bluuebunny/crossref_metadata_2025_split huggingface dataset:
Properties and effects of a drug-loaded haemostatic sponge
Authors: Wang Lusha , Meng Jia , Jia Xujing , Wang Wei , Wang Jiayan , Huang Jibin , Wu Di , Zhang Xiuqiang , Xu Ming 
Published: March 2023

Abstract
Some cases of chronic rhinosinusitis (CRS) require surgical treatment and postoperative nasal packing, but bleeding and adhesion are common complications after nasal surgery. Biodegradable drug-loaded implants hold great therapeutic options for the treatment of CRS, but little data are available regarding the properties and effects of a novel drug-loaded haemostatic sponge (DLHS) in the nasal cavity and sinus. In this study, in vitro and in vivo experiments were used to test the physicochemical properties and investigate the biocompatibility and effectiveness of DLHS. The results showed that DLHSs present outstanding porosity and liquid absorption capacity, which might enhance their haemostatic ability, and they possess sustained-release ability for drugs. Further clinical trials confirmed their clinical efficacy and safety, and there was no evidence of adrenal cortical suppression. This study demonstrates the safety and efficacy of a novel biodegradable drug-loaded sponge with the possibility of being used in CRS patients, and this sponge may reduce inflammation and minimize adhesions via controlled local drug delivery without measurable systemic exposure.
Typical Diagnostic Reference Levels of Common Indications for Computed Tomography Scans Among Adult Patients in Uganda: a Cross-sectional Study
Authors: Nalwoga Kevina , Nankya Ethel , Erem Geoffrey , Mayanja John Mark Kasumba , Kiragga Festo , Mubuuke Aloysius G. , Kisembo Harriet 
Published: March 2023

Abstract
Background
Medical exposure to ionizing radiation has increased due to an increase in the number of computerized tomography (CT) scan examinations performed. The International Commission on Radiological Protection (ICRP) recommends indication-based diagnostic reference levels (IB-DRLs) as an effective tool that aids in optimizing CT scan radiation doses. In many low-income settings, there is a lack of IB-DRLs to support optimization of radiation doses.
Objective
To establish typical DRLs for common CT scan indications among adult patients in Kampala, Uganda.
Methodology:
A cross sectional study design was employed involving 337 participants enrolled from three hospitals using systematic sampling. The participants were adults who had been referred for a CT scan. The typical DRL of each indication was determined as the median value of the pooled distribution of CTDIvol (mGy) data and the median value of the pooled distribution of total DLP (tDLP)(mGy.cm) data from three hospitals. Comparison was made to anatomical, and indication based DRLs from other studies.
Results
54.3% of the participants were male. The following were typical DRLs for: acute stroke (30.17mGy and 653mGy.cm); head trauma (32.04mGy and 878mGy.cm); interstitial lung diseases/ high resolution chest CT scan (4.66mGy and 161mGy.cm); pulmonary embolism (5.03mGy and 273mGy.cm); abdominopelvic lesion (6.93mGy and 838mGy.cm) and urinary calculi (7.61mGy and 975mGy.cm). Indication based total Dose Length Product (tDLP) DRLs was lower than tDLP DRLs of a whole anatomical region by 36.4% on average. Most of the developed typical IB-DLP DRLs were lower or comparable to values from studies in Ghana and Egypt in all indications besides urinary calculi while they were higher than values in a French study in all indications besides acute stroke and head trauma.
Conclusion
Typical IB-DRLs is a good clinical practice tool for optimization of CT doses and therefore recommended for use to manage CT radiation dose. The developed IB-DRLs varied from international values due to differences in selection of CT scan parameters and standardization of CT imaging protocols may narrow the variation. This study can serve as baseline for establishment of national indication-based CT DRLs in Uganda.

*As a note, Kevina Nalwoga and John Mark Kasumba Mayanja are co-first authors.*
Identification of the role of pyroptosis -related genes in chronic rhinosinusitis based on WGCNA
Authors: Wan Yarui , Wang Yanfei , Xu Sheng , Du Hui , Liu Zhiqi 
Published: March 2023

Abstract
Background: Chronic rhinosinusitis (CRS) is a complex chronic inflammatory disease of the nose, paranasal sinus, and upper respiratory tract. Its treatment methods mainly include antibiotic treatment and surgical treatment. However, the molecular mechanism of its inflammation is still unclear. Pyroptosis is a programmed cell death. As an important natural immune response, pyroptosis plays an essential role in fighting infection.
Methods: In this paper, a weighted co-expression network (WGCNA) was used to screen gene modules significantly related to CRS. Then it intersects with the genes related to scorching death (PRGs). We evaluated the immune landscape of CRS by the expression of intersecting genes. In addition, in the enrichment analysis of intersection genes and PPI network analysis, we verified the pathways closely related to CRS and hub genes. Finally, the interaction network between the hub gene, miRNA, and TF was constructed.
Results: Hub genes (CASP3, IL18, NAIP, NLRC4, and TP53) found in this paper are directly or indirectly related to CRS, and these genes were proved to be of diagnostic significance to CRS by ROC curve. In the infiltration abundance of CRS and its control group, the infiltration abundance of Plasma cells, T cells follicular helper, Macrophages M2, Dendritic cells activated, and Neutrophils cells in the two groups were significantly different. We also constructed the interaction network between the hub genes and miRNAs and the interaction network between hub genes and TFs. Most of these miRNAs and TFs were also related to CRS.
Conclusions: Five hub genes were identified and verified by focusing on the role of apoptosis-related genes in CRS. And the immune landscape of the hub genes in CRS and its interaction with miRNA and TF were determined, respectively.
Study on the therapeutic effect of coral calcium hydrogenated, a material that slowly releases hydrogen, on allergic contact dermatitis
Authors: Luan Jing , Wang Yankang , Yu Song , Fu Xinyao , Xu Hao , Yan Bin , Gou Xingchun , Xu Lixian , Wang Xuzhen 
Published: March 2023

Abstract
Background
Hydrogen has been proven to play a protective role in vivo by its biological effects such as anti-oxidant, anti-inflammatory. Allergic contact dermatitis (ACD) is a common inflammatory skin disease characterized by itching, skin inflammation, and allergic responses. ACD is caused by T cell-mediated delayed type hypersensitivity.
Results
The aim of this study is to investigate the ameliorative effect of Coral calcium hydrogenated (CCH) which releases hydrogen slowly in the body and has more advantages than the direct use of hydrogen. 2,4-Dinitrochlorobenzene (DNCB) was applied for ACD induction. CCH was applied by intragastric administration. Dermatitis score and number of scratches were significantly diminished in CCH-treated groups. Especially, CCH showed inhibitory effects on skin lesion and hyperplasia. Additionally, splenic coefficient and plasma IgE were significantly inhibited by CCH.
Conclusions
Those findings suggested CCH has a remarkable effect on DNCB-induced ACD in mice.
Biota Interactions for Ecological Assessment of a Deteriorated Coastal Lake following a Brief Period of Restoration
Authors: Mitwally Hanan , Rashidy Hoda El , Montagna Paul 
Published: March 2023

Abstract

The coastal lake, Maruit, was one of the most productive coastal ecosystems in Egypt until the 1960s. It experienced long-term deterioration due to continuous discharge of pollutants from Alexandria city into its basins. The Egyptian government started a restoration program in 2010 to divert pollution sources away from the lake. Samples were collected in November 2012 to assess the biological condition of Lake Maruit using parasitism and predation as biological linkages between pelagic and benthic communities. A preliminary survey of ectoparasites infesting tilapia fish was carried out during this study. Ectoparasites that were retained from 300 sampled tilapia fish were identified. Two groups of platyhelminth ectoparasites, Monogenea,Cichlidogyrus sp.,and the parasitic-copepod,Ergasilus lizae,were detected. Ectoparasite Platyhelminthes infected the fishOreochromis niloticus and O. aureus, whereas the crustacean parasitizedCoptodon zillii.The parasitic prevalence was 15% and 3% forCichlidogyrus sp., andErgasilus lizae, respectively. Benthic biotas were similar among basins, which could indicate successful restoration. The lack of response of fish abundance to benthic biotic components indicates few direct trophic links. Phytoplankton and benthic microalgae were not the main fish diet. It was found that Halacaridae and fish data clustered, suggesting either Halacaridae are simply responding like fish or that fish are preying on them because they have a relatively large size. Unexpectedly, linear connections between the populations of biota and the parasite-infected fish were found, suggesting that parasites may control the behavior of their hosts. Organic matter concentration was the main driver of the lake ecosystem biota. While the low parasitism rate and lack of eutrophication is evidence of recovery, the low biota abundance, lack of fish and faunal diversity, and limited linkage among food web components indicate the restoration was incomplete or Lake Maruit was still suffering from degradation in 2012.
Whisker stimulation alleviate ASD behavior of BTBR mice by regulating Piezo2 expression in DRG and neuron function in S1 and mPFC
Authors: Zhai Jinhe , Hao Haiying , Xu Zihan , Li Xiaoxue , Xia Wei , Zhang Xinyi , Cao Xuan , Wang Xinxin , Li Dongxin , Wang Jia , Wu Lijie , Fan Lili 
Published: March 2023

Abstract
Background: Individuals with autism spectrum disorder (ASD) commonly experience sensory abnormalities, including tactile sensation, in addition to social and repetitive restrictive behavior. This study aimed to evaluate the tactile response characteristics of children with ASD and its correlation with core phenotypes, as well as investigate the role of Piezo2 mechanically sensitive ion channels in the tactile behavior of BTBR mice. Additionally, the study explored the effects of tactile intervention on the neural function of key sensory and social brain regions in mouse model.
Methods: A population questionnaire survey was conducted to compare the scores of the Short Sensory Profile (SSP) between children with ASD and typically developing children, and analyze the correlation between SSP and social response scales (SRS) and other clinical diagnostic tools in the ASD group. Behavioral tests such as Von Frey, three-chamber social test, open field, self-grooming, and Morris water maze were performed on BTBR and C57BL/6 mice to evaluate tactile and ASD characteristics. Expression of Piezo2 in the dorsal root ganglion (DRG), and the neural function in the mPFC/S1 brain region were detected in the whisker intervention group and the non-intervention group.
Results: Children with ASD showed significant tactile sensitivity compared to typically developing children, and increased tactile abnormality was associated with greater social abnormality. In animal experiments, BTBR mice with tactile overreaction exhibited over-expression of Piezo2 protein and mRNA in the DRG. Tactile intervention relieved tactile sensitivity and ASD symptoms, and decreased the over-expression of Piezo2. Additionally, there was a significant increase in dendritic spine density in S1 and mPFC brain regions, and a decrease in the level of c-fos.
Limitations: The causal relationship between ASD tactile sensitivity and social injury should be further clarified in future research. And clarify the neural mechanism of mild tactile stimulation affecting ASD symptoms.
Active Control Method for Phase and Chaos Synchronization within Two Coupled Food Chains Under Refugia and Allee Effect
Authors: Dwivedi Shubhangi , Kumari Nitu 
Published: March 2023

Abstract
This work investigates synchronization within a system of two coupled food chains. We assess the scenario if and how the chaotic dynamics of a food chain can be suppressed in the presence of other food chains and order can be restored within the system of coupled food chains. For this, we consider the extended version of Hasting Powell model (eHPM), in which two bio-controlling parameters, refugia, and Allee, are already present to suppress chaos. Through imperative mathematical properties and numerical simulations of the system, we first understand the impact of the interplay of refugia and Allee effects in defining the qualitative behaviour of the system. After analyzing the system's sensitive dependence on the initial condition, we use the master-slave scheme to attain synchronization within the system of two coupled food chains defined for three different frameworks. Following the active control method, Lyapunov stability theory is used to deduce the analytical expression for nonlinear active controllers for the synchronization of three different frameworks namely - (a) two identical eHPMs but with different qualitative behaviour (master eHPM possesses regular whereas slave eHPM possesses chaotic dynamics), (b) non-identical eHPM (master) and HP model (slave)~( eHPM possesses regular whereas HP model possesses chaotic dynamics), and (c) non-identical eHPM (master) and HP model (slave) with different initial conditions (both eHPM and HP model posses chaotic dynamics). Using techniques from active control theory, it is demonstrated that all three proposed systems can be phase and chaos synchronized. The time series plots of the error dynamics are used to validate that the slave system from all three frameworks adheres to the same control functions effectively for the synchronization process. Numerical simulation from the study can provide basis for assessing the potential significance of synchronization in a network of coupled food chains where Refugia and Allee effects are present.
Laplacian Nonlinear Logistic Stepwise and Gravitational Deep Neural Classification for Facial Expression Recognition
Authors: Kumari M.Binthu , Sivagami B. 
Published: March 2023

Abstract
Facial expression recognition is the paramount segment of non-verbal communication and one frequent procedures of human communication. Facial expression recognition, as one of the foremost evolution regulations of human-computer interaction, enhances the fluency and accuracy of relationship. Over the past few years, deep learning using feature selection of face image data based on machine and deep learning has become increasingly in demand, it has achieved progress, however due to different facial expression and attaining accuracy still remains major issue to be focused. Their accessibility shoots from their potentiality to select righteous features from face image data, via feature selection to achieve high performance at minimum time. In this work a method called, Laplacian Non-linear Logistic Regression and Gravitational Deep Learning (LNLR-GDL) for facial expression recognition is proposed. The proposed method is split into three sections, namely, preprocessing, feature selection and classification. In the first section, preprocessing is conducted with the face recognition dataset where noise reduced preprocessed face images are obtained by employing Unsharp Masking Laplacian Non-linear Filter model. Second with the preprocessed face images, computationally efficient relevant features are selected by means of Logistic Stepwise Regression-based feature selection model. Finally, Gravitational Deep Neural Classification model is applied to the selected features for robust recognition of facial expressions. The proposed LNLR-GDL method along with two state-of-the-art methods is implemented on corrective re-annotation of images for facial expression recognition. The databases comprise of consist of seven emotions viz., anger, contempt, disgust, fear, happiness, neutrality, sadness and surprise. The proposed method is compared with existing methods using three evaluation metrics namely, facial expression recognition accuracy, facial expression recognition time and PSNR. The obtained results demonstrate that the proposed LNLR-GDL method outperforms the state-of-the-art methods.
The effect of joint position sense therapy on chronic shoulder pain with central sensitisation
Authors: Chen Xin , Zha Lisi , Xuan Zhi , Zhang WeiMing 
Published: March 2023

Abstract
Objectives
Chronic shoulder pain is one of the common musculoskeletal problems involved with unreleased pain and functional dysfunction, and it can even evolve into central sensitisation. Some manual therapy aggravated pain and central sensitisation. Joint position sense therapy (JPST) is moderate joint proprioception training compared with vigorous exercises or aggressive hands-on therapy. This study will explore the expression of central sensitisation in chronic shoulder pain and the effect of JPST on shoulder functional dysfunction and pain.
Methods
Pressure pain threshold (PPT) was assessed together with four sites at the deltoid, upper trapezius, brachioradialis and tibialis anterior muscles among 30 chronic shoulder pain and 30 non-chronic pain patients. A total of 30 patients with chronic shoulder pain were randomly divided into the JPST group and a control group. The JPST group underwent additional shoulder joint position sense training. The efficiency outcomes were the Disabilities of the Arm, Shoulder, and Hand Questionnaire (DASH), Visual Analog Scale (VAS) and PPT evaluated at baseline and after the intervention.
Results
Significant differences were observed in PPT values at brachioradialis (P < 0.05), deltoid (P < 0.01) and trapezius (P < 0.001) among non-chronic and chronic groups, but not in tibialis anterior muscle (P > 0.05). Although both control and JPST intervention were effective in improving DASH, pain intensity and PPT values in the upper limb, outcomes in the JPST group showed significant differences from the control group.
Conclusions
A generalised hyperalgesia changes limited to the upper limb were noticed in chronic shoulder pain. Joint position sense therapy had a beneficial effect on pain control and functional dysfunction in chronic shoulder pain patients.
Comparison of calcaneal plate fixation and Philos plate fixation for the treatment of split fractures of the greater tuberosity of the humerus: a retrospective review
Authors: Wang Fei , Niu Xiaohui , Xia Haibo , Liang Wei , Lan Jun 
Published: March 2023

Abstract
Objective To compare the effect of two internal fixation methods of calcaneal plate fixation and Philos plate fixation for the treatment of split fractures of the greater tuberosity of the humerus.
Methods A retrospective analysis was carried out on the data of 37 patients with isolated split fractures of the greater tuberosity of the humerus treated in our hospital from September 2016 to April 2021. There were 24 males and 13 females, with an average of 46.7 (25-67) years old. All patients had fresh split fractures with displacement of >5mm and without other injuries (such as Bankart injury, SLAP injury and Hill-sachs injury). Enrolled patients were divided into two groups according to different internal fixation methods. Patients in group A were treated with calcaneal anatomical locking plate (n=16), and those in group B were given Proximal Humeral Internal Locking System (PHILOS) (n=21). Further comparison was conducted on the interval from injury to operation, length of incision, operation time, bleeding volume, postoperative Constant-Murley shoulder joint function score and complications between the two groups.
Results All the 37 cases had fracture healing during the follow-up period ranging from 10-23 months, with an average of 11.9 months. The average interval from injury to operation was 3.7 days (2-4 days) in group A and 4.1 days (3-6 days) in group B, with no significant difference. The average length of incision was 6.2cm (4.5cm-7.3cm) in group A and 9.1cm (8.2cm-10.7cm) in group B, with significant difference. The average operation time was 61 minutes (51-77 minutes) in group A and 65 minutes (57-79 minutes) in group B, with no significant difference. There was significant difference in the comparison of bleeding volume between group A and group B [47ml (35ml-63ml) vs. 103ml (79ml-125ml)]. During the 6-month follow-up, the average Constant-Murley score was 87.5 points (76-97 points) in group A and 80.3 points (71-91 points) in group B, with significant difference. In addition, shoulder impingement syndrome occurred in 2 cases in group B, but not in group A.
Conclusion Calcaneal anatomical locking plate can achieve satisfactory results in the treatment of adult fractures of the greater tuberosity of the humerus, with the advantages of less surgical trauma and less bleeding. Findings in our study can provide a new choice for the surgical treatment of isolated fractures of the greater tuberosity of the humerus.
KIF21B acts as an oncogene in hepatocellular carcinoma through the NF- κB/p65 signaling pathway
Authors: Chen Shi-Yong , Dong Xiao-Hua , Chang Jian-Hua , Dong Bao-Long , Yang Zi-Jiao , Wang Xin-Xin , Gao Peng , Cai Hui , Yang Xiao-Jun 
Published: March 2023

Abstract
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Its invasiveness and ability to metastasize contributes to an extremely high patient mortality. However, the molecular mechanisms that underlie the characteristics of HCC progression are not well understood. The kinesin superfamily 21 B (KIF21B) has been shown to be involved in hepatocellular carcinoma (HCC). Nevertheless, its role in HCC has not yet been thoroughly examined. Tumor Genome Atlas (TCGA) was used to analyze the difference of KIF21B expression between HCC and normal tissues and its relationship with clinicopathological features. For further validation, immunohistochemistry (IHC) was used to detect the expression of KIF21B in 116 cases of liver cancer. In vitro studies, we used loss-of-function assays to evaluate the effects of KIF21B and its direct target NF-κB(nuclear factor-κB) p65 subunit on cell growth, proliferation, apoptosis, migration, invasion, and epithelial-mesenchymal transition (EMT).Then the effect of KIF21B inhibition on tumor growth was studied in nude mice in vivo. We demonstrated that elevated KIF21B expression is associated with adverse clinicopathological features, such as tumor size, in HCC patients. In vitro experiments showed that silencing KIF21B could inhibit the proliferation, migration, invasion and EMT of HCC cells, and induce apoptosis, while overexpression of p65 could reverse these effects. In addition, silencing of KIF21B inhibited the growth of HCC in xenografts in nude mice. In this study, we identified and validated that KIF21B plays a carcinogenic role in HCC through NF-κB/p65 signaling pathway, providing a new insight into HCC pathogenesis and therapeutic possibilities.