bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the Effect of Tool Temperature on Microstructure, Hardness, and Wear Behaviour of Aluminium 6061-T6 Alloy Welded by the Friction Stir Welding Process
Authors: Pita Mothibeli 
Published: May 2023

The friction stir welding (FSW) tool is a critical component to the success of the welding process. The aim of the paper is to investigate the effect of tool temperature on the microstructure and mechanical properties of the aluminium alloy during the friction stir welding process. The welding experiment was conducted at a tool rotational speed of 550 rpm, and tool temperature was measured with the increment of a 60 mm distance. Three different tool temperatures were obtained, and samples were characterised by scanning electron microscopy (SEM). The ASTM E384 standard was followed when conducting the Vickers hardness test, and material wear behaviour was tested using the ASTM G99 tribology testing standard. The results show that the tool temperature increases with distance during the FSW process (40.5, 46, and 54°C). A high tool temperature produces the weld butt with high mechanical properties (87.5 HV). The wear rate is low at a high tool temperature (

1.169
E
−
006

mm3/N/m).
Stability-Enhanced Ternary Solid Dispersions of Glyburide: Effect of Preparation Method on Physicochemical Properties
Authors: Barghi Leila , Vekalati Afshin , Jahangiri Azin 
Published: May 2023

Introduction. Limited aqueous solubility and subsequent poor absorption and low bioavailability are the main challenges in oral drug delivery. Solid dispersion is a widely used formulation strategy to overcome this problem. Despite their efficiency, drug crystallization tendency and poor physical stability limited their commercial use. To overcome this defect, ternary solid dispersions of glyburide: sodium lauryl sulfate (SLS) and polyethylene glycol 4000 (PEG), were developed using the fusion (F) and solvent evaporation (SE) techniques and subsequently evaluated and compared. Materials and Methods. Physicochemical and dissolution properties of the prepared ternary solid dispersions were evaluated using differential scanning calorimetry (DSC), infrared spectroscopy (FTIR), and dissolution test. Flow properties were also assessed using Carr’s index and Hausner’s ratio. The physical stability of the formulations was evaluated initially and after 12 months by comparing dissolution properties. Results. Formulations prepared by both methods similarly showed significant improvements in dissolution efficiency and mean dissolution time compared to the pure drug. However, formulations that were prepared by SE showed a greater dissolution rate during the initial phase of dissolution. Also, after a 12-month follow-up, no significant change was observed in the mentioned parameters. The results of the infrared spectroscopy indicated that there was no chemical interaction between the drug and the polymer. The absence of endotherms related to the pure drug from thermograms of the prepared formulations could be indicative of reduced crystallinity or the gradual dissolving of the drug in the molten polymer. Moreover, formulations prepared by the SE technique revealed superior flowability and compressibility in comparison with the pure drug and physical mixture (ANOVA,

P

<

0.05

). Conclusion. Efficient ternary solid dispersions of glyburide were successfully prepared by F and SE methods. Solid dispersions prepared by SE, in addition to increasing the dissolution properties and the possibility of improving the bioavailability of the drug, showed acceptable long-term physical stability with remarkably improved flowability and compressibility features.
Associations of Race and Ethnicity with Hepatocellular Carcinoma, Decompensation, and Mortality in US Veterans with Cirrhosis
Authors: VoPham Trang , Cravero Anne , Feld Lauren D. , Green Pamela , Feng Ziding , Berry Kristin , Kim Nicole J. , Vutien Philip , Mendoza Jason A. , Ioannou George N. 
Published: May 2023

Abstract

Background:
Among patients with cirrhosis, it remains unclear whether there are racial/ethnic differences in cirrhosis complications and mortality. We examined the associations between race/ethnicity and risk for hepatocellular carcinoma (HCC), cirrhosis decompensation, and all-cause mortality overall and by cirrhosis etiology.

Methods:
US Veterans diagnosed with cirrhosis from 2001 to 2014 (n = 120,992), due to hepatitis C virus (HCV; n = 55,814), alcohol-associated liver disease (ALD; n = 36,323), hepatitis B virus (HBV; n = 1,972), nonalcoholic fatty liver disease (NAFLD; n = 17,789), or other (n = 9,094), were followed through 2020 for incident HCC (n = 10,242), cirrhosis decompensation (n = 27,887), and mortality (n = 81,441). Multivariable Cox proportional hazards regression was used to estimate adjusted hazard ratios (aHR) and 95% confidence intervals (CI).

Results:
Compared with non-Hispanic White patients, Hispanic patients had higher risk for HCC overall (aHR, 1.32; 95% CI, 1.24–1.41) and by cirrhosis etiology, particularly for ALD- (aHR, 1.63; 95% CI, 1.42–1.87) and NAFLD-cirrhosis (aHR, 1.76; 95% CI, 1.41–2.20), whereas non-Hispanic Black patients had lower HCC risk in ALD- (aHR, 0.79; 95% CI, 0.63–0.98) and NAFLD-cirrhosis (aHR, 0.54; 95% CI, 0.33–0.89). Asian patients had higher HCC risk (aHR, 1.70; 95% CI, 1.29–2.23), driven by HCV- and HBV-cirrhosis. Non-Hispanic Black patients had lower risk for cirrhosis decompensation overall (aHR, 0.71; 95% CI, 0.68–0.74) and by cirrhosis etiology. There was lower risk for mortality among all other racial/ethnic groups compared with non-Hispanic White patients.

Conclusions:
Race/ethnicity is an important predictor for risk of developing HCC, decompensation, and mortality.

Impact:
Future research should examine factors underlying these racial/ethnic differences to inform prevention, screening, and treatment for patients with cirrhosis.
Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade
Authors: Hong Dong-Chun , Yang Jing , Sun Cong , Liu Yuan-Tao , Shen Lu-Jun , Xu Bu-Shu , Que Yi , Xia Xiaojun , Zhang Xing 
Published: May 2023

Abstract

Purpose:
Radiation-induced sarcomas (RIS) have a poor prognosis and lack effective treatments. Its genome and tumor microenvironment are not well characterized and need further exploration.

Experimental Design:
Here, we performed whole-exome sequencing (WES) and mRNA sequencing (mRNA-seq) on patients with RIS and primary sarcomas (WES samples 46 vs. 48, mRNA-seq samples 16 vs. 8, mainly in head and neck), investigated the antitumor effect of programmed cell death protein 1 (PD-1) blockade in RIS patient-derived xenograft models, and analyzed clinical data of patients with RIS treated with chemotherapy alone or combined with an anti–PD-1 antibody.

Results:
Compared with primary sarcomas, RIS manifested different patterns of copy-number variations, a significantly higher number of predicted strong MHC-binding neoantigens, and significantly increased immune cell infiltration. Clinical data showed that the combinatorial use of chemotherapy and PD-1 blockade achieved a higher objective response rate (36.67% vs. 8.00%; P = 0.003), longer overall survival (31.9 months vs. 14.8 months; P = 0.014), and longer progression-free survival (4.7 months vs. 9.5 months; P = 0.032) in patients with RIS compared with single chemotherapy.

Conclusions:
Elevated genomic instability and higher immune cell infiltrations were found in RIS than in primary sarcomas. Moreover, higher efficacy of chemotherapy plus PD-1 blockade was observed in animal experiments and clinical practice. This evidence indicated the promising application of immune checkpoint inhibitors in the treatment of RIS.
A Molecular Blueprint to Targeting ALK Gene Fusions in Glioblastoma
Authors: Mack Stephen C. , Bertrand Kelsey C. 
Published: May 2023

Summary
Glioblastoma (GBM) is a heterogeneous brain tumor entity from infancy through adulthood. ALK gene fusions enriched in congenital and infant GBM have emerged as druggable driver alterations. Understanding the molecular basis and prevalence of ALK gene rearrangements will help define patients with GBM who may benefit from ALK-targeted therapy.
See related article by Blandin et al., p. 2651
Efficient Decoding of Compositional Structure in Holistic Representations
Authors: Kleyko Denis , Bybee Connor , Huang Ping-Chen , Kymn Christopher J. , Olshausen Bruno A. , Frady E. Paxon , Sommer Friedrich T. 
Published: May 2023

Abstract
We investigate the task of retrieving information from compositional distributed representations formed by hyperdimensional computing/vector symbolic architectures and present novel techniques that achieve new information rate bounds. First, we provide an overview of the decoding techniques that can be used to approach the retrieval task. The techniques are categorized into four groups. We then evaluate the considered techniques in several settings that involve, for example, inclusion of external noise and storage elements with reduced precision. In particular, we find that the decoding techniques from the sparse coding and compressed sensing literature (rarely used for hyperdimensional computing/vector symbolic architectures) are also well suited for decoding information from the compositional distributed representations. Combining these decoding techniques with interference cancellation ideas from communications improves previously reported bounds (Hersche et al., 2021) of the information rate of the distributed representations from 1.20 to 1.40 bits per dimension for smaller codebooks and from 0.60 to 1.26 bits per dimension for larger codebooks.
Deep Clustering With a Constraint for Topological Invariance Based on Symmetric InfoNCE
Authors: Zhang Yuhui , Wada Yuichiro , Waida Hiroki , Goto Kaito , Hino Yusaku , Kanamori Takafumi 
Published: May 2023

Abstract
We consider the scenario of deep clustering, in which the available prior knowledge is limited. In this scenario, few existing state-of-the-art deep clustering methods can perform well for both noncomplex topology and complex topology data sets. To address the problem, we propose a constraint utilizing symmetric InfoNCE, which helps an objective of the deep clustering method in the scenario of training the model so as to be efficient for not only noncomplex topology but also complex topology data sets. Additionally, we provide several theoretical explanations of the reason that the constraint can enhances the performance of deep clustering methods. To confirm the effectiveness of the proposed constraint, we introduce a deep clustering method named MIST, which is a combination of an existing deep clustering method and our constraint. Our numerical experiments via MIST demonstrate that the constraint is effective. In addition, MIST outperforms other state-of-the-art deep clustering methods for most of the commonly used 10 benchmark data sets.
A Rapid Intensification Deterministic Ensemble (RIDE) for the Joint Typhoon Warning Center’s Area of Responsibility
Authors: Knaff John A. , Sampson Charles R. , Brammer Alan , Slocum Christopher J. 
Published: May 2023

Abstract
The Rapid Intensification Deterministic Ensemble (RIDE) is an operational method used to estimate the probability of tropical cyclone rapid intensification in the Joint Typhoon Warning Center’s area of responsibility. Inputs to RIDE are current intensity, storm latitude, intensity change forecasts from seven routinely available operational deterministic models of intensity change, and the number of those models exceeding their individual 90th percentile of intensity change. Deterministic model inputs come from four numerical weather prediction models, two statistical–dynamical models, and one purely statistical model. In RIDE, logistic regression combines the deterministic inputs to form a probabilistic rapid intensification forecast model. RIDE then also generates deterministic intensity forecasts from these probabilistic forecasts that serve as forecaster guidance and as input to intensity consensus aids. Results based on a year of independent verification suggest good reliability and discrimination with a general tendency to underpredict rapid intensification events, but with few false alarms.

Significance Statement
An operational tropical cyclone forecaster makes a forecast with deterministic and probabilistic intensity guidance tools at their disposal. These models have a varying degree of abilities for predicting both intensity change and rapid intensification. The forecaster faces a dilemma in how to combine this disparate guidance to anticipate rapid intensification events. Here, the RIDE model provides probability forecasts associated with rapid intensification at 12-, 24-, 36-, 48-, and 72-h lead times and associated deterministic forecasts. RIDE provides skillful rapid intensification forecasts and helps rectify this forecast dilemma.
Boring But Demanding: Using Secondary Tasks to Counter the Driver Vigilance Decrement for Partially Automated Driving
Authors: Mishler Scott , Chen Jing 
Published: May 2023

Objective We investigated secondary–task–based countermeasures to the vigilance decrement during a simulated partially automated driving (PAD) task, with the goal of understanding the underlying mechanism of the vigilance decrement and maintaining driver vigilance in PAD. Background Partial driving automation requires a human driver to monitor the roadway, but humans are notoriously bad at monitoring tasks over long periods of time, demonstrating the vigilance decrement in such tasks. The overload explanations of the vigilance decrement predict the decrement to be worse with added secondary tasks due to increased task demands and depleted attentional resources, whereas the underload explanations predict the vigilance decrement to be alleviated with secondary tasks due to increased task engagement. Method Participants watched a driving video simulating PAD and were required to identify hazardous vehicles throughout the 45-min drive. A total of 117 participants were assigned to three different vigilance-intervention conditions including a driving-related secondary task (DR) condition, a non-driving-related secondary task (NDR) condition, and a control condition with no secondary tasks. Results Overall, the vigilance decrement was shown over time, reflected in increased response times, reduced hazard detection rates, reduced response sensitivity, shifted response criterion, and subjective reports on task-induced stress. Compared to the DR and the control conditions, the NDR displayed a mitigated vigilance decrement. Conclusion This study provided convergent evidence for both resource depletion and disengagement as sources of the vigilance decrement. Application The practical implication is that infrequent and intermittent breaks using a non-driving related task may help alleviate the vigilance decrement in PAD systems.
Death Anxiety and Associated Factors Among Oncology Nurses and Physicians
Authors: Alhusamiah Bushra , Zeilani Ruqayya S. 
Published: May 2023

Background: Providing care for dying patients is a stress-inducing, complicated, as well as essential responsibility for health care providers. Furthermore, end-of-life care is associated with intense personal emotions such as grief, anxiety, depression, frustration, and guilt. Moreover, caring for terminally ill patients is a challenging task that confronts physicians and nurses with the psychological concerns of dealing with death, which is accompanied by a high level of physical and psychological discomfort. Objective: This study was aimed to measure the level of death anxiety among oncology nurses and physicians and to determine the associated factors that influence their level of death anxiety. Method: A cross-sectional descriptive design was used to guide this study, a non-probability convenience sampling method was used to recruit 200 oncology nurses and physicians from one specialized cancer center in Jordan. Data were collected using an electronic self-reported questionnaire include demographic data sheet and Collett-Lester fear of death scale, as well as all participants were invited via email for voluntary participation in this study. Result: The results revealed that the oncology nurses and physicians exhibited a moderate levels of death anxiety (CLDFODS = 91.07), furthermore, the result showed that female nurses and physicians exhibited a higher level of anxiety than male. Further, there were statistically significant differences in nurses’ and physicians’ level of death anxiety according to years of experience, receiving previous education on death and dying, and religious beliefs. On the other hand, there is no statistically significant differences in nurses’ and physicians’ level of death anxiety based on present or previous experience with loss of someone close to them. Conclusion: Jordanian oncology Nurses and physicians exhibited a moderate levels of death anxiety and fear of death, therefore, they have to address the inevitability of mortality since they are caring for dying patients frequently. They have to understand and acknowledge their thoughts regarding death and dying, as well as their death anxiety level before interacting with dying patients.
The effectiveness of occupational therapy supporting return to work for people who sustain serious injuries or develop long-term (physical or mental) health conditions: A systematic review
Authors: De Dios Perez Blanca , McQueen Jean , Craven Kristelle , Radford Kate , Blake Holly , Smith Benjamin , Thomson Louise , Holmes Jain 
Published: May 2023

Introduction: People with long-term conditions or recovering from serious injuries can struggle to return to work. The evidence for occupational therapy supporting return to work is limited. We aimed to identify and explain how occupational therapy interventions work. Methods: Systematic review. Seven databases were searched between 1 January 1980 and 15 June 2022. Studies measuring work-related outcomes among individuals receiving occupational therapy during absence from paid work were included. Multiple reviewers independently contributed to screening, quality appraisal and data extraction processes. Data were analysed as a narrative. Results: Twenty studies with 3866 participants were included; 17 were assessed as having high risk of bias. Occupational therapy was inconsistently acknowledged affecting study identification and occupational therapy components were poorly described. Meta-analysis was unfeasible due to outcome heterogeneity. Individually tailored occupational therapy focused on return to work in musculoskeletal conditions indicated the most promising outcomes. Key intervention components included vocational assessment, goal setting and self-management. Key mechanisms of action included early intervention, individualised support and being responsive to needs. Conclusion: Occupational therapists’ contributions supporting return to work should be clearly attributed. Future effectiveness research should standardise the measurement of work outcomes to support meta-analysis. Developing a taxonomy for occupational therapy supporting return to work could facilitate comparisons across studies, highlighting occupational therapists’ roles and facilitating training and benefits to patients.
Reliability of Magnetic Resonance Imaging Criteria for the Preoperative Assessment of Rotator Cuff Tears: A Systematic Review
Authors: Adriani Marco , Saccomanno Maristella Francesca , Motta Marcello , Galli Stefano , Milano Giuseppe 
Published: May 2023

Background: Magnetic resonance (MR) imaging is the most common modality for assessment of the rotator cuff before and after surgery. Several classifications have been described aiming to define main tear characteristics. However, there is still confusion when it comes to the reliability of those classifications. Purpose: (1) To identify all MR classifications available in the literature for preoperative assessment of rotator cuff tears, (2) to summarize available data on the reliability of identified classifications, and (3) to assess the methodological quality of reliability studies. Study Design: Systematic review; Level of evidence, 4. Methods: This systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. All studies reporting MR assessment in patients with a superior or posterosuperior rotator cuff tear were included. After identification of the available MR criteria, reliability studies were analyzed. Descriptive statistics were used to summarize findings. Methodological quality was assessed using the Quality Appraisal of Reliability Studies checklist. Results: A total of 75 studies were included in this review. Eight categories of outcomes could be identified. Of the total, 62 studies reported interobserver reliability whereas 32 reported intraobserver reliability of some of the identified criteria. Each category reflected a variety of reliability, ranging from poor to excellent agreement. MR proved to be a reliable imaging modality to detect the structural integrity of the posterosuperior cuff, especially in cases of full-thickness tear; it was also reliable in terms of tear width and length and muscle atrophy based on a tangent sign or Thomazeau classification. All other classifications did not prove acceptable reliability. Methodological quality was high for 23 articles and moderate for 14. Conclusion: Preoperative MR is a reliable imaging modality to identify full-thickness tears, measure tear size and morphology, and identify muscle atrophy with tangent sign or Thomazeau classification. All other outcomes and classifications did not show acceptable reliability; therefore, caution is needed when using them for preoperative evaluation of a rotator cuff tear.
Biomechanical Comparison of Distal Biceps Tendon Repair Techniques: Extracortical Single-Button Inlay Fixation Versus Intracortical Double-Button Onlay Anatomic Footprint Fixation
Authors: Ernstbrunner Lukas , Almond Mitchell , Rupasinghe Harshi S. , Jo Olivia I. , Zbeda Robert M. , Ackland David C. , Ek Eugene T. 
Published: May 2023

Background: Extracortical single-button (SB) inlay repair is a commonly used distal biceps tendon technique. However, complications (eg, neurovascular injury) and nonanatomic repairs have led to the development of intracortical fixation techniques. Purpose: To compare the biomechanical stability of extracortical SB repair with an anatomic intracortical double-button (DB) repair technique. Study Design: Controlled laboratory study. Methods: The distal biceps tendon was transected in 18 cadaveric elbows from 9 donors. One elbow of each donor was randomly assigned to the extracortical SB or anatomic DB group. Both groups were cyclically loaded with 60 N over 1000 cycles between 90° of flexion and full extension. The elbow was then fixed in 90° of flexion and the repair construct loaded to failure. Gap formation and construct stiffness during cyclic loading and ultimate load to failure were analyzed. Results: When compared with the extracortical SB technique after 1000 cycles, the anatomic DB technique showed significantly less gap formation (mean ± SD, 2.7 ± 0.8 vs 1.5 ± 0.9 mm; P = .017) and significantly more construct stiffness (87.4 ± 32.7 vs 119.9 ± 31.6 N/mm; P = .023). Ultimate load to failure was not significantly different between the groups (277 ± 93 vs 285 ± 135 N; P = .859). The failure mode in the anatomic DB group was significantly different from that of the extracortical SB technique ( P = .002) and was due to fracture avulsion of the cortical button in 7 of 9 specimens (vs none in the SB group). Conclusion: Our study shows that the intracortical DB technique produces equivalent or superior biomechanical performance to that of the SB technique. The DB technique may offer a clinically viable alternative to the SB repair technique. Clinical Relevance: This study suggests, at worst, an equivalent and, at best, a superior biomechanical performance of intracortical anatomic DB footprint repair at the time of surgery. However, the mode of failure suggests that this technique should not be used in patients with poor bone quality.