bluuebunny/crossref_metadata_2025_split huggingface dataset:
The associations between public stigma and support for others’ help-seeking for alcohol use disorder: a cross sectional study in the general Danish population
Authors: Wallhed Finn Sara , Mejldal Anna , Nielsen Anette Søgaard 
Published: August 2023

Abstract
Background
A minority of all individuals with alcohol use disorders (AUD) seek treatment, where stigma is one prominent barrier. Social support is important to facilitate health and increase treatment-seeking. Whether there is an association between stigma and attitudes towards others’ help-seeking for AUD is unknown. The aim of this study was to investigate the associations between stigma and support towards others’ help-seeking for AUD, also to explore possible gender differences.

Method
Cross-sectional study, n = 2895, including Danish adults aged 30–65 in the general population. Year 2020, an online questionnaire was administrated, which covered demographics, attitudes towards others’ help-seeking for AUD, and stigma measured with the Difference, Disdain & Blame Scales. Analyses were performed with Restricted Cubic Spline models, and odds ratios were calculated.

Results
Lower level of stigma was associated with a higher probability for endorsing an “active support strategy”. Level of stigma was not associated with “not knowing what to say or do” or “sharing my concern with others”. There were few gender differences: among men, higher level of stigma was associated with a higher probability of “avoidance”. Among women, lower level of stigma was associated with a lower probability of “avoidance”.

Conclusion
There is a clear association between stigma and attitudes towards supporting others’ help-seeking for AUD. The results highlight the need to reduce stigma and promote engagement towards others’ treatment-seeking.
Brain–computer interface: trend, challenges, and threats
Authors: Maiseli Baraka , Abdalla Abdi T. , Massawe Libe V. , Mbise Mercy , Mkocha Khadija , Nassor Nassor Ally , Ismail Moses , Michael James , Kimambo Samwel 
Published: August 2023

AbstractBrain–computer interface (BCI), an emerging technology that facilitates communication between brain and computer, has attracted a great deal of research in recent years. Researchers provide experimental results demonstrating that BCI can restore the capabilities of physically challenged people, hence improving the quality of their lives. BCI has revolutionized and positively impacted several industries, including entertainment and gaming, automation and control, education, neuromarketing, and neuroergonomics. Notwithstanding its broad range of applications, the global trend of BCI remains lightly discussed in the literature. Understanding the trend may inform researchers and practitioners on the direction of the field, and on where they should invest their efforts more. Noting this significance, we have analyzed 25,336 metadata of BCI publications from Scopus to determine advancement of the field. The analysis shows an exponential growth of BCI publications in China from 2019 onwards, exceeding those from the United States that started to decline during the same period. Implications and reasons for this trend are discussed. Furthermore, we have extensively discussed challenges and threats limiting exploitation of BCI capabilities. A typical BCI architecture is hypothesized to address two prominent BCI threats, privacy and security, as an attempt to make the technology commercially viable to the society.
The functional relevance of visuospatial processing speed across the lifespan
Authors: Aul Courtney , Brau Julia M. , Sugarman Alexander , DeGutis Joseph M. , Germine Laura T. , Esterman Michael , McGlinchey Regina E. , Fortenbaugh Francesca C. 
Published: August 2023

AbstractVisuospatial processing speed underlies several cognitive functions critical for successful completion of everyday tasks, including driving and walking. While it is widely accepted that visuospatial processing speed peaks in early adulthood, performance across the lifespan remains incompletely characterized. Additionally, there remains a lack of paradigms available to assess visuospatial processing speed in unsupervised web-based testing environments. To address these gaps, we developed a novel visuospatial processing speed (VIPS) task adapted from two tests sensitive to visuospatial processing speed declines in older adults, the Useful Field of View paradigm and the PERformance CEntered Portable Test. The VIPS task requires participants to make a central orientation discrimination and complete a simultaneous peripheral visual search task. Data were collected from 86 in-lab volunteers (18–30 years) to compare performance to traditional neuropsychological measures. Consistent with previous literature, performance on the novel VIPS task significantly correlated with measures of selective attention, executive functioning, visual speed, and working memory. An additional 4395 volunteers (12–62 years) were recruited on TestMyBrain.org to establish lifespan trajectories of visuospatial processing speed and associations with functional disability. VIPS task performance peaked in the early 20’s, and steadily decreased such that thresholds doubled in 60-year-olds relative to 20-year-olds (817 ms vs. 412 ms). VIPS task performance significantly correlated with self-reported cognitive functioning deficits broadly across the lifespan but was specifically related to mobility issues in middle-age. These findings have important implications for early detection of cognitive decline and provide insights into potential early intervention targets for younger and middle-aged adults.
Digital pathology in Latin America
Authors: García-Rivello Hernán , Cancio Alfredo , Monroy Ana Maria Vanegas , Soares Fernando Augusto , García Franco Doimi , Puyol Jorge Ugalde , Schultz Marcela , Díaz Nicolás Vivar , Zoroquiain Pablo , Soria-Céspedes Danny 
Published: August 2023

AbstractDigital pathology (DP) adoption in Latin America has expanded slower than in developed regions, probably due to many barriers not seen in the latter areas. This article aims to present the current scenario in the region, highlighting barriers and possible solutions to encourage its adoption in Latin American countries.Methods An expert panel of 9 Latin American medical pathologists and 1 information technology specialist participated in an online modified Delphi panel, utilizing a third-party platform (iAdvise, Within3, USA). Thirteen pre-prepared questions were answered interactively.Results Experts' observations confirm the paucity of labs in the region that utilize digital pathology technology. The panel ranked obtaining second opinions and presenting images remotely as the main benefit of a digital pathology system, although many others were cited as well. Cost of implantation was the main barrier mentioned by the experts. Payers' and decision makers' lack of awareness of benefits ranked second as a barrier to DP implementation. Internet infrastructure was also mentioned as a concerning issue in the region. Besides diagnostic pathology services, proposed revenue incomes included commercialization of digital services to other institutions, loan agreements of equipment and software, and organizing courses for pathologists or residents. The need for alternative reimbursement methods for diagnostic services was also mentioned. A regional network of collaborating institutions was also suggested as a viable solution to reach distant areas and laboratories lacking the technology.Conclusions The benefits of DP are clear to the expert panel, but cost and lack of awareness of its benefit may be hampering its widespread adoption in Latin America.
Functional improvement of synbiotic yogurt enriched with Lacticaseibacillus rhamnosus and aloe vera gel using the response surface method
Authors: Ahmed Sadia , Noor Asia , Tariq Muhammad , Zaidi Arsalan 
Published: August 2023

AbstractThe response surface technique was applied to produce synbiotic yogurt containing Lacticaseibacillus rhamnosus and aloe vera gel (AVG) with high functionality (antioxidant and antimicrobial characters), superior physicochemical properties, and desirable sensory attributes. The experiments were planned around a central composite design (CCD) with two independent variables: AVG concentration (0–5%, w/w) and storage time (1–28 days). The AVG concentration and storage time significantly improved the viability of L. rhamnosus up to 7.9 cfu/g during the shelf life which is a practical limit for a probiotic. It enhanced the yogurt’s antioxidant and antipathogenic activity, proteolytic content, water-holding capacity, and sensory aspects. High concentrations of AVG reduced the yogurt’s desirable textural aspects (hardness and gumminess) except for firmness and adhesiveness and to some degree the sensory properties as well. The results showed that adding 5% AVG to probiotic yogurt produced a functional food with 68% desirability that retained its beneficial properties for at least 14 days under refrigerated storage.
Graphical Abstract
Distinct role of TGN-resident clathrin adaptors for Vps21p activation in the TGN–endosome trafficking pathway
Authors: Nagano Makoto , Aoshima Kaito , Shimamura Hiroki , Siekhaus Daria Elisabeth , Toshima Junko Y. , Toshima Jiro 
Published: August 2023

ABSTRACT
Clathrin-mediated vesicle trafficking plays central roles in post-Golgi transport. In yeast (Saccharomyces cerevisiae), the AP-1 complex and GGA adaptors are predicted to generate distinct transport vesicles at the trans-Golgi network (TGN), and the epsin-related proteins Ent3p and Ent5p (collectively Ent3p/5p) act as accessories for these adaptors. Recently, we showed that vesicle transport from the TGN is crucial for yeast Rab5 (Vps21p)-mediated endosome formation, and that Ent3p/5p are crucial for this process, whereas AP-1 and GGA adaptors are dispensable. However, these observations were incompatible with previous studies showing that these adaptors are required for Ent3p/5p recruitment to the TGN, and thus the overall mechanism responsible for regulation of Vps21p activity remains ambiguous. Here, we investigated the functional relationships between clathrin adaptors in post-Golgi-mediated Vps21p activation. We show that AP-1 disruption in the ent3Δ5Δ mutant impaired transport of the Vps21p guanine nucleotide exchange factor Vps9p transport to the Vps21p compartment and severely reduced Vps21p activity. Additionally, GGA adaptors, the phosphatidylinositol-4-kinase Pik1p and Rab11 GTPases Ypt31p and Ypt32p were found to have partially overlapping functions for recruitment of AP-1 and Ent3p/5p to the TGN. These findings suggest a distinct role of clathrin adaptors for Vps21p activation in the TGN–endosome trafficking pathway.
Ethnic and religious identities in Russian penal institutions: A case study of Uzbek Transnational Muslim prisoners
Authors: Urinboyev Rustamjon , Pallot Judith 
Published: August 2023

Russia has become one of the main migration hubs worldwide following the collapse of the Soviet Union. The vast majority of migrant workers travel to Russia from three Central Asian countries. However, Russian immigration laws and policies are ambiguous and highly punitive. The result is that many migrants resort to undocumented status working in the shadow economy, which places them in a disadvantaged and precarious position. In this position they are vulnerable to becoming targets of the Russian criminal justice system as they take to crime to overcome economic uncertainty, become embroiled in interpersonal conflicts ending in violence, or fall victim to fabricated criminal charges initiated by Russian police officers under pressure to produce their monthly quota of arrests. The impact on Russian penal institutions is that they have become ethnically, culturally, and religiously diverse sites as a consequence of the incarceration of growing numbers of transnational prisoners. Using person-to-person interviews conducted in Uzbekistan with men and women who served sentences in Russian penal institutions during the past two decades, we show in this article how the large-scale migratory processes have transformed Russian prisons into sites of ethnic and religious plurality, in which formal rules and informal sub-cultures - the colony regime, so-called thieves' law (vorovskoy zakon), ethnic solidarity norms, and Sharia law - coexist and clash in new ways compared with the status quo ante. Thus, we argue there is a need to revise the prevailing understanding about the power dynamics in Russian penal institutions. Our findings undermine the prison service's insistence of the ethnic and ethno-religious neutrality and cosmopolitanism of Russian penal space, which is presented as a latter-day manifestation of the Soviet-era 'friendship of nations' policy. Russian prisons today must be understood as sites of ethnic and religious pluralism.
Five-year outcomes of immediate implant placement for mandibular molars with and without chronic apical periodontitis: A retrospective study
Authors: Yang Hua , Luo Dan , Yuan Mu-Jie , Yang Jian-Jun , Wang Da-Shan 
Published: August 2023

BACKGROUND
Most physicians consider molars with chronic apical periodontitis (CAP) lesions as contraindications for immediate implant placement. At the patient’s request, we perform immediate implant placement of the mandibular molars with CAP in clinical practice.
AIM
To retrospectively analyze and compare the 5-year outcomes of immediate implant placement of the mandibular molars with CAP and those without obvious inflammation.
METHODS
The clinical data of patients with immediate implant placement of the mandibular molars in the Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University, from June 2015 to June 2017 were collected. The patients were divided into CAP (n = 52) and no-CAP (n = 45) groups. Changes in bone mineral density and bone mass around implants were analyzed 5 years after implant restoration.
RESULTS
At 5 years after implantation, the peri-implant bone mineral density was 528.2 ± 78.8 Hounsfield unit (HU) in the CAP group and 562.6 ± 82.9 HU in the no-CAP group (P = 0.126). Marginal bone resorption around implants did not differ significantly between the two groups, including buccal (P = 0.268) or lingual (P = 0.526) resorption in the vertical direction or buccal (P = 0.428) or lingual (P = 0.560) resorption in the horizontal direction. Changes in the peri-implant jump space did not differ significantly between the two groups, including the buccal (P = 0.247) or lingual (P = 0.604) space in the vertical direction or buccal (P = 0.527) or lingual (P = 0.707) space in the horizontal direction. The gray value of cone-beam computed tomography measured using Image J software can reflect the bone mineral density. In the CAP area, the gray values of the bone tissue immediately and 5 years after implant placement differed significantly from those of the surrounding bone tissue (P < 0.01).
CONCLUSION
The results of this study suggest that immediate implant placement of the mandibular molars with CAP can achieve satisfactory 5-year clinical results, without significant differences in the complications, survival rate, or bone tissue condition from the no-CAP mandibular molars.
Diabetic neuropathy results in vasomotor dysfunction of medium sized peripheral arteries
Authors: Ege Fahrettin , Kazci Ömer , Aydin Sonay 
Published: August 2023

BACKGROUND
The effect of the sympathetic nervous system on peripheral arteries causes vasoconstriction when smooth muscle cells in the walls of blood vessels contract, which leads to narrowing of arteries and reduction of the blood flow.
AIM
To compare sympathetic vasomotor activation of the brachial arteries in healthy subjects and patients with painful diabetic neuropathy; and therefore, to assess whether there is significant vasomotor dysfunction of medium sized arteries in diabetic neuropathy.
METHODS
The study included 41 diabetic neuropathy patients and 41 healthy controls. Baseline diameter and flow rate of the brachial arteries were measured. Then, using a bipolar stimulus electrode, a 10 mA, 1 Hz electrical stimulus was administered to the median nerve at the wrist level for 5 s. The brachial artery diameter and blood flow rate were re-measured after stimulation.
RESULTS
In the control group, the median flow rate was 70.0 mL/min prior to stimulation and 35.0 mL/min after stimulation, with a statistically significant decrease (P < 0.001), which is consistent with sympathetic nervous system functioning (vasoconstriction). In the diabetic neuropathy group, median flow rate before the stimulation was 35.0 mL/min. After stimulation, the median flow rate was 77.0 mL/min; thus, no significant decrease in the flow rate was detected. In the control group, the median brachial artery diameter, which was 3.6 mm prior to stimulation, decreased to 3.4 mm after stimulation, and this decrease was also statistically significant (P = 0.046). In the diabetic neuropathy group, the median brachial artery diameter increased from 3.4 mm to 3.6 mm following nerve stimulation. Once again, no narrowing was observed.
CONCLUSION
Our research suggests that diabetic neuropathy results in significant vasomotor dysfunction of medium sized peripheral arteries. Physiological vasoconstriction in response to sympathetic activation is impaired in diabetic neuropathy.
Zimberelimab plus chemotherapy as the first-line treatment of malignant peritoneal mesothelioma: A case report and review of literature
Authors: Peng Xiao-Dong , You Zhen-Yu , He Lian-Xiang , Deng Qi 
Published: August 2023

BACKGROUND
Malignant peritoneal mesothelioma (MPeM) is a rare cancer with a poor prognosis at advanced stage, and the standard first-line treatment for inoperable patients is chemotherapy. Although combining programmed cell death 1 (PD-1) inhibitors with chemotherapy is generally considered safe and effective in several malignant solid tumors, there are few reports regarding initial immunochemotherapy in advanced MPeM.
CASE SUMMARY
Here, to our knowledge, we present the first case of a patient with epithelioid subtype MPeM, who was treatment-naïve and benefited from initial PD-1 inhibitor plus standard chemotherapy with a prolonged progression-free survival (PFS) and good tolerance. A 49-year-old man was admitted to our hospital for a persistent burning sensation in the abdomen. Computed tomography revealed a solid mass in the lower abdomen, which was subsequently diagnosed histologically as epithelioid subtype MPeM by core needle biopsy. The patient received eight cycles of pemetrexed 800 mg (day 1), cisplatin 60/50 mg (day 1–2), and zimberelimab (PD-1 inhibitor) 240 mg (day 1) every 3 wk. He achieved significant reduction of peritoneal tumors with remarkable improvement in symptoms. The best tumor response was partial remission with a final PFS of 7 mo. No immune-related adverse event occurred during the combination treatment.
CONCLUSION
The outcome of the present case demonstrates the promising anti-tumor activity of immunochemotherapy to treat inoperable MPeM in the future.
TINAVI robot-assisted one-stage anteroposterior surgery in lateral position for severe thoracolumbar fracture dislocation: A case report
Authors: Ye Sen , Chen Yan-Zhen , Zhong Ling-Jian , Yu Chang-Zhang , Zhang Han-Kun , Hong Yang 
Published: August 2023

BACKGROUND
The combined anterior/posterior approach appears to be capable of reconstructing spinal stability, correcting thoracolumbar deformity, and promoting neural recovery in severe thoracolumbar fracture dislocation. However, this type of operation requires changing the body position during the procedure, resulting in a lengthy operation time. As a universal surgical robot, TINAVI robot has achieved good surgical results in clinical surgery. But to our knowledge, no reports describing TINAVI robot-assisted single lateral position anteroposterior surgery for thoracolumbar fracture dislocation.
CASE SUMMARY
We describe a case of a 16-year-old female patient with severe thoracolumbar fracture and dislocation underwent surgery assisted by the TINAVI robot. A one-stage combined anterior and posterior operation was performed on a severe thoracolumbar fracture dislocation using the TINAVI robot, and the operation was completed in right lateral position.
CONCLUSION
The TINAVI robot-assisted one-stage anterior and posterior surgery in right lateral position for severe thoracolumbar fracture and dislocation is both safe and effective.
Individual with concurrent chest wall tuberculosis and triple-negative essential thrombocythemia: A case report
Authors: Xu Xiao-Yan , Yang Yong-Bin , Yuan Jun , Zhang Xiao-Xia , Kang Lin , Ma Xiang-Shu , Yang Jie 
Published: August 2023

BACKGROUND
Chest wall tuberculosis (TB) and triple-negative essential thrombocythemia (TN-ET) are rare medical conditions, and their combination is extremely rare globally. Only one case of TB peritonitis with thrombocytosis has been reported, which was identified in 1974.
CASE SUMMARY
Herein, we report the case of a 23-year-old man with concurrent chest wall mass and TN-ET. The patient presented to a local hospital due to having a headache and low-grade fever for 2 d, with their bodily temperature fluctuating at around 36.8 °C. Hematological analysis showed a high platelet count of 1503 × 109/L. Subsequently, the patient visited our hospital for further investigation. Computed tomography of the chest suggested a submural soft tissue density shadow in the left lower chest wall. After surgical resection, the pathological findings of the swelling were reported as TB with massive caseous necrosis. According to the World Health Organization diagnostic criteria, the patient was diagnosed with TN-ET, as they met the requirement of four main criteria or the first three main criteria and one secondary criterion. The patient was eventually diagnosed with chest wall TB with TN-ET, which is extremely rare.
CONCLUSION
Chest wall TB is rare. TN-ET diagnosis requires secondary factor exclusion and satisfaction of primary diagnostic criteria. miRNA, combined with the methylation process, could explain suppressor of cytokine signaling (SOCS) 1 and SOCS3 downregulation in ET-JAK2V617F-negative patients. The miRNA could participate in JAK2 pathway activation. SOCS3 may be a novel MPN biomarker.
Self-strangulation induced penile partial amputation: A case report
Authors: Maimaitiming A-Bu-Lai-Ti , Mulati Ye-Li-Su-Dan , Apizi Ai-Re-Ti , Li Xiao-Dong 
Published: August 2023

BACKGROUND
Traumatic amputation of the penis is a rare surgical emergency, usually caused by self-mutilation, accidents, circumcision, assault and animal attacks. This study aimed to summarize our treatment experience involving penile reconstruction in a rare case of a self-strangulation induced chronical penile partial amputation.
CASE SUMMARY
A 22-year-old man presented with self-strangulation induced chronical penile partial amputation for 3 mo where the penile proximal part was 1 cm far from the pubis. Reconstruction methods included end-to-end anastomosis of the urethral mucosa, proximal anastomosis of the corpus cavernosum and tunica albuginea of the penis, anastomosis of the deep dorsal vein, dorsal artery, and superficial dorsal vein. Patient urinated smoothly after the catheter was removed on day 21. 3 mo after the surgery, the patient's penile preliminary cosmetic appearance was satisfactory, with occasional morning erections. Distal penile sensation was preserved, yet erection hardness of the distal penis was not satisfactory.
CONCLUSION
Complete preoperative assessment and prompt surgical intervention decreases loss of residual penile functions.