bluuebunny/crossref_metadata_2025_split huggingface dataset:
First Planar Binuclear Phthalocyanines Sharing a Common Carbazole Linkage: Synthesis, Optical and Photochemical Properties
Authors: Belousov Mikhail S , Okada Yusuke , Kobayashi Nagao , Martynov Alexander G , Gradova Margaret A , Konev Dmitry V , Goncharova Olga A , Tafeenko Viktor A , Dubinina Tatiana V 
Published: January 2023

Abstract
The first examples of planar binuclear phthalocyanines sharing a common carbazole unit were obtained using indirect and direct mixed cyclization approaches. The synthetic route to the starting 9-benzylcarbazole-2,3,6,7-tetranitrile was reconsidered and literature conditions were successfully optimized. In addition to the binuclear complex, a low-symmetry A3B phthalocyanine with free cyano groups was isolated and identified. Accurate assignment of absorption bands in the UV-Vis spectra was performed using magnetic circular dichroism and simplified TD-DFT calculations. The target binuclear complexes demonstrate the ability of singlet oxygen generation, with ΦΔ values reaching 0.15 for the tert-butyl-substituted compound. The products of photodegradation were studied using mass spectrometry and UV-Vis spectroscopy. Electrochemical and spectroelectrochemical studies showed a gradual oxidation of the macrocycle, accompanied by the interruption of an extended binuclear π-system.
Learning from success cases: ecological analysis of potential pathways to universal access to family planning care in low- and middle-income countries.
Authors: Hellwig Franciele , Barros Aluisio JD 
Published: January 2023

Background Universal access to family planning services is a well-recognized human right and several countries and organizations are committed to this goal. Our objective was to identify countries who improved family planning coverage in the last 40 years and investigate which contexts enabled those advances. Methods Analyses were based on data from publicly available national health surveys carried out since 1986 in Egypt, Ethiopia, Rwanda, Afghanistan, Brazil, and Ecuador, selected based on previous evidence. We estimated demand for family planning satisfied with modern methods (mDFPS) for each country and explored inequalities in terms of wealth, women’s education, and women’s age. We also explored contextual differences in terms of women’s empowerment, percentage of population living in extreme poverty, and share of each type of contraceptive. To better understand political and sociocultural contexts, country case studies were included, based on literature review. Results Patterns of mDFPS increase were distinct in the selected countries. Current level of mDFPS coverage ranged between 94% in Brazil and 38% in Afghanistan. All countries experienced an important reduction in both gender inequality and extreme poverty. According to the share of each type of contraceptive, most countries presented higher use of short-acting reversible methods. Exceptions were Ecuador, where the most used method is sterilization, and Egypt, which presented higher use of long-acting reversible methods. In the first years analyzed, all countries presented huge gaps in coverage according to wealth, women’s education and women’s age. All countries managed to increase coverage over recent years, especially among women from the more disadvantaged groups. Conclusions Family planning coverage increased along with reductions in poverty and gender inequality, with substantial increases in coverage among the most disadvantaged in recent years. Policies involving primary health care services, provision of various methods, and high quality training of health providers are crucial to increase coverage.
From High Bar to Uneven Bars: The Impact of Information Granularity in Quality Certification
Authors: Hui Xiang , Liu Zekun , Zhang Weiqing 
Published: January 2023

Quality certification is ubiquitously used in markets with asymmetric information, but little is known about the impact of the number of certification tiers on market outcomes. Exploiting a field experiment on a large e-commerce marketplace with an existing two-tier certification, we study the impact of introducing a new certification tier that is less history dependent and less demanding than the existing top tier. Consistent with the theoretical literature on information design, we find that the change in information granularity among the previously noncertified sellers increases demand for high-quality young sellers, incentivizes their quality provision, and increases their chance of eventually obtaining the top-tier certification. Moreover, the three-tier certification structure prompts established sellers with higher effort cost to reduce their effort, opt out of the top tier, and adopt the new tier instead. Lastly, we provide evidence that the net impact of introducing the new certification tier on seller effort depends on how history dependent the certification requirements are in a market. This paper was accepted by Eric Anderson, marketing. Supplemental Material: Data and the online appendix are available at https://doi.org/10.1287/mnsc.2022.4666 .
Supracrestal tissue attachment: an update
Authors: Shah Jaini , Webb Leah , McColl Ewen , Daldry Michael , Bhagi Serena , Witton Rob 
Published: January 2023

Supracrestal tissue attachment (STA) is a relatively new term that was introduced in 2017 following the World Workshop on the Classification of Periodontal and Peri-implant Diseases and Conditions, co-sponsored by the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP), which included expert participants from all over the world. It has replaced the term biological width, and refers to the junctional epithelium and supracrestal connective tissue. This article provides an updated review of the anatomy of STA, highlights the negative effects of violation and discusses its clinical relevance in restorative dentistry, including the use of crown lengthening. The impact of implants on STA is highlighted, and a summary of the relevance of STA in implant dentistry is also discussed. CPD/Clinical Relevance: To allow dental practitioners to have more confidence providing adequate function, comfort, and aesthetics in the dentition, while maintaining periodontal health.
Factor structure of Participation Behavioural Questionnaire (PBQ) in patients with hand injuries
Authors: Farzad Maryam , MacDermid Joy , Rassafiani Mehdi 
Published: January 2023

Background
Participation is considered a critical outcome of successful rehabilitation and should be evaluated.

Objective
We aimed to evaluate the structural validity of the Participation Behaviour Questionnaire (PBQ) in people with hand injuries.

Methodology
The PBQ contains 30 items that measure participation as conceptualized in the ICF. PBQ was developed with Rasch analysis to measure participation in hand injured. A sample of 404 patients with hand injuries and a mean age of 37 (16.0) participated and was randomly split for exploratory and confirmatory factor analysis (EFA/CFA).

Results
Both EFA and CFA confirmed a four factor-solution. These factors were named: Social Participation and Interpersonal Relationships, Autonomy and Role, Subjective Satisfaction with Participation, Recreational, Sport, and Leisure Time. The value of Cronbach’s alpha was 0.96 for the total scale and >0.85 for each subscale.

Conclusions
The structural validity of the PBQ was confirmed using both EFA and CFA. The PBQ measures four dimensions of participation.
Promoting early neovascularization by allotransplanted adipose-derived Muse cells in an ovine model of acute myocardial infarction
Authors: Castillo Martha G. , Peralta Tomás M. , Locatelli Paola , Velazquez Candela , Herrero Yamila , Crottogini Alberto J. , Olea Fernanda D. , Cuniberti Luis A. 
Published: January 2023

Background
Recent preclinical studies have demonstrated that bone marrow (BM)-derived Muse cells have a homing mechanism to reach damaged cardiac tissue while also being able to reduce myocardial infarct size and improve cardiac function; however, the potential of BM-Muse cells to foster new blood-vessel formation has not been fully assessed. Up to date, adipose tissue (AT)-derived Muse cells remain to be studied in acute myocardial infarction (AMI). The aim of the present study was to analyze in vitro and in vivo the neovascularization capacity of AT-Muse cells while exploring their biodistribution and differentiation potential in a translational ovine model of AMI.

Methods and results
AT-Muse cells were successfully isolated from ovine adipose tissue. In adult sheep, one or more diagonal branches of the left anterior descending coronary artery were permanently ligated for thirty minutes. Sheep were randomized in two groups and treated with intramyocardial injections: Vehicle (PBS, n = 4) and AT-Muse (2x107 AT-Muse cells labeled with PKH26 Red Fluorescent Dye, n = 4). Molecular characterization showed higher expression of angiogenic genes (VEGF, PGF and ANG) and increased number of tube formation in AT-Muse cells group compared to Adipose-derived mesenchymal stromal cells (ASCs) group. At 7 days post-IAM, the AT-Muse group showed significantly more arterioles and capillaries than the Vehicle group. Co-localization of PKH26+ cells with desmin, sarcomeric actin and troponin T implied the differentiation of Muse cells to a cardiac fate; moreover, PKH26+ cells also co-localized with a lectin marker, suggesting a possible differentiation to a vascular lineage.

Conclusion
Intramyocardially administered AT-Muse cells displayed a significant neovascularization activity and survival capacity in an ovine model of AMI.
Shifts in age pattern, timing of childbearing and trend in fertility level across six regions of Nigeria: Nigeria Demographic and Health Surveys from 2003–2018
Authors: Olowolafe Tubosun A. , Adebowale Ayo S. , Fagbamigbe Adeniyi F. , Bolarinwa Obasanjo Afolabi , Akinyemi Joshua O. 
Published: January 2023

Background
Nigeria’s population is projected to increase from 200 million in 2019 to 450 million in 2050 if the fertility level remains at the current level. Thus, we examined the shifts in the age pattern of fertility, timing of childbearing and trend in fertility levels from 2003 and 2018 across six regions of Nigeria.

Method
This study utilised the 2003, 2008, 2013, and 2018 Nigeria Demographic and Health Survey datasets. Each survey was a cross-sectional population-based design, and a two-stage cluster sampling technique was used to select women aged 15–49 years. The changes in the timing of childbearing were examined by calculating the corresponding mean ages at the birth of different birth orders for each birth order separately to adjust the Quantum effect for births. The Gompertz Relational Model was used to examine the age pattern of fertility and refined fertility level.

Result
In Nigeria, it was observed that there was a minimal decline in mean children ever born (CEB) between 2003 and 2018 across all maternal age groups except aged 20–24 years. The pattern of mean CEB by the age of mothers was the same across the Nigeria regions except in North West. Nigeria’s mean number of CEB to women aged 40–49 in 2003, 2008, 2013 and 2018 surveys was 6.7, 6.6, 6.3 and 6.1, respectively. The mean age (years) at first birth marginally increased from 21.3 in 2003 to 22.5 in 2018. In 2003, the mean age at first birth was highest in South East (24.3) and lowest in North East (19.4); while South West had the highest (24.4) and both North East and North West had the lowest (20.2) in 2018. Similar age patterns of fertility existed between 2003 and 2018 across the regions. Nigeria’s estimated total fertility level for 2003, 2008, 2013 and 2018 was 6.1, 6.1, 5.9 and 5.7, respectively.

Conclusion
The findings showed a reducing but slow fertility declines in Nigeria. The decline varied substantially across the regions. For a downward change in the level of fertility, policies that will constrict the spread of fertility distribution across the region in Nigeria must urgently be put in place.
Investigating the direct and indirect effects of a school-based leadership program for primary school students: Rationale and study protocol for the ‘Learning to Lead’ cluster randomised controlled trial
Authors: Wade Levi , Beauchamp Mark R. , Nathan Nicole , Smith Jordan J. , Leahy Angus A. , Kennedy Sarah G. , Boyer James , Bao Ran , Diallo Thierno M. O. , Vidal-Conti Josep , Lubans David R. 
Published: January 2023

Background
Leadership is a valuable skill that can be taught in school, and which may have benefits within and beyond the classroom. Learning to Lead (L2L) is a student-led, primary school-based leadership program whereby older ‘peer leaders’ deliver a fundamental movement skills (FMS) program to younger ‘peers’ within their own school.

Aim
The aims of the study are to determine the efficacy of a peer-led FMS intervention on: (i) peer leaders’ (aged 10 to 12 years) leadership effectiveness (primary outcome), leadership self-efficacy, well-being, and time on-task in the classroom; (ii) peers’ (aged 8 to 10 years) physical activity levels, actual and perceived FMS competency, cardiorespiratory fitness, muscular power, and executive functioning; and (iii) teachers’ (referred to as ‘school champions’) work-related stress and well-being.

Method
L2L will be evaluated using a two-arm parallel group cluster randomised controlled trial. Twenty schools located within a two-hour drive of the University of Newcastle, Australia will be recruited. We will recruit 80 students (40 peer leaders and 40 peers) from each school (N = 1,600). L2L will be implemented in three phases: Phase 1 –school champions’ training via a professional learning workshop; Phase 2 –school champions’ delivery of leadership lessons to the peer leaders; and Phase 3 –peer leaders’ delivery of the FMS program to their younger peers. The FMS program, consisting of 12 x 30-minute lessons, will be delivered over the course of one school term (10 weeks). Study outcomes will be assessed at baseline (between mid-March to June, Terms 1 and 2), intervention end (mid-August to September, Term 3), and follow-up (November to mid-December, Term 4. This trial was prospectively registered on the Australian New Zealand Clinical Trials Registry (ANZCTR); registration number: ACTRN12621000376842.
The added value of family-centered rounds in the hospital setting: A systematic review of systematic reviews
Authors: Woldring Josien M. , Luttik Marie Louise , Paans Wolter , Gans Reinold O. B. 
Published: January 2023

Background
Family engagement in care for adult inpatients may improve shared decision making in the hospital and the competence and preparedness of informal caregivers to take over the care at home. An important strategy to involve family members in hospital care processes is to include them in (ward) rounds, also called ‘family-centered rounds’(FCRs).

Objectives
Summarize the evidence regarding the added value of FCRs from the perspectives of patients, family, and healthcare professionals.

Methods
A review protocol was registered a priori with PROSPERO (number CRD42022320915). The electronic databases PubMed, CINAHL, and PsycInfo were searched for English-written systematic reviews with a focus on FCRs. The results and methods were presented in line with the PRISMA guidelines, and the methodological quality of the included reviews was assessed using the adapted version of the AMSTAR tool.

Results
Of the 207 initial records, four systematic reviews were identified covering a total of 67 single studies, mainly performed in critical and pediatric care. Added values of FCR were described at review level, with references to single studies. All four systematic reviews reported an improvement in satisfaction among patients, family, and healthcare professionals, whereby satisfaction is linked to improved communication and interaction, improved situational understanding, inclusion of family in the decision-making process, and improved relationships within the care situation.

Conclusion
Although only limited research has been conducted on the value of FCRs in the adult non-critical care setting, and despite the existence of a variety of outcome measures, the results available from the pediatric and acute care setting are positive. The findings of the sole study in an adult non-critical patient population are in line with these results. Further research in adult non-critical care is required to verify its effects in this setting.
Evaluating the cost-effectiveness of testing pregnant women for penicillin allergy
Authors: Thao Viengneesee , Sharpe Emily E. , Dholakia Ruchita , Ahn Hannah H. , Moriarty James P. , Borah Bijan J. , Gill Margaret C. , Theiler Regan N. 
Published: January 2023

Introduction
True penicillin allergy is rare and is commonly incorrectly reported. In fact, less than five percent of patients who report a penicillin allergy will have a currently active clinically-significant IgE- or T-cell-mediated hypersensitivity when appropriately tested. Penicillin is the agent of choice for intrapartum antibiotic prophylaxis to reduce the risk of group B streptococcus early-onset disease in the newborn. Inaccurate penicillin allergy status may lead to inappropriate antibiotic use, as most alternative drugs are more expensive and broader spectrum than penicillin. Penicillin allergy testing has been found to be safe in pregnancy and cost-effective in other patient populations.

Objective
To evaluate the cost-effectiveness of penicillin allergy testing and appropriate antibiotic treatment (test then treat strategy) compared to usual care among pregnant women.

Methods
We developed a decision tree to evaluate the cost of providing appropriate care via a test then treat strategy for pregnant women who report a penicillin allergy, compared to usual care.

Results
Using the test then treat strategy the additional cost to ensure appropriate care for all pregnant women who report a penicillin allergy, was $1122.38 per person. Adopting a test then treat strategy increased the number of appropriate antibiotic use from 7,843/10,000 to 10,000/10,000 simulations.

Conclusion
Our results show that a test then treat strategy for pregnant women who report a penicillin allergy is a good-value intervention.
Effect of acetazolamide on visuomotor performance at high altitude in healthy people 40 years of age or older—RCT
Authors: Reiser Aurelia E. , Furian Michael , Lichtblau Mona , Buergin Aline , Schneider Simon R. , Appenzeller Paula , Mayer Laura , Muralt Lara , Mademilov Maamed , Abdyraeva Ainura , Aidaralieva Shoira , Muratbekova Aibermet , Akylbekov Azamat , Sheraliev Ulan , Shabykeeva Saltanat , Sooronbaev Talant M. , Ulrich Silvia , Bloch Konrad E. 
Published: January 2023

Objective
Altitude travel is increasingly popular also for middle-aged and older tourists and professionals. Due to the sensitivity of the central nervous system to hypoxia, altitude exposure may impair visuomotor performance although this has not been extensively studied. Therefore, we investigated whether a sojourn at moderately high altitude is associated with visuomotor performance impairments in healthy adults, 40y of age or older, and whether this adverse altitude-effect can be prevented by acetazolamide, a drug used to prevent acute mountain sickness.

Methods
In this randomized placebo-controlled parallel-design trial, 59 healthy lowlanders, aged 40-75y, were assigned to acetazolamide (375 mg/day, n = 34) or placebo (n = 25), administered one day before ascent and while staying at high altitude (3100m). Visuomotor performance was assessed at 760m and 3100m after arrival and in the next morning (post-sleep) by a computer-assisted test (Motor-Task-Manager). It quantified deviation of a participant-controlled cursor affected by rotation during target tracking. Primary outcome was the directional error during post-sleep recall of adaptation to rotation estimated by multilevel linear regression modeling. Additionally, adaptation, immediate recall, and correct test execution were evaluated.

Results
Compared to 760m, assessments at 3100m with placebo revealed a mean (95%CI) increase in directional error during adaptation and immediate recall by 1.9° (0.2 to 3.5, p = 0.024) and 1.1° (0.4 to 1.8, p = 0.002), respectively. Post-sleep recall remained unchanged (p = NS), however post-sleep correct test execution was 14% less likely (9 to 19, p<0.001). Acetazolamide improved directional error during post-sleep recall by 5.6° (2.6 to 8.6, p<0.001) and post-sleep probability of correct test execution by 36% (30 to 42, p<0.001) compared to placebo.

Conclusion
In healthy individuals, 40y of age or older, altitude exposure impaired adaptation to and immediate recall and correct execution of a visuomotor task. Preventive acetazolamide treatment improved visuomotor performance after one night at altitude and increased the probability of correct test execution compared to placebo.

ClinicalTrials.gov identifier
ClinicalTrials.gov NCT03536520.
Midwives’ survey of their weight management practice before and after the GLOWING guideline implementation intervention: A pilot cluster randomised controlled trial
Authors: Heslehurst Nicola , McParlin Catherine , Sniehotta Falko F. , Rankin Judith , McColl Elaine 
Published: January 2023

Background
Maternal weight management is a priority due to pregnancy risks for women and babies. Interventions significantly improve maternal diet, physical activity, weight, and pregnancy outcomes. There are complex barriers to midwives’ implementation of guidelines; low self-efficacy is a core implementation barrier. The GLOWING intervention uses social cognitive theory (SCT) to address evidence-based barriers to practice. The intervention aimed to support midwives’ implementation of guidelines.

Methods
An external rehearsal pilot cluster randomised controlled trial in four NHS Trusts (clusters) in England, UK. Clusters were randomised to intervention (where all eligible midwives received the intervention) or control (no intervention delivered) arms. A random sample of 100 midwives were invited to complete questionnaires pre- and post-intervention. UK guideline recommendations relating to midwives’ practice were categorised into: 1) communication-related behaviours (including weight- and risk-communication), and 2) support/intervention-related behaviours (including diet/nutrition, physical activity, weight management, referrals/signposting). Questionnaires were developed using SCT constructs (self-efficacy, outcome expectancies, intentions, behaviours) and 7-point Likert scale, converted to a 0–100 scale. Higher scores were more positive. Descriptive statistics compared intervention and control arms, pre- and post-intervention.

Results
Seventy-four midwives consented and 68 returned questionnaires. Pre-intervention, self-efficacy for support/intervention-related behaviours scored lowest. In controls, there was limited difference between the pre- and post-intervention scores. Post-intervention, mean (SD) scores were consistently higher among intervention midwives than controls, particularly for support/intervention self-efficacy (71.4 (17.1) vs. 58.4 (20.1)). Mean (SD) self-efficacy was higher post-intervention than pre-intervention for all outcomes among intervention midwives, and consistently higher than controls. Mean differences pre- and post-intervention were greatest for support/intervention self-efficacy (17.92, 95% CI 7.78–28.07) and intentions (12.68, 95% CI 2.76–22.59). Self-efficacy was particularly increased for diet/nutrition and physical activity (MD 24.77, 95% CI 14.09–35.44) and weight management (18.88, 95% CI 7.88–29.88) behaviours, which showed the largest increase in scores.

Conclusions
This study supports the theoretical models used to develop GLOWING, where low self-efficacy was a core implementation barrier. Results suggest that GLOWING successfully targets self-efficacy, potentially with a positive impact on guideline implementation. A definitive trial is required to determine effectiveness.

Trial registration
ISRCTN46869894, retrospectively registered 25/05/2016, http://isrctn.com/ISRCTN46869894.