bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carry‐over effects of nestling physical condition predict first‐year survival of a critically endangered migratory parrot
Authors: Bussolini L. T. , Crates R. , Herrod A. , Magrath M. J. L. , Troy S. , Stojanovic D. 
Published: May 2023

AbstractConservation breeding programs are an increasingly important tool to help supplement declining wild populations, but captive‐bred animals generally do not survive well post‐release. Early life in captivity has the potential to influence growth and development, with impacts carrying over to affect survival. Understanding carry‐over effects of captivity and consequences on survival is critically important for conservation efforts globally but remains poorly understood. We examined the relationship between early‐life environment, physical condition, and juvenile survival of wild and captive‐bred critically endangered orange‐bellied parrots (Neophema chrysogaster). Using nestling growth models, we calculated a body condition index for 1,039 wild and captive‐bred orange‐bellied parrots hatched over six breeding seasons. Nestling body condition varied with year, provenance, and brood position. Wild nestlings had consistently higher body condition than captive‐bred nestlings, and first‐hatched nestlings were typically heavier than later hatched siblings. We then investigated first‐year survival for 298 wild‐born and captive‐bred released parrots in the wild. Overall, first‐year survival was 27.5%, and individual body condition was more influential than provenance in predicting survival. Our findings could be used to aid the selection of individuals for release that have the best prospects of surviving in the wild. This study addresses important questions about the post‐release fitness of captive‐bred animals, and our metric of assessing physical condition provides a straightforward tool for other conservation breeding programs to adapt management techniques to improve survival outcomes.
Low dosage of prednisone acetate combined with doxycycline in the treatment of chronic endometritis in patients with repeated implantation failure
Authors: Zou Yujie , Ming Lei , Ding Jinli , Xiao Zhuoni , Li Saijiao , Yang Jing , Bao Anyu , Zhang Yan 
Published: May 2023

AbstractObjectiveTo retrospectively investigate whether the oral administration of prednisone acetate with doxycycline increases the cure rate of chronic endometritis (CE) and improves in vitro fertilization (IVF) outcomes in patients with repeated implantation failure (RIF) with CE.MethodsIn total, 352 patients with RIF were investigated, 128 of whom were diagnosed with CE by hysteroscopy and endometrial immunohistochemical analysis. The patients with CE were divided into CD138‐positive high‐power field (HPF) counts of 1–2 and ≥3. Forty‐five patients were orally administered prednisone acetate tablet 5 mg daily and doxycycline 100 mg twice daily for 14 consecutive days (group A), and 55 patients were administered doxycycline 100 mg orally twice daily for 14 days (group B) and underwent repeated endometrial sampling and histological assessment. Twenty‐eight patients (group C) did not receive any treatment. The cure rate of CE and final reproductive outcomes of the frozen‐thawed embryo transfer cycle were compared.ResultsThe total cure rate, cure rate of patients with CE(CD138+ HPF counts: 1–2), and cure rate of patients with CE(CD138+ HPF counts: ≥3) showed no significant difference between groups A and B. Logistics regression analysis indicated that the implantation rate, human chorionic gonadotropin (hCG)‐positive rate, clinical pregnancy rate, clinical pregnancy rate with fetal heartbeat on day 30 (D30), and ongoing pregnancy rate was significantly higher in group A than in group C. For CE‐cured patients after the treatment, the implantation rate, hCG‐positive rate, clinical pregnancy rate, clinical pregnancy rate with fetal heartbeat on D30, and ongoing pregnancy rate were significantly higher in group A than in group B.ConclusionCE is closely related to RIF occurrence, and the combined oral administration of prednisone acetate and doxycycline can be a treatment option for patients with RIF with CE and improves reproductive outcomes, although it does not improve the CE cure rate compared with doxycycline treatment alone.
Percutaneous decannulation of venoarterial extracorporeal membrane oxygenation using the Manta vascular closure device: A systematic review and meta‐analysis
Authors: Ng Jun Jie , Lee Stefanie H. T. , Lim Joseph K. W. , Chan Karen K. W. , Lim Mark D. S. , Ahmed Mohamed A. I. , Loh Stanley E. K. , Choong Andrew M. T. L. 
Published: May 2023

AbstractObjectivesTo perform a systematic review and meta‐analysis of the techniques and outcomes associated with percutaneous decannulation of venoarterial extracorporeal membrane oxygenation (VA–ECMO) using the Manta vascular closure device.BackgroundPeripheral VA–ECMO can be used to treat critically ill patients with conditions such as refractory cardiogenic shock. After percutaneous implantation of VA–ECMO, VA–ECMO can also be decannulated completely percutaneously by using a vascular closure device. The Manta vascular closure device is a dedicated device used in the closure of large‐bore arteriotomies by sandwiching the arteriotomy with an intra‐arterial toggle and an extraluminal collagen plug.MethodsWe performed a thorough literature search using various electronic databases. We included studies that reported outcomes after peripheral femorofemoral VA–ECMO decannulation with the Manta vascular closure device. We performed a meta‐analysis of proportions on outcome measures, including technical success, bleeding complications, vascular complications, wound complications, major amputation, and procedural‐related deaths.ResultsWe included seven studies with a total of 116 patients. The overall technical success of percutaneous decannulation of VA–ECMO with the Manta vascular closure device was 93.7%. The overall incidence of bleeding, vascular and wound complications was 1.7%, 13.8%, and 3.4%, respectively. No patient required lower limb amputation or died due to VA–ECMO decannulation.ConclusionPercutaneous decannulation with the Manta vascular closure device is an effective and safe procedure that should be considered in suitable patients on VA–ECMO.
Associations of breastfeeding duration and cognitive development from childhood to middle adolescence
Authors: Lovcevic Irena 
Published: May 2023

AbstractAimTo assess the dose–response association between the duration of any breastfeeding and cognitive skills in children from 5 to 15 years of age.MethodsThe data from the longitudinal cohort study Growing up in Australia: The Longitudinal Study of Australian Children (children born in 1999–2000 and 2003–2004) were accessed. Language skills were assessed via Peabody Picture Vocabulary Test at 5, 7 and 9 years of age (N = 8643), and non‐verbal intelligence was assessed via Matrix Reasoning subtest from Wechsler Intelligence Scale at 7, 9 and 11 years of age (N = 8560) and executive functions were examined via Cogstate Cognitive Testing battery in 15 years old (N = 6213). Breastfeeding was assessed via maternal questionnaires, partly prospective.ResultsA longer duration of breastfeeding was significantly associated with greater language skills from 5 to 9 (0.05 [95% CI, 0.03–0.08], p < 0.0001) and greater non‐verbal intelligence from 7 to 11 years of age (0.02 [95% CI, 0.01–0.04], p < 0.001). No significant relation was found between the breastfeeding duration and executive functions in 15 years old.ConclusionThese results support a dose–response relationship between breastfeeding duration and language skills and non‐verbal intelligence during childhood and early adolescence.
Clinical characteristics and risk factors for tigecycline‐induced pancreatitis in a tertiary hospital: A retrospective study
Authors: Tan Qinghai , Zhang Yu , Liu Mei , Tian De'an , Wu Xiaohui , Zhou Lei , Fan Wenjuan 
Published: May 2023

AimsTo analyse the clinical characteristics and risk factors for tigecycline‐induced pancreatitis (TIP) and evaluate the safety and efficiency of tigecycline use in non‐TIP.MethodsA retrospective case‐control study was conducted on adult and juvenile patients administered tigecycline for >3 days. The adults were classified as TIP, non‐TIP (pancreatitis with other causes) and non‐pancreatitis. Univariate analyses were performed to compare TIP and non‐pancreatitis, and multivariate analysis was used to identify risk factors for TIP. The clinical characteristics of TIP, and the safety and efficiency of tigecycline use in non‐TIP were evaluated.ResultsA total of 3910 patients (3823 adults and 87 juveniles) were enrolled. The adult patients comprised 21 TIP, 82 non‐TIP and 3720 non‐pancreatitis. The TIP prevalence was 0.56% in adults and 1.15% in juveniles. The mean time from tigecycline use to symptom onset was 7.2 days, and all cases were mild pancreatitis. The mean time from tigecycline withdrawal to symptom relief was 3.6 days. The multivariate analysis identified comorbid renal insufficiency as an independent risk factor for TIP (odds ratio = 3.032). Among the 82 non‐TIP patients, 81.7% had severe pancreatitis and 47.6% had necrotizing pancreatitis. The modified computed tomography severity score after tigecycline use was similar to that before tigecycline use, but the pancreatic enzymes and infection indices were significantly decreased.ConclusionsThe prevalence of TIP was low. Comorbid renal insufficiency was as an independent risk factor for TIP. Tigecycline is safe and efficient for treatment of pancreatitis, especially necrotizing pancreatitis, with intra‐abdominal infection.
The application of artificial intelligence to accelerate G protein‐coupled receptor drug discovery
Authors: Nguyen Anh T. N. , Nguyen Diep T. N. , Koh Huan Yee , Toskov Jason , MacLean William , Xu Andrew , Zhang Daokun , Webb Geoffrey I. , May Lauren T. , Halls Michelle L. 
Published: May 2023

The application of artificial intelligence (AI) approaches to drug discovery for G protein‐coupled receptors (GPCRs) is a rapidly expanding area. Artificial intelligence can be used at multiple stages during the drug discovery process, from aiding our understanding of the fundamental actions of GPCRs to the discovery of new ligand‐GPCR interactions or the prediction of clinical responses. Here, we provide an overview of the concepts behind artificial intelligence, including the subfields of machine learning and deep learning. We summarise the published applications of artificial intelligence to different stages of the GPCR drug discovery process. Finally, we reflect on the benefits and limitations of artificial intelligence and share our vision for the exciting potential for further development of applications to aid GPCR drug discovery. In addition to making the drug discovery process “faster, smarter and cheaper,” we anticipate that the application of artificial intelligence will create exciting new opportunities for GPCR drug discovery.LINKED ARTICLESThis article is part of a themed issue Therapeutic Targeting of G Protein‐Coupled Receptors: hot topics from the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists 2021 Virtual Annual Scientific Meeting. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.14/issuetoc
Design, synthesis, and evaluation of antitumor activity of novel C‐6 sulfhydryl‐substituted and 20‐substituted derivatives of celastrol
Authors: Su Di , Wei Rong‐yuan , Yan Zhi‐ming , Zhong Guo‐hui , Qin Xiang‐qing , Huang Shu‐tong , Long Juan‐yue , Zhang Feng‐ling , He Ping , Chen Zhong‐ji , Yan Ya‐qian , Jiang Neng , Tang Wei‐zhong 
Published: May 2023

AbstractCelastrol has been identified as a potential candidate for anticancer drug development. In this study, 28 novel celastrol derivatives with C‐6 sulfhydryl substitution and 20‐substitution were designed and synthesized, and their antiproliferative activity against human cancer cells and non‐malignant human cells was evaluated, with cisplatin and celastrol being used as controls. The results showed that most of the derivatives had enhanced in vitro anticancer activity compared to the parent compound celastrol. Specifically, derivative 2f demonstrated the most potent inhibitory potential and selectivity against HOS with an IC50 value of 0.82 μM. Our study provides new insights into the structure–activity relationship of celastrol and suggests that compound 2f may be a promising drug candidate for the treatment of osteosarcoma.
The GLCCI1 rs37973 variant and the efficacy of inhaled corticosteroids in the treatment of asthma: A meta‐analysis
Authors: Feng Wen‐Ling , Pu Wen , Li Jing , Yuan Yuan , Yan Ming‐Zhi , Yuan Shuang‐Li , Li Yu‐Kun , Wu Jie‐Ru , Xu Shao‐Quan , Zhao Jun 
Published: May 2023

AbstractObjectiveThis study investigated the relationship between the glucocorticoid‐induced transcript 1 (GLCCI1) gene variant and the degree of improvement in lung function with inhaled corticosteroids (ICS).MethodsWe searched the PubMed, Embase, Cochrane Library, CBM, CNKI and Wanfang databases to obtain studies on the GLCCI1 rs37973 variant and the efficacy of ICS in asthma.ResultsThe overall meta‐analysis showed that patients with the GG phenotype (mutant homozygotes) exhibited significantly smaller forced expiratory volume in 1 sec (FEV1) change than patients with the AG phenotype (mutant heterozygous) (MD = −0.08, 95% CI [−0.12, −0.03], P = 0.001). Compared with the AA phenotype (wild homozygotes), the GG phenotype (MD = −4.23, 95% CI [−6.09, −2.38], P < 0.00001) and AG phenotype (MD = −1.92, 95% CI [−2.35, −1.49], P < 0.00001) had significantly smaller FEV1%pred changes. The FEV1 change subgroup analysis showed that the GG phenotype group was smaller than the AA phenotype group at 8 (MD = −0.53, 95% CI [−0.91, −0.14], P = 0.007), 12 (MD = −0.16, 95% CI [−0.30, −0.02], P = 0.02) and 24 (MD = −0.09, 95% CI [−0.17, −0.01], P = 0.02) weeks of treatment; the GG phenotype group was smaller than the AG phenotype group at 12 weeks (MD = −0.08, 95% CI [−0.15, −0.01], P = 0.02).ConclusionThis meta‐analysis suggests that the GLCCI1 rs37973 variant affects the efficacy of ICS and that the presence of the G allele attenuates the improvement in lung function with ICS.
Use of hospital care among Dutch diabetes patients
Authors: de Vries Silvia A. G. , Bak Jessica C. G. , Stangenberger Vincent A. , Wouters Michel W. J. M. , Nieuwdorp Max , Sas Theo C. J. , Verheugt Carianne L. 
Published: May 2023

AbstractAimTo provide insight into healthcare resource utilization and hospital expenditure of patients treated for diabetes in Dutch hospitals.Materials and methodsWe conducted an observational cohort study of 193 840 patients aged ≥18 years and treated for diabetes mellitus in 65 Dutch hospitals in 2019 to 2020, using real‐world reimbursement data. Consultations, hospitalizations, technology use, total hospital and diabetes care costs (encompassing all care for diabetes itself) were assessed during 1‐year follow‐up. In addition, expenditure was compared with that in the general Dutch population.ResultsTotal hospital costs for all patients with diabetes were €1 352 690 257 (1.35 billion) per year, and 15.9% (€214 963 703) was associated with treatment of diabetes. Mean yearly costs per patient were €6978, with diabetes care costs of €1109. Mean hospital costs of patients exceeded that of the Dutch population three‐ to sixfold. Total hospital costs increased with age, whereas diabetes expenditure decreased with age (18‐40 years, €1575; >70 years, €932). Of all patients with diabetes, 51.3% (n = 99 457) received care related to cardiovascular complications. Micro‐ and macrovascular complications, or a combination, increased hospital costs (1.4‐5.3 times higher).ConclusionsThe hospital resource use of Dutch diabetes patients is high, with a large burden of cardiovascular complications. Resource use is rooted mainly in hospital care of diabetes‐related complications, not in the treatment of diabetes. Early treatment and prevention of complications remain imperative to taper future healthcare expenditure on patients with diabetes.
Bimanual coupling is associated with left frontocentral network activity in a task‐specific way
Authors: Rudisch Julian , Fröhlich Stephanie , Pixa Nils H. , Kutz Dieter F. , Voelcker‐Rehage Claudia 
Published: May 2023

AbstractWhen performing bimanual tasks, hands are typically not controlled individually but rather as a coupled system to achieve high spatiotemporal coordination. On a brain level, intrahemispheric and interhemispheric networks that control the left and right hand are necessary to exchange information between hemispheres and to couple movements. Behaviourally, coupling is, however, highly task‐specific requiring, for example, to maintain a specific relative phase in cyclic tasks (e.g., inphase or antiphase) or to perform a role differentiated task where one hand is modulating and the other hands is stabilizing and needs to be kept as still as possible (e.g., holding a notepad and writing on it). In this study, we used electroencephalography to investigate functional brain network characteristics (task‐related activation and connectivity) in bimanual force‐control tasks with different coordination modes: inphase, antiphase and role‐differentiated with the left‐ or right‐hand stabilizing and the other hand manipulating. We aimed to examine (1) how network characteristics differ with respect to the coordination mode and (2) how they are related to the performance. Results revealed task‐related differences in the overall activation and connectivity with role‐differentiated tasks leading to higher desynchronization as compared to inphase and antiphase tasks. In addition, we showed that the strength of bimanual coupling is modulated task specifically through left‐hemispheric networks including C3, FC3 and F3 electrodes. Results highlight the importance of the left frontocentral regions for bimanual coordination.
NT‐proBNP and changes in cognition and global brain structure: The Rotterdam Study
Authors: Xiao Tian , van der Velpen Isabelle F. , Niessen Wiro J. , Tilly Martijn J. , Kavousi Maryam , Ikram M. Arfan , Ikram M. Kamran , Vernooij Meike W. 
Published: May 2023

AbstractObjectiveTo investigate the association between N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) and changes in cognition and global brain structure.MethodsIn the Rotterdam Study, baseline NT‐proBNP was assessed at baseline from 1997 to 2008. Between 1997 and 2016, participants without dementia or stroke at baseline (n = 9566) had repeated cognitive tests (every 3–6 years) for global cognitive function, executive cognitive function, fine manual dexterity, and memory. Magnetic resonance imaging of the brain was performed repeatedly at re‐examination visits between 2005 and 2015 for 2607 participants to obtain brain volumes, focal brain lesions, and white matter microstructural integrity as measures of brain structure.ResultsAmong 9566 participants (mean age 65.1 ± 9.8 years), 5444 (56.9%) were women, and repeated measures of cognition were performed during a median follow‐up time of 5.5 (range 1.1–17.9) years, of whom 2607 participants completed at least one brain imaging scan. Higher levels of NT‐proBNP were associated with a faster decline of scores in the global cognitive function (p value = 0.003) and the Word‐Fluency test (p value = 0.003) but were not related to a steeper deterioration in brain volumes, global fractional anisotropy, and mean diffusivity, as indicators of white matter microstructural integrity, or focal brain lesions.ConclusionsHigher baseline NT‐proBNP levels were associated with a faster decline in cognition; however, no association with global brain structure was found.
Treatment implications of augmented renal clearance in a critically ill COVID‐19 patient: A case report
Authors: Deenen Susan , Fransen Laura F. C. , Jaspers Tessa C. C. , Workum Jessica D. 
Published: May 2023

AbstractAugmented renal clearance (ARC) is a pathophysiological phenomenon that can occur in critically ill patients, leading to enhanced renal function. It is defined as a creatinine clearance of >130 mL/min/1.73 m2. ARC can lead to subtherapeutic levels of renally cleared drugs and subsequent treatment failure. In COVID‐19, it has only been described in the literature in a few cases. We present the case of a 38‐year‐old critically ill patient with COVID‐19 who developed ARC with an initial clearance of 226 mL/min/1.73 m2, persisting for 30 days. He required high doses of sedatives and neuromuscular blocking agents, as well as increased doses of vancomycin and dalteparin, to reach adequate serum levels. This case emphasizes the importance for clinicians to consider ARC in the dosing of all renally cleared drugs, including antibiotics, low molecular weight heparins, and sedatives, to prevent subtherapeutic drug levels and treatment failure.
Crack tip fields effects on crack propagation through the heat affected zone in an overmatched welded joint
Authors: Adziev Gorgi , Sedmak Aleksandar , Sedmak Simon , Adziev Todor , Radakovic Zoran 
Published: May 2023

AbstractThe mismatching constraint effect on crack propagation through the heat‐affected zone (HAZ) in a welded joint is presented in this paper. It is shown that due to this effect, the fracture behavior of an overmatched welded joint depends on the mechanical properties and the size of the region of the crack tip location, as well as on the properties and the size of surrounding regions. The finite element analysis of high‐strength low‐alloyed (HSLA) steel welded joints with crack tips in the heat‐affected zone is performed based on previous experimental work. Two locations of the crack tip are analyzed: fine‐grained HAZ (FGHAZ) and coarse‐grained HAZ (CGHAZ). In both cases, after the initial propagation of the crack in FGHAZ or CGHAZ, its propagation is directed toward more ductile base metal, thus increasing the fracture resistance of a welded joint. Some new observations about the reasons for such behavior due to crack tip strain fields are presented as well.
Effect of current density and polytetrafluoroethylene on the properties of micro‐arc oxide coating of pure aluminum
Authors: Chen Jian , Li Wangning , Xu Jinxin , Bai Zhongdong , Wang Changkai , Wang Saisai 
Published: May 2023

AbstractMicro‐arc oxidation (MAO) is a surface treatment technology that enhances the surface properties of valves by creating a ceramic oxide layer on the metal surface. The goal of this study is to investigate the influence of current density on the properties of aluminum coatings during preparation and to improve the tribological properties of MAO/PTFE self‐lubricating films on the coating surface. The characterization of the coating was performed using X‐ray photoelectron spectroscopy, X‐ray diffraction, Raman spectra, and energy dispersive spectroscopy. The roughness, hardness, and elastic modulus of the coatings were tested using atomic force microscopy and nanoindentation. Tribological experiments were conducted to evaluate the tribological properties of the coatings. The experimental results show that the friction coefficient (COF), roughness, hardness, and elastic modulus of the MAO coating increase with the increase of current density. Additionally, the friction coefficient of the MAO composite coating significantly decreases after the addition of polytetrafluoroethylene (PTFE), improving the service life and application range of the metal coating. These findings are expected to promote the development of valve metal in various application fields.