bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective masks during the SARS‐CoV‐2 pandemic: Any relationship with temporomandibular disorders and orofacial pain?
Authors: d'Apuzzo Fabrizia , Rotolo Rossana Patricia , Nucci Ludovica , Simeon Vittorio , Minervini Giuseppe , Grassia Vincenzo 
Published: April 2023

AbstractBackgroundWearing protective face masks has been one of the indispensable measures to prevent droplets and aerosol particles transmission during the SARS‐CoV‐2 pandemic.ObjectivesThis observational cross‐sectional survey investigated the different types and modalities of protective mask wearing and the possible association with referred signs of temporomandibular disorders and orofacial pain by respondents.MethodsAn online questionnaire was developed, calibrated and administered anonymously to subjects with an age of ≥18 years. It consisted of different sections: demographics, type and wearing modalities of the protective masks, pain in the preauricular area, noise at the temporomandibular joints and headache. Statistical analysis was performed using statistical software STATA.ResultsThe questionnaire received 665 replies mainly from participants aged between 18 and 30 years (315 males and 350 females). The healthcare professionals were 37% of participants, 21.2% of them were dentists. The Filtering Facepiece 2 or 3 (FFP2/FFP3) mask was used by 334 subjects (50.3%), and 578 (87%) wore the mask with two elastics behind the ears. Pain while wearing the mask was referred by 400 participants, and 36.8% of them referred pain with a consecutive use of more than 4 h (p = .042). 92.2% of participants did not report any preauricular noise. Headache associated with the FFP2/FFP3 was referred by 57.7% of subjects (p = .033).ConclusionThis survey highlighted the increased referred the presence of discomfort in the preauricular area and headache possibly associated with a prolonged use of protective face masks for more than 4 h during the SARS‐CoV‐2 pandemic.
Role of open innovation and patents on strategic decision making
Authors: Patra Soumya P. 
Published: April 2023

AbstractThe fourth industrial revolution, as it is popularly known, is transforming the overall ecosystem of business and is swiftly affecting the structure of organizations with respect to their working strategy. It is leading to enhanced collaboration and cross‐application of center‐specific fundamentals across various industries. As a result, collaboration and cross‐licensing of technologies have become the norm rather than an exception. Open innovation, therefore, plays a critical role in various horizontal applications of industry‐specific concepts. As a result, choices such as “keep or sell” or “make or buy” research and development (R&D) supplies have become extremely critical and significant. Therefore, patent‐based research is required as an enabling tool for assisting research on an open innovation‐based approach. This article projects an in‐depth review of the research articles related to various aspects of open innovation and patents and their overall impact on firm performance. This article also suggests an open innovation model that cumulates the role of patents and institutional participation with a focus on firm performance. The impact of open innovation on firm performance is evaluated with respect to variables on market positioning, R&D capacity building with respect to technology lifecycle, the impact of intellectual property, for instance, the existence of valid patents and know‐how, and the process of acquisition of technologies by such organizations.
Impacts of the Egyptian national screening and treatment programme for viral hepatitis C: A cost‐effectiveness model
Authors: Ezzat Sameera , Gamkrelidze Ivane , Osman Alaa , Gomaa Asmaa , Roushdy Ayat , Esmat Gamal , Razavi Homie , Blach Sarah , Abdel‐Razek Wael , El‐Akel Wafaa , Waked Imam 
Published: April 2023

AbstractBackground & AimsEgypt used to have one of the highest prevalences of HCV infection worldwide. The Egyptian Ministry of Health launched a national campaign for the detection and management of HCV to reduce its burden. This study aims to carry out a cost‐effectiveness analysis to evaluate the costs and benefits of the Egyptian national screening and treatment programme.MethodsA disease burden and economic impact model was populated with the Egyptian national screening and treatment programme data to assess direct medical costs, health effects measured in disability‐adjusted life years and the incremental cost‐effectiveness ratio. The scenario was compared to a historical base case, which assumed that no programme had been conducted.ResultsTotal number of viremic cases is expected to decrease in 2030 by 86% under the national screening and treatment programme, versus by 41% under the historical base case. Annual discounted direct medical costs are expected to decrease from $178 million in 2018 to $81 million by 2030 under the historical base case, while annual direct medical costs are estimated to have peaked in 2019 at $312 million before declining to $55 million by 2030 under the national screening and treatment programme. Under the programme, annual disability‐adjusted life years are expected to decline to 127 647 by 2030, leading to 883 333 cumulative disability‐adjusted life years averted over 2018–2030.ConclusionsThe national screening and treatment programme is highly cost‐effective by the year 2021, cost‐saving by 2029 and expected to save about $35 million in direct costs and $4705 million in indirect costs by 2030.
S‐nitrosylation of ACO homolog 4 improves ethylene synthesis and salt tolerance in tomato
Authors: Liu Minghui , Wei Jin‐Wei , Liu Wei , Gong Biao 
Published: April 2023

Summary

Crop loss due to soil salinization is a global threat to agriculture. Nitric oxide (NO) and ethylene involve in multiple plant tolerance. However, their interaction in salt resistance remains largely elusive.

We tested the mutual induction between NO and ethylene, and then identified an 1‐aminocyclopropane‐1‐carboxylate oxidase homolog 4 (ACOh4) that influences ethylene synthesis and salt tolerance through NO‐mediated S‐nitrosylation.

Both NO and ethylene positively responded to salt stress. Furthermore, NO participated in salt‐induced ethylene production. Salt tolerance evaluation showed that function of NO was abolished by inhibiting ethylene production. Conversely, function of ethylene was little influenced by blocking NO generation. ACO was identified as the target of NO to control ethylene synthesis. In vitro and in vivo results suggested that ACOh4 was S‐nitrosylated at Cys172, resulting in its enzymatic activation. Moreover, ACOh4 was induced by NO through transcriptional manner. Knockdown of ACOh4 abolished NO‐induced ethylene production and salt tolerance. At physiological status, ACOh4 positively regulates the Na+ and H+ efflux, and keeps K+/Na+ homeostasis by promoting salt‐resistive genes' transcripts.

Our findings validate a role of NO‐ethylene module in salt tolerance and uncover a novel mechanism of how NO promoting ethylene synthesis against adversity.
Job Protection and Mortgage Conditions: Evidence from Italian Administrative Data*
Authors: Mistrulli Paolo Emilio , Oliviero Tommaso , Rotondi Zeno , Zazzaro Alberto 
Published: April 2023

AbstractThis paper combines administrative data from the Italian social security administration and proprietary data from a major Italian commercial bank to analyse the impact of job protection legislation on mortgage conditions. An exogenous change in the degree of job protection against individual dismissals of workers with open‐ended contracts is identified by exploiting the labour market reform of 2015, the ‘Jobs Act’, which weakened the employment protection of new hires at medium‐sized and large private firms. We find that the lessening of job security led to lower mortgage amounts and a fall in leveraging capacity, as measured by the loan‐to‐value ratio. The impact of job insecurity is mitigated by the presence of co‐mortgagors; it is aggravated for young and low‐income mortgagors.
The Interval of Two‐Stage Bilateral Total Hip Arthroplasty under Enhanced Recovery Affects Perioperative Complications and Cost of Hospitalization: A Retrospective Study
Authors: Sun Kaibo , Zhou Jinhan , Wu Yuangang , Zeng Yi , Xu Jiawen , Wu Limin , Li Mingyang , Shen Bin 
Published: April 2023

ObjectivesPerioperative enhanced recovery after surgery (ERAS) protocols can improve the quality of healthcare and reduce hospitalization for patients who underwent total hip arthroplasty (THA). The interval of staged bilateral THA under ERAS is still unclear. We attempt to ascertain the optimal interval of staged bilateral THA for reducing the perioperative complications and the cost of hospitalization.MethodsWe retrospectively reviewed patients who received staged bilateral THA under ERAS performed at West China Hospital of Sichuan University from 2018 to 2021. The staged time was divided into two groups using four different cutoff points: (1) ≤3 months versus >3 months, (2) ≤4 months versus >4 months, (3) ≤5 months versus >5 months and (4) ≤6 months versus >6 months. Primary outcomes included the rate of perioperative complications and the cost of hospitalization. The secondary outcomes were the length of hospital stay (LOS), the rates of transfusion and albumin (Alb) administration, hemoglobin (Hb) decrease and serum Alb decrease. The categorical variables were compared using chi‐squared and/or two‐tailed Fisher's exact tests, whereas continuous variables were compared using two‐tailed independent t‐tests, the continuous variables which were asymmetrical distributions used a Kruskal–Wallis test.ResultsWith the application of ERAS, the rate of perioperative complications in the >5 months group was significantly lower than that in the ≤5 months group (13/195 vs. 45/307, p < 0.05). Concerning the cost of hospitalization, the >5 monthly intervals spent significantly less than the ≤5 monthly intervals ($ 8695.91 vs. $ 8919.71, p < 0.05). However, no significant difference was found for secondary outcomes such as the rate of transfusions and Alb administrations or decreases of Hb and Alb in the 5 months threshold.ConclusionsMore than 5 months maybe a reasonable period to perform the first contralateral THA under ERAS regarding the rate of perioperative complications and the cost of hospitalization. However, more high‐quality research will include a larger sample size in the future to validate the appropriate time of staged bilateral THA.
Perioperative gabapentin usage in pediatric patients: A scoping review
Authors: Chen Olivia , Cadwell Joshua B. , Matsoukas Konstantina , Hagen John , Afonso Anoushka M. 
Published: April 2023

AbstractBackgroundThere has been a recent focus among anesthesiologists on reducing the use of perioperative opioids in favor of multimodal analgesic regimens. Gabapentin has played an integral role in this evolution of practice. This comprehensive review assesses the current clinical evidence on the efficacy of perioperative gabapentin regarding postoperative pain and opioid requirements among the pediatric surgery population.Data SourcesPubmed, CINAHL, Embase, Scopus, and Web of Science Review.MethodsThis scoping review of the above databases includes all studies examining the use of gabapentin perioperatively in pediatric patients and its association with postoperative pain intensity and postoperative opioid consumption through July 2021. The inclusion criteria encompassed all studies evaluating gabapentin in the perioperative pediatric population through randomized controlled trials (RCTs) and retrospective studies. Relevant metadata from each study were abstracted and descriptive statistics were used to summarize the results.ResultsFifteen papers met the inclusion criteria for this review, including 11 RCTs and 4 retrospective studies. Sample sizes ranged from 20 to 144 patients. Administered doses varied widely, mainly between 5 and 20 mg/kg. The studies included primarily orthopedic (10) and neck surgery cases (3). Seven papers had gabapentin provided preoperatively only, two postoperative only, and six both pre‐ and postoperatively. Of the studies assessing postoperative pain, 6/11 studies saw a decrease in postoperative pain in at least one period for the gabapentin group. Of the studies considering opioid requirements, 6/10 reported a reduction, 1/10 an increase, and 3/10 no difference in opioid requirements for the gabapentin groups. Yet, most of these pain and opioid requirement findings were only significant at one to two time points in the study follow‐up periods, and the actual decreases had minimal clinical significance.ConclusionsThe current data on perioperative gabapentin in pediatric patients are insufficient to support the routine use of gabapentin in pediatric patients. Additional high‐quality RCTs with more standardized protocols for gabapentin administration and outcome measures are necessary to provide more definitive conclusions.
Adaptive estimation of intensity in a doubly stochastic Poisson process
Authors: Deschatre Thomas 
Published: April 2023

AbstractIn this paper, I consider a doubly stochastic Poisson process with intensity where is a continuous Itô semi‐martingale. Both processes are observed continuously over a fixed period . I propose a local polynomial estimator for the function on a given interval. Next, I propose a method to select the bandwidth in a nonasymptotic framework that leads to an oracle inequality. Considering the asymptotic , and , the accuracy of the proposed estimator over the Hölder class of order is if the degree of the chosen polynomial is greater than and it is optimal in the minimax setting. I apply those results to data on French temperature and electricity spot prices from which I infer the intensity of electricity spot spikes as a function of the temperature.
Hyperbaric treatment of platelets is comparable to cold storage alone over 14 days
Authors: Reddoch‐Cardenas Kristin M. , Pidcoke Heather F. , Ramasubramanian Anand K. , Meledeo M. Adam , Cap Andrew P. 
Published: April 2023

AbstractBackgroundPlatelets stored at room temperature (22–24°C) for transfusion purposes have a shelf life of 5–7 days, or 72 h when stored refrigerated (1–6°C). The limited shelf life of platelet products severely compromises platelet inventory. We hypothesized that cold storage of platelets in 100% plasma using xenon gas under high pressure would extend shelf life to 14 days.Study Design and MethodsDouble apheresis platelet units were collected and split equally between two bags. One unit was placed in a hyperbaric chamber, pressurized to 4 bars with a xenon/oxygen gas mixture, and placed in a refrigerator for 14 days (Xe). The remaining unit was aliquoted into mini‐bags (10 ml) for storage at room temperature (RTP) or in cold (CSP). Samples were assayed on days 5 (RTP) or 14 (Xe and CSP) for count, metabolism, clot strength, platelet aggregation, and activation markers.ResultsThe platelet count in Xe samples was lower than that of RTP but significantly higher than CSP. Despite similar levels of glucose and lactate, the pH of Xe samples was significantly lower than CSP. Glycoprotein expression was better preserved by Xe storage compared to CSP, but no differences in activation were observed. Thromboelastography and aggregometry results were comparable between all groups.DiscussionCold storage of platelets in plasma with hyperbaric xenon provides no significant improvement in platelet function over cold storage alone. The use of a hyperbaric chamber and the slow off‐gassing of Xe‐stored units complicate platelet storage and delivery logistics.
Biomechanical comparison of one pin versus two pin fixation in a canine tibial tuberosity avulsion fracture model
Authors: Welsh Peter J. , Thompson Devin J. , Chen Yi , Smith Lloyd V. , Nylund Adam M. 
Published: April 2023

AbstractObjectiveTo determine whether one larger or two smaller diameter pins used for tibial tuberosity avulsion fracture (TTAF) stabilization provides greater axial tensile strength and stiffness when subjected to monotonic mechanical load to failure in normal skeletally mature canine cadavers.Study designPaired ex vivo biomechanical study.Sample populationEleven pairs of adult cadaveric dog tibias.MethodsTwenty‐two tibias from 11 dogs were collected to model a TTAF. Each limb of a pair was randomly assigned a one or two‐pin fixation. Tibias were subjected to monotonic, axial load to failure. Fixation stiffness, strength, and pin insertion angles were analyzed with parametric testing. Significance was set at p < .05.ResultsThe mean strength of the single‐pin fixation was 426.2 ± 50.5 N compared to two‐pin fixation at 639.2 ± 173.5 N (p = .003). The mean stiffness of the single‐pin fixation was 57.3 ± 18.7 N/mm and the two‐pin fixation was 71.7 ± 20.5 N/mm (p = .029). The normalized ratio between one and two‐pin fixation had a mean stiffness of 68% ± 25.8% and strength of 82.8% ± 24.6%.ConclusionsIn an ex vivo cadaveric TTAF model, vertically aligned two‐pin fixation offers greater strength and stiffness when compared to a single‐pin fixation.Clinical significanceWhen repairing TTAF, surgeons should aim to apply two vertically aligned pins rather than a single pin for greater strength and stiffness.
ENGINEERING PROPERTIES OF LIGHTWEIGHT FOAMED CONCRETE STRENGTHEN WITH FIBREGLASS NETTING
Authors: Othuman Mydin Md Azree 
Published: April 2023

Lightweight foamed concrete (LFC) is widely recognised as a low-density concrete with multiple applications. Yet, since its weight is approximately half that of conventional concrete, its strength should also be lower. Hence, synthetic and natural short fibres were utilised by previous researchers to enhance the performance of LFC. The use of textiles as reinforcing elements has attracted substantial attention in recent years. Consequently, the purpose of this study was to conduct an experimental investigation to determine the engineering properties of LFC reinforced with fibreglass mesh netting. In this study, LFC samples with densities of 550 kg/m3 and 1150 kg/m3 were formulated using a constant cement-to-sand ratio of 1:1.5, and a cement-to-water ratio of 0.45. The LFC specimens were jacketed with 1 layer, 2 layers and 3 layers fibreglass netting. The properties determined were compressive strength, flexural strength, split tensile strength, porosity, water absorption, UPV and drying shrinkage. Accordingly, the results showed that the incorporation of fibreglass netting in LFC helps reduce the absorption of water and the porosity of LFC for all densities. In addition to crack control, fibreglass netting also improves the drying shrinkage, flexural, compressive, tensile strengths and UPV. The optimal engineering properties were achieved with the addition of 3-layer fiberglass netting for 1150 kg/m3 density LFC.
Effect of Rarefaction on Thermal and Chemical Non-Equilibrium for Hypersonic Flow With Different Enthalpy and Catalytic Wall Conditions
Authors: Kumar Shubham , Assam Ashwani 
Published: April 2023

AbstractCompressibility and rarefaction effect plays an essential role in the design and study of objects experiencing hypersonic flows. The presence of chemical and thermal non-equilibrium in hypersonic flows increases the complexity of estimating aerothermodynamic properties, which are essential for developing thermal protection systems and the aerothermodynamic design of hypersonic vehicles. In this study, the hy2Foam solver, developed in an OpenFOAM framework by hyStrath group, is used to understand the effect of Knudsen number (which in turn depends on the altitude) and freestream enthalpy variation on the surface aerothermodynamic properties such as pressure, heat flux, velocity slip, temperature jump, and flow field variables such as species concentration and temperature, in five-species air flow over a cylinder, for both noncatalytic and fully catalytic wall conditions. The novelty of the work lies in reporting the effect of rarefaction on thermal and chemical non-equilibrium (associated with hypersonic flows), and thus on the surface properties under different enthalpy and wall catalytic conditions. It has been shown that the rarefaction effect is more pronounced on the vibrational temperature component and for high enthalpy gas. The surface wall heat flux and the chemical reaction rate among the species decrease with rarefaction. The skin friction coefficient is one of the most sensitive properties, while the pressure coefficient has been the least susceptible to non-equilibrium effects. The stagnation points heat flux at different Knudsen numbers shows good agreement with the existing correlation in literature for both low and high enthalpy flows, which further establishes the validity of the study done in this work.
Resistance Training Behavior Is Enhanced With Digital Behavior Change Coaching: A Randomized Controlled Trial With Novice Adults
Authors: Kompf Justin , Whiteley Jessica , Wright Julie , Brenner Philip , Camhi Sarah 
Published: April 2023

Background: Approximately a third of US adults meet the physical activity guidelines of engaging in resistance training 2 times per week, yet few studies have examined how to increase participation rates. The present randomized control trial compared a remotely delivered coaching intervention with an education only control group. Methods: Eligible participants completed 2 remotely delivered Zoom-based personal training sessions during a 1-week run-in period. Participants randomized to the intervention group received synchronous weekly behavioral video coaching sessions over Zoom, whereas the control group received no further contact. Days of resistance training completed were assessed at baseline (pre), 4 weeks (post), and 8 weeks (follow-up). Linear mixed models were used to examine group differences at each time point and within-group differences over time. Results: There were significant between-group differences favoring the intervention, at posttest for both the previous week (b = 0.71, SE = 0.23; P = .002) and the previous 4 weeks (b = 2.54, SE = 0.87; P = .003) but not at the follow-up period for either the last week (b = 0.15, SE = 0.23; P = .520) or the last 4 weeks (b = 0.68, SE = 0.88; P = .443). Conclusion: The present study showed that by providing participants with equipment, skill, and in the case of the intervention group, a remote coaching intervention, resistance training participation increased.