bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutritional status and associated factors among the elderly in Guinea: a first national cross-sectional study
Authors: Millimono Thierno Mamadou , Camara Alioune , Mabiama Gustave , Daffé Mamady , Boumédiène Farid , Preux Pierre-Marie , Desport Jean-Claude , Fayemendy Philippe , Jésus Pierre 
Published: September 2023

AbstractAging of the Guinean population is a public health concern for the coming years, and the nutritional status of older people is virtually unknown. We also know that this population is growing and that undernutrition and obesity can affect the health of older adults. This study aimed to assess the nutritional status of older people in the general population of Guinea and its associated factors. A representative cross-sectional survey was conducted using sociodemographic, clinical, and anthropometric data (weight and height). Oral status was assessed by using the University of Nebraska Oral Status Scale. Visual acuity was assessed using the Monoyer scale. The standardized prevalence ratio (SPR) of the nutritional status was calculated for each region. The sample included 1698 subjects with a mean BMI of 22.6 ± 4.3 kg/m2. A total of 50.3% had impaired oral status and 20.3% had moderately to severely impaired visual acuity. The prevalence of undernutrition was 14.4% and of obesity 5.7%. Differences in the prevalence of nutritional status were found between regions, with an SPR > 1 for undernutrition in the Labé region (SPR 1.9, 95% CI = 1.5–2.5) and for obesity in the Conakry and Kindia regions (SPR of 2.90, 95% CI = 2.0–4.05 and 2.32, 95% CI = 1.5–3.3, respectively). In Guinea, The prevalence of nutritional disorders was approximately 20%. Screening and management of the health and nutritional status of older adults should be a national priority, and management should be adapted to each region of the country.
Health benefits from risk information of air pollution in China
Authors: Wang Zhaohua , Liu Jie , Wang Bo , Zhang Bin , Deng Nana 
Published: September 2023

AbstractRisk-related information regarding air pollution can help people understand the risk involved and take preventive measures to reduce health loss. However, the health benefits through these protective behaviors and the health threat of information inequality have not been systematically measured. This article reports the health gains and losses caused by the interaction of “air pollution—air pollution information—human”, and studies the heterogeneity and impact of this interaction. Based on field investigations and transfer learning algorism, this study compiled the first nationwide city-level risk-related information (ERI) response parameter set in China. Then, we developed a Information-Behavioral Equivalent PM2.5 Exposure Model (I-BEPEM) model to project the health benefits caused by the impact of environmental risk-related information on residents’ protective behaviors under different scenarios. The protective behavior led by air pollution risk information reduces 5.7% PM2.5-related premature deaths per year. With a 1% increase in regional ERI reception, PM2.5-related premature mortality decreases by 0.1% on average; If the level of information perception and behavioral protection in all cities is the same as that in Beijing, PM2.5-related premature deaths will decrease by 6.9% annually in China. Further, changing the air quality standard issued by China to the American standard can reduce the overall PM2.5-related premature deaths by 9.9%. Meanwhile, compared with men, other age groups and rural residents, women, older persons, and urban residents are more likely to conceive risk information and adopt protective behaviors to reduce the risk of premature death from air pollution. Air pollution risk information can significantly reduce people's health loss. Changing the real-time air quality monitoring information indicator standard to a more stringent level can quickly and effectively enhance this effect. However, the uneven distribution of this information in regions and populations has resulted in the inequality of health gains and losses.
Entropy generation optimization for the electroosmotic MHD fluid flow over the curved stenosis artery in the presence of thrombosis
Authors: Sharma Bhupendra K. , Khanduri Umesh , Mishra Nidhish K. , Albaijan Ibrahim , Pérez Laura M. 
Published: September 2023

AbstractThe present study deals with the entropy generation analysis on the flow of an electrically conductive fluid (Blood) with $$\hbox {Al}_2\hbox {O}_3$$

Al
2

O
3

-suspended nanoparticles through the irregular stenosed artery with thrombosis on the catheter. The fluid flow can be actuated by the interactions of different physical phenomena like electroosmosis, radiation, Joule heating and a uniform radial magnetic field. The analysis of different shapes and sizes of the nanoparticle is considered by taking the Crocine model. The velocity, temperature, and concentration distributions are computed using the Crank–Nicholson method within the framework of the Debye–Huckel linearization approximation. In order to see how blood flow changes in response to different parameters, the velocity contour is calculated. The aluminium oxide nanoparticles employed in this research have several potential uses in biomedicine and biosensing. The surface’s stability, biocompatibility, and reactivity may be enhanced by surface engineering, making the material effective for deoxyribonucleic acid sensing. It may be deduced that the velocity profile reduces as the nanoparticle’s size grows while depicts the reverse trend for the shape size. In a region close to the walls, the entropy profile decreases, while in the region in the middle, it rises as the magnetic field parameter rises. The present endeavour can be beneficial in biomedical sciences in designing better biomedical devices and gaining insight into the hemodynamic flow for treatment modalities.
Understanding the effect of heat stress during seed filling on nutritional composition and seed yield in chickpea (Cicer arietinum L.)
Authors: Devi Poonam , Awasthi Rashmi , Jha Uday , Sharma Kamal Dev , Prasad P. V. Vara , Siddique Kadambot H. M. , Roorkiwal Manish , Nayyar Harsh 
Published: September 2023

AbstractIncreasing temperature affects all food crops, thereby reducing their yield potential. Chickpea is a cool-season food legume vital for its nutritive value, but it is sensitive to high temperatures (> 32/20 °C maximum/minimum) during its reproductive and seed-filling stages. This study evaluated the effects of heat stress on yield and qualitative traits of chickpea seeds in a controlled environment. Chickpea genotypes differing in heat sensitivity [two heat-tolerant (HT) and two heat-sensitive (HS)] were raised in pots, initially in an outdoor environment (average 23.5/9.9 °C maximum/minimum), until the beginning of pod set (107–110 days after sowing). At this stage, the plants were moved to a controlled environment in the growth chamber to impose heat stress (32/20 °C) at the seed-filling stage, while maintaining a set of control plants at 25/15 °C. The leaves of heat-stressed plants of the HT and HS genotypes showed considerable membrane damage, altered stomatal conductance, and reduced leaf water content, chlorophyll content, chlorophyll fluorescence, and photosynthetic ability (RuBisCo, sucrose phosphate synthase, and sucrose activities) relative to their corresponding controls. Seed filling duration and seed rate drastically decreased in heat-stressed plants of the HT and HS genotypes, severely reducing seed weight plant–1 and single seed weight, especially in the HS genotypes. Yield-related traits, such as pod number, seed number, and harvest index, noticeably decreased in heat-stressed plants and more so in the HS genotypes. Seed components, such as starch, proteins, fats, minerals (Ca, P, and Fe), and storage proteins (albumin, globulins, glutelin, and prolamins), drastically declined, resulting in poor-quality seeds, particularly in the HS genotypes. These findings revealed that heat stress significantly reduced leaf sucrose production, affecting the accumulation of various seed constituents, and leading to poor nutritional quality. The HT genotypes were less affected than the HS genotypes because of the greater stability of their leaf water status and photosynthetic ability, contributing to better yield and seed quality traits in a heat-stressed environment.
Malicious traffic detection on sampled network flow data with novelty-detection-based models
Authors: Campazas-Vega Adrián , Crespo-Martínez Ignacio Samuel , Guerrero-Higueras Ángel Manuel , Álvarez-Aparicio Claudia , Matellán Vicente , Fernández-Llamas Camino 
Published: September 2023

AbstractCyber-attacks are a major problem for users, businesses, and institutions. Classical anomaly detection techniques can detect malicious traffic generated in a cyber-attack by analyzing individual network packets. However, routers that manage large traffic loads can only examine some packets. These devices often use lightweight flow-based protocols to collect network statistics. Analyzing flow data also allows for detecting malicious network traffic. But even gathering flow data has a high computational cost, so routers usually apply a sampling rate to generate flows. This sampling reduces the computational load on routers, but much information is lost. This work aims to demonstrate that malicious traffic can be detected even on flow data collected with a sampling rate of 1 out of 1,000 packets. To do so, we evaluate anomaly-detection-based models using synthetic sampled flow data and actual sampled flow data from RedCAYLE, the Castilla y León regional subnet of the Spanish academic and research network. The results presented show that detection of malicious traffic on sampled flow data is possible using novelty-detection-based models with a high accuracy score and a low false alarm rate.
Towards a promising systematic approach to the synthesis of CZTS solar cells
Authors: Najm A. S. , Al-Ghamdi Azza , Amin Majdi T. , Al Ghamdi Ahmed , Moria Hazim , Holi Araa Mebdir , Abed Azher M. , AL-Zahrani Asla Abdullah , Sopian K. , Bais Badariah , Sultan Abbas J. 
Published: September 2023

AbstractThis study aims to enhance the CZTS device's overall efficiency, the key research area has been identified in this study is to explore the effects of a novel, low-cost, and simplified, deposition method to improve the optoelectronic properties of the buffer layer in the fabrication of CZTS thin film solar cells. Herein, an effective way of addressing this challenge is through adjusting the absorbers' structure by the concept of doping, sensitized CdS thin film by the bi-functional linker, and an environmentally friendly catalytic green agent. The Linker Assisted and Chemical Bath Deposition (LA-CBD) method was introduced as an innovative and effective hybrid sensitization approach. In the one-step synthesis process, Salvia dye, Ag, and 3-Mercaptopropionic acid (MPA) were used. Generally, the results for all samples displayed varying bandgap as achieved between (2.21–2.46) eV, hexagonal structure with considerably decreased strain level, broader grain size, and dramatically enhanced crystalline property. Hence, the rudimentary CdS/CZTS solar cell devices were fabricated for the application of these novel CdS films. Preliminary CZTS thin film solar cell fabrication results in the highest conversion efficiency of 0.266% obtained CdS + Salvia dye, indicating the potential use of the CdS films as a buffer layer for CZTS photovoltaic devices.
Phantom touch illusion, an unexpected phenomenological effect of tactile gating in the absence of tactile stimulation
Authors: Pilacinski Artur , Metzler Marita , Klaes Christian 
Published: September 2023

AbstractWe report the presence of a tingling sensation perceived during self-touch without physical stimulation. We used immersive virtual reality scenarios in which subjects touched their body using a virtual object. This touch resulted in a tingling sensation corresponding to the location touched on the virtual body. We called it “phantom touch illusion” (PTI). Interestingly, the illusion was also reported when subjects touched invisible (inferred) parts of their limb. We reason that this PTI results from tactile gating process during self-touch if there is no tactile input to supress. The reported PTI when touching invisible body parts indicates that tactile gating is not exclusively based on vision, but rather on multi-sensory, top-down input involving body schema. This supplementary finding shows that representations of one's own body are defined top-down, beyond the available sensory information.
The long-term impact of the COVID-19 pandemic on physical fitness in young adults: a historical control study
Authors: Ripley-Gonzalez Jeffrey W. , Zhou Nanjiang , Zeng Tanghao , You Baiyang , Zhang Wenliang , Liu Jie , Dong Yuchen , Guo Ying , Dun Yaoshan , Liu Suixin 
Published: September 2023

AbstractThe strength of evidence regarding long-term changes to fitness resulting from the coronavirus disease 2019 (COVID-19) lockdowns is deficient. This two-site retrospective study aimed to investigate the long-term changes in physical fitness among young adults a year after the onset of the pandemic using a robust historical control. University freshmen who underwent physical fitness tests in 2019 and completed a follow-up in 2020 (study group) were included. The primary focus was to compare the current cohort with a historical control group who completed the same tests a year prior (2018). A total of 5376 individuals were recruited, of which 2239 were in the study group. Compared with the control, the study group exhibited a decrease in anaerobic fitness, with an overall difference of −0.84 (95% confidence interval [CI], [−1.33 to −0.36]); declines in aerobic fitness, with a difference of −2.25 [−3.92 to −0.57] for males and −4.28 [−4.97 to −3.59] for females; a reduced explosive fitness (−2.68 [−3.24 to −2.12]); and a decreased upper-body strength in females (−1.52 [−2.16 to −0.87]). The fitness of young adults has been considerably compromised by COVID-19 lockdowns, highlighting the importance of promoting physical activity to prevent long-term health implications.
Ultra-low power neuromorphic obstacle detection using a two-dimensional materials-based subthreshold transistor
Authors: Thakar Kartikey , Rajendran Bipin , Lodha Saurabh 
Published: September 2023

AbstractAccurate, timely and selective detection of moving obstacles is crucial for reliable collision avoidance in autonomous robots. The area- and energy-inefficiency of CMOS-based spiking neurons for obstacle detection can be addressed through the reconfigurable, tunable and low-power operation capabilities of emerging two-dimensional (2D) materials-based devices. We present an ultra-low power spiking neuron built using an electrostatically tuned dual-gate transistor with an ultra-thin and generic 2D material channel. The 2D subthreshold transistor (2D-ST) is carefully designed to operate under low-current subthreshold regime. Carrier transport has been modeled via over-the-barrier thermionic and Fowler–Nordheim contact barrier tunneling currents over a wide range of gate and drain biases. Simulation of a neuron circuit designed using the 2D-ST with 45 nm CMOS technology components shows high energy efficiency of ~3.5 pJ per spike and biomimetic class-I as well as oscillatory spiking. It also demonstrates complex neuronal behaviors such as spike-frequency adaptation and post-inhibitory rebound that are crucial for dynamic visual systems. Lobula giant movement detector (LGMD) is a collision-detecting biological neuron found in locusts. Our neuron circuit can generate LGMD-like spiking behavior and detect obstacles at an energy cost of <100 pJ. Further, it can be reconfigured to distinguish between looming and receding objects with high selectivity. We also show that the spiking neuron circuit can function reliably with ±40% variation in the 2D-ST current as well as up to 3 dB signal-to-noise ratio with additive white Gaussian noise in the input synaptic current.
Barriers and facilitators to utilizing digital health technologies by healthcare professionals
Authors: Borges do Nascimento Israel Júnior , Abdulazeem Hebatullah , Vasanthan Lenny Thinagaran , Martinez Edson Zangiacomi , Zucoloto Miriane Lucindo , Østengaard Lasse , Azzopardi-Muscat Natasha , Zapata Tomas , Novillo-Ortiz David 
Published: September 2023

AbstractDigital technologies change the healthcare environment, with several studies suggesting barriers and facilitators to using digital interventions by healthcare professionals (HPs). We consolidated the evidence from existing systematic reviews mentioning barriers and facilitators for the use of digital health technologies by HP. Electronic searches were performed in five databases (Cochrane Database of Systematic Reviews, Embase®, Epistemonikos, MEDLINE®, and Scopus) from inception to March 2023. We included reviews that reported barriers or facilitators factors to use technology solutions among HP. We performed data abstraction, methodological assessment, and certainty of the evidence appraisal by at least two authors. Overall, we included 108 reviews involving physicians, pharmacists, and nurses were included. High-quality evidence suggested that infrastructure and technical barriers (Relative Frequency Occurrence [RFO] 6.4% [95% CI 2.9–14.1]), psychological and personal issues (RFO 5.3% [95% CI 2.2–12.7]), and concerns of increasing working hours or workload (RFO 3.9% [95% CI 1.5–10.1]) were common concerns reported by HPs. Likewise, high-quality evidence supports that training/educational programs, multisector incentives, and the perception of technology effectiveness facilitate the adoption of digital technologies by HPs (RFO 3.8% [95% CI 1.8–7.9]). Our findings showed that infrastructure and technical issues, psychological barriers, and workload-related concerns are relevant barriers to comprehensively and holistically adopting digital health technologies by HPs. Conversely, deploying training, evaluating HP’s perception of usefulness and willingness to use, and multi-stakeholders incentives are vital enablers to enhance the HP adoption of digital interventions.
Implications for implementation and adoption of telehealth in developing countries: a systematic review of China’s practices and experiences
Authors: Ye Jiancheng , He Lu , Beestrum Molly 
Published: September 2023

AbstractThe rapid advancement of telehealth technologies has the potential to revolutionize healthcare delivery, especially in developing countries and resource-limited settings. Telehealth played a vital role during the COVID-19 pandemic, supporting numerous healthcare services. We conducted a systematic review to gain insights into the characteristics, barriers, and successful experiences in implementing telehealth during the COVID-19 pandemic in China, a representative of the developing countries. We also provide insights for other developing countries that face similar challenges to developing and using telehealth during or after the pandemic. This systematic review was conducted through searching five prominent databases including PubMed/MEDLINE, Embase, Scopus, Cochrane Library, and Web of Science. We included studies clearly defining any use of telehealth services in all aspects of health care during the COVID-19 pandemic in China. We mapped the barriers, successful experiences, and recommendations based on the Consolidated Framework for Implementation Research (CFIR). A total of 32 studies met the inclusion criteria. Successfully implementing and adopting telehealth in China during the pandemic necessitates strategic planning across aspects at society level (increasing public awareness and devising appropriate insurance policies), organizational level (training health care professionals, improving workflows, and decentralizing tasks), and technological level (strategic technological infrastructure development and designing inclusive telehealth systems). WeChat, a widely used social networking platform, was the most common platform used for telehealth services. China’s practices in addressing the barriers may provide implications and evidence for other developing countries or low-and middle- income countries (LMICs) to implement and adopt telehealth systems.
A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors
Authors: Marques Da Costa Maria Eugénia , Zaidi Sakina , Scoazec Jean-Yves , Droit Robin , Lim Wan Ching , Marchais Antonin , Salmon Jerome , Cherkaoui Sarah , Morscher Raphael J. , Laurent Anouchka , Malinge Sébastien , Mercher Thomas , Tabone-Eglinger Séverine , Goddard Isabelle , Pflumio Francoise , Calvo Julien , Redini Francoise , Entz-Werlé Natacha , Soriano Aroa , Villanueva Alberto , Cairo Stefano , Chastagner Pascal , Moro Massimo , Owens Cormac , Casanova Michela , Hladun-Alvaro Raquel , Berlanga Pablo , Daudigeos-Dubus Estelle , Dessen Philippe , Zitvogel Laurence , Lacroix Ludovic , Pierron Gaelle , Delattre Olivier , Schleiermacher Gudrun , Surdez Didier , Geoerger Birgit 
Published: September 2023

AbstractPediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models within the European MAPPYACTS cancer precision medicine trial (NCT02613962). To date, 131 PDX models were established following heterotopical and/or orthotopical implantation in immunocompromised mice: 76 sarcomas, 25 other solid tumors, 12 central nervous system tumors, 15 acute leukemias, and 3 lymphomas. PDX establishment rate was 43%. Histology, whole exome and RNA sequencing revealed a high concordance with the primary patient’s tumor profile, human leukocyte-antigen characteristics and specific metabolic pathway signatures. A detailed patient molecular characterization, including specific mutations prioritized in the clinical molecular tumor boards are provided. Ninety models were shared with the IMI2 ITCC Pediatric Preclinical Proof-of-concept Platform (IMI2 ITCC-P4) for further exploitation. This PDX biobank of unique recurrent childhood cancers provides an essential support for basic and translational research and treatments development in advanced pediatric malignancies.
Positive and biphasic extracellular waveforms correspond to return currents and axonal spikes
Authors: Someck Shirly , Levi Amir , Sloin Hadas E. , Spivak Lidor , Gattegno Roni , Stark Eran 
Published: September 2023

AbstractMultiple biophysical mechanisms may generate non-negative extracellular waveforms during action potentials, but the origin and prevalence of positive spikes and biphasic spikes in the intact brain are unknown. Using extracellular recordings from densely-connected cortical networks in freely-moving mice, we find that a tenth of the waveforms are non-negative. Positive phases of non-negative spikes occur in synchrony or just before wider same-unit negative spikes. Narrow positive spikes occur in isolation in the white matter. Isolated biphasic spikes are narrower than negative spikes, occurring right after spikes of verified inhibitory units. In CA1, units with dominant non-negative spikes exhibit place fields, phase precession, and phase-locking to ripples. Thus, near-somatic narrow positive extracellular potentials correspond to return currents, and isolated non-negative spikes correspond to axonal potentials. Identifying non-negative extracellular waveforms that correspond to non-somatic compartments during spikes can enhance the understanding of physiological and pathological neural mechanisms in intact animals.