bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling nanofluid viscosity: comparing models and optimizing feature selection—a novel approach
Authors: Onyiriuka Ekene 
Published: September 2023

Abstract
Background
The accurate prediction of viscosity in nanofluids is essential for comprehending their flow behavior and enhancing their effectiveness in different industries. This research delves into modeling the viscosity of nanofluids and assessing various models through cross-validation techniques. The models are compared based on the root mean square error of the cross-validation sets, which served as the selection criteria.

The main body of the abstract
Four feature selection algorithms namely the minimum redundancy maximum relevance, F-test, RReliefF were evaluated to identify the most influential features for viscosity prediction. The feature selection based on physical meaning was the algorithm that yielded the best results, as outlined in this study. This methodology takes into account the physical relevance of most aspects of the nanofluid's viscosity. To assess the predictive performance of the models, a cross-validation process was conducted, which provided a robust evaluation. The root mean squared error of the validation sets was used to compare the models. This rigorous evaluation identified the most accurate and reliable model for predicting nanofluid viscosity.

Results
The results showed that the novel feature selection algorithm outclassed the established approaches in predicting the viscosity of single material nanofluid. The proposed feature selection algorithm had a root mean squared error of 0.022 and an r squared value of 0.9941 for the validation set, while for the test set, the root mean squared error was 0.0146, the mean squared error was 0.0157, the r squared value was 0.9924.

Conclusions
This research provides valuable insights into nanofluid viscosity and offers guidance on choosing the most suitable features for viscosity modeling. The study also highlights the importance of using physical meaning to select features and cross-validation to assess model performance. The models developed in this study can be helpful in predicting nanofluid viscosity and optimizing their use in different industrial processes.
Predictive modelling of thermal conductivity in single-material nanofluids: a novel approach
Authors: Onyiriuka Ekene 
Published: September 2023

Abstract
Background
This research introduces a novel approach for modelling single-material nanofluids, considering the constituents and characteristics of the fluids under investigation. The primary focus of this study was to develop models for predicting the thermal conductivity of nanofluids using a range of machine learning algorithms, including ensembles, trees, neural networks, linear regression, Gaussian process regressors, and support vector machines.

The main body of the abstract
To identify the most relevant features for accurate thermal conductivity prediction, the study compared the performance of established feature selection algorithms, such as minimum redundancy maximum relevance, Ftest, and RReliefF, a newly proposed feature selection algorithm. The novel algorithm eliminated features lacking direct implications for fluid thermal conductivity. The selected features included temperature as a thermal property of the fluid itself, multiphase features such as volume fraction and particle size, and material features including nanoparticle material and base fluid material, which could be fixed based on any two intensive properties. Statistical methods were employed to select the features accordingly.

Results
The results demonstrated that the novel feature selection algorithm outperformed the established approaches in predicting the thermal conductivity of nanofluids. The models were evaluated using fivefold cross-validation, and the best model was the model based on the proposed feature selection algorithm that exhibited a root-mean-squared error of validation of 1.83 and an R-squared value of 0.94 on validation set. The model achieved a root-mean-squared error of 1.46 and an R-squared value of 0.97 for the test set.

Conclusions
The developed predictive model holds practical significance by enabling nanofluids' numerical study and optimisation before their creation. This model facilitates the customisation of conventional fluids to attain desired fluid properties, particularly their thermal properties. Additionally, the model permits the exploration of numerous nanofluid variations based on permutations of their features. Consequently, this research contributes valuable insights to the design and optimisation of nanofluid systems, advancing our understanding and application of thermal conductivity in nanofluids and introducing a novel and methodological approach for feature selection in machine learning.
Apple Valsa canker: insights into pathogenesis and disease control
Authors: Feng Hao , Wang Chengli , He Yanting , Tang Lin , Han Pengliang , Liang Jiahao , Huang Lili 
Published: September 2023

AbstractApple Valsa canker (AVC) has caused significant losses worldwide, especially in East Asia. Various fungal species from the genus Cytospora/Valsa can infect tree bark and cause tissue rot, and Valsa mali (Vm) is responsible for the most severe tree branch deaths and yield losses. Since AVC was first reported in Japan in 1903, the pathogen species, biological characteristics, infection and pathogenesis, spore dissemination, and disease cycle have been intensively investigated. Based on the new cognition of the disease dynamics, the disease control strategy has shifted from scraping diseased tissue to protecting the bark from infection. In this review, we summarize new knowledge of the Vm infection process mediated by various kinds of virulence factors, including cell wall degrading enzymes, toxins, effectors, microRNA-like RNAs, and pathogenic signaling regulators. We also introduce progress in evaluating germplasm resources and identifying disease response-related genes in apples. In addition, we elaborate current understanding of spore dissemination and disease cycles in orchards and disease prevention techniques. Finally, we provide recommendations for developing more cost-effective strategies for controlling AVC by applying genetic resistance and biological fungicides.
A Novel Variant in NR5A1 Presenting as 46,XY Difference of Sex Development
Authors: Yu Yunting , Lee Peter A , Huerta-Saenz Lina , Allen Natalie G 
Published: September 2023

Abstract
Differences of sex development (DSDs) are a spectrum of congenital clinical conditions involving the development of gonadal, chromosomal, and anatomical sex. The physical presentation provides incomplete clues because underlying etiologies may present with similar findings. We describe an 8-year-old boy from the Dominican Republic originally diagnosed with congenital adrenal hyperplasia (CAH). He was prescribed oral hydrocortisone and fludrocortisone, with irregular adherence. During infancy, he had human chorionic gonadotropin injections to stimulate phallic growth. After migrating to the United States, medications became depleted but without adrenal crisis. Laboratory testing with high-dose adrenocorticotropin stimulation study ruled out CAH. Careful examination noted an underdeveloped bifid scrotum, bilaterally undescended testicles, a 2-cm phallus, severe penoscrotal hypospadias, and chordee. Subsequently, he had a 2-stage bilateral orchiopexy and surgical repair of penoscrotal hypospadias and chordee. Genetic testing for 46,XY DSD revealed a novel, dominant, heterozygous, likely pathogenic variant (c.102 + 1G &gt; C) in the NR5A1 gene associated with severe phenotype of undervirilized male. This case illustrates the crucial role of molecular genetic testing for the diagnosis of 46,XY DSDs and a novel NR5A1 gene variant.
Robert Frost: Rhythmical Structure of His Iambic Tetrameter
Authors: Tarlinskaja Marina 
Published: September 2023

Abstract
This essay researches how Robert Frost's poems “are made.” It offers new methodologies of analyzing stressing, the main constituent of poetic rhythm. Frost's iambic tetrameter is the material of analysis. The formula of entropy is used to measure the rhythmical diversity of texts. The essay also follows the distribution of word boundaries and syntactic breaks in poetic texts. Word boundaries and syntactic breaks are two more constituents of poetic rhythm. The conclusions are: (1) Frost's late poems are rhythmically more diverse than his early poems, and (2) the rhythmical structure of lines also depends on the narrative and thematic features of the poems. Similar features had been discovered in Russian poetry. Further research might show if these are poetic universals.
What Rhymes withMisogyny? Rossetti, Dickinson, and Plath at Rhyme's Limit
Authors: Townsend Chris 
Published: September 2023

AbstractHistorical poetics often seeks to read “from the inside out,” to understand form's history by starting with the features of form themselves. In that sense, it is uniquely placed to understand the intersections of poetics and politics, and to uncover the places where rhythmic features intersect with issues of power. This essay shows that one particular feature of form—terminal rhyme—has had a peculiar and troubling closeness to strains of critical misogyny: on the one hand, rhyme is sometimes deemed “unmanly” or unserious, yet there is also a history of maligning women poets for being bad rhymers, and not feminine enough. Beginning with what may seem like the opposite school to historical poetics—the contextless “Practical Criticism” exercises of New Criticism—it makes the case for a close attention to rhyme types and rhyme practices within politically aware critical reading and explores unorthodox approaches to rhyme in three exemplary poets: Christina Rossetti, Emily Dickinson, and Sylvia Plath.
“The Utter Blankness Found Within”: Epigenetic Formalism in House of Leaves
Authors: Martinson T. J. 
Published: September 2023

Abstract
This article examines epigenetic relations through the study of “blankness” in Mark Z. Danielewski's House of Leaves (2000). The novel's experimental form, as well as the eponymous House on Ash Tree Lane, provide particularly productive models for envisioning the structural and mutative agency of immaterial relations responsible for epigenesis, or the molecular signals that alter genetic expression. To examine the agency of blankness as it applies across literary theory and epigenesis, this essay borrows from science studies, new materialisms, biosemiotics, new formalisms, and Derridean deconstruction to offer an interdisciplinary hermeneutics deemed “epigenetic formalism” by which to better conceive of a network—whether biological or literary—whose form absorbs its environmental milieu via the agency of blankness. In this way, examining epigenesis alongside House of Leaves allows for crucial insight into the relationality and formal composition of the human genome, as well as insight into the relationality and composition of forms in a literary text.
Barriers to and facilitators for the creation, dissemination, implementation, monitoring, and evaluation of oral health policies in the WHO Africa region: A scoping review protocol
Authors: Carrasco-Labra Alonso , Verdugo-Paiva Francisca , Matanhire-Zihanzu Cleopatra N. , Booth Emmett , Kohler Iliana V. , Urquhart Olivia , Makino Yuka , Glick Michael 
Published: September 2023

Background: Evidence-informed oral health policies (OHP) can be instrumental in ending the neglect of oral health globally. When appropriately developed and implemented, OHP can improve the efficiency of healthcare systems and the quality of health outcomes. However, more than half of the countries in the World Health Organization (WHO) African region did not have an oral health policy or even the existence of a policy in need of additional and more national-specific OHP as part of non-communicable diseases and universal health coverage agendas. The objective of this protocol’s study is to determine the barriers to and facilitators for the creation, dissemination, implementation, monitoring, and evaluation of OHP in the WHO Africa region. Methods: We will conduct a systematic search in Global Health, Embase, PubMed, PAIS, ABI/Inform, Web of Science, Academic Search Complete, Scopus, databases that index gray literature, and the WHO policy repositories. We will include qualitative, quantitative, or mixed-methods research studies and OHP documents published since January 1, 2002, which address stakeholders' perceptions and experiences regarding barriers to and facilitators for the creation, dissemination, implementation, monitoring, and evaluation of OHP in countries part of the WHO African region. We will produce descriptive statistics (frequencies and proportions) for quantitative data and conduct descriptive content analysis for qualitative data. Discussion: To effectively establish evidence-based OHP in the WHO African region, it is crucial to recognize existing challenges and opportunities for progress. The findings of this review will be relevant for Chief Dental Officers at ministries of health, administrators of dental schools, or academic institutions in the WHO African region and will inform a stakeholder dialogue meeting in Kenya in November of 2023. Registration: Open Science Framework: https://doi.org/10.17605/OSF.IO/9KMWR
Effect of atorvastatin on subclinical atherosclerosis in virally-suppressed HIV-infected patients with CMV seropositivity: a randomized double-blind placebo-controlled trial
Authors: Yunihastuti Evy , Rusdi Lusiani , Syahrir Azizi Muhammad , Estiasari Riwanti , Jasirwan Chyntia Olivia Maurine , Wulandari Endah Ayu T. , Purnamasari Dyah , Shinta Noviar Mutiara , Aman Nasution Sally 
Published: September 2023

Background: Persistent immune activation and inflammation in HIV-infection are linked to excess cardiovascular risk and other non-communicable diseases. Periodic asymptomatic CMV-reactivity in HIV infected patients over a lifetime may contribute to non-AIDS defining morbidity. Despite undetectable levels of HIV and CMV, these patients continue to have increased levels of biomarkers and immune activations. Statin administration is thought to reduce subclinical atherosclerosis by decreasing LDL-C levels. It may also add beneficial effects against CMV infection. Methods: We are conducting a double-blind placebo-controlled trial in which patients are randomized to receive either atorvastatin or placebo with a ratio of 1:1. This trial aims to study the effect of atorvastatin in statin-naive virally-suppressed HIV-infected patients with stable ART and CMV seropositivity on carotid intima media thickness (CIMT), tool that evaluates subclinical atherosclerosis. The study recruits 80 patients at HIV integrated care unit of Cipto Mangunkusumo hospital. All eligible subjects have CIMT evaluation as primary outcome, along with flow mediated vasodilatation (FMD), liver fibrosis and steatosis evaluation, fasting lipid, neurocognitive test, community periodontal index (CPI), and residual immune activation as secondary outcomes in 48 weeks. Ethics and dissemination: This study has received an ethical approval from Health Research Ethics Commitee–Universitas Indonesia and Cipto Mangunkusumo Hospital. Before joining the study, all participants fill in an informed consent form. At the end of study analysis, the trial results will be published and disseminated in peer-reviewed journals. Discussion: The main purpose of our study is to evaluate the effect of atorvastatin administration on CIMT changes in statin naïve virally suppressed HIV-infected patients with stable ART and CMV seropositivity Registration: ClinicalTrials.gov ID NCT04101136; registered on 24 September 2019.
Fluorescent reporter of Caenorhabditis elegans Parkin: Regulators of its abundance and role in autophagy-lysosomal dynamics
Authors: Vozdek Roman , Wang Bingying , Li Kathy H. , Pramstaller Peter P. , Hicks Andrew A. , Ma Dengke K. 
Published: September 2023

Background: Parkin, which when mutated leads to early-onset Parkinson’s disease, acts as an E3 ubiquitin ligase. How Parkin is regulated for selective protein and organelle targeting is not well understood. Here, we used protein interactor and genetic screens in Caenorhabditis elegans (C. elegans) to identify new regulators of Parkin abundance and showed their impact on autophagy-lysosomal dynamics and alpha-Synuclein processing. Methods: We generated a transgene encoding mCherry-tagged C. elegans Parkin – Parkinson’s Disease Related 1 (PDR-1). We performed protein interactor screen using Co-immunoprecipitation followed by mass spectrometry analysis to identify putative interacting partners of PDR-1. Ribonucleic acid interference (RNAi) screen and an unbiased mutagenesis screen were used to identify genes regulating PDR-1 abundance. Confocal microscopy was used for the identification of the subcellular localization of PDR-1 and alpha-Synuclein processing. Results: We show that the mCherry::pdr-1 transgene rescues the mitochondrial phenotype of pdr-1 mutants and that the expressed PDR-1 reporter is localized in the cytosol with enriched compartmentalization in the autophagy-lysosomal system. We determined that the transgenic overexpression of the PDR-1 reporter, due to inactivated small interfering RNA (siRNA) generation pathway, disrupts autophagy-lysosomal dynamics. From the RNAi screen of putative PDR-1 interactors we found that the inactivated Adenine Nucleotide Translocator ant-1.1/hANT, or hybrid ubiquitin genes ubq-2/hUBA52 and ubl-1/hRPS27A encoding a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively, induced PDR-1 abundance and affected lysosomal dynamics. In addition, we demonstrate that the abundant PDR-1 plays a role in alpha-Synuclein processing. Conclusions: These data show that the abundant reporter of C. elegans Parkin affects the autophagy-lysosomal system together with alpha-Synuclein processing which can help in understanding the pathology in Parkin-related diseases.
Statistical analysis plan for the Petal trial: the effects of parental touch on relieving acute procedural pain in neonates
Authors: Baxter Luke , Hauck Annalisa G.V. , Bhatt Aomesh , Cobo Maria M. , Hartley Caroline , Marchant Simon , Poorun Ravi , van der Vaart Marianne , Slater Rebeccah 
Published: September 2023

Background: Infants undergo multiple clinically-required painful procedures during their time in hospital, and there is an increasing desire from both parents and clinical staff to have parents directly involved in their newborn’s pain relief. The Petal trial is a multicentre randomised controlled trial to investigate the effect of parental touch prior to a clinically-required heel lance on neonatal pain responses and parental anxiety. To avoid biases due to selective analysis and reporting, a clinical trial’s statistical analysis plan (SAP) should be finalised and registered prior to dataset lock and unblinding. Here, we outline the SAP for the Petal trial, which was registered on the ISRCTN registry prior to dataset lock and unblinding. The SAP is written in line with best practice guidelines to provide sufficient detail for reproducibility. Methods: The primary outcome is the neonate’s brain activity recorded using electroencephalography (EEG) in response to a heel lance blood sampling procedure. In this superiority trial, the primary objective is to investigate the potential efficacy of a parent-led non-pharmacological analgesic intervention on reducing the magnitude of neonates’ noxious stimulus-evoked brain activity. Secondary outcomes include neonatal clinical pain scores and tachycardia, and parental anxiety. Conclusions: Paediatric pain trials have been highlighted by regulatory bodies as an important and challenging topic, with interest increasing in brain imaging outcomes. The Petal trial, to which this SAP relates, is part of a larger effort of establishing a brain-based EEG outcome measure of infant pain for use in clinical trials. This SAP is thus likely to be of interest to those in academia, pharmaceutical companies, and regulatory bodies. We hope this SAP will help establish a foundation for the use of brain imaging outcomes in neonatal pain clinical trials, on which best practices can be built. Trial registration: ClinicalTrials.gov: NCT04901611, 25/05/2021; ISRCTN: ISRCTN14135962, 23/08/2021).
Liaisons fructueuses : théories des sémioticiens français comme source d’inspiration pour les chercheurs polonais en traduction intersémiotique
Authors: Stodolna Aleksandra 
Published: September 2023

FRUCTUOUS LIAISONS: THEORIES OF FRENCH SEMIOTICIANS AS A SOURCE OF INSPIRATION FOR POLISH RESEARCHERS IN INTERSEMIOTIC TRANSLATION
Today, reflection on film adaptation and intersemiotic translation oscillates between two extremes: “one-off” analyses of concrete works on the one hand, and global reflection on the multimodal nature of new media, on the other. From this perspective, intersemioticity is conceived as a quality “hidden” in every text, including those with no other codes than the verbal code; in such cases, adapting the text to other media “reveals” its intrinsic intersemiotic potential. But in following this new path, scholars have moved away from the original aim of the French Semiotics: to prove that Jakobson was right in declaring that intersemiotic translation is a process that can be compared to interlinguistic translation, that the former is subject to the same rules as the latter and, consequently, that transmutation can be analyzed using the methods and tools originally created for interlinguistic translation. There is, however, a group of Polish researchers who have carried out, and continue to carry out, in-depth research into the problem of “adaptation-as-translation”. In this article, I shall attempt to outline the impact that French theory (first filmological, then semiotic and semiological) has had on intersemiotic translation research (by authors publishing both in French and in Polish); my second aim is to familiarize French-speaking readers with the “Polish school’s” theories of adaptation-as-translation, especially those of Seweryna Wysłouch, and their potential to promote and deepen reflection on the language of film and intersemiotic translation.
Eliciting Informative Priors by Modeling Expert Decision Making
Authors: Falconer Julia R. , Frank Eibe , Polaschek Devon L. L. , Joshi Chaitanya 
Published: September 2023

There are significant limitations to current methods for eliciting the prior beliefs of experts. To combat some of these limitations, this paper proposes an alternative approach that infers an expert’s prior beliefs about an uncertain event, A, from the expert’s past decisions. We show that an analyst can use past information on an expert’s decision-making task, contingent on an expert’s prior of A, to model the decision-making process and infer an approximation of the prior for A. This concept is illustrated by an application to recidivism. We conclude this work by highlighting important directions for future research.Funding: J. R. Falconer’s research is funded through the University of Waikato Doctoral Scholarship.
Coherent Fourier scatterometry: a holistic tool for inspection of isolated particles or defects on gratings
Authors: Paul Anubhav , Kolenov Dmytro , Scholte Thomas , Pereira Silvania F. 
Published: September 2023

Detecting defects on diffraction gratings is crucial for ensuring their performance and reliability. Practical detection of these defects poses challenges due to their subtle nature. We perform numerical investigations and demonstrate experimentally the capability of coherent Fourier scatterometry (CFS) to detect particles as small as 100 nm and also other irregularities that are encountered usually on diffraction gratings. Our findings indicate that CFS is a viable tool for inspection of diffraction gratings.