bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms of Generating Emotions in Audio-Based Media
Authors: Wójciszyn-Wasil Aneta 
Published: April 2023

Audio-based content is considered to be extremely intimate and easily evoking emotions in listeners. The aim of this article is to determine the affective mechanisms used in audio productions during the COVID-19 pandemic.
The analysis focuses on radio programmes of public and commercial radio stations and the broadly defined audio media segment: podcasts and streaming services from Europe, the USA, and Australia. The content created during the so-called first wave of the pandemic (March–June 2020) was considered. Sound recordings are analysed in terms of four aspects related to the structure of audio content: words, music, acoustic effects, and silence. This study aims to present the perspective of a broadcaster who designs the audience’s affective reactions and the unique nature of radio journalists’ work during the pandemic.
The study confirmed the use of mechanisms intended to intensify and regulate emotions in audio productions in all of the analysed areas. This is especially true for emotionally-charged lexis, voice expressions, selection of musical repertoire and solutions applied in sound editing. The importance of silence as an acoustic equivalent of distance, void and isolation is emphasised. We put forward a list of mechanisms behind generating and modulating emotions in audio-based media. The study shows how sound, as diverse as it is, conveys emotions in the media.
Perspectives of Cultural Studies (Conceptualisation of Emotions in the Discourse of Cultural Studies)
Authors: Gruchoła Małgorzata 
Published: April 2023

The aim of this article is to conceptualise emotions in the discourse of cultural studies, which were initiated in the 1970s. American discourse focuses on the role of emotions in shaping individuality and subjectivity (emotional labour), while European discourse focuses on their historically and culturally conditioned constructs. Even though they have been regarded in academic discourse as opposed to reason, today it is believed that emotions determine cognitive processes, and cognitive processes can have an effect on emotions.
The article discusses theoretical concepts related to emotions: biological determinism/ biological reductionism, socio-cultural constructivism and deconstructionism, affective turn, and culture of emotions.
Perspective of the Audiovisual Arts: On Ways and Tools of Studying Emotions in the Current Visuals
Authors: Sławek-Czochra Małgorzata , Sosnowska Joanna 
Published: April 2023

Emotions in visual arts can be subject to an analysis on the level of the act of creation, the work itself, categories of technique and reception, as well as on the degree of division into form and content. Studies show a dichotomy between an intellectual (cognitive) sphere and an emotional (aesthetic) sphere, pointing to the role of recipients’ competence, allowing them to properly read the cultural and artistic code behind emotions presented in visual works.
The article is a theoretical review of methods, trends and tools for researching emotions in audiovisual arts. It presents ways of studying emotions in visual arts: film/video, photograph/graphics, all available through the media. They should be discussed on three levels: emotional objectives of the sender, emotions inherent in the artistic work, and emotional reception. Works of visual arts combine virtual and actual realities, hence the way a visual work is created is important. Therefore, the article also presents tools for the study of emotions in audiovisual art on three levels: a) in relation to means of expression, b) aesthetic, and c) presenting content. The summary clearly shows the transdisciplinary nature and methodological syncretism of research on emotions in audiovisual art.
Pregnancy programs epigenetic and transcriptional exhaustion in memory CD8+ T cells
Authors: Chong Anita , Pollard Jared , Hynes Grace , Yin Dengping , Mandal Malay , Gounari Fotini , Alegre Maria-Luisa 
Published: April 2023

Abstract
Alloreactive memory T cells, unlike naive T cells, fail to be restrained by transplantation tolerance protocols or regulatory T cells, and therefore represent a critical barrier to long-term graft acceptance. Using female mice sensitized by rejection of fully-mismatched paternal skin allografts, we show that subsequent semi-allogeneic pregnancy successfully reprograms memory fetus/graft-specific CD8+ T cells (TFGS) towards hypofunction in a manner that is mechanistically distinct from naive TFGS. Post-partum memory TFGS were durably hypofunctional, exhibiting enhanced susceptibility to transplantation tolerance induction. Furthermore, multi-omics studies revealed that pregnancy induced extensive phenotypic and transcriptional modifications in memory TFGS reminiscent of T cell exhaustion. Strikingly, at loci transcriptionally modified in both naive and memory TFGS during pregnancy, chromatin remodeling was observed exclusively in memory and not naive TFGS. These data reveal a novel link between T cell memory and hypofunction via exhaustion circuits and pregnancy-mediated epigenetic imprinting. This conceptual advance has immediate clinical relevance to pregnancy and transplantation tolerance.
Development of a novel angiotensin converting enzyme 2 stimulator with broad implications in SARS-CoV2 infection and type 1 diabetes
Authors: Nomura Haru , Wu Melanie , Song Jiangning , Hung Andrew , Tran Shirley , TA Hang , Akther Fahima , Wu Yuao , Johansen Matt , Chew Keng , Kumar Vinod , Woodruff Trent , Clark Richard , Koehbach Johannes , Lomonte Bruno , Rosado Carlos , Thomas Merlin , Boudes Marion , Reboul Cyril , Rash Lachlan , Gallo Linda , Essid Sumia , Elmlund Dominika , Miemczyk Stefan , Hansbro Nicole , Saunders Bernadette , Britton Warwick , Sly Peter , Yamamoto Ayaho , Fernández Julián , Moyle Peter , Short Kirsty , Hansbro Philip , Kuruppu Sanjaya , Smith Ian , Rajapakse Niwanthi 
Published: April 2023

Abstract
Angiotensin-converting enzyme 2 (ACE2) is protective in cardiovascular disease, lung injury and diabetes yet paradoxically underlies our susceptibility to SARs-CoV2 infection and the fatal heart and lung disease it can induce. Furthermore, diabetic patients have chronic, systemic inflammation and altered ACE2 expression resulting in increased risk of severe COVID-19 and the associated mortality. A drug that could increase ACE2 activity and inhibit cellular uptake of severe acute respiratory syndrome coronavirus 2 (SARs-CoV2), thus decrease infection, would be of high relevance to cardiovascular disease, diabetes and SARs-CoV2 infection. While the need for such a drug lead was highlighted over a decade ago receiving over 600 citations,1 to date, no such drugs are available.2 Here, we report the development of a novel ACE2 stimulator, designated ‘2A’(international PCT filed), which is a 10 amino acid peptide derived from a snake venom, and demonstrate its in vitro and in vivo efficacy against SARs-CoV2 infection and associated lung inflammation. Peptide 2A also provides remarkable protection against glycaemic dysregulation, weight loss and disease severity in a mouse model of type 1 diabetes. No untoward effects of 2A were observed in these pre-clinical models suggesting its strong clinical translation potential.
Biomechanical Study of Three Cannulated Screws Configurations for Femur Neck Fracture: A Finite Element Analysis
Authors: cui zengzhen , Fan Jixing , Cao Yuan , Fu Yuliang , Lv Yang 
Published: April 2023

Abstract
Background: To improve the performance of cannulated screws (CSs) in the treatment of femoral neck fractures (FNF), a number of new screw configurations have been proposed. However, most of the studies have only analyzed the biomechanical performance of different screw configurations under static conditions. This study aimed to investigate the biomechanical performance of three cannulated screws configurations under different loadings through finite element analysis.
Methods: A computed tomography scan of the proximal femur was performed to make a Three-dimensional (3D) model, and a fracture line was simulated in the femoral neck. The Pauwels I, II, III fracture model was fixed by three inverted triangular parallel cannulated screws (TCS), four non-parallel cannulated screws (FCS) and biplane double-supported screw fixation (BDSF) respectively. The maximum principal strain (MPS) on the proximal femur and the von Mises stress on the screws were compared for different models.
Results: In Pauwels I and II fractures, FCS had the lowest peak MPS on the proximal femur and the BDSF had highest peak MPS value. In Pauwels III fractures, BDSF performance in MPS is improved and better than FCS under partial loading conditions. FCS exhibits the lowest von Mises stress in all load conditions for all fracture types, demonstrating minimal risk of screws breakage.
Conclusions: FCS is an ideal screw configuration for the treatment of FNF. And BDSF has shown potential in the treatment of Pauwels type III FNF.
Histological and biochemical changes in a rat rotator cuff tear model with or without the subacromial bursa
Authors: Miura Yugo , Endo Kentaro , Sekiya Ichiro 
Published: April 2023

Abstract
Background
The subacromial bursa (SAB) plays an important role in the tendon healing process. Based on previous reports, co-culture of the rotator cuff (RC) and SAB have been shown to increase the expression of tendon-related genes and inflammatory cytokines, as well as to improve tensile strength in biomechanical evaluations. However, no studies have reported the nature of the biochemical changes occurring in vivo during tendon repair in the presence or absence of the SAB. In this study, we used a rat model of a full-thickness RC tear to determine how the presence or absence of the SAB alters the histological characteristics and gene expression in vivo in the injured RC.
Methods
The bilateral supraspinatus (SSP) tendons of rats were transected to create a full-thickness RC tear model. The right shoulder SAB was removed, and the left shoulder SAB was preserved. After 3 and 6 weeks, tissues were collected for histological (hematoxylin and eosin staining, Masson’s trichrome staining, immunohistochemistry) and real-time quantitative polymerase chain reaction (RT-qPCR) evaluations.
Results
Histological results revealed greater cell density (3 weeks), neovascularization within the repaired tendon (6 weeks), and tendon thickening (6 weeks) with SAB preservation. Immunostaining results revealed significant increases in type 3 collagen (COL3) expression at 6 weeks with SAB preservation. The RT-qPCR results showed that SAB preservation induced statistically significant increases in the expression of scleraxis, matrix metalloproteinase-13 (MMP-13), interleukin-1β (IL-1β), and inducible nitric oxide synthase (iNOS) at 3 weeks and significant increases in COL3, IL-10, and arginase-1 (Arg-1) at 6 weeks.
Conclusion
An RC tear undergoes more appropriate inflammatory and repair phases during the tendon repair process when the SAB is retained.
An Increasingly Growing Cyst of the Left Liver with Plenty of Small-Sized Nodules of the Cyst Lining Triggered by Chinese Clonorchiasis but Misdiagnosed as An Infectious Cystoadenocarcinoma: A Case Report
Authors: li jiacheng , Jia Zhong , Zhou He-Shan 
Published: April 2023

Abstract
Clonorchis Sinensis (CS), a trematode prevalent in East Asia, likes inhabiting the hepatobiliary tract, especially the left liver once mammal (a definitive host) such as human, cat, dog and pig accidentally eats raw or undercooked fresh water fish/shrimp contaminated by the encysted larval, this coonosis could result in bile stasis favoring bacterial growing. Liver cyst formation due to intrahepatic tract obstruction, and even cholangiocarcinoma transformation. However, liver cyst with plenty of nodules of cyst lining resulting from CS infection is seldom reported, and is easy to be misdiagnosed as cystadenoma or even cystadenocarcinoma especially in a big city without any epidemic parasite. Herein, we describe an unusual case of an infectious liver cyst with multiple nodules mimicking as cystadenocarcinoma. The patient was a 55-year-old man from China who complained of months of anorexia, malaise, and a few days of fever. Enhanced computed tomography (CT) of the abdomen revealed a huge cyst of left liver with plenty of nodules of cyst lining, containing a large amount of fine-tiny, high-dense contents and unclear cyst fluid. An infectious cystadenocarcinoma was surmized in combination with high blood neutrophilia,C-reactive protein (CRP),and high erythrocyte sedimentation rate (ESR), and high carcinoembryonic antigen (CEA) level in cyst fluid. Furthermore, no parasitic eggs in stool and left hepatobiliary tract by biopsy and drainage were observed under microscopy prior to surgery. The infectious cyst was well-controlled by 3 weeks of administration of antibiotics and continuative drainage of cyst fluid until the inflammatory markers were back to normal and the cyst volume was no longer reduced, and then left hemihepatectomy with a close cyst was performed. unexpectedly, a final conclusion of CS associated with liver cyst and granunomas of cyst lining was made on postoperative pathology. Therefore, the patient proceeded to standard flukecide therapy (3 days of praziquantel oral intake). Due to large population mobility and eating habit of local resident in developing countries, people might become an infection resource that could be walkable around. Detail-oriented radiological characteristics of CS infection associated cyst formation would be favorable for early identification, in combination with typical symptoms and high CRP and ESR especially when no evidence of CS eggs or adult worm bodies are provided.
Novel predictive scoring system for intravenous immunoglobulin resistance helps timely intervention in Kawasaki disease: the Chinese experience
Authors: Wang Yan , Guo Yanli , Wang Panpan , Wu Yan , Liu Yingying , Pan Yuting , Dong Jinyuan , Fan Zhidan , Yu Haiguo 
Published: April 2023

Abstract
Background: Approximately 10–20% of patients with Kawasaki disease (KD) are non-responsive to intravenous immunoglobulin treatment, placing them at higher risk of developing coronary heart lesions. Early detection of non-responsiveness is crucial to curtail this risk; however, the applicability of existing predictive scoring systems is limited to the Japanese population. Our study aimed to identify a predictive scoring system for intravenous immunoglobulin resistance in KD that is specific to the Chinese population. We aimed to assess the utility of three commonly used risk scoring systems in predicting intravenous immunoglobulin resistance and compare them to the newly developed predictive scoring system.
Methods: A total of 895 patients with KD were enrolled in this retrospective review and divided into two groups: intravenous immunoglobulin responders and non-responders. Clinical and laboratory variables were compared between the two groups. Multivariable logistic regression models were used to construct a new scoring system. The utility of the existing and new scoring systems was assessed and compared using the area under the receiver operating characteristic curve.
Results: Albumin levels, percentage of neutrophils, and hemoglobin were independent predictors of resistance by logistic regression analysis. The new predictive scoring system was derived with improved sensitivity (60.5%) and specificity (87.8%). The area under the receiver operating characteristic curve was 0.818.
Conclusion: This study developed a novel risk scoring system for predicting resistance to intravenous immunoglobulin treatment in KD that is specific to the Chinese population. Although this new model requires further validation, it may be useful for improving prognostic outcomes and reducing the risk of complications associated with KD.
Tool geometry and motion design in CNC machining with offset control
Authors: Zhou Shiqian , Zhou Le 
Published: April 2023

Abstract
CNC machining is the main subtractive manufacturing technique. Although it has been used for decades, it is far from perfect and still causes many problems due to complex geometric calculations. Our goal is to achieve high surface quality and to reduce the need for time-consuming finishing processes such as grinding and polishing. Our research is based on a complete geometrical analysis of the machining process and the identification of the curve by a linear-quadratic contact between the tool and the target surface. From a geometrical point of view, we succeeded in establishing a new smooth transition between the results of classical surface coverage theory and the oscillating rings on curved surfaces and the "double" oscillating rings on tangential surfaces. Unlike previous machining methods for curve matching, curve matching on curved surfaces is achieved by solving locally optimal tool position and motion planning by a single optimization.
Increased expression of CD74 in atherosclerosis associated with inflammatory responses of endothelial cells and macrophages
Authors: Ke Kun , Wu Zhengzhong , Lin Junqing , Lin Longwang , Huang Ning , Yang Weizhu 
Published: April 2023

Abstract
Background
To clarify the relationship between CD74 and atherosclerosis (AS) and the mechanisms in oxidized LDL (ox-LDL)-induced endothelial cell and macrophage injury.
Methods
Datasets obtained from the Gene Expression Omnibus database are integrated. Differentially expressed genes (DEGs) were obtained using R software. Weighted gene co-expression network analysis (WGCNA) was performed to screen the target genes. The endothelial cell injury model and macrophage foaming model were established using ox-LDL, and CD74 expression was detected by Quantitative reverse transcription PCR (RT-qPCR) and Western blot (WB). Then, after silencing CD74, cell viability and ROS production were measured, and WB detected the expression of p-p38 MAPK and NF-κB.
Results
268 DEGs were associated with AS, of which CD74 was upregulated. The turquoise module containing CD74 in WGCNA was positively associated with AS. In the endothelial cell injury model and macrophage foaming model, cell viability was significantly decreased, and CD74, ROS production, NF-κB, and p-p38MAPK expression were increased (P < 0.05). After silencing CD74, ROS production, NF-κB, and p-p38MAPK expression were decreased, and cell viability increased compared to the model group (P < 0.05).
Conclusions
CD74 is upregulated in endothelial cell injury and macrophage foaming models and is involved in AS progression via the NF-κB and MAPK signaling pathways.
Identification of secretory factors associated with suppressive tumor microenvironment in esophageal cancer
Authors: Liu Jia , Wang Dong , Zuo Xianglin , Zeng Baozhen , Yin Yin , Zhang Lu , Chai Hao , Shao Lipei 
Published: April 2023

Abstract
Esophageal squamous cell carcinoma (ESCC) is one of the deadliest solid malignancies and has a poor survival rate worldwide. Suppressive tumor microenvironment is the main cause to promote tumor development, metastasis and poor survival time. Tumor-derived secretory factors could connect tumor tissues and components in the tumor microenvironment to promote tumor progression. Here, in our study, we analyzed multiple individual transcriptome databases and found a group of secretory factors derived from tumor tissues that have correlation with infiltrated immune cells in tumor microenvironment. These secretory factors are differently expressed in esophageal tumor tissues compared with adjacent normal tissues. Among them, MFAP2 as the most significant gene was positively correlated with a serial of suppressive infiltrated immune cells, higher pathological stage and poorer overall survival time. Furthermore, we got the consistent results when we collected tissue samples from patients with ESCC and detected the expression of MFAP2 by immunohistochemistry, immunofluorescence and qRT-PCR methods. Our comprehensive analyses deciphered the prognostic, immunological, and therapeutic value of MFAP2 in esophageal cancer management, thus providing a target for individual and precise therapy for combating esophageal cancer.
BRAF Mutated LCH: Diagnosis and Treatment Challenges - A High-Risk Case Presentation and Discussion.
Authors: George Marlyn Susan , Kasem Rahim Abo , Shehnaz Fathima 
Published: April 2023

Abstract
This case report discusses the challenges in diagnosing and treating Langerhans cell histiocytosis (LCH) in a 6-month-old infant. LCH is a rare malignancy affecting only a few children each year, with a diverse range of clinical symptoms making it challenging to diagnose. The report emphasizes the importance of conducting differential diagnosis, genetic testing, and tissue sampling to accurately diagnose and treat LCH. The case study highlights the difficulties encountered during treatment and the significance of personalized treatment plans based on precise diagnosis. The patient responded well to trametinib treatment, underscoring the importance of accurate diagnosis in treating LCH.
A case of Turner syndrome of special chimeric type with papillary thyroid carcinoma and dislocation of hip joint
Authors: Huang Jinxin , Jiang Xiaohong , Wang Long 
Published: April 2023

Abstract
We found a rare clinical manifestation of Turner syndrome: thyroid papillary carcinoma,dislocation of hip joint with diabetes and osteoporosis . The patient had growth retardation, bone density:<-2.5, the chromosome karyotype 46,X,i(X)(q10)[45]/45, X[15], dislocation of both hip joints (congenital), and short femoral neck, and was diagnosed as diabetes .
Effects of different irrigation methods and mulching on yield, growth and water use efficiency of strawberry
Authors: Biswas Benukar , Timsina Jagadish , Mandal Krishna Gopal , Naorem Anandkumar 
Published: April 2023

Abstract
Optimum water supply in the root zone with precision irrigation
water management may play a key role in improving the productivity
and sustainability of strawberry (Fragaria ×
ananassa) in moist tropical sub-humid environments.
Accordingly, a greenhouse experiment was conducted from 2015-16 to
2017-18 on a Aeric Haplaquept to evaluate the effect of
irrigation (surface irrigation at furrows at irrigation water :
cumulative pan evaporation = 1, drip irrigation to meet 100, 80 and
60% of actual crop evapotranspiration demand ), and mulch (nonwoven
jute agro textile, biodegradable plastic film, rice straw, and no
mulch) regimes on strawberry. Average soil water storage in root
zone (86mm) and fraction of potential plant available water (61%)
was highest in jute agrotextile mulched and drip irrigated at 80%
actual evapotranspiration. This combination of mulch and irrigation
regime increased belowground (root length density,
7.15×103 m m-3) and above ground (leaf area
index, 9.4) crop growth and emerged as the best option with three-
and four-times higher yield (31.1 Mg
ha-1) and water use efficiency (23.1 kg
m-3), respectively than surface irrigated unmulched
strawberry. Results suggest that these findings be incorporated
into packages and practices of strawberry cultivation in the moist
tropical sub-humid region of Bengal basin and other similar
agroecological regions of South Asia.