bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of reward and location on dogs’ behaviour toward an interactive artificial agent
Authors: Capitain Svenja , Miklósi Ádám , Abdai Judit 
Published: January 2023

AbstractAnimal–robot interaction studies provide outstanding opportunities to understand the principles of social interactions. Here we investigated whether dogs’ behaviour toward a cooperative artificial agent (Unidentified Moving Object (UMO)) is influenced by receiving a reward directly from the agent, and by variability in the UMO’s location. In a problem-solving task, the UMO either helped dogs to obtain food (Direct Reward Group, DRG) or to fetch an object followed by an indirect reward from the owner/experimenter (Indirect Reward Group, IRG). During the Familiarization, the UMO either started from the same location or changed its starting location in all trials. In the Test phase, dogs faced the same task, but additionally a second, unfamiliar UMO was present. We found that both reward groups gazed at the UMO with decreasing latency during the Familiarization, with the IRG showing more gaze alternations between UMO and hiding location. Dogs showed no preference for either UMO in the Test phase but looked at the familiar UMO sooner if it had changed its location during the Familiarization. Thus, direct reward is not necessary to elicit elements of socially competent behavior in dogs, but variability in its motion may be important to improve the UMO’s animacy and promote flexible learning.
A deep learning model incorporating spatial and temporal information successfully detects visual field worsening using a consensus based approach
Authors: Sabharwal Jasdeep , Hou Kaihua , Herbert Patrick , Bradley Chris , Johnson Chris A. , Wall Michael , Ramulu Pradeep Y. , Unberath Mathias , Yohannan Jithin 
Published: January 2023

AbstractGlaucoma is a leading cause of irreversible blindness, and its worsening is most often monitored with visual field (VF) testing. Deep learning models (DLM) may help identify VF worsening consistently and reproducibly. In this study, we developed and investigated the performance of a DLM on a large population of glaucoma patients. We included 5099 patients (8705 eyes) seen at one institute from June 1990 to June 2020 that had VF testing as well as clinician assessment of VF worsening. Since there is no gold standard to identify VF worsening, we used a consensus of six commonly used algorithmic methods which include global regressions as well as point-wise change in the VFs. We used the consensus decision as a reference standard to train/test the DLM and evaluate clinician performance. 80%, 10%, and 10% of patients were included in training, validation, and test sets, respectively. Of the 873 eyes in the test set, 309 [60.6%] were from females and the median age was 62.4; (IQR 54.8–68.9). The DLM achieved an AUC of 0.94 (95% CI 0.93–0.99). Even after removing the 6 most recent VFs, providing fewer data points to the model, the DLM successfully identified worsening with an AUC of 0.78 (95% CI 0.72–0.84). Clinician assessment of worsening (based on documentation from the health record at the time of the final VF in each eye) had an AUC of 0.64 (95% CI 0.63–0.66). Both the DLM and clinician performed worse when the initial disease was more severe. This data shows that a DLM trained on a consensus of methods to define worsening successfully identified VF worsening and could help guide clinicians during routine clinical care.
Appetite loss and associated factors at 1 year after intensive care unit elder survivors in a secondary analysis of the SMAP-HoPe study
Authors: Kitayama Mio , Unoki Takeshi , Sasaki Aki , Sakuramoto Hideaki , Uemura Sakura , Tsujimoto Takahiro , Yamaguchi Takako , Shiba Yuko , Hino Mayumi , Kuribara Tomoki , Fukuda Yuko , Nagao Takumi , Shirasaka Masako , Haruna Junpei , Satoi Yosuke , Masuda Yoshiki 
Published: January 2023

AbstractAppetite loss, a common but serious issue in older patients, is an independent risk factor for sarcopenia, which is associated with high mortality. However, few studies have explored the phenomenon of appetite loss after discharge from the intensive care unit (ICU). Therefore, we aimed to describe the prevalence of appetite loss and relationship between appetite loss and depression in patients living at home 12 months after intensive care. This study involved secondary analysis of data obtained from a published ambidirectional study examining post-intensive care syndrome 12 months after discharge (SMAP-HoPe study) conducted in 12 ICUs in Japan. We included patients aged > 65 years. The Short Nutritional Assessment Questionnaire and Hospital Anxiety Depression Scale were used for the analysis. Descriptive statistics and a multilevel generalized linear model were used to clarify the relationship between appetite loss and depression. Data from 468 patients were analyzed. The prevalence of appetite loss was 25.4% (95% confidence interval [CI], 21.5–29.4). High severity of depression was associated with a high probability of appetite loss (odds ratio, 1.2; 95%CI, 1.14–1.28; p = 0.00). Poor appetite is common 12 months after intensive care and is associated with the severity of depression.
Preservation of dendritic D2 receptor transmission in substantia nigra dopamine neurons with age
Authors: Troyano-Rodriguez Eva , Blankenship Harris E. , Handa Kylie , Branch Sarah Y. , Beckstead Michael J. 
Published: January 2023

AbstractSubstantia nigra pars compacta (SNc) dopamine neurons are required for voluntary movement and reward learning, and advanced age is associated with motor and cognitive decline. In the midbrain, D2-type dopamine receptors located at dendrodendritic synapses between dopamine neurons control cell firing through G protein-activated potassium (GIRK) channels. We previously showed that aging disrupts dopamine neuron pacemaker firing in mice, but only in males. Here we show that the amplitude of D2-receptor inhibitory postsynaptic currents (D2-IPSCs) are moderately reduced in aged male mice. Local application of dopamine revealed a reduction in the amplitude of the D2-receptor currents in old males compared to young, pointing to a postsynaptic mechanism. Further experiments indicated that reduced D2 receptor signaling was not due to a general reduction in GIRK channel currents or degeneration of the dendritic arbor. Kinetic analysis showed no differences in D2-IPSC shape in old versus young mice or between sexes. Potentiation of D2-IPSCs by corticotropin releasing factor (CRF) was also not affected by age, indicating preservation of one mechanism of plasticity. These findings have implications for understanding dopamine transmission in aging, and reduced D2 receptor inhibition could contribute to increased susceptibility of males to SNc dopamine neuron degeneration in Parkinson’s disease.
A new model for the treatment of type 2 diabetes mellitus based on rhythm regulations under the framework of psychosomatic medicine: a real-world study
Authors: Min Wenjiao , Sun Xueli , Tang Nie , Zhang Yaoyin , Luo Fang , Zhu Min , Xia Wei , Zhou Bo 
Published: January 2023

AbstractWe aimed to explore a new treatment model for type 2 diabetes mellitus (DM) based on rhythm regulation under the framework of psychosomatic medicine. Using psychotropics as rhythm regulators, 178 patients with DM were evaluated and divided into three groups: the antidiabetic treatment group (AT group), psychotropic treatment group (PT group), and combined antidiabetic + psychotropic treatment group (combined group), for a course of 16 weeks. The West China Psychiatry Association (WCPA) Somatic Symptom Classification Scale (SSCS) was used to evaluate each patient. The levels of hormones in the hypothalamic–pituitary–adrenal (HPA) and hypothalamic-pituitary-thyroid axes and of blood glucose and glycosylated hemoglobin (HbA1c) were evaluated both before and after treatment. After the treatment, the blood glucose and HbA1c levels in all three groups were lower than those at baseline. Furthermore, the incidence of the abnormal HPA axis in the PT group was significantly decreased (P = 0.003), while the incidence of the abnormal HPA axis in the combined group was 0.0%. The five factor scores of the SSCS in the PT and combined groups after treatment were both significantly low (P < 0.01). Both the incidence of abnormal neuroendocrine axes and SSCS scores in the AT group showed no significant difference before and after treatment. “Blood glucose control + rhythm regulation” should be considered as optimised treatment goals for DM. Moreover, some psychotropics could be used as biorhythm regulators, which have good potential value for clinical application.Clinical trial registration number: ChiCTR1800019064. Name of trial registration: Reinterpretation of mechanism and the optimization of treatment for non-infectious chronic diseases under the “stress-dysrhythmia” theory hypothesis. The full trial protocol can be accessed at the Chinese Clinical Trial Registry (http://www.chictr.org.cn/).
An evaluation of the Index4 tool for chemotherapy toxicity prediction in cancer patients older than 70 years old
Authors: Lewis Alexis , Reed Melissa , Walde Natalie , Voutsadakis Ioannis A. 
Published: January 2023

AbstractChemotherapy, although beneficial for improving outcomes in both localized and metastatic cancers, may be associated with significant adverse effects, especially for patients with decreased functional reserves. Prediction of patients who will not tolerate well chemotherapy treatment may help in modifying treatment plans and in reallocating resources to vulnerable patients. One hundred seventeen consecutive cancer patients over the age of 70 scheduled for chemotherapy treatment in a single cancer center were included in the study. Prediction of adverse chemotherapy outcomes were calculated using a prediction tool proposed and validated from the Cancer and Aging Research Group (CARG) and a prediction tool proposed by us, called Index4. The 2 tools were compared for their ability to predict grade 3 and 4 toxicities, Emergency Department (ED) and hospital admissions and chemotherapy discontinuation. The accuracy of both predictive tools was suboptimal. A high CARG score had a sensitivity of 46.3% and a specificity of 82% and an Index4 of 1 or above had a sensitivity of 53.7% and a specificity of 60% in predicting grade 3–4 adverse effects. The performance of the 2 tools in predicting ED and hospital admissions and chemotherapy discontinuation was comparable. An Index4 score of 0 was superior in predicting absence of grade 3–4 toxicities than a low CARG score (p = 0.002, McNemar’s test). The CARG tool for chemotherapy adverse effect prediction in geriatric cancer patients and the Index4 were able to predict adverse outcomes with moderate accuracy. Given its ease of calculation Index4 may be an alternative to CARG tool, suitable for a busy oncology practice.
Sleep deprivation among adolescents in urban and indigenous-rural Mexican communities
Authors: Silva-Caballero Andrea , Ball Helen L. , Kramer Karen L. , Bentley Gillian R. 
Published: January 2023

AbstractComparing the nature of adolescent sleep across urban and more isolated, rural settings through an ecological, cross-cultural perspective represents one way to inform sleep nuances and broaden our understanding of human development, wellbeing and evolution. Here we tested the Social Jetlag Hypothesis, according to which contemporary, urban lifestyles and technological advances are associated with sleep insufficiency in adolescents. We documented the adolescent sleep duration (11–16 years old; X̅ = 13.7 ± 1.21; n = 145) in two small agricultural, indigenous and one densely urban context in Mexico to investigate whether adolescents in socio-ecologically distinct locations experience sleep deprivation. Sleep data was assembled with actigraphy, sleep diaries and standardized questionnaires. We employed multilevel models to analyze how distinct biological and socio-cultural factors (i.e., pubertal maturation, chronotype, napping, gender, working/schooling, access to screen-based devices, exposure to light, and social sleep practices) shape adolescent sleep duration. Results suggest that the prevalence of adolescent short sleep quotas is similar in rural, more traditional environments compared to highly urbanized societies, and highlight the influence of social activities on the expression of human sleep. This study challenges current assumptions about natural sleep and how adolescents slept before contemporary technological changes occurred.
A blueprint for integrating scientific approaches and international communities to assess basin-wide ocean ecosystem status
Authors: Roberts J. Murray , Devey Colin W. , Biastoch Arne , Carreiro-Silva Marina , Dohna Tina , Dorschel Boris , Gunn Vikki , Huvenne Veerle A. I. , Johnson David , Jollivet Didier , Kenchington Ellen , Larkin Kate , Matabos Marjolaine , Morato Telmo , Naumann Malik S. , Orejas Covadonga , Perez J. Angel A. , Ragnarsson Stefán Á. , Smit Albertus J. , Sweetman Andrew , Unger Sebastian , Boteler Benjamin , Henry Lea-Anne 
Published: January 2023

AbstractOcean ecosystems are at the forefront of the climate and biodiversity crises, yet we lack a unified approach to assess their state and inform sustainable policies. This blueprint is designed around research capabilities and cross-sectoral partnerships. We highlight priorities including integrating basin-scale observation, modelling and genomic approaches to understand Atlantic oceanography and ecosystem connectivity; improving ecosystem mapping; identifying potential tipping points in deep and open ocean ecosystems; understanding compound impacts of multiple stressors including warming, acidification and deoxygenation; enhancing spatial and temporal management and protection. We argue that these goals are best achieved through partnerships with policy-makers and community stakeholders, and promoting research groups from the South Atlantic through investment and engagement. Given the high costs of such research (€800k to €1.7M per expedition and €30–40M for a basin-scale programme), international cooperation and funding are integral to supporting science-led policies to conserve ocean ecosystems that transcend jurisdictional borders.
Conformational, crystalline and rheological properties of poly(octadecyl-co-methyl acrylate) statistically random copolymers
Authors: Pan Xuejun , Wu Weiling , Zhu Mo , Yang Jixian , Yan Zhi-Chao , Li Lianwei 
Published: January 2023

This work reports the conformational, crystalline and rheological properties of poly(octadecyl-stat-methyl acrylate) (P(ODAx-stat-MAy)Nb), where Nb is the degree of polymerization, and x and y are the molar fraction of ODA and MA, respectively.
Acoustic and Kinematic Methods of Indexing Spatiotemporal Stability in Children With Developmental Language Disorder
Authors: Benham Sara , Wisler Alan , Berlin Janna , Wang Jun , Goffman Lisa 
Published: January 2023

Purpose:
The spatiotemporal index (STI) is a standard metric for quantifying the stability and patterning of speech movements. The STI has often been applied to individual speech articulators, but an STI derived from the acoustic signal offers a composite and easily obtained measure that incorporates multiple components of the speech production complex. In this work, we examine the relationship between kinematic and acoustic STIs in children with and without developmental language disorder (DLD), with the aim of determining whether the acoustic and kinematic STIs reflect similar degrees of production variability.

Method:
A total of 85 children with DLD and with typical language development (or typically developing [TD] children), aged 4–8 years, were studied. In this methodological article, two experiments were conducted: one deliberately selected because group differences were observed in the kinematic STI (i.e., sentence production) and one in which there were no group differences in the kinematic STI (i.e., nonword production). These two experiments are representative of speech stability studies. The aim was to determine whether the acoustic STI (i.e., amplitude envelope) results aligned with those obtained via the kinematic STI (i.e., lip motion).

Results:
In sentence production, most group differences aligned across kinematic and acoustic STI measures. The acoustic, but not the kinematic, STI showed higher variability in children with DLD compared with the 6-year-old TD group. In nonword production, neither the kinematic STI nor the acoustic STI differentiated children with DLD from TD children. In each experiment, the kinematic and acoustic STIs showed a moderate-to-strong correlation.

Conclusions:
The kinematic and acoustic STIs assess different components of speech movement patterning. However, the relationship between acoustic and kinematic spatiotemporal stability is strong in two tasks of varying linguistic complexity in children with and without DLD. These findings are promising for future experimental work in this area.
Enhancement synthetic aperture imaging algorithm with azimuth missing data
Authors: Jiang Nan , Xin Qin , Zhu Jiahua , Feng Dong , Wang Jian , Huang Xiaotao 
Published: January 2023

AbstractThis letter proposes an improved synthetic aperture imaging algorithm to enhance the imaging performance in the Azimuth Missing Data (AMD) case. The proposed algorithm designs an effective phase compensation function based on the Range Cell Migration Correction (RCMC) echo and first reconstructs the complete RCMC echo from the AMD echo. The accuracy of echo reconstruction is improved, leading to a better imaging result. Numerical simulations and a real measured experiment verify the effectiveness of the proposed algorithm. Furthermore, since the range positions of targets can be located after RCMC processing, only non‐zero RCMC signals are reconstructed. Thus, the computational complexity superiority of the proposed algorithm is obvious, especially when the targets are sufficiently sparse in the range direction.
Facial expression recognition based on improved residual network
Authors: Zhang Weiguang , Zhang Xuguang , Tang Yinggan 
Published: January 2023

AbstractFacial expressions are an important part of human emotional signals and their recognition has become an important topic of research in the field of pattern recognition. Deep learning based methods have achieved great success in the recognition of facial expressions. However, with the evolution of convolution neural networks and the increased network depth, these methods suffer from problems such as degraded network performance and loss of feature information. To address these problems, a novel facial expression recognition algorithm based on an improved residual neural network is proposed. First, a residual neural network is designed to extract deep features while retaining the shallow ones. This can effectively prevent the degradation of network performance. Moreover, when the gradient of the Rectified Linear Units activation function used in the residual module is 0, it will inactivate the neurons and cause a loss of feature information. To address this, the Mish activation function is used instead. The slight allowance for negative values in Mish improves the gradient flow. Next, an inception module is introduced to obtain richer feature information under the same receptive field. Finally, by conducting verification experiments on the public datasets CK+ and KDEF, the authors manage to solve the problems of degraded network performance and insufficient information from extracted features, achieving recognition accuracy rates of 96.37% and 93.38% on the two datasets, respectively.
Mass outflow from the symbiotic binary RS Oph during its 2021 outburst
Authors: Tomov N. A. , Tomova M. T. , Stoyanov K. A. , Bonev T. R. , Zamanov R. K. , Iliev I. Kh. , Nikolov Ya. M. , Marchev D. , Bisikalo D. V. , Kaygorodov P. V. 
Published: January 2023

Context. RS Oph is a symbiotic recurrent nova containing a massive white dwarf with heavy mass loss during activity. In August 2021, it underwent its seventh optical eruption since the end of the 19th century.
Aims. The goal of this work is to analyse the structure of the outflows from the outbursting object.
Methods. Based on broad-band U, B, V, RC, and IC photometry and high-resolution Hα spectroscopy obtained at days 11–15 of the outburst, we derived some parameters of the system's components and outflows and their changes during our observation.
Results. The effective temperature of a warm shell (pseudophotosphere) produced by the ejected material and occulting the hot component of the system was Teff = 15 000 ± 1000 K and the electron temperature of the nebula was Te = 17 000 ± 3000 K throughout the observations. The effective radius of the pseudophotosphere was Reff = 13.3 ± 2.0 R⊙ and the emission measure of the nebula EM = (9.50 ± 0.59) × 1061 cm−3 for day 11 and Reff = 10.3 ± 1.6 R⊙ and EM = (5.60 ± 0.35) × 1061 cm−3 for day 15. To provide this emission measure, the bolometric luminosity of the outbursting object must exceed its Eddington limit. The mass-loss rate of the outbursting object through its wind is much greater than through its streams. The total rate (from wind + streams) was less than (4–5) × 10–5 (d/1.6 kpc)3/2 M⊙ yr–1. The streams are not highly collimated. Their mean outflowing velocities are υb = −3680 ± 60 km s–1 for the approaching stream and υr = 3520 ± 50 km s–1 for the receding one if the orbit inclination is 50°.
Use of Acellular Biologic Matrix Envelope for Cardiac Implantable Electronic Device Placement to Correct Migration into Submuscular Breast Implant Pocket
Authors: Terry Peyton , Bilchick Kenneth , Campbell Chris A. 
Published: January 2023

AbstractBreast implants whether used for cosmetic or reconstructive purposes can be placed in pockets either above or below the pectoralis major muscle, depending on clinical circumstances such as subcutaneous tissue volume, history of radiation, and patient preference. Likewise, cardiac implantable electronic devices (CIEDs) can be placed above or below the pectoralis major muscle. When a patient has both devices, knowledge of the pocket location is important for procedural planning and for durability of device placement and performance. Here, we report a patient who previously failed subcutaneous CIED placement due to incision manipulation with prior threatened device exposure requiring plane change to subpectoral pocket. Her course was complicated by submuscular migration of the CIED into her breast implant periprosthetic pocket. With subcutaneous plane change being inadvisable due to patient noncompliance, soft tissue support of subpectoral CIED placement with an acellular biologic matrix (ABM) was performed. Similar to soft tissue support used for breast implants, submuscular CIED neo-pocket creation with ABM was performed with durable CIED device positioning confirmed at 9 months postprocedure.