bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chinese Empirical Dietary Inflammatory Index Is Associated with High Risk of Systematic Inflammation and Aging in Rural China
Authors: Lyu Lu , Yu Jie , Liu Yiwen , He Shuli , Qi Mengya , Yang Na , He Liyun , Wang Jialu , Ping Fan , Xu Lingling , Zhang Huabing , Li Wei , Li Yuxiu 
Published: May 2023

Abstract
Background：China is rapidly transforming into an aging society and houses the largest elderly population in the world. Diet patterns increase inflammation and oxidative stress, which may provide effective intervention strategies for mitigating the health burden in aging societies. This study sought to develop a Chinese empirical dietary inflammatory index(CEDII) that assesses Chinese diet quality based on its inflammatory potential and examine whether the index was associated with an accelerated aging process.
Methods:A cross-sectional study conducted in the community of Beijing recruited 388 participants. Dietary intake was collected based on 24-h dietary recalls. The Chinese Diet Balance Index(DBI) and its derivatives, as well as the empirical dietary inflammatory pattern(EDIP) based on the western diet, were calculated to assess dietary quality in different aspects. Chinese empirical dietary inflammatory index(CEDII) was derived using reduced-rank regression(RRR) according to Chinese diet patterns. The population was categorized into tertiles of the CEDII. Leukocyte telomere length(LTL) and mitochondrial DNA copy number(mtDNAcn) were determined by polymerase chain reaction assay. Tumor necrosis factor α(TNFα) and interleukin-6(IL-6), 8-oxo-2'-deoxyguanosine (8-oxo-dG), superoxide dismutase (SOD) activities, and glutathione reductase (GR) were measured.
ResultsA total of 388 subjects were enrolled. High CEDII group was characterized by high intake of carbohydrates. This pattern predicted higher levels of TNFα, IL-6, shorter LTL and lower mtDNAcn. Neither DBI nor EDIP was correlated with biomarkers of inflammation or aging. High CEDII scores were associated with short LTL and decreased mtDNAcn using multivariate linear regression with adjustment for confounding variables. The stratified analysis demonstrated that the high CEDII group had an increased risk of short LTL in subjects with abnormal metabolic status.
Conclusions: This study developed a Chinese empirical dietary inflammatory index(CEDII). High CEDII scores were associated with an increased risk of aging. Compared with indexes related to DBI and EDIP, CEDII was much more effective in assessing inflammation and aging potential of diet patterns for Chinese residents.
Complex method of diagnosing soft potato rot caused by P. carotovorum
Authors: Zhumayeva Araigul , Bogdanov Ilgizar 
Published: May 2023

Abstract
Pectobacterium carotovorum bacteria are facultative pathogens which cause diseases of various plant species, in many cases causing great economic damage. The research aim is to develop a complex method for diagnosing soft potato rot caused by Pectobacterium carotovorum. Soil samples, water from open reservoirs, sewage, plant residues, and potatoes with signs of soft rot were used in the research. From 123 samples of phytosanitary control and environmental objects, 14 strains were classified as Pectobacterium carotovorum spp.carotovorum. The obtained results of research on the biological properties of bacteria isolated by us are basically consistent with the data of reference strains. Based on the developed bacteriological scheme for the identification of Pectobacterium carotovorum spp.carotovorum bacteria, including 27 indicators, 14 strains were identified, typed as Pectobacterium carotovorum spp.carotovorum. It was established that within 168 hours, using the developed scheme for isolation and bacteriological identification of bacteria Pectobacterium carotovorum spp.carotovorum, it’s possible to type the above-mentioned bacteria based on 27 tests. However, the length and material intensity of research do not allow us to say that this method is effective for routine research. Phagoidentification of isolated strains of P.carotovorum spp.carotovorum was proved by the results of checking biochemical properties of bacteria. Out of 12 samples, 5 were identified as P.carotovorum spp.carotovorum. The conducted research proves the possibility of applying the identification scheme of bacterium P.carotovorum spp.carotovorum using introduced bacteriophage biopreparation consisting of RCC bacteriophages-1 UlGAU and РСС-37 UlGAU allowing to reduce the time spent on research several times (from 168 hours to 88 hours).
Protease-Activated Receptor 1 (PAR1) Expression Contributes to HPV-Associated Oropharyngeal Cancer Prognosis
Authors: Fujita Yoshinori , Fukuda Yujiro , Sanuki Fumiaki , Irei Isao , Monobe Yasumasa , Uno Masako , Akisada Takeshi , Shimoya Koichiro , Hara Hirotaka , Moriya Takuya 
Published: May 2023

Abstract
Background: Human papillomavirus (HPV)-associated oropharyngeal cancer occasionally has a poor prognosis, making prognostic risk stratification crucial. Protease-activated receptor-1 (PAR1) is involved in carcinogenesis and is regulated by alpha-arrestin domain-containing protein 3 (ARRDC3). It is also involved in the tumor microenvironment. We sought to evaluate the predictive ability of PAR1, ARRDC3, and tumor-infiltrating lymphocyte (TIL) scores in patients with oropharyngeal, hypopharyngeal, and uterine cervical cancers, serving as comparators for HPV-associated oropharyngeal cancer.
Methods: Immunohistochemical analysis of p16, ARRDC3, and PAR1 expression was performed for 79 oropharyngeal, 44 hypopharyngeal, and 42 uterine cervical cancer samples. The TIL scores were assessed and classified into the following groups based on invasion: Low: 0 %–10 %, Medium: 20 %–40 %, and high: >50 %. For prognostic analysis, the three groups were evaluated by dividing them into low, medium, and high categories, or alternatively into two groups using the median value as the cutoff.
Results: p16 was expressed in 44 (56 %) oropharyngeal, 8 (18 %) hypopharyngeal, and all uterine cervical cancer samples. ARRDC3 was detected in 39 (49 %) oropharyngeal, 25 (57 %) hypopharyngeal, and 23 (55 %) uterine cervical cancer samples. PAR1 was expressed in 45 (57 %) oropharyngeal, 22 (50 %) hypopharyngeal, and 22 (50 %) uterine cervical cancer samples. Patients diagnosed with p16-positive oropharyngeal cancer had a substantially improved prognosis compared to those diagnosed as p16-negative cases. Compared to the p16-positive cases, the PAR1-negative cases had a considerably improved prognosis compared to the positive cases (disease-specific survival [DSS] and -negative cases (disease-free survival [DFS]). Multivariate analysis revealed that ARRDC3-positive cases had an appreciably better DSS prognosis than patients with p16-negative oropharyngeal cancers.PAR1-positive cases among patients with p16-positive oropharyngeal cancer had a poor prognosis. With respect to DFS, patients with PAR1-positive and p16-negative oropharyngeal cancer had a 35-fold higher recurrence rate than those with PAR1-negative and p16-negative oropharyngeal cancer.
Conclusion: Our results suggest that PAR1 expression affects the prognosis and recurrence rate of HPV-associated oropharyngeal cancer.
Complete chloroplast genome sequences of the ornamental plant Prunus Cistena and comparative and phylogenetic analyses with its closely related species
Authors: Feng Lijuan , Zhao Guopeng , An Mengmeng , Wang Chuanzeng , Yin Yanlei 
Published: May 2023

Abstract
Background Prunus Cistena is an excellent color leaf configuration tree for urban landscaping in the world, which has purplish red leaves, light pink flowers, plant shape and high ornamental value. Genomic resources for P. Cistena are scarce, and a clear phylogenetic and evolutionary history for this species has yet to be elucidated. Here, we sequenced and analyzed the complete chloroplast (cp) genome of P. Cistena and compared it with related species of Prunus genus based on chloroplast genome.Results The complete chloroplast genome of P. Cistena was 157,935 bp in length, which had a typical tetrad structure. The overall GC content was 36.72%, while IR regions displayed a higher GC content than LSC and SSC regions. It encoded 130 genes, including 85 protein-coding genes, 37 tRNA genes, and 8 rRNA genes. The ycf3 and clpP genes had two introns; the longest intron was trnK-UUU gene in the LSC region. There were 253 SSRs, and the mononucleotide SSRs were the most abundant. The chloroplast sequences and gene arrangements of P. Cistena were conserved, which overall structure and gene order were similar to other Prunus species. The atpE, ccsA, petA, rps8 and matK gene had significant positive selection in Prunus species. P. Cistena had a close evolutionary relationship with the P. jamasakura. The coding region and IR region were more conserved than noncoding region, and the cpDNA sequences highly conserved throughout the genus Prunus.Conclusions The current genomic datasets provide valuable information for further species identification, evolution, and phylogenetic research of genus Prunus.
A Psicologia Educacional no âmbito da pós-graduação em Educação
Authors: Ribeiro Cynara Teixeira , Dos Reis Gusmão Andrade Erika 
Published: May 2023

O debate acerca da inserção social e internacionalização justifica-se pelo fato de que estes são indicadores adotados pela CAPES para a avaliação dos programas de pós-graduação. Nosso objetivo é analisar em que medida os trabalhos apresentados pelo GT 20 – Psicologia da Educação da ANPEd (2011 a 2020) permitem evidenciar o compromisso com a inserção social e a internacionalização na produção de conhecimento nesta área. Foram consideradas quatro dimensões de análise apontadas pela literatura para cada indicador. Consideramos sessenta trabalhos, dos quais só 6,66% explicitam o atendimento a demandas sociais circunstanciadas. A maioria dialoga com a produção internacional, havendo, no entanto, pouca parceria entre autores que visam à construção de redes de conhecimento, além da prevalência de autores da Região Sudeste. A alta incidência de trabalhos publicados posteriormente, como artigos em periódicos, contraria a afirmação de que as publicações da área se concentram em livros.
Total Synthesis of Xestodecalactone C via Sharpless Epoxidation and
Friedal-Crafts Acylation
Authors: Sudhakar Chithaluri , Prasad Kottolla Sai , Ramesh Batharaju 
Published: May 2023

Abstract:
Marine-derived macrolides that occur naturally exhibit a range of biological properties, including
antibacterial and antifungal activity.

:
Sharpless epoxidation and intramolecular acylation via the Friedel-Crafts method for the macrolide
ring formation was used as the main steps in the regioselective construction of naturally existing xestodecalactone
C, which was started from chiral propylene oxide.

:
The isolated yellow coloured final product had a 91% yield, and FT-IR, Mass, 1H-NMR, and 13C
NMR were used to characterise each product. As a result, chiral propylene oxide was used as the starting
material for the regioselective total synthesis of the naturally occurring xestrodecalactone C, with
the main stages being intramolecular Friedel-Crafts acylation for macrolide ring formation and Sharpless
epoxidation. The synthesis of numerous xestrodecalactone C analogues relevant for bioevaluation
can be done quickly and easily using this synthetic approach.
Evaluating the Potential of Green Light Exposure on Nociception-A Mini
Review
Authors: Qaiser Hammad , Uzair Mohammad , Arshad Muhammad , Zafar Anessa , Bashir Shahid 
Published: May 2023

Abstract:
The capacity of animals to react to unpleasant stimuli that might endanger their integrity is
known as nociception. Pharmacological treatments do not show satisfactory results in response to nociception.
In the recent era, light therapy emerged as a potential non-pharmacological approach for
treating various diseases, including seasonal affective disorders, migraine, pain, and others. Evaluating
the potential of green light exposure on nociception involves studying its effects on different types of
pain and pain-related conditions and determining the optimal exposure methods. This review provides
the beneficial effects of green light on the reduction in the frequency of pain. The green light exposure
on nociception changes the activity of pain-related genes and proteins in cells. This review could provide
insights into the underlying mechanisms by which green light modulates pain. Overall, evaluating
the potential of green light exposure on nociception requires a multidisciplinary approach and should
consider the safety, efficacy, optimal dose, and duration of green light exposure and the type of pain.
However, few studies have been reported so far; therefore, light therapy for treating migraines require
more studies on animal models to provide precise results of light effects on nociception.
Risk Factors Associated With Primary Care–Reported Domestic Violence for Women Involved in Family Law Care Proceedings: Data Linkage Observational Study
Authors: Johnson Rhodri D , Griffiths Lucy J , Cowley Laura E , Broadhurst Karen , Bailey Rowena 
Published: May 2023

Background
Domestic violence and abuse (DVA) has a detrimental impact on the health and well-being of children and families but is commonly underreported, with an estimated prevalence of 5.5% in England and Wales in 2020. DVA is more common in groups considered vulnerable, including those involved in public law family court proceedings; however, there is a lack of evidence regarding risk factors for DVA among those involved in the family justice system.

Objective
This study examines risk factors for DVA within a cohort of mothers involved in public law family court proceedings in Wales and a matched general population comparison group.

Methods
We linked family justice data from the Children and Family Court Advisory and Support Service (Cafcass Cymru [Wales]) to demographic and electronic health records within the Secure Anonymised Information Linkage (SAIL) Databank. We constructed 2 study cohorts: mothers involved in public law family court proceedings (2011-2019) and a general population group of mothers not involved in public law family court proceedings, matched on key demographics (age and deprivation). We used published clinical codes to identify mothers with exposure to DVA documented in their primary care records and who therefore reported DVA to their general practitioner. Multiple logistic regression analyses were used to examine risk factors for primary care–recorded DVA.

Results
Mothers involved in public law family court proceedings were 8 times more likely to have had exposure to DVA documented in their primary care records than the general population group (adjusted odds ratio [AOR] 8.0, 95% CI 6.6-9.7). Within the cohort of mothers involved in public law family court proceedings, risk factors for DVA with the greatest effect sizes included living in sparsely populated areas (AOR 3.9, 95% CI 2.8-5.5), assault-related emergency department attendances (AOR 2.2, 95% CI 1.5-3.1), and mental health conditions (AOR 1.7, 95% CI 1.3-2.2). An 8-fold increased risk of DVA emphasizes increased vulnerabilities for individuals involved in public law family court proceedings.

Conclusions
Previously reported DVA risk factors do not necessarily apply to this group of women. The additional risk factors identified in this study could be considered for inclusion in national guidelines. The evidence that living in sparsely populated areas and assault-related emergency department attendances are associated with increased risk of DVA could be used to inform policy and practice interventions targeting prevention as well as tailored support services for those with exposure to DVA. However, further work should also explore other sources of DVA, such as that recorded in secondary health care, family, and criminal justice records, to understand the true scale of the problem.
Gender-Specific Association Between Perceived Stigma Toward Tuberculosis and Acceptance of Preventive Treatment Among College Students With Latent Tuberculosis Infection: Cross-Sectional Analysis
Authors: Yuan Yemin , Jin Jin , Bi Xiuli , Geng Hong , Li Shixue , Zhou Chengchao 
Published: May 2023

Background
With the increasing enrollment scale of colleges, the number of students on campus has risen sharply in China. The number of students with tuberculosis (TB) and rifampicin-resistant TB in colleges has increased significantly. Preventive treatment of latent tuberculosis infection (LTBI) is an important means for TB prevention and control in colleges. At present, the acceptance of LTBI treatment among college students remains unclear. In addition, evidence shows stigma may be one of the key factors affecting acceptance of LTBI treatment. To date, there is little direct evidence on the gender-specific association between perceived stigma toward TB and acceptance of LTBI treatment among college students.

Objective
This study aimed to describe the acceptance of LTBI treatment among college students in an eastern province of China to explore the association between perceived stigma toward TB and acceptance of LTBI treatment and to examine the moderating effect of gender on the association.

Methods
Data were derived from the project on the evaluation of LTBI treatment and its effectiveness among college students in Shandong, China. In total, 1547 college students were included in the analysis. We considered covariates at the individual and family levels. Multilevel mixed-effects logistic regression was used to examine the moderating role of gender and also explore the association between perceived stigma toward TB and acceptance of LTBI treatment.

Results
The acceptance rate of LTBI treatment among the diagnosed college students was 46.7% (n=723). The proportion of female students (n=361, 51.5%) accepting LTBI treatment was higher than that of male students (n=362, 42.8%; P=.001). There was an interaction between perceived stigma toward TB and gender (OR 0.93, 95% CI 0.87-1.00; P=.06). Among college students with LTBI, perceived stigma toward TB was positively associated with acceptance of preventive treatment (OR 1.03, 95% CI 1.00-1.08, P=.05). Perceived stigma toward TB was positively associated with accepting LTBI treatment only among male students (OR 1.07, 95% CI 1.02-1.12; P=.005).

Conclusions
The acceptance rate of preventive treatment among college students with LTBI was low. Contrary to our expectations, perceived stigma toward TB was positively associated with acceptance of preventive treatment. Gender moderated this association; high perceived stigma toward TB was associated with acceptance of preventive treatment only in male gender. Gender-specific strategies are effective in improving the acceptability of LTBI treatment in colleges.
Evaluating the Effectiveness of Rural Digital Social Prescribing in Korea: Protocol for a Cohort Study
Authors: Lee Hocheol , Koh Sang Baek , Jo Heui Sug , Lee Tae Ho , Nam Hae Kweun , Zhao Bo , Lim Subeen , Lim Joo Aeh , Lee Ho Hee , Hwang Yu Seong , Kim Dong Hyun 
Published: May 2023

Background
The UK National Health Service (NHS) has introduced a digital social prescribing (DSP) system to improve the mental health of the aging population. In Korea, an ongoing pilot social prescribing project has been implemented for older individuals in rural areas since 2019.

Objective
This research aims to develop a DSP program and to evaluate the effectiveness of the digital platform in rural areas of Korea.

Methods
This study was designed as a prospective cohort method for the development and effectiveness evaluation of rural DSP in Korea. The study divided participants into four groups. Group 1 will continuously implement the existing social prescribing program, group 2 implemented the existing social prescribing program but was switched to DSP in 2023, group 3 newly started the DSP, and the remaining group is the control. The research area of this study is Gangwon Province in Korea. The study is being conducted in Wonju, Chuncheon, and Gangneung. This study will use indicators to measure depression, anxiety, loneliness, cognitive function, and digital literacy. In the future, the interventions will implement the digital platform and the Music Story Telling program. This study will evaluate the effectiveness of DSP using difference-in-differences regression and cost-benefit analysis.

Results
This study was approved for funding from the National Research Foundation of Korea funded by the Ministry of Education in October 2022. The results of the data analysis are expected to be available in September 2023.

Conclusions
The platform will be spread to rural areas in Korea and will serve as the foundation for effectively managing the feelings of solitude and depression among older individuals. This study will provide vital evidence for disseminating DSP in Asian countries such as Japan, China, Singapore, and Taiwan as well as for studying DSP in Korea.

International Registered Report Identifier (IRRID)
PRR1-10.2196/46371
DAMPAK IMPLEMENTASI APLIKASI PENDAFTARAN DARING PELAYANAN RAWAT JALAN RUMAH SAKIT
Authors: Yohana Denyka Kurniawati  , Hanevi Djasri  , Adi Utarini  
Published: May 2023

Background: Outpatients at the polyclinic of Dr. Oen Solo Baru Hospital complained to the hospital regarding the waiting time from registration to the specialist clinic. Meanwhile, the policy of a tiered referral system also causes an accumulation of patients. Hospitals
have been trying to increase the speed of outpatient services by implementing an online registration application since July 2010. Still, there has never been an evaluation of the implementation of the application.
Objective: To assess the impact of using the online registration application on waiting time for outpatients and to identify the constraints in implementing the online registration application and the possibility of developing this application in the future.
Methods: A mixed-method with explanatory sequential design. A quantitative approach to measure the difference in waiting time of outpatients before and after implementing the online registration application and the patient’s experience of using the application. Qualitative method to explore application implementation constraints and management’s strategy for application development.
Results: There is a difference in outpatient waiting time before and after implementing the online registration application. Before the online registration application, the average waiting time is 1.97 + 0.92 hours. After implementation, 1.49 +1.06 hours for patients who register manually (there is an acceleration of 24.4%) and 1.69 +0.93 hours for patients who use the application (there is an acceleration of 18.8%). Some of the obstacles found were application utilization which was still stagnant, patient problems related to gadgets, and a penalty and blocklist system. The strategy that will be taken by hospital management is to increase the use and development of applications, namely increasing promotions, increasing service ac
cess, developing towards e-payments, and commercial benefits.
Conclusion: The online registration application can significantly reduce the waiting time for outpatients and meet user expectations. However, the number of users is still stagnant, and there are still obstacles that prevent patients from switching to using the application. Efforts need to increase the number of users and develop online registration applications.