bluuebunny/crossref_metadata_2025_split huggingface dataset:
Image-based searches for pulsar candidates using MWA VCS data
Authors: Sett S. , Bhat N. D. R. , Sokolowski M. , Lenc E. 
Published: January 2023

Abstract
Pulsars have been studied extensively over the last few decades and have proven instrumental in exploring a wide variety of physics. Discovering more pulsars emitting at low radio frequencies is crucial to further our understanding of spectral properties and emission mechanisms. The Murchison Widefield Array Voltage Capture System (MWA VCS) has been routinely used to study pulsars at low frequencies and discover new pulsars. The MWA VCS offers the unique opportunity of recording complex voltages from all individual antennas (tiles), which can be off-line beamformed or correlated/imaged at millisecond time resolution. Devising imaged-based methods for finding pulsar candidates, which can be verified in beamformed data, can accelerate the complete process and lead to more pulsar detections. Image-based searches for pulsar candidates can reduce the number of tied-array beams required, increasing compute resource efficiency. Despite a factor of

$\sim$

4 loss in sensitivity, searching for pulsar candidates in images from the MWA VCS, we can explore a larger parameter space, potentially leading to discoveries of pulsars missed by high-frequency surveys such as steep spectrum pulsars, exotic binary systems, or pulsars obscured in high-time resolution time series data by propagation effects. Image-based searches are also essential to probing parts of parameter space inaccessible to traditional beamformed searches with the MWA (e.g. at high dispersion measures). In this paper we describe the innovative approach and capability of dual-processing MWA VCS data, that is forming 1-s visibilities and sky images, finding pulsar candidates in these images, and verifying by forming tied-array beam. We developed and tested image-based methods of finding pulsar candidates, which are based on pulsar properties such as steep spectral index, polarisation and variability. The efficiency of these methodologies has been verified on known pulsars, and the main limitations explained in terms of sensitivity and low-frequency spectral turnover of some pulsars. No candidates were confirmed to be a new pulsar, but this new capability will now be applied to a larger subset of observations to accelerate pulsar discoveries with the MWA and potentially speed up future searches with the SKA-Low.
Harnessing Backlash: How Leaders Can Benefit from Antagonizing Foreign Actors
Authors: Matush Kelly 
Published: January 2023

AbstractLeaders nearly always claim that their diplomatic campaigns are intended to attract foreign support. However, many diplomatic campaigns fail spectacularly in this regard. While these events have largely been explained as diplomatic failures, I argue that alienating the apparent target of an international diplomatic campaign can be a deliberate strategy leaders use to win domestic support. Under certain conditions, a costly backlash from a foreign actor can be a credible signal that the leader shares the domestic audience's preferences. Therefore, by intentionally provoking a backlash from a valuable foreign actor, leaders can exchange foreign condemnation for an increase in domestic support. I support this argument with evidence from Netanyahu's 2015 speech to the US Congress. I show that, as expected by this theoretical framework, Netanyahu's efforts resulted in a significant backlash among US Democrats and a corresponding increase of support among right-wing Israelis, a crucial constituency for his upcoming election.
Marker-assisted selection for improving body weight in local chickens in Egypt
Authors: Helal M. M. , El-Gendy E. A. 
Published: January 2023

AbstractThere is a need for a low-cost strategy that accelerates the genetic change in local chicken breeds. Therefore, the objective of this study is to develop a strategy for marker-assisted selection for growth in local chickens in the developing countries. The studied lines were a homozygous normally feathered selected line (CE1), homozygous naked-neck selected line (CE3) and their corresponding control lines (CE2 and CE4). Lines CE1 and CE3 have been selected for high 6-week body weight (BW) for five generations. Three generations were obtained for this study. In the current study, we consider the 6th generation as the base generation for marker-assisted selection study. Two subsequent selected generations were obtained from the base generation. The selected lines were significantly heavier at 6 weeks of age than their corresponding control lines by 24.15 and 27.07% in the base generation and by 51.4 and 34.5% in the second selected generation. A total of 34 polymorphic alleles in 19 loci were flown over generations and the flow trends were different in different lines and families within lines. Principal component analysis was applied to the data of both lines and two main components were found and three canonical correlations were obtained. Four and five alleles were persistently concomitant with the highly performed families in lines CE1 and CE3, respectively. These alleles would have brought 6-week BW into higher levels of performance by 25.1 and 16.6% in the second generation if they would have been considered in the selection for 6-week BW.
Rethinking the Current “Stage-and-Wait” Paradigm
Authors: Ragoler Morel , Radomislensky Irina , Dolev Eran , Renert Liran , Peleg Kobi 
Published: January 2023

AbstractIntroduction:The experience of terrorist incidents involving a secondary explosive device that targeted rescue forces led to changes in the safety protocols of these forces in most countries of the world. These protocols are the foundation of the current “Stage-and-Wait” paradigm that prohibits the entry of Emergency Medical Services (EMS) from entering the scene and treating casualties until it is deemed safe. These guidelines were established absent of an evidence-base detailing the risk to responders and the potential consequences to the injured on-scene. The lack of clarity is compounded by the fact that different situations, as well as operational considerations, such as the length of time until bomb squad arrival at the scene versus time of massive bleeding injuries, for example, impact outcomes must be taken into account.Objective:This study sought to shed light on this matter while employing an evidence-based approach exploring the investigations of the frequency of secondary explosion threats in terrorist attacks over the last 20 years and discussing some of the ethical challenges and ramifications ensuing. While this study does not propose an outright change to current guidelines, in light of the evidence gathered, an open review and discussion based on the findings may be beneficial.Methods:The Global Terrorism Database (GTD) was used as the data source of bombing incidents world-wide.Results:The results revealed that approximately 70 per-1,000 bombing incidents involved secondary explosions across regions and countries within the study period.Conclusion:This study emphasizes the need to rethink the current “Stage-and-Wait” paradigm by recommending brainstorming conferences comprised of multi-sectoral experts aimed at deliberating the matter. World-wide experts in emergency medicine, bioethics, and disaster management should cautiously consider all aspects of bomb-related incidents. These brainstorming deliberations should consider the calculated risk of secondary explosions that account for approximately 70 per-1,000 bombing incidents. This study highlights the need to re-examine the current versus new paradigm to achieve a better balance between the need to ensure EMS safety while also providing the necessary and immediate care to improve casualty survival. This ethical dilemma of postponing urgent care needs to be confronted.
Closed genomes uncover a saltwater species of Candidatus Electronema and shed new light on the boundary between marine and freshwater cable bacteria
Authors: Sereika Mantas , Petriglieri Francesca , Jensen Thomas Bygh Nymann , Sannikov Artur , Hoppe Morten , Nielsen Per Halkjær , Marshall Ian P G , Schramm Andreas , Albertsen Mads 
Published: January 2023

Abstract
Cable bacteria of the Desulfobulbaceae family are centimeter-long filamentous bacteria, which are capable of conducting long-distance electron transfer. Currently, all cable bacteria are classified into two candidate genera: Candidatus Electronema, typically found in freshwater environments, and Candidatus Electrothrix, typically found in saltwater environments. This taxonomic framework is based on both 16S rRNA gene sequences and metagenome-assembled genome (MAG) phylogenies. However, most of the currently available MAGs are highly fragmented, incomplete, and thus likely miss key genes essential for deciphering the physiology of cable bacteria. Also, a closed, circular genome of cable bacteria has not been published yet. To address this, we performed Nanopore long-read and Illumina short-read shotgun sequencing of selected environmental samples and a single-strain enrichment of Ca. Electronema aureum. We recovered multiple cable bacteria MAGs, including two circular and one single-contig. Phylogenomic analysis, also confirmed by 16S rRNA gene-based phylogeny, classified one circular MAG and the single-contig MAG as novel species of cable bacteria, which we propose to name Ca. Electronema halotolerans and Ca. Electrothrix laxa, respectively. The Ca. Electronema halotolerans, despite belonging to the previously recognized freshwater genus of cable bacteria, was retrieved from brackish-water sediment. Metabolic predictions showed several adaptations to a high salinity environment, similar to the “saltwater” Ca. Electrothrix species, indicating how Ca. Electronema halotolerans may be the evolutionary link between marine and freshwater cable bacteria lineages.
Cortical-blood vessel assembloids exhibit Alzheimer’s disease phenotypes by activating glia after SARS-CoV-2 infection
Authors: Kong Dasom , Park Ki Hoon , Kim Da-Hyun , Kim Nam Gyo , Lee Seung-Eun , Shin Nari , Kook Myung Geun , Kim Young Bong , Kang Kyung-Sun 
Published: January 2023

AbstractA correlation between COVID-19 and Alzheimer’s disease (AD) has been proposed recently. Although the number of case reports on neuroinflammation in COVID-19 patients has increased, studies of SARS-CoV-2 neurotrophic pathology using brain organoids have restricted recapitulation of those phenotypes due to insufficiency of immune cells and absence of vasculature. Cerebral pericytes and endothelial cells, the major components of blood-brain barrier, express viral entry receptors for SARS-CoV-2 and response to systemic inflammation including direct cell death. To overcome the limitations, we developed cortical-blood vessel assembloids by fusing cortical organoid with blood vessel organoid to provide vasculature to brain organoids a nd obtained the characteristics of increased expression of microglia and astrocytes in brain organoids. Furthermore, we observed AD pathologies, including β-amyloid plaques, which were affected by the inflammatory response from SARS-CoV-2 infection. These findings provide an advanced platform to investigate human neurotrophic diseases, including COVID-19, and suggest that neuroinflammation caused by viral infection facilitates AD pathology.
Gut microbiota and microbiota-derived metabolites promotes endometriosis
Authors: Chadchan Sangappa B. , Naik Sumanta K. , Popli Pooja , Talwar Chandni , Putluri Satwikreddy , Ambati Chandrasekhar R. , Lint Michael A. , Kau Andrew L. , Stallings Christina L. , Kommagani Ramakrishna 
Published: January 2023

AbstractEndometriosis is a pathological condition of the female reproductive tract characterized by the existence of endometrium-like tissue at ectopic sites, affecting 10% of women between the age 15 and 49 in the USA. However, currently there is no reliable non-invasive method to detect the presence of endometriosis without surgery and many women find hormonal therapy and surgery as ineffective in avoiding the recurrences. There is a lack of knowledge on the etiology and the factors that contribute to the development of endometriosis. A growing body of recent evidence suggests an association between gut microbiota and endometriosis pathophysiology. However, the direct impact of microbiota and microbiota-derived metabolites on the endometriosis disease progression is largely unknown. To understand the causal role of gut microbiota and endometriosis, we have implemented a novel model using antibiotic-induced microbiota-depleted (MD) mice to investigate the endometriosis disease progression. Interestingly, we found that MD mice showed reduced endometriotic lesion growth and, the transplantation of gut microbiota by oral gavage of feces from mice with endometriosis rescued the endometriotic lesion growth. Additionally, using germ-free donor mice, we indicated that the uterine microbiota is dispensable for endometriotic lesion growth in mice. Furthermore, we showed that gut microbiota modulates immune cell populations in the peritoneum of lesions-bearing mice. Finally, we found a novel signature of microbiota-derived metabolites that were significantly altered in feces of mice with endometriosis. Finally, we found one the altered metabolite, quinic acid promoted the survival of endometriotic epithelial cells in vitro and lesion growth in vivo, suggesting the disease-promoting potential of microbiota-derived metabolites. In summary, these data suggest that gut microbiota and microbiota-derived metabolome contribute to lesion growth in mice, possibly through immune cell adaptations. Of translational significance, these findings will aid in designing non-invasive diagnostics using stool metabolites for endometriosis.
Enhancing the coherence of superconducting quantum bits with electric fields
Authors: Lisenfeld Jürgen , Bilmes Alexander , Ustinov Alexey V. 
Published: January 2023

AbstractIn the endeavor to make quantum computers a reality, integrated superconducting circuits have become a promising architecture. A major challenge of this approach is decoherence originating from spurious atomic tunneling defects at the interfaces of qubit electrodes, which may resonantly absorb energy from the qubit’s oscillating electric field and reduce the qubit’s energy relaxation time T1. Here, we show that qubit coherence can be improved by tuning dominating defects away from the qubit resonance using an applied DC-electric field. We demonstrate a method that optimizes the applied field bias and enhances the average qubit T1 time by 23%. We also discuss how local gate electrodes can be implemented in superconducting quantum processors to enable simultaneous in situ coherence optimization of individual qubits.
City-scale holographic traffic flow data based on vehicular trajectory resampling
Authors: Wang Yimin , Chen Yixian , Li Guilong , Lu Yuhuan , He Zhaocheng , Yu Zhi , Sun Weiwei 
Published: January 2023

AbstractDespite abundant accessible traffic data, researches on traffic flow estimation and optimization still face the dilemma of detailedness and integrity in the measurement. A dataset of city-scale vehicular continuous trajectories featuring the finest resolution and integrity, as known as the holographic traffic data, would be a breakthrough, for it could reproduce every detail of the traffic flow evolution and reveal the personal mobility pattern within the city. Due to the high coverage of Automatic Vehicle Identification (AVI) devices in Xuancheng city, we constructed one-month continuous trajectories of daily 80,000 vehicles in the city with accurate intersection passing time and no travel path estimation bias. With such holographic traffic data, it is possible to reproduce every detail of the traffic flow evolution. We presented a set of traffic flow data based on the holographic trajectories resampling, covering the whole city, including stationary average speed and flow data of 5-minute intervals and dynamic floating car data (FCD).
China’s process-related greenhouse gas emission dataset 1990–2020
Authors: Yu Xiang , Tan Chang 
Published: January 2023

AbstractChina’s industrial process-related Greenhouse Gas (GHG) emissions are growing rapidly and are already equivalent to 13–19% of energy-related emissions in the past three decades. Previous studies mainly focused on emissions from fossil fuel combustion, however, there are a broad range of misconceptions regarding the trend and source of process-related emissions. To effectively implement emission reduction policies, it is necessary to compile an accurate accounting of process-related GHG emissions. However, the incompleteness in scope, unsuitable emission factor, and delay in updates in the current emission inventory have led to inaccurate emission estimates and inefficient mitigation actions. Following the methodology provided by Intergovernmental Panel on Climate Change (IPCC), we constructed a time series inventory of process-related GHG emissions for 15 industrial products from 1990–2020 in China. This emission inventory covers more than 90% of China’s process-related GHG emissions. In our study, emission factors were adjusted to refer to the industrial production process, technology, and raw material structure in China, which has led to increased accuracy of emission accounting. The dataset can help identify the sources of process-related GHG emissions in China and provide a data base for further policy implications.
Buffalo milk and rumen fluid metabolome are significantly affected by green feed
Authors: Neglia G. , Cotticelli A. , Vassetti A. , Matera R. , Staropoli A. , Vinale F. , Salzano A. , Campanile G. 
Published: January 2023

AbstractThe use of green feed for livestock breeding is an important strategy to encounter both the increasing demand for animal derived products and the perceptions of the consumers regarding animal welfare and sustainability. The aim of this study was to compare different feeding strategies in lactating water buffaloes by using a metabolomic approach. The study was carried out on 32 milking buffaloes that were randomly divided into two groups for a total period of 90 days (3 sampling times). DD Group (dry diet) received a standard total mixed ratio (TMR) characterized by dry forages and concentrates; ZG Group (zero grazing) fed an isoenergetic and isoproteic diet obtained using 30% of sorghum as green forage. Samples of milk and rumen fluid were analyzed by liquid chromatography—mass spectrometry (LC–MS) techniques. Data analyses revealed the presence of several differentially accumulated metabolites and among these, ten compounds were putatively identified in milk samples (i.e. l-carnitine, acetylcarnitine, propionylcarnitine, butyrylcarnitine, 2-methylbutyroylcarnitine, 2-hexenoylcarnitine, hexanoylcarnitine, glycerophosphocholine, δ-valerobetaine and γ-butyrobetaine) and four in rumen fluid (3-(2-hydroxyphenyl) propanoate, Indole-3-acrylic acid, oleamide (cis-9,10-octadecenoamide) and 20-carboxy-leukotriene B4). The modulation of these molecules in buffalo milk is significantly related to the green/dry based feeding and some the natural compound detected could be considered as health-promoting nutrients.
Administration of anti-inflammatory M2 macrophages suppresses progression of angiotensin II-induced aortic aneurysm in mice
Authors: Ashida Shinichi , Yamawaki-Ogata Aika , Tokoro Masayoshi , Mutsuga Masato , Usui Akihiko , Narita Yuji 
Published: January 2023

AbstractAortic aneurysm (AA) is a vascular disorder characterized pathologically by inflammatory cell invasion and extracellular matrix (ECM) degradation. It is known that regulation of the balance between pro-inflammatory M1 macrophages (M1Ms) and anti-inflammatory M2 macrophages (M2Ms) plays a pivotal role in AA stabilization. We investigated the effects of M2M administration in an apolipoprotein E-deficient (apoE−/−) mouse model in which AA was induced by angiotensin II (ATII) infusion. Mice received intraperitoneal administration of 1 million M2Ms 4 weeks after ATII infusion. Compared with a control group that was administered saline, the M2M group exhibited reduced AA expansion; decreased expression levels of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), and monocyte chemoattractant protein-1 (MCP-1); and a lower M1M/M2M ratio. Moreover, the M2M group exhibited upregulation of anti-inflammatory factors, including IL-4 and IL-10. PKH26-labeled M2Ms accounted for 6.5% of cells in the aneurysmal site and co-expressed CD206. Taken together, intraperitoneal administration of M2Ms inhibited AA expansion by reducing the inflammatory reaction via regulating the M1M/M2M ratio. This study shows that M2M administration might be useful for the treatment of AA.
Vascular malperfusion and abruption are prevalent in placentas from pregnancies with congenital heart disease and not associated with cardiovascular risk
Authors: Altendahl Marie , Mok Thalia , Adimkpayah Ekene , Goldstein Jeffrey , Lin Jeannette , Afshar Yalda 
Published: January 2023

AbstractCongenital heart disease (CHD) in pregnancy is associated with an increased risk of adverse maternal, obstetric, and neonatal outcomes, plausibly through mechanisms involving abnormal placental development and function. This retrospective study aims to elucidate how maternal CHD influences placental health. Demographic and clinical information were collected via electronic medical record review, and placentas underwent histopathological evaluation. Fifty-three singleton pregnancies were included: 35 participants (66%) were classified as lower cardiovascular risk (modified World Health Organization Classification (mWHO) I, II, II-III), and 18 (34%) were classified as higher cardiovascular risk (mWHO III, IV). 12 participants (23%) had a fetus with small for gestational age (SGA). Maternal vascular malperfusion (53%) and placental abruption (11.6%) were common in this cohort, with prevalence above baseline risk. Participants at higher cardiovascular risk had higher rates of SGA (p = 0.04), subchorionic hematomas (p = 0.01) and birth weight:placental weight < 10th percentile (p = 0.04), but did not differ in rates of maternal vascular malperfusion (p = 0.15) compared to those at lower cardiovascular risk. In pregnancies with maternal CHD, SGA and histologic evidence of maternal vascular malperfusion and placental abruption were common, though patients at higher cardiovascular risk did not show evidence of worsened placental health compared to those at lower risk.