bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of a symmetric V‐shaped canyon on the seismic response of an adjacent building under oblique incident SH waves
Authors: Zhang Ning , Lu Haijun , Gao Yufeng , Dai Denghui , Zhang Yu , Pak Ronald Y.S. 
Published: February 2023

AbstractTo elucidate whether an irregular topography affects the seismic response of nearby structures, an analytical solution to the dynamic interaction between a symmetric V‐shaped canyon and an adjacent building under the incidence of SH waves is proposed by using the wave function expansion method. The dynamic canyon‐soil‐structure interaction is decomposed into two problems of scattering and radiation. The building is idealized as a shear wall supported by a semicircular rigid foundation. The analytical solution can be degenerated theoretically to the canonical model of a shear wall embedded in a half‐space for either a zero depth‐to‐width ratio of the canyon or an infinite canyon‐building distance. Through a numerical comparison with two past exact solutions to the sole shear wall model as well as the sole V‐shaped canyon model, the correctness of the method in this paper is verified. A systematic parametrical analysis in both frequency and time domains is performed. It is found that the seismic response of the building may be amplified when it is on the wave‐facing side of the canyon. The degree of amplification is closely related to the size and depth‐to‐width ratio of canyon, the wave velocity of half‐space, and the incident angle and frequency content of seismic waves. The potential adverse effects of the V‐shaped canyon on the ground motion input of adjacent buildings should be considered in the seismic design.
Preparation of milk‐based probiotic lactic acid bacteria biofilms: A new generation of probiotics
Authors: Rezaei Zeinab , Salari Amir , Khanzadi Saeid , Rhim Jong‐Whan , Shamloo Ehsan 
Published: February 2023

AbstractBiofilm is considered as a community of microorganisms in which cells adhere to each other on surfaces in a self‐produced matrix of extracellular polymer compounds. In recent years, efforts to use the beneficial aspects of biofilm in probiotic research have intensified. In this study, probiotic biofilms of Lactiplantibacillus plantarum and Lacticaseibacillus rhamnosus were manufactured using milk and transferred to yogurt in whole and pulverized forms to test in real food conditions. Survival was assessed during 21 days of storage time as well as gastrointestinal conditions. The results indicated that Lp. plantarum and Lc. rhamnosus can form a very desirable and strong biofilm that can have a good protective effect on the survival of these bacteria in probiotic yogurt during processing, storage, and gastrointestinal conditions, in a way that, after 120 min of treatment in high acidic gastrointestinal conditions (pH 2.0), the survival rate decreased by only 0.5 and 1.1 log CFU/ml. Probiotic biofilm can be used as a natural way of utilizing bacteria in biotechnology and fermentation, which is an excellent way to increase the utility of probiotics.
Neurotoxicity of ischemic astrocytes involves STAT3‐mediated metabolic switching and depends on glycogen usage
Authors: Borbor Mina , Yin Dongpei , Brockmeier Ulf , Wang Chen , Doeckel Marius , Pillath‐Eilers Matthias , Kaltwasser Britta , Hermann Dirk M. , Dzyubenko Egor 
Published: February 2023

AbstractAstrocytic responses are critical for the maintenance of neuronal networks in health and disease. In stroke, reactive astrocytes undergo functional changes potentially contributing to secondary neurodegeneration, but the mechanisms of astrocyte‐mediated neurotoxicity remain elusive. Here, we investigated metabolic reprogramming in astrocytes following ischemia–reperfusion in vitro, explored their role in synaptic degeneration, and verified the key findings in a mouse model of stroke. Using indirect cocultures of primary mouse astrocytes and neurons, we demonstrate that transcription factor STAT3 controls metabolic switching in ischemic astrocytes promoting lactate‐directed glycolysis and hindering mitochondrial function. Upregulation of astrocytic STAT3 signaling associated with nuclear translocation of pyruvate kinase isoform M2 and hypoxia response element activation. Reprogrammed thereby, the ischemic astrocytes induced mitochondrial respiration failure in neurons and triggered glutamatergic synapse loss, which was prevented by inhibiting astrocytic STAT3 signaling with Stattic. The rescuing effect of Stattic relied on the ability of astrocytes to utilize glycogen bodies as an alternative metabolic source supporting mitochondrial function. After focal cerebral ischemia in mice, astrocytic STAT3 activation was associated with secondary synaptic degeneration in the perilesional cortex. Inflammatory preconditioning with LPS increased astrocytic glycogen content, reduced synaptic degeneration, and promoted neuroprotection post stroke. Our data indicate the central role of STAT3 signaling and glycogen usage in reactive astrogliosis and suggest novel targets for restorative stroke therapy.
Chemoprevention of oral cancer: A review and future perspectives
Authors: Liao Yu‐Hao , Chou Wei‐Yi , Chang Chun‐Wei , Lin Mei‐Chun , Wang Cheng‐Ping , Lou Pei‐Jen , Chen Tseng‐Cheng 
Published: February 2023

AbstractBackgroundOral cancer causes significant morbidity and mortality. Chemoprevention utilizes medication or natural compounds to reverse oral premalignant lesions and to prevent second primary tumors.MethodsA comprehensive PubMed database and Cochrane Library search from 1980 to 2021 was performed using the keywords “leukoplakia,” “oral premalignant lesion,” and “chemoprevention.”ResultsChemopreventive agents included retinoids, carotenoids, cyclooxygenase inhibitor, herbal extracts, bleomycin, tyrosine kinase inhibitors, metformin, and immune checkpoint inhibitors. Although some agents demonstrated effect in reducing premalignant lesions and preventing second primary tumors, the results among different studies were highly variable.ConclusionsThe results of different trials, albeit inconsistent, provided substantial information for future studies. In the era of personalized medicine, future studies will focus on identifying specific biomarkers and molecular profile to monitor and to prevent malignant transformation. Larger trials are warranted to validate the effect of chemopreventive agents.
The association of patient‐reported social determinants of health and hospitalization rate: A scoping review
Authors: Ardekani Ali , Fereidooni Reza , Heydari Seyed Taghi , Ghahramani Sulmaz , Shahabi Saeed , Bagheri Lankarani Kamran 
Published: February 2023

AbstractIntroductionThe interplay between social determinants of health (SDOH) and hospitalization is significant as targeted interventions can improve the social status of the individuals. This interrelation has been historically overlooked in health care. In the present study, we reviewed studies in which the association between patient‐reported social risks and hospitalization rate was assessed.MethodWe performed a scoping literature review of articles published until September 1, 2022 without time limit. We searched PubMed, Embase, Web of Science, Scopus, and Google Scholar to find relevant studies using terms representing “social determinants of health” and “hospitalization.” Forward and backward reference checking was done for the included studies. All studies that used patient‐reported data as a proxy of social risks to determine the association between social risks and hospitalization rates were included. The screening and data extraction processes were done independently by two authors. In case of disagreement, senior authors were consulted.ResultsOur search process retrieved a total of 14,852 records. After the duplicate removal and screening process, eight studies met the eligibility criteria, all of which were published from 2020 to 2022. The sample size of the studies ranged from 226 to 56,155 participants. All eight studies investigated the impact of food security on hospitalization, and six investigated economic status. In three studies, latent class analysis was applied to divide participants based on their social risks. Seven studies found a statistically significant association between social risks and hospitalization rates.ConclusionIndividuals with social risk factors are more susceptible to hospitalization. There is a need for a paradigm shift to meet these needs and reduce the number of preventable hospitalizations.
HPV‐induced host epigenetic reprogramming is lost upon progression to high‐grade cervical intraepithelial neoplasia
Authors: Herzog Chiara , Vavourakis Charlotte D. , Barrett James E. , Karbon Gerlinde , Villunger Andreas , Wang Jiangrong , Sundström Karin , Dillner Joakim , Widschwendter Martin 
Published: February 2023

AbstractThe impact of a pathogen on host disease can only be studied in samples covering the entire spectrum of pathogenesis. Persistent oncogenic human papilloma virus (HPV) infection is the most common cause for cervical cancer. Here, we investigate HPV‐induced host epigenome‐wide changes prior to development of cytological abnormalities. Using cervical sample methylation array data from disease‐free women with or without an oncogenic HPV infection, we develop the WID (Women's cancer risk identification)‐HPV, a signature reflective of changes in the healthy host epigenome related to high‐risk HPV strains (AUC = 0.78, 95% CI: 0.72‐0.85, in nondiseased women). Looking at HPV‐associated changes across disease development, HPV‐infected women with minor cytological alterations (cervical intraepithelial neoplasia grade 1/2, CIN1/2), but surprisingly not those with precancerous changes or invasive cervical cancer (CIN3+), show an increased WID‐HPV index, indicating the WID‐HPV may reflect a successful viral clearance response absent in progression to cancer. Further investigation revealed the WID‐HPV is positively associated with apoptosis (ρ = 0.48;P < .001) and negatively associated with epigenetic replicative age (ρ = −0.43;P < .001). Taken together, our data suggest the WID‐HPV captures a clearance response associated with apoptosis of HPV‐infected cells. This response may be dampened or lost with increased underlying replicative age of infected cells, resulting in progression to cancer.
Benjamin F. Cravatt III – Chemical Proteomics Trailblazer
Authors: Hang Howard C. 
Published: February 2023

AbstractThe advances in large‐scale bioanalytical methods and computational approaches have afforded tremendous insight into fundamental mechanisms of health and disease as well as provided new opportunities for therapeutic development. However, the majority of proteins in humans remain undrugged or lack chemical probes to explore their functions in vivo. The pioneering studies on activity‐based protein profiling (ABPP) by Ben Cravatt and his lab members have provided a systematic and generalizable approach to address this major challenge in chemical biology and drug discovery. Notably, the Cravatt laboratory paved the way for employing activity‐ and reactivity‐based chemical probes with quantitative proteomics to identify small molecule protein targets and discover unpredicted protein hot spots for native and synthetic ligands. Importantly, these chemical proteomic methods have revealed new protein targets and mechanisms of action for drug discovery and have been widely adopted by many other laboratories around the world to discover new biology and pharmacology. The recognition of Ben Cravatt as a co‐recipient of the 2022 Wolf Prize in Chemistry for this trailblazing work in chemical proteomics is most well‐deserved.
Centering on economic construction to stabilize general socioeconomic conditions while fully promoting economic recovery: Outlook, policy simulations, and reform implementation—A summary of the annual SUFE macroeconomic report (2022–2023)
Authors: Huang Kevin X. D. , Tian Guoqiang , Wang Xiaowen 
Published: February 2023

AbstractThe Chinese economy upheld a frail recovery in 2022 under the triple superposition of contraction of demand, disruption in supply, and weakening expectations, aggravated by unanticipated adverse shocks in the midst of global turmoil. Over the year, rising income uncertainty set off by the pandemic shock continued depressing household consumption and housing demand. Trade also saw slowing growth, along with consumption and investment, with sluggish residential investment awaiting policy stimulus to take force. Unemployment rate remained high, and was much higher for youth engendered by severe structural imbalances in the labor market. Local government debt burden worsened while revenue shrinking, only to exacerbate the local fiscal financial risk. It fared better on the price side. While growth in producer price index kept falling, consumer price index maintained steady growth. Renminbi depreciated against USD through fluctuations with larger swings, but the exchange rate remained in a manageable band. The Institute for Advanced Research‐China Macroeconomic Model projects the baseline growth rate in real gross domestic product to be 5.4% in 2023. We have also used the model to conduct alternative scenario analyses and policy simulations to assess the impacts of potential downside risks or favorable situations. Our findings call for a focus on economic construction with deepening reform and opening up more comprehensively and initiatively. Only by doing so can China spur market vitality, strengthen business confidence, and forge competitive advantages.
The effect of an Internet‐based cognitive behavioral therapy intervention on social support in disaster evacuees
Authors: Frenette Émilie , Ouellet Marie‐Christine , Guay Stéphane , Lebel Jessica , Békés Vera , Belleville Geneviève 
Published: February 2023

AbstractIntroductionBoth exposure to a natural disaster and psychological symptoms may lead to decreases in social support. Few studies have examined ways to improve social support among victims of natural disasters.AimsThe objective of the study was to assess emotional and tangible support following a 12‐session Internet‐based cognitive behavioral therapy (ICBT) targeting posttraumatic stress (PTS), insomnia, and depression symptoms and to examine the association between posttreatment symptoms and emotional and tangible support.Materials and MethodsOne hundred and seventy‐eight wildfire evacuees with significant PTS, depression and/or insomnia symptoms were given access to the ICBT. They completed questionnaires at pre‐ and posttreatment to measure social support and symptom severity.ResultsResults show that completion of the treatment led to an improvement in emotional support. Lower posttreatment PTS and insomnia symptoms were associated with higher posttreatment emotional support.ConclusionICBT may contribute to enhance emotional support through symptom improvement and probably more so when social support is address directly in treatment.
Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models
Authors: Henrot Pauline , Blervaque Léo , Dupin Isabelle , Zysman Maéva , Esteves Pauline , Gouzi Fares , Hayot Maurice , Pomiès Pascal , Berger Patrick 
Published: February 2023

AbstractSkeletal muscle wasting, whether related to physiological ageing, muscle disuse or to an underlying chronic disease, is a key determinant to quality of life and mortality. However, cellular basis responsible for increased catabolism in myocytes often remains unclear. Although myocytes represent the vast majority of skeletal muscle cellular population, they are surrounded by numerous cells with various functions. Animal models, mostly rodents, can help to decipher the mechanisms behind this highly dynamic process, by allowing access to every muscle as well as time‐course studies. Satellite cells (SCs) play a crucial role in muscle regeneration, within a niche also composed of fibroblasts and vascular and immune cells. Their proliferation and differentiation is altered in several models of muscle wasting such as cancer, chronic kidney disease or chronic obstructive pulmonary disease (COPD). Fibro‐adipogenic progenitor cells are also responsible for functional muscle growth and repair and are associated in disease to muscle fibrosis such as in chronic kidney disease. Other cells have recently proven to have direct myogenic potential, such as pericytes. Outside their role in angiogenesis, endothelial cells and pericytes also participate to healthy muscle homoeostasis by promoting SC pool maintenance (so‐called myogenesis–angiogenesis coupling). Their role in chronic diseases muscle wasting has been less studied. Immune cells are pivotal for muscle repair after injury: Macrophages undergo a transition from the M1 to the M2 state along with the transition between the inflammatory and resolutive phase of muscle repair. T regulatory lymphocytes promote and regulate this transition and are also able to activate SC proliferation and differentiation. Neural cells such as terminal Schwann cells, motor neurons and kranocytes are notably implicated in age‐related sarcopenia. Last, newly identified cells in skeletal muscle, such as telocytes or interstitial tenocytes could play a role in tissular homoeostasis. We also put a special focus on cellular alterations occurring in COPD, a chronic and highly prevalent respiratory disease mainly linked to tobacco smoke exposure, where muscle wasting is strongly associated with increased mortality, and discuss the pros and cons of animal models versus human studies in this context. Finally, we discuss resident cells metabolism and present future promising leads for research, including the use of muscle organoids.
Contribution of parvovirus B19 in suspected cases of measles/rubella in Osaka, Japan, between 2011 and 2021
Authors: Kaida Yuko , Kanbayashi Daiki , Kurata Takako , Mori Haruyo 
Published: February 2023

AbstractErythema infectiosum, caused by human parvovirus B19 (B19V), is difficult to diagnose by its clinical symptoms and is often misdiagnosed as measles or rubella. Timely confirmation of measles/rubella or other viral etiologies via laboratory tests can provide an accurate picture of the infection status, which can appropriate response. The purpose of this study was to determine the contribution of B19V as an etiological agent for fever‐rash in suspected cases of measles and rubella in Osaka Prefecture between 2011 and 2021. Of 1356 suspected cases, 167 were confirmed with measles and 166 with rubella using nucleic acid testing (NAT). Of the remaining 1023 cases, 970 from which blood specimens could be obtained were screened by real‐time polymerase chain reaction for B19V, from which 136 (14%) tested positive. Of the positives cases, 21% were young children (9 years and younger), while 64% were adults (20 years and older). Phylogenetic tree analysis showed that 93 samples belonged to genotype 1a. The importance of B19V in the etiology of fever‐rash illness was revealed in this study. The importance of laboratory diagnosis by NAT in maintaining the status of measles elimination and to eliminate rubella was reaffirmed.
Impact of biochar on the yield and nutritional quality of tomatoes (Solanum lycopersicum) under drought stress
Authors: Usman Muhammad , Ahmad Noman , Raza Waleed , Zhao Zhenhua , Abubakar Maria , Rehman Sami Ur , Ikram Sufian , Tariq Humna 
Published: February 2023

AbstractBACKGROUNDUndeviating climatic instabilities have increased the incidents of drought. Crop performance and yield attributes of tomatoes are negatively affected by drought stress. Biochar is an organic amendment that can increase crop yield and nutritional value under water‐deficient conditions by retaining water and providing nutrients (nitrogen, phosphorus, potassium, and other trace elements).RESULTSThe present study was designed to investigate the effects of biochar on tomato plant physiology, yield, and nutritional quality under deficit moisture regimes. Plants were subjected to two biochar levels (0.1% and 0.2%) and four moisture levels [100%, 70%, 60%, and 50% field capacities (FCs)]. Drought stress, especially 50D (50% FC), severely affected the plant morphology, physiology, yield, and fruit quality attributes. However, plants grown in biochar‐amended soil showed significant increase in the studied attributes. Plant height, root length, fresh and dry weight of root, the number of fruits per plant, fruit fresh and dry weight, ash percent, crude fat, crude fiber, crude protein, and lycopene contents were increased in plants grown in biochar‐amended soil under control and drought stress.CONCLUSIONBiochar at 0.2% application rate depicted a more pronounced increment in the studied parameters than 0.1% and can save 30% water without compromising tomato crop yield and nutritional value. © 2023 Society of Chemical Industry.
Osthole regulates N6‐methyladenosine‐modified TGM2 to inhibit the progression of rheumatoid arthritis and associated interstitial lung disease
Authors: Lin Xian , Chen Jian , Tao Cheng , Luo Lianxiang , He Juan , Wang Qingwen 
Published: February 2023

AbstractRheumatoid arthritis (RA) is an inflammatory autoimmune disease, and RA interstitial lung disease (ILD) is a severe complication of RA. This investigation aims to determine the effect and underlying mechanism of osthole (OS), which could be extracted from Cnidium, Angelica, and Citrus plants and evaluate the role of transglutaminase 2 (TGM2) in RA and RA‐ILD. In this work, OS downregulated TGM2 to exert its additive effect with methotrexate and suppress the proliferation, migration, and invasion of RA‐fibroblast‐like synoviocytes (FLS) by attenuating NF‐κB signaling, resulting in the suppression of RA progression. Interestingly, WTAP‐mediated N6‐methyladenosine modification of TGM2 and Myc‐mediated WTAP transcription cooperatively contributed to the formation of a TGM2/Myc/WTAP‐positive feedback loop through upregulating NF‐κB signaling. Moreover, OS could downregulate the activation of the TGM2/Myc/WTAP‐positive feedback circuit. Furthermore, OS restrained the proliferation and polarization of M2 macrophages to inhibit the aggregation of lung interstitial CD11b+ macrophages, and the effectiveness and non‐toxicity of OS in suppressing RA and RA‐ILD progression were verified in vivo. Finally, bioinformatics analyses validated the importance and the clinical significance of the OS‐regulated molecular network. Taken together, our work emphasized OS as an effective drug candidate and TGM2 as a promising target for RA and RA‐ILD treatment.
Peripheral Inflammation Links with the Severity of Clinical Phenotype in Spinocerebellar Ataxia 2
Authors: Vázquez‐Mojena Yaimeé , Rodríguez‐Córdova Yanetsy , Dominguez‐Barrios Yennis , León‐Arcia Karen , Miranda‐Becerra David , Gonzalez‐Zaldivar Yanetza , Guerra‐Bustillos Guillermo , Ziemann Ulf , Auburger Georg , Rodríguez‐Labrada Roberto , Robinson‐Agramonte María de los Ángeles , Velázquez‐Pérez Luis 
Published: February 2023

ABSTRACTBackgroundThe role of peripheral inflammation in spinocerebellar ataxia type 2 (SCA2) is unknown.ObjectiveThe objective of this study was to identify peripheral inflammation biomarkers and their relationship with the clinical and molecular features.MethodsBlood cell count–derived inflammatory indices were measured in 39 SCA2 subjects and their matched controls. Clinical scores of ataxia, nonataxia, and cognitive dysfunction were assessed.ResultsThe neutrophil‐to‐lymphocyte ratio (NLR), the platelet‐to‐lymphocyte ratio (PLR), the Systemic Inflammation Index (SII), and the Aggregate Index of Systemic Inflammation (AISI) were significantly increased in SCA2 subjects compared with controls. The increases in PLR, SII, and AISI were even observed in preclinical carriers. NLR, PLR, and SII were correlated with the Scale for the Assessment and Rating of Ataxia speech item score rather than with the total score. The NLR and SII were correlated with the nonataxia and the cognitive scores.ConclusionsPeripheral inflammatory indices are biomarkers in SCA2, which may help to design future immunomodulatory trials and advance our understanding of the disease. © 2023 International Parkinson and Movement Disorder Society.