bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prescribing and deprescribing trends in schizophrenia: An overview of inpatients in Belgium and in the Canadian province of Québec
Authors: Lagreula Juliette , Dagenais‐Beaulé Vincent , de Timary Philippe , Elens Laure , Dalleur Olivia 
Published: March 2023

AbstractAlthough switching to antipsychotic monotherapy improves patient outcomes in schizophrenia, antipsychotic deprescribing is rarely performed, and its use varies between countries, as do psychotropic prescribing patterns. This study aimed to determine factors associated with antipsychotic deprescribing at discharge after a psychiatric hospitalization and to compare psychotropic prescribing patterns between Belgium and Québec, Canada. Data on adult inpatients with schizophrenia were collected retrospectively in seven hospitals. At discharge, the number of antipsychotics had decreased in 22.2% of the 63 Canadian patients and 9.9% of the 516 Belgian patients. A number of factors increased the likelihood of antipsychotic deprescribing: a hospitalization in the Canadian hospital (aOR = 4.13, 95% CI 1.48–11.5), living in a residential facility (aOR = 2.51, 95% CI 1.05–4.39), ≥2 previous antipsychotic trials (aOR = 15.38, 95% CI 3.62–65.36), having an antipsychotic side effect (aOR = 1.86, 95% CI 1.01–3.44) and being in a general hospital (aOR = 2.28, 95% CI 1.09–4.75). Patients on a long‐acting injectable antipsychotic (aOR = 0.51, 95% CI 0.26–0.98), with prior clozapine use (aOR = 0.36, 95% CI 0.13–0.95), greater antipsychotic exposure (aOR = 0.35, 95% CI 0.2–0.61) and more hypno‐sedatives (aOR = 0.65, 95% CI 0.43–0.98), were less likely to be deprescribed. Specific deprescribing interventions could target patients who are less likely to be deprescribed.
The impact of preferential trade agreements on the duration of antidumping protection
Authors: Zhu Min , Prusa Thomas J. 
Published: March 2023

AbstractThis paper examines the impact of preferential trade agreements on the duration of antidumping protection. We employ a two‐step selection model where the first step accounts for the impact of membership in a preferential trade agreement on the original antidumping determination and the second step estimates the impact of membership in a preferential trade agreement on the duration of the measures. We find the duration of antidumping protection is about 17% shorter for preferential trade agreement members compared with targeted countries that are not preferential trade agreement members. The impact on duration depends largely on whether preferential trade agreements have rules related specifically to antidumping. Preferential trade agreements with rules are associated with a 28% reduction in the duration of protection, whereas the duration for preferential trade agreements without rules is not statistically different from the duration for non‐preferential trade agreement countries. While the duration of antidumping measures against China is longer than for other countries, the impact of preferential trade agreement rules is robust to controlling for China.
Molecular targets of metformin against ovarian cancer based on network pharmacology
Authors: Guo Jia‐yi , Wang Yong‐jun , Li Si‐qi , Wu Yu‐ping 
Published: March 2023

AbstractThe objective of this study was to analyze potential targets of metformin against ovarian cancer (OC) through network pharmacology. Pharmacodynamic targets of metformin were predicted using the Bioinformatics Analysis Tool for the molecular mechanism of traditional Chinese medicine (BATMAN), Drugbank, PharmMapper, SwissTargetPrediction, and TargetNet databases. R was utilized to analyze the gene expression of OC tissues, normal/adjacent noncancerous tissues, and screen differentially expressed genes (DEGs) in the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) + Genotype‐Tissue Expression (GTEx) datasets. STRING 11.0 was utilized to explore the protein–protein interaction (PPI) of metformin target genes differentially expressed in OC. Cytoscape 3.8.0 was used to construct the network and screen the core targets. Additionally, gene ontology (GO) annotation and enrichment and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed for the common targets of metformin and OC through the DAVID 6.8 database. A total of 95 potential common targets of metformin and OC were identified from the intersection of 255 potential pharmacodynamic targets of metformin and 10,463 genes associated with OC. Furthermore, 10 core targets were screened from the PPI network [e.g., interleukin (IL) 1B, KCNC1, ESR1, HTR2C, MAOB, GRIN2A, F2, GRIA2, APOE, PTPRC]. In addition, it was shown in GO enrichment analysis that the common targets were mainly associated with biological processes (i.e., response to stimuli or chemical, cellular processes, and transmembrane transport), cellular components (i.e., plasma membrane, cell junction, and cell projection), and molecular functions (i.e., binding, channel activities, transmembrane transporter activity, and signaling receptor activities). Furthermore, it was indicated by KEGG pathway analysis that the common targets were enriched in metabolic pathways. The critical molecular targets and molecular pathways of metformin against OC were preliminarily determined by bioinformatics‐based network pharmacology analysis, providing a basis, and reference for further experimental studies.
Head and neck cancer: A 6‐year retrospective analysis and review of three common triaging systems
Authors: Siddiqui Zohaib , Hamid Mohammed , Caton Nadine , Cheang Pei‐Pei 
Published: March 2023

AbstractObjectivesIn the United Kingdom, head and neck cancer (HNC) cases continue to rise and are the fourth commonest cancers in men. Additionally, in the last decade, the incidence rise in women is twice their male counterpart, signifying the need for robust and dynamic triaging systems to maintain high pick‐up rates across both genders. This study investigates local risk factors associated with HNC and reviews the most commonly used guidelines and risk calculator tool for two‐week‐wait (2ww) HNC clinics.DesignSix‐year retrospective case–control analysis of 2ww HNC clinics within a district general hospital in Kent studying symptoms and risk factors.ResultsTwo hundred cancer patients (128M:72F) were identified and compared against 200 randomised non‐cancer patients (78M:122F). Increasing age, male gender, smoking, previous cancer and neck lumps were statistically relevant risk factors for HNC (p < .001). HNC mortality at 1 and 5 years was 21% and 26%, respectively. Adjusting guidelines to improve local services obtained the following area under curve (AUC) scores: NICE guidelines 67.3, Pan‐London 58.0 and HNC risk calculator version 2 (HaNC‐RC V.2) 76.5. Our adjusted HaNC‐RC V.2 improved sensitivity by 10% to 92%, and theoretically reduces local general practice referrals by 61% when utilising triaging staff.ConclusionOur data portray the primary risk factors as increasing age, male gender and smoking for this demographic. The presence of a neck lump was the most significant symptom within our cohort. This study demonstrates a critical balance when adjusting sensitivity and specificity of guidelines and proposes that departments adjust diagnostic tools for their local demographic to improve referral numbers and patient outcomes.
Multiparametric magnetic resonance imaging: A robust tool to test pathogenesis and pathophysiology behind nephropathy in humans
Authors: Andersen Ulrik B. , Haddock Bryan , Asmar Ali 
Published: March 2023

AbstractChronic kidney disease (CKD) is a major population disease. In diabetes as well as hypertension, kidney disease is one of the most serious complications. Recent research has demonstrated that chronic hypoxia is a key actor in the pathogenesis of CKD. In this review, we focus on how functional magnetic resonance imaging (fMRI) techniques can shed light on pathogenetic mechanisms and monitor new treatments aimed at preventing or ameliorating the disease. Multiparametric MRI techniques can measure changes in renal artery flow, tissue perfusion, and oxygenation repetitively over short time periods, enabling high time resolution. Furthermore, renal fibrosis can be quantified noninvasively by MRI diffusion tensor imaging, and techniques are upcoming to measure renal oxygen consumption. These techniques are all radiation and contrast‐free.We briefly present data, demonstrating that fMRI techniques can play a major role in future research in CKD, and possibly also in daily clinical practice.
A global analysis of avian island diversity–area relationships in the Anthropocene
Authors: Matthews Thomas J. , Wayman Joseph P. , Whittaker Robert J. , Cardoso Pedro , Hume Julian P. , Sayol Ferran , Proios Konstantinos , Martin Thomas E. , Baiser Benjamin , Borges Paulo A. V. , Kubota Yasuhiro , dos Anjos Luiz , Tobias Joseph A. , Soares Filipa C. , Si Xingfeng , Ding Ping , Mendenhall Chase D. , Sin Yong Chee Keita , Rheindt Frank E. , Triantis Kostas A. , Guilhaumon François , Watson David M. , Brotons Lluís , Battisti Corrado , Chu Osanna , Rigal François 
Published: March 2023

AbstractResearch on island species–area relationships (ISAR) has expanded to incorporate functional (IFDAR) and phylogenetic (IPDAR) diversity. However, relative to the ISAR, we know little about IFDARs and IPDARs, and lack synthetic global analyses of variation in form of these three categories of island diversity–area relationship (IDAR). Here, we undertake the first comparative evaluation of IDARs at the global scale using 51 avian archipelagic data sets representing true and habitat islands. Using null models, we explore how richness‐corrected functional and phylogenetic diversity scale with island area. We also provide the largest global assessment of the impacts of species introductions and extinctions on the IDAR. Results show that increasing richness with area is the primary driver of the (non‐richness corrected) IPDAR and IFDAR for many data sets. However, for several archipelagos, richness‐corrected functional and phylogenetic diversity changes linearly with island area, suggesting that the dominant community assembly processes shift along the island area gradient. We also find that archipelagos with the steepest ISARs exhibit the biggest differences in slope between IDARs, indicating increased functional and phylogenetic redundancy on larger islands in these archipelagos. In several cases introduced species seem to have ‘re‐calibrated’ the IDARs such that they resemble the historic period prior to recent extinctions.
Song overlapping and matching during low‐arousal singing and their relation to visual ornaments, parental care and breeding success in the great tit (Parus major)
Authors: Bircher Nina , Mennill Daniel J. , van Oers Kees , Naguib Marc 
Published: March 2023

AbstractEavesdropping on interactions between conspecific animals provides a low‐cost method for assessing other individuals. Asymmetries in territorial counter‐singing interactions in songbirds provide a rich source of information for eavesdroppers about differences between the singers. Yet, little is known about the relationship between interactive singing in a natural, low‐arousal context among territorial neighbours and individual traits of males. We used a microphone array to monitor natural counter‐singing interactions in great tits (Parus major) during nest building, at the onset of the breeding season. We quantified song overlapping and song matching for 30 pairs (dyads) of interacting males, singing at their nest, respectively. We then compared these behaviours to five traits for 28 males: body condition, plumage ornamentation, offspring provisioning behaviour, offspring weight and breeding site quality. We found no relationship between a male song overlapping or matching behaviour and any of the measured traits. Therefore, our results do not support the idea that short‐term asymmetries in low‐arousal long‐range singing interactions among neighbours reflect differences in these fitness‐related traits. Instead, our findings suggest that such singing asymmetries have less signal value in the absence of an immediate conflict but instead reflect short‐term motivational differences, as shown in previous investigations.
Plant–herbivore interactions: Experimental demonstration of genetic variability in plant–plant signalling
Authors: Estarague Aurélien , Violle Cyrille , Vile Denis , Hany Anaïs , Martino Thibault , Moulin Pierre , Vasseur François 
Published: March 2023

AbstractPlant–herbivore interactions mediated by plant–plant signalling have been documented in different species but its within‐species variability has hardly been quantified. Here, we tested if herbivore foraging activity on plants was influenced by a prior contact with a damaged plant and if the effect of such plant–plant signalling was variable across 113 natural genotypes of Arabidopsis thaliana. We filmed the activity of the generalist herbivore Cornu aspersum during 1 h on two plants differing only in a prior contact with a damaged plant or not. We recorded each snails' first choice, and measured its first duration on a plant, the proportion of time spent on both plants and leaf consumption. Overall, plant–plant signalling modified the foraging activity of herbivores in A. thaliana. On average, snails spent more time and consumed more of plants that experienced a prior contact with a damaged plant. However, the effects of plant–plant signalling on snail behaviour was variable: depending on genotype identity, plant–plant signalling made undamaged plants more repellant or attractive to snails. Genome‐wide associations revealed that genes related to stress coping ability and jasmonate pathway were associated to this variation. Together, our findings highlight the adaptive significance of plant–plant signalling for plant–herbivore interactions.
Presentation and management of advanced occlusal caries affecting the maxillary cheek teeth of four horses
Authors: Schneider Johanna , Reardon Richard J. M. , Pearce Chris J. , du Toit Nicole 
Published: March 2023

SummaryThis case series describes the management of advanced occlusal caries of the maxillary cheek teeth in four horses. All horses presented with grade 4 caries, i.e., affecting cementum, enamel, dentine and the integrity of the tooth. Food packing in deep cavities on the occlusal surface were present in all horses. Two horses presented with pulpitis of teeth adjacent to the occlusal caries lesions. The carious lesions were mostly limited to the occlusal surface of maxillary cheek teeth, whereas the peripheral cementum to a large degree remained unaffected. Management of these cases included cleaning, flushing, and debriding of carious surfaces and placing a flowable resin composite on areas with extensive tooth loss to prevent food packing and further destruction of dental tissues. Endodontic therapy was performed in two cases. Some of the horses that exhibited clinical signs showed improvement after treatment and none of the cases showed deterioration of caries lesions. One horse showed complete resolution of occlusal caries.
Study on the global stress field of the rock mass under compression and shear considering three kinds of crack parameters
Authors: Zhu Fengjin , Zhu Jiancai , Liu Fushen , Liu Hongyan 
Published: March 2023

AbstractThe mechanical behavior of the cracked rock mass is controlled by the crack initiation and propagation under compression and shear. The key to predicting the wing crack initiation angle is to correctly describe the distribution of the stress field at the crack tip. First, the previous studies are reviewed, and their inadequacies are discussed in detail. Next, according to the experimental results, three kinds of crack parameters (i.e., geometry, strength, and deformation) are introduced, and a stress transfer model on the crack face under compression and shear considering crack parameters is proposed. Then, the relevant formulae of stress intensity factors (KI and KII) and non‐singular term (T‐stress) at the crack tip are obtained. Finally, the proposed model is verified by other researchers' test results, and the effects of three kinds of crack parameters and the rock property on the distribution of tangential stress at the crack tip are discussed.
Feelings of being socially excluded: A matter of education, labour market situation, income, deprivation, or other things?
Authors: Hansen Hans‐Tore 
Published: March 2023

AbstractThis article aims (1) to investigate whether immigrants in the Norwegian population and their descendants differ in their feelings of being socially excluded from society compared with others born in Norway (‘natives’), and (2) to test empirically whether these differences reflect differences in human and economic capital (i.e., education, work, income, and material deprivation) and factors related to minority/majority issues, such as citizenship. The data were drawn from the Norwegian part of the European Union Statistics on Income and Living Conditions survey. The results show that immigrants—especially from Asia, Africa, Latin America, Oceania, non‐EU European countries, and descendants of immigrants—feel more socially excluded than natives. For immigrants from Africa, Asia, et al., and Europe other countries, human and economic capital are linked to these differences. Immigrants from Europe other countries did not differ from natives when adjusting for education and work. Differences between natives and immigrants from Africa, Asia, et al. and descendants of immigrants remained even after controlling for various factors. The study indicates that immigrants from outside the Nordic countries with secondary education feel socially excluded to a higher degree than other immigrants. One reason could be that they may have skills not recognised in the Norwegian labour market. The study also finds that immigrants with Norwegian citizenship feel less excluded from society than other immigrants. Length of stay and social recognition are possible explanations for these results.
An integer linear programming model for the label printing problem
Authors: Xu Dehua , Shen Yuan , Cao Yu , Xu Limin , Yang Fengzhao , Xie Yunzhou 
Published: March 2023

AbstractIn a recent paper published in this journal, Alonso‐Pecina et al. collect several sets of benchmark instances for the label printing problem from the literature and they also propose their own instances. Due to the intractability of the problem, no optimal solutions were declared for most of these instances. In this paper, we propose an integer linear programming model for the problem. We obtain optimal solutions or show that the solutions provided in the literature are already optimal for most of these instances based on the model. For some of the rest instances, we provide better solutions compared to the previous best solutions in the literature.
What constitutes an excellent literature review? Summarize, synthesize, conceptualize, and energize
Authors: Ketchen David J. , Craighead Christopher W. 
Published: March 2023

AbstractA literature review chronicles conceptual and empirical achievements within a research stream. An excellent literature review accomplishes much more. Excellent literature reviews not only explain advances within a research stream (“summarize and synthesize”) but also provide a conceptual framework that captures the key elements of the research (“conceptualize”) and lay a foundation for future inquiry that can accelerate progress in advancing knowledge (“energize”). We accomplish two main tasks in this editorial. First, we offer details about what constitutes an excellent literature review. Second, we summarize the four literature reviews contained in this special topic forum and explain their excellent features.
Using managers' expectations for ex‐ante policy evaluation: Evidence from the COVID‐19 crisis
Authors: Kawaguchi Kohei , Kodama Naomi , Kumanomido Hiroshi , Tanaka Mari 
Published: March 2023

AbstractEvaluation of the impacts of government policies during an economic crisis is often delayed until the outcomes are realized. Policies can be better guided if they can be evaluated amid a crisis, before the realization of outcomes. This study examines whether survey data on the expectations of small business managers can help evaluate two high‐stake subsidies for firms amid the COVID‐19 crisis in Japan, namely, Subsidy Program for Sustaining Businesses (SPSB) and Employment Adjustment Subsidy (EAS). We evaluate the accuracy of managers' expectations, estimate the impact of subsidies on the expected firm survival, and compare it with the estimated impact on realized survival. We find that the managers' expectations on their future sales, survival rate, and the possibility of receiving these subsidies predict the realized outcomes, although they were highly pessimistic about their survival rates. We find that the estimated impacts of the SPSB on the expected survival rates have the same sign as the estimated impact on the realized survival rates, but the size is more than twice because of the pessimism on survival. The estimated impacts of the EAS are both insignificant. Therefore, although its impact may be overestimated, managers' expectations are useful for selecting an effective policy.
How firms compete when they set identical prices: Nonprice strategies in the Indian biscuit industry
Authors: Antonecchia Gianluca , Bhaskarabhatla Ajay 
Published: March 2023

AbstractHow do firms compete when all firms in an industry set identical prices? Using Nielsen data on India's biscuit manufacturers, we document productivity‐based competition on nonprice strategies under industry‐wide uniform pricing. Products with one standard deviation higher quantity‐based productivity contain, on average, 13% more quantity per pack for the same price. Productivity also positively correlates with promotions on pack size, availability, and variety. A higher price (per pack size) sensitivity in rural markets combined with industry‐wide uniform pricing imposes a greater burden on rural consumers. Additional analyses show that firms can reduce this burden by selling different pack sizes in urban and rural areas.
Genomic characterization and identification of virulence‐related genes in Vibrio nigripulchritudo isolated from white leg shrimp Penaeus vannamei
Authors: Rathnapala Jayasundara Mudiyanselage Sajani Nisansala , Ragab Wafaa , Kawato Satoshi , Furukawa Miho , Nozaki Reiko , Kondo Hidehiro , Hirono Ikuo 
Published: March 2023

AbstractVibrio nigripulchritudo causes vibriosis in penaeid shrimps. Here, we used Illumina and Nanopore sequencing technologies to sequence the genomes of three of its strains (TUMSAT‐V. nig1, TUMSAT‐V. nig2, and TUMSAT‐V. nig3) to explore opportunities for disease management. Putative virulence factors and mobile genetic elements were detected while evaluating the phylogenetic relationship of each isolated strain. The genomes consisted of two circular chromosomes (I and II) plus one or two plasmids. The size of chromosome I ranged from 4.02 to 4.07 Mb with an average GC content of 46%, while the number of predicted CDSs ranged from 3563 to 3644. The size of chromosome II ranged from 2.16 to 2.18 Mb, with an average GC content of 45.5%, and the number of predicted CDSs ranged from 1970 to 1987. Numerous virulence genes were identified related to adherence, antiphagocytosis, chemotaxis, motility, iron uptake, quorum sensing, secretion systems, and toxins in all three genomes. Higher numbers of prophages and genomic islands found in TUMSAT‐V. nig1 suggest that the strain has experienced numerous horizontal gene transfer events. The presence of antimicrobial resistance genes suggests that the strains have multidrug resistance. Comparative genomic analysis showed that all three strains belonged to the same clade.