bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laboratory evaluation of anti-plaque and remineralization efficacy of sugarless probiotic jelly candy supplemented with natural nano prebiotic additive
Authors: Elgamily Hanaa M. , El-Sayed Samah M. , El-Sayed Hoda S. , Youssef Ahmed M. 
Published: July 2023

AbstractWe evaluated the anti-cariogenic effect of an experimental synbiotic compound containing probiotic Lacticaseibacillus rhamnosus (NRRL B-442)-based jelly candy supplemented with natural prebiotic grape seed extract (GSE) in a nanoemulsion formula on the colonization and establishment of Streptococcus mutans (ATCC 25175) and Actinomyces viscosus (ATTCC 19246) biofilms through counting colony forming units, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). We were then analysing the remineralizing effect of synbiotic jelly candy on human enamel surface lesions using Vickers microhardness testers, atomic force microscopy (AFM), SEM, energy-dispersive X-ray spectroscopy (EDAX), and confocal laser scanning microscopy (CLSM) at three stages (sound, after demineralization, and after pH cycling). We found after 21 days of treatment of the pH-cycled enamel discs with jelly candy for 10 min twice daily, a 68% decrease in S. mutans colony formation, reducing biofilm development, trapping S. mutans visualized in jelly candy under SEM examination, and significantly altering the morphological structure of these bacteria under TEM analysis. For remineralization measurements, statistically significant differences in microhardness integrated mineral loss, and lesion depth through CLSM between demineralization and treatment stages. These findings provide an effective anti-cariogenic synbiotic compound of grape seed extract and probiotic jelly candy with potential remineralizing activity.
Feasibility of using KardiaMobile-L6 for QT interval monitoring during the early phase of the COVID-19 pandemic in critical care patients
Authors: Zaballos Matilde , Fernández Ignacio , Rodríguez Lucia , Orozco Silvia , García Amparo , Juncos Mónica , Alvarez-Zaballos Sara , Piñeiro Patricia , Hortal Javier 
Published: July 2023

AbstractThe electrocardiogram (ECG) represents an essential tool to determine cardiac electrical abnormalities in COVID-19 patients, the effects of anti-SARS-CoV-2 drugs, and potential drug interactions. Smartphone-based heart monitors have increased the spectrum of ECG monitoring however, we are not aware of its reliability in critically ill COVID-19 patients. We aim to evaluate the feasibility and reliability of nurse-performed smartphone electrocardiography for QT interval monitoring in critically ill COVID-19 patients using KardiaMobile-6L compared with the standard 12-lead ECG. An observational comparative study was conducted comparing consecutive KardiaMobile-6L and 12-lead ECG recordings obtained from 20 patients admitted to the intensive care unit with SARS-CoV-2 infection and on invasive mechanical ventilation. The heart rate-corrected QT (QTc) intervals measured by KardiaMobile-6L and 12-lead ECG were compared. In 60 percent of the recordings, QTc intervals measured by KardiaMobile-6L matched those by 12-lead ECG. The QTc intervals measured by KardiaMobile-6 and 12-lead ECG were 428 ± 45 ms and 425 ± 35 ms (p = 0.82), respectively. The former demonstrated good agreement (bias = 2.9 ms; standard deviation of bias = 29.6 ms) with the latter, using the Bland–Altman method of measurement agreement. In all but one recording, KardiaMobile-6L demonstrated QTc prolongation. QTc interval monitoring with KardiaMobile-6L in critically ill COVID-19 patients was feasible and demonstrated reliability comparable to the standard 12-lead ECG.
Optical and radiation shielding properties of PVC/BiVO4 nanocomposite
Authors: Kassem Said M. , Abdel Maksoud M. I. A. , El Sayed Adel M. , Ebraheem S. , Helal A. I. , Ebaid Y. Y. 
Published: July 2023

AbstractThis study investigates the physical and optical properties as well as the radiation shielding capacity of polyvinyl chloride (PVC) loaded with x% of bismuth vanadate (BiVO4) (x = 0, 1, 3, and 6 wt%). As a non-toxic nanofiller, the designed materials are low-cost, flexible, and lightweight plastic to replace traditional lead, which is toxic and dense. XRD patterns and FTIR spectra demonstrated a successful fabrication and complexation of nanocomposite films. In addition, the particle size, morphology, and elemental composition of the BiVO4 nanofiller were demonstrated through the utilization of TEM, SEM, and EDX spectra. The MCNP5 simulation code assessed the gamma-ray shielding effectiveness of four PVC + x% BiVO4 nanocomposites. The obtained mass attenuation coefficient data of the developed nanocomposites were comparable to the theoretical calculation performed with Phy-X/PSD software. Moreover, the initial stage in the computation of various shielding parameters, such as half-value layer, tenth value layer, and mean free path, besides the simulation of linear attenuation coefficient. The transmission factor declines while radiation protection efficiency increases with an increase in the proportion of BiVO4 nanofiller. Further, the current investigation seeks to evaluate the thickness equivalent (Xeq), effective atomic number (Zeff), and effective electron density (Neff) values as a function of the concentration of BiVO4 in a PVC matrix. The results obtained from the parameters indicate that incorporating BiVO4 into PVC can be an effective strategy for developing sustainable and lead-free polymer nanocomposites, with potential uses in radiation shielding applications.
A novel investigation using thermal modeling and optimization of waste pyrolysis reactor using finite element analysis and response surface methodology
Authors: Garg Shivi , Nayyar Anand , Buradi Abdulrajak , Shadangi Krushna Prasad , Sharma Prabhakar , Bora Bhaskor Jyoti , Jain Akshay , Asif Shah Mohd 
Published: July 2023

AbstractThe influence of humans on the environment is growing drastically and is pervasive. If this trend continues for a longer time, it can cost humankind, social and economic challenges. Keeping this situation in mind, renewable energy has paved the way as our saviour. This shift will not only help in reducing pollution but will also provide immense opportunities for the youth to work. This work discusses about various waste management strategies and discusses the pyrolysis process in details. Simulations were done keeping pyrolysis as the base process and by varying parameters like feeds and reactor materials. Different feeds were chosen like Low-Density Polyethylene (LDPE), wheat straw, pinewood, and a mixture of Polystyrene (PS), Polyethylene (PE), and Polypropylene (PP). Different reactor materials were considered namely, stainless steel AISI 202, AISI 302, AISI 304, and AISI 405. AISI stands for American Iron and Steel Institute. AISI is used to signify some standard grades of alloy steel bars. Thermal stress and thermal strain values and temperature contours were obtained using simulation software called Fusion 360. These values were plotted against temperature using graphing software called Origin. It was observed that these values increased with increasing temperature. LDPE got the lowest values for stress and stainless steel AISI 304 came out to be the most feasible material for pyrolysis reactor having the ability to withstand high thermal stresses. RSM was effectively used to generate a robust prognostic model with high efficiency, R2 (0.9924–0.9931), and low RMSE (0.236 to 0.347). Optimization based on desirability identified the operating parameters as 354 °C temperature and LDPE feedstock. The best thermal stress and strain responses at these ideal parameters were 1719.67 MPa and 0.0095, respectively.
Effect of continuous sugarcane bagasse-derived biochar application on rainfed cotton (Gossypium hirsutum L.) growth, yield and lint quality in the humid Mississippi delta
Authors: Pinnamaneni Srinivasa R. , Lima Isabel , Boone Stephanie A. , Anapalli Saseendran S. , Reddy Krishna N. 
Published: July 2023

AbstractOptimizing soil health through soil amendments is a promising strategy for enhancing rainwater efficiency for stabilizing crop production. Biochar, obtained by torrefaction of sugarcane bagasse, a byproduct from sugar mills, has a high potential for its use as a soil amendment, which can boost crop yields, but needs further field trials for its adoption in farming systems. A field study was conducted during 2019–2021 at Stoneville, Mississippi, to assess rainfed cotton (Gossypium hirsutum L.) production under four biochar levels (0, 10, 20, and 40 t ha−1) on Dundee silt loam soil. The effects of biochar on cotton growth and lint yield and quality were examined. Biochar levels had no significant impact on cotton lint and seed yield for the first two years. Still, in the third year, a significant increase in lint yield by 13 and 21.7% was recorded at 20 and 40 t ha−1 biochar levels, respectively. In the third year, lint yields were 1523, 1586, 1721, and 1854 kg ha−1 at 0, 10, 20 and 40 t ha−1 biochar levels, respectively. Similarly, cotton seed yield increased by 10.8% and 13.4% in 20 and 40 t ha−1 biochar plots. This study demonstrated that successive biochar applications at 20 or 40 t ha−1 can enhance cotton lint and seed yields under rainfed conditions. These improved yields with biochar did not produce increased net returns due to the increased production costs. Many lint quality parameters were unaffected except for micronaire, fiber strength and fiber length. However, potential long-term benefits of enhanced cotton production from biochar application beyond the length of the study merit further investigation. Additionally, biochar application is more relevant when accrued carbon credits through carbon sequestration outweigh the increased production costs due to biochar application.
CYP4F12 is a potential biomarker and inhibits cell migration of head and neck squamous cell carcinoma via EMT pathway
Authors: Jia Wenming , Chen Shuai , Wei Ran , Yang Xiaoqi , Zhang Minfa , Qian Ye , Liu Heng , Lei Dapeng 
Published: July 2023

AbstractHead and neck squamous cell carcinoma (HNSC) is the most common malignant tumor of head and neck. Due to the insidious nature of HNSC and the lack of effective early diagnostic indicators, the development of novel biomarkers to improve patient prognosis is particularly urgent. In this study, we explored and validated the correlation between cytochrome P450 family 4 subfamily F member 12 (CYP4F12) expression levels and HNSC progression using data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) datasets and collected patient samples. We analyzed the association of CYP4F12 expression with clinicopathological features, immune correlation and prognosis. Finally, we analyzed the correlation between CYP4F12 and pathways, and verified by experiments. The results showed that CYP4F12 was low expressed in tumor tissues, participated in a variety of phenotypic changes of HNSC and affected immune cell infiltration. Pathway analysis indicated that CYP4F12 may play a key role in tumor cell migration and apoptosis. Experimental results showed that over-expression of CYP4F12 inhibited cell migration and enhanced the adhesion between cells and matrix by inhibiting epithelial-mesenchymal transition (EMT) pathway in HNSC cells. In conclusion, our study provided insights into the role of CYP4F12 in HNSC and revealed that CYP4F12 may be a potential therapeutic target for HNSC.
Experimental study on flow and turbulence characteristics of jet impinging on cylinder using three-dimensional Lagrangian particle tracking velocimetry
Authors: Kim Mirae , Schanz Daniel , Novara Matteo , Godbersen Philipp , Yeom Eunseop , Schröder Andreas 
Published: July 2023

AbstractWhen a round jet impinges on a convex cylindrical surface, complex three-dimensional (3D) flow structures occur, accompanied by the Coanda effect. To characterize the flow and turbulence properties of the general system, ensemble averages of 3D Lagrangian particle tracking velocimetry measurements were taken. The radial bin-averaging method was used in post-processing the tracked particles and corresponding instantaneous velocity vectors to generate appropriate ensemble-averaged statistics. Two impinging angles were selected, and at a fixed Reynolds number, the ensemble-averaged volumetric velocity field and turbulent stress tensor components were measured. The flow and turbulence characteristics of the impinging jet on the cylinder were notably different based on the impinging angle, especially in the downstream region. Surprisingly, the attached wall jet with a half-elliptic shape was abruptly thickened in the wall-normal direction, similar to the axis switching phenomenon observed in elliptic jets in the case of oblique impingement. In the jet-impinging region, the flow spread in all directions with high mean vorticity values. With the development of a 3D curved wall jet, both the Coanda effect and centrifugal force played a significant role in the flow behavior. A notable feature of the self-preserving region was the similarity of mean velocity profiles with scaling by the maximum velocity and the jet half-width for both impinging angle cases. Local isotropy of turbulent normal stresses was observed in this region, supporting the existence of self-preservation in the 3D curved wall jet. The volumetric ensemble-averaged Reynolds stress tensor revealed strong inhomogeneous turbulence in the boundary layer region and the curvature effect on the Reynolds shear stress in the free shear layer.
On the yield criterion of porous materials by the homogenization approach and Steigmann–Ogden surface model
Authors: Zheng Chenyi , Wang Hongzhen , Jiang Yali , Li Gaohui 
Published: July 2023

AbstractIn this work, we investigate the yield criterion of nanoporous materials by using homogenization approach and Steigmann–Ogden surface model. The representative volume element is proposed as an infinite matrix containing a tiny nanovoid. The matrix is incompressible, rigid-perfectly plastic, von Mises materials and nanovoids are dilute and equal in size. First, the constitutive of microscopic stress and microscopic strain rate is established based on the flow criterion. Secondly, according to the Hill’s lemma, the relationship between the macroscopic equivalent modulus and the microscopic equivalent modulus is established by homogenization approach. Thirdly, the macroscopic equivalent modulus containing the Steigmann–Ogden surface model including surface parameters, porosity and nanovoid radius is derived from the trial microscopic velocity field. Finally, an implicit macroscopic yield criterion for nanoporous materials is developed. For surface modulus, nanovoids radius and porosity studies are developed through extensive numerical experiments. The research results in this paper have reference significance for the design and manufacture of nanoporous materials.
Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling
Authors: Pontarollo Giulia , Kollar Bettina , Mann Amrit , Khuu My Phung , Kiouptsi Klytaimnistra , Bayer Franziska , Brandão Inês , Zinina Valeriya V. , Hahlbrock Jennifer , Malinarich Frano , Mimmler Maximilian , Bhushan Sudhanshu , Marini Federico , Ruf Wolfram , Belheouane Meriem , Baines John F. , Endres Kristina , Reba Scott M. , Raker Verena K. , Deppermann Carsten , Welsch Christoph , Bosmann Markus , Soshnikova Natalia , Chassaing Benoit , Bergentall Mattias , Sommer Felix , Bäckhed Fredrik , Reinhardt Christoph 
Published: July 2023

AbstractThe gut microbiota influences intestinal barrier integrity through mechanisms that are incompletely understood. Here we show that the commensal microbiota weakens the intestinal barrier by suppressing epithelial neuropilin-1 (NRP1) and Hedgehog (Hh) signaling. Microbial colonization of germ-free mice dampens signaling of the intestinal Hh pathway through epithelial Toll-like receptor (TLR)-2, resulting in decreased epithelial NRP1 protein levels. Following activation via TLR2/TLR6, epithelial NRP1, a positive-feedback regulator of Hh signaling, is lysosomally degraded. Conversely, elevated epithelial NRP1 levels in germ-free mice are associated with a strengthened gut barrier. Functionally, intestinal epithelial cell-specific Nrp1 deficiency (Nrp1ΔIEC) results in decreased Hh pathway activity and a weakened gut barrier. In addition, Nrp1ΔIEC mice have a reduced density of capillary networks in their small intestinal villus structures. Collectively, our results reveal a role for the commensal microbiota and epithelial NRP1 signaling in the regulation of intestinal barrier function through postnatal control of Hh signaling.
Generational differences in climate-related beliefs, risk perceptions and emotions in the UK
Authors: Poortinga Wouter , Demski Christina , Steentjes Katharine 
Published: July 2023

AbstractIt is widely believed that younger generations are more engaged with climate change than older generations. However, evidence of a gap in climate-related perceptions and concern is mixed, likely due to the inconsistent use of outcome variables. Here we systematically examine generational differences across different types of climate engagement including cognitive and affective dimensions. Using data from three nationally-representative surveys conducted in the UK in 2020, 2021 and 2022, we show there is an overall pattern of higher levels of climate-related beliefs, risks perceptions and emotions among younger generation groups. However, the gap is larger and more consistent for climate-related emotions than for climate-related beliefs. While generational differences in climate-related emotions were found across all years, the overall gap has disappeared due to narrowing climate-related beliefs and risk perceptions. The generational differences are therefore mainly in emotional engagement rather than in beliefs about anthropogenic climate change.
The diurnal variation of wet bulb temperatures and exceedance of physiological thresholds relevant to human health in South Asia
Authors: Justine Jenix , Monteiro Joy Merwin , Shah Hardik , Rao Neethi 
Published: July 2023

AbstractExtreme heat is increasingly being acknowledged as a serious hazard to human health, through a combination of physiological responses to heat, expressed as dry and wet bulb temperatures, and personal factors. Here we present an analysis of the diurnal variability of dry and wet bulb temperatures using station data in South Asia during both regular and heatwave days. We find that diurnal cycles differ, with the daily maximum wet bulb temperature occurring several hours after the daily maximum dry bulb temperature. Using radiosonde profiles, we show that the timing and amplitude of the diurnal variability of wet bulb temperature can be explained by changes in boundary layer depths and water content. Physiological thresholds for uncompensable heat stress were exceeded even in the evenings, many hours after dry bulb temperature peaks. Cumulative exceedances occurred in 105 instances, corresponding to at least 300 hours of exposure to uncompensable heat stress in South Asia between 1995 and 2020. We conclude that physiologically relevant thresholds provide a more robust way to estimate health impacts, and that wet bulb temperature alone is insufficient as an indicator of hazardous heat.
Neural ADMIXTURE for rapid genomic clustering
Authors: Dominguez Mantes Albert , Mas Montserrat Daniel , Bustamante Carlos D. , Giró-i-Nieto Xavier , Ioannidis Alexander G. 
Published: July 2023

AbstractCharacterizing the genetic structure of large cohorts has become increasingly important as genetic studies extend to massive, increasingly diverse biobanks. Popular methods decompose individual genomes into fractional cluster assignments with each cluster representing a vector of DNA variant frequencies. However, with rapidly increasing biobank sizes, these methods have become computationally intractable. Here we present Neural ADMIXTURE, a neural network autoencoder that follows the same modeling assumptions as the current standard algorithm, ADMIXTURE, while reducing the compute time by orders of magnitude surpassing even the fastest alternatives. One month of continuous compute using ADMIXTURE can be reduced to just hours with Neural ADMIXTURE. A multi-head approach allows Neural ADMIXTURE to offer even further acceleration by computing multiple cluster numbers in a single run. Furthermore, the models can be stored, allowing cluster assignment to be performed on new data in linear time without needing to share the training samples.
Health Information Exchange: Understanding the Policy Landscape and Future of Data Interoperability
Authors: Holmgren A Jay , Esdar Moritz , Hüsers Jens , Coutinho-Almeida João 
Published: July 2023

Objectives: To review recent literature on health information exchange (HIE), focusing on the policy approach of five case study nations: the United States of America, the United Kingdom, Germany, Israel, and Portugal, as well as synthesize lessons learned across countries and provide recommendations for future research.
Methods: A narrative review of each nation’s HIE policy frameworks, current state, and future HIE strategy.
Results: Key themes that emerged include the importance of both central decision-making as well as local innovation, the multiple and complex challenges of broad HIE adoption, and the varying role of HIE across different national health system structures.
Conclusion: HIE is an increasingly important capability and policy priority as electronic health record (EHR) adoption becomes more common and care delivery is increasingly digitized. While all five case study nations have adopted some level of HIE, there are significant differences across their level of data sharing infrastructure and maturity, and each nation took a different policy approach. While identifying generalizable strategies across disparate international systems is challenging, there are several common themes across successful HIE policy frameworks, such as the importance of central government prioritization of data sharing. Finally, we make several recommendations for future research to expand the breadth and depth of the literature on HIE and guide future decision-making by policymakers and practitioners.
Health Equity in Clinical Research Informatics
Authors: Maurud Sigurd , Henni Silje H. , Moen Anne 
Published: July 2023

Objectives: Through a scoping review, we examine in this survey what ways health equity has been promoted in clinical research informatics with patient implications and especially published in the year of 2021 (and some in 2022).
Method: A scoping review was conducted guided by using methods described in the Joanna Briggs Institute Manual. The review process consisted of five stages: 1) development of aim and research question, 2) literature search, 3) literature screening and selection, 4) data extraction, and 5) accumulate and report results.
Results: From the 478 identified papers in 2021 on the topic of clinical research informatics with focus on health equity as a patient implication, 8 papers met our inclusion criteria. All included papers focused on artificial intelligence (AI) technology. The papers addressed health equity in clinical research informatics either through the exposure of inequity in AI-based solutions or using AI as a tool for promoting health equity in the delivery of healthcare services. While algorithmic bias poses a risk to health equity within AI-based solutions, AI has also uncovered inequity in traditional treatment and demonstrated effective complements and alternatives that promotes health equity.
Conclusions: Clinical research informatics with implications for patients still face challenges of ethical nature and clinical value. However, used prudently—for the right purpose in the right context—clinical research informatics could bring powerful tools in advancing health equity in patient care.