bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in the quality and protein structure of steamed bread under different quick‐frozen temperatures
Authors: Zeng Jie , Shi Qingyang , Liang Keke , Wang Heng , Gao Haiyan 
Published: May 2023

AbstractBackground and ObjectivesThe quick‐frozen temperature may affect the quality of frozen food. The aim of this research was to investigate the effects of different quick‐frozen temperatures on the quality and protein structure of steamed bread.FindingsWith the decrease of quick‐frozen temperature, the water holding capacity and glutenin macropolymer content of frozen steamed bread increased, and the protein network structure in the steamed bread system was less damaged. A significant decrease of β‐sheet and random coils was found, from 48.6% to 39.4% and 24.1% to 21.9%, respectively. The significant decrease of A23 content and the melting enthalpy indicated that the frozen water content decreased and the bound water content in steamed bread increased. Steamed bread had higher springiness and cohesiveness at −32°C and −36°C.ConclusionsThe quality of steamed breads was better when quick‐frozen temperatures were at −32°C and −36°C. Therefore, from the perspective of more energy saving and environmental protection, steamed bread can be rapidly frozen at −32°C.Significance and NoveltyDifferent quick‐frozen temperatures have different effects on each index of steamed bread, which provides a certain theoretical basis for the quick‐frozen process of steamed bread.
Unexpected Coexisting Solid Solutions in the Quasi‐Binary Ag(II)F2/Cu(II)F2 Phase Diagram**
Authors: Jezierski D. , Koteras K. , Domański M. , Połczyński P. , Mazej Z. , Lorenzana J. , Grochala W. 
Published: May 2023

AbstractHigh‐temperature solid‐state reaction between orthorhombic AgF2 and monoclinic CuF2 (y=0.15, 0.3, 0.4, 0.5) in a fluorine atmosphere resulted in coexisting solid solutions of Cu‐poor orthorhombic and Cu‐rich monoclinic phases with stoichiometry Ag1−xCuxF2. Based on X‐ray powder diffraction analyses, the mutual solubility in the orthorhombic phase (AgF2 : Cu) appears to be at an upper limit of Cu concentration of 30 mol % (Ag0.7Cu0.3F2), while the monoclinic phase (CuF2 : Ag) can form a nearly stoichiometric Cu : Ag=1 : 1 solid solution (Cu0.56Ag0.44F2), preserving the CuF2 crystal structure. Experimental data and DFT calculations showed that AgF2 : Cu and CuF2 : Ag solid solutions deviate from the classical Vegard's law. Magnetic measurements of Ag1−xCuxF2 showed that the Néel temperature (TN) decreases with increasing Cu content in both phases. Likewise, theoretical DFT+U calculations for Ag1−xCuxF2 showed that the progressive substitution of Ag by Cu decreases the magnetic interaction strength |J2D| in both structures. Electrical conductivity measurements of Ag0.85Cu0.15F2 showed a modest increase in specific ionic conductivity (3.71 ⋅ 10−13±2.6 ⋅ 10−15 S/cm) as compared to pure AgF2 (1.85 ⋅ 10−13±1.2 ⋅ 10−15 S/cm), indicating the formation of a vacancy‐ or F adatom‐free metal difluoride sample.
Lanthanide Functionalized Covalent Organic Frameworks Hybrid Materials for Luminescence Responsive Chemical Sensing
Authors: Yan Bing 
Published: May 2023

AbstractCovalent organic frameworks (COFs) possess several unique features of structural and functional chemistry, together with other modular photophysical performance, which make them candidates for luminescence responsive chemical sensing. Lanthanide (Ln3+) functionalized COFs hybrid materials still keep the parent COFs’ virtues and also embody the abundant multiple luminescence response with both COFs and Ln3+ ions or other guest species. In this review, the summary is highlighted on the lanthanide functionalized COFs hybrid materials and their relevant systems for luminescence responsive chemical sensing. It is subdivided into five sections involving the three main topics. Firstly, the basic knowledges of COFs materials related to the luminescence responsive chemical sensing are introduced (including three sections), involving the chemistry, application and post‐synthetic modification (PSM) of COFs, the luminescence and luminescence responsive chemical sensing, and the luminescence responsive chemical sensing of non‐lanthanide functionalized COFs hybrids materials. Secondly, the systematic progresses are outlined on the lanthanide functionalized COFs hybrid materials in luminescence responsive chemical sensing, which is the emphasis for this review. Finally, the conclusion and prospect are given.
Flowrate effects on the lateral coalescence of two growing bubbles
Authors: Feng Ximin , Kunugi Tomoaki , Qin Shijie , Wu Dazhuan 
Published: May 2023

AbstractThe coalescence of two growing bubbles presents unique characteristics compared to static bubble coalescence. The gas injection flowrate significantly affects the different stages of bubble evolution, which is poorly understood. In this study, we investigate the flowrate effects on the lateral coalescence of two growing bubbles experimentally. The synchronous bubbling from adjacent needles is achieved using water to push air. During the bubble growth process, we find that the initial nonlinear evolution of bubble volume is because the bubble emerges as a small spherical cap with a large curvature radius and apparent contact angle. As the neck expands after bubble coalescence, the injection flowrate accelerates the neck evolution compared to the case without air injection. We find the neck expansion time decreases linearly with increasing flowrate, while the expansion speed increases with flowrate, but only in the early stage. Moreover, we propose a new theoretical expression that predicts the neck radius well at all the flowrates. At the post‐coalescence oscillation stage, the average projection area of the coalesced bubble increases linearly with time, except for periodic oscillations. Besides, we find that the injected air primarily influences the coalesced bubble's height, which in turn affects the projection area.
Association of race and in‐hospital outcomes following acute pulmonary embolism: A retrospective cohort study
Authors: Sullivan Alexander E. , Barbery Carlos E. , Holder Tara , Green Cynthia L. , Patel Manesh R. , Thomas Kevin L. , Jones W. Schuyler 
Published: May 2023

AbstractBackgroundRacial disparities in health care are well established, with Black patients frequently experiencing the most significant consequences of this inequality. Acute pulmonary embolism (PE) is increasing in incidence and an important cause of morbidity and mortality in the United States, but little is known about racial disparities in the inpatient setting.HypothesisBlack and White patients admitted with acute PE will have different in‐hospital outcomes.MethodsAll PE patients from January 1, 2016 to June 30, 2017 were retrospectively identified using ICD‐10 codes. Data were abstracted by manual chart review for all image‐confirmed PEs.ResultsA total of 782 patients with acute PE were identified, of which 319 (40.8%) were Black and 463 (59.2%) were White. Black patients had higher BMI (median [Q1–Q3]: 30.3 [25.4–36.6] vs. 29.3 [24.5–33.8] kg/m2, p = .017), were younger (61 [48–74] vs. 67 [54–75] years, p = .001), and were more likely to have a history of heart failure (16.0 vs. 7.1%, p < .001), while White patients had higher rates of malignancy (46.9 vs. 34.5%, p = .001) and recent surgery (29.6 vs. 18.2%, p < .001). Black patients were more likely to receive systemic thrombolysis (3.1% vs. 1.1%, p = .040), while White patients had numerically higher rates of surgical embolectomy (0.3% vs. 1.1%, p = .41). No difference in inpatient mortality was observed; however, Black patients had longer hospital length of stay (5.0 [3–9] vs. 4.0 [2–9] days, p = .007) and were more likely to receive warfarin (23.5 vs. 12.1%, p < .001).ConclusionsSimilar in‐hospital mortality rates were observed in Black and White patients following acute PE. However, Black patients had longer hospital stays, higher warfarin prescription, and fewer traditional PE‐related risk factors.
Pancreatic hamartoma: Possibility of a preoperative diagnosis via endoscopic ultrasound–guided fine‐needle aspiration biopsy
Authors: Shintaku Hiroshi , Gokita Kentaro , Oshima Takumi , Suzuki Kenta , Fujii Keiko , Sugaya Noriko , Tomii Shohei , Onishi Iichiroh , Shimada Ken , Ohashi Kenichi 
Published: May 2023

AbstractEndoscopic ultrasound–guided fine‐needle aspiration biopsy (EUS–FNAB) is useful for preoperatively diagnosing various pancreatic tumors. Although there is a risk of complications, such as pancreatitis, this procedure achieves the crucial need of reducing unnecessary invasive surgery for benign lesions. Herein, we reported a surgically resected case of pancreatic hamartoma in the pancreatic head whose retrospective analysis revealed that the specimens obtained via EUS–FNAB contained hamartoma fragments. Pancreatic hamartoma is an extremely rare benign disease that is exceptionally difficult to diagnose before surgical resection owing to its rarity and lack of established imaging findings. To the best of our knowledge, the preoperative diagnosis of pancreatic hamartoma via EUS–FNAB specimens has not been reported to date. Herein, postoperative EUS–FNAB evaluation revealed a collection of pancreatic hamartoma lesions, although the initial diagnosis was pancreatic tissue with focal atrophy and fibrosis. Diagnosis using EUS–FNAB can be challenging owing to the very small sample size. If mature acini and ducts with fibrous stroma without islets are observed in the EUS–FNAB specimen, pancreatic hamartoma should be considered as a differential diagnosis. Thus, careful follow‐up or reexamination of EUS–FNAB should be considered instead of surgery if a benign lesion is suspected preoperatively.
Aryl Crown Ethers Based on d‐Glucose Scaffold – Highly Selective Receptors of Amino Acid Ester Hydrochlorides
Authors: Chak Man Him , Schnurr Martin , Lewandowski Bartosz 
Published: May 2023

AbstractAmino acids are important biomolecules with a broad scope of applications in chemical and biological sciences. Their functions and properties depend on their absolute configuration. Therefore, methods for chiral recognition and separation of amino acids are highly sought after. For the purposes of diagnostic and medicinal applications chiral recognition of amino acids in water is particularly relevant. However synthetic receptors for enantioselective binding of amino acids in aqueous media are rare. Recently we reported a d‐glucose‐based crown ether for chiral recognition of amino acid esters in water. We achieved enantioselectivities towards amino acids with hydrophobic sidechains which were among the highest ever reported for a small molecule receptor. The binding affinities were however moderate. Herein we disclose analogs of that receptor, containing aryl functionalities in the crown ether fragment. The new receptors show considerably improved binding affinities for amino acid ester hydrochlorides in water, while retaining high enantio‐ or chemoselectivities.
Diastereoselective and Enantioselective Synthesis of Multi‐Functionalized Isoxazoline‐N‐Oxides through Asymmetric [4+1] Annulations
Authors: Wang Mengzhou , Wang Jing , Shen Wen , Xie Xuan‐sheng , Qi Liang , Xie Jian‐wu 
Published: May 2023

AbstractA diastereoselective and enantioselective formal [4+1] ylide annulation of chiral sulfonium salts with various substituted Morita‐Baylis‐Hillman (MBH) adducts leading to optically active isoxazolineN‐oxides with three chiral carbon centers has been explored. The salient features of this methodology include a high diastereo‐ and enantioselective transformation, easily accessible starting materials, and mild reaction conditions. In addition, the isoxazolineN‐oxides products can be conveniently transformed into functionalized compounds.
Pain‐free default mode network connectivity contributes to tonic experimental pain intensity beyond the role of negative mood and other pain‐related factors
Authors: Alhajri Najah , Boudreau Shellie Ann , Mouraux André , Graven‐Nielsen Thomas 
Published: May 2023

AbstractBackgroundAlterations in the default mode network (DMN) connectivity across pain stages suggest a possible DMN involvement in the transition to persistent pain.AimThis study examined whether pain‐free DMN connectivity at lower alpha oscillations (8‐10 Hz) accounts for a unique variation in experimental peak pain intensity beyond the contribution of factors known to influence pain intensity.MethodsPain‐free DMN connectivity was measured with electroencephalography prior to 1 h of capsaicin‐evoked pain using a topical capsaicin patch on the right forearm. Pain intensity was assessed on a (0–10) numerical rating scale and the association between peak pain intensity and baseline measurements was examined using hierarchical multiple regression in 52 healthy volunteers (26 women). The baseline measurements consisted of catastrophizing (helplessness, rumination, magnification), vigilance, depression, negative and positive affect, sex, age, sleep, fatigue, thermal and mechanical pain thresholds and DMN connectivity (medial prefrontal cortex [mPFC]‐posterior cingulate cortex [PCC], mPFC‐right angular gyrus [rAG], mPFC‐left Angular gyrus [lAG], rAG‐mPFC and rAG‐PCC).ResultsPain‐free DMN connectivity increased the explained variance in peak pain intensity beyond the contribution of other factors (ΔR2 = 0.10, p = 0.003), with the final model explaining 66% of the variation (R2 = 0.66, ANOVA: p < 0.001). In this model, negative affect (β = 0.51, p < 0.001), helplessness (β = 0.49, p = 0.007), pain‐free mPFC‐lAG connectivity (β = 0.36, p = 0.003) and depression (β = −0.39, p = 0.009) correlated significantly with peak pain intensity. Interestingly, negative affect and depression, albeit both being negative mood indices, showed opposing relationships with peak pain intensity.ConclusionsThis work suggests that pain‐free mPFC‐lAG connectivity (at lower alpha) may contribute to individual variations in pain‐related vulnerability.SignificanceThese findings could potentially lead the way for investigations in which DMN connectivity is used in identifying individuals more likely to develop chronic pain.
A staged approach to oromandibular reconstruction using the iliac crest free flap in the setting of bilateral failed fibula free flaps
Authors: Dowling Eric , Okay Devin J. , Saturno Michael P. , Greenberg Lily A. , Buchbinder Daniel , Urken Mark L. 
Published: May 2023

AbstractBackgroundWhile a single‐stage free‐flap reconstruction is the preferred approach for oromandibular defects, a multistaged approach may be necessary in rare cases. These patients can still be effectively restored with functional and aesthetic improvements.MethodsWe report two cases with a history of bilateral failed fibula free flaps. We detail the multistaged reconstruction to repair these complex defects and discuss the considerations when planning such procedures.ResultsBoth patients successfully underwent a staged reconstruction with an iliac crest osteocutaneous flap following either a rectus abdominis or pectoralis major myocutaneous flap.ConclusionOromandibular reconstruction is an expected outcome in the contemporary management of oral cavity cancer and osteoradionecrosis. However, complications do occur and can be devastating. In cases of bilateral failed fibula free flaps, a staged approach is a favorable option. Moreover, the iliac crest provides an important reconstructive option with the documented potential for implant born dental rehabilitation.
Long‐term depression induction and maintenance across regions of the apical branch of CA1 dendrites
Authors: Parvez Suhel , Ramachandran Binu , Kaushik Medha , Tabassum Heena , Frey Julietta U. 
Published: May 2023

AbstractWell known as the center for learning and memory, hippocampus is the crucial brain region to study synaptic plasticity in the context of cellular fundamental mechanisms such as long‐term depression (LTD) and long‐term potentiation (LTP). However, despite years of extensive research, the key to our LTD queries and their induction mechanisms has not been fully understood. Previously, we reported the induction of late‐LTD (L‐LTD) in the distally located synapses of apical branch of hippocampal CA1 dendrites using strong low‐frequency stimulation (SLFS). In contrast synapses at the proximal site could not express L‐LTD. Thus, in the present study, we wanted to investigate whether or not synapses of apical dendritic branch at the proximal location could induce and maintain LTD and its related properties in in vitro rat hippocampal slices. Results indicated that the SLFS in the distal and proximal region triggered the plasticity related proteins (PRP) synthesis in both regions, as evident by the induction and maintenance of L‐LTD in the distal region by virtue of synaptic and cross‐tagging. In addition, the application of emetine at the time of proximal input stimulation prevented the transition of early‐LTD (E‐LTD) into L‐LTD at the distal region, proving PRP synthesis at the proximal site. Further, it was observed that weak low‐frequency stimulation (WLFS) could induce E‐LTD in the proximal region along with LTD‐specific tag‐setting at the synapses. In conclusion, the current study suggests unique findings that the synaptic and cross‐tagging mediate L‐LTD expression is maintained in the proximal location of hippocampus apical CA1 dendrites.
Fertigation under different irrigation and nitrogen levels modulates the growth, physiology, nitrogen and fruit productivity of greenhouse tomato
Authors: Rasool Ghulam , Guo Xiangping , Wang Weiguang , Zhang Shuxuan 
Published: May 2023

AbstractExperiments were conducted to evaluate the interactive effects of different nitrogen and irrigation levels in 2017 and 2018 (April–July) on greenhouse‐grown tomato considering irrigation water, growth, physiology and productivity parameters. A randomized block design with three replications and two factors, water (W1, 100% of the requirement; W2, 90%; W3, 70%) and nitrogen fertilizer (F1 225 kg/ha, F2 180 kg/ha), was established. The highest values of crop consumptive use (ET) were observed under the W1F1 treatment during both seasons (266 and 226 mm during 2017 and 2018, respectively). The highest values of stem and root biomass were also observed under W1F1 during both experimental seasons, followed by W1F2 and W2F1, without significant differences. Compared with W1F1, W1F2 and W2F1 had no significant difference, but other treatments decreased the photosynthesis rate and stomatal conductance significantly during both seasons. The highest irrigation level, W1, increased fruit yield under both nitrogen levels (W1F1 yielded 91 and 102 t ha−1, followed by W1F2, with 90 and 99 t ha−1 during 2017 and 2018, respectively). W2 increased fruit yield under higher nitrogen levels (F1) but decreased fruit yield under lower nitrogen levels (F2). W3 decreased yield drastically under both nitrogen levels. W3 significantly decreased water use efficiency and irrigation water use efficiency. The highest partial factor productivity values of 23% and 22% were obtained under W1F2 in 2017 and 2018, respectively, when compared with the control treatment. It was concluded that W1F2 could be the best strategy for improving greenhouse‐grown tomato productivity.
Antiviral effect of Favipiravir against Chandipura virus in vitro and in vivo
Authors: Pavitrakar Daya V. , Bondre Vijay P. 
Published: May 2023

AbstractChandipura virus (CHPV) is an emerging encephalitic virus with outbreak potential in a pediatric population. It causes acute encephalitis, with clinical symptoms leading to death within 48–72 h and an alarmingly high case fatality rate up to 55%–78%. Despite the high mortality rate in children, no vaccines or antivirals are currently available; thus, repurposing licensed drugs seems to be one of the attractive therapeutic approaches. Among the various options available, Favipiravir emerged as a promising candidate, and its unique characteristics and clinical efficacy have garnered significant attention and demonstrated considerable potential in the fight against viral diseases. In the current study, we have evaluated the antiviral effect of Favipiravir against CHPV by Plaque reduction assay and viral growth kinetics assay in Vero cells and in vivo effect of drug treatment against lethal viral challenge was analysed in 10‐day‐old CD1 mice. A dose‐dependent reduction in CHPV plaque size and number was observed in Vero cells treated with Favipiravir, with an EC50 of 92.26 μM. Complete inhibition of CHPV replication was observed at 320 μM drug concentration and 50% cytotoxicity (CC50) at 4774 μM, indicating a high selectivity index 51.24. In vivo, studies in mice showed 100% survival with 300 mg/kg/day of Favipiravir given orally till seventh‐day postinfection. The study provides evidence of the antiviral activity of Favipiravir against CHPV infection, and further clinical evaluation may alleviate the associated mortality.
Foraminifera assemblages from Fantangisña serpentinite mud seamount in the NW Pacific Ocean during the Pleistocene (IODP Expedition 366)
Authors: Del Gaudio Arianna V. , Piller Werner E. , Auer Gerald , Kurz Walter 
Published: May 2023

ABSTRACTThe Mariana forearc system, in the northwestern Pacific, is known as the only convergent margin setting with currently active serpentine mud volcanism. The Fantangisña serpentinite mud volcano lies 62 km west of the Mariana trench, within the influence of the North Equatorial Current (NEC). Cores recovered by International Ocean Discovery Program (IODP) Expedition 366 contain pelagic sediments overlying layered serpentinite mud deposits. At the bottom of the sequence, nannofossil‐rich forearc deposits were recovered from under the seamount edifice. In this study, we investigated 47 samples from Site U1498A on the southern flank of the seamount for benthic and planktonic foraminifera assemblages. Statistical analyses on planktonic assemblages differentiated two sample groups related to the ratio between thermocline/mixed layer taxa, which indicate fluctuations in the depth of the thermocline (DOT) during the Pleistocene. Variations in the DOT reflect changes in the intensity of the NEC associated with El Niño/La Niña conditions. Mudflows do not influence the ecology of planktonic foraminifera but possibly enhance their preservation against dissolution, which was instead detected in the pelagic deposit as suggested by commonGlobigerinoides conglobatus. Benthic foraminifers were rare in serpentinite mud deposits as they are severely affected by mudflows. Conversely, they showed high diversity pre‐/post‐mud‐volcanism, and indicate oligotrophic bottom‐water conditions.