bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does kidney biopsy in pediatric lupus patients “complement” the management and outcomes of silent lupus nephritis? Lessons learned from a pediatric cohort
Authors: Mannemuddhu Sai Sudha , Shoemaker Lawrence R. , Bozorgmehri Shahab , Borgia R. Ezequiel , Gupta Nirupama , Clapp William L. , Zeng Xu , Modica Renee F. 
Published: January 2023

Abstract

Background
Silent lupus nephritis (SLN) is systemic lupus erythematosus (SLE) without clinical and laboratory features of kidney involvement but with biopsy-proven nephritis. This study aims to describe and compare the baseline characteristics and outcomes of pediatric SLN with overt LN (OLN) and to identify associated risk factors and biochemical markers.

Methods
In this retrospective, observational study, multivariate logistic regression and receiver operating characteristic (ROC) analyses studied age, sex, race, serum complements, anti-double-stranded-DNA antibody, anti-Smith antibody, eGFR, and proliferative nephritis.

Results
In our cohort of 69 patients, 47 were OLN, and 22 were SLN. OLN (OR = 4.9, p = 0.03) and non-African Americans (AA) (OR = 13.0, p < 0.01) had higher odds, and increasing C3 and C4 were associated with lower odds of proliferative nephritis (OR 0.95 and 0.65 per one unit increase in C3 and C4, respectively, p < 0.01). They demonstrated a good discriminative ability to detect proliferative nephritis as assessed by the area under the ROC curve (C3 = 0.78, C4 = 0.78). C3 and C4 in proliferative SLN and OLN were comparable and significantly lower than their non-proliferative counterparts. No association was observed between age, sex, anti-double-stranded-DNA antibody, anti-Smith antibody, eGFR, and proliferative nephritis. Proliferative SLN and OLN patients received similar treatments. Adverse events were identified in the proliferative OLN only.

Conclusions
Lower complement levels are associated with proliferative lesions in pediatric LN—both SLN and OLN. The non-AA population had higher odds of having proliferative nephritis than the AA. Prospective, randomized, long-term follow-up of proliferative SLN patients is needed to ascertain the beneficial effect of early diagnosis and treatment.

Graphical abstract
Fabric evolution and strain localisation in inherently anisotropic specimens of anisometric particles (lentils) under triaxial compression
Authors: Pinzón Gustavo , Andò Edward , Desrues Jacques , Viggiani Gioacchino 
Published: January 2023

AbstractInherent anisotropy is often observed in natural soils and other granular materials formed during gravity deposition. Fabric characterisation and evolution have been mainly studied using numerical simulations, given the difficulty of retrieving the contact network and the kinematics of particles in physical experiments. This work presents the results of five triaxial compression tests on inherently anisotropic lentil specimens imaged with x-ray tomography. Each specimen is prepared in a way such that all the particles present a unique mean orientation, as results from gravity in natural soils deposits - this can be called “bedding effect”. Particles are identified and tracked from the first image all the way through the test using a novel tracking algorithm, enabling the measurement of particle and contact fabric evolution, as well as strain localisation within the specimens. The results reveal that the deformation processes take place essentially in a planar scenario, both at a micro and mesoscale. Additionally, it is observed that under deviatoric loading two mechanisms are responsible for fabric evolution: rotation of the main orientation of the fabric tensor, and increase of the anisotropy. Finally, the orientation of the shear band is found to be independent of the initial orientation of the particles.Graphical abstract
The regional variation of a housing boom. Disparities of land prices in Austria, 2000–2018
Authors: Reiner Christian , Musil Robert 
Published: January 2023

AbstractDebates accompanying the global housing boom have primarily focussed on the economic and social implications for urban housing markets. Against this background, this paper analyses the repercussions for regional land prices of a national housing boom in and beyond agglomerations. Convergence and divergence dynamics, regional price drivers, and spatial diffusion are investigated by examining average building-land prices of 95 Austrian regions between 2000 and 2018. The results indicate a clear increase in regional disparities in land prices, with the main rise taking place during a high price-growth period. Regions with high land prices are the main drivers of divergence, while a substantial number of peripheral regions with converging land prices were hardly affected by the national price boom. Land-price growth rates are positively affected by the number of households but negatively impacted by income growth, which points to a problematic decoupling of household income and land prices. Finally, the diffusion of the land-price boom occurs along the urban hierarchy as well as via neighbouring regions, confirming the ripple-effect hypothesis.
Assessing regional variation in yield from weathered basement aquifers in West Africa and modelling their future groundwater development and sustainability
Authors: Bianchi Marco , Palamakumbura Romesh N. , MacDonald Alan M. , Macdonald David M. J. 
Published: January 2023

AbstractA data-driven modelling approach was applied to quantify the potential groundwater yield from weathered crystalline basement aquifers in West Africa, which are a strategic resource for achieving water and food security. To account for possible geological control on aquifer productivity, seven major geological domains were identified based on lithological, stratigraphic, and structural characteristics of the crystalline basement. Extensive data mining was conducted for the hydrogeological parameterisation that led to the identification of representative distributions of input parameters for numerical simulations of groundwater abstractions. These were calibrated to match distributions of measured yields for each domain. Calibrated models were then applied to investigate aquifer and borehole scenarios to assess groundwater productivity. Considering the entire region, modelling results indicate that approximately 50% of well-sited standard 60-m-deep boreholes could sustain yields exceeding 0.5 L/s, and 25% could sustain the yield required for small irrigation systems (> 1.0 L/s). Results also highlighted some regional differences in the ranges of productivities for the different domains, and the significance of the depth of the static water table and the lateral extent of aquifers across all geological domains. This approach can be applied to derive groundwater maps for the region and provide the quantitative information required to evaluate the potential of different designs of groundwater supply networks.
Flexural wave bandgap properties of phononic crystal beams with interval parameters
Authors: He Feiyang , Shi Zhiyu , Qian Denghui , Lu Y. K. , Xiang Yujia , Feng Xuelei 
Published: January 2023

AbstractUncertainties are unavoidable in practical engineering, and phononic crystals are no exception. In this paper, the uncertainties are treated as the interval parameters, and an interval phononic crystal beam model is established. A perturbation-based interval finite element method (P-IFEM) and an affine-based interval finite element method (A-IFEM) are proposed to study the dynamic response of this interval phononic crystal beam, based on which an interval vibration transmission analysis can be easily implemented and the safe bandgap can be defined. Finally, two numerical examples are investigated to demonstrate the effectiveness and accuracy of the P-IFEM and A-IFEM. Results show that the safe bandgap range may even decrease by 10% compared with the deterministic bandgap without considering the uncertainties.
Perilesional resection technique of glioblastoma: intraoperative ultrasound and histological findings of the resection borders in a single center experience
Authors: Giussani Carlo , Carrabba Giorgio , Rui Chiara Benedetta , Chiarello Gaia , Stefanoni Giovanni , Julita Chiara , De Vito Andrea , Cinalli Maria Allegra , Basso Gianpaolo , Remida Paolo , Citerio Giuseppe , Di Cristofori Andrea 
Published: January 2023

Abstract
Introduction
The surgical goal in glioblastoma treatment is the maximal safe resection of the tumor. Currently the lack of consensus on surgical technique opens different approaches. This study describes the “perilesional technique” and its outcomes in terms of the extent of resection, progression free survival and overall survival.

Methods
Patients included (n = 40) received a diagnosis of glioblastoma and underwent surgery using the perilesional dissection technique at “San Gerardo Hospital”between 2018 and 2021. The tumor core was progressively isolated using a circumferential movement, healthy brain margins were protected with Cottonoid patties in a “shingles on the roof” fashion, then the tumorwas removed en bloc. Intraoperative ultrasound (iOUS) was used and at least 1 bioptic sample of “healthy” margin of the resection was collected and analyzed. The extent of resection was quantified. Extent of surgical resection (EOR) and progression free survival (PFS)were safety endpoints of the procedure.

Results
Thirty-four patients (85%) received a gross total resection(GTR) while 3 (7.5%) patients received a sub-total resection (STR), and 3 (7.5%) a partial resection (PR). The mean post-operative residual volume was 1.44 cm3 (range 0–15.9 cm3).During surgery, a total of 76 margins were collected: 51 (67.1%) were tumor free, 25 (32.9%) were infiltrated. The median PFS was 13.4 months, 15.3 in the GTR group and 9.6 months in the STR-PR group.

Conclusions
Perilesional resection is an efficient technique which aims to bring the surgeon to a safe environment, carefully reaching the “healthy” brain before removing the tumoren bloc. This technique can achieve excellent tumor margins, extent of resection, and preservation of apatient’s functions.
Strigolactones: diversity, perception, and hydrolysis
Authors: Guercio Angelica M. , Palayam Malathy , Shabek Nitzan 
Published: January 2023

AbstractStrigolactones (SLs) are a unique and novel class of phytohormones that regulate numerous processes of growth and development in plants. Besides their endogenous functions as hormones, SLs are exuded by plant roots to stimulate critical interactions with symbiotic fungi but can also be exploited by parasitic plants to trigger their seed germination. In the past decade, since their discovery as phytohormones, rapid progress has been made in understanding the SL biosynthesis and signaling pathway. Of particular interest are the diversification of natural SLs and their exact mode of perception, selectivity, and hydrolysis by their dedicated receptors in plants. Here we provide an overview of the emerging field of SL perception with a focus on the diversity of canonical, non-canonical, and synthetic SL probes. Moreover, this review offers useful structural insights into SL perception, the precise molecular adaptations that define receptor-ligand specificities, and the mechanisms of SL hydrolysis and its attenuation by downstream signaling components.
Evaluating the response effort and data quality of established political solidarity measures: a pre-registered experimental test in an online survey of the German adult resident population in 2021
Authors: Goerres Achim , Höhne Jan Karem 
Published: January 2023

AbstractThis experimental study aims to check and improve the quality of 16 established survey measures of political solidarities and related concepts, such as redistribution and social trust. Political solidarities are defined as one’s willingness to share the costs that result from public redistribution that favours people other than oneself and thus constitute a subset of welfare state attitudes. The pre-registered study plan included suggestions for the development of improved rating scales, which we defined as five-point, end verbalized rating scales without non-substantive answer options. The overall results from an experimental online survey in Germany indicate differences in response effort in terms of response times but almost no differences in data quality in terms of criterion validity. Thus, the 16 survey measures show solid instrument validity as well as minor improvements in respondents’ response times. Indeed, the measures are (at least) in the online survey world of Germany of high-quality and warrant inclusion in future surveys with small efficiency gains still attainable.
Telomere Length: Implications for Atherogenesis
Authors: Yin Hao , Pickering J. Geoffrey 
Published: January 2023

Abstract

Purpose of Review
The purpose of the study is to explore the evidence linking telomere length with atherosclerotic ischemic disease.

Recent Findings
There has been a recent expansion in strategies for measuring telomere length, including analyzing genome sequence data and capitalizing on genomic loci that associate with telomere length. These, together with more established approaches, have been used to generate a more complete picture of telomere length relationships with ischemic disease. Whereas earlier meta-analyses suggested an association between short leukocyte telomeres and ischemic disease, several recent large population studies now provide particularly compelling data, including an association with cardiovascular mortality. In addition, whether short leukocyte telomeres might be causally related to ischemic disease has been interrogated using Mendelian randomization strategies, which point to shorter leukocyte telomeres as a determining risk factor. Importantly however, the wide, interindividual variability in telomere length still means that a single assessment of leukocyte telomere length in an individual does not reliably report on a biological aging process. In this regard, recent multi-tissue analyses of telomere length dynamics are providing both new mechanistic insights into how telomere length and shortening rates may participate in atherogenesis and risk prediction opportunities.

Summary
The balance of evidence indicates that short leukocyte telomeres confer a risk for atherosclerotic cardiovascular disease. Moreover, an integrated analysis of telomere lengths in leukocytes and other tissues may provide a window into individualized telomere dynamics, raising new prospects for risk management.
Why do humans need thrombospondin-1?
Authors: Kaur Sukhbir , Roberts David D. 
Published: January 2023

AbstractMatricellular proteins comprise several families of secreted proteins that function in higher animals at the interface between cells and their surrounding extracellular matrix. Targeted gene disruptions that result in loss of viability in mice have revealed critical roles for several matricellular proteins in murine embryonic development, including two members of the cellular communication network (CCN) gene family. In contrast, mice lacking single or multiple members of the thrombospondin (THBS) gene family remain viable and fertile. The frequency of loss of function mutants, identified using human deep exome sequencing data, provided evidence that some of the essential genes in mice, including Ccn1, are also essential genes in humans. However, a deficit in loss of function mutants in humans indicated that THBS1 is also highly loss-intolerant. In addition to roles in embryonic development or adult reproduction, genes may be loss-intolerant in humans because their function is needed to survive environmental stresses that are encountered between birth and reproduction. Laboratory mice live in a protected environment that lacks the exposures to pathogens and injury that humans routinely face. However, subjecting Thbs1−/− mice to defined stresses has provided valuable insights into functions of thrombospondin-1 that could account for the loss-intolerance of THBS1 in humans.
Graphical Abstract
Understanding passenger hostility in transit: a systematic review
Authors: Davis Melanie , Bradley Graham L. , Racz Jason I. , Ferguson Samantha , Buys Nicholas J. 
Published: January 2023

Abstract
Passenger hostility is commonplace in the transit industry. However, research investigating this job stressor is limited in both scope and quality. This systematic review examines three questions regarding passenger hostility: (a) what is its occurrence (incidence and prevalence); (b) what are its consequences; and (c) what factors are related to its occurrence, intensity, or consequences? Six databases were searched for studies published between 2010 and 2020 reporting the occurrence, consequences, or correlates of passenger hostility directed toward transit workers. Risk of bias was categorized using the Critical Appraisal Skills Programme. Results were summarized in tables and narratively synthesized. Nineteen eligible studies (10 quantitative and nine qualitative or mixed methods) were identified. Evidence from 14 studies indicated that passenger hostility occurs frequently, and is often underreported, especially in its less severe forms. Sixteen studies reported correlates of the occurrence, intensity, or consequences of hostility, with these grouped into worker, passenger, organizational, environmental, and event categories. Immediate and long-term impacts were identified in ten studies. This review contributes to understanding the likely antecedents, correlates and consequences of passenger hostility directed at transit industry workers. It also highlights some common methodological limitations in past research and proposes solutions to them. As such, the paper provides suggestions for future explorations and intervention targets aimed at reducing this common workplace stressor.
Modeling and pricing cyber insurance
Authors: Awiszus Kerstin , Knispel Thomas , Penner Irina , Svindland Gregor , Voß Alexander , Weber Stefan 
Published: January 2023

AbstractThe paper provides a comprehensive overview of modeling and pricing cyber insurance and includes clear and easily understandable explanations of the underlying mathematical concepts. We distinguish three main types of cyber risks: idiosyncratic, systematic, and systemic cyber risks. While for idiosyncratic and systematic cyber risks, classical actuarial and financial mathematics appear to be well-suited, systemic cyber risks require more sophisticated approaches that capture both network and strategic interactions. In the context of pricing cyber insurance policies, issues of interdependence arise for both systematic and systemic cyber risks; classical actuarial valuation needs to be extended to include more complex methods, such as concepts of risk-neutral valuation and (set-valued) monetary risk measures.
Managing sustainable practices and logistics value to improve customer loyalty: importers vs. freight forwarders
Authors: Justavino-Castillo Milva Eileen , Gil-Saura Irene , Fuentes-Blasco Maria , Moliner-Velázquez Beatriz , Servera-Francés David 
Published: January 2023

AbstractIn B2B context, this study focuses on analysing the loyalty formation process from a set of antecedent multidimensional variables—sustainable practices and logistics value—and the moderating effect of type of customer in maritime transport from the user’s perspective. Based on a sample of 105 importing companies and freight forwarders in Panama, a structural equation model was estimated to test the research hypotheses. The results show the significant influences of sustainable practices on value and value on loyalty. The significant mediating effect of value in the relationship between sustainable practices and loyalty is also verified. It indicates the benefits of the presence of perceived logistics value in B2B relationships since it reinforces the intensity of the links between sustainable practices and loyalty. The moderating role of the type of business was confirmed. Amongst importers, sustainable practices show a significantly greater impact on logistics value than in the freight forwarders group.
A participatory and multi-actor approach to locally support crop diversification based on the case study of camelina in northern France
Authors: Leclère Margot , Loyce Chantal , Jeuffroy Marie-Hélène 
Published: January 2023

Abstract
Despite the acknowledged benefits of crop diversification, the transition towards more diversified cropping systems needs to be supported, mainly due to socio-technical lock-ins favoring major dominant crop species. This calls for the development of new approaches to support the design of locally tailored diversified cropping systems. This paper aims to present an original participatory and multi-actor design approach, developed to support the introduction of camelina (Camelina sativa) into the cropping systems of northern France and to provide some insights about the characteristics, the specificities, and the limits of this approach to support its use and adaptation to other contexts. For 3 years, and in connection with the development of an oilseed biorefinery, we gathered a variety of actors (farmers, advisors, engineers in agronomy, researchers, and industrialists) to locally support the introduction of camelina in the cropping systems. First, we illustrate the diversity of the modalities that have been collectively imagined to introduce and manage camelina in the local cropping systems. Then, we describe the originality and the diversity of the knowledge produced on camelina, especially during the assessment of some of these modalities within on-farm experiments. Finally, drawing on concepts and theories from design sciences, we show that (i) the pre-existence of networks of actors, (ii) the rationale involvement of the actors, (iii) the implementation of a situated design process fueled by action and distributed among actors, (iv) the sharing and the circulation of knowledge among a diversity of actors involved in the production and use of the new crop, and (v) the implementation of an effective network management contributed to foster the three key elements that we identified as crucial to support crop diversification, namely, the production of actionable knowledge, the exploration of new ideas/concepts, and the active participation of a diversity of actors of the agri-food system.
Factors Affecting Rate of Pleural Fluid Accumulation in Patients with Malignant Pleural Effusions
Authors: Sethi Dheeraj K. , Kouritas Vasileios , Mishra Eleanor 
Published: January 2023

Abstract

Purpose of Review

Malignant pleural effusions (MPEs) are initially treated with thoracocentesis but usually reaccumulate. There is wide variation in the rate of recurrence. Those with rapid recurrence could benefit from early definitive treatment, whilst those with slower recurrences may not. Here, we discuss pleural fluid homeostasis, MPE pathophysiology, and factors associated with reaccumulation.

Recent Findings

Few studies have investigated markers of MPE reaccumulation. Suggested features of rapid reaccumulation include lactate dehydrogenase, effusion size, positive cytology, and dyspnoea. Vascular endothelial growth factor (VEGF) correlates with MPE size and treatment response, but its association with reaccumulation rate is unknown. Some anti-VEGF therapies have shown promise in MPE management.

Summary

Further work is needed to validate hypothesised biomarkers of rapid recurrence and to characterise other biomarkers, such as VEGF. The Reaccumulation rate of Malignant Pleural Effusions After Therapeutic Aspiration (REPEAT) study aims to address these gaps in the literature and is currently in recruitment.