bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Changes in Surgical Outcomes for Patients With Inflammatory Bowel Disease Following Medicaid Expansion
Authors: Tong Jason K C , Mascuilli Tory , Wirtalla Christopher , Aarons Cary B , Saur Nicole M , Mahmoud Najjia N , Karakousis Giorgos C , Kelz Rachel R 
Published: December 2022

Abstract

Background
Little is known about the impact of Medicaid expansion on the surgical care of inflammatory bowel disease. We sought to determine whether Medicaid expansion is associated with improved postsurgical outcomes for patients with inflammatory bowel disease undergoing a colorectal resection.

Methods
We performed a risk-adjusted difference-in-difference study examining postsurgical outcomes for patients ages 26 to 64 with Crohn’s disease or ulcerative colitis undergoing a colorectal resection across 15 states that did and did not expand Medicaid before (2012-2013) and after (2016-2018) policy reform. Primary study outcomes included 30-day readmission and postoperative complication.

Results
Study population included 11 394 patients with inflammatory bowel disease that underwent a colorectal resection. States that underwent Medicaid expansion were associated with a rise in Medicaid enrollment following policy reform (11.8% pre-Medicaid expansion vs 19.7% post-Medicaid expansion). Difference-in-difference analysis revealed a statistically significant lower odds of 30-day readmission in patients undergoing a colorectal resection in expansion states following policy reform relative to patients in nonexpansion states prior to reform (odds ratio, 0.56; 95% confidence interval, 0.36-0.86). No changes in odds of postoperative complication were noted across expansion and nonexpansion states.

Conclusions
Medicaid expansion is associated with a rise in Medicaid enrollment in expansion states following policy reform. There were greater improvements in postoperative outcomes associated with patients in expansion states following policy reform relative to patients in nonexpansion states prior to reform, which may have been related to improved perioperative care and medical management.
A kidney proximal tubule model to evaluate effects of basement membrane stiffening on renal tubular epithelial cells
Authors: Wang Dan , Sant Snehal , Lawless Craig , Ferrell Nicholas 
Published: December 2022

Abstract
The kidney tubule consists of a single layer of epithelial cells supported by the tubular basement membrane (TBM), a thin layer of specialized extracellular matrix (ECM). The mechanical properties of the ECM are important for regulating a wide range of cell functions including proliferation, differentiation and cell survival. Increased ECM stiffness plays a role in promoting multiple pathological conditions including cancer, fibrosis and heart disease. How changes in TBM mechanics regulate tubular epithelial cell behavior is not fully understood. Here we introduce a cell culture system that utilizes in vivo-derived TBM to investigate cell–matrix interactions in kidney proximal tubule cells. Basement membrane mechanics was controlled using genipin, a biocompatibility crosslinker. Genipin modification resulted in a dose-dependent increase in matrix stiffness. Crosslinking had a marginal but statistically significant impact on the diffusive molecular transport properties of the TBM, likely due to a reduction in pore size. Both native and genipin-modified TBM substrates supported tubular epithelial cell growth. Cells were able to attach and proliferate to form confluent monolayers. Tubular epithelial cells polarized and assembled organized cell–cell junctions. Genipin modification had minimal impact on cell viability and proliferation. Genipin stiffened TBM increased gene expression of pro-fibrotic cytokines and altered gene expression for N-cadherin, a proximal tubular epithelial specific cell–cell junction marker. This work introduces a new cell culture model for cell-basement membrane mechanobiology studies that utilizes in vivo-derived basement membrane. We also demonstrate that TBM stiffening affects tubular epithelial cell function through altered gene expression of cell-specific differentiation markers and induced increased expression of pro-fibrotic growth factors.
Comparison of Commercial Low Molecular Weight Heparin and Homemade Anti-Xa Calibrators to a Commercial Specific Anti-Xa Calibrator for Plasma Rivaroxaban Quantification by Anti-Xa Oral Anticoagulant Plasma Concentration Chromogenic Assay
Authors: Divsalar Bita , Kalantari Tahereh , Mohebbi Soheila , Bahmanimehr Ardeshir , Shahsavani Amin , Borhani-Haghighi Afshin 
Published: December 2022

Abstract

Objective
The main concern about measuring the concentration of rivaroxaban by anti-Xa assay in some laboratories is the lack of a commercial specific calibrator in emergencies. Therefore, this study aimed at providing a homemade anti-Xa calibrator and commercial low molecular weight heparin (LMWH) anti-Xa calibrator.

Methods
The anti-Xa plasma concentration of rivaroxaban was measured in 70 patients using a commercial specific anti-Xa calibrator, a commercial LMWH anti-Xa calibrator, and a homemade anti-Xa calibrator.

Results
We demonstrated a significant correlation and agreement (P &lt; .001) between LMWH-calibrated anti-Xa and the commercial specific calibrator. A significant correlation (P &lt; .001) was found between homemade calibrated anti-Xa made by normal pooled plasma and that calibrated with a commercial specific drug. The nonspecific homemade and LMWH calibrators had excellent agreement (P &lt; .001) and can be used interchangeably.

Conclusion
Our data showed that for estimating rivaroxaban concentrations, the LMWH calibrator could be used as an alternative calibrator in the anti-Xa assay.
Notional Spread of Cholera in Haiti Following a Natural Disaster: Considerations for Military and Disaster Relief Personnel
Authors: Hadeed Steven J , Broadway Katherine M , Schwartz-Watjen Kierstyn T , Tigabu Bersabeh , Woodards Ashley J , Swiatecka Anna L , Owens Akeisha N , Wu Aiguo 
Published: December 2022

ABSTRACT

Introduction
Cholera remains a significant public health threat for many countries, and the severity largely varies by the population and local conditions that drive disease spread, especially in endemic areas prone to natural disasters and flooding. Epidemiological models can provide useful information to military planners for understanding disease spread within populations and the effectiveness of response options for preventing the transmission among deployed and stationed personnel. This study demonstrates the use of epidemiological modeling to understand the dynamics of cholera transmission to inform emergency planning and military preparedness in areas with highly communicable diseases.

Materials and Methods
Areas with higher probability for a potential cholera outbreak in Haiti followed by a natural disaster were identified. The hotspots were then used to seed an extended compartmental model, EpiGrid, to simulate notional spread scenarios of cholera originating in three distinct areas in Haiti. Disease parameters were derived from the 2010 cholera outbreak in Haiti, and disease spread was simulated over a 12-week period under uncontrolled and controlled spread.

Results
For each model location, scenarios of mitigated (intervention with 30% transmission reduction via international aid) and unmitigated (without intervention) are simulated. The results depict the geographical spread and estimate the cumulative cholera infection for each notional scenario over the course of 3 months. Disease transmission differs considerably across origin site with an outbreak originating in the department of Nippes spanning the largest geographic area and resulting in the largest number of cumulative cases after 12 weeks under unmitigated (79,518 cases) and mitigated (35,667 cases) spread scenarios.

Conclusions
We modeled the notional re-emergence and spread of cholera following the August 2021 earthquake in Haiti while in the midst of the global COVID-19 pandemic. This information can help guide military and emergency response decision-making during an infectious disease outbreak and considerations for protecting military personnel in the midst of a humanitarian response. Military planners should consider the use of epidemiological models to assess the health risk posed to deployed and stationed personnel in high-risk areas.
Behaviours of disco-seismological c-mode oscillations around the inner edge of discs
Authors: Kato Shoji 
Published: December 2022

ABSTRACT
Accretion flows in the innermost region of relativistic discs are transonic. At the transonic radius, the differential equation describing wave motions with constant frequency becomes singular. This implies that for an oscillation of constant frequency to be realized in the innermost region of discs, the oscillation needs to satisfy some regularity conditions (boundary conditions) at the sonic radius. In this paper, under the assumption that the unperturbed disc structure around the sonic radius is rather smooth in the radial direction, behaviours of the fourth-order ordinary differential equation describing non-axisymmetric c-mode oscillations are examined around the sonic radius. Among four linearly independent wave solutions, one is always singular at the sonic radius and is outside of our interest. In remaining three wave modes satisfying boundary conditions, the advection term in equation of motion is a main contributor in determining the structure of the oscillations. Due to this, the waves are tightly wound or change their amplitude sharply in a narrow region around the sonic radius. This characteristic is especially notable in one of three wave modes. Possibility of the oscillations being swallowed into the central source with no reflection at the sonic radius is briefly discussed.
Reconstructing the genesis of a globular cluster system at a look-back time of 9.1 Gyr with the JWST
Authors: Forbes Duncan A , Romanowsky Aaron J 
Published: December 2022

ABSTRACT
Using early-release data from the JWST, Mowla et al. and Claeyssens et al. recently measured various properties for gravitationally lensed compact sources (‘sparkles’) around the ‘Sparkler’ galaxy at a redshift of 1.378 (a look-back time of 9.1 Gyr). Here, we focus on the Mowla et al. as they were able to break the age-metallicity degeneracy and derive independent ages, metallicities, and extinctions for each source. They identified five metal-rich, old Globular cluster (GC) candidates (with formation ages up to ∼13 Gyr). We examine the age–metallicity relation (AMR) for the GC candidates and other Sparkler compact sources. The Sparkler galaxy, which has a current estimated stellar mass of 109 M⊙, is compared to the Large Magellanic Cloud (LMC), the disrupted dwarf galaxy Gaia–Enceladus and the Milky Way (MW). The Sparkler galaxy appears to have undergone very rapid chemical enrichment in the first few hundred Myr after formation, with its GC candidates similar to those of the MW’s metal-rich subpopulation. We also compare the Sparkler to theoretical AMRs and formation ages from the E-MOSAICS simulation, finding the early formation age of its GCs to be in some tension with these predictions for MW-like galaxies. The metallicity of the Sparkler’s star-forming regions are more akin to a galaxy of stellar mass ≥ 1010.5 M⊙, that is, at the top end of the expected mass growth over 9.1 Gyr of cosmic time. We conclude that the Sparkler galaxy may represent a progenitor of a MW-like galaxy, even including the ongoing accretion of a satellite galaxy.
Cigarette Gifting Among Nonsmokers in China: Findings From the International Tobacco Control China Survey
Authors: Lyu Joanne Chen , Sung Hai-Yen , Yao Tingting , Jiang Nan , Quah Anne C K , Meng Gang , Jiang Yuan , Fong Geoffrey T , Max Wendy 
Published: December 2022

AbstractIntroductionCigarette gifting is commonly practiced in China and has contributed to the social acceptability and high prevalence of cigarette smoking in the country. As a result, nonsmokers in China are particularly susceptible to smoking. While previous studies have examined cigarette gifting behaviors among smokers, little is known about cigarette gifting among nonsmokers.Aims and MethodsThis study aimed to examine the percentage and correlates of giving and receiving cigarettes as gifts among adult nonsmokers in China. We analyzed nonsmokers (N = 1813) aged ≥18 years using data from the International Tobacco Control China Wave 5 Survey. Descriptive statistics summarized the characteristics of those who gave and received cigarettes as gifts. Multivariable logistic regression models were used to identify factors associated with the two behaviors.ResultsAmong nonsmokers, 9.9% reported giving cigarettes as gifts to family or friends in the last 6 months. A higher level of knowledge about smoking harms was associated with lower adjusted odds of gifting cigarettes. Nonsmokers aged 25–39 years, with middle income, positive attitude toward cigarette gifts, exposure to anti-smoking information, and exposure to smoking promotion, and those who reported receiving cigarettes as gifts from family or friends were more likely to give cigarettes as gifts. A total of 6.6% of nonsmokers reported receiving cigarettes as gifts in the last 6 months. High education, neutral or positive attitude toward cigarette gifts, exposure to anti-smoking information, exposure to smoking promotion, and having smoking friends were associated with receiving cigarettes as gifts.ConclusionsIt is concerning that Chinese cultural norms that support cigarette gifting have extended to giving nonsmokers cigarettes as gifts. Effective anti-smoking messages are needed. Changing the norms around cigarette gifting and increasing knowledge about smoking harms should help reduce cigarette gifting among nonsmokers.ImplicationsEasy access to cigarettes received as gifts, along with the wide acceptance of smoking in China, places Chinese nonsmokers in a risky position. More educational campaigns targeting nonsmokers to proactively prevent them from smoking are called for. The ineffectiveness of existing anti-smoking information highlights the need for more effective anti-smoking messages. That attitude toward cigarette gifts is the strongest predictor of giving cigarettes as gifts suggests the need for interventions to reverse the positive attitude about cigarette gifting to decrease the popularity of this activity.
Medical management of gastro-esophageal reflux in healthy infants
Authors: Chevalier Isabelle , Beck Carolyn E , Doré-Bergeron Marie-Joëlle , Orkin Julia 
Published: December 2022

Abstract
Clinical symptoms attributed to gastro-esophageal reflux disease (GERD) in healthy term infants are non-specific and overlap with age-appropriate behaviours. This practice point reviews the evidence for medically recommended management of this common condition. Current recommendations to manage GERD include feeding modifications such as thickening feeds or avoiding cow’s milk protein. There is limited evidence for pharmacological management, including acid suppressive therapy or prokinetic agents, with the risks of such treatments often outweighing possible benefits due to significant safety and side effect concerns. Acid-suppressive therapy should not be routinely used for infants with GERD and is most likely to be useful in the context of symptoms that suggest erosive esophagitis. Evidence for managing symptoms attributed to GERD in otherwise healthy term infants less than 1 year of age is presented, and the over-prescription of medications in this population is discouraged. Anticipatory guidance regarding the natural resolution of reflux symptoms is recommended.
La prise en charge médicale du reflux gastro-œsophagien chez les nourrissons en santé
Authors: Chevalier Isabelle , Beck Carolyn E , Doré-Bergeron Marie-Joëlle , Orkin Julia 
Published: December 2022

Abstract
Les symptômes cliniques attribués au reflux gastro-œsophagien pathologique chez les nourrissons nés à terme et en santé sont non spécifiques et rappellent des comportements adaptés à l’âge. Le présent point de pratique analyse les données probantes sur la prise en charge médicale recommandée de cette affection courante. Les recommandations à jour en vue de la prise en charge de ce type de reflux comprennent les modifications à l’alimentation, telles que l’épaississement des aliments ou l’évitement des protéines du lait de vache. Les données probantes à l’égard d’une prise en charge pharmacologique, y compris les traitements antiacides ou les agents procinétiques, sont limitées et démontrent que leurs risques sont souvent supérieurs à leurs éventuels avantages en raison des importantes préoccupations liées à l’innocuité et aux effets secondaires. Les traitements antiacides ne doivent pas être utilisés systématiquement chez les nourrissons présentant un reflux gastro-œsophagien pathologique. Ils sont plus susceptibles d’être utiles pour soigner des symptômes évocateurs d’une œsophagite érosive. Les données probantes sur la prise en charge des symptômes attribués à ce type de reflux chez les nourrissons de moins d’un an qui sont nés à terme et sont autrement en santé sont exposées, et la surprescription de médicaments est déconseillée dans cette population. Les conseils préventifs sur la résolution naturelle des symptômes de reflux sont recommandés.
Canonical ensemble of many fermions in harmonic oscillator potentials: deformation and the liquid drop model
Authors: Sato Hiroshi 
Published: December 2022

Abstract
The thermodynamic quantities of a many-fermion system at low excitation energy are studied in terms of the temperature-dependent antisymmetrized density matrices in spherical and spheroidally deformed harmonic oscillator potentials at quite low temperature. The internal energies of the canonical ensemble of many fermions coincide numerically with those of microcanonical ensemble in the same spherical HO potentials. The saturation properties of binding energy per fermion are found partly as effects of deformation. The relationship between this treatment and the liquid drop model is studied. The characteristic feature of the liquid drop model is found to be not inconsistent with this treatment.
Efficacy of Whole Cancer Stem Cell-Based Vaccines: A Systematic Review of Preclinical and Clinical Studies
Authors: Hashemi Farideh , Razmi Mahdieh , Tajik Fatemeh , Zöller Margot , Dehghan Manshadi Masoumeh , Mahdavinezhad Forough , Tiyuri Amir , Ghods Roya , Madjd Zahra 
Published: December 2022

AbstractBackgroundDespite the conventional cancer therapeutic, cancer treatment remains a medical challenge due to neoplasm metastasis and cancer recurrence; therefore, new approaches promoting therapeutic strategies are highly desirable. As a new therapy, the use of whole neoplastic stem cells or cancer stem cell (CSC)-based vaccines is one strategy to overcome these obstacles. We investigated the effects of whole CSC-based vaccines on the solid tumor development, metastasis, and survival rate.MethodsPrimary electronic databases (PubMed/MEDLINE, Scopus, Embase, and Web of Science) and a major clinical registry were searched. Interventional studies of whole CSC-based vaccines in rodent cancer models (38 studies) and human cancer patients (11 studies) were included; the vaccine preparation methodologies, effects, and overall outcomes were evaluated.ResultsPreclinical studies were divided into 4 groups: CSC-lysates/ inactivated-CSC-based vaccines, CSC-lysate-loaded dendritic cell (CSC-DC) vaccines, cytotoxic T-cell (CTL) vaccines generated with CSC-DC (CSC-DC-CTL), and combinatorial treatments carried out in the prophylactic and therapeutic experimental models. The majority of preclinical studies reported a promising effect on tumor growth, survival rate, and metastasis. Moreover, whole CSC-based vaccines induced several antitumor immune responses. A small number of clinical investigations suggested that the whole CSC-based vaccine treatment is beneficial; however, further research is required.ConclusionsThis comprehensive review provides an overview of the available methods for assessing the efficacy of whole CSC-based vaccines on tumor development, metastasis, and survival rate. In addition, it presents a set of recommendations for designing high-quality clinical studies that may allow to determine the efficacy of whole CSC-based-vaccines in cancer therapy.
Lung cancer screening in primary care
Authors: Peterson Ashley 
Published: December 2022

ABSTRACT
This article reviews the evidence supporting low-dose CT to screen for lung cancer, and the risks, costs, and challenges of implementing broad-based screening for eligible patients. Increased familiarity with lung cancer screening guidelines by primary care and specialty clinicians presents an opportunity to improve lung cancer screening rates and to save lives from the most common cause of cancer death in the United States.
Treating pain using acupuncture for nonacupuncturists
Authors: Toney Bernard 
Published: December 2022

ABSTRACT
Battlefield acupuncture is a specific auricular acupuncture protocol that can be performed by nonacupuncturists in military and civilian clinical settings. Battlefield acupuncture is purported to be efficacious in controlling pain, is quickly administered, and requires minimal postadministration observation. With very low risk and a negligible adverse reaction profile, this technique can be used as an alternative or complement to manage pain. More large randomized controlled trials are needed to compare acupuncture with standard therapy in military and civilian settings.
Endometrial cancer and obesity
Authors: King Lacey , Gajarawala Shilpa , McCrary Melissa D. 
Published: December 2022

ABSTRACT
Endometrial cancer is the most common malignancy of the female reproductive system diagnosed in the United States. The most commonly cited cause is unopposed endogenous estrogen produced by excess adipose tissue. Endometrial cancer typically is diagnosed in postmenopausal women with a body mass index (BMI) of 25 kg/m2 or more. This article reviews how clinicians can use a systematic approach to fill the awkward silence when talking with patients about weight. Meaningful conversations about weight loss can be achieved using the 5 A's for obesity management with the goal of decreasing diagnosis and increasing survivorship from endometrial cancer.
HIPAA and video recordings in the clinical setting
Authors: Miles Gayla , Quinlan Anne 
Published: December 2022

Abstract:
The advent of cellular network technology has increased the use of photography in the clinical setting. This article reviews several areas regarding protected health information (PHI) and the use of video: the 1996 Health Insurance Portability and Accountability Act (HIPAA); The Joint Commission requirements for the use of images; areas of concern for exchanging PHI with law enforcement at the bedside, and the need for the development of formal guidelines regarding the use of video in the clinical setting.