bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative Fibrinogen Predicting the Occurrence of Ovarian Torsion in Children
Authors: Shen Qiyang , Zhang Lijie , Liu Xingyu , Han Qi , Zhou Kai , Li Tao , Zhou Jianfeng 
Published: September 2023

Abstract
Background: Ovarian torsion (OT) is a rare occurrence in the pediatric population, characterized by a wide range of clinical manifestations, and a delayed diagnosis can have a profound impact on fertility. Although lower abdominal pain, nausea, and vomiting are commonly associated with OT, these presentations are predominantly atypical. Moreover, diagnosing OT in children poses a significant challenge due to the often unreliable expression of symptoms in this population. It is imperative to analyze the clinical characteristics of OT in children and adolescents and identify specific indicators in order to enhance the promptness and precision of preoperative OT diagnosis.
Methods: Our study encompassed all female individuals (<18 years old) who were suspected of OT and underwent surgical intervention from August 2006 to February 2023. Pertinent clinical and laboratory information was gathered from the patients, and subsequently, they were categorized into two groups based on the presence or absence of torsion. We conducted univariate significance analysis, multivariate logistic regression analysis, and receiver operating characteristic (ROC) curves to ascertain autonomous factors that could forecast OT in pediatric patients.
Result: The findings revealed that OT transpired in 160 (33.6%) out of the 475 female subjects included in our study. Univariate and multivariable logistic regression analysis of the gathered data revealed three risk factors that were significantly linked to OT : Body temperature [1.5464 (1.3838, 1.7283), P = 1.5099e-14]; AFR [1.2238 (1.0857, 1.3795), P = 0.0009]; Fibrinogen [4.4145 (2.1538, 9.048), P = 0.0001]. The effectiveness of the three independent impact factors was examined using ROC curves. The result is body temperature (ROC 1, AUC = 0.6108, CI: 0.5487-0.6729), AFR (ROC 2, AUC = 0.5794, CI: 0.5132-0.6456) and fibrinogen (ROC 3, AUC = 0.7306, CI: 0.6649-0.7962). The area under the curve of the three independent predictors were compared to determine whether there was a difference in predictive efficacy. The results showed that the predictive efficacy of fibrinogen was significantly higher than that of body temperature and AFR (ROC1/ROC2: P = 0.4571>0.05, ROC1/ROC3: P = 0.6408>0.05, ROC2/ROC3: P = 0.0002<0.05).
Conclusions: Our study suggests that fibrinogen can be an independent predictor of OT in girls.
Machine learning-based identification of ferroptosis-related biomarkers in osteoarthritis
Authors: Jin Yingchao , Zhang Hua 
Published: September 2023

Abstract
Background
Osteoarthritis (OA) is the most common joint disease and a major cause of chronic disability in elderly individuals. OA is characterized by degeneration of articular cartilage, structural changes in the subchondral bone structure, and formation of bony encumbrances, with the main clinical manifestations being joint swelling, pain, stiffness, deformity, and limited mobility. Ferroptosis is a newly identified form of lipid peroxidation-induced cell death. In recent years, several studies have shown that the pathological process of OA is related to ferroptosis.
Objective
The focus of this work was to identify and validate ferroptosis-related genes (FRGs) differentially expressed in osteoarthritis patients and to investigate potential molecular mechanisms.
Methods
The GSE98918 data were downloaded from the GEO database as the training set, and the GSE51588 data were used as the validation set. The differential gene expression of the training set was analyzed using R software and the ferroptosis-related differentially expressed genes. Then, machine learning algorithms were applied to build LASSO regression models and support vector machine models. After that, their intersection genes were used as feature genes to draw receiver operator characteristic (ROC) curves, and the resulting feature genes were validated using the validation set. In addition, the expression profiles of osteoarthritis were analyzed by immune cell infiltration, and the co-expression correlation between the characterized genes and immune cells was constructed.
CONCLUSION
KLF2 and DAZAP1 may serve as potential diagnostic biomarkers for OA. Meanwhile, KLF2 and DAZAP1 may be ferroptosis-related in OA, which provides insights for the development of new therapeutic approaches for OA.
Effect of ultrasound and enzymatic hydrolysis on the physicochemical and functional properties of different galactomannan gums
Authors: Busch Veronica , Pepa Lorena , Buera Pilar , Pannizzolo Luis , Ferreira Fernando 
Published: September 2023

Abstract
Galactomannans are polysaccharides commonly extracted from the endosperm of various leguminous seeds, exhibiting variations in their man/gal ratio based on their botanical origin. These gums are highly valued for their biodegradability and excellent stability. However, their applications have been limited due to their high viscosity and molecular weight. In this study, we explore the enzymatic and ultrasound depolymerization of galactomannans, resulting in the production of freeze-dried hydrolysates that are subsequently characterized. The hydrolysis process leads to a decrease in viscosity and molecular weight, accompanied by a noticeable increase in polydispersity through enzymatic treatment. Thin-layer chromatography (TLC) analysis indicates the generation of subunits consisting of nine or eight members. Fourier-transform infrared (FTIR) spectroscopy analysis demonstrates no significant changes in functional groups following ultrasound hydrolysis. Furthermore, consistent with the TLC results, the hydrolysates display reactivity towards non-enzymatic browning (NEB), yielding intermediate products with limited browning development.This study expands, diversifies, and enhances the potential applications of these galactomannans in the pharmaceutical, cosmetic, and food industries.
Association between trabecular bone score and type 1 diabetes: A meta-analysis of cross-sectional study
Authors: Pan Runzhou , Zhang Yan , Zhao Yongcai 
Published: September 2023

Abstract
Background: Bone fragility is a recognized complication of Type 1 diabetes(T1D). Thus, lower trabecular bone score(TBS) measurements in T1D patients can be predicted. However, the results of current studies on TBS in patients with T1D are inconsistent. In this context, the present study aimed to test the hypothesis that T1D is associated with lower TBS through a meta-analysis.
Methods: An electronic search of the literature was conducted using PubMed, Embase and Web of science databases to identify studies related to TBS and T1D, supplemented by an additional manual check of the reference list of relevant original and review articles. All data was analyzed using a random effects model. Results were compared using standardized mean differences (SMD) and 95% confidence intervals (CI). P≤0.05 was considered statistically significant. Review Manager 5.4 software and Stata 17.0 software were used for statistical analysis.
Results: Seven cross-sectional studies involving 848 participants were included. TBS was lower in T1D patients than in healthy controls on random effects analysis, with no heterogeneity(SMD =-0.39, 95%CI [-0.53, -0.24], P < 0.001; I2=0%). In addition, by subgroup analysis, T1D patients were strongly associated with reduced TBS in different regions and age groups, and the results were independent of covariate adjustment.
Conclusion: This study showed that TBS was lower in patients with T1D than in healthy individuals with normal blood glucose levels, suggesting that TBS may be a useful measure to assess fracture risk in T1D.
Investigating flight ability and dispersal distance of Cydia pomonella moth in northeast China to assess the side effects of X-ray Irradiation
Authors: Huang Sheng-Wang , Zhang Jing-Han , Wei Zi-Han , Yang Xian-Ming , Wang Xing-Ya , Yang Xue-Qing 
Published: September 2023

Abstract
The codling moth Cydia pomonella (L.) is a highly destructive pest that causes considerable damage to pome fruits and walnuts worldwide. In Canada, the sterile insect technique (SIT) has proven to be an effective method for controlling C. pomonella population. However, the sterilization process, which involves exposing male moths to gamma radiation or X-rays, may result in a decrease in their mating competitiveness, likely due to a decline in their flight capacity. The impact of X-ray irradiation on the flight ability of sterilized male C. pomonella remains uncertain. In this study, we first examined the flight rhythm of male and female adults of C. pomonella. The findings revealed a significant variations in the average flight speed of both male and female moths at different stages of maturity, with females exhibiting longer flight durations and distances. Since male moths are primarily utilized in SIT programs, we focused on assessing the effect of irradiation on the flight performance of 3-day-old male moths, as they demonstrated the longest flight distance. The results indicated a significant decrease in flight performance, including flight distance, duration, and average speed, among males exposed to radiation at a dose from 183 Gy to 366 Gy. Moreover, an irradiation dose of 366 Gy caused wing deformities, limiting the dispersal distance of moths in orchards according to the mark-and-recapture assay. Further quantitative reverse-transcription PCR (RT-qPCR) analysis revealed down-regulation of flight-related genes such as flightin, myosin heavy chain, and distal-lessfollowing radiation exposure. Taken together, these findings demonstrate that X-ray irradiation at a radiation dose higher than 183 Gy adversely affects the flight ability of male C. pomonella adults. These insights not only enhance our understanding of how radiation sterilization diminishes the mating competitiveness of male moths but also contribute to the development and improvement of SIT practices for the effective control of C. pomonella.
Clinical Significance of Perioperative Hyperglycemia in Radical Gastrectomy Among Non- diabetic Patients: Evidence for Better Perioperative Glucose Management in Different Anastomotic Methods
Authors: Yu Zhiqiang , Mei Dianfeng , Mao Chenchen , Jiang Zhixuan , Shao Jiancan , Cai Wentao , Zheng Jingwei , Zhu Shanli , Xue Xiangyang , Shen Xian 
Published: September 2023

Abstract
Background: Uncontrolled perioperative hyperglycemia (HG) in patients undergoing surgery was determined as a risk factor for postoperative complications. Few studies have focused on the effects of HG in gastric cancer patients undergoing different anastomotic methods after radical gastrectomy.
Methods:
We performed a double-institutional dataset study involving 811 patients who had undergone radical gastrectomy between 2014 and 2017. Patients with diabetes mellitus were excluded. Propensity-score-matching (PSM) analysis was performed to strictly balance the significant variables. The association between any elevated perioperative glucose value (HG≥7 mmol/L) and postoperative complications in patients treated with different anastomotic methods was assessed.
Results: Among the 742 non-diabetic patients with gastric cancer, 100 (13.48%) and 148 (19.95%) experienced preoperative and postoperative HG, respectively. Perioperative HG was not significantly associated with postoperative complications. On comparing the different anastomotic methods, differences in postoperative complication incidence were exclusively identified between postoperative hypoglycemia and HG (20.32% vs. 34.62%, P=0.025) among patients underwent Billroth-I anastomosis. Further logistic regressive analysis found HG to be independently associated with postoperative complications before (odds ratio [OR]:1.989, 95% confidence interval [CI]:1.031–3.837, P=0.040) and after (OR:3.341, 95%CI: 1.153–9.685, P=0.026) PSM. Finally, preoperative HG remained a significant predictor of postoperative HG (OR:3.718, 95%CI: 1.673–8.260, P=0.001).
Conclusions: Postoperative HG, rather than preoperative HG, was significantly associated with worse postoperative outcomes in non-diabetic patients who underwent Billroth-I anastomosis after radical gastrectomy. However, preoperative HG was associated with postoperative HG, suggesting that improved preoperative glycemic management may help reduce postoperative hyperglycemic events.
Electrical impedance myography detects dystrophin-related muscle changes in mdx mice
Authors: Hiyoshi Tetsuaki , Zhao Fuqiang , Baba Rina , Hirakawa Takeshi , Kuboki Ryosuke , Suzuki Kazunori , Tomimatsu Yoshiro , O’Donnell Patricio , Han Steve , Zach Neta , Nakashima Masato 
Published: September 2023

Abstract
Background
The lack of functional dystrophin protein in Duchenne muscular dystrophy (DMD) causes chronic skeletal muscle inflammation and degeneration. Therefore, the restoration of functional dystrophin levels is a fundamental approach for DMD therapy. Electrical impedance myography (EIM) is an emerging tool that provides noninvasive monitoring of muscle conditions and has been suggested as a treatment response biomarker in diverse indications. Although magnetic resonance imaging (MRI) of skeletal muscles has become a standard measurement in clinical trials for DMD, EIM offers distinct advantages, such as portability, user-friendliness, and reduced cost, allowing for remote monitoring of disease progression or response to therapy. To investigate the potential of EIM as a biomarker for DMD, we compared longitudinal EIM data with MRI/histopathological data from an X-linked muscular dystrophy (mdx) mouse model of DMD. In addition, we investigated whether EIM could detect dystrophin-related changes in muscles using antisense-mediated exon skipping in mdx mice.
Methods
Longitudinal MRI/ magnetic resonance spectroscopy (MRS) data of muscle T2 and fat, and three EIM parameters with histopathology were obtained from the hindlimb muscles of wild-type (WT) and mdx mice. In the EIM study, a cell-penetrating peptide (Pip9b2) conjugated antisense phosphorodiamidate morpholino oligomer (PPMO), designed to induce exon-skipping and restore functional dystrophin production, was administered intravenously to mdx mice.
Results
MRI imaging in mdx mice showed higher T2 intensity at 6 weeks of age in hindlimb muscles compared to WT mice, which decreased at ≥ 9 weeks of age. In contrast, EIM reactance began to decline at 12 weeks of age, with peak reduction at 18 weeks of age in mdx mice. This decline was associated with myofiber atrophy and connective tissue infiltration in the skeletal muscles. Repeated dosing of PPMO (10 mg/kg, 4 times every 2 weeks) in mdx mice led to an increase in muscular dystrophin protein and reversed the decrease in EIM reactance.
Conclusions
These findings suggest that muscle T2 MRI is sensitive to the early inflammatory response associated with dystrophin deficiency, whereas EIM provides a valuable biomarker for the noninvasive monitoring of subsequent changes in skeletal muscle composition. Furthermore, EIM reactance has the potential to monitor dystrophin-deficient muscle abnormalities and their recovery in response to antisense-mediated exon skipping.
Analysis of the efficacy of triple-channel minimally invasive knee arthroscopy in the treatment of popliteal cysts in children
Authors: He Shan , Yang Qining , Kang Jiayu , Zhou Yongwei 
Published: September 2023

Abstract
Background
The purpose of this study was to describe a technique for the treatment of pediatric popliteal cysts with a triple-channel knee arthroscopic approach, with the hypothesis that this technique has good clinical outcomes and a low recurrence rate.
Methods
Retrospective analysis of 14 patients with symptomatic pediatric popliteal cysts treated at our joint surgery center using this minimally invasive technique from December 2017 to December 2020. Arthroscopy was used to adequately enlarge the posterior medial flap opening between the cyst and the joint cavity, and to completely resect the cyst wall. The recurrence of popliteal cysts was examined by MRI at 3 and 12 months after surgery, respectively, and the Rauschning and Lindgren scores were recorded to evaluate the clinical outcome.
Results
A total of 14 children completed the follow-up, including 8 boys and 6 girls, with a mean age of 9.9 ± 1.1 years (5–12 years); 5 cases in the left knee and 9 cases in the right knee; the mean operative time was 19.2 ± 2.7 min (10–25 min); the mean follow-up time was 15.1 ± 2.4 months (12–24 months) There was no intraoperative vascular nerve injury and no incisional exudate infection There was no intraoperative vascular nerve injury and no incisional fluid infection. Postoperative symptoms of the posterior knee disappeared in the children, Rauschning and Lindgren scores improved significantly postoperatively, and no signs of recurrence were found on MRI in all cases.
Conclusions
This study concluded that the use of arthroscopic three-channel minimally invasive technique for the treatment of popliteal cysts in children is effective and safe, and is worthy of clinical promotion.
3- Way coupled urban flood modelling for a part of Chennai City using high-resolution topographic data
Authors: Pradeep C. , Sankar C. P , Thirumalaivasan D. , Kumar K Ajith , Kathiravan K. , Vidyasakar A. , Arunbharathi V. 
Published: September 2023

Abstract
The catastrophic flood events which caused severe damage to life and property over the Chennai region in 2005 and 2015 are considered in this study. The flood inundation extent and flood depth of this events were simulated using a 3-way coupling with MIKE FLOOD. It couples three hydrodynamic models namely MIKE 11 HD, MIKE URBAN (MOUSE), and MIKE 21, which can simulate all the sources of the flood, i.e., riverine, urban and surface runoff. HEC-HMS is used for performing hydrologic simulations. High-resolution LiDAR DEM acquired through Airborne Laser Scanning technology is used for extraction of cross section of rivers, ground level of manholes for stormwater drains and for preparing accurate bathymetry for use in MIKE 21. Flood depths were measured in widespread floodplains of Adyar River after the flood events of 2005 and 2015. Model results are validated with the measured flood depths, performance indices show (R2=0.772 for 2005 and R2=0.883 for 2015) good agreement between them. This study can be used as an effective tool for flood management and flood damage assessments.
Trait discovery for yield, related attributes and quality parameters and identification of potential stable donors for genetic improvement of groundnuts through evaluation of germplasm originated from different countries in two contrasting environments
Authors: Rani Kirti , BC Ajay , Bera Sandip Kumar , Mahatma Mahesh Kumar , Singh Sushmita , K Gangadhara , AL Rathnakumar , Kona Praveen , Kumar Narendra , GA Rajanna 
Published: September 2023

Abstract
The study aimed to analyze a varied collection of 371 germplasm obtained from various countries, with regards to yield-related characteristics, oil, protein, sugar, free amino acids, and total phenolics, in two distinct environments. The purpose was to assess the extent of inherent genotypic diversity and the potential for improving productivity and quality through breeding. The study identified germplasm that exhibited superior and stable performance with two or more desirable traits. Specifically, NRCGs-10366, 10480, 10485, and 10844 were found to be superior in terms of yield (PY), hundred kernel weight (HKW), and seed shape (SHP). NRCG-11390 was identified as superior for yield (PY), protein content, and sugar content. Additionally, NRCGs-12469, 14089, and 16492 were found to be superior for important biochemical traits such as oil, protein, and sugar content. NRCG-11101 was identified as superior for HKW, protein content, and oil content, while NRCGs-11154 and 11164 were found to be superior for HKW, protein content, and sugar content. The study has identified germplasm with a grain protein content exceeding 34% and an oil content ranging from 47% to 48%. Germplasm exhibiting specific traits were identified for their potential utilisation as donors in the groundnut improvement program. The Spanish collection presents a potential source of valuable breeding traits for enhancing groundnut productivity and improving the content of oil, protein, sugar, phenol, and FAA, in various combinations.
Die Eventmarke - eine Marke wie jede andere?
Authors: Brauchbar Birkhäuser Simone , Zingg Olivia 
Published: September 2023

Aufgrund eines Rechtsstreits zwischen FIFA und PUMA hatte sich das Bundesgericht im April 2022 mit der Thematik von Eventmarken zu befassen und über die Kernproblematik derer Eintragungsfähigkeit zu befinden. Das Bundesgericht entschied in einem richtungsweisen-den Urteil, dass die Marken «QATAR 2022» (fig.) und «WORLD CUP 2022» (fig.) einen rein deskriptiven Charakter aufweisen würden und dem Markenschutz deshalb nicht zugänglich seien. Weiter qualifizierte es die Zeichen «PUMA WORLD CUP QATAR 2022» und «PUMA WORLD CUP 2022» als irreführend und damit als nicht eintragungsfähig. Gestützt auf dieses Urteil passte das IGE seine Praxis in Bezug auf das Prüfen der Unterscheidungs-kraft von Eventmarken per 1. Juli 2023 an. Der vorliegende Aufsatz ordnet den Entscheid des Bundesgerichts in den grösseren Kontext des Eventmarkenrechts ein und zeigt unter ande-rem auf, welche Rolle das Lauterkeitsrecht in solchen Konstellationen spielen kann.
--
À la suite d’un litige opposant la FIFA et PUMA, le Tribunal fédéral s’est penché en avril 2022 sur la thématique des marques événementielles et s’est prononcé sur la question centrale de leur enregistrement. Dans un arrêt qui fera date, la Haute Cour a décidé que les marques "QATAR 2022" (fig.) et "WORLD CUP 2022" (fig.) présentaient un caractère purement descriptif et ne bénéficiaient ainsi pas de la protection des marques. En outre, elle a considéré que les signes "PUMA WORLD CUP QATAR 2022" et "PUMA WORLD CUP 2022" étaient trompeurs et ne pouvaient être enregistrés. Sur la base de cet arrêt, l'IPI a décidé d’adapter sa pratique d'examen concernant l'analyse du caractère distinctif des marques événementielles à partir du 1er juillet 2023. Le présent article replace la décision du Tribunal fédéral dans le contexte plus général du droit des marques événementielles et montre en particulier le rôle qu’est susceptible de jouer le droit de la concurrence déloyale dans de telles constellations. Le présent article replace la décision du Tribunal fédéral dans le contexte plus général du droit des marques événementielles et montre en particulier le rôle que le droit de la concurrence peut jouer dans de telles constellations.