bluuebunny/crossref_metadata_2025_split huggingface dataset:
The MDPIzation of chilean science: a wake-up call about how we are conducting research and using public resources
Authors: Fontúrbel Francisco E. , Celis-Diez Juan L. 
Published: January 2025

AbstractMDPI, a rapidly growing mega-publisher, has significantly impacted scientific publishing with a large number of open-access journals covering all areas of knowledge. Fast publication times, numerous special issues, hundreds of guest editors, and incentives for reviewers contribute to its success. However, concerns have arisen about the quality of its peer-review process and the overall quality of its publications; these practices have led some countries to question the validity of MDPI publications for academic evaluations. MDPI’s influence has surged in Chile, with publications rising from 1 to 13% between 2017 and 2023. While offering a solution to the “publish or perish” pressure, this growth has sparked a debate over the quality and sustainability of such publications. Public funding plays a significant role, with approximately 36% of MDPI papers in Chile financed by public funds through national research programs. This situation has raised concerns about the optimal use of these resources. Chilean science, renowned in South America, faces the challenge of maintaining high standards in the open-access era. The focus should be on quality over quantity to ensure impactful and innovative research contributions.
The application of the facial analysis program Face2Gene in a single genetic counseling center: a retrospective study
Authors: Yahya Dinnar , Stoyanova Milena , Hachmeriyan Mari , Levkova Mariya 
Published: January 2025

Abstract
Background
Face2Gene (F2G) is a software program, widely used in clinical genetics and dysmorphology for recognizing children with genetic disorders. In order to assess its accuracy in real clinical context, we applied F2G to patients from our genetic counseling center.

Results
We randomly selected 151 children, who were referred to genetic counseling because of dysmorphic features and later diagnosed with a particular genetic condition. A frontal photograph was uploaded to the program, and at least three phenotypic traits were selected for each case. Date of birth, sex, weight, height, and head circumference were also entered in the software. The efficacy of the program to correctly diagnose the syndrome based on the facial analysis and/or phenotypic traits was assessed. In 56% (84 cases) of the patients, the F2G program accurately identified the correct diagnosis in its top three suggestions. Forty-seven percent (71 cases) of the patients had the correct diagnosis after applying only facial analysis. There was a statistically significant difference between the two types of analysis—p = 0.001. In 19 of the cases where F2G was unable to identify the correct diagnosis among the top three options based on phenotypic and facial analysis, the diagnosis was included among the 30 suggested syndromes, yielding a total success rate of 68%. The diagnosis was found in the ultra-rare syndromes’ suggestions area in six more cases.

Conclusions
Our results show that F2G has a good overall performance, but adding phenotypic features to the case under study may increase even further its diagnostic capacity.
Myocarditis in malaria—current evidence and future directions: a literature review
Authors: Olatunji Gbolahan , Kokori Emmanuel , Ogieuhi Ikponmwosa Jude , Akinmoju Olumide , Omoworare Oluwatobi , Olatunji Doyin , Isarinade David Timilehin , Odukudu God-dowell O. , Abraham Israel Charles , Owolabi Samuel , Nasrallah Jamil , Egbunu Emmanuel , Jaiyeoba Babafemi Oluwadarasimi , Yusuf Ismaila Ajayi , Olanisa Olawale , Aderinto Nicholas 
Published: January 2025

AbstractMalaria, though witnessing a decline in prevalence, remains a global health threat. Despite its primarily recognized impact on the hematological system, recent studies shed light on severe cardiac complications, particularly myocarditis, associated with Plasmodium infections. This review examines the literature on malaria-induced myocarditis to elucidate its mechanisms, clinical manifestations, regional perspectives, treatment outcomes, and diagnostic challenges. A literature search spanning PubMed, Scopus, and Web of Science identified relevant studies up to January 2024, encompassing case reports, cohort studies, clinical trials, and experimental studies. The relationship between severe malaria and myocardial involvement is explored, showcasing elevated biomarkers indicative of myocardial damage. Notably, while Plasmodium falciparum is traditionally linked to malaria-induced myocarditis, instances of Plasmodium vivax contributing to cardiac complications are documented. Regional perspectives reveal diverse cases, emphasizing the importance of considering malaria-induced myocarditis in endemic regions and beyond. Treatment outcomes underscore the efficacy of timely antimalarial therapy, advocating for integrated approaches to patient care. Diagnostic challenges, often complicated by overlapping symptoms with other cardiac conditions, highlight the need for heightened clinical suspicion. Addressing therapeutic challenges involves balancing antimalarial drugs, supportive care, and long-term monitoring. Future research directions are outlined, emphasizing the necessity for understanding host-parasite interactions, elucidating molecular mechanisms, and developing targeted diagnostic tools. This review consolidates the current knowledge on malaria-induced myocarditis, emphasizing the significance of continuous vigilance, research, and improved diagnostic approaches to mitigate the impact of this overlooked complication.
Parasites: the future of biotherapy
Authors: Singh Ekta , Verma Subhash , Sharma Devina , Parmar Dipali 
Published: January 2025

AbstractBiotherapy targets molecules that alter the immune response. It involves a plethora of organisms known to alter the course of myriad diseases and ailments. Many of these diseases can be life-threatening to the humans and animals, and exhibit resistance to available antimicrobial medications. To address such ailments, traditional and modernized therapies that target specific molecules responsible for altering the immune response are currently being explored. Such therapies utilize various organisms that are known to impact the progression of numerous diseases and disorders. Diseases caused by certain organisms can also alter the courses or outcomes of other diseases. Biotherapies such as helminth therapy, maggot debridement therapy, and hirudotherapy use parasites (roundworms and flatworms), arthropods (maggots), and leeches (annelids), respectively, as potential biological therapeutic sources to treat autoimmune and other chronic diseases. Where conventional medicine fails, these traditional-turned-modern alternative therapies can serve to boost the health prospects of patients who are vulnerable to the misery and pain inflicted by their ailments. Patients dealing with these circumstances are prevalent in developed countries, where there is enormous market potential for any novel alternative treatments discovered. In this review, we provide a brief outlook on the mechanisms of action of these biotherapies, and summarize their roles in human and veterinary medicine.
Aberrant controllability of functional connectome during working memory tasks in patients with schizophrenia and unaffected siblings
Authors: Wang Feiwen , Liu Zhening , Wang Ju , Li Xiao , Pan Yunzhi , Yang Jun , Cheng Peng , Sun Fuping , Tan Wenjian , Huang Danqing , Zhang Jiamei , Liu Xiawei , Zhong Maoxing , Wu Guowei , Yang Jie , Palaniyappan Lena 
Published: January 2025

Background
Working memory deficit, a key feature of schizophrenia, is a heritable trait shared with unaffected siblings. It can be attributed to dysregulation in transitions from one brain state to another.

Aims
Using network control theory, we evaluate if defective brain state transitions underlie working memory deficits in schizophrenia.

Method
We examined average and modal controllability of the brain's functional connectome in 161 patients with schizophrenia, 37 unaffected siblings and 96 healthy controls during a two-back task. We use one-way analysis of variance to detect the regions with group differences, and correlated aberrant controllability to task performance and clinical characteristics. Regions affected in both unaffected siblings and patients were selected for gene and functional annotation analysis.

Results
Both average and modal controllability during the two-back task are reduced in patients compared to healthy controls and siblings, indicating a disruption in both proximal and distal state transitions. Among patients, reduced average controllability was prominent in auditory, visual and sensorimotor networks. Reduced modal controllability was prominent in default mode, frontoparietal and salience networks. Lower modal controllability in the affected networks correlated with worse task performance and higher antipsychotic dose in schizophrenia (uncorrected). Both siblings and patients had reduced average controllability in the paracentral lobule and Rolandic operculum. Subsequent out-of-sample gene analysis revealed that these two regions had preferential expression of genes relevant to bioenergetic pathways (calmodulin binding and insulin secretion).

Conclusions
Aberrant control of brain state transitions during task execution marks working memory deficits in patients and their siblings.
Juntos Permanecemos, Divididos Caímos: Desafios E Perspectivas Para A Liderança Regional Do Uzbequistão Na Ásia Central | Juntos Permanecemos, Divididos Caemos: Desafíos Y Perspectivas Para El Liderazgo Regional De Uzbekistán En Asia Central
Authors: G da Conceição Guilherme 
Published: January 2025

RESUMO
O presente trabalho busca responder de que forma as tentativas de associação malsucedidas na Ásia Central podem indicar o fim do regionalismo centro-asiático frente ao recente papel que o Uzbequistão tem desempenhado enquanto promotor do diálogo e da cooperação local. Para tanto, a pesquisa baseou-se na revisão bibliográfica de fontes primárias e secundárias, e analisa o contexto das iniciativas de integração regional e os motivos que as levaram à extinção. Paralelamente, pretende-se estabelecer um paralelo entre as motivações centro-asiáticas à cooperação e os condicionantes que inviabilizam o seu avanço. Examina-se ainda as potencialidades do governo uzbeque, bem como os alcances e limitações de sua possível liderança na Ásia Central.
Palavras-chave: Regionalismo; Ásia Central; Uzbequistão.

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RESUMEN
El presente estudio tiene como objetivo responder cómo los intentos fallidos de asociación en Asia Central pueden indicar el fin del regionalismo centroasiático a la luz del reciente papel de Uzbekistán como promotor del diálogo y la cooperación local. Para ello, la investigación se basa en una revisión bibliográfica de fuentes primarias y secundarias y analiza el contexto de las iniciativas de integración regional y las razones de su desaparición. Al mismo tiempo, busca establecer un paralelo entre las motivaciones centroasiáticas para la cooperación y los factores que obstaculizan su avance. También se examina el potencial del gobierno uzbeko, así como el alcance y las limitaciones de su posible liderazgo en Asia Central.
Palabras clave: Regionalismo; Asia Central; Uzbekistán.
A Integração Regional Na América Latina E Caribe: Um Estudo Comparado Entre O Mercosul, A Comunidade Andina E A Organização Dos Estados Do Caribe Oriental | Regional Integration In Latin America And The Caribbean: A Comparative Study Between Mercosur, The Andean Community And The Organization Of Eastern Caribbean States
Authors: Tebaldi Bernardo 
Published: January 2025

Das inúmeras iniciativas regionais de integração existentes hoje, o presente estudo teve como foco a análise comparada entre três exemplos existentes na América Latina e Caribe, quais sejam, o Mercosul, a Comunidade Andina e a Organização dos Estados do Caribe Oriental. Partindo do preceito de que, por estarem próximas geograficamente, compartilharem história, cultura e desafios sociais similares, o estudo comparado conseguiria, assim, obter resultados mais próximos e fiéis a realidade de cada uma dessas iniciativas. Assim, o presente estudo organizou-se em duas etapas distintas. A primeira busca apresentar as organizações regionais de integração, focando em seus aspectos institucionais, seus órgãos normativos e decisórios, bem como em suas estruturas jurisdicionais e de fomento. A segunda, as analisa comparativamente, demonstrando as suas semelhanças e diferenças; sendo possível, assim, apontar os rumos escolhidos por cada uma dessas iniciativas de integração regional.
Palavras-chave: Mercosul; Integração Regional; América Latina.

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ABSTRACT
Among the numerous regional integration initiatives existing today, this study focuses on a comparative analysis of three examples in Latin America and the Caribbean: Mercosur, the Andean Community, and the Organization of Eastern Caribbean States. Based on the premise that their geographical proximity, shared history, culture, and similar social challenges allow for more accurate and realistic comparative results, the study is organized into two distinct stages. The first stage introduces the regional integration organizations, focusing on their institutional aspects, normative and decision-making bodies, as well as their jurisdictional and developmental structures. The second stage analyzes them comparatively, highlighting their similarities and differences, thus identifying the paths chosen by each of these regional integration initiatives.
Keywords: Mercosur; Regional Integration; Latin America.
Comércio Internacional Agrícola e Segurança Alimentar: a contribuição de um regime p´ós excepcionalista para a manutenção da resiliência institucional da OMC | Agricultural international trade and food security: the contribution of a post-exceptionalist regime to ensure the institutional resilience of the WTO
Authors: Barbosa Igor Palma 
Published: January 2025

O apoio governamental ao setor agrícola representou uma experiência quase constante dos países desenvolvidos líderes de exportação de alimentos. O atributo de um paradigma excepcionalista para o setor serviu a legitimação destas práticas que resultou na exclusão da liberalização agrícola do texto constitutivo do GATT. Ao final da Rodada do Uruguai, a inauguração de um Acordo sobre Agricultura, ainda pouco restritivo ao protecionismo das grandes potências, sedimentou o estabelecimento de um novo paradigma normativista que prezava pelo protagonismo das forças mercadológicas na esteira das diretrizes neoliberais. Dessa forma, a condução de um estudo de caso para a agenda agrícola no sistema multilateral de comércio permitiu corroborar com a tese de Daugbjerg e Feindt (2017) sobre o potencial de resiliência dos regimes pós excepcionalistas. O presente artigo argumenta que essa configuração contribuiu para garantir longevidade e funcionalidade do texto agrícola da OMC mesmo diante dos impasses da Rodada Doha.
A representação do refúgio na literatura infantojuvenil: uma leitura de Kalil: o menino refugiado
Authors: Carreira Shirley de Souza Gomes 
Published: January 2025

O tema do refúgio pode ser considerado como fraturante, na medida em que aborda questões complexas que, para muitos, são inapropriadas para o público infantojuvenil. Entretanto, a situação do refúgio pode ser apresentada a esses leitores de um modo sensível, que não apenas provoque reflexão, mas também, e principalmente, desenvolva a empatia e a solidariedade para com os refugiados. Nessa perspectiva, propomos a análise do livro Kalil: o menino refugiado, de Fernando Carraro, de modo a demonstrar que a literatura infantojuvenil constitui uma ferramenta importante para o processo de acolhimento e inserção da criança em situação de refúgio no ambiente escolar, ao mesmo tempo em que favorece a interculturalidade.
Effect of short inter-pregnancy interval on perinatal and maternal outcomes among pregnant women in SSA 2023: Systematic review and meta-analysis
Authors: Beyene Fentahun Yenealem , Wudineh Kihinetu Gelaye , Bantie Simachew Animen , Tesfu Azimeraw Arega 
Published: January 2025

Background
After a live birth, the recommended interval before attempting the next pregnancy is at least 24 months (birth to pregnancy interval) in order to reduce the risk of adverse maternal, perinatal and infant outcomes. Short inter pregnancy interval associated with adverse perinatal and maternal outcomes.

Objective
The objective of this review was to determine the effect of short inter pregnancy interval on perinatal and maternal outcomes in Sub-Saharan Africa 2023.

Methods
A systematic and a comprehensive literature searching mechanism were used without any restriction, through Google scholar, PubMed, Scopus, Web of Sciences, and Grey literature databases for reporting the effect of short inter pregnancy interval. The JBI approach to critical appraisal, study selection, data extraction, and data synthesis was used for this review. All statistical analyses were done using STATA version17 software for windows, and meta-analysis was used with a random-effects method. The results are presented using texts, tables and forest plots with measures of effect and 95% confidence interval.

Results
Thirteen studies were included in this review and most of the studies level of heterogeneity across the study was considerable, mainly due to methodological variations, Statistical heterogeneity, and population and intervention variations of included studies. The effect of short inter pregnancy interval on perinatal and maternal outcome were low birth weight(RR (RR (95% CI) 1.98 (1.48, 2.47); I2:62.97%, preterm birth (RR (95% CI) 1.67 (1.31, 2.03); I2:51%, intra uterine growth retardation(RR (95% CI) 3.78 (2.07, 5.49); I2: 8.52%, low APGAR score(RR (95% CI) 3.49 (1.41, 5.57)); I2: 71.11%, premature rapture of membrane(RR (95% CI) 2.87 (1.22, 4.51)); I2: 49.22%, perinatal mortality(RR (95% CI) 2.95 (1.10, 4.81)); I2: 54.37% and maternal anemia(RR (95% CI) 3.06 (2.12, 3.99)); I2: 74.74%.

Conclusions
As per our review the main effect of short inter pregnancy interval is low birth weight, preterm birth, intra uterine growth retardation, low APGAR score, premature rapture of membrane, perinatal mortality and maternal anemia. This might be very useful for healthcare policymakers and NGOs to emphasize on it.
Association between self-reported and proxy informant Health Quality of life of older adults with the use of antipsychotic drugs in nursing homes. A cross-sectional study
Authors: Boucaud-Maitre Denis , Jaballah Fares , Letenneur Luc , Rinaldo Leila , Dartigues Jean-François , Dramé Moustapha , Amieva Hélène , Tabué-Teguo Maturin 
Published: January 2025

Introduction
Antipsychotic prescriptions are frequent in nursing homes due to the challenging management of symptoms associated with Alzheimer’s disease and related neurodegenerative disorders. This study aimed to assess the association between Health-related Quality Of Life (HrQOL) and antipsychotic use in nursing homes.

Methods
This is a cross-sectional study of the KASEHPAD (Karukera Study of Ageing in Nursing Homes) study conducted in six nursing homes in Guadeloupe and Martinique (French West Indies). The EuroQol 5-dimensional questionnaire (EQ-5D) was used to measure HRQoL. Clinical characteristics and use of antipsychotic drugs of 194 older adults with both self-reported and proxy informant HrQOL index were extracted. Other outcomes measures included the frequency and severity of delusions, hallucinations and agitation using the reduced Neuropsychiatric Inventory Nursing Home (NPI-R) score, Activities of Daily Living (ADL) score and Mini-Mental State Examination (MMSE) score.

Results
The mean age of participants was 81.3 years and 63.6% had major cognitive impairment (MMSE score ≤18). The prevalence of delusions (39.7%), hallucinations (27.8%) and agitation (40.7%) was high. Antipsychotic medication was prescribed to 37.1% of the participants. The self-reported HrQOL Index of older adults was higher than the proxy HrQOL Index (0.54 ± 0.43 versus 0.40 ± 0.43) with a correlation coefficient of 0.63 (p<0.001). The use of antipsychotic medication was associated with a higher self-reported HrQOL index, after controlling for the frequency (β = 0.144, p = 0.024) or severity (β = 0.159, p = 0.009) of delusions, hallucinations and agitation symptoms. Conversely, antipsychotic use was not associated with proxy HrQOL Index.

Conclusion
Despite the adverse effects of long-term use of antipsychotic drugs in older adults, it is associated with better-perceived HrQOL among nursing home residents. However, this association was not observed when HrQOL was assessed by proxy informants. This finding may explain the challenges in reducing the use of this therapeutic class in nursing homes.
Incidence rate of total knee arthroplasties in eleven European countries: Do they reach a plateau?
Authors: Le Stum Mathieu , Le Goff-Pronost Myriam , Stindel Eric , Dardenne Guillaume 
Published: January 2025

Background
From several decades, the evolutions of the Incidence Rate (IR) of Primary Knee Arthroplasties are continuously increasing worldwide and have been widely studied in several countries. Some recent works have highlighted the fact that the IR is following a sigmoid curve composed of an exponential growth followed by a linear phase and finished by a plateau. Our objective is to assess the IR evolution of eleven European countries, representing thus a large proportion of this continent, regarding this sigmoid.

Methods
IRs of primary knee arthroplasties for Austria, Denmark, Finland, France, Germany, Hungary, Italy, Poland, Spain, Sweden, and the United Kingdom between 2005 and 2019 were retrieved from the EUROSTAT database. Several regression models were fitted to each country’s IRs: Poisson, linear, asymptotic, logistic, and Gompertz regression. For each country and each model, the RMSE (Root Mean Square Error) and R2 were calculated and used to estimate their position with respect to this sigmoid curve.

Results
The best regression models for knee arthroplasties varied following countries. Logistic and Gompertz regressions had the lowest RMSE and R2 values for Austria, Denmark, Germany, Sweden, and the UK. Hungary, Italy, and Poland favored the Poisson regression model. Finland and Spain presented difficulties in determining the optimal model (linear or Poisson), while France faced challenges in choosing between logistic, Gompertz, and linear regression.

Conclusion
In conclusion, the growth dynamics of IR differ across European countries. Some countries seem to have already reached a plateau and will therefore experience slight growth in the future.