bluuebunny/crossref_metadata_2025_split huggingface dataset:
NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ ĐÁNH GIÁ CHẤT LƯỢNG CUỘC SỐNG CỦA BỆNH NHÂN U NGUYÊN BÀO MEN XƯƠNG HÀM DƯỚI PHẪU THUẬT
Authors: Lê Nguyên Lâm , Trần Quốc Huy 
Published: July 2023

Đặt vấn đề: U nguyên bào men xương hàm là loại u có nguồn gốc từ cơ quan tạo răng, lành tính và chiếm tỷ lệ 10% trong các loại u vùng hàm mặt. Sự phát triển, xâm lấn của u thường âm thầm, liên tục, gây biến dạng mặt trầm trọng nếu kích thước u lớn. Phương pháp phẫu thuật triệt để được chấp nhận rộng rãi và được xem như là phương pháp điều trị an toàn Tuy nhiên, hậu quả của các phương pháp phẫu thuật này đều có những tác động sâu sắc và lâu dài đến chất lượng cuộc sống của bệnh nhân. Muc tiêu: Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và đánh giá chất lượng cuộc sống của bệnh nhân u nguyên bào men xương hàm dưới phẫu thuật. Đối tượng, thời gian và địa điểm nghiên cứu: Mẫu nghiên cứu bao gồm những bệnh nhân được chẩn đoán xác định u nguyên bào men xương hàm dưới dựa trên lâm sàng, phim X quang và giải phẫu bệnh tại Bệnh viện Răng Hàm Mặt Thành Phố Hồ Chí Minh. -Địa điểm nghiên cứu: Khoa Phẫu Thuật Hàm Mặt Bệnh Viện Răng Hàm Mặt Thành Phố Hồ Chí Minh. -Thời gian nghiên cứu: từ tháng 3/2021 đến tháng 9/2022. Nghiên cứu được thiết kế theo phương pháp mô tả cắt ngang.Cỡ mẫu 30 đối tượng.Chọn mẫu thuận tiện. Kết quả: Triệu chứng thường gặp nhất là gồ xương đơn thuần tại chỗ (56,7%) và mật độ u thường cứng (63,3%). Kích thước u nguyên bào men được đo trên phim X quang từ 3-10 cm chiếm 70%. U nguyên bào men xương hàm dưới thường xuất hiện liên quan đến vùng cành ngang (50%) và có dạng đa hốc (63,3%). Sau phẫu thuật u nguyên bào men 7 ngày, yếu tố ảnh hưởng nhiều đến chất lượng cuộc sống của bệnh nhân là nhai, nuốt, phát âm có sự khác biệt mang ý nghĩa thống kê so với trước khi phẫu thuật (p<0.05).Chất lượng cuộc sống chung của bệnh nhân sau phẫu thuật 3 tháng cải thiện so với trước phẫu thuật và sau phẫu thuật 7 ngày và sự khác biệt có ý nghĩa thống kê (p<0,05). Kết luận: Chất lượng cuộc sống chung của bệnh nhân sau phẫu thuật 3 tháng cải thiện so với trước phẫu thuật và sau phẫu thuật 7 ngày
Overview of seismic stratigraphic referencing methods in conditions of limited or substandard set of initial well data
Authors: Sanatova Zhaniya A. , Kaliyev Dias T. 
Published: July 2023

Background: Well tying is an integral part of seismic interpretation both at the stage of structural and dynamic analysis. Linking seismic and well data is a critical process that allows you to link geological objects identified from seismic data with actual data obtained from wells, because. it is based on the relationship between the lithological composition of the deposits that make up the section under study and the characteristics of the reflections. Seismic data are in most cases presented on a time scale, while well data are on a depth scale, and in order to calibrate them, it is necessary to select a velocity law and establish a time-depth relationship.
Aim: This article aims to deepen the understanding of the importance of quality control of initial well data to improve the result of seismic stratigraphic tying and increase the efficiency of geological exploration, as well as to propose methods to improve the quality and efficiency of tying..
Materials and methods: Methods for correcting the readings of acoustic logging are described, various algorithms for tying seismic and well data are given.
Results: The paper considers the reasons for the distortion of the values of the initial well data, examples of data quality analysis, suggests options for how to conduct a seismic stratigraphic tie in the conditions of a limited or initially substandard set of initial data and obtain reliable depth-velocity dependences for wells.
Conclusion: Conducting quality control and, if necessary, correcting the original well data is a critical step to improve the accuracy of the final results of seismic interpretation. It is important to note that even with limited and low quality input data, it is possible to obtain depth-time dependencies. However, the results of the work show that editing and amending the original logs significantly improve the quality and detail of the seismic stratigraphic tie.
Inhibidores RHO quinasa en el tratamiento del glaucoma de ángulo abierto.
Authors: Illescas-Zuña German Alexander , Cervantes-Anaya Luis Alberto 
Published: July 2023

Introducción: El glaucoma es un problema de salud pública mundial y es una enfermedad multifactorial que puede pasar desapercibida por ser inicialmente asintomática. A pesar de los avances en los programas de prevención del glaucoma. El tratamiento médico sigue siendo la piedra angular para mejorar el bienestar de los pacientes con glaucoma.
Objetivo: Determinar el uso de inhibidores de rho quinasa en el tratamiento del glaucoma de ángulo abierto.
Metodología: Revisión bibliográfica tipo narrativa, se efectuaron búsquedas en bases de datos de salud como Elsevier, Springer Link, Cochrane Library, PubMed, Dialnet, Scopus. Se emplearon palabras claves los cuales fueron términos de los descriptores en ciencias de la salud (DeCS) y (MeSH), al mismo tiempo, se utilizaron operadores Booleanos como: “AND”, “NOT” y “OR”. De acuerdo con los criterios de elegibilidad, 8 artículos fueron analizados e incluidos en esta revisión.
Resultados: En base a los objetivos y los 8 artículos incluidos en esta revisión, se obtuvo como resultado que los inhibidores rho quinasa prometen tener, pero no demuestran tener una eficacia mayor a los fármacos de primera línea usados en el glaucoma por la cual lo convierte en un fármaco antiglaucomatoso adyuvante y no en una terapia de primera línea. Las principales reacciones adversas provocadas por el tratamiento son: hiperemia conjuntival, hemorragia conjuntival, conjuntivitis alérgica, ojo seco y blefaritis.
Conclusiones: El tratamiento con inhibidores rho quinasa al reducir la PIO en pacientes con glaucoma, promete tener una gran eficacia cuando se utilizan como terapia combinada. En cuanto a la seguridad, sus efectos adversos generalmente fueron leves y desaparecieron por sí solos.
Pleomorphic Adenoma of the Hard Palate:A Multidisciplinary Approach
Authors: Ganapati L Dharmashala  , S Vinayak E  , Padmini Bhimsen  , Mamta Hegde  
Published: July 2023

Pleomorphic adenoma is the most common salivary gland tumor accounting for 80% of all major salivary gland tumors. It is a benign salivary gland neoplasm that constitutes 3% to 10% of the neoplasms in the head and neck region.1 Salivary gland neoplasms represents less than 1% of all tumors. This article is being showcased as a special case due to the fact it was done at a Taluk Hospital and also because ENT and oromaxillofacial surgeons were involved during the surgery.
Examining the effects of negative emotion and interviewing procedure on eyewitness recall
Authors: Snow Mark D. , Eastwood Joseph 
Published: July 2023

AbstractWitnessing or experiencing a crime can be emotionally distressing and this emotional reaction can affect the formation and retrieval of event‐related memory. Extant eyewitness research, however, has generated inconsistent conclusions regarding the effects of emotional arousal on eyewitness memory. In the present experiment, we used a mock witness paradigm to attempt to remedy several methodological limitations that have persisted in the literature and shed light on the effects of emotional memory within an investigative interviewing context. Participants (N = 132) viewed either a Negative or Neutral video and either immediately or one week later provided their account of the video in a virtual interview procedure, consisting of either cognitive interview‐ based instructions or a free recall. Negative emotion was associated with selectively enhanced recall for the central aspects of the video. Participants who viewed the Negative video reported more details that were central to the target video than did those who viewed the Neutral video. The present findings highlight the potential for negative emotional events to lead to focally enhanced recall performance.
Research on environmental monitoring and governance of air contamination in the Beijing‐Tianjin‐Hebei region stemmed from spatiotemporal data collection
Authors: Zhao Ying 
Published: July 2023

AbstractFrom 2013 to now, Beijing‐Tianjin‐Hebei (Hereinafter referred to as “the region”) has carried out comprehensive air pollution governance, which has promoted the sustained and rapid development of the regional economy while significantly improving regional air quality. However, the spatial and seasonal differences in atmospheric quality are obvious, and the regional and structural problems are still prominent. There is a long way to go for new challenges of cooperate governance of PM2.5 and O3. Therefore, first, we should further deepen the joint prevention and control mechanism based on regional collaborative governance. Second, we should rely on technological innovation to impetus the upgrading of energy and industrial structure. Third, we should adjust the transportation structure and create a new pattern of transportation network. Fourth, we should improve the ecological compensation mechanism and give full play to the functions of ecological conservation areas. Fifth, we should think highly of the self‐purification capacity of the ecosystem and build urban forest parks. At last, we should Strengthen publicity and mobilization, and participate in joint governance through nationwide action.
A Bioglass‐Poly(lactic‐co‐glycolic Acid) Scaffold@Fibrin Hydrogel Construct to Support Endochondral Bone Formation
Authors: Jeyachandran Dhanalakshmi , Murshed Monzur , Haglund Lisbet , Cerruti Marta 
Published: July 2023

AbstractBone tissue engineering using stem cells to build bone directly on a scaffold matrix often fails due to lack of oxygen at the injury site. This may be avoided by following the endochondral ossification route; herein, a cartilage template is promoted first, which can survive hypoxic environments, followed by its hypertrophy and ossification. However, hypertrophy is so far only achieved using biological factors. This work introduces a Bioglass‐Poly(lactic‐co‐glycolic acid@fibrin (Bg‐PLGA@fibrin) construct where a fibrin hydrogel infiltrates and encapsulates a porous Bg‐PLGA. The hypothesis is that mesenchymal stem cells (MSCs) loaded in the fibrin gel and induced into chondrogenesis degrade the gel and become hypertrophic upon reaching the stiffer, bioactive Bg‐PLGA core, without external induction factors. Results show that Bg‐PLGA@fibrin induces hypertrophy, as well as matrix mineralization and osteogenesis; it also promotes a change in morphology of the MSCs at the gel/scaffold interface, possibly a sign of osteoblast‐like differentiation of hypertrophic chondrocytes. Thus, the Bg‐PLGA@fibrin construct can sequentially support the different phases of endochondral ossification purely based on material cues. This may facilitate clinical translation by decreasing in‐vitro cell culture time pre‐implantation and the complexity associated with the use of external induction factors.
Dual Photo‐Enhanced Interpenetrating Network Hydrogel with Biophysical and Biochemical Signals for Infected Bone Defect Healing
Authors: Jian Guangyu , Li Dize , Ying Qiwei , Chen Xu , Zhai Qiming , Wang Si , Mei Li , Cannon Richard D. , Ji Ping , Liu Wenzhao , Wang Huanan , Chen Tao 
Published: July 2023

AbstractThe healing of infected bone defects (IBD) is a complex physiological process involving a series of spatially and temporally overlapping events, including pathogen clearance, immunological modulation, vascularization, and osteogenesis. Based on the theory that bone healing is regulated by both biochemical and biophysical signals, in this study, a copper doped bioglass (CuBGs)/methacryloyl‐modified gelatin nanoparticle (MA‐GNPs)/methacrylated silk fibroin (SilMA) hybrid hydrogel is developed to promote IBD healing. This hybrid hydrogel demonstrates a dual‐photocrosslinked interpenetrating network mechanism, wherein the photocrosslinked SilMA as the main network ensures structural integrity, and the photocrosslinked MA‐GNPs colloidal network increases strength and dissipates loading forces. In an IBD model, the hydrogel exhibits excellent biophysical characteristics, such as adhesion, adaptation to irregular defect shapes, and in situ physical reinforcement. At the same time, by sequentially releasing bioactive ions such as Cu2+, Ca2+, and Si2+ ions from CuBGs on demand, the hydrogel spatiotemporally coordinates antibacterial, immunomodulatory and bone remodeling events, efficiently removing infection and accelerating bone repair without the use of antibiotics or exogenous recombinant proteins. Therefore, the hybrid hydrogel can be used as a simple and effective method for the treatment of IBD.
Microfluidic‐Assisted Interfacial Complexation of Extracellular Matrix Components to Mimic the Properties of Neural Tissues
Authors: Costa Rui R. , Caballero David , Soares da Costa Diana , Rodriguez‐Trujillo Romen , Kundu Subhas C. , Reis Rui L. , Pashkuleva Iva 
Published: July 2023

AbstractAnisotropy is an important cue for neural organization during morphogenesis and healing, contributing to the mechanical and functional properties of neural tissues. The ability to replicate such anisotropy in vitro holds great promise for the development of effective regeneration strategies. In this work, interfacial polyelectrolyte complexation (IPC) is applied to fabricate microfibers from charged ECM components without any chemical modification. Using flow‐focusing microfluidics, collagen (Col) and glycosaminoglycans (GAGs), such as chondroitin sulfate (CS) or heparin (Hep), form Col/CS and Col/Hep interfacial complexes that coalesce as IPC microfibers. These fibers are flexible and absorb large amounts of water but remain stable under physiological conditions. At these conditions, the tensile strength of the assembled Col/GAG microfibers is similar to the strength of the neural tissue. The fibers are biocompatible and biofunctional; PC12 neural cells adhere and orient longitudinally to the fibers. Moreover, Col/CS microfibers promote the formation of neural processes. The results demonstrate that the microfluidic‐assisted IPC complexation enables the assembly of ECM mimics by synergetic integration of anisotropic, chemical, and mechanical cues that boost the development of neural cells.
The effect of processing design and the stabilizing effect of nanostructures on the swelling and adsorption properties of polyvinylpyrrolidone macroporous ferrogels obtained through a cryogenic route
Authors: Scanone Ana C. , Romeo Hernán E. , Mendoza Zélis Pedro , Hoppe Cristina E. , Gonzalez Jimena S. 
Published: July 2023

AbstractThis paper reports the synthesis of macroporous polyvinylpyrrolidone (PVP) hydrogels modified with in‐situ generated magnetic nanoparticles (NPs). The hydrogels were formed by an optimized thermally induced crosslinking route, initiated by the presence of ammonium persulfate, whereas the macroporosity was created through a cryogenic technique. Crosslinking stabilizes the three dimensional (3D) gel structure, allowing the replacement of expensive and time‐consuming lyophilization steps in favor of simpler drying procedures at atmospheric pressure. The in‐situ formation of iron oxide NPs (IONPs) was achieved through oxide precursors impregnation followed by precipitation of the IONPs in the highly swellable hydrogels. This reaction was performed by addressing two strategies, namely, before or after cryogenic processing, to evaluate its effect on the final swelling and adsorption properties of the gel matrices. It is demonstrated that the inclusion of the magnetic NPs before cryo‐structuring allows the stabilization of the gel against collapse, favoring the conservation of a highly swellable environment. The synergy between the adsorption capacity of the IONPs and the high swelling of the macroporous structure allows obtaining materials with potential in adsorption processes. Preliminary analyses showed that macroporous samples obtained with 32 wt% IONPs led to methylene blue (MB) adsorption capacities as high as 400 mg dye/g ferrogel, for dye concentrations as low as 10 mg/L. These results show that the use of an adequate strategy for the processing of macroporous ferrogels can be of high importance in the design of new adsorbents and superabsorbent hydrogels.
Anatomic donor surgeries increase self‐efficacy in physical therapy education: Use of live versus recorded viewing
Authors: Friel Karen J. , Shultz S. Tyler 
Published: July 2023

AbstractAnatomy serves as a foundational course in physical therapy education, but, due to its early placement in the curriculum, may have limited clinical application at that point of a student's education. Thus, augmenting a standard dissection course with surgical procedures can enhance the clinical relevance and knowledge of the anatomical structures involved in those surgeries. Doctor of Physical Therapy students viewed a variety of cadaveric orthopedic and cardiothoracic surgeries performed by a surgeon. Students unable to participate live viewed the recorded surgeries. Participants completed a 10‐point Likert scale survey, developed by the researchers, pre‐ and post‐viewing, on self‐efficacy of knowledge, patient intervention and communication. Data analysis revealed improved self‐efficacy of knowledge of the anatomy and the surgical procedures, confidence in treating patients undergoing those surgeries, and confidence communicating with surgeons, regardless of whether students viewed the surgeries live or recorded. Students participating in this experience expressed a clear value enhancement on their education. Programs should feel confident that this type of experience in the curriculum, whether live or recorded, will have a positive effect on student self‐efficacy as related to the relationships and pertinence of anatomical structures involved in the surgeries, the surgical procedures, treating patients having undergone those surgeries, and interprofessional communication.
Recent Progress in Asymmetric Domino Intramolecular Cyclization/Cascade Reactions of Substituted Olefins
Authors: Zou Liang , Gao Yuan , Zhang Qiaoman , Ye Xiang‐Yang , Xie Tian , Wang Li‐Wei , Ye Yang 
Published: July 2023

AbstractThe domino cyclization/coupling strategy is one of the most effective methods to produce cyclized and multi‐functionalized compounds from olefins, which has attracted huge attention from chemists and biochemists especially for its considerable potential of enantiocontrol. Nowadays, more and more studies are developed to achieve difunctionalization of substituted olefins through an asymmetric domino intramolecular cyclization/cascade reaction, which is still an elegant choice to accomplish several synthetic ideas such as complex natural products and drugs. This review surveys the recent advances in this field through reaction type classification. It might serve as useful knowledge desktop for the community and accelerate their research.
Vision outcomes in children with fetal alcohol spectrum disorders
Authors: Lyubasyuk Vera , Jones Kenneth Lyons , Caesar Michelle Ann , Chambers Christina 
Published: July 2023

AbstractBackgroundPrevious studies demonstrated that children with Fetal Alcohol Spectrum Disorders (FASD) are more likely to have vision impairments. However, existing human clinical and epidemiological investigations are few and include limited sample sizes. This study aimed to explore the association between ophthalmologic abnormalities and FASD in a sample of 5–7 year old children in the general population.MethodsThis was a cross‐sectional study nested in a larger study intended to estimate the prevalence of FASD in San Diego, California, conducted between 2012 and 2014. Prenatal exposure to alcohol, dysmorphology examinations, and a neurobehavioral testing battery were collected for each child and an FASD diagnosis was assigned. Parents of participating children were asked to release their child's vision screening or diagnostic records.ResultsVision records were obtained for 424 participants in the larger prevalence study. Of these, 53 children were classified as having FASD. A statistically significant association was found between FASD and a diagnosis of strabismus; 5/42 (11.9%) of children who were classified as having FASD had strabismus compared to 6/290 (2.1%) of children who were not classified as having FASD (p = .01). All five cases of strabismus in the FASD group occurred in 19 children classified as having partial fetal alcohol syndrome (pFAS). No association was found between FASD and vision impairment (p = .23), refractive errors (p = .66), glasses/contact lens prescription (p = .30), or having one or more ophthalmological abnormalities (p = .97).ConclusionsAn association between strabismus and FASD, specifically partial FAS, suggests that the effect of alcohol exposure on risk of strabismus must be severe enough to result in facial features consistent with FASD. This emphasizes the importance of vision screening in children with FASD.
Hydrogen Peroxide‐Inducible PROTACs for Targeted Protein Degradation in Cancer Cells
Authors: Yu Dehao , Fan Heli , Zhou Zhili , Zhang Ying , Sun Jing , Wang Luo , Jia Yuanyuan , Tian Junyu , Campbell Anahit , Mi Wenyi , Sun Huabing 
Published: July 2023

AbstractProteolysis‐targeting chimeras (PROTACs) provide a powerful technique to degrade targeted proteins utilizing the cellular ubiquitin‐proteasome system. The major concern is the host toxicity resulting from their poor selectivity. Inducible PROTACs responding to exogenous stimulus, such as light, improve their specificity, but it is difficult for photo‐activation in deep tissues. Herein, we develop H2O2‐inducible PROTAC precursors 2/5, which can be activated by endogenous H2O2 in cancer cells to release the active PROTACs 1/4 to effectively degrade targeted proteins. This results in the intended cytotoxicity towards cancer cells while targeted protein in normal cells remains almost unaffected. The higher Bromodomain‐containing protein 4 (BRD4) degradation activity and cytotoxicity of 2 towards cancer cells is mainly due to the higher endogenous concentration of H2O2 in cancer cells (A549 and H1299), characterized by H2O2‐responsive fluorescence probe 3. Western blot assays and cytotoxicity experiments demonstrate that 2 degrades BRD4 more effectively and is more cytotoxic in H2O2‐rich cancer cells than in H2O2‐deficient normal cells. This method is also extended to estrogen receptor (ER)‐PROTAC precursor 5, showing H2O2‐dependent ER degradation ability. Thus, we establish a novel strategy to induce targeted protein degradation in a H2O2‐dependent way, which has the potential to improve the selectivity of PROTACs.
New presentation of CLIFAHDD syndrome with a novel variant in NALCN gene: A report of a rare case
Authors: Hashemi Bita , Huntsman Richard J. , Li Huan , Zhang Dapeng , Xi Yanwei 
Published: July 2023

Key Clinical MessageCongenital Contractures of Limbs and Face, Hypotonia, and Developmental Delay (CLIFAHDD) syndrome is a recently described type of distal arthrogryposis which unlike other subtypes is associated with developmental delay and various neurologic presentation. Epilepsy and ataxia have been reported. We add paroxysmal dyskinesia to the clinical spectrum. Understanding the molecular mechanism can help developing targeted therapy in future.AbstractThis study resulted in identification of a novel variant in NALCN gene leading to autosomal dominant CLIFAHDD syndrome. Our patient presented with a form of nonepileptic paroxysmal dyskinesia. This is a new phenotype that has not been described previously.