bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective comparison of percutaneous balloon compression and radiofrequency-thermocoagulation in the management of trigeminal neuralgia
Authors: Herta Johannes , Loidl Theresa Bettina , Schmied Tobias , Tomschik Matthias , Khalaveh Farjad , Wang Wei-Te , Dorfer Christian 
Published: June 2023

Abstract
Purpose
To compare percutaneous balloon compression (PBC) and radiofrequency thermocoagulation (RFTC) for the treatment of trigeminal neuralgia.

Methods
This was a retrospective single-center analysis of data from 230 patients with trigeminal neuralgia who underwent 202 PBC (46%) and 234 RFTC (54%) from 2002 to 2019. Comparison of demographic data and trigeminal neuralgia characteristics between procedures as well as assessment of 1) initial pain relief by an improved Barrow Neurological Institute (BNI) pain intensity scale of I–III; 2) recurrence-free survival of patients with a follow-up of at least 6 months by Kaplan-Meier analysis; 3) risk factors for failed initial pain relief and recurrence-free survival by regression analysis; and 4) complications and adverse events.

Results
Initial pain relief was achieved in 353 (84.2%) procedures and showed no significant difference between PBC (83.7%) and RFTC (84.9%). Patients who suffered from multiple sclerosis (odds ratio 5.34) or had a higher preoperative BNI (odds ratio 2.01) showed a higher risk of not becoming pain free. Recurrence-free survival in 283 procedures was longer for PBC (44%) with 481 days compared to RFTC (56%) with 421 days (p=0.036) but without statistical significance. The only factors that showed a significant influence on longer recurrence-free survival rates were a postoperative BNI ≤ II (P=<0.0001) and a BNI facial numbness score ≥ 3 (p = 0.009). The complication rate of 22.2% as well as zero mortality showed no difference between the two procedures (p=0.162).

Conclusion
Both percutaneous interventions led to a comparable initial pain relief and recurrence-free survival with a low and comparable probability of complications. An individualized approach, considering the advantages and disadvantages of each intervention, should guide the decision-making process. Prospective comparative trials are urgently needed.
Interactions of triazole terconazole with copper and zinc cations
Authors: Jaklová Dytrtová Jana , Kovač Ishak , Navrátil Tomáš , Jakl Michal 
Published: June 2023

AbstractTerconazole is one of the triazole derivatives with an antifungal effect. It is used locally to treat vaginal yeast infections. Terconazole could interact with copper cations in the vagina or uterus of women who use an intrauterine device releasing copper cations. Other triazole derivatives in complexes with copper cations differ in their properties like toxicity or mobility. Cu2+ can be reduced in the presence of triazoles, which can lead to a Fenton-like reaction and the production of free radicals. Thus, the Cu2+/Cu+ terconazole system can be potentially dangerous. Stoichiometry, fragmentation, and stability of forming complexes were studied with tandem mass spectrometry. The Cu2+/Cu+ terconazole system was measured within the pH range of 4.0–7.2, with a concentration ratio of CuCl2 and terconazole 1:5 to 20:1, with water and ethanol as solvents (1:1). The achieved results suggest that terconazole is partially oxidized in the Cu2+/terconazole system and that this oxidation depends on the pH of a solution. Apart from the oxidized and protonated terconazole, other detected ions and complexes were not significantly affected by pH. The detection of complexes containing Cu+ is alarming because this could correspond to the occurrence of a Fenton-like reaction.
Graphical abstract
Association between the antioxidant properties of SESN proteins and anti-cancer therapies
Authors: Kozak Joanna , Jonak Katarzyna 
Published: June 2023

AbstractSince the beginning of SESN protein development, they have attracted highly progressive attention due to their regulatory role in multiple signalling pathways. Through their antioxidant activity and autophagy regulation implication, they can function as powerful antioxidants to reduce oxidative stress in cells. SESN proteins received special attention in the field of regulation of reactive oxygen species level in the cell and its interplay with signalling pathways determining energy and nutrient homeostasis. Since perturbations in these pathways are implicated in cancer onset and development, SESNs might constitute potential novel therapeutic targets of broad interest. In this review, we discuss the impact of SESN proteins on anti-cancer therapy based on naturally occurring compounds and conventionally used drugs that influence oxidative stress and autophagy-induced cellular signalling pathways. The significant changes in reactive oxygen species level and nutrient status in cancer cells generate subsequent biological effect through the regulation of SESN-dependent pathways. Thus, SESN may serve as the key molecule for regulating anti-cancer drugs’ induced cellular response.
Assessment of predation risk through conspecific cues by anuran larvae
Authors: Caballero-Díaz Carlos , Arribas Rosa , Polo-Cavia Nuria 
Published: June 2023

AbstractAccurate assessment of predation risk is critical for prey survival during predator–prey interactions. Prey can assess predation risk by the presence of cues dropped by predators themselves, but they can also gather information about risk level through cues released by other prey, avoiding the hazard of being in close proximity to predators. In this study, we examine the ability of anuran larvae (Pelobates cultripes) to detect predation risk indirectly when they are in contact with conspecifics that have been recently exposed to chemical stimuli from natural predators (larvae of aquatic beetles). In a first experiment, we confirmed that larvae exposed to predator cues exhibited innate defensive behavior, indicating that they perceived the risk of predation and, thus, could potentially act as risk indicators for naïve conspecifics. In a second experiment, we observed that unexposed larvae paired with a startled conspecific adjusted their antipredator behavior, presumably by mirroring conspecifics’ behavior and/or using chemical cues from their partners as a risk information source. This cognitive ability of tadpoles to assess predation risk through conspecific cues might play an important role in their interaction with predators, facilitating the early detection of potential threats to elicit appropriate antipredator responses and increase the chances of survival.
End-to-end stapled technique for Kono-S anastomosis
Authors: Adams E. D. , Zaghiyan K. N. , Fleshner P. R. 
Published: June 2023

Abstract
Purpose
Our aim was to develop a Kono-S anastomotic technique using surgical staplers.

Methods
Two patients underwent stapled Kono-S anastomosis, one via abdominal and one transanal approach.

Results
The approach for an abdominal and transanal stapled Kono-S anastomosis is detailed.

Conclusion
The Kono-S anastomosis can be safely configured using common surgical staplers.
Multi-level predictors of being up-to-date with colorectal cancer screening
Authors: Lich Kristen Hassmiller , Mills Sarah D. , Kuo Tzy-Mey , Baggett Chris D. , Wheeler Stephanie B. 
Published: June 2023

Abstract
Purpose
Assessing factors associated with being up-to-date with colorectal cancer (CRC) screening is important for identifying populations for which targeted interventions may be needed.

Methods
This study used Medicare and private insurance claims data for residents of North Carolina to identify up-to-date status in the 10th year of continuous enrollment in the claims data and in available subsequent years. USPSTF guidelines were used to define up-to-date status for multiple recommended modalities. Area Health Resources Files provided geographic and health care service provider data at the county level. A generalized estimating equation logistic regression model was used to examine the association between individual- and county-level characteristics and being up-to-date with CRC screening.

Results
From 2012–2016, 75% of the sample (n = 274,660) age 59–75 was up-to-date. We identified several individual- (e.g., sex, age, insurance type, recent visit with a primary care provider, distance to nearest endoscopy facility, insurance type) and county-level (e.g., percentage of residents with a high school education, without insurance, and unemployed) predictors of being up-to-date. For example, individuals had higher odds of being up-to-date if they were age 73–75 as compared to age 59 [OR: 1.12 (1.09, 1.15)], and if living in counties with more primary care physicians [OR: 1.03 (1.01, 1.06)].

Conclusion
This study identified 12 individual- and county-level demographic characteristics related to being up-to-date with screening to inform how interventions may optimally be targeted.
Tuberculosis is associated with sputum metabolome variations, irrespective of patient sex or HIV status: an untargeted GCxGC-TOFMS study
Authors: Beukes Derylize , van Reenen Mari , Loots Du Toit , du Preez Ilse 
Published: June 2023

Abstract
Introduction
Various studies have identified TB-induced metabolome variations. However, in most of these studies, a large degree of variation exists between individual patients.

Objectives
To identify differential metabolites for TB, independent of patients’ sex or HIV status.

Methods
Untargeted GCxGC/TOF-MS analyses were applied to the sputum of 31 TB + and 197 TB- individuals. Univariate statistics were used to identify metabolites which are significantly different between TB + and TB- individuals (a) irrespective of HIV status, and (b) with a HIV + status. Comparisons a and b were repeated for (i) all participants, (ii) males only and (iii) females only.

Results
Twenty-one compounds were significantly different between the TB + and TB- individuals within the female subgroup (11% lipids; 10% carbohydrates; 1% amino acids, 5% other and 73% unannotated), and 6 within the male subgroup (20% lipids; 40% carbohydrates; 6% amino acids, 7% other and 27% unannotated). For the HIV + patients (TB + vs. TB-), a total of 125 compounds were significant within the female subgroup (16% lipids; 8% carbohydrates; 12% amino acids, 6% organic acids, 8% other and 50% unannotated), and 44 within the male subgroup (17% lipids; 2% carbohydrates; 14% amino acids related, 8% organic acids, 9% other and 50% unannotated). Only one annotated compound, 1-oleoyl lysophosphaditic acid, was consistently identified as a differential metabolite for TB, irrespective of sex or HIV status. The potential clinical application of this compound should be evaluated further.

Conclusions
Our findings highlight the importance of considering confounders in metabolomics studies in order to identify unambiguous disease biomarkers.
The Chebyshev center as an alternative to the analytic center in the feasibility pump
Authors: Baena Daniel , Castro Jordi 
Published: June 2023

AbstractAs a heuristic for obtaining feasible points of mixed integer linear problems, the feasibility pump (FP) generates two sequences of points: one of feasible solutions for the relaxed linear problem; and another of integer points obtained by rounding the linear solutions. In a previous work, the present authors proposed a variant of FP, named analytic center FP, which obtains integer solutions by rounding points in the segment between the linear solution and the analytic center of the polyhedron of the relaxed problem. This work introduces a new FP variant that replaces the analytic center with the Chebyshev center. Two of the benefits of using the Chebyshev center are: (i) it requires the solution of a linear optimization problem (unlike the analytic center, which involves a convex nonlinear optimization problem for its exact solution); and (ii) it is invariant to redundant constraints (unlike the analytic center, which may not be well centered within the polyhedron for problems with highly rank-deficient matrices). The computational results obtained with a set of more than 200 MIPLIB2003 and MIPLIB2010 instances show that the Chebyshev center FP is competitive and can serve as an alternative to other FP variants.
Herausforderungen beim Verfassen von Texten in der Sekundarstufe – Eine differenzielle Untersuchung nach Migrationshintergrund und Familiensprachen
Authors: Müller N. , Busse V. 
Published: June 2023

ZusammenfassungWährend die empirische Bildungsforschung literale Kompetenzen wie Lesen und Orthographie an weiterführenden Schulen recht umfassend in den Blick nimmt, gibt es vergleichsweise wenige Studien, die Texttiefenmerkmale untersuchen. Unser Beitrag analysiert instruktionale und argumentative Texte einer Stichprobe von Lernenden (N = 208) in Jahrgang 9 an nichtgymnasialen Schulformen und nimmt dabei differentielle Analysen nach Migrationshintergrund und Familiensprachen vor. Texttiefenmerkmale werden dabei mittels eines analytischen Diagnoseinstruments ausgewertet, das nach Struktur und Kohärenz unterscheidet. Ergänzend wird die Textqualität durch einen holistischen Vergleich der Texte (Comparative Judgement mit der Software Comproved®) bestimmt, zudem wurde die Textlänge erfasst. Hohe Korrelationen zwischen der analytischen Auswertung, dem holistischen Rating und der Textlänge bei insgesamt 415 Texten weisen darauf hin, dass Struktur und Kohärenz wichtige Aspekte der Textqualität sind. Die analytische Auswertung offenbart, dass im Bereich der Struktur fast alle Lernenden und im Bereich der Kohärenz etwa ein Drittel der Lernenden weniger als die Hälfte des theoretischen Maximums erreichen. Leistungsunterschiede zeigen sich nicht nur in den Bereichen Struktur und Kohärenz, sondern auch in der Auswertung der holistischen Textqualität sowie der Textlänge, zuungunsten von Lernenden mit Migrationshintergrund sowie insbesondere von Lernenden, die in der Familie ausschließlich andere Sprachen als Deutsch sprechen. Die Ergebnisse legen damit nahe, dass viele Lernende an nichtgymnasialen Schulformen besserer Unterstützung im Bereich der Texttiefenmerkmale bedürfen. Unser Diagnoseinstrument könnte im Sinne eines Assessment for Learning dabei helfen, auch schwächere Schreibende bei der Gestaltung von Struktur und Kohärenz zu unterstützen.
Educational integration by the third generation? Placement and academic achievement of students with immigrant background in Germany
Authors: Hunkler Christian , Schotte Kristin 
Published: June 2023

AbstractStudies show that minority students who were born abroad or whose parents were born abroad are less successful in school than their majority peers. However, little is known on whether these disadvantages persist for the grandchildren of immigrants, i.e., the third generation. Assimilation theories come to different predictions for third-generation students’ educational integration. We investigate third-generation students’ placement in different school types and their reading and mathematics achievements in Germany. Using data on ninth graders (N = 14,958) collected in the National Educational Panel Study enabled us to precisely identify third-generation students and to distinguish students by their ancestors’ countries of birth. Our results reveal that most third-generation students did not differ in their educational success from their majority peers, while first-generation and some groups of second-generation students, on average, were less successful in school. Overall, our findings are in line with classical and new assimilation theories and suggest that educational integration is mostly “completed” by the third generation in Germany. For some groups, however, we do not observe the major trends predicted by classical and new assimilation theories but patterns suggesting processes expected in segmented assimilation theory.
Endoscopic Diagnosis and Response Evaluation in Patients with Eosinophilic Esophagitis
Authors: Sorge Andrea , Masclee Gwen M. C. , Bredenoord Albert J. 
Published: June 2023

Abstract
Purpose of review
The aim of this review is to provide practical guidance for clinicians to support the optimal use of endoscopy in both the diagnosis and the evaluation of treatment response in patients with eosinophilic esophagitis (EoE).

Recent findings
The systematic and high-quality assessment and grading of EoE endoscopic features improves EoE detection. Fibrotic complications of EoE that negatively impact patients’ symptoms and quality of life can be detected and treated through endoscopy. The correlation between endoscopic features of EoE and histological activity remains challenging. However, assessment of endoscopic activity is fast and reliable in the evaluation of treatment response and, therefore, is supported by current guidelines. New modalities such as FLIP panometry and molecular markers for diagnosis and monitoring of EoE are promising, but whether they may replace endoscopy in guiding treatment of EoE needs to be ascertained.

Summary
Endoscopy plays a central role in EoE management, both in routine practice and in clinical trials. Endoscopy is pivotal in EoE diagnosis and response evaluation since it allows the direct assessment of endoscopic disease activity and, indirectly, the histological evaluation. Consequently, together with clinical and histological evaluation, endoscopy is rapidly becoming essential in monitoring the effectiveness of therapy in patients with EoE.
Particle flow simulation of Brazilian splitting failure characteristics of layered shale
Authors: Sun Feng , Huang Wei , Zhao Bingbing , Xue Shifeng , Zhou Bo 
Published: June 2023

AbstractShale reservoir is the research hotspot in the development of unconventional oil and gas resources. The properties of bedding plane have an important influence on the mechanical behavior of shale. According to the fracture characteristics of layered shale under Brazilian splitting load, the effects of bedding angle, bond strength ratio and natural fractures on the tensile strength and fracture pattern of layered shale in Brazilian splitting test were studied by particle flow code. The evolution mechanism of meso–macro fracture of shale is analyzed by combining the dynamic change process of particle mesoscopic force chain and crack. The results show that three types of fracture patterns are observed: splitting tensile failure of shale matrix, splitting tensile failure along bedding plane and tensile–shear composite failure along shale matrix and bedding plane. Mesoscopic cracks initiate at the top and bottom loading points of the disk. After the peak load, mesoscopic cracks propagate through and appear dense force chains until macroscopic failure occurs. The bond strength ratio of bedding plane affects the failure pattern and peak strength of the specimen. With the increase in bedding angle, the tensile strength decreases gradually. Considering the influence of natural fractures, the tensile strength of shale is lower, and the crack propagation is more complex. The research model and results provide theoretical basis for the mechanical properties evaluation and fracture pattern analysis of shale.
Fifteen research needs for understanding climate change impacts on ecosystems and society in the Norwegian High North
Authors: Kebir Zina , Chambers Catherine , Frainier André , Hausner Vera , Lennert Ann Eileen , Lento Jennifer , Poste Amanda , Ravolainen Virve , Renner Angelika H. H. , Thomas David N. , Waylen Kerry 
Published: June 2023

AbstractThere is an urgent need to understand and address the risks associated with a warming climate for ecosystems and societies in the Arctic and sub-Arctic regions. There are major gaps in our understanding of the complex effects of climate change—including extreme events, cascading impacts across ecosystems, and the underlying socioecological dynamics and feedbacks—all of which need collaborative efforts to be resolved. Here, we present results where climate scientists, ecologists, social scientists, and practitioners were asked to identify the most urgent research needs for understanding climate change impacts and to identify the actions for reducing future risks in catchment areas in the Norwegian High North, a region that encompasses both Arctic and sub-Arctic climates in northern Norway. From a list of 77 questions, our panel of 19 scientists and practitioners identified 15 research needs that should be urgently addressed. We particularly urge researchers to investigate cross-ecosystem impacts and the socioecological feedbacks that could amplify or reduce risks for society.
In vitro–in vivo assessments of apocynin-hybrid nanoparticle-based gel as an effective nanophytomedicine for treatment of rheumatoid arthritis
Authors: Aman Reham Mokhtar , Zaghloul Randa Ahmed , Elsaed Wael M. , Hashim Irhan Ibrahim Abu 
Published: June 2023

AbstractApocynin (APO), a well-known bioactive plant-based phenolic phytochemical with renowned anti-inflammatory and antioxidant pharmacological activities, has recently emerged as a specific nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) oxidase inhibitor. As far as we know, no information has been issued yet regarding its topical application as a nanostructured-based delivery system. Herein, APO-loaded Compritol® 888 ATO (lipid)/chitosan (polymer) hybrid nanoparticles (APO-loaded CPT/CS hybrid NPs) were successfully developed, characterized, and optimized, adopting a fully randomized design (32) with two independent active parameters (IAPs), namely, CPT amount (XA) and Pluronic® F-68 (PF-68) concentration (XB), at three levels. Further in vitro–ex vivo investigation of the optimized formulation was performed before its incorporation into a gel base matrix to prolong its residence time with consequent therapeutic efficacy enhancement. Subsequently, scrupulous ex vivo–in vivo evaluations of APO-hybrid NPs-based gel (containing the optimized formulation) to scout out its momentous activity as a topical nanostructured system for beneficial remedy of rheumatoid arthritis (RA) were performed. Imperatively, the results support an anticipated effectual therapeutic activity of the APO-hybrid NPs-based gel formulation against Complete Freund’s Adjuvant-induced rheumatoid arthritis (CFA-induced RA) in rats. In conclusion, APO-hybrid NPs-based gel could be considered a promising topical nanostructured system to break new ground for phytopharmaceutical medical involvement in inflammatory-dependent ailments.

Graphical Abstract
Investigation of adsorption kinetics and isothermal thermodynamics for optimizing methylene blue adsorption onto a modified clay with cellulose using the response surface approach
Authors: Hamidi Abderrazak , Atia Djamal , Rebiai Abdelkrim , Reghioua Abdallah , Zobeidi Ammar , Messaoudi Mohammad , Seghir Bachir Ben , Pohl Pawel , Simal-Gandara Jesus 
Published: June 2023

Abstract
In this study, the clay was interwoven with cellulose to change its structure. The product clay/cellulose was used to assess the efficacy of the methylene blue (MB) dye removal from aqueous solutions (CC25). The response surface methodology and Box-Behnken design were used to optimize the influence of crucial parameters (cellulose load, adsorbent dosage, solution pH, temperature, and contact duration) (RSM-BBD). The greatest removal effectiveness was 98.76% for a cellulose loading of 25.0% and the following working conditions, i.e., adsorbent dosage of 0.06 g/L, pH 7, temperature of 45 °C, and contact length of 20 min. At the time, the maximum adsorption capacity was 254.8 mg/g. The pseudo-second-order adsorption model, according to the adsorption kinetics research, was used to describe the process. The MB adsorption process was endothermic and spontaneous, according to computed thermodynamic functions. The developed composite material, according to our results, has a very high capacity for the color absorption and removal.