bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teamwork solutions for complex problems in psychotherapy: A systems thinking‐based commentary
Authors: Botella Luis , Scherb Elena , Montesano Adrian 
Published: May 2023

AbstractIntroductionMost psychological treatments are administered in a one‐to‐one therapy format, which has proven effective but has limitations in complex clinical situations. Teamwork can help address these limitations by going beyond the one‐to‐one therapy approach and involving the client's professional and relational network in therapy interventions to promote and secure change. In this issue of Journal of Clinical Psychology: In Session five effective teamwork practices are presented illustrating how clinicians integrate teamwork into treatment delivery to improve outcomes in an array of cases presenting high complexity.PurposeIn this commentary section, we describe the role and essence of these teamwork practices from a systems thinking approach as a theoretical umbrella to understand the diversity of processes hindering and facilitating effective teamworkConclussionFrom this approach we discuss the core skills that psychotherapists should train to master team working and interprofessional collaboration. The basic professional competence consists in the ability to foster and coordinate shared frames of understanding in case formulation. An advanced systemic skill is based on the ability to formulate and change relational patterns, given that interpersonal processes are the main key factor to understand barriers and facilitators of effective teamwork to overcome stalemated complex clinical situations.
Milk protects against sarcopenic obesity due to increase in the genus Akkermansia in faeces of db/db mice
Authors: Okamura Takuro , Hamaguchi Masahide , Nakajima Hanako , Kitagawa Nobuko , Majima Saori , Senmaru Takafumi , Okada Hiroshi , Ushigome Emi , Nakanishi Naoko , Sasano Ryoichi , Fukui Michiaki 
Published: May 2023

AbstractBackgroundSarcopenic obesity, a combination of sarcopenia and obesity, is a pathological feature of type 2 diabetes. Several human studies have shown that milk is useful in the prevention of sarcopenia. This study was aimed at clarifying the effect of milk on the prevention of sarcopenic obesity in db/db mice.MethodsA randomized and investigator‐blinded study was conducted using male db/db mice. Eight‐week‐old db/db mice were housed for 8 weeks and fed milk (100 μL/day) using a sonde. The faecal microbiota transplantation (FMT) group received antibiotics for 2 weeks, starting at 6 weeks of age, followed by FMT twice a week until 16 weeks of age.ResultsMilk administration to db/db mice increased grip strength (Milk−: 164.2 ± 4.7 g, Milk+: 230.2 ± 56.0 g, P = 0.017), muscle mass (soleus muscle, Milk−: 164.2 ± 4.7 mg, Milk+: 230.2 ± 56.0 mg, P < 0.001; plantaris muscle, Milk−: 13.3 ± 1.2 mg, Milk+: 16.0 ± 1.7 mg, P < 0.001) and decreased visceral fat mass (Milk−: 2.39 ± 0.08 g, Milk+: 1.98 ± 0.04 mg, P < 0.001), resulting in a significant increase in physical activity (light: P = 0.013, dark: P = 0.034). FMT from mice fed milk not only improved sarcopenic obesity but also significantly improved glucose intolerance. Microarray analysis of gene expression in the small intestine revealed that the expression of amino acid absorption transporter genes, namely, SIc7a5 (P = 0.010), SIc7a1 (P = 0.015), Ppp1r15a (P = 0.041) and SIc7a11 (P = 0.029), was elevated in mice fed milk. In 16S rRNA sequencing of gut microbiota, the genus Akkermansia was increased in both the mice fed milk and the FMT group from the mice fed milk.ConclusionsThe findings of this study suggest that besides increasing the intake of nutrients, such as amino acids, milk consumption also changes the intestinal environment, which might contribute to the mechanism of milk‐induced improvement of sarcopenic obesity.
Valorization of brewery waste slurry with glycerol as co‐substrate for hydrogen and butyrate production using dark fermentation
Authors: Garduno Rafael , Baranova Elena , Kinsley Chris 
Published: May 2023

AbstractBACKGROUNDAmong the methods to produce hydrogen biologically, dark fermentation stands out mainly due to its low operating requirements. Organic wastes, such as brewing industry waste slurries and glycerol, can provide a cost‐effective feedstock with the additional potential of generating value‐added byproducts, while addressing a wastewater treatment issue.RESULTSThe hydrogen production potential in dark fermentation of a high‐strength brewery waste slurry was optimized with a selected seed sludge, initial COD concentration of 50–60 g L−1, pH 6.4 and fermentation time of 30 h. The main end product was butyric acid, accounting for over 50% of the carboxylic acids. The efficiency of the process on the basis of volume of H2 obtained per gram of COD converted into organic acids was 393 ± 5 and 430 ± 6 mL without and with glycerol, respectively, and the molar ratio of H2 per mole of substrate was 71% of the theoretical molar yield when the fermentation is dominated by butyrate as the end product.CONCLUSIONSA proposed brewery sludge treatment system comprising dark fermentation followed by anaerobic digestion is promising and can be more advantageous than anaerobic digestion alone with an increase of 18.5% in energy potential. Alternatively, with recovery of valuable butyrate, a reduction in 4.5 kg of CO2 emissions per cubic meter of sludge treated can be achieved, with a 27% net loss in energy potential. © 2023 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
Associating Peritoneal Metastasis With T2‐Weighted MRI Images in Epithelial Ovarian Cancer Using Deep Learning and Radiomics: A Multicenter Study
Authors: Wei Mingxiang , Zhang Yu , Ding Cong , Jia Jianye , Xu Haimin , Dai Yao , Feng Guannan , Qin Cai , Bai Genji , Chen Shuangqing , Wang Hong 
Published: May 2023

BackgroundThe preoperative diagnosis of peritoneal metastasis (PM) in epithelial ovarian cancer (EOC) is challenging and can impact clinical decision‐making.PurposeTo investigate the performance of T2‐weighted (T2W) MRI‐based deep learning (DL) and radiomics methods for PM evaluation in EOC patients.Study TypeRetrospective.PopulationFour hundred seventy‐nine patients from five centers, including one training set (N = 297 [mean, 54.87 years]), one internal validation set (N = 75 [mean, 56.67 years]), and two external validation sets (N = 53 [mean, 55.58 years] and N = 54 [mean, 58.22 years]).Field Strength/Sequence1.5 or 3 T/fat‐suppression T2W fast or turbo spin‐echo sequence.AssessmentResNet‐50 was used as the architecture of DL. The largest orthogonal slices of the tumor area, radiomics features, and clinical characteristics were used to construct the DL, radiomics, and clinical models, respectively. The three models were combined using decision‐level fusion to create an ensemble model. Diagnostic performances of radiologists and radiology residents with and without model assistance were evaluated.Statistical TestsReceiver operating characteristic analysis was used to assess the performances of models. The McNemar test was used to compare sensitivity and specificity. A two‐tailed P < 0.05 was considered significant.ResultsThe ensemble model had the best AUCs, outperforming the DL model (0.844 vs. 0.743, internal validation set; 0.859 vs. 0.737, external validation set I) and clinical model (0.872 vs. 0.730, external validation set II). After model assistance, all readers had significantly improved sensitivity, especially for those with less experience (junior radiologist1, from 0.639 to 0.820; junior radiologist2, from 0.689 to 0.803; resident1, from 0.623 to 0.803; resident2, from 0.541 to 0.738). One resident also had significantly improved specificity (from 0.633 to 0.789).Data ConclusionsT2W MRI‐based DL and radiomics approaches have the potential to preoperatively predict PM in EOC patients and assist in clinical decision‐making.Evidence Level4Technical EfficacyStage 2
Impact of cervicovaginal microbiome on the risk of cervical abnormalities development
Authors: Rosário Andreia , Sousa Ana , Varandas Tatiana , Marinho‐Dias Joana , Medeiros Rui , Martins Gabriela , Monteiro Paula , Sousa Hugo 
Published: May 2023

AbstractThe vaginal microbiome has emerged as potentially influencing the natural history of Human Papillomavirus (HPV) infections and their clinical impact. We aimed to characterize the vaginal microbiome in samples from 807 high‐risk HPVs (Hr‐HPV) positive women with a mean age of 41.45 ± 10.79 years who participated in the Regional Cervical Cancer Screening Program from the Northern Region of Portugal. Microbiome analysis was performed with commercial kits for the detection of 21 microorganisms. The most frequent microorganisms were Ureaplasma parvum (52.5%), Gardnerella vaginalis (GV) (34.5%), Atopobium vaginae (AV) (32.6%), Lacto (30.7%), and Mycoplasma hominis (MH) (23.5%). The distribution according to age reveals that MH, Mega1, GV, BVab2, AV, and Mob were more prevalent in women older than 41 years of age (p < 0.050), while Lacto is significantly decreased in this group (23.5% vs. 39.4%, p < 0.001; RR = 0.47). The risk analysis showed that Hr‐HPV‐16/‐18 and Hr‐HPV‐9val genotypes are associated with an increased risk of developing cervical abnormalities, while Lacto (p < 0.001; odd ratio [OR] = 0.33), GV (p = 0.0111; OR = 0.41), AV (p = 0.033; OR = 0.53) and Mob (p = 0.022; OR = 0.29) are associated with protection. Similar results were found for the risk of development atypical squamous cells cannot exclude HSIL/high‐grade squamous intraepithelial lesion. Overall, the multivariate analysis confirmed that lactobacillus and bacteria associated with bacterial vaginosis (GV, AV, and Mob) are associated with protection against the development of cervical abnormalities. This study provides important data to be included in the future management of risk stratification for Hr‐HPV‐positive women.
Vaccination status for mild and asymptomatic infections with SARS‐CoV‐2 Omicron BA.2 variant in Shanghai
Authors: Yin Yong , Lin Jilei , Yuan Shuhua , Tong Shilu , He Yi , Dong Bin , Zhang Fen , Chen Erzhen , Zheng Junhua , Wang Wei 
Published: May 2023

AbstractThis study aimed to evaluate the effects of different vaccine regimens on mild and asymptomatic infections with SARS‐CoV‐2 Omicron BA.2 variant in Shanghai. All asymptomatic patients and those with mild symptoms of Omicron infections were recruited from three major Fangcang shelter hospitals between March 26, 2022 and May 20, 2022. Nucleic acid for SARS‐CoV‐2 by real‐time reverse‐transcription polymerase chain reaction methods in nasopharyngeal swabs was assessed every day during the hospitalization. The value of cycle threshold lower than 35 was considered as positive result of SARS‐CoV‐2. A total of 214 592 cases were included in this study. The proportion of the asymptomatic patients was 76.90% and 23.10% of the recruited patients had mild symptoms. The median (interquartile range [IQR]: 25–75) duration of viral shedding (DVS) was 7 (5–10) days among all participants. The DVS varied greatly among different age groups. Children and the elderly had longer DVS compared with the adults. The booster shot of inactivated vaccine contributed to the shorter DVS in patients aged ≥70 years compared with the unvaccinated patients (8 [6–11] vs. 9 [6–12] days, p = 0.002]. Full inactivated vaccine regimen contributed to the shorter DVS in patients aged 3–6 years (7 [5–9] vs. 8 [5–10] days, p = 0.001]. In conclusion, the full inactivated vaccine regimen on children aged 3–6 years and booster inactivated vaccine regimen on the elderly aged ≥70 years appeared to be effective in reducing DVS. The booster vaccine regimen should be rigorously promoted and implemented.
Effects of the ABC pathway on clinical outcomes in a secondary prevention population of Chinese patients with atrial fibrillation: A report from the Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) registry
Authors: Fawzy Ameenathul M. , Kotalczyk Agnieszka , Guo Yutao , Wang Yutang , Lip Gregory Y. H. ,   the ChiOTEAF Registry Investigators
Published: May 2023

AbstractBackgroundThe atrial fibrillation better care (ABC) pathway is a simple, comprehensive framework that facilitates provision of integrated care for atrial fibrillation (AF) patients.ObjectiveWe evaluated management of AF patients in a secondary prevention cohort using the ABC pathway and examined the impact of ABC adherence on clinical outcomes.MethodsThe Chinese Patients with Atrial Fibrillation registry is a prospective registry conducted in 44 sites across China between October 2014 and December 2018. The primary outcome was the composite of all‐cause mortality/any thromboembolism (TE), all‐cause death, any TE and major bleeding at 1 year.ResultsOf the 6420 patients, 1588 (24.7%) had a prior stroke or transient ischemic attack and were identified as the secondary prevention cohort. After excluding 793 patients due to insufficient data, 358 (22.5%) were ABC compliant and 437 (27.5%) ABC noncompliant. ABC adherence was associated with a significantly lower risk of the composite outcome of all‐cause death/TE, odds ratio (OR) 0.28 (95% confidence interval [CI]: 0.11–0.71) and all‐cause death, OR 0.29 (95% CI: 0.09–0.90). Significant differences were not observed for TE, OR 0.27 (95% CI: 0.06–1.27) and major bleeding, OR 2.09 (95% CI: 0.55–7.97). Age and prior major bleeding were significant predictors of ABC noncompliance. Health‐related quality of life (QOL) was higher in the ABC compliant group versus the noncompliant group (EQ score 0.83 ± 0.17 vs. 0.78 ± 0.20; p = .004).ConclusionABC pathway adherence in secondary prevention AF patients was associated with a significantly lower risk of the composite outcome of all‐cause death/TE and all‐cause death, as well as better health‐related QOL.
sCTX II is a better biomarker than sMMP‐3 to identify early knee osteoarthritis
Authors: Singh Sudhir , Jindal Divyam , Khanna Rajat 
Published: May 2023

AbstractThe aim of this study is to assess the ability of serum MMP‐3 and serum CTX‐II levels to differentiate between normal and early knee osteoarthritis case (eKOA). Subjects with clinical features of primary knee osteoarthritis of K‐L Grade I and K‐L Grade II with ages more than 45 years were included in the case group (98), and healthy adults with ages less than 40 years were included in the control group (80). Those having knee pain for the last 3 months but having no radiological features were labeled as K‐L grade I and those having minimal osteophytes on radiographs were labeled as K‐L Grade II. Antero‐posterior views of knee and serum levels of MMP‐3 and CTX II were estimated. Cases show significantly higher values of both biomarkers than in controls (p < 0.0001). Both biomarkers show significantly higher values with an increase in K‐L Grades, that is, K‐L Grade 0 versus I (MMP‐3: p = 0.003; CTX‐II: p = 0.002), K‐L Grade I versus II (MMP‐3: p < 0.000; CTX‐II: p < 0.000). Multivariate analysis shows the dependence of both biomarkers only on K‐L Grades. ROC analysis suggests cutoff value between KL Grade 0 and Grade I (MMP‐3: 12.25 ng/mL; CTX II: 407.50 pg/mL) and between K L Grade I and Grade II (MMP‐3: 18.37 ng/mL; CTX II: 528.00 pg/mL). The discriminating ability of CTX II is superior between normal population and eKOA (CTX II: Accuracy: 66.83%, p = 0.0002; MMP‐3: Accuracy: 50.39%, p = 0.138), but MMP‐3 is superior than CTX II between eKOA and mild KOA (CTX II:67.52%, p < 0.000; MMP‐3: 70.69%, p < 0.000).
A novel algorithm to efficiently calculate the impingement‐free range of motion of irregularly‐shaped total hip arthroplasty components
Authors: Feng Tao , Tang Hao , Zhang Xiaogang , Zhang Yali , Zhou Yixin , Jin Zhongmin 
Published: May 2023

AbstractThere is great difficulty in quickly calculating the impingement‐free range of motion (IFROM) of hip components with complex shapes after total hip arthroplasty. We have established a new algorithm to investigate the effect of different shapes of hip components on the IFROM and impingement‐free safe zone (IFSZ). Then find the best combination of hip prosthesis and the optimal mounting position of the elevated‐rim liner under different radiographic anteversion (RA) and radiographic inclination (RI) of the cup. We found the larger the opening angle of the beveled‐rim liner and the smaller the cross‐sectional area of the stem neck with an inverted teardrop cross‐sectional shape, the greater the IFROM of the hip component. The beveled‐rim liner in combination with the stem neck with an inverted teardrop‐shaped cross‐section could provide the greatest IFSZ (excluding the flat‐rim liner). The optimal orientation of the elevated‐rim liner was the posterior‐inferior side (RI ≤ 37°), posterior‐superior side (RI ≥ 45°), and posterior side (37° ≤ RI ≤ 45°). Our novel algorithm provides a solution to analyze the IFROM of any hip prosthesis with any complex shape. The shape and size of the cross‐section of the stem neck, the orientation of the elevated rim, and the shape and opening angle of the liner are all critical factors for the quantitative calculation of the IFROM and mounting safe zone of the prosthesis. Stem necks with inverted teardrop cross‐section and beveled‐rim liner improved the IFSZ. The optimal direction of the elevated rim is not constant but varies with RI and RA.
Electrically stimulated eccentric contraction training enhances muscle mass, function, and size following volumetric muscle loss
Authors: Ziemkiewicz Natalia , Au Jeffrey , Chauvin Hannah M. , Garg Koyal 
Published: May 2023

AbstractVolumetric muscle loss (VML) overwhelms muscle's innate capacity for repair and can lead to permanent disability. The standard of care for VML injuries includes physical therapy, which can improve muscle function. The objective of this study was to develop and evaluate a rehabilitative therapy using electrically stimulated eccentric contraction training (EST) and determine the structural, biomolecular, and functional response of the VML‐injured muscle. This study implemented EST using three different frequencies (50, 100, and 150 Hz) in VML‐injured rats starting at 2 weeks postinjury. Four weeks of EST at 150 Hz showed a progressive increase in eccentric torque with an improvement in muscle mass (~39%), myofiber cross‐sectional area, and peak isometric torque (~37.5%) relative to the untrained VML‐injured sham group. EST at 150 Hz group also increased the number of large type 2B fibers (>5000 µm2). Elevated gene expression of markers associated with angiogenesis, myogenesis, neurogenesis, and an anti‐inflammatory response was also observed. These results suggest that VML‐injured muscles can respond and adapt to eccentric loading. The results of this study may aid in developing physical therapy regimens for traumatized muscles.
Patients with type 2 diabetes and severe periodontitis harbor a less pathogenic subgingival biofilm than normoglycemic individuals with severe periodontitis
Authors: Duarte Poliana M. , Felix Edcarlos , Santos Vanessa R. , Figueiredo Luciene C. , da Silva Hélio D. P. , Mendes Juliana A. V. , Feres Magda , Miranda Tamires S. 
Published: May 2023

AbstractBackgroundWhether, and to what extent, diabetes mellitus (DM) can affect the subgingival biofilm composition remains controversial. Thus, the aim of this study was to compare the composition of the subgingival microbiota of non‐diabetic and type 2 diabetic patients with periodontitis using 40 “biomarker bacterial species.”MethodsBiofilm samples of shallow (probing depth [PD] and clinical attachment level [CAL] ≤3 mm without bleeding) and deep sites (PD and CAL ≥5 mm with bleeding) of patients with or without type 2 DM were evaluated for levels/proportions of 40 bacterial species by checkerboard DNA‐DNA hybridization.ResultsA total of 828 subgingival biofilm samples from 207 patients with periodontitis (118 normoglycemic and 89 with type 2 DM) were analyzed. The levels of most of the bacterial species evaluated were reduced in the diabetic compared with the normoglycemic group, both in shallow and in deep sites. The shallow and deep sites of patients with type 2 DM presented higher proportions of Actinomyces species, purple and green complexes, and lower proportions of red complex pathogens than those of normoglycemic patients (P < 0.05).ConclusionsPatients with type 2 DM have a less dysbiotic subgingival microbial profile than normoglycemic patients, including lower levels/proportions of pathogens and higher levels/proportions of host‐compatible species. Thus, type 2 diabetic patients seem to require less remarkable changes in biofilm composition than non‐diabetic patients to develop the same pattern of periodontitis.
Material Design Concepts and Gas Separation Mechanism of CO2Selective Polyether‐Based Multiblock Copolymers
Authors: Rahman Md. Mushfequr 
Published: May 2023

AbstractAliphatic polyethers have been widely explored as membrane materials for the separation of CO2from other gases, e.g., N2, H2, CH4,O2etc. The polymeric membranes having aliphatic polyether segments, especially poly(ethylene oxide) segments, allow faster permeation of CO2compared to the light gases due to the affinity of the polar ether oxygen and quadrupolar CO2. Rational macromolecular design is the key to control the permeation of gases through these membrane materials. In this regard, multiblock copolymers having short amorphous polyether segments have been extensively investigated. A large number of tailor made polymers have been reported to get the best combination of permeability and selectivity. Material design concepts and structure–property relationships of these membrane materials in terms of CO2separation performance are thoroughly discussed in this review.
Antiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseases
Authors: Beura Samir K. , Dhapola Rishika , Panigrahi Abhishek R. , Yadav Pooja , Kumar Reetesh , Reddy Dibbanti H. , Singh Sunil K. 
Published: May 2023

AbstractThe blood platelet plays an important role but often remains under‐recognized in several vascular complications and associated diseases. Surprisingly, platelet hyperactivity and hyperaggregability have often been considered the critical risk factors for developing vascular dysfunctions in several neurodegenerative diseases (NDDs) like Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis. In addition, platelet structural and functional impairments promote prothrombotic and proinflammatory environment that can aggravate the progression of several NDDs. These findings provide the rationale for using antiplatelet agents not only to prevent morbidity but also to reduce mortality caused by NDDs. Therefore, we thoroughly review the evidence supporting the potential pleiotropic effects of several novel classes of synthetic antiplatelet drugs, that is, cyclooxygenase inhibitors, adenosine diphosphate receptor antagonists, protease‐activated receptor blockers, and glycoprotein IIb/IIIa receptor inhibitors in NDDs. Apart from this, the review also emphasizes the recent developments of selected natural antiplatelet phytochemicals belonging to key classes of plant‐based bioactive compounds, including polyphenols, alkaloids, terpenoids, and flavonoids as potential therapeutic candidates in NDDs. We believe that the broad analysis of contemporary strategies and specific approaches for plausible therapeutic treatment for NDDs presented in this review could be helpful for further successful research in this area.