bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the Effectiveness of Virtual Reality Serious Games in Post-Stroke Rehabilitation: A Novel Evaluation Method
Authors: MASMOUDI Mostefa , Zenati Nadia , Izountar Yousra , Benbelkacem Samir , Haicheur Wassila , Guerroudji Mohamed Amine , Oulefki Adel , Hamitouche Chafiaa 
Published: June 2023

Abstract
Background: This paper presents a novel evaluation method for assessing the effectiveness of virtual reality serious games in post-stroke rehabilitation. Stroke, which is a leading cause of long-term disability, requires effective rehabilitation approaches to facilitate motor recovery and enhance patients’ quality of life. The study aims to investigate the potential benefits of incorporating VR technology into upper limb rehabilitation for post-stroke patients, with a specific focus on evaluating patient motivation and engagement. The proposed evaluation method provides insights into the effectiveness of VR serious games as a rehabilitation tool and contributes to the understanding of their impact on post-stroke recovery.
Methods: This study involved the recruitment of a diverse sample of 20 patients, both male and female, who had experienced left hemiplegia as a result of an ischemic stroke. To ensure a representative sample, patients of different ages were included. Participants were divided into three groups, with each group invited to participate in different stages over a one-year period. During an eight-week period, all groups participated in a rehabilitation program consisting of virtualreality exercises twice a week, alongside five traditional rehabilitation sessions per week. Furthermore, this study introduces a novel approach using camera-based sensors to evaluate patient engagement in virtual reality exercises. By monitoring and analyzing facial expressions throughout each rehabilitation session, our objective is to leverage emotion recognition technology to understand patients’emotional states and levels of motivation and engagement.
Results: The findings from this study indicate that a significant number of patients showed motivation during virtual reality rehabilitation exercises.
Conclusion: The analysis of facial expressions utilizing camera-based sensors, yielded valuable insights into the emotional state and level of engagement exhibited by the participants. These findings substantiate the efficacy of virtual reality as a potent tool in fostering motivation among post-stroke patients, thereby actively involving them in rehabilitation exercises and facilitating their journey toward recovery.
Magmatism Controls Oceanic Transform Fault Topography
Authors: Tian Xiaochuan , Behn Mark , Ito Garrett , Schierjott Jana , Kaus Boris , Popov Anton 
Published: June 2023

Abstract
Oceanic transform faults are fundamental features of plate tectonics, accommodating strike-slip motion between two adjacent mid-ocean ridge spreading segments. The continuations of these faults form tectonically inactive fracture zones, creating the longest ‘scars’ on the Earth’s surface. However, despite the relatively simple kinematic, thermal, and compositional structures of oceanic transform faults and fracture zones, these features display an enigmatic continuum of morphologies ranging from deep valleys to small ridges. Here, through three-dimensional numerical modeling of two mid-ocean ridge segments separated by a transform fault, we find that the rate of magma intrusion within the transform domain exerts a first-order control on transform topography. Low-rate magmatism results in transform-parallel tectonic stretching, generating deep transform valleys and fracture zones. Intermediate-rate magmatism fully accommodates far-field stretching, but strike-slip motion induces across-transform tension, producing shallow valleys whose depth increases with the shear strength of the fault. High-rate magmatism leads to curved plate boundaries and local compression that generates fault-parallel ridges. Thus, the global spectrum of transform topography is controlled by spreading-rate dependent variations in magmatism and can arise without changes of plate motion.
The optimal approximation solution of a constrained dual matrix equation
Authors: Fan Ranran , Yuan Yongxin 
Published: June 2023

Abstract
The solvability conditions and the general solution of the dual matrix equation PX+YG=Q under the linear constraints AX=C and YB=D are deduced by applying the generalized inverse. Furthermore, the corresponding optimal approximate problem is discussed by utilizing the Kronecker product and stretching function. Finally, a numerical example is presented to show the correctness of our results.
MSC Classification: 15A24 , 65F05
Influence of Number Line Approach on Learning Fractions: A Case of Basic Six Learners in the Cape Coast Metropolis
Authors: Sarpong Maxwell Adu , Ntow Forster Danso 
Published: June 2023

Abstract
While the number line approach is successful for fractional learning, there is a dearth of study on its usage in Ghanaian upper primary schools. The study explored the influence of the number line approach on learning fractions. Learners’ achievements, attitudes, and learner’s challenges when using the number line were explored. A quantitative research method embedded with a pretest-posttest non-equivalent design was used. The Fractions Achievement Test (FAT) and a structured questionnaire were the instruments used for data collection. Eighty-one basic six learners with two intact classes (39 in control and 42 experimental groups) were purposively selected within the Cape Coast Metropolis. The experimental group was exposed to learning fractions using the number line, while, in the control group, fraction lessons were carried out through the use of set models. An independent sample t-test was employed to analyse the differences between the pre-test and post-test of the control and experimental group. The findings revealed that there was a significant difference in performance between the post-test scores for the control group (M=7.36, SD=1.78) and the experimental group (M=9.21, SD=2.83); t(69.77)= -3.55; p=0.001 respectively. This implies that the experimental group outperformed the control group due to the influence of the number line approach. Learners in the experimental group had better, understanding, application, and positive attitude toward learning fractions due to the use of number line. Finally, learners however had some challenges, such as the inability to recognise that zero is part of the number system, poor estimation, and counting the tick lines on the number line instead of the intervals between them.
Multifractal Detrended Cross-Correlation Analysis: The case of Brazilian Bioethanol time series
Authors: Fernandes Leonardo HS , Silva José WL , de Araujo Fernando Henrique Antunes , Tabak Benjamin M 
Published: June 2023

Abstract
We have examined the nonlinear cross-correlation between the São Paulo time series of the weekly price of Bioethanol and the other 14 Brazilian capitals’ time series of the weekly price of the same biofuel using the Multifractal Detrended Cross-Correlation Analysis (MFDCCA). We provide evidence of multifractal correlation properties across these prices. We implement our method using both prices and returns and show some divergence between results. We recommend using price time series when using MF-DCCA.
Revisiting post-ICU admission fluid balance across pediatric sepsis mortality risk strata: A secondary analyses from a prospective observational cohort study.
Authors: Atreya Mihir R. , Cvijanovich Natalie Z. , Fitzgerald Julie C. , Weiss Scott L. , Bigham Michael T. , Jain Parag N. , Abulebda Kamal , Lutfi Riad , Nowak Jeffrey , Thomas Neal J. , Baines Torrey , Quasney Michael , Haileselassie Bereketeab , Sahay Rashmi , Zhang Bin , Alder Matthew , Stanski Natalja , Goldstein Stuart 
Published: June 2023

Abstract

Introduction: Post-ICU admission cumulative positive fluid balance (PFB) is associated with increased mortality among critically ill patients. We sought to test whether this risk varied across biomarker-based risk strata upon adjusting for illness severity, presence of severe acute kidney injury (AKI), and use of renal replacement therapy (CRRT) in pediatric septic shock. Design: Ongoing multi-center prospective observational cohort. Setting: Thirteen pediatric ICUs in the United States (2003–2023). Patients: Six hundred and eighty-one children with septic shock. Interventions: None. Measurements and Main Results: Cumulative percent positive fluid balance between day 1–7 (Day 1–7%PFB) was determined. Primary outcome of interest was complicated course defined as death or persistence of ≥ 2 organ dysfunctions by day 7. PERSEVERE-II biomarkers were used to assign mortality probability and categorize patients into high (n = 91), intermediate (n = 134), and low (n = 456) mortality risk strata. Cox proportional hazard regression models with adjustment for PERSEVERE-II mortality probability, presence of sepsis associated acute kidney injury (SA-AKI) on Day 3, and any use of CRRT, demonstrated that time-dependent variable Day 1–7%PFB was independently associated with increased hazard of complicated course in the cohort. Risk stratified analyses revealed that each 10% increase in Day 1–7%PFB was independently associated with increased hazard of complicated course among patients with high mortality risk strata (adj HR of 1.24 (95%CI: 1.08–1.42), p = 0.002), but not among those categorized as intermediate- or low- mortality risk. Conclusions: Our data demonstrate the independent influence of cumulative %PFB on the risk of complicated course. Contrary to our previous report, this risk was largely driven by patients categorized as having a high-mortality risk based on PERSEVERE-II biomarkers. Further research is necessary to determine whether this subset of patients may benefit from targeted deployment of restrictive fluid management or early initiation of de-escalation therapies upon resolution of shock.
Assessment of groundwater and surface water quality in a typical mining community: application of water quality indices and hierarchical cluster analyses
Authors: Anang Emmanuella , Tei Meshack , Antwi Anthony Boakye , Aduboffour Victor Kwabena , Anang Benjamin 
Published: June 2023

Abstract

The rate at which freshwater sources are being contaminated by mining operations in the South-Western part of Ghana is alarming. However, no study has quantified the degree of contamination of the freshwater in such areas, leaving a gap in the literature that requires immediate attention. This study assessed the quality of the surface and groundwater in the Tarkwa Nsuaem Municipality. Even though the physical parameters such as pH and electrical conductivity were indicative of safe freshwater, other parameters such as turbidity, total suspended solids (TSS), dissolved oxygen (DO), and heavy metals in the water sources were high; thus, confirming possible leaching, runoff, and dissolution of the hazardous substances employed in the manganese mining operations. The water quality of 82% of the water sources along the Kawere Stream was low (Classes III and IV). Therefore, the local people are at risk of contracting water-related diseases, and health problems associated with the ingestion of Fe, As, and Mn. The findings in this study are important in establishing the rate at which mining operations are reducing the quality of freshwater in developing countries, and potentially affecting human health.
Economic Evaluation Associated With Clinical-Grade Mobile App–Based Digital Therapeutic Interventions: Systematic Review
Authors: Sapanel Yoann , Tadeo Xavier , Brenna Connor T A , Remus Alexandria , Koerber Florian , Cloutier L Martin , Tremblay Gabriel , Blasiak Agata , Hardesty Chris L , Yoong Joanne , Ho Dean 
Published: June 2023

Background
Digital therapeutics (DTx), a class of software-based clinical interventions, are promising new technologies that can potentially prevent, manage, or treat a spectrum of medical disorders and diseases as well as deliver unprecedented portability for patients and scalability for health care providers. Their adoption and implementation were accelerated by the need for remote care during the COVID-19 pandemic, and awareness about their utility has rapidly grown among providers, payers, and regulators. Despite this, relatively little is known about the capacity of DTx to provide economic value in care.

Objective
This study aimed to systematically review and summarize the published evidence regarding the cost-effectiveness of clinical-grade mobile app–based DTx and explore the factors affecting such evaluations.

Methods
A systematic review of economic evaluations of clinical-grade mobile app–based DTx was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 guidelines. Major electronic databases, including PubMed, Cochrane Library, and Web of Science, were searched for eligible studies published from inception to October 28, 2022. Two independent reviewers evaluated the eligibility of all the retrieved articles for inclusion in the review. Methodological quality and risk of bias were assessed for each included study.

Results
A total of 18 studies were included in this review. Of the 18 studies, 7 (39%) were nonrandomized study–based economic evaluations, 6 (33%) were model-based evaluations, and 5 (28%) were randomized clinical trial–based evaluations. The DTx intervention subject to assessment was found to be cost-effective in 12 (67%) studies, cost saving in 5 (28%) studies, and cost-effective in 1 (6%) study in only 1 of the 3 countries where it was being deployed in the final study. Qualitative deficiencies in methodology and substantial potential for bias, including risks of performance bias and selection bias in participant recruitment, were identified in several included studies.

Conclusions
This systematic review supports the thesis that DTx interventions offer potential economic benefits. However, DTx economic analyses conducted to date exhibit important methodological shortcomings that must be addressed in future evaluations to reduce the uncertainty surrounding the widespread adoption of DTx interventions.

Trial Registration
PROSPERO International Prospective Register of Systematic Reviews CRD42022358616; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022358616
Tạo dòng, biểu hiện kháng nguyên F18 dung hợp peptide định hướng tế bào M
Authors: Mai Quốc Gia , Nguyễn Thị Phương Thảo , Trần Văn Hiếu 
Published: June 2023

Tiêm mao F18 đóng vai trò quan trọng giúp Enterotoxigenic Escherichia coli (ETEC) bám vào ruột và tiết độc tố gây bệnh tiêu chảy heo con sau cai sữa (post-weaning diarrhea, PWD). Vaccine là một cách thức hữu hiệu, kinh tế và khả thi giúp phòng chống ETEC trên heo. Việc phát triển vaccine uống, tạo miễn dịch niêm mạc thông qua nhắm trúng đích tế bào M đang được quan tâm. Nhiều nghiên cứu cho thấy Hsp60 có khả năng tương tác với PrPC trên bề mặt tế bào M. Dựa trên cấu trúc của Hsp60 và tin sinh học, peptide PEP được dự đoán có khả năng tương tác với thụ thể PrPC. Vector pET22b-pep-f18 được cấu trúc bằng cách thế gene gfp trong vector pET22b‑pep‑gfp bằng gene f18. Sau khi xử lí với cặp enzyme cắt hạn chế XhoI và BamHI, gene f18 và vector pET22b‑pep‑gfp được nối với nhau bằng T4 DNA Ligase. Vector pET22b‑pep-f18 được hóa biến nạp vào chủng vi khuẩn E. coli BL21(DE3), cảm ứng biểu hiện với IPTG 0,5 mM. Sự biểu hiện của protein PEP‑GFP được kiểm tra bằng điện di SDS-PAGE, nhuộm Coomassie Blue và Western blot với kháng thể kháng 6xHis. Cuối cùng, protein PEP‑F18 được tinh sạch bằng sắc ký ái lực ion kim loại (IMAC). Kết quả cho thấy vector pET22b‑pep-f18 đã được tạo thành công. Protein PEP‑F18 được thu nhận, tinh sạch với độ tinh sạch cao...
Thủ pháp dòng ý thức trong tiểu thuyết Một ví dụ xoàng của Nguyễn Bình Phương từ góc nhìn chủ nghĩa hiện đại
Authors: Lê Hoàng Ngọc Thái , Lê Thị Nhiên , Lưu Thị Khánh Vy 
Published: June 2023

Bài viết trình bày nghiên cứu về giá trị của tổ chức trần thuật và nghệ thuật xây dựng nhân vật bằng thủ pháp dòng ý thức trong tiểu thuyết Một ví dụ xoàng của Nguyễn Bình Phương. Với thủ pháp này, tác giả đã thể hiện khả năng tái hiện những tâm trạng, cảm xúc và thế giới nội tâm nhân vật. Bên cạnh đó, nghệ thuật xây dựng nhân vật đã tạo nên hình tượng nhân vật mới mẻ và độc đáo thông qua sự mờ hoá và tập trung vào quá trình tâm lí. Qua đó, Nguyễn Bình Phương đã thể hiện sự tiếp thu và sáng tạo khi vận dụng biểu hiện của Chủ nghĩa hiện đại trong sáng tác.
Улуг битикчи — тюрко-монгольский институт, интегрированный в систему мусульманской администрации чингизидских государств XIII–XIV вв. (по материалам «Дастур ал-катиб»)
Authors:   Kazan (Volga Region) Federal University (44, Levo-Bulachnaya St., 420111 Kazan, Russian Federation), Abzalov Lenar F. , Gatin Marat S. , Mustakimov Ilyas A. , Pochekaev Roman Yu.  ,   L. N. Gumilyov Eurasian National University (2, Satpayev St., 010000 Nur-Sultan, Republic of Kazakhstan),   National Research University Higher School of Economics (3, Kantemirovskaya St., 194100 St. Petersburg, Russian Federation)
Published: June 2023

Introduction. The article examines a yarliq from the medieval Persian treatise Dastur al-Katib to characterize the institution of ulug bitigchi that used to be widespread in the Mongol Empire and states of Genghis Khan’s descendants. Goals. The study attempts an interdisciplinary analysis of the historical monument — one yarliq appointing an ulug bitigchi (head of scribes) and contained in Dastur al-Katib fi Tayin al-Maratib (A Scribe’s Guide to Determining Ranks) compiled in the mid-14th century by Persian official Muhammad ibn Hindushah Nakhchivani. Materials and methods. The paper focuses on Dastur al-Katib and the mentioned yarliq proper, involves related medieval sources on Mongol Iran and other Chinggisid states, including works by Juvayni, Rashid al-Din, Fasih Khwafi, etc., official documents of the Chinggisid chancelleries. The work employs a series of historical and legal research methods, such as those of source criticism, diplomatics analysis, comparative historical research, formal legal approach, historical legal and comparative legal analyses. Results. The paper introduces the yarliq appointing an ulug bitigchi from the medieval Persian treatise Dastur al-Katib into Russian-language scientific discourse and supplements it with a detailed interdisciplinary analysis. The work clarifies specific features of an ulug bitigchi’s legal status — including his functions, rights, requirements for candidates in Chinggisid chance­lleries — and traces its evolution. It also shows reasons for the survival of the institution in those states even after the official conversion to Islam and shaping of a corresponding government system in accordance with traditions that had existed across the Volga Region, Iran and Central Asia long before the Mongol conquest. Conclusions. The fact that the institution of ulug bitigchi did survive the subsequent Islamization was to primarily position of Ilkhans as heirs of the Mongol Empire where it had first been established as well as to seek a compromised approach in governing their various subjects — nomadic and sedentary peoples, Turko-Mongols and those who spoke Iranian languages, Moslems and adherents of other religions.
Un argumento transcendental para un tecnofeminismo localizado
Authors: Guzmán Olmos Ana María 
Published: June 2023

El xenofeminismo es un proyecto de acción tecnofeminista opuesto a toda forma de naturalismo local cuya propuesta está basada en la idea de una subjetividad ilimitada. Por otra parte, las epistemologías feministas —específicamente me refiero a la postura de Donna Haraway— argumentan que es necesario afirmar la localidad del conocimiento para evitar la producción de ciencia y tecnologías sexistas. En este texto reviso los supuestos que subyacen a esta supuesta dicotomía. Afirmo que la discusión al fondo de la dicotomía gira en torno a la idea de sustancias o tipos naturales. De acuerdo con este debate, asumir una posición de feminismo localizado implica estar en contra de cualquier argumento naturalista. Para defender esta idea recurro a la forma del argumento trascendental en el contexto de la filosofía tardía de F. W. J. Schelling. Con base en la crítica del naturalismo transcendental de Iain Hamilton Grant, defiendo la necesidad de una subjetividad localizada. Afirmo que no es necesario ser esencialista biologicista para afirmar la necesidad de un pensamiento tecnofeminista situado, así como que no toda crítica al pensamiento localizado debe afirmar una subjetividad ilimitada. Al final de este texto apunto hacia la posibilidad de un argumento trascendental para la necesidad de un tecnofeminismo localizado.
Molecular markers associated with response to vaccination against Porcine Reproductive and Respiratory Syndrome virus in a commercial swine farm from southern Sonora
Authors: Quiñones-Chayrez Kathya Michelle , Luna-Nevárez Guillermo , Thomas Milton G. , Enns R. Mark , Speidel Scott E. , Zeng Xi , Sánchez-Castro Miguel Ángel , Aguilar-Trejo Carlos Martín , Hernández-Chávez Juan Francisco , Luna-Nevárez Pablo 
Published: June 2023

Porcine Reproductive and Respiratory Syndrome (PRRS) is a viral disease that seriously affects the swine industry. The main method of control is vaccination, which has shown variable effectiveness partly attributed to genetic variability in sows. The objective was to validate single-nucleotide polymorphisms (SNPs) associated with performance traits following PRRS vaccination in replacement sows. A population of 100 Landrace(¾) / Yorkshire(¼) commercial line sows of 6 months of age, an average weight of 108 kg, and negative for PRRS virus were used. After an acclimatization stage, sows were vaccinated against PRRS (day 0). Daily weight gain (DWG) and rectal temperature (RT) were recorded on days 0, 7, 14, 21, and 28. A blood sample was individually collected on day 40 and used for DNA extraction and genotyping of 59 SNPs. These SNPs were previously identified through genomic analysis as associated with a vaccination response indicator. The 59 SNPs were validated in this study using a statistical mixed-effects model that included DWG or RT as response variables. From 59 SNPs, 5 of them were associated with DWG (P < 0.05), and 3 with RT (P < 0.05). Interestingly, the SNPs in the genes DENND5A (rs81409931 and rs81216494) and COL22A1 (rs329119519 and rs81381462) were associated with both DWG and RT, and they showed a higher allele contribution effect on phenotypes. These 2 genes appeared to be functionally related to DWG; therefore, their corresponding 4 SNPs are proposed as genetic markers associated with the response to PRRS vaccination in replacement sows from southern Sonora.