bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preclinical evaluation of a tool for insertion force measurements in cochlear implant surgery
Authors: Böttcher-Rebmann Georg , Schell Viktor , Zuniga M. Geraldine , Salcher Rolf , Lenarz Thomas , Rau Thomas S. 
Published: June 2023

Abstract
Purpose
Trauma that may be inflicted to the inner ear (cochlea) during the insertion of an electrode array (EA) in cochlear implant (CI) surgery can significantly decrease the hearing outcome of patients with residual hearing. Interaction forces between the EA and the cochlea are a promising indicator for the likelihood of intracochlear trauma. However, insertion forces have only been measured in laboratory setups. We recently developed a tool to measure the insertion force during CI surgery. Here, we present the first ex vivo evaluation of our tool with a focus on usability in the standard surgical workflow.

Methods
Two CI surgeons inserted commercially available EAs into three temporal bone specimens. The insertion force and the orientation of the tool were recorded together with camera footage. The surgeons answered a questionnaire after each insertion to evaluate the surgical workflow with respect to CI surgery.

Results
The EA insertion using our tool was rated successful in all 18 trials. The surgical workflow was evaluated to be equivalent to standard CI surgery. Minor handling challenges can be overcome through surgeon training. The peak insertion forces were 62.4 mN ± 26.7 mN on average. Peak forces significantly correlated to the final electrode insertion depth, supporting the assumption that the measured forces mainly correspond to intracochlear events and not extracochlear friction. Gravity-induced forces of up to 28.8 mN were removed from the signal, illustrating the importance of the compensation of such forces in manual surgery.

Conclusion
The results show that the tool is ready for intraoperative use. In vivo insertion force data will improve the interpretability of experimental results in laboratory settings. The implementation of live insertion force feedback to surgeons could further improve residual hearing preservation.
Efficacy and safety of EGFR inhibitor gefitinib in recurrent or metastatic cervical cancer: a preliminary report
Authors: Krishna Abhishek , Sathya M. , Mukesh S. , Athiyamaan M. S. , Banerjee Sourjya , Sunny Johan , Srinivas Challapalli , Lobo Dilson , Makkapatti Bharat Sai , Jawahar Vaishak 
Published: June 2023

AbstractThere has been growing interest in the use of epidermal growth factor receptor inhibitors in various cancers. The study was conducted to evaluate the efficacy and safety of gefitinib as a monotherapy in patients with recurrent or metastatic cervical cancer. Patients with cervical carcinoma who experienced locoregional recurrence or distant metastases either at presentation or after definitive combined chemoradiotherapy or postoperative radiotherapy were enrolled. Gefitinib was administered orally at a dose of 250 mg/d to eligible patients. Treatment with Gefitinib was continued until disease progression, intolerable adverse effects were developed, or consent was withdrawn. Clinical and radiological investigations were used to verify the disease response. Toxicity was graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0. The study enrolled 32 patients who met the eligibility criteria. Thirty patients were available for the analysis. The majority of the patients included in the analysis had FIGO stage IIIB disease at their initial presentation. The median follow-up time was 6 months (3–15 months). Two patients (7%) had a complete clinical response, 7 patients (23%) had a partial response, 5 patients (17%) showed a stable disease and 16 patients had progressive disease (53%). The disease control rate was 47%. The median PFS was noted to be 4.5 months and the 1-year PFS was 20%. None of the individuals experienced toxicity of grade 3 or higher. All toxicities were managed conservatively. The study suggests that gefitinib may be a promising therapeutic option for patients with advanced cervical cancer who have limited treatment alternatives.
Why Social Robots Need Self-Preservation to Be Objects of Moral Consideration
Authors: Hassan Mohamed 
Published: June 2023

Abstract
While there is a wide agreement today among researchers that robots lack the capacity to be conscious or sentient, two possible dangers are important to address today. Firstly, one could claim that a robot is sentient in the near future or even today in some way that we are not able to understand or verify. Secondly, if we decide to err on the side of caution and grant them legal protection anyway, we could be infringing on personal and intellectual freedom by restricting particular uses of robots or the research and development of said robots. This brings the question that is central to this paper: where can we draw the line? Put in another way, how can we know if SRs are objects of moral consideration (OMCs: such as dogs, bees, or trees) or an object of human desire (OHDs: such as toasters or toys)? This paper presents the condition of self-preservation as a necessary and sufficient condition to draw the line between OMCs and OHDs.
Comparison Study of ANFIS, ANN, and RSM and Mechanistic Modeling for Chromium(VI) Removal Using Modified Cellulose Nanocrystals–Sodium Alginate (CNC–Alg)
Authors: banza Musamba , Seodigeng Tumisang , Rutto Hilary 
Published: June 2023

AbstractThe adsorption process was investigated using the ANFIS, ANN, and RSM models. The adaptive neuro-fuzzy inference system (ANFIS), artificial neural network (ANN), and response surface methodology (RSM) were used to develop an approach for assessing the Cr(VI) adsorption from wastewater using cellulose nanocrystals and sodium alginate. The adsorbent was characterized using Fourier transform infrared spectroscopy and thermogravimetric analysis. Initial pH of 6, contact time of 100 min, initial Cr(VI) concentration of 175 mg/L, sorbent dose of 6 mg, and adsorption capacity of 350.23 mg/g were the optimal condition. The Cr(VI) adsorption mechanism was described via four mechanistic models (film diffusion, Weber and Morris, Bangham, and Dumwald-Wagner models), with correlation values of 0.997, 0.990, and 0.989 for ANFIS, ANN, and RSM, respectively, and predicted the adsorption of the Cr(VI) with incredible accuracy. Statistical error tasks were additionally applied to relate the adequacy of the models. Using the central composite design (CCD), the significance of operating factors such as time, adsorbent dose, pH, and initial Cr(VI) concentration was investigated. The same concept was used to create a training set for ANN where the Levenberg–Marquardt, variable learning rate, and Polak Ribiere conjugate algorithms were used. Further statistical indices supported ANFIS as the best prediction model for adsorption compared to ANN and RSM. The efficient algorithm was used to optimize the process, which resulted in a 350 mg/g adsorption capacity. Film diffusion was identified as the rate-limiting process via mechanistic modeling.
Supplementary UV-A and UV-B radiation differentially regulate morphology in Ocimum basilicum
Authors: Qian Minjie , Kalbina Irina , Rosenqvist Eva , Jansen Marcel A. K. , Strid Åke 
Published: June 2023

AbstractUV-A- or UV-B-enriched growth light was given to basil plants at non-stress-inducing intensities. UV-A-enriched growth light gave rise to a sharp rise in the expression of PAL and CHS genes in leaves, an effect that rapidly declined after 1–2 days of exposure. On the other hand, leaves of plants grown in UV-B-enriched light had a more stable and long-lasting increase in the expression of these genes and also showed a stronger increase in leaf epidermal flavonol content. UV supplementation of growth light also led to shorter more compact plants with a stronger UV effect the younger the tissue. The effect was more prominent in plants grown under UV-B-enriched light than in those grown under UV-A. Parameters particularly affected were internode lengths, petiole lengths and stem stiffness. In fact, the bending angle of the 2nd internode was found to increase as much as 67% and 162% for plants grown in the UV-A- and UV-B-enriched treatments, respectively. The decreased stem stiffness was probably caused by both an observed smaller internode diameter and a lower specific stem weight, as well as a possible decline in lignin biosynthesis due to competition for precursors by the increased flavonoid biosynthesis. Overall, at the intensities used, UV-B wavelengths are stronger regulators of morphology, gene expression and flavonoid biosynthesis than UV-A wavelengths.
Graphical abstract
Challenges and strategies for recruitment of minorities to clinical research and trials
Authors: Fisher-Hoch Susan P. , Below Jennifer E. , North Kari E. , McCormick Joseph B. 
Published: June 2023

Abstract
Minority populations are largely absent from clinical research trials. The neglect of these populations has become increasingly apparent, with escalating cancer burdens and chronic disease. The challenges to recruitment of minorities in the United States are multiple including trust or lack thereof. Keys to successful recruitment are responding to community issues, its history, beliefs, and its social and economic pressures. The strategy we have used in many low-income, sometimes remote, communities is to recruit staff from the same community and train them in the required basic research methods. They are the first line of communication. After our arrival in the Texas Rio Grande Valley in 2001, we applied these principles learned over years of global research, to studies of chronic diseases. Beginning in 2004, we recruited and trained a team of local women who enrolled in a cohort of over five thousand Mexican Americans from randomly selected households. This cohort is being followed, and the team has remained, acquiring not only advanced skills (ultrasound, FibroScan, retinal photos, measures of cognition, etc.) but capacity to derive key health information. Currently, we are participating in multiple funded studies, including an NIH clinical trial, liver disease, obesity, and diabetes using multiomics aimed at developing precision medicine approaches to chronic disease prevention and treatment.
Automorphisms of -free and other Toeplitz shifts
Authors: DYMEK AURELIA , KASJAN STANISŁAW , KELLER GERHARD 
Published: June 2023

AbstractWe present sufficient conditions for the triviality of the automorphism group of regular Toeplitz subshifts and give a broad class of examples from the class of
${\mathcal B}$
-free subshifts satisfying them, extending the work of Dymek [Automorphisms of Toeplitz
${\mathcal B}$
-free systems. Bull. Pol. Acad. Sci. Math.65(2) (2017), 139–152]. Additionally, we provide an example of a
${\mathcal B}$
-free Toeplitz subshift whose automorphism group has elements of arbitrarily large finite order, answering Question 11 of S. Ferenczi et al [Sarnak’s conjecture: what’s new. Ergodic Theory and Dynamical Systems in their Interactions with Arithmetics and Combinatorics (Lecture Notes in Mathematics, 2213). Eds. S. Ferenczi, J. Kułaga-Przymus and M. Lemańczyk. Springer, Cham, 2018, pp. 163–235].
On The Host in the Modern World
Authors: Alonso Antonio 
Published: June 2023

ABSTRACTThis article traces the contemporary history of the eucharistic host, arguing that the materiality of modern Catholicism offers a distinct set of insights into the ways in which the Catholic Church has negotiated, resisted, and accommodated the modern world. Drawing on archival work, writings from a range of early twentieth-century Catholic journals, and advertising campaigns for altar bread, I show how shifting theological convictions about the Eucharist transformed both the form of altar bread as well as how and by whom it was made. Long before the Second Vatican Council, efforts to increase lay reception of communion as a strategy to mobilize Catholics against modernity had the effect of increasing demand for the bread on which it depended. After the Council, new convictions about the need for more intelligible liturgical symbols were accompanied by demands for a new kind of bread. Taken together, I argue that these factors unwittingly contributed to the creation of a new economy of host production. While the relationship between the church and the modern world remains one of the most enduring tensions in modern Catholicism in the wake of Vatican II, I show how both before and after the Council, the Catholic Church was deeply enmeshed in and dependent upon that world to achieve its ends.
Associations of alcohol and cannabis use with change in posttraumatic stress disorder and depression symptoms over time in recently trauma-exposed individuals
Authors: Hinojosa Cecilia A. , Liew Amanda , An Xinming , Stevens Jennifer S. , Basu Archana , van Rooij Sanne J. H. , House Stacey L. , Beaudoin Francesca L. , Zeng Donglin , Neylan Thomas C. , Clifford Gari D. , Jovanovic Tanja , Linnstaedt Sarah D. , Germine Laura T. , Rauch Scott L. , Haran John P. , Storrow Alan B. , Lewandowski Christopher , Musey Paul I. , Hendry Phyllis L. , Sheikh Sophia , Jones Christopher W. , Punches Brittany E. , Kurz Michael C. , Swor Robert A. , Hudak Lauren A. , Pascual Jose L. , Seamon Mark J. , Datner Elizabeth M. , Chang Anna M. , Pearson Claire , Peak David A. , Merchant Roland C. , Domeier Robert M. , Rathlev Niels K. , Sergot Paulina , Sanchez Leon D. , Bruce Steven E. , Miller Mark W. , Pietrzak Robert H. , Joormann Jutta , Pizzagalli Diego A. , Sheridan John F. , Harte Steven E. , Elliott James M. , Kessler Ronald C. , Koenen Karestan C. , McLean Samuel A. , Ressler Kerry J. , Fani Negar 
Published: June 2023

AbstractBackgroundSeveral hypotheses may explain the association between substance use, posttraumatic stress disorder (PTSD), and depression. However, few studies have utilized a large multisite dataset to understand this complex relationship. Our study assessed the relationship between alcohol and cannabis use trajectories and PTSD and depression symptoms across 3 months in recently trauma-exposed civilians.MethodsIn total, 1618 (1037 female) participants provided self-report data on past 30-day alcohol and cannabis use and PTSD and depression symptoms during their emergency department (baseline) visit. We reassessed participant's substance use and clinical symptoms 2, 8, and 12 weeks posttrauma. Latent class mixture modeling determined alcohol and cannabis use trajectories in the sample. Changes in PTSD and depression symptoms were assessed across alcohol and cannabis use trajectories via a mixed-model repeated-measures analysis of variance.ResultsThree trajectory classes (low, high, increasing use) provided the best model fit for alcohol and cannabis use. The low alcohol use class exhibited lower PTSD symptoms at baseline than the high use class; the low cannabis use class exhibited lower PTSD and depression symptoms at baseline than the high and increasing use classes; these symptoms greatly increased at week 8 and declined at week 12. Participants who already use alcohol and cannabis exhibited greater PTSD and depression symptoms at baseline that increased at week 8 with a decrease in symptoms at week 12.ConclusionsOur findings suggest that alcohol and cannabis use trajectories are associated with the intensity of posttrauma psychopathology. These findings could potentially inform the timing of therapeutic strategies.
In memoriam: Professor Abraham Rudolph (1924– April 9, 2023) - a tribute
Authors: Silverman Norman H. , Teitel David F. 
Published: June 2023

AbstractDr Abraham Rudolph, one of the foremost leaders in Pediatric Cardiology, passed away on April 9, 2023, aged 99. His entire career was marked by imagination, creativity, and a devotion to the care of children with heart disease. He will be sorely missed by the many who knew him personally and the countless physicians whose understanding of their specialty was enhanced by his discoveries and teachings.
Situs inversus with dextrocardia and transposition of great arteries
Authors: Emral Hicran Gül , Kamali Hacer , Guzeltas Alper , Haydin Sertac 
Published: June 2023

AbstractTransposition of the great arteries with left ventricle outflow tract obstruction in combination with situs inversus totalis and dextrocardia is a very rare anomaly and carries high morbidity and mortality. Only few cases have been reported with this anomaly. We describe a 21-day of infant girl with transposition of the great arteries and mirror image dextrocardia and pulmonary stenosis who underwent successful neonatal arterial switch operation and left ventricle outflow tract obstruction resection following PDA stent implantation
THE DIAGONAL CYCLE EULER SYSTEM FOR
Authors: Alonso Raúl , Castella Francesc , Rivero Óscar 
Published: June 2023

AbstractWe construct an anticyclotomic Euler system for the Rankin–Selberg convolutions of two modular forms, usingp-adic families of generalised Gross–Kudla–Schoen diagonal cycles. As applications of this construction, we prove new results on the Bloch–Kato conjecture in analytic ranks zero and one, and a divisibility towards an Iwasawa main conjecture.
Improved Vegetation Photosynthetic Phenology Monitoring in the Northern Ecosystems Using Total Canopy Solar‐Induced Chlorophyll Fluorescence Derived From TROPOMI
Authors: Liu Haoran , Liu Junzhi , Yin Yueqiang , Walther Sophia , Ma Xuanlong , Zhang Zhaoying , Chen Yuhan 
Published: June 2023

AbstractSolar‐Induced chlorophyll Fluorescence (SIF) from the TROPOspheric Monitoring Instrument (TROPOMI) with substantially improved spatiotemporal resolutions provides a new potential to improve satellite‐based phenology monitoring. The performance of TROPOMI SIF for tracking vegetation photosynthetic phenology, and how it compares to conventional vegetation indices (VIs)‐based approaches, however, have not been adequately assessed. Total canopy SIF, as a better proxy of Gross Primary Productivity (GPP) than original directional SIF, is a new SIF to estimate phenology while its performance has not been investigated. This study assesses the capability of TROPOMI SIF before and after canopy correction for phenology monitoring and improves our understanding of these questions. Benchmarked by tower‐based GPP, TROPOMI SIF generally performed better than VIs, especially for capturing the End Of Season (EOS) of vegetation photosynthetic activity at deciduous broadleaf forest (DBF), evergreen forest (ENF), and croplands (CRO) sites, but not for Start Of Season (SOS). This suggested that the advantage of SIF over VIs depended on phenological metrics. The total canopy SIF emission obtained through canopy correction generally performed better than the original SIF retrievals, especially in estimating the EOS of forest sites (DBF, MF, ENF), but soil correction did not further improve the accuracy of phenological monitoring. When comparing SIF‐ and VI‐based phenological metrics over northern terrestrial ecosystems, SIF showed earlier senescence date widely, while the differences in onset date were region dependent. These results indicate the necessity of canopy correction to convert directional SIF to canopy total SIF when using satellite SIF products to estimate phenological metrics.
Insights of Active Extension Within a Collisional Orogen From GNSS (Central Betic Cordillera, S Spain)
Authors: Martin‐Rojas I. , Alfaro P. , Galindo‐Zaldivar J. , Borque‐Arancón M. J. , García‐Tortosa F. J. , Sanz de Galdeano C. , Avilés M. , Sánchez‐Alzola A. , González‐Castillo L. , Ruano P. , Medina‐Cascales I. , Tendero‐Salmerón V. , Madarieta‐Txurruka A. , Pedrosa‐González M. T. , Gil‐Cruz A. J. 
Published: June 2023

AbstractThe coexistence of shortening and extensional tectonic regimes is a common feature in orogenic belts. The westernmost end of the Western Mediterranean is an area undergoing shortening related to the 5 mm/yr NNW‒SSE convergence of the Nubia and Eurasia Plates. In this region, the Central Betic Cordillera shows a regional ENE‒WSW extension. Here, we present GNSS‐derived geodetic data along a 170 km‐long transect orthogonal to the main active normal faults of the Central Betic Cordillera. Our data indicate that the total extension rate along the Central Betic Cordillera is 2.0 ± 0.3 mm/yr. Extension is accommodated in the eastern (0.8 ± 0.3 mm/yr in the Guadix‐Baza Basin) and western (1.3 ± 0.3 mm/yr in the Granada Basin) parts of the Central Betic Cordillera, while no extension is recorded in the central part of the study area. Moreover, our data permit us to quantify, for the first time, short‐term fault slip rates of the Granada Fault System, which is one of the main seismogenic sources of the Iberian Peninsula. We deduce a fault slip rate of ∼1.3 ± 0.3 mm/yr for the whole Granada Basin, with 0.9 ± 0.3 mm/yr being accommodated in the Granada Fault System and 0.4 ± 0.3 mm/yr being accommodated in the southwestern sector of the Granada Basin, where no active faults have been previously described at the surface. The heterogeneous extension in the Central Betic Cordillera could be accommodated by shallow high‐angle normal faults that merge with a detachment at depth. Part of the active extension could be derived from gravitational instability because of underlying over‐thickened crust.
Precision of Spacecraft Doppler Tracking at Low Signal‐To‐Noise Ratios
Authors: Buccino D. R. , Oudrhiri K. , Parisi M. , Park R. S. , Mazarico E. , Tortora P. , Withers P. , Genova A. , Zannoni M. 
Published: June 2023

AbstractThe signal‐to‐noise ratio received at Earth is typically larger than 10 dB‐Hz for radio tracking of a spacecraft in deep space, allowing a phase‐locked loop to execute reliable carrier tracking. Recently, missions have been proposed to utilize low‐gain antennas for Doppler tracking where the signal‐to‐noise ratio may be at the single‐digit (dB‐Hz) level. In this work, we discuss spacecraft Doppler tracking at these low signal‐to‐noise ratios through an analysis of thermal noise on the radio link, results from ground testing with the Deep Space Network, and demonstrations with an active spacecraft. We show that by utilizing an open‐loop receiver to capture the carrier signal and by applying post‐processing techniques, radio data with the signal‐to‐noise ratio as low as 4 dB‐Hz can be used to derive Doppler data with precision sufficient for tracking a spacecraft in deep space.