bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of normalization of postoperative carbohydrate antigen 125 levels with treatment failure following uterine artery embolization for adenomyosis
Authors: Liu Song , Peng Chaonan , Wang Zhiliang , Zhou Xi , Zhang Shujuan , Li Guangxue , Yang Bing 
Published: August 2023

AbstractObjectiveTo investigate the association between carbohydrate antigen 125 (CA125) level and adenomyosis treatment failure (TF) after uterine artery embolization (UAE).MethodsWe evaluated 224 patients with symptomatic adenomyosis who underwent UAE between January 2016 and December 2020. Improvements in dysmenorrhea and menorrhagia were assessed on the basis of symptom relief criteria. The factors associated with TF were investigated using a multivariate logistic regression model. Patients were analyzed for preoperative CA125 levels, postoperative CA125 levels, and the normalization of postoperative CA125 levels. Long‐term symptom relief and quality of life after UAE were compared between the groups.ResultsDuring the 24‐month follow‐up, 50 patients (22.3%) experienced TF. Compared to patients in the non‐TF group, those in the TF group had significantly higher preoperative and postoperative CA125 levels (p < 0.05). Multivariate analysis revealed that failure to normalize postoperative CA125 levels was independently associated with an increased risk of TF (34.7% vs. 8.5%, p < 0.001; hazard ratio 3.953, 95% confidence interval 1.567–9.973, p = 0.004). After a 3‐month follow‐up period, patients who normalized their CA125 levels were more likely to achieve complete necrosis on magnetic resonance imaging than those who did not (82.1% vs. 56.8%, p < 0.001). Normalization of postoperative CA125 levels was significantly associated with fewer symptoms and better quality of life 12 months after UAE (p < 0.05).ConclusionsFollowing UAE, normalization of postoperative CA125 levels, rather than absolute values, was the strongest predictive marker of TF.
Getting on top of work‐email: A systematic review of 25 years of research to understand effective work‐email activity
Authors: Russell Emma , Jackson Thomas W. , Fullman Marc , Chamakiotis Petros 
Published: August 2023

AbstractIn the last 25 years, work‐email activity has been studied across domains and disciplines. Yet, despite the abundance of research available, a comprehensive, unifying framework of how work‐email activity positively impacts both well‐being and work‐performance outcomes has yet to emerge. This is a timely and significant concern; work‐email is the most prominent and popular form of work communication but it is still unclear what people need to do to be effective emailers at work. To address this, we undertook a rigorous cross‐disciplinary systematic literature review of 62 empirical papers. Using action regulation theory, we developed a multi‐action, multi‐goal framework and found four ‘super’ actions that consistently predict effectiveness (positive well‐being and work‐performance outcomes). These actions involve: (i) communicating and adhering to work‐email access boundaries; (ii) regularly triaging emails (iii) sending work‐relevant email and (iv) being civil and considerate in work‐email exchanges. We found that super actions are engaged when workers have the resources to appropriately regulate their activity, and can attend to their self, task and social needs. Our framework synthesizes a broad and disparate research field, providing valuable insights and guiding future research directions. It also offers practical recommendations to organizations and individuals; by understanding and encouraging the adoption of work‐email super actions, effective work‐email practices can be enhanced.
Three‐dimensional evaluation of the temporomandibular joints after unilateral surgically assisted rapid maxillary expansion in adults: A preliminary retrospective study
Authors: Karabiber Gülden , Yılmaz Hanife Nuray 
Published: August 2023

AbstractBackgroundUnilateral surgically assisted rapid maxillary expansion (U‐SARME) is a successful method for correction of true unilateral posterior crossbite (TUPC).ObjectivesThis retrospective preliminary study aimed to evaluate the position and morphology of condyles in TUPC cases and the effects of U‐SARME on condyle with the help of cone beam computed tomography (CBCT).MethodsFifteen patients (mean age: 18.69 ± 1.59 years) who were diagnosed as TUPC and undergone U‐SARME were selected. Preoperative (T0) and after 6‐month retention (T1) DICOM data of CBCT images were evaluated with MIMICs version 19.0 software. Condylar morphology (medio‐lateral and antero‐posterior dimensions) and position (anterior, posterior, medial and lateral joint spaces, frontal/axial axis angles, the ratio of posterior to anterior joint space and the percentage of posterior to anterior joint space) were evaluated. Student's t‐test was used for intergroup (crossbite, normal) comparisons. Paired‐samples t‐test was used for intra‐group comparisons (p = .05).ResultsThere were no positional or dimensional asymmetry of the condyles between crossbite and normal sides initially and after expansion. Regarding T0‐T1 changes, while significant increase was determined in medial (0.3 ± 0.29 mm; p = .001) and superior (0.39 ± 0.7 mm; p = .045) joint spaces on crossbite side, posterior (0.79 ± 0.99 mm; p = .008), superior (0.5 ± 0.79 mm; p = .029) and lateral joint spaces (0.31 ± 0.54 mm; p = .042) presented significant increases on normal side. However, no significant changes were found between crossbite and normal sides at T0 and T1.ConclusionsCondyles were symmetrical in true unilateral posterior crossbite cases and the symmetry were not disrupted following U‐SARME.
A comparative evaluation of fracture resistance of tooth restoration complex restored with PEEK and lithium disilicate endocrowns
Authors: Aher Sakshi Vilas , Fulari Deepti , Adaki Raghavendra , Huddar Dayanand , Dhole Rohit , Badadare Mokshada , Sahare Pratiksha 
Published: August 2023

AbstractPurposeThis in vitro study was conducted to compare the fracture resistance of tooth restoration complex restored with polyetheretherketone (PEEK) and lithium disilicate endocrowns.Materials and MethodsA total of 46 extracted premolars were collected and treated endodontically. The teeth were mounted in cylindrical molds using autopolymerizing resin and were prepared for endocrown restoration. Specimens were divided into two groups (n = 23) to receive endocrowns made with two different materials (polyetheretherketone and lithium disilicate). All the specimens were subjected to thermal cycling. The fracture resistance test was carried out using a Universal Testing Machine. Fractographic analysis was carried out using stereomicroscope and scanning electron microscope after load test. The values obtained were subjected to statistical analysis. Intergroup comparison (two groups) was performed using a t‐test. Comparison of frequencies of categories of variables with groups was performed using chi‐square test.ResultsFracture resistance tests showed a statistically significant difference in values between the two groups (p < 0.01). High fracture resistance values were seen with lithium disilicate endocrowns. Failure mode analysis showed that both groups exhibited mainly catastrophic failure. There were no significant differences in frequencies of the type of fracture between the groups.ConclusionThe fracture resistance of endocrowns fabricated with lithium disilicate material was found to be significantly higher than polyetheretherketone (PEEK) material. Hence, lithium disilicate material is superior for endocrowns.
Using the quality of life framework to operationalize and assess the CRPD articles and the Sustainable Development Goals
Authors: Gómez Laura E. , Morán M. Lucía , Navas Patricia , Verdugo Miguel Ángel , Schalock Robert L. , Lombardi Marco , Vicente Eva , Guillén Verónica M. , Balboni Giulia , Swerts Chris , Al‐Halabí Susana , Alcedo M. Ángeles , Monsalve Asunción , Brown Ivan 
Published: August 2023

AbstractThis article describes how rights, the United Nations Sustainable Development Goals (SDGs), and the quality of life (QOL) framework are closely interrelated. Although legislation can be used as a tool for the practical application of QOL principles, QOL assessment information is required to further develop legislation and monitor the fulfillment of laws, policies, and the SDGs. A validated QOL model, which provides a set of concepts that can be one useful way for understanding and assessing QOL, can also function to assess many of the rights and goals promulgated in the Convention on the Rights of Persons with Disabilities (CRPD) and in the SDGs. This article illustrates the overlap between the CRPD, SDGs and QOL using the #Rights4MeToo Scale, a new measurement instrument for people with intellectual and developmental disabilities (IDD). The instrument's value lies in its potential to: (a) raise awareness about the rights enshrined in the CRPD; (b) design, implement, and evaluate the effectiveness of interventions aimed at facilitating the exercise of those rights and the achievement of the SDGs; and (c) ultimately improve the QOL of people with IDD.
Real‐world epidemiology, treatment patterns and disease burden of patients diagnosed with chronic hepatitis B in Taiwan
Authors: Chien Hsiu‐Ting , Su Tung‐Hung , Huang Hazel , Chiang Chih‐Lin , Lin Fang‐Ju 
Published: August 2023

AbstractBackground and AimsThis study aimed to update the epidemiology, clinical, and economic outcomes of patients diagnosed with chronic hepatitis B (CHB) infection in Taiwan.MethodsThis is a retrospective observational study using claims data from the National Health Insurance Research Database. Cases were identified between 2010 and 2019 using CHB diagnosis codes and claims for alanine aminotransferase laboratory tests or CHB treatment within one year of the first CHB diagnosis. Patient characteristics, epidemiology, clinical, and economic outcomes were described.ResultsA total of 730 154 CHB‐diagnosed cases were identified. The prevalence of diagnosed CHB increased from 1.13% in 2010 to 2.43% in 2019, with the highest occurring among those aged 55–64 years (4.76%) and 45–54 years (4.37%) and being higher in men (2.98%) than in women (2.21%). The majority of newly diagnosed CHB patients were 35 years of age or older (86.6%), with a median age of 49 years. After a median follow‐up period of 6.42 years, 12.5%, 7.9%, 2.8%, and 0.35% were diagnosed with cirrhosis, decompensated cirrhosis, hepatocellular carcinoma, and liver transplantation respectively. Among 456 706 incident CHB‐diagnosed patients, 17.4% had received at least one CHB medication, with the majority taking entecavir (67.9%). Patients with increasing disease severity had higher healthcare resource utilization, and inpatient costs accounted for 48.9%–65.5% of the overall medical cost in different health states.ConclusionDespite the decreasing incidence of newly diagnosed CHB, the prevalence of diagnosed CHB remains high and poses a significant healthcare challenge owing to the high economic burden associated with the complications of CHB.
Different trematode parasites in the same snail host: Species‐specific or shared microbiota?
Authors: Salloum Priscila M. , Jorge Fátima , Poulin Robert 
Published: August 2023

AbstractThe concept that microbes associated with macroorganisms evolve as a unit has swept evolutionary ecology. However, this idea is controversial due to factors such as imperfect vertical transmission of microbial lineages and high microbiome variability among conspecific individuals of the same population. Here, we tested several predictions regarding the microbiota of four trematodes (Galactosomum otepotiense, Philophthalmus attenuatus, Acanthoparyphium sp. and Maritrema novaezealandense) that parasitize the same snail host population. We predicted that each parasite species would harbour a distinct microbiota, with microbial composition similarity decreasing with increasing phylogenetic distance among parasite species. We also predicted that trematode species co‐infecting the same individual host would influence each other's microbiota. We detected significant differences in alpha and beta diversity, as well as differential abundance, in the microbiota of the four trematode species. We found no evidence that phylogenetically closely related trematodes had more similar microbiota. We also uncovered indicator bacterial taxa that were significantly associated with each trematode species. Trematode species sharing the same snail host showed evidence of mostly one‐sided bacterial exchanges, with the microbial community of one species approaching that of the other. We hypothesize that natural selection acting on specific microbial lineages may be important to maintain differences in horizontally acquired microbes, with vertical transmission also playing a role. In particular, one trematode species had a more consistent and diverse bacteriota than the others, potentially a result of stronger stabilizing pressures. We conclude that species‐specific processes shape microbial community assembly in different trematodes exploiting the same host population.
Prevalence of the second victim phenomenon among intensive care unit nurses and the support provided by their organizations
Authors: Kappes Maria , Delgado‐Hito Pilar , Contreras Verónica Riquelme , Romero‐García Marta 
Published: August 2023

AbstractBackgroundHealth professionals can be ‘second victims’ of adverse patient events. Second victimhood involves a series of physical and psychological signs and symptoms of varying severity and is most prevalent among nurses and women and in intensive care units (ICUs). Previous research has described personal and organizational coping strategies.AimThe objective of this research is to determine the prevalence of second victimhood, focusing on psychological distress, among Chilean adult intensive care nurses and its relationship with the support provided by their organizations.Study DesignA descriptive, correlational and cross‐sectional study was conducted in seven intensive care units of Chilean hospitals.ResultsOf a sample of 326 nurses, 90.18% reported having been involved in an adverse event and 67% reported psychological distress resulting from the adverse event. Embarrassment was the most prevalent psychological symptom (69%). Only 2.8% reported that their organization had an action plan for professionals in the event of a serious adverse event. Participants who had spent longer working in an ICU reported more support from their organization around adverse events.ConclusionTwo‐thirds of Chilean adult intensive care unit nurses report psychological stress following an adverse event. These results should be assessed internationally because second victims have major implications for the well‐being of health professionals and, therefore, for retention and the quality of care.Relevance to Clinical PracticeCritical care leaders must actively promote a safe environment for learning from adverse events, and hospitals must establish a culture of quality that includes support programmes for second victims.
Epigenomic divergence correlates with sequence polymorphism in Arabidopsis paralogs
Authors: Kenchanmane Raju Sunil K. , Lensink Mariele , Kliebenstein Daniel J. , Niederhuth Chad , Monroe Grey 
Published: August 2023

Summary

Processes affecting rates of sequence polymorphism are fundamental to the evolution of gene duplicates. The relationship between gene activity and sequence polymorphism can influence the likelihood that functionally redundant gene copies are co‐maintained in stable evolutionary equilibria vs other outcomes such as neofunctionalization.

Here, we investigate genic variation in epigenome‐associated polymorphism rates in Arabidopsis thaliana and consider whether these affect the evolution of gene duplicates. We compared the frequency of sequence polymorphism and patterns of genetic differentiation between genes classified by exon methylation patterns: unmethylated (unM), gene‐body methylated (gbM), and transposon‐like methylated (teM) states, which reflect divergence in gene expression.

We found that the frequency of polymorphism was higher in teM (transcriptionally repressed, tissue‐specific) genes and lower in gbM (active, constitutively expressed) genes. Comparisons of gene duplicates were largely consistent with genome‐wide patterns – gene copies that exhibit teM accumulate more variation, evolve faster, and are in chromatin states associated with reduced DNA repair.

This relationship between expression, the epigenome, and polymorphism may lead to the breakdown of equilibrium states that would otherwise maintain genetic redundancies. Epigenome‐mediated polymorphism rate variation may facilitate the evolution of novel gene functions in duplicate paralogs maintained over evolutionary time.
The neurobiology of vocal communication in marmosets
Authors: Grijseels Dori M. , Prendergast Brendan J. , Gorman Julia C. , Miller Cory T. 
Published: August 2023

AbstractAn increasingly popular animal model for studying the neural basis of social behavior, cognition, and communication is the common marmoset (Callithrix jacchus). Interest in this New World primate across neuroscience is now being driven by their proclivity for prosociality across their repertoire, high volubility, and rapid development, as well as their amenability to naturalistic testing paradigms and freely moving neural recording and imaging technologies. The complement of these characteristics set marmosets up to be a powerful model of the primate social brain in the years to come. Here, we focus on vocal communication because it is the area that has both made the most progress and illustrates the prodigious potential of this species. We review the current state of the field with a focus on the various brain areas and networks involved in vocal perception and production, comparing the findings from marmosets to other animals, including humans.
The influence of electrode‐tissue‐coverage on RF lesion formation and local impedance: Insights from an ex vivo model
Authors: Bahlke Fabian , Wachter Andreas , Erhard Nico , Englert Florian , Krafft Hannah , Popa Miruna , Risse Elena , Kottmaier Marc , Telishevska Marta , Lengauer Sarah , Lennerz Carsten , Reents Tilko , Hessling Gabriele , Deisenhofer Isabel , Bourier Felix 
Published: August 2023

AbstractBackgroundThe influence of power, duration and contact force (CF) on radiofrequency (RF) lesion formation is well known, whereas data on local impedance (LI) and electrode‐tissue‐coverage (ETC) is scarce. The objective was to investigate their effect on lesion formation in an ex vivo model.Methods and ResultsAn ex vivo model was developed utilizing cross‐sections of porcine heart preparations and a force‐sensing, LI‐measuring catheter. N = 72 lesion were created systematically varying ETC (minor/full), CF (1–5 g, 10–15 g, 20–25 g) and power (20 W, 30 W, 40 W, 50 W). In minor ETC, the distal tip of the catheter was in electric contact with the tissue, in full ETC the whole catheter tip was embedded within the tissue. Lesion size and all parameters were measured once per second (n = 3320). LI correlated strongly with lesion depth (r = −0.742 for ΔLI; r = 0.781 for %LI‐drop). Lesions in full ETC were significantly wider and deeper compared to minor ETC (p < .001) and steam pops were more likely. Baseline LI, ΔLI, and %LI‐drop were significantly higher in full ETC (p < .001). In lesions resulting in steam pops, baseline LI, and ΔLI were significantly higher. The influence of CF on lesion size was higher in minor ETC than in full ETC.ConclusionsETC is a main determinant of lesion size and occurrence of steam pops. Baseline LI and LI‐drop are useful surrogate parameters for real‐time assessment of ETC and ΔLI correlates strongly with lesion size.
Prediction of early postoperative pain using sleep quality and heart rate variability
Authors: Ho Chun‐Ning , Fu Pei‐Han , Hung Kuo‐Chuan , Wang Li‐Kai , Lin Yao‐Tsung , Yang Albert C. , Ho Chung‐Han , Chang Jia‐Hui , Chen Jen‐Yin 
Published: August 2023

AbstractPurposeAccurate predictions of postoperative pain intensity are necessary for customizing analgesia plans. Insomnia is a risk factor for severe postoperative pain. Moreover, heart rate variability (HRV) can provide information on the sympathetic–parasympathetic balance in response to noxious stimuli. We developed a prediction model that uses the insomnia severity index (ISI), HRV, and other demographic factors to predict the odds of higher postoperative pain.MethodsWe recruited gynecological surgery patients classified as American Society of Anesthesiologists class 1–3. An ISI questionnaire was completed 1 day before surgery. HRV was calculated offline using intraoperative electrocardiogram data. Pain severity at the postanesthesia care unit (PACU) was assessed with the 0–10 numerical rating scale (NRS). The primary outcome was the model's predictive ability for moderate‐to‐severe postoperative pain. The secondary outcome was the relationship between individual risk factors and opioid consumption in the PACU.ResultsOur study enrolled 169 women. Higher ISI scores (p = 0.001), higher parasympathetic activity (rMSSD, pNN50, HF; p < 0.001, p < 0.001, p < 0.001), loss of fractal dynamics (SD2, alpha 1; p = 0.012, p = 0.039) in HRV analysis before the end of surgery were associated with higher NRS scores, while laparoscopic surgery (p = 0.031) was associated with lower NRS scores. We constructed a multiple logistic model (area under the curve = 0.852) to predict higher NRS scores at PACU arrival. The five selected predictors were age (OR: 0.94; p = 0.020), ISI score (OR: 1.14; p = 0.002), surgery type (laparoscopic or open; OR: 0.12; p < 0.001), total power (OR: 2.02; p < 0.001), and alpha 1 (OR: 0.03; p < 0.001).ConclusionWe employed a multiple logistic regression model to determine the likelihood of moderate‐to‐severe postoperative pain upon arrival at the PACU. Physicians could personalize analgesic regimens based on a deeper comprehension of the factors that contribute to postoperative pain.
Nyctinastic movement in legumes: Developmental mechanisms, factors and biological significance
Authors: Wang Min , Zheng Shuze , Han Jingyi , Liu Yuqi , Wang Yun , Wang Weilin , Tang Ximi , Zhou Chuanen 
Published: August 2023

AbstractIn legumes, a common phenomenon known as nyctinastic movement is observed. This movement involves the horizontal expansion of leaves during the day and relative vertical closure at night. Nyctinastic movement is driven by the pulvinus, which consists of flexor and extensor motor cells. The turgor pressure difference between these two cell types generates a driving force for the bending and deformation of the pulvinus. This review focuses on the developmental mechanisms of the pulvinus, the factors affecting nyctinastic movement, and the biological significance of this phenomenon in legumes, thus providing a reference for further research on nyctinastic movement.