bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Nocturnal Blood Pressure Matter in Retinal Small Vessels? A Systematic Review and Meta-Analysis of the Literature
Authors: Antza Christina , Palaska Smaro , Anyfanti Panagiota , Triantis Dimitris , Fyntrilakis Stavros , ZiyaSener Yusuf , Kotsis Vasilios 
Published: January 2025

Abstract

Purpose of the review
Τhe association between nocturnal blood pressure (BP) and alterations in the retinal microvasculature remains understudied, with few available studies to provide conflicting results. Therefore, we conducted a systematic review and meta-analysis to determine whether an association exists between retinal microvascular alterations and nocturnal BP patterns, determined by 24h ambulatory BP measurement.

Recent findings
Our search concluded to 1002 patients (6 studies). A total of 3 studies (411 patients) were enrolled in the meta-analysis. Central retinal arteriolar equivalent found to be not different between patients with and without dipping status (mean differences [MD]: -0.01; 95% CI: -0.23 to 0.20; I²=0%; P < 0.610). Regarding central retinal venular equivalent, dippers showed significantly lower values compared to non-dippers (MD: -0.25; 95% CI: -0.47 to -0.03; I²=0%; P < 0.024). For the comparison between nighttime and daytime BP regarding the damage in small retinal vessels, we identified only 5 studies. Due to different evaluated outcomes as well as due to the heterogeneity of outcomes and different grouping of patients based on different BP cut-off values, these results couldn’t be analyzed quantitatively.

Summary
In summary, this is the first effort to summarize evidence on the effects of day-to-night variation of BP on the retinal small vessels. According to the findings of the present systematic review and meta-analysis, non-dipping status may be associated with retinal venular dilatation, and elevated nighttime BP with retinal arteriolar narrowing. Further studies are warranted to elucidate the impact of nocturnal BP patterns in the retinal microvasculature.
Impact of Voriconazole Therapeutic Drug Monitoring on Adverse Effects and Clinical Outcomes: A Literature Review
Authors: Clary Ryan T. , Deja Erin , Rittmann Barry , Bearman Gonzalo 
Published: January 2025

Abstract

Purpose of Review
Voriconazole is a broad-spectrum antifungal agent commonly used to treat severe fungal infections. Significant interindividual variability in drug metabolism can lead to subtherapeutic or toxic serum levels impacting clinical outcomes and risk for adverse effects. This review aims to summarize and evaluate evidence that assesses the impact of voriconazole therapeutic drug monitoring (TDM) on clinical outcomes and adverse effects.

Recent Findings
Many factors contribute to variability in serum voriconazole levels, such as CYP2C19 polymorphism, hepatic function, etc. TDM can aid in the management of narrow therapeutic index medications like voriconazole to optimize clinical outcomes. Current literature indicates that TDM improves clinical outcomes and reduces adverse effects by helping achieve therapeutic serum concentrations.

Summary
Voriconazole TDM is a valuable tool in optimizing treatment outcomes and minimizing adverse effects. Individualized dosing guided by TDM, helps achieve therapeutic serum levels, particularly in patients with variable metabolism enhancing the efficacy of treatment for invasive fungal infections.
Shear wave elastography for thyroid nodule evaluation in patients with chronic autoimmune thyroiditis
Authors: Latia Monica , Bena Andreea , Moisa-Luca Luciana , Bunceanu Ștefania , Stoian Dana 
Published: January 2025

Abstract

Purpose
Shear wave elastography (SWE) is a valuable tool in discerning the malignancy risk of thyroid nodules. This study investigates whether 2D-SWE can reliably differentiate malignant thyroid nodules in patients with chronic autoimmune thyroiditis (CAT), despite the challenges posed by fibrosis, which can increase tissue stiffness and complicate diagnosis.

Methods
This retrospective observational study evaluated 130 thyroid nodules (91 benign, 39 malignant) in patients with underlying CAT using conventional ultrasound (B-mode) and 2D-SWE with SuperSonic Mach30 equipment (Supersonic Imagine, Aix-en-Provence, France). Pathology reports served as the reference standard.

Results
Out of the 130 nodules, 30% were malignant, and 70% were benign. 2D-SWE proved to be an excellent distinguisher between benign and malignant nodules. Malignant nodules had significantly higher elasticity indices compared to benign nodules (mean elasticity index: 47.2 kPa vs. 18.1 kPa, p < 0.0001; maximum elasticity index: 75 kPa vs. 26.2 kPa, p < 0.0001). The mean elasticity index was the most reliable elastographic parameter (AUC 0.907, sensitivity 87.2% [95% CI: 77.3–94.0%], specificity 84.6% [95% CI: 75.4–91.5%], and NPV 93.9% for a cut-off value of 30.5 kPa).

Conclusion
Our results confirm that 2D-SWE can accurately diagnose malignant thyroid nodules in cases with CAT (p < 0.0001), supporting its use as a complementary tool to conventional ultrasound.
The effects of mindfulness-based intervention on social anxiety, mindfulness, intolerance of uncertainty and emotion dysregulation——a serial multiple mediating structural equation model
Authors: Jiang Xiaochun , Zhang Anbang , Zhang Qian 
Published: January 2025

Abstract
To investigate the potentially unique effects of mindfulness practice on social anxiety in college-bound high school seniors and explore the psychological mechanisms by which it works, this study compared the mindfulness-based intervention (MBI) group with the wait-list control (WLC) group. A total of 66 students who had just graduated from high school and were about to enter college were randomly assigned to the MBI group (n = 33) or WLC group (n = 33) and conducted self-reported mindfulness, intolerance of uncertainty, emotion dysregulation, and social anxiety at baseline and post-intervention. Repeated measurement analysis of variance demonstrated that variables varied significantly over group (MBI group and WLC group) × time (pre-test and post-test). Based on structural equation models (SEM), it has been demonstrated the change in the degrees of mindfulness, intolerance of uncertainty, and emotion dysregulation plays a partial mediating role in the process of alleviating the level of social anxiety with mindfulness intervention. MBI can not only directly affect social anxiety, but also indirectly affect the level of social anxiety through three paths. In conclusion, MBI can effectively help high school leavers improve their level of mindfulness, reduce unbearable uncertainty and emotion dysregulation. Moreover, MBI can alleviate social anxiety in high school graduates preparing for university by improving their level of mindfulness and reducing intolerance of uncertainty and emotion dysregulation.
Oxidative Depolymerization of Lignosulfonates for Muconic Acid Production Using Recombinant Pseudomonas putida CJ475
Authors: Bekirovska Selda , Lund Fredrik , Ajakaiye Jensen Lucy I. , Hulteberg Christian P. , Gorwa-Grauslund Marie F. , Abdelaziz Omar Y. 
Published: January 2025

Abstract
Lignosulfonate, a macromolecular byproduct derived from the paper and pulp industry, is a promising feedstock for bioconversion processes due to its rich carbon content and widespread availability. We here present an approach for the production of muconic acid through the optimization of the oxidative depolymerization of lignosulfonate and its further conversion using a recombinant Pseudomonas putida strain. This process yielded a stream containing a diverse mixture of low-molecular-weight aromatic compounds, the highest yield being that of vanillin, of 5.77 wt%. When bioconversion was performed with the P. putida strain CJ475, previously engineered for the conversion of vanillin to muconic acid, no conversion was initially observed due to the inhibitory effect of the depolymerized lignosulfonate fraction on bacterial growth. However, a simple additional extraction step with ethyl acetate led to the successful conversion of the substrate with a yield of 1.3 ± 0.06 mol muconic acid/mol vanillin in the stream. This study demonstrates the feasibility of utilizing oxidatively depolymerized lignosulfonates as a sustainable carbon source for biobased muconic acid production. It also marks a significant step forward in the utilization of lignocellulosic biomass for sustainable high-value biochemical production, as well as providing valuable insights into the development of bioprocesses utilizing complex, lignin-rich feedstocks.

Graphical Abstract
Reducing Healing Period with DDM/rhBMP-2 Grafting for Early Loading in Dental Implant Surgery
Authors: Ku Jeong-Kui , Lim Jung-Hoon , Lim Jung-Ah , Um In-Woong , Kim Yu-Mi , Yun Pil-Young 
Published: January 2025

Abstract

Background:
Traditionally, dental implants require a healing period of 4 to 9 months for osseointegration, with longer recovery times considered when bone grafting is needed. This retrospective study evaluates the clinical efficacy of demineralized dentin matrix (DDM) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) during dental implant placement to expedite the osseointegration period for early loading.

Methods:
Thirty patients (17 male, 13 female; mean age 55.0 ± 8.8 years) requiring bone grafts due to implant fixture exposure (more than four threads; ≥ 3.2 mm) were included, with a total of 96 implants placed. Implants were inserted using a two-stage protocol with DDM/rhBMP-2 grafts. Early loading was initiated at two months postoperatively in the mandible and three months in the maxilla. Clinical outcomes evaluated included primary and secondary stability (implant stability quotient values), healing period, bone width, and marginal bone level assessed via cone-beam computed tomography.

Results:
All implants successfully supported final prosthetics with a torque of 50Ncm, without any osseointegration failures. The average healing period was 69.6 days in the mandible and 90.5 days in the maxilla, with significantly higher secondary stability in the mandible (80.7 ± 6.7) compared to the maxilla (73.0 ± 9.2, p < 0.001). Histological analysis confirmed new bone formation and vascularization.

Conclusion:
DDM/rhBMP-2 grafting appears to significantly reduce the healing period, enabling early loading with stable and favorable clinical outcomes.
∆9-Tetrahydrocannabinol Increases Growth Factor Release by Cultured Adipose Stem Cells and Adipose Tissue in vivo
Authors: Ruhl Tim , Benic Sofija , Plum Melissa , Kim Bong-Sung , Beier Justus P. , Schaefer Benedikt 
Published: January 2025

Abstract

BACKGROUND:

Because of its biocompatibility and its soft and dynamic nature, the grafting of adipose tissue is regarded an ideal technique for soft-tissue repair. The adipose stem cells (ASCs) contribute significantly to the regenerative potential of adipose tissue, because they can differentiate into adipocytes and release growth factors for tissue repair and neovascularization to facilitate tissue survival. The present study tested the effect of administering a chronic low dose of ∆9-tetrahydrocannabinol (THC) on these regenerative properties, in vitro and in vivo.

METHODS:

Human ASCs were exposed to increasing concentrations of THC. Resazurin conversion was applied to investigate the effect on metabolic activity, cell number was assessed by crystal violet staining, tri-linear differentiation was evaluated by specific colorimetric approaches, and the release of growth factors was analyzed by ELISA. Two groups of mice were treated daily either with a low dose of THC (3 mg/kg) or a vehicle solution. After 3 weeks, adipose tissue was obtained from excised fat deposits, homogenized and tested for growth factor contents.

RESULTS:

THC decreased ASC proliferation but increased metabolic activity as well as adipogenic and chondrogenic differentiation. A low concentration of THC (1 µM) enhanced the growth factor release by ASCs. The concentration of these cytokines was also increased in adipose tissue of mice treated with THC.

CONLUSION:

Our results indicate that chronic activation of the endocannabinoid system promoted differentiation and growth factor release of ASCs, which could be of specific value for enhancing the regenerative potential of adipose tissue.
Reframing exploitation: Assessing the utility of the seafood slavery trope
Authors: Ford Michele , Palmer Wayne 
Published: January 2025

Abstract
Seafood slavery refers to various forms of forced labour, human trafficking, debt bondage, and other abusive practices experienced by workers in the commercial fishing sector. It is a powerful trope in international campaigns highlighting the different forms of exploitation experienced by migrant fishers in global seafood supply chains. These campaigns are, however, largely silent about the experiences of domestic fishers employed by domestic fleets in domestic waters. This study shows that these domestic fishers may be subjected to equally bad – if not worse – conditions than migrant fishers employed on foreign fleets. Drawing on observational data and a total of 307 interviews, we demonstrate that Indonesia’s domestic fishers in fact meet all criteria identified in the literature on seafood slavery. We then assess the implications, both positive and negative, of using the seafood slavery trope to describe the exploitation they experience. Based on this assessment, we argue that – while the seafood slavery trope potentially offers some of the same benefits in terms of attracting public attention – its focus on extreme forms of exploitation, and emphasis on the criminal rather than then the industrial mean that it is ultimately poorly suited for either cohort. The concept of labour justice, we conclude, offers a better way to identify concrete steps that can be taken to begin to address the system.
Fatigue assessment of welded pure copper hairpins using notch stress concept
Authors: Ceruso Jesse , Mannsperger Max , Mischko Jens , Esderts Alfons 
Published: January 2025

Abstract
New electrical machines for passenger cars are gaining popularity. These electrical machines which contain copper parts need to generate a magnetic field to generate the propulsion of the machine. Laser welding is a fast and an effective joining process for the copper parts. In order to determine the lifetime of the copper parts, it is necessary to assess the fatigue behavior of the laser weld seam. Current guidelines for fatigue assessment do not include copper parts or copper weld seams, hence a fatigue concept must be derived. This proceeding examines the applicability of the notch stress concept with a reference radius of 0.05 mm for copper weld seams and provides a complex and a simplified way of modeling the weld seams. The presented concept takes the geometry of the weld seams and the fracture area surfaces into account. This leads to stress results with a low scatter range and a flat slope of the S-N curve. Furthermore, the results indicate that the notch stresses are transferable.
Association of salivary proteins with dental caries in children with mixed dentition: a systematic review
Authors: Raja M. , Nazzal H. , Cyprian F. S. , Matoug- Elwerfelli M. , Duggal M. 
Published: January 2025

Abstract

Purpose
To review the current evidence on the association between salivary protein profile and dental caries in children during mixed dentition stage.

Methods
This systematic review followed the PRISMA 2020 guidelines. Searches were run in PubMed, Scopus and Embase along with gray literature. The searches were limited to studies on humans, published from inception to February 2024. Observational studies exploring correlations between salivary proteins and caries in children during mixed dentition (6–13 years) were included. The methodological quality of included studies was analyzed independently by two reviewers using the Joanna Briggs checklist and Newcastle–Ottawa scale, respectively followed by a qualitative synthesis.

Results
A total of 17 primary studies were included. The studies recruited 1,330 subjects including 612 caries-active and 505 caries-free subjects. The total protein content was higher in caries-active subjects. Among the glycoproteins, IgA and MUC5B were higher in caries-free subjects while the levels of MUC7 were lower in the caries-free group. Antimicrobial peptides and proteinase-3 levels were also higher in caries-free subjects. Contradictory findings were reported for the association of α- amylase and carbonic anhydrase with caries status. The included studies were categorized as good quality (n = 4), fair quality (n = 12) and poor quality (n = 1).

Conclusion
Based on fair-quality studies included in this review and within its limitations, the findings revealed that salivary proteins may be associated with susceptibility to dental caries in mixed dentition. Total salivary proteins are upregulated in caries-active subjects while salivary IgA, antimicrobial peptides and proteinase-3 are increased in caries-free subjects.

Systematic review registration: The study protocol was registered in PROSPERO (registration number CRD42024517374).
The risk of believing that emotions are bad and uncontrollable: association with orthorexia nervosa
Authors: Vuillier L. , Greville-Harris M. , Moseley R. L. 
Published: January 2025

Abstract

Purpose
This study aimed to explore emotional functioning in individuals with varying levels of orthorexia nervosa (ON) symptoms. Given the established links between emotion dysregulation and other eating disorders (EDs), and the conceptualization of ON within the ED spectrum, this research sought to examine the relationships between ON symptomatology and emotion regulation strategies, alexithymia, and beliefs about emotions.

Methods
A large sample (N = 562) completed self-report measures with high psychometric properties, assessing ON traits (E-DOS), emotion regulation strategies (DERS-SF and ERQ), alexithymia (TAS-20), and beliefs about emotions (ERQ). The study used well-validated measures to address limitations of previous research.

Results
Individuals with high ON traits demonstrated difficulties in most aspects of emotional functioning compared to those with low ON traits. Suppression, but not reappraisal, partially mediated the relationship between beliefs about emotions and ON symptoms. Believing emotions are bad or useless, difficulty controlling impulses, and relying on suppression to regulate emotions were most strongly associated with ON symptoms.

Conclusion
This study provides evidence that emotion dysregulation plays an important role in ON symptomatology. The findings suggest that when emotions feel unhelpful or uncontrollable, and maladaptive strategies like suppression are employed, individuals may seek perceived control through pathologically 'healthy' eating. There is currently no diagnosis criteria for ON, and consequently no clear treatment pathway. Our research suggests that specific aspects of emotional functioning such as beliefs about the usefulness of emotions or difficulties with feeling out of control when upset may be a useful treatment target to help individuals with ON develop healthier coping mechanisms and reduce reliance on rigid dietary rules as a means of emotional regulation.
Level of evidence.
Level III: Evidence obtained from well-designed cohort or case–control analytic studies.
The roles of impulsivity, comorbid ADHD, and borderline personality disorder in patients with bulimia nervosa
Authors: Gilsbach Susanne , Leuchtenberger Julia , Herpertz-Dahlmann Beate , Voderholzer Ulrich , Konrad Kerstin , von Polier Georg , Seitz Jochen , Fichter Manfred 
Published: January 2025

Abstract

Background
Bulimia nervosa (BN) is a serious mental illness with impulsivity as a cardinal symptom. Impulsivity contributes to various other, often comorbid, mental disorders, such as attention deficit/hyperactivity disorder (ADHD) and borderline personality disorder (BPD). The aim of this study was to explore comorbidities of BN with ADHD and BPD as well as the contribution of impulsivity as an underlying trait linking these disorders.

Methods
Hundred and fifteen females with BN and 98 healthy matched controls (HC) (age range between 16 and 48 years) were assessed regarding adult and childhood-ADHD, personality disorders and impulsivity.

Results
Patients with BN were more impulsive (p < 0.001) and more often fulfilled criteria of childhood/adulthood ADHD (p < 0.001) than HC, and criteria of BPD than expected in the general population. Childhood-ADHD (p = 0.009) and BPD (p = 0.017) both were significant positive predictors for impulsivity scores found in patients with BN.

Conclusion
Comorbidity with ADHD and BPD often is prevalent in BN and associated with an increase in impulsivity, the latter being a relevant transdiagnostic trait. It might be beneficial to explore impulsivity as well as comorbidities in the clinical care of patients with BN.

Level of evidence III
Evidence obtained from well-designed cohort or case–control analytic studies.
Screening of primary aldosteronism and pheochromocytoma among patients with hypertension: an Italian nationwide survey
Authors: Monticone Silvia , Goi Jessica , Burrello Jacopo , Di Dalmazi Guido , Cicero Arrigo F. G. , Mancusi Costantino , Moia Elena Coletti , Iaccarino Guido , Veglio Franco , Borghi Claudio , Muiesan Maria L. , Ferri Claudio , Mulatero Paolo ,   Italian Society of Arterial Hypertension (SIIA)
Published: January 2025

Abstract

Purpose
The delayed or missed diagnosis of secondary hypertension contributes to the poor blood pressure control worldwide. This study aimed to assess the diagnostic approach to primary aldosteronism (PA) and pheochromocytoma (PHEO) among Italian centers associated to European and Italian Societies of Hypertension.

Methods
Between July and December 2023, a 10-items questionnaire was administered to experts from 82 centers of 14 Italian regions and to cardiologists from the ARCA (Associazioni Regionali Cardiologi Ambulatoriali) Piemonte. Results were stratified for geographical area, specialty, and center category (excellence vs. non-excellence centers).

Results
Each center diagnosed an average of 2 cases of PA and 0.2 cases of PHEO annually, with higher figures in excellence centers. PA screening is performed mainly in patients with resistant hypertension (73.2%) or hypertension and spontaneous hypokalemia (84.1%), while only 17.1% and 35.4% of centers screen patients with grade 2–3 hypertension. Screening rate is lower for cardiologists compared to other specialists. The main barriers to wider testing were challenges in interpreting the aldosterone/renin ratio under interfering medications and switching to non-interfering drugs. Clinical scores to predict the likelihood of PA and the definition of Standard Operating Procedures were identified as potential tools to boost screening rates. Testing for PHEO was mostly conducted in patients with typical symptoms (75.6%) and/or hypertensive crisis (74.4%). Only 37.8% of centers screened all patients with adrenal incidentaloma.

Conclusion
This study highlights significant gaps in the screening and diagnosis of PA and PHEO across Italian centers and underscores the need for widespread and standardized diagnostic protocols.