bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of neonatal sepsis and associated factors among neonates admitted in the neonatal intensive care unit at Lira Regional Referral Hospital, Northern Uganda
Authors: Katugume Brendah , Muzungu JohnBaptist , Okello Nelson , Kigongo Eustes , Namutebi Deborah Andrinar 
Published: January 2025

Background
Sepsis is one of the leading causes of mortality and morbidity among neonates. An estimated 5.29–8.73 million Disability-adjusted life years (DALYs) are lost annually in SSA due to neonatal sepsis (NS). Uganda registered stagnated neonatal mortality of 27 deaths per 1000 live births in 2020 of which 12% was attributed to NS. Early risk factor identification and improved obstetric care are proven to reduce deaths due to NS, yet there is scanty literature on the LRRH. We, therefore, determined the prevalence of NS and identified its associated factors within the LRRH of northern Uganda.

Methods
A hospital-based, cross-sectional study with a retrospective chart review was conducted in the neonatal intensive care unit (NICU) at Lira Regional Referral Hospital (LRRH), in northern Uganda. 194 records of neonates admitted to the NICU from September 2022 to February 2023 were reviewed. The participant records were selected by systematic sampling technique and a structured data extraction tool was used to collect data. Using SPSS version 25 data entry and analysis were done. The univariable analysis gave a general description of the data. Logistic regression analysis was used to show associations and the statistical significance was declared at a P value of 0.05 after multivariable analysis.

Results
Among a total of 194 neonates whose charts were reviewed, 80 neonates had neonatal sepsis, giving a proportion of 0.412 and then prevalence of 41.2%. Age in days of the neonate (AOR = 4.212, 95% CI: [1.627-10.903]) for neonates of 1-3days of age, sex where males (AOR = 2.09, 95% CI: [1.123-3.887]), an APGAR score of 1-4 at birth (AOR = 0.309, 95% CI: [0.115-0.831]) and weight at birth <2500g (AOR = 2.543, 95% CI: [1.381-4.683]) were significantly related to it.

Conclusions and recommendations
The results found the prevalence of NS among neonates admitted to the NICU of LRRH high at 41.2%. Factors 1-3 days of age, male sex, a birth weight of <2500g, and an Apgar score of 1-4 at birth among all neonates were significant. Therefore, it was suggested that caregivers ensure safe newborn care, detect infections early, and use prophylactic antibiotics for high-risk babies after birth, to reduce NS. Further research will be conducted on the major causative agents and outcomes of NS in the NICU of LRRH.
Solving the Capacitated Vehicle Routing Problem via Reinforcment Learning
Authors: Chen Aidan , Yarkony Julian 
Published: January 2025

This research focuses on solving the Capacitated Vehicle Routing Problem (CVRP), an NP-hard optimization problem critical for logistics companies aiming to minimize delivery costs while adhering to vehicle capacity constraints. Traditional approaches, such as heuristics and exact algorithms, struggle with scalability or accuracy. Leveraging reinforcement learning (RL), we implemented two strategies: a value-based Deep-Q approach and a policy-based REINFORCE method. The Deep-Q network approximates Q-values for state-action pairs, utilizing experience replay and Huber loss for stability and efficiency. The REINFORCE approach optimizes policies directly, bypassing temporal difference calculations and using cumulative rewards for policy updates.
Experiments were conducted on VRP instances with 20 and 50 customers, benchmarking against a greedy algorithm and a state-of-the-art attention-based solution. Both RL methods outperformed the greedy baseline, with REINFORCE achieving superior results, demonstrating its effectiveness in handling exploration-exploitation trade-offs. A pseudo actor-critic approach, combining strengths of both methods, and inference-time ensembling of multiple RL networks further improved performance, achieving costs within 12% and 7.9% of the attention-based model for VRP-20.
This work highlights the potential of RL in addressing high-dimensional CVRP challenges, including generalizability and policy optimization. Future directions include integrating attention mechanisms to enhance model performance and exploring training-time ensembling to reduce variance. This research establishes RL as a scalable and efficient alternative for complex routing problems, advancing the field toward practical, real-world applications
Bibliotheken als soziales Netzwerk Europas – die Europe Challenge 2024
Authors: Huck Cristine , Kropf Katrin , Schrewe Paula 
Published: January 2025

Zusammenfassung
Die European Cultural Foundation fördert Bibliotheken als soziale Treffpunkte in Europa. Im Rahmen der Europe Challenge-Förderung entwickeln Bibliotheken und ihre Community-Partner Projekte, um lokale Herausforderungen wie soziale Ungleichheit, ökologische Krisen und Einsamkeit anzugehen. Die teilnehmenden Bibliotheken werden unterstützt durch Workshops, Mentoring und finanzielle Mittel. In diesem Artikel berichten Bibliotheken aus Chemnitz, Frankfurt am Main und Paderborn von ihren Erfahrungen und ihrer Teilnahme an der Europe Challenge.
Athol Fugard’s Boesman and Lena: Unveiling the Coloured Ghost in South Africa
Authors: Mu Yu 
Published: January 2025

Abstract

Boesman and Lena, a play by Athol Fugard in 1969, explores the socio-political landscape of apartheid-era South Africa. The story centres on Boesman and Lena, a couple who are forcibly displaced from their home due to apartheid laws. This article examines how Fugard navigates the complexities of coloured history within South African modernity rather than through the lens of post-colonial discourse. It investigates Fugard’s use of modern theatre techniques, particularly his adaptation of Brecht’s Leichtigkeit, to portray the intricacies of human existence and societal tensions in his plays. Furthermore, the article discusses that Fugard’s effort offers a unique perspective on reconciling contrasting traditions within modern theatre. Further in his Fanonian anatomy of the psychology of coloured individuals, his theatre provides a remarkable narrative of South African modernity by depicting coloured people as a spectral experience of South African history and their shared humanity as a significant ideology that equals the Black Consciousness Movement.
Dynamic modeling and optimization of methanol partial oxidation to formaldehyde over Mo–Fe catalyst in an industrial isothermal reactor
Authors: Zakeri Gheshmi Hossein , Farsi Mohammad , Rahimpour Mohammad Reza 
Published: January 2025

Abstract
In this research, a one-dimensional heterogeneous model is developed to simulate the partial oxidation of methanol to formaldehyde over a molybdenum-iron catalyst in an industrial isothermal reactor at dynamic condition. The considered isothermal reactor is modelled based on the mass and energy balance equations considering catalyst deactivation. Based on the simulation results, decline in the catalyst activity from 1.0 to 0.73 decreases the rate of formaldehyde production rate from 94.9 kmol h−1 to 89.63 kmol h−1 during process run time. Subsequently, a multi-objective optimization problem is programmed to enhance formaldehyde productivity and minimize the production decline during process run time. To select the effective decision variables, a sensitivity analysis is performed based on the developed dynamic model. Then, the programmed multi-objective optimization problem is replaced with a single objective by the weighted sum method, and the problem is handled by the genetic algorithm method to determine the optimal trajectory of coolant temperature. The simulation results showed that the average formaldehyde production rate increases from 92.11 kmol h−1 to 95.22 kmol h−1 when the optimal conditions are applied to the reactor.
An a priori method for estimating the informativeness of the configuration of sensor placement when solving inverse problems of remote sensing
Authors: Lukyanenko Dmitry V. , Valiakhmetov Bulat I. , Tyrtyshnikov Eugene E. , Yagola Anatoly G. 
Published: January 2025

Abstract
The question of finding the optimal location and number of sensors is important when solving applied inverse problems of remote sensing. An incorrect answer to this question can significantly affect (1) the accuracy of reconstructing the unknown parameters of the object under study, and/or (2) the computational complexity of the inverse problem being solved. The work proposes an economical algorithm that allows among all equivalent (in the sense of the computational complexity of obtaining a solution to the inverse problem) sensor configurations, to select the one that will give a more accurate result when processing experimental data. This algorithm also allows to make a conclusion about whether it is really necessary to process all the experimental data obtained in the experiment, or whether it is possible to limit ourselves to only part of them without a significant loss of accuracy in the reconstructed solution. The algorithm is based on (1) the application of the mosaic-skeleton approximation method to the matrix of the system of equations to which the inverse problem being solved is reduced, and (2) the calculation of the compression rate of the approximating matrix relative to the original dense matrix for a given permissible relative approximation error. Thus, the algorithm is a priori, that is, it does not require a preliminary search for a solution to the inverse problem for the sensor configuration under study. Moreover, if the formulas that define the elements of the system matrix are known, then the algorithm requires the calculation of not all of these elements, but only part of them.
Discourses of division during the cost-of-living crisis: digital popular culture responds to governmental actions
Authors: Way Lyndon C. S. 
Published: January 2025

Abstract
The global 2023 economic slowdown contributed to a cost-of-living crisis that has impacted the daily lives of many, it being a structural and ‘well-being emergency’. Governments respond differently, based in part on political orientation and election cycles. The UK Conservative government, accused of leaning on populist discourses, responded in part with its 2023 budget. This paper uses Multimodal Critical Discourse Studies to investigate how a music mash up shared widely on social media criticises the UK government’s response, digital popular culture being a vital form of political participation and activism today. I examine lexica, images and musical sounds to reveal how government actions are ‘recontextualised’, that is, transformed through deletions, rearrangements, substitutions, and additions. Analysis provides a lens into what issues and events are raised and how these are articulated through divisive discourses. It is through this close reading that I consider digital popular culture’s roles in society.
Social Economy and Public Private Partnerships: Analysis, Drivers, and Prospects from the Local Level for Territorial Development
Authors: Catala Belen , Savall Teresa , Chaves-Ávila Rafael 
Published: January 2025

Abstract
Public private partnerships (PPPs) have traditionally foster collaboration between public administrations and private actors in terms of efficiency and risk sharing. Recent approaches emphasize aligning PPPs with sustainability and social value goals. This study explores PPPs with social economy entities at the local level and its impact to the territory by examining cases in energy, housing, and digitalization in the region of Valencian Community (Spain). The research identifies drivers, benefits, and obstacles in its implementation, showcasing pioneering cases as models for sustainable growth and achieving a green and digital transition. It highlights positive territorial impacts, the promotion of social innovation and the alignment with Sustainable Development Goals.
Coconstruction d’une approche didactique de la littérature au collégial : une démarche collaborative axée sur le transfert de connaissances
Authors: Bélec Catherine , Doré Roxane 
Published: January 2025

Les cours de littérature de la formation obligatoire du collégial poursuivent des visées éducatives qui sont difficilement atteintes selon les personnes enseignant la discipline. Bien que plusieurs connaissances issues de la recherche fournissent des pistes pour améliorer la réussite éducative dans ces cours, un faible transfert dans les pratiques est observé. L’approche développée dans le cadre de cette recherche a été élaborée en coconstruction afin de faciliter ce transfert. L’approche « Enseigner la lecture littéraire au collégial » (ELLAC) opérationnalise plusieurs savoirs théoriques dans une optique de réussite éducative. La démarche fait aussi émerger l'importance des dimensions axiologiques dans les entreprises de reconfigurations disciplinaires.
Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing’s syndrome
Authors: Wolf Peter , Travers Simon , Domenig Oliver , Baron Stephanie , Blanchard Anne , Bouazizi Khaoula , Kachenoura Nadjia , Salenave Sylvie , Poglitsch Marko , Redheuil Alban , Trabado Severine , Young Jacques , Chanson Philippe , Kamenický Peter 
Published: January 2025

Background
Arterial hypertension and left ventricular hypertrophy and remodeling are independent cardiovascular risk factors in patients with Cushing’s syndrome. Changes in the renin–angiotensin system and in the mineralocorticoid axis activity could be involved as potential mechanisms in their pathogenesis, in addition to cortisol excess.

Methods
In this ancillary study of our previous study prospectively investigating patients with ACTH-dependent Cushing’s syndrome by cardiac magnetic resonance imaging (NCT02202902), 11 patients without any interfering medication were cross-sectionally compared to 20 control subjects matched for age, sex and body mass index. Angiotensin metabolites and adrenal steroids were measured by liquid chromatography tandem mass spectrometry, and their relation to blood pressure and cardiac structure was evaluated.

Results
Concentrations of angiotensin I and angiotensin II were comparable, but the angiotensin-converting enzyme activity was significantly lower (2.19 (1.67; 3.08) vs 4.07 (3.1; 5.6); P < 0.001) in patients compared to controls. Aldosterone concentrations were significantly lower (6.9 (6.9; 124.1) vs 239.9 (181.4; 321.9) pmol/L; P < 0.001) in the group of patients, but adrenal aldosterone precursor metabolites were comparable between patients and controls. Inverse correlations were observed for 24 h urinary free cortisol and aldosterone with the ratio of left ventricular mass to end-diastolic volume (r = 0.470, P = 0.012 and r = −0.367, P = 0.046, respectively).

Conclusions
We describe a disease-specific profile of angiotensin metabolites in patients with ACTH-dependent Cushing’s syndrome. Low levels of aldosterone in the presence of unchanged precursor metabolites indicate a direct inhibitory action of cortisol excess on the aldosterone synthase. Furthermore, glucocorticoid excess per se drives cardiac muscle remodeling.
Assessment of Natural Radioactivity in a Residence in Belo Horizonte
Authors: Sueli da Conceição Teixeira Coelho  , Santos T.O. , Takahashi L. C. , Ferreira I. N. S. , Passos R. G. 
Published: January 2025

Natural radioactivity comes from natural radionuclides present in rocks and soil and from cosmic rays. In addition to gamma-emitting radionuclides, radon stands out, which is a carcinogenic gas. In nature, radon occurs as radioisotopes: 222Rn (half-life time, t1/2,of 3.83 d), 219Rn (t1/2 = 3.92 s) and 220Rn (or thoron, t1/2 = 54.5 s). The World Health Organization (OMS) recommends that it be measured in homes, with the recommended limit being 100 Bq/m3 and the maximum limit being 300 Bq/m3. This work evaluates the origin of natural radiation in a residence in Belo Horizonte, Minas Gerais, Brazil, in which was observed radon concentrations above the limits established by the OMS. The detectors used were: nuclear trace detectors type CR-39, electrets (E-PERM), AlphaGUARD (AG) and the detector RS-230. The result of the 222Rn concentration measured in the electrets in the rooms of the residence varied from 14,8 Bq/m3 to 932 Bq/m3. At this highest point, the result of the average concentration of AlphaGUARD was from 4.78 kB/m3, with a maximum value of 8.5 kBq/m3. The concentration of 220Rn varied Bq/m3 Bq/m3. As this is a basement-type room, the bedroom next door was investigated, in which it is highlighted that the radon concentration of the detector CR-39 was from 445 Bq/m3, AG of 198.2 Bq/m3 with a maximum value of 350 Bq/m3, and electret of 29.6 Bq/m3. Gamma scanning with the RS-230 indicates higher counts on uncoated walls. Measurements of radon in the water showed background concentrations. It is concluded that poor ventilation of the location must be the biggest contributor to the high concentration of 222Rn, which originates mainly from the soil. The thoron concentration was higher in construction materials due to the measurement method. The instrumentation used allows a complete and comparative study between detectors in order to find the origin of natural radionuclides and subsequently suggest appropriate mitigation measures. In future studies, radon concentration in the soil and radon progeny will be measured.
Inhibition of Human Acetylcholinesterase (4EY7) using Bioactive Compound from Moringa oleifera: Molecular Docking and Dynamic Studies
Authors: Utami Wiji , Apriyanto Apriyanto , Antari Laila , Rasyid Herlina , Fitriani Ika Nur 
Published: January 2025

Alzheimer's disease is a neurodegenerative disorder caused by acetylcholine hydrolysis that impairs cognitive brain function. This research aims to determine the interaction and dynamic of ligands from Moringa oleifera on AChE through Lipinski's Rule, ADMET properties, molecular docking calculations, and molecular dynamic simulations. Lipinski's Rule calculation provided ligand limits that adhere to druglikeness properties. ADMET results also showed that several ligands satisfy ADMET properties. Pterygospermine has lower binding energy than the ligand control (-10.28 kcal mol-1) with amino acid residues of TYR133 and GLU202. It indicates a favorable interaction between the AChE receptor and ligand in the inhibition process. Based on molecular docking calculations, pterygospermine inhibits the AChE receptor at the Long, narrow aromatic gorge active site. According to molecular dynamic simulations, the MMPBSA energy for pterygospermine is 37.377 kJ mol-1. The samples showed a total average RMSD of 2 Å, suggesting no significant conformational changes throughout the simulation. The sample's average RMSF value is around 2 Å, suggesting favorable interactions with the receptor during simulation. However, this data is different from the ligand control interaction mode. Molecular dynamic investigations of the pterygospermine ligand in the complex revealed the stability and unfolded effect on the protein. The results of this study propose a candidate anti-Alzheimer's ligand from Moringa oleifera against the AChE receptor. In practice, these results can contribute to research studies exploring natural ingredients from plants with medicinal potential in drug discovery. These results can be validated using further research in vitro and in vivo.
Caregiver and Child Adverse Childhood Experiences: A Meta-Analysis
Authors: Zhu Jenney , Deneault Audrey-Ann , Turgeon Jessica , Madigan Sheri 
Published: January 2025

CONTEXT
Exposure to adverse childhood experiences (ACEs) is associated with adverse impacts on subsequent generations. The extent to which caregiver ACEs are associated with their child’s ACE score is unclear.

OBJECTIVE
To meta-analytically examine the association between caregiver and child ACE score. Potential moderators of this association were explored.

DATA SOURCES
Systematic searches were conducted using MEDLINE, Embase, PsycINFO, and CINHAL from 1998, the year the ACEs questionnaire was published, to February 19, 2024.

STUDY SELECTION
Inclusion criteria were that the ACEs questionnaire was completed for both caregiver and child, an effect size was available, and the study was published in English.

DATA EXTRACTION
Variables extracted included sample size and magnitude of association between caregiver ACEs and child ACEs, mean caregiver and child age, sex (% female), race and ethnicity, and informant of ACEs.

RESULTS
Seventeen samples (4872 caregiver-child dyads) met inclusion criterion. Results revealed a large pooled-effect size between caregiver and child ACEs (r = 0.33; 95% CI, 0.25–0.41; P &lt; .001), such that higher caregiver ACEs score was associated with higher child ACEs score. This association was stronger among studies with younger caregivers and studies that utilized caregiver-report compared with child self-report of ACEs.

LIMITATIONS
Many studies were conducted in North America with female caregiver samples, limiting generalizability beyond these populations.

CONCLUSIONS
Caregiver ACEs were strongly associated with child ACEs. Prevention and intervention efforts for caregivers should be trauma informed and focused on bolstering protective factors that may break cycles of intergenerational risk.
ESTADO NUTRICIONAL DO MARACUJAZEIRO AMARELO IRRIGADO E SUBMETIDO A ADUBAÇÃO ORGANOMINERAL
Authors: Medeiros Sherly Aparecida da Silva , Nascimento José Adeilson Medeiros do , Bezerra Marlene Alexandrina Ferreira , Cavalcante (im) Lourival Ferreira , Bezerra Francisco Thiago Coelho , Ferreira Clemilton da Silva 
Published: January 2025

ESTADO NUTRICIONAL DO MARACUJAZEIRO AMARELO IRRIGADO E SUBMETIDO A ADUBAÇÃO ORGANOMINERAL

SHERLY APARECIDA DA SILVA MEDEIROS1; JOSÉ ADEILSON MEDEIROS DO NASCIMENTO2; LOURIVAL FERREIRA CAVALCANTE3 (in memoriam); MARLENE ALEXANDRINA FERREIRA BEZERRA4, FRANCISCO THIAGO COELHO BEZERRA5 E CLEMILTON DA SILVA FERREIRA6

1Doutora, Programa de Pós-Graduação em Agronomia, Universidade Federal da Paraíba, Rodovia 079 -Km 12 – Caixa Postal 66 – Cep: 58397-000, Areia, Paraíba – Brasil, sherly.agro@hotmail.com
2Departamento de Agricultura, Instituto Federal do Ceará, Campus-Tianguá. Avenida Tabelião Luiz Nogueira de Lima SN, Bairro: Santo Antônio, Cep: 62324-079, Tianguá, Ceará – Brasil, adeilson.nascimento@ifce.br
3Pós graduação em Agronomia, Universidade Federal da Paraíba, Rodovia 079 - Km 12 – Caixa Postal 66 – Cep: 58397-000, Areia, Paraíba – Brasil, lofeca1946@yahoo.com.br
4Doutora, Programa de Pós-Graduação em Agronomia, Universidade Federal da Paraíba, Rodovia 079 -Km 12 – Caixa Postal 66 – Cep: 58397-000, Areia, Paraíba – Brasil, marlene_agro@hotmail.com
5Bolsista DCR-Fapesq-CNPq, Programa de Pós-Graduação em Agronomia, Universidade Federal da Paraíba, Rodovia PB 079 - Km 12, CEP: 58.397-000, Areia, Paraíba, Brasil, bezerra_ftc@yahoo.com.br
6Departamento de Agricultura, Instituto Federal do Ceará, Campus-Tianguá. Avenida Tabelião Luiz Nogueira de Lima SN, Bairro: Santo Antônio, Cep: 62324-079, Tianguá, Ceará – Brasil, clemil@ifce.edu.br
*Artigo oriundo da Tese de Doutorado de Sherly Aparecida da Silva Medeiros: “Fertilidade do solo, nutrição, fisiologia e produção do maracujazeiro amarelo sob irrigação e adubação organomineral”. UFPB, 2018.

1 RESUMO

Palavras-chave: Passiflora edulis, nutrição, insumo orgânico.

MEDEIROS, S. A. S.; NASCIMENTO, J. A. M.; CAVALCANTE, L. F.; BEZERRA, M. A. F.; BEZERRA, F. T. C.; FERREIRA, C. S.
NUTRICIONAL STATUS OF IRRIGATED YELLOW PASSION FRUITS UNDER ORAGNOMINERAL FERTILIZATION

2 ABSTRACT

Keywords: Passiflora edulis, nutrition, organic input.