bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of sentinel lymph node localization in malignant melanoma by preoperative semiconductor gamma camera and planar lymphoscintigraphy
Authors: Assam Isong , Dierck Simon P. , Zhao Yi , Jüptner Michael , Siebert Frank‐André , Zuhayra Maaz , Lützen Ulf 
Published: June 2023

AbstractIntroductionPerforming lymphoscintigraphy in a separate room, frees up the conventional gamma camera, coupled with the desire to directly localize sentinel lymph nodes (SLN) in the operating theatre has led to the development of high‐resolution semiconductor‐detector based handheld gamma‐cameras, CrystalCam.MethodsThis work consists of phantom and clinical studies. For the first part, a Jaszczak phantom with hollow spheres of various volumes were filled with the 99mTc and the camera's sensitivity was measured at various distances to assess the possibilities and limitations of the device. The clinical study evaluates the effectiveness of CrystalCam in localizing SLN in 40 consecutive malignant melanoma patients compared to both conventional planar lymphoscintigraphy and hybrid SPECT/CT. SLNs detected by planar lymphoscintigraphy were marked on the patients’ skin using a UV‐marker. CrystalCam images were acquired in another room by another examiner and the SLNs were marked with a felt pen. The detected nodes by both camera systems were evaluated using UV‐lamp and normal light to visualize the UV‐ and felt pen marks respectively. The concordance rate of the SLNs and higher‐echelon nodes localized by both planar scintigraphy and CrystalCam imaging with respect to the total SLNs and higher‐echelon nodes detected by SPECT/CT imaging are compared and statistically analyzed.ResultsThe results of the phantom study show a good correlation between activity and count‐rates for all distancesSPECT/CT, CrystalCamm, and planar lymphoscintigraphy detected 69, 58, and 61 SLNs respectively. The concordance rate of 95.65% by the CrystalCam and planar scintigraphy implies both cameras are statistically coequal in preoperative SLN detection of malignant melanoma. For the higher‐echelon nodes, SPECT/CT, planar and CrystalCam imaging systems identified 82, 48, and 13 respectively; thus, CrystalCam was statistically inferior to planar imaging.ConclusionThe handheld CrystalCam is a reliable instrument for localizing SLNs in surgical centers without an on‐site nuclear medicine department.
Risk of Malnutrition in Patients With Systemic Sclerosis‐Associated Interstitial Lung Disease Treated With Nintedanib in the Randomized, Placebo‐Controlled SENSCIS Trial
Authors: Volkmann Elizabeth R. , McMahan Zsuzsanna H. , Smith Vanessa , Jouneau Stéphane , Miede Corinna , Alves Margarida , Herrick Ariane L. ,   the SENSCIS Trial Investigators
Published: June 2023

ObjectiveTo assess adverse events (AEs) in relation to baseline body mass index (BMI) and the risk of malnutrition in patients with systemic sclerosis–associated interstitial lung disease (SSc–ILD) treated with nintedanib.MethodsAmong patients with SSc–ILD randomized to receive nintedanib or placebo in the SENSCIS trial, we assessed AEs in subgroups by baseline BMI ≤20 kg/m2 and BMI >20 kg/m2, and the risk of malnutrition using a modified version of the Malnutrition Universal Screening Tool (MUST), over 52 weeks.ResultsThe AE profile of nintedanib was similar between subgroups with a baseline BMI ≤20 kg/m2 (n = 61) and a baseline BMI >20 kg/m2 (n = 515). In these subgroups, respectively, AEs led to treatment discontinuation in 16.7% and 15.9% of the nintedanib group and 13.5% and 8.0% of the placebo group, respectively. Based on the modified MUST, the proportions of patients who had a low risk of malnutrition at baseline and at their last assessment were 74.0% in the nintedanib group and 78.1% in the placebo group, while the proportions who were classified as at low risk at baseline but at high risk by their last assessment were 4.5% in the nintedanib group and 1.0% in the placebo group.ConclusionIn the SENSCIS trial, most patients with SSc–ILD remained at low risk of malnutrition over 52 weeks, but the proportion at high risk was higher in patients who received treatment with nintedanib compared to those who received placebo. Management of disease manifestations and AEs that may be associated with weight loss is important to reduce the risk of malnutrition in patients with SSc–ILD.
Real‐World Evidence Assessing Psoriatic Arthritis by Disease Domain: An Evaluation of the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry
Authors: Mease Philip J. , O'Brien Jacqueline , Middaugh Nicole , Kricorian Gregory , Stryker Scott , Collier David H. , Ogdie Alexis 
Published: June 2023

ObjectiveReal‐world studies assessing treatment response by psoriatic arthritis (PsA) domains are limited. This study aimed to describe the patient characteristics, frequency and combinations of disease domains, disease activity, and patient‐reported outcomes (PROs) by PsA domains in patients who initiated treatment with a tumor necrosis factor inhibitor (TNFi) or interleukin‐17 inhibitor (IL‐17i).MethodsAdults with PsA who initiated treatment with a TNFi or an IL‐17i between January 2013 and January 2021 and had a 6 (±3)–month follow‐up were included. The prevalence of PsA domains, the most common domain combinations, treatment persistence, and unadjusted change in disease activity and PROs from baseline to 6 months for each PsA domain were summarized descriptively.ResultsOf the 1005 eligible patients, 63% were receiving TNFi and 37% were receiving IL‐17i. Forty percent of TNFi and 14% of IL‐17i initiators received these treatments as first‐line therapy. Peripheral arthritis and skin disease were the most common PsA domains identified in 86% and 82% of patients, respectively, and the triad of peripheral arthritis, skin disease, and nail psoriasis was the most common domain combination observed in 14% of patients. More than two thirds (68%) of patients remained on therapy at 6 months’ follow‐up. Improvements in disease activity and PROs were observed across all PsA domains in those receiving TNFi or IL‐17i.ConclusionThis real‐world analysis highlights the heterogeneity in domain presentation; therefore, assessing all PsA domains is important for optimal disease management. Improvements in outcomes across all PsA domains demonstrate the effectiveness of TNFi and IL‐17i in diverse patient groups exhibiting different phenotypes of PsA.
Erasable, Rewritable, and Reprogrammable Dual Information Encryption Based on Photoluminescent Supramolecular Host–Guest Recognition and Hydrogel Shape Memory
Authors: Yang Hailong , Li Shengnan , Zheng Jingxia , Chen Guoqi , Wang Wenquan , Miao Yueyue , Zhu Nannan , Cong Yang , Fu Jun 
Published: June 2023

AbstractInformation encryption technologies are very important for security, health, commodity, and communications, etc. Novel information encryption mechanisms and materials are desired to achieve multimode and reprogrammable encryption. Here, a supramolecular strategy is demonstrated to achieve multimodal, erasable, reprogrammable, and reusable information encryption by reversibly modulating fluorescence. A butyl‐naphthalimide with flexible ethylenediamine functionalized β‐cyclodextrin (N‐CD) is utilized as a fluorescent responsive ink for printing or patterning information on polymer brushes with dangling adamantane group grafted on responsive hydrogels. The photoluminescent naphthalimide moiety is bonded to β‐CD and entrapped in the cavity. Its fluorescence is highly weakened in β‐CD cavity and recovers after being expelled from the cavity by a competing guest molecule to emit bright green photoluminescence under UV. Experiments and theoretical calculations suggest π–π stacking and ICT as the primary mechanism for the naphthalimides assembly and fluorescence, which can be quenched through insertion of conjugated molecules and recover by removing the insert. Such reversible quenching and recovering are used to achieve repeated writing, erasing, and re‐writing of information. Supramolecular recognition and hydrogel shape memory are further combined to achieve reversible dual‐encryption. This study provides a novel strategy to develop smart materials with improved information security for broad applications.
Bacteria‐Derived Outer‐Membrane Vesicles Hitchhike Neutrophils to Enhance Ischemic Stroke Therapy
Authors: Pan Jingmei , Wang Zhenhua , Huang Xuehui , Xue Juan , Zhang Suling , Guo Xing , Zhou Shaobing 
Published: June 2023

AbstractThe treatment of reperfusion injury after ischemic stroke remains unsatisfactory since the blood‐brain barrier (BBB) prevents most neuroprotective agents from entering the brain. Here, a strategy is proposed based on bacteria‐derived outer‐membrane vesicle (OMV) hitchhiking on the neutrophils for enhanced brain delivery of pioglitazone (PGZ) to treat ischemic stroke. By encapsulating PGZ into OMV, the resulting OMV@PGZ nanoparticles inherit the functions associated with the bacterial outer membrane, making them ideal decoys for neutrophil uptake. The results show that OMV@PGZ simultaneously inhibits the activation of nucleotide oligomerization‐like receptor protein 3 (NLRP3) inflammasomes and ferroptosis and reduces the reperfusion injury to exert a neuroprotective effect. Notably, the transcription factors Pou2f1 and Nrf1 of oligodendrocytes are identified for the first time to be involved in this process and promoted neural repair by single‐nucleus RNA sequencing (snRNA‐seq).
An Ultrafast, Energy‐Efficient Electrochromic and Thermochromic Device for Smart Windows
Authors: Deng Bin , Zhu Yanan , Wang Xiaowei , Zhu Jinlin , Liu Manyu , Liu Mingqiang , He Yaowu , Zhu Caizhen , Zhang Chaohong , Meng Hong 
Published: June 2023

AbstractSmart windows nowadays undertake the esteemed obligation of reducing energy consumption as well as upgrading living experience. This project aims to devise a smart window that responds to both electricity and heat, with the intention of achieving energy efficiency, privacy preservation, and enhanced decorative attributes. Through the implementation of a novel electrochromic material design, coupled with the optimization of electrochromic devices (ECDs), a high‐performance ECD is obtained, demonstrating coloring/bleaching time of 0.53/0.16 s, a transmittance modulation of 78% (from 99% to 21%), and superior performance in six dimensions. Furthermore, temperature‐responsive units and an ionic liquid are incorporated into the electrolyte system to create a novel thermochromic gel electrolyte with transmittance modulation from 80% to 0%, and excellent thermal insulation (6.4 °C reduction). Ultimately, an electro‐ and thermochromic device is developed, featuring an ultrafast color‐switching speed of 0.82/0.60 s and multiple working modes. Overall, this work showcases a prospective design pathway for the development of next‐generation ultrafast‐switching, and energy‐efficient intelligent windows.
Biofluid‐Activated Biofuel Cells, Batteries, and Supercapacitors: A Comprehensive Review
Authors: Garland Nate T. , Kaveti Rajaram , Bandodkar Amay J. 
Published: June 2023

AbstractRecent developments in wearable and implanted devices have resulted in numerous, unprecedented capabilities that generate increasingly detailed information about a user's health or provide targeted therapy. However, options for powering such systems remain limited to conventional batteries which are large and have toxic components and as such are not suitable for close integration with the human body. This work provides an in‐depth overview of biofluid‐activated electrochemical energy devices, an emerging class of energy sources judiciously designed for biomedical applications. These unconventional energy devices are composed of biocompatible materials that harness the inherent chemistries of various biofluids to produce useable electrical energy. This work covers examples of such biofluid‐activated energy devices in the form of biofuel cells, batteries, and supercapacitors. Advances in materials, design engineering, and biotechnology that form the basis for high‐performance, biofluid‐activated energy devices are discussed. Innovations in hybrid manufacturing and heterogeneous integration of device components to maximize power output are also included. Finally, key challenges and future scopes of this nascent field are provided.
Liquid‐Like Li‐Ion Conduction in Oxides Enabling Anomalously Stable Charge Transport across the Li/Electrolyte Interface in All‐Solid‐State Batteries
Authors: Wu Jian‐Fang , Zou Zheyi , Pu Bowei , Ladenstein Lukas , Lin Shen , Xie Wenjing , Li Shen , He Bing , Fan Yameng , Pang Wei Kong , Wilkening H. Martin R. , Guo Xin , Xu Chaohe , Zhang Tao , Shi Siqi , Liu Jilei 
Published: June 2023

AbstractThe softness of sulfur sublattice and rotational PS4 tetrahedra in thiophosphates result in liquid‐like ionic conduction, leading to enhanced ionic conductivities and stable electrode/thiophosphate interfacial ionic transport. However, the existence of liquid‐like ionic conduction in rigid oxides remains unclear, and modifications are deemed necessary to achieve stable Li/oxide solid electrolyte interfacial charge transport. In this study, by combining the neutron diffraction survey, geometrical analysis, bond valence site energy analysis, and ab initio molecular dynamics simulation, 1D liquid‐like Li‐ion conduction is discovered in LiTa2PO8 and its derivatives, wherein Li‐ion migration channels are connected by four‐ or five‐fold oxygen‐coordinated interstitial sites. This conduction features a low activation energy (0.2 eV) and short mean residence time (<1 ps) of Li ions on the interstitial sites, originating from the Li–O polyhedral distortion and Li‐ion correlation, which are controlled by doping strategies. The liquid‐like conduction enables a high ionic conductivity (1.2 mS cm−1 at 30 °C), and a 700 h anomalously stable cycling under 0.2 mA cm−2 for Li/LiTa2PO8/Li cells without interfacial modifications. These findings provide principles for the future discovery and design of improved solid electrolytes that do not require modifications to the Li/solid electrolyte interface to achieve stable ionic transport.
Multi‐Band Polarization‐Independent Quasi‐Bound States in the Continuum Based on Tetramer‐Based Metasurfaces and Their Potential Application in Terahertz Microfluidic Biosensing
Authors: Ding Jifei , Huang Lirong , Luo Yi , Wang Tianwu , Hu Jinkang , Li Runze , Xiao Shiyi 
Published: June 2023

AbstractQuasi‐bound state in the continuum (quasi‐BIC) has drawn increasing attention in terahertz biosensing and filtering owing to an extremely narrow linewidth and ultra‐high quality factor. However, it is usually polarization‐sensitive due to broken structure or incidence symmetry and mainly holds for polarization‐dependent single or dual bands, which sets a limitation on practical applications. Here, this article proposes and experimentally demonstrates terahertz multi‐band polarization‐independent quasi‐BICs in tetramer‐based metasurfaces by using the laser etching method. Employing a tetramer cluster with C4v symmetry as the structural unit, which consists of four L‐type copper particles on a flexible and optically‐transparent substrate, the metasurfaces can support dual‐band or tri‐band polarization‐independent quasi‐BICs after performing collective perturbation, specific displacement, or both to the constituent particles. Furthermore, the metasurfaces are integrated with microfluidic channels to explore their potential application in terahertz biosensing. Experimental results indicate that when the concentration of bovine serum albumin solutions is below 4 mg mL−1, both resonance modes of the dual‐band terahertz microfluidic biosensor exhibit a sensitivity of ≈12 GHz mg−1 mL each, and the detection limits reach 0.17 mg mL−1. This work provides a general and simple strategy to construct metasurfaces supporting multi‐band polarization‐independent quasi‐BICs, which have promising applications in biosensing, filtering, and lasing.
Reduction of Intracellular Tension and Cell Adhesion Promotes Open Chromatin Structure and Enhances Cell Reprogramming
Authors: Soto Jennifer , Song Yang , Wu Yifan , Chen Binru , Park Hyungju , Akhtar Navied , Wang Peng‐Yuan , Hoffman Tyler , Ly Chau , Sia Junren , Wong SzeYue , Kelkhoff Douglas O. , Chu Julia , Poo Mu‐Ming , Downing Timothy L. , Rowat Amy C. , Li Song 
Published: June 2023

AbstractThe role of transcription factors and biomolecules in cell type conversion has been widely studied. Yet, it remains unclear whether and how intracellular mechanotransduction through focal adhesions (FAs) and the cytoskeleton regulates the epigenetic state and cell reprogramming. Here, it is shown that cytoskeletal structures and the mechanical properties of cells are modulated during the early phase of induced neuronal (iN) reprogramming, with an increase in actin cytoskeleton assembly induced by Ascl1 transgene. The reduction of actin cytoskeletal tension or cell adhesion at the early phase of reprogramming suppresses the expression of mesenchymal genes, promotes a more open chromatin structure, and significantly enhances the efficiency of iN conversion. Specifically, reduction of intracellular tension or cell adhesion not only modulates global epigenetic marks, but also decreases DNA methylation and heterochromatin marks and increases euchromatin marks at the promoter of neuronal genes, thus enhancing the accessibility for gene activation. Finally, micro‐ and nano‐topographic surfaces that reduce cell adhesions enhance iN reprogramming. These novel findings suggest that the actin cytoskeleton and FAs play an important role in epigenetic regulation for cell fate determination, which may lead to novel engineering approaches for cell reprogramming.
Engineered Biomimetic Fibrillar Fibronectin Matrices Regulate Cell Adhesion Initiation, Migration, and Proliferation via α5β1 Integrin and Syndecan‐4 Crosstalk
Authors: Ahn Seungkuk , Sharma Upnishad , Kasuba Krishna Chaitanya , Strohmeyer Nico , Müller Daniel J. 
Published: June 2023

AbstractCells regulate adhesion to the fibrillar extracellular matrix (ECM) of which fibronectin is an essential component. However, most studies characterize cell adhesion to globular fibronectin substrates at time scales long after cells polarize and migrate. To overcome this limitation, a simple and scalable method to engineer biomimetic 3D fibrillar fibronectin matrices is introduced and how they are sensed by fibroblasts from the onset of attachment is characterized. Compared to globular fibronectin substrates, fibroblasts accelerate adhesion initiation and strengthening within seconds to fibrillar fibronectin matrices via α5β1 integrin and syndecan‐4. This regulation, which additionally accelerates on stiffened fibrillar matrices, involves actin polymerization, actomyosin contraction, and the cytoplasmic proteins paxillin, focal adhesion kinase, and phosphoinositide 3‐kinase. Furthermore, this immediate sensing and adhesion of fibroblast to fibrillar fibronectin guides migration speed, persistency, and proliferation range from hours to weeks. The findings highlight that fibrillar fibronectin matrices, compared to widely‐used globular fibronectin, trigger short‐ and long‐term cell decisions very differently and urge the use of such matrices to better understand in vivo interactions of cells and ECMs. The engineered fibronectin matrices, which can be printed onto non‐biological surfaces without loss of function, open avenues for various cell biological, tissue engineering and medical applications.
Design Strategies of Li–Si Alloy Anode for Mitigating Chemo‐Mechanical Degradation in Sulfide‐Based All‐Solid‐State Batteries
Authors: Kim Minhyung , Kim Min Ju , Oh Yeong Seon , Kang Sung , Shin Tae Ho , Lim Hyung‐Tae 
Published: June 2023

AbstractComposite anodes of Li3PS4 glass+Li–Si alloy (Type 1) and Li3N+LiF+Li–Si alloy (Type 2) are prepared for all‐solid‐state batteries with Li3PS4 (LPS) glass electrolyte and sulfur/LPS glass/carbon composite cathode. Using a three‐electrode system, the anode and cathode potentials are separated, and their polarization resistances are individually traced. Even under high‐cutoff‐voltage conditions (3.7 V), Type 1 and 2 cells are stably cycled without voltage noise for >200 cycles. Although cathode polarization resistance drastically increases after 3.7 V charge owing to LPS oxidation, LPS redox behavior is fairly reversible upon discharge–charge unlike the non‐composite alloy anode cell. Time‐of‐flight secondary ion mass spectrometry analysis reveals that the enhanced cyclability is attributed to uniform Li–Si alloying throughout the composite anode, providing more pathways for lithium ions even when these ions are over‐supplied via LPS oxidation. These results imply that LPS‐based cells can be reversibly cycled with LPS redox even under high‐cutoff voltages, as long as non‐uniform alloying (lithium dendrite growth) is prevented. Type 1 and 2 cells exhibit similar performance and stability although reduction product is formed in Type 1. This work highlights the importance of alloy anode design to prevent chemo‐mechanical failure when cycling the cell outside the electrochemical stability window.
Sulfated Polysaccharide Regulates the Homing of HSPCs in a BMP‐2‐Triggered In Vivo Osteo‐Organoid
Authors: Dai Kai , Zhang Wenchao , Deng Shunshu , Wang Jing , Liu Changsheng 
Published: June 2023

AbstractHematopoietic stem cell transplantation (HSCT) is a well‐established method for a variety of acquired and congenital diseases. However, the limited number and sources of therapeutic hematopoietic stem/progenitor cells (HSPCs) hinder the further application of HSCT. A BMP‐2 triggered in vivo osteo‐organoid that is previously reported, serves as a kind of stem cell biogenerator, for obtaining therapeutic HSPCs via activating the residual regenerative capacity of mammals using bioactive biomaterials. Here, it is demonstrated that targeting the homing signaling of HSPCs elevates the proportions and biological functions of HSPCs in the in vivo osteo‐organoid. Notably, it is identified that sulfonated chito‐oligosaccharide, a degradation product of sulfonated chitosan, specifically elevates the expression of endothelial protein C receptor on HSPCs and vascular cell adhesion molecule‐1 on macrophages in the in vivo osteo‐organoid, ultimately leading to the production of adequate therapeutic HSPCs. This in vivo osteo‐organoid approach has the potential to provide an alternative HSPCs source for HSCT and benefits more patients.
Phage‐Inducible Chromosomal Islands as a Diagnostic Platform to Capture and Detect Bacterial Pathogens
Authors: Ibarra‐Chávez Rodrigo , Reboud Julien , Penadés José R. , Cooper Jonathan M. 
Published: June 2023

AbstractPhage‐inducible chromosomal islands (PICIs) are a family of phage satellites that hijack phage components to facilitate their mobility and spread. Recently, these genetic constructs are repurposed as antibacterial drones, enabling a new toolbox for unorthodox applications in biotechnology. To illustrate a new suite of functions, the authors have developed a user‐friendly diagnostic system, based upon PICI transduction to selectively enrich bacteria, allowing the detection and sequential recovery of Escherichia coli and Staphylococcus aureus. The system enables high transfer rates and sensitivities in comparison with phages, with detection down to ≈50 CFU mL−1. In contrast to conventional detection strategies, which often rely on nucleic acid molecular assays, and cannot differentiate between dead and live organisms, this approach enables visual sensing of viable pathogens only, through the expression of a reporter gene encoded in the PICI. The approach extends diagnostic sensing mechanisms beyond cell‐free synthetic biology strategies, enabling new synthetic biology/biosensing toolkits.