bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multilevel argument‐based approach to validation and interpretation of safety climate scores
Authors: Bazzoli Andrea , French Brian F. 
Published: January 2025

AbstractWe introduce Kane's Interpretation Use Argument approach to establishing a measure's validity to organizational scientists and extend it to multilevel constructs. First, we review five types of inferences (i.e., domain description, scoring, generalization, extrapolation and implication) that could be targeted by applied psychologists and management scholars, enumerate the types of analyses that fall under each of the inferences and describe how they help provide a clearer overview to support score use. We apply this framework to organize evidence related to a short and theory‐driven scale that measures safety climate by developing six potential factor structures for safety climate scores, along with their meaning and interpretations, selecting items from the SOPS survey and analysing data from the 2021 and 2022 SOPS datasets, two large government surveys from the health care industry (N = 77,674 and 183,573, respectively) that feature a nested data structure on three levels. A shared construct model was the model that received the most empirical support. We conclude with a discussion of the implications of measuring safety climate using shared construct models, the limitations of the SOPS survey, and we trace a map for future efforts to constructing a validity argument.
Protective Effects of Melatonin on Kidney Function Against Contrast Media‐Induced Kidney Damage in Patients With Chronic Kidney Disease: A Prospective, Randomized, Double‐Blinded, Placebo‐Controlled Trial
Authors: Kusirisin Prit , Apaijai Nattayaporn , Noppakun Kajohnsak , Kuanprasert Srun , Chattipakorn Siriporn C. , Chattipakorn Nipon 
Published: January 2025

ABSTRACTPatients with chronic kidney disease (CKD) are at increased risk of acute kidney injury following exposure to contrast media. We evaluated the effect of melatonin, a potent antioxidant, as a protective strategy against contrast‐induced acute kidney injury (CI‐AKI), with a focus on molecular mechanisms. We randomized patients with an eGFR < 60 mL/min/1.73 m2 undergoing coronary angiography (CAG) into melatonin (10 mg twice daily) or placebo groups. Treatment started 48 h before CAG and continued for a total of 6 days. Peripheral blood mononuclear cells (PBMCs) were collected at baseline, at the time of CAG, and at 6, 24, 48, 72 h, and Day 30 post‐procedure. The primary outcome was the incidence of CI‐AKI; secondary outcomes included kidney function, oxidative stress, mitochondrial function, and cell death pathways. Forty patients were randomized into either the treatment or placebo group. All subsequent analyses were conducted on an as‐treat basis. The incidence of CI‐AKI was significantly lower in the melatonin group compared to the placebo group (25% vs. 60%, p = 0.025). The melatonin group showed a significantly smaller percentage change in plasma neutrophil gelatinase‐associated lipocalin (NGAL) at all time points. In the PBMC study, cellular oxidative stress was significantly reduced in the melatonin group at each time point, and mitochondrial oxidative stress was lower at 48–72 h. Mitochondrial respiration improved significantly, and both necrosis and necroptosis were reduced at 24 h. Melatonin administration effectively reduced the incidence of CI‐AKI in CKD patients undergoing CAG. This protective effect was associated with decreased oxidative stress, enhanced mitochondrial function, and reduced cell death, suggesting melatonin as a promising preventive strategy for CI‐AKI.Trial Registration: TCTR20210123004
Prevalence and associations of self‐reported sleep problems in a large sample of patients with Parkinson's disease
Authors: Asadpoordezaki Ziba , Henley Beverley M. , Coogan Andrew N. 
Published: January 2025

SummarySleep problems are important comorbid features of, and risk factors for, neurodegenerative diseases such as Parkinson's disease (PD). To assess the prevalence and associations of sleep problems in patients with PD we analysed data from almost 54,000 participants in the Fox Insight study, including data from 38,588 patients with PD. Sleep problems are common in PD, with ~84% of respondents with PD reporting difficulty falling or staying asleep. Experiences of insomnia, restless leg syndrome, vivid dreams, acting out dreams, and the use of sleep medication are over‐represented in patients with PD compared with matched healthy controls. Male sex and PD onset before the age of 50 were also associated with a greater risk of sleep problems. A physician diagnosis of insomnia was associated with more symptoms of depression, impairment of cognition‐dependent independence, and a lower quality of life. Sleep problems were also associated with a higher prevalence of OFF periods compared with PD patients without sleep problems. 6.7% of PD patients endorsed sleep complaints as their most bothersome symptom, and reported non‐specific poor sleep quality as the most common sleep problem. These patients also had a better quality of life and lower depression and cognitive impairments than patients for whom postural instability was their most bothersome symptom, indicating the relative burden of sleep problems is contextualised by the severity of motor symptoms. Overall, these findings reinforce the high prevalence of sleep problems in a very large sample of PD patients, and indicate important associations of sleep problems with daily function and quality of life in PD.
Long‐Term Immunity and Anamnestic Response Following Hepatitis B Vaccination: A Systematic Review and Meta‐Analysis
Authors: Ramrakhiani Hannah , Le Michael H. , Kam Leslie , Nguyen Brian , Yeo Yee Hui , Levesley Charles R. , Gudapati Surya , Barnett Scott , Cheung Ramsey , Nguyen Mindie H. 
Published: January 2025

ABSTRACTUsing a systematic review and meta‐analytic approach, this study determined the durability of HBV immunity and the prevalence of anamnestic response to a booster HBV vaccine dose in individuals previously vaccinated with a 3‐dose HBV vaccine series as children or adolescents. Two researchers independently searched PubMed, Embase and Cochrane from inception to 6/1/2023 and performed data extraction. Studies that included individuals with significant comorbidities or < 5 years of follow‐up were excluded. Of 2517 potential studies, we analysed 91 eligible studies (193,359 individuals from 208 cohorts [some studies provided data for more than one cohort]). Median age at vaccination was 0 years (range: 0–20.00). After a median follow‐up of 10.15 years (range: 5–35), 63.2% (95% CI: 59.3–67.0) retained HBV immunity. HBV immunity declined by 6.62% per follow‐up year (Ptrend < 0.0001). In meta‐regression adjusting for vaccine type, follow‐up time and geographic location, age at vaccination was significantly associated with retaining HBV immunity (adjusted odds ratio [aOR] 1.12 per year, p < 0.0001). Anamnestic response rate (44 studies, 66 cohorts, 29,040 patients) was 90.34% (95% CI: 86.84–92.98), with highest rates in Europe and Asia, but only study setting (clinical versus community‐based: aOR 2.21, p = 0.034) was an independent factor. HBV immunity prevalence was about 60% after 10 years following childhood vaccination. Anamnestic response rate was about 90% and varied by study setting. Testing for immunity should be considered in individuals with high exposure risk and distant vaccination history with booster as needed.
Characterization of post‐ictal clinical signs in dogs with idiopathic epilepsy: A questionnaire‐based study
Authors: Nagendran Aran , Nettifee Julie A. , Carter Dani , Muñana Karen R. 
Published: January 2025

AbstractBackgroundPost‐ictal (PI) clinical signs are a key defining stage of seizure manifestation in dogs. However, this phase remains poorly understood.ObjectivesTo further characterize PI signs and their relation to other parts of a seizure, and understand the owner's perception of how PI signs affect the quality of life (QOL) of the dog.AnimalsEight‐seven dogs with a diagnosis of idiopathic epilepsy from a single institution.MethodsThe prospective questionnaire‐based study surveying owners of dogs previously and newly diagnosed with idiopathic epilepsy.ResultsPost‐ictal signs were identified in 79/87 dogs, 5/5 of dogs with focal seizures and 74/82 of dogs with generalized seizures. Median duration of PI signs was 30 minutes (range, 5‐4320 minutes). The most common PI signs reported were disorientation (50/79) and wobbliness or clumsiness (49/79). Within a year, a change in PI signs was seen in 18/79 dogs. The administration of benzodiazepines was significantly associated with an increase in duration of PI signs (P = .04). Post‐ictal signs had more impact on dogs' quality of life compared with ictal signs (P < .01). Groupings of co‐existing PI signs identified included disorientation, blindness and deafness.ConclusionPost‐ictal signs are a commonly reported aspect of seizures in dogs with idiopathic epilepsy, both in focal as well as generalized seizures. Co‐existence of signs could provide some valuable insight into the relevance of this particular phase of a seizure. Owner‐reported signs and documentation emphasize the need for a better understanding of PI signs in dogs with idiopathic epilepsy.
Enhancing tilapia intestinal health and growth: Response surface methodology‐optimized Schizochytrium limacinum and Lactococcus lactis supplementation
Authors: Wang Yan , Tang Wei , Chen Siming , Zhao Zichen , Huang Qingqin , Li Jianlong , Lin Chuan , Deng Hengwei , Zhong Zhihong , Guo Weiliang , Wang Shifeng , Sun Yun , Zhou Yongcan 
Published: January 2025

AbstractTo improve the growth of genetically improved farmed tilapia (GIFT), the supplementation of Schizochytrium limacinum and Lactococcus lactis was sequentially optimized by a single‐factor method and central composite design combined with response surface methodology (CCD‐RSM) using a developed desirability function (Df) as the response value. The optimum supplementary prescriptions obtained by the single‐factor method and CCD‐RSM were alone 1.5% S. limacinum, alone 1 × 107 CFU/g L. lactis, and 1.22% S. limacinum + 4.01 × 107 CFU/g L. lactis respectively. The Df of the tilapia fed with the diets supplemented with these optimum prescriptions were 0.53, 0.54, and 0.61, respectively. The Df, weight gain rate (WGR), and feed conversion rate (FCR) of the tilapia fed with the optimum prescriptions obtained by CCD‐RSM were significantly higher than those of the tilapia fed with the diets obtained by single‐factor experiments and the basic diet for 28 days. Furthermore, the results of CCD‐RSM can show that there were significant interactive effects between S. limacinum and L. lactis on trypsin, α‐amylase, lipase, total cholesterol (TC)−1 and low‐density lipoprotein cholesterol (LDL‐C)−1, and Df, but those of single‐factor method cannot.
High Level of Predation of Atlantic Salmon Smolt During Marine Migration
Authors: Vollset Knut Wiik , Berhe Saron , Barlaup Bjørn T. , Åtland Åse , Isaksen Trond Einar , Wiers Tore , Landro Yngve , Normann Eirik Straume , Lennox Robert J. 
Published: January 2025

ABSTRACTThe early marine migration of Atlantic salmon through coastal areas and fjords is a potential bottleneck in the migration where high losses can occur. Here we use a displacement experiment to attempt to identify mortality hotspots or bottlenecks within a fjord in Western Norway, where earlier studies have indicated exceptionally high mortality and poor recruitment over multiple years. Atlantic salmon (Salmo salar) smolts from the Dale River were tagged with prediction sensor acoustic transmitters and released at one of six sites within the fjord, which was covered by several receivers up to a large bridge across the fjord. There was a consistently high level of mortality throughout the migration, where none of the smolts from the first three release groups made it past the bridge to the outer fjord (mean survival = 17%). There was a strong effect of release distance on survival, suggesting that releasing the fish further out in the fjord and closer to the bridge improved survival. Mark‐recapture analysis revealed the importance of the predation sensors for calculating survival; without using the information from predation sensors, survival through the system was high and the confidence bands were narrow; however, knowing which individuals had been eaten reduced estimated survival substantially. Once smolts arrived at the end of the tracking array at the bridge, passage of the bridge was slow, and we found that salmon spent time moving laterally along the structure rather than directly through it and appeared to be delayed.
An Inter‐ and Intra‐Rater Agreement Assessment of Two Novel Classification Systems for Coronal Imbalance in Adult Scoliosis and Spine Deformity
Authors: Mardan Muradil , Mamat Mardan , Yasin Parhat , Cai Xiao‐Yu , Fan Guo‐Jun , Xu Tao , Li Bo , Chen Peng‐Bo , Lu Ze‐Yu , Sheng Wei‐Bin , Jiang Sheng‐Dan , Jiang Lei‐Sheng , Zheng Xin‐Feng 
Published: January 2025

ABSTRACTObjectiveCoronal malalignment is a common feature of adult spinal deformity, and accurate classification is essential for diagnosis and treatment planning. However, variations in interpretation among clinicians can impact classification consistency. By assessing the reliability and applicability of these systems across different medical experts, this study seeks to establish a standardized approach to enhance clinical outcomes. This study aimed to evaluate the inter‐ and intra‐observer agreement of two classification systems for coronal malalignment in adult spinal deformity patients, as proposed by Qiu et al. and Obeid et al.MethodsWe analyzed 70 cases of adult spinal deformity collected between January 1, 2010, and April 20, 2023, using the classification systems proposed by Qiu et al. and Obeid et al. To assess inter‐ and intra‐rater agreement, the same group of researchers re‐evaluated all cases in a random order after a 4‐week interval. We used the kappa statistic (κ) for inter‐ and intra‐rater agreement assessment.ResultsQiu's classification system: Inter‐rater agreement: Substantial agreement (κ = 0.76; 95% CI: 0.72–0.80) for Type A, Type B, and Type C. Intra‐rater agreement: Nearly perfect agreement (κ = 0.83; 95% CI: 0.78–0.89) within raters for Type A, Type B, and Type C.Obeid's classification system: Inter‐rater agreement: Almost perfect agreement (κ = 0.85; 95% CI: 0.83–0.87) for Type 0, Type 1, and Type 2. Complete system: Substantial agreement (κ = 0.68; 95% CI: 0.65–0.71) for all types and subtypes. Intra‐rater agreement: Almost perfect at the type level (κ = 0.88; 95% CI: 0.83–0.93) and substantial at the subtype level (κ = 0.75; 95% CI: 0.65–0.85).ConclusionsThe research findings indicate a high level of agreement between the classification system described by Qiu et al. and the classification system proposed by Obeid et al. This agreement supports the widespread adoption and utilization of these classification systems in future clinical studies.
Physical function estimates change in pain following IIPT among children with chronic pain
Authors: Seth Mayank , Bentley Katherine , Hottinger Kathryn , Vieni Kate , Reineke Anke , Dalal Pritha 
Published: January 2025

AbstractIntroductionChronic pain can negatively impact a child's quality of life. Pediatric Intensive Interdisciplinary Pain Treatment (IIPT) programs aim to improve overall functioning despite pain through various rehabilitative strategies. It is, however, unclear whether improved function corresponds to self‐reported decrease in pain levels. Hence, the purpose of this study is to examine the relationship between changes in physical function and perceived pain among children with chronic pain who have undergone inpatient IIPT.Materials and MethodsA secondary analysis of pre‐existing databases of IIPT from two different inpatient acute rehabilitation programs was carried out. Children and adolescents (N = 309; age = 16.2 ± 2.6; 79% females) with chronic pain who attended on average 4‐week inpatient IIPT from Nov 2011 to Jan 2023 were included. Participants completed pain intensity (Numerical Pain Rating Scale) and self‐reported function measures (Lower Extremity Functional Scale [LEFS], Upper Extremity Functional Index [UEFI], Canadian Occupational Performance Measure [COPM]‐Performance, and COPM‐Satisfaction) at admission and discharge.ResultsChange in self‐reported physical function was significantly associated with change in pain from admission to discharge. After covariate adjustment, self‐reported physical function (per the LEFS, UEFI, COPM‐Performance, and COPM‐Satisfaction) explained 19.8%, 7.8%, 12.0%, and 8.6% of the variance in change in pain, respectively. These measures of self‐reported physical function further distinguished between minimal (<30%) and moderate (≥30%) pain reduction.ConclusionsSelf‐reported functional gains during IIPT are associated with greater change in perceived pain. Moreover, measures of self‐reported physical function can help identify children at risk of minimal pain reduction post‐IIPT.
An Indoor Laser Inertial SLAM Method Fusing Semantics and Planes
Authors: Wu Chaohong , Zhong Ruofei , Hu Qingwu , Wu Haiyang , Wang Zhibo , Xu Mengbing , Yuan Xinze 
Published: January 2025

ABSTRACTLiDAR‐based simultaneous localization and mapping (LiDAR SLAM) technology is widely used for high‐precision 3D mapping in complex environments, especially in the fields of non‐contact remote sensing and geographic information systems. However, affected by factors such as sensor errors and dynamic environment, SLAM methods are prone to accumulate errors, which affect its accuracy and reliability. In this article, we propose a LiDAR SLAM odometry optimization method, Semantic and Planar Constraint SLAM (SPC‐SLAM). The method strengthens the effectiveness of planar constraint by introducing semantic information and combines with factor graph optimization to improve the accuracy of key‐frame pose estimation. In addition, we design a pseudo‐truth‐based threshold judgment mechanism for deciding whether it is necessary to perform semantic segmentation steps to ensure the efficiency of SLAM as much as possible. We conducted comparative experiments on part of public data in SubT‐MRS Dataset and self‐acquired campus data. The results show that in the complex indoor environments we chose, LIO‐SAM is unable to complete the whole mapping under the initial parameters, and the overall absolute trajectory error of SPC‐SLAM is reduced by about 65% compared with the FAST‐LIO2, demonstrating the potential of the method for application in accurate indoor mapping and 3D imaging.
Guardians of the Game: UV‐Specific Skin Cancer Prevention by Coaches in Outdoor Sports
Authors: Leer Sophie , Ehls Clara , Schneider Sven 
Published: January 2025

ABSTRACTBackgroundDue to the global rise in UV radiation, the prevalence of skin cancer is increasing significantly, with outdoor athletes being identified as a particularly vulnerable population group.MethodsThis nationwide, cross‐sectional study was conducted among adult coaches from the 10 largest outdoor sports associations in Germany. Their applied prevention measures and the potential for further improvement in prevention were evaluated by guideline based scores (range [0–100]). Additionally, sport‐, coach‐, and club‐specific variables were analysed and barriers that prevent comprehensive UV prevention were identified.ResultsThe UV prevention practice of the 1200 participating coaches averaged 53.43 ± 16.37 [0.00–95.31], while the potential UV prevention options were assessed at a comparatively higher value of 58.82 ± 17.53 [0–100]. Notably, the proper use of sunscreen emerged as the most neglected preventive measure. Coaches identified the greatest potential for improvement in sunscreen renewal, water‐resistant sun protection products and sunglasses. The study also revealed significant differences in UV protection practices between different sports, with soccer, tennis, and swimming exhibiting the most pronounced deficits. Factors such as coach qualification and experience, as well as club size and the size of training groups influenced the level of UV protection implemented. Many coaches cited various implementation obstacles such as fixed training times and resource constraints.ConclusionThe study highlights specific areas for improvement in UV protection practices in outdoor sports, considering differences on sport, coach, and club levels. The significant number of active athletes in these sports underscores the public health importance of addressing UV protection in this field.
Young and informed? Adolescents' perceptions of ‘left’ and ‘right’
Authors: Durmuşoğlu Linet R. , van der Brug Wouter 
Published: January 2025

AbstractThe terms ‘left’ and ‘right’ are often used in political communication to describe the main differences between parties. Adolescents who are learning about politics also learn to understand the party system (partially) through the lens of the left–right spectrum. This study examines adolescents' perceptions of parties' left–right positions and their substantive understandings of ‘left’ and ‘right’ with an innovative battery of items. We use original survey data from Dutch adolescents and their parents to investigate differences and similarities in their perceptions of party positions and the meanings they attach to ‘left’ and ‘right.’ Our findings show that adolescents' understanding of ‘left’ and ‘right’ is remarkably similar to that of the generation of their parents. Even though left–right perceptions of adolescents seem to be influenced by their own parents, adolescents form their perceptions mostly in line with those of the median voter, particularly adolescents that are more engaged and knowledgeable.
A NAC transcription factor NAC50 regulates Fe reutilization in Arabidopsis under Fe‐deficient condition
Authors: Huang Jing , Tu Chun Yan , Wang Hao Yu , Zhang Qiang , Shen Ren Fang , Zheng Lu , Zhu Xiao Fang 
Published: January 2025

AbstractA lack of iron (Fe) inhibits the growth and development of plants, leading to reduced agricultural yields and quality. In the last ten years, numerous studies have focused on the induction of Fe uptake and translocation under Fe deficiency, but the regulatory mechanisms governing Fe reutilization within plants are still not well understood. Here, we demonstrated the involvement of the NAM/ATAF1/2/CUC2 (NAC) transcription factor NAC50 in response to Fe shortage. The content of soluble Fe was greatly reduced in nac50 mutants, leading to increased chlorosis in the newly emerging leaves under the Fe‐deficient condition. Subsequent investigation revealed that the cell wall of the nac50 mutants' roots accumulated more Fe, along with an increment in hemicellulose content, indicating that a cell wall‐associated Fe reutilization pathway was involved in the NAC50‐regulated Fe insufficiency response. Interestingly, the expression of NINE‐CIS‐EPOXYCAROTENOID DIOXYGENASE 3 (NCED3), a key enzyme in the abscisic acid (ABA) biosynthetic pathway, was down‐regulated in the Fe‐deficient nac50 mutants, resulting in decreased endogenous ABA level and Fe‐deficient sensitive phenotype. Since no direct relationship was observed between NAC50 and NCED3, this suggests a potential role of NAC50 in mediating the ABA accumulation. Moreover, exogenous ABA application in the nac50 mutant restored Fe deficiency resistance to the level observed in wild‐type plants (WT), indicating that NAC50 induced the cell wall Fe reutilization potentially through the regulation of ABA accumulation.