bluuebunny/crossref_metadata_2025_split huggingface dataset:
Komunikacja w radiu finansowanym przez społeczność. Przypadek internetowej stacji Radio 357
Authors: Chmielewski Piotr 
Published: July 2023

Celem tekstu jest analiza modelu komunikacji z patronami Radia 357 – internetowej stacji radiowej finansowanej przez słuchaczy przy wykorzystaniu patronatu cyfrowego. Metodologia: dokonano jakościowej analizy treści znajdujących się na forum dla patronów rozgłośni. Na materiał empiryczny złożyło się 200 postów stacji, 21 081 komentarzy patronów oraz nagrania filmowe trwające łącznie 1050 minut. Analiza objęła okres od października 2020 r. do stycznia 2022 r. Wyniki i wnioski: przeprowadzona analiza wskazuje, że model komunikacji Radia 357 jest silnie uwarunkowany przez sposób finansowania rozgłośni. Stacja równolegle komunikuje się ze wszystkimi słuchaczami (za pośrednictwem strony internetowej oraz mediów społecznościowych) i moderuje odrębne fora dla najbardziej zaangażowanych patronów. Komunikacja wynika częściowo z indywidualnego modelu przyjętego przez rozgłośnię, częściowo zaś z ram i narzędzi narzuconych przez techniczne uwarunkowania platformy crowdfundingowej, na której prowadzona jest zbiórka. Wartość badawcza: analiza dostarcza wiedzy na temat charakterystyki oraz mocnych i słabych stron opisywanego modelu komunikacji. Co szczególnie ważne, zważywszy na ostatnie dekady dynamicznego rozwoju radiofonii, model ten istotnie różni się od dotychczasowego sposobu komunikowania tradycyjnych stacji radiowych.
Knowledge Broker Sebagai Mediasi: Merancang Perilaku Inovasi Dalam Mendukung Transformasi Digital Pada Ukm Di Sidoarjo
Authors: Larassaty Ayu Lucy 
Published: July 2023

Small and Medium Enterprises (SMEs) have an important role for the economy of a country in order to increase productivity, competition and be able to open up business opportunities and create job opportunities. The phenomenon that occurs in the UKM environment in Sidoarjo is that UKM actors only focus more on tangible assets so they pay less attention to intangible assets. The purpose of this study is to find out the role and implementation of knowledge brokers to design innovative behavior in supporting digital transformation for SMEs in Sidoarjo. The research method uses the Field Research approach using qualitative research types. The data collection technique uses triangulation which consists of documentation, interviews, observation and surveys as well as recording archives. The results of the study explain the implementation of knowledge brokers to design innovative behavior in supporting digital transformation in SMEs in Sidoarjo, which is still limited to Knowledge sharing where knowledge brokers are structured and designed as a bridge in providing information and consulting carried out by universities and organizational partners only in training activities and accompaniment. The role of knowledge brokers is very important in implementing strategies in utilizing company-owned resources to encourage digital transformation in SMEs, which can utilize digital technology to mediate interactions between stakeholders and SMEs who need capital in their businesses. expand business with investors who will invest to get a return on investment. This interaction increases digital literacy for SMEs and enhances the process of sharing and disseminating knowledge between organizations.
Synthesis and Characterization of Eco-friendly, Biodegradable Plasticized Starch Nanocomposite using Graphene Oxide Nano-filler for Energy Storage Applications
Authors: Mollik S Islam , Mahmud E , Mina M F , Islam M R 
Published: July 2023

In this study, environment-friendly, biodegradable nanocomposite has been fabricated using plasticized starch (PS) polymer and graphene oxide (GO) nanofiller. Biodegradable PS has been extracted from potatoes and a solution casting technique was used to synthesize PS/GO nanocomposite. The structural and surface morphological properties of the nanocomposite have been studied via FTIR and FESEM which demonstrate increased degree of interaction between the PS matrix and the GO nanofiller. The thermal properties of the nanocomposite showed that incorporation of GO improves the thermal stability of the nanocomposites. To study the energy storage capabilities of the PS/GO nanocomposites the electrochemical properties of the nanocomposites were as studied through cyclic voltammetry (CV), and galvanostatic charge-discharge (GCD) methods. The PS/GO nanocomposite showed improved capacitive performance with a specific capacitance of 112 F/g compared to that of pure starch (2.20 F/g) at a current density 0.1 mA/cm2. To study the effect of GO on the electrochemical properties of the nanocomposites, electrochemical impedance spectroscopy was performed and the corresponding graphs were simulated using simulation software. The incorporation of GO reduces the charge transfer resistance and thereby improve the capacitive performance. The improved electrochemical performance of the PS/GO nanocomposite can be further attributed to the large surface areas provided by the GO sheets allowing faster transport of electrolyte ions into the electrode. The result indicates that the PS/GO and nanocomposites may offer a promising route for the synthesis of bio-friendly and flexible energy storage devices.
J. of Sci. and Tech. Res. 4(1): 145-154, 2022
NOVO ENSINO MÉDIO: ANÁLISE E PROJEÇÕES
Authors: Beloti Adriana , Grzeca Francini Carla , Bohrer Marcos 
Published: July 2023

Esta entrevista com Daniel Cara, professor e pesquisador na área de educação, com o objtivo de debater o Novo Ensino Médio - NEM -, imposto pela reforma educacional materializada na Base Nacional Comum Curricular – BNCC -, de 2018.
Magnesium production by molten salt electrolysis with liquid tin cathode and multiple effect distillation
Authors: Telgerafchi Armaghan Ehsani , Rutherford Madison , Espinosa Gabriel , McArthur Daniel , Masse Nicholas , Perrin Benjamin , Tang Zujian , Powell Adam C. 
Published: July 2023

Low-cost clean primary production of magnesium metal is important for its use in many applications, from light-weight structural components to energy technologies. This work describes new experiments and cost and emissions analysis for a magnesium metal production process. The process combines molten salt electrolysis of MgO using MgF₂-CaF₂ electrolyte and a reactive liquid tin cathode, with gravity-driven multiple effect thermal system (G-METS) distillation to separate out the magnesium product, and re-use of the tin. Electrolysis experiments with carbon anodes showed current yield above 90%, while a yttria-stabilized zirconia solid oxide membrane (SOM) anode experiment showed 84% current yield. G-METS distillation is an important component of the envisioned process. It can potentially lower costs and energy use considerably compared with conventional magnesium distillation. Techno-economic analysis including detailed mass and energy balances shows that this electrolyte composition could lower costs by utilizing CaO, which is the primary impurity in MgO, as the Hall-Héroult process uses the sodium impurity in alumina. Analysis options include: raw material types (magnesite rock vs. brine or seawater), drying and calcining using electricity vs. natural gas, and carbon vs. SOM anode type. Using SOM inert anodes results in a cost premium around 10%–15%, mostly due to higher electrical energy usage resulting from membrane resistance, and reduces GHG emissions by approximately 1 kg CO₂/kg Mg product. Capital and operating cost estimates, and cradle to gate greenhouse gas (GHG) emissions analysis under several raw material and process technology scenarios, show comparable costs and emissions to those of aluminum production.
Hypoxia-associated genes predicting future risk of myocardial infarction: a GEO database-based study
Authors: Li Shaohua , Zhang Junwen , Ni Jingwei , Cao Jiumei 
Published: July 2023

BackgroundPatients with unstable angina (UA) are prone to myocardial infarction (MI) after an attack, yet the altered molecular expression profile therein remains unclear. The current work aims to identify the characteristic hypoxia-related genes associated with UA/MI and to develop a predictive model of hypoxia-related genes for the progression of UA to MI.Methods and resultsGene expression profiles were obtained from the GEO database. Then, differential expression analysis and the WGCNA method were performed to select characteristic genes related to hypoxia. Subsequently, all 10 hypoxia-related genes were screened using the Lasso regression model and a classification model was established. The area under the ROC curve of 1 shows its excellent classification performance and is confirmed on the validation set. In parallel, we construct a nomogram based on these genes, showing the risk of MI in patients with UA. Patients with UA and MI had their immunological status determined using CIBERSORT. These 10 genes were primarily linked to B cells and some inflammatory cells, according to correlation analysis.ConclusionOverall, GWAS identified that the CSTF2F UA/MI risk gene promotes atherosclerosis, which provides the basis for the design of innovative cardiovascular drugs by targeting CSTF2F.
Cardiac “hypertrophy” phenotyping: differentiating aetiologies with increased left ventricular wall thickness on echocardiography
Authors: Ferkh Aaisha , Tjahjadi Catherina , Stefani Luke , Geenty Paul , Byth Karen , De Silva Kasun , Boyd Anita C. , Richards David , Mollee Peter , Korczyk Dariusz , Taylor Mark S. , Kwok Fiona , Kizana Eddy , Ng Arnold C. T. , Thomas Liza 
Published: July 2023

AimsDifferentiating phenotypes of cardiac “hypertrophy” characterised by increased wall thickness on echocardiography is essential for management and prognostication. Transthoracic echocardiography is the most commonly used screening test for this purpose. We sought to identify echocardiographic markers that distinguish infiltrative and storage disorders that present with increased left ventricular (LV) wall thickness, namely, cardiac amyloidosis (CA) and Anderson–Fabry disease (AFD), from hypertensive heart disease (HHT).MethodsPatients were retrospectively recruited from Westmead Hospital, Sydney, and Princess Alexandra Hospital, Brisbane. LV structural, systolic, and diastolic function parameters, as well as global (LVGLS) and segmental longitudinal strains, were assessed. Previously reported echocardiographic parameters including relative apical sparing ratio (RAS), LV ejection fraction-to-strain ratio (EFSR), mass-to-strain ratio (MSR) and amyloidosis index (AMYLI) score (relative wall thickness × E/e′) were evaluated.ResultsA total of 209 patients {120 CA [58 transthyretin amyloidosis (ATTR) and 62 light-chain (AL) amyloidosis], 31 AFD and 58 HHT patients; mean age 64.1 ± 13.7 years, 75% male} comprised the study cohort. Echocardiographic measurements differed across the three groups, The LV mass index was higher in both CA {median 126.6 [interquartile range (IQR) 106.4–157.9 g/m2]} and AFD [median 134 (IQR 108.8–152.2 g/m2)] vs. HHT [median 92.7 (IQR 79.6–102.3 g/m2), p &lt; 0.05]. LVGLS was lowest in CA [median 12.29 (IQR 10.33–15.56%)] followed by AFD [median 16.92 (IQR 14.14–18.78%)] then HHT [median 18.56 (IQR 17.51–19.97%), p &lt; 0.05]. Diastolic function measurements including average e′ and E/e′ were most impaired in CA and least impaired in AFD. Indexed left atrial volume was highest in CA. EFSR and MSR differentiated secondary (CA + AFD) from HHT [receiver operating curve–area under the curve (ROC-AUC) of 0.80 and 0.91, respectively]. RAS and AMYLI score differentiated CA from AFD (ROC-AUC of 0.79 and 0.80, respectively). A linear discriminant analysis with stepwise variable selection using linear combinations of LV mass index, average e′, LVGLS and basal strain correctly classified 79% of all cases.ConclusionSimple echocardiographic parameters differentiate between different “hypertrophic” cardiac phenotypes. These have potential utility as a screening tool to guide further confirmatory testing.
Left atrial enlargement and high uric acid level are risk factors for left atrial thrombus or dense spontaneous echo contrast in atrial fibrillation patients with low to moderate embolic risk assessed by CHA2DS2-VASC score
Authors: Tan Chao-Di , Liu Juan-Zhang , Zheng Yu-Ping , Li Zong-jian , Zhou Shu-Xian 
Published: July 2023

AimsTo investigate the correlation and predictive value of left atrial diameter and blood uric acid levels with the occurrence of left atrial thrombus or dense spontaneous echo contrast in atrial fibrillation patients with low to moderate CHA2DS2-VASc scores.Methods and resultsA total of 849 inpatients diagnosed with atrial fibrillation who had low to moderate CHA2DS2-VASc scores and complete transesophageal echocardiography were included in this study. Among them, 66 patients had left atrial thrombus or dense spontaneous echo contrast. When different models were used to correct other known risk factors, acid levels and abnormal left atrial diameter were identified as additional risk factors for left atrial thrombus or dense spontaneous echo contrast. The incidence of left atrial thrombus or dense spontaneous echo contrast was higher in patients with abnormal serum uric acid levels than in the control group (12.4% vs. 5.6%, p &lt; 0.05), and this difference persisted after correcting the baseline data with propensity score matching (10.6% vs. 4.1%, p &lt; 0.05). Abnormal left atrial diameter was another risk factor suggested by regression analysis, with an increased incidence of left atrial thrombus or dense spontaneous echo contrast in the abnormal left atrial diameter group compared to the control group, both before (18.0% vs. 3.5%, p &lt; 0.05) and after (15.5% vs. 5.2%, p &lt; 0.05) propensity score matching. The best predictive value was obtained by adding both abnormal serum uric acid levels and abnormal left atrial diameter.ConclusionLeft atrial enlargement and high uric acid levels increase the risk of left atrial thrombus or dense spontaneous echo contrast in atrial fibrillation patients with low to moderate CHA2DS2-VASc scores.
N6-methyladenosine with immune infiltration and PD-L1 in hepatocellular carcinoma: novel perspective to personalized diagnosis and treatment
Authors: Shi Yanlong , Wang Yizhu , Zhang Wenning , Niu Kaiyi , Mao Xinyu , Feng Kun , Zhang Yewei 
Published: July 2023

BackgroundIncreasing evidence elucidated N6-methyladenosine (m6A) dysregulation participated in regulating RNA maturation, stability, and translation. This study aimed to demystify the crosstalk between m6A regulators and the immune microenvironment, providing a potential therapeutic target for patients with hepatocellular carcinoma (HCC).MethodsTotals of 371 HCC and 50 normal patients were included in this study. GSE121248 and GSE40367 datasets were used to validate the expression of HNRNPC. The R package “ConsensusClusterPlus” was performed to screen consensus clustering types based on the expression of m6A regulators in HCC. The R package “pheatmap”, “immunedeconv”, “survival”, “survminer” and “RMS” were applied to investigate the expression, immunity, overall survival, and clinical application in different clusters and expression groups. Comprehensive analysis of HNRNPC in pan-cancer was conducted by TIMER2 database. Besides, HNRNPC mRNA and protein expression were verified by qRT-PCR and immunohistochemistry analysis.ResultsMost of m6A regulators were over-expressed excerpt for ZC3H13 in HCC. Three independent clusters were screened based on m6A regulators expression, and the cluster 2 had a favorable prognosis in HCC. Then, the cluster 2 was positively expression in macrophage, hematopoietic stem cell, endothelial cell, and stroma score, while negatively in T cell CD4+ memory and mast cell. We identified HNRNPC was an independent prognostic factor in HCC, and nomogram performed superior application value for clinical decision making. Moreover, PD-L1 was significantly up-regulated in HCC tissues, cluster 1, and cluster 3, and we found PD-L1 expression was positively correlated with HNRNPC. Patients with HCC in high-expression groups was associated with tumor-promoting cells. Besides, HNRNPC was correlated with prognosis, TMB, and immune checkpoints in cancers. Particularly, the experiments confirmed that HNRNPC was positively expression in HCC cells and tissues.ConclusionThe m6A regulators play irreplaceable roles in prognosis and immune infiltration in HCC, and the relationship of HNRNPC and PD-L1 possesses a promising direction for therapeutic targets of immunotherapy response. Exploration of m6A regulators pattern could be build the prognostic stratification of individual patients and move toward to personalized treatment.
The Russian registry of primary hyperparathyroidism, latest update
Authors: Mokrysheva Natalia G. , Eremkina Anna K. , Elfimova Alina R. , Kovaleva Elena V. , Miliutina Anastasiia P. , Bibik Ekaterina E. , Gorbacheva Anna M. , Dobreva Ekaterina A. , Maganeva Irina S. , Krupinova Julia A. , Salimkhanov Rustam H. , Aboishava Lizaveta A. , Karaseva Elena V. , Melnichenko Galina A. , Dedov Ivan I. 
Published: July 2023

IntroductionUntil recently no major epidemiological research of primary hyperparathyroidism (PHPT) has been conducted in the Russian Federation, this led to the creation of the Russian online registry. The objective of this study is to estimate the clinical and biochemical profile, classical and non-classical complications, surgical intervention and medical therapy of the patients with different forms of PHPT in the Russian Federation.Materials and methodsThe cross-sectional, observational, continuous study was conducted at the Endocrinology Research Centre (Moscow). The present study explored retrospective data from 6003 patients submitted to the Registry between 12.12.2016 and 25.10.2022 from 81 regions of the Russian Federation (http://pgpt.clin-reg.ru/).ResultsThe median age was 59 [60; 66] years with a female:male ratio of 11.7:1. Symptomatic PHPT was observed in 74.3% while asymptomatic form - only in 25.7% of cases. Bone pathology was the predominant clinical manifestation in 62.5% of cases (n=2293), mostly in combination with visceral complications 45.7% (n=1676). The majority of patients (63.3%) had combined visceral disorders including kidney damage in 51.8% and gastroduodenal erosions/ulcers in 32.3% of patients. Symptomatic patients were older (60 [53; 67] vs. 54 [45; 62] years, p&lt;0.001) and had more severe biochemical alterations of calcium-phosphorus metabolism. Cardiovascular disease (СVD) was recorded in 48% of patients, among them the most frequent was arterial hypertension (up to 93.9%). A genetic test was conducted in 183 cases (suspicious for hereditary PHPT) revealing the mutations in MEN1, CDC73, RET genes in 107, 6 and 2 cases, respectively. Surgery was performed in 53.4% of patients with remission achievement in 87%, the relapse/persistence were recorded in 13% of cases. Histological examination revealed carcinoma in 4%, atypical adenoma in 2%, adenoma in 84% and hyperplasia in 11% of cases. Drug therapy was prescribed in 54.0% of cases, most often cholecalciferol.ConclusionThe detection rate of PHPT has increased in the Russian Federation in recent years. This increase is associated with the start of online registration. However, the majority of patients remain symptomatic with significant alterations of phosphorus-calcium metabolism that indicates delayed diagnosis and requires further modifications of medical care.
Effect of sodium-glucose transporter 2 inhibitors on sarcopenia in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
Authors: Zhang Sha , Qi Zhan , Wang Yidong , Song Danfei , Zhu Deqiu 
Published: July 2023

ObjectiveSarcopenia has been recognized as the third category of disabling complications in patients with type 2 diabetes mellitus(T2DM), in addition to micro- and macrovascular complications. Sodium-glucose co-transporter 2 (SGLT2) inhibitors are innovative glucose-lowering treatments that have been shown to reduce body weight and enhance cardiovascular and renal outcomes. However, there is vigilance that SGLT2 inhibitors should be taken cautiously because they target skeletal muscle and may raise the risk of sarcopenia. Herein, we conducted a meta-analysis of randomized controlled trials to evaluate the effects of SGLT2 inhibitors on sarcopenia in patients with T2DM.MethodRelevant studies were obtained from PubMed, Embase, Medicine, Cochrane, and Web of Science databases to determine eligible studies until February 2023, without any language restrictions. A random effects model was utilized irrespective of heterogeneity, and the I2 statistic was used to evaluate study heterogeneity. The differences in results were measured using the weighted average difference (WMD) of the continuous data, along with a 95% confidence interval (CI).ResultsA total of 25 randomized controlled trials with 2,286 participants were included. SGLT2 inhibitors significantly reduced weight-related changes and fat-related changes, including body weight(BW) (WMD= -2.74, 95% CI: -3.26 to -2.23, P&lt;0.01), body mass index(BMI) (WMD= -0.72, 95% CI: -0.95 to -0.49, P&lt;0.01), waist circumference(WC) (WMD= -1.60, 95% CI: -2.99 to -0.22, P=0.02), fat mass(FM)(WMD= -1.49, 95% CI: -2.18 to -0.80, P&lt;0.01), percentage body fat(PBF) (WMD= -1.28, 95% CI: -1.83 to -0.74, P&lt;0.01), visceral fat area(VFA)(WMD= -19.52, 95% CI: -25.90 to -13.14, P&lt;0.01), subcutaneous fat area(SFA)(WMD= -19.11, 95% CI: -31.18 to -7.03, P=0.002), In terms of muscle-related changes, lean mass(LM)(WMD= -0.80, 95% CI: -1.43 to -0.16, P=0.01), and skeletal muscle mass(SMM) (WMD= -0.38, 95% CI: -0.65 to -0.10, P=0.007), skeletal muscle index(SMI) (WMD= -0.12, 95% CI: -0.22 to -0.02, P=0.02)were also significantly reduced. In addition, body water likewise decreased significantly (WMD=-0.96, 95% CI: -1.68 to -0.23, P=0.009).ConclusionsAs one of the most widely used hypoglycemic, SGLT2 inhibitors have beneficial effects on FM and BW weight loss in T2DM, such as BW, BMI, WC, FM, PBF, VFA, and SFA. However, the negative influence on muscle mass paralleled the reduction in FM and BW, and the consequent increased risk of sarcopenia warrants high attention, especially as patients are already predisposed to physical frailty.Clinical Trial Registrationhttps://www.crd.york.ac.uk/prospero/#myprospero, identifier PROSPERO (No.CRD 42023396278).
Exploring the mechanical, tribological, and morphological characteristics of areca fiber epoxy composites reinforced with various fillers for multifaceted applications
Authors: Miniappan P. K. , Marimuthu S. , Dharani Kumar S. , Sharma Shubham , Kumar Abhinav , Salah Bashir , Ullah Syed Sajid 
Published: July 2023

This investigation is primarily concerned with the effect of fly ash, basalt powder, and tungsten carbide (WC) on the mechanical, microstructural, and tribological behaviour of areca fiber-reinforced composites. The fillers (5–10 wt. %) were included with the areca fiber epoxy reinforced composites. In comparison to areca fiber composites without fillers, the inclusion of fly ash, basalt powder, and WC increased the tensile strength by 33–48.2 MPa. The tensile strength of an A2 composite containing areca fiber (20 wt. %), epoxy (70 wt. %) and basalt powder (10 wt. %) was measured to be 48.2 MPa. Similarly, filler incorporation enhanced flexural, impact, and Shore D hardness properties by up to 21.25%, 13.18%, and 15.66%, respectively. Furthermore, the hybridization of fillers enhanced the mechanical properties and abrasion resistance of areca fiber reinforced composites. The inclusion of filler increases the load-carrying capability and adhesion, as determined by SEM. The river-like pattern demonstrates that ductile failure was dominated in the A5 [areca fiber (20 wt. %), epoxy (70 wt. %), fly ash (5 wt. %) and basalt powder (5 wt. %)] composites. A4 [areca fiber (20 wt. %), epoxy (70 wt. %), fly ash (5 wt. %) and tungsten carbide (5 wt. %)] composite has a lower wear resistance than all other composites. The hybrid filler-reinforced composite exhibits increased wear resistance as a result of the absence of wear detritus and textured surfaces.