bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection and full-genotype characterization of rare and reassortant Rotavirus A strains in Nizhny Novgorod, European part of Russia
Authors: Sashina Tatiana A. , Velikzhanina Elena I. , Morozova Olga V. , Epifanova Natalia V. , Novikova Nadezhda A. 
Published: March 2023

Abstract
Reassortant DS-1-like Rotavirus A strains have been shown to widely circulate in many countries around the world. In Russia, the real contribution of such strains remains unclear due to preferred use of the traditional binary classification only. In this work, we obtained data on partial sequencing of all 11 genome segments and presented the full-genotype constellations of rare and reassortant rotaviruses circulating in Nizhny Novgorod in 2016-2019. DS-1-like G3P[8] and G8P[8] strains were found, and it emphasized the global trend. Most likely, they were introduced into the territory of Russia from other countries, but subsequently underwent further evolutionary changes locally. G3P[8], G9P[8], and G12P[8] Wa-like strains withunusual for the territory of Russia subgenotypic lineages were also identified. Reassortant G2P[8], G4P[4], and G9P[4] strains with one Wa-like gene (VP4 or VP7) on a DS-1-like backbone were found and apparently had alocal origin. Feline-like G3P[9] and G6P[9] strains were phylogenetically close to BA222 isolated from Italian cat but carried some traces of reassortment with human strains from Russia and other countries. Thus, full-genotype investigation of Nizhny Novgorod Rotavirus A strains clarified some questions related to their origin and evolution.
Family Connections in the treatment of relatives of people with eating disorders and personality disorders: Study protocol of a randomized control trial
Authors: Guillén Verónica , Arnal Antonio , Pérez Sandra , García-Alandete Joaquín , Fernandez-Felipe Isabel , Grau Antoni , Botella Cristina , Marco José Heliodoro 
Published: March 2023

Abstract
Background: Eating disorders (EDs) are serious disorders that significantly affect not only the lives of patients, but also those of their family members who often experience high levels of burden, suffering and helplessness. If, in addition to ED, the patient has a personality disorder (PD), the psychological distress experienced by family members can be devastating. However, few treatments have been developed for family members of people with ED and PD.
Family Connections (FC) is a programme that has been shown to be effective for family members of people with borderline personality disorder. The overall aims of this work are: (a) to adapt FC for application to family members of patients with BPD-PD (FC: ED-PD); (b) to analyse, in a randomised controlled clinical trial, the efficacy of this programme in a Spanish population, compared to a control condition consisting of treatment as usual optimised treatment (TAU-O); (c) to analyse the feasibility of the intervention protocol; (d) to analyse whether the changes that may occur in relatives are related to improvements in the family climate and/or improvements observed in patients; and (e) to analyse the perceptions and opinions of relatives and patients about the two intervention protocols.
Methods: The study uses a two-arm randomised controlled clinical trial with two experimental conditions: adaptation of FC programme (FC: ED-PD) or Treatment as usual optimised (TAU-O). Participants will be family members of patients who meet DSM-5 criteria for ED and PD or dysfunctional personality traits. Participants will be assessed before and after treatment and at one-year follow-up. The intention-to-treat principle will be used when analysing the data.
Discussion: The results obtained are expected to confirm the effectiveness of the programme and its good acceptance by family members.
Trial registration: ClinicalTrials.gov Identifier: NCT05404035. Accepted: May 2022.
A Random Optical Parametric Oscillator
Authors: Tovar Pedro , Weid Jean Pierre von der , Wang Yuan , Chen Liang , Bao Xiaoyi 
Published: March 2023

Abstract
Optical parametric oscillators provide short coherent light pulses at widely tunable wavelengths. Their primary drawback is the requirement of precise cavity control, making such devices specially challenging to develop in long cavities, and with oscillation limited to a fixed repetition rate. Herein, exploiting the inherent disorder of the refractive index in single-mode fibres we developed the first random optical parametric oscillator - the parametric analogous of random lasers. Parametric amplification is provided by modulation instability through the Χ(3) non-linearity and feedback is given by Rayleigh scattering. The system is realised in a pulsed configuration, with extremely small (<0.001%) feedback. To enhance the weak feedback, a novel piecewise distributed random cavity is demonstrated. In contrast to conventional parametric oscillators, the emission is sustained at arbitrary rates and dispensing any kind of cavity control loop, resulting in a far more versatile device, representing an important step toward the development of stable and tunable - both in wavelength and repetition rate - parametric oscillators. The ultra-long cavity used in experiments (~5km) enabled the generation of four-wave mixing products between the pump and the singly-resonant oscillator, giving rise to a train of picosecond-pulses, which would find applications in ultra-fast optics.
Data simulation of optimal model for numerical solution of differential equations based on deep learning and genetic algorithm
Authors: Jing Li 
Published: March 2023

Abstract
Calculus equation is an important tool for mathematical research and plays an important role in most natural science research. Since the beginning of the 18th century, people have gradually used differential and integral equations to solve physical problems. In general, several different aspects of differential equations in the field of mathematics are concerned and studied by most scholars. However, this paper studies and establishes the optimal model for numerical solution of differential equations through deep learning and genetic algorithm. In this paper, the solution of ordinary differential equations is solved through the use of polynomial function space, while the linear combination of simple function x and its product nx can obtain multinomial function space. The space function form of polynomial is very simple, and the operation ability is very strong. Almost all functions can be approximated, and the function space can be transformed by a simple function. Through data simulation test results, it can be found that the oscillation of neural network output is stronger and stronger with the increase of depth, that is to say, the deeper depth endows the neural network with stronger oscillation properties, so for the oscillation function, the depth neural network fitting effect is better than the shallow neural network. Therefore, by combining deep learning and genetic algorithm, this paper studies and establishes the optimal model for numerical solution of differential equations, and finds that the deep neural network can largely complete data simulation.
Treatment of Type Ⅱ Symptomatic Ulnar Styloid Nonunions with the Reinsertion of the Triangular Fibrocartilage Complex
Authors: Yu Xiaofei , Yu Yadong , Zhang Xu , Li Jia , Zhou Tong , Chen Huan 
Published: March 2023

Abstract
Purpose
The purpose of this retrospective study was to introduce an alternative technique for the treatment of type II symptomatic ulnar styloid nonunion by the reinsertion of the triangular fibrocartilage complex and the ulnar collateral ligament.
Methods
Between March 2009 and May 2017, 45 patients (34 males and 11 females) suffering from the nonunion of type II ulnar styloid fractures all underwent the subperiosteal resection of the avulsed fragments and the reinsertion of the TFCC and ulnar collateral ligament. Outcome assessments included the ranges of motion of the wrist, grip strength, pain, and Mayo wrist score. The preoperative and postoperative parameters were compared. A P-value less than 0.05 was considered to be statistically significant.
Result
The mean follow-up period was 21.66 ± 7.93 months (range, 12 to 26 months). At the final follow-up, the mean preoperative flexion and extension were 79.32 ± 4.52° and 74.40 ± 4.36° respectively. The mean preoperative pain score, grip strength, Mayo wrist score were 32.48 ± 4.00; 23.88 ± 8.38 kg, and 77.72 ± 8.31 respectively. The mean postoperative flexion and extension of the wrist were 80.56 ± 6.32° and 75.43 ± 3.12° respectively. The mean postoperative pain score, grip strength, and Mayo wrist score were 12.41 ± 3.27, 26.31 ± 8.30 kg, and 90.71 ± 7.97 respectively. There were significant differences with respect to pain, grip strength, and Mayo wrist score (P < 0.05), but no significant differences concerning the range of motion of the wrist.
Conclusion
In the treatment of the nonunion of type II ulnar styloid fractures, the resection of the avulsed fragments followed by the reinsertion of the TFCC and the ulnar collateral ligament with an anchor was a reliable alternative technique, bringing the satisfactory function of the wrist.
Reducing Pain and Discomfort Associated with Rubber Dam Clamp Placement in Children: A Systematic Review and Meta-Analysis of Effectiveness
Authors: Afshari Elham , Sabbagh Sedigheh , Khorakian Fatemeh , Shirazi Alireza Sarraf , Baghban Alireza Akbarzadeh 
Published: March 2023

Abstract

Background The application of rubber dams is a widely accepted method of tooth isolation in dental practice. Placement of the rubber dam clamp might be associated with levels of pain and discomfort, especially in younger patients. The purpose of the present study is to systematically review and meta-analyze the efficacy of the proposed methods for reducing pain and discomfort associated with rubber dam clamp placement in children. Materials and Methods English-language literature from inception until September 6th, 2022 was searched in MEDLINE (via PubMed), SCOPUS, Web of Science, Cochrane, EMBASE, and ProQuest Dissertations & Theses Database Global for articles. Randomized controlled trials (RCTs) were retrieved and risk of bias assessment was performed. Studies were summarized and pooled estimates of pain intensity scores and incidence of pain were calculated. The meta-analysis was conducted in four comparison groups. Results Initially, 1452 articles were retrieved. Sixteen RCTs were finally included for reviewing and summarizing. Nine articles were included for quantitative meta-analysis. The differences in pain intensity scores were not significant in any comparison groups. Eight studies were judged as having some concern for risk of bias and the remaining studies were considered as low risk for bias. Conclusion Within the limitations of the current study, no significant differences were found between the proposed methods for reducing pain and discomfort associated with rubber dam clamp placement in children. A larger number of more homogenous studies regarding intervention methods and pain assessment tools need to be conducted in order to draw stronger conclusions.
A tale of two hospitals: comparing CAPA infections in two ICUs during the Spanish fourth pandemic wave.
Authors: Castellano Miguel Angel Sanchez , Marcelo Cristina , Marco Javier , Figueira-Iglesias Juan Carlos , García-Rodríguez Julio 
Published: March 2023

Abstract
Purpose: COVID-19 associated pulmonary aspergillosis (CAPA) is a new clinical entity linked to SARS-CoV-2 infection that is causing a rise on the risk of complications and mortality, particularly in critical patients.
Methods: We compared diagnostic and clinical features in two cohorts of patients with severe COVID-19 admitted in the intensive care units (ICU) of two different hospitals in Madrid, Spain, between February and June 2021.
Results: Cultures were positive for Aspergillus spp. in 32 patients. According to 2020 European Confederation of Medical Mycology and the International Society for Human and Animal Mycology (ECMM/ISHAM) consensus, 11 patients were diagnosed with possible CAPA and 10 patients with probable CAPA. Global incidence for CAPA was 6.3%. Global median days between ICU admission and diagnosis was 12 days. Aspergillus fumigatuscomplex was the main isolated species. Antifungal therapy was used in 75% of patients with CAPA suspicion, with inter-hospital differences in the administered antifungals. Global overall mortality rate was 66.6% (14/21).
Conclusions: There were no significant differences in incidence between the two hospitals, and differences in antifungal therapy did not correlate with differences in mortality, reflecting that both first-line azoles and Amphotericin B could be effective in treating CAPA infections, according to the current guideline indications.
Characterization of non-conventional pollutants (BTEX) in air by means of chemometrics techniques
Authors: Sánchez-Andica Rubén Albeiro , Salas-Chávez Wilson Rafael , Páez-Melo Martha Isabel 
Published: March 2023

Abstract
In this work, chemometric and spatial interpolation methods were used to characterize non-conventional pollutants in the atmosphere of the city of Santiago de Cali (Colombia), The contaminants were monitored using passive diffusion samplers during two (2) periods (January to February and March to April) in two consecutive years before the pandemic (2020). None of the cases exceeded the concentration limits established by the National Air Quality Standard. The Cluster analysis allowed evidencing the existence of groups, which correspond to low, medium and high influence sites of the pollutants. The Principal Components Analysis (PCA) led to gathered all the variables in two constituents: the first one (PC1) could be related as an indicator of pollutant mobile sources due to the similar contribution of pollutants, while the second one (PC2) as an indicator for punctual emissions of toluene, as it was the one that contributed the most. The performance of the spatial analysis drove to identify the downtown and north of the city as areas of high-influence of PC1, at the same time, a substantial decrease in its effects to the periphery, particularly towards the south. On the other hand, with the Inverse Distance Weighting (IDW) it was possible to observe the hot-spots of both PCs, particularly real estate construction areas and the downtown industrial sector of the city. Finally, it was found a cancer risk in downtown and north-eastern areas of the city, related to the exposure to benzene and ethylbenzene; observation that coincide in the area of incidence of PC1.
Escape of a particle from two-dimensional potential well
Authors: Engel Amit , Gendelman Oleg , Fidlin Alexander 
Published: March 2023

Abstract
The paper addresses the escape of a classical particle from a two-dimensional potential well. The main goal is to explore the escape basin and to formulate the analytic prediction of the stability region in the space of initial conditions. To this point, an appropriate modification of the isolated resonance approximation is developed. The approach provides an outer boundary for the stability basin. The mechanism of erosion of the predicted stability boundary via the secondary resonance is explored numerically.
Characterization and Dielectric Properties of Flexible PVDF/LiZnVO 4 nanocomposites for High-Performance Lithium-ion Battery Applications
Authors: Elashmawi I. S. , Ismail A. M. , Abdelghany A. M. , Yassin A. 
Published: March 2023

Abstract
Thin polymeric films of Poly(vinylidene fluoride) (PVDF) containing variable mass fractions of LiZnVO4 nanoparticles (LZV-NPs) were successfully synthesized via the ordinary solution casting route. X-ray diffraction (XRD), Fourier transform infrared (FT-IR), and ultraviolet-visible spectroscopy was used to explore the role of LZV-NPs on the structural and optical characteristics of synthesized nanocomposites. In addition, AC conductivity was investigated. The XRD spectral data reveals the crystalline nature of LZV-NPs with rhombohedral structure with an average size of 83 nm calculated using Scherer's equation. The interaction between PVDF and LiZnVO4 was approved through the shift in characteristic FT-IR bands. The decrease in band gap energies with increasing LiZnVO4 is attributed to the change of density in the localized states within the PVDF. The effect of both frequency and temperature on the AC parameters was also investigated. Both ε' and ε" had their maximum values at low frequencies and decreased as the frequency and temperature increased. The XRD and FT-IR findings were correlated with the change in dielectric characteristics at 5 wt. percent LiZnVO4, suggesting their potential use as a basic material for developing cutting-edge energy storage devices and lithium-ion batteries.
Targeting Ferroptosis Promotes Functional Recovery Through Mitigating White Matter Injury Following Acute Carbon Monoxide Poisoning
Authors: Wang ShuHong , Xiong Binyuan , Tian Yin , Hu Quan , Jiang Xuheng , Zhang Ji , Chen Lin , Wang Ruilie , Li Mo , Zhou Xin , Zhang Tianxi , Ge Hongfei , Yu Anyong 
Published: March 2023

Abstract
Survivors suffering from acute carbon monoxide poisoning (ACMP) are apt to develop white matter injury (WMI). While, the mechanism that ACMP evokes WMI remains unclear. Given that ferroptosis plays an evident role in igniting oligodendrocyte damage to deteriorate WMI, exploring regimens to attenuate ferroptosis is a feasible approach to alleviate WMI post-ACMP. Here, the results indicated that ACMP induced WMI to evoke motor impairment resulting from the surplus iron and reactive oxygen species (ROS) accumulation after ACMP. And, the administration of ferrostatin-1 reduced iron and ROS deposition to repress ferroptosis, thereafter reducing WMI to promote motor recovery. Furthermore, the result demonstrated that the nuclear factor erythroid-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway was involved in attenuating ferroptosis resulting from the application of ferrostatin-1. The present study offers a rationale that targeting ferroptosis to alleviate WMI is a feasible therapeutic strategy for ACMP.
NIR-Hyperspectral camera Analyses for differencing Agroforestry and Forestry Poplar Woods.
Authors: Heim Lucie , Brancheriau Loïc , Marchal Remy , Boutahar Nabila , Denaud Louis , Badel Eric , Meghar Karima , Candelier Kevin 
Published: March 2023

Abstract
Wood characteristics of trees grown in agroforestry systems are still little studied, while their growth conditions are different from conventional stands. This work focused on the impact of the agroforestry system on the lignin/cellulose ratio of hybrid poplar trees. One disk sample was harvested on 6 agroforestry (AF) and 6 forest control (FC) poplar trees, at breast height ground level (1.30m). Every disk was analyzed by NIR-Hyperspectral imaging using a Specim FX17 (Specim, Spectral Imaging Ltd.). Images from hyperspectral camera analyses corresponding to absorbance spectra were collected at the wavelength of 1450 nm, attributed to first overtone O-H stretching vibration of lignin/extractives compounds, in order to clearly observe the chemical difference between AF and FC poplar woods. The results indicated significant difference between the chemical composition, based on estimated lignin content, of AF and FC poplar woods. The lignin content appeared to be lower in AF poplar wood than in FC poplar wood. These results could be explained by the different tree growing conditions between the both systems. AF poplar tended to produce more tension wood and more juvenile wood than FC poplar, which resulted in a lower concentration in lignin.
The diagnostic accuracy of lung ultrasound to determine PiCCO-derived extravascular lung water in invasively ventilated patients with COVID-19 ARDS
Authors: Atmowihardjo Leila N. , Schippers Job R. , Haaksma Mark E. , Smit Marry R. , Bogaard Harm J. , Heunks Leo , Juffermans Nicole P. , Schultz Marcus J. , Endeman Henrik , Velzen Patricia van , Tuinman Pieter R. , Aman Jurjan , Bos Lieuwe D. J. 
Published: March 2023

Abstract
Background: Lung ultrasound (LUS) is a non-invasive method to detect and quantify pulmonary edema. However, it remains uncertain how components of the LUS examination should be aggregated into a score for quantifying pulmonary edema. We examined the diagnostic accuracy of various LUS scores with the extravascular lung water index (EVLWi) assessed with PiCCO in patients with moderate-to-severe COVID-19 ARDS.
Methods: In this predefined secondary analysis of a multicenter randomized-controlled trial (InventCOVID), patients were included within 48h after intubation and underwent LUS and EVLWi measurement at two time points (first and fourth study day). EVLWi and ∆EVLWi were used as reference standard. Two 12-region scores (global LUS and LUS-ARDS), an 8-region anterior-lateral score and a 4-region B-line score were used as index tests. Pearson correlation was performed and the area under the receiver operating characteristics curve (AUROCC) for severe pulmonary edema (EVLWi>15mL/kg) was calculated.
Results: 26 of 30 patients (87%) had complete LUS and EVLWi measurements at time point 1 and 24 of 29 patients (83%) at time point 2. The global LUS (r=0.54), LUS-ARDS (r=0.58) and anterior-lateral score (r=0.54) were significantly correlated with EVLWi, while the B-line score was not (r=0.32). ∆global LUS (r=0.49) and ∆anterior-lateral LUS (r=0.52) were significantly correlated with ∆EVLWi, while correlation of ∆LUS-ARDS (r=0.43) and ∆B-lines (r=0.32) did not reach statistical significance. AUROCC for EVLWi>15ml/kg was 0.73 for the global LUS, 0.79 for the anterior-lateral and 0.85 for the LUS-ARDS score.
Conclusions: The global LUS, LUS-ARDS and antero-lateral score can quantify PiCCO-derived pulmonary edema measurements in COVID-19 ARDS. The LUS-ARDS score showed the highest diagnostic accuracy for severe pulmonary edema.
Trial registration: ClinicalTrials.gov identifier NCT04794088, registered on 11 March 2021. European Clinical Trials Database number 2020-005447-23.
Alksite – based material to restore endodontically treated teeth: A randomized controlled clinical trial
Authors: Bepu Davi , Franco Natalia , Souza-Gabriel Aline , Corona Silmara , Sanchez Luiza 
Published: March 2023

Abstract
Objectives
The aim of this study was evaluated longitudinally evaluate, after a 6-months period, the clinical performance of an alkasit- based material (Cention N, Ivoclar) in molars with root canal treatment.
Methods
The project was registered in the Brazilian Registry of Clinical Trials – REBEC (RBR-97kx5jv) on 19/01/2023. This randomized clinical trial that included 33 patients with an endodontically treated mandibular molar requiring restoration. Patients were randomly assigned according to the restorative treatment: control: restoration with Bulk-fill resin (Ivoclar - n = 17) and restoration with alkasite-based material (Ivoclar - n = 16). A self-etching adhesive was applied. Three calibrated professionals used the United States Public Health Service (USPHS) criteria to evaluate retention, secondary caries, marginal adaptation, restoration color, marginal pigmentation, and anatomical shape at seven days (baseline) and six months. The radiographic analysis assessed the presence of a radiolucent line adjacent to the restoration, the lack or excess of the material, contact point, and caries recurrence in both periods. Data were analyzed by Friedman, Kruskall-Walis, and Wilcoxon tests (α = 0.05).
Results
After 6 months of follow up, the Alksite-based demonstrated greater wear of the anatomical shape (p = 0.022), and a greater color difference compared to natural tooth (p = 0.0332), both with a statistically significant difference. All other criteria did not show significant differences between the materials or the analysis periods.
Conclusion
The use of Alkasite-based material on endodontically treated teeth influenced the color and anatomical shape performance, however did not influence the longevity and success of the composite restorations after six months.
Clinical Relevance
Alkasite Based material may be an alternative for the restoration of endodontically treated teeth