bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consistent neutralization of circulating omicron sub‐variants by hybrid immunity up to 6 months after booster vaccination
Authors: Cheung Allen K. L. , Lu Yingying , Zhu Yufang , Fung Tsz Yan , Zheng Yulan , Zheng Zhihua , Hong Peng 
Published: March 2023

AbstractThe current COVID‐19 vaccination program requires frequent booster vaccination to maintain sufficient neutralization levels against immune evasive SARS‐CoV‐2 variants. However, prior studies found more potent and durable immune response in convalescing individuals, raising the possibility of less frequent booster vaccination for them. Here, we conducted a longitudinal immunological study based on two prospective cohorts of booster vaccinated convalescing COVID‐19 patients or healthcare workers (HCW) without COVID‐19 history in Xiangyang, China. Comparing to 1‐month post‐boosting, pseudovirus neutralization titers (pVNT50) of ancestral Wuhan‐Hu‐1 and circulating omicron sub‐variants BA.5, BF.7, BA.4.6, BA.2.75, and BA.2.75.2 spikes were stable or even increased in convalescing samples at 6‐month post‐boosting, when HCW samples showed substantial drop of neutralization titers across the spectrum. Variant‐to‐Wuhan‐Hu‐1 pVNT50 ratios showed no significant variation during the 17 months from pre‐vaccination to 6‐month post‐boosting in convalescing individuals, indicating that the high durability of hybrid immunity was likely sustained by continuously improving neutralization potency that compensated immune decay. Our data provide mechanistic insight into prior epidemiological findings that vaccine‐elicited humoral immune response was more durable in convalescing individuals than those without SARS‐CoV‐2 infection, and suggest further research into potential extension of boosting intervals for convalescing individuals.
Cardiac arrhythmia detection using cross‐sample entropy measure based on short and long RR interval series
Authors: Sharma Kanchan , Sunkaria Ramesh Kumar 
Published: March 2023

AbstractBackgroundAccurate arrhythmia (atrial fibrillation (AF) and congestive heart failure (CHF)) detection is still a challenge in the biomedical signal‐processing field. Different linear and nonlinear measures of the electrocardiogram (ECG) signal analysis are used to fix this problem.MethodsSample entropy (SampEn) is used as a nonlinear measure based on single series to detect healthy and arrhythmia subjects. To follow this measure, the proposed work presents a nonlinear technique, namely, the cross‐sample entropy (CrossSampEn) based on two series to quantify healthy and arrhythmia subjects.ResultsThe research work consists of 10 records of normal sinus rhythm, 20 records of Fantasia (old group), 10 records of AF, and 10 records of CHF. The method of CrossSampEn has been proposed to obtain the irregularity between two same and different R–R (R peak to peak) interval series of different data lengths. Unlike the SampEn technique, the CrossSampEn technique never awards a ‘not defined’ value for very short data lengths and was found to be more consistent than SampEn. One‐way ANOVA test has validated the proposed algorithm by providing a large F value and p < .0001. The proposed algorithm is also verified by simulated data.ConclusionsIt is concluded that different RR interval series of approximate 1500 data points and same RR interval series of approximate 1000 data points are required for health‐status detection with embedded dimensions, M = 2 and threshold, r = .2. Also, CrossSampEn has been found more consistent than Sample entropy algorithm.
Fragranced consumer products: Formulation practices, related models, and recommendations to enable wider hydrophilic–lipophilic difference (HLD) application
Authors: Falk Nancy 
Published: March 2023

AbstractFragrances in consumer products are essential for appeal and market success. However, creating optimal stable formulas are especially challenging due to the polar nature of many fragrance ingredients. This perspective discusses how fragrances are currently dealt with within the industry, current surfactant and solvent models, and the barriers that today's industrial practice that prevent advancement to modeling and simulation. Recommendations for chemical suppliers, fragrance houses, and formulators are made regarding the implementation of the Hydrophilic‐Lipophilic Difference with Net Average Curvature (HLD‐NAC) model, which is the most comprehensive model for fragranced aqueous consumer products.
A Magnetic Bio‐Inspired Soft Carrier as a Temperature‐Controlled Gastrointestinal Drug Delivery System
Authors: Heunis Christoff M. , Wang Zhuoyue , de Vente Gerko , Misra Sarthak , Venkiteswaran Venkatasubramanian Kalpathy 
Published: March 2023

AbstractCurrently, gastrointestinal bleeding in the colon wall and the small bowel is diagnosed and treated with endoscopes. However, the locations of this condition are often problematic to treat using traditional flexible and tethered tools. New studies commonly consider untethered devices for solving this problem. However, there still exists a gap in the extant literature, and more research is needed to diagnose and deliver drugs in the lower gastrointestinal tract using soft robotic carriers. This paper discusses the development of an untethered, magnetically‐responsive bio‐inspired soft carrier. A molding process is utilized to produce prototypes from Diisopropylidene‐1,6‐diphenyl‐1,6‐hexanediol‐based Polymer with Ethylene Glycol Dimethacrylate (DiAPLEX) MP‐3510 ‐ a shape memory polymer with a low transition temperature to enable the fabrication of these carriers. The soft carrier design is validated through simulation results of deformation caused by magnetic elements embedded in the carrier in response to an external field. The thermal responsiveness of the fabricated prototype carriers is assessed ex vivo and in a phantom. The results indicate a feasible design capable of administering drugs to a target inside a phantom of a large intestine. The soft carrier introduces a method for the controlled release of drugs by utilizing the rubbery modulus of the polymer and increasing the recovery force through magnetic actuation.
Clinical characteristics of anti‐AChR‐MuSK‐LRP4 antibody‐negative myasthenia gravis in China
Authors: Li Wenbo , Liu Peipei , Cui Weike , Wang Shumin , Ji Ying , Zhang Linyuan , He Xiaoxiao , Zhou Shuxian , Shen Tong , Zhao Xue , Lv Jie , Zhang Yingna , Zhang Jing , Fang Hua , Yang Junhong , Zhang Yunke , Cui Xinzheng , Zhang Qingyong , Gao Feng 
Published: March 2023

AbstractIntroduction/AimsDescriptions of the clinical characteristics of anti‐AChR‐MuSK‐LRP4 antibody‐negative myasthenia gravis (triple‐negative myasthenia gravis, TNMG) are lacking in the current literature. Therefore, we investigated the clinical characteristics of TNMG in Chinese patients.MethodsWe retrospectively analyzed 925 patients with MG registered in the Department of Neuroimmunology, Henan Institute of Medical and Pharmaceutical Sciences from January 2015 to March 2021.ResultsOne hundred six patients diagnosed with TNMG were included in the study. The average age of onset was 32.4 y, with a male‐to‐female ratio of 1:1. The age of onset showed a bimodal distribution: 0–9 y and 40–49 y. Adult patients were more likely to have weakness of limb and bulbar muscles (p < .05). Thymic hyperplasia was found in 20.2% of the patients. Younger patients were more likely to relapse. The rate of adult early‐onset myasthenia gravis reaching complete stable remission and pharmacological remission was 47.6%, and the prognosis was better than that in juvenile‐onset myasthenia gravis (p = .019). Older age of onset was the only risk factor for the development of generalized TNMG from ocular TNMG (R = 1.046, p = .002, 95% confidence interval 1.017–1.077).DiscussionThis study showed that the clinical characteristics of patients with TNMG varied among the different age groups. Significant findings included a bimodal distribution of onset age, coexisting thymic hyperplasia, and a generally favorable prognosis.
Experimental and modelling investigation of vibration‐induced fluidization in sheared granular soils
Authors: Xie Tao , Guo Peijun , Stolle Dieter 
Published: March 2023

AbstractVibration‐induced fluidization (ViF) is a phenomenon where a granular medium completely loses shear resistance or flows continuously under vibration and thus behaves like a fluid without invoking remarkable excess pore pressure. This paper attempts to investigate ViF through a series of modified triaxial tests and using an extended shear‐transformation‐zone (STZ) model that correlates macroscopic plastic deformation to the motion of internal mesoscopic weak spots (i.e., STZs) within granular materials. The test results revealed that the ViF may take place when the vibration is applied at either critical or non‐critical states. Theoretical analyses using the extended STZ model show that the vibration intensity required to cause fluidization increases linearly with the initial quasi‐static shear stress level at which vibration is imposed. The model results are generally consistent with experimental data, indicating that the extended STZ model has a desirable performance in simulating the fluidization of granular soil subjected to quasi‐static shearing and vibration simultaneously.
Children's Oncology Group KidsCare smartphone application for parents of children with cancer
Authors: Landier Wendy , Campos Gonzalez Paula D. , Henneberg Harrison , York Jocelyn M. , Wadhwa Aman , Adams Kandice , Madan‐Swain Avi , Wolfson Julie Anna , Benton Beth , Seidel Cindi , Slater Valencia , Snuggs Kim , Folsom Amy , Miller Jeneane , Tomlinson Kathryn , Zupanec Susan , Bhatia Smita 
Published: March 2023

AbstractBackgroundParents of children with cancer must learn and retain crucial information necessary to provide safe care for their child. Smartphone applications (apps) provide a significant opportunity to meet the informational needs of these parents. We aimed to develop, refine, and evaluate a smartphone app, informed by the Children's Oncology Group (COG) expert consensus recommendations, to support the informational needs of parents of children with cancer.ProcedureWe employed a user‐centered iterative mixed‐methods approach in two phases (prototype development/refinement and pilot testing). We engaged parents and clinicians in evaluating the app via qualitative interviews and standardized tools that measured app quality (Mobile Application Rating Scale [MARS]), usability (System Usability Scale [SUS]), and acceptability (System Acceptability Scale [SAS]). We evaluated early usage patterns after public release.ResultsThirty‐two parents and 17 clinicians participated. Mean (± standard deviation [SD]) scores for app quality, usability, and acceptability were: MARS: 4.5 ± 0.7 on a 5‐point scale; SUS: 86.7 ± 23.8 on a 100‐point scale; and SAS: superior (61%); similar (28%); inferior (11%) to written materials. Qualitative findings largely confirmed the quantitative data. Downloads of the app during the first year following public release have exceeded 5000.ConclusionsThe COG KidsCare app prototype was found to be of high quality and received high usability and acceptability ratings. Further testing is needed to determine app effectiveness in improving parental knowledge regarding care of children with cancer.
Thermal and dielectric multiple percolation in α‐Si3N4 whiskers/silicone rubber
Authors: Zhang Dian , Liu Jiawen , Yang Xiaofeng , Liu Xuan , Liang Qingquan , Liu Yijun 
Published: March 2023

AbstractCurrently, thermal interfacial materials (TIMs) play a great role to electronic and semiconductor devices working at high voltage, power and frequency. The urgent need for electrical insulating TIMs and relevant theory are not addressed yet. This study adopted an electrical insulating α‐Si3N4 whisker as a filler to prepare Si3N4w/silicone rubber. The results show that the elongation at break and thermal conductivity of silicone rubber are promoted from 91.6% and 0.343 to 402.9% and 1.011 W m−1 K−1, respectively, at a filler fraction of 8.0 vol%. It reveals a multiple percolation phenomenon which has not been previously observed in an electrical insulating TIMs. The thermal percolation threshold is decreased to 4.0 vol% with increasing aspect ratio of the whisker. The behavior of the dielectric strength is explained by a double percolation model. A phonon quasi‐ballistic transportation mechanism based on Coulomb interactions is proposed for the TIMs.
High glass transition temperature and ultra‐low thermal expansion coefficient polyimide films containing rigid pyridine and bisbenzoxazole units
Authors: Luo Feng , Lin Chengjiang , Jiao Long , Du Zhijun , Dong Zhixin , Dai Xuemin , Duan Xiaozheng , Qiu Xuepeng 
Published: March 2023

AbstractPolyimide (PI) films with extremely high heat‐resisting and dimensional stability are ideal substrate materials for flexible organic light‐emitting diodes. In this study, three diamines containing rigid bisbenzoxazole structures, 2,2′‐p‐phenylenebis(5‐aminobenzoxazole) (phDBOA), 2,2′‐m‐pyridylenebis(5‐aminobenzoxazole), and 2,2′‐p‐pyridylenebis(5‐aminobenzoxazole) (p‐PDBOA), were polymerized with 3,3′,4,4′‐biphenyl tetracarboxylic dianhydride and pyromellitic dianhydride (PMDA) separately with traditional two‐step approach to prepare a set of PI films. Introduction of bisbenzoxazole improves stiffness of molecular chain, whereas that of pyridine increases in‐plane orientation and molecular chain tend to be densely stacked. Among prepared films, PI‐6 (PMDA/p‐PDBOA) shows the most excellent mechanical properties, with an ultra‐high glass transition temperature of >450°C, an ultra‐low thermal expansion coefficient of <5 ppm K−1 (50–450°C), a tensile strength of 259 MPa, and a modulus of 8.3 GPa. Given these excellent properties, PI‐6 could be applied in flexible display.
A colour indicator film based on bromothymol blue/poly‐L‐lactic acid/polyvinylpyrrolidone for detecting bacteria
Authors: Jia Lu , Sun Wuliang , Li Wenbo , Dong Yue , Wu Lingling , Saldaña Marleny D. A. , Gao Yang , Jin Ye , Sun Wenxiu 
Published: March 2023

AbstractThe unintentional bacterial contamination in food seriously harms food quality and human health, so it is necessary to establish a real‐time bacterial detection method. Here, a colour indicator film was designed to detect bacterial by incorporating bromothymol blue (BTB) into degradable poly‐L‐lactic acid (PLLA) and polyvinylpyrrolidone (PVP). The colour indicator film was prepared into fibres by electrospinning technology. The colour indicator film showed colour responsiveness from yellow to green at different pH. The colour indicator film showed good colour stability at different temperature and humidity conditions. The colour indicator film was used for the detection of bacteria, and it was found that the colour indicator film could make a colour response visible to the naked eye according to different concentrations of bacteria, which showed the great potential of the colour indicator film in detecting bacteria.
Video‐assisted surgical diagnosis and pleural adhesion management in catamenial pneumothorax: A case and literature review
Authors: Pratomo Irandi Putra , Putra Muhammad Arza , Bangun Lidia Giritri , Soetartio Isti Mardiana , Maharani Maria Angela Putri , Febriana Irene Sinta , Soehardiman Dicky , Prasenohadi Prasenohadi , Kinasih Tutug 
Published: March 2023

AbstractCatamenial pneumothorax is a rare primary spontaneous pneumothorax associated with the menstrual phase and is the most common manifestation of thoracic endometriosis syndrome. We report a case of a 32‐year‐old woman with a history of endometriosis who presented to the emergency ward with a chief complaint of dyspnea and right‐sided chest pain, and a chest X‐ray showed a right pneumothorax. Initial management was by placing a chest tube to expand the right lung. The patient underwent a video‐assisted thoracoscopy and talc pleurodesis, during which we found multiple perforations in the tendinous part of the diaphragm. A partial resection of the tendinous part of the diaphragm was done. Our review indicated that primary spontaneous pneumothorax in women should be suspected as catamenial pneumothorax due to thoracic endometriosis. The gold standard procedure for diagnosis and treatment is surgery. Hormonal therapy is an effective choice to prevent and reduce post‐operative recurrence.
Carvacrol protects against λ‐Cyhalothrin‐induced hepatotoxicity and nephrotoxicity by modulating oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy
Authors: Ileriturk Mustafa , Kandemir Fatih Mehmet 
Published: March 2023

Abstractλ‐Cyhalothrin, a type II synthetic pyrethroid, has been widely used in households, agriculture, public health, and gardening to control insect pests. Despite its widespread usage, it is known to induce a variety of adverse effects, including hepatotoxicity and nephrotoxicity. The goal of this study was to investigate the protective effect of carvacrol, which has antioxidant, anti‐inflammatory, anti‐apoptotic, and some other properties, on λ‐Cyhalothrin‐induced hepatotoxicity and nephrotoxicity 35 male Sprague–Dawley rats were randomly divided into five groups for this purpose: I‐Control group: II‐CRV group (50 mg/kg carvacrol), III‐LCT group (6.23 mg/kg LCT), IV‐LCT + CRV 25 group (6.23 mg/kg LCT + 25 mg/kg carvacrol), and V‐LCT + CRV 50 group (6.23 mg/kg LCT + 50 mg/kg carvacrol). Using biochemical, real‐time PCR, and western blotting methods, the collected tissues were analyzed. While λ‐Cyhalothrin treatment increased MDA levels, which are indicated of lipid peroxidation, but reduced SOD, CAT, GPx activities, and GSH levels. After receiving carvacrol therapy, the degree of oxidative stress reduced as the values of these parameters approached those of the control group. Increased inflammation, apoptosis, endoplasmic reticulum stress, and autophagy with λ‐Cyhalothrin administration reduced with carvacrol co‐administration, and liver and kidney tissues were protected from damage, depending on the degree of oxidative stress. After considering all of these data, it was discovered that λ‐Cyhalothrin‐induced oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy in the liver and kidneys; however, carvacrol protected the tissues from damage. Our findings indicate that carvacrol may be a promising protective agent in λ‐Cyhalothrin‐induced hepatotoxicity and nephrotoxicity.
Antrodia camphorata and coenzyme Q0, a novel quinone derivative of Antrodia camphorata, impede HIF‐1α and epithelial‐mesenchymal transition/metastasis in human glioblastoma cells
Authors: Yang Hsin‐Ling , Chang Yao‐Hsien , Pandey Sudhir , Bhat Asif Ali , Vadivalagan Chithravel , Lin Kai‐Yuan , Hseu You‐Cheng 
Published: March 2023

AbstractAntrodia camphorata (AC) and Coenzyme Q0 (CoQ0), a novel quinone derivative of AC, exhibits antitumor activities. The present study evaluated EMT/metastasis inhibition and autophagy induction aspects of AC and CoQ0 in human glioblastoma (GBM8401) cells. Our findings revealed that AC treatment (0–150 μg/mL) hindered tumor cell proliferation and migration/invasion in GBM8401 cells. Notably, AC treatment inhibited HIF‐1α and EMT by upregulating epithelial marker protein E‐cadherin while downregulating mesenchymal proteins Twist, Slug, Snail, and β‐catenin. There was an appearance of the autophagy markers LC3‐II and p62/SQSTM1, while ATG4B was downregulated by AC treatment. We also found that CoQ0 (0–10 μM) could inhibit migration and invasion in GBM8401 cells. In particular, E‐cadherin was elevated and N‐cadherin, Vimentin, Twist, Slug, and Snail, were reduced upon CoQ0 treatment. In addition, MMP‐2/‐9 expression and Wnt/β‐catenin pathways were downregulated. Furthermore, autophagy inhibitors 3‐MA or CQ reversed the CoQ0‐elicited suppression of migration/invasion and metastasis‐related proteins (Vimentin, Snail, and β‐catenin). Results suggested autophagy‐mediated antiEMT and antimetastasis upon CoQ0 treatment. CoQ0 inhibited HIF‐1α and metastasis in GBM8401 cells under normoxia and hypoxia. HIF‐1α knockdown using siRNA accelerated CoQ0‐inhibited migration. Finally, CoQ0 exhibited a prolonged survival rate in GBM8401‐xenografted mice. Treatment with Antrodia camphorata/CoQ0 inhibited HIF‐1α and EMT/metastasis in glioblastoma.
Genomic‐assisted breeding for climate‐smart coffee
Authors: Ferrão Maria Amélia G. , da Fonseca Aymbire F. A. , Volpi Paulo S. , de Souza Lucimara C. , Comério Marcone , Filho Abraão C. Verdin , Riva‐Souza Elaine M. , Munoz Patricio R. , Ferrão Romário G. , Ferrão Luís Felipe V. 
Published: March 2023

AbstractCoffee is a universal beverage that drives a multi‐industry market on a global basis. Today, the sustainability of coffee production is threatened by accelerated climate changes. In this work, we propose the implementation of genomic‐assisted breeding for climate‐smart coffee in Coffea canephora. This species is adapted to higher temperatures and is more resilient to biotic and abiotic stresses. After evaluating two populations, over multiple harvests, and under severe drought weather condition, we dissected the genetic architecture of yield, disease resistance, and quality‐related traits. By integrating genome‐wide association studies and diallel analyses, our contribution is four‐fold: (i) we identified a set of molecular markers with major effects associated with disease resistance and post‐harvest traits, while yield and plant architecture presented a polygenic background; (ii) we demonstrated the relevance of nonadditive gene actions and projected hybrid vigor when genotypes from different geographically botanical groups are crossed; (iii) we computed medium‐to‐large heritability values for most of the traits, representing potential for fast genetic progress; and (iv) we provided a first step toward implementing molecular breeding to accelerate improvements in C. canephora. Altogether, this work is a blueprint for how quantitative genetics and genomics can assist coffee breeding and support the supply chain in the face of the current global changes.
Anaerobic digestion of agro‐industrial waste enriched with bovine bone meal for improved biogas production and biofertilization
Authors: Hadidi Meryem , Bahlaouan Bouchaib , Boutaleb Fatimazahra , Benjelloun Ghita Radi , Silkina Alla , Antri Said El , Boutaleb Nadia 
Published: March 2023

AbstractThe increase in animal and agro‐industrial production must be accompanied by the development of appropriate waste and by‐product management strategies. Anaerobic digestion is a promising approach to recycle these wastes and reintegrate them into the economic production cycle of biogas and biofertilizer. In order to improve the performance of the anaerobic mesophilic digestion of abundant agro‐industrial wastes constituted by potato peel (PP), and poultry waste (PW) and study the contribution of bovine bone meal (BB) as additive rich in phosphorus, which can help to neutralize the acidity of the substrate. The 10‐point simplex‐centroid design and the isoresponse surfaces strategy were used. This study demonstrated that in mesophilic bio‐digestion, the using bovine bones in admixture with agroindustrial residue provided for the proper balance of chemical components required for proliferation of microbiological agent of bioconversion, which also resulted in an increase in biogas production capacity. The best formula was so composed by 66.67% bovine bone, 16.67% potatoes peel, and 16.67% poultry waste. The stability was achieved here after only 12 days. The digestate generated from it was fulfilled with the microbiological and chemical requirements for safety defined by the NF U44‐551 standard. Germination test revealed that this optimal produced digestate, did not hinder growth, in fact, almost 85% of seed was germinated. Finally, fertilization experiments prove that this digestate can boost the growth of bell pepper (Capsicum annuum).