bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment of a reference interval for 12‐hour fasted serum gastrin concentration in adult dogs
Authors: Vose Julieann , Brudvig Jean , Bassiouny Enass , Petroff Brian , Jaffey Jared , Cridge Harry 
Published: August 2023

AbstractBackgroundAdherence to traditional 24‐h fasting periods for serum gastrin concentration in dogs can be challenging and may delay the institution of therapies for suspected hypergastrinemia. Peer‐reviewed publications regarding serum gastrin reference intervals (RI) are lacking. Hypercalcemia is associated with hypergastrinemia in people; limited data exist in dogs.ObjectiveThe objective of the study was to generate a RI for a 12‐h fasted serum gastrin concentration in dogs and to investigate whether correlations exist with age, weight, sex, and total calcium concentration.MethodsFifty‐five healthy adult dogs (>1 year of age). The screening included: medical history, physical examination, CBC (15 dogs), and serum chemistry (55 dogs). Gastrin was measured via a commercial radioimmunoassay. The RI for 12‐h fasted serum gastrin concentration was calculated according to the recommendations of the American Society for Veterinary Clinical Pathology. Additionally, data were evaluated for correlation with selected variables.ResultsThe RI for serum gastrin following a 12‐h fasting period was 15.1–78.9 ng/L with 90% confidence intervals for the lower and upper limits of 14.0–22.9 and 68.3–83.0 ng/L, respectively. A generalized linear model did not detect significant relationships between gastrin and age (P = 0.48), sex (P = 0.30), weight (P = 0.93), or total calcium concentration (P = 0.84).ConclusionsA 12‐h fasted serum gastrin concentration RI has been established. Given the limited range of serum calcium concentrations in our healthy study population, additional investigations are needed to determine the effects of hypercalcemia on serum gastrin concentrations in dogs and for any potential clinical consequences thereof.
The geographic distributions and complex genetic relationships among four Sorghum taxa identified in Taiwan
Authors: Hsieh Wei‐Hsun , Liao Hsien‐Chun , Chin Han‐Shiuan , Kuo Yi‐Tzu , Chen Chih‐Hui , Tsai Yuan‐Ching , Paterson Andrew H. , Lin Yann‐Rong 
Published: August 2023

AbstractThe genus Sorghum consists of 25 species, including Sorghum bicolor (L.) Moench, one of the top five cereal crops cultivated globally, and S. halepense, one of the most noxious weeds. Weedy Sorghum possesses outstanding adaptability and drought tolerance thrives in diverse environments and becomes an invasive plant worldwide. Taiwan is a unique place possessing suitable habitats for four Sorghum taxa, S. bicolor ssp. bicolor, var. technicum, ssp. verticilliflorum and S. halepense, which were identified by key morphological features. The four Sorghum taxa showed distinct geographic distributions, revealing that invasiveness was influenced by their own characteristics and human activities. The sporadic distributions of cultivated S. bicolor ssp. bicolor and var. technicum may be attributed to human disturbance and agricultural activities. The rhizomatous S. halepense was widely distributed and showed the highest genetic diversity (He > 0.776) among the four taxa, with its strong adaptation to various environments threatening the agricultural practices and ecosystem in Taiwan. In contrast, the newly naturalised S. bicolor ssp. verticilliflorum was confined to and dominant in southern Taiwan, with the lowest genetic diversity (He < 0.272). Significant genetic differentiation (FST = 0.5207) between the two ssp. verticilliflorum subpopulations was associated with natural geographic isolation. This study concretely elucidated the geographic distributions, genetic diversity and relatedness of invasive and escaped Sorghum taxa, indicating the potential aggressiveness and hazard of weedy Sorghum in Taiwan.
Cross-Domain Transfer Learning for Galvanized Steel Strips Defect Detection and Recognition
Authors: Chen Hao , Lin Hongbin , Xu Qingfeng , Li Yaguan , Zheng Yiming , Fei Jianghua , Yang Kang , Fan Wenhui , Nie Zhenguo 
Published: August 2023

Abstract
Defect detection is a crucial direction of deep learning, which is suitable for industrial inspection of product quality in strip steel. As the strip steel production line continuously outputs products, it is necessary to take corresponding measures for the type of defect, once a subtle quality problem is found on steel strips. We propose a new defect area detection and classification method for automation strip steel defect detection. In order to eliminate the way of insufficient data in industrial production line scenarios, we design a transfer learning scheme to support the training of defect region detection. Subsequently, in order to achieve a more accurate classification of defect categories, we designed a deep learning model that integrated the detection results of defect regions and defects feature extraction. After applying our method to the test set and production line, we can achieve extremely high accuracy, reaching 87.11%, while meeting the production speed of the production line compared with other methods. The accuracy and speed of the model realize automatic quality monitoring in the manufacturing process of strip steel.
The 2-Point Method: Theoretical Basis, Methodological Considerations, Experimental Support, and Its Application Under Field Conditions
Authors: García-Ramos Amador 
Published: August 2023

The “2-point method,” originally referred to as the “2-load method,” was proposed in 2016 by Prof Slobodan Jaric to characterize the maximal mechanical capacities of the muscles to produce force, velocity, and power. Two years later, in 2018, Prof Jaric and I summarized in a review article the scientific evidence showing that the 2-point method, compared with the multiple-point method, is capable of providing the outcomes of the force–velocity (F–V) and load–velocity (L–V) relationships with similar reliability and high concurrent validity. However, a major gap of our review was that, until 2018, the feasibility of the 2-point method had only been explored through testing procedures based on multiple (more than 2) loads. This is problematic because (1) it has misled users into thinking that implementing the 2-point method inevitably requires testing more than 2 conditions and (2) obtaining the data from the same test could have artificially inflated the concurrent validity of the 2-point method. To overcome these limitations, subsequent studies have implemented in separate sessions the 2-point method under field conditions (only 2 different loads applied in the testing protocol) and the standard multiple-point method. These studies consistently demonstrate that while the outcomes of the 2-point method exhibit comparable reliability, they tend to have slightly higher magnitudes compared with the standard multiple-point method. This review article emphasizes the practical aspects that should be considered when applying the 2-point method under field conditions to obtain the main outcomes of the F–V and L–V relationships.
Supplemental Material: Rheological heterogeneities at the roots of the seismogenic zone
Authors: Volpe Giuseppe , al. et 
Published: August 2023

<p>SM1 (Coulomb stress change); SM2 (basement geometries); SM3 (clustering methods); SM4 (cross-correlation analysis); SM5 (clusters); SM6 (experimental apparatus and procedures); SM7 (basement gouges); and SM8 (seismicity cutoff evolution). </p>
Management of acute non-specific low back pain in the emergency department: do emergency physicians follow the guidelines? Results of a cross-sectional survey
Authors: Jermini-Gianinazzi Ilaria , Blum Manuel , Trachsel Maria , Trippolini Maurizio Alen , Tochtermann Nicole , Rimensberger Caroline , Liechti Fabian Dominik , Wertli Maria M 
Published: August 2023

ObjectivesClinical guidelines for acute non-specific low back pain (LBP) recommend avoiding imaging studies or invasive treatments and to advise patients to stay active. The aim of this study was to evaluate the management of acute non-specific LBP in the emergency departments (ED).SettingWe invited all department chiefs of Swiss EDs and their physician staff to participate in a web-based survey using two clinical case vignettes of patients with acute non-specific LBP presenting to an ED. In both cases, no neurological deficits or red flags were present. Guideline adherence and low-value care was defined based on current guideline recommendations.ResultsIn total, 263 ED physicians completed at least one vignette, while 212 completed both vignettes (43% residents, 32% senior/attending physicians and 24% chief physicians). MRI was considered in 31% in vignette 1 and 65% in vignette 2. For pain management, non-steroidal anti-inflammatory drugs, paracetamol and metamizole were mostly used. A substantial proportion of ED physicians considered treatments with questionable benefit and/or increased risk for adverse events such as oral steroids (vignette 1, 12% and vignette 2, 19%), muscle relaxants (33% and 38%), long-acting strong opioids (25% and 33%) and spinal injections (22% and 43%). Although guidelines recommend staying active, 72% and 67% of ED physicians recommended activity restrictions.ConclusionManagement of acute non-specific LBP in the ED was not in agreement with current guideline recommendations in a substantial proportion of ED physicians. Overuse of imaging studies, the use of long-acting opioids and muscle relaxants, as well as recommendations for activity and work restrictions were prevalent and may potentially be harmful.
COVID-19 pandemic stress and cancer symptom burden
Authors: Ballesteros Olivia , Mark Sueann , Block Astrid , Mackin Lynda , Paul Steven , Cooper Bruce , Abbott Maura , Chang Susan , Hammer Marilyn J , Levine Jon , Pozzar Rachel , Snowberg Karin , Tsai Katy , Van Blarigan Erin , Van Loon Katherine , Miaskowski Christine A 
Published: August 2023

ObjectivesIn a sample of patients with cancer (n=1145) who were assessed during the height of the COVID-19 pandemic, latent profile analysis was used to identify subgroups of patients with distinct stress profiles and to evaluate for differences in demographic and clinical characteristics and symptom severity scores among these subgroups.MethodsPatients completed measures of cancer-specific and COVID-19 stress, global stress, social isolation, loneliness, depression, state and trait anxiety, morning and evening fatigue, morning and evening energy, sleep disturbance, cognitive function, and pain. Latent profile analysis was used to identify subgroups of patients with distinct stress profiles. Differences among the subgroups in study measures were evaluated using parametric and non-parametric tests.ResultsUsing clinically meaningful cut-off scores for the stress measures, four distinct stress profiles were identified (ie, none class (51.3%); low stress and moderate loneliness class (24.4%), high stress and moderate loneliness class (14.0%), and very high stress and moderately high loneliness class (high, 10.3%)). Risk factors associated with membership in the high class included: younger age, lower annual household income, lower functional status and higher comorbidity burden. The two worst stress profiles reported clinically meaningful levels of all of the common symptoms associated with cancer and its treatments.ConclusionFindings from this study, obtained prior to the availability of COVID-19 vaccines and anti-viral medications, provide important ‘benchmark data’ to evaluate for changes in stress and symptom burden in patients with cancer in the postvaccine era and in patients with long COVID-19.
Tumor-Targeted Nonablative Radiation Promotes Solid Tumor CAR T-cell Therapy Efficacy
Authors: Quach Hue Tu , Skovgard Matthew S. , Villena-Vargas Jonathan , Bellis Rebecca Y. , Chintala Navin K. , Amador-Molina Alfredo , Bai Yang , Banerjee Srijita , Saini Jasmeen , Xiong Yuquan , Vista William-Ray , Byun Alexander J. , De Biasi Andreas , Zeltsman Masha , Mayor Marissa , Morello Aurore , Mittal Vivek , Gomez Daniel R. , Rimner Andreas , Jones David R. , Adusumilli Prasad S. 
Published: August 2023

Abstract
Infiltration of tumor by T cells is a prerequisite for successful immunotherapy of solid tumors. In this study, we investigate the influence of tumor-targeted radiation on chimeric antigen receptor (CAR) T-cell therapy tumor infiltration, accumulation, and efficacy in clinically relevant models of pleural mesothelioma and non–small cell lung cancers. We use a nonablative dose of tumor-targeted radiation prior to systemic administration of mesothelin-targeted CAR T cells to assess infiltration, proliferation, antitumor efficacy, and functional persistence of CAR T cells at primary and distant sites of tumor. A tumor-targeted, nonablative dose of radiation promotes early and high infiltration, proliferation, and functional persistence of CAR T cells. Tumor-targeted radiation promotes tumor-chemokine expression and chemokine-receptor expression in infiltrating T cells and results in a subpopulation of higher-intensity CAR-expressing T cells with high coexpression of chemokine receptors that further infiltrate distant sites of disease, enhancing CAR T-cell antitumor efficacy. Enhanced CAR T-cell efficacy is evident in models of both high-mesothelin-expressing mesothelioma and mixed-mesothelin-expressing lung cancer—two thoracic cancers for which radiotherapy is part of the standard of care. Our results strongly suggest that the use of tumor-targeted radiation prior to systemic administration of CAR T cells may substantially improve CAR T-cell therapy efficacy for solid tumors. Building on our observations, we describe a translational strategy of “sandwich” cell therapy for solid tumors that combines sequential metastatic site–targeted radiation and CAR T cells—a regional solution to overcome barriers to systemic delivery of CAR T cells.
Parental rejection and control: Potential risks for excessive Internet usage among adolescents
Authors: Tom Annmary , Thomas Bino , Sharma Manoj , Joseph Anoop 
Published: August 2023

Background: Internet addiction is an emergent health hazard among adolescents, especially after COVID19. Parenting factors in a family environment specifically, have potential roles in either causing excessive internet usage, or in protecting teenagers from internet addiction. Aim: The aim of the study was to understand factors in parent-adolescent relationship that determine low and excessive internet usage. Methods: A total of 102 adolescents within the age group of 13 to 18 years from two different schools in urban Bengaluru, India were recruited. Data was collected using three instruments namely semi structured tool to assess socio-demographic characteristics, Young’s internet addiction test for internet usage and parental bonding instrument for adolescent perception about parenting dimensions. Results: Half of the participants were found to have mild to severe levels of internet addiction, and the remaining half had normal levels of internet usage. The results showed that decreased care and increased control from the mother, high autonomy from father and increased rejection from both parents as risk factors associated with adolescent internet excessive use. No other significant associations were found between adolescents’ demographic, academic, peer and school profile and their internet addiction. Conclusion: As internet has become an inevitable part of our life, parent-adolescent relationship forms an essential moderating factor in adolescents’ internet usage.
Association of clozapine treatment and rate of methamphetamine or amphetamine relapses and abstinence among individuals with concurrent schizophrenia spectrum and amphetamine use disorder: A retrospective cohort study
Authors: Rafizadeh Reza , Frankow Laura , Mahmood Hajer , Poonia Sukhpreet , Mathew Nickie , Danilewitz Marlon , Bousman Chad A , Honer William G , Schütz Christian G 
Published: August 2023

Background: Preliminary evidence suggest clozapine is associated with more favorable impact on concurrent substance use disorder related outcomes in patients with concurrent schizophrenia spectrum disorders (SSD). At the same time, there is a dearth of evidence with regards to clozapine outcomes in the context of concurrent methamphetamine or amphetamine use disorder (MAUD). Aims: To examine whether clozapine use decreases rate of methamphetamine or amphetamine (MA) relapses and increases the likelihood of maintaining abstinence from any MA use. Methods: A descriptive-analytic retrospective cohort study was conducted on individuals with SSD-MAUD in an inpatient provincial treatment and rehabilitation center for concurrent disorders. Antipsychotic exposure was categorized as “on clozapine” or “on other antipsychotic(s).” Data were collected using electronic health records. Logistic regression was used to examine association of clozapine treatment with likelihood of complete abstinence from MA use for the duration of antipsychotic exposure. Negative binomial regression was used to examine association of clozapine treatment with rate of MA relapses for the duration of antipsychotic exposure. Results: The majority of the 87 included patients were male. Ethnicity was diverse, with the largest groups self-identifying as Indigenous and European. Clozapine use was both associated with increased likelihood of maintaining abstinence from MA use (adjusted odds ratio (aOR) = 3.05, 95% confidence intervals (CI) = 1.15–8.1, p = 0.025), and decreased rate of MA relapses (aRR = 0.45, 95% CI = 0.25–0.82, p = 0.009) for the duration of antipsychotic exposure. Co-prescription of psychostimulants was associated with increased rate of MA relapses (aRR = 2.43, 95% CI = 1.16–5.10, p = 0.019). Conclusion(s): In this study, clozapine use compared with other antipsychotics in SSD was associated with improved outcomes related to severe concurrent MAUD. Co-prescription of psychostimulant medications was associated with a poor outcome.
Sinus Arrest Related to Dexmedetomidine Infusion in an Infant; a Case Report and Review of Current Literature
Authors: Dennee Alexandra , Fogarty Thomas P. , Howard Taylor S. , Hunter Ryan Brandon 
Published: August 2023

Background: Dexmedetomidine, an alpha 2 agonist, has emerged as a desirable sedative agent in the pediatric intensive care unit due to its minimal effect on respiratory status and reduction in delirium. Bradycardia and hypotension are common side effects, however there are emerging reports of more serious cardiovascular events, including sinus arrest and asystole. These case reports have been attributed to high vagal tone or underlying cardiac conduction dysfunction. Objectives: To describe the development of sinus arrest during sedation with dexmedetomidine in a patient without clinical features of high vagal tone, underlying cardiac conduction dysfunction, or intervening episodes of bradycardia. Case Presentation: An 11 month-old patient requiring sedation during mechanical ventilation for acute respiratory failure secondary to Adenovirus. To facilitate sedation, a dexmedetomidine infusion was initiated at .5 mcg/kg/hr and increased to maximum 1 mcg/kg/hr. Within 8 hours of initiating therapy, the patient had three episodes of sinus arrest. There was no intervening bradycardia between episodes and no further episodes occurred following discontinuation of dexmedetomidine. The patient did not have any clinical features associated with high vagal tone or underlying cardiac conduction dysfunction. Conclusions: As result of these findings, understanding risk factors for bradycardia, or more serious hemodynamic instability with dexmedetomidine infusions, is important to help identify high risk patients and weigh the associated risks and benefits of its administration.
Higher education institutions and stakeholder analysis: Theoretical roots, development of themes and future research directions
Authors: Syed Raihan Taqui , Singh Dharmendra , Agrawal Reena , Spicer David 
Published: August 2023

Theoretical roots of higher education institutions (HEIs) and Stakeholder Analysis date back to mid-1990s and research was focussed on the role of HEIs in society and sustainable development. While various studies have been published about ‘triple-helix model’ - bringing government, academia, and industry closer, the concept of HEIs and Stakeholder Analysis needs a comprehensive review of the work carried out till date. Bibliometric and content analyses were performed, incorporating citations from Scopus’ database during last 25 years. Thematic mapping was carried out and evolving trends were identified. Findings and analysis of this research disclosed that during the last 25 years there has been a growing interest among scholars towards Stakeholder Analysis and HEIs. It was also noted that majority of research pursuits concentrated in western countries such as USA and UK, while Africa, Asia and South America were under-represented. This work will not only lay a foundation for academics to carry out further research, but it will also give new insights to the policymakers which would enable them to device strategies aiming at enhanced participation of universities/HEIs in the local, regional, and national development.
Parental Mental Health and Challenges in Parenting of Pre-schoolers During the COVID-19 Pandemic
Authors: Ganie Aasim Ur Rehman , Krishna Jayanthi P.M.  , Nambiar Priyanka P. , Jangam Kavita V. 
Published: August 2023

Background: This study aimed to understand the parental stress, psychological distress, and parenting practices of parents of pre-schoolers during the COVID-19 pandemic. Methods and Materials: An online cross-sectional survey was conducted with the parents of preschool children aged 3–6 years. Researchers used the Parental Stress Scale, Self-Reporting Questionnaire, and Parent Practice Interview to collect data from parents in the Southern Indian city of Bengaluru. Results: A total of 60 responses were obtained from the online survey. Moderate to a high level of parental stress and mild to moderate levels of psychological distress were found among the parents. Around 21 (35%) of parents were found in need of mental health consultation. The study found no group differences in parental stress and psychological distress among various socio-demographic variables. The study found a significant association between parental stress and the parenting practices of participants. Higher mean scores were observed on mothers in setting clear expectations of pre-schoolers. Conclusion: Parenting young pre-schoolers is a difficult task. COVID-19 pandemic has made the parenting process challenging for parents. Parents must engage the children at home, and helping them cope with the new environment is a tightrope walk. Such uncertainties are supposed cause distress and lead to poor parenting parents among the parents, especially with pre-schoolers who are more demanding. There is a need to address parents’ concerns and train them to deal with the situations effectively.