bluuebunny/crossref_metadata_2025_split huggingface dataset:
RECONSTRUCTION OF TOPOLOGY OPTIMIZED GEOMETRY WITH CASTING CONSTRAINTS IN A FEATURE-BASED APPROACH
Authors: Mayer Johannes , Denk Martin , Wartzack Sandro 
Published: June 2023

AbstractTopology Optimization (TO) is an established method for the development of high strength and lightweight structural components. However, its results have to be geometrically revised to obtain a computational model that meets product development requirements. Design has to be in accordance with manufacturing constraints. Geometry reconstruction therefore still is a typically manual and tedious task, but increasingly supported by computational and automated approaches. In this paper, the inclusion of a casting constraint in an automated Medial Axis based reconstruction method is presented. Since the Medial Axis provides cross-section values by the computation of maximally inscribed spheres, this information is used for geometry reconstruction and even further for the purposeful adaption of the cross-section to match Heuver's circle method. Thereby, the directed solidification of molten material is considered. With a predefined feeder position, the demonstrator of a suspension control arm is used to show the application of the method. Resulting CAD-models are also structurally evaluated for their stiffness characteristics.
SYSTEMATIC CLASSIFICATION OF ADAPTIVE FAÇADES – PREPARING A DATABASE
Authors: Voigt Michael P. , Roth Daniel , Kreimeyer Matthias 
Published: June 2023

AbstractAdaptive façades (AF) present a promising approach to reduce environmental impacts in the Architecture, Engineering, and Construction sector. However, the automatization of the façade produces new challenges as the complexity of the system increases. To support the early phase of interdisciplinary development, solution collections such as databases are helpful. Previous research identified that existing solution collections of AF do not meet the requirements that such a method demands. In the effort to develop an optimized database, this paper investigates how the state of the art can be structured in terms of content in order to present it in the database. Here, a set of design parameters is developed based on identified requirements and on the main characteristics of AF that were previously elaborated. This set offers a comprehensive perspective on the previously realized functions and mechanisms of AF and can also contribute to finding creative solutions in the form of new concepts by combining the design parameters in new ways. Finally, 40 case studies of previously implemented adaptive façades are used to evaluate the set of design parameters.
TOWARDS THE DESIGN OF SUSTAINABLE MOBILITY SYSTEMS: OBJECTIVES AND BARRIERS FROM THE FRENCH LOCAL AUTHORITIES’ PERSPECTIVE
Authors: Baltazar Julien , Bouillass Ghada , Vallet Flore , Puchinger Jakob , Perry Nicolas 
Published: June 2023

AbstractWithin the on-going ecological transition, mobility systems are considered as sociotechnical systems that raise several challenges for local authorities due to the different levels of decision, a complex stakeholder network and the numerous objectives to be dealt with. Designers are therefore seeking to develop new frameworks to support local authorities moving towards more sustainable mobility systems. Based on the French context, this study relies on an analysis of the regulation and an interview-based survey that depict the mobility design from the local authorities’ perspective. First, it investigates the objectives defined in the law and the difficulties met by local authorities. Then, it highlights the main political, organisational, and knowledge barriers for sustainable mobility. Finally, it proposes a set of recommendations to create a framework to better define and prioritise the objectives, ensure efficient planning and monitoring, clarify the interactions between actors, and enhance mobility plans.
CHALLENGES IN EXTRACTING INSIGHTS FROM LIFE CYCLE ASSESSMENT DOCUMENTS DURING EARLY STAGE DESIGN
Authors: Goridkov Nicole , Ye Kelly , Wang Ye , Goucher-Lambert Kosa 
Published: June 2023

AbstractLife cycle assessment (LCA) has been established as a benchmark for design for sustainability practices. LCA provides detailed technical documents regarding a product's environmental impact, but its use is often limited to trained experts who share the knowledge with designers. Life cycle experts are highly specialized, and the typical designer faces technical barriers and time constraints in extracting information from LCA documents. This work uses knowledge transfer principles to replicate expert practices in LCA information retrieval to support designers. Life-cycle experts (n = 4) were interviewed to understand practices and challenges in information retrieval for LCA documents. Interview findings were used to create a set of guidelines for effectively navigating LCA documents and then tested in a follow-up task where designers (n = 16) annotated an electric toothbrush LCA using the identified guidelines. Results find designers can effectively extract information from LCA documents given provided guidelines, but need detailed support interpreting complex visual entities like charts and figures. This work is the first step toward enabling knowledge transfer from LCA documents and building a structured sustainability knowledge base.
CO-CREATE FINANCIAL PLANNING SERVICES FOR AN AGING POPULATION: DESIGNERS' PERSPECTIVES
Authors: Lee Sheng-Hung , Coughlin Joseph F. , Yang Maria , de Weck Olivier L. , Lee Chaiwoo , Klopfer Eric , Ochsendorf John 
Published: June 2023

AbstractThe purpose of the study is to understand the design considerations for creating a provocative financial planning toolkit with services to help facilitate more constructive and meaningful conversations to build trust and empathy between financial advisors and senior people. We conducted four rounds of 60-minute co-creation workshops with eight invited participants from various design disciplines to work in pairs to generate four preliminary concepts suggesting design considerations. We used ATLAS.ti to do qualitative research analysis under an NCT (notice, collecting, thinking) model to identify 22 codes synthesized from verbal and behavioral data. The study concluded with three design principles: 1) the concept of financial planning is about people's expectation management, 2) a financial planning toolkit is designed under service systems, and 3) the tailor-made and modular design features can give financial advisors more flexibility to engage with senior people and enable them to share more about their life stories and needs to recommend financial planning packages precisely according to personal preference, health conditions, and financial status.
DIDYMUS’ COMMENTARY ON PINDAR'S PAEANS
Authors: Prodi Enrico Emanuele 
Published: June 2023

AbstractThis article examines the citation of Didymus’ ‘first’ commentary on Pindar's Paeans in Ammon. Diff. 231 Nickau. It argues that the commentary on the Paeans was the first volume in Didymus’ commentary to all of Pindar.
Logistics of care: Trust-reform and self-managing teams in municipal home care services
Authors: Hansen Helle Cathrine , Neumann Cecilie Basberg 
Published: June 2023

Abstract
The central idea in trust-reform is to improve service delivery by granting professional autonomy and acknowledging the experiential knowledge of professionals. In this article, we study trust-reform bottom-up from the perspective of frontline care workers. Our aim is to discuss the challenges for care work and care workers who have been organised in self-managing teams, paying particular attention to the organising of the daily work in the teams. This study draws on data from four months of fieldwork in Norwegian municipal home care services for older people. The article sheds light on some problematic aspects in trust-reform regarding the relationship between frontline workers’ autonomy and responsibility on the one hand and the lack of authority and managerial support on the other hand. The study demonstrates that trust-reforms within public service delivery can be experienced as delegation of logistical tasks and enhanced responsibility instead of delegation of the authority that is necessary for professional care work to be performed. As such, trust-reforms risk obstructing rather than advancing their declared intentions of strengthening professional agency in care work, and rather than distributing management tasks, trust-reforms need to strengthen the management function in order to succeed.
Kaposiform hemangioendothelioma of the heart: a case report and literature review
Authors: Fan Di , Cui Yun , Chen Jing , He Xinjian 
Published: June 2023

AbstractKaposiform hemangioendothelioma is a rare tumour of vascular origin that rarely occurs in the heart. We provided a rare case of a 26-day-old infant with tachypnoea. Echocardiography showed a solid tumour in the pericardial cavity and a large amount of pericardial effusion. The solid tumour was confirmed by surgery, and the pathology was kaposiform hemangioendothelioma. We analysed this case and reviewed the related literature to explore the clinical features and echocardiographic manifestations to improve the understanding, diagnosis, and treatment of this disease for clinicians and sonographers.
The Effect of Counterstereotypic Gender Strategies on Candidate Evaluations in American Elections
Authors: Wang Ding , Merolla Jennifer L. , Manganiello Arielle 
Published: June 2023

AbstractWomen who ran for office in 2018 used a variety of strategies on the campaign trail, with some highlighting more masculine traits and others more feminine traits, but the latter was more common than in prior years. We ask how effective these strategies are for trait evaluations, perceptions of leadership and competence, likeability, and vote choice and how this effect varies based on respondent’s views about the role of women in society. To explore these relationships, we use data from a two-wave panel conducted in the winter of 2019. Results from our experiment show that female candidates who highlight more masculine traits are perceived as more agentic, less communal, and more competent, and, importantly, they do not appear to suffer from a backlash effect. Those higher in sexism also evaluate women who display these qualities as more competent, though as less warm and likable.
Comparing the Effect of Anthropogenically Amplified Halogen Natural Emissions on Tropospheric Ozone Chemistry Between Pre‐Industrial and Present‐Day
Authors: Barrera Javier A. , Kinnison Douglas E. , Fernandez Rafael P. , Lamarque Jean‐François , Cuevas Carlos A. , Tilmes Simone , Saiz‐Lopez Alfonso 
Published: June 2023

AbstractReactive halogens (X + XO, X = I, Br or Cl) catalytically destroy a fraction of tropospheric ozone under present‐day (PD) conditions, however, their distribution and potential impact on tropospheric ozone under pre‐industrial (PI) conditions remain largely unexplored. This study uses the Community Atmosphere Model with Chemistry (CAM‐Chem) to investigate the effect of anthropogenically amplified natural emissions of halogenated species and their subsequent chemistry on tropospheric ozone under PI and PD atmospheric conditions. Model results show that the global tropospheric ozone depletion due to natural halogens is slightly more sensitive in PI than PD, with percentage changes in tropospheric ozone burden (TOB) of −14.1 ± 0.6% for PI and −12.9 ± 0.6% for PD. Individually, the role of iodine and chlorine in ozone depletion is equivalent in both periods (ΔTOBI: ∼−7% and ΔTOBCl: ∼−2.5%), while bromine plays a larger role in PI (ΔTOBBr: −5.5 ± 0.6%) versus PD (ΔTOBBr: −4.3 ± 0.7%). The increase in anthropogenic ozone precursor emissions from PI to PD has amplified the natural emission of inorganic halogens and led to a shift in the partitioning of inorganic halogens from reactive to reservoir species. Consequently, halogen‐driven ozone depletion from the surface to the free troposphere is larger in PI than PD. In contrast, in the upper troposphere, the ozone depletion is larger in PD influenced mainly by stratospheric intrusion of reactive halogens from long‐lived species. This study highlights the importance of including a complete chemical coupling of natural halogens and atmospheric pollutants in chemistry‐climate models to adequately assess their effects on tropospheric ozone in a changing climate.
Estimating Paleointensities From Chemical Remanent Magnetizations of Magnetite Using Non‐Heating Methods
Authors: Maurel C. , Gattacceca J. 
Published: June 2023

AbstractMany meteorites experienced aqueous alteration on their parent body. During this process, magnetite usually forms and acquires a chemical remanent magnetization (CRM) if growing in the presence of a magnetic field. The epoch of aqueous alteration on planetesimals encompasses the lifetime of the solar nebula. Therefore, magnetite‐bearing meteorites are potential sources of invaluable data regarding the intensity of the solar nebula magnetic field and its influence on planetary accretion. The major limitation encountered in meteorite paleomagnetic studies is the lack of an empirical law relating a CRM characterized using non‐heating methods and the magnetizing field intensity. This issue is usually bypassed using the empirical law for non‐heating methods calibrated for thermoremanent magnetizations (TRM), resulting in poorly constrained paleointensities. Here, we determine such an empirical law through a series of CRM acquisition experiments. Magnetite is grown in weakly magnetic sedimentary rocks and synthetic samples in a magnetic field while heated at 350°C for 5 hr in an argon atmosphere. All samples exhibit a high‐coercivity magnetization parallel and proportional to the field applied, identified as a CRM carried by magnetite. We determine the CRM empirical law by retrieving the applied field intensity using non‐heating methods. The empirical coefficients differ from the TRM ones by a factor of 1.9–3.2 depending on the method. We use these coefficients to revisit the paleointensities published for the CM chondrite Murchison and the C2 ungrouped Tagish Lake. This empirical law opens the door to the study of numerous magnetite‐bearing meteorites potentially carrying a CRM.
The role of cellular and molecular neuroimmune crosstalk in gut immunity
Authors: Yang Daping , Almanzar Nicole , Chiu Isaac M. 
Published: June 2023

AbstractThe gastrointestinal tract is densely innervated by the peripheral nervous system and populated by the immune system. These two systems critically coordinate the sensations of and adaptations to dietary, microbial, and damaging stimuli from the external and internal microenvironment during tissue homeostasis and inflammation. The brain receives and integrates ascending sensory signals from the gut and transduces descending signals back to the gut via autonomic neurons. Neurons regulate intestinal immune responses through the action of local axon reflexes or through neuronal circuits via the gut-brain axis. This neuroimmune crosstalk is critical for gut homeostatic maintenance and disease resolution. In this review, we discuss the roles of distinct types of gut-innervating neurons in the modulation of intestinal mucosal immunity. We will focus on the molecular mechanisms governing how different immune cells respond to neural signals in host defense and inflammation. We also discuss the therapeutic potential of strategies targeting neuroimmune crosstalk for intestinal diseases.
Preimplantation genetic testing for Neurofibromatosis type 1: more than 20 years of clinical experience
Authors: Vernimmen Vivian , Paulussen Aimée D. C. , Dreesen Jos C. F. M. , van Golde Ron J. , Zamani Esteki Masoud , Coonen Edith , van Buul-van Zwet Marianne L. , Homminga Irene , Derijck Alwin A. H. A. , Brandts Lloyd , Stumpel Constance T. R. M. , de Die-Smulders Christine E. M. 
Published: June 2023

AbstractNeurofibromatosis type 1 (NF1) is an autosomal dominant disorder that affects the skin and the nervous system. The condition is completely penetrant with extreme clinical variability, resulting in unpredictable manifestations in affected offspring, complicating reproductive decision-making. One of the reproductive options to prevent the birth of affected offspring is preimplantation genetic testing (PGT). We performed a retrospective review of the medical files of all couples (n = 140) referred to the Dutch PGT expert center with the indication NF1 between January 1997 and January 2020. Of the couples considering PGT, 43 opted out and 15 were not eligible because of failure to identify the underlying genetic defect or unmet criteria for in vitro fertilization (IVF) treatment. The remaining 82 couples proceeded with PGT. Fertility assessment prior to IVF treatment showed a higher percentage of male infertility in males affected with NF1 compared to the partners of affected females. Cardiac evaluations in women with NF1 showed no contraindications for IVF treatment or pregnancy. For 67 couples, 143 PGT cycles were performed. Complications of IVF treatment were not more prevalent in affected females compared to partners of affected males. The transfer of 174 (out of 295) unaffected embryos led to 42 ongoing pregnancies with a pregnancy rate of 24.1% per embryo transfer. There are no documented cases of misdiagnosis following PGT in this cohort. With these results, we aim to provide an overview of PGT for NF1 with regard to success rate and safety, to optimize reproductive counseling and PGT treatment for NF1 patients.
Genetic characterization of non-5q proximal spinal muscular atrophy in a French cohort: the place of whole exome sequencing
Authors: Theuriet Julian , Fernandez-Eulate Gorka , Latour Philippe , Stojkovic Tanya , Masingue Marion , Vidoni Léo , Bernard Emilien , Jacquier Arnaud , Schaeffer Laurent , Salort-Campana Emmanuelle , Chanson Jean-Baptiste , Pakleza Aleksandra Nadaj , Kaminsky Anne-Laure , Svahn Juliette , Manel Véronique , Bouhour Françoise , Pegat Antoine 
Published: June 2023

AbstractProximal spinal muscular atrophy (SMA) is defined by a degeneration of the anterior horn cells resulting in muscle weakness predominantly in the proximal lower limbs. While most patients carry a biallelic deletion in the SMN1 gene (localized in chromosome 5q), little is known regarding patients without SMN1-mutation, and a genetic diagnosis is not always possible. Here, we report a cohort of 24 French patients with non-5q proximal SMA from five neuromuscular centers who all, except two, had next-generation sequencing (NGS) gene panel, followed by whole exome sequencing (WES) if gene panel showed a negative result. The two remaining patients benefited directly from WES or whole genome sequencing (WGS). A total of ten patients with causative variants were identified, nine of whom were index cases (9/23 families = 39%). Eight variants were identified by gene panel: five variants in DYNC1H1, and three in BICD2. Compound heterozygous causative variants in ASAH1 were identified directly by WES, and one variant in DYNC1H1 was identified directly by WGS. No causative variant was found using WES in patients with a previous panel with negative results (14 cases). We thus recommend using primarily NGS panels in patients with non-5q-SMA and using WES, especially when several members of the same family are affected and/or when trio analyses are possible, or WGS as second-line testing if available.
Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations
Authors: Ahmad Katya , Javed Abid , Lanphere Conor , Coveney Peter V. , Orlova Elena V. , Howorka Stefan 
Published: June 2023

AbstractDNA can be folded into rationally designed, unique, and functional materials. To fully realise the potential of these DNA materials, a fundamental understanding of their structure and dynamics is necessary, both in simple solvents as well as more complex and diverse anisotropic environments. Here we analyse an archetypal six-duplex DNA nanoarchitecture with single-particle cryo-electron microscopy and molecular dynamics simulations in solvents of tunable ionic strength and within the anisotropic environment of biological membranes. Outside lipid bilayers, the six-duplex bundle lacks the designed symmetrical barrel-type architecture. Rather, duplexes are arranged in non-hexagonal fashion and are disorted to form a wider, less elongated structure. Insertion into lipid membranes, however, restores the anticipated barrel shape due to lateral duplex compression by the bilayer. The salt concentration has a drastic impact on the stability of the inserted barrel-shaped DNA nanopore given the tunable electrostatic repulsion between the negatively charged duplexes. By synergistically combining experiments and simulations, we increase fundamental understanding into the environment-dependent structural dynamics of a widely used nanoarchitecture. This insight will pave the way for future engineering and biosensing applications.
Asynchronous locking in metamaterials of fluids of light and sound
Authors: Chafatinos D. L. , Kuznetsov A. S. , Reynoso A. A. , Usaj G. , Sesin P. , Papuccio I. , Bruchhausen A. E. , Biermann K. , Santos P. V. , Fainstein A. 
Published: June 2023

AbstractLattices of exciton-polariton condensates represent an attractive platform for the study and implementation of non-Hermitian bosonic quantum systems with strong non-linear interactions. The possibility to actuate on them with a time dependent drive could provide for example the means to induce resonant inter-level transitions, or to perform Floquet engineering or Landau-Zener-Stückelberg state preparation. Here, we introduce polaromechanical metamaterials, two-dimensional arrays ofμm-sized traps confining zero-dimensional light-matter polariton fluids and GHz phonons. A strong exciton-mediated polariton-phonon interaction induces a time-dependent inter-site polariton couplingJ(t) with remarkable consequences for the dynamics. When locally perturbed by continuous wave optical excitation, a mechanical self-oscillation sets-in and polaritons respond by locking the energy detuning between neighbor sites at integer multiples of the phonon energy, evidencing asynchronous locking involving the polariton and phonon fields. These results open the path for the coherent control of dissipative quantum light fluids with hypersound in a scalable platform.
Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling
Authors: Roy Michael J. , Surudoi Minglyanna G. , Kropp Ashleigh , Hou Jianmei , Dai Weiwen , Hardy Joshua M. , Liang Lung-Yu , Cotton Thomas R. , Lechtenberg Bernhard C. , Dite Toby A. , Ma Xiuquan , Daly Roger J. , Patel Onisha , Lucet Isabelle S. 
Published: June 2023

AbstractPEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their expression level is associated with several aggressive cancers. Here, we elucidate the molecular details of key PEAK signaling interactions with the adapter proteins CrkII and Grb2 and the scaffold protein 14-3-3. Our findings rationalize why the dimerization of PEAK proteins has a crucial function in signal transduction and provide biophysical and structural data to unravel binding specificity within the PEAK interactome. We identify a conserved high affinity 14-3-3 motif on PEAK3 and demonstrate its role as a molecular switch to regulate CrkII binding and signaling via Grb2. Together, our studies provide a detailed structural snapshot of PEAK interaction networks and further elucidate how PEAK proteins, especially PEAK3, act as dynamic scaffolds that exploit adapter proteins to control signal transduction in cell growth/motility and cancer.