bluuebunny/crossref_metadata_2025_split huggingface dataset:
ПРОБЛЕМА ОРГАНІЗАЦІЇ ПРОФЕСІЙНО-ТРУДОВОЇ ПІДГОТОВКИ УЧНІВ З ПОРУШЕННЯМИ ІНТЕЛЕКТУАЛЬНОГО РОЗВИТКУ
Authors: Абакумова Ірина 
Published: May 2023

У статті розглядається питання професійно-трудової підготовки учнів в системі освіти з метою забезпечення їхньої соціальної адаптації, дається тлумачення поняття «професійно-трудова компетентність випускника спеціальної школи». Метою статті є висвітлення організації професійно-трудової підготовки учнів з порушеннями інтелекту в психолого–педагогічній літературі. У дослідженні, для досягнення поставленої мети, були використані методи аналізу, систематизації та узагальнення матеріалу. Автором представлено аналіз психолого-педагогічних досліджень вітчизняних науковців з проблем соціально-трудової адаптації випускників спеціальних закладів освіти, які мають інтелектуальні порушення. Названо труднощі працевлаштування і соціалізації цих підлітків та чинники, якими вони обумовлені. Узагальнено доробки вітчизняної спеціальної педагогіки і психології, що сприяли становленню й розвитку професійного-трудового навчання учнів з порушеннями інтелектуального розвитку в Україні: врахування індивідуальних пізнавальних можливостей, особистісних потреб; застосування диференційованого підходу до комплектування класів; формування мотиваційної сфери дітей; створення системи професійно-трудового навчання в закладах освіти. Наведено основні положення нормативно-правової бази, які регулюють організацію професійнотрудового навчання в спеціальній загальноосвітній школі в сучасних умовах. Показано роль і місце вчителя трудового навчання в процесі професійного самовизначення підлітків з порушеннями інтелектуального розвитку. Окреслено проблему удосконалення змісту навчальних програм, розроблення варіативного змісту професійно-трудової підготовки учнів відповідно їхніх психофізичних можливостей та потреб. Наголошується на можливості розв’язання поставленої проблеми в навчальному процесі спеціальної школи шляхом формування в учнів професійно-трудової компетентності як інтегрованого результату педагогічного, психологічного і соціального впливів в системі професійно-трудового навчання. Акцентується увага на врахуванні рівня розвитку пізнавальної, емоційно-вольової та комунікативної діяльності школярів, їхніх інтересів та здібностей, забезпечення корекційно-розвивальної складової професійно-трудового навчання.
Uji Kevalidan Dan Keterbacaan Instrumen Tes HOTS Berbasis 3TMC Tema Menjaga Tekanan Darah Untuk Siswa Kelas VIII
Authors: Azzahra Nadiyah , Sjaifuddin Sjaifuddin , Septi Kurniasih 
Published: May 2023

Konsep IPA bersifat abstrak sehingga memerlukan pembelajaran kontekstual untuk menumbuhkembangkan kognitif siswa. Salah satu upayanya adalah dengan menerapkan pembelajaran dan penilaian yang mengukur tingkat kemampuan secara utuh, seperti penerapan penilaian diagnostik pada tingkat HOTS. Tujuan penelitian ini adalah untuk mengetahui validitas dan keterbacaan instrumen tes HOTS berbasis 3TMC tema menjaga tekanan darah. Penelitian ini mengacu pada model Thiagarajan yang terdiri dari 3 tahapan yaitu: define, design, dan develop. Instrument tes yang dikembangkan dinilai oleh 2 orang dosen ahli materi, 2 orang dosen ahli evaluasi, 3 orang praktisi, dan 30 siswa kelas VIII SMP. Pengumpulan data menggunakan lembar wawancara, lembar validasi, dan angket keterbacaan. Hasil penilaian menunjukkan bahwa 92,1% instrumen tes berada dalam kategori sangat valid sehingga dapat digunakan sebagai alat evaluasi. Selanjutnya produk direvisi dan direduksi hingga memperoleh persentase keterbacaan 86,5% (kategori sangat baik) yang menunjukkan bahwa produk memuat materi yang dapat dipahami, disajikan secara menarik, ditulis dengan bahasa yang mudah dipahami, serta penyajian tabel dan gambar sudah sesuai.
Kata kunci: Instrumen Tes HOTS; 3TMC; Menjaga Tekanan Darah
Connectivity of Targets for Disaster Risk Reduction and Achievement of Sustainable Development Goals - Case Study: Major Flood in DKI Jakarta 2020
Authors: Subiyanto Adi 
Published: May 2023

[Connectivity of Targets for Disaster Risk Reduction and Achievement of Sustainable Development Goals - Case Study: Major Flood in DKI Jakarta 2020]. DKI Jakarta is naturally a flood-prone area, so handling it is not easy to do. Success in handling floods will have a positive impact on development activities, as reflected in low economic losses. The purpose of this study is to review the causes and triggers of major flooding in the DKI Jakarta area in 2020 and seek connectivity between targets in the Sendai Framework for Disaster Risk Reduction (SFDRR) and the Sustainable Development Goals (SDGs). Researchers collect library materials from various sources that are used to analyze research problems, followed by drawing conclusions. The results showed that the causes of flooding in DKI Jakarta were geological, geomorphological, and river morphometric factors, while the La Nina phenomenon triggered major floods in 2020. The 2020 floods resulted in an economic loss of IDR 960 billion from DKI Jakarta's gross domestic product (701.98 trillion), so the proportion is 0.137 percent. In other words, success in reducing the risk of flood disasters can reduce economic losses and has indirectly encouraged the achievement of several other targets in the SDGs.
Keywords: Floods, La Nina, SFDRR, SDGs, DKI Jakarta
Perancangan Aplikasi Absensi berbasis Android menggunakan QR-CODE pada Pemerintah desa Panguragan Lor
Authors: Sohirin Sohirin 
Published: May 2023

Absensi merupakan suatu kegiatan yang sangat penting di berbagai Bidang, Contohnya kegiatan belajar mengajar, Bidang Industri maupun di Instansi Pemerintahan. di kantor desa Panguragan lor saat ini masih menggunakan sistem tulis tangan untuk melakukan rekap data daftar hadir sehingga kurang bergitu efisien. Selain terkesan jadul di era revolusi industri 4.0 seperti sekarang, metode tersebut masih memiliki kelemahan seperti mudah dimanipulasinya oleh perangkat desa, membutuhkan waktu yang lama untuk melakukakn rekapitulasi daftar hadir, ketidak sesuaian antara jam masuk yang telah disesuaikan dengan jadwal, sering terjadinya perilaku titip absen antar perangkat desa. Oleh karena itu, perlu dibuat sebuah sistem aplikasi absensi berbasis Android di Instansi Pemerintahan desa Panguragan Lor. dalam masalah ini, perancangan aplikasi absensi menggunakan metode Quick Response Code (QR Code), serta menggunakan Google spreadsheet sebagai database. Metode yang digunakan dalaman perancangan sistem ini menggunakan metode Waterfall. Sistem ini juga menggunakan NRPD (Nomor registrasi perangkat desa) sebagai Primary Key yang nanti nya di gunakan oleh perangkat desa untuk Login ke dalam aplikasi, sehingga perangkat desa satu dengan yang lainya memiliki user login yang berbeda beda sehingga bisa mengurangi terjadinya perilaku titip absen. Dengan di bangun nya aplikasi absensi ini agar bisa membantu pemerintah desa Panguragan Lor dalam perekapan persensi, agar lebih efisien dan mengurangi kesalahan dalam input data. Serta, untuk mempermudah pemerintah desa Panguragan Lor dalam mengelola data daftar hadir Perangkat desa.
Kata kunci : android, perangkat desa, absensi, aplikasi.
SISTEM INFORMASI TERINTEGRASI UNTUK MANAJEMEN PERSEDIAAN DAN DISTRIBUSI BARANG PDAM KOTA LANGSA
Authors: Akram Rizalul , Marhamah Marhamah , Novianda Novianda 
Published: May 2023

ABSTRAK
Persediaan barang merupakan aset berharga perusahaan yang berperan penting dalam mendukung aktivitas produksi, sehingga di perlukan pengendalian yang optimal. Perusahaan harus mampu mengendalikan persediaan barang agar tidak terlalu besar. PDAM kota langsa merupakan salah satu perusahaan produksi yang bergerak dibidang pengelolaan air yang mempunyai sebuah gudang yang masih mencatat pengambilan barang ATK maupun Teknik kepada supplier secara manual, sehingga pengelolaan barang masih belum terkomputerisasi dengan baik yang mengakibatkan terjadinya perselisihan barang antara pihak gudang PDAM denga setiap kantor unit. Melalui pengendalian persediaan yang optimal, perusahaan dapat meminimalkan barang yang disediakan, tujuan dari penelitian ini adalah untuk mengatur persediaan barang-barang ATK dan teknik yang tersimpan didalam gudang dan digunakan dalam proses pengambilan barang oleh bagian gudang kepada pihak supplier dan pengeluaran barang yang dilakukan oleh kantor unit. Sebelumnya, setiap barang yang dikeluarkan dari kantor pusat PDAM, kantor unit harus membuat kwitansi pengambilan barang terlebih dahulu melihat permasalahan tersebut maka dibuatlah suatu sistem yang mempermudah dalam pengambilan barang. Penelitian ini menggunakan metode integrasi horizontal dimana terdapat dua sistem yang saling terhubung satu dengan lain nya dengan memaparkan bagaimana pengendalian persediaan barang ATK dan teknik
Kata kunci: persediaan barang, pengeluaran barang, pengendalian persediaan
Decision Tree for Predicting the Mortality in Hemodialysis Patient with Diabetes
Authors: Ardi Noper , Lubis Ahmadi Irmansyah , Isnayanti Isnayanti 
Published: May 2023

Hemodialysis patients with diabetes face a significantly higher risk of mortality compared to those without diabetes. Accurate prediction of mortality in this patient population is crucial for guiding clinical decision-making, improving patient outcomes, and optimizing resource allocation. Hemodialysis is a procedure for cleaning the blood from the waste products of the body's metabolism. this is one of modality to treat end stage kidney disease. Diabetes mellitus is a significant contributor to the global burden of chronic kidney disease (CKD), and patients with diabetes undergoing hemodialysis are at a higher risk of mortality compared to those without diabetes. Identifying factors that influence mortality risk in this population can aid in clinical decision-making and improve patient outcomes. Dialysis is performed on patients with kidney failure, both acute kidney failure and chronic kidney failure. This study is aimed to predict the mortality risk of hemodialysis patients with diabetes. The Taiwanese hemodialysis center enrolled a total of 665 hemodialysis patients. The prediction is based on Decision Tree. Compared with K-Nearest Neighbor, linear discriminant, Logistic Regression, and Ensemble, Decission Tree performed better. As for related medical variables like parathyroid surgery, urea reduction ratio, etc., they play a much smaller role in mortality risk factors than diabetes and cardiovascular disease.
Diabetes
Pengaruh Strategi Deferensiasi Produk, Digital Marketing dan Inovasi Produk terhadap Keunggulan Bersaing Motor Honda Scoppy
Authors: Talambanua Edwin , Nasution Zulkarnain , Harahap Aziddin 
Published: May 2023

Penelitian ini dilakukan untuk mengetahui pengaruh strategi deferensiasi produk, digital marketing dan inovasi produk terhadap Keunggulan Bersaing baik secara simultan maupun maupun secara parsial Motor Merek Honda Scoopy. Penelitian ini dapat digunakan sebagai bahan perbandingan dan referensi dalam melakukan penelitian dengan objek ataupun masalah yang sama dimasa yang akan datang dengan menambah variabel-variabel lainnya, penelitian ini menggunakan metode penelitian Kuantitatif menggunakan data yang bersifat angka-angka dianalisis melalui statistik. Jumlah Sampel dalam penelitian ini adalah sebanyak 79 orang pemilik motor Honda Scoopy. Tekhnik pengumpulan data menggunakan kuisioner kepada responden yang dianggap sesuai dengan penelitian yang akan dilakukan. Data dianalisis menggunakan rumus diantaranya : uji validitas dan realibilitas, uji asumsi klasik, uji analisis regresi berganda, uji f test dan uji t test, uji koefisien determinasi dengan bantuan software SPSS 23. Hasil analisis menunjukkan bahwa variabel strategi deferensiasi produk, digital marketing dan inovasi produk berpengaruh signifikan secara simultan dan parsial terhadap Keunggulan Bersaing Motor merek Honda Scoopy. Variabel strategi deferensiasi produk, digital marketing dan inovasi produk memiliki koefisien regresi positif (+) yang menunjukkan suatu hubungan searah, dengan kata lain, strategi deferensiasi produk, digital marketing dan inovasi produk akan meningkatkan keunggulan Bersaing Motor Merek Honda Scoopy
Uji Bakteri Total Coliform dan Escherichia coli Pada Sumber Mata Air Ubalan Desa Maguan Kecamatan Ngajum Kabupaten Malang
Authors: Aniansyah Octavia Shahilla , Syauqi Ahmad , Laili Saimul 
Published: May 2023

Water is a very important human need and no life can exist without air. Human needs are generally obtained from various sources, both from groundwater, surface water and rainwater. Ubalan is a hamlet located in Ngajum District, Malang Regency. The location is under the foot of Mount Kawi - Malang which has a natural spring and is generally channeled by the surrounding community to fill artificial ponds and also used by the community to meet their daily needs. The use of spring sources is generally very diverse, including for drinking water, fisheries, conservation and as a tourist attraction. Water indicators such as total coliform bacteria and Escherichia coli. Regarding this statement, it is necessary to carry out a microbiological test to test for total coliform and Escherichia coli bacteria at the Ubalan spring, Maguan Village, Ngajum District, Malang Regency, which is a tourist attraction location that is never empty of visitors. The research method used is survey method and descriptive laboratory analysis. To take samples of air sources carried out randomly.
The test results for Total Coliform and Escherichia coli bacteria in West Sumatra Mata Air Ubalan, Maguan Village, Ngajum District, Malang Regency, showed that the MPN results index was at station 3 (0.273) station 2 (0.188) and the lowest was at station 1 (0.138). The analysis is related to the level of the presence of total coliform and E. coli bacteria with pollutant source factors that are thought to come from human activities around the source, community behavior and the distance factor between air sources and exhaust locations. Correlation of research results obtained by the presence of total coliform bacteria and Escherichia coli in the air source with the relationship of factors between the supporting bacteria showed (p value = 0.188) which means it did not have a significant effect.
Evaluating the Effect of Jointly Administering Synthetic Graft and Ankaferd Blood Stopper for Bone Recovery in Created Bone Deformities in Diabetic Rats
Authors: TANIK Abdulsamet , DOGRU Arzum Güler , GÜL Mehmet 
Published: May 2023

Objective: In the present paper, it was purposed to examine the late impacts of bone tissue recoveries in combination with synthetic grafts and Ankaferd Blood Stopper (ABS), which are effective in bone wound healing in diabetic rats.
Methods: A total of 64 Wistar albino male rats with diabetes were studied. A bone deformity was generated in the calvarium of diabetic rats. These diabetic rats are divided into 4 different groups. Only saline was applied to the bone defect in group 1, Beta-tricalcium phosphate (β-TCP) graft was administered to Group 2, ABS solution to Group 3, (β-TCP+ABS) were administered to group 4. Eight rats from each group were sacrificed on the 28th day and another 8 rats on the 56th day. Immunohistochemical, histopathological, and Dual Energy X-ray Absorptiometry (DEXA) analyzes of the obtained samples were made.
Results: In histopathological measurements, osteoblastic activity and bone regeneration were considerably higher in the group treated with group 2 and group 4 when compared to the control group on the 28th and 56th day (p˂ .05). Western blotting findings showed that the osteopontin (OP) and osteonectin (ON) expression at 28th day increased dramatically in the treated with group 4. DEXA analyzes revealed that BMC values in groups treated with group 2, group 3 and group 4 on 28th day were considerably higher than the control group (p˂ .05).
Conclusion: We can believe and conclude that ABS in combination with a β-TCP bone graft will produce more successful outcomes on wound
healing and formation of new bone in diabetic rats.
Relationship Between Staging and Grading of Periodontitis and Periimplantitis: A Retrospective Study
Authors: ÖZTÜRK ÖZENER Hafize 
Published: May 2023

Objective: The purpose of this retrospective study was to determine the relationship between peri-implantitis and stage/grade of periodontitis.
Methods: Records of 171 periodontitis patients with 318 dental implants were screened. Classification of diagnosed patients with periodontitis were done by both stage (1, 2, 3 and 4) and grade (A, B and C). Peri-implant health status was evaluated as no peri-implantitis or with peri-implantitis. Marginal bone loss severity of implants diagnosed with peri-implantitis, prosthesis type (single, bridge), location of dental implants (maxilla, mandibula, anterior and posterior), smoking (yes/no) and diabetes history (yes/no) of the patients were also evaluated. Analysis was done at implant level.
Results: A total of 203 (63.8%) dental implants were diagnosed with peri-implantitis. There were statistical differences in the stage and grade of periodontitis between implants diagnosed with no peri-implantitis and peri-implantitis (p
The opinions of postgraduate nursing students about evidence-based practice: A qualitative study
Authors: YURT Seher , KOLAÇ Nurcan , ŞEN Esra 
Published: May 2023

Objective: This study was conducted for the purpose of exploring the opinions and experiences of postgraduate nursing students regarding evidence-based practice and its use in the clinical setting in Turkey.
Methods: A qualitative study design was employed. Data in this research study were collected through Semi-structured questions were asked face-to-face in focus group discussions.
Results: The findings of the study set forth the individual and organizational barriers that faced postgraduate nursing students in their efforts
to implement evidence-based practices. The main themes of the study were highlighted as: perceptions regarding evidence-based practice, the impact on the group cared for, challenges faced in the implementation, institutional support in applying practices. Subthemes were data verification, useful and reliable application, difficulties in communicating with colleagues, traditional views, troubles with team collaboration, the indifference of young colleagues, insufficient resources, and the need for a mentor in the workplace.
Conclusion: The students in their undergraduate programs, and elective courses on EBP should be added to the curriculum. In order to eliminate organizational barriers, institutions should establish EBP committee and mentoring system.
Combined immunodeficiency caused by pathogenic variants in the ZAP70 C-terminal SH2 domain
Authors: Mongellaz Cédric , Vicente Rita , Noroski Lenora M. , Noraz Nelly , Courgnaud Valérie , Chinen Javier , Faria Emilia , Zimmermann Valérie S. , Taylor Naomi 
Published: May 2023

IntroductionZAP-70, a protein tyrosine kinase recruited to the T cell receptor (TCR), initiates a TCR signaling cascade upon antigen stimulation. Mutations in the ZAP70 gene cause a combined immunodeficiency characterized by low or absent CD8+ T cells and nonfunctional CD4+ T cells. Most deleterious missense ZAP70 mutations in patients are located in the kinase domain but the impact of mutations in the SH2 domains, regulating ZAP-70 recruitment to the TCR, are not well understood.MethodsGenetic analyses were performed on four patients with CD8 lymphopenia and a high resolution melting screening for ZAP70 mutations was developed. The impact of SH2 domain mutations was evaluated by biochemical and functional analyses as well as by protein modeling.Results and discussionGenetic characterization of an infant who presented with pneumocystis pneumonia, mycobacterial infection, and an absence of CD8 T cells revealed a novel homozygous mutation in the C-terminal SH2 domain (SH2-C) of the ZAP70 gene (c.C343T, p.R170C). A distantly related second patient was found to be compound heterozygous for the R170C variant and a 13bp deletion in the ZAP70 kinase domain. While the R170C mutant was highly expressed, there was an absence of TCR-induced proliferation, associated with significantly attenuated TCR-induced ZAP-70 phosphorylation and a lack of binding of ZAP-70 to TCR-ζ. Moreover, a homozygous ZAP-70 R192W variant was identified in 2 siblings with combined immunodeficiency and CD8 lymphopenia, confirming the pathogenicity of this mutation. Structural modeling of this region revealed the critical nature of the arginines at positions 170 and 192, in concert with R190, forming a binding pocket for the phosphorylated TCR-ζ chain. Deleterious mutations in the SH2-C domain result in attenuated ZAP-70 function and clinical manifestations of immunodeficiency.
A new prognostic model including immune biomarkers, genomic proliferation tumor markers (AURKA and MYBL2) and clinical-pathological features optimizes prognosis in neoadjuvant breast cancer patients
Authors: García-Torralba Esmeralda , Navarro Manzano Esther , Luengo-Gil Gines , De la Morena Barrio Pilar , Chaves Benito Asunción , Pérez-Ramos Miguel , Álvarez-Abril Beatriz , Ivars Rubio Alejandra , García-Garre Elisa , Ayala de la Peña Francisco , García-Martínez Elena 
Published: May 2023

BackgroundUp to 30% of breast cancer (BC) patients treated with neoadjuvant chemotherapy (NCT) will relapse. Our objective was to analyze the predictive capacity of several markers associated with immune response and cell proliferation combined with clinical parameters.MethodsThis was a single-center, retrospective cohort study of BC patients treated with NCT (2001-2010), in whom pretreatment biomarkers were analyzed: neutrophil-to-lymphocyte ratio (NLR) in peripheral blood, CD3+ tumor-infiltrating lymphocytes (TILs), and gene expression of AURKA, MYBL2 and MKI67 using qRT-PCR.ResultsA total of 121 patients were included. Median followup was 12 years. In a univariate analysis, NLR, TILs, AURKA, and MYBL2 showed prognostic value for overall survival. In multivariate analyses, including hormone receptor, HER2 status, and response to NCT, NLR (HR 1.23, 95% CI 1.01-1.75), TILs (HR 0.84, 95% CI 0.73-0.93), AURKA (HR 1.05, 95% CI 1.00-1.11) and MYBL2 (HR 1.19, 95% CI 1.05-1.35) remained as independent predictor variables.ConclusionConsecutive addition of these biomarkers to a regression model progressively increased its discriminatory capacity for survival. Should independent cohort studies validate these findings, management of early BC patients may well be changed.
MASALAH MENTAL EMOSIONAL REMAJA SELAMA PEMBELAJARAN JARAK JAUH PADA MASA PANDEMI COVID-19
Authors: Kurniawati Indah , Sinta Ai 
Published: May 2023

Pandemik Covid-19 yang merupakan ancaman global membuat pemerintah mengeluarkan kebijakan di segala bidang, salah satunya dalam bidang Pendidikan dengan memutuskan pembelajaran dari rumah (Learning from home). Proses pembelajaran jarak jauh memiliki beberapa dampak seperti ketidaksiapan siswa, kurangnya interaksi dengan teman, penugasan dan pembelajaran yang singkat membuat siswa rentan mengalami masalah mental emosional. Penelitian ini bertujuan untuk mengetahui gambaran status mental emosional pada remaja selama menjalankan proses pembelajaran jarak jauh pada masa pandemic Covid-19.
Penelitian ini menggunakan pendekatan kuantitatif dengan desain cross sectional. Sampel pada penelitian ini sebanyak 240 responden dengan teknik sampling yang digunakan adalah simple random sampling.
Hasil analisis data penelitian didapatkan sebanyak 60% responden memiliki resiko masalah mental emosional, dengan usia 16 tahun paling tinggi mengalami resiko masalah mental emosional sebesar 57,6% dan jenis kelamin perempuan paling banyak yang beresiko mengalami mental emosional sebanyak 68,5%.
Hasil penelitian ini menunjukkan bahwa Sebagian besar remaja mengalami resiko terjadinya masalah mental emosional dengan pembelajaran jarak jauh selama masa pandemic Covid-19.
Diperlukan adanya peran orang tua dalam memberikan dukungan keluarga pada remaja selama menjalankan proses pembelajaran jarak jauh.