bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central activation of the fatty acid sensor GPR120 suppresses microglia reactivity and alleviates sickness-and anxiety-like behaviors
Authors: Nakajima Shingo , Demers Geneviève , Machuca-Parra Arturo Israel , Pour Zahra Dashtehei , Bairamian Diane , Bouyakdan Khalil , Fisette Alexandre , Kabahizi Anita , Robb Josephine , Rodaros Demetra , Laurent Cyril , Ferreira Guillaume , Arbour Nathalie , Alquier Thierry , Fulton Stephanie 
Published: July 2023

Abstract
G protein-coupled receptor 120 (GPR120, Frar4) is a sensor for long-chain fatty acids including omega-3 polyunsaturated fatty acids (n-3 PUFAs) known for beneficial effects on inflammation, metabolism, and mood. GPR120 mediates the anti-inflammatory and insulin-sensitizing effects of n-3 PUFAs in peripheral tissues. The aim of this study was to determine the impact of GPR120 stimulation on microglial reactivity, neuroinflammation and sickness- and anxiety-like behaviors by acute pro-inflammatory insults. We found higher GPR120 mRNA expression in microglia as compared to neurons and astrocytes in both murine and human isolated neural cells, and in situhybridization revealed GPR120 expression in microglia in mouse brain. In a manner similar to or exceeding n-3 PUFAs, GPR120 agonism (Compound A, CpdA) strongly attenuated lipopolysaccharide (LPS)-induced proinflammatory marker expression in primary mouse microglia, including tumor necrosis factor-α (TNF-α) and interleukin-1b (IL-1b), and inhibited nuclear factor-ĸB translocation to the nucleus. Central administration of CpdA to adult mice blunted LPS-induced hypolocomotion and anxiety-like behavior and reduced TNF-α, IL-1β and IBA-1 (microglia marker) mRNA in the nucleus accumbens (NAc), a brain region modulating anxiety and motivation and implicated in neuroinflammation-induced mood deficits. GPR120 agonist pre-treatment attenuated NAc microglia reactivity and alleviated sickness-like behaviors elicited by central injection TNF-α and IL-1b. These findings suggest that microglial GPR120 contributes to neuroimmune regulation and behavioral changes in response to acute infection and elevated brain cytokines. GPR120 may participate in the protective action of n-3 PUFAs at the neural and behavioral level and offers potential as treatment target for neuroinflammatory conditions.
The Impact of a Seven-Week Heart Rate Variability Biofeedback Protocol on Skin Severity, Quality of Life, and Mental Health in a Proof-of-Concept Clinical Case Series of Individuals with Psoriasis
Authors: Park Sarah JaeHwa , Fox Devon J. , Young Lee H. , Roth Maya , Khamba Baljit 
Published: July 2023

Abstract
Background
Psoriasis is a common psychocutaneous disorder, frequently associated with reduced quality of life (QoL) and psychiatric comorbidities, including anxiety and mood disorders. Although pharmacological interventions and phototherapy may provide effective, albeit temporary, relief in the skin, they frequently fail to address the psychological impact of the disease. Heart rate variability biofeedback (HRVB) is a specific mind-body therapy that provides real-time visual feedback on an individual’s autonomic functioning in order to modify their physiological stress response through diaphragmatic, paced breathing.
Objective
To explore the impact of a seven-week HRVB protocol on skin severity (SS), QoL, and mental health (MH) in individuals with psoriasis and to determine whether the effects, if any, can be maintained after the intervention has concluded.
Methods
This was a single-arm, proof-of-concept clinical case series conducted at Bastyr University Clinic in San Diego, California. Five participants were recruited through flyers and referrals and were screened for eligibility prior to undergoing a seven-week HRVB protocol. SS was assessed by both the participant and clinician using the Psoriasis Area and Severity Index (PASI-P and PASI-C), QoL was assessed using the Cardiff Dermatology Life Quality Index (DLQI), and MH was measured using the Generalized Anxiety Disorder-7 (GAD-7), and the Patient Health Questionnaire-9 (PHQ-9). These outcomes were collected at baseline (T1), post-protocol (T2), and follow-up (T3) between June 2022 to December 2022.
Results
There were significant differences in scores between T1 and T2 for PASI-P, DLQI, and GAD-7. There was also a significant difference between T1 and T3 for GAD-7. PASI-C and PHQ-9 had no significant difference between any time points. All scales were non-significant for T2 and T3. PASI-P, PASI-C, DLQI, and PHQ-9 were non-significant between T1 to T3. Linear regressions for each participant showed a majority decreasing rate of change.
Conclusion
In this real-life setting, HRVB was associated with significant improvements in participant perception of SS, QoL, and anxiety over a seven-week period. Future studies should include a larger cohort with more variation in SS, QoL, and MH scores at T1 and compare the HRVB protocol against a control group. NCT05506644, retrospectively registered on 16 August 2022.
Trial registration
ClinicalTrials.gov
The Willingness and Influencing Factors to Choose Institutional Elder Care Among Rural Elderly: An Empirical Analysis Based on the Survey Data of Shandong Province
Authors: Xu Xinglong , Li Peiyao , Ampon-Wireko Sabina 
Published: July 2023

Abstract
Background: The ageing of the population has become an escalating problem in China, which has led to an increasing demand for healthcare throughout society. The care services of elderly institutions, as a more mature way of aging, can alleviate various social problems brought about by ageing to a certain extent. The aim of this paper is to explore the degree of acceptance of institutional care by rural elderly people in Shandong Province and the factors that influence whether rural elderly people accept institutional care services.
Methodology: Based on Maslow's hierarchy of needs theory, this paper constructs an analytical framework that influences rural elderly people's willingness to accept institutional care. Using survey data from 192 older people in rural Shandong province, descriptive statistics, binary logistic regression and heterogeneity analysis were conducted to analyse the willingness of rural older people to age in an elderly care institution and the factors influencing them.
Results: Only 17.71% of the respondents were willing to accept the services of an aged-care institution. Among them, literacy, annual household income, trust in elderly care institutions and children's support had a significant positive influence on whether rural elderly people accepted services in elderly care institutions; physical condition, marital status, number of children and knowledge of elderly care institutions had a significant negative influence on whether rural elderly people accepted care services in elderly care institutions.
Conclusion: The non-acceptance of institutional care by rural older people is a general phenomenon rather than a sample characteristic, thus justifying the supplementary status of institutional care services. Social circumstances such as lifestyle and ideology in particular constrain the willingness of rural older people to age in institutions. The state should strengthen public opinion guidance and education on the ageing situation to alleviate the constraints imposed by solidified traditional ideology on the willingness of rural older people to diversify their old age; encouraging older people to save and building warm and comfortable old age institutions can help to increase the willingness of rural older people to age in institutions.
Viral mimic polyinosine-polycytidylic acid promotes renal endothelial cell injury via HMGB1 acetylation in trichloroethylene-sensitized mice
Authors: Wang Feng , Hong Yi-Ting , Zang Dan-Dan , Cheng Rui-Xuan , Gao Ji-Hong , Chen Mu-Yue , Zhu Qixing 
Published: July 2023

Abstract
Viral infection or reactivation seems to be critical in trichloroethylene hypersensitivity syndrome (THS), which is also called occupational medicamentosa-like dermatitis (OMDT) in China. Our previous studies reported that polyinosinic-polycytidylic acid (poly I:C) amplified hepatitis in TCE-sensitized mice. However, whether poly I:C plays a role in TCE-induced renal damage remains to be clarified. To this end, a TCE-sensitized mouse model was established. Renal damage, especially renal endothelial cell dysfunction, was assessed. The activation of high mobility group box protein 1 (HMGB1) was further detected to elucidate the possible role of poly I:C in TCE sensitization-induced renal damage. Our results showed that poly I:C pretreatment aggravated the renal histological changes and dysfunction in TCE-sensitized mice. Renal endothelial cell injuries might be a key driver of kidney damage, in which poly I:C pretreatment acted as an amplifier in TCE sensitization. In addition, poly I:C, combined with Toll-like receptor (TLR) 3, promotes the acetylation and release of HMGB1 from renal endothelial cells. Taken together, our findings highlighted a novel role of poly I:C pretreatment in TCE sensitization-induced renal endothelial cell injuries.
A Deep Attentive Network for Music Emotion Recognition using the chorus part of the music
Authors: Talaghat Mohammad Ali , Parvinnia Elham , Boostani Reza , Mehrabi Mehdi 
Published: July 2023

Abstract
In the domain of music information retrieval, music emotion recognition (MER) is an active area of research. The chorus part of the music is the most critical and emotional section. In this paper, we proposed an MER approach that combines Convolutional Neural Networks with Long Short-Term Memory to extract emotional features from the log-mel spectrogram of the music chorus part. Then, the features feed into an attention mechanism block to enhance helpful information. Also, we introduce a new dataset for the MER task that consists of 10,438 samples with valence/arousal labels. The results show that using chorus parts of music can improve the deep models' performance. Also, experiments show our proposed method achieves 15% and 40% relative improvement of valence and arousal, respectively, on the R2 score compared to the state-of-the-art and baseline models.
A qualitative exploration of the determinants of youth violence using participatory action research: a Sri Lankan study
Authors: Rathnayake Nadeeka , Abhayasinghe Kalpani , De Silva Jayamal , Guruge G. N. Duminda 
Published: July 2023

Abstract
Background
Youth violence is a significant health issue mainly in low and middle-income countries (LMICs). Violence is growing among Sri Lankan youth, yet research addressing it has been almost non-existent. Various personal and environmental factors place youth at risk of violence. The present study aimed to identify the determinants of youth violence from the perspectives of students and key informants of a Sri Lankan technical college.
Methods
The current study used the participatory action research (PAR) approach. The study was conducted at a technical college in Matale district, Sri Lanka with a sample of 74 students. Participants were involved in developing the focus group discussion (FGD) guide and key informant interview (KII) guide, which were the methods of data collection. Four FGDs and seven KIIs were conducted until data saturation was achieved. Thematic analysis was used in the data analysis. Participants were engaged and involved in the data collection and analysis where necessary in line with the PAR principles.
Results
The determinants of youth violence identified in the current study are presented under five themes: 1. individual-level determinants, 2. family-level determinants, 3. school-level determinants, 4. determinants specific to the technical college, and 5. societal-level determinants. Individual-level determinants reported by participants included poor awareness, inability to bear being defeated, frequent victimization, unemployment, psychological stress, and substance abuse. Family-level determinants reported were poor parental affection, guidance and parenting skills, distorted family connections and family disruption, pressure on education, witnessing domestic violence as a child, and discrimination within the family. School-level determinants included school dropouts, peer influences, discrimination at school, and the competitive education system. Furthermore, participants described subculture and diversity among students as determinants specific to the technical college. Societal-level determinants identified by participants included social discrimination, disadvantage, disparity and inequity, increase in the requirements and change in the goals of youth, justification, glamorization and normalization of violence, gaps in law enforcement, socio-political instabilities and the rise of inflation.
Conclusions
The PAR approach facilitated the identification of a variety of individual, family, school, and societal-level determinants of youth violence which may contribute to addressing violence in tertiary education institutes in Sri Lanka and other LMICs.
Uncovering the genomic regions associated with yield maintenance in rice under drought stress using an integrated meta-analysis approach
Authors: Daryani Parisa , Ramandi Hadi Darzi , Amirbakhtiar Nazanin , Soorni Jahad , Loni Fatemeh , Shobbar Zahra-Sadat 
Published: July 2023

Abstract
The complex trait of yield is controlled by quantitative trait loci (QTLs). Considering the global water deficit problem, rice varieties that are suitable for non-flooded cultivation are of great importance in breeding programs. The powerful approach of Meta-QTL (MQTL) analysis can be used for the genetic dissection of complicated quantitative traits. A comprehensive MQTL analysis was done to detect consistent QTL regions associated with drought tolerance and yield-related traits under water deficit conditions in rice. Totally, 1087 QTLs from 134 rice populations published from 2000 to 2021 were utilized in the analysis. Distinct MQTL analysis of the related traits led to the identification of 213 stable MQTLs. The confidence interval (CI) of the detected MQTLs was between 0.12 and 19.66 cM. In comparison with the CI mean of the initial QTLs, the CI mean of the identified MQTLs (4.68 cM) was 2.74 times narrower. Remarkably, 63 MQTLs overlapped with SNP peak positions detected by genome-wide association studies (GWAS) for yield and drought tolerance-associated traits under water deficit conditions in rice. Considering the genes located both in the SNP peak positions and QTL-overview peaks, 19 genes were introduced as novel candidate genes, which are associated with drought response index, plant height, panicle number, biomass, and grain yield. On the other hand, an inclusive MQTL analysis was performed on all the traits to obtain “Breeding MQTLs”. Performing inclusive MQTL analysis on all the traits resulted in the identification of 96 MQTLs with a CI ranging from 0.01 to 9 cM. The CI mean of the obtained MQTLs was 2.33 cM, which was 4.66 times narrower than the CI mean of the initial QTLs. Thirteen MQTLs having more than 10 initial QTLs, CI < 1 cM, and a PVE mean of the initial QTLs > 10 were identified as “Breeding MQTLs”. We hope that the obtained results can help breeders to enhance rice yield under drought stress conditions.
Generation climate crisis, COVID-19, and Russia-Ukraine- War– Global crises and mental health in adolescents
Authors: Lass-Hennemann Johanna , Sopp M. Roxanne , Ruf Norma , Equit Monika , Schäfer Sarah K. , Wirth Benedikt E. , Michael Tanja 
Published: July 2023

Abstract

Climate change, Covid-19, and the Russia-Ukraine war are some of the great challenges of our time. These global crises affect young people in a particularly vulnerable phase of their lives. The current study aimed to assess the impact of these crises on mental health (depression, anxiety, and health-related quality of life) in secondary school students in Germany. Furthermore, we assessed known predictors of mental health, such as socio-economic factors, individual life stressors, and resilience factors (self-efficacy, expressive flexibility) as covariates. In our sample of 4001 pupils, pandemic- and climate-related distress were linked to greater depression and anxiety and reduced health-related quality of life. War-related distress was associated with greater anxiety. Critically, these associations remained significant after controlling for all covariates, supporting incremental predictive value of the crises measures. The study reveals a significant impact of the crises on mental health of the current generation of adolescents. As such it suggests that mental health policies should include interventions that help youth to cope with the stress caused by the crises.
Has the educational progress in China exacerbated the deviation of fertility intention from fertility behavior?
Authors: Zhang Chong , Jiang Shilin , Li Muzhi , Shi Xiaoyang 
Published: July 2023

Abstract
The discrepancy between fertility intentions and fertility behavior has been a common occurrence, yet there is no consensus regarding the impact of education on fertility deviations and the underlying mechanisms. Drawing on data from the Chinese General Social Survey (CGSS) conducted in 2017, this study examines the influence of education on fertility deviations and investigates the mediating mechanisms through which education affects such deviations. The findings reveal that the relationship between education and fertility deviation is not simply linear.The individuals with both lower and higher levels of education are prone to deviate from their intended fertility, but in contrasting ways. Those with lower level of education tend to exhibit lower fertility intentions compared to their actual fertility behavior, whereas the reverse is observed among individuals with higher education levels. As educational attainment increases, the phenomenon of fertility intentions surpassing actual behavior becomes more pronounced. The stepwise regression analysis of the mediating effect and the results of the KHB decomposition demonstrate that personal income and age of first marriage serve as mediators in the educational influence on fertility deviation, with the latter playing a particularly significant role. Based on these findings, the following recommendations are proposed: shortening the duration of compulsory education and lower the legal age of marriage; redefine the concept of educational involution and decrease the financial burden of children's education; promote balanced development of basic education and bridge the educational disparities between urban and rural areas.
Energy Management Strategy for Dc Micro-grid System With an Important Penetration of Renewable Energy
Authors: Bipongo Christian Ndeke , Adonis Marco , Almaktoof Ali 
Published: July 2023

Abstract
This paper presents an energy management strategy using stateflow controller related to DC micro-grids with an important penetration of renewable energy. The increase in world electricity demand is one of the principal drivers of the exhaustion of fossil fuels and expanded greenhouse gas emissions. To solve these problems, several countries have adopted actions for large renewable energy deployment, which includes wind energy, solar power, biomass power, tidal, and hydropower. These sources are considered as significant in delivering clean energy and reducing greenhouse gas emissions for sustainable improvement. In such a case, these are referred to as distributed generation systems. Distributed generation can impact negatively on the performance of the distribution network as the distribution network will no longer operate with a unidirectional power flow pattern. To address these issues, micro-grids are being used as a platform to integrate distributed generation systems, as they provide significant benefits to end-users and to the distribution network. The objective of this paper was to implement an energy management system to ensure the proper operation of the developed DC microgrid and this was developed using Simulink blocks available in the MATLAB/Simulink software. The simulation results shown that this control strategy is unconditionally reliable to ensure proper operation of the microgrid systems. Moreover, the developed algorithm model presents another advantage, which enables the users to access and to change any control parameters within the DC microgrid. By comparing these results with the literature, the developed energy management algorithm provides safety and automatic control of the microgrid.
Birthweight Trends and their Explanatory Factors in Hungary between 1999 and 2018: An Analysis of the Hungarian Tauffer Registry
Authors: ZSIRAI László , KUN Attila , VISOLYI Gergely Á. , SVÉBIS Márk M. , DOMJÁN Beatrix A. , Tabák Ádám Gy. 
Published: July 2023

Abstract
Background
The increasing birthweight trend stopped and even reversed in several high income countries in the last 20 years, however the reason for these changes is not well characterized. We aimed to analyze the birthweight trends of term deliveries and their potential maternal and fetal drivers in Hungary.
Methods
We analyzed data from the Hungarian Tauffer registry, a compulsory anonymized data collection of each delivery. We included all singleton term deliveries between in 1999-2018 (n=1 591 932). We modeled birthweight trends separately in 1999-2008 and 2008-2018 in hierarchical multiple linear regression models adjusted for calendar year, newborn sex, maternal age, gestational age at delivery, and other important determinants.
Results
Median birthweights increased from 3250/3400g (girl/boy) to 3300/3440g from 1999 to 2008 and decreased to 3260/3400g in 2018. When we adjusted for gestational age at delivery the increase in the first period became more pronounced (5.4 g/year). During the second period, similar adjustment substantially decreased the rate of decline from 2.5 to 1.4g/year. Further adjustment for maternal age halved the rate of increase to 2.4g/year in the first period. During the second period, adjustment for maternal age had little effect on the estimate.
Conclusions
Our findings of an increasing birthweight trend (mostly related to the aging of the mothers) in 1999-2008 may forecast an increased risk of cardiometabolic diseases in offsprings born in this period. In contrast, the decreasing birthweight trends after 2008 may reflect some beneficial effects on perinatal morbidity. However, the long-term effect cannot be predicted, as the trend is mostly explained by the shorter pregnancies.