bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemanfaatan Lagu untuk Meningkatkan Perbendaharaan Kata Bahasa Inggris
Authors: Nurdin Nurdin , Yunansyahtika Ragil , Devi Maria Imaculata Zetta 
Published: August 2023

Perbendaharaan kata bahasa Inggris adalah aspek penting untuk menunjang pemahaman bahasa Inggris para peserta didik. Kegiatan pengabdian mahasiswa kepada masyarakat yang diselenggarakan bertujuan untuk meningkatkan perbendaharaan kata bahasa Inggris di SD N 1 Daru, Tangerang. Kegiatan PMkM menggunakan metode pembelajaran fun-learning yaitu memberikan kosakata melalui lagu yang relevan dengan kehidupan sehari-hari. Lagu yang digunakan adalah twinkle-twinkle little star, Old MacDonald Had Farm, dan Fruit Song. Tidak hanya berpatokan pada lirik lagu yang disediakan melainkan juga mengembangkan tema masing-masing lagu untuk lebih memperkaya perbendaharaan kata. Proses evaluasi yang dilakukan guna mengetahui hasil pemahaman para siswa dengan melakukan pengamatan pada respons siswa dan latihan menuliskan kosakata terkait materi yang telah diberikan. Setelah pengamatan respons siswa, hasil pekerjaan di koreksi dan dilakukan pengumpulan data, ditemukan bahwa mayoritas siswa telah berhasil mencapai keberhasilan tolok ukur kegiatan pengabdian. Kegiatan PMkM ini diharapkan dijadikan acuan oleh pihak mitra untuk berinovasi mengembangkan metode pembelajaran sesuai kebutuhan zaman.
`Workshop Penulisan Karya Tulis Ilmiah untuk Pemuda Karang Taruna BPI V Tangerang Selatan
Authors: Abdullah Varatisha Anjani 
Published: August 2023

Karya Tulis Ilmiah (KTI) merupakan tulisan yang menjelaskan sebuah fenomena berdasarkan fakta, berlandaskan teori dalam memecahkan persolan yang diangkat. Kegiatan pelatihan KTI dapat meningkatkan kompetensi penulisan. Kegiatan Pengabdian Kepada Masyarakat ini dilakukan sebagai upaya meningkatkan kompetensi menulis KTI Pemuda Karang Taruna RW 10 Bukit Pamulang Indah V Tangerang Selatan Banten. Kegiatan ini dilakuan secara virtual dengan mengundang anak muda di sekitar wilayah Bukit Pamulang Indah . Peserta secara aktif mengikuti pelatihan yang diselenggrakan oleh civitas akademika Institut Seni Indonesia Surakarta pada 17 Maret, 31 Maret dan 14 April 2023. Hasil dari kegiatan PkM ini memberikan simpulan bahwa pada dasranya memiliki kompetensi menulis yang baik. Hal ini terbukti dari proses diskusi dua arah yang aktif serta penyelesaian tugas yang diberikan. Harapan dari kegiatan PkM ini menigkatnya kompetensi penulisan KTI pada anak muda khususnya para peserta kegiatan PKM sehingga KTI yang mereka buat dapat bermanfaat untuk perkembangan ilmu pengetahuan.
The remote diet intervention to reduce Long COVID symptoms trial (ReDIRECT): protocol for a randomised controlled trial to determine the effectiveness and cost-effectiveness of a remotely delivered supported weight management programme for people with Long COVID and excess weight, with personalised improvement goals
Authors: Haag Laura , Richardson Janice , Cunningham Yvonne , Fraser Heather , Brosnahan Naomi , Ibbotson Tracy , Ormerod Jane , White Chris , McIntosh Emma , O'Donnell Kate , Sattar Naveed , McConnachie Alex , Lean Michael E. J. , Blane David N. , Combet Emilie 
Published: August 2023

Objectives: The Remote Diet Intervention to Reduce Long COVID Symptoms Trial (ReDIRECT) evaluates whether the digitally delivered, evidence-based, cost-effective Counterweight-Plus weight management programme improves symptoms of Long COVID in people with overweight/obesity. Methods: Baseline randomised, non-blinded design with 240 participants allocated in a 1:1 ratio either to continue usual care or to add the remotely delivered Counterweight-Plus weight management programme, which includes a Counterweight dietitian supported delivery of 12 weeks total diet replacement, food reintroduction, and long-term weight loss maintenance. Randomisation is achieved by accessing a web-based randomisation system incorporated into the study web portal developed by a registered Clinical Trials Unit. We are using an innovative approach to outcome personalisation, with each participant selecting their most dominant Long COVID symptom as their primary outcome assessed at six months. Participants in the control arm enter the weight management programme after six months. We are recruiting participants from social media and existing networks (e.g., Long COVID Scotland groups), through newspaper advertisements and from primary care. Main inclusion criteria: people with Long COVID symptoms persisting > three months, aged 18 years or above, body mass index (BMI) above 27kg/m2 (>25kg/m2 for South Asians). The trial includes a process evaluation (involving qualitative interviews with participants and analysis of data on dose, fidelity and reach of the intervention) and economic evaluation (within-trial and long-term cost-utility analyses). Anticipated results: The recruitment for this study started in December 2021 and ended in July 2022. Project results are not yet available and will be shared via peer-reviewed publication once the six-months outcomes have been analysed. Trial registration: Current Controlled Trials ISRCTN12595520
Association among Timing of First Visit, Antenatal Care Frequency, and Anaemia Gravidarum during the Peak Period of the COVID-19 Pandemic
Authors: Hani Salsabilla Permata , Kuntari Titik 
Published: August 2023

Anaemia gravidarum is a health problem that affects pregnancy outcomes. Antenatal care is an effort to screen high-risk pregnancies to provide earlier appropriate management. In 2021, the pandemic forced people to limit their activities, including antenatal care (ANC) visits. The study aimed to explain the association among the timing of the first visit, ANC frequency, and incidence of anaemia gravidarum. The case-control study used the medical record data from Puskesmas Godean 2. The subjects were 30 pregnant women with anaemia in the case group and 30 non-anaemic pregnant women in the control group. The dependent variable was the incidence of anaemia gravidarum. Other variables included age, occupation, and education of the mother, partner’s education, parity status, pregnancy spacing, nutritional status, and history of comorbidities. The chi-square and logistic regression were used to analyse the data. It was found that ANC frequency of less than four times and first visit (K1) after passing the first trimester of gestational age increased the risk of anaemia gravidarum (p-value <0.05). Efforts to increase awareness of the importance of immediate first ANC visit and frequency of ANC visits need to be made to reduce the risk of anaemia gravidarum.
Tuberculosis Related Ischemic Stroke : A Case Report
Authors: Pinzon Rizaldy Taslim , Vidyatama Veren Amoreta 
Published: August 2023

Tuberculosis (TB) is a widespread infectious disease caused by Mycobacterium Tubercle Bacilli. In 15-20 % cases of active pulmonary TB, infection spreads to extrapulmonary foci, including the nervous system complications. Ischemic stroke related tuberculosis without meningitis is rare. We report a 74-year-old female presented with rapid onset confusion, unconsciousness, and left hemiparesis. She had been recently diagnosed with active TB 3 months ago and treated with combination anti tuberculosis regiment. Her recent acute neurological manifestations began within 24 hours prior to admission in the hospital. The brain CT showed middle cerebral artery territory infarction. The risk factors tracing found no significant abnormality. The only abnormal finding was high CRP. This report describes rare case of a patient with active TB and who presented with acute ischemic stroke.
of Ethanol Extract of Cinnamon Bark (Cinnamomum burmanii) on the Lipid Profile and Malondialdehyde of Dyslipidemic Rats
Authors: Dewi Ratih Handayani  , Sari Sylvia Mustika Sari , Darojat Muhammad Danil Hadyan , Permatasari Elok Yana , Djamaludin Maman 
Published: August 2023

Dyslipidemia is a risk factor for atherosclerosis. Dyslipidemia conditions and malondialdehyde (MDAs) increased can cause oxidative stress. Cinnamon contains antioxidant compounds that have a hypolipidemic effect. This study aimed to determine the effect of cinnamon bark ethanol extract on triglycerides, total cholesterol, LDL, HDL, and MDA in dyslipidemic rats. In this study, rats were divided into five groups, a negative control group: which received standard feed, a positive control group: which received a high-fat diet and PTU, the groups that received a high-fat diet, PTU, cinnamon bark ethanol extract (EECB) 125 mg/Kg BW, 250 mg/Kg BW, 500 mg/Kg BW. The results of the analysis showed a decrease in triglyceride levels in all groups given EECB (p <0.05). Total and LDL cholesterol levels decreased in the 125 mg/Kg BW EECB group, and malondialdehyde decreased in the 500 mg/Kg BW EECB group (p <0.05). HDL levels did not increase. The ethanol extract of cinnamon bark was able to improve lipid profiles because it contains cinnamaldehyde and quercetin that can inhibit HMG CoA reductase activity, as well as flavonoids, tannins, and cinnamate which are able to reduce triglyceride and MDA levels.
Keywords: cinnamon, dyslipidemia, malondialdehyde, lipid profile.
Right ventricular global dysfunction score: a new concept of right ventricular function assessment in patients with heart failure with reduced ejection fraction (HFrEF)
Authors: Benes Jan , Kotrc Martin , Wohlfahrt Peter , Kroupova Katerina , Tupy Marek , Kautzner Josef , Melenovsky Vojtech 
Published: August 2023

BackgroundRight ventricular (RV) function is currently being evaluated solely according to the properties of RV myocardium. We have tested a concept that in patients with heart failure with reduced ejection fraction (HFrEF), RV assessment should integrate the information about both RV function as well as size.MethodsA total of 836 stable patients with HFrEF (LVEF 23.6 ± 5.8%, 82.8% males, 68% NYHA III/IV) underwent echocardiographic evaluation and were prospectively followed for a median of 3.07 (IQRs 1.11; 4.89) years for the occurrence of death, urgent heart transplantation or implantation of mechanical circulatory support.ResultsRV size (measured as RV-basal diameter, RVD1) was significantly associated with an adverse outcome independent of RV dysfunction grade (p = 0.0002). The prognostic power of RVD1 was further improved by indexing to body surface area (RVD1i, p &lt; 0.05 compared to non-indexed value). A novel parameter named RV global dysfunction score (RVGDs) was calculated as a product of RVD1i and the degree of RV dysfunction (1–4 for preserved RV function, mild, moderate and severe dysfunction, respectively). RVGDs showed a superior prognostic role compared to RV dysfunction grade alone (ΔAUC &gt;0.03, p &lt; 0.0001). In every subgroup of RVGDs (&lt;20, 20–40, 40–60, &gt;60), patients with milder degree of RV dysfunction but more dilated RV had similar outcome as those with more severe degree of RV dysfunction but smaller RV size (all p &gt; 0.50), independent of tricuspid regurgitation severity and degree of pulmonary hypertension.ConclusionRV dilatation is a manifestation of RV dysfunction. The evaluation of RV performance should integrate the information about both RV size and function.
Gut microbiome and reproductive endocrine diseases: a Mendelian randomization study
Authors: Liang Ye , Zeng Weihong , Hou Tao , Yang Haikun , Wu Boming , Pan Ru , Huang Lishan 
Published: August 2023

BackgroundObservation studies have confirmed the association between the gut microbiome and reproductive endocrine diseases (REDs), namely, polycystic ovary syndrome (PCOS), endometriosis, and female infertility. However, their association has never been confirmed by a two-sample Mendelian randomization (MR) analysis.MethodsWe conducted a two-sample MR analysis to evaluate the relationship between the gut microbiome and the three aforementioned REDs. In order to get more comprehensive results, two different thresholds were adopted to select instrumental variables (IVs): one was a locus-wide significance threshold (P &lt;1.0×10–5) and the other was a genome-wide significance level (P&lt; 5×10-8). Summary-level statistics for the gut microbiome and REDs were collected from public databases. Inverse-variance weighted (IVW) was the main method used to estimate causality, and sensitivity analyses were conducted to validate the MR results.ResultsAt the locus-wide significance level, we identified that the genera Streptococcus (OR=1.52, 95%CI: 1.13-2.06, P=0.006) and RuminococcaceaeUCG005 (OR=1.39, 95%CI: 1.04-1.86, P=0.028) were associated with a high risk of PCOS, while Sellimonas (OR= 0.69, 95%CI: 0.58-0.83, P=0.0001) and RuminococcaceaeUCG011(OR=0.76, 95%CI: 0.60-0.95, P=0.017) were linked to a low PCOS risk. The genus Coprococcus2 (OR=1.20, 95%CI: 1.01-1.43, P=0.039) was correlated with an increased risk of female infertility, while Ruminococcus torques (OR=0.69, 95%CI: 0.54-0.88, P=0.002) were negatively associated with the risk of female infertility. The genera Olsenella (OR= 1.11, 95%CI: 1.01-1.22, P=0.036), Anaerotruncus (OR= 1.25, 95%CI: 1.03-1.53, P=0.025), and Oscillospira (OR= 1.21, 95%CI: 1.01-1.46, P=0.035) were linked to a high risk of endometriosis. However, the results showed that the gut microbiome did not possess a causal link with REDs risk based on the genome-wide significance level. Sensitivity analyses further confirmed the robustness of the MR results.ConclusionOur study provides evidence that gut microbiome is closely related with REDs. Subsequent studies should be conducted to promote microbiome-orientated therapeutic strategies for managing REDs.
Characteristics of agricultural phosphorus migration in different soil layers on purple soil sloping cropland under natural rainfall conditions
Authors: Wang Yi , Chen Fangxin , Zhao Huan , Xie Deti , Ni Jiupai , Liao Dunxiu 
Published: August 2023

Limited by the current monitoring and collection methods of subsurface flow data, the characteristics of phosphorus (P) migration loss in different soil layers on sloping cropland under natural rainfall conditions need to be clarified. In this study, a reliable U-trough collection method was used to explore P migration losses in different purple soil layers (L0: surface, L1: 0–20 cm, L2: 20–40 cm, and L3: 40–60 cm) for purple soil sloping cropland during a field monitoring campaign spanning two calendar years under natural rainfall conditions. The results suggested that the annual surface P loss load was 1.08 kg*ha−1*yr−1, where 92.1% was particulate P. The annual leaching loss load of total P from the L1 layer was 3.55 kg*ha−1*yr−1, where 74.2% and 10.5% were intercepted by the L2 and L3 layers, respectively, to increase the in situ soil P stocks. Only 15.3% of L1’s annually leached P, and only half the surface P loss load (L0), was lost to underground water. Heavy-rain events on the purple soils in the studied sloping cropland induced 43.9% of the annual surface P loss load. In contrast, 36.1%, 30.5%, and 30.3% of P’s eventual annual leached loss loads resulted from heavy, moderate, and torrential rain events, respectively. The maize season was the main period of surface and subsurface P migration loss. Due to the limitation of experimental conditions, the results of this experiment could not represent the soil phosphorus migration process in the natural purple slope farmland in nature, but it could partially represent the soil phosphorus migration in the newly cultivated purple sloping cropland in Chongqing.
Increased liver stiffness promotes hepatitis B progression by impairing innate immunity in CCl4-induced fibrotic HBV+ transgenic mice
Authors: Bybee Grace , Moeun Youra , Wang Weimin , Kharbanda Kusum K. , Poluektova Larisa Y. , Kidambi Srivatsan , Osna Natalia A. , Ganesan Murali 
Published: August 2023

BackgroundHepatitis B virus (HBV) infection develops as an acute or chronic liver disease, which progresses from steatosis, hepatitis, and fibrosis to end-stage liver diseases such as cirrhosis and hepatocellular carcinoma (HCC). An increased stromal stiffness accompanies fibrosis in chronic liver diseases and is considered a strong predictor for disease progression. The goal of this study was to establish the mechanisms by which enhanced liver stiffness regulates HBV infectivity in the fibrotic liver tissue.MethodsFor in vitro studies, HBV-transfected HepG2.2.15 cells were cultured on polydimethylsiloxane gels coated by polyelectrolyte multilayer films of 2 kPa (soft) or 24 kPa (stiff) rigidity mimicking the stiffness of the healthy or fibrotic liver. For in vivo studies, hepatic fibrosis was induced in C57Bl/6 parental and HBV+ transgenic (HBVTg) mice by injecting CCl4 twice a week for 6 weeks.ResultsWe found higher levels of HBV markers in stiff gel-attached hepatocytes accompanied by up-regulated OPN content in cell supernatants as well as suppression of anti-viral interferon-stimulated genes (ISGs). This indicates that pre-requisite “fibrotic” stiffness increases osteopontin (OPN) content and releases and suppresses anti-viral innate immunity, causing a subsequent rise in HBV markers expression in hepatocytes. In vitro results were corroborated by data from HBVTg mice administered CCl4 (HBVTg CCl4). These mice showed higher HBV RNA, DNA, HBV core antigen (HBcAg), and HBV surface antigen (HBsAg) levels after liver fibrosis induction as judged by a rise in Col1a1, SMA, MMPs, and TIMPs mRNAs and by increased liver stiffness. Importantly, CCl4-induced the pro-fibrotic activation of liver cells, and liver stiffness was higher in HBVTg mice compared with control mice. Elevation of HBV markers and OPN levels corresponded to decreased ISG activation in HBVTg CCl4 mice vs HBVTg control mice.ConclusionBased on our data, we conclude that liver stiffness enhances OPN levels to limit anti-viral ISG activation in hepatocytes and promote an increase in HBV infectivity, thereby contributing to end-stage liver disease progression.
Impaired thymic iNKT cell differentiation at early precursor stage in murine haploidentical bone marrow transplantation with GvHD
Authors: Zhao Weijia , Wang Yujia , Zhang Xinwei , Hao Jie , Zhang Kunshan , Huang Xiaojun , Chang Yingjun , Wu Hounan , Jin Rong , Ge Qing 
Published: August 2023

IntroductionEarly recovery of donor-derived invariant natural killer T (iNKT) cells are associated with reduced risk of graft-versus-host disease (GvHD) and overall survival. Patients with severe GvHD, however, had much slower iNKT cell reconstitution relative to conventional T cells.MethodsTo characterize the delay of iNKT cell reconstitution and explore its possible causes, we used a haploidentical bone marrow transplantation (haplo-BMT) mouse model with GvHD. We found the delayed recovery of thymic and peripheral iNKT cell numbers with markedly decreased thymic NKT1 subset in GvHD mice. The defective generation of thymic iNKT precursors with egress capability contributed to the reduced peripheral iNKT cells in GvHD mice. We further identified intermediate NK1.1- NKT1 precursor subpopulations under steady-state conditions and found that the differentiation of these subpopulations was impaired in the thymi of GvHD mice. Detailed characterization of iNKT precursors and thymic microenvironment showed a close association of elevated TCR/co-stimulatory signaling provided by double positive thymocytes and macrophages with defective down-regulation of proliferation, metabolism, and NKT2 signature in iNKT precursor cells. Correspondingly, NKT2 but not NKT1 differentiation was favored in GvHD mice.DiscussionThese data underline the important roles of TCR and co-stimulatory signaling in the differentiation of thymic iNKT subsets under transplantation conditions.
Proinflammatory role of monocytes in SARS-CoV-2 infection in chronic hemodialysis patients
Authors: Bumbea Viorica , Ardelean Luminita , Radulescu Luminita , Damian Luminita , Bumbea Horia , Dumitru Ion , Lambert Claude , Vladareanu Ana-Maria 
Published: August 2023

BackgroundFully mature monocytes that express CD14, but not CD16, undergo phagocytosis within tissues, whereas non-classical monocytes, CD14-low CD16+, represent &lt;11% of peripheral monocytes and have primary pro-inflammatory functions. Inflammation plays a major role in Covid-19 disease and adds to the inflammation caused by chronic hemodialysis. The aim of our study was to monitor monocyte subsets in five patients with end-stage kidney disease (ESKD) over a 1-year period after a mild Covid-19 infection. Five ESKD patients with a mild Covid-19 infection were monitored using CD14, CD16, CD300e, HLA-DR, CD64, and CD45 panels using a BD FACS Canto flow cytometer.ResultsCD14-low CD16+ was dramatically (p=0,001) decreased in patients during Covid-19 infection, as previously described for patients without chronic renal failure. In addition, CD14-low CD16+ monocytes remained decreased for 10 months after recovery from Covid. Intermediate monocytes increased during Covid-19 infection and decreased 10 months after infection but this subtype of monocytes retained their inflammatory activity with a significant increase in HLA-DR expression after recovery from Covid infection.ConclusionOur study shows that ESKD patients had a pro-inflammatory profile induced by Covid 19, but this status was prolonged significantly over a 10-month period. Thus, advanced renal failure treated by hemodialysis did not dramatically change the inflammatory response against to SARS Covid 2. It seems that monocytes retain their inflammatory status for many months in ESKD patients after a Covid-19 infection.
Adsorption of toxic dye using red seaweeds from synthetic aqueous solution and its application to industrial wastewater effluents
Authors: Al-Saeedi Sameerah I. , Ashour Mohamed , Alprol Ahmed E. 
Published: August 2023

This study investigated the potential application of dried powder from red seaweedPterocladia capillaceaas an eco-friendly adsorbent for removing Crystal Violet Dye (CV dye) from a synthetic solution. The adsorption conditions for the adsorbent were determined, in batch conditions, by changing different experimental parameters such as initial CV dye concentrations (5, 10, 20, 30, and 40 mg L–1), contact time (15, 30, 60, 120, and 180 min.), adsorbent doses (0.025, 0.05, 0.1, 0.2, and 0.3 g), temperature (25, 35, 45, and 55°C), and pH (3, 5, 7, 9, and 11). The adsorption mechanisms of CV dye onto theP. capillaceabiomass were examined using various analytical techniques such as FTIR, BET, UV–Visible, and SEM. These characterizations suggest the average BET surface area ofP. capillaceawas 87.17 m2g–1and a pore volume of 0.10368 cc g−1. Moreover, according to the FTIR study, the dye has been deposited inside the adsorbent’s pores after adsorption. The adsorption behavior of the adsorbent was investigated by performing both kinetic and equilibrium isothermal studies in batch conditions at 25°C. Also, the thermodynamic factors showed the exothermic nature and physisorption of the adsorption process, which tends to be spontaneous at lower temperatures. In addition, Langmuir, Dubinin-Radushkevich, Freundlich, and Tempkin isotherm models were selected to evaluate the adsorption of CV dye onP. capillacea. The equilibrium adsorption data were best represented by the Freundlich, indicating multilayer adsorption on the heterogeneous surface. The qeexperiment and calculation values for the Pseudo-Second-Order and interparticle diffusion kinetic models were determined. The results showed that, under optimum conditionsP. capillaceaexhibited 98% removal of CV dye from synthetic wastewater. Moreover, it will help to regenerate the adsorbents that can be reused to adsorb CV dye ions and develop a successful adsorption process. Finally, this study concluded that the dried powdered form ofP. capillaceais an attractive source for adsorbing CV dye from aqueous solution.