bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contesting ‘Global Sisterhood’: The Global Women's Health Movement, the United Nations and the Different Meanings of Reproductive Rights (1970s–80s)
Authors: Bracke Maud Anne 
Published: July 2023

AbstractThe article contributes to a genealogy of the global articulation of reproductive rights principles, as established at the 1994 United Nations (UN) Conference on Population and Development held in Cairo and the UN Women's Conference held in Beijing the following year. It highlights the key role played by an emerging global women's health movement in the 1970s–80s, in shaping UN debates on family planning, women's rights in procreative choice and women's roles in socio‐economic development. The article focuses on the International Campaign for Abortion, Sterilisation and Contraception (est. London 1978) and the Women's Global Network for Reproductive Rights (Amsterdam and Manila 1984; ECOSOC consultative status in 1992). Adopting an intersectional perspective, the paper highlights the local embeddedness of feminist positions, the shortcomings of Western feminism and the ways in which conflicts between women's organisations allowed for an original and evolving concept of reproductive rights to emerge. It is based on UN papers and the archives of the above organisations and family planning movements.
Meiotic abnormalities in sugarcane (Saccharum spp.) and parental species: Evidence for peri‐ and paracentric inversions
Authors: Oliveira Gleicy Kelly , Soares Nina Reis , Costa Zirlane Portugal , Almeida Carmelice Boff , Machado Raquel Moura , Mesquita Amanda Teixeira , Carneiro Monalisa Sampaio , Forni‐Martins Eliana R. , Mondin Mateus , Vieira Maria Lucia Carneiro 
Published: July 2023

AbstractThe modern cultivars of sugarcane (Saccharum spp.) are highly polyploid and accumulate aneuploidies due to their history of domestication, genetic improvement and interspecific hybrid origin involving the domesticated sweet species Saccharum officinarum (‘noble cane’) and the wild Saccharum spontaneum, both with an evolutionary history of polyploidy. The first hybrids were backcrossed with S. officinarum, and selection from progenies in subsequent generations established the genetic basis of modern cultivars. Saccharum genome complexity has inspired several molecular studies that have elucidated aspects of sugarcane genome constitution, architecture and cytogenetics. Herein, we conducted a comparative analysis of the meiotic behaviour of representatives of the parentals S. officinarum and S. spontaneum, and the commercial variety, SP80‐3280. S. officinarum, an octoploid species, exhibited regular meiotic behaviour. In contrast, S. spontaneum and SP80‐3280 exhibited several abnormalities from metaphase I to the end of division. We reported and typified, for the first time, the occurrence of peri‐ and paracentric inversions. Using in‐situ hybridisation techniques, we were able to determine how pairing association occurred at diakinesis, the origin of lagging chromosomes and, in particular, the mitotic chromosome composition of SP80‐3280. Interestingly, S. spontaneum and recombinant chromosomes showed the most marked tendency to produce laggards in both divisions. Future attempts to advance knowledge on sugarcane genetics and genomics should take meiotic chromosome behaviour information into account.
Time trends and projections in the prevalence of gestational diabetes mellitus in Queensland, Australia, 2009–2030: Evidence from the Queensland Perinatal Data Collection
Authors: Alwash Sura M. , Huda M. Mamun , McIntyre H. David , Mamun Abdullah A. 
Published: July 2023

BackgroundGestational diabetes mellitus (GDM) is the fastest‐growing type of diabetes in Australia. We aimed to assess the time trends during 2009–2018 and projections of GDM in Queensland, Australia up to 2030.Materials and MethodsThe study data were from the Queensland Perinatal Data Collection (QPDC) and included data on 606 662 birth events with the births reported from at least 20 weeks gestational age or birth weight at least 400 g. Bayesian regression model was used to assess the trends in the prevalence of GDM.ResultsThe prevalence of GDM increased from 5.47 to 13.62% from 2009 to 2018 (average annual rate of change, AARC = +10.71%). If the trend remains the same, the projected prevalence will increase to 42.04% (95% uncertainty interval = 34.77–48.96) by 2030. Observing AARC across different subpopulations, we found that the trend of GDM increased markedly among women living in inner regional areas (AARC = +12.49%), were non‐Indigenous (AARC = +10.93%), most disadvantaged (AARC = +11.84%), aged either of two age groups (AARC = +18.45% and + 15.17% for <20 years and 20–24 years, respectively), were with obesity (AARC = +11.05%) and smoked during pregnancy (AARC = +12.26%).ConclusionsOverall, the prevalence of GDM has sharply increased in Queensland, and if this trend continues, about 42% of pregnant women will experience GDM by 2030. The trends vary across different subpopulations. Therefore, targeting the most vulnerable subpopulations is vital to prevent the development of GDM.
Direct oral anticoagulants (DOACs) use for prolonged venous thromboembolism prophylaxis following surgery for gynaecological malignancies in Australia and New Zealand – A clinician survey
Authors: Boo Marilyn , Simcock Bryony , Sykes Peter , Brand Alison 
Published: July 2023

BackgroundCurrent international guidelines recommend 28 days of enoxaparin as venous thromboembolism (VTE) prophylaxis after surgery for gynaecologic cancer. Direct oral anticoagulants (DOACs) have been investigated as an alternative to enoxaparin for post‐operative VTE prophylaxis. High‐quality evidence to demonstrate safety and efficacy is lacking.AimsWe aim to investigate the current practice regarding VTE prophylaxis among gynaecological oncologists in Australia and New Zealand following laparotomy for gynaecological malignancy, in particular the use of DOACs for VTE prophylaxis.Materials and MethodsSixty‐seven practising gynaecologic oncologists (GO) were identified through Royal Australia and New Zealand College of Obstetricians and Gynaecologists database and emailed online surveys that asked about VTE prophylaxis practice and views of DOACs in this setting. Data were then collected through Survey Monkey and evaluated.ResultsThe majority (77.1%) routinely prescribed 28 days of enoxaparin following laparotomy for gynaecological malignancies. In clinical circumstance such as laparoscopy for gynaecological malignancies and surgery for vulva malignancies, there was variation in thromboprophylaxis practices. No GO reported routine use of DOACs in any clinical circumstance. There were 56% of GOs who used a DOAC in their practice at some point. Barriers to routine use of DOACs in current practice included insufficient evidence (68%), issue with cost (40.4%) and concerns about safety (29.7%).ConclusionsEnoxaparin prescribed for 28 days remains the current clinical practice in preventing VTE following laparotomy for gynaecological malignancy. The main barrier to routine DOAC use as post‐operative thromboprophylaxis is a lack of evidence which reflects the need for a larger prospective study.
Phacoemulsification with gonioscopy‐assisted transluminal trabeculotomy versus phacoemulsification alone in primary angle closure glaucoma: A randomized controlled study
Authors: El Sayed Yasmine Mohamed , Mettias Nader Momtaz , Elghonemy Hanan Mohyi Eldin , Mostafa Yehia Salah Eldin 
Published: July 2023

AbstractPurposeTo assess the safety and efficacy of combining phacoemulsification with gonioscopy‐assisted transluminal trabeculotomy (GATT) compared to phacoemulsification alone in the management of primary angle closure glaucoma (PACG).MethodsProspective, institutional study in which eyes requiring surgery for PACG were randomized to undergo phacoemulsification followed by GATT (phaco‐GATT group) or phacoemulsification alone. Success was defined as having a final IOP of 6–20 mmHg with no subsequent glaucoma surgery or vision‐threatening complications.ResultsThirty‐six eyes underwent phaco‐GATT with 360° angle incision and 38 eyes underwent phacoemulsification alone. IOP and glaucoma medications were significantly lower in the phaco‐GATT group at 1, 3, 6, 9 and 12 months. The success rate in the phaco‐GATT group was 94.4% after 12.16 ± 2.03 months, with 75% of eyes being off medications compared to 86.8% after 12.47 ± 4.27 months in the phaco group, with 42.1% off medications. (p = 0.008). Hyphema and fibrinous anterior chamber reaction were the most common complications in the phaco‐GATT group and resolved with conservative treatment or required YAG capsulotomy. Although this delayed visual rehabilitation in the phaco‐GATT group, it did not affect the final visual outcome with no significant difference in the final best‐corrected visual acuity between both groups (p = 0.25).ConclusionCombining phacoemulsification with GATT in PACG yielded more favourable outcomes in terms of IOP, glaucoma medications and surgical success. Although the postoperative hyphema and fibrinous reaction may delay visual rehabilitation, GATT further lowers the IOP by breaking residual peripheral anterior synechiae and removing the dysfunctional trabeculum circumferentially, while avoiding the risks inherent in more invasive filtering procedures.
When telework is a burden rather than a perk: The roles of knowledge sharing and supervisor social support in mitigating adverse effects of telework during the COVID‐19 pandemic
Authors: Hodzic Sabina , Prem Roman , Nielson Caroline , Kubicek Bettina 
Published: July 2023

AbstractDue to increased telework as a result of the COVID‐19 pandemic, the literature has called for exploring the impacts of imposed telework on work‐ and well‐being‐related outcomes. To answer this call, we investigated the effects of the amount of telework on perceived productivity, work engagement, and social isolation during the beginning of the pandemic. Moreover, leaning on self‐determination theory, we examined the role of knowledge sharing as an underlying mechanism and supervisor social support as a buffer for these effects. Using a weekly diary study, we gathered 847 datasets from 167 individuals. Results revealed negative correlations of telework with productivity and engagement and a positive correlation with social isolation. Knowledge sharing positively related to the outcomes but did not mediate the effects of telework on them. However, supervisor social support did moderate the relationship between telework and knowledge sharing. With very low‐level supervisor social support, large amounts of telework were accompanied by reduced knowledge sharing. Hence, imposed telework during the pandemic acted as a burden. If supervisors failed to provide social support, telework was associated with less productivity and work engagement but greater social isolation via reduced knowledge sharing. Supervisors should adjust their behavior and support knowledge sharing in imposed telework arrangements.
Relational approaches in bioethics: A guide to their differences
Authors: Gary Mercer 
Published: July 2023

AbstractContemporary critical approaches to bioethics increasingly present themselves as “relational,” though the meaning of relationality and its implications for bioethics seem to be many and varying. I argue that this confusion is due to a multiplicity of relational approaches originating from distinct theoretical lineages. In this article, I identify four key differences among commonly referenced relational approaches: the scope and nature of relationships considered, the extent of the determining influence on individual selfhood, and the integrity of individual selfhood. Importantly, these four differences carry consequences for the usage of relational approaches within academic and clinical bioethics. I show that these differences attach to multiple objects of critique within mainstream bioethics and imply distinct metaethical commitments. Although I issue a cautionary note about combining relational approaches from distinct lineages, I close by suggesting that many such approaches may have their use, drawing on Susan Sherwin's sense of bioethical theories as lenses.
Development of a metacognitive regulation‐based collaborative programming system and its effects on students' learning achievements, computational thinking tendency and group metacognition
Authors: Li Wei , Liu Cheng‐Ye , Tseng Judy C. R. 
Published: July 2023

AbstractCollaborative programming helps improve students' computational thinking and increases their confidence in solving programming problems. However, the effect of collaborative learning is not ideal because it is difficult for students to mobilize metacognition to regulate learning spontaneously. To guide students to effectively regulate the learning process when they collaborate to solve programming problems, this study develops a collaborative learning approach and a Collaborative programming System (MR‐CPS) based on metacognitive regulation to support students' collaborative programming learning. A quasi‐experimental study was conducted in a junior high school programming course in Taiwan to assess the effects on students. The impacts of MR‐CPS from both individual and collaborative perspectives were investigated. Students' learning achievement and computational thinking tendencies were examined from an individual perspective. From a collaborative perspective, group self‐efficacy and group metacognition were investigated. Participants were divided into MR‐CPS (n = 115) and No‐MR‐CPS (n = 107). The MR‐CPS group used the collaborative programming approach with metacognitive regulation mechanisms as the experimental group. In contrast, the No‐MR‐CPS group used the collaborative programming approach without metacognitive regulation mechanisms as the control group. The results show that the MR‐CPS group statistically significantly outperformed the No‐MR‐CPS group in learning achievements. It was also found that the MR‐CPS group had statistically significantly better computational thinking tendency, collective efficacy and metacognitive planning and evaluation skills than the No‐MR‐CPS group. This finding suggests that the MR‐CPS has the potential to improve students' learning achievements, computational thinking tendency, group metacognition and collective efficacy. The study results have implications for the design of collaborative programming systems consistent with metacognitive regulation.
Dasatinib plus prednisone as induction and consolidation for adults with Ph‐positive acute lymphoblastic leukaemia: A single‐arm, multicentre, phase 2 trial
Authors: Xie Mixue , Lu Ying , Ouyang Guifang , Li Xueying , Shi Ting , Yang Min , Le Jing , Hu Huixian , Zhang Li , Feng Weiying , Meng Haitao , Mai Wenyuan , Wei Juying , Qian Jiejing , Xu Gaixiang , Yang Chunmei , Zhou De , Lin Yin , Qian Suying , Kuang Yuemin , Zhang Liming , Zhu Weiguo , Yao Guoli , Wu Gongqiang , Hu Shao , Huang Xin , Wang Yungui , Tong Hongyan , Jin Jie , Zhu Hong‐Hu 
Published: July 2023

SummaryTo reducing chemotherapy‐related toxicity, the chemo‐free regimens become a new trend of Ph + ALL treatment. Therefore, we conducted a phase 2 trial of dasatinib plus prednisone, as induction (Course I) and early consolidation (Courses II and III) treating newly diagnosed Ph + ALL. The trial was registered at www.chictr.org.cn, ChiCTR2000038053. Forty‐one patients were enrolled from 15 hospitals. The complete remission (CR) was 95% (39/41), including two elderly induction deaths. By the end of Course III, 25.6% (10/39) of patients achieved a complete molecular response. With a median follow‐up of 15.4 months, 2‐year disease‐free survival (DFS) were 100% and 33% for patients who receiving haematopoietic stem cell transplantation (HSCT) at CR1 and receiving chemotherapy alone respectively. When censored at time of HSCT, 2‐year DFS were 51% and 45% for young and elderly patients (p = 0.987). 2‐year overall survival were 45%, 86% and 100% for patients without HSCT, receiving HSCT after relapse and receiving HSCT at CR1 respectively. A total of 12 patients had marrow recurrences and one had CNS relapse, with 38% occurred early (between Courses I and III). IKZF1 gene deletion was shown to be associated with relapse (p = 0.019). This chemo‐free induction and early consolidation regimen was efficacious and well‐tolerated in de novo Ph + ALL. Allogeneic HSCT conferred definite survival advantage after chemo‐free induction.
Targeting emotional regulation using an Internet‐delivered psychological intervention for cancer survivors: A randomized controlled trial
Authors: Smith Isabelle S. , Bind Marie‐Abèle , Weihs Karen L. , Bei Bei , Wiley Joshua F. 
Published: July 2023

AbstractObjectivesThis trial assessed the efficacy of an emotion‐focused, modular, Internet‐delivered adaptation of the Unified Protocol (UP) in improving cancer survivors' emotion regulation strategies.DesignA two‐arm randomized controlled trial (1:1) was used to compare the efficacy of two Internet‐based interventions: UP‐adapted CanCope Mind (CM) and lifestyle‐focused active control CanCope Lifestyle (CL).MethodsN = 224 cancer survivors randomized to CM or CL were assessed at baseline, between‐modules, at post‐intervention and 3‐month follow‐up on emotion regulation outcomes targeted by each CM module (Module 1: beliefs about emotions; Module 2: mindfulness; Module 3: cognitive reappraisal skills, catastrophizing, refocus on planning; Module 4: experiential avoidance). Primary analyses were intention‐to‐treat linear regressions using Fisher randomization tests for p‐values and intervals were used to compare groups with standardized mean difference (SMD) effect sizes.ResultsCanCope Mind participants (n = 61 completers) experienced moderate‐to‐large improvements (SMDs from .44–.88) across all outcomes at post‐intervention. CM's effects were larger than CL's (n = 75 completers) immediately post‐intervention and at 3‐month follow‐up for beliefs about emotions, mindfulness, cognitive reappraisals and experiential avoidance (all p's < .05). CM experienced greater improvements in catastrophizing immediately post‐intervention, with a trending effect at follow‐up. However, we could not reject the null hypothesis of identical between‐group effects for refocusing on planning both immediately post‐intervention and at follow‐up. Exploratory analyses revealed inconsistent between‐module effects.ConclusionsIn its entirety, CM is a promising intervention for improving and maintaining cancer survivors' adaptive emotion regulation, especially for mindfulness and experiential avoidance. This may have important clinical implications for promoting cancer survivors’ emotional functioning and general well‐being.
Diagnosis, treatment, and survival from kidney cancer: real‐world National Health Service England data between 2013 and 2019
Authors: Conroy Samantha , Catto James W.F. , Bex Axel , Brown Janet E. , Cartledge Jon , Fielding Alison , Jones Rob J. , Khoo Vincent , Nicol David , Stewart Grant D. , Sullivan Mark , Tran Maxine G.B. , Woodward Rose , Cumberbatch Marcus G. 
Published: July 2023

ObjectivesTo report the NHS Digital (NHSD) data for patients diagnosed with kidney cancer (KC) in England. We explore the incidence, route to diagnosis (RTD), treatment, and survival patterns from 2013 to 2019.Materials and MethodsData was extracted from the Cancer Data NHSD portal for International Classification of Diseases, 10th edition coded KC; this included Cancer Registry data, Hospital Episode Statistics, and cancer waiting times data.ResultsRegistrations included 66 696 individuals with KC. Incidence of new KC diagnoses increased (8998 in 2013, to 10 232 in 2019), but the age‐standardised rates were stable (18.7–19.4/100 000 population). Almost half of patients (30 340 [45.5%]) were aged 0–70 years and the cohort were most frequently diagnosed with Stage 1–2 KC (n = 26 297 [39.4%]). Most patients were diagnosed through non‐urgent general practitioner referrals (n = 16 814 [30.4%]), followed by 2‐week‐wait (n = 15 472 [28.0%]) and emergency routes (n = 11 796 [21.3%]), with older patients (aged ≥70 years), Stage 4 KCs, and patients with non‐specified renal cell carcinoma being significantly more likely to present through the emergency route (all P < 0.001). Invasive treatment (surgery or ablation), radiotherapy, or systemic anti‐cancer therapy use varied with disease stage, patient factors, and treatment network (Cancer Alliance). Survival outcomes differed by Stage, histological subtype, and social deprivation class (P < 0.001). Age‐standardised mortality rates did not change over the study duration, although immunotherapy usage is likely not captured in this study timeline.ConclusionThe NHSD resource provides useful insight about the incidence, diagnostic pathways, treatment, and survival of patients with KC in England and a useful benchmark for the upcoming commissioned National Kidney Cancer Audit. The RTD data may be limited by incidental diagnoses, which could confound the high proportion of ‘emergency’ diagnoses. Importantly, survival outcomes remained relatively unchanged.
Brigatinib in Japanese patients with ALK‐positive non‐small‐cell lung cancer: Final results of the phase 2 J‐ALTA trial
Authors: Yoshida Tatsuya , Kumagai Toru , Toyozawa Ryo , Katayama Ryohei , Nishio Makoto , Seto Takashi , Goto Koichi , Yamamoto Nobuyuki , Ohe Yuichiro , Kudou Kentarou , Asato Takayuki , Zhang Pingkuan , Nakagawa Kazuhiko 
Published: July 2023

AbstractThe phase 2, single‐arm, multicenter, open‐label J‐ALTA study evaluated the efficacy and safety of brigatinib in Japanese patients with advanced ALK+ non‐small‐cell lung cancer (NSCLC). One expansion cohort of J‐ALTA enrolled patients previously treated with ALK tyrosine kinase inhibitors (TKIs); the main cohort included patients with prior alectinib ± crizotinib. The second expansion cohort enrolled patients with TKI‐naive ALK+ NSCLC. All patients received brigatinib 180 mg once daily (7‐day lead‐in at 90 mg daily). Among 47 patients in the main cohort, 5 (11%) remained on brigatinib at the study end (median follow‐up: 23 months). In this cohort, the independent review committee (IRC)‐assessed objective response rate (ORR) was 34% (95% CI, 21%–49%); median duration of response was 14.8 months (95% CI, 5.5–19.4); median IRC‐assessed progression‐free survival (PFS) was 7.3 months (95% CI, 3.7–12.9). Among 32 patients in the TKI‐naive cohort, 25 (78%) remained on brigatinib (median follow‐up: 22 months); 2‐year IRC‐assessed PFS was 73% (90% CI, 55%–85%); IRC‐assessed ORR was 97% (95% CI, 84%–100%); the median duration of response was not reached (95% CI, 19.4–not reached); 2‐year duration of response was 70%. Grade ≥3 adverse events occurred in 68% and 91% of TKI‐pretreated and TKI‐naive patients, respectively. Exploratory analyses of baseline circulating tumor DNA in ALK TKI‐pretreated NSCLC showed associations between poor PFS and EML4‐ALK fusion variant 3 and TP53. Brigatinib is an important treatment option for Japanese patients with ALK+ NSCLC, including patients previously treated with alectinib.