bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significados sobre metodología de la investigación en programas de doctorado en Educación. Una exploración desde su componente curricular
Authors: Jiménez Mora José , Moreno Bayardo María , De la Cruz Torres Frías José 
Published: May 2023

Este artículo aborda los significados del concepto «metodología de la investigación», inferidos a partir de la revisión de los planes y programas de estudios de tres programas de doctorado en Educación de México. Estos doctorados, además de diseños curriculares específicos, cuentan con profesores consolidados en procesos de investigación y varias generaciones de estudiantes formados(as). En este documento se explica el análisis realizado de los planes y programas, basado en la delimitación e interpretación de unidades de contenido presentes en el discurso curricular relacionadas con el concepto metodología de la investigación. Producto de lo anterior, se enuncian algunos hallazgos acerca de significados dados en cada programa doctoral a elementos clave de este concepto, junto con una mirada comparativa entre los tres programas, en el marco de estudio de la formación para la investigación educativa. Como parte de los resultados se encontraron nueve grandes atribuciones de significado al concepto, con distinto nivel de afinidad entre estos programas. Se comparten las concepciones de que la metodología de la investigación es más una lógica de generación de conocimiento que una definición de técnicas, así como el hecho de que comprende bases epistemológicas para métodos particulares. En todos los programas se sostiene, asimismo, el carácter de la metodología de la investigación como objeto de conocimiento y de formación en constante evolución.
La representación de los procesos fonológicos: a propósito del descenso vocálico del quechua
Authors: Pérez Jorge Iván 
Published: May 2023

La representación teórica dew1 objeto o de un proceso constituye la hipó­tesis del investigador sobre qué es tal objeto o cómo se lleva a cabo dicho proceso. La fonología es un área privilegiada en la que se puede observar esto con facilidad: la ontología fonológica -el conjunto de objetos que confor­man los procesos o fenómenos fonológicos-no está dada a priori ; debe ser construida teóricamente por el lingüista con el fin de dar cuenta de los daros de que dispone. En esta presentación, muestro distintas maneras de representar el conocido fenómeno fonológico de descenso o apertura de las vocales del quechua, desde la concepción de Trubetzkoy hasta la teoría de laoptimalidad.
Novel Functional Features of cGMP Substrate Proteins IRAG1 and IRAG2
Authors: Prüschenk Sally , Majer Michael , Schlossmann Jens 
Published: May 2023

The inositol triphosphate associated proteins IRAG1 and IRAG2 are cGMP kinase substrate proteins, which regulate intracellular Ca2+. Previously, IRAG1 was discovered as a 125 kDa membrane protein at the endoplasmic reticulum, that is associated with the intracellular Ca2+ channel IP3R-I and the PKGIβ and inhibits IP3R-I upon PKGIβ-mediated phosphorylation. IRAG2 is a 75 kDa membrane protein homologue of IRAG1 and was recently also determined as a PKGI substrate protein. Several (patho-)physiological functions of IRAG1 and IRAG2 were meanwhile and recently elucidated in a variety of human and murine tissues, e.g. of IRAG1 in various smooth muscles, heart, platelets and other blood cells, of IRAG2 in pancreas, heart, platelets and taste cells. Hence, lack of IRAG1 or IRAG2 leads to diverse phenotypes in these organs, e.g. smooth muscle and platelet disorders or secretory deficiency, respectively. This review aims to highlight the recent research regarding these both regulatory proteins to envision its molecular and (patho-)physiological tasks and to unravel its functional interplay as possible (patho-)physiological counterparts.
Pengaruh Persepsi Harga, E-Promosi, dan Citra Merek Terhadap Keputusan Pembelian Fashion Lokal
Authors: Herdian Akbar  , Osly Usman  , Dewi Agustin Pratama Sari  
Published: May 2023

ABSTRACT
This study aims to determine the effect of price perception, e-promotion, and brand image on purchasing decisions of 3Second products. This study using quantitative method, and a questionnaire instrument to collect data. The object of this research has 236 respondents who have bought 3Second products or respondents who have a desire to buy 3Second products. The data analysis used in this research is using SPSS applications to process and analyze research data. The results of hypothesis test showed that price perception, e-promotion, and brand image has a positive and significant effect on purchase decision.
Keyword: Price Perception, E-Promotion, Brand Image, Purchase Decision

ABSTRAK
Penelitian ini bertujuan untuk mengetahui pengaruh persepsi harga, e-promosi, dan citra merek terhadap keputusan pembelian produk 3Second. Penelitian ini menggunakan metode kuantitatif, dan instrumen kuesioner untuk memperoleh data. Objek penelitian ini memiliki 236 responden yang pernah membeli atau memiliki keinginan membeli produk 3Second. Analisis data yang digunakan dalam penelitian ini yaitu menggunakan aplikasi SPSS untuk mengolah dan menganalisis data hasil penelitian. Hasil dari uji hipotesis menunjukkan bahwa persepsi harga, e-promosi, dan citra merek memiliki pengaruh positif dan signifikan terhadap keputusan pembelian.
Kata kunci: Persepsi Harga, E-Promosi, Citra Merek, Keputusan Pembelian
Pengaruh Brand Image dan Trust terhadap Customer Loyalty Pelanggan Kopi di Jakarta dengan Customer Satisfaction sebagai Variabel Intervening
Authors: Ervina Kusuma Wardani  , Ika Febrilia  , Rahmi  
Published: May 2023

ABSTRACT
Domestic coffee consumption has increased significantly, which is around 6%-8% per year. As a result, coffee shops mushroomed in Indonesia, one of the most popular is Kopi Kenangan. This study aims to examine the effect of brand image and brand trust on customer loyalty with customer satisfaction as an intervening variable for customers aged 17-40 years who consume Kopi Kenangan in Jakarta. In this study, the sampling technique used purposive sampling with a total of 210 respondents obtained. The data processing is done using SEM (Structural Equation Model). The results show that brand image affects customer satisfaction, brand trust affects customer satisfaction, brand image affects customer loyalty, brand trust affects customer loyalty, customer satisfaction affects customer loyalty. Brand image influence on customer loyalty with customer satisfaction as the intervening variable and brand trust influence on customer loyalty with customer satisfaction as the intervening variable.
ABSTRAK
Konsumsi kopi dalam negeri mengalami peningkatan yang signifikan, yaitu sekitar 6%-8% per tahun. Alhasil, kedai kopi banyak menjamur di Indonesia, salah satu yang paling populer adalah Kopi Kenangan. Penelitian ini bertujuan untuk mengkaji pengaruh brand image dan brand trust terhadap loyalitas pelanggan dengan kepuasan pelanggan sebagai variabel intervening pada pelanggan usia 17-40 tahun yang mengkonsumsi Kopi Kenangan berdomisili di Jakarta. Pada penelitian ini teknik pengambilan sampel menggunakan purposive sampling dengan total diperoleh 210 responden dengan survei sebagai metode penelitian. Pengolahan data dilakukan dengan menggunakan SEM (Structural Equation Model). Hasil penelitian menunjukkan bahwa brand image mempengaruhi kepuasan pelanggan, brand trust mempengaruhi kepuasan pelanggan, brand image mempengaruhi loyalitas pelanggan, brand trust mempengaruhi loyalitas pelanggan, kepuasan pelanggan mempengaruhi loyalitas pelanggan. Brand image berpengaruh terhadap customer loyalty dengan customer satisfaction sebagai variabel intervening dan brand trust berpengaruh terhadap customer loyalty dengan customer satisfaction sebagai variabel intervening.
Pengaruh E-Promotion, E-Service Quality terhadap Repurchase Intention melalui E-Word of Mouth: Studi pada Aplikasi Coffee Shop di DKI Jakarta
Authors: Reza Setya Pratama  , Agung Kresnamurti Rivai P  , Andi Muhammad Sadat  
Published: May 2023

ABSTRACT
This study aims to determine the effect of e-promotion on repurchase intention, the effect of e-service quality on repurchase intention, e-word of mouth on repurchase intention, e-promotion on e-word of mouth, e-service quality on e-word of mouth. mouth, e-promotion of repurchase intention through e-word of mouth, e-service quality of repurchase intention through e-word of mouth, to Kopi Kenangan consumers in DKI Jakarta. The data collection method used is a survey method using a questionnaire instrument. The research sample collected was 255 respondents who are Kopi Kenangan consumers and have made purchases through the Kopi Kenangan application at least twice in the last six months. The software used in this research is SPSS and SEM (Structural Equation Model) from LISREL. The results of hypothesis testing indicate that there is a positive and significant relationship on all hypotheses.

ABSTRAK
Pada studi kali ini memiliki tujuan untuk mencari pengaruh e-promotion ke repurchase intention, pengaruh e-service quality ke repurchase intention, e-word of mouth terhadap repurchase intention, e-promotion ke e-word of mouth, e-service quality ke e-word of mouth, e-promotion terhadap repurchase intention melalui e-word of mouth, e-service quality ke repurchase intention melalui e-word of mouth, pada konsumen Kopi Kenangan di DKI Jakarta. Cara yang digunakan untuk mencari data yang digunakan adalah survey dengan memakai instrument formulir. Sampel penelitian yang dikumpulkan berjumlah 255 responden yang merupakan konsumen Kopi Kenangan dan pernah melakukan pembelian melalui aplikasi Kopi Kenangan minimal dua kali. Software yang dipakai pada studi kali ini yaitu SPSS dan SEM (Structural Equation Model) dari LISREL. Hasil uji hipotesis dikethaui bahwa adanya pengaruh yang baik dan signifikan untuk semua hipotesis.
Pengaruh Literasi Keuangan, Stress Keuangan, dan Toleransi Risiko terhadap Kepuasan Keuangan Generasi Milenial di Jakarta Pada Pengguna Dompet Digital
Authors: Amalia  , Buchdadi Agung Dharmawan , Kurnianti Destria 
Published: May 2023

ABSTRACT
This study empirically tests the effect of financial literacy, financial stressors, and risk tolerance on the financial satisfaction of the millennial generation in Jakarta using digital wallets. The data analysis method in this study uses Partial Least Square - Structural Equation. This study used a sample of 130 respondents. The data collection technique in this study used a questionnaire distributed to the millennial generation in Jakarta. The results of this study indicate that there is a positive and significant relationship between financial literacy and financial satisfaction, then there is an insignificant relationship between financial stress and financial satisfaction, and between risk tolerance and financial satisfaction in the millennial generation in Jakarta digital wallet users.

ABSTRAK
Tujuan dari penelitian ini adalah untuk menguji secara empiris pengaruh financial literacy, financial stressor, dan risk tolerance terhadap financial satisfaction generasi millennial di Jakarta pengguna dompet digital. Metode analisis data dalam penelitian ini menggunakan Partial Least Square – Structural Equation. Penelitian ini menggunakan sampel sebanyak 130 responden. Teknik pengambilan data pada penelitian ini menggunakan kuisioner yang disebar pada generasi milenial di Jakarta. Hasil dari penelitian ini menunjukkan bahwa terdapat hubungan yang positif dan signifikan antara literasi keuangan dan kepuasan keuangan, lalu tidak terdapat hubungan signifikan antara stress keuangan dan kepuasan keuangan, dan antara toleransi risiko dan kepuasan keuangan pada generasi milenial di Jakarta pengguna dompet digital.
Pengaruh Social Media Marketing, Brand Equity, dan Perceived Value Terhadap Continuance Intention pada Pengguna Marketplace di Jakarta
Authors: Pratiwi Bela , Andi Muhammad Sadat  , Terrylina Arvinta Monoarfa  
Published: May 2023

ABSTRACT
This study aims to determine the effect of social media marketing on brand equity, the effect of social media marketing on perceived value, the influence of social media marketing on customer satisfaction, the effect of brand equity on customer satisfaction, the effect of perceived value on customer satisfaction, the effect of customer satisfaction on user continuance intention of a marketplace in Jakarta. The survey method with the instrument in the form of a questionnaire is a data collection method used by researchers using a non-probability sampling technique with a convenience sampling method and also reinforced using an expert sampling technique. The sample of this research is 205 respondents who have shopped using a marketplace at least five times in the last six months and are Jakarta residents aged 17-44 years. Data analysis using SPSS version 25 and SEM (Structural Equation Model) from AMOS software version 26 to process and analyze research data. The results of this study indicate: 1) social media marketing has a significant effect on brand equity, 2) social media marketing has a significant effect on perceived value, 3) brand equity has a significant effect on customer satisfaction, 4) perceived value has a significant effect on customer satisfaction, 5) satisfaction significant effect on continuance intention.

ABSTRAK
Penelitian ini bertujuan untuk mengetahui pengaruh social media marketing terhadap brand equity, pengaruh social media marketing terhadap perceived value, pengaruh social media marketing terhadap customer satisfaction, pengaruh brand equity terhadap customer satisfaction, pengaruh perceived value terhadap customer satisfaction, pengaruh customer satisfaction terhadap continuance intention pengguna marketplace di Jakarta. Metode survei dengan instrument berupa kuesioner merupakan metode pengumpulan data yang digunakan peneliti menggunakan teknik sampel nonprobability sampling dengan metode convenience sampling dan juga diperkuat menggunakan teknik expert sampling. Sampel penelitian ini adalah 205 responden yang telah berbelanja menggunakan marketplace minimal lima kali dalam kurun waktu enam bulan terakhir dan merupakan warga Jakarta dengan usia 17-44 tahun. Data analisis menggunakan SPSS versi 25 dan SEM (Structural Equation Model) dari software AMOS versi 26 untuk mengolah dan menganalisa data hasil penelitian. Hasil penelitian ini menunjukkan: 1) social media marketing berpengaruh signifikan terhadap brand equity, 2) social media marketing berpengaruh signifikan terhadap perceived Value, 3) brand equity berpengaruh signifikan terhadap customer satisfaction, 4) perceived value berpengaruh signifikan terhadap customer satisfaction, 5) satisfaction berpengaruh signifikan terhadap continuance intention.
Pengaruh Kecenderungan Mengambil Risiko, Kebutuhan akan Prestasi dan Efikasi Diri terhadap Intensi Berwirausaha Mahasiswa di Jabodetabek
Authors: Anna Octaviani  , Corry Yohana  , Aditya Pratama  
Published: May 2023

ABSTRACT
The purpose of this study is to ascertain the influence of the proclivity to take risks on entrepreneurial ambitions, ascertain the effect of the demand for accomplishment on entrepreneurial intentions, and ascertain the effect of self-efficacy on entrepreneurial intentions. This study's population consists of Jabodetabek students. The sampling method employs probability sampling with up to 150 samples. IBM SPSS 22 is used for data analysis. Multiple Linear Regression is a technique used in data analysis. The findings revealed that the proclivity to take risks had a favorable and substantial influence on entrepreneurial inclinations. The urge for accomplishment has a favorable and considerable impact on entrepreneurial inclinations. Self-efficacy has no positive and negligible influence on entrepreneurial inclinations.

ABSTRAKi
Tujuan penelitian ini adalah untuk mengetahui pengaruh kecenderungan mengambil risiko terhadap ambisi berwirausaha, mengetahui pengaruh tuntutan prestasi terhadap niat berwirausaha, dan memastikan pengaruh efikasi diri terhadap intensi berwirausaha. Populasi penelitian ini adalah mahasiswa Jabodetabek. Metode pengambilan sampel menggunakan probability sampling hingga 150 sampel. IBM SPSS 22 digunakan untuk analisis data. Regresi Linear Berganda adalah teknik yang digunakan dalam analisis data. Temuan mengungkapkan bahwa kecenderungan mengambil risiko memiliki pengaruh yang menguntungkan dan substansial pada kecenderungan kewirausahaan. Kebutuhan akan berprestasi memiliki dampak yang menguntungkan dan cukup besar pada kecenderungan kewirausahaan. Efikasi diri tidak memiliki pengaruh positif dan tidak signifikan pada intensi berwirausaha.
Cyp2b6 and Sult1a1 Single Nucleotide Polymorphism: Implication for Nevirapine-based Hiv Therapy Among Ghanaians
Authors: Prah Isaac Egyir , Asiedu-Gyekye Isaac Julius , Nartey Edmund Tetteh , Aboagye Elvis Twumasi , Kudzi William 
Published: May 2023

Abstract
Background Nevirapine is used in many developing countries for the management of HIV-1 patients. Despite its usefulness, hypersensitivity reaction is a common complication that accounts for patients defaulting during therapy in Ghana. Genetic variations in drug-metabolizing enzymes have been implicated in reported adverse drug reactions observed in patients on nevirapine regimen. The study determined genotypic frequencies of specific CYP2B6 and SULT1A1 variants and their association with nevirapine hypersensitivity among persons living with HIV in the Ghanaian population.Methods An unmatched case-control study was conducted in a tertiary health facility in Ghana. Baseline clinical data were recorded from the patients’ folder. Genomic DNA (gDNA) samples were genotyped for CYP2B6*18 (c.983T > C) and SULT1A1*2 (c.638G > A) using Polymerase chain reaction-Restriction fragment length polymorphism (PCR-RFLP).Results Mean age of the patients was 38 ± 9.47 years with the majority 77.1% (54/70) of the participants being females. For CYP2B6*18 (c.983T > C) genotype frequencies, T/T and T/C were 94.3% (66/70) and 5.7% (4/70) respectively while for SULT1A1*2 (c.638G > A) genotype frequencies, G/G, G/A, and A/A were 61.4% (43/70), 34.3% (24/70) and 4.3% (3/70) respectively. The prevalence of CYP2B6*18 (c.983T > C) and SULT1A1*2 (c.638G > A) minor allele were 2.9% (4/140) and 21.4% (30/140) respectively among the study participants.Conclusion Extensive metabolizer genotypes for CYP2B6*18 (c.983T > C) and SULT1A1*2 (c.638G > A) were more common than the intermediate and poor metabolizer genotype. However, CYP2B6 983C/C representing poor metabolizers of CYP2B6*18 (c.983T > C) were not detected among the study population. Genetic polymorphism of CYP2B6*18 (c.983T > C) and SULT1A1*2 (c.638G > A) were not associated with nevirapine hypersensitivity. However, these variants may contribute to differential variations of other drug responses among the Ghanaian population.
The Sphere Conundrum: Using Voxel-based Dosimetry to evaluate sphere concentration and tumor dose in Hepatocellular Carcinoma treated with Y-90 Radioembolization
Authors: Sandow Tyler , Gimenez Juan , Nunez Kelley , Tramel Richard , Gilbert Patrick , Oliver Brianna , Cline Michael , Fowers Kirk , Cohen Ari , Thevenot Paul 
Published: May 2023

Abstract
Purpose To evaluate sphere concentration delivered to tumor and non-tumor tissue using voxel-based dosimetry as it relates to treatment, pathologic outcomes, and adverse events.Methods A retrospective, single-center analysis of patients (n = 57) with solitary HCC who were treated with Y90 radiation segmentectomy with Y90 glass microsphere infusion (TheraSphere; Boston Scientific, Marlborough, MA, USA) from 2020 to 2022 was performed. Post-treatment dosimetry was evaluated using Mirada DBx Build 1.2.0 Simplicit90Y dosimetry software. Voxel-based dosimetry and MIRD formula were utilized to calculate sphere concentration to tumor and non-tumor tissue. Time to progression (TTP), treatment response, pathologic response, and adverse events were studied.Results Fifty-seven patients with solitary tumors were analyzed with a median tumor diameter of 3.4cm (range 1.2-6.8cm). The median tumor absorbed dose was 692Gy (range, 256-1332Gy) with a median perfused treatment volume of 113mL (range, 33.6-442mL). Median sphere activity (SA) at time of delivery was 1428Bq (range, 412-2589Bq). Using voxel-based dosimetry and the MIRD formula, median tumor sphere concentration was 12,339 spheres/mL (range, 2,689 − 37,649 spheres/mL). Sphere concentration to tumor exhibited a weak, inverse correlation with perfused treatment volume (R2 = 0.25). However, tumor sphere concentration and non-tumor sphere concentration exhibited a direct, positive correlation (R2 = 0.72). Of the 52 tumors with post-treatment imaging, objective response was noted in 50 patients (96%) and complete response in 41 patients (79%). 98% of all treated tumors demonstrated a durable response at 2 years. The median time to progression for all patients was not reached with a 2-year progression rate of 11%. Multivariate analysis demonstrated target dose as the only statistically significant variable associated with TTP (p = 0.033). 14 patients underwent liver transplant. Median tumor necrosis was 99% (range, 80–100%).Conclusion Voxel-based dosimetry following Y90 radioembolization can be utilized to measure sphere concentration into tumor and non-tumoral tissue. Higher SA allows increased tumor absorbed dose with limited sphere/mL tumor capacity.
Performance and revolving analysis of Solar box cooker using PCM with prediction Hybrid deep Algorithms
Authors: kumar Gothandaperumal Palani , Muthucumaraswamy Rajamanickam , Chithambaram Venkatesan , Shanmugan Sengottaiyan 
Published: May 2023

Abstract
Human health is an important main part of the food to consideration in the performance analysis of PCM (Magnesium chloride hexahydrate - MgSO4. 7H2O) covered plastic balls (PBs) were augmented in Solar box-type cooker (SBC). The Artificial Neural Network (ANN) prediction analysis of thermal behavior in SBC is simulated and integrated using a tree and seed metaheuristic algorithm (TSA) an accuracy level was achieved in predicting SBC's efficiency. Hence, the enhancements entailed by introducing a variant may depend on improving ANN's concert. Engineering design found the optimal weights of the neurons using the TSA and includes a copper bar plate (CBP) with 50% higher thermal performance comparable to a silver bar plate (SBP). The functioning of the ANN/TSA technique using SBC has been simulated in the direction of predicting hourly variation by CBP & SBP with ANN/ANN/TSA is verified from food cooking efficiency related to predicting improvements of the SBC is applied as R2, RMSE, MRE, and MAE values like 0.99, 0.0475, 0.228, and 0.05 for the CBP design, while for the SBP design, they were 0.98, 0.086, 0.007, and 0.053, respectively. The R morals working out, testing, and whole statistics set of CBP design were 0.999, 0.995, and 0.997, respectively. For the SBP design, they were 1, 0.964, and 0.996, respectively. It is concluded that the SBC design with PCM-covered PBs and CBP improves cooking performance and increases the system's efficiency in preparing rice and eggs within 2 to 3 hrs.