bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sparse-Firing Regularization Methods for Spiking Neural Networks with Time-to-First-Spike Coding
Authors: Sakemi Yusuke , Yamamoto Kakei , Hosomi Takeo , Aihara Kazuyuki 
Published: August 2023

Abstract
The training of multilayer spiking neural networks (SNNs) using the error backpropagation algorithm has made significant progress in recent years. Among the various training schemes, the error backpropagation method that directly uses the firing time of neurons has attracted considerable attention because it can realize ideal temporal coding.
This method uses time-to-first-spike (TTFS) coding, in which each neuron fires at most once, and this restriction on the number of firings enables information to be processed at a very low firing frequency.
This low firing frequency increases the energy efficiency of information processing in SNNs.
However, only an upper limit has been provided for TTFS-coded SNNs, and the information-processing capability of SNNs at lower firing frequencies has not been fully investigated.
In this paper, we propose two spike-timing-based sparse-firing (SSR) regularization methods to further reduce the firing frequency of TTFS-coded SNNs.
Both methods are characterized by the fact that they only require information about the firing timing and associated weights.
The effects of these regularization methods were investigated on the MNIST, Fashion-MNIST, and CIFAR-10 datasets using multilayer perceptron networks and convolutional neural network structures.
A Category-Aware Network for Next POI Recommendation with Long- and Short-Term Preferences
Authors: Wang Yu , Liu An , Jiang Fan 
Published: August 2023

Abstract
As an important branch of recommendation systems, POI recommendation recommends the next Point of Interest (PoI) to users, which can effectively solve the problem of data redundancy in the information era. Researchers are committed to mining spatial-temporal information to model users' dynamic preferences and behavior patterns. However, suffering from the inherent sparsity issue of check-in records, existing methods only focus on spatial-temporal information and ignore the semantic information hidden in the users' check-in sequences. This kind of semantic information often embodies close relationship of user-POI and POI-POI. To this end, we introduce POI category information and propose a category-aware network with long- and short-term preferences (LSCAN for short) for next POI recommendation. By modeling the competition/cooperation relationship between POIs, we can have a deeper insight into user behavior patterns. Furthermore, the dynamic changes of users' interests, i.e., long-term and short-term preferences, play a significant role when users make decision. Therefore, we design a dynamic fusion mechanism to combine them. Finally, we study the performance of the proposed method on three real-world datasets. The experimental results show that LSCAN consistently outperforms the state-of-the-art approaches for next POI recommendation.
Adult-Type Neuronal Intranuclear Inclusion Disease with Limb Tremor Onset: Case Report and Literature Review
Authors: Wang Shuning , Zhu Hui , Liu Jingyao , Liu Hongping , Zhang Rensheng , Gao Hongyu , Wang Yushi , Li Yang 
Published: August 2023

Abstract
Background: Neuronal intranuclear inclusion disease (NIID) is a slowly progressing neurodegenerative disorder characterized by pathological features and eosinophilic intranuclear inclusions found in the central and peripheral nervous systems as well as in visceral organs. Herein, we report the case of a 62-year-old woman who presented with limb tremors and gradually developed cognitive impairment and unresponsiveness.
Case presentation: A 62-year-old woman was admitted to our hospital because of limb tremors for 7 years, along with mental disorders,slow reactions, and gait instability for 5 years. Brain magnetic resonance imaging revealed high-intensity signals in the corpus callosum and corticomedullary junction on diffusion-weighted imaging. Additionally, fluid-attenuated inversion recovery sequences showed high-intensity signals in the bilateral cerebellar vermis and middle cerebellar peduncle. Next, cerebrospinal fluid examination indicated a pressure of 95 mmH2O, positive Pandy’s test, glucose level of 4.0 mmol/L, protein level of 1100 mg/L, and chloride level of 122 mmol/L. Other laboratory tests showed no significant abnormalities. We considered a diagnosis of NIID. Subsequently, a skin biopsy was performed 10 cm above the left lateral malleolus. P62-immunoreactive abnormal material was confirmed in individual fibroblasts. Ultrathin sectioning and imaging revealed spherical, lightly stained, short filamentous inclusion structures in fibroblast nuclei. Genetic testing found pathogenic repetitions of GGC in NOTCH2NLC.
Conclusion: NIID is a rare clinically heterogeneous disease. In clinical work, a diagnosis of NIID should be considered when patients present predominantly with limb tremors and persistent abnormal high-intensity signals in the corpus callosum on diffusion-weighted imaging; NIID should especially be considered when patients do not demonstrate tendon reflexes. Long-term follow-up should be conducted to confirm the diagnosis, treatment, and prognosis of the disease.
Performance in Myoelectric Pattern Recognition Improves with transcranial Direct Current Stimulation
Authors: Damercheli Shahrzad , Morrenhof Kelly , Ortiz-Catalan Max 
Published: August 2023

Abstract
Sensorimotor impairments, resulting from conditions like stroke and amputations, can profoundly impact an individual’s functional abilities and overall quality of life. Assistive and rehabilitation devices such as prostheses, exo-skeletons, and serious gaming in virtual environments can help to restore some degree of function and alleviate pain after sensorimotor impairments. Myoelectric Pattern Recognition (MPR) has gained popularity in the past decades as it provides superior control over said devices, and therefore efforts to facilitate and improve performance in MPR can result in better rehabilitation outcomes. One possibility to enhance MPR is to employ transcranial Direct Current Stimulation (tDCS) to facilitate motor learning. Twelve healthy able-bodied individuals participated in this crossover study to determine the effect of tDCS on MPR performance. Baseline training was followed by two sessions of either sham or anodal tDCS using the dominant and non-dominant arms. Assignments were randomized, and the MPR task consisted of 11 different hand/wrist movements, including rest or no movement. Surface electrodes were used to record EMG and the MPR open-source platform, BioPatRec, was used for decoding motor volition in real-time. The Motion Test was used to evaluate performance. We hypothesized that using anodal tDCS to increase the excitability of the primary motor cortex associated with non-dominant side in able-bodied individuals, will improve motor learning and thus MPR performance. Overall, we found that tDCS enhanced MPR performance, particularly in the non-dominant side. We were able to reject the null hypothesis and improvements in the Motion Test’s Completion Rate during tDCS (28% change, p-value: 0.023) indicate its potential as an adjunctive tool to enhance MPR and motor learning. tDCS appears promising as a tool to enhance the learning phase of using assistive devices using MPR, such as myoelectric prostheses.
Effect of Nb2O5 coating on the corrosion resistance of the 7050-T7451 aluminium alloy
Authors: Ferreira Murilo Oliveira Alves , Teixeira Gabriella Terezinha Lima , Leite Natália Bueno , Gelamo Rogério Valentim , Pinto Haroldo Cavalcanti , Aoki Idalina Vieira , Moreto Jeferson Aparecido 
Published: August 2023

Abstract
The aircraft industry has been searching for new materials to be used in their aircrafts, which provide good mechanical and corrosive properties. The 7xxx series aluminium alloys are widely used in structural components. However, these alloys are susceptible to localised corrosion processes when exposed to an aggressive environment, which affect their lifetime and performance. Surface treatment appears as a powerful tool to improve the corrosion resistance of these alloys, since the coating may act as a protective physical barrier. This work aims to present an innovative and applied research for the development of the Nb2O5 thin films on the 7050-T7451 aluminium alloy surface by using the reactive sputtering technique. The open circuit potential, potentiodynamic polarization, electrochemical impedance spectroscopy as well as immersion tests were used to access the corrosion behaviour of the 7050-T7451 aluminium alloy in 0.6 mol L-1 NaCl solution. The morphology of the coated and uncoated specimens was verified by using optical microscopy, AFM and SEM/EDX techniques. Results demonstrated a difference of about 315 mV between the pitting potential (Epitting) and corrosion potential (Ecorr) for the coated material, indicating the positive effect of Nb2O5 thin films on the corrosion resistance of the alloy. In addition, EIS results displayed the reactive sputtering technique was advantageous, since the impedance modulus increased significantly. Finally, the EIS measurements corroborate with the AFM results, showing the Nb2O5 coating at the beginning of the corrosion tests is about 300 nm in thickness. To the best of our acknowledgement, this is the first study concerning the improvement of the corrosion properties of 7050-T7451 aluminium alloy by using the methodology presented in this work.
The influence of different production systems on welfare in a new layer hybrid
Authors: KURŞUN KADRİYE , Abdallah Nasir , Boga Yunus Emre , Baylan Mikail 
Published: August 2023

Abstract
This study was conducted to investigate the influence of two different production systems on the welfare of a new Turkish egg laying hybrid known as the Akbay. A total of 180 Akbay hens at the 80th wk of production either housed in conventional cages or in free range systems were used. Live body weight at the 80th wk of production, as well as the weight of immune organs and liver, was recorded. Plumage damage, foot lesions, stress, and fear were examined. The results revealed that the live body weight at the 80th wk of production was significantly (P ≤ 0.05) higher in the free-range birds compared to those housed in cages. The rectal temperature was significantly (P ≤ 0.05) higher in hens reared in the free-range systems than those housed in the conventional cages. The percentage of hens with mild to severe foot lesions was higher in the free-range system than in the conventional cages. Plumage damages were more common and severe among hens in cages than the free-range hens. No significant difference was recorded for tonic immobility (TI), the number of induction, and the duration of the first head movement during TI. The Fluctuating asymmetry and the weight of immune organs and liver were also not significantly different from each other. The housing of layer hens in the free range systems improved live body weight with a reduction in stress and feather damage. However, it is recommended that further studies should focus on the improvement of the foot lesion-related problems associated with this housing system.
Scalar fields as dark matter candidates in the modified left-right symmetry model
Authors: Istikomah Istikomah , Isnawati Nurul Embun 
Published: August 2023

Dark matter is about 25% of the universe, but its existence is still a mystery. The Modified Left-Right Symmetry Model with the extension of the scalar field, is expected to explain dark matter candidate. The dark matter candidates were analyzed using the Higgs Potential and Lagrangian Yukawa to obtain information on decay and scattering interactions. The generation of dark matter can be determined by analyzing the temperature evolution of the universe, which is divided into three stages post-inflation reheating, symmetry breaking first step, and symmetry breaking second step. The analysis results show that the right-sector scalar field can be Cold Dark Matter (CDM) candidate because it has non-relativistic characteristics, is stable, does not interact with fermions, and has an abundance of 0.004. The right-sector atom can also be a CDM candidate because it has non-relativistic characteristics, is neutral, and consists of the right nucleons and right electrons. The singlet scalar field can be the Warm Dark Matter (WDM) candidate because it can decay into fermion, interact in the left and right sectors, is neutrally charged and does not interact with other particles electromagnetically and has an abundance of 0.003. Thus, based on the modified left-right symmetry model, the particle that can be a candidate for dark matter is the scalar field.
Perceptions of and Preferences for Telemedicine Use Since the Early Stages of the COVID-19 Pandemic: Cross-Sectional Survey of Patients and Physicians
Authors: Mazouri-Karker Sanae , Lüchinger Robin , Braillard Olivia , Bajwa Nadia , Achab Sophia , Hudelson Patricia , Dominicé Dao Melissa , Junod Perron Noelle 
Published: August 2023

Background
While the use of telemedicine (TLM) increased worldwide during the early phases of the COVID-19 pandemic, little is known about the use and acceptance of TLM post the COVID-19 pandemic.

Objective
This study aims to evaluate patients’ and physicians’ self-reported use, preferences, and acceptability of different types of TLM after the initial phases of the COVID-19 pandemic.

Methods
We conducted a cross-sectional survey among patients and physicians in Geneva, Switzerland, between September 2021 and January 2022. Patients in waiting rooms of both private and public medical centers and emergency services were invited to answer a web-based questionnaire. Physicians working in private and public settings were invited by email to answer a similar questionnaire. The questionnaires assessed participants’ sociodemographics and digital literacy; self-reported use of TLM; as well as preferences and acceptability of TLM for different clinical situations.

Results
A total of 567 patients (309/567, 55% women) and 448 physicians (230/448, 51% women and 225/448, 50% in private practice) responded to the questionnaire. Patients (263/567, 46.5%) and physicians (247/448, 55.2%) generally preferred the phone over other TLM formats and considered it to be acceptable for most medical situations. Email (417/567, 73.6% and 308/448, 68.8%) was acceptable for communicating exam results, and medical certificates (327/567, 67.7% and 297/448, 66.2%) and video (302/567, 53.2% and 288/448, 64.3%) was considered acceptable for psychological support by patients and physicians, respectively. Older age was associated with lower acceptability of video for both patients and physicians (odds ratio [OR] 0.03, 95% CI 0.00-0.33 and OR 0.23, 95% CI 0.08-0.66) while previous use of video was positively associated with video acceptability (OR 3.16, 95% CI 1.84-5.43 and OR 3.34, 95% CI 2.91-5.54). Psychiatrists and hospital physicians were more likely to consider video to be acceptable (OR 10.79, 95% CI 3.96-29.30 and OR 3.97, 95% CI 2.23-7.60).

Conclusions
Despite the development of video, the acceptability of video remains lower than that of the phone for most health issues or patient requests. There is a need to better define for which patients and in which medical situations video can become safe and efficient.
Bioanalytical Method Validation of Metformin Hydrochloride in Human Plasma by HPLC-UV for Preliminary Population-Based Pharmacokinetic Modeling Study
Authors: Adhi Pradana Dimas , Kristin Erna , Nugroho Akhmad Kharis , Nugrahaningsih Dwi Aris Agung , Mustofa Mustofa , Wibowo Ari 
Published: August 2023

This study aims to validate the method for measuring metformin hydrochloride plasma concentrations using High-Performance Liquid Chromatography (HPLC). This research performed chromatography on a 250 mm 4.6 mm 5 µm purosphere® Star RP-18 column at ambient temperature with a UV detector system at 233 nm. The mobile phase components were 70% phosphate buffer (KH2PO4) (10 mM), sodium dodecyl sulfate (0.3 mM), and 30% acetonitrile. It was pumped at an isocratic flow rate of 1.2 mL/min. Metformin HCl and ranitidine HCl (internal standard) were extracted using acetonitrile. The calibration curve was linear (R2 = 0.9998) in the 0.18–6 µg/mL concentration range. The lower limit of quantification (LLOQ) was 0.18 µg/mL. For intraday accuracy and precision, the percent difference and the coefficient of variation were less than 4 and 7%, and for inter-day were lower than 8 and 6%. The recovery average was 100.96%. The short-term plasma stability test was stable at 24 h at ambient temperature, and the long-term stability test was steady for 30 d at −20 °C. It was also stable after three freeze-thaw cycles. The method meets selectivity, sensitivity, linearity, accuracy, precision, recovery, carryover, and stability requirements and can be applied to population-based pharmacokinetic modeling.
Improved Mucoadhesive Properties of Repaglinide-Loaded Nanoparticles: Mathematical Modelling through Machine Learning-Based Approach
Authors: Namazi Nader Ibrahim 
Published: August 2023

This research work aims to develop a modified repaglinide-loaded chitosan-ethyl cellulose nanoparticles (RPG-ECSNPs) as a novel sustained-release dosage form with improved mucoadhesive properties using an emulsification solvent-evaporation technique. The RPG-ECSNPs with different particle sizes were prepared from various polymers containing ethyl cellulose (EC) as the internal phase and chitosan (CS) as the external phase, and the use of surfactants, including Tween 80 and poloxamer 188 as emulsifiers. In vitro drug release, drug loading amount, and entrapment efficiency have been influenced by changes in the concentrations of CS and EC. The mean droplet size and zeta potential of RPG-ECSNPs were 213 ± 8.5 nm and 16.4 ± 2.4 mV, respectively. The optimized formulation's entrapment efficiency was 66 ± 2.3%, and drug loading was 7.9 ± 1.65%. The release profile was significantly higher in PBS (90%) than in diluted hydrochloric acid (30%) during 24 h of the study. The mucoadhesive function of the particles was examined in vitro using part of rat intestines. The highest adhesive % was observed for the chitosan-coated NPs. No adhesive properties were noticed for chitosan-free NPs (P-value > 0.05). This indicated that ECSNPs can be successfully utilized for sustained and controlled drug delivery of RPG through the GIT.
Pengaruh self-efficacy terhadap perilaku komunikasi seksual orang tua-remaja yang dimediasi oleh niat
Authors: Puspitasari Riska , Maimunah Siti , Firdiyanti Retno 
Published: August 2023

Adolescence is a time when individuals begin to explore and experiment with sex. Parents play an important role in directing and providing support to adolescents regarding sexuality so that adolescents do not fall into unwanted things. Integrated Behavior Model (IBM) theory is a theory that suppresses individual behavior change determined by intention. Intention cannot be formed without self-efficacy. The purpose of this study was to determine the effect of self-efficacy on parent-adolescent sexual communication behavior mediated by intention. This research uses a quantitative approach with a correlational research design. The subjects of this study were 315 parents who came from various cities in Indonesia and had teenage children aged 14-17 years. Analysis of the data in this study uses mediation analysis to measure that the intention to be a mediator of self-efficacy on sexual communication behavior. The results showed that self-efficacy had a direct effect on the estimate value -0.037 and indirectly or through the intention on parent-adolescent sexual communication behavior with an estimate value 0.013. It is also hoped that parents can increase the desire to engage in sexual communication with their teenagers.
Keywords: Intentions, self-efficacy, sexual communication, sexual communication behavior
Penerapan Adaptive Neuro Fuzzy Infrence System (ANFIS) dalam Prediksi Produksi Tembakau di Jember
Authors: Matsniya Azimatul , Riski Abduh , Kamsyakawuni Ahmad 
Published: August 2023

Tembakau merupakan salah satu komoditas perkebunan di Indonesia. Kabupaten Jember merupakan penghasil tembakau kualitas dunia terbesar di Jawa Timur. Produksi tembakau di Kabupaten Jember mengalami fluktuasi setiap tahunnya sehingga perlu dilakukan prediksi produksi tembakau dengan menggunakan ANFIS (Adaptive Neuro Fuzzy Inference System). Penelitian ini bertujuan untuk memprediksi produksi tembakau di Kabupaten Jember. Data yang digunakan dalam penelitian ini adalah curah hujan, luas lahan panen tembakau, produktivitas tembakau, dan produksi tembakau di Kabupaten Jember. Jaringan ANFIS yang dibuat terdiri dari tiga variabel input dan satu variabel output. Fungsi keanggotaan yang digunakan adalah generalized bell dan gaussian dengan total fungsi keanggotaan sebesar tiga buah. Jenis output dibagi menjadi dua, yaitu linier dan konstan. Hasil penelitian menunjukkan bahwa model terbaik adalah menggunakan fungsi keanggotaan generalized bell tipe output konstan dengan nilai MAPE pada proses pelatihan dan pengujian berturut-turut adalah 0,00015% dan 0,091%. Hasil prediksi produksi tembakau pada tahun 2021 adalah 199.603,71 kuintal. Variabel yang paling berpengaruh untuk produksi tembakau adalah curah hujan dan produktivitas tembakau.
Analisis Manajemen Bandwidth dan Keamanan Jaringan Menggunakan Metode Hierarchical Token Bucket dan Port Knocking Pada Router Mikrotik
Authors: Ocha Safira Nareza , Wahyudi Eka , Khair Fauza 
Published: August 2023

Penelitian membahas tentang penerapan manajemen bandwidth dan keamanan jaringan menggunakan metode hierarchical token bucket dan port knocking pada router mikrotik. Pada penelitian ini mengambil contoh kasus penerapan yang sudah dilakukan di Perumdam Tirta Satria yang melakukan manajemen bandwidth dengan alokasi bandwidth dari provider sebesar 150Mbps. Serta penerapan kemamanan jaringan menggunakan metode port knocking yang dapat mengatur dan membatasi user / client dalam mengakses server atau koneksi public. Penelitian ini bertujuan untuk mengetahui seberapa efektif penerapan metode hierarchical token bucket dan port knocking pada router mikrotik. Pengujian dilakukan dengan mengukur Quality of service (QoS) menggunakan tools wireshark pada server jaringan setelah diterapkan nya metode tersebut. Dari hasil pengujian QoS dapat diketahui bahwa penerapan metode tersebut berhasil sangat baik dengan nilai throughput 73,059kbps (standart >100kbps), delay 0,007163 ms (standart <1 ms), jitter 0,000833 ms (standart <1 ms) dan packet loss 0% (standart 0%). Serta dalam pengujian scanning port dapat dilihat hasil bahwa port tersebut dalam status filtered yang berarti port tersebut hanya bisa di akses oleh koneksi yang sudah di tertukan di router mikrotik.