bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-dose Effectiveness of Mpox Vaccine in Quebec, Canada: Test-negative Design With and Without Adjustment for Self-reported Exposure Risk
Authors: Brousseau Nicholas , Carazo Sara , Febriani Yossi , Padet Lauriane , Hegg-Deloye Sandrine , Cadieux Geneviève , Bergeron Geneviève , Fafard Judith , Charest Hugues , Lambert Gilles , Talbot Denis , Longtin Jean , Dumont-Blais Alexandre , Bastien Steve , Dalpé Virginie , Minot Pierre-Henri , De Serres Gaston , Skowronski Danuta M 
Published: September 2023

Abstract

Introduction
During the 2022 mpox outbreak, the province of Quebec, Canada, prioritized first doses for pre-exposure vaccination of people at high mpox risk, delaying second doses due to limited supply. We estimated single-dose mpox vaccine effectiveness (VE) adjusting for virus exposure risk based only on surrogate indicators available within administrative databases (eg, clinical record of sexually transmitted infections) or supplemented by self-reported risk factor information (eg, sexual contacts).

Methods
We conducted a test-negative case-control study between 19 June and 24 September 2022. Information from administrative databases was supplemented by questionnaire collection of self-reported risk factors specific to the 3-week period before testing. Two study populations were assessed: all within the administrative databases (All-Admin) and the subset completing the questionnaire (Sub-Quest). Logistic regression models adjusted for age, calendar-time and exposure-risk, the latter based on administrative indicators only (All-Admin and Sub-Quest) or with questionnaire supplementation (Sub-Quest).

Results
There were 532 All-Admin participants, of which 199 (37%) belonged to Sub-Quest. With exposure-risk adjustment based only on administrative indicators, single-dose VE estimates were similar among All-Admin and Sub-Quest populations at 35% (95% confidence interval [CI]:−2 to 59) and 30% (95% CI:−38 to 64), respectively. With adjustment supplemented by questionnaire information, the Sub-Quest VE estimate increased to 65% (95% CI:1–87), with overlapping confidence intervals.

Conclusions
Using only administrative data, we estimate one vaccine dose reduced the mpox risk by about one-third; whereas, additionally adjusting for self-reported risk factor information revealed greater vaccine benefit, with one dose instead estimated to reduce the mpox risk by about two-thirds. Inadequate exposure-risk adjustment may substantially under-estimate mpox VE.
A machine learning-based score for precise echocardiographic assessment of cardiac remodelling in hypertensive young adults
Authors: Alsharqi Maryam , Lapidaire Winok , Iturria-Medina Yasser , Xiong Zhaohan , Williamson Wilby , Mohamed Afifah , Tan Cheryl M J , Kitt Jamie , Burchert Holger , Fletcher Andrew , Whitworth Polly , Lewandowski Adam J , Leeson Paul 
Published: September 2023

AbstractAimsAccurate staging of hypertension-related cardiac changes, before the development of significant left ventricular hypertrophy, could help guide early prevention advice. We evaluated whether a novel semi-supervised machine learning approach could generate a clinically meaningful summary score of cardiac remodelling in hypertension.Methods and resultsA contrastive trajectories inference approach was applied to data collected from three UK studies of young adults. Low-dimensional variance was identified in 66 echocardiography variables from participants with hypertension (systolic ≥160 mmHg) relative to a normotensive group (systolic &lt; 120 mmHg) using a contrasted principal component analysis. A minimum spanning tree was constructed to derive a normalized score for each individual reflecting extent of cardiac remodelling between zero (health) and one (disease). Model stability and clinical interpretability were evaluated as well as modifiability in response to a 16-week exercise intervention. A total of 411 young adults (29 ± 6 years) were included in the analysis, and, after contrastive dimensionality reduction, 21 variables characterized &gt;80% of data variance. Repeated scores for an individual in cross-validation were stable (root mean squared deviation = 0.1 ± 0.002) with good differentiation of normotensive and hypertensive individuals (area under the receiver operating characteristics 0.98). The derived score followed expected hypertension-related patterns in individual cardiac parameters at baseline and reduced after exercise, proportional to intervention compliance (P = 0.04) and improvement in ventilatory threshold (P = 0.01).ConclusionA quantitative score that summarizes hypertension-related cardiac remodelling in young adults can be generated from a computational model. This score might allow more personalized early prevention advice, but further evaluation of clinical applicability is required.
The Italian Collective Project In Literature, Architecture and the Visual Arts, 1968–77
Authors: Ovan Sabrina 
Published: September 2023

Abstract
During the tumultuous period in Italy between 1968 and 1977, known as the ‘long 68’, myriad alternative publications focusing on the narratives and the experiences of avant-garde groups, marginal communities, labour organizers and political activist circles gained widespread popularity. Among these, two significant literary and political reviews, I Quindici and Contropiano, played a pivotal role in these movements. My paper aims to analyse the aesthetic and textual makeup of these publications by examining the significance of these journals in the context of the explosive political climate that led to the cycle of protests in streets, schools and factories.
Project Respect: experiences of seriously ill LGBTQ+ patients and partners with their health care providers
Authors: Stein Gary L , Berkman Cathy , Acquaviva Kimberly , Woody Imani , Godfrey David , Javier Noelle Marie , O’Mahony Sean , gonzález-rivera christian , Maingi Shail , Candrian Carey , Rosa William E 
Published: September 2023

Abstract
Discrimination against lesbian, gay, bisexual, transgender, and queer (LGBTQ+) persons in health care creates barriers to serious illness care, including patients avoiding or delaying necessary care, providers disrespecting wishes of surrogates, and adverse outcomes for patients and families. A cross-sectional mixed-methods study using an online survey was used to determine the extent to which LGBTQ+ patients and spouses, partners, and widows experienced disrespectful or inadequate care due to sexual orientation or gender identity. A total of 290 LGBTQ+ patients and partners reported high levels of disrespectful and inadequate care, including 35.2% stating their provider was insensitive to them because of their identity; 30% reporting their provider was unaware of LGBTQ+ health needs; 23.1% feeling judged; 20.7% experiencing rudeness; 20.3% stating providers did not use their correct pronouns; and 19.7% reporting their treatment decisions were disregarded. Black and Hispanic patients were 2–4 times more likely than non-Hispanic White patients to report discrimination. This study demonstrated high levels of disrespectful and inadequate care towards patients and partners due to being LGBTQ+, which was especially problematic for Black and Hispanic patients and those living in politically conservative regions. Recommendations include federal and state civil rights laws to prohibit LGBTQ+ discrimination and institutional practices to address discrimination, including cultural sensitivity training for staff.
Plant-based Diets for Inflammatory Bowel Disease: What Is the Evidence?
Authors: Liu Gordon X H , Day Andrew S 
Published: September 2023

Abstract

Background
Inflammatory bowel disease is a chronic incurable condition that carries a high morbidity burden for patients. Plant-based diets have emerged as a potentially safe and effective treatment strategy for this condition. However, no attempt has been made to summarize the literature in this field. In this review, we aim to define variants of plant-based diets that have been studied, evaluate their findings, and identify knowledge gaps that warrant further investigation.

Methods
A literature search was conducted on MEDLINE and Embase.

Results
Twenty-three studies with 2304 participants were included in this review. Eleven studies (48%) were case reports and 8 (35%) were single-arm trials. Semivegetarian diets were the most commonly studied plant-based diet (n = 14, 61%). Most studies reported that plant-based diets were safe and effective in managing inflammatory bowel disease. However, significant limitations restrict the quality and interpretability of these findings, including a paucity of controlled data, small sample sizes, and inconsistent reporting of dietary adherence.

Conclusions
Although initial findings appear promising, it remains unclear whether plant-based diets are an effective adjunct or sole therapy for managing inflammatory bowel disease. Future investigators should aim to conduct methodologically rigorous interventional trials with appropriate control data and consistent and meaningful outcome reporting.
Utility of routine chest radiographs after chest drain removal in paediatric cardiac surgical patients—a retrospective analysis of 1076 patients
Authors: Shetty Gautham , Zouki Jason , Lee Geraldine , Patukale Aditya , Betts Kim S , Justo Robert N , Marathe Supreet P , Venugopal Prem ,   QPCR Group, Suna Jessica , Karl Tom , Alphonso Nelson 
Published: September 2023

Abstract

OBJECTIVES
Chest drains are routinely placed in children following cardiac surgery. The purpose of this study was to determine the incidence of a clinically relevant pneumothorax and/or pleural effusion after drain removal and to ascertain if a chest radiograph can be safely avoided following chest drain removal.

METHODS
This single-centre retrospective cohort study included all patients under 18 years of age who underwent cardiac surgery between January 2015 and December 2019 with the insertion of mediastinal and/or pleural drains. Exclusion criteria were chest drain/s in situ ≥14 days and mortality prior to removal of chest drain/s. A drain removal episode was defined as the removal of ≥1 drains during the same episode of analgesia ± sedation. All chest drains were removed using a standard protocol. Chest radiographs following chest drain removal were reviewed by 2 investigators.

RESULTS
In all, 1076 patients were identified (median age: 292 days, median weight: 7.8 kg). There were 1587 drain removal episodes involving 2365 drains [mediastinal (n = 1347), right pleural (n = 598), left pleural (n = 420)]. Chest radiographs were performed after 1301 drain removal episodes [mediastinal (n = 1062); right pleural (n = 597); left pleural (n = 420)]. Chest radiographs were abnormal after 152 (12%) drain removal episodes [pneumothorax (n = 43), pleural effusion (n = 98), hydropneumothorax (n = 11)]. Symptoms/signs were present in 30 (2.3%) patients. Eleven (&lt;1%) required medical management. One required reintubation and 2 required chest drain reinsertion.

CONCLUSIONS
The incidence of clinically significant pneumothorax/pleural effusion following chest drain removal after paediatric cardiac surgery is low (&lt;1%). Most patients did not require reinsertion of a chest drain. It is reasonable not to perform routine chest radiographs following chest drain removal in most paediatric cardiac surgical patients.
Evolutionary Patterns of Modularity in the Linkage Systems of the Skull in Wrasses and Parrotfishes
Authors: Gartner S M , Larouche O , Evans K M , Westneat M W 
Published: September 2023

Synopsis
The concept of modularity is fundamental to understanding the evolvability of morphological structures and is considered a central framework for the exploration of functionally and developmentally related subsets of anatomical traits. In this study, we explored evolutionary patterns of modularity and integration in the 4-bar linkage biomechanical system of the skull in the fish family Labridae (wrasses and parrotfishes). We measured evolutionary modularity and rates of shape diversification of the skull partitions of three biomechanical 4-bar linkage systems using 205 species of wrasses (family: Labridae) and a three-dimensional geometric morphometrics data set of 200 coordinates. We found support for a two-module hypothesis on the family level that identifies the bones associated with the three linkages as being a module independent from a module formed by the remainder of the skull (neurocranium, nasals, premaxilla, and pharyngeal jaws). We tested the patterns of skull modularity for four tribes in wrasses: hypsigenyines, julidines, cheilines, and scarines. The hypsigenyine and julidine groups showed the same two-module hypothesis for Labridae, whereas cheilines supported a four-module hypothesis with the three linkages as independent modules relative to the remainder of the skull. Scarines showed increased modularization of skull elements, where each bone is its own module. Diversification rates of modules show that linkage modules have evolved at a faster net rate of shape change than the remainder of the skull, with cheilines and scarines exhibiting the highest rate of evolutionary shape change. We developed a metric of linkage planarity and found the oral jaw linkage system to exhibit high planarity, while the rest position of the hyoid linkage system exhibited increased three dimensionality. This study shows a strong link between phenotypic evolution and biomechanical systems, with modularity influencing rates of shape change in the evolution of the wrasse skull.
Early experiences of integrating an artificial intelligence-based diagnostic decision support system into radiology settings: a qualitative study
Authors: Farič Nuša , Hinder Sue , Williams Robin , Ramaesh Rishi , Bernabeu Miguel O , van Beek Edwin , Cresswell Kathrin 
Published: September 2023

Abstract

Objectives
Artificial intelligence (AI)-based clinical decision support systems to aid diagnosis are increasingly being developed and implemented but with limited understanding of how such systems integrate with existing clinical work and organizational practices. We explored the early experiences of stakeholders using an AI-based imaging software tool Veye Lung Nodules (VLN) aiding the detection, classification, and measurement of pulmonary nodules in computed tomography scans of the chest.

Materials and methods
We performed semistructured interviews and observations across early adopter deployment sites with clinicians, strategic decision-makers, suppliers, patients with long-term chest conditions, and academics with expertise in the use of diagnostic AI in radiology settings. We coded the data using the Technology, People, Organizations, and Macroenvironmental factors framework.

Results
We conducted 39 interviews. Clinicians reported VLN to be easy to use with little disruption to the workflow. There were differences in patterns of use between experts and novice users with experts critically evaluating system recommendations and actively compensating for system limitations to achieve more reliable performance. Patients also viewed the tool positively. There were contextual variations in tool performance and use between different hospital sites and different use cases. Implementation challenges included integration with existing information systems, data protection, and perceived issues surrounding wider and sustained adoption, including procurement costs.

Discussion
Tool performance was variable, affected by integration into workflows and divisions of labor and knowledge, as well as technical configuration and infrastructure.

Conclusion
The socio-organizational factors affecting performance of diagnostic AI are under-researched and require attention and further research.
Squamous cell carcinoma of the eyelid
Authors: Sato Yasuyoshi , Takahashi Shunji , Toshiyasu Takashi , Tsuji Hideki , Hanai Nobuhiro , Homma Akihiro 
Published: September 2023

Abstract
Eyelid squamous cell carcinoma is a major type of rare eyelid cancer, together with basal cell carcinoma and sebaceous gland carcinoma. It is a painless disease that progresses slowly and is often detected by the appearance of nodules or plaques. Risk factors include exposure to ultraviolet light, fair skin, radiation and human papillomavirus infection. The standard treatment is surgical removal, and in cases of orbital invasion, orbital content removal is required. If sentinel node biopsy reveals a high risk of lymph node metastasis, adjuvant radiotherapy may be considered. Local chemotherapy, such as imiquimod and 5-fluorouracil, may be used for eyelid squamous cell carcinoma in situ. When surgery or radiotherapy is not recommended for distant metastases or locally advanced disease, drug therapy is often according to head and neck squamous cell carcinoma in Japan. The treatment often requires a multidisciplinary team to ensure the preservation of function and cosmetic appearance.
Cascade testing for hereditary cancer: comprehensive multigene panels identify unexpected actionable findings in relatives
Authors: Heald Brandie , Pirzadeh-Miller Sara , Ellsworth Rachel E , Nielsen Sarah M , Russell Emily M , Beitsch Peter , Esplin Edward D , Nussbaum Robert L , Pineda-Alvarez Daniel E , Kurian Allison W , Hampel Heather 
Published: September 2023

Abstract
Current guidelines recommend single variant testing in relatives of patients with known pathogenic or likely pathogenic germline variants in cancer predisposition genes. This approach may preclude the use of risk-reducing strategies in family members who have pathogenic or likely pathogenic germline variants in other cancer predisposition genes. Cascade testing using multigene panels was performed in 3696 relatives of 7433 probands. Unexpected pathogenic or likely pathogenic germline variants were identified in 230 (6.2%) relatives, including 144 who were negative for the familial pathogenic or likely pathogenic variant but positive for a pathogenic or likely pathogenic variant in a different gene than the proband and 74 who tested positive for the familial pathogenic or likely pathogenic variant and had an additional pathogenic or likely pathogenic variant in a different gene than the proband. Of the relatives with unexpected pathogenic or likely pathogenic germline variants, 36.3% would have qualified for different or additional cancer screening recommendations. Limiting cascade testing to only the familial pathogenic or likely pathogenic variant would have resulted in missed, actionable findings for a subset of relatives.
Chronicles of Disappearance: Palestinian Encampment in the Bekaa Valley (1948–1951)
Authors: Kreichati Cynthia 
Published: September 2023

Abstract
Some formal UN camps in Lebanon are becoming ‘over-researched’ while ‘gatherings’ remain unexplored despite their distinctive features. This article is a historical ethnography of encampment defined as the iterative undertaking of settling in while in exile. It contends that any history of Palestinian encampment must attend to entwined histories of presence, dispersal, and absence. Based on interviews conducted in the gathering of Bar Elias in the Bekaa Valley and on archival research concerned with the quiet disappearance, during the 1950s, of the three camps of Qaraoun, Aanjar and Gouraud, also in the Bekaa, this article explores, through the conceptual frame of presence, the forces shaping Palestinian experience in Lebanon both inside camps and outside of them. Shaped by absence, presence appears as the expression, in each historical situation, of the reality of lived experience and is a lens through which to read the archive of international organizations which rarely encompasses refugee voice.
Multiphase gas nature in the sub-pc region of the active galactic nuclei – II. Possible origins of the changing-state AGNs
Authors: Wada Keiichi , Kudoh Yuki , Nagao Tohru 
Published: September 2023

ABSTRACT
Multiwavelength observations of active galactic nuclei (AGNs) often reveal various time-scales of variability. Among these phenomena, ‘changing-look AGNs’ are extreme cases where broad emission lines become faint/bright or even disappear/emerge between multi-epoch observations, providing crucial information about AGN internal structures. We here focus on ‘changing-state’ AGNs, specifically investigating the transition of optical spectra over years to tens of years. Based on the axisymmetric radiation-hydrodynamic simulations (Paper I) for the gas dynamics within the dust sublimation radius, we investigate the spectral properties of ionized gas exposed to the radiation from an AGN with a 107 M⊙ supermassive black hole. We find significant time-dependent variations in the Balmer emission lines by utilizing post-process pseudo-three-dimensional calculations and the spectral synthesis code cloudy. The equivalent width of H α and H β changes by a factor of 3, or the emission lines even disappear during 30 yr for the same viewing angle. The time-dependent behaviour arises primarily from gas dynamics, particularly the formation of non-steady, radiation-driven outflows within the innermost region of the disc (r ≲ 10−3 pc). The intricate interplay between non-spherical radiation sources at the core of AGNs and the dynamic behaviour of gas within the dust sublimation radius gives rise to radiation-driven outflows. This non-steady outflow potentially contributes to the observed variability in Balmer line emissions over multiyear time-scales in certain AGNs.
The effect of the perturber population on subhalo measurements in strong gravitational lenses
Authors: Coogan Adam , Anau Montel Noemi , Karchev Konstantin , Grootes Meiert W , Nattino Francesco , Weniger Christoph 
Published: September 2023

ABSTRACT
Analyses of extended arcs in strong gravitational lensing images to date have constrained the properties of dark matter by measuring the parameters of one or two individual subhaloes. However, since such analyses are reliant on likelihood-based methods like Markov-chain Monte Carlo or nested sampling, they require various compromises to the realism of lensing models for the sake of computational tractability, such as ignoring the numerous other subhaloes and line-of-sight haloes in the system, assuming a particular form for the source model and requiring the noise to have a known likelihood function. Here, we show that a simulation-based inference method called truncated marginal neural ratio estimation (TMNRE) makes it possible to relax these requirements by training neural networks to directly compute marginal posteriors for subhalo parameters from lensing images. By performing a set of inference tasks on mock data, we verify the accuracy of TMNRE and show it can compute posteriors for subhalo parameters marginalized over populations of hundreds of substructures, as well as lens and source uncertainties. We also find that the multilayer perceptron (MLP) mixer network works far better for such tasks than the convolutional architectures explored in other lensing analyses. Furthermore, we show that since TMNRE learns a posterior function it enables direct statistical checks that would be extremely expensive with likelihood-based methods. Our results show that TMNRE is well-suited for analysing complex lensing data, and that the full subhalo and line-of-sight halo population must be included when measuring the properties of individual dark matter substructures with this technique.