bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of endocrine disrupting compounds present in food on the enzymatic activity of methionine synthase in neuronal cells
Authors: García-Cerón Gabriela , Solano-González Alba Fernanda , Bonilla-Brunner Andrea , Araiza-Olivera Daniela , Gutiérrez-Aguilar Manuel , Ramiro-Cortés Yazmin , Rosetti Marcos Francisco , Garcia-Arrazola Roeb 
Published: August 2023

Abstract

EDCs can target the nuclear hormone receptors (NHR) leading to changes in the reduced/oxidized ratio of metabolites related to the methionine synthase (MS) activity. As a result, DNA methylation patterns are altered, and epigenetic changes may take place. This mechanism proposal has been named as redox DNA methylation (RDM). In the present work, in vitro neuron cell cultures were exposed to the two most common varieties of EDCs reported in food: phthalates and bisphenol A (BPA). As a result, enzymatic activity of MS was reduced up to 3-fold in comparison to cultures that were not exposed to EDCs. Our results demonstrate that some endocrine disrupting compounds in food can significantly reduce the enzymatic activity of methionine synthase in neurons leading to possible epigenetic changes associated to neurocognitive conditions.
Built-in electric fields in heterostructured lamellar membrane with highly efficient charged mass rejection
Authors: Jiang Zhongyi , Chen Chongchong , Wu Xiaoli , Chen Jingjing , Liu Siyu , Wang Yongzheng , Wu Wenjia , Zhang Jie , Wang Jingtao 
Published: August 2023

Abstract
Separation membranes with homogeneous charge channels are the mainstream to reject the transport of charged mass by forming electrical double layer (EDL). However, the EDL often compresses effective transport space of solvent and weakens channel-ion interaction, hindering solvent transport and lowering ion rejection efficiency. Here, built-in electric fields (BIEFs) are constructed in lamellar membranes by directly assembling the heterostructured nanosheets, which contain alternate positively charged nanodomains and negatively charged nanodomains. We demonstrate that the built-in electric fields are perpendicular to horizontal channel and the direction switches alternately. This eliminates EDL effect and forces ions to repeatedly collide with the channel walls. Thus, highly efficient rejection for charged mass (salts, dyes, and organic acids/bases) and simultaneously ultrafast water transport are achieved under both forward osmosis and nanofiltration processes. Particularly, in real seawater nanofiltration at 2 bar, this membrane realizes a rejection of 99.4% for total salts with water permeance of 24.8 L m-2 h-1 bar-1. Such mass transport behavior is quite different from that in homogeneous charge channels. Furthermore, the ion transport behavior in 2D channels without EDL is elucidated by validating classic horizontal projectile motion model.
Time Domain Characteristic Analysis of Non-coupled PCNN
Authors: Deng Xiangyu , Yu HaiYue , Huang XiKai 
Published: August 2023

Abstract
The Pulse-Coupled Neural Network (PCNN) model is a multi-parameter neural network, the input-output characteristics are greatly affected by parameters setting. The traditional non-coupled PCNN model, which only uses the gray value as input, results in a certain inhibition of the network's pulse firing characteristics. In this paper, based on the traditional non-coupled PCNN model, from the perspective of system equations, the firing characteristics of the non-simplified uncoupled PCNN model with coupled linking term is studied, and the mathematical expressions for firing time and interval were summarized. By constructing different neighborhood linking weight matrix patterns, the impact of the linking weight matrix and coefficients on network characteristics was analyzed, and the constraint conditions for parameters aE, VE, and VF were provided. Finally, through experiments simulation, the correctness of the theoretical analysis is verified, providing theoretical support for researching on fully parameterized PCNN and the application of the studied model in image processing.
Epidemiological aspects of individuals with mental disorders in the referral system: the experience of a Community Mental Health Center in the northeast of Iran
Authors: Talebi Mahdi , Niroumand Shabnam , Gholami Mobin , Samarghandi Azadeh , Nemati Ahmad 
Published: August 2023

Abstract
Background
Community Mental Health Centers (CMHCs) provide mental health services to patients at low cost, with less stigma, in a domiciliary setting. This study aimed to assess the epidemiological and variety of mental disorders and treatment dropout among patients attending the only CMHC of Mashhad, northeastern Iran. Furthermore, the association of demographic variables with referral from primary health care centers was investigated.
Methods
This cross-sectional study enrolled 662 patients who contacted this center between January 2014 and December 2021. We completed a checklist that included information on demographics, diagnosed mental disorders, referral status, and the number of psychiatric visits, all of which psychiatrists fully completed clinical records. The frequency distributions of all variables were conducted with SPSS11.5. In addition, the association between epidemiological findings and patient referral (referral system or self-referral) and the association between epidemiological findings and the number of psychiatric revisits were examined by the Chi-square test.
Results
Of 662 patients, 472 (71%) women and 190 (29%) men were enrolled, and the mean age of all patients was 29 years. Among the 475 adult patients, 367 (77.3%) patients were married and had primary or secondary education (40.4%), and the majority of them were housewives (56.4%). Major Depression Disorder (32%), Generalized Anxiety Disorder (18.3%) were the two most common mental illnesses in patients. Most patients (70.7%) were referred to this center via the referral system. Moreover, non-working patients (housewives and unemployed patients) and the female gender were associated with more referrals to this center through the referral system. 431 patients (65.1%) did not return for a second visit, and the higher number of psychiatric visits was associated with a lower level of education.
Conclusions
It is recommended that primary health care centers (PHCs) undergo certain modifications to enhance the screening process for psychiatric patients, focusing on common mental disorders. Referral of mental illnesses to CMHCs should be taken more seriously, especially in women with low socioeconomic status. Better health services in CMHCs can encourage patients to continue treatment in CMHCs.
A Carrier-Free Supramolecular Nano-Twin-Drug for Overcoming Irinotecan- Resistance and Enhancing Efficacy against Colorectal Cancer
Authors: Yuan Miaomiao , Chen Tong , Jin Lu , Zhang Peng , Xie Luoyijun , Zhou Shuyi , Fan Lianfeng , Wang Li , Zhang Cai , Tang Ning , Guo Lihao , Xie Chengmei , Duo Yanhong , Li Ling , Shi Leilei 
Published: August 2023

Abstract
Irinotecan (Ir) is commonly employed as a first-line chemotherapeutic treatment for colorectal cancer (CRC). However, tremendous impediments remain to be addressed to surmount drug resistance and ameliorate adverse events. Poly-ADP-Ribose Polymerase (PARP) participates in the maintenance of genome stability and the repair of DNA damage, thus playing a critical role in chemotherapy resistance. In this work, we introduce a novel curative strategy which utilizes nanoparticles (NPs) prepared by dynamic supramolecular co-assembly of Ir and a PARP inhibitor (PARPi) niraparib (Nir) through π-π stacking and hydrogen bond interactions. The Ir and Nir self-assembled Nano-Twin-Drug of (Nir-Ir NPs) could enhance efficacy against CRC by synergistically inhibiting the DNA damage repair pathway and activating the tumor cell apoptosis process without obvious toxicity. In addition, the Nir-Ir NPs could effectively reverse irinotecan-resistance by inhibiting the expression of multiple resistance protein-1 (MRP-1). Overall, our study underscores the distinctive advantages and potential of Nir-Ir NPs as a complementary strategy to chemotherapy by simultaneously overcoming the Ir resistance and improving the anti-tumor efficacy against CRC.
Application of the Tight Binding Method onto the von-Neumann Equation
Authors: Abdi Alan , Schulz Dirk 
Published: August 2023

Abstract

This paper presents a numerical framework for the analysis of quantum devices based on the von-Neumann (VN) equation, which involves the concept of theTight Binding Method (TBM). The model is based on the application of the Tight Binding Hamiltonian within Quantum Liouville Type Equations and has the advantage that the atomic structure of the materials used is taken into account. Furthermore, the influence of a Complex Absorbing Potential and its essential contribution to the system stability with respect to the eigenvalue spectrum is discussed.
Optimize UAV reliability with a new hybrid approach
Authors: Boucerredj Leila , Meneceur Souhaila , Bouafia Abderrhmane 
Published: August 2023

Abstract
In this work, we propose a new hybrid approach to optimize the reliability of Unmanned Aerial Vehicles (UAV) based on two complementary approaches. The first approach is based on the Failure Mode and Effects Analysis (FMEA), which is an informal method based on the establishment of a table describing the failure modes of the elements of the system and their effects, the aim of using this method is to optimize the search of critical scenarios that leads the system to the failure state. The second approach is based on Developed Stochastic Petri nets formalism coupled with the reliability laws (RLSPNs) according to the nature of the components (electronic, electrical, mechanical, software, …etc.) of the system, this simplifies the reliability evaluation of the system components as well as the reliability of the complete system. The goal of this approach is to determine the main causes of the failure of the system, optimize the search of critical scenarios, and study the reliability of system components; in order to have the most reliable and least reliable components. This detailed study will certainly make it possible to propose improvements that can in the future improve the reliability of the complete system.
Inhibitory Control Training Improves Cold but Not Warm Cognition in Typically Developing Preschoolers
Authors: Nejati Vahid , Ghotbi Ladan , Raskin Sarah 
Published: August 2023

Abstract

Inhibitory control, as a fundamental executive function, has been found to be associated with a range of cognitive processes. In this study, our objective was to enhance inhibitory control through a targeted training program and assess its impact on delay discounting and risky decision making. Thirty-two typically-developing children (age mean 6.89 ± 0.32 years) were recruited in a random clinical trial design in two equal intervention and active control groups. Go/No-Go, Flanker, continuous performance, delay discounting, and balloon analogue risk tasks were used for assessment in three baseline, post- intervention, and 3-months follow-up sessions. The intervention group received the program for attentive rehabilitation of inhibition and selective attention (PARISA) and the active control group participated in a story telling class, both in 12 sessions. The results of the study indicate significant improvements in sustained attention, interference control, and prepotent inhibition among participants in the intervention group. However, there were no significant changes observed in delay discounting and risky decision making. These findings suggest that the inhibitory control training primarily enhances aspects of cold cognition and attentional processes. However, the observed improvements did not extend to reward processing or warm cognition.
Social cohesion in semi-public places: A study of Oude Noorde neighborhood in Rotterdam
Authors: Uka Gazmend 
Published: August 2023

Abstract

Lack of social cohesion in semi-public places is what this research is about. The main objective of this research is to see how semi-public places affect social cohesion in Oude Noorden, to identify barriers between different ethnic groups, and to explain the importance of semi-public places. In this research are analyzed two community centers, two mosques and are used secondary data from two public places in this neighborhood, the combination of data from public and semipublic places and synthesizing those data is what it makes different this study. More than half of Rotterdam's population is non-Dutch. Diversity in ethnicity, cultural, attitude, and lifestyle brings hipper diversity as a subject to describe differences. In recent decades, population mobility seeking benefits and secure locations to dwell has been facilitated by easy ways to relocate, wars, legislative changes, and numerous conflicts. As a result of this shift, the areas where immigrants live are residential neighborhoods. The Oude Noorden neighborhood in Rotterdam's north side has accepted a high number of emigrants. The first findings of this research are that not all places have the same importance and comprehension. Public places differ from semi-public places, and semi-public places differ in terms of social cohesion. Furthermore, semi-public places like schools, religious buildings, libraries, and community centers have a role in terms of social cohesion. Primary schools provide access only for limited ages, religious buildings have belief groups, and libraries usually are only for students, while community centers are comprehensive and give opportunities for people to contribute to social cohesion. To become a cohesive society those community centers must continue to rise their role in society.
Assessment of the relationship between colorectal cancer and systemic inflammatory regulators: a bidirectional Mendelian randomization study
Authors: Huang Yu-Liang , Li Min , Zheng Jin-Min , Shi Zheng-Yi , Chen Huan-Huan , Wang Xiao-Tong , Kong Fan-Biao 
Published: August 2023

Abstract
Background
Inflammation is intricately intertwined with cancer progression; however, the causal link between inflammatory factors and their propensity to either promote or mitigate colorectal cancer (CRC) remains substantively unexplored. In response to this knowledge gap, we undertook a bidirectional Mendelian randomization (MR) analysis, aimed at rigorously evaluating the causal relationship between 41 distinct genetic proxies representing inflammatory factors and the development of colorectal cancer.
Method
Cytokine levels were analyzed in a cohort of 8,293 individuals using data from a genome-wide association study (GWAS) focusing on exposures. Preliminary analysis made use of GWAS data related to colorectal cancer (CRC) obtained from the GWAS catalog database with accession number GCST012879. Causality analysis primarily employed the random inverse variance weighted (IVW) method, supplemented by MR-Egger and weighted median techniques. To enhance the study's robustness, sensitivity analyses encompassed the Cochran Q test, MR-Egger intercept test, MR-PRESSO, and leave-one-out analysis. Employing a comprehensive approach encompassing Mendelian Randomization, Linkage Disequilibrium Score Regression, and Colocalization Analysis, the study examined cytokines that exhibited statistical significance in the IVW analysis. Moreover, a Confounding Analysis was conducted to evaluate the direct impact of cytokines on CRC occurrence.
Result
The findings of this study demonstrate a significant association between Interferon-gamma (OR = 1.13, 95% CI = 1.01–1.28, p = 0.039), Tumor Necrosis Factor-beta (OR = 1.07, 95% CI = 1.01–1.14, p = 0.032), Interleukin-2 Receptor Alpha Subunit (OR = 0.93, 95% CI = 0.86–0.99, p = 0.035), and Stem Cell Factor (OR = 0.88, 95% CI = 0.79–0.98, p = 0.023) and CRC.
Conclusion
This study presents compelling evidence regarding the causal interplay between four specific inflammatory factors and colorectal cancer. Furthermore, the multifaceted analyses employed introduce fresh insights into our understanding of the role played by colorectal cancer. These discoveries hold promising implications for enhancing CRC screening, prevention, and therapeutic strategies.
Association between water, sanitation and hygiene practices and diarrhea among under 3-year-old children: Evidence from a nationally representative sample in India (2019–2021)
Authors: Roy Shubhanjali , Kiruthika G. , Muthappan Sendhilkumar , Rizwan S. A. , Kathiresan Jeyashree 
Published: August 2023

AbstractGlobally, 1.7 billion cases of childhood diarrheal disease occur every year. The Government of India initiated the Intensive Diarrhea Control Fortnight (IDCF) program in 2015 aimed to reduce childhood diarrheal deaths to zero. We aimed to ascertain the association between WASH practices and the prevalence of diarrhea in India's children under three years of age. We analyzed the data from the NFHS-5 survey conducted between 2019 and 2021. We extracted data on household and individual levels. The association between WASH practice in the household and diarrheal episodes in children &lt;3 years old were presented by unadjusted and adjusted prevalence ratio (PR) with a 95% confidence interval (CI). We used STATA v 16 for analysis. We included 132,198 children, 8.4% (n = 11,060) had diarrhea in the 2 weeks preceding the survey. The majority of the children were residing in rural areas (79.8%) and using unprotected water (90%) sources. Diarrhea was associated with using shared toilet facilities (adj. PR: 1.28, 95% CI: 1.17, 1.34), improper disposal of child's stools (adj. PR: 1.12, 95% CI: 1.05, 1.20) and having no separate kitchen (adj. PR: 1.16, 95% CI: 1.08, 1.23). Household WASH practices continue to be independent predictors of diarrhea among &lt;3 children.
Estimating the Survival Rate in Glioblastoma Multiforme Patients who Received a Peptide Vaccine: A Systematic Review and Meta-analysis
Authors: Dashtaki Masoumeh Eliyasi , Moradi Zahra , Moradi Yousef , Farsani Elham Asadi , Ghasemi Sorayya 
Published: August 2023

Introduction:Glioblastoma Multiforme (GBM) has a poor prognosis, with current treatments providing no advantage in terms of survival. Certain new immunotherapy methods, such as peptide vaccines, have been used in clinical trials. In this meta-analysis, the effectiveness of peptide vaccinations on the survival rate of GBM patients was studied.Methods:A comprehensive search was carried out using three electronic databases: PubMed, Scopus, and ISI. The purpose of this research was to assess Overall Survival (OS). The pooled overall one-year and two-year survival rates in GBM with peptide vaccination were calculated using the general inverse variance technique as random effects hazard ratios (HRs). In the study, subgroups of countries were compared with each other. Japan had the highest one-year survival rate, and the US had the highest two-year survival rate.Result:With 95% Confidence Intervals (CIs), the one-year OS rate in GBM patients treated with peptide vaccination increased significantly, but the two-year survival rate did not increase. As a result, while additional research is needed, it cannot be concluded that it is an effective therapy for GBM.Conclusion:Our study found that while peptide vaccination treatment did not increase second-year survival, it improved first-year survival. More research needs to be done to find effective vaccinebased treatments for GBM that can help patients survive longer.
MiR-148b Caused Liver Injury in Rats with Traumatic Hemorrhagic Shock by Inhibiting SIRT6 Expression
Authors: Ma Xiongfei , Liu Mingchen 
Published: August 2023

Background:
The purpose of this study was to investigate the role of miR-
148b in liver injury in rats with traumatic hemorrhagic shock (THS) and to elucidate its
potential mechanism.

Methods:
The levels of alanine aminotransferase (ALT) and aspartate aminotransferase
(AST) in the serum of rats were detected by enzyme-linked immune sorbent assay
(ELISA), and the injury of rat liver was analyzed by hematoxylin-eosin (H&E) staining.
Apoptosis of rat hepatocytes and normal rat liver cell line (BRL3A) was identified by
terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL)
assay and flow cytometry, respectively. MiR-148b and sirtuin 6 (SIRT6) expression was
measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR)
and Western blot. Lactate dehydrogenase (LDH) content and cell viability were
measured by commercial kits and cell counting kit-8 (CCK-8) assay, respectively. The
binding sites of miR-148b and SIRT6 were predicted by the Starbase database and
verified by dual luciferase reporter assay.

Results:
MiR-148b expression in THS rats or ischemia-reperfusion (I/R)-treated cells
was higher than in the control group. Overexpression of miR-148b further promoted the
effects of I/R, which enhanced the levels of ALT, AST and LDH, cell apoptosis of liver
tissue or BRL3A cells and decreased the expression of SITR6. Besides, miR-148b
negatively correlated with SIRT6, and upregulated the expression of SIRT6 could partly
reverse the effect of miR-148b.

Conclusion:
Hepatocyte injury induced by I/R was achieved by regulating miR-148b
/SIRT6 axis.
Intermittent Fasting against Cancer Development and Progression: Highlighting
Potential Anticancer Molecular Mechanisms
Authors: Psara Evmorfia , Poulios Efthymios , Papadopoulou Sousana K. , Tolia Maria , Vasios Georgios K. , Giaginis Constantinos 
Published: August 2023

Background:
Intermittent fasting (IF) diets have been popular since the last few decades because of their
provable clinical efficiency on weight control of the subjects. These diet types are generally safe, resulting in health
promoting effects against several human diseases like cardiovascular diseases, diabetes mellitus, neurogenerative disorders
and cancer.

Objective:
To review whether IF can act against cancer development and progression, highlighting potential anticancer
molecular mechanisms in clinical studies.

Methods:
Applied summarization of the available clinical studies investigating the effectiveness of IF against cancer
development and progression and cancer-induced indicators. Scientific databases, e.g., PubMed, and Scopus, were
comprehensively searched using relative words to identify in vivo and in vitro data, as well as clinical studies.

Results:
IF seems to exert health-promoting effects in cancer patients through induction of autophagy, which enhances
the in vivo suppression of tumor development, by chemotherapy. IF provokes tumors to chemotherapy and defends the
normal cells from its adverse side effects, increasing the immune response. In addition, it enhances the cytotoxic
CD8(+) tumor-infiltrating lymphocytes and the bone marrow lymphoid progenitor cells, delaying the cancer progression.
IF reduces oxidative stress via repression of translation and induces cellular apoptosis. Fasting exerts anti-aging
properties modulating the secretion of IGF-1, IGFBP-1, glucose, and insulin while, at the same time, it integrates cell
adaptive responses and activates cell signaling pathways which stimulates antioxidant defenses, DNA repairment,
control of protein quality, mitochondrial synthesis while decreasing inflammation.

Conclusion:
IF appears to exert health promoting effects against cancer development and progression, suppressing
several kinds of cancer. There are well-recognized and not well-recognized molecular processes accentuating its anticancer
outcomes; however, well-designed clinical trials and further molecular studies are strongly recommended.