bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sonographic features of adenomyosis correlated with clinical symptoms and intraoperative findings: a case–control study
Authors: Haj Hamoud Bashar , Kasoha Mariz , Sillem Martin , Solomayer Erich-Franz , Sima Romina-Marina , Ples Liana , Schwab Roxana , Olmes Gregor Leonhard 
Published: March 2023

Abstract
Purpose
Adenomyosis is a common disease of females during their reproductive age. As of today, histologic examination of the uterus after hysterectomy constitutes the gold standard for diagnosis. The aim of this study was to determine the validity of sonographic, hysteroscopic, and laparoscopic criteria for the diagnosis of the disease.

Methods
This study included data collected from 50 women in the reproductive age of 18–45 years, who underwent a laparoscopic hysterectomy in the gynecology department of the Saarland University Hospital in Homburg between 2017 and 2018. The patients with adenomyosis were compared with a healthy control group.

Results
We collected data of anamnesis, sonographic criteria, hysteroscopic criteria and laparoscopic criteria and compared it with the postoperative histological results. A total 25 patients were diagnosed with adenomyosis postoperatively. For each of these; at least three sonographic diagnostical criteria for adenomyosis were found compared with a maximum of two for the control group.

Conclusion
This study demonstrated an association between pre- and intraoperative signs of adenomyosis. In this way, it shows a high diagnostic accuracy of the sonographic examination as a pre-operative diagnostic method of the adenomyosis.
A parosmia severity index based on word-classification predicts olfactory abilities and impairment
Authors: Hörberg Thomas , Sekine Rumi , Overbeck Clara , Hummel Thomas , Olofsson Jonas K. 
Published: March 2023

AbstractParosmia is an olfactory disorder that involves distortions of specific odors that may co-occur with anosmia, loss of smell of other odors. Little is known about which odors frequently trigger parosmia, and measures of parosmia severity are lacking. Here, we present an approach to understand and diagnose parosmia that is based on semantic properties (e.g., valence) of words describing odor sources (“fish”, “coffee”, etc.). Using a data-driven method based on natural language data, we identified 38 odor descriptors. Descriptors were evenly dispersed across an olfactory-semantic space, which was based on key odor dimensions. Parosmia patients (n = 48) classified the corresponding odors in terms of whether they trigger parosmic or anosmic sensations. We investigated whether these classifications are related to semantic properties of the descriptors. Parosmic sensations were most often reported for words describing unpleasant odors of inedibles that are highly associated to olfaction (e.g., “excrement”). Based on PCA modeling, we derived the Parosmia Severity Index—a measure of parosmia severity that can be determined solely from our non-olfactory behavioral task. This index predicts olfactory-perceptual abilities, self-reported olfactory impairment, and depression. We thus provide a novel approach for investigating parosmia and establishing its severity that does not require odor exposure. Our work may enhance our understanding of how parosmia changes over time and how it is expressed differently across individuals.
Patterns, trends, and factors influencing hospitalizations for craniosynostosis in Western Australia. A population-based study
Authors: Junaid Mohammed , Slack-Smith Linda , Wong Kingsley , Hewitt Timothy , Bourke Jenny , Baynam Gareth , Calache Hanny , Leonard Helen 
Published: March 2023

AbstractUnderstanding hospital service use among children with a diagnosis of craniosynostosis (CS) is important to improve services and outcomes. This study aimed to describe population-level trends, patterns, and factors influencing hospitalizations for craniosynostosis in Western Australia. Data on live births (1990–2010; n = 554,624) including craniosynostosis, episodes of death, demographic, and perinatal factors were identified from the midwives, birth defects, hospitalizations, and death datasets. Information on craniosynostosis and non-craniosynostosis-related admissions, cumulative length of hospital stay (cLoS), intensive care unit, and emergency department–related admissions were extracted from the hospitalization dataset and linked to other data sources. These associations were examined using negative binomial regression presented as annual percent change and associations of hospitalizations by age groups, demographic, and perinatal factors were expressed as incidence rate ratio (IRR). We found an increasing trend in incident hospitalizations but a marginal decline in cLoS for craniosynostosis over the observed study period. Perinatal conditions, feeding difficulties, nervous system anomalies, respiratory, and other infections contributed to majority of infant non-CS-related admissions.Respiratory infections accounted for about twice the number of admissions for individuals with CS (IRRs 1.94–2.34) across all observed age groups. Higher incidence of non-CS hospitalizations was observed among females, with associated anomalies, to families with highest socioeconomic disadvantage and living in remote areas of the state. Conclusion: Marginal reduction in the cLoS for CS-related admissions observed over the 21-year period are potentially indicative of improved peri-operative care. However, higher incidence of respiratory infection-related admissions for syndromic synostosis is concerning and requires investigation.
Computing Bend-Minimum Orthogonal Drawings of Plane Series–Parallel Graphs in Linear Time
Authors: Didimo Walter , Kaufmann Michael , Liotta Giuseppe , Ortali Giacomo 
Published: March 2023

AbstractA planar orthogonal drawing of a planar 4-graph G (i.e., a planar graph with vertex-degree at most four) is a crossing-free drawing that maps each vertex of G to a distinct point of the plane and each edge of G to a polygonal chain consisting of horizontal and vertical segments. A longstanding open question in Graph Drawing, dating back over 30 years, is whether there exists a linear-time algorithm to compute an orthogonal drawing of a plane 4-graph with the minimum number of bends. The term “plane” indicates that the input graph comes together with a planar embedding, which must be preserved by the drawing (i.e., the drawing must have the same set of faces as the input graph). In this paper we positively answer the question above for the widely-studied class of series–parallel graphs. Our linear-time algorithm is based on a characterization of the planar series–parallel graphs that admit an orthogonal drawing without bends. This characterization is given in terms of the orthogonal spirality that each type of triconnected component of the graph can take; the orthogonal spirality of a component measures how much that component is “rolled-up” in an orthogonal drawing of the graph.
Bitonic st-Orderings for Upward Planar Graphs: Splits and Bends in the Variable Embedding Scenario
Authors: Angelini Patrizio , Bekos Michael A. , Förster Henry , Gronemann Martin 
Published: March 2023

AbstractBitonic st-orderings for st-planar graphs were introduced as a method to cope with several graph drawing problems. Notably, they have been used to obtain the best-known upper bound on the number of bends for upward planar polyline drawings with at most one bend per edge in polynomial area. For an st-planar graph that does not admit a bitonic st-ordering, one may split certain edges such that for the resulting graph such an ordering exists. Since each split is interpreted as a bend, one is usually interested in splitting as few edges as possible. While this optimization problem admits a linear-time algorithm in the fixed embedding setting, it remains open in the variable embedding setting. We close this gap in the literature by providing a linear-time algorithm that optimizes over all embeddings of the input st-planar graph. The best-known lower bound on the number of required splits of an st-planar graph with n vertices is $$n-3$$

n
-
3

. However, it is possible to compute a bitonic st-ordering without any split for the st-planar graph obtained by reversing the orientation of all edges. In terms of upward planar polyline drawings in polynomial area, the former translates into $$n-3$$

n
-
3

bends, while the latter into no bends. We show that this idea cannot always be exploited by describing an st-planar graph that needs at least $$n-5$$

n
-
5

splits in both orientations. We provide analogous bounds for graphs with small degree. Finally, we further investigate the relationship between splits in bitonic st-orderings and bends in upward planar polyline drawings with polynomial area, by providing bounds on the number of bends in such drawings.
Towards high-availability cyber-physical systems using a microservice architecture
Authors: Mena Manel , Criado Javier , Iribarne Luis , Corral Antonio , Chbeir Richard , Manolopoulos Yannis 
Published: March 2023

AbstractIn the past few years the use of IoT devices has grown exponentially. When it comes to working with them, we find a series of problems that are not easy to solve. On the one hand, the simple fact of communicating with those devices can be problematic since they can use different types of technologies regarding that communication. On the other hand, these types of devices usually aim to perform their function using the lowest possible energy, meaning they have certain constraints in terms of performance. Trying to work with these devices in high-availability environments becomes difficult because of those restraints. This paper introduces digital dice, a virtual representation of IoT devices and cyber-physical systems based on microservices that uses the standard established by the W3C, the Web of Things, as the underlying framework to declare its possible interactions. The article puts forward the different strategies that Digital Dice uses to mitigate the problems raised. Furthermore, we contrast the performance of Digital Dice with using the devices directly, demonstrating its advantages in a process that requires High Availability.
A novel vesivirus (family Caliciviridae) in European badgers (Meles meles) in Hungary, 2020/2021
Authors: Reuter Gábor , Pankovics Péter , Nagy Gábor , Szekeres Sándor , Boros Ákos 
Published: March 2023

AbstractIn this study, a novel vesivirus (family Caliciviridae) was detected and characterized in faecal and tissue (blood and spleen) specimens collected from three (23.1%) out of 13 European badgers (Meles meles) in Hungary that were tested using RT-PCR and sequencing methods. The complete genome of the vesivirus strain European badger/B40/2021/HUN (OQ161773) is 8,375 nucleotides in length. The ORF1, ORF2, and ORF3 proteins have 81.1%, 70.5%, and 64.2% amino acid sequence identity, respectively, to the corresponding proteins of Asian badger vesivirus, which was first reported in badgers in China in 2022. These results indicate that more than one lineage/species of vesiviruses circulates in mustelid badgers in geographically different regions.
Associations of premenstrual symptoms with daily rumination and perceived stress and the moderating effects of mindfulness facets on symptom cyclicity in premenstrual syndrome
Authors: Nayman Sibel , Konstantinow Desiree Tina , Schricker Isabelle Florence , Reinhard Iris , Kuehner Christine 
Published: March 2023

AbstractSubthreshold premenstrual symptoms can be impairing even if the diagnostic criteria for premenstrual dysphoric disorder (PMDD) are not reached. Previous research suggests shared psychological risk factors without a clear differentiation of premenstrual syndrome (PMS) from PMDD. This study focuses on a sample with a wide range of premenstrual symptoms not reaching PMDD-criteria and aims to investigate within-person associations of premenstrual symptoms with daily rumination and perceived stress during the late luteal phase as well as cycle-phase specific associations of habitual mindfulness including present-moment-awareness and acceptance with premenstrual symptoms and impairment. Fifty-six naturally cycling women with self-reported premenstrual symptoms completed an online diary on premenstrual symptoms, rumination and perceived stress over two consecutive menstrual cycles, and baseline questionnaires on habitual present-moment-awareness and acceptance. Multilevel analyses revealed cycle-related variations in premenstrual symptoms and impairment (allps < .001). Higher within-person levels of core and secondary premenstrual symptoms during the late luteal phase predicted increased daily rumination and perceived stress (allps < .001) and increased somatic symptoms predicted increased rumination (p ≤ .018). Higher habitual present-moment-awareness was linked to lower premenstrual symptom and impairment levels toward the late luteal phase whereas higher habitual acceptance was associated with lower premenstrual functional impairment (p ≤ .015). Premenstrual symptom increases during the late luteal phase in women with PMS seem to be linked to increased daily rumination and perceived stress. Trait present-moment-awareness and acceptance in turn seem to reflect protective factors against premenstrual distress and may represent useful targets for interventions.
Empirical evaluation of Easy Language recommendations: a systematic literature review from journal research in Catalan, English, and Spanish
Authors: González-Sordé Mariona , Matamala Anna 
Published: March 2023

AbstractEasy Language is a language variety that aims to make information more comprehensible and, ultimately, more accessible. Content in this variety is written and designed following a set of recommendations that have been published in different guidelines. However, it remains uncertain to what extent these recommendations are backed up by empirical research. The aim of this study is to review the existing literature that evaluates current recommendations in Easy Language guidelines, on the basis of the following research questions: (a) is there empirical research that evaluates current international Easy Language recommendations? and, (b) if so, what current international Easy Language recommendations are supported by empirical research and what results were obtained? To this end, we conducted a systematic literature review based on journal articles in three languages: Catalan, English, and Spanish. First, a systematic search was designed and performed in 10 databases of different fields of science. Then, we reviewed every article that resulted from the search and found that 6 publications out of the initial 617 met the inclusion criteria and could be considered relevant for the study. Based on the data extracted from the included publications, and after an overall review of our systematic search results, we safely state that there is indeed empirical research on some current Easy Language recommendations. Nevertheless, empirical research in the field (at least in the publication format and languages considered in our study) is not enough in terms of the number of publications, and the findings obtained are far from generalisable. Our literature review suggests future lines of research, and we hope that it fosters empirical studies in the field that help support the existing findings.
Clinicopathological and ultrasound characteristics of breast cancer in BRCA1 and BRCA2 mutation carriers
Authors: Ikejima Kengo , Tokioka Sayuri , Yagishita Kazuyo , Kajiura Yuka , Kanomata Naoki , Yamauchi Hideko , Kurihara Yasuyuki , Tsunoda Hiroko 
Published: March 2023

Abstract
Purpose
BRCA1 and BRCA2 tumors exhibit different characteristics. This study aimed to assess and compare the ultrasound findings and pathologic features of BRCA1 and BRCA2 breast cancers. To our knowledge, this is the first study to examine the mass formation, vascularity, and elasticity in breast cancers of BRCA-positive Japanese women.

Methods
We identified patients with breast cancer harboring BRCA1 or BRCA2 mutations. After excluding patients who underwent chemotherapy or surgery before the ultrasound, we evaluated 89 cancers in BRCA1-positive and 83 in BRCA2-positive patients. The ultrasound images were reviewed by three radiologists in consensus. Imaging features, including vascularity and elasticity, were assessed. Pathological data, including tumor subtypes, were reviewed.

Results
Significant differences in tumor morphology, peripheral features, posterior echoes, echogenic foci, and vascularity were observed between BRCA1 and BRCA2 tumors. BRCA1 breast cancers tended to be posteriorly accentuating and hypervascular. In contrast, BRCA2 tumors were less likely to form masses. In cases where a tumor formed a mass, it tended to show posterior attenuation, indistinct margins, and echogenic foci. In pathological comparisons, BRCA1 cancers tended to be triple-negative subtypes. In contrast, BRCA2 cancers tended to be luminal or luminal-human epidermal growth factor receptor 2 subtypes.

Conclusion
In the surveillance of BRCA mutation carriers, radiologists should be aware that the morphological differences between tumors are quite different between BRCA1 and BRCA2 patients.
Addressing the Know-Do Gap in Adolescent HIV: Framing and Measuring Implementation Determinants, Outcomes, and Strategies in the AHISA Network
Authors: Beima-Sofie Kristin , Njuguna Irene , Concepcion Tessa , DeLong Stephanie M. , Donenberg Geri , Zanoni Brian C. , Dow Dorothy , Braitstein Paula , Wagner Anjuli 
Published: March 2023

AbstractImplementation science (IS) uses systematic methods to close gaps between research and practice by identifying and addressing barriers to implementation of evidence-based interventions (EBIs). To reach UNAIDS HIV targets, IS can support programs to reach vulnerable populations and achieve sustainability. We studied the application of IS methods in 36 study protocols that were part of the Adolescent HIV Prevention and Treatment Implementation Science Alliance (AHISA). Protocols focused on youth, caregivers, or healthcare workers in high HIV-burden African countries and evaluated medication, clinical and behavioral/social EBIs. All studies measured clinical outcomes and implementation science outcomes; most focused on early implementation outcomes of acceptability (81%), reach (47%), and feasibility (44%). Only 53% used an implementation science framework/theory. Most studies (72%) evaluated implementation strategies. Some developed and tested strategies, while others adapted an EBI/strategy. Harmonizing IS approaches allows cross study learning and optimization of delivery of EBIs and could support attainment of HIV goals.
Could interventions on physical activity mitigate genomic liability for obesity? Applying the health disparity framework in genetically informed studies
Authors: Herle Moritz , Pickles Andrew , Pain Oliver , Viner Russell , Pingault Jean-Baptiste , De Stavola Bianca L. 
Published: March 2023

AbstractPolygenic scores (PGS) are now commonly available in longitudinal cohort studies, leading to their integration into epidemiological research. In this work, our aim is to explore how polygenic scores can be used as exposures in causal inference-based methods, specifically mediation analyses. We propose to estimate the extent to which the association of a polygenic score indexing genetic liability to an outcome could be mitigated by a potential intervention on a mediator. To do this this, we use the interventional disparity measure approach, which allows us to compare the adjusted total effect of an exposure on an outcome, with the association that would remain had we intervened on a potentially modifiable mediator. As an example, we analyse data from two UK cohorts, the Millennium Cohort Study (MCS, N = 2575) and the Avon Longitudinal Study of Parents and Children (ALSPAC, N = 3347). In both, the exposure is genetic liability for obesity (indicated by a PGS for BMI), the outcome is late childhood/early adolescent BMI, and the mediator and potential intervention target is physical activity, measured between exposure and outcome. Our results suggest that a potential intervention on child physical activity can mitigate some of the genetic liability for childhood obesity. We propose that including PGSs in a health disparity measure approach, and causal inference-based methods more broadly, is a valuable addition to the study of gene-environment interplay in complex health outcomes.
Co-Design of Augmented Reality Games for Learning with Teachers: A Methodological Approach
Authors: Tobar-Muñoz Hendrys , Baldiris Silvia , Fabregat Ramon 
Published: March 2023

AbstractAugmented Reality Game-Based Learning (ARGBL) is becoming increasingly relevant in Technology-Enhanced Learning. Games with AR characteristics, or even AR applications structured with rules and game elements, are proving to be effective and successful learning experiences. There is a need to include teachers in the design process. In this paper, two case studies are shown in order to validate a methodological approach for the co-design of ARGBL, in which 6 teachers participated. This is a co-design method that proposes a thorough, iterative process guided by design principles and mediated by dialogue among the stakeholders. Here, the process of co-design with teachers is analyzed and assessed using mixed-methods observations on the use of the produced ARGBL games with students on naturalistic environments. The validation process links the usefulness of the ensuing products with the use of the method and shows the benefits of using co-design methods to create ARGBL experiences.
Parent-Child Communication About Educational Aspirations: Experiences of Adolescents in Rural China
Authors: Chen Xiaodi , Allen Jennifer L. , Flouri Eirini , Cao Xinyi , Hesketh Therese 
Published: March 2023

AbstractThe importance of parents in the transmission of educational aspirations to children is well-established. However, little is known about the quality of parent-child communication about educational aspirations and how this communication relates to children’s educational aspirations in socioeconomically disadvantaged families in rural China. In this study, we sought to gain insight into parent-child communication around educational aspirations from the perspective of Chinese rural adolescents. Twenty-three grade-9 students were recruited from middle schools in Songzi, a poor rural county in central China. Participants comprised 12 boys and 11 girls aged 14 to 16 years (M = 14.65 years, SD = 0.59). Students completed one-to-one qualitative interviews about parent-child communication and their educational aspirations in June 2020. Thematic analysis revealed that adolescents’ educational aspirations were strongly influenced by their parents’ beliefs and aspirations for them, with fulfilling parental aspirations and achieving economic success being important influences on rural adolescents’ educational aspirations. However, parent-child communication quality was undermined when parents had an authoritarian communication style and when parents were absent due to rural-urban migration, in which case adolescents reported stress and perceived lack of support in achieving their goals. In addition, mothers were viewed as playing a more vital role in communication than fathers. The implications of the findings for school and community-based interventions promoting rural parents’ ability to communicate effectively with their children about academic concerns are discussed.