bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement of Employee Performance through Leadership Style, Readiness to Change and Competence with Work Discipline as a Moderating Variable in Indonesian Islamic Banks
Authors: Nurmasari Vivit , Abadiyah Rifdah 
Published: January 2023

The purpose of this study was to determine the improvement of employee performance through leadership style, readiness to change and competence with work discipline as a moderating variable at Bank Syariah Indonesia in Mojokerto. This research is a descriptive study using quantitative methods. The technique for obtaining sampling is using the saturation sampling technique where the total population can be used as a sample, for the number of samples in this study as many as 100 respondents. In testing the data in this study using multiple linear regression techniques with IBM SPSS Statistic software version 2. The results of this study prove that the variables of leadership style, readiness to change and competence can improve employee performance with work discipline as a moderating variable in BSI Mojokerto employees.
Analysis of the Family Hope Program
Authors: Arthamevia Novy , Sukmana Hendra 
Published: January 2023

The purpose of this study was to describe and analyze the family of hope program along with the obstacles in the family of hope program in Sidoarjo Regency. This research is based on the problem of assistants who carry out socialization only once every three months and there are still many PKH recipients who do not understand their rights and obligations. The research method used is qualitative research. The data collection technique is by means of in-depth interviews, observations and relevant literature studies with one key informant, namely the Village PKH assistant and four supporting informants including the District PKH coordinator, village secretary, and PKH assistance recipient communities. The analysis technique in this study uses a qualitative type that refers to the theory of Miles and Huberman. The results showed that the analysis of the family of hope program in Sidoarjo, namely, first, the achievement of goals. The achievement measure is said to have not been achieved because the targets for accepting PKH members are still not on target and the process of managing the aid index for PKH recipients is still not right. The second is integration, the size of integration is said to be not right because there has been no delivery of skills for PKH members in socializing with PKH facilitators. Third, adaptation, PKH facilitators are quite good and can adapt to PKH members and their environment.
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O uso de mapas táteis no estágio curricular supervisionado em Geografia
Authors: Carneiro José , Silva Dirceu , Régis Tamara , Nunes Ana 
Published: January 2023

O trabalho propõe apresentar as experiências vivenciadas a partir da utilização de mapas táteis como material pedagógico para subsidiar as atividades desenvolvidas no Estágio Supervisionado em Geografia, com uma turma do 3° ano do Ensino Médio do Colégio de Aplicação, da Universidade Federal de Santa Catarina – UFSC no semestre 2022.01. Como metodologia foi realizada uma pesquisa bibliográfica para suporte teórico, além de reflexões empíricas a partir das vivências do Estágio Supervisionado I, amparados no diário de campo da disciplina. No curso de Geografia, da Universidade do Estado de Santa Catarina - UDESC, as disciplinas de Estágio Curricular Supervisionado em Geografia I e II proporcionam ao licenciando uma experiência de aprofundamento e consolidação da formação, desde o processo de observação até a etapa de intervenção na escola. Nestas disciplinas, o estagiário elabora planos de aula e media os processos de ensino-aprendizagem de conteúdos curriculares utilizando recursos didáticos direcionados a contemplar os objetivos de aprendizagem. A experiência do Estágio trazida à reflexão, teve como objetivo as apresentar e discutir as três principais regionalizações do Brasil: as cinco Macrorregiões propostas pelo Instituto Brasileiro de Geografia e Estatística – IBGE, os Três Complexos Regionais e Os Quatro Brasis empregando como recursos didáticos mapas táteis. Ficou evidente, com o uso dos mapas táteis para cada regionalização, a sensibilização dos alunos, na percepção e identificação de diferenças de texturas, alturas, formas e outros símbolos presentes no mapa. Constata-se assim que os mapas táteis são recursos com potencial para dinamizar os processos de ensino-aprendizagem e permitindo o acesso às informações gráfico-visuais e a interação entre os alunos com e sem restrições visuais.
POTENSI DAN STATUS KERUSAKAN TANAH UNTUK PRODUKSI BIOMASSA DI KABUPATEN KUTAI TIMUR (Studi Kasus Kecamatan Long Masangat, Batu Ampar dan Rantau Pulung)
Authors: Edwin Muli , Suptrapti Harmi , Sulistyorini Iin Sumbada , Aliri Aliri 
Published: January 2023

Soil degradation to support the growth and development of plants and produce goods and services has become a global concern. To support government programs and efforts to improve land, the role and cooperation of researchers with local governments should be increased to multiply, and information related to the potential of soil degradation can be used as supporting data for development planning in an area. The potential and status of soil degradation in the region of East Kutai Regency, are still relatively low. But it has a high potential for damage because land use more increasing for various purposes. Soils in East Kalimantan is dominated by old soil, such as Podsolic or Ultisols, easily damaged if utilized without regard to principles of conservation. Especially for soil in Rantau Pulung there is a parameter with exceeded status of standard quality, i.e. permeability; then in Batu Ampar found four parameters, namely permeability, the composition of soil fraction, bulk density and soil pH, next to Long Masangat founded two parameters, namely bulk density and permeability. The more of limiting factors, then in the land use should also apply and demand high conservation treatment to maintain the land or soil quality.
PENGARUH PRAKTIK PERTANIAN ORGANIK DAN SEMI ORGANIK TERHADAP BEBERAPA SIFAT TANAH DI LERENG SELATAN GUNUNG MERAPI
Authors: Pratama Amsyah , Afany Miseri Roeslan , Kundarto Muhamad 
Published: January 2023

Volcanic activity provides fertility for the land on the slopes of Merapi. The material from the eruption of Merapi contains many nutrients. The fertility of the Merapi area is used by the people on the slopes of Merapi to grow vegetable and fruit crops. This study aimed to determine the influence of organic and semi-organic farming practices on several soil properties on the southern slopes of Mount Merapi. This research used a survey method. Research locations on organic farming practices in Tani Organik Merapi (TOM), semi-organic farming practices 1 in Indmira and semi-organic farming practices 2 at UPTD BP3MBTP Ngipiksari. Determination of sample points was carried out purposively based on their agricultural practices. Sample points in organic farming practices, semi-organic 1 and 2 as many as 9 sampling points. After that, the physical, chemical, and biological properties of the soils were analyzed ina laboratory. The results of this study showed that organic farming practices could increase soil pH, caciton exchange capacity (CEC) and the number of bacteria.
The portuguese public procurement system as a strategic instrument of public management
Authors: Da Silva Romão Ana Lúcia , Ventura Ferreira Ana Paula 
Published: January 2023

This research aims to evaluate the National Public Procurement System (NPPS) as a strategic instrument of public management, in Portugal. The creation of NPPS, in 2007, followed the European Union model for public procurement, based on criteria of economy, efficiency, and effectiveness that leads to greater transparency and accountability and reflects public value. This experiment analysis which are the weakest and the strongest dimensions of the NPPS and to what extent does the performance of the NPPS fit as a strategic instrument of public management. A research survey, based on the conceptual model developed by Essig et al. (2010) and later applied by Thi et al. (2012), adapted to Portuguese context, was applied to 1,500 entities linked to the NPPS. The sample size of 101 valid questionnaires corresponds to an effective response rate of 5.6%. The data analysis used exploratory factor analysis to validate the distribution of the variables and performed a principal component analysis with varimax rotation. The research concluded that NPPS has, in general, a low level of performance, despite the positive contribution of the “Information and control” and “Electronic platforms” factors in process management. These results corroborate the need for a realignment of the public procurement strategy in Portugal.
An impact of CMV and HHV-6 reactivation on the course of early period after hematopoietic stem cell transplantation in patients with hematologic malignancies
Authors: Antonova T. V. , Nozhkin M. S. , Pobegalova О. Е. , Gorchakova О. V. , Sabadash N. V. , Lioznov D. A. 
Published: January 2023

Objective. To assess the impact of CMV and HHV-6 reactivation on the course of early post-transplant period in patients with hematologic malignancies. Materials. Retrospective analysis of medical records of 339 patients with hematologic malignancies who received hematopoietic stem cell transplantation (HSCT) was performed, and markers of CMV and HHV-6 infections were detected (specific IgG, EIA). Blood and other materials from HSCT recipients were tested (PCR) for viral DNA in early post-transplant period (up to Day 100). Results. Reactivation of viral infections after HSCT was discovered in 177 patients (52,2 %): CMV-infection was detected in 23 %, HHV-6 in 17,4 %, CMV+HHV-6 in 11,6 % of HSCT recipients. CMV DNA was predominantly identified in blood, while HHV-6 DNA was more frequently discovered in GIT mucosa and bone marrow. 40 % of 99 patients with HHV-6 reactivation had concomitant CMV+HHV-6 reactivation. In this group, the clinical manifestation of infections was registered significantly more frequently. Febrile neutropenia was more frequent in HSCT recipients with CMV reactivation, sepsis and graft hypofunction were diagnosed more frequently in presence of HHV-6 and predominantly HHV-6+CMV infections. The direct correlation (using Spearman’s method) between CMV and HHV-6 reactivation and terms of leukopoiesis recovery, engraftment terms, and transplant hypofunction was revealed. An impact of herpetic infections reactivation on the graft hypofunction and late recovery of leukopoiesis was confirmed using the logistic regression; its impact on the chimerism was revealed. In 72 % of cases, the graft failure in early post-transplant period occurred in patients with herpetic infections reactivation. Conclusion. HHV-6 and CMV reactivation in the early period after HSCT correlates with terms of leukopoiesis recovery, contributes to development of complications, and is an additional factor aggravating the course of the post-transplant period.
Сost-effectiveness of pentavalent rotavirus vaccination in the Russian Federation
Authors: Rudakova A. V. , Kharit S. M. , Rychkova S. V. , Lobzin Yu. V. 
Published: January 2023

One of the main causes of acute gastroenteritis in children under 5 years of age is rotavirus infection (RVI). Vaccines against RVI significantly reduce the incidence. Aim. To evaluate the cost-effectiveness of mass vaccination of children with a 5-valent RVI vaccine in the Russian Federation. Materials and methods. The assessment was carried out using modeling based on published data on the effectiveness of the vaccine and epidemiological indicators in the Russian Federation. The analysis was carried out from the perspective of the health care system and society as a whole with a 5-year horizon. The cost of RVI therapy corresponded to the compulsory health insurance tariffs for St. Petersburg for 2022, the price of 1 dose of the vaccine was the registered price, including VAT. Costs and life expectancy, taking into account quality, were discounted at 3.5 % per year. Results. Given the assumptions made, routine vaccination will prevent an average of 468,637 cases of RVI over 5 years. Avoided direct medical costs, i. e. RVI treatment costs will amount to 53,4 %, and lost income due to temporary disability – 46,6 % of the total avoided costs. At the same time, the volume of avoided costs is 61,4 % due to a decrease in morbidity in the vaccinated population, and 38.6 % due to the development of a indirect effect. The predicted avoided costs per 1 vaccinated person is 2,975 thousand rubles. From a societal perspective, the cost-effectiveness of the Rota-V-Aid vaccine will be 364,813 thousand rubles / QALY (quality-adjusted life year), and from a healthcare perspective – 1726,399 thousand rubles / QALY. Thus, in both cases, the cost-effectiveness of RVI vaccination will not exceed the generally accepted threshold of willingness to pay, equal to three times the gross domestic product per capita in the Russian Federation (according to data for 2021 – ~2,7 million rubles). The predicted cost-effectiveness of selective vaccination is significantly lower than that of mass vaccination. Conclusions. Mass vaccination of children with a 5-valent vaccine against RVI will not only reduce the incidence in the Russian Federation, but, taking into account the assumptions made, can also be considered as a cost-effective intervention.
Digital transformation and corporate cash holdings in China's A-share listed companies
Authors: Sun Changling , Lin Ziang , Vochozka Marek , Vincúrová Zuzana 
Published: January 2023

Research background: In the digital era, digital transformation has become a strategic imperative for leadership agenda. Many firms have accelerated their pace in digital transformation to improve their performance and competitiveness. Despite increasing attention in the literature on the role of digital transformation in firms? operations, understanding the effect of digital transformation on corporate finance remains limited. This study focuses on cash holdings, which are essential for firms to survive and thrive.
Purpose of the article: The aim of this paper is to examine the critical role of digital transformation on the cash holdings of listed firms in China and provide micro evidence regarding the economic consequences of the digital economy from firm level. This study also aims to deepen our understanding of the influence of digital transformation on firms? operation and financial policy. Additionally, this paper attempts to provide relevant guidance for implementing policies to promote digital transformation and devise corresponding cash holding strategies.
Methods: The text analysis method is used to measure the degree of digital transformation of China?s A-share listed companies. The sample covers 19,337 observations from 2007?2020. A multiple regression model with firm and year fixed effect is developed to investigate the relationship between digital transformation and corporate cash holdings. In the robustness test, this paper substitutes the independent and dependent variables, and adopts instrumental variable estimation method. In the mechanism test, this paper uses the sub-sample regression method in the mechanism test.
Findings & value added: This study reveals that digital transformation can significantly reduce corporate cash holdings by alleviating the precautionary motive, agency motive and transaction motive of cash holdings. Further analysis shows that the negative effect of digital transformation on cash holdings is more profound in high-tech firms and non-state-owned enterprises. The methodology applied in this paper can be used in other economic research of firms. This study provides insights into the effects of digital transformation on corporate financial policy. This provides a solution for reducing firms? cash holdings. This study also deepens the understanding of digital transformation from a corporate perspective.
New therapeutic strategies based on molecularly targeted therapy in glioblastoma – a case report and review of the literature
Authors: Szklener Katarzyna , Rodzajewska Anna , Kurylo Weronika , Mandziuk Slawomir 
Published: January 2023

Abstract
Glioblastomas are the most common and most lethal forms of malignant primary brain tumor. We present a case report of a patient with III-grade glioma who achieved stable disease (SD) and clinical improvement after trametinib administration. We also report a review of the literature to Current Treatment Guidelines of Glioblastoma and new therapeutic strategies based on molecularly targeted therapy. Traditional treatments, including surgery, radiotherapy, and chemotherapy, have many limitations concerning the prognosis of patients with glioblastomas. Unfortunately, these tumors’recur after primary resection in the majority of cases. There is no standard therapy for recurrence of GBM. Targeted therapy offers a promising new treatment strategy. Regardless of those outstanding results much more can be done in the field of therapeutic options. Most urgent concerns include potent combining molecular targeted therapy with other types of treatments, selecting a group of patients for whom they turn out to be the most beneficial, and addressing adverse events of these molecules.
A comparative review on High-Performance Liquid Chromatography (HPLC), Ultra Performance Liquid Chromatography (UPLC) & High-Performance Thin Layer Chromatography (HPTLC) with current updates
Authors: Gupta Manish Kumar , Ghuge Aditya , Parab Manasi , Al-Refaei Yehya , Khandare Anjali , Dand Neha , Waghmare Nilkamal 
Published: January 2023

Abstract
Any chosen analytical method should be subtle, precise, fast and exact to begin the guarantee that the material used in the manufacturing is free of unsolicited impurity, the existence of which may vary the safety and effectiveness of the drug product. The techniques of HPLC and UPLC have established their part in pharmaceutical cleaning validation. High-Performance Liquid Chromatography (HPLC) is the main pharmaceutical and biomedical analysis approach utilized today because it generates highly efficient separations, and in most circumstances, it provides high detection sensitivity. Applying the HPLC method has several advantages compared to other methods, among others, specificity, rapidity, accuracy, precision, and the ease of automation. Due to the aforementioned, most drugs in a multi-component dosage form can be analyzed. Ultra-Performance Liquid Chromatography (UPLC) is a modern-day technique that gives a new track for liquid chromatography. UPLC provides the user with speed of application, resolution and sensitivity. The quantification and separation in UPLC are done under very high pressure (up to 100M Pa). High-Performance Thin Layer Chromatography (HPTLC) has improved and innovative separation efficacy and detection limits. It is a cultured and automated form of Thin Layer Chromatography (TLC) and is based on the use of an optimized silica gel 60 with a significantly smaller particle size than which is used for TLC. The previously stated analytical methods are employed for purity control of chemicals, steroids, pesticides, and water analysis, water-soluble food dyes, vitamins, pesticides in vegetables, fruits, and other foodstuffs. The current updates in the techniques allow us to understand the increased utilization of these methods in the current eras.
Synthetic seeds technology of Salvia officinalis as a method for short-term storage and in vitro propagation of valuable genotypes
Authors: Deja Aleksandra K. 
Published: January 2023

Summary

Introduction: The technological advancements in the production of synthetic seeds are critical for the preservation of valuable genotypes of many herbal plants, including Salvia officinalis – sage.

Objective: The aim of this study was the production, storage and conversion of artificial sage seeds. The technology of synthetic seeds is placing explants capable of regeneration into plants in a protective casing.

Methods: Apical and axillary buds were encapsulated with 1.2% sodium alginate solution, and then dripped in 200 mM CaCl2 solution. Artificial seeds were stored at 4°C for 30 days and then converted on MS medium containing 0.3 mg/l of BAP.

Results: The synthetic seeds technology made it possible to obtain a high level of seeds conversion into plants using apical buds (85.0%), and slightly lower in the case of side buds (62.5%).

Conclusion: The fully developed technology of synthetic seeds made it possible to obtain a high level of plant viability, which may prove useful for the storage of valuable genotypes of sage.
Gingival Enlargement Caused by Calcium Channel Blockers
Authors: Desnica Jana , Vujovic Sanja , Stevanovic Momir , Vasovic Miroslav , Stanisic Dragana , Ognjanovic Irena , Rosic Gvozden , Jankovic Slobodan , Jovicic Nemanja , Kostic Marina 
Published: January 2023

Abstract
Calcium channel blockers, a group of drugs widely used in the treatment of cardiovascular patients, although effective, often cause gingival enlargement, a side effect that is rarely recognized in clinical practice and is not given sufficient importance. Gingival enlargement caused by calcium channel blockers can be localized or generalized, mild or severe. It can negatively affect patients’ appearance, mastication, and speech, thus considerably reducing the quality of life of patients. Risk factors and pathogenesis of this side effect have been the subject of many studies but are still unknown, making this condition a major therapeutic challenge, especially if the cessation of the offending drug is not possible. This study aimed to review the etiology, potential risk factors, pathogenesis, clinical features, and therapy possibilities for gingival enlargement caused by calcium channel blockers.
Systemic Diseases with Oral Manifestations and Their Impact on Health-Related Quality of Life
Authors: Vujovic Sanja , Desnica Jana , Stanisic Dragana , Ognjanovic Irena , Milenkovic Jovana , Stevanovic Momir , Rosic Gvozden , Jovicic Nemanja , Milovanovic Dragan 
Published: January 2023

Abstract
Health-related quality of life is a multidimensional concept established to evaluate the physical, psychological, and social impacts of health conditions on individuals’ well-being. Various tools for measuring health-related quality of life can be categorized into two subsets: generic and disease–specific instruments. The oral cavity can be stricken by a broad range of local and systemic diseases and their systemic treatment modalities. The most common systemic illnesses associated with oral lesions are hematologic disorders, endocrinopathies, neurological disorders, gastrointestinal conditions, mucocutaneous and rheumatic diseases, and neoplastic processes. Their manifestations in the oral cavity are, in most cases, rather nonspecific but should not be overlooked. Oral health is one of the most important parts of overall health, thus it has been proposed that poor oral health may affect health–related quality of life. The presence of oral manifestations of systemic diseases has a negative impact on the daily functioning of patients, decreasing their overall well-being. This article will review the most common systemic diseases with oral manifestations and their impact on the health–related quality of life. Oral health researchers should put a stronger emphasis on the patient-reported quality of life as a primary outcome in future clinical trials. The significance of this area has still not been widely understood in the current dental literature even though it could help improve patients’ health-related quality of life.