bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of the COVID-19 pandemic on delayed care of cardiovascular diseases in Europe: a systematic review
Authors: Khan Yasmine , Verhaeghe Nick , Devleesschauwer Brecht , Cavillot Lisa , Gadeyne Sylvie , Pauwels Nele , Van den Borre Laura , De Smedt Delphine 
Published: September 2023

Abstract

Aims
Cardiovascular diseases (CVD) are the leading cause of death worldwide. The coronavirus disease 2019 (COVID-19) pandemic has disrupted healthcare systems, causing delays in essential medical services, and potentially impacting CVD treatment. This study aims to estimate the impact of the pandemic on delayed CVD care in Europe by providing a systematic overview of the available evidence.

Methods and results
PubMed, Embase, and Web of Science were searched until mid-September 2022 for studies focused on the impact of delayed CVD care due to the pandemic in Europe among adult patients. Outcomes were changes in hospital admissions, mortality rates, delays in seeking medical help after symptom onset, delays in treatment initiation, and change in the number of treatment procedures. We included 132 studies, of which all were observational retrospective. Results were presented in five disease groups: ischaemic heart diseases (IHD), cerebrovascular accidents (CVA), cardiac arrests (CA), heart failures (HF), and others, including broader CVD groups. There were significant decreases in hospital admissions for IHD, CVA, HF and urgent and elective cardiac procedures, and significant increases for CA. Mortality rates were higher for IHD and CVA.

Conclusion
The pandemic led to reduced acute CVD hospital admissions and increased mortality rates. Delays in seeking medical help were observed, while urgent and elective cardiac procedures decreased. Adequate resource allocation, clear guidelines on how to handle care during health crises, reduced delays, and healthy lifestyle promotion should be implemented. The long-term impact of pandemics on delayed CVD care, and the health-economic impact of COVID-19 should be further evaluated.
Environmental dependence of mutational (co)variances of adaptive traits
Authors: Kannan Ashvitha , Dugand Robert J , Appleton Nicholas C , Chenoweth Stephen F , Sgrò Carla M , McGuigan Katrina 
Published: September 2023

Abstract
Standing genetic variation, and capacity to adapt to environment change, will ultimately depend on the fitness effects of mutations across the range of environments experienced by contemporary, panmictic, populations. We investigated how mild perturbations in diet and temperature affect mutational (co)variances of traits that evolve under climatic adaptation, and contribute to individual fitness in Drosophila serrata. We assessed egg-to-adult viability, development time and wing size of 64 lines that had diverged from one another via spontaneous mutation over 30 generations of brother–sister mating. Our results suggested most mutations have directionally concordant (i.e., synergistic) effects in all environments and both sexes. However, elevated mutational variance under reduced macronutrient conditions suggested environment-dependent variation in mutational effect sizes for development time. We also observed evidence for antagonistic effects under standard versus reduced macronutrient conditions, where these effects were further contingent on temperature (for development time) or sex (for size). Diet also influenced the magnitude and sign of mutational correlations between traits, although this result was largely due to a single genotype (line), which may reflect a rare, large effect mutation. Overall, our results suggest environmental heterogeneity and environment-dependency of mutational effects could contribute to the maintenance of genetic variance.
New Medical Herbalism Formulations as a Targeted Therapeutic Strategies Used in Southern Tunisia to Promote Neo-Epithelium, Angiogenesis, and Collagen Biosynthesis and to Impede Scar Formation Post-Third-Degree Burned Skin
Authors: Guesmi Fatma , Saidi Issam , Dridi Imen , Bouzenna Hafsia , Hfaiedh Najla , Ali Borgi Mohamed , Landoulsi Ahmed 
Published: September 2023

Abstract
The aim of the study is to assess the suitability of the herbal formulation for topical application as a skin burn dressing on the in vivo wound-closure of third-degree wound injuries. Rat wound models were used to prove the in vivo skin burn-healing process. Body weight gain, food and water intake, and behavior were investigated daily during treatment period. Cutaneous biopsies of the burned wound surfaces were monitored at days 4, 13, and 28. Formulation markedly (P &lt; .05) increased wound repair rate and collagen production compared to untreated burnt skin. Macroscopic and histological analysis of the wound of formula (F)-treated group showed significant skin contraction rate and rapid wound healing without scar through regeneration of epidermis that were approved in formula mixed with honey (F-hY)- and Drs-treated wound compared with thymol, and the untreated wound tissues that were not covered by denuded epithelial. Furthermore, the wound healing efficacy of F-hY, F, and Drs cream was proved by decreased the amount of malondialdehyde compared to untreated rats. In conclusion, F and F-hY was found to promote cutaneous wound repair. In all case, the formula alone or mixed with honeybees was even better than thymol in the repair of cutaneous wound.
Evaluating spotted lanternfly (Hemiptera: Fulgoridae) infestation in the Northern Ohio Valley
Authors: Vetrovec Melody , Payne Christopher J 
Published: September 2023

Abstract
Lycorma delicatula White (spotted lanternfly; SLF) is an invasive pest insect threatening increased agricultural costs as it spreads rapidly westward across the United States. As such, surveying was conducted adjacent to the insect’s westernmost quarantine area in 2021–2022 to support multi-state monitoring. Specifically, 2,077 visual and sticky-trap surveys were performed in 13 repeatedly surveyed plots strategically located near high-traffic roadways and rail-lines along the Ohio-West Virginia border. Sites were located in Jefferson (Ohio), Brooke (West Virginia), and Hancock (West Virginia) counties. Only one SLF was detected in 2021 (the third documented Ohio site containing SLF) in close proximity to a railway, consistent with rail-mediated dispersal trends recorded throughout the United States. Thirty-one SLF were captured in 2 Ohio sites in 2022, 30 of which were captured at the same railway site as in 2021. However, 1 of the 31 SLF was found in a plot on a university campus 1.25 km from the nearest railway, along with 10 additional specimens found in a follow-up visual survey of a neighboring woodlot. Failure to detect SLF at nearby survey plots nearer to the closest rail line and commuter parking lots suggests local unaided dispersal in a state with primarily train-mediated dispersal—mirroring trends in affected states with more established SLF populations. Data from this survey are valuable for establishing baselines and early-invasion patterns of SLF dispersal into Ohio, anticipating SLF expansion patterns in Ohio, and eventually contributing to improved SLF dispersal modeling in Ohio, the Midwest, and the United States.
Gastroesophageal junction adenocarcinoma 1-year after sleeve gastrectomy
Authors: Brown Kevin C , Esnaola Gabriela , Boffa Dan , Morton John M 
Published: September 2023

Abstract
Gastroesophageal malignancy after sleeve gastrectomy is rare. A 70-year-old male with a BMI of 46 underwent laparoscopic sleeve gastrectomy with normal endoscopy. By 10 months postop, the patient had reduced BMI to 30.5. Eleven months postop, he presented with emesis and endoscopy showed severe stenosis at the gastroesophageal junction with EUS showing a circumferential mass. Patient had adenocarcinoma of the distal esophagus HER 3+ and MMR proficient, clinical T2N1. He underwent esophageal stent placement followed by FOLFOX switched to carboplatin-Taxol with radiation therapy complicated by a localized perforation requiring antibiotics. After PET scan of esophageal mass indicated response, he underwent an open distal esophagectomy, total gastrectomy with Roux-en-Y esophagojejunostomy, and placement of feeding tube. Pathology revealed poorly differentiated invasive adenocarcinoma with negative margins. In the USA, this represents only the second adenocarcinoma following a sleeve gastrectomy and the first in a non-immune compromised patient.
Management of Severe Burn Wounds Colonized With Multi-resistant Pseudomonas aeruginosa and Fusarium Using Marine Omega3 Wound Matrix in a Female Victim of War
Authors: Smolle Christian , Holzer-Geissler Judith C J , Auinger Daniel , Mykoliuk Iurii , Luze Hanna , Nischwitz Sebastian P , Kamolz Lars-Peter 
Published: September 2023

ABSTRACT
War-related burns are common injuries, also among the civilian population. Additional trauma such as fractures or shrapnel wounds may add significant morbidity. Burn injuries in war zones are furthermore frequently undertreated and hence prone to complications. We report a case of a young female victim of war, whose severely infected burn wounds could be successfully healed using a combination of targeted antimicrobial therapy, wound conditioning using decellularized fish skin, and subsequent skin grafting.
Uchuu–ν2GC galaxies and AGN: cosmic variance forecasts of high-redshift AGN for JWST, Euclid, and LSST
Authors: Oogi Taira , Ishiyama Tomoaki , Prada Francisco , Sinha Manodeep , Croton Darren , Cora Sofía A , Jullo Eric , Klypin Anatoly A , Nagashima Masahiro , Cacheiro J López , Ruedas José , Kobayashi Masakazu A R , Makiya Ryu 
Published: September 2023

ABSTRACT
Measurements of the luminosity function of active galactic nuclei (AGN) at high redshift (z ≳ 6) are expected to suffer from field-to-field variance, including cosmic and Poisson variances. Future surveys, such as those from the Euclid telescope and JWST, will also be affected by field variance. We use the Uchuu simulation, a state-of-the-art cosmological N-body simulation with 2.1 trillion particles in a volume of 25.7 Gpc3, combined with a semi-analytic galaxy and AGN formation model, to generate the Uchuu–ν2GC catalogue, publicly available, that allows us to investigate the field-to-field variance of the luminosity function of AGN. With this Uchuu–ν2GC model, we quantify the cosmic variance as a function of survey area, AGN luminosity, and redshift. In general, cosmic variance decreases with increasing survey area and decreasing redshift. We find that at z ∼ 6 − 7, the cosmic variance depends weakly on AGN luminosity. This is because the typical mass of dark matter haloes in which AGN reside does not significantly depend on luminosity. Due to the rarity of AGN, Poisson variance dominates the total field-to-field variance, especially for bright AGN. We also examine the effect of parameters related to galaxy formation physics on the field variance. We discuss uncertainties present in the estimation of the faint-end of the AGN luminosity function from recent observations, and extend this to make predictions for the expected number of AGN and their variance for upcoming observations with Euclid, JWST, and the Legacy Survey of Space and Time (LSST).
Statistical analysis of stochastic magnetic fluctuations in space plasma based on theMMSmission
Authors: Macek Wiesław M , Wójcik Dariusz 
Published: September 2023

ABSTRACTBased on the Magnetospheric Multiscale (MMS) mission we look at magnetic field fluctuations in the Earth’s magnetosheath. We apply the statistical analysis using a Fokker–Planck equation to investigate processes responsible for stochastic fluctuations in space plasmas. As already known, turbulence in the inertial range of hydromagnetic scales exhibits Markovian features. We have extended the statistical approach to much smaller scales in space, where kinetic theory should be applied. Here we study in detail and compare the characteristics of magnetic fluctuations behind the bow shock, inside the magnetosheath, and near the magnetopause. It appears that the first Kramers–Moyal coefficient is linear and the second term is a quadratic function of magnetic increments, which describe drift and diffusion, correspondingly, in the entire magnetosheath. This should correspond to a generalization of Ornstein–Uhlenbeck process. We demonstrate that the second-order approximation of the Fokker–Planck equation leads to non-Gaussian kappa distributions of the probability density functions. In all cases in the magnetosheath, the approximate power-law distributions are recovered. For some moderate scales, we have the kappa distributions described by various peaked shapes with heavy tails. In particular, for large values of the kappa parameter this shape is reduced to the normal Gaussian distribution. It is worth noting that for smaller kinetic scales the rescaled distributions exhibit a universal global scale invariance, consistently with the stationary solution of the Fokker–Planck equation. These results, especially on kinetic scales, could be important for a better understanding of the physical mechanism governing turbulent systems in space and astrophysical plasmas.
Lowest accreting protoplanetary discs consistent with X-ray photoevaporation driving their final dispersal
Authors: Ercolano Barbara , Picogna Giovanni , Monsch Kristina 
Published: September 2023

ABSTRACT
Photoevaporation from high-energy stellar radiation has been thought to drive the dispersal of protoplanetary discs. Different theoretical models have been proposed, but their predictions diverge in terms of the rate and modality at which discs lose their mass, with significant implications for the formation and evolution of planets. In this paper, we use disc population synthesis models to interpret recent observations of the lowest accreting protoplanetary discs, comparing predictions from EUV-driven, FUV-driven, and X-ray-driven photoevaporation models. We show that the recent observational data of stars with low accretion rates (low accretors) point to X-ray photoevaporation as the preferred mechanism driving the final stages of protoplanetary disc dispersal. We also show that the distribution of accretion rates predicted by the X-ray photoevaporation model is consistent with observations, while other dispersal models tested here are clearly ruled out.
Chromene-based BioAIEgens: ‘in-water’ synthesis, regiostructure-dependent fluorescence and ER-specific imaging
Authors: Cai Xu-Min , Lin Yuting , Zhang Jianyu , Li Ying , Tang Zhenguo , Zhang Xuedan , Jia Ying , Wang Wenjin , Huang Shenlin , Alam Parvej , Zhao Zheng , Tang Ben Zhong 
Published: September 2023

Abstract
Exploration of artificial aggregation-induced emission luminogens (AIEgens) has garnered extensive interest in the past two decades. In particular, AIEgens possessing natural characteristics (BioAIEgens) have received more attention recently due to the advantages of biocompatibility, sustainability and renewability. However, the extremely limited number of BioAIEgens extracted from natural sources have retarded their development. Herein, a new class of BioAIEgens based on the natural scaffold of chromene have been facilely synthesized via green reactions in a water system. These compounds show regiostructure-, polymorphism- and substituent-dependent fluorescence, which clearly illustrates the close relationship between the macroscopic properties and hierarchical structure of aggregates. Due to the superior biocompatibility of the natural scaffold, chromene-based BioAIEgens can specifically target the endoplasmic reticulum (ER) via the introduction of tosyl amide. This work has provided a new chromene scaffold for functional BioAIEgens on the basis of green and sustainable ‘in-water’ synthesis, applicable regiostructure-dependent fluorescence, and effective ER-specific imaging.
Evaluation of the Geographical Accessibility of Genome-Matched Clinical Trials on a National Experience
Authors: Crimini Edoardo , Tini Giulia , Tarantino Paolo , Ascione Liliana , Repetto Matteo , Beria Paolo , Ranghiero Alberto , Marra Antonio , Belli Carmen , Criscitiello Carmen , Esposito Angela , Guerini Rocco Elena , Barberis Massimo C P , Mazzarella Luca , Curigliano Giuseppe 
Published: September 2023

Abstract

Background
Molecular-driven oncology allows oncologists to identify treatments that match a cancer’s genomic profile. Clinical trials are promoted as an effective modality to deliver a molecularly matched treatment. We explore the role of geographical accessibility in Italy, and its impact on patient access to clinical trials.

Material and Methods
We retrospectively reviewed molecular data from a single-institutional case series of patients receiving next-generation sequencing testing between March 2019 and July 2020. Actionable alterations were defined as the ones with at least one matched treatment on Clinicaltrials.gov at the time of genomic report signature. We then calculated the hypothetical distance to travel to reach the nearest assigned clinical trial.

Results
We identified 159 patients eligible for analysis. One hundred and one could be potentially assigned to a clinical trial in Italy, and the median distance that patients needed to travel to reach the closest location with a suitable clinical trial was 76 km (interquartile range = 127.46 km). Geographical distribution of clinical trials in Italy found to be heterogeneous, with Milan and Naples being the areas with a higher concentration. We then found that the probability of having a clinical trial close to a patient’s hometown increased over time, according to registered studies between 2015 and 2020.

Conclusions
The median distance to be travelled to the nearest trial was generally acceptable for patients, and trials availability is increasing. Nevertheless, many areas are still lacking trials, so efforts are required to increase and homogenize the possibilities to be enrolled in clinical trials for Italian patients with cancer.
Random Forest for Predicting Treatment Response to Radioiodine and Thyrotropin Suppression Therapy in Patients With Differentiated Thyroid Cancer But Without Structural Disease
Authors: Sa Ri , Yang Taiyu , Zhang Zexu , Guan Feng 
Published: September 2023

Abstract

Background
We aimed to develop a machine-learning model for predicting treatment response to radioiodine (131I) therapy and thyrotropin (TSH) suppression therapy in patients with differentiated thyroid cancer (DTC) but without structural disease, based on pre-treatment information.

Patients and Methods
Overall, 597 and 326 patients with DTC but without structural disease were randomly assigned to “training” cohorts for predicting treatment response to 131I therapy and TSH suppression therapy, respectively. Six supervised algorithms, including Logistic Regression, Support Vector Machine, Random Forest (RF), Neural Networks, Adaptive Boosting, and Gradient Boost, were used to predict effective response (ER) to 131I therapy and biochemical remission (BR) to TSH suppression therapy.

Results
Stimulated and suppressed thyroglobulin (Tg) and radioiodine uptake before the current course of 131I therapy were mostly attributed to ER to 131I therapy, while thyroid remnant available on the post-therapeutic whole-body scan at the last course of 131I therapy and TSH were greatly contributed to Tg decline under TSH suppression therapy. RF showed the best performance among all models. The accuracy and area under the receiver operating characteristic curve (AUC) for segregating ER from non-ER during 131I therapy with RF were 81.3% and 0.896, respectively. The accuracy and AUC for predicting BR to TSH suppression therapy with RF were 78.7% and 0.857, respectively.

Conclusion
This study demonstrates that machine learning models, especially the RF algorithm are useful tools that may predict treatment response to 131I therapy and TSH suppression therapy in DTC patients without structural disease based on pre-treatment routine clinical variables and biochemical markers.
Appropriateness of premature ovarian insufficiency recommendations provided by ChatGPT
Authors: Sütcüoğlu Bengü Mutlu , Güler Melike 
Published: September 2023

Abstract

Objective
This study aimed to evaluate the appropriateness of ChatGPT's responses to frequently asked queries regarding the prevention and treatment of premature ovarian insufficiency (POI).

Methods
A set of 25 questions covering topics related to disease risk factors, screening, symptoms, treatment, and treatment adverse effects were posed to ChatGPT, and the responses were evaluated by two experienced obstetrician/gynecologists.

Results
Of the responses given by ChatGPT, 19 of 25 (76%) were deemed appropriate, five (20%) were rated as inappropriate, and the remaining one (4%) was considered unreliable. There was no question that ChatGPT answered completely incorrectly; answers that were considered inappropriate included partially correct information.

Conclusions
The study's findings suggest that ChatGPT provides patients with mostly accurate information about the POI but might present significantly inaccurate information. However, it is important to note that further research is needed to validate the use of artificial intelligence chatbots in the context of reproductive health, especially for individuals who may be highly impacted by the emotional and psychological effects of POI. In addition, given the complexity and individuality of medical care, AI chatbots should not be considered a replacement for medical professionals but rather a supplementary tool that can help patients access reliable information and support. Overall, this study contributes to the growing body of research on AI chatbots and their potential use in reproductive health, highlighting both the benefits and limitations of these technologies.
Coronary microvascular dysfunction and heart failure with preserved ejection fraction: what are the mechanistic links?
Authors: Sinha Aish , Rahman Haseeb , Perera Divaka 
Published: September 2023

Purpose of review
Heart failure with preserved ejection fraction (HFpEF) accounts for half of all heart failure presentations and is associated with a dismal prognosis. HFpEF is an umbrella term that constitutes several distinct pathophysiological entities. Coronary microvascular dysfunction (CMD), defined as the inability of the coronary vasculature to augment blood flow adequately in the absence of epicardial coronary artery disease, is highly prevalent amongst the HFpEF population and likely represents one distinct HFpEF endotype, the CMD-HFpEF endotype. This review appraises recent studies that have demonstrated an association between CMD and HFpEF with an aim to understand the pathophysiological links between the two. This is of significant clinical relevance as better understanding of the pathophysiology underlying CMD-HFpEF may result in more targeted and efficacious therapeutic options in this patient cohort.

Recent findings
There is a high prevalence of CMD, diagnosed invasively or noninvasively, in patients with HFpEF. Patients with HFpEF who have an impaired myocardial perfusion reserve (MPR) have a worse outcome than those with a normal MPR. Both MPR and coronary flow reserve (CFR) are associated with measures of left ventricular diastolic function and left ventricular filling pressures during exercise. Impaired lusitropy and subendocardial ischaemia link CMD and HFpEF mechanistically.

Summary
CMD-HFpEF is a prevalent endotype of HFpEF and one that is associated with adverse cardiovascular prognosis. Whether CMD leads to HFpEF, through subendocardial ischaemia, or whether it is secondary to the impaired lusitropy that is characteristic of HFpEF is not known. Further mechanistic work is needed to answer this pertinent question.