bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual & reproductive health information on minor consent forms for pubertal suppression and gender affirming hormones
Authors: Taylor Julia , Vullikanti Meesha , Nelamangala Samhita L. , Boguszewski Katherine E. , Marshall Mary Faith 
Published: April 2023

IntroductionTransgender and Nonbinary (TNB) youth need specialized sexual and reproductive health (SRH) information and counseling. One avenue for providing this information is the use of informed consent documents before initiating pubertal suppression (PS) and/or gender-affirming hormones (GAHs). This study aims to compare the type and amount of SRH information included on informed consent documents used across clinical sites providing PS and GAH to youth.MethodsAs part of a larger, IRB-approved survey on informed consent, providers of gender-related care to youth uploaded informed consent forms used in clinical practice. Publicly available forms were also included in analysis. Content analysis of these forms was undertaken using published clinical guidelines to inform coding and reflect the SRH implications of starting PS and GAH.Results21 unique consent documents were included in the content analysis (PS = 7, Masculinizing = 7, Feminizing = 7). SRH information on consent documents fell into 4 broad categories: (1) changes in sexual organs and functioning; (2) pregnancy and fertility information; (3) cancer risk; and (4) sexually transmitted infections. Forms varied considerably in the level of detail included about these SRH topics and most forms included implicit or explicit acknowledgement of the uncertainty that exists around certain SRH outcomes for TNB youth.ConclusionsThere was substantial variability in both SRH content and context across consent forms. The role of consent forms in fostering TNB youth's understanding of complex SHR information when initiating PS and GAHs needs further clarification and development. Future research should focus on ways to ensure provision of adequate SRH information for TNB youth.
Surgical management of chronic calcific deposit resembling tendon sheath infection in the index finger: A rare case report and literature review
Authors: Guo Deming , Yang Jingjing , Liu Xiaoning 
Published: April 2023

BackgroundCalcific tendonitis rarely occurs in the fingers, and it is easily misdiagnosed. Herein we describe the case of a patient with multiple calcific lesions within the flexor digitorum superficialis and the extensor digitorum tendons of the distal interphalangeal joints of the right index finger, and the surgical treatment of those lesions.Case presentationThe patient was a 66-year-old man who reported pain and swelling in his right index finger for one year. He was diagnosed with chronic calcific tendonitis based on his symptoms and radiology images. He was successfully treated surgically, and histopathological examination confirmed the diagnosis. After one month, the patient had healed well, and there was no recurrence.ConclusionsThis is the first report of a patient suffering from chronic calcific tendonitis in a finger who failed conservative treatment and was successfully treated with surgery. The outcome demonstrates that surgical debridement can yield a good outcome in patients with chronic calcific tendonitis.
Case report: Circulating tumor DNA technology displays temporal and spatial heterogeneity in Waldenström macroglobulinemia during treatment with BTK inhibitors
Authors: Zhu Jingjing , Zhu Xinyu , Xie Fengyang , Ding Yi , Lu Huina , Dong Yan , Li Ping , Fu Jianfei , Liang Aibin , Zeng Yu , Xiu Bing 
Published: April 2023

Background: Waldenström macroglobulinemia (WM) is a rare subtype of B-cell lymphoma. Rituximab-based combination therapy and Bruton’s tyrosine kinase (BTK) inhibitors have greatly improved the prognosis of WM. Despite the high response rate and good tolerance of BTK inhibitors in treatment of WM, a proportion of patients still experience disease progression.Case presentation: We report a 55-year-old man with relapsed WM. The patient achieved partial remission after six courses of CHOP chemotherapy and multiple plasma exchanges in initial treatment. He was admitted to the hospital with abdominal distension, and was diagnosed with relapsed WM and subsequently started on zanubrutinib. Disease progression and histological transformation occurred during treatment. We performed liquid biopsies on transformed plasma, tumor tissue and ascites at the same time and found high consistency between ascites and tissues. Moreover, we detected resistance mutations of BTK inhibitors (BTK, PLCG2) in ascites that were not detected in plasma or tissue. Eventually, the patient died during the 15-month follow-up after relapse.Conclusion: We describe a rare case of WM transformation to DLCBCL treated with chemoimmunotherapy and BTK inhibition. We analyzed tumor DNA obtained at different anatomic sites and circulating tumor DNA (ctDNA) derived from plasma and ascites specimens, with apparent significant temporal and spatial heterogeneity. The case specifically highlights the clinical value of ctDNA of ascites supernatant from WM patients, which is a more convenient and relatively noninvasive method compared with traditional invasive tissue biopsy.
Exploring the Applied Heart of the Church: The Retributive vs. Restorative Justice Perspectives on Punishment and Incarceration
Authors: Jacob Anupama , Asbill Michelle , Tauati Amy 
Published: April 2023

Mass incarceration is one of the key societal issues facing the US today. While numerous factors have contributed to this problem, a major one is the punitive approach of our criminal justice system. This paper examines the underlying justifications for our criminal justice system’s emphasis on punishment using Christian and dominant cultural frameworks. The primary objectives of this paper are: (1) to compare and contrast the core tenets and values of two distinct philosophical approaches to punishment - retribution and restoration - both of which are active within the US criminal justice system; (2) to explore how these two approaches align with biblical values of justice, grace, mercy, and atonement; and (3) to discuss practical implications for how Christian social work educators, scholars, and practitioners can advocate for criminal justice reform based on clear Christian convictions.
A Comprehensive Assessment of Rehabilitation Potential in Patients with Neuropathies
Authors: Чапко И.Я. , Филиппович А.Н. , Овсянник Ю.А. , Перкова В.Е. 
Published: April 2023

Введение. Реабилитационный потенциал представляет совокупность потенциальных возможностей пациента, основанную на комплексной экспертно-реабилитационной диагностике, определяющей прогноз эффективности медицинской реабилитации, максимальную возможность восстановления или компенсации нарушенных функций органов и систем организма. Цель. Разработать метод оценки реабилитационного потенциала пациентов с травматическими и компрессионно-ишемическими невропатиями. Материалы и методы. В исследование включены 62 пациента в возрасте от 18 до 63 лет с наличием периферического вялого пареза различной степени выраженности (62 чел., 100%), алгического синдрома (33 чел., 53,2%), нейротрофическими (23 чел., 37,1%) и вегетососудистыми нарушениями (14 чел., 22,6%). Результаты. Определение реабилитационного потенциала целесообразно выполнять на основе анализа трех групп факторов: медицинских, психологических, социальных, а также с использованием оценки функций, структур, активности и участия. С учетом положений Международной классификации функционирования, ограничений жизнедеятельности и здоровья были выделены критерии, характеризующие высокий, средний и низкий потенциал. Заключение. Оценка реабилитационного потенциала учитывалась при формировании реабилитационного диагноза и составлении индивидуальной программы медицинской реабилитации, абилитации пациента, позволяла определить задачи реабилитации для мультидисциплинарной реабилитационной бригады.
Introduction. Rehabilitation potential represents the overall potential of a patient, based on a comprehensive expert and rehabilitation diagnosis, which determines the prognosis for medical rehabilitation efficiency, the maximum possibility of restoring or compensating for impaired functions of organs and body systems. Purpose. To elaborate a method for rehabilitation potential assessment in patients with traumatic and compression ischemic neuropathies. Materials and methods. The study included 62 patients aged 18 to 63 years with peripheral flaccid paresis of varying severity (62 subjects, 100%), algic syndrome (33 subjects, 53.2%), neurotrophic (23 subjects, 37.1%) and vegetative-vascular disorders (14 subjects, 22.6%). Results. It is expedient to determine the rehabilitation potential based on the analysis of three groups of factors: medical, psychological, social, as well as using an assessment of functions, structures, activity and participation. Taking into account the provisions of the International Classification of Functioning, Disabilities and Health, criteria were identified characterizing high, medium and low potential. Conclusion. The assessment of rehabilitation potential was taken into account when formulating a rehabilitation diagnosis and drawing up an individual program of medical rehabilitation and habilitation for each patient, allowing to determine rehabilitation tasks for a multidisciplinary rehabilitation team.
Factors Associated with Nurses’ Attitude towards Patient Safety Culture in an International Accredited Tertiary Care Hospital, Islamabad
Authors: Kausar Raisa , Janjua Kholood , Siddique Mainmoona , Victor Gideon 
Published: April 2023

Background: Patient safety has emerged as a prime agenda over the past few decades to deliver safe care in increasingly complex service delivery. This study was set out to measure the factors associated with the safety attitudes of nurses.
Methodology: This descriptive cross-sectional research was conducted from May 2017 to June 2018 in Shifa International Hospital, Islamabad. Nurses were invited to participate in the study. The safety attitude questionnaire was used for data collection. Data were analyzed using SPSS v23.0.
Results: The response rate was 86%. Job satisfaction was high at 78.37±23.63 while stress recognition was low at 53.18±27.68. Nurses liked their job being a nurse 79.92±28.01 and workplace conditions 80.33±26.44. Whereas, hostile situations 48.92±34.95, the negative effect of fatigue 48.50±35.32, being held back to report patient problems 47.58±34.76 and discuss errors 45.42±34.79 were also highlighted. Safety attitudes were statistically significant high among intensive care nurses (P-Value < 0.05). Safety scores of nurses with longer job duration were high than those with lesser job duration. Teamwork was favorably correlated with safety climate, job satisfaction, perception of management, and working conditions (R > .466, P-Value < .01).
Conclusion: There was a positive attitude of nurses toward patients’ safety with some areas of improvement.
Keywords: Attitude, Nurse, Patient safety, Practice
Clinicopathological Features and Expression of Ki-67 in Odontogenic Keratocyst, Dentigerous Cyst and Radicular Cyst
Authors: Rasul Faiz , Saif Rabiya , Jehangir Hafiz Majid , Rizvi Zainab , Wahid Sultan , Nadeem Khurram 
Published: April 2023

Background: Biological behaviour of Odontogenic Keratocyst (OKC) is aggressiveness than others Odontogenic Cysts (OCs) like Dentigerous Cyst (DCs) and Periapical Cyst/Residual Cysts (RCs). The aim of the study was to determine clinicopathological features and expression of Ki-67 in Odontogenic Cysts of the oral cavity.
Methodology: This cross-sectional study was conducted at de’Montmorency College of Dentistry (DCD from Feb, 2020 to Feb, 2022 after approval from Institutional Review Board (IRB) of DCD. A total 78 cases of OCs were collected from hospitals which are affiliated with the DCD. Routine lab process for Hematoxylin & Eosin and Immunohistochemistry was performed. Data entry and statistical analysis was carried out in SPSS 21. A Chi- square test was applied to observe the association between cyst and Ki-67. P value < 0.05 was taken as statistically significant.
Results: Among total 78 cases the mean age was 25.08 ±14.5 years with an age range of 6-70 years. Most OCs (64.1%) were reported in males than females (35.89%). Most OCs were reported in mandible (56.4%. Ki-67 expression in OKC was high 7.7%, low in 76.9% and negative in 15.4%). Most of the DCs and RCs expressed low expression of Ki-67 (84.6% and 76.9% respectively).
Conclusion: Most of the odontogenic cysts expressed low expression of Ki-67 while few cases of OKC and DC expressed high expression.
Keywords: Dentigerous Cyst, Odontogenic Keratocyst, Immunohistochemistry, Ki-67, Odontogenic Cysts, Periapical Cyst, Radicular Cyst.
Evaluation the Role of Vitamin C in the IUI-Treatment of Female Infertility
Authors: Hashim Batool Abdulwahid , Al-Ghazali Basima Shamkhi 
Published: April 2023

Background: the prevalence of female infertility ranges between 7% to 28% depending on the age of the woman, however ovulatory disorder can be seen in fifths of infertile women. In a healthy body, ROS (Reactive Oxygen Species) and antioxidants remain in balance, when the balance is disrupted towards an overabundance of ROS; Oxidative stress (OS) occurs. Oxidative stress markers have been localized in follicular fluid of subfertile women undergoing assisted reproduction, Low intrafollicular oxygenation has been associated with decreased oocyte developmental potential. Vitamin C (ascorbic acid) is required for the synthesis of collagen, for the synthesis of steroid and peptide hormones, and it protects tissues of oxidative damage. There is an abundance of ascorbic acid in the ovary, which is consistent with its known roles in hormone synthesis and synergism with neurotransmitters in stimulating hormone secretion.
Objective: The aim of our study is to evaluate the role of Vitamin C in the treatment of female infertility, with outcomes measured by total number of follicles, follicular size, endometrial thickness, and pregnancy outcome.
Methodology: Randomized, controlled, group- comparative study by taking two groups and observe them to study the effect of adding vitamin C on infertility treatment of half of them. 50 women on induction of ovulation prepared for (IUI) with no vitamin C in their treatment and (50 women) prepared for (IUI) with vitamin C of 500-1000mg daily in their treatment and follow up them by serial ultrasound measurement for number of ovarian follicles, follicular diameter and endometrial thickness and pregnancy outcome.
Result: Follicular diameters, follicular numbers, endometrial thickness at day 10 of cycle, and pregnancy rate in group receiving vitamin C were all higher than group that who are not taking vitamin C.
Conclusion: Vitamin C has a role in female reproduction as it can improve the number, diameter of follicles, endometrial thickness and thereby pregnancy outcome.
ANALISIS TREN KONTEN PADA VTUBER INDONESIA MENGGUNAKAN LATENT DIRICHLET ALLOCATION
Authors: Akdeas Oktanae Widodo  , Septiadi Farhan , Nur Aini Rakhmawati  
Published: April 2023

YouTube merupakan bukti dari perkembangan teknologi digital terbaru dalam bidang media dan hiburan. Tidak semua youtuber atau orang yang membuat konten video di YouTube melakukan ekspresi diri secara langsung, ada yang menggunakan perantara karakter virtual dua dimensi atau tiga dimensi yang dibuat dengan bantuan perangkat lunak computer untuk berinteraksi dengan penonton yang kedepannya biasa disebut sebagai Virtual Youtuber (VTuber). Tren vtuber ini mulai terkenal pada tahun 2016 di jepang makin tahun makin meningkat diseluruh dunia, Kemudian Semakin banyak orang-orang menyukai konten yang dibawakan oleh Vtuber dan tidak sedikit yang tertarik untuk menjadi bagian dari vtuber juga. Untuk membantu hal tersebut penelitian ini membantu untuk mengetahui topik konten yang ditayangkan oleh Vtuber Terkenal menggunakan metode Latent Dirichlet Allocation (LDA). Analisis dilakukan setelah menjalankan proses text mining terhadap 4312 video dari 10 channel vtuber Indonesia teratas. Penentuan topik yang optimal dari LDA yang diterapkan dapat melihat hasil nilai perplexity dan topic coherence. Dari implementasi metode LDA didapatkan hasil berupa lima topik yang sering ditayangkan oleh vtuber antara lain gim Minecraft dan reading donation, gim Apex Legend disertai collaboration dengan vtuber lain, tayangan siaran langsung video game, cover dari lagu penyanyi lain dan terakhir tayangan gim multiplayer lain seperti Raft atau Phasmophobia.
INVISIBLE WATERMARK PADA VIDEO DIGITAL MENGGUNAKAN METODE DINAMIC CELL SPREADING (DCS)
Authors: Muhammad Ikhsan  , Sriani  , Br tarigan Shania perida 
Published: April 2023

Menggunakan video digital tidak hanya mudah dalam hal distribusi, tetapi juga dalam proses penggandaan (copy) dan penyimpanannya untuk digunakan dimasa mendatang.Dampak kemudahan ini lah yang di salah gunakan tanpa memperhatikan aspek hak cipta (Intelectual Property Right), sehingga perlu dipikirkan adanya perlindungan terhadap hak cipta. Digital watermarking adalah solusi dan teknologi perlindungan hak cipta untuk penyematan informasi rahasia di media digital seperti gambar, teks, audio dan video.Informasi yang akan disisipkan harus dapat diambil kembali meskipun data di distribusikan secara digital. Pada penelitian ini untuk melindungi kepemilikan sebuah video digital akan dibangun sebuah aplikasi yang dapat memberikan watermark yang tak kasat mata. Proses pemberian watermark tersebut akan dilakukan menggunakan metode Dynamic Cell Spreading(DCS). Dynamic Cell Spreading (DCS) merupakan metode yang menggunakan model penyisipan yaitu menyembunyikan pesan (semua data elektronik)dimedia digital seperti video. Penelitian ini dikembangkan dengan software Android Studio menggunakan XML dan bahasa pemrograman Java Sehingga hasilnya dapat digunakan secara mobile pada perangkat android serta membangun sebuah aplikasi yang dapat menerapkan watermark tak kasat mata pada sebuah video digital yang dapat melindungi video hak milik.
ANALISA PERBANDINGAN TEKNIK OVERSAMPLING SMOTE PADA IMBALANCED DATA
Authors: Cosmas Haryawan  , Yosef Muria Kusuma Ardhana  
Published: April 2023

Data tidak seimbang atau lebih sering disebut imbalanced data, adalah kondisi pada saat data memiliki rasio yang tidak seimbang antara satu kelas dengan kelas yang lain, sehingga terdapat kelas mayoritas dan kelas minoritas. Sulit untuk membuat prediksi pada dataset yang tidak seimbang karena pengklasifikasi cenderung mendeteksi kelas mayoritas daripada kelas minoritas. Teknik resampling menjadi salah satu yang paling efektif dalam menyelesaikan permasalahan imbalanced data ini. Salah satu kategori dari teknik resampling adalah oversampling. Metode oversampling diantaranya adalah SMOTE dan K-Means SMOTE. Penggunaan oversampling akan meningkatkan hasil measurement klasifikasi. Penelitian ini menggunakan data wine yang memiliki 11 fitur serta 1 atribut target dan bertujuan untuk membandingkan hasil measurement antara penggunaan data sintetis hasil SMOTE dan K-Means SMOTE dengan hasil measurement penggunaan data nyata dalam kondisi data seimbang. Pembuatan data imbalance dilakukan dengan menghapus secara random salah satu kelas dengan ambang 25%, 50%, 60% dan 75%. Hasil penelitian menunjukkan bahwa dibandingkan penggunaan data nyata, penggunaan K-Means SMOTE cenderung menghasilkan nilai lebih tinggi untuk akurasi, sensitivitas dan spesifisitas sedangkan SMOTE meskipun memperoleh nilai yang lebih baik dibandingkan K-Means SMOTE tetapi juga terdapat beberapa kondisi imbalance yang memiliki nilai lebih tinggi dibandingkan penggunaan data nyata.
Application of the cost-effectiveness method in improving the pharmacotherapy of multiple myeloma
Authors: Luchinin E. A. , Zhuravleva M. V. , Shelekhova T. V. , Bogova V. S. , Luchinina E. V. 
Published: April 2023

Multiple myeloma (MM) accounts for 1 % of all cancers and about 10 % of all hemoblastoses. The use of innovative technologies with the inclusion of targeted drugs leads to a significant improvement in the quality of pharmacotherapy and the achievement of overall survival (OS).The aim of the work is to conduct a pharmacoeconomic analysis of the most used MM therapy regimens with the use of targeted drugs and to determine the dominant treatment regimens using a costeffectiveness analysis.Materials and methods. To determine the cost of a course of treatment, we summed up the costs of drugs included in the pharmacotherapy regimen, taking into account taxes, marginal trade markup and duration of the course. Dosing of the targeted drug included in the regimen was determined according to the official instructions for the drug. Progression-free survival (PFS) was adopted as the main criterion for the effectiveness of treatment. Information on PFS of targeted drugs was obtained from data from international phase III RCTs — ASPIRE, TOURMALINEMM1, POLLUX and ELOQUENT2.Results. Based on the results of the pharmacoeconomic analysis, the dominant treatment regimen for MM was determined — daratumumab / lenalidomide / dexamethasone, which has the best cost-effectiveness ratio. The combination of elotuzumab / lenalidomide / dexamethasone was recognized as the least effective technology.
Audits and inspections of pharmacovigilance systems in Russia
Authors: Taube A. A. , Romanov B. K. 
Published: April 2023

The implementation of pharmacovigilance activities is impossible in isolation from compliance with the quality requirements of medicines and the activities of pharmaceutical and medical organizations throughout the pharmaceutical practice, as well as without access to sales plans, sales results and full relevance of information on drug conditions in all markets and in all cases of application. Properly conducted audit or inspection evaluation of the pharmacovigilance system makes it possible to identify and prevent drug safety problems at all stages of its life cycle.The aim. Development of a risk-based strategy for planning and passing audits and inspections of the pharmacovigilance system for the subsequent creation of effective programs for assessing the pharmacovigilance system on its basis.Material and methods. The study used structurallogical, empirical methods, general logical methods of scientific knowledge, methods of generalization and extrapolation.Results. The plans and results of audits and inspections of pharmacovigilance systems of Russian and foreign pharmaceutical organizations and their pharmacovigilance vendors were analyzed. A risk-based strategy and a checklist for planning internal and external audits of pharmacovigilance systems of Russian pharmaceutical organizations and their vendors for pharmacovigilance have been developed and recommendations for training internal auditors of pharmacovigilance systems and audit teams have been developed for them.Conclusion. Risk assessment indicators adapted for Russia have been developed, according to which Russian pharmaceutical organizations and their pharmacovigilance vendors can assess the likelihood of the risk of priority inclusion in the plan of Russian inspections of pharmacovigilance systems for compliance with the requirements of the good pharmacovigilance practice of the Eurasian Economic Union. Recommendations were prepared for the executive management and pharmacovigilance specialists of Russian pharmaceutical organizations in terms of assessing regulatory risks for the quality system of the pharmacovigilance system, planning and conducting audits; evaluating the relationship of pharmacovigilance with other good practices and with information from the plans and results of the organization as a whole. The indicators adapted for Russia for assessing the compliance of the pharmacovigilance system with the rules of the NPF EAEU are given.