bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombus migration in patients with acute ischaemic stroke undergoing endovascular thrombectomy
Authors: Tan ZeFeng , Zhang Lei , Huang Li'an , Qiao Hongyu , Guan Min , Yang Bing , Yang Pengfei , Zhang Yongwei , Shen Hongjian , Zhou Yu , Hong Bo , Shi Huaizhang , Han Hongxing , Leng Xinyi , Dong Yi , Lian Changlin , Chen Wenhuo , Xu Anding , Liu Jianmin 
Published: June 2023

ObjectiveThe impact of thrombus migration (TM) prior to endovascular thrombectomy (EVT) on clinical outcomes and revascularisation rates remains unknown. We aimed to examine whether preinterventional TM modifies the treatment effects of direct EVT versus bridging EVT in acute large vessel occlusion patients.MethodsAll patients undergoing catheter angiography in the Direct Intra-arterial thrombectomy in order to Revascularise acute ischaemic stroke patients with large vessel occlusion Efficiently in Chinese Tertiary hospitals: A Multicentre randomised clinical Trial were included. TM was determined by radiologists unaware of the study by analysing discrepancies between computed tomographic angiography at baseline and first-run digital subtraction angiography before EVT. The primary outcome was the score on the modified Rankin scale (mRS) assessed at 90 days.ResultsOf 627 included patients, the TM rate was 11.3% (71/627). In the multivariable logistic regression model, baseline National Institutes of Health Stroke Scale score (adjusted OR 0.956, 95% CI 0.916 to 0.999; p=0.043) and intravenous thrombolysis (adjusted OR 2.614, 95% CI 1.514 to 4.514; p<0.001) were independently associated with TM. The patients with TM were less likely to be completely recanalised than those without TM (21.27% vs 36.23%, p=0.040). The interaction of TM and the EVT treatment effect did not significantly affect mRS shift analysis (p=0.687) or mRS scores of 0 to 1 (p=0.436).ConclusionPreinterventional TM does not modify the treatment effects of direct versus bridging EVT on functional outcomes in patients with acute ischaemic stroke with anterior large vessel occlusion. TM leads to a lower complete recanalisation rate.Trial registration number
First time-resolved measurement of infrared scintillation light in gaseous xenon
Authors: Piotter Mona , Cichon Dominick , Hammann Robert , Jörg Florian , Hötzsch Luisa , Marrodán Undagoitia Teresa 
Published: June 2023

AbstractXenon is a widely used detector target material due to its excellent scintillation properties in the ultraviolet (UV) spectrum. The additional use of infrared (IR) scintillation light could improve future detectors. However, a comprehensive characterization of the IR component is necessary to explore its potential. We report on the first measurement of the time profile of the IR scintillation response of gaseous xenon. Our setup consists of a gaseous xenon target irradiated by an alpha particle source and is instrumented with one IR- and two UV-sensitive photomultiplier tubes. Thereby, it enables IR timing measurements with nanosecond resolution and simultaneous measurement of UV and IR signals. We find that the IR light yield is in the same order of magnitude as the UV yield. We observe that the IR pulses can be described by a fast and a slow component and demonstrate that the size of the slow component decreases with increasing levels of impurities in the gas. Moreover, we study the IR emission as a function of pressure. These findings confirm earlier observations and advance our understanding of the IR scintillation response of gaseous xenon, which could have implications for the development of novel xenon-based detectors.
An alternate left-right symmetric model with Dirac neutrinos
Authors: Maharathy Siddharth P. , Mitra Manimala , Sarkar Agnivo 
Published: June 2023

AbstractWe study a different variant of left-right symmetric model, incorporating Dirac type neutrinos. In the absence of the bi-doublet scalars, the possibility of a universal seesaw type of mass generation mechanism for all the Standard Model charged fermions have been discussed. The model has been constructed by extending the Standard Model particle spectrum with heavy vector-like fermions as well as different scalar multiplets. We have shown that this model can generate non zero neutrino mass through loop mediated processes. The parameters which are involved in neutrino mass generation mechanism can satisfy the neutrino oscillation data for both normal and inverted hierarchy. The lightest charged Higgs plays a crucial role in neutrino mass generation mechanism and can have mass of $${\mathcal {O}}[\text {GeV}].$$

O
[
GeV
]
.

We have systematically studied different constraints which are relevant for the charged Higgs phenomenology. In addition to that we also briefly discuss discovery prospects of the charged Higgs at different colliders.
Dynamical equivalence of the varying G and $$\varLambda $$ cosmology with the Brans–Dicke theory
Authors: Paliathanasis A. 
Published: June 2023

AbstractWe investigate the dynamical equivalence of the varying G and $$\varLambda $$
Λ
cosmology with the Brans–Dicke theory. We show that there exist a point transformation which connects the field equations for a spatially flat FLRW geometry. We conclude that the two theories share the same integrability properties and solution trajectories.
Angular momentum and NMR: A brief note
Authors: Burra G. S. 
Published: June 2023

Using noncommutative infinitesimal rotations, we work out a formulation for angular momentum which leads to an expression for nuclear magnetic resonance (NMR). We also indicate a cosmic footprint of these considerations, much like the 21 cm radio signal of cosmic Hydrogen. Here, the motivation is that there are a number of “second-order effects” which provide results over and above the usual well-known results.
Alpha-1 Adrenergic Antagonists Sensitize Neuroblastoma to Therapeutic Differentiation
Authors: Broso Francesca , Gatto Pamela , Sidarovich Viktoryia , Ambrosini Chiara , De Sanctis Veronica , Bertorelli Roberto , Zaccheroni Elena , Ricci Benedetta , Destefanis Eliana , Longhi Sara , Sebastiani Enrico , Tebaldi Toma , Adami Valentina , Quattrone Alessandro 
Published: June 2023

Abstract

Neuroblastoma (NB) is an aggressive childhood tumor, with high-risk cases having a 5-year overall survival probability of approximately 50%. The multimodal therapeutic approach for NB includes treatment with the retinoid isotretinoin (13-cis retinoic acid; 13cRA), which is used in the post-consolidation phase as an antiproliferation and prodifferentiation agent to minimize residual disease and prevent relapse. Through small-molecule screening, we identified isorhamnetin (ISR) as a synergistic compound with 13cRA in inhibiting up to 80% of NB cell viability. The synergistic effect was accompanied by a marked increase in the expression of the adrenergic receptor α1B (ADRA1B) gene. Genetic knockout of ADRA1B or its specific blockade using α1/α1B adrenergic antagonists led to selective sensitization of MYCN-amplified NB cells to cell viability reduction and neural differentiation induced by 13cRA, thus mimicking ISR activity. Administration of doxazosin, a safe α1-antagonist used in pediatric patients, in combination with 13cRA in NB xenografted mice exerted marked control of tumor growth, whereas each drug alone was ineffective. Overall, this study identified the α1B adrenergic receptor as a pharmacologic target in NB, supporting the evaluation of adding α1-antagonists to the post-consolidation therapy of NB to more efficiently control residual disease.

Significance:
Targeting α-adrenergic receptors synergizes with isotretinoin to suppress growth and to promote differentiation of neuroblastoma, revealing a combinatorial approach for more effective management of the disease and prevention of relapse.
The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer
Authors: Lundberg Arian , Zhang Meng , Aggarwal Rahul , Li Haolong , Zhang Li , Foye Adam , Sjöström Martin , Chou Jonathan , Chang Kevin , Moreno-Rodriguez Thaidy , Shrestha Raunak , Baskin Avi , Zhu Xiaolin , Weinstein Alana S. , Younger Noah , Alumkal Joshi J. , Beer Tomasz M. , Chi Kim N. , Evans Christopher P. , Gleave Martin , Lara Primo N. , Reiter Rob E. , Rettig Matthew B. , Witte Owen N. , Wyatt Alexander W. , Feng Felix Y. , Small Eric J. , Quigley David A. 
Published: June 2023

Abstract

Systemic targeted therapy in prostate cancer is primarily focused on ablating androgen signaling. Androgen deprivation therapy and second-generation androgen receptor (AR)–targeted therapy selectively favor the development of treatment-resistant subtypes of metastatic castration-resistant prostate cancer (mCRPC), defined by AR and neuroendocrine (NE) markers. Molecular drivers of double-negative (AR−/NE−) mCRPC are poorly defined. In this study, we comprehensively characterized treatment-emergent mCRPC by integrating matched RNA sequencing, whole-genome sequencing, and whole-genome bisulfite sequencing from 210 tumors. AR−/NE− tumors were clinically and molecularly distinct from other mCRPC subtypes, with the shortest survival, amplification of the chromatin remodeler CHD7, and PTEN loss. Methylation changes in CHD7 candidate enhancers were linked to elevated CHD7 expression in AR−/NE+ tumors. Genome-wide methylation analysis nominated Krüppel-like factor 5 (KLF5) as a driver of the AR−/NE− phenotype, and KLF5 activity was linked to RB1 loss. These observations reveal the aggressiveness of AR−/NE− mCRPC and could facilitate the identification of therapeutic targets in this highly aggressive disease.

Significance:
Comprehensive characterization of the five subtypes of metastatic castration-resistant prostate cancer identified transcription factors that drive each subtype and showed that the double-negative subtype has the worst prognosis.
Clinical and Genomic Characteristics of Patients with Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer Following Progression on Cyclin-Dependent Kinase 4 and 6 Inhibitors
Authors: Rao Xi , Chen Yongmei , Beyrer Julie , Nash Smyth Emily , Morato Guimaraes Claudia , Litchfield Lacey M. , Bowman Lee , Lawrence Garreth W. , Aggarwal Amit , Andre Fabrice 
Published: June 2023

Abstract

Purpose:
We explored the clinical and genomic characteristics of hormone receptor–positive (HR+), HER2-negative (HER2−) metastatic breast cancer (MBC) after progression on cyclin-dependent kinase 4 and 6 inhibitors (CDK4 and 6i) ± endocrine therapy (ET) to understand potential resistance mechanisms that may aid in identifying treatment options.

Experimental Design:
Patients in the United States with HR+, HER2− MBC had tumor biopsies collected from a metastatic site during routine care following progression on a CDK4 and 6i ± ET (CohortPost) or prior to initiating CDK4 and 6i treatment (CohortPre) and analyzed using a targeted mutation panel and RNA-sequencing. Clinical and genomic characteristics were described.

Results:
The mean age at MBC diagnosis was 59 years in CohortPre (n = 133) and 56 years in CohortPost (n = 223); 14% and 45% of patients had prior chemotherapy/ET, and 35% and 26% had de novo stage IV MBC, respectively. The most common biopsy site was liver (CohortPre, 23%; CohortPost, 56%). CohortPost had significantly higher tumor mutational burden (TMB; median 3.16 vs. 1.67 Mut/Mb, P &lt; 0.0001), ESR1 alteration frequency (mutations: 37% vs. 10%, FDR &lt; 0.0001; fusions: 9% vs. 2%, P = 0.0176), and higher copy-number amplification of genes on chr12q15, including MDM2, FRS2, and YEATS4 versus patients in the CohortPre group. In addition, CDK4 copy-number gain on chr12q13 was significantly higher in CohortPost versus CohortPre (27% vs. 11%, P = 0.0005).

Conclusions:
Distinct mechanisms potentially associated with resistance to CDK4 and 6i ± ET, including alterations in ESR1 and amplification of chr12q15 and CDK4 copy-number gain, were identified.
ANG2 Blockade Diminishes Proangiogenic Cerebrovascular Defects Associated With Models of Hereditary Hemorrhagic Telangiectasia
Authors: Zhou Xingyan , Pucel Jenna C. , Nomura-Kitabayashi Aya , Chandakkar Pallavi , Guidroz Adella P. , Jhangiani Nikita L. , Bao Duran , Fan Jia , Arthur Helen M. , Ullmer Christoph , Klein Christian , Marambaud Philippe , Meadows Stryder M. 
Published: June 2023

BACKGROUND:
Hereditary hemorrhagic telangiectasia (HHT) is a vascular disorder characterized by arteriovenous malformations and blood vessel enlargements. However, there are no effective drug therapies to combat arteriovenous malformation formation in patients with HHT. Here, we aimed to address whether elevated levels of ANG2 (angiopoietin-2) in the endothelium is a conserved feature in mouse models of the 3 major forms of HHT that could be neutralized to treat brain arteriovenous malformations and associated vascular defects. In addition, we sought to identify the angiogenic molecular signature linked to HHT.

METHODS:
Cerebrovascular defects, including arteriovenous malformations and increased vessel calibers, were characterized in mouse models of the 3 common forms of HHT using transcriptomic and dye injection labeling methods.

RESULTS:
Comparative RNA sequencing analyses of isolated brain endothelial cells revealed a common, but unique proangiogenic transcriptional program associated with HHT. This included a consistent upregulation in cerebrovascular expression of ANG2 and downregulation of its receptor Tyr kinase with Ig and EGF homology domains (TIE2/TEK) in HHT mice compared with controls. Furthermore, in vitro experiments revealed TEK signaling activity was hampered in an HHT setting. Pharmacological blockade of ANG2 improved brain vascular pathologies in all HHT models, albeit to varying degrees. Transcriptomic profiling further indicated that ANG2 inhibition normalized the brain vasculature by impacting a subset of genes involved in angiogenesis and cell migration processes.

CONCLUSIONS:
Elevation of ANG2 in the brain vasculature is a shared trait among the mouse models of the common forms of HHT. Inhibition of ANG2 activity can significantly limit or prevent brain arteriovenous malformation formation and blood vessel enlargement in HHT mice. Thus, ANG2-targeted therapies may represent a compelling approach to treat arteriovenous malformations and vascular pathologies related to all forms of HHT.
On Single-Objective Sub-Graph-Based Mutation for Solving the Bi-Objective Minimum Spanning Tree Problem
Authors: Bossek Jakob , Grimme Christian 
Published: June 2023

Abstract
We contribute to the efficient approximation of the Pareto-set for the classical NP-hard multiobjective minimum spanning tree problem (moMST) adopting evolutionary computation. More precisely, by building upon preliminary work, we analyze the neighborhood structure of Pareto-optimal spanning trees and design several highly biased sub-graph-based mutation operators founded on the gained insights. In a nutshell, these operators replace (un)connected sub-trees of candidate solutions with locally optimal sub-trees. The latter (biased) step is realized by applying Kruskal's single-objective MST algorithm to a weighted sum scalarization of a sub-graph.
We prove runtime complexity results for the introduced operators and investigate the desirable Pareto-beneficial property. This property states that mutants cannot be dominated by their parent. Moreover, we perform an extensive experimental benchmark study to showcase the operator's practical suitability. Our results confirm that the sub-graph-based operators beat baseline algorithms from the literature even with severely restricted computational budget in terms of function evaluations on four different classes of complete graphs with different shapes of the Pareto-front.
Traditions of the Origin and Growth of Indigenous Prophetic Church Movements in Nigeria
Authors: Nwadialor Kanayo 
Published: June 2023

Abstract
Indigenous prophetic church movements constitute a significant portion of Christianity in Africa and a unique spirit in African Christianity. Garrick Braide was the first to lead such a group in Nigeria in 1915. The Christ Apostolic Church is an ancient indigenous church in Nigeria; however, it appears that the church faces problems generated by the apparent confusion about the origin of the church. This confusion is evident in the 2018 centenary anniversary of the church, contrary to the Golden Jubilee organized in 1980. Similarly, the leaders often claim that CAC is the first indigenous Pentecostal church in Nigeria, whereas it is on record that Christ Army Church was established in 1916 by Braide and his followers. As a result, urgent need was required to interrogate the traditions of origin of these two indigenous church movements and their prophets.The findings revealed that Braide’s Christ Army Church preceded the Christ Apostolic Church of Babalola.
Three Perspectives on Marine Life in International Disputes
Authors: Helmersen Sondre Torp 
Published: June 2023

Abstract
This article charts three different approaches that international courts and tribunals have taken to marine life. Some have viewed marine life primarily as an economic resource, worthy of conservation only in order to ensure future exploitation. Others have seen marine life as an object of conservation in its own right. Yet others have tried to balance the two perspectives. The article also examines the sources that seem to have influenced the judges, finding that these range from the applicable law to external sources and contested legal principles.
Seasonal Differences of Precipitation and Microphysical Characteristics over the Asian Monsoon Region Using Spaceborne Dual-Frequency Precipitation Radar
Authors: Yamaji Moeka , Takahashi Hiroshi G. 
Published: June 2023

Abstract
This study aimed to reveal the seasonal climatic variations in the microphysical properties of precipitation over the Asian monsoon region. We used the Dual-Frequency Precipitation Radar satellite product aboard the Global Precipitation Measurement Mission Core Observatory for 8 years from 2014 to 2021 to statistically analyze the mass-weighted mean diameter (Dm) and frequency of heavy ice precipitation (graupel and hail). The results showed statistically significant seasonal changes. The microphysical characteristics of large Dm and frequent heavy ice precipitation were observed over the Indian subcontinent and Indochina Peninsula in the premonsoon season and over the western Himalayan region in the mature-monsoon season, which can be related to the intense and deeply developed precipitation systems. The relationship between precipitation rate and Dm was also examined. The results indicated that changes in Dm were not caused only by changes in precipitation rate but were probably induced by changes in precipitation characteristics. In terms of the relationship between the microphysical properties, heavy ice precipitation particles in the upper atmosphere above the melting layer were observed more frequently as Dm near the surface increased. We also studied lower-atmospheric instability by investigating the vertical gradients of the dry and moist static energies. The results indicated that instability properties were different; dry and wet instabilities were dominant in the premonsoon and monsoon seasons, respectively, consistent with the results of the precipitation characteristics.

Significance Statement
The purpose of this study was to reveal seasonal variations in precipitation microphysical characteristics, such as precipitation particle size and the existence of graupel and hail in the upper atmosphere, by climatological analysis over the Asian monsoon region. In previous studies, microphysical characteristics have mainly been addressed using ground-based observations. However, more sampling is needed to expand our understanding of climatological perspectives; therefore, we used recently available satellite observations. As a result, we found that precipitation particles at the surface were larger, and more graupel and hail existed in clouds in the premonsoon season when less precipitation was observed, compared to the mature-monsoon season when precipitation amount and frequency were abundant.
Visual Complexity of Head-Up Display in Automobiles Modulates Attentional Tunneling
Authors: Lee Jieun , Lee Nahyun , Ju Jangkyu , Chae Jihwan , Park Jiyoon , Ryu Hoe Sung , Cho Yang Seok 
Published: June 2023

Objective To investigate how the visual complexity of head-up displays (HUDs) influence the allocation of driver’s attention in two separate visual domains (near and far domains). Background The types and amount of information displayed on automobile HUDs have increased. With limited human attention capacity, increased visual complexity in the near domain may lead to interference in the effective processing of information in the far domain. Method Near-domain and far-domain vision were separately tested using a dual-task paradigm. In a simulated road environment, 62 participants were to control the speed of the vehicle (SMT; near domain) and manually respond to probes (PDT; far domain) simultaneously. Five HUD complexity levels including a HUD-absent condition were presented block-wise. Results Near domain performance was not modulated by the HUD complexity levels. However, the far domain detection accuracies were impaired as the HUD complexity level increased, with greater accuracy differences observed between central and peripheral probes. Conclusion Increased HUD visual complexity leads to a biased deployment of driver attention toward the central visual field. Therefore, the formulation of HUD designs must be preceded by an in-depth investigation of the dynamics of human cognition. Application To ensure driving safety, HUD designs should be rendered with minimal visual complexity by incorporating only essential information relevant to driving and removing driving-irrelevant or additional visual details.
Open after endovascular repair for previous extra anatomic bypass of adult coarctation
Authors: Phothikun Amarit , Yamamoto Shin , Oshima Susumu , Hirokami Tomohiro , Kishinami Goro , Ozaki Kensuke 
Published: June 2023

Background During follow-up, aneurysm formation in adults with coarctation of aorta has been reported after undergoing extra-anatomical aortic bypass grafting. Endovascular repair was a reasonable treatment option but there were still complications. Case presentation A 48-year-old male who underwent extra-anatomical aortic bypass grafting, presented with severe back pain and hemoptysis. He had a diagnosed pseudoaneurysm with concealed rupture at the bypass grafting. He underwent endovascular repair and coil embolization. A postsurgical CT-angiogram showed there was extravasation from stent into the pseudoaneurysm. An open repair with endovascular stent removal instead of restenting was performed.