bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship of Megamonas species with nonalcoholic fatty liver disease in children and adolescents revealed by metagenomics of gut microbiota
Authors: Zhou Jianli , Zhang Qiao , Zhao Yuzhen , Zou Yu , Chen Moxian , Zhou Shaoming , Wang Zhaoxia 
Published: December 2022

AbstractNonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and adolescents. The gut microbiota plays an important role in the pathophysiology of NAFLD through the gut–liver axis. Therefore, we aimed to investigate the genus and species of gut microbiota and their functions in children and adolescents with NAFLD. From May 2017 to July 2018, a total of 58 children and adolescents, including 27 abnormal weight (AW) (obese) NAFLD patients, 16 AW non-NAFLD children, and 15 healthy children, were enrolled in this study at Shenzhen Children’s Hospital. All of them underwent magnetic resonance spectroscopy (MRS) to quantify the liver fat fraction. Stool samples were collected and analysed with metagenomics. According to body mass index (BMI) and MRS proton density fat fraction (MRS-PDFF), we divided the participants into BMI groups, including the AW group (n = 43) and the Lean group (n = 15); MRS groups, including the NAFLD group (n = 27) and the Control group (n = 31); and BMI-MRS 3 groups, including NAFLD_AW (AW children with NAFLD) (n = 27), Ctrl_AW (n = 16) (AW children without NAFLD) and Ctrl_Lean (n = 15). There was no difference in sex or age among those groups (p > 0.05). In the BMI groups, at the genus level, Dialister, Akkermansia, Odoribacter, and Alistipes exhibited a significant decrease in AW children compared with the Lean group. At the species level, Megamonas hypermegale was increased in the AW group, while Akkermansia muciniphila, Dialister invisus, Alistipes putredinis, Bacteroides massiliensis, Odoribacter splanchnicus, and Bacteroides thetaiotaomicron were decreased in AW children, compared to the Lean group. Compared with the Control group, the genus Megamonas, the species of Megamonas hypermegale and Megamonas rupellensis, increased in the NAFLD group. Furthermore, the genus Megamonas was enriched in the NAFLD_AW group, while Odoribacter, Alistipes, Dialister, and Akkermansia were depleted compared with the Ctrl_Lean or Ctrl_AW group at the genus level. Megamonas hypermegale and Megamonas rupellensis exhibited a significant increase in NAFLD_AW children compared with the Ctrl_Lean or Ctrl_AW group at the species level. Compared with healthy children, the pathways of P461-PWY contributed by the genus Megamonas were significantly increased in NAFLD_AW. We found that compared to healthy children, the genus Megamonas was enriched, while Megamonas hypermegale and Megamonas rupellensis were enriched at the species level in children and adolescents with NAFLD. This indicates that the NAFLD status and/or diet associated with NAFLD patients might lead to the enrichment of the genus Megamonas or Megamonas species.
Isolation and identification of Pithomyces sacchari as a leaf spot pathogen of Helianthus annuus from Pakistan
Authors: Shafique Shazia , Javed Alina , Shafique Sobiya , Hussain Abrar , Rafique Rubab , Mubarak Ayesha 
Published: December 2022

AbstractSunflower (Helianthus annuus L.) is an important annual crop known for its edible oil. Sunflower is susceptible to many fungal diseases including rusts, rotting, mildews, and leaf spots that result in low crop yield. Presently, infected leaves with leaf spot disease symptoms were collected from Jallo Park, Botanical Garden; University of the Punjab, Canal road, and Johar Town, Lahore for pathogen/s isolation and identification. The identification was executed morphologically as well as genetically by nucleotide sequencing of rDNA using Internal spacer region (ITS) and Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) primers. Morphological characters demonstrated a rapidly growing colony on MEA reaching 5.0–5.5 cm in diameter without zonation. The mycelial growth was rough and cottony white from the front and light pink from the reverse side. Conidia were brown, verruculose, and ellipsoidal with three to five transverse septations and one longitudinal septum ranging from 15 to 30 ± 2 µm in the broadest part. Conidiophores were long, branched, septate, 70–80 × 3–4 µm in size. Based on morphological characteristics, the pathogen was identified as Pithomyces sacchari. In genetic characterization BLAST analysis of the rDNA-ITS region of the pathogen exhibited maximum (100%) homology with other P. sacchari GenBank strains. Similarly, 99% homology was found with partial glyceraldehyde 3-phosphate dehydrogenase (GAPDH). To confirm the pathogenicity, Koch’s pathogenicity test was performed by inoculating artificial fungal suspension in pots and plate assays. The emergence of similar disease symptoms and re-isolation of the same pathogens verified Koch’s pathogenicity postulates. Conclusively this study confirms the identification of this novel pathogen of sunflowers and necessitates the quick development of management tools.
The novel anti-cancer feature of Brazzein through activating of hTLR5 by integration of biological evaluation: molecular docking and molecular dynamics simulation
Authors: Poursalim Maede , Shasaltaneh Marzieh Dehghan , Jafarian Vahab , Salehabadi Hafezeh 
Published: December 2022

AbstractMany of plant proteins exhibit the properties similar to the antitumor proteins although the anticancer activity of Brazzein on modulating the autophagy signaling pathway has not been determined so far. The present study aimed to develop a simplified system to enable the rational design of the activating extracellular domain of human Toll-like receptor 5 (hTLR5). To identify the anticancer effect of Brazzein, HADDOCK program and molecular dynamics (MD) simulation were applied to examine the binding of the wild type (WT) and p.A19K mutant of Brazzein to the TLR5. The expression of MAP1S and TNF-α genes was estimated based on real-time PCR. The results clearly confirmed that the WT of Brazzein activated hTLR5 in the MCF-7 cell line since the genes were more and significantly less expressed in the cells treated with the WT and p.A19K mutant than the control, respectively. The snapshots of MD simulation exhibit the consistent close interactions of hTLR5 with the two helices of Brazzein on its lateral side. The results of per residue-free energy decomposition analysis substantiate those of intermolecular contact analysis perfectly one. We propose that the WT of Brazzein can act as an antitumor drug candidate.
Machine learning prediction of academic collaboration networks
Authors: Resce Giuliano , Zinilli Antonio , Cerulli Giovanni 
Published: December 2022

AbstractWe investigate the different roles played by nodes’ network and non-network attributes in explaining the formation of European university collaborations from 2011 to 2016, in three European Research Council (ERC) domains: Social Sciences and Humanities (SSH), Physical and Engineering Sciences (PE), Life Sciences (LS), as well as multidisciplinary collaborations. On link formation in collaboration networks, existing research has not yet compared and simultaneously examined both network and non-network attributes. Using four machine learning predictive algorithms (LASSO, Neural Network, Gradient Boosting, and Random Forest) our results show that, over various model specifications: (i) best model link formation accuracy is larger than 80%, (ii) among the non-network attributes, public funding plays an important role in PE and LS, (iii) network attributes count more than non-network attributes for the formation, sensibly increasing accuracy, (iv) feature-importance scores show a different ordering in the four domains, thus signalling different modes of knowledge production and transmission taking place within these different scientific communities.
Design and analysis of consequent pole permanent magnet synchronous motor with low torque ripple
Authors: Guo Liyan , Li Qiang , Wang Huimin 
Published: December 2022

AbstractPermanent magnet (PM) motor with consequent pole (CP) rotor can improve the PM utilisation ratio. However, one group of PMs with the same polarity is replaced by iron core, which deteriorates the electromagnetic performances of the motor, including asymmetric air‐gap magnetic field and larger torque ripple. To solve this problem, this study analyses the relationship between the torque ripple and the stator‐rotor magnetomotive force (MMF) harmonics, determines the harmonic orders causing the torque ripple of the CP PM (CPPM) motor, and proposes an unequal‐turn four‐layer winding structure which can eliminate the determining harmonics in the stator MMF. Furthermore, the electromagnetic performances of the CPPM motors with the proposed winding structure and traditional CPPM motors are investigated by the finite‐element analysis. It is verified that the CPPM motor with the proposed structure has better motor performances.
Virtual composite impedance circulating current suppression strategy with adaptive adjustment capability
Authors: Zhang Jihong , Liu Yunfei , Wei Yili , Zhang Xin , Wu Zhenkui 
Published: December 2022

AbstractIn the process of accessing distributed power sources in microgrid, there will be serious coupling between active power and reactive power, which will lead to significant changes in the inverter outlet voltage and impedance and increase the circulating current phenomenon. The generation of circulating current will accelerate the aging of devices, reduce the inverter efficiency, and threaten the stable operation of the system. In this paper, the mechanism of circulating current generation is analysed, the basic characteristics of circulating current are studied, and an inverter parallel circulating current suppression strategy with adaptive virtual composite impedance and droop control dynamic adjustment algorithm is proposed. The virtual impedance setting can weaken the influence of line difference on system stability, make the system equivalent output impedance resistive, weaken the inductive device characteristics and reduce the circulating current amplitude; the adaptive droop algorithm implantation dynamically correlates the control power with the droop coefficient, enhance the power decoupling accuracy and weaken the circulating current influenced by power changes. The simulation platform and experimental setup established by the large‐scale simulation software PSCAD/EMTDC are used to study the basic scenarios of the inverter under two conditions of equal and unequal capacity, and the rationality of the proposed control strategy is tested.
SACNet: Shuffling atrous convolutional U‐Net for medical image segmentation
Authors: Wang Shaofan , Liu Yukun , Sun Yanfeng , Yin Baocai 
Published: December 2022

AbstractMedical images exhibit multi‐granularity and high obscurity along boundaries. As representative work, the U‐Net and its variants exhibit two shortcomings on medical image segmentation: (a) they expand the range of reception fields by applying addition or concatenate operators to features with different reception fields, which disrupts the distribution of the essential feature of objects; (b) they utilize the downsampling or atrous convolution to characterize multi‐granular features of objects, which can obtain a large range of reception fields but leads to blur boundaries of objects. A Shuffling Atrous Convolutional U‐Net (SACNet) for circumventing those issues is proposed. The significant component of SACNet is the Shuffling Atrous Convolution (SAC) module, which fuses different atrous convolutional layers together by using a shuffle concatenate operation, so that the features from the same channel (which correspond to the same attribute of objects) are merged together. Besides the SAC modules, SACNet utilizes an EP module during the fine and medium levels to enhance the boundaries of objects, and utilizes a Transformer module during the coarse level to capture an overall correlation of pixels. Experiments on three medical image segmentation tasks: abdominal organ, cardiac, and skin lesion segmentation demonstrate that, SACNet outperforms several state‐of‐the‐art methods and facilitates easy transplant to other semantic segmentation tasks.
Transient stability analysis of the standalone solar‐storage AC supply system based on grid‐forming and grid‐following converters during sudden load variation
Authors: Sun Huiqiang , Lin Xinchun , Chen Songbai , Ji Xiaotong , Liu Dan , Jiang Kezheng 
Published: December 2022

AbstractThe standalone solar‐storage AC supply system is an efficient form of utilizing renewable energy. The solar‐storage supply system normally includes two types of converters, grid‐forming (GFM) and grid‐following (GFL) converters. Nevertheless, the incompatibility of the dynamic performance between the GFM and GFL converters due to different control schemes may introduce the transient instability risk to the solar‐storage supply system. To address this issue, it is extremely necessary to perform transient stability analysis and stability‐enhanced control for such a system. In this paper, a sixth‐order model of the dc‐link timescale for the solar‐storage supply system is developed, whose accuracy and applicability are verified by comparing with the detailed electromagnetic model. Based on the derived model, the analysis demonstrates that the solar‐storage supply system faces the potential risk of transient instability under large disturbances of sudden load variation, due to the mismatch of the transient response speeds between virtual excitation control of the GFM converter and dc voltage control of the GFL converter. The transient stability boundary of the system is quantitatively investigated, by depicting the basin of attraction of the post‐disturbance equilibrium point. Furthermore, from the perspective of improving the coordination of the transient behaviours between the GFM converter and the GFL converter, the parameters related to virtual excitation control and dc voltage control are designed to enhance the transient stability of the system. Time‐domain simulations and real‐time simulations are conducted to validate the theoretical analysis.DC–AC power convertors, microgrids, power system control, power system transient stability, renewable energy power conversion
The dust-to-gas mass ratio of luminous galaxies as a function of their metallicity at cosmic noon
Authors: Popping Gergö , Shivaei Irene , Sanders Ryan L. , Jones Tucker , Pope Alexandra , Reddy Naveen A. , Shapley Alice E. , Coil Alison L. , Kriek Mariska 
Published: December 2022

Aims. We aim to quantify the relation between the dust-to-gas mass ratio (DTG) and gas-phase metallicity of z = 2.1 − 2.5 luminous galaxies and contrast this high-redshift relation against analogous constraints at z = 0.
Methods. We present a sample of ten star-forming main-sequence galaxies in the redshift range 2.1 < z < 2.5 with rest-optical emission-line information available from the MOSDEF survey and with ALMA 1.2 millimetre and CO J = 3 − 2 follow-up observations. The galaxies have stellar masses ranging from 1010.3 to 1010.6 M⊙ and cover a range in star-formation rate from 35 to 145 M⊙ yr−1. We calculated the gas-phase oxygen abundance of these galaxies from rest-optical nebular emission lines (8.4 < 12 + log(O/H) < 8.8, corresponding to 0.5−1.25 Z⊙). We estimated the dust and H2 masses of the galaxies (using a metallicity-dependent CO-to-H2 conversion factor) from the 1.2 mm and CO J = 3 − 2 observations, respectively, from which we estimated a DTG.
Results. We find that the galaxies in this sample follow the trends already observed between CO line luminosity and dust-continuum luminosity from z = 0 to z = 3, extending such trends to fainter galaxies at 2.1 < z < 2.5 than observed to date. We find no second-order metallicity dependence in the CO – dust-continuum luminosity relation for the galaxies presented in this work. The DTGs of main-sequence galaxies at 2.1 < z < 2.5 are consistent with an increase in the DTG with gas-phase metallicity. The metallicity dependence of the DTG is driven by the metallicity dependence of the CO-to-H2 conversion factor. Galaxies at z = 2.1 − 2.5 are furthermore consistent with the DTG-metallicity relation found at z = 0 (i.e. with no significant evolution), providing relevant constraints for galaxy formation models. These results furthermore imply that the metallicity of galaxies should be taken into account when estimating cold-gas masses from dust-continuum emission, which is especially relevant when studying metal-poor low-mass or high-redshift galaxies.
Progress towards a 3D Monte Carlo radiative transfer code for outflow wind modelling
Authors: Fišák J. , Kubát J. , Kubátová B. , Kromer M. , Krtička J. 
Published: December 2022

Context. Radiative transfer modelling of expanding stellar envelopes is an important task in their analysis. To account for inhomogeneities and deviations from spherical symmetry, it is necessary to develop a 3 D approach to radiative transfer modelling.Aims. We present a 3 D Monte Carlo code for radiative transfer modelling, which is aimed to calculate the plasma ionisation and excitation state with the statistical equilibrium equations, moreover, to implement photon-matter coupling. As a first step, we present our Monte Carlo radiation transfer routines developed and tested from scratch.Methods. The background model atmosphere (the temperature, density, and velocity structure) can use an arbitrary grid referred to as the modGrid. The radiative transfer was solved using the Monte Carlo method in a Cartesian grid, referred to as the propGrid. This Cartesian grid was created based on the structure of the modGrid; correspondence between these two grids was set at the beginning of the calculations and then kept fixed. The propGrid can be either regular or adaptive; two modes of adaptive grids were tested. The accuracy and calculation speed for different propGrids was analysed. Photon interaction with matter was handled using the Lucy’s macroatom approach. Test calculations using our code were compared with the results obtained by a different Monte Carlo radiative transfer code.Results. Our method and the related code for the 3 D radiative transfer using the Monte Carlo and macroatom methods offer an accurate and reliable solution for the radiative transfer problem, and are especially promising for the inclusion and treatment of 3 D inhomogeneities.
Photochemical escape of atomic C and N on Mars during the X8.2 solar flare on 10 September 2017
Authors: Gu H. , Wu X.-S. , Cui J. 
Published: December 2022

Context. Characterizing the response of the upper Martian atmosphere to solar flares could provide important clues as to the climate evolution of the red planet in the early Solar System, when the extreme ultraviolet and soft X-ray radiation was substantially higher than the present-day level and when these events occurred more frequently. A critical process herein is the Martian atmospheric escape in the form of atomic C and N, as mainly driven by CO2/CO and N2 dissociation.
Aims. This study is devoted to evaluating how these escape rates varied on the dayside of Mars during the X8.2 solar flare on 10 September 2017.
Methods. The background Martian atmospheric structures, before, during, and after the flare, are constructed from the Neutral Gas and Ion Mass Spectrometer measurements made on board the Mars Atmosphere and Volatile Evolution spacecraft, from which the hot C and N production rate profiles via different photon and photoelectron impact channels and on different flare stages are obtained. They are combined with the respective escape probability profiles computed using a test particle Monte Carlo approach to derive the atomic C and N escape rates on the dayside of Mars.
Results. Our calculations indicate that the pre-flare C and N escape rates are (1.3−1.4) × 1024 s−1 over the dayside of Mars. During the event, we find a modest decrease in the C escape rate of 8% about 1 h after the flare peak, followed by a recovery to the pre-flare level several hours later. However, an opposite trend is found for the N escape rate during the same period, which shows an increase of 20% followed by a recovery to the pre-flare level.
Conclusions. The distinction between C and N in terms of the variation in the escape rate during the solar flare reflects the competition between two flare-induced effects: enhanced hot atom production via dissociation and enhanced collisional hindrance due to atmospheric expansion.
Solar flare hard X-rays from the anchor points of an eruptive filament
Authors: Zoë Stiefel Muriel , Battaglia Andrea Francesco , Barczynski Krzysztof , Collier Hannah , Volpara Anna , Massa Paolo , Schwanitz Conrad , Tynelius Sofia , Harra Louise , Krucker Säm 
Published: December 2022

Context.We present an analysis of a GOES M1.8 flare with excellent observational coverage in UV, extreme-UV (EUV), and X-ray, including observations from the Interface Region Imaging Spectrograph (IRIS), from the Solar Dynamics Observatory (SDO) with the Atmospheric Imaging Assembly (AIA), from the Hinode/EUV Imaging Spectrometer (EIS), from the Hinode/X-ray Telescope (XRT), and from Solar Orbiter with the Spectrometer/Telescope for Imaging X-rays (STIX). Hard X-ray emission is often observed at the footpoints of flare loops and is occasionally observed in the corona. In this flare, four nonthermal hard X-ray sources are seen.Aims.Our aim is to understand why we can observe four individual nonthermal sources in this flare and how we can characterize the physical properties of these four sources.Methods.We used the multiwavelength approach to analyze the flare and characterize the four sources. To do this, we combined imaging at different wavelengths and spectroscopic fitting in the EUV and X-ray range.Results.The flare is eruptive with an associated coronal mass ejection, and it shows the classical flare picture of a heated flare loop seen in EUV and X-rays, and two nonthermal hard X-ray footpoints at the loop ends. In addition to the main flare sources, we observed two outer sources in the UV, EUV, and nonthermal X-ray range located away from the main flare loop to the east and west. The two outer sources are clearly correlated in time, and they are only seen during the first two minutes of the impulsive phase, which lasts a total of about four minutes.Conclusions.Based on the analysis, we determine that the outer sources are the anchor points of an erupting filament. The hard X-ray emission is interpreted as flare-accelerated electrons that are injected upward into the filament and then precipitate along the filament toward the chromosphere, producing Bremsstrahlung. While sources like this have been speculated to exist, this is the first report of their detection.