bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two Phase Relative Permeability Curve Upscaling of Naturally Fractured Reservoirs Under Poro-Elastic Environment
Authors: Abdel Azim Reda Rabiee , Hamada Ghareb , Al Jehani Abdurrahman 
Published: March 2023

AbstractThe target of upscaling is to replace the very fine and detailed models with coarse models, including much less data. These coarse models are more feasible for running simulations than the fine models. However, upscaling does not aim to speed up reservoir simulations at the cost of simulation results. This study presents an innovative approach to upscale the two-phase core relative permeability to reservoir grid block scale under poro-elastic framework for fractured basement reservoirs using glass bead laboratory measurements and finite element technique. This approach uses a hybrid methodology to calculate grid block equivalent permeability tensors by combining the discrete fracture network and single permeability approaches. The first step in the workflow of upscaling the core relative permeability curve is dividing the reservoir into a number of grid blocks (20 m × 20 m × 30 m) and then the individual grid block is divided into laboratory glass bead model scale of (20 cm × 10 m × 2 cm) to enhance the upscaling process. Next, the new generated kr curves ( Fahad et al. 2013) correlation bas ed on glass bead scale is is used to upscale the laboratory relative permeability curve to each fine-scale grid. The Levenberg-Marquardt inversion algorithm is used during the simulation process of the relative permeability upscaling to match produced oil recovery before and after upscaling. The results illustrate that the upscaling kr curves process is strongly affected applied stresses, fracture orientation and connectivity.
New Dissolvable Isolation Tool Eliminating Plug and Perf Operation Challenges and Reduce Completion Costs
Authors: Wang Jinlu , He Xusheng , Wang Junyuan , Xiao Fengfeng , Liu Qi , Zhang Longlong , Chen Haili 
Published: March 2023

Abstract
In recent years, operators have reported that dissolvable frac plugs have made completions more time-consuming and costly in many cases. Poorly designed dissolvable frac plugs can cause problems such as early failure and skidding under pressure when they dissolve too early.
On the other hand, if dissolvable frac plugs do not dissolve completely, it can lead to extended post-intervention time. Drilling out a composite frac plug typically takes 2-15 minutes, while removing a dissolvable frac plug that hasn't dissolved fully can take up to an hour or even longer due to the material structure not being designed for quick drilling.
Additionally, when undissolved frac plugs are pushed towards the bottom of the well, they can create a pack-off on the way, which increases drill-out time. This is a common issue in low temperature and low salinity environments because temperature and salinity are two key factors that influence the dissolving process of dissolvable frac plugs.
Based on our experiences, dissolvable technology can be both beneficial and challenging. To customize products that are suitable for different conditions, expertise and a thorough understanding of both application and engineering are necessary. The tool supplier must consider all operational details, including the conditions and requirements, to design, simulate, validate, and optimize the product in order to achieve optimal performance and results for end users. This requires a careful balance between tool performance and dissolvability.
Evaluating diagnostic and management agreement between physiotherapists and ear, nose and throat specialist in a primary contact physiotherapy-led vestibular clinic: A prospective blinded inter-rater agreement study
Authors: Stewart Vicky , Eakin Jennifer , Weir Kelly , Noonan Fritha , Payten Christopher , Smith Tamsin 
Published: March 2023

Abstract

Background: Dizziness and vertigo are common referrals to Ear Nose Throat (ENT) outpatient services however these services have long waitlists for assessment. While a primary contact physiotherapy-led vestibular clinics is recognized at improving access to care, no published literature has reported on the safety and diagnostic accuracy of such a service. This study investigates diagnostic and management agreement between physiotherapists and ENT specialist for patients attending a primary contact physiotherapy-led vestibular clinic.
Methods: Prospective blinded inter-rater agreement study undertaken in an ENT primary contact physiotherapy-led vestibular clinic. Participants included adults referred to ENT from general practitioners, triaged (Category 2 or 3) to the primary contact physiotherapy-led vestibular clinic with clinical symptoms consistent with vestibular disorder. Primary outcome measures included diagnoses and management decisions (imaging, ENT/ neurology/ physiotherapy management). Adverse events were reviewed 11 months post data collection. Percentage agreement and Gwet’s first order agreement co-efficient (AC1) calculated inter-rater reliability between physiotherapy and ENT.
Results: Fifty-one participants were recruited consecutively from the primary contact physiotherapy-led vestibular clinic. Physiotherapy and ENT had a 78% agreement on categorised diagnosis. Agreements between physiotherapy and ENT for recommending Magnetic resonance imaging was 86%, and 94% for computorised tomography. There was moderate to near-perfect agreement regarding management recommendations between physiotherapy and ENT. An 82% agreement was found for recommendations to ENT, 94% for neurology and 73% for physiotherapy. There were no adverse events from physiotherapist’s management decision, based on final recommendations undertaken 11-months post data collection.
Conclusions: Physiotherapists and ENT made comparable diagnostic and management decisions, based on physiotherapy assessment, for adults with signs of vestibular dysfunction, within an ENT primary contact physiotherapy-led vestibular clinic. This provides reassurance about the competency and safety of vestibular physiotherapists in the management of patients with dizziness.
Prepulse Inhibition Deficit as a Transdiagnostic Process in Neuropsychiatric Disorders: A Systematic Review
Authors: Santos-Carrasco Daniel , Casa Luis Gonzalo De la 
Published: March 2023

Abstract

Psychopathological research is moving from a specific approach towards transdiagnosis through the analysis of processes that appear transversally to multiple pathologies. A phenomenon disrupted in several disorders is prepulse inhibition (PPI) of the startle response, in which startle to an intense sensory stimulus, or pulse, is reduced if a weak stimulus, or prepulse, is previously presented. The present systematic review analyzed the role of PPI deficit as a possible transdiagnostic process for three main groups of neuropsychiatric disorders: 1) trauma-, stress-, and anxiety-related disorders 2) mood-related disorders, and 3) neurocognitive disorders. We used Web of Science, Pubmed and PsycInfo databases to search for experimental case-control articles that were analyzed both bibliometrically and based on their potential risk of bias. A total of 41 studies were included in this systematic review. The results showed a general PPI deficit in the three diagnostic groups mentioned, with associated deficits in the dopaminergic neurotransmission system, several areas implied such as the medial prefrontal cortex or the amygdala, and related variables such as cognitive deficits and anxiety symptoms. It can be concluded that the PPI deficit is a transdiagnostic process across most of the neuropsychiatric disorders examined, and it is a relevant measure in translational research for the early detection and intervention of such disorders. Protocol submitted prospectively to PROSPERO 04/30/2022 (CRD42022322031).
Impact of initial dialysis modality on the survival of patients with ESRD: A propensity-score-matched study
Authors: Liu Li , Pang Jie , Xu Juan , Liu Lin-na , Liao Man-yu , Huang Qing-xiu , Li Yan-lin 
Published: March 2023

Abstract
Background
Studies comparing survival of hemodialysis (HD) and peritoneal dialysis (PD) patients are controversial. This study evaluated the impact of initial dialysis modality on the survival of patients with end-stage renal disease (ESRD) in a matched-pair cohort.
Methods
A retrospective cohort study was performed on ESRD patients who initiated renal replacement treatment between January 1, 2010, and December 31, 2018. Propensity score matching was applied to balance the baseline conditions, and multivariate Cox regression analysis was applied to compare mortality between HD and PD patients and evaluate correlations between mortality and various baseline characteristics. Subgroup analysis was performed with respect to diabetes status.
Results
There were 739 patients in our center in the Chinese National Renal Data System (CNRDS) between 2010 and 2018. Of these, 125 PD patients were matched with 125 HD patients. The 1-, 2-, and 3-year survival rates were 96.5%, 90.7%, and 82.5%, respectively, in the HD group and 99.5%, 97.8%, and 92.5%, respectively, in the PD group (log-rank P < 0.001). Among the propensity score-matched cohorts, no significant differences in Kaplan–Meier curves were observed between the two groups (log-rank P = 0.514). Age at dialysis initiation, CCI, congestive heart failure and cerebrovascular disease were risk factors in the multivariable-adjusted model. In subgroups defined by diabetes status, the Kaplan‒Meier survival curve showed that PD survival was significantly higher than that of HD (log-rank P = 0.022).
Conclusions
HD and PD were not significantly different with regard to survival of patients with ESRD. PD was associated with better survival in diabetic ESRD patients.
Clinical value of simultaneous boost intensity modulated radiotherapy in high-risk clinical target volume of stage IIb-IVa cervical carcinoma
Authors: jiang yuqi , Zhang Lei , Wang Jing , Jiang Peng , Wang Xiang , Zhang Yongchun 
Published: March 2023

Abstract
Background
To compare the clinical efficacy of simultaneous modulated accelerated radiotherapy therapy to high-risk clinical volume (CTV-hr) with conventional intensity modulated radiotherapy therapy for stage IIB-IVA cervical cancer, and investigate the value of defining high-risk clinical target areas for parallel radiation dose simultaneous nudging in patients with locally advanced cervical cancer.
Methods
Retrospectively analyzed patients with stage IIB-IVA cervical cancer who received radical radiotherapy at the Affiliated Hospital of Qingdao University from November 2014 to September 2019, divided into hr-SMART group and n- SMART group according to whether to set a high-risk clinical target volume(CTV-hr) and push the volume to 54–56 Gy simultaneously. Both groups were given brachytherapy and chemotherapy and compared the efficacy and adverse effects.
Results
A total of 217 patients were assessed, with 119 and 98 in the hr-SMART and n-SMART groups. Hr-SMART and n-SMART groups had significantly different mortality rate(19.3% vs 41.8%), overall recurrence rates (26.1% vs 50%) with statistically significant differences (p < 0.05). According to the KM survival curve, hr-SMART has a better OS (3-year OS rate, 87.4% vs. 71.4% ; P = 0.001) and PFS (3-year OS rate, 72.3% vs. 51.0% ; P = 0.000)than n-SMART.The objective remission rates (ORR) in the hr-SMART and n-mart groups were 91.6% and 90.8%, respectively, with no statistically significant differences (p༞0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (p > 0.05).
Conclusions
Setting up high-risk clinical target volume and undergoing simultaneous modulated accelerated radiotherapy for patients with stage IIB-IVA cervical cancer can reduce recurrence and improve clinical efficacy with comparable adverse effects.
Genetic diversity and population structure of selected species of Eplingiella (Lamiaceae) using ISSR molecular markers
Authors: Silva Anderson de Carvalho , de Oliveira Lenaldo Muniz , Pastore José Floriano Barêa , Berg Cassio van den , Soares Taliane Leila , de Souza Everton Hilo 
Published: March 2023

Abstract

The present study evaluated the population structure and genetic diversity using ISSR molecular markers in 18 natural populations belonging to three species ofEplingiella(E. cuniloides, E. fruticosaandE. brightoniae), found growing naturally in the semiarid region of Northeast Brazil. Samples of 265 plants were analyzed using nine primer combinations, which generated 131 informative bands.Eplingiellaspp. populations showed moderate genetic diversity (percentage of polymorphic bands, PPB = 75.6–96.9%, Nei's genetic diversityHe = 0.31–0.39, Shannon's information indexI = 0.33–0.48). Molecular variance analysis (AMOVA) revealed that within populations, variations contributed more (74%) to the genetic diversity than between population variations (26%), with percentage of the genetic differentiation coefficient (GST= 0.29). The mean value ofFSTwas 0.175, demonstrating good differentiation between populations. The analysis of the structure by the Bayesian method revealed the formation of two groups (K = 2), with many migrant individuals and a high level of miscegenation. The hierarchical cluster dendrogram grouped the 18 populations into two major clusters, with good support for the main clades (100%). According to principal component analysis (PCA), the two main principal components explained 21.06% of the total variation. The ISSR molecular markers used were effective in identifying the variability of natural populations ofEplingiellaspp., and population structure demonstrated recent diversification of species. The results shed more light on the genetic variation and evolutionary dynamics ofEplingiella, helping to formulate effective breeding strategies.
Salidroside regulates tumor microenvironment of non-small cell lung cancer via Hsp70/Stub1/Foxp3 pathway in Tregs
Authors: Wen Zexin , Liu tong , Zhang Yanli , Yue Qiujuan , Meng Hang , He Yijie , Yang Yi , Li Minghao , Zheng Jianwen , Lin Wei 
Published: March 2023

Abstract

Background:The treatment of non-small cell lung cancer (NSCLC) is challenging due to immune tolerance and evasion. Salidroside (SAL) is an extract in traditional Chinese medicine and has a potential antitumor effect. However, the mechanism of SAL in regulating the immunological microenvironment of NSCLC is yet to be clarified.Methods:The mouse model with Lewis lung cancer cell line (3LL) in C57BL/6 mice was established. And then, the percentage of tumor-infiltrating T cell subsets including Treg was detected in tumor-bearing mice with or without SAL treatment.In vitro, the effect of SAL on the expression of IL-10, Foxp3 and Stub1 and the function of Treg were detected by flow cytometry. Network pharmacology prediction and molecular docking software were used to predict the target of SAL and intermolecular interaction. Furthermore, the effect of SAL on the expression of Hsp70 and the co-localization of Stub1-Foxp3 in Treg was confirmed by flow cytometry and confocal laser microscopy. Finally, Hsp70 inhibitor was used to verify the above molecular expression.Results:We discovered that SAL treatment inhibits the growth of tumor cells by decreasing the percentage of tumor-infiltrated CD4+Foxp3+T cells. SAL treatment downregulates the expression of Foxp3 in Tregs, but increases the expression of Stub1, an E3 ubiquitination ligase upstream of Foxp3, and the expression of Hsp70. Inhibiting the expression of Hsp70 reverses the inhibition of SAL on Foxp3 and disrupts the colocalization of Stub1 and Foxp3 in the nucleus of Tregs.Conclusions:SAL inhibits tumor growth by regulating the Hsp70/stub1/Foxp3 pathway in Treg to suppress the function of Treg. It is a new mechanism of SAL for antitumor therapy.
WITHDRAWN: The Impact of Training and Technological Innovation on Early Childhood Development under a National Home-Visiting Programme in Ecuador: study protocol for a cluster-randomised trial
Authors: Conti Gabriella , Gupta Sweta , Hill Zelee , Jervis Pamela , Paredes Tatiana 
Published: March 2023

Abstract
Background
This study aims to document the effect of teacher training, technology-enabled monitoring, information and motivational nudges in a national home-visiting programme on early childhood development in Ecuador.
Methods
The study is a 2-arm, cluster randomized controlled trial with parallel assignment and an active control group. The clusters are 48 catchment areas (districts) in the Sierra (Highlands) region of Ecuador, and all home-visiting teachers, district analysts, and children in the selected districts are included in the study. In addition, a random sample of 34 children and their biological mothers or caregivers per district will be selected for evaluation of outcomes. The primary outcome measures are: (1) pre-literacy and pre-numeracy skills as measured by the IDELA (2) executive functioning as measured by the IDELA and the Delay Choice Task (3) language development as measured by the TVIP and (4) Child Development (caregiver report) as measured by ECDI.
Discussion
Several small-scale home-visiting trials, targeting undernourished children in developing countries, have shown impacts on early childhood development in the short run. But the important question remains as to whether such results can be achieved at scale. If the intervention under this study is found to be effective at improving child development, it would have important implications for low and middle-income countries where 250 million children under the age of five are at risk of not reaching their full development potential. The intervention is integrated into an existing nation-wide home-visiting programme in Ecuador and involves training existing staff alongside upgrading the digital infrastructure, thus representing a feasible strategy for large-scale implementation.
Trial Registration Number:
ISRCTN16602033. Registered on 14 January 2023, https://www.isrctn.com/ISRCTN16602033.
Positional cloning and functional verification of the epidermal protein gene KWMTBOMO04384 in silkworm, Bombyx mori
Authors: Sun Juan , Liu Min , Zheng Xin , Ouyang Gui , Qian Heying , Chen Anli 
Published: March 2023

Abstract
A body shape mutant n08M with sunken intersegmental membrane was found during the feeding process of silkworm WT-n08. Genetic analysis showed that the mutant trait of n08M is controlled by a recessive gene located at the autosome and follows Mendelian inheritance. Results of positional cloning showed that the epidermal protein gene KWMTBOMO04384 on chromosome 26 was mutated. After KWMTBOMO04384 was knocked out by CRISPR/Cas9, the intersegmental membrane of silkworm was sunken. KWMTBOMO04384 was the target gene that caused the sunken intersegmental membrane in WT-n08 and had an important influence on the body shape of Bombyx mori.
The Clinical Utility of salivary oxytocin as a putatively surrogate early Risk Identification biomarker of nascent Metabolic Syndrome with and without prediabetes
Authors: Bulatova Nailya R. , Kasabri Violet N. , Albsoul Abla M. , Halaseh Lana , Suyagh Maysa 
Published: March 2023

Abstract
Aims and methods This study aimed to compare and correlate pharmacotherapy biomarkers’ plasma and salivary levels (appraised using colorimetric assays of Lipocalin, Nesfatin, Omentin, Oxytocin, RBP-4 (retinol-binding protein-4), Resistin, SIRT 1 (sirtuin 1), Visfatin and ZBED3 (zinc finger, BED-type (ZBED) protein 3), adiposity, and atherogenicity indices in 61 normoglycemic and newly diagnosed drug naive pre-diabetic (PreDM) MetS (metabolic syndrome) patients vs. 29 lean, and normoglycemic controls. Intergroup Comparisons was conducted by ANOVA. Spearman rank correlation was also examined.
Results About three quarters of the participants were females, with gender distribution similar between the two study groups (P = 0.585). Among MetS patients, almost half were normoglycemic, about 43% were prediabetic and about 8% were diabetic. The average age of study participants was 48.6 years, with MetS group being significantly older than the control group (P < 0.001). In accordance to the study selection criteria, glycemic (FPG and A1c) and lipid parameters (TG, HDL-C and non-HDL-C), adiposity indices (BMI, WHR, WtHR, C-index, BAI, LAP, VAI) and atherogenicity indices (AIP, TC/HDL-C, LDL-C/HDL-C, non-HDL-C/HDL-C and TG/HDL-C) were all significantly higher in the MetS group compared to the control group (P < 0.05). Among the plasma cardiometabolic risk biomarkers of pharmacotherapy, plasma (but not salivary) lipocalin levels and Salivary nesfatin (unlike plasma nesfatin) were significantly higher P < 0.05) in the MetS group compared to the normoglycemic lean controls. Notably, plasma SIRT1 levels were pronouncedly greater (P < 0.05) in MetS recruits in comparison to control’s levels. Conversely; salivary SIRT1 concentrations in MetS pool markedly exceeded those of controls’ salivary levels. Oddly and collectively salivary and blood levels of omentin, oxytocin, RBP-4, resistin, visfatin and ZBED3 lacked comparably pronounced discrepancies in MetS cases vs. those of study controls. Exceptionally oxytocin, amongst 9 cardiometabolic risk biomarkers of pharmacotherapy studied, had proportional significant correlations between plasma and saliva levels, in both total sample and MetS patients (P < 0.05). Plasma OXT in the total sample correlated significantly though inversely with both SBP and FBG (unlike salivary OXT). Interestingly of MetS pool; markedly Proportional correlations of plasma (but not salivary) OXT with TG, and adiposity indices of LAP and VAI, and all atherogenecity indices were delineated. Collectively both blood and saliva OXT in the total study pool, as well as the remaining biomarkers; lacked comparably substantial associations with both adiposity and atherogenecity indices and clinical parameters of fasting lipid profile.
Expression of secretory calcium-binding phosphoprotein (scpp) genes in medaka during the formation and replacement of pharyngeal teeth
Authors: Morita Tsuyoshi , Matsumoto Shin , Baba Otto 
Published: March 2023

Abstract
Background
Analyses of tooth families and tooth-forming units in medaka with regard to tooth replacement cycles and the localization of odontogenic stem cell niches in the pharyngeal dentition clearly indicate that continuous tooth replacement is maintained. The secretory calcium-binding phosphoprotein (SCPP) cluster is involved in the formation of mineralized tissues, such as dental and bone tissues, and the genes encoding multiple SCPPs are conserved in fish, amphibians, reptiles, and mammals. In the present study, we examined the expression patterns of several scpp genes in the pharyngeal teeth of medaka to elucidate their roles during tooth formation and replacement.
Methods
Himedaka (Japanese medaka, Oryzias latipes) of both sexes (body length: 28 to 33 mm) were used in this study. Real-time reverse transcription–polymerase chain reaction (PCR) (qPCR) data were evaluated using one-way analysis of variance for multi-group comparisons, and the significance of differences was determined by Tukey’s comparison test. The expression of scppgenes was examined using in situhybridization (ISH) with a digoxigenin-labeled, single-stranded antisense probe.
Results
qPCR results showed that several scpp genes were strongly expressed in pharyngeal tissues. ISH analysis revealed specific expression of scpp1, scpp5, and sparc in tooth germ, and scpp5 was continually expressed in the odontoblasts of functional teeth but not in osteoblast of pedicles. In addition, many scpp genes were expressed in enameloid cells but not in odontoblasts, and scpp2 consistently showed epithelial-specific expression in the functional teeth. Taken together, these data indicate that specific expression of scpp2 and scpp5 may play a critical role in pharyngeal tooth formation in medaka.
Conclusion
We characterized changes in the expression patterns of scpp genes in medaka during the formation and replacement of pharyngeal teeth.