bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of physicochemical, nutritional, functional, and sensory properties of rice bran oil from white (Bg 300) and brown rice (At 362)
Authors: Jans Harshaka M. , Perumpuli P.A. Buddhika N. , Abeysuriya A.P. Hashini I. 
Published: February 2025

Abstract
Rice bran oil (RBO) is one of the healthiest edible oils in the world is locally underutilized. The current study was conducted to examine the physicochemical, nutritional, functional and sensory properties of RBO extracted from two locally grown rice varieties Bg 300 (white rice bran oil: WRBO) and At 362 (brown rice bran oil: BRBO) and to compare those with commercially available coconut oil (CACO). Saponification value in RBOs varied in the range of 175–176 mg KOH/g. BRBO showed a higher peroxide (3.71 ± 0.80 meq O2/kg) and Iodine value (98.38 ± 0.05 g I2/100 g) compared to WRBO. Highest oleic acid percentage (45.34 ± 2.65 %) and smoke point (204.6 ± 8.3 °C) was observed in BRBO. Significantly highest potassium (133.10 ± 1.07 mg/kg) and sodium (76.80 ± 0.10 mg/kg) contents were observed in BRBO and CACO respectively. Further, BRBO showed the highest contents of ɤ-oryzanol (1.49 ± 0.04 %), total flavonoid (1.13 ± 7.66 mg QE/g), total phenolic (1.47 ± 1.46 mg GAE/g) and DPPH radical scavenging capacity (1.04 ± 0.07 mmol Trolox/g). As a whole, BRBO from At362 showed acceptable physicochemical, nutritional and functional properties compared to WRBO and CACO proving it as a promising application in local food industry while utilizing rice bran, a by-product in rice milling.
Intelligent food packaging from Ganyong starch (Canna Edulis Kerr.) modified with nanocellulose from corn husk (Zea mays) and curcumin as bioindicator
Authors: Purwaningsih Henny , Yupa Nor Pana , Kemala Tetty , Kustiariyah Kustiariyah , Widiastuti Diana 
Published: February 2025

Abstract
Consumer demand for food safety and quality is driving innovation in eco-friendly and intelligent food packaging. This intelligent packaging can monitor product quality and reduce the risk of spoilage. One innovation uses natural indicators, such as curcumin, which is sensitive to changes in pH and can detect food spoilage. Research on intelligent packaging with curcumin indicators based on ganyong starch with nanocellulose from corn husk has never been done. Isolation of nanocellulose from corn husk produced a yield of 40.84 %. Morphological analysis showed irregular shape and size, with crystallinity of 57.77 % and an average particle size of 230.9 nm. Tests on vaname shrimp (Litopenaeus vannamei) showed that the ganyong-nanocellulose-curcumin film can monitor the freshness of shrimp through color changes from yellow to red under alkaline conditions, indicating spoilage. Ammonia during spoilage caused weight loss, soft texture, and increased TVBN value. Curcumin-based indicators affect intelligent packaging properties, reducing moisture content, water vapor transmission rate, solubility, and elongation while increasing tensile strength, density, and thickness. This intelligent packaging film has great potential for monitoring seafood freshness, making it a promising innovation.
Antibody-functionalized nanoporous silicon particles as a selective doxorubicin vehicle to improve toxicity against HER2+ breast cancer cells
Authors: Camacho Alma Rosa Oaxaca , Rodríguez Sara Elisa Herrera , Mojica Óscar René Ochoa , Agarwal Vivechana , Pelayo Alexis Jazmín Preciado , Arízaga Gregorio Guadalupe Carbajal , Álvarez Ángel H. , Carvajal Zaira Yunuen García , Velázquez Moisés Martínez , Gutiérrez Rodolfo Hernández 
Published: February 2025

Abstract
Porous silicon (PS) has been widely used in biology, biomedicine, and nanotechnology. In recent years, its application in cancer therapy has received considerable attention. PS has shown low cytotoxicity, so it is reasonable to use it as an antibody conjugate for targeted anticancer drug delivery. In this work, we synthesized PS covalently attached to doxorubicin and covered by a nanometric polymer as a crosslinker between PS and the monoclonal antibody trastuzumab, using electrochemical etching for particle generation. The results revealed the formation of the antibody conjugate, obtaining particles with sizes around 250–350 nm, and a homogeneous size distribution determined by dynamic light scattering. Scanning electron microscopy (SEM) analyses showed the porous structure of the conjugate, while Fourier-transform infrared and transmission electron microscopy characterization demonstrated functionalization between PS and the antibody. The cytotoxic effect was evaluated against two breast cancer cell lines, SKBR3 (HER2+) and MCF-7 (HER2−), and one non-cancer cell line as control (HEK293). The cytotoxic effect on the SKBR3 cancer cell line was higher than on the MCF-7 and HEK293 cell lines. Notably, the targeted protein HER2 mediates the elevated cytotoxic activity exhibited by the antibody conjugate.
Pediatric Cholecystectomy Case Volume and Complexity Following the COVID-19 Pandemic
Authors: Keane Olivia A. , Ourshalimian Shadassa , Ignacio Romeo , Acker Shannon , Jensen Aaron , Lofberg Katrine , Mueller Claudia , Padilla Benjamin E. , Pandya Samir , Rothstein David H. , Russell Katie W. , Smith Caitlin , O’Guinn MaKayla , Ing Madeleine , Floan Sachs Gretchen , Highet Alexandra , Iantorno Stephanie E. , Templeton Lauren R. , Ochoa Brielle , Patwardhan Utsav M. , Peace Alyssa , Schwab Marisa E. , Tran Tina H. , Kelley-Quon Lorraine I. 
Published: February 2025

BACKGROUND AND OBJECTIVES
Historically, cholecystectomy was infrequently performed in children. Lifestyle changes, delays in health care access, and increases in childhood obesity occurred during the COVID-19 pandemic. The impact of these shifts on need for cholecystectomy are poorly understood. We evaluate trends in cholecystectomy case volume among children during the COVID-19 pandemic.

METHODS
A multi-institutional retrospective cohort study was conducted for children ages 18 years and younger who underwent cholecystectomy from January 1, 2016, to July 31, 2022, at 10 children’s hospitals. Differences in cholecystectomy case mix and volume before and during the pandemic were identified using bivariate comparisons and interrupted time series analysis.

RESULTS
Overall, 4282 children were identified: 2122 before the pandemic and 2160 during the pandemic. Most were female (74.2%) with a median age of 15 years (IQR, 13.0–16.0 years). The proportion of Hispanic (55.0% vs 60.1%; P = .01) patients, body mass index (BMI) (26.0 vs 27.1; P &lt; .001), and obesity (BMI &gt; 30) (30.8% vs 37.4%; P &lt; .001) increased during the pandemic. Predicted monthly case volume increased from 40 to 100 during the pandemic. Patients transferred from an outside hospital increased (21.3% vs 28.5%; P &lt; .001). Significant increases in acute cholecystitis (12.2% vs 17.3%; P &lt; .001), choledocholithiasis (12.8% vs 16.5%; P = .001), gallstone pancreatitis (10.6% vs 12.4%; P = .064), and chronic cholecystitis (1.4% vs 3.2%; P &lt; .001) also occurred. On interrupted time series analysis, change in month-to-month case count significantly increased during the pandemic (Figure 1; P &lt; .001), which persisted after exclusion of transferred patients.

CONCLUSIONS
Pediatric cholecystectomy case volume and complexity increased during the COVID-19 pandemic. These findings may be secondary to changes in childhood health, transfer patterns, and shifts in access, highlighting an increased health care burden on children’s hospitals.
Los apuntes de un masón: Reflexiones en torno a un cuaderno de notas de finales del siglo XIX y principios del siglo XX
Authors: Oviedo Salazar Mauricio 
Published: February 2025

El artículo se concentra en un cuaderno de notas atribuido al pintor, masón y teósofo, Tomás Povedano, utilizado desde finales del siglo XIX y principios del XX. Si bien la atribución no se puede asegurar con certeza, podemos decir que es el cuaderno de apuntes de un masón o de un aspirante a masón. Las anotaciones están comprendidas por textos y dibujos de disímiles fuentes, la mayoría de ellas explícitamente masónicas. El presente análisis pretende primero, dar a conocer los contenidos del cuaderno, y posteriormente, analizar estos como elementos clave sobre los intereses prácticos, simbólicos, experienciales de la masonería.
A Content Analysis of Neurodiversity Constructs in Counseling Journals
Authors: Long Susan M. , Clark Madeline , Ausloos Clark D. , Paul Dinisha , Finch Kaylee 
Published: February 2025

Abstract
This qualitative content analysis provides an overview of neurodiversity constructs published in 21 peer-reviewed counseling journals between 2013 and 2022. A total of 33 articles met inclusion criteria and were analyzed. The publishing journal, year published, article type, article purpose, neurodiversity terminology, populations studied, and counseling application are identified. Findings of this content analysis revealed 14 of 21 counseling journals published articles pertinent to neurodiversity constructs within a 9-year period, with a slight increase in neurodiversity-related articles published during this time span. Implications such as increasing discussions of neurodiversity in counseling, applying a neurodiversity paradigm in clinical practice, and a call for counseling outcome research about neurodiversity are discussed.
Psychometric Evaluation of Wellness-Based Screeners: National Sample of U.S. Physicians
Authors: Kalkbrenner Michael T. , Sun Hannah , Peterson Sage 
Published: February 2025

Abstract
Total wellness (mental and physical health) is a core element and a foundational pillar in the mental health counseling field. The counseling literature is lacking research on supporting physicians in the United States, who are a unique population facing complex mental and physical health issues. Health-based screening has notable utility for monitoring and promoting physician wellness. However, the literature is missing a package of health-based screeners with valid scores among a normative sample of U.S. physicians. We tested the psychometric properties of the following wellness-based screeners with a national sample of U.S. physicians: Mental Health Inventory–5, Lifestyle Practices and Health Consciousness Inventory–2, and Inner Wealth Inventory. Results revealed support for convergent validity and factorial invariance of physicians’ scores on all three screeners by gender identity and help-seeking history. We offer recommendations for how these wellness-based screeners can edify the practice of mental health counselors when working with physician clients.
Reflexões Sobre o Processo de Ensinagem de Histologia na Perspectiva das Novas Teorias da Aprendizagem
Authors: Silva Marcia Maria , Biberg-Salum Tânia Gisela 
Published: February 2025

Partindo da experiência de mais de vinte anos como docente em um curso de Medicina baseado em um currículo integrado e metodologias inovadoras que privilegiam o protagonismo de aluno e, a partir da própria atuação no processo de ensino das Ciências Morfológicas Microscópicas (Histologia e Patologia), a pesquisadora observou sinais de desmotivação e evasão dos alunos neste cenário. Aventou a hipótese de que o predomínio de aulas teóricas, sustentadas pelo método de ensino tradicional, poderiam ser o gatilho para tal possibilidade. Esta reflexão suscitou o desejo de promover uma renovação nas suas práticas docentes. Assim, o objetivo deste trabalho centra-se em revisar os conceitos teóricos das Novas Teorias da Aprendizagem, com um recorte voltado para o ensino das Ciências Morfológicas, a fim de fundamentar o planejamento de futuras ações voltadas para o processo de ensinagem de Histologia e Patologia. Conduzido a partir de uma pesquisa qualitativa, pautado em revisão da literatura, levantou textos científicos na base de dados Google Scholar que constituíram uma base reflexiva e interpretativa dos estudos de Dewey, Bruner e Ausubel, a fim de suscitar uma proposta aplicável para o processo de ensino e aprendizagem das Ciências Microscópicas que seja significativo, colaborativo e baseado no aluno como protagonista.
Palavras-chave: Ensino. Formação Docente. Ciências Microscópicas. Aprendizagem Significativa. Metodologias Ativas.
Abstract
Based on the experience of more than twenty years as a teacher in a Medicine course based on an integrated curriculum and innovative methodologies that privilege student protagonism and, based on his own performance in the teaching process of Microscopic Morphological Sciences (Histology and Pathology), the researcher observed signs of demotivation and dropout among students in this scenario. He hypothesized that the predominance of theoretical classes, supported by the traditional teaching method, could be the trigger for such a possibility. This reflection gave rise to the desire to promote a renewal in their teaching practices. Thus, the objective of this work focuses on reviewing the theoretical concepts of New Learning Theories, with a focus on the teaching of Morphological Sciences, in order to support the planning of future actions aimed at the teaching process of Histology and Pathology . Conducted from qualitative research, based on a literature review, it collected scientific texts in the Google Scholar database that constituted a reflective and interpretative basis for the studies of Dewey, Bruner and Ausubel, in order to raise an applicable proposal for the process of teaching and learning of Microscopic Sciences that is meaningful, collaborative and based on the student as the protagonist.
Keywords: Teaching. Teacher Training. Microscopic Sciences. Meaningful Learning. Active Methodologies.
Efecto de los ácidos grasos omega 3 sobre la inflamación en fibrosis quística: revisión sistemática cualitativa
Authors: Coss-Borbón Araceli , Quintero-Martínez Carlos , Olivas-Aguirre Francisco , Márquez Ibarra Adriana Alejandra 
Published: February 2025

INTRODUCCIÓN: Los pacientes con fibrosis quística (FQ) presentan una enfermedad hereditaria autosómica recesiva caracterizada por un desequilibrio de agua, electrolitos y moco en múltiples órganos, que se asocia una alta afluencia de células y mediadores inflamatorios persistentes. Evaluaciones recientes han empleado ácidos grasos esenciales (omega 3) como agentes inmunomoduladores, sin embargo, en la actualidad aún no se tiene suficiente evidencia para su recomendación en pacientes con FQ.
OBJETIVO: Evaluar los estudios clínicos aleatorizados que han empleado ácidos grasos omega-3 como terapia sobre la inflamación en pacientes con fibrosis quística.
MATERIAL Y MÉTODOS: Se realizó una revisión sistemática cualitativa de acuerdo con los elementos considerados para la planeación de una revisión sistemática por Cochrane, en la cual se incluyeron Estudios Clínicos Aleatorizados (ECA) doble o triple ciego con antigüedad menor a 10 años.
RESULTADOS: Tres ECA con buena calidad científica presentaron efectos positivos sobre biomarcadores inflamatorios. Los principales hallazgos involucraron una mejora en el perfil de ácidos grasos circulantes y eritrocitarios ((incremento en el ácido docosahexaenoico (DHA) y disminución del ácido araquidónico). Consecuentemente esta relación mejora múltiples indicadores como Interleucina-6 (IL-6) y elastasa leucocitaria humana. Las principales limitaciones involucran la carencia de un biomarcador específico para evaluar mejoras antiinflamatorias en la FQ.
CONCLUSIÓN: La suplementación a largo plazo con DHA puede mejorar la inflamación en la fibrosis quística. La regulación de la actividad leucocitaria y perfil de ácidos grasos proinflamatorios parecen ser responsables de los efectos observados.
EVOLUSI SISTEM PEMERINTAHAN ISLAM: Studi Kasus Kesultanan Syafawi di Persia
Authors: Syarifah Hasnia Imroatis 
Published: February 2025

Setelah Mongol dan Timuriyah, Safawi sebagai imperium Islam juga mulai menguasai Iran. Sebelum menjadi kesultanan yang berpengaruh besar di Iran, Safawiyah merupakan sebuah gerakan tarekat. Syekh Safi al-Din merupakan penggagas sekaligus pemimpin gerakan tarekat Safawiyah. Ia merupakan seorang sufi yang berasal dari suku Kurdi. Namun, seiring berjalannya waktu gerakan tarekat ini berubah menjadi kekuatan dinasti baru di Iran yang kelak akan berhasil menguasai Iran hampir se abad lamanya. Safawiyah berhasil mengambil kesempatan atas hancurnya rezim Timuriyah. Shah Ismail berhasil mengesahkan Kesultanan Safawi yang didirkannya di Persia pada tahun 1501 M. dengan mengadopsi Syiah Istna Asyariah sebagai ideologi negara. Di Kota Tabriz, Syah Ismail mendeklarasika diri sebagai raja pertama Dinasti Safawi yang dikenal dengan Ismail. Mengenai pendekatan yang digunakan oleh penulis adalah pendekatan kualitatif dengan metode riset kepustakaan yang menggunakan beberapa buku sejarah internasional serta jurnal-jurnal bereputasi sebagai referensi dan komponen pendukung penulisan. Adapun tujuan penelitian ini adalah mengetahui analisa fase dan sistem pemerintahan Kesultanan Safawi. Hasil penelitian menunjukkan bahwa keberhasilan yang dilalui oleh pemerintahan Kesultanan Safawi berpatokan pada angkatan bersenjata dimana langkah pertama yang disiapkan oleh Syah Abbas sebagai sultan yang mencapai kesuksesan ialah tentara yang kuat. Bahkan Kesultnan Safawi menjadikan bekas tawanan perang orang Kristen sebagai tentara dengan julukan ghulam. Setelah Kesultanan Safawi mencapai puncak kesuksesan di masa Sultan Syah Abbas I banyak sekali perbaikan yang dilakukannya dalam dunia politik dan pemerintaan kerajaan. Namun setelah Syah Abbas I wafat, tidak ditemukan sultan yang mampu memimpin secakap Syah Abbas I sehingga membawa Kesultanan Safawi diambang kehancuran.
How Will You Hear My Voice? The Development of Indigenous-Centred Supported Decision-Making for Mental Health Service Users in Aotearoa New Zealand
Authors: Lenagh-Glue Jessie , Tamatea Armon , O'Brien Anthony , Glue Paul , Potiki Johnnie , Newton-Howes Giles , Thom Katey , Gledhill Kris , Gordon Sarah 
Published: February 2025

There is an urgent need in the delivery of mental health services to incorporate a more human-rights oriented approach, and promote supported decision-making, whereby individuals are supported their own mental health decisions based on their will and preferences. Aotearoa/New Zealand’s current Mental Health Act enables the use of compulsory treatment, which breaches both international obligations under the Convention of the Rights of Persons with Disabilities and the principles of Te Tiriti o Waitangi (the Treaty of Waitangi), the covenant between Māori and the Crown which demands partnership and equity and the principle of self-determination for Māori. Mental Health Advance Preference Statements (MAPS) have been identified as a tool to promote supported decision-making and allow people a voice in their own care. This paper examines the foundations of a new project which is Māori-centred and co-produced with stakeholders, including tāngata whaiora who experience mental distress and those who work and research mental health services. The aim of this project is to create and implement culturally appropriate and locally relevant MAPS-type tools and then evaluate the impact of implementation. It is posited this will lead to improvements in health and equity, particularly for Māori.
Sirtuins in Cardiorenal Diseases: A Narrative Review
Authors: Carollo Caterina , Sorce Alessandra , Cirafici Emanuele , Mulè Giuseppe , Caimi Gregorio 
Published: February 2025

Aging is a very complex process and it has been linked with Sirtuins. Sirtuin enzymes are a family of deacetylases that are related with caloric restriction and aging by modulating energy metabolism, genomic stability and stress resistance. Up to now, seven sirtuins have been recognized. Our purpose is to clarify the role of sirtuins in Chronic Kidney Disease (CKD). Moreover, as heart and kidney diseases are strictly interrelated, we’re going to explore their role in heart diseases and cardio-renal cross-talk. A reciprocal relationship between CKD and aging seems to exist, since CKD may contribute to premature biological aging of different organ systems. SIRTs are involved in pathophysiology of renal diseases; their activation can delay the progression of several renal diseases. Cardiovascular diseases (CVDs) are the leading cause of global mortality and a major contributor to disability. Notably, an increasing number of studies linked SIRTs with different CVDs. SIRTs affect the production of mitochondrial reactive oxygen species (ROS) by modulating mitochondrial function. The imbalance of SIRTs levels may increase the vulnerability to CVDs. SIRTs are involved in pathophysiological mechanisms of HFpEF (heart failure with preserved ejection fraction) through different signalling pathways. Fibrosis is the linkage mechanism between heart and kidney in the development of cardio-renal diseases. Different natural SIRT1 agonists showed renoprotective effects and among these Resveratrol (RSV) and other phenolic compounds have been widely investigated with interesting and positive results. Future research is obviously needed to clarify the role of these molecules and their potential therapeutical role in heart and kidney diseases.
Impact of Delayed Centrifugation on Interleukin 6 Determination in Human Blood
Authors: Sauerwein Hannah L , Hermsen Derik F , KIndgen-Milles Detlef , Michael Erik , Fischer Johannes C , Boege Fritz 
Published: February 2025

Background/Objectives: Clinical experience indicates that determination of interleukin 6 (IL-6) in human blood can vary depending on time span between sample collection and centrifugation. Here, we have evaluated that confounding effect in various blood specimen. Methods: Measurement of IL-6 before and after pre-centrifugation incubation (20 °C, 24 - 72 h) in heparin-plasma, serum and EDTA-plasma from healthy individuals and critical ill patients. Results: Pre-incubation induced IL-6 increases in heparin-plasma (in 17/20 samples up to 50-fold) and serum (in 17/20 samples up to 12-fold). Normal values were thereby lifted above the confidence limit in 12/20 heparin plasma samples and 4/20 sera. The observed increases are probably due to in vitro synthesis/incretion as opposed to release of cell-bound IL-6, because microbial stimulators evoked &amp;gt; 1000-fold increases while cell lyses had negligible effects on IL-6. In EDTA-plasma, pre-incubation induced IL-6 decreases by up to 30 % in 17/20 samples, which entailed one false-negative result. Conclusions: IL-6 determination in heparin-plasma and serum is significantly compromised by delayed centrifugation, which increases the rate of false-high results by &gt; 50 %. IL-6 determination in EDTA-plasma is less affected by delayed centrifugation, which decreases the results moderately but induces false-negative results in &lt; 10% of cases.
Uplift History of the Eastern Pamir Inferred from Inversion of Thermochronometric Data and River Profile
Authors: Wu Yunpeng , Yang Rong , Jiao Ruohong , Lin Xiubin , Chen Hanlin , Gong Junfeng , Shi Xuhua 
Published: February 2025

Abstract
The Pamir salient accommodates a great amount of Cenozoic India-Eurasia convergence in the forms of thrusting, strike-slip faulting, extension, and gneiss dome formation. It thus becomes a key location for exploring the orogenic tectonic evolution. Here, we focus on the Eastern Pamir where extensional deformation dominates during the late Cenozoic. We conducted low-temperature thermochronological dating on bedrock samples collected from the footwall of the Kongur Shan normal fault together with inversion of the longitudinal river profile of the Gez River. Our new zircon and apatite (U-Th)/He (ZHe and AHe) data reveal young ages in proximity to the normal fault and older ages adjacent to the western Tarim Basin. By inverting the Gez River profile together with published and new thermochronological ages, we obtained a sustained uplift rate of ~3 mm/yr in the Kongur Shan dome since ~8 Ma, contrasting with no significant uplift to the east of the dome before the Pliocene. This uplift pattern can be interpreted as a result of the upward extrusion of crust materials along a flat–ramp–flat thrust fault at depth under the context of convergence.