bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manajemen Hipertensi menggunakan Pendekatan Kearifan Lokal di Desa Golowoi Kabupaten Manggarai, NTT
Authors: Tundung Leonardus , Jerin Yoseph , Nadun Yeremias Defrian , Juju Selviana 
Published: January 2023

ABSTRAK Hipertensi masih menjadi penyebab utama kematian pada masyarakat dunia dan masih menjadi tantangan pemerintah pusat maupun daerah di Indonesia dalam berupaya memberikan pemahaman kepada masyarakat akan pentingnya mengetahui faktor resiko penyebab penyakit ini. Faktor resiko penyebab hipertensi adalah konsumsi kopi, merokok dan konsumsi alkohol, dimana ketiganya merupakan pola kebiasaan yang erat dengan masyakarat Manggarai. Sebagai kabupaten yang kental dengan upacara serta kebiasaan adat, kedukaan, perkumpulan, maka merokok dan konsumsi alkohol menjadi semakin sering dilakukan. Telah banyak upaya yang dilakukan tenaga Kesehatan salah satunya dengan memberikan Pendidikan Kesehatan, namun kasus hipertensi masih sangat tinggi, karena itu penyampaian informasi melalui pendekatan kearifan lokal dirasa lebih tepat untuk diterapkan. Tujuan dari kegiatan ini adalah memberikan pemahaman kepada masyarakat umum terkait manajemen hipertensi dengan menggunakan pendekatan kearifan lokal agar lebih mudah di pahami. Hasil kegiatan ini meningkatkan pengetahuan tentang manajemen hipertensi, dimana 100% peserta memahami tentang informasi yang disampaikan dan mereka menjadi lebih mengerti. Pemberian Pendidikan Kesehatan seperti ini masih terus perlu dilakukan dan menjadi program wajib yang dilakukan oleh tenaga Kesehatan di berbagai tingkat pelayanan. Kata Kunci: Hipertensi, Manajemen Hipertensi, Pendidikan Kesehatan, Kearifan Lokal ABSTRACT Hypertension is still the cause of death in the world community, and still a challenge for the central and local governments in Indonesia in trying to provide an understanding to the public about the importance of knowing the risk factors that cause this disease. Risk factors that cause hypertension are coffee consumption, smoking, and alcohol consumption, and all three habitual patterns are closely related to the Manggarai regency. In Manggarai Regency, which is thick with traditional ceremonies and customs, mourning, associations, smoking, and alcohol consumption are becoming more frequent. There have been many efforts made by health workers, one of which is by providing health education, none the less, hypertension is still very high, so the delivery of information through a local wisdom approach is considered more appropriate to be applied. This action is to provide an understanding to the general public regarding hypertension management using local culture to make it easier to understand. The results of this activity increased knowledge about hypertension management, where 100% of participants understood the information and became more understanding. The provision of health education like this still needs to be done and is a mandatory program carried out by health workers at various levels. Keywords: Hypertension, Hypertension Management, Health Education, Local Culture
Program Pendidikan Kesehatan untuk Meningkatkan Pengetahuan Masyarakat tentang Barotrauma: Pengabdian kepada Masyarakat
Authors: Alfikrie Fauzan , Hidayat Uti Rusdian , Akbar Ali , Arisandi Defa , Nurpratiwi Nurpratiwi , Hatmalyakin Debby , Amaludin Mimi 
Published: January 2023

ABSTRAK Masalah barotrauma merupakan komplikasi serius dari kegawatdaruratan penyelaman. Masalah ini meningkat pada masyarakat yang yang sering melakukan aktivitas penyelaman seperti nelayan atau penyelam yang melakukan rekreasi bawah air. Terutama masyarakat yang memiliki pengetahuan yang kurang tentang keamanan saat menyelam. untuk meningkatkan pengetahuan masyarakat tentang barotrauma. metode pelaksanaan kegiatan pengabdian kepada masyarakat yaitu edukasi dengan metode ceramah dan tanya jawab tentang barotrauma. Hasil pelaksnaan pengabdian diperoleh tingkat pengetahuan masyarakat tentang barotrauma meningkat dari kategori pengetahuan cukup (100%) menjadi pengetahuan kategori baik (100%) setelah mendapat edukasi tentang barotrauma. Edukasi merupakan elemen penting untuk meningkatkan pengetahuan masyarkat tenteng barotrauma. Peningkatan pengetahuan masyarakat tentang barotrauma diharapkan dapat memberikan upaya preventif terhadap masalah-masalah kesehatan yang dapat dialami oleh penyelam. Kata Kunci: Edukasi Kesehatan, Barotrauma ABSTRACT Barotrauma is a serious complication of emergency diving. This problem is increasing in people who often do diving activities such as fishermen or divers who do underwater recreation. Especially people who have less knowledge about safety when diving. To increase public knowledge about barotrauma. The method of implementing the activities that have been carried out using education with the lecture method and question and answer about barotrauma. The results of the service implementation showed that the level of community knowledge about barotrauma increased from the moderate knowledge category (100%) to good knowledge (100%) after listening to education about barotrauma. Education is an important element to increase community knowledge about barotrauma. Increasing public knowledge about barotrauma is expected to provide preventive measures against health problems that can be experienced by divers. Keywords: Health Education, Barotrauma
Penyuluhan Daring Pemanfaatan Bakteri Baik untuk Hidup Sehat
Authors: Renesteen Editha , Wardhani Bantari Wisynu Kusuma 
Published: January 2023

ABSTRAK Mikrobiologi adalah ilmu yang mempelajari tentang semua mikroorganisme, seperti bakteri, fungi, alga, protozoa, dan archaea. Bakteri dapat bersifat sebagai bakteri baik dan bakteri yang dapat menyebabkan patogen. Bakteri baik merupakan sekumpulan bakteri yang mempunyai peran penting dalam membantu proses pencernaan serta penyerapan zat gizi dalam tubuh. Namun, masyarakat pada umumnya belum mengetahui perbedaan bakteri baik dan bakteri yang dapat menyebabkan pathogen. Penyuluhan tentang pemanfaatan bakteri baik untuk hidup sehat ini dilakukan untuk memberikan edukasi kepada masyarakat tentang pemanfaatan kekayaan biodiversitas mikroba Indonesia di berbagai bidang seperti kesehatan. Penyuluhan ini dilakukan melalui beberapa tahap, yaitu persiapan, pelaksanaan dan evaluasi. Penyuluhan dilakukan melalui kanal Zoom dan Youtube yang dikelola oleh Fakultas Farmasi Militer Universitas Pertahanan RI. Penyuluhan ini mengangkat tema Pemanfaatan bakteri baik untuk hidup sehat dengan mengundang pakar di bidang tersebut. Kegiatan penyuluhan dilakukan pada hari Sabtu, 14 Mei 2022 pukul 09.00-11.30 WIB dihadiri oleh 158 peserta masyarakat umum. Terjadi peningkatan pengetahuan dan pemahaman peserta penyuluhan terhadap pemanfaatan bakteri baik untuk hidup sehat. Kata Kunci: Penyuluhan, Bakteri Baik, Kesehatan, Probiotik ABSTRACT Microbiology is the study of all microorganisms, such as bacteria, fungi, algae, protozoa, and archaea. Bacteria can act as good bacteria and bacteria that can cause pathogens. Good bacteria are a group of bacteria that have an important role in helping the digestive process and absorption of nutrients in the body. However, people in general have limited informationabout the difference between good bacteria and bacteria that can cause pathogens. This counseling on the use of good bacteria for healthy living is carried out to provide education to the public about the use of Indonesia's rich microbial biodiversity in various fields such as health. This counseling is carried out through several stages, namely preparation, implementation and evaluation. Counseling is carried out through Zoom and Youtube channels which are managed by the Faculty of Military Pharmacy, Indonesian Defense University. This counseling raised the theme of Utilizing good bacteria for a healthy life by inviting experts in the field. The counseling activity was carried out on Saturday, May 14, 2022 at 09.00-11.30 WIB and was attended by 158 participants from the general public. There was an increase in knowledge and understanding of the counseling participants on the use of good bacteria for healthy living. Keywords: Counceling, Probiotic, Health
Pengaruh Terapi Akupresur terhadap Tekanan Darah pada Penderita Hipertensi
Authors: Saputra Adi , Pebriani Sintiya Halisya , Tafdhila Tafdhila , Syafe'i Abdul 
Published: January 2023

ABSTRACT Hypertension is a cardiovascular disease whose number continues to increase from year to year. Hypertension that occurs in the long term and is not treated will affect all organ systems of the body resulting in various complications that can lead to death. To prevent complications in hypertension, it is necessary to control hypertension, one of which is complementary therapy in the form of acupressure. This study aims to determine the difference in blood pressure in patients with hypertension before and after acupressure therapy. Quasy Experimental research design in the form of one group pretest and posttest design. The study was conducted at the Asy-Syaafi Holistic Center with a total sample of 20 hypertensive patients. Data analysis using Independent T-Test and Wilcoxon. The results showed that the average systolic blood pressure before acupressure therapy was 164.25 mmHg and the mean diastolic blood pressure was 100 mmHg. The average systolic blood pressure and blood pressure after acupressure therapy was 143.85 mmHg and the mean diastolic blood pressure was 90 mmHg. The results of statistical tests prove that there is a difference in systolic blood pressure (p value 0.000) and diastolic blood pressure (p value 0.025) before and after acupressure therapy. It was concluded that there was a difference in blood pressure before and after acupressure therapy was given. Keywords: Hypertension, Acupressure ABSTRAK Hipertensi merupakan salah satu penyakit kardiovaskuler yang jumlahnya tahun demi tahun terus mengalami peningkatan. Hipertensi yang terjadi dalam jangka waktu lama dan tidak diobati akan mempengaruhi semua sistem organ tubuh sehingga terjadi berbagai komplikasi yang dapat menyebabkan kematian. Untuk mencegah terjadinya komplikasi pada hipertensi maka diperlukan upaya pengendalian hipertensi yang salah satunya dengan terapi komplemnter berupa akupresur. Penelitian ini bertujuan untuk mengetahui perbedaan tekanan darah pada penderita hipertensi sebelum dan setelah dilakukan terapi akupresur. Desain penelitian dengan Quasy Eksperimen dengan bentuk rancangan one group pretest and posttest design. Penelitian dilakukan di Holistic Center Asy-Syaafi dengan jumlah sampel sebanyak 20 pasien hipertensi. Analis data menggunakan Independent T-Test dan Wilcoxon. Hasil penelitian didapatkan rata-rata tekanan darah sistolik sebelum terapi akupresur yaitu 164,25 mmHg dan pada tekanan darah diastolik didapatkan nilai tengah sebesar 100 mmHg. Rata-rata tekandan darah sistolik setelah dilakukan terapi akupresur yaitu 143,85 mmHg dan nilai tengah tekanan darah diastolik sebesar 90 mmHg. Hasil uji statistik membuktikan terdapat perbedaan tekanan darah sistolik (p value 0.000 ) dan tekanan darah diastolik (p value 0.025) sebelum dan sesudah terapi akupresur. Disimpulkan terdapat perbedaan tekanan darah sebelum dan sesudah diberikan terapi akupresur Kata Kunci: Hipertensi, Akupresure
Pola Hidup Sehat Selama Pandemi Covid-19 Pada kader PKK di Ciseeng Kabupaten Bogor
Authors: Mukhtar Diniwati , Weni Linda , Nedra Wan , Arsyad M , Suciati Yulia , Safira Dita 
Published: January 2023

Changes in lifestyle and modernization have caused a shift in the pattern of diseases from communicable to non-communicable diseases (NCD). The NCD category includes diabetes, hypertension, obesity, coronary heart disease. Non-communicable diseases are a challenge during the Covid-19 pandemic because they are comorbid, which will aggravate the disease. Therefore it is necessary to educate on a healthy lifestyle to avoid these new infectious diseases. The method was carried out through webinars with the topic of an active lifestyle, teachings on faith and introduction to herbs to PKK cadres (Family Welfare Empowerment – FWE) in Ciseeng village. The metabolic health characteristics have normal values of 0%, 26%, 100%, 74% for waist circumference (WC), body mass index (BMI), systolic and diastolic blood pressure, respectively. Knowledge of healthy lifestyle from the webinar increased from 51.30% to 85.96% (p <0.05). The conclusion is that the metabolic health of respondents is considered at risk, while webinar activities reduce the risk of comorbidities.
PEDAMPINGAN DAN PELATIHAN PENTINGNYA ASUPAN GIZI OPTIMAL DI PERIODE 1000 HARI PERTAMA KEHIDUPAN PADA KADER POSYANDU DI DESA CISEENG, BOGOR
Authors: Wuryanti Sri , Marsiati Himmi , Inayatullah Sofa 
Published: January 2023

Indonesia masih menghadapi permasalahan gizi yang serius., yaitu masalah kekurangan gizi, maupun kelebihan gizi. Malnutrisi pada periode 1000 hari pertama kehidupan (1000 HPK) bersifat permanen dan berjangka panjang, serta berpengaruh terhadap berbagai aspek kualitas sumber daya manusia.. Kecukupan gizi pada periode ini sangat menentukan kesehatan pada masa dewasa. Oleh karena itu perlu dilakukan intervensi sejak dini untuk mencegah terjadinya defisiensi gizi pada 1000 HPK untuk meminimalkan terjadinya kasus penyakit kronik degeneratif pada masa dewasa.
PKM Pusat YARA Universitas YARSI bekerjasama dengan petugas pemeritahan daerah Ciseeng-Bogor memberikan pendampingan dan pelatihan pada kader posyandu agar dapat menjadi kader yang terlatih dan dapat menjadi penggerak/motivator, serta mampu ikut memantau, mengenali, serta mengedukasi warganya yang berisiko tinggi mengalami masalah gizi (khususnya di periode 1000 HPK). Metode yang dilakukan pada kegiatan ini adalah dalam bentuk webinar yang diawali dengan pre-test untuk mengetahui tingkat pengetahuan peserta dan diakhiri dengan post-test untuk menilai tingkat pemahaman peserta. Hasil kegiatan didapatkan peningkatan pengetahuan peserta, sebesar 12,4%, dengan kepuasan peserta 89,3%.
PENERAPAN MODEL PEMBELAJARAN ROLE PLAYING UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA TEMA VIII KELAS SD NEGERI 060934 MEDAN
Authors: Sinaga Yuni  Sinaga Rayanti , Sinaga Reflina , Marianus Sumarlin Mangandar , Tanjung Darinda Sofia 
Published: January 2023

Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa dengan menerapkan model pembelajaran Role Playing pada Tema Daerah Tempat Tinggalku di kelas IV SD Negeri 060934 Kec. Medan Johor Tahun Pembelajaran 2021/2022. Subjek penelitian seluruh siswa kelas IV yang terdiri dari 11 siswa perempuan dan 11 siswa lai-laki. Teknik pengumpulan data yang digunakan yaitu observasi dan tes. Hasil penelitian menunjukkan adanya peningkatan hasil belajar siswa pada Tema Daerah Tempat Tinggalku. Hal ini terbukti dari hasil pretest terdapat 4 siswa yang tuntas (18,18%) sedangkan 18 siswa (81,82%) tidak tuntas dengan rata-rata sebesar 53. Pada postes siklus I terjadi peningkatan dengan 8 siswa (36,36%) yang tuntas dan 14 siswa yang tidak tuntas (63,64% ) yang tidak tuntas dengan rata-rata sebesar 66,3. Pada postes siklus II hasil belajar siswa meningkat terdapat 18 siswa (81,82%) yang tuntas dan 4 siswa yang tidak tuntas (18,18% ) tidak tuntas, dengan rata-rata 84,4. Selanjutnya hasil observasi aktivitas guru dalam pembelajaran siklus I diperoleh nilai rata-rata 48% dan observasi siswa 62%. PSiklus II hasil observasi guru meningkat menjadi 82% dan hasil observasi kegiatan siswa juga meningkat menjadi 88. Dangan demikian penggunaan model pembelajaran model role playing dapat meningkatan hasil belajar siswa pada tema daerah tempat tinggalku di kelas IV SD Negeri 060934 Kec. Medan Johor.
Application of thermosensitive-hydrogel combined with dental pulp stem cells on the injured fallopian tube mucosa in an animal model
Authors: Luo Lihua , Zhu Qunyan , Li Yejian , Hu Fengting , Yu Jiangtao , Liao Xiangyan , Xing Zhenjie , He Yan , Ye Qingsong 
Published: January 2023

Objectives: Fallopian tube (FT) injury is an important factor that can lead to tubal infertility. Stem-cell-based therapy shows great potential for the treatment of injured fallopian tube. However, little research has shown that mesenchymal stem cells (MSCs) can be used to treat fallopian tube damage by in situ injection. In this study, we in situ transplanted PF127 hydrogel encapsulating dental pulp stem cells (DPSCs) into the injured sites to promote the repair and regeneration of fallopian tube injury.Materials and methods: The properties of dental pulp stem cells were evaluated by flow cytometry, immunofluorescence analysis, and multi-differentiation detection. The immunomodulatory and angiogenic characteristics of dental pulp stem cells were analyzed on the basis of the detection of inflammatory factor expression and the formation of capillary-like structures, respectively. The biocompatibility of PF127 hydrogel was evaluated by using Live/Dead and CCK-8 assays. The effects of PF127 hydrogel containing dental pulp stem cells on the repair and regeneration of fallopian tube injury were evaluated by histological analysis [e.g., hematoxylin and eosin (H&amp;E) and Masson’s trichrome staining, TUNEL staining, immunofluorescence staining, and immunohistochemistry], Enzyme-linked immunosorbent assay (ELISA), and RT-PCR detections.Results: Dental pulp stem cells had MSC-like characteristics and great immunomodulatory and angiogenic properties. PF127 hydrogel had a thermosensitive feature and great cytocompatibility with dental pulp stem cells. In addition, our results indicated that PF127 hydrogel containing dental pulp stem cells could promote the repair and regeneration of fallopian tube damage by inhibiting cell apoptosis, stimulating the secretion of angiogenic factors, promoting cell proliferation, modulating the secretion of inflammatory factors, and restoring the secretion of epithelial cells.Conclusion: In this study, our results reported that in situ injection of PF127 hydrogel encapsulating dental pulp stem cells into the injured sites could provide an attractive strategy for the future treatment of fallopian tube injury in clinical settings.
Synthesis, optimization, and cell response investigations of natural-based, thermoresponsive, injectable hydrogel: An attitude for 3D hepatocyte encapsulation and cell therapy
Authors: Gholami Mahnaz , Tajabadi Maryam , Khavandi Alireza , Azarpira Negar 
Published: January 2023

For the purpose of developing a 3D vehicle for the delivery of hepatocytes in cell therapy, the improved system of crosslinker and new gelling agent combinations consisting of glycerophosphate and sodium hydrogen carbonate have been employed to produce injectable, thermoresponsive hydrogels based on chitosan and silk fibroin. Adjusting the polymer-to-gelling agent ratio and utilizing a chemical crosslinker developed hydrogel scaffolds with optimal gelling time and pH. Applying sodium hydrogen carbonate neutralizes chitosan while keeping its thermoresponsive characteristics and decreases glycerophosphate from 60% to 30%. Genipin boosts the mechanical properties of hydrogel without affecting the gel time. Due to their stable microstructure and lower amine availability, genipin-containing materials have a low swelling ratio, around six compared to eight for those without genipin. Hydrogels that are crosslinked degrade about half as fast as those that are not. The slowerr degradation of Silk fibroin compared to chitosan makes it an efficient degradation inhibitor in silk-containing formulations. All of the optimized samples showed less than 5% hemolytic activity, indicating that they lacked hemolytic characteristics. The acceptable cell viability in crosslinked hydrogels ranges from 72% to 91% due to the decreasing total salt concentration, which protects cells from hyperosmolality. The pH of hydrogels and their interstitial pores kept most encapsulated cells alive and functioning for 24 h. Urea levels are higher in the encapsulation condition compared to HepG2 cultivated alone, and this may be due to cell-matrix interactions that boost liver-specific activity. Urea synthesis in genipin crosslinked hydrogels increased dramatically from day 1 (about 4 mg dl−1) to day 3 (approximately 6 mg dl−1), suggesting the enormous potential of these hydrogels for cell milieu preparation. All mentioned findings represent that the optimized system may be a promising candidate for liver regeneration.
Role of follistatin-like 1 levels and functions in calcific aortic stenosis
Authors: Zhang Qianru , Ye Jiawen , Yang Gan , Yang Ling , Chen Zhongli , Yang Ke , Sun Jia Teng , Liu Yan 
Published: January 2023

BackgroundCalcific aortic valve disease (CAVD) is a progressive disease resulting in severe calcific aortic stenosis (AS), and there is increasing interest in the discovery of novel biomarkers to identify patients with potential future calcific AS at an early stage. This study aimed to determine whether follistatin-like 1 (FSTL1) is associated with calcific AS events and its exact role in aortic valve calcification.MethodsA prospective observational cohort study involving 656 patients was performed to investigate the relationship between serum FSTL1 and calcific AS incidence during a follow-up of 5 years. Furthermore, we detected FSTL1 levels in valvular interstitial cells (VICs) from calcified valves and explored the effects of FSTL1 on VIC osteogenic differentiation in vitro as well as the signaling pathways involved.ResultsDuring a median follow-up of 5 years, lower FSTL1 levels were associated with a significantly higher risk of calcific AS events (log rank test, P = 0.007). In addition, Cox multivariable regression analyses verified the predictive value of FSTL1 after adjusting for both demographic features and laboratory confounders. Consistent with our results for serum, a lower concentration of FSTL1 was observed in calcified human valves (n = 11) and mainly colocalized with VICs. Recombinant human FSTL1 (rhFSTL1) stimulation inhibited calcium deposition, alkaline phosphatase (ALP) activity, and osteogenic gene expression partly through the downregulation of the ERK1/2 pathway.ConclusionTaken together, this study provides a strong rationale to consider FSTL1 as a potential therapeutic target for calcific AS.
A bibliometric analysis on the progress of myocardial bridge from 1980 to 2022
Authors: Chen Liang , Yu Wen-Yuan , Liu Rui , Gao Ming-Xin , Wang Bo-Lin , Ding Xiao-Hang , Yu Yang 
Published: January 2023

IntroductionAlthough the vast majority of patients with a myocardial bridge (MB) are asymptomatic, the anomaly was found to be associated with stable or unstable angina, vasospastic angina, acute coronary syndrome, and even malignant arrhythmias and sudden cardiac death in some cases.MethodsBy retrieving the relevant literature on MB from 1 January 1980 to 31 July 2022 from the Web of Science Core Collection (WoSCC) database, we used the bibliometric tools, including CiteSpace, VOS viewer, and alluvial generator, to visualize the scientific achievements on MB.ResultsA total of 630 articles were included. The number of published articles was in a fluctuating growth trend. These publications came from 37 contries, led by the USA and China. The leading country on MB was the United States, the leading position among institutions was Stanford University, and the most productive researcher on MB was Jennifer A. Tremmel. After analysis, the most common keywords were myocardial bridge, mortality, coronary angiography, descending coronary artery, and sudden death.ConclusionOur findings can aid researchers in understanding the current state of MB research and in choosing fresh lines of inquiry for forthcoming investigations. Prevalence and prognosis, mechanism atherosclerosis, hemodynamic significance, and molecular autops will likely become the focus of future research. In addition, more studies and cooperations are still needed worldwide.