bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy – active Phytochemicals and In Vivo Molecular Targets
Authors: Lü Junxuan , Jiang Cheng , Drabick Joseph J. , Joshi Monika , Perimbeti Stuthi 
Published: January 2025

Abstract

Angelica
gigas Nakai (AGN) root is a medicinal herbal widely used in traditional medicine in Korea. AGN root ethanolic extracts have been marketed as dietary supplements in the United States for memory health and pain management. We have recently reviewed the pharmacokinetics (PK) and first-pass hepatic metabolism of ingested AGN supplements in humans for the signature pyranocoumarins decursin (D, C

max
1x), decursinol angelate (DA, C

max
~ 10x) and their common botanical precursor and hepatic metabolite decursinol (DOH, C

max
~ 1000x). Here we update in vivo medicinal activities of AGN and/or its pyranocoumarins and furanocoumarin nodakenin in cancer, pain, memory loss, cerebral ischemia reperfusion stroke, metabolic syndrome and vascular endothelial dysfunctions, anxiety, sleep disorder, epilepsy, inflammatory bowel disease, osteoporosis and osteoarthritis. Given their polypharmacology nature, the pertinent mechanisms of action are likely misrepresented by many cell culture studies that did not consider the drug metabolism knowledge. We report here Rho-associated protein kinases (ROCK1/2) as novel targets for DA and DOH. Combining with published inhibitory activity of DOH on acetylcholinesterase, agonist activity of DOH and antagonist/degrader activity of DA/D on androgen and estrogen receptors, D/DA promoting activity for glutamic acid decarboxylase (GAD)- gamma-aminobutyric acid (GABA) inhibitory axis and inhibition of glutamate dehydrogenase (GDH), monoamine oxidase-A (MAO-A) and transient receptor potential vanilloid 1 (TRPV1), we postulate their contributions to neuro-cognitive, metabolic, oncologic, vascular and other beneficial bioactivities of AGN extracts. A clinical trial is being planned for an AGN extract to manage side effects of androgen deprivation therapy in prostate cancer patients.
Molecular detection of the zoonotic trematode Centrocestus formosanus (Nishigori, 1924) (Opisthorchiida, Heterophyidae) in Central Europe
Authors: Šmiga Ľubomír , Šmigová Júlia , Berrilli Federica , Papajová Ingrid , Lazár Peter , Guadano-Procesi Isabel 
Published: January 2025

AbstractIn our study, fancy southern platyfish Xiphophorus maculatus (Cyprinodontiformes, Poeciliidae) were examined due to breathing disorders and mortality. Fish came from Vietnam farm and were redistributed by international wholesaler. In fish, loss of appetite and gasping near the water surface was observed. Gill tissue showed small white spots, caused by metacercariae and areas of clearing surrounding the cysts. Primary branchial filaments were hyperplastic, necrotic, significantly deformed and shortened. Samples were fixed in 98% alcohol for molecular analyses. The identity of C. formosanus (Opisthorchiida: Heterophyidae) was confirmed by molecular methods (GenBank accession number OP808358). In this study, we present the first report of C. formosanus in Central Europe. Uncontrolled transport of fish can lead to health and economic concerns, including the transmission of zoonotic pathogens to non-native ecosystems.
Optimized Removal of Cr (VI) and Ni (II) From Wastewater Using Corncob-Derived Activated Carbon
Authors: Kamel Moatasem , Bastaweesy Ali M. , Hefny Rasha A. 
Published: January 2025

Abstract
This research explores the potential of activated carbon (AC), produced from corncobs, for eliminating dissolved hexavalent chromium and divalent nickel. SEM analysis revealed a rough, textured surface on the corncob-derived activated carbon with well-defined pores and crevices, indicating the successful formation of activated carbon. We employed X-ray diffraction to confirm the presence of crystalline graphite within the carbon structure, suggesting effective alignment of carbon atoms. Utilizing Design of Experiments (DOE), we optimized adsorption conditions for enhanced removal efficiency. Our findings reveal that under optimized conditions, the activated carbon achieved a maximum removal of 99.2% for Chromium (VI) at 105 min, pH 2, temperature of 37°C, an initial chromium concentration of 37.2 ppm, and an AC dosage of 0.289 g. Similarly, Nickel (II) removal reached 98.7% at pH 12, temperature of 40°C, a starting concentration of 31 ppm, and an adsorbent amount of 0.94 g. The adsorption kinetics of both metals followed a pseudo-second-order mechanism, suggesting chemisorption as the controlling mechanism. The adsorption data was best described by the Langmuir isotherm, indicating a monolayer coverage of metal ions on the adsorbent surface. These results demonstrate the potential of corncob-derived AC as a promising waste material for removing heavy metal from wastewater.
Interconnected Stressors and Well-being in Healthcare Professionals
Authors: Lin Liangquan , Zhang Xinqing , Wang Peng 
Published: January 2025

AbstractHealthcare professionals play a crucial role in healthcare systems, but their demanding work significantly impacts their mental and physical health, affecting patient care. This study investigates the interplay of work environment, doctor-patient relationships, media influence, and self-reported health among healthcare professionals. This study employed a stratified sampling approach to survey 8386 healthcare professionals from 40 hospitals across 8 provinces in China. Gaussian Graphical Modeling was used to analyze factors impacting well-being, including physical and mental health, work environment, doctor-patient relationship, and media influence. Network visualization identified key nodes, and the accuracy and stability of the network were assessed. The work environment emerged as a critical bridging factor in the interconnected network. Strong correlations were observed within the work environment cluster, covering aspects related to career, financial, and working conditions. Mental health issues like anxiety and depression also demonstrated moderate co-occurrence. Centrality analysis further identified key nodes associated with job satisfaction, physical fatigue, and mental health symptoms. Work environment plays a central factor interconnecting healthcare professionals' mental health, physical health, doctor-patient relationships, and media influence. Key insights include strong correlations within the work environment cluster, co-occurrence of mental health issues, and the close relationship between physical and psychological well-being. Addressing workplace stressors, fostering positive doctor-patient relationships, and mitigating negative media portrayals can contribute to a healthier environment for healthcare professionals. Comprehensive programs addressing both mental and physical health needs, including mental health screenings, stress management techniques, and promoting physical activity, are crucial.
The Role of Cultural Intelligence and Emotional Intelligence in the Internationalization of SMEs: Does Global Mindset Matter?
Authors: Mammadov Avaz , Wald Andreas 
Published: January 2025

Abstract
Small and medium-sized enterprises (SMEs) increasingly face the imperative of internationalization to remain competitive. Owner-managers of SMEs, who predominantly act as decision-makers, encounter multifaceted challenges in navigating cross-cultural complexities. These challenges can pose significant obstacles to successful expansion into international markets, and prior research has often overlooked the role of owner-managers in SME internationalization models. This study investigates how specific managerial competencies, namely cultural intelligence (CQ) and emotional intelligence (EQ), influence the degree of internationalization (DOI) of SMEs. Additionally, it examines the mediating role of owner-managers’ global mindset (GM) in this relationship. Based on upper echelons theory, which posits that top managers’ characteristics shape organizational outcomes, the study reveals how these individual-level competencies impact SME internationalization efforts. Data were collected from 399 SME owner-managers in Norway and Azerbaijan, utilizing structural equation modeling to test the hypothesized relationships. Results indicate that higher levels of CQ and EQ among owner-managers positively influence the DOI of SMEs, with GM partially mediating these relationships. This study enhances the body of knowledge on CQ, EQ, and SME internationalization by introducing a comprehensive DOI measurement approach that considers both the proportion and geographic dispersion of foreign sales. Furthermore, this research addresses a significant gap by incorporating GM into the explanation of the SME internationalization process. Finally, it extends theoretical understanding by exploring the often-overlooked application of upper echelons theory to the context of SME internationalization, highlighting the crucial role of specific managerial competencies as drivers of internationalization.
Inflammatory Heart Disease in Multisystem Inflammatory Syndrome
Authors: La Vecchia Giulia , Del Buono Marco Giuseppe , Bonaventura Aldo , Vecchiè Alessandra , Moroni Francesco , Sanna Tommaso , Abbate Antonio 
Published: January 2025

Abstract
Purposeof the Review
In this review article, we aim to provide an overview of the pathophysiology, the clinical features, the therapeutic management and prognosis of patients affected by Multisystemic inflammatory syndrome (MIS) with cardiac involvement, focusing on myocarditis and pericarditis.

Recent Findings
MIS is a multiorgan hyperinflammatory condition due to a cytokine storm following (within 4–12 weeks) SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection. First described in children, it also affects young adults without comorbidities, predominantly males with highly heterogeneous clinical manifestations, including cardiac involvement.

Summary
Pericardial and myocardial involvement are prevalent among patients affected by MIS leading to different clinical manifestations including myocarditis with arrhythmias, acute heart failure and cardiogenic shock that significantly affect the patient's prognosis. The heterogeneity of its clinical features and the significant overlap with other hyperinflammatory diseases make the diagnosis particularly challenging. Moreover, the evidence on the efficacy of pharmacological treatments targeting the hyperinflammatory response is scarce, as well as data on long-term prognosis.
Sexuelle Gewalt in der Hochschullehre
Authors: Wittfeld Meike 
Published: January 2025

Zusammenfassung
Sexuelle Gewalt ist für die Hochschullehre ein herausforderndes Thema, weil es in mehrerlei Hinsicht emotional belastend ist. Gerade in Seminaren sind die Erfahrungen der Studierenden sehr heterogen. Aufgabe von Dozierenden ist es, einen sicheren Raum zu schaffen, in dem Wissen über das Thema vermittelt werden kann, ohne besonders vulnerable Personen zu beschädigen.
A microcontextual investigation of Later Stone Age ash deposits and associated interment of human remains at Faraoskop Rock Shelter, South Africa
Authors: Stahlschmidt Mareike C , Power Robert C , Heinrich Susann , Poggenpoel Cedric , Parkington John 
Published: January 2025

Abstract
The Later Stone Age site Faraoskop Rock Shelter yielded the human remains of twelve individuals in an ash-rich sedimentary sequence that also preserved anthropogenic bedding features. This geoarchaeological study is concerned with the sedimentary context of the human remains, the reconstruction of the human activities that formed the ash deposits as well as the bedding features and the paleoenvironmental conditions during site occupation. To investigate these topics, we employed micromorphological analyses on the deposits coupled with micro-Fourier-Transform-Infrared spectroscopy and phytolith analysis. This approach enabled us to reconstruct site use patterns as well as paleoenvironmental conditions. Our analysis shows a break in site occupation between the Pleistocene and Holocene deposits at the site and before and after the interment of the 12 individuals. The Holocene ash deposits pre-dating the interments result from continuous use of hearths at a central location of the shelter with an increase in fire intensity over time. Site occupants also repeatedly used plant bedding features as living surfaces around the fires and phytolith analysis revealed the particular use of eudicots for some of these bedding features. The occupation of the site took place during grassland regimes with a shift to a shrubbier environmental context during the Holocene. Unfortunately, the direct interment context of the human remains was not available for this study and it remains open what cultural practises may have been preserved in the burial sediments.
Eurasian Beaver (Castor Fiber) Reintroduction: A Nutrient Mitigation Solution for Lowland Chalk Streams?
Authors: Cooper Richard James , Cabrales Samuel , Freeman Eleanor , Holroyd Erin , Wyatt Joe , Tosney Jonah 
Published: January 2025

Abstract
Globally scarce and ecologically valuable, the lowland chalk streams of southern and eastern England experience extensive eutrophication pressures arising from intensive agriculture. Mitigation measures are required to restore natural chalk stream functioning and the reintroduction of the Eurasian beaver (Castor fiber) could provide a solution. Here, we investigated the impact upon chalk stream hydrochemistry of the reintroduction of beavers to a 6-ha enclosure on the headwaters of the River Glaven, Norfolk. Over a two-year period (March 2022 – May 2024), 190 river water samples were collected across control and impact sites displaying minor-to-major hydrological disturbance from beaver activity, with samples analysed for nitrate (NO3), phosphate (PO4), and dissolved organic carbon (DOC). Results revealed significant reductions in nutrient concentrations downstream of the beaver enclosure (NO3 = -43%; PO4 = -51%), as well as significantly lower concentrations relative to the agricultural control site (NO3 = -64%; PO4 = -86%). Conversely, DOC concentrations were significantly higher downstream of the enclosure (+ 94%) and compared to the control (+ 272%). Greater reductions in nitrate and phosphate during the summer (NO3 = -47%; PO4 = -61%) compared to winter (NO3 = -37%; PO4 = -38%) indicated biological assimilation within the beaver wetland as a likely causal mechanism, whilst lower dissolved oxygen concentrations within the beaver ponds indicated a role for denitrification in nitrate removal. Overall, these results demonstrate that beaver wetlands can significantly mitigate eutrophication risk in agriculturally impacted chalk streams and provides further evidence in support of their wider reintroduction to English catchments.
Quantitative failure analysis for IoT systems: an integrated model-based framework
Authors: Abdulhamid Alhassan , Kabir Sohag , Ghafir Ibrahim , Lei Ci 
Published: January 2025

Abstract
The widespread adoption of Internet of Things (IoT) systems emphasises the need for dependable performance. However, challenges emerge due to the inadequacy of informal failure analysis models in evaluating the complex and distributed nature of IoT designs. These challenges can lead to inconsistencies, complicated system modifications, and extended development timelines. This paper presents a Model-Based Systems Engineering (MBSE) approach to create an integrated quantitative analysis framework for assessing the reliability of IoT systems. This approach simplifies the modelling and analysis of failure behaviours in IoT design, linking failure models to system design using standard engineering frameworks. Based on descriptions of IoT systems, the integrated approach establishes a traceability link between the system description and the analysable artefacts generated, such as stochastic Fault Tree Analysis (FTA) and Bayesian network (BN) models, which are essential for effective failure analysis of IoT systems. The approach demonstrates how to quantify system-level failures, identify and prioritise the weakest links in the design, and show how targeted modifications can improve the overall reliability of IoT systems. An illustrative case study on IoT is included to highlight the effectiveness and practical applicability of the proposed framework.
Exploring the protective role of metformin and dehydrozingerone in sodium fluoride-induced neurotoxicity: evidence from prenatal rat models
Authors: Ahuja Tejas , Begum Farmiza , Kumar Gautam , Shenoy Smita , Kumar Nitesh , Shenoy Rekha R. 
Published: January 2025

Abstract
This study is aimed at evaluating the neurotoxic effects of chronic exposure of sodium fluoride (NaF) in developmental stages in rat using prenatal models. NaF (100 ppm, orally) dosing via drinking water was given to pregnant rats in disease group. In the treatment groups, Metformin & Dehydrozingerone (DHZ) (200 mg/kg) were administered orally along with NaF, and the dosing was continued throughout the gestation and lactation periods to the pups until the end of experiment. Behavioural studies like Novel Object Recognition Test (NORT), Open Field & Actophotometer test and biochemical estimations like Acetylcholinesterase (AchE), Glutathione (GSH), Malondialdehyde (MDA) were conducted on animals followed by histopathological image analysis. It was observed that NaF exposure significantly decreased learning, memory and locomotor ability (at p < 0.05, p ≤ 0.01) in rat pups and was also able to induce anxiety like behavior. Levels of AchE (p ≤ 0.001) and MDA (p ≤ 0.01, p ≤ 0.001) was found to be significantly elevated and GSH levels were significantly decreased (p ≤ 0.01, p ≤ 0.001) in hippocampus and frontal cortex in the disease group. Histopathological image analysis showed presence of degenerated neurons in hippocampus of disease group. From this study, it was observed that treatment with Metformin and DHZ, was able to significantly ameliorate the cognitive impairments, improve the condition of oxidative stress and decrease neuronal degeneration in NaF fed rat pups. These results established the protective role of Metformin and DHZ in NaF induced neurodevelopmental toxicity with particular emphasis on their antioxidant properties.
Identification of novel CDH23 heterozygous variants causing autosomal recessive nonsyndromic hearing loss
Authors: Liao Baoqiong , Xie Wuming , Liu Rutian , Zhang Qi , Xie Ting , Jia Dan , He Shuwen , Huang Hailong 
Published: January 2025

Abstract

Background
Hearing loss adversely impacts language development, acquisition, and the social and cognitive maturation of affected children. The hearing loss etiology mainly includes genetic factors and environmental factors, of which the former account for about 50–60%.

Objective
This study aimed to investigate the genetic basis of autosomal recessive non-syndromic hearing loss (NSHL) by identifying and characterizing novel variants in the CDH23 gene. Furthermore, it seeks to determine the pathogenic potential of the noncanonical splice site variant c.2398-6G > A.

Methods
Comprehensive clinical evaluation and whole-exome sequencing (WES) were performed on the girl. The WES analysis revealed two novel variants in the CDH23 gene, associated with nonsyndromic deafness 12 (DFNB12). To further explore the pathogenicity of these variants, functional studies involving in vivo splicing analysis were performed on the novel noncanonical splice site variant, c.2398-6G > A, which was initially classified as a variant of uncertain significance (VUS).

Results
Whole-exome sequencing of the patient identified two compound heterozygous variants in CDH23: c.2398-6G > A, a noncanonical splice site variant, and c.6068C > A (p. Ser2023Ter), a nonsense mutation. In vitro splicing assays demonstrated that c.2398-6G > A caused aberrant splicing, leading to a frameshift (p. Val800Alafs*6) and the production of a truncated protein, as confirmed by structural protein analysis. The study revealed novel mutations as likely pathogenic, linking both variants to autosomal recessive NSHL.

Conclusions
Our analyses revealed novel compound heterozygous mutations in CDH23 associated with autosomal recessive NSHL, thereby expanding the mutational landscape of CDH23-related hearing loss and increasing knowledge about the CDH23 splice site variants.
Trust, Explainability and AI
Authors: Baron Sam 
Published: January 2025

Abstract
There has been a surge of interest in explainable artificial intelligence (XAI). It is commonly claimed that explainability is necessary for trust in AI, and that this is why we need it. In this paper, I argue that for some notions of trust it is plausible that explainability is indeed a necessary condition. But that these kinds of trust are not appropriate for AI. For notions of trust that are appropriate for AI, explainability is not a necessary condition. I thus conclude that explainability is not necessary for trust in AI that matters.
Anthropometric Measurements and Laboratory Methods for Pregnancy: An Update Review to Evaluation of Body Composition
Authors: Açar Yasemin , Köksal Eda 
Published: January 2025

Abstract
Purpose of Review
The aim of this review is to summarize and put into context the current evidence on anthropometric measurements and laboratory methods used in the evaluation of body composition in pregnancy, in the light of current studies.

Recent Findings
Protecting women's health during pregnancy, childbirth and the postnatal period is important for maternal health. Pregnancy is a critical period during which the female body undergoes significant changes to support fetal growth and development. Maternal changes in body composition are associated with fatal development and maternal health during pregnancy. Anthropometry is a simple, reliable, and low-cost method that can be applied globally in primary care for evaluating maternal nutritional status. Maternal anthropometry is important in predicting various complications that may occur during pregnancy, such as intrauterine growth retardation and the risk of low birth weight. In this context, anthropometric measurements such as body weight, skinfold thickness, and middle upper arm circumference, and laboratory methods such as body water, body density, bioelectrical impedance analysis, ultrasound, dual-energy X-ray absorptiometry, and magnetic resonance imaging are frequently used in estimating the body composition of pregnant women. In addition to body weight gain monitoring, it is possible to determine the body composition of a pregnant woman by using different anthropometric measurements and the proposed equations.

Summary
Accurate evaluation of anthropometric measurements and body composition in pregnant women is important in protecting the health of the mother and baby and in the early diagnosis of complications that may occur during pregnancy.
Adaptive Gaussian Mixture Filtering for Multi-sensor Maneuvering Cislunar Space Object Tracking
Authors: Iannamorelli John L. , LeGrand Keith A. 
Published: January 2025

AbstractSuccessful space domain awareness (SDA) requires maintaining track custody of cooperative and noncooperative cislunar space objects (CSOs) through both ballistic and maneuvering trajectories. The surveillance of CSOs is particularly challenging due to the underlying chaotic multi-body dynamics, which makes uncertainty propagation more difficult when compared to Keplerian orbits. While methods exist for tracking cooperative spacecraft using high accuracy range measurements, the problem of passive noncooperative maneuvering CSO tracking has received considerably less attention. In this paper, CSO motion is modeled as a jump Markov system (JMS), where the CSO modality is unknown and subject to random switching. A novel adaptive Bayesian filter is proposed and shown to successfully maintain CSO track custody through both ballistic and maneuvering phases of an Artemis I-like trajectory.