bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methotrexate induced erythema multiforme: a rare case report
Authors: Hasan Md Mehedi , Khalil Muhammad Ibrahim , Haque Mirza Shariful , Rahman Md Raziur , Yesmin Sabrina 
Published: January 2023

Methotrexate is commonly used in the treatment of inflammatory disorders and malignancies. Although it is an effective therapeutic agent, it may have serious adverse effects in both therapeutic dose and overdose. Here, we report a case of a 54-year-old lady with polyarthritis, who was prescribed 2 tablets of methotrexate (10 mg) orally once a week. However, mistakenly the patient started taking the drug daily. After 12 days of starting methotrexate, she presented with widespread skin lesions, sore mouth and dysphagia. A diagnosis of methotrexate induced erythema multiforme was made. Laboratory investigations revealed pancytopenia. She was managed conservatively. Although rare, methotrexate overdose should be considered along with other possibilities in a patient with erythema multiforme. This case report also focuses on the rational use of drugs as well as the importance of good communication between health care professionals and patients.
BIRDEM Med J 2023; 13(1): 52-55
Avaliação do potencial de geração de energia a partir de resíduos orgânicos de um restaurante popular
Authors: Rocha Mayesk Alves , Oliveira Junior Antonio Martins de , Abud Ana Karla de Souza 
Published: January 2023

A urgência de inovação no âmbito energético, aliada à preocupação ambiental e à alta geração de resíduos no cenário mundial, impulsiona cada vez mais o uso de técnicas de digestão anaeróbia como tecnologia próspera para tratamento de tais passivos ambientais e a produção do biogás. Desta forma, a utilização de biodigestor para produção de biogás é uma das possíveis maneiras de aproveitar o potencial energético renovável disponível no meio ambiente. Com isso, a presente pesquisa tem o objetivo de avaliar o potencial de produção de biogás na operação de biodigestor de bancada em batelada, a partir dos resíduos produzido em restaurante popular localizado no bairro de Rosa Elze, na cidade de São Cristóvão, utilizando como inóculo esterco de caprinos, em concentração adversa (0, 1, 2 e 3%). Os biodigestores utilizados no estudo foram desenvolvidos a partir a reutilização de garrafas de polietileno tereftalato (PET) e operados por 21 dias à temperatura de 25 °C. Com isso, foi possível verificar a evolução da geração diária de biogás por meio da decomposição anaeróbia de matéria orgânica e, também, acompanhar a temperatura e o pH das amostras. De acordo com os resultados encontrados nesta pesquisa, a melhor condição para a produção do biogás se deu com o a concentração de 3% de inóculo, com pH de 7,12, ou seja, com ajuste de pH, obtendo-se uma produção de 18 mL de biogás. No potencial de geração de energia, o presente trabalho obteve uma geração de 321 kWh/ mês, indicando um ganho de R$157,97/ mês com o biogás produzido pelos resíduos alimentares do restaurante popular. Indicam a digestão anaeróbica como processo sustentável, sendo eficiente e com baixo custo.
Análise do Traçado Geométrico e Desempenho de Segurança do Trecho Curvo Localizado no Km 448 da Rodovia BR – 101
Authors: Teixeira Niel Nascimento , Jesus Diana Santos de , Vieira João Ribeiro Santana 
Published: January 2023

Diante do elevado índice de acidentes ocorridos no trecho curvo localizado na rodovia BR 101, Km 448 - Bahia, conhecida popularmente como a “curva do padre”, o presente estudo realizou um diagnóstico das características geométricas através do software AutoCad Civil 3D e verificou o desempenho de segurança do segmento, a partir da análise dos dados dos acidentes de trânsito, dos últimos seis anos, ocorridos nesta curva situada na cidade de Aurelino Leal. Por meio dos resultados obtidos, pôde-se concluir que o trecho se trata de um segmento crítico, e que, foram encontradas elevadas inconsistências na geometria (na superelevação, na largura da pista, na rampa máxima e na distância de visibilidade de parada) do trecho da rodovia federal, que combinadas, estavam diretamente relacionadas ao seu baixo desempenho em segurança.
Fissuras Labiopalatinas: levantamento epidemiológico dos pacientes de um centro especializado de Belo Horizonte - MG
Authors: Silva Victoria Scárdua Medeiros , Silva Juliana Fátima Oliveira , Fernandes Sabrina Oara Freire , Franco Amanda Gonçalves , Pires Regina Coeli Cançado Peixoto 
Published: January 2023

As fissuras labiopalatais (FLP) são consideradas um problema de saúde pública e uma das mais comuns mal formações congênitas faciais. Apresentam-se como uma das mais frequentes anomalias craniofaciais no Brasil, com uma prevalência de 1 a cada 1.000 nascidos vivos no país. A síndrome causa defeitos congênitos em lábio e/ou palato, sendo causada pela ausência de fusão dos processos palatinos durante o período gestacional. O objeto deste estudo foi realizar um levantamento epidemiológico dos pacientes atendidos no Hospital da Baleia / Fundação Benjamin Guimarães em Belo Horizonte - MG. Os dados foram coletados a partir dos prontuários dos pacientes atendidos no período de 2018 a 2022, e foram tabulados em uma planilha do Excel e analisados utilizando-se as ferramentas estatísticas do software SPSS for Windows® versão 20.0. Foram geradas tabelas de frequência e análise descritiva, da amostra total de 943 prontuários, 165 foram excluídos por não apresentarem anomalias congênitas, resultando em um total de 778 casos para análise. Em relação ao tipo de fissura, a mais prevalente foi a pós-forame incisivo com um total de 245 (31,5%) casos, o gênero predominante foi o masculino com 442 (56,9%) casos, a região de procedência mais frequentemente encontrada foi a de demais localidades e estados com 437 (56,1%) casos, por último a faixa etária mais prevalente foi a de 0 - 11 meses com total de 485 (62,3%) casos. O conhecimento desses dados é muito importante, pois poderá subsidiar informações para novas pesquisas e auxiliar no planejamento dos serviços.
Impact of Therapeutics on Unified Immunity During Allergic Asthma and Respiratory Infections
Authors: Flores-Torres Armando S. , Samarasinghe Amali E. 
Published: January 2023

Graphical AbstractInterplay between infectious agents and allergic milieu. Respiratory infections caused by viruses, bacteria and fungi play an important role in asthma pathogenesis. The immune milieu in allergic asthma may be both defective and protective during respiratory infections. Some bacteria are linked to steroid-resistant neutrophilic asthma and an aberrant immune response. Thermotolerant fungi generally induces a T2 immune response in asthma and are linked to asthma severity and higher corticosteroid requirement. Steroid-resistant neutrophilic asthma is associated with increased airway bacterial burden and reduced bacterial diversity. Corticosteroids and antibiotics induce dysbiosis in asthmatics, which may cause immune system alterations. Biologics and antivirals may be beneficial in some patients. However, the effect of eosinophil depletion on antiviral immunity in asthmatics remains unknown. Influenza and COVID-19 vaccination are recommended in asthmatics, but pneumococcal vaccine benefits are still under debate.
Reducing Organic Load From Industrial Residual Process Brine With a Novel Halophilic Mixed Culture: Scale-Up and Long-Term Piloting of an Integrated Bioprocess
Authors: Mainka Thomas , Herwig Christoph , Pflügl Stefan 
Published: January 2023

Integrating bioprocess solutions for treatment and subsequent reuse of saline residual process brine into industrial processes could increase the sustainability of production chains. However, such bioprocesses require large-scales and a robust operation over a prolonged period. Consequently, the aim of this study was to analyze scale-up equivalence as well as continuous and stable process performance of a previously established lab scale process for the degradation of organic contaminants (formate and aromatic compounds) in an industrial context. To that end, a pilot-scale bubble column bioreactor system equipped with a membrane-based cell retention system for process intensification was integrated at an industrial production site. The process was successfully scaled-up and continuously operated for more than 210 days. Overall, the process proved to be robust towards changing compositions of the residual process brine stream and degradation rates for organic contaminants were close to 100%. Interestingly, due to the unsterile process conditions, the original Haloferax mediterranei culture was replaced by a novel halophilic bacterial community consisting of three bacterial genera. To further improve process economics and productivity, an optimization of the co-substrate feeding strategy for glycerol is required, as results indicated a potential correlation between glycerol feeding and formate degradation rates. To that end, decoupling of the glycerol feeding from the residual process brine feed is a potential way to increase process control options and allow for easy adaptation of the process to changing residual process brine compositions. Ultimately, the process described here could be a promising alternative for chemical or physical methods of treating residual process brine and once more underlines the potential to exploit natural microbial diversity for industrial purposes.
Product selectivity and mass transport in levulinic acid transfer hydrogenation by monolithic MIL-100, MIL-88B and ZIF-8@Pd MOFs
Authors: McIntyre Sean R. , Saenz-Cavazos Paola A. , Hunter-Sellars Elwin , Williams Daryl R. 
Published: January 2023

The diffusion processes between adsorbent and adsorbate naturally play a significant role in the efficiency and selectivity of the heterogenous catalytic process. This paper considers the importance of diffusion processes in the transfer hydrogenation reaction of levulinic acid to γ-valerolactone by MIL-88B, MIL-100, and ZIF8@Pd monolithic catalysts. Over a period of five catalytic cycles, it was shown that the Fe-based catalysts can achieve similar conversions to the ZIF-8 supported Pd, with the only current limitation being the lower aqueous stability of these MOFs. Diffusion constants were calculated using the ZLC method, with micropore diffusion limitation found for ZIF-8 and MIL-100 monolithic frameworks at 2.7 x 10−8 and 4.6 x 10−8 cm2 s−1 respectively. This diffusion limitation was also confirmed by IR spectroscopy with an increasing concentration of C—H bands on the MOF substrate post-reaction. Mass transfer coefficients, also calculated by ZLC, revealed increased mass transport for the hydrophobic ZIF-8 framework, which perhaps aids in the γ-valerolactone selectivity over side products that are produced in the absence of catalytic material, as seen for MIL-88B and MIL-100 after multiple uses.
Differentially culturable tubercle bacteria as a measure of tuberculosis treatment response
Authors: Peters Julian S. , McIvor Amanda , Papadopoulos Andrea O. , Masangana Tshepiso , Gordhan Bhavna G. , Waja Ziyaad , Otwombe Kennedy , Letutu Matebogo , Kamariza Mireille , Sterling Timothy R. , Bertozzi Carolyn R. , Martinson Neil A. , Kana Bavesh D. 
Published: January 2023

IntroductionRoutine efficacy assessments of new tuberculosis (TB) treatments include quantitative solid culture or routine liquid culture, which likely miss quantification of drug tolerant bacteria. To improve these assessments, comparative analyses using additional measures such as quantification of differentially culturable tubercle bacteria (DCTB) are required. Essential for enabling this is a comparative measure of TB treatment responses using routine solid and liquid culture with liquid limiting dilutions (LLDs) that detect DCTB in sputum.MethodsWe recruited treatment-naïve TB patients, with and without HIV-infection, and serially quantified their sputum for DCTB over the course of treatment. ResultsSerial sputum sampling in 73 individuals during their first 14 days of treatment demonstrated that clearance of DCTB was slower compared to routine solid culture. Treatment response appeared to be characterized by four patterns: (1) Classic bi-phasic bacterial clearance; (2) early non-responders with slower clearance; (3) paradoxical worsening with an increase in bacterial count upon treatment initiation; and (4) non-responders with no change in bacterial load. During treatment, LLDs displayed greater bacterial yield when compared with quantitative solid culture. Upon treatment completion, 74% [46/62] of specimens displayed residual DCTB and within this group, two recurrences were diagnosed. Residual DCTB upon treatment completion was associated with a higher proportion of MGIT culture, GeneXpert, and smear positivity at two months post treatment. No recurrences occurred in the group without residual DCTB.DiscussionThese data indicate that DCTB assays detect distinct subpopulations of organisms in sputum that are missed by routine solid and liquid culture, and offer important alternatives for efficacy assessments of new TB treatments. The residual DCTB observed upon treatment completion suggests that TB treatment does not always eliminate all bacterial populations, a finding that should be investigated in larger cohorts.
Fourier-transformed infrared spectroscopy study of the ancient ivory tusks from the Sanxingdui site
Authors: Li Xiaoguang , Wang Chong , Zhang Yu , Zhang Ruojing , Li Sifan , Xiao Qing , Su Wen 
Published: January 2023

The archeological site at Sanxingdui preserves a considerable amount of ancient ivory tusks in its artifact pits, and accurately and quantitatively analyzing the original chemical signatures of these ivory tusks is a critical step in interpreting their buried history. In this study, 123 unearthed ivory tusks were characterized using Fourier-transformed infrared spectroscopy (FTIR), and seven in situ heating experiments were conducted. The hydroxylapatite crystallinity and carbonate concentration were quantitatively determined in line with the absorbance peak intensities of the corresponding bands. The average values of splitting factor (SF), type B carbonate/type A carbonate ratio (BC/AC), carbonate/phosphate ratio (C/P), type B carbonate/phosphate ratio (BPI), type A carbonate/phosphate ratio (API), and water–amide on the phosphate index (WAMPI) were calculated to be 3.84, 0.98, 0.12, 0.37, 0.38, and 0.11, respectively. The ratios of the 1,416 cm−1–1,454 cm−1 carbonate bands of the ivory tusks were used to quantitatively estimate the different types of carbonate content in the ivory tusks. Heating experiments were designed to simulate the effect of heat on the hydroxylapatite structures. We suggest that the SF and the C/P indices can serve as distinctive preservation indices of ancient ivory tusks as well as the BC/AC index and hydroxyl types.
Imaging the subducting slab and mantle upwelling under the Japan islands revealed by double-difference tomography
Authors: Zhang Zhengshuai , Zheng Jianchang , Wang Shuhao , Li Cuiqin , Liu Fangbin 
Published: January 2023

In this paper, we collected the seismic phase arrival data of 14,033 local natural earthquakes above magnitude 3.0 recorded by 435 seismograph stations in the study area provided by the International Seismological Centre (ISC), covering the period from January 2011 to April 2020. We selected the first arrival P- and S-wave arrival time data and obtained 281,859 P- and 112,926 S-wave absolute arrival times and 528,250 P-differential and 207,968 S-differential arrival times. Then we determined 3-D P and S wave velocity structures from the Japan Trench to the back arc area under the Japan Islands by using double-difference tomography method. The results show strong lateral heterogeneities under the forearc region. The subducting Pacific slab is imaged clearly as a high-velocity (high-V) faster than the surrounding mantle. Low-velocity (low-V) zones are imaged in the mantle wedge with significant along arc variations under the volcanic front. The vertical section shows that the low velocity zone extends to a depth of approximately 70–150 km below the arc. The crust and mantle wedges beneath the front and back arcs of the volcanoes reveal a low-V anomaly, the likely main source of which is the partial melting of plate and mantle wedge material. Referring to the previous results of plate dehydration, mineral composition and thermal state, it is found that fluids play a crucial role in the arc magmatism and plate melting of mantle wedge behind Japan Trench. The fluids brought down by the Pacific subducting plate are released into the mantle wedge by dehydration and subsequently transported upward by the upwelling flow in the mantle wedge. The present results obtained using new and advanced imaging methods enrich the understanding of the velocity structure beneath Japan Islands, which may improve the understanding of the dynamic processes of subduction zones and mantle upwelling.
Quantification of rupture directivity effects on strong ground motion during the 8 January 2022 MS6.9 Menyuan earthquake in Qinghai, China
Authors: Xie Junju , Wang Wencai , An Zhao , Li Kewei , Tian Xiufeng , Wu Lina , Gao Shude , Zhang Weidong , Yuan Jie 
Published: January 2023

On 8 January 2022, an MS6.9 earthquake occurred in the Menyuan county, Qinghai province at the northeastern margin of the Tibetan Plateau. A dense observatory network consisting of accelerographs and intensity meters has obtained many acceleration recordings in this region, which previously had only a few strong motion recordings. Using acceleration data recorded by 141 accelerographs and micro-electro mechanical system (MEMS)-based intensity meters within 100 km of the causative fault, we investigated the spatial distribution and attenuation characteristics of the near-source ground motion during this event. The observed response spectra were compared with the prediction obtained using the NGA-West2 models. It was found that, in the long-period section of &gt;1.0 s, the acceleration response spectra in the rupture forward direction (southeast of the epicenter) were greater than the prediction, while observations on the northwest side were lower than the prediction. Through the spatial distribution of the ground motion and quantitative analysis of the residuals, we found that the rupture directivity effects on the ground motions were controlled by the spatial azimuth relative to the fault and the along-strike projected length of the rupture, which mainly affected the long-period portion of the &gt;1.0 s. In the rupture forward direction, the spectral accelerations (SAs) with periods of 1.0–10.0 s were enhanced to 1.18–1.56 times the average. In the backward direction (northwest of the epicenter), the SAs with periods of 1.0–10.0 s were only 0.63–0.86 times the average. The rupture directivity effects during the MS6.9 (MW6.6) earthquake exhibited an obvious period-dependence and narrowband characteristics, and the amplification effects were the strongest at 5.0 s. The amplification factors in the straight forward directions were underestimated by the empirical model. Two typical velocity pulse records were observed in the rupture forward direction, and their response spectra were significantly amplified at long periods of greater than 1.0 s, with peak amplification values of 4.0–6.0 near the characteristic period of the pulses. This amplification was related to the resonance excited by a specific periodic pulse. Our study provides a reference of quantifying near-source effects for both moderate and major shallow crustal earthquakes by using MEMS recordings in this region.
Study on the influence of industrial structure optimization on water environment and economy: A case study of Changzhou city
Authors: Bu Jiuhe , Zhang Shuiling , Wang Xuesong , Li Chunhui , Wang Xuan , Liu Qiang , Xu Xiangen , Wang Xia 
Published: January 2023

Economic development and large amounts of industrial production have led to environmental deterioration. The assessment and prediction of water environment capacity (WEC) are crucial supports for water quality target management. Therefore, this study aims to improve WEC via changes in the industrial structure and to analyze the economic changes. For this purpose, the economic efficiency (EE), water use efficiency (WUE), and water treatment efficiency (WTE) are estimated by the EE–SBM (slack-based measure)–DEA (data envelopment analysis) model. Based on the proposed model, the industry is divided into three types: green enterprises, yellow enterprises, and red enterprises. Yellow enterprises and red enterprises are the major supervision subjects, and the spatial distribution of different environmental risks is identified. The WECs of the main canals are analyzed based on dynamic changes in the industrial structure by integrating the 0-D and MIKE11 models. The results showed that after adjusting the industrial structure, the maximum added values of the WEC of chemical oxygen demand (COD), total nitrogen (TN), ammonia nitrogen (NH3–N), and total phosphorus (TP) are 1,744.66 t/a, 536.14 t/a, 24.81 t/a, and 4.16 t/a, respectively. The results show that the canals (R40, R41, R20, R19, and R17) are overloaded with pollutants and indicate that TN is included as a water environment quality assessment target. Furthermore, after the optimization of the industrial structure, the loss of industrial output value is 174.44 million yuan, and the added value of the environmental economy is 232.12 million yuan. The findings provide important technical support for achieving industrial upgrading and sustainable development.
Gains and challenges with the Classroom Assessment Scoring System in a social pedagogical tradition
Authors: Evertsen Cecilie , Størksen Ingunn , Tharaldsen Kjersti Balle , Kucirkova Natalia 
Published: January 2023

IntroductionThis qualitative study explores how Early Childhood Education and Care (ECEC) professionals’ perceptions of gains and challenges using the Classroom Assessment Scoring System (CLASS, Pre-K and Toddler) within the social pedagogical tradition in Norwegian ECEC.MethodsFocus group interviews (n = 22), group interviews (n = 4), and in-depth interviews (n = 3) were conducted online, followed by conventional content analysis.ResultsThe findings indicate that ECEC professionals perceived CLASS as contributing to their pedagogical understanding and practice. At the same time, the introduction of CLASS enhanced ECEC professionals’ awareness regarding the pedagogical value of the social pedagogical tradition (SPT), which they wished to preserve and protect, and the specific elements of the school readiness tradition (SRT), which they wished to include in their pedagogical understanding of high-quality ECEC pedagogy.DiscussionThe findings suggest that the use of CLASS expands ECEC professionals’ understanding of the value of both pedagogical traditions. Finally, inspired by the present study’s findings regarding interaction quality, the research team proposes a hybrid model of pedagogical approaches in ECEC.