bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dimensions of Women Empowerment and its association with Utilization of Pregnancy Related Care Services in Selected Rural Area
Authors: Habiba Habiba , Rahman Zerin Shabnam , Ibrahim Fouzia , Fatema Tasnia , Noor Irfan Nowroze 
Published: September 2023

Abstract

Pregnancy-related care utilization is a fundamental urgency but family and community interference results in unattainability, though influence of different dimensions of women empowerment upon it is mostly unidentified. The study aims to identify the association between women empowerment dimensions and pregnancy-related care utilization. A cross-sectional study was conducted among conveniently selected 90 women attending purposively selected Chowgacha Upazila Health Complex, Jessore, for institutional normal vaginal delivery, between January and December, 2022. Maintaining human ethics protocol, an exit interview was done through a pretested semi-structured questionnaire. Women empowerment was assessed by a 3-point Likert scale under six dimensions (socio-cultural, educational, health-related, economic, technological, and life course) developed by country contextual modification of women empowerment index. Each dimension was recoded into two categories based on mean score. In multi-variate analysis, the health-related dimension was associated with iron-supplementation (OR=0.18; 95% CI 0.056-0.577), calcium-supplementation (OR=0.17; 95% CI 0.05-0.54), taking nutritious food (OR=0.07; 95% CI 0.02-0.29). The socio-cultural dimension was associated with nutritional supplementation (OR=0.17; 95% CI 0.04-0.7). The technological dimension was associated with ANC visits (OR=2.97; 95% CI 1.23-7.15). The economic dimension was associated with planned savings (OR=0.16; 95%CI 0.05-0.49). In bivariate analysis, the socio-cultural dimension was associated with frequency of meals (OR=11.1; 95%CI 1.4-89.1) and birth companionship (OR=3.3; 95%CI 1.4-8). The economic dimension was associated with frequency of meals (OR=7.22; 95% CI 1.4-33.6) and birth companionship (OR=2.7; 95% CI 1.1-6.4). The technological dimension was associated with frequency of meals (OR=4.9; 95%CI 1-23.3) and birth companionship (OR=2.7; 95% CI 1.1-6.5). The health-related dimension was found to be mostly associated with pregnancy-related care utilization. Hence, promotion of health-related dimension to enhance women empowerment could bring a successful pregnancy-related care utilization towards achieving SDG-5.
Immobilization of Microbial Cells in a Sol-Gel Matrix Using a Precursor with Two Non-Hydrolyzed Bonds
Authors: Lantsova Elizaveta A. , Kamanina Olga A. , Rybochkin Pavel V. , Arlyapov Vyacheslav A. , Saverina Evgeniya A. , Vereshchagin Anatoly N. 
Published: September 2023

Abstract

In this work, the yeast cells of Ogataea polymorpha BKM Y-2559 were immobilized in a organosilicon sol-gel membrane. It was shown that yeasts immobilized in a matrix containing 85 vol.% diethoxydimethylsilane (DMDES) and 15 vol.% tetraethoxysilane (TEOS) have the highest activity. Long-term storage of the resulting biohybrid material at a temperature of − 18 ºС demonstrated that the low temperature does not lead to a drop in the catalytic activity of the immobilized yeast. Maintaining the activity of the yeast encapsulated in the sol-gel matrix is important in the production and storage of commercial biocomposite samples. The study of the structure of the obtained material showed that the yeast cells of Ogataea polymorpha are located in the sol-gel matrix and are not able to be washed out, while the substrates and metabolites can diffuse to the cells without restrictions through the pores in the material.
Detection of quadratic phase coupling by cross-bicoherence and spectral Granger causality in bifrequencies interactions
Authors: Abe Takeshi , Asai Yoshiyuki , Lintas Alessandra , Villa Alessandro E.P. 
Published: September 2023

Abstract
Quadratic Phase Coupling (QPC) is a crucial statistical tool for assessing nonlinear synchronization within multivariate time series data, particularly within signal processing and neuroscience. This study delves into the accuracy of QPC detection by employing numerical estimates through cross-bicoherence and bivariate Granger causality within a simple yet noisy instantaneous multiplier model. The investigation extends to evaluating the influence of incidental statistically significant bifrequency interactions, introducing key metrics such as the ratio of bispectral quadratic phase coupling and the ratio of bivariate Granger causality quadratic phase coupling, with values close to 1 indicating high level of accuracy in QPC detection. The model is tested using 334 electroencephalographic recordings, encompassing diverse carrier frequencies to explore an extensive array of scenarios. The coupling strength between interacting channels emerges as a pivotal factor introducing nonlinearities that affect the signal-to-noise ratio in the output channel. The bispectral approach outperformed bivariate Granger causality, particularly at weak coupling strengths and with noise biases. Especially noteworthy is cross-bicoherence’s effectiveness in detecting QPC in cases of very weak couplings, making it a reliable method for unveiling subtle nonlinear interactions in noisy signals, a common scenario in brain activity recordings.
Leveraging physics-informed neural computing for real-world optimization tasks: From swinging up a pendulum to swingby of a spacecraft
Authors: Seo Jaemin 
Published: September 2023

Abstract
Optimization tasks are essential in modern engineering fields such as chip design, spacecraft trajectory determination, and reactor scenario development. Recently, machine learning applications, including deep reinforcement learning (RL) and genetic algorithms (GA), have emerged in these real-world optimization tasks. We introduce a new machine learning-based optimization scheme that incorporates physics with the operational objectives. This physics-informed neural network (PINN) could find the optimal path in well-defined systems with less exploration and also was capable of obtaining narrow and unstable solutions that have been challenging with shooting approaches like RL or GA. Through an objective function that integrates governing laws, constraints, and goals, PINN enables top-down searches for optimal solutions. In this study, we showcase the PINN applications to various optimization tasks, ranging from inverting a pendulum, determining the shortest-time path, to finding the swingby trajectory. Through this, we discuss how PINN can be applied in the tasks with different characteristics.
Machine Learning-Based Disulfidptosis-Related lncRNA Signature Predicts Prognosis, Immune Infiltration and Drug Sensitivity in Hepatocellular Carcinoma
Authors: Pu Lei , Sun Yan , Pu Cheng , Zhang Xiaoyan , Wang Dong , Liu Xingning , Guo Pin , Wang Bing , Xue Liang , Sun Peng 
Published: September 2023

Abstract
Disulfidptosis plays a crucial role in the development and progression of Hepatocellular Carcinoma (HCC). However, the significance of disulfidptosis-related Long non-coding RNAs (DRLs) in the prognosis and immunotherapy of HCC remains unclear. Based on The Cancer Genome Atlas (TCGA) database, we used Least Absolute Shrinkage and Selection Operator (LASSO) and Cox regression model to construct DRL Prognostic Signature (DRLPS)-based risk scores. Survival analysis was then performed and a nomogram was constructed. Moreover, we performed functional enrichment annotation, immune infiltration analyses and drug sensitivity analyses. Five DRLs, including AL590705.3, AC072054.1, AC069307.1, AC107959.3 and ZNF232-AS1, were identified to construct prognostic signature. DRLPS-based risk scores exhibited a better predictive efficacy of survival than conventional clinical features. The nomogram showed a high degree of congruence between the predicted survival and observed survival. Gene set were mainly enriched in cell proliferation, differentiation and growth function related pathways. Immune cell infiltration in the low-risk group was significantly higher than that in the high-risk group. Additionally, the high-risk group exhibited higher sensitivity to Afatinib, Fulvestrant, Gefitinib, Osimertinib, Sapitinib, and Taselisib. In conclusion, our study highlighted the potential utility of the constructed DRLPS in the prognosis prediction of HCC patients, which demonstrated promising clinical application value.
Trends in Antiosteoporosis Use in Nine Major Areas In China younger than 50 years old From 2016 to 2019
Authors: Bo Chen , Chen Liying , Li Liu-Cheng , Yu Zhenwei , Sun Yanting , Wang Yuzhen , Chen Wang , Wang Siqi , Hu Yan , Kan Lian-Di 
Published: September 2023

Abstract
Purpose
This study aimed to assess the national trends in osteoporosis prescriptions among Chinese adult outpatients aged less than 50 years with osteoporosis from 2016 to 2019.
Patients and methods:
Prescriptions for adult outpatients with osteoporosis from hospitals in nine major areas were extracted from the database of the Hospitals Prescription Analysis Cooperative Project. Trends in the annual prescriptions and expenditures for osteoporosis were analyzed.
Results
The number of osteoporosis hospital visits showed an increasing trend year by year from 18412 in 2016 to 23447 in 2019 (P = 0.029), and the corresponding cost increased from 2083872.94 Chinese Yuan (CNY) to 2643508.59 CNY in 2019 (P = 0.032). The results showed that the share of newer osteoporotic use of medicines increased continuously, accounting for 34.3% of prescriptions and 26.8% of expenditures in 2019. The study found that in osteoporosis hospital visits under 50 years of age, the use of medicine increased year by year. However, bone resorption inhibitors and bone formation promoters in this group did not change significantly, accounting for only a small proportion.
Conclusion
The development of osteoporosis prescriptions in this study reflected the current situation of research in China. Meanwhile, in this study, we also investigated the epidemiology of osteoporosis in China in patients under 50 years of age, for whom the incidence of osteoporosis showed an increasing trend, which reminded us to accelerate the prevention of osteoporosis.
Results of N=1 randomized, double-blind, placebo-controlled, cross-over discontinuation trials embedded in clinical practice after longer term methylphenidate use: A pilot study
Authors: Rosenau Paul T. , Dietrich Andrea , Hoofdakker Barbara J. van den , Hoekstra Pieter J. 
Published: September 2023

Abstract

Background
Attention-deficit/hyperactivity (ADHD) guidelines recommend that the need for continued stimulant medication treatment of children and adolescents needs to be reviewed at least annually. We aimed to assess the outcomes in clinical practice of placebo-controlled discontinuation trials after long-term methylphenidate treatment.
Method
We asked clinicians to implement N=1 randomized, double-blind, placebo-controlled, cross-over discontinuation trials after at least one year of methylphenidate treatment of children and adolescents (n = 26, 6 – 15 years of age). We analyzed the effectiveness of ongoing methylphenidate treatment compared to placebo on symptoms of ADHD, oppositional defiant disorder, and conduct disorder according to both parents and teachers, and the global improvement or deterioration according to the clinicians. We also assessed the proportion of individuals who continued using methylphenidate after the discontinuation trial.
Results
Teacher-rated hyperactivity and impulsivity symptoms were significantly lower during methylphenidate treatment compared to placebo (β = 3.80, SD = 1.69, t = 2.25, p = .04). No other significant differences were found between methylphenidate and placebo. Almost two-thirds (n = 16, 61.5%) of individuals continued using methylphenidate after the discontinuation trials, of which 7 did not deteriorate during placebo according to their clinician.
Discussion
Our findings support the need for regular evaluations of methylphenidate treatment effectiveness and emphasize the importance of including the school setting when evaluating treatments. Better guidance for clinicians when to continue or cease methylphenidate treatment is urgently needed.
Plasmodium falciparum remains the dominant parasite affecting children despite decades of implementing vector control in two villages in Humbo district of Wolita zone, southwest Ethiopia
Authors: Elias Shimels , Massebo Fekadu 
Published: September 2023

Abstract
Background
Malaria is still a significant public health concern, and its prevention and control measures have different impacts depending on the location. This study assesses the prevalence of malaria and the effectiveness of routine malaria control programmes such as indoor residual spray (IRS) in two Ethiopian villages.
Methods
The villages were purposefully selected based on their malaria prevalence rates. A parasitological survey was carried out in Fango-Gelchecha before and after the implementation of IRS. In Shochora-Abela, the survey was conducted only after the implementation of IRS. IRS was part of the standard malaria control programme, and 300 households in each village were selected systematically by selecting every fourth house from the village registration list. A total of 3075 individuals were counted and enrolled for malaria testing using microscopy.
Results
After three to four months of IRS application, there were 59 confirmed malaria cases with an overall prevalence of 1.9% (95% CI: 1.5–2.5). Of the positive cases, 18 cases (0.59%: 95% CI: 1.3–1.8) were from Shochora-Abela village, and 41 cases (1.33%: 95% CI: 1.1–1.3) were from Fango-Gelchecha. About age categories, the prevalence of malaria was 10.1% (95% CI: 5.9–15.9) among children under five, 4.7% (95% CI: 3.3–6.4) in children aged 5–14, and only 0.32% (95% CI: 0.13–0.67) in the age group 15 and above. Overall, P. falciparum was the dominant malaria parasite, accounting for 69.5% (95% CI: 56.1–80.8), while P. vivax malaria accounted for 30.5% (95% CI: 19.2–43.8). The malaria prevalence in Fango-Gelchecha village was 3.1% (95% CI: 2.3-4.0) before IRS and 2.6% (95% CI: 1.8–3.5) after IRS application. In the village of Shochora-Abela, the prevalence of IRS was 1.2% (95% CI: 0.7–1.9), but the prevalence prior to IRS was not evaluated.
Conclusions
Plasmodium falciparum is the predominant parasite in the villages, which mainly affects children under five years of age. Therefore, protecting young children should be the priority of concerned organizations to reduce the infection burden.
Teosinte and modern maize use different C allocation strategies in response to organic N amendment
Authors: Hwang Siwook , Machmuller Megan B. , Gaudin Amélie C. M. , Fonte Steven J. 
Published: September 2023

Abstract
Background and Aim
With a growing focus on soil health, modern agroecosystems have begun to emphasize greater reliance on organic nitrogen (N) sources to meet crop N demands. Teosinte (Zea mays subsp. parviglumis), a wild relative of modern maize (Zea mays subsp. mays), is believed to modulate its belowground carbon (C) allocation based on the type of N in the soil, thus allowing for greater organic N uptake. However, linkages between belowground allocation and N acquisition from organic vs. inorganic N sources remain poorly understood.
Methods
We designed a 13C/15N dual label experiment in which we compared the C allocation patterns of modern maize and teosinte in response to inorganic (urea) and organic (cover crop residue) forms of N.
Results
Teosinte responded to organic N by increasing its biomass root-to-shoot (R:S) ratio by 50% compared to inorganic N, while modern maize maintained the same biomass R:S ratios in both N treatments. Recent photosynthate R:S ratio was greater in organic N than in inorganic N for both modern maize and teosinte (91% and 37%; respectively). Label-derived dissolved organic C, representing recent rhizodeposits, was 2.5 times greater in the organic N treatments for both genotypes.
Conclusion
Modern maize took up a similar amount of organic N as teosinte using different C allocation strategies. Our findings suggest that intensive breeding under high N input conditions has not affected modern maize’s access to organic N while improving its ability to take up inorganic N.
Recruitment of Hippocampal and Thalamic Pathways to the Central Amygdala in the Control of Feeding Behavior Under Novelty
Authors: Greiner Eliza M. , Petrovich Gorica 
Published: September 2023

Abstract

It is adaptive to restrict eating under uncertainty, such as during habituation to novel foods and unfamiliar environments. However, sustained restrictive eating is a core symptom of eating disorders and has serious long-term health consequences. Current therapeutic efforts are limited, because the neural substrates of restrictive eating are poorly understood. Using a model of feeding avoidance under novelty, our recent study identified forebrain activation patterns and found evidence that the central nucleus of the amygdala (CEA) is a core integrating node. The current study analyzed the activity of CEA inputs in male and female rats to determine if specific pathways are recruited during feeding under novelty. Recruitment of direct inputs from the paraventricular nucleus of the thalamus (PVT), the infralimbic cortex (ILA), the agranular insular cortex (AI), the hippocampal ventral field CA1, and the bed nucleus of the stria terminals (BST) was assessed with combined retrograde tract tracing and Fos induction analysis. The study found that during consumption of a novel food in a novel environment, larger number of neurons within the PVTp and the CA1 that send monosynaptic inputs to the CEA were recruited compared to controls that consumed familiar food in a familiar environment. The ILA, AI, and BST inputs to the CEA were similarly recruited across conditions. There were no sex differences in activation of any of the pathways analyzed. These results suggest that the PVTp-CEA and CA1-CEA pathways underlie feeding inhibition during novelty and could be potential sites of malfunction in excessive food avoidance.
Another Derived Modification of the Geometric Weighted Weibull Distribution
Authors: Muddey Donne Komla , Sarpong Solomon , Katara Salifu , Akuamoah Saviour Worlanyo 
Published: September 2023

Abstract

The aim of this generalization is to introduce a new modified weighted Weibull distribution called geometric weighted Weibull that was derived from the concept of the weighted distribution to provide better flexibility extension and tractability of the mathematical concepts of the weighted Weibull distribution. The major statistical and mathematical concepts the researchers adopted were parameter estimation, goodness-of-fit test, hazard function, quantile, survival function, entropy, and order statistics. The method of maximum likelihood estimation was adopted to estimate the unknown four parameters of the Geometric weighted Weibull distribution. The Monte Carlo simulation method is discussed using the quantile function to examine the performance of the parameters. The processes were performed using R-Software. A new modification of the Geometric weighted Weibull distribution is derived, and its probability characteristics are obtained. The shapes of the probability density function and hazard rate functions are investigated. The geometric weighted Weibull model assumes superior performance among the compared distributions, as evidenced by the Kolmogorov-Smirnov statistics and Akaike Information Criteria values.
Association of MYOC Gln368Ter mutation and glaucoma: a systematic review and meta-analysis
Authors: Das# Soumik , Sharma# Poonam , Prakki# Vasantica , Prakki# Viswadica , V Devi Rajeswari , Ramanathan Gnanasambandan 
Published: September 2023

Abstract

Background
Glaucoma is a group of eye conditions that damage the optic nerve. Elevated eye pressure is frequently associated with optic nerve damage, which may result in lifelong blindness. Glaucoma and the Myocilin (Gln368Ter) mutation have been linked in several populations, and this relationship may serve as a biomarker.
Methods
To investigate the connection between glaucoma and the Gln368Ter mutation of the myocilin gene, a meta-analysis was done from eight published genetic-associated case-control studies. RevMan 5.4.1, a meta-analysis software, was used to analyze heterogeneity across separate studies and summarise their effects.
Results
Glaucoma and Myocilin (Gln368Ter) mutation showed a summed odds ratio of 4.11 (95% CI, 0.09-185.43). The study groups showed significant heterogeneity (p < 0.00001 and I2 = 100%). However, glaucoma and myocilin (Gln368Ter) mutation were not significantly correlated (p = 0.64).
Conclusion
There was no association was observed between MYOC (Gln368Ter) mutation and Glaucoma across the studies. However, the increased risk was observed from our metanalysis.
Identification and Validation of Cuproptosis-Related Genes in Prognosis and immune microenvironment in colon cancer patients
Authors: Jinghui Zhang , Wenhao Man , Yuru Zhang 
Published: September 2023

Abstract
Recently, the copper-induced regulated cell death form that depends on mitochondrial respiration was identified as cuproptosis. However, the potential roles of cuproptosis-related genes(CRGs) with tumor prognosis and tumor microenvironment(TME) in colon cancer(CC) patients remain unclear. From four independent databases, we characterized the set of CRGs in 1124 CC samples from the fields of genetic and transcriptional, then evaluated their expression patterns. We identified two CRGclusters, and found distinguishing clinicopathological features, prognosis, and TME cell infiltrating characteristics correlated with CRGs expression. Moreover, a predictable risk score for overall-survival (OS) was established and its predictive capability in CC patients was validated. Subsequently, the nomogram was constructed to improve the risk score's clinical features applicability. The high-risk level, characterized by an increased proportion of mutation burden, microsatellite instability-high (MSI-H), and immune cell infiltration, indicates the potential for immunotherapy response. Our analysis of CRGs in CC demonstrated their potential roles in the tumor-immune-stromal microenvironment, clinicopathological features, and prognosis. These findings may improve our understanding of CRGs in CC and pave a new path for the assessment of prognosis and the development of more effective immunotherapy strategies.