bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the nexus between medical education and complexity: a systematic review to inform practice and research.
Authors: Ogden Kathryn , Kilpatrick Sue , Elmer Shandell 
Published: June 2023

Abstract
Background: Medical education is a multifarious endeavour integrating a range of pedagogies and philosophies. Complexity as a science or theory (‘complexity’) signals a move away from a reductionist paradigm to one which appreciates that interactions in multi-component systems, such as healthcare systems, can result in adaptive and emergent outcomes. This examination of the nexus between medical education and complexity theory aims to discover ways that complexity theory can inform medical education and medical education research.
Methods: A structured literature review was conducted to examine the nexus between medical education and complexity; 5 databases were searched using relevant terms. Papers were included if they engaged fully with complexity as a science or theory and were significantly focused on medical education. All types of papers were included, including conceptual papers (e.g. opinion and theoretical discussions), case studies, program evaluations and empirical research. A narrative and thematic synthesis was undertaken to create a deep understanding of the use of complexity in medical education.
Results: Eighty-three papers were included; the majority were conceptual papers. The context and theoretical underpinnings of complexity as a relevant theory for medical education were identified. Bibliographic and temporal observations were noted regarding the entry of complexity into medical education. Complexity was relied upon as a theoretical framework for empirical studies covering a variety of elements within medical education including: knowledge and learning theories; curricular, program and faculty development; program evaluation and medical education research; assessment and admissions; professionalism and leadership; and learning for systems, about systems and in systems. Discussion: There is a call for greater use of theory by medical educators. Complexity within medical education is established, although not widespread. Individualistic cultures of medicine and comfort with reductionist epistemologies challenges its introduction. However, complexity was found to be a useful theory across a range of areas by a limited number of authors and is increasingly used by medical educators and medical education researchers. This review has further conceptualized how complexity is being used to support medical education and medical education research. Conclusion: This literature review can assist in understanding how complexity can be useful in their own practice.
Identification of a Novel Disulfideptosis-Related LncRNA Signature and Integrative Analyses in Patients with Gliomas
Authors: Cao Kai-hua , Li Sai , Liu Qi , Wang Jia-Wei , Wan Jing-hai 
Published: June 2023

AbstractGlioma, a prevalent type of brain cancer, is associated with poor prognosis. The purpose of this study was to investigate the correlation between disulfidptosis-related lncRNAs (DRLncs) and survival outcomes of glioma patients. Transcriptome and clinical data for glioma patients were retrieved from The Cancer Genome Atlas (TCGA) database. Ten disulfidptosis-related genes (DRGs) were identified from literature. Co-expression analysis was performed to identify DRLncs associated with glioma. A risk prognostic model for DRLncs was constructed using COX regression analysis and LASSO regression analysis. The model was validated by dividing samples evenly into training and test groups and conducting various analyses including survival analysis, ROC curve analysis, independent prognostic analyses, and PCA. GO and KEGG enrichment analysis was also performed on differentially expressed genes between high-risk and low-risk groups. Variances in the immune microenvironment, immune cells, and immune-related functions were analyzed between high-risk and low-risk groups. Drug sensitivity analysis was conducted to identify potential therapeutic drugs for glioma treatment, and the TIDE database was used to evaluate the potential for immune escape. The expression of DRLncs in glioma was verified through real-time quantitative PCR. Through co-expression analysis, 136 disulfidptosis-related LncRNAs were identified. Univariate Cox analysis revealed that 86 of these LncRNAs significantly correlated with overall survival (OS) in glioma patients. Using the Lasso-Cox method, a model consisting of 7 LncRNAs was constructed and optimized. This model effectively differentiated between individuals at high risk and those at low risk, with good survival prediction ability. GO and KEGG analysis indicated that the differential gene enrichment in the high- and low-risk groups was related to immune-related functions. The study observed divergences in the immune microenvironment, immune cells, and immune-related functions between the high-risk and low-risk groups. Furthermore, immunotherapy response scoring indicated that patients in the low-risk group exhibited better response to immunotherapy. Finally, real-time quantitative PCR results showed that the expression of low-risk LncRNA (ZBTB20-AS4) was low in tumor tissue, while the expression of high-risk LncRNAs (POLR2J4, SUCLG2-AS1, and UBA6-AS1) was high in glioma tumor tissue. Overall, this study established a novel glioma prognosis model that explored disulfidptosis-related lncRNAs to guide glioma prognosis.
Semantic Segmentation of Cloud Images captured with Horizon-Oriented Cameras for Nowcasting Applications
Authors: Martins Bruno Juncklaus , Arrais Juliana Marian , Cerentini Allan , Mantelli Sylvio , Neto Gilberto Perello Ricci , von Wangenheim Aldo 
Published: June 2023

Abstract
The goal of this research is to create a cloud identification model for short-term solar power generation forecasting using deep learning methods. Deep learning techniques such as U-net, HRnet, and Detectron2 were used to perform semantic and instance segmentation of clouds. Transfer learning was employed, with weights trained on the "2012 ILSVRC ImageNet" dataset and architecture configurations such as Resnet, Efficient, and Mask RCNN. As a validation metric, the models were trained using the Jaccard Coefficient. The best model, a U-net with Resnet18 at 486x648 resolution, achieved an average Intersection over Union (IoU) of 0.6, indicating good cloud segmentation performance. All models were affected by the data imbalance, with the tree class causing a favorable bias towards the overall results. The HRNet model demonstrated refined pixel-level segmentation but was ineffective at detecting dominant clouds. This research provides insights into effective cloud identification techniques and lays the groundwork for future cloud classification model development. The model may be able to predict cloud motion. For future works the team will investigate dataset balancing and data augmentation transformations for model improvement. The research demonstrates the effectiveness of deep learning in cloud identification for solar power forecasting.
Natural and Synthetic Peptides to Control Drug-resistant Pathogens
Authors: de Sousa Francisca J.F. , Costa Igor R.S. , Cavalcante Francisco L.P. , Silva Ana J.O. , Brito Daiane M.S. , da Silva José Y.G. , Silva José J.L. , Almeida Camila G.L. , Mesquita Felipe P. , Souza Pedro F.N. 
Published: June 2023

Abstract:
Due to the excessive and inappropriate use of antibiotics in farming and clinic, pathogens
developed resistance mechanisms to currently used drugs. Thus, because of this resistance,
drugs become ineffective, leading to public health problems worldwide. According to the World
Health Organization (WHO), microbial resistance to drugs is one of the most threats that humanity
must face. Therefore, it is imperative to seek alternative methods to overcome microbial resistance.
Here, the potential of natural or synthetic antimicrobial peptides to overcome microbial resistance
will be discussed, and how peptides could be a source for new therapeutics molecules. In this context,
antimicrobial peptides (natural or synthetic) are considered promising molecules based on
their antifungal, antiviral, and antibacterial properties, making them eligible for developing new
drugs. In addition, they can act synergistically with existing drugs on the market, revealing a broad
spectrum of applications.
Association between Proinflammatory Cytokines and Anxiety and Depression Symptoms in Rheumatoid Arthritis Patients: A Cross-sectional Study
Authors: Parlindungan Faisal , Hidayat Rudy , Ariane Anna , Shatri Hamzah 
Published: June 2023

Background:
Rheumatoid arthritis (RA) patients have a greater prevalence of anxiety and depression. Proinflammatory cytokines are elevated in RA. We aim to evaluate the association between systemic inflammation in RA and anxiety and depression.

Methods:
There were 31 RA patients, 16 with active disease activity and 15 in remission state; they were assessed using the Hospital Anxiety and Depression Scale and for RA disease activity using Disease Activity Score of 28 joints (DAS28) – CRP (C-reactive protein). Serum proinflammatory cytokines were measured, including interleukin (IL)-6, IL-17, and Tumour Necrosis Factor-alpha (TNF-α).

Results:
Among 31 patients, ten patients showed anxiety symptoms, 19 patients showed depression symptoms, and two displayed mixed symptoms. Serum TNF-α levels were significantly higher in active disease than in the remission group (p-value 0.006). There was no association or correlation between proinflammatory cytokines to anxiety and depression symptoms in the active disease and remission groups.

Conclusion:
This suggests that other factors besides disease activity and state of systemic inflammation may cause anxiety and depression in RA patients.
Clinical and Radiological Benefits of Hyaluronic Acid in Periodontal Infrabony Defects: A Systematic Review and Meta-analysis
Authors: Aldahlawi Salwa A. 
Published: June 2023

Purpose:There is no consensus on the clinical and radiological benefits of hyaluronic acid (HA) in patients with periodontitis having infrabony defects. Hence, this study examined the effects of HA in periodontitis patients with infrabony defects through a comprehensive systematic review process.Methodology:A systematic literature search was performed using PubMed/Medline, Scopus, Embase and Cochrane Library from inception to March 2022. Randomized or non-randomized clinical trials and single-arm clinical trials that assessed the clinical and radiological benefits of HA in periodontitis patients with infrabony defects with a minimum of 6 months follow-up were included in this study. Surgical regenerative therapy was considered as the comparator. The Cochrane risk of bias assessment tool and Downs and Black checklist was used for the quality assessment of randomized and non-randomized interventional studies, respectively. A subgroup and sensitivity analyses were performed to explore the heterogeneity and robustness of the findings, respectively.Results:A total of 13 out of 725 studies were included in this systematic review, of which 9 were considered for meta-analysis. The meta-analysis indicated significant benefits of HA in terms of reduction in probing pocket depth (SMD: 1.12 mm; 95% CI: 0.60-1.65; 9 studies), bone defect depth (SMD: 1.04mm; 95%CI: 0.62-1.47; 3 studies) and gain in clinical attachment level (1.04 mm; 95% CI: 0.33-2.47; 8 studies). Overall, the quality of included studies was good.Conclusion:The current evidence indicates that the administration of HA in the periodontal regenerative treatment of infrabony defects was significantly effective in increasing clinical attachment levels and reducing probing pocket and bone defect depth.
Efficacy of bile salt hydrolase synthesizing probiotic bacteria in the treatment of irritable bowel syndrome with diarrhea
Authors: Polishchuk S.P. , Neverovskyi A.V. 
Published: June 2023

Background. One of the mechanisms of the of irritable bowel syndrome with diarrhea (IBS-D) is bile acid malabsorption (BAM). In addition to the use of bile acid sequestrants, probiotic bacteria synthesizing bile salt hydrolase (BSH) are promising in the treatment of probable BAM. The purpose of the study was to compare the effectiveness of combined treatment (a probiotic based on strains of Lactobacillus, Streptococcus, Bifidobacterium, Saccharomyces boulardii and cholestyramine) with cholestyramine monotherapy in the treatment of IBS-D. Materials and methods. A 12-week randomized study included 108 patients with IBS-D divided into a control group (n = 51) receiving only cholestyra­mine and an experimental group (n = 57) receiving a combination of cholestyramine and the study probiotic. At baseline, the relative activity of BSH of the study probiotic capsules was determined. During the stages of the study, patients were examined using clinical scales. Results. The relative activity of BSH of the capsules with the studied probiotic was (2.07 ± 0.06) U/ml compared to (1.00 ± 0.04) U/ml of capsules with L.plantarum and (0.03 ± 0.01) U/ml — with L.plantarum without BSH genes. In the experimental group, the severity of bloating and visceral sensitivity index were lower after 8 and 12 weeks, and the value of the stool type according to the Bristol scale and its daily frequency — after 12 weeks compared to the control group, p < 0.05. According to the scale of IBS-adequate relief, the percentage of achieving a clinical effect was higher in the experimental group compared to the controls after 12 weeks, odds ratio was 1.31 (95% confidence interval 1.03–1.68), p = 0.038. Conclusions. Additional prescription of a probiotic with BSH synthesizing bacterial strains is more effective in improving clinical manifestations of IBS-D and achieving a therapeutic effect compared to cholestyramine monotherapy.
La igualdad en la Agenda 2030: un reto histórico del Estado
Authors: Herrera-Camargo Lyda Marcela 
Published: June 2023

El presente artículo plantea una reflexión sobre los retos del Estado frente al cumplimiento de la agenda 2030 en torno a la búsqueda de igualdad, dadas las contradicciones que se dan en esta desde su origen y hasta el actual escenario capitalista del siglo XXI, abordando para ello cuatro ejes de análisis: los derechos humanos, el desarrollo, las políticas públicas y la participación.
La metodología de análisis implica una revisión documental que aborda antecedentes históricos y su influencia en la actualidad, retoma planteamientos críticos y aportaciones de estudios con énfasis en América Latina que evidencian la diferencia entre lo planteado como objetivos universales y la realidad capitalista que viene desde la modernidad, hace alusión al esfuerzo colombiano por cumplir estas políticas.
El método utilizado consiste en el relacionamiento entre la crítica teórica de cada uno de los conceptos, su relación con la agenda 2030 y el contexto colombiano.
Las conclusiones muestran problemas del sistema capitalista desde su puesta en marcha y los desafíos estructurales vigentes en los territorios y pobladores en América Latina hasta los aspectos que dan real importancia a la humanidad y al medio ambiente los cuales están en inminente peligro.
The incidence of physeal fractures in the lower limb and the frequency of premature physeal closure: a cohort study of 236 patients
Authors: Cant David A L W , Faergemann Christian 
Published: June 2023

Background and purpose: Physeal fractures represent 15–20% of all pediatric fractures and may lead to premature physeal closure (PPC). The aim of our study was to determine the incidence rates of physeal fractures in the lower limb and the proportion of PPC that lead to limb length discrepancy (LLD), and/or angular deformity (AD).Patients and methods: This retrospective study included 236 consecutive children with physeal fracture in the tibia, distal femur, or distal fibula. We estimated incidence rates and reviewed medical records and radiographs to obtain information regarding the development of PPC leading to LLD and AD. Of the 236 children, 100 had planned growth control or were referred for growth control due to symptoms of PPC.Results: The total incidence rate was 35 (95% CI 30–39) per 100,000 person-years, with 1.2 (CI 0.5–23) for distal femur, 5.7 (CI 3.1–7.8) for proximal tibia, 14 (CI 11–17) for distal tibia, and 14 (CI 11–17) for distal fibula. The overall prevalence of PPC was 9.7% (CI 6.3–14), while the prevalence was 38% (CI 8.5–76) for distal femur, 15% (CI 5.9–31) for proximal tibia, 14% (CI 7.4-–22) for distal tibia, and 1.1% (CI 0.3-–59) for distal fibula. We found a significant higher hazard of PPC in fractures with ≥ 3 mm displacement (hazard ratio: 12, CI 1.5–97).Conclusion: 10% of children with physeal fractures developed PPC that led to LLD or AD. The highest hazard ratio was in children who had an initial fracture displacement. This study highlights the importance of routine and uniform growth evaluation after a physeal fracture
Bildandet av professionellt omdöme: om den levda kroppen som utgångspunkt och resurs
Authors: Pröckl Maria 
Published: June 2023

En professionsutbildning på högskola har alltid det framtida yrket i sikte. Det finns i snart sagt allt en koppling mellan det som studenterna läser och övar sig på och det som den yrkeskår studenten kommer att tillhöra gör på daglig basis. De framtida yrkesutövarna inom det mellanmänskliga fältet – som kan vara exempelvis lärare, poliser eller vårdpersonal – lär sig på högskolan det de behöver veta, kunna och vara förtrogna med för att fungera inom sitt blivande yrke. Men hur övas det som kanske är det viktigaste? Hur övas omdömesförmågan, blicken för vad som har betydelse i en situation och känslan för yrkets komplexitet? Var i utbildningen blir det föremål för undervisning och hur utvecklar högskolestudier det professionella omdömet? Den här essän beskriver det reflekterande seminariet som ett sätt att öva det professionella omdömet. Utgångspunkten är en fenomenologiskt infärgad förförståelse att studentens levda erfarenhet av att vara en människa bland människor erbjuder stora möjligheter att arbeta med utveckling av professionellt omdöme. Utifrån den praktiska kunskapens teori undersöks möjligheterna som en ”som om”-kontext ger seminariet i syftet att undersöka och reflektera över det framtida yrkets mellanmänskliga utmaningar.
ENGLISH ABSTRACT
The reflective seminar as a way to practice professional judgment
A professional education always has the student’s future profession in sight. In almost all aspects, there is a connection between what is studied and practiced, and what the forthcoming professional guild does on a daily basis. Practitioners in the making in the so-called interpersonal field – as for example teachers, police officers or professionals in healthcare – study what they need to know theoretically and practically to manage their future profession. But how is the very important task to develop the student’s professional judgement conducted? How is the professional gaze, or the sensibility for making sense of complex situations developed in university? Where in the educational setting does this take place? This essay describes the reflective seminar as a way to practice professional judgment. The starting point is a phenomenologically colored understanding that the student’s lived experience of being a person amongst persons offers great opportunities to work on the development of professional judgment. Moving from the theory of practical knowledge we investigate the possibilities that a “as if ” context gives the seminar. This we do to examine and reflect on the interpersonal challenges that the student’s future profession might harbor.
Integrating Diffusion Perspective of Total Quality Management Improvement in SMEs Indonesia Sector: a Bibliometric Analysis
Authors: Subagio Hartono 
Published: June 2023

Pupose: Constructing big potential of development by boosting up the SMEs. The SMEs seems neglected by its history as the main focus remained on public sectory. The SMEs particularuy in large scale manufacturing units beyond the government, bank, and liberalization. As the SMEs sector periodly withdraw their development because of lack skill and function. In this research, SMEs sector an object using the improvement of Entreprenurship skill by Human Capital and Social Resources, and Enterpreneurship Education.
Method: This research adopts qualitative research method with Bibliometric Analysis. Bibliometric analysis defines the quality of systematic literature with periodical time and quality evidence in empirical studies.
Result: Adopting the Systematic Literature and Bibliometric analysis entrepreneurship could responsibility of reality in better recognize and understand the potentional of implementation process. With an evidences by integrating diffusion perspective between Total Quality Management in Indonesia SMEs sector.
The Rise of Food & Beverages MSMEs During COVID-19 Pandemic in Tanjungpinang, Kepulauan Riau : A Motivational Perspective
Authors: Muhammad Rizki  , Satriadi Satriadi , Saputra Eka Kurnia 
Published: June 2023

Abstract
Purpose: This study aims to explore the entrepreneurial motivation behind food and beverage MSMEs in Tanjungpinang during the COVID-19 pandemic.
Method: This study adopted a qualitative method. A total of 11 food and beverage MSMEs owners in Tanjungpinang that started their businesses in 2020 and 2021 were interviewed. Thematic analysis was used to analyze the data gathered.
Result: The result of this study shows that financial rewards, independence, personal satisfaction, as well as the existence of opportunities as the driving forces behind a person’s decision to become an entrepreneur in the food and beverages industry in Tanjungpinang during the COVID-19 pandemic. This finding hopefully may give insight into the motivation behind an individual decision to become an entrepreneur in the food and beverages industry and why the number of food and beverages MSMEs is increasing.
Ownership Structure on Dividend Policy in The Indonesian Stock Exchange
Authors: Vincent  , Wijaya Liliana Ingrit , Ria Murhadi Werner 
Published: June 2023

Purpose: This research analyses how ownership structure affects dividend policy.
Method: Quantitative with a pool least square (PLS) regression model was used as a research method, and the research sample was drawn from all non-financial sector companies registered in IDX from 2017 to 2021. Independent variables such as family ownership, institutional ownership, and concentration ownership. This research also has a control variable such as return on assets, debt to equity ratio, firm size, firm age, free cash flow, and volatility (business risk).
Result: This research found that family ownership, institutional ownership, concentration ownership, return on assets, firm size, age of firm, free cash flow, and volatility (business risk) all have a significant effect on dividend yield, but the debt to equity ratio has no effect.