bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defining the limits of the anterior wall of the cavernous sinus through an endoscopic view: Cadaveric anatomical study
Authors: Sangrador-Deitos Marcos V , Guinto-Nishimura Gerardo Y , Rodriguez-Hernandez Luis A , Campero Alvaro 
Published: July 2023

Background:
The anterior wall of the cavernous sinus (CS) represents an important landmark for endoscopic surgery that although mentioned before, no precise anatomical boundaries have been described. We describe the anatomical landmarks that delimit the anterior wall of the CS, emphasizing its importance as a reference for accessing the CS through endoscopic approaches.

Methods:
Six adult cadaveric heads fixed with formaldehyde and injected with colored silicone were studied. In all the heads, an endonasal endoscopic approach to the sellar and parasellar regions was performed and the anatomy of the anterior wall of the CS was studied.

Results:
Four consistent anatomical landmarks that mark the limits of the anterior wall of the CS were found in all the specimens: anterosuperiorly, the lateral opticocarotid recess; posterosuperiorly, the medial opticocarotid recess; anteroinferiorly, the inferior part of the maxillary strut; and posteroinferiorly, the superolateral angle of the clival recess.

Conclusion:
It is of paramount importance to recognize the anatomical landmarks that define the limits of the anterior wall of the CS to achieve a safe access to this so complex region.
FACTORS DETERMINING PSYCHOLOGICAL HEALTH PSYCHOLOGY STUDENTS
Authors: Шакурова А.А. 
Published: July 2023

Исследована возможность использования критериев «удовлетворенность жизнью», «субъективное благополучие» и «психологическое благополучие» для характеристики психологического здоровья студентов. Выявлено, что психологическое здоровье определяется психологическим состоянием внутреннего благополучия личности, обусловленное влиянием индивидуально-личностных особенностей человека, степенью удовлетворенности его потребностей и реализацией жизненных планов, и такие характеристики, как «удовлетворенность жизнью», «субъективное благополучие» и «психологическое благополучие» могут являться факторами, определяющими психологическое здоровье человека
Examines the possibility of using the criteria «life satisfaction», «subjective well-being» and «psychological well-being» to characterize the psychological health of students. This study was conducted using Spearman's rank correlation coefficient on a sample of 87 psychology students of the Faculty of Psychology and Special Education. It is revealed that psychological health is determined by the psychological state of the inner well-being of the individual, due to the influence of individual and personal characteristics of a person, the degree of satisfaction with his needs and the implementation of life plans, and characteristics such as «life satisfaction», «subjective well-being» and «psychological well-being» can be factors determining the psychological health of a person.
Мемлекеттік саясат жүйесіндегі әлеуметтік бақылауды дамытудың теориялық негіздері
Authors: Бокаев Б.Н. , Есенгельдина А.C. , Есиркепова А.М. , Кошербаев Д.Б. , Мусатаева А.А. 
Published: July 2023

Мақсаты: Мақала мемлекеттің саяси жүйесінде әлеуметтік бақылаудың даму ерекшеліктеріне арналған. Мақала авторлары әлеуметтік бақылау органдары мен мемлекеттік органдардың өзара әрекеттесуіне мүмкіндік беретін саясатты әзірлеу және іске асыру үдерісінің әртүрлі кезеңдерін зерттеген.
Әдісі: Зерттеудің жалпы ғылыми әдістері мен салыстырмалы талдаудың көмегімен саясатты жоспарлау және жүзеге асыру, саяси бастаманың заңдылығын, сапасын, түсінігін және ұзақ мерзімді қолданылуын арттыру үшін әлеуметтік бақылауды қолдану қажеттілігі туралы қорытындылар жасалған.
Қорытынды: Мақалада мемлекеттік саясат жүйесіндегі әлеуметтік бақылау институттарының субъективтілігі туралы мәселені шешуге баса назар аударылады: оларды сәйкестендіру, ынтымақтастық нысандары, функцияларды, жұмыс қағидаттары, тиімділік талаптары мен әлеуетін сипаттау.
Тұжырымдама: Әлеуметтік бақылау заңдарға сәйкес мемлекеттік саясатты іске асыру мақсатында жүзеге асырылады. Мемлекеттік бюджеттен қаржыландырылатын барлық субъектілер әлеуметтік бақылау объектісі болып табылады. Әлеуметтік бақылау логикасы азамат пен мемлекет арасында делдалдық институттар құруға негізделген. Мемлекеттік саясат жүйесін одан әрі жетілдіру үшін әлеуметтік бақылау институттарын цифрландыру келешектерін және осы қызметтің тұтастай алғанда мемлекеттік басқару жүйесінің жұмыс істеу тиімділігіне әлеуетті әсерін зерделеу қажет.
“The working poor” phenomenon: notion, regional characteristics
Authors: Khussainova Zh.S. , Yeskendir N.N. , Kοrchevskaya L.A. , Gordeyeva Y.A. 
Published: July 2023

Object: to focus on the concept, regional features of the phenomenon of “the working poor” in the Republic of Kazakhstan, to determine the share of working poor based on the latest statistical materials. Methods: statistical analysis, comparative analysis and table construction.
Findings: The research results are based on the main results and conclusions: 1. despite the high importance of the issue of economic poverty and attempts to evaluate it empirically, there are different approaches to the definition of “working poor”. 2. a method of assessing labor income based on the base of mandatory pension contributions of it will allow to cover about 56.2% of employed in the local economy. Taking into account this approach to the analysis, in the Republic of Kazakhstan, “working poor” can be defined as employees who work in the official sector of the economy and transfer tax payments to the budget from income from labor activity within 2 ETS. At the same time, their estimated share in the Kazakhstani labor market is about 40%.
Conclusions: the studies have shown that in the regions of the Republic it is necessary to introduce correction factors, addressing various reasons for differentiating labor incomes based on the specifics of the labor market and the living standard of the population.
Prediction of Shear Wave velocity for carbonate rocks
Authors: Al-Kattan Wafa M. 
Published: July 2023

In many oil fields only the BHC logs (borehole compensated sonic tool) are available to provide interval transit time (Δtp), the reciprocal of compressional wave velocity VP.
To calculate the rock elastic or inelastic properties, to detect gas-bearing formations, the shear wave velocity VS is needed. Also VS is useful in fluid identification and matrix mineral identification.
Because of the lack of wells with shear wave velocity data, so many empirical models have been developed to predict the shear wave velocity from compressional wave velocity. Some are mathematical models others used the multiple regression method and neural network technique.
In this study a number of empirical models were considered to predict VS from VP. The models had been correlated and a general equation, based on statistical method, was established for carbonate rocks.
The proposed equation, then, was examined using log data and good results observed.
Enhancing the Lifting Capacity of Drilling Fluids in Vertical Oil Wells
Authors: Assi Amel habeeb 
Published: July 2023

Of the many functions that are performed by the drilling fluid, the most important is to transport cuttings from the bit up the annulus to the surface. Various drilling fluid have been widely used in the oil industry to improve lifting capacity. In this study, three mud type have been used which they are, oil base mud, X-anthan polymer and a mixture of CMC and bentonite ,by using Carrying Capacity Index calculation (CCI) , the Xanthan gave good values of CCI than other studied drilling fluid. By using Sifferman chart and field data from well in south of Iraq and API equation to find cutting concentration in the annulus, The results showed that the used of thick mud increase the lifting capacity and decrease volumetric drill cuttings in the annulus but the using thin mud lead to decrease lifting capacity and increase volumetric drill cuttings in the annulus .The results show that the mud viscosity and flow rate have important role in hole cleaning. Also, the effect of annulus velocity and flow pattern on cutting transport ratio is studied by using field data. The effect of cutting size and OD of drill pipe is also studied. Cutting size is one of the parameters that influence the hole cleaning; large size cutting makes the hole cleaning more difficult. The reducing of annular size of hole by increasing the OD of drill pipe lead to increasing the annular velocity.
Teaching Data Joins: A Conceptual Approach Using SQL, Alteryx, and Tableau
Authors: Li Jie , Lee Lorraine 
Published: July 2023

Abstract
The many ways of joining data can be confusing for beginning, or even intermediate, data analytics students. Several accounting information system textbooks cover SQL and joins, but few supplemental resources exist that can reinforce and clarify join concepts. In this paper, we use a multi-tool approach in a three-part assignment for teaching data joins using three different software tools. We use four different join types (INNER JOIN, LEFT OUTER JOIN, RIGHT OUTER JOIN, and FULL OUTER JOIN) in Microsoft Access, Alteryx, and Tableau. We further demonstrate how the Tableau data model, using separate logical and physical layers, implements the various join types depending on the data needs of a particular visualization. Overall, thus three-part assignment can help students develop a comprehensive understanding of joins and how to implement them in widely-used software tools. The assignment also gives students practice in selecting, using, and validating joins in data analytics.
Biocompatibility and inflammatory response of silver tungstate, silver molybdate, and silver vanadate microcrystals
Authors: Pimentel Bruna Natália Alves da Silva , De Annunzio Sarah Raquel , Assis Marcelo , Barbugli Paula Aboud , Longo Elson , Vergani Carlos Eduardo 
Published: July 2023

Silver tungstate (α-Ag2WO4), silver molybdate (β-Ag2MoO4), and silver vanadate (α-AgVO3) microcrystals have shown interesting antimicrobial properties. However, their biocompatibility is not yet fully understood. Cytotoxicity and the inflammatory response of silver-containing microcrystals were analyzed in THP-1 and THP-1 differentiated as macrophage-like cells, with the alamarBlue™ assay, flow cytometry, confocal microscopy, and ELISA. The present investigation also evaluated redox signaling and the production of cytokines (TNFα, IL-1β, IL-6, and IL-8) and matrix metalloproteinases (MMP-8 and -9). The results showed that α-AgVO3 (3.9 μg/mL) did not affect cell viability (p &gt; 0.05). α-Ag2WO4 (7.81 μg/mL), β-Ag2MoO4 (15.62 μg/mL), and α-AgVO3 (15.62 μg/mL) slightly decreased cell viability (p ≤ 0.003). All silver-containing microcrystals induced the production of O2− and this effect was mitigated by Reactive Oxygen Species (ROS) scavenger and N-acetylcysteine (NAC). TNFα, IL-6 and IL-1β were not detected in THP-1 cells, while their production was either lower (p ≤ 0.0321) or similar to the control group (p ≥ 0.1048) for macrophage-like cells. The production of IL-8 by both cellular phenotypes was similar to the control group (p ≥ 0.3570). The release of MMP-8 was not detected in any condition in THP-1 cells. Although MMP-9 was released by THP-1 cells exposed to α-AgVO3 (3.9 μg/mL), no significant difference was found with control (p = 0.7). Regarding macrophage-like cells, the release of MMP-8 and -9 decreased in the presence of all microcrystals (p ≤ 0.010). Overall, the present work shows a promising biocompatibility profile of, α-Ag2WO4, β-Ag2MoO4, and α-AgVO3 microcrystals.
Identification and validation of a novel HOX-related classifier signature for predicting prognosis and immune microenvironment in pediatric gliomas
Authors: Zhang Jiao , Zhang Xueguang , Su Junyan , Zhang Jiali , Liu Siyao , Han Li , Liu Mengyuan , Sun Dawei 
Published: July 2023

Background: Pediatric gliomas (PGs) are highly aggressive and predominantly occur in young children. In pediatric gliomas, abnormal expression of Homeobox (HOX) family genes (HFGs) has been observed and is associated with the development and progression of the disease. Studies have found that overexpression or underexpression of certain HOX genes is linked to the occurrence and prognosis of gliomas. This aberrant expression may contribute to the dysregulation of important pathological processes such as cell proliferation, differentiation, and metastasis. This study aimed to propose a novel HOX-related signature to predict patients’ prognosis and immune infiltrate characteristics in PGs.Methods: The data of PGs obtained from publicly available databases were utilized to reveal the relationship among abnormal expression of HOX family genes (HFGs), prognosis, tumor immune infiltration, clinical features, and genomic features in PGs. The HFGs were utilized to identify heterogeneous subtypes using consensus clustering. Then random forest-supervised classification algorithm and nearest shrunken centroid algorithm were performed to develop a prognostic signature in the training set. Finally, the signature was validated in an internal testing set and an external independent cohort.Results: Firstly, we identified HFGs significantly differentially expressed in PGs compared to normal tissues. The individuals with PGs were then divided into two heterogeneous subtypes (HOX-SI and HOX-SII) based on HFGs expression profiles. HOX-SII showed higher total mutation counts, lower immune infiltration, and worse prognosis than HOX-SI. Then, we constructed a HOX-related gene signature (including HOXA6, HOXC4, HOXC5, HOXC6, and HOXA-AS3) based on the cluster for subtype prediction utilizing random forest supervised classification and nearest shrunken centroid algorithm. The signature was revealed to be an independent prognostic factor for patients with PGs by multivariable Cox regression analysis.Conclusion: Our study provides a novel method for the prognosis classification of PGs. The findings also suggest that the HOX-related signature is a new biomarker for the diagnosis and prognosis of patients with PGs, allowing for more accurate survival prediction.
The characteristic of atmospheric particulate matter and the influence factors in Xiamen for air quality management
Authors: Lin Jiali , Lin Ying , Lin Shuangyi , Dong Jiaying 
Published: July 2023

Urbanization can drive economic growth, but it may harm the quality of the urban environment if improper actions are performed. Environmental issues resulting from urbanization can negatively impact the health of city dwellers. Therefore, studying air pollutants is crucial to urban development. In this study, we focus on Xiamen and examine the distribution patterns of urban air pollutants over an extended period of time. The goal is to enhance Xiamen’s air quality and bridge the research gap in long-term air quality studies specific to Xiamen. Based on monitoring data from 2014 to 2021 spanning 8 years, this study analyzed the trends in atmospheric particulate matter (PM: PM10, PM2.5) and their relationship with meteorological factors (such as wind speed: WS, temperature: T, dew point temperature: DPT, height of the cloud ceiling: HCC) and the concentrations of other pollutants (SO2, NO2, CO, and O3). The results indicated that (1) The high air quality in Xiamen with the lowest PM values observed during summer and the highest during winter; NO2 and SO2 concentrations showed similar trends to PM, while O3 and CO concentrations varied differently. (2) In general, the maximum daily PM concentration was observed in the evening and early morning, while the lowest value appeared at noon. The concentrations of PMs were positively correlated with other pollutants, while T, WS, HCC (cloud cover of more than 70%), and DPT were negatively correlated with PM concentrations. (3) There exists a relationship between concentrations of atmospheric particulate matter, atmospheric pollutants, and meteorological factors. The wind direction had varying effects on PM concentration, with PM2.5 and PM10 concentrations showing consistent trends and higher concentrations of PMs observed when winds blew from the west, southeast, and northeast. This study also provides a summary of strategies for addressing different air pollutant distribution characteristics. The purpose of this study is to analyze the distribution patterns of air pollutants in Xiamen and provide valuable insights for improving the city’s air quality.
Comprehensive analysis and immune landscape of chemokines- and chemokine receptors-based signature in hepatocellular carcinoma
Authors: Zhang Ze , Mao Mingsong , Wang Fangzhou , Zhang Yao , Shi Jihang , Chang Lei , Wu Xiaolin , Zhang Zhenpeng , Xu Ping , Lu Shichun 
Published: July 2023

BackgroundDespite encouraging results from immunotherapy combined with targeted therapy for hepatocellular carcinoma (HCC), the prognosis remains poor. Chemokines and their receptors are an essential component in the development of HCC, but their significance in HCC have not yet been fully elucidated. We aimed to establish chemokine-related prognostic signature and investigate the association between the genes and tumor immune microenvironment (TIME).Methods342 HCC patients have screened from the TCGA cohort. A prognostic signature was developed using least absolute shrinkage and selection operator regression and Cox proportional risk regression analysis. External validation was performed using the LIHC-JP cohort deployed from the ICGC database. Single-cell RNA sequencing (scRNA-seq) data from the GEO database. Two nomograms were developed to estimate the outcome of HCC patients. RT-qPCR was used to validate the differences in the expression of genes contained in the signature.ResultsThe prognostic signature containing two chemokines-(CCL14, CCL20) and one chemokine receptor-(CCR3) was successfully established. The HCC patients were stratified into high- and low-risk groups according to their median risk scores. We found that patients in the low-risk group had better outcomes than those in the high-risk group. The results of univariate and multivariate Cox regression analyses suggested that this prognostic signature could be considered an independent risk factor for the outcome of HCC patients. We discovered significant differences in the infiltration of various immune cell subtypes, tumor mutation burden, biological pathways, the expression of immune activation or suppression genes, and the sensitivity of different groups to chemotherapy agents and small molecule-targeted drugs in the high- and low-risk groups. Subsequently, single-cell analysis results showed that the higher expression of CCL20 was associated with HCC metastasis. The RT-qPCR results demonstrated remarkable discrepancies in the expression of CCL14, CCL20, and CCR3 between HCC and its paired adjacent non-tumor tissues.ConclusionIn this study, a novel prognostic biomarker explored in depth the association between the prognostic model and TIME was developed and verified. These results may be applied in the future to improve the efficacy of immunotherapy or targeted therapy for HCC.
Di(2-ethylhexyl) phthalate mediates IL-33 production via aryl hydrocarbon receptor and is associated with childhood allergy development
Authors: Tsai Mei-Lan , Hsu Shih-Hsien , Wang Li-Ting , Liao Wei-Ting , Lin Yi-Ching , Kuo Chang-Hung , Hsu Ya-Ling , Feng Ming-Chu , Kuo Fu-Chen , Hung Chih-Hsing 
Published: July 2023

BackgroundFew studies assess cord blood biomarkers to predict prenatal exposure to di(2-ethylhexyl) phthalate (DEHP) on the development of allergic diseases later in childhood. IL-33 has been indicated to play an important role in allergic diseases. We evaluated the association of prenatal DEHP exposure and IL-33 in cord blood on the development of allergic diseases. We also investigated the mechanism of DEHP in human lung epithelial cells and asthma animal models.Methods66 pregnant women were recruited, and their children followed when they were aged 3 years. Maternal urinary DEHP metabolites were determined using liquid chromatography-electrospray-ionization-tandem mass spectrometry. The effect of DEHP on IL-33 production was investigated in human lung epithelial cells and club cell-specific aryl hydrocarbon receptor (AhR) deficiency mice. ELISA and RT-PCR, respectively, measured the IL-33 cytokine concentration and mRNA expression.ResultsThe concentrations of maternal urinary DEHP metabolites and serum IL-33 in cord blood with childhood allergy were significantly higher than those in the non-childhood allergy group. DEHP and MEHP could induce IL-33 production and reverse by AhR antagonist and flavonoids in vitro. Enhanced ovalbumin-induced IL-4 and IL-33 production in bronchoalveolar lavage fluid (BALF) by DEHP exposure and suppressed in club cell-specific AhR null mice. Kaempferol has significantly reversed the DEHP effect in the asthma animal model.ConclusionsCord blood IL-33 level was correlated to childhood allergy and associated with maternal DEHP exposure. IL-33 might be a potential target to assess the development of DEHP-related childhood allergic disease. Flavonoids might be the natural antidotes for DEHP.
Combining convolutional attention mechanism and residual deformable Transformer for infarct segmentation from CT scans of acute ischemic stroke patients
Authors: Xu Zhixiang , Ding Changsong 
Published: July 2023

BackgroundSegmentation and evaluation of infarcts on medical images are essential for diagnosis and prognosis of acute ischemic stroke (AIS). Computed tomography (CT) is the first-choice examination for patients with AIS.MethodsTo accurately segment infarcts from the CT images of patients with AIS, we proposed an automated segmentation method combining the convolutional attention mechanism and residual Deformable Transformer in this article. The method used the encoder-decoder structure, where the encoders were employed for downsampling to obtain the feature of the images and the decoder was used for upsampling and segmentation. In addition, we further applied the convolutional attention mechanism and residual network structure to improve the effectiveness of feature extraction. Our code is available at: https://github.com/XZhiXiang/AIS-segmentation/tree/master.ResultsThe proposed method was assessed on a public dataset containing 397 non-contrast CT (NCCT) images of AIS patients (AISD dataset). The symptom onset to CT time was less than 24 h. The experimental results illustrate that this work had a Dice coefficient (DC) of 58.66% for AIS infarct segmentation, which outperforms several existing methods. Furthermore, volumetric analysis of infarcts indicated a strong correlation (Pearson correlation coefficient = 0.948) between the AIS infarct volume obtained by the proposed method and manual segmentation.ConclusionThe strong correlation between the infarct segmentation obtained via our method and the ground truth allows us to conclude that our method could accurately segment infarcts from NCCT images.