bluuebunny/crossref_metadata_2025_split huggingface dataset:
How academic sabbaticals are used and how they contribute to research – a small-scale study of the University of Cambridge using interviews and analysis of administrative data
Authors: Ioppolo Becky , Wooding Steven 
Published: March 2023

Background: Academic sabbaticals are seen as an important aspect of academic life and require considerable resources, however, little research has been done into how they are used and whether their effects can be measured. We explored these issues at the University of Cambridge. Methods: A mixed method approach including 24 interviews with academics, eight interviews with administrators; alongside analysis of administrative and publication data between 2010 and 2019. Results: Academics underline the importance of sabbaticals in providing uninterrupted time for research that is used to think, explore new ideas, master new techniques, develop new collaborations, draw together previous work, set work in a wider context, and provide personal discretion in research direction. They also highlight sabbaticals’ contributions in allowing the beneficial effects of combining teaching and research, while mitigating some of the disadvantages. However, it is difficult to detect the effect of sabbaticals on publications using a time series approach. Conclusions: Sabbaticals provide manifold contributions to academic research at the University of Cambridge; however, detecting and quantifying this contribution, and extending these findings requires wider and more detailed investigation.
How food support improves mental health among people living with HIV: A qualitative study
Authors: Chayama Koharu Loulou , Hufstedler Emiliano Lemus , Whittle Henry J. , Nápoles Tessa M. , Seligman Hilary , Madsen Kimberly , Frongillo Edward A. , Weiser Sheri D. , Palar Kartika 
Published: March 2023

Background
Food insecurity is associated with poor mental health among people living with HIV (PLHIV). This qualitative study explored the mental health experiences of PLHIV participating in a medically appropriate food support program.

Methods
Semi-structured interviews were conducted post-intervention (n = 34). Interview topics included changes, or lack thereof, in mental health and reasons for changes. Interviews were audio-recorded, transcribed, and double-coded. Salient themes were identified using an inductive-deductive method.

Results
Positive changes in mental health self-reported by PLHIV included improved mood and reduced stress, worry, and anxiety. Participants attributed these changes to: 1) increased access to sufficient and nutritious foods, 2) increased social support, 3) reduced financial hardship, 4) increased sense of control and self-esteem, and 5) reduced functional barriers to eating.

Conclusions
Medically appropriate food support may improve mental health for some PLHIV. Further work is needed to understand and prevent possible adverse consequences on mental health after programs end.
El agente topo
Authors: Gutiérrez Moar M.ª Carmen , Pereira Domínguez Carmen 
Published: March 2023

Rómulo, un detective privado, recibe el encargo de una clienta interesada en averiguar si su madre —que vive en una residencia de personas mayores— está bien cuidada y con una atención médica satisfactoria, o si es víctima de maltrato, golpes o robo.
Para llevar a cabo la misión selecciona, contrata y entrena a Sergio como investigador, un hombre, enviudado recientemente, de 83 años que debe infiltrarse en el centro durante 90 días como un “agente topo”. Mientras, Sergio pone empeño en cumplir su función, para ello se entrena en el manejo del teléfono móvil y de las cámaras ocultas en las gafas y bolígrafos. Además, perfecciona su comportamiento para evitar sospechas y no descubrir su tapadera.
A medida que Sergio ejerce su rol de espía, inevitablemente, se va convirtiendo en un aliado del entrañable grupo de residentes hasta el punto de involucrarse en la vida de todas esas personas, esto es, cuarenta mujeres y cuatro hombres, dejando en todos ellos una huella imborrable.
Synthesis, characterization, anticancer, anti-inflammatory activities, and docking studies of 3,5-disubstituted thiadiazine-2-thiones
Authors: Ali Haleema , Khan Rasool , Pan Xiandao , Shaheen Farzana , Jabeen Almas , Rauf Abdur , Shah Muhammad , Rashid Umer , Al-Awthan Yahya S. , Bahattab Omar S. , Al-Duais Mohammed A. , Mubarak Mohammad S. 
Published: March 2023

Abstract
In the search for potent bioactive compounds, a series of tetrahydro-2H-1,3,5-thiadiazine-2-thiones (1–13) were synthesized in good yield and characterized by means of 1H NMR, 13C NMR, and mass spectral data. The anticancer activity of the compounds was evaluated against HeLa cell line and anti-inflammatory potential via nitric oxide (NO) inhibition. Among the screened compounds, 2-(5-(3-methoxypropyl)-6-thioxo-1,3,5-thiadiazinan-3-yl) propionic acid (3), 2-(5-cyclopropyl-6-thioxo-1,3,5-thiadiazinan-3-yl) propionic acid (5), 2-(5-cyclopropyl)-6-thioxo-1,3,5-thiadiazinan-3-yl) acetic acid (6), and 2-(5-butyl-6-thioxo-1,3,5-thiadiazinan-3-yl) acetic acid (9) were the most potent against HeLa cell line with IC50 values <4 µM, whereas the rest of the series exhibited moderate-to-good activities. All the compounds were potent NO inhibitors with IC50 values ranging from <0.4 to 14.9 µM. Docking studies, binding orientations, and interaction plots showed strong interaction of the studied compounds with the inducible NO synthase enzyme via strong hydrogen bonds and hydrophobic interactions, which authenticate the in vitro results. These newly synthesized compounds could lead to the discovery of anticancer drugs.
Scaling effect on cesium diffusion in compacted MX-80 bentonite for buffer materials in HLW repository
Authors: Liu Yi-Ling , Lin Tzu-Ting , Lee Chuan-Pin 
Published: March 2023

Abstract
In this study, radionuclide behavior in high-level radioactive waste (HLW) disposal repositories is complicated because of the spatial heterogeneity of porous media, coupled flow-transport mechanisms, and multiple chemical reaction processes. Discrepancies in the diffusion behavior of a non-sorbing tracer (HTO) and a reactive tracer (137Cs) in porous media have long been recognized but are not yet fully understood, which hinders effective assessment of the capabilities of buffer materials. This paper was dedicated to exploring and explaining the discrepancies in the transport behavior of non-sorbing and reactive tracers through laboratory experiments and an investigation of contributing mechanisms. Our results showed that for a bentonite sample of the same thickness, 137Cs has smaller apparent and less effective diffusion coefficients than those for HTO. These discrepancies can be attributed to the negative surface electric effects, atomic properties, and chemical reactions. In the case of bentonite samples with different thicknesses (0.5, 0.75, 2.0, 2.5 cm), the apparent and effective diffusion coefficients show an increasing trend with bentonite thickness. According to the experimental data and fitting results, the apparent and effective diffusion coefficients are highly related to bentonite thickness. Thus, scaling effects on transport parameters were proposed to explain the results, which were attributed to the nonuniform distribution of the pore space in the bentonite sample. The scale effect behavior of radionuclide was quantified through a regression analysis. The results can be used to improve buffer designs for radionuclides diffusion.
Some results on the value distribution of differential polynomials
Authors: Fan Jinyu , Xiao Jianbin , Fang Mingliang 
Published: March 2023

Abstract
In this article, we study some results on the value distribution of differential polynomials and mainly prove the following theorem: suppose that

P

P

is a polynomial with

deg

P
≥
3

{\rm{\deg }}\hspace{0.33em}P\ge 3

and

f

f

is a transcendental meromorphic function. Let

α

\alpha

be a small function of

f

f

. If

α

\alpha

is a constant, we also require that there exists a constant

A
≠
α

A\ne \alpha

such that

P

(

z

)

−
A

P\left(z)-A

has a zero of multiplicity at least 3. Then, for any

0
<
ε
<
1

0\lt \varepsilon \lt 1

, we have

T

(

r
,
f

)

≤
k

N

¯

r
,

1

P

(

f

)

−
α

+
S

(

r
,
f

)

,

T\left(r,f)\le k\overline{N}\left(r,\frac{1}{P(f)-\alpha }\right)+S\left(r,f),

where if

P
′

(

z

)

P^{\prime} \left(z)

has only one zero, then

k
=

1

deg

P
−
2

k=\frac{1}{{\rm{\deg }}\hspace{0.33em}P-2}

; if

P
′

(

z

)

P^{\prime} \left(z)

has two distinct zeros

a

a

and

b

b

with

P

(

a

)

≠
P

(

b

)

P\left(a)\ne P\left(b)

and

α

\alpha

is nonconstant, then

k
=

1

1
−
ε

k=\frac{1}{1-\varepsilon }

; otherwise

k
=
1

k=1

.
Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl‐CoA
Authors: Ngo Jennifer , Choi Dong Wook , Stanley Illana A , Stiles Linsey , Molina Anthony J A , Chen Pei‐Hsuan , Lako Ana , Sung Isabelle Chiao Han , Goswami Rishov , Kim Min‐young , Miller Nathanael , Baghdasarian Siyouneh , Kim‐Vasquez Doyeon , Jones Anthony E , Roach Brett , Gutierrez Vincent , Erion Karel , Divakaruni Ajit S , Liesa Marc , Danial Nika N , Shirihai Orian S 
Published: March 2023

AbstractChanges in mitochondrial morphology are associated with nutrient utilization, but the precise causalities and the underlying mechanisms remain unknown. Here, using cellular models representing a wide variety of mitochondrial shapes, we show a strong linear correlation between mitochondrial fragmentation and increased fatty acid oxidation (FAO) rates. Forced mitochondrial elongation following MFN2 over‐expression or DRP1 depletion diminishes FAO, while forced fragmentation upon knockdown or knockout of MFN2 augments FAO as evident from respirometry and metabolic tracing. Remarkably, the genetic induction of fragmentation phenocopies distinct cell type‐specific biological functions of enhanced FAO. These include stimulation of gluconeogenesis in hepatocytes, induction of insulin secretion in islet β‐cells exposed to fatty acids, and survival of FAO‐dependent lymphoma subtypes. We find that fragmentation increases long‐chain but not short‐chain FAO, identifying carnitine O‐palmitoyltransferase 1 (CPT1) as the downstream effector of mitochondrial morphology in regulation of FAO. Mechanistically, we determined that fragmentation reduces malonyl‐CoA inhibition of CPT1, while elongation increases CPT1 sensitivity to malonyl‐CoA inhibition. Overall, these findings underscore a physiologic role for fragmentation as a mechanism whereby cellular fuel preference and FAO capacity are determined.
Mutation spectrum and frequency of copy number variations of the ANOS1 gene in patients with Kallmann syndrome or normosmic isolated hypogonadotropic hypogonadism
Authors: Hye Kim Ja , Choi Yunha , Hwang Soojin , Yoon Ji-Hee , Lee Jieun , Jae Kang Min , Kim Gu-Hwan , Yoo Han-Wook , Choi Jin-Ho 
Published: March 2023

Objective
This study was performed to investigate the molecular characteristics and frequency of copy number variations (CNVs) of ANOS1 in patients with Kallmann syndrome (KS) or normosmic isolated hypogonadotropic hypogonadism (nIHH) using multiplex ligation-dependent probe amplification (MLPA) analysis and sequencing.

Methods
Among 45 patients from 43 independent families, Sanger sequencing, next-generation sequencing (NGS), or microarray was performed in 24 patients from 23 families, and MLPA was performed in 19 patients who did not show rare sequence variants (n = 18) or ANOS1 amplification by PCR (n = 1).

Results
Seven patients (four patients with KS, one patient with nIHH, one prepubertal boy with anosmia, and one newborn patient) from six families (6/43, 14%) harbored molecular defects in ANOS1 including a nonsense mutation (c.1140G>A (p.W380*)), a frameshift mutation (c.1260del (p.Q421Kfs*61)), a splice site mutation (c.1449+1G>A), an exon 7 deletion, a complete deletion, and 7.9 Mb-sized inversion encompassing ANOS1. The complete deletion of ANOS1 was identified in a neonate with a micropenis and cryptorchidism. Unilateral renal agenesis was found in three patients, whereas only one patient displayed both synkinesia and sensorineural hearing loss. There was no reversal of hypogonadotropic hypogonadism in any patient during 9.1 ± 2.9 years of treatment with testosterone enanthate.

Conclusions
Molecular defects in the ANOS1 gene could be identified in 14% of probands including various types of CNVs (3/43, 7.0%). Comprehensive analysis using sequencing and analysis for CNVs is required to detect molecular defects in ANOS1.
VALUE-FORMING CONCEPT OF EDUCATION OF PERSONALITY OF A SCHOOL STUDENT IN INDEPENDENT UKRAINE
Authors: Lemko Halyna , Didukh Iryna , Voroshchuk Oksana 
Published: March 2023

The current period of social development is characterized by important processes that take place in the student environment. Under the influence of various social and political factors, new forms of thinking appear, specific values and value orientations are formed. The formation of value orientations among schoolchildren becomes particularly acute in modern society, which today is characterized by social instability, a crisis of spirituality, morality, and neglect of legal norms. Such a situation brings to the fore the problems of forming a new person, their consciousness and self-awareness, life values, spiritual forces, opportunities and abilities. In pedagogical science, the concept is interpreted as a system of views, which is significantly different from its theory or methodology due to the fact that the concept cannot be a finally verified constructor. It needs constant refinement, its theses can be debatable and require verification by facts, require the formulation of trends and regularities. The article analyzes the leading regulatory and legal documents containing relevant provisions on the foundations of the value-forming concept of personality education: State national program "Education" ("Ukraine of the 21st century"), The Law of Ukraine "On Education", the National Strategy for the Development of Education of Ukraine for the period until 2021, Concept of national education of student youth, Program of Ukrainian patriotic education of children and student youth, The concept of the New Ukrainian School, the regional targeted social program of national-patriotic education of children and youth for 2021-2025, approved by the Ivano-Frankivsk Regional Council. We also highlighted the relevance of building and implementing the concept of raising children and youth, highlighted the purpose of the concept of raising children and youth, and characterized the main principles of building the concept.
Keywords: concept, values, education, schoolchildren, value-forming concept.
ORGANIZATIONAL AND PEDAGOGICAL CONDITIONS OF MANAGEMENT OF THE EDUCATION OF FUTURE TEACHERS IN THE CONDITIONS OF DIGITALIZATION OF EDUCATION
Authors: Prokopenko Alona 
Published: March 2023

A scientific study of the educational process of future teachers (FT) in the conditions of digitalization of education directs the author to the need to study the issue of implementing the management of the educational process. To solve this issue, it is necessary to investigate the problem of ensuring organizational and pedagogical conditions and highlight the author's vision of solving this problem. It is carried out the study and analysis of scientific research by domestic and foreign scientists regarding the understanding of the problem of pedagogical and organizational-pedagogical conditions for ensuring the educational process of FT, and the organization of these conditions during the digitalization of the educational space of higher education. The author states that the process of organizing and managing the education of future teachers should include several features. Among them, the following are highlighted: the motivational and age component, which is aimed at the activity and purposefulness of FT during education; interaction with stakeholders who put forth actual requirements for the competitiveness of graduates, as well as adjust educational programs accordingly, contribute to the deepening of the expected results of the education of FT; taking into account the peculiarities of the conditions of digitization of education, which are related to the formation of the readiness of FT to use informational and communicative means of education in their future professional activities. The article examines two organizational and pedagogical conditions for managing the education of FT in the modern conditions of digitization of higher education, namely, the modernization of the management cluster and ensuring the effectiveness of the student-centered environment. It is determined that these conditions are based on the formation of practical experience of each future specialist who is ready for the educational and scientific challenges of the present time, and is also capable of self-education in the conditions of digitalization. Thus, these organizational and pedagogical conditions contribute to the provision of productive management of the education of FT in the conditions of digitalization of education.
Keywords: conditions, digitalization, digitalization of education, future teacher (FT), education, management, management education.
STUDENT-CENTERED APPROACH IN THE SYSTEM OF QUALITY ASSURANCE OF PROFESSIONAL TRAINING OF FUTURE PROFESSIONALS
Authors: Iliichuk Liubomyra 
Published: March 2023

In the current conditions of development of higher education in Ukraine the question of realization of the idea of student-centeredness as a necessary component of the system of quality assurance of professional training of future specialists is actualized. The article considers the peculiarities of the student-centered approach as a system-forming principle of the organization of the educational environment of a higher education institution in the conditions of modern educational realities. The main ideas of student-centeredness as an approach to the organization of the educational process in accordance with its components, defined by the Law of Ukraine «On Higher Education» are analyzed and systematized. Procedures for implementing a student-centered approach in accordance with the requirements of Standards and Recommendations for Quality Assurance in the European Higher Education Area are considered. A contextual analysis of student-centeredness as a characteristic feature of higher education is carried out, on the basis of which the social (civilizational), philosophical, social, psychological, pedagogical, managerial and personal aspects of this phenomenon are distinguished. The need to create an educational environment focused on meeting the needs and interests of higher education students has been identified. The role of the idea of student-centeredness in designing the educational environment of a higher education institution is revealed. It was found that the student-centered educational environment is a set of interrelated diverse conditions for the realization of educational needs and interests of students, which includes a system of intellectual and communicative, organizational, educational, informational, technological, material and technical resources. It is emphasized that the implementation of student-centered approach outlines ways to design the educational environment of a modern university, focused on continuous development and self-improvement of future professionals, which is a necessary condition for ensuring the quality of higher education in Ukraine.
Keywords: student-centeredness, student-centered approach, educational process, educational environment, professional training, quality of higher education.
ORGANIZATION OF EDUCATIONAL COOPERATION IN A DIGITAL EDUCATIONAL ENVIRONMENT IN MATHEMATICS LESSONS IN PRIMARY SCHOOL
Authors: Kokhanovska Olena , Dovgij Oleg 
Published: March 2023

For students to successfully master mathematics in the conditions of a digital educational environment, it is important to create conditions that would promote an increase in the interest in learning of students of primary education and ensure the development of their abilities and key competencies in the learning process. The article examines the essence, content and forms of educational cooperation in remote mathematics lessons in elementary school with the help of digital applications. It is emphasized the need to use digital technologies both in the process of developing digital literacy of teachers and in the context of organizing digital cooperation between teachers and younger students in the context of using ICT tools and creating conditions for their integration into the educational process. The requirements of the Concept of the New Ukrainian School regarding the mathematical competence of lower grade students were considered. The essence of the key concepts of the research is analyzed. The principles of cooperative learning are highlighted. It was noted that the main idea of cooperative learning is to learn together, and not just to perform together. The technology of preparing and conducting a mathematics lesson using the remote form of learning in cooperation based on small groups is described. Some forms of organizing collaborative learning in remote mathematics lessons based on small groups and digital means of their implementation are outlined. Special mathematical websites and applications are presented that can significantly motivate students to solve mathematical problems, visualize content and develop key competencies of students. It was concluded that the organization of educational cooperation in a digital educational environment in mathematics lessons in elementary school involves such interaction between the teacher and students, students among themselves in the educational situation, during which the children's established methods of action are restructured, the components of educational activity are formed (that is, formed learning ability).
Keywords: cooperation, educational cooperation, digital educational environment, digital applications, students of lower grades, mathematics.