bluuebunny/crossref_metadata_2025_split huggingface dataset:
OEDL: an optimized ensemble deep learning method for the prediction of acute ischemic stroke prognoses using union features
Authors: Ye Wei , Chen Xicheng , Li Pengpeng , Tao Yongjun , Wang Zhenyan , Gao Chengcheng , Cheng Jian , Li Fang , Yi Dali , Wei Zeliang , Yi Dong , Wu Yazhou 
Published: June 2023

BackgroundEarly stroke prognosis assessments are critical for decision-making regarding therapeutic intervention. We introduced the concepts of data combination, method integration, and algorithm parallelization, aiming to build an integrated deep learning model based on a combination of clinical and radiomics features and analyze its application value in prognosis prediction.MethodsThe research steps in this study include data source and feature extraction, data processing and feature fusion, model building and optimization, model training, and so on. Using data from 441 stroke patients, clinical and radiomics features were extracted, and feature selection was performed. Clinical, radiomics, and combined features were included to construct predictive models. We applied the concept of deep integration to the joint analysis of multiple deep learning methods, used a metaheuristic algorithm to improve the parameter search efficiency, and finally, developed an acute ischemic stroke (AIS) prognosis prediction method, namely, the optimized ensemble of deep learning (OEDL) method.ResultsAmong the clinical features, 17 features passed the correlation check. Among the radiomics features, 19 features were selected. In the comparison of the prediction performance of each method, the OEDL method based on the concept of ensemble optimization had the best classification performance. In the comparison to the predictive performance of each feature, the inclusion of the combined features resulted in better classification performance than that of the clinical and radiomics features. In the comparison to the prediction performance of each balanced method, SMOTEENN, which is based on a hybrid sampling method, achieved the best classification performance than that of the unbalanced, oversampled, and undersampled methods. The OEDL method with combined features and mixed sampling achieved the best classification performance, with 97.89, 95.74, 94.75, 94.03, and 94.35% for Macro-AUC, ACC, Macro-R, Macro-P, and Macro-F1, respectively, and achieved advanced performance in comparison with that of methods in previous studies.ConclusionThe OEDL approach proposed herein could effectively achieve improved stroke prognosis prediction performance, the effect of using combined data modeling was significantly better than that of single clinical or radiomics feature models, and the proposed method had a better intervention guidance value. Our approach is beneficial for optimizing the early clinical intervention process and providing the necessary clinical decision support for personalized treatment.
Association of markers of inflammation on attention and neurobehavioral outcomes in survivors of childhood acute lymphoblastic leukemia
Authors: Cheung Yin Ting , To Kenneth Kin-Wah , Hua Rong , Lee Chui Ping , Chan Agnes Sui-Ying , Li Chi Kong 
Published: June 2023

BackgroundSurvivors of childhood acute lymphoblastic leukemia (ALL) are at-risk of developing cognitive impairment and neurobehavioral symptoms. Inflammation induced by a compromised health status during cancer survivorship is proposed as a pathophysiological mechanism underlying cognitive impairment in cancer survivors.ObjectivesTo evaluate the associations of biomarkers of inflammation with attention and neurobehavioral outcomes in survivors of childhood ALL, and to identify clinical factors associated with biomarkers of inflammation in this cohort.MethodsWe recruited patients who were diagnosed with ALL at ≤ 18 years old and were currently ≥5 years post-cancer diagnosis. The study outcomes were attention (Conners Continuous Performance Test) and self-reported behavioral symptoms (Adult Self-Report [ASR] checklist). Using a commercial screening kit, survivors’ plasma (5ml) was assayed for 17 cytokines/chemokine cell-signaling molecules that are associated with neurodegenerative diseases. The final panel of the targeted markers included interleukin (IL)-8, IL-13, interferon-gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1β, and tumor necrosis factor-α. Biomarker levels were rank-ordered into tertiles based on the sample distribution. Multivariable general linear modeling was used to test for associations between biomarkers and study outcomes in the overall cohort and stratified by gender.ResultsThis study included 102 survivors (55.9% males, mean[SD] age 26.2[5.9] years; 19.3[7.1] years post-diagnosis). Survivors within top tertiles of IFN-γ (Estimate =6.74, SE=2.26; P=0.0037) and IL-13 (Estimate =5.10, SE=2.27; P=0.027) demonstrated more inattentiveness. Adjusting for age, gender and treatment, more self-reported thought (Estimate=3.53, SE=1.78; P=0.050) and internalizing problems (Estimate =6.52, SE=2.91; P=0.027) correlated with higher IL-8. Higher levels of IL-13 (RR = 4.58, 95% CI: 1.01–11.10) and TNF-α (RR = 1.44, 95% CI: 1.03–4.07) were observed in survivors had developed chronic health conditions (n=26, 25.5%). The stratified analysis showed that association of IFN-γ with attention was stronger in male survivors than in female survivors.ConclusionInflammation due to cancer-related late effects may potentially be mechanistic mediators of neurobehavioral problems in pediatric ALL survivors. Markers of inflammation can potentially be applied to assess or monitor the effectiveness of interventions, particularly behavioral interventions, in improving cognitive outcomes in survivors. Future work includes understanding the underlying gender-specific pathophysiology behind functional outcomes in the population.
“Get on with it. Cope.” The compassion-experience during COVID-19 in UK universities
Authors: Denney Fiona 
Published: June 2023

IntroductionThe COVID-19 pandemic caused major disruption to all sectors including higher education during the years of 2020 and 2021, thus providing a window into how different types of suffering can combine and the role of compassion in alleviating pain. Higher education within the United Kingdom provides a case example in this study, but the lessons about compassion are transferable to other contexts, particularly those in the neoliberal public sector. The impact of the pandemic period on teaching in universities has been well documented but there has been far less written about the wider experiences of staff who worked through this period, their suffering and the extent of compassion within their work lives.Methods29 interviews were conducted and individuals were invited to talk through the story of their pandemic experiences from March 2020 to the interview date of December 2021. Storytelling is a common method in organization studies and, although research into compassion in organizations is nascent, this method has been used in other studies.Results and discussionPrevious research has examined organizational compassion in short periods of crisis and this study therefore provides a contrasting perspective on how compassion shifts over a longer period of suffering. A distinction is drawn in this study for the first time between “formalized” compassion processes in the organization which structurally prioritized compassion for students over that of staff, and “informal” compassion shown between staff to each other and between students and staff. The more that formalized compassion was evident, the less apparent it was in interpersonal interactions due to staff wellbeing being compromised and a systemic failure to recognize the dependence of student compassion on the wellbeing of staff. The findings therefore lead to theorizing that although neoliberal universities are perceived as being full of organizational neglect, compassion was structurally embedded for students but at the expense of staff.
Parental burnout of parents of primary school students: an analysis from the perspective of job demands-resources
Authors: Zhao Jiangtao , Hu Hua , Zhao Siqin , Li Wenwen , Lipowska Małgorzata 
Published: June 2023

ObjectiveBased on the theory of Job Demands-Resources, this study has been set out to examine how parenting demands, parenting resources affect parental burnout of primary school students’ parents.MethodsAn online survey with four scales (Parenting Stress Scale, Perceived Family Support Scale, Psychological Resilience Scale and Parental Burnout Scale) was completed by 600 parents of students from three primary schools in Central China. Structural equation models were implemented.ResultsParenting stress had a positive impact on parental burnout (β = 0.486, p &lt; 0.001). Both perceived family support (β = −0.228, p &lt; 0.001) and psychological resilience (β = −0.332, p = 0.001) had a negative impact on parental burnout. Perceived family support played a moderating role between parenting stress and parental burnout (β = −0.121, p &lt; 0.001). Psychological resilience also played a moderating role between parenting stress and parental burnout (β = −0.201, p &lt; 0.001). Psychological resilience partially mediated the relationship between perceived family support and parental burnout. The total effect was −0.290, with 95% CI (−0.350, −0.234). Direct effect was −0.228, with 95% CI (−0.283, −0.174), and indirect effect was −0.062, with 95% CI (−0.092, −0.037).ConclusionParental burnout may be reduced by increasing family support and self-improvement of psychological resilience. In the same way, the impact of parenting stress on parental burnout may be buffered under high-pressure situations.
Association between family functioning and psychotic transition in ultra-high risk adolescents and young adults
Authors: Adrien Vladimir , Liewig Justine , Diot Thomas , Ferreri Florian , Mouchabac Stephane , Dubertret Caroline , Bourgin Julie 
Published: June 2023

BackgroundPsychotic transition (PT) is a crucial stage in schizophrenia. The Comprehensive Assessment of At-Risk Mental States (CAARMS) scale can be used to identify individuals at ultra-high risk (UHR) for psychosis and to evaluate their risk of PT. Many environmental and genetic factors have been identified as contributing to the development and decompensation of schizophrenia. This study aimed to determine if the quality of family functioning is associated with PT risk in UHR individuals aged between 11 and 25 years after 1 year of follow-up.MethodsFrom January to November 2017, 45 patients aged 12 to 25 consulting for psychiatric reasons were included. Twenty-six were classified as UHR of PT at the CAARMS. Family functioning was assessed by the Family Assessment Device—Global Functioning (FAD-GF). Thirty-seven of these patients (30% men, mean age 16 ± 2.5) were reassessed at 8–14 months of recruitment. Survival analysis was used to examine the impact of family functioning on PT risk.ResultsA total of 40% of UHR patients were classified as psychotic at reassessment. Survival analysis showed that better family functioning is a significant protective factor for PT in this population.DiscussionThis result suggests that the global family functioning has an impact at 1 year on the risk of PT in the population of adolescents and young adults who consult the hospital for psychiatric reasons. A family intervention may be effective in reducing PT risk in this population and should be considered as a potential therapeutic option.
Evaluation of Monkeypox- and Vaccinia virus-neutralizing antibodies in human serum samples after vaccination and natural infection
Authors: Manenti Alessandro , Solfanelli Niccolò , Cantaloni Paolo , Mazzini Livia , Leonardi Margherita , Benincasa Linda , Piccini Giulia , Marchi Serena , Boncioli Martina , Spertilli Raffaelli Chiara , Tacconi Danilo , Mattiuzzo Giada , Kistner Otfried , Montomoli Emanuele , Trombetta Claudia Maria 
Published: June 2023

IntroductionIn early to mid-2022, an unexpected outbreak of Monkeypox virus infections occurred outside the African endemic regions. Vaccines originally developed in the past to protect against smallpox are one of the available countermeasures to prevent and protect against Orthopoxvirus infections. To date, there are few studies on the cross-reactivity of neutralizing antibodies elicited by previous vaccinia virus-based vaccination and/or Monkeypox virus infection. The aim of this study was to evaluate a possible approach to performing Monkeypox and vaccinia live-virus microneutralization assays in which the read-out is based on the production of cytopathic effect in the cell monolayer.MethodsGiven the complexity of Orthopoxviruses, the microneutralization assay was performed in such a way as to uncover a potential role of complement, with and without the addition of an external source of Baby Rabbit Complement. A set of human serum samples from individuals who had been naturally infected with Monkeypox virus and individuals who may have and not have undergone vaccinia virus vaccinations, was used to evaluate the performance, sensitivity, and specificity of the assay.Results and conclusionsThe results of the present study confirm the presence and cross-reactivity of antibodies elicited by vaccinia-based vaccines, which proved able to neutralize the Monkeypox virus in the presence of an external source of complement.
CIRS-LAS – a novel approach to increase transparency in laboratory animal science for improving animal welfare by reducing laboratory animal distress
Authors: Enkelmann Astrid , Bischoff Sabine J. 
Published: June 2023

The 3Rs principle is highly topical in animal-based research. These include, above all, new scientific methods for conducting experiments without an animal model, by using non-animal models (Replace), reducing the number of laboratory animals (Reduction) or taking measures to keep the stress on the laboratory animal as low as possible (Refinement). Despite numerous modern alternative approaches, the complete replacement of animal experiments is not yet possible.The exchange in the team about the daily work with laboratory animals, about open questions and problems, contributes to a reflection of one’s own work and to a better understanding of the work of the others. CIRS-LAS (Critical Incident Reporting System in Laboratory Animal Science) represents a reporting system for incidents in laboratory animal science. It is urgently needed because the lack of transparency about incidents leads to the repetition of failed experiments. Negative experiences from animal-based experiments are often not mentioned in publications, and the fear of hostility is still very high. Therefore, a constructive approach to errors is not a matter of course. To overcome this barrier, CIRS-LAS was created as a web-based database. It addresses the areas of reduction and refinement of the 3Rs principle by providing a platform to collect and analyze incidents. CIRS-LAS is open to all individuals working with laboratory animals worldwide and currently exists with 303 registered members, 52 reports, and an average of 71 visitors per month.The development of CIRS-LAS shows, that an open and constructive error culture is difficult to establish. Nevertheless, the upload of a case report or the search in the database leads to an active reflection of critical occurrences. Thus, it is an important step towards more transparency in laboratory animal science. As expected, the collected events in the database concern different categories and animal species and are primarily reported by persons involved in an experiment. However, reliable conclusions about observed effects require further analysis and continuous collection of case reports. Looking at the development of CIRS-LAS, its high potential is shown in considering the 3Rs principle in daily scientific work.
Estimation of genetic parameters of pig reproductive traits
Authors: Yang Yiting , Gan Mailin , Yang Xidi , Zhu Peng , Luo Yi , Liu Bin , Zhu Kangping , Cheng Wenqiang , Chen Lei , Zhao Ye , Niu Lili , Wang Yan , Zhang Hui , Wang Jingyong , Shen Linyuan , Zhu Li 
Published: June 2023

IntroductionIn this study, we aimed to estimate the genetic parameters of the reproductive traits in three popular commercial pig breeds: Duroc, Landrace, and Yorkshire. Additionally, we evaluated the factors that influence these traits.MethodWe collected data from a large number of litters, including 1,887 Duroc, 21,787 Landrace, and 74,796 Yorkshire litters. Using the ASReml-R software to analyze 11 traits, which included: total number of pigs born (TNB); number of piglets born alive (NBA); number of piglets born healthy (NBH); number of piglets born weak (NBW); number of new stillborn piglets (NS); number of old stillborn piglets (OS); number of piglets born with malformation (NBM); number of mummified piglets (NM); total litter birthweight (LBW); litter average weight (LAW); duration of gestational period (GP). We investigated the effects of 4 fixed factors on the genetic parameters of these traits.ResultsAmong the 11 reproductive-related traits, the gestational period belonged to the medium heritability traits (0.251–0.430), while remaining traits showed low heritability, ranging from 0.005 to 0.159. TNB, NBA, NBH, LBW had positive genetic correlation (0.737 ~ 0.981) and phenotype correlation (0.711 ~ 0.951). There was a negative genetic correlation between NBW and LAW (−0.452 ~ −0.978) and phenotypic correlation (−0.380 ~ −0.873). LBW was considered one of the most reasonable reproductive traits that could be used for breeding improvement. Repeatability of the three varieties was within the range of 0.000–0.097. In addition, the fixed effect selected in this study had a significant effect on Landrace and Yorkshire (p &lt; 0.05).DiscussionWe found a positive correlation between LBW and TNB, NBA, and NBH, suggesting the potential for multi-trait association breeding. Factors such as farm, farrowing year, breeding season, and parity should be taken into consideration in practical production, as they may impact the reproductive performance of breeding pigs.
Combined Experimental and Numerical Investigation of a Hypersonic Turbulent Boundary Layer by Means of FLDI and Large-Eddy Simulations
Authors: Camillo Giannino Ponchio , Wagner Alexander , Toki Takahiko , Scalo Carlo 
Published: June 2023

This work investigates a hypersonic turbulent boundary layer over a 7° half angle cone at a wall-to-total temperature ratio of 0.1, M∞=7.4 and Re∞m=4.2×106 m−1, in terms of density fluctuations and the convection velocity of density disturbances. Experimental shock tunnel data are collected using a multi-foci Focused Laser Differential Interferometer (FLDI) to probe the boundary layer at several heights. In addition, a high-fidelity, time-resolved Large-Eddy Simulation (LES) of the conical flowfield under the experimentally observed free stream conditions is conducted. The experimentally measured convection velocity of density disturbances is found to follow literature data of pressure disturbances. The spectral distributions evidence the presence of regions with well-defined power laws that are present in pressure spectra. A framework to combine numerical and experimental observations without requiring complex FLDI post-processing strategies is explored using a computational FLDI (cFLDI) on the numerical solution for direct comparisons. Frequency bounds of 160 kHz <f<1 MHz are evaluated in consideration of the constraining conditions of both experimental and numerical data. Within these limits, the direct comparisons yield good agreement. Furthermore, it is verified that in the present case, the cFLDI algorithm may be replaced with a simple line integral on the numerical solution.
Pré Peyret 1 (Gresse-en-Vercors, Isère, 1 620 m). Une station mésolithique de montagne
Authors: Picavet Régis , Angelin Alexandre 
Published: June 2023

Located on the “ Hauts plateaux”, a large area selected as a natural reserve in the center of the “ Parc naturel régional du Vercors”, the “ Pré Peyret 1 and 2” mesolithic settlements have been discovered in 1998 by Regis Picavet and Sébastien Bernard-Guelle, during an archeological survey sponsored by the natural Park. During the year 1999, several survey tests were realized, revealing us an important mesolithic occupation. During the years 2007-2008, two archeological excavation campaigns have been organized at the “ Pré Peyret 1” settlement, located on a tiny hill, directed by Régis Picavet. Twenty square meters have been excavated and the numerous lithic artifacts have been assigned to the first and second Mesolithic cultures. These conditions allow
a palethnographic approach, which yet remains incomplete. The “ Pré Peyret 1” settlements belong to a large series of human occupations in altitude already known on the “ Hauts Plateaux” area and more generally in the alpine world, participating at a seasonal system of mountain attendance. Interrelations may be founded with the “ Grande Rivoire” (580 m asl.), mesolithic settlements giving us lots of cultural and archeobiological informations which are missing in open air sites.
Physical activity and sports science in Italian scientific research products
Authors: D'Elia Francesca , D'Isanto Tiziana , Esposito Giovanni , Altavilla Gaetano , Raiola Gaetano 
Published: June 2023

Purpose. This study aims to measure the number of scientific production of Italian researchers, as framed on academic disciplines of Physical training and methodology (code M-EDF/01) and Sports science and methodology (code M-EDF/02), afferents to the academic recruitment field of Exercise and sports science (code 06/N2) and Didactics, special education and educational research (code 11/D2).
Material and Methods. The sample consisted of the entire population of full professors (n=30) belonging to the two academic disciplines of Physical training and methodology and Sports science and methodology, plus a proportional representation of the two academic recruitment fields with at least one associate professor per university, for a total of 124 researchers. The titles of the first ten scientific products in terms of more citations from the Google Scholar database were analysed for each researcher. The full consistency of the title with the scientific statement of the two academic disciplines was assessed, identifying the number of articles afferent to sports and physical activity, biomedical and Psycho-pedagogical domains. One-way ANOVA was used to compare the two academic disciplines of the two academic recruitment fields with the three domains.
Results. The aggregate data showed a prevalence of the biomedical domain over the sport and physical activity ones in both the academic disciplines, in the academic recruitment field of Exercise and sports science. On the other hand, in the academic recruitment of Didactics, special education and educational research, there was a prevalence of the sport and physical activity domain over the biomedical ones. In addition, modest Psycho-pedagogical and biomedical scientific production were found in the academic recruitment fields of Exercise and sports science and Didactics, special education and educational research, respectively.
Conclusions. The problem of the different coherence of the scientific profiles of the researchers concerning the relevant academic recruitment field and possibly also to the two academic disciplines was confirmed.