bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Mahatiktakam Ghrita as Avapeedak Snehapan in the management of Rakta Arsha (first-degree bleeding hemorrhoids): A study protocol for a single-arm, open-label clinical trial
Authors: Survase Megha Raosaheb , Parida Deepak Kumar 
Published: January 2025

Abstract

BACKGROUND:

Avapeedak Snehapan, the oral administration of medicated ghee, is used for symptomatic relief in first-degree bleeding hemorrhoids. A single-arm, open-label clinical trial was conducted to assess the safety and therapeutic potential of Mahatiktakam Ghrita for managing this condition.

OBJECTIVE:
This study evaluates the therapeutic effects of Mahatiktakam Ghrita as Avapeedaka Snehapana in managing first-degree bleeding hemorrhoids and reducing associated symptoms.

MATERIALS AND METHODS:
This single-arm, open-label clinical trial will enroll 61 participants, aged 30–50 years diagnosed with first-degree bleeding hemorrhoids, indicated for Snehapana therapy, as per selection criteria from the Outpatient Department of Chattrapati Shahu Maharaj Shikshan Sansthan’s Ayurved Mahavidyalaya, Aurangabad, Maharashtra, India. Participants will undergo a preparatory phase of Deepana–Pachana using Gandharvahastadi Kashaya, administered in a dose of 15 mL mixed with 45 mL of lukewarm water, taken twice daily on an empty stomach until optimal digestive capacity (Agni Deepti) is achieved. Once attained, a trial dose of 30 mL Mahatiktakam Ghrita will be administered in the morning, allowing for assessment of the time required for complete digestion. The optimal dose (Uttama Matra) will be calculated based on this trial dose to determine the amount of ghee digestible within 24 h. Snehapana therapy with Uttama Matra will then be administered on alternate days, ranging from three to seven doses, depending on symptomatic relief. Symptoms such as anal pain, bleeding frequency, appetite, and stool consistency will be monitored. The first follow-up will be performed after the completion of oleation therapy, and a second follow-up will take place after the completion of the dietary regimen (Samsarjana Krama), lasting 12–28 days based on the number of administered doses of Sneha. Primary outcomes include changes in the level of bleeding, pain appetite, stool consistency and secondary outcomes include complete blood count, bleeding time, clotting time, and erythrocyte sedimentation rate assessed at baseline, post-snehapana, and post-Samsarjana karma.

DISCUSSION:
This research explores the effectiveness of Mahatiktakam Ghrita as an accessible Ayurvedic treatment for first-degree bleeding hemorrhoids, assessing symptom relief and safety, and its effect on bleeding, pain, and hematological parameters. Findings may support integrating Ayurvedic therapies into broader hemorrhoid management strategies.
The study is registered with the CTRI (CTRI/2023/07/054623; dated July 3, 2023).
Conservative Ayurvedic management of pediatric hematochezia (Sahaja Arsha): A case report
Authors: Kumar Mahapatra Arun , Shrikrishna Rajagopala , Dileep Aparna , Parameswaran Karthik K. 
Published: January 2025

Abstract
Hematochezia (bleeding per rectum) is a common symptom in children that can indicate an underlying emergency and may warrant surgical management. Ayurveda alludes to the condition, but there are no case reports to date that document its successful treatment. This case reports the conservative, standalone Ayurvedic management of vascular malformations in the anorectum and sigmoid colon in a 28-month-old child. Based on Ayurveda, this case was diagnosed as Sahaja Raktarshas (~congenital bleeding hemorrhoids), and the stage presented was associated with Bhinnavit (loose stools), Ama (indigestion), and Agnimandya (loss of appetite). The medications used were Dadimashtaka Churna, Aravindasava, Sutashekhara Rasa, Dhatryadi Lauha, and Kasisadi Taila during various stages of the treatment. Following 98 days of therapeutic intervention, a notable increase was observed in the hemoglobin level, from 7.5 to 10.2 g/dL. Moreover, daily blood loss per rectum decreased from half a cup to no bleeding, and stool consistency changed from loose to normal, progressing from type 6 to type 3 on the Bristol Stool Scale.
Management of chronic plaque psoriasis with Ayurveda therapeutic regimen: A case report
Authors: Archana Kumari , Singh Krishna Kumar 
Published: January 2025

Abstract

BACKGROUND:
Psoriasis is a chronic inflammatory skin condition with significant comorbidities and a profound psychosocial impact. Modern treatments often fall short, leaving the disease underdiagnosed and undertreated.

CASE PRESENTATION:
A 65-year-old male presented with chronic plaque psoriasis, exhibiting dry erythematous plaques on the anterior shin bone and a positive Auspitz sign. Laboratory investigations revealed normal results, except for mildly elevated liver enzyme levels.

INTERVENTION:
Based on Ayurvedic principles, the treatment focused on balancing the vitiated Doshas and enhancing Agnideepana (digestive fire stimulation), Amapachana (metabolic detoxification), Pitta Shamaka (pacifying excess Pitta), Raktaprasadana (blood purification), and Vatanulomana (normalizing Vata). The intervention also included strict dietary modifications and precautions for 3 months, with dietary restrictions maintained for an additional month.

RESULTS:
The patient’s progress was measured using subjective assessments and the Simplified Psoriasis Area Severity Index (SPASI) score. The treatment resulted in significant improvement, with the patient’s SPASI score reducing from 36 to 2. No relapse was noted during the follow-up period. Liver enzyme levels returned to normal.

CONCLUSION:
This case demonstrates the successful management of plaque psoriasis through an Ayurvedic approach, emphasizing the importance of customized therapeutic interventions. The significant improvement without recurrence in this case highlights the potential of Ayurveda in treating chronic conditions such as psoriasis.
Clinico-hematological and Cytogenetic Study of Myeloid Neoplasms: A cross-sectional Study from South India
Authors: Nair Nidhi , Chikkannaiah Panduranga , Venkataramanappa Srinivasamurthy 
Published: January 2025

ABSTRACT

Background:
Myeloid neoplasms are clonal diseases arising in hematopoietic stem or progenitor cells consisting of myeloproliferative neoplasm (MPN), myelodysplastic syndrome (MDS), and acute myeloid leukemia (AML).

Aim:
To re-classify the myeloid neoplasm as per the World Health Organization (WHO)-5 classification and to study the frequency of occurrence and clinical, hematological, and cytogenetic profile of myeloid neoplasms.

Settings and Design:
A cross-sectional study was conducted for a period of 1 and a 1/2 years from January 2019 to June 2020.

Materials and Methods:
All the cases newly diagnosed as myeloid neoplasms during this period were included in the study. Clinical features, and hematological and cytogenetic findings were compiled.

Statistical Analysis:
For categorical data, the number and percentage were used. The Chi-square (χ2) test was used for association between two categorical variables. If the P value was < 0.05, then the results were considered to be statistically significant. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) software v. 23 (IBM Statistics, Chicago, USA) and Microsoft Office 2007.

Results and Conclusion:
A total of 51 cases were observed during the study period. The cases ranged from 14 to 74 years with maximum cases occurring between 51 and 60 years with a male-to-female (M: F) ratio of 1:1.25. Among the 51 cases of myeloid neoplasms, 28 (55%) cases of MPN, 14 (27%) cases of AML, five (10%) cases of MDS, and four (8%) cases of MPN/MDS were observed in their decreasing frequency. The most common symptoms were constitutional symptoms, such as generalized weakness, easy fatigability, and fever. Bone marrow study played a major role in diagnosis. The cytogenetic study complemented the diagnosis. A high clinical suspicion along with a good morphological diagnosis using peripheral smear, bone marrow aspiration, and biopsy supplemented by special stains and molecular studies will enable early and efficient diagnosis of myeloid neoplasms.
Correlation of Immunohistochemical Expression of Alpha-Methyl Acyl-Coenzyme A Racemase/p504s with Gleason Grade and Serum PSA Level in Prostate Carcinoma
Authors: Gami Hina J. , Patil Vijayalaxmi S. , Patil Santosh R. , Jawalkar Sneha A. , Barate Shraddha S. 
Published: January 2025

ABSTRACT

Context:
Carcinoma of the prostate is the second most common cause of cancer in males. Alpha-methyl-acyl-CoA racemase (AMACR) is a diagnostic marker for prostatic carcinoma. There is a significant lack of studies relating to the immunohistochemical expression of AMACR in prostatic cancer tissue and its prognosis.

Aim:
To study the pattern of expression of AMACR in prostatic carcinoma on immunohistochemistry and its correlation with Gleason grade and serum prostate-specific antigen (PSA) level of patients.

Materials and Methods:
This was a prospective study of 45 cases of histopathologically diagnosed primary adenocarcinoma of prostate. Immunohistochemistry for AMACR was performed on tissue core biopsies, transurethral resection of the prostate (TURP) chips, and its expression was evaluated in relation to Gleason grade and PSA level. The data were statistically analyzed using the Chisquare test and unpaired t-test.

Results:
AMACR expression was noted in 42 (93.33%) cases of malignant lesions of the prostate. Statistically significant relation was obtained between high AMACR expression and high Gleason grade. No significance was noted between AMACR expression and serum PSA level.

Conclusion:
This study adds to an understanding of efficacy of immunoexpression of AMACR in prostate carcinoma. Strong AMACR expression is a poor prognostic indicator as it is associated with high Gleason grade in prostatic carcinomas.
Sources of Information on and Perceptions Related to Infant and Young Child Feeding among Fathers: A Cross-Sectional Study from Southern India
Authors: Mithra Prasanna , Unnikrishnan Bhaskaran , Rekha T , Kumar Nithin , Holla Ramesh 
Published: January 2025

ABSTRACT

Introduction:
The infant and young child feeding (IYCF) practices determine the well-being of the child. Reliable and updated information is essential to have adequate feeding practices for young children. This also applies to the fathers of children. The sources of information and related factors are crucial in improving paternal IYCF practices.

Methodology:
This study assessed the perceptions, preferred sources of information of the fathers regarding IYCF, and associated factors. This paper includes a part of the community-based cross-sectional phase from a larger multiphase study carried out among 450 fathers of young children (aged <2 years) in a rapidly developing coastal district of the South Indian State of Karnataka. Data were analyzed using Jamovi software version 2.3.26.

Results:
The age of the participants ranged from 23 to 56 (mean: 34.6 years +/- 5.4); 46.7% of participants preferred relatives and friends, and 38.9% preferred healthcare providers as sources of information on IYCF. Those residing in predominantly rural areas were more likely to consult health care providers for information on IYCF (OR 3.50 (95% CI 1.98–6.53; P < 0.001)). Also, 77.3% of participants felt weaning must be started after 6 months of age. Nearly half of the participants were aware of the exact nature of food items to be introduced during weaning of their child.

Conclusions:
A high proportion of the participants felt the need to update their knowledge of IYCF. Nearly one-third of them preferred healthcare providers as a source of information. Participants from predominantly rural areas preferred healthcare providers as compared to those from urban areas.
Comparison of Chromosomal Damage caused by Conventional and Digital Mammography in Human Peripheral Lymphocytes
Authors: Nourin S , Tamizh Selvan G , Vishakh R , Nalilu Suchetha K. , Shetty Shashi K. 
Published: January 2025

ABSTRACT

Background:
Mammography is a widely used technology preferred by doctors for the early detection of breast cancer. Underlying problems are identified in about three years and are considered the most efficient method. Full-field digital mammography uses less radiation, and the images are stored in a system where they can be reviewed and adjusted according to the user’s requirements. Conventional mammography has a higher radiation dose, and film storage is required. Ionizing radiation causes several biological effects, including chromosomal aberration, disorder, anomaly, mutation, etc. This led us to investigate the effectiveness of digital mammography over the conventional mammography instrument.

Materials and Methods:
Blood samples were obtained from 13 healthy donors, aliquot into three different vials. Each donor’s blood was separated into control, conventional, and digital groups, and the conventional and digital vials were exposed to soft radiation. After exposure, the aliquot samples were acclimatized to a normal physiological condition, and a CBMN assay was performed. A minimum of 2000 cells were scored from every sample group. The MN frequency in each group was estimated to assess DNA damage.

Result:
A significant increase in micronucleus formation was observed in cells irradiated with conventional mammography compared to digital mammography and the non-irradiated control group.

Conclusion:
The study concludes that conventional mammography had significantly higher DNA damage when compared to digital. The study favors digital mammography and its response to producing fewer DNA damages.
Small Mahler measures with bounds on the house and shortness
Authors: El-Serafy Salma , McKee James 
Published: January 2025

Abstract
We show that for any

$\varepsilon>0$

, the number of monic, reciprocal, length-

$5$

integer polynomials that have house at least

$1+\varepsilon $

is finite. The proof is algorithmic, and we are consequently able to compute a complete list (not imposing any bound on the degree) of small Mahler measures of length-

$5$

polynomials that have house at least

$1.01$

.
For larger lengths, the analogous finiteness statement is false, as we show by examples. For length

$6$

we show that if one also imposes an upper bound for the Mahler measure that is strictly below the smallest Pisot number

$\theta = 1.32471\cdots $

, and if the length

$6$

polynomial is a cyclotomic multiple of an irreducible polynomial, then the number of polynomials with house at least

$1+\varepsilon $

is finite.
We pursue these ideas to search opportunistically for small Mahler measures represented by longer polynomials. We find one new small measure.
We give an algorithm that finds all Salem numbers in an interval

$[a,b]$

that are the Mahler measure of an integer polynomial of length at most

$6$

, provided

$1<a \le b < \theta $

.
On Approximability of Steiner Tree in $\ell_p$-metrics
Authors: Fleischmann Henry , Gavva Surya Teja , S Karthik C. 
Published: January 2025

In the Continuous Steiner Tree problem (CST), we are given as input a set of points (called terminals) in a metric space and ask for the minimum-cost tree connecting them. Additional points (called Steiner points) from the metric space can be introduced as nodes in the solution. In the Discrete Steiner Tree problem (DST), we are given in addition to the terminals, a set of facilities, and any solution tree connecting the terminals can only contain the Steiner points from this set of facilities. Trevisan [SICOMP'00] showed that CST and DST are APX-hard when the input lies in the $\ell_1$-metric (and Hamming metric). Chleb\'ik and Chleb\'ikov\'a [TCS'08] showed that DST is NP-hard to approximate to factor of $96/95\approx 1.01$ in the graph metric (and consequently $\ell_\infty$-metric). Prior to this work, it was unclear if CST and DST are APX-hard in essentially every other popular metric. In this work, we prove that DST is APX-hard in every $\ell_p$-metric. We also prove that CST is APX-hard in the $\ell_{\infty}$-metric. Finally, we relate CST and DST, showing a general reduction from CST to DST in $\ell_p$-metrics.Comment: Abstract shortened. Journal version for TheoretiCS
RANCANGAN PENGOLAHAN LIMBAH CAIR INDUSTRI BATIK MENGGUNAKAN ELEKTROKOAGULASI UNTUK PARAMETER KADAR Cr DAN Pb
Authors: Yusuf Aris Maulana , Masyruroh Anis , Pangesti Frebhika Sri Puji 
Published: January 2025

Industri batik di Indonesia menimbulkan persoalan tersendiri dalam kaitan lingkungan, seperti pencemaran akibat proses produksi batik yaitu polutan logam berat Krom (Cr) dan Timbal (Pb) yang mengancam kesehatan manusia. Teknologi yang bisa digunakan dalam menekan adanya polutan logam berat yaitu membuat Instalasi Pengolahan Air Limbah (IPAL). Pada penelitian ini bertujuan merancang prototipe IPAL elektrokoagulasi sederhana dan mengetahui penurunan pada polutan Cr dan Pb. Bak IPAL terdiri dari 4 bak yaitu bak ekualisasi, bak reaktor, bak filtrasi, dan bak kontrol. Efisiensi penurunan kualaitas limbah cair batik menggunakan IPAL elektrokoagulasi yaitu pada hari pertama konsentrasi Cr di waktu 120 menit -42,85%, dan di waktu 240 menit 28,5 %, untuk penurunan Pb di waktu 120 menit -14%, dan di waktu 240 menit 0%. Untuk hari kedua konsentrasi Cr di waktu 120 menit 11,1% dan di waktu 240 menit 33,3%, untuk penurunan Pb di waktu 120 menit 3,8%, dan di waktu 240 menit 3,8%. Hasil uji perbedaan influent dan effluent limbah cair batik menggunakan software SPSS tidak terdapat nilai signifikan.
Gambaran Kekerasan Seksual dan Tingkat Kecemasan pada Mahasiswa di Manado
Authors: Panggabean Hendro Hasea , David Lydia E.V. , Pali Cicilia 
Published: January 2025

Kekerasan seksual merupakan fenomena yang sampai saat ini sering terjadi dan dapat terjadi dimana saja, termasuk di lingkungan perguruan tinggi. Mahasiswa merupakan salah satu komponen di perguruan tinggi yang dapat mengalami kekerasan seksual. Kekerasan seksual yang dialami dapat menyebabkan dampak psikologi pada korban, salah satunya kecemasan. Tujuan penelitian ini untuk mengetahui gambaran kekerasan seksual dan tingkat kecemasan pada mahasiswa di Manado. Metode penelitian ini menggunakan metode kuantitatif deskriptif dengan membagikan kuesioner bentuk kekerasan seksual dan kuesioner tingkat kecemasan dengan Self-Rating Anxiety Scale (SAS) yang telah dimodifikasi untuk kekerasan seksual. Sampel diambil dengan teknik simple random sampling dan terkumpul sebanyak 280 responden yang memenuhi kriteria inklusi yang pernah mengalami setidaknya satu bentuk kekerasan seksual. Hasil penelitian ini menunjukkan tingkat kecemasan pada 280 responden mahasiswa yaitu sebanyak 198 mahasiswa 70,7% mengalami tingkat kecemasan ringan, sebanyak 77 mahasiswa (27,5%) mengalami kecemasan sedang, dan sebanyak 5 mahasiswa (1,8%) mengalami kecemasan berat. Kesimpulannya pada mahasiswa yang mengalami kekerasan seksual cenderung mengalami tingkat kecemasan ringan.
Stratégies, Besoins et Attentes des Elèves en Education Sexuelle en Milieu Scolaire Dans le Cadre du Cours D’éducation a la Vie
Authors: Mushiya Monique , Musenga John 
Published: January 2025

Objectif: La présente étude visait à comprendre les stratégies, besoins et attentes des élèves en matière de l’éducation sexuelle en milieu scolaire dans le cours d’éducation à la vie en vue de contribuer à une éducation sexuelle saine.
Méthodologie: Elle opte pour l’approche qualitative par échantillonnage non probabiliste de convenance. Cette étude qualitative de type descriptif exploratoire est réalisée auprès des élèves de 2e et 3e année des humanités de l’école d’application de l’UPN. La collecte des données s’est faite de manière transversale au cours de la période allant de 10 Novembre 2023 au 19 Février 2024. Elle applique la méthode phénoménologique qui vise une description soignée et systématique de ce qui est perçu par les adolescents sur leur attente et besoins à l’éducation sexuelle en milieu scolaire.
Résultats: Il ressort via les entretiens avec les apprenants que les notions liées à la sexualité permettent de connaitre et protéger le corps; aider à la gestion des pulsions sexuelles, éviter des relations intimes précoces et entretenir l’hygiène corporelle et menstruelle, prévenir et/ou découvrir des Infections à transmission sexuelle. En ce qui concerne leur vécu scolaire, les adolescents révèlent que l’éducation sexuelle insuffisante en milieu scolaire intensifie l’ignorance et risque accru de contracter le sida voire l’abandon des études, ne pas enseigner la sexualité à l’école donnera place aux fausses croyances avec risque de perte de virginité, de conception précoce et/ou d’une exclusion scolaire. Les répondants déclarent que l’enseignement de qualité doit être fondé sur les vrais problèmes en matière de sexualité, décrient le déficit dans la communication pédagogique dont ils sont victimes en matière de l’éducation sexuelle et recommande selon nous une communication pédagogique et didactique limpide. Pour plus d’efficacité, les répondants préconisent l’utilisation de formules didactiques adéquates, prendre l’éducation sexuelle, comme une préoccupation à part entière pour permettre un bon encadrement. L’éducation sexuelle en milieu scolaire à Kinshasa et en RDC représente une réponse essentielle aux enjeux sanitaires, sociaux et éducatifs actuels.
Contribution Unique à la Théorie, à la Pratique et à la Politique : Cependant, pour que les stratégies mises en place soient efficaces, il est nécessaire d'adapter les contenus pédagogiques aux réalités sociales et culturelles, de former les enseignants et d’instaurer un dialogue ouvert entre les élèves, les parents, et les autorités éducatives. Les élèves attendent une approche qui les respecte, qui les informe et qui les prépare à faire face aux défis d’une société en mutation rapide. Il est donc crucial de continuer à sensibiliser, former et améliorer l’accès à une éducation sexuelle de qualité pour tous.