bluuebunny/crossref_metadata_2025_split huggingface dataset:
Injectable Intrinsic Photothermal Hydrogel Bioadhesive with On‐Demand Removability for Wound Closure and MRSA‐Infected Wound Healing
Authors: Kang Xinchang , Guan Pengfei , Xiao Cairong , Liu Can , Guan Youjun , Lin Yeying , Tian Yu , Ren Kunyu , Huang Yanting , Fu Rumin , Ning Chengyun , Fan Lei , Tan Guoxin , Zhou Lei 
Published: January 2023

AbstractPhotothermal hydrogel adhesives have yielded promising results for wound closure and infected wound treatment in recent years. However, photothermal hydrogel bioadhesives with on‐demand removability without additional nanomaterials‐based photothermal agents have rarely been reported in the literature. In this work, an injectable intrinsic photothermal hydrogel bioadhesive with an on‐demand removal trait is developed through dynamic cross‐linking of gelatin (Gel), tannic acid (TA) quinone, and borax for closing skin incisions and accelerating methicillin‐resistant Staphylococcus aureus (MRSA) infected wound healing. The TA quinone containing polyphenol and quinone groups with multifunctional adhesiveness and intrinsic photothermal performance confer the hydrogel adhesive with near‐infrared (NIR) responsive antibacterial activity. The cross‐linking of pH‐sensitive boronic ester (polyphenol−B) and Schiff base bonds endow the hydrogel with great self‐healing capacity and on‐demand removability. Moreover, the hydrogel possesses good biocompatibility, injectability, and hemostasis. The in vivo experiment in a rat cutaneous incision model and full‐thickness MRSA‐infected wound model indicate that the smart hydrogel can close wounds efficiently and treat infected ones, demonstrating its superiority in noninvasive treatment of cutaneous incisions and enhancing infected full‐thickness wound healing.
Development and Evaluation of a Low‐Cost LEGO 3D Bioprinter: From Building‐Blocks to Building Blocks of Life
Authors: Moukachar Ahmad , Harvey Katie , Roke Eva , Sloan Katherine , Pool Cameron , Moola Shabbir , Alshukri Ameer , Jarvis Danielle , Crews‐Rees Phoebe , McDermott Grace , Evans Lluan , Li Jin , Thomas Christopher , Coulman Sion , Castell Oliver 
Published: January 2023

AbstractThe development of low‐cost accessible technologies for rapid prototyping of mechanical components has democratised engineering tools for hobbyists and researchers alike. The development of analogous approaches to fabrication of soft‐matter, and biologically compatible materials containing living cells, is anticipated to be similarly enabling across multiple fields of biological research. LEGO toy construction bricks represent low‐cost, precision engineered, and versatile construction materials for rapid prototyping. This study demonstrates construction of a benchtop LEGO 3D bioprinter for additive layer manufacture of a 3D structure containing viable human skin cells within a hydrogel scaffold. 3D bioprinted structures are formed from the deposition of microfluidically generated bio‐ink droplets containing live keratinocyte skin cells, representing components toward an artificial skin model. Fluid flow rates and printer speed, together with bio‐ink gelation rate, determine droplet packing arrangement in the bioprinted structures. The printing of 3D structures containing multiple bio‐inks is demonstrated and live cells are imaged in the resulting bioprints. Fluid delivery can be achieved using LEGO pumps and readily available, or home‐3D‐printed, microfluidic components, therefore avoiding the need for any specialist microfluidic hardware. Build instructions are described to enable easy uptake, modification and improvement by other laboratories, as well provide an accessible platform for learning and education. Affordable, accessible, and easy to use tools for 3D bioprinting are anticipated to open opportunities for a greater number of research labs to work with 3D cell culture and bio‐printed materials, with bioprinting expected to assist in better understanding of disease, contribute to tissue engineering and repair, and enable personalised medicine through the printing of cultured patient cells. The presented approach is not only an easily accessible laboratory tool for bioprinting, but also provides a learning system for mechanical construction, robotics, coding, microfluidics and cell biology, making it a versatile platform for research, education, and science engagement.
Smartphone Authentication of Unclonable Anticounterfeiting Labels based on a Microlens Array atop a Microphosphor‐Doped Layer
Authors: Kumar Vinay , Gota Fabrizio , Neyret Julien , Katumo Ngei , Chauhan Aditya , Dottermusch Stephan , Richards Bryce S. , Howard Ian A. 
Published: January 2023

AbstractA phosphor‐particle‐loaded microlens array on a polymer substrate offers an attractive unclonable anticounterfeiting label design. A random pattern of bright emission points is created due to the random coincidences of light focused by a microlens with an underlying phosphor microparticle. The change of the bright point patter with the angle of the incident light (owing to a shift in the locations of the focal points) makes the labels unclonable. This work examines the authentication of such labels using a single smartphone. The smartphone flashlight provides illumination whereas the camera is used for detection (optical filters prevent capture of scattered source light). A 196‐bit binary string is created from the captured images to identify which lenses in the 14 × 14 array create bright emission points for a given position of the smartphone. The classification of test and reference images as matching or not is achieved with >99% confidence, as is a 1 cm tolerance for the positioning accuracy of the smartphone. Moreover, authentication is possible for different distances between flash and camera provided this is less than 3 cm. In summary, the present work quantifies the good potential of the microlens array microphosphor unclonable label concept for authentication using a smartphone.
Nonplanar 3D Printing of Epoxy Using Freeform Reversible Embedding
Authors: Arun Neeha Dev , Yang Humphrey , Yao Lining , Feinberg Adam W. 
Published: January 2023

AbstractThermally cured thermoset polymers such as epoxies are widely used in industry and manufacturing due to their thermal, chemical, and electrical resistance, and mechanical strength and toughness. However, it can be challenging to 3D print thermally cured thermosets without rheological modification because they tend to flow and not hold their shape when extruded due to cure times of minutes to hours. 3D printing inside a support bath addresses this by allowing the liquid polymer to be held in place until the thermoset is fully cured and expands the structures that can be printed as extrusion is not limited to layer‐by‐layer. Here, the use of Freeform Reversible Embedding (FRE) to 3D print off‐the‐shelf thermoset epoxy into lattice structures using nonplanar extrusion is reported. To do this, the authors investigate how extrusion direction in 3D space impacts epoxy filament morphology and fusion at filament intersections. Furthermore, the advantages of this approach are shown by using nonplanar printing to produce lattice geometries that show ≈ four times greater specific modulus compared with lattice structures printed using other materials and printing techniques.
Self‐Feedback Sensing Properties of Self‐Powered Multi‐Parameter Meteorological Sensor with Omnidirectional Array Structure
Authors: Song Jinsha , Mu Jiliang , Mu Jinbiao , He Huicheng , Duan Zhigang , Zhang Le , Qiao Xiaojun , Geng Wenping , He Jian , Chou Xiujian 
Published: January 2023

AbstractFrequent meteorological disasters pose more and more extensive threats to human life and property. However, the traditional meteorological sensors based on external power supply, for natural disaster monitoring and early warning, are severely limited in remote and unattended areas. Herein, a self‐powered multi‐parameter meteorological sensor (SMPM‐sensor) for various weather monitoring is proposed, which can monitor the weather through the feedback of electrical energy output while collecting natural energy. The designed 360° omnidirectional array structure facilitates efficient collection of all‐weather solar energy and rain energy in different directions and monitoring the light intensity without the influence of solar azimuth. Based on the four‐segmented disc‐shaped structure and the introduced Ecoflex transition layer, the frequency and amplitude of the wind electrical output can be effectively improved. Owing to structure and material optimizations, a good linearity of 0.9746 between the current and the solar illuminance is exhibited, a wide monitoring range of rainfall intensity changes from 0.1 to 11.9 mm min−1, and the linearity between wind speed and voltage frequency can be as high as 0.9986. Therefore, based on excellent sensing performances, good stability, and real‐time characteristic, the fabricated SMPM sensor provides a potential technological strategy for the field of meteorological disaster monitoring.
Reducing the risk of onion bacterial diseases: A review of cultural management strategies
Authors: Belo Tessa , du Toit Lindsey J. , LaHue Gabriel T. 
Published: January 2023

AbstractOnion (Allium cepa L.) bacterial diseases can cause catastrophic crop losses. Chemical and biological control products are not curative and have mixed or limited efficacy at preventing onion bacterial diseases. Cultural management strategies, such as appropriate irrigation and nitrogen (N) management practices, can reduce the risk for bacterial infection and disease progression. This review synthesizes available literature on cultural management strategies to mitigate onion bacterial diseases and identifies knowledge gaps, promising strategies, and limitations. This synthesis revealed that high N fertilizer application rates, the use of overhead irrigation, and late‐season irrigation or rainfall, especially during field curing, can increase bacterial disease pressure. These factors contribute to conducive conditions for bacteria to colonize the foliage and neck of onion plants. Other in‐season strategies, such as reducing the total amount of irrigation or adjusting application rates of nutrients other than N, have not limited losses to bacterial bulb rots while maintaining desired yields. At the end of the growing season, appropriate timing of lifting bulbs (undercutting to sever the roots) and other practices that speed field curing can reduce the risk of bacterial bulb rots. However, it is less clear if topping (removing foliage) before or after curing influences bacterial bulb rots. Conflicting results reported for some cultural management strategies indicate that local conditions, such as climate and soil types, must be considered for optimizing practices to manage onion bacterial diseases. Advancing our scientific understanding and grower awareness of strategies that reduce onion bacterial diseases is a cost‐effective opportunity to avoid losses.
Body composition and nutritional status of school‐aged Haitian children living in urban and peri‐urban areas of Puerto Plata, Dominican Republic
Authors: Arps Shahna 
Published: January 2023

AbstractObjectivesThis study examines body composition and nutritional status of Haitian children and adolescents living in urban and peri‐urban communities in the Dominican Republic to provide estimates of stunting, underweight, overweight, and obesity for this under‐researched population.MethodsAnthropometric measures including height, weight, mid‐upper arm circumference, and skinfold thicknesses (triceps and subscapular) were obtained for Kreyòl‐speaking school‐aged children (n = 105, males = 51, females = 54, ages 4–17). Z‐scores for height, body mass index (BMI), and upper arm muscle area by height were used to classify children's nutritional status. Variation among sex and age groups was assessed.ResultsRelatively low rates of stunting (4.8%) and thinness (2.9%) were identified. The total prevalence of overweight was 5.7% and 2.9% of children were classified as having obesity. Girls had a higher prevalence of overweight/obesity and risk of overweight (16.7%) than boys (3.9%, p = .033).ConclusionsThe prevalence of overweight and obesity (8.6%) suggests that Haitian children in these urban and peri‐urban communities are experiencing the nutrition transition. Interventions should address the development of excess weight, especially among girls, as well as persisting undernutrition and stunting.
Angular Spectra Tunable Random Lasing for High Contrast Imaging
Authors: Shen Huihui , Yuan Hongyu , Bian Yaoxing , Li Junyan , Liu Weinian , Xue Hanyi , Wang Zhaona 
Published: January 2023

AbstractRandom lasers with low spatial coherence have important potential applications in speckle‐free imaging and displaying. Here, an angular spectra (AS) tunable random laser is proposed through directly coupling a microcavity with a commercial optical fiber. The local in‐plane AS distributions of the random lasing can be separately tuned by selectively using coupling filtering, free transmission, and intensity modulation. The obtained random lasing has the characteristics of non‐polarization and ring AS with distribution tunability. The unique properties endow the lasing as a promising illumination source for biological imaging. An excellent image with speckle‐free and high contrast is thus achieved with a maximal contrast improvement factor of 638% relative to that under the common white lighting. The results indicate that the designed AS‐tunable random laser has great application values in the fields of biological imaging, display, integration optics, and optical physics.
Design and synthesis of novel quinazolin‐4(1H)‐one derivatives as potent and selective inhibitors targeting AKR1B1
Authors: Han Zhongfei , Li Jiahui , Xu Zilu , Su Yu , Wang Yihan , Zhuo Lili , Du Jiaming , Zhu Changjin , Hao Xin 
Published: January 2023

AbstractInhibition of aldose reductase (AKR1B1) is a promising option for the treatment of diabetic complications. However, most of the developed small molecule inhibitors lack selectivity or suffer from low bioactivity. To address this limitation, a novel series of quinazolin‐4(1H)‐one derivatives as potent and selective inhibitors of AKR1B1 were designed and synthesized. Aldose reductase inhibitory activities of the novel compounds were characterized by IC50 values ranging from 0.015 to 31.497 μM. Markedly enhanced selectivity of these derivatives was also recorded, which was further supported by docking studies. Of these inhibitors, compound 5g exhibited the highest inhibition activity with selectivity indices reaching 1190.8. The structure–activity relationship highlighted the importance of N1‐acetic acid and N3‐benzyl groups with electron‐withdrawing substituents on the quinazolin‐4(1H)‐one scaffold for the construction of efficient and selective AKR1B1 inhibitors.
Dynamic crosstalk between hematopoietic stem cells and their niche from emergence to aging
Authors: Deng Zhao‐hua , Ma Lan‐yue , Chen Qi , Liu Yang 
Published: January 2023

AbstractThe behavior of somatic stem cells is regulated by their niche. Interaction between hematopoietic stem cells (HSCs) and their niches are a representative model to understand stem cell‐niche interplay. Here, we provide an overview of crosstalk between HSCs and their niches in bone marrow and extramedullary organs following the life journey of HSCs from emergence, development, maturation until aging. We highlight the unique differences of HSC niches in different life stages within various organs focusing on recent literature to propose new speculations and hypotheses.
LncRNA DICER1‐AS1 promotes colorectal cancer progression by activating the MAPK/ERK signaling pathway through sponging miR‐650
Authors: Li Wenfei , Ke Chuanfeng , Yang Cuiyan , Li Jieyao , Chen Qikui , Xia Zhongsheng , Xu Jihao 
Published: January 2023

AbstractBackgroundColorectal cancer (CRC) is a disease with high morbidity and mortality rates globally. Long noncoding RNAs (lncRNAs) play a fundamental role in tumor progression, and increasing attention has been paid to their role in CRC. This study aimed to determine the function of lncRNA DICER1 antisense RNA 1 (DICER1‐AS1) in CRC and confirm its potential regulatory mechanisms in CRC.MethodsThe publicly available dataset was used to assess DICER1‐AS1 function and expression in CRC. RT–qPCR or western blot assays were performed to verify DICER1‐AS1, miR‐650, and mitogen‐activated protein kinase 1 (MAPK1) expression in CRC cells or tissues. To determine the function of DICER1‐AS1, we performed CCK‐8, colony formation, transwell, cell cycle, and in vivo animal assays. Using RNA sequence analysis, luciferase reporter assays, and bioinformatics analysis, the connection between DICER1‐AS1, MAPK1, and miR‐650 was investigated.ResultsDICER1‐AS1 was significantly upregulated in CRC tissue compared to normal colon tissue. High DICER1‐AS1 expression suggested a poor prognosis in CRC patients. Functionally, upregulation of DICER1‐AS1 effectively promoted CRC proliferation, migration, and invasion ex vivo and tumor progression in vivo. Mechanistically, DICER1‐AS1 functions as a competitive endogenous RNA (ceRNA) that sponges miR‐650 to upregulate MAPK1, promotes ERK1/2 phosphorylation, and sequentially activates the MAPK/ERK signaling pathway.ConclusionOur investigations found that upregulation of DICER1‐AS1 activates the MAPK/ERK signaling pathway by sponging miR‐650 to promote CRC progression, revealing a possible clinically significant biomarker and therapeutic target.
Comparison of the sensitivity of different criteria to select lung cancer patients for screening in a cohort of German patients
Authors: Walter Julia , Kauffmann‐Guerrero Diego , Muley Thomas , Reck Martin , Fuge Jan , Günther Andreas , Majeed Raphael W. , Savai Rajkumar , Koch Ina , Dinkel Julien , Schneider Christian , Senghas Karsten , Kobinger Sonja , Manapov Farkhad , Thomas Michael , Kahnert Kathrin , Winter Hauke , Behr Jürgen , Tammemägi Martin , Tufman Amanda 
Published: January 2023

AbstractIntroductionTrials of CT‐based screening for lung cancer have shown a mortality advantage for screening in North America and Europe. Before introducing a nationwide lung cancer screening program in Germany, it is important to assess the criteria used in international trials in the German population.MethodsWe used data from 3623 lung cancer patients from the data warehouse of the German Center for Lung Research (DZL). We compared the sensitivity of the following lung cancer screening criteria overall and stratified by age and histology: the National Lung Screening Trial (NLST), the Danish Lung Cancer Screening Trial (DLCST), the 2013 and 2021 US Preventive Services Task Force (USPSTF), and an adapted version of the Prostate, Lung, Colorectal, and Ovarian no race model (adapted PLCOm2012) with 6‐year risk thresholds of 1.0%/6 year and 1.7%/6 year.ResultsOverall, the adapted PLCOm2012 model (1%/6 years), selected the highest proportion of lung cancer patients for screening (72.4%), followed by the 2021 USPSTF (70.0%), the adapted PLCOm2012 (1.7%/6 year) (57.4%), the 2013 USPTF (57.0%), DLCST criteria (48.7%), and the NLST (48.5%). The adapted PLCOm2012 risk model (1.0%/6 year) had the highest sensitivity for all histological types except for small‐cell and large‐cell carcinomas (non‐significant), whereas the 2021 USPTF selected a higher proportion of patients. The sensitivity levels were higher in males than in females.ConclusionUsing a risk‐based selection score resulted in higher sensitivities compared to criteria using dichotomized age and smoking history. However, gender disparities were apparent in all studied eligibility criteria. In light of increasing lung cancer incidences in women, all selection criteria should be reviewed for ways to close this gender gap, especially when implementing a large‐scale lung cancer screening program.
Sulfonic Acid‐Functionalized (Bio)Materials as Catalysts for Efficient Amide Bond Synthesis
Authors: Pereira Joana R. , Corvo Marta C. , Peixoto Andreia F. , Aguiar‐Ricardo Ana , Marques M. Manuel B. 
Published: January 2023

AbstractSulfonic acid carbon‐(bio)based and natural clays‐based catalysts were prepared and investigated for the first time as heterogeneous catalysts for amide bond synthesis by a Ritter reaction. The different SO3H‐catalysts were screened using benzyl alcohol and acetonitrile as model substrates, and MWCNT‐CSP revealed to be an efficient catalyst, affording the amide in 75 % yield. The practical utility of the catalysts was demonstrated by a diverse range of amides, obtained from alcohols and nitriles, in moderate to good yields. Biomass derived platform alcohols, such as 5‐HMF and furfuryl alcohol, were also tested as potential building blocks for the synthesis of biopolymers. The SO3H‐catalysts revealed to be a highly efficient and environmentally friendly alternative to the conventional acid catalysts commonly used in the Ritter reaction.
Whole‐cell Mediated Carboxylation of 2‐Furoic Acid Towards the Production of Renewable Platform Chemicals and Biomaterials
Authors: Lopez‐Lorenzo Ximena , Asem Heba , Stamm Arne , Subramaniyan Sathiyaraj , Hakkarainen Minna , Syrén Per‐Olof 
Published: January 2023

Abstract2,5‐furandicarboxylic acid (FDCA) has gained great industrial interest as a renewable alternative to terephthalic acid (TPA) in the generation of bioplastics. However, chemical production of FDCA involves harsh reaction conditions not aligned with sustainable manufacturing. Herein, we demonstrate the use of whole‐cell mediated synthesis of FDCA from 2‐furoic acid (FA) as substrate. Our approach moves away from the use of isolated enzymes by supplementing the UbiD−UbiX system in E. coli with the gene of P. thermopropionicum HmfF (PtHmfF) known to generate FDCA. The resulting whole‐cell system allows for production of FDCA under mild conditions by carboxylation of FA. We show how the enzymatically produced FDCA can be used to generate FDCA‐based biopolymers along with a terpene‐based diol monomer by enzymatic polycondensation catalyzed by Candida antarctica lipase B (CALB). This work high‐lights how underutilized hemicellulose‐derived C5 building blocks can be converted into renewable platform chemicals and materials by a simple cell factory in a CO2 sequestration process.
Simulation study of the thermal insulation performance of a vacuum‐insulated tube inside an electrically heated device
Authors: Xu Jian , Li Te , Zhang Hui , Hu Anfu , Teng Ruyu , Xiao Weiqiang , Zhou Guojun , Han Yufeng , Zhan Wangcheng 
Published: January 2023

AbstractTo realize stable heating of a heated cigarette while effectively controlling the outer‐wall temperature of an electric heating‐type appliance, a vacuum‐insulated tube (VIT) is currently widely used for thermal insulation against the heating element. The effects of the critical parameters of the VIT, gases at different pressures, wall thickness, and material on its thermal insulation performance, were simulated using Fluent to provide guidance on the structure and performance optimization of the EHD. When the absolute pressure of gas in the VIT was <0.5 Pa, increasing the degree of vacuum did not improve the thermal insulation performance. The thermal insulation performance of VITs made from different materials (stainless steel, copper, aluminium, brass, and titanium alloy) was closely related to the emissivity and thermal conductivity of the material. Stainless steel yielded better overall thermal insulation owing to its low thermal conductivity and emissivity. Highly emissive materials, such as brass and titanium alloy, contributed to higher heat transfers through the radiation inside the vacuum chamber and external radiation from the VIT, decreasing the thermal insulation performance of the VIT. Stainless steel VITs yielded an improved thermal insulation performance as the wall thickness decreased, but at the cost of decreased mechanical stability. For a wall thickness of 0.05–0.30 mm, stainless steel yielded the best structural stability. VITs with different wall thicknesses were made from stainless steel, copper, and aluminium, and the thermal insulation performance and structural stability of the EHD were optimized.