bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of the amygdala‐medial orbitofrontal relationship in odor recognition in the elderly
Authors: Sakikawa Kei , Masaoka Yuri , Honma Motoyasu , Yoshikawa Akira , Yoshida Masaki , Kamimura Sawa , Ida Masahiro , Kobayashi Hitome , Izumizaki Masahiko 
Published: March 2023

AbstractIntroductionIn patients with mild cognitive impairment, pathological changes begin in the amygdala (AMG) and hippocampus (HI), especially in the parahippocampal gyrus and entorhinal cortex (ENT). These areas play an important role in olfactory detection and recognition. It is important to understand how subtle signs of olfactory disability relate to the functions of the above‐mentioned regions, as well as the orbitofrontal cortex (OFC). In this study, we evaluated brain activation using functional magnetic resonance imaging (fMRI), performed during the presentation of olfactory stimuli (classified as “normal odors” not inducing memory retrieval), and investigated the relationships of the blood oxygen level‐dependent (BOLD) signal with olfactory detection and recognition abilities in healthy elderly subjects.MethodsTwenty‐four healthy elderly subjects underwent fMRI during olfaction, and raw mean BOLD signals were extracted from regions of interest, including bilateral regions (AMG, HI, parahippocampus, and ENT) and orbitofrontal subregions (frontal inferior OFC, frontal medial OFC, frontal middle OFC, and frontal superior OFC). Multiple regression and path analyses were conducted to understand the roles of these areas in olfactory detection and recognition.ResultsActivation of the left AMG had the greatest impact on olfactory detection and recognition, while the ENT, parahippocampus, and HI acted as a support system for AMG activation. Less activation of the right frontal medial OFC was associated with good olfactory recognition. These findings improve our understanding of the roles of limbic and prefrontal regions in olfactory awareness and identification in elderly individuals.ConclusionFunctional decline of the ENT and parahippocampus crucially impacts olfactory recognition. However, AMG function may compensate for deficits through connections with frontal regions.
Not just apologizing: The impact of complaint handling on sustained participation behavior in live‐streaming shopping
Authors: Zhang Wenkun , Wang Yanan 
Published: March 2023

AbstractIn a live‐streaming shopping community, the quality of complaint handling may significantly influence relationship recovery between the consumer and retailer (or streamer) following service failures. Despite the significant progress made in previous works, there are still research gaps in the study of customer complaint handling and customers' post‐behavior. Therefore, this study introduced the important variable “swift‐guanxi” (SG) to explore the relationship between complaint handling and the sustained participation of customers. Data were collected through both online and offline methods. A structural equation model (SEM) was used to test the relevant hypotheses. The results from assessing these data indicate that the factors of conversational human voice (CHV), reply length (RL) and perceived justice (PJ) all exert a significant influence on SG, which in turn affects the sustained participation behavior (SPB) of customers. In addition, complaint publicization (CP) has a negative impact on this behavior.
Rationalizing the Optimization of Detergents for Membrane Protein Purification
Authors: Urner Leonhard H. , Junge Florian , Fiorentino Francesco , El‐Baba Tarick J. , Shutin Denis , Nölte Gideon , Haag Rainer , Robinson Carol V. 
Published: March 2023

AbstractMembrane protein purification by means of detergents is key to isolating membrane‐bound therapeutic targets. The role of the detergent structure in this process, however, is not well understood. Detergents are optimized empirically, leading to failed preparations, and thereby raising costs. Here we evaluate the utility of the hydrophilic‐lipophilic balance (HLB) concept, which was introduced by Griffin in 1949, for guiding the optimization of the hydrophobic tail in first‐generation, dendritic oligoglycerol detergents ([G1] OGDs). Our findings deliver qualitative HLB guidelines for rationalizing the optimization of detergents. Moreover, [G1] OGDs exhibit strongly delipidating properties, regardless of the structure of the hydrophobic tail, which delivers a methodological enabling step for investigating binding strengths of endogenous lipids and their role for membrane protein oligomerization. Our findings will facilitate the analysis of challenging drug targets in the future.
Structural Requirements of a Glycolipid MPIase for Membrane Protein Integration
Authors: Fujikawa Kohki , Han Youjung , Osawa Tsukiho , Mori Shoko , Nomura Kaoru , Muramoto Maki , Nishiyama Ken‐ichi , Shimamoto Keiko 
Published: March 2023

AbstractMPIase is a glycolipid involved in membrane protein integration in the inner membrane of Escherichia coli. To overcome the trace amounts and heterogeneity of natural MPIase, we systematically synthesized MPIase analogs. Structure‐activity relationship studies revealed the contribution of distinctive functional groups and the effect of the MPIase glycan length on membrane protein integration activity. In addition, both the synergistic effects of these analogs with the membrane chaperone/insertase YidC, and the chaperone‐like activity of the phosphorylated glycan were observed. These results verified the translocon‐independent membrane integration mechanism in the inner membrane of E. coli, in which MPIase captures the highly hydrophobic nascent proteins via its characteristic functional groups, prevents protein aggregation, attracts the proteins to the membrane surface, and delivers them to YidC in order to regenerate its own integration activity.
Liquid‐Liquid Extraction of Caproic and Caprylic Acid: Solvent Properties and pH
Authors: Yuan Bomin , Braune Maria , Gröngröft Arne 
Published: March 2023

AbstractCaproic acid (C6) and caprylic acid (C8) can be produced during anaerobic fermentation via chain elongation processes. This study focused on the selective recovery of C6 and C8 from a fermentation broth with liquid‐liquid extraction. Eight solvents, including alcohols, esters, an organophosphorus compound, and an amine, were evaluated based on their extraction efficiency and selectivity for C6 and C8. The highest extraction efficiency of C6 (46 %) and C8 (93 %) at pH 6.0 was achieved by 1‐octanol. Oleyl alcohol, 1‐decanol, and 1‐octanol had the highest selectivity for C6 and C8.
Association between lipoprotein(a) and peripheral arterial disease in coronary artery bypass grafting patients
Authors: Yi Cheng , Junyi Gao , Fengju Liu , Qing Zhao , Jie Chen 
Published: March 2023

AbstractObjectivePeripheral arterial disease (PAD) affects a large population and is associated with various adverse clinical outcomes. Lipoprotein(a) has proatherogenic properties and is associated with PAD incidence and severity. The aim of this study is to explore the association between LP(a) and PAD in coronary artery bypass grafting (CABG) patients.MethodsA total of 1001 patients were included and divided into two groups: low Lp(a) group [LP(a) < 30 mg/dL] and high Lp(a) group [LP(a) ≥ 30 mg/dL]. A comparison of PAD incidence diagnosed by ultrasound was made between the groups. Multivariate logistic regression was conducted to explore the risk factors for PAD. During the analysis, the influence of diabetes mellitus (DM) and gender on LP(a) serum level was taken into consideration.ResultsDM history (odds ratio [OR], 2.330, p = .000 for males; OR, 2.499, p = .002 for females) and age (OR, 1.101, p = .000 for males; OR, 1.071, p = .001 for females) were risk factors for PAD. LP(a) ≥ 30 mg/dL was a risk factor for PAD only in female patients (OR, 2.589, p = .003), while smoking history was a risk factor only in male patients (OR, 1.928, p = .000). LP(a) level was not associated with PAD severity in DM patients of both gender. As for female patients without DM, PAD was more severe in the high LP(a) group.ConclusionsIn CABG patients, DM history and age were risk factors for PAD. But a high level of LP(a) was a significant risk factor only in female patients. In addition, we are the first to propose a gender deviation in the correlation between LP(a) serum level and severity of PAD diagnosed by ultrasound.
Double Hook Perylene Diimide as a New Receptor for PAHs: An Experimental and Theoretical Study
Authors: Rodríguez‐Uribe Nadia Alejandra , Contreras‐Martínez Rodrigo , Jaime‐Adán Everardo , García‐Betancourt María Luisa , Bernal‐Uruchurtu Margarita I. , Godoy‐Alcántar Carolina 
Published: March 2023

AbstractIn a one‐step reaction, we prepared a dibenzylamine perylene diimide derivative (PDI). Its double hook structure allows for self‐association with a constant of Kd ∼108 M−1 determined by fluorescence. We confirmed its ability to bind PAHs using UV/Vis, fluorescence, and 1H NMR titrations in CHCl3. The complex formation signature in UV/vis is a new band at 567 nm. The calculated binding constants (Ka∼104 M−1) follow the trend pyrene>perylene>phenanthrene>naphthalene>anthracene. Theoretical modeling of these systems using DFT ωB97X‐D/6‐311G(d,p) proved helpful in rationalizing the complex formation and the observed association trend. The distinctive signal in UV/vis is due to a charge transfer in the complex from orbitals in the guest to the host. SAPT(DFT) confirmed that the driving forces in the complex formation are exchange and dispersion (π–π interactions). Still, the recognition ability depends on the electrostatic component of the interaction, a minor fraction.
Effects of Various Valence Ions on an Aqueous Rechargeable Zn//Polyaniline‐coated ZnMn2O4 Battery
Authors: Liu Yu , Liu Yu Xia , Lv Rongguan , Han Mei , Chang Yingna , Zhao Zhiyuan , Sun Yuzhen , Hoang Tuan K. A. , Xing Rong 
Published: March 2023

AbstractZinc corrosion and dendrite formation are the main issues which impede the performance of aqueous zinc ion batteries (ZIBs) after certain times. In this work, we systematically investigated the effects of three different valence ions (e. g., Na+, Mg2+, Al3+) as electrolyte additives on the suppression of zinc corrosion and the inhibition of dendrite growth. By combining experiments and theoretical calculations, it has been found that the existence of Na+ ions effectively suppressing the zinc dendrite growth because Na+ possessess high adsorption energy approximately −0.39 eV. Moreover, Na+ ions could lengthen the zinc dendrite formation duration up to 500 h. On the other hand, the PANI/ZMO cathode materials showed the small band gap approximately 0.097 eV, signifying that the PANI/ZMO possessed the semiconductor characteristics. Furthermore, an assembled Zn//PANI/ZMO/GNP full battery using Na+ ions as electrolyte additive displayed capacity retention of 90.2 % after 500 cycles at 0.2 A g−1, whereas the capacity retention of the control battery using pure ZnSO4 electrolyte was only 58.2 %. This work could provide a reference for the selection of electrolyte additives in future batteries.
Design, synthesis, and biological evaluation of pleuromutilin derivatives containing 1,2,4‐triazole linker
Authors: Zhou Zi‐Dan , Hu Yu‐Han , Wang Qi , Xu Heng , Xi Gao‐Lei , Liu Yan , Gu Liang , Jin Zhen , Tang You‐Zhi 
Published: March 2023

AbstractA series of thioether pleuromutilin derivatives containing 1,2,4‐triazole on the side chain of C14 were designed and synthesized. The in vitro antibacterial activities experiments of the synthesized derivatives showed that compounds 72 and 73 displayed superior in vitro antibacterial effect against MRSA minimal inhibitory concentration (MIC = 0.0625 μg/mL) than tiamulin (MIC = 0.5 μg/mL). The results of time‐kill study and postantibiotic effect study indicated that compound 72 could inhibit the growth of MRSA quickly (−2.16 log10 CFU/mL) and showed certain postantibiotic effect (PAE) time (exposure to 2 × MIC and 4 × MIC for 2 h, the PAE was 1.30 and 1.35 h) against MRSA. Furthermore, the binding mode between compound 72 and 50S ribosome of MRSA was explored by molecular docking and five hydrogen bonds were formed between compound 72 and 50S ribosome.
Observation of a rapid lake‐drainage event in the Arctic: Set‐up and trigger mechanisms, outburst flood behaviour, and broader fluvial impacts
Authors: Arp Christopher D. , Drew Katie A. , Bondurant Allen C. 
Published: March 2023

AbstractLakes set in arctic permafrost landscapes can be susceptible to rapid drainage and downstream flood generation. Of many thousands of lakes in northern Alaska, hundreds have been identified as having high drainage potential directly to river systems and 18 such drainage events have been documented since 1955. In 2018 we began monitoring a large lake with high drainage potential as part of a long‐term hydrological observation network designed to evaluate impacts of land use and climate change. In early June 2022, surface water was observed flowing over a 30‐m wide bluff, with active headward erosion of ice‐rich permafrost soils apparent by late June. This overflow point breached rapidly in early July, draining almost the entire lake within 12 h and generating a 191 m3/s flood to a downstream creek. Water level and turbidity sensors and time‐lapse cameras captured this rapid lake‐drainage event at high resolution. A wind‐driven surface seiche and warming waters following ice‐out helped trigger the initial thermomechanical breach. We estimate at least 600 MT of lake sediment was eroded, mobilized, and transported downstream. A flood wave peaking at 42 m3/s arrived 14 h after the initial breach at a river gauge 9‐km downstream. Comparing this event with three other quantified arctic lake‐drainage floods suggests that lake surface area coupled with drainage gradient height can predict outburst flood magnitude. Using this relationship we estimated future flood hazards from the 146 lakes in the Arctic Coastal Plain of northern Alaska (ACP) with high drainage potential, of which 20% are expected to generate outburst floods exceeding 100 m3/s to downstream rivers. This fortunate and detailed drainage‐event observation adds to a growing body of research on the impact of lakes on arctic hydrology, hazard forecasting in a region with an increasing human footprint, and broader processes of landscape evolution in arctic lowlands.
A prospective observational evaluation of an online health care professional training program to promote healthy pregnancy weight gain
Authors: Nicoll Evelyn , Wilkinson Shelley A. , Braithwaite Simone , de Jersey Susan 
Published: March 2023

AbstractIssue AddressedA lack of programs to develop clinician knowledge and confidence to address weight gain within pregnancy is a barrier to the provision of evidence‐based care.AimTo examine the reach and effectiveness of the Healthy Pregnancy Healthy Baby online health professional training program.MethodsA prospective observational evaluation applied the reach and effectiveness elements of the RE‐AIM framework. Health professionals from a range of disciplines and locations were invited to complete questionnaires before and after program completion assessing objective knowledge and perceived confidence around aspects of supporting healthy pregnancy weight gain, and process measures.ResultsThere were 7577 views across all pages over a year period, accessed by participants across 22 Queensland locations. Pre‐ and post‐ training questionnaires were completed 217 and 135 times, respectively. The proportion of participants with scores over 85% and of 100% for objective knowledge was higher post training (P ≤ .001). Perceived confidence improved across all areas for 88%–96% of those who completed the post‐ training questionnaire. All respondents would recommend the training to others.ConclusionsClinicians from a range of disciplines, experience and locations accessed and valued the training, and knowledge of, and confidence in delivering care to support healthy pregnancy weight gain improved after completion.So What?This effective program to build the capacity of clinicians to support healthy pregnancy weight gain offers a model for online, flexible training highly valued by clinicians. Its adoption and promotion could standardise the support provided to women to encourage healthy weight gain during pregnancy.
A multifunctional optical‐thermal logic gate sensor array based on ferroelectric BiFeO3 thin films
Authors: Wu Li , Ji Yun , Dan Huiyu , Bowen Chris R. , Yang Ya 
Published: March 2023

AbstractThe growing need to process a diverse range of data has ignited effort in developing new multifunctional logic gate devices. In this article, we report a new form of all‐in‐one logic gate system that exploits the photoresponsivity of a self‐powered multifunctional BiFeO3 (BFO) sensor material. The BFO sensor can not only detect both light intensity and temperature, but it can also execute three common logic gates of “AND”, “OR”, and “NOT” by converting optical and thermal inputs into electrical output. The diverse functionality of the BFO logic gate sensor array utilizes the unique light‐and temperature‐controlled energy band structure and carrier behavior of the BFO material. To demonstrate the potential, a 3 × 3 logic gate sensor matrix is developed, which successfully detected light and temperature distributions, and accurately produced the three basic logic gate operations. This work provides a new route to construct highly integrated multifunctional electronic devices for the advancement of large sensing, communication, and computing operations.image
Al-Gazali Skeletal Dysplasia Constitutes the Lethal End of ADAMTSL2-Related Disorders
Authors: Batkovskyte Dominyka , McKenzie Fiona , Taylan Fulya , Simsek-Kiper Pelin Ozlem , Nikkel Sarah M , Ohashi Hirofumi , Stevenson Roger E , Ha Thuong , Cavalcanti Denise P , Miyahara Hiroyuki , Skinner Steven A , Aguirre Miguel A , Akçören Zühal , Utine Gulen Eda , Chiu Tillie , Shimizu Kenji , Hammarsjö Anna , Boduroglu Koray , Moore Hannah W , Louie Raymond J , Arts Peer , Merrihew Allie N , Babic Milena , Jackson Matilda R , Papadogiannakis Nikos , Lindstrand Anna , Nordgren Ann , Barnett Christopher P , Scott Hamish S , Chagin Andrei S , Nishimura Gen , Grigelioniene Giedre 
Published: March 2023

ABSTRACT
Lethal short-limb skeletal dysplasia Al-Gazali type (OMIM %601356), also called dysplastic cortical hyperostosis, Al-Gazali type, is an ultra-rare disorder previously reported in only three unrelated individuals. The genetic etiology for Al-Gazali skeletal dysplasia has up until now been unknown. Through international collaborative efforts involving seven clinical centers worldwide, a cohort of nine patients with clinical and radiographic features consistent with short-limb skeletal dysplasia Al-Gazali type was collected. The affected individuals presented with moderate intrauterine growth restriction, relative macrocephaly, hypertrichosis, large anterior fontanelle, short neck, short and stiff limbs with small hands and feet, severe brachydactyly, and generalized bone sclerosis with mild platyspondyly. Biallelic disease-causing variants in ADAMTSL2 were detected using massively parallel sequencing (MPS) and Sanger sequencing techniques. Six individuals were compound heterozygous and one individual was homozygous for pathogenic variants in ADAMTSL2. In one of the families, pathogenic variants were detected in parental samples only. Overall, this study sheds light on the genetic cause of Al-Gazali skeletal dysplasia and identifies it as a semi-lethal part of the spectrum of ADAMTSL2-related disorders. Furthermore, we highlight the importance of meticulous analysis of the pseudogene region of ADAMTSL2 where disease-causing variants might be located. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
The feasibility of early response evaluation using superb microvascular imaging one day after transcatheter arterial chemoembolization for hepatocellular carcinoma
Authors: Oh Soeui , Kwon Heejin , Lim Kyungjae , Cho Jinhan , Kang Eunju , Kim Sanghyun , Baek Yanghyun 
Published: March 2023

AbstractPurposeThe purpose of this study was to determine the feasibility of early Superb microvascular imaging (SMI) for prediction of the effect of HCC treatment after transcatheter arterial chemoembolization (TACE).Materials and MethodsA total of 96 HCCs (70 patients) treated with TACE between September 2021 and May 2022 were included in this study. SMI, Color Doppler imaging (CDI), and Power Doppler imaging (PDI) were performed the day after TACE for evaluation of intratumoral vascularity of the lesion using an Aplio500 ultrasound scanner (Toshiba Medical Systems, Corporation, Tochigi, Japan). Grading of the vascular presence was performed using a five‐point scale. A dynamic CT image taken after 29–42 days was used for comparison of sensitivity, specificity, and accuracy for detection of tumor vascularity between SMI, CDI, and PDI. Univariate and multivariate analysis were performed for assessment of factors affecting intratumoral vascularity.ResultsFifty‐eight lesions (60%) showed complete remission (CR) and 38 lesions (40%) showed partial response (PR) or no response at 29–42 days on Multi‐detector Computed Tomography (MDCT) after TACE. SMI showed sensitivity of 86.84% for detection of intratumoral flow, which was significantly higher compared with that of CDI (10.53%, p < 0.001) and PDI (36.84%, p < 0.001). The results of multivariate analysis indicated that tumor size was a significant factor in detection of blood flow using the SMI technique.ConclusionEarly SMI may be utilized as an adjunctive diagnostic test for evaluation of treated lesions after TACE, particularly when the location of the tumor is in an area of the liver where a suitable sonic window can be identified.
Identification of immunogenic cell death‐associated subtypes and characterization of the tumor microenvironment in endometrial cancer
Authors: Pan Fang , Luo Yonghua , Wang Lanyu , Cheng Yulan , Bu Wenxia , Zhao Xinyuan , Xu Yiwen , Chen Lin , Wang Hongxing 
Published: March 2023

AbstractImmunogenic cell death (ICD) is one of the mechanisms regulating cell death, which activates adaptive immunity in immunocompetent hosts and is associated with tumor progression, prognosis and therapeutic response. Endometrial cancer (EC) is one of the most common malignancies of the female genital tract, and the potential role of immunogenic cell death‐related genes (IRGs) in the tumor microenvironment (TME) remains unclear. We describe the variation of IRGs and assess the expression patterns in EC samples from The Cancer Genome Atlas and Gene Expression Omnibus cohorts. Based on the expression of 34 IRGs, we identified two different ICD‐related clusters and subsequently differentially expressed genes between the two ICD‐related clusters were used for the identification of two ICD gene clusters. We identified the clusters and found that alterations in the multilayer IRG were associated with patient prognosis and TME cell infiltration characteristics. On this basis, ICD score risk scores were calculated, and ICD signatures were constructed and validated for their predictive power in EC patients. To help clinicians better apply the ICD signature, an accurate nomogram was constructed. The low ICD risk group was characterized by high microsatellite instability, high tumor mutational load, high IPS score and stronger immune activation. Our comprehensive analysis of IRGs in EC patients suggested a potential role in the tumor immune interstitial microenvironment, clinicopathological features and prognosis. These findings may improve our understanding of the role of ICDs, and provide a new basis for assessing prognosis and developing more effective immunotherapeutic strategies in EC.