bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting circFOXO3 to Modulate Integrin β6 Expression in Periodontitis: A Potential Therapeutic Approach
Authors: Xu Mingyan , Zhu Feixiang , Guo Yifan , Liu Fan , Shi Songlin , Yang Ling , Huang Rui , Deng Xiaoling 
Published: January 2025

ABSTRACTAimsCircular RNA forkhead box O3 (circFOXO3) is crucial in regulating inflammation in lung and heart injuries. However, its role in periodontitis remains unclear. We sought to elucidate the effects of circFOXO3 on periodontitis progression and related molecular mechanisms.MethodsReverse‐transcription quantitative polymerase chain reaction and fluorescence in situ hybridization were used to quantify and localize circFOXO3 expression. The mechanism by which circFOXO3 promotes inflammation in periodontitis was investigated using epithelial cells, human gingival epithelium and a rat model of ligature‐induced periodontitis.ResultscircFOXO3 expression was abnormally high in the gingival epithelial tissues of patients with periodontitis. Elevated circFOXO3 levels down‐regulated microRNA (miR)‐141‐3p, leading to increased FOXO3 expression. FOXO3 interacted with JunB to form a transcriptional‐repression complex that inhibited the integrin β6 (ITGβ6)‐mediated activation of transforming growth factor β (TGF‐β) in epithelial cells. Through the miR‐141‐3p/FOXO3/JunB axis, circFOXO3 suppressed TGF‐β signalling, thereby exacerbating periodontal inflammation. Finally, circFOXO3 inhibition hindered disease progression and restored TGF‐β activity in vivo via the FOXO3/JunB/ITGβ6 pathway.ConclusionOur study identified a novel mechanism by which circFOXO3 contributes to periodontal inflammation through a complex transcriptional regulatory network involving miR‐141‐3p, FOXO3, JunB and ITGβ6. These findings highlight potential therapeutic targets for the development of effective treatments for this debilitating disease.
Distal Access Catheter Improves Balloon Guide and Stent Retriever Thrombectomy Outcomes in Nonagenarians
Authors: Puig Josep , Werner Mariano , Dolz Guillem , Pascagaza Alejandro , Daunis‐i‐Estadella Pepus , Comas‐Cufí Marc , González Eva , Fondevila Jon , Vega Pedro , Murias Eduardo , Romero Veredas , Martínez Carlos , Aparici‐Robles Fernando , Morales‐Caba Lluis , Remollo Sebastià , Rodríguez‐Caamaño Isabel , Pérez‐García Carlos , Rosati Santiago , Bashir Saima , Vielba‐Gomez Isabel , Aixut Sonia , Paipa Andrés Julian , Martínez‐Fernández Javier , Aguilar Yeray , Fandiño Eduardo , Barbieri Giorgio , García‐Villalba Blanca , Cuba Víctor , Castaño Miguel , Blasco Jordi ,   ROSSETTI Group
Published: January 2025

ABSTRACTBackground and PurposeThe safety and effectiveness of endovascular techniques in elderly patients with large vessel occlusion (LVO) remain controversial. We investigated the angiographic and clinical outcomes of nonagenarians treated with different endovascular techniques using a balloon guide catheter (BGC), distal aspiration catheter (DAC), and/or stent retriever (SR).MethodsWe analyzed the data from the Registry of Combined versus Single Thrombectomy Techniques (ROSSETTI) of consecutive nonagenarian patients with anterior circulation LVO and compared the outcomes of those treated with BGC+noDAC+SR (101‐group), BGC+DAC+SR (111‐group), and noBGC+DAC+SR (011‐group). Demographic, clinical, angiographic, and clinical outcome data (National Institute of Health Stroke Scale score at 24 h [24h‐NIHSS] and modified Rankin Scale score at 3 months) were compared. Predictors of the first‐pass effect (FPE), defining Modified Treatment In Cerebral Ischemia 2c‐3 (mTICI 2c‐3) after one pass, were explored.ResultsOf the 4111 patients from the ROSSETTI registry, 243 nonagenarians (68.7% female) were included in the analysis. The distribution of endovascular techniques was 101‐group (61.4%), 111‐group (15.6%), and 011‐group (23%). The 101‐group and 111‐group had significantly shorter procedural times than the 011‐group. The 111‐group had a higher FPE rate, a lower number of passes, and a higher rate of final mTICI ≥2c than the other groups. The 24h‐NIHSS score was significantly lower in the 111‐group. In multivariate analysis, the only independent predictor for FPE was the BGC+DAC+SR endovascular technique (odds ratio 2.74 [confidence interval 1.16–6.47]; p = 0.021).ConclusionsThe addition of a DAC to a BGC increases the likelihood of FPE in nonagenarians with anterior circulation LVO SR‐based thrombectomy for acute stroke.
Comparison of removal of intestinal foreign bodies using orogastric retrieval techniques versus gastrotomies in dogs and cats
Authors: Prettegiani B. , Maritato K. 
Published: January 2025

ObjectivesThe objective of the study is to describe a surgical technique of intestinal foreign body retrieval without gastrotomy using an endoscopic grasper and digital manipulation, and to compare short‐term outcomes with patients who had similar obstructive intestinal foreign bodies removed via gastrotomy.Materials and MethodsMedical records of dogs and cats with intestinal foreign bodies that underwent treatment with either the orogastric retrieval technique or gastrotomy between November 2021 and July 2023 were extracted. A comparison of the short‐term outcomes was performed between the techniques.ResultsFifty cases were enrolled with all cases having material manipulated out of the obstructive location in the intestinal tract and removed either by gastrotomy or orogastric retrieval via digital manipulation of the material into an endoscopic grasper or orogastric tube. No statistical differences were appreciated in intra‐operative or post‐operative complication rate, time to first meal or time to discharge. The gastrotomy procedures took 11.98 minutes longer than the endoscopic retrieval group.Clinical SignificanceSurgical removal of foreign bodies through a laparotomy‐assisted orogastric retrieval technique is possible without the assistance of an endoscopy unit and offered no difference in complication rate or surgical outcomes.
Honour and humiliation: Emotional economies of war and defeat
Authors: Frevert Ute 
Published: January 2025

AbstractThe article looks at nationalism, war and defeat from a history of emotions perspective. It frames nationalism as a political programme and mindset that enlists emotions of belonging and solidarity, but also fear, anger, hatred and contempt. Investigating the role and experience of wars within nationalist emotional economies, the article mainly focuses on the power of national honour to integrate and involve people of all classes, races and genders. By drawing on honour's opposite, shame, it then analyses stories of defeat in terms of what they tell us about the construction and experience of humiliation. Timewise, the article covers the ‘age of nationalism’, that is the 19th and 20th centuries, with particular reference to the First World War. The case studies mostly concern Central and Western Europe, and chiefly France and Germany.
The Influence of Electroencephalographic Density Spectral Array Guidance of Sevoflurane Administration on Recovery From General Anesthesia in Children. A Randomized Controlled Trial
Authors: de Heer Iris J. , Raab Hannah A. C. , de Vries Joost , Karaöz‐Bulut Gulhan , Weber Frank 
Published: January 2025

ABSTRACTBackgroundIn children, monitoring depth of anesthesia is challenging because of the still developing brain. Electroencephalographic density spectral array monitoring provides age‐ and anesthetic drug‐specific electroencephalographic patterns, making it suitable for use in children. Yet, not much is known about the benefits of using density spectral array on post‐operative recovery in children.AimIn this randomized controlled trial, the primary aim was to investigate the influence of density spectral array monitoring during general anesthesia on the speed of recovery after surgery.MethodsChildren aged 6 months–12 years scheduled for elective surgery under general anesthesia supplemented with caudal analgesia had either sevoflurane anesthesia titrated to maintain a characteristic density spectral array pattern or based on a predefined end‐tidal sevoflurane concentration of 2.3% (standard care group). The time interval between the discontinuation of sevoflurane and the moment when discharge criteria from the operating room were met (Steward score of 3 or more) was defined as the primary outcome parameter of this trial.ResultsData from 96 children were analyzed. The time until discharge readiness from the operating room was shorter in group density spectral array (6 min. [13[4–16.8]]) than in group standard care (12 min. [18[6–24.3]]), with a difference between medians of 6 min (95% CI −7 to 0), p = 0.041. The mean end‐tidal sevoflurane concentration during the surgical procedure was lower in group density spectral array, 1.8% (0.34) versus 2.3% (0.1) in group standard care (95% CI 0.4–0.7), p < 0.001.ConclusionThis randomized controlled trial provides initial evidence of an added value of density spectral array monitoring in terms of the speed of recovery and allows sevoflurane to be dosed 22% lower during maintenance than with a more traditional approach using a minimal alveolar concentration of 0.9.Trial RegistrationClinicalTrials.gov identifier: NCT05525104
The mobilizing effects of California's Proposition 47 on high incarceration communities
Authors: Krishnamurthy Arvind 
Published: January 2025

AbstractExisting research provides conflicting accounts of whether indirect exposure to the American carceral state mobilizes geographically proximate community voters. One possible reason for these mixed findings may be a missing connection between electoral participation and expectations of change in criminal legal policies. To remedy this problem, I leverage the inclusion of a well‐publicized ballot initiative in California, Proposition 47. The 2014 measure would substantially reduce the incarcerated population in the state and lower sanctions for non‐violent criminal offenses. Using census tract‐level vote returns and incarceration rates, I show that increasing levels of tract incarceration are associated with an increase in turnout during the year of Proposition 47 (3.8 to 6.9 pp) relative to past turnout levels. In addition, I show that higher tract incarceration rates are associated with more support for the Proposition (6.9 pp. difference). These results suggest that carceral state exposure may affect community political engagement differently based on the direct policy relevance of a given election for changing carceral state functioning.
Who Takes the Cake? The Heterogeneous Effect of European Central Bank Accommodative Monetary Policy across Income Classes
Authors: Bárcena‐Martín Elena , Martín‐Fuentes Natalia , Pérez‐Moreno Salvador 
Published: January 2025

AbstractThis work provides evidence of the heterogeneous effects of the ECB's monetary policy across income classes. In particular, this investigation focuses on the labor market channel. Based on EU‐SILC data, we estimate country‐specific structural vector autoregressions (SVAR) models to analyze the impact of the expansionary monetary policy shocks over the 2006–2019 period. The results suggest that monetary easing helped decrease unemployment rates for lower‐ and middle‐income classes, to a larger extent for the former. This differential impact is accounted for a stronger improvement in job finding rates for classes located at the bottom of the income distribution. Conversely, the employment status of the upper class remained largely unaffected. The analysis identifies a positive impact of expansionary monetary policy on real labor income, which seems to have mostly benefitted the upper class. Overall, our results suggest that expansionary monetary policy helped decrease labor income inequality by exerting a stronger positive impact on lower‐income households.
Small‐ and large‐group instruction and a didactic method in mathematics for low‐performing adolescents: results from a randomized field experiment
Authors: Gunnes Trude , Kirkebøen Lars J. , Lindenskov Lena , Rønning Marte 
Published: January 2025

AbstractThere is an increasing focus on helping low‐performing adolescents in school. We have randomly exposed low‐performing adolescents in mathematics in grade 8 to variations in key school inputs: teacher training, teaching material, and group size. Test scores of students in small groups taught by newly trained teachers provided with teaching material increased by 0.06 standard deviation. We find no impact on students in large groups with trained teachers and no new teaching material. Classroom observations indicate higher implementation fidelity of the didactic method among teachers of small groups, suggesting that targeted instruction with suitable teaching material in small and homogeneous groups can improve results for low‐performing adolescents and reduce achievement gaps in lower secondary education.
Influence of Menstrual Phase and Symptoms on Sleep Before and After Matches for Professional Footballers
Authors: Brown Georgia A. , Fullagar Hugh H. K. , Duffield Rob 
Published: January 2025

ABSTRACTThis study investigated the association of menstrual cycle phase and symptoms with objective and subjective sleep measures from professional footballers before and after matches. Twenty‐three non‐hormonal contraceptive‐using professional footballers (from four clubs) were monitored for up to four menstrual cycles during a domestic league season. Menstrual phases (menstruation, mid‐late follicular, luteal) were determined using calendar counting and urinary hormone tests (luteinizing hormone and pregnandiol‐3‐glucuronide). Players rated the severity of 18 symptoms on the evenings of matches and the following two evenings. Individual daily summed menstrual symptom severity (MSS) scores were calculated. Subjective sleep quality was rated the morning of matches and the following two mornings. Objective sleep (bedtime, waketime, total sleep time [TST], sleep onset latency, wake after sleep onset, sleep efficiency) obtained from actigraphy was measured the night prior to (MN−1), of (MN), and following (MN+1) matches. Linear mixed models were performed for each sleep measure to examine the effects of menstrual phase and symptoms. Bedtime was significantly later for MN (p < 0.001), waketime was significantly earlier for MN+1 (p < 0.001), and TST was significantly longer for MN−1 (p < 0.001). Menstrual phase did not have a significant effect on any sleep variable (p > 0.05). Increased MSS score was associated with increased TST (p = 0.03) and increased waketime (p = 0.03). Increased lower back pain severity and mood changes/anxiety severity were associated with increased waketime (p = 0.048) and TST (p = 0.009), respectively. Overall, bedtime and waketime were affected by the night related to matches, with increased TST the night before a match. Menstrual phase was not related to any objective or subjective sleep variables, whilst increasing menstrual symptom severity was related to later waketime and longer TST.
Hydro Tasmania — King Island Case Study
Authors: Gamble Simon , Piekutowski Marian , Willems Ryan , Rao K. R. 
Published: January 2025

Hydro Tasmania has developed a remote island power system in the Bass Strait, Australia, that achieves a high level of renewable energy penetration through the integration of wind and solar generation with new and innovative storage and enabling technologies. The ongoing development of the power system is focused on reducing or replacing the use of diesel fuel while maintaining power quality and system security in a low inertia system. In recent years Hydro Tasmania has undertaken several renewable energy developments on King Island with the aim to reduce dependence on diesel, reduce operating cost and greenhouse gas emissions, and demonstrate the potential for renewable energy penetration in power systems. This has been achieved through the substitution of diesel based generation with renewables such as wind and solar and the integration of enabling technologies such as storage and a dynamic frequency control resistor. The projects completed to date include:
The results achieved to date include 85% instantaneous renewable energy penetration and an annual contribution of over 35%, forecast to increase to 45% post commissioning of the resistor. Hydro Tasmania has designed a further innovative program of renewable energy and enabling technology projects. The proposed King Island Renewable Energy Integration Project, which recently received funding support from the Australian Federal Government, is currently under assessment to be rolled out by Hydro Tasmania (including elements with our partners CBD Energy) by 2012. These include:
This program of activities aims to achieve a greater than 65% long term contribution from renewable energy sources (excluding biodiesel contribution), with 100% instantaneous renewable energy penetration. The use of biodiesel will see a 95% reduction in greenhouse gas emissions. The projects will address the following issues of relevance to small and large scale power systems aiming to achieve high levels of renewable energy penetration:
Longitudinal corneal hysteresis changes predict structural progression in medically controlled, early-to-moderate, open-angle glaucoma with a history of refractive surgery
Authors: Lee Jihei Sara , Bae Hyoung Won , Kim Chan Yun , Lee Sang Yeop 
Published: January 2025

BackgroundThe present study aims to identify the relationship between longitudinal changes in corneal hysteresis (CH) and progressive retinal nerve fibre layer (RNFL) thinning in a cohort of medically controlled, early-to-moderate open-angle glaucoma (OAG) patients with a history of laser refractive surgery (LRS).MethodsA total of 123 consecutive eyes with a diagnosis of medically controlled (peak intraocular pressure (IOP)<18 mm Hg), early-to-moderate OAG with a history of LRS underwent measurements of CH, corneal-compensated intraocular pressure (IOPcc) and RNFL thicknesses every 6 months. Linear models were used to investigate the relationship between CH change and RNFL thickness change over time.ResultsOf 123 eyes, 30 eyes (24.4%, 42.9±9.3 years, 36.7% males) demonstrated RNFL loss (93 eyes no progression, 44.4±9.6 years, 30.1% males). No statistically significant difference was found in IOP, but significantly greater decrease in CH was noted in the progression group (−2.525% baseline (95% CI −4.974 to −0.076) vs 1.068% baseline (95% CI, −0.322 to 2.458); p=0.013). Relative CH change was greater for more advanced stage of OAG among the progression group. Patients with the greatest relative CH decrease over time was 1.7 times more likely to present RNFL loss (HR 1.705, 95% CI 1.113 to 2.611, p=0.014).ConclusionsLongitudinal decrease in CH over time was greater in those showing structural progression than those without progression among medically controlled, early-to-moderate OAG with a history of LRS. Decrease in CH was significantly associated with faster RNFL loss. Larger CH changes indicate a higher risk of OAG progression in those with a history of LRS.
Effect of social support on memory ageing of middle-aged and older cancer survivors: a marginal structural modelling approach
Authors: Westrick Ashly C , Yu Xuexin , O’Shea Brendan , Kobayashi Lindsay C 
Published: January 2025

BackgroundWhile social support is associated with better cognitive health among cancer-free individuals, this relationship is understudied among cancer survivors. We investigated whether overall social support before and after a cancer diagnosis is related to post-diagnosis memory ageing, overall and by sex/gender.MethodsData were from 2044 cancer survivors in the US Health and Retirement Study (HRS; n=1395) and English Longitudinal Study of Ageing (ELSA; n=649) from 2006 to 2018. Incident cancer diagnoses and memory function (immediate and delayed word recall) were assessed biennially. Social support was assessed every 4 years in the HRS and biennially in ELSA. We established three time points relative to a cancer diagnosis: pre-diagnosis (the wave prior to cancer diagnosis), time 1 post-diagnosis (the first wave after a cancer diagnosis) and time 2 post-diagnosis (the second wave after a cancer diagnosis). Multivariable-adjusted marginal structural models incorporating inverse probability of treatment and attrition weights estimated the relationship between overall social support and memory function post-diagnosis.ResultsPrior to a cancer diagnosis, 45.1% of participants reported high social support. Cancer survivors reporting higher social support at time 2 had better memory function post-diagnosis than those with lower social support (0.14 SD units; 95% CI: 0.03 to 0.24) which was stronger among women (0.18 SD units; 95% CI: 0.02 to 0.34) than men (0.10 SD units; 95% CI: −0.03 to 0.24).ConclusionsSocial support may help promote memory function after a cancer diagnosis in mid-to-later life. Further studies with a larger sample size and differentiation of social support are warranted.
The Current Challenges of Software Engineering in the Era of Large Language Models
Authors: Gao Cuiyun , Hu Xing , Gao Shan , Xia Xin , Jin Zhi 
Published: January 2025

With the advent of large language models (LLMs) in the artificial intelligence (AI) area, the field of software engineering (SE) has also witnessed a paradigm shift. These models, by leveraging the power of deep learning and massive amounts of data, have demonstrated an unprecedented capacity to understand, generate, and operate programming languages. They can assist developers in completing a broad spectrum of software development activities, encompassing software design, automated programming, and maintenance, which potentially reduces huge human efforts. Integrating LLMs within the SE landscape (LLM4SE) has become a burgeoning trend, necessitating exploring this emergent landscape’s challenges and opportunities.
The paper aims at revisiting the software development life cycle (SDLC) under LLMs, and highlighting challenges and opportunities of the new paradigm. The paper first summarizes the overall process of LLM4SE, and then elaborates on the current challenges based on a through discussion. The discussion was held among more than 20 participants from academia and industry, specializing in fields such as software engineering and artificial intelligence. Specifically, we achieve 26 key challenges from seven aspects, including software requirement & design, coding assistance, testing code generation, code review, code maintenance, software vulnerability management, and data, training, and evaluation. We hope the achieved challenges would benefit future research in the LLM4SE field.
MTHFD2 Enhances cMYC O-GlcNAcylation to Promote Sunitinib Resistance in Renal Cell Carcinoma
Authors: Liu Jinwen , Huang Gaowei , Lin Hao , Yang Rui , Zhan Wenhao , Luo Cheng , Wu Yukun , Chen Lingwu , Mao Xiaopeng , Chen Junxing , Huang Bin 
Published: January 2025

Abstract
Sunitinib is a first-line targeted therapy for patients with renal cell carcinoma (RCC), but resistance represents a significant obstacle to the treatment of advanced and metastatic RCC. Metabolic reprogramming is a characteristic of RCC, and changes in metabolic processes might contribute to resistance to sunitinib. Here, we identified MTHFD2, a mitochondrial enzyme involved in one-carbon metabolism, as a critical mediator of sunitinib resistance in RCC. MTHFD2 was elevated in sunitinib resistant RCC cells, and loss of MTHDF2 conferred sensitivity to sunitinib. In patients, MTHFD2 was highly expressed in RCC and was associated with poor outcomes. Mechanistically, MTHFD2 stimulated UDP-GlcNAc biosynthesis and promoted cMYC O-GlcNAcylation by driving the folate cycle. O-GlcNAcylation enhanced cMYC stability and promoted MTHFD2 and CCND1 transcription. Targeting MTHFD2 or cyclin D1 sensitized tumor cells to sunitinib in vitro and in vivo. Consistently, development of a peptide drug capable of efficiently degrading MTHFD2 enabled reversal of sunitinib resistance in RCC. These findings identify a noncanonical metabolic function of MTHFD2 in cell signaling and response to therapy and reveal the interplay between one-carbon metabolism and sunitinib resistance in RCC. Targeting MTHFD2 could be an effective approach to overcome sunitinib resistance.