bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case study of superelevation design at an expressway interchange by using ADSCivil Road software
Authors: Pham Bach Van , Nguyen Thanh-Binh , Dao Viet-Cuong , Bui Quynh-Anh Thi 
Published: August 2023

Abstract
Superelevation is known as a transverse slope made available to mitigate the impact of centrifugal force and minimize the vehicle’s tendency to overturn and skid. However, in an intersection or interchange that has horizontal curves with small radius consecutively, it is difficult to design superelevation. If the superelevation arrangement is not good enough, the alignment is not smooth, causing unfavourable and unsafe conditions. Moreover, for expressway interchange, it become more complicated to design by manual method because the expressway requirements in term of safety and aesthetics is higher than that of conventional intersection. On the other hand, ADSCivil Road, a software in the ADSCivil solution suite for infrastructure design developed by Baezeni Soft Co, Ltd. is a useful tool for geometric road design. This paper presents the results of ADSCivil Road software application in designing the superelevation at the expressway. ADSCivil Road has arranged superelevation for an interchange ramp (with a design speed of 60 km/h) that includes the small radius circular curves connecting together (R=125 m and R=100 m). The results show that using the superelevation diagram and corridor model in ADSCivil Road makes the superelevation design process more intuitive, make it easier to adjust the slope at each point, and controls the rate of superelevation difference. In addition, ADSCivil Road automatically updates the superelevation change for profile, cross-section and plan. Also, 3D simulation results show that the superelevation layout for this interchange meets technical, economic, and aesthetic requirements. Obviously, it can be seen that can become an effective tool to help engineers solve complex problems in road design.
Adsorption-catalytic method for reducing the content of sulphur compounds in gas condensate diesel fuel
Authors: Grishina Irina , Lyubimenko Valentina , Kolesnikov Sergey , Shcherban Alena , Vinokurov Vladimir 
Published: August 2023

Abstract
Gas condensate diesel fuels, being an excellent resource base, often do not meet modern standards of the cetane number value and the content of sulfur compounds (SC). Currently, Euro 5 and Euro 6 (<10 ppm sulfur content) diesel motor fuels are produced worldwide. High-quality diesel fuels are produced using hydro desulfurization process. Analysis of scientific publications has shown that the adsorption is effective method of desulphurization, which can serve as a method of removing SC from fuels or refining oil and its fractions, which allows removing residual sulfur. The advantages of the adsorption method are: low level of capital costs; simplicity of equipment; carrying out the process under much milder conditions compared to hydro desulfurization. In this paper, an original adsorption-catalytic method of reducing the concentration of SC to <10 ppm using a nanoporous adsorbent-catalyst is proposed. The structure and content of complex sulfur compounds in gas condensate fuels obtained from the raw materials of two deposits – Yamburgsky and Zapolyarny – were determined by gas chromatography–mass spectrometry. The next SC substances were found: tert-hexadecanethiol (C16H34S); 4,4,6-trimethyl-5-phenyl-1,3-oxazinane-2-thione (C13H17NOS); 1,2-bis(2-methylundecan-2-yl)-disulfane (C24H50S2); 3-methyl-2,4a,9,9a-tetrahydro-1H-2λ4-indeno [2,1-c]thiopyran-2-carbonitrile (C14H15NS) and 2,3,4,5-pentamethylbenzene-sulfoneamide (C11H17NO2S). Three-dimensional images of SC molecules and their adsorption complexes with Al-Ni-Mo-O component of a complex adsorbent-catalyst were obtained by molecular modeling. The adsorption energies of SC on the Al-Ni-Mo-O catalyst are calculated. The obtained values of the adsorption energies are in the range of −99.17 ÷−231.66 kJ/mol. As a result of the conducted research, a cartridge with selected adsorbent catalysts has been developed, which must be activated by heating in an inert medium up to 350 ° C. The average life of the cartridge is 1.5 years, after which it needs restoration.
Applications of common energy variability methods for establishing the equilibrium equation in mechanics
Authors: Dao Cong-Binh , Mai Viet-Chinh 
Published: August 2023

Abstract
The principles of the energy variation method are commonly utilized in mechanics. Energy is a scalar variable, so these are more convenient and simple to establish the equilibrium equations compared to vector-based approaches (i.e. using forces and displacements). The present article applied the theorem of the energy variation method in order to set the equilibrium equations for various complicated problems. Four examples of applying the energy variation method include the differential equation of the Euler – Bernoulli beam based on the energy method, the system of Equilibrium Equations of the Euler–Bernoulli beam with the theorem of Least Work, the principle of maximum work to establish the equation of motions for the Euler–Bernoulli beam and the equation of motion for the Euler–Bernoulli beam by the virtual work theorem, have been implemented. The results obtained from this study open up further research directions on the application of the energy variation method in mechanics as well as in the analysis theory of beam bridges.
Utilization of rubber aggregates in cement-treated bases: A review
Authors: Pham Phuong N. 
Published: August 2023

Abstract
Cement-treated bases are commonly used in high-classified road pavements due to their stable strength and improved durability. However, this type of pavement base is sensitive to shrinkage caused by early water loss or temperature change after construction, resulting in shrinkage cracks and subsequent reflective cracking in semi-rigid pavements. To address this issue, various waste or by-products, such as oil, steel slag, end-of-life tires etc., have been investigated for use as an additive or a replacement for aggregates in cement-treated base. This review focuses specifically on the impact of rubber aggregates on the properties of rubberized cement-stabilized aggregates. In general, rubber aggregates are detrimental to the mechanical properties of cement-treated aggregates. However, the rubberized cement-stabilized aggregates exhibited reduced shrinkage and improved shrinkage cracking resistance, as confirmed through actual field applications. Furthermore, internal microstructure analyses indicate that rubberized cement-stabilized aggregates possess excellent anti-cracking capacity, particularly when subjected to compressive loadings. The review ends with recommendations and future studies to promote the applicability of rubberised cement-stabilized bases in semi-rigid pavements.
Strength Performance of Alkali Activated Binder and Cement Stabilized Expansive Soil: A Field Study on Subgrade Layer
Authors: Syed Mazhar , GuhaRay Anasua 
Published: August 2023

Abstract
The dual character of expansive subgrade soil, which includes swelling and shrinkage, causes a premature collapse on the pavement surfaces. The scopes of the current study include comparison of the field performance of cement and alkali activated binder (AAB) stabilized expansive subgrade soil. To assess the strength properties, a 12 m long semi-field test section with expansive soil that has been treated with AAB, cement, and untreated expansive soil is built. Steel slag and fly ash are used as dry pozzolanic precursors in AAB, while sodium silicate and sodium hydroxide are used as an activator solution in a 0.4 water:solids ratio. AAB provides twin benefits of reducing the need for traditional binders and lowering the cost of fly ash/slag disposal in landfills. It also has a less carbon footprint than a PC-based binder, stronger mechanical strength and longer durability. By embedding a number of stress metres and strain gauges in the subgrade layer and applying a load through a dual-wheel truck load (12-tonne rear axle load) on the field track, the in-situ subgrade strength behaviour is assessed. On samples taken from the field section, the effects of AAB, curing duration, and the proportion of steel slag/fly ash in the alkaline soil mixture on the geomechanical properties of soil are examined. Additionally, using KGP-BACK software, falling weight deflectometer investigations were conducted to assess the elastic moduli of each layer. It has been noted that subgrade layers treated with AAB had larger elastic moduli than those treated with cement or left untreated. In comparison to cement-treated soil, the AAB mixture’s subgrade strength is increased by 23-26% by the combined addition of slag and fly ash. Based on the semi-field test section studies, recommendations for the effective application of AAB stabilisation for expansive soils as subgrade are given.
Bearing capacity of strip footing on c-ϕ slope under rainfall condition
Authors: Tran Minh Nhat , Lai Van Qui , Nguyen Trung Kien , Dang Dang Tung , Huynh Ngoc Thi 
Published: August 2023

Abstract
This paper presents a novel solution for predicting the bearing capacity of a strip footing on a c-ϕ (cohesive-frictional) slope under rainfall conditions. The commercial finite element PLAXIS code was adopted for numerical modelling purposes. The bearing capacity of the strip footing is expressed through a dimensionless bearing capacity factor. The bearing capacity was examined considering the rainfall conditions and variation of design parameters, e.g., soil strength parameters, slope angle, and setback ratio. The results show that the bearing capacity of strip footing on the slope decrease under rainfall compares to its normal condition and the effects of each parameter on the UBC. The paper’s results can be a helpful reference for practical engineering in predicting the bearing capacity of strip footing on the c-ϕ slope under rainfall conditions.
Effects of curing temperature on cement-stabilized soils
Authors: Tran Thien Q , Ju Hwanik , Nguyen Tu-Nam , Hoang Tung P , Abdelaziz Sherif L , Brand Alexander S 
Published: August 2023

Abstract
Curing temperature is widely known for its effects on the strength of various cementitious-based civil engineering materials, including in stabilized soils. Curing materials at different temperatures can cause negative or positive impacts on the mechanical properties of these materials due to the effect of temperature on hydration behavior, hydration rate, and ion exchange. This paper aims to better understand these factors in geoengineering applications. In particular, the discussion focuses on the effects of curing temperatures ranging from below freezing to 50 °C on the hydration process of cement paste (i.e., hydration rate, mineral dissolution, compressive strength) and the hydration process and strengthening mechanism of cement-stabilized soils. Finally, an informative table listing the advantages and disadvantages of the influences of each temperature level on these materials is provided as a summary of the findings from the literature.
Pregnancy-specific alcohol policies and admissions to substance use disorder treatment for pregnant people in the USA
Authors: Berglas Nancy F , Subbaraman Meenakshi S , Thomas Sue , Roberts Sarah C M 
Published: August 2023

AbstractAimsWe examined relationships between pregnancy-specific alcohol policies and admissions to substance use disorder treatment for pregnant people in the USA.MethodsWe merged state-level policy and treatment admissions data for 1992–2019. We aggregated data by state-year to examine effects of nine pregnancy-specific alcohol policies on the number of admissions of pregnant women where alcohol was reported as the primary, secondary, or tertiary substance related to the treatment episode (N = 1331). We fit Poisson models that included all policy variables, state-level controls, fixed effects for state and year, state-specific time trends, and an offset variable of the number of pregnancies in the state-year to account for differences in population size and fertility.ResultsWhen alcohol was reported as the primary substance, civil commitment [incidence rate ratio (IRR) 1.45, 95% CI: 1.10–1.89] and reporting requirements for assessment and treatment purposes [IRR 1.36, 95% CI: 1.04–1.77] were associated with greater treatment admissions. Findings for alcohol as primary, secondary, or tertiary substance were similar for civil commitment [IRR 1.31, 95% CI: 1.08–1.59] and reporting requirements for assessment and treatment purposes [IRR 1.21, 95% CI: 1.00–1.47], although mandatory warning signs [IRR 0.84, 95% CI: 0.72–0.98] and priority treatment for pregnant women [IRR 0.88, 95% CI: 0.78–0.99] were associated with fewer treatment admissions. Priority treatment findings were not robust in sensitivity analyses. No other policies were associated with treatment admissions.ConclusionsPregnancy-specific alcohol policies related to greater treatment admissions tend to mandate treatment rather than make voluntary treatment more accessible, raising questions of ethics and effectiveness.
According to law
Authors: Perry Adam 
Published: August 2023

Abstract
Legal discourse consists largely of legal claims. These are claims that there is a legal obligation, legal right, or other legal incident. What is the meaning of “legal obligation”, “legal right” and so on in legal claims? The standard view among philosophers of law is that “legal” indicates that, according to law, there is a moral obligation, moral right or other moral incident. Here I set out a new objection to the standard view. The objection is that the standard view is unable to account for the use of legal claims in some common forms of logically complex arguments.
A new paradox for well-being subjectivism
Authors: Davies Ben 
Published: August 2023

Abstract
Subjectivists think that our well-being is grounded in our subjective attitudes. Many such views are vulnerable to variations on the ‘paradox of desire’, where theories cannot make determinate judgements about the well-being of agents who take a positive valuing attitude towards their life going badly. However, this paradox does not affect all subjectivist theories; theories grounded on agents’ prudential values can avoid it.
This paper suggests a new paradox for subjectivist theories which has a wider scope, and includes such prudential judgement theories. I outline the new paradox and show how two plausible idealisztions (coherence and consideration) will not help. Subjectivists about well-being must either add an additional idealization that can solve the paradox of judgement or explain why such paradoxes do not constitute serious objections to a theory of well-being.
God, gluts and evil
Authors: Beall Jc 
Published: August 2023

Abstract
The aim of this paper is to advance a very natural and very simple glut-theoretic response to the problem of evil – or at least the target, ‘logical’ problem of evil. At the very least, the given account rebuts the frequent claim – even by glut theorists (including me until recently) – that gluts are entirely irrelevant to the problem of evil even if otherwise involved in the true theology.
Genomic signatures of ecological divergence between savanna and forest populations of a Neotropical tree
Authors: Muniz André Carneiro , de Oliveira Buzatti Renata Santiago , de Lemos-Filho José Pires , Heuertz Myriam , Nazareno Alison Gonçalves , Lovato Maria Bernadete 
Published: August 2023

AbstractBackground and AimsIn eastern Neotropical South America, the Cerrado, a large savanna vegetation, and the Atlantic Forest harbour high biodiversity levels, and their habitats are rather different from each other. The biomes have intrinsic evolutionary relationships, with high lineage exchange that can be attributed, in part, to a large contact zone between them. The genomic study of ecotypes, i.e. populations adapted to divergent habitats, can be a model to study the genomic signatures of ecological divergence. Here, we investigated two ecotypes of the tree Plathymenia reticulata, one from the Cerrado and the other from the Atlantic Forest, which have a hybrid zone in the ecotonal zone of Atlantic Forest–Cerrado.MethodsThe ecotypes were sampled in the two biomes and their ecotone. The evolutionary history of the divergence of the species was analysed with double-digest restriction site-associated DNA sequencing. The genetic structure and the genotypic composition of the hybrid zone were determined. Genotype-association analyses were performed, and the loci under putative selection and their functions were investigated.Key ResultsHigh divergence between the two ecotypes was found, and only early-generation hybrids were found in the hybrid zone, suggesting a partial reproductive barrier. Ancient introgression between the Cerrado and Atlantic Forest was not detected. The soil and climate were associated with genetic divergence in Plathymenia ecotypes and outlier loci were found to be associated with the stress response, with stomatal and root development and with reproduction.ConclusionsThe high genomic, ecological and morphophysiological divergence between ecotypes, coupled with partial reproductive isolation, indicate that the ecotypes represent two species and should be managed as different evolutionary lineages. We advise that the forest species should be re-evaluated and restated as vulnerable. Our results provide insights into the genomic mechanisms underlying the diversification of species across savanna and forest habitats and the evolutionary forces acting in the species diversification in the Neotropics.
Cell-connectivity-guided trajectory inference from single-cell data
Authors: Smolander Johannes , Junttila Sini , Elo Laura L 
Published: August 2023

Abstract

Motivation
Single-cell RNA-sequencing enables cell-level investigation of cell differentiation, which can be modelled using trajectory inference methods. While tremendous effort has been put into designing these methods, inferring accurate trajectories automatically remains difficult. Therefore, the standard approach involves testing different trajectory inference methods and picking the trajectory giving the most biologically sensible model. As the default parameters are often suboptimal, their tuning requires methodological expertise.

Results
We introduce Totem, an open-source, easy-to-use R package designed to facilitate inference of tree-shaped trajectories from single-cell data. Totem generates a large number of clustering results, estimates their topologies as minimum spanning trees, and uses them to measure the connectivity of the cells. Besides automatic selection of an appropriate trajectory, cell connectivity enables to visually pinpoint branching points and milestones relevant to the trajectory. Furthermore, testing different trajectories with Totem is fast, easy, and does not require in-depth methodological knowledge.

Availability and implementation
Totem is available as an R package at https://github.com/elolab/Totem.
O09 Long-term safety of ustekinumab in paediatric patients with moderate-to-severe plaque psoriasis: results from an ongoing observational study
Authors: Mahé Emmanuel , Geldhof Anja , Movshovich Evgenia , Schreiber Joerg , Malynn Sandra , Efficace Michela , Seyger Marieke M B 
Published: August 2023

Abstract
The European Medicines Agency approved ustekinumab for psoriasis treatment in adolescents (12–17 years) in 2015 (CADMUS trial), and children (6–11 years) in 2020. Interim results are reported from a post-authorization study (NCT03218488) evaluating the long-term safety profile of ustekinumab. This ongoing, prospective, observational, multicentre study enrolled patients (6–17 years) diagnosed with moderate-to-severe plaque psoriasis initiating ustekinumab. Clinical data and all adverse events (AEs) through approximately 54 months (data cut-off) are reported. Younger children (6–11 years) were included later in the study. Data are reported by age (younger cohort, 6–11; older cohort, 12–17). At data cut-off, 85 patients, 10 younger (median follow-up, 0.24 years) and 75 older (median follow-up, 1.69 years), had been enrolled. Ustekinumab therapy was discontinued in 11 (12.9%) patients, all from the older cohort. Overall, 50/85 (58.8%) patients reported 290 AEs and 27 (31.8%) reported 96 AEs considered related to ustekinumab. The most commonly reported AEs were nasopharyngitis (n = 8, 9.4%), fatigue (n = 7, 8.2%) and headache (n = 7, 8.2%). Most AEs were mild and did not result in treatment change. Nine (10.6%) patients reported 13 serious AEs; one (appendicitis) was considered related to ustekinumab. One younger patient reported two AEs considered related to ustekinumab, although neither was serious and therapy continued. No malignancies or deaths were reported in either cohort. These findings revealed no new safety concerns and are generally consistent with the known safety profile for ustekinumab in paediatric patients.
Increased dental comorbidities in patients with psoriasis: a nationwide population-based cohort study in Korea
Authors: Kwak Eun-Jung , Choi Yun Jin , Kim Han-Na , Kim Ko Eun , Jeon Jiehyun , Baek Yoo Sang 
Published: August 2023

Abstract

Background
Limited data are available regarding the association between psoriasis and common dental conditions.

Objectives
To investigate the risk of potential dental comorbidities in patients with psoriasis.

Methods
We conducted a nationwide population-based cohort study to analyse the claims data of patients with psoriasis (n = 15 165) and age- and sex-matched controls (n = 75 825). The incidence risk of the following potential dental conditions was analysed: dental caries, pulp and periapical disease, periodontal disease, gingival changes and tooth loss.

Results
After adjusting for potential cofactors, the adjusted hazard ratios (aHRs) of dental caries [1.105; 95% confidence interval (CI) 1.078–1.132], pulp and periapical disease (1.07; 95% CI 1.044–1.096) and periodontal disease (1.108; 95% CI 1.088–1.129) were significantly higher than those in the control cohort (P &lt; 0.001). However, among the subset of patients with psoriasis who received systemic antipsoriatic treatment (n = 4275), the aHR risk of all potential dental comorbidities was not significantly higher from that of the control cohort.

Conclusions
Patients with psoriasis have an increased risk of dental comorbidities, and systemic antipsoriatic treatment may help mitigate this increased risk.
MAIT cells in bacterial infectious diseases: heroes, villains, or both?
Authors: Wu Sihong , Yang Xi , Lou Yongliang , Xiao Xingxing 
Published: August 2023

Abstract
Due to the aggravation of bacterial drug resistance and the lag in the development of new antibiotics, it is crucial to develop novel therapeutic regimens for bacterial infectious diseases. Currently, immunotherapy is a promising regimen for the treatment of infectious diseases. Mucosal-associated invariant T (MAIT) cells, a subpopulation of innate-like T cells, are abundant in humans and can mount a rapid immune response to pathogens, thus becoming a potential target of immunotherapy for infectious diseases. At the site of infection, activated MAIT cells perform complex biological functions by secreting a variety of cytokines and cytotoxic substances. Many studies have shown that MAIT cells have immunoprotective effects because they can bridge innate and adaptive immune responses, leading to bacterial clearance, tissue repair, and homeostasis maintenance. MAIT cells also participate in cytokine storm generation, tissue fibrosis, and cancer progression, indicating that they play a role in immunopathology. In this article, we review recent studies of MAIT cells, discuss their dual roles in bacterial infectious diseases and provide some promising MAIT cell-targeting strategies for the treatment of bacterial infectious diseases.