bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential contribution of floral thermogenesis to cold adaptation, distribution pattern, and population structure of thermogenic and non/slightly thermogenic Symplocarpus species
Authors: Sato Mitsuhiko P. , Matsuo Ayumi , Otsuka Koichi , Takano Kohei Takenaka , Maki Masayuki , Okano Kunihiro , Suyama Yoshihisa , Ito‐Inaba Yasuko 
Published: July 2023

AbstractThe genus Symplocarpus in basal Araceae includes both thermogenic and non/slightly thermogenic species that prefer cold environments. If floral thermogenesis of Symplocarpus contributes to cold adaptation, it would be expected that thermogenic species have a larger habitat than non/slightly thermogenic species during an ice age, leading to increased genetic diversity in the current population. To address this question, potential distribution in past environment predicted by ecological niche modeling (ENM), genetic diversity, and population structure of chloroplast and genome‐wide single nucleotide polymorphisms were compared between thermogenic Symplocarpus renifolius and non/slightly thermogenic Symplocarpus nipponicus. ENM revealed that the distribution of S. nipponicus decreased, whereas that of S. renifolius expanded in the Last Glacial Maximum. Phylogeographic analyses have shown that the population structures of the two species were genetically segmented and that the genetic diversity of S. renifolius was higher than that of S. nipponicus. The phylogenetic relationship between chloroplast and nuclear DNA is topologically different in the two species, which may be due to the asymmetric gene flow ubiquitously observed in plants. The results of this study imply that floral thermogenesis of Symplocarpus contributes to expanding the distribution during an ice age, resulting in increased genetic diversity due to cold adaptation.
Temporal dynamics in diversity and composition of the air mycobiome and dominant allergenic fungi in the subway environment
Authors: Harnpicharnchai Piyanun , Siriarchawatana Paopit , Pumkaeo Panyapon , Likhitrattanapisal Somsak , Mayteeworakoon Sermsiri , Zhou Xin , Liang Junmin , Gafforov Yusufjon , Eurwilaichitr Lily , Cai Lei , Ingsriswang Supawadee 
Published: July 2023

AbstractAnalyzing and monitoring air microbiomes in the subway environment has a great impact on public health, especially in urban cities. In this study, temporal distribution profile of air mycobiome at Bangkok's Sukhumvit subway station (MRT‐SKV) was explored over 12 samplings during December 2021–November 2022 by the environmental DNA‐metabarcoding approach. The top 5 most abundant fungal genera identified were Yarrowia, Cladosporium, Hortaea, Cutaneotrichosporon, and Leptobacillum. Among the 496 genera found, 24 genera could be considered “core mycobiome” of the MRT‐SKV air, as they were consistently found in ≥85% of the samples. Many members of the core mycobiome constituted human commensal genera, but several of them can elicit allergic reactions in humans and thus pose a potential health risk. Cladosporium was the most abundant allergenic fungi found in the MRT‐SKV, which is in contrast to Malassezia, Ustilago, or Aspergillus being the most abundant allergenic fungi in subway environments in other countries. The fungal compositions in the subway environment differed temporally, and the abundances of allergenic fungi were the highest in samples obtained during the first and seventh samplings (done in December 2021–June 2022). These compositional variations were most likely influenced by air quality variables, including particulate matter (PM), temperature, and relative humidity, which showed seasonal variations. Finally, certain fungal genera were shown to co‐occur together in co‐occurrence network. Many of the allergenic fungal genera formed networks more prominently in rush hour than in other traffic hours. The co‐occurrence network suggested associations among certain fungal genera, such as the association between Malassezia–Nigrospora, Alternaria–Aspergillus, and Aspergillus–Cutaneotrichosporon in the MRT‐SKV bioaerosols. The implied associations between these fungi are worth further investigation since they may point toward their impact on human health (as they are opportunistic fungi found in human). Our results thus facilitate understanding the ecological and health impacts of fungal components of the subway air environment.
Inter‐attitude centrality does not appear to reduce persuasion for political attitudes
Authors: Brandt Mark J. , Vallabha Shree 
Published: July 2023

AbstractAre attitudes more resistant to change when they are more central to a belief system? Theories of inter‐attitude structure and belief system dynamics both suggest that the answer is yes. We demonstrate how to combine belief system network methods with pretest‐posttest experiments to empirically test this idea. We aimed to persuade US conservatives (Experiment 1 N = 890) and US liberals (Experiment 2 N = 1305, Experiment 3 N = 1293) using moral reframing persuasive strategies. Although we find that moral reframing was persuasive (9 of 12 attempts), there was no evidence that central attitudes were more difficult to change than peripheral attitudes. This was the case across all experiments, target attitudes and methods for assessing belief system structure. The results suggest that moral reframing persuades people, but that theories of inter‐attitude structure and belief system dynamics both do not make accurate predictions in this situation.
Electrochemical biosensors for rapid diagnosis of bacterial infections: Design, targets and applications in clinical setting
Authors: Koçak Engin , Ozkul Ceren , Bozal‐Palabiyik Burcin , Süslü İncilay , Uslu Bengi 
Published: July 2023

AbstractIn clinical settings, quickly identifying and detecting bacterial infections is crucial. Current methods for identifying and measuring these diseases take a long time and are frequently expensive. Hence, biosensor systems may be a viable alternative to conventional systems. Electrochemical systems based on different materials have great potential for developing rapid methods to detect pathogens in many areas. They are cheaper and reliable, have a relatively fast response time, and provide better stability and sensitivity. This review article assesses the recent advancements and potential of electrochemical biosensors for monitoring/detecting different pathogens in clinical samples. After mentioning standard techniques for detecting various microorganisms, the article introduced the biosensor‘s fundamental conceptualization and its varieties, functioning principles, and advantages. Then it discussed the applicability of various electrochemical systems employed in clinical analysis. It reviewed DNA, RNA and protein‐based systems as methods of direct pathogen analysis and underlined metabolite‐based indirect systems, the new trend in microbiology and life sciences, with their potential for detecting infectious diseases.
Effect of MAPK activation via mutations in NRAS, KRAS and BRAF on clinical outcome in newly diagnosed multiple myeloma
Authors: Perroud Camille , Thurian Dario , Andres Martin , Künzi Arnaud , Wiedemann Gertrud , Zeerleder Sacha , Bacher Ulrike , Pabst Thomas , Banz Yara , Porret Naomi , Rebmann Ekaterina 
Published: July 2023

AbstractUntil now, next generation sequencing (NGS) data has not been incorporated into any prognostic stratification of multiple myeloma (MM) and no therapeutic considerations are based upon it. In this work, we correlated NGS data with (1) therapy response and survival parameters in newly diagnosed multiple myeloma, treated by VRd * and (2) MM disease stage: newly diagnosed multiple myeloma (ndMM) versus relapsed and/or refractory (relapsed/refractory multiple myeloma). We analyzed 126 patients, with ndMM and relapsed refractory multiple myeloma (rrMM), treated at the University Hospital of Bern (Inselspital). Next generation sequencing was performed on bone marrow, as part of routine diagnostics. The NGS panel comprised eight genes CCND1, DIS3, EGR1, FAM46C (TENT5C), FGFR3, PRDM1, TP53, TRAF3 and seven hotspots in BRAF, IDH1, IDH2, IRF4, KRAS, NRAS. The primary endpoint was complete remission (CR) after VRd in ndMM, in correlation with mutational profile. Mutational load was generally higher in rrMM, with more frequently mutated TP53: 11/87 (13%) in ndMM versus 9/11 (81%) in rrMM (OR 0.0857, p = 0.0007). In ndMM, treated by VRd, mutations in MAPK‐pathway members (NRAS, KRAS or BRAF) were associated with reduced probability of CR (21/38, 55%), as compared with wild type NRAS, KRAS or BRAF (34/40, 85%; OR 0.2225, p = 0.006). NRAS c.181C > A (p.Q61K) as a single mutation event showed a trend to reduced probability of achieving CR (OR 0.0912, p = 0.0247). Activation of MAPK pathway via mutated NRAS, KRAS and BRAF genes seems to have a negative impact on outcome in ndMM patients receiving VRd therapy. VRd* ‐ bortezomib (Velcade®), lenalidomide (Revlimid®) and dexamethasone.
Investigating the implementation of telehealth and digital technologies during public health crisis: A qualitative review
Authors: Anthony Jnr Bokolo 
Published: July 2023

AbstractPublic health crises such as the Coronavirus disease 2019 (COVID‐19) pandemic across the world overstrained the health care system. Accordingly, telehealth and digital technologies were implemented. Telehealth and digital technologies refer to the provision of health care at a distance using electronic means for diagnosis, evaluation, treatment, monitoring, and education of patients. This approach, while extremely useful, can be challenging for both patients and physicians, mainly as this is a new mode of health care to health practitioners and patients. Intrinsically, when managing the massive disruption to the routine of patient health care workflow, it is important to understand the important factors associated with an accelerated introduction of telehealth and digital technologies for the effective and safe continuation of healthcare during a public health crisis. Accordingly, this current study performed a qualitative review analysis of 40 scientific sources from 2019 to 2022. Findings present health practitioners that implemented telehealth and digital technologies during the public health emergency. Additionally, findings from this study presents a workflow approach for telehealth visit cycle and also discusses the current telehealth and virtual applications being implemented during public health crisis. This study provides implications to support health care managers and policymakers of health centres to be virtually informed regarding digital applications being implemented by patients and health practitioners on how to implement an effective telehealth system during public health crises.
Validation of Frail Scale and comparison with hospital frailty risk score to predict hospital use in a cohort of older Australian women
Authors: Shebeshi Dinberu S. , Dolja‐Gore Xenia , Byles Julie 
Published: July 2023

AbstractIntroductionWith no standard frailty tool for clinical care, research and policymaking, identifying frail older people is a challenge.AimsThis study aimed to compare two validated scales, which are the Frail Scale and Hospital Frailty Risk Score (HFRS) for their ability in identifying frailty in older Australian women and predicting hospital use.MethodsThis study included older Australian women aged 75–95 years, who had unplanned overnight hospital admission as an index admission between 2001 and 2016. Data from the Australian Longitudinal Study on Women's Health (ALSWH) were linked with administrative hospital data to calculate HFRS (using the International Statistical Classification of Diseases, Australia Modification (ICD‐10‐AM) diagnostic codes) and the Frail Scale (using the ALSWH self‐reported survey).ResultsThe Frail Scale identified a higher proportion of older frail women (30.54%) compared to the HFRS (23.0%). Frail older women, classified by Frail Scale, were at higher risk of long hospital stay (adjusted odds ratio = 1.28, 95% CI = 1.02–1.60), repeated admission (adjusted hazard ratio [AHR] = 1.30, 95% CI = 1.03–1.41) and death (AHR = 1.70, 95% CI = 1.45–2.01). HFRS was associated with longer hospital stay and mortality.ConclusionsThe proportion of older women classified as frail by the Frail Scale tool was higher than women classified as frail by HFRS. The Frail Scale and HFRS were not significantly associated with each other. While both tools were associated with the risk of long hospital stay and mortality, only the Frail Scale predicted the risk of repeated admission.
Childhood fantasy play relates to adult socio‐emotional competence
Authors: Halliday Abigail , Kola‐Palmer Susanna , Davis Paige , King Nigel , Retzler Jenny 
Published: July 2023

AbstractChildhood fantasy play and creation of imaginary companions are thought to confer socio‐emotional benefits in children, but little is known about how they relate to socio‐emotional competence in adulthood. A total of 341 adults (81 males) aged 18 and above (M = 31.47, SD = 12.62) completed an online survey examining their fantasy play as a child, their childhood imaginary companion status, and their adult socio‐emotional competence. Adults who reported higher levels of childhood fantasy play were found to be significantly more prosocial, empathetic, and emotionally intelligent than their counterparts after controlling for demographic factors. Recall of a childhood imaginary companion, however, was significantly related only to higher scores for perspective‐taking and did not explain unique variance in any adult competence measure. Findings suggest that engagement in fantasy play during childhood may be a precursor to later socio‐emotional competence, while benefits previously associated with imaginary companions specifically may not extend into adulthood.
Considerations for the inclusion of metabarcoding data in the plant protection product risk assessment of the soil microbiome
Authors: Sweeney Christopher J. , Kaushik Rishabh , Bottoms Melanie 
Published: July 2023

Abstract
There is increasing interest in further developing the plant protection product (PPP) environmental risk assessment, particularly within the European Union, to include the assessment of soil microbial community composition, as measured by metabarcoding approaches. However, to date, there has been little discussion as to how this could be implemented in a standardized, reliable, and robust manner suitable for regulatory decision-making. Introduction of metabarcoding-based assessments of the soil microbiome into the PPP risk assessment would represent a significant increase in the degree of complexity of the data that needs to be processed and analyzed in comparison to the existing risk assessment on in-soil organisms. The bioinformatics procedures to process DNA sequences into community compositional data sets currently lack standardization, while little information exists on how these data should be used to generate regulatory endpoints and the ways in which these endpoints should be interpreted. Through a thorough and critical review, we explore these challenges. We conclude that currently, we do not have a sufficient degree of standardization or understanding of the required bioinformatics and data analysis procedures to consider their use in an environmental risk assessment context. However, we highlight critical knowledge gaps and the further research required to understand whether metabarcoding-based assessments of the soil microbiome can be utilized in a statistically and ecologically relevant manner within a PPP risk assessment. Only once these challenges are addressed can we consider if and how we should use metabarcoding as a tool for regulatory decision-making to assess and monitor ecotoxicological effects on soil microorganisms within an environmental risk assessment of PPPs. Integr Environ Assess Manag 2024;20:337–358. © 2023 SETAC
Using spatiotemporal ratio analyses to quantitatively estimate water quality recovery of the Rio Doce
Authors: Wild Michael , Rouhani Shahrokh , Oehrig Jacob , Alves Pedro H. G. , Odle William , Gaspar Diogo F. A. 
Published: July 2023

Abstract
The Fundão Dam breached on 5 November 2015 (the “Event”), resulting in the release of tailings, water, scoured sediment and/or soil, and other debris to downstream watercourses. Statistical analyses using historical and recent water quality measurements were conducted to assess the extent to which water quality in the Rio Doce was recovering to baseline conditions. A review of station- and/or parameter-specific water quality time series in the Rio Doce revealed two challenges: pre-Event data imbalance and seasonality. Due to the combined effects of these two factors, data gathered from Rio Doce water quality stations before the Event likely underestimated concentration ranges and limited the usefulness of common recovery assessment techniques such as times series and water quality standard exceedance analyses. These challenges were addressed by calculating quarterly and watershed-specific river-to-tributary ratios. R code was used to produce spatiotemporal time series for 44 investigated parameters that were measured both before and after the Event. The water quality recovery durations shown by the parameter- and/or region-specific river-to-tributary ratio time series indicated that (a) turbidity provides the most conservative measure for water quality recovery; (b) chemical parameters associated with the tailings, like manganese and iron recovered faster than turbidity; and (c) other investigated parameters unrelated to the tailings showed either no discernable impact or rapid recovery after the Event. The resulting parameter- and/or region-specific river-to-tributary ratio time series provided reliable and quantifiable estimates of water quality recovery durations. The water quality in the region furthest from Fundão Dam, in Espírito Santo, recovered one year after the Event, while water quality in the closest region to Fundão Dam, upstream of Risoleta Neves (Candonga) Dam, recovered 4.2 years after the Event. Integr Environ Assess Manag 2024;20:74–86. © 2023 Newfields Companies, LLC. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
The effect of CEO‐to‐worker pay disparities on CEO compensation: The mediating role of shareholder say on pay votes
Authors: Develay Etienne , Wang Yan , Giamporcaro Stephanie 
Published: July 2023

AbstractIn response to large pay disparities caused by rising CEO compensation and stagnant employee pay, US financial regulators have taken several initiatives to mobilise shareholders. However, the ability of these initiatives to enhance shareholder engagement and reduce excessive CEO compensation has been questioned. Using a large sample of 1594 non‐financial firms from the Russell 3000 index over 2013–2019, we disentangle the complex role that shareholder engagement towards CEO‐to‐worker pay disparities plays on CEO compensation. We find that higher CEO‐to‐worker pay disparities increase shareholder dissent say on pay votes and that, paradoxically, shareholder dissent say on pay votes increase CEO compensation. Furthermore, we provide evidence that shareholder engagement mediates the relationship between CEO‐to‐worker pay disparities and CEO compensation through their say on pay votes. Our findings are consistent with the relative deprivation theory as shareholders react to large pay disparities to avoid the negative consequences of a feeling of deprivation on employees. They are also in line with the agency theory, as shareholder reactions to large CEO‐to‐worker pay disparities trigger reactions from the remuneration committee to better align CEO pay with their interests. Overall, our findings support the existence of a shareholder engagement channel driven by social comparison mechanisms and agency responses. This study has important implications for regulators by unpacking the usefulness of these regulatory initiatives to shareholders and also documenting their unintended consequences on CEO compensation.
A review of biomodified or biomimetic polymer dots for targeted fluorescent imaging and disease treatments
Authors: Guo Jintong , Du Meng , Chen Zhiyi , Chen Xueli , Yuan Zhen 
Published: July 2023

AbstractDue to their inherent tunable spectrum, high brightness, excellent biostability and biocompatibility, and functionalization of surfaces, semiconducting polymer dots (Pdots) are now playing an essential role in fluorescent (FL) imaging and disease treatment through bioconjugation with peptides or biomimetic materials. In particular, biomimetic Pdots exhibit their capability in targeted imaging of lesion and increased efficacy for targeting disease treatment. This review will inspect the recent advances in the design and functionalization strategies of biomodified and biomimetic Pdots for enhanced disease detection and therapy. More importantly, the application of these two modifications in targeted FL imaging and cancer treatment is to be addressed in detail. Meanwhile, the main challenges and prospects of biomimetic and biomodified Pdots are to be discussed, which will pave a new avenue for improved disease detection and imaging‐guided treatment.
Comment on “A posteriori localization of many‐body excited states through simultaneous diagonalization”
Authors: Wang Yu‐Chen , Feng Shishi , Liang WanZhen , Zhao Yi 
Published: July 2023

AbstractWe comment on an excited‐state localization method recently proposed by Blanc et al. (J. Comput. Chem. 2023, 44, 105). Elaborate comparisons are made to demonstrate that their method is a less‐comprehensive version of the diabatization method proposed by us 2 years earlier (J. Phys. Chem. Lett. 2021, 12, 1032).
Diffuse large B‐cell lymphoma in large intestine presenting as multiple polypoid lesions
Authors: Yang Rui , Lan Tian , Tong Huan 
Published: July 2023

AbstractA solitary large ulcerated mass is the common morphological feature of diffuse large B‐cell lymphoma (DLBCL) in the large intestine under endoscopy. Here we report a 54‐year‐old man with DLBCL presenting with multiple polypoid lesions in the large intestine, which is an uncommon morphological form of DLBCL.
Late‐stage functionalization of Vouacapane derivatives from Caesalpinia platyloba by a Groebke−Blackburn−Bienaymé reaction
Authors: Servín‐García Gabriela , Chacón‐García Luis , Islas‐Jácome Alejandro , Gómez‐Hurtado Mario A. , Rodríguez‐García Gabriela , del Río Rosa E. , Cortés‐García Carlos J. 
Published: July 2023

AbstractAn almost underexplored field within the natural products area is the synthesis of pseudo‐natural product libraries by employing isocyanide‐based multicomponent reactions as powerful synthetic tools and natural products or their functionalized derivatives as starting reagents. In this work, a novel synthetic strategy behind the late‐stage functionalization of fused Vouacapane‐azoles in a two‐step reaction was developed. The first reaction is a Vilsmeier–Haack formylation at furan ring of the natural product 6β‐acetoxyvouacapane, which was isolated from the leaves of Caesalpinia platyloba from its dichloromethane extracts. The second reaction was a Groebke–Blackburn–Bienaymé reaction to synthesize the pseudo‐natural products 11a‐f in moderate yields, containing pharmacophoric fragments furan and imidazo[1,2‐a]pyridine. The compounds described here are good candidates for biological activity assays.