bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental Health Care Seeking Behavior in Bangladesh: Evidence from the National Mental Health Survey 2019
Authors: Huque Rumana , Azad Abul Kalam , Islam Khaleda , Ahmed Helal Uddin , Amin Md. Robed 
Published: April 2023

Abstract
Objectives The study aims to explore the existing pattern of mental healthcare-seeking behavior among the adult population in Bangladesh, and to delineate the factors that influence the mental health patients' decision to receive mental healthcare services.Methods We used the National Mental Health Survey Bangladesh 2019 dataset with 7270 households to identify the patterns and catalysts of seeking mental health care services. A Probit model using a standard normal cumulative distribution function (CDF) with three specifications has been applied to identify the factors influencing mental healthcare-seeking behavior and the probability of seeking mental healthcare services in Bangladesh.Results We found that about 19% of the total adult population have mental health disorder in the country. Among the mental health disorder patients, only 10% seek healthcare services from different sources of mental healthcare services. Patients with addictive disorder show the lowest interest in seeking healthcare services, while patients with bipolar-related disorder receive treatment from mental healthcare sources. Findings portray that 4.8% of addictive disorder patients seek healthcare services. On the other hand, 34.4% of bipolar-related disorder patients receive treatment for mental health. In addition, the findings from the Probit model show that only the existence of other mentally disordered family members is the only statistically significant determinant among the socio-economic factors, such as gender, age, religion, education level and residential status. The marginal effects analysis shows that the existence of mentally disordered family members increases the probability of seeking mental health care services by around 6%. The other socio-economic variables considered in the study are found statistically insignificant. However, a married woman has a significantly higher likelihood of seeking treatment than an unmarried woman, while the family size is the only variable that significantly influences treatment-seeking behavior for men.Conclusion Though mental health conditions are major public health concerns in Bangladesh, the treatment-seeking behavior among the mentally diorder people is very low, implying a large treatment gap in the mental health sector. The findings indicate the urgent need to increase mental health service coverage among mental health patients.
The Relationship Between College Students' Sense of Social Connection and Insomnia during the COVID-19 Lockdown in China：A Moderated Mediation Model
Authors: Liu Quzhi , Jiang Xiuya , Zhang Shuo 
Published: April 2023

Abstract
The lockdown due to the coronavirus pandemic may have exacerbated mental health problems. This study aimed to explore the mediating and moderating effects of rumination and exercise between social connectedness and insomnia. A cross sectional survey was employed, a total of 10097 Chinese students completed social connectedness (SCS-R), total active time (IPAQ-SF), rumination and insomnia severity (ISI). The results revealed that: (1) social connectedness had a significant direct predictive effect on insomnia in college students (β = -0.19, t=-48.31, p<0.01), can also indirectly predict the level of insomnia through the mediation of rumination (β = -0.13, t = -32.41, p<0.01). (2) The direct effect of social connectedness on insomnia and the mediating effect of rumination were moderated by exercise. This study supports the view that insomnia may be aggravated during lockdown, which was associated with a decreased sense of social connectedness.
Infrared initiation of frontal polymerization with density gradient multi-layered resins for tunable colored layers via photothermal effect
Authors: Wi Eunsoo , Kim Younghun 
Published: April 2023

Abstract
Frontal polymerization (FP) is a unique polymerization technique that involves the self-propagation of heat, which is triggered by a local heat source, such as a photoinitiator. In this paper, we propose a novel method for producing colorful polymeric layers through an FP reaction using carbon black (CB) under near-infrared (NIR) irradiation. In the FP reaction, CB and dicyclopentadiene (DCPD) were used as the photothermal agent and monomer, respectively. The photothermal efficiencies of the CB/DCPD suspensions were found to increase with the increase in their CB content. After photothermal initiation, the exothermic FP reaction propagated thermally, resulting in the formation of a free-standing poly(DCPD) resin. In addition, the density of the DCPD suspension in the test tube was adjusted to prepare a multilayered, colored poly(DCPD) resin. Consequently, a four-colored poly(DCPD) resin was obtained via an NIR-induced FP reaction. These results indicate that nanosized CB can be an effective photothermal agent for FP and that the proposed approach can be used for the rapid curing of polymers with multicolored layers with low energy consumption.
Minimally invasive techniques for lateral maxillary sinus floor elevation: small lateral window and one-stage surgery—A 2- to 5-year retrospective study
Authors: Cai Xiaoxiao , Gao Shaojingya , Jiang Yao , Yao Yangxue , Li Songhang 
Published: April 2023

Abstract
This study aimed to introduce a minimally invasive technique for maxillary sinus floor elevation using the lateral approach (lSFE) and to determine the factors that influence the stability of the grafted area in the sinus cavity. Thirty patients (30 implants) treated with lSFE using minimally invasive techniques from 2015 to 2019 were included in the study. Five aspects of the implant (central, mesial, distal, buccal, and palatal bone heights [BHs]) were measured using cone-beam computed tomography (CBCT) before implant surgery, immediately after surgery (T0), 6 months after surgery (T1), and at the last follow-up visit (T2). Patient characteristics were collected. A small bone window (height, 4.40 ± 0.74 mm; length, 6.26 ± 1.03 mm) was prepared. No implant failed during the follow-up period (3.67 ± 1.75 years). Three of the 30 implants exhibited perforations. Changes in BH, defined as the distance between the implant platform level and the uppermost level of bone graft, of the five aspects of implants showed strong correlations with each other and decreased dramatically before second-stage surgery. RBH did not significantly influence BH changes, whereas smoking status and type of bone graft material were potentially influential factors. During the 3-year observation period, lSFE with a minimally invasive technique demonstrated high implant survival and limited bone reduction in grafted area. In conclusion, patients who were nonsmoker and whose sinus cavity was filled with deproteinized bovine bone mineral (DBBM) had significantly limited bone resorption in grafted area.
Multi-omics data integration analysis of prostate cancer based on sparse least partial squares regression algorithm based on hypergraph regularization
Authors: Huang Ruo-Hui , Ge Zi-Lu , Xu Gang , Zeng Qing-Ming , Jiang Bo , Xiao Guan-Cheng , Xia Wei , Wu Yu-ting , Liao Yun-feng 
Published: April 2023

Abstract
Prostate cancer (PCa) is a malignant tumor of the male reproductive system, and its incidence has increased significantly in recent years. This study aimed to further identify candidate biomarkers with prognostic and diagnostic significance by integrating gene expression and DNA methylation data from PCa patients through association analysis. To this end, this paper proposes a sparse partial least squares regression algorithm based on hypergraph regularization (HR-SPLS) by integrating and clustering two kinds of data. Next, module 2, with the most significant weight, was selected for further analysis according to the weight of each module related to DNA methylation and mRNAs. Based on the DNA methylation sites in module 2, this paper uses multiple machine learning methods to construct a PCa diagnosis-related model of 10-DNA methylation sites. The results of ROC analysis showed that the DNA methylation-related diagnostic model we constructed could diagnose PCa patients with high accuracy. Subsequently, based on the mRNAs in module 2, we constructed a prognostic model for 7-mRNAs (MYH11, ACTG2, DDR2, CDC42EP3, MARCKSL1, LMOD1, and MYLK) using multivariate Cox regression analysis. The prognostic model could predict the disease free survival of PCa patients with moderate to high accuracy (AUC=0.761). In addition, GSEA and immune analysis indicated that the prognosis of patients in the risk group might be related to immune cell infiltration. Our findings may provide new methods and insights for identifying disease-related biomarkers by integrating DNA methylation and gene expression data.
Response of the corneal surface changes after stromal lenticule addition keratoplasty combined with cross-linking for keratoconus
Authors: Sun Xiyu , Shen Di , Wang Yani , Wang Rui , Wei Wei 
Published: April 2023

Abstract

BACKGROUND Corneal crosslinking (CXL) is used to stabilize corneas with a central thickness greater than 400 µm. In patients with more advanced keratoconus, traditional corneal transplantation may be required. In this study, we described the response of the anterior and posterior corneal surface in femtosecond laser-assisted convex stromal lenticule addition keratoplasty (SLAK) combined with CXL for treating keratoconus.METHODS Twenty eyes of 20 keratoconus patients who underwent SLAK combined with CXL were included. The morphological indices in terms of keratometry and elevation data were recorded from the Sirius at baseline and at 1 and 3 months postoperatively. The mean values of maximum keratometry (Kmax), flat keratometry (K1), and steep keratometry (K2) at central, 3-mm, 5-mm, and 7-mm area was measured from the curvature map. The change in anterior and posterior corneal elevation under the best-fit sphere (BFS) radius at seven points horizontally of the center, 3-mm, 5-mm, and 7-mm area from the center at both Nasal(N) and Temporal(T) side were measured from elevation map.RESULTS For the front corneal curvature, Kmax, K1, and K2 at 3-mm, 5-mm, and 7-mm of the anterior corneal surface increased significantly 1 month postoperatively (all P < 0.05) and remained unchanged until 3 months(P > 0.05). For the back corneal curvature, K1 and K2 along the 3-mm back meridian significantly decreased after month 1 (P = 0.002, 0.077, respectively). Posterior K-readings along the 5-mm and 7-mm did not change after surgery(P > 0.05). Anterior BFS decreased 1 month(P < 0.001) postoperatively but remained unchanged until 3 months after SLAK(P > 0.05). No change was found in posterior BFS before and after the surgery(P > 0.05). Anterior elevation at N5, N3, central, and T5 points and posterior elevation at central and T7 points shifted backward 1 month postoperatively (all P < 0.05) and remained stable until 3 months(P < 0.05).CONCLUSIONS The myopic SLAK combined with CXL is an economical alternative for stabilizing the corneal surface in severe keratoconus. "Pseudoprogression" occurs in the early phase postoperatively, but it was not an indicator of keratoconus progression. Anterior and posterior elevation underwent slight backward displacement after the surgery.
Emergence of periodic circumferential actin cables from the anisotropic fusion of actin nanoclusters during tubulogenesis
Authors: Sekine Sayaka , Tarama Mitsusuke , Wada Housei , Sami Mustafa , Shibata Tatsuo , Hayashi Shigeo 
Published: April 2023

Abstract
The periodic circumferential cytoskeleton supports various tubular tissues1-5. Radial expansion of the tube lumen causes anisotropic tensile stress, which can be exploited as a geometric cue6. However, the molecular machinery linking anisotropy to robust circumferential patterning is poorly understood. Here, we aimed to reveal the emergent process of circumferential actin cable formation in a Drosophila tracheal tube7. During luminal expansion, sporadic actin nanoclusters emerge and exhibit circumferentially biased motion and fusion. RNAi screening revealed the formin family protein, DAAM, as an essential component of tensile stress sensing, and non-muscle myosin II as a component required for nanocluster fusion. A coarse-grained molecular dynamics simulation demonstrated that crosslinkers play a crucial role in nanocluster formation and cluster-to-cable transition occurs in response to mechanical anisotropy. Altogether, we propose that an actin nanocluster is an organizational unit that senses stress in the cortical membrane and builds a higher-order cable structure.
Clinical Pharmacy in the ICU: A Qualitative View of Healthcare Professionals
Authors: Nascimento Diego Zapelini do , Marques Gabriela Moreno , Vieira Janete Leite , Soares Alessandra de Sá , Schuelter-Trevisol Fabiana 
Published: April 2023

Abstract
Objective: To evaluate the opinion of professionals working in intensive care units (ICU) regarding expectations of the Clinical Pharmacy service.
Methods: Data were obtained by the focus group technique and interpreted by content analysis. The group included one physician, two nurses, one nutritionist, one physiotherapist and ten pharmacists. The discussions were led by a psychologist, in which the participants were asked to consider aspects about their experience and professional life in relation to the Intensive Care Clinical Pharmacy service.
Results: Analysis of the discussion resulted in four different themes: Activities pertinent to the hospital clinical pharmacist in the Brazilian reality; Existing difficulties in the development of pharmaceutical assistance in ICU; The expectations of the work team regarding the performance of the intensive care clinical pharmacist and Improvements in the provision of the Intensive Care Clinical Pharmacy service. The multidisciplinary team and the clinical pharmacists see the Clinical Pharmacy service as vital for critically ill patients and as a guarantee of patient safety, but they question to what extent communication between the pharmacist and other professionals is adequate, as well as whether undergraduate and graduate courses prepare pharmacists to assist in decisions about patients.
Conclusion: Through this research, pertinent questions were raised to be discussed in the literature and analyzed in future studies regarding the perceptions of health professionals, including pharmacists, considering the current moment of modification in the process of providing the Clinical Pharmacy service in Brazil.
Ovotesticular disorder 46, XY: A rare case report with review of the literature
Authors: BBS KOUI , AD ABOUNA , T DJIWA , B TRAORE , M KOUYATE , KE KOUAME , NA AMAN 
Published: April 2023

Abstract
Introduction

Ovotestis is a rare cause of sexual ambiguity characterized by the presence in a patient of both testicular and ovarian tissue, leading to the development of both male and female structures. We report a case of ovotestis diagnosed in an adolescent, with a review of the literature.

Case Report

A 15-year-old patient presented with a right scrotal swelling associated with gynecomastia. Histology showed a juxtaposition of ovarian stroma and seminiferous tubules. Karyotype revealed a male subject (XY).

Conclusion

Ovotestis is a rare finding, heterogeneous in its genetic etiology and clinical presentation. While many patients are diagnosed during infancy or childhood, we presented a case diagnosed in a 15-year-old adolescent.
The novel investigation to Fornberg-Whitham equation via fractional natural transform decomposition method
Authors: Anaç Halil 
Published: April 2023

Abstract
The aim of this study is to use the fractional natural transform decomposition method to numerically solve time-fractional partial differential equations. Fractional derivatives are Caputo sense. FNTDM is also used to examine applications, and the solutions obtained by this method have been compared to those obtained by the variational iteration method, fractional variational iteration method, and homotopy perturbation method. In addition, the MAPLE package draws graphs of the solutions of nonlinear time-fractional partial differential equations, taking into account physics.
Mathematics Subject Classification 35R11 - 35C05 - 65R10
Study on reservoir optimal operation based on coupled adap-tive ε constraint and multi strategy improved Pelican algo-rithm
Authors: He Ji , Guo Xiaoqi , Wang Songlin , Chen Haitao , Chai Fuxin 
Published: April 2023

Abstract
The optimal operation of reservoir group is a multi-constrained and high-dimensional optimization problem. For this problem, this paper couples the standard pelican optimization algorithm with the adaptive ε-constraint method, and further improves the algorithm's optimization-seeking perfor-mance through the good point set initialization population, reverse differential evolution and op-timal individual adaptive strategy, and proposes an improved pelican algorithm (ε-IPOA) based on the adaptive ε method. The performance of the algorithm is tested by eight constraint test functions to find the optimal ability and solve the constrained optimization problem, and the results show that the algorithm has a strong ability to find the optimal and stable performance. In this paper, we select Sanmenxia and Xiaolangdi reservoirs as the research objects, establish the maximum peak-cutting model of terrace reservoirs, apply the ε-IPOA algorithm to solve the model, and compare it with the ε-POA and ε-DE algorithms, the results show that the ε-IPOA algorithm is better than other algo-rithms, the peak clipping rate of Huayuankou control point solved by ε-IPOA algorithm reached 44%, and other algorithms do not find effective solutions meeting the constraint conditions. This paper provides a new idea for solving the problem of flood control optimal operation of cascade reservoirs.
Endovascular and microsurgical management of blister aneurysms: a multi-centre review
Authors: Reidy Joseph , Faulder Kenneth , Davidson Keryn , Harrington Timothy , Steinfort Brendan , Assaad Nazih , Dexter Mark , Ma Alice 
Published: April 2023

Abstract
Background Blister aneurysms (BA) are high risk cerebrovascular lesions accounting for 1% of intracranial aneurysms. The defective vessel wall and broad-based neck make this clinical entity difficult to treat, with high rates of re-rupture and mortality in patients presenting with acute subarachnoid haemorrhage. Blister aneurysms pose substantial challenges for both endovascular and microsurgical management.Objective To evaluate endovascular and microsurgical outcomes in intracranial blister aneurysm management across two tertiary hospitals.Methods A review of two tertiary hospitals with a systematic imaging database search for term of “blister” in modalities from January 2010 to October 2022. Operation reports were screened for the 5-year period since cerebral angiogram reports transitioned to surgical database. Identified reports were screened and reviewed for confirmed diagnosis by consultant neuroradiologist.Results 21 cases of blister aneurysms managed at respective facilities were included. 16 cases (76%) were managed endovascularly – all with flow diversion stents. 4 cases (19%) were managed surgically – 2 with primary clipping, and 2 wrap and clipping. 1 case was managed conservatively (5%). Clinical outcomes were discharge disposition, aneurysm exclusion and post-operative complications.Conclusion BAs have challenging considerations with high mortality and morbidity. Endovascular treatment is less invasive option with lower rates of intraoperative rupture and mortality. Patients discharged home were comparable. Commencement of dual anti-platelet therapy was safe in patients with flow diversion stents despite sub-arachnoid blood volume. Management of blister aneurysms is complex. Endovascular treatment shows promise for acute treatment but careful consideration of antithrombotic regime and requirement for further surgery should be considered.
The sequence of the 2017-2018 eruptions at Kirishima volcano group
Authors: Ichihara Mie , Kobayashi Tsukasa , Maeno Fukashi , Ohminato Takao , Watanabe Atsushi , Nakada Setsuya , Kaneko Takayuki 
Published: April 2023

Abstract
Kirishima volcano consists of more than 20 eruptive centers. Among them, Shinmoe-dake had magmatic eruptions in October 2017 and March 2018. Subsequently, another active cone, Iwo-yama, had phreatic eruptions in April 2018. These events were unique in that the 2018 eruption was the first effusion-dominated eruption of Shinmoe-dake and the first simultaneous activity of two cones of the Kirishima volcanic group ever documented. We report the detailed sequence of the events by combining areal photos, satellite images, and seismo-acoustic data analyses with the other published information. The seismo-acoustic data clarify the eruption onset and the transitions of the behaviors in three stages for each of the 2017 and 2018 eruptions. For both eruptions, we present regularly repeated tremors or 'drumbeat' earthquakes in the second stage, which interpret as gas separation from magma, leading to the ash-poor plume in the 2017 eruption or the effusive eruption in the 2018 event. We also propose that the 2017 and 2018 eruptions of Shinmoe-dake and the 2018 eruption of Iwo-yama are sequential events linked by the degassing of magma beneath Shinmoe-dake. An eruption like the 2017--2018 eruptions of Shinmoe-dake would leave little geological record and could be captured only by modern techniques. Although Shinmoe-dake has been believed to be an example of less-frequent eruptions, effusive eruptions like the 2018 case might have occurred more frequently in the past. The timelines summarized in this study will be useful in future studies of Kirishima volcanoes and world equivalences.
Reconstructing Spatial Transcriptomes with Graph-guided Neural Tensor Decomposition Informed by Spatial and Functional Relations
Authors: Kuang Rui , Song Tianci , Broadbent Charles 
Published: April 2023

Abstract
Spatially-resolved RNA profiling has now been widely used to understand cells' structural organizations and functional roles in tissues, yet it is a challenge to reconstruct the whole spatial transcriptomes due to various inherent technical limitations in tissue section preparation and RNA capture and fixation in the application of the spatial RNA profiling technologies. Here, we introduce a graph-guided neural tensor decomposition (GNTD) model for reconstructing whole spatial transcriptomes in tissues. GNTD employs tensor structures and formulations to explicitly model the high-order spatial gene expression data with a hierarchical non-linear decomposition in a three-layer neural network, enhanced by spatial relations among the capture spots and gene functional relations for accurate reconstruction from highly sparse spatial profiling data. Extensive experiments on 22 Visium spatial transcriptomics datasets and 3 high-resolution Stereo-seq datasets as well as simulation data demonstrate that GNTD consistently improves the imputation accuracy in cross-validations driven by non-linear tensor decomposition and incorporation of spatial and functional information, and confirm that the imputed spatial transcriptomes provide a more complete gene expression landscape for downstream analyses of cell/spot clustering for tissue segmentation, and spatial gene expression clustering and visualizations.