bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase‐Changeable Dynamic Conformal Electrode/electrolyte Interlayer enabling Pressure‐Independent Solid‐State Lithium Metal Batteries
Authors: Xu Hongfei , Zhu Qi , Zhao Yan , Du Zhiguo , Li Bin , Yang Shubin 
Published: February 2023

AbstractLithium‐metal‐based solid‐state batteries (Li‐SSBs) are one of the most promising energy storage devices due to their high energy densities. However, under insufficient pressure constraints (<MPa‐level), Li‐SSBs usually exhibit poor electrochemical performances owing to the continuous interfacial degradation between the solid‐state electrolyte (SSE) and electrodes. Herein, a phase‐changeable interlayer is developed to construct the self‐adhesive and dynamic conformal electrode/SSE contact in Li‐SSBs. The strong adhesive and cohesive strengths of the phase‐changeable interlayer enable Li‐SSBs to resist up to 250 N pulling force (=1.9 MPa), affording Li‐SSBs ideal interfacial integrality even without extra stack pressure. Remarkably, this interlayer exhibits a high ionic conductivity of 1.3 × 10−3 S cm−1, attributed to the shortened steric solvation hindrance and optimized Li+ coordination structure. Furthermore, the changeable phase property of the interlayer endows Li‐SSBs with a healable Li/SSE interface, accommodating the stress–strain evolution of the lithium metal and constructing the dynamic conformal interface. Consequently, the contact impedance of the modified solid symmetric cell exhibits a pressure‐independent manner and does not increase over 700 h (0.2 MPa). The LiFePO4 pouch cell with the phase‐changeable interlayer shows 85% capacity retention after 400 cycles at a low pressure of 0.1 MPa.
A Heteroanionic Zinc Ion Conductor for Dendrite‐Free Zn Metal Anodes
Authors: Zhao Siwei , Zhang Yujing , Li Jidao , Qi Limin , Tang Yuxin , Zhu Jia , Zhi Jian , Huang Fuqiang 
Published: February 2023

AbstractAlthough zinc‐based batteries are promising candidates for eco‐friendly and cost‐effective energy storage devices, their performance is severely retarded by dendrite formation. As the simplest zinc compounds, zinc chalcogenides, and halides are individually applied as a Zn protection layer due to high zinc ion conductivity. However, the mixed‐anion compounds are not studied, which constrains the Zn2+ diffusion in single‐anion lattices to their own limits. A heteroanionic zinc ion conductor (ZnyO1−xFx) coating layer is designed by in situ growth method with tunable F content and thickness. Strengthened by F aliovalent doping, the Zn2+ conductivity is enhanced within the wurtzite motif for rapid lattice Zn migration. ZnyO1−xFx also affords zincophilic sites for oriented superficial Zn plating to suppress dendrite growth. Therefore, ZnyO1−xFx‐coated anode exhibits a low overpotential of 20.4 mV for 1000 h cycle life at a plating capacity of 1.0 mA h cm−2 during symmetrical cell test. The MnO2//Zn full battery further proves high stability of 169.7 mA h g−1 for 1000 cycles. This work may enlighten the mixed‐anion tuning for high‐performance Zn‐based energy storage devices.
13% Single‐Component Organic Solar Cells based on Double‐Cable Conjugated Polymers with Pendent Y‐Series Acceptors
Authors: Liang Shijie , Xiao Chengyi , Xie Chengcheng , Liu Baiqiao , Fang Haisheng , Li Weiwei 
Published: February 2023

AbstractDouble‐cable conjugated polymers with pendent electron acceptors, including fullerene, rylene diimides, and nonfused acceptors, have been developed for application in single‐component organic solar cells (SCOSCs) with efficiencies approaching 10%. In this work, Y‐series electron acceptors have been firstly incorporated into double‐cable polymers in order to further improve the efficiencies of SCOSCs. A highly crystalline Y‐series acceptor based on quinoxaline core and the random copolymerized strategy are used to optimize the ambipolar charge transport and the nanophase separation of the double‐cable polymers. As a result, an efficiency of 13.02% is obtained in the random double‐cable polymer, representing the highest performance in SCOSCs, while the regular double‐cable polymer only provides a low efficiency of 2.75%. The significantly enhanced efficiencies are attributed to higher charge carrier mobilities, better ordering conjugated backbones and Y‐series acceptors in random double‐cable polymers.
Two‐Dimensional Organic Crystals Enabling Anisotropic Photon Transport and Dual‐Color Orthogonally Polarized Laser
Authors: Huang Han , Yang Liuqing , He Jingping , Yang Yongan , Yao Jiannian , Liao Qing , Fu Hongbing 
Published: February 2023

AbstractAnisotropic transport of polarized photons in organic 2D crystals provides a great opportunity to construct integrated photonic circuits. However, such study remains a critical challenge limited by the precise orientation of molecular transition dipole moment (TDM) and modification of the interaction between photons and molecular TDM. Herein, a stilbene derivative with strong solid‐state photoluminescence is designed and synthesized. The excellent anisotropic polarization‐dependent waveguide occurs in its parallelogram 2D crystal and further enables 463‐ and 493‐nm lasing emissions along the short and long axes of the crystal, respectively. Polarization measurements show that the two lasers with the different wavelengths have mutually orthogonal linear polarizations. These results provide a new strategy for designing orthogonally polarized lasers in single‐component 2D crystals, which may inspire further development of organic photonic devices with controllable polarization properties.
Short and Scalable Synthesis of Plant‐Based Cholesterol in GMP Grade
Authors: Munt Maxim , Spieß Oliver , Indolese Adriano , Roux Lionel , Giraud Matthieu , Schinzer Dieter 
Published: February 2023

AbstractA plant‐based straightforward and short four‐step synthesis of cholesterol starting from commercially available diosgenin is reported. This offers a large‐scale production of highly needed GMP‐grade cholesterol, which is part of the lipid cocktail for the assembly of effective mRNA‐based vaccines against the COVID‐19 pandemic. These lipids are formulated into the delivery system of the mRNA fragments by forming Lipid Nano Particles (LNP) that introduce the mRNA into the cells. Cholesterol plays a crucial role because it stabilizes LNP and facilitates endosome escape of the mRNA into the cytosol.
Process Controlled Ruthenium on 2D Engineered V‐MXene via Atomic Layer Deposition for Human Healthcare Monitoring
Authors: Mohapatra Debananda , Shin Yujin , Ansari Mohd Zahid , Kim Youn‐Hye , Park Ye Jin , Cheon Taehoon , Kim Haekyoung , Lee Jung Woo , Kim Soo‐Hyun 
Published: February 2023

AbstractIn searching for unique and unexplored 2D materials, the authors try to investigate for the very first time the use of delaminated V‐MXene coupled with precious metal ruthenium (Ru) through atomic layer deposition (ALD) for various contact and noncontact mode of real‐time temperature sensing applications at the human–machine interface. The novel delaminated V‐MXene (DM‐V2CTx) engineered ruthenium‐ALD (Ru‐ALD) temperature sensor demonstrates a competitive sensing performance of 1.11% °C−1 as of only V‐MXene of 0.42% °C−1. A nearly threefold increase in sensing and reversibility performance linked to the highly ordered few‐layered V‐MXene and selective, well‐controlled Ru atomic doping by ALD for the successful formation of Ru@DM‐V2CTX heterostructure. The advanced heterostructure formation, the mechanism, and the role of Ru have been comprehensively investigated by ultra‐high‐resolution transmission/scanning transmission electron microscopies coupled with next‐generation spherical aberration correction technology and fast, accurate elemental mapping quantifications, also by ultraviolet photoelectron spectroscopy. To the knowledge, this work is the first to use the novel, optimally processed V‐MXene over conventionally used Ti‐MXene and its surface‐internal structure engineering by Ru‐ALD process‐based temperature‐sensing devices function and operational demonstrations. The current work could potentially motivate the development of multifunctional, future, next‐generation, safe, personal healthcare electronic devices by the industrially scalable ALD technique.
One‐Step Synthesis of White‐Light‐Emitting Carbon Dots for White LEDs with a High Color Rendering Index of 97
Authors: Yan Zishan , Chen Tong , Yan Lingpeng , Liu Xinghua , Zheng Jingxia , Ren Fu‐de , Yang Yongzhen , Liu Bin , Liu Xuguang , Xu Bingshe 
Published: February 2023

AbstractWhite‐light‐emitting carbon dots (WCDs) show innate advantages as phosphors in white light‐emitting diodes (WLEDs). For WLEDs, the color rendering index (CRI) is the most important metric to evaluate its performance. Herein, WCDs are prepared by a facile one‐step solvothermal reaction of trimellitic acid and o‐phenylenediamine. It consists of four CDs identified by column chromatography as blue, green, yellow, red, and thus white light is a superposition of these four types of light. The mixture of the four CDs undergoes Förster resonance energy transfer to induce the generation of white light. The photoluminescence of WCDs originates from the synergistic effect of carbon core and surface states. Thereinto, the carbon core states dominate in RCDs, and the increase of amide contents and degree of conjugation promote the redshift of the emission spectra, which is further confirmed by theoretical calculations. In addition, a high CRI of 97 is achieved when the WCDs are used as phosphors to fabricate WLEDs, which is almost the highest value up to now. The multicolor LEDs can also be fabricated by using the four multicolor CDs as phosphors, respectively. This work provides a novel approach to explore the rapid preparation of low‐cost, high‐performance WCDs and CDs‐based WLEDs.
Water quality monitoring in recirculating aquaculture systems
Authors: Lindholm‐Lehto Petra 
Published: February 2023

AbstractGood water quality in recirculating aquaculture systems (RAS) is crucial for ensuring the successful growth and survival of reared species. So far, there are no regulations for which parameters should be measured in RAS, and each farmer decides which parameters to follow. Traditionally, water quality parameters have been measured at certain intervals with handheld sensors and laboratory analyses, which can be labour intensive. Currently, a variety of sensors and monitoring equipment is available, even for the real‐time monitoring of water quality parameters. Internet of Things‐based systems and artificial intelligence can be applied for the monitoring purposes which allows real‐time measurements and warnings of critical situations. However, many of the modern systems need competent users and require regular maintenance and calibration. Changes in water quality also induces changes in fish behaviour, such as swimming activity, depth, acceleration and water quality can be assessed also based on these changes. In this review, water quality parameters, variety of sensors and monitoring technologies have been summarised to provide an overview of the current monitoring systems for water quality. Additionally, analytical methods for more advanced analyses have also been briefly summarised. Although there are several advanced options available for monitoring the basic water quality parameters, real‐time measurements of more advanced parameters still required require further development.
The role of agricultural sector performance in attracting foreign direct investment in the food and beverages sector. Evidence from planned investments in Africa
Authors: Kubik Zaneta 
Published: February 2023

AbstractUsing a novel dataset on foreign direct investment (FDI), this paper analyzes the correlates of planned FDI in the food and beverages sector in 49 African countries over the period 2003–2017. It applies the random effects model and augments the standard specification of FDI determinants with a set of factors related to the agricultural sector performance, hypothesized to be essential from the perspective of supply chain linkages and access to raw materials. The results indicate that well‐performing and well‐capitalized agricultural sector of the host country is a key factor associated with the choice of investment location by foreign investors, especially those from the Global North. Capital investment in agriculture, as proxied by agricultural gross fixed capital formation and net capital stock, is particularly important. Public investment in agriculture, in the form of government expenditure and official development assistance, is also associated with higher FDI. These factors, however, are not significant in case of the least developed countries where only market potential appears to matter for foreign investors. The results suggest that complementarities may exist between different types of investments and that policy‐makers willing to attract food and beverages FDI should prioritize agricultural sector development. [EconLit Citations: E22, E24, F21, F23, Q00, Q13, Q18].
Shape dependent protein‐induced stabilization of gold nanoparticles: From a protein corona perspective
Authors: Tukova Anastasiia , Nie Yihan , Tavakkoli Yaraki Mohammad , Tran Ngoc Thanh , Wang Jiaqiu , Rodger Alison , Gu Yuantong , Wang Yuling 
Published: February 2023

AbstractAbstractGold nanoparticles (AuNPs) are promising materials for many bioapplications. However, upon contacting with biological media, AuNPs undergo changes. The interaction with proteins results in the so‐called protein corona (PC) around AuNPs, leading to the new bioidentity and optical properties. Understanding the mechanisms of PC formation and its functions can help us to utilise its benefits and avoid its drawbacks. To date, most of the previous works aimed to understand the mechanisms governing PC formation and focused on the spherical nanoparticles, although non‐spherical nanoparticles are designed for a wide range of applications in biosensing. In this work, we investigated the differences in PC formation on spherical and anisotropic AuNPs (nanostars in particular) from the joint experimental (extinction spectroscopy, zeta potential and surface‐enhanced Raman scattering [SERS]) and computational methods (the finite element method and molecular dynamics [MD] simulations). We discovered that protein does not fully cover the surface of anisotropic nanoparticles, leaving SERS hot‐spots at the tips and high curvature edges ‘available’ for analyte binding (no SERS signal after pre‐incubation with protein) while providing protein‐induced stabilization (indicated by extinction spectroscopy) of the AuNPs by providing a protein layer around the particle's core. The findings are confirmed from our MD simulations, the adsorption energy significantly decreases with the increased radius of curvature, so that tips (adsorption energy: 2762.334 kJ/mol) would be the least preferential binding site compared to core (adsorption energy: 11819.263 kJ/mol). These observations will help the development of new nanostructures with improved sensing and targeting ability.
Novel blended SNRPE‐related spliceosomopathy phenotype characterized by microcephaly and congenital atrichia
Authors: Amudhavalli Shivarajan M. , Paolillo V. , Lawson Caitlin , Patterson Melanie , Kussmann J. , Nopper A. J. , Lypka M. , Saunders Carol 
Published: February 2023

AbstractVariants in genes encoding core components of the spliceosomes are associated with craniofacial syndromes, collectively called craniofacial spliceosomopathies. SNRPE encodes a core component of pre‐mRNA processing U‐rich small nuclear ribonuclear proteins (UsnRNPs). Heterozygous variants in SNRPE have been reported in six families with isolated hypotrichosis simplex in addition to one case of isolated non syndromic congenital microcephaly. Here, we report a patient with a novel blended phenotype of microcephaly and congenital atrichia with multiple congenital anomalies due to a de novo intronic SNRPE deletion, c.82‐28_82‐16del, which results in exon skipping. As discussed within, this phenotype, which we propose be named SNRPE‐related syndromic microcephaly and hypotrichosis, overlaps other craniofacial splicesosomopathies.
Severe congenital neutropenia, SRP54 pathogenicity, and a framework for surveillance
Authors: Fan Elaine M. , Vagher Jennie , Meznarich Jessica A. , Ubico Erin Morales , Goteti Sasidhar , Peterson David , Rayes Ahmad , Maese Luke D. 
Published: February 2023

AbstractSevere congenital neutropenia (SCN) is a rare disorder, often due to pathogenic variants in genes such as ELANE, HAX1, and SBDS. SRP54 pathogenic variants are associated with SCN and Shwachman‐Diamond‐like syndrome. Thirty‐eight patients with SRP54‐related SCN are reported in the literature. We present an infant with SCN, without classic Shwachman‐Diamond syndrome features, who presented with recurrent bacterial infections and an SRP54 (c.349_351del) pathogenic variant. Despite ongoing granulocyte colony‐stimulating factor therapy, this patient has no evidence of malignant transformation. Here we establish a framework for the future development of universal guidelines to care for this patient population.
Influence of landscape structure on previous exposure to Leptospira spp. and Brucella abortus in free‐living neotropical primates from southern Brazil
Authors: dos Santos Elisandro O. , Klain Vinícius F. , B. Manrique Sebastián , Rodrigues Rogério O. , dos Santos Helton F. , Sangioni Luís A. , Dasso Maurício G. , de Almeida Marco A. B. , dos Santos Edmilson , Born Lucas C. , Reck José , Botton Sônia de Avila 
Published: February 2023

AbstractThe environments in which neotropical primates live have been undergoing an intense fragmentation process, constituting a major threat to the species' survival and causing resource scarcity, social isolation, and difficulty in dispersal, leaving populations increasingly vulnerable. Moreover, the proximity of wild environments to anthropized landscapes can change the dynamics of pathogens and the parasite‐host‐environment relationship, creating conditions that favor exposure to different pathogens. To investigate the previous exposure of free‐living primates in Rio Grande do Sul State (RS), southern Brazil, to the bacterial agents Leptospira spp. and Brucella abortus, we investigated agglutinating antibodies against 23 serovars of Leptospira spp. using the microscopic agglutination test and B. abortus acidified antigen test in primate serum samples; 101 samples from primates captured between 2002 and 2016 in different forest fragments were used: 63 Alouatta caraya, 36 Alouatta guariba clamitans, and 02 Sapajus nigritus cucullatus. In addition, the forest remnants where the primates were sampled were characterized in a multiscale approach in radii ranging from 200 to 1400 m to investigate the potential relationship of previous exposure to the agent with the elements that make up the landscape structure. The serological investigation indicated the presence of antibodies for at least one of the 23 serovars of Leptospira spp. in 36.6% (37/101) of the samples analyzed, with titers ranging from 100 to 1600. The most observed serovars were Panama (17.8%), Ballum (5.9%), Butembo (5.9%), Canicola (5.9%), Hardjo (4.9%), and Tarassovi (3.9%); no samples were seropositive for Brucella abortus. Decreased forest cover and edge density were the landscape factors that had a significant relationship with Leptospira spp. exposure, indicating that habitat fragmentation may influence contact with the pathogen. The data generated in this study demonstrate the importance of understanding how changes in landscape structure affect exposure to pathogenic microorganisms of zoonotic relevance. Hence, improving epidemiological research and understanding primates' ecological role in these settings can help improve environmental surveillance and conservation strategies for primate populations in different landscapes.
Homo medicus: The transition to meat eating increased pathogen pressure and the use of pharmacological plants in Homo
Authors: Hagen Edward H. , Blackwell Aaron D. , Lightner Aaron D. , Sullivan Roger J. 
Published: February 2023

AbstractThe human lineage transitioned to a more carnivorous niche 2.6 mya and evolved a large body size and slower life history, which likely increased zoonotic pathogen pressure. Evidence for this increase includes increased zoonotic infections in modern hunter‐gatherers and bushmeat hunters, exceptionally low stomach pH compared to other primates, and divergence in immune‐related genes. These all point to change, and probably intensification, in the infectious disease environment of Homo compared to earlier hominins and other apes. At the same time, the brain, an organ in which immune responses are constrained, began to triple in size. We propose that the combination of increased zoonotic pathogen pressure and the challenges of defending a large brain and body from pathogens in a long‐lived mammal, selected for intensification of the plant‐based self‐medication strategies already in place in apes and other primates. In support, there is evidence of medicinal plant use by hominins in the middle Paleolithic, and all cultures today have sophisticated, plant‐based medical systems, add spices to food, and regularly consume psychoactive plant substances that are harmful to helminths and other pathogens. We propose that the computational challenges of discovering effective plant‐based treatments, the consequent ability to consume more energy‐rich animal foods, and the reduced reliance on energetically‐costly immune responses helped select for increased cognitive abilities and unique exchange relationships in Homo. In the story of human evolution, which has long emphasized hunting skills, medical skills had an equal role to play.
Placental growth factor as a sensitive biomarker for vascular cognitive impairment
Authors: Hinman Jason D. , Elahi Fanny , Chong Davis , Radabaugh Hannah , Ferguson Adam , Maillard Pauline , Thompson Jeffrey F , Rosenberg Gary A. , Sagare Abhay , Moghekar Abhay , Lu Hanzhang , Lee Tiffany , Wilcock Donna , Satizabal Claudia L. , Tracy Russell , Seshadri Sudha , Schwab Kristin , Helmer Karl , Singh Herpreet , Kivisäkk Pia , Greenberg Steve , DeCarli Charlie , Kramer Joel 
Published: February 2023

AbstractINTRODUCTIONHigh‐performing biomarkers measuring the vascular contributions to cognitive impairment and dementia are lacking.METHODSUsing a multi‐site observational cohort study design, we examined the diagnostic accuracy of plasma placental growth factor (PlGF) within the MarkVCID Consortium (n = 335; CDR 0‐1). Subjects underwent clinical evaluation, cognitive testing, MRI, and blood sampling as defined by Consortium protocols.RESULTSIn the prospective population of 335 subjects (72.2 ± 7.8 years of age, 49.3% female), plasma PlGF (pg/mL) shows an ordinal odds ratio (OR) of 1.16 (1.07‐1.25; P = .0003) for increasing Fazekas score and ordinal OR of 1.22 (1.14‐1.32; P < .0001) for functional cognitive impairment measured by the Clinical Dementia Rating scale. We achieved the primary study outcome of a site‐independent association of plasma PlGF (pg/mL) with white matter injury and cognitive impairment in two of three study cohorts. Secondary outcomes using the full MarkVCID cohort demonstrated that plasma PlGF can significantly discriminate individuals with Fazekas ≥ 2 and CDR = 0.5 (area under the curve [AUC] = 0.74) and CDR = 1 (AUC = 0.89) from individuals with CDR = 0.DISCUSSIONPlasma PlGF measured by standardized immunoassay functions as a stable, reliable, diagnostic biomarker for cognitive impairment associated with substantial white matter burden.