bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case Study on Evaluation of Defect Characteristics for Practical Application of Appearance Inspection Work Support System Utilizing Deep Learning
Authors: Nakakura Yuta , Temizu Kosuke , Nishino Mana , Nakajima Ryosuke 
Published: April 2023

AbstractTo prevent outflow of defective products to customers, many manufacturing industries have focused not only on processing and assembling, but also on product inspection. In appearance inspection, a work support system using deep learning has been proposed, and its usefulness was experimentally shown in model images of industrial product in recent years. Therefore, in this study, aiming for practical application of work support system, the relationship between the lighting angles and the visibility of defects is experimentally evaluated using 80 actual automobile parts as a case study. As results, it is found that the visibility of the defect greatly differs depending on the angle of lighting, and the conditions for high visibility differ depending on the defect. Furthermore, it is found that it is possible to improve the visibility of defects in about 24% of all 80 automobile parts, but, it is difficult to improve the visibility of defects for the remaining 76%. From the above, for the practical application of the work support system, it is clarified that the importance of constructing of lighting condition optimization method to improve the visibility of defects, and examining the input image considering the visibility of defects for deep learning.
Framework for the Development and Implementation of Sustainable Information Systems for the Digitalization of Small Businesses in South Africa
Authors: Parker Ryan , Matope Stephen 
Published: April 2023

AbstractIn this paper, a framework for the development and implementation of a low-cost, “low-code”, information system, for the digitalization of small businesses, in the retail and manufacturing sectors is developed and employed. The purpose of this framework is to enable small businesses, that lack the technical expertise and financial resources to invest in proprietary information system technology, to develop systems by leveraging freely available cloud-based tools like Google Forms, Google Sheets, and Google Sites. A thorough literature review of the concept of digitalization is conducted. Thereafter, a small business suitable for digital transformation is identified. Based on the system requirements an information system relevant to the business is developed and implemented. Finally, guidelines are proposed for the development and implementation of similar systems in other small businesses.
Reducing Remanufacturing Uncertainties with the Digital Product Passport
Authors: Gallina Viola , Gal Barna , Szaller Ádám , Bachlechner Daniel , Ilie-Zudor Elisabeth , Sihn Wilfried 
Published: April 2023

AbstractIn contrast to the linear production model, the circular economy aims to close the loop of materials. One part of this approach is remanufacturing, which extends the lifetime of products. Various stakeholders in the supply chain are involved in remanufacturing. This makes the management and optimization of remanufacturing activities complex. The data required for optimization is often missing, which leads to uncertainties. A new European Commission initiative, the digital product passport (DPP), is believed to facilitate information exchange in the supply chain and cloud be a good solution to reduce uncertainties. The primary purpose of this paper is the quantification and evaluation of the advantages of the DPP. Based on real industrial data, a discrete event simulation model of a remanufacturing system with three production lines was developed. The authors suppose the hypothetical existence of a DPP and illustrate the benefits arising from its application.
Implementation Framework for Blockchain-Based Traceability to Tackle Drug-Counterfeiting: Embracing Sustainable Pharma Logistics Networks
Authors: Nitsche Benjamin , Straube Frank , Kämper Tom-Li , Zarnitz Simon 
Published: April 2023

AbstractFighting counterfeit drugs in pharma logistics networks, is one of the most important challenges in the industry. In order to contribute to the UN Sustainable Development Goal of “global health and well-being” the integration of counterfeit substances and drugs has to be stopped but is still causing significant human and economic damage. Although the problem is known for decades no approach is known that eradicates the problem. Blockchain technology is promoted as a potential solution to counterfeit drugs since it combines the properties of tamper-proof data storage and secure information transfer but its’ application in the pharma industry is still lacking behind the theoretical potential. This study seeks to assess the applicability of blockchain technology to tackle drug counterfeiting in pharma networks and to develop an implementation framework that outlines industry-specific implementation barriers and mitigation measures as well as their interdependencies. Building on nine interviews with industry experts, Grounded Theory was applied. Accordingly, the interview results were condensed into a theory by applying a three-stage coding process. Building on this analysis, an implementation framework for blockchain technology to tackle drug counterfeiting in the pharma industry is developed. The framework explains the enablers, barriers, and implementation strategies as well as the relation between them. It is shown that blockchain implementation is not hindered by a lack of technological maturity, but mostly by opposing incentive mechanisms of stakeholders involved.
Screening Life Cycle Assessment of Thermoacoustic Panels from Agricultural Byproducts
Authors: Salvador Rodrigo , Chapieski Gabriela Aparecida , Oshiro Leandro Inagaki , Sydney Eduardo Bittencourt , de Francisco Antonio Carlos 
Published: April 2023

AbstractThe objective of this study was to identify the main environmental impacts of thermoacoustic panels manufactured from agricultural byproducts and thereafter propose measures to improve the environmental performance of this product system. The life cycle assessment (LCA) technique was used to account for the environmental impacts in 10 impact categories. The environmental hotspots were the consumption of electricity at the manufacturing stage, and the use of wheat bran as main input. To improve the environmental performance of the system it was suggested the use of different feedstocks throughout the year, thus accounting for seasonality of agricultural byproducts. Another suggestion was to acquire more energy-efficient equipment, on their own or share the equipment with a partner, or acquire a specific energy mix from the local energy carrier or a third party.
Design for Sustainability in Manufacturing – Taxonomy and State-of-the-Art
Authors: Langer Vivien , Tampe Annika , Götze Uwe 
Published: April 2023

AbstractTo meet sustainability goals, manufacturing companies are faced with the challenge of using renewable resources as well as innovative processes to design and manufacture sustainable products. For this purpose, the Design for Sustainability (DfS) approach has been suggested. Since there is no uniform understanding of how such a concept should work and which methods should be applied within it, the paper is intended to provide an overview of existing approaches. Therefore, a taxonomy of DfS approaches is introduced to enable a systematic and differentiated analysis. Afterwards, a literature review is conducted and a comprehensive overview of DfS concepts is provided. This allows for uncovering research needs towards an established DfS approach.
TC-G 1008 facilitates epileptogenesis by acting selectively at the GPR39 receptor but non-selectively activates CREB in the hippocampus of pentylenetetrazole-kindled mice
Authors: Doboszewska Urszula , Socała Katarzyna , Pieróg Mateusz , Nieoczym Dorota , Sawicki Jan , Szafarz Małgorzata , Gawel Kinga , Rafało-Ulińska Anna , Sajnóg Adam , Wyska Elżbieta , Esguerra Camila V. , Szewczyk Bernadeta , Maćkowiak Marzena , Barałkiewicz Danuta , Mlyniec Katarzyna , Nowak Gabriel , Sowa Ireneusz , Wlaź Piotr 
Published: April 2023

AbstractThe pharmacological activation of the GPR39 receptor has been proposed as a novel strategy for treating seizures; however, this hypothesis has not been verified experimentally. TC-G 1008 is a small molecule agonist increasingly used to study GPR39 receptor function but has not been validated using gene knockout. Our aim was to assess whether TC-G 1008 produces anti-seizure/anti-epileptogenic effects in vivo and whether the effects are mediated by GPR39. To obtain this goal we utilized various animal models of seizures/epileptogenesis and GPR39 knockout mice model. Generally, TC-G 1008 exacerbated behavioral seizures. Furthermore, it increased the mean duration of local field potential recordings in response to pentylenetetrazole (PTZ) in zebrafish larvae. It facilitated the development of epileptogenesis in the PTZ-induced kindling model of epilepsy in mice. We demonstrated that TC-G 1008 aggravated PTZ-epileptogenesis by selectively acting at GPR39. However, a concomitant analysis of the downstream effects on the cyclic-AMP-response element binding protein in the hippocampus of GPR39 knockout mice suggested that the molecule also acts via other targets. Our data argue against GPR39 activation being a viable therapeutic strategy for treating epilepsy and suggest investigating whether TC-G 1008 is a selective agonist of the GPR39 receptor.
Positive Measure of Effective Quasi-Periodic Motion Near a Diophantine Torus
Authors: Bounemoura Abed , Farré Gerard 
Published: April 2023

AbstractIt was conjectured by Herman that an analytic Lagrangian Diophantine quasi-periodic torus $${\mathcal {T}}_0$$

T
0

, invariant by a real-analytic Hamiltonian system, is always accumulated by a set of positive Lebesgue measure of other Lagrangian Diophantine quasi-periodic invariant tori. While the conjecture is still open, we will prove the following weaker statement: there exists an open set of positive measure (in fact, the relative measure of the complement is exponentially small) around $${\mathcal {T}}_0$$

T
0

such that the motion of all initial conditions in this set is “effectively” quasi-periodic in the sense that they are close to being quasi-periodic for an interval of time, which is doubly exponentially long with respect to the inverse of the distance to $${\mathcal {T}}_0$$

T
0

. This open set can be thought of as a neighborhood of a hypothetical invariant set of Lagrangian Diophantine quasi-periodic tori, which may or may not exist.
Observability and control of parabolic equations on networks with loops
Authors: Apraiz Jone , Bárcena-Petisco Jon Asier 
Published: April 2023

AbstractNetwork theory can be useful for studying complex systems such as those that arise, for example, in physical sciences, engineering, economics and sociology. In this paper, we prove the observability of parabolic equations on networks with loops. By using a novel Carleman inequality, we find that the observability of the entire network can be achieved under certain hypothesis about the position of the observation domain. The main difficulty we tackle, due to the existence of loops, is to avoid entering into a circular fallacy, notably in the construction of the auxiliary function for the Carleman inequality. The difficulty is overcome with a careful treatment of the boundary terms on the junctions. Finally, we use the observability to prove the null controllability of the network and to obtain the Lipschitz stability for an inverse problem consisting on retrieving a stationary potential in the parabolic equation from measurements on the observation domain.
Density functional theory investigation of mechanisms of degradation reactions of sulfonated PEEK membranes with OH radicals in fuel cells: addition–elimination reactions and acid catalyzed water elimination
Authors: Stevens Jonathan E. , Pefley Courtney M. , Piatkowski Alice , Smith Zachary R. , Ognanovich Nikolina 
Published: April 2023

AbstractSulfonated polyether (ether) ketone or sulfonated PEEK (sPEEK) membranes are one possible candidate for proton-transfer membranes in hydrogen fuel cells. Reaction with hydroxy radicals is expected to be a significant source of degradation of these membranes during fuel cell operation. In this work, the reactivity of the sPEEK polymer molecule with OH radicals is studied by M062X hybrid density functional calculations of the energetics of several reaction paths in a water environment as modeled by polarized continuum model calculations. Reactants, products, encounter minima and transition states are optimized for a reaction pathway in which OH addition is followed by acid-catalyzed water elimination which cationizes the polymer, degradation is expected to follow this reaction as the unstable cation then undergoes bond-breaking or other reactions. Two pathways for this acid-catalyzed cationization, one in which a water molecule plays the role of an additional co-catalyst, are reported. Further calculations explore reaction pathways in which addition of OH to the polymer is followed by bond breaking reactions which would break the polymer chain or the bond between the polymer and sulfonyl groups. Examination of the free energy barriers to all these reactions, relative to reactants, suggests that these direct bond-breaking reactions may compete somewhat with acid-catalyzed water elimination following OH addition.
Changes in selected chemical and sensory parameters during aging of red wines produced in Poland
Authors: Zagrodzki Paweł , Jancik Michał , Piątek Wioleta , Fołta Maria , Dobrowolska-Iwanek Justyna 
Published: April 2023

AbstractThe study of the chemical composition of wines is of continuing interest to researchers, despite extensive knowledge about it. Many analyses focus on the chemical transformations that take place in this beverage as it ages. This study aimed to analyze changes in parameters such as free SO2 concentration, acidity, pH, the concentration of selected organic acids, total polyphenol concentration, and FRAP in five red wine varieties: Rondo, Regent, Cabernet Cortis, Acolon, and Zweigelt produced in Poland which were aged for 3 years. The study also included a sensory analysis of wines. The results indicated that, despite the relatively short aging time of the observed wine, the changes were significantly noticeable. The flavors of the wines, as well as their aromas, evolved, resulting in higher scores in sensory evaluation. Parameters such as free sulfur oxide (IV) concentration, antioxidant activity, and tartaric acid, acetic acid, and citric acid concentrations changed significantly. In addition, an analysis of the results was carried out using the PLS method, in which the relationships between the parameters determined were revealed. Research carried out indicates for the first time that Polish red wines have a relatively high potential for long aging.
Assessment of vestibulo-ocular reflex and its adaptation during stop-and-go car rides in motion sickness susceptible passengers
Authors: Ramaioli Cecilia , Steinmetzer Tobias , Brietzke Adrian , Meyer Paul , Pham Xuan Rebecca , Schneider Erich , Gorges Martin 
Published: April 2023

AbstractMotion sickness is a physiological condition that negatively impacts a person's comfort and will be an emerging condition in autonomous vehicles without proper countermeasures. The vestibular system plays a key role in the origin of motion sickness. Understanding the susceptibility and (mal) adaptive mechanisms of the highly integrated vestibular system is a prerequisite for the development of countermeasures. We hypothesize a differential association between motion sickness and vestibular function in healthy individuals with and without susceptibility for motion sickness. We quantified vestibular function by measuring the high-frequency vestibulo-ocular reflex (VOR) using video head impulse testing (vHIT) in 17 healthy volunteers before and after a 11 min motion sickness-inducing naturalistic stop-and-go car ride on a test track (Dekra Test Oval, Klettwitz, Germany). The cohort was classified as motion sickness susceptible (n = 11) and non-susceptible (n = 6). Six (out of 11) susceptible participants developed nausea symptoms, while a total of nine participants were free of these symptoms. The VOR gain (1) did not differ significantly between participant groups with (n = 8) and without motion sickness symptoms (n = 9), (2) did not differ significantly in the factor time before and after the car ride, and showed no interaction between symptom groups and time, as indicated by a repeated measures ANOVA (F(1,15) = 2.19, p = 0.16. Bayesian inference confirmed that there was “anecdotal evidence” for equality of gain rather than difference across groups and time (BF10 < 0.77). Our results suggest that individual differences in VOR measures or adaptation to motion sickness provocative stimuli during naturalistic stop-and-go driving cannot predict motion sickness susceptibility or the likelihood of developing motion sickness.
A Game Representation for a Finite Horizon State Constrained Continuous Time Linear Regulator Problem
Authors: Dower Peter M. , McEneaney William M. , Cantoni Michael 
Published: April 2023

AbstractA supremum-of-quadratics representation for a class of extended real valued barrier functions is developed and applied in the context of solving a continuous time linear regulator problem subject to a single state constraint of bounded norm. It is shown that this very simple state constrained regulator problem can be equivalently formulated as an unconstrained two-player game. By demonstrating equivalence of the upper and lower values, and exploiting existence and uniqueness of the optimal actions for both players, state feedback characterizations for the corresponding optimal policies for both players are developed. These characterizations are illustrated by a simple example.
Identification of Burkholderia cenocepacia non-coding RNAs expressed during Caenorhabditis elegans infection
Authors: Pita Tiago , Feliciano Joana R. , Leitão Jorge H. 
Published: April 2023

Abstract
Small non-coding RNAs (sRNAs) are key regulators of post-transcriptional gene expression in bacteria. Despite the identification of hundreds of bacterial sRNAs, their roles on bacterial physiology and virulence remain largely unknown, as is the case of bacteria of the Burkholderia cepacia complex (Bcc). Bcc is a group of opportunistic pathogens with relatively large genomes that can cause lethal lung infections amongst cystic fibrosis (CF) patients. To characterise sRNAs expressed by Bcc bacteria when infecting a host, the nematode Caenorhabditis elegans was used as an infection model by the epidemic CF strain B. cenocepacia J2315. A total of 108 new and 31 previously described sRNAs with a predicted Rho independent terminator were identified, most of them located on chromosome 1. RIT11b, a sRNA downregulated under C. elegans infection conditions, was shown to directly affect B. cenocepacia virulence, biofilm formation, and swimming motility. RIT11b overexpression reduced the expression of the direct targets dusA and pyrC, involved in biofilm formation, epithelial cell adherence, and chronic infections in other organisms. The in vitro direct interaction of RIT11b with the dusA and pyrC messengers was demonstrated by electrophoretic mobility shift assays. To the best of our knowledge this is the first report on the functional characterization of a sRNA directly involved in B. cenocepacia virulence.

Key points
• 139 sRNAs expressed by B. cenocepacia during C. elegans infection were identified
• The sRNA RIT11b affects B. cenocepacia virulence, biofilm formation, and motility
• RIT11b directly binds to and regulates dusA and pyrC mRNAs
Outcomes of patients with hematological malignancies who undergo unrelated donor hematopoietic stem cell transplantation with ATG-Fresenius versus ATG-Genzyme
Authors: Wang Lu , Kong Peiyan , Zhang Cheng , Gao Li , Zhu Lidan , Liu Jia , Gao Shichun , Chen Ting , Liu Huanfeng , Yao Han , Liu Yuqing , Feng Yimei , Zhao Lu , Li Yuxia , Gao Lei , Zhang Xi 
Published: April 2023

AbstractTo compare the outcomes of patients with hematological malignancies who received ATG-Fresenius (ATG-F) 20 mg/kg versus those who received ATG-Genzyme (ATG-G) 10 mg/kg in an unrelated donor hematopoietic stem cell transplantation (HSCT) procedure, a total of 186 patients who underwent their first allogeneic HSCT with an unrelated donor were retrospectively analyzed. One hundred and seven patients received ATG-F, and seventy-nine patients received ATG-G. Multivariate analysis showed that the type of ATG preparation had no effect on neutrophil engraftment (P = 0.61), cumulative incidence of relapse (P = 0.092), nonrelapse mortality (P = 0.44), grade II-IV acute graft-versus-host disease (GVHD) (P = 0.47), chronic GVHD (P = 0.29), overall survival (P = 0.795), recurrence-free survival (P = 0.945) or GVHD-free relapse-free survival (P = 0.082). ATG-G was associated with a lower risk of extensive chronic GVHD and a higher risk of cytomegaloviremia (P = 0.01 and HR = 0.41, P < 0.001 and HR = 4.244, respectively). The results of this study suggest that the preparation of rabbit ATG used for unrelated HSCT should be selected based on the incidence of extensive chronic GVHD of each center, and the posttransplant management strategy should be adjusted according to the ATG preparation.
A systematic review of the trophic ecology of eight ecologically and culturally important fish species in the North American Arctic
Authors: Wight Kevin J. , McNicholl Darcy G. , Dunmall Karen M. 
Published: April 2023

AbstractRapid climate change occurring in the Arctic may affect the diet of ecologically and culturally important northern fish species. Here, a systematic literature review was completed for eight fish species found across the North American Arctic, with a focus on Inuit Nunangat, to identify major prey items, summarize feeding strategies, and highlight data gaps. Arctic Char (Salvelinus alpinus), Dolly Varden Char (Salvelinus malma), Lake Trout (Salvelinus namaycush), Bull Trout (Salvelinus confluentus), Inconnu (Stenodus leucichthys), Lake Whitefish (Coregonus clupeaformis), Broad Whitefish (Coregonus nasus), and Burbot (Lota lota), were selected as species of interest due to their ecological and cultural importance. The 74 studies reviewed indicate that these species are generalist feeders that demonstrate wide dietary niches, as well as the tendency to avoid agonistic interactions by partitioning resources when they co-occur with an overlapping species. Across coastal, lacustrine, and riverine systems, the most commonly consumed prey items are insects (Diptera spp.), as well as benthic forage fishes such as sculpins (Family: Cottidae). Insects are major prey items in riverine systems, where diets appear to be more generalized, compared to lakes. Anadromous species in coastal waters most commonly feed on various crustaceans and forage fishes. Benthic forage fishes, insects, zooplankton, and mollusks are widely consumed prey items in Arctic lakes. Burbot, Inconnu, and resident Dolly Varden had the most specialized feeding strategies, due in part to their habitat requirements and morphology, while Lake Trout and resident Arctic Char often form multiple ecotypes in lakes, some with different feeding behaviors. Knowledge gaps regarding northern fish trophic ecology are highlighted, and in particular include riverine systems and winter foraging behavior. This review is intended to inform predictions regarding the impacts of climate change on fish tropic ecology and to guide future research.