bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Potential Prognostic Value of Clock-related LncRNA with Immune Implications in Non-small Cell Lung Cancer
Authors: Shen Yizhong , Zhuang Jinman , Li Ronghui , Li Xiuting , Huang Lindan , Zhang Hanyu , Hu Zhijian , Kang Mingqiang , He Fei 
Published: January 2023

Abstract
Objective
Our aim is to construct a prognostic model of clock-related lncRNAs for patients with non-small cell lung cancer (NSCLC) and evaluate its relationship with tumor immune microenvironment.
Methods
The data of 944 NSCLC cases were screened and obtained from the TCGA database. Circadian rhythm-related Gene Set (consisting of 70 clock-related genes) was identified using the GSEA website. Clock-related lncRNAs were obtained by co-expression analysis. The abundance of immune cell infiltrates in NSCLC patients was calculated using CIBERSORT. Clock-related lncRNAs risk scores were calculated via the Least Absolute shrinkage and Selection Operator (LASSO) penalized Cox regression analysis. Then we divided the 944 NSCLC cases into training set (473 cases) and validation set (471 cases) based on the median risk score. The independence risk factors for clinical pathological parameters and risk score were analyzed using the univariate and multivariate Cox regression analysis. We also explored the relationship between risk score and immune cell infiltration in NSCLC cases.
Results
A total of 12 clock-related lncRNAs were selected from the training set to calculate the risk score. Patients in the high-risk group had poor prognosis than patients in the low-risk group, which were both validated in the training set and validation set (P < 0.001, P < 0.05, respectively). The area under the curve (AUC) of risk score was 0.763 and 0.624, respectively. Multivariate Cox analysis showed that T stage, N stage, age, and clock-related lncRNAs risk score were independent risk factors for prognosis of patients with NSCLC. B Cell naive and Mast cells resting showed high invasion abundance in the low-risk groups (P < 0.01), while Macrophages M0, Macrophages M1 and Neutrophils cells showed high infiltration abundance in the high-risk groups (P < 0.01).
Conclusions
In conclusion, the risk score of 12 clock-related lncRNAs was identified as a prognostic biomarker for patients with NSCLC, and was significantly associated with the regulation of immune cell subtypes.
Learning through connections: Clinical participation and interpersonal relationships in longitudinal integrated clerkships and traditional block rotations in Taiwan
Authors: Chan Po-Kai , Wang Yung-Chih , Huang Shih-Chung , Chang Yaw-Wen 
Published: January 2023

Abstract
Background: Longitudinal integrated clerkships (LICs) and traditional block rotations (TBRs) employ different designs that provide various learning experiences for students. In this study, we explored students’ clinical participation and interpersonal interactions in LICs and TBRs at 2 metropolitan hospitals in Taiwan.
Methods: In April 2018, we enrolled 15 LIC and 29 TBR students. We conducted a cross-sectional survey which required the students to outline a typical daily schedule during their internal medicine rotations and draw an ecomap of the clinical team members. With the patient in the center as a reference, the size of each circle in an ecomap indicated the importance of the member; the distances and number of connecting lines between two circles represented the relationship and frequency of interaction, respectively, between the corresponding members. We analyzed the results and compared the responses of the LIC and TBR students.
Results: The LIC students spent more time on direct patient care and in the outpatient clinic/operation room, whereas the TBR students participated more in educational activities and in observation behind their seniors. In the ecomap analysis, the LIC students had a closer relationship with attending physicians and had better interactions with patients and preceptors than did the TBR students. Conversely, the TBR students felt closer to and interacted more frequently with interns and residents.
Conclusions: The LIC students had more opportunities to care for patients directly and engaged in interactions with patients and attending physicians more frequently than did the TBR students.
Trial registration: Ethical approval for the study was obtained from the Institutional Review Board of Tri-Service General Hospital (TSGHIRB 2–106–05-018)
Electron Blocking Layer Architecture to enhance the hole injection in the active region for 215 nm Ultra-violet Light Emitting Diode (UVC-LED)
Authors: Hussain Hadba , Alrubaian Renad Ali , Almogbel Abdullah , Alharbi Abdullah 
Published: January 2023

Abstract
This work engineered the p-Electron Blocking Layer (p-EBL) of the AlGaN-based deep ultraviolet (UVC) light-emitting diode (LED) to achieve a high Radiative Recombination Rate (RRR). Carrier concentration can be efficiently injected into the active region by inserting an undoped thin AlGaN layer between the doped p-AlGaN layer as a superlattice. Compared with the UVC-LED with the bulk p-AlGaN EBL, the superlattice LED improves the optical power, holes and electrons concentration, and RRR.
Exosomal miR-216a-5p targeting TLR-4 alleviates liver ischemia-reperfusion injury by regulating M2 macrophage polarization and neutrophil inflammation
Authors: Liu Long , Huang Yuxi , Wang Qi , Zhao Xiaohong , Feng Yu-yi , Fang Zheping , Qiao Yingli , Li Shao-Wei 
Published: January 2023

Abstract
Macrophages and neutrophil play a key role in the initiation and recovery of liver ischemia reperfusion injury (IRI) through transitions in the phenotype and induces inflammation, However, the mechanisms governing these damages have yet to be fully elucidated. Exosomes have emerged as an important mediator of cellular crosstalk in various physiological and pathological processes. This study explored the role of exosomal miRNA in macrophage polarization and liver IRI. Through high-throughput sequencing of small RNAs in exosomes, we identified the negative regulator miR-216a-5p in liver IRI. Mechanistically, miR-216a-5p skewed M2 macrophage polarization and inhibited neutrophil infiltration by targeting TLR4. In conclusion, we demonstrated that exosome-derived miR-216a-5p favors an anti-inflammatory environment by promoting the M2 polarization of macrophages and inhibiting the neutrophil inflammatory response by targeting the TLR4/NF-κB and PI3K/AKT signaling pathways, revealing the endogenous protective mechanism in liver IRI.
Inter-arm blood pressure difference in post-stroke patients with hemiparesis
Authors: PENG Hai-ping , TAO Liang , TANG Min , Su Hai 
Published: January 2023

Abstract
The aim of this study was to Tinvestigate that inter-arm blood pressure (BP) difference (IAD) in post-stroke patients with hemiparesis. This study enrolled 420 post-stroke patients with hemiparesis. Simultaneous bilateral arm BP was measured with two automatic BP devices, and the systolic BP difference ≥ 10 mm Hg was recorded as sIAD. The arm with higher systolic BP (SBP) was assigned as the reference arm. Our results showed that the prevalence of sIAD was 18.1% in the total group. The paretic arms had similar mean SBP levels (133.6 ± 18.4 vs 133.8 ± 18.4 mm Hg, NS) and DBP (77.8 ± 11.5 vs 77.2 ± 10.9 mm Hg, NS) as compared with the unaffected arms. The detection rate of hypertension on the SBP values of the reference arm was higher than that on the unaffected arm (41.8% vs 36.3). In is convoluted that the prevalence of sIAD ≥ 10 mmH was 18.1% and that for dIAD ≥ 10 mmH was 9% in the post-stroke patients with hemiparesis, thus, bilateral arm BP measurement is encouraged for evaluating IAD and decreasing the miss diagnosis of hypertension.
Long-Term Individual Trip Pattern Prediction of Bus Passengers Using Smart Card Data: A Bayesian Method Based on Feature Selection
Authors: Li Dawei , Dai Qi , Zhang Tong , Shi Xiaomeng 
Published: January 2023

Abstract
Travel demands of bus passengers tend to be diversified and personalized, for targeted demand management and dynamic system operations, it is important to predict individual trip patterns. Smart card records can be combined with other data to infer the future trip patterns of passengers. This provides an effective method to study individual travel behavior in the field of public transportation. This paper proposes a methodology for predicting the travel patterns of individual bus passengers, including the prediction of trip start time and trip start station. Based on a passenger segmentation model, passengers with more frequent and regular bus trips are extracted first. Then combined with the information provided by date attributes and weather data, the most relevant influencing feature of the individual traveler's trip on the day are selected as the prediction feature. Afterwards, we use bayesian models to predict the individual traveler's future trip start time and station. The proposed methodology is tested using the long-term observation of smart card data from 1000 users of bus system in Kunshan, Jiangsu Province over one year. Our prediction achieves median accuracy levels over 65% and 70% for trip start time t and trip start station s. The proposed model can be easily applied to transport demand management. It can also be used for the design and optimization of customized public transport systems. In this way not only will bus passengers be better served, but the overall level of traffic control and management in the city will also be effectively improved.
Directed regulation mechanism on chlorine substitution of PCDD/Fs isomers based on quantum chemical computation
Authors: Hou Meiling , Zhang WenJie , Hu Jun , Wang Xinlei , Wang Jinxing , Cen Wanglai 
Published: January 2023

Abstract
Chlorine substitution has been considered as one of the key steps of polychlorinated dibenzodioxin/furan (PCDD/Fs) generation. The introduction of oxygen carriers (OCs), especially in chemical looping combustion (CLC), provides the platform of directed regulation for the chlorine substitution process. 12378-PCDD, which is the product of a one-step chlorine substitution for toxic 2378-PCDD, has been selected as the calculation case, and the regulation mechanisms on the inter-isomeric conversion of 12378-PCDD were identified by calculating the energy barrier and action angle. It was found that the chlorine substitution of 12378-PCDD, particularly in 4# position, 9# position and 6# position, emerged a tendency to increase the difficulty in turn, which conforms to the principle of distal preference. Besides, the influence from CaO adsorption on the crystalline surface of the iron-based oxygen carrier(OC) has been analyzed and it was verified that CaO adsorption can significantly increase the energy barrier for the chlorine substitution of 12378-PCDD. Meanwhile, the adsorption of CaO can not only change the action angle between the 12378-PCDD molecule and the lattice surface, but also can modulate the energy barrier order of chlorine substitution among PCDD isomers. In addition, the loading component modulation was carried out to further confirm the feasibility of modulating the chloride substitution pathway, which proved the influence degree of loading component. And accordingly, the stretching analysis of the inactive component provides a theoretical basis for the subsequent study of the directional regulation of the PCDDs isomer generation pathway. Finally, the chlorine substitution rules and directed regulation mechanisms of PCDD/Fs isomers were obtained, which provides a modification direction for the structural components of OCs.
Prader-Willi syndrome complicated with nephrotic syndrome and acute kidney injury: a case report
Authors: Wang Tingli , Bi Siwei , Mi Xuhua 
Published: January 2023

AbstractBackground:Prader-Willi syndrome (PWS) is a multisystem disorder caused by aberrant genomics which silences genes in the 15q11-q13 region. It is characterized by multiple cognitive, behavioral, and endocrine abnormalities.Case presentation:We present a case of a 28-year-old male patient diagnosed with PWS with diabetes mellitus, nephrotic syndrome (proteinuria > 3.5 g/24 h) and acute kidney injury who eventually entered end-stage renal disease and started dialysis. Through genetic diagnosis, we found that the patient had heterozygous deficiency in the chr15 deletion segment. The patient’s mother was heterozygous and the father was wild-type, suggesting that the 4.86 Mb deletion in the 15q11.2-q13.1 segment of the patient was a paternal chromosomal deletion.Conclusion:PWS has various clinical manifestations and a poor prognosis. Early diagnosis, long-term follow-up, and in-time treatment could improve the quality of life and prognosis of PWS patients.
Label-free incoherent super-resolution optical microscopy
Authors: Jayakumar Nikhil , Dullo Firehun , Tinguely Jean-Claude , Sagini Krizia , Llorente Alicia , Ahluwalia Balpreet Singh 
Published: January 2023

Abstract

The photo-kinetics of fluorescent molecules has enabled the circumvention of far-field optical diffraction-limit. Despite its enormous potential, the necessity to label the sample may adversely influence the delicate biology under investigation. Thus, continued development efforts are needed to surpass the far-field label-free diffraction barrier. The coherence of the detected light in label-free mode hinders the application of existing super-resolution methods based on incoherent fluorescence imaging. In this article, we present the physics and propose a methodology to circumvent this challenge by exploiting the photoluminescence of silicon nitride waveguides for near-field illumination of unlabeled samples. The technique is abbreviated EPSLON, Evanescently decaying Photoluminescence Scattering enables Label-free Optical Nanoscopy. We demonstrate that such an illumination has properties that mimics the photo-kinetics of nano-sized fluorescent molecules. This allows to develop a label-free incoherent system that is linear in intensity, and stable with time thereby permitting the application of techniques like structured illumination microscopy (SIM) and intensity-fluctuation based optical nanoscopy (IFON) in label-free mode to circumvent the diffraction limit. We experimentally demonstrate label-free super-resolution imaging of nanobeads (polystyrene and gold), extra-cellular vesicles and human placenta tissue. We believe EPSLON is a step forward within the nascent field of label-free super-resolution microscopy that holds the key to investigate delicate biological systems in its natural state without the need for exogenous labels.
Is probiotic (Streptococcus Salivarius K12) useful in Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis syndrome?
Authors: Mobini Niloofar Khorsand , Ahanchian Hamid , Malek Abdolreza , Khadem-Rezaiyan Majid , Pourbadakhshan Nafiseh 
Published: January 2023

Abstract
Background: The most common periodic fever syndrome in children is Periodic Fever, Aphthous stomatitis, Pharyngitis, and Adenitis (PFAPA). This study aimed to investigate the effectiveness of the probiotic Streptococcus Salivarius K12 in patients with PFAPA.
Materials and Methods: This randomized clinical trial included PFAPA patients divided into intervention and control groups. The intervention group, along with the conventional treatments, received Lactogum containing Probiotic Streptococcus Salivarius K12 for four months. The control group, however, received conventional treatments, including acetaminophen and non-steroidal anti-inflammatory drugs (prednisolone), along with a placebo.
Results: This study investigated 40 PFAPA patients. The mean ages of the patients in the control and intervention groups were 6.94±2.21 and 5.71±2.59 years, respectively. In the first month, the mean number of days suffering from fever was fewer in the intervention group, compared to the control group. Moreover, the mean number of pharyngitis days in the first and second months was fewer in the intervention group than other group.There was also a significant difference between the intervention and control groups in terms of corticosteroid use in the fourth month after the onset of probiotic treatment (P≤0.05).
Conclusion: Our results suggest that, the use of probiotics (Streptococcus Salivarius K12) could be effective in reducing the symptoms of PFAPA syndrome, as well as the consumption of corticosteroids
Name of the registry: The Use of Streptococcus salivarius K12 in treatment of Periodic fever with aphthous stomatitis, pharyngitis, and adenitis (PFAPA) Syndrome
Date of registration: 31/08/2021
Trial registration: IRCT20210911052436N1).
URL: https://www.irct.ir/trial/58774
Diagnostic accuracy of customized foetal growth charts in the detection of adverse perinatal outcome of term small for gestational age foetuses
Authors: Tipiani-Rodríguez Oswaldo , Bocanegra-Becerra Yuliana , Huarag-Chavarri Christopher , Figueroa-Morales Kristtel , Ponciano-Biaggi Miguel 
Published: January 2023

Abstract
Purpose
To determine the diagnostic accuracy of Peruvian customized foetal growth charts in the detection of adverse perinatal outcome (APO) in term small for gestational age (SGA) fetuses.
Methods
This was an observational, cross-sectional, case‒control study, with 555 pregnant women treated at a hospital in Lima, Peru, whose foetal weights were evaluated by Peruvian charts and growth standards of the World Health Organization (WHO), Fetal Medicine Foundation (FMF), Hadlock and INTERGROWTH-21st Project (IG21).
Results
The prevalence of SGA using the Peruvian charts was 10.5%, and the OR was 9.9, with an effect size > 0.8. The PPV of the Peruvian char (52.5%) was higher than those of the Hadlock and FMF standards. The NPV (90%) was higher than that of the FMF standard. The LR + was 5.8, with strong evidence to confirm the diagnosis, but with an LR- = 0.6. The performance of the Peruvian charts in predicting APO was poor (AUC = 0.688), but they performed well in predicting an Apgar score < 7 at 5 minutes (AUC = 0.852), outperforming the WHO and FMF standards.
Conclusion
Peruvian customized charts more accurately estimated the prevalence of SGA and had a large effect size for the association between SGA and APO. The diagnostic metrics support the use of the Peruvian charts as a diagnostic and prognostic test in which the probability of APO is reduced when the diagnosis of SGA is excluded, and also as a test with a good ability to predict an Apgar score < 7 at 5 minutes.
EBV negative lymphoepithelioma-like carcinoma of the thyroid gland: a rare entity and incidental presentation
Authors: Bendari Ahmed 
Published: January 2023

Abstract
Background: Lymphoepithelioma-like carcinoma (LELC) is a rare entity among thyroid tumors. Primary LELC of the thyroid was previously named as intrathyroidal epithelial thymoma and carcinoma showing thymus-like differentiation (CASTLE) and the association with EBV has been inconsistently detected. This paper presents fine-needle aspiration cytology (FNAC) findings along with histologic features of LELC in a middle-aged female patient with incidental metastatic disease.
Case presentation:
A previously healthy 29-Year-old female who had an incidental palpable nodule in the right thyroid lobe on routine annual checkup. Thyroid U/S showed a 1.5 cm hypoechoic solid nodule with ill-defined margins. FNAC revealed papillary architecture and a few psammoma bodies on the background of dense lymphocytic infiltration. Thyroseq genomic sequencing revealed gene expression alterations with no gene mutation. The patient went for total thyroidectomy and right lymph node level 4 resection. The histologic slides of the nodule revealed solid arborizing bands of oval to spindled cells, associated with lymphoplasmacytic infiltrate and scattered psammoma bodies on the background of lymphocytic thyroiditis. There were no classic patterns of papillary or any aggressive features. Immunohistochemically, the tumor was positive for TTF1, PAX-8, and P40. In situ hybridization for EBV-encoded RNA was negative in the tumor cells. The patient has no tumor recurrence on 6-month follow up.
Conclusion: Because LELC is very rare in the thyroid gland, careful clinical examination along with IHC stainings specific for thyroid follicular cells can help in proving its thyroid origin. Additionally, we hope to raise the awareness for this peculiar variant for accurate clinicopathological diagnosis.
DeepSHARQ: Hybrid Error Coding using Deep Learning
Authors: Pereira Pablo Gil , Vogelgesang Kai , Miodek Moritz , Schmidt Andreas , Herfet Thorsten 
Published: January 2023

Abstract
Purpose: Cyber-Physical Systems operate under changing environments and on resource-constrained devices. Communication in these environments must use hybrid error coding, as pure pro- or reactiveschemes cannot always fulfill application demands or have suboptimal performance. However, findingoptimal coding configurations that fulfill application constraints—e.g., tolerate loss and delay—underchanging channel conditions is a computationally challenging task.
Methods: Recently, the systems community has started addressing these sorts of problems usinghybrid decomposed solutions, i.e., algorithmic approaches for well-understood formalized parts ofthe problem and learning-based approaches for parts that must be estimated (either for reasons ofuncertainty or computational intractability). For DeepSHARQ, we revisit our own recent work andlimit the learning problem to block length prediction, the major contributor to inference time (andits variation) when searching for hybrid error coding configurations. The remaining parameters arefound algorithmically, and hence we make individual contributions with respect to finding close-to-optimal coding configurations in both of these areas—combining them into a hybrid solution.
Results: DeepSHARQ applies block length regularization in order to reduce the neural networksin comparison to purely learning-based solutions. The hybrid solution is nearly optimal concerningthe channel efficiency of coding configurations it generates, as it is trained so deviations from theoptimum are upper-bound by a configurable percentage. Additionally, DeepSHARQ is capable ofreacting to channel changes in real-time, thereby enabling Cyber-Physical Systems even on resource-constrained platforms.
Conclusion: Tightly integrating algorithmic and learning-based approaches allows DeepSHARQ toreact to channel changes faster and with a more predictable time than solutions that rely only oneither of the two approaches.