bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leaf-level coordination principles propagate to the ecosystem scale
Authors: Gomarasca Ulisse , Migliavacca Mirco , Kattge Jens , Nelson Jacob , Niinemets Ülo , Wirth Christian , Cescatti Alessandro , Bahn Michael , Nair Richard , Acosta Alicia , Arain Altaf , Beloiu Mirela , Black Thomas , Bruun Hans Henrik , Bucher Franziska , Buchmann Nina , Carrara Arnaud , Byun Chaeho , Conte Adriano , Silva Ana da , Duveiller Gregory , Fares Silvano , Ibrom Andreas , Knohl Alexander , Komac Benjamin , Limousin Jean-Marc , Lusk Christopher , Mahecha Miguel , Martini David , Minden Vanessa , Montagnani Leonardo , Mori Akira , Onoda Yukuke , Penuelas Josep , Perez-Priego Oscar , Poschlod Peter , Powell Thomas , Reich Peter , Šigut Ladislav , Bodegom Peter van , Walther Sophia , Wohlfahrt Georg , Wright Ian , Reichstein Markus 
Published: January 2023

Abstract
Fundamental axes of variation in plant traits result from trade-offs between costs and benefits of resource-use strategies at the leaf scale. However, it is unclear whether trade-offs and optimality principles in functional traits of leaves are conserved at the ecosystem level.
We tested three well-known leaf- and plant-level coordination theories at the ecosystem scale: the leaf economics spectrum, the global spectrum of plant form and function, and the least-cost hypothesis. We combined ecosystem functional properties from 98 FLUXNET sites, vegetation properties, and ecosystem-level plant traits into three corresponding principal component analyses.
Coordination is conserved at the ecosystem scale. However, additional processes occur at the ecosystem level compared to the leaf scale, highlighting the importance of scale-emergent properties in understanding and predicting ecosystem behaviour. Evaluating the coordination of ecosystem functional properties supports the development of more realistic global dynamic vegetation models with critical empirical data, reducing the uncertainty of climate change projections.
Menstrual, fertility and psychological impacts after uterine compression sutures for postpartum hemorrhage: a prospective cohort study
Authors: Kwong Lee Ting , Wong Sai Fun , So Po Lam 
Published: January 2023

Abstract
Background
Uterine compression suture is an important conservative surgical technique in managing atonic postpartum hemorrhage. In this study, we aim to evaluate the subsequent menstrual, fertility and psychological outcomes after uterine compression sutures.
Methods
This was a prospective cohort study between 2009 and 2022 conducted in a tertiary obstetric unit (6000 deliveries per year) in Hong Kong SAR. Women with primary postpartum hemorrhage successfully treated with uterine compression sutures were followed-up in postnatal clinic for two years after delivery. Data on menstrual pattern were collected during each visit. Psychological impact after uterine compression suture was assessed using a standardized questionnaire. Subsequent pregnancies were identified by territory-wide computer registry and telephone interviews. Women with postpartum hemorrhage treated with uterotonic agents only were chosen as controls.
Results
In our cohort (n = 80), 87.9% of women had return of menses within six months after delivery. Regular monthly cycle was observed in 95.6% of women. Majority of women reported similar menstrual flow (75%), menstrual days (85.3%) and no change in dysmenorrhea status (88.2%) as compared before. Among eight (11.8%) women who reported hypomenorrhea after uterine compression sutures, two cases of Asherman’s syndrome were diagnosed. Among 23 subsequent pregnancies (16 livebirths), no significant differences in outcome were observed except more omental or bowel adhesions (37.5% vs 8.8%, p = 0.007), recurrence of hemorrhage (68.8% vs 7.5%, p < 0.001) and repeated compression sutures (12.5% vs 0%, p = 0.024) were seen in women with previous compression sutures. Over half of the couple declined future fertility after uterine compression sutures with 38.2% of women recalled unpleasant memories and 22.1% reported life-long adverse impact especially tokophobia.
Conclusion
Majority of women with history of uterine compression sutures had similar menstruation and pregnancy outcomes as compared to those who did not have sutures. However, they had higher intrapartum risk of visceral adhesions, recurrence of hemorrhage and repeated compression sutures next pregnancy. Furthermore, couple could be more susceptible to negative emotional impact.
General practitioners’ perspectives regarding early developmental surveillance for autism within the Australian primary healthcare setting: A qualitative study
Authors: Barbaro Josephine , Winata Teresa , Gilbert Melissa , Nair Radhika , Khan Feroza , Lucien Abbie , Islam Raisa , Masi Anne , Diaz Antonio Mendoza , Dissanayake Cheryl , Karlov Lisa , Descallar Joseph , Eastwood John , Hasan Iqbal , Jalaludin Bin , Kohlhoff Jane , Liaw Siaw-Teng , Lingam Raghu , Ong Natalie , Tam Chun Wah Michael , Woolfenden Susan , Eapen Valsamma 
Published: January 2023

Abstract

Background:Significant challenges remain in the early identification of child developmental conditions in the community. Implementing supports and services early in the life course has been shown to promote positive developmental outcomes for children at high likelihood of developmental conditions including autism. As part of a cluster randomised controlled trial, this study seeks to examine and compare the perspectives and experiences of Australian general practitioners (GPs) in relation to a digital developmental surveillance program for autism and usual care pathway, in general practice clinics.
Methods:A qualitative research methodology (semi-structured interviews and thematic analysis) was utilised in this study. All GPs from South Western Sydney (NSW) and Melbourne (Victoria) who participated in the main program (“GP Surveillance for Autism”) were invited to the interview. GPs who provided consent were interviewed either over online or in-person meeting. Interviews were audio-recorded, transcribed, and coded using NVivo12 software.Inductive interpretive approach was adopted and data were analysed thematically.
Results:Twenty-three GPs across the two sites (NSW: n=11; Victoria: n=12) agreed to be interviewed; data saturation had reached following this number of participants. Inductive thematic coding and analysis yielded nine major themes and highlighted common enablers such as the role of GPs in early identification and intervention, enhanced communication between clinicians/professionals, relationship-building with patients, and having standardised screening tools. Specific facilitators to the feasibility and acceptability of a digital screening program for the early identification of developmental conditions, including the early signs of autism, and encouraging research and education for GPs. However, several practical and socioeconomic barriers were identified, in addition to limited knowledge and uptake of child developmental screening tools as well as COVID-19 lockdown impacts. Common and specific recommendations involve supporting GPs in developmental/paediatrics training, streamlined screening process, and funding and resources in the primary healthcare services.
Conclusions: The study highlighted the need for practice and policy changes, including further training of GPs alongside sufficient time to complete developmental checks and appropriate financial remuneration through a Medicare billing item. Further research is needed on implementation and scale up of a national surveillance program for early identification of developmental conditions including autism.
WITHDRAWN: The overall impact on the daily life of people with disabilities in Mainland China: two cross-sectional studies
Authors: Wang Jiaojiao , Wei Yan , Xie Haixia , Xu Zihan , Wang Xinyu , Zeng Xuheng , Chang Fengshui 
Published: January 2023

Abstract
Background
COVID-2019 has become a public health crisis, and as a vulnerable group, people with disabilities (PWDs) might be more seriously affected. However, the overall impact of COVID-19 on PWDs is unclear in Mainland China. Thus, we aimed to analyze the overall impact on PWDs from the early remission stage to the regular control stage of the COVID-19 pandemic in Mainland China.
Methods
In March 2020 and March 2021, anonymous questionnaires were distributed in the WeChat group of the PWDs using a convenient sampling method. The personal and family characteristics, perceived risk of COVID-19 infection, and the overall impact of COVID-19 on daily life and medical services needs were collected. The descriptive analysis, chi-square test, and multiple logistic regression analysis were used.
Results
311 and 1083 PWDs were enrolled in 2020 and 2021, respectively. In 2020, 82.0% of the participants reported a negative impact on their daily life, and the proportion of big impact was 20.3%. In 2021, 73.1% of PWDs reported a negative impact on their daily life. Multivariate analysis found the impact on medical services needs was the common associated factor of the overall impact on daily life in 2020 and 2021, and PWDs with lower annual household income or chronic diseases were more likely to suffer bigger negative effects in 2020, while being in quarantine or not at work, having items in shortage and with less disability severity (without multiple disabilities or spinal cord injury) were the associated factors in 2021. Based on the matching method, we found that the overall impact on the daily life of PWDs decreased in 2021.
Conclusions
A majority of the PWDs reported a negative impact on their daily life in Mainland China at the early remission stage of the COVID-19 pandemic, and the impact has significantly weakened during the normal control period in 2021. It is recommended to fulfill the medical service needs of PWDs in a timely manner, and those being in quarantine or not at work, without SCI or multiple disabilities, and reporting some items in shortage suffered a bigger major overall COVID-19 impact on daily life.
Relationship between large-for-gestational age and hospital readmission after postpartum discharge
Authors: Nimal M , Ravel C , Nauleau S , Lapalus D , Bernard O , des Robert C , Tardieu S , Boubred F 
Published: January 2023

Abstract
Objective
To determine the association of small (SGA) and large (LGA) for gestational age at birth with hospital readmission after postpartum discharge for up to 28 days of delivery
Methods
Population-based linkage study using the French National Uniform Hospital Discharge Database. ‘Healthy’ singleton term infants born between January 1st, 2017 and November 30th, 2018 in the French South region were included. SGA and LGA were defined as birth weight < 10th and > 90th percentiles, respectively, according to sex and gestational age. A multivariable regression analysis was performed.
Results
Among 67,359 included infants, 2441 (3.6%) were re-admitted and 61% of them were hospitalized within 14 days postpartum. Hospitalized infants were more likely to be LGA at birth (10.3% vs. 8.6% in non-hospitalized infants, p < 0.01); the proportion of SGA infants did not differ between both groups. Compared to appropriate birth weight for GA (AGA) infants, LGA infants were more often hospitalized for infectious diseases (57.7% vs. 51.3%, p = 0.05). After regression analysis LGA infants had a 20% higher odds of being hospitalized than those born AGA (aOR(95%CI) = 1.21 (1.06–1.39)) while aOR(95%CI) for SGA was 1.11 (0.96–1.28).
Conclusions
In contrast to SGA, LGA was associated with hospital readmission during the first month of life. Follow-up protocols that include LGA should be evaluated.
An Eco-sustainable Innovative Geotechnical Technology for the Structures Seismic Isolation, Investigated by Fem Parametric Analyses
Authors: ABATE Glenda , Fiamingo Angela , Massimino Maria Rossella 
Published: January 2023

Abstract
Geotechnical Seismic Isolation (GSI) is an innovative technique for protecting structures in earthquake-prone areas. The main idea is to improve the foundation soil so that seismic energy is partially dissipated within GSI before being transmitted to the structure. Among other materials proposed for foundation soil improvement, gravel-rubber mixtures (GRMs), with rubber grains manufactured from end-of-life tires (ELTs), have attracted significant research interest thanks to their good mechanical properties. GRMs also represent a modern recycling system to reduce the stockpile of scrap tires worldwide.
The present study investigated numerically the effect of a GRM layer located underneath the shallow foundations of a real structure. The structure is a typical reinforced concrete building in southern Italy. A Finite Element Modelling (FEM) was carried out to evaluate the overall static and dynamic behaviour of the soil-GRMs-structure system. Three FEM models were performed with and without the GRM layer, varying the GRM layer thickness and the seismic inputs. The comparisons among the models allow us to assess the performance of the GRM underneath the foundations as a new eco-sustainable solution for the seismic isolation of structures.
Sociodemographic inequalities on women's behavioral and health outcomes: a population-based study
Authors: Meller Fernanda Oliveira , Miranda Vanessa Iribarrem Avena , Ceretta Luciane Bisognin , Quadra Micaela Rabelo , Tomasi Cristiane Damiani , Soratto Jacks , Maciel Elisabete Borges , Schäfer Antônio Augusto 
Published: January 2023

Abstract
Background: The inequality in access to women's basic rights can impact health conditions.
This study aimed to assess sociodemographic inequalities on women's behavioral and health outcomes.
Methods: A population-based cross-sectional study conducted in a city in the south of Brazil in 2019. Individuals aged ≥18 years, living in an urban area, were eligible. For this study, only women were included. The outcomes evaluated were worse health perception, overweight, systemic arterial hypertension (SAH), diabetes mellitus (DM), insufficient physical activity, poorer diet quality, smoking, and alcohol consumption. Inequalities were analyzed considering age, schooling, and income, through the complex index of inequality, and equiplot graphs were presented.
Results: Among the 523 women studied, a worse perception of health was found among the older adults, with lower income and schooling. SAH, DM, and poorer diet quality were more frequent in older women with less schooling. Those with less schooling were also more overweight and reported insufficient physical activity. Smoking and alcohol consumption were more frequent among younger women. Alcohol consumption was more frequent among those with a higher income and more schooling.
Conclusion: There is a need to strengthen the education system, as well as to implement policies for valorization and qualification of work, with a view to the opportunity for improvement and gender equity.
A microbiome survey of Tokaj highlights viticultural terroirs in Mád and suggests soil microbial contribution to must polyphenol contents
Authors: Remenyik Judit , Csige László , Dávid Péter , Fauszt Péter , Szilágyi-Rácz Anna Anita , Szőllősi Erzsébet , Bacsó Zsófia Réka , Jnr Istvan Szepsy , Molnár Krisztina , Rácz Csaba , Fidler Gábor , Kállai Zoltán , Stündl László , Dobos Attila Csaba , Paholcsek Melinda 
Published: January 2023

AbstractA Hungarian survey of Tokaj-Mád vineyards was conducted. Shot-gun metabarcoding was applied to decipher the microbial-terroir. The results of 60 soil samples showed that there were three dominant fungal phyla,Ascomycota66.36% ± 15.26,Basidiomycota18.78% ± 14.90,Mucoromycota11.89% ± 8.99, representing 97% operational taxonomic units (OTUs). Mutual interactions between microbiota diversity and soil physicochemical parameters were revealed. Principal component analysis showed descriptive clustering patterns of microbial taxonomy and resistance gene profiles in the case of the four historic vineyards (Szent Tamás, Király, Betsek, Nyúlászó). Soil seed bacteria changed markedly due to ripening. Network analyses were performed to unravel changes in fungal interactions when comparing postveraison and preharvest samples. In addition to the arbuscular mycorrhizaGlomeraceae, the familiesMycosphaerellacaeandRhyzopodaceaeand the classAgaricomyceteswere found to have important roles in maintaining soil microbial community resilience. By investigating the possible connections between the soil fungal community and the associated must samples, it was found that the species of theDiversisporagenus and the familyCordycipitaceaewere shown to be good soil indicator microorganisms of a high must polyphenol content. Functional metagenomics showed that the soil Na content stimulated several of the microbiota-related agrobiogeochemical cycles, such as nitrogen and sulphur metabolism; steroid, bisphenol, toluene, dioxin and atrazine degradation and the synthesis of folate.
Evaluation of pre-processing methods for tear fluid proteomics using the Olink platform
Authors: Vergouwen Daphne P.C. , Schotting Amber J. , Endermann Tanja , de Werken Harmen J.G. Van , Grashof Dwin G.B. , Arumugam Sinthuja , Nuijts Rudy M.M.A. , Berge Josianne C. ten , Rothova Aniki , Schreurs Marco W.J. , Gijs Marlies 
Published: January 2023

Abstract
Tear fluid forms a potential source for biomarker identification, and can be minimal invasively collected via Schirmer strips. The lack of knowledge on the processing of Schirmer strips however complicates the analysis and between-study comparisons. We studied two different pre-processing methods, specifically the use of punches of the strip versus elution of the strip in PBS buffer. Tear fluid filled Schirmer strips were collected from 5 healthy participants, and divided into two halves over the length of the strip. In either part, punches or eluates were obtained from 4 different locations, from the first part touching the eye (head) to the end, to assess the protein distribution along the strips. The levels of 92 inflammatory proteins were measured in the punches/eluates using Olink Target 96. The punch method yielded higher protein detectability compared to the elution method (76% vs 66%; p ≤ 0.001). However, 3 out of 5 punches from the head failed quality control. Protein levels over the remaining parts of the strips were similar. Based on our findings we encourage using the punch method of any part of the strip except the head with Olink Target 96 or other suitable techniques.
Evaluation of maternal serum lipid profiles and clinical chemistry parameters in the prediction of pre-eclampsia in pregnant women attending ANC and delivery services
Authors: Tesfa Endalamaw , Munshea Abaineh , Nibret Endalkachew , Mekonnen Daniel , Sinishaw Mulusew Alemneh , Gizaw Solomon Tebeje 
Published: January 2023

AbstractPre-eclampsia (PE) is a pregnancy related metabolic syndrome which adversely influence the mother and their newborn infants. Besides, lack of study in our population, some studies also reporting discrepancies in the association of lipid profiles and clinical chemistry parameters with the risk of PE. Hence, this study was designed to evaluate the diagnostic potential of serum lipid profiles and clinical chemistry parameters with PE. Institution-based case-control study was performed at Bahir Dar city governmental hospitals. The study participants were selected through simple random sampling and the socio-demographic data were collected by interview-administered questionnaire. Five ml of venous blood were collected to evaluate lipid profile and clinical chemistry parameters. Descriptive statistics, chi-squared test, multivariable logistic regression and Mann-Whitney U test were utilized for analysis of variables. ROC and combined ROC curve analysis were executed to check the diagnostic accuracy at 95% CI. A total of 336 study participants (168 cases and 168 controls) were included. The median concentrations of serum triglyceride (229 (180-293.75) vs 194 (158.5–255)), total cholesterol (196 (167.25–224) vs 185.5 (158.5-212.75)), ALT (23(20–32) vs 21 (20–25)) and AST (35 (23.25-45) vs 24 (20–35)) values were significantly increased in cases as compared with normal controls. However, the median concentrations of serum total protein (6.7(6.1–7.4) vs 7.1 (6.7–7.6)) and serum calcium (7.6 (7.1–7.9) vs 7.9(7.5–8.3)) were significantly decreased in cases than controls. Positive correlations were observed between blood pressure and serum levels of triglyceride, total cholesterol, ALT & AST values while negative correlations were shown between blood pressure and HDL-cholesterol, total protein and serum calcium values. The combined ROC curve analysis of serum lipid profiles and clinical chemistry parameters showed a moderate prediction potential of PE. Hence, serum lipid profiles and clinical chemistry parameters were utilized as the diagnostic biomarkers of PE. However, to generate tangible evidence on the roles of lipid profiles and clinical chemistry parameters in PE pathogenesis and to include them as routine diagnostic biomarker multi-center prospective studies will be warranted.
Machine Learning based on Computational Fluid Dynamics enables geometric design optimisation of the NeoVAD blades
Authors: Nissim Lee , Karnik Shweta , Smith Peter Alex , Wang Yaxin , Frazier Oscar Howard , Fraser Katharine 
Published: January 2023

Abstract
The NeoVAD is a proposed paediatric axial-flow Left Ventricular Assist Device (LVAD), small enough to be implanted in infants. The design of the impeller and diffuser blades is important for hydrodynamic performance and haemocompatibility of the pump. This study aimed to optimise the blades for pump efficiency using Computational Fluid Dynamics (CFD), machine learning and global optimisation.
Meshing of each design typically included ~6 million hexahedral elements and a Shear Stress Transport (SST) turbulence model was used to close the Reynolds Averaged Navier-Stokes (RANS) equations. CFD models of 32 base geometries, operating at 8 flow rates between 0.5 and 4 l/min, were created to match experimental studies. These were validated by comparison of the pressure-flow and efficiency-flow curves with those experimentally measured for all base prototype pumps.
A surrogate model was required to allow the optimisation routine to conduct an efficient search; a multi-linear regression, Gaussian Process Regression and a Bayesian Regularised Artificial Neural Network (BRANN) predicted the optimisation objective at design points not explicitly simulated. A Genetic Algorithm was used to search for an optimal design.
The optimised design offered a 5.51% increase in efficiency at design point (a 20.9% performance increase) as compared to the best performing pump from the 32 base designs.An optimisation method for the blade design of LVADs has been shown to work for a single objective function and future work will consider multi-objective optimisation.