bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of endothelial gene polymorphisms in Spanish patients with vascular dementia and Alzheimer´s disease
Authors: Manso-Calderón Raquel , Cacabelos-Pérez Purificación , Sevillano-García M. Dolores , Herrero-Prieto M. Elisa , González-Sarmiento Rogelio 
Published: August 2023

AbstractThere is increasing evidence for the involvement of blood–brain barrier (BBB) in vascular dementia (VaD) and Alzheimer´s disease (AD) pathogenesis. However, the role of endothelial function-related genes in these disorders remains unclear. We evaluated the association of four single-nucleotide polymorphisms (VEGF, VEGFR2 and NOS3) with diagnosis and rate of cognitive decline in AD and VaD in a Spanish case–control cohort (150 VaD, 147 AD and 150 controls). Participants carrying -604AA genotype in VEGFR2 (rs2071559) were less susceptible to VaD after multiple testing. Further analysis for VaD subtype revealed a significant difference between small-vessel VaD patients and controls, but not for large-vessel VaD patients. In addition, -2578A and -460C alleles in VEGF (rs699947 and rs833061) showed to decrease the risk of AD, whereas NOS3 (rs1799983) influenced disease progression. Our study supports previous findings of a deleterious effect of VEGFR2 reduced expression on small-vessel disease, but not on large-vessel disease; as well as a detrimental effect of down-regulating VEGF and eNOS in AD, affecting vascular permeability and neuronal survival. These data highlight the relevance of endothelial function and, therefore, BBB in both VaD and AD.
Multi-omics analyses based on genes associated with oxidative stress and phospholipid metabolism revealed the intrinsic molecular characteristics of pancreatic cancer
Authors: Wang Hongdong , Guo Hui , Sun Jiaao , Wang Yuefeng 
Published: August 2023

AbstractOxidative stress (OS), which impacts lipid metabolic reprogramming, can affect the biological activities of cancer cells. How oxidative stress and phospholipid metabolism (OSPM) influence the prognosis of pancreatic cancer (PC) needs to be elucidated. The metabolic data of 35 pancreatic tumor samples, 34 para-carcinoma samples, and 31 normal pancreatic tissues were obtained from the previously published literature. Pan-cancer samples were obtained from The Cancer Genome Atlas (TCGA). And the Gene Expression Omnibus (GEO), International Cancer Genome Consortium (ICGC), ArrayExpress, and the Genotype-Tissue Expression (GTEx) databases were searched for more PC and normal pancreatic samples. The metabolites in PC were compared with normal and para-carcinoma tissues. The characteristics of the key OSPM genes were summarized in pan-cancer. The random survival forest analysis and multivariate Cox regression analysis were utilized to construct an OSPM-related signature. Based on this signature, PC samples were divided into high- and low-risk subgroups. The dysregulations of the tumor immune microenvironment were further investigated. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was conducted to investigate the expression of genes in the signature in PC and normal tissues. The protein levels of these genes were further demonstrated. In PC, metabolomic studies revealed the alteration of PM, while transcriptomic studies showed different expressions of OSPM-related genes. Then 930 PC samples were divided into three subtypes with different prognoses, and an OSPM-related signature including eight OSPM-related genes (i.e., SLC2A1, MMP14, TOP2A, MBOAT2, ANLN, ECT2, SLC22A3, and FGD6) was developed. High- and low-risk subgroups divided by the signature showed different prognoses, expression levels of immune checkpoint genes, immune cell infiltration, and tumor microenvironment. The risk score was negatively correlated with the proportion of TIL, pDC, Mast cell, and T cell co-stimulation. The expression levels of genes in the signature were verified in PC and normal samples. The protein levels of SLC2A1, MMP14, TOP2A, MBOAT2, ANLN, and SLC22A3 showed up-regulation in PC samples compared with normal tissues. After integrating metabolomics and transcriptomics data, the alterations in OSPM in PC were investigated, and an OSPM-related signature was developed, which was helpful for the prognostic assessment and individualized treatment for PC.
Exact solution of the 1D Dirac equation for a pseudoscalar interaction potential with the inverse-square-root variation law
Authors: Ishkhanyan A. M. , Krainov V. P. 
Published: August 2023

AbstractWe present the exact solution of the one-dimensional stationary Dirac equation for the pseudoscalar interaction potential, which consists of a constant and a term that varies in accordance with the inverse-square-root law. The general solution of the problem is written in terms of irreducible linear combinations of two Kummer confluent hypergeometric functions and two Hermite functions with non-integer indices. Depending on the value of the indicated constant, the effective potential for the Schrödinger-type equation to which the problem is reduced can form a barrier or well. This well can support an infinite number of bound states. We derive the exact equation for the energy spectrum and construct a rather accurate approximation for the energies of bound states. The Maslov index involved turns out to be non-trivial; it depends on the parameters of the potential.
Big data evidence of the impact of COVID-19 hospitalizations on mortality rates of non-COVID-19 critically ill patients
Authors: Wichmann Bruno , Moreira Wichmann Roberta 
Published: August 2023

AbstractThe COVID-19 virus caused a global pandemic leading to a swift policy response. While this response was designed to prevent the spread of the virus and support those with COVID-19, there is growing evidence regarding measurable impacts on non-COVID-19 patients. The paper uses a large dataset from administrative records of the Brazilian public health system (SUS) to estimate pandemic spillover effects in critically ill health care delivery, i.e. the additional mortality risk that COVID-19 ICU hospitalizations generate on non-COVID-19 patients receiving intensive care. The data contain the universe of ICU hospitalizations in SUS from February 26, 2020 to December 31, 2021. Spillover estimates are obtained from high-dimensional fixed effects regression models that control for a number of unobservable confounders. Our findings indicate that, on average, the pandemic increased the mortality risk of non-COVID-19 ICU patients by 1.296 percentage points, 95% CI 1.145–1.448. The spillover mortality risk is larger for non-COVID patients receiving intensive care due to diseases of the respiratory system, diseases of the skin and subcutaneous tissue, and infectious and parasitic diseases. As of July 2023, the WHO reports more than 6.9 million global deaths due to COVID-19 infection. However, our estimates of spillover effects suggest that the pandemic’s total death toll is much higher.
3D mouse pose from single-view video and a new dataset
Authors: Hu Bo , Seybold Bryan , Yang Shan , Sud Avneesh , Liu Yi , Barron Karla , Cha Paulyn , Cosino Marcelo , Karlsson Ellie , Kite Janessa , Kolumam Ganesh , Preciado Joseph , Zavala-Solorio José , Zhang Chunlian , Zhang Xiaomeng , Voorbach Martin , Tovcimak Ann E. , Ruby J. Graham , Ross David A. 
Published: August 2023

AbstractWe present a method to infer the 3D pose of mice, including the limbs and feet, from monocular videos. Many human clinical conditions and their corresponding animal models result in abnormal motion, and accurately measuring 3D motion at scale offers insights into health. The 3D poses improve classification of health-related attributes over 2D representations. The inferred poses are accurate enough to estimate stride length even when the feet are mostly occluded. This method could be applied as part of a continuous monitoring system to non-invasively measure animal health, as demonstrated by its use in successfully classifying animals based on age and genotype. We introduce the Mouse Pose Analysis Dataset, the first large scale video dataset of lab mice in their home cage with ground truth keypoint and behavior labels. The dataset also contains high resolution mouse CT scans, which we use to build the shape models for 3D pose reconstruction.
Ocean-wide comparisons of mesopelagic planktonic community structures
Authors: Rigonato Janaina , Budinich Marko , Murillo Alejandro A , Brandão Manoela C , Pierella Karlusich Juan J , Soviadan Yawouvi Dodji , Gregory Ann C , Endo Hisashi , Kokoszka Florian , Vik Dean , Henry Nicolas , Frémont Paul , Labadie Karine , Zayed Ahmed A , Dimier Céline , Picheral Marc , Searson Sarah , Poulain Julie , Kandels Stefanie , Pesant Stéphane , Karsenti Eric ,   Tara Oceans coordinators, Acinas Silvia G , Boss Emmanuel , Cochrane Guy , de Vargas Colomban , Gorsky Gabriel , Grimsley Nigel , Guidi Lionel , Hingamp Pascal , Karp-Boss Lee , Not Fabrice , Raes Jeroen , Sardet Christian , Speich Sabrina , Bork Peer , Bowler Chris , de Vargas Colomban , Eveillard Damien , Gehlen Marion , Iudicone Daniele , Lombard Fabien , Ogata Hiroyuki , Stemmann Lars , Sullivan Matthew B , Sunagawa Shinichi , Wincker Patrick , Chaffron Samuel , Jaillon Olivier 
Published: August 2023

Abstract
For decades, marine plankton have been investigated for their capacity to modulate biogeochemical cycles and provide fishery resources. Between the sunlit (epipelagic) layer and the deep dark waters, lies a vast and heterogeneous part of the ocean: the mesopelagic zone. How plankton composition is shaped by environment has been well-explored in the epipelagic but much less in the mesopelagic ocean. Here, we conducted comparative analyses of trans-kingdom community assemblages thriving in the mesopelagic oxygen minimum zone (OMZ), mesopelagic oxic, and their epipelagic counterparts. We identified nine distinct types of intermediate water masses that correlate with variation in mesopelagic community composition. Furthermore, oxygen, NO3− and particle flux together appeared as the main drivers governing these communities. Novel taxonomic signatures emerged from OMZ while a global co-occurrence network analysis showed that about 70% of the abundance of mesopelagic plankton groups is organized into three community modules. One module gathers prokaryotes, pico-eukaryotes and Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) from oxic regions, and the two other modules are enriched in OMZ prokaryotes and OMZ pico-eukaryotes, respectively. We hypothesize that OMZ conditions led to a diversification of ecological niches, and thus communities, due to selective pressure from limited resources. Our study further clarifies the interplay between environmental factors in the mesopelagic oxic and OMZ, and the compositional features of communities.
A comparative study reveals the relative importance of prokaryotic and eukaryotic proton pump rhodopsins in a subtropical marginal sea
Authors: Ma Minglei , Li Hongfei , Wang Cong , Li Tangcheng , Wang Jierui , Yuan Huatao , Yu Liying , Wang Jingtian , Li Ling , Lin Senjie 
Published: August 2023

Abstract
Proton-pump rhodopsin (PPR) in marine microbes can convert solar energy to bioavailable chemical energy. Whereas bacterial PPR has been extensively studied, counterparts in microeukaryotes are less explored, and the relative importance of the two groups is poorly understood. Here, we sequenced whole-assemblage metatranscriptomes and investigated the diversity and expression dynamics of PPR in microbial eukaryotes and prokaryotes at a continental shelf and a slope site in the northern South China Sea. Data showed the whole PPRs transcript pool was dominated by Proteorhodopsins and Xanthorhodopsins, followed by Bacteriorhodopsin-like proteins, dominantly contributed by prokaryotes both in the number and expression levels of PPR unigenes, although at the continental slope station, microeukaryotes and prokaryotes contributed similarly in transcript abundance. Furthermore, eukaryotic PPRs are mainly contributed by dinoflagellates and showed significant correlation with nutrient concentrations. Green light-absorbing PPRs were mainly distributed in &gt;3 μm organisms (including microeukaryotes and their associated bacteria), especially at surface layer at the shelf station, whereas blue light-absorbing PPRs dominated the &lt;3 μm (mainly bacterial) communities at both study sites, especially at deeper layers at the slope station. Our study portrays a comparative PPR genotype and expression landscape for prokaryotes and eukaryotes in a subtropical marginal sea, suggesting PPR’s role in niche differentiation and adaptation among marine microbes.
Multiscale and multidirection depth map super resolution with semantic inference
Authors: Xu Dan , Fan Xiaopeng , Zhao Debin , Gao Wen 
Published: August 2023

AbstractDepth map super resolution has been paid much attention in 3D applications due to the limitation of depth sensors. Few textures in objects with clear contours along them is the most important characteristic of depth map. An efficient image representation should be directional, multiscale and anisotropic. From this we propose a novel multiscale and multidirection depth map super resolution framework with semantic inference to improve the quality of depth maps. In this framework, a multiscale and multidirection depth map contour fusion scheme captures and assembles intrinsic geometrical structures through a multiview non‐subsampled contourlet transform manner. This scheme not only isolates the discontinuities of contours but retains the smoothness along the contours. The semantic inference is also utilized to segment and label the depth map into objects/backgrounds‐level which are coplanar. Furthermore, a semantic‐aware label refinement strategy is introduced to correct the rarely inaccurate labels of the label map for upscaling the target pixel with pixels in the same object or background. Experimental results on benchmark depth map dataset demonstrate that the proposed multiscale and multidirection depth map super resolution framework with semantic inference has a significant improvement than the state‐of‐the‐art algorithms both visually and quantitatively.
IoT-Enabled Smart Parking: Enhancing Efficiency and Sustainability in Smart Cities
Authors: Ouhammou Imrane , Chafiq Tarik , Hmamou Mohamed 
Published: August 2023

The field of smart parking is growing rapidly and has many potential applications in densely populated urban areas. Internet of Things (IoT) and Arduino-based smart parking systems offer an innovative solution to solve parking problems in real time. Among other things, these systems reduce traffic congestion, improve road safety, reduce greenhouse gas emissions, and improve user experience.
In this paper, we present a smart parking system that uses an innovative architecture and algorithm to optimize vehicle parking. The system also tracks cars, their location, entry and exit details, and account management. An infrared sensor is integrated into the system to monitor the entry and exit of vehicles. This sensor uses beams of light to detect the presence of vehicles in a specific parking area, allowing for efficient use of available parking space.
This project has many benefits, such as optimized space utilization, reduced congestion and pollution, and an improved user experience. The system can be deployed in a variety of environments, including underground parking garages, shopping malls, airports, and train stations.
Arteriovenous Malformation of Pelvis Treated with Hypothermic Arrest and Hemipelvectomy
Authors: Raithel Steven C. , Vieth Donna G. , Keltner Raymond M. , Willman Vallee L. 
Published: August 2023

Arteriovenous malformations are lesions which may cause significant complications including congestive heart failure, venous insufficiency, limb ischemia, or difficulty with feeding and respiration. The treatment of arteriovenous malformations can be quite involved due to the complexity of the lesion.
The use of cardiopulmonary bypass equipment in noncardiac cases is not new as is evident in equipment use in liver transplantation, neurosurgery, and the delivery of hyperthermic anticancer therapy.
The authors report on a 30-year-old male with a large arteriovenous malformation involving the left thigh and pelvis treated with deep hypothermic cardiopulmonary arrest and hemipelvectomy.
The Volume Allowance Formula as a Guide to Non-Haemic Solution Administration
Authors: Vinas Michael S. 
Published: August 2023

We have developed a formula sequence which calculates the predicted blood volume, hemodilutional hematocrit and conjectively figures the amount of non-haemic solution margin allowable before reaching a minimally acceptable or ‘target’ hematocrit in the adult patient.
Another application of the formula calculates the value for the amount of prime reduction to prevent the addition of blood to the ECC priming volume. The formula also provides the figures for the amount of blood to add to the prime of the extracorporeal circuit in order to maintain a target hematocrit.
The Course of D-Dimers as Fibrinolytic Products Generated During Cardiopulmonary Bypass
Authors: Moretz Tim L. , Riley Jeff B. , Jeter Elaine K. , Sutton Robin G. , Bishop David G. , Kratz John M. , Crawford Fred A. 
Published: August 2023

D-Dimers are the expressed degradation products of the lysis of fibrin. Fibrin monomers may normally occur during routine cardiopulmonary bypass (CPB); therefore, fibrinolysis could play a protective role. Serum D-dimer levels were observed at six events associated with routine CPB. An expected patient D-dimer level while heparinized would be <0.5 mcg/ml showing that fibrin is not being formed.
The majority of elevated D-dimer levels came at the termination of CPB when only one of twenty patients investigated showed a minimal D-dimer level of <0.5. The other patients ranged from 0.5 to >8.0 ug/ml at termination of CPB.

Table A

Event samples with respective ACT and D-Dimer

Event
ACT
DD Level

Baseline
123 ± 15
1.0 ± 1.1

Post Sternotomy

1.6 ± 1.9

5 min. on CPB
497 ± 84
1.6 ± 2.3

Terminate CPB
432 ± 84
5.1 ± 2.8

Post Protamine
116 ± 11
5.1 ± 2.8

1 Hr. Post Op

4.9 ± 3.0

ACT = mean activated clotting time ± 1SD

The last three event D-dimer levels were significantly greater than the D-dimer from the first three events (p<0.01) demonstrating that fibrinolysis may be a normal occurrence during CPB. The weak correlation in the rise in D-dimers during CPB versus the minimal CPB ACT data (n=20, r=.114) although not statistically significant, suggests that ACTs should be maintained above 480 seconds throughout CPB to minimize fibrin formation and therefore minimize fibrinolysis.
Perioperative Autotransfusion and its Correlation to Hemostasis and Coagulopathies
Authors: Page Paul 
Published: August 2023

The use of autologous blood techniques affords the reduction or elimination of homologous blood transfusions for most patients. In addition, for certain religious faiths such as Jehovah’s Witnesses or those patients with rare blood types, intraoperative salvage and retUrn of the patient’s own blood is the only source of available blood.
Autologous blood salvage in the perioperative period includes:
• Hemodilution
• Intraoperative salvage of lost blood
• Postoperative collection of shed blood
Perioperatively, autologous blood is salvaged and returned and the volumes involved do not create any hematological problems for the patient. In those cases involving large volumes of blood being processed and returned to the patient, the autotransfusionist must be aware of the possible alterations that may occur in the patient’s coagulation system. The collection and reinfusion of wound drainage fluids from operative sites has the potential to cause severe bleeding problems. This paper will present an overview of autologous blood salvage techniques in the perioperative period along with a review of the clinical effects of autotransfusion on hemostasis. Also discussed will be possible coagulopathies that can be caused by returning collected autologous blood.
Effects of Imidazole Buffered Cardioplegia on Isolated Guinea Pig Hearts
Authors: Jenkins Eric H. , Beckley Philip D. 
Published: August 2023

The imidazole moiety of histidine is responsible for the alpha-stat theory of intracellular pH regulation, which conserves the function of essential enzymes at different temperatures. This study tests the hypothesis that the addition of imidazole to cardioplegia enhances myocardial protection.
Eighteen isolated guinea pig hearts were randomly divided into 3 groups and perfused with Krebs-Henseleit solution at 35°C using the Langendorff technique. Perfusion was discontinued after 25 minutes, and each group was arrested by the infusion of cold (4-6°C) oxygenated cardioplegic solution at 2.8 mL/min/ g. Group 1 acted as a control, while Groups 2 and 3 were infused with a cardioplegic solution containing 15 mmol/L and 30 mmol/L imidazole respectively. After 30 minutes of hypothermic (< 16°C) ischemia, perfusion was resumed for 15 minutes. Hemodynamic measurements and analysis of perfusate and effluent were made prior to arrest and after 15 minutes of reperfusion. Post-ischemic lactate levels were linearly related to cardioplegia pH (r = 0.7148) and non-bicarbonate buffer capacity (r = 0.8006). Cardiac edema was lower in Group 3 (P < 0.05). Persistent arrhythmic activity was exhibited by 83% of Group 1 throughout reperfusion, compared to 33% and 14% of Groups 2 and 3 respectively. These results suggest that the addition of imidazole enhanced anaerobic metabolism during ischemia, facilitating the preservation of membrane integrity and function.
Cephalic Jugular Venous Blood Gas Measurement during Neonatal Venoarterial Extracorporeal Membrane Oxygenation
Authors: O'Connor Timothy A. , Haney Barbara M. , Shaffer Stanley G. , Crist Cary E. 
Published: August 2023

Cannulation of the cephalic portion of the right internal jugular vein during extracorporeal membrane oxygenation (ECMO) allows for increased venous return flow to the circuit.
This procedure also allows access to venous drainage from the brain. We reviewed data from simultaneous blood gases obtained from the cephalic jugular vein and the mixed venous return in 5 neonates during venoarterial ECMO. Cephalic venous pO2 values were significantly lower than mixed venous pO2 values (P < .001). The values for pH and pCO2 did not vary between the sites. Our experience with 34 infants using cephalic jugular drainage is reviewed. Since the institution of right jugular venous drainage, the intracranial hemorrhage rate in neonates undergoing ECMO at our center has decreased from 34% to 6% (p < .01).
Review of Deep Hypothermia and Circulatory Arrest Techniques For Surgical Repair of Giant Cerebral Aneurysms
Authors: Mongero Linda B. , Sistino Joseph J. 
Published: August 2023

Early experience in the 1960s with the repair of giant cerebral aneurysms utilizing cardiopulmonary bypass (CPB) with deep hypothermia and circulatory arrest was reviewed. However, due to the complications associated with CPB, its use was abandoned in the early 1970's. Surface cooling alone with open chest cardiac massage was then employed successfully in a series of neurosurgical patients.
Reintroduction of bypass techniques for core cooling using peripheral cannulation combined with neurosurgical advances has decreased the morbidity associated with this technique in the 1980s. However, some centers continue to perform these procedures with open chest cardiopulmonary bypass. Although there are advantages to the open chest technique, it is no longer necessary in most patients. With a long thin-walled venous cannula advanced from the femoral vein to the right atrium, combined with a centrifugal pump in the venous line, adequate venous return and cardiac decompression can be achieved without the need for a sternotomy. Advances in perfusion techniques and anesthetic monitoring are the hallmarks of the successful outcome in neurosurgical repairs of giant cerebral aneurysms in the 1990s.