bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond Numbers: An Ambiguity–Accessibility–Applicability Framework to Explain the Attraction Effect
Authors: He Sharlene , Sternthal Brian 
Published: February 2023

Abstract
The attraction effect (AE) occurs when the addition of an inferior alternative (i.e., a decoy) to a choice set increases the choice share of the alternative to which it is most similar (i.e., a target), a phenomenon that violates the regularity principle. The AE occurs reliably when the attribute values are represented numerically, but not when the stimuli are perceptual. Such conceptual replication failures indicate a lack of clarity about the mechanisms that produce the AE. The present research develops a framework—the 3A framework—that specifies the distinct functions of ambiguity, accessibility, and applicability in the choice process. These factors, and their attendant mechanisms, explain when and why the AE emerges. They also specify conditions under which the AE is attenuated. Seven main experiments and four supplementary experiments examine when and why the AE emerges with perceptual stimuli, provide support for the 3A framework, and offer insights about how to produce the AE in choice contexts involving perceptual stimuli.
Exploring Influencing Factors of Anxiety Improvement Following Mindfulness-Based Music Therapy in Young Adults with Cancer
Authors: Knoerl Robert , Mazzola Emanuele , Woods Heather , Buchbinder Elizabeth , Frazier Lindsay , LaCasce Ann , Luskin Marlise R , Phillips Carolyn S , Thornton Katherine , Berry Donna L , Ligibel Jennifer 
Published: February 2023

AbstractThe purpose of this secondary analysis was to explore physiological, psychological, and situational influencing factors that may affect the impact of a mindfulness-music therapy intervention on anxiety severity in young adults receiving cancer treatment. Young adults receiving cancer treatment for ≥ eight weeks were recruited from adult and pediatric oncology outpatient centers at Dana-Farber Cancer Institute. Participants were asked to attend up to four, in-person (offered virtually via Zoom video conference after the onset of the COVID-19 pandemic) 45-min mindfulness-based music therapy sessions over twelve weeks with a board-certified music therapist. Participants completed questionnaires about anxiety, stress, and other cancer treatment-related outcomes before and after participating in the intervention. Changes in anxiety (i.e., PROMIS Anxiety 4a) over time were compared among baseline physiological (e.g., age or sex), psychological (e.g., stress), and situational influencing (i.e., intervention delivery format) factors using Wilcoxon-rank sum tests. Thirty-one of the 37 enrolled participants completed the baseline and post-intervention measures and were eligible for inclusion in the secondary analysis. Results revealed that higher baseline physical functioning (median change = −6.65), anxiety (median change=-5.65), fatigue (median change = −5.6), sleep disturbance (median change = −5.6),&#x2028;female sex (median change = −5.15), or virtual intervention delivery&#x2028;(median change = −4.65) were potential physiological, psychological, or situational influencing factors associated with anxiety improvement following mindfulness-based music therapy. Additional investigation into physiological, psychological, or situational influencing factors associated with anxiety response will help to tailor the design of future mindfulness-music therapy interventions to decrease psychological distress and address the unique psychosocial concerns among young adults receiving cancer treatment.Trial Registration ClinicalTrials.gov Identifier: NCT03709225
Atrioventricular groove patch plasty in an infant with pulmonary stenosis after arterial switch operation: a case report
Authors: Nishiori Hironobu , Hagino Ikuo , Koshiyama Hiroshi , Ito Takahiro , Kumae Masaru , Aoki Mitsuru 
Published: February 2023

AbstractA 9-month-old infant developed pulmonary stenosis (PS) after an arterial switch operation for transposition of the great arteries, accompanied by a Shaher Type 4 coronary anatomy. As the right coronary artery (RCA) ran across the anterior side of the right ventricle (RV), atrioventricular (AV) groove patch plasty was performed to relieve PS. The distance between the RCA and tricuspid valve was confirmed by preoperative-computed tomography. The AV groove was carefully incised, ensuring the position of the tricuspid valve, and maintaining a distance of 3 mm from the tricuspid annulus to avoid approaching the RCA. While suturing the monocuspid valve patch, only the endocardial side of the RV was sutured, and RCA injury was prevented. Thus, especially in patients &lt; 1 year of age, careful incision of the AV groove and suturing only the endocardial side is important to avoid injuring the RCA in AV groove patch plasty.
Ascorbic acid-mediated reactive oxygen species homeostasis modulates the switch from tapetal cell division to cell differentiation in Arabidopsis
Authors: Wu Si-Yuan , Hou Ling-Li , Zhu Jun , Wang Yi-Chen , Zheng Yu-Ling , Hou Jian-Qiao , Yang Zhong-Nan , Lou Yue 
Published: February 2023

Abstract
The major antioxidant L-ascorbic acid (AsA) plays important roles in plant growth, development, and stress responses. However, the importance of AsA concentration and the regulation of AsA metabolism in plant reproduction remain unclear. In Arabidopsis (Arabidopsis thaliana) anthers, the tapetum monolayer undergoes cell differentiation to support pollen development. Here, we report that a transcription factor, DEFECTIVE IN TAPETAL DEVELOPMENT AND FUNCTION 1 (TDF1), inhibits tapetal cell division leading to cell differentiation. We identified SKEWED5-SIMILAR 18 (SKS18) as a downstream target of TDF1. Enzymatic assays showed that SKS18, annotated as a multicopper oxidase-like protein, has ascorbate oxidase activity, leading to AsA oxidation. We also show that VITAMIN C DEFECTIVE1 (VTC1), an AsA biosynthetic enzyme, is negatively controlled by TDF1 to maintain proper AsA contents. Consistently, either knockout of SKS18 or VTC1 overexpression raised AsA concentrations, resulting in extra tapetal cells, while SKS18 overexpression in tdf1 or the vtc1-3 tdf1 double mutant mitigated their defective tapetum. We observed that high AsA concentrations caused lower accumulation of reactive oxygen species (ROS) in tapetal cells. Overexpression of ROS scavenging genes in tapetum restored excess cell divisions. Thus, our findings demonstrate that TDF1-regulated AsA balances cell division and cell differentiation in the tapetum through governing ROS homeostasis.
The Other Insiders: Personal Trading by Brokers, Analysts, and Fund Managers
Authors: Berkman Henk , Koch Paul , Westerholm P Joakim 
Published: February 2023

Abstract
When brokers, analysts, and fund managers buy or sell stocks for their own accounts, these “access employees” of financial institutions outperform retail investors over short windows up to a month. They earn particularly high abnormal returns when they trade before earnings announcements, revisions of analyst recommendations, and large stock price changes. We also find evidence consistent with profitable front-running and information leakage around the execution of corporate insider trades and block trades by mutual funds, as well as the release of revised recommendations by analysts who work at the same brokerage firm. (JEL G12, G14, G18)
Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
A viscoelastic alginate-based hydrogel network coordinated with spermidine for periodontal ligament regeneration
Authors: Zhang Songbai , Jia Yuanbo , Liu Jingyi , Feng Fan , Wei Zhao , Zhang Min , Xu Feng 
Published: February 2023

AbstractPeriodontitis can cause irreversible defects in the periodontal ligament (PDL), the regeneration of which is the major obstacle to the clinical treatment of periodontitis. Implanting hydrogel for releasing anti-inflammatory drugs is a promising treatment to promote PDL regeneration. However, existing hydrogel systems fail to mimic the typical viscoelastic feature of native periodontium, which may have been shown as an important role in tissue regeneration. Meanwhile, the synergistic benefits of mechanical cues and biochemical agents for PDL regeneration remain elusive. In this study, we developed a bi-crosslinking viscoelastic hydrogel (Alg-PBA/Spd) by integrating phenylboronic acid-modified alginate with anti-inflammatory agent (spermidine) through borate ester and B–N coordination bonds, where spermidine will be released with the degradation of the hydrogel. Alg-PBA/Spd hydrogel is biocompatible, injectable and can quickly adapt to complex periodontal structures due to the dynamic crosslinking. We demonstrated in rat models that the viscoelastic Alg-PBA/Spd hydrogel significantly promotes the deposition of periodontal collagen and accelerates the repair of periodontal damage. Our results suggest that the viscoelastic Alg-PBA/Spd hydrogel would be a promising mechano-biochemically synergistic treatment for periodontal regeneration.
FACTORS INFLUENCING FLUOROSCOPY TIME IN ENDOVASCULAR TREATMENT OF ABDOMINAL ANEURYSMS: A RETROSPECTIVE STUDY
Authors: Efthymiou Fotios O , Kakkos Stavros K , Metaxas Vasileios I , Dimitroukas Christos P , Moulakakis Konstantinos G , Papadoulas Spyros I , Kouri Natasa K , Tsimpoukis Andreas L , Nikolakopoulos Konstantinos M , Papageorgopoulou Chrysanthi P , Panayiotakis George S 
Published: February 2023

Abstract
Patients who undergo endovascular aortic aneurysm repair (EVAR) may require prolonged radiation exposure affected by several factors. The objectives of this study were to document fluoroscopy time (FT) during EVAR and identify possible factors that influence it. A retrospective analysis of a 180 patients’ database with abdominal infrarenal aortic aneurysms submitted to EVAR during a 7-y period was performed. The FT is evaluated regarding risk factors and comorbidities, graft type and patient-related, clinical and technical parameters. FT’s median (interquartile range) was 1011 (698–1500) s. Excluder and C3 Excluder were associated with significantly lower FT values when compared with other grafts. Hypertension, dyslipidemia, age ≥ 70 y, maximum aneurysm diameter ≥ 6 cm and procedure duration ≥2 h resulted in higher FT values. A significantly lower FT was found for the operations performed in the 7th y of the study’s period compared with the previous 6 y, mainly because of the use of Excluder or C3 Excluder grafts. However, these grafts did not show any significant difference in FT values during the 7 y. A significant correlation between FT with age and procedure duration was found. Nevertheless, procedure duration is a poor FT predictor in linear and logistic regressions, although is significantly correlated with FT. Dyslipidemia, procedure duration and graft type are independent predictors of FT larger than the median, whereas only the procedure duration is a predictor for FT larger than the 75th percentile value. The identified factors regarding radiation protection issues should be considered when contemplating abdominal aortic aneurysm repair, however, without compromising the procedure’s efficacy. Further work is necessary to identify more potential anatomical, clinical and technical factors affecting procedures’ complexity and FT and patient radiation dose during EVAR interventions.
Annexin A1 induces oxaliplatin resistance of gastric cancer through autophagy by targeting PI3K/AKT/mTOR
Authors: Ren Jun , Hu Zhiqing , Niu Gengming , Xia Jie , Wang Xing , Hong Runqi , Gu Jiawei , Wang Daorong , Ke Chongwei 
Published: February 2023

AbstractResistance to oxaliplatin (OXA) is a major cause of recurrence in gastric cancer (GC) patients. Autophagy is an important factor ensuring the survival of cancer cells under chemotherapeutic stress. We aimed to investigate the role of OXA‐related genes in autophagy and chemoresistance of gastric cancer cells. We established OXA‐resistant gastric cancer cells and used RNA‐seq to profile gene expression within OXA‐resistant GC and corresponding parental cells. Immunohistochemistry and RT‐qPCR was performed to detect gene expression in tissues of two cohorts of GC patients who received OXA‐based chemotherapy. The chemoresistant effects of the gene were assessed by cell viability, apoptosis, and autophagy assays. The effects of the gene on autophagy were assessed with mRFP‐GFP‐LC3 and Western blotting (WB). Gene set enrichment analysis (GSEA) and WB were performed to detect the activity of PI3K/AKT/mTOR signaling under the regulation of the gene. The OXA‐resistant property of GC cells is related to their enhanced autophagic activity. Based on RNA‐seq profiling, ANXA1 was selected as a candidate, as it was upregulated significantly in OXA‐resistant cells. Furthermore, we found that higher ANXA1 expression before chemotherapy was associated with subsequent development of resistance to oxaliplatin, and overexpression of ANXA1 promoted the resistance of gastric cancer cells to oxaliplatin. So, it may serve as a key regulator in GC chemo‐resistance knockdown of ANXA1, via inhibiting autophagy, enhancing the sensitivity of OXA‐resistant GC cells to OXA in vitro and in vivo. Mechanically, we identified that PI3K/AKT/mTOR signaling pathway was activated in the ANXA1 stable knockdown AGS/OXA cells, which leads to the suppression of autophagy. ANXA1 functions as a chemoresistant gene in GC cells by targeting the PI3K/AKT/mTOR signaling pathway and might be a prognostic predictor for GC patients who receive OXA‐based chemotherapy.
Transcriptome‐wide high‐throughput m6A sequencing of differential m6A methylation patterns in the decidual tissues from RSA patients
Authors: Luo Yong , Chen Jin , Cui Ying , Fang Fang , Zhang Ziyu , Hu Lili , Chen Xiaoyong , Li Zengming , Li Liping , Chen Lina 
Published: February 2023

AbstractRecurrent spontaneous abortion (RSA) is characterized by two or more consecutive pregnancy losses in the first trimester of pregnancy, experienced by 5% of women during their reproductive age. As a complex pathological process, the etiology of RSA remains poorly understood. Recent studies have established that gene expression changes dramatically in human endometrial stromal cells (ESCs) during decidualization. N6‐methyladenosine (m6A) modification is the most prevalent epigenetic modification of mRNA in eukaryotic cells and it is closely related to the occurrence and development of many pathophysiological phenomena. In this study, we first confirmed that high levels of m6A mRNA methylation in decidual tissues are associated with RSA. Then, we used m6A‐modified RNA immunoprecipitation sequence (m6A‐seq) and RNA sequence (RNA‐seq) to identify the differentially expressed m6A methylation in decidual tissues from RSA patients and identified the key genes involved in abnormal decidualization by bioinformatics analysis. Using m6A‐seq, we identified a total of 2169 genes with differentially expressed m6A methylation, of which 735 m6A hypermethylated genes and 1434 m6A hypomethylated genes were identified. Further joint analysis of m6A‐seq and RNA‐seq revealed that 133 genes were m6A modified with mRNA expression. GO and KEGG analyses indicated that these unique genes were mainly enriched in environmental information processing pathways, including the cytokine–cytokine receptor interaction and PI3K‐Akt signaling pathway. In summary, this study uncovered the transcriptome‐wide m6A modification pattern in decidual tissue of RSA, which provides a theoretical basis for further research into m6A modification and new therapeutic strategies for RSA.
Heterogeneity of macrophages in atherosclerosis revealed by single‐cell RNA sequencing
Authors: Yu Liwen , Zhang Yujie , Liu Changhao , Wu Xiao , Wang Shasha , Sui Wenhai , Zhang Yun , Zhang Cheng , Zhang Meng 
Published: February 2023

AbstractTechnology at the single‐cell level has advanced dramatically in characterizing molecular heterogeneity. These technologies have enabled cell subtype diversity to be seen in all tissues, including atherosclerotic plaques. Critical in atherosclerosis pathogenesis and progression are macrophages. Previous studies have only determined macrophage phenotypes within the plaque, mainly by bulk analysis. However, recent progress in single‐cell technologies now enables the comprehensive mapping of macrophage subsets and phenotypes present in plaques. In this review, we have updated and discussed the definition and classification of macrophage subsets in mice and humans using single‐cell RNA sequencing. We summarized the different classification methods and perspectives: traditional classification with an updated scoring system, inflammatory macrophages, foamy macrophages, and atherosclerotic‐resident macrophages. In addition, some special types of macrophages were identified by specific markers, including IFN‐inducible and cavity macrophages. Furthermore, we discussed macrophage subset‐specific markers and their functions. In the future, these novel insights into the characteristics and phenotypes of these macrophage subsets within atherosclerotic plaques can provide additional therapeutic targets for cardiovascular diseases.
Acute hypoxia attenuates resistance exercise‐induced ribosome signaling but does not impact satellite cell pool expansion in human skeletal muscle
Authors: Horwath Oscar , Nordström Fabian , von Walden Ferdinand , Apró William , Moberg Marcus 
Published: February 2023

AbstractCumulative evidence supports the hypothesis that hypoxia acts as a regulator of muscle mass. However, the underlying molecular mechanisms remain incompletely understood, particularly in human muscle. Here we examined the effect of hypoxia on signaling pathways related to ribosome biogenesis and myogenic activity following an acute bout of resistance exercise. We also investigated whether hypoxia influenced the satellite cell response to resistance exercise. Employing a randomized, crossover design, eight men performed resistance exercise in normoxia (FiO2 21%) or normobaric hypoxia (FiO2 12%). Muscle biopsies were collected in a time‐course manner (before, 0, 90, 180 min and 24 h after exercise) and were analyzed with respect to cell signaling, gene expression and satellite cell content using immunoblotting, RT‐qPCR and immunofluorescence, respectively. In normoxia, resistance exercise increased the phosphorylation of RPS6, TIF‐1A and UBF above resting levels. Hypoxia reduced the phosphorylation of these targets by ~37%, ~43% and ~ 67% throughout the recovery period, respectively (p < .05 vs. normoxia). Resistance exercise also increased 45 S pre‐rRNA expression and mRNA expression of c‐Myc, Pol I and TAF‐1A above resting levels, but no differences were observed between conditions. Similarly, resistance exercise increased mRNA expression of myogenic regulatory factors throughout the recovery period and Pax7+ cells were elevated 24 h following exercise in mixed and type II muscle fibers, with no differences observed between normoxia and hypoxia. In conclusion, acute hypoxia attenuates ribosome signaling, but does not impact satellite cell pool expansion and myogenic gene expression following a bout of resistance exercise in human skeletal muscle.
Psychometric evaluation of the German Day-to-Day Impact of Vaginal Aging questionnaire using data from two intervention studies
Authors: Gabes Michaela , Donhauser Theresa , Harder Anastasia , Masur Clarissa , Apfelbacher Christian J. 
Published: February 2023

Abstract

Objective
We aimed to further validate the German version of the Day-to-Day Impact of Vaginal Aging (DIVA) questionnaire.

Methods
Data were collected in the context of two intervention studies. Forty-two women participated in clinical trial VMP-03/2018 (NCT04222647) and 79 women in clinical trial VFCrC-01/2021 (NCT05211505). Internal consistency was calculated using Cronbach α. Correlations with other outcome measures such as a subjective assessment of symptoms and dyspareunia, the Vaginal Health Index, and the Vaginal Maturation Index were calculated regarding construct validity. A priori hypotheses were formulated for construct validity. Responsiveness was assessed after 43 (±3) and after 38 (±1) days in the two clinical trials.

Results
Strong internal consistency in all of the DIVA domains was found (α ≥ 0.80). Regarding construct validity (at baseline and over time), many hypotheses were confirmed. Furthermore, all of the DIVA domains were able to detect changes over time (P ≤ 0.006). Moderate to strong effect sizes were found (≥0.460). The data supported the responsiveness of the DIVA.

Conclusions
Our findings from two independent intervention studies support internal consistency, construct validity, and responsiveness of the German version of the DIVA (domains).
Treating where it hurts—a randomized comparative trial of vestibule estradiol for postmenopausal dyspareunia
Authors: Goetsch Martha F. , Garg Bharti , Lillemon Jen , Clark Amanda L. 
Published: February 2023

Abstract

Objective
To compare efficacies of two strengths of estradiol cream applied to the vulvar vestibule and use of silicone lubricant to reduce intercourse pain scores in postmenopausal women with moderate/severe dyspareunia.

Methods
This pilot randomized comparative trial assigned 50 women to nightly applications of estradiol cream, 50 or 100 μg, for 12 weeks. We asked women to have lubricated penetration twice weekly, with intercourse or performing a tampon test. Pain, recorded in dairies, was rated using the 0-10 Numerical Rating Scale. We assessed biopsychosocial outcomes, urinary symptoms, and measured serum estradiol levels and endometrial stripe thicknesses. We performed physical examinations to determine tenderness levels of the vestibule, vagina, pelvic floor muscles, bladder, uterus, and adnexa. Comparisons were made using two-sample t test, Wilcoxon rank-sum test, or χ
2/Fisher's exact test.

Results
Forty-seven women (94%), with a mean age of 59.7 years, completed the trial. The baseline median intercourse pain score was 8/10 (interquartile range, 6, 8). After 12 weeks, we measured no statistically significant difference between groups in the primary outcome, intercourse pain score, or any secondary outcome measure. For both groups together, the median intercourse pain score diminished by 50% after 4 weeks and 75% after 12 weeks (P < 0.001). The most tender anatomic area, the vulvar vestibule, improved by 82% to 100% (P < 0.001) with therapy. We did not measure a statistically significant difference in serum estradiol levels or endometrial stripe thickness between groups.

Conclusion
Estradiol cream applied to the vulvar vestibule, paired with precoital silicone lubricant, is a promising alternative to vaginal therapy for dyspareunia.