bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications
Authors: Luo Zhiqiang , Wang Yu , Li Jinbo , Wang Jinglin , Yu Yunru , Zhao Yuanjin 
Published: September 2023

AbstractHyaluronic acid (HA) is an attractive anionic polysaccharide polymer with inherent pharmacological properties and versatile chemical groups for modification. Due to their water retention ability, biocompatibility, biodegradation, cluster of differentiation‐44 targeting, and highly designable capacity, HA hydrogels have been an emerging biomaterial, showing tailoring performance in terms of chemical modifications and hydrogel forms. Various preparation technologies have been developed for the fabrication of the tailoring HA hydrogels with unique structures and functions. They have been utilized in diverse biomedical applications like drug delivery and tissue engineering scaffolds. Herein, this review comprehensively summarizes the HA derivatives with different molecule weights and functional modifications. Then the various fabrication methods to obtain tailoring hydrogels in the forms of nanogel, nanofiber, microparticle, microneedle patch, injectable hydrogel, and scaffold are reviewed as well. The emphasis is focused on the shining biomedical applications of these tailoring HA hydrogels in anti‐bacteria, anti‐inflammation, wound healing, cancer treatment, regenerative medicine, psoriasis treatment, diagnosis, etc. The potentials and prospects are subsequently given to inspire further investigation, aiming at accelerating product translation from research to clinic.
Development of Electrochemical Anion Doping Technique for Expansion of Functional Material Exploration
Authors: Katsumata Takuya , Yamamoto Hajime , Kimura Yuta , Amezawa Koji , Aso Ryotaro , Kikkawa Soichi , Yamazoe Seiji , Nakamura Takashi 
Published: September 2023

AbstractInstead of conventional cation doping strategy, anion doping is a promising new strategy for advances of energy conversion and storage technologies such as batteries, catalysts, electrolysis, and fuel cells. To synthesize mixed‐anion compounds, novel synthesis techniques such as topochemical reaction, high‐pressure reaction, solvothermal reaction have been developed. Despite these excellent synthesis techniques, synthesizable mixed‐anion compounds are still limited. For further expansion of the material exploration of mixed‐anion compounds, herein, an electrochemical anion doping technique is developed, which can flexibly control a species of anion, the doping rate and the degree of anion doping. The concept of the new synthesis technique is verified by F doping to the perovskite oxide La0.5Sr0.5CoO3−δ. Quantitative control of F in the perovskite host material is succeeded by using an electrochemical reactor composed of La0.5Sr0.5CoO3−δ‐BaF2|BaF2|PbF2‐Pb, and phase‐pure F‐doped La0.5Sr0.5CoO3−δ powder is obtained. Moreover, nano‐size crystalline domains with amorphous phase are formed on the particle surface under the high‐rate F doping, suggesting that tuning the anion doping rate enables the control of the formation of metastable phase. As demonstrated, the electrochemical anion doping technique opens up new possibilities for advances of energy materials by utilizing function of anionic species.
Double Emulsion‐Mediated Delivery of Polyphenol Mixture Alleviates Atopic Dermatitis
Authors: Choi Subin , Ko Junghyeon , Park Su‐Bin , Kim Joo‐Young , Ha Jung‐Hwa , Roh Sangho , An Young‐Hyeon , Hwang Nathaniel S. 
Published: September 2023

AbstractAlthough the polyphenols have been studied to alleviate inflammation, there are still challenges to delivering the polyphenols with stabilized formulation due to their low water solubility and susceptibility to oxidation. Herein, the transdermal delivery system of polyphenol mixture (PM), including quercetin (Q), phloretin (P), and ellagic acid (E), is developed using double emulsion for applying to atopic dermatitis (AD). Through the in vitro anti‐degranulation assay, the optimal molar ratio of each polyphenol (Q:P:E = 5:1:1) is obtained, and the PM shows at most a 43.6% reduction of degranulation of immune cells, which is the primary factor of AD. Moreover, the water‐in‐oil‐in‐water double emulsion (W/O/W) enhances the PM's stability and has a higher anti‐degranulation effect than the oil‐in‐water emulsion (O/W). In the in vivo 1‐chloro‐2,4‐dinitrobenzene (DNCB)‐induced mice AD model, PM reduces more AD symptoms than every single polyphenol. The PM‐encapsulated W/O/W (PM_W/O/W) shows the most effectiveness in AD by decreasing dermatitis score, i.e., skin/ear thickness, mast cells, and serum IgE level. Finally, this suggests that the findings on the optimal ratio of PM and double emulsion‐based delivery would be beneficial in treating AD and can be applied to other allergic diseases.
Optimizing Crystallization in Wide‐Bandgap Mixed Halide Perovskites for High‐Efficiency Solar Cells
Authors: An Yidan , Zhang Nan , Zeng Zixin , Cai Yating , Jiang Wenlin , Qi Feng , Ke Lingyi , Lin Francis R. , Tsang Sai‐Wing , Shi Tingting , Jen Alex K.‐Y. , Yip Hin‐Lap 
Published: September 2023

AbstractWide‐bandgap (WBG) perovskites have attracted considerable attention due to their adjustable bandgap properties, making them ideal candidates for top subcells in tandem solar cells (TSCs). However, WBG perovskites often face challenges such as inhomogeneous crystallization and severe nonradiative recombination loss, leading to high open‐circuit voltage (VOC) deficits and poor stability. To address these issues, a multifunctional phenylethylammonium acetate (PEAAc) additive that enhances uniform halide phase distribution and reduces defect density in perovskite films by regulating the mixed‐halide crystallization rate, is introduced. This approach successfully develops efficient WBG perovskite solar cells (PSCs) with reduced VOC loss and enhanced stability. By applying this universal strategy to the FAMACsPb(I1−xBrx)3 system with a range of bandgaps of 1.73, 1.79, 1.85, and 1.92 eV, power conversion efficiencies (PCE) of 21.3%, 19.5%, 18.1%, and 16.2%, respectively, are attained. These results represent some of the highest PCEs reported for the corresponding bandgaps. Furthermore, integrating WBG perovskite with organic photovoltaics, an impressive PCE of over 24% for two‐terminal perovskite/organic TSCs, with a record VOC of ≈ 2.2 V is achieved. This work establishes a foundation for addressing phase separation and inhomogeneous crystallization in Br‐rich perovskite components, paving the way for the development of high‐performance WBG PSCs and TSCs.
Self‐Reaction Effect‐Boosted Liquid Thermocell Based on Ethanol‐Aqueous Biphasic System
Authors: Liu Xiangyu , Wang Taiyu , Fang Jiale , Fan Feng Ru 
Published: September 2023

AbstractLow‐grade heat (<100 °C) energy sources possess considerable untapped potential for sustainable power generation. Liquid thermocells (LTCs) represent an innovative solution to convert low‐grade heat into electricity. The performance of LTCs relies on the combined effects of the Seebeck coefficient (Se), electrical conductivity (σeff), and thermal conductivity (κeff). While previous studies have predominantly focused on enhancing Se and σeff, κeff has received limited attention. Therefore, in this study, an electrochemically active biphasic liquid thermocell (EAB‐LTC) composed of ferrocene (Fc) and in an ethanol‐aqueous biphasic system is proposed. The self‐reaction of the redox couple enhances Se, while the biphasic nature of the system suppresses thermal convection, resulting in reduced κeff. Compared to the conventional single‐phase LTC utilizing / , the Se is increased by nearly threefold, accompanied by a more than threefold enhancement in output power. The application of the EAB‐LTC module is successfully demonstrated in powering electronic devices, thereby establishing a novel pathway for advancing high‐performance LTCs and presenting a promising approach toward achieving carbon neutrality.
Co‐Catalyzed Reductive Cross‐Couplings of Csp3−S with Callyl−O Electrophiles to form Csp3−Csp3 Bonds
Authors: Gao Mengyu , Gosmini Corinne 
Published: September 2023

AbstractCross‐electrophilic coupling of various benzyl sulfonium salts with Callyl−O electrophiles is described using a simple Co−Mn catalytic system. This catalytic system is able to activate both the stable Csp3−S bond of sulfonium salts and the Csp3−O bond of allylic acetate or ether under mild reaction conditions to form various functionalized alkyl olefinic compounds. Allyl methyl ethers were employed for the first time in transition metal‐catalyzed cross‐electrophilic coupling to build Csp3−Csp3 bonds. Preliminary mechanistic studies suggested the involvement of benzyl radicals generated from C−S bond cleavage through a single electron transfer.
The Role of Extracellular Vesicles in Tumor Therapy and Imaging
Authors: Feng Ting , Wan Yilin , Cui Shengsheng , Liu Yanlei 
Published: September 2023

AbstractCancer is a major disease that poses a serious threat to human health. The therapy and imaging methods of cancer are still widely studied as hotspots for numerous researchers. In particular, the rapid development of nanoscience and technology provide new strategies for tumor therapy and imaging. Extracellular vesicles (EVs) are suggested as potential tumor therapy and imaging tools due to the low immunogenicity, good biocompatibility, high safety, and their natural ability to penetrate biological barriers. This review summarizes the applications of EVs originating from different sources in tumor therapy and imaging, and proposes the advantages and remaining limitations of EVs in this field. EVs from different sources show unique strengths and delivery potentials in tumor‐related research. By focusing on the selection of suitable sources of EVs for therapy and imaging under different conditions, this work expects to provide more knowledge on the potential of EVs in the medical application in the future.
Molecular dynamics predictions of viscosity for organophosphorus liquids
Authors: Ivanova Ella V. , Gor Gennady Y. 
Published: September 2023

AbstractWhen studying physical properties of highly toxic chemicals, such as chemical warfare agents (CWAs), molecular dynamics (MD) simulations can serve as an alternative to experimental measurements. We performed MD simulations to calculate viscosity of four organophosphorus liquids, CWAs, sarin, and soman, as well as their simulants, DMMP and DIMP, in the temperature range from 0 to . The molecules were represented with Transferable Potentials for Phase Equilibria United Atom (TraPPE‐UA) force field; the calculations were performed using the Green–Kubo method. The results for sarin and DMMP are in good agreement with previously published experimental data, which justifies the use of the TraPPE‐UA force field for other organophosphorus compounds. Therefore we predicted viscosity of DIMP and soman, for which the experimental data were unavailable. Our results suggest that for applications where liquid viscosity is important, DMMP is a suitable simulant for sarin, and DIMP is a suitable simulant for soman.
Data‐driven integrated design of solvents and extractive distillation processes
Authors: Wang Zihao , Zhou Teng , Sundmacher Kai 
Published: September 2023

AbstractAs property and process models with many variables need to be considered, integrated computer‐aided molecular and process design (CAMPD) problems are computationally expensive. An efficient CAMPD approach is proposed for the simultaneous design of solvents and extractive distillation (ED) processes based on a data‐driven modeling strategy. First, artificial neural network (ANN)‐based process models are trained to replace the physical models conventionally used in CAMPD. Subsequently, optimization is performed to maximize process performance, through which optimal solvent properties and corresponding optimal process parameters are obtained. Then, real solvents approximating the optimal property values are identified from a large solvent database. Rigorous simulations of the ED process are performed to evaluate the performance of the optimal solvents and corresponding process parameters. Further economic evaluation (6.11% lower annual cost compared to the benchmark process) and chemical hazard assessment confirm that acetylacetone is a promising solvent for the ED separation of 1‐butene from 1,3‐butadiene.
Visible Light‐Induced Decarboxylative Peroxidation of Carboxylic Acids: Metal‐Free Synthesis of Benzyl Peroxides
Authors: Lou Chenhao , Feng Yuting , Huang Qiuwei , Lv Leiyang , Li Zhiping 
Published: September 2023

AbstractA visible light‐induced direct decarboxylative peroxidation of carboxylic acids under mild conditions has been disclosed. With this protocol, a variety of readily available carboxylic acids were converted to the peroxidation products in moderate to good yields via decarboxylative radical C−OO bond coupling. Tert‐butyl hydroperoxide acts as both the oxidant and peroxyl source, avoiding the use of transition metals or extra oxidants.
Association between metabolic syndrome and risk of incident dementia in UK Biobank
Authors: Qureshi Danial , Collister Jennifer , Allen Naomi E. , Kuźma Elżbieta , Littlejohns Thomas 
Published: September 2023

AbstractINTRODUCTIONThe association between metabolic syndrome (MetS) and incident dementia remains inconclusive.METHODSIn 176,249 dementia‐free UK Biobank participants aged ≥60 years at baseline, Cox proportional‐hazards models were used to investigate the association between MetS and incident dementia. MetS was defined as the presence of ≥3 of the following: elevated waist circumference, triglycerides, blood pressure, blood glucose, and reduced high‐density lipoprotein cholesterol.RESULTSOver 15 years of follow‐up (median = 12.3), 5255 participants developed dementia. MetS was associated with an increased risk of incident dementia (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.06, 1.18). The association remained consistent when restricting to longer follow‐up intervals: >5 to 10 years (HR: 1.17, 95% CI: 1.07, 1.27) and >10 years (HR: 1.22, 95% CI: 1.12, 1.32). Stronger associations were observed in those with ≥4 MetS components and in apolipoprotein‐E (APOE)‐ε4 non‐carriers.DISCUSSIONIn this large population‐based prospective cohort, MetS was associated with an increased risk of dementia.Highlights
MetS was associated with a 12% increased risk of incident all‐cause dementia.
Associations remained similar after restricting the analysis to those with longer follow‐up.
The presence of four or five MetS components was significantly associated with dementia.
Stronger associations were observed in those with a low genetic risk for dementia.
An internal fraud model for operational losses in retail banking
Authors: Paredes Rocío , Vega Marco 
Published: September 2023

AbstractThis article presents a novel dynamic model for internal fraud losses in the retail banking sector, incorporating internal factors such as ethical quality of workers and bank risk controls. The model's parameters are calibrated for each bank in the Operational Riskdata eXchange (ORX) consortium, based only on publicly available exposure indicators. The model generates simulated internal operational losses, exhibiting standard stochastic properties and tail behavior that closely align with actual operational losses. At an aggregate level, the model endeavors to replicate the average frequency and severity of losses observed within the internal fraud—retail banking category. Moreover, we identify macro‐environmental factors that exert influence over the severity and frequency of model‐simulated losses, consistent with findings in the existing literature.
Evaluating the effectiveness of video feedback to improve cheerleader tumbling skills
Authors: Snapp Sara Kate , Miltenberger Raymond G. , Zerger Heather M. 
Published: September 2023

AbstractThe current study evaluated the effectiveness of video feedback (VF) to improve tumbling skills with three high‐school cheerleaders. Researchers evaluated the effects of VF using a multiple baseline across behaviors design. Results demonstrate that VF was effective in increasing the percentage of correct steps of the target skills for all three participants. This study contributes to the literature on the use of VF as a procedure to increase sports performance.
Influence of menopause on chemotherapy‐induced nausea and vomiting in highly emetogenic chemotherapy for breast cancer: A retrospective observational study
Authors: Yokokawa Takashi , Suzuki Kenichi , Tsuji Daiki , Hosonaga Mari , Kobayashi Kazuo , Kawakami Kazuyoshi , Kawazoe Hitoshi , Nakamura Tomonori , Suzuki Wataru , Sugisaki Takahito , Aoyama Takeshi , Hashimoto Koki , Hatori Masahiro , Tomomatsu Takuya , Inoue Ayaka , Azuma Keiichi , Asano Maimi , Takano Toshimi , Ohno Shinji , Yamaguchi Masakazu 
Published: September 2023

AbstractBackgroundFemale sex and younger age are reported risk factors for chemotherapy‐induced nausea and vomiting (CINV) in highly emetogenic chemotherapy, but the underlying mechanism has not been elucidated. The purpose of this study was to clarify the impact of menopause on CINV.MethodsThis retrospective observational study analyzed data from consecutive patients who received their first cycle of perioperative anthracycline‐based chemotherapy for breast cancer between January 2018 and June 2020. The endpoints were association between CINV (vomiting, ≥Grade 2 nausea, complete response [CR] failure) and menopause as well as the association between CINV and follicle‐stimulating hormone [FSH]/estradiol [E2].ResultsData for 639 patients were analyzed. Among these patients, 109 (17.1%) received olanzapine (four antiemetic combinations) and 530 (82.9%) did not (three antiemetic combinations). Premenopausal state (amenorrhea lasting ≥12 months) was significantly associated with ≥Grade 2 nausea and CR failure in univariate analysis but not in multivariate analysis. The premenopausal FSH/E2 group (defined by serum levels; FSH <40 mIU/mL and E2 ≥20 pg/mL) had a significantly higher rate of ≥Grade 2 nausea than the postmenopausal FSH/E2 group (FSH ≥40 mIU/mL and E2 <20 pg/mL) (48.8% vs. 18.8%, p = 0.023).ConclusionsOur results suggest that changes in FSH and E2 due to menopause may affect the severity of nausea and that FSH and E2 (especially FSH) levels might be useful indicators for CINV risk assessment.
Gastroesophageal reflux disease and risk of cancer: Findings from the Korean National Health Screening Cohort
Authors: Tran Chi Lan , Han Minji , Kim Byungmi , Park Eun Young , Kim Young Il , Oh Jin‐Kyoung 
Published: September 2023

AbstractAimLittle is known about the association of cancers other than esophageal adenocarcinoma with gastroesophageal reflux disease (GERD). This study aimed to examine the association between GERD and the risk of different types of cancer.MethodsA cohort study was conducted using data from the National Health Screening Cohort. We included 10,261 GERD patients and 30,783 non‐GERD individuals who were matched in a 1:3 ratio by age and sex. All participants were followed‐up until cancer diagnosis, death, or end of the study (December 31, 2015). Hazard ratios were calculated using the Cox proportional hazards model, adjusting for smoking and alcohol consumption, physical activity, body mass index, income, area, and Charlson Comorbidity Index.ResultsThe median follow‐up time was 9.9 years. GERD was associated with an increased risk of esophageal (adjusted hazard ratios [aHR] = 3.20 [1.89–5.41]), laryngeal (aHR = 5.42 [2.68–10.96]), and thyroid cancers (aHR = 1.91 [1.55–2.34]) after controlling for all covariates. The results were consistent when examining GERD with esophagitis (K210) and without esophagitis (K219) separately. For thyroid cancer, the results were insignificant after controlling for having ever‐received thyroid biopsy procedures. A dose–response relationship was found between GERD and esophageal cancer as well as laryngeal cancer, with patients with a longer duration of GERD treatment showing a stronger effect. In contrast, GERD was associated with a reduced risk of colorectal (aHR = 0.73 [0.59–0.90]), liver (aHR = 0.67 [0.51–0.89]), and pancreatic cancers (aHR = 0.43 [0.24–0.76]), which might have resulted from differences in healthcare utilization between GERD and non‐GERD groups.ConclusionGERD was associated with an increased risk of esophageal and laryngeal cancers. Additionally, early detection and treatment of precancerous lesions among the GERD group could lead to a lower risk of colorectal, liver, and pancreatic cancers.
Alternative promoters and splicing create multiple functionally distinct isoforms of oestrogen receptor alpha in breast cancer and healthy tissues
Authors: Balcazar Lopez Carlos Enrique , Albrecht Juliane , Hafstað Völundur , Börjesson Freitag Cornelia , Vallon‐Christersson Johan , Bellodi Cristian , Persson Helena 
Published: September 2023

AbstractBackgroundOestrogen receptor alpha (ER) is involved in cell growth and proliferation and functions as a transcription factor, a transcriptional coregulator, and in cytoplasmic signalling. It affects, for example, bone, endometrium, ovaries and mammary epithelium. It is a key biomarker in clinical management of breast cancer, where it is used as a prognostic and treatment‐predictive factor, and a therapeutical target. Several ER isoforms have been described, but transcript annotation in public databases is incomplete and inconsistent, and functional differences are not well understood.MethodsWe have analysed short‐ and long‐read RNA sequencing data from breast tumours, breast cancer cell lines, and normal tissues to create a comprehensive annotation of ER transcripts and combined it with experimental studies of full‐length protein and six alternative isoforms.ResultsThe isoforms have varying transcription factor activity, subcellular localisation, and response to the ER‐targeting drugs tamoxifen and fulvestrant. Antibodies differ in ability to detect alternative isoforms, which raises concerns for the interpretation of ER‐status in routine pathology.ConclusionsFuture work should investigate the effects of alternative isoforms on patient survival and therapy response. An accurate annotation of ER isoforms will aid in interpretation of clinical data and inform functional studies to improve our understanding of the ER in health and disease.
The effect of emotion type and similarity of experience on consumers' willingness to pay for cause‐related products: Construal level perspective
Authors: Luan Chi‐Cheng , Phan The Anh 
Published: September 2023

AbstractInformation complexity hinders consumer processing and reduces positive responses to cause‐related products. Previous studies on cause‐related marketing (CRM) have focused more on messaging effects on reducing information complexity, such as the presentation of the donation amount, cause description, and image displays. This study discusses the effect of construal fit on consumers' willingness to pay (WTP) for products sold through CRM by focusing on the emotional and perceptual aspects of prior experiences. Notably, sadness has a low‐level construal fit with a high similarity of experience, whereas happiness has a high‐level construal fit with a low similarity of experience. Study 1 employs a between‐subjects design, examining how the construal fit influences WTP for cause‐related products. The results of Study 2 reveal that when consumers are in a sad (happy) emotional state, the higher (lower) they perceive the similarity of their experiences with the cause, the greater their WTP increases owing to processing fluency. Study 3 reconfirms the mediating roles of perceptual and conceptual fluency irrespective of text‐based and visual advertisements for CRM, thus showing the robustness of the construal fit effect on the enhancement of the two types of processing fluency across advertising contexts. These findings contribute to the theoretical understanding of the construal fit between emotional and perceptual experiences in enhancing processing fluency in CRM and suggest that marketers can create a teaser ad that induces either a sad or similar experience or a happy or less similar experience before introducing a CRM campaign.