bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between maternity care practitioner type and postpartum depression screening
Authors: Bourdeau Althea I. , Harley Kim G. , Nguyen Angela‐Maithy 
Published: July 2023

AbstractBackgroundPostpartum depression (PPD) is increasingly common in the United States and poses a significant threat to maternal and neonatal health. Universal screening for postpartum depression is recommended by numerous organizations, including the American College of Obstetricians and Gynecologists, but is not achieved in practice.MethodsA cross‐sectional, weighted, state‐representative study of California residents who gave birth in 2016 using the Listening to Mothers in California 2018 data set. Primary exposure was type of maternity care professional providing care during pregnancy, and the primary outcome was PPD screening. The secondary exposure was self‐reported depression or anxiety during pregnancy, and the secondary outcome was attending a postpartum office visit. Bivariate analyses were conducted using Rao‐Scott chi‐square tests, and multivariate analyses were conducted using logistic regression.ResultsCompared to participants cared for by obstetricians, participants cared for by midwives had 2.6 times the odds of reporting being screened for PPD after controlling for covariates (95% CI = 1.5, 4.4). Receiving care from any other practitioner type compared with an obstetrician was not associated with a different rate of postpartum depression screening. Reporting depression or anxiety during pregnancy was associated with 0.7 times the odds (95% CI = 0.5, 1.0) of returning for postpartum care after controlling for covariates.ConclusionsBeing cared for by a midwife during pregnancy increases the likelihood of being screened for postpartum depression. In addition, even perfectly implemented universal screening will miss a vulnerable sector of the population that is at high risk for postpartum depression and is less likely to return for postpartum care.
Inhibition of squalene epoxidase linking with PI3K/AKT signaling pathway suppresses endometrial cancer
Authors: Ma Liangjian , Huang Wunan , Liang Xiaolei , Bai Guannan , Wang Xiaochen , Jiang Hua , Xin Yang , Hu Lidan , Chen Xiangjun , Liu Chang 
Published: July 2023

AbstractEndometrial cancer (EC) is a common malignant tumor that lacks any therapeutic target and, in many cases, recurrence is the leading ca use of morbidity and mortality in women. Widely known EC has a strongly positive correlation with abnormal lipid metabolism. Squalene epoxidase (SQLE), a crucial enzyme in the cholesterol synthesis pathway regulating lipid metabolic processes has been found to be associated with various cancers in recent years. Here, we focused on studying the role of SQLE in EC. Our study revealed that SQLE expression level was upregulated significantly in EC tissues. In vitro experiments showed that SQLE overexpression significantly promoted the proliferation, and inhibited cell apoptosis of EC cells, whereas SQLE knockdown or use of terbinafine showed the opposite results. Furthermore, we found out that the promotional effect of SQLE on the proliferation of EC cells might be achieved by activating the PI3K/AKT pathway. In vivo, studies confirmed that the knockdown of SQLE or terbinafine can observably inhibit tumor growth in nude mice. These results indicate that SQLE may promote the progression of EC by activating the PI3K/AKT pathway. Moreover, SQLE is a potential target for EC treatment and its inhibitor, terbinafine, has the potential to become a targeted drug for EC treatment.
Investigating challenges and family resilience among Chinese families with cross‐boundary students: A multisystemic approach
Authors: Bu He , Liu Iris Kam‐fung , Chi Xinli , Yu Nancy Xiaonan 
Published: July 2023

AbstractTargeting families with cross‐boundary students (CBSs, 跨境学童) who travel daily between Mainland China and Hong Kong for schooling, this study aimed to identify (a) the challenges that CBS families experience in their daily lives, especially during and following the 2019–2020 Hong Kong protest, and (b) the key resources and the interactions of these recourses within and across family systems that strengthened family resilience. Data from semi‐structured interviews with 15 parents of CBS were analysed using thematic analysis, following Walsh's family resilience framework and multisystemic resilience views. The results showed that CBS families encountered three sources of challenges: contextual challenges, chronic family challenges and structural challenges. Despite challenges, we found that six types of resources interacted across multiple levels within and outside of the family: collectivist‐minded view of resilience, hope and perseverance, acceptance and strive, emotional regulation of self and others, family harmony and economic and instrumental supports. These resources helped CBS families maintain family functioning, alleviate situational stress and facilitate family transformation. This study produced new knowledge about CBS families. Findings suggest that fostering the resilience of CBS families relies as much on the families themselves as it does on other structural supports.
Staged or simultaneous operations for ventriculoperitoneal shunt and cranioplasty: Evidence from a meta‐analysis
Authors: Zhang Jun , Deng Xinyu , Yuan Qiang , Fu Pengfei , Wang Meihua , Wu Gang , Yang Lei , Yuan Cong , Du Zhuoying , Hu Jin 
Published: July 2023

AbstractObjectiveTo date, there is no consensus on the surgery strategies of cranioplasty (CP) and ventriculoperitoneal shunt (VPS) placement. This meta‐analysis aimed to investigate the safety of staged and simultaneous operation in patients with comorbid cranial defects with hydrocephalus to inform future surgery protocols.MethodsA meta‐analysis of PubMed, Ovid, Web of Science, and Cochrane Library databases from the inception dates to February 8, 2023 adherent to PRISMA guidelines was conducted. The pooled analyses were conducted using RevMan 5.3 software. The outcomes included postoperative infection, reoperation, shunt obstruction, hematoma, and subdural effusion.ResultsOf the 956 studies initially retrieved, 10 articles encompassing 515 patients were included. Among the total patients, 193 (37.48%) and 322 (62.52%), respectively, underwent simultaneous and staged surgeries. The finding of pooled analysis indicated that staged surgery was associated with lower rate of subdural effusion (14% in the simultaneous groups vs. 5.4% in the staged groups; OR = 2.39, 95% CI: 1.04–5.49, p = 0.04). However, there were no significant differences in overall infection (OR = 1.92, 95% CI: 0.74–4.97, p = 0.18), central nervous system infection (OR = 1.50, 95% CI: 0.68–3.31, p = 0.31), cranioplasty infection (OR = 1.58, 95% CI: 0.50–5.00, p = 0.44), shunt infection (OR = 1.30, 95% CI: 0.38–4.52, p = 0.67), reoperation (OR = 1.51, 95% CI: 0.38–6.00, p = 0.55), shunt obstruction (OR = 0.73, 95% CI: 0.25–2.16, p = 0.57), epidural hematoma (OR = 2.20, 95% CI: 0.62–7.86, p = 0.22), subdural hematoma (OR = 1.20, 95% CI: 0.10–14.19, p = 0.88), and intracranial hematoma (OR = 1.31, 95% CI: 0.42–4.07, p = 0.64). Moreover, subgroup analysis failed to yield new insights.ConclusionsStaged surgery is associated with a lower rate of postoperative subdural effusion. However, from the evidence of sensitivity analysis, this result is not stable. Therefore, our conclusion should be viewed with caution, and neurosurgeons in practice should make individualized decisions based on each patient's condition and cerebrospinal fluid tap test.
Comprehensive view of macrophage autophagy and its application in cardiovascular diseases
Authors: Pan Wanqian , Zhang Jun , Zhang Lei , Zhang Yue , Song Yiyi , Han Lianhua , Tan Mingyue , Yin Yunfei , Yang Tianke , Jiang Tingbo , Li Hongxia 
Published: July 2023

AbstractCardiovascular diseases (CVDs) are the primary drivers of the growing public health epidemic and the leading cause of premature mortality and economic burden worldwide. With decades of research, CVDs have been proven to be associated with the dysregulation of the inflammatory response, with macrophages playing imperative roles in influencing the prognosis of CVDs. Autophagy is a conserved pathway that maintains cellular functions. Emerging evidence has revealed an intrinsic connection between autophagy and macrophage functions. This review focuses on the role and underlying mechanisms of autophagy‐mediated regulation of macrophage plasticity in polarization, inflammasome activation, cytokine secretion, metabolism, phagocytosis, and the number of macrophages. In addition, autophagy has been shown to connect macrophages and heart cells. It is attributed to specific substrate degradation or signalling pathway activation by autophagy‐related proteins. Referring to the latest reports, applications targeting macrophage autophagy have been discussed in CVDs, such as atherosclerosis, myocardial infarction, heart failure, and myocarditis. This review describes a novel approach for future CVD therapies.
Major contribution of sulfide‐derived sulfur to the benthic food web in a large freshwater lake
Authors: Onishi Yuji , Yamanaka Toshiro , Koba Keisuke 
Published: July 2023

AbstractIn freshwater systems, contributions of chemosynthetic products by sulfur‐oxidizing bacteria in sediments as nutritional resources in benthic food webs remain unclear, even though chemosynthetic products might be an important nutritional resource for benthic food webs in deep‐sea hydrothermal vents and shallow marine systems. To study geochemical aspects of this trophic pathway, we sampled sediment cores and benthic animals at two sites (90 and 50 m water depths) in the largest freshwater (mesotrophic) lake in Japan: Lake Biwa. Stable carbon, nitrogen, and sulfur isotopes of the sediments and animals were measured to elucidate the sulfur nutritional resources for the benthic food web precisely by calculating the contributions of the incorporation of sulfide‐derived sulfur to the biomass and of the biogeochemical sulfur cycle supporting the sulfur nutritional resource. The recovered sediment cores showed increases in 34S‐depleted sulfide at 5 cm sediment depth and showed low sulfide concentration with high δ34S in deeper layers, suggesting an association of microbial activities with sulfate reduction and sulfide oxidation in the sediments. The sulfur‐oxidizing bacteria may contribute to benthic animal biomass. Calculations based on the biomass, sulfur content, and contribution to sulfide‐derived sulfur of each animal comprising the benthic food web revealed that 58%–67% of the total biomass sulfur in the benthic food web of Lake Biwa is occupied by sulfide‐derived sulfur. Such a large contribution implies that the chemosynthetic products of sulfur‐oxidizing bacteria are important nutritional resources supporting benthic food webs in the lake ecosystems, at least in terms of sulfur. The results present a new trophic pathway for sulfur that has been overlooked in lake ecosystems with low‐sulfate concentrations.
Strategic career building during your PhD: a timeline for maximizing your opportunities
Authors: Liston Adrian , Makaroff Lydia E 
Published: July 2023

AbstractPhD training can be incredibly versatile, leading to many downstream careers. There is potential to gain training to help you enter any of these careers after graduation. However, it is often only in retrospect that the options and optimal strategies become clear. Here we provide a strategic framework to empower PhD researchers to build and expand their career options in a method compatible with tomorrow's career ecosystem. The strategic framework encourages early career researchers to take a self‐directed approach to establish flexible career goals, diversify exposures and build professional networks. Researchers increase their chances of success by building early markers of multiple career pathways into their PhD program. The framework emphasizes self‐direction, adaptability and resilience, enabling early career researchers to embrace new opportunities and to navigate uncertainties. This structured approach empowers PhD researchers to maximize their opportunities, positioning them for long‐term success in the various career options within and beyond academia.
Association between office visit intervals and long‐term cardiovascular risk in hypertensive patients
Authors: Kim Duon , Jeong Hyunmook , Kim Suhyun , Shin Ho‐Gyun , Park Kyun‐Ik , Lee Seung‐Pyo , Lee Hee‐Sun , Lee Ju‐Yeun , Kim Kwang‐il , Kang Si‐Hyuck , Lee Jang Hoon , Jang Se Yong , Lee Ju‐Hee , Kim Kye Hun , Cho Jae Yeong , Park Jae‐Hyeong , Park Sue K. , Kim Seungyeon , Kim Kwangsoo , Lee Hae‐Young 
Published: July 2023

AbstractHypertension is a chronic disease that requires long‐term follow‐up in many patients, however, optimal visit intervals are not well‐established. This study aimed to evaluate the incidences of major cardiovascular events (MACEs) according to visit intervals. We analyzed data from 9894 hypertensive patients in the Korean Hypertension Cohort, which enrolled and followed up 11,043 patients for over 10 years. Participants were classified into five groups based on their median visit intervals (MVIs) during the 4‐year period and MACEs were compared among the groups. The patients were divided into clinically relevant MVIs of one (1013; 10%), two (1299; 13%), three (2732; 28%), four (2355; 24%), and six months (2515; 25%). The median follow‐up period was 5 years (range: 1745 ± 293 days). The longer visit interval groups did not have an increased cumulative incidence of MACE (12.9%, 11.8%, 6.7%, 5.9%, and 4%, respectively). In the Cox proportional hazards model, those in the longer MVI group had a smaller hazard ratio (HR) for MACEs or all‐cause death: 1.77 (95% confidence interval [CI], 1.45–2.17), 1.7 (95% CI: 1.41–2.05), 0.90 (95% CI: 0.74–1.09) and 0.64 (95% CI: 0.52–0.79), respectively (Reference MVI group of 75–104 days). In conclusion, a follow‐up visits with a longer interval of 3–6 months was not associated with an increased risk of MACE or all‐cause death in hypertensive patients. Therefore, once medication adjustment is stabilized, a longer interval of 3–6 months is reasonable, reducing medical expenses without increasing the risk of cardiovascular outcomes.
Female reproductive fluid concentrations affect sperm performance of alternative male phenotypes in an external fertilizer
Authors: Pinzoni Livia , Locatello Lisa , Gasparini Clelia , Rasotto Maria Berica 
Published: July 2023

Abstract
There is growing evidence that the female reproductive fluid (FRF) plays an important role in cryptic female choice through its differential effect on the performance of sperm from different males. In a natural spawning event, the male(s) may release ejaculate closer or further away from the spawning female. If the relative spatial proximity of competing males reflects the female pre-mating preference towards those males, then favoured males will encounter higher concentrations of FRF than unpreferred males. Despite this being a common situation in many external fertilizers, whether different concentrations of FRF can differentially influence the sperm performance of distinct male phenotypes (favoured and unfavoured by the female) remains to be elucidated. Here, we tested this hypothesis using the grass goby (Zosterisessor ophiocephalus), a fish with distinct territorial-sneaker reproductive tactics and female pre-mating preference towards territorial males, that consequently mate in an advantaged position and whose sperm experience higher concentrations of FRF. Our findings revealed a differential concentration-dependent effect of FRF over sneaker and territorial sperm motility only at low concentrations (i.e. at the distance where sneakers typically ejaculate), with increasing FRF concentrations (i.e. close to the eggs) similarly boosting the sperm performance of both sneaker and territorial males. The ability to release sperm close to the eggs is a prerogative of territorials, but FRF can likewise advantage the sperm of those sneakers that are able to get closer, allowing flexibility in the direction of female post-mating choice.
Abstract
The female reproductive fluid (FRF) is emerging as a key mediator of cryptic female choice. However, the importance of the specific FRF concentration encountered by the different competing ejaculates has never been evaluated in a sperm competition context. In this study, we investigate the influence of varying FRF concentrations on the sperm performance of alternative male phenotypes in the grass goby (Zosterisessor ophiocephalus), a species with distinct Territorial(T)-Sneaker(S) reproductive tactics that usually mate in different positions, and whose ejaculates consequently experience different FRF concentrations.
The role of interface distance and underlying substrate on the color adjustment potential of single‐shade composites
Authors: de Livi Gabriella Jesus Santos , Santana Tauan Rosa , Bragança Rafaella Mariana Fontes , de Bragança Garcez Rosa Maria Viana , Faria‐e‐Silva André Luis 
Published: July 2023

AbstractObjectiveThis study assessed how the distance from the composite interface and the underlying chromatic substrate affect the color adjustment potential (CAP) of two single‐shade composites.Materials and MethodsCylinder‐shaped specimens were created using Vittra APS Unique (VU), Charisma Diamond One (DO), and a shaded (A3) composite. Some single‐shade specimens were surrounded by the A3 composite, forming dual specimens. Color measurements of simple specimens were taken against a gray background using a spectrophotometer. All specimens were positioned at a 45° angle in a viewing booth under illuminant D65, and images were captured with a DSLR camera against gray or A3 backgrounds. Image colors were measured using image processing software and converted to CIELAB coordinates. Color differences (ΔE00) between the single‐shade composites and the A3 composite were calculated. CAP was determined by comparing data from simple and dual specimens.ResultsNo clinically significant differences were observed between color measurements obtained from images and the spectrophotometer. CAP was higher for DO compared to VU and increased as the distance from the composite interface decreased and when specimens were positioned against an A3 background.ConclusionThe color adjustment potential increased with decreased distance from the composite interface and against a chromatic background.Clinical SignificanceAchieving satisfactory color match in restorations using single‐shade composites is crucial, and selecting an appropriate underlying substrate is essential. The color adjustment gradually decreases from the restoration margins towards its center.
Modeling and comparing the distributions and associations of two co‐occurring catshark species off South Africa
Authors: van der Heever G. M. , Yemane D. , Leslie R. W. , van der Lingen C. D. , Gibbons M. J. 
Published: July 2023

AbstractHolohalaelurus regani and Scyliorhinus capensis are relatively small catsharks, which both occur off the continental shelf around South Africa and are often caught together as by‐catch in demersal trawls. The present study used data collected during annual demersal research surveys conducted between 2009 and 2015 and is a first attempt at modeling the potential intra‐ and interspecific associations, by maturity stage and depth, of H. regani and S. capensis to elucidate species‐specific patterns in their distributions in South African waters. Intraspecifically, both species displayed a wide overlap in distribution between maturity stages, but only H. regani displayed marked changes in distribution with maturity stage, with mature individuals found further eastwards and occupying deeper waters than immature individuals. Interspecifically, the two catsharks displayed an inverse relationship in their distribution, with an increase in the abundance of H. regani and a decrease in the abundance of S. capensis when moving from the south coast to the west coast. Some localized patches of co‐occurrence were, however, evident between species and maturity stages, especially in offshore areas. Overall, our results indicated a stronger co‐occurrence of mature and immature stages within each species and a rather weak co‐occurrence of maturity stages between the two species. The spatial information provided in the present study provides useful information on how sharks with similar morphologies and lifestyles may partition their habitat as a mechanism for potentially reducing competition between them.
Interventions to reduce falls in community‐dwelling adults with intellectual disability: a systematic review
Authors: Lalor A. , Callaway L. , Koritsas S. , Curran‐Bennett A. , Wong R. , Zannier R. , Hill K. 
Published: July 2023

AbstractBackgroundPeople with intellectual disability have a high risk of falls and falls‐related injuries. Although people with intellectual disability are at increased risk of falls, there is a need to better understand the efficacy of interventions that can help reduce falls and address risk factors in this population. This systematic review aimed to evaluate the type, nature and effectiveness of interventions undertaken to reduce falls with community‐dwelling adults with intellectual disability and the quality of this evidence.MethodFour electronic databases were searched: Ovid MEDLINE, PsycINFO, CINAHL Plus and the Cochrane Library. Studies were included if they involved people aged 18 years or over, at least 50% of study participants had intellectual disability, participants were community‐dwelling, and the study evaluated any interventions aiming to reduce falls. Study quality was assessed using the National Institutes of Health study quality assessment tools. Reporting of the review followed Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines.ResultsSeven studies were eligible for review, with a total of 286 participants and mean age of 50.4 years. As only one randomised trial was identified, a narrative synthesis of results was undertaken. Five studies evaluated exercise interventions, one evaluated a falls clinic programme, and one evaluated stretch fabric splinting garments. Methodological quality varied (two studies rated as good, four as fair, and one as poor). Exercise interventions varied in terms of exercise type and dosage, frequency and intensity, and most did not align with recommendations for successful falls prevention exercise interventions reported for older people. While the majority of studies reported reduced falls, they differed in methods of reporting falls, and most did not utilise statistical analyses to evaluate outcomes.ConclusionThis review identified a small number of falls prevention intervention studies for people with intellectual disability. Although several studies reported improvements in fall outcomes, ability to draw conclusions about intervention effectiveness is limited by small sample sizes and few studies. Further large‐scale research is required to implement and evaluate falls prevention interventions specifically for adults with intellectual disability.
The making of a conservation frontier: Nation‐building, green productivism, and environmentalism in Patagonia
Authors: Giminiani Piergiorgio Di , Oakley R. Elliott 
Published: July 2023

AbstractIn Patagonia, emerging concerns over environmental degradation in frontier territories suggest the constitution of a new type of frontier—the conservation frontier—in which nature is an object of consumption rather than extraction. Conservation frontiers are made through disputed forms of spatialization, in which wilderness can be a refuge, a source of capital accumulation, and a new space for political experimentation. Three overlapping yet conflicting processes constitute the conservation frontier: nation‐building, green productivism, and environmentalism. The material and discursive making of a conservation frontier illustrates how environmental conservation both disrupts and extends settler projects of territorialization.