bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the dynamic coupled coordination and influencing factors of the digital economy, energy and human habitat in Western China
Authors: Li Shiwu , Yang He , Huang Wei , Yang Hao 
Published: January 2025

Purpose
This study aims to explore the spatio-temporal dynamic characteristics and influencing factors of the coordination degree of the three systems of digital economy, energy and human habitat in Western China and to provide academic research support for promoting coordinated and sustainable development in similar regions of the world.

Design/methodology/approach
Based on system theory and sustainable development theory, this study primarily uses the coupled coordination degree model to assess the degree of coordination between the three systems.

Findings
The findings of this study indicate that: The three systems’ overall coordination is low. The distribution of the degree of coordination has spatial differences and its coefficient of variation is small. The probability of the coordination type changing for the better is greater than that of the opposite, and neighboring provinces interact with one another. The old-age dependence ratio, the resident population’s urbanization rate and public budget expenditure have the strongest gray association with the degree of coordination.

Practical implications
This study’s findings will be valuable for policymakers in developing policies to promote the coordinated and sustainable growth of the region’s digital economy, energy and human habitat. Additionally, the findings will aid in facilitating regional exchanges and cooperation to enhance the level of sustainable development.

Social implications
This study’s findings will contribute to increased social interest in coordinating sustainable growth in the digital economy, energy and human habitat.

Originality/value
This study examines the digital economy, energy and human habitat within the same framework and investigates spatial spillover effects using spatial Markov chains.
Association of statins, gliptins, and antipsychotics with bullous pemphigoid: A case–control study in the Cretan population
Authors: Kavvalou Eirini , Krasagakis Konstantinos , Chlouverakis Gregory , Xekouki Paraskevi , Daraki Vasiliki , Kouvidou Charikleia , Lagoudaki Eleni , Krüger‐Krasagakis Sabine‐Elke 
Published: January 2025

AbstractBullous pemphigoid (BP) is an autoimmune blistering disorder predominantly affecting the elderly. Recently, many studies have shed light on the effect of specific drug intake and comorbidities on the development of BP. The purpose of this study was to investigate the association of specific drug class intake and comorbidities with the development of BP in the Cretan population. Significant associations with BP were found for statins (odds ratio [OR] = 4.06, 95% confidence interval [CI] 1.99–8.27, P < 0.001), gliptins (OR = 4.27, 95% CI 2.33–7.83, P < 0.001), and antipsychotics (OR = 3.33, 95% CI 1.36–8.11, P = 0.006). Higher proportions of use in the BP group vs. control group were found for atorvastatin (OR = 1.86, 95% CI 1.04–3.32, P = 0.035), linagliptin (OR = 6.63, 95% CI 2.17–20.23, P < 0.001), vildagliptin (OR = 3.20, 95% CI 1.73–5.91, P < 0.001), alogliptin (OR = 5.11, 95% CI 1.19–22.04, P = 0.016), and quetiapine (OR = 4.21, 95% CI 1.5–11.85, P = 0.004). The presence of diabetes mellitus in the absence of gliptins did not show any significant effect on BP (OR = 1.60, 95% CI 0.79–3.23, P = 0.188). Metformin intake showed no significant association with BP (OR = 0.48, 95% CI 0.18–1.28, P = 0.143). Our findings confirm and extend previous studies reporting the association of gliptins and antipsychotics on BP in other European populations. The association found for statins is new, thus more studies are needed to corroborate its validity.
Two decades of arthropod biodiversity after windthrow show different dynamics of functional groups
Authors: Wermelinger Beat , Obrist Martin K. , Duelli Peter , Schneider Mathis Doris , Gossner Martin M. 
Published: January 2025

Abstract

Windthrow disturbance is an important driver of arthropod diversity in forests. In the past, studies have mainly focused on the first years after disturbance, and there are hardly any data on arthropod trajectories in windthrows and on salvage logging effects over decades.

We sampled arthropods of different functional groups on 16 permanent plots following two windstorms (Vivian and Lothar) in coniferous and broadleaf forests at different elevations in Central Europe over two decades. Flight interception and pitfall traps were operated during the entire growing seasons in three habitat types per site: unsalvaged windthrow, salvaged windthrow and control forest.

In total, 524,115 individuals from 1666 arthropod species were identified, of which more than 90% occurred in windthrows, including 40%–53% species exclusively found in windthros. Over the two decades, saproxylics, herbivores, pollinators, predators and endangered species showed significantly higher species numbers and abundances in windthrows than in control forests, where only 6% exclusive species occurred.

Arthropod communities in windthrows showed distinct dynamics during the two decades. Their species numbers and abundances peaked in the first 3 years, coined by saproxylic species, such as bark beetles, and by pollinating hoverflies. While abundances declined rapidly, species numbers remained elevated for two decades. Arthropod similarity between windthrows and forests (indicating resilience) increased with time but depended on elevation and forest type. After 20 years, it reached an average of 50% in lowland broadleaf forests, but only 30% in high‐elevation spruce forests, indicating lower resilience.

Salvage logging had no significant effect on overall species numbers but altered species composition. More than 10% exclusive species were found in salvaged and up to 20% in unsalvaged windthrows, with the latter supporting more endangered species, particularly towards the second decade.

Synthesis and applications. Our study shows that windthrow causes an initial boost of arthropod diversity. While abundances thereafter rapidly decline, species numbers remain at relatively high levels during at least two decades. Unsalvaged windthrows are an indispensable resource for endangered species, particularly in later wood decay stages.
Restoring Autophagy by Exercise Ameliorates Insulin Resistance Partly via Calcineurin‐Driven TFEB Nuclear Translocation
Authors: Wang Ping , Li Jiaxin , Li Chun Guang , Zhou Xian , Chen Xiaolong , Zhu Minghua , Wang Hongjiang 
Published: January 2025

ABSTRACTExercise activates autophagy and lysosome system in skeletal muscle, which are known to play an important role in metabolic adaptation. However, the mechanism of exercise‐activated autophagy and lysosome system in obese insulin resistance remains covert. In this study, we investigated the role of exercise‐induced activation of autophagy and lysosome system in improving glucose metabolism of skeletal muscle. Male C57BL/6 mice were randomly divided into five groups: the chow diet (CD) group, the high‐fat diet (HFD) group, the high‐fat diet plus exercise (HFD‐E) group and the HFD‐E treated with calcineurin inhibitor FK506 (HFD‐E‐F) or saline (HFD‐E‐S) groups. The mice in exercise groups (HFD‐E, HFD‐E‐F and HFD‐E‐S) were subjected to aerobic treadmill exercise (speed at 12 m/min for 1 h per session, 0° slope, 5 days per week for 12 weeks). Mice of HFD‐E‐F group were intraperitoneally administered FK506 (1 mg/kg), once each day for 2 weeks before the end of exercise. Expressions pTFEB, T‐TFEB and autophagy–lysosome markers, including Beclin1, LC3, ULK1, SQSTM1, LAMP1, CTSD and CTSL proteins in gastrocnemius muscle were analysed. We demonstrated that HFD induced insulin resistance and decreased autophagy‐lysosomal proteins and the exercise significantly increased transcription factor EB (TFEB) translocation from the cytoplasm to the nucleus, restored the impaired autophagy‐lysosomal‐related protein expressions, and improved glucose metabolism. The increase in TFEB nuclear translocation was partly blocked by the calcineurin inhibitor FK506. Our results suggest that exercise promotes autophagy and lysosome restoration by regulating calcineurin‐mediated TFEB nuclear translocation, ultimately alleviating HFD‐induced insulin resistance in mice skeletal muscle.
A peptide from Boletus griseus‐Hypomyces chrysospermus protects against hypertension and associated cardiac and renal damage through modulating RAAS and intestinal microbiota
Authors: Huan Pengtao , Sun Liping , Chen Shupeng , Zhong Yujie , Zhuang Yongliang 
Published: January 2025

AbstractHypertension is a major risk factor for many cardiovascular diseases, which can lead to kidney and heart disease, stroke, and premature death. Inhibiting angiotensin‐converting enzyme (ACE) activity is an effective method to relieve hypertension. Previously, we screened an active peptide KYPHVF (KF6) from Boletus griseus‐Hypomyces chrysospermus with excellent ACE inhibitory activity. This study further evaluated the antihypertensive activity of the KF6 in vivo. KF6 at 10 mg/kg and Captopril (CAP, a positive control) at 10 mg/kg were administrated to spontaneous hypertensive rats (SHRs) for 5 weeks. The results demonstrated that KF6 effectively lowered both diastolic blood pressure (DBP) and systolic blood pressure (SBP), and decreased ACE, AGT, ALD, and ANG II levels in the serum of SHRs. Furthermore, both cardiac and renal injury of SHRs were ameliorated by KF6 through inhibiting fibrosis, inflammation, and oxidative stress. Moreover, KF6 inhibited ACE‐ANG II‐AT1 axis while activating the ACE2‐Ang (1‐7)‐MAS1L pathway, two mutually antagonistic axes of RAAS, in the kidney and heart of SHRs. Additionally, KF6 improved intestinal microbiota composition, mainly by increasing the abundance of Prevotella and Phascolarctobacterium while decreasing the abundance of Alistipes, Clostridium_IV, Nosocomiicoccus, and Allobaculum. Overall, KF6 is a promising ACE inhibitory peptide for lowering blood pressure and mitigating hypertension‐related cardiac and renal damage. The protective effect of KF6 against hypertension is attributed to its ability to modulate RAAS and intestinal microbiota.
Algal lipids: A review on current status and future prospects in food processing
Authors: Ahmad Sameer , Singh Amit , Akram Wasim , Upadhyay Ashutosh , Abrol Ghan Shyam 
Published: January 2025

AbstractThe consumer demand for functional foods derived from natural sources has been enhanced due to health‐promoting effects. Algae are widely available globally as a sustainable source of proteins, lipids, and carbohydrates. Algal lipids are underexplored natural sources that exhibit several nutraceutical effects and applications in fortification, cosmetics, and pharmaceuticals. Both macro‐ and microalgae are composed of high‐quality lipids. These latter involve polar lipids, nonpolar lipids, and essential fatty acids. Therefore, this review aimed to bring out knowledge on the chemistry of various lipids isolated and identified from micro‐ and macroalgae. Further, their extraction using traditional thermal (solid–liquid, and liquid–liquid) and advanced nonthermal (supercritical fluid, microwave‐, ultrasound‐, and enzyme‐assisted) techniques has been explored. Along with this, bioactivities of algal lipids have been discussed. This study explored algal lipids in advancing sustainable food processing technologies that contribute positively to environmental sustainability and global health, in line with United Nations Sustainable Development GroupUnited Nations Sustainable Development Group UNSDGs.
Equipping residential aged care facilities for acute respiratory illness: The Western Sydney experience of improving outbreak management
Authors: Watts Jenny , Jones Christian , Clark Penelope , Lindley Richard I. , Shaban Ramon Z. , Booy Robert , Bag Shopna K. 
Published: January 2025

AbstractObjectivesAcute respiratory illnesses have a disproportionate impact on older people, and especially those living in residential aged care facilities where transmission risks are heightened. Additionally, staff in these facilities have been working under challenging conditions, often ill‐equipped in terms of both training and resources to successfully manage the outbreaks of these illnesses. This paper examines the actions of an Australian public health unit to improve influenza outbreak management in residential aged care facilities and critiques the outcomes through a contemporary lens.MethodsA naturalistic case study using critical thematic analysis was used to study the Western Sydney Public Health Unit's work with the residential aged care facilities under their jurisdiction in the management of influenza outbreaks during 2014–2019.ResultsKey to the Public Health Unit's approach to improving outbreak management in residential aged care facilities was their sustained engagement with aged care stakeholders, activities to build outbreak management capacity in this setting, and an investment in research to inform ongoing action. This engagement was mutually beneficial, as the Public Health Unit and residential aged care facilities became more attuned to each other's needs and challenges. Supporting facility staff in difficult situations resulted in a timelier public health response and improved outbreak management.ConclusionsIn Australia, Public Health Units are important partners in the cumulative development of outbreak management capacity and responsiveness in the residential aged care setting; particularly considering the challenges posed by novel pathogens and in establishing an evidence base for best practice and future preparedness.
A recurrent loss‐of‐function variant in DRC1 causes non‐syndromic severe asthenozoospermia with favorable intracytoplasmic sperm injection and pregnancy outcomes
Authors: Tebbakh Célia , Barbotin Anne‐Laure , Martinez Guillaume , Boursier Angèle , Wehbe Zeina , Hammouda Asma , Thierry‐Mieg Nicolas , Arnoult Christophe , Mustapha Selima Fourati Ben , Zouari Raoudha , Ray Pierre F. , Kherraf Zine‐Eddine 
Published: January 2025

AbstractBackgroundAsthenozoospermia, characterized by reduced sperm motility, is a common cause of male infertility. Multiple morphological abnormalities of the sperm flagella (MMAF) represent a severe and genetically heterogeneous form of asthenozoospermia. Over 50 genes have been associated, but approximately half of MMAF cases remain unexplained. DRC1, a gene involved in the nexin‐dynein regulatory complex (N‐DRC), has been linked to MMAF and primary ciliary dyskinesia (PCD), often with significant variability in clinical presentation.ObjectivesHis study aimed to identify novel pathogenic DRC1 variants in MMAF patients, assess their impact on sperm flagellar structure, and evaluate intracytoplasmic sperm injection (ICSI) and pregnancy outcomes.Materials and methodsA cohort of 196 non‐syndromic MMAF patients was analyzed using whole exome sequencing (WES). Functional validation of candidate variants included immunofluorescence to assess protein expression and transmission electron microscopy (TEM) to identify ultrastructural abnormalities. Assisted reproductive therapy outcomes were also evaluated.ResultsWES identified a recurrent homozygous frameshift variant in DRC1 NM_145038.5: c.109dup; p.(Gln37ProfsTer30) in four patients (2%), all of North African origin, none of whom suffer from PCD‐related symptoms. The variant caused a complete absence of DRC1 protein in spermatozoa. TEM showed flagellar abnormalities, with 10% of axonemal sections revealing peripheral doublet dissociation, suggesting N‐DRC instability. ICSI resulted in a 68.5% fertilization rate, with three out of four couples successfully delivering healthy children.Discussion and conclusionThe identification of a novel and recurrent pathogenic DRC1 variant broadens the mutation spectrum associated with MMAF. The absence of systemic PCD symptoms suggests that DRC1 deficiency may primarily affect spermatogenesis. Notably, the phenotypic spectrum might be influenced by the genetic background, varying across populations. Favorable ICSI outcomes, with a 68.5% fertilization rate and successful pregnancies in three out of four couples, highlight the effectiveness of assisted reproductive techniques for patients with this genetic defect.
From Land Reform to Landfare: Land Claims and the Welfare State in Kerala, India
Authors: Sudheesh R.C. 
Published: January 2025

AbstractWhile large‐scale land reform may still be underway in many countries, other contexts have states responding to land claims through scattered land provision measures. This article puts forward “landfare” as a lens to capture such measures and unpacks its features in one location. The article first explains this term, outlining its location in and departure from the land reform scholarship. It next shows how Kerala, India, widely cited in the scholarship for its 20th century land reform, addresses the land claims of its Adivasi citizens in the 21st century through landfare. Through an exploration of Adivasi land claims and an examination of state responses in Kerala, the article argues that landfare can work through four key modes—obfuscation, withholding available land, projectisation, and welfare fix. Unlike the “land‐to‐the‐tiller” goals of 20th century land reform, 21st century landfare can be aimed at extinguishingland struggles.
Infliximab‐induced symmetrical drug‐related intertriginous and flexural exanthema (SDRIFE) in a patient with ulcerative colitis
Authors: Mokos Mislav , Bulat Vedrana , Likić Robert , Bosnić Filip , Gašparov Slavko 
Published: January 2025

AbstractSymmetrical drug‐related intertriginous and flexural exanthema (SDRIFE) is a rare, symmetrical skin eruption triggered by various medications, predominantly beta‐lactam antibiotics. We report the case of a 69‐year‐old male with moderate‐to‐severe ulcerative colitis who developed SDRIFE following the seventh intravenous administration of infliximab. The patient presented with symmetrical, pruritic erythema in the cubital and popliteal fossae, groins, gluteal and retroauricular regions without systemic involvement. Skin biopsy showed mild exocytosis of T lymphocytes in the epidermis and dense superficial perivascular CD3+ and CD4+ infiltration, consistent with a type IVa hypersensitivity reaction. The patient responded well to a regimen of systemic antihistamines, topical corticosteroids and tacrolimus ointment, with complete regression of lesions within one week. Despite mild recurrences of SDRIFE after each infliximab administration, the therapy was not discontinued due to the mild nature of the reaction and favourable prognosis. The authors are not aware of previously published cases of type IVa SDRIFE induced by infliximab. Unlike previous reports of severe type IVc SDRIFE reactions requiring discontinuation of infliximab, our case highlights the predominance of CD4+ cells, which may explain the mild clinical course. Understanding the underlying immunologic mechanisms of infliximab‐induced SDRIFE could affect treatment decisions and prevent unnecessary discontinuation of effective therapies.
Impact of Social Disadvantage on Medical and Functional Severity in Children With Cerebral Palsy
Authors: Sukal‐Moulton Theresa , Msall Michael E. , Wroblewski Kristen , Safdar Sarah , Gaebler‐Spira Deborah J. 
Published: January 2025

ABSTRACTBackgroundThose with neurological disorders like cerebral palsy (CP) may experience an altered impact of social determinates of health on child functioning and well‐being. We investigated the relationship between relative social advantage and medical and functional outcomes in a large cohort of children, adolescents and young adults with CP (n = 1269, aged 2–84 years).MethodsWe extracted data from the Cerebral Palsy Research Registry and dichotomized a range of independent factors (income, ethnicity and race) into advantaged and disadvantaged/vulnerable and a range of medical and functional outcomes (gross motor, manual ability, behaviour, breathing, nutritional intake, hearing, seizures, language and vision) and computed odds ratios using logistic regression.ResultsWe found significantly more gross and fine motor functional limitations for those with disadvantage in income (p = 0.002 and 0.006), marginalized race (p < 0.001 and 0.062) or ethnicity (p = 0.013 and 0.014). Ethnicity was further implicated in gestational age, whereas minority race played a role in more severe impairments in breathing, nutritional intake, language functioning and low birth weight status.ConclusionWe found evidence of more health and functional challenges for children with CP and social disadvantage in our cohort. Additional access to equitable resources may improve these imbalances and should be prioritized.
An immunohistochemical study of thanatophoric dysplasia type 1 after fetus autopsy examination
Authors: Abba Deka Ioanna , Theotokis Paschalis , Manthou Maria Eleni , Mathioudi Angeliki , Athanasiou Evangelia , Meditskou Soultana 
Published: January 2025

AbstractThe current case report presents the postmortem examination findings of a 17‐week‐old female fetus displaying thanatophoric dysplasia type 1 (TD‐1) due to a known fibroblast growth factor receptor 3 (FGFR3) gene mutation. Gross and X‐ray examination revealed significant abnormalities, including skeletal malformations with prominent TD‐1 femur curvature. Microscopical evaluation indicated inadequate histological growth for the gestational age, with specific organ immaturity noted in multiple hematoxylin and eosin sections from internal organs, bone from epiphyses and diaphyses levels. Immunohistochemical analysis was conducted using specific markers, such as S100, CD34, CD117, glycophorin‐C, and myeloperoxidase, to identify various hematopoietic and mesenchymal cell types. Furthermore, this report underscores the often‐overlooked aspect of fetal hematopoiesis in cases diagnosed with TD‐1, shedding light on the development of hematopoietic cells and their markers in various tissues, with a particular emphasis on the investigation of bone marrow foci in areas with incipient or no apparent ossification. Immunohistochemical identification of hematopoiesis also served as an indirect way to identify areas of incipient or abnormal ossification.