bluuebunny/crossref_metadata_2025_split huggingface dataset:
URGENSI DAN PERAN LEMBAGA KEUANGAN MIKRO DALAM PENGENTASAN KEMISKINAN DAN PENGEMBANGAN EKONOMI UMAT
Authors: Suaidah Suaidah , Arjun Devi 
Published: May 2023

Layanan keuangan mikro semakin meningkat dan telah menjadi intervensi yang populer melawan kemiskinan di negara berkembang. Kemampuan Lembaga Keuangan Mikro telah teruji melalui masa krisis moneter yang sangat sulit dan terbukti secara riskan mampu memberdayakan perekonomian kecil dan menengah. Oleh karena itu, peneliti ingin mengkaji bagaimana peran LKM dalam pengentasan kemiskinan dan pengembangan pemberdayaan ekonomi umat. Karena LKM saat ini semakin berkembang serta telah membawa perubahan yang mendasar pada strategi sosialisasi. Metode penelitian bersifat penelitian kualitatif dengan menggunakan pendekatan studi pustaka. Hasil dari penelitian menemukan bahwa salah satu peran yang sangat besar dalam pengentasan kemiskinan saat ini adalah BMT yang saat ini masih dipercaya oleh masyarakat. Hal ini diminati, karena lembaga keuangan syariah oleh umat Islam bahkan umat non muslim sekalipun, sebab berprinsip jujur, adil dan baik yang selalu menjadi daya tarik masyarakat.
A Non-targeted Metabolomics Reveals Therapeutical Effect and Mechanism of
Sanmiao Pill on Adjuvant-induced Arthritis Rats
Authors: Cao Dongdong , Yang Le , Gao Xin , Huang Danna , Zhan Xiaoning , Qiu Shi , Sun Hui , Yan Guangli , Wang Xijun 
Published: May 2023

Background and Objective:
Rheumatoid arthritis (RA) is an increasingly serious disease worldwide
that can damage the joints and bones of sufferers. Sanmiao Pill (SMP), a classical traditional Chinese medicine
(TCM) prescription, has been used for effective treatments for RA in the clinic. To comprehensively illuminate
the therapeutic mechanism of SMP in the treatment of RA, the effects of SMP on biomarkers and metabolic
pathways in rats with adjuvant-induced arthritis (AIA) were examined.

Methods:
Sprague Dawley rats were randomly divided into two control (CC, Control) groups, two model (MM,
Model) groups, a methotrexate group (MTX, 7.6 mg/kg body weight per week), and two SMP groups (San-L,
28.7 mg/kg body weight per day and San-H, 57.4 mg/kg body weight per day). Rats' body weight, paw
swelling, arthritis scores, biochemical parameters, histopathology, and so on were used to evaluate the success
of the model and the therapeutic effects of SMP. The metabolic techniques were used to characterize the
metabolic profile and biomarkers of the serum and urine samples of rats to reveal the metabolic changes that occurred
after SMP treatment.

Results:
After 21 days of treatment, SMP improved weight gain, reduced the severity of paw swelling, lowered
the levels of biochemical indicators (CCP-Ab, IL-6, TNF-α, RF), decreased destruction of articular cartilage
and bone erosion, and protected the affected joints.Additionally, 17 and 19 potential biomarkers associated with
RA were identified in the serum and urine, respectively. SMP significantly reversed 14 potential biomarkers,
such as arachidonic acid, lysoPC(20:4(5Z,8Z,11Z,14Z)), L-tryptophan, 9-cis-Retinoic acid, hippuric acid, pyridoxine,
and pantothenic acid. These metabolites are associated with arachidonic acid metabolism, glycerophospholipid
catabolism, tryptophan metabolism, phenylalanine metabolism, vitamin B6 metabolism, etc.

Conclusion:
These results indicated that RA-related biomarkers reflected the metabolic profile of AIA rats.
Meanwhile, SMP could effectively treat RA mainly by reducing inflammation and regulating abnormal lipid
metabolic pathways and amino acid metabolisms. It showed that metabolomics could be used to analyze the
metabolic profiles involved in RA and reveal the mechanism of SMP treatment of RA.
siRNA Mediated Downregulation of RhoA Expression Reduces
Oxidative Induced Apoptosis in Retinal Ganglion Cells
Authors: Liu Qian , Liu Changgeng, , Lei Bo 
Published: May 2023

Backgrounds:
Glaucoma is the second leading cause of blindness. Apoptosis of retinal ganglion cells (RGCs) is an important mechanism of glaucomatous optic injury. Rho kinase expression is significantly increased in apoptotic RGCs. This study aimed to investigate the role of RhoA, a Rho GTPase, on the survival of RGCs and further to explore its potential therapeutic applications.

Methods:
RGCs were treated with siRhoA for 24 hours in vitro. Knockdown of RhoA was confirmed with quantitative RT-PCR. Oxidative stress was induced by treating the RGCs with 200 μM of H2O2 for 1 hour, and apoptosis of RGCs was quantified with TUNEL assay in situ, and with flow cytometry. The mRNA expression levels of RhoA, Nogo receptor, caspase 3 and Bcl-2 were evaluated by quantitative RT-PCR, and the protein levels of RhoA, ROCK1, ROCK2, Nogo receptor, caspase 3 and Bcl-2 were evaluated by Western blot. We found siRhoA treatment efficiently downregulated the expression of RhoA in RGCs and protected against H2O2-induced injury in RGCs in vitro. Apoptosis of RGC cells under oxidative stress was quantified in situ using TUNEL assay and confirmed with flow cytometry (FCM).

Results:
With the knockdown of RhoA, the expression of ROCK1, ROCK2, Nogo Receptor, Casepase-3 were decreased, while the expression of Bcl-2 was increased in both mRNA and protein level. Our data indicated that siRhoA prevented H2O2-induced apoptosis in RGC cells by modulating the RhoA/ROCK pathway.

Conclusion:
The results suggested that siRhoA may exert potentially effective neuroprotection for RGCs by reducing injury.
An Extensive Review of MR Sensors with Design and Characteristic
Evaluation of Three-layered TMR Sensor
Authors: Gayathri Subramanian Vimala , Subbulekshmi Durairaj 
Published: May 2023

Abstract:
The reliability and efficacy of sensor-based automated systems have improved due to
the proliferation of electric vehicles, renewable sources, and integrated systems in power industries
extensively. This has been accomplished by increasing the power density and decreasing the volume
of the system.

Background:
Mathematical estimation and comparative analysis of the physical factors result in
massive usage of operational matrices measured using sensors. Magnetic field sensors, used in
industries and biomedical applications, have a high level of precision in the evaluation of measurements.
In order to extract the measured parameters such as sensitivity, accuracy, operating cost,
the linear range of operation, and power utilisation, these sensors adhere to the physical constraints
during their nominal working conditions. The characteristics of the aforementioned sensors are
enumerated in detail in this article.

Objective:
This objective is highly focused on providing a comprehensive overview of classification
and the properties of Hall-Effect, anisotropic magnetoresistive (AMR), giant magnetoresistive
(GMR), and tunnelling magnetoresistive (TMR) sensors. The dissertation on its properties concludes
that TMR is more reliable and sensitive in variable operating conditions.

Methods:
The methods for selecting the sensors for an application are confined to voltage
fluctuations and sensitivity. A three-layered TMR sensor with two magnetic layers and an insulator
in between is proposed as a significant advancement compared to the literature. The micromagnetic
simulation is carried out at room temperature for a three-layered TMR made up of neodymium
alloy, magnesium oxide, and cobalt platinum alloy.

Conclusion:
Based on the studies executed, it is determined that TMR is more sensitive than both
conventional and MR sensors. The proposed schematic claims that the higher free layer thickness
offers maximum sensitivity with 77% negative magnetoresistance. The reduced coercivity of
1.9Oe is achieved in this combination at a specified temperature range.
Italian Guidelines for the Management of Prolactinomas
Authors: Cozzi Renato , Simona Auriemma Renata , De Menis Ernesto , Esposito Felice , Ferrante Emanuele , Iatì Giuseppe , Mazzatenta Diego , Poggi Maurizio , Rudà Roberta , Tortora Fabio , Cruciani Fabio , Mitrova Zuzana , Saulle Rosella , Vecchi Simona , Basile Michele , Cappabianca Paolo , Paoletta Agostino , Papini Enrico , Persichetti Agnese , Samperi Irene , Scoppola Alessandro , Bozzao Alessandro , Caputo Marco , Doglietto Francesco , Ferraù Francesco , Lania Andrea Gerardo , Laureti Stefano , Lello Stefano , Locatelli Davide , Maffei Pietro , Minniti Giuseppe , Peri Alessandro , Ruini Chiara , Settanni Fabio , Silvani Antonio , Veronese Nadia , Grimaldi Franco , Attanasio Roberto 
Published: May 2023

Introduction:
This guideline (GL) is aimed at providing a reference for the management of prolactin (PRL)-secreting pituitary adenoma in adults. However, pregnancy is not considered.

Methods:
This GL has been developed following the methods described in the Manual of the Italian National Guideline System. For each question, the panel appointed by Associazione Medici Endocrinologi (AME) has identified potentially relevant outcomes, which have then been rated for their impact on therapeutic choices. Only outcomes classified as “critical” and “important” have been considered in the systematic review of evidence and only those classified as “critical” have been considered in the formulation of recommendations.

Results:
The present GL provides recommendations regarding the role of pharmacological and neurosurgical treatment in the management of prolactinomas. We recommend cabergoline (Cab) vs. bromocriptine (Br) as the first-choice pharmacological treatment to be employed at the minimal effective dose capable of achieving the regression of the clinical picture. We suggest that medication and surgery are offered as suitable alternative first-line treatments to patients with non-invasive PRL-secreting adenoma, regardless of size. We suggest Br as an alternative drug in patients who are intolerant to Cab and are not candidates for surgery. We recommend pituitary tumor resection in patients 1) without any significant neuro-ophthalmologic improvement within two weeks from the start of Cab, 2) who are resistant or do not tolerate Cab or other dopamine-agonist drugs (DA), 3) who escape from previous efficacy of DA, and 4) who are unwilling to undergo a chronic DA treatment. We recommend that patients with progressive disease notwithstanding previous tumor resection and ongoing DA should be managed by a multidisciplinary team with specific expertise in pituitary diseases using a multimodal approach that includes repeated surgery, radiotherapy, DA, and possibly, the use of temozolomide.

Conclusion:
The present GL is directed to endocrinologists, neurosurgeons, and gynecologists working in hospitals, in territorial services or private practice, and to general practitioners and patients.
On models of ground vibrations in strong earthquakes
Authors: Zainulabidova H. R. , Toturbieva U. Dz. , Jamaludinov A. M. 
Published: May 2023

Objective. The purpose of these studies is to determine, on the basis of the developed models describing seismic impacts, the most acceptable for acceptance from the point of view of the accuracy of the description of the seismic oscillation both in the shape of the envelope and in duration and frequency characteristics.Method. The use of empirical models in describing soil fluctuations as a random process has been considered in a number of papers. This paper presents the main simplifying assumptions used in this approach. The validity of empirical models and some difficulties encountered in modeling the oscillation process are investigated.Result. A methodology for assessing the reliability of the proposed impact models is proposed. The proposed method takes into account the soil - geological characteristics, as well as spectral data of instrumental recordings of known earthquakes.Conclusion. The seismic impact model, as well as the approximating modeling function, should be determined by the degree of responsibility of the building.
Construction and technical properties of vermiculite concrete and fibro vermiculite concrete with volcanic pumice under the influence of elevated temperatures
Authors: Khezhev T. A. , Khadzhishalapov G. N. , Zhurtov A. V. , Shogenova F. M. , Kalazhokov A. V. 
Published: May 2023

Objective. Development of compositions of vermiculite concrete and fibro vermiculite concrete with volcanic pumice. Investigation of the construction and technical properties of the developed compositions of vermiculite concrete and fibrovermiculite concrete with volcanic pumice under the influence of elevated temperatures.Method. Methods of increasing the fire resistance of reinforced concrete structures are considered. The research is aimed at the development of vermiculite concrete and fibro vermiculite concrete with volcanic pumice for fire protection of building structures and the manufacture of heat-resistant products and structures. To reduce the cost of vermiculite concrete, its partial replacement with volcanic pumice is proposed. For the study of vermiculite concrete with volcanic pumice reinforced with basalt fiber, a rotatable plan of the second order of the regular hexagon type was used.Result. Replacing a part of an expensive aggregate (expanded vermiculite) with pumice leads to a slight increase in the average density of the composite, while the bending and compressive strength increases. In addition, the heat-resistant properties of vermiculite concrete with pumice are increased. This is due to the fact that volcanic pumice, being a hydraulically active additive, is able to react hydration with cement components, eliminating the harmful effect of secondary hydration of free calcium oxide. The influence of the heating temperature on the change in the construction and technical properties of vermiculite concrete and fibrovermiculic concrete, including with the addition of pumice, has been studied. It was found that dispersed reinforcement with basalt fibers reduces shrinkage deformations, when heated to t = 800, the shrinkage decreases from 0.7 to 0.5% compared to the original concrete matrix.Conclusion. The dependence "compressive strength = f (average concrete density)" significantly depends on the presence and ratio of pumice in the composition of vermiculite concrete, while an increase in the holding temperature to 600 oC or 800 oC leads to a decrease in the compressive strength from 15 to 25%, and the main decrease occurs when heated to 600 oC, further the increase in temperature has a negligible effect. The dependence of the bending strength on the compressive strength is generally maintained regardless of the heating temperature, and the heating of concrete does not reduce the relative bending strength, i.e. the ratio of bending strength / compressive strength is not reduced. Dispersed fiber reinforcement increases the relative bending strength by about 70% regardless of the heating temperature.
Optimization of thermoelectric temperature control systems
Authors: Semilyak A. I. , Sarkarov T. E. , Evdulov D. V. , Nazarov K. K. 
Published: May 2023

Objective. The aim of the study is to study the methods of temperature control using the Peltier element in a given temperature range.Method. A heating method is applied using a Peltier element in a temperature control device of a small plate by regulating the current and using a cooling fan to reduce inertia.Result. A technique for controlling the Peltier element to maintain the required temperature is obtained, which is carried out using the PWM method generated by the ATmega2560 processor. The H-bridge on the L6203 integrated circuit switches the current direction and can control the current up to 5A on the Peltier element using a PWM signal.Conclusion. The resulting control algorithm provides an increase in the heating current on the Peltier until the temperature rises to a predetermined high temperature value, and then by changing the direction of the current, a cooling current is created on the Peltier element until the temperature of the copper plate drops to a predetermined low temperature. With repeated repetition of this sequence, the regularity of temperature changes is monitored to study the process of heating and cooling the plate using the Peltier element.
Assessment methodology for security of an automated control system of critical information infrastructure against DDoS attacks based on Monte Carlo simulation
Authors: Voevodin V. A. , Chernyaev V. S. , Burenok D. S. , Vinogradov I. V. 
Published: May 2023

Objective. The purpose of the study is to develop a methodology for assessing the security of an automated control system of critical information infrastructure from DDoS attacks. The purpose of the methodology development is to provide the decision–maker with a scientifically sound tool for assessing the risk of implementing a DDoS attack.Method. To achieve the stated goal of the study, simulation modeling based on the Monte Carlo method was used.Result. The expediency of using Monte Carlo simulation to assess the probability of server failure under DDoS attacks is confirmed. It was concluded that the server can be considered as a queuing system, however, the flow of incoming applications under DDoS attacks is not Poisson, so the use of analytical expressions to assess the probability of failure is considered incorrect. The simulation results allow the decision-maker to assess the probability of server failure and make organizational and technical decisions to increase the level of security. Analysis of the simulation results showed the effectiveness of improving server performance by increasing service channels.Conclusion. Thus, the developed methodology will be useful in conducting an information security audit of an organization to justify the amount of its insurance premium in the framework of cyber risk insurance. A possible direction for further research is to study the issue of computer network security, taking into account the features of a specific topology.
Application of existing algorithms for classification and clustering of laser reflection points (k-Means, DBSCAN, SVM) to solve territorial planning problems
Authors: Gura D. A. , Boltovnina O. S. 
Published: May 2023

Objective. The aim of the study is to generalize the experience of using and reveal the features of methods for classifying and clustering images obtained by laser scanning.Method. The study is based on the use of algorithms for recognition, clustering and classification of data obtained using laser scanning.Result. A brief review of existing algorithms used for clustering images obtained by laser scanning has been carried out. The possibility of using sequentially the K-means and DBSCAN algorithms for clustering in relation to objects of various shapes is shown. The possibilities of using algorithms for the classification and clustering of laser reflection points (k-Means, DBSCAN, SVM) in the framework of solving territorial planning problems are analyzed.Conclusion. The use of the presented algorithms makes it possible to form data arrays that, when superimposed on each other subsequently and further processed, make it possible to obtain even more accurate representations of objects and territories in territorial planning documents, and in the future, based on the use of machine learning methods and processing of data matrices available in memory, get more accurate information about objects on the ground.
Correlation of Processing Techniques with Some Quality Indexes of Soy-Akamu Prepared with Yellow Maize, Sprouted and Un-Sprouted Soybean
Authors: Okwunodulu Innocent Nwazulu , Ugochukwu Chikodili , Ndife Joel , Ubbor Stella 
Published: May 2023

Akamu or ogi is a commonly relished gruel when prepared with hot water by the sick, recovering patients and infants in Nigeria. It is nutritionally deficient due to inevitable processing losses which called for fortification with soybean (soy-akamu or soy-ogi). Soy-akanu was prepared from steeped yellow maize, sprouted and un-sprouted soybean cotyledons using different processing techniques. Proximate, micronutrients and functional properties were evaluated with standard analytical methods. The results showed that proximate composition of soy-akamu produced from dried steeped maize and sprouted soybean cotyledons had higher protein (63.20%), fibre (0.33%), ash (1.11%), energy (384.28 Kcal) and least moisture content (4.53%). The paste samples had respective values of 0.77, 3.06%; 0.00, 0.00%; 0.71, 1.02%; 29.86, 3303%; 143.50, 145.37 mg/100g, and 64 and 36-64-76%. Dried soy-akamu also had the highest calcium (41.18, iron (0.99), phosphorous (0.27), .zinc (48.02), potassium (0.45), vitamin C (24.60) and least in magnesium (0.07 mg/100g) content. The paste samples had respective values of 40.13, 41.14; 0.86, 0.92; 0.39, 0.41; 0.39, 0.41; 20.46, 23.65 mg/100g with respective magnesium (0.10-0.12) and phosphorous ( 0.25, 2.21 mg/100g) contents. Different processing techniques had significant (p<0.05) variations in proximate, micronutrient and functional properties of the soy-akamu and also their major sources of nutrient losses.
Mimetic Reading of J.K. Rowling’s The Casual Vacancy: A Political Critique of the United Kingdom’s 2010 General Election Through the Analysis of Children Characters’ Sufferings
Authors: Sugiyanto Levina Elsa Prastiwi , Rohman Moh. Arif 
Published: May 2023

In 2010, the United Kingdom called on a General Election after the Queen agreed to grant an approval to Gordon Brown’s proposal to dissolve the parliament. The Queen’s approval resulted on prorogation marking the end of Gordon Brown’s parliamentary period. The General Election was used as a stage for the United Kingdom’s three biggest parties to assert their political dominance. Publishing her first novel for adult, The Casual Vacancy, J.K. Rowling attempted to deliberate the change of political atmosphere during the major event.The recent paper employs Paul Ricoeur’s Threefold Mimesis to analyse the symbolisms presented in The Casual Vacancy in order to demonstrate how it is used as a means of constructive criticism of the three biggest parties participating in the UK’s 2010 General Election. The criticism mentioned in this paper are based on writer’s interpretation. Those are the Conservative needs to evaluate its rigid, too right-winged, outdated policies and to expunge its tendency of establishing class-exclusivity, Labour Party needs to evaluate its members and to pay more attention to its supporters’ concerns; Liberal-Democrats needs to resolve its scandals and to be more selective in postulating its candidates. Details are discussed.
Studi Perilaku Pencarian Informasi Kesehatan oleh Generasi Z Terkait Vaksinasi Covid-19
Authors: Hisan Urfa Khairatun 
Published: May 2023

Di Daerah Istimewa Yogyakarta (DIY), jumlah peserta vaksin dosis 3 hanya sebanyak 27.31% dari target sasaran vaksinasi. Informasi memiliki peran penting dalam pengendalian COVID-19. Disinformasi mengenai COVID-19 mempengaruhi penerimaan seseorang terhadap vaksinasi. Generasi Z merupakan individu yang lahir antara tahun 1995 dan 2012. Studi ini bertujuan untuk mengeksplorasi bagaimana perilaku generasi Z di DIY dalam pencarian informasi vaksinasi COVID 19. Studi kuantitatif ini menggunakan teknik convenience sampling. Responden merupakan generasi Z di DIY. Pengumpulan data dilakukan menggunakan google form dan didapatkan 129 responden yang memenuhi kriteria. Hasilnyaadalah 81.0% responden melakukan pencarian informasi kesehatan terkait vaksinasi COVID-19 selama <1 jam dalam sehari. Motivasi utama responden adalah karena mereka berencana mendapatkan vaksinasi. 83.72% orang menggunakan media sosial sebagai sumber informasi, dan Instagram merupakan media sosial yang paling banyak digunakan (85.27%). 60.47% orang percaya dengan informasi yang didapatkan dan 71.32% orang merasa mampu membedakan informasi yang valid dan invalid. Kesulitan yang paling sering ditemui disebabkan oleh adanya penyebaran berita palsu (55.04%). Generasi Z menggunakan media sosial sebagai sumber informasi utama dalam memperoleh informasi vaksinasi COVID-19 dengan alasan kemudahan akses. Namun, kemudahan tersebut juga menimbulkan tantangan yang sering ditemui berupa penyebaran berita palsu.