bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome differences between PD-1/PD-L1 inhibitors-based monotherapy and combination treatments in NSCLC with brain metastases
Authors: Wang Haowei , Liu Fangfang , Chen Xiaoxia , Zhao Chao , Li Xuefei , Zhou Caicun , Hu Jie , Chu Qian , Jiang Tao 
Published: June 2023

Abstract
Introduction
Without the clear immunophenotyping of brain metastases (BrMs), the optimal treatment strategy based on PD-1/PD-L1 inhibitor for patients with non-small-cell lung cancer (NSCLC) and BrMs remains unknown.

Methods
308 patients with NSCLC received PD-1/PD-L1 inhibitor-based monotherapy or combination therapy were retrospectively identified. Kaplan-Meier curves with log-rank tests were used to determine the treatment outcomes differences. Transcriptomic analysis of paired primary lung lesions and BrMs were performed to dissect the specific tumor immune microenvironment (TIME) of BrMs.

Results
The presence of BrMs was associated with significantly inferior PFS (2.5 vs. 3.7 months; P = 0.0053) and OS (8.3 vs. 15.4 months; P = 0.0122) in monotherapy group, while it was only associated with poorer PFS (4.6 vs. 7.0 months; P = 0.0009) but similar OS (22.8 vs. 21.0 months; P = 0.9808) in combination treatment group. Of patients with BrMs, PD-1/PD-L1 inhibitor plus antiangiogenic therapy was associated with longest PFS (7.7 vs. 3.2 vs. 2.5 months; P = 0.0251) and OS (29.2 vs. 15.8 vs. 8.3 months; P = 0.0001) when compared with PD-1/PD-L1 inhibitor plus chemotherapy or anti-PD-1/PD-L1 monotherapy. Multivariate analyses suggested that combination treatment was independently correlated with significantly longer PFS (P = 0.028) and OS (P < 0.001) in patients with BrMs. Transcriptomic analysis showed a suppressive TIME in BrMs with decreased CD4+ T cells and M1 macrophages but increased M2 macrophages infiltration.

Conclusion
NSCLC with BrMs obtained barely satisfactory overall benefit from anti-PD-1/PD-L1 monotherapy, partly due to its immunosuppressive TIME. PD-1/PD-L1 inhibitor-based combination treatment, especially anti-PD-1/PD-L1 plus anti-angiogenic treatment, could significantly improve the clinical outcomes of patients with NSCLC and BrMs.
Investigating the material properties of hemp fiber and puffed rice for use in heritage conservation
Authors: Dar Saleh Abeer , Agiel Ahmed , Khoukhi Maatouk , Haris Sabeera 
Published: June 2023

Abstract
A nation’s customs and traditions are unique, including the appearance of its buildings. Restoring older buildings retains cultural connections and enhances sensitivity to the past. Conservation process materials must be distinguishable from originals for easy removal or change while matching features, a challenging task. The goal is to adopt materials similar in texture, scale, color, and form to the original. The increasing need for a sustainable environment attracts the scientific community towards alternative natural materials instead of traditional ones, adopting ecological principles. Eco-friendly materials from agricultural waste are less polluting. Bio-based materials, like hemp and rice, offer good thermal properties and replace traditional materials. Some are commercialized, while others are in the early production stages. Application conditions and potential adoption in heritage building conservation still need to be studied. Gaps in existing knowledge are addressed by assessing biomaterials’ physical properties in various conservation scenarios. Comparative analysis between new and conventional materials identifies vital advantages. The analysis also determines characteristics like thermal resistance, fire resistance, color, texture, environmental and health impact, and the production process. Findings indicate outstanding performance and can be developed in various colors and textures, essential for preserving the original structural appearance.
Analyzing visual behavior of consumers in a virtual reality fashion store using eye tracking
Authors: Jang Ju Yeun 
Published: June 2023

AbstractThis study investigated the visual behavior of consumers within an immersive virtual reality (VR) fashion store on the basis of their fashion involvement. Their shopping motivation was considered as a moderator. A total of 23 consumers participated, and the participants’ actual visual behaviors were recorded in real-time during their store experience section using an eye-tracking device attached to a VR head-mounted display. Results revealed that the greater the consumer’s fashion involvement, the greater their attention to the store area, and the greater their ability to observe more diverse areas in the store. Consumers with higher fashion involvement and browsing motivation spent less time focusing on the product area. Meanwhile, consumers with higher fashion involvement and searching motivation spent more time focusing on the product area. Visual attention to the store area positively affected experience satisfaction, and the effect of visual attention to the product area on satisfaction was moderated by consumers’ shopping motivation.
Development of digitized evaluation methods for fabric shrinkage and damage using image analysis
Authors: Yun Eunbi , Kim Sungmin , Yun Changsang 
Published: June 2023

AbstractThe aim of this study is to develop digitalized evaluation methods for fabric shrinkage and damage using image analysis. To develop the shrinkage assessment method, 81 grid dots (nine horizontal lines and nine vertical lines) are introduced into the test fabric. This allows the shrinkage to be verified based on the change in distance between neighboring dots, which not only presents the shrinkage in the warp and weft directions, but also the area shrinkage and skewness. The developed evaluation method yields a value that differs from the actual measured value by less than 1 mm, which confirms its significance. To develop a damage evaluation method using the Original Danish MA test fabric, the change in area caused by loosening threads in five holes is evaluated. The area change in the developed method and the number of loosened threads in the conventional method has a high correlation. Comparing the number of dots in the Poka-Dot test fabric before and after washing enables one to distinguish incorrectly created dots during the manufacturing process and to accurately measure the number of missing dots such that the result is similar to the actual measurement. The accuracy and reproducibility of the developed measurement method are confirmed using various verification such as error rate, washing cycle, and washing time. Digitizing the evaluation method can contribute to the digital transformation of apparel quality evaluation by reducing labor and errors between evaluators.
The importance of the cricoid cartilage as an anatomic land mark of cervical level
Authors: Ozalp Horsanali Burcu , Tekgul Zeki Tuncel , Esen Özgür , Şenoğlu Gizem Demir 
Published: June 2023

Abstract

Background
We aimed to evaluate the correlation of the changes radiologically in the vertebral level of the cricoid cartilage according to age and gender to reduce the application difficulties and complication rates in cervical region nerve blockades and surgeries.

Results
The mean age of all patients included in the study was 56.06 ± 17.22 years. We observed that while the line drawn from the cricoid cartilage to the vertebral column level passed over the C6 transverse process in women, it was below the C6 transverse process in men. A significant difference was also observed between the vertebral corpus level according to gender (p < 0.001). We could not find a significant difference between the transverse process and corpus level according to age.

Conclusions
We found a significant difference according to gender in the correlation of the cervical vertebra transverse process and corpus with the cricoid cartilage line which are two important levels frequently used in clinical practice to ensure successful and non-complicated blockage.
The role of miRNAs in the diagnosis and treatment of male infertility: a review study
Authors: Sinaei Roya , Jamebozorgi Khosro , Mirshekarpour Hossein , Poormasoumi Hossein , Mahdizadeh Amirhossein , Akbari Zahra , Taghizadeh Eskandar 
Published: June 2023

AbstractInfertility is a widespread issue that affects over five million couples globally. The cause of this condition can be related to women, men, or both. Male infertility, as a clinical disorder, can be caused by problems in spermatogenesis, testicular development, epididymal, and sperm maturation. Various methods have been proposed to diagnose and treat this disorder, but in some cases, it still remains idiopathic. Nowadays, the investigation of miRNAs is being discussed for the diagnosis and treatment of male infertility. miRNAs are small non-coding RNAs that regulate the expression of many genes after transcription. The aim of this review is to study miRNAs as noninvasive biomarkers for the diagnosis of infertility, as well as proposed treatment strategies and the challenges ahead in these avenues.
Risks and familial coaggregation of death by suicide, accidental death and major psychiatric disorders in first-degree relatives of individuals who died by suicide
Authors: Tsai Shih-Jen , Cheng Chih-Ming , Chang Wen-Han , Bai Ya-Mei , Hsu Ju-Wei , Huang Kai-Lin , Su Tung-Ping , Chen Tzeng-Ji , Chen Mu-Hong 
Published: June 2023

BackgroundEvidence suggests a familial coaggregation of major psychiatric disorders, including schizophrenia, bipolar disorder, major depression (MDD), autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). Those disorders are further related to suicide and accidental death. However, whether death by suicide may coaggregate with accidental death and major psychiatric disorders within families remains unclear.AimsTo clarify the familial coaggregation of deaths by suicide with accidental death and five major psychiatric disorders.MethodUsing a database linked to the entire Taiwanese population, 68 214 first-degree relatives of individuals who died by suicide between 2003 and 2017 and 272 856 age- and gender-matched controls were assessed for the risks of death by suicide, accidental death and major psychiatric disorders.ResultsA Poisson regression model showed that the first-degree relatives of individuals who died by suicide were more likely to die by suicide (relative risk RR = 4.61, 95% CI 4.02–5.29) or accident (RR = 1.62, 95% CI 1.43–1.84) or to be diagnosed with schizophrenia (RR = 1.53, 95% CI 1.40–1.66), bipolar disorder (RR = 1.99, 95% CI 1.83–2.16), MDD (RR = 1.98, 95% CI 1.89–2.08) or ADHD (RR = 1.34, 95% CI 1.24–1.44).ConclusionsOur findings identified a familial coaggregation of death by suicide with accidental death, schizophrenia, major affective disorders and ADHD. Further studies would be required to elucidate the pathological mechanisms underlying this coaggregation.
Agency and Strategy: Chastity Exemplars in an Early Qing Anthology
Authors: Moyer Jessica Dvorak 
Published: June 2023

Abstract
This article reads exemplary biographies of chaste widows and women who committed suicide to preserve their chastity in the 1656 Yuding Nei ze yanyi 御定内則衍義 (Imperially Commissioned Expanded Meaning of the “Inner Standards”) by Fu Yijian 傅以漸 (1609–1665, jinshi 1646). In this anthology commissioned by the Shunzhi emperor on behalf of his mother, Fu's commentary emphasizes both the agency of individual women and the mutual resonance of personal virtue and political order. He not only praises the exemplars' virtue but also their agency, intelligence, and strategy. He explicitly acknowledges the different factors that could make chastity more difficult and states that in some situations, multiple courses of action were possible. He comments both on his heroines' political ability and on the political importance of recognizing chastity. Finally, in a context where women's chastity was often linked to political loyalism to the fallen Ming, Fu uses these biographies in a very different way: he presents chastity exemplars of conquered dynasties as foils to the decadent society around them. His commentary is thus recognizably tailored to his audience's circumstances as Manchu and Mongolian imperial women and his own as a Chinese male scholar at the beginning of the Qing.
Direct Transorbital Approach for Treatment of Carotid Cavernous Fistula: An Illustrative Case Series
Authors: Steinberg Jeffrey A. , Brandel Michael G. , Wali Arvin R. , Mahata Sumana , Rennert Robert C. , Santiago Dieppa David R. , Pannell J. Scott , Khalessi Alexander A. , Olson Scott E. 
Published: June 2023

BACKGROUND AND OBJECTIVES:
Endovascular techniques have become the first-line treatment for carotid-cavernous fistulas (CCFs). Direct transorbital venous access may be used if anatomic constraints limit standard transarterial or transvenous access. We describe our institutional experience with the transorbital approach for Barrow Type A-D CCFs.

METHODS:
Patients with CCFs undergoing transorbital endovascular treatment at our institution between 2017 and 2019 were retrospectively reviewed. Demographic, treatment, and outcome data were collected.

RESULTS:
Eight patients met inclusion criteria, 4 female and 4 male patients. The mean age was 43 years, with 6 right-sided CCF and 2 left-sided CCFs. Symptoms were present for an average of 1.5 months before treatment. All patients presented with eye pain and subjective visual changes. Seven (87.5%) patients presented with proptosis, 6 (75%) patients had elevated intraocular pressure (IOP), and 3 (37.5%) patients had ophthalmoplegia. Six CCFs (75%) were spontaneous, and 2 CCFs (25%) were traumatic. Barrow types were A (n = 1), B (n = 1), C (n = 1), and D (n = 5). All patients underwent direct percutaneous transorbital embolization with coils followed by Onyx. Three patients had undergone prior transarterial and/or transvenous treatment. A radiographic cure was obtained in all patients after direct transorbital embolization. After CCF cure, cranial nerve palsies resolved in 66.7% of patients, visual acuity in the affected eye was improved or stable in 75% of patients, and IOP had normalized in 85.7% of patients. Proptosis improved in all patients, with complete resolution in 75%.

CONCLUSION:
Direct transorbital embolization is a safe and potentially curative treatment for all 4 Barrow types of CCFs.
How Health and Fitness Professionals Can Further Advance the Nation's Health by Working Across the Ecological Model
Authors: Brown David R. , Zaganjor Hatidza , Graff Kaitlin A. , Rose Ken , Sallis James F. 
Published: June 2023

Apply It!
From this article, readers should:
• Identify how health and fitness professionals can promote health and wellness among their fitness center, health club, or gym members, clients, patients, and communities by working collaboratively with colleagues across multiple levels of an ecological model.
• Understand how using evidence-based intervention approaches recommended by the Community Preventive Services Task Force may enhance the effect of health and fitness professionals on increasing physical activity.
• Learn why it's important to help create physical activity-friendly communities and how they can help support fitness centers, health clubs, or gyms and the efforts of members, clients, or patients to be more physically active in and out of health and fitness facilities.
• Identify ways to take action in their community in support of Active People, Healthy Nation
sm
, CDC's national initiative to increase physical activity, by creating and contributing to equitable policy, systems, and environmental changes to support active lifestyles and decrease physical inactivity.
Validated SNAP markers based on the CYP P450 87 A3 gene in coconut (Cocos nucifera) are associated with yearly stem height increase
Authors: HATTA ANDI NADIA NURUL LATHIFA , SUKMA DEWI , MASKROMO ISMAIL , SUDARSONO SUDARSONO 
Published: June 2023

Abstract. Hatta ANNL, Sukma D, Maskromo I, Sudarsono S. 2023. Validated SNAP markers based on the CYP P450 87 A3 gene in coconut (Cocos nucifera) are associated with yearly stem height increase. Biodiversitas 24: 2503-2512. Tall and dwarf coconuts are coconut types used worldwide as the parents in hybrid coconut production, and they differ in their yearly stem height. The yearly stem height of coconuts is estimated as 11 leaf scars length. The CYP P450 87 A3 gene is essential in the yearly stem-height increase (YSI) character. This study aims to validate single nucleotide-amplified polymorphism (SNAP) markers based on sequence variabilities of the coconut CYP P450 87 A3 gene and analyze their association with the coconut YSI character. The CYP P450 87 A3 partial genomic fragments were PCR amplified, sequenced, and used to develop SNAP markers. The markers were subsequently validated using 155 samples of 31 coconut varieties. The analysis showed that at least 17 single nucleotide polymorphisms (SNPs) exist in the exon-1 and 2 of the coconut CYP P450 87 A3 gene, and SNAP markers were successfully developed. Single-locus analysis showed that the validated CYP2_SNP1 SNAP marker locus was associated with coconut YSI characters. The developed SNAP marker based on the partial CYP P450 87 A3 gene can potentially support future marker-assisted selection (MAS) in coconut breeding, especially for developing coconut with low YSI character.
Ancylostomiasis in cats in Yogyakarta, Indonesia, and its causative genetic relations
Authors: DAMI JUNI CLAUDIA , DAMAYANTI LUH PUTU EKA , INDARJULIANTO SOEDARMANTO , PRIYOWIDODO DWI 
Published: June 2023

Abstract. Dami JC, Damayanti LPE, Indarjulianto S, Priyowidodo D. 2023. Ancylostomiasis in cats in Yogyakarta, Indonesia, and its causative genetic relations. Biodiversitas 24: 2605-2611. Ancylostomiasis is a zoonotic cat disease caused by one or more species of Ancylostoma spp. This study aims to determine ancylostomiasis in cats in Yogyakarta and its causative genetic relations. This research used ten cats with ancylostomiasis, based on the findings of Ancylostoma spp. eggs in their feces. Cats were examined clinically and laboratory, including blood profile and identification of Ancylostoma spp. eggs. The ITS1-5.8S-ITS2 region of Ancylostoma spp. was amplified by polymerase chain reaction (PCR) and sequenced; the results were compared with the Basic Local Alignment Search Tool (BLAST). As a result, physical examination showed that cats with ancylostomiasis suffered from diarrhea (100%), decreased appetite (70%), weakness (60%), anemia (60%), emaciation, and dull hair (10%). Blood examination showed that 5 (50%) cats had normochromic normocytic anemia, and 1 (10%) cat had hypochromic microcytic anemia. PCR tests, sequencing, and phylogenetic tests found that Ancylostoma spp. isolates had been successfully identified as Ancylostoma braziliense De Faria 1910, identical to A. braziliense from Australian isolate (DQ359149.1). Therefore, it was concluded that ancylostomiasis in cats in Yogyakarta was caused by A. braziliense.
Inheritance of seed coat color and heritability of agronomic characters of F2 population of reciprocal crosses between Fore Belu and Local Sabu mungbean varieties
Authors: MAU YOSEP SERAN , NDIWA ANTONIUS S. S. , BUNGA WIDASARI , ABIDIN ZAINAL , HARINI TITIK S. , OEMATAN SHIRLY S. , ROEFAIDA EFFY , TALOIM ARISTARKHUS , GADJI ADRIANA , RISNAWATI MARIA , NANA RIGOBERTUS ASA 
Published: June 2023

Abstract. Mau YS, Ndiwa ASS, Bunga W, Abidin Z, Harini TS, Oematan SS, Roefaida E, Taloim A, Gadji A, Risnawati M, Nana RA. 2023. Inheritance of seed coat color and heritability of agronomic characters of F2 population of reciprocal crosses between Fore Belu and Local Sabu mungbean varieties. Biodiversitas 24: 2647-2656. Mungbean (Vigna radiata (L.) R.Wilczek)
is an important pulse crop well adapted to the agro-climatic conditions of East Nusa Tenggara Province, Indonesia. However, the productivity of mungbean in East Nusa Tenggara is low (~0.5 t ha-1). Plant breeding programs can overcome this problem by assembling superior varieties. This study aimed to determine the genetic control of seed coat color and heritability of agronomic traits of F2 population of reciprocal crosses between Fore Belu and Local Sabu mungbean varieties. The observed data included seed coat color and agronomic traits. Seed coat color was subjected to chi-square analysis while agronomic traits were subjected to a simple statistical analysis. The results showed that seed coat color was controlled by one co-dominant gene. The plant heights of F2 fell between the two parental means while the number of pods and seed weight fell below the two parental means. The F2 values range was wide and the maximum F2 values were above the parental means. The phenotypic and genetic variability was wide while either the phenotypic diversity or genetic diversity was moderate to high. The heritability values of the six observed traits were high. The highest was observed on the harvesting date (0.92 and 0.94 for reciprocal crosses), whereas the lowest was on seed weight per plant (0.50 and 0.58 for reciprocal crosses).
The antioxidant potential of copper oxide nanoparticles synthesized from a new bacterial strain
Authors: ALSHAMI HASAN GHALI ABDULHASAN , AL-TAMIMI WIJDAN H. , HATEET RASHID RAHIM 
Published: June 2023

Abstract. Alshami HGA, Al-Tamimi WH, Hateet RR. 2023. The antioxidant potential of copper oxide nanoparticles synthesized from a new bacterial strain. Biodiversitas 24: 2666-2673. Copper oxide nanoparticles (CuONPs) have recently gained much attention due to their potential in various fields. The present study aimed to screen nine bacterial strains (Klebsiella quasipneumoniae KP18-31, K. pneumoniae IOB-L, K. quasipneumoniae subsp. similipneumoniae 2437, Bacillus cereus DBA1, B. thuringiensis MSP51, Neobacillus drentensis ROA042, Enterococcus faecalis 2674, Exiguobacterium mexicanum AB201, and Acinetobacter lwoffii K34) isolated from produced water of oil field reservoirs for their ability to biosynthesize CuONPs, as well as characterize and evaluate the antioxidant potential of the manufactured CuONPs. Biosynthesized CuONPs were characterized using XRD, TEM, AFM, and zeta potential analysis. In addition, the DPPH method was used to analyze the antioxidant activity of CuONPs. The results revealed that five of the nine isolates could synthesize CuONPs. B. thuringiensis MSP5 was the best and most productive among them, and it was used for the first time in this present study as an oil field bacteria for the biosynthesis of CuONPs. The results showed that CuONPs have a spherical shape with an average size of 20, 33, and 75 nm based on XRD, TEM, and AFM analysis, respectively. The zeta potential value of the synthesized CuONPs was -12.4 mV. The antioxidant results demonstrated that CuONPs have a remarkable scavenging activity with an IC50 value of 141.68 ?g/mL. This study concluded that CuONPs were excellent free radical scavengers.