bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of irrigation water allocation, Koftu, Ethiopia
Authors: Hirko Deme Betele , Gebul Mekonen Ayana , Du Plessis Jakobus Andries , Emama Walabuma Oli 
Published: May 2023

Abstract
This research investigates the fair and efficient distribution of water among irrigators, focusing on the timely and uniform delivery of water. To achieve this, the study utilized various methods such as group discussions, critical informant and expert interviews, and field flow measurements. The degree of fairness in the distribution of irrigation water was determined by analyzing the shift in the relative water supply to end users. The effectiveness of irrigation is inversely proportional to the relative irrigation supply, which can be observed in the scheme's water delivery indicators. The study found that while the estimated delivered flow of water in the head, middle, and tail reaches of the canal was 1.21, 0.58, and 0.23 m3/s respectively, the required quantity of discharge was only 0.81, 0.31, and 0.15 m3/s. This discrepancy resulted in the inadequate, unreliable, and unequal water supply to irrigators. The research revealed that canal operation and maintenance were the main factors limiting the system's capacity. The findings showed that the adequacy, dependability, equality, and efficiency values were 0.8, 0.14, 0.40, and 0.71, respectively, suggesting that improvements are needed to ensure the timely and equitable distribution of water to irrigators.
Research Progress in Estrogen-related Receptor Gamma (ERRγ)
Agonists and Inverse Agonists
Authors: Zheng Yong , Du Yongli , Zhang Haibin , Lv Huiting , Yan Zhijia , Dong Ning , Li Qunyi , Wang Tianxiao 
Published: May 2023

Abstract:
Estrogen-related receptor gamma (ERRγ), one of three members of the ERR
family, is an inducible transcription factor. ERRγ has dual functions in different tissues.
The decreased expression of ERRγ in the brain, stomach, prostate, and fat cells can cause
neuropsychological dysfunction, gastric cancer, prostate cancer, and obesity. However,
when ERRγ is present in the liver, pancreas, and thyroid follicular cells, ERRγ overexpression
is related to liver cancer, type II diabetes, oxidative liver injury, and anaplastic
thyroid carcinoma. Signaling pathway studies have confirmed that ERRγ agonists or inverse
agonists can regulate ERRγ expression to treat related diseases. The collision between
residue Phe435 and the modulator is a key factor determining the activation or inhibition
of ERRγ. Although more than 20 agonists and inverse agonists of ERRγ have been
reported, no clinical studies have been found in the literature. This review summarizes
the important relationship between ERRγ-related signaling pathways and diseases, research
progress, and the structure-activity relationship of modulators. These findings provide
guidance for further study on new ERRγ modulators.
Advances in Chitosan-based Drug Delivery Systems in Melanoma: A
Narrative Review
Authors: Dana Parisa Maleki , Hallajzadeh Jamal , Asemi Zatollah , Mansournia Mohammad Ali , Yousefi Bahman 
Published: May 2023

Abstract:
Melanoma accounts for the minority of skin cancer cases. However, it has the
highest mortality rate among the subtypes of skin cancer. At the early stages of the disease,
patients show a good prognosis after the surgery, but developing metastases leads
to a remarkable drop in patients’ 5-year survival rate. Despite the advances made in the
therapeutic approaches to this disease, melanoma treatment is still facing several obstacles.
Systemic toxicity, water insolubility, instability, lack of proper biodistribution, inadequate
cellular penetration, and rapid clearance are some of the challenges that should be
addressed in the field of melanoma treatment. While various delivery systems have been
developed to circumvent these challenges, chitosan-based delivery platforms have indicated
significant success. Chitosan that is produced by the deacetylation of chitin can be formulated
into different materials (e.g., nanoparticle, film, and hydrogel) due to its characteristics.
Both in vitro and in vivo studies have reported that chitosan-based materials can
be used in drug delivery systems while offering a solution for the common problems in
this area, such as enhancing biodistribution and skin penetration as well as the sustained
release of the drugs. Herein, we reviewed the studies concerning the role of chitosan as a
drug delivery system in melanoma and discussed how these drug systems are used for delivering
chemotherapeutic drugs (e.g., doxorubicin and paclitaxel), genes (e.g., TRAIL),
and RNAs (e.g., miRNA199a and STAT3 siRNA) successfully. Furthermore, we take a
look into the role of chitosan-based nanoparticles in neutron capture therapy.
Lavender Plant: Farming and Health Benefits
Authors: Khan Sameer Ullah , Hamza Baseerat , Mir Reyaz Hassan , Fatima Kaneez , Malik Fayaz 
Published: May 2023

Abstract:
Natural remedies from a range of sources, including plants, animals,
microorganisms, and marine life, have made a significant contribution to the treatment of
many ailments. Lavender is a Mediterranean shrub from the Lamiaceae family. Lavender
flowers (Lavandula flores) include active ingredients (3%), anthocyanins, sugars,
phytosterols, minerals, and tannins and are majorly used for herbal applications.
Lavender essential oil's descriptive and analytical composition varies depending on
genotype, growing region, climatic circumstances, propagation, and morphological
characteristics. There are around 300 chemical components in essential oil. Linalool,
terpinen-4-ol, linalyl acetate, ocimene, acetate lavandulol, and cineole are the most
prominent constituents. Lavender oil has antibacterial and antioxidant properties. The
lavender extract helps to prevent dementia and may slow cancer cell growth, while
lavender oil is used to treat skin problems. This review will cover the recent medical,
economic and regional advancements in levander propagation and how the Council of
Scientific & Industrial Research Indian Institute of Integrative (CSIR IIIM) aroma mission
is actively acting as a bridge between farmers and their economic improvement by
attracting them to the field of medicinal plant cultivation.
Synthesis and Biological Properties of D-Amino Acids
Authors: Sharma Shikha , Sahoo Biswa Mohan , Banik Bimal Krishna 
Published: May 2023

Abstract:
In the past few years, scientists have learned more about how the human body uses D-amino acids and how their synthesis occurs. This has rekindled interest in researching them. D-amino acids are known to be important in an extensive variety of physiologic operations taking place inside the human body. The correlation between these radicals and the physiology of human beings is that D-aspartate and D-serine affect nerve signalling. Along with these, several other D-amino acids have also been linked to adjusting acquired immunity and the outcome of the gut barrier. Importantly, several conditions, including psychosis and amyotrophic lateral sclerosis, as well as age-related conditions, including cataracts and atherosclerosis, have been linked to the existence of D-amino acids within the human body. Also, there is more and more evidence that radicals interpret a role in the cause, progression, and treatment of cancer. This article will review the many approaches to synthesizing D-amino acids and their impact on the environment, animals, and the human body. In addition, scientific information addressing the methods of cytostatic action of D-amino acids as well as their prospective applications in industry and medicine, is included in this article.
Therapeutic Viewpoint on Rat Models of Locomotion Abnormalities and
Neurobiological Indicators in Parkinson's Disease
Authors: Chaudhary Rishabh , Singh Randhir 
Published: May 2023

Background:
Locomotion problems in Parkinson's syndrome are still a research and treatment
difficulty. With the recent introduction of brain stimulation or neuromodulation equipment that is
sufficient to monitor activity in the brain using electrodes placed on the scalp, new locomotion investigations
in patients having the capacity to move freely have sprung up.

Objective:
This study aimed to find rat models and locomotion-connected neuronal indicators and use
them all over a closed-loop system to enhance the future and present treatment options available for
Parkinson’s disease.

Methods:
Various publications on locomotor abnormalities, Parkinson's disease, animal models, and
other topics have been searched using several search engines, such as Google Scholar, Web of Science,
Research Gate, and PubMed.

Results:
Based on the literature, we can conclude that animal models are used for further investigating
the locomotion connectivity deficiencies of many biological measuring devices and attempting to address
unanswered concerns from clinical and non-clinical research. However, translational validity is required
for rat models to contribute to the improvement of upcoming neurostimulation-based medicines. This review
discusses the most successful methods for modelling Parkinson’s locomotion in rats.

Conclusion:
This review article has examined how scientific clinical experiments lead to localised
central nervous system injuries in rats, as well as how the associated motor deficits and connection oscillations
reflect this. This evolutionary process of therapeutic interventions may help to improve locomotion-
based treatment and management of Parkinson's syndrome in the upcoming years.
PENGEMBANGAN INSTRUMEN ASESMEN HASIL BELAJAR BERORIENTASI BERPIKIR TINGKAT TINGGI “TEMA PANAS DAN PERPINDAHANNYA” KELAS V SEKOLAH DASAR
Authors: S.N.R. Santiaga  , I.N. Sudiana  , I.W. Suastra  
Published: May 2023

Penelitian ini bertujuan untuk mengembangkan instrumen asesmen hasil belajar berorientasi berpikir tingkat tinggi pada pembelajaran tematik siswa kelas V Sekolah Dasar yang teruji secara validitas dan reliabilitas sebagai alat ukur. Metode penelitian yang digunakan adalah penelitian dan pengembangan (R&D) oleh Thiagarajan melalui tahapan 4D yaitu define, design, develop, dan disseminate. Penelitian yang dilakukan hanya sampai tahap develop (pengembangan). Subjek penelitian adalah 61 siswa kelas V SD yang terdiri atas 30 siswa dari SDN 6 Gianyar dan 31 siswa dari SD N 7 Gianyar. Pengujian instrumen dilakukan oleh 5 orang judges yaitu dua orang dosen ahli dan tiga orang praktisi dari Sekolah Dasar. Hasil validasi isi instrumen yaitu 20 soal dinyatakan valid dan siap digunakan. Analisis uji validitas empiris untuk instrumen asesmen hasil belajar tematik menggunakan rumus rxy korelasi product moment dengan berbantuan Microsoft Exel, diperoleh simpulan 20 soal valid dengan kategori 18 soal kategori derajat validitas sangat tinggi, 2 soal kategori derajat tinggi. Uji Reliabilitas instrumen asesmen hasil belajar dihitung menggunakan rumus Alpha Cronbach berbantuan Microsoft Exel. Berdasarkan hasil uji reliabilitas, diperoleh koefisien reliabilitas sebesar 0,98 dengan r table 0,60 sehingga dapat disimpulkan bahwa instrumen asesmen hasil belajar berorientasi berpikir tingkat tinggi dapat dinyatakan reliabel dengan derajat reliabilitas sangat tinggi didasarkan pada kriteria 0,80 < r11 <= 1,00.
Psychometric properties of the Insomnia Severity Index (ISI) in Mexican adults
Authors: Álvarez García Horacio Balam , Lugo-González Isaías Vicente , González Betanzos Fabiola 
Published: May 2023

Background: Insomnia is the sleep disorder with the highest incidence worldwide. It is estimated that this condition increases the risk of developing psychiatric, neurological, and cardiovascular problems. Due to this, it is important to have brief, reliable and valid psychometric instruments that allow health personnel their timely detection in first level health centers. Objectives: Analyze the psychometric properties of the Insomnia Severity Index (ISI) in its version adapted to Spanish in a sample of Mexican adults. Methods: The sample consisted of 310 adults, 223 (71.9%) women and 87 (28.1%) men. The comparison of four ISI measurement models of one, two and three factors and a bifactor model was carried out, its internal consistency was analyzed, an analysis of invariance by sex and correlation analysis with the Athens and Epworth scales. Results: The ISI bifactor model with a general factor (G) and a specific factor for insomnia impact (I) showed the best fit indices (χ2= 29.48, gl = 11, SRMR= 0.03, CFI= 0.98, TLI= 0.96, RMSEA= 0.07), and demonstrated configural, metric, and scalar invariance by sex. Adequate reliability was demonstrated by Omega coefficients (General: ωG= 0.86, Impact: ωI= 0.86) showed adequate reliability; the scale showed very strong correlations with the Athens scale (rAGoverall= 0.84; rAImpact=0.75) and weak to moderate correlations with the Epworth scale (rEGeneral= 0.39; rEImpact=0.44). Conclusions: The ISI bifactor version in Spanish presents adequate psychometric properties for the measurement of insomnia and, as it is a brief tool, it can be used at different levels of health care.
Low Earth Orbit Satellite Attitude Stabilization Using Linear Quadratic Regulator
Authors: Enejor Emmanuel U. , Dahunsi Folashade M. , Akingbade Kayode F. , Nelson Ibigbami O. 
Published: May 2023

This study compares the result of the PID controller to the LQR controller when used in the on-orbit stabilization of a satellite in the low earth orbit. The results from the PID controller show that the controller is too weak when used alone as the controller could not stabilize the system after 500 s which is not even allowable in practical application. For the LQR controller, a performance metric was set which is: i. the settling time is to be ≤ 10 seconds, ii. Maximum power consumption ≤ 1.5 Watts and iii. Zero (0) steady-state error / final value. The LQR controller meets system performance by achieving a settling time of roll (peak amplitude=0.26 s, settling time=10.0 s), Pitch (peak amplitude=0.395 s, settling time=5.52 s), Yaw (peak amplitude=0.350 s, settling time=5.52 s) and Total power consumption are 1.26 watt with a maximum torque of 3.22 mNm. Because power consumption and precision are critical in satellite applications, particularly military surveillance satellites. As a result, for an aerospace engineer to achieve their space mission, for instance, space mission like low earth orbit surveillance satellites, flexible solar panels, a high accuracy pointing accuracy, it will be impossible to adopt a PID controller except the engineer is ready for the complexity of design filters and compensators. An LQR design in this study can take care of all this complexity with minimum power consumption.
Análisis de las modalidades didácticas en arquitectura: sobre el taller, la formación y el saber proyectual
Authors: Rodriguez Lucas Gastón , Fiscarelli Diego Martin 
Published: May 2023

La docencia de la arquitectura demanda procesos complejos, tanto en su enseñanza como su aprendizaje. En tal sentido, este artículo propone analizar sus modalidades y métodos didácticos, indagando respecto de su pertinencia para la formación integral que supone el conocimiento proyectual. En consecuencia, se describen las características de la formación integral en arquitectura, el saber proyectual, la modalidad pedagógica de taller y los dispositivos didácticos de enchinchada y correcciones de proyecto. Se analizan las prácticas docentes en arquitectura, a partir de los métodos y estrategias pedagógicas clasificadas por las ciencias de la educación. Se expresan revisiones respecto del taller, las enchinchadas y las correcciones de proyecto. Y se concluye que la formación para el saber proyectual integra lo analítico, lo creativo y lo comunicativo.
Innovative principles of development by the management of educational institutions
Authors: Киреев С.П. , Дмитриев А.Г. 
Published: May 2023

В современном мире образование играет важную роль в развитии общества. Оно является основой для подготовки кадров, необходимых для развития экономики, науки и технологий. Управление образовательными учреждениями имеет большое значение для повышения качества образования и обеспечения эффективного функционирования системы образования. Современные технологии и инновации привносят в систему образования новые возможности и вызовы, требующие обновления методов управления. Цифровизация образования, повышение конкуренции на рынке образовательных услуг и изменение требований к подготовке специалистов являются вызовами, которым необходимо уметь противостоять. В данной статье рассмотрены инновационные принципы развития управлением образовательными учреждениями в России, методология управления образовательным учреждением, экономические принципы управления, а также эффективные способы управления вузом. Анализ этих аспектов позволит выявить наиболее эффективные подходы к управлению образовательными учреждениями, учитывающие вызовы современности.
In the modern world, education plays an important role in the development of society. It is the basis for the training of personnel necessary for the development of the economy, science and technology. The management of educational institutions is of great importance for improving the quality of education and ensuring the effective functioning of the education system. Modern technologies and innovations bring new opportunities and challenges to the education system that require updating management methods. Digitalization of education, increasing competition in the market of educational services and changing requirements for training specialists are challenges that need to be able to resist. This article discusses the innovative principles of development of management of educational institutions in Russia, the methodology of management of an educational institution, the economic principles of management, as well as effective ways of managing a university. The analysis of these aspects will reveal the most effective approaches to the management of educational institutions that take into account the challenges of our time.
EFFECTIVENESS OF LEARNING OUTCOMES OF TOURISM GEOGRAPHY TEXTBOOK FOR STUDENT IN GEOGRAPHY EDUCATION STUDY PROGRAM
Authors: Murtini Sri , Sutedjo Agus , Zain Ita Mardiani , Sabitah Sabrina Azharia 
Published: May 2023

This study aims to determine the effectiveness of the resulting textbook development subject Tourism Geography. Development textbook using the Borg and Gall model with five steps. The steps are (1) initial study to find problems related to geography teaching materials tourism as a product to be developed. (2) create planning development teaching materials, (3) develop products based on the problems found, ( 4 ) conduct field tests on the products being developed, and ( 5 ) revise to correct weaknesses in the field trial phase. The data were obtained from the teaching material validation team, which included material experts, linguists, and learning design experts. The validation results from the expert team showed the textbooks of tourism geography obtain values 92, 4, or category very suitable for learning. While data from the results study class of 2019 programming students subject tourism geography show effective results with an average value of 84.56 or category A-.
Keywords: effectiveness, textbooks, geography tourism, learning.
Associated deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in Switzerland, 2010 to 2019
Authors: Gasser Michael , Cassini Alessandro , Lo Fo Wong Danilo , Gelormini Marcello , Nahrgang Saskia Andrea , Zingg Walter , Kronenberg Andreas Oskar 
Published: May 2023

Background
Cassini et al. (2019) estimated that, in 2015, infections with 16 different antibiotic-resistant bacteria resulted in ca 170 disability-adjusted life-years (DALYs) per 100,000 population in the European Union and European Economic area (EU/EEA). The corresponding estimate for Switzerland was about half of this (87.8 DALYs per 100,000 population) but still higher than that of several EU/EEA countries (e.g. neighbouring Austria (77.2)).

Aim
In this study, the burden caused by the same infections due to antibiotic-resistant bacteria (‘AMR burden’) in Switzerland from 2010 to 2019 was estimated and the effect of the factors ‘linguistic region’ and ‘hospital type’ on this estimate was examined.

Methods
Number of infections, DALYs and deaths were estimated according to Cassini et al. (2019) whereas separate models were built for each linguistic region/hospital type combination.

Results
DALYs increased significantly from 3,995 (95% uncertainty interval (UI): 3;327–4,805) in 2010 to 6,805 (95% UI: 5,820–7,949) in 2019. Linguistic region and hospital type stratifications significantly affected the absolute values and the slope of the total AMR burden estimates. DALYs per population were higher in the Latin part of Switzerland (98 DALYs per 100,000 population; 95% UI: 83–115) compared with the German part (57 DALYs per 100,000 population; 95% UI: 49–66) and in university hospitals (165 DALYs per 100,000 hospitalisation days; 95% UI: 140–194) compared with non-university hospitals (62 DALYs per 100,000 hospitalisation days; 95% UI: 53–72).

Conclusions
The AMR burden estimate in Switzerland has increased significantly between 2010 and 2019. Considerable differences depending on the linguistic region and the hospital type were identified – a finding which affects the nationwide burden estimation.
Clinical epidemiology and case fatality due to antimicrobial resistance in Germany: a systematic review and meta-analysis, 1 January 2010 to 31 December 2021
Authors: Rödenbeck Maria , Ayobami Olaniyi , Eckmanns Tim , Pletz Mathias W , Bleidorn Jutta , Markwart Robby 
Published: May 2023

Background
Antimicrobial resistance (AMR) is of public health concern worldwide.

Aim
We aimed to summarise the German AMR situation for clinicians and microbiologists.

Methods
We conducted a systematic review and meta-analysis of 60 published studies and data from the German Antibiotic-Resistance-Surveillance (ARS). Primary outcomes were AMR proportions in bacterial isolates from infected patients in Germany (2016–2021) and the case fatality rates (2010–2021). Random and fixed (common) effect models were used to calculate pooled proportions and pooled case fatality odds ratios, respectively.

Results
The pooled proportion of meticillin resistance in Staphylococcus aureus infections (MRSA) was 7.9% with a declining trend between 2014 and 2020 (odds ratio (OR) = 0.89; 95% CI: 0.886–0.891; p < 0.0001), while vancomycin resistance in Enterococcus faecium (VRE) bloodstream infections increased (OR = 1.18; (95% CI: 1.16–1.21); p < 0.0001) with a pooled proportion of 34.9%. Case fatality rates for MRSA and VRE were higher than for their susceptible strains (OR = 2.29; 95% CI: 1.91–2.75 and 1.69; 95% CI: 1.22–2.33, respectively). Carbapenem resistance in Gram-negative pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Enterobacter spp. and Escherichia coli) was low to moderate (< 9%), but resistance against third-generation cephalosporins and fluoroquinolones was moderate to high (5–25%). Pseudomonas aeruginosa exhibited high resistance against carbapenems (17.0%; 95% CI: 11.9–22.8), third-generation cephalosporins (10.1%; 95% CI: 6.6–14.2) and fluoroquinolones (24.9%; 95% CI: 19.3–30.9). Statistical heterogeneity was high (I2 > 70%) across studies reporting resistance proportions.

Conclusion
Continuous efforts in AMR surveillance and infection prevention and control as well as antibiotic stewardship are needed to limit the spread of AMR in Germany.