bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of Clinical Dynamic Contrast-Enhanced Magnetic Resonance Imaging Perfusion Modeling and Neoadjuvant Chemotherapy Response Prediction in Breast Cancer Using
18
FDG and
64
Cu-DOTA-Trastuzumab Positron Emission Tomography Studies
Authors: Whitman John , Adhikarla Vikram , Tumyan Lusine , Mortimer Joanne , Huang Wei , Rockne Russell , Peterson Joesph R. , Cole John 
Published: January 2025

PURPOSE
Perfusion modeling presents significant opportunities for imaging biomarker development in breast cancer but has historically been held back by the need for data beyond the clinical standard of care (SoC) and uncertainty in the interpretability of results. We aimed to design a perfusion model applicable to breast cancer SoC dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) series with results stable to low temporal resolution imaging, comparable with published results using full-resolution DCE-MRI, and correlative with orthogonal imaging modalities indicative of biophysical markers.

METHODS
Subsampled high-temporal-resolution DCE-MRI series were run through our perfusion model and resulting fits were compared for consistency. The fits were also compared against previously published results from institutions using the full resolution series. The model was then evaluated on a separate cohort for validity of biomarker indications. Finally, the model was used as a fundamental part of predicting response to neoadjuvant chemotherapy (NACT).

RESULTS
Temporally subsampled DCE-MRI series yield perfusion fit variations on the scale of 1% of the tumor median value when input frames are varied. Fits generated from pseudoclinical series are within the variation range seen between imaging sites (ρ = 0.55), voxel-wise. The model also demonstrates significant correlations with orthogonal positron emission tomography imaging, indicating potential for use as a biomarker proxy. Specifically, using the perfusion fits as the grounding for a biophysical simulation of response, we correctly predict the pathologic complete response status after NACT in 15 of 18 patients, for an accuracy of 0.83, with a specificity and sensitivity of 0.83 as well.

CONCLUSION
Clinical DCE-MRI data may be leveraged to provide stable perfusion fit results and indirectly interrogate the tumor microenvironment. These fits can then be used downstream for prediction of response to NACT with high accuracy.
mRNA Expression of Mineralocorticoid and Glucocorticoid Receptors in Human and Mouse Sensory Neurons of the Dorsal Root Ganglia
Authors: Qualls Katherine A. , Kadakia Feni K. , Serafin Elizabeth K. , Lückemeyer Debora De Nardin , Davidson Steve , Strong Judith A. , Zhang Jun-Ming 
Published: January 2025

BACKGROUND:
Corticosteroid receptors, including mineralocorticoid receptor (MR) and glucocorticoid receptor (GR), play important roles in inflammatory pain in the dorsal root ganglion (DRG). Although it is widely known that activating the GR reduces inflammatory pain, it has recently been shown that MR activation contributes to pain and neuronal excitability in rodent studies. Moreover, little is known about the translation of this work to humans, or the mechanisms through which corticosteroid receptors regulate inflammatory pain.

METHODS:
Corticosteroid receptor expression in human and mouse DRGs was characterized. RNAscope was used to perform high-resolution in situ hybridization for GR and MR mRNAs and to examine their colocalization with markers for nociceptors (SCN10A, NaV1.8 mRNA) and Aβ mechanoreceptors (KCNS1, Kv9.1 mRNA) in human DRG and C57BL/6J mouse DRG samples.

RESULTS:
GR and MR mRNAs are expressed in almost all DRG neurons across species. The 2 receptors colocalize in 99.2% of human DRG neurons and 95.9% of mouse DRG neurons (P = .0004, Fisher exact test). In both human and mouse DRGs, the large-diameter KCNS1+ Aβ mechanoreceptors showed a significantly higher MR/GR ratio (MR-leaning) compared to KCNS1− neurons (human: 0.23 vs 0.04, P = .0002; mouse: 0.35 vs −0.24, P < .0001; log ratios, unpaired t test), whereas small-diameter SCN10A+ nociceptive neurons showed a significantly lower MR/GR ratio (GR-leaning) compared to SCN10A− neurons (human: −0.02 vs 0.18, P = .0001; mouse: −0.16 vs 0.08, P < .0001; log ratios, unpaired t test).

CONCLUSIONS:
These findings indicate that mouse corticosteroid receptor mRNA expression reflects human expression in the DRG, and that mice could be a suitable model for studying corticosteroid receptor involvement in pain. Additionally, this study supports the translatability of rodent data to humans for the use of more selective corticosteroids at the DRG in pain treatments.
Efficacy of Neoadjuvant Radiotherapy After Chemotherapy and the Optimal Interval from Radiotherapy to Surgery for Borderline Resectable and Resectable Pancreatic Cancer
Authors: Yun Won-Gun , Chae Yoon Soo , Han Youngmin , Jung Hye-Sol , Cho Young Jae , Kang Hyun-Cheol , Kwon Wooil , Park Joon Seong , Chie Eui Kyu , Jang Jin-Young 
Published: January 2025

Abstract

Background
Benefits of neoadjuvant treatment for pancreatic cancer with major vessel invasion has been demonstrated through randomized controlled trials; however, the optimal neoadjuvant treatment strategy remains controversial, especially for radiotherapy. Therefore, we aimed to evaluate the efficacy and safety of neoadjuvant radiotherapy followed by chemotherapy and the optimal time interval to undergo surgery after radiotherapy in (borderline) resectable pancreatic cancer.

Methods
Between 2013 and 2022, patients with (borderline) resectable pancreatic cancer with vessel contact who received 5-fluorouracil with leucovorin, oxaliplatin, and irinotecan or gemcitabine and nanoparticle albumin-bound paclitaxel as initial treatment following surgery were included. Patients who received radiotherapy after chemotherapy and those who did not were matched using 1:1 nearest-neighbor propensity scores. Propensity scores were measured using the tumor size at initial image, duration of neoadjuvant chemotherapy, and responsiveness to neoadjuvant chemotherapy.

Results
Of 212 patients, 166 patients were retrieved for the matched cohort. Patients who received radiotherapy had significantly better postoperative survival, local control, and R0 resection rates than those who did not. Furthermore, patients who underwent surgery within 4 weeks after completing radiotherapy had lower intraoperative blood loss and a clinically relevant postoperative pancreatic fistula rate than those who underwent surgery after more than 4 weeks.

Conclusions
In patients with (borderline) resectable pancreatic cancer with vessel contact who were scheduled for curative-intent surgery after neoadjuvant chemotherapy, additional radiotherapy was associated with better postoperative survival and local control. Furthermore, our findings suggested that scheduling surgery within 4 weeks following radiation therapy might enhance the perioperative outcomes.
Clinical, radiologic, and pathologic study of intraosseous lipoma of the tibia: A case report
Authors: Liu Peng , Zhang Kai , Zeng Jian-Kang , Chang Yan-Feng , Zhuang Kai-Peng , Zhou Sheng-Hu 
Published: January 2025

BACKGROUND
Intraosseous lipoma of bone is one of the rarest benign bone tumors, which often involves the metaphysis of long tubular bones, especially the femur, tibia, fibula, and calcaneus. Bone lipoma can be characterized by chronic dull pain but can also be asymptomatic most of the time. As a result, it is less likely to attract people’s attention and is occasionally diagnosed through imaging examination during routine physical health check-up.
CASE SUMMARY
We describe a clinical case of intraosseous lipoma in a 21-year-old patient with chronic pain in the left lower limb for four years without any significant physical findings apart from the minimal swelling and local tenderness over the median ankle. Computerized tomography suggested the possibility of a lipoma on the left distal tibia, but the pathological examination could make a definite diagnosis. The intraosseous lipoma of the left distal tibia was treated by surgical curettage, bone graft, and internal fixation with steel plate, since the conservative treatment is often ineffective. Postoperatively, the patient made an uneventful recovery and was able to do daily activities without any restrictions. In addition, local recurrence of the intraosseous lipoma was not reported in subsequent reexamination.
CONCLUSION
Bone lipoma is very rare and often exhibits no characteristic clinical manifestation. The confirmative diagnosis of lipoma largely relies on a combination of imageology and biopsy. Surgical intervention is often recommended as a conventional therapy for bone lipoma. Postoperatively, the patient makes an uneventful recovery with a good prognosis, and the local recurrence of the tumor is also a low probability event.
Vitamin D, acute respiratory infections, and Covid-19: The curse of small-size randomised trials. A critical review with meta-analysis of randomised trials
Authors: Autier Philippe , Doi Giulia , Mullie Patrick , Vankrunkelsven Patrick , D’Ecclesiis Oriana , Gandini Sara 
Published: January 2025

Background
Randomised trials conducted from 2006 to 2021 indicated that vitamin D supplementation (VDS) was able to prevent severe COVID-19 and acute respiratory infections (ARI). However, larger randomised trials published in 2022 did not confirm the health benefits of VDS in COVID-19 patients.

Objective
To examine through a systematic review with meta-analysis the characteristics of randomised trials on VDS to COVID-19 patients and admission to intensive care unit (ICU), and of randomised trials on VDS for the prevention of ARI.

Method
A systematic search retrieved randomised trials on VDS to COVID-19 patients and admission to ICU. Data on VDS and ARI were extracted from the meta-analysis of Jolliffe et al. 2021. Groups were formed including trials with total numbers of patients below or above the median size of all trials. The associations between VDS vs no VDS, and admission to ICU were evaluated using random-effects models from which summary odds ratios (SOR) and 95% confidence intervals (CI) were obtained. Meta-analyses were done for all trials and for each group of trials, which allowed testing a possible effect modification of trial size. Publication bias was assessed using the Louis-Furuya-Kanaruori (LFK) index (no bias if index between -1 and +1) and the trim and fill method.

Results
Nine trials on VDS for preventing admission to ICU were identified, including 50 to 548 patients. The summary odds ratio (SOR) was 0.61 (95% CI: 0.39–0.95) for all trials, 0.34 (0.13–0.93) for trials including 50 to <106 patients and 0.88 (0.62–1.24) for trials including 106 to 548 patients (interaction p = 0.04). The LFK index was -3.79, and after trim and fill, the SOR was 0.80 (0.40–1.61). The SOR for the 37 trials on VDS for ARI prevention included 25 to 16,000 patients. The SOR was 0.92 (0.86–0.99) for all trials, 0.69 (0.57–0.83) for trials including 25 to <248 patients and 0.98 (0.94–1.03) for trials including 248 to 16,000 patients (interaction p = 0.0001). The LFK index was -3.11, and after trim and fill, the SOR was 0.96 (0.88–1.05).

Conclusion
Strong publication bias affected small randomised trials on VDS for the prevention of severe COVID-19 and of ARI. Systematic reviews should beware of small-size randomised trials that generally exaggerate health benefits.
Psychological detachment from work predicts mental wellbeing of working-age adults: Findings from the ‘Wellbeing of the Workforce’ (WoW) prospective longitudinal cohort study
Authors: Blake Holly , Hassard Juliet , Thomson Louise , Choo Wei Hoong , Dulal-Arthur Teixiera , Karanika-Murray Maria , Delic Lana , Pickford Richard , Rudkin Lou 
Published: January 2025

Background
There is an urgent need to better understand the factors that predict mental wellbeing in vocationally active adults during globally turbulent times.

Aim
To explore the relationship between psychological detachment from work (postulated as a key recovery activity from work) in the first national COVID-19 lockdown with health, wellbeing, and life satisfaction of working age-adults one year later, within the context of a global pandemic.

Methods
Wellbeing of the Workforce (WoW) was a prospective longitudinal cohort study, with two waves of data collection (Time 1, April-June 2020: T1 n = 337; Time 2, March-April 2021: T2 = 169) corresponding with the first and third national COVID-19 lockdowns in the UK. Participants were >18 years, who were employed or self-employed and working in the UK. Descriptive and parametric (t-tests and linear regression) and nonparametric (chi square tests) inferential statistics were employed.

Results
Risk for major depression (T1: 20.0% to T2: 29.0%, p = .002), poor general health (T1: 4.7% to T2: 0%, p = .002) and poor life satisfaction (T1: 15.4% to T2: 25.4%, p = .002) worsened over time, moderate-to-severe anxiety remained stable (T1: 26.1% to T2: 30.2%, p = .15). Low psychological detachment from work was more prevalent in the first wave (T1: 21.4% and T2: 16.0%), with a moderate improvement observed from T1 to T2 (t (129) = -7.09, p < .001). No differences were observed with work status (employed/self-employed), except for self-employed workers being more likely to report poor general health at T1 (16.1%, p = .002). Better psychological wellbeing, lower anxiety and higher life satisfaction at T2 were observed in those who reported better psychological detachment from work at T1 (β = .21, p = .01; β = -.43, p < .001; β = .32, p = .003, respectively), and in those who improved in this recovery activity from T1 to T2 (β = .36, p < .001; β = -.27, p < .001; β = .27, p = .008, respectively), controlling for age, gender and ethnicity.

Conclusion
The ability to psychologically detach from work during the first pandemic lockdown, and improvement in this recovery activity over time, predicted better mental wellbeing and quality of life in vocationally active adults after one year of a global crisis, irrespective of work status. Interventions to encourage workers to psychologically detach from work may help to support employee wellbeing at all times, not only in the extreme circumstances of pandemics and economic uncertainty.
Acceptability of a dapivirine levonorgestrel vaginal ring in two Phase 1 trials (MTN-030/IPM 041 and MTN-044/IPM 053/CCN019): Implications for multipurpose prevention technology development
Authors: Friedland Barbara A. , Gundacker Holly , Achilles Sharon L. , Chen Beatrice A. , Hoesley Craig , Richardson Barbra A. , Kelly Clifton W. , Piper Jeanna , Johnson Sherri , Devlin Brid , Steytler John , Kleinbeck Kyle , Dangi Bindi , Friend Chantél , Song Mei , Mensch Barbara , van der Straten Ariane , Jacobson Cindy , Hendrix Craig W. , Brown Jill , Blithe Diana , Hiller Sharon L. ,   on behalf of the MTN-030/IPM 041 and MTN-044/IPM 053/CCN019 Protocol Teams for the Microbicide Trials Network and the Contraceptive Clinical Trials Network
Published: January 2025

End-user feedback early in product development is important for optimizing multipurpose prevention technologies for HIV and pregnancy prevention. We evaluated the acceptability of the 90-day dapivirine levonorgestrel ring (DPV-LNG ring) used for 14 days compared to a dapivirine-only ring (DVR-200mg) in MTN-030/IPM 041 (n = 23), and when used for 90 days cyclically or continuously in MTN-044/IPM 053/CCN019 (n = 25). We enrolled healthy, non-pregnant, HIV-negative women aged 18–45 in Pittsburgh, PA and Birmingham, AL (MTN-030 only). Self-reports of vaginal bleeding and adherence (ring removals, expulsions) were collected via daily short message service. Acceptability data were recorded in face-to-face interviews at study exit. We assessed differences in acceptability by product characteristics and adherence; and associations between baseline characteristics/demographics, number of bleeding days, adherence, and overall acceptability. Most (21/23) women in the 14-day MTN-030 study and about half (13/25) in the 90-day MTN-044 study liked their assigned rings. In MTN-030 there were no significant associations between any variables and overall acceptability of either ring. In MTN-044, women who disliked the DPV-LNG ring had a significantly higher incidence of unanticipated vaginal bleeding, and reporting that vaginal bleeding changes were unacceptable than those who liked it. Although we found no overall association between adherence and acceptability, significantly more women who disliked (versus liked) the DPV-LNG ring reported expulsions during toileting. The DPV-LNG ring could meet the needs of women seeking simultaneous protection from HIV and unintended pregnancy. Addressing issues related to vaginal bleeding and expulsions early in product development will likely enhance acceptability of the DPV-LNG ring.
Trial registration: Clinical Trial Registration: MTN-030/IPM 041: ClinicalTrials.gov NCT02855346; MTN-044/IPM 053/CCN019: ClinicalTrials.gov NCT03467347.
Effect of one dose of ceftriaxone during endotracheal intubation on the incidence of aspiration pneumonia in cerebral hemorrhage patients: A randomized, controlled, double-blind clinical study protocol
Authors: Liu Xinyan , Wang Qizhi , Bi Yang , Yue Yanru , Song Xuan 
Published: January 2025

Introduction
Patients with cerebral hemorrhage often require a tracheal intubation to protect the airway and maintain oxygenation. Due to the use of analgesic and sedative drugs during endotracheal intubation and the opening of the glottis may easily cause aspiration pneumonia. Ceftriaxone is a semi-synthetic third-generation cephalosporin with strong antimicrobial activity against most gram-positive and gram-negative bacteria. It can effectively prevent and treat aspiration pneumonia.

Methods and analysis
This is a prospective, randomized, controlled, double-blind clinical study. Patients with intracerebral hemorrhage (ICH) undergoing endotracheal intubation in Dong E Hospital of Shandong Province from April 2023 to April 2025 will be enrolled and randomly assigned to the intervention group or control group. The intervention group will be treated using 100mL 0.9% sodium chloride with 2g ceftriaxone intravenously over the course of one hour beginning within two hours after endotracheal intubation. The control group will be given 100mL 0.9% sodium chloride injection intravenously of the course of one hour beginning within two hours after endotracheal intubation. The primary outcome is the incidence of aspiration pneumonia within 48 hours after endotracheal intubation. Secondary outcomes include: intensity of antimicrobial use, length of hospital stay, duration without mechanical ventilation, and 28-day mortality.

Discussion
The primary objective of this study is to explore whether a single dose of ceftriaxone administered during endotracheal intubation in patients with ICH reduced the incidence of pneumonia within 48 hours and provide evidence for the prevention of aspiration pneumonia in patients with ICH with endotracheal intubation.

Trial registration
The trial is registered at the Chinese Clinical Trial Registry: ChiCTR2200066837. Registered on December 19, 2022.
Regional governance as a success factor in protected area management. Network analysis of the Lüneburg Heath Nature Park (Germany)
Authors: Ströbel Kerstin , Job Hubert , Von Ruschkowski Eick 
Published: January 2025

Protected areas are crucial for landscape-scale conservation, but striking a balance between centralised guidance (heteronomy) and local autonomy (self-determination) is essential. This balance is particularly important for parks that cross administrative boundaries or impose land-use restrictions, as these factors can impact local acceptance and actors’ responsibilities. Analysing governance structures can unveil communication effectiveness, power distribution and collaboration levels within protected areas. This paper presents a network analysis intended to obtain empirical evidence of the above. To the best of our knowledge, this is the first such analysis to be conducted in a German conservation context. This approach reveals responsibility distributions and motives behind spatial interventions. In the pilot study of the Lüneburg Heath Nature Park, 34 actors were identified. In the core group, data was generated from 12 semi-structured expert interviews. We identified existing communicative and collaborative structures between key actors, local rights holders and stakeholders facing implementation challenges. Leveraging structures like the ‘Nature Conservation Coordination Group’, which has the status of a higher-level assembly, can encourage an open communication culture and affirm each actor’s value. We conclude that strengthening existing governance structures and implementing them on the ground, even on an informal basis, is essential for fostering a shared understanding and greater acceptance of landscape-scale conservation issues.
The Founding Meeting of the Claims Conference and its Record
Authors: Creangă Ovidiu 
Published: January 2025

Abstract
While the history of the Claims Conference has been documented, little is known about the meeting that established the organization over 70 years ago. This study examines the founding of the Claims Conference using its first record, the transcript of the meeting that took place at the Waldorf Astoria Hotel in New York City, on October 25–26, 1951. Many historical accounts about the Claims Conference offer cursory descriptions of its inception without examining the full scope of the debate underlying its founding. A few attempts in recent years have addressed this gap but a need for a more comprehensive analysis remains. This study explores the inaugural meeting through the lens of the organizations that took part in the conference and demonstrates the important role they played in shaping the outcome of the conference. By examining the transcript of that meeting in greater detail, this study contributes to a deeper understanding of the Claims Conference’s origin and of its subsequent history.
Es braucht Beziehungen, auch an Hochschulen
Authors: Tschopp Lukas 
Published: January 2025

Zusammenfassung
Die zunehmende Präsenz von KI in der Hochschulbildung wirft Fragen über die Bedeutung menschlicher Beziehungen auf. Der Artikel argumentiert, dass trotz – oder gerade wegen – technologischer Entwicklungen persönliche Beziehungen für erfolgreiches Lernen zentral bleiben. Lehrende und Bibliotheksmitarbeitende spielen dabei eine wichtige Rolle, indem sie Räume für Dialog, kritische Reflexion und echten Austausch schaffen.