bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apremilast in the Management of Generalized Granuloma Annulare: A Case Series
Authors: Nesvik Jazmine , Marshall Leslie , Cleaver David , Cleaver Jonathan , Cleaver Lloyd 
Published: July 2023

Background: Granuloma annulare is a difficult disease to treat and can lead to anxiety and frustration for both patients and providers. The pathogenesis of granuloma annulare is unknown, resulting in few thoroughly studied or consistently effective treatments.
Objective: 1) To discuss whether treatment with apremilast could lead to improvement or resolution of generalized granuloma annulare. 2) To explore the possible pathogenesis of granuloma annulare and the mechanism of apremilast in treating this disease.
Methods: A case series was used to study the clinical response of 6 patients with a history of recalcitrant generalized granuloma annulare taking apremilast 30mg twice daily.
Results: Two patients achieved complete clearance of their disease without recurrence while the remaining 4 patients achieved significant improvement in lesion number, induration, and erythema.
Limitations: This is a small case series and larger, controlled trials with long-term follow-up are needed. There is no objective method for evaluating the extent of disease improvement in granuloma annulare. Furthermore, our patients used concomitant topical and intralesional steroids while on apremilast.
Conclusion: This case series illustrates a novel therapy, apremilast, a phosphodiesterase-4 inhibitor, in the treatment of patients with generalized granuloma annulare and explores possible mechanisms behind the success of this treatment.
A Suspected Case of Imported Yaws in New York
Authors: Moloney Mairead , Teplitz Rebeca , How Brian , Sirota-Rozenberg Suzanne 
Published: July 2023

Introduction: Yaws is an endemic non-venereal treponematoses, which is caused by Treponema pallidum, subspecies pertenue and is spread from person-to-person through direct skin contact with an infected lesion. Yaws causes a chronic skin infection that is characterized by papillomas and ulcers and if left untreated can be disfiguring and debilitating. Cases typically occur in warm, humid, tropical climates and cases are commonly seen in children under 15 years old. However, due to migration, cases can be seen outside of its endemic region.
Case Description: We present a case of a 39-year-old African American male who presented with painless bilateral ulcers on his dorsal feet that began as blisters approximately 1-2 weeks prior to presentation at our clinic. Our patient had recent travel history to Jamaica and reported potential sources of trauma to his feet by walking barefoot on the beach and roofing in sandals prior to onset. These findings led to the clinical diagnosis of Yaws. A regimen of azithromycin and basic wound care led to significant improvement.
Discussion: Non-venereal endemic treponematoses, such as Yaws, are typically not seen outside of their endemic region. However, due to migration and the ease of travel non-venereal endemic treponematoses can be found elsewhere and it is important for healthcare workers to keep these diseases on their differential, especially in a patient with travel history. After making the diagnosis of Yaws, proper treatment and basic wound care can result in rapid significant improvement and prevent the progression of Yaws lesions to the subsequent stage.
Scalp, eyebrow, and eyelash hair regrowth with continued ritlecitinib treatment among patients with alopecia areata without target efficacy response at Week 24: post hoc analysis of the ALLEGRO phase 2b/3 study
Authors: Senna Maryanna , Forman Seth , Bordone Lindsey , De La Cueva Dobao Pablo , Wolk Robert , Zwillich Samuel , Zhang Fan , Mohamed Ahmed Haytham , Takiya Liza 
Published: July 2023

Background: This post hoc analysis of the ALLEGRO phase 2b/3 study (NCT03732807) assessed response to ritlecitinib, an oral JAK3/TEC family kinase inhibitor, between Weeks 28-48 among patients with alopecia areata (AA) who did not meet target efficacy response criteria at Week 24.
Methods: Patients aged ≥12 years with AA and ≥50% scalp hair loss received daily ritlecitinib 10 mg (included for dose ranging only), 30 or 50 mg (±4-week 200-mg daily loading dose), or placebo for 24 weeks. After Week 24, ritlecitinib groups continued their assigned doses and the placebo group switched to ritlecitinib 200/50 or 50 mg through Week 48. This analysis included patients receiving ritlecitinib 30 or 50 mg (±4-week 200-mg daily loading dose) who had not responded at Week 24, based on Severity of Alopecia Tool (SALT) score ≤20 (≤20% scalp without hair), SALT score ≤10, or eyebrow (EBA) or eyelash (ELA) assessment (normal or ≥2-grade improvement from baseline among patients with abnormal EBA or ELA score at baseline), and followed them through Week 48.
Results: Of the patients in the ritlecitinib groups who did not meet SALT ≤20 response at Week 24, 5-8% had response at Week 28, with rates increasing to 22-34% at Week 48. A similar trend was observed for SALT ≤10 (6-12% and 20-25%), EBA (8-14% and 20-33%), and ELA (4-15% and 17-30%) at Weeks 28 and 48, respectively, for patients not achieving the respective response at Week 24. Ritlecitinib was well tolerated through Week 48. Most common adverse events were upper respiratory tract infection, nasopharyngitis, and headache.
Conclusion: Patients with AA treated with ritlecitinib who don’t meet target efficacy response at Week 24 may achieve response at later time points with continued ritlecitinib treatment.
Evaluation of annexin A1 expression in lung, breast, colon, and prostatic adenocarcinomas and in tumor microenvironment
Authors: Alan Saadet , Karadag Nese , Akatlı Ayse Nur , Tecellioglu Fahriye Secil , Sahin Nurhan , Huz Mustafa 
Published: July 2023

Objectives:
Annexin A1 (ANXA1) which plays a role in tumor development and metastasis has been reported to be an effective regulator for tumor stroma and interacts with different components in the tumor microenvironment. The role of ANXA1 in tumorigenesis has not been fully understood. One of the main reasons for this is the great variability of ANXA1 expression in malignant tumors across different tumor types.

Materials and Methods:
Archived hematoxylin-eosin stained preparations of lung adenocarcinoma, breast invasive ductal carcinoma, colonic adenocarcinoma, and prostatic acinar carcinoma were re-evaluated and tumor regions to be analyzed with the tissue microarray method were determined. The ANXA1 expressions between the tumors and tumor microenvironment were evaluated immunohistochemically.

Results:
ANXA1 expression was decreased in the lung, breast, colon, and prostate adenocarcinomas. The most prominent staining was seen in lung adenocarcinoma cases. There was no statistically significant difference between the tumors in terms of ANXA1 staining (P > 0.05). ANXA1 was shown to be a more stained tumor microenvironment than in the tumor. Statistically significant staining with ANXA1 between within tumor and tumor microenvironment was observed in breast adenocarcinomas (P < 0.05). Our study showed differences between ANXA1 expression in different cancers, in tumor cells, and tumor microenvironment.

Conclusion:
Considering the effects of ANXA1 on tumor development and metastasis, a potential use as a biomarker may be suggested. Particularly, in breast adenocarcinomas, the high expression of ANXA1 in the tumor microenvironment supports the notion that it could induce the tumor stroma response.
ANATOLY FYODOROVICH KONI AS POLITICIAN
Authors: Рыбин Д.В. 
Published: July 2023

В статье раскрывается неизвестная страница из жизни выдающегося российского юриста А.Ф. Кони. Общественный деятель такого масштаба не мог не оказывать политического влияния на государственную систему. Само политическое мировоззрение юриста формировалось постепенно во второй четверти XIX в. и её можно отнести к сфере либерального легализма (консервативного либерализма). Конфликт с консервативным крылом государственной элиты в 1890-е гг. привёл Кони в стан умеренных оппозиционеров власти. Политические опыты сенатора привели его к активному участию в событиях первой русской революции. Он не только поощрял создание консервативно-либеральных партий, но и вёл активную переписку с крупными политическими фигурами и общественными деятелями о совместных действиях. В конечном счёте после отказа войти в «общественное правительство» Кони выбрал не публичную политику, а привычную ему подковёрную борьбу в государственном аппарате империи.
The article reveals an important but unknown page in the life of the outstanding Russian lawyer An. F. Koni. A public figure of this magnitude could not but exert political influence on the state system. The very political worldview of a lawyer was formed gradually in the second quarter of the 19th century and can be attributed to the sphere of liberal legalism (conservative liberalism). The conflict with the conservative wing of the state elite in the 1890s brought Anatoly Fedorovich into the camp of moderate opposition to the authorities. The senator's political experiences led him to take an active part in the events of the first Russian revolution. He not only encouraged the creation of conservative-liberal parties, but also actively corresponded with major political figures and public figures about joint actions. Ultimately, after refusing to enter the "public government", Koni chose not public politics, but his usual "undercover" struggle in the state apparatus of the empire.
MEDIEVAL JEWELRY OF THE SLAVIC PEOPLES: JEWELERY (COMPARATIVE ANALYSIS)
Authors: Жилина Н.В. 
Published: July 2023

Статья посвящена характеристике ювелирной стадии убора из украшений славянских народов (IX–XV вв.). Автор показывает, что в славянских государствах в процессе восприятия византийского ювелирного дела и взаимодействия с ним был выработан общеславянский филигранный ювелирный набор. Сформировавшийся первоначально в Моравии, ювелирный убор, попадая вместе с выходцами из Моравии в другие славянские государства, перерабатывался, здесь устоялись отличные в деталях формы украшений. Показывается развитие в славянских государствах собственных технологических навыков, основа которых всё же оставалась византийской или моравской. Делается заключение, что в XI–XV вв. своеобразие уборов славянских народов усиливается: развиваются уборы разных ювелирных техник, формируются крупные объёмные головные подвески (колты), женский головной убор получает диадемную конструкцию, формируются женские короны.
The article is devoted to the characteristics of the jewelry stage of dressing from the adornments of the Slavic peoples (IX–XV centuries). The author shows that in the Slavic states, in the process of perception of Byzantine jewelry and interaction with it, a pan-Slavic filigree jewelry set was developed. Jewelry was formed in Moravia, then spread along with immigrants from Moravia to other Slavic states, here, in the process of its processing, forms of jewelry excellent in detail were established. It shows the development in the Slavic states of their own technological skills, the basis of which still remained Byzantine or Moravian. It is concluded that in the XI-XV centuries. The originality of the headwear of the Slavic peoples is intensifying: headdresses of various jewelry techniques are developing, large volumetric head pendants (colts) are being formed, women's headwear is getting a diadem design, women's crowns are being formed.
«A CHEST WITH A JEWELRY, AND IN IT...»: SETS OF WOMEN'S JEWELRY IN THE 14TH – 17TH CENTURIES
Authors: Степанова Ю.В. 
Published: July 2023

В статье рассматриваются комплекты женских ювелирных украшений XIV–XVII вв. на основании письменных источников и археологических материалов. Выделяются наиболее характерные предметы ювелирного убора. Для XIV–XV вв. это височные подвески (колтки и рясы), а также браслеты. В этом убор позднего средневековья сходен с домонгольским. Источники этого периода характеризуют, прежде всего, убор высших сословий. Для XVI–XVII вв. обязательными предметами ювелирного убора являлись серьги и перстни в большом количестве. На всем протяжении рассматриваемого периода базовые ювелирные украшения сочетались с шитыми ожерельями. В состав ларешной кузни входили мониста с крестами, которые являлись предметами личного благочестия, но в костюме широких слоев населения являлись одновременно украшениями и оберегами.
The article considers the sets of women's jewelry of the 14th – 17th centuries based on the written sources and archaeological materials. The most characteristic items of jewelry are highlighted. For the 14th – 15th centuries these are еру temporal pendants (koltki and ryasy), as well as bracelets. In this, the dress of the late Middle Ages is similar to the pre-Mongol. It is noted that the sources of this period characterize, first of all, the dress of the upper classes. For the 16th – 17th centuries the earrings and finger rings in large quantities were the essential attribute of the female attire. Throughout the period, the basic jewellery was paired with sewed necklaces. The jewelry sets included a monista (chain) with crosses. They were objects of personal piety, but in the costume of wide segments of the population they were both decorations and charms.
CULTURES OF PATRIOTISM DURING FIRST WORLD WAR. COLLECTION OF ARTICLES [ED. K.A. TARASOV; FOREWORD BY B.A. KOLONITSKY]. ST. PETERSBURG: PUBLISHING HOUSE OF THE EUROPEAN UNIVERSITY IN ST. PETERSBURG, 2020. – 318 P. (THE ERA OF WARS AND REVOLUTIONS; ISSUE 13)
Authors: Булдаков В.П. 
Published: July 2023

Из статей рецензируемого сборника видно, что, вопреки распространенным представлениям, отношение населения европейских стран к Первой мировой войне оказалось далеко не однозначным. Патриотические эмоции захватили лишь незначительную часть городского населения. Вместе с тем война способствовала развитию всевозможных фобий, чем воспользовалась официальная пропаганда. Все участники сборника так или иначе подтверждают, что патриотизм – феномен архаичный, неустойчивый и трудноуловимый. Легче перечислить его исторические проявления, нежели выявить закономерности активизации и развития. Патриотизмом скорее пользовались, нежели вдохновлялись. Как и в других странах, от верноподданничества массы ожидали от власти награды за «патриотизм». За «возвышенными» чувствами мог таиться вполне прагматичный расчет.
It can be seen from the articles in the collection under review that, contrary to popular belief, the attitude of the population of European countries to the First World War turned out to be far from unambiguous. Patriotic emotions captured only a small part of the urban population. At the same time, the war contributed to the development of all kinds of phobias, which official propaganda took advantage of. All the participants of the collection confirm that patriotism is an archaic, unstable and elusive phenomenon. It is easier to enumerate its historical manifestations than to identify patterns of activation and development. Patriotism was used rather than inspired. As in other countries, the masses expected rewards from the authorities for «patriotism» from loyalty. Behind the "lofty" feelings, a completely pragmatic calculation could lurk.
Bélgica y la guerra civil española: un nuevo estado de la cuestión
Authors: Vargas Visús Jorge , Lépine Nicolas 
Published: July 2023

Resumen
La guerra civil española no fue un acontecimiento aislado en el contexto de la Europa de Entreguerras. Sus efectos trascendieron las fronteras españolas e influyeron en la política y la sociedad de diferentes estados europeos. Bélgica no fue una excepción. Por ello creemos que analizar cómo la guerra de España impactó en el devenir del estado y la sociedad belgas contribuye a demostrar que las alternativas socio-políticas que presentes en España lo estaban también en otros países europeos. El estudio de la influencia de la guerra civil española sobre otros estados demuestra que la propia contienda debería ser analizada en el marco del contexto europeo. Este artículo proporciona lo que consideramos es un útil instrumento para futuras investigaciones. Se trata de un ensayo historiográfico que analiza los trabajos académicos que se ocupan de la cuestión del impacto de la guerra civil española en Bélgica. En él examinamos el alcance y los límites de las investigaciones realizadas hasta la fecha, así como los enfoques metodológicos utilizados, mostrando que todavía queda mucho por investigar.
Palabras clave
Guerra civil española, Bélgica, historiografía, investigaciones, estado de la cuestión
El imperio informal, de modelo a herramienta conceptual: estado de la cuestión para el estudio de la España del siglo XIX
Authors: Gómez Gastiasoro Mikel 
Published: July 2023

ResumenEn este artículo se estudia el impacto que la investigación en torno al concepto de “imperio informal” ha tenido en los estudios imperiales españoles. Desde que, a mediados del siglo XX, una serie de trabajos clave dieran desarrollo y difusión a dicho concepto, diferentes historiografías nacionales lo han empleado para analizar las relaciones de dominación sin necesidad de invasión y ocupación. En España se asistió a finales de los años noventa a una renovación de los estudios imperiales, que tomaron en consideración líneas de investigación afines al estudio del imperio informal. Sin embargo, ha sido en los últimos años cuando se ha dado un esfuerzo coordinado por emplear el concepto como una herramienta analítica del dispositivo imperial español en el siglo XIX. Este impulso resulta útil para señalar cuáles son las líneas de investigación más propicias y las limitaciones más importantes para desarrollar una investigación sobre la política exterior española del período bajo esta perspectiva.
Palabras claves
Imperio español, imperio informal, siglo XIX, estudios imperiales, renovación
Pendampingan Pencegahan dan Perawatan Cedera Olahraga Melalui Sport Massage pada Atlet PABERSI Kabupaten Jepara
Authors: Muhibbi Muhammad , Yogaswara Andre , Fariz Sayid , Pratama Yuda Editya 
Published: July 2023

Powerlifting is a sport with a very high risk of injury because frequent, high-volume and high-intensity training will strain the muscles. The Jepara Regency Pabersi Team in carrying out training camps and matches requires an expert in injury handling and care as well as sports massage so that when a sports injury occurs it can be handled immediately. This PKM activity aims to provide assistance in the prevention and maintenance of sports injuries and sport massage to Pabersi athletes in Jepara Regency who are conducting training camps in preparation for the 2023 Central Java Provincial Porprov competition. The method used is analysis and direct practice on each athlete. who need sports massage and treatment of injuries both due to spasm, over use, buildup of lactic acid as well as muscle and joint injuries. The activity participants were all Pabersi athletes from Jepara district, totaling 7 people. The results shows that there is an increase in achievements of Pabersi athletes in Jepara Regency.ABSTRAKOlahraga Angkat Berat merupakan olahraga yang resiko terjadinya cedera sangat tinggi dikarenakan seringnya latihan dengan volume dan intensitas yang tinggi akan membuat otot menjadi tegang. Tim Pabersi Kabupaten Jepara dalam melaksanakan pemusatan latihan dan pertandingan membutuhkan seorang ahli dalam penanganan dan perawatan cedera serta sport massage sehingga saat terjadi cedera olahraga bisa langsung tertangani. Kegiatan Pengabdian ini mempunyai tujuan memberikan pendampingan dalam pencegahan dan perawan cedera olahraga serta sport massage pada atlet Pabersi Kabupaten Jepara yang sedang melakukan pemusatan latihan dalam persiapan dan pertandingan Pra Porprov Jawa Tengah tahun 2023. Metode yang digunakan adalah analisis dan praktikum langsung pada masing-masing atlet yang membutuhkan sport massage dan penanganan cedera baik itu dikarenakan spasme, over use, penumpukan asam laktat serta cidera otot dan persendian. Peserta kegiatan adalah semua atlet Pabersi kabupaten Jepara yang terdiri dari 7 orang atlet. Hasil dari kegiatan ini menunjukkan adanya peningkatan prestasi atlet Pabersi Kabupaten Jepara.
Analisis Kesalahan Berbahasa pada Rubrik Surat Pembaca Koran Kompas Edisi April, Mei, Juni 2021
Authors: Hidayanto Adam , Indrariani Eva Ardiana , Mukhlis Mukhlis 
Published: July 2023

The purpose of this study is to describe the form of language errors in the reader's letter rubric in the May, June, July 2021 edition of the Kompas newspaper. The data collection methods and techniques used in this study were the method of listening to the technique of note taking. The data analysis method used the agih method and the lesap technique. The technique of presenting the results of data analysis uses formal and informal techniques.The results of this study indicate that there are language errors which include five errors, namely: (1) phonological errors, including changes in phonemes, omission of phonemes, addition of phonemes, use of capital letters, use of punctuation marks; (2) morphological errors include errors in omitting affixes, using affixes, reduplication, and composition; (3) syntax errors include phrases, clauses, sentences; (4) semantic errors include synonyms.ABSTRAKTujuan penelitian ini untuk mendeskripsikan wujud kesalahan berbahasa pada rubrik surat pembaca di surat kabar Kompas edisi mei, juni, juli 2021. Metode dan teknik pengumpulan data yang digunakan dalam penelitian ini adalah metode simak dengan teknik catat. Metode analisis data menggunakan metode agih dan teknik lesap. Teknik penyajian hasil analisis data menggunakan teknik formal dan informal. Hasil penelitian ini menunjukkan bahwa terdapat kesalahan berbahasa yang meliputi lima kesalahan, yaitu (1) kesalahan fonologi antara lain perubahan fonem, penghilangan fonem, penambahan fonem, penggunaan huruf besar, penggunaan tanda baca; (2) kesalahan morfologi meliputi kesalahan dalam pemghilangan afiks, penggunaan afiks, reduplikasi, dan komposisi; (3) kesalahan sintaksis meliputi frasa, klausa, kalimat; (4) kesalahan semantik meliputi sinonimi.
Peran Mediator Komunitas Dalam Upaya Penyelesaian Sengketa Pertanahan Melalui Pendekatan Kearifan Lokal Di Desa Dasan Tapen, Lombok Barat
Authors: Grindulu Lewis , Islam M. Hotibul , Zainuddin Muhammad 
Published: July 2023

Pasca terlaksananya kegiatan, diharapkan masyarakat mitra lebih mengedepankan penyelesaian sengketa pertanahan dengan difasilitasi oleh mediator komunitas yang menerapkan nilai-nilai kearifan lokal. Metode yang akan digunakan dalam pengabdian ini adalah metode penyuluhan hukum dan diskusi. Kegiatan penyuluhan hukum yang dilakukan pada tanggal 24 Juni 2023 dihadiri oleh peserta dari berbagai kalangan, diantaranya tokoh dan aparat desa, tokoh masyarakat, tokoh agama dan tokoh adat setempat yang merupakan mediator komunitas. Materi penyuluhan berkaitan kearifan lokal sebagai sarana penyelesaian sengketa pertanahan dan kedudukan mediator komunitas dalam hukum positif di Indonesia. Dampak positif dari kegiatan adalah adanya penguatan pengetahuan bagi mediator komunitas pada masyarakat mitra yang akan memfasilitasi sengketa pertanahan. Dengan demikian, diharapkan penyelesaian-penyelesaian sengketa yang berbasis win-win solution dengan mengedepankan nilai-nilai kearifan lokal senantiasa menjadi pilihan utama dalam penyelesaian sengketa pada masyarakat.