bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global perspective of kidney diseases: Challenges and changes
Authors: Nangaku Masaomi 
Published: August 2023

AbstractChronic kidney disease (CKD) is a major public health issue worldwide. Although strategies for prevention, early detection and treatment to reduce the progression of CKD should remain continuous endeavours, public funding for kidney replacement therapy is urgently needed in low‐income countries (LICs) and lower‐middle‐income countries (LMICs). A multisectoral approach is needed to tackle the global burden of kidney disease. Getting a new drug, from first testing to final approval by a regulatory agency and ultimately to market, is a long, costly and risky process. While clinical trials and research have delivered new therapies and devices to patients with kidney disease during the last decade, there remains a significant residual risk for patients with CKD. Therefore, developing new drugs for better treatment and patient care is essential. For this purpose, the ISN held a consensus meeting entitled ‘TRANSFORM; TRAnslational Nephrology Science FOR new Medications’, which connected experts in the global kidney community and provided guidance on optimal management of translational animal studies for the development of new drugs to treat kidney diseases.
Exploring hospital practice types and their impact on glomerular pathologic patterns: Insights from the largest kidney biopsy cohort in Thailand
Authors: Kanjanabuch Talerngsak , Isaranuwatchai Suramath , Nopsopon Tanawin , Thammathiwat Theerachai , Pooprasert Thitipong , Puapatanakul Pongpratch , Pongpirul Krit , Chawanasuntorapoj Ratana , Kittiskulnam Piyawan , Eiam‐Ong Somchai , Tungsanga Kring , Chusil Saowaluck , Ophascharoensuk Vuddhidej , Vanichakarn Supat , Sitprija Visith , Boonpucknavig Vijitr ,   the Nephrology Society of Thailand
Published: August 2023

AbstractBackgroundThis study aims to investigate the influence of different kidney biopsy practices on the prevalence of glomerular pathologic patterns in the largest kidney biopsy registry in Thailand.MethodsWe conducted a retrospective review of kidney biopsy records from the period between 2000 and 2014. The records were obtained from 2 major institutions: King Chulalongkorn Memorial Hospital, a large university‐based hospital, and the Kidney Center Bangkok Hospital, which provides pathology services to hospitals throughout Thailand. The study included native kidney biopsies from all provinces in Thailand, excluding paediatric patients, kidney transplant recipients, and cases of inadequate and repeated biopsies. Patient demographics, indications for biopsy, and final glomerular diagnoses were compared across different hospital practice settings: university (UVH), private (PVH) and public (PBH).ResultsA total of 5893 eligible native kidney biopsies were identified from a pool of 7005 biopsies conducted over a 15‐year period in 25 provinces throughout Thailand. The 3 most common indications for biopsy were suspected kidney involvement in systemic lupus erythematosus (SLE) (29%), nephrotic syndrome (NS) (29%), and acute glomerulonephritis (AGN)/rapidly progressive glomerulonephritis (RPGN) (13%). The leading indication for biopsy differed across practice types, with suspected kidney involvement in SLE being the primary indication in UVH, while NS took precedence in both PBH and PVH practices. Notably, UVH performed fewer kidney biopsies for asymptomatic urinary abnormalities and diabetes‐related indications compared with PVH and PBH. The leading glomerular diagnoses correlated with the biopsy indications, with lupus nephritis (LN) being the most common diagnosis in UVH and PBH practices, whiles immunoglobulin A nephropathy was the predominant diagnosis in PVH practice.ConclusionHospital practice types significantly impact the prevalence of glomerular pathologic diagnosis patterns in kidney biopsy data, highlighting the importance of considering this influence in epidemiological comparisons.
Enhancing healthcare quality and outcomes for peritoneal dialysis patients in Thailand: An evaluation of key performance indicators and PDOPPS cohort representativeness
Authors: Boongird Sarinya , Phannajit Jeerath , Kanjanabuch Talerngsak , Chuengsaman Piyatida , Dandecha Phongsak , Halue Guttiga , Lorvinitnun Pichet , Boonyakrai Chanchana , Treamtrakanpon Worapot , Tatiyanupanwong Sajja , Lounseng Niwat , Perl Jeffrey , Johnson David W. , Pecoits‐Filho Roberto , Sritippayawan Suchai , Tungsanga Kriang , Kantachuvesiri Surasak , Ophascharoensuk Vuddhidej ,   Thailand PDOPPS Steering Committee and Advisory Board of Peritoneal Dialysis, The Nephrology Society of Thailand
Published: August 2023

AbstractAimTo assess whether the peritoneal dialysis (PD) centres included in the Peritoneal Dialysis Outcomes and Practise Patterns Study (PDOPPS) in Thailand are representative of other PD centres in the country, based on 8 key performance indicators (KPIs 1–8).MethodsA retrospective analysis was conducted comparing PD‐related clinical outcomes between PD centres included in the PDOPPS (the PDOPPS group) and those not included (the non‐PDOPPS group) from January 2018 to December 2019. Logistic regression analysis was used to identify predictors associated with achieving the target KPIs.ResultsOf 181 PD centres, 22 (12%) were included in the PDOPPS. PD centres in the PDOPPS group were larger and tended to serve more PD patients than those in the non‐PDOPPS group. However, the process and outcome KPIs (KPIs 1–8) were comparable between the 2 groups. Large hospitals (≥120 beds), providing care to ≥100 PD cases and having experience for >10 years were independent predictors of achieving the peritonitis rate target of <0.5 episodes/year. Most PD centres in Thailand showed weaknesses in off‐target haemoglobin levels and culture‐negative peritonitis rate.ConclusionsThe PD centres included in Thai PDOPPS were found to be representative of other PD centres in Thailand in terms of clinical outcomes. Thus, Thai PDOPPS findings may apply to the broader PD population in Thailand.
Constipation and clinical outcomes in peritoneal dialysis: Results from Thailand PDOPPS
Authors: Halue Guttiga , Tharapanich Huttaporn , Phannajit Jeerath , Kanjanabuch Talerngsak , Banjongjit Athiphat , Lorvinitnun Pichet , Sritippayawan Suchai , Sopassathit Wichai , Poonvivatchaikarn Ussanee , Buranaosot Somphon , Somboonsilp Wanida , Wongtrakul Pimpong , Boonyakrai Chanchana , Narenpitak Surapong , Tatiyanupanwong Sajja , Saikong Wadsamon , Uppamai Sriphrae , Panyatong Setthapon , Chieochanthanakij Rutchanee , Lounseng Niwat , Wongpiang Angsuwarin , Treamtrakanpon Worapot , Rattanasoonton Peerapach , Lukrat Narumon , Songviriyavithaya Phichit , Parinyasiri Uraiwan , Rojsanga Piyarat , Kanjanabuch Patnarin , Puapatanakul Pongpratch , Pongpirul Krit , Johnson David W. , Perl Jeffrey , Pecoits‐Filho Roberto , Ophascharoensuk Vuddhidej , Tungsanga Kriang ,   Thailand PDOPPS Steering Committee
Published: August 2023

AbstractBackgroundPatient‐reported outcome measures (PROMs) are widely recognized as valuable predictors of clinical outcomes in peritoneal dialysis (PD). Our study aimed to explore the connections between patient‐reported constipation and clinical outcomes.MethodsWe assessed constipation in patients across 22 facilities participating in the Thailand Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) from 2014 to 2017. Constipation diagnosis utilized objective assessment tools such as the Bristol stool form scale (BSFS) and a self‐reported questionnaire known as the constipation severity score (CSS). The BSFS is a 7‐level scale that visually inspects feces based on texture and morphology, while the CSS measures constipation duration and severity using a 5‐point Likert scale for various factors. We employed Cox proportional hazards model regression to determine the associations between constipation and clinical outcomes, including mortality, hemodialysis (HD) transfer and peritonitis.ResultsAmong 975 randomly selected PD patients from 22 facilities, 845 provided written informed consent, and 729 completed CSS questionnaire. Constipation was prevalent in the PD population (13%), particularly among older patients, those who were caregiver dependent, had diabetes and poorer nutritional status (indicated by lower time‐averaged serum albumin, potassium, creatinine and phosphate concentrations). Twenty‐seven percent of which experiencing symptoms of constipation for over a year. Notably, self‐reported constipation at baseline was significantly associated with a shorter time to first peritonitis and higher rates of peritonitis and death. However, no significant association was found between constipation and HD transfer after adjusting for various factors, including age, gender, PD vintage, comorbidities, shared frailty by study sites and serum albumin.ConclusionPatient‐reported constipation independently correlated with increased risks of peritonitis and all‐cause mortality, though no such correlation was observed with HD transfer. These findings underscore the need for further investigation to identify effective interventions for constipation in PD patients.
LncRNA MALAT1 promotes osteogenic differentiation through the miR‐93‐5p/SMAD5 axis
Authors: Gu Yingzhi , Bai Yuxing 
Published: August 2023

AbstractObjectivesPromoting the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) is a way to regenerate periodontal bone. This study aimed to determine whether lncRNA MALAT1 promotes the osteogenic differentiation of human PDLSCs in vitro.Materials and MethodsHuman PDLSCs were extracted from the human periodontal ligament, and after osteogenic differentiation was induced using osteogenic medium, the human PDLSCs were transfected with siRNA‐MALAT1, miR‐93‐5p mimics, and miR‐93‐5p inhibitors. The expression of osteogenesis‐related genes was assessed by RT–qPCR and western blotting, alkaline phosphatase (ALP) activity was assessed by ALP activity assay, and the formation of mineralized nodules was assessed by alizarin red S (ARS) staining. RNA immunoprecipitation (RIP) and luciferase assays were performed to assess the binding of MALAT1, miR‐93‐5p, and SMAD5.ResultsThe expression of lncRNA metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) was upregulated, while that of miR‐93‐5p was downregulated after PDLSC osteogenic differentiation. Knockdown of MALAT1 inhibited the osteogenic differentiation of PDLSCs, and MALAT1 expression negatively correlated with miR‐93‐5p expression. miR‐93‐5p inhibited the osteogenic differentiation of human PDLSCs by specifically binding to SMAD5.ConclusionMALAT1 regulates human PDLSC differentiation by regulating the miR‐93‐5p/SMAD5 axis.
A review of pediatric fasting guidelines and strategies to help children manage preoperative fasting
Authors: Zhang Eileen , Hauser Neil , Sommerfield Aine , Sommerfield David , von Ungern‐Sternberg Britta S. 
Published: August 2023

AbstractFasting for surgery is a routine step in the preoperative preparation for surgery. There have however been increasing concerns with regard to the high incidence of prolonged fasting in children, and the subsequent psycho‐social distress and physiological consequences that this poses. Additionally, the past few years have yielded new research that has shown significant inter‐individual variation in gastric emptying regardless of the length of the fast, with some patients still having residual gastric contents even after prolonged fasts. Additionally, multiple large‐scale studies have shown no long‐term sequalae from clear fluid aspiration, although two deaths from aspiration have been reported within the large Wake Up Safe cohort. This has led to a change in the recommended clear fluid fasting times in multiple international pediatric societies; similarly, many societies continue to recommend traditional fasting times. Multiple fasting strategies exist in the literature, though these have mostly been studied and implemented in the adult population. This review hopes to summarize the recent updates in fasting guidelines, discuss the issues surrounding prolonged fasting, and explore potential tolerance strategies for children.
Deciphering transcriptomic signatures explaining the phenotypic plasticity of nonheading lettuce genotypes under artificial light conditions
Authors: Yamashita Hiroto , Wada Kaede C. , Inagaki Noritoshi , Fujimoto Zui , Yonemaru Jun‐ichi , Itoh Hironori 
Published: August 2023

AbstractElucidating the mechanisms and pathways involved in genotype–environment (G×E) interactions and phenotypic plasticity is critical for improving plant growth. Controlled environment agricultural systems allow growers to modulate the environment for particular genotypes. In this study, we evaluated the effects of interactions among 14 genotypes and four artificial light environments on leaf lettuce phenotypes and dissected the underlying molecular mechanism via transcriptome‐based modeling. Variations in morphological traits and phytochemical concentrations in response to artificial light treatments revealed significant G×E interactions. The appropriate genotype and artificial light combinations for maximizing phenotypic expression were determined on the basis of a joint regression analysis and the additive main effect and multiplicative interaction model for these G×E interactions. Transcriptome‐based regression modeling explained approximately 50%–90% of the G×E variations. Further analyzes indicated Red Lettuce Leaves 4 (RLL4) regulates UV‐B and blue light signaling through the effects of the HY5–MBW pathway on flavonoid biosynthesis and contributes to natural variations in the light‐responsive plasticity of lettuce traits. Our study represents an important step toward elucidating the phenotypic variations due to G×E interactions in nonheading lettuce under artificial light conditions.
Gender and age influence the association between gait speed and mild cognitive impairment in community‐dwelling Japanese older adults: from the Japan Prospective Studies Collaboration for Ageing and Dementia (JPSC‐AD)
Authors: Bun Shogyoku , Suzuki Kouta , Niimura Hidehito , Shikimoto Ryo , Kida Hisashi , Shibata Mao , Honda Takanori , Ohara Tomoyuki , Hata Jun , Nakaji Shigeyuki , Maeda Tetsuya , Ono Kenjiro , Nakashima Kenji , Iga Jun‐ichi , Takebayashi Minoru , Ninomiya Toshiharu , Mimura Masaru ,   the JPSC‐AD Study Group
Published: August 2023

BackgroundStudies have shown that decreased gait speed is associated with impaired cognitive function. However, whether this association is equivalent across ages or genders in the older population remains unclear. Thus, we examined the association between mild cognitive impairment (MCI) and gait speed emphasising the influence of age and gender.MethodsOverall, 8233 Japanese participants aged ≥65 years were enrolled in this cross‐sectional study between 2016 and 2018. After stratification by gender and age group, the participants' gait speeds were divided into quintiles, and the difference in MCI prevalence at each gait speed quintile was calculated. Logistic regression analyses were performed to assess the odds of MCI for each quintile and to assess the influence of age and gender.ResultsMales had a consistently higher prevalence of MCI than females. The odds of MCI were increased as gait speed decreased. Logistic regression analyses revealed that in the multivariable‐adjusted model 2, the odds ratios (95% confidence interval; CI) for MCI were 2.02 (1.47–2.76) for females and 1.75 (1.29–2.38) for males in the slowest gait speed quintiles compared to the fastest quintile. In the stratified analyses, only males showed an age‐dependent increase in the associations between gait speed and MCI, while females exhibited comparable associations across age groups.ConclusionsReduced gait speed was associated with increased odds of MCI, and this association may vary according to gender and age. Therefore, gait speed could serve as a valuable screening tool for MCI, with gender‐ and age‐dependent clinical implications.
A particle method for 1‐D compressible fluid flow
Authors: Karafyllis Iasson , Papageorgiou Markos 
Published: August 2023

AbstractThis paper proposes a novel particle scheme that provides convergent approximations of a weak solution of the Navier‐Stokes equations for the 1‐D flow of a viscous compressible fluid. Moreover, it is shown that all differential inequalities that hold for the fluid model are preserved by the particle method: mass is conserved, mechanical energy is decaying, and a modified mechanical energy functional is also decaying. The proposed particle method can be used both as a numerical method and as a method of proving existence of solutions for compressible fluid models.
The power of teacher‐toddler relationships and stability of care for language development
Authors: Alves Jessica , Guedes Carolina , Cadima Joana 
Published: August 2023

AbstractThe value of positive teacher‐child relationships for child development is well established for preschool‐ and school‐age children, but little is known regarding children under the age of 3. The current study examined the links between teacher‐child relationship, stability of care, and toddlers’ expressive vocabulary. It also examined whether the associations between the expressive language and the teacher‐child relationship differ depending on the stability of care. Participants of the study were 212 toddlers (50.9% boys) and 36 teachers. Expressive vocabulary skills were assessed individually across two waves, and relationship quality was reported by teachers in the second wave. Results suggested that closeness was associated positively with expressive vocabulary, whereas neither conflict nor dependency were associated with vocabulary. Prior expressive vocabulary also positively predicted closeness, particularly for children with less stable relationships with teachers. Moreover, children who stayed with the same teacher were more likely to have closer, more dependent, and less conflictual relationships with them.
Grounded Cognition Entails Linguistic Relativity: Response to Commentators
Authors: Kemmerer David 
Published: August 2023

AbstractIn this paper, I respond to eight commentaries on my target article called “Grounded cognition entails linguistic relativity: A neglected implication of a major semantic theory.” The commentaries span a broad range of disciplines and perspectives. I have organized my response around the following topics: (1) an introductory synopsis of my main argument; (2) grounded versus amodal theories of concepts; (3) language‐specific versus language‐independent concepts; (4) language, culture, and cognition; (5) language itself as a source of conceptual grounding; (6) abstract concepts, linguistic relativity, and contextual and individual variability; (7) word meanings as language‐specific predictions; and (8) some final remarks about the importance of cross‐linguistic diversity.
Nucleic acid testing for monkeypox in United States blood donor specimens
Authors: Groves Jamel A. , Tonnetti Laura , Self Deanna , Yadav Manisha C. , Livezey Kristin , Linnen Jeffery M. , Stramer Susan L. 
Published: August 2023

AbstractBackgroundThe 2022 multi‐country outbreak of monkeypox (mpox) resulted in blood collection and public health agencies closely monitoring for changes in transmission dynamics that could pose a threat to the blood supply. While mpox virus (MPXV) is not known to be transfusion transmissible, there have been several studies demonstrating the detection of MPXV in blood. We evaluated the performance characteristics of a research use only (RUO) nucleic acid amplification test for MPXV. The assay was developed to detect MPXV DNA in plasma and serum specimens from human blood donors.Methods and MaterialsThe sensitivity of the RUO MPXV Assay was determined using a synthetic DNA sequence, purified full‐length genomic DNA, and a chemically inactivated virus. Specificity was determined using fresh plasma samples collected from blood donors during the outbreak. Plasma samples collected from donors considered at increased risk for exposure to mpox were also tested.ResultsFor sensitivity, the 95% limit of detection (LOD) ranged from 0.26 copies/mL (inactivated virus) to 31.65 copies/mL (synthetic DNA) to 166.61 copies/mL (for full‐length DNA). All donor samples tested with the RUO MPXV Assay were nonreactive, resulting in a specificity of 100% (95% CI, 99.93%–100.00%).DiscussionThe RUO MPXV Assay was developed as a potential blood donation screening assay in response to the outbreak. While not directly comparable, the 95% LOD fiducial limits obtained from partial‐ and full‐length DNA analysis were similar to other manufacturers' MPXV assays. Additionally, this assay demonstrated high specificity for screening blood donors.
Differential impact of missed initial wound clinic visit on 6‐month wound healing by race/ethnicity among patients with chronic limb‐threatening ischemia
Authors: Browder Sydney E. , Yohann Avital , Filipowicz Teresa R. , Freeman Nikki L. B. , Marston William A. , Heisler Stephen , Farber Mark A. , Patel Shrunjay R. , Wood Jacob C. , McGinigle Katharine L. 
Published: August 2023

AbstractChronic limb‐threatening ischemia (CLTI) is associated with significant morbidity, including major limb amputation, and mortality. Healing ischemic wounds is necessary to optimise vascular outcomes and can be facilitated by dedicated appointments at a wound clinic. This study aimed to estimate the association between successful wound care initiation and 6‐month wound healing, with specific attention to differences by race/ethnicity. This retrospective study included 398 patients with CLTI and at least one ischaemic wound who scheduled an appointment at our wound clinic between January 2015 and July 2020. The exposure was the completion status of patients' first scheduled wound care appointment (complete/not complete) and the primary outcome was 6‐month wound healing (healed/not healed). The analysis focused on how this association was modified by race/ethnicity. We used Aalen–Johansen estimators to produce cumulative incidence curves and calculated risk ratios within strata of race/ethnicity. The final adjustment set included age, revascularization, and initial wound size. Patients had a mean age of 67 ± 14 years, were 41% female, 46% non‐White and had 517 total wounds. In the overall cohort, 70% of patients completed their first visit and 34% of wounds healed within 6‐months. There was no significant difference in 6‐month healing based on first visit completion status for White/non‐Hispanic individuals (RR [95% CI] = 1.18 [0.91, 1.45]; p‐value = 0.130), while non‐White individuals were roughly 3 times more likely to heal their wounds if they completed their first appointment (RR [95% CI] = 2.89 [2.66, 3.11]; p‐value < 0.001). In conclusion, non‐White patients were approximately three times more likely to heal their wound in 6 months if they completed their first scheduled wound care appointment while White/non‐Hispanic individuals' risk of healing was similar regardless of first visit completion status. Future efforts should focus on providing additional resources to ensure minority groups with wounds have the support they need to access and successfully initiate wound care.
Dynamical properties of convex cocompact actions in projective space
Authors: Weisman Theodore 
Published: August 2023

AbstractWe give a dynamical characterization of convex cocompact group actions on properly convex domains in projective space in the sense of Danciger–Guéritaud–Kassel: we show that convex cocompactness in is equivalent to an expansion property of the group about its limit set, occurring in different Grassmannians. As an application, we give a sufficient and necessary condition for convex cocompactness for groups that are hyperbolic relative to a collection of convex cocompact subgroups. We show that convex cocompactness in this situation is equivalent to the existence of an equivariant homeomorphism from the Bowditch boundary to the quotient of the limit set of the group by the limit sets of its peripheral subgroups.