bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Roda da Fortuna nos Dictats de Ausiàs March (c. 1397-1439)
Authors: Da Costa Ricardo , Coimbra Lemke Wilson 
Published: December 2022

Resumo: A alegoria da Roda da Fortuna é um tema recorrente no pensamento medieval, sobretudo na Filosofia e na Literatura. A noção de fortuna foi herdada de uma dupla tradição e adaptada por Ausiàs March (c. 1397-1439) para uso literário. A primeira fonte é antiga: greco-romana. Primeiro, Aristóteles (384-322 a.C.) começou a lhe arranjar um espaço na sua concepção filosófica e política (Física, II, 4-6; Política, V, 3). Depois, Políbio (200-120 a.C.), Tito Lívio (c. 59 a.C. - 17 d.C.) e Plutarco (46 - 120) analisaram sua influência na história. A segunda, medieval, é a da Consolação da Filosofia, de Boécio (c. 477-524). Trataremos dessa alegoria nos Dictats, de Ausiàs March, para mostrar como o poeta valenciano desenvolveu literariamente o tema da instabilidade da Roda da Fortuna em seus poemas.Palavras chave: Ausiàs March, Roda da Fortuna, Literatura.Abstract: The allegory of the Wheel of Fortune is a recurring theme in medieval thought, especially in Philosophy and Literature. The notion of fortune was inherited from a double tradition and adapted by Ausiàs March (c. 1397-1439) for literary use. The first source is ancient: Greco-Roman. First, Aristotle (384-322 BC) began to find a place for it in his philosophical and political conception (Physics, II, 4-6; Politics, V, 3). Afterwards, Polybius (200-120 BC), Livy (c. 59 BC - 17 AD) and Plutarch (46 - 120) analyzed its influence on history. The second, medieval, is the Consolation of Philosophy, by Boethius (c. 477-524). We will deal with this allegory in the Dictats, by Ausiàs March, to show how the Valencian poet literarily developed the theme of the instability of the Wheel of Fortune in his poems.Keywords: Ausiàs March, Wheel of Fortune, Literature.
Performance of CdS/TNTAs Nanocomposite in Removing Ciprofloxacin and Hydrogen Production using Simultaneously Electrocoagulation-Photocatalysis Process
Authors: Sugihartini Rahayu Lestari , Pratiwi Reno , Slamet Slamet 
Published: December 2022

This study used CdS as a pair of TiO2 Nanotube Arrays (TNTAs), considering the position and width of the energy band gap, which is expected to increase photocatalyst performance. The nancomposite was synthesized using the successive ionic layer adsorption reaction (SILAR) method, with Cd(CH3COO)2 and Na2S as precursors. The CdS/TNTAs nanocomposite is expected to reduce the energy band gap to enable the visible and UV spectrum to activate the photocatalyst. Additionally, the formed heterojunction mechanism provides opportunities for the trajectories of electrons and holes to be farther apart and reduce the recombination rate. The degradation ability of CdS/TNTAs nanocomposite in the photocatalytic process was evaluated using samples of ciprofloxacin liquid waste as an antibiotic, which is quite challenging to decompose completely. The ability of the photocatalytic process to produce hydrogen gas was also observed and its performance synergized with the electrocoagulation process. The result showed that the use of CdS as a TNTAs partner in CdS/TNTAs nanocomposites affects increasing photocatalyst performance, both in degrading ciprofloxacin and producing hydrogen gas. Furthermore, the CdS/TNTAs nanocomposite increased the photocatalytic process’s ability to degrade ciprofloxacin and produce hydrogen from 8.5 to 20.5% and 6 to 23.5 mmol/m2 compared to using TNTAs alone. The processing capability is further enhanced when run in synergy with the electrocoagulation process where the removal of ciprofloxacin reaches 86.55% and the hydrogen produced is 2.62×106 mmol/m2. Copyright © 2022 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).
Extending the EclipseTM AcurosXB output factor table for small field radiosurgery
Authors: Wu Ning Genevieve 
Published: December 2022

AbstractPurposeTo investigate the necessity of extending the output factor table (OF Table) of the Varian EclipseTM Treatment Planning System for small field stereotactic radiosurgery (SRS) and stereotactic body radiosurgery (SBRT) treatments.MethodsA new AcurosXB 15.6 beam model was created in the Eclipse Beam Configuration, which is identical to the one that has been used in the clinic with a default 3 × 3 cm to 40 × 40 cm OF Table, except the OF Table in the new model was extended to cover the range from 1 × 1 cm to 40 × 40 cm. 80 small square and rectangular output factors were measured on a Varian TrueBeam utilizing a Standard Imaging Exradin W2‐1×1 scintillator detector, inside a PTW BeamScan water tank with 95 cm SSD at 5 cm depth. Cerenkov contamination was corrected using a rectangular field method (2 cm × 15 cm field). Nine Radiosurgery plans with primary jaw setting ranging from 0.7 cm to 2.0 cm were evaluated by both beam models. The monitor unit (MU) differences between the two beam models were calculated for identical 3‐dimensional (3D) absolute dose distributions. Output factors, measured versus Eclipse calculated, were compared down to 0.5 × 0.5 cm primary jaw setting.ResultsFor the 6FFF beam, the difference between the two beam models was ∼ 6% for 1 × 1 cm jaw settings and 4% at 1.5 × 1.5 cm, with the extended OF Table requiring higher MUs for the same dose prescription and same 3‐dimensional isodose distribution. For the 6MV beam, the corresponding difference is ∼7.5% for 1 × 1 cm, 5% for 1.5 × 1.5 cm, and 3% for 2 × 2 cm jaw settings, with the extended OF Table requiring higher MUs. For jaw settings smaller than 1 × 1 cm, measured dose can be considerably smaller than Eclipse predicted dose, even with the OF Table extension. This is reflected by the fact that the output factor for 0.5 × 0.5 cm, calculated via Eclipse external beam, was more than 30% greater than that measured for both 6FFF and 6MV beams.ConclusionsEclipse does a satisfactory job for primary jaw sizes down to 2 cm. For jaw settings smaller than 1.5 cm, the OF Table in Eclipse should be extended to improve the dose calculation accuracy.
Two‐Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies
Authors: O'Halloran Seán , Pandit Abhay , Heise Andreas , Kellett Andrew 
Published: December 2022

AbstractTwo‐photon polymerization (TPP) has become a premier state‐of‐the‐art method for microscale fabrication of bespoke polymeric devices and surfaces. With applications ranging from the production of optical, drug delivery, tissue engineering, and microfluidic devices, TPP has grown immensely in the past two decades. Significantly, the field has expanded from standard acrylate‐ and epoxy‐based photoresists to custom formulated monomers designed to change the hydrophilicity, surface chemistry, mechanical properties, and more of the resulting structures. This review explains the essentials of TPP, from its initial conception through to standard operating principles and advanced chemical modification strategies for TPP materials. At the outset, the fundamental chemistries of radical and cationic polymerization are described, along with strategies used to tailor mechanical and functional properties. This review then describes TPP systems and introduces an array of commonly used photoresists including hard polyacrylic resins, soft hydrogel acrylic esters, epoxides, and organic/inorganic hybrid materials. Specific examples of each class—including chemically modified photoresists—are described to inform the understanding of their applications to the fields of tissue‐engineering scaffolds, micromedical, optical, and drug delivery devices.
On the true nature of the contact binary CRTS J192848.7‐404555
Authors: Wadhwa Surjit S. , DeHorta Ain Y. , Filipović Miroslav , Tothill Nick F. H. 
Published: December 2022

AbstractCRTS J192848.7‐404555 was recognized as a potential contact binary merger candidate on the basis of survey photometry analysis. We have carried out follow‐up ground‐based photometry of the system and showed that at the recorded coordinates for the system, there are two stars approximately 3 s of arc apart. Our analysis shows that the fainter of the two stars is the actual variable while the slightly brighter star is of fixed brightness. In addition, we show that the reported survey photometry is the result of both stars being treated as a single light source with resultant erroneous light curve solution. The true nature of CRTS J192848.7‐404555 shows it to be a low mass contact binary system with a high mass ratio of 0.425, high amplitude of 0.69 magnitude, and shallow 24% contact. The system does not have features of orbital instability and is not a potential merger progenitor.
Synthesis, characterization, and electrocatalytic behaviour of hydrothermally grown nanostructured La2O3 and La2O3/K‐complex
Authors: Srivastava Ankur , Mishra Gargi , Singh Kshitij RB , Singh Jay , Pandey Rampal , Pandey Mrituanjay D. 
Published: December 2022

AbstractRare earth metals play a conspicuous role in magnetic resonance imaging (MRI) for detecting cancerous cells. The alkali metal potassium is a neurotransmitter in the sodium–potassium pump in biomedical sciences. This unique property of rare earth metals and potassium drew our attention to carry forward this study. Therefore, in this work, previously synthesized potassium (K) complexes formed by the reflux of 4‐N,N‐dimethylaminobenzoic acid (DBA) and potassium hydroxide in methanol, and named [(μ2–4‐N,N‐dimethylaminobenzoate‐κO)(μ2–4‐N,N‐dimethylaminobenzoic acid‐κO)(4‐N,N‐dimethylaminobenzoic acid‐κO) potassium(I) coordination polymer)] were treated hydrothermally with La2O3 nanomaterials to obtain a nanohybrid La2O3/K‐complex. After that, the K‐complex was analyzed using single‐crystal X‐ray diffraction and 1H and 13C NMR spectroscopy. In addition, the structural and morphological properties of the as‐prepared nanostructured La2O3/K‐complex were also characterized, which involved an investigation using X‐ray diffraction (XRD)spectroscopy, Fourier transform infrared (FTIR) spectroscopy, atomic force spectroscopy (AFM), transmission electron microscopy (TEM), and energy dispersive X‐ray (EDX) analysis. After this, the electrochemical redox behaviour of the synthesized nanohybrid material was studied using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Therefore, the results from these studies revealed that the as‐prepared material was a La2O3/K‐complex that has a promising future role in sensing various analytes, as it showed effective electrocatalytic behaviour.
Redox‐metabolic reprogramming of skin in mice lacking functional Nrf2 under basal conditions and cold acclimation
Authors: Zakic Tamara , Stojanovic Sara , Jankovic Aleksandra , Korac Aleksandra , Pekovic‐Vaughan Vanja , Korac Bato 
Published: December 2022

AbstractAdaptive responses to environmental and physiological challenges, including exposure to low environmental temperature, require extensive structural, redox, and metabolic reprogramming. Detailed molecular mechanisms of such processes in the skin are lacking, especially the role of nuclear factor erythroid 2‐related factor 2 (Nrf2) and other closely related redox‐sensitive transcription factors Nrf1, Nrf3, and nuclear respiratory factor (NRF1). To investigate the role of Nrf2, we examined redox and metabolic responses in the skin of wild‐type (WT) mice and mice lacking functional Nrf2 (Nrf2 KO) at room (RT, 24 ± 1°C) and cold (4 ± 1°C) temperature. Our results demonstrate distinct expression profiles of major enzymes involved in antioxidant defense and key metabolic and mitochondrial pathways in the skin, depending on the functional Nrf2 and/or cold stimulus. Nrf2 KO mice at RT displayed profound alterations in redox, mitochondrial and metabolic responses, generally akin to cold‐induced skin responses in WT mice. Immunohistochemical analyses of skin cell compartments (keratinocytes, fibroblasts, hair follicle, and sebaceous gland) and spatial locations (nucleus and cytoplasm) revealed synergistic interactions between members of the Nrf transcription factor family as part of redox‐metabolic reprogramming in WT mice upon cold acclimation. In contrast, Nrf2 KO mice at RT showed loss of NRF1 expression and a compensatory activation of Nrf1/Nrf3, which was abolished upon cold, concomitant with blunted redox‐metabolic responses. These data show for the first time a novel role for Nrf2 in skin physiology in response to low environmental temperature, with important implications in human connective tissue diseases with altered thermogenic responses.
Bulky anion effect on the architecture of chiral dysprosium single‐molecule magnets
Authors: Douib Haiet , Dhbaibi Kais , Lefeuvre Bertrand , Dorcet Vincent , Guizouarn Thierry , Pointillart Fabrice 
Published: December 2022

AbstractThe interest for chiral tris(β‐diketonato)lanthanide complexes in coordination chemistry is huge due to its Lewis acid character, optical activity, and the control of the final compound architecture. The reaction of equimolar quantities of [Dy((−)/(+)hfc)3(H2O)] (hfc− = 3‐(heptafluoropropylhydroxymethylene)‐(+/−)‐camphorate) and L led to the formation of a pair of enantiomers for dinuclear complexes [Dy((−)/(+)hfc)3(L)]2⋅C7H16 ([(−)/(+)1]⋅C7H16) (L = 4′‐(4′′′‐pyridyl‐N‐oxide)‐1,2′:6′1′′‐bis‐(pyrazolyl)pyridine]). Starting from the previous experimental protocol with the addition of bulky BArF anions, a partial dissociation of the chiral [Dy((−)/(+)hfc)3(H2O)] was observed leading to the isolation of a mono‐dimensional cationic chiral polymer {[Dy((−)/(+)hfc)2(L)][BarF]}n⋅nCH3NO2 ([(−)/(+)2]n⋅nCH3NO2). Natural circular dichroism (NCD) highlighted an exciton CD couplet for [(−)/(+)2]n but not for (−)/(+)1. The latter behaves as a single‐molecule magnet (SMM) with a blocking temperature up to 4 K, whereas [(−)/(+)2]n is a 1D assembly of field‐induced SMMs with a magnetic relaxation occurring through a Raman process only.
Design and characterization of lipid nanocarriers for oral delivery of immunotherapeutic peptides
Authors: Calderón‐Colón Xiomara , Zhang Yichuan , Tiburzi Olivia , Wang Jialu , Hou Shenda , Raimondi Giorgio , Patrone Julia 
Published: December 2022

AbstractThe use of therapeutic proteins and peptides is of great interest for the treatment of many diseases, and advances in nanotechnology offer a path toward their stable delivery via preferred routes of administration. In this study, we sought to design and formulate a nanostructured lipid carrier (NLC) containing a nominal antigen (insulin peptide) for oral delivery. We utilized the design of experiments (DOE) statistical method to determine the dependencies of formulation variables on physicochemical particle characteristics including particle size, polydispersity (PDI), melting point, and latent heat of melting. The particles were determined to be non‐toxic in vitro, readily taken up by primary immune cells, and found to accumulate in regional lymph nodes following oral administration. We believe that this platform technology could be broadly useful for the treatment of autoimmune diseases by supporting the development of oral delivery‐based antigen specific immunotherapies.
Correlation of the degenerative stage of a disc with magnetic resonance imaging, chemical content, and biomechanical properties of the nucleus pulposus
Authors: Azril  , Huang Kuo‐Yuan , Hobley Jonathan , Rouhani Mehdi , Liu Wen‐Lung , Jeng Yeau‐Ren 
Published: December 2022

AbstractIntervertebral disc degeneration (IDD) is closely related to changes in the intervertebral disc (IVD) composition and the resulting viscoelastic properties. IDD is a severe condition because it decreases the disc's ability to resist mechanical loads. Our research aims to understand IDD at the cellular level, specifically the changes in the viscoelastic properties of the nucleus pulposus (NP), which are poorly understood. This study employed a system integrating nanoindentation with Raman spectrometry to correlate biomechanics with subtle changes in the biochemical makeup of the NP. The characterization was, in turn, correlated with the degenerative severity of IVD as assessed using magnetic resonance imaging (MRI) of different patients with spinal stenosis, degenerative spondylolisthesis, and degenerative scoliosis. It is shown that there is an increase in the crosslinking ratio in collagen, a reduction in proteoglycan, and a build‐up of minerals upon the rise in the severity level of the disc damage in the NP. Assessment of mechanical characteristics reveals that the increasing disc degeneration makes the NP lose its elasticity, becoming more viscous. This shows that the tissue undergoes abnormalities in weight‐bearing ability, which contributes to spinal instability. The correlation of the individual discs shows that grades III and IV have similarities in the changes of Amide I and III toward the storage modulus. In contrast, grades IV and V correlate with mineralization toward the storage modulus. Reduction of proteoglycan has the highest impact on the changes of the storage modulus in all grades of IDD. Connecting compositional alterations to IVD micromechanics at various degrees of degeneration expands our understanding of tissue behavior and provides critical insight into clinical diagnostics, treatment, and tissue engineering.
Professionalism and professional identity formation in dental students: Revisiting the professional role orientation inventory (PROI)
Authors: Smith Carlos S. , Stilianoudakis Spiro C. , Carrico Caroline K. 
Published: December 2022

AbstractObjectiveProfessionalism is a hallmark of health professions education. Professional identity formation is a growing field of exploration in medical education, and the dental literature is sparse on just how professional identity formation is developed and assessed within dental education.MethodsThe validated professional role orientation inventory (PROI) was administered to 2nd year dental students during a spring semester ethics course. The PROI includes four 10‐item scales representing four attitudinal factors: Authority, Responsibility, Agency, and Autonomy.ResultsWhen compared to a historical sample of dental students in the early 1990s, dental students today scored significantly higher on Responsibility (p = 0.0309) and lower on the Agency factor (p = 0.0001). Authority scores in the current sample of dental students were significantly associated with age and race, with an increase in age associated with a decrease in Authority (p = 0.0504) and Caucasian respondents demonstrating significantly higher scores than Asian or Other races. Debt was associated with differences in Autonomy (p = 0.0683) and Agency (p = 0.0106), with those in the 100k–300k anticipated debt range demonstrating lower levels of both Autonomy and Agency. Race was marginally associated with Responsibility with those in the Other race category (Hispanic, Black/African American, Other/Multiracial) demonstrating higher levels than Caucasian (p = 0.0513).ConclusionDental students' scores denote a continued commitment to others yet a feeling of less sense of control as a practicing professional. A redefining of professionalism to include social activism and advancing health equity is required given their altruism and commitment to others, which remains high.
Impact of peri‐implantitis on the proteome biology of crevicular fluid: A pilot study
Authors: Halstenbach Tim , Nelson Katja , Iglhaut Gerhard , Schilling Oliver , Fretwurst Tobias 
Published: December 2022

AbstractBackgroundThe proteome of the peri‐implant crevicular fluid (PICF) has not been systematically investigated. The aim of the present study was to reveal the proteome biology of dental implants affected with peri‐implantitis.MethodsPatients with at least one diseased implant were included (probing depth ≥6 mm, ≥3 mm peri‐implant radiological bone loss). Using sterile paper strips, samples were collected from healthy implants (I), healthy teeth (T) and peri‐implantitis affected implants (P). Proteome analysis was performed using liquid chromatography — tandem mass spectrometry (LC‐MS/MS) and data independent acquisition, allowing the identification and quantification of human and bacterial proteins as well as semi‐specific peptides.ResultsA total of 38 samples from 14 patients were included in the study; 2332 different human proteins were identified across all samples. No differentially expressed proteins between T and I were found. Comparing P to I, 59 proteins were found upregulated and 31 downregulated in P with significance. Upregulated proteins included proinflammatory proteins such as immunoglobulins, dysferlin, and S100P, as well as antimicrobial proteins, for example, myeloperoxidase or azurocidin. Gene ontology analysis further revealed higher activity of immunological pathways. Proteolytic patterns indicated the activity of inflammatory proteins such as cathepsin G. A total of 334 bacterial proteins were identified and quantified. Peri‐implantitis showed elevated proteolytic activity.ConclusionI and T share similarities in their proteome, while diseased implants deviate strongly from healthy conditions. The PICF proteome of peri‐implantitis affected sites exhibits an inflammatory fingerprint, dominated by neutrophil activity when compared with healthy implants.
Technical note: Multi‐receiver combination method for phase‐based electrical property tomography of the breast
Authors: Kim Jun‐Hyeong , Shin Jaewook , Jung Kyu‐Jin , Cui Chuanjiang , Kim Soo‐Yeon , Lee Jae‐Hun , Kim Dong‐Hyun 
Published: December 2022

AbstractBackgroundPhase‐based electrical property tomography (EPT) is a technique that allows conductivity reconstruction with only phase of the B1 field under the assumption that the magnitude of the B1 fields are homogeneous. The more this assumption is violated, the less accurate the reconstructed conductivity. Thus, a method that ensures homogeneity of field is important for breast image using multi‐receiver coil.PurposeTo develop a method for multi‐receiver combination for phase‐based EPT usable for breast EPT imaging in the clinic.MethodsTheory of the proposed method is presented. To validate the proposed method, the phantom and in‐vivo experiments were conducted. Conductivity images were reconstructed using the transceive phase of the combined image and results were compared with another combination method.ResultsThe proposed method's conductivity results were more stable than those of the previous method when was not homogeneous and when the homogeneous contrast region was small. The phantom and in‐vivo results indicate that the proposed method produces improved conductivity images than the previous method. The proposed combination method also increased the conductivity contrast between benign and cancerous tissues.ConclusionThe proposed method produced more stable multi‐receiver combination for phase‐based EPT of the breast in a clinical environment.