bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing electro-generated excitons for tunable lanthanide nanocrystal electroluminescence
Authors: Liu Xiaogang , Tan Jing , Song Xiaoqing , Han Chunmiao , Wang Feng , Zhang Jing , Duan Chunbo , Han Sanyang , Xu Hui 
Published: January 2025

Abstract

Lanthanide nanocrystals are promising candidates for electrically powered light-emitting diodes (LEDs) due to their narrow-band emission, high color purity, and broad color turnability. However, their insulating nature poses a challenge for carrier transport and injection, impeding their application in optoelectronic devices. Here we demonstrate efficient electroluminescence from insulating lanthanide fluoride nanocrystals (5 nm; NaGdF4:Tb3+ or NaGdF4:Eu3+) coated with a series of functionalized 2-(diphenylphosphoryl)benzoic acids (ArPPOA). These ligands, featuring donor-phosphine oxide acceptor hybrids with carboxyl and P=O coordination sites, effectively sensitize the luminescence of lanthanide nanocrystals. By modulating the intensity of intra-ligand charge transfer, the first singlet (S1) and triplet (T1) energy levels of ArPPOA are precisely adjusted to optimize intersystem crossing (ISC), reverse ISC, and the interplay between singlet Förster resonance energy transfer and triplet Dexter energy transfer to the nanocrystals. Through careful control of dopant composition and concentration in nanocrystals, we also achieve wide-ranging multicolor electroluminescence without altering the device architecture, reaching an external quantum efficiency exceeding 5% for Tb3+. This ligand-functionalized nanocrystal platform provides a versatile and efficient approach for realizing wide-band tunable electroluminescent emissions.
Large-Scale Crossbar Arrays based on Three-Terminal MoS2-based Memtransistors
Authors: Das Saptarshi , Schranghamer Thomas , Pannone Andrew , Chen Chen , McKnight Thomas , Tadekawa Sean , Haines Evan , Ordonez Richard Ordonez , Hayashi Cody , Redwing Joan 
Published: January 2025

Abstract

Memristive crossbar architectures are promising as efficient, low-power inference engines for edge AI applications. However, inputs with minor differences often yield similar outputs, requiring additional processing methods such as confidence scoring, feedback mechanisms, crossbar redundancy, or hybrid analog-digital approaches to resolve. These methods can be impractical for resource-limited edge devices. In contrast, three-terminal memtransistors can dynamically tune conductance via gate control, effectively resolving similar outputs and enhancing separability without retraining. Here, we present dense, large-scale crossbar array architectures incorporating up to 2048 MoS2 memtransistors per array, achieving >92% yield across multiple arrays. These architectures demonstrate the ability to resolve inference ambiguities through gate modulation without the need for costly retraining or reprogramming. We also validated their performance by successfully classifying handwritten digits from the MNIST database. Additionally, these memtransistors exhibit write energies as low as ~0.2 fJ, maintain read margins up to 10⁵, and offer long-term non-volatile retention exceeding three years. To the best of our knowledge this is the largest array-level demonstration based on 2D materials reported thus far in literature. Additionally, we benchmark the performance of MoS2 memtransistors against other 2D material-based architectures and project their potential compared to state-of-the-art AI accelerators.
A Case Report of Successful Pregnancy Following Salpingo-Uterine Body Transplantation
Authors: Yang Lin , Lin Xiaoqian , Abdah Md   , Habibah Abdul Hamid   
Published: January 2025

Abstract

Background
Proximal fallopian tube obstruction is a major cause of infertility in women. In cases where tubal surgery fails, assisted reproductive technologies (ART) such as in vitro fertilization (IVF) may be considered. However, a novel surgical procedure for addressing proximal fallopian tube obstruction via salpingo-uterine body transplantation is reported here.
Case Presentation:
A 35-year-old woman with bilateral proximal fallopian tube obstruction underwent a unique surgical procedure designed to restore fertility. The procedure involved the insertion of a double J stent through the vagina into the uterine cavity, with the creation of a new channel connecting the stent to the isthmus of the fallopian tube. Two months after the surgery, the patient successfully conceived and delivered a healthy boy via cesarean section. Post-delivery follow-up confirmed patency in the right fallopian tube.
Conclusion
This case demonstrates that salpingo-uterine body transplantation is a potential alternative treatment for proximal tubal obstruction, especially for patients who cannot afford IVF or wish to avoid ART. Further research is necessary to establish its broader clinical applicability.
In-situ Raman Investigation on the Phase Transition of Grunerite at High Pressure
Authors: Zheng Zhi , Zou Shaohao , Wu Chuanjun , Mei Shenghua 
Published: January 2025

Abstract
Amphiboles are key rock-forming minerals and play a significant role in the subduction process. Grunerite (Mg,Fe)7Si8O22(OH)2, as an important ferromagnesian amphibole, is known to undergo a phase transition from monoclinic C2/m to P21/m structure at elevated pressures. This study investigates the phase transition of grunerite under high pressure using a diamond anvil cell combined with in-situ Raman spectroscopy, aiming to identify pressure-induced phase transitions and associated structural changes. We have identified mode splits of the OH stretching modes indicative of the C2/m to P21/m phase transition at ∼1.46 GPa and observed another possible phase transition suggested by discontinuity in the OH modes at ∼17.81 GPa. The splitting of the OH stretching modes resulted from the distinct environments of two OH positions in the P21/m phase, in comparison to the crystallographically identical OH positions in the C2/m phase. We have also identified additional M–O modes in the lower-wavenumber spectrum range. The results provide new insights into the structural stability of grunerite under extreme geological conditions, contributing to a deeper understanding of metamorphic petrology and geodynamics.
Identification of Key Genes and Pathways in Lenvatinib-resistant Hepatocellular Carcinoma using Bioinformatic Analysis and Experimental Validation
Authors: Yang Ming , Wang Zhaoyue , Su Riga , Li Dongbing , Zhou Jun 
Published: January 2025

Background:
Resistance to lenvatinib poses a serious threat to the therapy of patients
with Hepatocellular Carcinoma (HCC). The mechanism by which HCC develops resistance
to lenvatinib is currently unknown.

Objective:
The aim of this study was to identify key genes and pathways involved in lenvatinib
resistance in HCC using bioinformatic analysis and experimental validation.

Methods:
Differentially expressed genes (DEGs) were identified from the GSE186191 gene
expression profile, comparing HCC cell lines with lenvatinib-resistant HCC cell lines. Gene
Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were then carried out using
DAVID. A protein-protein interaction network was constructed to visualize DEGs and
identify hub genes. The expression and prognostic significance of these hub genes were further
examined. Additionally, genomic enrichment analysis (GSEA) was utilized to investigate
the potential functions of key genes. Following this, the presence of AHSG was validated
in both the original Huh7 cells and the lenvatinib-resistant Huh7 (Huh7LR) cells resistant
to lenvatinib through the utilization of quantitative real-time PCR (qRT-PCR).

Results:
A total of 232 DEGs were identified between HCC cell lines and those that are resistant
to lenvatinib. These DEGs were significantly associated with arrhythmogenic right
ventricular cardiomyopathy, hypertrophic cardiomyopathy, dilated cardiomyopathy, and
mucin-type O-glycan biosynthesis. Three hub genes, including AHSG, C6, and ORM1,
were identified. The low expression of AHSG showed a poorer prognosis in HCC. GSEA
demonstrated a significant correlation between low AHSG expression and pathways involving
fatty acid metabolism, ribosome function, glycine, serine, and threonine metabolism, peroxisome
activity, and bile acid biosynthesis. The expression of AHSG was notably reduced
in Huh7LR cells (p = 0.006) compared to Huh7 cells.

Conclusion:
Diminished AHSG expression is strongly associated with lenvatinib resistance
in HCC, suggesting that it may have implications for developing effective strategies to overcome
this resistance.
FOLR1 Regulates the Malignant Progression of Glioblastoma through the SRC/ERK1/2 Axis
Authors: Jia Xueshan , Liang Weihang , Yang Junya , Chen Xuejiao , Bin Yi , Cao Zhikun , Tian Qingfeng 
Published: January 2025

Background:
GBM is an aggressive brain tumor with limited treatment options. Prior
research has indicated FOLR1 as a pivotal gene involved in cancer pathogenesis.

Aim:
This study aimed to explore the involvement of folate receptor alpha (FOLR1) in glioblastoma
(GBM) and evaluate its potential as a therapeutic target.

Objective:
This study investigated the expression pattern of FOLR1 in GBM, its impact on patient
prognosis, and its role in GBM cell growth and the SRC/ERK1/2 signaling axis.

Methods:
Initially, we conducted an expression analysis of FOLR1 based on public databases
and examined its expression pattern in GBM and its impact on patient prognosis. Subsequently,
cell experiments were carried out to evaluate the regulation of GBM cells by differential FOLR1
expression. We then downloaded 100 FOLR1 co-expressed genes from the Linkedomics data
repository and performed an enrichment analysis. Finally, the role of FOLR1 and SRC/ERK1/2
axis in GBM was analyzed again by cell experiments.

Results:
FOLR1 was found to be substantially expressed in GBM patients and was linked to a
poor prognosis. Cell experiments showed that overexpression of FOLR1 promoted GBM cell
growth, while low expression of FOLR1 inhibited cell growth. Additionally, genes related to
FOLR1 were enriched in the lysosome, toxoplasmosis, and other pathways. This study further
indicated that FOLR1 facilitates the activation of the SRC/ERK1/2 signaling pathway in GBM
cells, and the attenuation of these pathways can effectively impede the malignancy-promoting
effects triggered by FOLR1 in GBM cells.

Conclusions:
We revealed that FOLR1 orchestrates the malignant advancement of GBM by
stimulating the SRC/ERK1/2 signaling axis, underscoring its pivotal role in the pathogenesis of
GBM.

other:
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Niosomal Encapsulation of Anti-Cancer Peptides: A Revolutionary Strategy in Cancer Therapy
Authors: Patel Bhaveshkumar A. , Vashi Ankur , Borra Ramakrishna , Patel Mehul 
Published: January 2025

Abstract:
Cancer treatment has evolved significantly over the years, incorporating a range of
modalities including surgery, radiation, chemotherapy, and immunotherapy. However, challenges
such as drug resistance, systemic toxicity, and poor targeting necessitate innovative approaches.
Peptides have gained attention in cancer therapy due to their specificity, potency, and
ability to modulate various biological pathways. Peptide-based drugs can act as hormones, enzyme
inhibitors, or targeting ligands, contributing to their versatile role in cancer treatment.
However, peptides face several challenges, including instability, rapid degradation, and poor
bioavailability. One promising strategy is the use of niosomal delivery systems for peptidebased
therapies. Niosomes, which resemble liposomes in structure, are vesicles based on nonionic
surfactants. They are composed of a bilayer created through the self-assembly of non-ionic
surfactants in water, enabling them to encapsulate hydrophilic, lipophilic, and amphiphilic
drugs. Their unique properties, such as biocompatibility, biodegradability, and ability to encapsulate
diverse therapeutic agents, make them suitable for drug delivery applications. This review
aims to explore how the niosomal preparation of peptides can revolutionize oncology drugs by
overcoming critical challenges like drug resistance, systemic toxicity, poor targeting, instability,
rapid degradation, and low bioavailability. This review aims to explore how niosomes can specifically
address key limitations in cancer therapy, including targeting, bioavailability, and stability
of peptide-based drugs. By consolidating recent advancements, the review sheds light on
how niosomal encapsulation can overcome barriers in cancer treatment and improve therapeutic
outcomes for patients.
Dual Biological Effects and Mechanisms of Gut Microbiota in Breast Cancer: A Review
Authors: Ma Long , Liu Yuxin , Ning Mingliang , Ding Xiaoyun , Shang Chunyan , Mai Bin , Hu Zhiqiang , Zhou Ru 
Published: January 2025

Abstract:
Breast cancer (BC) is a common malignant tumor. BC is serious and has a high
mortality rate. The incidence of BC has increased in recent years. The incidence rate is higher
in coastal cities than in inland areas and in urban areas than in rural areas. Affect the occurrence
and development of BC, such as inflammation and immune response. One of the cutting-
edge studies to gain insight into the pathogenesis of BC is through the gut microbiota
(GM) influencing the health status of the human body. Advances in metabolomics analysis
can provide a clearer picture of changes in the composition of GM. The composition and
quantity of GM can affect the health of other parts of the body, and the disorder of GM can
lead to the occurrence and aggravation of diseases in different parts of the body. This paper
not only discusses the dual biological effects of GM on BC, the relationship between GM and
its metabolites, and BC and its related mechanisms but also explores traditional treatments for
BC as well as the treatment of BC through GM, providing theoretical support for the use of
methods to regulate GM in the clinical study of BC.
The Hormetic Potential of GDF15 in Skeletal Muscle Health and Regeneration: A Comprehensive Systematic Review
Authors: Tarchi Livio , Maiolini Gaia , Villa Gianluca , Rovero Paolo , Logu Francesco De , Nassini Romina , Garella Rachele , Sassoli Chiara , Ricca Valdo , Castellini Giovanni , Squecco Roberta 
Published: January 2025

Background:
Growth Differentiation Factor 15 (GDF15) has been described as
influencing skeletal physiology. Nevertheless, no systematic appraisal of the effect of GDF15 on
skeletal muscle tissues has been developed to the present day.

Objective:
The aim of the present work was to review the evidence on the topic.

Methods:
In this preregistered systematic review (https://osf.io/wa8xr), articles were retrieved
from MEDLINE/PubMed, EMBASE, and WebOfScience. Inclusion criteria comprised studies on
humans or animal models, assessment of peripheral or local tissue GDF15 concentrations, as
well as the direct expression of GDF15 in skeletal muscle, and direct or indirect correlates of
GDF15 with physical activity/ sarcopenia/trophism/ function.

Results:
A total of 646 studies were retrieved, and 144 finally included. Molecular inducers or
inhibitors of GDF15 in skeletal muscle tissues were described. GDF15 was reported to promote
skeletal muscle health, metabolic homeostasis, and overall physical conditioning. In pathology,
GDF15 seems to be correlated to the degree of muscle impairment and mitochondrial stress.
GDF15 has also been described as having the potential to stratify patients based on clinical
prognosis and functional outcome.

Conclusion:
A hormetic hypothesis for GDF15 on skeletal muscle was proposed. In fact, GDF15
exhibited beneficial effects when expressed at high levels facing acute stressors (i.e.,
“myoprotection”). Conversely, GDF15 exhibited maladaptive effects, such as chronic low-grade
inflammation, when chronically expressed in pathological processes (e.g., obesity, aging). GDF15
may be a potential molecular target for disease-modifying interventions. The current review
underscores the need for further research on GDF15 to elucidate its therapeutic potential across
different pathological states.
The study protocol, registered before data collection and analysis, can be retrieved at
https://osf.io/wa8xr. It should be noted that the study deviated from the protocol after peer review,
including other electronic databases beyond MEDLINE/PubMed alone.
Elucidating the Causal Dynamics between Inflammatory Proteins
and Atrial Fibrillation Risk Through Bidirectional Mendelian
Randomization
Authors: Lv Yuan , Huang Bin , Xu Liyin , Wu Xianjun 
Published: January 2025

Background:
Atrial fibrillation (AF), the most common cardiac arrhythmia, is
associated with significant morbidity and mortality. Inflammation has been implicated in
the pathogenesis of AF, but the causal relationship between specific inflammatory
proteins and AF risk is not well established. This study aims to clarify this relationship
using a bidirectional two-sample Mendelian Randomization (TSMR) approa

Methods:
Employing a bidirectional Mendelian Randomization (MR) method, we
analyzed genetic variants as instrumental variables (IVs) to investigate the influence of
91 circulating inflammatory proteins on AF risk. This approach allowed us to assess
the potential causal effects of inflammatory proteins on AF and vice versa, thus
providing a comprehensive understanding of the bidirectional nature of their
relationship.

Results:
Seven inflammatory proteins were significantly associated with AF risk.
Three proteins increased the risk: Fibroblast Growth Factor 5 (FGF-5) with an odds
ratio (OR) of 1.0743 (95% CI: 1.0466-1.1027, p=7.41E-08), Tumor Necrosis Factor
(TNF) with an OR of 1.0832 (95% CI: 1.0261-1.1434, p=0.0038), and Interleukin-2
Receptor Subunit Beta (IL-2RB) with an OR of 1.0814 (95% CI: 1.0151-1.1519,
p=0.0153). Four proteins showed a protective effect: CD40 Ligand Receptor (CD40)
with an OR of 0.9671 (95% CI: 0.9392-0.9959, p=0.0254), Fms-related Tyrosine
Kinase 3 Ligand (FIt3L) with an OR of 0.9553 (95% CI: 0.9173-0.9949, p=0.0274),
Leukemia Inhibitory Factor Receptor (LIF-R) with an OR of 0.9254 (95% CI: 0.8678-
0.9868, p=0.0181), and Sulfotransferase 1A1 (ST1A1) with an OR of 0.9461 (95% CI:
0.9097-0.9839, p=0.0056). The reverse MR analysis revealed no significant effects of
AF on the levels of these inflammatory proteins, suggesting a unidirectional causality
from proteins to AF.

Conclusion:
This bidirectional MR study provides robust evidence for a causal
relationship between specific inflammatory proteins and AF risk. The identified proteins
could serve as potential biomarkers for AF risk stratification and targets for therapeutic
intervention, offering new insights into the pathophysiology of AF and avenues for
future research.
Integrating Forensic Autopsies with Proteomic Profiling for Suicide Risk Assessment: A Comprehensive Review of Literature
Authors: Al-Habash Ibrahim H. , Alshaeb Asma Mahmoud , Srpanova Viktorija Belakaposka , Alempijevic Djordje , Keckarevic-Markovic Milica , Concato Monica , Radaelli Davide , D’Errico Stefano 
Published: January 2025

Background:
Suicide is a major global public health concern that affects people of all ages,
with over 700000 individuals intentionally ending their lives every year. Suicide is a multifactorial
event related to multiple risk factors interlocking with each other, among which neurobiological
factors are considered to be an objective measure of the incidence of this phenomenon and
can be used as a measurable tool for evaluating suicidal tendencies.

Objective:
The aim of this study is to thoroughly examine available data and assess candidate proteins
as prospective biomarkers for predicting suicides and ascertaining the manner of death in forensic cases.

Methods:
An electronic search was conducted on PubMed, Science Direct Scopus, and the Excerpta
Medica Database. The systematic review adhered to PRISMA guidelines and encompassed case series,
prospective and retrospective studies, and short communications published in English. The focus
was on proteomics and suicide, specifically, those studies where researchers conducted human
proteomic analyses on specimens obtained from individuals who completed or attempted suicide.

Results:
A total of 14 studies met the inclusion criteria, resulting in a dataset of numerous candidate
protein biomarkers. These include tenascin-C, potassium voltage-gated channel subfamily Q member
3, vimentin-immunoreactive astrocytes, glutathione S-transferase theta 1, iron transport proteins, Acrystallin
chain B, manganese superoxide dismutase, glial fibrillary acidic protein, various glycolytic
pathway proteins, 14-3-3 eta and 14-3-3 theta proteins, specific cytoskeleton proteins, C-reactive protein,
serum amyloid A protein 1, extrinsic coagulation pathway proteins, the vacuolar-type proton pump
ATPase subunit, plasma apolipoprotein A-IV, and ER stress proteins. These proteins are proposed as a
panel of biomarkers to be evaluated in conjunction with other clinical predictors of suicide.

Conclusion:
This review aims to provide a comprehensive summary of all proteomic studies conducted
on cases of attempted or completed suicide. By doing so, it seeks to bridge existing gaps in
knowledge and pave the way for future investigations. The ultimate goal is to potentially identify a
suicide biomarker.
Two Novel Peptides from Buthotus saulcyi Scorpion Venom: Proteomic
Analysis and Approaches
Authors: Zargan Jamil , Jahangirian Ehsan , Khan Haider A. , Ali Shakir 
Published: January 2025

Background and Objectives:
Venomous scorpions play a crucial role in medicine and
public health. Buthotus saulcyi scorpion is known as one of the most populous species in East Asia
and Iran, while its venom proteome has still not been fully determined.

background:
In the present study, we report for the first time a proteomic profile of Buthotus saulcyi scorpion venom with the aim of looking ahead and determining the structural and functional characteristics of these compounds for use as medical tools.

Aims:
In the current research, the proteomic profile of Buthotus saulcyi scorpion venom to determine
the structural and functional characteristics of its compounds used for treatment will be examined
for the first time.

objective:
In the present study, we report for the first time a proteomic profile of Buthotus saulcyi scorpion venom with the aim of looking ahead and determining the structural and functional characteristics of these compounds for use as medical tools.

Method::
2D-PAGE, HPLC, SDS-PAGE, sequencing, and MALDI-TOF MS techniques were used
to investigate the properties of these peptides.

Result:
The 2D-PAGE analysis of crude toxin from B. saulcyi revealed a minimum of 96 protein
spots, with isoelectric points ranging from 4 to 9 and molecular weights spanning from 3.6 to 205
kDa. Following this, HPLC was used to isolate 14 fractions of crude toxins, and the protein content
of these fractions was measured. SDS-PAGE analysis identified 7 protein bands within the B. saulcyi
crude toxin fractions, with molecular weights ranging from 13 to 217 kDa. Further examination
of fraction 7 through amino acid sequencing resulted in the identification of two protein bands labeled
peptide 3 and peptide 4. Ultimately, these protein bands were extracted, and their molecular
mass and amino acid sequences were analyzed using MALDI-TOF MS.

result:
2D-PAGE data from the B. saulcyi crude toxin showed at least 96 protein spots in isoelectric point between 4 and 9 and a molecular weight between 3.6 and 205 kDa. Then 14 fractions of crude toxins were isolated using HPLC and their protein content was estimated. SDS-PAGE analysis of fractions of B. saulcyi crude toxin showed 7 protein bands with a molecular weight between 13 and 217 kDa. Subsequently, the amino acid sequencing of Fraction 7 led us to two protein bands designated as Peptide 3 and Peptide 4 peptides. Finally, these protein bands were removed, and molecular mass and amino acid sequence analysis was performed using MALDI-TOF MS.

Conclusion::
According to our results, the alignment of P3 and P4 protein sequences revealed the
highest similarity to chrysophsin 2 and pheromone-bound protein 2, respectively.