bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward a low‐carbon and circular building sector: Building strategies and urbanization pathways for the Netherlands
Authors: van Oorschot Janneke , Sprecher Benjamin , Rijken Bart , Witteveen Pieter , Blok Merlijn , Schouten Nico , van der Voet Ester 
Published: January 2023

AbstractBuildings are an important part of society's environmental impacts, both in the construction and in the use phase. As the energy performance of buildings improve, construction materials become more important as a cause of environmental impact. Less attention has been given to those materials. We explore, as an alternative for conventional buildings, the use of biobased materials and circular building practices. In addition to building design, we analyze the effect of urbanization. We assess the potential to close material cycles together with the material related impact, between 2018 and 2050 in the Netherlands. Our results show a limited potential to close material cycles until 2050, as a result of slow stock turnover and growth of the building stock. At present, end‐of‐life recycling rates are low, further limiting circularity. Primary material demand can be lowered when shifting toward biobased or circular construction. This shift also reduces material related carbon emissions. Large‐scale implementation of biobased construction, however, drastically increases land area required for wood production. Material demand differs strongly spatially and depends on the degree of urbanization. Urbanization results in higher building replacement rates, but constructed dwellings are generally small compared to scenarios with more rural developments. The approach presented in this work can be used to analyze strategies aimed at closing material cycles in the building sector and lowering buildings' embodied environmental impact, at different spatial scales.
Tranexamic acid in melasma: A focused review on drug administration routes
Authors: Konisky Hailey , Balazic Eliza , Jaller Jose A. , Khanna Urmi , Kobets Kseniya 
Published: January 2023

AbstractBackgroundMelasma is a disorder of hyperpigmentation and vascularization often found in women between the ages of 20 and 40. The pathogenesis is unknown, but melasma often occurs in sun‐exposed areas of the face, forearms, and back. Risk factors include family history, increased estrogen/progesterone, certain medications, and UV exposure. Melasma is typically treated with topical hydroquinone (HQ); however, it is often refractory to treatment. Tranexamic acid (TXA) is a plasmin inhibitor used off‐label in the treatment of melasma. TXA can be administered orally, topically, or intralesionally.AimsThe purpose of this review is to characterize the wide variety of TXA delivery methods for melasma treatment and the efficacy of these methods compared with traditional treatments.Patients/MethodsA comprehensive PubMed and Embase search was conducted in May 2022 using the phrases tranexamic acid and melasma. Forty‐six articles were included in this review.ResultsOral, intralesional, and topical TXA is safe and effective treatments for melasma. They have been studied in a variety of randomized controlled trials and have been compared with several traditional treatments. Overall, MASI scores in patients using TXA in any form improved.ConclusionsOral TXA was found to be the most effective, especially in cases of refractory melasma; however, it caused GI upset and menstrual irregularities in many patients. The pro‐thrombotic nature of this drug must be considered before safely prescribing to patients. Intralesional injections and microneedling with topical TXA were found to be effective alternatives to oral treatment. Lastly, topical TXA alone was found to be the least effective method but can be combined with other cosmeceuticals to improve outcomes. Topical TXA was also found to be better tolerated than hydroquinone, a traditional topical melasma treatment.
Alopecia areata and pattern hair loss (androgenetic alopecia) on social media – Current public interest trends and cross‐sectional analysis of YouTube and TikTok contents
Authors: Gupta Aditya K. , Polla Ravi Shruthi , Wang Tong 
Published: January 2023

AbstractBackgroundWith an ever‐growing influence of social media in healthcare, concurrent with increased emphasis on patient autonomy and shared decision‐making, dermatologists treating hair loss need to be cognizant of online interest trends and the types of information disseminated across popular platforms.ObjectivesTo evaluate recent health‐related interest trends and assess engagement, quality, and accuracy of alopecia areata (AA) and pattern hair loss (PHL, androgenetic alopecia) contents on social media.MethodsRelative search volumes (RSVs) were extracted from Google Trends using the search category ‘alopecia areata’ and ‘pattern hair loss’. Eighty matching videos on TikTok and YouTube were also extracted and characterized. Viewer engagement was estimated using the engagement ratio, and quality and accuracy were assessed using DISCERN and Dy et al. Accuracy Scale (DAS).ConclusionsAA‐related contents on TikTok discussing personal experiences of female subjects were significantly more engaging. DISCERN and DAS scoring showed significantly higher quality and accuracy in videos created by healthcare providers on YouTube, but not TikTok, which could in part be related to YouTube videos being longer. RSV fluctuations corresponding to news in popular culture had high impact. Sponsorship disclosures were generally not reported in product promotional videos.
13CO2 labelling as a tool for elucidating the mechanism of cuticle development: a case of Clusia rosea
Authors: Kubásek Jiří , Kalistová Tereza , Janová Jitka , Askanbayeva Balzhan , Bednář Jan , Šantrůček Jiří 
Published: January 2023

Summary

The plant cuticle is an important plant‐atmosphere boundary, the synthesis and maintenance of which represents a significant metabolic cost. Only limited information regarding cuticle dynamics is available.

We determined the composition and dynamics of Clusia rosea cuticular waxes and matrix using 13CO2 labelling, compound‐specific and bulk isotope ratio mass spectrometry. Collodion was used for wax collection; gas exchange techniques to test for any collodion effects on living leaves.

Cutin matrix (MX) area density did not vary between young and mature leaves and between leaf sides. Only young leaves incorporated new carbon into their MX. Collodion‐based sampling discriminated between epicuticular (EW) and intracuticular wax (IW) effectively. Epicuticular differed in composition from IW. The newly synthetised wax was deposited in IW first and later in EW. Both young and mature leaves synthetised IW and EW. The faster dynamics in young leaves were due to lower wax coverage, not a faster synthesis rate. Longer‐chain alkanes were deposited preferentially on the abaxial, stomatous leaf side, producing differences between leaf sides in wax composition.

We introduce a new, sensitive isotope labelling method and demonstrate that cuticular wax is renewed during leaf ontogeny of C. rosea. We discuss the ecophysiological significance of the new insights.
The temporal and spatial dimensions of plant–soil feedbacks
Authors: Chung Y. Anny 
Published: January 2023

SummaryFeedbacks between plants and soil microbes form a keystone to terrestrial community and ecosystem dynamics. Recent advances in dissecting the spatial and temporal dynamics of plant–soil feedbacks (PSFs) have challenged longstanding assumptions of spatially well‐mixed microbial communities and exceedingly fast microbial assembly dynamics relative to plant lifespans. Instead, PSFs emerge from interactions that are inherently mismatched in spatial and temporal scales, and explicitly considering these spatial and temporal dynamics is crucial to understanding the contribution of PSFs to foundational ecological patterns. I propose a synthetic spatiotemporal framework for future research that pairs experimental and modeling approaches grounded in mechanism to improve predictability and generalizability of PSFs.
Pilot longitudinal kidney transplant transition program promotes peer connections and transition readiness
Authors: Caron Rachel , Richardson Kelsey L 
Published: January 2023

AbstractBackgroundAdolescents who have received a kidney transplant are at high risk of graft rejection and transplant‐related comorbidities around the time of transition from pediatric to adult care. While there has been a progress in tracking transition readiness, further work is needed to prepare adolescents for healthcare transitions. We describe a longitudinal cohort‐based transition curriculum designed to prepare kidney transplant recipients for adult transplant care.MethodsAdolescent kidney transplant recipients aged 17 and older participated in the pilot cohort of the 2‐year transition curriculum. Session topics included communication with the healthcare team, insurance, job skills, reflective practice, reproductive health, medications, and adult clinic introduction. Surveys were given to obtain narrative feedback, assess participant self‐management behavior, and track curriculum knowledge.ResultsEach participant attended an average of two sessions, with 18 out of 30 eligible adolescents participating in at least one session. After transitioning to a virtual platform, there was increased attendance of participants who live greater than 150 miles from the transplant center. Adolescents highlighted the value of the program's group structure to relate to and learn from other participants.ConclusionsThe pilot transition program successfully provided adolescent kidney transplant recipients the opportunity to learn alongside their peers and gain interdisciplinary knowledge to prepare for healthcare transition. The program converted to a virtual platform during the COVID‐19 pandemic, with increased accessibility for participants who live further from the transplant center. Group‐based programming for adolescents should be enhanced to further prepare them for transitions to adult medicine.
The response of high density turbidity currents and their deposits to an abrupt channel termination at a slope break: Implications for channel–lobe transition zones
Authors: Wilkin Jonathan , Cuthbertson Alan , Dawson Sue , Stow Dorrik , Stephen Karl , Nicholson Uisdean , Penna Nadia 
Published: January 2023

ABSTRACTThe transition between the slope and basin floor is typically marked by a slope break, in some cases causing channels to terminate and turbidity currents to undergo a loss of confinement. It is thus essential to understand how these slope breaks and losses of confinement influence the hydrodynamic evolution of turbidity currents and impact their depositional variability within natural scale channel mouth settings. Flume experiments, utilizing Shields scaling, are conducted to study how channel slope angle (3°, 6° and 9°) and initial suspended sediment concentrations (12 to 18% by volume) impact the hydrodynamics and deposit geometries of high density turbidity currents, subject to a simultaneous break of slope and loss of confinement. Measured velocity and concentration profiles indicate that turbidity currents are supercritical, with mean velocities between 0.80 m s−1 and 1.04 m s−1 and depth‐averaged basal concentrations between 9.2% and 23.9%, yielding bed shear velocities between 0.050 m s−1 and 0.064 m s−1. Upon encountering the slope break and loss of confinement, turbidity currents exhibit increases to their densimetric Froude numbers and shear velocities. This is due primarily to two factors: firstly, turbidity currents continue to accelerate during an initial period of velocity lag as their residual momentum gradually dissipates; and, secondly, expansion via flow relaxation collapses their structure towards the bed. The corresponding depositional geometries of these processes reveal that turbidity currents produce elongate channel–lobe transition zones that disconnect channel and basin deposits. The length to width ratios of channel–lobe transition zones decrease as the initial sediment concentrations of turbidity currents increase, while a reduction in the channel slope break angle reduces their length to width ratios. Corresponding, lobe elements are observed to increase in length, width and thickness with increasing initial sediment concentrations, while a reduction in channel slope break angle reduces their dimensions due to enhanced slope deposition.
A global examination of clinical ladder programs – A synthesis of commonalities and opportunities for standardization
Authors: Slagle Amanda , Wakim Nada , Gray Sarah E. 
Published: January 2023

AbstractBackgroundClinical ladder programs (CLPs) have been part of the nursing profession for nearly 4 decades. However, the structure and implementation of CLPs vary widely throughout healthcare systems. CLPs are a valuable factor in nurse retention and employee satisfaction initiatives, but globally replicating and measuring their impact is difficult due to lack of standardization.AimTo identify opportunities for global standardization of CLPs through a systematic review of published evidence and facility‐sourced CLPs applications and program documents.MethodThis study used a systematic literature search and scan of existing programs from facilities within the United States (US), Lebanon, and Ghana obtained through professional ties and organizational membership.ResultsSeventy‐nine articles were screened with 30 studies identified for inclusion, plus 20 CLPs from the US and international facilities. Identified commonalities were the lack of consistency in the number of clinical levels across the CLPs, eligibility requirements and application process, reward and recognition, lack of emphasis on technology and informatics, and missed opportunities to use CLPs to drive a culture of safety. The administrative burden of the programs and the time required by the nurse to complete the CLP application were rarely referenced.Linking Evidence to ActionThe lack of consistency between facilities and across the healthcare sectors limits the measurable impact CLPs have on the nursing profession. Recommendations for practice include developing a standardized professional development framework. A standardized framework will encourage adoption of a retention tool that will provide the profession with a measurable method to demonstrate the value it brings to patient care. Providing guidance to health care facilities in low‐ and middle‐income countries on the implementation of a professional development framework will assist in closing the global gap of professional development opportunities for nurses.
Leveraging the South African Diabetes Prevention Programme to screen for chronic kidney disease: an observational study
Authors: George Cindy , Hill Jillian , Nqebelele Unati , Peer Nasheeta , Kengne Andre P 
Published: January 2023

ObjectiveTo evaluate the viability of leveraging an existing screening programme (the South African Diabetes Prevention Programme (SA-DPP)) to screen for chronic kidney disease (CKD), by assessing the yield of CKD cases among those participating in the programme.DesignObservational study conducted between 2017 and 2019.Setting16 resource–poor communities in Cape Town, South Africa.Participants690 participants, aged between 25 and 65 years, identified as at high risk for type 2 diabetes mellitus (T2DM) by the African Diabetes Risk Score.Primary outcome measureThe prevalence of CKD among those participating in the SA-DPP.ResultsOf the 2173 individuals screened in the community, 690 participants underwent further testing. Of these participants, 9.6% (n=66) and 18.1% (n=125) had screen-detected T2DM and CKD (defined as an estimated glomerular filtration rate (eGFR) of<60 mL/min/1.73 m2and/or albumin-to-creatinine ratio >3 mg/mmol), respectively. Of those with CKD, 73.6% (n=92), 17.6% (n=22) and 8.8% (n=11) presented with stages 1, 2 and 3, respectively. Of the participants with an eGFR <60 mL/min/1.73 m2, 36.4% had no albuminuria and of those with normal kidney function (eGFR ≥90 mL/min/1.73 m2), 10.2% and 3.8% had albuminuria stages 2 and 3, respectively. Of those with T2DM and hypertension, 22.7% and 19.8% had CKD, respectively.ConclusionThe fact that almost one in five participants identified as high risk for T2DM had CKD underscores the value of including markers of kidney function in an existing screening programme. By using an opportunistic approach to screen high-risk individuals, those with CKD can be identified and appropriately treated to reduce disease progression.
Oesophageal squamous papilloma in paediatric population: a single-centre case series
Authors: Hernández-Almeida Pamela , Vásconez-Muñoz Fabián , Vásconez-Montalvo Andrea , Montalvo-Flores Nelson , Redrobán-Armendariz Ligia , Aymacaña-Albán Edison 
Published: January 2023

PurposeOesophageal squamous papilloma (OSP) is a rare epithelial lesion with an unclear aetiology, found incidentally in upper gastrointestinal endoscopy (UGE). We evaluate the epidemiology, general features and endoscopic and histological characteristics of OSP in children in a single centre.MethodsWe conducted a retrospective search of 3568 medical records of children under 18 years old who underwent UGE between 2004 and 2022, at Hospital Metropolitano de Quito, Ecuador. We described the general features of 15 patients diagnosed with OSP. Histopathology reports were analysed, including a chromogenic in situ hybridisation (CISH) for human papillomavirus (HPV) 6/11.ResultsOSP was diagnosed in 15 patients between 10 and 16 years of age, with an estimated prevalence of 0.4%. The gender ratio male to female was 1:1.1. Most patients (n=14) underwent UGE due to abdominal pain. Lesions were found predominantly in the upper and lower part of the oesophagus; 12 patients had isolated lesions, and none of the lesions tested positive for HPV on CISH 6/11 analysis. Additionally,Helicobacter pyloriand eosinophilic oesophagitis (EoE) were diagnosed in one patient each.ConclusionOur study describes the clinical features of paediatric OSP in a single centre. The prevalence was similar to that in the adult population but higher than in other paediatric populations, and none of our patients had HPV.
Impact of atrial fibrillation on the treatment effect of bridging thrombolysis in ischemic stroke patients undergoing endovascular thrombectomy: a multicenter international cohort study
Authors: Loo Jing Hong , Leow Aloysius ST , Jing Mingxue , Sia Ching-Hui , Chan Bernard PL , Seet Raymond CS , Teoh Hock-Luen , Meyer Lukas , Fiehler Jens , Papanagiotou Panagiotis , Kastrup Andreas , Mpotsaris Anastasios , Maus Volker , Yapici Furkan , Simonato Davide , Gabrieli Joseph D , Cester Giacomo , Bhogal Pervinder , Spooner Oliver , Nikola Christos , Joshi Abhishek , Lee Tsong-Hai , Wu Jiale , Chen Yimin , Yang Shuiquan , Sharma Vijay Kumar , Tan Benjamin YQ , Yeo Leonard LL 
Published: January 2023

BackgroundThe role of bridging intravenous thrombolysis (IVT) before endovascular thrombectomy (EVT) in the treatment of acute ischemic stroke (AIS) remains debatable. Atrial fibrillation (AF) associated strokes may be associated with reduced treatment effect from IVT. This study compares the effect of bridging IVT in AF and non-AF patients.MethodsThis retrospective cohort study comprised anterior circulation large vessel occlusion (LVO) AIS patients receiving EVT alone or bridging IVT plus EVT within 6 hours of symptom onset. Primary outcome was good functional outcome defined as modified Rankin Scale (mRS) 0–2 at 90 days. Secondary outcomes were successful reperfusion defined as expanded Thrombolysis In Cerebral Infarction (eTICI) grading ≥2b flow, symptomatic intracerebral hemorrhage (sICH), and in-hospital mortality.ResultsWe included 705 patients (314 AF and 391 non-AF patients). The mean age was 68.6 years and 53.9% were male. The odds of good functional outcomes with bridging IVT was higher in the non-AF (adjusted odds ratio (aOR) 2.28, 95% CI 1.06 to 4.91, P=0.035) compared with the AF subgroups (aOR 1.89, 95% CI 0.89 to 4.01, P=0.097). However, this did not constitute a significant effect modification by the presence of AF on bridging IVT (interaction aOR 0.12, 95% CI −1.94 to 2.18, P=0.455). The rate of successful reperfusion, sICH, and mortality were similar between bridging IVT and EVT for both AF and non-AF patients.ConclusionThe presence of AF did not modify the treatment effect of bridging IVT. Further individual patient data meta-analysis of randomized trials may shed light on the comparative efficacy of bridging IVT in AF versus non-AF LVO strokes.
Bridging the Gap – A Traffic Light System to Ease Communication Amongst Surgeons, Hand Therapists and Patients
Authors: PAI Ashwin Alke , MAHESHWARI Kavish , HINDOCHA Sandip 
Published: January 2023

Communication in the healthcare setup is essential for patient safety and for seamless delivery of services to the patient. We have adopted a novel way of communication in the form of a colour-coded visual aid in the form of a traffic light system to guide the patients through the course of their treatment. This shows the treatment plan in the form of Red, Amber, Green and Blue. The Red (Stop) denotes complete immobilisation with Splints, Amber (Proceed with caution) denotes active movements only, Green (Go forward) denotes Passive and Active movements and Blue shows when the patient can undergo guided weight bearing and strengthening exercises without a splint. The implementation of this system has created a streamlining of our protocol and improvement in the quality of the care we deliver. Level of Evidence: Level V (Therapeutic)
Vegetational change during the Middle–Late Pennsylvanian transition in western Pangaea
Authors: Schachat Sandra , Baresch Andrés , Bui Thu , Falcon-Lang Howard J. , Chaney Dan S. , Nelson W. John , Elrick Scott D. , Kerp Hans , Lucas Spencer G. , DiMichele William A. 
Published: January 2023

Abstract
We present the first analysis of vegetational change in far western equatorial Pangaea (New Mexico, USA) during the Middle–Late Pennsylvanian transition (determined by conodonts and fusulinids) of the Late Paleozoic Ice Age. The study is based on the largest database assembled from this region: 28 of 44 quantitatively analysed floras from 14 of 26 stratigraphic levels. Most sampled floras are ‘mixed’, both below and above the boundary, including both hygromorphic and mesomorphic/xeromorphic taxa. The taxonomic data were recalibrated morphometrically focusing on foliar traits of lamina width and venation. All data were examined using stratigraphic credible intervals, capture–mark–recapture analyses, and resampling analyses. Results indicate no substantive taxonomic turnover across the boundary. This stands in marked contrast to patterns in mid-Pangaean coal basins where there is a large wetland vegetational turnover. However, plant and physical geological data indicate that immediately following the boundary in New Mexico, and for approximately half of the Missourian Stage, floras previously dominated by hygromorphs become overwhelmingly dominated by mesomorphic/xeromorphic taxa. Although expressed differently, the western Pangaean physical and palaeobotanical patterns parallel those from mid-Pangaean coal basins and suggest a widespread environmental change.