bluuebunny/crossref_metadata_2025_split huggingface dataset:
Letter: Mendelian randomization—New perspective in inflammatory bowel disease and pancreatic cancer?
Authors: Min Yu , Wei Xiaoyuan , Peng Xingchen 
Published: June 2023

LINKED CONTENTThis article is linked to Massironi et al papers. To view these articles, visit https://doi.org/10.1111/apt.16949 and https://doi.org/10.1111/apt.17552
Letter: childhood recurrent abdominal pain is associated with increased duodenal eosinophilia independent of Helicobacter pylori infection
Authors: Wauters Lucas , Harris Paul R. , Walker Marjorie M. , Serrano Carolina A. , Villagrán Andrea , Rakhra Gurpreet S. , Crabtree Jean E. , Talley Nicholas J. 
Published: June 2023

LINKED CONTENTThis article is linked to Broeders et al paper. To view this article, visit https://doi.org/10.1111/apt.17414
Reconciling impact and participation: Reflections on collaborating with specialist organisations for PhD research
Authors: Hayes Sylvia , Manktelow Chris 
Published: June 2023

AbstractRecent debates within Geography have discussed the benefits of collaborating with non‐academic partners in research (e.g. Campbell & Vanderhoven, 2016, Knowledge that matters: Realising the potential of Co‐production. Manchester, UK: N8 Research Partnership; Holt et al., 2019, Area, 51, 390). We discuss these debates in relation to two key concepts in Geography: Impact and Participation. In this article, we critically reflect on our own experiences as PhD researchers conducting collaborative research projects, discussing the outcomes, challenges and ‘expectations gaps’ of collaboration with non‐academic partners (Flinders et al., 2016, Evidence & Policy, 12, 261, p. 269). Our contribution lies in our reflections on collaboratively producing knowledge through being embedded in non‐academic expert organisations. Much of the debate in Geography has focused on collaboration with marginalised groups or vulnerable communities (e.g. Holt et al., 2019, 2019, Area, 51, 390), and we add to these debates with the experiences of collaborating with two expert organisations: a specialist climate journalism organisation (Carbon Brief); and a government organisation (Met Office). First, we discuss the varying forms of impact that were produced through conducting our research collaboratively, not only through improving the quality of our academic outputs through ‘ontological transformation’ (Barry et al., 2008, Economy and Society, 37, 20, p. 20), but also ‘real‐world’, actionable impacts for the collaborative partners. We relate both these experiences to ideas of impact which go beyond the REF Impact Agenda, specifically finding important the concept of ‘impact‐in‐process’ (Marzi, 2022, Area). Second, we discuss the ethical complexities and power dynamics involved with embedding a researcher in an expert organisation. We highlight the need for broader conceptions of ethnical research, drawing particularly from Campbell and Vanderhoven's ‘ethical state of mind’ (2016, p. 30). In sum, we argue that although PhD research which is produced collaboratively with expert organisations can produce practical benefits to both researcher and partner, there are important discussions around power dynamics and ethics which can prevent PhD research done in this way from fully realising the transformational potential of collaboration.
Virtual drug screen reveals context‐dependent inhibition of cardiomyocyte hypertrophy
Authors: Eggertsen Taylor G. , Saucerman Jeffrey J. 
Published: June 2023

Background and PurposePathological cardiomyocyte hypertrophy is a response to cardiac stress that typically leads to heart failure. Despite being a primary contributor to pathological cardiac remodelling, the therapeutic space that targets hypertrophy is limited. Here, we apply a network model to virtually screen for FDA‐approved drugs that induce or suppress cardiomyocyte hypertrophy.Experimental ApproachA logic‐based differential equation model of cardiomyocyte signalling was used to predict drugs that modulate hypertrophy. These predictions were validated against curated experiments from the prior literature. The actions of midostaurin were validated in new experiments using TGFβ‐ and noradrenaline (NE)‐induced hypertrophy in neonatal rat cardiomyocytes.Key ResultsModel predictions were validated in 60 out of 70 independent experiments from the literature and identify 38 inhibitors of hypertrophy. We additionally predict that the efficacy of drugs that inhibit cardiomyocyte hypertrophy is often context dependent. We predicted that midostaurin inhibits cardiomyocyte hypertrophy induced by TGFβ, but not noradrenaline, exhibiting context dependence. We further validated this prediction by cellular experiments. Network analysis predicted critical roles for the PI3K and RAS pathways in the activity of celecoxib and midostaurin, respectively. We further investigated the polypharmacology and combinatorial pharmacology of drugs. Brigatinib and irbesartan in combination were predicted to synergistically inhibit cardiomyocyte hypertrophy.Conclusion and ImplicationsThis study provides a well‐validated platform for investigating the efficacy of drugs on cardiomyocyte hypertrophy and identifies midostaurin for consideration as an antihypertrophic drug.
Preventable burden of head and neck cancer attributable to tobacco and alcohol between 1990 and 2039 in China
Authors: Song Cheng , Chen Yahan , Qiao Youlin 
Published: June 2023

AbstractTobacco use and heavy alcohol consumption are risk factors for head and neck cancer (HNC), including oral, pharynx, and larynx cancer. No study has investigated the preventable burden of HNC attributable to tobacco and alcohol in China. We extracted data from 1990 to 2019 from the Global Burden of Disease. The preventable burden attributable to tobacco and alcohol was estimated by subtracting the overlapping fraction derived from a literature search. Descriptive analyses were performed initially, followed by joinpoint regression and age‐period‐cohort (APC) analysis. The future burden was forecasted using a Bayesian APC model. The crude burden increased significantly, while the age‐standardized rates showed a downward trend from 1990 to 2019 in China. Both all‐age and age‐standardized population attributable fractions rose significantly, potentially due to the poor prognosis of tobacco‐ and alcohol‐associated HNC. The absolute burden would continue to climb in the next 20 years from 2019, largely due to population aging. For site‐specific burden, compared with total, pharynx, and larynx cancer burden, the substantial upward trend of oral cancer burden indicated a strong interaction with risk factors such as genetic susceptibility, betel nut chewing, oral microbiota, and human papillomavirus. The burden of oral cancer attributable to tobacco and alcohol is a major concern and is anticipated to become more severe than cancer in other anatomic sites. Altogether, our study provides useful information to rethink the current restrictions on tobacco and alcohol, lean healthcare resources, and develop effective HNC prevention and control strategies.
Infant‐directed speech does not always involve exaggerated vowel distinctions: Evidence from Danish
Authors: Cox Christopher , Dideriksen Christina , Keren‐Portnoy Tamar , Roepstorff Andreas , Christiansen Morten H. , Fusaroli Riccardo 
Published: June 2023

AbstractThis study compared the acoustic properties of 26 (100% female, 100% monolingual) Danish caregivers' spontaneous speech addressed to their 11‐ to 24‐month‐old infants (infant‐directed speech, IDS) and an adult experimenter (adult‐directed speech, ADS). The data were collected between 2016 and 2018 in Aarhus, Denmark. Prosodic properties of Danish IDS conformed to cross‐linguistic patterns, with a higher pitch, greater pitch variability, and slower articulation rate than ADS. However, an acoustic analysis of vocalic properties revealed that Danish IDS had a reduced or similar vowel space, higher within‐vowel variability, raised formants, and lower degree of vowel discriminability compared to ADS. None of the measures, except articulation rate, showed age‐related differences. These results push for future research to conduct theory‐driven comparisons across languages with distinct phonological systems.
Negotiating power dynamics through co‐reflexivity in research with young children in disadvantaged communities
Authors: El Gemayel Sandra Marie , Salema Yaspia 
Published: June 2023

AbstractThis paper addresses how unequal power dynamics in research with young children in disadvantaged communities can be negotiated through co‐reflexivity. It explores this through two different projects, the “London Study” and the “Beirut Study”, which researched the play of young children from families living with disadvantage in two distinct cultures. First, we highlight similarities between both studies' methodological and ethical approaches that were designed to ‘listen’ to the children, ensure ‘ongoing consent’ and co‐create knowledge through co‐reflexivity. We then draw on data from each study to demonstrate how, in their unique contexts, co‐reflexivity was crucial to address researcher–child power dynamics.
Functional connectomes of akinetic‐rigid and tremor within drug‐naïve Parkinson's disease
Authors: Wu Haoting , Zhou Cheng , Guan Xiaojun , Bai Xueqin , Guo Tao , Wu Jingjing , Chen Jingwen , Wen Jiaqi , Wu Chenqing , Cao Zhengye , Liu Xiaocao , Gao Ting , Gu Luyan , Huang Peiyu , Xu Xiaojun , Zhang Baorong , Zhang Minming 
Published: June 2023

AbstractAimsTo detect functional connectomes of akinetic‐rigid (AR) and tremor and compare their connection pattern.MethodsResting‐state functional MRI data of 78 drug‐naïve PD patients were enrolled to construct connectomes of AR and tremor via connectome‐based predictive modeling (CPM). The connectomes were further validated with 17 drug‐naïve patients to verify their replication.ResultsThe connectomes related to AR and tremor were identified via CPM method and successfully validated in the independent set. Additional regional‐based CPM demonstrated neither AR nor tremor could be simplified to functional changes within a single brain region. Computational lesion version of CPM revealed that parietal lobe and limbic system were the most important regions among AR‐related connectome, and motor strip and cerebellum were the most important regions among tremor‐related connectome. Comparing two connectomes found that the patterns of connection between them were largely distinct, with only four overlapped connections identified.ConclusionAR and tremor were found to be associated with functional changes in multiple brain regions. Distinct connection patterns of AR‐related and tremor‐related connectomes suggest different neural mechanisms underlying the two symptoms.
The Relationship Between Word Length and Average Information Content in Japanese
Authors: Tanida Yuki 
Published: June 2023

AbstractPiantadosi, Tily, and Gibson analyzed a large‐scale web‐scraping corpus (the Google 1T dataset) and reported that word length is independently predicted from average information content (surprisal) calculated by a 2‐ to 4‐gram model (hereafter, longer‐span surprisal) across 11 Indo‐European languages, namely, Czech, Dutch, English, French, German, Italian, Polish, Spanish, Portuguese, Romanian, and Swedish. However, a recent article by Meylan and Griffiths suggested the importance of preprocessing for studies with large‐scale corpora and reanalyzed the same databases. After their preprocessing, the results in Piantadosi et al. were not replicated in Czech, Romanian, and Swedish. Additionally, a German‐specific study by Koplenig, Kupietz, and Wolfer showed that the strict analysis did not replicate the result in Piantadosi et al. for that language with the preprocessing suggested by Meylan and Griffiths in a large‐scale but less noisy database. These three studies provide evidence from 11 Indo‐European languages and one Afro‐Asiatic language, Hebrew, as relevant in this debate. However, we do not have evidence from other linguistic groups. This study provides evidence about Japanese based on a strict preprocessing of Google's web‐scraping database. The results show that Japanese word length can be predicted independently by 2‐ to 4‐gram surprisal.
Covid‐19 positive donor utilization for heart transplantation: The new frontier for donor pool expansion
Authors: Vaidya Gaurang Nandkishor , Anaya Paul , Ignaszewski Maya , Kolodziej Andrew , Malyala Rajasekhar , Rajagopalan Navin , Sekela Michael , Birks Emma 
Published: June 2023

AbstractBackground: Hearts from COVID‐19 positive donors (CPD) are being utilized for heart transplantation by some centers; however, this is in the setting of the lack of guidelines or robust evidence. The paucity of evidence is reflected in the recent Organ Procurement and Transplantation Network (OPTN) communication describing CPD utilization as an “unknown risk.” Methods and Results: We analyzed the UNOS database for adult heart transplants performed between January 2021 to December 2022, and CPD comprised of a significant percentage of donors, being used in >10% of recipients in some UNOS regions. Between July 2022 and December 2022, 7.9% of heart transplants were with CPD, and in the same period Hepatitis C positive donors accounted for 7.1% and donation after circulatory death (DCD) accounted for 10.3%. Conclusion: If the transplant community comes up with a standardized approach and guidance in using CPD hearts, this could provide an effective donor pool expansion strategy.
Automatic body part identification in real‐world clinical dermatological images using machine learning
Authors: Sitaru Sebastian , Oueslati Talel , Schielein Maximilian C , Weis Johanna , Kaczmarczyk Robert , Rueckert Daniel , Biedermann Tilo , Zink Alexander 
Published: June 2023

SummaryBackgroundDermatological conditions are prevalent across all population sub‐groups. The affected body part is of importance to their diagnosis, therapy, and research. The automatic identification of body parts in dermatological clinical pictures could therefore improve clinical care by providing additional information for clinical decision‐making algorithms, discovering hard‐to‐treat areas, and research by identifying new patterns of disease.Patients and MethodsIn this study, we used 6,219 labelled dermatological images from our clinical database, which were used to train and validate a convolutional neural network. As a use case, qualitative heatmaps for the body part distribution in common dermatological conditions was generated using this system.ResultsThe algorithm reached a mean balanced accuracy of 89% (range 74.8%–96.5%). Non‐melanoma skin cancer photos were mostly of the face and torso, while hotspots of eczema and psoriasis image distribution included the torso, legs, and hands.ConclusionsThe accuracy of this system is comparable to the best to‐date published algorithms for image classification challenges, suggesting this algorithm could boost diagnosis, therapy, and research of dermatological conditions.
Burden of undiagnosed and suboptimally controlled diabetes in selected regions of India: Results from the SMART India population‐level diabetes screening study
Authors: Rajalakshmi Ramachandran , Vasconcelos Joana C. , Prevost A. Toby , Sivaprasad Sobha , Deepa Mohan , Raman Rajiv , Ramasamy Kim , Anjana Ranjit Mohan , Conroy Dolores , Das Taraprasad , Hanif Wasim , Mohan Viswanathan ,   SMART India Study Collaborators
Published: June 2023

AbstractAimsTo estimate the prevalence of undiagnosed diabetes and suboptimally controlled diabetes and the associated risk factors by community screening in India.MethodsIn this multi‐centre, cross‐sectional study, house‐to‐house screening was conducted in people aged ≥40 years in urban and rural areas across 10 states and one union territory in India between November 2018 and March 2020. Participants underwent anthropometry, clinical and biochemical assessments. Capillary random blood glucose and point‐of‐care glycated haemoglobin (HbA1c) were used to diagnose diabetes. The prevalence of undiagnosed diabetes and suboptimal control (HbA1c ≥53 mmol/mol [≥7%]) among those with known diabetes was assessed.ResultsAmong the 42,146 participants screened (22,150 urban, 19,996 rural), 5689 had known diabetes. The age‐standardised prevalence of known diabetes was 13.1% (95% CI 12.8–13.4); 17.2% in urban areas and 9.4% in rural areas. The age‐standardised prevalence of undiagnosed diabetes was 6.0% (95% CI 5.7–6.2); similar in both urban and rural areas with the highest proportions seen in the East (8.0%) and South (7.8%) regions. When we consider all people with diabetes in the population, 22.8% of individuals in urban areas and 36.7% in rural areas had undiagnosed diabetes. Almost 75% of the individuals with known diabetes had suboptimal glycaemic control.ConclusionsHigh prevalence of undiagnosed diabetes and suboptimally controlled diabetes emphasises the urgent need to identify and optimally treat people with diabetes to reduce the burden of diabetes.
Influence of host larval weight of Anastrepha ludens on production parameters and quality attributes in the mass rearing of the parasitoid Diachasmimorpha longicaudata
Authors: Cancino Jorge , Ayala Amanda , López Patricia , de Ma Moreno Flor , Solis Eduardo , Orozco‐Dávila Dina 
Published: June 2023

AbstractLarvae of Anastrepha ludens (Loew) (Diptera: Tephritidae) are non‐native hosts of the parasitoid Diachasmimorpha longicaudata (Ashmead) (Hymenoptera: Braconidae). These hosts appear to be a very good resource for the development of D. longicaudata in a wide range of larval weights. Therefore, the present study aimed to evaluate whether the larval weight of A. ludens influences the emergence and mass‐rearing parameters of D. longicaudata, including the parasitoid's adult attributes and host selection capacity. Three mean larval weights of 29, 25, and 21 mg were considered as high, medium, and low categories for the analysis. The tests included the effect of management of host larvae in the mass rearing of the parasitoids. In addition, evaluations of flight ability, survival, fecundity, and size were carried out in the adults that emerged from the larvae of the various weight categories. There was a direct relationship between host larval weight and parasitoid pupal weight, but there was no relationship with the emergence of adult parasitoids. However, a high percentage of females emerged from heavier larvae. Similarly, although adults that developed in the heaviest larval category were larger, adult quality parameters were not affected. In the evaluations of host selection, the parasitoids oviposited randomly in the larvae from the various weight categories; there was only selection if larvae of different weights were mixed. In addition, superparasitism did not differ between larval weight categories. In the evaluation of competition for hosts in cages under field conditions, larger female parasitoids that developed in the heaviest host larvae landed more frequently on infested fruit, but oviposition was similar between females of different sizes. In conclusion, the larval weight of A. ludens influenced the size of the host puparia and of adults of D. longicaudata, but the emergence and attributes of the developed adults were similar. Therefore, it can be concluded that the low larval weights of A. ludens evaluated in this study are within the range for proper development of D. longicaudata in mass rearing. This allows several options to produce hosts at a lower cost without negatively affecting the quality of parasitoid production.
Surgical outcomes of open and laser interstitial thermal therapy approaches for corpus callosotomy in pediatric epilepsy
Authors: Aum Diane J. , Reynolds Rebecca A. , McEvoy Sean , Tomko Stuart , Zempel John , Roland Jarod L. , Smyth Matthew D. 
Published: June 2023

AbstractObjectiveCorpus callosotomy (CC) is a palliative surgical intervention for patients with medically refractory epilepsy that has evolved in recent years to include a less‐invasive alternative with the use of laser interstitial thermal therapy (LITT). LITT works by heating a stereotactically placed laser fiber to ablative temperatures under real‐time magnetic resonance imaging (MRI) thermometry. This study aims to (1) describe the surgical outcomes of CC in a large cohort of children with medically refractory epilepsy, (2) compare anterior and complete CC, and (3) review LITT as a surgical alternative to open craniotomy for CC.MethodsThis retrospective cohort study included 103 patients <21 years of age with at least 1 year follow‐up at a single institution between 2003 and 2021. Surgical outcomes and the comparative effectiveness of anterior vs complete and open versus LITT surgical approaches were assessed.ResultsCC was the most common surgical disconnection (65%, n = 67) followed by anterior two‐thirds (35%, n = 36), with a portion proceeding to posterior completion (28%, n = 10). The overall surgical complication rate was 6% (n = 6/103). Open craniotomy was the most common approach (87%, n = 90), with LITT used increasingly in recent years (13%, n = 13). Compared to open, LITT had shorter hospital stay (3 days [interquartile range (IQR) 2–5] vs 5 days [IQR 3–7]; p < .05). Modified Engel class I, II, III, and IV outcomes at last follow‐up were 19.8% (n = 17/86), 19.8% (n = 17/86), 40.2% (n = 35/86), and 19.8% (n = 17/86). Of the 70 patients with preoperative drop seizures, 75% resolved postoperatively (n = 52/69).SignificanceNo significant differences in seizure outcome between patients who underwent only anterior CC and complete CC were observed. LITT is a less‐invasive surgical alternative to open craniotomy for CC, associated with similar seizure outcomes, lower blood loss, shorter hospital stays, and lower complication rates, but with longer operative times, when compared with the open craniotomy approach.
Security Analysts’ Site Visits and Stock Price Synchronicity
Authors: Jiang Yu , Lei Adrian C. H. 
Published: June 2023

AbstractThis paper investigates how security analysts’ corporate site visits impact listed firms’ stock‐price informativeness. Examining a sample of security analysts’ visits to Chinese listed firms from 2010 to 2019, we find that security analysts incorporate firm‐specific information into share prices through site visits, significantly reducing the visited firms’ stock price synchronicity. This finding is robust to an alternative measure of stock price informativeness and a two‐stage least‐squares approach using the introduction of high‐speed rail as the instrumental variable. We also find that the impact of analysts’ site visits on firms’ stock price synchronicity is more pronounced for firms with lower information disclosure quality and poor corporate governance than for other firms. Further analysis on firm characteristics documents that this effect is stronger for large‐size firms, firms in the manufacturing industry, and state‐owned enterprises.
Dengue: updates for dermatologists on the world's fastest‐growing vector‐borne disease
Authors: Braun Mitchell , Andersen Louise K. , Norton Scott A. , Coates Sarah J. 
Published: June 2023

AbstractDengue is the world's fastest‐growing vector borne disease and has significant epidemic potential in suitable climates. Recent disease models incorporating climate change scenarios predict geographic expansion across the globe, including parts of the United States and Europe. It will be increasingly important in the next decade for dermatologists to become familiar with dengue, as it commonly manifests with rashes, which can be used to aid diagnosis. In this review, we discuss dengue for general dermatologists, specifically focusing on its cutaneous manifestations, epidemiology, diagnosis, treatment, and prevention. As dengue continues to spread in both endemic and new locations, dermatologists may have a larger role in the timely diagnosis and management of this disease.