bluuebunny/crossref_metadata_2025_split huggingface dataset:
(244) PROSTATE CANCER PATIENTS’ EXPERIENCE OF SEXUAL DYSFUNCTION AND SUPPORT ACCORDING TO TREATMENT PATHWAY
Authors: William Kinnaird , Prof. Michael Kirby , Dr. Patricia Schartau , Prof. Valerie Jenkins , Dr. Stephen Allen , Prof. Heather Payne 
Published: July 2023

Abstract

Objectives
Sexual dysfunction (SD) is a common side effect of almost all prostate cancer (PCa) treatments. This study examined how men’s experience of sexual side effects and accessing information and support varied by treatment pathway.

Methods
An anonymous online survey was distributed via email, social media and peer-support groups in collaboration with the charity Prostate Cancer UK. Results were analysed by treatment pathway: Radical Prostatectomy (RP), Radiotherapy (RT), Androgen Deprivation Therapy (ADT) ± second line therapy (Androgen Receptor Targeted Agent, Chemotherapy, Radioisotope), and No Treatment (Active Surveillance, Watchful Waiting, Awaiting Treatment). Chi-square testing was used for categorical variable analysis.

Results
A total of 654 adult participants met the inclusion criteria and were included in the analysis. Sexual activity was ‘fairly/very important’ to the majority of men irrespective of treatment group. Sexual dysfunction was wide-ranging and common across almost all pathways, with men on combinations of treatment reporting problems most frequently [Fig 1]. Participants whose disease management involved RP were significantly more likely to have had discussions about SD with a healthcare professional (HCP) than those managed with RT and/or ADT alone (80.1% vs 43.3%, p&lt;.001). Those discussions were also significantly more likely to have led to a referral for specialist sexual support (49.1% vs 26.6%, p&lt;.001). However, there was dissatisfaction across groups, with a only minority of participants reporting they were ‘told everything I needed to know’ about SD and rating their care as ‘adequate’ [Fig 1].

Conclusions
This study investigated a wide range of sexual problems across PCa treatment pathways. Findings suggest physical and psychological sexual side effects are common and distressing in all treatment groups. Men place high importance on sexual activity, but only a minority are satisfied with the information and support they receive. Unmet needs are greatest among men whose disease is managed in the oncological setting with RT and ADT.

Conflicts of Interest
Astellas Pharma Resaerch Grant UK-72-RG-41.
(251) BIOCHEMICAL PREDICTORS OF STRUCTURAL HYPOTHALAMUS-PITUITARY ABNORMALITIES DETECTED BY MAGNETIC RESONANCE IMAGING IN MEN WITH SECONDARY HYPOGONADISM
Authors: Dr. Sarah Cipriani , Dr. Tommaso Todisco , Dr. Nicola Ghiandai , Prof. Linda Vignozzi , Dr. Giovanni Corona , Prof. Mario Maggi , Prof. Giulia Rastrelli 
Published: July 2023

Abstract

Objectives
Organic conditions underlying secondary hypogonadism (SH) may be ascertained by magnetic resonance imaging (MRI) of the hypothalamic-pituitary region that could not be systematically proposed to each patient. Based upon limited evidence, the Endocrine Society (ES) guidelines suggest total testosterone (T) &lt; 5.2 nmol/L to identify patients eligible for MRI. The study aims to identify markers and their best threshold value predicting pathological MRI findings in men with SH.

Methods
A consecutive series of 609 men seeking medical care for sexual dysfunction and with SH (total T &lt; 10.5 nmol/L and LH ≤ 9.4 U/L) was retrospectively evaluated. An independent cohort of 50 men with SH was used as validation sample. 126 men in the exploratory sample and the whole validation sample underwent MRI.

Results
In the exploratory sample, patients with pathological MRI findings (n = 46) had significantly lower total T, luteinizing hormone (LH), follicle stimulating hormone (FSH) and prostate specific antigen (PSA) than men with normal MRI (n = 80). Receiver Operating Characteristics analysis showed that total T, LH, FSH and PSA are accurate in identifying men with pathologic MRI (accuracy: 0.62-0.68, all p &lt; 0.05). The Youden index was used to detect the value with the best performance, corresponding to total T 6.1 nmol/L, LH 1.9 U/L, FSH 4.2 U/L and PSA 0.58 ng/mL. In the validation cohort, only total T ≤ 6.1 nmol/L and LH ≤ 1.9 U/L were confirmed as significant predictors of pathologic MRI.

Conclusions
In men with SH, total T ≤ 6.1 nmol/L or LH ≤ 1.9 U/L should arise the suspect of hypothalamus/pituitary structural abnormalities, deserving MRI evaluation.

Conflicts of Interest
none
(269) COMPARISON BETWEEN TWO DIFFERENT TECHNIQUES FOR THE TREATMENT OF PENILE PARAFFINOMA: AESTHETIC AND FUNCTIONAL OUTCOMES
Authors: Dr. Angelo di Giovanni , Dr. Alessandro Giordano , Dr. Carlo D'Alterio , Dr. Claudio Marino , Dr. Luigi Napolitano , Dr. Lorenzo Cirigliano , Dr. Claudia Mirone , Prof. Alessandro Palmieri , Dr. Massimiliano Creta , Dr. Roberto La Rocca , Dr. Marco Capece 
Published: July 2023

Abstract

Objectives
To evaluate the differences in terms of aesthetic and functional outcomes of two different surgical techniques in the treatment of penile paraffinoma.

Methods
From September 2018 to July 2022 we selected 9 patients with penile paraffinoma. Patients were then subdivided into 2 groups. In group 1 (G1), four patients underwent a paraffinoma excision and split thickness skin graft reconstruction in one stage. Inclusion criteria for G1: patients suffering penile paraffinoma with small scrotum size or scrotal involvement.
In group 2 (G2), five patients underwent 2-stages surgical technique: on the first stage we performed excision of paraffinoma and penile scrotalization. three-six month later during the second stage, a scrotoplasty was performed.
All participants were invited to complete two different questionnaires, the international index of erectile function (IIEF-5) and a 6-items questionnaire on the satisfaction of genital aesthetics. The questionnaires were delivered by email. Datas were collected up to one year after surgery and a statistical analysis using SPSS V 26.0 3.4.

Results
No statistical significant differences in terms of IIEF-5 were observed between G1 (20,5 IQR 19-21,25) and G2 (20 IQR 19-22) (p-value 0,49). Otherwise, a statistically significant difference (p-value &lt;0,05) was recorded between G1-G2 in the 6-items questionnaires regarding the satisfaction of genital aesthetics (9,00 IQR 6,75-10,5 vs 13 IQR 4-11 respectively).

Conclusions
In our experience, in patients suffering from penile paraffinoma with no scrotal involvement, a dual stage technique with scrotoplasty is resulting in better aesthetic outcomes rather than a split thickness skin graft. However, a single stage technique, using a split thickness skin graft, also provides good clinical outcome, including acceptable cosmetic results, patient satisfaction, and sexual function. Therefore, in our opinion, both techniques should be considered to enable surgeons to choose from among them based on the patient's preoperative characteristics.

Conflicts of Interest
The Authors declair no conflict of interest.
(112) PELVIC FLOOR MUSCLE TRAINING IMPROVES SEXUAL FUNCTION AND DIMINISHES SEXUAL DISTRESS IN WOMEN WITH MULTIPLE SCLEROSIS
Authors: Athanasios Zachariou , Vagia Sapouna , Ioannis Giannakis , Aris Kaltsas , Prof. Fotios Dimitriadis , Prof. Athanasios Papatsoris , Prof. Panagiota Tsounapi , Prof. Charalampos Mamoulakis , Prof. Atsushi Takenaka , Prof. Nikolaos Sofikitis 
Published: July 2023

Abstract

Objectives
Pelvic floor muscle training (PFMT) contributes to better sexual function, as their strength and ability to properly contract improves vaginal receptivity and responsiveness, orgasm and sexual pleasure. Multiple sclerosis (MS) is the most common chronic nervous system disorder leading to sexual dysfunction, with a prevalence of 40-70%. The primary outcome of this study was to evaluate the effect of PFMT on improving sexual function and sexual distress in women suffering from MS.

Methods
In this randomized controlled trial, 30 women suffering from MS were randomly included in an intervention Group A (12 weeks PFMT), and 30 women were randomly included in a control Group B (observation group; negative control group). All women were assessed with the Female Sexual Function Index (FSFI) and Female Sexual Distress Scale-Revised (FSDS-R) at the study's beginning and end. Statistical analysis was performed using a Chi-square test.

Results
Differences in baseline sexual function and distress variables were not significant between groups A and B (P&gt;0.05). At the end of the twelve-week period, there was a statistically significant improvement in nearly all domains of FSFI and FSDS-R in Group A compared with Group B. Women with PFMT (Group A) displayed higher statistically significant results (p&lt;0.05) in desire (Group A: 3.54+0.18 vs Group B: 2.94+0.15), arousal (4.33+0.36 vs 3.92+0.47), orgasm (4.91+0.52 vs 3.93+0.29), satisfaction (5.01+0.56 vs 3.96+0.29), lubrication (4.81+0.36 vs 3.82+0.34), total FSFI score (27.14+1.17 vs 22.71+0.91) and FSDS-R score (7.35+4.51 vs 9.23+4.62). There was no statistically significant difference in the pain domain. Seven women in Group A and none of the women in Group B reported that their sexual difficulties were resolved at the end of the trial period.

Conclusions
Pelvic floor muscle training can enhance sexual function and diminish sexual distress in women with MS.

Conflicts of Interest
Conflict of interest: none
(170) ACUTE STRESS DISORDER DURING LABOR IS A PREDICTOR OF POST-PARTUM DYSPAREUNIA
Authors: Dr. Anna Padoa , Dr. Roni Tomashev , Dr. Inbal Brenner , Ayelet Golan , May S Igawa , Dr. Ido Lurie , Dr. Yael Reicher , Anat Talmon , Prof. Karni Ginzburg 
Published: July 2023

Abstract

Objectives
Few studies have addressed the relationship between peri-partum emotional parameters and post-partum dyspareunia. The aim of this study was to assess the prediction of dyspareunia 3 months postpartum by obstetrical outcomes, perceptions of childbirth experience and emotional adjustment immediately following childbirth. [if !supportLineBreakNewLine] [endif]

Methods
Four-hundred and forty women were recruited within 48 hours postpartum (T1) in the maternity ward from April 2018 to August 2020. Self-report questionnaires were administered at T1 and again 3 months postpartum (T2), addressing demographic and reproductive background, pre-partum dyspareunia, pain during labor, perceived threat, sense of control and acute stress disorder (ASD) during labor. Obstetrical information was retrieved from clinical files. [if !supportLineBreakNewLine] [endif]

Results
Two-hundred and sixty-three women filled the dyspareunia questionnaire at both T1 and T2. Of those, 237 (91.2%) reported having sex since childbirth (T2); 47 women (17.9%) were classified into the pre-partum dyspareunia, and 60 women (22.8%) as post-partum dyspareunia. Of the dyspareunia group at T2, 40% (n = 24) were also classified into the dyspareunia group at T1. Dyspareunia severity at T1 and T2 were moderately correlated (r = .39, p &lt; .001). Women with post-partum dyspareunia (group 1) and women without post-partum dyspareunia (group 2) were compared for demographic, obstetrical and emotional parameters. Demographic data were similar between groups. Dyspareunia was not related to pain during childbirth. Women in the post-partum dyspareunia group reported more birth-related ASD symptoms, than comparisons. ASD symptoms at T1 predicted dyspareunia severity at T2 (B = .81, SE = .26, p= .002) after controlling for participants’ age, birthweight, pain during childbirth, and dyspareunia severity at T1.

Conclusions
ASD immediately after labor is a predictor of postpartum dyspareunia. Peripartum caregivers should be cognizant of this association, addressing ASD symptoms in the immediate postpartum period and assessing for sexual wellness in women after childbirth.

Conflicts of Interest
Anna Padoa: Pierre Fabre Group- speaker honorarium ESSIC- board member
(65) PSYCHOSEXUAL DEVELOPMENT, SEXUAL FUNCTIONING AND SEXUAL SATISFACTION IN LONG TERM CHILDHOOD CANCER SURVIVORS: DCCSS-LATER 2 SEXUALITY SUBSTUDY
Authors: Cristina Priboi , Dr. Marloes van Gorp , Dr. Heleen Maurice-Stam , Prof. Gisela Michel , Prof. Leontien Kremer , Prof. Wim Tissing , Dr. Jacqueline Loonen , Dr. Helena van der Pal , Dr. Andrica de Vries , Prof. Marry van den Heuvel-Eibrink , Dr. Cécile Ronckers , Dr. Dorine Bresters , Marloes Louwerens , Dr. Sebastian Neggers , Margriet van der Heiden-van der Loo , Prof. Eline van Dulmen-den Broeder , Prof. Martha Grootenhuis 
Published: July 2023

Abstract

Objectives
Childhood cancer may negatively impact childhood cancer survivors’ (CCS) sexuality. However, this is an understudied area of research. Our study aimed to describe the psychosexual development, sexual functioning and sexual satisfaction of CCS, compare these outcomes to the Dutch population and identify determinants for CCS’ sexuality.

Methods
From the Dutch Childhood Cancer Survivor Study LATER cohort (diagnosed 1963-2001), 1912 CCS (18-71 years, 50.8% male) completed questions on sexuality, psychosocial development, body perception, mental and physical health. Sexuality of CCS age 18-24 was compared to the general Dutch population using binominal tests and t-tests. Multivariable regression analysis was used to identify determinants.

Results
Compared to general population peers, CCS age 18-24 showed significantly less experience with masturbation (p=.045), French kissing (p=.007), petting under clothes (p=.001), oral (p=.008) and anal sex (p=.016). No significant differences were found for problems with sexual functioning and sexual satisfaction neither among female CCS nor male CCS when compared to peers age 18-24. One third of all CCS reported hindered sexuality due to childhood cancer, with body dissatisfaction most often mentioned reason (44.8%). The regression analysis identified older attained age, body perception, lower mental health and surviving central nervous system tumors as determinants for reduced sexuality.

Conclusions
CSS reported less psychosexual development, but similar sexual functioning and sexual satisfaction compared to the general population. We identified determinants for sexuality, which could be integrated in specific communication training for health professionals and development of clinical interventions for CSS with reduced sexuality.

Conflicts of Interest
No conflict of intrest.
(343) PERCEPTIONS OF SEXUAL BOREDOM IN A COMMUNITY SAMPLE
Authors: Leonor de Oliveira , Prof. Joana Carvalho , Prof. Pedro Nobre 
Published: July 2023

Abstract

Objectives
Although sexual boredom is a common concern, there seems to be a gap in the overall research and, specifically, concerning this construct’s meaning for different people. This work aimed to explore the definitions of sexual boredom in a large community sample of Portuguese individuals.

Methods
Data were collected between September 2019 and February 2020 and constitute a secondary use of data from a larger quantitative online study. After completing the survey, participants were directed to a non-mandatory, open-ended item asking: “What is sexual boredom for you?”. The present study refers to the answers given to this item. From the 927 total respondents to the survey, 653 answered to the open-ended item. Participants ages varied between 18 to 75 years old (M = 33.14; SD = 9.01) and had multiple genders, sexual orientations, and relationship types. Following this, was conducted a thematic analysis with NVivo 12 PRO software of the participants’ written responses using Braun and Clarke’s foundational guidelines.

Results
Three main themes were identified: definitions of sexual boredom, predisposing and maintenance factors of sexual boredom, and managing of sexual boredom. Sexual monotony, sexual desire, and hedonic value stand out as defining features of sexual boredom. Participants referred to individual (cognitive, emotional, and physical factors), interpersonal (partner and relationship factors), and practice related facets, and suggest different paths in and out of sexual boredom.

Conclusions
Sexual boredom is a multidimensional construct that is not captured by most research. Based on this thematic analysis, sexual boredom can be defined as the perception of monotonous or unpleasurable sexual activity or of lack of sexual interest, related to individual, relationship, or practice aspects of sexual relationships, and which may lead to exploring sexual novelty or to the progressive waning of sexual desire. Findings have clinically implications and indicate the need of a multidimensional measure of sexual boredom.

Conflicts of Interest
No conflicts of interest to declare.
(67) PORNOGRAPHY AND SEXUAL SATISFACTION IN RELATIONSHIPS
Authors: Eliška Lexová , Prof. Petr Weiss 
Published: July 2023

Abstract

Objectives
The associations between pornography consumption and sexuality are still debated in recent research. Should we consider pornography harmful or rather beneficial for relationships? The research aimed to point out the associations between the consumption of pornography in relationships and the frequency of sexual activities, sexual desire, and sexual satisfaction.

Methods
Having used an online questionnaire, we compared individuals from relationships in which pornography is consumed together, separately, by only one of the partners, or not at all. The sample for the current study included 1 742 participants. Overall, the average relationship length in the sample was 81.2 months. For data analysis, ANOVA and ANCOVA were used, followed by the Kruskal-Wallis test and the Chi-square test of independence. Based on previous research, we included various factors and covariates in the elementary association between patterns of pornography consumption and partner sexual activity that could interfere with the results of the main analysis. This includes, for example, age, gender, marital status, education, religion, etc.

Results
One-way ANOVA indicated a significant main effect of the way pornography is consumed in relationships on sexual desire, F (3,1738) = 11.57, p = &lt;.001, η2 =.020, and on sexual satisfaction, F (3,1738) = 65.18, p &lt;.001, η2 =.101. Individuals who consume pornography together with partner and non-consumers had the highest frequency of sexual activity per month and were the most sexually satisfied compared to relationships where pornography is consumed separately or by only one of the partners. Also, partners consuming pornography together still had the highest sexual desire.

Conclusions
Overall, these findings suggest that it is preferable to consume pornography in a relationship together, or rather not at all. The significance of the results is discussed also in relation of various intervening variables entering into the relationship between patterns of pornography use and partner sexual activity.

Conflicts of Interest
The authors have no competing interests to declare that are relevant to the content of this presentation.
(144) STEP-BY-STEP PROCEDURE: IMPLANTATION OF A MALLEABLE PENILE PROSTHESIS
Authors: Priv-Doz. Daniar K Osmonov , Ahmed M Ragheb , Dr. Jan Novák 
Published: July 2023

Abstract

Objectives
In this video, we present an implantation of a malleable penile prosthesis in a 73-year old male who previously underwent radical prostatectomy for prostate cancer with subsequent radiotherapy. Additionally, he underwent implantation of an inflatable penile prosthesis AMS 700 and an arteficial urinary sphincter AMS 800. Since recently his inflatable penile prosthesis is defective and the patient prefers implantation of a malleable penile prosthesis. The aim of the video is to stress out the main differences between implantantion of an inflatable and a malleable penile prosthesis.

Methods
0

Results
0

Conclusions
0

Conflicts of Interest
Daniar K. Osmonov – Coloplast Porges.
(35) THE KIEL KNOTS TECHNIQUE FOR THE TREATMENT OF CONGENITAL AND ACQUIRED PENILE CURVATURE
Authors: Osmonov Prof Daniar , Ahmed Ragheb 
Published: July 2023

Abstract

Objectives
We propose a surgical technique for the correction of both congenital and acquired penile curvatures. Our technique is based on modifying and combining the 16-dot and the Essed-Schroeder plication techniques by burying the knots in shallow troughs of the incised tunica albuginea. We entitle this modification as the “Kiel Knots”. In this video, we demonstrate step-by-step the Kiel Knots technique for the correction of a case of dorsal acquired curvature with good erectile function via the subcoronal approach.

Methods
A circumcising incision is made and the penis is degloved. Buck’s fascia is then incised exposing the tunica albuginea opposite to the curvature. Eight dots 5mm apart are marked bilaterally on the tunica albuginea with the point of maximum curvature in the center and a 5 mm superficial transverse incision is made along each mark without cutting into the corpus cavernosum. Instead of plicating with one suture for 4 dots, our modification entails utilizing a separate suture for every two dots with the knot being buried in the shallow trough we created by the scalpel.

Results
Our average operative time is an hour. An average loss of penile length of 0.5-1cm has been reported in 30% of our patients. All our patients preserved their erectile function. 90% of our patients remained without recurrence of curvature after 2 years of surgery. None of our patients reported problems with their suture knots.

Conclusions
Our technique achieves penile straightening with minimal loss of length and no erectile dysfunction. We believe that the “Kiel Knots” technique combines the best of Lue’s 16 dot technique together with the Essed-Schroeder plication technique while avoiding the downsides of both approaches.

Conflicts of Interest
The authors have no conflict of interest.
(189) INVESTIGATING THE RISK FACTORS OF PENILE ARTERIAL INSUFFICIENCY AND VENO-OCCLUSIVE DYSFUNCTION IN PATIENTS WITH ERECTILE DYSFUNCTION
Authors: Dr. Mohamad Habous , Dr. Ahmed Khattak , Gordon Muir 
Published: July 2023

Abstract

Objectives
penile arterial insufficiency (PAI) is a known cause of erectile dysfunction (ED). It was reported that a more generalized peripheral atherosclerotic process is associated with a severer PAI, and this in turn was correlated well with decreased blood supply in more important arteries like the coronary and carotid arteries. We investigated the risk factors for PAI.

Methods
Patients who attended our urology clinic complaining of ED for more than 6 months, were prospectively enrolled in this study in one year period. Patient consent was taken and ethical committee approval. Complete medical history and thorough general and local examination including body mass index (BMI), Peyronie’s disease (PD) and penile size measurements (length and girth) were done for all of them. Laboratory tests included testosterone, lipid profile, and glycated haemoglobin (HbA1c). Penile duplex ultrasound study (PDU) was done for all patients after intra-cavernosal injection (ICI) with Alprostadil. peak systolic velocity (PSV) and end diastolic velocity (EDV) were measured after 15 minutes.

Results
Patients who attended our clinic complaining of ED for more than 6 months, were prospectively enrolled in this study in one year period. Patient consent was taken and ethical committee approval. Complete medical history and thorough general and local examination including body mass index (BMI), Peyronie’s disease (PD) and penile size measurements (length and girth) were done for all of them. Laboratory tests included testosterone, lipid profile, and glycated haemoglobin (HbA1c). Penile duplex ultrasound study (PDU) was done for all patients after intra-cavernosal injection (ICI) with Alprostadil. peak systolic velocity (PSV) and end diastolic velocity (EDV) were measured after 15 minutes.

Conclusions
Aging, tobacco consumption, DM and hypertension seem to have a negative impact on penile hemodynamics, which was statistically significant. In our patients, there was no statistically significant effect on penile hemodynamics in patients with increased BMI, low testosterone, PD or according to penile size

Conflicts of Interest
None