bluuebunny/crossref_metadata_2025_split huggingface dataset:
Encountering the Past
Authors: Smith Claire , Brady Liam M. , Wilson Christopher 
Published: April 2023

Abstract
Ian McNiven recently argued that interpretive theoretical frameworks shaped by Indigenous worldviews offer the potential to enrich archaeological understandings of the past and inform archaeological practice in the present. In this chapter, the authors apply one of the core theoretical concepts McNiven identified—Indigenous experiences of encountering the past—to their work with Ngarrindjeri, Jawoyn, and Yanyuwa Aboriginal people. Through the lens of encountering the past, they focus on the notions of living landscapes, revelation by the ancestors, and ancestral remains as people, not objects. All three are underpinned by the concept of ancestors having and exerting agency that shapes how the ‘archaeological record’ is interpreted. In doing so, they are also contributing to research movements that seek to obtain interpretations of the past that are not only more closely aligned to the knowledge systems of the people who created the archaeological material and cultural landscapes but also grounded in emotional connections to people, place, and objects.
Spectral Moments
Authors: Campion Edmund 
Published: April 2023

Abstract
Already a formed composer upon his arrival in France in 1989, Edmund Campion began working with Gérard Grisey and interacting with other key figures and institutions in the Paris contemporary music scene. Beset by the powerful and contradictory forces shaping musical life in Paris at the time, Campion pursued an independent musical project, one that embedded many influences from the so-called spectral school. With a growing interest in computer-assisted composition, he was drawn to Gérard Grisey's overall thinking and practice, particularly his approach to time in music. Campion undertook a reworking of his musical identity, integrating some of the ideas and techniques of Grisey, while immersing himself in the rich musical communities throughout Paris. His music transformed in unexpected ways as he sought to translate and synthesize new influences. He describes his experiences and compositional transformations within the context of the confluence of competing musical concerns represented by the Paris Conservatory, the Groupe de Recherches Musicales (GRM), and Institut de Recherche et Coordination Acoustique/Musique (IRCAM).
The Adaptive Information Processing Model
Authors: Leeds Andrew M. 
Published: April 2023

Abstract
The Adaptive Information Processing (AIP) model is the theoretical foundation for the EMDR approach to psychotherapy. It guides all aspects of EMDR treatment including history taking, case conceptualization, preparation, memory reprocessing, and re-evaluation as treatment unfolds. The AIP model predicts treatment effects in posttraumatic stress disorder, stress-based anxiety disorders, and depressive disorders for which there is widespread research support, as well as in a range of less common and challenging to treat disorders. The AIP model proposes a bold yet concise framework by which psychological healing can be both comprehensive and rapid. It presents a compassionate framework for understanding and ameliorating human suffering and the evolution of consciousness.
Forging a Middlebrow Canon in Edwardian London
Authors: McVeigh Simon 
Published: April 2023

Abstract
The early years of the twentieth century saw the firming up of a middlebrow canon of orchestral music. Using London as a case study, this chapter explores the role of Sunday concerts in enabling new listeners to experience a core repertoire on a regular basis. Landon Ronald’s weekly concerts with the New Symphony Orchestra attracted audiences of eight thousand or more to the Royal Albert Hall, a reach extended through his portfolio of recordings for the Gramophone Company and through piano transcriptions for the domestic market. Combining an educational agenda with clear commercial objectives, Ronald was central to a middlebrow orchestral culture that has survived to the present day. Rather than endorsing a modernist critique of the middlebrow, the chapter argues that British audiences at his concerts were not merely passive consumers but took part in an active discourse about repertoire and programming.
Introduction
Authors: De Souza Jonathan , Steege Benjamin , Wiskus Jessica 
Published: April 2023

Abstract
This introduction presents a critical overview of the phenomenology of music, examining its origins, history, limits, and future possibilities. Since Plato, Western discourse about music has articulated a conflict between music’s mathematical, objective properties and its effects on embodied, situated human subjects. Edmund Husserl, the founder of phenomenology, approached similar philosophical problems via a theory of intentionality. If consciousness is always intentional (i.e., directed toward things), then there is an essential correlation between the subject and the world. Since 1900, phenomenological analysis of musical problems has taken several forms: (1) from around 1910 to 1940, a quest to define the very object of musical phenomenology in opposition to the contemporaneous trend toward a “naturalistic” music aesthetics; (2) from around 1940 to 1970, greater concern with aesthetic production (including both performance and modernist poetics); (3) from around 1970 to around 2000, the prioritization of musical “experience” as a counterweight to music-theoretical abstractions; and (4) from 2000 to the present, a growing acknowledgment of embodiment, technology, and the interaction of the two. ​​Because musical form is generated through time, because we make and feel music with our bodies and instruments, because music communicates shared meaning with others, and because music is performed in diverse social contexts, a phenomenology of music must work with key themes of phenomenology itself—time-consciousness, embodiment, intersubjectivity, and the lifeworld.
The Modifying Mirror
Authors: Taipale Joona 
Published: April 2023

Abstract
This chapter compares music listening with the infant’s experience of care. Several scholars have argued that music can be used for scaffolding one’s self-experience. Developmental psychologists, in turn, maintain a wide consensus over the claim that, in early interaction, the attuned caregiver supports and modifies the infant’s self-experience in various ways. The chapter brings these phenomena together, illustrating how the examination of the early self/other relation can teach us something important concerning the listener/music relation. The first section elaborates on the scaffolding function of music and clarifies two ambiguities haunting the debate. The second section relocates musical scaffolding in the register of vitality forms. Once the third section has dealt with early interaction, and analyzed the basic functions of the attuned caregiver, the fourth section uses the gained insights to examine the structural similarities between music listening and early experiences of attunement. Ultimately, this investigation reveals the “thanatic function” of music.
Historical Events That Shaped Contemporary Opioid Trends
Authors: Dunn Kelly E. 
Published: April 2023

Abstract
Opioid products originate in Papaver somniferum (e.g., the poppy plant), a naturally occurring botanical plant whose psychoactive ingredient (opium) has been used for centuries for its analgesic and reinforcing properties. In the mid-1800s the psychoactive ingredient of opium, morphine, was isolated and identified, leading to the medicalization of opioid products. In the 1900s, opioids were viewed primarily as useful therapeutics that were often compounded with other psychoactive ingredients and sold as elixirs. Within 20 years there was strong recognition of their potential for problematic use related to high rates of opioid-related problems. While the scientific field continued to focus on the identification and synthesis of new opioid analgesics, at a Federal level a series of acts were passed that sought to restrict access to opioids. This made for a complex environment to enact treatment programs, and many of the laws passed during those periods continue to shape our modern-day treatment infrastructure. Nonmedical opioid use continued throughout the 20th century, though it changed in important ways beginning around the 1980s when a series of landmark events occurred, each of which are believed to have played a role in shaping the current state of opioid use in the United States. This chapter provides a historical review of the experience of opioids, primarily in the United States, from the 1800s to today and discusses in detail how these events established a foundation upon which our contemporary medical, treatment, and societal approaches are premised.
Kratom (Mitragyna speciosa)
Authors: Smith Kirsten E. , Grundmann Oliver , Swogger Marc T. , Garcia-Romeu Albert 
Published: April 2023

Abstract
Kratom (Mitragyna speciosa) is a tree in the coffee family, indigenous to Southeast Asia (SEA), whose leaves have historically been used as a natural remedy and for its purported stimulating and analgesic properties. Kratom has gained popularity in recent years in the United States, where internet-based sales have driven growing numbers of people to experiment with kratom products. Kratom contains over 40 unique alkaloids displaying complex pharmacological properties including opioid- and non-opioid-receptor mediated effects. Data from animal research indicates therapeutic potential of kratom; for instance, as an analgesic agent or in mitigating opioid and alcohol withdrawal symptoms. Some adverse effects and risks are also attributable to kratom and its alkaloids, including possible liver damage and potential for dependence, particularly in the context of high dosage and/or chronic administration. However, in comparison to commonly used opioid medications, these risks are generally lower for kratom, consistent with human observational data from SEA and the US. Prevalence of kratom use remains difficult to conclusively assess, with estimates ranging between 1.8 to 15.6 million kratom-using adults in the US alone. The limited human data, comprised of survey and case report, suggest kratom may be effective for pain relief, to address mood and anxiety symptoms, and as a potential future aid in the treatment of substance use disorders and drug withdrawal. Overall, limited data indicate kratom and its alkaloids warrant a significant investment of rigorous basic and clinical research to better characterize its pharmacology, potential risks, and therapeutic benefits.
CAT within forensic settings part one
Authors: Ramm Mark , Shannon Karen 
Published: April 2023

Abstract
Cognitive analytic therapy (CAT) has a wide range of useful applications within forensic services. In addition to the more established use of CAT with clinical problems, it is equally helpful for understanding and addressing offending behaviour. CAT-based formulations can also make an important contribution to risk assessment and risk management. In addition, CAT can provide staff with a shared and consistent framework to guide and maintain the consistency of interventions in a context where a fundamental tension exists between the demands of managing risk and rehabilitation. CAT’s relational approach can become the main mechanism for achieving positive change particularly when individuals who have offended find it hard to engage. CAT can act as an overarching model to integrate forensic services, with contextual and systemic reformulation guiding service delivery at the organizational level. This chapter describes these applications of CAT in forensic services and highlights the available literature in this area.
Love and Infidelity
Authors: Carroll Noël 
Published: April 2023

Abstract
Polling shows that Americans believe that infidelity—commonly called “cheating”—is morally wrong. This chapter pursues the question of what—beyond the fact that it typically involves lying—is morally wrong about infidelity in cases that involve partners who are engaged in enduring romantic relationships that are presumed to be exclusive and permanent. The author argues that the most significant moral wrongs in such cases are based on the psychological damage the betrayer inflicts upon the betrayed in the relevant sorts of enduring romantic relationships. These relationships are constituted by means of a wealth of reciprocally transforming joint projects that shape the self-image of the partners in profound ways. The discovery of infidelity undermines that self-image in a way that typically engenders psychic injuries such as paranoia, self-doubt, and a lack of self-esteem, among other psychological wounds that are not only painful in their own right, but that may impair future behavior. Even when said infidelities go undetected, the betrayed lover is harmed insofar as he/she/they is deprived of the full range of choices available—such as exiting the relationship altogether.
The role of antidrug antibodies in ustekinumab therapy and the impact of methotrexate
Authors: Mojtahed Poor Sorwe , Henke Marina , Ulshöfer Thomas , Köhm Michaela , Behrens Frank , Burkhardt Harald , Schiffmann Susanne 
Published: April 2023

Abstract

Objective
We investigated the impact of concomitant MTX on ustekinumab (UST) levels and antidrug antibody (ADA) formation in PsA and evaluated consequences in pharmacodynamics and pharmacokinetics.

Methods
We conducted a post-hoc analysis on 112 PsA serum samples of subjects treated with open-label UST and either concomitant MTX (UST/MTX, n = 58) or placebo (UST/pbo, n = 54) obtained in a randomized (1:1), double-blind, multicentre trial. A validated antibody-binding-based multitiered testing was used to detect ADA and ADA with neutralizing capacity (nADA). The impact of MTX on UST immunogenicity was analysed by comparison of UST/pbo with UST/MTX cohorts at different time points. Patient- and disease-related predispositions for ADA formation were investigated with multiple linear regression analysis. Immunogenicity impact on pharmacokinetics, safety and efficacy was determined by cohort comparison between patients with and without ADA formation.

Results
Over 52 weeks, 11 UST/pbo- and 19 UST/MTX-treated patients developed ADA (P &gt; 0.05). In the UST/pbo cohort, the visit-dependent UST levels were in the range of 0.047 (0.05) –0.110 (0.07) µg/ml overall, and 0.037 (0.04)–0.091 (0.08) µg/ml in ADA-confirmed subjects. In UST/MTX-treated patients, the UST levels exhibited an intervisit variation in the range of 0.0502 (0.04)–0.106 (0.07) µg/ml overall and 0.029 (0.03)–0.097 (0.07) µg/ml in ADA positive subjects (P &gt; 0.05). At week 52, ADA-confirmed patients did not differ significantly (P &gt; 0.05) in safety or clinical outcomes from ADA-negative patients.

Conclusion
Concomitant MTX had no significant impact on UST immunogenicity. Furthermore, ADA formation was not associated with impairments in UST safety, efficacy or trough levels.

Trial registration
ClinicalTrials.gov, https://clinicaltrials.gov, NCT03148860.
A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo
Authors: Tsai Han-Hsuan Doris , House John S , Wright Fred A , Chiu Weihsueh A , Rusyn Ivan 
Published: April 2023

Abstract
Hazard evaluation of substances of “unknown or variable composition, complex reaction products and biological materials” (UVCBs) remains a major challenge in regulatory science because their chemical composition is difficult to ascertain. Petroleum substances are representative UVCBs and human cell-based data have been previously used to substantiate their groupings for regulatory submissions. We hypothesized that a combination of phenotypic and transcriptomic data could be integrated to make decisions as to selection of group-representative worst-case petroleum UVCBs for subsequent toxicity evaluation in vivo. We used data obtained from 141 substances from 16 manufacturing categories previously tested in 6 human cell types (induced pluripotent stem cell [iPSC]-derived hepatocytes, cardiomyocytes, neurons, and endothelial cells, and MCF7 and A375 cell lines). Benchmark doses for gene-substance combinations were calculated, and both transcriptomic and phenotype-derived points of departure (PODs) were obtained. Correlation analysis and machine learning were used to assess associations between phenotypic and transcriptional PODs and to determine the most informative cell types and assays, thus representing a cost-effective integrated testing strategy. We found that 2 cell types—iPSC-derived-hepatocytes and -cardiomyocytes—contributed the most informative and protective PODs and may be used to inform selection of representative petroleum UVCBs for further toxicity evaluation in vivo. Overall, although the use of new approach methodologies to prioritize UVCBs has not been widely adopted, our study proposes a tiered testing strategy based on iPSC-derived hepatocytes and cardiomyocytes to inform selection of representative worst-case petroleum UVCBs from each manufacturing category for further toxicity evaluation in vivo.
A meta-analysis on the prevalence of Taenia solium and Taenia saginata infections in India
Authors: Balodhi Ashutosh , Jain Khushi , Gupta Palak , Deeba Farah , Salam Nasir 
Published: April 2023

ABSTRACT
Tapeworm infections in humans are considered to be a significant public health menace. Despite its public health importance, the data on tapeworm infection remains fragmented and underutilised. The present study reviews the overall burden and distribution of taeniasis and cysticercosis caused by Taenia solium and Taenia saginata in India by conducting a systematic review of the scientific literature based on Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines.
Data from 19 eligible articles were analysed and the prevalence of T. solium–associated taeniasis/cysticercosis was found to be 11.06% (95% confidence interval [CI] 6.856 to 16.119) and the prevalence of T. saginata–associated taeniasis was found to be 4.7% (95% CI 3.301 to 6.301). This systematic review and meta-analysis provides a comprehensive analysis of the available literature on tapeworm infections and assesses the burden of Taenia infection from India, identifying areas of high prevalence requiring active surveillance and public health interventions.
Glutamatergic melanocortin‐4 receptor neurons regulate body weight
Authors: Liu Haodong , Li Xiaojing , Li Penghui , Hai Rihan , Li Jiacheng , Fan Qi , Wang Xing , Chen Yujie , Cao Xiaojuan , Zhang Xiaoyu , Gao Ruifeng , Wang Kun , Du Chenguang 
Published: April 2023

AbstractThe locus coeruleus (LC), enriched in vesicular glutamate transporter 2 (VGlut2) neurons, is a potential homeostasis‐regulating hub. However, the identity of melanocortin‐4 receptor (MC4R) neurons in the paraventricular nucleus (PVN) of the hypothalamus, PVNVGlut2::MC4R and LCVGlut2::MC4R regulation of body weight, and axonal projections of LCVGlut2 neurons remain unclear. Conditional knockout of MC4R in chimeric mice was used to confirm the effects of VGlut2. Interscapular brown adipose tissue was injected with pseudorabies virus to study the central nervous system projections. We mapped the LCVGlut2 circuitry. Based on the Cre–LoxP recombination system, specific knockdown of MC4R in VGlut2 neurons resulted in weight gain in chimeric mice. Adeno‐associated virus‐mediated knockdown of MC4R expression in the PVN and LC had potential superimposed effects on weight gain, demonstrating the importance of VGlut2 neurons. Unlike these wide‐ranging efferent projections, the PVN, hypothalamic arcuate nucleus, supraoptic nucleus of the lateral olfactory tegmental nuclei, and nucleus tractus solitarius send excitatory projections to LCVGlut2 neurons. The PVN → LC glutamatergic MC4R long‐term neural circuit positively affected weight management and could help treat obesity.
MENIN‐mediated regulation of gastrin gene expression and its role in gastrinoma development
Authors: Elvis‐Offiah Uloma B. , Duan Suzann , Merchant Juanita L. 
Published: April 2023

AbstractThe Multiple Endocrine Neoplasia I (MEN1) locus encodes the protein MENIN, which functions as a tumor suppressor protein in neuroendocrine tissues. Gastrinomas are neuroendocrine neoplasms that overproduce the hormone gastrin and can arise sporadically or as part of the MEN1 syndrome, in which mutations in the MEN1 gene lead to loss or inactivation of MENIN protein. Gastrin is a peptide hormone that is primarily synthesized in the gastric antrum and stimulates the secretion of histamine from enterochromaffin‐like (ECL) cells and subsequently acid from parietal cells in the gastric corpus. In addition, gastrin exerts a mitogenic function primarily on ECL cells and progenitor cells in the gastric isthmus. Current studies seek to understand how MEN1 mutations generate a mutant MENIN protein that abrogates its tumor suppressor function. Mutations in the MEN1 gene are broadly distributed throughout its nine protein‐coding exons, making it difficult to correlate protein structure with its function. Although disruption of the Men1 locus in mice causes functional neuroendocrine tumors in the pituitary and pancreas, gastrinomas do not develop in these transgenic animal models. Prior studies of human gastrinomas suggest that tissue‐specific microenvironmental cues in the submucosal foregut may contribute to tumorigenesis by reprogramming of epithelial cells toward the neuroendocrine phenotype. Accordingly, recent studies suggest that neural crest‐derived cells are also sensitive to reprogramming when MEN1 is deleted or mutated. Thus, the goal of this report is to review our current understanding of how MENIN modulates gastrin gene expression while highlighting its role in the prevention/suppression of neuroendocrine cell transformation.
Large Sternoabdominal Wound Dehiscence after Cardiac Surgery: Challenging Multimodal Treatment
Authors: Bundele Varsha , Aggarwal Neha , Bana Ajeet 
Published: April 2023

ABSTRACT
The authors report the case of a patient who presented with a nonhealing sternal wound 3 months after cardiac bypass surgery. The patient was treated with vacuum-assisted closure, surgical debridement, and IV antibiotics. Despite repeated flap closure procedures, a top closure device, and wound dressings, the patient developed an infection, and the wound size increased from 8 × 10 cm to 20 × 20 cm, advancing from the sternal to upper abdominal region. This wound was then treated with hyperbaric oxygen therapy and nonmedicated dressings until the patient was eligible to receive a split-thickness skin graft 1.5 years after initial presentation.
The main takeaway from this case was that local and systemic factors affected the outcome of each surgical closure. The failure of each preceding treatment choice that led to further increases in size and area of the wound was the main challenge. Eliminating infection, preventing development of new infection, and managing the local and systemic factors before any definite surgery are key to the eventual wound closure.