bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of 23 Gbps optical wireless link for 750 km inter-aircraft communications
Authors: Venkata Sudhakar M. , G.K Rajini 
Published: February 2023

Abstract
Optical device research and development is crucial for the implementation of miniaturized wireless optical transmission systems that are capable of transmitting large amounts of data at fast speeds. This work presents the design and evaluation of an optical link for the inter-aircraft interconnects. At the transmitter, the vertically cavity surface emission laser (VCSEL) is used to generate a directly modulated non-return to zero (NRZ) signal. In the receiver, direct detection and Gaussian low-pass filtering are used. The system's performance is evaluated and compared with and without the use of filtration at the detector. BER, sensitivities, and data transmission capability are used to evaluate the performance of optical wireless systems using optisystem software. The range and data rate are enhanced 9-fold and 4-fold, respectively, in comparison to earlier schemes. The results presented show a transmission range of 750 km at a 23 Gbps data rate with a BER of 10-29.
Experimental optimization on mechanical properties of 18Ni-300 maraging steel produced by direct metal laser sintering
Authors: Karlapudy Satish Prakash , Nancharaiah T , Subba Rao V V 
Published: February 2023

Abstract
Maraging steel material characteristics are greatly affected by build orientation and scanning strategies during manufacturing. This research aims to examine the effect of various build orientations and scan strategies on the ultimate strength and microhardness of 18 Ni-300 grade maraging steel. The maraging steel is made using a technology called direct metal laser sintering. Using the Analysis of Variance approach, the effects of processing factors like build orientation, scan techniques, and type of process on ultimate strength, microhardness, and roughness are optimized. The properties tend to be greater in the horizontal orientation when using the XY scan strategy as a result of thermal history variations,. The mechanical performances of maraging steel components in terms of strength values observed were lower in the vertical position compared to all other orientations. The tests are carried out using an L27 orthogonal array and a Taguchi design of experiment. Build orientation XZ, scan method XY, and Solution-aging-aging(SAAT) has the most significant influence on the final ultimate strength, microhardness, and roughness of all the input factors. A2B2C3 is the optimal combination level of control factors. Additionally, a percentage inaccuracy was identified after conducting confirmation tests on the most prominent experimental data.
Strained topological insulator spin field effect transistor
Authors: Bandyopadhyay Supriyo 
Published: February 2023

Abstract
The notion of a spin field effect transistor, where transistor action is realized by manipulating the spin degree of freedom of charge carriers instead of the charge degree of freedom, has captivated researchers for at least three decades. These transistors are typically implemented by modulating the spin orbit interaction in the transistor’s channel with a gate voltage, which causes gate-controlled spin precession of the current carriers, and that modulates the channel current flowing between the ferromagnetic source and drain contacts to implement transistor action. Here, we introduce a new concept for a spin field effect transistor which does not exploit spin-orbit interaction. Its channel is made of the conducting surface of a strained three dimensional topological insulator (3D-TI) thin film and the transistor function is elicited by straining the channel region with a gate voltage (using a piezoelectric under-layer) to modify the energy dispersion relation, or the Dirac velocity, of the TI surface states. This rotates the spins of the carriers in the channel and that modulates the current flowing between the ferromagnetic source and drain contacts to realize transistor action. We call it a strained-topological-insulator-spin-field-effect-transistor, or STI-SPINFET. Its conductance on/off ratio is too poor to make it useful as a switch, but it may have other uses, such as an extremely energy-efficient stand-alone single-transistor frequency multiplier.
Atomically constructing a van der Waals heterostructure of CrTe2/Bi2Te3 by molecular beam epitaxy
Authors: Nie Jin-Hua , Li Rui , Miao Mao-Peng , Fu Ying-Shuang , Zhang Wenhao 
Published: February 2023

Abstract
A 2D heterostructure with proximity coupling of magnetism and topology can provide enthralling prospects for hosting new quantum states and exotic properties that are relevant to next-generation spintronic devices. Here, we synthesize a delicate van der Waals (vdW) heterostructure of CrTe2/Bi2Te3 at the atomic scale via molecular beam epitaxy. Low-temperature scanning tunneling microscopy/spectroscopy measurements are utilized to characterize the geometric and electronic properties of the CrTe2/Bi2Te3 heterostructure with a compressed vdW gap. Detailed structural analysis reveals complex interfacial structures with diversiform step heights and intriguing moiré patterns. The formation of the interface is ascribed to the embedded characteristics of CrTe2 and Bi2Te3 by sharing Te atomic layer upon interfacing, showing intercoupled features of electronic structure for CrTe2 and Bi2Te3. Our study demonstrates a possible approach to construct artificial heterostructures with different types of ordered states, which may be of use for achieving tunable interfacial Dzyaloshinsky–Moriya interactions and tailoring the functional building blocks in low dimensions.
Desire and Asian Diasporic Fiction: Democracy and the Representative Status of Onoto Watanna’sMiss Numè of Japan(1899)
Authors: Yao Xine 
Published: February 2023

Abstract“Onoto Watanna,” the pseudo-Japanese penname of the mixed-race Chinese Winnifred Eaton, acts as a “Bad Grandma” of the Asian North American literary tradition. Building upon Susan Koshy’s and Lisa Lowe’s accounts of the Asian American novel, I approach Watanna’s Miss Numè of Japan (1899) as the “first Asian American novel” representative of an accommodationist, rather than resistant, tendency “Asian American” representation that anticipates the aggregate and disaggregate problems and possibilities of that political formation in US liberal democracy. The novel, a tale of interracial romances set in Japan, tracks the uncomfortable tensions and convergences of desire and Asian diasporic fiction that speaks to the heteronormative bourgeois construction of anti-Black settler colonial “Asian America.” By tapping into the seduction and marriage plot traditions of eighteenth- and nineteenth-century (white) domestic fiction, Miss Numè racially recodes the genre’s processes of meaning-making about freedom, coercion, and material stability onto a comparative global stage. The romances allegorize negotiations between Japan and the US as two rising global imperialist powers, asymmetries of power coded as Asiatic racialized gender. Miss Numè traces fantasies of individualist desire inextricable from the novel’s status as a compromised origin for the Asian American novel and Asian Americanist coalitional politics.With this “bad” early entry in the Asian American literary tradition, the beginnings of a cross-ethnic Asian sensibility reveals the bourgeois fantasies of diasporic desire at its very emergence, not as a postlapsarian ossification.
Serialization, Solipsism, and Swarming: American Politics and the Graphic Novel in the 1970s
Authors: Williams Paul 
Published: February 2023

AbstractRichard Howell’s Glamazon’s Burden, a graphic novel initially serialized between 1977 and 1979, makes a wry allusion to midcentury literary critic Leslie Fiedler in the shape of a book that never existed: Love and Death in the Comic Novel. Prompted by this subtle aside, which implies that the comic or graphic novel might be the vessel for anxious reflection on the state of American democracy, this article explores what the development of long-form comics in the 1970s meant for the articulation of political possibilities. This was the decade when American public commentators—not least President Carter—lamented the narcissism and self-interest of fellow citizens, and many of the era’s graphic novels depict rallies, fundraisers, and election campaigns, emphasizing a political system riddled with corruption and inertia. But if some graphic novels identified a democratic deficit in the American polity, Lee Marrs’s The Further Fattening Adventures of Pudge, Girl Blimp (1973–1978) tacked in a different direction, offering a reinvigorated confidence in the ability to achieve progressive goals through political reform, a hope expressed through expansive formal strategies such as swarming panels.“I am prompted by Howell’s wry suggestion of Love and Death in the Comic Novel to explore what the development of long-form comics meant for the articulation of democratic possibilities and dread in 1970s America.”
Novels of Democratic Exhaustion
Authors: Marcus Sara 
Published: February 2023

AbstractA shared effort to make the US live up to its democratic promises was a regular feature of twentieth-century US fiction. Authors often wrote of the continuation of this endeavor, even in the face of disappointment, as the responsibility of an epic “us”—a national readership that was asked to participate in the ongoing quest. Contrastingly, in many very recent US novels, the collective pursuit of democratic redemption, however uncertain, no longer makes sense as a way to organize a narrative. This essay discusses contemporary novels including Ling Ma’s Severance (2018), Brit Bennett’s The Vanishing Half (2020), Asali Solomon’s The Days of Afrekete (2021), and Vanessa Veselka’s Zazen (2011), books that depict collective attempts to recover US democracy or make it anew as irrelevant or useless, while individual efforts to keep going in the face of crisis portend no brighter future. These narratives map the terrain of our contemporary democratic crisis, a crisis to which it is difficult to envision a solution. Not merely documents of defeat, these books also sharpen our desire for a different future, and they suggest that in seeking to narrate our way out of contemporary crises, we may need to imagine possibilities beyond the bounds of US democracy.Considered together, the books discussed here … map the terrain of our contemporary democratic crisis, a crisis to which it is difficult to envision a solution.
The Plot Against Democracy
Authors: Castronovo Russ 
Published: February 2023

AbstractThe novel often seems sidelined in political commentaries on democracy. In contrast, this essay argues that the novel’s formal capacity for metacommentary supplies an ironic and self-reflexive perspective that can encourage transparency and other values associated with a democratic ethos. Yet while the examples invoked here—Henry Adams’s Democracy: An American Novel (1880) and Joan Didion’s Democracy: A Novel (1984)—reveal this potential, they also illustrate its limit. The essay ends by considering how that limit lies in the novel’s confrontation with the unrepresentable sublime of nuclear war.The novel may thus have no special relation to democracy, and if we acknowledge this point, then the necessity of metacommentary is only a short step away: Why are novels aligned with democracy in the first place?
Post-American Speculations
Authors: Konstantinou Lee 
Published: February 2023

AbstractThis article thinks about the relationship between democracy and the novel through the analysis of two recent science fiction series, Malka Older’s The Centenal Cycle (2016–2018) and Ada Palmer’s Terra Ignota (2016–2021). Both series imagine future planetary democracies in which the US is figured as a conspicuous absence. The Centenal Cycle is set in a future world of planetary “micro-democracy,” in which sovereignty devolves from nation-states to “centenals” consisting of 100,000 people. Terra Ignota, meanwhile, is set in a world dominated by “Hives,” voluntary associations united by hobbies, interests, and values. Both series try to imagine futures in which the US no longer enjoys planetary hegemony, but no other nation-state or regional hegemon has replaced it. They therefore engage in speculations not only about the future of the US but also about possible futures in which the concept of “Westphalian sovereignty” has lost its force and in which capital’s systemic cycles of accumulation, as described by Giovanni Arrighi, no longer operate. In engaging in these speculations, Older and Palmer join recent political conversations that struggle to understand what a “post-American” geopolitical order might look like. Science fiction, this essay argues, offers special formal resources for thinking through such vexed possibilities.
Impact of Emotions on Test of Variables of Attention(TOVA) Performance in a Pediatric Clinical Population: A Retrospective Study
Authors: Barakat Marc , Ezzeddine Reem , Mohsen Heba , Shamseddeen Wael 
Published: February 2023

Abstract

Background
Continuous Performance Tests, like the Test of Variables of Attention (TOVA), are commonly used to assess attention processes in clinical settings. Although a few previous studies have explored the effects of emotions on the outcome of such tests, the results are scarce and contradictory at times.

Objective
Through this retrospective study, we aimed to explore the correlation between performance on the TOVA and parent-reported emotional symptoms in youth.

Methods
We used preexisting datasets of Mood and Feelings Questionnaire, Screen for Child Anxiety Related Disorders, and Vanderbilt Attention-Deficit/Hyperactivity Disorder Diagnostic Rating Scale as well as preexisting results from the TOVA test from 216 patients aged between 8 and 18 years. Pearson’s correlation coefficients, as well as linear regression models, were computed to examine the association between depressive and anxiety symptoms and the four indices of TOVA (response time variability, response time, commission errors, and omission errors). Additionally, we used generalized estimating equations to determine whether the reported emotional symptoms affect the TOVA outcome differently as the test progresses.

Results
Our results showed no significant effect of the reported emotional symptoms on the TOVA results even when controlling for sex or reported inattention and hyperactivity.

Conclusion
TOVA results do not seem to be affected by emotional symptoms in youth. This being said, future studies should also explore other factors that can affect the performance on the TOVA, like motor disability, sleepiness, or neurodevelopmental disorders affecting cognitive abilities.
recountmethylationenables flexible analysis of public blood DNA methylation array data
Authors: Maden Sean K , Walsh Brian , Ellrott Kyle , Hansen Kasper D , Thompson Reid F , Nellore Abhinav 
Published: February 2023

AbstractSummaryThousands of DNA methylation (DNAm) array samples from human blood are publicly available on the Gene Expression Omnibus (GEO), but they remain underutilized for experiment planning, replication and cross-study and cross-platform analyses. To facilitate these tasks, we augmented our recountmethylation R/Bioconductor package with 12 537 uniformly processed EPIC and HM450K blood samples on GEO as well as several new features. We subsequently used our updated package in several illustrative analyses, finding (i) study ID bias adjustment increased variation explained by biological and demographic variables, (ii) most variation in autosomal DNAm was explained by genetic ancestry and CD4+ T-cell fractions and (iii) the dependence of power to detect differential methylation on sample size was similar for each of peripheral blood mononuclear cells (PBMC), whole blood and umbilical cord blood. Finally, we used PBMC and whole blood to perform independent validations, and we recovered 38–46% of differentially methylated probes between sexes from two previously published epigenome-wide association studies.Availability and implementationSource code to reproduce the main results are available on GitHub (repo: recountmethylation_flexible-blood-analysis_manuscript; url: https://github.com/metamaden/recountmethylation_flexible-blood-analysis_manuscript). All data was publicly available and downloaded from the Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo/). Compilations of the analyzed public data can be accessed from the website recount.bio/data (preprocessed HM450K array data: https://recount.bio/data/remethdb_h5se-gm_epic_0-0-2_1589820348/; preprocessed EPIC array data: https://recount.bio/data/remethdb_h5se-gm_epic_0-0-2_1589820348/).Supplementary informationSupplementary data are available at Bioinformatics Advances online.
ComMap: a software to perform large-scale structure-based mapping for cross-linking mass spectrometry
Authors: Zhang Weijie , Shan Yichu , Zhao Lili , Liang Zhen , Liu Chao , Zhang Lihua , Zhang Yukui 
Published: February 2023

AbstractMotivationChemical cross-linking combined with mass spectrometry (CXMS) is now a well-established method for profiling existing protein–protein interactions (PPIs) with partially known structures. It is expected to map the results of CXMS with existing structure databases to study the protein dynamic profile in the structure analysis. However, currently available structure-based analysis software suffers from the difficulty of achieving large-scale analysis. Besides, it is infeasible for structure analysis and data mining on a large scale, since of lacking global measurement of dynamic structure mapping results.ResultsComMap (protein complex structure mapping) is a software designed to perform large-scale structure-based mapping by integrating CXMS data with existing structures. It allows complete the distance calculation of PPIs with existing structures in batch within minutes and provides scores for different PPI-structure pairs of testable hypothetical structural dynamism via a global view.Supplementary informationSupplementary data are available at Bioinformatics online.
Multimodal representation learning for predicting molecule–disease relations
Authors: Wen Jun , Zhang Xiang , Rush Everett , Panickan Vidul A , Li Xingyu , Cai Tianrun , Zhou Doudou , Ho Yuk-Lam , Costa Lauren , Begoli Edmon , Hong Chuan , Gaziano J Michael , Cho Kelly , Lu Junwei , Liao Katherine P , Zitnik Marinka , Cai Tianxi 
Published: February 2023

AbstractMotivationPredicting molecule–disease indications and side effects is important for drug development and pharmacovigilance. Comprehensively mining molecule–molecule, molecule–disease and disease–disease semantic dependencies can potentially improve prediction performance.MethodsWe introduce a Multi-Modal REpresentation Mapping Approach to Predicting molecular-disease relations (M2REMAP) by incorporating clinical semantics learned from electronic health records (EHR) of 12.6 million patients. Specifically, M2REMAP first learns a multimodal molecule representation that synthesizes chemical property and clinical semantic information by mapping molecule chemicals via a deep neural network onto the clinical semantic embedding space shared by drugs, diseases and other common clinical concepts. To infer molecule–disease relations, M2REMAP combines multimodal molecule representation and disease semantic embedding to jointly infer indications and side effects.ResultsWe extensively evaluate M2REMAP on molecule indications, side effects and interactions. Results show that incorporating EHR embeddings improves performance significantly, for example, attaining an improvement over the baseline models by 23.6% in PRC-AUC on indications and 23.9% on side effects. Further, M2REMAP overcomes the limitation of existing methods and effectively predicts drugs for novel diseases and emerging pathogens.Availability and implementationThe code is available at https://github.com/celehs/M2REMAP, and prediction results are provided at https://shiny.parse-health.org/drugs-diseases-dev/.Supplementary informationSupplementary data are available at Bioinformatics online.
Perplexing Presentations: Compulsory Neuronormativity and Cognitive Marginalisation in Social Work Practice with Autistic Mothers of Autistic Children
Authors: Benson Katy Johanna 
Published: February 2023

Abstract
In recent years, there has been growing interest in exploring the experiences of autistic adults through a lens that adopts emancipatory theorisations of autism. However, despite this changing terrain, autistic people remain a highly subjugated population. Research has begun to theorise a distinctive form of epistemic injustice they encounter in which they are denied access to epistemic resources by a society that valorises cognitively normative ways of being, knowing and existing. An under-explored aspect of this emerging literature relates to the experiences of autistic mothers who are, themselves, much more likely to have autistic children. Evidence suggests that they may be at a substantially increased risk of involuntary social work interventions. This study explores the nature of these experiences, drawing on interviews with autistic mothers as well as my own, lived experiences as an autistic mother. It finds that, through a neuro-normative lens of social work scrutiny, indicators of neuro-divergency in both mothers and children are considered perplexing and assigned malign meanings by those with hermeneutic privilege. This was particularly evident in social work responses to children’s difficulties in attending school, with these difficulties located in mothers rather than in exclusionary, hostile school environments.
Dermatological adverse drug reactions to tyrosine kinase inhibitors: a narrative review
Authors: Das Anupam , Sil Abheek , Khan Ismat Ara , Bandyopadhyay Debabrata 
Published: February 2023

Abstract
Tyrosine kinase inhibitors (TKIs) target the signal transduction pathways of protein kinases by several modes of inhibition. Adverse effects are generally dose dependent, with certain side-effects unique to each drug. However, due to similarities in target sites, different classes of TKIs may have identical or overlapping side-effect profiles. This narrative review is an attempt to summarize the common and uncommon adverse effects of different classes of TKIs.
Extracellular distribution of galectin-10 in the esophageal mucosa of patients with eosinophilic esophagitis
Authors: Albinsson Sofie , Lingblom Christine , Johansson Leif , Larsson Helen , Wennerås Christine 
Published: February 2023

Abstract
Eosinophilic esophagitis is a T-cell-driven allergic condition hallmarked by eosinophil infiltration of the esophagus. Eosinophils exposed to proliferating T cells release galectin-10 and have T-cell suppressive function in vitro. The aims of this study were to evaluate if eosinophils co-localize with T cells and release galectin-10 in the esophagus of patients with eosinophilic esophagitis. Esophageal biopsies from 20 patients with eosinophilic esophagitis were stained for major basic protein, galectin-10, CD4, CD8, CD16, and CD81 and analyzed by immunofluorescence confocal microscopy before and after topical corticosteroid treatment. CD4+ T-cell numbers decreased in the esophageal mucosa of responders to treatment but not in the non-responders. Suppressive (CD16+) eosinophils were present in the esophageal mucosa of patients with active disease and decreased after successful treatment. Unexpectedly, eosinophils and T cells were not in direct contact with each other. Instead, the esophageal eosinophils released large amounts of galectin-10-containing extracellular vesicles and featured cytoplasmic projections that contained galectin-10, both of which disappeared from the esophagus of the responders but remained in the non-responders. To conclude, the presence of CD16+ eosinophils together with the massive release of galectin-10-containing extracellular vesicles in the esophageal mucosa might indicate that eosinophils exert T-cell suppression in eosinophilic esophagitis.