bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers prescribing and delirium in the ICU‐A secondary analysis
Authors: Mulkey Malissa A. , Khan Sikandar , Perkins Anthony , Gao Sujuan , Wang Sophia , Campbell Noll , Khan Babar 
Published: March 2023

AbstractBackgroundStudies suggest Angiotensin‐Converting Enzyme inhibitors (ACEI) and Angiotensin Receptor Blockers (ARB) may slow the decline of memory function in individuals with mild to moderate Alzheimer's disease by regulating migroglial activation and oxidative stress within the brain's reticular activating system. Therefore, we evaluated the relationship between delirium prevalence and being prescribed ACEI and ARB in participants admitted to the intensive care units (ICU).MethodsA secondary analysis of data from two parallel pragmatic randomized controlled trials was performed. ACEI and ARB exposure was defined as being prescribed an ACEI or an ARB within six months prior to the ICU admission. The primary endpoint was the first positive delirium assessment based on Confusion Assessment Method for the ICU (CAM‐ICU) for up to thirty days.ResultsA total of 4791 patients admitted to the medical, surgical, and progressive ICU and screened for eligibility for the parent studies between February 2009 and January 2015 from two level 1 trauma and one safety net hospital in a large urban academic health system were included. Delirium rates in the ICU were not significantly different among participants with no exposure to ACEI/ARB (12.6%), or exposure to ACEI (14.4%), ARB (11.8%), or ACEI and ARB in combination (15.4%) in six months prior to the ICU admission. Exposure to ACEI (OR = 0.97[0.77, 1.22]), ARB (OR = 0.70 [0.47, 1.05]), or both (OR = 0.97 [0.33, 2.89]) in six months prior to ICU admission was not significantly associated with odds of delirium during the ICU admission after adjusting for age, gender, race, co‐morbidities, and insurance status.ConclusionsWhile the impact of ACEI and ARB exposure prior to the ICU admission was not associated with the prevalence of delirium in this study, further research is needed to fully understand the impact of antihypertensive medications on delirium.
Estimating microstructural feature distributions from image data using a Bayesian framework
Authors: Wade Noah , Graham‐Brady Lori 
Published: March 2023

AbstractMany microstructural characterizations methods collect data on a regular pixelized grid. This method of discretization introduces a form of measurement error which can be shown to be proportional to the resolution at which they are collected. Intuitively, measurements made from low‐resolution data are associated with higher error, but quantification of this error is typically not performed. This is reflected in international standards for measurements of grain size, which only provide a recommended minimum number of sample points per microstructural component to ensure each component is sufficiently resolved. In this work, a new method for quantifying the relative uncertainty of such pixelized measurements is presented. Using a Bayesian framework and simulated data collection on features collected from a Voronoi tessellation, the distribution of true geometric properties given a particular set of measurements is computed. This conditional feature distribution provides a quantitative estimate for the relative uncertainty associated with measurements made at difference resolutions. The approach is applied to measurements of size, aspect ratio and perimeter of given microstructural components. Size distributions are shown to be the least sensitive to sampling resolution, and evidence is presented which shows that the international standards provide an overly conservative minimum resolution for grain size measurement in microstructures represented by a Voronoi tessellation.
Factors Influencing Contraceptive Choice During the Postpartum Period: A Qualitative Systematic Review
Authors: Robinet Lisa , Jeffredo Alexis , Clesse Christophe 
Published: March 2023

IntroductionThe objective of this article is to identify the factors that influence the choice of contraceptive methods in the postpartum period.MethodsWe conducted a qualitative systematic review including articles published between 2000 and 2021 on postpartum contraception and its related influential factors. Relying on Preferred Reporting Items for Systematic Reviews and Meta‐Analyses and synthesis without meta‐analysis checklists, the search strategy relied on a combination of 2 lists of keywords applied to 9 databases. A bias assessment was carried out with the help of the Cochrane's randomized controlled trial tool, the checklist from Downs and Black, and Consolidated criteria for reporting qualitative research (CoreQ). A thematic analysis was performed to identify categories of influential factors.ResultsA total of 34 studies met our inclusion criteria and enabled us to isolate 4 categories of factors: (1) demographic and economic factors (geographic and ethnic origin, age, living environment, education/wealth), (2) clinical elements (parity, evolution of pregnancy, childbirth and afterwards, contraception used previously and its mechanism, pregnancy planning), (3) health care delivery (pregnancy monitoring, sessions about contraception, health care system, place of delivery), and (4) sociocultural factors (knowledge and beliefs about contraception, religion, the influence of family and society). The decision process related to postpartum contraception is influenced by a combination of socioenvironmental factors and clinical elements.DiscussionThe main influential factors (parity, level of education, knowledge and beliefs about contraception, and influence of family) need to be addressed by clinicians during consultations. Further multivariate research should provide quantitative data on this topic.
Brief versus long maternal separation in lactating rats: Consequences on maternal behavior, emotionality, and brain oxytocin receptor binding
Authors: Demarchi Luisa , Sanson Alice , Bosch Oliver J. 
Published: March 2023

AbstractMaternal separation is a widely used animal model to study early life adversity in offspring. However, only a few studies have focused on the impact of disrupting the maternal bond from the mother's perspective. Such studies reveal alterations in behavior, whereas the underlying neuroendocrine mechanisms remain largely unknown. In this study, we compared the consequences of daily brief maternal separation (BMS; 15 min) versus long maternal separation (LMS; 180 min) during the first week postpartum with respect to behavioral and neuroendocrine changes in lactating Sprague–Dawley dams. Mothers were tested for their maternal care before and after separation, maternal motivation to retrieve pups, as well as anxiety‐related and stress‐coping behaviors. In addition, we analyzed their basal plasma corticosterone levels and oxytocin receptor binding in selected brain regions of the limbic system and maternal network. LMS dams showed higher levels of behavioral alterations compared to BMS and non‐maternally separated (NMS) dams, including increased licking and grooming of the pups and decreased maternal motivation. Anxiety‐related behavior was not affected by either separation paradigm, whereas passive stress‐coping behavior tended to increase in the LMS group. Plasma corticosterone concentrations were not different between groups. Oxytocin receptor binding was higher in the medial preoptic area and tended to be higher in the prelimbic cortex of LMS dams, only. Our results demonstrate that especially daily prolonged maternal separation impacts on the mothers' behavior and oxytocin system, which suggests that enhanced oxytocin receptor binding could be a compensatory mechanism for potentially decreased central oxytocin release due to limited pup contact.
Perinatal blockade of neuronal glutamine transport sex‐differentially alters glutamatergic synaptic transmission and organization of neurons in the ventrolateral ventral media hypothalamus of adult rats
Authors: Liang Shu‐Ling , Liao Wen‐Lin , Chen Rou‐Shayn 
Published: March 2023

AbstractCompared to male pups, perinatal female rats rely heavily on neuronal glutamine (Gln) transport for sustaining glutamatergic synaptic release in neurons of the ventrolateral ventral media nucleus of the hypothalamus (vlVMH). VMH mainly regulates female sexual behavior and increases glutamate release of perinatal hypothalamic neurons, permanently enhances dendrite spine numbers and is associated with brain and behavioral defeminization. We hypothesized that perinatal interruption of neuronal Gln transport may alter the glutamatergic synaptic transmission during adulthood. Perinatal rats of both sexes received an intracerebroventricular injection of a neuronal Gln uptake blocker, alpha‐(methylamino) isobutyric acid (MeAIB, 5 mM), and were raised until adulthood. Whole‐cell voltage‐clamp recordings of miniature excitatory postsynaptic currents (mEPSCs) and evoked EPSCs (eEPSCs) of vlVMH neurons in adult rats with the perinatal pretreatment were conducted and neuron morphology was subjected to post hoc examination. Perinatal MeAIB treatment sex‐differentially increased mEPSC frequency in males, but decreased mEPSC amplitude and synaptic Glu release in females. The pretreatment sex‐differentially decreased eEPSC amplitude in males but increased AMPA/NMDA current ratio in females, and changed the morphology of vlVMH neurons of adult rats to that of the opposite sex. Most alterations in the glutamatergic synaptic transmission resembled the changes occurring during MeAIB acute exposure in perinatal rats of both sexes. We conclude that perinatal blockade of neuronal Gln transport mediates changes via different presynaptic and postsynaptic mechanisms to induce sex‐differential alterations of the glutamatergic synaptic transmission and organization of vlVMH neurons in adult rats. These changes may be permanent and associated with brain and behavior feminization and/or defeminization in rats.
Assessing the relationship between single nucleotide polymorphisms in Wingless signaling pathway genes and sella turcica morphology
Authors: Brancher João Armando , Schuh Rodrigo , Torres Maria Fernanda Pioli , de Melo Teixeira do Brasil Jordanna , Hueb Maria Angélica , dos Santos Haemmerle Carlos Alexandre , Proff Peter , Alam Mohammad Khursheed , Kirschneck Christian , Küchler Erika Calvano 
Published: March 2023

AbstractSella turcica development involves molecular factors and genes responsible for ossification. It is possible that single nucleotide polymorphisms (SNPs) in key genes are involved in morphological variation of sella turcica. Genes belonging to the WNT signaling pathway are involved in the ossification process and are candidates of sella turcica morphology. This study aimed to evaluate if SNPs in WNT6 (rs6754599) and WNT10A (rs10177996 and rs3806557) genes are associated with the calcification and patterns of the sella turcica. Nonsyndromic individuals were included in the research. Cephalometric radiographs were examined and the sella calcification was evaluated and classified according to the calcification of the interclinoid ligament (no calcification, partial calcification, and incomplete calcification) and sella turcica pattern (normal sella turcica, bridge type A—ribbon‐like fusion, bridge type B—extension of the clinoid processes, incomplete bridge, hypertrophic posterior clinoid process, hypotrophic posterior clinoid process, irregularity in the posterior part, pyramidal shape of the dorsum, double contour of the floor, oblique anterior wall, and oblique contour of the floor). DNA samples were used to evaluate SNPs in the WNT genes (rs6754599, rs10177996, and rs3806557) using real‐time PCR. Chi‐square test or Fisher's exact test were used to compare the allele and genotype distributions according to sella turcica phenotypes. The alpha was set as 5% for all comparisons. A total of 169 individuals were included, 133 (78.7%) present sella turcica partially or completely calcified. Sella turcica anomalies were found in 131 individuals (77.5%). Sella turcica bridge type A (27.8%), posterior hypertrophic clinoid process (17.1%), and sella turcica bridge type B (11.2%) were the most prevalent morphological patterns observed. Individuals carrying the TT genotype in rs10177996 (TT vs. CT + CC) had higher chance to present a partially calcified sella turcica (p = 0.047; Odds ratio = 2.27, Confidence Interval 95% 1.01–5.13). In conclusion, the SNP in WNT10A is associated with the calcification phenotype of the sella turcica, the pleiotropic effect of this gene should be taken into consideration in future studies.
Work‐family spillover of satisfaction: The moderating role of domain boundary strength and identity salience
Authors: Provost Savard Yanick , Dagenais‐Desmarais Véronique 
Published: March 2023

AbstractAnswering calls to further explore the role of cognition in the work‐family interface, this study examines the cognitive work‐family spillover of satisfaction. Moreover, to date, theories have proposed identical effects and moderators for the work‐to‐family and the family‐to‐work directions of spillover, an assumption termed the bidirectional parallelism thesis, which we will test. The objective of this study is therefore to examine work‐family boundary strength and domain identity salience as moderators of the spillover of satisfaction from work to family and from family to work. First, while the literature has mostly focused on the positive consequences of boundary strength, we draw on boundary theory to posit that boundary strength of the receiving domain limits satisfaction spillover. Second, in accordance with the enactment effect derived from boundary theory, we argue that spillover originates more strongly from domains that are salient in one's identity. To test these hypotheses, 2637 Canadian workers participated in a two‐wave study. Structural equation modelling analyses showed that job satisfaction had a lagged relationship with family satisfaction irrespective of the levels of home boundary strength and work identity salience. Inversely, family satisfaction had a significant lagged relationship with job satisfaction only when work boundary strength was low or when family identity salience was high. This study contributes to work‐family theories by extending their propositions to satisfaction as a cognitive component of subjective well‐being, as well as testing its spillover in a time frame consistent with the greater stability of cognitive evaluations.
Maxillary and mandibular complete‐arch implant rehabilitation using a complete digital workflow: A case report
Authors: Ahmed Walaa Magdy , Alhazmi Ahlam , Alharbi Mazin Talal , Azhari Amr Ahmed , Alqarni Hatem , Shaheen Hesham F. , Mitwalli Ehab Tawfiq 
Published: March 2023

AbstractThis article summarizes the clinical steps involved in maxillary and mandibular complete‐arch implant rehabilitation using a complete digital workflow. The maxillary arch was recorded using the double digital scan technique, and the mandibular arch using the triple digital scan technique. The digital protocol used in this case report allowed the recording of implant positions via scan bodies, soft tissues, and, most importantly, the interocclusal relationship in the same visit. A new technique for mandibular digital scan was described that uses soft tissue landmarks by creating windows in the patient's provisional prostheses to superimpose the three digital scans and consequently fabricate and verify the maxillary and mandibular prototype prostheses and definitive complete‐arch zirconia prostheses.
Heterogenous associations between Gender‐Sexuality Alliances and LGBTQ adolescents' maladjustment across individual victimization level
Authors: Kaufman T. M. L. , Lessard L. M. , Watson R. J. 
Published: March 2023

AbstractGender‐Sexuality Alliances (GSAs), which are student‐initiated school clubs for LGBTQ youth and allies, can reduce victimization for lesbian, gay, bisexual, transgender, and queer (LGBTQ) youth. This preregistered study identified heterogeneous correlates of GSAs, based on data from an anonymous survey of LGBTQ adolescents aged 13–17 years living in the United States (N = 10,588). In line with the healthy context paradox (Pan et al. [Child Development, 92, 2021, and 1836]), the presence of a GSA exacerbated associations between LGBTQ‐based victimization and depressive symptoms, lower self‐esteem, and lower academic grades—particularly in transgender youth. Inclusive settings, such as GSAs, might prevent increasing disparities by including tailored strategies to monitor and support more vulnerable, victimized LGBTQ youth.
Molecular and morphological characterization of Calonectria quinqueramosa causing leaf blight on Eucalyptus urophylla in Brazil
Authors: Sánchez‐González Enrique Ignacio , Soares Thaissa de Paula Farias , Zarpelon Talyta Galafassi , Zauza Edival Angelo Valverde , Mafia Reginaldo Gonçalves , Ferreira Maria Alves 
Published: March 2023

AbstractOne of the most damaging diseases of Eucalyptus is Calonectria leaf blight, and it causes significant economic losses. In March 2021, symptoms of leaf blight disease were observed in a Eucalyptus commercial plantation in northeastern Brazil. The present study aimed to identify the causal agent based on morphological features, phylogenetic analyses and pathogenicity tests. Based on phylogenetic analyses of the cmdA, his3, tef1 and tub2 gene regions and morphological characteristics, the fungal isolates were identified as Calonectria quinqueramosa, and their pathogenicity to Eucalyptus urophylla was confirmed. The results of this study confirmed the importance of multi‐locus phylogeny supported by morphological characteristics for the proper identification of Calonectria species. To the best of our knowledge, this study highlights the first report of C. quinqueramosa causing leaf blight on E. urophylla trees in northeastern Brazil. This information will be valuable to promote the development of disease management strategies and to lead the development of Eucalyptus genotypes with resistance to Calonectria.
Orchid–mycorrhizal fungi interactions reveal a duality in their network structure in two European regions differing in climate
Authors: Mennicken Sophie , Vogt‐Schilb Hélène , Těšitelová Tamara , Kotilínek Milan , Alomía Yasmin A. , Schatz Bertrand , Jersáková Jana 
Published: March 2023

AbstractNetwork analysis is an effective tool to describe and quantify the ecological interactions between plants and root‐associated fungi. Mycoheterotrophic plants, such as orchids, critically rely on mycorrhizal fungi for nutrients to survive, so investigating the structure of those intimate interactions brings new insights into the plant community assembly and coexistence. So far, there is little consensus on the structure of those interactions, described either as nested (generalist interactions), modular (highly specific interactions) or of both topologies. Biotic factors (e.g., mycorrhizal specificity) were shown to influence the network structure, while there is less evidence of abiotic factor effects. By using next‐generation sequencing of the orchid mycorrhizal fungal (OMF) community associated to with plant individuals belonging to 17 orchid species, we assessed the structure of four orchid–OMF networks in two European regions under contrasting climatic conditions (Mediterranean vs. Continental). Each network contained four to 12 co‐occurring orchid species, including six species shared among the regions. All four networks were both nested and modular, and fungal communities were different between co‐occurring orchid species, despite multiple sharing of fungi across some orchids. Co‐occurring orchid species growing in Mediterranean climate were associated with more dissimilar fungal communities, consistent with a more modular network structure compared to the Continental ones. OMF diversity was comparable among orchid species since most orchids were associated with multiple rarer fungi and with only a few highly dominant ones in the roots. Our results provide useful highlights into potential factors involved in structuring plant–mycorrhizal fungus interactions in different climatic conditions.
Aerial photogrammetry techniques using drones to estimate morphometric measurements and body condition in South American small cetaceans
Authors: de Oliveira Lucas L. , Andriolo Artur , Cremer Marta J. , Zerbini Alexandre N. 
Published: March 2023

AbstractAerial photogrammetry protocols using drones have proved efficient in monitoring free‐living cetaceans. In this work an aerial photogrammetry protocol using a drone was applied to estimate morphometric measurements and body condition variation in two endangered cetacean species, franciscanas (Pontoporia blainvillei, n = 122) and Guiana dolphin (Sotalia guianensis, n = 41). Sampling occurred in winter and summer in Babitonga Bay, southern Brazil. A 115 cm length object was used to calibrate the scale of measurements at different altitudes. A scale calibration model based on eGSD regression by flight altitude was developed (RMSE = 0.039, r2 = 0.9902, ΔAICc = 0.00) and used to convert measurements from pixels to centimeters. Five morphometric measurements (body length ‐ BL, widths at anterior pectoral fin ‐ AP, axilla ‐ AX, anterior dorsal fin ‐ AD, and posterior dorsal fin ‐ PD) were taken from each animal to infer body condition, in which, the widths in the anterior portions of the body as % BL, can be an auxiliary tool in the evaluation of variation in the body condition of the small cetaceans studied. The aerial photogrammetry protocol allowed for estimating morphometric measurements and monitoring seasonal changes in the body condition of the small cetaceans.