bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Bergmeister papilla on disc parameters in spectral domain optical coherence tomography
Authors: Chun Yeoun Sook , Moon Nam Ju , Kim Ungsoo Samuel , Yeo Joon Hyung , Jeong Jae Hoon 
Published: January 2023

Abstract
Background: To demonstrate the morphological characteristics of Bergmeister papilla (BMP), a persistent hyaloid remnant tissue, and its effects on the measurements and repeatability of spectral domain optical coherence tomography (OCT).
Methods: A prospective cross-sectional study was used to collect 83 patients with BMP and 76 age-matched unaffected individuals from a tertiary care institution. Imaging including 5-line raster and 3 consecutive optic disc cube scans centered on the optic disc were acquired using the Cirrus HD-OCT. Structural characteristics of BMP were classified according to the images of raster scans, and the repeatability of optic nerve head and retinal nerve fiber layer parameters was analyzed by calculating the test-retest standard deviation, coefficient of variance, and intraclass correlation coefficient.
Results: BMP was categorized into lifting edge (LE) type where does not cover the entire optic nerve head, but partially covers the corners, and covering disc (CD) type in which covers the entire cupping area like a cap. Among the BMP of 83 eyes, 58 (63.9%) were lifting edge type and 33 (36.1%) were CD type, and some of the optic nerve head parameters in OCT showed significant differences between the CD and LE types and normal control eyes. The analysis of repeatability showed that eyes with LE types affected cup volume and nasal retinal nerve fiber layer parameters and correlated with BMP location.
Conclusion: Because BMP might be a pitfall in OCT imaging, it is necessary to be careful when interpreting OCT in an eye with BMP.
Quantifying the uncertainty in future runoff projection over SSP scenarios, GCMs and hydrological model parameters
Authors: Kim Jin Hyuck , Chung Eun Sung , Song Jae Yeol , Shahid Shamsuddin 
Published: January 2023

Abstract

This study evaluated the inherent uncertainty of future runoff prediction using eleven Coupled Model Intercomparison Project 6 (CMIP6) global climate models (GCMs) and a hydrological model (HM). The soil and water assessment tool (SWAT) model was used as a hydrologic model, and SWAT-CUP was used for parameter calibration. The future runoff projection was simulated utilizing two shared socioeconomic pathways (SSPs) scenarios, SSP2-4.5 and SSP5-8.5, for near (2021–2060) and far (2061–2100) futures. Jensen-Shannon divergence (JS-D) was used to quantify the uncertainties between the past and future probability distributions considering different GCMs and calibrated parameter sets of HM. The JS-D value for each GCM and calibrated HM parameter set was calculated at the range of 0.026–0.075 and 0.035–0.058, respectively. As a result, the uncertainty in the selection of GCMs was found to be greater than in the determination of values for HM parameters. Bayesian model averaging (BMA), which is a statistical approach that can combine estimations from multiple models and produce reliable probabilistic predictions, was applied to quantify the uncertainty by each GCM and HM parameters. When estimating the future runoff, INM-CM4-8 caused the greatest uncertainty, and the calibrated set of HM parameters using the year of high runoff caused the greatest uncertainty. This approach can help the uncertainty analysis in the future runoff estimation.
Impact of hormone replacement therapy on all-cause and cancer-specific mortality in colorectal cancer: A systematic review and dose‒response meta-analysis of observational studies
Authors: Liu Kefeng , He Yazhou , Zhang Xianzhuo , Yang Yongjie , Sun Shusen , Mei Zubing , Zhao Jie 
Published: January 2023

Abstract

Background
The effect of hormone replacement therapy (HRT) on colorectal cancer (CRC) mortality and all-cause mortality remains unclear. We conducted a systematic review and dose‒response meta-analysis to determine the effects of HRT on CRC mortality and all-cause mortality.
Methods
We searched the PubMed, Embase, and Cochrane Library electronic databases for all relevant studies published until June 2022 to investigate the effects of HRT exposure on survival rates for patients with CRC. Two reviewers independently extracted individual study data and evaluated THE risk of bias among the studies using the Newcastle‒Ottawa Scale. To examine a potential nonlinear relationship between the year of HRT use and CRC mortality, we performed a two-stage random effects dose‒response meta-analysis.
RESULTS
Ten cohort studies encompassing 480,628 individuals were included. The meta-analysis revealed that HRT was inversely associated with the risk of CRC mortality [hazard ratios (HR) = 0.77, 95% CI (0.68, 0.87), I2 = 69.5%, P < 0.05]. Pooled results from seven cohort studies revealed a significant association between HRT and the risk of all-cause mortality [HR = 0.71, 95% CI (0.54, 0.92), I2 = 89.6%, p < 0.05]. A linear (P for nonlinearity = 0.34) dose‒response analysis showed a 3% decrease in the risk of CRC for each additional year of HRT use; this decrease was significant [HR = 0.97, 95% CI(0.94, 0.99), P < 0.05]. An additional linear (P for nonlinearity = 0.88) dose‒response analysis showed a nonsignificantly decrease in the risk of all-cause mortality for each additional year of HRT use.
CONCLUSIONS
This study suggests that the use of HRT is inversely associated with all-cause and colorectal cancer mortality, thus causing a significant decrease in mortality rates over time. Further studies are warranted to confirm this association.
Vascular regeneration and skeletal muscle repair induced by long-term exposure to SDF-1α derived from engineered mesenchymal stem cells after hindlimb ischemia
Authors: Park Hun-Jun , Kim Jin-Ju , Park Jae-Hyun , Kim Hyeok , Sim Woo-Sup , Hong Seokbeom , Choi Yeon-Jik , Kim Hyo-Jin , Lee Soon Min , Ban Kiwon 
Published: January 2023

Abstract
Despite the recent progress in medical and endovascular therapy, the prognosis for patients with critical limb ischemia (CLI) remains poor. In response, various stem cells and growth factors have been assessed for use in therapeutic neovascularization and limb salvage in CLI patients. However, the clinical outcomes of cell-based therapeutic angiogenesis have not provided the promised benefits, reinforcing the need for novel cell-based therapeutic angiogenesis strategies to cure untreatable CLI patients. In the present study, we investigated genetically engineered mesenchymal stem cells (MSCs) derived from human bone marrow that continuously secrete stromal-derived factor-1α (SDF1α-eMSCs), and demonstrated that intramuscular injection of SDF1α-eMSCs can provide long-term paracrine effects in limb ischemia and effectively contribute vascular regeneration as well as skeletal muscle repair through increased phosphorylation of the ERK and Akt within the SDF1α/CXCR4 axis. These results provide compelling evidence that genetically engineered MSCs with SDF-1α can be an effective strategy for successful limb salvage in limb ischemia.
Congenital hepatic hemangioma: An unusual case report of pulmonary hypertension
Authors: Zhou Qianqin , Juan Jiang , Xu Yinquan , Qiu Hanyan , Wen Xiaoyan , He Shaoqi , Lv Qin 
Published: January 2023

Abstract
Background: Pulmonary hypertension (PH) in a newborns is a rare but serious condition that often requires immediate intervention and quick diagnosis of the correct etiologyto prevent mortality. Congenital hepatic hemangioma (CHH) is an example of an extrathoracic etiology of PH.
Case presentation: Herein, we report the case of a newborn with a giant liver hemangioma, who presented with an early onset of PH and was successfully treated with intra-arterial embolization.
Conclusions: This case illustrates the importance of suspicion and prompt evaluation of CHH and related systemic arteriovenous shunts among infants with unexplained PH.
Optimization of mullite-based chamotte production as a result of calcination of a kaolin-boron waste mixture by response surface method and its usability in ceramic
Authors: Bulut Firdevs , Taşdemir Tuba , Tatar İlknur 
Published: January 2023

Abstract
This study aims to use kaolin and boron waste in the production of Chamotte material. The usability of the produced chamotte in the FFC (fine fire clay) body in sanitary wares, instead of the chamotte supplied from abroad, was also investigated. The studies were carried out using a statistical experimental design and aimed to reach more information with a small number of experiments. The percentage of boron content, calcination temperature and grinding time factors were examined as independent variables, and the effects of these factors on the percentage of mullite phase, anorthite phase, quartz phase and sodium aluminum silicate phase were examined. Thus, the interaction of the parameters both individually and with each other was revealed, and the process was modeled with a mathematical model that is a function of independent variables. In addition, with an optimization study that provides the desired product feature with the least possible cost, the properties of the vitrified product obtained with both the produced chamotte and the reference chamotte were compared. When the chamotte, produced by optimizing the experimental design, was added to the vitrified body, this product achieved an improvement 32.73% in strength, 5.88% in shrinkage, and 4.67% in water absorption compared to the reference factory chamotte. As a result, with the current study, it has been determined that when both waste kaolin and boron are calcined together, fireclay with better properties can be obtained instead of imported fireclay and can be used industrially.
Labour market participation after a sickness absence due to cancer: a dynamic cohort study in Catalonia (Spain)
Authors: Ayala-Garcia Amaya , Benavides Fernando G. , Serra Laura 
Published: January 2023

Abstract

Background: The consequences of cancer on working life until retirement age remain unclear. This study aimed to analyse working life considering all possible labour market states in a sample of workers after an SA due to cancer, and to compare their working life paths to those of a sample of workers without SA and with an SA due to other diseases.
Methods: Registry-based cohort study of social security affiliates in Catalonia from 2012-2018. Cases consisted of workers with an SA due to cancer between 2012-2015 (N=516) and were individually age- and sex-matched with an affiliate with an SA due to other diagnoses and a worker without an SA. All workers (N=1,548, 56% women) were followed-up from the end of the SA due to cancer until the end of 2018 to characterise eight possible weekly labour states. Sequence analysis, optimal matching, and multinomial logistic regression were used to identify and assess the probability of future labour market participation patterns (LMPP). All analyses were stratified by sex.
Results: Compared with workers with an SA due to cancer, male workers with no SA and SA due to other causes showed a lower probability of being in the LMPP of death (aRRR 0.02, 95% CI: 0.00‒0.16; aRRR 0.17, 95% CI: 0.06‒0.46, respectively), and in women lower probability of increasing permanent disability and death (aRRR 0.24, 95% CI: 0.10‒0.57; aRRR 0.39, 95% CI: 0.19‒0.83, respectively). Compared to workers with SA due to cancer, risk of future retirement was lower in workers with no SA (women aRRR 0.60, 95%CI: 0.22‒1.65; men aRRR 0.64, 95%CI: 0.27‒1.52).
Conclusions Workplaces should be modified to the needs of cancer survivors, many of which are common to all diagnoses, in order to prevent more frequent retirement and permanent disability when possible. Further studies should assess the impact of cancer on premature exit from the labour market among survivors, depending on cancer localisation and type of treatment.
Single-cell sequencing reveals increased LAMB3+ basal keratinocytes and ZNF90+ fibroblasts in autologous cultured epithelium under serum- and feeder-free conditions
Authors: Lian Weiling , Zeng Xuanhao , Li Jian , Liu Yating , Lv Haozhen , Chen Shujun , Huang Shiyi , Shen Jiayi , Zang Qing , Tang Luyan , Wu Fuyue , Zhang Qi , Xu Jinhua 
Published: January 2023

Abstract
Autologous cultured epithelium grafting (ACEG) is a promising treatment for refractory vitiligo. Concerns for infections or immunological reactions caused by serum and feeder used in culture medium may limit the use for surgical interventions. Here, we cultured autologous epithelium under serum- and feeder-free (SFF) conditions and compared its safety and efficacy with epithelium cultured under serum- and feeder-dependent (SFD) conditions in patients with stable vitiligo. Then, single-cell RNA transcriptomics of SFF and SFD cultured epithelium and healthy skin were conducted. There were no significant differences in repigmentation between the SFF and the SFD conditioned grafting. Increased LAMB3 + basal keratinocytes and ZNF90 + fibroblasts were found in the SFF epithelial sheets. The LAMB3 + basal keratinocytes had active cellular metabolism and participated in extracellular matrix homeostasis. The ZNF90 + fibroblasts were more differentiated and implicated in collagen formation for cell adhesion. Both the LAMB3 + basal keratinocytes and the ZNF90 + fibroblasts were more involved in the interactions with melanocytes in the SFF epithelial sheets compared to the SFD epithelial sheets. Our findings support the LAMB3 + basal keratinocytes and the ZNF90 + fibroblasts as key factors behind the repigmentation in ACEG under SFF conditions. The study provides translational insights into ACEG repigmentation and potential therapeutic targets for vitiligo.
Palaeo-environmental reconstruction of pedogenic calcretes in Sathankulam, Southern India: an integrated approach
Authors: Velmayil Perumal , Venu Udayanapillai Alagaiah 
Published: January 2023

Abstract

A widespread and thick calcrete level occurs as an intervening deposit between soil surface and Proterozoic hard metamorphic granite (or) Tertiary calcareous sandstone basement rocks of Sathankulam region, Thoothukudi district of Tamilnadu, India. Field observation reveals the nature of calcrete deposits as gravel, chalky, laminated, massive, and nodular forms. Photomicrographs of calcrete thin sections reveal calcified macrocystis, calcified fungal hyphae, calcified microtubules, peloidal, calloforms with clay clast rimmed by micritic calcite, sesquioxide preservation and micritic calcite preservation in septarian nodules. X-ray diffraction analysis of calcrete profile samples reveals predominance of micritic calcite and limited occurrence of clay minerals of sepiolite, palygorskite, and other grains of quartz, feldspar, hornblende, biotite, and gypsum. Geochemical studies of two calcrete profile samples show the predominance of major elements of CaO, Al2O3, MgO, Fe2O3, minor/trace elements of Ba, Nb, Zr, Y, Sr, Rb, Ga, Zn, Ni, Cu, and Cr and rare earth elements/chondrite values of La, Ce, Pr, Nd, Sm, Gd, and Dy. Statistical evaluation of all major, minor/trace, and rare earth elements through multiple correlations, principal component analysis, and cluster analysis establish the inter-relationship and affinities between the parameters of the source elements of the two profiles. Stable isotope study of δ13C and δ18O of Hudson diagenitic plot study reveals that the two calcrete profile samples represent the reconstruction of palaeo-diagentic environmental condition as meteoric cement and continental freshwater limestone depositional environment. Further, stable isotope analysis of the area plotted on Julian Andrews and Keith and Weiber standard plot represents the weaker monsoonal climate and meteoric-diagenetic environment respectively.
Posterior cerebral artery infarction associated with Mycoplasma pneumoniae infection in children
Authors: Li Jian , Miao Hongjun , Wang Jun , Chen Dongmei , Wu Lihui , Fang Yongjun 
Published: January 2023

Abstract

Acute ischemic stroke is a rare neurological complication of mycoplasma (MP) infection in children. We present two children with a MP respiratory infection who experienced posterior cerebral circulation stroke, which is particularly rare, and review the relevant literature. Both cases were pre-school children who initially acquired a respiratory illness then developed neurological signs including coma and seizure. Chest radiography revealed pneumonic infiltration with pleural effusion or pleural response. Anti-MP IgM antibody was positive. MP DNA was detected in the sputum using polymerase chain reaction analysis. Cerebrospinal fluid biochemical and pathological testing and MP DNA analysis were negative. D-dimer concentration was elevated. Neuroimaging showed posterior circulation occlusion and infarction. Clinical symptoms improved after treatment with erythromycin, anticoagulation, and thrombolysis; however, neurological sequelae remained and follow-up imaging revealed permanent effects. In our literature review, we identified 25 patients (including the two presented here) who developed an ischemic stroke as a complication of MP infection, 14 males and 11 females. Median age was six years (range, zero to 13) and average time between respiratory symptoms and stroke onset was 9 days. Nineteen strokes (76%) involved the anterior cerebral circulation; middle cerebral artery stroke was most prevalent (68%). Hemiparesis and seizure were the most common neurologic signs. Evidence of MP infection was found in the cerebrospinal fluid of five children. Coagulopathy affected nearly half. The most common treatments were macrolide antibiotics, immunoglobulin, glucocorticoid, and aspirin. Three patients (11%) died during follow-up, all from early respiratory deterioration. Thirteen children had varying degrees of permanent neurological sequelae. Cerebral infarction is a rare complication of MP infection in children and has a poor prognosis. Early identification of stroke risk factors and early intervention may improve outcomes.
A Model of Band Gaps and Ionicity in Crystal
Authors: Pathak Mritunjai Kumar , Dutta Madhu Sudan , Gorai Sanjay Kumar , Gupta Ashok Kumar , Sinha Rajendra Nath , Mahto Parmanand 
Published: January 2023

Abstract
A new and simple model of homopolar and heteropolar band gaps and ionicity is presented which overcomes the discrepancies of PVL (Philips, Van Vechten and Levine) theory and also of the other scales, results of which are not in conformity with the findings of hardness/bulk modulus reported in recent years. The proposed model requires the knowledge of bond length as the only input parameter and avoids the demand of additional parameters obtained from the detailed crystal structure as required in PVL theory. It has been applied to group-IV and IV-IV, IV-VI, III-V, II-VI and I-VII semiconductors of Zinc blende/wurtzite and rocksalt structures and group II-VI and I-VII ionic compounds of rocksalt and cesium chloride structures. It has also been utilised to evaluate ionicity of boron-boron bonds in B12 icosahedra. One critical and two sub-critical ionicities have also been proposed in this study. Besides, a new relation is proposed for direct evaluation of heteropolar band gap in terms of homopolar band gap of the materials studied. Results of the new model are in conformity with the trend of bulk modulus/ hardness reported and also of bond length. The proposed model has further been extended to ternary (I-III-VI2 and II-IV-V2) semiconductors and multibond high Tc – Superconductor, YBa2Cu3O7. Results obtained are quite reasonable.
Radiomics nomogram for preoperative differentiation of pulmonary mucinous adenocarcinoma from tuberculoma in solitary pulmonary solid nodule
Authors: Zhang Junjie , hao ligang , qi mingwei , xu qian , zhang ning , feng hui , shi gaofeng 
Published: January 2023

Abstract
Objective: To develop and validate predictive models using clinical parameters, radiomic features and a combination of both for preoperative differentiation of pulmonary nodular mucinous adenocarcinoma (PNMA) from pulmonary tuberculoma (PTB).
Method：A total of 124 and 53 patients with PNMA and PTB, respectively，were retrospectively analyzed from January 2017 to November 2022 in The Forth Affiliated Hospital of Hebei Medical University. A total of 1037 radiomic features were extracted from the contrast enhanced computed tomography (CT). Patients were randomly divided into training group and test group at a ratio of 7:3. The least absolute shrinkage and selection operator (LASSO) algorithm was used for radiomic feature selection. Three radiomics prediction models were applied: Logistic Regression (LR), Support Vector Machine (SVM) and Random Forest (RF). The best performing model was adopted, and the radiomics score (Radscore) was then computed. The clinical model was developed using logistic regression. Finally, a combined model was established based on clinical factors and radiomics features. The area under the receiver operating characteristic (ROC) curve (AUC) value and decision curve analysis were used to evaluate the predictive value of developed models.
Results：Combined clinical and radiomics models established by Logistic Regression method had the best performance. The ROC-AUC (also decision curve analysis) of combined model were 0.940 and 0.990 in the training group and test group, respectively, which showed a good predictive performance for differentiation of PNMA from PTB. Briser Score of the combined model were 0.132 and 0.068 in the training group and test group, respectively.
Conclusion: The combined model incorporating radiomics features and clinical parameters may have potential value for preoperative differentiation of PNMA from PTB.
Alleviating iatrogenic effects of paclitaxel via anti-inflammatory treatment
Authors: Zhang Mengwei , Lotfollahzadeh Saran , Elzinad Nagla , Yang Xiaosheng , Elsadawi Murad , Gower Adam , Belghasem Mostafa , Shazly Tarek , Kolachalama Vijaya B. , Chitalia Vipul 
Published: January 2023

Abstract
Background
Paclitaxel is touted as an essential medicine due to its extensive use as a chemotherapeutic for various cancers and an antiproliferative agent for restenosis. Due to recent concerns related to long-term mortality, paclitaxel (PTX)-based endovascular therapy is now surrounded by controversies.
Objective
Examine the inflammatory mediators driven by the systemic administration of PTX and explore the means to suppress these effects.
Methods
RNAseq analysis, cell and mouse models.
Results
RNAseq analysis of primary human endothelial cells (ECs) treated with PTX demonstrated transcriptional perturbations of a set of pro-inflammatory mediators, including monocyte chemoattractant protein-1 (MCP-1) and CD137, which were validated in EC lysates. These perturbations were abrogated with dexamethasone, a prototypic anti-inflammatory compound. The media of ECs pre-treated with PTX showed a significant increase in MCP-1 levels, which were reverted to baseline levels with DEX treatment. A group of mice harvested at different time points after PTX injection were analyzed for immediate and delayed effects of PTX. A 3-fold increase in MCP-1 was noted in blood and aortic ECs after 12 hours of PTX treatment. Similar changes in CD137 and downstream mediators such as tissue factor, VCAM-1 and E-selectin were noted in aortic ECs.
Conclusions
Our study shows that systemic PTX exposure upregulates atherothrombotic markers, and co-delivery of DEX can subdue the untoward toxic effects. Long-term studies are needed to probe the mechanisms driving systemic complications of PTX-based therapies and evaluate the clinical potential of DEX to mitigate risk.