bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping ethical issues in the use of smart home health technologies to care for older persons: a systematic review
Authors: Felber Nadine Andrea , Tian Yi Jiao (Angelina) , Pageau Félix , Elger Bernice Simone , Wangmo Tenzin 
Published: January 2023

Abstract
Background

The worldwide increase in older persons demands technological solutions to combat the shortage of caregiving and to enable aging in place. Smart home health technologies (SHHTs) are promoted and implemented as a possible solution from an economic and practical perspective. However, ethical considerations are equally important and need to be investigated.

Methods

we conducted a systematic review according to the PRISMA guidelines to investigate if and how ethical questions are discussed in the field of SHHTs in caregiving for older persons.

Results

156 peer-reviewed articles published in English, German and French were retrieved and analyzed across 10 electronic databases. Using narrative analysis, 7 ethical categories were mapped: privacy, autonomy, responsibility, human vs. artificial interactions, trust, ageism and stigma, and other concerns.

Conclusions

The findings of our systematic review show the (lack of) ethical consideration when it comes to the development and implementation of SHHTs for older persons. Our analysis is useful to promote careful ethical consideration when carrying out technology development, research and deployment to care for older persons.

Registration

We registered our systematic review in the PROSPERO network under CRD42021248543
Urban Stream Corridors and Forest Patches – The Connections: A Case Study of Bloomington, IN
Authors: Luchauer Gretchen , Freeman-Day Stephanie , Fischer Burnell 
Published: January 2023

Abstract
Streams and forests are connected ecosystems, but few studies have looked at the connectivity between streams and forests in urban environments. City-made decisions affect connections between streams and forests by isolating both streams and forests. Streams are often channelized or buried to reduce flooding and increase potential developable areas. Forests become fragmented and are removed unless they are protected by public ownership, private ownership, or mixed governance arrangements. Historical choices in land usage affect the sites and sizes of current urban streams, forests, and development. This affects the distribution of impervious surfaces, a ubiquitous urban land cover type, which separates streams from forests. Despite these barriers to stream/forest interactions, cities can experience stream/forest connectivity. Seven Bloomington watersheds are ranked on their proportions of buried streams, channelized streams, forested hydrology, forested streams, urban forest patch cover, and impervious surface cover, along with historical presence of urbanization. Several watersheds demonstrate stream/forest connectivity, with five of these watersheds containing 50% or greater forested stream segments. Bloomington canopy cover reduces stormwater runoff by approximately 127 kiloliters per year. These forested areas reduce flooding, reduce nutrient loading, and reduce stream conditions associated with urban stream syndrome. Streams provide incentive for forest protection, aesthetic value, and recreational value. Understanding urban stream/forest connectivity can improve green infrastructure design and green space design, which improves urban resilience and better connects residents to the environment.
Microwave assisted extraction of polyphenols from Pithecellobium dulce benth fruit peels and evaluation of its anticancer and antioxidant activity
Authors: Murugesan Selvakumar , Maran Prakash , Venkatesan Manigandan , Alexander Ronaldo Anuf 
Published: January 2023

Abstract
Polyphenols are great interest in recent decades due to the potential health benefits such as protection against development of carcinoma, diabetes, obesity, osteoporosis neurodegenerative and cardiovascular diseases etc. Therefore, researchers and scientists have been more interested in the extraction of polyphenols from plant resources. The present study investigates the microwave-assisted extraction of polyphenols from the Pithecellobium dulce fruit peels. ANOVA pareto analysis and Response surface methodology was employed to analyse the effect of process variables on delignification. Four independent process variables such as microwave irradiation power, microwave irradiation time, pH and Liquid to solid ratio (LSR) were analysed. Microwave-assisted aqueous extraction facilitated in maximum yield of polyphenols from the fruit peels (79.18 mg GAE/g dw). The polyphenol extract exhibited potential antioxidant (IC50 of 63.18 µg/ml) and anticancer (LD50 of 61.3 µg/ml) activity using radical scavenging DPPH and MTT assay respectively. Therefore, our study indicates that the polyphenolics rich, biologically potent Pithecellobium dulce fruit peel extracts can be a good therapeutic and nutraceutical supplement to treat cancer and related complications.
A Comparative Assessment of Forest/green Cover and the Awareness of Forestry District Managers
Authors: Çeler Erda , Serengil Yusuf , Özkan Ufuk 
Published: January 2023

Abstract
Forests in and around the cities are becoming crucial in climate adaptation as the severity and frequency of heat waves, and urban heat islands are estimated to increase in the coming decades. As the local forestry authority, the forest district manager's role in establishing and managing forested green spaces in and around the cities is essential. The study is based on a land cover analysis, in selected provinces of Türkiye, for a period of three decades. We compared the responses of district forest managers to understand their awareness and perception of urban green areas and related climate change issues. The survey was sent to all district forest managers of the State Forest Service (GDF) and responded to by 69 from 28 provinces. The major land cover maps used were explicitly developed for land cover analysis by the GDF with temporal points of 1990, 2000, and 2015. To calculate the urban forest cover in the city centers, we used the city limit delineation shapefiles produced by the EU Copernicus program. We also employed the land consumption rate/population growth rate metric to reveal and discuss the provinces' land and forest cover changes. The results showed that forest district managers were aware of the general condition of the forests in their provinces. Still, there was a considerable inconsistency between actual land use changes (i.e., deforestation) and their responses. The study also revealed that the forest managers were aware of the increasing influence of climate change issues but were not knowledgeable enough to establish the connection between their tasks and climate change. It has been concluded that the national forestry policy should prioritize the urban-forest interaction and develop the capacities of district forest managers to improve the efficiency of climate policies on a regional scale.
Management of the axilla in postmenopausal patients with cN0 hormone receptor-positive/ HER2-negative breast cancer treated with neoadjuvant endocrine therapy and its prognostic impact.
Authors: Garcia-Tejedor Amparo , Fernandez-Gonzalez Sergi , Laplana Maria , Gil-Gil Miguel , Martinez Evelyn , Calvo Iris , Calpelo Hugo , Ortega Raul , Petit Anna , Guma Anna , Campos Miriam , Stradella Agostina , López-Ojeda Ana 
Published: January 2023

Abstract
Purpose
To evaluate the differences when performing the sentinel lymph node biopsy (SLNB) before or after neoadjuvant endocrine therapy (NET) in breast cancer patients, and the impact of its timing on prognosis.
Methods
A retrospective cohort study including 91 postmenopausal cases with clinically node-negative and hormone receptor-positive/HER2 negative (HR+/HER2-) breast cancer, treated with NET and SLNB at our institution. SLNB was performed pre-NET until 2014, and post-NET thereafter. Axillary lymph node dissection (ALND) was indicated only in SLNB-macrometastasis, although in selected elderly patients it was omitted. Kaplan-Meier survival curves were obtained in relation to the status of the axilla, and the differences assessed using the log-rank test.
Results
Between December 2006 and March 2022, SLNB was performed pre-NET in 14 cases and post-NET in 77. SLNB-positivity was similar regardless of whether SLNB was performed before or after NET (35.7% and 37%, respectively), with 2/14 SLN macrometastases in the pre-NET cohort and 17/77 in the post-NET cohort. Only three patients (18.7%) with SLN macrometastasis had > 3 positive nodes following axillary node dissection. The 5-year overall survival and distant disease-free survival were 92.4% and 94.8% respectively, with no significant differences according to SLNB status.
Conclusion
SLN positivity did not differ according to its timing (before or after NET). Therefore, NET has no effect on lymph node clearance. Furthermore, the prognosis is good regardless of the axillary involvement. Therefore, factors other than axillary involvement may affect the prognosis in these patients.
Glucocorticoids alleviate particulate matter-induced COX-2 expression and mitochondrial dysfunction through the Bcl-2/GR complex in A549 cells
Authors: Park Yeon-Ji , Kim Yonghyeon , Cho Hyeseong , Lim Wonchung 
Published: January 2023

Abstract
Exposure to particulate matter (PM) causes mitochondrial dysfunction and lung inflammation. The cyclooxygenase-2 (COX-2) pathway is important for inflammation and mitochondrial function. However, the mechanisms by which glucocorticoid receptors (GRs) suppress COX-2 expression during PM exposure have not been elucidated yet. Hence, we examined the mechanisms underlying the dexamethasone-mediated suppression of the PM-induced COX-2/prostaglandin E2 (PGE2) pathway in A549 cells. The PM-induced increase in COX-2 protein, mRNA, and promoter activity was suppressed by glucocorticoids; this effect of glucocorticoids was antagonized by the GR antagonist RU486. COX-2 induction was correlated with the ability of PM to increase reactive oxygen species (ROS) levels. Consistent with this, antioxidant treatment significantly abolished COX-2 induction, suggesting that ROS is involved in PM-mediated COX-2 induction. We also observed a low mitochondrial membrane potential in PM-treated A549 cells, which was reversed by dexamethasone. Moreover, glucocorticoids significantly enhanced Bcl-2/GR complex formation in PM-treated A549 cells. Glucocorticoids regulate the PM-exposed induction of COX-2 expression and mitochondrial dysfunction and increase the interaction between GR and Bcl-2. These findings suggest that the COX-2/PGE2 pathway and the interaction between GR and Bcl-2 are potential key therapeutic targets for the suppression of inflammation under PM exposure.
The Impact of COVID-19 Vaccination on the Sexual Health of Males
Authors: BAŞER Aykut , BAŞER Hülya YILMAZ , GÜZEL Ahmet 
Published: January 2023

Abstract
The COVID-19 pandemic negatively affected the mental and sexual health of individuals, especially healthcare professionals. In this study, we aimed to investigate the changes in anxiety and sexual activity of male healthcare professionals following vaccination. This prospective cross-sectional and descriptive online survey study was conducted between July 1, 2021 and November 1, 2021, involving a total of 170 healthcare professionals. Socio-demographic characteristics, pre- and post-vaccination anxiety and sexual activity levels of the participants were compared. There was a significant increase in only intercourse times of the participants before and after vaccination (p=0.034). The Beck anxiety scale score decreased from (median: 19, min: 16, max: 47) before vaccination to (median: 17, min: 10, max: 43) after vaccination (p<0.001). Likewise, Arizona Sexual Experiences Scale scores decreased after vaccination (median: 10, min: 5, max: 20) compared to before vaccination (median: 12, min: 5, max: 18) (p<0.001). International Index of Erectile functon(IIEF) score also increased after vaccination (25.49±6.50) compared to before vaccination (24.71±7.10) (p<0.001). Orgasmic Function, Sexual Desire, Intercourse Satisfaction, Overall Satisfaction scores also improved (p=0.013, p<0.001, p=0.027, p<0.001). Mental and Sexual disorders increased with the COVID-19 pandemic. In addition to immunity, the vaccine also has positive effects on anxiety and sexual activity.
Rehabilitation progress following reverse total shoulder replacement or internal fixation for geriatric three and four-part proximal humerus fractures – A propensity score matched comparison
Authors: TONG Chi Him , FANG Christian Xinshuo 
Published: January 2023

Abstract
Background
Proximal humerus fracture is one of the most common fractures in the elderly population. However, in patients with complex fracture patterns, there is still no general consensus in the best treatment method. This study aims to evaluate the outcomes between those treated with reverse total shoulder arthroplasty (rTSA) and internal fixation (IF).
Methods
All geriatric patients with proximal humerus fractures undergoing surgical treatment were analysed. There were 25 patients treated with rTSA and 175 with IF. All patients followed a protocol-driven rehabilitation programme with outcome assessment at 3, 6, 12 and 24 months. Constant score, qDASH, range of motion, rate of complications and revision surgery were recorded and compared. Propensity score matching was used to select 25 matching patients from the IF group according to age and gender.
Results
25 rTSA were age and gender matched with 25 IF patients. At a mean follow up of 3, 6, 12 and 24 months respectively, average constant shoulder score was 37.7/55.2/68.1/72.8 for rTSA and 45.5/60.0/64.6/70.8 for IF. Mean qDASH scores were 50.6/18.2/11.0/4.50 for rTSA and 29.4/18.5/18.4/11.0 for IF. Mean forward flexion range was 72.9/104/136/143 for rTSA and 94.4/108/109/109 for IF. Mean shoulder abduction range was 64.0/105/125/135 for rTSA and 88.6/106/108/110 for IF. There were more complications observed for IF (3) than rTSA (1) (p = 0.297) and more re-operations for IF (3) than rTSA (1) (p = 0.297).
Conclusion
rTSA appears to yield a slower recovery before 6 months but a better outcome at 2 years. It may be the preferred treatment for geriatric three- and four-part proximal humerus fracture, for those aiming for a better long-term functional outcome.
Impact of “black rock” on clinical outcomes after endovascular therapy for de novo calcified femoropopliteal lesions
Authors: Mori Shinsuke , Yamawaki Masahiro , Shirai Shigemitsu , Makino Kenji , Chishiki Toshiki , Honda Yohsuke , Tsutsumi Masakazu , Hiraishi Mana , Kobayashi Norihiro , Ito Yoshiaki 
Published: January 2023

Abstract
Purpose
The relationship between severity of calcification and clinical outcomes after endovascular therapy (EVT) for femoropopliteal lesions is well known. We often encounter dense calcifications in our daily practice, which are darker than normal calcifications on angiography. Accordingly, we named it “black rock” (BR), and investigated its impact on clinical outcomes after EVT.
Materials and methods
We retrospectively analyzed 677 lesions in 495 patients who underwent EVT for de novo calcified femoropopliteal lesions at our hospital between April 2007 and June 2020. BR is defined as a calcification which is 1 cm or more in length, occupies more than half of the vessel diameter, and appears darker than the body of the femur on angiography.
Propensity score matching analysis was performed to compare clinical outcomes between lesions with BR [BR (+) group] and without BR [BR (−) group].
Results
A total of 124 matched pairs of lesions were analyzed. Primary patency at 2 years was significantly lower in the BR (+) group than in the BR (−) group (48% vs. 75%, p = .0007). Multivariate analysis revealed that BR [hazard ratio (HR) = 2.23, 95% confidence interval (CI); 1.48–3.38, p = .0001], lesion length (HR = 1.03, 95%CI; 1.00–1.06, p = .0244), and scaffold use (HR = 0.63, 95%CI; 0.42–0.94, p = .0246) were predictors of restenosis.
Conclusion
BR is independently associated with clinical outcomes after EVT for de novo calcified femoropopliteal lesions.
Level of Evidence: Level 4
Remimazolam-remifentanil causes less postoperative nausea and vomiting than remimazolam-alfentanil during hysteroscopy: A single‐centre randomized controlled trial
Authors: Zhang Xiaoqiang , Li Shuang , Liu Jing 
Published: January 2023

Abstract
Background: Although the operation time of hysteroscopy is short, the incidence of postoperative nausea and vomiting (PONV) is high. Research shows that remimazolam besylate combined with remifentanil is safe and effective for anaesthesia during hysteroscopy. Alfentanil is a short-acting opioid drug with low respiratory inhibition, less cough and fast metabolism, thus making it suitable for daily surgical anaesthesia. Remimazolam is a new benzodiazepine drug that can be as effective in preventing PONV as midazolam. When remimazolam is compounded, it has the best compatibility with remifentanil and alfentanil to reduce PONV. The aim of this study was to compare the incidence of PONV between administration of remimazolam-remifentanil and remimazolam-alfentanil during hysteroscopy.
Methods: We conducted a randomized, controlled, double-blind trial. Patients undergoing hysteroscopy were recruited and randomly assigned to either the remimazolam-remifentanil (Group RR) or the remimazolam-alfentanil group (Group RA).
All patients in the two groups were started with an induction dose of remimazolam besylate 0.2 mg/kg and then maintained with a dosage of 1.0 mg/kg/h. After induction with remimazolam besylate, for Group RR, remifentanil was infused using a target-controlled infusion system with a target concentration of 1.5 ng/ml and titrated throughout the procedure.
For Group RA, infusion of alfentanil was started with an initial bolus dose of 20 µg/kg over 30 s and then maintained at an initial rate of 0.16 µg/kg/min. The primary observation outcome was the incidence rate of PONV. The secondary observation outcomes were hypoxemia during the operation and other adverse effects, such as bradycardia, hypotension and body movement.
Results: A total of 204 patients were successfully included in this study. The incidence of PONV in Group RR (2/102, 2.0%) was significantly lower than that in Group RA (12/102, 11.8%) (p<0.05). There were no significant differences in the incidence of other adverse events, such as low SpO2, bradycardia, hypotension and body movement, between the RR and RA groups (p>0.05).
Conclusions: Remimazolam-remifentanil causes less PONV than remimazolam-alfentanil during hysteroscopy.
Trial registration
Clinical trial registration number: ChiCTR2100044177. Full date of the frst registration: 12/03/2021.
Size and wave exposure shape parrotfish distributions and function in shallow coral reefs
Authors: Pinto Wenzel , Patel Farai Divan , Dey Mayukh , Alcoverro Teresa , Arthur Rohan 
Published: January 2023

Abstract
Wave exposure is a powerful environmental filter in shallow coral reefs, influencing species distributions and mediating patterns of decline and recovery. How mobile species navigate wave regimes is often mediated by size, morphology and swimming behaviour. How species navigate turbulent wave regimes is especially important in the case of functionally important groups like parrotfish. We explored how wave exposure shapes the distribution, biomass and bioerosional role of parrotfish assemblages in coral reefs using in-water visual surveys in the Lakshadweep Archipelago. Despite being relatively fusiform, we found that parrotfish distribution was strongly influenced by wave exposure, mediated by individual size and body shape. There was a clear decoupling between density, biomass and bioerosion in relation to wave regimes. Parrotfish density was highest in shallow exposed sites, dominated by large shoals of small individuals with low body depth ratios. In contrast, biomass was highest in deeper locations, where larger individuals were most abundant. This differential filtering of species and sizes resulted in considerable heterogeneity in the spatial distribution of bioerosional processes on the reef. Our study highlights the importance of size and shape as critical traits in influencing community assembly and determining the distribution of function in parrotfish.
Case Report of Infectious endocarditis complicated by lumbar purulent spondylitis diagnosed by acute radial artery occlusion
Authors: Horie Kana , Aoyama Rie , Iidaka Kazunobu , Ishiwaki Hikaru , Okino Shinichi , Fukuzawa Shigeru , Fujii Masahiko , Sakurai Manabu , Mogi Kenji 
Published: January 2023

Abstract
Introduction; Infective endocarditis (IE) is a rare but serious disease with a wide range of phenotypes and clinical courses. The diagnosis of IE is often difficult and must be comprehensively judged. Case Presentation; We report the case of a 78-year-old woman with back pain and fever of unknown origin, who was transferred to our hospital due to acute radial artery occlusion. We diagnosed purulent spondylitis and IE. The mobile vegetation remained in the anterior mitral valve leaflet after embolism, and the embolism to the central nervous system was relatively mild, so we decided to perform early surgery. Mitral valve replacement was performed because of embolic symptoms without further complications. Conclusions; Early evaluation by echocardiography is required for the prompt diagnosis of IE and its associated high-risk features may benefit from surgical intervention. Early diagnosis of infective endocarditis and surgical intervention are associated with better outcome in patients with large vegetations, recurrent embolisms, and heart failure. While purulent spondylitis is not commonly associated with infective endocarditis, it is important to actively suspect the existence of IE in patients who complain of back pain along with fever. Both physicians and orthopedic surgeons need to recognize IE as a common disease, especially in the elderly society.
A multidimensional thin film based PUF as new approach to Strong PUFs
Authors: Malthiery Benjamin , Wagner Estelle , Benvenuti Giacomo 
Published: January 2023

Abstract
Physical Unclonable Functions (PUFs) are expected to overcome a number of constraints mainly encountered in the security of the Internet of Things (IoT) domain. They are supposed to be an effective approach to protect objects against counterfeiting by providing unique identities to them through applications such as authentication and key generation in digital environments. To evaluate their security potential, it is essential to quantify their randomness that is intimately related to the fabrication process. It is the reason why previous works were mainly motivated by developing solutions that improved the randomness without inducing overhead on other concerns such as cost, power consumption and integrability. The present work focuses on the diversification capability offered by complex patterned oxide thin films obtained through Chemical Beam Vapour Deposition (CBVD) to be used as PUF and discusses the relevance of this solution from a conceptual point of view. A major advantage consists in the possibility to benefit from a large range of different physico-chemical properties that can additionally be evaluated by a large panel of different characterization techniques, that provide huge encoding capacity as they evaluate to different randomly distributed values at each point. As with all constructions of PUF, the challenge is then to define appropriate additional blocks to optimize the uniformity, reproducibility, and uniqueness of the PUF responses. The concept of a fully miniaturized and integrated optical PUF based on the thin film fingerprints is described, as very promising solution.