bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast Cancer Survivors’ Returning to Work: An Observational Study
among Active Women, Two Years after Diagnosis
Authors: Bouzgarrou Lamia , Laajili Hayet , Slama Mohamed Anis , Omrane Amira , Ben Afia Latifa , Kammoun Salma 
Published: January 2023

Background:
Breast Cancer is one of the most frequently diagnosed cancers among women
all over the world.

Objective:
The purpose of this study is to identify determinants of breast cancer and evaluate the effectiveness
of return to work as a result of early diagnosis.

Methods:
A cross-sectional survey was conducted in a university hospital dedicated to women's health
and gynecology. It investigated the return to work among women diagnosed with breast cancer at least
two years and at most five years before the onset of the survey.

Results:
At the time of the investigation, 72% of patients returned to work. The initially occupied
workstation was regained by 5% of women. The loss of the position occupied before cancer diagnosis
was significantly associated with the age at diagnosis time (p = 0.02), the prívate working sector (p =
0.014), and with blue-collar professional category (p = 0.02). Nevertheless, the higher likelihood of
returning to active life after breast cáncer was significantly associated with early diagnosis and better
health assessment (p = 0.01).

Conclusion:
Returning to work among breast cáncer survivors is important for everyday life recovery.
The professional recovery may be improved by early diagnosis and multidisciplinary interventions.
Using Clinical Data Visualizations in Electronic Health Record User Interfaces to Enhance Medical Student Diagnostic Reasoning: Randomized Experiment
Authors: Cheng Lucille , Senathirajah Yalini 
Published: January 2023

Background
In medicine, the clinical decision-making process can be described using the dual-process theory consisting of the fast, intuitive “System 1,” commonly seen in seasoned physicians, and the slow, deliberative “System 2,” associated with medical students. System-1—type diagnostic reasoning is thought to be less cognitively burdensome, thereby reducing physician error. To date, limited literature exists on inducing System-1–type diagnosis in medical students through cognitive heuristics, particularly while using modern electronic health record (EHR) interfaces.

Objective
In this experimental pilot study, we aimed to (1) attempt to induce System-1—type diagnostic reasoning in inexperienced medical students through the acquisition of cognitive user interface heuristics and (2) understand the impact of clinical patient data visualizations on students' cognitive load and medical education.

Methods
The participants were third- and fourth-year medical students recruited from the University of Pittsburgh School of Medicine who had completed 1+ clinical rotations. The students were presented 8 patient cases on a novel EHR, featuring a prominent data visualization designed to foster at-a-glance rapid case assessment, and asked to diagnose the patient. Half of the participants were shown 4 of the 8 cases repeatedly, up to 4 times with 30 seconds per case (Group A), and the other half of the participants were shown cases twice with 2 minutes per case (Group B). All participants were then asked to provide full diagnoses of all 8 cases. Finally, the participants were asked to evaluate and elaborate on their experience with the system; content analysis was subsequently performed on these user experience interviews.

Results
A total of 15 students participated. The participants in Group A scored slightly higher on average than those in Group B, with a mean percentage correct of 76% (95% CI 0.68-0.84) versus 69% (95% CI 0.58-0.80), and spent on average 50% less time per question than Group B diagnosing patients (13.98 seconds vs 19.13 seconds, P=.03, respectively). When comparing the novel EHR design to previously used EHRs, 73% (n=11) of participants rated the new version on par or higher (3+/5). Ease of use and intuitiveness of this new system rated similarly high (mean score 3.73/5 and 4.2/5, respectively). In qualitative thematic analysis of poststudy interviews, most participants (n=11, 73%) spoke to “pattern-recognition” cognitive heuristic strategies consistent with System 1 decision-making.

Conclusions
These results support the possibility of inducing type-1 diagnostics in learners and the potential for data visualization and user design heuristics to reduce cognitive burden in clinical settings. Clinical data presentation in the diagnostic reasoning process is ripe for innovation, and further research is needed to explore the benefit of using such visualizations in medical education.
Global, Regional, and National Burden of CKD due to Glomerulonephritis from 1990 to 2019
Authors: Hu Junjie , Ke Runjiang , Teixeira Wilhem , Dong Yimin , Ding Rong , Yang Jincui , Ai Xing , Ye Da-Wei , Shang Jiwen 
Published: January 2023

Background
CKD is becoming a major human health concern. Limited quantitative assessments of the burden of CKD due to glomerulonephritis have been performed. We performed a comprehensive analysis of the disease burden to update the epidemiology of this disease.

Methods
Incidence, prevalence, deaths, and disability-adjusted life-years (DALYs) data and percent changes in these indicators were extracted from Global Burden of Disease Study 2019 to analyze the burden of CKD due to glomerulonephritis.

Results
Globally, there were 606,300 (95% uncertainty interval [UI], 560,100 to 658,100) incident patients, 17,300,000 (95% UI, 16,100,000 to 18,600,000) prevalent patients, 183,700 (95% UI, 146,300 to 228,900) deaths, and 6,900,000 (95% UI, 5,900,000 to 8,100,000) DALYs of CKD due to glomerulonephritis in 2019. Compared with those in 1990, the numbers of incident patients, prevalent patients, deaths, and DALYs increased by 77%, 81%, 100%, and 66%, respectively. Most of the disease burden was concentrated in countries with lower sociodemographic index. In Central Latin America, the disease burden was much higher than expected on the basis of its sociodemographic index. Decomposition analysis showed that population aging and growth were the two major drivers of the increase in DALYs. Frontier analysis revealed considerable opportunities to reduce the age-standardized DALYs in the middle of the sociodemographic-index spectrum. Although middle-aged and elderly individuals accounted for the majority of the disease burden, the highest incidence rate was observed in children aged 1–4 years.

Conclusions
The disease burden of CKD due to glomerulonephritis has increased worldwide, especially in regions and countries with lower sociodemographic indexes.
Evaluating Kidney Function Decline in Children with Chronic Kidney Disease Using a Multi-Institutional Electronic Health Record Database
Authors: Gluck Caroline A. , Forrest Christopher B. , Davies Amy Goodwin , Maltenfort Mitchell , Mcdonald Jill R. , Mitsnefes Mark , Dharnidharka Vikas R. , Dixon Bradley P. , Flynn Joseph T. , Somers Michael J. , Smoyer William E. , Neu Alicia , Hovinga Collin A. , Skversky Amy L. , Eissing Thomas , Kaiser Andreas , Breitenstein Stefanie , Furth Susan L. , Denburg Michelle R. 
Published: January 2023

Background
The objectives of this study were to use electronic health record data from a US national multicenter pediatric network to identify a large cohort of children with CKD, evaluate CKD progression, and examine clinical risk factors for kidney function decline.

Methods
This retrospective cohort study identified children seen between January 1, 2009, to February 28, 2022. Data were from six pediatric health systems in PEDSnet. We identified children aged 18 months to 18 years who met criteria for CKD: two eGFR values <90 and ≥15 ml/min per 1.73 m2 separated by ≥90 days without an intervening value ≥90. CKD progression was defined as a composite outcome: eGFR <15 ml/min per 1.73 m2, ≥50% eGFR decline, long-term dialysis, or kidney transplant. Subcohorts were defined based on CKD etiology: glomerular, nonglomerular, or malignancy. We assessed the association of hypertension (≥2 visits with hypertension diagnosis code) and proteinuria (≥1 urinalysis with ≥1+ protein) within 2 years of cohort entrance on the composite outcome.

Results
Among 7,148,875 children, we identified 11,240 (15.7 per 10,000) with CKD (median age 11 years, 50% female). The median follow-up was 5.1 (interquartile range 2.8–8.3) years, the median initial eGFR was 75.3 (interquartile range 61–83) ml/min per 1.73 m2, 37% had proteinuria, and 35% had hypertension. The following were associated with CKD progression: lower eGFR category (adjusted hazard ratio [aHR] 1.44 [95% confidence interval (95% CI), 1.23 to 1.69], aHR 2.38 [95% CI, 2.02 to 2.79], aHR 5.75 [95% CI, 5.05 to 6.55] for eGFR 45–59 ml/min per 1.73 m2, 30–44 ml/min per 1.73 m2, 15–29 ml/min per 1.73 m2 at cohort entrance, respectively, when compared with eGFR 60–89 ml/min per 1.73 m2), glomerular disease (aHR 2.01 [95% CI, 1.78 to 2.28]), malignancy (aHR 1.79 [95% CI, 1.52 to 2.11]), proteinuria (aHR 2.23 [95% CI, 1.89 to 2.62]), hypertension (aHR 1.49 [95% CI, 1.22 to 1.82]), proteinuria and hypertension together (aHR 3.98 [95% CI, 3.40 to 4.68]), count of complex chronic comorbidities (aHR 1.07 [95% CI, 1.05 to 1.10] per additional comorbid body system), male sex (aHR 1.16 [95% CI, 1.05 to 1.28]), and younger age at cohort entrance (aHR 0.95 [95% CI, 0.94 to 0.96] per year older).

Conclusions
In large-scale real-world data for children with CKD, disease etiology, albuminuria, hypertension, age, male sex, lower eGFR, and greater medical complexity at start of follow-up were associated with more rapid decline in kidney function.
Metabolomic Markers of Ultra-Processed Food and Incident CKD
Authors: Su Donghan , Chen Jingsha , Du Shutong , Kim Hyunju , Yu Bing , Wong Kari E. , Boerwinkle Eric , Rebholz Casey M. 
Published: January 2023

Background
High ultra-processed food consumption is associated with higher risk of CKD. However, there is no biomarker for ultra-processed food, and the mechanism through which ultra-processed food is associated with CKD is not clear. Metabolomics can provide objective biomarkers of ultra-processed food and provide important insights into the mechanisms by which ultra-processed food is associated with risk of incident CKD. Our objective was to identify serum metabolites associated with ultra-processed food consumption and investigate whether ultra-processed food–associated metabolites are prospectively associated with incident CKD.

Methods
We used data from 3751 Black and White men and women (aged 45–64 years) in the Atherosclerosis Risk in Communities study. Dietary intake was assessed using a semiquantitative 66-item food frequency questionnaire, and ultra-processed food was classified using the NOVA classification system. Multivariable linear regression models were used to identify the association between 359 metabolites and ultra-processed food consumption. Cox proportional hazards models were used to investigate the prospective association of ultra-processed food–associated metabolites with incident CKD.

Results
Twelve metabolites (saccharine, homostachydrine, stachydrine, N2, N2-dimethylguanosine, catechol sulfate, caffeine, 3-methyl-2-oxovalerate, theobromine, docosahexaenoate, glucose, mannose, and bradykinin) were significantly associated with ultra-processed food consumption after controlling for false discovery rate <0.05 and adjusting for sociodemographic factors, health behaviors, eGFR, and total energy intake. The 12 ultra-processed food–related metabolites significantly improved the prediction of ultra-processed food consumption (difference in C statistics: 0.069, P<1×10−16). Higher levels of mannose, glucose, and N2, N2-dimethylguanosine were associated with higher risk of incident CKD after a median follow-up of 23 years.

Conclusions
We identified 12 serum metabolites associated with ultra-processed food consumption and three of them were positively associated with incident CKD. Mannose and N2, N2-dimethylguanosine are novel markers of CKD that may explain observed associations between ultra-processed food and CKD.

Podcast
This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/CJASN/2023_03_08_CJN0000000000000062.mp3
Kidney Disease Progression in Membranous Nephropathy among Black Participants with High-Risk APOL1 Genotype
Authors: Chen Dhruti P. , Henderson Candace D. , Anguiano Jaeline , Aiello Claudia P. , Collie Mary M. , Moreno Vanessa , Hu Yichun , Hogan Susan L. , Falk Ronald J. ,   on behalf of CureGN
Published: January 2023

Background
Disparity in CKD progression among Black individuals persists in glomerular diseases. Genetic variants in the apolipoprotein L1 (APOL1) gene in the Black population contribute to kidney disease, but the influence in membranous nephropathy remains unknown.

Methods
Longitudinally followed participants enrolled in the Glomerular Disease Collaborative Network or Cure Glomerulonephropathy Network were included if they had DNA or genotyping available for APOL1 (Black participants with membranous nephropathy) or had membranous nephropathy but were not Black. eGFR slopes were estimated using linear mixed-effects models with random effects and adjusting for covariates and interaction terms of covariates. Fisher exact test, Kruskal–Wallis test, and Kaplan–Meier curves with log-rank tests were used to compare groups.

Results
Among 118 Black membranous nephropathy participants, 16 (14%) had high-risk APOL1 genotype (two risk alleles) and 102 (86%) had low-risk APOL1 genotype (zero or one risk alleles, n=53 and n=49, respectively). High-risk APOL1 membranous nephropathy participants were notably younger at disease onset than low-risk APOL1 and membranous nephropathy participants that were not Black (n=572). eGFR at disease onset was not different between groups, although eGFR decline (slope) was steeper in participants with high-risk APOL1 genotype (−16±2 [±SE] ml/min per 1.73 m2 per year) compared with low-risk APOL1 genotype (−4±0.8 ml/min per 1.73 m2 per year) or membranous nephropathy participants that did not identify themselves as Black (−2.0±0.4 ml/min per 1.73 m2 per year) (P<0.0001). Time to kidney failure was faster in the high-risk APOL1 genotype than low-risk APOL1 genotype or membranous nephropathy participants that were not Black.

Conclusions
The prevalence of high-risk APOL1 variant among Black membranous nephropathy participants is comparable with the general Black population (10%–15%), yet the high-risk genotype was associated with worse eGFR decline and faster time to kidney failure compared with low-risk genotype and participants that were not Black.
A POLÍTICA EDUCATIVA PARA MULHERES EM SITUAÇÃO DE CÁRCERE: UM ESTUDO DE CASO NO CONJUTO PENAL NILTON GONÇALVES
Authors: De Andrade Silva Vieira Klyvia Larissa , Da Silva Santana Cristiane 
Published: January 2023

O presente artigo apresenta um recorte de uma pesquisa de trabalho de conclusão de curso, cujo objetivo foi analisar as especificidades de como ocorre a Educação de Jovens e Adultos – EJA – de mulheres que vivem em situação carcerária, bem como as contribuições e limitações do processo educacional para a ressignificação e reinserção na sociedade. Especificamente a pesquisa se propõe a compreender como ocorre a Educação de Jovens e Adultos no sistema penitenciário feminino; apontar as contribuições da EJA no processo de escolarização e reinserção de mulheres que vivem em situação de cárcere; e identificar as dificuldades e limitações encontradas na promoção da aprendizagem escolar no sistema prisional feminino no Conjunto Penal Nilton Gonçalves em Vitória da Conquista–BA. Optamos por uma pesquisa exploratória, de caráter qualitativo na perspectiva de desenvolvermos um estudo de caso. A pesquisa aponta a necessidade de ser estabelecido um processo educacional que contribua para ressignificação e ressocialização da pessoa encarcerada, bem como programas com práticas sócio-educativas que são garantidos por lei, mas que na prática pouco acontecem.
Psychometric analysis of a simplified version of the Emotion Regulation Questionnaire in Mexican adults: The ERQ-CA-9
Authors: Valencia Pablo D. , De la Rosa-Gómez Anabel 
Published: January 2023

Background: The Emotion Regulation Questionnaire (ERQ) is the most widely used measure of cognitive reappraisal and expressive suppression, two core emotion regulation strategies. However, the original ERQ has complex wording, which may make it difficult for readers of lower educational levels. Objective: We aimed to examine the psychometric properties of a simplified version of the ERQ, initially designed for children and adolescents: the ERQ-CA. Method: A sample of 397 Mexican adults was studied (77.3% women, 22.7% men; mean age = 22.84). A confirmatory factor analysis, as well as a graded response model, were used to study the internal functioning of the instrument. In addition, its associations with three psychopathological variables (anxiety, depression, and suicidal ideation) were examined. Results: A 9-item version of the ERQ-CA showed adequate fit (CFI = .95, RMSEA = .06), as well as good reliability (ωreappraisal = .76; ωsuppression = .75). Both subscales performed better at levels closer to the mean of their respective constructs. Finally, significant correlations were found between both subscales and the psychopathological variables. Conclusion: The 9-item ERQ-CA constitutes a promising alternative to measure cognitive reappraisal and expressive suppression in the Mexican adult population.
Sedative effect with the combination of butorphanol and midazolam on two-dimensional shear wave elastography of pancreas and kidney in healthy dogs
Authors: Cho Hyun , Yang Seung Wha , Suh Guk Hyun , Choi Jihye 
Published: January 2023

Abstract

OBJECTIVE
To evaluate the sedative effect of a combination of butorphanol and midazolam on 2-D shear wave elastography (SWE) of the kidneys and pancreas in dogs.

ANIMALS
8 clinically healthy dogs.

PROCEDURES
We conducted a 2-D SWE examination of the bilateral kidneys and the pancreas before and after IV of 0.2 mg/kg butorphanol and 0.1 mg/kg midazolam in each dog. We performed 2-D SWE on the left kidney via a subcostal approach with the dog in right lateral recumbency, on the right kidney via the intercostal approach with the dog in left lateral recumbency, and on the right lobe of the pancreas via the subcostal approach. Subsequently, the pancreas and kidney shear wave velocities (SWV) pre- and postsedation were compared.

RESULTS
On qualitative evaluation using color mapping, the pancreas and kidneys showed a homogeneous blue-to-green color in pre- and post-sedation 2-D SWE. There was no significant difference in SWV pre- and post-sedation in the pancreas and kidneys.

CLINICAL RELEVANCE
Intravenous administration of a combination of 0.2 mg/kg butorphanol and 0.1 mg/kg midazolam did not change the 2-D SWE of the pancreas and kidneys significantly. The combination of butorphanol and midazolam can be used in healthy dogs for 2-D SWE evaluation of the pancreas and kidneys, especially when the patient is uncooperative during the examination.
Research on the evaluation of historical building values based on historic building mapping
Authors: Wu Juan , Lin Hongjian , Yuxi Saizhi 
Published: January 2023

Abstract
Historic buildings carry the history of human civilisation, and their conservation and utilisation are widely valued by countries around the world. At present, the lack of qualitative and quantitative assessment and evaluation methods for the preservation status and attachment value of historic buildings poses a challenge to the smooth implementation of the conservation and utilisation of historic buildings. The development of a set of system standards for the assessment and evaluation of historic buildings is an urgent task for the conservation and utilisation of historic buildings. This paper proposes a set of comprehensive mapping assessment and evaluation system for historical buildings through the analysis and sorting out of the current situation of preserving historical buildings and their development lineage, architectural style, building type, society and art. Finally, based on the above mapping evaluation system, 20 historical buildings are graded according to the requirements of historical building classification, and according to the different levels. Corresponding conservation measures are proposed and different planning schemes are formulated to better utilise the historical, scientific, cultural and economic values of historical buildings.
Extremal trees for the Randić index
Authors: Jahanbani Akbar , Shooshtari Hajar , Shang Yilun 
Published: January 2023

Abstract
Graph theory has applications in various fields due to offering important tools such as topological indices. Among the topological indices, the Randić index is simple and of great importance. The Randić index of a graph 𝒢 can be expressed as

R

(
G
)

=

∑

x
y
∈
Y

(
G
)

1

τ

(
x
)

τ

(
y
)

R\left( G \right) = \sum\nolimits_{xy \in Y\left( G \right)} {{1 \over {\sqrt {\tau \left( x \right)\tau \left( y \right)} }}}

, where 𝒴(𝒢) represents the edge set and τ(x) is the degree of vertex x. In this paper, considering the importance of the Randić index and applications two-trees graphs, we determine the first two minimums among the two-trees graphs.
Three-Point Iterated Interval Half-Cutting for Finding All Local Minima of Unknown Single-Variable Function
Authors: Romanuke Vadim 
Published: January 2023

AbstractA numerical method is suggested to find all local minima and the global minimum of an unknown single-variable function bounded on a given interval regardless of the interval length. The method has six inputs: three inputs defined straightforwardly and three inputs, which are adjustable. The endpoints of the initial interval and a formula for evaluating the single-variable function at any point of this interval are the straightforward inputs. The three adjustable inputs are a tolerance with the minimal and maximal numbers of subintervals. The tolerance is the secondary adjustable input. Having broken the initial interval into a set of subintervals, the three-point iterated half-cutting “gropes” around every local minimum by successively cutting off a half of the subinterval or dividing the subinterval in two. A range of subinterval sets defined by the minimal and maximal numbers of subintervals is covered by running the threepoint half-cutting on every set of subintervals. As a set of values of currently found local minima points changes less than by the tolerance, the set of local minimum points and the respective set of function values at these points are returned. The presented approach is applicable to whichever task of finding local extrema is. If primarily the purpose is to find all local maxima or the global maximum of the function, the presented approach is applied to the function taken with the negative sign. The presented approach is a significant and important contribution to the field of numerical estimation and approximate analysis. Although the method does not assure obtaining all local minima (or maxima) for any function, setting appropriate minimal and maximal numbers of subintervals makes missing some minima (or maxima) very unlikely.
On the Development of Long-Range Water Quality Monitoring System for Outdoor Aquaculture Objects
Authors: Pikulins Dmitrijs , Gotlaufs Roberts , Solovjova Tatjana , Aboltins Arturs , Grizāns Juris , Migla Sandis 
Published: January 2023

Abstract
The paper is dedicated to the development of hardware and software components for the autonomous water quality monitoring system (WQMS) for fishing farms. The system can measure main water quality parameters, storing and processing data on the remote server. The LoRaWAN technological solutions and infrastructure are utilized, providing the optimal tradeoff between data transmission range and adaptive power consumption. The main implementation and exploitation issues are described, and the proposed solutions are provided.