use of conservation resources through opportunity costs and/or conservation actions that counteract one another. We suggest SCP practitioners can avoid these consequences through a more detailed accounting of the current ecological benefits to better address the CIP when conducting restoration planning. Specifically, forming interdisciplinary teams with expertise in the current and desired ecosystem states at candidate conservation sites; improving data availability; modeling and computational advancements; and applying structured decision‐making approaches can all improve the integration of the CIP in SCP efforts. Improved trade‐off assessment, spanning multiple ecosystems or states, can facilitate efficient, proactive, and coordinated SCP applications across space and time. In doing so, SCP can effectively guide the siting of restoration actions capable of promoting the full suite of biodiversity in a region.
Efficacy and Safety of Allisartan Isoproxil/Amlodipine in Patients With Essential Hypertension Uncontrolled by Amlodipine: A Phase III, Multicenter, Double‐Blind, Parallel‐Group, Randomized Controlled Trial
Authors: Chi Hongjie , Zhang Xin , Ma Shumei , Pan Gang , Lian Xiaojuan , Chen Yan , Pei Haotian , Liu Zichen , Lin Xiangmin 
Published: January 2025

AbstractThis study aimed to assess the efficacy and safety of a combination therapy of Allisartan Isoproxil 240 mg and Amlodipine 5 mg (ALI/AML) compared to AML 5 mg monotherapy in patients with mild‐to‐moderate essential hypertension. In this phase III, multicenter, double‐blind, parallel‐group, randomized controlled trial, patients aged 18–70 years with mean sitting systolic blood pressure (msSBP) between 140 and <180 mmHg and mean sitting diastolic blood pressure (msDBP) between 90 and <110 mmHg, following a 4‐week treatment with AML 5 mg, were randomized 1:1 to receive either ALI/AML or AML once daily for 12 weeks. This 12‐week double‐blind period was followed by an open‐label extension of ALI/AML treatment through week 52. A total of 300 patients were enrolled, with 149 and 151 patients randomly assigned to ALI/AML and AML groups, respectively. Of these, 257 patients completed the study. Baseline demographics and characteristics were comparable between groups. After 12 weeks, the reduction in msSBP (the primary endpoint) was significantly greater in the ALI/AML group compared to the AML group (–15.7 vs. –10.2 mmHg, p = 0.0019). Similarly, reductions in msDBP (–5.7 vs. –2.4 mmHg, p < 0.001) and 24‐h mean ambulatory SBP and DBP (–10.4 and –7.7 mmHg vs. –5.6 and –3.8 mmHg) were more pronounced in the ALI/AML group. Additionally, a higher proportion of patients achieved both a BP response and target office BP in the ALI/AML group compared to the AML group (51.4% vs. 37.4%, 42.5% vs. 30.6%, both p < 0.05). The ALI/AML combination was generally well tolerated, and the antihypertensive effect was maintained for up to 52 weeks. In patients with essential hypertension inadequately controlled by AML, the ALI/AML combination provided superior reductions in msSBP and was significantly more effective than AML monotherapy. This once‐daily single‐pill combination demonstrated promising efficacy and tolerability.Trial Registration: ClinicalTrials.gov identifier: NCT06465264
Comparison of Influence of Office and 24‐h Central Aortic Blood Pressure on Target Organ Damage in Hypertension
Authors: Hu Yueliang , Yang Hui , Chang Guili , Bai Yaya , Avolio Alberto , Wang Qian , Gao Shenshen , Zuo Junli 
Published: January 2025

ABSTRACTThe aim of this study was to explore whether 24‐h ambulatory central (aortic) blood pressure (BP) has an advantage over office central aortic BP in screening for hypertension‐mediated target organ damage (HMOD). A total of 714 inpatients with primary hypertension and the presence of several cardiovascular risk factors or complications involving clinical HMOD were enrolled. Twenty‐four hour central aortic BP was measured by means of a noninvasive automated oscillometric device (Mobil‐O‐Graph). Office BP was measured with a validated oscillometric Omron device after a 5‐min rest in a sitting position. Central aortic pressure waveforms were derived from the radial pressure waveforms with a validated transfer function of the Sphygmocor software, version 8.0 (Atcor Medical, Sydney, Australia). Carotid–femoral pulse wave velocity (cf‐PWV) measurement was performed by sequential placement of the transducer on the femoral artery and carotid artery and determining transit time between the two pulses in reference to the R wave of the ECG. cf‐PWV was calculated as the measured distance from the suprasternal notch to the femoral artery minus the distance from the suprasternal notch to the carotid artery divided by the pulse transit time. HMOD was defined as the presence of carotid intima–media thickness (IMT) above normal values and/or carotid plaque, left ventricular hypertrophy (LVH), renal abnormalities as assessed by urine albumin/creatinine ratio (ACR) above normal values and/or estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m2 and/or increased cf‐PWV > 10 m/s. In the study cohort of 714 (age 54.52 ± 13.24 years, 74.6% male) patients with primary hypertension, LV mass index (LVMI) was significantly higher in males (p < 0.002) and eGFR was significantly lower in males (p < 0.001). However, there was no statistical significance between males and females in IMT, ACR, and cfPWV. When accounting for confounding factors (age, sex, BMI, triglycerides, total cholesterol, LDL, glucose, smoking, and heart rate), central systolic (cSBP), diastolic (DBP), and pulse (cPP) pressure obtained with 24‐h monitoring was more strongly correlated with LVMI than office measurements. Twenty‐four hour cSBP and cPP were more strongly correlated with IMT than those of office monitoring. The 24‐h augmentation index (AIx) was more strongly correlated with eGFR than office AIX. Twnety‐four hour cSBP and cPP were more strongly correlated with lgACR. Office AIx and cPP were more strongly correlated with c‐fPWV than 24‐h measurements while cSBP, DBP, and cPP obtained by both methods were equally correlated with c‐fPWV. Ambulatory central (aortic) pressure may be more strongly related to HMOD than office CAP which may have an advantage in screening for c‐fPWV.Trial Registration: Registration number: ChiCTR2000040308
Association of Red Blood Cell Distribution Width With Carotid–Femoral Pulse Wave Velocity in a Southern Chinese Population
Authors: Yu Xing , Huang Yali , Su Yunyun , Xie Liangdi 
Published: January 2025

ABSTRACTRed blood cell distribution width (RDW) has recently been recognized as a novel biomarker associated with various cardiovascular conditions. This study aims to investigate the relationship between RDW and carotid–femoral pulse wave velocity (cfPWV) in a southern Chinese population. A total of 4916 patients were initially enrolled from the First Affiliated Hospital of Fujian Medical University between January 2016 and December 2022. Based on the criteria of inclusion and exclusion, 2830 patients were included in this study. Body weight, height, and blood pressure were measured, and clinical biochemical tests were recorded. cfPWV was assessed using a non‐invasive automatic device. Spearman's correlation analysis, generalized linear regression analysis, multivariable logistic regression, and stratified analysis were conducted to assess the correlation between RDW and cfPWV. Participants were stratified into four subgroups based on RDW quartiles: Q1 (RDW ≤ 12.80%), Q2 (12.80% < RDW ≤ 13.40%), Q3 (13.40% < RDW ≤ 14.10%), and Q4 (RDW > 14.10%). A significant increase in age, systolic blood pressure, cfPWV, and HbA1c levels was observed with higher RDW quartiles. Both Spearman's correlation analysis and generalized linear regression analysis revealed a significant association between RDW and cfPWV. Specifically, compared to the lowest quartile, the risk of cfPWV≥10 m/s increased by 56% in the highest quartile (odds ratio = 1.564, p < 0.001). This correlation persisted particularly among the elderly, hypertensive patients who were not taking medication, and those who were taking medication but had poor control. The plasma RDW level was significantly associated with cfPWV in a southern Chinese population, particularly among older adults and individuals with hypertension, suggesting RDW as a potential marker for arterial stiffness.
A Modified Ligature‐Induced Peri‐Implantitis Murine Model and RNA Sequencing Analysis Compared With Human Subjects
Authors: Tong Zi‐an , Chen Long , Shen Ling , Lu Yi‐fan , Zhang Jian‐wei , Qi Ya‐dong , Qian Yin‐jie , Bao Si‐qi , Chen Wei , Si Mi‐si 
Published: January 2025

ABSTRACTAimTo propose a modified method for establishing a peri‐implantitis murine model, assess the gene expression profile and immune cell infiltration of the gingiva and alveolar bone, and evaluate the transcriptomic similarity between patients with peri‐implantitis and the corresponding murine model.Materials and MethodsA ligature‐induced peri‐implantitis murine model was established using an immediate implant placement approach. RNA sequencing was performed to determine the transcriptomic profiles of peri‐implant tissues from mice, patients with peri‐implantitis and healthy individuals. Histopathological and bioinformatics analyses were performed to measure immune cell infiltration, bone remodelling, and inflammatory reactions.ResultsMouse gingival tissue showed strong immune and inflammatory responses, especially macrophage functions; these responses were weaker in the alveolar bone. Humans and mice showed similar gene expression patterns in the gingiva, with greater infiltration of macrophages and neutrophils.ConclusionsDuring peri‐implantitis progression, mouse gingival tissue exhibited increased immune‐related functions and inflammation compared with the alveolar bone. Patients with peri‐implantitis and the murine model displayed transcriptomic similarities within the gingiva. We propose that the modified ligature‐induced peri‐implantitis murine model is suitable for investigating peri‐implantitis pathogenesis, with macrophages and neutrophils potentially being critical in its development.
Influence of Opening Size and Position on the Performance of Forced‐Air Precooling of Apples
Authors: Chen Xiaozhuan , Wang Yunpeng , Sheng Wei , Zheng Haikun , Bayizi Maierzukejiang , Pan Shishun , Liu Sikai , Li Dong 
Published: January 2025

ABSTRACTIn this article, to investigate the comprehensive influence of the opening size and location of the packing box on precooling performance, a simulation model of precooling with 20 opening parameters is established based on computational fluid dynamics. There are six openings on one side of the box, 12 in total, with 5 opening positions (Cases 1–5) and 4 opening sizes, each with an opening size and corresponding total opening area of 15 mm (2120 mm2), 30 mm (8482 mm2), 45 mm (19,085 mm2), and 60 mm (33,929 mm2). The results show that when the diameter of the opening is 15–60 mm, increasing the opening increases the precooling time, and Case 4, which moves the position of the openings on both sides to the left and right, reduces the precooling time. Increasing the opening does not necessarily improve precooling uniformity at different opening positions. Case 5, with the position of the two side openings moved toward the center, had the worst precooling uniformity for each opening size. The larger the opening, the lower the precooling energy consumption for a given opening position. This is because the reduction in power at increased opening is much greater than the increase in precooling time. When the opening size is certain, the reasonable opening position can reduce the precooling energy consumption. Case 4, 30 mm is more balanced overall. Therefore, the opening parameter has a large impact on the precooling performance, and it is necessary to select the opening parameter reasonably for different requirements.
Unveiling the Molecular Mechanisms of Rosacea: Insights From Transcriptomics and In Vitro Experiments
Authors: Chen Luzhu , Wang Juan 
Published: January 2025

ABSTRACTBackgroundRosacea is a prevalent inflammatory skin condition, but its molecular mechanisms and treatment responses remain poorly understood.AimsThis study aims to investigate the molecular mechanisms underlying rosacea and explore drug response through transcriptomic analysis and in vitro experiments.Patients/MethodsWe performed high‐throughput RNA sequencing to analyze gene expression patterns in rosacea patients. In vitro experiments, including RT‐qPCR, Western blot, ELISA, scratch, and Transwell assays, were used to evaluate gene and protein expression and cell behavior in HaCaT cells under simulated rosacea conditions.ResultsTranscriptomic analysis revealed significantly elevated expression of inflammatory‐related genes in rosacea patients. In vitro, HaCaT cells exhibited enhanced proliferation and migration abilities, accompanied by increased expression of pro‐inflammatory genes and proteins. Specifically, Toll‐like receptor 2 (TLR2) and S100A9 proteins were upregulated, potentially promoting these processes.ConclusionsOur study elucidates the molecular mechanisms of rosacea, highlighting the role of inflammatory pathways and altered cell behavior in the disease. TLR2 and S100A9 may contribute to disease progression, offering potential targets for future therapeutic strategies.
DAA‐PASS: A Prospective Evaluation of HCC Recurrence After Direct Acting Antiviral Therapy
Authors: Singal Amit G. , Reddy K. Rajender , Colombo Massimo , Morris Heather L. , Mospan Andrea R. , Cabrera Roniel , Kelley Robin K. , Kilpatrick Ryan D. , Trevisani Franco , Farinati Fabio , Giannini Edoardo G. , Mehta Neil , Fried Michael W. , Sangro Bruno ,   the DAA‐PASS and ITA.LI.CA Investigators
Published: January 2025

ABSTRACTDirect‐acting antiviral (DAA) therapy is associated with a significant reduction in hepatocellular carcinoma (HCC) incidence among patients with cirrhosis, but data are conflicting about the risk of recurrence following DAA therapy. DAA‐PASS was a prospective, pragmatic, observational study designed to estimate the risk of HCC recurrence associated with DAA therapy exposure during routine clinical care. Eligible patients were DAA treatment naive with Barcelona Clinic Liver Cancer (BCLC) stage A. Patients were followed at regular intervals for up to 24 months. To provide additional data, outcomes were compared to the Italian Liver Cancer Group (ITA.LI.CA) cohort. Of 42 patients enrolled, 24 were treated with DAA therapy. Ten HCC recurrence events were observed during the study, with 5 each in DAA‐treated and DAA‐untreated patients (cumulative incidences of 23 and 37 per 100 PY, respectively). The overall crude hazard ratio (HR) for HCC recurrence associated with DAA therapy was 0.6 (95% CI, 0.2–2.2). In the ITA.LI.CA cohort, HCC recurrence was observed in 193 patients during 24 months of follow‐up, resulting in a cumulative incidence rate of 28 per 100 PY. Although limited by small sample size, this prospective study suggests DAA therapy is not associated with increased HCC recurrence risk among patients with a history of complete response to prior HCC therapy.
Fish protein hydrolysates from rainbow trout processing in replacement of feed protein sources: Effects on growth performances, liver status and body composition of gilthead sea bream, Sparus aurata L., juveniles
Authors: Cappuccinelli Roberto , Fiordelmondo Elisa , Magi Gian Enrico , Mariotti Francesca , Sanna Manuela , Galosi Livio , Roggio Tonina , Roncarati Alessandra 
Published: January 2025

AbstractThe use of processing by‐products may reduce pressure on fish stocks as well as diminish wastes and negative environmental impact. Different studies investigated fish by‐products used as alternative nutritional source to conventional feedstuffs. Fish protein hydrolysates (FPH), as a protein source derived from discards of rainbow trout processing, were included in feeds and effects were evaluated on productive performances, liver status, and body composition in gilthead sea bream, Sparus aurata L., juveniles. Three groups of 170 juveniles each (initial weight 37.8 ± 0.5 g), in triplicate indoor tanks of 2 m3 volume each, were fed including FPH in L1 (7.5 g/kg) and L2 (15 g/kg) feeds in replacement of fishmeal. LC diet was used as control having fish meal and soybean meal as main protein sources. At the end of the trial (85 days), satisfactory productive performances were obtained in all the groups with similar performances. The final mean weight ranged from 76.6 to 78.0 g. The two FPH diets exhibited high palatability equal to LC. Liver histology did not differ although fat accumulation was detected in all fish. Body composition and fatty acids were similar. FPH as substitute of protein source is suitable in the feeding of gilthead sea bream juveniles.
Imported Systemic Endemic Mycoses in Spain 1997–2021: An Analysis of a National Hospital Database
Authors: Llenas‐García Jara , González Beiro Roberto , Ramos‐Rincón José‐Manuel , Wikman‐Jorgensen Philip 
Published: January 2025

ABSTRACTBackgroundSystemic endemic mycoses are systemic fungal infections typically found in tropical and subtropical regions. Their global incidence is rising, including in nonendemic countries, mainly due to migration and international travel. They are a major cause of morbidity and mortality worldwide, especially in immunocompromised patients. This study aimed to analyse incidence trends of endemic mycoses and their presentation in hospitalised patients in Spain from 1997 to 2021.MethodsThis retrospective, observational study drew data from the Spanish National Hospital Discharge Database. We used the diagnostic codes of the 9th and 10th International Classification of Diseases for histoplasmosis, coccidioidomycosis, paracoccidioidomycosis and talaromycosis, retrieving systemic endemic mycoses cases from the national public registry.ResultsOver the study period, 646 cases of histoplasmosis, 138 of coccidioidomycosis, 47 of paracoccidioidomycosis and 24 talaromycosis were reported, with a rising number of cases annually, driven mainly by an increase in histoplasmosis. A segmented linear regression predictive model with a 10‐year forecast showed a steady increase, reaching 128 hospitalisations (95% confidence interval [CI] 87–168) in Spain in 2031. Overall, in‐hospital mortality was 10.9%, higher in histoplasmosis (11.3%) and coccidioidomycosis (10.9%) and independently associated with immunosuppression for both histoplasmosis (adjusted odds ratio [aOR] 3.28, 95% CI 1.72–6.24; p < 0.001) and coccidioidomycosis (aOR 4.05, 95% CI 1.22–13.44; p = 0.022).ConclusionsHospitalisations for systemic endemic mycoses, especially histoplasmosis, are on the rise in Spain. Mortality is significant and primarily associated with immunosuppression. This trend is expected to continue in the coming years, underscoring the importance of maintaining hospital‐based surveillance of endemic mycoses in nonendemic regions.
Outcomes in Patients With Henoch–Schönlein Purpura After Kidney Transplantation: A Propensity Score Matched Study
Authors: Ebadinejad Amir , Silver Elizabeth , O’Sullivan David M. , Dar Wasim , Morgan Glyn , Emmanuel Bishoy , Cobar Juan P. , Ye Xiaoyi , Singh Joseph U. , Kent Rebecca , Tremaglio Joseph , Serrano Oscar K. 
Published: January 2025

ABSTRACTAimHenoch–Schönlein purpura (HSP) nephritis leads to end‐stage renal disease (ESRD) in upto 3% of cases, necessitating kidney transplantation (KT). This study compared graft and patient survival outcomes between HSP and non‐HSP KT recipients and identified factors associated with HSP recurrence.MethodsData from the Scientific Registry of Transplant Recipients (SRTR) were analysed for adult and paediatric KT patients listed between January 2005 and April 2021. HSP recipients were extracted from the database and non‐HSP recipients were selected and propensity‐matched 3:1 based on demographic factors.ResultsA total of 371 KT recipients with HSP were matched to 1113 non‐HSP recipients. When stratified by age, adult and paediatric HSP patients showed similar death‐censored graft survival (DCGS) at 5 years compared to their non‐HSP counterparts. Furthermore, paediatric patients with HSP had comparable DCGS to adult HSP patients at 5 years (86.5% vs. 88.3%, p = 0.221). Amongst HSP recipients, 27.2% experienced recurrence, with higher rates in adults (29.7%) compared to children (13.0%). Recurrent HSP was associated with increased graft failure and mortality. Regression analysis showed that older age (OR [95% CI]: 1.018 (1.001–1.035), p = 0.037) was associated with a higher risk of recurrence, while a higher BMI (0.95 [0.91–0.99], p = 0.020) was linked to a lower risk.ConclusionIn a contemporary cohort of HSP KT patients, graft survival was comparable between HSP and matched non‐HSP patients in both adult and paediatric groups. However, graft loss was more frequent in HSP patients who experienced disease recurrence.