bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutritional Status of Pediatric Patients With Acute Lymphoblastic Leukemia Under Chemotherapy: A Pilot Longitudinal Study
Authors: Kandemir Ibrahim , Anak Sema , Karaman Serap , Yaman Akan , Varkal Muhammet Ali , Devecioglu Omer 
Published: June 2023

Background:
The study investigates the nutritional status in children with acute lymphoblastic leukemia (ALL) during chemotherapy treatment because nourishment is substantial, as much as chemotherapy in children with malignant diseases.

Material and Method:
We enrolled 17 children with ALL (between 1 to 16 year-old, mean age 6.03 ± 4.04 y) from 5 different centers in Istanbul between September 2013 and May 2014. Anthropometric data, prealbumin, B12, and folate levels were assessed, at diagnosis, after the induction phase of chemotherapy, and before maintenance phases of chemotherapy in a longitudinal and prospective study.

Results:
Patients remarkably lost weight at the end of the induction phase (P=0.064) and regained this loss before maintenance chemotherapy (P=0.001). At the end of induction chemotherapy serum prealbumin level (P=0.002), weight for height ratios (P=0.016), weight for age ratios (P=0.019) significantly decreased. From the end of the induction phase to the beginning of maintenance chemotherapy, weight (P=0.001) and weight for age (P=0.017) significantly, and weight for height were remarkably elevated (P=0.076). At the end of the induction phase, serum prealbumin levels were significantly lower (P=0.048) and below laboratory reference values (P=0.009) in children younger than 60 months compared with those older. Serum folate levels increased from the end of the induction phase to the beginning of the maintenance phase (P=0.025). Serum vitamin B12 levels did not alter significantly.

Conclusion:
There is malnutrition risk at the end of the induction phase of the ALL-BFM chemotherapy regimen; therefore, clinicians should follow up on nutrition closely, especially in under 5-year-old patients. However, before the beginning of the maintenance phase, children start to gain weight, and obesity risk occurs. Thus, further studies are needed to evaluate nutritional status during childhood ALL chemotherapy.
Internal Expansion Preconditioning of Recipient Site Increases Fat Graft Retention by Enriching Stem Cell Pool and Inducing Browning in Rats
Authors: He Yufei , Li Jian , Liang Zhuokai , Tang Haojing , Shi Jiaolong , Cai Junrong , Liao Yunjun 
Published: June 2023

Background:
Fat grafting has an unsatisfactory retention rate for breast reconstruction due to poor recipient conditions. The contribution of the recipient site to fat grafts is unknown. In this study, we hypothesize that tissue expansion could improve fat graft retention by preconditioning the recipient fat fad.

Methods:
Over-expansion was achieved using 10 ml cylindrical soft-tissue expanders implanted beneath the left inguinal fat flaps of 16 Sprague-Dawley rats (weighing 250–300 g), whose contralateral parts were implanted with a silicone sheet as control. After 7-days expansion, the implants were removed and both inguinal fat flaps received 1 ml of fat grafts from 8 donor rats. Fluorescent dye-labeled mesenchymal stromal cells (MSCs) were injected into rats and tracked in vivo by fluorescence imaging. Transplanted adipose tissue was harvested at 4 and 10 weeks (n = 8 per time point).

Results:
After 7-days expansion, OCT4+ (p = 0.0002) and Ki67+ (p = 0.0004) positive area were increased with up-regulated expression of CXCL12 in recipient adipose flaps. An increasing number of DiI-positive MSCs were observed in the expanded fat pad. At 10 weeks after fat grafting, retention rate, measured using the Archimedes principle, was much higher in the expanded group than that in the non-expanded group (0.3019 ± 0.0680 vs. 0.1066 ± 0.0402, p = 0.0005). Histologic and transcriptional analyses revealed that angiogenesis was enhanced, and macrophage infiltration was decreased in the expanded group.

Conclusions:
Internal expansion preconditioning increased circulating stem cells into recipient fat pad and contributed to improved fat graft retention.
Incompletely Decellularized Tracheal Matrix Scaffold for Tissue Engineering
Authors: Zhou Yu , Zhang Jianhua , Zang Mengqing 
Published: June 2023

Background:
Dense cartilaginous extracellular matrix makes decellularization and repopulation of tracheal cartilage difficult. However, the dense matrix isolates cartilaginous antigens from the recipient’s immune system. Therefore, allorejection may be avoided by removing antigens from non-cartilaginous tissues. In this study, incompletely decellularized tracheal matrix scaffolds were developed for tracheal tissue engineering.

Methods:
Brown Norway rat tracheae were decellularized with 4% sodium deoxycholate treatment. The cell and antigen removal efficacy, histoarchitecture, surface ultrastructure, glycosaminoglycan and collagen contents, mechanical properties, and chondrocyte viability of the scaffold were evaluated in vitro. Brown Norway rat tracheal matrix scaffolds (n = 6) were implanted subcutaneously into Lewis rats and observed for four weeks. Brown Norway rat tracheae (n = 6) and Lewis rat scaffolds (n = 6) were implanted as controls. Histological analysis of macrophage and lymphocyte infiltration was performed.

Results:
One decellularization cycle removed all cells and antigens from non-cartilaginous tissue. Incomplete decellularization preserved the structural integrity of the tracheal matrix and chondrocyte viability. Except for 31% glycosaminoglycan loss, the scaffold had comparable collagen content and tensile and compressive mechanical properties to those of the native trachea. The allogeneic scaffold showed remarkably reduced CD68+, CD8+, and CD4+ cell infiltration compared with the allografts and demonstrated similar cell infiltration to the syngeneic scaffold. It also maintained the 3D tracheal structure and cartilage viability in vivo.

Conclusions:
Incompletely decellularized trachea did not induce immunorejection and maintained the integrity and viability of cartilage in vivo. Tracheal decellularization and repopulation can be significantly simplified for urgent tracheal replacement.

Clinical Relevance Statement:
The present study describes the development of an incomplete decellularization protocol that creates a decellularized matrix scaffold for tracheal tissue engineering, aiming to provide preliminary data that this method may generate suitable tracheal scaffolds for use in tracheal replacement.
Phylomitogenomics bolsters the high-level classification of Demospongiae (phylum Porifera)
Authors: Lavrov Dennis V. , Diaz Cristina , Maldonado Manuel , Morrow Christine , Perez Thierry , Pomponi Shirley A. , Thucker Robert W. 
Published: June 2023

AbstractClass Demospongiae – the largest in the phylum Porifera (Sponges) – encompasses nearly 8,000 accepted species in three subclasses: Keratosa, Verongimorpha, and Heteroscleromorpha. Subclass Heteroscleromorpha contains ∼90% of demosponge species and is subdivided into 17 orders. The higher level classification of demosponges underwent major revision as the result of nearly three decades of molecular studies. However, because most of the previous molecular work only utilized partial data from a small number of nuclear and mitochondrial (mt) genes, this classification scheme needs to be tested by larger datasets. Here we compiled a mt dataset for 136 demosponge species – including 64 complete or nearly complete and six partial mt-genome sequences determined or assembled for this study – and used it to test phylogenetic relationships among Demospongiae in general and Heteroscleromorpha in particular. We also investigated the phylogenetic position ofMyceliospongia araneosa– a highly unusual demosponge without spicules and spongin fibers, currently classified as Demospongiaeincertae sedis, for which molecular data were not available. Our results support the previously inferred sister-group relationship between Heteroscleromorpha and Keratosa + Verongimorpha and suggest five main clades within Heteroscleromorpha: Clade C0 composed of order Haplosclerida; Clade C1 composed of Scopalinida, Sphaerocladina, and Spongillida; Clade C2 composed of Axinellida, Biemnida, Bubarida; Clade C3 composed of Tetractinellida; and Clade C4 composed of Agelasida, Clionaida, Desmacellida, Merliida, Suberitida, Poecilosclerida, Polymastiida, and Tethyida. The inferred relationships among these clades were (C0(C1(C2(C3+C4)))). Analysis of molecular data fromM. araneosaplaced it in the C3 clade as a sister taxon to the highly skeletonized tetractinellidsMicrosclerodermasp. andLeiodermatiumsp. Molecular clock analysis dated divergences among the major clades in Heteroscleromorpha from the Cambrian to the Early Silurian, the origins of most heteroscleromorph orders in the middle Paleozoic, and the most basal splits within these orders around the Paleozoic to Mesozoic transition. Overall, the results of this study are mostly congruent with the accepted classification of Heteroscleromorpha, but add temporal perspective and new resolution to phylogenetic relationships within this subclass.
The Non-Mevalonate Pathway Requires a Delicate Balance of Intermediates to Maximize Terpene Production
Authors: Raghavan Indu , Wang Zhen Q. 
Published: June 2023

AbstractTerpenes are valuable industrial chemicals whose demands are increasingly being met by bioengineering microbes such asE. coli. Although the bioengineering efforts commonly involve installing the mevalonate (MVA) pathway inE. colifor terpene production, the less studied methylerythritol phosphate (MEP) pathway is a more attractive target due to its higher energy efficiency and theoretical yield, despite its tight regulation. In this study, we integrated an additional copy of the entire MEP pathway into theE. coligenome for stable, marker-free terpene production. The genomically integrated strain produced more monoterpene geraniol than a plasmid-based system. The pathway genes’ transcription was modulated using different promoters to produce geraniol as the reporter of the pathway flux. Pathway genes, includingdxs, idi, andispDF, expressed from a medium-strength promoter, led to the highest geraniol production. Quantifying the MEP pathway intermediates revealed that the highest geraniol producers had high levels of isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), but moderate levels of the pathway intermediates upstream of these two building blocks. A principal component analysis demonstrated that 1-deoxy-D-xylulose 5-phosphate (DXP), the product of the first enzyme of the pathway, was critical for determining the geraniol titer, whereas MEP, the product of DXP reductoisomerase (Dxr or IspC), was the least essential. This work shows that an intricate balance of the MEP pathway intermediates determines the terpene yield in engineeredE. coli. The genetically stable and intermediate-balanced strains created in this study will serve as a chassis for producing various terpenes.Key PointsGenome-integrated MEP pathway afforded higher strain stabilityGenome-integrated MEP pathway produced more terpene than the plasmid-based systemHigh monoterpene production requires a fine balance of MEP pathway intermediates
The Emergence of Circadian Timekeeping in the Intestine
Authors: Parasram Kathyani , Zuccato Amy , Shin Minjeong , Willms Reegan , Deveale Brian , Foley Edan , Karpowicz Phillip 
Published: June 2023

AbstractThe circadian clock is a molecular timekeeper, present from cyanobacteria to mammals, that coordinates internal physiology with the external environment. The clock has a 24-hour period however development proceeds with its own timing, raising the question of how these interact. Using the intestine ofDrosophila melanogasteras a model for organ development, we track how and when the circadian clock emerges in specific cell types. We find that the circadian clock begins abruptly in the adult intestine and gradually synchronizes to the environment after intestinal development is complete. This delayed start occurs because individual cells at earlier stages lack the complete circadian clock gene network. As the intestine develops, the circadian clock is first consolidated in intestinal stem cells with changes in ecdysone and Bursicon hormone signalling influencing the transcriptional activity of Clk/cyc to drive the expression oftim,Pdp1,andvri. In the mature intestine, stem cell lineage commitment transiently disrupts clock activity in differentiating progeny, mirroring early developmental clock-less transitions. Our data show that clock function and differentiation are incompatible and provide a paradigm for studying circadian clocks in development and stem cell lineages.
Decreased inter-hemispheric connectivity predicts a coherent retrieval of auditory symbolic material in a laboratory model of cultural transmission
Authors: Bonetti Leonardo , Vænggård Anna Kildall , Iorio Claudia , Vuust Peter , Lumaca Massimo 
Published: June 2023

AbstractInvestigating the transmission of information between individuals is essential to understand how human culture evolved. Coherent information transmission (i.e., transmission without significant modifications or loss of fidelity) helps preserving cultural traits and traditions over time, while innovation may lead to new cultural variants. Although much research has focused on the cognitive mechanisms underlying cultural transmission, little is known on the brain underpinnings of coherent transmission of information. To address this gap, we combined a laboratory model of cultural transmission, the signalling games, with structural (from high-resolution diffusion imaging) and functional connectivity (from resting-state functional magnetic resonance imaging [fMRI]). We found that individuals who exhibited more coherence in the transmission of the information were characterized by lower levels of both structural and functional inter-hemispheric connectivity. Specifically, higher coherence negatively correlated with the strength of bilateral structural connections between frontal and subcortical, insular and temporal brain regions. Similarly, we observed increased inter-hemispheric functional connectivity between inferior frontal brain regions derived from structural connectivity analysis in individuals who exhibited lower transmission coherence. Our results suggest that inter-hemispheric connections may bwe detrimental for preserving coherence in information transmission, while a certain degree of lateralization in the brain may be required.
Convergence in working conditions
Authors: Antón José-Ignacio , Grande Rafael , Muñoz de Bustillo Rafael 
Published: June 2023

Purpose
This paper aims to explore the existence of convergence in non-monetary working conditions in Europe resorting to widely used definitions of this phenomenon and composite indexes of job quality.

Design/methodology/approach
The analysis relies on composite indexes, widely used in previous literature, for 207 regions in six different areas of job quality drawing on the microdata of the European Working Conditions Survey from 1995 to 2015. This study assesses the occurrence of convergence both in terms of dispersion of job quality outcomes (sigma-convergence) and, especially, regarding the existence of a catch-up process (beta-convergence).

Findings
This study finds evidence of both types of convergences in all the domains, with the exception of skills and discretion and prospects dimensions according to the sigma-convergence approach. The results do not suggest substantial differences between the 15 European Union countries before the 2004 enlargement and the new Member States and are robust to a wide range of changes in the sample and different econometric specifications.

Originality/value
Tot he best of the authors’ knowledge, this paper represents the first rigorous and systematic attempt of addressing the existence of convergence in non-monetary working conditions, applying formal and widely accepted definitions of this phenomenon. It contributes to our knowledge on this topic providing strong evidence of convergence in job quality. Those results can be of interest for scholars in Economics and other Social Sciences.
The interaction of organizational politics and political skill on employees' exposure to workplace cyberbullying: the conservation of resources theory perspective
Authors: Charoensukmongkol Peerayuth 
Published: June 2023

PurposeConsidering the detrimental impact of workplace cyberbullying on employees and organizations, it is necessary to understand factors that potentially induce employees to engage in cyberbullying and to recognize personal characteristics that may help employees mitigate its impact. This research applies the conservation of resources (COR) theory to investigate the effect of organizational politics and political skill on employees' exposure to workplace cyberbullying as well as to analyze the subsequent impact on emotional exhaustion. Moreover, the interaction effect of political skill and organizational politics on employees' exposure to workplace cyberbullying is analyzed.Design/methodology/approachThe total of 358 complete questionnaires were obtained from one medium-sized public university in Thailand. The partial least squares structural equation modeling (PLS-SEM) was used to analyze the data.FindingsThe analysis supports the positive association between organizational politics and employees' exposure to workplace cyberbullying. Employees' exposure to workplace cyberbullying also has a positive association with emotional exhaustion. On the other hand, the analysis showed that political skill has a negative association with employees' exposure to workplace cyberbullying. The result from the moderating effect analysis further shows that political skill also reduces the impact of organizational politics on employees' exposure to workplace cyberbullying.Originality/valueThe incorporation of the COR theory provides theoretical insight into how political skill of employees can buffer the impact of organizational politics on exposure to workplace cyberbullying. It advances the knowledge found in previous research that lacked solid theory to explain the interaction between organizational politics and political skill of employees in the area of workplace cyberbullying.
Understanding young Chinese consumers' preferences for foreign clothing brands: a behavioural approach
Authors: May Daniel Esteban , Arancibia Sara , Wang Calvin , Hill Nigel , Behrendt Karl 
Published: June 2023

PurposeThis research explores the purchasing behavioural drivers of young Chinese consumers purchasing foreign clothing brands. The aim is to include a range of drivers identified by different investigations into a single approach, to determine direct and indirect channels by which these drivers influence purchasing behaviour, and their relative importance in quantitative terms.Design/methodology/approachThe methodology is based on an extended version of the theory of planned behaviour that considers hypotheses based on a number of studies revised in the literature review. This theoretical framework was used as the basis for a questionnaire applied to a sample of 362 young Chinese consumers. A Partial Least Squares Structural Equation Modelling approach was used to analyse the collected data.FindingsThe results revealed three main channels influencing purchasing behaviour which were shown to share the same root, corresponding to the influences of the social network young consumers belong to. This result suggests that social norms have a key role in explaining young consumers' purchasing behaviour through its impact on their needs for status and social recognition, their attitudes towards foreign cultures and foreign brands, and their beliefs regarding the attributes of foreign clothing.Practical implicationsThe work therefore provides companies operating in the foreign clothing market the confidence to devise business strategies that focus on the channel demonstrating the highest influencing power. A strategy likely to have the highest influencing power is one that uses celebrities to promote the reputation of products and reinforce the messages associated with status and social recognition. Reinforcement of these strategies could include secondary strategies linked to the other channels such as the one related to the adoption of foreign cultural symbolism.Originality/valueIn contrast to the majority of related studies, this investigation also explores indirect channels or paths by which a behavioural driver affects the behaviour of young Chinese consumers. In fact, this investigation not only simultaneously identified the different paths influencing young Chinese consumers purchasing behaviour but also quantitatively identified their relative importance.
Self-initiated expatriation: a career perspective through a social chronology lens
Authors: Gunz Hugh 
Published: June 2023

PurposeThis is a conceptual paper, intended to link the constructs self-initiated expatriation (SIE) and career. The author suggests that regarding SIE as an episode in a career allows one to use ideas from the careers literature to suggest novel areas for research on SIE, thereby contributing to the SIE literature. The author employs a particular perspective on career – the social chronology framework (SCF) – to show how the framework can suggest these novel areas of research on self-initiated expatriation. The SCF views careers through three perspectives related to the space within which the career takes place, the career actor who “has” the career, and the time over which the career plays out. By looking at SIEs through each of these perspectives in turn a number of research questions are suggested that have the potential to enrich the SIE literature.Design/methodology/approachThe paper first considers the construct of career and shows how self-initiated expatriation fits with it. Next, it introduces the SCF, and finally shows how it can be used to derive ideas for research on self-initiated expatriation.FindingsThere are none, given that this is a conceptual paper.Research limitations/implicationsThe paper suggests future directions for research on SIEs.Originality/valueThe author believes that the application of the SCF to the study of self-initiated expatriation is novel.
Implementing and performing sustainability strategies at campus operations: the case of Instituto Federal de Santa Catarina
Authors: Reisch Osni Cristiano , Lima Josiane , Soares Thiago Coelho , Tutida Alessandra Yula , Mazon Gisele , Andrade de Lima Maurício , Montenegro de Lima Carlos Rogério , Dutra Ana Regina Aguiar , Guerra José Baltazar Salgueirinho Osório de Andrade 
Published: June 2023

Purpose
This study aims to analyze the alignment between sustainable performance and sustainability planning in higher education, proposing a strategic map that integrates planning with the implementation of performance actions and sustainable performance on campuses.

Design/methodology/approach
The literature review development addresses sustainability in higher education institutions (HEIs). Data collection took place in two ways, documentary, through the analysis of documents and through an open interview, guided by a script with 13 questions. For data interpretation, the content analysis technique was applied.

Findings
To achieve the objective of this work, this study proposed a sustainable performance strategic map for better management of the university’s green strategies, based on three dimensions: internal processes, educational and sustainable performance.

Originality/value
This study’s main contribution was to propose a sustainable performance strategic map as a strategic management system aimed at HEIs to accelerate the promotion of sustainability in these organizations.