bluuebunny/crossref_metadata_2025_split huggingface dataset:
Moving Bermudagrass into Temperate Regions
Authors: Baxter Lisa 
Published: May 2023

AbstractGeorgia has been historically dominated by two perennial forage grass production systems: tall fescue in the north and bermudagrass in the south. Climatologists have documented notable changes in temperature and precipitation patterns in the state that have contributed to an invasion of warm‐season species in the northern portion of the state. This article documents the expansion of warm‐season bermudagrass into northern Georgia, explores the climatic factors driving this transition, and highlights previous and ongoing research. Earn 0.5 CEUs in Crop Management by reading this article and taking the quiz at https://web.sciencesocieties.org/Learning‐Center/Courses.
Single‐Strip Spatial Evaluation Approach for Easier, More Meaningful On‐Farm Research
Authors: Srinivasagan Subhashree , Tanchez Juan Carlos Ramos , Marcaida Manuel , Shajahan Sunoj , Workman Kirsten , Ketterings Quirine 
Published: May 2023

AbstractOn‐farm research helps farmers make more informed management decisions in their operations for increased productivity and sustainability. While conventional on‐farm research designs are scientifically sound, the power to determine significant differences among various treatments is limited by the number of replications that can be put in place (more replications increase the chance to detect differences). In addition, major barriers to adoption of on‐farm research have been the space (larger fields) and the time required to conduct trials during planting and harvest. As these logistical and potentially economic challenges might discourage farmers from engaging in on‐farm research and be part of on‐farm research networks, a new way to conduct trials was developed that makes use of yield monitor technology and advances in spatial statistics. Earn 0.5 CEUs in Crop Management by reading this article and taking the quiz at https://web.sciencesocieties.org/Learning‐Center/Courses.
A quantitative risk assessment approach for developing contingency plans at a geologic carbon storage site
Authors: Mitchell Nate , Lackey Greg , Schwartz Brandon , Strazisar Brian , Dilmore Robert 
Published: May 2023

AbstractGeologic carbon storage (GCS) is an increasingly important technology for reducing carbon dioxide (CO2) emissions to the atmosphere. The leakage risks associated with GCS are an environmental and human health concern, however, and site operators must develop contingency plans that thoroughly consider leakage risks and identify potential mitigation strategies. Here, we use a GCS system model (the National Risk Assessment Partnership's Open‐Source Integrated Assessment Model, NRAP‐Open‐IAM) to evaluate different contingency plans for a hypothetical GCS site. In the scenario considered, an unplugged legacy well is discovered near the site after 5 years of CO2 injection. Our simulations show that the planned operation has a relatively high chance of causing brine leakage through the legacy well and into the two overlying aquifers, the shallower of which has potable water—an unacceptable outcome. To reduce this risk, we consider five remedial response scenarios that manipulate reservoir pressures through brine extraction, injection rate reduction, and early injection stopping. NRAP‐Open‐IAM is used to quantify the degree to which each scenario reduces the probability of brine leakage at the site amidst reservoir uncertainty. Evaluation of the different scenarios suggests that reduction of injection rates effectively reduces leakage risks while maintaining a substantial fraction of the initially intended cumulative CO2 storage. In the event of an emergency, the reservoir pressure management strategies considered here can provide operators more time while they pursue a more permanent solution. The analyses demonstrated here fit into a larger workflow we propose for evaluating the contingency plans of GCS sites. © 2023 Society of Chemical Industry and John Wiley & Sons, Ltd.
A qualitative exploration of caregivers’ experiences with the Attachment and Biobehavioral Catch‐up (ABC) parenting program
Authors: Bagwell‐Gray Meredith E. , Grube Whitney , Mendenhall Amy , Jen Sarah , Olaleye Omowunmi , Sattler Patricia 
Published: May 2023

AbstractIn the face of childhood adversity, services and interventions can improve a child's life trajectory by promoting healthy development, enhancing protective factors, and building resilience through stable and supportive relationships. One such service, a specific and highly researched home visiting intervention, Attachment and Biobehavioral Catch‐up (ABC), is often provided to families through home visiting service programs. This qualitative descriptive study examines the experiences of caregivers (N = 18) who received ABC as part of a statewide early childhood initiative in one midwestern state. Participants provided insight into the context of their lives before and during the intervention. They described their perspectives of the utility of the program and its influence on their family's behaviors and interactions. Findings demonstrate that coaching support bolstered caregivers’ confidence in effective strategies and guided them through caregiving challenges. Caregivers observed growth in their caregiving practices, their infants’ and young children's social and emotional skills, and their dyadic caregiver‐child relationships, demonstrating the benefits of participating in and completing the ABC intervention.
Evaluation of the effect of vitamin D level on greater tuberosity primary bone marrow edema
Authors: Başbuğ Veysel , Yaka Haluk , Tekin Alper Aziz , Duman Numan , Demiryürek Mehmet , Özer Mustafa 
Published: May 2023

AbstractIntroductionThe anabolic effects of vitamin D on bone tissue have been demonstrated in experimental studies. The aim of this study was to evaluate the relationship between greater tuberosity primary bone marrow edema (GTPBMO) and vitamin D levels.Materials and MethodsThirty‐nine patients (22 females and 17 males; mean age 49.02 ± 13.08 years) with isolated GTPBMO between March 2016 and March 2018 were included in the study. Sixty patients (34 females and 26 males; mean age 43.45 ± 12.61 years) who did not have any shoulder complaints and fulfilled the study criteria were selected as the control group. Both groups were compared in terms of vitamin D levels.ResultsThe mean vitamin D level was 13.43 ± 9.02 ng/mL in the GTPBMO group. In contrast, mean vitamin D level was 21.54 ± 8.03 ng/mL in the control group (p < 0.001). In the GTPBMO group, vitamin D deficiency was detected in 31 (79.5%) patients, vitamin D insufficiency was detected in 5 (12.8%) patients, and vitamin D levels were normal in 3 (7.7%) patients. In the control group, vitamin D deficiency was detected in 29 (48.3%) patients, vitamin D insufficiency was detected in 16 (26.7%) patients, and vitamin D levels were normal in 15 (25%) patients.ConclusionThe etiology of GTPBMO has not yet been fully understood, but the results obtained in this study show that vitamin D levels were significantly lower in patients with GTPBMO. The findings suggest that low vitamin D levels may be one of the contributing factors in the etiology of GTPBMO.
In situ thermo‐Raman spectroscopy and ab initio vibrational assignment calculations of cubanite CuFe2S3
Authors: Pankrushina Elizaveta A. , Votyakov Sergey L. , Aksenov Sergey M. , Komleva Evgenia V. , Uporova Natalya S. , Vaitieva Yulia A. 
Published: May 2023

AbstractIn situ thermo‐Raman spectroscopy is used to study a single crystal of natural orthorhombic cubanite from the Talnakh copper‐nickel sulfide deposit (Norilsk, Russia). The dependence of the wavenumbers and FWHMs of vibrational modes on temperature, including the cubanite → isocubanite phase transition region, is studied in the range of 83–873 K. For the first time, the polarized Raman spectra of cubanite have been interpreted according to ab initio calculations performed using the density functional theory (DFT) implemented in the VASP package. In spite of the tetrahedral environment of Cu and Fe atoms in cubanite, the spectra demonstrate the presence of different types of bending (twisting, wagging, scissoring, etc.) and stretching vibrations in two different triatomic (S2‐Cu‐S2) and (Fe‐S1‐Fe) fragments for Ag and B2g symmetries, and in three‐ and four‐atomic (S1‐Cu‐S1) and FeS(2)3 fragments, respectively, for B1g and B3g symmetries.
Body composition profiling at 0.55T: Feasibility and precision
Authors: Nayak Krishna S. , Cui Sophia X. , Tasdelen Bilal , Yagiz Ecrin , Weston Sarah , Zhong Xiaodong , Ahlgren André 
Published: May 2023

PurposeBody composition MRI captures the distribution of fat and lean tissues throughout the body, and provides valuable biomarkers of obesity, metabolic disease, and muscle disorders, as well as risk assessment. Highly reproducible protocols have been developed for 1.5T and 3T MRI. The purpose of this work was to demonstrate the feasibility and test–retest repeatability of MRI body composition profiling on a 0.55T whole‐body system.MethodsHealthy adult volunteers were scanned on a whole‐body 0.55T MRI system using the integrated body RF coil. Experiments were performed to refine parameter settings such as TEs, resolution, flip angle, bandwidth, acceleration, and oversampling factors. The final protocol was evaluated using a test–retest study with subject removal and replacement in 10 adult volunteers (5 M/5F, age 25–60, body mass index 20–30).ResultsCompared to 1.5T and 3T, the optimal flip angle at 0.55T was higher (15°), due to the shorter T1 times, and the optimal echo spacing was larger, due to smaller chemical shift between water and fat. Overall image quality was comparable to conventional field strengths, with no significant issues with fat/water swapping or inadequate SNR. Repeatability coefficient of visceral fat, subcutaneous fat, total thigh muscle volume, muscle fat infiltration, and liver fat were 11.8 cL (2.2%), 46.9 cL (1.9%), 14.6 cL (0.5%), 0.1 pp (2%), and 0.2 pp (5%), respectively (coefficient of variation in parenthesis).ConclusionsWe demonstrate that 0.55T body composition MRI is feasible and present optimized scan parameters. The resulting images provide satisfactory quality for automated post‐processing and produce repeatable results.
Robust breast quantitative susceptibility mapping in the presence of silicone
Authors: Böhm Christof , Stelter Jonathan K. , Weiss Kilian , Meineke Jakob , Komenda Alexander , Borde Tabea , Makowski Marcus R. , Fallenberg Eva M. , Karampinos Dimitrios C. 
Published: May 2023

PurposeTo (a) develop a preconditioned water–fat–silicone total field inversion (wfsTFI) algorithm that directly estimates the susceptibility map from complex multi‐echo data in the breast in the presence of silicone and to (b) evaluate the performance of wfsTFI for breast quantitative susceptibility mapping (QSM) in silico and in vivo in comparison with formerly proposed methods.MethodsNumerical simulations and in vivo multi‐echo gradient echo breast measurements were performed to compare wfsTFI to a previously proposed field map‐based linear total field inversion algorithm (lTFI) with and without the consideration of the chemical shift of silicone in the field map estimation step. Specifically, a simulation based on an in vivo scan and data from five patients were included in the analysis.ResultsIn the simulation, wfsTFI is able to significantly decrease the normalized root mean square error from lTFI without (4.46) and with (1.77) the consideration of the chemical shift of silicone to 0.68. Both the in silico and in vivo wfsTFI susceptibility maps show reduced shadowing artifacts in local tissue adjacent to silicone, reduced streaking artifacts and no erroneous single voxels of diamagnetic susceptibility in proximity to silicone.ConclusionThe proposed wfsTFI method can automatically distinguish between subjects with and without silicone. Furthermore wfsTFI accounts for the presence of silicone in the QSM dipole inversion and allows for the robust estimation of susceptibility in proximity to silicone breast implants and hence allows the visualization of structures that would otherwise be dominated by artifacts on susceptibility maps.
Destroyed bladders: Characterization of progressive inflammatory cystitis
Authors: Faris Anna , Lane Giulia I. , Mehra Rohit , Dadhania Vipulkumar , Crescenze Iryna , Clemens J. Quentin , Romo Paholo Barboglio , Stoffel John , Malaeb Bahaa , Blair Yooni , Goh Meidee , Gupta Priyanka , Cameron Anne P. 
Published: May 2023

AbstractPurposeWe identified a subset of patients with noninfectious cystitis who develop refractory symptoms marked by diffuse inflammatory changes, reduced bladder capacity, and vesicoureteral reflux (VUR), termed here as “progressive inflammatory cystitis” (PIC). Our objective was to describe the phenotype, disease outcomes, and pathologic findings of PIC.Material and MethodsA single institution retrospective cohort study of patients with PIC. Patients with a history of pelvic radiation, urologic malignancy, or neurogenic bladder were excluded. We describe cohort characteristics and use bivariate analyses to compare subgroups. Kaplan–Meier methods estimate time to urinary diversion.ResultsFrom 2008 to 2020, 46 patients with PIC were identified. The median age of symptom onset was 63 years old (interquartile range [IQR]: 56, 70) and the most common presenting symptoms were urinary urgency/frequency (54%) and incontinence (48%). Urodynamics showed a median maximum bladder capacity of 80 mL (IQR: 34, 152), commonly with VUR (68%) and hydronephrosis (59%). Ultimately 36 patients (78%) underwent urinary diversion at a median of 4.5 years (IQR: 2, 6.5) after symptom onset. Significant pathologic findings include presence of ulceration (52%), acute and chronic inflammation (68%), including eosinophils (80%), lymphoid follicles (56%), and mast cells in both lamina and muscularis propria (76%).ConclusionsPIC is a newly defined entity characterized by significantly diminished bladder capacity, upper tract changes, and relatively quick progression to urinary diversion. Larger prospective cohort studies are required to further characterize this severe phenotype of chronic noninfectious cystitis, aid earlier diagnosis, and guide management decisions.
Solutions for zero‐sum two‐player games with noncompact decision sets and unbounded payoffs
Authors: Feinberg Eugene A. , Kasyanov Pavlo O. , Zgurovsky Michael Z. 
Published: May 2023

AbstractThis article provides sufficient conditions for the existence of solutions for two‐person zero‐sum games with inf/sup‐compact payoff functions and with possibly noncompact decision sets for both players. Payoff functions may be unbounded, and we do not assume any convexity/concavity‐type conditions. For such games expected payoff may not exist for some pairs of strategies. The results of this article imply several classic facts. The article also provides sufficient conditions for the existence of a value and solutions for each player. The results of this article are illustrated with the number guessing game.
Azithromycin Mechanisms of Action in CRS Include Epithelial Barrier Restoration and Type 1 Inflammation Reduction
Authors: Renteria Axel E. , Valera Fabiana C.P. , Maniakas Anastasios , Adam Damien , Filali‐Mouhim Ali , Ruffin Manon , Mfuna Leandra Endam , Brochiero Emmanuelle , Desrosiers Martin Y. 
Published: May 2023

AbstractObjectivePrevious in vitro transcriptomic profiling suggests azithromycin exerts its effects in patients with chronic rhinosinusitis (CRS) via modulation of type 1 inflammation and restoration of epithelial barrier function. We wished to verify these postulated effects using in vitro models of epithelial repair and in vivo transcriptional profiling.Study DesignFunctional effects of azithromycin in CRS were verified using in vitro models of wounding. The mechanism of the effect of azithromycin was assessed in vivo using transcriptomic profiling.SettingAcademic medical center.MethodsEffects of azithromycin on the speed of epithelial repair were verified in a wounding model using primary nasal epithelial cells (pNEC) from CRS patients. Nasal brushings collected pre‐and posttreatment during a placebo‐controlled trial of azithromycin for CRS patients unresponsive to surgery underwent transcriptomic profiling to identify implicated pathways.ResultsAdministration of azithromycin improved the wound healing rates in CRS pNECs and prevented the negative effect ofStaphylococcus aureuson epithelial repair. In vivo, response to azithromycin was associated with downregulation in pathways of type 1 inflammation, and upregulation of pathways implicated in the restoration of the cell cycle.ConclusionRestoration of healthy epithelial function may represent a major mode of action of azithromycin in CRS. In vitro models show enhanced epithelial repair, while in vivo transcriptomics shows downregulation of pathways type 1 inflammation accompanied by upregulation of DNA repair and cell‐cycle pathways. The maximal effect in patients with high levels of type 1‐enhanced inflammation suggests that azithromycin may represent a novel therapeutic option for surgery‐unresponsive CRS patients.
Mass spectrometry‐based extracellular vesicle micromolecule detection in cancer biomarker discovery: An overview of metabolomics and lipidomics
Authors: Bai Liyi , Bu Fanqin , Li Xiangji , Zhang Shutian , Min Li 
Published: May 2023

AbstractExtracellular vesicles (EVs) become one of the most important sources of cancer biomarkers during the past decade due to their wide distribution in body fluids and physiological stability. Previous studies mainly focused on nucleic acids and proteins, while lipids and metabolites were largely neglected. Noticeably, many of those micromolecules exhibited a high abundance in EVs. Revealing the metabolomics and lipidomics of EVs would provide more comprehensive information for biomarker discovery. With the rapid development of mass spectrometry (MS) facilities, MS‐based micromolecule detection has become an emerging technique for EVs studies. Increasing evidence demonstrated the presence of EV‐associated metabolites and lipids in different types of samples (e.g., cell, urine, serum, stool), which exhibited promising performance in cancer diagnosis, prognosis, and prediction of treatment responses. This review aims to summarize advances in micromolecule profiling of EVs for cancer biomarker discovery, with an emphasis on MS‐based metabolomic and lipidomic analytical techniques. Challenges in this field, including the minimum sample quantity, normalization methods, and compound identifications, are also discussed along with possible solutions.
Cutaneous neutrophilic panniculitis and vasculitis in a shar‐pei with autoinflammatory disease
Authors: Cabré Maria , Ordeix Laura , Ferrer Lluís 
Published: May 2023

AbstractAn 8‐year‐old, spayed, female shar‐pei with an earlier clinical diagnosis of shar‐pei autoinflammatory disease presented with fever and plaque‐nodular ulcerative dermatitis. Dermatopathological examination was compatible with diffuse, non‐septal, neutrophilic panniculitis and leukocytoclastic vasculitis, and bacterial culture was negative. Good response to prednisone treatment was seen. Based on this case, cutaneous sterile neutrophilic panniculitis and leukocytoclastic vasculitis may be associated with shar‐pei autoinflammatory disease.
Most modifiable risk factors for hamstring muscle injury in women’s elite football are extrinsic and associated with the club, the team, and the coaching staff and not the players themselves: the UEFA Women’s Elite Club Injury Study
Authors: Ekstrand Jan , Hallén Anna , Marin Vittoria , Gauffin Håkan 
Published: May 2023

Abstract
Purpose
To describe the perceived importance of suggested hamstring injury risk factors according to chief medical officers (CMOs) of European women’s professional football clubs. A secondary objective was to compare if these perceptions differed between teams with a lower-than-average and higher-than-average hamstring injury burden.

Methods
The CMOs of eleven European professional women’s football clubs were initially asked to suggest modifiable risk factors for hamstring injury. These risk factors were rated in according with their perceived importance on a 5-graded Likert scale. Participating teams were divided in two groups depending on their hamstring injury burden during the 2020/21 season. The LOW group consisted of six teams that had a lower-than-average hamstring injury burden. The HIGH group consisted of five teams that had a higher-than-average hamstring injury burden.

Results
Twenty-one risk factors were suggested, most of which were extrinsic in nature, hence associated with the coaching staff, the team or the club organization rather than with the players themselves. The risk factors with the highest average importance were: “lack of communication between medical staff and coaching staff” and “load on players” (each with a weighted average of 3.9), followed by “lack of regular exposure to high-speed football actions during training” and “playing matches 2–3 times a week” (weighted average of 3.8 and 3.7). Differently from the LOW group, the HIGH group perceived the coaching factors (style of coach leadership, training/exercise surveillance by coaching staff) as more important.

Conclusion
In accordance to the eleven CMOs recruited in this study, most risk factors for hamstring injuries are extrinsic in nature and associated with the club, the team, and the coaching staff, and not the players themselves.

Level of evidence
Level III.
Deep learning segmentation results in precise delineation of the putamen in multiple system atrophy
Authors: Rau Alexander , Schröter Nils , Rijntjes Michel , Bamberg Fabian , Jost Wolfgang H. , Zaitsev Maxim , Weiller Cornelius , Rau Stephan , Urbach Horst , Reisert Marco , Russe Maximilian F. 
Published: May 2023

Abstract
Objectives
The precise segmentation of atrophic structures remains challenging in neurodegenerative diseases. We determined the performance of a Deep Neural Patchwork (DNP) in comparison to established segmentation algorithms regarding the ability to delineate the putamen in multiple system atrophy (MSA), Parkinson’s disease (PD), and healthy controls.

Methods
We retrospectively included patients with MSA and PD as well as healthy controls. A DNP was trained on manual segmentations of the putamen as ground truth. For this, the cohort was randomly split into a training (N = 131) and test set (N = 120). The DNP’s performance was compared with putaminal segmentations as derived by Automatic Anatomic Labelling, Freesurfer and Fastsurfer. For validation, we assessed the diagnostic accuracy of the resulting segmentations in the delineation of MSA vs. PD and healthy controls.

Results
A total of 251 subjects (61 patients with MSA, 158 patients with PD, and 32 healthy controls; mean age of 61.5 ± 8.8 years) were included. Compared to the dice-coefficient of the DNP (0.96), we noted significantly weaker performance for AAL3 (0.72; p < .001), Freesurfer (0.82; p < .001), and Fastsurfer (0.84, p < .001). This was corroborated by the superior diagnostic performance of MSA vs. PD and HC of the DNP (AUC 0.93) versus the AUC of 0.88 for AAL3 (p = 0.02), 0.86 for Freesurfer (p = 0.048), and 0.85 for Fastsurfer (p = 0.04).

Conclusion
By utilization of a DNP, accurate segmentations of the putamen can be obtained even if substantial atrophy is present. This allows for more precise extraction of imaging parameters or shape features from the putamen in relevant patient cohorts.

Clinical relevance statement
Deep learning-based segmentation of the putamen was superior to currently available algorithms and is beneficial for the diagnosis of multiple system atrophy.

Key Points
• A Deep Neural Patchwork precisely delineates the putamen and performs equal to human labeling in multiple system atrophy, even when pronounced putaminal volume loss is present.
• The Deep Neural Patchwork–based segmentation was more capable to differentiate between multiple system atrophy and Parkinson’s disease than the AAL3 atlas, Freesurfer, or Fastsurfer.