bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Composite Rheology on Plate‐Like Behavior in Global‐Scale Mantle Convection
Authors: Arnould Maëlis , Rolf Tobias , Manjón‐Cabeza Córdoba Antonio 
Published: August 2023

AbstractEarth's upper mantle rheology controls lithosphere‐asthenosphere coupling and thus surface tectonics. Rock deformation experiments and seismic anisotropy measurements indicate that composite rheology (co‐existing diffusion and dislocation creep) occurs in the Earth's uppermost mantle, potentially affecting convection and surface tectonics. Here, we investigate how the spatio‐temporal distribution of dislocation creep in an otherwise diffusion‐creep‐controlled mantle impacts the planform of convection and the planetary tectonic regime as a function of the lithospheric yield strength in numerical models of mantle convection self‐generating plate‐like tectonics. The low upper‐mantle viscosities caused by zones of substantial dislocation creep produce contrasting effects on surface dynamics. For strong lithosphere (yield strength > 35 MPa), the large lithosphere‐asthenosphere viscosity contrasts promote stagnant‐lid convection. In contrast, the increase of upper mantle convective vigor enhances plate mobility for lithospheric strength <35 MPa. For the here‐used model assumptions, composite rheology does not facilitate the onset of plate‐like behavior at large lithospheric strength.
MMS Observation of Two‐Step Electron Acceleration at Earth's Bow Shock
Authors: Lindberg M. , Vaivads A. , Raptis S. , Karlsson T. 
Published: August 2023

AbstractWe use the Magnetospheric Multiscale mission to observe a bi‐directional electron acceleration event in the electron foreshock upstream of Earth's quasi‐perpendicular collisionless bow shock. The acceleration region is associated with a decrease in wave activity, inconsistent with common electron acceleration mechanisms such as Diffusive Shock Acceleration and Stochastic Shock Drift Acceleration. We propose a two‐step acceleration process where an electron field‐aligned beam acts as a seed population further accelerated by a shrinking magnetic bottle process, with the shock acting as the magnetic mirror(s).
Continental Tip With Thinned Lithosphere and Thickened Crust Is a Favorable Location for Subduction Initiation
Authors: Zhang Shengxing , Leng Wei , Chen Ling 
Published: August 2023

AbstractThe collapse of passive margins and subsequent subduction initiation (SI) are key steps in the Wilson Cycle. However, the occurrence and mechanism of SI at passive margins have long been questioned due to the lack of Cenozoic observations. In this study, we propose that the continental tip, where arc/plateau blocks with thinned lithosphere and thickened crust accrete beside the passive margin, is a favorable location for SI. Our three‐dimensional numerical model and force analysis demonstrate that the continental tip, with its reduced frictional resistance and increased gravitational instability, is better suited for SI than other parts of the passive margin. Upon completion of SI, the retreat of self‐sustained subduction can create a transform plate boundary by tearing the passive margin. Our model explains why SI can occur at continental tips such as the Scotia and the Caribbean, as well as locations with similar tectonic settings, while most parts of the Atlantic margin remain stable over long geological periods.
Evaluating a Poroelastic Model via Pore Pressure Signals in Seafloor Sediments
Authors: Billings William Z. , Simeonov Julian , Calantoni Joseph 
Published: August 2023

AbstractBelow a certain threshold of wave energy for a given depth, unconsolidated sediment should respond to wave action poroelastically. To this end, a generalized simple poroelastic model was applied to in situ data collected in coastal sediments near Oceanside, California. Pore pressure data were recorded by sensors attached to cylindrical unexploded ordinance surrogates, and water pressure sensors on bottom moorings. Orientation data were collected from inertial motion units attached to the surrogates, which were placed on the seabed and subsequently shallow buried during a high‐energy event on 13 February 2021. The model is characterized by two parameters. A consolidation coefficient controls the depth of diffusive flow, and Skempton's coefficient represents the ratio of the original signal into components transmitted by the sediment matrix and the pore fluid. The model assumes that the pore pressure signal is coherent with the seafloor signal; spectral coherence above 0.75 was used to select the frequency range from 0.05 to 0.2 Hz for the analysis. Spectral analysis methods were then applied to obtain averaged auto spectral densities of the pore pressure and bottom mooring signals over the coherent frequency band. Attenuation between sensor pairs was calculated. The results yielded burial depths over time for the surrogates that agreed with changes in significant wave heights, liquefaction, and recovery depths.
Persistently Southward of the South Asian High During the Radiative Forcing Stabilization
Authors: Hou Hongyu , Qu Xia , Huang Gang 
Published: August 2023

AbstractThe South Asian high (SAH), a large‐scale anticyclone at 100 and 200 hPa on the Asian continent, is driven by South Asian summer monsoon rainfall and heating over the Tibetan Plateau. As one member of the Asian summer monsoon system, the changes of its location and intensity may cause other climate responses. Rainfall‐induced latent heating can affect the SAH change. Previous study revealed that rainfall responses in Indian Ocean are opposite in periods of increased and stabilizing radiative forcing (RF) due to the deep ocean warming over the Southern Ocean. SAH responses during RF increase and stabilization are studied with 13 models from the Extended Representative Concentration Pathway scenario 4.5 (ECP4.5) experiment. At 100 hPa, the SAH intensifies and moves equatorward in increased RF scenario; when RF stabilizing, SAH still shifts southward but with little change in intensity. At 200 hPa, the SAH changes little in both RF increase and stabilization. These opposite responses at different altitudes may be due to the maximum potential temperature at 150–200 hPa, leading to the opposite changes in vertical motion. Results of the linear baroclinic model indicate that (a) during RF increase, diabatic heating () contributes to SAH strengthening, both and the mean advection of stratification change (MASC) lead to SAH southward movement; (b) during RF stabilization, and MASC, contribute to the SAH equatorward displacement. Two components of , the latent heating and residual heating, are canceled out and lead to little change in SAH intensity.
Clinical impact of the genomic landscape and leukemogenic trajectories in non-intensively treated elderly acute myeloid leukemia patients
Authors: Jahn Ekaterina , Saadati Maral , Fenaux Pierre , Gobbi Marco , Roboz Gail J. , Bullinger Lars , Lutsik Pavlo , Riedel Anna , Plass Christoph , Jahn Nikolaus , Walter Claudia , Holzmann Karlheinz , Hao Yong , Naim Sue , Schreck Nicholas , Krzykalla Julia , Benner Axel , Keer Harold N. , Azab Mohammad , Döhner Konstanze , Döhner Hartmut 
Published: August 2023

AbstractTo characterize the genomic landscape and leukemogenic pathways of older, newly diagnosed, non-intensively treated patients with AML and to study the clinical implications, comprehensive genetics analyses were performed including targeted DNA sequencing of 263 genes in 604 patients treated in a prospective Phase III clinical trial. Leukemic trajectories were delineated using oncogenetic tree modeling and hierarchical clustering, and prognostic groups were derived from multivariable Cox regression models. Clonal hematopoiesis-related genes (ASXL1, TET2, SRSF2, DNMT3A) were most frequently mutated. The oncogenetic modeling algorithm produced a tree with five branches with ASXL1, DDX41, DNMT3A, TET2, and TP53 emanating from the root suggesting leukemia-initiating events which gave rise to further subbranches with distinct subclones. Unsupervised clustering mirrored the genetic groups identified by the tree model. Multivariable analysis identified FLT3 internal tandem duplications (ITD), SRSF2, and TP53 mutations as poor prognostic factors, while DDX41 mutations exerted an exceptionally favorable effect. Subsequent backwards elimination based on the Akaike information criterion delineated three genetic risk groups: DDX41 mutations (favorable-risk), DDX41wildtype/FLT3-ITDneg/TP53wildtype (intermediate-risk), and FLT3-ITD or TP53 mutations (high-risk). Our data identified distinct trajectories of leukemia development in older AML patients and provide a basis for a clinically meaningful genetic outcome stratification for patients receiving less intensive therapies.
E4orf1 improves adipose tissue-specific metabolic risk factors and indicators of cognition function in a mouse model of Alzheimer’s disease
Authors: Khan Md Shahjalal Hossain , Hefner Marleigh , Reddy Arubala , Dhurandhar Nikhil V. , Hegde Vijay 
Published: August 2023

Abstract
Objective
Obesity, impaired glycemic control, and hepatic steatosis often coexist and are risk factors for developing dementia, and Alzheimer’s disease (AD). We hypothesized that a therapeutic agent that improves glycemic control and steatosis may attenuate obesity-associated progression of dementia. We previously identified that adenoviral protein E4orf1 improves glycemic control and reduces hepatic steatosis despite obesity in mice. Here, we determined if this metabolic improvement by E4orf1 will ameliorate cognitive decline in a transgenic mouse model of AD.

Methods
Fourteen- to twenty-month-old APP/PS1/E4orf1 and APP/PS1 (control) mice were fed a high-fat diet. Cognition was determined by Morris Water Maze (MWM). Systemic glycemic control and metabolic signaling changes in adipose tissue, liver, and brain were determined.

Results
Compared to control, E4orf1 expression significantly improved glucose clearance, reduced endogenous insulin requirement and lowered body-fat, enhanced glucose and lipid metabolism in adipose tissue, and reduced de novo lipogenesis in the liver. In the brain, E4orf1 mice displayed significantly greater expression of genes involved in neurogenesis and amyloid-beta degradation and performed better in MWM testing.

Conclusion
This study opens-up the possibility of addressing glycemic control and steatosis for attenuating obesity-related cognitive decline. It also underscores the potential of E4orf1 for the purpose, which needs further investigations.
FANCA deficiency promotes leukaemic progression by allowing the emergence of cells carrying oncogenic driver mutations
Authors: Pawlikowska Patrycja , Delestré Laure , Gregoricchio Sebastian , Oppezzo Alessia , Esposito Michela , Diop M’ Boyba , Rosselli Filippo , Guillouf Christel 
Published: August 2023

AbstractLeukaemia is caused by the clonal evolution of a cell that accumulates mutations/genomic rearrangements, allowing unrestrained cell growth. However, recent identification of leukaemic mutations in the blood cells of healthy individuals revealed that additional events are required to expand the mutated clones for overt leukaemia. Here, we assessed the functional consequences of deleting the Fanconi anaemia A (Fanca) gene, which encodes a DNA damage response protein, in Spi1 transgenic mice that develop preleukaemic syndrome. FANCA loss increases SPI1-associated disease penetrance and leukaemic progression without increasing the global mutation load of leukaemic clones. However, a high frequency of leukaemic FANCA-depleted cells display heterozygous activating mutations in known oncogenes, such as Kit or Nras, also identified but at low frequency in FANCA-WT mice with preleukaemic syndrome, indicating that FANCA counteracts the emergence of oncogene mutated leukaemic cells. A unique transcriptional signature is associated with the leukaemic status of FANCA-depleted cells, leading to activation of MDM4, NOTCH and Wnt/β-catenin pathways. We show that NOTCH signalling improves the proliferation capacity of FANCA-deficient leukaemic cells. Collectively, our observations indicate that loss of the FANC pathway, known to control genetic instability, fosters the expansion of leukaemic cells carrying oncogenic mutations rather than mutation formation. FANCA loss may contribute to this leukaemogenic progression by reprogramming transcriptomic landscape of the cells.
Commonalities and differences in the mutational signature and somatic driver mutation landscape across solid and hollow viscus organs
Authors: Ng Aik Seng , Chan Dedrick Kok Hong 
Published: August 2023

AbstractAdvances in sequencing have revealed a highly variegated landscape of mutational signatures and somatic driver mutations in a range of normal tissues. Normal tissues accumulate mutations at varying rates ranging from 11 per cell per year in the liver, to 1879 per cell per year in the bladder. In addition, some normal tissues are also comprised of a large proportion of cells which possess driver mutations while appearing phenotypically normal, as in the oesophagus where a majority of cells harbour driver mutations. Individual tissue proliferation and mutation rate, unique mutagenic stimuli, and local tissue architecture contribute to this highly variegated landscape which confounds the functional characterization of driver mutations found in normal tissue. In particular, our understanding of the relationship between normal tissue somatic mutations and tumour initiation or future cancer risk remains poor. Here, we describe the mutational signatures and somatic driver mutations in solid and hollow viscus organs, highlighting unique characteristics in a tissue-specific manner, while simultaneously seeking to describe commonalities which can bring forward a basic unified theory on the role of these driver mutations in tumour initiation. We discuss novel findings which can be used to inform future research in this field.
Geospatial mapping of distribution grid with machine learning and publicly-accessible multi-modal data
Authors: Wang Zhecheng , Majumdar Arun , Rajagopal Ram 
Published: August 2023

AbstractDetailed and location-aware distribution grid information is a prerequisite for various power system applications such as renewable energy integration, wildfire risk assessment, and infrastructure planning. However, a generalizable and scalable approach to obtain such information is still lacking. In this work, we develop a machine-learning-based framework to map both overhead and underground distribution grids using widely-available multi-modal data including street view images, road networks, and building maps. Benchmarked against the utility-owned distribution grid map in California, our framework achieves > 80% precision and recall on average in the geospatial mapping of grids. The framework developed with the California data can be transferred to Sub-Saharan Africa and maintain the same level of precision without fine-tuning, demonstrating its generalizability. Furthermore, our framework achieves a R2 of 0.63 in measuring the fraction of underground power lines at the aggregate level for estimating grid exposure to wildfires. We offer the framework as an open tool for mapping and analyzing distribution grids solely based on publicly-accessible data to support the construction and maintenance of reliable and clean energy systems around the world.
On-shelf circulation of warm water toward the Totten Ice Shelf in East Antarctica
Authors: Hirano Daisuke , Tamura Takeshi , Kusahara Kazuya , Fujii Masakazu , Yamazaki Kaihe , Nakayama Yoshihiro , Ono Kazuya , Itaki Takuya , Aoyama Yuichi , Simizu Daisuke , Mizobata Kohei , Ohshima Kay I. , Nogi Yoshifumi , Rintoul Stephen R. , van Wijk Esmee , Greenbaum Jamin S. , Blankenship Donald D. , Saito Koji , Aoki Shigeru 
Published: August 2023

AbstractThe Totten Glacier in East Antarctica, with an ice volume equivalent to >3.5 m of global sea-level rise, is grounded below sea level and, therefore, vulnerable to ocean forcing. Here, we use bathymetric and oceanographic observations from previously unsampled parts of the Totten continental shelf to reveal on-shelf warm water pathways defined by deep topographic features. Access of warm water to the Totten Ice Shelf (TIS) cavity is facilitated by a deep shelf break, a broad and deep depression on the shelf, a cyclonic circulation that carries warm water to the inner shelf, and deep troughs that provide direct access to the TIS cavity. The temperature of the warmest water reaching the TIS cavity varies by ~0.8 °C on an interannual timescale. Numerical simulations constrained by the updated bathymetry demonstrate that the deep troughs play a critical role in regulating ocean heat transport to the TIS cavity and the subsequent basal melt of the ice shelf.
Characterization of the pig lower respiratory tract antibiotic resistome
Authors: Zhou Yunyan , Li Jingquan , Huang Fei , Ai Huashui , Gao Jun , Chen Congying , Huang Lusheng 
Published: August 2023

AbstractRespiratory diseases and its treatments are highly concerned in both the pig industry and human health. However, the composition and distribution of antibiotic resistance genes (ARGs) in swine lower respiratory tract microbiome remain unknown. The relationships of ARGs with mobile genetic elements (MGEs) and lung health are unclear. Here, we characterize antibiotic resistomes of the swine lower respiratory tract microbiome containing 1228 open reading frames belonging to 372 ARGs using 745 metagenomes from 675 experimental pigs. Twelve ARGs conferring resistance to tetracycline are related to an MGE Tn916 family, and multiple types of ARGs are related to a transposase gene tnpA. Most of the linkage complexes between ARGs and MGEs (the Tn916 family and tnpA) are also observed in pig gut microbiomes and human lung microbiomes, suggesting the high risk of these MGEs mediating ARG transfer to both human and pig health. Gammaproteobacteria are the major ARG carriers, within which Escherichia coli harbored >50 ARGs and >10 MGEs. Although the microbial compositions structure the compositions of ARGs, we identify 73 ARGs whose relative abundances are significantly associated with the severity of lung lesions. Our results provide the first overview of ARG profiles in the swine lower respiratory tract microbiome.
p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1
Authors: Shi Min Yan , Yu Hwang Chan , Han Chang Yeob , Bang In Hyuk , Park Ho Sung , Jang Kyu Yun , Lee Sangkyu , Son Jeong Bum , Kim Nam Doo , Park Byung-Hyun , Bae Eun Ju 
Published: August 2023

AbstractPPARα corepressor NCoR1 is a key regulator of fatty acid β-oxidation and ketogenesis. However, its regulatory mechanism is largely unknown. Here, we report that oncoprotein p21-activated kinase 4 (PAK4) is an NCoR1 kinase. Specifically, PAK4 phosphorylates NCoR1 at T1619/T2124, resulting in an increase in its nuclear localization and interaction with PPARα, thereby repressing the transcriptional activity of PPARα. We observe impaired ketogenesis and increases in PAK4 protein and NCoR1 phosphorylation levels in liver tissues of high fat diet-fed mice, NAFLD patients, and hepatocellular carcinoma patients. Forced overexpression of PAK4 in mice represses ketogenesis and thereby increases hepatic fat accumulation, whereas genetic ablation or pharmacological inhibition of PAK4 exhibites an opposite phenotype. Interestingly, PAK4 protein levels are significantly suppressed by fasting, largely through either cAMP/PKA- or Sirt1-mediated ubiquitination and proteasome degradation. In this way, our findings provide evidence for a PAK4-NCoR1/PPARα signaling pathway that regulates fatty acid β-oxidation and ketogenesis.
A reflection on polymer electrolytes for solid-state lithium metal batteries
Authors: Song Ziyu , Chen Fangfang , Martinez-Ibañez Maria , Feng Wenfang , Forsyth Maria , Zhou Zhibin , Armand Michel , Zhang Heng 
Published: August 2023

AbstractBefore the debut of lithium-ion batteries (LIBs) in the commodity market, solid-state lithium metal batteries (SSLMBs) were considered promising high-energy electrochemical energy storage systems before being almost abandoned in the late 1980s because of safety concerns. However, after three decades of development, LIB technologies are now approaching their energy content and safety limits imposed by the rocking chair chemistry. These aspects are prompting the revival of research activities in SSLMB technologies at both academic and industrial levels. In this perspective article, we present a personal reflection on solid polymer electrolytes (SPEs), spanning from early development to their implementation in SSLMBs, highlighting key milestones. In particular, we discuss the SPEs’ characteristics taking into account the concept of coupled and decoupled SPEs proposed by C. Austen Angell in the early 1990s. Possible remedies to improve the physicochemical and electrochemical properties of SPEs are also examined. With this article, we also aim to highlight the missing blocks in building ideal SSLMBs and stimulate research towards innovative electrolyte materials for future rechargeable high-energy batteries.
Divergent sequences of tetraspanins enable plants to specifically recognize microbe-derived extracellular vesicles
Authors: Zhu Jinyi , Qiao Qian , Sun Yujing , Xu Yuanpeng , Shu Haidong , Zhang Zhichao , Liu Fan , Wang Haonan , Ye Wenwu , Dong Suomeng , Wang Yan , Ma Zhenchuan , Wang Yuanchao 
Published: August 2023

AbstractExtracellular vesicles (EVs) are important for cell-to-cell communication in animals. EVs also play important roles in plant–microbe interactions, but the underlying mechanisms remain elusive. Here, proteomic analyses of EVs from the soybean (Glycine max) root rot pathogenPhytophthora sojaeidentify the tetraspanin family proteins PsTET1 and PsTET3, which are recognized byNicotiana benthamianato trigger plant immune responses. Both proteins are required for the full virulence ofP. sojae. The large extracellular loop (EC2) of PsTET3 is the key region recognized byN. benthamianaand soybean cells in a plant receptor-like kinase NbSERK3a/b dependent manner. TET proteins from oomycete and fungal plant pathogens are recognized byN. benthamianathus inducing immune responses, whereas plant-derived TET proteins are not due to the sequence divergence of sixteen amino acids at the C-terminal of EC2. This feature allows plants to distinguish self and non-self EVs to trigger active defense responses against pathogenic eukaryotes.
Constructing multiple active sites in iron oxide catalysts for improving carbonylation reactions
Authors: Liu Shujuan , Li Teng , Shi Feng , Ma Haiying , Wang Bin , Dai Xingchao , Cui Xinjiang 
Published: August 2023

AbstractSurface engineering is a promising strategy to improve the catalytic activities of heterogeneous catalysts. Nevertheless, few studies have been devoted to investigate the catalytic behavior differences of the multiple metal active sites triggered by the surface imperfections on catalysis. Herein, oxygen vacancies induced Fe2O3 catalyst are demonstrated with different Fe sites around one oxygen vacancy and exhibited significant catalytic performance for the carbonylation of various aryl halides and amines/alcohols with CO. The developed catalytic system displays excellent activity, selectivity, and reusability for the synthesis of carbonylated chemicals, including drugs and chiral molecules, via aminocarbonylation and alkoxycarbonylation. Combined characterizations disclose the formation of oxygen vacancies. Control experiments and density functional theory calculations demonstrate the selective combination of the three Fe sites is vital to improve the catalytic performance by catalyzing the elemental steps of PhI activation, CO insertion and C-N/C-O coupling respectively, endowing combinatorial sites catalyst for multistep reactions.