bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of the Photoluminescence Enhancement Observed in ZnO Nanowire Gratings Optimally Grown by the Hydrothermal Method
Authors: Martin Aubry , Potdevin Audrey , Réveret François , Centeno Emmanuel , Smaali Rafik , Omeis Fatima , Riassetto David , Kachan Elena , Jourlin Yves , Chadeyron Geneviève , Langlet Michel 
Published: July 2023

AbstractAn original ZnO nanowire (NW) architecture has been developed, entirely based on a soft chemistry approach, and thoroughly assessed through optical measurements and electromagnetic simulations. This architecture relies on the photoimprinting of a sol–gel ZnO‐based photosensitive seed layer combined with the subsequent localized hydrothermal growth of ZnO NWs. The optimization of the elaboration protocol has been shown to lead to uniform and reproducible linear and periodic gratings of ZnO NWs with a width/pitch of 2/4 µm. The NW gratings are compared with full‐covered samples (NWs coating) elaborated from a nonimprinted seed layer. A morphological study reveals that NW gratings present a peculiar hedgehog‐like profile. Standard and angle‐resolved photoluminescence studies demonstrate that the ZnO NWs visible emission is strongly modified by the presence of NW gratings and that its red part is directionally extracted and enhanced by a factor of up to 2. The electromagnetic simulations performed for both samples highlight the role of the gratings acting as coupled microcavities that boost the ZnO emission through light localization and diffractive mechanisms. It enables the extraction of the resonant photons at specific angles and wavelengths.
Selective C−H Bond Functionalization of Unprotected Indoles by Donor‐Acceptor Carbene Insertion
Authors: Diego Pizarro Juan , Morán‐González Lucía , González‐Fernández Iván , Maseras Feliu , Fructos Manuel R. , Pérez Pedro J. 
Published: July 2023

AbstractCopper catalysts containing alkoxydiaminophosphine (ADAP) ligand catalyze the selective C3−H functionalization of unprotected indoles upon carbene transfer from donor‐acceptor diazo compounds, the N−H bond remaining unaltered during the transformation. Mechanistic studies, including DFT calculations, allows proposing the existence of two competitive pathways, none of them occurring through the formation of cyclopropane intermediates, at variance with previously reported systems.
Gold‐Catalyzed Annulation of Ynamides with Aminocarbonyls as a Route to 2‐Aminoquinolines Diversely Substituted at the 4th‐Position
Authors: Shcherbakov Nikolay V. , Kotikova Polina F. , Chikunova Elena I. , Dar'in Dmitry V. , Kukushkin Vadim Yu. , Dubovtsev Alexey Yu. 
Published: July 2023

AbstractGold‐catalyzed interplay between ynamides and aminocarbonyls comprises a route to 2‐aminoquinolines. This modular annulation proceeds under relatively mild conditions (Ph3PAuCl/AgNTf2 5 mol %, DCE, 60–80 °C), and a number of functionalities were compatible (42 examples; 25–98% yields). In contrast to a group of other gold‐catalyzed methods employing the ynamide/amine combinations for the assembly of 2‐aminoquinolines, the developed approach utilizes a diversity of aminocarbonyl substrates and, in particular, allows a variation of the substituents in the 4th quinoline position. The synthetic potential of the obtained heterocyclic products was illustrated by post‐modifications of the quinoline backbone and the peripheral substituents.
Viral Nanoparticles‐Mediated Delivery of Therapeutic Cargo
Authors: Zanganeh Saba , Doroudian Mohammad , Nowzari Zohreh R. , Nasirmoghadas Pourya , Nahand Javid Sadri , Sepehrpour Shima , Moghoofei Mohsen 
Published: July 2023

AbstractThe rapid advancement of nanotechnology in recent years has opened new avenues of investigation for biomedical sciences. Viral nanoparticles (VNPs) are formulated from plant viruses, mammalian viruses, or bacteriophages. Based on their structure, viruses, and synthetic carriers have been utilized to design bio‐inspired nanocarriers, which serve as building blocks for innovative therapeutic applications. Scientists can chemically or genetically engineer VNPs to encompass various properties, such as enhancing their functionalization with therapeutic molecules and imaging reagents, enabling targeted delivery to specific ligands. The implementation of these novel nanocarrier platforms can revolutionize treatments for cancer, infectious diseases, and chronic illnesses. The primary goal of drug delivery systems is to localize cargo to the specific target site, increasing therapeutic benefits and minimizing off‐target effects. This review critically evaluates the major virus species used as nanocarriers, their applications in therapeutics, and their advantages and disadvantages.
The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice
Authors: Li Shuoshuo , Hu Wenyu , Gong Shenghui , Zhang Ping , Cheng Jinbo , Wang Shukun , Wang Yingyi , Shi Wenjun , Li Qianqian , Wang Fengchao , Yuan Zengqiang 
Published: July 2023

AbstractHigh altitude exposure leads to various cognitive impairments. The cerebral vasculature system plays an integral role in hypoxia‐induced cognitive defects by reducing oxygen and nutrition supply to the brain. RNA N6‐methyladenosine (m6A) is susceptible to modification and regulates gene expression in response to environmental changes, including hypoxia. However, the biological significance of m6A in endothelial cell performance under hypoxic conditions is unknown. Using m6A‐seq, RNA immunoprcipitation‐seq, and transcriptomic co‐analysis, the molecular mechanism of vascular system remodeling under acute hypoxia is investigated. A novel m6A reader protein, proline‐rich coiled‐coil 2B (PRRC2B), exists in endothelial cells. PRRC2B knockdown promoted hypoxia‐induced endothelial cell migration by regulating alternative splicing of the alpha 1 chain of collagen type XII in an m6A‐dependent manner and the decay of matrix metallopeptidase domain 14 and ADAM metallopeptidase domain 19 mRNA in an m6A‐independent manner. In addition, conditional knockout of PRRC2B in endothelial cells promotes hypoxia‐induced vascular remodeling and cerebral blood flow redistribution, thus alleviating hypoxia‐induced cognitive decline. Therefore, PRRC2B is integral in the hypoxia‐induced vascular remodeling process as a novel RNA‐binding protein. These findings provide a new potential therapeutic target for hypoxia‐induced cognitive decline.
Ultrastable Cu‐Based Dual‐Channel Heterowire for the Switchable Electro‐/Photocatalytic Reduction of CO2
Authors: Li Bo , Liu Xiao , Lei Bin , Luo Haiqiang , Liu Xize , Liu Hengzhi , Gu Qinfen , Ma Jian‐Gong , Cheng Peng 
Published: July 2023

AbstractCatalytic conversion of CO2 into high value‐added chemicals using renewable energy is an attractive strategy for the management of CO2. However, achieving both efficiency and product selectivity remains a great challenge. Herein, a brand‐new family of 1D dual‐channel heterowires, Cu NWs@MOFs are constructed by coating metal–organic frameworks (MOFs) on Cu nanowires (Cu NWs) for electro‐/photocatalytic CO2 reductions, where Cu NWs act as an electron channel to directionally transmit electrons, and the MOF cover acts as a molecule/photon channel to control the products and/or undertake photoelectric conversion. Through changing the type of MOF cover, the 1D heterowire is switched between electrocatalyst and photocatalyst for the reduction of CO2 with excellent selectivity, adjustable products, and the highest stability among the Cu‐based CO2RR catalysts, which leads to heterometallic MOF covered 1D composite, and especially the first 1D/1D‐type Mott–Schottky heterojunction. Considering the diversity of MOF materials, the ultrastable heterowires offer a highly promising and feasible solution for CO2 reduction.
Printed Electronics in Radiofrequency Energy Harvesters and Wireless Power Transfer Rectennas for IoT Applications
Authors: Skarżyński Kacper , Słoma Marcin 
Published: July 2023

AbstractThe Internet of Things is currently one of the fastest‐growing branches in electronics. The development of energy storage systems and the miniaturization of dedicated printed circuit boards significantly influence that growth. However, the need for batteries and traditional printed circuit boards still limits devices' minimum size, weight, and cost, narrowing the application area. Energy harvesters and wireless power transfer systems fabricated with printed electronics can significantly reduce such devices' weight, size, and cost. Printed electronics technology provides scalable tools for many electronics applications, shortening the validation time and enabling new low‐cost or disposable solutions on lightweight and flexible substrates embedded inside 3D printed structures and directly on device housings. Energy harvesting and wireless power transfer systems in electronic devices can provide enough power to minimize battery capacity and size or even eliminate the need for batteries in low‐power applications. This review presents an adaptation of printed electronics technology in the fabrication of radio frequency energy harvesters and wireless power transfer rectennas for IoT applications. Last, perspectives for development towards greater integration with microsystems, transient electronics with ecofriendly materials, adaptation for next‐generation telecommunication systems, and 3D structural electronics solutions are briefly discussed.
Recent Progress in the Catalytic Synthesis of Pyrrolo[1,2‐α]quinoxaline
Authors: Liu Quan , Wang Wenquan , Liu Meng 
Published: July 2023

AbstractPyrrolo[1,2‐α]quinoxaline and its derivatives have excellent biological activity and photoelectric properties, and are widely used in the fields of pharmaceutical preparations and organic electroluminescence. This review starts from catalysts and summarizes the single metal catalysis of palladium, rhodium, iron, molybdenum, and copper, as well as the synergistic catalysis of iron molybdenum bimetallic and metal‐free catalytic systems for the synthesis of pyrrolo[1,2‐α]quinoxaline. The pyrrolo[1,2‐α]quinoxaline catalytic mechanism in the different catalytic systems was detailly introduced and analysed. By analysing the advantages and disadvantages of existing catalyst systems, the prospects of new catalysts and methods for synthesis of pyrrolo[1,2‐α]quinoxaline are presented.
Chronic rhinosinusitis with nasal polyps (CRSwNP) treated with omalizumab, dupilumab, or mepolizumab: A systematic review of the current knowledge towards an attempt to compare agents’ efficacy
Authors: Papacharalampous Georgios X. , Constantinidis Jannis , Fotiadis George , Zhang Nan , Bachert Claus , Katotomichelakis Michael 
Published: July 2023

AbstractBackgroundThe heterogeneity of existing studies, along with the fact that there are no published head‐to‐head trials, are the main reasons for the lack of guidelines regarding the selection of the proper biologic in treatment of chronic rhinosinusitis (CRS) with nasal polyps. The aim of this study is to summarize the current knowledge regarding the efficacy of omalizumab, dupilumab, and mepolizumab in CRS treatment. We also attempt to proceed to an indirect comparison of the agents and try to answer the tricky question: which agent to select and why?MethodsAn extensive search in English literature was conducted in PubMed/Medline, Embase, Google Scholar, and Cochrane Database/Library. Eligibility criteria included papers with full text published in English, adult population studies, clearly described intervention protocol, and documented primary and secondary outcomes.ResultsThe studies included numbered 37. All agents provided significant improvement in polyp size, sinuses opacification, severity of symptoms, need for surgery and systemic corticosteroids use. Analysis of available systematic reviews, meta‐analyses and indirect treatment comparison studies showed that dupilumab appeared to be the most beneficial agent, in terms of primary and secondary outcomes. However, these results are of relatively low level of evidence due to several methodological limitations.ConclusionsAlthough the present analysis showed a moderate supremacy of dupilumab, there is still no evidence‐based answer to the question “which biologic agent is the most effective in CRS treatment?” Improved statistical methodology, head‐to‐head trials, and real‐life studies could lead to more robust conclusions, establishing the real role of the specific biologic agents.
Do Early Relapses Predict the Risk of Long‐Term Relapsing Disease in an Adult and Paediatric Cohort with MOGAD?
Authors: Chen Bo , Gomez‐Figueroa Enrique , Redenbaugh Vyanka , Francis Anna , Satukijchai Chanjira , Wu Yan , Messina Silvia , Sa Mario , Woodhall Mark , Paul Friedemann , Robertson Neil P. , Lim Ming , Wassmer Evangeline , Kneen Rachel , Huda Saif , Blain Camilla , Halfpenny Christopher , Hemingway Cheryl , O'Sullivan Eoin , Hobart Jeremy , Fisniku Leonora K. , Martin Roswell J. , Dobson Ruth , Cooper Sarah A. , Williams Victoria , Waters Patrick , Chen John J. , Pittock Sean J. , Ramdas Sithara , Leite Maria Isabel , Flanagan Eoin P. , Geraldes Ruth , Palace Jacqueline 
Published: July 2023

ObjectiveMyelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) can be monophasic or relapsing, with early relapse being a feature. However, the relevance of early relapse on longer‐term relapse risk is unknown. Here, we investigate whether early relapses increase longer‐term relapse risk in patients with MOGAD.MethodsA retrospective analysis of 289 adult‐ and pediatric‐onset patients with MOGAD followed for at least 2 years in 6 specialized referral centers. “Early relapses” were defined as attacks within the first 12 months from onset, with “very early relapses” defined within 30 to 90 days from onset and “delayed early relapses” defined within 90 to 365 days. “Long‐term relapses” were defined as relapses beyond 12 months. Cox regression modeling and Kaplan–Meier survival analysis were used to estimate the long‐term relapse risk and rate.ResultsSixty‐seven patients (23.2%) had early relapses with a median number of 1 event. Univariate analysis revealed an elevated risk for long‐term relapses if any “early relapses” were present (hazard ratio [HR] = 2.11, p < 0.001), whether occurring during the first 3 months (HR = 2.70, p < 0.001) or the remaining 9 months (HR = 1.88, p = 0.001), with similar results yielded in the multivariate analysis. In children with onset below aged 12 years, only delayed early relapses were associated with an increased risk of long‐term relapses (HR = 2.64, p = 0.026).InterpretationThe presence of very early relapses and delayed early relapses within 12 months of onset in patients with MOGAD increases the risk of long‐term relapsing disease, whereas a relapse within 90 days appears not to indicate a chronic inflammatory process in young pediatric‐onset disease. ANN NEUROL 2023;94:508–517
Activated Wake Systems in Narcolepsy Type 1
Authors: Shan Ling , Linssen Suzan , Harteman Zoe , den Dekker Fleur , Shuker Lamis , Balesar Rawien , Breesuwsma Nicole , Anink Jasper , Zhou Jingru , Lammers Gert Jan , Swaab Dick F. , Fronczek Rolf 
Published: July 2023

ObjectiveNarcolepsy type 1 (NT1) is assumed to be caused solely by a lack of hypocretin (orexin) neurotransmission. Recently, however, we found an 88% reduction in corticotropin‐releasing hormone (CRH)‐positive neurons in the paraventricular nucleus (PVN). We assessed the remaining CRH neurons in NT1 to determine whether they co‐express vasopressin (AVP) to reflect upregulation. We also systematically assessed other wake‐systems, since current NT1 treatments target histamine, dopamine, and norepinephrine pathways.MethodsIn postmortem tissue of people with NT1 and matched controls, we immunohistochemically stained and quantified neuronal populations expressing: CRH and AVP in the PVN, and CRH in the Barrington nucleus; the key neuronal histamine‐synthesizing enzyme, histidine decarboxylase (HDC) in the hypothalamic tuberomammillary nucleus (TMN); the rate‐limited‐synthesizing enzyme, tyrosine hydroxylase (TH), for dopamine in the mid‐brain and for norepinephrine in the locus coeruleus (LC).ResultsIn NT1, there was: a 234% increase in the percentage of CRH cells co‐expressing AVP, while there was an unchanged integrated optical density of CRH staining in the Barrington nucleus; a 36% increased number of histamine neurons expressing HDC, while the number of typical human TMN neuronal profiles was unchanged; a tendency toward an increased density of TH‐positive neurons in the substantia nigra compacta; while the density of TH‐positive LC neurons was unchanged.InterpretationOur findings suggest an upregulation of activity by histamine neurons and remaining CRH neurons in NT1. This may explain earlier reports of normal basal plasma cortisol levels but lower levels after dexamethasone suppression. Alternatively, CRH neurons co‐expressing AVP neurons are less vulnerable. ANN NEUROL 2023;94:762–771
Synthese von Cobalt‐Zinn‐ und ‐Blei‐Tetrylidinen – Reaktivitätsuntersuchungen der Dreifachbindung
Authors: Auer Maximilian , Zwettler Kathrin , Eichele Klaus , Schubert Hartmut , Sindlinger Christian P. , Wesemann Lars 
Published: July 2023

AbstractDie Tetrylidine [TbbSn≡Co(PMe3)3] (1 a) und [TbbPb≡Co(PMe3)3] (2) (Tbb=2,6‐[CH(SiMe3)2]2‐4‐(t‐Bu)C6H2) wurden über eine Substitutionsreaktion zwischen [Na(OEt2)][Co(PMe3)4] und [Li(thf)2][TbbEBr2] (E=Sn, Pb) erstmals dargestellt. Alternativ wurde das Stannylidin [Ar*Sn≡Co(PMe3)3] (1 b) durch eine Wasserstoffatom‐Abstraktion am paramagnetischen Hydridkomplex [Ar*SnH=Co(PMe3)3] (4) in einer Reaktion mit AIBN (AIBN=Azobis(iso‐butyronitril)) synthetisiert. Das Stannylidin 1 a addiert zwei Äquivalente Wasser, wobei das Dihydroxid [TbbSn(OH)2CoH2(PMe3)3] (5) erhalten wird. Bei der Reaktion des Stannylidins 1 a mit CO2 wurde ein Produkt einer Redoxreaktion [TbbSn(CO3)Co(CO)(PMe3)3] (6) isoliert. Die Protonierung des Tetrylidins erfolgt am Cobaltatom und ergibt das Metallastannavinyl‐Kation [TbbSn=CoH(PMe3)3][BArF4] (7 a) [ArF=C6H3‐3,5‐(CF3)2]. Die analogen Germanium‐ und Zinnkationen [Ar*E=CoH(PMe3)3][BArF4] (E=Ge 9, Sn 7 b) (Ar*=C6H3(2,6‐Trip)2, Trip=2,4,6‐C6H2iPr3) wurden durch Oxidation der paramagnetischen Komplexe [Ar*EH=Co(PMe3)3] (E=Ge 3, Sn 4) ebenfalls erhalten, welche durch Substitution eines PMe3‐Liganden am [Co(PMe3)4]‐Komplex durch eine Hydridoylen‐Einheit (Ar*EH) synthetisiert werden können.
Reaktionsinduzierte Metall‐Metalloxid‐Wechselwirkungen in Pd‐In2O3/ZrO2 Katalysatoren fördern die selektive und stabile CO2‐Hydrierung zu Methanol
Authors: Pinheiro Araújo Thaylan , Morales‐Vidal Jordi , Giannakakis Georgios , Mondelli Cecilia , Eliasson Henrik , Erni Rolf , Stewart Joseph A. , Mitchell Sharon , López Núria , Pérez‐Ramírez Javier 
Published: July 2023

AbstractTernäre Pd‐In2O3/ZrO2 Katalysatoren beweisen technologisches Potenzial für die CO2‐basierte Methanolsynthese, wobei die Entwicklung skalierbarer Systeme und das Verständnis komplexer dynamischer Wechselwirkungen zwischen der aktiven Phase, des Promotors und des Trägers der Schlüssel zur Erreichung einer hohen Produktivität sind. Hier zeigen wir, dass durch einfache Imprägnierung hergestellte Pd‐In2O3/ZrO2 Katalysatoren unter CO2‐Hydrierbedingungen eine stabile und selektive Nanoarchitektur bilden, unabhängig von der Reihenfolge der Zugabe von Pd‐ und In‐Komponenten auf den Zirkonoxidträger. Detaillierte operando Charakterisierung und Simulationen deuten auf eine schnelle Umstrukturierung, dessen Treiber die Energie der Metall‐Metalloxid‐Wechselwirkung ist. Die Nähe von InOx‐Schichten auf den entstehenden InPdx‐Partikeln verhindern Leistungsverluste durch Pd‐Sinterung. Weiterhin unterstreichen die Ergebnisse die entscheidende Rolle der reaktionsinduzierten Umstrukturierung in komplexem CO2‐Hydrierkatalysatoren und bieten Einblicke in die optimale Integration von Säure‐Base‐ und Redoxfunktionen für die technische Umsetzung.
An In‐Situ Cyanidation Strategy To Access Tetracyanodiacenaphthoanthracene Diimides with High Electron Mobilities Exceeding 10 cm2 V−1 s−1
Authors: Wu Zeng , Liu Wentao , Yang Xin , Li Wenhao , Zhao Lingli , Chi Kai , Xiao Xuetao , Yan Yongkun , Zeng Weixuan , Liu Yunqi , Chen Huajie , Zhao Yan 
Published: July 2023

AbstractA family of novel highly π‐extended tetracyano‐substituted acene diimides, named as tetracyanodiacenaphthoanthracene diimides (TCDADIs), have been synthesized using a facile four‐fold Knoevenagel condensation strategy. Unlike conventional cyano substitution reactions, our approach enables access to a large π‐conjugated backbone with the in‐situ formation of four cyano substitutents at room temperature while avoiding extra cyano‐functionalization reactions. TCDADIs decorated with different N‐alkyl substituents present good solubility, near‐coplanar backbones, good crystallinity, and low‐lying lowest unoccupied molecular orbital energies of −4.33 eV, all of which contribute to desirable electron‐transport performance when applied in organic field‐effect transistors (OFET). The highest electron mobility of an OFET based on a 2‐hexyldecyl‐substituted TCDADI single crystal reaches 12.6 cm2 V−1 s−1, which is not only among the highest values for the reported n‐type organic semiconductor materials (OSMs) but also exceeds that of most n‐type OSMs decorated with imide units.
Enantioselective C3‐Allylation of Pyridines via Tandem Borane and Palladium Catalysis
Authors: Tian Jun‐Jie , Li Rui‐Rui , Tian Gui‐Xiu , Wang Xiao‐Chen 
Published: July 2023

AbstractHerein, we report a one‐pot method for enantioselective C−H allylation of pyridines at C3 via tandem borane and palladium catalysis. This method involves borane‐catalyzed pyridine hydroboration to generate dihydropyridines, then palladium‐catalyzed enantioselective allylation of the dihydropyridines with allylic esters, and finally air oxidation of the allylated dihydropyridines to afford the products. This method enables the introduction of an allylic group at C3 with excellent regio‐ and enantioselectivities.
Centrifugally spun PVP/ZnO composite fibers with different surfactants and their use as antibacterial agents
Authors: Sanchez Jo Ann , Ibrahim Amin , Materon Luis , Parsons Jason G. , Alcoutlabi Mataz 
Published: July 2023

AbstractPolyvinylpyrrolidone (PVP) fibers embedded with Zinc Oxide nanoparticles (ZnO NPs) were prepared by the centrifugal spinning of aqueous PVP solutions and ZnO NPs. The ZnO NPs were synthesized and coated with either cetyltrimethylammonium bromide or hexadecyltrimethylammonium bromide. The structure and morphology of the nanocomposite fibers were studied using scanning electron microscopy, X‐ray diffraction, energy‐dispersive X‐ray spectroscopy, Fourier transformed infrared spectroscopy and Thermogravimetric analysis. The effect of surfactant coating on the antibacterial activity of ZnO NPs and PVP/ZnO nanocomposite fibers against Escherichia coli (E. coli) and Bacillus megaterium (B. megaterium) bacteria was systematically investigated. The present study indicated that coating the ZnO NPs with surfactants resulted in large and uniform inhibition of bacterial growth.