bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is strength training an effective physiotherapy-related strategy for injury prevention and performance enhancement in team sports? A scoping review of high-quality randomized controlled trials
Authors: Weerasinghe Kalani , Jayawardena Ranil , Hills Andrew P 
Published: January 2025

Abstract

Background
Muscular strength that can be improved through maximal, explosive, and reactive training, reduces injury risk and enhances sport-specific performance in athletes. In team sports, increased strength boosts physical and neuromuscular function, delays fatigue, speeds recovery and optimizes technical execution and decision-making during competition. Therefore, this scoping review aims to explore existing intervention studies to understand the role of strength training (ST) as an effective strategy for preventing injuries and enhancing performance in team sports.
Methods
A comprehensive search was conducted in five databases (SciVerse Scopus, PubMed, Web of Science, SPORTDiscus, and CINAHL) from 2015 to 2024. Keywords related to strength training, injuries, and team sports were used in the search. We included randomized controlled trials (RCTs) assessing the effectiveness of ST in preventing injuries and enhancing performance in team sports. The methodological quality of the included studies was assessed using the Physiotherapy Evidence Database scale.
Results
This review included 15 RCTs involving team sports: soccer (n = 9), volleyball (n = 3), and one each for football, handball, and rugby. Participants had a mean age range of 12.7 to 25.8 years, with sample sizes varying from 20 to 652 athletes. Four studies demonstrated dual benefits, highlighting the ability of ST to simultaneously enhance biomechanical alignment, address muscle imbalances, and optimize both injury prevention and performance outcomes. Three RCTs focused solely on strengthening interventions for injuries reported that ST effectively reduced the incidence of sports injuries, including hamstring strains (n = 2), groin injuries (n = 1), and overall injuries (n = 4). Performance metrics such as sprint speed, jump height, muscle strength, and endurance were significantly improved with ST in eight studies.
Conclusions
ST can be considered an effective physiotherapy-related strategy for injury prevention and performance enhancement in team sports across different age groups and genders, as suggested by high-quality RCTs.
Gut microbiota in young adults with high-functioning autism spectrum disorder and its performance as diagnostic biomarkers
Authors: Wong Sunny H , Ying Jiangbo , Xu Xinran , Zhou Ruwen , Chung Arthur C K , Ng Siu Kin , Fan Xiuyi , Subramaniam Mythily 
Published: January 2025

Abstract

Although autism spectrum disorder (ASD) starts in the early developmental period, symptoms may not become fully apparent until adulthood in patients with high-functioning ASD. Diagnosing ASD in adults presents unique challenges and there are currently no specific biomarkers for this condition. Most existing studies on gut microbiota in ASD are conducted in children; however, the composition of the gut microbiota in children differs significantly from that of adults. This study aimed to study young adults with high-functioning ASD on their gut microbiota. Using metagenomic sequencing, we evaluated the gut microbiota in 45 adults with high-functioning ASD and 45 matched healthy controls. Adjusting for sociodemographic information, dietary habits, and clinical data, we observed a distinct microbiota profile between adults with ASD and controls, with their autistic symptom severity strongly correlating to microbial diversity (correlation coefficient = -0.351, p-value <0.001). Despite a similar dietary pattern, the ASD group exhibited more gastrointestinal symptoms than the healthy controls. An internally validated machine-learning predictive model that combines the Autism Spectrum Quotient questionnaire score and microbial features could achieve an area under the receiver operating characteristic curve (AUC) of 0.955 in diagnosing ASD in adults. This study evaluates the gut microbiota in adult ASD and highlights its potential as a non-invasive biomarker to enhance diagnosis of ASD in this population group.
Analyzing Their Contribution to Water Demand, Quality, and Groundwater Sustainability of Private Water Wells in Addis Ababa, Ethiopia
Authors: Tura Tulu Tolla , Demeku Sisay 
Published: January 2025

Abstract

This study examines the role of private water wells in meeting the water demand, quality, and sustainability of groundwater resources in Addis Ababa, Ethiopia. As the city faces rapid urbanization and a rising population, private wells have emerged as a crucial supplementary water source, particularly in areas where public water supply is inadequate. However, challenges such as insufficient regulation, groundwater over-extraction, and contamination pose significant risks to the long-term viability of these wells. Data were gathered from 449 private wells, with a detailed water quality analysis conducted on 21 of them, focusing on parameters like turbidity, pH, nitrate, and fluoride levels. The findings indicate considerable variability in water quality; some wells exceeded safe limits for turbidity and nitrates, while others met acceptable standards for key indicators. Furthermore, groundwater extraction from private wells addresses only a small portion of the city's overall water demand. Compounding issues such as well interference, inefficient water usage, and declining water tables further complicate the situation. The study underscores the urgent need for enhanced regulation, integrated groundwater management, and active community participation to promote sustainable groundwater use. It also recommends strategies for improved well placement, ongoing water quality monitoring, and necessary infrastructural investments to alleviate the adverse effects associated with private well usage. This research offers important insights into urban water management dynamics and highlights the significance of private wells in supporting water supply in rapidly developing cities like Addis Ababa.
Establishing a Periodic SM Profile Model Based on Fourier Analysis using Hydrologic Soil Groups
Authors: Zhu Jinlong , Wang Shengyi , Li Qingliang 
Published: January 2025

Abstract

Accurately predicting global soil moisture (SM) is crucial for sustainable agriculture and water resource management. Recognizing the challenges posed by the heterogeneity of SM's spatiotemporal variability, this study proposes a novel approach that leverages Fourier analysis to decompose the periodic fluctuations in SM, revealing underlying trends and cycles. This approach is integrated with Long Short Term Memory (LSTM) networks to enhance the accuracy of global SM prediction. Fourier analysis transforms time series data of SM into frequencies and amplitudes, capturing its intrinsic periodic characteristics. This transformation reveals both variable and invariant features representing changes within and between periods. By fusing these periodic features within the cycle. By integrating these periodic features with sequence data and leveraging the memory and sequence learning capabilities of LSTM neural networks, the accuracy and reliability of global SM prediction can be enhanced. Our experiments on the LandBench1.0 dataset demonstrate that the proposed model reduces the root mean square error by 0.4% to 1.1% compared to the state-of-the-art methods. This study underscores that the LSTM with periodic features of SM can adapt to the inherent complex spatial-temporal patterns in SM dynamics, especially in scenarios characterized by rapid environmental changes and subtle temporal dynamics.
Potential regulatory modules to integrate microgravity signals into flowering pathways in Arabidopsis thaliana grown in space
Authors: Xie Junyan , Zhu Jiachen , Wang Lihua , Jiao Yuwei , Dou Yanhui , Zhao Zhongtian , Luo Boyu , Ha Meifan , Zheng Huiqiong 
Published: January 2025

Abstract

Our previous studies suggested that FLOWERING LOCUS (FT) can integrate microgravity signals into the photoperiodic flowering pathway in Arabidopsis. However, the exact mechanisms remain unclear. In this study, we carried out transcriptomic analysis of wild-type (WT), gigantea (gi) mutant, CONSTANS overexpressing plants (35S:CO), and transgenic plants expressing FT with the green fluorescent protein gene controlled by a heat shock-inducible promoter (pHSP:GFP;pHSP:FT, FG) grown on the Chinese space station in comparison with their ground controls. The findings revealed that transcriptional microgravity response signature was not only conserved primarily across the GI-CO-FT module disruption genotypes and WT, but also displayed GI-CO-FT module specific associated responses. Transcription factors belong to ERF, bZIP, bHLH, and BES1 families were significantly overrepresented to the GCC- and CACGTG-elements across GI-CO-FT specific microgravity responsive genes, suggesting the possible role of microgravity in regulating flowering time in space through integration pathways.
A Case of Postoperative Tension Hydrocephalus in the Wound Cavity Following High-Grade Glioma
Authors: Wei Qianfeng , Xiong Bangfa , Chen Yuwen , Liu Qian , Chai Erqing 
Published: January 2025

Abstract

Objective: To investigate the causes and treatment methods of postoperative tension hydrocephalus in high-grade gliomas.
Methods:A retrospective analysis was conducted on the clinical data of one patient with high-grade glioma who developed tension hydrocephalus in the tumor cavity postoperatively.
Results: The main causes of tension hydrocephalus in the tumor cavity of this patient were the formation of a unidirectional valve-like structure and the presence of "foreign bodies" within the cavity that created a high osmotic pressure, leading to a much slower absorption rate of cerebrospinal fluid (CSF) in the tumor cavity compared to the inflow rate, resulting in tension hydrocephalus. The patient exhibited facial palsy and limb weakness five days postoperatively, and emergency surgery was performed to relieve the valve-like structure and remove the foreign bodies within the cavity, releasing CSF to reduce the pressure in the tumor cavity, with good recovery postoperatively.
Discussion: High-grade glioma surgery should aim to minimize the formation of "valve" structures and the retention of foreign bodies and residual tissues within the tumor cavity.
Were there long-term health effects of exposure to parental migration on adult children? Evidence from rural China
Authors: Feng Qundi , Meng Fancun 
Published: January 2025

Abstract

Little is known about the role of parental rural-to-urban migration during childhood in shaping individuals’ health conditions. Using data from the China Health and Nutrition Survey, this study explores the long-term effect of parental migration during childhood on adult health outcomes. The extended regression model is employed to address the potential endogeneity of parental migration with an instrument variable. The results indicate that exposure to parental migration in childhood has a significant negative impact on adult height. Robustness checks using Body Mass Index and self-rated health status validate our findings. Mechanism analysis shows that parental migration significantly reduces left-behind children’s dietary quality in terms of food consumption patterns and dietary diversity. Given the insufficient protections related to left-behind children, there is a need for preventive intervention to mitigate the health disparity in the long term caused by parental migration.
JEL classification
I15, J13, O12
SLC6A6 alleviates cellular senescence in glioblastoma via the CSK/AKT/FoxO1 signaling
Authors: Li Wei , Xia Xianyou , Wang Ting , Zheng Yu , Liu Yunzhi , Lin Enqi , Liao Yuhang , Wu Guojia , Chen Runzhe , Zhuang Hao , Wang Dong , Wang Bo 
Published: January 2025

Abstract

・Background: Malignant glioblastoma exhibits cellular senescence characterized by changing tumor microenvironment. Solute carrier family 6 member 6 (SLC6A6), a multichannel transmembrane protein, plays a crucial role in regulating cell proliferation, apoptosis, differentiation and cellular microenvironment. However, the molecular mechanism of SLC6A6 in the cellular senescence of glioblastoma remains unknown. Our study aimed to elucidate the regulatory role and molecular mechanisms of SLC6A6 in the proliferation and senescence of glioblastoma cells.
・Methods: Expression of SLC6A6 was examined in tumor samples from 50 patients with glioblastoma, and associations between SLC6A6 expression and survival outcome were evaluated using Kaplan–Meier survival and Cox regression analyses. To investigate the mechanism of SLC6A6, we used short hairpin RNA (shRNA) and overexpression vector to construct SLC6A6-knockdown and -overexpression glioblastoma cells, respectively. The role of SLC6A6 in glioblastoma was confirmed in vitro and in an orthotopic glioblastoma mouse model.
・Results: Patients with high expression of SLC6A6 had a worse prognosis. Downregulation of SLC6A6 protein inhibited malignant phenotypes of glioblastoma cells in vitro. In addition, SLC6A6 affected tumor senescence by directly binding to CSK with its N-terminal cytoplasmic domain, thereby enhancing AKT phosphorylation. Furthermore, SLC6A6 knockdown inhibited tumor growth and shortened survival in the glioblastoma xenograft mouse model.
・Conclusion: SLC6A6 can promote malignant progression and inhibit cellular senescence of glioblastoma cells by affecting the CSK/AKT/FoxO1 signaling pathway. SLC6A6 might be a valuable biomarker in the treatment of glioblastoma.
Effects of Catastrophic Healthcare Expenditure on Household Labor Supply in Malawi
Authors: Ndipo Wellem , Munthali Spy 
Published: January 2025

Abstract

Background The dynamics of labor supply and demand are examined via microeconomic theory at the individual firm and worker levels. A number of factors influence the amount and quality of the labor supply; one such determinant is health status. Research has viewed the connection between household labor supply and health as a two-way causal relationship, with health serving as the deciding factor that influences decisions made in the labor market. The labor supply of a particular household or individual is seen to be affected by a number of factors, with the health status of an individual or a family member being one of them. Households or individuals are forced to either increase or reduce the number of hours they offer to work with respect to the amount of income they spend in trying to cover health care expenses. A household is seen to fall into a health care spending catastrophe if its aggregate health expenditure exceedsa given threshold; thus, in this case, the study uses the 10% and 40% thresholds.
Objective This study analyzed the effect of catastrophic health care expenditures on the household labor supply.
Methods This study used the Fifth Integrated Household Survey, which consists of 11,434 respondents. An instrumental variable approach with a binary outcome variable was employed to estimate the causal effect of catastrophic health expenditures on the household labor supply in hours.
Results The results from instrumental variable regression indicate that the probability of households supplying labor tends to decrease once they are subjected to catastrophic health care expenses at both thresholds.
Recommendation The study recommends the implementation of policies that enhance financial protection for vulnerable groups. One such measure is the introduction of progressive taxation, which ensures that those with higher incomes contribute more to national revenue that can be in turn used to subsidize user fees.
Role of the OTAbZIP Gene in Regulating Growth and OTA Production in Aspergillus westerdijkiae fc-1 Under Osmotic Stress
Authors: Ma Yanling , Zhuang Muyuan , Ahmad Tanvir , Yan Yuhong , Yuan Weitian , Li Mingxuan , Tan Guangyou , Deng Yingyao , Liu Yang 
Published: January 2025

Abstract

Background
Ochratoxins are toxins primarily produced by fungi from the Aspergillus and Penicillium genera. Among these, Ochratoxin A (OTA) is the most toxic and exhibits strong carcinogenic effects. Reducing food contamination by OTA is a critical global challenge. Osmotic pressure is an important environmental factor that regulates various metabolic pathways in Aspergillus westerdijkiae. It particularly affects the HOG pathway, which controls fungal mycelium growth and OTA production. The OTAbZIP gene is a key transcription factor and receptor in A. westerdijkiae. It plays a vital role in responding to osmotic pressure and regulating the expression of OTA biosynthesis genes (otaA-D). This study explored the role of OTAbZIP in fungal growth and OTA production under different osmotic conditions using RNA-Seq and RT-qPCR analyses.
Results
Transcriptomic analysis showed that the OTAbZIP gene influences several pathways. These include DNA replication, sugar metabolism, ribosome function, and arginine and proline metabolism at NaCl concentrations of 0, 20, and 100 g/L. Genes in the high osmolarity glycerol, mitogen-activated protein kinase (MAPK HOG) pathway, such as Hog1, Gpd1, Cdc28, and Ctt1 were affected. The ΔOTAbZIP mutant strain exhibited increased sensitivity to osmotic stress. RT-qPCR results confirmed that OTA biosynthesis gene expression was significantly lower in the ΔOTAbZIP mutant strain than in the wild-type (WT) strain of A. westerdijkiae fc-1. However, the ΔOTAbZIP mutation did not affect the activation of the Hog1 gene.
Conclusions
This study highlights the role of the OTAbZIP gene in regulating metabolic pathways linked to growth and OTA production in A. westerdijkiae fc-1. These findings enhance our understanding of the gene's functions of A. westerdijkiae fc-1 under various somatic pressures. They also offer insights for developing strategies to control OTA contamination in food and feed.
Termite antimicrobial defense through interaction with symbiotic microorganisms in nest materials
Authors: Nakashima Masaaki , Matsuura Kenji 
Published: January 2025

Abstract

Social insects build robust nests to physically defend their colonies against attacks by predators and the intrusion of parasites and pathogens. While many previous studies on termite nests have focused on their physical defense functions, their nests also harbor various microorganisms that play a role in maintaining the colony’s hygienic environment. In this study, we report a dynamic defense mechanism of termite nests, where termites bury pathogen-infected corpses into the nest material, enhancing the antimicrobial defense provided by symbiotic bacteria inhabiting the nest. Termites buried pathogen-infected corpses, which could pose a high pathogenic risk, into the nest material, while they cannibalized corpses that were non-infected. In nest material where corpses were buried, the abundance of Streptomyces, antibiotic-producing bacteria, increased and enhanced the antifungal activity of the nest material. Furthermore, this Streptomyces inhibited the growth of termite pathogens and improved worker survival rates in the presence of these pathogens. These results suggest that the interaction between termites and nest-associated symbiotic bacteria, facilitated by corpse burial, contributes to the continuous maintenance of nest hygiene. This study elucidates the function of the nest as a 'living defensive wall' and enhances our understanding of the dynamic pathogen-defense systems employed by social insects.
Unveiling the Burden of Human Papillomavirus Infection and Risk Factors among indigenous Women in Mizoram, Northeast India
Authors: Colney Zomuanpuii , Laldinmawii Gracy , Singson Sangthang , Vanlalfeli Vanlalfeli , Chhangte Zirsangliana , Ngurbiakveli Cathrine , Lalduhchhungi Lalduhchhungi , Vanlalpeka Harvey , Lalrinfela Lalrinfela , Lalmuansangi Lalmuansangi , Lalngaihzuali Rebecca , Laltlanzovi Laltlanzovi , Lalremruata Lalremruata , Roy Swagnik 
Published: January 2025

Abstract

Introduction: Human Papillomavirus (HPV), a major cause of cervical cancer, poses a significant public health challenge globally, with its burden amplified in regionsamidst limited access to screening and preventive measures.
Method: This cross-sectional study investigates the prevalence of HPV infection and its associated risk factors among 1018 women from November 2023 to 2024 in Mizoram, India. The study integrates demographic, lifestyle, and clinical data, including DNA-based HPV genotyping and Pap smear analysis, to provide a comprehensive picture of HPV prevalence.
Results: This study screened 1,018 women aged between 20 and 73 years for HPV, with a mean age of 41 years. Findings reveal a 14.9% overall prevalence of HPV infection where most participants were from Mizoram's Aizawl District (78.78%). Betel nut consumption and early sexual debut were key lifestyle factors associated with higher infection risks. Chronic pelvic pain and multiple pregnancies were significant clinical indicators. HPV-16 (26.97%) and HPV-18 (17.11%) were the most prevalent genotypes. About 23.4% exhibited multiple genotype infections. Pap smear results revealed associations with high-grade squamous intraepithelial lesions (p=0.025).
Conclusion: The study underscores the importance of tailored public health strategies for high-risk regions like Mizoram. These include promoting HPV vaccination, enhancing screening programs, and addressing socio-cultural practices contributing to infection risks. Comprehensive interventions and awareness campaigns are crucial to mitigate the HPV burden and reducing cervical cancer incidence in this unique socio-demographic context.
Erythmelus klopomor: First steps toward classical biological control of the oak lace bug Corythucha arcuata, a dangerous invader in the European oak forests
Authors: PAULIN MÁRTON J. , MELIKA GEORGE , TRIAPITSYN SERGUEI , BECHTEL DAVID , CSÓKA GYÖRGY 
Published: January 2025

Abstract

The North American oak lace bug (OLB), Corythucha arcuata (Say, 1832) (Hemiptera: Tingidae), is a very dangerous invasive pest of European oaks (Quercus spp., Fagaceae). It was first detected in Europe in 2000 and currently occurs in 26 countries in the Palearctic region. Most Eurasian deciduous oaks are suitable host plants, therefore about 30 million hectares of oak dominated forests in Europe can facilitate its rapid spread. Its negative effects can be very diverse: decreasing photosynthetic activity, deteriorating health, decreasing acorn yield, negative effect on other oak herbivorous insects, and more. One of the main reasons for its rapid expansion is that native European predators, parasitoids and insect pathogens are unable to control it. The only feasible control option is a classical biological control program, the essence of which is to find and introduce a preferably specialist regulatory species that is effective in the pest’s native range. In July 2023 and in 2024, we collected oak leaves with OLB eggs from different locations in six states of the United States of America. All emerged egg parasitoids were preserved for later identification. Our initial observation was that collecting OLB eggs in the field proved to be more challenging than we first assumed. Overall, 23.7% of the samples contained parasitoids, with the average parasitism of 14.5%. Up to this point results indicate that the fairyfly Erythmelus klopomor Triapitsyn, 2007 (Hymenoptera: Mymaridae) is the only known egg parasitoid of OLB. Its host range is restricted to lace bugs, mainly Corythucha spp., and C. arcuata seems to be its preferred host. Our conclusion is that E. klopomor is a promising and only (at least so far) candidate for a classical biological control program, but further research efforts are unavoidable to clarify its life history parameters and minimize the risk of unintended non-target effects prior to a potential deliberate introduction to Europe.