bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review: Improving access to mental health interventions for children from birth to five years: A Scoping Review
Authors: Hickey Lyndal , Harms Louise , Evans Jackson , Noakes Tahnee , Lee Henrietta , McSwan Amity , Bean Helena , Hope Judith , Allison Lynne , Price Sophie , Harris Nicole 
Published: May 2023

BackgroundIn spite of infants and children aged 0–5 years experiencing mental health difficulties being estimated to be in the range of 6%–18% globally, the mental health care needs for this age group are often overlooked in the design of specialist mental health services. Although there is increasing recognition of the importance of infant mental health services and treatments for younger children, access remains a barrier. Mental health services specifically designed for children 0–5 years are vital; however, little is known about how these services ensure access for infants at risk of mental health difficulties and their families. This scoping review seeks to address this knowledge gap.MethodsA scoping review methodology framework was used to search for relevant articles published between January 2000 and July 2021, identified using five databases: MEDLINE, CINAHL, PsycINFO, SocIndex and Web of Science. The selection of studies was based on empirical research about access to infant mental health services and models of care. A total of 28 relevant articles met the eligibility criteria for inclusion in this review.ResultsFindings can be summarised under five broad themes: (1) accessibility for at‐risk populations (2) the importance of early detection of infants in need of mental health services and interventions; (3) the promotion of culturally responsive services and interventions; (4) ensuring the sustainability of IMH services and programs and (5) the integration of innovative interventions to improve existing practice models.ConclusionsThe findings from this scoping review highlight barriers to access and provision of infant mental health services. Future infant mental health service design, informed by research, is needed to improve access for infants and young children with mental health difficulties and their families.
ANP32B suppresses B‐cell acute lymphoblastic leukemia through activation of PU.1 in mice
Authors: Yang Qian , Liu Hao‐Ran , Yang Shuo , Wei Yu‐Sheng , Zhu Xiao‐Na , Zhi Zhe , Zhu Di , Chen Guo‐Qiang , Yu Yun 
Published: May 2023

AbstractANP32B, a member of the acidic leucine‐rich nuclear phosphoprotein 32 kDa (ANP32) family of proteins, is critical for normal development because its constitutive knockout mice are perinatal lethal. It is also shown that ANP32B acts as a tumor‐promoting gene in some kinds of cancer such as breast cancer and chronic myelogenous leukemia. Herein, we observe that ANP32B is lowly expressed in B‐cell acute lymphoblastic leukemia (B‐ALL) patients, which correlates with poor prognosis. Furthermore, we utilized the N‐myc or BCR‐ABLp190‐induced B‐ALL mouse model to investigate the role of ANP32B in B‐ALL development. Intriguingly, conditional deletion of Anp32b in hematopoietic cells significantly promotes leukemogenesis in two B‐ALL mouse models. Mechanistically, ANP32B interacts with purine rich box‐1 (PU.1) and enhances the transcriptional activity of PU.1 in B‐ALL cells. Overexpression of PU.1 dramatically suppresses B‐ALL progression, and highly expressed PU.1 significantly reverses the accelerated leukemogenesis in Anp32b‐deficient mice. Collectively, our findings identify ANP32B as a suppressor gene and provide novel insight into B‐ALL pathogenesis.
Pitfalls of mitral regurgitation assessment in the presence of mitral valve prolapse
Authors: Zach Veronika , Morris Daniel Armando , Pieske Burkert , Schneider‐Reigbert Matthias 
Published: May 2023

AbstractAdequate grading of mitral regurgitation (MR) in patients with mitral valve prolapse (MVP) in the presence of mid‐late systolic jets can represent a major challenge. In this entity, jets are commonly overestimated by echocardiography. Correct quantification is crucial and highly relevant for the further management and prognosis of these oftentimes young patients. This case points out potential pitfalls and underlines the importance to systematically include qualitative, quantitative, and semi‐quantitative parameters into the echocardiographic assessment.
Day‐to‐day individual alpha frequency variability measured by a mobile EEG device relates to anxiety
Authors: Sidelinger Lauren , Zhang Mengsen , Frohlich Flavio , Daughters Stacey B. 
Published: May 2023

AbstractThe individual alpha frequency (IAF) has previously been identified as a unique neural signature within the 8–12 Hz alpha frequency band. However, the day‐to‐day variability of this feature is unknown. To investigate this, healthy participants recorded their own brain activity daily at home using the Muse 2 headband, a low‐cost consumer‐grade mobile electroencephalography (EEG) device. Resting‐state recordings of all participants using a high‐density (HD) EEG were also collected in lab before and after the at‐home data collection period. We found that the IAF extracted from the Muse 2 was comparable to that of location‐matched HD‐EEG electrodes. No significant difference was found between these IAF values before and after the at‐home recording period for the HD‐EEG device. Similarly, there was also no statistically significant difference between the beginning and end of the at‐home recording period for the Muse 2 headband over 1 month. Despite the group‐level stability of IAF, the individual‐level day‐to‐day IAF variability carried mental health‐relevant information: Exploratory analyses revealed a relationship between IAF day‐to‐day variability and trait anxiety. We also noted that the IAF systematically varied across the scalp and although the Muse 2 electrodes do not cover the occipital lobe where alpha oscillations were the strongest, IAFs measured in the temporal lobe and occipital lobe were strongly correlated. Altogether, these results show that mobile EEG devices are useful for studying IAF variability. The relationship between day‐to‐day variability of region‐specific IAF and the dynamics of psychiatric symptoms, particularly anxiety, should be further investigated.
Hybrid computer aided diagnostic system designs for screen film mammograms using DL‐based feature extraction and ML‐based classifiers
Authors: Rani Jyoti , Singh Jaswinder , Virmani Jitendra 
Published: May 2023

AbstractMammography is most popular imaging method used often in predicting breast cancer within women above age of 38 years. Various computer‐assisted algorithms have been employed for classifying breast masses as normal or malignant using screen film mammographic (SFM) images. In present research work, exhaustive experimentations have been carried out with nine deep learning‐based convolutional neural networks (CNNs) belonging to the three different categories of CNN architectures including (a) simple convolution‐based series models, that is VGG16 and VGG19 (b) simple convolution‐based directed acyclic graph (DAG) model, that is GoogleNet and (c) dilated convolution‐based DAG models, that is ResNet18, ResNet50, Inceptionv3, XceptionNet, ShuffleNet and MobileNet‐V2, for binary classification of the mammographic masses with SFM images. The experimental work has been carried out using 518 mammographic images taken from DDSM dataset with 208 images ϵ benign class and 310 images ϵ malignant class, respectively. The encoder‐decoder based semantic segmentation network model, that is ResNet50 has been used for the segmentation of mammographic masses from SFM images. The segmented masses images obtained from the ResNet50 model are subjected to classification experiments. To design a robust hybrid classifier design, that is, deep learning (DL)‐based feature extraction and machine learning (ML)‐based classification, the first step is to obtain an optimal DL‐based feature extractor for classification task. The optimal feature set obtained by the best performing CNN Model, that is, VGG 19 has been subjected to correlation‐based feature extraction and ML‐based classifiers including (i) adaptive neuro fuzzy classifier‐linguistic hedges (ii) principal component analysis‐ support vector machine classifier and (iii) GA‐SVM classifier to yield an optimal hybrid computer aided diagnostic (CAD) system design. It is found that hybrid CAD system using VGG19 as feature extractor and ANFC‐LH as classifier yields 96% the highest classification accuracy. The other performance parameters yield values, that is 96% sensitivity, 96% specificity, 96% F‐score, 96% precision and 92% MCC, which indicates a best prediction of binary classification. The test images which were misclassified by these hybrid CAD system designs were analysed subjectively by experienced participating radiologist. The results obtained by present work suggests that proposed hybrid CAD system with VGG19 Network model acting as feature extractor and ANFC‐LH classifier can be employed for the differential diagnosis of benign as well as malignant mammographic masses using SFM images in a routine clinical setting.
Validity of self‐reported migraine in adolescents and children
Authors: Kellier Danielle J. , de Prado Blanca Marquez , Haagen Dana , Grabner Philip , Raj Nichelle , Lechtenberg Lara , Velasquez Gerardo , Hsu Jesse Y. , Farrar John T. , Hershey Andrew D. , Szperka Christina L. 
Published: May 2023

AbstractObjectiveTo assess agreement for migraine day between self‐report and diagnostic guidelines for children and adolescents using a headache diary.BackgroundTrial guidelines recommend prospective collection of headache features and adoption of migraine day as an outcome measure, but there is no clear consensus on the definition of migraine day.MethodsThis is a secondary analysis of data from two projects—a prospective cohort study validating a pediatric scale of treatment expectancy and a clinical trial of occipital nerve blocks to treat status migrainosus. Participants completed a text message‐based diary for 4 or 12 weeks (depending on treatment), and a detailed headache assessment on a random 20% of headache days. Using this assessment, we determined whether a headache day qualified for migraine or probable migraine, based on the International Classification of Headache Disorders, 3rd edition (ICHD‐3).ResultsOf 122 enrolled children and adolescents, 106 (86.9%) completed ≥1 detailed headache assessment (438 entries). We found moderate agreement between self‐reported and ICHD‐derived migraine day, with a Cohen's Kappa of 0.50 (positive predictive value [PPV]: 0.66; negative predictive value [NPV]: 0.85; correlation: 0.51). Allowing for ICHD‐derived probable migraine significantly increased PPV (0.66 vs. 0.94; 95% CI: 0.57–0.74 vs. 0.90–0.97), but decreased NPV (0.85 vs. 0.293; CI: 0.77–0.90 vs. 0.199–0.40), Cohen's Kappa (0.50 vs. 0.237; CI: 0. 389–0.60 vs. 0.139–0.352), and correlation (r = 0.51 vs. 0.302; CI: 0.41–0.61 vs. 0.192–0.41). Pain severity (OR: 5.7; CI: 2.39–13.8), photophobia (OR: 4.1; CI: 1.02–16.6), and phonophobia (OR: 7.5; CI: 1.95–29.3) were significantly associated with participants' perception of migraine.ConclusionWe found only moderate agreement between self‐reported and ICHD‐derived migraine day, suggesting both measures are not equal but may represent overlapping aspects of migraine as a disease. This highlights the difficulty of applying ICHD criteria to individual attacks. We recommend greater methodological transparency in future research to avoid readers conflating both measures.
Validation of the Utah Photophobia Symptom Impact Scale (version 2) as a headache‐specific photophobia assessment tool
Authors: Cortez Melissa M. , Martindale Cecilia , Brennan K. C. , Kean Jacob , Millar Morgan M. , Knudson Alexander , Katz Bradley J. , Digre Kathleen B. , Presson Angela P. , Zhang Chong 
Published: May 2023

AbstractObjectiveTo present an updated version of the Utah Photophobia Symptom Impact Scale version 2 (UPSIS2), providing robust clinical and psychometric validation, to improve headache‐specific evaluation of light sensitivity and headache‐related photophobia.BackgroundThe original UPSIS filled a gap in available tools for assessment of headache‐associated light sensitivity by providing patient‐reported evaluation of the impact of light sensitivity on activities of daily living (ADLs). We have since revised the original questionnaire to provide a more robust item construct and refined validation approach.MethodsWe conducted a psychometric validation of the UPSIS2 through a primary analysis of an online survey of volunteers with recurrent headaches recruited from the University of Utah clinics and surrounding community. Volunteers completed the original UPSIS and UPSIS2 questionnaire versions in addition to measures of headache impact, disability, and frequency. The UPSIS2 now includes a pre‐defined recall period and a 1–4 Likert scale with standardized response anchors to improve clarity. Internal construct validity, external construct validity, and test–retest reliability, were evaluated.ResultsResponses were obtained from 163 volunteers, with UPSIS2 scores ranging from 15 to 57 (out of a possible 15–60) with a mean (standard deviation) of 32.4 (8.80). Construct validity was satisfactory, as evidenced by sufficient unidimensionality, monotonicity, and local independence. Reliability was excellent, with Rasch test reliability = 0.90 and Cronbach's alpha = 0.92, and an intraclass correlation of 0.79 (95% confidence interval 0.65–0.88) for participants who took the test twice. UPSIS2 correlates well with other headache measures (Spearman's correlations >0.50), as well as the original UPSIS (Spearman's correlation = 0.87), indicating good convergent validity. UPSIS2 scores differ significantly across International Classification of Headache Disorders (third edition) groups, indicating good known group validity.ConclusionThe UPSIS2 provides a well‐validated headache‐specific outcome measure for the assessment of photophobia impact on ADLs.
Patient and public co‐creation of healthcare safety and healthcare system resilience: The case of COVID‐19
Authors: Albutt Abigail , Ramsey Lauren , Fylan Beth , Grindey Chloe , Hague Isabel , O'Hara Jane K. 
Published: May 2023

AbstractIntroductionHealthcare system resilience is a conceptual approach that seeks to explore how health services adapt and respond to variability in demand and resources. As has been witnessed since the beginning of the COVID‐19 pandemic, healthcare services have undergone many reconfigurations. One understudied aspect of how the ‘system’ is able to adapt and respond is the contribution of key stakeholders—patients and families, and in the context of the pandemic, the general public as a whole. This study aimed to understand what people were doing during the first wave of the pandemic to protect the safety of their health, and the health of others from COVID‐19, and the resilience of the healthcare system.MethodsSocial media (Twitter) was used as a method of recruitment due to its ability for social reach. Twenty‐one participants took part in 57 semistructured interviews over three time points from June to September 2020. The included an initial interview and invitation to two follow‐up interviews after 3 and 6 weeks. Interviews were conducted virtually using Zoom—an encrypted secure video conferencing software. A reflexive thematic analysis approach to analysis was used.ResultsThree themes, each with its own subthemes were identified in the analysis: (1) A ‘new safety normal’; (2) Existing vulnerabilities and heightened safety and (3) Are we all in this together?ConclusionThis study found that the public had a role in supporting the resilience of healthcare services and systems during the first wave of the pandemic by adapting their behaviour to protect themselves and others, and to avoid overwhelming the National Health Service. People who had existing vulnerabilities were more likely to experience safety gaps in their care, and be required to step in to support their safety, despite it being more difficult for them to do so. It may be that the most vulnerable were previously required to do this extra work to support the safety of their care and that the pandemic has just illuminated this issue. Future research should explore existing vulnerabilities and inequalities, and the heightened safety consequences created by the pandemic.Patient and Public ContributionThe National Institute for Health Research (NIHR) Yorkshire and Humber Patient Safety Translational Research Centre (NIHR Yorkshire and Humber PSTRC), Patient and Public Involvement and Engagement Research Fellow and NIHR Yorkshire and Humber PSTRC Patient Involvement in Patient Safety theme lay leader are involved in the preparation of a lay version of the findings within this manuscript.
Consultation with patients for whom English is not their native language
Authors: Ekladious Adel , Bhandari Ritesh , Sudusinghe Thilini N. , Jiang Beisi , Jahan Fahim 
Published: May 2023

AbstractGood communication with the patient is the cornerstone of effective and efficient consultation. The absence of a common language between the patient and physician negatively impacts the consultation outcome. Australia is a multicultural and multilingual country, with immigrants from all over the world. In the absence of a common language, it will be a challenging conversation affecting the patient's engagement with the healthcare system and poor treatment adherence. While involving an interpreter may help, it has its downsides and may not be ideal in all situations. Here, we discuss the experiences of various medical practitioners from different cultural and linguistic backgrounds (from Middle Eastern and Asian Countries) in managing non‐English‐speaking patients with a focus on the impacts of linguistic/cultural barriers in delivering optimal healthcare services and possible solutions to them.
CD83+ B cells alleviate uveitis through inhibiting DCs by sCD83
Authors: Feng Meng , Wang Xin , Zhou Shuping , Li Minghao , Liu Tingting , Wei Xunbin , Lin Wei 
Published: May 2023

AbstractSoluble CD83 (sCD83) exerts immunosuppressive functions in many autoimmune diseases, including experimental autoimmune uveitis (EAU), but the cells and mechanisms involved are unclear. This study showed that CD83+ B cells were the main sources of sCD83. They alleviated the symptoms of EAU and decreased the percentage of T cells and DCs in the eyes and lymph nodes. These CD83+ B cells decreased IL‐1β, IL‐18 and IFN‐γ secretion by DCs through sCD83. sCD83 interacted with GTPase Ras‐related protein (Rab1a) in DCs to promote Rab1a accumulation in autolysosomes and inhibit mTORC1 phosphorylation and NLRP3 expression. Hence, CD83+ B cells play a regulatory role in EAU by secreting sCD83. The lack of regulation of CD83+ B cells might be an important factor leading to hyperimmune activation in patients with autoimmune uveitis. CD83+ B cells suppress activated DCs in uveitis, indicating the potential therapeutic role of CD83+ B cells in uveitis.
The role of human resource management and governance in addressing bullying, burnout and the depersonalization of junior and senior psychiatric nurses in Saudi Arabia
Authors: Alharbi Jalal , Pont Suzanne , Tee SingWhat , Maxwell Stephen J. 
Published: May 2023

AbstractThis study examined the level of perceived responsibility junior and senior psychiatric nurses have for human resources and governance in Saudi Arabia. Bullying is a significant issue in nursing and an entrenched cultural practice that highlights a failure in governance and human resource responsibilities. A total of 90 responses (43.1%) to a 5‐point Likert Scale survey that sought respondent perceptions on leadership, governance and human resources. This study is reported using EQUATOR network recommendations (SQUIRE 2.0). This survey revealed that junior and senior nursing respondents weakly agree with all statements. Neither nurse rank, educational status nor nationality affected the answers of the respondents; there were age, gender and experience effects. There is a significant correlation between all responses to the statements implying there is a social desirability bias to the responses. If bullying, and its derived consequence of burnout, is to be addressed there needs to be a cultural shift in the attitudes of junior and senior nurses towards more acceptance of their HR and governance responsibilities. Furthermore, there needs to be an increased focus on shared leadership responsibilities, with greater nurse‐manager interaction and cooperation on transformational practices that will bring cultural change to the clinical space.
What is the prevalence of chronic venous disease among health care workers? A scoping review
Authors: Benn Sarah , Moore Zena , Patton Declan , O'Connor Tom , Nugent Linda , Harkin Denis , Avsar Pinar 
Published: May 2023

AbstractChronic venous disease (CVD) occurs because of structural or functional disturbances to the venous system of the lower limbs. Signs and symptoms include leg pain, swelling, varicose veins, and skin changes, with venous ulceration ultimately occurring in severe disease. To assess the prevalence of CVD among health care workers, a scoping review of existing publications exploring the prevalence of CVD among health care workers was conducted in July 2022. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines were used. A total of 15 papers met the inclusion criteria and these formed the basis of the review. Among health care workers, the mean prevalence of CVD was 58.5% and the mean prevalence for varicose veins was 22.1%. There is an increased prevalence of CVD in health care workers when compared with the general population. Therefore, there is a need for early diagnosis and the use of preventative measures to protect health care workers from CVD and varicose vein development.
Disruption of the left anterior ventrolateral temporal cortex along with the inferior longitudinal fasciculus impairs the ability to retrieve famous face names: Evidence from three longitudinal case studies
Authors: Burkhardt Eléonor , Lemaitre Anne‐Laure , Ng Sam , Moritz‐Gasser Sylvie , Hirsch Fabrice , Duffau Hugues , Herbet Guillaume 
Published: May 2023

AbstractThe cortical distribution of the proper name (PN) retrieval network has been widely studied contrary to its connectional anatomy. Here, we report the case of three patients with a low‐grade glioma damaging the mid‐to‐anterior part of the left temporal lobe. A longitudinal behavioural assessment showed that the surgery caused a long‐lasting decline in PN retrieval performances in all patients. Furthermore, a detailed analysis of surgery‐related structural disconnections revealed that interruption of the inferior longitudinal fasciculus was the unique common denominator.
Partial Klüver–Bucy syndrome in a Paediatric patient: A post‐neurosurgical and neuropsychological cases
Authors: Hernández‐Martínez Alejandra Estefanía , Serrano‐Juárez Carlos Alberto , Barrera‐Medellín Karen Grisel , Ramírez‐Quiroga Cecilia Inés , Ramírez‐Reyes Alma Griselda , Casarrubias Islas Roberto , Prieto‐Corona Belén 
Published: May 2023

AbstractA variety of cognitive, behavioural, and emotional impairments have been reported in the literature that are associated with the resection of the temporal cortex. Klüver–Bucy syndrome is one infrequently reported disorder in the paediatric population. This paper describes the neuropsychological findings of a female paediatric patient at 7 and 10 years of age with a diagnosis of partial Klüver–Bucy syndrome (pKBS) following total resection of the amygdala and right hippocampus to resect a glioma. The patient presented emotional problems, aggressiveness, hypermetamorphosis, social indifference, and behavioural dysexecutive syndrome, which was found at both 7 and 10 years, but with a decrease in the severity of alterations in attention, impulsivity, hyperactivity, and aggressive behaviour in a second evaluation after she had a neuropsychological intervention. These findings describe the neuropsychological profile of paediatric case with resection of the amygdala and right temporal lobe.