bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of three personal resources interventions on employees’ burnout
Authors: Perez-Marques Mariola , Letona-Ibañez Onintze , Amillano Alejandro , Carrasco María , Martínez-Rodríguez Silvia 
Published: July 2023

Abstract
Personal resources are related to positive psychological states that can translate into lower burnout among employees. However, although these personal resources can be promoted through ad hoc interventions, there are few studies that analyze this type of interventions in workers. The aim of this study was to assess the effectiveness of three interventions on personal resources on reducing employees' burnout. To this end, it was hypothesized that a positive psychological capital intervention (PsyCap), a job crafting intervention and a combined intervention would have a positive impact on burnout levels. This research used a quasi-experimental, longitudinal, pretest-posttest design, with repeated measures and a waiting list control group. Study participants (N = 144) were all workers divided into three interventions and a control group. This study showed that personal resources interventions were effective in reducing burnout among employees. The PsyCap intervention and the combined intervention showed the greatest efficacy. Contrary to expectations, the combined intervention did not show significantly greater efficacy than the other two experimental groups. The study concludes with a discussion of its limitations and practical implications for future personal resources intervention studies.
First Step Validation Study for Four Subtypes of Suicidality in Mental Health
Authors: Winter Remco F.P. , Meijer Connie M. , Bos Anne T. , Kool-Goudzwaard Nienke , Enterman John H. , Gemen Manuela , Nuij Chani , Hazewinkel Mirjam C. , Steentjes Danielle , Son Gabrielle E. , Beurs Derek P. , Groot Marieke H. 
Published: July 2023

Abstract
Background
Based on clinical experience, a differentiation model for suicidality consisting of four subtypes of suicidality was developed. 1) perceptual disintegration (PD), 2) primary depressive cognition (PDC), 3) psychosocial "turmoil" (PT) and 4) inadequate communication/coping (IC). A study was carried out to examine the validity of the proposed subtypes in absolute/discrete, gradual way and with a self -developed gradual questionnaire.
Objective
A first step was to examine the model and questionnaire for feasibility, reliability and validity in clinical practice. The “real life”, practical application of the model was examined, as were the resulting suggestions for improvement.
Methods
Discharge letters to general practitioners of 25 cases of anonymized suicidal emergency patients were independently reviewed and coded/classified by three psychiatrists, and three nurses. The SUICIDI-2 questionnaire was created to be able to describe our proposed subtypes of suicidal behaviour and was used in this study to allocate cases to these subtypes. Intraclass Correlation Coefficients (ICC) for absolute/discrete and gradual scores were calculated to examine the model’s validity. The study was approved by an ethical board..
Results
All reviewers were able to assign subtypes, using the SUICIDI-2’s absolute and gradual scores, for all cases. We found an average measure of good reliability for absolute/discrete subtypes. For gradual scores, we found excellent average measures for the subtype PDC, and good for the subtypes PD, PT and IC. The reliability of gradual score for the SUICIDI-2 was relatively lower than an alternative gradual scoring, but had a good ICC value for all subtypes. The formulation for PD and IC was discussed with the reviewers and agreement was found about definitions.
Conclusions
The subtypes are validly delineated. After reviewing the results though, we found the interference of substance use was not consistently assessed by all raters. This was grounds to narrow down the criteria of the questionnaire and describe the model more clearly. The SUICIDI-2 questionnaire will be revised. A follow-up study with more conclusions for validation will looked at in relation to clinical and demographic aspects. It is essential for psychologists and other professionals to be involved in the further development and follow-up of the model and validation.
A fast direct solver for surface-based whole-head modeling of transcranial magnetic stimulation
Authors: Makaroff S. N. , Qi Z. , Rachh M. , Wartman W. A. , Weise K. , Noetscher G. M. , Daneshzand M. , Deng Zhi-De , Greengard L. , Nummenmaa A. R. 
Published: July 2023

Abstract
Background: When modeling transcranial magnetic stimulation (TMS) in the brain, a fast and accurate electric field solver can support interactive neuronavigation tasks as well as comprehensive biophysical modeling.
Objective: We formulate, test, and disseminate a direct (i.e., non-iterative) TMS solver that can accurately determine global TMS fields for any coil type everywhere in a high-resolution MRI-based surface model with ~200,000 or more arbitrarily selected observation points within approximately 5 sec, with the solution time itself of 3 sec.
Method: The solver is based on the boundary element fast multipole method (BEM-FMM), which incorporates the latest mathematical advancement in the theory of fast multipole methods – an FMM-based LU decomposition. This decomposition is specific to the head model and needs to be computed only once per subject. Moreover, the solver offers unlimited spatial numerical resolution.
Results: Despite the fast execution times, the present direct solution is numerically accurate for the default model resolution. In contrast, the widely used brain modeling software SimNIBS employs a first-order finite element method that necessitates additional mesh refinement, resulting in increased computational cost. However, excellent agreement between the two methods is observed for various practical test cases following mesh refinement, including a biophysical modeling task.
Conclusion: The method can be readily applied to a wide range of TMS analyses involving multiple coil positions and orientations, including image-guided neuronavigation. It can even accommodate continuous variations in coil geometry, such as flexible H-type TMS coils. The FMM-LU direct solver is freely available to academic users.
Numerical simulations of dam-break flows of viscoplastic fluids via Shallow Water equations
Authors: Muchiri David , Hewett James N. , Sellier Mathieu , Gonzalez Miguel Moyers , Monnier Jerome 
Published: July 2023

Abstract

This paper presents simulations of channelized dam-break flows of Herschel–Bulkley viscoplastic fluids over complex topographies using the Shallow Water equations (SWEs). Particularly, the study aims at assessing the effects of rheological parameters: power-law index (n), consistency index (K) and yield stress (\tau_{c}), on the flow height and velocity over different topographies. Three practical examples of dam-break flow cases are considered: a dam-break on an inclined flat surface, a dam-break over a non-flat topography, and a dam-break over a wet bed. Effects of the bed slope and depth ratios between upstream and downstream fluid levels, on the flow behaviour are also analyzed. Numerical results are compared with experimental data from the literature, and are found to be in good agreement. Results show that for both dry and wet bed conditions, the fluid front position, the peak height, and mean velocity decrease when any of the three rheological parameters is increased. However, based on parametric sensitivity analysis, the power-law index appears to be the dominant factor in dictating the fluid behaviour. Moreover, increasing the bed slope and/or the depth ratio, the wave frontal position moves further downstream. Furthermore, the presence of an obstacle is observed to cause the formation of an upsurge that moves in the upstream direction; which increases by increasing any of the three rheological parameters. The study is useful for an in-depth understanding of the effects of rheology on catastrophic gravity driven flows of non-Newtonian fluids (like lava or mud flows) for risk assessment and mitigation.
Study corrosion inhibitor for mild steel in 1M HCl by pyrazolone-sulfonamide hybrids: Synthesis, characterization evaluation as corrosion inhibitors
Authors: Ashmawy Ashraf M. , Mostafa M. A. , Kamal Abo-Bakr , Ali Gomaa A. M. , El-Gabya M. S. A. 
Published: July 2023

Abstract
Carbon steel is widely used in the petroleum industry for pipelines, storage tanks, and equipment due to its mechanical properties, and strength. However, challenges such as environmental conditions and corrosive materials can affect its lifespan and require maintenance and repair. This work aimed to prepare pyrazalone-sulfonamide hybrids, and confirmed by mass spectra, FTIR, 1H-NMR, and 13C-NMR.These compounds were examined as mild steel corrosion inhibitors in 1 M HCl solutions at 298–323 K using the gravimetric technique, electrochemical measurement, scanning electronic microscope analysis, and quantum chemical calculations. The values of inhibitory efficiency identified by electrochemical and non-electrochemical techniques exhibit good agreement. At various temperatures and in the 50 to 500 ppm concentration range. During the adsorption process, these substances connect to the Langmuir adsorption isotherm. Some adsorption isotherm and kinetic parameters have been developed and discussed. The metal surface had a thin inhibitory protective layer, according to investigations using energy dispersive X-ray spectroscopy (EDX) and scanning electron microscope (SEM). These findings demonstrated the potential of pyrazolone-sulfonamide as effective organic corrosion inhibitors for Carbon Steel. in aggressive solution.
Unraveling the Unfolded Protein Response Signature: Implications for Tumor Immune Microenvironment Heterogeneity and Clinical Prognosis in Stomach Cancer
Authors: ouyang wenhao , Liu Yajing , Huang Hong , Tan Yujing , Huang Zhenjun , Jia Xueyuan , Yu Yunfang , Yao Herui 
Published: July 2023

Abstract

Background Stomach cancer is a leading cause of cancer-related deaths globally due to its high grade and poor response to treatment. Understanding the molecular network driving the rapid progression of stomach cancer is crucial for improving patient outcomes.Methods This study aimed to investigate the role of unfolded protein response (UPR) related genes in stomach cancer and their potential as prognostic biomarkers. RNA expression data and clinical follow-up information were obtained from the TCGA and GEO databases. An unsupervised clustering algorithm was used to identify UPR genomic subtypes in stomach cancer. Functional enrichment analysis, immune landscape analysis, and chemotherapy benefit prediction were conducted for each subtype. A prognostic model based on UPR-related genes was developed and validated using LASSO-Cox regression, and a multivariate nomogram was created. Key gene expression analyses in pan-cancer and in vitro experiments were performed to further investigate the role of the identified genes in cancer progression.Results A total of 375 stomach cancer patients were included in this study. Analysis of 113 UPR-related genes revealed their close functional correlation and significant enrichment in protein modification, transport, and RNA degradation pathways. Unsupervised clustering identified two molecular subtypes with significant differences in prognosis and gene expression profiles. Immune landscape analysis showed that UPR may influence the composition of the tumor immune microenvironment. Chemotherapy sensitivity analysis indicated that patients in the C2 molecular subtype were more responsive to chemotherapy compared to those in the C1 molecular subtype. A prognostic signature consisting of seven UPR-related genes was constructed and validated, and an independent prognostic nomogram was developed. The gene IGFBP1, which had the highest weight coefficient in the prognostic signature, was found to promote the malignant phenotype of stomach cancer cells, suggesting its potential as a therapeutic target.Conclusion This study identified distinct molecular subtypes in stomach cancer patients and developed a prognostic signature to guide personalized treatment. Targeting IGFBP1, which promotes stomach cancer malignancy, could be a promising therapeutic strategy.
Mendelian randomization investigation of the causal association between circulating cytokines and colorectal cancer
Authors: Yang Zhensong , Zhang Menglai , Zhang Yifei , Tang Yutao , Li Yanbao , Zhang Yue , Jian Mi , Jiang Lixin 
Published: July 2023

Abstract
Objective
To explore the causal relationship between colorectal cancer risk and circulating cytokines and identify potential predictive biomarkers.
Methods
This study employed a bidirectional Mendelian randomization (MR) analysis based on data from genome-wide association (GWAS) studies of colorectal cancer from people of European ancestry. The genetic variants associated with 41 circulating cytokines exposed were selected as instrumental variables for this experiment. For robustness and consistency of findings, we conducted additional sensitivity analyses and reverse Mendelian randomization assessments.
Results
The analysis revealed a strong causal relationship between colorectal cancer occurrence and Vascular Endothelial Growth Factor (VEGF), Macrophage Colony Stimulating Factor (MCSF), Interleukin-12p70 (IL-12p70), Interleukin-13(IL-13), Interleukin-10 levels (IL-10) and Interleukin-7 levels (IL-7) and demonstrated partial consistency. Sensitivity analyses indicated that IL-12p70, IL-7 and VEGF are potential colorectal cancer predictive biomarkers.
Conclusion
This Mendelian randomized study offers valuable insights into the causal relationships between specific circulating cytokines and colorectal cancer risk. The identified cytokines may serve as predictive biomarkers, enabling the development of novel diagnostic, preventive, and therapeutic approaches, but further experimental validation of their potential as diagnostic biomarkers or cancer-related pharmacological targets is necessary.
Optimal blade pitch control for enhanced vertical-axis wind turbine performance
Authors: Mulleners Karen , Fouest Sébastien Le 
Published: July 2023

Abstract
Vertical-axis wind turbines are great candidates to enable wind power extraction in urban and off-shore applications. Currently, concerns around turbine efficiency and structural integrity limit their industrial deployment. Flow control can mitigate these concerns. Here, we experimentally demonstrate the potential of individual blade pitching as a control strategy and explain the flow physics that yields the performance enhancement. We perform automated experiments using a scaled-down turbine model coupled to a genetic algorithm optimiser to identify optimal pitching kinematics at on- and off-design operating conditions. Optimal blade kinematics yields a three-fold power coefficient increase at both operating conditions compared to the non-actuated turbine and a 70% reduction in structure-threatening load fluctuations at off-design conditions.
Based on flow field measurements, we uncover how blade pitching manipulates the flow structures to enhance performance. Our results can aid vertical-axis wind turbines to increase their much-needed contribution to our energy needs.
Drug delivery of Mechlorethamine as anticancer drug by Silicon, Carbon and Aluminum Nitride nanocages
Authors: Mekkey Shereen M. , Al-dolaimy F. , Hussein Abdul-Reda Uday , Younis Shahad Mohammed Dhiaa , Kadhim Abed J. , Kareem Mustafa Wathiq Abdul , Abed Noor Kadhim , Asiri Mohammed , Alkhayyat Safa , Alsalamy Ali Hashiem 
Published: July 2023

Abstract
The adsorption of Mechlorethamine on silicon, carbon and aluminum nitride (Si76, C76 and Al38N38) nanocages are investigated. The effects of V adoption on potential of Si76, C76 and Al38N38 nanocages to delivery the Mechlorethamine are investigated. The adsorption energy, Gibbs free energy, recovery time, orbital gap energy, charge transfer of interactions of Si76, C76, Al38N38, V-Si76, V-C76 and V-Al38N38 nanocages with Mechlorethamine are calculated. Results shown that the Si76 and Al38N38 nanocage has higher potential to Mechlorethamine delivery than C76 nanocage. The V adoption of nanocages can increase the interactions of Si76, C76 and Al38N38 nanocages with Mechlorethamine and their abilities to drug delivery. Finally, results are demonstrated that the V-Si76 and V-Al38N38 are acceptable nanocages to delivery of Mechlorethamine with high performance.
A Visual Positioning Model for UAV’s Patrolling Video Sequence Images Based on DOM Rectification
Authors: Liu Haojie , Fan Wei , Wu Di 
Published: July 2023

Abstract
To solve the problem that existing methods cannot calculate positioning information of UAV’s (unmanned aerial vehicle) patrolling video sequence images accurately and robustly in real time, a visual positioning model is proposed, including a robust block-matching algorithm and a precise polynomial-rectifying algorithm. First, the robust block-matching algorithm is used to obtain the best matching area for UAV’s video sequence image on DOM(Digital Orthophoto Map), a preacquired digital orthophoto map covering the whole UAV’s patrolling region. Second, the precise polynomial-rectifying algorithm is used to calculate accurate rectification parameters of mapping UAV’s video sequence image to the best matching area obtained above, and then real time positioning of UAV’s patrolling video sequence images can be realized. Finally, the above two algorithms are analyzed and verified by three practical experiments, and results indicate that even if spatial resolution, surface specific features, illumination condition and topographic relief are significantly different between DOM and UAV’s patrolling video sequence images, proposed algorithms can still steadily realize positioning of UAV’s patrolling video sequence images with about 2.5m level accuracy in 1 second.
Effect of calcination on physicochemical and biological properties of ion-modified nanohydroxyapatite for bone tissue engineering applications
Authors: Kurzyk Agata , Szwed-Georgiou Aleksandra , Pagacz Joanna , Antosik Agnieszka , Tymowicz-Grzyb Paulina , Gerle Anna , Szterner Piotr , Włodarczyk Marcin , Płociński Przemysław , Urbaniak Mateusz M. , Rudnicka Karolina , Biernat Monika 
Published: July 2023

Abstract
The study examines the effect of calcination at a temperature of 1200°C on the physicochemical and biological properties of nanohydroxyapatite (nanoHAP) substituted with magnesium (Mg2+), strontium (Sr2+), and zinc (Zn2+). The materials were characterized by Fourier-transform spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and thermal analysis methods. Moreover, in vitro biological characterization, including cytocompatibility, cell proliferation, osteogenic potential, and reactive oxygen species production, was performed. The XRD results indicate that the ion substitution of nanoHAP has no effect on the apatite structure, and after calcination, β-tricalcium phosphate (β-TCP) is formed as an additional phase. SEM analysis showed that calcination induces the agglomeration of particles and changes in surface morphology. A decrease in the specific surface area and in the ion release rate was observed. Calcination and nanoHAP ion modification are beneficial for cell proliferation and osteoblast response and provide additional stimuli for cell commitment necessary for bone regeneration.
Comparative Analysis of Therapeutic Effect of Plasmolifting on the Ankle and Appendicular Joints
Authors: Teplov Oleg , Salikhov Ramil , Chekunov Mikhail , Galimov Damir , Pankov Igor , Teplov Alexandr 
Published: July 2023

Abstract

The case of joints of the upper and lower appendages is the matter for discussion of differences in mechanisms of therapeutic effect of the plasmolifting (PL). It involves 3–5 time injections of platelet mass extracted from autologous blood into injury area spaced a week apart. The ankle joint subjected to PL therapy, compared against knee, elbow and shoulder joints, shows an extremely low ability for restoration of its functionality. Therapeutic benefit is contributed by ability of biologically active substances (BAS) and cytokines released by platelets (Pl) for activation of metabolic processes within damaged tissues. In turn, it insures restoration of morphofunctional disorders of inflammatory genesis and reparative capabilities. Successive application of PL is directly dependent on the tissues that make up a certain joint. The positive effect of the introduction of Pl auto-suspension is determined by the presence of cytokine donor cells, especially platelet activation factor (PAF). Their sufficient amount triggers Pl granulation. An extensive capillary network results with a saturated blood supply and ensures access of granulocyte cells to the sanitized tissue. Besides, basophils and mast cells of connective tissue together with the endothelium of the above capillaries are also PAF sources. All of the above provides a positive therapeutic effect of the PL method on the knee, elbow and shoulder joints unlike the absence of its practical therapeutic effect on the ankle joint and Achilles tendon.
Concentrations and oxidative potential of fine particulate matter and black carbon inhalation doses at the major US-Mexico Port of Entry San Ysidro/El Chaparral
Authors: Zurita Rita , Quintana Penelope J.E. , Toledano-Magaña Yanis , Wakida Fernando T. , Montoya Lupita D. , Castillo J. E. 
Published: July 2023

Abstract

The San Ysidro/El Chaparral Land Port of Entry (SYPOE), located between San Diego, US and Tijuana, Mexico, is the busiest border crossing in the Western hemisphere, with long waiting times to all users. People crossing, working, or living near the SYPOE are exposed to vehicular pollutants, especially particles with aerodynamic diameters < 2.5 µm (PM2.5) and black carbon (BC), which have been linked to adverse health effects.This study presents the first PM2.5 and BC concentrations measurements made on the Mexican side of the SYPOE (2017 and 2019). The oxidative potential (OP) for PM2.5 and the inhalation dose of BC for various groups at the border were also evaluated. Autumn and winter show the highest PM2.5 concentrations at the SYPOE (mean 28.7 µg m− 3 and 28.2 µg m− 3, respectively). BC concentrations at the SYPOE were the highest in winter 2017 (mean 5.7 ± 6 µg m− 3), showing concentrations 2.3 times higher for periods with low wind speeds, compared to high winds. The highest OPDTT of PM2.5 was present in winter, with a value of 18.5 pmol min− 1 µg− 1 (0.6 nmol min− 1 m− 3). The highest average daily dose for pedestrians in autumn 2018 was 5.9 µg for a 60 min waiting time. For the workers, the highest average daily dose was in winter 2017 (19 µg for an average of a 10-hr work shift). Decreasing waiting times for pedestrians and adjusting work schedules for border workers on high concentrations days would reduce inhalation dose and improve environmental justice at the border.