bluuebunny/crossref_metadata_2025_split huggingface dataset:
A direct comparison of sound and vibration as sources of stimulation for a sensory substitution glove
Authors: de Paz Carlos , Travieso David 
Published: July 2023

AbstractSensory substitution devices (SSDs) facilitate the detection of environmental information through enhancement of touch and/or hearing capabilities. Research has demonstrated that several tasks can be successfully completed using acoustic, vibrotactile, and multimodal devices. The suitability of a substituting modality is also mediated by the type of information required to perform the specific task. The present study tested the adequacy of touch and hearing in a grasping task by utilizing a sensory substitution glove. The substituting modalities inform, through increases in stimulation intensity, about the distance between the fingers and the objects. A psychophysical experiment of magnitude estimation was conducted. Forty blindfolded sighted participants discriminated equivalently the intensity of both vibrotactile and acoustic stimulation, although they experienced some difficulty with the more intense stimuli. Additionally, a grasping task involving cylindrical objects of varying diameters, distances and orientations was performed. Thirty blindfolded sighted participants were divided into vibration, sound, or multimodal groups. High performance was achieved (84% correct grasps) with equivalent success rate between groups. Movement variables showed more precision and confidence in the multimodal condition. Through a questionnaire, the multimodal group indicated their preference for using a multimodal SSD in daily life and identified vibration as their primary source of stimulation. These results demonstrate that there is an improvement in performance with specific-purpose SSDs, when the necessary information for a task is identified and coupled with the delivered stimulation. Furthermore, the results suggest that it is possible to achieve functional equivalence between substituting modalities when these previous steps are met.
Establishing clinically meaningful within-individual improvement thresholds for eight patient-reported outcome measures in people with relapsing-remitting multiple sclerosis
Authors: Greene Nupur , Quéré Stéphane , Bury Denise P. , Mazerolle Flora , M’Hari Manal , Loubert Angély , Regnault Antoine , Higuchi Keiko 
Published: July 2023

Abstract
Background
As disease-modifying therapies do not reverse the course of multiple sclerosis (MS), assessment of therapeutic success involves documenting patient-reported outcomes (PROs) concerning health-related quality of life, disease and treatment-related symptoms, and the impact of symptoms on function. Interpreting PRO data involves going beyond statistical significance to calculate within-patient meaningful change scores. These thresholds are needed for each PRO in order to fully interpret the PRO data. This analysis of PRO data from the PROMiS AUBAGIO study, which utilized 8 PRO instruments in teriflunomide-treated relapsing-remitting MS (RRMS) patients, was designed to estimate clinically meaningful within-individual improvement thresholds in the same manner, for 8 PRO instruments.

Results
The analytical approach followed a triangulation exercise that considered results from anchor- and distribution-based methods and graphical representations of empirical cumulative distribution functions in PRO scores in groups defined by anchor variables. Data from 8 PRO instruments (MSIS-29 v2, FSMC, MSPS, MSNQ, TSQM v1.4, PDDS, HRPQ-MS v2, and HADS) were assessed from 434 RRMS patients. For MSIS-29 v2, FSMC, MSPS, and MSNQ total scores, available anchor variables enabled both anchor- and distribution-based methods to be applied. For instruments with no appropriate anchor available, distribution-based methods were applied. A recommended value for meaningful within-individual improvement was defined by comparing mean change in PRO scores between participants showing improvement of one or two categories in the anchor variable or those showing no change. A “lower bound” estimate was calculated using distribution-based methods. An improvement greater than the lower-bound estimate was considered “clinically meaningful”.

Conclusion
This analysis produced estimates for assessing meaningful within-individual improvements for 8 PRO instruments used in MS studies. These estimates should be useful for interpreting scores and communicating study results and should facilitate decision-making by regulatory and healthcare authorities where these 8 PROs are commonly employed.
Structure, extraction, processing, and applications of collagen as an ideal component for biomaterials - a review
Authors: Chen Qijue , Pei Ying , Tang Keyong , Albu-Kaya Mǎdǎlina Georgiana 
Published: July 2023

AbstractCollagen with a multi-hierarchical architecture exhibits powerful biological performance, thus being developed in biomedical applications as a processing building block. The isolated collagen after extraction from biological tissues can be processed into various forms such as fibrils, scaffolds, membranes, microspheres, hydrogels, and sponges for further use in specific applications. This review briefly discusses the multi-hierarchical structure, powerful biological performances, extraction, and processing approaches of collagen as a natural biomaterial. The processing of collagen including dissolution, self-assembly, cross-linking, and electrospinning, is discussed to show more feasibility for specific applications of collagen composite biomaterials. Further emphasis is directed towards the biomedical applications of drug and gene delivery, as well as tissue repair involving bone, cartilage, vascular, and corneal, along with wound healing. Additionally, there is a focus on the development of flexible sensors and electronic skins (e-skins). Furthermore, the potential challenges and perspectives for the development of collagen-based biomaterials are proposed. In short, collagen-based biomaterials are expected to facilitate sustainable development and the next generation of advanced biomaterial applications.Graphical Abstract
A role for artificial intelligence applications inside and outside of the operating theatre: a review of contemporary use associated with total knee arthroplasty
Authors: Kurmis Andrew P. 
Published: July 2023

AbstractBackgroundArtificial intelligence (AI) has become involved in many aspects of everyday life, from voice-activated virtual assistants built into smartphones to global online search engines. Similarly, many areas of modern medicine have found ways to incorporate such technologies into mainstream practice. Despite the enthusiasm, robust evidence to support the utility of AI in contemporary total knee arthroplasty (TKA) remains limited. The purpose of this review was to provide an up-to-date summary of the use of AI in TKA and to explore its current and future value.MethodsInitially, a structured systematic review of the literature was carried out, following PRISMA search principles, with the aim of summarising the understanding of the field and identifying clinical and knowledge gaps.ResultsA limited body of published work exists in this area. Much of the available literature is of poor methodological quality and many published studies could be best described as “demonstration of concepts” rather than “proof of concepts”. There exists almost no independent validation of reported findings away from designer/host sites, and the extrapolation of key results to general orthopaedic sites is limited.ConclusionWhile AI has certainly shown value in a small number of specific TKA-associated applications, the majority to date have focused on risk, cost and outcome prediction, rather than surgical care, per se. Extensive future work is needed to demonstrate external validity and reliability in non-designer settings. Well-performed studies are warranted to ensure that the scientific evidence base supporting the use of AI in knee arthroplasty matches the global hype.
Unripe banana and defatted sesame seed flours improve nutritional profile, dietary fibre and functional properties of gluten-free sorghum cookies
Authors: Ayo-Omogie Helen Nwakego 
Published: July 2023

AbstractRising incidence of nutritional deficiency and chronic diseases among celiacs continuously drives the food industry to search for novel functional ingredients high in health-promoting constituents such as dietary fibre and protein. This study investigated the impact of unripe banana flour and sesame meal addition as functional ingredients to enhance the dietary fibre, nutritional profile and functional properties of gluten-free sorghum cookies. Gluten-free sorghum cookies were prepared using composite sorghum flours (SF) formulated by alternately replacing SF (30–65%) with unripe Cardaba banana flour (CBF) (30–65%) and sesame meal (SM) (5%). Nutritional composition, mineral molar ratios, dietary fibre and functional properties of the flours and cookies were assessed using standard methods. Physical parameters including diameter, thickness, spread ratio and weights as well as the sensory attributes of the cookies were evaluated. While sesame meal addition significantly (p ≤ 0.05) influenced protein enhancement, CBF inclusion significantly enhanced ash, insoluble dietary fibre, mineral contents and functional properties of sorghum flours and cookies. The significantly (p ≤ 0.05) higher values in thickness, diameter and spread ratio composite cookies containing higher CBF [CBC65 (cookie with 65% CBF) had the highest values] may indicate CBF addition enhanced the cookie-making potential of sorghum flour. Similarly, its highest flavor, aftertaste and overall acceptability scores as compared to the control (100% wheat cookie) or other composite cookies may have been influenced by the combined sweetness of banana’s natural flavor and sugars produced during baking. The incorporation of Cardaba banana flour into sorghum cookie formulation may hold interesting potential as a rich source of dietary fibre and other bioactive compounds as well as aiding functional and sensory enhancement of sorghum flour. Defatted sesame seed flour when incorporated into this blend at a ratio not more than 5% may aid in the production of organoleptically acceptable enriched gluten-free sorghum:Cardaba banana:defatted sesame cookies that could offer nutritional and health benefits for both gluten-sensitive and non-gluten-sensitive consumers.
Graphical Abstract
Association of various factors related to mastoid buffer and middle ear ventilation in etiopathogenesis of squamous chronic otitis media—a cross-sectional study
Authors: Murali Mithula , Jain Shraddha , Hande Vaidehi , Singh Chandraveer , Deshmukh P. T. , Gaurkar Sagar , M Smriti V. , Patil Nimisha 
Published: July 2023

Abstract
Background
Active squamous chronic otitis media (COM) is an entity with a deep retraction pocket of the pars tensa or flaccida that has retained debris of squamous epithelial where the fundus cannot be visualized involving the pars flaccida or pars tensa, associated with cholesteatoma. Eustachian tube dysfunction (ETD) is a known etiological factor for squamous COM, based on Wittmack’s theory; however, there are very few recent studies in this regard. Contracted mastoid pneumatisation (diploic or primary sclerosis) and presence of Korner’s septum have also been implicated to be associated with middle ear pathology, with conflicting results.
Hence, the present study was undertaken to find out the association of three important factors, namely eustachian tube dysfunction, type of mastoid pneumatisation, and Korner’s septum related to mastoid buffer and middle ear ventilation in etiopathogenesis of active squamous chronic otitis media. The study also attempted to identify various conditions of nose and nasopharynx associated with ETD. This would enable us in appropriate surgical decision making with long term benefits in term of hearing and disease outcomes.

Results
Out of the total 37 patients, with active squamous chronic otitis media, it was observed that Eustachian tube dysfunction was found to be associated with 23 (62.16%). The majority of patients had a diploic/primary sclerosed mastoid pneumatization pattern which is 32 (86.48%) of patients. Korner’s septum was found to be associated with 13 (35.13%) patients of the total 37 patients with active squamous chronic otitis media. All these findings were found to be statistically significant.

Conclusion
In this study, we found that there was a statistically significant positive association of all etiological factors namely Eustachian tube dysfunction, contracted mastoid (diploic/primary sclerotic mastoid), and the presence of Korner’s septum with causation of active squamous otitis media. Out of these factors, occurrence of diploic mastoid seemed to be the most constant association. Eustachian tube dysfunction of mechanical type, associated with various nasal pathologies, most common was, deviated nasal septum.
Sensory quality and nutritional composition of carrot (Daucus carota L.) genotypes as affected by fertilization in production system in Cameroon
Authors: Djoufack Maxime Merlin Tonfack , Kouam Eric Bertrand , Foko Edith Marius Kouam , Anoumaa Mariette , Kaktcham Pierre Marie , Zambou François Ngoufack 
Published: July 2023

Abstract
Background
Recommendations for fertilizer use in agriculture do not take into account the growing region and the source of the organic matter. In addition, vegetable growers are unaware of the quantities of fertilizer to be applied during cultivation. Accordingly, there are increasing complaints about the poor quality of the vegetables produced which is likely associated to the type and the dose of fertilizer used. Therefore, the objective of this work was to determine the probable origin of poor carrot quality in production basins in Cameroon. The factors consisted of five carrot genotypes and nine fertilizer types arranged in the field in a split-split plot experimental design. The sensory quality of the carrot samples was assessed by a quantitative descriptive test. The nutritional value was determined according to the treatments performed.

Results
The results of this study showed that both the sensory quality and nutritional value of carrots significantly depend on the variety, and the type and dose of fertilizer used. However, the variety New Kuroda treated with 10 t ha−1 of chicken manure and the unfertilized variety Vanessa F1 were recorded as having the best sweetness and overall acceptability scores. The best nutrient parameters such as total carbohydrate, proteins, ash, cellulose, NDF and ADF were obtained with the carrot varieties New Kuroda grown with a combination of chemical fertilizer (300 kg ha−1) + chicken manure (10 t ha−1), Pamela + unfertilized, Madona fertilized with 10 t ha−1 chicken manure, with 600 kg ha−1 chemical fertilizer + 5 t ha−1 chicken manure or not fertilized, Amazonia fertilized with 300 kg ha−1 chemical fertilizer and Vanessa F1 fertilized with a combination of 600 kg ha−1 chemical fertilizer + 5 t ha−1 of chicken manure.

Conclusion
Carrots with good sensory quality such as sweetness and deep orange colour were obtained with unfertilized Vanessa F1 variety. The variety Amazonia fertilized with 300 kg ha−1 chemical fertilizer provided good nutritional parameters including carotenoids, fibres, carbohydrates proteins and lipids.
How can we overcome health inequalities in psychiatry?
Authors: Monk-Cunliffe Jonathan 
Published: July 2023

SummaryHealth inequalities in psychiatry are well established, with people living in poverty and those from minoritised groups receiving different care and experiencing worse health outcomes. Psychiatric patients experience significant differences in life expectancy compared with the general population. This article explores changes within psychiatric services and public health interventions that could address health inequalities and asks why this has not happened yet.
Synchronization in networks of coupled oscillators with mismatches
Authors: Nazerian Amirhossein , Panahi Shirin , Sorrentino Francesco 
Published: July 2023

Abstract
This perspective reviews the subject of synchronization in networks of coupled non-phase oscillators in the presence of parametric mismatches. We first discuss the case of small parametric mismatches, for which the conditions for stability of the synchronous solution are the same as in the case of identical oscillators, but the synchronization error increases with the size of the mismatches. We then analyze the case of larger parameter mismatches and provide an explanation for why parameter mismatches sometimes hinder and sometimes enhance stability of the synchronous solution.
A multi-site, non-randomized study of the feasibility and acceptability of a family-led postnatal care model in the Ada District, Ethiopia
Authors: Bekele Gadise , Berhanu Della , Wolde Konjit , Teshite Dedefo , Worku Walelegn , Hyre Anne , Noguchi Lisa , Worku Alemayehu 
Published: July 2023

Background: Postnatal care is a critical intervention to reduce newborn and maternal mortality in high-mortality settings. However, it is underutilized in many countries. Family-led postnatal care (FPNC) is an innovative postnatal care service delivery model that leverages self-care principles to address key barriers identified in the Ethiopian context, including women’s preference to stay home in the first week after delivery and receive support from trusted family members. Utilizing an improved discharge process, coupled with user-friendly monitoring devices made available as a home care kit kept with preferred community custodians, this self-care model for postnatal care will be evaluated as a potential solution to very low coverage of postnatal care in the first week of life. Methods: The study will use mixed sequential methods: quantitative pre-intervention and post-intervention survey and phenomenological qualitative study. Four health centers in Ada Districtof Oromia, Ethiopia will be purposively selected. A pre-intervention survey will measure coverage and content of postnatal checks and care-seeking behavior. Health centers will then implement family led postnatal care. Once FPNC is initiated, post-intervention quantitative data will be collected. Approximately 218 postnatal women are to be included in the quantitative survey. Qualitative interviews with approximately 20 mothers, 20 partners, 20 families, eight health managers, 12 postnatal discharge counselors, 20 health extension workers, and eight home care kit custodians will be conducted. A quantitative measurement of sustainability six months after the endline will also be assessed. Conclusions: Optimally, the study will contribute evidence to inform decision makers locally and globally on whether FPNC is a feasible and acceptable service delivery model for postnatal care, and whether it improves women’s empowerment and/or increases men’s support and connection to women and newborns in the early postnatal period.
National health insurance contribution to family planning program funding in Indonesia: A fund flow analysis
Authors: Wahdi Amirah Ellyza , Sutanto Edward , Setyawan Althaf , Astrini Yufan Putri , Adani Nadhila , Mardani Halimah , Maulana Nirwan , Pattnaik Anooj , Trihono Trihono , Wilopo Siswanto Agus 
Published: July 2023

Background: Launched in 2014, Indonesia’s national health insurance system (JKN) aimed to provide universal health coverage, including contraceptive services, to its population. We aim to evaluate the contribution of JKN to the overall spending for the family planning program in Indonesia. Methods: Data from the Indonesian Demographic Health Survey, Survey on Financial Flows for Family Planning, Indonesia Motion Tracker Matrix, World Population Prospect, and Indonesian ministries’ budget accountability reports were entered into the CastCost Contraceptive Projection Tool to define budgetary allocation and spending for the family planning program at the national level in 2019. Results: Indonesia’s family planning program in 2019 was financed mostly by the national budget (64.0%) and out-of-pocket payments (34.6%). There were three main ministries responsible for family planning financing: the National Population and Family Planning Board (BKKBN) (35.8%), the Ministry of Finance (26.2%), and the Ministry of Health (2.0%). Overall, JKN contributed less than 0.4% of the funding for family planning services in Indonesia in 2019. The majority of family planning spending was by public facilities (57.3%) as opposed to private facilities (28.6%). Conclusion: JKN’s contribution to funding Indonesia’s family planning programs in 2019 was low and highlights a huge opportunity to expand these contributions. A coordinated effort should be conducted to identify possible opportunities to realign BKKBN and JKN roles in the family planning programs and lift barriers to accessing family planning services in public and private facilities. This includes a concerted effort to improve integration of private family planning providers into the JKN program.
nf-core/clipseq - a robust Nextflow pipeline for comprehensive CLIP data analysis
Authors: West Charlotte , Capitanchik Charlotte , Cheshire Chris , Luscombe Nicholas M. , Chakrabarti Anob , Ule Jernej 
Published: July 2023

Crosslinking and immunoprecipitation (CLIP) technologies have become a central component of the molecular biologists’ toolkit to study protein-RNA interactions and thus to uncover core principles of RNA biology. There has been a proliferation of CLIP-based experimental protocols, as well as computational tools, especially for peak-calling. Consequently, there is an urgent need for a well-documented bioinformatic pipeline that enshrines the principles of robustness, reproducibility, scalability, portability and flexibility while embracing the diversity of experimental and computational CLIP tools. To address this, we present nf-core/clipseq - a robust Nextflow pipeline for quality control and analysis of CLIP sequencing data. It is part of the international nf-core community effort to develop and curate a best-practice, gold-standard set of pipelines for data analysis. The standards enabled by Nextflow and nf-core, including workflow management, version control, continuous integration and containerisation ensure that these key needs are met. Furthermore, multiple tools are implemented (e.g. for peak-calling), alongside visualisation of quality control metrics to empower the user to make their own informed decisions based on their data. nf-core/clipseq remains under active development, with plans to incorporate newly released tools to ensure that pipeline remains up-to-date and relevant for the community. Engagement with users and developers is encouraged through the nf-core GitHub repository and Slack channel to promote collaboration. It is available at https://nf-co.re/clipseq.