bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opening of hotels and ski facilities: Impact on mobility, spending, and Covid‐19 outcomes
Authors: Zaremba Krzysztof 
Published: February 2023

AbstractThis paper investigates how reopening hotels and ski facilities in Poland impacted tourism spending, mobility, and COVID‐19 outcomes. We used administrative data from a government program that subsidizes travel to show that the policy increased the consumption of tourism services in ski resorts. By leveraging geolocation data from Facebook, we showed that ski resorts experienced a significant influx of tourists, increasing the number of local users by up to 50%. Furthermore, we confirmed an increase in the probability of meetings between pairs of users from distanced locations and users from tourist and non‐tourist areas. As the policy impacted travel and gatherings, we then analyzed its effect on the diffusion of COVID‐19. We found that counties with ski facilities experienced more infections after the reopening. Moreover, counties strongly connected to the ski resorts during the reopening had more subsequent cases than weakly connected counties.
The Skewness‐Kurtosis plane for cryptocurrencies' universe
Authors: Karagiorgis Ariston , Ballis Antonis , Drakos Konstantinos 
Published: February 2023

AbstractCryptocurrency returns diverge excessively from normality, with the interrelationship of Skewness and Kurtosis being accordant with a parabolic form, yet this connection is scantly documented. We begin by demonstrating diagrammatically the attributes of the S‐K plane for cryptocurrencies. Moreover, by taking advantage of the panel structure of the data, we estimate a quadratic model for the S‐K plane. Then we investigate whether the type and the infrastructure of the cryptocurrency, as well as the period under examination, alter the architecture of the plane. We find that the squared Skewness of tokens substantially lowers the slope of Kurtosis, while the same applies to the earlier era of the market.
Photoisomerization of linear merocyanines in salt solutions
Authors: Wu Ping‐Chien , Tan Kui‐Thong , Chen I‐Chia 
Published: February 2023

AbstractThe trans‐cis isomerization in the excited state of linear merocyanine L‐Mero4 and phenyl substituted linear merocyanine P‐L‐Mero4 in salt solution and in ionic liquid was investigated using frequency upconversion measurements. Strontium chloride and cesium iodide were added to solvent dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) to vary the ionic strength. The time‐resolved fluorescence curves of merocyanines displayed multiple exponential decay behavior. The second temporal component with time constant τ2 ≈ 2.8 (11) ps of L‐Mero4 (P‐L‐Mero4) in DMSO was assigned to the duration to reach the isomerization equilibrium between the trans and the twisted conformers. The τ2 increased at higher salt concentrations and was explained by the attachment of salt ions on the polar excited merocyanines decelerating the isomerization rate. The rotational correlation time constants obtained from the anisotropy decay of fluorescence were 360 and 240 ps in neat DMSO for L‐Mero4 and P‐L‐Mero4, respectively, and they increased to 790 and 450 ps in the most concentrated SrCl2. Using Perrin relation, we estimated the increase in the rotating volume at [SrCl2] = 536 mM, revealing ≈15 SrCl2 molecules surrounding L‐Mero4 and 7 SrCl2 on P‐L‐Mero4. The experimental data indicated that the ion–molecule interaction was stronger with SrCl2 and on L‐Mero4 than on P‐L‐Mero4.
Green catalyst access to thieno [2, 3‐b] pyridines derivatives
Authors: Mehaoui Nawel , Boudjema Souheyla , Kibou Zahira , Choukchou‐Braham Noureddine , Choukchou‐Braham Abderrahim 
Published: February 2023

AbstractThe current study focuses on the use of tungstovanadophosphoric heteropoly acid H4PW11VO40·8 H2O (PVW) with Keggin structure and supported on acid activated (PVW/AAM) in the synthesis of new substituted Thieno [2, 3‐b] pyridines derivatives. The suggested protocol is an easy, environmentally friendly method for synthesis of thieno [2,3‐b] pyrimidine derivatives obtained from 3‐cyano‐2‐aminothiophene as building blocks under solvent‐free reactions condition. Excellent product yields of substituted Thieno [2, 3‐b] pyridine derivatives (60%–97%) were achieved using the synthesized PVW/AAM catalyst. The current processes provide benefits including a quicker reaction time, an easy set‐up, and high yields. Spectroscopic data (IR, +H and 13C NMR spectra) have revealed the structural details of all target compounds. The catalyst was characterized by X‐ray diffraction, BET and Fourier‐transformed infrared spectroscopy. X‐ray diffraction showed that PVW was correctly incorporated on an acid activated clays support. In comparison to the parent, Tungstovanadophosphoric acid, the PVW supported acid activated montmorillonite provided increased Lewis acid site density, redox characteristics, and surface area. Due to the recoverability of heterogeneous catalysts, the heterogenization of homogeneous catalysts is very attractive. In addition, the produced catalysts can be simply removed from the reaction system and reused six times more effectively.
Pregnancy, delivery, and postpartum period in infantile liver failure syndrome type 2 due to variants in NBAS
Authors: Peters Bianca , Wiemers Felix , Lenz Dominic , Kölker Stefan , Hoffmann Georg F. , Köhler Siegmund , Staufner Christian 
Published: February 2023

AbstractBiallelic pathogenic variants in the neuroblastoma amplified sequence (NBAS) gene affecting the Sec39 domain are associated with a predominant hepatic phenotype named infantile liver failure syndrome type 2 (ILFS2). Individuals are at risk of developing life‐threatening acute liver failure episodes, most likely triggered by febrile infections. Pregnancy, delivery, and the postpartum period are well known triggers of decompensation in different inherited metabolic diseases and therefore entail a potential risk also for individuals with ILFS2. We studied pregnancy, birth, and postpartum period in a woman with ILFS2 (homozygous for the NBAS variant c.2708 T > G, p.(Leu903Arg)). During two pregnancies there were no complications associated with the underlying genetic condition. Two healthy boys were born by cesarean section. To reduce the risk of fever and febrile infections, we avoided prolonged labor, epidural analgesia, and breastfeeding. Maternal body temperature and liver function were closely monitored. In case of elevated body temperature, antipyretic treatment (acetaminophen, metamizole) was given without delay. Alanine and aspartate aminotransferases as well as liver function remained normal throughout the observation period. Hence, pregnancy and childbirth are feasible in women with ILFS2 under careful monitoring.
Evolution of homology: From archetype towards a holistic concept of cell type
Authors: Rusin Leonid Y. 
Published: February 2023

AbstractThe concept of homology lies in the heart of comparative biological science. The distinction between homology as structure and analogy as function has shaped the evolutionary paradigm for a century and formed the axis of comparative anatomy and embryology, which accept the identity of structure as a ground measure of relatedness. The advent of single‐cell genomics overturned the classical view of cell homology by establishing a backbone regulatory identity of cell types, the basic biological units bridging the molecular and phenotypic dimensions, to reveal that the cell is the most flexible unit of living matter and that many approaches of classical biology need to be revised to understand evolution and diversity at the cellular level. The emerging theory of cell types explicitly decouples cell identity from phenotype, essentially allowing for the divergence of evolutionarily related morphotypes beyond recognition, as well as it decouples ontogenetic cell lineage from cell‐type phylogeny, whereby explicating that cell types can share common descent regardless of their structure, function or developmental origin. The article succinctly summarizes current progress and opinion in this field and formulates a more generalistic view of biological cell types as avatars, transient or terminal cell states deployed in a continuum of states by the developmental programme of one and the same omnipotent cell, capable of changing or combining identities with distinct evolutionary histories or inventing ad hoc identities that never existed in evolution or development. It highlights how the new logic grounded in the regulatory nature of cell identity transforms the concepts of cell homology and phenotypic stability, suggesting that cellular evolution is inherently and massively network‐like, with one‐to‐one homologies being rather uncommon and restricted to shallower levels of the animal tree of life.
Impacts of Early Holocene environmental dynamics on open‐air occupation patterns in the Western Mediterranean: insights from El Arenal de la Virgen (Alicante, Spain)
Authors: Fernández‐López De Pablo Javier , Polo‐Díaz Ana , Rabuñal José Ramón , Gómez Puche Magdalena , Carrión Marco Yolanda , Cantó Ana , Mclaughlin Rowan , Ferrer Carlos , Burjachs Francesc 
Published: February 2023

ABSTRACTOpen‐air sites represent a fundamental proxy of the Early Holocene adaptive systems in the Iberian Peninsula. However, its research potential for the study of human–environmental interactions has been minimally explored. In this work, we present the results of an integrated research programme focused on open‐area excavations at the Mesolithic site of Arenal de la Virgen (Alicante, Spain). Novel multi‐scalar geoarchaeological and archaeo‐stratigraphic studies, coupled with featured‐based palaeobotanical analysis, were used to design an extensive radiocarbon dating programme and produce different Bayesian chronological models. Our results distinguish two different Mesolithic occupation phases, dating to 9.3–9.1 and 8.6–8.3k cal a bp respectively, consisting of combustion features and lithic scatters. The comparison of occupational dynamics with the nearby palaeoecological records of Salines and Villena indicated that both Mesolithic phases occurred under relatively stable environmental conditions. The second Mesolithic phase, however, ended during the onset of the 8.2k cal a
bp climatic event, when sedimentation processes shifted from soil formation to accretion of aeolian sands. We demonstrate that the end of the Mesolithic occupations at Arenal de la Virgen coincides with the cessation of radiocarbon‐dated activity in other open‐air Postglacial sites in the central Mediterranean region of Iberia.
Comparison of surgeon and pathologist total mesorectal excision grade after rectal cancer resection: A single institution analysis
Authors: Kato Patrick J. , Kanters Arielle E. , Rivard Samantha J. , Hendren Samantha , Ramm Carole , Albright Jeremy , Schumaker Kate E. , Cleary Robert K. 
Published: February 2023

AbstractBackgroundA Michigan Surgical Quality Collaborative Colorectal Cancer Project initiative sought to increase adoption of surgeon total mesorectal excision (TME) grading through standardized education and synoptic operative reporting. Our study aim was to assess initiative impact and level of agreement between surgeon and pathologist‐determined TME grades.MethodsThis is a retrospective comparison of surgeon and pathologist TME grades before and after initiative implementation using a prospectively maintained enhanced recovery colorectal surgery database.ResultsThere were 112 TMEs before, and 53 TMEs following initiative implementation. There was a significant increase in surgeon TME‐grade reporting in the postinitiative period (25.0% pre‐ vs. 81.1% post‐, p < 0.001). Pathologist TME‐grade reporting was high in both time periods and there was no significant change (91.1% pre‐ vs. 88.7% post‐, p = 0.84). Surgeon and pathologist agreement was 59.3% in the preinitiative period (Κ “minimal”   0.356) and 65.0% in the postinitiative period (Κ “moderate” = 0.605, p = 0.827). There was no significant association between clinical T‐stage and surgeon or pathologist TME grade.ConclusionSurgeon TME grading improves with education and synoptic operative reporting. There is only moderate agreement between surgeon and pathologist, a finding that requires further study. Organized regional initiatives are effective at implementing rectal cancer management quality improvement.
An Injectable Integration of Autologous Bioactive Concentrated Growth Factor and Gelatin Methacrylate Hydrogel with Efficient Growth Factor Release and 3D Spatial Structure for Accelerated Wound Healing
Authors: Zhang Lixiang , Yuan Zhengchao , Shafiq Muhammad , Cai Youjun , Wang Zewen , Nie Piming , Mo Xiumei , Xu Yuan 
Published: February 2023

AbstractGrowth factors are essential for wound healing owing to their multiple reparative effects. Concentrated growth factor (CGF) is a third‐generation platelet extract containing various endogenous growth factors. Herein, a CGF extract solution is combined with gelatin methacrylate (GM) by physical blending to produce GM@CGF hydrogels for wound repair. The GM@CGF hydrogels show no immune rejection during autologous transplantation. Compared to CGF, GM@CGF hydrogels not only exhibit excellent plasticity and adhesivity but also prevent rapid release and degradation of growth factors. The GM@CGF hydrogels display good injectability, self‐healing, swelling, and degradability along with outstanding cytocompatibility, angiogenic functions, chemotactic functions, and cell migration‐promoting capabilities in vitro. The GM@CGF hydrogel can release various effective molecules to rapidly initiate wound repair, stimulate the expressions of type I collagen, transform growth factor β1, epidermal growth factor, and vascular endothelial growth factor, promote the production of granulation tissues, vascular regeneration and reconstruction, collagen deposition, and epidermal cell migration, as well as prevent excessive scar formation. In conclusion, the injectable GM@CGF hydrogel can release various growth factors and provide a 3D spatial structure to accelerate wound repair, thereby providing a foundation for the clinical application and translation of CGF.
Graded filtrations and ideals of reduction number 2
Authors: Kumashiro Shinya 
Published: February 2023

AbstractIn this paper, we give a way to construct graded filtrations of graded modules. We then apply it to the Sally module, which describes a correction term of the Hilbert function. As a result, we obtain the inequality of the Hilbert coefficients for ideals of reduction number 2 or 3.
Frequency and type of cancers in myotonic dystrophy: A retrospective cross‐sectional study
Authors: D'Ambrosio Eleonora S. , Chuang Kathy , David William S. , Amato Anthony A. , Gonzalez‐Perez Paloma 
Published: February 2023

AbstractIntroduction/AimsMyotonic dystrophies (DMs) are autosomal dominant diseases in which expression of a mutant expanded repeat mRNA leads to abnormal splicing of downstream effector genes thought to be responsible for their multisystem involvement. Cancer risk and cancer‐related deaths are increased in DM patients relative to the general population. We aimed at determining the frequency and type of cancers in both DM1 and DM2 vs a non‐DM muscular dystrophy cohort.MethodsA retrospective, cross‐sectional study was carried out on patients with genetically confirmed DM1, DM2, facioscapulohumeral muscular dystrophy (FSHD), and oculopharyngeal muscular dystrophy (OPMD) at our institutions from 2000 to 2020.ResultsOne hundred eighty‐five DM1, 67 DM2, 187 FSHD, and 109 OPMD patients were included. Relative to non‐DM, DM patients had an increased cancer risk that was independent of age and sex. Specifically, an increased risk of sex‐related (ovarian) and non–sex‐related (non‐melanoma skin, urological, and hematological) cancers was observed in DM1 and DM2, respectively. The length of CTG repeat expansion was not associated with cancer occurrence in the DM1 group.DiscussionIn addition to current consensus‐based care recommendations, our findings prompt consideration of screening for skin, urological, and hematological cancers in DM2 patients, and screening of ovarian malignancies in DM1 female patients.
Patients' perceived challenges, competencies, and supportive care needs during acute clinical treatment of breast or gynecological cancer
Authors: Fahmer Natascha , Faller Hermann , Wöckel Achim , Salmen Jessica , Heuschmann Peter U. , Meng Karin 
Published: February 2023

AbstractObjectiveThis study aimed to examine challenges, competencies, and supportive care needs (SCN) of women with breast or gynecological cancer during acute cancer treatment and associations to other health‐related variables.MethodsWe surveyed 120 patients with breast or gynecological cancer at the end of acute cancer treatment, either directly after surgery or during adjuvant chemotherapy. We assessed challenges, subjective competencies, and SCN using a self‐developed measure comprising 25 items referring to coping tasks assigned to six domains. In addition, patients' competencies and health literacy (HL) were assessed.ResultsMost patients felt at least moderately challenged by coping tasks concerning psychological distress (e.g., dealing with fears and insecurities, 70.2%; coping with cancer diagnosis, 69.6%) and physical complaints (e.g., dealing with a reduced physical capacity, 56.6%). About 42.5%–71.4% of patients who evaluated coping tasks as highly challenging felt competent to deal with these challenges themselves. Less than half of patients reported SCN, mainly regarding psychological concerns. The extent of challenging coping tasks, patients' perceived ability to overcome challenges themselves, and SCN showed associations to patient competencies and HL.ConclusionsSCN regarding psychological concerns and health behavior should be addressed in acute cancer care and rehabilitation programs. In addition, promoting HL might be essential in strengthening patients' subjective competencies related to various coping tasks.
Integrative structural analysis of the type III secretion system needle complex from Shigella flexneri
Authors: Flacht Lara , Lunelli Michele , Kaszuba Karol , Chen Zhuo Angel , Reilly Francis J. O'. , Rappsilber Juri , Kosinski Jan , Kolbe Michael 
Published: February 2023

AbstractThe type III secretion system (T3SS) is a large, transmembrane protein machinery used by various pathogenic gram‐negative bacteria to transport virulence factors into the host cell during infection. Understanding the structure of T3SSs is crucial for future developments of therapeutics that could target this system. However, much of the knowledge about the structure of T3SS is available only for Salmonella, and it is unclear how this large assembly is conserved across species. Here, we combined cryo‐electron microscopy, cross‐linking mass spectrometry, and integrative modeling to determine the structure of the T3SS needle complex from Shigella flexneri. We show that the Shigella T3SS exhibits unique features distinguishing it from other structurally characterized T3SSs. The secretin pore complex adopts a new fold of its C‐terminal S domain and the pilotin MxiM[SctG] locates around the outer surface of the pore. The export apparatus structure exhibits a conserved pseudohelical arrangement but includes the N‐terminal domain of the SpaS[SctU] subunit, which was not present in any of the previously published virulence‐related T3SS structures. Similar to other T3SSs, however, the apparatus is anchored within the needle complex by a network of flexible linkers that either adjust conformation to connect to equivalent patches on the secretin oligomer or bind distinct surface patches at the same height of the export apparatus. The conserved and unique features delineated by our analysis highlight the necessity to analyze T3SS in a species‐specific manner, in order to fully understand the underlying molecular mechanisms of these systems. The structure of the type III secretion system from Shigella flexneri delineates conserved and unique features, which could be used for the development of broad‐range therapeutics.
Approximately counting independent sets in bipartite graphs via graph containers
Authors: Jenssen Matthew , Perkins Will , Potukuchi Aditya 
Published: February 2023

AbstractBy implementing algorithmic versions of Sapozhenko's graph container methods, we give new algorithms for approximating the number of independent sets in bipartite graphs. Our first algorithm applies to ‐regular, bipartite graphs satisfying a weak expansion condition: when is constant, and the graph is a bipartite ‐expander, we obtain an FPTAS for the number of independent sets. Previously such a result for was known only for graphs satisfying the much stronger expansion conditions of random bipartite graphs. The algorithm also applies to weighted independent sets: for a ‐regular, bipartite ‐expander, with fixed, we give an FPTAS for the hard‐core model partition function at fugacity . Finally we present an algorithm that applies to all ‐regular, bipartite graphs, runs in time , and outputs a ‐approximation to the number of independent sets.
Sense of community and anxiety during a global pandemic: The role of world assumptions in couples
Authors: Witting Alyssa Banford , Busby Dean M. , Allen Emma 
Published: February 2023

AbstractThe current study was designed to examine the role of sense of community at the outset of COVID‐19 pandemic‐related shutdowns as a longitudinal predictor of anxiety in couples. We also sought to investigate whether self‐reported changes in perceived levels of benevolent world assumptions would serve as an indirect conveyor of this association. Data were collected at three time points during the first 6‐months of pandemic shutdowns in the US and the current study utilized responses from 535 heterosexual cisgender couples. Mplus was used to path model lagged associations between sense of community at wave 1, world assumptions at waves 1 and 2 and anxiety symptoms at all three waves for both partners. Findings demonstrated direct effects within men and women with a stronger sense of community at wave 1 relating to lower anxiety at waves 2, and within women this effect extended to wave 3. Further, we found that a higher sense of community at wave 1 in men associated with perceived strengthening of benevolent world assumptions at the next wave for men and women. We noted that perceived strengthened benevolent world assumptions at wave 2 associated with lower anxiety at wave 3 within men. Indirect effects showed that a stronger sense of community at wave 1 associated with lower anxiety at wave 3 within men.