bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network Pharmacology Unveils Multi-Systemic Intervention of Panax notoginseng in Osteoporosis via Key Genes and Signaling Pathways
Authors: Wang Qiyue , Wang Xiaoping , Wu Kezhou , Wu Weiwei , Wei Zhantu , Feng Weili 
Published: January 2025

Background:
Panax notoginseng (Burk.) F. H. Chen (PN) is a traditional Chinese
medicine that has been applied to prevent and treat osteoporosis. The mechanism of PN for osteoporosis
remained a mystery.

Objective:
The objective was to reveal the therapeutic effect and illuminate the possible mechanism
of PN for osteoporosis.

Methods:
The Traditional Chinese Medicine Database and Analysis Platform was searched to
screen the potent ingredients of the PN and to analyze the potential therapeutic targets for osteoporosis.
We excavated four disease databases to collect osteoporosis-related genes. After integrating
the gene expression profile of osteoporosis and the chemical-protein data of PN, a protein-protein
interaction network was constructed to demonstrate the interactions among the gene products.
GO function, KEGG pathway, and docking analyses were executed.

Results:
Network pharmacology obtained 31 active ingredients and 134 targets for the treatment
of osteoporosis. The key components were beta-elemene, quercetin, methyl palmitate, oleic acid,
and hexanal. The results of GO and KEGG analyses showed that Panax notoginseng was beneficial
for osteoporosis by influencing the main pathways including AGE-RAGE signaling pathway
in diabetic complications, TNF signaling pathway, IL-17 signaling pathway, p53 signaling pathway,
NF-kappa B signaling pathway, PI3K-Akt signaling pathway, MAPK signaling pathway,
FoxO signaling pathway, and Wnt signaling pathway, modulating inflammation, metabolism, cell
proliferation, cell survival, growth and angiogenesis. Panax notoginseng intervened in osteoporosis
through multi-components, multi-targets, and multi-pathways.

Conclusion:
This study illustrates the mechanism of Panax notoginseng for osteoporosis, providing
broader insights for novel research and developments of the Panax species for osteoporosis.
Development of Stabilized and Aqueous Dissolvable Nanosuspension Encompassing BCS Class IV Drug via Optimization of Process and Formulation Variables
Authors: Goel Surya , Agarwal Vijay , Sachdeva Monika 
Published: January 2025

Background:
Nanosuspension has emerged as an effective, lucrative, and unequalled approach
for efficiently elevating the dissolution and bioavailability of aqueous soluble drugs. Diverse
challenges persist within this domain, demanding further comprehensive investigation and exploration.

Objective:
This study aims to design, develop, optimise formulation and process variables, and
characterise the stabilised aqueous dissolvable nanosuspension using chlorthalidone as a BCS class-
IV drug.

Methods:
Nanosuspensions of the chlorthalidone drug were prepared using a combination of topdown
and bottom-up approaches. Various polymers such as Pluronic L-64, F-68, F-127, and
Synperonic F-108 were used as stabilisers in this research. All important processes and formulation
variables, such as ultrasonication intensity and time, the concentration of the drug, organic solvent,
and stabilisers that may critically influence the characteristics of the nanosuspensions, were optimised.
Formulation screening was performed using the optimisation of process and formulation variables,
and the optimised nanosuspension formulation was assessed for particle size, PDI, surface
charge, morphology, in vitro drug release, and stability.

Results:
To select an optimised nanosuspension formulation, the effects of formulation and process
variables were investigated. These variables critically influence the development of a stabilised
nanosuspension. The outcomes revealed that the nanosuspension formulation containing pluronic F-
68 as a stabiliser in 0.6% w/v concentration and the drug in 4 mg/ml concentration were optimized.
The particle size and zeta potential of the optimised preparation were 110 nm and -27.5 mV, respectively.
The in-vitro drug release of chlorthalidone drug from the optimised nanoformulation was increased
up to 3-fold, approximately (88% in 90 min) compared with pure chlorthalidone drug (27%
in 90 min) because of the decrease in particle size. Moreover, stability studies indicated that the
crafted nanoformulation was stable at cold (4℃) as well as normal room temperature (25℃) for six
months.

Conclusion:
From the obtained results, it was concluded that the combination of top-down and bottom-
up approaches employed for the fabrication of oral nanosuspension is a remunerative and lucrative
approach to successfully resolve the perplexities associated with the dissolution rate of poorly
aqueous soluble BCS class-IV drug moieties such as chlorthalidone.
PREDICTION OF CONVERSION OF LAPAROSCOPIC CHOLECYSTECTOMY TO OPEN CHOLECYSTECTOMY USING A PREOPERATIVE SCORING SYSTEM
Authors: KOLA CHANDRASEKHAR REDDY  , SASIDHARA RAO A  , JAYADURGA CHALAMALASETTY  , PRERANA RAJU GUDIMETLA  , SRIDHAR PUNYAPU  , RAVI GANJI  
Published: January 2025

Objectives: The objectiveof the study is To use the Risk Score to predict conversion of laparoscopic cholecystectomy to open cholecystectomy and to evaluate whether this scoring method can be used routinely.
Methods : A Prospective Observational Clinical study conducted in 106 cases who underwent elective laparoscopic cholecystectomy were analysed prospectively both preoperatively and postoperatively using the scoring system.
Results: A total of 106 patients were studied. The highest incidence of gallstone in present series is in the age group of 30 to 40 years. The gender ratio (Male: Female) is 1: 2.3. Of the 106 patients, all had cholelithiasis, 6 patients had GB wall thickening, 1 had impacted stone and none had peri-cholecystic collection. In the present study, Age >50, BMI >;27.5, H/O prior hospitalization for acute cholecystitis, wall thickening, vomiting’s, were significant predictors of difficult laparoscopic cholecystectomy. The conversion rate from laparoscopic cholecystectomy to open cholecystectomy was 12.3%. Of the total 19 cases falling under moderate risk 12 were converted to open cholecystectomy. Rest was managed and completed by laparoscopically. Only one case in the mild risk group was converted to open, reason being the short cystic duct. The most common intraoperative reason for conversion was adhesions in 10 patients, followed by frozen calots, short cystic duct and Mirizzi syndrome. The positive predictive value for easy prediction was 100%.
Conclusion: The scoring system used has got better significance in prediction of conversion from lap to open cholecystectomy.
Geoquímica ambiental de los isótopos estables de Zinc
Authors: Carrillo-Chávez Alejandro , Calvo-Ramos Daniela K. , Rueda-Garzón Luisa F. , Corona-Martínez Liliana , Muñoz-Torres Carolina , García-Martínez Rocío 
Published: January 2025

La geoquímica ambiental de los isótopos estables del zinc (Zn) es un campo de investigación relativamente nuevo que se centra en la comprensión de los ciclos geoquímico y biogeoquímico del Zn en los sistemas naturales, usando el fraccionamiento isotópico del Zn como trazador de diversos procesos. Los isótopos de Zn son sensibles a una amplia gama de condiciones ambientales, incluidos los cambios en los estados de oxidación, la absorción biológica y la meteorización mineral. Esto los convierte en herramientas valiosas para estudiar las influencias tanto naturales como antropogénicas en el medio ambiente. En general, el Zn es unos de los metales más usados por la industria, es esencial en procesos orgánicos metabólicos (incluidos losdel ser humano) y es tóxico en altas concentraciones. Los isótopos de Zn se han utilizado para rastrear fuentes de contaminación en suelos y aguas, especialmente en zonas afectadas por actividades mineras y emisiones industriales, apoyando así las evaluaciones geoquímicas ambientales, y en las estrategias de remediación. La geoquímica de isótopos estables del Zn tiene implicaciones en varios campos de las geociencias, ciencias bioquímicas e incluso en las ciencias médicas. En este artículo se da información general de fuentes naturales de Zn, algunos de sus usos industriales, el Zn como elemento esencial en metabolismo orgánico y su toxicidad. El principal enfoque está centrado en analizar algunos procesos de fraccionamiento isotópico, explicar de manera general sus aplicaciones, definir las metodologías de preparación de muestras en laboratorio, así como los métodos analíticos modernos para medir el fraccionamiento isotópico del Zn, y finalmente presentar algunos datos preliminares de mediciones isotópicas de Zn de proyectos vigentes en Instituto de Geociencias-UNAM, Campus Juriquilla.
¿Una Tierra sin campo magnético? Un fenómeno comprendido hasta 1919
Authors: Chacón-Hernández Francisco 
Published: January 2025

Al día de hoy, diferentes estudios nos han permitido conocer más sobre el origen, comportamiento y funcionamiento del campo magnético de la Tierra (cmT). Este fenómeno, cuyo conocimiento ha requerido de siglos de observaciones y estudios para responder inquietudes e interrogantes milenarios, aún plantea ciertas dudas sobre su pleno funcionamiento. No obstante, durante el siglo XVII, la pregunta que muchos hacían sobre si la Tierra era en sí un campo magnético gigante que seguía los principios físicos de un imán, comenzó a ser cada vez más considerada. Esto permitió obtener a principios del siglo XX, en el año de 1919, evidencias concretas solo de carácter empírico y experimental que permitieron hacer las primeras suposiciones sobre el origen del cmT, correlacionando sus causas-efectos e integrando los diferentes tipos de mecanismos y fenómenos que ocurren en el interior y exterior de la Tierra. Por tanto, en este escrito, se volverá al pasado para intentar revisar aquellos supuestos milenarios que se hicieron sobre el magnetismo y el cmT. Así mismo, se explica de forma general y sin detalles técnicos el origen y funcionamiento del cmT, lo que en realidad representa este fenómeno y cómo éste guarda correlación con el funcionamiento total del planeta Tierra en constante evolución.
Environment as a Victim: overcoming the human-centric Paradigm of Rights
Authors: Sanabria-Rangel Alvaro Augusto 
Published: January 2025

The present article evaluates the profound impact that recognizing the environment as a potential victim has for the enforceability of environmental rights and the particularities of the Latin American juridical systems that have been critical in this development affecting how environmental rights and protections are considered, in particular the understanding of the environment as a victim. In the 1990s, the In Dubio Pro Natura principle was developed via judicial decisions. This principle is understood as a separate principle of international law that requires authorities to interpret laws and regulations in the most favourable manner to the interests of nature. In the first decade of the 2000s, Ecuador and Bolivia constitutionalized environmental rights. This process embraced non-western legal approaches and traditions from indigenous peoples. More recently, Colombia’s restorative justice system has acknowledged the environment as a direct victim of their internal armed conflict. The process that has taken place in the Latin-American region represents a case study on challenging the human-centred paradigm of rights. This article discusses the significance and potential of this recognition for the enforceability of environmental rights.

RESUMEN: El presente artículo evalúa el profundo impacto que el reconocimiento del ambiente como una potencial víctima tiene para la exigibilidad de los derechos ambientales y las particularidades de los sistemas jurídicos Latinoamericanos que han sido críticos para este desarrollo que afecta cómo los derechos ambientales y sus protecciones son evaluados, en particular la interpretación del ambiente como víctima. En la década de 1990, el principio In Dubio Pro Natura fue desarrollado por medio de decisiones judiciales. Este principio es entendido como un principio independiente de derecho internacional que exige a las autoridades interpretar las leyes y regulaciones de la forma más favorable a los intereses de la naturaleza. En la primera década del siglo XXI, Ecuador y Bolivia constitucionalizaron los derechos ambientales. Este proceso acogió enfoques y tradiciones no occidentales provenientes de los pueblos indígenas. Más recientemente, el sistema de justicia restaurativa de Colombia ha reconocido al ambiente como víctima directa de su conflicto interno armado. El proceso que ha tenido lugar en Latinoamérica representa un caso de estudio que cuestiona el paradigma humanocentrista de los derechos. Este artículo discute la importancia y potencial de este reconocimiento para la exigibilidad de los derechos ambientales.
PERAN MODERASI RELIGIOUS COPING TERHADAP HUBUNGAN RESILIENSI DAN KUALITAS HIDUP PADA PEREMPUAN DENGAN INFERTILITAS
Authors: Lisyanti  , Kilis Grace 
Published: January 2025

Perempuan dengan infertilitas di Indonesia seringkali melibatkan keyakinan pada Tuhan, baik secara positif maupun negatif, sebagai coping menghadapi stres infertilitas. Tujuan penelitian kuantitatif ini adalah untuk melihat apakah religious coping (the Brief Religious Coping) memoderasi hubungan antara resiliensi (Connor-Davidson Resilience Scale 25) dan kualitas hidup (WHO Quality of Life Brief). Data dikumpulkan dari 135 perempuan (mean usia 27,8 tahun, SD = 3,58) yang mempersepsi sedang menghadapi kondisi infertilitas yakni sudah menikah minimal satu tahun, tidak sedang menunda kehamilan dengan mengusahakan kehamilan melalui cara alami ataupun program hamil, dan belum berhasil memiliki anak serta menunjukkan stres infertilitas yang tinggi. Hasil uji moderasi menunjukkan hipotesis 1 dan 2 penelitian ditolak, yaitu baik positive religious coping maupun negative religious coping tidak memoderasi hubungan antara resiliensi dan masing-masing dimensi kualitas hidup. Meskipun demikian, uji korelasi menunjukkan temuan menarik adanya korelasi positif antara negative religious coping dengan resiliensi dan dimensi environment. Penelitian ini menunjukkan pentingnya penyediaan sarana-prasarana, seperti informasi kesehatan, layanan konseling, dan komunitas pendukung untuk meningkatkan kemampuan bangkit dalam menghadapi stres infertilitas.
Analysis of the modern nature of bankruptcy institution in the Russian Federation
Authors: Mostovaya L. A. , Antonov S. A. 
Published: January 2025

The purposes of this article are to reasonably determine the nature of the institution of bankruptcy and assess its impact on law enforcement practice. The basic methods of the article are: historical review, substantive (content) analysis, causal analysis, statistical (horizontal and vertical) research of data on bankruptcy procedures, observation of consequences. Methodologically, the work is based on a brief description of historical milestones in the development of the institute of bankruptcy and on the analysis of the transformation of understanding the essence of the concept of insolvency in various editions of the Federal law. Then causal relationships are established, reflecting the key changes in the current Federal law No. 127 of October 26, 2002 and a hypothesis is expressed about the liquidation nature of the institution. Using open statistical data from official bodies and current research by specialists on the subject of the article, the authors reasonably confirm the initial hypothesis (quantitative characteristics are given). The work is completed with an assessment of the impact of the liquidation nature of the bankruptcy institution on the law enforcement practice and the negative consequences of this state of affairs are revealed, which necessitates (determines the expediency) an additional study of the causes. The main results of the article can be applied in the practice of teaching such disciplines as anti-crisis management, legal foundations of insolvency (bankruptcy), arbitration process. A fairly clear justification of the nature and consequences of the functioning of the modern institution of bankruptcy can be considered a contribution to science. Practical usefulness is manifested in the indication of weak points of the legislation that are applied for the purpose of unfair enrichment.
Additional sources of financing for the updated national development goals
Authors: Chmut G. A. 
Published: January 2025

National development goals are the basis of public policy and combine labour and material resources to address key development issues. They are approved by the decree of the President of the Russian Federation (hereinafter referred to as RF, Russia). For the first time, the RF’s national development goals were described in the Presidential Decree No. 204 and included a development perspective until 2024. In 2020, due to the challenges associated with the spread of COVID-19, the Decree of the President of the RF No. 474 clarified the list of national goals and extended their implementation period until 2030. The national development goals set by 2030 included such key areas as population preservation, human health and well-being; opportunities for self-realisation and talent development; comfortable and safe living environment; decent, effective work and successful entrepreneurship as well as digital transformation. In May 2024, the national goals were updated again by the Presidential Decree No. 309. The main reasons were ensuring sustainable economic and social development of the RF, improving living standards and increasing the population, ensuring state and public security as well as strengthening state and economic sovereignty. The purposes of this article are to review the updated national development goals, objectives and identify sources of their financing. As the study results, the activity of the Government of the RF in finding the sources of financing for the updated national projects is analysed. The main conclusion of the article is the justification of additional sources of financing to achieve the national development goals.
Application of a discrete approach to designing the transport component of municipal solid waste logistics
Authors: Vitvitsky E. E. , Galaktionova E. S. , Yuryeva N. I. 
Published: January 2025

Introduction. The growth of the urban area has led to the need to transfer landfills for the disposal of solid municipal (household) waste (MSW) to more remote locations on new sites. Representations and approaches to cargo transportation planning are an essential factor, separate planning of individual applications does not allow determining the results of future work with sufficient accuracy, since such an approach does not allow taking into account the interaction of rolling stock from different routes with each other and loading machines. The purpose of the study is to design the transportation of MSW in regional communications based on a discrete approach and theoretical provisions of operational planning of road freight transportation.Materials and methods. Within the framework of the conducted research, a normative approach was applied to the planning of freight transportation costs and descriptive models for describing the functioning of road transport systems of regional road freight transportation.Results and discussion. The solution of tasks related to the design of cargo transportation, including in regional communications, is due to the need in advance, prior to experience, knowledge of the results of future activities, since it is impossible to accumulate the work of road transport and then fix it. The results of cargo transportation depend on many factors, including the availability of a design methodology that allows you to adequately reflect the processes of their implementation. The use of mathematical modeling made it possible to reliably build plans for the transportation of MSW and determine the cost of their implementation.Conclusion. It has been revealed that possible downtime of both road trains and excavators is the reason for not fulfilling the operational transportation plan defined by separate planning. The use of the same rolling stock for customers with different transportation distances in the region will be accompanied by different costs.
Changes in the thermophysical and mechanical properties of blocked soils during compaction and the promotion
Authors: Kuznetsov I. S. , Sirotiuk V. V. , Orlov P. V. , Kuznetsova V. N. 
Published: January 2025

Introduction. It is known that flooded, blocked soils prevail in the North of Russia and in the territory of its Arctic zone. Such soils have a low bearing capacity, which reduces the possibility of their use in the construction of winter roads. Compaction (crimping) of blocked soils changes their thermophysical and physico-mechanical properties by changing the modes of freezing and thawing of weak bases, as well as the bearing capacity of overland winter trucks in wetlands. The article reflects the results of experimental studies of changes in the thermophysical and physico-mechanical parameters of the blocked soil at different degrees of its compaction.Methods and materials. Low-moisture soil with a high content of organic matter (peat) of more than 50% was used for research. It was compacted with loads, the magnitude of which is typical for sealing (crimping) operations of weak blocked bases on autosomes (0.01, 0.03 and 0.06 MPa), and frozen in a chamber to a temperature of -15 °C. Temperature control was carried out at different depths at predetermined intervals. To do this, we put together a device, the main elements of which are DS18B20 brand thermal sensors and an Arduino Nano microcontroller. The thermal conductivity of thawed and frozen soil was determined using the MIT-1 probe device. A dynamic density meter D-51 was used to determine the strength (hardness) of the samplesand the universal penetrometer PUS-3M.Results. The properties of the studied organic soil have been clarified. The heat capacity of this soil is determined depending on its humidity, temperature and density. The influence of the degree of soil compaction on the kinetics of its freezing is estimated. The results of the study of the dependence of the conditional strength (hardness) of the soil at different temperatures and densities, as well as the results of the interpretation of the results of dynamic zonation and the modulus of elasticity for the studied blocked soil are presented.Conclusion. Compaction (crimping) of the blocked soil increases its thermal conductivity and the rate of freezing of the upper layer of the swamp, which helps to accelerate the commissioning of the winter truck. Compaction (crimping) of the blocked soil significantly increases its strength during freezing, which determines an increase in the bearing capacity of autozymers in swamps. The most promising use for operational control of the density and strength of a frozen peat slab on autozymers is dynamic sensing methods with penetrometers of various designs. The results of determining the conditional strength index (hardness) of peat soil using probing with a dynamic density meter and a universal penetrometer are obtained.