bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of commercial whitening toothpaste containing hydrogen peroxide and citric acid on dentin abrasion and erosion
Authors: Kim Jae-Heon , Kim Soyeon , Park Young-Seok 
Published: April 2023

Abstract

Background:Hydrogen peroxide (HP) and citric acid (CA), key contributors to toothpaste acidity, can lead to dental loss. This study is to compare the amount and pattern of abrasion or loss of dentin based on pH, buffering, and concentration of HP and CA in various commercial and experimental toothpastes after toothbrushing or immersion.Methods:Bovine dentin specimens were randomly assigned to nine solutions. The prepared solutions included two commercial toothpastes (whitening toothpaste [WT] with HP and CA; conventional toothpaste [CT] without HP and CA), reference slurry (RS), two CA solutions (0.1 M, CAS1; 0.00005 M, CAS2), basic solution (0.2 M sodium phosphate dibasic [SPDS]), CA phosphate buffer solution (0.1 M SPDS and 0.05 M CA [CAPB]), HP solution (1.33 M; HPS), and distilled water (DW). After 10,000 brushings and immersion for 1 h, the amount of dentin loss and surface pattern were measured and observed using noncontact profilometry. Data were analyzed using an analysis of variance and the Tukey test as a post hoc analysis (p<0.05).Results:WT with pH 5.0 had lower dentin abrasion than CT and RS after brushing but had higher dentin loss than both after immersion. While WT, CAS1, and CAPB surfaces exhibited comparable U-shaped patterns after brushing or immersion, a wedge shape was observed on CT and RS surfaces after brushing, with their surface patterns remaining intact after immersion. In addition, dentin abrasion, loss, and surface patterns of CAS2 and HPS, which had a pH of 5.0 like WT, did not significantly differ from those of DW after brushing and immersion.Conclusions:After brushing or immersion, the CA concentration may affect the erosive pattern on the dentin surface more than the HP concentration included in WT. The amount of abrasion or loss of dentin after brushing or soaking can vary based on the composition, concentration, and buffer in the solution, even if the pH levels are similar. With or without pH buffering, prolonged use of WT containing HP and high CA concentrations may cause further dentin damage beyond simple brushing.
Biochar Induced Chilies Cultivar Specific Defense Response Characterization Against Ralstonia solanaceraum
Authors: Abbas Muhammad Taqqi , Anjum Tehmina , Anwar Waheed , Khurshid Muhammad , Akhter Adnan 
Published: April 2023

Abstract
Background and Aims Biochar are considered to have the potential for managing plant diseases by activating plant defense pathways along with their role in influencing the soil-plant-microbe interactions outcome. Therefore, in this study we assessed the soil biochar amendments against bacterial wilt of chilies (Ralstonia solanacearum). Chilies cultivar specific response towards biochar was characterized with reference to physiological and biochemical alterations of the plants.Methods In this study we used the biochar prepared from leaf waste (LWB) of Syzygium cumini. The biochar was applied as a soil amendment at varied concentrations (3 and 6%, each) along with compost (20%) and the plants either inoculated with Ralstonia solanacearum or remained un-inoculated.Results All chilli (Capsicum annumm L.) cultivars [(V1 (F1 Zenia), V2 (Desi Chilli) and V3 (F1 green queen)] showed a positive influence of biochar amendment on plant growth even under bacterial induced wilt stress. Although, the reduction in percentage disease index (PDI) and disease incidence (DI) was significant for all cultivars in biochar amended treatments but resistance plant response against wilt was only recorded in cultivar V3 with 6% biochar. The chilies response to biochar was not only dependent upon the concentration of biochar applied but also on the biochemical alterations of the cultivars used.Conclusion Different chilli cultivars have shown varied levels of defense response activation in response to soil biochar amendment. These findings will certainly add to our existing understanding of biochar induced plant resistance activation as well as cultivar specific chilies defense response against R. solanacearum.
Existential gratitude and existential values predict Sense of Coherence; promoting health from an existential foundation.
Authors: Bernabe-Valero Gloria , Martínez-Cortés José Vicente , Moret-Tatay Carmen , Pelacho-Ríos Lucía 
Published: April 2023

Abstract

Background The health promotion strategies are directing their field of action to more profound actions involving personal change. A extensively researched and promising construct is known as Sense of coherence (SOC) which represents the orientation to salutogenic life. Investigations that provide empirical evidence are required to understand the fundamental predictors of salutogenic development. Until now, little attention has been paid in the scientific literature to the role of existential attitudes in the prediction of salutogenic variables. This paper relates the values included in Schwartz's model with gratitude viewed in terms of an existential attitude in this way filling a gap found in the previous literature.Method Correlational analyses between existential gratitude, gratitude as an affective disposition, values and SOC were conducted among 229 participants. In a Path Analysis, the values of Benevolence and Tradition and existential gratitude were chosen as predictors of SOC.Results Existential gratitude obtained significant correlations with all values and its scores were higher than the correlations between dispositional gratitude and values. The results of the Path analysis show good fit indices, indicating that SOC can be predicted by existential gratitude as well as by the values of benevolence and tradition.Conclusions The results are discussed in the light of the possibilities that this study opens up in the field of salutogenesis, based on the approach of the second wave positive psychology (PP2.0) which emphasizes the positive psychology of suffering since it takes into consideration the importance of conceptualizing Gratitude as an Existential attitude.
In vivo toxicity evaluation of a polyoxotungstate nanocluster as a promising contrast agent for computed tomography
Authors: Stojanović Marko , Lalatović Jovana , Milosavljević Aleksandra , Savić Nada , Simms Charlotte , Radosavljević Branimir , Ćetković Mila , Kravić-Stevović Tamara , Mrda Davor , Čolović Mirjana B. , Parac-Vogt Tatjana N. , Krstić Danijela 
Published: April 2023

Abstract
In this study, we demonstrate for the first time, that a discrete metal-oxo cluster α-/β-K6P2W18O62 (WD-POM) exhibits superior performance as a computed tomography (CT) contrast agent, in comparison to the standard contrast agent iohexol. A toxicity evaluation of WD-POM was performed according to standard toxicological protocols using Wistar albino rats. The maximum tolerable dose (MTD) of 2000 mg/kg was initially determined after oral WD-POM application. The acute intravenous toxicity of single WD-POM doses (1/3, 1/5, and 1/10 MTD), which are at least fifty times higher than the typically used dose (0.015 mmol W kg− 1) of tungsten-based contrast agents, was evaluated for 14 days. The results of arterial blood gas analysis, CO-oximetry status, electrolyte and lactate levels for 1/10 MTD group (80% survival rate) indicated the mixed respiratory and metabolic acidosis. The highest deposition of WD-POM (0.6 ppm tungsten) was found in the kidney, followed by liver (0.15 ppm tungsten), for which the histological analysis revealed morphological irregularities, although the renal function parameters (creatinine and BUN levels) were within the physiological range. This study is the first and important step in evaluating side effects of polyoxometalate nanoclusters, which in recent years have shown a large potential as therapeutics and contrast agents.
The Role of TLR2 in Exercise-Induced Immunomodulation in normal weight individuals
Authors: Bahman Fatemah , AlSaeed Halemah , Albeloushi Shaima , Al-Mulla Fahd , Ahmad Rasheed , Alrashed Fatema 
Published: April 2023

Abstract

BackgroundToll-like receptors (TLRs) have been targeted for therapeutic drug development for several disorders, including cardiovascular diseases, and diabetes mellitus. Daily levels physical activity (PA) has been purported to influence the systemic circulation of cytokines, affecting the overall activation of TLRs and influencing the inflammatory milieu.MethodsObjective and self-reported daily PA was tracked in 69 normal-weight adults. Freedson's cut-offs categorized daily PA intensity into the 25th lowest, medium, and top percentiles. Monocytic TLR2 expression was quantified by flow cytometry in fresh whole blood. Cross-sectional associations between flow cytometry measured TLR2+subsets and clinical biomarkers were evaluated.ResultsPA increased circulation of TLR2+monocytes. TLR2 expression was adversely corelated with reduced diastolic blood pressure (DBP), triglyceride (TG), and matrix metallopeptidase 9 (MMP9) levels. However, regression analysis indicated that only TG levels were independently linked with TLR2+subsets in circulation in active participants.ConclusionsHigher daily PA levels improve cardiovascular health by upregulating monocytic TLR2+subsets in circulation, indicating that TLR2 may modulate inflammatory cytokines under physically active lifestyles.
Investigation of Self-Compacting Concrete Behaviour Under Axial Load by Acoustic Emission Method
Authors: RESULOĞULLARI Emriye ÇINAR , DÜNDAR Behçet 
Published: April 2023

Abstract
The Acoustic Emission (AE) method is a non-destructive test method used when monitoring the damage propagation by detecting high-frequency elastic waves produced by the refraction process. Self-Compacting Concrete (SCC) is a special type of concrete that does not require vibration, has excellent fluidity, and is resistant to segregation. In this study, it is aimed to investigate the functioning of the AE technique, which is frequently used in normal concrete, in the behaviour of SCC. For this purpose, simultaneous monitoring of SCCs under uniaxial compressive load was carried out with the AE method. CEM I 42.5 R cement was used as a binder in the production of concrete, and Fly Ash (FA) and Marble Powder (MP) were used as mineral additives. In SCC mixture, stone dust was used as filler material and chemical additive Sika brand 4567 Hi-Tech was used as plasticizer. Cement dosage is 400 kg, water/powder ratio is 0.36, chemical additive ratio is 1.85%, and stone dust amount is 125 kg. The mineral additives which were used included in the mixture replaced with cement by 20%. In addition to the compressive strength of SCCs, crack analysis, AE amplitude, AE Energy, Ringing Counts and Cumulative Count results were examined as a result of AE measurements. With the AE parameters obtained as a result of the simultaneous measurement, the behaviour of SCCs under uniaxial load was successfully monitored.
Is pseudohalide CN - a real halide? An easy identification method
Authors: Qin Zhengbo 
Published: April 2023

Abstract

Recently, in the light of a great concentration devoted on pseudohalide CN− and cyano radical CN physico-chemical property studies and superhalide behavior exploration in CN− ligated metal compounds, the electronic structure nature of pseudohalide CN− has been directly demonstrated via photoelectron velocity map imaging (PE-VMI) technique as compared to that of Cl−. For the halide Cl−, photoelectrons were observed at 266 nm (4.66 eV) to peak being perpendicular to the laser polarization due to electron emission from the typically parent p orbital. For the analogous pseudohalide CN−, photoelectrons present peak along the laser polarization entirely at 266 nm. Although both of them were often regarded with the same high electron affinity and extremely strong chemical bonding capability to stabilize complexes, the photoelectron angular distributions (PADs) are quietly different, which indicates their different HOMO nature. Thus, using advanced PE-VMI technique, we demonstrate that PADs can provide detailed information about the electronic structure to distinguish electronic structures of pseudohalides and halides.
PerPsych: An iPadOS-based Open-source Neuropsychological Software for Time Perception Assessment
Authors: Gorji Arman , Jouzdani Ali Fathi 
Published: April 2023

Abstract
Background : We use neuropsychological tests to determine and monitor the impact of mental illness and brain disease on cognitive function. Assessment of time perception is a common component of neuropsychological tests. A majority of time perception studies use computer displays, although using smartphone or tablet software might offer advantages in some cases.
Result : In this study, we developed an open-source, iPadOS-based neuropsychological tool for testing time perception that makes use of the most recent hardware and software developments. We designed this software natively for iPadOS, using the low-level Metal interface to access the graphics processing unit for high-timing performance. PerPsych makes it quicker and simpler for researchers to conduct studies on time perception in individuals with cognitive impairment.
Conclusion : PerPsych is an iPadOS-based open-source neuropsychological software for time perception assessment. The information gathered using this software can be utilized in papers that attempt to monitor and diagnose neurological and psychiatric diseases.
Development of Youth Tennis Players: A Study Based on the Ranking History of Top ATP/WTA Players Worldwide, and a Comparison with Elite Chinese Players
Authors: chen hui , li caifeng , meng xianlu , chmura pawel , wei xiaobin 
Published: April 2023

Abstract
Background The top 100 ATP/WTA ranking points are a crucial indicator of entry into the high-level world of tennis players, and the number of players from a nation in this ranking reflects the overall level of their tennis. This study aims to examine the historical career ranking changes of Elite players and provide valuable insights for aspiring young players looking to achieve success in the sport.Methods In this study, data on the rankings of 202 players were analyzed. Spearman and Pearson correlations were employed to investigate the association between ranking and time-use patterns. Additionally, the variance test was utilized to compare disparities in time characteristics of the rankings, with a statistical significance level of p < 0.05.Results The study found that the majority of top tennis players are from Europe and America. There was a significant correlation between the time of entering the professional tournament ranking system and the ranking, top 100 time, top 100 age, and age of starting training. Top 50 ATP players started training, achieved their ranking, reached the top 100, and reached their top 100 age earlier than the players ranked 51–100.There was a significant difference between the age of starting training and the time to top 10 among the ATP and WTA players.Chinese female players showed no significant differences compared to their global Top 10 counterparts in terms of time-to-success characteristics, although they did take longer to move up from the 600 − 400 ranking range.Conclusions The study findings indicate that elite tennis players who achieve success typically start playing and competing in the sport at a young age, with professional competition often commencing around 18 years of age. Notably, these players frequently attain high rankings before reaching the age of 20. Furthermore, top 10 ATP male players tend to start training at an earlier age and require a shorter time to achieve a top 10 ranking compared with WTA female players. It is recommended that practitioners working with tennis players should strive to gain a deeper understanding of the factors that contribute to player success and develop more effective training programs to help players realize their full potential.
Postoperative course and indications for liver transplantation in biliary atresia: 20 years of experience in our hospital
Authors: Sumida Wataru , Shirota Chiyoe , Tainaka Takahisa , Makita Satoshi , Takimoto Aitaro , Takada Shunya , Nakagawa Yoichi , Maeda Takuya , Goda Yosuke , Yaohui Guo , Jiahui Liu , Hinoki Akinari , Uchida Hiroo , Amano Hizuru 
Published: April 2023

Abstract
Undergoing a Kasai portoenterostomy (KP) to enable the clearing of jaundice (COJ) is the only way for patients with biliary atresia (BA) to achieve native liver survival (NLS). However, COJ does not always guarantee NLS. We retrospectively reviewed the clinical course and indications for liver transplantation (LT) of BA cases in our hospital. We reviewed the clinical course of patients who underwent KP for BA at our hospital from January 2003 to June 2022 and who were followed up until December 2022. In all, we reviewed 129 cases of which 32 failed to achieve COJ, and 31 underwent LT. COJ was achieved in 97 cases. The median time to the first KP was 58 days, which was significantly earlier than the median time of 69 days of the cases who failed COJ. Of the 97 cases who achieved COJ, 25 required LT. The indications for LT included recurrent jaundice (9 cases), cholangitis (8 cases), gastrointestinal bleeding (4 cases), hepatopulmonary syndrome (3 cases), and the other (1 case). Of all cases reviewed, 55% of cases were able to live with their native liver, and 26% of cases who achieved COJ required LT.
Proposing New Potential Candidates to Inhibit EGFR via Machine Learning Algorithm
Authors: Torabi Mohammadreza , Yasami-Khiabani Setayesh , Sardari Soroush , Golkar Majid , Pérez-Sánchez Horacio , Ghasemi Fahimeh 
Published: April 2023

Abstract
One of the main issues in solid tumours is progressive mutation in epidermal growth factor receptors (EGFR) gene, which activates signalling pathways that create new blood vessels. In this study, it was attempted to find new a therapeutic candidate to inhibit EGFR. One of the cost-effective alternative methods to find new inhibitors has been the repositioning approach of existing drugs. The critical point of computational drug repositioning method is saving time and cost to remove the pre-clinical step and accelerate the drug discovery process. Hence, an ensemble computational-experimental approach, consisting of three different steps, a machine learning model, simulation of drug-target interaction and experimental characterization, was developed. The machine learning type used here was different tree classification method, which is one of the best randomize machine learning model to identify potential inhibitors from weak inhibitors. The machine learning step aimed to discover the approved drugs with the highest possible success rate in the experimental step. Finally, out of the nine chosen drugs, seven compounds had been confirmed to inhibit EGFR in the published articles since 2019. Hence, two identified compounds, in addition to gefitinib, as a positive control, and one neutral, were considered via molecular docking study. Finally, eight proposed drugs, including gefitinib, were investigated using MTT assay and In-Cell ELISA to characterise the drugs effect on A431 cell growth and EGFR-signaling. From our experiments, we could conclude that salicylic acid and piperazine could play an EGFR-inhibitor role like gefitinib.
Incidence of pathological manifestations in historic buildings: The case of the former electoral justice building, in Teixeira, Paraíba
Authors: SOUZA J. P. M. , VIEIRA V. da S. , FERREIRA L. D. F. , DAVI⁴ R. M. G. , MEDEIROS⁵ L. E. L. , LEITE⁶ M. C. A. 
Published: April 2023

Abstract

This paper presents a case study on the electoral justice building of Teixeira-PB, located in the interior of the Hinterland of Paraíba and in the immediate geographical region of Patos - PB, specifically in the municipality Teixeira. This is an exploratory and explanatory research, with a quali-quantitative approach. The methodology of the project included a bibliographic study, for possible analyses between studies already done on facades of historical buildings and the object of study of this research: the old Electoral Justice building in Teixeira - PB. Through the analysis of photographic records, damage identification forms (FID) and a damage map that contemplates all the facades of the building were prepared. Finally, the GUT methodology was applied to categorize the most aggravating pathological manifestations of the building, aiming to contribute to the understanding of the building's situation. In view of the analysis, it was noticed the high rate of anthropic mechanisms, i.e., the damage found could be solved or prevented, by performing preventive or corrective maintenance, planned and executed by a technical staff specialized in restoration of historic buildings. Therefore, this research starts from the necessity and importance of the conservation of the historical goods of an urban reality as a way to preserve and value the memory of the people and proposes to investigate and to document the result of the interventions carried out in the building, its constructive system, the damages found in the facades and the situation in relation to the degradation of the building.
Tumor necrosis factor-alpha mediates the association between telomere length and kidney dysfunction in patients with hypertension
Authors: Qi Mengya , Yu Jie , Ping Fan , Xu Lingling , Li Wei , Zhang Huabing , Li Yuxiu 
Published: April 2023

Abstract
Aim/hypothesis: The relationship between peripheral blood leukocyte telomere length (LTL) and kidney dysfunction, especially in people with hypertension, remains unclear. No clinical study has explored the role of oxidative stress and inflammatory markers in the relationship between LTL and kidney dysfunction. Therefore, we examined the relationship between baseline LTL and albuminuria progression and/or rapid renal function decline in Chinese patients with or without hypertension, and investigated whether oxidative stress and inflammation play a mediating role in this relationship.
Methods: We conducted a prospective study including 262 patients in a 7-year follow-up period from 2014 to 2021. Data on LTL, inflammation, oxidative markers, renal function, and urine protein levels were assessed. Kidney dysfunction was defined as either albuminuria progression, rapid decline in renal function, or the composite endpoint (albuminuria progression and rapid decline in renal function). Logistic regression and simple mediation models were used for the analysis.
Results: In this cohort (mean age, 53.18±11.32 years; follow-up period, 5.97±1.16 years), 43, 22, and 59 patients developed albuminuria progression, rapid renal decline, and the composite endpoint of kidney dysfunction, respectively. Logistic regression analysis showed that each standard deviation decrease in the lower quartile (Q) of baseline LTL was correlated with an increased risk of albuminuria progression (odds ratio [OR]=1.493 [95% confidence interval (CI) 0.985, 2.263], P=0.059; OR=3.307 [95% CI 1.033, 10.586], P=0.044; Q2 vs. Q4); rapid renal function decline (OR=2.402 [95% CI 1.361, 4.239], P=0.002; OR=13.457 [95% CI 1.610, 112.472], P=0.016; Q1 vs. Q4); and the composite endpoint of kidney dysfunction (OR=1.797 [95% CI 1.244, 2.594], P=0.002; OR=4.062 [95% CI 1.426, 11.568], P=0.009; Q1 vs. Q4). Subgroup analyses showed that LTL was inversely associated with albuminuria progression and the composite endpoint of kidney dysfunction in patients with hypertension (OR=5.671 [95% CI 1.203, 26.726], P=0.028; OR=4.223 [95% CI 1.297, 13.753], P=0.017), but not in those without hypertension. The mediating analysis showed that tumor necrosis factor (TNF)-α partly mediated the relationship between LTL and rapid decline in renal function (direct effect: β= –0.6791 [–1.2145, –0.1438]; indirect effect: β= –0.2919 [–0.5190, –0.1177]).
Conclusion: Baseline LTL could independently predict kidney dysfunction at follow-up, especially in participants with hypertension. TNF-α partially mediated the negative association between LTL and kidney dysfunction.