bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression
Authors: Grotehans Nils , McGarry Lynn , Nolte Hendrik , Xavier Vanessa , Kroker Moritz , Narbona‐Pérez Álvaro Jesús , Deshwal Soni , Giavalisco Patrick , Langer Thomas , MacVicar Thomas 
Published: July 2023

AbstractReplication of the mitochondrial genome and expression of the genes it encodes both depend on a sufficient supply of nucleotides to mitochondria. Accordingly, dysregulated nucleotide metabolism not only destabilises the mitochondrial genome, but also affects its transcription. Here, we report that a mitochondrial nucleoside diphosphate kinase, NME6, supplies mitochondria with pyrimidine ribonucleotides that are necessary for the transcription of mitochondrial genes. Loss of NME6 function leads to the depletion of mitochondrial transcripts, as well as destabilisation of the electron transport chain and impaired oxidative phosphorylation. These deficiencies are rescued by an exogenous supply of pyrimidine ribonucleosides. Moreover, NME6 is required for the maintenance of mitochondrial DNA when the access to cytosolic pyrimidine deoxyribonucleotides is limited. Our results therefore reveal an important role for ribonucleotide salvage in mitochondrial gene expression.
Consumer Law and Environmental Protection: Consumer Sales Directive 2019/771 Example
Authors: Selvestravičiūtė Agnė 
Published: July 2023

This paper reviews principal coherence of EU Consumer law and environmental protection as demonstrated through analysis of Consumer Sales Directive. After dichotomy between EU consumer and environmental protection, and EU primary law’s obligation to coordinate these areas is assessed, rules of directive which reflect (or conversely – neglect) environmental protection goal are analysed. It is later argued that directive basically ignores Union’s quest towards sustainability. Although singular rules from directive may indeed be changed hoping it would help to fight ecological problems, taking consumer law’s role in solving ecological challenges seriously means more than fine-tuning several provisions but changing consumer law fundaments’ instead.
Assessing and Improving WIC Enrollment in the Primary Care Setting: A Quality Initiative
Authors: Monroe Bryan S. , Rengifo Lina M. , Wingler Meagan R. , Auriemma Jeanna R. , Taxter Alysha J. , Ramirez Brenda , Albertini Laurie W. , Montez Kimberly G. 
Published: July 2023

BACKGROUND AND OBJECTIVES
The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) provides food and other resources to mitigate the harmful effects of food insecurity on child and maternal health. From a 2009 peak, nationwide WIC participation declined through 2020. Our objectives were to understand factors influencing WIC engagement and improve WIC enrollment through novel, primary care-based quality improvement interventions.

METHODS
Plan-do-study-act cycles were implemented at a majority Medicaid-insured pediatric primary care clinic. Universal WIC screening at &lt;5-year-old well-child visits was initiated, with counseling and referrals offered to nonparticipants. Clinic providers received WIC education. WIC screening, counseling reminders, and referrals were streamlined via the electronic health record. Families were surveyed on WIC participation barriers. Patient demographic data were analyzed for predictors of WIC participation.

RESULTS
Mean new WIC enrollments increased significantly (42%) compared with baseline, with sustained special cause variation after study interventions. Provider WIC knowledge improved significantly at study end (P &lt;.001). Rates of WIC screening, counseling, and referrals remained stable for &gt;1 year after study interventions. The most common family-reported barriers to WIC participation were “Access problems” and “WIC knowledge gap.” Factors associated with decreased WIC participation in multivariable analysis were increasing age (P &lt;.001), and non-Medicaid insurance status (P = .03).

CONCLUSIONS
We demonstrate feasible primary care-based screening, education, and referral interventions that appear to improve WIC enrollment. We identify knowledge gap and access problems as major potentially modifiable barriers to WIC participation. The expansion of similar low-cost interventions into other settings has the potential to benefit under-resourced children and families.
Nierówności w health literacy – aspekty przestrzenne i edukacyjne
Authors: Korporowicz-Żmichowska Violetta 
Published: July 2023

Health literacy (literacy) jest to zdolność jednostki do „odczytywania zdrowia” przez uzyskiwanie dostępu do informacji oraz efektywnego wykorzystywania jej w celu utrzymania dobrego stanu zdrowia. Przejawia się to przez: rozumienie treści przekazywanych w informacjach medycznych, umiejętności korzystania z usług medycznych, a następnie respektowanie zaleceń profesjonalistów. Występują tutaj jednak liczne nierówności. Nierówności te związane są zarówno z typem kształcenia (różnice między uczniami uczącymi się w różnych typach szkół), jak i przestrzenią, i to nie tylko między regionami, ale też wewnątrz regionów, czyli między młodzieżą mieszkającą w miastach i mieszkającą na wsiach.Celem artykułu jest wskazanie na nierówności dotyczące health literacy dorosłej, uczącej się młodzieży województwa mazowieckiego, biorąc pod uwagę typ kształcenia: licea ogólnokształcące, technika i szkoły branżowe i układ przestrzenny (miasto – wieś) oraz prezentacja sondażu diagnostycznego (badania) „Młodzież Mazowsza”. Tezą badania jest stwierdzenie, że nierówności w zachowaniach zdrowotnych zależne są od typu kształcenia i od zróżnicowań przestrzennych. Sondaż był realizowany wśród młodzieży uczącej się w szkołach ponadpodstawowych w roku szkolnym 2017/2018. Narzędziem badawczym jest tu skonstruowany na potrzeby badania autorski kwestionariusz ankiety do przeprowadzenia wywiadu audytoryjnego. Na podstawie sondażu z zakresu health literacy oceniano, w jaki sposób typ kształcenia wpływa na ocenę własnego zdrowia oraz na świadomość możliwości jego kształtowania przez własne zachowania, gdzie pod uwagę brano poszczególne wytypowane zachowania, a następnie zróżnicowania tych zachowań między miastem a wsią. W świetle badania „Młodzież Mazowsza” można zaobserwować wśród respondentów województwa mazowieckiego szczególnie ze szkół branżowych ogólną, stosunkowo niższą w stosunku do pozostałej badanej młodzieży ocenę własnego zdrowia i zachowań zdrowotnych. Natomiast brak jest istotnych zróżnicowań między miastem a wsią.
O DIREITO À SAÚDE E O CONCEITO DE JUSTIÇA DISTRIBUTIVA – ANÁLISE DOS CRITÉRIOS ESTABELECIDOS NO REsp 1.657.156 PELO SUPERIOR TRIBUNAL DE JUSTIÇA
Authors: Guizzo Antonio Rediver , Soalheiro Grade Maíra 
Published: July 2023

O direito à saúde e as diversas controvérsias dele decorrentes têm ocupado um amplo espaço nos debates jurídicos na atualidade. A inserção no texto constitucional da saúde como direito humano e fundamental e, por consequência, a responsabilidade pela garantia a todos os cidadãos do acesso universal e igualitário às ações e serviços para a promoção, proteção e recuperação da saúde constitui um enorme desafio para o Estado brasileiro. Neste contexto, o presente artigo, por meio da reflexão sobre o direito à saúde e o conceito de justiça distributiva na visão de autores como Aristóteles, John Rawls e Amartya Sen, possui o objetivo de analisar se o Superior Tribunal de Justiça, ao estabelecer a observância obrigatória de três requisitos cumulativos para o fornecimento de medicamentos não incorporados em atos normativos do SUS, por ocasião do julgamento do REsp 1.657.156, aproximou-se da garantia de equidade no direito à saúde no Brasil. Quanto à metodologia referente ao presente trabalho, utilizou-se o método dedutivo, com pesquisa bibliográfica e abordagem qualitativa. A análise realizada por meio do presente artigo permitiu concluir que ainda constitui um grande desafio para o sistema de saúde e para o Judiciário brasileiro a efetivação de um acesso justo e equitativo à saúde, pois a despeito da necessidade do estabelecimento de critérios objetivos para a uniformização das decisões judiciais, a utilização do requisito da incapacidade financeira do paciente para arcar com o custo do medicamento deixa de ponderar fatores relevantes para o estabelecimento da efetiva necessidade da prestação jurisdicional.
The Digital Practices of Portuguese Children (6-18) during Covid-19 Lockdown
Authors: Dias Patrícia , Brito Rita 
Published: July 2023

The Covid-19 pandemic was addressed, in most European countries, with a mandatory lockdown period, during which the use of digital technologies was intensified, for remote working, communication, entertainment, consumption and learning. Our research aims to map the digital practices of Portuguese children (6-18) during lockdown (between March 19th and May 2nd 2020), focusing on their experience of formal Education and on their wellbeing.
Our empirical work follows a mixed method, combining an online survey to a representative sample of 509 dyads of parents and children (10-18) and in-depth interviews to families with younger children (6-12).
Our findings confirm a significant intensification of the use of digital technologies by children, partly required by school, partly due to the lack of alternatives for entertainment and socialization. Most children find using digital technologies for long periods, due to remote schooling, tiresome and feel anxious due to recurrent news about Covid-19.
Underemployment and overemployment in Central Europe
Authors: Dvouletý Ondřej 
Published: July 2023

This research examines the working hours preferences of the employees in selected Central European countries, specifically in the Czech Republic, Hungary and Poland. Using the country-representative data from the 2017 edition of the European Union Labour Force Survey (EU LFS), the study investigates the discrepancies between respondents' desired working hours and those usually worked per week. A comparative econometric analysis of those individuals who work more than they wish (overemployed) and those who work less than they desire (underemployed) is conducted. Several interesting observations came out of the performed analysis. We document some significant variables shaping these two situations occurring in the Central European labour markets. The obtained findings document the heterogeneity concerning gender, education, migration background, experience and occupation.
Impact of Fandom Culture on Family Harmony from Islamic Perspective
Authors: Raihana Siti Nazla , Syarafuddin Muhsan 
Published: July 2023

The development of fandoms is very rapid; all artists have their fandoms. Almost everyone joins a fandom for leisure, and it is very accessible. These fandom activities certainly impact the fan's life and relationship with the family. This study explores fandom culture's impact on family harmony and Islamic views of fandom. Fandom is an activity that describes the closeness between fans and their idols based on cultural products. This study used a qualitative case study approach with a purposive sampling of thirty informants. The result shows that fandom has five negative impacts on family harmony, namely: (1) neglecting family members from their obligations; (2) causing addiction, jealousy, and wastefulness; (3) children disobeying parental orders; (4) parents having difficulty taking care of children; and (5) poor communication between family members. Furthermore, fandom activities contradict Islamic teachings for five reasons, namely: (1) music and singing; (2) lousy consumerism; (3) wasting time; (4) the wrong community; and (5) bad lifestyle. Family members should advise each other so that no member joins the fandom, thereby endangering the harmony of the family. Perkembangan fandom sangat pesat, semua artis memiliki fandom masing-masing. Hampir semua orang bergabung dengan fandom untuk mengisi waktu luang, dan itu sangat aksesibel. Kegiatan fandom ini tentunya punya dampak untuk kehidupan sang penggemar dan hubungannya dengan keluarga. Penelitian ini bertujuan mengeksplorasi dampak budaya fandom terhadap keharmonisan keluarga dan pandangan Islam terhadap fandom. Fandom merupakan aktivitas yang menggambarkan kedekatan antara penggemar dan idolanya yang didasari oleh produk budaya. Penelitian ini menggunakan pendekatan kualitatif bersifat studi kasus dengan pengambilan sampel secara purposive sampling dari tiga puluh informan. Penelitian ini menunjukkan hasil bahwa fandom memiliki lima dampak negatif terhadap keharmonisan keluarga yaitu: (1) melalaikan anggota keluarga dari kewajibannya; (2) menimbulkan kecanduan, iri hati, dan keborosan;(3) anak tidak mematuhi perintah orang tua; (4) orang tua kesulitan untuk mengurus anak-anak; (5) komunikasi yang tidak baik antar anggota keluarga. Selanjutnya, kegiatan fandom menyelisihi ajaran agama Islam dengan lima alasan yaitu: (1) musik dan nyanyian; (2) konsumerisme yang buruk; (3) membuang waktu; (4) komunitas yang buruk; (5) gaya hidup yang tidak baik. Hendaknya anggota keluarga saling menasehati satu sama lain agar tidak ada anggota yang bergabung dengan fandom, sehingga membahayakan keharmonisan keluarga tersebut.
THE ANALYSIS OF LANGUAGE STYLE USED IN MERRY RIANA’S YOUTUBE CHANNEL ON THE PLAYLIST ‘SPOKEN WORD’
Authors: Br Sitepu Ester Febrina , Zahara Ayuna , Cahyani Putri Ardhia Amalya , Rangkuti Rahmadsyah 
Published: July 2023

The aim of this study was to find out the types of language styles and identify the dominant style of language used by Merry Riana in her selected motivational speech videos as a motivator. The data of this study were taken from Merry Riana’s YouTube Channel and the researchers chose 3 motivational speech videos in the "SPOKEN WORD" playlist. In analyzing the data, the researchers used descriptive qualitative method. The researchers used the theory proposed by Martin Joss (1967) to identify the types of language styles. According to Martin Joss (1967), there are five language styles: frozen style, formal style, casual style, consultative style, and intimate style. The researchers found that in Merry Riana’s motivational speech used three language styles from five language styles proposed by Martin Joss. There were 64 formal styles, 42 casual styles, and 4 intimate styles from the 117 sentences uttered by the speaker in the selected video. The most dominant style of language found in this study was the formal style.
Geomechanical Rock Properties from Surface Drilling Telemetry
Authors: Olkhovikov Aleksei , Koroteev Dmitry , Antipova Ksenia 
Published: July 2023

Summary
We present a novel approach for real-time estimation of the mechanical properties of rock with drilling data. We demonstrate that surface drilling telemetry (also known as mud logging) can be used as an input for a trained machine learning (ML) algorithm to predict the properties of the rock being drilled at the moment. The study involves data from several real wells with horizontal completions. We use mud logging and logging while drilling (LWD) data from one part of the wells to train various ML models. The models are compared by various metrics using the five fold cross-validation technique. We also show the importance of proper feature selection for maximizing models’ performance in operation mode.
Case Report: a Severe Asthma Symptom With Biological Medication
Authors: Chang Sajjad Ali 
Published: July 2023

Abstract
Research from Sindh Pakistan showed that 15% of patients are in therapy phases, many based on data from the specialized literature. According to the Global Initiative for Asthma, around 9.8% of grownup females and 6.1% of the male population suffer from asthma. In this instance, a 31-year-old patient who has had bronchial asthma for more than ten years and who has never had occupational exposure to the condition is presenting with persistent dyspnea at rest, wheezing, and mechanical ventilation. This patient has also had multiple hospitalizations in the Pneumology Service for severe exacerbations. One of these exacerbations required hospitalization in the Anesthesia and Intensive Care Service, orotracheal intubation, and mechanical ventilation manifesting with chest tightness, wheezing, and persistent dyspnea when at rest and obstructive ventilatory dysfunction with a 37.57% decrease in maximum expiratory volume per second and 156% reversibility. No acute lesions on the X-ray pleuro-pulmonary: 13,550 leukocytes; 5566 eosinophils per milliliter; 4107%. Allergy caused by immunoglobulin E (IgE) confirmed, and IgE total of 513 IU/L, no sensitivities to skin prick testing, according to an allergy consultation and epithelial allergy, herbatum, and fumigatus specific IgE. Bronchoscopic techniques were used to rule out pulmonary aspergillosis, and mycological tests came back negative. Treatment with omalizumab 300 mg per month began, with no need for hospitalizations, exacerbations, or systemic corticosteroid therapy.
International Multilingual Students’ Perceptions of Learning English in a Multilingual Setting
Authors: AL-Roomy Muhammad A. 
Published: July 2023

Abstract
Students’ perceptions about learning in English influence the way they approach their learning either toward the target language itself or toward the learning in general. This paper aims to probe participants’ perceptions of learning a foreign language in the United States in multilingual settings. Using the snowball technique, seven participants were recruited for the purpose of the study. Later, focus group interviews were carried out to collect data and were analyzed using the NVivo software. The findings demonstrated that participants held different perceptions before and after studying in the US that positively or negatively affected their English learning. The most frequent themes were related to the high quality of learning in the US, which increased students’ motivation to study with native English teachers. Students’ prior learning experiences were another theme that emerged; these experiences were overcome when students adjusted their learning and looked for best learning practices. They took advantage of being in the US to practice their English in authentic situations. The least frequent themes were motivation and accent, which students believed were less important in their learning. After an analysis of these findings, this paper concludes with some pedagogical implications and recommendations for further research.
Optimal Highway Ramp Speed Control with Deep Reinforcement Learning
Authors: Shen Zhou (Eric) 
Published: July 2023

Abstract
Highway ramp speed control plays a critical role in optimizing traffic flow and improving transportation system efficiency. In this paper, we propose an optimal highway ramp speed control method using deep reinforcement learning. By leveraging the power of deep neural networks and reinforcement learning, our method, named DeepRampControl, learns to dynamically adjust vehicle speeds at ramps to minimize disruptions to the main traffic flow. We compare DeepRampControl with traditional rule-based approaches and other machine learning-based methods through comprehensive experiments in a simulated environment. The results demonstrate that DeepRampControl achieves higher traffic flow efficiency, lower average merging delay, and reduced energy consumption. These findings highlight the potential of deep reinforcement learning in optimizing highway ramp speed control and its ability to adapt to dynamic traffic conditions. The proposed method contributes to the development of intelligent and adaptive traffic control systems, paving the way for more efficient and sustainable transportation networks.
MEMBANGUN KARAKTER BERPIKIR KRITIS MAPEL GEOGRAFI MELALUI MEDIA PEMBELAJARAN BERBASIS LEARNING TO DO OLEH UNESCO
Authors: WAHYUDI ADIP 
Published: July 2023

Guru sebagai pendidik perlu merekayasa perancang pembelajaran dalam membangun karakter berpikir kritis yang berpusat pada siswa. Berdasarkan permasalahan ini perlu adanya perkembangan dalam media pembelajaran yang dapat mengaktifkan siswa melalui media pembelajaran seperti pemanfaatan penggunaan media pembelajaran Learning To Do .Pembelajaran Learning To Do dapat dilakukan dengan menggunakan strategi pembelajaran yang aktif, kreatif, efektif dan menyenangkan (PAKEM) melalui pembelajaran yang berbasis masalah, pembelajaran kooperatif, pembelajaran berbasis proyek dan lain-lain. Pembelajaran berbasis inquiry dan storytelling dapat meningkatkan kemampuan berpikir kritis siswa. Tulisan ini mengungkap (1) pentingnya pendidikan sebagai pembentuk karakter (2) pengembangan karakter berpikir kritis berbasis media pembelajaran Learning To Do oleh UNESCO dan (3) konsep dasar pendidikan Learning To Do . Penelitian ini menggunakan data jenis kepustakaan (library research) dari penelitian kualitatif diperoleh dengan menggunakan teknik pengumpulan data yaitu identifikasi wacana dari sumber sekunder berupa jurnal dan buku yang relevan. Hasil penelitian menunjukkan bahwa pilar “Learning To Do ” penting diaplikasikan dalam media pembelajaran untuk membangun karakter berpikir kritis.
Flood modelling for a real-time decision support system of the covered Lower Paillons River, Nice, France
Authors: Game Paguédame , Wang Mingyan , Audra Philippe , Gourbesville Philippe 
Published: July 2023

Abstract

Nice Metropolis in Alpes Maritimes, France is prone to flood. The city is crossed by the Lower Paillons River (LPR). Its discharge for a return period of 100 years is estimated at 794 m3/s. Part of the river is covered by 2 km. In addition, there are two retention storages in the river bed and a floodable road tunnel on the left bank. Due to the increase in urban development, flood management is challenging. An existing decision support system, Aquavar, uses DHI Mike tools to reproduce runoff for the Lower Var River in the same region. To extend this system to the LPR and reinforce flood management, a new modelling tool adapted to the characteristics of the LPR is needed. Consequently, this research utilizes the DHI MIKEPLUS tool to develop a 1D -2D coupled model for real-time flood management. The results demonstrate that flood events like those in 2017 and 2019 were correctly reproduced. The linear regression R2 is above 0.8 for all stations. It was also estimated that the covered river should stay clean to avoid widespread flooding in the urban area. Overall, the model is useful for simulating flow in real time and can help sustain urban development.
Research of Active Compounds from Allii Macrostemonis Bulbus and
Potential Targets against Non-Hodgkin’s Lymphoma Based on Network
Pharmacology
Authors: Qiu Xiuliang , Zhao QiuLing , Qiu Hongqiang , Cheng Yu , Liu WenBin , Yang Lin 
Published: July 2023

Background:
Non-Hodgkin’s Lymphoma (NHL) is a series of lymphoid malignancies
in some aggressive subtypes with unsatisfactory treatment effects. Allii Macrostemonis Bulbus
(Xie Bai) is a traditional Chinese medicine with anti-cancer activities, which may potentially suppress
aggressive NHL.

Objective:
This study tries to discover active components and targets of Xie Bai in treating NHL
by network pharmacology-based approaches.

Methods:
Compounds and related targets of Xie Bai were collected from the Traditional Chinese
Medicine Database and Analysis Platform. Target genes associated with NHL were searched by
GeneCards and DisGeNET, then the overlapped targets were further analyzed by STRING tool,
GO, and KEGG pathway enrichment analysis. Molecular docking was employed to verify the interaction
between compounds and targets.

Results:
11 bioactive compounds were successfully identified, with 30 targets that were screened
out for the treatment of NHL. Functional enrichment analysis suggested that Xie Bai exerted its
potential effects against NHL via pathways in cancer, such as PI3K/ AKT, p53, and MAPK signaling
pathways. Molecular docking results showed that 3 active compounds (quercetin, betasitosterol,
and naringenin) had good affinity with selected 6 targets (TP53, AKT1, CASP3,
CCND1, HPK1, and NLRP3).

Conclusion:
Identifying six potential genes could accurately be docked with Xie Bai and had
close interactions with NHL, which may provide insight into further research and new treatment
strategy.