bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive discovery and functional characterization of the noncanonical proteome
Authors: Shi Chengyu , Liu Fangzhou , Su Xinwan , Yang Zuozhen , Wang Ying , Xie Shanshan , Xie Shaofang , Sun Qiang , Chen Yu , Sang Lingjie , Tan Manman , Zhu Linyu , Lei Kai , Li Junhong , Yang Jiecheng , Gao Zerui , Yu Meng , Wang Xinyi , Wang Junfeng , Chen Jing , Zhuo Wei , Fang Zhaoyuan , Liu Jian , Yan Qingfeng , Neculai Dante , Sun Qiming , Shao Jianzhong , Lin Weiqiang , Liu Wei , Chen Jian , Wang Liangjing , Liu Yang , Li Xu , Zhou Tianhua , Lin Aifu 
Published: January 2025

AbstractThe systematic identification and functional characterization of noncanonical translation products, such as novel peptides, will facilitate the understanding of the human genome and provide new insights into cell biology. Here, we constructed a high-coverage peptide sequencing reference library with 11,668,944 open reading frames and employed an ultrafiltration tandem mass spectrometry assay to identify novel peptides. Through these methods, we discovered 8945 previously unannotated peptides from normal gastric tissues, gastric cancer tissues and cell lines, nearly half of which were derived from noncoding RNAs. Moreover, our CRISPR screening revealed that 1161 peptides are involved in tumor cell proliferation. The presence and physiological function of a subset of these peptides, selected based on screening scores, amino acid length, and various indicators, were verified through Flag-knockin and multiple other methods. To further characterize the potential regulatory mechanisms involved, we constructed a framework based on artificial intelligence structure prediction and peptide‒protein interaction network analysis for the top 100 candidates and revealed that these cancer-related peptides have diverse subcellular locations and participate in organelle-specific processes. Further investigation verified the interacting partners of pep1-nc-OLMALINC, pep5-nc-TRHDE-AS1, pep-nc-ZNF436-AS1 and pep2-nc-AC027045.3, and the functions of these peptides in mitochondrial complex assembly, energy metabolism, and cholesterol metabolism, respectively. We showed that pep5-nc-TRHDE-AS1 and pep2-nc-AC027045.3 had substantial impacts on tumor growth in xenograft models. Furthermore, the dysregulation of these four peptides is closely correlated with clinical prognosis. Taken together, our study provides a comprehensive characterization of the noncanonical proteome, and highlights critical roles of these previously unannotated peptides in cancer biology.
Asymmetric ion transport through heterogeneous bilayers of covalent organic frameworks
Authors: Zhang Xiaopeng , Xin Shixian , Qian Qin , Xi Xiaoyi , Fang Munan , Sun Zhifei , Wang Yunyang , Li Yulong , Wang Yue , Tian Xingtao , Li Yuntong , Wang Siyu , Yang Jinlei , Tang Zhiyong , Li Lianshan 
Published: January 2025

AbstractIn recent years, with the development of interfacial polymerization methodologies, the successful preparation of covalent organic framework (COF) monolayers featuring ultrahigh pore density and molecule-scale thickness has become a reality. This advancement has enabled ion transport with ultrahigh flux across extremely short paths. Owing to these processes, the COF monolayers have shown wide potential applications ranging from energy conversion and artificial mechanosensing to ion sieving. To date, nanofluidic systems based on COF monolayers are homogeneous, leading to nearly symmetric ion transport properties. Studies on the ionic transport behavior within ultrathin COF heterojunctions are limited and remain challenging. Herein, using a two-step sequential self-assembly and subsequent interfacial polymerization strategy, bi-layered heterogeneous tetraphenylporphyrin-based COF membranes composed of negatively charged and positively charged monolayers were prepared. Using an electric field as a driving force, rectified ion transport was observed for the first time. Notably, this ionic current rectification property could be modulated by the salt concentration and the structural composition of the membrane, and it was universal for various COF heterojunctions with different chemical ingredients. These findings are beneficial for promoting the development of innovative nanofluidic materials and devices.
Ecological dynamics of Enterobacteriaceae in the human gut microbiome across global populations
Authors: Yin Qi , da Silva Ana C. , Zorrilla Francisco , Almeida Ana S. , Patil Kiran R. , Almeida Alexandre 
Published: January 2025

Abstract
Gut bacteria from the Enterobacteriaceae family are a major cause of opportunistic infections worldwide. Given their prevalence among healthy human gut microbiomes, interspecies interactions may play a role in modulating infection resistance. Here we uncover global ecological patterns linked to Enterobacteriaceae colonization and abundance by leveraging a large-scale dataset of 12,238 public human gut metagenomes spanning 45 countries. Machine learning analyses identified a robust gut microbiome signature associated with Enterobacteriaceae colonization status, consistent across health states and geographic locations. We classified 172 gut microbial species as co-colonizers and 135 as co-excluders, revealing a genus-wide signal of colonization resistance within Faecalibacterium and strain-specific co-colonization patterns of the underexplored Faecalimonas phoceensis. Co-exclusion is linked to functions involved in short-chain fatty acid production, iron metabolism and quorum sensing, while co-colonization is linked to greater functional diversity and metabolic resemblance to Enterobacteriaceae. Our work underscores the critical role of the intestinal environment in the colonization success of gut-associated opportunistic pathogens with implications for developing non-antibiotic therapeutic strategies.
Machine learning in the prediction of human wellbeing
Authors: Oparina Ekaterina , Kaiser Caspar , Gentile Niccolò , Tkatchenko Alexandre , Clark Andrew E. , De Neve Jan-Emmanuel , D’Ambrosio Conchita 
Published: January 2025

AbstractSubjective wellbeing data are increasingly used across the social sciences. Yet, despite the widespread use of such data, the predictive power of approaches commonly used to model wellbeing is only limited. In response, we here use tree-based Machine Learning (ML) algorithms to provide a better understanding of respondents’ self-reported wellbeing. We analyse representative samples of more than one million respondents from Germany, the UK, and the United States, using data from 2010 to 2018. We make three contributions. First, we show that ML algorithms can indeed yield better predictive performance than standard approaches, and establish an upper bound on the predictability of wellbeing scores with survey data. Second, we use ML to identify the key drivers of evaluative wellbeing. We show that the variables emphasised in the earlier intuition- and theory-based literature also appear in ML analyses. Third, we illustrate how ML can be used to make a judgement about functional forms, including the existence of satiation points in the effects of income and the U-shaped relationship between age and wellbeing.
Exploring the utility of unretouched lithic flakes as markers of cultural change
Authors: Will Manuel , Rathmann Hannes 
Published: January 2025

AbstractLithic artefacts provide the principal means to study cultural change in the deep human past. Tools and cores have been the focus of much prior research based on their perceived information content and cultural relevance. Unretouched flakes rarely attract comparable attention in archaeological studies, despite being the most abundant assemblage elements and featuring prominently in ethnographic and experimental work. Here, we examine the potential of flake morphology for tracing cultural change utilising 4,512 flakes, each characterised by 16 standard mixed-scale attributes, from a well-documented cultural sequence at the Middle Stone Age site of Sibhudu, South Africa. We quantified multivariate similarities among flakes using FLEXDIST, a highly versatile method capable of handling mixed, correlated, incomplete, and high-dimensional data. Our findings reveal a significant gradual change in flake morphology that aligns with the documented cultural succession at Sibhudu. Furthermore, our analysis provides new insights into the patterning of variability throughout the studied sequence. The demonstrated potential of flakes to track cultural change opens up additional avenues for comparative research due to their ubiquity, the availability of commonly recorded attributes, and especially in the absence of cores or tools. FLEXDIST, with its versatile applicability to complex lithic datasets, holds particular promise in this regard.
Decoupling of surface water storage from precipitation in global drylands due to anthropogenic activity
Authors: Zhao Gang , Gao Huilin , Li Yao , Tang Qiuhong , Woolway R. Iestyn , Merder Julian , Rosa Lorenzo , Michalak Anna M. 
Published: January 2025

Abstract
The availability of surface water in global drylands is essential for both human society and ecosystems. However, the long-term drivers of change in surface water storage, particularly those related to anthropogenic activities, remain unclear. Here we use multi-mission remote sensing data to construct monthly time series of water storage changes from 1985 to 2020 for 105,400 lakes and reservoirs in global drylands. An increase of 2.20 km3 per year in surface water storage is found primarily due to the construction of new reservoirs. For lakes and old reservoirs (constructed before 1983), conversely, the trend in storage is minor when aggregated globally, but they dominate surface water storage trends in 91% of individual global dryland basins. Further analysis reveals that long-term storage changes in these water bodies are primarily linked to anthropogenic factors—including human-induced warming and water-management practices—rather than to precipitation changes, as previously thought. These findings reveal a decoupling of surface water storage from precipitation in global drylands, raising concerns about societal and ecosystem sustainability.
Precision manufacturing of glass dielectric resonator antennas for sub‐THz applications using laser induced deep etching technology
Authors: Bekker Elizabeth , Yin Jiexi , Valenziano Luca , Lootze Michael , Schulz‐Ruhtenberg Malte , Zwick Thomas , Bhutani Akanksha 
Published: January 2025

AbstractThis letter demonstrates for the first time how laser induced deep etching (LIDE) technology is used to manufacture highly precise glass dielectric resonator antenna (DRA) for sub‐THz applications. The glass resonator antennas shown in this letter operate in the 110–170 GHz (D‐band) frequency range, which is highest frequency at which glass dielectric resonator antennas have been demonstrated to date. The letter discusses the design, manufacturing precision and measurement details for both a single rectangular DRA element, as well as a 4‐by‐4 array. The measured bandwidth of the singular rectangular DRA stretches from 117–160 GHz, with a peak gain of 6.1 dBi. The array, in turn, has a measured bandwidth of 135–146 GHz, with a peak gain of 13.2 dBi. The excellent measurement results are proof of the suitability of the LIDE technology for highly precise sub‐THz antennas.
The success of optical variability in uncovering active galactic nuclei in low stellar mass galaxies
Authors: Bernal S. , Sánchez-Sáez P. , Arévalo P. , Bauer F. E. , Lira P. , Sotomayor B. 
Published: January 2025

Context. The origins of supermassive black holes (SMBHs) at the centers of massive galaxies are a topic of intense investigation. One way to address this subject is to identify the seeds of SMBHs as intermediate-mass black holes (IMBHs; 100 M⊙ < MBH < 106 M⊙). IMBHs are expected to be found at the centers of low stellar mass galaxies (LSMGs).
Aims. Our goal is to complete the census of SMBHs in LSMGs. In this work our aim is to establish the purity of active galactic nucleus (AGN) selection by algorithms based on optical variability and to characterize the black hole population found through this method.
Methods. We used random forest algorithms to classify all objects in a large portion of the sky, using optical light curves obtained from, or built from images provided by, the Zwicky Transient Facility (ZTF). We compared different selection sets based on alerts (flux changes with at least 5σ significance) or complete light curves derived from different photometric selection algorithms. The AGN candidates thus selected were cross-matched with objects in the NASA-Sloan Atlas (NSA) of local galaxies, with M* < 2 × 1010 M⊙. The AGN nature of these candidates was verified and characterized using archival optical spectra from SDSS. We further established the fraction of candidates with counterparts in the eROSITA Data Release 1 catalog of X-ray sources.
Results. From an initial sample of 506 candidates, 415 have good-quality spectra. Among these 415 objects we found significant broad Balmer lines in the spectra for 86% (357) of the candidates. When considering BPT classifications, five additional candidates were confirmed, resulting in 87% (362) confirmed candidates. Specifically, broad Balmer lines were detected in 94%–98% of the AGN candidates selected from complete light curves and in 80% of those selected from the less frequent ZTF alerts. The black hole masses estimated from the spectra range from 2.2 × 106 M⊙ to 4.2 × 107 M⊙, reaching lower values for the candidates selected using the more sensitive light curves. The black hole masses obtained cluster around 0.1% of the stellar mass of the host from the NSA catalog. Two-thirds of the AGN candidates are classified as Seyfert or composite by their narrow emission line ratios (BPT diagnostics), while the rest are star-forming. Almost all the candidates classified as Seyfert and over 50% of those classified as star-forming have significant broad emission lines (BELs). We found X-ray counterparts for 67% of the candidates that fall in the footprint of the eROSITA-DE DR1. Considering only the candidates with significant BELs, the matches increase to 75%, regardless of where they appear in the BPT diagnostics diagrams.
Spectral and photometric characterization of (98943) Torifune in preparation for the Hayabusa2# spacecraft flyby
Authors: Bourdelle de Micas J. , Perna D. , Fornasier S. , Dotto E. , Ieva S. , Barucci M. A. , Geem J. , Hasegawa S. , Ishiguro M. , Kitazato K. , Kuroda D. , Mazzotta Epifani E. , Palomba E. , Yoshikawa M. , Hirabayashi M. 
Published: January 2025

Context. After a successful sample-return mission to the asteroid (162173) Ryugu, the Hayabusa2 spacecraft is currently on its way to encounter two near-Earth asteroids: (98943) Torifune (formerly known as 2001 CC21) and 1998 KY26.
Aims. In this article, we study the asteroid (98943) Torifune, the first object that is to be visited by the spacecraft during its extended mission. To prepare for its encounter with the spacecraft, it is crucial to study this object from Earth. We conducted several ground-based observations to characterize this asteroid and understand its mineralogy.
Methods. In January and February 2023, we carried out spectroscopic and photometric observations at the 2.56 m Nordic Optical Telescope, in the visible and near-infrared ranges, covering different rotational phases of the asteroid.
Results. Based on spectra analysis in the visible and near-infrared ranges, confirmed by the color studies, we determined that Torifune belongs to the Sq-type, according the Bus-DeMeo taxonomy. Assuming this taxonomy and its equivalent diameter (D ∼ 465 ± 15 m), we estimated the mass of this asteroid to be 1.81 ± 0.11  ×  1011 kg. In term of mineralogy, we found a close match with ordinary L chondrites.
Conclusions. As our observations covered almost a complete rotation phase, we did not find any spectral variation at different rotational phases, meaning that there is no substantial heterogeneities on Torifune’s surface. We compared the spectral slope of (98943) Torifune with that of the S-complex members of the Lucienne family. However, further studies, especially dynamical ones, are needed to confirm whether this object originates from the Lucienne family.
Anisotropic tidal dissipation in misaligned planetary systems
Authors: Auclair-Desrotour Pierre , Boué Gwenaël , Loire Baptiste 
Published: January 2025

Context. Tides are the main driving force behind the long-term evolution of planetary systems. The associated energy dissipation and momentum exchanges are commonly described by Love numbers, which relate the exciting potential to the tidally perturbed potential. These transfer functions are generally assumed to depend solely on tidal frequency and body rheology, following the isotropic assumption, which presumes invariance of properties by rotation about the centre of mass.
Aims. We examine the limitations of the isotropic assumption for fluid bodies, in which Coriolis acceleration breaks spherical symmetry, resulting in rotational scattering and complex tidal responses.
Methods. Using angular momentum theory, we derived a new formalism to calculate the tidal rates of energy and momentum transfers in non-isotropic cases. We applied this formalism to the Earth-Moon system to assess the effects of anisotropy in planet-satellite systems with misaligned spin and orbital angular momenta.
Results. Our findings indicate that the isotropic assumption can introduce significant errors in planetary evolution models, particularly in the dynamical tide regime. These errors stem from forced wave resonances, with inaccuracies in energy dissipation scaling in proportion to resonance amplification factors.
Supramolecular Chemistry: An Enabling Tool for Asymmetric Catalysis
Authors: Cunningham Laura 
Published: January 2025

AbstractAsymmetric synthesis and supramolecular chemistry are cornerstones of modern organic chemistry. The combination of both fields to develop new approaches to enantioselective catalysis has gained considerable momentum in recent years. Herein, we highlight some of the advantages offered by various supramolecular architectures over conventional chiral catalysts and reflect on obstacles that currently limit widespread use of supramolecular tools in asymmetric synthesis.1	Introduction2	Discussion2.1	Macrocycles2.2	Surfactants2.3	Metal-Organic Cages and Frameworks2.4	Covalent Organic Frameworks2.5	DNA2.6	Mechanically Interlocked Molecules3	Summary and Outlook
Asymptomatic and Unnoticed Intra-articular Screw Over 18 Years after Fracture of the Posterior Wall of the Acetabulum – A Question of Stability?
Authors: Audretsch Christof K. , Schmidutz Florian , Küper Markus Alexander 
Published: January 2025

AbstractFractures of the posterior wall of the acetabulum occur in a frequency of 25–30%. Multifragmentary fractures involving 40–50% of the acetabular surface, the quality of reduction as well as involvement of cartilage and acetabular labrum are considered to have an impact on the development of a reduced posterior stability of the hip joint. This results in a shift of the main weight bearing area with development of a posttraumatic osteoarthritis. In the presented case, a 42-year old male patient was operated on 18 years ago due to a posterior acetabular wall fracture. Retrospectively, one of the screws was located partially intraarticular. However, the patient was asymptomatic over the 18-year period. The first consultation was due to unspecific symptoms of osteoarthritis of the right hip joint especially during flexion and external rotation. Due to only mild radiological signs of osteoarthritis, we indicated only the removal of the intraarticular screw. The symptoms postoperatively switched to a feeling of instability, so a total hip arthroplasty was performed. Since the operation, the patient is asymptomatic regarding the hip joint. The intraarticular screw seemed to stabilize the hip joint. This case demonstrates the importance of a good posterior guidance for the stability of the hip joint on one hand. On the other hand, it demonstrates the minor stress load of the posterior acetabular region, especially after fracture of the posterior wall. Therefore, a good posterior guidance should be one major aim of treatment of posterior acetabular wall fractures.
Dams, development and disposability: Eco-anxiety, precarity and submerging voices in Na. D’souza’s Dweepa
Authors: Karmakar Goutam 
Published: January 2025

AbstractThe construction of large dams in India has faced criticism for its neo-colonial and capitalist practices. This highlights the importance of accountability, the consequences of development discourse, and the tangible impacts on the lives of those affected by dams, development initiatives, displacement, and denial of compensation. The pursuit of large-scale construction projects frequently promotes a conspicuous consumerist perspective, disregarding both marginalised groups and the ethics of sustainable development. The absence of ethical considerations such as empathy, inclusion, and egalitarian ideology in the development narrative often leads to the devaluation of certain lives while prioritising the safety and security of others. Within this particular setting, it is important to recognise the trajectories of those whose lives are considered disposable. In this context, the article scrutinizes Na. D’souza’s novella Dweepa, delving into the experiences of individuals who have faced eco-anxiety, precariousness, and vulnerability, ultimately culminating in their tragic demise due to the construction of the Linganamakki dam over the Sharavathi river.
What can emotion and abstract words tell us about context availability ratings?
Authors: Mason Catherine Jane , Hameau Solène , Nickels Lyndsey 
Published: January 2025

Abstract
Semantic dimensions such as context availability, imageability and valence, form core components of many
theoretical accounts of lexical processing. Typically, normative data for such semantic dimensions are drawn from subjective
ratings, however, questions have been raised regarding the reliability and validity of these ratings. In this paper, we discuss
this issue with a focus on context availability norms. Using data collected for another study, we show that context availability
ratings required significantly higher rates of data exclusions at the level of both participants and items compared to other
variables. In addition, high standard deviations at the item level, indicated a substantial degree of disagreement between
participants. This suggested that some participants may have had difficulty understanding the concept of context availability
which hindered their ability to complete the ratings. We provide recommendations for future research focusing on context
availability and for norm collection procedures more broadly in order that the validity of such norms can be improved. In
particular, we suggest that clear guidelines are required for data cleaning in order that the reliability of such norms is
maximised and to facilitate replication across studies.
Gaussian orbital perturbation theory in Schwarzschild space-time in terms of elliptic functions
Authors: Yanchyshen Oleksii , Lämmerzahl Claus 
Published: January 2025

Abstract
General relativistic Gauss equations for osculating elements for bound orbits under the influence of a perturbing force in an underlying Schwarzschild space-time have been derived in terms of Weierstrass elliptic functions. Thereby, the perturbation forces are restricted to act within the orbital plane only. These equations are analytically solved in linear approximation for several different perturbations such as cosmological constant perturbation, quantum correction to the Schwarzschild metric, and hybrid Schwarzschild/post-Newtonian 2.5 order self-force for binary systems in an effective one-body framework.