bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological impact of additional findings detected by genome-wide Non-Invasive Prenatal Testing (NIPT): TRIDENT-2 study
Authors: Henneman Lidewij , Vliet-Lachotzki Elsbeth van , Martin Linda , Wal Janneke Gitsels - van der , Polak Marike , Bekker Mireille , Galjaard Robert-Jan , Consortium The Dutch NIPT , Bakkeren Iris 
Published: June 2023

Abstract
In the Netherlands, genome-wide non-invasive prenatal testing (NIPT) is offered to all pregnant women as part of the nationwide TRIDENT-2 study. Findings other than trisomy 21, 18 or 13, additional findings, are reported only on request of the pregnant woman. This study examined: 1) women's pre-test perceptions and reasons to opt for additional findings and 2) women's experiences with- and the psychological impact of being informed about an additional finding. A questionnaire, consisting of the anxiety measure State Trait Anxiety Inventory (STAI), distress measure Impact of Event Scale (IES) and questions developed specifically for this study, was retrospectively administered to 402 women who received an additional finding. A total of 227 (56.5%) women completed the questionnaire. Most (60.2%) chose to know additional findings because they wanted as much information as possible about the health of their fetus. Almost all (92%) stated that receiving the additional finding was unexpected, a shock, and/or they were in disbelief, for 85% it caused a lot of worry. Post-test, high anxiety (STAI) levels were reported in 15.5% of women, and 7.5% reported severe distress (IES). Women who gave birth to an affected child (n = 10) experienced most psychological impact (STAI and IES). Eighty-six percent of women with a fetal aberration would opt for additional findings again, compared to 49.2% of women whose result was confined to the placenta. Pre-test counselling should focus on explaining the different results NIPT can generate. Post-test counselling should focus on guiding pregnant women through this uncertain and anxious time.
Physics-informed interpretable machine learning method for DOC monitoring in peripheral milling
Authors: Li Guochao , Jiang Ru , Zheng Hao , Xu Shixian , Sun Li 
Published: June 2023

Abstract
On-line monitoring of DOC (DOC) is an essential way to avoid machining defects, such as over-cutting and machining chatter. Data-driven machine learning algorithm play a principal role to realize the monitor. However, deficient training data and un-interpretable algorithm made it difficult to application. Therefore, a physics-informed interpretable machine learning algorithm was proposed. Firstly, a physics simulation model was established with DOC, rotation speed and feed speed as its inputs and time-domain signals of milling force as its outputs. The output force signals were quantitatively presented by the characteristic values of time domain, frequency domain and waveform parameters. Secondly, six dimensionless characteristics, namely the kurtosis, skewness, waveform factor, peak factor, pulse factor and margin factor of the resultant milling force, were explored through sensitivity analysis method. They were sensitive to DOC but insensitive to milling force coefficient, speed and feed speed. Then, a quantitative relationship model between features and DOC was established by using the least squares linear regression algorithm, which has an intrinsic interpretability. The model was trained by a labeled 100 groups test data. The experiments show that the accuracy of the proposed model for DOC monitoring is greater than 90%.
Fabrication, Design and In-vivo investigation of Mesoporous Silica Based Docetaxel Trihydrate Nanoparticles for Colonic Drug Delivery
Authors: Majumdar Subhabrota , Mondal Mohini , Bose Anirbandeep , Kar Ayan Kumar , Mazumder Rana 
Published: June 2023

Abstract
Background
Mesoporous silica-loaded docetaxel trihydrate nanoparticles are the potential to target drug delivery toward a specific region with high stability and predictable release at the target region. They have large surface areas and mesoporous structures with large pore volumes, leading to high bioavailability and therapeutic efficacy at the disease site. This study demonstrates how nanoparticles can be prepared using an emulsion technique.
Results
The ratios of eudragit S100 to eudragit L100 polymers, along with phosphatidylcholine, were varied according to the response surface methodology. DSC and FTIR studies showed that mesoporous silica particles were successful. All formulations had average particle sizes ranging from 70.65 to 143.01nm, with a range of zeta potential from 17.6 ± 026 to 21 ± 011. In-vitro drug delivery studies were achieved for all formulations with a zeta potential of 17.6 ± 026 to 21 ± 011. After oral administration of the docetaxel, plasma levels were measured in vivo bioavailability testing of docetaxel. Docetaxel nanosuspension had a significantly higher Cmax amount than docetaxel micro-suspension (98.03 ± 23.40 ng/ml and 213.67 ± 72.21 ng/ml, respectively, with tmax 45 minutes). Docetaxel was more bioavailable in nanosuspension formulations, according to a bioavailability test of rats.
Conclusion
The results suggested that the mesoporous silica could be a great potential nanocarrier in colonic delivery with optimal drug content and controlled release docetaxel trihydrate.
Lower-dose Intravenous Immunoglobulin Therapy for Geriatric Inflammatory Bowel Disease Accompanied by COVID-19 Multisystem Inflammatory Syndrome: a Case Report
Authors: ZHANG Peng , ZHAO Wenbin , LIU Juan 
Published: June 2023

Abstract

Background
this article presents a noteworthy case of SARS-CoV-2-associated inflammatory bowel disease (IBD) in an elderly individual who endured three hospitalizations without favorable response to conventional treatment. Ultimately, the patient's symptoms subsided following the administration of intravenous immunoglobulin (IVIg).
Case presentation
: the patient, an elderly individual, experienced short-term fever and sore throat after encountering the COVID-19 pandemic. Despite receiving a three-dose inactivated COVID-19 vaccine, the patient tested positive for SARS-CoV-2 antigen and developed worsening symptoms, including diarrhea and recurrent fever. Initial antibiotic treatment for bacterial enteritis proved ineffective. Further evaluation, including endoscopy and pathology, confirmed the diagnosis of IBD with concurrent multisystem inflammatory syndrome (MIS) in adults. Following lower-dose IVIg administration, the patient's symptoms improved, with resolution of fever, diarrhea, and inflammation.
Conclusions
the case highlights the complexity of diagnosis and treatment in geriatric with IBD and MIS, emphasizing the importance of early intervention with IVIg. Further research is needed to explore the relationship between COVID-19 infection, MIS, and acute autoimmune diseases, as well as the efficacy of IVIg in these conditions.
Evaluation of Antimicrobial usage in Companion Animals at a Tertiary Veterinary Teaching Hospital for Context – Specific interventions in Nigeria
Authors: Adebowale Oluwawemimo , Jimoh Afeez , Adebayo Olufunke , Alamu Aderonke , Adeleye Adenike , Fasanmi Olubunmi Gabriel , olasoju Mary , Soladoye Pius , Fasina Folorunso 
Published: June 2023

Abstract
This study investigated various qualitative and quantitative indices of antimicrobial use in companion animals at a Veterinary Teaching Hospital (VTH-A) and its annex (VTH- B) from 2019-2021. Antimicrobial administrations (AADs) for documented 694 animals was 5, 278 of which 98.8% (5217) and 1.2% (61) were in dogs and cats respectively. At the VTH- A, oxytetracycline (1185 times) was most administered in dogs and metronidazole (26 times) in cats. Similarly, at VTH- B, oxytetracycline was administered 895 times in dogs while amoxicillin was given 7 times in cats. The prescription diversity (PD) was estimated at 0.73 and 0.82 in A and B respectively. Quantity of AMs used was 10.1 Kg (A, 6.2 Kg and B, 3.9 Kg). Oxytetracycline administrations and quantity of metronidazole (P <0.0001) were higher than other AIs. Furthermore, 16.5% of AIs were classified as critically important antibiotics (CIA) with highest priority, while enrofloxacin, ciprofloxacin and azithromycin fell under the World Health Organisation (WHO) Watch group. The In-depth interview (IDI) indicated that the high frequency of oxytetracycline administrations was linked with clinicians’ preference for blood parasites treatment at the hospital. The quantity of metronidazole used was perceived to be higher due to clinician’s preference for treatment of acute gastroenteritis, its wider dose range, and frequency of administration (bi-daily). The study provides a baseline data on antimicrobial use indices in companion animals, for development stewardship and communication training, and policy modifications to enhance antimicrobial therapy optimization in tertiary veterinary hospital care in Nigeria.
Approximate solution to solve non-linear integro-differential type defined using boundary value problems
Authors: HamaRashid Hawsar A. , Hama Mudhafar 
Published: June 2023

Abstract
In this paper, we analyze a boundary value problem (BVP) for a nonlinear integro-Volterra-Fredholm integral equation with variable coefficients. We employ common numerical methods such as the homotopy analysis technique developed by Liao and the modified Adomain decomposition technique to construct an approximate numerical solution. Graphical representations show that these methods are the most efficient and convenient. Additionally, we examine the conditions that guarantee the existence and distinctiveness of the solution for different types of kernels and levels of non-linearity. We provide numerical examples to demonstrate the applicability of our main theorems, and to determine the convergence and accuracy of our proposed technique.
Extraction of capsaicin from Capsicum chinense (cv Bhut Jolokia) using supercritical fluid technology and degradation kinetics
Authors: KSH VIKONO , Anand Vishnu , Rana Virendra Singh , Mishra Jigni , Varghese Eldho , Upadhyay Neelam , Kaur Charanjit 
Published: June 2023

Abstract
Capsaicin (CC), the dominant pungent compound in hot chilies, is widely used as a flavouring agent, preservative, active compound in packaging film and functional foods. Capsicum chinense cv Bhut Jolokia is one of the richest sources of CC, yet scarcely studied. The present investigation aimed to optimize a clean and green method for extracting CC through supercritical fluid extraction (SFE) method. Low-grade, culled, and discarded fruits were used for the extraction, and process was optimized through central composite design of RSM. The optimized extraction condition, 68.31 ℃/347.98 bars/102.50 min, resulted in maximum CC content (367.14 ± 1.12 mg/g) and oleoresin yield (7.23 ± 2.15 %) in a shorter extraction time (< 2 h). Accelerated thermal stability study suggested first-order degradation kinetics of CC at temperatures from 80 to 140 ℃. The activation energy (kJ/mol) of the reaction was 71.86, while Q10 for 80 to 100 ℃, 100 to 120, and 120 to 140 were 0.0548, 0.0574, and 0.1456, respectively. Valorisation of Bhut Jolokia for targeting an oleoresin with maximum CC opens a new window for its commercial exploitation in food industry. Furthermore, the study opens avenues for exploration of SFE-based extraction as clean, and sustainable method with reduced carbon footing.
Drop Set versus Traditional Strength Training Protocols Equated in Volume on Muscle Thickness in Women
Authors: Vilaça-Alves José , Brito João Paulo , Machado Beatriz , Canário-Lemos Rui , Moreira Tiago , Matos Filipe , Peixoto Rafael , Monteiro Gabriéla , Garrido Nuno , Casanova Filipe , Costa Pablo , Reis Victor Machado 
Published: June 2023

Abstract

PurposeThe aim of this study was to investigate the effects of two strength training protocols, equated in volume, on the elbow flexor muscle thickness (MT) in women. Methods Twenty-seven women (mean±sd, age 21.89±2.85 years; stature,167.82±5.90 cm; body mass 63.01±7.20 kg; estimate of body fat mass, 19.19±2.88%) were divided in three experimental groups: a drop-set (DS), a traditional (TR), and a control group (CG). The CG maintained regular strength training without perform any upper body exercises. The participants performed a dumbbell biceps curl for two days per week for 12 weeks 4 sets of 3 blocks of 10 repetitions at 75%, 55%, and 35% of their 1 Repetition Maximum (RM) for the DS group, and 8 sets of 11 repetitions at 75% of the 1RM for the TR protocol. Rest interval between sets was 120 seconds for both groups. The MT was acquired in the anterior face of both upper arms at 50% and 60% of the distance between the lateral epicondyle of the humerus and the acromial process of the scapula before (T0) and after the 24 training sessions (T1).ResultsThere was a significant increase in all MT measurements between T0 and T1for the training groups(p<0.05). In addition, significantly higher values of MT were found in the training groups compared to the control group for all local measurements in T1 (p<0.05). No significant differences were found between training the groups for MT.ConclusionIt appears that both training groups (DS and TR), were effective in promoting MT of the elbow flexors muscles of young women with no differences between training strategies.
Feature pyramid-based convolutional neural network image inpainting
Authors: Wang Shengbo , Wang Xiouyou 
Published: June 2023

Abstract
With the widespread adoption of deep learning-based methods in image processing, they have achieved remarkable results in the challenging task of filling large missing images. However, these methods often produce blurred filling when processing irregularly broken images. The main reason for this phenomenon is that the semantic information of feature maps at different scales cannot effectively complement each other and the underlying information is underutilized. Therefore, we propose a feature pyramid-based network structure. In the first stage, we set the expansion factor to avoid the grid effect during the convolution process and maximize the utilization of the underlying feature map information while increasing the perceptual field. The second stage of the network includes a convolution branch and a feature fusion branch, both of which are parallel structures. The feature fusion branch first samples the feature maps to construct the feature pyramid, and then fuses the feature maps with different resolutions and semantic strengths. Finally, the feature maps are deconvoluted by a decoder to generate images. Our experimental results show that this method produces coherent, clear, visually reasonable recovery areas and excels over other methods in terms of image quality.
Statistics on Gynecologic Cancer in Japan
Authors: Nakai Hidekatsu , Matsumura Noriomi 
Published: June 2023

Abstract
In Japan, high-quality cancer statistics data have been collected through cancer registries, but these data are rarely summarized and reported in research articles. Here, we compiled statistical data on malignant tumors originating from gynecologic organs (ovary, corpus uteri, cervix uteri) in Japan. The number of patients in 2019 was 13,380, 17880, and 10879, respectively, and the number of deaths in 2021 was 5081, 2741, and 2894, respectively. Compared with 40 years ago, the incidence of ovarian cancer has tripled, the incidence of uterine corpus cancer (mainly endometrial cancer) has increased 15-fold, the mortality rate of uterine corpus cancer has tripled, and the incidence of cervical intraepithelial cancer has increased 10-fold in data standardized by the world population. Compared with the United States, the incidence rate of ovarian cancer has overtaken and the mortality rate of uterine corpus cancer is the same, while both the incidence and mortality rates of cervical cancer are higher in Japan. Immediate action is needed in Japan to prevent gynecologic cancers.
Differences in the association of oral health knowledge, attitudes, and practices with frailty among community-dwelling older people in China
Authors: Cao Chenglin , Liao Shengdong , Cao Wenwen , Guo Ying , Hong Zixuan , Ren Bohua , Hu Zhi , Bai Zhongliang 
Published: June 2023

Abstract
Background:
Oral health and frailty are significantly related and should be well examined, especially in late life. Few studies have explored the relationship of oral health knowledge, attitudes, and practices with frailty and examined sociodemographic variations in this association. This study aimed to examine the association between oral health knowledge, attitudes, practices and frailty, with a special focus on comparing differences in their association among the Chinese community-dwelling older population.
Methods:
This study included 4218 community-dwelling older adult (aged ≥ 60 years) who participated in a cross-sectional survey. Sociodemographic characteristics, oral health knowledge, attitudes, practices, and frail status (non-frailty, pre-frailty and frailty) were collected with a face-to-face questionnaire-based interview. Multivariate logistic regression models were used to evaluate the association of oral health knowledge, attitudes, and practices with frailty.
Results:
Of the 4218 participants, 36.2% (n = 1527) and 18.8% (n = 792) were classified as pre-frailty and frailty. Age, gender and educational attainments differences existed in the association of oral health knowledge with frailty. Urban-rural differences in the association of oral health knowledge and practices with frailty were also found. Specifically, oral health knowledge was significantly related to frailty only among participants aged 70–79 years (adjusted odds ratio [95% confidence interval]) (1.08 [1.02–1.15]), females (1.05 [1.00–1.10]), rural residents (1.06 [1.01–1.12]), and those who were primary school and lower education (1.06 [1.01–1.11]), whereas oral health practices were related to frailty only among urban participants (0.96 [0.92–1.00]).
Conclusion:
This study confirmed the different associations of oral health knowledge and practices with frailty among community-dwelling older people in China. Further research is needed to better understand the abovementioned differences and public health strategies are required to improve oral health literacy and thereby contain the development of frailty in later life.
Encoding a magic state with beyond break-even fidelity
Authors: Gupta Riddhi , Sundaresan Neereja , Alexander Thomas , Wood Christopher , Merkel Seth , Healy Michael , Hillenbrand Marius , Wootton James , Jochym-O'Connor Tomas , Yoder Theodore , Cross Andrew , Takita Maika , Brown Benjamin 
Published: June 2023

Abstract
We distill magic states to complete a universal set of fault-tolerant logic gates that is needed for large-scale quantum computing. By encoding better quality input states for our distillation procedure, we can reduce the considerable resource cost of producing magic states. We demonstrate an error-suppressed encoding scheme for a two-qubit input magic state, that we call the CZ state, on an array of superconducting qubits. Using a complete set of projective logical Pauli measurements, that are also tolerant to a single circuit error, we propose a circuit that demonstrates a magic state prepared with infidelity (1.87 ± 0.16) x 10-2. Additionally, the yield of our scheme increases with the use of adaptive circuit elements that are conditioned in real time on mid-circuit measurement outcomes. We find our results are consistent with variations of the experiment, including where we use only post-selection in place of adaptive circuits, and where we interrogate our output state using quantum state tomography on the data qubits of the code. Remarkably, the error-suppressed preparation experiment demonstrates a fidelity exceeding that of the preparation of the same unencoded magic-state on any single pair of physical qubits on the same device.
Randomized Controlled Trial of Liberal vs. Standard Fasting Instructions in Percutaneous Cardiac Procedures
Authors: Atkinson Derek J , Romeiser Jamie L , Almasry Ibrahim O , Tannous Henry J , Parikh Puja B , Bennett-Guerrero Elliott E 
Published: June 2023

Abstract
Background
Pre-procedural fasting to reduce aspiration risk is usual care prior to surgery requiring anesthesia. Prolonged fasting, however, can result in dehydration and may adversely affect patient experience and outcomes. Previous studies suggest that providing a supplemental beverage to patients undergoing cardiac and a variety of other surgical procedures improves patients’ subjective assessment of thirst and hunger and potentially decreases the need for inotrope and vasopressor therapy. Less is known, however, about the effects of ad libitum clear liquids up to 2 hours prior to surgery.
Methods
Adult patients undergoing transcatheter aortic valve replacement (TAVR) or arrhythmia ablation were randomized (1:1) to ad libitum clear liquids up to 2 hours prior to their procedure vs. nil per os (NPO) after midnight (control group, usual care). The primary endpoint was a composite satisfaction score that included patient-reported thirst, hunger, headache, nausea, lightheadedness, and anxiousness prior to surgery. The incidence of case-delay was recorded. Intraoperative vasopressor administration, changes in creatinine, anti-emetic use, and hospital length of stay (LOS) were recorded. Safety endpoints including aspiration were assessed.
Results
A total of 200 patients were randomized and 181 patients were included in the final analysis. Overall, 92% of patients were ASA class III or IV and 23% of patients had NYHA class III or IV symptoms. Groups were well balanced with no significant differences in age, sex or baseline cardiac or renal disease. The composite satisfaction score (primary endpoint) was not significantly different between groups (Ad libitum median = 12, IQR = [6, 17], vs Standard NPO median = 10, IQR = [5, 15], [95% CI = [-1, 4]). No significant differences between the two groups were observed in any of the individual survey questions (thirst, hunger, headache, nausea, lightheadedness, anxiousness). No significant differences between groups were observed for intra-operative vasopressor use, changes in creatinine, rescue anti-emetic use or hospital LOS. There were no case delays attributed to the intervention. There were no cases of suspected aspiration.
Conclusion
No adverse events or case delays were observed in the ad libitum clears group. No significant benefit, however, was observed in patient satisfaction or any of the pre-specified secondary endpoints in patients randomized to ad libitum clear liquids up to 2 hours prior to their procedure.