bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic polymorphisms in the C19orf66 gene influenced HIV-1 infection in a Yunnan population
Authors: Zhang Yaxiang , Feng Yue , Liu Yang , Liu Li , Xia Xueshan , Zhang A-Mei 
Published: September 2023

Background
Due to the deficiencies of vaccines and effective medicine, the human immunodeficiency virus (HIV) infection mechanism should be studied. The C19orf66 gene, one of the interferon-stimulated genes (ISGs), expresses broad-spectra anti-viral activity, including inhibiting HIV replication.

Methods
In this study, we collect 421 HIV-1 infected patients and 448 controls to genotype three SNPs in the C19orf66 gene. Then, the association between SNPs and biochemical indices/ HIV-1 subtypes are analyzed.

Results
Genotypes CC and CT of rs12611087 show statistically lower and higher frequencies in HIV-1 infected patients than in controls, respectively. Alleles C and T of rs12611087 play protective and risk roles in Yunnan HIV population, respectively. Biochemical indices analysis shows that HIV-1 infected persons carried genotype TT of rs77076061 express significantly lower CD3+/CD45+ ratio level and higher IBIL level. The epidemic subtypes of HIV-1 patients in this study are CRF 07_BC and CRF 08_BC. Moreover, subtype CRF 08_BC tends to infect persons with genotype CC of rs12611087.

Conclusion
The genetic polymorphisms of the C19orf66 gene are firstly studied and reported to associate with HIV-1 infection and biochemical indices of patients in Yunnan. Furthermore, subtype CRF 08_BC infection could be influenced by genotypes of SNP in the C19orf66 gene.
Factors Affecting the Yield Gap of Brinjal Grown in Jhikargacha Upazila under Jashore District, Bangladesh
Authors: Islam Mohammad Ashraful , Simoon Gazi Hadiuzzaman , Deb Biplob 
Published: September 2023

The purpose of the study was to determine the yield gap of brinjal with the causing factors and explore the relationship between the yield gap and the socioeconomic characteristics of the farmers. The study was conducted with a sample of 50 farmers randomly selected from five villages in Raghunathnagar union under Jhikargacha upazila of Jashore district using a structured interview schedule from February to March 2020. The yield gap was measured based on the differences between the achievable yield recorded at the particular study location and the average actual yield harvested by the farmers. The results revealed that the majority (76.0%) of farmers had a moderate yield gap (26-65.0% gap), while 14.0% had a low yield gap (up to 25.0% gap) and about 10% high yield gap (more than 65% gap). Inadequate amounts of different inputs used in brinjal production along with some socio-psychological-economic characteristics of farmers were the causes of the yield gap. For instance, 80% of farmers had a high gap in the application of Supreme- a locally popular insecticide for controlling fruit and shoot borer, in the case of pesticide application (74% and 76% of farmers had high gap in the application of Amister and Amagold) followed by 74% had high gap in TSP and Mop application, 76% had high gap in Urea application, 60% had high gap in Boron application, 72% had high gap in Gypsum application, almost 58% had medium to high gap in Cowdung application and 44% had high gap in irrigation application. The results of the correlation co-efficient ‘r’ also revealed that family size, farm size, extension contact, farming experience, knowledge, and level of inputs use were negatively significant with yield gap, while the problems they experienced in brinjal production had a positive significant relationship. The top five problems were: price hike of different inputs required for brinjal production, and poor selling price of products as it is maintained by business syndicates along with lack of proper knowledge about fertilizer management, heavy attack of insects and pests in the brinjal fields, insufficient extension services and lack of training of the farmers about the modern production method of brinjal.
Hospital-Diagnosed Infections, Autoimmune Diseases, and Subsequent Dementia Incidence
Authors: Janbek Janet , Laursen Thomas Munk , Frimodt-Møller Niels , Magyari Melinda , Haas Jürgen G. , Lathe Richard , Waldemar Gunhild 
Published: September 2023

ImportanceSystemic inflammation has been suggested to explain reported associations between infections and dementia. Associations between autoimmune diseases and dementia also suggest a role for peripheral systemic inflammation.ObjectiveTo investigate the associations of infections and autoimmune diseases with subsequent dementia incidence and to explore potential shared signals presented by the immune system in the 2 conditions.Design, Setting, and ParticipantsThis nationwide, population-based, registry-based cohort study was conducted between 1978 and 2018 (40-year study period). All Danish residents born 1928 to 1953, alive and in Denmark on January 1, 1978, and at age 65 years were included. Persons with prior registered dementia and those with HIV infections were excluded. Data were analyzed between May 2022 and January 2023.ExposuresHospital-diagnosed infections and autoimmune diseases.Main Outcomes and MeasuresAll-cause dementia, defined as the date of a first registered dementia diagnosis after age 65 years in the registries. Poisson regression with person-years at risk as an offset variable was used to analyze time to first dementia diagnosis.ResultsA total of 1 493 896 individuals (763 987 women [51%]) were followed for 14 093 303 person-years (677 147 [45%] with infections, 127 721 [9%] with autoimmune diseases, and 75 543 [5%] with dementia). Among individuals with infections, 343 504 (51%) were men, whereas among those with autoimmune diseases, 77 466 (61%) were women. The dementia incidence rate ratio (IRR) following any infection was 1.49 (95% CI, 1.47-1.52) and increased along with increasing numbers of infections in a dose-dependent manner. Dementia rates were increased for all infection sites in the short term, but not always in the long term. The dementia IRR following any autoimmune disease was 1.04 (95% CI, 1.01-1.06), but no dose-dependent increase was observed, and only a few autoimmune conditions showed increased IRRs for dementia.Conclusions and RelevanceThese findings may point toward a role for infection-specific processes in the development of dementia, rather than general systemic inflammation, as previously hypothesized. Assessing these 2 conditions in a single setting may allow for additional insights into their roles in dementia and for hypotheses on possible underlying mechanisms.
Industry Payments to United States Rheumatologist‐Authors of Publications in High‐Impact Rheumatology Journals
Authors: Stohl William , Parikh Krishan 
Published: September 2023

ObjectiveA skewed percentage of industry payments goes to “key opinion leaders” (KOLs) whose prominence and influence has increased with time. Given that KOL is neither precisely defined nor quantifiable, we turned to the level of industry payments as a surrogate quantifiable metric and assessed the associations between industry payments to US rheumatologists and their authorships of publications in high‐impact rheumatology journals.MethodsPayments to US rheumatologists during the 2015‐2020 interval were obtained from the Centers for Medicare and Medicaid Services Open Payments database, and authorships were tallied for calendar year 2021 publications in the four rheumatology journals (Lancet Rheumatol, Nat Rev Rheumatol, Ann Rheum Dis, Arthritis Rheumatol) with the highest 2021 journal impact factors and journal citation indicators. Differences between groups were determined by chi‐squared test, unpaired Student's t‐test, one‐way analysis of variance (ANOVA), Mann–Whitney rank sum test, and Kruskal–Wallis one‐way ANOVA on ranks. Correlations were calculated using Spearman rank order. A P value ≤0.05 was considered significant.ResultsThere were 278 individual US rheumatologists who received industry payments and served as authors of publications in the four high‐impact rheumatology journals. Non–research‐associated payments to these individuals strongly correlated with research‐associated payments. Payments to male US rheumatologists were greater than those to their female counterparts, and payments strongly correlated with the number of publications among male authors but only weakly, and often not significantly, among female authors.ConclusionA substantial fraction of the authorships in calendar year 2021 publications in four high‐impact rheumatology journals arose from a very small percentage of all US rheumatologists who had received industry payments during the 2015‐2020 interval. Payments to male US rheumatologist‐authors were strikingly different from those to female US rheumatologist‐authors, and further investigation is needed to explain the glaring difference in payments.
Catalytic Tunable Black Phosphorus/Ceria Nanozyme: A Versatile Oxidation Cycle Accelerator for Alleviating Cisplatin‐Induced Acute Kidney Injury
Authors: Gao Xin , Wang Bei , Li Jingjing , Niu Biao , Cao Lingzhi , Liang Xing‐jie , Zhang Jinchao , Jin Yi , Yang Xinjian 
Published: September 2023

AbstractOxidative stress is one leading inner cause of acute kidney injury (AKI) induced by cisplatin (DDP). Therefore, inhibiting oxidative stress is an important strategy to prevent the occurrence of DDP‐induced AKI. Herein, a pH‐selective “oxidative cycle accelerator” based on black phosphorus/ceria catalytic tunable nanozymes (BP@CeO2‐PEG) to effectively and persistently scavenge ROS for alleviating DDP‐induced AKI is demonstrated. The BP@CeO2‐PEG nanozymes show pH‐dependent multi‐enzymatic activities, which are beneficial for selectively scavenging the excess ROS in renal tissues. In the neutral environment of kidneys, BP@CeO2‐PEG nanozymes can accelerate its catalytic “oxidative cycle” by increasing the ratio of Ce3+/Ce4+ and improving the regeneration of ATP, effectively removing DDP‐induced ROS. In addition, BP@CeO2‐PEG nanozymes can suppress the oxidative stress‐triggered renal tubular epithelial cell apoptosis by inhibiting the PI3K/Akt signaling pathway. However, in the acidic environment of cancers, the presence of H+ inhibits the conversion of Ce4+ to Ce3+, which in turn disrupts the oxidative cycle, resulting in the loss of ROS scavenging ability and ensuring the antitumor effect of DDP. Conclusively, the nanozymes offer an excellent antioxidant for alleviating cisplatin‐induced AKI and extensive use in other ROS‐based injuries.
Efficient Depolymerization of Polyester and Polycarbonate Plastic Waste Catalyzed by Commercially Available Homogeneous and Heterogeneous Manganese Catalysts
Authors: Lourenço Daniel L. , Oliveira Daniela F. , Fernandes Ana C. 
Published: September 2023

AbstractThis work describes the depolymerization of several polyester and polycarbonate plastic waste in value‐added compounds catalyzed by the air stable, cheap and commercially available manganese compounds Mn(OTf)2, Mn2(CO)10, MnBr(CO)5, and MeCpMn(CO)3 using boranes and silanes as the reducing agents with good to excellent yields. Commercial heterogeneous manganese catalyst, manganeses(II) ethyl/butyl phosphonate silica (Si‐Mn), has also proven to be very efficient in the reductive depolymerization of a variety of polyesters and the polycarbonate PC.BPA. The use of Mn(OTf)2, Mn2(CO)10 and Si‐Mn in consecutive depolymerization of polyesters is also investigated, showing that these catalysts remain their excellent activity after several reactions.
Resolving Structure of ssDNA in Solution by Fusing Molecular Simulations and Scattering Experiments with Machine Learning
Authors: Oweida Thomas J. , Yingling Yaroslava G. 
Published: September 2023

AbstractSingle‐stranded DNA (ssDNA) plays a pivotal role in both nanotechnology and various biological processes. Many processes and applications can be better understood with enhanced structural characterization of ssDNA; however, the dynamic nature of the molecule makes accurate characterization with atomistic resolution extremely difficult. This study uses a method that integrates experimental small‐angle X‐ray scatter (SAXS) data and molecular modeling data using a genetic algorithm (GA) to predict an all‐atom conformational ensemble of ssDNA. The results of this study also validate the performance of various AMBER force fields and implicit solvent models for ssDNA. Overall, the results are able to determine the most accurate atomistic representation of poly‐Thymine (polyT) in solution to date that closely matches the experimental SAXS observations enabling a better understanding of the behavior of ssDNA in solution.
Expanding the toolbox for development of metal‐based dual‐functional catalytic membranes
Authors: Kulkarni Mihir , Roy Deepanjali , Khuu Nhan H. , Sanyal Oishi , Ball Madelyn R. 
Published: September 2023

AbstractCatalytic membranes offer opportunities to develop modular, process‐intensified units. Dual‐functional materials, which integrate reactive and separation components in a single material, could play an important role in enabling them. Adapting the various characterization tools that are used to analyze the structures of metal‐based catalysts to these integrated structures could provide vital information for their design and implementation. In this perspective, we highlight the ways in which these tools can be used to analyze nonreactive membranes and non‐integrated systems where the catalyst and the membrane operate as two separate units. A methodology developed to analyze these comparatively simpler systems could be subsequently extended to integrated dual‐functional catalytic membranes. Thus, researchers from the catalysis and membranes communities can work together in a way that will not only lead to fundamental advancements in our understanding of catalytic membranes but also enable their transformation into real, scalable process‐intensified units.
Introduction of hydrogen bond recognition sites in ZIF‐71 for effective separation of bio‐diols in aqueous solutions
Authors: Zhang Jianshuang , Wu Jinglan , Gao Meizhen , Ge Lifang , Wang Mengyao , Dong Jinxiang , Shi Qi 
Published: September 2023

AbstractThe bio‐based diols 1,3‐propanediol (1,3‐PDO) and 2,3‐butanediol (2,3‐BDO) can form strong hydrogen bonds with water, which increases the separation difficulty of diols in aqueous solutions. Herein, a series of mixed‐linker ZIF‐71‐clnImx samples with hydrogen bond–van der Waals (vdW) dual recognition sites have been constructed using 4‐chloro‐5‐nitroimidazole (clnIm) linkers to substitute partially for the original 4,5‐dichloroimidazole (dclIm) linkers of the ZIF‐71 framework. The experimental and calculated results show that ZIF‐71‐clnImx with appropriate clnIm substitution proportion (x = 7.6 and 12.8 mol%) can strengthen the interaction between ZIF‐71‐clnImx and 2,3‐BDO and enhance the adsorption and mass transfer of 2,3‐BDO, thus achieving the efficient separation of 2,3‐BDO/1,3‐PDO. Molecular simulation results further verify that 2,3‐BDO can simultaneously form strong H bonds with the –NO2 of the clnIm linker and weak vdW interactions with the –Cl of the dclIm linker, which are the mixed recognition sites for 2,3‐BDO adsorption intensification in aqueous solution for ZIF‐71‐clnImx.
Janus particle amphiphilicity and capillary interactions at a fluid interface
Authors: Correia Elton L. , Razavi Sepideh 
Published: September 2023

AbstractStudying the behavior of anisotropic particles at fluid interfaces is a rapidly expanding field, as understanding how the introduced anisotropy affects the resulting properties is essential in the engineering of interfacial systems. Surface anisotropic particles, also known as Janus particles (JPs), offer new possibilities for novel applications due to their amphiphilicity and stronger binding to fluid interfaces compared to homogeneous particles. Introducing surface anisotropy creates complexity as the orientation of interfacially bound particles affects interparticle interactions, a contributing factor to the microstructure formation. In this work, we have investigated the microstructure of JP monolayers formed at the air–water interface using particles with different degrees of amphiphilicity and examined the response of the networks to applied compressions. Our findings demonstrate that JPs amphiphilicity is a crucial factor governing their orientation at the interface, which in turn dictates the complexity of the capillary interactions present and the mechanical properties of the ensuing networks.
Monozygotic twins discordant for a congenital cranial dysinnervation disorder with features of Moebius syndrome
Authors: Gates Ryan W. , Webb Bryn D. , Stevenson David A. , Jabs Ethylin Wang , DeFilippo Colette , Ruzhnikov Maura R. Z. , Tise Christina G. 
Published: September 2023

AbstractMoebius syndrome is a congenital cranial dysinnervation disorder (CCDD) that presents with nonprogressive cranial nerve (CN) VI and VII palsies resulting in facial weakness and inability to abduct the eye(s). While many CCDDs have an underlying genetic cause, the etiology of Moebius syndrome remains unclear as most cases are sporadic. Here, we describe a pair of monochorionic, diamniotic twin girls; one with normal growth and development, and one with micrognathia, reduced facial expression, and poor feeding. Magnetic resonance imaging of the brain performed on the affected twin at 19 months of age showed severely hypoplastic or absent CN IV bilaterally, left CN VI smaller than right, and bilateral hypoplastic CN VII and IX, consistent with a diagnosis of a CCDD, most similar to that of Moebius syndrome. Genomic sequencing was performed on each twin and data was assessed for discordant variants, as well as variants in novel and CCDD‐associated genes. No pathogenic, likely pathogenic, or variants of uncertain significance were identified in genes known to be associated with CCDDs or other congenital facial weakness conditions. This family provides further evidence in favor of a stochastic event as the etiology in Moebius syndrome, rather than a monogenic condition.
Photoinduced Cobalt Catalysis for the Reductive Coupling of Pyridines and Dienes Enabled by Paired Single‐Electron Transfer**
Authors: Qin Jingyang , Barday Manuel , Jana Samikshan , Sanosa Nil , Funes‐Ardoiz Ignacio , Teskey Christopher J. 
Published: September 2023

AbstractSelective hydroarylation of dienes has potential to provide swift access to useful building blocks. However, most existing methods rely on dienes stabilised by an aromatic group and transmetallation or nucleophilic attack steps require electron‐rich aryl coupling partners. As such, there are few examples which tolerate wide‐spread heteroarenes such as pyridine. Whilst allylic C−H functionalisation could be considered an alternative approach, the positional selectivity of unsymmetrical substrates is hard to control. Here, we report a general approach for selective hydropyridylation of dienes under mild conditions using metal catalysed hydrogen‐atom transfer. Photoinduced, reductive conditions enable simultaneous formation of a cobalt‐hydride catalyst and the persistent radical of easily‐synthesised pyridyl phosphonium salts. This facilitates selective coupling of dienes in a traceless manner at the C4‐position of a wide‐range of pyridine substrates. The mildness of the method is underscored by its functional‐group tolerance and demonstrated by applications in late‐stage functionalisation. Based on a combination of experimental and computational studies, we propose a mechanistic pathway which proceeds through non‐reversible hydrogen‐atom transfer (HAT) from a cobalt hydride species which is uniquely selective for dienes in the presence of other olefins due to a much higher relative barrier associated with olefin HAT.
Adaptive Catalysts for the Selective Hydrogenation of Bicyclic Heteroaromatics using Ruthenium Nanoparticles on a CO2‐Responsive Support
Authors: Zhang Yuyan , El Sayed Sami , Kang Liqun , Sanger Matthew , Wiegand Thomas , Jessop Philip G. , DeBeer Serena , Bordet Alexis , Leitner Walter 
Published: September 2023

AbstractRuthenium nanoparticles (NPs) immobilized on an amine‐functionalized polymer‐grafted silica support act as adaptive catalysts for the hydrogenation of bicyclic heteroaromatics. Whereas full hydrogenation of benzofuran and quinoline derivatives is achieved under pure H2, introducing CO2 into the H2 gas phase leads to an effective shutdown of the arene hydrogenation while preserving the activity for the hydrogenation of the heteroaromatic part. The selectivity switch originates from the generation of ammonium formate species on the surface of the materials by catalytic hydrogenation of CO2. The CO2 hydrogenation is fully reversible, resulting in a robust and rapid switch between the two states of the catalyst adapting its performance in response to the feed gas composition. A variety of benzofuran and quinoline derivatives were hydrogenated to fully or partially saturated products in high selectivity and yields simply by altering the composition of the feed gas from H2 to H2/CO2. The adaptive catalytic system thus provides controlled access to valuable products using a single catalyst rather than two specific and distinct catalysts with static reactivity.
Reversible Amidation Chemistry Enables Closed‐Loop Chemical Recycling of Carbon Fiber Reinforced Polymer Composites to Monomers and Fibers
Authors: Qin Bo , Liu Siyuan , Xu Jiang‐Fei 
Published: September 2023

AbstractHighly efficient recycling of carbon fiber reinforced polymer composites into monomers and fibers is a formidable challenge. Herein, we present a closed‐loop recycling approach for carbon fiber reinforced polymer composites using reversible amidation chemistry, which enables the complete recovery of intact carbon fibers and pure monomers. The polymer network, synthesized by amidation between a macromonomer linear polyethyleneimine and a bifunctional maleic anhydride cross‐linker, serves as a matrix for the construction of composites with exceptional mechanical properties, thermal stability and solvent resistance. The matrices can be fully depolymerized under the acidic condition at ambient temperature, allowing the effective separation and recovery of both carbon fibers and the two monomers. The reclaimed carbon fibers retain nearly identical mechanical properties to pristine ones, while pure monomers are recycled with high separation yields (>93 %). They can be reused in for multiple cycles for the manufacture of new composites, whose mechanical properties recover over 95 % of their original properties. This line of research presents a promising approach for the design of high‐performance and sustainable thermoset composites, offering significant environmental and economic benefits.