bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amisulpride Augmentation in Schizophrenia Patients with Poor Response to Olanzapine: A 4-week, Randomized, Rater-Blind, Controlled, Pilot Study
Authors: Bahk W.-M. , Woo Y. S. , Park S.-Y. , Yoon B.-H. , Wang S.-M. , Kim M.-D. 
Published: August 2023

IntroductionOlanzapine (OLA) is a common first-prescribed antipsychotic and has shown favorable efficacy in acutely exacerbated patients with schizophrenia. The mixed receptor activity of OLA and its greater affinity for serotonin 5-HT2A rather than dopamine D2 receptors are similar to those of clozapine. Pharmacokinetically, OLA is metabolized mainly by hepatic cytochrome enzyme P450 1A2 (CYP1A2). Because risks of antipsychotic polypharmacy include increased drug-drug interactions, pharmacokinetic considerations are important for selection of antipsychotics to be combined. Due to its pharmacological characteristics, amisulpride (AMI), another atypical antipsychotic with proven efficacy, is a promising adjuvant agent of special interest. AMI is unlikely to interact with other drugs due to the low plasma protein binding and metabolism and does not affect the activity of the CYP system. Furthermore, AMI is highly selective for dopamine D2/D3 receptors; has minimal or no affinity for D1, D4, or D5 receptors. Despite the potential benefits of the combination of OLA and AMI, only a few open-label studies have been conducted, and no randomized clinical trial has been performed to date to examine the efficacy and tolerability of the combination. Hence, the goals of this study were to test the hypothesis that AMI augmentation would improve psychotic symptoms and be well tolerated in schizophrenic patients who showed poor response to OLA monotherapy.ObjectivesThe purpose of this study was to compare the efficacy and tolerability of continued olanzapine (OLA) versus amisulpride (AMI) augmentation in schizophrenic patients with poor response to OLA monotherapy.MethodsThe present 4-week, randomized, rater-blinded study included 25 patients with schizophrenia who were partially or completely unresponsive to treatment with OLA monotherapy. Eligible subjects were randomly assigned at a 1:1 ratio to continuation of OLA monotherapy (OLA group) or OLA with AMI augmentation (AMI group). Efficacy was primarily evaluated using the Positive and Negative Syndrome Scale (PANSS) at baseline and at 1, 2, and 4 weeks.ResultsThe changes in PANSS total score and PANSS-positive subscale score were significantly different (p < 0.05) between the OLA and AMI groups. The differences between the two groups in PANSS-negative subscale, PANSS-general subscale, Brief Psychiatric Rating Scale, and Clinical Global Impression-Severity (CGI-S) scale scores were not statistically significant.ConclusionsAMI augmentation could be an effective strategy for patients with schizophrenia who show inadequate early response to OLA monotherapy.Disclosure of InterestW.-M. Bahk Grant / Research support from: Handok Pharmaceuticals, Seoul, Korea, Y. S. Woo: None Declared, S.-Y. Park: None Declared, B.-H. Yoon: None Declared, S.-M. Wang: None Declared, M.-D. Kim: None Declared
LONGTERM OFF-LABEL USE OF SSRI IN TREATMENT OF EARLY EJACULATION: TWO CASES REPORT
Authors: Becirovic E. , Becirovic A. 
Published: August 2023

IntroductionEarly ejaculation is besides erectile dysfunction the most common exual dysfunction amog males. It can create suffering and inflence relationships. Selective serotonin reuptake inhibitors has known side effect and sometimes are used as treatment for early ejaculation.ObjectivesTo present successful off-label treatment of early ejaculation.MethodsCase report. Two cases.ResultsTwo male patientes with early ejaculation problems that influenced their romatic and sexual life. Older one of them has devorced because of that. Younger has never had romantic or sexual relationship for the same reason. Prescribing SSRI make their love life more productiv. Older one married for the second time and has functional and stabile relationship. Younger one established several romantic and sexualn relatinship and currently is in a stabile romantic relationship.ConclusionsLongterm use of low doses SSRI can be very beneficial in treatment of early ejaculation.Disclosure of InterestNone Declared
Predicting Suicide Attempts among Major Depressive Disorder Patients with Structural Neuroimaging: A Machine Learning Approach
Authors: Fortaner-Uyà L. , Monopoli C. , Calesella F. , Colombo F. , Bravi B. , Maggioni E. , Tassi E. , Poletti S. , Bollettini I. , Benedetti F. , Vai B. 
Published: August 2023

IntroductionEvery year at least one million people die by suicide, with major depressive disorder (MDD) being one of the major causes of suicide deaths. Current suicide risk assessments rely on subjective information, are time consuming, low predictive, and poorly reliable. Thus, finding objective biomarkers of suicidality is crucial to move clinical practice towards a precision psychiatry framework, enhancing suicide risk detection and prevention for MDD.ObjectivesThe present study aimed at applying machine learning (ML) algorithms on both grey matter and white-matter voxel-wise data to discriminate MDD suicide attempters (SA) from non-attempters (nSA).Methods91 currently depressed MDD patients (24 SA, 67 nSA) underwent a structural MRI session. T1-weighted images and diffusion tensor imaging scans were respectively pre-processed using Computational Atlas Toolbox 12 (CAT12) and spatial tract-based statistics (TBSS) on FSL, to obtain both voxel-based morphometry (VBM) and fractional anisotropy (FA) measures. Three classification models were built, entering whole-brain VBM and FA maps alone into a Support Vector Machine (SVM) and combining both modalities into a Multiple Kernel Learning (MKL) algorithm. All models were trained through a 5-fold nested cross-validation with subsampling to calculate reliable estimates of balanced accuracy, specificity, sensitivity, and area under the receiver operator curve (AUC).ResultsModels’ performances are summarized in Table 1.Table 1.Models’ performances.Input featuresAlgorithmSpecificitySensitivityBalanced accuracyAUCVBMSVM55.00%50.00%52.50%0.55FASVM72.00%54.00%63.00%0.62VBM and FAMKL68.00%54.00%61.00%0.58Abbreviations: AUC, area under the receiver operator curve; FA, fractional anisotropy; VBM, voxel-based morphometry.ConclusionsOverall, although overcoming the random classification accuracy (i.e., 50%), performances of all models classifying SA and nSA MDD patients were moderate, possibly due to the imbalanced numerosity of classes, with SVM on FA reaching the highest accuracy. Thus, future studies may enlarge the sample and add different features (e.g., functional neuroimaging data) to develop an objective and reliable predictive model to assess and hence prevent suicide risk among MDD patients.Disclosure of InterestNone Declared
Particular suicides and psychiatric pathologies: Case Series.
Authors: Ritorto V. , Sacco M. A. , Gualtieri S. , Ricci P. , Tarallo A. P. , Aquila I. 
Published: August 2023

IntroductionSuicide is one of the main cause of death in the world. It’s an important public health problem that is growning on new generations.ObjectivesThe manners used to die have always been studied from psychiatry to understand which mental illness induced victim to various ways of suicide. They are multiples and are influenced by different factors. This study includes suicides cases defined “atypical”.MethodsThe cases were examined at the Insitute of legal Medicine Institute of Magna Graecia University of Catanzaro. Methods used were autopsies, and psycological autopsies. The study of the three cases also included the first level toxicological tests..ResultsIn the first case, the victim died for cut injuries by using a kitchen knife on the lateral-cervical region of neck; the inspection revealed superficial lesions (test cuts) which, with progressive depth, reached the vascular-nervous bundle. In the second case, in a family contest of apparent welfare, the victim decided to go out home in the middle of the night, to reach an isolated place: there, when he still was in his car, he spilled on his head flammable liquid to accelerate fire effects.In the case number 3, the victim was found at the bottom of a cliff with earplugs; maybe she was hearing voices in her mind that induced her to death. At home, police found a message on paper about her autopsy will.ConclusionsThe autopsy findings on the cases described are atypical. In every three cases of atypical suicide, the victim was not being treated with therapy, and all victims, probably, were very able to hide their socio-relational malaise. Forensic investigations for the study of suicides must not be limited to the study of fatal injuries. Forensic study about the modalities used to commit suicide wants to be a help to improve knowledge on certain psychiatric pathologies at high risk of suicide.Disclosure of InterestNone Declared
Growing together: Longitudinal trajectory of posttraumatic growth among suicide-loss survivors and its interpersonal predictors
Authors: Levi-Belz Y. 
Published: August 2023

Introduction: BackgroundRecent studies have indicated that grieving after suicide loss can be particularly complex and traumatic. However, studies have recognized the opportunity for personal growth among suicide-loss survivors.ObjectivesThis study signifies an effort to develop a comprehensive understanding of the underlying interpersonal facilitators of posttraumatic growth (PTG) among suicide-loss survivors in a longitudinal design.MethodsParticipants included 189 suicide-loss survivors (155 females), aged 21–73, who completed questionnaires of thwarted belongingness (TB), perceived burdensomeness (PB), and self-disclosure at T1. Moreover, participants were assessed on PTG levels at T1, 18 months (T2), and 42 months (T3).ResultsThe integrated mediation model indicated that both TB and PB contributed to the PTG trajectory. PB and self-disclosure contributed to PTG at T3 beyond the PTG trajectory across time. We also found self-disclosure to mediate the association of TB and PTG at T2 and T3.ConclusionsThese findings suggest that interpersonal factors play critical roles in contributing to PTG over time among suicide-loss survivors. Basic psychoeducational interventions designed to foster interpersonal behaviors may facilitate achieving PTG among survivors in the aftermath of suicide loss.Disclosure of InterestY. Levi-Belz Shareolder of: no, Grant / Research support from: no, Consultant of: no, Employee of: no, Paid Instructor of: no, Speakers bureau of: no
Moral injury and suicide ideation among combat veterans: The moderating role of self-disclosure
Authors: Levi-Belz Y. 
Published: August 2023

IntroductionModern warfare in a civilian setting may expose combatants to severe moral challenges. Whereas most of these challenges are handled effectively, some potentially morally injurious events (PMIEs) may have deleterious psychological effects on the combatants, such as suicide ideation (SI). Self-disclosure, which includes sharing distressing thoughts and emotions, has been recognized as a protective factor against SI in the aftermath of stressful events.ObjectivesThe current study is the first to examine the moderating role of self-disclosure in the relationship between PMIEs exposure and SI among combat veterans.MethodsA sample of 190 recently discharged Israeli combat veterans completed validated self-report questionnaires in a cross-sectional design study, tapping combat exposure, PMIEs, depressive symptoms, SI, and self-disclosure.ResultsPMIE dimensions, and self-disclosure significantly contributed to current SI. Importantly, the moderating model indicated that self-disclosure moderated the link between PMIE-Self and current SI , as PMIE-Self and current SI were more strongly associated among veterans with low levels of self-disclosure than among high self-disclosing veterans.ConclusionsSelf-disclosure, as a factor promoting a sense of belongingness, interpersonal bonding, and support, might reduce SI risk following PMIE exposure. Various mechanisms accounting for these associations are suggested, and clinical implications of these interactions are discussed.Disclosure of InterestY. Levi-Belz Shareolder of: no, Grant / Research support from: no, Consultant of: no, Employee of: no, Paid Instructor of: no, Speakers bureau of: no
Relevance of Group Training for Psychiatrists: an Experiential-Strategic model.
Authors: Battuello M. , Flore A. , Mele T. I. , Zagaria C. L. 
Published: August 2023

IntroductionThere are many stressors that lead to burn out and decrease the quality of life of health professionals as a whole and it occurs also to trainee psychiatrists.Training programs rarely include specific interest in the personal self of students even if they begin to deal with severe human suffering.Authors present a model of experiential group training in psychiatry that is centred on the person/trainee at the very most.ObjectivesThe aim is to focus on unsolved emotional needs of students to allow them to achieve the capacity of relationship with patients. It is not a mere application of empathy but a truth overcoming, for trainees, of major risks of collusion due to reflection of individual conflicts into the patients and/or due to the encounter with strong emotion during clinical training.MethodsThe model is Experiential because it is the space for personal expression and it is Strategic because it is born inside the strategic group training in psychotherapy (Battuello et al. Psichiatria e Psicoterapia 2022; 41, 2, 65-82).The conductor of the group carries on her/his skin the experience of own training group, to be brought into the trainees’ one.This is an original approach because the epistemology of the model came directly from the experience.The group is led by a psychotherapist that plays an active part inside the process instead of being only a facilitator.The main focus is to allow students to express themselves that includes various steps such as: tuning with their own experiences/emotions, freedom of expressing them to the group, active listening to the other and response to the same other even when feelings don’t resonate but instead are divergent.This phase is related to the conductor’s participation that is totally immersed into the group bringing personal feelings, stories and emotions to create an undifferentiated space, free from hierarchical roles.During a second period, students can access a more mature relational capacity that carries the group to a phase of individuation of the self that also engages professional issues.ResultsStudents in the group question themselves: it is the root of every health professional that has to explore and overcome personal relational issues. Only after the expressiveness phase, as authors name this part of the training, an individuation phase is truly possible that leads to the definition of the professional.ConclusionsThe training group is necessary for students to explore the wider range of emotions, expressing personal ones, accepting others’, experiencing the tolerance to their frustration, and emerging as professional, that is, in few words, professional of the relationship, the key and the basement of the psychiatrist.The training in mental health should include, at first, the taking care of the person/student as it is proposed by authors inside the group model.Disclosure of InterestNone Declared
Affective and physiological responses to human body odors in social anxiety – a pilot study on the possible effects as catalyst for treatment
Authors: Vigna E. , Cecchetto C. , Dal Bò E. , Hadlaczky G. , Wasserman D. , Carli V. 
Published: August 2023

IntroductionUnderstanding the way chemistry influences human communication is important since the reaction to chemosignals has many implications for science and society.Numerous research points out that human beings are able to identify feelings of fear and happiness through smell. Such emotional information can lead to approach-avoidance behaviors or changes in affective state. Moreover, a heightened sensitivity to social odors has been shown in subjects with social anxiety symptoms. However, more detailed research on the connection between olfaction, affective psychiatric disorders and interpersonal social communication is required.POTION is an EU funded project within the Horizon2020 initiative that aims at understanding the nature of chemosignals in humans and their sphere of influence on social interaction. Whitin this project, we conducted a preliminary study showing that individuals with social anxiety symptoms benefited from mindfulness training especially when exposed to social chemosignals. A significant reduction in anxiety symptoms was achieved with both the happiness (t(25)=4.37, p=0.029) and the fear (t(25)=4.35, p=0.031) chemosignals. Moreover, individuals exposed to the happiness chemosignal exhibit highier vagal tone compared to subjects exposed to fear chemosignals (p = 0.026), indicating overall increased well-being.ObjectivesGiven the exploratory nature of the preliminary study, an hypothesis driven pilot-RCT with larger sample size and refined design has been conducted. The aim was to further explore the catalyst effect of body odor on anxiety reduction. Notably, if the odor groups (happiness, fear or neutral) differ with the control group (clean air) and if they differ between each other in the outcome measure.MethodsTo this end, 96 participants with social anxiety symptoms (women aged between 18 to 35) were randomly allocated to one exposure group (happiness, fear or neutral human body odor or clean air) and followed a mindfulness intervention while being exposed to the odor. Psychological outcomes were measured before and after the intervention through the State-Trait Anxiety Inventory. During the intervention participants’ skin conductance and heart rate was also measured.Analysis of variance will be performed to assess psychological outcome differences between and within groups, as well as interactions (GroupxTime).ResultsResults of the study will be available and presented at the time of the congress.ConclusionsThis study represents an advancement in the field mental health as it explores the potential impact of using human chemosignals in the clinical setting.Disclosure of InterestNone Declared
Self esteem among Tunisian women victims of domestic violence
Authors: Jbir R. , Aribi L. , Chaari I. , Mseddi N. , Halouani N. , Aloulou J. 
Published: August 2023

IntroductionIntimate partner violence is an under recognized problem in our society that is misjudged and often overlooked.Violence in women has been linked to chronic health, emotional complications, one of which includes low self-esteemObjectivesTo study the prevalence and predictors of low self-esteem among women victims of domestic violence.MethodsOur study was descriptive and analytical cross-sectional, carried out with women examined in the context of medical expertise, from May until January 2022.An anonymous survey was asked to these ladies.The Rosenberg questionnaire was used to assess the self esteemResults122 responses was collected.The average age of the assaulted women in our study was 35.66 years(from18 to 64 years) 98.4%were victims of verbal violence, 95,1% of physical violence, 97,5% of psychological violence and 54.7 %of sexual violence.Self esteem was very low among 43,4% of women ,low among 18,9%,average among 15,6%,high among 15,6% and very high among 6,6%.Women with children had lower self-esteem (p=0.02).Low self-esteem were significantly correlated with: the husband cannabis consumption (p=0.01).The ladies victims of sexual violence such as an unusual type of relationship had lower self-esteem (p=0.01).Women who were threatened by their spouses had lower self-esteem (0,01).An history of aggression during pregnancy was a risk factor for low self-esteem (p=0, 01).ConclusionsResults suggest domestic violence has on women, not only physically effect but mentally and emotionally, this is why an urgent reaction must be taken by the state to reduce this scourge and hs repercussions on the mental health of the victims.Disclosure of InterestNone Declared
Associations between polygenic loading, psychosis liability, and clozapine use
Authors: Luykx J. 
Published: August 2023

Introduction
Predictors consistently associated with psychosis liability and course of illness in
schizophrenia (SCZ) spectrum disorders (SSD), including the need for clozapine treatment, are
lacking. Longitudinally ascertained medication use may empower studies examining associations
between polygenic risk scores (PRSs) and pharmacotherapy choices.

Objectives
To examine associations between PRS-SCZ loading and groups with different liabilities
to SSD: individuals with SSD on clozapine, individuals with SSD on other antipsychotics,
their parents and siblings, and unrelated healthy controls; and between PRS-SCZ and the
likelihood of receiving a prescription of clozapine relative to other
antipsychotics.

Methods: Design
Six-year follow-up and cross-sectional observational cohort study.

Setting
Multi-center.

Participants
Individuals diagnosed with SSD using clozapine or other antipsychotics, their parents
and siblings, and unrelated healthy controls.

Exposure
PRS-SCZ.

Main Outcomes and Measures
We used multinomial logistic regression to examine possible differences between groups
by computing risk ratios (RRs), i.e., ratios of the probability of pertaining to a particular
group divided by the probability of healthy control status. We also computed PRS-informed odd
ratios (ORs) for clozapine use relative to other antipsychotics.

Results
PRSs-SCZ were generated for 2344 participants (mean age: 36.95 years; 42.4% female)
remaining after quality control (557 individuals with SSD on clozapine, 350 individuals with
SSD on other antipsychotics during six-year follow-up, 542 parents and 574 siblings of
individuals with SSD, and 321 unrelated healthy controls). All RRs were significantly
different from 1; RRs were highest for individuals with SSD on clozapine (RR=3.24 [95%CI
2.76-3.81], p=2.47x10-46), followed by individuals with SSD on other
antipsychotics (RR=2.30 [95%CI 1.95-2.72], p=3.77x10-22), parents
(RR=1.44 [95%CI 1.25-1.68], p=1.76x10-6), and siblings (RR=1.40 [95%CI
1.21-1.63], p=8.22x10-6). PRS-SCZ was positively associated with
clozapine versus other antipsychotic use (OR=1.41 [95%CI 1.22-1.63],
p=2.98x10-6), suggesting a higher likelihood of clozapine prescriptions
in individuals with higher PRS-SCZ.

Conclusions
PRS-SCZ loading differs between groups of individuals with SSD, their relatives, and
unrelated healthy controls, with clozapine users being at the far end of PRS-SCZ loading.
Additionally, PRS-SCZ is associated with a higher likelihood of clozapine prescribing. Our
findings may inform early intervention and prognostic studies into the value of PRS-SCZ for
personalized antipsychotic treatment.

Disclosure of Interest
None Declared