bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telehealth interventions in patients with chronic liver diseases: A systematic review
Authors: Muftah Abdullah A. , Banala Chaitra , Raasikh Taaj , Jamali Taher , Bustamante Gabriel , Cholankeril George , Kanwal Fasiha , Flores Avegail , Hernaez Ruben 
Published: January 2023

Background and Aim:
Telehealth interventions may improve access to care, disease-specific, and quality outcomes in chronic liver diseases (CLDs). We aimed to systematically evaluate outcomes of telehealth interventions in CLDs.

Materials and Methods:
We used key terms and searched PubMed/EMBASE from inception to January 10, 2022. Two authors independently screened abstracts. Disagreements were resolved by a third reviewer. We included any type of CLD, including posttransplant patients, and extracted outcomes as defined by authors for each etiology of CLD (sustained virological response in HCV or weight loss in NAFLD). Meta-analysis was not performed because of the heterogeneity of data. Quality assessment was performed using the Newcastle-Ottawa Scale for observational studies and the Cochrane Risk of Bias tool for clinical trials.

Results:
Of 4250 studies screened, 43 met the inclusion criteria. Of these, 28 reported HCV treatment outcomes. All studies showed no statistically significant differences between sustained virological response rates in TH groups compared with control groups or historic cohorts. Eight studies evaluating liver transplant-related processes and outcomes demonstrated improved rates of transplant evaluation and referrals and decreased short-term readmission rates. Three randomized controlled trials and 1 observational study on NAFLD showed improved weight loss outcomes. One retrospective study showed reduced mortality risk in CLD patients with at least 1 TH encounter.

Conclusions:
TH interventions in patients with CLDs consistently show equivalent or improved clinical outcomes compared with traditional encounters. TH in CLDs can bridge the gap in access while maintaining the quality of care for underserved populations.
SERPINA12 promotes the tumorigenic capacity of HCC stem cells through hyperactivation of AKT/β-catenin signaling
Authors: Yu Huajian , Zhou Lei , Loong Jane H.C. , Lam Ka-Hei , Wong Tin-Lok , Ng Kai-Yu , Tong Man , Ma Victor W.S. , Wang Yanyan , Zhang Xiang , Lee Terence K. , Yun Jing-Ping , Yu Jun , Ma Stephanie 
Published: January 2023

Background and Aims:
HCC is an aggressive disease with poor clinical outcome. Understanding the mechanisms that drive cancer stemness, which we now know is the root cause of therapy failure and tumor recurrence, is fundamental for designing improved therapeutic strategies. This study aims to identify molecular players specific to CD133+ HCC to better design drugs that can precisely interfere with cancer stem cells but not normal stem cell function.

Approach and Results:
Transcriptome profiling comparison of epithelial-specific “normal” CD133+ cells isolated from fetal and regenerating liver against “HCC” CD133+ cells isolated from proto-oncogene-driven and inflammation-associated HCC revealed preferential overexpression of SERPINA12 in HCC but not fetal and regenerating liver CD133+ cells. SERPINA12 upregulation in HCC is tightly associated with aggressive clinical and stemness features, including survival, tumor stage, cirrhosis, and stemness signatures. Enrichment of SERPINA12 in HCC is mediated by promoter binding of the well-recognized β-catenin effector TCF7L2 to drive SERPINA12 transcriptional activity. Functional characterization identified a unique and novel role of endogenous SERPINA12 in promoting self-renewal, therapy resistance, and metastatic abilities. Mechanistically, SERPINA12 functioned through binding to GRP78, resulting in a hyperactivated AKT/GSK3β/β-catenin signaling cascade, forming a positive feed-forward loop. Intravenous administration of rAAV8-shSERPINA12 sensitized HCC cells to sorafenib and impeded the cancer stem cell subset in an immunocompetent HCC mouse model.

Conclusions:
Collectively, our findings revealed that SERPINA12 is preferentially overexpressed in epithelial HCC CD133+ cells and is a key contributor to HCC initiation and progression by driving an AKT/β-catenin feed-forward loop.
Menstrual Status and Pregnancy in Former Elite Long-Distance Runners With Menstrual Disorders
Authors: Fujita Yuki , Sasaki Eiji , Yoneda Katsuro , Kinugasa Shoko , Oishi Maika , Tsuda Eiichi , Ishibashi Yasuyuki , Umeda Takashi 
Published: January 2023

Objective:
To estimate the ratio of menstrual abnormalities, infertility, and other problems related to pregnancy and childbirth in former long-distance runners. We hypothesized that the female athlete triad during an athletic career affects future fertility and childbearing in former athletes.

Design:
Cross-sectional study.

Setting:
Participants of the All Japan University Women's Ekiden.

Participants:
Female former athletes who competed at national level were asked to complete the questionnaire; 137 valid responses were obtained.

Independent Variables:
Age at menarche and at the onset of pregnancy, history of amenorrhea and gynecological disorders, and lowest body mass index (BMI) during their athletic career.

Main Outcome Measures:
Menstrual status, history of pregnancy and childbirth, any related infertility treatment and problems, and history of stress fractures.

Results:
The mean age at menarche was 13.3 ± 2.2 (range, 10-25) years. Five athletes (3.6%) had primary amenorrhea. Eleven of the 137 participants (8.0%) required treatment for infertility. Sixty participants had 121 pregnancies, of which 5 were yet to deliver during the survey. Fifteen of 116 pregnancies (12.9%) ended in miscarriage, induced abortion, or stillbirth. Logistic regression analysis showed that the factors related to “infertility treatment” were age at the onset of pregnancy (P = 0.047) and higher BMI during their athletic career (P = 0.032; odds ratio, 2.19).

Conclusions:
The main factor influencing infertility was an older age at the time of pregnancy, similar to that observed in the general population. Amenorrhea or being underweight during their athletic career was not associated with problems related to conception and childbirth.
The use of the time-to-event index (Tevent) to compare the negative impact of COVID-19 on public health among continents/regions in 2020 and 2021: An observational study
Authors: Chuang Hua-Ying , Wu Hing-Man , Chien Tsair-Wei , Chou Willy , Chen Szu-Hau 
Published: January 2023

Background:
During the COVID-19 pandemic, how to measure the negative impact caused by COVID-19 on public health (ImpactCOV) is an important issue. However, few studies have applied the bibliometric index, taking both infected days (quantity) and impact (damage) into account for evaluating ImpactCOV thus far. This study aims to verify the proposed the time-to-event index (Tevent) that is viable and applicable in comparison with 11 other indicators, apply the Tevent to compare the ImpactCOVs among groups in continents/countries in 2020 and 2021, and develop an online algorithm to compute the Tevent-index and draw the survival analysis.

Methods:
We downloaded COVID-19 outbreak data of daily confirmed cases (DCCs) for all countries/regions. The Tevent-index was computed for each country and region. The impactCOVs among continents/countries were compared using the Tevemt indices for groups in 2020 and 2021. Three visualizations (i.e., choropleth maps, forest plot, and time-to-event, a.k.a. survival analysis) were performed. Online algorithms of Tevent as a composite score to denote the ImpactCOV and comparisons of Tevents for groups on Google Maps were programmed.

Results:
We observed that the top 3 countries affected by COVID-19 in 2020 and 2021 were (India, Brazil, Russia) and (Brazil, India, and the UK), respectively; statistically significant differences in ImpactCOV were found among continents; and an online time-event analysis showed Hubei Province (China) with a Tevent of 100.88 and 6.93, respectively, in 2020 and 2021.

Conclusion:
The Tevent-index is viable and applicable to evaluate ImpactCOV. The time-to-event analysis as a branch of statistics for analyzing the expected duration of time until 1 event occurs is recommended to compare the difference in Tevent between groups in future research, not merely limited to ImpactCOV.
Traditional Chinese exercise for non-valvular atrial fibrillation: A protocol for systematic review and meta-analysis
Authors: Wang Te , Jin Hongguang , Wang Yiqiang , Liu Meixi , Liu Huan , Zhu Xing , Guo Wenping , Fan Chunhui , Huang Yongsheng , Jiang Lihong 
Published: January 2023

Introduction:
Traditional Chinese exercises have become an important part of cardiac rehabilitation. It can coordinate the essence, qi, and spirit of the human body, and has the functions of promoting joints, stretching muscles and bones, ventilating and blood circulation, so as to achieve the balance between hardness and softness, and between yin and yang. We hope that the research results based on systematic review and meta-analysis will provide a theoretical basis for the treatment of atrial fibrillation (AF) with traditional Chinese exercise.

Methods:
The systematic review will be performed according to the Cochrane Handbook for Systematic Reviews of Interventions. The protocol is being reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols Statement. An literature search strategy will be developed and adapted for 9 databases. Searches will be run from the database inception until the date of the search implementation and be updated before the review is completed. Meta analysis will be performed using Review Manager 5.3 and R packages.

Conclusion:
This protocol introduces a systematic review and meta-analysis of traditional Chinese exercises in the treatment of nonvalvular AF and will clarify the efficacy and safety of traditional Chinese exercises in the treatment of AF. This will further provide theoretical support for clinical treatment of AF.
Efficacy of recombinant human bone morphogenetic protein-2 for bone regeneration in alveolar defects: A protocol for systematic review and meta-analysis
Authors: Ma Xudong , Ju Xueqi , Shen Juehui , Zheng Lala 
Published: January 2023

Background:
There is still a lack of credible evidence in the literature regarding the effectiveness of recombinant human bone morphogenetic protein 2 (rhBMP-2) in bone regeneration of alveolar bone defects. Therefore, the purpose of this study is to evaluate the efficacy and safety of rhBMP-2 in autogenous bone graft in bone regeneration of alveolar bone defects and to provide basis for clinical practice.

Methods:
As of March 2023, two independent investigators will identify target literature by searching seven major databases (EMBASE, Google Scholar, PubMed, Cochrane Library, Wan Fang, CNKI, and Web of Science). All clinical cohort studies evaluating the efficacy of rhBMP-2 will be included. The outcomes of the study include changes in the depth of the dental pocket at the involved site, increased clinical attachment levels, patient satisfaction, and adverse events. The Cochrane risk of bias tool will be independently used to evaluate the risk of bias of included randomized cohort studies by two reviewers. A modified version of the Downs and Black tool is adopted to evaluate the quality of nonrandomized cohort studies.

Results:
We hypothesized that rhBMP-2 plays an active role in bone regeneration in alveolar bone defects.

Conclusions:
It is worthy to critically review the evidence of the assessment of rhBMP-2 to inform clinical practice.
Acupuncture for postoperative pain of lumbar disc herniation: A systematic review and meta-analysis
Authors: Zhang Weidong , Liu Huan , Le Xuezhen , Song Kunyu , Yang Fo , Cui Zhenhai , Zhao Wenhai 
Published: January 2023

Background:
Evidence for the effects of acupuncture on postoperative pain of Lumbar disc herniation (LDH) is inconsistent. We conducted this systematic review and meta-analysis to evaluate the efficacy of acupuncture for postoperative pain of LDH.

Methods:
We performed a comprehensive search on PubMed, Embase, Web of Science, Cochrane Central, and four Chinese databases (CNKI, Wan Fang, CBMdisc, and VIP) for articles published before September 2021. The data extraction table was made for the ten included studies, and the risk of bias was assessed using the Cochrane collaboration tool, followed by statistical analysis using RevMan 5.3.

Results:
A total of ten studies involving 838patients were included. The statistical meta-analysis showed that acupuncture treatment was significantly better than drugs in improving cure rate (OR = 2.24, 95% CI = [1.58, 3.19], P < .00001) and the total effectiveness rate (OR = 4.85, 95% CI = [2.59, 9.08], P < .00001). And the results from the meta-analysis showed that acupuncture group was superior to control group in debasing visual analog scale score (MD = −1.26, 95% CI = [−1.72, −0.79], P < .00001) and improving Japanese Orthopaedic Association score (MD = 4.21, 95% CI = [1.53, 6.90], P < .00001). In addition, acupuncture was statistically significantly better than drugs (OR = 0.27, 95% CI = [0.11, 0.62], P = .002) in the incidence of adverse events, However, there was no statistically significant difference between acupuncture and rehabilitation (OR = 0.36, 95% CI = [0.07, 1.98], P = .24).

Conclusion:
Acupuncture is an effective and safe treatment for postoperative pain of LDH. It can be recommended to manage patients with postoperative pain of LDH. However, considering the unsatisfactory quality of the included studies, more high-quality randomized controlled trials with a large sample size are needed to elucidate this issue.
A case report of maturity-onset diabetes of the young (MODY12) in a Chinese Han patient with a novel ABCC8 gene mutation
Authors: Wang Yuan , Kang Chao , Tong Qiang , Wang Hui , Zhang Rui , Qiao Qiao , Sang Qian , Wang Xiaocui , Wang Jian , Xu Jing 
Published: January 2023

Rationale:
Maturity onset diabetes of the young (MODY) is the most common type of monogenic diabetes, characterized by autosomal dominant inheritance, the age of onset is often <25 years old, and the clinical manifestations are atypical. MODY12 is caused by a rare missense mutation of adenosine triphosphate (ATP)-binding cassette transporter subfamily C member 8 (ABCC8) gene and more than 50 ABCC8 variants were associated with MODY12.

Patient concerns:
The patient was a 30-year-old Chinese Han man. He was overweight with a poor control of blood glucose.

Diagnoses:
The patient was diagnosed with MODY12.

Interventions:
The patient was given glimepiride (4 mg/d) with diet and exercise therapy to reduce blood glucose and weight.

Outcomes:
The level of fasting blood glucose and C-peptide was improved after 1 year treatment as well as body weight.

Lessons:
A Chinese Han adult with a heterozygous missense mutation c.3976G > A (p.Glu1326Lys) was diagnosed with MODY12, which was the new pathogenic mutation for the disease. This report expands the spectrum of variants causing MODY12 and reduces misdiagnosis.
Effectiveness of interleukin-17A inhibitors in patients with ankylosing spondylitis: A protocol for systematic review and meta-analysis
Authors: Yan Mingguang , Fang Xiao , Guo Jianjun , Yin Weibing 
Published: January 2023

Background:
Ankylosing spondylitis is a chronic immune-mediated inflammatory arthritis. Interleukin-17A (IL-17A) inhibitors is recognized as a novel therapeutic target for ankylosing spondylitis. However, there is still a lack of high-quality research evidence regarding the issues. Therefore, we performed a protocol for systematic review and meta-analysis to evaluate the efficacy and safety of IL-17A inhibitors in patients with ankylosing spondylitis.

Methods:
This protocol will be conducted under the preferred reporting items for systematic reviews and meta-analyses protocols (PRISMA-P) guidelines. Furthermore, the study has been registered on PROSPERO (CRD42022375885). The following electronic databases will be searched regardless of language and publication status: Pubmed, MEDLINE, EMBASE, China Biomedical Database, China National Knowledge Infrastructure, VIP Database, and Wanfang Database. Cochrane “bias risk” tool is used to assess the bias risk of the quality of the included literature. Data synthesis and statistical analysis will be performed using the RevMan 5.3 (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) software.

Results:
A synthesis of current evidence of IL-17A inhibitors for ankylosing spondylitis will be shown in this protocol.

Conclusion:
This review can provide convincing evidence to help clinicians make decisions when dealing with ankylosing spondylitis.
Effects of subarachnoid extension following intracerebral hemorrhage: A systematic review and meta-analysis
Authors: Liu Tingzhi , Mai Jilin , Pang Linlin , Huang Ya , Han Jing , Su Weixiang , Chen Kaichang , Qin Peiying 
Published: January 2023

Background:
The effects of subarachnoid extension (SAHE) following intracerebral hemorrhage (ICH) have not yet been fully understood. We conducted a systematic review and meta-analysis of published literature on this topic to better understand the effects of SAHE.

Methods:
PubMed, Embase, and Cochrane databases were thoroughly searched from inception to October 16, 2022 to identify studies that evaluated the association between SAHE and mortality and worse functional outcomes in primary ICH. Crude odds ratios (cOR) and adjusted odds ratios (aOR) with 95% confidence interval (CI) were calculated to compare the endpoints.

Results:
Three studies with 3368 participants were eventually included in the analysis. In the short-term follow-up of the primary endpoint, no association was observed between SAHE and mortality (cOR: 0.51, 95% CI: 0.01–28.19; aOR: 2.31, 95% CI: 0.72–7.45). In the long-term follow-up of the primary endpoint, SAHE was associated with a significantly increased mortality of patients with primary ICH (cOR: 3.00, 95% CI: 2.27–3.98); however, only 1 study provided the values of aOR and 95% CI and showed that SAHE was not associated with increased mortality (aOR: 1.14, 95% CI: 0.71–1.83). For the secondary endpoint, the data of only 1 study on major disability (modified Rankin Scale = 3–5) were available, and the results revealed that SAHE increased the probability of major disability, but not after adjusting for baseline hematoma volume.

Conclusion:
There is insufficient evidence to demonstrate the correlation between SAHE and mortality and worse functional outcomes in primary ICH. The validation of this correlation requires further studies as the potential effect and mechanisms of SAHE remain unclear.
The effect of vitamin D supplementation on glycemic status and C-reactive protein levels in type 2 diabetic patients with ischemic heart disease: A protocol for systematic review and meta-analysis
Authors: Chai Xuxia , Jin Yonghe , Wei Yongmei , Yang Rong 
Published: January 2023

Background:
Vitamin D might be beneficial in diabetic patients with ischemic heart disease through its favorable effect on metabolic profiles and biomarkers of inflammation and oxidative stress. We performed a protocol for systematic review and meta-analysis to assess whether vitamin D supplementation could improve glucose control and inflammation in type 2 diabetic patients with ischemic heart disease.

Methods:
The proposed systematic review and meta-analysis will conform to the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols. Seven electronic databases including Web of Science, Embase, PubMed, Wanfang Data, Scopus, Science Direct, Cochrane Library were searched in October 2022 by 2 independent reviewers. The risk of bias assessment of the included studies was assessed using the tool recommended in the Cochrane Handbook for Systematic Reviews of Interventions (version 5.1.0). Data analysis was performed with Review Manager Software (RevMan Version 5.4, The Cochrane Collaboration, Copenhagen, Denmark).

Results:
This study will provide a high-quality synthesis to assess the effectiveness and safety of vitamin D supplementation on type 2 diabetic patients with ischemic heart disease.

Conclusion:
This systematic review may lead to several recommendations, for both patients and researchers, as which is the best therapy for type 2 diabetic patients with ischemic heart disease and how future studies need to be designed, considering what is available now and what is the reality of the patient.
INSR novel mutations identified in a Chinese family with severe INSR-related insulin resistance syndromes: A case report
Authors: Yu Lu , Yu Fang , Ma Zongrui , Lu Huilin , Luo Jian , Sun Ting , Liu Qin , Gan Shenglian 
Published: January 2023

Rationale:
Severe insulin receptor gene (INSR)-related insulin resistance syndromes (SIR) include Donohue syndrome (DS), Rabson–Mendenhall syndrome (RMS), and type A insulin resistance. The incidence of DS is about 1 in 4 million births. We identified novel INSR mutations (c.2246delG and c.2646 + 5G > A) in a patient with SIR, which expanded the variant spectrum and helped to improve the understanding of the diagnosis and treatment of this condition.

Patient concerns:
A 10-year-old Chinese boy was admitted to the hospital for deepening skin color. He presented with growth retardation, peculiar facial features, acanthosis nigricans, hypertrichosis, extremely high insulin levels, fasting hypoglycemia, and postprandial hyperglycemia, Whole-exome gene testing suggested compound heterozygous mutations in INSR (c.2246delG and c.2646 + 5G > A).

Diagnosis:
The diagnosis was SIR. What’s more, based on the phenotypic and biographical results, this child did not present typical RMS and DS but rather an intermediate phenotype between the 2 conditions.

Interventions:
On the basis of a sensible diet and exercise, the patient was prescribed metformin (250 mg) at breakfast and lunch, which was increased to 500 mg after 1 month.

Outcomes:
After 2 months of treatment, the patient’s glycated hemoglobin (HbA1c) levels decreased to 6% but his insulin resistance did not improve significantly.

Lessons:
In children who are not obese but with severe insulin resistance, growth retardation, hirsutism, and hyperglycemia, genetic testing should be performed for early diagnosis, active treatment, and follow-up.
Maximizing opportunities for kidney transplantation in older adults
Authors: Fleetwood Vidya A. , Caliskan Yasar , Rub Fadee Abu Al , Axelrod David , Lentine Krista L. 
Published: January 2023

Purpose of review
To summarize the current state of evidence related to the outcomes of older adults who need and receive kidney transplants, and strategies to facilitate appropriate transplant access in this at-risk group.

Recent findings
Older adults are a rapidly growing subgroup of the kidney transplant waitlist. Compared to younger adults, older kidney transplant recipients have increased mortality after kidney transplant and lower death-censored graft survival. In determining suitability for transplantation in older patients, clinicians must balance procedural and immunosuppression-related risk with incremental survival when compared with dialysis. To appropriately increase access to transplantation in this population, clinicians and policy makers consider candidates’ chronological age and frailty, as well as the quality of and waiting time for a donated allograft. Given risk of deterioration prior to transplant, candidates should be rapidly evaluated, listed, and transplanted using living donor and or less than ideal deceased donor organs when available.

Summary
Access to transplantation for older adults can be increased through targeted interventions to address frailty and reduce waiting times through optimized organ use. Focused study and educational interventions for patients and providers are needed to improve the outcomes of this vulnerable group.