bluuebunny/crossref_metadata_2025_split huggingface dataset:
The living donor evaluation as a life‐saving event
Authors: Park Sun‐Cheol , Shapiro Ron , Good Deborah , Lopez Roberto , Shah Nirav , Sood Puneet , Sturdevant Mark , Tan Henkie , Vekasy Maureen , Wijkstrom Martin , Wu Christine , Humar Abhinav 
Published: December 2022

AbstractBackgroundAs a population, living kidney donors have a longer life expectancy than the general population. This is generally thought to be an artifact of selection, as only healthy individuals are allowed to donate, and the operative mortality and risk of subsequent renal failure are very low. However, there may also be an additional benefit to the process, as the donor evaluation may uncover an early occult cancer or a potentially serious medical problem. While these problems may preclude donation, they may be lifesaving, as they are likely to be diagnosed and treated before the donor develops symptoms.Patients and MethodsWe looked at the incidence of occult cancer and other previously undiagnosed medical problems including renal disease, diabetes, hypertension, cardiac disease, and hepatitis C, in individuals volunteering to become a kidney donor at our center who proceeded with the evaluation between January 1, 1996 and May 31, 2011.ResultsOf 4088 potential donors, 19 (.46%) were discovered to have an unsuspected cancer, and 286 (7%) were found to have a previously undiagnosed medical problem.ConclusionsThe living donor evaluation may lead to the early diagnosis of a life‐threatening illness. This should be considered as one of the potential benefits of living donation.
Involvement of hypoxia‐inducible factor activity in inevitable air‐exposure treatment upon differentiation in a three‐dimensional keratinocyte culture
Authors: Teshima Hirofumi , Endo Mayuko , Furuyama Yumea , Takama Hiroyuki , Akiyama Masashi , Tsuji Tokuji , Tatsukawa Hideki , Hitomi Kiyotaka 
Published: December 2022

Formation of the human skin epidermis can be reproduced by a three‐dimensional (3D) keratinocyte culture system, in which air‐exposure is inevitable upon initiation of differentiation. In the continuous submerged culture without air‐exposure, even with a differentiation‐compatible medium, several keratinocyte‐specific proteins were not induced resulting in the formation of aberrant epidermal layers. To clarify the mechanism by which air‐exposure promotes keratinocyte differentiation, we performed a comparative analysis on biological properties between submerged and air–liquid interphase culture systems. By transcriptomic analysis, hypoxia‐inducible factor (HIF)‐related genes appeared to significantly change in these cultured cells. In submerged culture, the transcriptional activity of HIF on its canonical response element was enhanced, while air‐exposure treatment drastically reduced the transcriptional activity despite the high HIF protein level. Regulating HIF activity through reagents and genetic manipulation revealed that the reduced but retained HIF‐transcriptional activity was essentially involved in differentiation. Furthermore, we showed, for the first time, that artificial supplementation of oxygen in the submerged culture system could restore keratinocyte differentiation as observed in the air‐exposed culture. Thus, we mechanistically evaluated how HIF regulates the air‐exposure‐dependent differentiation of keratinocytes in a 3D culture system.
Family Hubs and the vulnerable care ecologies of child and family welfare in austerity
Authors: Disney Tom , Crossley Steve , King Hannah , Phillips Josie , Robson Ian , Smith Roger 
Published: December 2022

AbstractThis article takes an ecological approach to examine the legacies of austerity for local authority welfare systems in England and the implications for families seeking to use these services. Programmes of Early Intervention or Early Help that promote ‘resilience’ amongst marginalised families and reduce future dependency upon state services have been advocated consistently in the UK, currently intensifying with a period of welfare retrenchment and restructuring. Many programmes and approaches being promoted prioritise a discourse of individual or familial responsibility and seek to deflect attention away from structural and environmental changes that have taken place. We explore local authority family and child support services as relational care practices that have been fundamentally reshaped through austerity, and in doing so we seek to shift the conversation from individual responsibility to systemic and collective vulnerabilities. Drawing on the concept of ‘care ecology’ to conceptualise local authority Early Help services as ‘carescapes’, we focus specifically on the changing context of ‘Family Hubs’, and the fragmented nature of service provision. As with any ecosystem, care ecologies are constituted by interconnected and interdependent actors, processes and systems. Damage to them produces unintended consequences which exacerbate underlying ‘vulnerabilities’. We explore this as a legacy of austerity, noting that this has resulted in forms of socio‐spatial distancing from care provision for families, disrupting protective networks and support systems. We argue that local authority support services would be better focused on systemic and collective vulnerabilities rather than individual responsibilities in order to provide meaningful support to families.
Potential of HMGB‐inhibitory oligodeoxynucleotide ISM ODN to neutrophil recruitment in mouse model of hepatitis
Authors: Inoue Asuka , Chiba Shiho , Eto Shotaro , Taniguchi Tadatsugu , Yanai Hideyuki 
Published: December 2022

AbstractHigh‐mobility group box 1 (HMGB1) is a nucleotide‐binding chromatin protein that has also been characterized as a prototypical damage‐associate molecular pattern. It triggers inflammatory responses upon release from damaged or dying cells. In fact, HMGB1 has been linked to the induction of many inflammatory diseases through immune cell activation including neutrophil recruitment. In this study, we examined the impact of HMGB1‐binding inhibitory oligodeoxynucleotide (ISM ODN) on the development of hepatitis using a murine model of the disease. Our results indicate that ISM ODN effectively suppresses pathological features of hepatitis, including neutrophil accumulation. This study therefore may offer clinical insight into the treatment of hepatitis and possibly other inflammatory diseases.
Effect of carbon nanotubes additives on mechanical properties of WC–6Co cemented carbide
Authors: Zhang Shunlin , Su Wuli , Sun Lan , Wang Jun 
Published: December 2022

AbstractIn order to increase the toughness of WC–6Co cemented carbide, different contents of carbon nanotubes (CNTs) were added to the WC–6Co alloy powder to prepare cemented carbide by low‐pressure sintering. The results showed that some of the CNTs were embedded between the grains of WC–6Co cemented carbide, which would hinder the growth of WC grain boundary, thus leading to grain refinement. In addition, CNTs inhibited the formation of decarbonized phase and guided the deflection and bridge of crack to hinder the crack extension. With the increase of CNTs content, the density increased at first and then decreased, and the transverse fracture strength increased at first and then decreased. When the content was 0.2 wt.%, the alloy had the best performance. The density of the alloy was 99.67%; the transverse fracture strength was up to 2937.5 MPa, which is about 100% higher than that of cemented carbide without CNTs. The fracture toughness was 9.84 MPa m1/2, and the hardness was 1924.8HV30.
Impact of phenolic extracts and potassium hydroxycitrate of Hibiscus sabdariffa on adipogenesis: a cellular study
Authors: Singh Manisha , Thrimawithana Thilini , Shukla Ravi , Brennan Charles Stephen , Adhikari Benu 
Published: December 2022

SummaryAdipogenesis is a complex physiological process involving the formation of adipocytes and accumulation as adipose tissues. It is one of the contributors for the development of obesity. This study assessed the potential of phenolic extracts and potassium hydroxycitrate, obtained from Hibiscus sabdariffa, to inhibit adipogenesis. The phenolic extracts were obtained using organic solvents (methanol, ethanol and ethyl acetate) and water individually. Human adipose‐derived stem cells (hADSCs) were selected to study the impact of these extracts on adipogenesis. Results showed that phenolic extracts were able to reduce lipid accumulation by about 95% in hADSCs, while potassium hydroxycitrate did not show any reduction. All the phenolic extracts downregulated the gene expression of two key adipogenic markers (PPAR‐γ and aP2). Ethanol extracts exhibited the highest downregulation of PPAR‐γ and aP2 by 3 and 10 times, respectively. There was no improvement in the anti‐adipogenic potential when the phenolic extract was combined with potassium hydroxycitrate confirming that phenolic compounds were responsible for the inhibition of adipogenesis. These results indicate that phenolic extracts from H. sabdariffa have potential to regulate the expression of adipogenic genes and restrict the lipid accumulation in mature adipocytes. Thus, phenolic extracts can be used in formulations intended to manage obesity.
Natural killer cells promote intra‐cellular‐infected trophoblasts survival via APOD‐LRP1 axis
Authors: Fang Xi , Zhou Yonggang , Chen Siao , Xu Xiuxiu , Ke Jieqi , Zhou Ying , Wei Haiming , Fu Binqing 
Published: December 2022

AbstractNatural killer (NK) cells are known for their potent ability to kill stressed cells, whereas host cells infected with intra‐cellular bacteria may also be benefit from the selective killing function of NK cells and survive. The mechanism of how NK cells protect host cells infected with intra‐cellular bacteria is still unclear. Here, we discovered that decidual NK (dNK) cells cannot only eliminate intra‐cellular bacteria which infected trophoblasts, but can also synthesize more lipids and transport lipids to trophoblasts to avoid their apoptosis. Mechanically, NK cells synthesize more lipids accompanied by increasing expression of apolipoprotein APOD. Lipids in NK cells can be delivered to trophoblast cells through APOD, maintaining adequate lipid droplet content and lipid metabolism homeostasis in trophoblasts. Blocking the APOD receptor LRP1 abolished lipid transport from NK cells to trophoblasts, and the reduction of lipid droplets caused by bacterial infection in trophoblast cells could not be restored, culminating in cell apoptosis. Our study provides new evidence for the immune surveillance and protective effect of NK cells on embryos during early pregnancy.
Study of recovery model implementation in psychiatric hospitals: Clients and multidisciplinary staff perspective
Authors: Biran‐Ovadia Ateret , Strous Rael D. , Bart Orit , Lipskaya‐Velikovsky Lena 
Published: December 2022

AbstractThe recovery model guides mental health services. However, the delivery of recovery‐oriented services in inpatient settings is still a challenge. Factors affecting recovery model implementation can be classified into three types: the hospital environment, the inpatient and the service provider. This study aims to quantitatively evaluate the impact of environment, inpatient and service provider factors on recovery model implementation in hospitals. Forty‐five service providers and 42 inpatients from three types of wards (acute locked, acute open and daycare) of two hospitals participated in this cross‐sectional study. We assessed inpatient cognition, functional capacity and illness severity. In addition, we retrieved information on service providers' professional status and evaluated the recovery model knowledge and attitudes. Implementation of the recovery model was measured using the Recovery Self‐Assessment, both the inpatient and service provider versions. Differences were found between the three types of wards in recovery orientation as reported by service providers ( = 15.3, P < 0.001), but not by inpatients ( = 2.34, P > 0.05). Providers' internalized knowledge and attitudes toward recovery, inpatients' functional capacity and age of illness onset were associated with recovery implementation (0.31 < r < 0.48, P < 0.05). The findings confirm quantitatively the multilevel nature of factors that affect the implementation of the recovery model in psychiatric hospitals. The inpatients' perspective should be incorporated into the service development process. Based on the study results, the reduction in the restrictive features of the wards' environment is recommended. Promotion of the recovery model implementation in the hospital setting requires the expansion of staff's internal positive attitudes toward recovery.
Novice nurses' experiences in provision of mental ill health care within a regional emergency department: A descriptive qualitative study
Authors: Peart Talitha , Kerr Debra , Searby Adam 
Published: December 2022

AbstractEmergency departments are often the first point of contact for individuals presenting to healthcare services for assistance and treatment for mental ill health. Emergency departments, particularly those in regional areas, can experience high staff turnover and rely on novice nurses for workforce sustainability. The aim of this paper is to explore the experiences of novice nurses (nurses with <3 years of experience) in providing care to individuals presenting with mental ill health in the emergency department. Semi‐structured interviews were conducted with novice nurses (N = 13) in a regional emergency department, using qualitative description as the guiding framework. The following three main themes were identified: (i) confidence in providing quality and safe nursing care, (ii) perceived barriers to providing quality and safe nursing care, and (iii) factors that increase confidence. Our findings indicate that proving safe and appropriate nursing care is affected in novice nurses by factors that lead to a perceived lack of confidence, such as how individuals present to the emergency department (e.g. intoxicated or violent), an inability to conduct conversations to assess accurately and perceived shortfalls in the emergency department environment itself. Future research should examine the curriculum for relevance of undergraduate education regarding acute mental health presentations and develop training strategies that enhance communication with individuals who present to the emergency department with mental ill health.
Ink development for the additive manufacturing of strong green parts by layerwise slurry deposition (LSD‐print)
Authors: Diener Sarah , Schubert Hendrik , Günster Jens , Zocca Andrea 
Published: December 2022

AbstractObtaining dense fine ceramics by the binder jetting additive manufacturing process is challenging. A slurry‐based binder jetting process, such as the layerwise slurry deposition (LSD‐print) process, can enable the printing of dense ceramic parts. This work describes a procedure to develop and qualify a suitable ink to manufacture silicon carbide green parts by LSD‐print. Not only the printability but also the compatibility of the ink with the powder bed and the effect of the binding agent on the properties of the green parts are considered. Both aspects are important to obtain high green strength, which is necessary for printing large or thin‐walled parts. Characterization methods, such as rheological and surface tension measurements, are applied to optimize three selected inks. The interplay between ink and powder bed is tested by contact angle measurements and by comparing the biaxial strength of cast and additively manufactured specimens. Out of the three binding agents tested, a polyethyleneimine and a phenolic resin have a high potential for their use in the LSD‐print of silicon carbide green bodies, whereas a polyacrylate binding agent did not show the required properties.
Experiences of people with intellectual disability and dementia: A systematic review
Authors: Jacobs Paula , Watchman Karen , Wilkinson Heather , Hoyle Louise , McGenily Laura 
Published: December 2022

AbstractBackgroundDementia disproportionately affects people with intellectual disability. Most qualitative studies explore their experiences by utilising proxy‐reports. A smaller number of studies illustrate the possibility of exploring perspectives directly from people with intellectual disability and dementia.MethodThis systematic review synthesised findings from existing studies (n = 8) that involve people with intellectual disability and dementia as participants to understand their experiences of dementia. Searches were conducted using CINAHL, PsychInfo and Social Services Abstracts.ResultsFindings include descriptions of changes in individual functioning, a narrowing of social worlds and of how people made sense of the changes despite often having no knowledge of their dementia diagnosis. Additionally, discussion focuses on how people's experiences are shaped by their environments.ConclusionThe review recognises the complexities of speaking to people with intellectual disability about dementia, challenges views that people with intellectual and dementia cannot be involved in research and makes recommendations to support inclusion in future studies.
Peace, Prosperity and Protection: Narratives of Integration and the ‘Justification Jungle’ of Europe's Public Spheres
Authors: de Wilde Pieter 
Published: December 2022

AbstractThe European Union (EU) is in search of a new narrative to create a sense of common purpose, but it is unclear around which values that narrative should be built. To analyse how different narratives resonate in Europe's public spheres, this article presents a novel dataset based on claims analysis of newspaper articles from Germany, France, Italy, Spain, Poland and Denmark between 2012 and 2019 on the issues of migration, the Economic and Monetary Union (EMU), trade and counterterrorism. Descriptive and logistic regression analyses show how different frames have been used for various policy agendas. This reveals considerable variation, but comparatively low levels of explained variance. Europe's public spheres can thus be described as a ‘justification jungle’, where many actors use a range of arguments to back up diverging political demands. This poses a formidable obstacle to any single narrative of European integration.
Attentional biases for sad faces in offspring of mothers with a history of major depression: trajectories of change from childhood to adolescence
Authors: Gibb Brandon E. , Owens Max , Brick Leslie A. D. 
Published: December 2022

BackgroundTheorists have proposed that the way children process social–emotional information may serve as a mechanism of risk for the intergenerational transmission of depression. There is growing evidence that infants and children of mothers with a history of major depressive disorder (MDD) during the child's life exhibit attentional avoidance of sad faces, which has been proposed as an early emerging emotion regulation strategy. In contrast, there is clear evidence that at‐risk and depressed adolescents and adults exhibit difficulty disengaging attention from sad faces.MethodsSeeking to link these two literatures, the current U.S.‐based study used eye tracking within the context of an accelerated longitudinal design to assess attentional biases in 8–14‐year‐old offspring of mothers with a history MDD during the child's life (n = 123) or no history of MDD (n = 119) every six months for two years, allowing us to map trajectories of attention from age 8 to 16.ResultsMother MDD history moderated age‐based changes in children's gaze duration to sad (t[240] = 2.44, p = .02), but not happy (t[240] = 0.11, p = .91) or angry (t[240] = 0.67, p = .50), faces. Consistent our hypotheses, offspring of mothers with MDD exhibited significantly less attention to sad faces than offspring of never depressed mothers before age 8.5 but significantly more attention to sad faces after age 14.5, which was due to an increase in gaze duration to sad faces from childhood to adolescence among offspring of mothers with MDD (t[122] = 5.44, p < .001) but not among offspring of never depressed mothers (t[118] = 1.49, p = .14).ConclusionsIt appears that the form, and perhaps function, of attentional bias may shift across development in at‐risk youth. To the extent that this is true, it has significant implications not only for theories of the intergenerational transmission of depression risk but also for prevention and early intervention efforts designed to reduce this risk.
Commentary: The roles of mothers versus fathers in intergenerational family risk – a commentary on Rothenberg et al. (2023)
Authors: Capaldi Deborah M. , Kerr David C.R. 
Published: December 2022

Basic research studies in the past 2 decades have established that conduct problems and antisocial behavior are associated across generations within families. The Fast Track study represents a major prevention effort with children showing higher levels of conduct problems in childhood, and the Rothenberg et al. (Journal of Child Psychology and Psychiatry, 2022) study sheds light on whether this intervention has beneficial effects on the family of procreation. In this commentary, we consider the implications of the major finding that such effects were found for women but not for men. We discuss evidence that men's parenting behavior is influenced by the parenting behavior and overall risk of their women partners, and thus preventive interventions in childhood may have beneficial influences on fathers through mothers.
Blocking interleukin‐17 in psoriasis: Real‐world experience from the PsoPlus cohort
Authors: Schots Lisa , Soenen Rani , Blanquart Brigitte , Thomas Debby , Lambert Jo 
Published: December 2022

AbstractBackgroundReal‐world studies on the use of biologics in psoriasis (Pso) are increasing, but still scarce. Trough concentrations (Cts) of interleukin‐17 inhibitors (IL‐17i) seem promising for clinical decision‐making, but their value in daily practice has yet to be proven.ObjectivesTo report on IL‐17i effectiveness, treatment modifications and Ct use in our clinic.MethodsData were collected from IL‐17i‐treated Pso patients followed up in the PsoPlus clinic at the Dermatology department, Ghent University Hospital, Belgium. Descriptive statistics and Kaplan–Meier analysis were performed.ResultsA total of 111 patients were included, counting for 134 IL‐17i courses (secukinumab, ixekizumab, and brodalumab). Fifty‐five per cent of the patients were bio‐naive prior to IL‐17i initiation. During maintenance, merely 97.0% and 77% achieved near‐complete and complete skin clearance, respectively. Major reasons for treatment modification were suboptimal response (63.0%) and safety issues (9.3%). Reported modifications were switch (25.4%), dose escalation (11.9%), dose de‐escalation (6.7%), treatment association (6.0%) and IL‐17i stop (3.0%). Overall drug survival was 69.0 months, without difference between the different IL‐17i (p = 0.078). Ixekizumab tended to have the highest survival. Drug survival was higher in bio‐naive subjects compared to bio‐experienced subjects (p = 0.011). Ct was measured in 20 patients and interpreted post hoc. In 85%, the clinical decision was in accordance with the Ct (e.g. substantiated need for dose escalation). For the other cases, the Ct would have led to another clinical decision if known at that time.ConclusionsThis real‐world study showed that IL‐17i are very effective drugs for Pso, with ixekizumab as leading biologic. Prior bio‐experience seemed to impact IL‐17i drug survival. Treatment modifications were mainly performed in case of insufficient response, primarily via switch and dose escalation, and least frequently in ixekizumab patients. Ct might rationalize clinical decision‐making; however, there is need for standardized algorithms to corroborate its use.