bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conformational analysis of membrane-proximal segments of GDAP1 in a lipidic environment using synchrotron radiation suggests a mode of assembly at the mitochondrial outer membrane
Authors: Sutinen Aleksi , Jones Nykola C. , Hoffmann Søren Vrønning , Ruskamo Salla , Kursula Petri 
Published: May 2023

ABSTRACTThe mitochondrial outer membrane creates a diffusion barrier between the cytosol and mitochondrial intermembrane space, allowing the exchange of metabolic products, important for efficient mitochondrial function in neurons. The ganglioside-induced differentiation-associated protein 1 (GDAP1) is a mitochondrial outer membrane protein with a critical role in mitochondrial dynamics and metabolic balance in neurons. Missense mutations in theGDAP1gene are linked to the most common human peripheral neuropathy, Charcot-Marie-Tooth disease (CMT). GDAP1 is a distant member of the glutathione-S-transferase (GST) superfamily, with unknown enzymatic properties or functions at the molecular level. The structure of the cytosol-facing GST-like domain has been described, but there is no consensus on how the protein interacts with the mitochondrial outer membrane. Here, we describe a model for GDAP1 assembly on the membrane using peptides vicinal to the GDAP1 transmembrane domain. We used oriented circular dichroism spectroscopy (OCD) with synchrotron radiation to study the secondary structure and orientation of GDAP1 segments at the outer and inner surfaces of the outer mitochondrial membrane. These experiments were complemented by small-angle X-ray scattering, providing the first experimental structural models for full-length human GDAP1. The results indicate that GDAP1 is bound into the membraneviaa single transmembrane helix, flanked by two peripheral helices interacting with the outer and inner leaflet of the mitochondrial outer membrane in different orientations. Impairment of such interactions could be a mechanism for CMT in the case of missense mutations affecting these segments instead of the GST-like domain.
The paradoxical effect of perceived organizational politics on employees motivation: the mediation role of hostility and moderating role of organizational injustice
Authors: Nazir Sajjad , Khadim Sahar , Asadullah Muhammad Ali , Syed Nausheen 
Published: May 2023

PurposeThis research aims to unpack the relationship between employees' perceived organizational politics (POP) and their self-determined motivation by itemizing the mediating role of hostility and a moderating role of organizational injustice.Design/methodology/approachData were collected at two different times from 270 employees working in various universities in Pakistan. Structural equation modeling (SEM) was used to test the hypotheses.FindingsThe findings revealed that POP negatively influence intrinsic motivation, autonomous extrinsic motivation and positively impact amotivation, whereas POP does not affect employees' controlled extrinsic motivation. Furthermore, POP positively influences hostility. Moreover, hostility mediates the relationships between perceived organizational politics and self-determined motivation. Finally, the findings also revealed that the relationship between perceived organizational politics and hostility was stronger when the perceived organizational injustice was high.Practical implications POP can lead to intentional efforts to harm the organization by enhancing employee hostility, which divulges how this peril can be restrained by implanting organizational fairness. Moreover, proactive employees with superior emotional intelligence skills have a greater capability to control their negative emotions. Emotional intelligence (EI) training can effectively reduce the hostility between employees provoked by POP and ultimately diminish self-determined motivation.Originality/valueThe current study revealed that ambiguous forms of political behavior trigger isolated work emotions, negatively affecting organizational sustainability and outcomes. These results have valuable suggestions regarding organizational injustice as a moderator to diminish the hostility resulting from POP.
Older adult's commercial diffusion of household sector innovation: a vocational and retirement perspective
Authors: Yu Xin 
Published: May 2023

PurposeCitizens can develop new products in the household sector (HHS), and although HHS innovations are generally valuable to others, they are seldom diffused by the innovator. In order to provide insight for the understanding of this diffusion failure, this article proposes to introduce the vocational and retirement perspective to consider how the innovator's chronological aging affects her diffusion channel selection. Commercial diffusion of HHS innovations allows older adults to continue a work-related identity. And, a satisfying work experience could enhance older adults' reliance on work for self-worth. Therefore, the relationship between the older HHS innovators and their commercial diffusion as well as the moderating effect of their person–organization (P–O) fit on this relationship was examined.Design/methodology/approachThis study referred to the standard procedure and utilized a Japanese consumer panel to identify HHS innovators. The criterion of old age was set to 60+ years old. The hypotheses were tested with ordinary least squares regression analysis. The robustness of our findings was checked by analyzing two restricted samples.FindingsIn Japan, older adults are more likely to diffuse their HHS innovators commercially than to peers. This relationship is amplified when the older adults also perceived a P-O fit in their employer firm.Originality/valueThis paper adds to the evidence that older adults can be an important source of innovation. It – for the first time – points out that the vocational and retirement perspective can help researchers consider why a particular diffusion channel is selected and thereby provide insight for understanding when the diffusion failure of HHS innovation is alleviated. The moderating effect of the P–O fit originally suggests the “interdependent life spheres”, that is, older adults' work experience may affect their post-retirement life and their activity in the household sector.
Future of work – apprehensions and excitement of management graduates
Authors: P.M. Nimmi , Mukundan Smarty P. , Jose Geetha , Tesi Alessio , Alias Reena 
Published: May 2023

PurposeThe study explores the perceptions of graduates on their employability and future of work, in light of the challenges thrown upon by new vicissitudes in the work environment. The study intends to assess the preparedness of management graduates in facing the challenges and uncertainties of the actual job market.Design/methodology/approachSemi-structured and informal interviews with 65 management graduates from UK, Canada, Italy and India. The thematic analysis uncovered the concerns and areas to develop for management graduates regarding their future employability perceptions.FindingsThe authors benefited from a unique opportunity to capture the views and experience of graduates who are undergoing management education during this ambiguous period. Three major themes were developed on how to develop oneself for an ambiguous future of work which includes Psychological strengths, Skill enhancement and Future mindset. The study also unearthed the major focus areas for better employability from a graduate perspective.Practical implicationsPractical contribution comes from strategies to prepare university graduates for sustainable careers. Study hints at the importance of work experience, adaptability and skill enhancement in meeting the challenges of the future.Originality/valueFrom a global approach this is one among the first studies to look into the graduate perspective of their preparedness for future work.
Transitions in daily search tactics: during the cross-app interaction search process
Authors: Chen Jing , Chen Hongli , Li Yingyun 
Published: May 2023

PurposeCross-app interactive search has become the new normal, but the characteristics of their tactic transitions are still unclear. This study investigated the transitions of daily search tactics during the cross-app interaction search process.Design/methodology/approachIn total, 204 young participants' impressive cross-app search experiences in real daily situations were collected. The search tactics and tactic transition sequences in their search process were obtained by open coding. Statistical analysis and sequence analysis were used to analyze the frequently applied tactics, the frequency and probability of tactic transitions and the tactic transition sequences representing characteristics of tactic transitions occurring at the beginning, middle and ending phases. FindingsCreating the search statement (Creat), evaluating search results (EvalR), evaluating an individual item (EvalI) and keeping a record (Rec) were the most frequently applied tactics. The frequency and probability of transitions differed significantly between different tactic types. “Creat? EvalR? EvalI? Rec” is the typical path; Initiate the search in various ways and modifying the search statement were highlighted at the beginning phase; iteratively creating the search statement is highlighted in the middle phase; Moreover, utilization and feedback of information are highlighted at the ending phase. Originality/valueThe present study shed new light on tactic transitions in the cross-app interactive environment to explore information search behaviour. The findings of this work provide targeted suggestions for optimizing APP query, browsing and monitoring systems.
Open-source 3-D printing materials database generator
Authors: Choppara Dheeraj , Garmulewicz Alysia , Pearce Joshua M. 
Published: May 2023

PurposeThis study aims to apply an open-source approach to protect the 3D printing industry from innovation stagnation due to broad patenting of obvious materials.Design/methodology/approachTo do this, first an open-source implementation of the first five conditions of an open-source algorithm developed to identify all obvious 3-D printing materials was implemented in Python, and the compound combinations of two and three constituents were tested on ten natural and synthetic compounds. The time complexity for combinations composed of two constituents and three constituents is determined to be O(n2) and O(n3), respectively.FindingsGenerating all combinations of materials available on the Chemical Abstracts Services (CAS) registry on the fastest processor on the market will require at least 73.9 h for the latter, but as the number of constituents increases the time needed becomes prohibitive (e.g. 3 constituents is 1.65 million years). To demonstrate how machine learning (ML) could help prioritize both theoretical as well as experimental efforts a three-part biomaterial consisting of water, agar and glycerin was used as a case study. A decision tree model is trained with the experimental data and is used to fill in missing physical properties, including Young's modulus and yield strength, with 84.9 and 85.1% accuracy, respectively.Originality/valueThe results are promising for an open-source system that can theoretically generate all possible combinations of materials for 3-D printing that can then be used to identify suitable printing material for specific business cases based on desired material properties.
Remotely sensed environmental data as ecological proxies for ground‐dwelling ant diversity along a subtropical forest succession gradient
Authors: Lee Roger H. , Kwong Ivan H. Y. , Tsang Toby P. N. , Wong Mark K. L. , Guénard Benoit 
Published: May 2023

Abstract

Early naturalists such as Humboldt observed that changes in topography and anthropogenic disturbances influenced vegetation structure and the composition of animal communities. This holistic view of community assembly continues to shape conservation and restoration strategies in an era of landscape degradation and biodiversity loss. Today, remote sensing affords ecologists the tools for obtaining rapid and precise measures of topography, disturbance history and vegetation structure. Nonetheless, the capacity of such measures to predict the structure of diverse and functionally important insect communities has not been fully explored.

We sampled ground‐dwelling ant assemblages with pitfall traps along a successional gradient (15 grasslands, 21 shrublands and 44 forests) in subtropical Asia, and measured the taxonomic (TD) and functional diversity (FD). We used airborne Light Detection and Ranging (LiDAR) and aerial photography—to measure topography, anthropogenic‐fire history and vegetation structure at each site. Using structural equation models, we tested the hypothesis that vegetation structure mediated the effects of topography and anthropogenic‐fire history on ant assemblage TD and FD, with stronger effects on the latter.

We found that low elevation and anthropogenic‐fire history promoted ant TD, and by mediating vegetation structure, these factors further controlled ant FD. Specifically, assemblages of ant species occupying more similar niches—as indicated by their lower FD—were found in secondary forests that had more structurally homogeneous vegetation. These sites also had low insolation and high water moisture content, and were not recently burned as revealed by LiDAR‐derived metrics and aerial images. Furthermore, remotely sensed vegetation structures were closely associated with individual ant traits, such as body size and eye length, which reflect species' preferences for habitat structure.

Synthesis. Our study uncovers the interactive effects of topography, disturbance history and vegetation structure in determining the TD and FD of ant assemblages in subtropical landscapes. Moreover, it demonstrates that remote sensed data can be leveraged to efficiently elucidate the complex effects of environmental change and disturbances on vegetation structure and consequently insect biodiversity, representing ecological proxies to refine ground investigation plans and support appropriate conservation and restoration measures for degraded landscapes.
Cross‐Country Analysis of HRM Parameters in Emerging Markets: An Assessment of Measurement Invariance
Authors: Darwish Tamer K. , Singh Satwinder , Batsakis Georgios , Potočnik Kristina 
Published: May 2023

AbstractIn this paper we aim to critically discuss the challenges and benefits of using survey instruments (SIs) by measuring human resource management (HRM) parameters across five emerging markets – Brunei Darussalam, India, Jordan, Kingdom of Saudi Arabia and United Arab Emirates. In so doing, we proceed to an assessment of the measurement invariance of HRM parameters measured by SIs across these five countries. Based on our field experience and empirical results showing lack of measurement invariance across these five national contexts, we provide recommendations for conducting comparative analysis of HRM parameters in emerging markets, ultimately contributing to the HRM convergence–divergence debate in this type of national context.
Making Modern Mughals: Gendered Labour, Colonial Governance and the Household in Colonial India
Authors: Narayan Rochisha 
Published: May 2023

AbstractBritish officials in India disparaged the Mughal zanana to construct a linear argument on progress from a decadent Mughal past to the modern colonial period. This discourse was accompanied by the systematic marginalisation of Mughals under British rule, especially after the Rebellion of 1857. This article complicates tropes about the Mughal zanana and offers a historical perspective on late Mughal households. Using the colonial archive on Mughal genealogies, pensions and petitions, and educational records and scholarships, it illuminates how Mughal women confounded the teleology in colonial narratives. It demonstrates how Mughal women, of varying status and rank, fostered a tenuous modernity by weaving Mughal pasts into their present. Weighed against colonial attempts to gradually bring about the erasure of Mughal identity, this article suggests that these women's efforts to raise new generations of Mughals can be read as quotidian political acts.
Neonatal mortality risk for vulnerable newborn types in 15 countries using 125.5 million nationwide birth outcome records, 2000–2020
Authors: Suárez‐Idueta Lorena , Blencowe Hannah , Okwaraji Yemisrach B , Yargawa Judith , Bradley Ellen , Gordon Adrienne , Flenady Vicki , Paixao Enny S. , Barreto Mauricio L. , Lisonkova Sarka , Wen Qi , Velebil Petr , Jírová Jitka , Horváth‐Puhó Erzsebet , Sørensen Henrik Toft , Sakkeus Luule , Abuladze Liili , Yunis Khalid A. , Al Bizri Ayah , Barranco Arturo , Broeders Lisa , van Dijk Aimée E. , Alyafei Fawziya , Olukade Tawa O. , Razaz Neda , Söderling Jonas , Smith Lucy K. , Draper Elizabeth S. , Lowry Estelle , Rowland Neil , Wood Rachael , Monteath Kirsten , Pereyra Isabel , Pravia Gabriella , Ohuma Eric O. , Lawn Joy E. ,   the National Vulnerable Newborn Mortality Collaborative Group and Vulnerable Newborn Measurement Core Group
Published: May 2023

AbstractObjectiveTo compare neonatal mortality associated with six novel vulnerable newborn types in 125.5 million live births across 15 countries, 2000–2020.DesignPopulation‐based, multi‐country study.SettingNational data systems in 15 middle‐ and high‐income countries.MethodsWe used individual‐level data sets identified for the Vulnerable Newborn Measurement Collaboration. We examined the contribution to neonatal mortality of six newborn types combining gestational age (preterm [PT] versus term [T]) and size‐for‐gestational age (small [SGA], <10th centile, appropriate [AGA], 10th–90th centile or large [LGA], >90th centile) according to INTERGROWTH‐21st newborn standards. Newborn babies with PT or SGA were defined as small and T + LGA was considered as large. We calculated risk ratios (RRs) and population attributable risks (PAR%) for the six newborn types.Main outcome measuresMortality of six newborn types.ResultsOf 125.5 million live births analysed, risk ratios were highest among PT + SGA (median 67.2, interquartile range [IQR] 45.6–73.9), PT + AGA (median 34.3, IQR 23.9–37.5) and PT + LGA (median 28.3, IQR 18.4–32.3). At the population level, PT + AGA was the greatest contributor to newborn mortality (median PAR% 53.7, IQR 44.5–54.9). Mortality risk was highest among newborns born before 28 weeks (median RR 279.5, IQR 234.2–388.5) compared with babies born between 37 and 42 completed weeks or with a birthweight less than 1000 g (median RR 282.8, IQR 194.7–342.8) compared with those between 2500 g and 4000 g as a reference group.ConclusionPreterm newborn types were the most vulnerable, and associated with the highest mortality, particularly with co‐existence of preterm and SGA. As PT + AGA is more prevalent, it is responsible for the greatest burden of neonatal deaths at population level.
Successful use of subcutaneous anakinra in hemophagocytic lymphohistiocytosis precipitated by candidiasis in a patient with systemic lupus erythematosus: A case report and description of a novel therapeutic regimen
Authors: Xu Gary , Islam Sadia Tasnim , Makarie‐Rofail Lydia , Barnsley Les , Limaye Sandhya 
Published: May 2023

AbstractHemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal condition characterized by inappropriate immune system activation leading to a “cytokine storm”, and ultimately resulting in end‐organ damage. Causes include primary defects in genes involved in immune‐mediated cytolytic pathways, or secondary triggers such as infection or malignancy. We describe a case of HLH precipitated by fungal infection which occurred as a consequence of immunosuppression for management of systemic lupus erythematosus (SLE) and necrotizing myopathy. The patient presented with immune‐mediated disease of the muscles and lung which was treated with high‐dose corticosteroids and aggressive immunosuppression. HLH emerged in the context of confirmed candidiasis and features of severe sepsis. The patient responded rapidly to antifungal therapy and high‐dose anakinra, which was administered subcutaneously and progressively weaned over 4 weeks. She completed HLH treatment as an outpatient and remains well at 12 months with controlled SLE and no recurrence of HLH.
High‐affinity amide‐lanthanide adsorption to gram‐positive soil bacteria
Authors: Chang Elliot , Lammers Laura N. , Pallud Céline 
Published: May 2023

AbstractThe gram‐positive soil bacterium, Arthrobacter nicotianae, uses multiple organic acid functional groups to adsorb lanthanides onto its cell surface. At relevant soil pH conditions of 4.0–6.0, many of these functional groups are de‐protonated and available for cation sorption and metal immobilization. However, among the plethora of naturally occurring site types, A. nicotianae is shown to possess high‐affinity amide and phosphate sites that disproportionately affect lanthanide adsorption to the cell wall. We quantify neodymium (Nd)‐selective site types, reporting an amide‐Nd stability constant of log10K = 6.41 ± 0.23 that is comparable to sorption via phosphate‐based moieties. These sites are two to three orders of magnitude more selective for Nd than the adsorption of divalent metals to ubiquitous carboxyl‐based moieties. This implies the importance of lanthanide biosorption in the context of metal transport in subsurface systems despite trace concentrations of lanthanides found in the natural environment.
The policy response to global value chain disruption
Authors: Dadush Uri 
Published: May 2023

AbstractThis article considers how policymakers should react to the disruption of Global Value Chains, which became dramatically evident during the pandemic. It argues that repeated shocks to GVCs, as seen in recent years, are not purely random and disjointed events. They are the result of fundamental shifts in the geopolitical environment, global economy, and climate. Firms have concluded that international supply chains have become endemically riskier, and this is changing their risk/efficiency calculus. But there is no reason and – so far – little evidence to suggest that GVCs will stage a large‐scale retreat. Powerful economic forces are at work that will prompt increased reliance on GVCs and improve their operability in the future. Governments tend to overreact when faced with supply shocks, and unnecessarily impede GVCs; more nuanced and coordinated responses are needed. The WTO can play an important role, promoting the resilience of GVCs.
Piezo1 opposes age‐associated cortical bone loss
Authors: Li Xuehua , Zhang Connie , Bowman Hayden H. , Stambough Jeffrey B. , Stronach Benjamin M. , Mears Simon C. , Barnes Lowry C. , Ambrogini Elena , Xiong Jinhu 
Published: May 2023

AbstractAs we age, our bones undergo a process of loss, often accompanied by muscle weakness and reduced physical activity. This is exacerbated by decreased responsiveness to mechanical stimulation in aged skeleton, leading to the hypothesis that decreased mechanical stimulation plays an important role in age‐related bone loss. Piezo1, a mechanosensitive ion channel, is critical for bone homeostasis and mechanotransduction. Here, we observed a decrease in Piezo1 expression with age in both murine and human cortical bone. Furthermore, loss of Piezo1 in osteoblasts and osteocytes resulted in an increase in age‐associated cortical bone loss compared to control mice. The loss of cortical bone was due to an expansion of the endosteal perimeter resulting from increased endocortical resorption. In addition, expression of Tnfrsf11b, encoding anti‐osteoclastogenic protein OPG, decreases with Piezo1 in vitro and in vivo in bone cells, suggesting that Piezo1 suppresses osteoclast formation by promoting Tnfrsf11b expression. Our results highlight the importance of Piezo1‐mediated mechanical signaling in protecting against age‐associated cortical bone loss by inhibiting bone resorption in mice.