bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Model Pembelajaran Kooperatif Tipe Student Teams Achievement Division (STAD) terhadap Kemampuan Berpikir Analitis Peserta Didik SMAN 1 Jakarta
Authors: Setiawan Aan , Salsabila Ellis , Meidianingsih Qorry 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran kooperatif tipe Student Teams Achievement Division (STAD) terhadap kemampuan berpikir analitis peserta didik. Metode yang digunakan pada penelitian ini adalah penelitian eksperimen semu dengan post-test only control group design. Teknik pengambilan sampel menggunakan teknik purposive sampling dan cluster random sampling. Sampel penelitian yaitu peserta didik kelas XI IPS 1 dan XI IPS 2 di SMA Negeri 1 Jakarta. Kemampuan berpikir analitis peserta didik diukur menggunakan instrumen penelitian yaitu empat soal uraian pada pokok bahasan program linear yang telah valid dan reliabel. Hasil pengujian hipotesis menggunakan uji-t dengan taraf signifikansi serta derajat kebebasan (dk) = 65, diperoleh bahwa statistik uji t = 3,310 > 1,669, sehingga ditolak yang berarti bahwa rata-rata kemampuan berpikir analitis peserta didik yang menerapkan model pembelajaran kooperatif tipe STAD lebih tinggi dibandingkan peserta didik yang menerapkan model pembelajaran konvensional. Kemudian diperoleh nilai Cohen’s d sebesar dengan persentase besar pengaruhnya sebesar 79% yang termasuk ke dalam kategori large (besar). Berdasarkan hasil perhitungan, dapat disimpulkan terdapat pengaruh yang signifikan dari penerapan model pembelajaran kooperatif tipe Student Teams Achievement Division (STAD) terhadap kemampuan berpikir analitis peserta didik SMAN 1 Jakarta.
An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of Amyotrophic Lateral Sclerosis
Authors: Bryson Barney , Kourgiantaki Alexandra , Jiang Dai , Demosthenous Andreas , Greensmith Linda 
Published: March 2023

Abstract

Breakdown of neuromuscular junctions (NMJs) is an early pathological hallmark of amyotrophic lateral sclerosis (ALS) that blocks neuromuscular transmission, leading to muscle weakness, paralysis and, ultimately, premature death. Currently, no therapies exist that can prevent progressive motor neuron degeneration, muscle denervation or paralysis in ALS. Here, we report important advances in the development of an optogenetic, neural replacement strategy that can effectively restore innervation of severely affected skeletal muscles in the aggressive SOD1G93A mouse model of ALS, thus providing an interface to selectively control the function of targeted muscles using optical stimulation. We also identify a specific approach to confer complete survival of allogeneic replacement motor neurons. Furthermore, we demonstrate that an optical stimulation training paradigm can prevent atrophy of reinnervated muscle fibers and results in a 10-fold increase in optically-evoked contractile force. Together, these advances pave the way for an assistive therapy that could benefit all ALS patients.
Aberrant plasma exosomal derived ceRNA networks as diagnosis biomarkers for adolescent major depressive disorder and its potential prediction for antidepressant
Authors: Xu Yifan , Du Xinzhe , Zhang Rong , Huang Yangxi , Gao Yao , Wen Yujiao , Qiao Dan , Sun Ning , Liu Zhifen 
Published: March 2023

Abstract

Background:Major depressive disorder (MDD) in adolescence seriously endangers their mental and physical health and is associated with poor social and scholastic function. However, the diagnosis biomarkers for adolescent with MDD remain unclear.Methods：A total of 114 adolescent subjects were enrolled in this study, the comprehensive clinical and cognitive assessments were performed. Differential expressions of lncRNAs and mRNAs of plasma exosomes were screened by microarray assay. Two sets of ceRNA (lncRNAs-miRNAs-mRNAs) networks had been generated and candidate genes had been screened by bioinformatic analysis, and candidate genes were validated in cohort using qRT-PCR.Results：A total of 3752 differentially expressed lncRNAs and 1789 differentially expressed mRNAs were identified. AC156455.1, miR-126-5p, AAK1 and CCDC18AS1, miR-6835-5p, CCND2 were picked from each network as candidate genes. We found that the six candidate genes were differential expression between MDD patients and healthy controls, or before and after antidepressant treatment of MDD group. The expression levels of AAK1, CCDC18AS1 and miR6835 varied in efficacy after 8-week sertraline treatment. We also found that the expression of CCDC18AS1, miR-6835-5p, CCND2 (in the same network) at baseline could predicted antidepressant efficacy, which may be mediated through reducing suicidal ideation and improving cognitive function.Conclusion:Our study identified and validated the plasma exosome-derived ceRNA networks altered in adolescent with MDD, our findings provided potential diagnosis and therapeutic biomarkers for adolescent with MDD.
Economic evaluation of submerged anaerobic hybrid membrane bioreactor operating at mesophilic temperature
Authors: Burman Isha , Sinha Alok 
Published: March 2023

Abstract

A laboratory-scale mesophilic submerged anaerobic hybrid membrane bioreactor (AnHMBR) was operated for 270 days for treatment of high strength synthetic wastewater at different HRTs (3d, 2d, 1d & 0.5 d). COD removal efficiency of 92% was obtained with methane yield rate of 0.18 LCH4/gCODremoval at 1 d HRT. The results of lab scale reactor at 1 d HRT were utilized for up scaling and cost analysis. Cost analysis of the full-scale AnHMBR system showed that tank cost and heating cost accounted for the largest fraction of total life cycle cost. The heating cost can be compensated by gas recovery and heating of influent by permeate. Sensitivity analysis revealed that interest rates, influent flow and membrane flux were the most crucial parameters which affected the total cost of An-HMBR.
The safety of SGLT-2 inhibitors in diabetic patients submitted to elective percutaneous coronary intervention regarding kidney function: SAFE-PCI pilot study
Authors: Feitosa Mateus Paiva Marques , Lima Eduardo Gomes , Abizaid Alexandre Antônio Cunha , Mehran Roxana , Lopes Neuza Helena Moreira , Ramos Thiago de Assis Fischer , Kajita Alexandre Hideo , Filho Roberto Kalil , Junior Carlos Vicente Serrano 
Published: March 2023

Abstract
Background: Percutaneous coronary intervention (PCI) is one of the most performed well-succeeded therapeutic procedures worldwide, reducing symptoms and improving quality of life. Lidocaine associated with gelatinase neutrophilic acid (NGAL) is a biomarker of acute kidney injury (AKI) produced early after an ischemic renal insult. Osmotic diuresis and the vasoconstriction of the afferent arteriole promoted by SGLT2i generate a concern regarding the possibility of dehydration and consequent AKI. There is no consensus on the maintenance or discontinuation of SGTL2i in patients who will undergo PCI. This study aimed to evaluate the safety of SLGT2i in diabetic patients submitted to elective PCI regarding kidney function
Methods: SAFE-PCI trial is a single-center, prospective, open-label, randomized (1:1) pilot study with 42 randomized patients and a follow-up of 30 days. The SGLT2i empagliflozin 25mg daily was initiated at least 15 days before PCI in the intervention group and maintained until the end of the follow-up period. Serum NGAL was collected 6 hours after PCI and creatinine before PCI, 24 hours, and 48 hours after the procedure. As per protocol, both groups received optimal medical treatment and standard protocol of nephroprotection.
Results: A total of 42 patients were randomized (22 patients in the iSGLT-2 group and 20 patients in the control group). There was no difference between-group baseline data. The primary outcome (NGAL and creatinine values post PCI) did not differ in both groups: the mean NGAL value was 199 ng/dL in the empagliflozin group and 150 ng/dL in the control group (p = 0.249). Although there was an initial increase in creatinine in the SGLT-2i group compared to the control group between baseline creatinine and pre-PCI and 24 hours post-PCI creatinine, no difference was detected in creatinine 48 hours post-PCI (p = 0.065). The incidence of CI-AKI, determined by KDIGO criteria, in the iSGLT2-group was 13,6% and 10% in the control group without statistical difference.
Conclusion: The present study showed that the use of SGLT2i (empagliflozin) is safe regarding kidney function during elective PCI in patients with T2D when compared with no use of SGLT2i.
Trial registration: Our clinical study is registered on ClinicalTrials.gov with the following number: NCT05037695.
The Ferroelectric-Gate Fin Microwave Acoustic Signal Processor
Authors: Hakim Faysal , Rudawski Nicholas , Tharpe Troy , Tabrizian Roozbeh 
Published: March 2023

Abstract
Wireless communication through dynamic spectrum allocation over microwave bands, essential to accommodate exponentially growing data traffic, requires massive array of radio-frequency (RF) filters for adaptive signal shaping at arbitrary frequencies. However, conventional RF filters based on planar acoustic resonators are incapable to realize such massive integrated arrays, due to their large footprint and limited on-chip frequency scalability. Here, we present a signal processor enabled by integration of three-dimensional ferroelectric-gate fin (FGF) nano-acoustic resonators with extreme frequency tailorability and large-scale integrability. FGFs are created by growing atomic-layered ferroelectric hafnia-zirconia transducers on silicon nano-fins, operate in bulk acoustic modes with lithographically scalable frequency over 3-28 GHz, and provide record-high frequency – quality factor – electromechanical coupling product (f×Q×kt2) of 19.4×1010 (at ~11GHz). A monolithic filter-array covering 9-12 GHz is also demonstrated by on-chip electrical coupling of FGFs. This demonstration highlights the potential of FGF resonators to realize chip-scale adaptive processors extendable to millimeter-wave frequencies.
Lyme disease with reversible splenial lesion syndrome: a case report
Authors: Peng Xiaoxue , Chen Wei , Yu Juan , Jiang ZiYang , Tang E , Liu Qing 
Published: March 2023

Abstract
Purpose: Reversible splenial lesion syndrome (RESLES) is a syndrome involving the splenium of the corpus callosum of various causes (mainly including infection, metabolic disorder and seizure) that is diagnosed via imaging. Notably, the RESLES in Lyme disease is particularly rare. Here, we report a case of Lyme disease with RESLES admitted in Meizhou People's Hospital to raise awareness about the disease.
Methods: A male patient having Lyme disease with RESLES was reported, and his clinical presentations, diagnosis, imaging findings and treatment were analyzed.
Results: Lyme disease with RESLES presented with headache and fever as the main clinical presentations, accompanying rashes at the elbow joint. On imaging, cytotoxic edema in the splenium of the corpus callosum was displayed without enhancement. In addition, the serum anti-borrelia burgdorferi antibody IgM was positive. The lesion finally completely disappeared after treatment.
Conclusion: Lyme disease with RESLES is rare, and patients with this disease usually have a history of tick bite. In this patient population, there is a need for careful interrogation of previous histories (e.g., epidemiology, exposure to an infected area and tick bite) and occurrence of rashes, which can help for early diagnosis and targeted treatment to improve patient prognosis.
Socio-cultural beliefs and perceptions that influence diagnosis and treatment of breast cancer among women in Ghana: evidence from a scoping review
Authors: Afaya Agani , Anaba Emmanuel Anongeba , Bam Victoria , Afaya Richard Adongo , Yahaya Rufai-Ahmed , Seidu Abdul Aziz , Ahinkorah Bright Opoku 
Published: March 2023

Abstract

Background Breast cancer is currently the most diagnosed cancer in Ghana and the leading cause of cancer mortality among women. Little published empirical evidence exists on cultural beliefs and perceptions about breast cancer diagnosis and treatment in Ghana. This scoping review sought to map evidence on the sociocultural beliefs and perceptions that influence the diagnosis and treatment of breast cancer among women. Methods This review was conducted following the methodological guideline of JBI and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. The literature search was conducted in PubMed, CINAHL via EBSCOhost, PsycINFO, Web of Science, and Embase. Studies that were conducted on cultural, religious, and spiritual beliefs were included. The included studies were screened by title, abstract, and full text by three reviewers. Data was charted and results were represented in a narrative synthesis form. Results This review included 15 studies. Three categories were identified after the synthesis of the charted data. The categories included: cultural, religious, and spiritual beliefs and misconceptions about breast cancer. The cultural beliefs included ancestral punishment and curses from the gods for wrongdoing leading to breast cancer. Spiritual beliefs about breast cancer were attributed to spiritual or supernatural forces. People had the religious belief that breast cancer was a test from God and resulted in prayers for healing. Conclusion This study adduces evidence of the sociocultural beliefs that impact on untimely diagnosis and treatment of breast cancer among women in Ghana. Taking into consideration the diverse cultural and traditional beliefs about breast cancer diagnosis and treatment, there is a compelling need for nationwide public education on breast cancer to clarify the myths and misconceptions about the disease. We recommend that sociocultural factors influencing breast cancer diagnosis and treatment be incorporated into breast cancer awareness programs, education, and intervention programs in Ghana.
The protein-energy malnutrition is associated with the prevalence and mortality of periodontitis: a dose-response association study
Authors: Zhang Yonghuan , Liu Yanqing , Li Weiqi , Xue Xiaomeng , Pan Yaping , Li Chen , Lin Li 
Published: March 2023

Abstract
Objective: This study aimed to explore the association between protein-energy malnutrition (PEM) and the prevalence and mortality rate of geriatric periodontitis.
Materials and Methods: Participants were recruited from the National Health and Nutrition Examination Surveys (NHANES) between the 1999-2004 and 2009-2014 cycles. Geriatric nutritional risk index (GNRI) as the measurement of PEM and periodontitis was defined according to periodontal examination. Periodontal examination and GNRI data were collected for participants aged ≥65 years. Multifactorial logistic regression was performed to assess the association between GNRI and periodontitis. Cox regression was used to assess the association between GNRI and mortality in patients with periodontitis. Restricted cubic spline (RCS) was used to explore the dose-response association.
Results: Overall, 4442 participants were enrolled. Logistic regression showed that GNRI was significantly associated with periodontitis (OR, 0.981; 95%CI, 0.967–0.995, P=0.009), and RCS showed a significantly increased risk of periodontitis when GNRI was <114.99. Cox regression analysis indicated that GNRI was associated with mortality in patients with periodontitis (HR, 0.979; 95%CI, 0.971–0.986, P<0.001), and RCS showed a significantly increased risk of mortality when GNRI was <114.28.
Conclusion: This study found a significant association between PEM and the risk of periodontitis and periodontitis patients’mortality, and this association was more pronounced among those aged 80 years and older.
Clinical Relevance: PEM is associated with periodontitis and may increase the risk of periodontitis participants’ mortality. More attention demanded to the nutritional intake of protein and energy in geriatric populations, especially those with periodontitis.
Effects of Acetylation, Acid-thinning and Oxidation on Chrysophyllum albidum (African Star Apple) Kernel Native Starch
Authors: Oderinde Abdulazeez Adewale , Ibikunle Adeola Ahmed , Bakre Lateef Gbenga , Babarinde Najeem Abiola 
Published: March 2023

Abstract

Starch is a biological macromolecule with myriad of industrial uses. The growing need for starch and native starch deficiencies, have necessitated researches into under-exploited starch sources and modifications, respectively.Chrysophyllum albidum(African star apple, ASA) seed is a waste consisting of 63.94% carbohydrate in its kernel. Its starch content can be fully utilised, industrially, if it is in a suitable form and its properties understood. That necessitated the isolation of ASA kernel starch, its modification and properties assessment. Acetylation, acid-thinning and oxidation were performed on the native African star apple kernel starch, NACA, to produce the acetylated, ACCA, acid-thinned, ATCA, and oxidised, OXCA, African star apple starches, respectively. The physicochemical properties of the native and modified starches were investigated with established methods. The yield of starch was 43.76%. The acetylated and oxidised starches had low degrees of substitution. FT-IR results confirmed the introduction of carbonyl functionality into the acetylated and oxidised starches. Starch morphology revealed smooth, small rounded and truncated ellipsoid granules with diameter ranges of 7–20 µm. Swelling power of modified starches improved, except for the acid-thinned, and increased with temperature. Acetylated and oxidised starches had significantly (p < 0.05) higher water and oil absorption capacities, respectively. Acid-thinning significantly improved starch pasting properties and reduced retrogradation tendency. Modification improved the gelatinisation transition temperature of native starch. It was concluded that modification increased the industrial raw material potentials of African star apple kernel starch.
Interdecadal variation of tropical cyclone genesis longitudes over the western North Pacific
Authors: Choi JaeWon , Seo Kyong-Hwan 
Published: March 2023

Abstract
The genesis longitudes of the tropical cyclone (TC) for the months of June–October exhibit the gradual westward shift since 1998 and the present study investigates the possible mechanisms. The period of 1998–2020 is characterized by the large anomalous anticyclonic circulation over the western North Pacific (WNP) and an anomalous cyclonic circulation in East Asia. Owing to this huge anomalous anticyclonic circulation, TCs could not develop over the eastern part of the WNP. In addition, the equatorial western Pacific shows a warm anomaly, while the equatorial eastern Pacific presents a cold anomaly; this negative phase of the Pacific Decadal Oscillation (PDO) demonstrates the strengthening of the Walker circulation, which causes greater prevalence of TCs to the western seas of the WNP.
Leukoencephalomacia due to ischemic vascular accident in a Tremarctos ornatus (Spectacled bear)
Authors: Echenique Joanna V.Z. , Piva Manoela M. , Gris Anderson H. , Perosa Fernanda F. , Ribeiro Paula R. , Silva Emanoelly M. S. , Hohendorff Raquel V. , Gomes Caroline W.C. , Sonne Luciana 
Published: March 2023

Abstract

Tremactor ornatus (Spectacled bear) are the only ursids natives of South America and are present in many Zoo collections. Neurologic diseases are not common in this species and brain injuries are linked mainly to viral diseases; however ischemic brain events are not commonly reported. The aim of this paper is to describe the clinical, gross, microscopic, and immunolabeling findings of leukoencephalomacia due to an ischemic vascular accident in a Tremactor ornatus. A captive spectacled bear presented left-sided non-ambulatory hemiparesis, and left-sided hemineglect, but without mentation impair. The animal died spontaneously. Gross findings included asymmetric bilateral friable dusky discoloration areas of malacia, sharply defined in the white matter of the forebrain right hemisphere. Lesions were observed in right parietal and temporal cortex, extending to the thalamus, striate body, and medullary body. Histologically, there was a non-hemorrhagic leukoencephalomacia, with accentuated myelin rarefaction and astrocytes proliferation embedded with Gitter cell infiltrate. Moreover, Luxol Fast Blue highlighted extensive severe myelin loss. The diagnosis was established through the clinical history along with extensive ischemic right hemisphere leukoencephalomacia. Immunohistochemistry was primordial to access repair and inflammatory lesions. To the best authors' knowledge, this is the first report of leukoencephalomacia due to ischemic vascular accident in a Tremarctos ornatus.
Coping Strategies and self-esteem mediate Covid-19 stress and mental health among nurses in the Gaza Strip
Authors: El-Khodary Basel , Diab Marwan , Shubier Tawfeeq , Al-Khatib Abdullah , Veronese Guido 
Published: March 2023

Abstract
The current study aimed to explore the mediating role of coping strategies and self-esteem between Covid-19 stress and mental health among nurses in the Gaza Strip during the Covid-19 outbreak. The sample consisted of 279 participants {141 (49.6%) females and 138 (48.6%) males}. COVID Stress Scales, Rosenberg Self-Esteem Scale, the Ways of Coping Questionnaire and Depression Anxiety Stress Scale were applied. The results showed that female nurses reported more fear of Covid-19 dangerousness and anxiety compared with males. The results also showed that there is a significant positive correlation between fear of the dangerousness of covid and fear of being infected by others, fear of being infected by things, self-esteem, problem-focused coping, anxiety, depression. Moreover, there is a significant positive correlation between fear of being infected by others and fear of being infected by things, self-esteem, problem-focused coping, emotion-focused coping, and anxiety. There is a significant positive correlation between fear of infected by things and emotion-focused coping, and anxiety, depression. Similarly, there is a significant positive correlation between self-esteem and problem-focused coping. Likewise, there is a significant positive correlation between emotion-focused coping and anxiety and depression. Finally, there is a significant positive correlation between anxiety and depression. Supervision and training should focus on improving nurses' emotional intelligence, problem-solving capabilities, and self-esteem to protect health providers from psychological burdens.
Identification of unauthorized electricity based on the consumption data of subscribers with the help of artificial intelligence
Authors: Kojuri Abolghasem Darzi , Sayed Biju Theruvil , Espinosa-Cristia Juan Felipe , Alghamdi Mohammed. I. , Huamán-Romaní Yersi-Luis , Cahuana-Lipa Rocío , Hammid Ali Thaeer , Machaca-Mamani Julio-César 
Published: March 2023

Abstract
One of the most important challenges in electricity distribution companies is the use of unauthorized electricity or electricity theft, which is an important factor in reducing the income of electricity distribution companies. The number of subscribers as well as the large amount of data related to their consumption is increasing rapidly, and the traditional methods to detect suspicious subscribers are difficult, expensive and in some cases almost impossible. In this article, we will deal with five classification models including decision tree, support vector machine, Bayesian rule, neural network and k-nearest neighbor classification on 300 real data of electricity affairs in order to detect subscribers with unauthorized electricity, the results of which according to the real input data in the diagnosis The best smart model will be very reliable to identify subscribers with unauthorized electricity.