bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRENGTHENING IMPLEMENTATION 5S WORK CULTURE TO FINANCIAL PERFORMANCE AND PRODUCTIVITY AT PT PETROKIMIA GRESIK
Authors: Putri Windy Frecelia , Sriyono  , Setiyono Wisnu Panggah 
Published: August 2023

Introduction: The preliminary, applying Japanese housekeeping, namely the 5S such as Seiri, Seiton, Seiso, Seiketsu, and Shitsuke, is one way to achieve these five qualities. 5S is a procedure that controls and standardizes the workplace by ensuring the efficiency of business processes to provide a safe and high-quality workplace. Aims: This research was a case study that aimed to observe how the 5S was implemented as a work culture and how it influenced organizational performance. Method The research was qualitative research using an ethnography approach through the description of the data collected through field observation. The data analysis included data reduction, data presentation, and drawing conclusions. It was found by observing indicators that activities that needed development were found, such as: Sort Out = 4, Set in Order = 1, Sweep = 1, Standardize = 2 and Sustain = 1. Results Findings show that the previously unfavorable working conditions of employees have now improved and can be further improved by implementing 5Ss. The results show that if the subsidiary has an increase in financial performance, it can be seen from the overall average value of Assets = 0.00103 and the GPM value = 0.547 is higher than before. Conclusion Increased work efficiency and effectiveness are well-coordinated and work quality and safety are well-maintained. Then the financial performance changed greatly, which initially declined due to the weakness of the 5S work culture, has now drastically improved thanks to the 5S work culture that was successfully strengthened.
Multifunctional Properties of BMAP-18 and Its Aliphatic Analogue Against drug-Resistant Bacteria
Authors: Jahan Ishrat , Kumar Dinesh , Shin Song Yub , Lee Chul Won , Shin Sung-Heui , Yang Sungtae 
Published: August 2023

BMAP-18, derived from the N-terminal region of bovine myeloid antimicrobial peptide BMAP-27, demonstrated potent antimicrobial activity without cytotoxicity. This study aimed to compare the antibacterial, antibiofilm, and anti-inflammatory properties of BMAP-18, rich in aromatic phenylalanine residues, with its aliphatic analogue, BMAP-18-FL. Both aromatic BMAP-18 and aliphatic BMAP-18-FL exhibited equally potent antimicrobial activities against Gram-positive and Gram-negative bacteria, particularly methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Pseudomonas aeruginosa (MDRPA). Mechanistic investigations employing SYTOX green uptake, DNA binding, and FACScan analysis revealed that both peptides acted by inducing membrane permeabilization and subsequent intracellular targeting. Moreover, both BMAP-18 and BMAP-18-FL effectively prevented biofilm formation and eradicated existing biofilms of MRSA and MDRPA. Notably, BMAP-18-FL displayed superior anti-inflammatory activity compared to BMAP-18, significantly reducing the expression levels of pro-inflammatory cytokines in lipopolysaccharide-stimulated macrophages. This study emphasizes the similarities and differences in the antimicrobial, antibiofilm, and anti-inflammatory properties between aromatic BMAP-18 and aliphatic BMAP-18-FL, providing valuable insights for the development of multifunctional antimicrobial peptides against drug-resistant bacteria.
Response Surface Methodology in Optimizing the Extraction of Polyphenolic Antioxidants from Flower Buds of <em>Magnolia × soulangeana</em> Soul.-Bod. Var. ‘Lennei’ and Their Detailed Phytochemical Profiling Using Coupled Chromatographic, Spectroscopic and Tandem Mass Spectrometric Techniques
Authors: Zgórka Grażyna , Adamska-Szewczyk Aldona , Baj Tomasz 
Published: August 2023

A novel approach based on response surface methodology (RSM) was developed to predict and apply the best extraction conditions for the isolation of various-type polyphenolic antioxidants from the dried flower buds of Magnolia x soulangeana Soul.-Bod. var. ‘Lennei’ (Magnoliaceae). As a method of choice, ultrasound-assisted extraction was used and the optimized extraction parameters (temperature, time of extraction, the composition of aqueous-ethanolic extractants and solvent to solid ratio) have been determined using a central composite design factorial analysis, followed by appropriate spectrophotometric methods (with Folin–Ciocalteu and 2,2-diphenyl-1-picrylhydrazyl reagents) to determine the antioxidant and antiradical potential of extracts, respectively. The use of 66.8% (V/V) ethanol, as the extraction solvent during the 55.2 min extraction protocol, and the ratio of extractant volume to herbal substance of 46.8 mL/g gave the highest total yield of bioactive antioxidant phenolics in the extract obtained. For this herbal preparation, qualitative and quantitative analysis was performed using combined chromatographic (LC), spectroscopic (PDA) and tandem mass spectrometric (ESI-QTOF–MS/MS) techniques. A detailed phytochemical profiling, conducted for the first time, documented substantial amounts of polyphenolic antioxidants, especially phenylethanoids and flavonoids in the flower buds of M. soulangeana ‘Lennei’. Their average total content exceeded 30.3 and 36.5 mg/g dry weight, respectively.
A Rare Location of Osteosarcoma in the Cuboid Bone
Authors: Dhillon Nireet , Vijayakumar Gayathri , Tepper Sarah C. , Braun Ankica , Blank Alan T. 
Published: August 2023

Case:
In this case report, we describe a patient with left foot pain whose magnetic resonance imaging revealed a destructive tumor of the left cuboid bone. A biopsy of the tumor confirmed an osteoblastic osteosarcoma of the cuboid, and the patient was treated with chemotherapy followed by a below-the-knee amputation.

Conclusion:
There are only a handful of cases reporting osteosarcoma of the cuboid bone, and challenges remain in properly diagnosing the lesion to recommend the best course of treatment.
APVC2021 - Low frequency and broadband vibration and sound radiation reduction of panels from high performance metamaterial damping
Authors: Song Yubao , Chen Shengbing , Zhang Hao , Fan Zhenglei , Peng Qian 
Published: August 2023

Abstract
The low frequency and broadband reduction of vibration and sound from damping treatment is one of the major concerns in research and engineering. In this paper, the combination of artificial metamaterial and damping design is used to improve the reduction effect. The vibration and sound radiation properties of the bare, free layered damping and metamaterial damping panels are compared and studied. Via the comparison of various panels, the vibration and sound radiation reduction and the enhancement from metamaterial damping are analysed. The effects of the material parameters of metamaterial damping elements are studied also. The numerical results indicate that the vibration reduction is significantly improved from the metamaterial damping in quite wide frequency ranges from low to high frequencies; the sound radiation is suppressed effectively also, especially the peaks are reduced obviously. A better reduction effect can be obtained via metamaterial design even with the same added mass as traditional damping treatment, especially, at the middle to low frequencies. The effects from the material parameters of metamaterial damping design are different from those of free layered damping design. And the manipulation and control of the damping effects from metamaterial design will be flexible and easy to realize. Further, an experimental system is built, and the experimental study and verification are carried out. The significant reduction and obvious enhancement from metamaterial damping design are observed from the experimental results.
Assessment of Co-digestion From Poultry Litter and Swine Wastewater and Enrichment Inoculum Effect in Biogas Production
Authors: Somer Juliana Gaio , Luiz Franciele Natividade , Marteres Tiago Joelzer , Meyer Rafaela Faust , Bernal Suzan Prado Fernandes , Passarini Michel Rodrigo Zambrano , Boroski Marcela 
Published: August 2023

Abstract
Lignocellulosic substrate co-digestion as a pre-treatment step to anaerobic digestion increases the viability of using agro-industry waste for biogas production. This study aimed to assess proportions of co-digestion of swine manure and poultry litter for greater methane production, in addition to analyzing the effect of microbial inoculum enrichment on biodigestion. After co-digestions were prepared, the fractions (solid and liquid) were separated, and the liquid was used in the tests. Methane production potential tests were assessed using the Doehlert experimental design in co-digestions of swine manure and poultry litter at 0%, 10%, 20%, 30% and 40% (m/m). The other variable studied was the amount of inoculum added (ISR) at levels of 2, 1.25 and 0.5. The highest methane production values (286–284 NL kgVS-1) were obtained in co-digestions between 10% and 20% (m/m) of poultry litter, which present total solids compatible with using covered lagoon and CSTR model biodigesters. A 34% increase was obtained in the microbial inoculum enrichment study, when compared to standard inoculum use. The co-digestion phase separation procedure developed in this study increased the feasibility of implementing this technology as an alternative to biogas production in commonly used biodigestion systems.
Experiences and perceptions of respectful maternity care during childbirth in health facilities of Eastern province of Rwanda: An Appreciative Inquiry
Authors: Muhayimana Alice , Kearns Irene Josephine , Gishoma Darius , Tengera Olive , Uhawenimana Thierry Claudien 
Published: August 2023

Abstract

Introduction: The World Health Organization (WHO) emphasized the importance of positive childbirth experiences by treating mothers with respect and dignity. Unfortunately, instances of negative childbirth experiences have been documented in several countries,including Rwanda. By examining the best experiences and practices, it becomes possible to discover realistic and culturally accepted sustainable solutions within resource-limited settings such as Rwanda. The objective of this study was to investigate and describe how mothers in the Eastern province of Rwanda perceive and appreciate their own childbirth experiences in relation to RMC.Methods: We employed a qualitative, exploratory, descriptive, and contextual design to examine and describe mothers' positive experiences and perceptions regarding RMC of recent labor and childbirth. The sampling was purposive, focusing on mothers who reported being treated with respect during labor and childbirth in general. A total of 30 mothers were selected from five hospitals in the Eastern Province of Rwanda. To collect the data, we conducted in-depth interviews (IDIs) using questions of the 5D cycle of the Appreciative Inquiry (AI) method. Thematic analysis was employed, and NVivo 12 was utilized to organize the codes and create a codebook.Results: The three main themes and subthemes emerged; 1) Appreciated care encompassed compassionate care and emotional support, autonomy and self-determination, timely care, privacy and confidentiality preservation, and an enabling environment. 2) Perceived greatest care, which focused on respectful care meaning and happiness motives. 3) Suggested strategies, which involved women's self-control, providers' behaviors, and caring leadership.Conclusion: The findings revealed that appreciated care is crucial and integral to the entire birth process. We recommend comprehensive collaboration between services users, healthcare providers (HCPs) and health care management. These measures will help to maintain and reinforce the positive aspects associated with RMC, as reported by the mothers. Furthermore, due to the sensitive nature of RMC, we suggest conducting further studies utilizing the AI approach.
Clinical characteristics and response to abatacept of three Mexican patients with LRBA deficiency
Authors: Eduardo Liquidano-Perez , Ramirez-Ristori Alfonso , Daniela Perez-Perez , Carolina Moreno-Corona Nidia , Eduardo Carrillo-Tapia , Laura Vazquez-Carrillo , Leopoldo Santos-Argumedo , Carlos Rodriguez-Alba Juan , Carlos Bustamante-Ogando Juan , Selma Scheffler-Mendoza , Javier Espinosa-Rosales Francisco , Fabiola Mújica-Guzman , Edith Gonzalez-Serrano Maria , Antonio Yamazaki-Nakashimada Marco , Elva Espinosa-Padilla Sara , Lopez-Herrera Gabriela 
Published: August 2023

Abstract
Purpose. To describe the genetic and clinical characteristics of three patients with LRBA deficiency, an inborn error or immunity that has not been described previously in Latin American patients. Methods. This study included three pediatric patients with recurrent infections, hypogammaglobulinemia, thrombocytopenia, lymphopenia, and pulmonary and gastrointestinal effects. Exome sequencing was performed, variants in LRBA were confirmed by Sanger sequencing, and segregation was investigated to confirm the occurrence of compound heterozygous variants in two patients. LRBA detection in activated PBMCs was performed for all patients, and immunoglobulin levels and cell populations were determined. Clinical records for patients were consulted to determine the type of infection, lung and colon biopsy results and the response to immunosuppressive treatment, including abatacept. Results. Two of the three patients showed an early onset of manifestations. Two patients carried compound heterozygous genetic variants in LRBA, and one patient carried a homozygous variant. Of the five variants identified, three of them were novel and caused a loss of LRBA expression in two of the patients. The three patients presented lung damage and bowel disease. They showed lymphopenia and/or thrombocytopenia. Biopsy sample analysis showed lung or colon damage, and the colon mucosa showed polymorphonuclear infiltrates. Finally, two patients showed partial remission with abatacept; however, the patient with the largest protein truncation did not respond to abatacept treatment. Conclusion. The variants in LRBA reported in this manuscript are novel or were not previously associated with immunodeficiency. The patients whose cases are reported here showed a variable phenotype. The patient with the worst clinical phenotype had the largest protein truncation.
Primary Vs. Staged Repair for Low Anorectal Malformation: Outcome of Two Institutions Experience
Authors: Mirza Abdurrahman , Ullah Irfan , Banoon Elaf , Hakeem Anan , Almaary Jamila , Yousef Yasmin , Bamajboor Abdullah 
Published: August 2023

Abstract

Introduction:
Anorectal malformations (ARM) constitute one of the frequent congenital anomalies which are encountered in pediatric surgery in 1 in 5000 births. The defect affects the normal positioning of the anus, and a corrective surgical procedure is required for repositioning. Rectovestibular fistula is the most common form of ARM that is found in female infants. Posterior sagittal anorectoplasty (PSARP) without colostomy (single-stage) and Posterior sagittal anorectoplasty with colostomy (three-stages) has often been compared as the most feasible interventions to treat both rectovestibular and rectoperineal fistulae. The objective of this study was to assess the result of posterior anorectoplasty with or without diverting colostomy in patients with rectoperineal or rectovestibular fistulae.
Methodology:
A retrospective cohort study was undertaken to examine the post-operative outcomes of single-stage and three-stages PSARP on infants with rectovestibular and rectoperineal fistulae in Riyadh and Jeddah regions of Saudi Arabia. After ethical approvals from King Abdullah International Medical Research Centre, the study reviewed patient files from National Guard hospitals from the two regions.
Results:
Out of the 50 patients studied, 80% were females, while 20% were males. The most typical type of fistula was rectovestibular, which accounted for 54%, while rectoperineal accounted for 46%. PSARP without colostomy (single-stage) was the most common intervention. Major complications reported after the operations were constipation (44%), soiling (10%), wound infection (6%) and dehiscence (6%).
Conclusion:
The one-stage PSARP without colostomy has been identified as the feasible, safe, cost-effective surgical procedure to be used on ARM infants.
Establishment of the microstructure of porous materials and its relationship with effective mechanical properties
Authors: Chen Kangni , Qin Hongling , Ren Zhiying 
Published: August 2023

Abstract

In this study, a porous structure for a porous liquid storage medium is generated, and the homogenization theory based on displacement boundary conditions is used to predict the effective mechanical properties. The relationship between the porous material's macroscopic mechanical properties and microstructure is next analyzed. In order to establish the relationship between the microstructure of porous materials and their macroscopic mechanical properties, assuming that the pores grow along the z direction, a method is proposed to generate 3D open-cell porous materials based on six design parameters (i.e., the number of pores, porosity, irregularity of pore distribution, the randomness of pore growth in the x and y directions, and randomness of pore size). Since the porosity of oil-bearing materials ranges from 20–30%, the porosity of the RVE (Representative Volume Element) was kept under control at about 25%, and the effect of the six design factors on the mechanical properties of the RVE was investigated. Utilizing SLA 3D printing technology, specimens were produced, and compression tests were used to show how useful the results of the numerical analysis were. The results demonstrated that the mechanical properties of the models generated with the identical design parameters are similar whenever the number of RVE pores reaches 16 and the irregularity of the pore distribution reaches 0.25. The mechanical properties of porous materials simultaneously decrease in the z direction and increase in the x and y directions as the randomness of pore growth increases. Pore size randomness has a similar effect on RVE as pore growth randomness. However, the pore size's randomization can lead to instability in the RVE's porosity, which can lead to unstable mechanical properties. The mechanical properties of RVE are simultaneously affected by the design parameters, which are superimposed.
All dielectric highly efficient achromatic meta-lens using inverse Design Optimization
Authors: Maher Abdullah , Swillam Mohamed A. 
Published: August 2023

Abstract
This work presents a high-efficiency achromatic meta-lens based on inverse design with topology optimization methodology. The meta-lens design with high numerical aperture values (NA = 0.7, NA = 0.8, and NA = 0.9) along the visible band starts from 450 nm to 800 nm. The final optimized structures for the three conditions of the high numerical apertures have high focusing efficiency along the design band. The optimization problem is based on Kreisselmeier–Steinhauser (k-s) objective function, leading to approximately stable response over the broadband bandwidths of the three designs.
Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence
Authors: Wu Linxu , Zhu Xinglin , Luo Cai , Zhao Yangyang , Pan Shanshan , Shi Kaijia , Shen Zhihua , Guo Junli , Jie Wei 
Published: August 2023

Abstract

Objective: Hyperinflammatory responses are pivotal in the pathophysiology of cardiomyocyte senescence, with IL33 serving as a crucial pro-inflammatory mediator. Our previous findings highlighted RND3's suppressive effect on IL33 expression. This study delves into the influence of RND3 on IL33/ST2 signaling activation and cardiomyocyte senescence.
METHODS: AC16 cardiomyocytes were subjected to treatments involving recombinant IL33, NF-κB inhibitor PDTC, or ST2 antibody Astegolimab. SA-β-gal and γH2AX staining were utilized to monitor alterations in cell senescence and DNA damage, respectively. Western blot analysis was conducted to ascertain the expression of Senescence-Associated Secretory Phenotype (SASP) and NF-κB activation. Utilizing CRISPR/Cas9 technology, the RND3 gene was knocked out in H9C2 cells, followed by senescence analysis and sST2 level detection in the culture medium supernatant via ELISA. Post-AAV9 injection overexpressing RND3in SD rats, IL33/ST2 and SASP expression in heart tissues, and serum IL33 and sST2 changes were evaluated using ELISA.
RESULTS: Exogenous IL-33 significantly induced IL-1α, IL6, and MCP1 expression, increased the p-p65/p65 ratio, and the proportion of SA-β-gal and γH2AX positive cells in AC16 cells. PDTC and Astegolimab application mitigated these effects. RND3 knockout in H9C2 cells led to increased intracellular IL33, ST2L, IL1 α, IL6, and MCP1 expression, decreased sST2 in the supernatant, and increased SA-β-gal and γH2AX positive cells. RND3 overexpression suppressed IL33, ST2L, IL-1α, IL6, and MCP1 expression in heart tissues, decreased serum IL33, and increased sST2 levels.
CONCLUSION: RND3 expression in cardiomyocytes modulates cell senescence by negatively regulating the IL33/ST2/NF-κB signaling pathway, underscoring its potential as a therapeutic target in cardiovascular senescence.
Biological treatment with co-inoculation of Pseudomonas fluorescens and Trichoderma viride as effective method for degradation of chlorpyrifos in soil
Authors: Arya P. R. , Binitha N. K , Unnikrishnan Boby Vattekkattu 
Published: August 2023

Abstract

A study conducted to understand chlorpyrifos degradation revealed that content of chlorpyrifos was reduced by 34.76% within 60 days of incubation under natural conditions. Effect of physical, chemical and biological treatments on fastening the process of chlorpyrifos degradation was evaluated, which revealed that biological treatment with microbial inoculants (combination of Pseudomonas fluorescens and Trichoderma viride) recorded maximum degradation (74.99%) followed by single application of Pseudomonas fluorescens (69.94%) and Trichoderma viride (66.35%) on 60 days of incubation. Soil enzymes: dehydrogenase, phosphatase and urease showed significantly higher activities in treatments with Pseudomonas fluorescens and Trichoderma viride either single or combination on comparison with control. Microbial biomass carbon increased to 99.16 µg g− 1 in treatment receiving combination of Pseudomonas fluorescens and Trichoderma viride while control recorded only 83.77 µg g− 1. Co-inoculation of Pseudomonas fluorescens and Trichoderma viride resulted in faster degradation of chlorpyrifos without affecting the chemical and biological properties of soil.