bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network Preservation Analysis Reveals Dysregulated Metabolic Pathways in Human Vascular Smooth Muscle Cell Phenotypic Switching
Authors: Perry R. Noah , Albarracin Diana , Aherrahrou Redouane , Civelek Mete 
Published: June 2023

BACKGROUND:
Vascular smooth muscle cells are key players involved in atherosclerosis, the underlying cause of coronary artery disease. They can play either beneficial or detrimental roles in lesion pathogenesis, depending on the nature of their phenotypic changes. An in-depth characterization of their gene regulatory networks can help better understand how their dysfunction may impact disease progression.

METHODS:
We conducted a gene expression network preservation analysis in aortic smooth muscle cells isolated from 151 multiethnic heart transplant donors cultured under quiescent or proliferative conditions.

RESULTS:
We identified 86 groups of coexpressed genes (modules) across the 2 conditions and focused on the 18 modules that are least preserved between the phenotypic conditions. Three of these modules were significantly enriched for genes belonging to proliferation, migration, cell adhesion, and cell differentiation pathways, characteristic of phenotypically modulated proliferative vascular smooth muscle cells. The majority of the modules, however, were enriched for metabolic pathways consisting of both nitrogen-related and glycolysis-related processes. Therefore, we explored correlations between nitrogen metabolism-related genes and coronary artery disease–associated genes and found significant correlations, suggesting the involvement of the nitrogen metabolism pathway in coronary artery disease pathogenesis. We also created gene regulatory networks enriched for genes in glycolysis and predicted key regulatory genes driving glycolysis dysregulation.

CONCLUSIONS:
Our work suggests that dysregulation of vascular smooth muscle cell metabolism participates in phenotypic transitioning, which may contribute to disease progression, and suggests that AMT (aminomethyltransferase) and MPI (mannose phosphate isomerase) may play an important role in regulating nitrogen and glycolysis-related metabolism in smooth muscle cells.
The Role of Morphological Variation in Evolutionary Robotics: Maximizing Performance and Robustness
Authors: Carvalho Jonata Tyska , Nolfi Stefano 
Published: June 2023

Abstract
Exposing an evolutionary algorithm that is used to evolve robot controllers to variable conditions is necessary to obtain solutions which are robust and can cross the reality gap. However, we do not yet have methods for analyzing and understanding the impact of the varying morphological conditions which impact the evolutionary process, and therefore for choosing suitable variation ranges. By morphological conditions, we refer to the starting state of the robot, and to variations in its sensor readings during operation due to noise. In this paper, we introduce a method that permits us to measure the impact of these morphological variations and we analyze the relation between the amplitude of variations, the modality with which they are introduced, and the performance and robustness of evolving agents. Our results demonstrate that (i) the evolutionary algorithm can tolerate morphological variations which have a very high impact, (ii) variations affecting the actions of the agent are tolerated much better than variations affecting the initial state of the agent or of the environment, and (iii) improving the accuracy of the fitness measure through multiple evaluations is not always useful. Moreover, our results show that morphological variations permit generating solutions which perform better both in varying and non-varying conditions.
Territorial Differential Meta-Evolution: An Algorithm for Seeking All the Desirable Optima of a Multivariable Function
Authors: Wehr Richard , Saleska Scott R. 
Published: June 2023

Abstract
Territorial Differential Meta-Evolution (TDME) is an efficient, versatile, and reliable algorithm for seeking all the global or desirable local optima of a multivariable function. It employs a progressive niching mechanism to optimize even challenging, high-dimensional functions with multiple global optima and misleading local optima. This paper introduces TDME and uses standard and novel benchmark problems to quantify its advantages over HillVallEA, which is the best-performing algorithm on the standard benchmark suite that has been used by all major multimodal optimization competitions since 2013. TDME matches HillVallEA on that benchmark suite and categorically outperforms it on a more comprehensive suite that better reflects the potential diversity of optimization problems. TDME achieves that performance without any problem-specific parameter tuning.
Parameterless Gene-Pool Optimal Mixing Evolutionary Algorithms
Authors: Dushatskiy Arkadiy , Virgolin Marco , Bouter Anton , Thierens Dirk , Bosman Peter A. N. 
Published: June 2023

Abstract
When it comes to solving optimization problems with evolutionary algorithms (EAs) in a reliable and scalable manner, detecting and exploiting linkage information, that is, dependencies between variables, can be key. In this paper, we present the latest version of, and propose substantial enhancements to, the gene-pool optimal mixing evolutionary algorithm (GOMEA): an EA explicitly designed to estimate and exploit linkage information. We begin by performing a large-scale search over several GOMEA design choices to understand what matters most and obtain a generally best-performing version of the algorithm. Next, we introduce a novel version of GOMEA, called CGOMEA, where linkage-based variation is further improved by filtering solution mating based on conditional dependencies. We compare our latest version of GOMEA, the newly introduced CGOMEA, and another contending linkage-aware EA, DSMGA-II, in an extensive experimental evaluation, involving a benchmark set of nine black-box problems that can be solved efficiently only if their inherent dependency structure is unveiled and exploited. Finally, in an attempt to make EAs more usable and resilient to parameter choices, we investigate the performance of different automatic population management schemes for GOMEA and CGOMEA, de facto making the EAs parameterless. Our results show that GOMEA and CGOMEA significantly outperform the original GOMEA and DSMGA-II on most problems, setting a new state of the art for the field.
Cold War History Studies in China in the 21st Century: The State of the Field
Authors: Liang Zhi , Xia Yafeng 
Published: June 2023

Abstract
This survey explains how the field of Cold War studies has been able to survive and even flourish in the People's Republic of China (PRC) from 2000 to the present, despite all the practical and political obstacles. It reviews several areas that Chinese scholars have been exploring: the economic Cold War; foreign intelligence operations and psychological warfare; nuclear strategies; the sciences during the Cold War and overseas education projects; and China's policies toward neighboring countries during the Cold War. The article outlines the major practical challenges facing Chinese scholars and the potential for overcoming these challenges.
From Ritual Scapegoats to Actual Scapegoats
Authors: Pal Satanik 
Published: June 2023

Abstract
The following article conducts two case studies into the premodern caste societies of medieval Bengal and early modern Japan. The Pirali Brahmins in Bengal and eta-hinin castes of Japan—both became scapegoats during these periods and were subject to popular disgust and stigma. The common aspects are that they were both close to the centres of power, and that these castes were feared in the ancient period for their supernatural prowess and they served as ritual scapegoats in pollution cleaning rituals. How they both became actual scapegoats from being ritual scapegoats is explored in this article using the framework popularized by the works of René Girard.
Chinese Perspectives on Sustainable Development
Authors: Burnay Matthieu , Li Bin 
Published: June 2023

Abstract
Growing multipolarity in international affairs together with the rise of non-state actors do require us to re-think what constitutes sustainable development, in general, but also how economic growth can be respectful of the environment and individual rights. The People’s Republic of China (China) does constitute an important part of that story. This paper aims to analyse China’s discourse, laws, and policies on sustainable development at both national and international levels. It situates sustainable development in the broader context of China’s current development policy; addresses the ways in which China engages with multilateral and bilateral institutions (i.e. legal instruments) in the area of sustainable development; as well as assesses the scope and limitations of China’s focus on sustainable development in the context of Outward Foreign Direct Investment in the framework of the Belt and Road Initiative.
The Vatican Library’s “Statue of Saint Hippolytus” Revisited
Authors: Bencze Ágnes , Prampolini Franco 
Published: June 2023

Abstract
An archaeologist-art historian and an IT scientist specialised in the restoration of architectural and artistic heritage present the scheme of a multidisciplinary research project concerning a long-debated monument, the so-called St. Hippolytus’ statue of the Vatican Library. Inspired by some questions and observations arising from different fields of humanistic sciences, we created a virtual 3D model of the statue. In this paper we propose some ways to exploit it as a research instrument.
Non-protective immunity after standard pneumococcal vaccination series identified as a potential contributing risk factor for refractory otolaryngologic conditions in children
Authors: Bonaventure Caroline A. , Evans Adele K. 
Published: June 2023

Objective: To examine the relationship between conferred immunity after standard pneumococcal series and refractory otolaryngologic infections in pediatric patients using post-vaccination antibody titers, and to identify contributory underlying conditions revealed when vaccination/re-vaccination fails to confer protective immunity. Study Design: IRB-reviewed and “exempt” retrospective case series with chart review using the Epic® Electronic Medical Record system from 2013 to 2021. Setting: Dedicated tertiary referral children’s hospital. Methods: Pneumococcal antibody titer results were assessed for children ages 0 to 21 years and: (1) at least 1 of 7 otolaryngologic disease diagnoses and (2) having received the 4-dose schedule of pneumococcal conjugate vaccine (PCV 7 or 13). Results: A total of 241 subjects met inclusion criteria with 356 laboratory tests. Recurrent acute otitis media, chronic rhinitis, and chronic otitis media with effusion were the 3 most frequent diagnoses. At presentation, only 27.0% of subjects had titers conferring immunity from their prior vaccinations with PCV. About 85 subjects had been subsequently revaccinated with Pneumococcal Polysaccharide Vaccine (PPSV), and antibody responses conferring immunity reached 91.8%. Seven subjects never developed adequate responses; 5 of these had recurrent acute otitis media as the primary otolaryngologic diagnosis. Secondary “revealed” diagnoses included Juvenile Rheumatoid Arthritis (n = 1), unresolved specific antibody deficiency (n = 2), and Hypogammaglobulinemia (n = 1). Conclusion: In pediatric patients with recurrent infectious otolaryngologic disease refractory to traditional medical and surgical therapy, inadequate responses to pneumococcal vaccination may be revealed. This correlation represents a potential pathway for diagnosis and therapy.
Exploring the Bereavement Experience Due to COVID-19 Death Among Arabs in Israel
Authors: Khatib Anwar , Abo-Rass Fareeda , Khatib Ahmad 
Published: June 2023

This study examined the experience of bereavement because of COVID-19 among the Arab minority in Israel, based on the two-track model of grief, using a qualitative approach. The data was collected in an in-depth interview with 34 participants representing the three religions in the Arab population in Israel, approximately 1 year after the loss occurred. The findings revealed that most participants reported returning to their previous function almost completely, exclusively in the field of work. However, they reported decreased social functioning and feelings of loneliness and sadness, and some reported manifestations of active and traumatic grief. Some findings may create a false impression that the mourners have gone through the loss process and returned to normal. However, the current study’s findings refute this conclusion, which requires appropriate treatment from health professionals.
Low accuracy in preoperative tissue biopsies for diagnosing chronic periprosthetic joint infection: an observational retrospective single-centre study
Authors: Eriksson Hannah , Lazarinis Stergios 
Published: June 2023

Objective Diagnosing periprosthetic joint infection (PJI) can be challenging. The ability to distinguish between septic and aseptic failure of a joint prosthesis is crucial for treatment strategy optimisation and prognosis prediction. Preoperative tissue cultures are included in many diagnostic algorithms; however, studies report different degrees of concordance (63%–85%) with intraoperative cultures. This study aimed to investigate the diagnostic performance of tissue biopsies in the preoperative diagnostic process with the 2018 International Consensus Meeting criteria as a reference and to describe the concordance between microbiological findings in pre- and intraoperative biopsies. Methods This observational retrospective study included 44 patients requiring revision surgery of a total hip or knee arthroplasty, where the diagnostic workup included biopsies of periprosthetic tissue. The accuracy of preoperative biopsies was calculated, and concordance between microbiological findings in pre- and intraoperative biopsies was described. Results The accuracy was 59%, with a sensitivity of 50% and specificity of 79%. Full concordance between microbiological findings in pre- and intraoperative biopsies was found in 64% of the cases. Conclusion An open biopsy of periprosthetic tissue cannot reliably confirm or exclude PJI, and, therefore, should not be performed.
Impact of cytotoxic chemotherapy on aldo-keto reductase family 1 member B10 expression
Authors: Robinson Kathy , Cao Zhe , Delfino Kristin , Cao Deliang , Rao Krishna 
Published: June 2023

Objective Aldo-keto reductase family 1 member B10 (AKR1B10) is a protein that is produced and secreted by a significant number of breast cancers. However, a potential confounder to the use of AKR1B10 as a tumor marker is its elevation in patients given cytotoxic chemotherapy. We therefore conducted a prospective study to analyze AKR1B10 levels in patients with breast cancer receiving neoadjuvant cytotoxic chemotherapy. Methods The study enrolled 10 patients from November 2015 to July 2017. All patients had locally advanced, but non-metastatic, breast cancer, and they received neoadjuvant chemotherapy followed by surgery. Serum AKR1B10 levels and tumor imaging were assessed before, during, and after chemotherapy. Results No increase in serum AKR1B10 levels was noted in patients receiving chemotherapy whose levels were elevated at diagnosis. Conclusion The findings are complex, but the overall data suggest that AKR1B10 is suitable as a tumor marker in patients with elevated levels at the time of diagnosis.
A Ptolemaic Stamped Amphora from Patara: Some Notes on Stamp Attribution and its Likely Implications
Authors: Dündar Erkan 
Published: June 2023

Located in ancient Lycia at the southwest corner of Asia Minor, excavations at the important port city of Patara shed new light on the city’s relations with Ptolemaic Egypt. The most significant finds concerning Patara’s connection with the Ptolemaic Dynasty have emerged from ongoing fieldwork at the Tepecik settlement, located on a natural hill just east of the ancient inner harbour. During excavations conducted there in 2019, an ancient dump of pottery was identified in the İ-20 trench. The focus of this study concerns a unique stamped Egyptian amphora found in this dump. The stamp records the name Ptolemaios alongside a regnal year, thus indicating that the amphora represents royal production during the third century BC. In this study, I suggest that the name on the stamp should be attributed to King Ptolemy III Euergetes (246–222 BC) and explore the likely implications of royal production. [Formula: see text]
The Forgotten Excavation at Tell Basta: New Information on the Graeco-Egyptian Bath and the Context of Gold and Silver Objects Discovered in 1906
Authors: Laube Kacper 
Published: June 2023

In 1906, the workers levelling the archaeological site of Tell Basta uncovered a group of objects known as the first hoard of Tell Basta. Soon after this discovery, the Service des Antiquités carried out a small-scale excavation during which a small deposit was uncovered along with a second hoard and the remains of a Graeco-Egyptian bath. Unfortunately, the exact locations of the discoveries made in 1906 were not recorded, and published descriptions concerning their context are still a matter of controversy. Recently the author of this paper discovered a letter with previously unknown photographs, which are discussed in this paper and shed new light on the context of the discoveries made at Tell Basta in 1906. [Formula: see text]
Deep Learning Reconstruction Plus Single-Energy Metal Artifact Reduction for Supra Hyoid Neck CT in Patients With Dental Metals
Authors: Mizuki Masumi , Yasaka Koichiro , Miyo Rintaro , Ohtake Yuta , Hamada Akiyoshi , Hosoi Reina , Abe Osamu 
Published: June 2023

Purpose: We investigated the effect of deep learning reconstruction (DLR) plus single-energy metal artifact reduction (SEMAR) on neck CT in patients with dental metals, comparing it with DLR and with hybrid iterative reconstruction (Hybrid IR)–SEMAR. Methods: In this retrospective study, 32 patients (25 men, 7 women; mean age: 63 ± 15 years) with dental metals underwent contrast-enhanced CT of the oral and oropharyngeal regions. Axial images were reconstructed using DLR, Hybrid IR–SEMAR, and DLR-SEMAR. In quantitative analyses, degrees of image noise and artifacts were evaluated. In one-by-one qualitative analyses, 2 radiologists evaluated metal artifacts, the depiction of structures, and noise on five-point scales. In side-by-side qualitative analyses, artifacts and overall image quality were evaluated by comparing Hybrid IR–SEMAR with DLR-SEMAR. Results: Artifacts were significantly less with DLR-SEMAR than with DLR in quantitative ( P < .001) and one-by-one qualitative ( P < .001) analyses, which resulted in significantly better depiction of most structures ( P < .004). Artifacts in side-by-side analysis and image noise in quantitative and one-by-one qualitative analyses ( P < .001) were significantly less with DLR-SEMAR than with Hybrid IR–SEMAR, resulting in significantly better overall quality of DLR-SEMAR. Conclusions: Compared with DLR and Hybrid IR–SEMAR, DLR-SEMAR provided significantly better supra hyoid neck CT images in patients with dental metals.
Does CSR Make Business? Insights from Structural Equation Model Analysis of Indian Companies
Authors: Mohanty Siba Sankar , Rath Subhrajit 
Published: June 2023

The study contributed to the debate on the link between CSR and financial performance of the corporate sector on the basis of information on CSR and financial performance indicators (CFP) for top 100 listed companies in India between 2005 and 2020. Structural equation modelling tools were used to assess the relationship between the composite variables CSR and CFP. The companies were also classified into two groups namely, mineral-based and non-mineral-based.The study found a significant and positive effect of CSR on CFP. However, the study found interesting differences in the route of such effect for mineral and non-mineral groups of companies. While the positive CSR-CFP relationship in non-mineral-based companies was primarily due to enhancement in their internal resource management efficiency and increase in productivity, for mineral-based companies, it was more driven by legitimacy and community reputation concerns.
A Study of Reliability and Validity of Constructs of Neuromarketing Among Indian Consumers
Authors: Traymbak Shruti , Shukla Anju , Dutta Mili 
Published: June 2023

Background Consumer behavior research and neurology are combined in the emerging discipline of neuromarketing. Neuromarketing is considered to be one of emerging field to study how consumer’s brain reacts to advertisement and other brand’s message by observing brainwave, eye, and skin response. The current study examined the emerging field of constructs of neuromarketing like social, attention, technology, and emotions to examine Indian consumer’s buying behavior. Purpose To study the validity and reliability of constructs of neuromarketing that examines consumer’s buying behavior among Indian consumers. Methods A sample of 191 people of different age groups was considered in the study. A random sampling technique was used for data collection. The self-designed questionnaire used for the measurement of neuromarketing constructs and consumers’ buying behavior. The current study applied SPSS and AMOS software to validate the measurement model of neuromarketing. Results The Kaiser-Meyer-Olkin (KMO) and Bartlett’s Test’s value is 0.784 and this value confirmed that the sample is adequate for factor analysis. Apart from that, the five constructs of neuromarketing – Attention (A), Social (SC), Technological (T), Emotion (E), and Consumer Buying Behavior (BB) had shown the value of Cronbach’s alpha to be more than 0.7. Confirmatory Factor Analysis (CFA) had shown value of average variance explained of each constructs 0.5 and composite reliability more than 0.7 which indicates excellent construct validity of constructs for model formation of neuromarketing. The study also validates measurement research model of neuromarketing on the basis of model fit index (chi-square/df = 3.397, RMSEA = 0.10, GFI = 0.92, and CFI = 0.87). Conclusion The present study had shown good validity and reliability of constructs of neuromarketing and also proved that marketers can apply these constructs to examine behavior pattern of consumers.