bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pendampingan Pengolahan Ikan Gabus Dalam Rangka Meningkatkan Ekonomi Masyarakat Di Kelompok Asuhan Mandiri Toga Gaharu Dan Akrupresur Desa Kartiasa Kecamatan Sambas Kab. Sambas
Authors: Muslimah  , Mahyudi Indra , Istiqamah Nur , Januardi Uray 
Published: June 2023

Ikan gabus (Channa striata) merupakan spesies ikan yang mudah untuk didapatkan di dearah sungai Desa Kartiasa. Ekosistem ikan gabus biasanya tinggal didaerah sungai. Kecenderungan hasil tangkap dari ikan gabus dimanfaatkan masyarakat hanya sebatas memasaknya dengan menggoreng dan disatukan dengan sayuran. Tujuan pengabdian masyarakat ini adalah untuk 1) Memperkenalkan mengenai kandungan gizi dan Protein Ikan Gabus; 2) Membuka peluang untuk dapat menjadikan masyarakat berwirausaha dalam olahan ikan gabus menjadi produk yang siap dipasarkan dan menjadi produk dijadikan produk unggulan masyarakat Desa Kartiasa sehingga meningkatkan pendapatan. Pendekatan yang digunakan dalam pengabdian ini dengan melakukan pengolahan dari spesies ikan gabus menjadi olahan pangan nugget. Dan hasil dari olahan tersebut dilakukan pengemasan termasuk diantaranya adalah label dan pembukuan hasil produk. Jumlah peserta 27 orang dan tergabung dalam kelompok asuhan mandiri Toga Gaharu dan akrupresur yang berada di Desa Kartiasa Kecamatan Sambas. Hasil dari kegiatan ini peserta menjadi lebih tahu dalam pembuatan nugget. Dimana nugget yang dibuat bisa dari bahan ikan dan bahan lain dengan komposisi yang pas dan sesuai takaran, selain itu respon yang diberikan peserta tertarik dan antusias serta merepospon positif dari adanya pengbadian yang telah dilakukan oleh dosen Politeknik Negeri Sambas. Hasil dari kegiatan ini diharapkan menjadi acuan dasar dalam mengembangkan hasil olahan ikan gabus yang memiliki nilai ekonomi dan meningkatkan perekonomian masyarakat khususnya daerah Desa Kartiasa.
EVALUASI E-SERVICE (STUDI KASUS: E-LAYANAN BADAN KEPEGAWAIAN DAERAH PROVINSI SUMATERA SELATAN)
Authors: Aprinda Ria , Cholil Widya 
Published: June 2023

Abstract: This research is based on efforts to improve the quality of government electronic-based services at the Regional Civil Service Agency of South Sumatra Province through website evaluation (e-service). The study was conducted using Kepmenpan-RB No. 859/2019 on seven instruments/dimensions, namely efficiency, trust, convenience, reliability, service, availability of information, and interaction. The method used is Mix-Method. The population data in this study was obtained from the Civil Service Information System of South Sumatra. The number of samples used was 100 respondents using the Slovin formula. Data dissemination using questionnaires to users (ASNs). By using the SPSS 25 tool, validity test results are obtained that state the data is valid. As for the reliability test, cronbach α > 0.70 so it was declared good. From the results of the distribution of respondents' answers, it was found that the index of the e-Service website is in good value.
Pengaruh Literasi Keuangan Dan Literasi Digital Terhadap Preferensi Bank Digital
Authors: Tiffani Ignasia 
Published: June 2023

The rapid development of technology, especially since the Covid-19 pandemic, is affecting the world, and one of them is the financial aspect. Banking is a growing sector that can drive economic growth; by continuing to adapt, banks are adopting digital technology to survive. Currently, the challenges of the digital world are increasing. Banks must not only compete with other banks but also must be able to compete with other financial technology companies. One way to adapt and survive in this era is with the emergence of digital banks. The public must also be educated about these digital banking services because financial and digital literacy must be understood first. This research aims to find out and confirm the relationship between financial literacy and digital literacy with consumer preference for digital banks. This type of research is descriptive research with a quantitative approach using primary data. The results obtained are: Financial literacy partially affects consumer preferences for digital banks; Digital literacy partially affects consumer preferences for digital banks; Financial literacy and digital literacy simultaneously affect consumer preferences for digital banks. This research aims to contribute to the development of digital banks in Indonesia.

Keywords: Bank, Digital Bank, Financial Literacy, Digital Literacy, Consumer Preference

Abstrak
Perkembangan teknologi yang begitu cepat terlebih pula semenjak pandemi covid 19 membawa dampak terhadap dunia, salah satunya kepada pada aspek keuangan. Perbankan merupakan sektor yang berkembang yang dapat mendorong pertumbuhan ekonomi, dengan terus beradaptasi bank mulai mengadopsi teknologi digital agar dapat bertahan. Saat ini tantangan dunia digital semakin meningkat, bank tidak hanya harus bersaing dengan bank lain, tetapi juga harus dapat bersaing dengan perusahaan financial technology lainnya. Salah satu cara untuk beradaptasi dan bertahan di era ini yaitu dengan munculnya bank digital. Masyarakat pun perlu diedukasi tentang layanan perbankan digital tersebut, karena literasi keuangan dan literasi digital harus dipahami terlebih dahulu. Tujuan penelitian ini agar mengetahui dan memastikan hubungan antara literasi keuangan dan literasi digital dengan preferensi konsumen terhadap bank digital. Jenis penelitian ini adalah penelitian deskriptif dengan pendekatan kuantitatif dengan menggunakan data primer. Hasil yang diperoleh yaitu: Literasi keuangan secara parsial berpengaruh terhadap preferensi konsumen akan bank digital; Literasi digital secara parsial berpengaruh terhadap preferensi konsumen akan bank digital; Literasi keuangan dan literasi digital secara simultan berpengaruh terhadap preferensi konsumen akan bank digital. Penelitian ini bertujuan untuk berkontribusi dalam pengembangan bank digital di Indonesia.

Kata kunci: Bank, Bank Digital, Literasi Keuangan, Literasi Digital, Preferensi Konsumen
Meningkatkan Regulasi Diri Untuk Kesiapan Kerja Pada Mahasiswa Tingkat Akhir
Authors: Ida Zura , Susilo Edi , Hermawati Dwi 
Published: June 2023

Mahasiswa tingkat akhir harus mempersiapkan pengetahuan dan keterampilan yang sesuai dengan bidangnya ketika memasuki dunia kerja. Dalam memasuki dunia kerja diperlukan kesiapan kerja salah satunya adalah meningkatkan regulasi diri dimana mahasiswa tingkat akhir harus memiliki kemampuan dalam merencanakan dan mengarahkan perilaku untuk mencapai tujuan tertentu.Tujuan kegiatan ini untuk meningkatkan regulasi diri untuk kesiapan kerja pada mahasiswa tingkat akhir dengan metode ceramah dan pelatihan regulasi diri. Alat ukur yang digunakan adalah skala regulasi diri. Hasil dari kegiatan ini adanya peningkatan regulasi diri untuk kesiapan kerja pada mahasiswa tingkat akhir.
5th Hyphotesis Consideration of UTAUT for IOT By Exploiting ACO based Classification
Authors: Ariyanto Rudy , Lestari Vivin Ayu , Sukmana Septian Enggar 
Published: June 2023

Internet of things (IoT) application needs to be evaluated to gain better improvement and innovation. The evaluation can be examined from user acceptance. The unifiedÂ theory of acceptance and use of technology (UTAUT) can be used as a model to identify user acceptance in using technology, including IoT application. However, the ease of use of technology must be included, so the determining of easy of use from negative aspects must be included, so the 5th hypothesis of UTAUT (hindering condition) must be included. Before this hypothesis is formulated and included in evaluation by the user, obtaining data to identify the real condition of the user is performed using forensic analysis and ACO based classification. To evaluate this activity, this 5th hypothesis is measured by reliability and validity test, also hypothesis testing itself.
Sequential Model for Mapping Compound Emotions in Indonesian Sentences
Authors: Aripin - , Agastya Wisnu , Haryanto Hanny 
Published: June 2023

This research proposes mapping Indonesian sentences with single and multiple structures into emotion classes based on a multi-label classification process. The result of this research can apply in various fields, including the development of facial expressions in virtual character animation. Applications in other fields are facial expression analysis, human-computer interaction systems, and other virtual facial character system applications. In previous research, the classification process used for emotion mapping was usually based only on the frequency of occurrence of adjectives. The resulting emotion classes are less representative of sentence semantics. In this research, the proposed sequential model can take into account the semantics of the sentence so that the results of the classification process are more natural and representative of the semantics of the sentence. The method used for the emotion mapping process is multi-label text classification with continuous values between 0-1. This research produces the tolerant-method that utilizes the error value to deliver accuracy in the model evaluation process. The tolerant-method converts the predicted-label, which has an error value less than or equal to the error-tolerant value, to the actual-label for better accuracy. The model used in the classification process is a sequential model, including one-dimensional Convolution Neural Networks (CNN) and bidirectional Long Short-Term Memory (LSTM). The CNN model generates feature maps of each input in a partial way. Meanwhile, bidirectional LSTM captures information from input data in two directions. Experiments were performed using test data on Indonesian sentences. Based on the experimental results, bidirectional LSTM can produce an accuracy of 91% in the 8: 2 data portion and error-tolerant of 0.09.Keywords : Sequential Model, Mapping Compound Emotions, Sentence Semantics, Indonesian Sentences
IMPLEMENTATION OF DIVIDE AND CONQUER IN THE HANOI TOWER GAME
Authors: Indriyono Bonifacius Vicky , Pratama Zudha 
Published: June 2023

Artificial Intelligence (AI) is a technology in the field of computer science that simulates human intelligence into computers to solve various problems and jobs as well as humans do. Games / games are an implementation of the field of computer science which also embraces the concept of AI. In the midst of the rampant types of games available, the author chose the Hanoi Tower which is a mathematical game / puzzle that requires logic. Players are challenged to complete in a short time with a certain number of discs. The benefit of this game is that it can train how to think with certain patterns so as to improve the memory of players. To make it easier to solve it, the Divide and Conquer Algorithm can be used which can solve problems in the Tower of Hanoi game by breaking them down into sub-problems which will later be able to help speed up finding solutions. From the results of testing the application of the Divide and Conquer Algorithm in the hanoi tower game application by solving the disk arrangement problem. Players can finish the game in a large number of plates in a short time. Keywords – Artificial Intelligence, Divide and Conquer Algorithm, Games, Tower of Hanoi.
Vascular response to the microcirculation in the fingertip by local vibration with varied amplitude
Authors: Mu Lizhong , Sun Aoran , Chen Youqiang , Chen Huimin , Li Jianda , Linghu Bingqi , Zhou Hang , Chi Qingzhuo , Luan Xiaofeng , Pan Yue 
Published: June 2023

Objectives: We investigated the effect of local vibration intensity on the vascular response to the microcirculation of the finger.Materials and methods: We performed hand-transmitted vibration experiments combined with laser Doppler flowmetry (LDF) to measure the blood perfusion signals of fingertips in the vibrated hand and the contralateral middle finger under the same frequency and different amplitude vibration, and to analyze the changes of microcirculatory blood perfusion levels in the fingers, and to investigate the effects of vibration stimulation on the endothelial, neural and myogenic regulatory frequency ranges of fingertips based on wavelet analysis. Furthermore, the transparent silicone films were fabricated and cultured with vascular endothelial cell (EC), which will undergo the local vibration with varied amplitude. And the expression of inflammatory factors was detected in the ECs.Results: Low-frequency vibration leads to a decreased blood flow in fingertip, and the degree of reduction in fingertip blood flow increases as the amplitude gradually increases, and the period required for blood flow to return to normal level after hand-transmitted vibration gradually increases. The decrease in blood flow is more pronounced in the vibrating hand than in the contralateral hand. In addition, nuclear factor-κB (NF-κB) expression increased significantly with the increase of vibration amplitude.Conclusion: High amplitude vibrations caused the inflammatory reaction of ECs which will lead to the altered endothelial regulatory activity. The endothelial regulatory activity is closely related to the blood perfusion in the microcirculation.
Quantum-based modeling implies that bidentate Arg89-substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation
Authors: Salter E. Alan , Wierzbicki Andrzej , Honkanen Richard E. , Swingle Mark R. 
Published: June 2023

PP2A-serine/threonine protein phosphatases function as heterotrimeric holoenzymes, composed of a common scaffold (A-subunit encoded by PPP2R1A/PPP2R1B), a common catalytic (C-subunit encoded by PPP2CA/PPP2CB), and one of many variable regulatory (B) subunits. The site of phosphoprotein phosphatase (PPP) hydrolysis features a bimetal system (M1/M2), an associated bridge hydroxide [W1(OH−)], and a highly-conserved core sequence. In the presumptive common mechanism, the phosphoprotein’s seryl/threonyl phosphate coordinates the M1/M2 system, W1(OH−) attacks the central P atom, rupturing the antipodal bond, and simultaneously, a histidine/aspartate tandem protonates the exiting seryl/threonyl alkoxide. Based on studies of PPP5C, a conserved arginine proximal to M1 is also expected to bind the substrate’s phosphate group in a bidentate fashion. However, in PP2A isozymes, the role of the arginine (Arg89) in hydrolysis is not clear because two independent structures for PP2A(PPP2R5C) and PP2A(PPP2R5D) show that Arg89 engages in a weak salt bridge at the B:C interface. These observations raise the question of whether hydrolysis proceeds with or without direct involvement of Arg89. The interaction of Arg89 with B:Glu198 in PP2A(PPP2R5D) is significant because the pathogenic E198K variant of B56δ is associated with irregular protein phosphorylation levels and consequent developmental disorders (Jordan’s Syndrome; OMIM #616355). In this study, we perform quantum-based hybrid [ONIOM(UB3LYP/6-31G(d):UPM7)] calculations on 39-residue models of the PP2A(PPP2R5D)/pSer (phosphoserine) system to estimate activation barriers for hydrolysis in the presence of bidentate Arg89-substrate binding and when Arg89 is otherwise engaged in the salt-bridge interaction. Our solvation-corrected results yield ΔH‡ ≈ ΔE‡ = +15.5 kcal/mol for the former case, versus +18.8 kcal/mol for the latter, indicating that bidentate Arg89-substrate binding is critical for optimal catalytic function of the enzyme. We speculate that PP2A(PPP2R5D) activity is suppressed by B:Glu198 sequestration of C:Arg89 under native conditions, whereas the PP2A(PPP2R5D)-holoenzyme containing the E198K variant has a positively-charged lysine in this position that alters normal function.
Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinoma
Authors: Battaglia Anna Martina , Sacco Alessandro , Aversa Ilenia , Santamaria Gianluca , Palmieri Camillo , Botta Cirino , De Stefano Roberto , Bitetto Maurizio , Petriaggi Lavinia , Giorgio Emanuele , Faniello Concetta Maria , Costanzo Francesco , Biamonte Flavia 
Published: June 2023

Introduction: The PD-1/PD-L1 axis is hijacked by lung adenocarcinoma (LUAD) cells to escape immune surveillance. PD-L1 expression in LUAD is affected, among others, by the metabolic trafficking between tumor cells and the tumor microenvironment (TME).Methods: Correlation between PD-L1 expression and iron content within the TME was established on FFPE LUAD tissue samples. The effects of an iron rich microenvironment on PD-L1 mRNA and protein levels were assessed in vitro in H460 and A549 LUAD by using qPCR, western blot and flow citometry. c-Myc knockdown was performed to validate the role of this transcription factor on PD-L1 expression. The effects of iron-induced PD-L1 on T cell immune function was assessed by quantifying IFN-γ release in a co-colture system. TCGA dataset was used to analyse the correlation between PD-L1 and CD71 mRNA expression in LUAD patients.Results: In this study, we highlight a significant correlation between iron density within the TME and PD-L1 expression in 16 LUAD tissue specimens. In agreement, we show that a more pronounced innate iron-addicted phenotype, indicated by a higher transferrin receptor CD71 levels, significantly correlates with higher PD-L1 mRNA expression levels in LUAD dataset obtained from TCGA database. In vitro, we demonstrate that the addition of Fe3+ within the culture media promotes the significant overexpression of PD-L1 in A549 and H460 LUAD cells, through the modulation of its gene transcription mediated by c-Myc. The effects of iron lean on its redox activity since PD-L1 up-regulation is counteracted by treatment with the antioxidant compound trolox. When LUAD cells are co-cultured with CD3/CD28-stimulated T cells in an iron-rich culture condition, PD-L1 up-regulation causes the inhibition of T-lymphocytes activity, as demonstrated by the significant reduction of IFN-γ release.Discussion: Overall, in this study we demonstrate that iron abundance within the TME may enhance PD-L1 expression in LUAD and, thus, open the way for the identification of possible combinatorial strategies that take into account the iron levels within the TME to improve the outcomes of LUAD patients treated with anti-PD-1/PD-L1-based therapies.
Risk factors for colonization with multidrug-resistant Gram-negative bacteria and Clostridioides difficile in Long Term Care Facilities (LTCFs) residents: the evidence from 27 facilities in a high endemic setting
Authors: Azzini Anna Maria , Be Giorgia , Naso Laura , Lambertenghi Lorenza , Salerno Nicola Duccio , Coledan Ilaria , Bazaj Alda , Mirandola Massimo , Miotti Jessica , Mazzaferri Fulvia , Accordini Simone , Lo Cascio Giuliana , Tacconelli Evelina 
Published: June 2023

IntroductionResidency in LTCFs increases the likelihood of colonization with multidrug resistant Gram-negative bacteria (MDR-GNB). We assessed the prevalence and risk factors for enteric colonization by III-generation cephalosporins-resistant and carbapenem-resistant (CR) GNB in a large group of LTCFs in a high endemic setting. We also assessed the prevalence and risk factors for C. difficile colonization.MethodsA point prevalence survey with rectal screening (RS) was conducted in 27 LTCFs in north Italy. Epidemiological and clinical variables on the survey day, history of hospitalization and surgery within one year, and antibiotics within three months, were collected. The presence of III-generation cephalosporin resistant and CR GNB was assessed using a selective culture on chromogenic medium and PCR for carbapenemase detection. The presence of C. difficile was assessed using ELISA for GDH and RT-PCR to identify toxigenic strains. Multi-variable analyses were performed using two-level logistic regression models.ResultsIn the study period 1947 RSs were performed. The prevalence of colonization by at least one GNB resistant to III-generation cephalosporin was 51% (E. coli 65%, K. pneumoniae 14% of isolates). The prevalence of colonization by CR GNB was 6%. 6% of all isolates (1150 strains) resulted in a carbapenem-resistant K. pneumoniae, and 3% in a carbapenem-resistant E. coli. KPC was the most frequent carbapenemase (73%) identified by PCR, followed by VIM (23%). The prevalence of colonization by C. difficile was 11.7%. The presence of a medical device (OR 2.67) and previous antibiotic use (OR 1.48) were significantly associated with III-generation cephalosporin resistant GNB colonization. The presence of a medical device (OR 2.67) and previous hospitalization (OR 1.80) were significantly associated with CR GNB. The presence of a medical device (OR 2.30) was significantly associated with C. difficile colonization. Main previously used antibiotic classes were fluoroquinolones (32% of previously treated subjects), III-generation cephalosporins (21%), and penicillins (19%).ConclusionAntimicrobial stewardship in LTCFs is a critical issue, being previous antibiotic treatment a risk factor for colonization by MDR-GNB. The prevalence of colonization by III-generation cephalosporin and CR GNB among LTCF residents also underlines the importance to adhere to hand hygiene indications, infection prevention and control measures, and environmental hygiene protocols, more achievable than rigorous contact precautions in this type of social setting.
Case report: Stenosis turned leak … and turned stenosis—complications of paravalvular prosthetic leak closure with a plug device
Authors: Pitta Gros Barbara , Roux Olivier , Eeckhout Eric , Kirsch Matthias 
Published: June 2023

BackgroundParavalvular leak is one of the most common complications and is among the most important prognostic factors of short- and long-term mortality after transcatheter aortic valve implantation (TAVI). Percutaneous valvular leak repair constitutes a first-line treatment for paravalvular leaks and is associated with high success rates and few serious complications nowadays. To the best of our knowledge, this is the first case where placement of the device through the stenting of the bioprosthesis resulted in creating a new symptomatic stenosis that required surgery.Case summaryWe present a case of a patient with low-flow, low-gradient aortic stenosis treated with transfemoral implantation of a biological aortic prosthesis. One month after the procedure, the patient presented with acute pulmonary oedema and a paravalvular leak was discovered, which was corrected by percutaneous repair with a plug device. Five weeks after the valvular leak repair, the patient was readmitted for heart failure. At this time, a new aortic stenosis and paravalvular leak were diagnosed and the patient was referred for surgery. The new aortic mixed diseased was caused by the positioning of the plug device through the valve's metal stenting, which resulted in a paravalvular leak and pressed against the valve's leaflets, causing valvular stenosis. The patient was referred for surgical replacement and evolved well afterward.ConclusionThis case illustrates a rare complication of a complex procedure, and it highlights the need for multidisciplinary decisions and good cooperation between the cardiology and cardiac surgery teams to develop better criteria in the selection of the appropriate technique for managing paravalvular leaks after TAVI.