bluuebunny/crossref_metadata_2025_split huggingface dataset:
From the Forest to the City: the Arrival of Dragonflies and Damselflies to the Urban Jungle
Authors: Suárez-Tovar Catalina María , Rocha-Ortega Maya , Juen Leandro , Córdoba-Aguilar Alex 
Published: March 2023

Abstract
Can we predict which taxonomic groups and morphological or behavioral traits are favoured during urbanization? Here we have revised those odonate (dragonflies and damselflies) species are present in urban areas around world, their body size, body colour, sexual dimorphism, flight mode, habitat preference and mate guarding strategy. We wanted to know which of these traits are apparently favoure/ non-favoured in urban odonates. We found 88 urbanization-tolerant (Aeshnidae, Libellulidae and Coenagrionidae) and 87 urbanization-sensitive (Lestidae, Calopterygidae, Gomphidae) species. A phylogenetic path analysis showed that smaller dragonflies and damselflies species seem better adapted to urban environments. For dragonflies, yellow- or red-colored species as well as less sexually dimorphic were more frequent in urban areas. For damselflies species, those associated to lentic waters and with lesser mate guarding were more likely to use urban areas. We discuss the underlying physiological mechanisms linked to such urban-surviving ability as well as how we can use such information for conservation purposes. Indeed, it seems that odonates are well adapted to urbanization.
Rice Culture and Family Size
Authors: YUAN ZHENG , ZHU Fengshu 
Published: March 2023

Abstract
This paper studied the influence of rice culture on family size. Rice planting and the suitability of rice planting have significant positive effect on family size. Using the rice/grain yield ratio and rice/grain planting area ratio to replace the rice planting, the conclusion is still robust. Using the reservoir density as the instrumental variable of rice planting, the influence is still significant. Rice planting leads to stronger collectivism culture, higher childbearing willingness, son preference, lower divorce rate and less family division tendency, resulting larger family size. Therefore, the fertility-incentive policy may be more effective in rice planting areas.
Performance of cocultivation of Chlorella vulgaris and four different fungi in biogas slurry purification and biogas upgrading by induction of strigolactone (GR24) and endophytic bacteria
Authors: Ji Yuan , Huang Luanbei , Wang Zhengfang , Xu Jie , Wei Jing , Zhao Yongjun 
Published: March 2023

Abstract
This study aimed to determine the best fungi to form the algal-bacterial-fungi symbiotic system and identify the optimal conditions for the synchronous processing of biogas slurry and biogas. Chlorella vulgaris (C. vulgaris) and endophytic bacteria (S395-2) isolated from it and four different fungi (Ganoderma lucidum, Pleurotus ostreatus, Pleurotus geesteranus, and Pleurotus corucopiae) were used to form different symbiotic systems. Four different concentrations of GR24 were added to systems to examine the growth characteristics, the content of chlorophyll a (CHL-a), the activity of carbonic anhydrase (CA), the photosynthetic performance, the removal of nutrients, and the biogas purification performance. The results suggested that the growth rate, CA, CHL-a content, and photosynthetic performance of the C. vulgaris-endophytic bacteria-Ganoderma lucidum symbiosis were higher than the other three symbiotic systems when 10-9 M GR24 was added. The highest nutrients/CO2 removal efficiency 78.36 ± 6.98% for chemical oxygen demand (COD), 81.63 ± 7.35% for total nitrogen (TN), 84.05 ± 7.16% for total phosphorus (TP) and 65.18 ± 6.12% for CO2 was obtained under the above optimal conditions. This approach will provide a theoretical basis for the selection and optimization of an algal-bacterial-fungi symbiotic system for biogas slurry and biogas purification.
A Novel Interpretation for pressure pulse wavepropagation arterial system
Authors: R Ravichandran 
Published: March 2023

Abstract
In this paper is dedicated to the improvement of mathematical model with the aim of studyingtheoretically the propagation of blood pressure pulse waves through nonlinear blood vessel wall.The elastic modulus of the blood vessel, the radius of the tube that influenced the pulse wavepropagation will be explained. We have deliberated the amplitude modulation of nonlinear wavesin such a composite system by use of the reductive perturbation method. The governing evolutionequation is obtained as the famous nonlinear Schr¨odinger equation (NLS) using Hirota bilinearizationprocedure, subsequently found the solitons exhibit inelastic collision which we meanthat solitons change its shape after the collision. Further, we invoke the Exp-function methodaided with symbolic computation and obtain a series of solitonic excitations of arterial profilesadmitting the propagation of solitary pulse wave medium. It is create that the solitary pulsescan be excited by the nonlinear self-steepening at shock fronts.The significance of our analysis toblood solitary waves in arteries is discussed.
ALK-positive multisystemic malakoplakia: a case report
Authors: Zhang Xiao-Ying , Li Jun , Chen Shui-lian , Li Ying , Wang Hao , He Jin-hua 
Published: March 2023

Abstract
Background: Malakoplakia is a rare inflammatory disease of the urogenital tract. There have been no reports of malakoplakia expressing anaplastic lymphoma kinase (ALK) to date. Here, we present one case of ALK-positive multisystemic malakoplakia and discuss the clinical significance.
Case Presentation: A 65-year-old Chinese woman visited our hospital for treatment of right lumbar and abdominal pain of 1 month’s duration. Imaging revealed a soft tissue shadow measuring 59 × 58 × 45 mm at the middle and upper lateral margins of the right kidney. The boundary between the right posterior lobe of the liver and the hepatic curvature of the colon was not clear, and the adjacent hepatic curvature of the colon was slightly thickened. Colonoscopy revealed a 1.6-cm hummock-shaped protrusion in the middle of the ascending colon. Right nephrectomy and partial liver resection were performed. Microscopically, sheets of histiocytes with poor intercellular adhesion were seen, with Michaelis–Gutmann bodies present in both the intracellular and extracellular interstitium. CD10-, CD68-, and CD163-positive cells were present, with Michaelis–Gutmann bodies confirmed by staining with Alcian blue, periodic acid-Schiff (PAS), periodic acid-Schiff with diastase, Von Kossa, and Prussian blue. Abnormal ALK1 and ALK (D5F3) expression was observed in the cytoplasm and nucleus of cells. However, ALK gene mutation was not detected by fluorescence in situ hybridization or whole exome next-generation sequencing. The pathological diagnosis was ALK-positive multisystemic malakoplakia. The antibiotics imipenem and vancomycin were started based on the results of drug sensitivity analysis and the patient was subsequently discharged. She experienced no discomfort during 30 months of follow-up.
Conclusion: This is the first reported case of ALK-positive multisystemic malakoplakia. The expression, mechanism, and clinical significance of ALK in this disease are worthy of further study.
Dosimetric Impacts on Height Development after Radiotherapy for Intracranial Non-germinomatous Germ Cell Tumours
Authors: Deng Guanhua , Zhou Zhaoming , Li Juan , Lai Mingyao , He Jing , Hu Qingjun , Zhang Ping , Dai Peng , Luo Longhui , Zhen Junjie , Li Shaoqun , Zhou Jiangfen , Ye Mingting , Hong Weiping , Shan Changguo , Hu Xiaolei , Chen Longhua , Wen Lei , Cai Linbo , Zhou Cheng 
Published: March 2023

Abstract
Objectives
Intracranial non-germinomatous germ cell tumours (NGGCTs) are rare pediatric central nervous system (CNS) tumours. Growth impairment induced by radiation treatment was rarely evaluated. We aimed to study the impacts of radiotherapy on height development as well as the dosimetric constraints, providing potential insights for hormonal treatment.
Methods
A total of 148 pediatric patients diagnosed with NGGCTs were retrospectively studied. Sex, age at irradiation, physical doses and biologically effective dose (BED), height and endocrine status were obtained for analysis. The cumulative change in height was assessed using age-matched normalized height (ANH). Cumulative physical doses and BEDs for the whole brain and pituitary were derived via dose-volume histograms (DVHs) and BED-volume histograms (BEDVHs).
Results
In contrast to patients > 11.5 year., linear correlations between ANH and cumulative physical doses as well as BEDs to the whole brain and pituitary were identified in patients ≤ 11.5 year. Dosimetric constraints to the pituitary was 36 Gy for physical dose (AUC = 0.70 [95% CI, 0.54–0.86], P < 0.05) and 63 Gy2 BED (AUC = 0.69 [95% CI, 0.53–0.86], P < 0.05). Impaired hormone secretion in terms of GH and TSH were observed following cranial irradiation (both P < 0.001), particularly for those with tumours at the suprasellar region (GH: P < 0.01, TSH: P < 0.001). In contrast to patients > 11.5 year., the ANH for patients with tumours in the suprasellar region was significantly lower than those in the other locations (P < 0.01).
Conclusions
Our study revealed the impacts of cumulative doses and tumour locations for radiation-associated growth impairment. Reduced levels of GH and TSH were observed in patients ≤ 11.5 year. with tumours particularly in the suprasellar region.
Age-period-cohort analysis of lung cancer mortality inequalities in Southern Spain: missed opportunities for implementing equitable tobacco control policies
Authors: Córdoba-Doña Juan Antonio , Benítez-Rodríguez Encarnación , Escolar-Pujolar Antonio , Santos-Sanchez Vanessa 
Published: March 2023

AbstractBackground: Lung cancer mortality in European countries shows different epidemiological patterns according to sex and socioeconomic variables. Some countries show decreasing rates in both sexes, while others show a delayed profile, with increasing mortality in women, inconsistently influenced by socioeconomic status. Our aim was to evaluate the effect of age, period and birth cohort on lung cancer mortality inequalities in men and women in Andalusia, the southernmost region in Spain. Methods: We used the Longitudinal Database of the Andalusian Population, which collects demographic and mortality data from the 2001 census cohort of more than 7.35 million Andalusians, followed up between 2002 and 2016. Mortality rates were calculated for men and women by educational level, and small-area deprivation. Poisson models were used to assess trends in socioeconomic inequalities in men and women. Finally, age-period-cohort (APC) models were used separately for each educational level and gender. Results: There were 39,408 lung cancer deaths in men and 5,511 in women, yielding crude mortality rates of 78.1 and 11.4 x 105person-years, respectively. Negative educational inequalities in mortality increased in men: i.e. the rate ratio for primary studies compared to university studies increased from 1.30 (CI95:1.18–1.44) to 1.57 (CI95:1.43–1.73). For women, positive educational inequalities tended to decrease moderately. In APC analysis, a decreasing period effect in men and an increasing one in women were observed. Cohort effect differed significantly by educational level. The lower the educational level, the earlier the peak effect was reached among both men and women, with a 25-year difference between the least-educated and college-educated men and 12-year difference between the least-educated and college-educated women. The decline of mortality followed the reverse pattern, with the best-educated groups experiencing declining rates with earlier birth cohorts. Conclusions: Our study reveals that APC analysis by education helps to uncover changes in trends occurring in different socioeconomic and gender groups, which, combined with data on smoking prevalence, provide important clues for action. Despite its limitations, this approach to the study of lung cancer inequalities allows for the assessment of gaps in historical and current tobacco policies and the identification of population groups that need to be prioritised for public health interventions.
Economic evaluation in implementation science: A reconciled approach evaluating programmes to increase the uptake of magnesium sulphate in pre-term births
Authors: Sillero-Rejon Carlos , Hollingworth William , McLeod Hugh , Opmeer Brent C. , Luyt Karen 
Published: March 2023

Abstract
Background: Methods for the economic evaluation of implementation initiatives to increase the uptake of cost-effective healthcare interventions are not standardised. Value of implementation and policy cost-effectiveness are two proposed approaches. This research aims to compare these two methods and propose a standardised approach. To illustrate this, we evaluated two implementation programmes to increase magnesium sulphate (MgSO4) uptake in preterm labour to reduce the risk of cerebral palsy: i) the National PReCePT Programme (NPP) which provided regional support and funded clinical time in maternity units in England, and ii) an enhanced support programme (ESP) with additional unit-level coaching and extra funded time, which was nested within NPP and subject to a cluster RCT.
Methods: After summarising value of implementation and policy cost-effectiveness methods, we explored the extent to which the two methods can be viewed as mathematically equivalent for the purpose of evaluating the NPP (versus pre-existing trends) and the ESP (versus the NPP) calculating their incremental cost-effectiveness ratios, net monetary benefits, and their probability of being cost-effective.
Results: We demonstrate that value of implementation and policy cost-effectiveness methods can be expressed in mathematically equivalent terms and propose a standardised stepwise approach. Both methods depend on the change in the uptake of the healthcare technology, cost of the implementation activity, size of the eligible population affected over time, and the cost-effectiveness of the healthcare technology. We illustrated our standardised approach in two economic evaluations: the NPP generated a societal lifetime net monetary benefit of £30,247 per maternity unit over 12 months, at a willingness-to-pay threshold of £20,000; the probability of being cost-effective was 98%. In contrast, the ESP generated a net monetary benefit of -£28,682 per maternity unit in comparison to the NPP; the probability of being cost-effective was 22%.
Conclusions: Policy cost-effectiveness and value of implementation approaches can be represented by a standardised stepwise method for the economic evaluation of implementation initiatives. Our illustrative examples show how the value of different quality improvement interventions for the same cost-effective treatment can be evaluated and compared. Our standardised method may facilitate a more systematic assessment of the value for money of implementation initiatives, which should be viewed as an important component of implementation research.
Randomized Strategies for Robust Combinatorial Optimization with Approximate Separation
Authors: Kawase Yasushi , Sumita Hanna 
Published: March 2023

Abstract
In this paper, we study the following robust optimization problem. Given a set family representing feasibility and candidate objective functions, we choose a feasible set, and then an adversary chooses one objective function, knowing our choice. The goal is to find a randomized strategy (i.e., a probability distribution over the feasible sets) that maximizes the expected objective value in the worst case. This problem is fundamental in wide areas such as artificial intelligence, machine learning, game theory, and optimization.To solve the problem, we provide a general scheme based on the dual linear programming problem.In the scheme, we utilize the ellipsoid algorithm with the approximate separation algorithm. We prove that there exists an α-approximate algorithm for our robust optimization problem if there exists an α-approximate algorithm for finding a (deterministic) feasible set that maximizes a non-negative linear combination of the candidate objective functions.Using our result, we provide approximation algorithms for the max-min fair randomized allocation problem and the maximum cardinality robustness problem with a knapsack constraint.
Dry matter yield and egg organoleptic attributes of Moringa oleifera and Allium sativum fed laying hens
Authors: Agbetuyi Oluwafemi Abel , Ekeocha Anthony Henry , Aganga Ademiju Adeolu 
Published: March 2023

Abstract
Dry matter yields of Moringa oleifera leaf powder (MLP) and Allium sativum bulb powder (ABP), and egg organoleptic attributes of laying hens fed dietary treatments was determined using 240 ISA Brown laying hens of 18 weeks old. The birds were randomly assigned to 5 dietary treatments with 4 replicates of 12 birds each. The treatments were T1 = control diet, T2 = MLP replaced with soya bean meal at 1%, T3 = MLP replaced with soya bean meal at 3%, T4 = MLP replaced with soya bean meal at 1% + 0.1% ABP and T5 = MLP replaced with soya bean meal at 3% + 0.3% ABP. The feeding trial lasted for 6 months. Data were collected on dry matter yields and egg organoleptic attributes. Data collected were subjected to General Linear Model Procedure of SAS v13. Significant means were separated using Tukey’s Procedure tested at a 5% level of significance. The average moisture content in Moringa oleifera leaf and Allium sativum bulb were about 75.32% and 78.28% while dry matter yields were 24.68% and 21.72% respectively. Colour, taste, off-flavour and overall acceptability of the eggs were significantly (p < 0.05) influenced by the inclusion of MLP and ABP in laying diets. Eggs in T5 recorded the highest value (8.05) of overall acceptability and had the lowest off-flavour (2.38). The dry matter yields are economically useful in poultry diet, while the dietary treatments lead to an improvement in the value chain of poultry eggs, owning to consumers preference.
Sodium butyrate induces ferroptosis in endometrial cancer cells via the RBM3/SLC7A11 axis
Authors: Wang Ziwei , Shu Wan , Zhao Rong , Liu Yan , Wang Hongbo 
Published: March 2023

Abstract
Ferroptosis is a form of programmed cell death with important biological functions in the progression of various diseases, and targeting ferroptosis is a new tumor treatment strategy. Studies have shown that sodium butyrate plays a tumor-suppressing role in the progression of various tumors, however, the mechanism of NaBu in endometrial cancer is unclear. Cell viability, clone formation, proliferation, migration, invasion abilities and cell cycle distribution were assessed by CCK8 assay, Clone formation ability assay, EdU incorporation, Transwell chambers and flow cytometry. The level of ferroptosis was assayed by the levels of ROS and lipid peroxidation, the ratio of GSH/GSSG and the morphology of mitochondria. Molecular mechanisms were explored by metabolome, transcriptome, RNA-pulldown and mass spectrometry. The in-vivo mechanism was validated using subcutaneous xenograft model. In this study, NaBu was identified to inhibit the progression of endometrial cancer in vitro and in vivo. Mechanistically, RBM3 has a binding relationship with SLC7A11 mRNA. NaBu indirectly downregulates the expression of SLC7A11 by promoting the expression of RBM3, thereby promoting ferroptosis in endometrial cancer cells. In conclusion, Sodium butyrate can promote the expression of RBM3 and indirectly downregulate the expression of SLC7A11 to stimulate ferroptosis, which may be a promising cancer treatment strategy.
Comprehensive Analysis of the role of DIAPH3 in Cancers and Validation in Bladder Cancer
Authors: Chen Kai , Wang Xiao-ming , Li Deng-xiong , Bai Yun-jin , Wu Rui-cheng , Han Ping 
Published: March 2023

Abstract
Background
Cancer is still a serious public health concern across the world at present. Previous studies have suggested that DIAPH3 might play a role in tumorigenesis and progression. However, the prognostic and immunological role of DIAPH3 in human cancers remains unclear.
Method
The TCGA, GTEx, TIMER2 and GEPIA2 database were utilized to investigate expression difference of DIAPH3 between normal tissues and cancers. For survival analysis, K-M plotter and Pronogscan website were employed. The genetic alteration analysis for DIAPH3 were conducted via cBioPortal database. The DIAPH3 related proteins were screened by the STRING website, and incorporated into KEGG and GO analysis using ‘clusterProfiler' package. Then, we used CIBERSORT algorithm to investigate the percentage of TIICs. For correlation analysis with molecular and immunological subtype, TMB, and MSI, the TISIDB database and SangerBox platform were utilized. To validate the function of DIAPH3 in BLCA, human bladder cancer cells T24 and 5637 were transfection by siRNA and Lipofectamine 8000. The efficiency of knockdown towards target gene was evaluated by qRT-PCR and Western Blot. The CCK-8 assays, clone formation assays, transwell, and wound healing assays were performed to test the proliferation, migration and invasion ability of cells.
Results
Various type of cancers had increased DIAPH3 expression than normal tissues, and DIAPH3 expression played an adverse prognostic role in most of cancers. Then, function analyses indicated that actin, microtubule and phagocytosis related pathways were enriched in DIAPH3 related proteins. DIAPH3 was strongly correlated to tumor immunity cells infiltration, especially MDSC. In addition, the link between DIAPH3 with immunological subtype, molecular subtype, TMB, and MSI were also observed. Furthermore, the knockdown of DIAPH3 could inhibit the proliferation, migration and invasion of bladder cancer cells.
Conclusion
In summary, our study demonstrated a correlation between DIAPH3 expression and prognosis, clinicopathological characteristics, immune infiltration cells, and immunotherapy response based on a pan-cancer analysis. The knockdown of DIAPH3 inhibited the proliferation, migration and invasion of bladder cancer cells. These findings might expand our knowledge of DIAPH3 as potential predictive biomarker or therapy target for cancers.
Antioxidant effects of marjoram (Origanum majorana l.) and its improvement of the intestinal mucosa morphology in pulmonary hypertensive chickens
Authors: Bahadoran Shahab , Teymouri Younes , Hassanpour Hossein , Mohebbi Abdonnaser 
Published: March 2023

Abstract
Background
Marjoram as an herbal plant has different medicinal effects. In this study, the effects of dietary marjoram extract on the enzymatic oxidant (lipid peroxidation)/antioxidant status (enzyme activity and gene expression), growth performance, intestinal mucosa morphology (duodenum), and pulmonary hypertensive response were evaluated in cold-induced pulmonary hypertensive chickens.
Results
Chicks were reared for 35 days and treated with 0.05% vitamin C (positive control) and 0 (control), 0.1, or 0.2% marjoram extracts. Pulmonary hypertension syndrome was induced using cold stress in all groups. RV: TV ratio was lower in all treatments of chickens than in the control (p < 0.05). Weight gain of chickens in all treatments was increased in days 22–35 compared to control (p < 0.05) while the feed conversion ratio was only decreased in the chickens fed marjoram 0.2%. Lipid peroxidation was decreased in all groups while the activity of catalase (CAT) was increased in the marjoram 0.2% group compared to the control (p < 0.05). In the lung, superoxide dismutase (SOD), CAT, and glutathione peroxidase (GPX) transcripts were decreased in the marjoram 0.2% group compared to the control (p < 0.05). In the right ventricle of the heart, SOD and CAT transcripts were increased in the marjoram 0.2% group compared to other groups of chickens whereas GPX transcript was decreased (p < 0.05). The duodenal villus length and surface area in the chickens fed vitamin C, and villus lamina propria thickness in the chickens fed vitamin C and marjoram were higher than control (p < 0.05).
Conclusion
The dietary supplementation of marjoram could modulate pulmonary hypertensive response in broilers and ameliorate intestinal secretion through its antioxidant effects.