bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic transnasal transsphenoidal management of sellar/suprasellar arachnoid cyst: A case report and literature review
Authors: Matmusaev Maruf , Watanabe Tadashi , Iwami Kenichiro , Akhmediev Tokhir 
Published: April 2023

Background:
Arachnoid cysts (ACs) are collections of cerebrospinal fluids (CSFs) that develop within the arachnoid layer of the meninges. Sellar ACs are comparatively rare. In general, ACs account for approximately 1% of all intracranial mass lesions, and sellar ACs are 3% of all intracranial ACs. An endoscopic transnasal transsphenoidal approach for the treatment of ACs by fenestrating the cyst’s wall and connecting with the subarachnoid space is the most optimal option.

Case Description:
A 74-year-old woman whose sellar AC was diagnosed on magnetic resonance imaging a year ago was admitted to our hospital with complaints of bitemporal hemianopia and diminished visual acuity in the past 2 months. Sellar AC was diagnosed based on the clinical history and presentation, as well as neurologic, endocrinologic, and ophthalmologic examinations, including visual acuity and visual field examination, and additional imaging findings. The patient with a sellar/suprasellar AC was treated by an endoscopic transnasal transsphenoidal approach with cyst drainage and perforation of the lamina terminalis. Postoperatively, the visual disturbances improved markedly. No surgery-related complications occurred.

Conclusion:
The endoscopic transnasal transsphenoidal approach remains a minimally invasive and preferred approach for the treatment of sellar/suprasellar ACs. Hermetically reconstructing the sellar floor is an effective method to prevent CSF leakage.
Spinal mesenchymal chondrosarcoma: A case report of a rare malignant tumor
Authors: Dehneh Younes , Aldabbas Mohannad , Elfarissi Mohammed Alamine , Khoulali Mohamed , Oulali Noureddine , Moufid Faycel 
Published: April 2023

Background:
Mesenchymal chondrosarcoma is an uncommon malignant variant of chondrosarcoma that mainly affects the bones and cartilaginous tissues, but may rarely involve the spine. Careful preoperative planning for surgical tumor removal and spine reconstruction is mandatory and must be based on oncologic and surgical staging.

Case Description:
Over 1 month, a 16-year-old female became paraplegic with a T9 sensory level and urinary dysfunction. The magnetic resonance imaging revealed an intraspinal extradural T7-T9 mass that was isointense in T1W1 and markedly enhanced with gadolinium. The patient underwent gross-total tumor resection followed by an osteoplastic laminectomy with fusion. The histological examination was consistent with a mesenchymal chondrosarcoma. She had received radiation and chemotherapy. One year later, she was readmitted for tumor recurrence with multiple metastases involving L1, the lung, and peritoneum. Despite full course of radiotherapy and chemotherapy, she died after 6 months of the second surgery.

Conclusion:
Total resection of mesenchymal chondrosarcomas is the gold standard for treatment and is typically followed by radiation and/or chemotherapy. However, the status of residual tumor, local extension, and or metastases best determine the overall survival which may prove extremely limited.
Hypofractionated radiotherapy of patients with glioblastoma: the first experience in Ukraine and prospects view
Authors: Gryazov Andrey B. , Glavatskyi Oleksandr Y. , Chuvashova Olga Y. , Zemskova Oksana V. , Andriichenko Olena G. , Kruchok Iryna V. , Griazov Andrii A. , Spasichenko Igor P. , Khmelnytskyi Hennadii V. , Shuba Iryna M. , Stuley Volodymyr A. 
Published: April 2023

Objective: To assess the survival of patients (pts) with newly diagnosed glioblastoma (GBM) in groups with hypofractionated regime radiotherapy, standard fractionationated regime radiotherapy and whole brain irradiation.Materials and methods: A retrospective non-randomized single-center study of 205 pts with GBM grade 4 according to the WHO classification treated in Romodanov Neurosurgery Institute named after Acad. A.P. Romodanov National Academy of Medical Science of Ukraine (2014–2020). The mean age of pts 53.8 years (95% CI 52.1 - 55.5); there were 114 men (55.6%) and 91 women (44.4%). According to the regimen radiotherapy (RT), pts were divided into 3 groups: 49 (23.9%) pts (standard RT: 2.0 Gy per fraction in 30 fractions, total dose 60.0 Gy) – group "sRT", 110 (53.7%) pts (hypofractionated RT: 3.5 Gy per fraction in 15 fractions, total dose 52, 5 Gy) - group "hRT", 46 (22.4%) pts – group "WBRT" (whole brain radiation). Differences in progression-free survival (PFS) and overall survival (OS) between the three groups were analyzed using Kaplan–Meier survival curve, log-rank test and Pearson Chi-square test.Results: The median OS is 15,0 (95% CI 14,1 – 17,1), 16,5 (95% CI 14,1 – 18,8) and 8,7 (95% CІ 7,5 – 9,5) months for sRT, hRT and WBRT, respectively. There is a significant difference in OS for sRT and hRT compared to WBRT (p=0.00000), without difference in OS between sRT and hRT (p=0.06757). The median PFS in sRT and hRT does not differ significantly: sRT – 9.0 (95% CI 9.0 - 10.0) months; hRT – 9.0 (95% CI 8.0 - 10.0) months. The median OS for WBRT is 5.1 (95% CI 4.0 - 6.0) months. There is a significant difference in PFS for sRT and hRT compared to the WBRT (p=0.00000), without difference in PFS between sRT and hRT (p=0.43374). The risk of death for WBRT compared to sRT is 2.5 times higher (HR 2.5 [95% CI, 1.45 - 4.46)) and 3.5 times higher compared to the hRT group (HR 3.5 [95% CI, 2.09-5.88)). The risk of progression for WBRT is 2.8 times higher (HR 2.78 [95% CI, 1.63-4.74)) compared to sRT, and 3.1 times higher (HR 3.12 [95% CI, 1.91-5.10)) compared to hRT.The broad implementation of hRT into clinical practice is specific to all modern radiation oncology. This trend is currently underway due to the specific positive clinical effects of hRT, which are discussed in detail in our publication.Conclusions: Our study demonstrates comparable survival outcome between sRT and hRT groups. This is an argument in favor of the feasibility of using hRT as a part of multimodal GBM treatment in terms of oncological outcomes. Further studies are needed to identify specific stratification groups of GMB patients with the greatest survival and quality of life benefits due to hRT.
JOINT ACTIVITY OF INDUSTRIAL ENTERPRISES AND UNIVERSITIES TO IMPLEMENT NEW TECHNOLOGIES
Authors: Чайков М.Ю. 
Published: April 2023

В статье рассмотрен успешный опыт научного и бизнес-сотрудничества промышленного предприятия из Екатеринбурга (машиностроительный завод) и Казанского национального исследовательского технического университета им. А.Н. Туполева-КАИ. Автор на конкретных примерах показывает, как совместная работа специалистов данных организаций привела к созданию новых научных открытий и технических инноваций.
We look at the best practice of scientific and business cooperation of a machine-building company from Yekaterinburg and Kazan National Research Technical University named after A. Tupolev. We give examples of how the joint efforts of the specialists from the organizations in question contribute to scientific discoveries and technical innovations.
POWER SHELL ELEMENTS: DYNAMIC MATHEMATICAL MODELS (OVERVIEW)
Authors: Чернусь Павел П. , Чернусь Пётр П. 
Published: April 2023

В статье приведен обзор силовых оболочковых элементов (СОЭ) и их конструктивных реализаций (пневмомускул, баллонный цилиндр) с точки зрения построения математических моделей ‒ дифференциальных уравнений, описывающих временные зависимости между перемещением и усилием на выходе СОЭ и расходом на его входе. Показано, что использование указанных элементов может быть описано с помощью математического моделирования, что облегчает синтез системы управления.
We present an overview of power shell elements (PSE) and their constructive implementations (pneumatic artificial muscles, balloon cylinder) from the point of view of constructing mathematical models ‒ differential equations describing the time dependences between displacement and force at the output of the PSE and the flow rate at its input. We demonstrate that the use of the elements in question can be described using mathematical modeling, which facilitates the synthesis of the control system.
Experimental evaluation of the effect of supplementary nutrition and glutargine on regenerative properties
Authors: Kushta A.A. , Shuvalov S.M. 
Published: April 2023

The problem of alimentary dystrophy, which develops due to various reasons, is an urgent problem, especially in patients with tumors of the head and neck. After removal of tumors, patients have large postoperative defects that interfere with proper nutrition. Therefore, to provide the body with the necessary nutrients, enteral nutrition is especially important. In addition, successful wound healing requires adequate blood supply and sufficient levels of nutrients, which depends on the general condition of the body and the patient's diet. However, the degree of reparative processes correlates not only with the number of substrates of anabolism, but also with the proper functioning of the liver. The aim of our study was to investigate the effect of the drug for enteral nutrition and glutargin on the reparative properties of rats’ wounds on the background of partial food deprivation. The study was performed on 60 adult male rats weighing 280±20 grams of the Wistar line, with a mean age of 15 weeks. Prior to the experimental study the regenerative properties of the animals were on partial food deprivation. On the 10th day, a wound with a diameter of 2.0 cm was inflicted. Then the rats were divided into 4 groups: 1 group (control) received food according to physiological needs; Group 2 (food derivation (FD)); Group 3 (FD+enteral nutrition); Group 4 (FD+enteral nutrition +glutargin). Against the background of alimentary dystrophy (20% weight loss) on the first day there was a significant difference in the edges of the wound due to loss of its elasticity. Wound contraction processes up to 14-15 days in all observation groups were quite active, regardless of the factors of malnutrition with cereals or additional therapeutic diet "Peptamen" or in combination with glutargin. Thus, every three days the area of wounds decreased by 30-40 mm2 on an average. Only on the 15th-17th day the difference in the rate of wound contraction becomes visible and statistically significant. Thus, on the 15th day the largest wounds were in the second group on the background of partial food deprivation (p<0.05), at the same time in the first (control) and in the fourth groups the average area was almost equal (p>0.05). The smallest (p<0.05) area of wounds was observed in the first group (control) on the 15th day. On the 17th day wound healing was observed in the fourth group (FD+enteral nutrition+glutargin), despite the expansion of wounds on the first day. A pronounced therapeutic effect correcting alimentary dystrophy was obtained with enteral nutrition (Peptamen) and glutargin at a dose of 50 mg/kg, where the wounds healed simultaneously with those in the first (control) group, ie in animals with a normal diet, indicating a high effectiveness of the proposed method of correction of alimentary dystrophy. Enteral nutrition alone (Peptamen) was also effective, as evidenced by the small size of virtually epithelialized wounds on the 17th day.
The significance of assessment the relationship between the level of 25-(OH) vitamin D and excessive body weight in women on preconceptional period and during pregnancy
Authors: Maksymenko L.R. , Perkhulyn O.M. , Drohomyretska N.V. , Henyk N.I. 
Published: April 2023

The goal of this study was to determine the association between the level of 25-(OH) vitamin D and excessive body weight in women on preconceptional period and during gestation. There were studied 117 women. The first group included 68 overweight women (body mass index (BMI) 25.0-29.9 kg/m2), the second – 49 with normal body weight (BMI 18.5-24.9 kg/m2) before prepregnancy. Anthropometry was performed, BMI (kg/m2) by Quetelet formula. The 25-(OH) vitamin D blood serum level was studied by immunoenzymatic method. Fasting blood serum levels of glucose, insulin were determined by the immunoenzymatic method, insulin resistance index was calculated, serum concentrations of triglycerides, total cholesterol, high, low and very low density lipoproteins were determined. The results were statistically analyzed using Statistica 10 (Serial Number: STA999K347150-W) and MEDCALC®. It was found an inverse correlation between the level of vitamin D and BMI (r= – 0.71, p<0.001). Excessive body weight on precon­ceptional period reduces the chances of an adequate level of vitamin D (0.02; 0.00-0.10; p<0.001) and increases the chances of its deficiency (13.11; 4.89-35.30; p<0.001) during early gestational period. It was diagnosed that during pregnancy, the chances of vitamin D deficiency increase in women with normal body weight (3.16; 1.11-9.02; p=0.04), but remain significantly higher in the overweight (6.30; 2.80-14.18; p<0.001). It was shown that insufficiency/deficiency of vitamin D during pregnancy was accompanied by insulin resistance, hyper/dyslipidemia, which are the metabolic basis of gestational complications. The assessment of an inverse relationship between the level of 25-(OH) vitamin D and excessive body weight in women on preconceptional period and the increase of deficiency during pregnancy should be taken into account for the purpose of laboratory determination of the vitamin at the stage of pregnancy planning for the appointment of therapeutic correction.
Correlation between resilience and cognitive functioning in veterans with traumatic brain injury
Authors: Assonov D.O. 
Published: April 2023

Resilience in veterans with brain trauma in remote period has received considerable attention over the past years. Cognitive functioning is described among factors that may influence resilience and included in the modern theoretical models of this positive psychology phenomenon. However, the characteristics of relationship between resilience and cognitive functioning in veterans with traumatic brain injury (TBI) in remote period was not studied empirically. Therefore, the purpose of this study was to gain better understanding of the possible association between resilience and cognitive functioning in Ukrainian war veterans with traumatic brain injury in remote period. This study included 146 veterans who were admitted to two clinical hospitals for war veterans. The Connor-Davidson Resilience Scale and Montreal Cognitive Assessment Scale were used. The present study shows that lower cognitive functioning in total and in several domains is associated with less effective resilience regardless of TBI clinical type (whether it is concussion or mild cerebral contusion). Moreover, such correlation was still present after excluding the effect of age, education and TBI characteristics like number of traumas and time since last TBI. Overall, we found empirical evidence that good cognitive functioning (especially executive functions, memory, attention, abstract thinking, and orientation) is essential for effective resilience in veterans with mild TBI even years after trauma and has more effect on ability to adapt than age, education, and trauma characteristics. Educating veterans to use their cognitive potential and to compensate the restrictions after mild TBI possibly may lead to better overcoming adversities and counteracting the risks of des­adaptation and traumatic events. Therefore, psychological interventions for improving the ability to readapt and recover possibly should consider this relationship and include the component of educating veterans to use their cognitive reserve and compensate limitations to better adapt and thrive. Studies related to such interventions appear to be promising.
Clinical case severe course of coronavirus infection (COVID-19) in a child
Authors: Mateiko H.B. , Matvisiv M.V. , Pylyuk I.I. , Nesterova T.V. , Glushko U.A. 
Published: April 2023

A clinical case of a severe course of coronavirus infection (COVID-19) in an adolescent is described. A 15-year-old patient was admitted to the surgical department with suspicion of acute appendicitis. According to the results of the ultrasound examination of the abdomen it was decided to perform diagnostic laparoscopy, which excluded the presence of acute surgical pathology. The increase of intoxication symptoms and the data of epidemiological anamnesis, concerning the contact with patients with the catarrhal symptoms 3-4 weeks before the disease onset, were the reason for the examination for SARS-CoV-2. On the basis of a positive polymerase chain reaction for SARS-CoV-2 and existing pneumonia according to X-ray examination of the chest, the patient was transferred to an infectious disease hospital. Further examination revealed polyserositis (ascites, pleurisy); acute kidney damage (high levels of urea, creatinine, oliguria); cytolytic syndrome (increased level of aspartate aminotransferase in 1,7 times); high level of C-reactive protein and increased level of procalcitonin, which corresponded to the local infection. After the administration of the first dose of intravenous immunoglobulin the patient's condition has improved significantly. The set of symptoms of multiple organ damage in this clinical case provides grounds for differential diagnosis between coronavirus disease and multisystem inflammatory syndrome in children on the background of the coronavirus infection COVID-19. Based on the diagnostic criteria for multisystem inflammatory syndrome in children presented by the World Health Organization, the Centers for Disease Control and Prevention, the British Medical Journal, the American Academy of Pediatrics, this clinical case can be considered as multisystem inflammatory syndrome.
Тенденції зростання у навколишньому середовищі мікропластику та його вплив на споживачів послуг індустрії гостинності
Authors: Чагайда Андрій Олегович , Тарасюк Галина Миколаївна 
Published: April 2023

У статті проведено аналіз впливу мікропластику на навколишнє середовище. Особлива увага належить дослідженням, які пов’язані з використанням пластикових уапаковок у харчовій індрустрії та сфері гостинності. Щоб повністю оцінити вплив нашої глобальної залежності від пластику на здоров’я, слід не лише враховувати кожен етап його життєвого циклу, але й усі можливі шляхи впливу різноманітних речовин, що використовуються та виділяються впродовж цього життєвого циклу. Проведено дослідження ставлення молоді до проблеми забруднення навколишнього середовища, а саме проведено анкетування 174 респондентів віком від 18 до 23 років (43,2 % – чоловіки, 56,8 % – жінки). Більшість респондентів не усвідомлює реальну величину проблеми, адже мікропластикове сміття ще залишається поза увагою соціальної реклами, яка популяризує вирішення глобальної проблеми забруднення, не акцентуючи увагу на негативних впливах для здоров’я людини. Всупереч факту споживання людьми великої кількості мікропластику, наразі важко сказати, як він впливає на наш організм. Багато досліджень проведено на недостатньо якісному рівні, тому не надають достовірної інформації. Інші ж дані є несистематизованими та не дають побачити повну картину проблеми. Обґрунтовано, що одним із правильних шляхів зменшення негативного впливу на навколишнє середовище, на відміну від захоронення на спеціально відведених полігонах, є перероблення та повторне використання пластику. Така переробка полегшується при окремому збиранні відходів, що відбувається в Україні на данний час без відповідного законодавчого забезпечення та стимулюючих заходів.
HUBUNGAN KARAKTERISTIK DENGAN PERIODE RAWAT INAP PASIEN COVID-19 YANG MENDAPAT TERAPI FAVIPIRAVIR DIRUMAH SAKIT MITRA BANGSA PATI
Authors: Presticasari Hardiyani , Ulfa Nur Farida , Retnowati Eko , Setyowati Endang 
Published: April 2023

Covid-19 merupakan penyakit yang disebabkan oleh virus SARS-CoV-2 (Servere Acute Respiratory Syndrome Coronavirus 2). Penularan Covid-19 sangat cepat sehingga pada tanggal 30 Januari 2020 WHO menyatakan Coronavirus sebagai KKMD. Tingginya kasus Covid-19 membuat kurangnya daya tampung fasilitas kesehatan, sehingga menjadikan pelayanan medis rawat inap kurang optimal dan memadai. Tujuan penelitian ini adalah untuk mengetahui hubungan karakteristik dengan periode rawat inap pada pasien Covid-19 yang mendapat terapi favipiravir di Rumah Sakit Mitra Bangsa Pati. Jenis penelitian observasional analitik dengan pendekatan Retrospective, dilakukan pada bulan Mei-Juni 2021 di Rumah Sakit Mitra Bangsa Pati. Pengambilan sampel secara Purposive Sampling, dan pengumpulan data menggunakan Rekam Medis pasien Covid-19. Jumlah sampel yang diperoleh sebanyak 59 responden, dan analisis data dilakukan dengan cara statistik menggunakan analisi bivariat dengan uji Chi Square.Hasil penelitian didapatkan Jenis kelamin terbanyak yaitu laki-laki 32 pasien (54,2%), usia terbanyak 46-59 berjumlah 29 pasien (49,2%), kemudian pasien Covid-19 paling banyak memiliki komorbid sebanyak 39 pasien (66,1%) dengan penyakit terbanyak adalah diabetes melitus sebanyak 19 pasien (32,2%). Hasil uji Chi Square diperoleh hubungan jenis kelamin dengan lama perawatan nilai p-value: 0,640, hubungan usia dengan lama perawatan nilai p-value 0,806, dan hubungan komorbid dengan lama perawatan nilai p-value 0,301. Tidak terdapat hubungan karakteristik dengan periode rawat inap pasien Covid-19 yang mendapat terapi favipiravir di Rumah Sakit Mitra Bangsa Pati
HUBUNGAN KARAKTERISTIK DENGAN PERIODE RAWAT INAP PASIEN COVID-19 YANG MENDAPAT TERAPI FAVIPIRAVIR
Authors: Setyowati Endang , Muharyanti Rika , Simbara Ari , Dahbul Nura Ali 
Published: April 2023

Background: Covid-19 is a disease caused by the SARS-CoV-2 (Server acute respiratory syndrome coronavirus 2) virus. The transmission of Covid-19 was so fast the on January 30, 2020 WHO declared Coronavirus as KKMD. The high number of cases of Covid-19 has resulted in a lack of capacity for health facilities, thus making inpatient medical services less than optimal and adequate. Objective: To determine the relationship between characteristics with the period of hospitalization of Covid-19 patients receiving favipiravir therapy at the Mitra Bangsa Hospital, Pati.Methods: this type of analytic observational study with a retrospective approach, was conducted in May-June 2021 at Mitra Bangsa Hospital, Pati. Purposive sampling, and data collection using Covid-19 patient medical record. The number of sampels obtained was 59 respondents, and data analysis was carried out statistically using bivariat analysis with Chi Square test.Results: the most gender was male 32 patients (54.2%), the most age 46-59 as many 29 patients (49.2%), then Covid-19 patients had the most comorbidities as many as 39 patients (67.8%) with the most common disiase was diabetes melitus with 19 patiens (32.2%). The result of the Chi Square test showed that there was a relationship between gender with lengts of stay p-value: 0.640, relationship between age with length of stay p-value: 0.806, and comorbid relationship with length of stay p-value: 0.301.Conclusion: There is relationship between characteristics with the period of hospitalization of Covid-19 patients receiving favipiravir therapy at the Mitra Bangsa hospital Pati.Keywords: Covid-19, Favipiravir, Hospitalization