bluuebunny/crossref_metadata_2025_split huggingface dataset:
HOST AND PLANT TAXONOMY AS INFLUENTIAL FACTORS IN CONTROLING IN VITRO SPECIFIC CELL-MEDIATED RESPONSE IN HERBIVORES
Authors: AUREL Vasiu , SANDRU Carmen , PALL Emoke , UNGUREANU Emilia , MARİAN Florina , POPESCU Silvana , OPRESCU Alexandra , ILASCA Ciprian 
Published: September 2023

Objective: This study monitored several alcoholic vegetal extracts from the adjuvant and immune cell stimulating
perspective in farmed herbivores, differing by their digestive physiology.
Material and Methods: Blood from randomly selected farmed ruminants (Romanian Spotted dairy cows, n=28
and Angora goats, n=19) and Romanian draft horses (n=27) was used to measure the in vitro effects on specific
cell-mediated reactivity of alcoholic extracts of Calendula officinalis, Echinacea angustifolia and E. purpurea, by the
in vitro whole blood blast transformation test, in 96 well plates, after 60 to 72h of incubation. Cell growth was
quantiﬁed by an orto-toluidine technique. Student’s t- test was used to evaluate the statistical significance of the
differences.
Results&amp;Discussion: The in vitro growth indices were lowest in goats (C. officinalis - 58.52±10.02%,
E.angustifolia - 50.06±11.67%, E.purpurea -50.79±10.98%) and higher in bovine (C. officinalis – 69.9±2.65%,
E.angustifolia - 74.9±10.1%, p&lt;0.05), and increased towards E. angustifolia versus C. officinalis.
In vitro responses to C. officinalis, E. angustifolia and E.purpurea were the most pronounced in horses and similar
for all of these extracts.
Conclusion: All the extracts showed inhibiting effects in bovine and goats, but not in horses, supporting host-
based differences. The biological activity of the tested extracts was plant species dependent.
The El Gordo Galaxy Cluster Challenges ΛCDM for Any Plausible Collision Velocity
Authors: Asencio Elena , Banik Indranil , Kroupa Pavel 
Published: September 2023

Abstract
El Gordo (ACT-CL J0102-4915) is an extraordinarily large and bright galaxy cluster collision. In a previous study, we found that El Gordo is in 6.2σ tension with the Λ cold dark matter (ΛCDM) standard model when assuming the nominal mass and infall velocity values from the hydrodynamical simulations of Zhang et al. (M
200 = 3.2 × 1015
M
⊙ and V
infall = 2500 km s−1, respectively). The recent weak-lensing study of Kim et al. showed that the mass of El Gordo is actually

2.13

−
0.23

+
0.25

×

10

15

M

⊙

. Here we explore the level of tension between El Gordo and ΛCDM for the new mass estimate, assuming several V
infall values. We find that in order to reduce the tension below the 5σ level, the El Gordo subclusters should have V
infall < 2300 km s−1 (V
infall < 1800 km s−1 when considering the combined tension with the Bullet Cluster). To the best of our knowledge, the El Gordo hydrodynamical simulations conducted so far require V
infall ≥ 2500 km s−1 to simultaneously reproduce its morphology and its high X-ray luminosity and temperature. We therefore conclude that El Gordo still poses a significant challenge to ΛCDM cosmology. Whether the properties of El Gordo can be reconciled with a lower V
infall should be tested with new hydrodynamical simulations that explore different configurations of the interaction.
La sortie du marché du travail des personnes en couple et de leurs conjoints
Authors: Abbas Hicham , Martin Henri 
Published: September 2023

La question de la sortie du marché du travail est centrale en économie pour comprendre les dynamiques de la population active. Elle est incontournable pour le législateur, qui cherche, depuis les années 1990, à repousser l’âge de la retraite par diverses mesures (décalage de l’âge légal d’ouverture des droits, augmentation de la durée d’assurance requise pour une pension à taux plein, extinction des dispositifs de cessation précoce d’activité, etc.). Or, cette sortie intervient à un moment où la plupart des individus vivent en couple et où la situation du conjoint joue nécessairement un rôle. Cette contribution exploratoire cherche à documenter la sortie du marché du travail au sein des couples. L’enquête Emploi de l’Insee, qui interroge un échantillon d’individus et leurs conjoints, permet de dresser un panorama de la situation des couples aux âges qui correspondent à la sortie du marché du travail. Sa profondeur historique renseigne également sur la dynamique en longue période de ces situations, tenant ainsi compte de la progression de l’activité féminine au fil des générations. Les données de l’échantillon démographique permanent de l’Insee, enrichies depuis peu des données fiscales, assurent par ailleurs un suivi longitudinal des couples sur la période de 9 ans allant de 2010 à 2018. Ces données rendent donc possible la construction de « parcours types » de sortie du marché du travail au sein des couples en mobilisant une méthode d’appariement optimal. Neuf parcours se dégagent pour les hommes nés en 1952, contre huit pour les femmes nées cette même année. Ils aident à mieux comprendre les situations des individus en couple au moment de la fin de la vie active.
Vieillissement au travail et handicap : quand la structure organisationnelle s’immisce dans les parcours
Authors: Burnay Nathalie , Pierre Amélie 
Published: September 2023

En 1995, les entreprises de travail adapté (ETA) voient le jour en Belgique. Ces lieux doivent permettre une inclusion sur le marché du travail des personnes en situation de handicap. Les parcours professionnels se construisent au fil du handicap, mais également en fonction du positionnement de l’ETA sur un continuum organisationnel qui oscille entre bienveillance et productivité. Cette enquête qualitative réalisée dans un ETA en Belgique francophone montre combien le vieillissement au travail ne peut se résumer à une question d’âge, mais doit être considéré de manière complexe en tenant compte de l’ensemble du parcours de vie ainsi que des structures organisationnelles dans lesquelles ils prennent place. Les récentes transformations du secteur risquent bien de renforcer les contraintes de rentabilité et conduire de facto à un risque accru de sortie prématurée de l’emploi de cette population déjà fragilisée.
Neural therapy in physiatric settings
Authors: Sankaran Ravi 
Published: September 2023

Abstract
The algorithmic approach modern medicine uses to diagnose and treat illness has helped it spread rapidly and control responsive ailments. On the other hand, a fair number of problems originate from within the person suffering (as opposed to lifestyle or genetic issues). Some of these manifest in ways that take a person through all the constituent investigations and treatments provided by modern medicine only to end up with a diagnosis that is otherwise taken as untreatable. While the clinicians involved are safe, having followed the evidence-based guidelines, the patient continues to live and suffer. Another set of problems prevails in healthcare. While modern medicine can save lives, once that life is saved, very few are aware of what to do next. Most clinicians either do not know what physiatry is, or assume it is physiotherapy. When families ask “What next,” the most common responses are go home and take care of the patient (wash the hands off), do whatever you want (put responsibility on the family), and get some physiotherapy (when not medically supervised is close to quackery). As the health condition (not the person) has been treated as much as possible, these responses are not wrong. Nor are they helpful to the patient/family. A subsection of these issues may be psychosomatic in nature and not controlled with the three mentioned modalities. This is where interventions such as neural therapy can help.
Survival analysis: A primer
Authors: Anila Kutty Narayanan , Saraswathy Sivaprasadan , Sudhindran Surendran , Valsan Arun 
Published: September 2023

Abstract
Survival analysis is an important time-bound statistical tool used in medical research to gather valuable insights into outcomes, treatment efficacy, and disease progression. This tool employs various models to run the data such as Cox proportional hazards ratio, life tables, Kaplan–Meier estimates among others. This write-up highlights various survival analysis techniques that are used to estimate time to event in research. This article provides insights into the general concepts and a few important tools of survival analytics to the readers.
Real-world data on incidence of frailty in cardiac surgical patients and its impact on quality of life: An observational feasibility study
Authors: Madathil Thushara , Jayanth Aveek , Jose Reshmi Liza , Shubha Kattil S 
Published: September 2023

Abstract

Background:
An improvement in quality of life (QOL) is increasingly being perceived as a quality indicator after surgical interventions, cardiac surgery being no exception. There is scarce literature on whether frailty alters this expected change in QOL.

Objective:
To assess the baseline frailty and QOL of cardiac surgical patients and the impact of frailty on the QOL patterns in the cardiac surgical population presenting to a tertiary care facility in south India.

Materials and Methods:
Prospective observational pilot study. Of the 60 patients recruited, 41 patients were assessed for baseline frailty and 37 for change in QOL 3 months after cardiac surgery. Frailty was assessed using the Fried frailty test. Baseline QOL and QOL after 3 months of surgery were calculated with the Short Form-36 questionnaire under its eight domains.

Results:
The median values of QOL among cardiac surgical patients are 50 and 66, respectively, for role limitation due to physical health and role limitation to emotional health, as against above 70 each in the community. Other domains of QOL were comparable with the general population. There is no change in QOL noted in the nonfrail 3 months after cardiac surgery. The frail showed an improvement in the domain of general health. Prefrail showed an improvement in domains of pain and general health but a decline in physical and emotional well-being after cardiac surgery.

Conclusion:
Though this is a pilot study and will be followed by a future larger study, it still does give the following clues: QOL scores in cardiac patients are lower than in the general population, and the frail benefit from cardiac surgery as it improves their QOL.
The Structural Relationships Between Quality of Life and Mental Conditions in Stoma Patients
Authors: Narumi Momoka , Nishimori Hidefumi , Hasegawa Masaru , Hazawa Yuri , Ishinuki Tomohiro , Goda Erika , Hata Fumitake , Kihara Chikashi , Okita Kenji , Ohyanagi Toshio , Hui Thomas T. , Mizuguchi Toru 
Published: September 2023

Background:
Peristomal wounds have a remarkable negative impact on the quality of life (QOL), including the social activities, of stoma patients. Although the number of stoma patients is increasing, the relationship between peristomal disorders and QOL is not widely understood.

Objectives:
The aim of this study was to elucidate the relationship between the QOL status of stoma patients and the condition of the peristomal skin through structural equation modeling (SEM), which could help provide a comprehensive overview of the factors affecting the health of such patients.

Design:
Observational study of prospectively collected data.

Setting:
This study was conducted in the colorectal unit of two educational hospitals in Sapporo, Japan.

Patients and Methods:
Outpatient patients with a stoma were recruited between July 11, 2019 and November 30, 2019. The relationship among the clinical variables were identified using SEM analysis.

Sample Size:
Sixty-seven consecutive stoma patients.

Main Outcome Measures:
The Ostomy Skin Tool [used to assess the discoloration, erosion, and tissue overgrowth (DET) score], Stoma-QOL, Hospital Anxiety and Depression Scale (HADS), and the EQ-5D-5L questionnaire were employed.

Results:
The observation period in the low DET score group was longer than that in the high DET score group. An SEM-derived path diagram, which exhibited high goodness-of-fit indices, revealed the relationships among the clinical factors. Patient satisfaction was positively associated with the Stoma-QOL score and negatively associated with the HADS-anxiety score but not the HADS-depression score.

Conclusions:
Peristomal skin disorders did not affect QOL or mental health status. The QOL scores of the patients with mild peristomal skin disorders markedly varied. Anxiety, but not depression, reduced the satisfaction of stoma patients and was alleviated over time.

Limitations:
A cross-sectional observational study cannot be used to precisely determine causal relationships.

Conflict of Interest:
The authors have no conflict of interest to declare.
Long-Term Quality of Life after Acute Uncomplicated Diverticulitis: A Cross-Sectional Study
Authors: Azzawi Yara , Azhar Najia , Jörgren Fredrik , Schultz Johannes , Buchwald Pamela 
Published: September 2023

Background:
Diverticulitis is a common medical condition that usually affects older patients. Antibiotic therapy in patients with acute uncomplicated diverticulitis (AUD) has been questioned. Currently, there is limited data on the quality of life (QoL) of patients after AUD.

Objectives:
The aim of this study was to investigate the long-term QoL in patients with AUD and to assess if antibiotic therapy or recurrent disease impacts the QoL of patients.

Design:
Cross-sectional questionnaire study.

Setting:
Two teaching hospitals in Southern Sweden.

Patient and Methods:
The records of patients who were treated for AUD from 2015 to 2017 were extracted, and their medical charts were used to gather data. Three questionnaires (EuroQol-5 Dimension-5L, the Gastrointestinal Quality of Life Index, and the short health scale) were sent 3–5 years after hospitalization (year 2020) to evaluate the QoL of the patients.

Main Outcome Measure:
Long-term QoL measured by the aforementioned questionnaires.

Sample Size:
The original cohort was reduced to 509 due to death, duplications, and sigmoid colectomy. The final patient cohort consisted of 273 patients after exclusion of non-responders or patients who declined participation.

Results:
In the EuroQol-5 Dimension scale, 147 (55%) patients reported problems in one or more QoL dimension but only 4% experienced severe problems. The Gastrointestinal Quality of Life Index median score was 105.0 (90.0–113.8), while the median short health scale score was 4.0 (0.9–12.5). Among the patients, 76% were treated with antibiotics, but no differences were observed between the antibiotics and no antibiotics groups in any QoL score. Recurrent disease was associated with lower QoL scores.

Conclusion:
This study showed that 161 (59%) of the patients with AUD experienced QoL problems, with recurrent disease being a risk factor. Antibiotic therapy did not affect the long-term QoL of the patients. Larger prospective studies are needed to confirm these results, and future efforts should be made to prevent the recurrence of AUD.

Limitations:
Limited sample size, non-randomized study.

Conflict of Interest:
The authors have no conflict of interest to declare.
Genome assembly and annotation of the Sharp-nosed Pit Viper Deinagkistrodon acutus based on next-generation sequencing data
Authors: Wang Xinyu , Liu Lirong , Zhu Wenbiao , Wang Shiqing , Shi Minhui , Yang Shuhui , Lu Haorong , Cao Jun 
Published: September 2023

The study of the currently known >3,000 species of snakes can provide valuable insights into the evolution of their genomes. Deinagkistrodon acutus, also known as Sharp-nosed Pit Viper, one hundred-pacer viper or five-pacer viper, is a venomous snake with significant economic, medicinal and scientific importance. Widely distributed in southeastern China and South-East Asia, D. acutus has been primarily studied for its venom. Here, we employed next-generation sequencing to assemble and annotate a highly continuous genome of D. acutus. The genome size is 1.46 Gb; its scaffold N50 length is 6.21 Mb, the repeat content is 42.81%, and 24,402 functional genes were annotated. This study helps to further understand and utilize D. acutus and its venom at the genetic level.
The client’s consent strengthens the ‘Gamers’ hand; The deterrence theory’s perspective of the Internet romance fraudsters.
Authors: Toku Lomatey , Otu Offei Martin 
Published: September 2023

Internet romance fraud (IRF) is an international crime which has great consequences for individuals, businesses and nations. This emerging crime is based on a romantic love relationship over the internet between a victim (with love intention) and an offender with a criminal intention. Offenders recruit victims from dating sites with the sole intention of defrauding these victims by deception. This study surveyed 320 respondents from validated internet romance fraud (IRF) hotspots which includes, internet cafés and university campuses in Ghana. Structural equation modelling (SEM), with partial least square (PLS) was use to model and analyze the casual relationships of the dependent and independent variables. The evidence from this study suggests, deterrence - dimensions of punishment (certainty, severity) and shame (certainty severity) negatively influence intention to commit internet romance fraud (IRF) however, intention to commit internet romance fraud (IRF) positively influence the actual IRF crime. Whereas, punishment dimensions are negative and significant, shame dimensions are negative and insignificant, implying IRF are not shamed in their quest to defraud their victims. Internet romance fraudsters are not deterred by punishment and or shame to defraud their victims, although they know their acts are criminal in nature and punishable by law. Offenders’ criminal intention ensures that victims are ultimately defrauded under the pretense of romantic love relationship. This embolden attitude of internet romance offenders must inform law enforcement and prosecutions. Maybe the punishment meted to IRF criminals are not deterrent enough, thereby, sending the wrong signals to IRF criminals and encouraging more young persons to participate in internet romance fraud (IRF) activities.
A Universidade Pública Brasileira: a ofensiva privatista como ideologia
Authors: Martins do Nascimento Clara , Simionatto Ivete 
Published: September 2023

Este artigo se propõe a refletir sobre o poder material do discurso da privatização presente no ensino superior brasileiro, em programas governamentais, e de que modo se materializa como ideologia. Trabalha com a hipótese de que tal discurso desempenha uma função social frente à consolidação de um projeto privatista para o ensino superior brasileiro, alinhado às exigências do capitalismo em sua fase financeirizada. Através dos pressupostos teórico-metodológicos da teoria social crítica marxiana e marxista enquanto ferramentas de análise, conclui que a ofensiva ideológica proferida pelos diferentes governos, marcada pelo aceleramento da implementação de um novo projeto de universidade, porta uma base material. Isto porque, as ideologias imprimem direção aos conflitos sociais e conferem materialidade a projetos educacionais com interesses determinados.
АҚШ ИҚТИCОДИЁТИНИНГ ИННОВАЦИОН ТИЗИМИ ОМИЛЛАРИ, ТАРКИБИ ВА РИВОЖЛАНИШ НАЗАРИЯCИ
Authors: Шакирова Фaрoғaт 
Published: September 2023

Мaзкур мaқoлaдa Aмерикa қўшмa штaтлaри миллий иннoвaция тизими вa oмиллaри aтрoфличa ёритиб берилган ва Ўзбекистон иқтисодиётига жорий қилиш бўйича таклифлар берилган.. Шунингдек, мaмлaкaтнинг иннoвaциoн ривoжлaнишгa ўтиш эвoлюцияcи ёритиб берилгaн ҳамда олий ўқув юртлари-фан-капитал ва ишлаб чиқариш интеграциясини таъминлаб берадиган технологик парклар тажрибаси ўрганилган.
FARZONA XO‘JANDIY SHE’RLARIDA MIFOLOGIK PERSONAJLAR BADIIY IFODASINING ХUSUSIYATLARI
Authors: Mirzoyev Masudjon , Niholchonova Navbahor 
Published: September 2023

Mazkur maqolada Tojikiston xalq shoiri Farzonai Xo‘jandiy she’rlarida mifologik personajlar badiiy ifodasining xususiyatlari tadqiq qilinadi. Shoiraning mifologik personajlarning shoirona san'at va mahorat ila yangicha talqin etganligini o‘rganish asosiy maqsad etib belgilandi.
OLIY TA’LIM MUASSASASI TALABALARIDA LIDERLIK SIFATLARINI SHAKLLANTIRISH BOSQICHLARI
Authors: Qodirov Xasanboy 
Published: September 2023

Ushbu maqolada oliy ta’lim muassasasi talabalarida liderlik sifatlarini shakllantirish bosqichlari va uning ta`lim sifatini oshirishdagi o`rni va ahmiyati haqida muhokama qilinadi va kerakli yavsiyalar taqdim etiladi
OLIY TA’LIM MUASSASALARIDA MASOFAVIY TA’LIM MAZMUNI VA TA’LIM JARAYONINI TAKOMILLASHTIRISHNING DIDAKTIK – USLUBIY TA’MINOTI
Authors: Axmadjonova Farangiz 
Published: September 2023

O’qish va o’rganish bu insonning mukammal bo’lishga intilishining boshlanishidir. Shunisi ma’lumki, ilm va bilim qanchalik rivojlangan bo’lsa, ilm olishni o’rganish va metodlarini o’zgartirish uchun ko’proq ehtiyoj talab etiladi. Bugungi kunda masofaviy ta’lim eng muqobil yo’nalishlardan biri bo’lib, uni yuzma-yuz yoki an’anaviy ta’lim bilan almashtirish mumkin va bu oliy ta’limning rivojlanishidagi ustuvor yunalishlaridan biridir. Masofaviy ta’limni buyuk olim Xolmberg, uzluksiz ta’lim deb ta’riflaydi. Darhaqiqat, bunda uqituvchi va talaba makon va zamonga nisbatan bir-biridan ajralib turadi va bu uning asosiy xususiyatlaridan biri hisoblanadi. Ushbu maqolada ham masofaviy uqitishning ahamiyati afxalliklari bilan bir qatorda uning pedagigik, didaktik uslubiy ta’minoti haqida to’xtalinadi.
Comparison of 99mTc-HMPAO-labeled leukocyte scintigraphy findings with systemic inflammatory markers
Authors: ERTÜRK Seyit Ahmet , HASBEK Zekiye 
Published: September 2023

Aims: Technetium-99m-hexamethylpropylene amine oxime (99mTc-HMPAO) labeled leukocyte scintigraphy is frequently used for infection imaging. The systemic immune-inflammation index is a new marker. In this study, we aim to investigate the relationship between 99mTc-HMPAO-labeled leukocyte scintigraphy findings and systemic inflammatory markers such as Neutrophil/lymphocyte ratios (NLR) and Platelet lymphocyte ratio (PLR) and systemic immune-inflammation index (SII).
Methods: Patients who underwent 99mTc-HMPAO-labeled leukocyte scintigraphy between 2014 and 2020 due to suspected infection such as diabetic foot infection or prosthesis infection vs. in any part of the body were included in our study. In addition, a negative control group consisting of 19 normal subjects who had no leukocyte scintigraphy and had hemogram examination was added to the study. Cases with findings consistent with infection in labeled leukocyte scintigraphy and infectious symptoms in this area of involvement in the clinical examination were considered as the positive group. The data were evaluated with the SPSS 23.0 program.
Results: Our study included 36 patients (28 males,8 females, mean age: 59.7). The mean SII was 1526±787 x109 cells/L in patients with positive findings in leukocyte scintigraphy that might be compatible with infection, while it was 1025 ± 370 x109 cells/L in patients who did not (p=0.017). The mean PLR was 183.95±68.30 in patients with positive findings in leukocyte scintigraphy that might be compatible with infection, while it was 145.81±58.30 in patients who did not (p=0.102). The mean NLR was 4.82±1.91 in patients with positive findings on leukocyte scintigraphy that might be compatible with infection, while it was 4.15±1.40 in patients who did not (p=0.181). While the negative control group and the patients who were considered positive in leukocyte scintigraphy were compared; a statistically significant difference was found between SII, NLR and PLR values. When the relationship between SII was evaluated, the mean SII was 1526±787 x109 cells/L in patients with involvement that may be compatible with infection in leukocyte scintigraphy, while it was 762±224 x109 cells/L in the negative control group (p