bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric of the interpersonal communication skills scale: A confirmatory factor analysis
Authors: Salahshouri Arash , Fathi Sheida , Jiba Mostafa , Mohamadian Hashem 
Published: May 2023

Abstract
Background: In order to improve patient outcomes, healthcare professionals' communication skills need to be evaluated. A valid, culturally appropriate, and endemic scale for assessing interpersonal communication skills among the staff of comprehensive health centers in Iran was examined to achieve such an objective.
Materials & methods: A convenience sampling was used in November and December 2021 to collect information from 170 voluntary healthcare staff. The questionnaire had 30 items and seven factors. First- and second-order confirmatory factor analysis was used to validate the scale. Model fit was evaluated with GFI, AGFI, CFI, NFI, SRMR, RMSEA, and CN indices during confirmatory factor analysis. Discriminant validity was measured through Fronell-Larcker Criterion. Data were analyzed using Lisrel 8.8 & Smartpls 3.2.8 software.
Results: The predictive power of the model using the Q2-index based on the blindfolding test was equal to % 44. The first-order CFA results indicated that the indices had an acceptable value(χ2= 767.17; DF=375; CFI=0.98; GFI=0.82; AGFI=0.80; NFI=0.97; SRMR=0.22; CN= 127.83; RMSEA=0.068). Also, the fit indices of the second-order measurement model demonstrated the the adequacy and their desirability. (χ2= 797.24; DF=381; CFI=0.98; GFI=0.82; AGFI=0.78; NFI=0.97; SRMR=0.059; CN= 127.33; RMSEA=0.068). In terms of the importance-performance map analysis, the general and listening skills had the highest scores.
Conclusion: To develop interpersonal communication skills among healthcare staff, this scale could be useful. The results will need to be compared after further evaluation. It proposes to replicate skills training programs in other populations to determine their effectiveness.
Sparsity-Aware Distributed Adaptive Filtering with Robustness Against Impulsive Noise and Low SNR
Authors: Carmo Rafael Moura , Ferreira Guilherme R. , Campelo Pedro Henrique , Resende Leonardo C. , Lima Leonardo , Henriques Felipe Rocha , Haddad Diego Barreto 
Published: May 2023

Abstract
Distributed inference tasks could be performed by adaptive filtering techniques. Several enhancement strategies for such techniques were proposed, such as sparsity-aware algorithms, coefficients reuse and correntropy-based cost functions in the case of impulsive noise. In this paper, a general framework based on La-grange multipliers for the derivation of sophisticated algorithms that incorporate most of these improvements is described. A new general identification algorithm is derived as an example of the proposed approach and its performance is assessed in a distributed setting.
Early use of Thymalfasin prevents progression of common COVID-19 infection to severe pneumonia
Authors: Wang Zirui , Wang Cong , Fei Xiaohua , Wu Haixing , Niu Peiqin , Shen Changxing 
Published: May 2023

Abstract
Introduction
Thymosin drugs are commonly used for the treatment of viral infections due to their immunomodulatory effects. Whether the use of thymosin drugs can reduce the rate of COVID-19 progression to severe pneumonia has not been well documented. The aim of the present study was to explore the clinical value of Thymalfasin in preventing COVID-19 progression to severe pneumonia by retrospective review of the clinical data of 338 inpatients with common COVID-19 infection who received treatment in our hospital.
Methods
The primary index of observation was whether progression to severe pneumonia occurred within a week after admission, and the secondary indexes were the length of hospital stay, time of negative conversion of COVID-19 antigen, the number of peripheral lymphocytes and white blood cells (WBC), and C-reactive protein (CRP) and procalcitonin (PCT) levels.
Results
The length of hospital stay of patients in Thymalfasin group was significantly shorter than that of patients in the control group (p < 0.01). Multivariate logistic regression analysis showed that the use of Thymalfasin was an independent protective factor affecting the progression to severe pneumonia. Multifactorial Cox model analysis indicated that negative conversion of COVID-19 antigen was significantly faster in patients using Thymalfasin and younger patients.
Conclusion
Thymalfasin can prevent progression of common COVID-19 infection to severe pneumonia via multiple immunity-enhancing and anti-inflammatory protective mechanisms. However, it is necessary to grasp the timing of treatment to achieve better therapeutic effects. The present study demonstrated that use of Thymalfasin within a week of confirmed diagnosis of COVID-19 infection could offer greater clinical efficacy.
Computational Modelling Studies on In Silico Missenses in COVID-19 proteins and their effects on Ligand-Protein Interactions*
Authors: Sule Laxmi , Gupta Swagata , Jain Nilanjana , Sapre Nitin S 
Published: May 2023

Abstract
The paper presents the incorporation of in silico missenses and studies the effect of missenses to understand its effect on the Ligand-Protein interactions, of COVID-19 protein. In silico protein-ligand interaction, studies are being used to understand and investigate the drug-likeness of various molecules. 19 novel COVID-19 proteins are designed by inducing in silico missenses by mutating N691 amino acid residue in 7bv2 protein, the only residue forming H-bond with the ligand molecule in the parent protein. The work illustrates the effects of in silico-induced mutation on various interactions such as H-Bond, VDW, π-alkyl interactions, and changes in the number and type of surrounding amino acid residues. The results have suggested a common pattern of behaviour on mutation with T, V, W, and Y. Further, it is observed that the number and type of amino acid residues increase on mutation, suggesting the effect of mutation on the ligand-protein binding.
NIR-activatable O2 self-supplying nanoplatform via enhanced ferroptosis against colorectal cancer resistance
Authors: Jiang Hao , Tian Hailong , Wang Zhihan , Li Bowen , Chen Rui , Luo Kangjia , Lu Shuaijun , Nice Prof. , Huang Prof. , Gao Feng 
Published: May 2023

Abstract
Background Colorectal cancer (CRC) is the second most deadly cancer worldwide, with chemo-resistance remaining a major obstacle in CRC treatment. Notably, the imbalance of redox homeostasis-mediated ferroptosis and the modulation of hypoxic tumor microenvironment are regarded as new entry points for overcoming the chemo-resistance of CRC.Methods We rationally designed a light-activatable oxygen self-supplying chemo-photothermal nanoplatform by co-assembling cisplatin (CDDP) and linoleic acid (LA)-tailored IR820 via enhanced ferroptosis against colorectal cancer chemo-resistance. In this nanoplatform, CDDP can produce hydrogen peroxide in CRC cells through a series of enzymatic reactions and subsequently release oxygen under near-infrared (NIR)-triggered photothermal to alleviate hypoxia. Additionally, the introduced LA can add exogenous unsaturated fatty acids into CRC cells, triggering ferroptosis via oxidative stress-related peroxidized lipid accumulation. Meanwhile, photothermal can efficiently boost the rate of enzymatic response and local blood flow, hence increasing the oxygen supply and oxidizing LA for enhanced ferroptosis.Results This nanoplatform exhibited excellent anti-tumor efficacy in chemo-resistant cell lines and showed potent inhibitory capability in nude mice xenograft models.Conclusions Taken together, this nanoplatform provides a promising paradigm via enhanced ferroptosis and alleviated hypoxia tumor microenvironment against CRC chemo-resistance.
Can Relationship Patterns Be Transferred?The Influence of Parent-Child Attachment on Interpersonal Harmony Among Adolescents
Authors: Ma Yue , Wu Jie , Zha Shi-qi , Zhang Lin-ran , Yang Chun 
Published: May 2023

Abstract

Objective: Based on attachment theory and ecological systems theory, this paper explores the impact of parent-child attachment on interpersonal harmony adolescents and the mechanism of psychological boundary and cognitive flexibility.
Methods: 505 adolescents were investigated by parent-child attachment questionnaire, psychological boundary questionnaire, cognitive flexibility questionnaire, and interpersonal comprehensive diagnostic scale, of which 51.5% were boys.
Results: Parent-child attachment was negatively predicted interpersonal relationships. In other words, the higher the level of parent-child attachment, the lower level of interpersonal disturbance, and the more harmonious the interpersonal relationship. Psychological boundary and cognitive flexibility play mediating roles between parent-child attachment and interpersonal harmony respectively, and the mediation effect accounted for 15.58% and 18.83% of the total effect respectively. The results support the parallel mediation model of parent-child attachment and interpersonal harmony among adolescents .
Conclusion: The results support the parallel mediation model of psychological boundary and cognitive flexibility between parent-child attachment and interpersonal harmony.
Selective impairment of attention function in human immunodeficiency virus-negative patients with early forms of neurosyphilis
Authors: He Caifeng , Yuan Tao , Yuan Lili , Wang Jun , Lu Xiaohong , Hu Wenlong , Qiang Di , Cui Yong , Ci Chao , Shang Xianjin 
Published: May 2023

Abstract
Background
Cognitive impairment is common in patients with late neurosyphilis (NS). However, the relationship between early forms of human immunodeficiency virus (HIV)-negative NS and cognitive decline remains poorly understood. Hence, this study aimed to explore the characteristics of attention functions (the main cognitive aspect) in HIV-negative patients with early forms of NS and their association with brain magnetic resonance imaging (MRI) abnormalities.
Methods
In this study, 31 HIV-negative patients without NS, 30 HIV-negative patients with early forms of NS, and 35 healthy controls were enrolled from September 2020 to November 2022. The attentional network test was used to evaluate the performance of three components of attention, namely, alerting, orienting, and executive control.
Results
Patients with early forms of NS showed poorer performance in orienting and alerting functions than those without NS (F = 6.952, P = 0.011 and F = 8.794, P = 0.004, respectively); however, no difference was observed in executive function between the two groups (F = 0.001, P = 0.980). Multivariate analysis of variance using the Bonferroni post-hoc test indicated that patients with NS exhibited less efficient orienting function (P = 0.023), alerting function (P = 0.003) but not executive function (P = 1.0) than those without NS. Moreover, compared with contemporary healthy controls, a significant difference in orienting function was observed in patients with NS (P < 0.001). The NS group comprised more patients with MRI abnormalities in the frontal lobes and/or the temporoparietal junction than the non-NS group (24/25 vs. 13/19, P = 0.032).
Conclusions
HIV-negative patients with early forms of NS demonstrated obvious orientation and alerting function impairment. Brain MRI abnormalities in the frontal and/or parietal lobes and/or the temporoparietal junction indicated the presence of potential neural structure and network priority barriers pertaining to selective attention deficit.
Health workers’ experience of providing second-trimester abortion care in Ethiopia: a qualitative study
Authors: McLean Emily , Blystad Astrid , Mirkuzie Alemnesh H. , Miljeteig Ingrid 
Published: May 2023

Abstract
Background
Second-trimester abortions are less common than abortions in the first trimester, yet they disproportionately account for a higher burden of abortion-related mortality and morbidity worldwide. Health workers play a crucial role in granting or denying access to these services, yet little is known about their experiences. Ethiopia has been successful in reducing mortality due to unsafe abortion over the past decade, but access to second trimester abortion remains a challenge. The aim of this study is to better understand this issue by exploring the experiences of second-trimester abortion providers working in Addis Ababa, Ethiopia.
Methods
A qualitative study with 13 in-depth semi-structured interviews with 16 health workers directly involved in providing second-trimester abortions, this included obstetrician and gynaecologist specialists and residents, general practitioners, nurses, and midwives. Data was collected at four public hospitals and one non-governmental clinic in Addis Ababa, Ethiopia and analysed using Malterud´s text-condensation method.
Results
The providers recognized the critical need for second-trimester abortion services and were motivated by their empathy towards women who often sought care late due to inequality and poverty making it difficult to access abortion before the second trimester. However, service provision was challenging, and barriers like lack of access to essential drugs and equipment, few providers willing to conduct abortions late in pregnancy and unclear guidelines were common. This led to very demanding working conditions. They experienced ethical dilemmas concerning the possible viability of the fetus and women desperately requesting the service after the legal limit.
Conclusions
Second-trimester abortion providers faced several barriers and ethical dilemmas pushing their moral threshold and medical risk-taking in an effort to deliver second-trimester abortions to vulnerable women in need of the service. Effort is needed to minimize health system barriers and improve guidelines and support for second-trimester abortion providers in order to increase access and quality of second-trimester abortion services in Ethiopia. The barriers forcing women into second trimester abortions also need to be addressed.
Genome-wide Identification and Expression analysis of the NRT Genes in Ginkgo biloba under nitrate treatment reveal the potential roles during calluses browning
Authors: Feng Jin , Zhu Can , Cao Jiaqi , Liu Chen , Zhang Jiaqi , Cao Fuliang , Zhou Xiaohong 
Published: May 2023

Abstract
Nitrate is a primary nitrogen source for plant growth, and previous studies have indicated a correlation between nitrogen and browning. Nitrate transporters (NRTs) are crucial in nitrate allocation. Here, we utilized a genome-wide approach to identify and analyze the expression pattern of 74 potential GbNRTs under nitrate treatments during calluses browning in Ginkgo, including 68 GbNPFs, 4 GbNRT2 and 2 GbNRT3. Conserved domains, motifs, phylogeny, and cis-acting elements were analyzed to demonstrate the evolutionary conservation and functional diversity of GbNRTs. Our analysis showed that the NPF family was divided into eight branches, with the GbNPF2 and GbNPF6 subfamilies split into three groups. Each GbNRT contained 108-214 CREs of 19-36 types, especially with binding sites of auxin and transcription factors MYB and bHLH. The E1X1X2E2R motif had significant variations in GbNPFs, indicating changes in the potential dynamic proton transporting ability. The expression profiles of GbNRTs indicated that they may function in regulating nitrate uptake and modulating the signaling of auxin and polyphenols biosynthesis, thereby affecting browning in Ginkgo callus induction. These findings provide a better understanding of the role of NRTs during NO3- uptake and utilization in vitro culture, which is crucial to prevent browning and develop an efficient regeneration and suspension production system in Ginkgo.
Robotic excision of parametrial endometriosis with the new Versius robotic system: a preliminary case series.
Authors: Gaia Giorgia , Afonina Margarita , Felline Mauro , Sighinolfi Maria Chiara , Terzoni Stefano , Maruccia Serena , Iannuzzi Veronica , Podda Martina , Alboni Carlo , Spinillo Arsenio , Marconi Anna Maria 
Published: May 2023

Abstract
Purpose: Endometriosis affects 10% of the female population in reproductive age. Although a greater awareness of the condition and constant progress in understanding its natural history, its treatment remain challenging. When it comes to surgical intervention, the minimally invasive, laparoscopic, or robotic approach is the gold standard. While offering better visualization and refinement of movements, the robotic system is burdened by often unaffordable costs. Since the Da Vinci patent expired, new platforms have entered this scene, trying to preserve the advantages of robotics, while cutting costs. To date, there are no deep infiltrating endometriosis cases reported in literature afforded with the new Versius surgical system.
Materials and methods: We considered prospectively 3 patients undergoing robotic surgery for parametrial endometriosis with the versius system, in our tertiary referral multiplatform robotic center. The surgical technique was described step by step. Demographics, intra-operative robotic events and peri-operative outcomes were collected.
Results: A total of 3 procedures were performed. The median BMI was 18.52 kg/m 2, [16.33-20.96]. The median age was 41 years [36-51]. Median docking time was 51 minutes [37-60], median console time 180 [136-223] minutes. Pneumoperitoneum was maintained at 9 mmHg. A single high priority collision occurred. Blood loss was negligible. There were no peri-operative complications nor conversions.
Conclusions: Versius appeared to be a safe and feasible option for deep infiltrating endometriosis surgery. Our experience suggests operative room configuration and port placement to better perform these challenging procedures. These suggestions may enhance the mini-invasiveness while beating costs and making robotics worldwide approachable.
Spectrum of Adjacency Matrix of Graphs in Cryptography
Authors: Pragathi Krishnaprabha.R 
Published: May 2023

Abstract
Having access to an elliptic curve with a specified number of points over a specific finite field isa prerequisite for many contemporary cryptography systems. The isogenies, which are surjectivemorphisms, play a significant role as specific mappings between these curves. Isogeny volcanoesare graphs with elliptic curves as their vertices and l-isogenies as their edges. Two identical ellipticcurves over Fq share the same trace t and cardinality. David Kohel examines the relationshipsbetweenisogenies of degreel and curves in Ellt(Fq ), the collection of curves defined over Fq withtrace t, in his thesis. More precisely, he describes the structure of the graph of l-isogenies definedon Ellt(Fq ).There is a relation between Isogeny graphs and orders in OK and uses modular poly-nomials to find the conductor of End(E). The connected components of this graphs are isogenyvolcanoes and it is possible to travel through these structures using modular polynomials, evenwithout knowing the cardinality of the curve.By using this information computation of the l-adicvaluation of the trace t, for l|g possible and hence obtain some information on the cardinality of thecurve. Isogeny graphs of supersingular elliptic curves plays a major role in cryptography.Isogenybased cryptography, studies cryptosystems whose security is based on the difficulty of finding apath in isogeny graphs of supersingular elliptic curves. This study investigates the use of graphadjacency matrices in maintaining the security of isogeny based key exchange protocols.
Research on the Motivation and Path Simulation of Collaborative Agglomeration of Chinese Culture and Tourism Industries Based on System Dynamics
Authors: Chi Yihan , Fang Yongheng , Liu Jiamin 
Published: May 2023

Abstract
This article is based on the dynamic system of collaborative agglomeration between culture and tourism industry, and uses a system dynamics model to explore the development path of collaborative agglomeration between Chinese culture and tourism industry. The results show: (1) Although China's shared collaboration between the cultural and tourism industries continues to increase year by year, this status quo development path is still considered slow. (2) Under the policy support path, the degree of collaborative agglomeration between China's cultural and tourism industries continued to increase year by year; however, after 2018, this path played a more significant role in promoting their development. (3) Under the economic support path, the degree of these industries’ agglomeration collaboration increased annually; however, after 2018, the growth rate gradually slowed down. (4) The policy-economic combination path has had the best promotion effect based on the cultural and tourism industries’ coordinated agglomeration development.
Technological Phases of Quantum Technologies Driving Long-Term Development
Authors: Coccia Mario , Roshani Saeed 
Published: May 2023

Abstract

The goal of this study is to develop a technology analysis for examining the evolutionary phases of some critical quantum technologies to explain on-going technological development. Method applies S-shaped model based on logistic function that is estimated with patent data to analyze the phases of quantum technologies over the course of their technological evolution. Findings reveal that the technological cycle of recent quantum technologies has a shorter period in emergence phase and a longer period in growth and maturity phases than older quantum technologies. In particular, structure of technological cycle also shows that for quantum technologies originated after 1980, technological phase of emergence (to reach to the point of growth) is reduced to 52% of the total length of the cycle, compared to 68% of technologies originated before 1980, whereas the growth and maturity phases for technologies originated after 1980 have a higher percentage weight on the total duration of the cycle than technologies originated before 1980: growth stage is 22.78% of total duration of cycle in new technologies originated after 1980 vs. 15.76% in older technologies originated before the 1980; maturity stage is 25.32% vs. 16.08%, respectively of total technological cycle. Results here can provide theoretical implications to explain dynamics and structure of the technological evolution of emerging quantum innovations that support the technological forecasting for improving decisions of R&D investments in specific technologies that can be major sources of next technological, industrial, economic and social change.