bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apparent Diffusion Coefficient Values Predict Response to Brachytherapy in Bulky Cervical Cancer
Authors: Dong Elizabeth E , Xu Junqian , Kim Joo-Won , Bryan Jason , Appleton Jewel , Hamstra Daniel A , Ludwig Michelle S , Hanania Alexander N 
Published: March 2023

Abstract
Background
Diffusion-weighted magnetic resonance imaging (DWI) provides a measurement of tumor cellularity. We evaluated the potential of apparent diffusion coefficient (ADC) values obtained from post-external beam radiation therapy (EBRT) DWI and prior to brachytherapy (BT) to predict for complete metabolic response (CMR) in bulky cervical cancer.
Methods
Clinical and DWI (b value = 500 s/mm2) data were obtained from patients undergoing interstitial BT with high-risk clinical target volumes (HR-CTVs) > 30cc. Gross tumor was contoured on co-registered T2 weighted images and 90th percentile ADC values were calculated. Patients were stratified by CMR (defined by PET-CT at three months post-BT). Relation of CMR with 90th percentile ADC values and other clinical factors (International Federation of Gynecology and Obstetrics (FIGO) stage, histology, tumor and HR-CTV size, pre-treatment hemoglobin, and age) was assessed both in univariate and multivariate logistic regression analyses. Youden’s J statistic was used to identify a threshold value.
Results
Among 45 patients, twenty-eight (62%) achieved a CMR. On univariate analysis for CMR, only 90th percentile ADC value was significant (p = 0.029) while other imaging and clinical factors were not. Borderline significant factors were HR-CTV size (p = 0.054) and number of chemotherapy cycles (p = 0.078). On multivariate analysis 90th percentile ADC (p < 0.0001) and HR-CTV size (p < 0.003) were highly significant. Patients with 90th percentile ADC values above 2.10 x10− 3 mm2/s were 5.3 (95% CI, 1.34–24.4) times more likely to achieve CMR.
Conclusions
Clinical DWI may serve to risk-stratify patients undergoing interstitial BT for bulky cervical cancer.
Enhanced Body Pigmentation in Leopard Coral Grouper (Plectropomus leopardus) in Response to Environmental Background and Feed Additives
Authors: Chuang Hsiang-Chieh , Nian Cherry T. , Wang Hsu-Hsin , Cheng Ann-Chang 
Published: March 2023

Abstract
Groupers are among the most popular fish commodities worldwide owing to their palatability and appearance. However, their body pigmentation considerably affects their consumer acceptability and pricing, making their culture challenging. The present study aimed to improve the body pigmentation of the leopard coral grouper (Plectropomus leopardus) by investigating the effects of tank color, shading, and feed additives over 28 days. The fish were reared in tanks of different colors (white, black, red, and green), and their net cages were shaded at 0%, 50%, and 80%. The fish reared in the black and green tanks or under 80% shading exhibited the most vibrant skin coloration. Skin color enhancement was tested in feeding trials, during which the fish were fed different concentrations of additives: astaxanthin (0 (control), 1000, 2000, and 3000 mg), vitamin E (1000, 2000, and 3000 mg), and plant extracts (250, 500, and 750 mg) kg-1 of diet. Fish fed the 3,000 mg of astaxanthin kg-1 diet displayed the best pigment enhancement, whereas those fed with vitamin E and plant extracts showed reduced pigmentation. Feeding with different ratios (0%, 10%, 20%, and 30%) of krill meal in the diet showed that body pigmentation was best enhanced by 20–30% krill meal. In conclusion, our results imply that black- and green-colored rearing tanks under 80% shading and a diet with 20–30% krill meal and 3,000 mg astaxanthin kg-1 constitute ideal conditions to enhance the body pigmentation of P. leopardus.
Inter-model Robustness of the Forced Change of the ENSO-Indian Summer Monsoon Teleconnection
Authors: Aneesh Sundaresan , Bódai Tamás 
Published: March 2023

Abstract
Concerning the robustness of the forced response of the ENSO - Indian monsoon teleconnection, three periods can be distinguished. (1) In the late 20th century, the change is insignificant in most models, which does not permit a statement on robustness in this period. This is in stark contrast with earlier claims of a weakening teleconnection allegedly detected from observational data. (2) Furthermore, we find it typical under global warming in the first part of the 21st century that the teleconnection is strengthening or non-decreasing. This considerable robustness is owed to an increasing ENSO variability as well as coupling strength. (3) In the end of the 21st century, however, under strong forcing, the teleconnection change is not robustly modelled: the ENSO variability change is not projected robustly across models, either wrt. the start or the rate of the ENSO variance decline, competing this time with an increase of the coupling strength.
WITHDRAWN: The confined stability region for 40 Ca + ions in a linear Paul trap
Authors: Kazem Basem R. , Saleh Mezher B. , Kazem Basem R. 
Published: March 2023

Abstract
As a result of the current increase in interest in quantum computing and the unrelenting attempt to develop and establish a quantum computer, Many researchers in this field have turned to designing appropriate algorithms or investigating the possibilities of controlling and manipulating the quantum state. One of the most promising techniques involves using single ionized atoms kept in Paul traps. Each ion's internal state represents the lowest quantum informational unit (a qubit). That research used the trapped ions 40Ca + to illustrate a quantum qubit. According to the Paul linear trap, one of the essential traps for confining ions in one dimension, they may be easily handled and controlled in the quantum state. We used MATLAB programs to simulate the factors affecting the confined state and their impact on it after resolving Mathieu's equation and determining the vibrational state of the ion. That consists of superposition cases between the secular monition and the Micromotion. The a and q values in Mathieu's equation are necessary for three-dimensional confinement for the solutions to be simultaneously stable in both directions. The parameter a depends on the Dc voltage, the ion's mass, the Radio frequencies, and the distance between the trap center and the electrodes. The control by a variable voltage provided it. In addition, it illustrates its effect in a specific chain of trapped ions. This study opens the door to understanding the ideal condition through which it ensures the best state of confinement and selecting what is necessary to reach the resonance state for ions transport from the state (4S1/2) to the state (4P1/2). After that, the manipulation of the quantum state begins.
Evaluation Lycopene effect as a monotherapy and add on to Clobetasol on Spleen inflammatory biomarkers and spleen index in IMQ induced psoriasis like inflammation in mice
Authors: Mohammed Samer Shukur , Mustafa Wael Waleed 
Published: March 2023

Abstract
Lycopene is a nutraceutical pigment present in red fruits and vegetables. many researches proved the positive impact of lycopene on many diseases throughout several years especially on inflammation conditions, cardiovascular illness, prostate cancer, and various dermatological disorders. Objective: two different concentrations of topical Lycopene as a monotherapy and as addition therapy to Clobetasol on a mouse induced Psoriasis previously by Imiquimod.
Methods: six groups that contain 8 mice in each group, totally 48 mice were used . Imiquimod was administered to five groups (except first Group , which is controlled group) for six consecutive days to induce psoriasis and further six days during application of tested agents. Group 2 received Petrolatum gel only for 6 consecutive days following six-days Imiquimod induction phase. Groups 3-6 received different materials Clobetasol propionate, 0.125 mg/ml and 0.25 mg/ml of Lycopene, and a combination of 0.05% Clobetasol with 0.25 mg/ml Lycopene, all tested material were applied as an ointment once daily for six days concomitantly with Imiquimod.
Results: Lycopene showed significant decrease on spleen index and was able to restore the level of spleen inflammatory mediators (TNF-α, IL-23, NF-KB and IL-17,) to nearly normal one after utilizing Lycopene 0.25 mg/ml and when had been added to Clobetasol.
Conclusion: Lycopene shows significant spleen normalizing action against Imiquimod-induced psoriasis via its anti-inflammatory action.
Pre-sowing soil carbon dioxide emissions of the following year from the silage maize field irrigated with different levels of wastewater in conventional and direct sowing practices
Authors: Yerli Caner , Sahin Ustun 
Published: March 2023

Abstract
While knowing CO2 emissions during the seasonal period are important, determining residual effect before sowing in the following year can be an available practice in improving wastewater irrigation strategies. Therefore, this study investigated CO2 emission from the silage maize field plots irrigated with wastewater at different levels under conventional and direct sowing in the pre-sowing period after two experimental years by comparing freshwater with full irrigation, and correlated with H2O emission and, soil moisture and temperatures. The results showed that irrigation with wastewater and conventional tillage in the previous two years resulted in higher CO2 emissions in the following period also, and 27 and 11% higher emissions were determined in irrigation with wastewater at 100 and 67% levels than full freshwater irrigation. In irrigation with wastewater at 100% level and direct sowing, soil moisture was found higher, while reduced H2O emission and the soil temperatures at 5 and 10 cm depths. Considering moisture conservation effect of direct sowing, it could be concluded that to reduce on the residual CO2 emission effect of irrigation with wastewater from previous years, deficit irrigation in direct sowing can be recommended practice.
Insulin Resistance Indices and Carotid Intima-media Thickness in Physically
Fit Adults: CHIEF Atherosclerosis Study
Authors: Lin Yen-Po , Hsu Yi-Chiung , Tsai Kun-Zhe , Kwon Younghoon , Lin Gen-Min 
Published: March 2023

Aims:
This study aims to examine the associations between various non-insulin-based insulin
resistance (nIIR) indices and subclinical atherosclerosis assessed by carotid intima-media thickness
(cIMT) in young adults.

Background:
nIIR indices, e.g., serum triglycerides (TG) have been reported with an association with
cIMT in middle- and old-aged adults.

Objective:
We examined the associations of various well-known nIIR indices reported before with
cIMT in young adults.

Methods:
A total of 1,822 young adults free of diabetes in Taiwan were included in 2018-2020. nIIR
indices were assessed by TG concentrations, the TyG index, defined as Ln (TG *fasting glucose/2),
the TG/high-density lipoprotein cholesterol (HDL-C) ratio, defined as TG divided by HDL-C, and
the metabolic score for IR (METS-IR), defined as Ln[(2*fasting glucose)+TG) * body mass index
(BMI)/(Ln(HDL-C))]. Multivariable linear regression analyses with adjustments for age, sex, anthropometrics,
smoking, alcohol consumption, blood pressure, and total cholesterol were used to determine
the associations. For TG only, HDL-C and fasting glucose were additionally adjusted.

Results:
In the overall participants, there was an association between cIMT and TG (β: 0.057, p =
0.04). In subgroup analyses, cIMT was associated with TG (β: 0.127, p = 0.004), the TyG index (β:
0.119, p = 0.01), and TG/HDL-C (β: 0.081, p = 0.03) in the overweight / obese (BMI ≥25 kg/m2),
while not in the normal weight individuals. However, cIMT was correlated with TG (β: 0.086, p =
0.01) and TG/HDL-C (β: 0.077, p = 0.01) in those without hyperuricemia, while not in those with
hyperuricemia. No association between the METS-IR and cIMT in any young adult subgroups was
observed.

Conclusion:
This study highlights that some nIIR indices could be used to assess cIMT in young
adults, particularly for those with obesity and those without hyperuricemia. The TG-based indices
instead of the novel marker, METS-IR, are suggestive as stronger predictors of greater cIMT in young
adults.
Data Provenance in Biomedical Research: Scoping Review
Authors: Johns Marco , Meurers Thierry , Wirth Felix N , Haber Anna C , Müller Armin , Halilovic Mehmed , Balzer Felix , Prasser Fabian 
Published: March 2023

Background
Data provenance refers to the origin, processing, and movement of data. Reliable and precise knowledge about data provenance has great potential to improve reproducibility as well as quality in biomedical research and, therefore, to foster good scientific practice. However, despite the increasing interest on data provenance technologies in the literature and their implementation in other disciplines, these technologies have not yet been widely adopted in biomedical research.

Objective
The aim of this scoping review was to provide a structured overview of the body of knowledge on provenance methods in biomedical research by systematizing articles covering data provenance technologies developed for or used in this application area; describing and comparing the functionalities as well as the design of the provenance technologies used; and identifying gaps in the literature, which could provide opportunities for future research on technologies that could receive more widespread adoption.

Methods
Following a methodological framework for scoping studies and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines, articles were identified by searching the PubMed, IEEE Xplore, and Web of Science databases and subsequently screened for eligibility. We included original articles covering software-based provenance management for scientific research published between 2010 and 2021. A set of data items was defined along the following five axes: publication metadata, application scope, provenance aspects covered, data representation, and functionalities. The data items were extracted from the articles, stored in a charting spreadsheet, and summarized in tables and figures.

Results
We identified 44 original articles published between 2010 and 2021. We found that the solutions described were heterogeneous along all axes. We also identified relationships among motivations for the use of provenance information, feature sets (capture, storage, retrieval, visualization, and analysis), and implementation details such as the data models and technologies used. The important gap that we identified is that only a few publications address the analysis of provenance data or use established provenance standards, such as PROV.

Conclusions
The heterogeneity of provenance methods, models, and implementations found in the literature points to the lack of a unified understanding of provenance concepts for biomedical data. Providing a common framework, a biomedical reference, and benchmarking data sets could foster the development of more comprehensive provenance solutions.
Using Health-Related Social Media to Understand the Experiences of Adults With Lung Cancer in the Era of Immuno-Oncology and Targeted Therapies: Observational Study
Authors: Booth Alison , Manson Stephanie , Halhol Sonia , Merinopoulou Evie , Raluy-Callado Mireia , Hareendran Asha , Knoll Stefanie 
Published: March 2023

Background
The treatment of non–small cell lung cancer (NSCLC) has evolved dramatically with the approval of immuno-oncology (IO) and targeted therapies (TTs). Insights on the patient experience with these therapies and their impacts are lacking. Health-related social media has been increasingly used by patients to share their disease and treatment experiences, thus representing a valuable source of real-world data to understand the patient’s voice and uncover potential unmet needs.

Objective
This study aimed to describe the experiences of patients with NSCLC as reported in discussions posted on lung cancer–specific social media with respect to their disease symptoms and associated impacts.

Methods
Publicly available posts (2010-2019) were extracted from selected lung cancer– or NSCLC-specific websites. Social media users (patients and caregivers posting on these websites) were stratified by metastatic- and adjuvant-eligible subgroups and treatment received using natural language processing (NLP) and machine learning methods. Automated identification of symptoms was conducted using NLP. Qualitative data analysis (QDA) was conducted on random samples of posts mentioning pain-related, fatigue-related, respiratory-related, or infection-related symptoms to capture the patient experience with these and associated impacts.

Results
Overall, 1724 users (50,390 posts) and 574 users (4531 posts) were included in the metastatic group and adjuvant group, respectively. Among users in the metastatic group, pain, discomfort, and fatigue were the most commonly mentioned symptoms (49.7% and 39.6%, respectively), and in the QDA (258 posts from 134 users), the most frequent impacts related to physical impairments, sleep, and eating habits. Among users in the adjuvant group, pain, discomfort, and respiratory symptoms were the most commonly mentioned (44.8% and 23.9%, respectively), and impacts identified in the QDA (154 posts from 92 users) were mostly related to physical functioning.

Conclusions
Findings from this exploratory observational analysis of social media among patients and caregivers informed the lived experience of NSCLC in the era of novel therapies, shedding light on most reported symptoms and their impacts. These findings can be used to inform future research on NSCLC treatment development and patient management.
Problematizações sobre diversidade e diferença e a relação com a racionalidade neoliberal no mercado de trabalho do agronegócio
Authors: Feijó Ana Paula Speck , Ribeiro Paula Regina Costa 
Published: March 2023

O presente trabalho tem, como objetivo, analisar o Programa Diversidade, o qual faz parte de uma indústria internacional do agronegócio, a fim de problematizarmos como a diversidade se tornou um tema presente em diferentes espaços, entre eles no mercado de trabalho, mais especificamente, na indústria. No estudo, estabelecemos algumas conexões com proposições de Foucault, como a problematização, que é a ferramenta analítica utilizada para a construção desse artigo. Realizamos a análise de três entrevistas, com diretores da empresa, sobre o entendimento deles com relação à diversidade e como essa temática chegou até a empresa. Para promover a problematização dessas entrevistas, buscamos, a partir de lentes pós-estruturalistas, teóricos que abordam os conceitos de diversidade e diferença e os relacionam com a racionalidade neoliberal. A análise dos dados empíricos mostrou que os discursos acerca do Programa Diversidade são permeados pela racionalidade neoliberal e, ao mesmo tempo, não garantem a inclusão da diferença, já que a diversidade dialoga com o universal, e a diferença conversa com o único. Também ficou evidenciado que a empresa, ao incluir essa temática como um valor, busca ter, em seu quadro de pessoal, um certo reflexo da sociedade na qual está inserida. Acreditamos que essa pesquisa se configure como potente no sentido de nos fazer entendermos melhor como é compreendida a diversidade no contexto fabril e de que modo é trabalhado esse conceito para a inclusão de sujeitas/os/es no ambiente laboral.
NATIVE-CENTEREDNESS IN THE ENGLISH LANGUAGE TEACHING MATERIALS: A MULTIMODAL CRITICAL DISCOURSE ANALYSIS ON INDONESIAN ELT TEXTBOOKS’ COVER
Authors: Purba Hilarius Raditya Priambada 
Published: March 2023

This is a multimodal critical discourse analysis of three Indonesian English language teaching textbooks. The study focused on the representation of the visuals on the cover to describe English as an International Language paradigm in Indonesia. This study was a qualitative study where the data were presented in the form of a narrative story. The researcher also employed themes to answer the research questions. The result showed that the orientation of English language teaching in Indonesia was native-centeredness where correctness was the focus of the process. Meanwhile, the practice would not prepare the student to have cross-cultural communication where English was used as the Lingua Franca. The result was likely to be in accordance with the latest study on Indonesian teachers’ perspective of the EIL paradigm which showed reluctance.
Do Father Support Programmes Make A Difference? Examination of the Father Involvement Roles
Authors: SÖNMEZ Aslı , KONAKLI Tuğba 
Published: March 2023

Purpose: The purpose of this study is to examine why fathers who participated in the father support programme organised by Mother Child Education Foundation (MCEF) participated in the programme, the change in their views regarding father involvement roles, and their suggestions for the programme.
Design/Methodology/Approach: The research is in the qualitative research model and designed in case study method. The criterion sampling method was used to determine the study group of the research. The sampling of this study consisted of 12 fathers who regularly attended the Father Support Programme conducted in a kindergarten in Derince district of Kocaeli province in the 2019-2020 academic year. In the study the data obtained through a semi-structured interview form were analysed through the content analysis method.
Findings: According to research findings, participants took part in the programme to establish a close relationship, gain proper parental attitudes, and receive emotional support. The participant father views regarding father involvement and the change in their practices were examined in five categories: Interactive togetherness, accessibility, responsibility, empathic approach, and democratic attitude. In line with the study outcomes. The suggestions of the participants were demonstrated at the micro and macro levels. At the micro-level, it was indicated that the parents should attend such support programmes together, and families with different parental attitudes should be reached. At the macro-level, the integration of this school-run organisation into the educational curriculum and its spread through non-governmental organisations and municipalities are included.
Highlights: It was recommended that the father support programmes should be disseminated in schools and supported by the local authorities. For the dissemination of the training activities, studies can be carried out in universities for the prospective teachers to allow them to meet the Father Support Programme and the Ministry of National Education can take steps to support the teachers that are competent in family involvement programmes to apply these activities in their classrooms and schools.