bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential of Indonesian Medicinal Plant Biodiversity as CHK1 Inhibitor Agent for Cancer Treatment by Bioinformatics and Computational Chemistry
Authors: Austin Alfredo , Colyson Jacklyn Hermione , Rohmatulloh Fauzian Giansyah , Destriani Wanda , Rosyati Margaretha Maria 
Published: July 2023

Indonesia is rich in flora diversity thanks to its biodiversity that has the potential as compounds that can be validated as candidate CHK1 inhibitor agents. The research was conducted in silico by performing molecular tethering using Autodock tools. The reference ligand was found from the 4FT3 receptor with the H1K code on the PDB. The result of docking in reference ligand obtained a Gibbs free energy value of -6.48 kcal/mol. The next process was carried out molecular tethering to 24 selected test compounds. The processes carried out are molecular docking, molecular visualisation, "Lipinski's Rule of Five" testing and Pre-ADMET testing. Based on Gibbs free energy, 18 molecules met the criteria and the best 3 were selected for analysis, namely stigmasterol, laurifolin, and quercetin with Gibbs free energy values of -10.40 kcal/mol, -8.70 kcal/mol, and -8.04 kcal/mol respectively. Based on the Pre-ADMET test, quercetin belongs to GSH toxicity class 4 which means the compound has a mild toxicity effect compared to other compounds. The molecular dynamics results showed that quercetin is the most stable compound and binds the longest compared to the others. The results can be continued for further research through laboratory testing stages in vitro and in vivo.
Physical Stability of Guava Leaves Extract at Different Storage Temperature
Authors: Ambarwati Nadya , Sinulingga Amanda Safithri , Purbosari Ira 
Published: July 2023

Guava (Psidium guajava L.) has been widely used by Indonesian people as traditional medicine. Guava leaves have been studied and show various pharmacological activities including antidiarrheal, antioxidant, anti-inflammatory, analgesic, antimutagenic, anti-cough, antibacterial, antifungal, antiplaque, suppresses cardiac muscle inotropism, antidiabetic, antihypertensive, hepatoprotective and anticoagulant. In Indonesia, guava leaves have been formulated into several dosage forms. The guava leaves extract, as raw material of traditional medicine, should perform stability during storage period. This study aims to test the physical stability of guava leaves extract, which includes organoleptic, pH, and viscosity at different storage temperature and time susceptibility. Extraction was carried out by maceration method using ethanol 96% as solvent. Extraction is done until a thick extract is obtained. The extract was stored at 8oC (refrigerator temperature), 27oC (room temperature), and 70oC (oven temperature). Physical stability test was performed before storage period and at 1st, 2nd, 3rd week of storage period. Stability test results showed that ethanolic extract of guava leaves was stable at different storage temperatures. The results showed no differences on organoleptic, pH and viscosity test before storage period and at 1st, 2nd, 3rd week of storage period. Key words: Physical stability, Guava leaves, Ethanolic extract
Formulation and Physical Stability Test Peel Off Mask from Kokang Leaf Extract ( Lepisanthes amoena (Haask) Leenh) as an Antioxidant
Authors: Pratiwi Jati 
Published: July 2023

Free radicals are substances that can damage skin cell membranes and damage skin cells resulting in melanogenesis which is the main defense of the skin. So that antioxidants are needed as an antidote to free radicals that can inhibit or neutralize the bad effects of free radicals and are formulated in the form of peel-off masks to remove dirt and dead skin cells. Kokang leaves (Lepisanthes amoena (Haask) Leenh) is a plant rich in antioxidants originating from East Kalimantan which contains alkaloids, flavonoids, saponins and tannins. This study aims to determine the characteristics and physical stability as well as determine the antioxidant activity of peel off mask preparations of kokang leaf extract (Lepisanthes amoena (Haask) Leenh), experimentally using the DPPH method with a UV-Vis spectrophotometer. The results and conclusions obtained were that kokang leaf extract (Lepisanthes amoena (Haask) Leenh) peel off mask preparations 1 (0%), 2 (1%), 3 (2.5) and 4 (5%) had physical characteristics and stability good tests (meet standard requirements) including organoleptic tests, pH, homogeneity, spreadability, adhesion, drying time and viscosity. Testing the antioxidant activity using a concentration of 5%. Kokang leaf extract contains strong antioxidant activity with a value of 59,707 ppm, while kokang leaf extract peel off mask contains medium category antioxidant activity with an IC50 value of 102,945 ppm.
Challenges towards selecting Saudi Arabia as an arbitral seat for foreign investors
Authors: Alsahli Abdulelah 
Published: July 2023

Abstract
Identifying the seat of arbitration jurisdiction is of great significance to the arbitral procedure. Countries seek to develop their arbitration laws and harmonize the cross-border arbitral regimes in order to modernize the practices and increase foreign direct investments nationally. Foreign parties aim to select an arbitral seat that is efficient and conforms to international arbitration practices. The parties’ choice of seat dictates the arbitral procedure adopted on the dispute and influences the boundaries of the arbitral awards. This paper evaluates Saudi Arabia as an arbitral seat for foreign investors and considers the key factors affecting the parties’ selection. Further, the paper analyses the legal barriers faced by the parties in association with selecting the Kingdom as a seat for arbitration. The purpose of the paper is to outline the challenges and present recommendations to develop the practices of arbitration in Saudi Arabia to increase its level of conformity to international arbitration standards.
Gastroprotective effect of the flavonoid fustin isolated from Cotinus coggygria heartwood in a rat model of indomethacin-induced gastric ulceration
Authors: Georgieva Antoaneta , Pavlov Danail , Tzaneva Maria , Novakovic Miroslav , Tesevic Vele , Reyzov Mehmed , Eftimov Miroslav , Todorova Milena , Nikolova Miglena , Stefanova Nadezhda , Valcheva-Kuzmanova Stefka 
Published: July 2023

Abstract
Gastric ulcer is a common health issue. Cotinus coggygria heartwood extracts rich in the flavonoids fustin and sulfuretin have shown protective effects in a rat model of indomethacin-induced gastric ulceration. Fustin itself has been protective in a rat model of ethanol-induced gastric ulcer. In the present study we aimed to reveal the effect of the flavonoid fustin isolated from Cotinus coggygria heartwood in a rat model of indomethacin-induced gastric ulceration.
Fustin was isolated from Cotinus coggygria heartwood and purified. The experiment was performed on 30 male Wistar rats allocated to three groups – Control, Indo and F10. F10 group was pretreated with fustin (10 mg/kg b.w. for 7 days). Rats were sacrificed and macroscopic, histopathological and immunohistochemical investigations of the stomachs were performed.
Indomethacin caused severe mucosal damage, proven by the macroscopic, microscopic and immunohistochemical gastric mucosa investigation. Fustin pretreatment slightly reduced the macroscopic indices for gastric damage (ulcer number, area, score and index), and significantly alleviated the severity of the microscopic indices (mucosal erosions, necrosis, hemorrhages and inflammation). In fustin-pretreated rats, the expression of NF-κB was reduced in comparison with indomethacin-treated animals.
In conclusion, fustin exerted a gastroprotective action in an indomethacin-induced gastric ulceration model, probably due to its anti-inflammatory activity.
Chemical composition and biologic activities of different preparations of Japanese quince (Chaenomeles japonica)
Authors: Moneva Klementina , Gancheva Silvia , Valcheva-Kuzmanova Stefka 
Published: July 2023

AbstractThe hectic pace of life and growing threat of cardiovascular, metabolic and neoplastic diseases highlight the demand for products with natural origin that could simultaneously be part of the balanced diet and improve human’s health. A promising finding in this respect is the Japanese quince – Chaenomeles japonica. It is an ancient plant with eastern origin, but the scientific knowledge about it has only recently started to build up.The aim of this review is to gather scientific data about chemical composition and biologic activities of Chaenomeles japonica and to provide an insight into the possible prophylactic and therapeutic applications of the plant. The gathered and summarized information concerning Japanese quince shows that preparations of different parts of the plant, especially fruits and leaves, possess biologic properties that could be of exceptional nutritional and medicinal value. Antiinflammatory, antiproliferative, antimicrobial, carbohydrate metabolism-modulating activities in in vitro studies as well as safety profile, influence on neuropsychology and behavior in animal models are discussed.This review outlines the prophylactic and therapeutic effects of Chaenomeles japonica, as well as the chemical composition that stands behind them, and aims to serve as a basis for further investigations of the medicinal plant’s potential.
Traditional Knowledge of Medicinal Plants in Relation to Local Customs and Practices of the North Black Sea Coast Population
Authors: Cherneva Djeni , Ivanov Dobri 
Published: July 2023

AbstractThis comprehensive ethnobotanical study was conducted along the North Black Sea coast area to find of the extent to which indigenous knowledge of medicinal plants and their relation to Bulgarian traditions and customs is preserved. We aim to identify the tendencies of passing this knowledge to future generations.The survey was conducted in 2015 in various urban and rural North Black Sea coast areas, using a face-to-face interviews technique. We used the Chi-square test to analyse the results. Pearson correlation coefficient was used for the assessment of the impact of demographics on respondents' answers.More than half of the respondents (61.08%) are not familiar with rituals and traditional practices related to medicinal plants. Moderate influence on respondents' answers is rendered by age only. For the local population of the North Black Sea coast, Enyovden turns out to be the most popular holiday related to medicinal plants. Enyovden is the herbalists' feast and is cited by 20% of respondents. The same percentage of interviewees mention Geranium spp. and Ocimum basilicum L. as the most favoured herbs related to local traditions and customs.Traditional knowledge of the relation between Bulgarian rituals and customs to medicinal plants and their magical powers is fading.
The Influence of 3D Printing Parameters on the Mechanical Properties of Reinforced PLA – A Review
Authors: Ilie Mihaela Feraru 
Published: July 2023

Abstract
Due to the multiple advantages of 3D printing, it is used in many industrial fields, from robotics to the food industry, from the automotive industry to the aerospace industry. The results in the paper refer to parts obtained by 3D printing (longitudinal and transverse) from PLA reinforced with wood fibers of 100%, 200% and 300% widths compared to the parts obtained by pressing. The behavior of reinforced parts of the PLA with wood fibers and a bio-additive were also studied. There were no noticeable differences in tensile strength when printing in the transverse direction from the parts obtained by pressing, and in the case of longitudinal printing the behavior is similar. Instead, there is a significant decrease in traction resistance to transverse printing compared to the longitudinal one. The variation in the width of the printed part influences the mechanical behavior in the sense that in the parts printed at 0° a more ductile behavior was recorded with its increase. The adhesion between wood fibers and matrix can be improved using a bioamide, and the addition of only 1.3% of the bio-additive led to an increase in traction resistance due to improved adhesion between wood fibers. There was also a slight increase in the rigidity of the parts due to the increase in Young’s module. The impact resistance was much higher in the case of notchless sample because, as is natural, they can absorb more energy compared to notched sample.
How Does Female Entrepreneurship Affect Happiness?
Authors: Chikh-Amnache Sabrina , Chikh-Boubaghela Nabila , Mekhzoumi Lotfi 
Published: July 2023

Abstract
The purpose of this paper is to investigate the correlation between female entrepreneurship and happiness within the Association of Southeast Asian Nations (ASEAN) region. The study uses a panel data model with two independent variables measuring female entrepreneurship and five control variables measuring the determinants of happiness. The method used for analysis is the panel fixed effects of the method of moments quantile regression (MM-QR) to examine data from nine ASEAN countries between 2006 and 2021. MM-QR can capture the location and scale of the conditional distribution of the dependent variable, making it suitable for studying the heterogeneous effects of female entrepreneurship on happiness across happiness quantiles. This approach controls for unobserved time-invariant heterogeneity, reducing omitted variable bias in cross-sectional studies. The MM-QR approach is rigorous and robust for analysing the complex relationship between female entrepreneurship and happiness in ASEAN countries. The main contribution of this study is to shed light on the relationship between female entrepreneurship and happiness, which reinforces and supports comprehensive development in emerging countries. The findings suggest that policymakers and practitioners can benefit from supporting female entrepreneurship by implementing policies and programs that provide access to education, training, mentorship, and financing. Furthermore, the study highlights the importance of the gender development index (GDI) as a determinant of happiness in ASEAN countries.
Renal lipid deposition and diabetic nephropathy
Authors: Yang Ming , Liu Yan , Luo Shilu , Xiao Ying , Zhao Chanyue , Sun Lin 
Published: July 2023

Abstract
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and the main cause of end-stage renal disease (ESRD). Lipid metabolism disorders are a common clinical manifestation of DN and are involved in the development of DN. Ectopic lipid deposition refers to lipids deposited in nonadipose tissue, such as liver, brain, skeletal muscle, and kidney. Recently, renal lipid deposition has been shown to play an important role in the pathological progression of DN. In this review, we summarize our understanding of the molecular mechanisms of renal lipid deposition and explore the relationship between renal lipid deposition and renal injury in DN.
Efficacy and safety of dual blockade of the renin-angiotensin-aldosterone system in diabetic kidney disease: A meta-analysis
Authors: Zhang Yaling , Ren Song , Zhang Yuan , Wang Li , Li Guisen 
Published: July 2023

Abstract

Objective
To compare the relative efficacy and safety of dual blockade with sole blockade of the renin-angiotensin-aldosterone system in diabetic kidney disease.

Method
Studies were selected by searching the databases of MEDLINE, EMBASE, PubMed, and China National Knowledge Infrastructure (CNKI). All trials with angiotensin-converting enzyme inhibitor (ACEI) + angiotensin II type 1 (AT1) receptor blocker (ARB) (combination therapy), ACEI alone, or ARB alone (monotherapy) for treatment of diabetic kidney disease were included. The clinical parameters included for comparison were the progression to end-stage kidney disease (ESKD) or the outcomes of death, serum creatinine, glomerular filtration rate (GFR), serum potassium, 24-h urinary protein, urine albumin-to-creatinine ratio (UACR), urinary albumin excretion rate (UAER), and blood pressure.

Results
Twenty-two studies involving 6492 participants were eventually included. Compared to ACEI or ARB alone, a combination of ACEI and ARB can greatly reduce urine protein by 160 mg/d, the level of ACR significantly, as well as the systolic and diastolic blood pressures. The increase of serum creatinine and the decrease of GFR were more obvious in the combination treatment group. There was no significant difference in endpoint events between the two groups. The serum potassium level was significantly increased in the combination treatment group.

Conclusions
ACEI combined with ARB in the treatment of diabetic kidney disease can significantly reduce the level of proteinuria, decrease the blood pressure, and delay the progression of kidney disease. Moreover, it has some risk of increasing serum potassium and serum creatinine compared with monotherapy; so, careful attention is needed in dual blockade treatment.
Entaglement and communication in digital qubits using FPGAs
Authors: Hawargi Bhuvan , Akshay K B , Bhowmick Kaustav 
Published: July 2023

AbstractThis paper focuses on usage of digital qubits on a digital quantum computing platform implemented on FPGAs. Modifications have been made to existing digital qubit standards to account for complex probability amplitudes and not only real ones. This paper introduces an improved transient effect ring-oscillator based TRNG used in the scope of this project. The objective of this was to simulate the addition of environmental noise in a digital setting. Using the newly designed digital qubits, a few quantum logic gates have been designed to work on the FPGA platform using Verilog. These logic gates have then been used to implement entanglement on a digital hardware platform. Furthermore, this paper implements communication between two digital quantum computers over both wired and wireless media by transmitting alphabetical messages as qubits and compares the same with transmission involving classical digital bits only.
6G wireless system: The emerging trend in cellular technology
Authors: Sikiru Adegoke Adesoye , Olukayode Ajayi Abayomi , Lateef Otegbeye Adeyinka , Sobowale Soneye Olufemi 
Published: July 2023

Abstract
Cellular technology has brought about a significant revolution in the way we communicate and share information. In the last four (4) decades, researchers in the field of wireless cellular technology have been consistently upscaling their designs in tech space which has led to the evolutions of 1G, 2G, 3G, 4G and 5G in close successions. The most recent is 5G which is currently being implemented in various continents across the globe. 5G encompasses a technological framework that can support machine-to-machine (m2m) communication, virtual and augmented reality and smart manufacturing. However, its drawbacks are now coming into bare as its being deployed globally which suggests that 5G may not stand test of time beyond this decade. This has necessitated early research work into the evolution of next generation technology, the 6G. This paper therefore chronicles the emerging technologies in wireless cellular systems, their evolutionary trends, likely features and prospects of the next generation, the 6G.
Audit Committee’s Characteristics and the Cost of Debt
Authors: Santos Inês Borges , Pinto Inês , Morais Ana Isabel 
Published: July 2023

Abstract

Objective
This paper examines the association between audit committee characteristics and the cost of debt, with the aim of gaining new insights on how this corporate governance mechanism contributes to the reduction of debt costs.

Methodology
Using a sample of FTSE 100 companies listed in 2018 and 2019, our study investigates how audit composition and characteristics, such as financial and industry expertise, gender, tenure and diligence affect audit committees’ oversight role, and therefore the impact on the companies’ level of risk and the cost of debt.

Findings
The results show that overall audit committee’s characteristics do not impact the corporate cost of debt, except for the gender of the audit committee’s chair. Companies with audit committees managed by a chairwoman experience a lower cost of debt. The results also confirm that external auditors influence the cost of debt. As additional test, we conducted a principal component analysis to construct a corporate governance index of audit committee´s characteristics, and we obtained similar results. Overall, the study results seem to suggest that the cost of debt is more significantly influenced by external auditors than by the characteristics of the audit committee.

Value Added
This paper contributes to the literature on corporate governance by showing how audit committees characteristics affect the cost of debt.

Recommendations
This study improves the understanding of the way debtholders may assess audit committee’s characteristics and auditors when assessing companies’ financial risk and the corporate cost of debt.
The Efficiency of Sustainability Engagement Reported by Banks in Poland, Croatia and Romania
Authors: Fijałkowska Justyna , Sačer Ivana Mamić , Zyznarska-Dworczak Beata , Sandulescu Maria-Silvia , Garsztka Przemysław , Mokošova Daša 
Published: July 2023

Abstract

Purpose
This study aims to verify the efficiency of economic, organisational, social and environmental dimensions of sustainability performance.

Methodology
Disclosure analysis and 2-stage data envelopment analysis (DEA) examining the efficiency of sustainability engagement of listed banks in Poland, Croatia, and Romania disclosed in the annual and CSR/sustainability reports for 2015–2018.

Findings
There are apparent differences between the efficiency of sustainability engagement in the banking sectors of the three countries examined in the study. Banking sectors in all these countries are on different stages of their paths to value creation via the efficiency of sustainability engagement.

Practical implications
The results of this study may help compare sustainability engagement and understanding of the further directions of sustainable development in the banking sector in both the analysed and other countries, as well as in other institutions from other sectors. These results may be important for the decision-makers in determining the actions focused on improving efficiency on the way to value creation.

Originality/value
Since only a limited number of studies examine the efficiency of sustainability engagement, especially in CEE countries, little is known about value creation, understood as the efficient use of the resources and activities concerning sustainability. This paper contributes to filling in this gap. It also proposes an alternative approach, analysing the relationship between sustainability engagement and value creation based on efficiency rather than on the direct impact on financial results giving ambiguous results. This approach may be extended to different sectors and other countries.