bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting response of immunotherapy and targeted therapy and prognosis characteristics for renal clear cell carcinoma based on m1A methylation regulators
Authors: Li Lei , Tan Hongwei , Zhou Jiexue , Hu Fengming 
Published: August 2023

AbstractIn recent years, RNA methylation modification has been found to be related to a variety of tumor mechanisms, such as rectal cancer. Clear cell renal cell carcinoma (ccRCC) is most common in renal cell carcinoma. In this study, we get the RNA profiles of ccRCC patients from ArrayExpress and TCGA databases. The prognosis model of ccRCC was developed by the least absolute shrinkage and selection operator (LASSO) regression analysis, and the samples were stratified into low–high risk groups. In addition, our prognostic model was validated through the receiver operating characteristic curve (ROC). “pRRophetic” package screened five potential small molecule drugs. Protein interaction networks explore tumor driving factors and drug targeting factors. Finally, polymerase chain reaction (PCR) was used to verify the expression of the model in the ccRCC cell line. The mRNA matrix in ArrayExpress and TCGA databases was used to establish a prognostic model for ccRCC through LASSO regression analysis. Kaplan Meier analysis showed that the overall survival rate (OS) of the high-risk group was poor. ROC verifies the reliability of our model. Functional enrichment analysis showed that there was a obviously difference in immune status between the high-low risk groups. “pRRophetic” package screened five potential small molecule drugs (A.443654, A.770041, ABT.888, AG.014699, AMG.706). Protein interaction network shows that epidermal growth factor receptor [EGRF] and estrogen receptor 1 [ESR1] are tumor drivers and drug targeting factors. To further analyze the differential expression and pathway correlation of the prognosis risk model species. Finally, polymerase chain reaction (PCR) showed the expression of YTHN6-Methyladenosine RNA Binding Protein 1[YTHDF1], TRNA Methyltransferase 61B [TRMT61B], TRNA Methyltransferase 10C [TRMT10C] and AlkB Homolog 1[ALKBH1] in ccRCC cell lines. To sum up, the prognosis risk model we created not only has good predictive value, but also can provide guidance for accurately predicting the prognosis of ccRCC.
Polymeric nature of tandemly repeated genes enhances assembly of constitutive heterochromatin in fission yeast
Authors: Yamamoto Tetsuya , Asanuma Takahiro , Murakami Yota 
Published: August 2023

AbstractMotivated by our recent experiments that demonstrate that the tandemly repeated genes become heterochromatin, here we show a theory of heterochromatin assembly by taking into account the connectivity of these genes along the chromatin in the kinetic equations of small RNA production and histone methylation, which are the key biochemical reactions involved in the heterochromatin assembly. Our theory predicts that the polymeric nature of the tandemly repeated genes ensures the steady production of small RNAs because of the stable binding of nascent RNAs produced from the genes to RDRC/Dicers at the surface of nuclear membrane. This theory also predicts that the compaction of the tandemly repeated genes suppresses the production of small RNAs, consistent with our recent experiments. This theory can be extended to the small RNA-dependent gene silencing in higher organisms.
Chemical footprints of giant planet formation
Authors: Jiang Haochang , Wang Yu , Ormel Chris W. , Krijt Sebastiaan , Dong Ruobing 
Published: August 2023

Context. Protoplanetary disks, the birthplaces of planets, commonly feature bright rings and dark gaps in both continuum and line emission maps. Accreting planets interact with the disk, not only through gravity, but also by changing the local irradiation and elemental abundances, which are essential ingredients for disk chemistry.
Aims. We propose that giant planet accretion can leave chemical footprints in the gas local to the planet, which potentially leads to the spatial coincidence of molecular emissions with the planet in the ALMA observations.
Methods. Through 2D multi-fluid hydrodynamical simulations in Athena++ with built-in sublimation, we simulated the process of an accreting planet locally heating up its vicinity, opening a gas gap in the disk, and creating the conditions for C-photochemistry.
Results. An accreting planet located outside the methane snowline can render the surrounding gas hot enough to sublimate the C-rich organics off pebbles before they are accreted by the planet. This locally elevates the disk gas-phase C/O ratio, providing a potential explanation for the C2H line-emission rings observed with ALMA. In particular, our findings provide an explanation for the MWC 480 disk, where previous work identified a statistically significant spatial coincidence of line-emission rings inside a continuum gap.
Conclusions. Our findings present a novel view of linking the gas accretion of giant planets and their natal disks through the chemistry signals. This model demonstrates that giant planets can actively shape their forming chemical environment, moving beyond the traditional understanding of the direct mapping of primordial disk chemistry onto planets.
An inner warp discovered in the disk around HD 110058 using VLT/SPHERE and HST/STIS
Authors: Stasevic S. , Milli J. , Mazoyer J. , Lagrange A.-M. , Bonnefoy M. , Faramaz-Gorka V. , Ménard F. , Boccaletti A. , Choquet E. , Shuai L. , Olofsson J. , Chomez A. , Ren B. , Rubini P. , Desgrange C. , Gratton R. , Chauvin G. , Vigan A. , Matthews E. 
Published: August 2023

Context. An edge-on debris disk was detected in 2015 around the young, nearby A0V star HD 110058. The disk showed features resembling those seen in the disk of β Pictoris that could indicate the presence of a perturbing planetary-mass companion in the system.
Aims. We investigated new and archival scattered light images of the disk in order to characterise its morphology and spectrum. In particular, we analysed the disk’s warp to constrain the properties of possible planetary perturbers.
Methods. Using data from two VLT/SPHERE observations taken with the Integral Field Spectrograph (IFS) and near InfraRed Dual-band Imager and Spectrograph (IRDIS), we obtained high-contrast images of the edge-on disk. Additionally, we used archival data from HST/STIS with a poorer inner-working angle but a higher sensitivity to detect the outer parts of the disk. We measured the morphology of the disk by analysing vertical profiles along the length of the disk to extract the centroid spine position and vertical height. We extracted the surface brightness and reflectance spectrum of the disk.
Results. We detect the disk between 20 au (with SPHERE) and 150 au (with STIS), at a position angle of 159.6° ± 0.6°. Analysis of the spine shows an asymmetry between the two sides of the disk, with a 3.4° ± 0.9° warp between ~20au and 60 au. The disk is marginally vertically resolved in scattered light, with a vertical aspect ratio of 9.3 ± 0.7% at 45 au. The extracted reflectance spectrum is featureless, flat between 0.95 µm and 1.1 µm, and red from 1.1 µm to 1.65 µm. The outer parts of the disk are also asymmetric with a tilt between the two sides compatible with a disk made of forward-scattering particles and seen not perfectly edge-on, suggesting an inclination of <84°.
Conclusions. The presence of an undetected planetary-mass companion on an inclined orbit with respect to the disk could explain the warp. The misalignment of the inner parts of the disk with respect to the outer disk suggests a warp that has not yet propagated to the outer parts of the disk, favouring the scenario of an inner perturber as the origin of the warp.
Implications of Ozempic and Other GLP-1 Receptor Agonists for Facial Plastic Surgeons
Authors: Humphrey Clinton D. , Lawrence Anna C. 
Published: August 2023

AbstractObesity is a growing global health concern. Glucagon-like peptide-1 (GLP-1) receptor agonists, such as Ozempic, have emerged as potential treatments. GLP-1 receptor agonists regulate appetite and can promote weight loss. Some GLP-1 receptor agonists, though Food and Drug Administration (FDA)-approved for diabetes, are also used off-label for weight loss alone. Rapid weight and fat loss with these medications can lead to what has been called “Ozempic Face” on social media and in the lay press, where facial volume and fat are depleted, resulting in wrinkles and sagging skin. Prescribers rarely counsel patients about the potential impact on the face, and the plastic surgery community faces a challenge in managing the facial changes associated with rapid weight loss. Dermal fillers, skin tightening techniques, and surgical interventions are useful for both restoration of facial volume and to manage excess skin. Discontinuation of GLP-1 receptor agonists should be considered prior to general anesthesia due to delayed gastric emptying while on these medications. As the popularity of GLP-1 receptor agonists grows, facial plastic surgeons must be aware of both the impact on facial appearance and perioperative considerations.
Structural Characterization and Anticomplement Activity of an Acidic Heteropolysaccharide from Lysimachia christinae Hance
Authors: Hong Zhou , Zhou Li-Shuang , Zhao Zhi-Zhi , Yuan Guo-Qi , Wang Xiao-Jiang , Lu Yan , Chen Dao-Feng 
Published: August 2023

AbstractA novel acidic heteropolysaccharide (LCP-90-1) was isolated and purified from a traditional “heat-clearing” Chinese medicine, Lysimachia christinae Hance. LCP-90-1 (Mw,
20.65 kDa) was composed of Man, Rha, GlcA, Glc, Gal, and Ara, with relative molar ratios of 1.00: 3.00: 11.62: 1.31: 1.64: 5.24. The backbone consisted of 1,4-α-D-GlcpA,
1,4-α-D-Glcp, 1,4-β-L-Rhap, and 1,3,5-α-L-Araf, with three branches of β-D-Galp-(1 → 4)-β-L-Rhap-(1→,
α-L-Araf-(1→ and α-D-Manp-(1→ attached to the C-5 position of 1,3,5-α-L-Araf. LCP-90-1 exhibited potent anticomplement activity (CH50:
135.01 ± 0.68 µg/mL) in vitro, which was significantly enhanced with increased glucuronic acid (GlcA) content in its degradation production (LCP-90-1-A, CH50:
28.26 ± 0.39 µg/mL). However, both LCP-90-1 and LCP90-1-A were inactivated after reduction or complete acid hydrolysis. These observations indicated the important role of GlcA in LCP-90-1
and associated derivatives with respect to anticomplement activity. Similarly, compared with LCP-90-1, the antioxidant activity of LCP-90-1-A was also enhanced. Thus, polysaccharides with a
high content of GlcA might be important and effective substances of L. christinae.
Heart–Lung Interactions
Authors: Hamahata Natsumi , Pinsky Michael R. 
Published: August 2023

AbstractThe pulmonary and cardiovascular systems have profound effects on each other. Overall cardiac function is determined by heart rate, preload, contractility, and afterload. Changes in lung volume, intrathoracic pressure (ITP), and hypoxemia can simultaneously change all of these four hemodynamic determinants for both ventricles and can even lead to cardiovascular collapse. Intubation using sedation depresses vasomotor tone. Also, the interdependence between right and left ventricles can be affected by lung volume-induced changes in pulmonary vascular resistance and the rise in ITP. An increase in venous return due to negative ITP during spontaneous inspiration can shift the septum to the left and cause a decrease in left ventricle compliance. During positive pressure ventilation, the increase in ITP causes a decrease in venous return (preload), minimizing ventricular interdependence and will decrease left ventricle afterload augmenting cardiac output. Thus, positive pressure ventilation is beneficial in acute heart failure patients and detrimental in hypovolemic patients where it can cause a significant decrease in venous return and cardiac output. Recently, this phenomenon has been used to assess patient's volume responsiveness to fluid by measuring pulse pressure variation and stroke volume variation. Heart–lung interaction is very dynamic and changes in lung volume, ITP, and oxygen level can have various effects on the cardiovascular system depending on preexisting cardiovascular function and volume status. Heart failure and either hypo or hypervolemia predispose to greater effects of ventilation of cardiovascular function and gas exchange. This review is an overview of the basics of heart–lung interaction.
Acute Kidney Injury and Abnormalities on Brain Magnetic Resonance Imaging or Death in Infants with Hypoxic–Ischemic Encephalopathy: A Case–Control Study
Authors: DeSantis Eliza , Talekar Kiran , Dougherty Margaret , Carola David , Solarin Kolawole , McElwee Dorothy , Adeniyi-Jones Susan , Aghai Zubair H. 
Published: August 2023

Objective This study aimed to analyze the association between acute kidney injury (AKI) and abnormalities on brain magnetic resonance imaging (MRI) or death in neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE).
Study Design This is a retrospective case–control analysis of 380 neonates born at ≥35 weeks' gestation treated with therapeutic hypothermia for HIE. Death or abnormal brain MRI using the basal ganglia watershed scoring system was compared between neonates with and without AKI.
Results A total of 51 (13.4%) neonates had AKI. Infants with AKI had higher rates of the composite of death or abnormal brain MRI (74.5 vs. 38.3%; p < 0.001). Rate of death (21.6 vs. 5.5%; p < 0.001) and severe abnormalities on MRI or death (43.1 vs. 19.1%; p < 0.001) were also higher in neonates with AKI.
Conclusion AKI is strongly associated with abnormalities on brain MRI or death in neonates with HIE. Identification of AKI in this patient population may be helpful in guiding clinical management and predicting potential neurodevelopmental impairment.
Key Points
Countering the “wrong story”: a Participatory Action Research approach to developing COVID-19 vaccine information videos with First Nations leaders in Australia
Authors: Kerrigan Vicki , Park Deanna , Ross Cheryl , Herdman Rarrtjiwuy Melanie , Wilson Phillip Merrdi , Gunabarra Charlie , Tinapple Will , Burrunali Jeanette , Nganjmirra Jill , Ralph Anna P. , Davies Jane 
Published: August 2023

AbstractThe COVID-19 pandemic, coupled with the “infodemic” of misinformation, meant First Nations peoples in Australia’s Northern Territory were hearing “the wrong story” about COVID-19 vaccines. In March 2021, when the Australian government offered COVID-19 vaccines to First Nations adults there was no vaccine information designed with, or for, the priority group. To address this gap, we conducted a Participatory Action Research project in which First Nations leaders collaborated with White clinicians, communication researchers and practitioners to co-design 16 COVID-19 vaccine videos presented by First Nations leaders who spoke 9 languages. Our approach was guided by Critical Race Theory and decolonising processes including Freirean pedagogy. Data included interviews and social media analytics. Videos, mainly distributed by Facebook, were valued by the target audience because trusted leaders delivered information in a culturally safe manner and the message did not attempt to enforce vaccination but instead provided information to sovereign individuals to make an informed choice. The co-design production process was found to be as important as the video outputs. The co-design allowed for knowledge exchange which led to video presenters becoming vaccine champions and clinicians developing a deeper understanding of vaccine hesitancy. Social media data revealed that: sponsored Facebook posts have the largest reach; videos shared on a government branded YouTube page had very low impact; the popularity of videos was not in proportion to the number of language speakers and there is value in reposting content on Facebook. Effective communication during a health crisis such as the COVID-19 pandemic requires more than a direct translation of a script written by health professionals; it involves relationships of reciprocity and a decolonised approach to resource production which centres First Nations priorities and values.
Graphite resistive heated diamond anvil cell for simultaneous high-pressure and high-temperature diffraction experiments
Authors: Hwang Huijeong , Bang Yoonah , Choi Jinhyuk , Cynn Hyunchae , Jenei Zsolt , Evans William J. , Ehnes Anita , Schwark Iris , Glazyrin Konstantin , Gatta G. Diego , Lotti Paolo , Sanloup Chrystèle , Lee Yongjae , Liermann Hanns-Peter 
Published: August 2023

High-pressure and high-temperature experiments using a resistively heated diamond anvil cell have the advantage of heating samples homogeneously with precise temperature control. Here, we present the design and performance of a graphite resistive heated diamond anvil cell (GRHDAC) setup for powder and single-crystal x-ray diffraction experiments developed at the Extreme Conditions Beamline (P02.2) at PETRA III, Hamburg, Germany. In the GRHDAC, temperatures up to 2000 K can be generated at high pressures by placing it in a water-cooled vacuum chamber. Temperature estimates from thermocouple measurements are within +/−35 K at the sample position up to 800 K and within +90 K between 800 and 1400 K when using a standard seat combination of cBN and WC. Isothermal compression at high temperatures can be achieved by employing a remote membrane control system. The advantage of the GRHDAC is demonstrated through the study of geophysical processes in the Earth’s crust and upper mantle region.
Evaluation of a community-based
One Health
intervention to reduce the risk of Lyme disease in a high-incidence municipality
Authors: Potes Liliana , Bouchard Catherine , Rocheleau Jean-Philippe , Richard Lucie , Leighton Patrick , Pelletier Jérôme , Baron Geneviève , Aenishaenslin Cécile 
Published: August 2023

Abstract

Integrated interventions coherent with the
One Health
approach are required to maximize the effectiveness of tick-borne disease prevention. The objective of this study was to evaluate the feasibility of a community-based
One Health
preventive intervention in a municipality reporting a high incidence of Lyme disease (LD) in the province of Quebec, Canada. The intervention integrated several activities to promote the adoption of preventive behaviours in the community (community component), with the reduction of infected ticks in the environment (environmental component). To evaluate short-term effects of the community component, quantitative data on knowledge, attitudes, and practices (KAP) of citizens were collected using online questionnaires at the beginning of the intervention and 1 year later. To evaluate the implementation of the intervention, a qualitative approach was principally used, and individual interviews (n=37) were conducted with key informants. Results showed that having a high level of participation in the community activities included in the intervention was associated with a higher adoption of preventive measures at the end of the intervention, although participation was not significantly associated with changes in KAP over the intervention period. Interviews revealed that the community mobilization approach was perceived as an effective and sustainable way to empower citizens and researchers with regard to LD prevention. This study suggests that community-based interventions of this type offer a promising approach to the prevention of tick-borne diseases.
Nahu-kparilim (cattle caretakership): understanding the persistence of unfree Fulani labour and the (non)violent renegotiation of power relations in agrarian economies in northern Ghana
Authors: Eke Surulola 
Published: August 2023

ABSTRACT
This article focuses on how Fulani outsider status, often maintained through several generations, constitutes the basis for unequal labour, land and associated relations. It discusses how static forms of ‘fixed’ citizenship and socioeconomic immobility both maintain and intensify labour precarity, rendering the Fulani more vulnerable to the whims, caprices and avarice of their native ‘overlords’, as evidenced by the practice of nahu-kparilim in Ghana. The article’s main interest is thus land and labour injustice rather than pastoral production and related livelihood activities. Integrating the theories of unfreedom, social reproduction and subalternity, the article contributes to unfree labour studies by demonstrating that despite being constrained in complex ways, unfree labourers have the agency to renegotiate power relations. This advances the idea of unfree labourers’ agency which, in comparison to their immiseration, receives less attention in scholarship on unfreedom.
Development and industrial application of integrated computational materials engineering
Authors: Furrer David 
Published: August 2023

Abstract
Materials and manufacturing engineering are continuing to advance in part to computational materials and process modeling and associated linkages with associated interdisciplinary efforts across all engineering, manufacturing, and quality disciplines. Computational modeling has enabled virtual processing, prediction and assessment of potential new materials and manufacturing processes, without or with limited need to perform costly and time-consuming physical trials. Development and integration of computational materials and process engineering requires a number of seemingly disparate critical technical elements, making this evolving computational capability very complicated. Accurate and validated models are supporting rapid material, process, and component development, and additionally qualification and certification of new final products through integrated computational materials engineering (ICME). These capabilities are driving further industrial utilization of computational material and process modeling with formalized linkages and integration within multidisciplinary engineering workflows. Past utilization, present applications and potential future development activities indicate that industry has now fully embraced the tools and methods, and overarching engineering framework of ICME.