bluuebunny/crossref_metadata_2025_split huggingface dataset:
The inspiratory activity of respiratory center and respiratory muscles strength after COVID-19
Authors: Savushkina O. I. , Zaicev A. A. , Kryukov E. V , Astanin P. A , Aseeva N. A , Malashenko M. M. , Fesenko O. V. 
Published: February 2023

The respiratory pump that provides pulmonary ventilation includes the respiratory center, peripheral nervous system, chest and respiratory muscles.The aim of this study was to evaluate the activity of the respiratory center and the respiratory muscles strength after COVID-19 (COronaVIrus Disease 2019).Methods. The observational retrospective cross-sectional study included 74 post-COVID-19 patients (56 (76%) men, median age – 48 years). Spirometry, body plethysmography, measurement of lung diffusing capacity (DLCO), maximal inspiratory and expiratory pressures (MIP and MEP), and airway occlusion pressure after 0.1 sec (P0.1) were performed. In addition, dyspnea was assessed in 31 patients using the mMRC scale and muscle strength was assessed in 27 of those patients using MRC Weakness scale.Results. The median time from the COVID-19 onset to pulmonary function tests (PFTs) was 120 days. The total sample was divided into 2 subgroups: 1 – P0.1 ≤ 0.15 kPa (norm), 2 – > 0.15 kPa. The lung volumes, airway resistance, MIP, and MEP were within normal values in most patients, whereas DLCO was reduced in 59% of cases in both the total sample and the subgroups. Mild dyspnea and a slight decrease in muscle strength were also detected. Statistically significant differences between the subgroups were found in the lung volumes (lower) and airway resistance (higher) in subgroup 2. Correlation analysis revealed moderate negative correlations between P0.1 and ventilation parameters.Conclusion. Measurement of P0.1 is a simple and non-invasive method for assessing pulmonary function. In our study, an increase in P0.1 was detected in 45% of post-COVID-19 cases, possibly due to impaired pulmonary mechanics despite the preserved pulmonary ventilation as well as normal MIP and MEP values.
Bronchodilator therapy in patients with chronic obstructive pulmonary disease: what should be considered in clinical practice when choosing a dosing regimen?
Authors: Titova O. N. , Kuzubova N. A. , Kozyrev A. G. , Shumilov A. A. 
Published: February 2023

The use of long-acting bronchodilators is central to the chronic obstructive pulmonary disease (COPD) therapy. One of the goals of bronchodilation is to reduce the morning COPD symptoms that are associated with a more severe disease and an increased risk of exacerbations.The aim of the study was to evaluate the clinical efficacy of switching COPD patients with severe morning symptoms who received combinations of long-acting bronchodilators QD to a fixed-dose combination of aclidinium bromide (AB) and formoterol fumarate (FF) BID.Methods. We examined COPD patients treated with combinations of long-acting β2-agonists and M-anticholinergics (but not AB and FF), who continued to complain of severe symptoms in the morning despite the treatment. After examination, the patients were switched to the fixed-dose combination of AB 0.4 mg and FF 0.012 mg (AB/FF) BID in the form of a metered-dose powder inhaler. The patients were examined at baseline and at 6-month follow-up.Results. Of the 115 included COPD patients, 90 completed the study. After 6 months of treatment, they showed a significant decrease in the intensity of cough, sputum amount, severity of distant wheezing, and shortness of breath in the morning (–0.88, –0.38, –0.29, –0.58 on a 4-point scale, the mean score –0.44; p < 0.001). The result of the COPD Assessment test decreased from 28 (24; 34) to 24 (20; 28) (p = 0.011), the distance of a 6-minute walk increased from 319 ± 72 to 354 ± 67 m (p < 0.001). The fixed-dose combination of AB/FF did not cause serious adverse events.Conclusion. The fixed-dose AB/FF combination in COPD patients resulted in a significant clinical improvement and was well tolerated. The AB/FF combination with twice daily dosing regimen is advisable for the patients with morning symptoms persisting despite therapy with other combinations of long-acting bronchodilators with once daily dosing regimen.
Efficacy and safety of bovhyaluronidase azoximer (Longidase) in patients with post-COVID syndrome: results of an open, prospective, controlled, comparative, multicenter clinical trial DISSOLVE
Authors: Chuchalin A. G. , Yablonskiy P. K. , Rubanik T. V. , Chernyavskaya O. A. , Naumov V. V. , Korneva L. I. , Kudelуa L. M. , Petukhova A. Yu. , Masalkina O. V. , Argamakova Yu. V. , Ignatova G. L. , Borisov A. G. , Kasyanova T. R. , Suleymanova A. K. 
Published: February 2023

Post-COVID syndrome develops after COVID-19 (COronaVIrus Disease 2019) and leads to cumulative effects in the form of shortness of breath and impaired lung function. Notably, patients with airway inflammation and COVID-19 were found to have increased concentrations of hyaluronic acid (HA). Since bovhyaluronidase azoximer (Longidase®) catalyzes the hydrolysis of HA, this drug has the potential to reduce HA levels and improve lung function in patients with post-COVID syndrome.The aim of the DISSOLVE trial, which was conducted early in the pandemic, was to investigate the efficacy and safety of bovhyaluronidase azoximer in patients with symptoms associated with post-COVID syndrome.Methods. An open, prospective, controlled, comparative, multicenter clinical trial (NCT04645368) included adult patients (n = 160) who had post-COVID syndrome. Patients in the treatment group (n = 81) received bovhyaluronidase azoximer, and individuals in the control group (n = 79) were followed up without intervention. The study included physical examination, evaluation of forced vital capacity (FVC), assessment of dyspnea with the Modified Medical Research Council Dyspnea Scale (mMRC), 6-minute walking test, and pulse oximetry. These indicators were measured on 3 visits, at days 1 (baseline), 75, and 180. In addition, the number of patients who experienced adverse events and serious adverse events were recorded.Results. Baseline patient characteristics in the treatment group and the control group were similar. In the treatment group, there was a statistically significant reduction in residual pulmonary abnormalities after visit 2 (day 75) and visit 3 (day 180). In addition, FVC, pulse oximetry values, and functional exercise tolerance increased statistically significantly at days 75 and 180 compared to baseline. The mMRC scores for dyspnea decreased statistically significantly in the treatment group over 75 days. The safety profile of the drug was reported to be favorable throughout the study. Conclusion. Treatment with bovhyaluronidase azoximer in patients with post-COVID syndrome showed improvement in FVC, pulse oximetry, functional exercise tolerance, and mMRC dyspnea.
Study of human ribosomal gene complex in cystic fibrosis
Authors: Kondratyeva E. I. , Ershova E. S. , Nikolaeva E. D. , Veyko N. N. , Sherman V. D. , Mel’yanovskaya Yu. L. , Krasovskiy S. A. , Kostyuk S. V. 
Published: February 2023

Increasing the life expectancy of patients with CF is an urgent healthcare task all over the world. According to the Register of patients with cystic fibrosis in the Russian Federation (2020), the number of patients over 18 years of age is 26.5%. Assumably, cystic fibrosis can be used as a model of accelerated aging to study the aging process in general.Aim of the study was to analyze the number of rDNA copies in a sample of cystic fibrosis patients at different ages and with lethal outcome in relation to lung function, complications, and respiratory tract infections.Methods. We studied DNA samples isolated by the standard method from peripheral blood leukocytes of 277 patients diagnosed with cystic fibrosis. 998 DNA samples from healthy volunteers were used as a control group.Results. The study showed that the genomes of patients with CF contain more rDNA copies than those of control patients. The greatest number of copies of ribosomal genes was observed in DNA samples from deceased patients (p < 0.001) and was associated with more severe disease course. Among all CF patients, the largest number of rDNA copies in the genome was registered in patients with the lowest FEV1 values (less than 40%). It was found that patients with chronic Burkholderia cepacia complex infection had a significantly higher number of copies of ribosomal repeats than the total sample (p = 0.001) and the adults (p = 0.014). The number of ribosomal repeats did not differ between patients with other chronic respiratory tract infections.Conclusion. In the group of deceased patients, the patients with low respiratory function and Burkholderia cepacia complex infection had the highest number of rDNA copies in the genome, and the differences were significant. It can be assumed that the number of rDNA copies in the genome of CF patients is an additional prognostic marker that is associated with the patient’s life expectancy.
Treatment, diagnostics, and management of chronic obstructive pulmonary disease in women
Authors: Malykhin F. T. , Baturin V. A. 
Published: February 2023

Chronic obstructive pulmonary disease (COPD) poses a significant burden on women’s health. Insufficient attention is paid to this problem in scientific research and in clinical practice, although more and more information surfaces about the gender-associated differences in the treatment, diagnostics, and management of COPD.The aim of the review is to consider the most significant data currently available on the clinical signs, course, and outcomes of COPD in women and propose ways to achieve the best results in the diagnosis and treatment of this disease.Conclusion. There are biological and cultural differences between the clinical manifestations, course and outcome of COPD in men and women, and these differences impact the clinical practice. It is advisable to apply individualized diagnostic, organizational, and pharmacotherapeutic approaches to COPD in women, based on the knowledge of female-specific variances in the symptoms of the disease and the health status.
On the pathogenesis of destructive pneumonia during COVID-19: a clinical case
Authors: Zaytseva O. V. , Tolstova E. М. , Khaspekov D. V. , Tkachenko N. V. , Scholohova N. A. , Simonovskaya H. Yu. , Belyaeva Т. Yu. 
Published: February 2023

Community-acquired pneumonia is a potentially serious infection in children with high morbidity rate, risk of severe course and unfavorable outcomes. Specialists have noted the increased incidence of the destructive forms in the recent years.Aim. To present a clinical case of destructive pneumonia in a 1 year 2 month old child, hospitalized in the State Budgetary Healthcare Institution “Children’s City Clinical Hospital of St. Vladimir Moscow Healthcare Department”, and analyze it in terms of current understanding on the disease pathogenesis.Conclusion. During COVID-19 (COronaVIrus Disease 2019) pandemic, pulmonologists and pediatric surgeons encountered an unconventional course of destructive pneumonia. A large number of studies of pathophysiological processes in acute viral interstitial pneumonias have recently allowed to expand our understanding of the role of coagulation system. At the same time, new questions arose concerning the clinical course and development of the pathological infectious process.
Organization of biological therapy for patients with severe eosinophilic bronchial asthma in the Krasnoyarsk region
Authors: Demko I. V. , Sobko E. A. , Kraposhina A. Yu. , Shestakova N. A. 
Published: February 2023

Patients with severe bronchial asthma, which remains uncontrolled despite the optimal basic therapy, carry a significant healthcare burden and require substantial financial investments. Severe asthma is a heterogeneous airway disease with complex pathophysiological mechanisms that can be broadly divided into inflammatory pathways with eosinophilic and non-eosinophilic inflammation.Aim. This study aimed to analyze the literature data on the use of targeted genetic engineering therapy in patients with severe bronchial asthma, as well as to analyze the organization of immunobiological therapy in the Krasnoyarsk Territory. The addition of targeted drugs for severe eosinophilic bronchial asthma based on phenotyping has proven to be effective and is recommended by all current guidelines. Today, several biologics targeting specific endotypes and phenotypes has been approved for the treatment of severe eosinophilic asthma worldwide. These are antibodies binding immunoglobulin E (omalizumab), antagonists of interleukin-5 (mepolizumab, reslizumab) and its receptor (benralizumab), as well as antibodies selectively binding to the IL-4 and IL-13 receptors (dupilumab). Eosinophilic inflammation therapy is a relatively new direction of asthma treatment, and understanding its long-term efficacy and safety is important.Conclusion. It is essential to differentiate patients with severe eosinophilic asthma from the general cohort of asthma patients, timely refer them to specialists who can prescribe this therapy and have experience with it, select the drug correctly, and monitor the patients during the treatment. This article describes organization of biological therapy for patients with severe eosinophilic bronchial asthma in the Krasnoyarsk Territory.
Inhaled corticosteroids administration/withdrawal as a therapeutic continuum for patients with chronic obstructive pulmonary disease in real clinical practice
Authors: Avdeev S. N. , Aisanov Z. R. , Arkhipov V. V. , Belevskiy A. S. , Vizel A. A. , Demko I. V. , Emelyanov A. V. , Zaycev A. A. , Ignatova G. L. , Kniajeskaia N. P. , Kudelya L. M. , Leshchenko I. V. , Ovcharenko S. I. , Sinopalnikov A. I. , Trofimenko I. N. , Fedotov V. D. , Khamitov R. F. 
Published: February 2023

Chronic obstructive pulmonary disease (COPD) is a progressing disease. Each exacerbation impairs the patient’s prognosis and increases burden for the healthcare system. The most common maintenance treatment options for COPD include long-acting bronchodilators – β2-agonists (LABA) and long-acting antimuscarinic agents (LAMA), and inhaled glucocorticosteroids (ICS), in fixed/opened double and triple combinations. Triple therapy in subjects with exacerbation history is the most effective way to prevent negative outcomes of the disease. It can reduce the frequency of exacerbations, slow down the disease progression, improve quality of life, and reduce mortality in the long run. On the other hand, the response to triple therapy may change over the time depending on airways inflammation level, infection activity, and exacerbation frequency. Current COPD guidelines propose different indications for therapy escalation and de-escalation (ICS addition/withdrawal) for more personalized and safe treatment. At the same time, many practical issues of this process are still unclear, e.g. how often treatment regimens should be reviewed and what escalation/de-escalation criteria should be prioritized. The authors strongly believe that COPD therapy should adapt a holistic treatment approach (continuum) with quick responses to any changes in the patient’s condition.The aim of our work was to create an algorithm for ICS administration/ withdrawal for COPD patients on long-acting dual bronchodilators maintenance therapy and to establish a therapeutic continuum that takes into account exacerbation history, symptoms severity, blood eosinophilia level, and concomitant asthma.Conclusion. This instrument can be a useful and convenient tool for long-term patient management when access to specialized medical care might be restricted. It takes into account the main current recommendations for COPD management and is easy to apply in real clinical practice.
Necrotizing fasciitis in the form of Fournier gangrene in a 70 year old patient
Authors: Arslani Nuhi , Mikuljan Timotej 
Published: February 2023

Purpose: In this case report, we describe a patient with Fournier gangrene, as well as his treatmentcourse and management.
Case report: A 70-year-old male was hospitalized for Fournier gangrene in the perianal region. We performed radical necrectomy, drainage of perianal abscess, and transversostomy. Based on wound culture results, Amoksiklav and Ciprobay were administered. The complication of decompensated adhesive ileus occurred, which required reoperative intervention.
Conclusion: Fournier gangrene is a rare disease that usually affects males. The disease begins withswelling, cellulitis, fever, and odor. We successfully treated this disease with emergency surgery and reoperative intervention.
Unintentional common carotid artery cannulation during attempted internal jugular venous catheter insertion
Authors: Janež Jurij , Marksl Janež Dragica 
Published: February 2023

Purpose: Insertion of a central venous catheter is a common procedure, performed by anesthesiologists and other medical professionals. The preferred site for central venous cannulation is the right internal jugular vein.
Case Report: We present the case of a male patient who underwent renal transplantation for end-stage renal disease. During preparation for surgery, the right common carotid artery was cannulated instead of the right internal jugular vein. The situation was immediately recognized and managed by a vascular surgeon. The patient recovered completely without neurological deficit.
Conclusion: Central venous cannulation is usually performed using the landmark technique. Incidental cannulation of the common carotid artery is a rare complication that can have serious consequences if not immediately recognized and properly managed.
Impact of hip and/or knee osteoarthrosis on quality of life
Authors: Kravos Andrej , Jerman Marta 
Published: February 2023

Purpose: Osteoarthritis is a chronic degenerative joint disease which has a significant impact on those with osteoarthritis. Osteoarthritis is the most common joint disease, and the prevalence increases with age. After cardiovascular diseases, osteoarthritis is the second most common cause of disability in developed countries. During the last few decades, questionnaires for health–related quality of life have been developed, which are important indicators of the outcomes of treatment of chronic diseases and are also predictors of mortality rates. The COOP/WONCA chart is a valid and reliable questionnaire which is easy to use and useful in family medicine practice.
Methods: The cross–sectional study evaluated the effect of hip and/or knee osteoarthritis on the quality of life. The patients included in our random sample were registered in GP surgery with radiologically confirmed disease. Data were collected on patient age and gender, work or job, associated diseases, frequency and type of exercise, and treatment and self–treatment of osteoarthritis. Each patient completed the COOP questionnaire. We analyzed different aspects of quality of life and the associationswith patient characteristics.
Results: One hundred fifty–five patients were enrolled and 131.patients returned the questionnaire. Patients had osteoarthritis involving the knee more often than osteoarthritis of the hip. Men underwent regular physical activity more often than women (p = 0.049). Women treated osteoarthritis more often than men (p = 0.038). Of the 155 patients, 43.5% had a moderate quality of life (score = 3), 46.6% had a poor quality of life (score = 4 and 5), and only 1.5% had a good quality of life (score = 1 and 2). Patients reported difficulty with physical fitness and overall health. The quality of life was worse in women, patients in the higher age groups, patients with limited or no physical activity, patients with involvement of more joints, and in patients with co–morbidities (except co–existing cardiovascular disease).
Conclusion: Patients with osteoarthritis of the hip and/or knee have a poor quality of life; specifically, such patientshave the greatest difficulty in engaging in physicalactivity and less social activity.
Strategi Penanganan Banjir Perkotaan pada Kecamatan Sumbersari, Kabupaten Jember
Authors: Alfiah Rindang , Aprilia Sonia Nuri , Hayati Nunung Nuring 
Published: February 2023

Bencana Banjir di Kabupaten Jember termasuk dalam bencana yang memiliki intensitas paling tinggi dibandingkan dengan jenis bencana yang lain. Salah satu kecamatan yang terdampak yaitu kecamatan Sumbersari dimana berdasarkan data BPBD Kabupaten Jember, dampak yang ditimbulkan oleh banjir di kecamatan Sumbersari cukup signifikan yaitu kerusakan bangunan, tempat ibadah dan sarana prasarana umum lainnya. Tingginya intensitas dan dampak yang ditimbulkan akibat banjir di Kecamatan Sumbersari perlu segera di selesaikan. Strategi penanganan yang tepat perlu direalisasikan agar banjir tidak terjadi secara terus menerus. Oleh karena itu, penelitian ini bertujuan untuk menysuun strategi penanganan banjir melalui evaluasi kebijakan menggunakan SWOT untuk merumuskan strategi penanganan banjir yang tepat untuk di terapakn di Kecamatan Sumbersari. Berdasarkan hasil analisis SWOT diketahui strategi yang tepat dalam menangani banjir di Kecamatan Sumbersari Kabupaten Jember adalah pengoptimalan Kekuatan dan Peluang dalam menangani banjir di kecamatan Sumbersari melalui pengembangan hutan kota, peningkatan kinerja infrastruktur, peningkatan pendanaan untuk penanganan pasca banjir, pengembangan pertanian Lahan kering, dan reboisasi.
The Sex Differences in Cortisol Concentrations, Anxiety, and Depressive Mood In Moroccan Youth
Authors: Rammouz Ismail , Nakajima Motohiro , Boujraf Saïd , Aalouane Rachid , Lemieux Andrine M. , al’Absi Mustafa 
Published: February 2023

Background:
Evidence indicates sex differences in stress response and mental health challenges. Psychobiological research of early symptoms of psychopathology has suggested that cortisol, as a marker of stress, is positively associated with depressive mood and anxiety in adolescents. To date, no study has examined sex differences in the relationships between cortisol levels and negative mood among Moroccan youth.

Methods:
A total of 332 Moroccan secondary students (171 female) aged 11 to 20 completed a range of psychological measures and provided two morning saliva samples across atwo-hour period. We hypothesized that females would show greater levels of depression and anxiety symptoms than males. We also anticipated positive relationships between cortisol and those symptoms.

Results and Discussion:
The results demonstrated the expected cortisol morning decline due to the diurnal pattern. Higher anxiety (p < .001), higher depressive mood (p < .001), and more clinically relevant depression were found in the females (47.7%) than the males (22.5%; p < .001). In addition, anxiety (p < .05) was positively associated with later morning cortisol in females but not males.

Conclusion:
Our results demonstrated sex differences in depressive mood among youth and the feasibility of psychobiological stress research in Morocco. More research is needed to identify sex-specific factors of depression and anxiety. Such effort would inform strategies to tailor treatment programs for females and males.