bluuebunny/crossref_metadata_2025_split huggingface dataset:
Petrology of Bengal Fan turbidites (IODP Expeditions 353 and 354): provenance versus diagenetic control
Authors: Limonta Mara , Garzanti Eduardo , Resentini Alberto 
Published: April 2023

ABSTRACT
High-resolution petrographic and heavy-mineral analyses of Bengal Fan turbidites from six cores drilled during IODP Expeditions 353 and 354 elucidate factors controlling their intersample compositional variability as a key to understanding sedimentary processes and erosional evolution of the Himalayan belt since the Miocene. Bengal Fan turbidites are feldspatho-quartzose to litho-feldspatho-quartzose with plagioclase &gt; K-feldspar; slow-settling micas increase in abundance in very fine sand and coarse silt. The feldspar/quartz ratio and higher-rank metamorphic rock fragments notably increase from uppermost Miocene to Pleistocene deposits, which is ascribed to the onset of rapid exhumation of the Eastern Himalayan syntaxis since ∼ 5 Ma. The same trends are documented in Nicobar Fan turbidites, confirming that they belong to the same sedimentary system. Both Bengal and Nicobar fans record a pulse in mass accumulation rate at Tortonian times, when supply of sedimentary and very-low-grade metasedimentary detritus reflected accelerated exhumation of the Lesser Himalaya. In contrast to foreland-basin sediments, where ferromagnesian minerals have been completely dissolved in strata as young as Pliocene–Pleistocene, in both Bengal–Nicobar and Indus fans amphibole invariably represents about half of the moderately rich to rich transparent-heavy-mineral suite, demonstrating that amphibolite-facies Greater Himalaya metamorphic rocks were widely exposed in the Himalayan range well before the late Miocene and possibly since the late Oligocene, as indicated by a few sillimanite and kyanite grains in Bengal Fan sediments as old as 23 Ma and 28 Ma, respectively. Diagenetic dissolution strongly affected olivine and pyroxene in strata older than the middle and early Pleistocene, respectively, whereas amphibole decreases markedly through progressively older Miocene strata. Ferromagnesian minerals and sillimanite are almost completely dissolved in lower Miocene strata, where durable zircon, tourmaline, rutile, and apatite make up half of the strongly depleted heavy-mineral assemblage. Quaternary turbidites from the six studied cores have virtually the same compositional signatures, testifying to efficient homogenization by turbidite transport and reworking across the fan. Turbidites in western cores closer to peninsular India (U1444A and U1454B) are not different from those in eastern cores, indicating very minor supply from the subcontinent. Forward-mixing calculations based on integrated petrographic and heavy-mineral data indicate that sand supply from the Brahmaputra River to Quaternary turbidites was four times larger than supply from the Ganga River, indicating up to six times higher sediment yields and erosion rates in the Brahmaputra than in the Ganga catchment, largely reflecting superfast erosion of the Eastern Himalayan syntaxis.
Host range of strand-biased circularizing integrative elements: a new class of mobile DNA elements nesting in Gammaproteobacteria
Authors: Idola Desmila , Mori Hiroshi , Nagata Yuji , Nonaka Lisa , Yano Hirokazu 
Published: April 2023

Abstract
Background
The strand-biased circularizing integrative elements (SEs) are putatively non-mobilizable integrative elements for transmitting antimicrobial resistance genes. The transposition mode and the prevalence of SEs in prokaryotes remain vague.
Results
To corroborate the transposition mode and the prevalence of SEs, hypothetical transposition intermediates of an SE were searched for in genomic DNA fractions of an SE host. Then, the SE core genes were defined based on gene knockout experiments, and the synteny blocks of their distant homologs were searched for in the RefSeq complete genome sequence database using PSI-BLAST. A genomic DNA fractionation experiment revealed that SE copies are present in a double-stranded nicked circular form in vivo. Operonic structure of three conserved coding sequences (intA, tfp, intB) and srap located at the left end of SEs were identified as essential for attL × attR recombination. The synteny blocks of tfp and srap homologs were detected in 3.6% of the replicons of Gammaproteobacteria but not in other taxa, implying that SE movement is host-dependent. SEs have been discovered most frequently in the orders Vibrionales (19% of replicons), Pseudomonadales (18%), Alteromonadales (17%), and Aeromonadales (12%). Genomic comparisons revealed 35 new SE members with identifiable termini. SEs are present at 1 to 2 copies per replicon and have a median length of 15.7 kb. Three newly identified SE members carry antimicrobial resistance genes, like tmexCD-toprJ, mcr-9, and blaGMA-1. Further experiments validated that three new SE members possess the strand-biased attL × attR recombination activity.
Conclusions
This study suggested that transposition intermediates of SEs are double-stranded circular DNA. The main hosts of SEs are a subset of free-living Gammaproteobacteria; this represents a rather narrow host range compared to those of mobile DNA element groups discovered to date. As the host range, genetic organization, and movements are unique among the mobile DNA elements, SE and its distant relative, GInt, provide a new model system for host-mobile DNA element coevolution studies.
Business sustainability behaviour and alignment with climate targets
Authors: Cenci Simone , Burato Matteo , Rei Marek , Zollo Maurizio 
Published: April 2023

Abstract
Climate actions by the private sector are crucial to cutting global emissions and meeting the climate targets set by the Paris Agreement. In recent years, an increasing number of companies have pledged to help achieve those targets. However, the emissions pathways of most companies are still not aligned with these goals. To explain the root causes of this discrepancy between effort and outcome, we developed a new methodology to track the actions implemented by major public corporations to reduce their emissions. Our analysis shows that, compared to their peers, companies with emissions pathways aligned with climate targets prioritise actions focused on innovation and stakeholder engagement, such as investing in research and development, new products and fostering cooperation with other ecosystem players. Importantly, this differential behaviour can explain companies' alignment with climate goals. Overall, we provide a systematic framework to track companies' efforts to align their emissions with climate targets. Our approach can be used by investors and policymakers to redirect capital towards its most sustainable use and to design behaviourally founded policy interventions to align business emissions with climate targets.
Antimicrobials sales comparison before and after the implementation of nationwide restriction policy in Saudi Arabia
Authors: Alajel Sulaiman , Alzahrani Khaloud O. , Almohaisen Amal , Alrasheed Meshael M. , Almomen Salwa M. 
Published: April 2023

Abstract
Background: Antimicrobials dispensing without a prescription is recognized as a pathway for the emergence of antimicrobial resistance; a serious global public health issue in need of urgent regulatory responses. In mid-2018, the Saudi Ministry of Health initiated a nationwide antimicrobial restriction policy, in which pharmacies are strictlyprohibited from dispensing antimicrobial drugs without physicians’ prescription. Therefore, the objective of this study was to determine if this restriction policy implemented by the Saudi Ministry of Health has led to decrease in antimicrobial drugs sales.
Methods: The annual retail sales information of antimicrobials was obtained from the pharmaceutical database, IQVIA-Multinational Integrated Data Analysis System (IQVIA-MIDAS®) between 2017 and 2019 to compare sales before and after the intervention. Antimicrobial drugs include the following: antibiotics; antifungals; antimycobacterials; combinations and other drugs. Nonparametric Wilcoxon Signed Rank test was used to assess changes in antimicrobials sales from pre- to post- intervention periods.
Results: Our results showed that this intervention policy has achieved significate effects in reducing total antimicrobials sales by 23.2% from 818,916,437 SAR in 2017 to 648,383,630 SAR in 2019. Wilcoxon Signed Rank test showed a statistically significant median decrease in total antimicrobials sales after the intervention with a p-value = 0.0397. Reduction in the antibiotic amoxicillin was responsible for most of the decrease in antimicrobials sales with 70% less in 2019 compared to 2017. On the contrary, continuous increase in sales of some antimicrobial drugs following the restriction policy was observed led by the antibiotic amoxicillin/clavulanic acid.
Conclusion: Our data support the implementation of antimicrobials restriction measures as an effective means of controlling excessive antimicrobials sales and dispensing without prescriptions.
Assessment of Value-Based Healthcare Delivery in Cardiac Care for Children of Amish Families
Authors: Chowdhury Devyani , Ather Mishaal , Snyder Corey , Kodavatiganti Mallika , Eenennaam Fred van , Brigatti Karla , Strauss Kevin 
Published: April 2023

Abstract
Background
Value-based healthcare is a prominent concept that focuses on patient health outcomes to ensure more efficient healthcare. This patient-centered approach can be applied to establish community-specific personalized care. Unique healthcare solutions need to be developed to adapt to the needs of specific populations. This study highlights the comparison of the delivery of care between the Amish and the Non-Amish community in children who have undergone cardiac surgery.
Methods
The results are interpreted to reflect areas of the healthcare delivery that lack value. Pediatric Integrated Care Survey (PICS) was sent to parents/guardians of 160 children who had undergone at least one cardiac surgery, and were followed at Cardiology Care for Children. Majority of the self-pay population consisted of the Amish. The survey consisted of 5 components: access, communication, family impact, goal creation and team functioning. Composite score calculation was done to gauge favorable responses. An independent sample t-test was conducted to assess the differences in patient-centered care, with a 95% confidence interval (p <0.05), between the insured and self-pay patients.
Results
The self-pay community reported fewer medical comorbidities and had a lower utilization of healthcare than those who were insured. Access to care was equally good in both groups. The self-pay group felt that they had better communication and family impact, whereas the insured group felt that the short and long term goals were better defined. The self-pay and the insured groups valued different components, reflecting different perceptions of healthcare.
Conclusion
The study suggests the need for innovations in the delivery of cardiac care for children of Amish families. Value and impact of care should be regularly addressed with both the providers and patients. Clear communication between physicians and patients is critical including establishing short and long-term goals. Decision-making should be equal amongst patients and their families. The role of the patients' families should be regularly addressed. Healthcare utilization, cost, and value should be recognized and addressed. Ultimately, a more efficient healthcare delivery system reduces cost for patients and creates high-value care.
Metamorphic success and production cost of Holothuria scabra reared on microalgal concentrates compared with live microalgae
Authors: Garpa Tomilyn Jan , Caasi Olivier Josh , Juinio-Meñez Marie Antonette 
Published: April 2023

Abstract
Larval food is a bottleneck in the culture of Holothuria scabra. Whether larval metamorphic success and juvenile production can be improved using microalgae concentrates was investigated. Larvae were reared under a fixed daily feeding ration of 20,000 cells mL-1 using three commercial concentrates (Instant Algae®, Reed Mariculture Inc.): TW1200 (Thalassiosira weisflogii; TW), TISO1800 (Isochrysis sp.; TISO), and Shellfish1800 (mixed diatom; SHELL) and compared with live Chaetoceros calcitrans (CC). The diet efficacy was evaluated based on larval development rate, sizes and survival to late auricularia (LA) with hyaline spheres (HS), and post settlement. Larvae in TW did not progress beyond LA. The average size during LA in TISO (855.7 ± 62.67µm) was significantly higher compared with SHELL. Larvae fed CC reached LA stage earlier, attained significantly larger sizes (1028.43 ± 19.38 µm), and have significantly higher incidence and size of HS. Better metamorphic and settlement performance in CC and SHELL may be related to the higher carbohydrate content in these feeds. The average number of post-settled juveniles in CC (9,268 ± 2,183.79) was over three times more than in SHELL, and an order of magnitude for TISO. Because of the low juvenile yield and longer feeding duration, the estimated cost of producing each juvenile using SHELL is PhP 2.00 and PhP 11.77 for TISO, compared to PhP 0.52 using CC. Development of local microalgal concentrates can enable more hatcheries to undertake sandfish culture, and access to more affordable supplemental feed to promote higher post settlement success.
Antipodal Duality between the Higgs and 3-Gluons via of Graviton Regularization
Authors: Maalouf Hani W. 
Published: April 2023

Abstract
The link between the Higgs and 3-gluons is seen provided by a non-Gaussian Regularization for the
Graviton based on indices, such is shown with factors from the Anti-podal Symmetry. That resolves,
their so far abstract connection, via the MHV vertices.
The procedure relied on a small variation of the Lagrangian cosmological term constant,
under a scalable Gauss-Bonnet Gravity. And can resolve, via alternating or even not specific
gravitational expansion coefficients, diagrams convergences containing Gluons and Higgs.
Computing with Speculations
Authors: Tabacchi Marco Elio 
Published: April 2023

Abstract
A novel, alternative approach to the fundamental logic of commonsense reasoning has been recently advanced by Enric Trillas, based on the idea that in order to allow for creativity in automated reasoning, the standard operations of inducing and abducing must be complemented by guessing, or speculating. In this paper, after a recall of Trillas' skeleton formal model, a number of interactive examples that visualize some of the concept involved in Computing with Speculations are presented, followed by a discussion and some proposals on how to overcome some technical hurdles in implementing speculations in a real computational context. Such examples want to be a contribution towards an experimental inquiry, whose concrete implementation ought to be based on the Computational Learning approaches described. The general aim is to introduce, albeit in a prototypical form, a theoretical framework for Natural Reasoning, and the tools to evolve such framework, in combination with other similar endeavours, into a full system of Natural Computing.
Global, Regional, and National Quality of Care Index of Cervical and Ovarian Cancer: A Systematic Analysis for the Global Burden of Disease Study 1990-2019
Authors: Azangou-Khyavy Mohammadreza , Ghasemi Erfan , Rezaei Negar , Khanali Javad , Kolahi Ali-Asghar , Malekpour Mohammad-Reza , Heidari‐Foroozan Mahsa , Nasserinejad Maryam , Mohammadi Esmaeil , Abbasi-Kangevari Mohsen , Ghamari Seyyed-Hadi , Ebrahimi Narges , Koolaji Sogol , Khosravifar Mina , Fateh Sahar Mohammadi , Larijani Bagher , Farzadfar Farshad 
Published: April 2023

Abstract
Background and objective: Cervical cancer is the most preventable and ovarian cancer is the most lethal gynecological cancer. However, in the world, there are disparities in health care performances resulting in differences in the burden of these cancers. The objective of this study was to compare the health-system quality of care and inequities for these cancers using the Quality of Care Index (QCI).
Material and methods: the 1990-2019 data of the Global Burden of Disease (GBD) was analyzed to extract rates of incidence, prevalence, mortality, DALY, YLL, and YLD of cervical and ovarian cancer. Four indices were developed as proxy for the quality of care using abovementioned rates. Thereafter, a Principal Components Analysis (PCA) was applied to construct the Quality of Care Index (QCI) as a summary measure of the developed indices.
Results: The incidence of cervical cancer decreased from 1990 to 2019, whereas the incidence of ovarian cancer increased between these years. However, the mortality rate of both cancers decreased in this interval. The global age-standardized QCI for cervical cancer and ovarian cancer were 43.1 and 48.5 in 1990 and increased to 58.5 and 58.4 in 2019, respectively. QCI for cervical cancer and ovarian cancer generally decreased by aging, and different age groups had inequitable QCIs. Higher income countries generally had higher QCIs for both cancers, but exceptions were also observed.
Conclusions: disparities in the quality of care of cervical and ovarian cancer at various locations, among different SDI levels, and age groups were observed. Acknowledging these disparities highlights the imperative to improve health care systems to reach the aim of equity in the quality of health care for these cancers.
A Novel Strategy for the Detection of Aedes albopictus kdr gene Based on Multiplex PCR-Mass Spectrometry Minisequencing Technology
Authors: mu qunzheng , zhao xin , li fengfeng , li wenyu , zhou xinxin , lun xinchang , wang yiguan , hua dongdong , liu qiyong , xiao di , meng fengxia 
Published: April 2023

Abstract
Objectives
The objective of this study was to construct a novel strategy for the mutation detection of knockdown resistance(kdr)gene in Aedes albopictus using multiplex PCR-mass spectrometry minisequencing technique (mPCR-MS minisequencing).
Methods Based on the single-base mass probe extension of multiplex PCR amplification products in wild and mutant genotype, a matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) method was established to detect 3 mutated sites in Ae. albopictus kdr gene: locus 1016,1532 and 1534.
Results The detection of the three sites can be conducted simultaneously by double PCR amplification combined with MALDI-TOF MS, achieving a detection limit of 20fg/ul. This method is extensible and flexible, and can be used in a high-throughput manner, easily allowing the addition of new mutation sites as needed to identify and track new kdr gene as they emerge.
Conclusions
mPCR-MS minisequencing provides a new option for the detection of kdr gene in Ae. Albopictus.
Using Teaching Interaction Procedure to Increase Empathetic Responding During Cross-racial Behavior Analytic Supervisory Relationships
Authors: Robinson Sapphire U. , Parks Natalie , Lewis Heather L. , Rigdon Charda'e P. 
Published: April 2023

Abstract
As graduate student's racial/ethnic identities continue to diversify among individuals pursuing applied
behavior analysis, there is an increased risk for marginalization to occur during supervision. To promote
successful supervisor-supervisee relationships, supervising behavior analysts need to acquire culturally
responsive practices such as empathetic responding and partake in continuous education to shape their
supervising repertoire. This will expand their ability to provide quality support for supervisees belonging
to various identity groups. The teaching interaction procedure is a training tool that can be used to teach
culturally responsive practices to supervising behavior analysts. It is an evidenced- based tool that has
been used to teach social skills to children and adults. This training tool procedural components consist of
labeling the social skill, providing rationale for that social skill, describing the steps involved in the social
skill, modeling examples and non-examples of the social skill, and providing feedback throughout the
process. The purpose of this study was to evaluate the teaching interaction procedure effectiveness as a
training tool to teach empathetic responding skills to three supervising behavior analysts within crossracial
dyads in a web-based training format. The results of a multiple-baseline design will show the
teaching interaction procedure was effective at training all 3 supervisors empathetic responding in a
contrived setting and suggests this had a positive impact on the perceived level of satisfaction among their
supervisees.
Efficacy of 5-hydroxytryptamine-3 (5-HT3) antagonists adjuvant therapy for moderate to severe obsessive–compulsive disorder: A systematic review and meta-analysis of randomized clinical trials
Authors: Eissazade Negin , Mosavari Hesam , Eghdami Shayan , Boroon Mahsa , Ashrafi Faria , Shalbafan Mohammadreza 
Published: April 2023

Abstract
Background: obsessive–compulsive disorder (OCD) is the fourth most common mental disorder, and selective serotonin reuptake inhibitors (SSRIs) are the cornerstone of its pharmacological treatment. About 40-60% of the cases are treatment-refractory, and this makes searching for second-line treatment necessary. 5-hydroxytryptamine-3 (5-HT3) antagonists are among the many medications that have been used in augmentation with SSRIs.
Objectives: In this systematic review and meta-analysis, we assessed the efficacy of 5-HT3 receptor antagonists in augmentation with SSRIs in treating moderate to severe OCD.
Methods: We searched PubMed, Web of Science, Scopus, Cochrane library, and Google Scholar for relevant trials published up to December 2022. The effect size was the mean difference in Yale-Brown obsessive compulsive scale (Y-BOCS) scores before and after receiving 5-HT3 receptor antagonist drugs in augmentation with SSRIs in moderate to severe OCD patients.
Results: We included 6 randomized-controlled trails (RCTs) with 334 patients assessing the effect of the augmentation of SSRIs with ondansetron, granisetron, and tropisetron on treating moderate to severe OCD. Our results were in favor of the experimental group in total (Z=8.37, P<0.00001), in the compulsion subgroup (Z=5.22, P<0.00001), and in the obsession subgroup (Z=8.33, P<0.00001). They are well-tolerated, and have mild side effects and do not result in withdrawal.
Conclusion: Augmentation of 5HT-3 antagonists with SSRIs can be beneficial in treating moderate to severe OCD. Further multi-center trials under adequate conditions in longer periods are needed to help come up with a comprehensive action plan.