bluuebunny/crossref_metadata_2025_split huggingface dataset:
How do Psychological distress and social support associate with health-related quality of life in pregnant women? The mediating role of self-compassion, resilience and emotion regulation
Authors: Afrashteh Majid Yousefi , Masoumi Samin 
Published: August 2023

Abstract
Background Although there are the plenty of clinical data available during COVID-19 pandemic, rare researches on the health-related quality of life of pregnant women have been published. We therefore investigate the extent to which self-compassion, resilience and emotion regulation mediate the association between psychological distress and social support with health-related quality of life in pregnant women during Covid-19 pandemic.Method A cross-sectional study design was engaged. Participants were recruited from health service centers of Hamadan, Iran. Data was collected from 370 pregnant women. Participants completed self-report measures. SPSS-26 software was used for descriptive statistics and correlation matrix, and LISREL-10.20 software was used to path analysis and determine the relationships between variables within the model.Results Correlational analyses revealed that the correlation coefficient of quality of life with psychological distress was − 0.45, with social support was 0.36, with self-compassion was 0.50, with resilience was 0.47 and with emotion regulation was − 0.50. All these coefficients are significant at the level of 0.001. Psychological distress has an indirect effect (β = -0.20) on women's quality of life through the three mediating variables of resilience, self-compassion and emotion regulation. Social support also has an indirect effect (β = 0.14) on women's quality of life through three mediators.Conclusion These findings help a better understanding of the psychological impact of the pandemic on the studied group as a crucial step in guiding policies and interventions to maintain their health-related quality of life.
Synthesis of PANI@α-Fe2O3 /Al2O3 photo-Fenton composite for the enhanced efficient methylene blue removal
Authors: Yan Su , Liang Xiaoping , Liu Shiwei , Zhang Yinan , Zeng Jing , Bai Jinshuo , Zhu Xueli , Li Jianxin 
Published: August 2023

Abstract
In this work, β-FeOOH precursors were grown on flat Al2O3 ceramic matrix by a hydrothermal-assisted sol-gel composite method, followed by heat treatment to obtain α-Fe2O3/Al2O3 photo-Fenton catalysts. The effect of heat treatment temperature on the microstructure and photo-Fenton performance of α-Fe2O3/Al2O3 photo-Fenton catalysts was studied emphatically. The PANI@α-Fe2O3/Al2O3 photo-Fenton composite (PFA-550) were obtained by coating polyaniline (PANI) on the optimized α-Fe2O3/Al2O3 (FA-550) surface via in-situ polymerization, and subsequently used as an anode to assemble a photo-Fenton reactor for the removal of methylene blue (MB). The effect of pH value and applied electric field on MB removal of the photo-Fenton reactor was investigated. It was shown that α-Fe2O3 nanotubes was uniformly distributed over the surface of the flat Al2O3 ceramic in the FA-550 heated at 550°C, which exhibited high photo-Fenton activity. Compared to FA-550, PFA-550 exhibit superior photo-Fenton activity. In addition, PFA-550 have excellent photo-Fenton activity in a wide pH range (pH=3.92~9.21) rather than narrow range (pH=2.0~3.5) in conventional Fenton reaction. The migration of photogenerated electrons(e-) were promoted by external electric field from the surface of PFA-550 to the counter electrode. The removal rate of MB was substantially increased with the effective improvement of the separation of photogenerated e--h+.
Fabrication of MOF(Fe)/FeS x composite as efficient photocatalyst for degradation of rhodamine B
Authors: Pan Junjie , Chen Zhengdao , Zhou Junmei , Luo Qing 
Published: August 2023

Abstract
With the development of science and technology, the living standards of human beings have been greatly improved. However, the rapid development of society caused serious environmental pollution issues, especially coming from the organic materials. In this paper, MOF(Fe)/FeSx composite were successfully fabricated via solvothermal method by adopting MOF(Fe) as template and thioacetamide as sulfur source, and its photocatalytic activity was evaluated by degradation of rhodamine B (RhB) under UV light irradiation. The influence of thioacetamide on the photocatalytic activity of MOF(Fe)/FeSx composite was explored. The results shown that MOF(Fe)/FeSx(2) exhibited the optimal photocatalytic degradation performance. After 35 min UV irradiation, MOF(Fe)/FeSx(2) could degrade 97.19% of rhodamine B (RhB). The excellent photocatalytic degradation performance of MOF(Fe)/FeSx(2) made it potential to be used for the degradation of organic pollutants produced in factories and daily life.
Study on significant role of Ru on MWCNT supported PtRu electrocatalysts for Ethanol Electro-Oxidation
Authors: Singh Susmita , Ghosh Moupiya , Bose Mainak , Saha Sinthia , Dutta Anushna 
Published: August 2023

Abstract
The composition and atomic structure of nanoalloy catalysts in the Ethanol Oxidation Reaction (EOR) play an important role. To study this and develop an electrochemically active catalyst towards ethanol electro-oxidation, a second oxophilic metal has generally been initiated as an alloy, capable of enhancing the electrocatalytic activity of Platinum. In view of the above, the present investigation deals with nano particles of PtRu with different bimetallic compositions supported on Multiwalled Carbon Nano Tube (MWCNT) for their activity on the Ethanol electro-oxidation. The structure, morphology and bonding of the catalysts were studied by X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy-Dispersive X-Ray Fluorescence (EDXRF) and Fourier-Transform Infrared spectroscopy (FTIR). Electrochemical methods like Cyclic Voltammetry (CV), Linear Sweep Voltammetry (LSV) and Chronoamperometry (CA) were used to explore the catalytic activity towards Ethanol electro-oxidation. This study focused on establishing the relationship between the catalysts’ composition, atomic structure and catalytic activity for the EOR. All the results of physical and electrochemical studies revealed an intriguing composition-structure-activity relationship for the PtRu electrocatalysts under EOR experimental conditions. In particular, the alloy with a Pt/Ru ratio of ∼84:16 was found to exhibit a maximum EOR activity as a function of the bimetallic composition. Notably, the catalytic activities of the C/PtRu electrocatalysts showed a significant improvement during the EOR. The results show some new light on the composition of C/PtRu catalysts regarding ethanol oxidation reaction which is important for the rational design and synthesis of active nanoalloy catalysts for Direct Ethanol Fuel Cell (DEFC).
Improving fusion call confidence and reliability through an optimized process in low quality RNA from formalin-fixed, paraffin-embedded samples
Authors: Liang Qingchun , Zhou Peng , Li Namei , Tan Hong , Lu Junmi , Ni Yang , Ling Yuan , Lin Lin , Su Chunxue , Zhang Chao , Deng Wanglong , Xu Qing , Sun Yi 
Published: August 2023

Abstract
Identifying fusion genes in solid tumors is crucial for precision diagnosis and treatment of cancer patients. However, poor RNA quality may pose a major challenge to the reliability of fusion detection. In this study, an optimized RNA fusion detection method using targeted next-generation sequencing was developed and validated to detect gene fusions in solid tumors using formalin-fixed, paraffin-embedded (FFPE) samples, where the RNA quality standard DV200 was as low as 20%. Uniquely designed probes that target the fusion junction sequences enhances the detection and realism of classical fusions. Gene fusions in five low-quality RNA samples could only be detected using the designed probe. Archived 104 tumor samples harboring gene fusion were divided into four groups according to RNA quality (DV200) and fusion detection methods. Based on the optimized library construction process, specific probe and bioinformatics analysis process, the RNA fusion panel identified the same gene fusions compared with the DNA level in 14 (100%, group A, DV200 ≥ 40%), 34 (82.9%, group B, DV200 ≥ 40%), 22 (81.5%, group C, 20% ≤DV200 < 40%) and 5 (71.4%, group D, DV200 < 20%) samples, respectively. Taken together, the optimization of the experimental procedure improves the detection of gene fusion in low-quality RNA samples and also contributes to accurate diagnosis and treatment.
Comparative Study of Posaconazole and Voriconazole for Primary Antifungal Prophylaxis in Patients with Pediatric Acute Leukemia
Authors: Tu Songji , zhangkunlong 张坤龙 , Wang Ningling , Chu Jinhua , Yang Linhai , Xie Zhiwei 
Published: August 2023

Abstract
Background
Posaconazole and voriconazole are commonly used for preventing invasive fungal disease (IFD), but few studies compared posaconazole with voriconazole for primary antifungal prophylaxis (PAP) in pediatric acute leukemia.
Objective
To compare posaconazole with voriconazole for PAP in pediatric acute leukemia.
Methods
This retrospective observational study enrolled pediatric patients with non-M3 acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) between December 2017 and November 2019 in the Second Affiliated Hospital of Anhui Medical University. The patients received voriconazole or posaconazole for PAP. The primary outcome was the breakthrough of IFD. The secondary outcome was the overall survival (OS) and IFD-free survival of patients.
Results
A total of the 275 patients were enrolled, of which 120 patients taking voriconazole (43.6%) and 155 patients taking posaconazole (56.4%). The breakthrough of IFD occurred in 19 (15.8%) patients taking voriconazole and in 12 (7.7%) patients taking posaconazole (P = 0.035). There was no significant differences in IFD-free survival (P = 0.336) or OS (P = 0.069) between the patients taking voriconazole and posaconazole. In the subgroup of AML patients, the OS of patients taking posaconazole was better than those receiving voriconazole (P = 0.017).
Conclusions
Posaconazole and voriconazole were comparable for PAP in patients with paediatric acute leukemia regarding the OS and IFD-free survival, but posaconazole might achieve a lower IFD breakthrough rate.
WITHDRAWN: CCL19, not CCL21 induces CCR7-mediated stimulation of leukemia apoptosis by targeting endosomal signaling signaling
Authors: Sun Sylvia Y. 
Published: August 2023

Abstract

The chemokine system has emerged as a relevant target for anticancer therapy, with roles in most hallmarks of cancer. Here, the potential usefulness of CCR7 (Chemokine Receptor 7) specific agonists CCL19 (Chemokine ligand 19) and CCL21 (Chemokine ligand 21) as anti-leukemic drugs was investigated. We found that CCL19, not CCL21 was able to time-dependently decrease the proliferation and viability of Jurkat leukemic cells. This CCL19-induced cell death of leukemia is biased to CCR7 endosomal signaling but not CCR7 plasma signaling, even though the efficacy of Go/i signalling is the same. The cell death of Jurkat was accompanied by increased recycled CCR7 protein on the cell membrane; The apoptosis family members but also the MAPK system are uniquely involved, as evidenced by decreased transcription of proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B BRAF, Mitogen-Activated Protein Kinase 4 MAP4K4, Mitogen-Activated Protein Kinase 8 MAPK8 supported by RNA-Seq from Hek293_CCR7 and Jurkat leukemia. CCL19 down-regulated MAPK, suggesting CCL19 is an upstream regulator of MAPK family, which might be a mechanism of the cell death induced by CCL19. Altogether, the CCL19/CCR7 can kill leukemic cells through distinct pathways which are different from CCL21/CCR7 signalings implicating MAPK signaling events, and represent a new target of bioactive molecules with potential applications in anticancer therapy.
Synthesis, Characterization, and Biological Evaluation of Gabapentinoid Hybrids with Isoindole-1,3(2H)-dione Moiety as Potential Antioxidant, Antimicrobial, and Anticancer Agents
Authors: Jabbour Mirna , Al-Khayat Mohammad Ammar , Ktaifani Mahmoud Al 
Published: August 2023

AbstractPurpose:To synthesize new isoindole-1,3(2H)-dione derivatives by molecular hybridization of gabapentin, and pregabalin with phthalic anhydride derivatives, and to evaluate their biological activity as promising antioxidant, antimicrobial, and anticancer agents.Method:Molecular hybridization was successfully achieved by two procedures; synthesized compounds were characterized using analytical and spectral methods. The free radical scavenging properties of synthesized compounds were evaluated using the DPPH method. The antibacterial activity of synthesized compounds, and parent compounds was evaluated against two microbial gram-positive and gram-negative strains by the well diffusion method. Furthermore, we have studied the effect of compounds on proliferation, cell cycle, and cell death in two human cancer cell lines (Caco-2 and HCT-116).Results:Compounds1,3, and4exhibited a good free radical scavenging effect, compound3is the most effective with IC50value 2.525 µmol/mL. All Compounds showed antibacterial activity against E. coli and Staphylococcus Aureus related to concentration, while parent drugs did not exhibit any antibacterial effect. Compounds1and2showed a good zone of inhibition against Escherichia Coli at micromolar concentrations, and they are more effective than gentamycin sulfate. Treatment with the studied compounds suppresses proliferation, arrests progress throughout the cell cycle, and induces apoptosis in Caco-2 and HCT-116 cancer cells. Compound2is highly effective against Caco-2 cells and more effective than Thalidomide, with IC50value less than 1 µmol/L.Conclusion:Our results showed that molecular hybridization of gabapentin and Pregabalin in the isoindole-1,3(2H)-dione moiety results in promising anti-cancer and antimicrobial molecules. Results of this preliminary study show that halogenation of the isoindole-1,3(2H)-dione moiety improves antimicrobial and anticancer activity and that tetra-brominated derivatives are comparable to or more effective than related tetra-chlorinated derivatives.
SKRINING PESTISIDA, PARASIT PADA BUAH DAN SAYUR PADA IBU-IBU PKK GUJI BARU KEPA DURI, KEBUN JERUK, JAKARTA BARAT
Authors: Monica Puspa Sari  , Susilowati Rina Priastini 
Published: August 2023

Buah dan Sayur merupakan makanan yang kaya akan kandungan zat gizi seperti vitamin dan mineral, yang baik dikonsumsi tubuh untuk meningkatkan kesehatan. Namun yang harus menjadi perhatian dari konsumsi buah dan sayur tersebut adalah adanya kontaminan seperti residu pestisida serta adanya parasite pada buah dan sayur. Tujuan pengabdian masyarakat ini adalah memberikan penyuluhan dan demonstrasi bagaimana melakukan skrining terhadap sayur dan buah dari pestisida dan parasit kepada ibu-ibu PKK Guji Baru dengan pendekatan community based research. Sebanyak 49 ibu-ibu berpartisipasi dalam kegiatan pengabdian masyarakat ini. Sebanyak 16 (55,17%) peserta penyuluhan berusia antara 41-50 tahun, sedangkan berdasarkan pendidikan, rata-rata pendidikan tamat SMA sebanyak 20 orang (40,81%) dan berdasarkan pekerjaan sebanyak 42 (85,71%) orang peserta merupakan ibu rumah tangga. Berdasarkan tingkat pengetahuan dari 7 pertanyaan maka rata-rata tingkat pengetahuan ibu-ibu PKK adalah 79% sedangkan dari tingkat perilaku adalah sebesar 68,18%. Diharapkan adanya perubahan perilaku dari ibu-ibu PKK dalam mengolah sayur dan buah dengan benar sehingga menghasilkan makanan yang sehat bagi keluarga.
Flood hazard assessment in the Yesil River basin
Authors: Makhmudova Lyazzat , Moldakhmetov Marat , Mussina Ainur , Sambetbayev Dauren , Zharylkassyn Adilet 
Published: August 2023

Abstract

Due to population growth and densification, and expanding construction, disaster risk in the world and its specific parts of the world is steadily increasing. Earthquakes cause the most damage, followed by floods. Floods are characterized by the highest frequency of events. In this research, annual data on 25 hydrological gauging stations of the considered territory were used to study the characteristics of maximum discharges and maximum levels of rivers in the Yesil water management basin. Data on maximum water levels and discharges are generalized because they are most important in the study of floods and the organization of flood control. It is the maximum level that determines the area and depth of flooding of territories. This study assessed the provided values of maximum levels and maximum water discharges by several methods (method of moments, the graph-analytical method for the full distribution, truncated distribution). For assessing flood damage, a map of the distribution of the maximum floodplain inundation depth over the basin area was constructed, taking into account the flood hazard classification by floodplain inundation layer. Quantitative assessment of hydrological extremes characterizing the danger of flooding has been carried out for gauging stations of Yesil water management basin during this research.
Effect of magnetic fields on simultaneous nitrification and denitrification microbial systems
Authors: Song Xintong , Zhang Guanglu , Luan Jiajia , Liu Guicai , Wang Jiabin 
Published: August 2023

Abstract

Magnetic fields positively influence the nitrogen removal efficiency in activated sludge systems. However, the structural succession pattern of microorganisms by magnetic fields still remains further explored. In this paper, a magnetic simultaneous nitrification and denitrification (MSND) reactor was constructed, and the influence of optimized magnetic field intensity (0, 10, 20 and 30 mT) on the nitrogen removal efficiency was investigated at HRT 6 h, 28.0–30.0 °C, and pH 7.0–8.0. Molecular biology was used to investigate the succession process of the dominant microbial flora and the functional gene structure of MSND systems. The results showed that the denitrification effects of the MSND system were significantly enhanced, which contributed to the lower concentration of total nitrogen in the effluent of the magnetic reactor than that of the nonmagnetic group reactor. The magnetic fields induced the succession of microbial community structure and improved the stability of microbial communities, thereby the relative abundances of nitrifying and denitrifying bacteria, and the functional genes were improved. In particular, the abundance of functional genes related to gene proliferation and transmembrane transport was increased. Therefore, the efficient nitrogen removal was achieved, which gives inspiration in the enhanced wastewater treatment by magnetic fields.
Memorial Acadêmico, Experiência Monitorial e Aprendizagem Docente (2013-2016)
Authors: Ivo Felipe Cavalcanti , Da Cruz Barbosa Maria da Graça , Guimarães Caravlho Maria Elizete 
Published: August 2023

Resumo
Este trabalho é vinculado à História e à Memória, objetivando refletir acerca dos processos formativos da docência, constituídos e/ou (re)elaborados no decorrer do exercício monitorial nas disciplinas de História da Educação/CE/UFPB, entre 2013 e 2016. Os suportes teóricos perpassam a História do Tempo Presente, a Memória e as Representações Sociais. Tendo a escrita de si por método de pesquisa, analisa-se um memorial acadêmico, dialogando com autores, como David (2012), Nóvoa (2013), entre outros, em um processo de releitura sobre a Monitoria, espaço de constituição de identidade professoral, construída na práxis (ação-reflexão-ação). Os resultados indicam o exercício monitorial como elemento pedagógico constitutivo dos sujeitos em formação, concluindo-se que a experiência monitorial fortalece a tríade ensino-pesquisa-extensão e o memorial acadêmico é uma fonte histórica configuradora da docência e da escrita de si.
Palavras-chave: História. Memória. Formação Docente. Monitoria.
Desenvolvimento Profissional Docente de Professoras Experientes
Authors: Pereira Amarildo Gomes , Anunciato Rosa Maria Moraes 
Published: August 2023

Este trabalho, recorte de uma pesquisa de doutorado, norteada na abordagem qualitativa, focaliza o desenvolvimento profissional de professoras experientes inseridas num processo formativo viabilizado pela Rede de Aprendizagem e Desenvolvimento da Docência (ReAD), no 2ºS/2017 e 1º, 2º/2018[1]. Para a escrita deste artigo, analisamos as narrativas produzidas no decorrer da formação ofertada no período citado. Os resultados evidenciam que, as participantes se deparam com grandes desafios para desenvolver o trabalho docente e investirem em seu desenvolvimento profissional. Contudo, mesmo com as condições e trabalho desfavoráveis, elas encontram tempo e disposição para manter-se em processo de formação por meio de estudos individuais, participação em cursos e realização de segunda graduação, especialização e pós-graduação. Diante desses fatos, compreendemos que os programas de formação precisam levar em conta as necessidades formativas da docência em diferentes fases da carreira e as implicações que o trabalho tem na vida pessoal/familiar dos professores, contribuindo para à aquisição de novos conhecimentos, e no auxílio na superação dos entraves para investirem no próprio desenvolvimento profissional.

[1]Os participantes da ReAD no momento da realização da inscrição e cadastro foram informados da realização da pesquisa e convidados a assinar o termo de Termo de Consentimento Livre e Esclarecido.