bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of Emotion Regulation Based on Yogic Personality Using Implicit, Explicit, and Eye Tracking Techniques
Authors: Kumar R. Senthil , Britto John , Ilavarasu Judu , Rajesh S. K. 
Published: April 2023

Context:Emotion regulation (ER) is vital for well-being. Yogic personality traits,gunas, influence the expression of ER.Aims:To investigate the expression of ER based on guna-related personality traits employing explicit, implicit, and objective eye-tracking techniques.Settings and Design:Quota sampling was used, with a cross-sectional design with three groups, sattva, rajas, and tamas. Three hundred and ninety-four female students were screened and finally, 30 fromsattva, 34 fromrajas, and 36 fromtamaswere analyzed.Methods:Participants were given State and Trait Mindfulness Scales, Gita Inventory, Social Desirability Scale, state-trait anxiety inventory, Adult Attachment Scale, and Emotional Regulation Questionnaire. ER-Implicit Association Test (ER-IAT) and Eye Tracker were also used to evaluate the participants.Statistical Analysis Used:One-way repeated-measures analysis of variance was used to examine differences betweensattva,rajas, andtamas.Results:Sattvagroup adopted a higher level of regulation strategy, ER-IAT scores were positive forsattva, negative for rajas and tamas. Mindfulness was highest and anxiety was least insattva. In the eye tracker, within the non-emotional areas of interest (eAOI) regions of pleasant condition, and eAOI regions of unpleasant condition,sattvagroup had considerably higher dwell time. Pupil dilation was lowest in sattva for all the conditions, both within and outside eAOIs.Conclusions:Sattvagunawas found to foster healthy ER, and other psychological attributes. Conscious cultivation of sattva is needed for healthy emotional life.
Surya Namaskar
Authors: Bandyopadhyay Abhishek , Halder Kaushik , Pathak Anjana , Kumar Bhuvnesh , Saha Mantu 
Published: April 2023

Context:
“Surya Namaskar” (SN) may be used as a need-based short-duration aerobic activity in a confined space to establish as a substitute of an equivalent routine physical training in challenging stressful conditions.

Materials and Methods:
Noninvasive oxygen-kinetics metabolic responses between SN and endurance work on bicycle ergometry (BE) were compared across different phases of maximal oxygen uptake percentage (%VO2 max). SN, comprising three complete rounds per min (36 beats/min of a metronome; SN consists of 12 poses per round), was performed rhythmically and continuously for 5 min to simulate an incremental BE test (25 watts/2 min at 60 rpm).

Results:
SN results in a significant (P < 0.05) greater increase of arteriovenous oxygen difference at 71%–80% VO2 max while keeping a low respiratory exchange ratio (P < 0.01 and 0.001) at 41%–80% VO2 max exercising state.

Conclusions:
SN could be an ideal form of aerobic exercise instead of BE.
Effect of Yoga on Stress, Anxiety, Depression, and Spinal Mobility in Computer Users with Chronic Low Back Pain
Authors: Singphow Chametcha , Purohit SatyaPrakash , Tekur Padmini , Bista Suman , Panigrahy Surya Narayan , Raghuram Nagarathna , Nagendra Hongasandra Ramarao 
Published: April 2023

Background:
Office workers who need to use a computer while maintaining a static position for prolonged periods have more chance of having low back pain (LBP).

Objective:
The objective of the study is to investigate the effect of yoga on stress, anxiety, depression, and spinal mobility in computer users with chronic LBP (CLBP).

Materials and Methods:
In this randomized control trial, eighty computer users (42.6 ± 8.45 years of age; suffering from CLBP since 5.20 ± 3.01 years; 51 males and 29 females) who use a computer for their professional work, recruited from Bengaluru, India, were randomized into two groups: yoga group (n = 40) and physical exercise group (n = 40). The yoga group practiced an integrated module comprising yoga postures and mindfulness meditation, and the physical exercise group practiced physical exercise designed for LBP (1 h/day, 3 days/week for 16 weeks). Assessments of dial-type goniometer and Depression Anxiety Stress Scale-42 were performed at baseline, after 8 weeks, and after 16 weeks.

Results:
Stress, anxiety, and depression scores were significantly lower in the yoga group as compared to the physical exercise group at 16 weeks (P < 0.001), whereas spinal flexion (P < 0.001), spinal extension (P < 0.001), right lateral flexion (P = 0.001), and left lateral flexion (P = 0.007) scores were significantly higher in the yoga group as compared to the physical exercise group at 16 weeks.

Conclusion:
Yoga is more effective in reducing stress, anxiety, and depression and improving spinal mobility in computer users with CLBP than physical exercise designed for LBP.
Uncommon Foot Pain
Authors: Sales Kelsen dos Santos , de Matos Mota Anacélia Gomes , Gusmão Camilla Teixeira Pinheiro , Ribeiro Junior Howard Lopes 
Published: April 2023

ABSTRACT
Cutaneous pili migrans (CPM) is an uncommon condition in which a hair fragment penetrates the skin and produces a creeping lesion similarly of cutaneous larva migrans associated with local pain. There are few reports of CPM in the literature, and none visually describes the migration of the hair shaft in the epidermis associated with pain. Herein, we showed the first report describing a case of an in situ sequential migration of CPM in an adult patient.
Efficacy of Low-Level Laser Therapy in Androgenetic Alopecia – A Randomized Controlled Trial
Authors: Sondagar Dharm Mansukh , Mehta Hita H. , Agharia Rashmiben Sabbirali , Jhavar Milan K. 
Published: April 2023

ABSTRACT

Background:
Androgenetic alopecia (AGA) is caused by the susceptibility of hair follicles to androgenic miniaturization, which leads to hair loss. The most common modalities for the treatment of AGA include the use of topical minoxidil and oral finasteride. Low-level laser therapy (LLLT) is a newer modality of treatment for AGA. We tried to evaluate the added benefit of LLLT in AGA compared with topical minoxidil 5% alone.

Aim:
The aim of this study was to compare the efficacy of LLLT combined with topical 5% minoxidil in AGA versus topical 5% minoxidil used alone.

Materials and Methods:
After ethics committee approval, 54 patients of AGA were randomly divided into two groups. Group A participants received LLLT therapy twice a week plus topical 5% minoxidil and Group B participants received only minoxidil 5% solution. Both the groups were followed up for 16 weeks and evaluated with gross photographs, TrichoScan analysis, and dermoscopy to look for any improvement in hair density.

Results:
After 16 weeks, improvement in hair density of 14.78% ± 10.93% in Group A was recorded compared to 11.43% ± 6.43% in Group B. However, while comparing both means, P value was 0.45 which was not significant. The physician global assessment and patient satisfaction score revealed no significant difference between both the groups.

Conclusion:
Although LLLT appears to be safe and effective in the treatment of male pattern hair loss, we did not observe any significant difference in terms of improvement in hair density between both the groups.
To Assess the Functional and Radiological Outcomes of Intra-Articular Fractures of Distal end Radius by Open Reduction and Internal Fixation with Locking Distal Radius Volar Plate
Authors: Verma Ashutosh , Saroj Atul Kumar , Kumar Ankit , Patel Upendra , Prajwal M. C. 
Published: April 2023

Background:
Intra-articular fracture distal radius is a common fracture and remains one of the most challenging fractures to treat without any complications. In unstable intra-articular fractures, re-establishment of intra-articular integrity of the wrist and maintaining the radiological parameters are often not possible with close methods. In such cases where an open reduction is required, various surgical methods and fixation materials can be used.

Materials and Methods:
A total of 35 patients with clinico-radiological diagnoses of intra-articular fractures of the distal end of the radius participated in the study. All the patients were followed up for a minimum of 6 months after the procedure, and the observations thus made were tabulated.

Results:
Functional outcome in terms of Quick DASH was excellent to good in 88.6% patients on the basis of Quick Dash Score Grading with no significant loss of radiographic reduction and a better range of movements throughout the follow-up period.

Conclusion:
Volar plate fixation is viable and one of the most favorable means of management with maximum anatomical restoration and functional gain.
Is Tension Band Wiring (Osteosynthesis) with Three Kirschner Wires Provide Better Outcome as Compared with Two Kirschner Wires in Patella Fracture
Authors: Kumar Sachin , Singh Mohit , Kumar Satish , Khare Rahul , Yadav Ajay Kumar , Kumar Deepak 
Published: April 2023

Background:
Fractures of the patella constitute approximately 1% of all skeletal injuries, resulting from either direct or indirect trauma. Many forms of internal fixation for patellar fractures have been described in the literature but perfect anatomical reduction during surgery has an excellent outcome irrespective of the method of fixation used. The conventional method of patellar tension band wiring (TBW) is being done always with the help of two parallel Kirschner wires (K-wires).

Objectives:
Here in our prospective study, we intended to see whether the use of three parallel K-wires in comparison to the conventional one results in superior functional outcomes.

Materials and Methods:
A prospective cohort study was carried out in New Delhi from November 2016 to November 2019 in a total of 44 patients with patellar fractures operated by TBW with 22 patients in two parallel K-wires and three parallel K-wires groups, respectively. Patients were followed up postoperatively for 1 year and assessed by Lysholm knee score (LKS), pain status, working status, and other variables Normality of data was tested by Kolmogorov–Smirnov test and paired t test/Wilcoxon rank-sum test.

Results:
The total mean age was 40.27 years (41.86 in 2K-wire and 38.68 in 3K-wire) in this study. LKS (0.00 in both groups on first day; 99.23 and 99.45 after 1 year in 2K-wire and 3K-wire groups, respectively, pain status (was 5.0 in both groups on the first day and 1.0 after 6 month), and working status (was 5.0 in both groups on the first day and 1.09 after 1 year), were not significantly different throughout the mean to follow up periods for both groups (P > 0.05).

Conclusions:
No significant difference was observed between patellar TBW in 3K-wire and 2K-wire groups.
Tubercular Flexor Tenosynovitis with Carpal Tunnel Syndrome Mimicking as Compound Palmar Ganglion
Authors: Mahapatra Swagat , Mishra Madhusudan , Patel Jaydeep , Mishra Prakhar , Singh Devta 
Published: April 2023

Introduction:
Tubercular flexor tenosynovitis is an infrequent condition, which has a mixed clinical picture, but with careful examination and investigation, it should be diagnosed earlier before the involvement of underlying bones and nerves.

Case Report:
We present a case of a 69-year-old man who came with complaints of progressive swelling over the palm and forearm. He was presented as compound palmar ganglion but finally diagnosed as a case of chronic flexor tenosynovitis with association of carpal tunnel syndrome of tubercular origin without involvement of the underlying bones and was treated by complete excision and antitubercular therapy.

Conclusion:
Tuberculous flexor tenosynovitis is a condition that can be managed by excision and antitubercular therapy. However, it presents as a challenge to the surgeons when the presentation is very late. Hence, early identification and treatment are the main goals of this article.
Extracorporeal irradiation in malignant bone tumors: Single institution experience and review of literature
Authors: Agarwal Shruti , Rathi Arun Kumar , Singh Kishore , Melgandi Wineeta , Ansari Faiz Akram , Arora Savita 
Published: April 2023

ABSTRACT
In the last couple of decades, the management of malignant bone tumor (MBT) has seen a sea change. With the advent in surgical technics, radiation therapy, and chemotherapy, it has moved from disabling amputation to limb salvage surgery. Extracorporeal irradiation (ECI) and re-implantation of resected bone is a useful method of limb salvage of MBTs. In our study, we analyzed and presented the results of 8 cases of MBTs treated with this modality. Between 2014 and 2017, 8 patients with primary MBT were enrolled for ECI technique who are meeting the eligibility criteria. Before taking the patient for ECI treatment, a multispecialty tumor board discussion was done for each patient. All of them received neo-adjuvant and adjuvant chemotherapy except the patients with histology of giant cell tumor. Following neoadjuvant chemotherapy bone excision surgery was performed, and the resected bone was taken for ECI with the dose of 50 Gray in a single fraction. After ECI, bone segment was re-implanted at osteotomy site in the same setting. After completion of adjuvant chemotherapy, the patients were then followed up for any sequelae, local and systemic control, ambulation, and functional outcome. Out of 8 patients, there were 5 males and 3 females with mean age of 22 (range 13–36). The involved bone was the tibia in 6 patients, ischium in 1 patient, and femur in 1 patient. Histopathologically, the malignancies included 3 osteosarcoma, 3 Giant cell tumor, 1 Ewing’s sarcoma and 1 chondrosarcoma. At median follow-up of 12 months (range 6–26 months), local control rate was 87.5% and systemic control rate was 75%. Perioperative ECI and re-implantation is a useful, convenient, and inexpensive technique. The overall treatment time is reduced. The patient’s own bone fits perfectly to the resection site with reduced risk of graft site infection. The risk of local recurrence due to tumor re-implantation is negligible with tumoricidal radiation doses of ECI, and it is usually associated with manageable sequelae. Recurrence rates are acceptable and salvageable with surgery.
An adding up of an exceptionally rare case report: Primary Squamous cell carcinoma of Jejunum from North India
Authors: Singh Divya , Kumar Arvind , Gowda Vinay , Sahai Rishabh , Kumar Sudhir , Kishore Sanjeev 
Published: April 2023

ABSTRACT
Squamous cell carcinoma (SCC) of lower gastrointestinal tract is a rare tumor and duodenum is the most common site of involvement. In addition, involvement of jejunum by SCC is further exceptionally rare, and only nominal cases are present world literature. Being a very infrequent finding, a clinician and a pathologist must be aware of this rare entity. Diagnosis requires histopathology along with clinico-radiological correlation since merely histopathology is unable to differentiate between primary and metastatic tumor. Treatment modality is totally different in primary and secondary tumor of lower gastrointestinal tract. Being an extremely rare case of primary SCC of jejunum in an elderly female makes it eligible to be acknowledged at the global platform of medical literature.
Evaluation of quality of life in posttreatment upper aerodigestive tract cancer patients
Authors: Sujith Akshay , Sharma Neeta , Guruprasad R. , Gupta Manish 
Published: April 2023

ABSTRACT

Background:
Cancers of the upper aerodigestive tract constitute approximately 4% of all malignancies. Posttreatment cancer patient faces serious adversities that affect the quality of life. Out of the various scales available to measure the quality of life, we chose the quality of life-oral cancer (QOL-OC), which was developed and evaluated by Nie et al. in 2018.

Aims and Objectives:
The aim of our study was to assess the quality of life in posttreatment upper aerodigestive tract cancer patients in a tertiary care center and also to check the reliability and validity of the questionnaire QOL-OC.

Methodology:
We communicated with 89 patients who were pathologically tested positive for upper aero digestive tract cancer from January 2019 to December 2019.

Results:
The most prevalent adversity was found to be altered salivary flow, followed by diet and difficulty while eating. The QOL-OC was found to be a highly valid and reliable questionnaire.

Conclusion:
The study points out regarding the prevalence of various adversities in post treatment cancer patients, a discussion has also been made suggesting the importance of multidisciplinary approach that should be provided in such patients. Finally, the study also concludes regarding the generalizability of the questionnaire QOL-OC.
Anticancer potential of Nymphaea nouchali Brum flowers against Ehrlich ascites carcinoma cell lines
Authors: Nagavani V. , Raghavarao T. 
Published: April 2023

ABSTRACT

Background:

Nymphaea nouchali Brum is exotic and medicinal plant in India.

Aim of the Study:
The main of this study is to evaluate the anticancer properties of Nymphaea nouchali Brum flowers against Ehrlich ascites carcinoma (EAC)-induced Swiss albino mice.

Materials and Methods:
The anticancer properties of Nymphaea nouchali Brum dry and fresh methanol extracts was investigated using EAC in Swiss albino mice. After inoculation of EAC cells into mice, treatment with NNDM flower extract (200 and 400 mg/kg) and standard drug 5-Fluorouracil (20 mg/kg) was continued for 9 days. The evaluation of the effect of drug response was made by the study of tumor growth response including increase in lifespan, the study of hematological parameters, biochemical estimations, and antioxidant assay of liver tissue compared to EAC control. The viability of cancer cell lines (such as HeLa, MCF-7, and MDA-MB 231 cells) was evaluated by 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay.

Results:
Therefore, from the results of the present study, it can be concluded that NNDM exhibited significant antitumor activity against EAC in Swiss albino mice. The effect of NNDM on viability of cancer cell lines (such as HeLa, MCF-7, and MDA-MB 231 cells) was evaluated by MTT assay, apoptosis in HeLa cell lines was evaluated by DNA laddering assay, HeLa cells treated with NNDM exhibited a characteristic “ladder” pattern after separation of the fragments by agarose gel electrophoresis and subsequent visualization, by ethidium bromide staining. NNDM exhibited a significant effect on cell viability.

Conclusions:
Based on results, it was concluded that NNDM exhibited cytotoxic effect on cancer cells and, from DNA laddering assay, it can be concluded that NNDM-induced apoptosis in EAC cells.
To evaluate eosinophilia (tissue eosinophilia, blood eosinophilia and tissue eosinophilia/blood eosinophilia ratio) in increasing grades/ severity of oral neoplastic lesions
Authors: Kaur Navpreet , Zaheer Sufian , Sangwan Shruti , Ranga Sunil 
Published: April 2023

ABSTRACT
Oral squamous cell carcinoma (OSCC) is the most common cause of morbidity and mortality in India. Buccal mucosa is the most common site because of tobacco quid. Several parameters for the assessment of OSCC have been studied like lymph node metastasis, tumor stage, grade, and perineural invasion. Tumor-associated tissue eosinophilia is another parameter, on which several studies have been done because of its favorable and unfavorable prognosis. The aim of our study is to study quantitative and qualitative eosinophilia in premalignant and malignant lesions of squamous origin in oral cavity with respect to tumor-associated blood eosinophilia. A retrospective study was done at Tertiary care hospital between January 2016 and December 2016. A total of 150 cases of premalignant (oral leukoplakia and dysplasia) and malignant oral squamous cell carcinoma (of various grades) along with blood pictures were evaluated.
A study on histological grading systems of oral squamous cell carcinoma and comparison of their efficacy in determining the nature (clinical and histopathological) and prognosis of oral squamous cell carcinoma
Authors: Pandya Jay A. , Natarajan Srikant 
Published: April 2023

Abstract

Purpose:
Tumour-Node-Metastasis (TNM) staging has been widely used for treatment planning and prognostication of oral cancers; however, TNM staging system alone is insufficient for optimal prognostication. A combined assessment of clinical staging and cytomorphology might serve as a more specific measure for prognostication. The present study attempted to compare the efficacy of histologic grading systems (Jakobbson et al., Anneroth et al. and Bryne et al.) of malignancy in determining the nature and prognosis of oral squamous cell carcinoma (OSCC). Tumour protein (TP53) immunohistochemical marker was used to determine the aggressiveness of OSCC.

Materials and Methods:
Tissue sections from 24 biopsy-proven cases of OSCC were stained with anti-TP53 antibody. Hundred cells in each case were counted and tabulated. Cases were graded using three histopathological grading systems. Findings were compared and correlated with TP53 immunopositivity and clinical parameters.

Results:
Positive correlation was observed between TP53 immunostaining and grading scores of each system. Highest correlation was observed with Jakobbson et al. grading system (r2 value = 0.91, P < 0.001). Significant results were observed on comparing grades of Jakobsson et al., Anneroth et al. and Bryne et al. grading system with segregated groups of TP53 immunopositive cases (P = 0.004, P = 0.003, P = 0.001, respectively). No significant results were observed on comparing grades of histopathological systems with clinical parameters.

Conclusion:
Both, clinical and histopathological grading systems, with immunohistochemistry, should be taken into account during the assessment of OSCC, for treatment planning and better prediction of tumour prognosis.
Multidrug resistance protein 1 silencing in osteosarcoma and chondrosarcoma cell lines
Authors: Freund Sarah S. , Bendtsen Michael M. , Safwat Akmal , Joergensen Peter H. 
Published: April 2023

ABSTRACT

Background:
The poor response of metastatic osteo- and chondrosarcomas to chemotherapy could be the result of multidrug resistance (MDR), which may be overcome through the use of small interfering RNA (siRNA). However, several methodologic questions remain unresolved.

Aims:
To test the toxicity of three commonly used siRNA transfection reagents and apply the least toxic reagent to investigate the siRNA-induced MDR1 mRNA knockdown.

Methods:
The toxicity of TransIT-TKO, Lipofectamine 2000, and X-tremeGENE siRNA transfection reagents was investigated on osteosarcoma (MG-63) and chondrosarcoma (SW1353) cell lines. The toxicity was measured at 4 and 24 hours using a MTT toxicity assay. The least toxic transfection reagent was applied to investigate the siRNA-induced MDR1 mRNA knockdown effect using qRT-PCR. Furthermore, five housekeeping genes were assessed in the BestKeeper software to obtain mRNA expression normalization.

Results:
Lipofectamine 2000 was the least toxic transfection reagent, reducing the cell viability only in chondrosarcoma 24 hours following exposure to the highest dose. In contrast, TransIT-TKO and X-tremeGENE transfection reagents displayed a significant reduction in cell viability in both chondrosarcoma after 4 hours and in osteosarcoma after 24 hours. Significant MDR1 mRNA silencing of over 80% was achieved in osteo- and chondrosarcoma using Lipofectamine at a final siRNA concentration of 25 nM. No significant dose response was observed in knockdown efficiency in either Lipofectamine or siRNA concentration.

Conclusion:
Lipofectamine 2000 was the least toxic transfection reagent in osteo- and chondrosarcoma. Successful siRNA-induced MDR1 mRNA silencing of over 80% was achieved.