bluuebunny/crossref_metadata_2025_split huggingface dataset:
Konjac Glucomannan, in Combination with Cisplatin, Suppresses Lymphoma Malignant Progression by Inducing Ferroptosis
Authors: Li Xi , Yuan Xinbei , Fu Hua , Zhou Wenyi , Xue Yingjun , Zhu Yidong , Wu Haoming , Shen Wei , Xu Min 
Published: May 2023

Introduction:
Although formerBurkitt lymphoma (BL) chemotherapies significantly enhanced clinical outcomes, chemoresistance may result in chemotherapy failures with poor prognosis. Therefore, novel strategies are urgently demanded for drug-resistant BL patients. Emerging studies showed that konjac glucomannan (KGM) plays a role in increasing tumor chemosensitivity. Nevertheless, the KGM role for BL is unclear.

Methods:
In this investigation, U937 and Raji's cells were used for cell proliferation and migration analyses using the Cell Counting Kit-8, Edu, and Transwell migration assays. Cell apoptosis was examined utilizing flow cytometry. Intracellular reactive oxygen species were detected via immunofluorescence. Ferroptosis-related gene levels were determined by RT-qPCR analysis. Xenograft tumor growth, chemotherapy resistance, and invasiveness in vivo were analyzed using nude mice.

Results:
The results showed that KGM attenuates drug resistance to cis-platinum (DDP) in Raji and U937 cells in both in vivo and in vitro experiments. DDP and KGM inhibited cell migration and pulmonary metastasis in vivo and in vitro experiments. Also, KGM treatment attenuated the drug resistance in both Raji and U937 cells by reducing GPX4 expression and inducing ferroptosis.

Conclusion:
Taken together, this study found that KGM combined with DDP suppresses lymphoma malignant progression by inducing ferroptosis.
A New Moisturiser Improves DNCB-induced Atopic Dermatitis-like
Symptoms and Restores Skin Barrier Function in BALB/c Mice
Authors: Foucher Christelle , Bisson Jean-François , Guy Martine , Nguyen Hao Trong , Hidalgo Sophie , Colin Julie , Anh Tran Tu Nguyen , Phuong Vu Thao Thi 
Published: May 2023

Introduction:
Atopic dermatitis (AD) is a chronic, inflammatory skin disorder with eczem-atous and pruritic lesions. Topical moisturisers and either topical corticosteroids or calcineurin inhibi-tors are usually recommended. Restoring the skin barrier function alleviates AD symptoms.

Objective:
To evaluate the efficacy of a new moisturiser compared to commercially available products in an AD murine model.

Methods:
Experimental AD was induced with topical applications of 2,4-DiNitroChloroBenzene (DNCB) on the shaved back skin of BALB/c mice from Day 1 to Day 38. Mice were randomized to either Vehicle/-, DNCB/-, or DNCB/Eczekalm (test product), DNCB/Atopiclair®, or DNCB/Lipikar (reference products) groups. Once daily application of either Eczekalm or Atopiclair® or Lipikar on the AD lesion was performed from Day 32 to Day 38. The AD severity index (ADSI) and animal be-haviour were monitored throughout the study. The trans-epidermal water loss (TEWL) was measured on the sacrifice day (Day 39).

Results:
At Day39, ADSI in the DNCB/Eczekalm, DNCB/Lipikar, and DNCB/Atopiclair® groups were significantly lower by -70%, -68%, and -57%, respectively, as compared to DNCB/- (p < 0.001). No sign of erythema was observed in the DNCB/Eczekalm group. Mean scores of skin oedema, excoriation, and dryness in the DNCB/Eczekalm, DNCB/Lipikar, and DNCB/Atopiclair® groups were significantly lower than in the DNCB/-. No significant difference was observed between DNCB/Eczekalm and DNCB/Lipikar groups. Mean TEWL in DNCB/Eczekalm group was significantly lower than the ones of DNCB/Atopiclair® (-43%, p < 0.001) and DNCB/Lipikar (-15%, p < 0.05).

Conclusion:
Eczekalm treatment significantly reduced the inflammatory effects due to AD and itch-ing episodes and restored the skin barrier function.
Peran Kelompok Nelayan Dalam Meningkatkan Perekonomian Masyarakat Sidoarjo
Authors: Putri Intan Purnama , Khabibah Amirotul , Febrianti Dwi Anggita , Junianda Laila Ayu , Az-Zahra Mega Aulia , Salsabila Vania Alvita 
Published: May 2023

Tujuan penelitian memiliki maksud agar mengetahui bagaimana peran kelompok nelayan dalam meningkatkan perekonomian masyarakat di Sidoarjo Desa Gisik Cemandi, Kec sedati, Kab Sidoarjo. Gisik Cemandi adalah wilayah pedesaan yang letaknya berada di daerah pesisir Sidoarjo, terletak berdekatan dengan pinggiran laut. Desa Gisik Cemandi ini dikenal masyarakat sebagai Kampung Nelayan dengan mayoritas bermata pencaharian sebagai nelayan. Metode yang digunakan menggunakan metode kualitatif dengan analisis menggunakan teori konvergensi budaya George Ritzer. Berdasarkan penelitian, kelompok nelayan tidak hanya berfungsi sebagai sarana penyaluran bantuan dari pemerintah tetapi juga berperan dalam meningkatkan kemampuan nelayan dalam mengatur dan meningkatkan kesejahteraan.Kata Kunci : Masyarakat Perikanan, Kelompok, Kesejahteraan.
Построение приближенного решения для изинговского магнетика во внешнем магнитном поле
Authors: Сёмкин С.В. , Смагин В.П. , Лаврушина Е.Г. 
Published: May 2023

Предложен способ приближенного расчета намагниченности изинговского магнетика, находящегося во внешнем магнитном поле. Этот способ основан на использовании точного или приближенного выражения для спонтанной намагниченности изинговского магнетика на этой же решетке. В способе используется отношение эффективных полей для кластеров из одного и двух узлов решетки. С помощью предложенного способа для магнетика, находящегося во внешнем поле, рассчитана зависимость намагниченности от температуры и величины внешнего поля. Предложенный способ в работе применяется к решению в приближении среднего поля, к решению в приближении Бете и к точному решению на квадратной решетке; для всех этих решений вычислены критические индексы, характеризующие поведение магнетика во внешнем поле. Ключевые слова: модель Изинга, фазовые переходы, влияние внешнего поля.
Visual Analytics of Multidimensional Oral Health Surveys: Data Mining Study
Authors: Xu Ting , Ma Yuming , Pan Tianya , Chen Yifei , Liu Yuhua , Zhu Fudong , Zhou Zhiguang , Chen Qianming 
Published: May 2023

Background
Oral health surveys largely facilitate the prevention and treatment of oral diseases as well as the awareness of population health status. As oral health is always surveyed from a variety of perspectives, it is a difficult and complicated task to gain insights from multidimensional oral health surveys.

Objective
We aimed to develop a visualization framework for the visual analytics and deep mining of multidimensional oral health surveys.

Methods
First, diseases and groups were embedded into data portraits based on their multidimensional attributes. Subsequently, group classification and correlation pattern extraction were conducted to explore the correlation features among diseases, behaviors, symptoms, and cognitions. On the basis of the feature mining of diseases, groups, behaviors, and their attributes, a knowledge graph was constructed to reveal semantic information, integrate the graph query function, and describe the features of intrigue to users.

Results
A visualization framework was implemented for the exploration of multidimensional oral health surveys. A series of user-friendly interactions were integrated to propose a visual analysis system that can help users further achieve the regulations of oral health conditions.

Conclusions
A visualization framework is provided in this paper with a set of meaningful user interactions integrated, enabling users to intuitively understand the oral health situation and conduct in-depth data exploration and analysis. Case studies based on real-world data sets demonstrate the effectiveness of our system in the exploration of oral diseases.
Older Adults’ Pain Outcomes After mHealth Interventions: Scoping Review
Authors: Shade Marcia , Kovaleva Mariya , Harp Kimberly , Martin-Hammond Aqueasha 
Published: May 2023

Background
Pain is prevalent and poorly managed in older adults. Although pain self-management strategies are helpful, adoption and access are limited; thus, technology provides an opportunity for intervention delivery. Mobile health (mHealth) is feasible to use in older adults; however, we have yet to understand the effect of mHealth pain self-management interventions on pain outcomes in older adults.

Objective
The purpose of this scoping review is to examine the characteristics of mHealth interventions and their efficacy on pain outcomes in older adults with musculoskeletal pain.

Methods
With the assistance of a medical librarian, keywords and subject headings were generated, including but not limited to mobile health application, mHealth, digital, pain, pain management, and older. A search was conducted for papers in journal databases, including PubMed, Embase, CINAHL, Scopus, and IEEE Xplore, between 2000 and 2022. Papers were screened according to predetermined inclusion and exclusion criteria, and reference lists were reviewed for additional paper inclusion. Three authors appraised the methodology of papers independently, then collaboratively to synthesize the evidence.

Results
Six publications were included in the scoping review. The design and methodology ranged widely from pilot studies to a comparative effectiveness trial. Older participants in the studies reported a variety of musculoskeletal conditions. Delivery of the mHealth pain self-management interventions incorporated mobile devices, such as a smartphone or tablet. Most mHealth-delivered interventions were multicomponent and incorporated elements of in-person and telephone access to an interventionist. The findings suggested mHealth interventions may reduce pain intensity; however, pain interference and other pain-related conditions did not have a statistically significant reduction.

Conclusions
Research that has explored mHealth for pain self-management is beginning to move beyond feasibility. The few experimental studies conducted in older adults are heterogeneous, and the interventions are mostly multicomponent. It is premature to conclude the interventions’ significant effect on pain or pain-related symptoms. As technology continues to integrate into health care, more experimental research is warranted to examine the efficacy of mHealth interventions on a variety of pain outcomes in older adults.
Comparison of Cystatin C and Creatinine in the Assessment of Measured Kidney Function during Critical Illness
Authors: Haines Ryan W. , Fowler Alex J. , Liang Kaifeng , Pearse Rupert M. , Larsson Anders O. , Puthucheary Zudin , Prowle John R. 
Published: May 2023

Background
Incomplete recovery of kidney function is an important adverse outcome in survivors of critical illness. However, unlike eGFR creatinine, eGFR cystatin C is not confounded by muscle loss and may improve identification of persistent kidney dysfunction.

Methods
To assess kidney function during prolonged critical illness, we enrolled 38 mechanically ventilated patients with an expected length of stay of >72 hours near admission to intensive care unit (ICU) in a single academic medical center. We assessed sequential kidney function using creatinine, cystatin C, and iohexol clearance measurements. The primary outcome was difference between eGFR creatinine and eGFR cystatin C at ICU discharge using Bayesian regression modeling. We simultaneously measured muscle mass by ultrasound of the rectus femoris to assess the confounding effect on serum creatinine generation.

Results
Longer length of ICU stay was associated with greater difference between eGFR creatinine and eGFR cystatin C at a predicted rate of 2 ml/min per 1.73 m2 per day (95% confidence interval [CI], 1 to 2). By ICU discharge, the posterior mean difference between creatinine and cystatin C eGFR was 33 ml/min per 1.73 m2 (95% credible interval [CrI], 24 to 42). In 27 patients with iohexol clearance measured close to ICU discharge, eGFR creatinine was on average two-fold greater than the iohexol gold standard, and posterior mean difference was 59 ml/min per 1.73 m2 (95% CrI, 49 to 69). The posterior mean for eGFR cystatin C suggested a 22 ml/min per 1.73 m2 (95% CrI, 13 to 31) overestimation of measured GFR. Each day in ICU resulted in a predicted 2% (95% CI, 1% to 3%) decrease in muscle area. Change in creatinine-to-cystatin C ratio showed good longitudinal, repeated measures correlation with muscle loss, R=0.61 (95% CI, 0.50 to 0.72).

Conclusions
eGFR creatinine systematically overestimated kidney function after prolonged critical illness. Cystatin C better estimated true kidney function because it seemed unaffected by the muscle loss from prolonged critical illness.

Clinical Trial registry name and registration number:
Skeletal Muscle Wasting and Renal Dysfunction After Critical Illness Trauma - Outcomes Study (KRATOS), NCT03736005.
PCAOB Enforcement: Toothless Body of Law or a Bite That Packs a Punch?
Authors: Mowchan Michael J. , Zhang Wei 
Published: May 2023

SUMMARY
The value of PCAOB enforcement was questioned in a 2019 Project on Government Oversight report, calling it a “toothless body of law.” However, the argument focused narrowly on the limited number of PCAOB enforcements imposed on Big 4 auditors without consideration of whether they motivate positive audit quality effects more broadly. In this paper, we summarize key findings by Lamoreaux, Mowchan, and Zhang (2023) regarding whether PCAOB enforcement provides spillover benefits, deterring audit failures. LMZ find audit quality improvements among nonsanctioned auditors following PCAOB enforcement, but the pattern of this spillover varies with auditor and enforcement characteristics. Their results suggest that even PCAOB enforcements that seem limited in scope can offer protections to investors more broadly through spillover benefits. In conclusion, we discuss potential avenues through which additional spillover benefits could occur, resulting from audit firm organizational structures, remote work environments, and emerging trends in PCAOB rule-making and enforcement.
JEL Classifications: G38; M42; M48.
The Impact of Customer-Reported Cybersecurity Breaches on Key Supplier Innovations and Relationship Disruption
Authors: He Chris Zhijian , HuangFu JiangBo , Kohlbeck Mark , Wang Lin 
Published: May 2023

ABSTRACT
Cybersecurity breaches (CBs) negatively influence the breached firms’ business functions, including their innovative investments. Recent research documents a spillover effect of CBs into supply chain firm performance. We extend this research and investigate the impact of customers’ CBs on suppliers’ innovative investments and the disruption of supplier-customer relationships. We find a significant negative association between customers’ reported CBs and suppliers’ innovative investments in the subsequent year. In addition, we find customer-reported CBs increase the likelihood of supplier-customer relationship disruption in the subsequent year. Our study contributes to the broader understanding of the negative impacts of CBs not only on the breached firm’s financial performance but also on key supplier innovation decisions.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: L14; L29; M49; O30.
Care Management Processes Important for High-Quality Diabetes Care
Authors: Peterson Kevin A. , Carlin Caroline S. , Solberg Leif I. , Normington James , Lock Eric F. 
Published: May 2023

OBJECTIVE
Identify the improvement in diabetes performance measures and population-based clinical outcomes resulting from changes in care management processes (CMP) in primary care practices over 3 years.

RESEARCH DESIGN AND METHODS
This repeated cross-sectional study tracked clinical performance measures for all diabetes patients seen in a cohort of 330 primary care practices in 2017 and 2019. Unit of analysis was patient-year with practice-level CMP exposures. Causal inference is based on dynamic changes in individual CMPs between years by practice. We used the Bayesian method to simultaneously estimate a five-outcome model: A1c, systolic and diastolic blood pressure, guideline-based statin use, and Optimal Diabetes Care (ODC). We control for unobserved time-invariant practice characteristics and secular change. We modeled correlation of errors across outcomes. Statistical significance was identified using 99% Bayesian credible intervals (analogous to P &lt; 0.01).

RESULTS
Implementation of 18 of 62 CMPs was associated with statistically significant improvements in patient outcomes. Together, these resulted in 12.1% more patients meeting ODC performance measures. Different CMPs affected different outcomes. Three CMPs accounted for 47% of the total ODC improvement, 68% of A1c decrease, 21% of SBP reduction, and 55% of statin use increase: 1) systems for identifying and reminding patients due for testing, 2) after-visit follow-up by a nonclinician, and 3) guideline-based clinician reminders for preventive services during a clinic visit.

CONCLUSIONS
Effective quality improvement in primary care focuses on practice redesign that clearly improves diabetes outcomes. Tailoring CMP adoption in primary care provides effective improvement in ODC performance through focused changes in diabetes outcomes.
Formulación del programa de telesalud en salud mental para estudiantes del sena, una apuesta a la transformación digital en salud
Authors: Gaviria Jiménez Juan José , Paez Zapata Esteban , Atehortua Castillo Diana Solange , Espriella Perdomo Mauricio de la , Salazar Marulanda Nora Luz , Vélez Rueda Lillianna 
Published: May 2023

La depresión, el estrés y la ansiedad son trastornos del ánimo frecuentes en todo tipo de población. La atención por especialistas en salud mental en nuestro medio se ve afectada por: reducido número de profesionales (psicólogos, psiquiatras) para atender a la gran cantidad de personas afectadas, mayor concentración de ayudas de salud mental en grandes centros urbanos, y carencias en la cobertura de aseguramiento en salud, entre otros. Este trabajo describe la experiencia de formulación e implementación temprana de un programa de salud mental, orientado a la detección, atención, seguimiento y educación de aprendices del SENA del Centro de Servicio de Salud, por medio de telesalud (telemedicina y tele-educación). Los aprendizajes y experiencias identificados se agruparon en 3 dominios: integrantes del equipo (personas), sistemas de información (tecnología), y procesos de atención. Se resalta la importancia de la informática clínica como eje articulador de conocimientos clínicos y tecnológicos; el trabajo integrado con prestadores de salud en temas de salud mental; y adecuación de sistemas de información al uso de escalas y gestión de datos en esquemas de seguimiento de pacientes.
La formulación e implementación de programas de atención en salud mental, integrando tecnologías, busca fortalecer las redes de atención en salud y puede mejorar la oportunidad de la atención.
The Determining Factors of Foreign Direct Investment (FDI) Inflows: Empirical Studies from the Southeast Asian Countries
Authors: Iksan Muhamad , Konishi Tetsu 
Published: May 2023

The purpose of the study estimates the possible causal relation between direct foreign investment with intertwined political and economic factors ranging from the investment climate reform initiative, tax policy conducted by the government, size of the government, and political institution. The sample of this study consists of ten countries in the Southeast Asia region. Our study utilizes time series data of 11 years from 2010 to 2020, to empirically tested three proposed hypotheses by using panel data regression analysis. Our statistical results show that determinants of direct foreign investment can be uncovered through economic rather than political factors. This study provides a negative relationship between the political institution factor (proxied by the veto player) and FDI inflow. On the contrary, the EODB score does not affect FDI inflow by controlling covariates. Moreover, our study could not provide robust evidence that an effective average tax rate could affect the FDI inflow which is contrary to literature expectation. However, our causal inference may suggest that previous FDI inflow is the best predictor for the FDI inflow.
Rough U-Exact Sequence of Rough Groups
Authors: Ayuni Fitri , Fitriani Fitriani , Faisol Ahmad 
Published: May 2023

The notion of a U-exact sequence is a generalization of the exact sequence. In this paper, we introduce a rough U-exact sequence in a rough group in an approximation space. Furthermore, we provide the properties of the rough U-exact sequence in a rough group.
Retail Vacancies in City Centres – Causes and Consequences: Findings from Turku, Finland
Authors: Marjanen Heli , Kohijoki Anna-Maija , Malmari Meri 
Published: May 2023

Abstract
This study examines ground-floor retail vacancies in Turku CBD in 2016–2021. It is based on a longitudinal database formed for the study, interviews, discussions with the stakeholders, and documentary analysis. The study found that three fourths of the vacancies were short-term. The long-term vacancies were spaces no longer meeting the requirements of contemporary retailing. In cases where property development was possible, planning disputes may prolong the vacancies for years or even decades.
Fabricate the Auto-aquaculture Structure with Android Monitoring System
Authors: Zhang Zhiyao , Tian Yueyao , Chang Shujuan , Tian Lei 
Published: May 2023

Abstract
Based on the Android monitoring system, the automated fish feeder has been developed. The system provides a convenient and reliable solution for fish farmers. This system includes a fish feeder that distributes food at predetermined intervals. The Android application allows farmers to monitor and control the feeding process remotely. The application displays the current feeding schedule. At the same time, the users can adjust the frequency and amount of food dispensed. The alarm function can send the notification information to the farmer’s mobile phone if the feeder experiences any issues or requires maintenance. By automating the feeding process and providing real-time monitoring, the system can help farmers optimize fish growth and health while reducing the time and effort required for artificial feeding.
PENGARUH SANKSI, RAZIA LAPANGAN DAN PROGRAM E-SAMSAT TERHADAP KEPATUHAN WAJIB PAJAK KENDARAAN BERMOTOR KABUPATEN SUMBAWA BARAT
Authors: Adnyani Ni Kadek Surya , Wahyu Purna Anggara I Wayan Gde 
Published: May 2023

This study aims to determine the effect of sanctions, field raids and the E-SAMSAT program on the compliance of motorized vehicle taxpayers in the district of West Sumbawa. The population in this study is motor vehicle taxpayers who use E-SAMSAT and are registered at the SAMSAT Taliwang office, West Sumbawa Regency with a sample of 100 taxpayers. The data analysis technique used in this study is multiple linear regression with data collection using a questionnaire. Based on the results of the study, it shows that tax sanctions have a positive effect on motor vehicle taxpayer compliance, field raids have a positive effect on motor vehicle taxpayer compliance, and the E-SAMSAT program has a positive effect on motor vehicle taxpayer compliance.
Keywords: Sanctions; Field Raids; e-SAMSAT; Taxpayer Compliance