bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preliminary Experience with Continuous Submucosal Anastomosis in Small-Diameter Hepaticojejunostomy during Single-Port Laparoscopic Choledochal Cyst Surgery in Children
Authors: Tang Yingming , Zhang Jie , Luo Miao , Li Fei , Huang Huang , Zhou Zhou , Fan Xia , Qin Zhijie , He Guoqing , Zhuang Yize 
Published: July 2023

Abstract
Purpose Hepaticojejunostomy anastomosis (HJA) is the most challenging aspect in single-port laparoscopic choledochal cystectomy and Roux-en-Y hepaticojejunostomy (SPCH) in children, especially in small-diameter anastomoses (diameters less than 5 mm), which are more susceptible to anastomotic stricture. We developed the continuous submucosal technique for HJA (CS-HJA) to lessen postoperative complications. The purpose of this study is to introduce our preliminary experiences with CS-HJA.
Methods We retrospectively analyzed all available clinical data of children who underwent SPCH surgery between March 2020 and October 2022. We operated with CS-HJA on 10 children who were diagnosed with small-diameter hepaticojejunostomy (diameter less than 5 mm). Data collection mainly included demographic information, imaging data, perioperative details, and postoperative outcomes. Ten patients were included in this study. The average patient age was 55.2 months; the age range was 3 to 120 months, and the average weight was 11.6 kg; male–female ratio was 1:9. The choledocho had fusiform dilatation in five cases and cystic dilatation in five cases. There was no dilatation of the left and right hepatic ducts or intrahepatic bile ducts in all patients. All patients had no dilatation of the left and right hepatic ducts or intrahepatic bile ducts. All patients underwent a single-port laparoscopic bile-intestinal anastomosis using a submucosal jejunal anastomosis technique. Analysis of the duration of the bile-intestinal anastomosis, the length of the child's stay in the hospital after surgery, the intraoperative complications, and the postoperative complications was performed.
Results All the 10 patients underwent successful SPCH by CS-HJA technique. The average length of time for hepaticojejunostomy ranged from 22 to 40 minutes, and the postoperative hospital stay was 5.2 to 9.2 days. There were no instances of bile leakage following the operation. At 17 to 30 months of follow-up, there was no abdominal pain or jaundice, and the reexamination of transaminases, bilirubin, and amylase were normal. Ultrasonography showed no bile duct stricture or dilated bile ducts, and the incision is elegant, and the families of the patients were satisfied.
Conclusion In SPCH surgery in children, the CS-HJA technique is safe and feasible for small-diameter hepaticojejunostomy.
Chemoprevention in Inherited Colorectal Cancer Syndromes
Authors: Gilad Ophir , Muller Charles , Kupfer Sonia S. 
Published: July 2023

AbstractCancer prevention in hereditary gastrointestinal predisposition syndromes relies primarily on intensive screening (e.g., colonoscopy) or prophylactic surgery (e.g., colectomy). The use of chemopreventive agents as an adjunct to these measures has long been studied both in the general population and in hereditary cancer patients, in whom the risk of malignancy, and therefore the potential risk reduction, is considerably greater. However, to date only few compounds have been found to be effective, safe, and tolerable for widespread use. Furthermore, many of the studies involving these rare syndromes suffer from small sample sizes, heterogeneous patient cohorts, short follow-up duration, and lack of standardized endpoints, creating challenges to draw generalizable conclusion regarding efficacy. The following review summarizes the current data on various chemopreventive compounds used in Lynch syndrome and familial adenomatous polyposis in addition to several agents that are currently being investigated.
Shared Decision-Making, Sphincter Preservation, and Rectal Cancer Treatment: Identifying and Executing What Matters Most to Patients
Authors: Ivatury Srinivas Joga , Suwanabol Pasithorn A. , Roo Ana C. De 
Published: July 2023

AbstractRectal cancer treatment often encompasses multiple steps and options, with benefits and risks that vary based on the individual. Additionally, patients facing rectal cancer often have preferences regarding overall quality of life, which includes bowel function, sphincter preservation, and ostomies. This article reviews these data in the context of shared decision-making approaches in an effort to better inform patients deliberating treatment options for rectal cancer.
Fabric defect detection based on anchor-free network
Authors: Wang Xianbao , Fang Weijie , Xiang Sheng 
Published: July 2023

Abstract
Fabrics play a pivotal role in human life and production, and surface defects can directly affect the quality and value of fabrics. Many methods for fabric defect detection have been proposed, but tiny defects are still difficult to be detected effectively, and the accuracy of defect localization and classification is low. To address these issues, a modified YOLOX network called YOLOX-CATD is proposed, which was supplemented with a coordinate attention module (CAM) and tiny defect detection layer (TDDL) for fast and efficient detection of fabric defects, especially tiny defects. Firstly, the anchor-free network is used as the detection framework to avoid the influence of hyperparameters of the setting anchor. Secondly, a CAM is proposed to enhance the representation of the object of interest in the input feature map and suppress the background regions. Finally, a TDDL is added to introduce high-resolution features to improve the localization accuracy of tiny defects. The experimental results on the Aliyun Tianchi Fabric dataset and NEU-DET demonstrate the superiority and generalization of the modified model. The mean average precision (mAP) of YOLOX-CATD on the fabric defect dataset is improved by 5.67% compared to the original YOLOX, and the detection speed can reach 35–36 frames per second (FPS). This proves that YOLOX-CATD can obtain excellent fabric defect detection performance and meet the urgent need for real-time detection in industrial applications.
Recent advances in MXene-based nanocomposites for supercapacitors
Authors: Yi Sha , Wang Lei , Zhang Xiong , Li Chen , Xu Yanan , Wang Kai , Sun Xianzhong , Ma Yanwei 
Published: July 2023

Abstract
MXene materials have become a competitive candidate for electrochemical energy storage due to their unique two-dimensional layered structure, high density, metal-like conductivity, fast ion intercalation, tunable surface terminal groups, and good mechanical flexibilities, showing unique application advantages in the field of supercapacitors. With widely research of MXene in energy storage applications, plenty of studies in synthesis strategies of MXene, including etching, intercalation and exfoliation processes, and its charge storage mechanism in supercapacitors have been conducted. However, the restacking of two-dimensional MXene nanosheets severely affects their electrochemical performance. To prevent the stacking of MXene, MXene-based nanocomposite electrode materials have been developed with remarkable electrochemical performance by incorporating conventional active capacitive materials, including metal oxides/sulfides and conductive polymers, with MXene. This review summarizes the etching strategies of MXenes and selection of intercalants, also discusses the charge storage mechanism of MXenes in aqueous and nonaqueous electrolytes. It mainly expounds the preparation strategies and applications of MXene-based nanocomposites in supercapacitors, including MXene/metal oxide, MXene/metal sulfide, MXene/conducting polymer, and MXene/carbon-based composites. Additionally, the advantages of combining MXene with other active materials in supercapacitor applications, which support its promising prospects, are discussed. Finally, the critical challenges faced by MXene-based nanocomposites in long-term research are mentioned.
Cascaded solenoid acceleration of vortex laser-driven collimated proton beam
Authors: Sun X Y , Wang W P , Dong H , He J Z , Shi Z Y , Leng Y X , Li R X , Xu Z Z 
Published: July 2023

Abstract
Efficient cascaded proton acceleration driven by an intense Laguerre–Gaussian (LG) laser is realized in combined three-dimensional particle-in-cell simulations and CST STUDIO SUITE (CST) simulations. CST simulations show that there is no divergent force component in the transverse direction in the coil center. Therefore, the collimated proton beam driven by the LG laser in the first stage benefits from the uniform beam acceleration in the second stage. By contrast, the proton beam with larger divergence disperses to the outside of the coil because of the divergent force near the coil wire in the Gaussian laser case. Finally, a quasi-monoenergetic proton beam with a higher flux is generated by the LG laser, which is much better than the Gaussian laser case. The obtained proton beam can potentially be used in some special applications, such as proton radiography, fast ignition of fusion targets, biomedical applications, and production of warm dense matter.
Direct reconstruction of isolated XUV or soft x-ray attosecond pulses from high-harmonic generation streaking spectra
Authors: Wang Kan , Fu Yong , Li Baochang , Tang Xiangyu , Wang Bincheng , Guan Zhong , Lin C D , Jin Cheng 
Published: July 2023

Abstract
Characterization of an isolated attosecond pulse (IAP) in the extreme ultraviolet (XUV) or soft x-ray (SXR) region is essential for its applications. Here we propose to retrieve an IAP in the time domain directly through the modulation of high-harmonic generation (HHG) spectra in the presence of a time-delayed intense few-cycle infrared or mid-infrared laser. The retrieval algorithm is derived based on the strong-field approximation and an extended quantitative rescattering model. We show that both isolated XUV pulses with a narrow spectral bandwidth and isolated SXR pulses with a broad bandwidth can be well characterized through the HHG streaking spectra. Such an all-optical method for characterizing the IAP differs from the commonly used approach based on the streaked photoelectron spectra that would require electron spectrometers. We check the robustness of the retrieval method by changing the dressing laser or by adjusting the steps of time delay. We also show that the XUV pulse can be accurately retrieved by treating the HHG streaking spectra calculated from solving the time-dependent Schrödinger equation for single atoms as the ‘experimental’ data.
Enhancing adversarial robustness of quantum neural networks by adding noise layers
Authors: Huang Chenyi , Zhang Shibin 
Published: July 2023

Abstract
The rapid advancements in machine learning and quantum computing have given rise to a new research frontier: quantum machine learning. Quantum models designed for tackling classification problems possess the potential to deliver speed enhancements and superior predictive accuracy compared to their classical counterparts. However, recent research has revealed that quantum neural networks (QNNs), akin to their classical deep neural network-based classifier counterparts, are vulnerable to adversarial attacks. In these attacks, meticulously designed perturbations added to clean input data can result in QNNs producing incorrect predictions with high confidence. To mitigate this issue, we suggest enhancing the adversarial robustness of quantum machine learning systems by incorporating noise layers into QNNs. This is accomplished by solving a Min-Max optimization problem to control the magnitude of the noise, thereby increasing the QNN’s resilience against adversarial attacks. Extensive numerical experiments illustrate that our proposed method outperforms state-of-the-art defense techniques in terms of both clean and robust accuracy.
An imbalance of excitation and inhibition in the multisensory cortex impairs the temporal acuity of audiovisual processing and perception
Authors: Schormans Ashley L , Allman Brian L 
Published: July 2023

Abstract
The neural integration of closely timed auditory and visual stimuli can offer several behavioral advantages; however, an overly broad window of temporal integration—a phenomenon observed in various neurodevelopmental disorders—could have far-reaching perceptual consequences. Non-invasive studies in humans have suggested that the level of GABAergic inhibition in the multisensory cortex influences the temporal window over which auditory and visual stimuli are bound into a unified percept. Although this suggestion aligns with the theory that an imbalance of cortical excitation and inhibition alters multisensory processing, no prior studies have performed experimental manipulations to determine the causal effects of a reduction of GABAergic inhibition on audiovisual temporal perception. To that end, we used a combination of in vivo electrophysiology, neuropharmacology, and translational behavioral testing in rats to provide the first mechanistic evidence that a reduction of GABAergic inhibition in the audiovisual cortex is sufficient to disrupt unisensory and multisensory processing across the cortical layers, and ultimately impair the temporal acuity of audiovisual perception and its rapid adaptation to recent sensory experience. Looking forward, our findings provide support for using rat models to further investigate the neural mechanisms underlying the audiovisual perceptual alterations observed in neurodevelopmental disorders, such as autism, schizophrenia, and dyslexia.
A Single Case Observation: Is the Ebola Virus Soluble Glycoprotein an Indicator of Viral Recrudescence?
Authors: Furuyama Wakako , Davey Richard T , Chertow Daniel S , Marzi Andrea 
Published: July 2023

Abstract
This case study investigated the long-term expression dynamics of Ebola virus (EBOV) soluble glycoprotein (sGP) in the serum of a patient who was infected with EBOV in West Africa and recovered from acute Ebola virus disease (EVD) at the National Institutes of Health Clinical Center in Bethesda, Maryland. Samples from this patient were collected during acute EVD and during convalescence up to day 361 following illness onset. Although blood samples were negative by reverse transcription–quantitative polymerase chain reaction after recovery from acute EVD, we detected small amounts of EBOV sGP in the serum of the patient long after recovery, potentially indicating viral recrudescence. As this was only observed in a single patient, additional longitudinal patient samples are needed to confirm our hypothesis that EBOV sGP may be an indicator of viral recrudescence long after recovery from acute EVD.
Glucosinolate Catabolism Maintains Glucosinolate Profiles and Transport in Sulfur-Starved Arabidopsis
Authors: Zhang Liu , Kawaguchi Ryota , Enomoto Takuo , Nishida Sho , Burow Meike , Maruyama-Nakashita Akiko 
Published: July 2023

Abstract
Glucosinolates (GSLs) are sulfur (S)-rich specialized metabolites present in Brassicales order plants. Our previous study found that GSL can function as a S source in Arabidopsis seedlings via its catabolism catalyzed by two β-glucosidases (BGLUs), BGLU28 and BGLU30. However, as GSL profiles in plants vary among growth stages and organs, the potential contribution of BGLU28/30-dependent GSL catabolism at the reproductive growth stage needs verification. Thus, in this study, we assessed growth, metabolic and transcriptional phenotypes of mature bglu28/30 double mutants grown under different S conditions. Our results showed that compared to wild-type plants grown under −S, mature bglu28/30 mutants displayed impaired growth and accumulated increased levels of GSL in their reproductive organs and rosette leaves of before-bolting plants. In contrast, the levels of primary S-containing metabolites, glutathione and cysteine decreased in their mature seeds. Furthermore, the transport of GSL from rosette leaves to the reproductive organs was stimulated in the bglu28/30 mutants under −S. Transcriptome analysis revealed that genes related to other biological processes, such as ethylene response, defense response and plant response to heat, responded differentially to −S in the bglu28/30 mutants. Altogether, these findings broadened our understanding of the roles of BGLU28/30-dependent GSL catabolism in plant adaptation to nutrient stress.
Jasmonates regulate apical hook development by repressing brassinosteroid biosynthesis and signaling
Authors: Zhang Jingjie , Chen Weiyue , Li Xiaopeng , Shi Hongyong , Lv Minghui , He Liming , Bai Wenhua , Cheng Shujing , Chu Jinfang , He Kai , Gou Xiaoping , Li Jia 
Published: July 2023

Abstract
An apical hook is a special structure formed during skotomorphogenesis in dicotyledonous plant species. It is critical for protecting the shoot apical meristem from mechanical damage during seed germination and hypocotyl elongation in soil. Brassinosteroid (BR) and jasmonate (JA) phytohormones antagonistically regulate apical hook formation. However, the interrelationship between BRs and JAs in this process has not been well elucidated. Here, we reveal that JAs repress BRs to regulate apical hook development in Arabidopsis (Arabidopsis thaliana). Exogenous application of methyl jasmonate (MeJA) repressed the expression of the rate-limiting BR biosynthetic gene DWARF4 (DWF4) in a process relying on 3 key JA-dependent transcription factors, MYC2, MYC3, and MYC4. We demonstrated that MYC2 interacts with the critical BR-activated transcription factor BRASSINAZOLE RESISTANT 1 (BZR1), disrupting the association of BZR1 with its partner transcription factors, such as those of the PHYTOCHROME INTERACTING FACTOR (PIF) family and downregulating the expression of their target genes, such as WAVY ROOT GROWTH 2 (WAG2), encoding a protein kinase essential for apical hook development. Our results indicate that JAs not only repress the expression of BR biosynthetic gene DWF4 but, more importantly, attenuate BR signaling by inhibiting the transcriptional activation of BZR1 by MYC2 during apical hook development.
Susceptibility of nucleotide-binding oligomerization domain 2 mutations to Whipple’s disease
Authors: Williamson Katrina A , Yun Mark , Koster Matthew J , Arment Courtney , Patnaik Asha , Chang Tara W , Bledsoe Adam C , Sae-Tia Sutthichai , Shah Aditya S , Samuels Jonathan , Davis John M , Yao Qingping 
Published: July 2023

Abstract

Objectives
Whipple’s disease (WD) results from infection of the bacteria Tropheryma whipplei (TW). This disease is characterized by macrophage infiltration of intestinal mucosa and primarily affects Caucasian males. Genetic studies of host susceptibility are scarce. Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is an innate immune sensor, resides mainly in monocytes/macrophages and contributes to defence against infection and inflammatory regulation. NOD2 mutations are associated with autoinflammatory diseases. We report the association of NOD2 mutations with TW and WD for the first time.

Methods
A multicentre, retrospective study of three patients with WD was conducted. Patients received extensive multidisciplinary evaluations and were cared for by the authors. NOD2 and its association with infection and inflammation were schematically represented.

Results
All patients were Caucasian men and presented with years of autoinflammatory phenotypes, including recurrent fever, rash, inflammatory arthritis, gastrointestinal symptoms and elevated inflammatory markers. All patients underwent molecular testing using a gene panel for periodic fever syndromes and were identified to carry NOD2 mutations associated with NOD2-associated autoinflammatory disease. Despite initially negative gastrointestinal evaluations, repeat endoscopy with duodenal tissue biopsy ultimately confirmed WD. After initial ceftriaxone and maintenance with doxycycline and/or HCQ, symptoms were largely controlled, though mild relapses occurred in follow-up.

Conclusion
Both NOD2 and TW/WD are intensively involved in monocytes/macrophages. WD is regarded as a macrophage disease. NOD2 leucin-rich repeat–associated mutations in monocytes/macrophages cause functional impairment of these cells and consequently may make the host susceptible for TW infection and WD, especially in the setting of immunosuppression.
Epidemiology and Comparative Analysis of Outcomes of Intramedullary Spinal Cord Tumor Between Pediatric and Adult Patients
Authors: Umebayashi Daisuke , Naito Kentaro , Kurokawa Ryu , Endo Toshiki , Mizuno Masaki , Hoshimaru Minoru , Kim Phyo , Hida Kazutoshi , Takami Toshihiro ,   Neurospinal Society of Japan Intramedullary Tumor Study Collaborators
Published: July 2023

Study Design.
This was as clinical retrospective study.

Objectives.
We sought to evaluate the characteristics of Pediatric intramedullary spinal cord tumors (PISCTs) and to identify differences between pediatric and adult intramedullary spinal cord tumors.

Summary of Background Data.
PISCTs represent a rare clinical entity with limited evidence-base in the literature.

Methods.
This study is a subanalysis of the retrospective multicenter observational study authorized by the Neurospinal Society of Japan, including consecutive patients with spinal intramedullary tumors treated surgically at 58 institutions between 2009 and 2020. Data on 1080 intramedullary spinal cord tumors were obtained, consisting of 91 pediatric and 939 adult patients. Survival was compared using Cox hazard regression while clinical differences were evaluated using multivariable logistic regression that controlled for confounders.

Results.
Pediatric patients had a shorter overall, and progression-free, survival than adults. Pediatric patients with ISCTs were likely to have scoliosis [odds ratio (OR) = 6.49, 95% CI: 2.26–18.7], short preoperative symptom duration (OR = 0.99, 95% CI: 0.98–0.99), lower incidence of paresthesia (OR = 0.41, 95% CI: 0.22–0.77), higher incidence of paresis (OR = 2.10, 95% CI: 1.01–4.35), histopathology of astrocytoma (OR = 2.97, 95% CI: 1.19–7.43), and postoperative functional deterioration upon discharge (OR = 2.83, 95% CI: 1.43–5.58). Age was not a statistically significant prognostic factor of overall survival among the pediatric cohort.

Conclusion.
We found that the clinical characteristics of ISCTs differed between pediatric and adult patients. In terms of histopathological types, astrocytoma was most common in pediatric patients. ISCT occurring at an early age may not be an indicator for poor prognosis.