bluuebunny/crossref_metadata_2025_split huggingface dataset:
Was verstehen Bürger*innen unter einem digitalen Setting im Kontext der Gesundheitsförderung? – Ergebnisse aus drei online-basierten World Cafés
Authors: Dongas Eleana , Stark Anna Lea , Albrecht Joanna , Wrona Kamil Joseph , Dockweiler Christoph 
Published: June 2023

Zusammenfassung
Hintergrund und Ziel
Durch die digitale Transformation haben digitale Maßnahmen zum Aufbau gesundheitsfördernder Strukturen in alltäglichen und beruflichen Settings an Bedeutung gewonnen. Zur Ableitung solcher Maßnahmen unter Berücksichtigung der Bedürfnisse von Setting-Mitgliedern soll eine Definition des Begriffs „digitales Setting“, inklusive der Aspekte des Gelingens bzw. Scheiterns der digitalen Transformation und Folgen für die Gesundheit und das Zusammenleben in Settings, aus Perspektive von Bürger*innen erarbeitet werden.

Material und Methoden
Im August 2021 wurden drei online-basierte World Cafés, angelehnt an Brown & Isaacs, mit je maximal 13 Teilnehmenden aus den Settings Bildungseinrichtung, Kommune und Verein durchgeführt (Ngesamt = 34). Sie fanden online über Zoom und Conceptboard statt. Die Auswertung der Ergebnisse erfolgte mit MAXQDA, angelehnt an die strukturierende Inhaltsanalyse nach Kuckartz.

Ergebnisse
Bürger*innen verwenden nicht den Begriff Setting, sondern Lebenswelt (LW). Unter einer digitalen LW verstehen sie ihre physisch vorhandene LW, in der in unterschiedlichem Ausmaß digitale Tools verwendet werden. Digitale LW bestehen Bürger*innen zufolge aus der digitalen Infrastruktur, Angeboten, Koordination/Planung, Informationsbereitstellung/-beschaffung und Kommunikation und sind immer als Kombination digitaler und analoger Bestandteile zu verstehen.

Diskussion und Schlussfolgerung
Die hergeleitete Definition digitaler Settings aus Perspektive von Bürger*innen zeigt Anforderungen digitaler Interventionen, die in der Setting-bezogenen Gesundheitsförderung und Prävention künftig stärker berücksichtigt werden müssen. Durch deren Berücksichtigung im Leitfaden Prävention kann zu einer zielgruppen- und bedarfsorientierten Implementierung entsprechender Maßnahmen beigetragen werden.
Hunting for superstars
Authors: Meier Martin , Sögner Leopold 
Published: June 2023

AbstractThe “superstar economy” is characterized by payoff functions that depend in a discontinuous way on the quality level of the corresponding products and services. Firm A might generate much higher returns than firm B, although A’s product is only marginally superior to B’s product. We look at an investor who considers to invest into start-ups that want to become active in one particular technological segment. Consequently only the very best few projects generate high returns. The investor is faced with a sequence of investment opportunities, observes the objective relative rankings of the corresponding projects seen so far, and must decide whether and how much to invest into the currently observed opportunity. Returns are realized at the end of the investment horizon. We derive the value functions and optimal investment rules for risk-neutral and risk averse investors. Under weak assumptions, the expected infinite horizon utility exceeds that of initial wealth. We show that for a risk-neutral investor “invest all or nothing”, depending on the project’s ranking and time of occurrence, is an optimal strategy. For a risk-averse investor the optimal rule is non-linear and path dependent. A simulation study is performed for risk-neutral and log-utility investors.
Large-scale Multi-modal Pre-trained Models: A Comprehensive Survey
Authors: Wang Xiao , Chen Guangyao , Qian Guangwu , Gao Pengcheng , Wei Xiao-Yong , Wang Yaowei , Tian Yonghong , Gao Wen 
Published: June 2023

AbstractWith the urgent demand for generalized deep models, many pre-trained big models are proposed, such as bidirectional encoder representations (BERT), vision transformer (ViT), generative pre-trained transformers (GPT), etc. Inspired by the success of these models in single domains (like computer vision and natural language processing), the multi-modal pre-trained big models have also drawn more and more attention in recent years. In this work, we give a comprehensive survey of these models and hope this paper could provide new insights and helps fresh researchers to track the most cutting-edge works. Specifically, we firstly introduce the background of multi-modal pre-training by reviewing the conventional deep learning, pre-training works in natural language process, computer vision, and speech. Then, we introduce the task definition, key challenges, and advantages of multi-modal pre-training models (MM-PTMs), and discuss the MM-PTMs with a focus on data, objectives, network architectures, and knowledge enhanced pre-training. After that, we introduce the downstream tasks used for the validation of large-scale MM-PTMs, including generative, classification, and regression tasks. We also give visualization and analysis of the model parameters and results on representative downstream tasks. Finally, we point out possible research directions for this topic that may benefit future works. In addition, we maintain a continuously updated paper list for large-scale pre-trained multi-modal big models: https://github.com/wangxiao5791509/MultiModal_BigModels_Survey.
Effect of 316L Stainless Steel Fabrication on Oxidation Resistance, Surface Morphology, and Hot Tensile Behavior
Authors: Dudziak T. , Buzolin R. , Rzad E. , Wójcicki M. , Kateusz F. , Arneitz S. , Polkowska A. 
Published: June 2023

AbstractSamples based on 316L stainless steel were prepared by conventional manufacturing process (CM) and laser powder bed fusion (L-PBF). Surface morphology changes under air oxidation in the temperature range 600-900 °C were carried out. Tensile tests were carried out in the temperature range of 700-900 °C for strain rates between 0.001 and 0.1 s−1. The materials showed good oxidation resistance up to 700 °C. The CM and L-PBF material had a high mass gain instability and similar microstructures developed under high temperatures were found in both alloys. Increased temperature increases Cr concertation in the L-PBF material up to 40 at.% at 800 °C and a rich Fe based oxide is formed at 900 °C. Slightly thicker oxide scales were formed in the CM than in the L-PBF material.The hot tensile tests reveal that a fast work hardening occurs for all hot tensile tested samples up to a strain of approximately 0.025. Low temperatures and high strain rates within the investigated range promote a second work hardening regime, while a plateau in the flow stress is observed at high temperatures and low strain rates. The highest yield stress and peak stress values are reached at 700 °C. The yield stress is nearly independent of the strain rate at 700 °C. It decreases with a decrease in strain rate for 800 and 900 °C, and it decreases with an increase in temperature. The elongation till fracture varies from 10 to 22%, and it is strongly influenced by defects inherent of the L-PBF process.
Adsorption Capabilities of Fungoid Chitosan Toward Organic Acids in Model Solutions and White Wine
Authors: Gruppi Alice , Romanini Elia , Bassani Andrea , Lambri Milena , Chinnici Fabio , Gabrielli Mario 
Published: June 2023

AbstractIn oenology, fungoid chitosan (CH) can be used as an adjuvant for microbial control, haziness prevention, metal chelation, and ochratoxin removal. In acidic media (such as wine), CH can ionise and interact with charged compounds, giving rise to a series of adsorption and/or removal phenomena, some of which potentially impairing the overall quality of wines. In this context, it is worth noting that the interaction between CH and acidic components of wines has been poorly studied so far, and detailed information on this subject is still lacking. To study those interactions, different doses of chitosan (0.5; 1.0; 2.0 g/L) were dispersed in hydro-alcoholic solution (HS), synthetic wine solution (SW), and white wine (W). Results demonstrated that the remotion of tartaric acid and the change of pH were strongly affected by the matrix and dosage. In W and SW, chitosan was found to adsorb tartaric acid up to about 200 mg/g and 350 mg/g CH, respectively. Accordingly, pH values increased; however, the magnitude depended on the matrix as a consequence of different buffer capacities. Interestingly, even in the absence of tartaric acid (e.g. in HS samples) CH addition caused a pH increase (up to 1.2 units for 2 g/L CH addition) which demonstrated that pH variations may not only depend on the amount of organic acids adsorbed. The chitosan dispersed in W showed the highest average diameter D [3,2] (127.96 μm) compared to the ones dispersed in SW (120.81 μm) and in HS (116.26 μm), probably due to the presence of organic acids on the polymer surface. The minor removal of tartaric acid in W compared to SW could probably depend on the competitive adsorption onto chitosan of other families of compounds present in wine such as polyphenols. The data suggested that chitosan addition could affect the pH and organic acid concentration of all matrices, depending on the doses and composition of the solutions.
Multiorgan immunohistochemical endothelial expression of E-selectin in a forensic case of sepsis
Authors: Bohnert Simone , Trella Stefanie , Preiß Ulrich , Bohnert Michael , Tsokos Michael , Heinsen Helmut 
Published: June 2023

AbstractSepsis is one of the major threats for the survival and prognosis of patients in intensive care units. In cases where detailed clinical data and monitoring is available, the diagnosis of sepsis is reliable. But when clinical data are incomplete or missing and sepsis is only suspected based on the autopsy results, the picture is often equivocal. This report describes the gross pathological findings obtained from the autopsy of a 48-year-old woman with Crohn’s disease after surgical intervention. Macroscopically, we found intestinal perforation and signs of peritonitis. Histologically, the pulmonary/bronchial arteries were lined with E-selectin (CD 62E)-positive endothelial cells, which are an established postmortem histological marker of sepsis. We extended our investigations to the cerebral cortex and subcortical medullary layer. The endothelium of the cortical vessels and those in the cerebral medullary layer were likewise immunopositive for E-selectin. Furthermore, numerous TMEM119-positive, highly ramified microglial cell profiles were found in the grey and white matter. Microglial cells were lining the vascular profiles. In addition, TMEM119-positive microglial profiles were abundant in the cerebrospinal fluid (CSF). Multiorgan E-selectin positivity of the vascular endothelia provides further evidence for the postmortem diagnosis of sepsis.
SEOM-GOTEL clinical guidelines on diffuse large B cell lymphoma (2022)
Authors: Gumà Josep , Palazón-Carrión Natalia , Rueda-Domínguez Antonio , Sequero Silvia , Calvo Virginia , García-Arroyo Ramón , Gómez-Codina José , Llanos Marta , Martínez-Banaclocha Natividad , Provencio Mariano 
Published: June 2023

AbstractDiffuse large B-cell lymphoma is the most frequent histological subtype of NHL and the paradigm for the management of aggressive lymphoma. An excisional or incisional lymph node biopsy evaluated by an experienced hemopathologist is recommended to establish the diagnosis. Twenty years following its introduction, R-CHOP remains the standard first-line treatment. No modification of this scheme (increased chemotherapy dose intensity, new monoclonal antibodies, or the addition of immunomodulators or anti-target agents) has significatively improved the clinical outcomes, whereas therapy for recurrence or progression is evolving rapidly. The irruption of CART cells, polatuzumab vedotin, tafasitamab, and CD20/CD3 bispecific antibodies are changing the natural history of relapsed patients and will challenge R-CHOP as the benchmark for newly diagnosed patients.
Frequency of anticancer drug use at the end of life: a scoping review
Authors: Szigethy Endre , Dorantes Rosario , Sugrañes Miguel , Madera Meisser , Sola Ivan , Urrútia Gerard , Bonfill Xavier 
Published: June 2023

Abstract
Purpose
Anticancer drug use at the end of life places potential extra burdens on patients and the healthcare system. Previous articles show variability in methods and outcomes; thus, their results are not directly comparable. This scoping review describes the methods and extent of anticancer drug use at end of life.

Methods
Systematic searches in Medline and Embase were conducted to identify articles reporting anticancer drug use at the end of life.

Results
We selected 341 eligible publications, identifying key study features including timing of research, disease status, treatment schedule, treatment type, and treatment characteristics. Among the subset of 69 articles of all cancer types published within the last 5 years, we examined the frequency of anticancer drug use across various end of life periods.

Conclusion
This comprehensive description of publications on anticancer drug use at end of life underscores the importance of methodological factors when designing studies and comparing outcomes.
I am Robot, Your Health Adviser for Older Adults: Do You Trust My Advice?
Authors: Giorgi Ioanna , Minutolo Aniello , Tirotto Francesca , Hagen Oksana , Esposito Massimo , Gianni Mario , Palomino Marco , Masala Giovanni L. 
Published: June 2023

AbstractArtificial intelligence and robotic solutions are seeing rapid development for use across multiple occupations and sectors, including health and social care. As robots grow more prominent in our work and home environments, whether people would favour them in receiving useful advice becomes a pressing question. In the context of human–robot interaction (HRI), little is known about people’s advice-taking behaviour and trust in the advice of robots. To this aim, we conducted an experimental study with older adults to measure their trust and compliance with robot-based advice in health-related situations. In our experiment, older adults were instructed by a fictional human dispenser to ask a humanoid robot for advice on certain vitamins and over-the-counter supplements supplied by the dispenser. In the first experimented condition, the robot would give only information-type advice, i.e., neutral informative advice on the supplements given by the human. In the second condition, the robot would give recommendation-type advice, i.e., advice in favour of more supplements than those suggested initially by the human. We measured the trust of the participants in the type of robot-based advice, anticipating that they would be more trusting of information-type advice. Moreover, we measured the compliance with the advice, for participants who received robot-based recommendations, and a closer proxy of the actual use of robot health advisers in home environments or facilities in the foreseeable future. Our findings indicated that older adults continued to trust the robot regardless of the type of advice received, highlighting a type of protective role of robot-based recommendations on their trust. We also found that higher trust in the robot resulted in higher compliance with its advice. The results underpinned the likeliness of older adults welcoming a robot at their homes or health facilities.
Exploring the passengers’ socio-economic structure and its impact on the perception of railway infrastructures and services in Tripura, India
Authors: Roy Stabak , Mazzulla Gabriella , Hore Samrat , Mitra Saptarshi 
Published: June 2023

AbstractThe railway is a cost-efficient transport system that ensures economic development, social well-being, environmental sustainability and regional cooperation. As a prime mode of public transportation, it provides significant passenger service throughout the world. It is necessary to understand what passengers think about railway infrastructures and services to enhance passenger satisfaction, increase ridership and reduce the railway policy gap. Many socio-economic factors like education, income and occupation may influence the epistemological thought process of passengers about railway infrastructure and service quality. This study was conducted in Tripura, North-eastern India, to examine the effect of a passenger’s socio-economic structure on their perception of railway infrastructures and services. About 735 samples were collected from all 27 railway stations of Tripura through stratified random sampling. To understand passenger perceptions about railway infrastructure, a 5-Point Likert Scale has been used. A Modified Satisfaction Index (MSI) has been proposed to analyse the degree of passenger satisfaction by modifying an existing method. The Kuppuswamy socio-economic scale has been used to identify the association of social class on passenger perception to address the policy gap and provide alternative technical solutions by formulating effective strategies for enhancing service quality. The contribution of the study is to provide insights into the importance of considering socio-economic factors in enhancing service quality and improving passenger satisfaction. Additionally, the proposed MSI can offer a reliable and practical tool for measuring passenger satisfaction with railway services.
The impact of antibiotic stewardship interventions and patient related factors on antibiotic prescribing in a vascular surgical department
Authors: Gruber M. M. , Weber A. , Jung J. , Strehlau A. , Tsilimparis N. , Draenert R. 
Published: June 2023

Abstract
Purpose
The development of guidelines tailored to the departments’ needs and counselling during ward rounds are important antibiotic stewardship (AS) strategies. The aim was to analyse the impact of AS ward rounds and institutional guidelines as well as patient-related factors on antibiotic use in vascular surgical patients.

Methods
A retrospective prescribing-analysis of 3 months (P1, P2) before and after implementing weekly AS ward rounds and antimicrobial treatment guidelines was performed. Choice of systemic antibiotics, days of antibiotic therapy and clinical data were obtained from electronic patient records.

Results
During P2, the overall antibiotic consumption as well as the use of last-resort compounds like linezolid and fluoroquinolones decreased distinctly (overall: 47.0 days of therapy (DOT)/100 patient days (PD) vs. 35.3 DOT/100PD, linezolid: 3.7 DOT/100PD vs. 1.0 DOT/100PD, fluoroquinolones: 7.0 DOT/100PD vs. 3.2 DOT/100PD) while narrow-spectrum beta-lactams increased by 48.4%. Courses of antibiotics were de-escalated more often during P2 (30.5% vs. 12.1%, p = 0.011). Only in P2, an antibiotic therapy was initiated in patients suffering from more comorbidities (i.e. higher Charlson Comorbidity Index) more frequently. Other patient factors had no distinct impact on antibiotic prescribing.

Conclusion
Weekly AS ward rounds improved adherence to institutional antibiotic treatment guidelines and antibiotic prescribing in vascular surgical patients. Clear patient-related determinants affecting choice of antibiotic therapies could not be identified.
Study on joint characteristics in laser butt welding of AMed and wrought Ti6Al4V plates
Authors: Okamoto Yasuhiro , Shinonaga Togo , Takemoto Yoshito , Okada Akira , Ochi Akihiro , Kishimoto Ryuya , Pityana Sisa , Arthur Nana , Omoniyi Peter , Mahamood Rasheedat , Maina Martin , Akinlabi Esther 
Published: June 2023

AbstractTitanium alloy Ti6Al4V has been widely applied to medical, automotive, and aerospace industries due to its excellent properties such as high strength and excellent corrosion resistance. On the other hand, additive manufacturing (AM) technology can give the freedom of design of the products. In order to spread the AMed products, the joining of AMed and wrought products are required, and it is important to understand the joint characteristics. In this study, butt welding of Ti6Al4V plate was conducted by fiber laser in argon shielding, and the joint characteristics of laser weld wrought/wrought, AMed/AMed, and AMed/wrought Ti6Al4V plates were experimentally investigated. The AMed plate has higher tensile strength than wrought plate but the elongation of AMed plate is smaller, since AMed plate has α’ martensite due to rapid cooling during laser irradiation in AM process. Then, the laser weld joint of AMed/AMed plates has higher tensile strength, but smaller elongation than that of wrought/wrought plates. The weld joint of AMed/wrought plates shows good welding state, since small heat input leads to formation of small weld bead with higher hardness between wrought and AMed plates.
Big data-based parathyroid hormone (PTH) values emphasize need for age correction
Authors: Cavalcante L. B. C. P. , Brandão C. M. Á. , Chiamolera M. I. , Biscolla R. P. M. , Junior J. V. L. , de Sá Tavares Russo P. , Morgado J. P. M. , de Francischi Ferrer C. M. A. , Vieira J. G. H. 
Published: June 2023

Abstract
Purpose
We aimed to study the relationship between aging and increased parathyroid hormone (PTH) values.

Methods
We performed a retrospective cross-sectional study with data from patients who underwent outpatient PTH measurements performed by a second-generation electrochemiluminescence immunoassay. We included patients over 18 years of age with simultaneous PTH, calcium, and creatinine measurements and 25-OHD measured within 30 days. Patients with glomerular filtration rate < 60 mL/min/1.73 m2, altered calcemia, 25-OHD level < 20 ng/mL, PTH values > 100 pg/mL or using lithium, furosemide or antiresorptive therapy were excluded. Statistical analyses were performed using the RefineR method.

Results
Our sample comprised 263,242 patients for the group with 25-OHD ≥ 20 ng/mL, that included 160,660 with 25-OHD ≥ 30 ng/mL. The difference in PTH values among age groups divided by decades was statistically significant (p < 0.0001), regardless of 25-OHD values, ≥ 20 or ≥ 30 ng/mL. In the group with 25-OHD ≥ 20 ng/mL and more than 60 years, the PTH values were 22.1–84.0 pg/mL, a different upper reference limit from the reference value recommended by the kit manufacturer.

Conclusion
We observed a correlation between aging and PTH increase, when measured by a second-generation immunoassay, regardless of vitamin D levels, if greater than 20 ng/mL, in normocalcemic individuals without renal dysfunction.
Vegan diet—alternative protein sources as potential allergy risk
Authors: Jappe Uta 
Published: June 2023

Abstract
Background
As a vegan diet is per definition a plant-based diet, consumers rely on plant protein sources in order to substitute animal proteins. Plant protein sources commonly used in this context are the following: cereals, like wheat (Triticum aestivum, Triticum durum), oat flakes; pseudo cereals like quinoa; nuts and oil seeds like cashew (Anacardium occidentale), hazelnut (Corylus avellana), walnut (Juglans regia); seeds like psyllium seeds (Plantago ovata), sesame (Sesamum indicum), and chia seed (Salvia hispanica).

Methods
In order to assess the allergy risk posed by vegan diet, a literature search focusing on the composition of this particular diet and whether the respective foods are potentially allergenic was performed.

Results
At first glance, it is evident for allergologists that these protein sources are well-known allergen sources. Particularly nuts and legumes harbour storage proteins, oleosins, and lipid transfer proteins that as such are associated with severe allergic reactions to food. In addition, there is increasing evidence that the simultaneous consumption of several of these foods may produce a summation effect where many single allergens of high allergenic potential sum up, thereby inducing anaphylaxis. Furthermore, food processing—or the lack of it—puts patients with pollen-associated food allergy at risk to react to some of the plant foods used in vegan diets.

Conclusion
Therefore, individuals with a history of atopy should be educated regarding the allergy risk of a vegan diet.