bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous allocation of renewable energy sources and custom power quality devices in electrical distribution networks using artificial rabbits optimization
Authors: Chegudi Ranga Rao , Ramadoss Balamurugan , Alla Ramakoteswara Rao 
Published: August 2023

Abstract
This study suggests an optimal renewable energy source (RES) allocation and distribution-static synchronous compensator (D-STATCOM) and passive power filters (PPFs) for an electrical distribution network (EDN) to improve its performance and power quality (PQ). First, the latest metaheuristic artificial rabbits optimization (ARO) is used to locate and size solar photovoltaic (PV), wind turbine (WT) and D-STATCOM units. In the second stage, ratings of single-tuned PPFs and D-STATCOMs at the RESs are determined, considering non-linear loads in the network. The multi-objective function reduces power loss, improves the voltage stability index (VSI) and limits total harmonic distortion. Simulations using the IEEE 33-bus EDN compared the ARO results with those of previous studies. In the first scenario, ideally integrated D-STATCOMs, PVs and WTs reduced losses by 34.79%, 64.74% and 94.15%, respectively. VSI increases from 0.6965 to 0.7749, 0.8804 and 0.967. The optimal WT integration of the first scenario outperformed the PVs and D-STATCOMs. The second step optimizes the WTs and PQ devices for non-linear loads. WTs and D-STATCOMs reduce the maximum total harmonic distortion of the voltage waveform by 5.21% with non-linear loads to 3.23%, while WTs and PPFs reduce it to 4.39%. These scenarios demonstrate how WTs and D-STATCOMs can improve network performance and PQ. The computational efficiency of ARO is compared to that of the pathfinder algorithm, future search algorithm, butterfly optimization algorithm and coyote optimization algorithm. ARO speeds up convergence and improves solution quality and comprehension.
Experimental study on hybridization of a PV–TEG system for electrical performance enhancement using heat exchangers, energy, exergy and economic levelized cost of energy (LCOE) analysis
Authors: Qasim Mohammed A , Velkin Vladimir I , Shcheklein Sergey E 
Published: August 2023

Abstract
The concept of employing thermoelectric generators (TEGs) to recover energy from waste heat has gained popularity, with applications that range from milliwatt to kilowatt levels of output power. In this study, a hybrid photovoltaic panel and thermoelectric generator (HPVTEG) system consisting of an integrated heat exchanger, a commercial polycrystalline silicon photovoltaic (PV) panel and a commercial bismuth telluride TEG was proposed. Here, TE components can be used to cool PV modules, increasing their output power via the Seebeck effect. The main finding is that the hybrid system has a reduced average temperature of 16.01°C. The average power of the stand-alone PV panel is 28.06 W, but that of the HPVTEG system is 32.76 W, which is an increase of 4.7 W. The conversion efficiency and power of the hybrid system increased by 16.7% and 16.4%, respectively, compared with a stand-alone PV panel. The HPVTEG system achieved an average exergy efficiency of 12.79% compared with 10.98% for a stand-alone PV panel. According to the calculation results, the levelized cost of energy (LCOE) of the stand-alone PV panel can range from 0.06741 to 0.10251 US$/kWh depending on how many days it is in operation, while the LCOE of the HPVTEG system can range from 0.06681 to 0.10160 US$/kWh.
Risks, challenges and strategies of power systems against the background of carbon neutrality
Authors: Tan Qingbo , Li Xudong , Liang Yan 
Published: August 2023

Abstract
Building a new power system with new energy as the main body is an important means of achieving the goal of carbon neutrality. Compared with the traditional power system, the new power system has great changes and challenges in its safety mechanism and balance mechanism. Based on this, this paper focuses on the changes in the characteristics, functions and technologies of the new power system from the three sides of the source network and load. On this basis, the challenges faced by the high proportion of new-energy power systems are summarized from six aspects: reliability, stability, economy, data intelligence, flexibility and synergy. Finally, corresponding countermeasures, solutions and suggestions are put forward for the challenges of reliability, stability, economy, data intellectualization, flexibility and synergy, which provide ideas for the power guarantee of the new power system.
Application of Box–Behnken Design and Response Surface Methodology for Selecting the Optimum RP-HPLC Conditions for the Simultaneous Determination of Paracetamol and Diclofenac Sodium Along With Three Skeletal Muscle Relaxants in Three Different Pharmaceutical Dosage Forms
Authors: Elkady Ehab , Fouad Marwa , Mozayad Ayoub 
Published: August 2023

Abstract
An isocratic HPLC method has been developed and validated for estimating paracetamol and diclofenac sodium simultaneously with three skeletal muscle relaxants, namely, methocarbamol, tizanidine hydrochloride and chlorzoxazone in their pure standard mixtures and in different multi-component dosage forms in a single chromatographic run. HPLC separation was achieved on a C18 Inertsil ODS-3V 5 μm column (250 × 4.6 mm) using a mobile phase mixture containing acetonitrile and 25 mM phosphate buffer (pH 7.4 adjusted with NaOH) in the proportion of (39.7:60.3, v/v) pumped at 1.2 mL/min flow rate with UV detection at 220 nm. An experimental design was used by applying Plackett–Burman design for screening the most critical predictors affecting the chromatographic separation and Box–Behnken design for optimizing the selected predictors and creating the response surface between the selected predictors and the interested responses. ICH recommendations were applied for validating the proposed method with regard to linearity, precision, accuracy, selectivity, limits of detection and quantitation, and robustness. There are many applications for the optimized method that can be applied for routine estimation of the cited drugs in laboratories of quality control and pharmaceutical industries to save money and time and to reduce material waste and effort.
Species recognition and the divergences in the chemical and ultrasonic signals between two coexisting Rattus species
Authors: Wang Wei-Chao , Li Zhi-Ming , Chen Yi , Zhang, Jin-Hua , Zhang Jian-Xu , Zhang Yao-Hua 
Published: August 2023

Abstract
The ability to recognize and differentiate between conspecifics and heterospecifics as well as their signals is critical for the coexistence of closely related species. In the genus Rattus, species are morphologically similar and multiple species often coexist. Here, we investigated the interspecific recognition and signal differentiation of two sympatric rat species, the brown rat (Rattus norvegicus, RN) and the Asian house rat (Rattus tanezumi, RT). In a two-way choice test, both RN and RT females showed a preference for conspecific male rats to heterospecific ones. RT females showed a significant preference for accessible urine of males of same species to those of other species, but not for the inaccessible urine. On the other hand, there were significant differences in the structural characteristics of the ultrasonic vocalization emitted by males of these two rat species. Sodium dodecyl sulphate‒polyacrylamide gel electrophoresis (SDS‒PAGE) and isoelectric focusing electrophoresis unveiled that major urinary proteins (MUPs) in voided urine were more highly expressed in RN males versus RT males. The interspecific differences of urinary volatile compounds were also discussed. In conclusion, female rats had the ability to distinguish between males of either species.
Haemodynamic effects of inhaled nitric oxide in acute myocardial infarction complicated by right heart failure under ECPELLA support: case report
Authors: Fujita Kosuke , Ueno Masafumi , Yasuda Masakazu , Mizutani Kazuki , Miyoshi Tatsuya , Nakazawa Gaku 
Published: August 2023

Abstract

Background
Recently, mechanical support obtained with the combination of venoarterial extracorporeal membrane oxygenation (VA-ECMO) and an Impella device, together referred to as ECPELLA, has been shown to be effective for acute myocardial infarction with cardiogenic shock. However, methods for withdrawing VA-ECMO in acute myocardial infarction cases complicated by right ventricular dysfunction are yet to be established. Here, we report the effective use of inhaled nitric oxide during the weaning of VA-ECMO from the ECPELLA management of a patient with acute myocardial infarction with cardiogenic shock.

Case summary
An 81-year-old man with an acute extensive anterior wall myocardial infarction with cardiogenic shock was supported with ECPELLA to improve his haemodynamics. During ECPELLA, the Impella device could not maintain sufficient flow. Echocardiography revealed a small left ventricle and an enlarged right ventricle, indicating acute right heart failure. Inhaled nitric oxide was initiated to reduce right ventricle afterload, which decreased pulmonary artery pressure from 34/20 to 27/13 mmHg, improved right and left ventricle sizes, and stabilized the Impella support. Afterward, VA-ECMO could be withdrawn because the Impella alone was sufficient for haemodynamic support.

Discussion
Inhaled nitric oxide improved right ventricle performance in a patient with severe myocardial infarction with right heart failure supported by ECPELLA. Thus, we suggest that inhaled nitric oxide facilitates the weaning of VA-ECMO from patients with refractory right ventricular dysfunction who are supported by ECPELLA.
The risks of rejection vs. infection: Ramsay Hunt syndrome, Gradenigo syndrome, and varicella meningoencephalitis in a heart transplant patient
Authors: Benavente Kevin , Kozai Landon , Silangcruz Krixie , Banerjee Dipanjan 
Published: August 2023

Abstract

Background
Orthotopic heart transplant (OHT) recipients are at increased risk for varicella zoster reactivation, and severe complications may arise due to their immunosuppressive regimens. Managing immunosuppression in acute infection is difficult, and specific guideline recommendations or evidence from the literature are lacking. However, patient care must involve weighing the risk of transplant rejection with the consequences of worsening infection.

Case summary
An OHT patient with a history of multiple episodes of acute rejection, latent varicella zoster virus (VZV) infection, and recent completion of anti-viral prophylaxis presented with unilateral facial droop and pain, abducens nerve palsy, crusting facial rash, and ear swelling. Imaging revealed necrotizing otitis externa, with associated otitis media, and petrous apicitis concerning for Gradenigo syndrome. A VZV-positive viral panel confirmed our suspicion for Ramsay Hunt syndrome (RHS). The patient’s mentation continued to decline, and subsequent lumbar puncture also revealed VZV meningoencephalitis. The patient’s mycophenolate mofetil (MMF) was suspended, with continuation of tacrolimus, and initiation of intravenous acyclovir. The patient demonstrated gradual resolution of his infection, without developing any signs of acute rejection.

Discussion
Varicella zoster virus reactivation is common in OHT patients, particularly when viral prophylaxis is discontinued; however, cardiologists should be aware of the rarer manifestations that can manifest in these immunocompromised patients. This is the first documented case of simultaneous RHS, Gradenigo syndrome, and VZV meningoencephalitis in any patient, regardless of transplant status. We demonstrate that even in patients at very high risk of rejection, MMF can be safely discontinued and host immunity maintained with temporary tacrolimus monotherapy.
A case report of cardiac allograft vasculopathy complicated with coronary vasospasm: insights from near-infrared spectroscopy, intravascular ultrasound, and optical coherence tomography
Authors: Mukaida Takuto , Murai Kota , Mochizuki Hiroki , Noguchi Teruo 
Published: August 2023

Abstract

Background
Cardiac allograft vasculopathy (CAV) remains a major complication after heart transplantation. Although coronary vasospasm after heart transplantation has occasionally been reported, the association between CAV and coronary vasospasm remains unclear.

Case summary
A 68-year-old male with a history of heart transplantation 21 years ago presented with atypical angina. Coronary angiography demonstrated intermediate stenoses in the proximal and mid left anterior descending artery (LAD) and right posterolateral artery. Intracoronary acetylcholine provocation testing resulted in subtotal occlusion of the coronary arteries bilaterally, which was resolved by nitroglycerine administration, but the intermediate stenoses remained. The stenosis in the proximal LAD was physiologically significant based on fractional flow reserve. The patient was diagnosed with a developed CAV and concomitant coronary vasospasm and treated with percutaneous coronary intervention and nifedipine. Near-infrared spectroscopy and intravascular ultrasound showed a large isoechoic plaque with a low lipidic burden, suggesting a non-atherosclerotic plaque. Optical coherence tomography revealed a layered homogenous plaque, an intravascular imaging finding common in both CAV and coronary vasospasm. A drug-eluting stent dilated the stenosis, and follow-up angiography at 4 months showed no CAV progression.

Discussion
This case highlights the potential association between CAV and coronary vasospasm. Intravascular imaging detected similarities in plaque morphology between CAV and coronary vasospasm, suggesting that coronary vasospasm might contribute to the development of CAV. Although coronary vasospasm may be underdiagnosed in heart transplant recipients due to the lack of symptoms involving the denervated heart, this case showed that appropriate provocation testing may be beneficial for evaluating the cause of CAV.
International Law Must Respond to the Reality of Future Generations: A Reply to Stephen Humphreys
Authors: Lawrence Peter 
Published: August 2023

Abstract
Stephen Humphreys in his article ‘Against Future Generations’ in this journal argues against intergenerational framings in the climate context, claiming that such framings work against future generations by carrying forward today’s structural inequalities into the future. He contends that those using such framings tend to subordinate global intra-generational equity to local intergenerational equity, glossing over very significant differences in power and wealth amongst those impacted by climate change. This response to Humphreys’ article argues that Humphreys has set up a false dichotomy: it is not only developed countries that care about future generations – developing countries are concerned about addressing poverty now and their own future generations. Humphreys’ claim that climate litigation has and should limit itself to harms to persons alive now is also unconvincing. Most climate litigation involving children or young people to date has included claims brought by them both in relation to their own interests (now and in the future) and on behalf of future generations. The response points to cases where, contrary to Humphreys’ position – harms extending to future generations have made a substantive difference in legal outcomes.
Different Interpretations of “Honor Your Parents”: Implications for Obligation of Parental Caregiving
Authors: Esiaka Darlingtina K , Luth Elizabeth 
Published: August 2023

Abstract

Objectives
Many religious and cultural settings embrace the principle to “honor your parents.” However, how individuals understand and enact this mandate varies by cultural context and community. The different understanding of “honor your parents” draws attention to motivations for parental caregiving across cultural contexts. This study investigates how individuals in 3 different cultural settings conceptualize “honoring your parents” and how these conceptualizations affect their perceptions of obligations to care for an older parent.

Methods
Semistructured interviews with 153 individuals in the United States, Ghana, and Nigeria explored the concept of “honor your parents,” how it is understood, and its relationship to the perceived obligation to care for one’s parents. A content analysis was applied to all transcripts and analyzed for discussion.

Results
Among individuals in the United States, “honor your parents” is less likely to be conceived as providing material and instrumental care to a parent, and more in terms of emotional care. In contrast, individuals in Nigeria and Ghana closely associated “honor your parents” with providing material and instrumental care to a parent.

Discussion
Understanding how different conceptions of “honor your parents” translate to expectations for and modes of parental caregiving can illuminate how caregiving needs can be met for the aging populations of the United States, Ghana, and Nigeria.
Genome resequencing reveals independent domestication and breeding improvement of naked oat
Authors: Nan Jinsheng , Ling Yu , An Jianghong , Wang Ting , Chai Mingna , Fu Jun , Wang Gaochao , Yang Cai , Yang Yan , Han Bing 
Published: August 2023

Abstract
As an important cereal crop, common oat, has attracted more and more attention due to its healthy nutritional components and bioactive compounds. Here, high-depth resequencing of 115 oat accessions and closely related hexaploid species worldwide was performed. Based on genetic diversity and linkage disequilibrium analysis, it was found that hulled oat (Avena sativa) experienced a more severe bottleneck than naked oat (Avena sativa var. nuda). Combined with the divergence time of ∼51,200 years ago, the previous speculation that naked oat was a variant of hulled oat was rejected. It was found that the common segments that hulled oat introgressed to naked oat cultivars contained 444 genes, mainly enriched in photosynthetic efficiency-related pathways. Selective sweeps during environmental adaptation and breeding improvement were identified in the naked oat genome. Candidate genes associated with smut resistance and the days to maturity phenotype were also identified. Our study provides genomic resources and new insights into naked oat domestication and breeding.
A Phase 2 Extension Study Evaluating the Immunogenicity, Safety, and Tolerability of 3 or 4 Doses of a Clostridioides difficile Vaccine in Healthy US Adults Aged 65 to 85 Years
Authors: Remich Shon , Kitchin Nicholas , Peterson James , Li Ping , Pride Michael W , Brock Linda , Anderson Annaliesa S , Gruber William C , Jansen Kathrin U , Lockhart Stephen P , Webber Chris 
Published: August 2023

Abstract

Background
This phase 2 extension explored the long-term antibody persistence of an investigational Clostridioides difficile vaccine and the safety, tolerability, and immunogenicity of dose 4 approximately 12 months post–dose 3.

Methods
One year post–dose 3, healthy US 65- to 85-year-olds (N = 300) were randomized to dose 4 of vaccine at previously received antigen levels (100 or 200 μg) or placebo. Assessments included safety and percentages of participants achieving neutralizing antibody titers above prespecified thresholds (≥219 and ≥2586 neutralization units/mL for toxins A and B, respectively).

Results
In participants previously given three 200-µg doses and placebo in the extension, toxin A and B neutralizing antibodies were above prevaccination levels 48 months post–dose 3 (36 months after placebo); 24.0% and 26.0% had toxin A and B antibodies at or above prespecified thresholds, respectively. Neutralizing antibodies increased post–dose 4 (12 months post–dose 3) and persisted to 36 months post–dose 4. Thirty days post–dose 4, all participants had toxin A and 86.5% to 100% had toxin B titers at or above prespecified thresholds. Local reactions were more frequent in vaccine recipients. Systemic and adverse event frequencies were similar across groups.

Conclusions
C difficile vaccine immune responses persisted 48 months post–dose 3. Dose 4 was immunogenic and well tolerated, supporting continued development.
Clinical Trials Registration. ClinicalTrials.gov NCT02561195.
Detection of the Adulteration of Dendrobium Huoshanense with Dendrobium Henanense by UV-Vis-Shortwave Near-Infrared Diffuse Reflectance Spectroscopy Combined with Chemometrics
Authors: Hao Jing-Wen , Chen Nai-Dong , Liu Xiao-Quan , Li Qiang , Xu Hui-Min , Yang Wei-Han , Qin Chao-Feng , Bu Ya-Qing 
Published: August 2023

Abstract

Background
Dendrobium huoshanense (DHS) is a classic traditional Chinese medicine (TCM) with distinctive medicinal benefits and great economic worth; nevertheless, because of similar tastes and looks, it is simple to adulterate with less expensive substitutes (such as Dendrobium henanense [DHN]).

Objective
This work aimed to develop a reliable tool to detect and quantify the adulteration of DHS with DHN by using UV-Vis-shortwave near-infrared diffuse reflectance spectroscopy (UV-Vis-SWNIR DRS) combined with chemometrics.

Methods
Adulterated samples prepared in varying concentrations (0–100%, w/w) were analyzed with UV-Vis-SWNIR DRS methods. Partial least-square-discriminant analysis (PLS-DA) and partial least-squares (PLS) regression techniques were used for the differentiation of adulterated DHN from pure DHS and the prediction of adulteration levels.

Results
The PLS-DA classification models successfully differentiated adulterated and nonadulterated DHS with an over 100% correct classification rate. UV-Vis-SWNIR DRS data were also successfully used to predict adulteration levels with a high coefficient of determination for calibration (0.9924) and prediction (0.9906) models and low error values for calibration (3.863%) and prediction (5.067%).

Conclusion
UV-Vis-SWNIR DRS, as a fast and environmentally friendly tool, has great potential for both the identification and quantification of adulteration practices involving herbal medicines and foods.

Highlights
UV-Vis-SWNIR DRS combined with chemometrics can be applied to identify and quantify the adulteration of herbal medicines and foods.
First record of leucism in a primary burrowing crayfish:Distocambarus crockeriHobbs & Carlson, 1983 (Decapoda: Astacidea: Cambaridae) from South Carolina, USA
Authors: Stubbs Megan B , Wells Hogan D , Barnett Zanethia C , Kendrick Michael R , Loughman Zachary J , Graham Zackary A 
Published: August 2023

AbstractThe piedmont prairie burrowing crayfish, Distocambarus crockeri Hobbs & Carlson, 1983, is a primary burrowing crayfish endemic to South Carolina, USA. The species is the most widely distributed and studied of the five species of Distocambarus Hobbs, 1981. Surveys have clarified the species distribution and habitat, but, like other burrowing crayfishes, our understanding of its ecology is lacking. We report the discovery of two leucistic specimens of D. crockeri collected in an ephemeral pool in a roadside ditch on 14 March 2022 in Edgefield County, South Carolina. To the best of our knowledge, our discovery represents the first documented case of leucism in a primary burrowing crayfish. We discuss the significance of this observation in relation to other recorded observations of color anomalies throughout crayfishes as well as potential environmental causes of leucism.