bluuebunny/crossref_metadata_2025_split huggingface dataset:
DHHoE: Deep hybrid homogenous ensemble for digital histological breast cancer classification
Authors: Zerouaoui Hasnae , Idri Ali , El Alaoui Omar 
Published: July 2023

AbstractThe progress of deep learning architectures, machine learning models and pathology slide digitization is an encouraging step toward meeting the growing demand for more precise classification and prediction diagnosis for the breast tumours. The BreakHis dataset with four magnification factors (40X, 100X, 200X and 400X), as well as seven deep learning architectures used for feature extraction (DenseNet 201, Inception ResNet V2, Inception V3, ResNet 50, MobileNet V2,VGG16 and VGG19), four machine learning models for classification (MLP, SVM, DT, and KNN), and two combination rules (hard and weighted voting) were investigated in this paper to design and evaluate a new proposed approach consisting of building deep hybrid homogenous ensemble. Additionally, the best proposed models were compared to deep stacked, deep bagging, deep boosting, and deep hybrid heterogenous ensemble to choose the best strategy in building deep ensemble learning techniques. The four performance measures accuracy, precision, recall, and F1‐score were used in the empirical evaluations, as well as 5‐fold cross‐validation, the Scott Knott statistical test, and the Borda Count voting method. The results demonstrated the new approach's potential since it outscored both singles and other deep ensemble learning strategies, achieving accuracy values of 98.3% and 97.7% for the MFs 40X, 100X and 200X, 400X, respectively. The empirical results demonstrated that the proposed ensembles are impactful for histopathological breast cancer images classification, and they provided a promising tool to assist pathologists in the diagnosis of breast cancer.
Understanding how shared decision‐making approaches and patient aids influence patients with advanced cancer when deciding on palliative treatments and care: A realist review
Authors: Edwards Michelle , Holland‐Hart Daniella , Mann Mala , Seddon Kathy , Buckle Peter , Longo Mirella , Byrne Anthony , Nelson Annmarie 
Published: July 2023

AbstractBackgroundPatients with advanced incurable cancer face difficult decisions about palliative treatment options towards their end of life. However, they are often not provided with the appropriate information and support that is needed to make informed decisions. This review aimed to identify contexts and mechanisms associated with communication tools, patient decision‐aids and shared decision‐making (SDM) approaches that influence patient outcomes.MethodsWe used a realist review method to search for published studies of patients (adults > 18) with advanced cancer who were expected to make a decision about palliative treatment and/or supportive care in consultation with healthcare practitioners. We appraised and synthesised literature describing the contexts of (when and how) decision aids and SDM approaches are used, and how these contexts interact with mechanisms (resources and reasoning) which impact patient outcomes. Stakeholders including academics, palliative healthcare professionals (HCPs) and people with lived experience of supporting people with advanced incurable cancer contributed to identifying explanatory accounts. These accounts were documented, analysed and consolidated to contribute to the development of a programme theory.ResultsFrom the 33 included papers, we consolidated findings into 20 explanatory accounts to develop a programme theory that explains key contexts and mechanisms that influence patient and SDM. Contexts include underlying patients' and HCPs' attitudes and approaches. These need to be understood in relation to key mechanisms, including presenting information in multiple formats and providing adequate time and opportunities to prepare for and revisit decisions. Contexts influenced mechanisms which then influence the levels of patient decisional satisfaction, conflict and regret.ConclusionsOur programme theory highlights mechanisms that are important in supporting shared treatment decisions for advanced noncurative cancer. The findings are informative for developing and evaluating interventions to improve understanding and involvement in SDM for patients with advanced incurable cancer.Patient and Public ContributionWe included patient and public involvement (PPI) representatives in four stakeholder meetings. PPI helped to define the scope of the review, identify their unique experiences and perspectives, synthesise their perspectives with our review findings, make decisions about which theories we included in our programme theory and develop recommendations for policy and practice and future research.
Assessing psychometric properties of the Turkish version of the Fear of COVID‐19 Scale for Nurses
Authors: Hançerlioğlu Sadık , Toygar İsmail 
Published: July 2023

AbstractAimThe purpose of this study was to evaluate the validity and reliability of the Turkish version of the Fear of COVID‐19 Scale (FCV‐19S).MethodsThe study used a descriptive design and was conducted between April and May 2020. The participants were 213 nurses who were working in 12 hospitals in eight cities in Turkey. Content validity index, exploratory factor analysis and confirmatory factor analysis were used to evaluate validity. Cronbach's alpha, item‐scale correlation and test–retest reliability were used to evaluate reliability.ResultsThe CVI was 0.92 (0.81–1.00). A one‐factor solution was identified and the factor loading of items in scale varied from 0.377 to 0.909. The Cronbach's alpha value was 0.889 in the current study. Item‐scale correlations ranged between 0.570 and 0.815. Intraclass correlation coefficient ranged from 0.71 to 0.93.ConclusionThe Turkish version of the FCV‐19S for nurses was found to be valid and reliable measure of the fear of nurses towards COVID‐19.
Restricting CEO pay backfires: Evidence from China
Authors: Bae Kee‐Hong , Gong Zhaoran (Jason) , Tong Wilson H. S. 
Published: July 2023

AbstractUsing the pay restriction imposed on CEOs of centrally administered state‐owned enterprises (CSOEs) in China in 2009, we study the effects of limiting CEO pay. Compared with CEOs of firms not subject to the restriction, the CEOs of CSOEs experienced a significant pay cut. In response to the pay cut, CEOs increased the consumption of perks and siphoned off firm resources for their own benefit. Pay‐performance sensitivity for these firms also significantly decreases. The performance of these firms dropped following the pay restriction. Our findings suggest that restricting CEO pay distorts CEO incentives and brings unintended consequences. Our findings caution against limiting CEO pay.
A subtype of laminopathies: Generalized lipodystrophy‐associated progeroid syndrome caused by LMNA gene c.29C>T mutation
Authors: Huang Shipeng , Zhang Yan , Zhan Zuan , Gong Shuhao 
Published: July 2023

AbstractThe term laminopathies refers to a group of congenital diseases characterized by accelerated degeneration of human tissues. Mutations in LMNA, LMNB, ZMPSTE24, and other genes lead to structural and functional abnormalities associated with lamins. One subtype of laminopathy is the generalized lipodystrophy‐associated progeroid syndrome (GLPS), which occurs in patients with heterozygous mutations of the LMNA gene c.29C>T(p.T10I). This paper reports the first case of GLPS in China and compares the clinical features of other GLPS patients with literature reports. A 16‐year‐old male patient was treated for diabetic ketoacidosis, presenting with premature aging appearance, systemic lipodystrophy, severe fatty liver, and decreased bone density. After peripheral blood DNA extraction and second‐generation sequencing, a heterozygous mutation of exon 1 of the LMNA gene c.29C>T(p.T10I) was detected. This case of GLPS may provide a diagnostic and therapeutic basis for potential patients.
A decision‐making tree for evaluating an esthetically compromised single dental implant
Authors: Alrmali Abdusalam , Stuhr Sandra , Saleh Muhammad H. A. , Latimer Jessica , Kan Joseph , Tarnow Dennis P. , Wang Hom‐Lay 
Published: July 2023

AbstractObjectiveTo develop a comprehensive decision‐making tree for evaluating mid‐facial peri‐implant soft tissue dehiscence in the esthetic zone and provide a systematic approach for assessing various clinical case scenarios, determining appropriate treatment strategies, and considering factors such as the need for soft tissue augmentation, prosthetic changes, or implant removal.Clinical ConsiderationsThis clinical decision tree illustrates numerous case scenarios with various esthetic complications around an esthetically compromised, but clinically healthy single implant and provides clinicians with possible solutions as a predictable map for horizontal and vertical soft tissue augmentation in order to manage different clinical circumstances. According to current evidence, the key to treating such esthetic complications is the use of an adequate pre‐surgical prosthetic interdisciplinary approach with proper surgical techniques in order to optimize soft tissue dimensions and create better esthetic results. This may be accomplished through a purely surgical, combination of surgical and prosthetic, or purely prosthetic approaches.ConclusionsThe present report describes a series of successfully treated peri‐implant esthetic complication cases in accordance with the decision‐making tree that the authors recommend in order to achieve better long‐term esthetic outcomes.Clinical SignificanceThe combination of adequate pre‐surgical prosthetic interdisciplinary collaboration and proper surgical technique is critical in the optimization of sufficient soft tissue dimensions and contributes to a more highly esthetic result. This study demonstrates a clinical decision‐making tree to provide comprehensive, effective therapy of an esthetically compromised dental implant by using one of the following approaches: purely prosthetic, purely surgical, or a combination of surgical and prosthetic with or without abutment removal.
Isolated effect of filler particle size on surface properties of experimental resin composites before and after toothbrush abrasion
Authors: Kobayashi Mikihiro , Koi Kiyono , Wiskoski Sarah , Watanabe Hidehiko , Lewis Steven , Ferracane Jack L. 
Published: July 2023

AbstractObjectiveThis study aimed to isolate the relationship between filler size and the surface properties of roughness and gloss before and after toothbrush abrasion for experimental resin‐based composites (RBCs) containing uniform spherical fillers.Materials and MethodsFive experimental light‐cured RBCs with different spherical filler sizes and three commercial RBCs were studied. Forty specimens were polished using silicon carbide papers. Gloss was measured after 0, 90, 180, and 360 min of simulated toothbrushing, and surface roughness was measured before and after 360 min of toothbrushing. Two‐way ANOVA/Tukey's multiple comparison tests were used to compare the RBCs, and the correlation between particle size and surface roughness or gloss was also determined.ResultsAfter polishing and toothbrushing, RBCs with smaller fillers exhibited significantly higher gloss and lower surface roughness, and RBCs with larger fillers exhibited lower gloss and higher surface roughness. A significant correlation was found between filler particle size and gloss and surface roughness both before and after toothbrush abrasion.ConclusionsGloss of RBCs containing fillers with larger particle sizes was significantly reduced. After toothbrushing abrasion, the surface roughness increased for all RBCs, except those containing the finest‐sized fillers. The particle size of the filler is a critical determinant of the surface roughness and gloss of RBCs, after polishing and after toothbrushing.Clinical SignificanceIncreased surface roughness caused by toothbrush abrasion reduces the gloss of resin‐based composites. Resin‐based composites containing finer fillers best maintain glossiness after routine tooth brushing.
Cardiovascular autonomic neuropathy in patients with type 2 diabetes with and without sensorimotor polyneuropathy
Authors: Peters Emil , Itani Mustapha , Kristensen Alexander G. , Terkelsen Astrid Juhl , Krøigård Thomas , Tankisi Hatice , Jensen Troels S. , Finnerup Nanna B. , Gylfadottir Sandra Sif 
Published: July 2023

AbstractBackground and AimsCardiovascular autonomic neuropathy (CAN) in patients with diabetes is associated with poor prognosis. We aimed to assess signs of CAN and autonomic symptoms and to investigate the impact of sensorimotor neuropathy on CAN by examining type 2 diabetes patients with (DPN [distal sensorimotor polyneuropathy]) and without distal sensorimotor polyneuropathy (noDPN) and healthy controls (HC). Secondarily, we aimed to describe the characteristics of patients with CAN.MethodsA population of 374 subjects from a previously described cohort of the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) were included. Subjects were examined with the Vagus™ device for the diagnosis of CAN, where two or more abnormal cardiovascular autonomic reflex tests indicate definite CAN. Autonomic symptoms were assessed with Composite Autonomic Symptom Score 31 (COMPASS 31) questionnaire. DPN was defined according to the Toronto consensus panel definition.ResultsDefinite CAN was present in 22% with DPN, 7% without DPN and 3% of HC, and 91% of patients with definite CAN had DPN. Patients with DPN and definite CAN reported higher COMPASS 31 scores compared to patients with noDPN (20.0 vs. 8.3, p < 0.001) and no CAN (22.1 vs. 12.3, p = 0.01). CAN was associated with HbA1c and age in a multivariate logistic regression analysis but was not associated with IEFND or triglycerides.InterpretationOne in five patients with DPN have CAN and specific CAN characteristics may help identify patients at risk for developing this severe diabetic complication. Autonomic symptoms were strongly associated with having both DPN and CAN, but too unspecific for diagnosing CAN.
Changes in Social Relationships after Participation in a Group Intervention for Japanese Patients with Cancer: A Qualitative Study
Authors: Matsui Tomoko , Hirai Kei , Shokoji Masako , Nagatsuka Miwa , Tokuyama Madoka 
Published: July 2023

AbstractStudies of group interventions on social relationships among patients with cancer have suggested that such interventions can increase patients' social support and help build social support networks, which are expected to reduce the sense of loneliness among them. The purpose of this study was to qualitatively investigate the relationships between participation in group therapy and social relationships among patients with cancer. Seven participants with various types of cancer participated in group therapy and were interviewed at a medical institution in Japan. They were asked about changes in their social relationships after being affected with cancer and taking part in group therapy. We conducted qualitative analysis and identified 11 categories related to changes in social relationships after being diagnosed with cancer (e.g. “shrinkage or lack of social networks, weakening of density”). Six categories related to changes in social relations after taking part in group therapy were identified (e.g. “expanding support networks and increasing density”). The findings suggest that participation in group therapy may supplement the social relationships of patients with cancer who have experienced a reduction in, or insufficiency of, social relationships. In particular, we suggest that participants in group therapy might be receiving emotional/informational support and companionship from the other participants, including patients with the same disease, and from the medical staff.
Insomnia, poor sleep quality and perinatal suicidal risk: A systematic review and meta‐analysis
Authors: Palagini Laura , Cipriani Enrico , Miniati Mario , Bramante Alessandra , Gemignani Angelo , Geoffroy Pierre A. , Riemann Dieter 
Published: July 2023

SummarySuicidal risk in mothers is a public health priority. Risk factors include biological, psychological and psychosocial factors. Among the biological factors, the role of sleep disturbances as potential contributors to increased suicidal risk during the peripartum period is becoming apparent. To explore this further, we conducted a systematic review following the PRISMA criteria. Currently, 10 studies have examined the role of insomnia and poor sleep quality in suicidal risk during the peripartum period and have involved 807,760 women. The data showed that disturbed sleep and poor sleep quality increase the risk of suicidal ideation in both pregnant women with and without perinatal depression. The results of the meta‐analysis indicated that insomnia and poor sleep quality increase the odds of suicidal risk in pregnant women by more than threefold (OR = 3.47; 95% CI: 2.63–4.57). Specifically, the odds ratio (OR) for poor sleep quality was 3.72 (95% CI: 2.58–5.34; p < 0.001), and for insomnia symptoms, after taking into account perinatal depression, was 4.76 (95% CI: 1.83–12.34; p < 0.001). These findings emphasise the importance of assessing and addressing sleep disturbances during the peripartum period to mitigate their adverse effects on peripartum psychopathology and suicidal risk.
A genomic assessment of the marine‐speciation paradox within the toothed whale superfamily Delphinoidea
Authors: Westbury Michael V. , Cabrera Andrea A. , Rey‐Iglesia Alba , De Cahsan Binia , Duchêne David A. , Hartmann Stefanie , Lorenzen Eline D. 
Published: July 2023

AbstractThe impact of post‐divergence gene flow in speciation has been documented across a range of taxa in recent years, and may have been especially widespread in highly mobile, wide‐ranging marine species, such as cetaceans. Here, we studied individual genomes from nine species across the three families of the toothed whale superfamily Delphinoidea (Delphinidae, Phocoenidae and Monodontidae). To investigate the role of post‐divergence gene flow in the speciation process, we used a multifaceted approach, including (i) phylogenomics, (ii) the distribution of shared derived alleles and (iii) demographic inference. We found the divergence of lineages within Delphinoidea did not follow a process of pure bifurcation, but was much more complex. Sliding‐window phylogenomics reveal a high prevalence of discordant topologies within the superfamily, with further analyses indicating these discordances arose due to both incomplete lineage sorting and gene flow. D‐statistics and f‐branch analyses supported gene flow between members of Delphinoidea, with the vast majority of gene flow occurring as ancient interfamilial events. Demographic analyses provided evidence that introgressive gene flow has likely ceased between all species pairs tested, despite reports of contemporary interspecific hybrids. Our study provides the first steps towards resolving the large complexity of speciation within Delphinoidea; we reveal the prevalence of ancient interfamilial gene flow events prior to the diversification of each family, and suggest that contemporary hybridisation events may be disadvantageous, as hybrid individuals do not appear to contribute to the parental species' gene pools.
TOM1 family conservation within the plant kingdom for tobacco mosaic virus accumulation
Authors: Zhang Hui , Hu Qun 
Published: July 2023

AbstractThe susceptibility factor TOBAMOVIRUS MULTIPLICATION 1 (TOM1) is required for efficient multiplication of tobacco mosaic virus (TMV). Although some phylogenetic and functional analyses of the TOM1 family members have been conducted, a comprehensive analysis of the TOM1 homologues based on phylogeny from the most ancient to the youngest representatives within the plant kingdom, analysis of support for tobamovirus accumulation and interaction with other host and viral proteins has not been reported. In this study, using Nicotiana benthamiana and TMV as a model system, we functionally characterized the TOM1 homologues from N. benthamiana and other plant species from different plant lineages. We modified a multiplex genome editing tool and generated a sextuple mutant in which TMV multiplication was dramatically inhibited. We showed that TOM1 homologues from N. benthamiana exhibited variable capacities to support TMV multiplication. Evolutionary analysis revealed that the TOM1 family is restricted to the plant kingdom and probably originated in the Chlorophyta division, suggesting an ancient origin of the TOM1 family. We found that the TOM1 family acquired the ability to promote TMV multiplication after the divergence of moss and spikemoss. Moreover, the capacity of TOM1 orthologues from different plant species to promote TMV multiplication and the interactions between TOM1 and TOM2A and between TOM1 and TMV‐encoded replication proteins are highly conserved, suggesting a conserved nature of the TOM2A–TOM1–TMV Hel module in promoting TMV multiplication. Our study not only revealed a conserved nature of a gene module to promote tobamovirus multiplication, but also provides a valuable strategy for TMV‐resistant crop development.
Distinctive gastrointestinal motor dysfunction in patients with MNGIE
Authors: Alcalá‐González Luis G. , Accarino Anna , Martí Ramon , Sánchez‐Tejerina Daniel , Llauradó Arnau , Azpiroz Fernando , Malagelada Carolina 
Published: July 2023

AbstractBackgroundMitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare mitochondrial disease caused by mutations in TYMP, encoding thymidine phosphorylase. Clinically it is characterized by severe gastrointestinal dysmotility associated with cachexia and a demyelinating sensorimotor polyneuropathy. Even though digestive manifestations are progressive and invariably lead to death, the features of gastrointestinal motor dysfunction have not been systematically evaluated. The objective of this study was to describe gastrointestinal motor dysfunction in MNGIE using state‐of‐the art techniques and to evaluate the relationship between motor abnormalities and symptoms.MethodsProspective study evaluating gastrointestinal motor function and digestive symptoms in all patients with MNGIE attended at a national referral center in Spain between January 2018 and July 2022.Key ResultsIn this period, five patients diagnosed of MNGIE (age range 16–46 years, four men) were evaluated. Esophageal motility by high‐resolution manometry was abnormal in four patients (two hypoperistalsis, two aperistalsis). Gastric emptying by scintigraphy was mildly delayed in four and indicative of gastroparesis in one. In all patients, small bowel high‐resolution manometry exhibited a common, distinctive dysmotility pattern, characterized by repetitive bursts of spasmodic contractions, without traces of normal fasting and postprandial motility patterns. Interestingly, objective motor dysfunctions were detected in the absence of severe digestive symptoms.Conclusions and InferencesMNGIE patients exhibit a characteristic motor dysfunction, particularly of the small bowel, even in patients with mild digestive symptoms and in the absence of morphological signs of intestinal failure. Since symptoms are not predictive of objective findings, early investigation is indicated.
Plants out of place: How appreciation of weeds unsettles nature in New Zealand
Authors: Virens Abbi 
Published: July 2023

AbstractWeeds are known as ‘plants out of place’, but how do we come to understand what belongs in place and what does not? Organisms that thrive beyond boundaries of control threaten life that is ‘in place’, or nature. As a threat to life and nature, weeds are transformed into objects of hate and elimination. Exploring the collective hate of weeds helps to untangle the affective dimensions of colonisation. Using the story of the blackberry in Dunedin, both through its settler history and contemporary relationship with urban foragers, this paper describes how weeds have become powerful affective objects.