bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between changes in loop diuretic dose and outcomes in acute heart failure
Authors: Seko Yuta , Kato Takao , Morimoto Takeshi , Yaku Hidenori , Inuzuka Yasutaka , Tamaki Yodo , Ozasa Neiko , Shiba Masayuki , Yamamoto Erika , Yoshikawa Yusuke , Yamashita Yugo , Kitai Takeshi , Taniguchi Ryoji , Iguchi Moritake , Nagao Kazuya , Kawai Takafumi , Komasa Akihiro , Nishikawa Ryusuke , Kawase Yuichi , Morinaga Takashi , Toyofuku Mamoru , Furukawa Yutaka , Ando Kenji , Kadota Kazushige , Sato Yukihito , Kuwahara Koichiro , Kimura Takeshi ,   for the KCHF Study Investigators
Published: March 2023

AbstractAimsLittle is known about the association between the starting of or dose changes in loop diuretics during acute heart failure (AHF) hospitalization and post‐discharge outcomes. We investigated the clinical impact of starting loop diuretics and changing the loop diuretics dose during hospitalization on post‐discharge outcomes.Methods and resultsFrom the Kyoto Congestive Heart Failure registry, 3665 consecutive patients hospitalized for HF and discharged alive were included in this study. We analysed 1906 patients without loop diuretics on admission and were discharged alive and 1759 patients who received loop diuretics on admission and were discharged alive. The primary outcome measure was all‐cause death. Of the 1906 patients without loop diuretics on admission, 1366 (71.7%) patients started loop diuretics during the index AHF hospitalization. Starting loop diuretics was not associated with lower post‐discharge mortality [adjusted hazard ratio (HR) 0.92, 95% confidence interval (CI) 0.68–1.25]. Of the 1759 patients who received loop diuretics on admission, loop diuretic dose was decreased in 23.8%, unchanged in 44.6%, and increased in 31.6% of the patients. Changes in the dose at discharge compared with no change in dose were not associated with lower risk of post‐discharge mortality (decrease relative to no change: adjusted HR 0.98, 95% CI 0.76–1.28; increase relative to no change: adjusted HR 1.00, 95% CI 0.78–1.27). Compared with no loop diuretics at discharge, a loop diuretics dose of ≥80 mg at discharge was associated with higher post‐discharge mortality risk.ConclusionsIn patients with AHF, we found no association between the starting of loop diuretics and post‐discharge outcomes and between dose changes and post‐discharge outcomes.
Recent advances on the development of graphene‐based field‐effect transistors, electrochemical biosensors and electrochemiluminescence biosensors
Authors: Hu Xue‐Bo , Zhang Yi‐Xiao , Chen Xiao‐Hui , He Meng‐Yuan , Jin Zi‐He 
Published: March 2023

AbstractGraphene, a honeycomb lattice of carbon material with single‐atom‐layer structure, demonstrates extraordinary mechanical, thermal, chemical and electronic properties. Thus, it has sparked tremendous interests in various fields, such as energy storage and conversion devices, field‐effect transistors (FET), chemical sensors and biosensors. In this review, we will first focus on the synthesis method of graphene and the fabrication strategy of graphene‐based materials. Subsequently, the construction of graphene‐based biosensors are introduced, in which three kinds of biosensors are discussed in details, including the FET, electrochemical biosensors and electrochemiluminescence (ECL) biosensors. The performances of the state‐of‐the‐art biosensors on the detection of biomolecules are also displayed. Finally, we also highlight some critical challenges remain to be solved and the development in this field for further research.
In the fast lane: Receptor trafficking during status epilepticus
Authors: Naylor David E. 
Published: March 2023

AbstractStatus epilepticus (SE) remains a significant cause of morbidity and mortality and often is refractory to standard first‐line treatments. A rapid loss of synaptic inhibition and development of pharmacoresistance to benzodiazepines (BZDs) occurs early during SE, while NMDA and AMPA receptor antagonists remain effective treatments after BZDs have failed. Multimodal and subunit‐selective receptor trafficking within minutes to an hour of SE involves GABA‐A, NMDA, and AMPA receptors and contributes to shifts in the number and subunit composition of surface receptors with differential impacts on the physiology, pharmacology, and strength of GABAergic and glutamatergic currents at synaptic and extrasynaptic sites. During the first hour of SE, synaptic GABA‐A receptors containing γ2 subunits move to the cell interior while extrasynaptic GABA‐A receptors with δ subunits are preserved. Conversely, NMDA receptors containing N2B subunits are increased at synaptic and extrasynaptic sites, and homomeric GluA1 (“GluA2‐lacking”) calcium permeant AMPA receptor surface expression also is increased. Molecular mechanisms, largely driven by NMDA receptor or calcium permeant AMPA receptor activation early during circuit hyperactivity, regulate subunit‐specific interactions with proteins involved with synaptic scaffolding, adaptin‐AP2/clathrin‐dependent endocytosis, endoplasmic reticulum (ER) retention, and endosomal recycling. Reviewed here is how SE‐induced shifts in receptor subunit composition and surface representation increase the excitatory to inhibitory imbalance that sustains seizures and fuels excitotoxicity contributing to chronic sequela such as “spontaneous recurrent seizures” (SRS). A role for early multimodal therapy is suggested both for treatment of SE and for prevention of long‐term comorbidities.
Potential Risk of Residues From Neonicotinoid-Treated Sugar Beet in Flowering Weeds to Honey Bees (Apis mellifera L.)
Authors: Odemer Richard , Friedrich Elsa , Illies Ingrid , Berg Stefan , Pistorius Jens , Bischoff Gabriela 
Published: March 2023

Abstract
In 2018 the European Union (EU) banned the three neonicotinoid insecticides imidacloprid, clothianidin (CLO), and thiamethoxam (TMX), but they can still be used if an EU Member State issues an emergency approval. Such an approval went into effect in 2021 for TMX-coated sugar beet seeds in Germany. Usually, this crop is harvested before flowering without exposing non-target organisms to the active ingredient or its metabolites. In addition to the approval, strict mitigation measures were imposed by the EU and the German federal states. One of the measures was to monitor the drilling of sugar beet and its impact on the environment. Hence we took residue samples from different bee and plant matrices and at different dates to fully map beet growth in the German states of Lower Saxony, Bavaria, and Baden-Württemberg. A total of four treated and three untreated plots were surveyed, resulting in 189 samples. Residue data were evaluated using the US Environmental Protection Agency BeeREX model to assess acute and chronic risk to honey bees from the samples, because oral toxicity data are widely available for both TMX and CLO. Within treated plots, we found no residues either in pools of nectar and honey crop samples (n = 24) or dead bee samples (n = 21). Although 13% of beebread and pollen samples and 88% of weed and sugar beet shoot samples were positive, the BeeREX model found no evidence of acute or chronic risk. We also detected neonicotinoid residues in the nesting material of the solitary bee Osmia bicornis, probably from contaminated soil of a treated plot. All control plots were free of residues. Currently, there are insufficient data on wild bee species to allow for an individual risk assessment. In terms of the future use of these highly potent insecticides, therefore, it must be ensured that all regulatory requirements are complied with to mitigate any unintentional exposure. Environ Toxicol Chem 2023;42:1167–1177. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Combination of four bacterial strains isolated from Yamahai‐shubo in traditional Japanese sake brewing
Authors: Fujiwara Hisashi , Watanabe Kunihiko , Wakai Yoshinori 
Published: March 2023

AbstractThis study investigated the interactions of four bacteria strains isolated from Yamahai‐shubo, the source of yeast used to produce a Japanese traditional rice wine, Yamahai‐shikomi sake. The bacterial strains were nitrate‐reducing Pseudomonas sp. 61‐02, Leuconostoc mesenteroides LM‐1, Lactiplantibacillus plantarum LP‐2, and Latilactobacillus sakei LS‐4. We examined fermentation factors for Yamahai‐shubo and Yamahai‐shikomi sake samples to compare the suitability of their bacterial combination (16 variations). As a result of principal component analysis, we found that two major groups were formed; one containing strain LP‐2 and the other containing strain LS‐4, and that strains LP‐2 and LS‐4 were important in the Yamahai‐shikomi sake in the presence of strains 61‐02 and LM‐1. Then, we investigated the effects of strains LP‐2 and LS‐4 on the concentration of organic acids (pyruvic acid, citric acid, succinic acid, malic acid, and lactic acid) in Yamahai‐shikomi sake. Only in lactic acid, a tendency to decrease with a smaller proportion of LS‐4 strains in Yamahai‐shubo was observed. Subsequently, their effect on the concentration of diacetyl, crucial for aroma, was investigated between the LP‐2 and LS‐4 strains. The sample prepared in the absence of strain LS‐4 exhibited the lowest concentration of diacetyl. This result was supported by the statistical analysis for the sensory scores performed for aroma of each Yamahai‐shikomi sake sample. In conclusion, strain LP‐2 plays a more significant role in improving Yamahai‐shikomi sake quality with strains LM‐1 and 61‐02 rather than strain LS‐4 in Yamahai‐shubo preparation and Yamahai‐shikomi sake brewing.
A neuropsychological profile and its correlation with neuroimaging markers in patients with subcortical ischaemic vascular dementia
Authors: Tian Rui , Zhang Yanxin , Liu Fang , Xue Xinran , Zhang Yutong , Tian Zhuo , Fang Tingting , Fan Ruxue , Li Yuan , Zhang Nan 
Published: March 2023

AbstractObjectivesCognitive and neuroimaging assessments are still the main clinical practice methods for screening and diagnosing vascular dementia (VaD) patients. This study aimed to establish the neuropsychological characteristics of mild‐to‐moderate subcortical ischaemic vascular dementia (SIVD) patients, find an optimal cognitive marker for differentiating them from Alzheimer's disease (AD) patients, and explore the correlation between cognitive function and total small vessel disease (SVD) burden.MethodsSIVD (n = 60) and AD (n = 30) patients and cognitively unimpaired healthy controls (HCs; n = 30) were recruited from our longitudinal MRI AD and SIVD study (ChiCTR1900027943) and received a comprehensive neuropsychological assessment and a multimodal MRI scan. Cognitive performance and MRI SVD markers were compared between groups. Combined cognitive scores were established for differentiating between SIVD and AD patients. Correlations between cognitive function and total SVD scores were analysed in dementia patients.ResultsSIVD patients showed poorer performance in information processing speed and better performance in memory, language, and visuospatial function than AD patients, although all cognitive domains were impaired in both groups compared with HCs. Combined cognitive scores showed an area under the curve of 0.727 (95%CI 0.62–0.84, p < 0.001) for differentiating SIVD and AD patients. Auditory Verbal Learning Test recognition scores were negatively correlated with total SVD scores in SIVD patients.ConclusionsOur results suggested that neuropsychological assessments, specifically combined tests including episodic memory, information processing speed, language and visuospatial ability, are useful in the clinical differentiation between SIVD and AD patients. Moreover, cognitive dysfunction was partly correlated with MRI SVD burden in SIVD patients.
Gated transformations from egocentric to allocentric reference frames involving retrosplenial cortex, entorhinal cortex, and hippocampus
Authors: Alexander Andrew S. , Robinson Jennifer C. , Stern Chantal E. , Hasselmo Michael E. 
Published: March 2023

AbstractThis paper reviews the recent experimental finding that neurons in behaving rodents show egocentric coding of the environment in a number of structures associated with the hippocampus. Many animals generating behavior on the basis of sensory input must deal with the transformation of coordinates from the egocentric position of sensory input relative to the animal, into an allocentric framework concerning the position of multiple goals and objects relative to each other in the environment. Neurons in retrosplenial cortex show egocentric coding of the position of boundaries in relation to an animal. These neuronal responses are discussed in relation to existing models of the transformation from egocentric to allocentric coordinates using gain fields and a new model proposing transformations of phase coding that differ from current models. The same type of transformations could allow hierarchical representations of complex scenes. The responses in rodents are also discussed in comparison to work on coordinate transformations in humans and non‐human primates.
Does medical insurance improve health? An empirical analysis from China
Authors: Yi Chengzhi , Wei Linsha , Long Cuihong 
Published: March 2023

AbstractBackgroundMedical insurance is considered to be closely related to individual health status, while their relationship are left to be clarified. This article aims to examine the relationship between medical insurance and the health status of residents in China.MethodsThe data is from a nationally representative sample of CGSS2015, and the estimation methods of ordered logit model, generalised ordered logit model and instrumental variable (IV) were used.ResultsBoth public medical insurance (PMI) and commercial medical insurance (CMI) had a positive correlation with residents' self‐assessed physical and mental health, while PMI was more statistically significant and substantively important than CMI. The basic results estimated with the generalised ordered logit model and IV model still remained robust. Further analysis found that medical insurance, whether public or commercial, had more or less weakened the importance of income to personal health, showing a substitute effect for income.ConclusionPMI has been proven to help promote the physical and mental health of residents and moderate the importance of residents' income to health. Besides, CMI also plays a beneficial supplementary role in promoting residents' health.
TFEB‐translocated and ‐amplified renal cell carcinoma with VEGFA co‐amplification: A case of long‐term control by multimodal therapy including a vascular endothelial growth factor‐receptor inhibitor
Authors: Takamori Hajime , Maeshima Akiko Miyagi , Kato Ikuma , Baba Masaya , Nakamura Eijiro , Matsui Yoshiyuki 
Published: March 2023

IntroductionRenal cell carcinoma with TFEB amplification is rare and reportedly aggressive. We herein report a case of renal cell carcinoma with TFEB translocation and amplification in which long‐term control was achieved by multimodal therapy including a vascular endothelial growth factor ‐receptor inhibitor.Case presentationA 70‐year‐old man was referred to our institution for the treatment of renal cell carcinoma with multinodal metastases. Open nephrectomy and lymph node dissection were performed. Immunohistochemistry for transcription factor EB was positive, and fluorescent in situ hybridization revealed TFEB rearrangement and amplification. The diagnosis was TFEB‐translocated and ‐amplified renal cell carcinoma. VEGFA amplification was also demonstrated by fluorescent in situ hybridization. The residual and recurrent tumors were treated and controlled for 52 months by vascular endothelial growth factor‐receptor target therapy, radiation therapy, and additional surgery.ConclusionA good long‐term response to anti‐vascular endothelial growth factor drug therapy may be due to VEGFA amplification and subsequent vascular endothelial growth factor overexpression.
Local officials' political capital and poverty alleviation
Authors: Wang Shubin , Li Qiang , Gu Yan 
Published: March 2023

AbstractThis study examined the effect of local officials' political capital on poverty alleviation by using a manually compiled database of county party secretaries (CPSs) in impoverished counties in China. The empirical results reveal that CPSs with political capital positively affect poverty alleviation. Mechanism tests indicated that CPSs with political capital contribute to greater agricultural and financial development, attract more enterprise investment, and increase fiscal expenditure. The promotional effect of local officials' political capital on poverty alleviation was influenced by CPSs' characteristics (e.g., tenure, education level, and age) and was less pronounced during central government inspection and when the provincial government was less concerned about local officials' poverty alleviation. Our results suggest that local officials' political capital can alleviate poverty in emerging economies.
Label‐free cleared tissue microscopy and machine learning for 3D histopathology of biomaterial implants
Authors: Ngo Tran B , DeStefano Sabrina , Liu Jiamin , Su Yijun , Shroff Hari , Vishwasrao Harshad D , Sadtler Kaitlyn 
Published: March 2023

AbstractTissue clearing of whole intact organs has enhanced imaging by enabling the exploration of tissue structure at a subcellular level in three‐dimensional space. Although clearing and imaging of the whole organ have been used to study tissue biology, the microenvironment in which cells evolve to adapt to biomaterial implants or allografts in the body is poorly understood. Obtaining high‐resolution information from complex cell–biomaterial interactions with volumetric landscapes represents a key challenge in the fields of biomaterials and regenerative medicine. To provide a new approach to examine how tissue responds to biomaterial implants, we apply cleared tissue light‐sheet microscopy and three‐dimensional reconstruction to utilize the wealth of autofluorescence information for visualizing and contrasting anatomical structures. This study demonstrates the adaptability of the clearing and imaging technique to provide sub‐cellular resolution (0.6 μm isotropic) 3D maps of various tissue types, using samples from fully intact peritoneal organs to volumetric muscle loss injury specimens. Specifically, in the volumetric muscle loss injury model, we provide 3D visualization of the implanted extracellular matrix biomaterial in the wound bed of the quadricep muscle groups and further apply computational‐driven image classification to analyze the autofluorescence spectrum at multiple emission wavelengths to categorize tissue types at the injured site interacting with the biomaterial scaffolds.
Early evidence of the effect of ASU 2017‐12 on derivative disclosure compliance
Authors: Troyer Joseph , Johnston Joseph , Trimble Madeline 
Published: March 2023

AbstractThe growth in the use of financial derivatives for a variety of purposes has caused increased complexity in derivative reporting standards. As such, financial statement users have asked the Financial Accounting Standards Board to update guidance to increase transparency while preparers seek clearer guidance on the application of standards and a broadened scope of hedge accounting. The most recent derivative accounting guidance update, ASU 2017‐12 (Topic 815), broadens instruments that qualify for hedge accounting, expands allowable hedge accounting techniques, and reduces reporting requirements by omitting the reporting of hedge ineffectiveness. While these changes might simplify reporting requirements, there is the risk that the omitted disclosure would have been relevant to investors’ decision‐making. In this paper, we examine how derivative disclosure practices changed following the implementation of ASU 2017‐12. Using a hand‐collected sample of twenty S&P 500 firms, we calculate a derivative disclosure compliance (DDC) score and find that, on average, DDC scores decreased following firm adoption of ASU 2017‐12. This decline was realized for firms regardless of the notional amounts of derivative instruments held. However, the decline was not significant for early adopting firms suggesting a motivation for completeness by select firms. Our initial findings indicate that the update on derivative disclosures is not being uniformly applied potentially lessening its value to users. As a result, further updates may be necessary.
Associations between positive memory count and hazardous substance use in a trauma‐exposed sample: Examining the moderating role of emotion dysregulation
Authors: Compton Sidonia E. , Slavish Danica C. , Weiss Nicole H. , Bowen Holly J. , Contractor Ateka A. 
Published: March 2023

AbstractObjectivesResearch has demonstrated links between autobiographical memory retrieval and hazardous substance use. However, limited work has examined relations between positive autobiographical memories and hazardous substance use, as well as moderating factors influencing these relations. Thus, we examined the potential moderating roles of negative and positive emotion dysregulation in the relations between count of retrieved positive memories and hazardous substance use (alcohol and drug use separately).MethodsParticipants were 333 trauma‐exposed students (Mage = 21.05; 85.9% women) who completed self‐report measures assessing positive memory count, hazardous alcohol and drug use, negative emotion dysregulation, and positive emotion dysregulation.ResultsPositive emotion dysregulation significantly moderated the association between positive memory count and hazardous alcohol use (b = 0.04, 95% confidence interval [CI] [0.01, 0.06], p = 0.019), as well as the association between positive memory count and hazardous drug use (b = 0.02, 95% CI [0.01, 0.03], p = 0.002). Individuals with more positive emotion dysregulation had stronger associations between increases in positive memory count and increased hazardous substance use.ConclusionFindings indicate that trauma‐exposed individuals who retrieve more positive memories and experience difficulties regulating positive emotions report greater hazardous substance use. Positive emotion dysregulation may be an important target for memory‐based interventions among trauma‐exposed individuals who report hazardous substance use.