bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adherence to CONSORT for Abstracts in Orthodontic Randomized Controlled Trials Published in Leading Journals (2018-2022)
Authors: Alharbi Fahad , Asiri Saeed 
Published: January 2025

Objective
To investigate the adherence to CONSORT guidelines for reporting abstracts of orthodontic RCTs published in leading journals.

Methods
This retrospective observational study examined abstracts of RCTs published in four orthodontic journals (2018-2022): American Journal of Orthodontics and Dentofacial Orthopedics (AJODO), Journal of Orthodontics (JO), European Journal of Orthodontics (EJO), and Angle Orthodontist Journal (AO). The abstracts were identified using keywords and then assessed for completeness based on the CONSORT for Abstracts checklist. Inter-examiner reliability was assessed to ensure consistency in scoring.

Results
The mean CONSORT score for adherence to reporting guidelines was 65.6%, indicating that abstracts often lacked essential information. There was variation between journals, with the American Journal of Orthodontics and Dentofacial Orthopedics achieving the highest average score. The completeness of reporting varied across different CONSORT items. Essential elements like the study participants, interventions, objectives, outcomes, and conclusions were consistently reported. However, crucial methodological details such as randomization procedures, blinding techniques, recruitment status, adverse events, trial registration, and funding sources were frequently missing from the abstracts.

Conclusion
This study highlights the need for improved reporting quality in abstracts of orthodontic RCTs. Key areas requiring more attention include providing details on trial design, participant characteristics, and funding sources. Standardizing word count limitations across journals could potentially give authors more space to ensure comprehensive reporting within abstracts. Furthermore, by implementing these changes, researchers can ensure that abstracts provide readers with the essential information needed to make informed decisions about orthodontic treatments.
A Comprehensive Pharmacological Review of Natural Products Active Ingredients in Ulcerative Colitis
Authors: Hong Ran , Zhang Zengni , Sun Xiaoli , Chen Yajuan , Wei HuiLin , Chen Qiulin , Zhou Lisha , Zhou Xia , Chen Wenwen , Wan Jun 
Published: January 2025

Abstract:
Ulcerative colitis (UC) is a nonspecific, prolonged, and recurrent autoimmune disease
characterized by diarrhea, mucopurulent stools, and abdominal pain. Modern medicine believes that
the disease is related to infectious, genetic, psychiatric, allergic and especially autoimmune factors,
but the exact cause is unknown. Given that the disease is recurrent, aggravating and persistent, and
has a certain cancer rate, it is increasingly urgent to find effective treatments. It has been proved that
UC is related to the abnormal regulation of signaling pathways in the body, dysregulation of intestinal
ecology, and intestinal immune disorders, and natural products active ingredients for the treatment
of UC have the advantage of long-term efficacy and less toxic side effects compared to existing
drugs. This paper reviews the pharmacological mechanisms associated with UC to gain insight into
the therapeutic mechanisms of natural products active ingredients for UC and to better understand
the advantages and potential of natural products active ingredients in the treatment of UC. This will
provide guidance for the development of new therapeutic strategies and drugs, and offer new hope
for improving the quality of life of patients with UC.
Microbial Fuel Cell an Alternative for Sustainable Energy Production: Substrate, Challenges and Application
Authors: Saraf Renuka , Goyal Ayushi , Jain Divya , Dutt Kakoli 
Published: January 2025

Abstract:
The concept of bioelectricity has been known for over half a century. Its modern
application in the form of a battery or fuel cell utilizing microbes and degradable organic molecules
opens up a new domain of energy production in the form of Microbial fuel cells (MFC). This
technology not only supports the sustainable development goals by being green and but also
facilitates the utilization of a wide range of biosubstrates, leading to coupled applications like
wastewater treatment, desalination, etc. The development of viable models of MFC and their
possible scale-up for use is a major focus of the researchers as the global energy crisis increases and
the search for alternatives widens. The construction, configuration, electrodes, electrolytes, and
microorganisms used play a very relevant role in determining the performance, longevity, and utility
of MFC. Furthermore, exploration of the underlying biochemical mechanisms and influence of MFC
components on it leading to variabilities in coulombic efficiencies and power output are key areas
underlying its development. This review attempts to present a cohesive summary of important
achievements in the development of MFC research attempted globally.
Comprehensive Review on Tinea Infection Therapies: Allopathic and Herbal Approaches for Dermatophytosis
Authors: Rathi Mehak , Kamaboj Sweta , Guarve Kumar , Kamboj Rohit , Dass Rameshwar 
Published: January 2025

Background:
Tinea infections are superficial fungal infections caused by three
species of fungi (i.e. Epidermophyton, Microsporum, and Trichophyton) collectively
termed dermatophytes. Dermatophytes are fungi that cause skin, nail bed, and hair infections.
These infections are classified based on infection site, including tinea pedis (foot),
tinea corporis (body), tinea capitis (head), and tinea cruris (groin). Dermatophytes can
spread by direct contact with other people (anthropophilic organisms), animals (zoophilic
organisms), and soil (geophilic organisms), as well as indirectly from fomities.

Objective:
This review aims to summarize the allopathic drugs along with their mechanism
of action and herbal drugs including their parts of the plant used for the treatment of tinea
infections.

Methods:
The literature review was performed using the following databases: PubMed
(https://pubmed.ncbi.nlm.nih.gov/), and Google Scholar (https://scholar.google.com/), to
identify the various drugs involved in the treatment of dermatophytosis along with their
mechanisms.

Results:
The following keywords were applied in the search strategy: “Tinea”, “Dermatophytosis”,
“Ringworm infection”, “Pathogenesis of tinea”, “Tinea pedis”, and “Tinea capitis”. This
article also reviews several formulations that are available in the market for treating ringworm
infection.

Conclusion:
The current review provides information about the classification of dermatophytosis
based on infection site and environmental habitat, pathogenesis, immunopathogenesis
of dermatophytes, and herbals and allopathic drugs used for their treatment.
Exploring Older Adults’ Needs for a Healthy Life and eHealth: Qualitative Interview Study
Authors: Valkonen Paula , Kujala Sari , Savolainen Kaisa , Helminen Riina-Riitta 
Published: January 2025

Background
Aging brings physical and life changes that could benefit from eHealth services. eHealth holistically combines technology, tasks, individuals, and contexts, and all these intertwined elements should be considered in eHealth development. As users’ needs change with life situations, including aging and retirement, it is important to identify these needs at different life stages to develop eHealth services for well-being and active, healthy lives.

Objective
This study aimed to (1) understand older adults’ everyday lives in terms of well-being and health, (2) investigate older adults’ needs for eHealth services, and (3) create design recommendations based on the findings.

Methods
A total of 20 older adults from 2 age groups (55 to 74 years: n=12, 60%; >75 years: n=8, 40%) participated in this qualitative interview study. The data were collected remotely using a cultural probes package that included diary-based tasks, sentence completion tasks, and 4 background questionnaires; we also performed remote, semistructured interviews. The data were gathered between the fall of 2020 and the spring of 2021 in Finland as a part of the Toward a Socially Inclusive Digital Society: Transforming Service Culture (DigiIN) project (2019 to 2025).

Results
In the daily lives of older adults, home-based activities, such as exercising (72/622, 11.6% of mentions), sleeping (51/622, 8.2% of mentions), and dining and cooking (96/622, 15.4% of mentions), promoted well-being and health. When discussing their needs for eHealth services, participants highlighted a preference for a chat function. However, they frequently mentioned barriers and concerns such as the lack of human contact, inefficiency, and difficulties using eHealth systems. Older adults value flexibility; testing possibilities (eg, trial versions); support for digital services; and relevant, empathetically offered content with eHealth services on short-term and long-term bases in their changing life situations.

Conclusions
Many older adults value healthy routines and time spent at home. The diversity of older adults’ needs should be considered by making it possible for them to manage their health safely and flexibly on different devices and channels. eHealth services should adapt to older adults’ life changes through motivation, personalized content, and appropriate functions. Importantly, older adults should still have the option to not use eHealth services.
Understanding the Psychosocial Impact of Assistive Technologies for People With Visual Impairments: Protocol for a Scoping Review
Authors: Szekely Raul , Holloway Catherine , Bandukda Maryam 
Published: January 2025

Background
There has been a rapid growth in the literature on the design and evaluation of assistive technologies for people with visual impairments; yet, there is a lack of a comprehensive analysis of the existing literature on the classification of immediate-, short-, medium-, and long-term psychosocial impact of assistive technologies on the quality of life of people with visual impairments.

Objective
This protocol outlines the methodology for a scoping review aimed at identifying and synthesizing the existing literature on the psychosocial impact of assistive technologies on the quality of life of people with visual impairments.

Methods
The review will include primary research studies published in English between 2019 and 2024 that focus on the psychosocial outcomes of assistive technologies for people with visual impairments. Eligible studies will involve participants with visual impairments, of all ages and across various settings, examining psychological (eg, emotional well-being and self-esteem) and social outcomes (eg, social participation and support). Searches will be conducted across 7 electronic research databases: CINAHL (EBSCO), PsycINFO (EBSCO), ACM Digital Library, IEEE Xplore, Scopus, Web of Science, and Google Scholar (first 100 records). Studies will undergo screening and selection based on predefined eligibility criteria, with data extraction focusing on publication details, study design, population characteristics, type of assistive technology, and psychosocial impacts. Results will be summarized using descriptive statistics, charts, and narrative synthesis.

Results
The database search, conducted in July 2024, identified 1145 records, which will be screened and analyzed in subsequent stages of the review process. This protocol outlines the planned approach for identifying, categorizing, and synthesizing evidence. The study findings are anticipated to be finalized and submitted for publication in a peer-reviewed journal by February 2025.

Conclusions
This study will synthesize the recent body of work on the psychosocial impact of assistive technologies for people with visual impairments and recommendations for researchers and designers interested in this research area.

Trial Registration
Open Science Framework 10.17605/OSF.IO/SK7N8; https://osf.io/4gc5t

International Registered Report Identifier (IRRID)
DERR1-10.2196/65056
Measuring Digital Health Literacy in Older Adults: Development and Validation Study
Authors: Kim SungMin , Park Choonghee , Park Sunghyeon , Kim Dai-Jin , Bae Ye-Seul , Kang Jae-Heon , Chun Ji-Won 
Published: January 2025

Background
New health care services such as smart health care and digital therapeutics have greatly expanded. To effectively use these services, digital health literacy skills, involving the use of digital devices to explore and understand health information, are important. Older adults, requiring consistent health management highlight the need for enhanced digital health literacy skills. To address this issue, it is imperative to develop methods to assess older adults’ digital health literacy levels.

Objective
This study aimed to develop a tool to measure digital health literacy. To this end, it reviewed existing literature to identify the components of digital health literacy, drafted preliminary items, and developed a scale using a representative sample.

Methods
We conducted a primary survey targeting 600 adults aged 55-75 years and performed an exploratory factor analysis on 74 preliminary items. Items with low factor loadings were removed, and their contents were modified to enhance their validity. Then, we conducted a secondary survey with 400 participants to perform exploratory and confirmatory factor analyses.

Results
A digital health literacy scale consisting of 25 items was developed, comprising 4 subfactors: use of digital devices, understanding health information, use and decision regarding health information, and use intention. The model fit indices indicated excellent structural validity (Tucker-Lewis Index=0.924, comparative fit index=0.916, root-mean-square error of approximation=0.088, standardized root-mean-square residual=0.044). High convergent validity (average variance extracted>0.5) and reliability (composite reliability>0.7) were observed within each factor. Discriminant validity was also confirmed as the square root of the average variance extracted was greater than the correlation coefficients between the factors. This scale demonstrates high reliability and excellent structural validity.

Conclusions
This study is a significant first step toward enhancing digital health literacy among older adults by developing an appropriate tool for measuring digital health literacy. We expect this study to contribute to the future provision of tailored education and treatment based on individual literacy levels.
How do Explanations Justify?
Authors: Bodlović Petar , Lewiński Marcin 
Published: January 2025

Abstract: The paper presents an extended scheme for the inference to the best explanation (IBE). The scheme precisely treats the epistemic modifiers (“hypothetically,” “plausibly,” “presumably”) of the inference, acknowledges its contrastive nature, clarifies the logical support between premises and conclusions (linked, convergent, and serial support), and introduces additional premises essential for inferring justified conclusions (especially those related to causal explanations and more demanding standards of proof). Overall, it advances the existing schemes for IBE in argumentation theory and treats IBE as a par excellence argumentative, rather than explanatory, form of reasoning.

Résumé: L’article présente en détail un schéma pour l’inférence vers la meilleure explication (IME). Le schéma traite précisément les modificateurs épistémiques (« hypothétiquement », « plausiblement », « vraisemblablement ») de l’inférence, reconnaît sa nature qui fait contraste, clarifie l’appui logique entre les prémisses et les conclusions (l’appui lié, convergent et sériel) et introduit des prémisses supplémentaires essentielles pour inférer des conclusions justifiées (en particulier celles liées aux explications causales et aux normes de preuve plus exigeantes). Dans l’ensemble, l’article fait progresser les schémas existants pour l’IME dans la théorie de l’argumentation et traite l’IME comme une forme de raisonnement argumentatif par excellence, plutôt qu’explicatif.
High-resolution whole-genome DNA methylation revealed unique signatures of painful diabetic neuropathy
Authors: Kwiatkowska Katarzyna Malgorzata , Garagnani Paolo , Bonafé Massimiliano , Bacalini Maria G. , Sala Claudia , Castellani Gastone , Gentilini Davide , Calzari Luciano , Ziegler Dan , Gerrits Monique M. , Faber Catharina G. , Malik Rayaz A. , Marchi Margherita , Salvi Erika , Lauria Giuseppe , Pirazzini Chiara 
Published: January 2025

The aim of this work was to describe the DNA methylation signature and to identify genes associated with neuropathic pain in type 2 diabetes mellitus.
We analyzed two independent diabetic neuropathy cohorts: PROPGER consisting of 72 painful and 67 painless patients recruited at the German Diabetes Center in Düsseldorf (DE), and PROPENG comprising 27 painful and 65 painless diabetic neuropathy patients recruited at the University of Manchester (UK). Genome-wide methylation data was generated using Illumina Infinium Methylation EPIC v1.0 BeadChip. We used four different selection criteria to identify promising pain-related genes. Our findings revealed significant differences in methylation patterns between painful and painless diabetic neuropathy and identified a set of individual CpG sites of unique candidate genes associated with the painful phenotype. Several of these genes, including GCH1, MYT1L and MED16, have been previously linked to pain-related phenotypes or diabetes. Through pathway enrichment analysis, we demonstrated that specific epigenetic signatures could contribute to the complex phenotype of diabetic neuropathy and cluster analyses highlighted significant epigenetic dissimilarities between painful and painless phenotypes.
Our results uncovered epigenetic differences between painful and painless diabetic neuropathy patients and identified targeted genes linked to neuropathic pain through DNA methylation mechanisms. This approach holds promise for investigating other chronic pain conditions, such as secondary chronic pain from cancer treatment, thoracic surgery, and various transplant settings.
Glucagon-Like Peptide 1 Receptor Agonists and Sodium–Glucose Cotransporter 2 Inhibitors and the Prevention of Cirrhosis Among Patients With Type 2 Diabetes
Authors: Pradhan Richeek , Yin Hui , Lu Sally , Sebastiani Giada , Yu Oriana , Suissa Samy , Azoulay Laurent 
Published: January 2025

OBJECTIVE
To determine whether glucagon-like peptide 1 receptor agonists (GLP-1RAs) and sodium–glucose cotransporter 2 (SGLT-2) inhibitors, separately, compared with dipeptidyl peptidase 4 (DPP-4) inhibitors are associated with a reduced risk of cirrhosis and other adverse liver outcomes among patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS
With an active comparator, new-user approach, we conducted a cohort study using the U.K. Clinical Practice Research Datalink linked with hospital and national statistics databases. Cox proportional hazards models using propensity score fine stratification weighting were used to calculate hazard ratios (HRs) and 95% CIs for cirrhosis (primary outcome) and decompensated cirrhosis, hepatocellular carcinoma, and liver-related mortality (secondary outcomes).

RESULTS
In the first cohort comparing 25,516 patients starting GLP-1RAs and 186,752 starting DPP-4 inhibitors, GLP-1RAs were not associated with the incidence of cirrhosis (HR 0.90, 95% CI 0.68–1.19) or the secondary outcomes. In a separate cohort comparing 33,161 patients starting SGLT-2 inhibitors and 124,431 starting DPP-4 inhibitors, SGLT-2 inhibitors were associated with a reduced incidence of cirrhosis (HR 0.64, 95% CI 0.46–0.90), as also decompensated cirrhosis (HR 0.74, 95% CI 0.54–1.00), but not with a lower risk of hepatocellular carcinoma or liver-related mortality.

CONCLUSIONS
In patients with type 2 diabetes in the U.K., GLP-1RAs were not associated with a lower risk of cirrhosis compared with DPP-4 inhibitors in patients with type 2 diabetes. However, SGLT-2 inhibitors were associated with a lower risk of cirrhosis compared with DPP-4 inhibitors.
BRICS: Tantangan dan Peluang Dalam Tata Kelola Global
Authors: Muhammad Fawwaz Afif  , Adrian Maulana Firmansyah  , Dudy Heryadi  , Deasy Silvya Sari  
Published: January 2025

BRICS merupakan salah satu kekuatan ekonomi dan politik baru di dunia. Peran mereka dalam tata kelola global semakin penting. Namun, BRICS juga menghadapi berbagai tantangan dan peluang dalam tata kelola global.Tantangan internal yang dihadapi oleh BRICS antara lain: keragaman latar belakang dan kepentingan, ketidakseimbangan kekuatan, dan kurang pengalaman. Tantangan eksternal yang dihadapi oleh BRICS antara lain: oposisi dari negara-negara Barat dan persaingan dari negara-negara lain. BRICS juga memiliki berbagai peluang dalam tata kelola global, yaitu kekuatan ekonomi yang semakin besar, keberagaman latar belakang dan kepentingan, dan kebutuhan akan perubahan. Untuk mengatasi tantangan dan memanfaatkan peluang dalam tata kelola global, BRICS perlu meningkatkan kerja sama dan koordinasi di antara anggotanya, membangun kapasitas dan pengalaman, serta membangun hubungan kerja sama dengan negara-negara lain.
Effect of oral premedication with gabapentin and trazodone combination on the MAC of isoflurane in dogs
Authors: Aiello Jacob , Carson Brittney , Aarnes Turi , Wanstrath Audrey , McLoughlin Mary 
Published: January 2025

Abstract

OBJECTIVE
To determine the effect of the administration of oral gabapentin (20 mg/kg) and trazodone (8 mg/kg) on the MAC of isoflurane in dogs.

METHODS
6 adult dogs (3 castrated males and 3 spayed females), aged 13.3 ± 1.5 months and weighing 36.8 ± 3.4 kg (mean ± SD), were each anesthetized twice, separated by at least 7 days. Dogs were randomly assigned to receive gabapentin (20 mg/kg orally) and trazodone (8 mg/kg orally) followed by maintenance isoflurane or maintenance isoflurane alone. For their second event, dogs received the other treatment. The MAC was determined using an iterative bracketing technique with electric stimulation. Hemodynamic variables and vital parameters were assessed throughout the anesthetic episode. The effect of treatment on outcome variables was analyzed by use of a paired t test (P < .05).

RESULTS
The mean ± SD MAC of isoflurane in dogs was significantly lower with gabapentin and trazodone premedication and isoflurane (0.625 ± 0.18%) compared with isoflurane alone (0.95 ± 0.14%). The mean MAC of isoflurane reduction was 0.33 ± 0.04%. Heart rate was decreased but still within normal limits in premedicated dogs. Other hemodynamic variables did not differ significantly between treatments.

CONCLUSIONS
Oral administration of gabapentin (20 mg/kg) and trazodone (8 mg/kg) 2 hours before anesthesia maintained with isoflurane had a MAC-sparing effect with no significant effect on hemodynamic variables in dogs.

CLINICAL RELEVANCE
Oral premedication with gabapentin and trazodone could be administered before anesthesia to decrease MAC, thus limiting dose-dependent anesthetic risks.