bluuebunny/crossref_metadata_2025_split huggingface dataset:
Permafrost preservation reveals proteomic evidence for yak milk consumption in the 13th century
Authors: Ventresca Miller Alicia R. , Wilkin Shevan , Bayarsaikhan Jamsranjav , Ramsøe Abigail , Clark Julia , Byambadorj Batsuren , Vanderwarf Sandra , Vanwezer Nils , Haruda Ashleigh , Fernandes Ricardo , Miller Bryan , Boivin Nicole 
Published: April 2023

AbstractDomesticated yaks endure as iconic symbols of high-altitude frozen landscapes, where herding communities depend on their high-fat milk, transport, dung, and natural fibers. While there is established proteomic evidence for ancient consumption of ruminant and horse milk in the mountains and steppes of northern Eurasia, yak dairy products have yet to be detected. Yak domestication and the species’ dispersal from Tibet into the mountainous zones to the north are also poorly resolved due to a paucity of zooarchaeological data. To examine the potential of paleoproteomics to shed light on domesticated yak in Mongolia, we analyzed human dental calculus from Mongol era elite individuals recovered from permafrost burials in Khovsgol province, where people continue to herd yak to this day. We report the first evidence for yak dairy consumption, linked to local resource control. In addition, we confirm a large diversity of recovered whey, curd, tissue, and blood proteins, likely reflecting the excellent preservation conditions found at permafrost sites.
Selective sorption of oxygen and nitrous oxide by an electron donor-incorporated flexible coordination network
Authors: Shivanna Mohana , Zheng Jia-Jia , Ray Keith G. , lto Sho , Ashitani Hirotaka , Kubota Yoshiki , Kawaguchi Shogo , Stavila Vitalie , Yao Ming-Shui , Fujikawa Takao , Otake Ken-ichi , Kitagawa Susumu 
Published: April 2023

AbstractIncorporating strong electron donor functionality into flexible coordination networks is intriguing for sorption applications due to a built-in mechanism for electron-withdrawing guests. Here we report a 2D flexible porous coordination network, [Ni2(4,4′-bipyridine)(VTTF)2]n(1) (where H2VTTF = 2,2′-[1,2-bis(4-benzoic acid)-1,2ethanediylidene]bis-1,3-benzodithiole), which exhibits large structural deformation from the as-synthesized or open phase (1α) into the closed phase (1β) after guest removal, as demonstrated by X-ray and electron diffraction. Interestingly, upon exposure to electron-withdrawing species, 1β reversibly undergoes guest accommodation transitions; 1α⊃O2 (90 K) and 1α⊃N2O (185 K). Moreover, the 1β phase showed exclusive O2 sorption over other gases (N2, Ar, and CO) at 120 K. The phase transformations between the 1α and 1β phases under these gases were carefully investigated by in-situ X-ray diffraction, in-situ spectroscopic studies, and DFT calculations, validating that the unusual sorption was attributed to the combination of flexible frameworks and VTTF (electron-donor) that induces strong interactions with electron-withdrawing species.
Pregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma
Authors: Gomez-Lopez Nardhy , Romero Roberto , Escobar María Fernanda , Carvajal Javier Andres , Echavarria Maria Paula , Albornoz Ludwig L. , Nasner Daniela , Miller Derek , Gallo Dahiana M. , Galaz Jose , Arenas-Hernandez Marcia , Bhatti Gaurav , Done Bogdan , Zambrano Maria Andrea , Ramos Isabella , Fernandez Paula Andrea , Posada Leandro , Chaiworapongsa Tinnakorn , Jung Eunjung , Garcia-Flores Valeria , Suksai Manaphat , Gotsch Francesca , Bosco Mariachiara , Than Nandor Gabor , Tarca Adi L. 
Published: April 2023

AbstractBackgroundPregnant women are at greater risk of adverse outcomes, including mortality, as well as obstetrical complications resulting from COVID-19. However, pregnancy-specific changes that underlie such worsened outcomes remain unclear.MethodsPlasma samples were collected from pregnant women and non-pregnant individuals (male and female) with (n = 72 pregnant, 52 non-pregnant) and without (n = 29 pregnant, 41 non-pregnant) COVID-19. COVID-19 patients were grouped as asymptomatic, mild, moderate, severe, or critically ill according to NIH classifications. Proteomic profiling of 7,288 analytes corresponding to 6,596 unique protein targets was performed using the SOMAmer platform.ResultsHerein, we profile the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls and show alterations that display a dose-response relationship with disease severity; yet, such proteomic perturbations are dampened during pregnancy. In both pregnant and non-pregnant state, the proteome response induced by COVID-19 shows enrichment of mediators implicated in cytokine storm, endothelial dysfunction, and angiogenesis. Shared and pregnancy-specific proteomic changes are identified: pregnant women display a tailored response that may protect the conceptus from heightened inflammation, while non-pregnant individuals display a stronger response to repel infection. Furthermore, the plasma proteome can accurately identify COVID-19 patients, even when asymptomatic or with mild symptoms.ConclusionThis study represents the most comprehensive characterization of the plasma proteome of pregnant and non-pregnant COVID-19 patients. Our findings emphasize the distinct immune modulation between the non-pregnant and pregnant states, providing insight into the pathogenesis of COVID-19 as well as a potential explanation for the more severe outcomes observed in pregnant women.
Fluorescence quenching determination of tetracyclines based on the synergistic oxidation effect between Fe3O4 nanoparticles and tetracyclines
Authors: Guo Shiqi , Chai Yilin , Wu Yongjun , Guo Hongchao , Yu Fei , Liu Li-e , He Leiliang , Yu Songcheng , Tian Yongmei , Wang Jia , Yang Ruiying , Jian Ningge , Wang Yilin 
Published: April 2023

Abstract
In recent years, tetracyclines (TCs) is a hot research topic. Herein, we report an interesting discovery using the complexation of oxytetracycline and metal ions. In this study, according to the properties of Fe3O4 nanoparticles (Fe3O4 NPs) as a nanoenzyme, it can be used to catalyze the oxidation of KI by H2O2 to produce

I

3

−

,

while at the same time

I

3

−

binds to rhodamine 6G (Rh6G) to form a conjoined particle (Rh6G ∼ I3)n, leading to a decrease in the fluorescence intensity of Rh6G. However, in the presence of TCs, Fe3O4 NPs have a synergistic effect with TCs, leading to enhanced catalytic activity, as well as better selectivity compared to the activity of other reducing enzymes. Consequently,the fluorescent signal based on a resonance scattering effect between Rh6G and

I

3

−

is dependent on the concentration of TCs, thus achieving highly facile and robust detection of TCs. The limits of detection (LOD) of the method were 20 nM, 10 nM and 40 nM for oxytetracycline(OTC), tetracycline(TC) and chlortetracycline(CTC), respectively. Most importantly, the method can be successfully applied to the detection of TCs in milk, eggs, and honey. The recoveries of spiked samples ranged from 83.11 to 118.95%. Thus, a stable, hands-on strategy for the detection of TCs is proposed, which has potential applications in the field of food safety and environmental protection.
Magnetic glassy state in combination with ferromagnetism in Fe0.05(SnTe)0.97Sb0.03 bulk alloy
Authors: Menon Sitara , Sarkar Mitesh , Singh Satyendra , Venkatesh R 
Published: April 2023

Abstract
In this study on Fe0.05(SnTe)0.97Sb0.03 bulk alloy, we found signatures of presence of both magnetic glassy state and ferromagnetism. The bulk alloy is prepared by modified solid state technique and the sample is characterized for its structural, electrical and magnetic properties. Electrical resistivity plot shows semiconducting nature of the sample, however below 25 K, a sudden increase in the electrical resistivity value is observed. The transport mechanism is explained on the basis of small polaron hopping (SPH) model and variable range hopping (VRH) model. A large bifurcation observed between zero-field cooled and field-cooled magnetization at low temperature hints towards existence of a magnetic glassy state. M-H curve exhibits hysteresis behaviour for the measurements carried out at 10, 100 and 300 K. However, absence of saturation of the curves at 10 and 100 K suggests co-existence of ferromagnetic and glassy state. Presence of magnetic glassy state can also be confirmed from the Arrott plot and AC Susceptibility measurement. The susceptibility curves are found to undergo relatively small shift of peaks with frequency and theoretical fitting of the data supports presence of a cluster-glass state.
The possibility of anesthesia stimulated by a train of current pulses
Authors: Shneider Mikhail N , Pekker Mikhail 
Published: April 2023

Abstract
This study considers a simple theoretical model of blocking the passage of signals (action potentials) from sensory neurons, thereby affecting anesthesia without the use of anesthetics as a result of a sequence of unipolar current pulses generated by an external source. The proposed model allows the selection of parameters and the required frequency of the repetition of current pulses for the possible implementation of anesthesia, depending on the electrical characteristics of the skin and the conductivity of the saline solution in which the myelinated nerve fibers are located.
Heating and lighting: understanding overlooked energy-consumption activities in the Indian residential sector
Authors: Navinya Chimurkar , Kapoor Taveen S , Anurag Gupta , Lokhande Pradnya , Sharma Renuka , Prasad SV Laxmi , Nagendra SM Shiva , Kumari Jyoti , Habib Gazala , Arya Rahul , Mandal Tuhin K , Muthalagu Akila , Qureshi Asif , Najar Tanveer Ahmad , Jehangir Arshid , Jain Supreme , Goel Anubha , Rabha Shahadev , Saikia Binoy K , Chaudhary Pooja , Sinha Baerbel , Haswani Diksha , Raman Ramya Sunder , Dhandapani Abisheg , Iqbal Jawed , Mukherjee Sauryadeep , Chatterjee Abhijit , Lian Yang , Pandithurai G , Venkataraman Chandra , Phuleria Harish C 
Published: April 2023

Abstract
Understanding the climate impact of residential emissions starts with determining the fuel consumption of various household activities. While cooking emissions have been widely studied, non-cooking energy-consumption activities in the residential sector such as heating and lighting, have been overlooked owing to the unavailability of data at national levels. The present study uses data from the Carbonaceous Aerosol Emissions, Source Apportionment and Climate Impacts (COALESCE) project, which consists of residential surveys over 6000 households across 49 districts of India, to understand the energy consumed by non-cooking residential activities. Regression models are developed to estimate information in non-surveyed districts using demographic, housing, and meteorological data as predictors. Energy demand is further quantified and distributed nationally at a 4 × 4 km resolution. Results show that the annual energy consumption from non-cooking activities is 1106 [201] PJ, which is equal to one-fourth of the cooking energy demand. Freely available biomass is widely used to heat water on traditional stoves, even in the warmer regions of western and southern India across all seasons. Space heating (51%) and water heating (42%) dominate non-cooking energy consumption. In comparison, nighttime heating for security personnel (5%), partly-residential personal heating by guards, dominant in urban centers and kerosene lighting (2%) utilize minimal energy. Biomass fuels account for over 90% of the non-cooking consumption, while charcoal and kerosene make up the rest. Half of the energy consumption occurs during winter months (DJF), while 10% of the consumption occurs during monsoon, when kerosene lighting is the highest. Firewood is the most heavily used fuel source in western India, charcoal in the northern hilly regions, agricultural residues and dung cake in the Indo-Gangetic plains, and kerosene in eastern India. The study shows that ∼20% of residential energy consumption is on account of biomass-based heating and kerosene lighting activities.
A large-scale assessment of the quality of plant genome assemblies using the LTR assembly index
Authors: Mokhtar Morad M , Abd-Elhalim Haytham M , El Allali Achraf 
Published: April 2023

Abstract
Recent advances in genome sequencing have led to an increase in the number of sequenced genomes. However, the presence of repetitive sequences complicates the assembly of plant genomes. The LTR assembly index (LAI) has recently been widely used to assess the quality of genome assembly, as a higher LAI is associated with a higher quality of assembly. Here, we assessed the quality of assembled genomes of 1664 plant and algal genomes using LAI and reported the results as data repository called PlantLAI (https://bioinformatics.um6p.ma/PlantLAI). A number of 55 117 586 pseudomolecules/scaffolds with a total length of 988.11 gigabase-pairs were examined using the LAI workflow. A total of 46 583 551 accurate LTR-RTs were discovered, including 2 263 188 Copia, 2 933 052 Gypsy, and 1 387 311 unknown superfamilies. Consequently, only 1136 plant genomes are suitable for LAI calculation, with values ranging from 0 to 31.59. Based on the quality classification system, 476 diploid genomes were classified as draft, 472 as reference, and 135 as gold genomes. We also provide a free webtool to calculate the LAI of newly assembled genomes and the ability to save the result in the repository. The data repository is designed to fill in the gaps in the reported LAI of existing genomes, while the webtool is designed to help researchers calculate the LAI of their newly sequenced genomes.
Mapping a network for tics in Tourette syndrome using causal lesions and structural alterations
Authors: Zouki Jade-Jocelyne , Ellis Elizabeth G , Morrison-Ham Jordan , Thomson Phoebe , Jesuthasan Aaron , Al-Fatly Bassam , Joutsa Juho , Silk Timothy J , Corp Daniel T 
Published: April 2023

Abstract
Tics are sudden stereotyped movements or vocalizations. Cases of lesion-induced tics are invaluable, allowing for causal links between symptoms and brain structures. While a lesion network for tics has recently been identified, the degree to which this network translates to Tourette syndrome has not been fully elucidated. This is important given that patients with Tourette syndrome make up a large portion of tic cases; therefore, existing and future treatments should apply to these patients. The aim of this study was to first localize a causal network for tics from lesion-induced cases and then refine and validate this network in patients with Tourette syndrome. We independently performed ‘lesion network mapping’ using a large normative functional connectome (n = 1000) to isolate a brain network commonly connected to lesions causing tics (n = 19) identified through a systematic search. The specificity of this network to tics was assessed through comparison to lesions causing other movement disorders. Using structural brain coordinates from prior neuroimaging studies (n = 7), we then derived a neural network for Tourette syndrome. This was done using standard anatomical likelihood estimation meta-analysis and a novel method termed ‘coordinate network mapping’, which uses the same coordinates, yet maps their connectivity using the aforementioned functional connectome. Conjunction analysis was used to refine the network for lesion-induced tics to Tourette syndrome by identifying regions common to both lesion and structural networks. We then tested whether connectivity from this common network is abnormal in a separate resting-state functional connectivity MRI data set from idiopathic Tourette syndrome patients (n = 21) and healthy controls (n = 25). Results showed that lesions causing tics were distributed throughout the brain; however, consistent with a recent study, these were part of a common network with predominant basal ganglia connectivity. Using conjunction analysis, coordinate network mapping findings refined the lesion network to the posterior putamen, caudate nucleus, globus pallidus externus (positive connectivity) and precuneus (negative connectivity). Functional connectivity from this positive network to frontal and cingulate regions was abnormal in patients with idiopathic Tourette syndrome. These findings identify a network derived from lesion-induced and idiopathic data, providing insight into the pathophysiology of tics in Tourette syndrome. Connectivity to our cortical cluster in the precuneus offers an exciting opportunity for non-invasive brain stimulation protocols.
Empress and Virgin: St Cunigunde and Female Sainthood in the Early Thirteenth Century
Authors: Anstatt Antonia 
Published: April 2023

Abstract
This article uses the previously unjustly discarded early thirteenth-century hagiographical text Vitae s. Heinrici additamentum to show how different ideals of female sainthood could be combined within one figure. In two of its chapters, the Additamentum presents two distinct but not contradictory images of its female protagonist, Cunigunde (d. 1033), the wife of the German emperor Henry II (d. 1024). The first chapter of the text portrays Henry and Cunigunde’s marriage as dominated by consensual chastity and emphasizes the spouses’ equality. On their wedding night, within the privacy of their bedchamber, their mutual wish for chastity takes the place of any gendered expressions and is the reason for the blossoming deep affection between them. Following ideals of love and consensual marriage from the twelfth century onwards, this chapter is situated within contemporary discussions of marital affection. In contrast, the third and last chapter of the Additamentum is set within the public space of the imperial court. Cunigunde, a powerful empress, goes through a trial by ordeal to clear herself of an accusation of infidelity. In this chapter, both she and Henry are clearly gendered, but Cunigunde is behaving considerably more ‘manly’ than her husband and ultimately proves herself a saintly virago. Both the ordeal and the virago were predominantly early and central medieval motifs, situating this chapter within a different literary tradition from the first. The Additamentum thus proves the coexistence and possible intertwining of different models of female sainthood.
Symptomatic late saphenous vein graft failure in coronary artery bypass surgery
Authors: Janiec Mikael , Dimberg Axel , Lindblom Rickard P F 
Published: April 2023

Abstract

OBJECTIVES
Coronary artery bypass grafting for advanced coronary artery disease is a well-established procedure with excellent long-term results. The issue of saphenous vein graft (SVG) performance and its relation to clinical symptoms and thereby the potential for improvement by using superior grafts are still not fully understood. We aim to estimate the contribution of late SVG failure to the long-term outcome.

METHODS
A study population operated between 1997 and 2020, with an internal thoracic artery with a single distal anastomosis and 1, 2 or 3 distal SVG anastomoses, was isolated from the Swedish Web System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies registry. Data regarding postoperative clinically driven coronary angiography and status of bypass grafts were collected.

RESULTS
The study population consisted of 44 951 patients. Clinically driven angiography occurred in 10.1% (9.5–10.8), 7.9% (7.6–8.3) and 7.1% (6.7–7.5), respectively, of patients within 3 years and 23.6% (22.6–24.5), 20.0% (19.5–20.6) and 17.5% (16.9–18.2), respectively, of patients within 10 years after surgery. Excluding the first 3 postoperative years, no failed SVGs were found in &gt;75%, 60% and 45%, respectively, of cases when an angiography was performed in the first 10 years after surgery.

CONCLUSIONS
The results suggest that the risk of symptomatic graft failure due to vein graft disease during the first 10 years after surgery is in the range of 1–2% for every grafted coronary vessel and provide an estimate for the upper limit of the improvements in results that could be achieved by replacing SVGs with superior grafts.
The Effect of Design Elements on Simplicity, Usability, and Product Preference: A Video Conference Application Case Study
Authors: Eytam Eleanor 
Published: April 2023

Abstract
Simplicity achieved by minimizing the number of controls is a major guideline for designing usable products. Still, restricting the number of controls in interfaces to achieve simplicity may not be a wise strategy for communicating usability. Our model suggests that although the number of objects in designs helps determine visual simplicity, design elements influence the perceived simplicity of products. Design elements that enhance orientation and structure enable many otherwise-described complex objects to be perceived as simple. To test the effect of simplicity on usability, both visual and perceived simplicity are analyzed. We report a qualitative pilot study and a subsequent experimental study that helped test our model. While the number of objects helped determine the level of simplicity, adding design elements moderated the perceived complexity of control-laden designs. Designs with either a medium or a large number of both objects and design elements were judged as highest for perceived usability.
Inclusion of minor alleles improves catalogue-based prediction of fluoroquinolone resistance inMycobacterium tuberculosis
Authors: Brankin Alice E , Fowler Philip W 
Published: April 2023

AbstractObjectivesFluoroquinolone resistance poses a threat to the successful treatment of tuberculosis. WGS, and the subsequent detection of catalogued resistance-associated mutations, offers an attractive solution to fluoroquinolone susceptibility testing but sensitivities are often less than 90%. We hypothesize that this is partly because the bioinformatic pipelines used usually mask the recognition of minor alleles that have been implicated in fluoroquinolone resistance.MethodsWe analysed the Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC) dataset of globally diverse WGS Mycobacterium tuberculosis isolates, with matched MICs for two fluoroquinolone drugs and allowed putative minor alleles to contribute to resistance prediction.ResultsDetecting minor alleles increased the sensitivity of WGS for moxifloxacin resistance prediction from 85.4% to 94.0%, without significantly reducing specificity. We also found no correlation between the proportion of an M. tuberculosis population containing a resistance-conferring allele and the magnitude of resistance.ConclusionsTogether our results highlight the importance of detecting minor resistance-conferring alleles when using WGS, or indeed any sequencing-based approach, to diagnose fluoroquinolone resistance.
A formal, diagrammatic, and operational study of normative relations
Authors: Pascucci Matteo , Sileno Giovanni 
Published: April 2023

Abstract
In this work, we provide an extensive analysis of Hohfeld’s theory of normative relations, focusing in particular on diagrammatic structures. Our contribution is threefold. First, we specify an extensional formal language to represent the main notions in the two families of normative relations identified by Hohfeld (i.e. the deontic and the potestative family). Our primary focus is on the part of the theory concerning potestative relations. In this regard, we assign a key role to the concept of ability, which is treated as a primitive notion and used to formulate three fine-grained definitions of power (outcome-centered, change-centered and force-centered). Second, on the basis of these definitions we build Aristotelian diagrams of opposition for deontic and potestative relations, improving, extending and systematizing previous proposals formulated in the literature. Third, we present a model-theoretic interpretation and a logic programming (ASP) implementation of the proposed framework, elaborating on the procedural dimension of normative reasoning.