bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital outpatient health solutions as a vehicle to improve healthcare sustainability—a United Kingdom focused policy and practice perspective
Authors: Brown Matthew R. D. , Knight Matthew , Peters Christopher J. , Maleki Simin , Motavalli Ali , Nedjat-Shokouhi Bahman 
Published: September 2023

IntroductionIn the midst of a global climate emergency and with health care systems across the world facing extreme pressure, interest in digital approaches as a potential part-solution to these challenges has increased rapidly. The evidence base to support the role that digitalization can play in moving towards more sustainable models of healthcare is growing, as is the awareness of this key area of healthcare reform amongst policy makers, clinicians and the public.Method and ResultsIn this policy and practice review we explore four domains of healthcare sustainability-environmental, economic, and patient and clinician, delineating the potential impact that digitally enabled healthcare can have on each area. Real-world examples are provided to illustrate the impact individual digital interventions can have on each pillar of sustainability and demonstrate the scale of the potential benefits which can be achieved.DiscussionDigitally enabled healthcare solutions present an approach which offer numerous benefits, including environmental sustainability, economic benefits, and improved patient experience. There are also potential drawbacks such as the risk of digital exclusion and the need for integration with existing technology platforms. Overall, it is essential to strike a balance between the benefits and potential drawbacks of digital healthcare solutions to ensure that they are equitable, effective, and sustainable.
A systematic review and meta-analysis of the diagnostic accuracy of metagenomic next-generation sequencing for diagnosing tuberculous meningitis
Authors: Xiang Zheng-Bing , Leng Er-Ling , Cao Wen-Feng , Liu Shi-Min , Zhou Yong-Liang , Luo Chao-Qun , Hu Fan , Wen An 
Published: September 2023

ObjectiveThe utility of metagenomic next-generation sequencing (mNGS) in the diagnosis of tuberculous meningitis (TBM) remains uncertain. We performed a meta-analysis to comprehensively evaluate its diagnostic accuracy for the early diagnosis of TBM.MethodsEnglish (PubMed, Medline, Web of Science, Cochrane Library, and Embase) and Chinese (CNKI, Wanfang, and CBM) databases were searched for relevant studies assessing the diagnostic accuracy of mNGS for TBM. Review Manager was used to evaluate the quality of the included studies, and Stata was used to perform the statistical analysis.ResultsOf 495 relevant articles retrieved, eight studies involving 693 participants (348 with and 345 without TBM) met the inclusion criteria and were included in the meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the summary receiver-operating characteristic curve of mNGS for diagnosing TBM were 62% (95% confidence interval [CI]: 0.46–0.76), 99% (95% CI: 0.94–1.00), 139.08 (95% CI: 8.54–2266), 0.38 (95% CI: 0.25–0.58), 364.89 (95% CI: 18.39–7239), and 0.97 (95% CI: 0.95–0.98), respectively.ConclusionsmNGS showed good specificity but moderate sensitivity; therefore, a more sensitive test should be developed to assist in the diagnosis of TBM.
Persistence is key: unresolved immune dysfunction is lethal in both COVID-19 and non-COVID-19 sepsis
Authors: An Andy Y. , Baghela Arjun , Zhang Peter , Falsafi Reza , Lee Amy H. , Trahtemberg Uriel , Baker Andrew J. , Santos Claudia C. dos , Hancock Robert E. W. 
Published: September 2023

IntroductionSevere COVID-19 and non-COVID-19 pulmonary sepsis share pathophysiological, immunological, and clinical features, suggesting that severe COVID-19 is a form of viral sepsis. Our objective was to identify shared gene expression trajectories strongly associated with eventual mortality between severe COVID-19 patients and contemporaneous non-COVID-19 sepsis patients in the intensive care unit (ICU) for potential therapeutic implications.MethodsWhole blood was drawn from 20 COVID-19 patients and 22 non-COVID-19 adult sepsis patients at two timepoints: ICU admission and approximately a week later. RNA-Seq was performed on whole blood to identify differentially expressed genes and significantly enriched pathways. Using systems biology methods, drug candidates targeting key genes in the pathophysiology of COVID-19 and sepsis were identified.ResultsWhen compared to survivors, non-survivors (irrespective of COVID-19 status) had 3.6-fold more “persistent” genes (genes that stayed up/downregulated at both timepoints) (4,289 vs. 1,186 genes); these included persistently downregulated genes in T-cell signaling and persistently upregulated genes in select innate immune and metabolic pathways, indicating unresolved immune dysfunction in non-survivors, while resolution of these processes occurred in survivors. These findings of persistence were further confirmed using two publicly available datasets of COVID-19 and sepsis patients. Systems biology methods identified multiple immunomodulatory drug candidates that could target this persistent immune dysfunction, which could be repurposed for possible therapeutic use in both COVID-19 and sepsis.DiscussionTranscriptional evidence of persistent immune dysfunction was associated with 28-day mortality in both COVID-19 and non-COVID-19 septic patients. These findings highlight the opportunity for mitigating common mechanisms of immune dysfunction with immunomodulatory therapies for both diseases.
The preferred growth orientation of Ti thin film on MgO(100) substrate
Authors: Yang Jun , Baco Saturi , Jin Yongzhong , Shu Yi , Fang Yong , Moh Pak Yan 
Published: September 2023

Understanding the preferred growth orientation of metal films is of great significance for optimizing film properties and preparing films with special structures. However, early works mainly focused on the preferred growth orientations of FCC and BCC metal films, the preferred growth orientation of HCP metal films and its formation mechanism are unclear. In this work, Ti film was deposited on MgO(100) substrate by magnetron sputtering at 523 K. The preferred growth orientation of Ti film and its formation mechanism were studied by experiment and first-principles calculation. XRD results found the preferred growth orientations of Ti film on MgO(100) substrate were Ti(001), Ti(100), and Ti(101), with Ti(001) being the most favored. First-principles calculation results showed the preferred growth orientation of the Ti film on the MgO(100) substrate was determined by a combination of interface separation work and lattice strain.
Apulian infectious diseases network: survey on the prevalence of delta infection among chronic HBV carriers in Apulia
Authors: Fasano Massimo , Milella Michele , Carbonara Sergio , Tundo Paolo , Minniti Salvatore , Buccoliero Giovanni , Maci Anna Maria , Lo Caputo Sergio , Santantonio Teresa Antonia 
Published: September 2023

BackgroundThe current prevalence and clinical burden of Hepatitis Delta Virus (HDV) infection in Apulia are unknown. This study aimed to define the current epidemiological scenario of delta infection and to detect difficulties in the diagnosis and clinical management of HDV patients in Apulia.MethodsFrom May to September 2022, a fact-finding survey was conducted at eight Infectious Diseases Units of the Apulian region; each Unit was asked to complete a questionnaire on screening and diagnosis of HDV infection and demographic, virological, and clinical characteristics of HDV patients.ResultsA total of 1,461 HBsAg-positive subjects were followed up on an outpatient basis. Screening for HDV ranged from 30 to 90% of HBsAg + carriers in a single center. Overall, 952 HBsAg ± subjects (65%) were tested for HDV, and 80/952 (8.4%) were anti-HDV positive. Serum HDV RNA was detected only in 15/80 (19%) anti-HDV-positive subjects, and 12/15 patients (80%) were viremic. Sixty-five anti-HDV-positive subjects (81%) were from Italy; risk factors for HDV acquisition included the presence of HDV infection in the family (29/80 = 36%), drug addiction (12/80 = 15%), and co-infection with HCV or HIV (7/80 = 9%). Liver cirrhosis and hepatocellular carcinoma were diagnosed in 41 (51%) and 4 (5%) patients, respectively. Fifty-seven patients (71%) received nucleos(t)ide analog treatment.ConclusionsThe results of this survey show that HDV screening is variable and insufficient, thus real prevalence data on delta infection are lacking in Apulia. Moreover, the HDV RNA test is not available in most laboratories and is not provided by the national health system. These results underline the need for an organizational model to optimize the management of HDV patients throughout the Apulian region.
Effect of Continuous Ingestion of Bifidobacteria and Dietary Fiber on Improvement in Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Azuma Naoki , Mawatari Takashi , Saito Yasuo , Tsukamoto Masashi , Sampei Masatoshi , Iwama Yoshitaka 
Published: September 2023

Bifidobacterium animalis subsp. lactis GCL2505 has been shown to have some positive effects on health, including improved defecation frequency and reduced visceral fat. These effects are thought to be due to GCL2505′s unique ability to reach the intestine in a viable form and proliferate after a single intake. This leads to an increased number of intestinal bifidobacteria. This randomized, double-blind, placebo-controlled, parallel-group study was conducted to confirm that intake of GCL2505 and inulin (a prebiotic) improve cognitive function (n = 80). Participants consumed test drinks containing 1 × 1010 colony-forming units of GCL2505 per 100 g and 2.0 g of inulin per 100 g for 12 weeks. The change in cognitive function assessment scores was set as the primary endpoint. There were significant improvements in scores in the neurocognitive index domain, which is an assessment of overall cognitive function, in addition to overall attention, cognitive flexibility, and executive function domains. The intervention significantly increased the number of fecal bifidobacteria and affected the levels of several inflammatory markers. These results suggest that intake of GCL2505 and inulin improves cognitive function by improving the intestinal environment and alleviating inflammation.
Anterior cervical discectomy and fusion in the era of motion preserving surgery
Authors: S. Arun , V. Abhishek , Goswami Prakash , V. Sanu , L.S. Jyothish , Kumar B.S . Sunil , Kumar K.L. Suresh , Kumar P. Anil , P. Mathew Oommen 
Published: September 2023

Background. Anterior cervical discectomy and fusion is accepted as the standard surgical treatment of cervical spondylotic myelopathy. Cervical disc arthroplasty has gained widespread acceptance as an alternate choice for ACDF. We intend to present the clinical and radiologic outcomes of patients who underwent ACDF in our department.
Methods. Designed as a retrospective study, the primary objective was to assess the nonunion in patients undergoing ACDF and Anterior cervical Corpectomy and fusion. The article discusses the outcome for the discectomy group. All patients who underwent ACDF for CSM from January 2014 to December 2018 were included. Patients who underwent posterior fusion in addition to anterior approach, revision surgery and congenital anomalies of the spine were excluded. Of the 230 eligible patients,46 subjects were part of the study. They underwent neurologic and radiographic examination and their past records were examined. Neurologic outcome was assessed using Nurick grade and mJOA score. Dysphagia was assessed using the Bazaz score. Neck radiographs were analysed for fusion, Adjacent segment Disease, subsidence, cervical and segmental lordosis.
Results. The overall response rate was 25.65%. The mean follows up duration was 4 years. The mean age of the population was 47.1 years. The most common operating level was C5/6. The neurologic status of patients improved from the baseline. There was mild transient dysphagia in 5(10.9%) patients. The overall rate of fusion was 91.3%. Subsidence was seen in 10.9%. Degenerative changes were noted in postop x rays of 67.4% of patients. There was no mortality.
Conclusion. ACDF achieves thorough decompression thereby resulting in neurologic improvement. It produces effective and sustained neurologic improvement. Preoperative adjacent segment degenerative changes were significantly associated with the development of ASD during follow up. This is can due to the progression of the disease. Though the procedure improves the lordosis, it tends to decrease with follow up.
Full endoscopic lumbar decompression of spinal stenosis through uniportal approach
Authors: Cem Ovalioglu Talat , Aydin Salih 
Published: September 2023

Introduction: To investigate the certain advantages of full endoscopic lumbar decompression (FELD) surgery over conservative techniques in lumbar spinal stenosis (LSS). Minimal invasive techniques have been introduced recently to treat lumbar spinal stenosis and gained popularity over conservative techniques because of the minimal tissue damage along with the satisfactory postoperative outcome. In our study, the FELD technique using a uniportal approach is described and investigated in accordance with the preliminary clinical results of patients who had degenerative spinal stenosis.
Methods: 55 patients who underwent FELD were retrospectively reviewed. General demographics and parameters including operation time, length of hospital stay, mean time to return to work, complications were recorded. Clinical outcomes were evaluated using the visual analogue scale (VAS) for low back and leg pain, Oswestry Disability Index (ODI) for functional assessment.
Results: The mean follow-up time was 36 months. There was no measurable intraoperative blood loss. The mean operating time was 97,4 minutes. The length of hospital stay after the operation was 27 hours on average. The difference between preoperative and postoperative VAS scores was statistically significant (p<0.001). No surgery-related complication was noted.
Conclusions: Amongst other standard techniques, FELD has the technical advantages of less paraspinal muscle dissection, less tissue trauma, less risk of spinal instability, minimal blood loss, quicker postoperative recovery and shorter length of hospital stay.
Study of association of serum vitamin D and serum calcium with spontaneous aneurysmal subarachnoid haemorrhage in a tertiary care centre
Authors: Singh Kuldeep , Pandey Sharad , Kumar Pankaj , Gupta L.N. , Mehto Amit , Jha Ravi Prakesh 
Published: September 2023

Background: Aneurysmal subarachnoid haemorrhage (aSAH) is a disease associated with high mortality and morbidity. Recent studies have postulated a correlation between Vitamin D deficiency and aSAH, however, the mechanism of which remains obscure. Vitamin D and Calcium in patients withaSAH has not been formally investigated. Therefore, the aim of this study was to evaluate the incidence of hypovitaminosis D and hypocalcemia in patients with aSAH.
Methods: An observational study was conducted at the Department of Neurosurgery at tertiary care centre, New Delhi, India. 40 patients with spontaneous aneurysmal SAH were enrolled during the period January 2019 to 15th April 2020. The standard protocol of care was given to all patients included in the study. Laboratory investigations including Vitamin D and Calcium levels; Clinical examination and grading were done for each patient. The data thus collected was used to see the clinic-demographic profile of patients of aSAH with an emphasis on Vitamin D and Calcium levels.
Results: The study reported mean vitamin D level of 17.4 ± 7 ng/ml; mean calcium level of 8.3 ± 0.9 mg/dl amongst the study participants. Out of 40 patients, 8 patients (20%) were severely deficient, 24 patients (60%) were mild to moderate deficient and 8 patients (20%) were having normal vitamin D levels. 50% of the patients (n=20) were hypocalcaemic and 50% were normocalcaemic.
Conclusion: A higher incidence of vitamin D deficiency was observed in our study along with an equal incidence of hypocalcemia vs normocalcemia. Further studies with a comparison group and a bigger sample size are needed to validate this evidence.
La Massorah. [Situation des recherches massorétiques entreprises dans le cadre de la Section biblique et massorétique de l'Institut de Recherche et d'Histoire des Textes, de 1961 à 1972]
Authors: Weil Gérard Emmanuel 
Published: September 2023

L'auteur, à partir de manuscrits et de fragments de manuscrits dont il poursuit l'édition avec son groupe de recherche, tente de faire une synthèse de l'histoire de la Massorah, dont il voit l'origine dans la rédaction du Targum canonique babylonien.
A l'origine de la Massorah babylonienne l'auteur assigne les débuts de la rédaction du Talmud babylonien du Pentateuque ; point de jonction avec la Massorah de Tibériade, il n'est plus seulement classique et babylonien, mais il est devenu le Targum canonique du Pentateuque, auquel on a imposé par erreur le nom hébraïsé d'Akylas sous la forme d'Onkelos. A Vorigine de la Massorah babylonienne l'auteur assigne les débuts de la rédaction du Talmud babylonien du Pentateuque ; point de jonction avec la Massorah de Tibériade, il n'est plus seulement classique et babylonien, mais il est devenu le Targum canonique du Pentateuque, auquel on a imposé par erreur le nom hébraïsé d'Akylas sous la forme d'Onkelos.
CHALLENGES OF USING L- AND S-BANDS FOR THE DIRECTTO-CELLULAR HYBRID SATELLITE 5GA/6G SYSTEMS
Authors: Пастух А.С. , Калугина Д.И. , Девяткин Е.Е. , Иванкович М.В. 
Published: September 2023

Проведено исследование влияния помех, вызванных многоспутниковыми гибридными спутниковыми сетями (ГСС) 5GA/6G в L- и S-диапазонах, которые обозначены 3GPP как полосы n255 и n256 для неназемных сетей NTN (non-terrestrial networks). Описана методология исследования и этапы моделирования. Представлены расчеты и выводы о влиянии гибридных спутниковых систем в L- и S-диапазонах на линии связи абонентских терминалов (АТ) и земных станций (ЗС) систем Inmarsat, Lyra и Omnispace. На основании проведенных исследований сделан вывод о проблематичности использования диапазонов n255 и n256 для построения гибридных спутниковых сетей связи.
This paper evaluates interference of 5GA/6G NTN satellite systems in L- and S-bands, which are marked by 3GPP as n255 and n256 bands for NTN networks. The research methodology and simulation stages are described. Calculations and conclusions about the influence of hybrid satellite systems in the L- and S-bands on the communication lines of user terminals and earth stations of the Inmarsat, Lyra and Omnispace systems are presented. Based on the studies carried out, a conclusion was made about the challenges of using n255 and n256 bands for NTN satellite systems.
MODELING OF HOMOGENEOUS LADDER ELECTRICAL CIRCUITS IN TELECOMMUNICATIONS BY THE RECURRENT METHOD
Authors: Ясинский С.А. 
Published: September 2023

В статье произведен анализ математических моделей для моделирования резистивных однородных линейных электрических цепей рекуррентным методом с последующим его совершенствованием с учетом ранее не исследованных возможных разновидностей вариантов построения линейных однородных структур, состоящих из резистивных, емкостных и индуктивных элементов.
The article analyzes mathematical models for modeling resistive homogeneous linear electrical circuits by the recurrent method with its subsequent improvement taking into account previously unexplored possible varieties of options for constructing linear homogeneous structures consisting of resistive, capacitive and inductive elements.
Pengaruh Pemberian Jus Umbi Bit terhadap Kadar Hemoglobin Ibu Hamil Trimester III
Authors: Fadillah Willya Rizky , Widowati Retno , Dahlan Febry Mutiariami 
Published: September 2023

WHO data (2020), it estimated that worldwide around 32 million pregnant women have anemia. In Indonesia, the incidence of anemia in pregnant women increased in 2018 by 48.8% when compared to 2013, which was 37.1%. Garut Regency in 2019 the prevalence of pregnant women with anemia was 6669 people. Karangpawitan Health Center in 2021, out of 834 pregnant women, 31.5% experienced anemia in the first trimester and as many as 168 pregnant women in third trimester (20.1%). Non-pharmacologically the treatment and prevention of anemia is by consuming green vegetables, nuts, chicken liver, beet tubers, red guava fruit and others. The content of beet tubers in the list of food ingredients includes 108 mg of folic acid, 27.0 mg of calcium, 43.0 mg of phosphorus, 43 mg of vitamin C, 23 mg of magnesium, 9.6 mg of carbohydrates, 1.0 mg of iron (Ministry of Health RI, 2016). Folic acid is very good to help the formation of the baby's brain and overcome the problem of anemia. The purpose of the study was to determine the effect of beetroot juice on hemoglobin levels of pregnant women in the third trimester at Karangpawitan Public Health Center, Garut Regency. The methodology of this research uses Pre test - Post test with control group design. The population in the study were all pregnant women in the third trimester as many as 129 people The samples in this study were TM III pregnant women who experienced mild anemia using purposive sampling as many as 30 people who were divided into 2 groups, namely 15 people in the experimental group and 15 people in the control group. The instruments used are observation sheets and technical instructions for beetroot juice. Data analysis used Paired T-test and Independent Samples Test. The results of the study the average hemoglobin level in the experimental group before being given beet juice was 9.160 and after beet juice was 10.807, while in the control group before the intervention was 8.933 and after the intervention was 9.813. The bivariate results showed a p-value of 0.000 <0.05. The conclusion is that there is an effect of giving beetroot juice + Fe tablets on hemoglobin levels of pregnant women in the third trimester at Karangpawitan Health Center, Garut Regency In 2023. With this study, consumption of beet root juice can be an alternative in increasing hemoglobin levels in pregnant women.
POLA ASUH ORANG TUA DALAM PEMBENTUKAN KEMANDIRIAN ANAK
Authors: Adminpintarharati  
Published: September 2023

Sikap mandiri merupakan bagian dari perilaku anak yang harus dikembangkan sejak dini sebagai pondasi keterampilan kehidupan kelak.Usia dini merupakan waktu yang tepat untuk mengembangkan segala aspek perkembangan karena anak mengalami proses tumbuh dan berkembang secara pesat. Keluarga merupakan lingkungan sosial pertama yang ditemui individu sejak mereka lahir ke dunia. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pengaruh orang tua dalam membentuk kemandirian anak di kelas 2 & 3 SD EFATA di Baloi Permai, Batam . Metode yang digunakan dalam penelitian ini adalah kualitatif deskriptif dengan teknik pengumpulan data menggunakan wawancara, observasi, dan dokumentasi, setelah itu diproses melalui triangulasi data. Populasi penelitian ini adalah orang tua siswa dari kelas 2 & 3 SD yang ada di sekolah EFATA. Berdasarkan hasil penelitian ini menunjukkan bahwa pengaruh setiap orang tua yang menjalankan pola asuh yang sesuai akan cenderung dengan mudah membentuk kemandirian anak mereka. Kesimpulan dari penelitian ini adalah dari empat jenis pola asuh hanya satu yang signifikan yaitu pola asuh otoratif ataupun demokratis.

Kata Kunci: Pola asuh, sikap mandiri dan, siswa.