bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainability performance assessment of sago industry supply chain using a multi-criteria adaptive fuzzy inference model
Authors: Yusmiati Yusmiati , Machfud Machfud , Marimin Marimin , Sunarti Titi Candra 
Published: June 2023

Background: Sustainable supply chains are more competitive than conventional supply chains. Supply chain sustainability performance needs to be carried out to determine sustainability under current conditions and to design appropriate strategies to increase sustainability. This study aims to design a sustainability performance assessment model for the sago agro-industry supply chain and identify critical indicators for sustainability improvement. Methods: The Fuzzy Inference System (FIS) evaluates sustainability on three levels: economic, social, and environmental. The Adaptive Neuro-Fuzzy Inference System (ANFIS) is then used to aggregate the overall sustainability performance. The cosine amplitude method (CAM) was used to analyze key indicators. This study assessed the sustainability performance on industrial- and small-medium-scale sago agro-industry. Results: The results show that the supply chain sustainability performance on the industrial scale is 44.25, while it is 48.81 for the small-medium scale with the same status, almost sustainable. Key indicators for improving sago agro-industry supply chain sustainability performance include profit distribution among supply chain actors, institutional support for supply chains, waste utilization (reuse & recycle), and the availability of waste management facilities. The implication of this research for managers regards assessing the current status of sustainability performance and key indicators as a reference for formulating sustainability strategies and practices. Conclusions: The results of the study will enable supply chain actors to understand the key indicators for improving sustainability performance in the sago agro-industry supply chain, especially in Meranti Islands Regency, Riau Province. The proposed model can be applied to other agro-industries by adjusting the indicators used and assessing data availability and suitability for the research object.
Robust Combination Testing: Methods and Application to COVID-19 Detection
Authors: Jain Sanjay , Jónasson Jónas Oddur , Pauphilet Jean , Ramdas Kamalini 
Published: June 2023

Simple and affordable testing tools are often not accurate enough to be operationally relevant. For coronavirus disease 2019 (COVID-19) detection, rapid point-of-care tests are cheap and provide results in minutes, but they largely fail policy makers’ accuracy requirements. We propose an analytical methodology, based on robust optimization, that identifies optimal combinations of results from cheap tests for increased predictive accuracy. This methodological tool allows policy makers to credibly quantify the benefits from combination testing and thus, break the trade-off between cost and accuracy. Our methodology is robust to noisy and partially missing input data and incorporates operational constraints—relevant considerations in practice. We apply our methodology to two data sets containing individual-level results of multiple COVID-19 rapid antibody and antigen tests, respectively, to generate Pareto-dominating receiver operating characteristic curves. We find that combining only three rapid tests increases out-of-sample area under the curve by 4% (6%) compared with the best-performing individual test for antibody (antigen) detection. We also find that a policy maker who requires a specificity of at least 0.95 can improve sensitivity by 8% and 2% for antibody and antigen testing, respectively, relative to available combination testing heuristics. Our numerical analysis demonstrates that robust optimization is a powerful tool to avoid overfitting, accommodate missing data, and improve out-of-sample performance. Based on our analytical and empirical results, policy makers should consider approving and deploying a curated combination of cheap point-of-care tests in settings where “gold standard” tests are too expensive or too slow. This paper was accepted by Stefan Scholtes, healthcare management. Supplemental Material: The data files and electronic companion are available at https://doi.org/10.1287/mnsc.2023.4826 .
Employment Preparation Experiences of Youth With Intellectual Disability and Autism Who Attend College-Based Transition Programs
Authors: Papay Clare , Grigal Meg , Choiseul-Praslin Belkis 
Published: June 2023

Abstract
College-based transition programs offer students with intellectual disability and autism (ID/A) the opportunity to navigate adult learning experiences with similar-aged peers, accessing college coursework and employment experiences while continuing to receive support from or coordinated by their local school system. The present study used data from college-based transition programs included in the Transition and Postsecondary Programs for Students with Intellectual Disability (TPSID) model demonstration program to examine the composition of employment preparation activities including paid employment and the association with having paid employment upon exiting from the program. The findings suggest that college-based transition programs hold promise as a model for supporting the transition to paid employment for students with ID/A. Implications for research and practice are discussed.
Cellular heterogeneity in the 16HBE14o− airway epithelial line impacts biological readouts
Authors: Kerschner Jenny L. , Paranjapye Alekh , Harris Ann 
Published: June 2023

AbstractThe airway epithelial cell line, 16HBE14o−, is an important cell model for studying airway disease. 16HBE14o− cells were originally generated from primary human bronchial epithelial cells by SV40‐mediated immortalization, a process that is associated with genomic instability through long‐term culture. Here, we explore the heterogeneity of these cells, with respect to expression of the cystic fibrosis transmembrane conductance regulator (CFTR) transcript and protein. We isolate clones of 16HBE14o− with stably higher and lower levels of CFTR in comparison to bulk 16HBE14o−, designated CFTRhigh and CFTRlow. Detailed characterization of the CFTR locus in these clones by ATAC‐seq and 4C‐seq showed open chromatin profiles and higher order chromatin structure that correlate with CFTR expression levels. Transcriptomic profiling of CFTRhigh and CFTRlow cells showed that the CFTRhigh cells had an elevated inflammatory/innate immune response phenotype. These results encourage caution in interpreting functional data from clonal lines of 16HBE14o− cells, generated after genomic or other manipulations.
Nitric oxide‐mediated cutaneous microvascular function is not altered in middle‐aged‐to‐older adults following mild SARS‐CoV‐2 infection: A pilot study
Authors: Dillon Gabrielle A. , Wolf S. Tony , Williams Auni C. , Kenney W. Larry , Alexander Lacy M. 
Published: June 2023

AbstractWe tested the hypothesis that post‐COVID‐19 adults (PC) would have impaired cutaneous nitric oxide (NO)‐mediated vasodilation compared to controls (CON). We performed a cross‐sectional study including 10 (10 F/0 M, 69 ± 7 years) CON and 7 (2 F/5 M, 66 ± 8 years) PC (223 ± 154 days post‐diagnosis). COVID‐19 symptoms severity (survey) was assessed (0–100 scale for 18 common symptoms). NO‐dependent cutaneous vasodilation was induced by a standardized 42°C local heating protocol and quantified via perfusion of 15 mM NG‐nitro‐L‐arginine methyl ester during the plateau of the heating response (intradermal microdialysis). Red blood cell flux was measured with laser‐Doppler flowmetry. Cutaneous vascular conductance (CVC = flux/mm Hg) was presented as a percentage of maximum (28 mM sodium nitroprusside +43°C). All data are means ± SD. The local heating plateau (CON: 71 ± 23% CVCmax vs. PC: 81 ± 16% CVCmax, p = 0.77) and NO‐dependent vasodilation (CON: 56 ± 23% vs. PC: 60 ± 22%, p = 0.77) were not different between groups. In the PC group neither time since diagnosis nor peak symptom severity (46 ± 18 AU) correlated with NO‐dependent vasodilation (r < 0.01, p = 0.99 and r = 0.42, p = 0.35, respectively). In conclusion, middle‐aged and older adults who have had COVID‐19 did not have impaired NO‐dependent cutaneous vasodilation. Additionally, in this cohort of PC, neither time since diagnosis nor symptomology were related to microvascular function.
Differential effects of repeated inspiratory and limb muscle loading on effort perception in patients with obstructive sleep apnea and healthy males
Authors: Griffith‐Mcgeever Claire , Owen Julian , Earing Christopher , McKeon Damian , Kubis Hans‐Peter 
Published: June 2023

AbstractObstructive sleep apnea (OSA) is characterized by collapse of the upper airways during sleep. The contribution of alterations in effort perception is not understood. This study investigated the response of inspiratory and quadriceps muscles to repetitive loading on effort perception in OSA patients, pre and post continuous positive airway pressure (CPAP) treatment, and in healthy individuals. Twenty‐one OSA patients and 40 healthy participants completed protocols for repetitive inspiratory and leg muscle loading combined with intermittent rating of perceived exertion (RPE 14—somewhat hard/hard) to assess effort sensitivity. Electromyography, inspiratory pressure and isometric force were measured. OSA patients reported higher fatiguability of respiratory and leg muscles than controls. OSA patients revealed lower effort sensitivity in the leg muscles compared with controls, while repetitive loading led to a decline in force production. In the respiratory system, OSA patients revealed similar effort sensitivity at baseline compared with controls, but a large reduction in effort sensitivity after loading. Baseline effort sensitivity was correlated with apnea‐hypopnea index (AHI). After CPAP treatment, OSA patients revealed a decreased baseline effort sensitivity with a missing loading response. Effort sensitivity was differentially affected in the respiratory and leg systems with outcomes of CPAP treatment suggesting a full reversibility. Outcomes suggest that reversible adaptive response of effort perception in the respiratory system might contribute to the severity of OSA.
Management and outcomes in secondary diabetes among pediatric patients hospitalized with hemophagocytic lymphohistiocytosis
Authors: Schweisberger Cintya , Palaniappan Nila , Wood Nicole M. , Amos Lauren E. , Halpin Kelsee 
Published: June 2023

Abstract

Objectives
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder marked by massive cytokine release from macrophage and T-cell activation. Hallmarks include fever, splenomegaly, cytopenias, hypertriglyceridemia, hypofibrinogemia, and elevations in ferritin and soluble IL-2 receptor. Given the association of HLH with inflammation and glucocorticoid therapy, the development of hyperglycemia is not unexpected. Descriptions of the prevalence of secondary diabetes in youth diagnosed with HLH are lacking.

Methods
Retrospective review from 2010 through 2019 of hospitalized youth 0–21 years diagnosed with HLH. The primary outcome of interest was the development of secondary diabetes, defined as a serum glucose 200 mg/dL or higher necessitating insulin therapy.

Results
Of 28 patients with HLH, 36 % (n=10) developed secondary diabetes. The only risk factor associated with secondary diabetes was an infectious cause of HLH (60 % vs. 27.8 %, p 0.041). Intravenous regular insulin was used in 80 % of patients with a mean duration of 9.5 days (2–24 days). Most (70 %) needed insulin within 5 days of starting steroids. Stays in the ICU were longer (median 20 vs. 3 days, p 0.007) and intubation more likely (90 vs. 45 %, p 0.041) among those with secondary diabetes. Mortality was high (16–30 %) regardless of insulin use (p 0.634).

Conclusions
One-third of hospitalized pediatric patients with HLH developed secondary diabetes requiring insulin therapy. Insulin is typically started within 5 days of initiating steroids, limited to IV infusions, and often is not needed by discharge. Secondary diabetes was associated with longer ICU stays and heightened risk of intubation.
Are preschool children sensitive to the function of accessibility markers? A visual world study with German-speaking three- to four-year-olds
Authors: Lehmkuhle Ina , Schimke Sarah 
Published: June 2023

Abstract
Little is known about when children understand the function of anaphoric referring expressions to signal different degrees of accessibility of discourse referents. This visual world study investigates German-speaking three- to four-year-olds’ online processing and offline interpretation of repeated names and personal pronouns in a context where reference is made to highly accessible discourse referents. Repeated names are markers of low accessibility, whereas personal pronouns are preferentially used to refer to highly accessible referents. For online processing, results showed a significant effect of referring expression: children looked at the target picture more often after hearing a personal pronoun than after hearing repeated names. Offline results revealed no significant differences between the two conditions. We conclude that German-speaking preschool children are sensitive to the function of accessibility markers during online processing, and suggest that the difference between online and offline results may be due to the different task demands.
Design and analysis of lattice structure applied humerus semi-prosthesis
Authors: Savran Efe , Kalay Onur Can , Alp Nazmi Bülent , Karpat Fatih 
Published: June 2023

Abstract
Bone tissue loss may occur in bone structures, which are one of the elements that provide the body’s endurance and movement of living things, due to situations such as falling, hitting, or cancer formation. In bad scenarios, applications such as an external plate or internal rod addition are made to regain the old durability of the structure. At the same time, full or semi-prosthesis applications can be made in cases where the original bone structure cannot be preserved. With today’s advanced possibilities, lattice structures can be produced effortlessly with the additive manufacturing (AM) method. Here, the formation of the structure that can show anisotropic behavior depending on the production and the effect of the roughness caused by the production quality should also be seen in the process plan. In this study, it was aimed to compare the durability of titanium (Ti-6Al-4V) and magnesium (ZK60) materials for humeral half prosthesis using cubic-based lattice structure and to show their differences compared to the original bone structure. Maximum stress and deformation values were obtained by performing analyses with the finite element method on the lattice semi-humerus prosthesis obtained with this aim. Reliability analysis was made on the data obtained, and parameter optimization of the lattice structure was aimed. As a result of the study, it was seen that the lattice structure with 65% porosity compared to the reference values is reliable and with the same reliability rate, magnesium provides approximately 60% lightness compared to titanium.
The crystal structure of 5,7-dinitropyrazolo[5,1-b]quinazolin-9(4H)-one, C10H5N5O5
Authors: Jin Shouwen , Zhang Qiong , Zhen Yaoqi , Shi Chengzhe , Wang Daqi 
Published: June 2023

Abstract
C10H5N5O5, monoclinic, P21/c (no. 14), a = 10.9546(11) Å, b = 7.3433(8) Å, c = 13.2567(15) Å, β =

102.972

(
5
)

∘

$102.972{(5)}^{\circ }$

, V = 1039.19(19) Å3, Z = 4,

R

g
t

${R}_{gt}$

(F) = 0.0630,

w

R

r
e
f

$w{R}_{ref}$

(F
2) = 0.1622, T = 298 K.
Electrophilic substitution reactions of thiophene and thieno[2,3-b]thiophene heterocycles: a DFT study
Authors: Savoo Nandini , Mungur Chahlaa , Rhyman Lydia , Ramasami Ponnadurai , Joule John A. 
Published: June 2023

Abstract
We determined the most preferred site for the electrophilic aromatic substitution (SEAr) reactions of thiophene 1 and thieno[2,3-b]thiophene 2 using the N-chlorosuccinimide electrophile in the gas phase and in acetic acid. The B3LYP/6-311G(d), B3LYP-D3/6-311G(d) and M06-2X/6-311G(d) methods were employed to investigate the SEAr reaction mechanisms. We found that, compared to the β-carbon atom, the α-carbon atom in both 1 and 2 is preferred for electrophilic attack both kinetically and thermodynamically.
Native observers’ evaluations of ritual frame indicating expressions in Chinese
Authors: Li Hui , Ji Jie 
Published: June 2023

Abstract
Ritual frame indicating expressions (henceforth RFIEs) is a concept that re-conceptualizes expressions that are conventionally understood as politeness markers and provides insight into the interface between expressions and politeness. This study supplements previous studies on RFIEs, which are mostly conducted from an analyst perspective, by analyzing native observers’ evaluations of a participant’s use of Chinese RFIEs in the speech act of request. It is found that the use of RFIEs was evaluated as either excessively limao (Chinese politeness1) or limao. The underlying reason for the former evaluation is that the expressions were interpreted as deference markers, and the underlying reason for the latter evaluation is that the expressions were interpreted as civility markers. This study demonstrates that, at least in the speech act of request, RFIEs may indicate different ritual frames for different native observers, which calls for the incorporation of the (meta)participant’s perspective in the study of RFIEs. It also supplements the current view on the usage of conventional politeness-related expressions in Chinese.
Elternstress und erhöhte Ansprüche in der frühen Familienphase – Ein Hindernis für die Nutzung von Unterstützungsangeboten?
Authors: Liese Désirée , Ulrich Susanne M. , Löchner Johanna , Lux Ulrike 
Published: June 2023

Zusammenfassung
Elterlicher Stress ist weit verbreitet und kann sich negativ auf das Familienklima und die kindliche Entwicklung auswirken. Um den Unterstützungsbedarf einschätzen zu können, sollen die Bedeutung von elterlichem Stress und Barrieren der Hilfeannahme aufgezeigt werden. Darüber hinaus wird in der Studie untersucht, welche Persönlichkeitsmerkmale das Risiko einer Überlastung erhöhen.
Elternbildung als zentraler Faktor für eine resiliente Kindesentwicklung
Authors: Eickhorst Andreas 
Published: June 2023

Zusammenfassung
Entscheidend für eine resiliente Kindesentwicklung sind frühkindliche Erfahrungen. Hier kommt den Eltern als Beziehungs- und Bindungspersonen die zentrale Rolle zu, welche aber nicht immer leicht auszufüllen ist. Deshalb sind Angebote der Elternbildung relevant in der Zeit des Übergangs zur Familie – in den Frühen Hilfen und darüber hinaus. Im Beitrag soll diese Zeit mit ihren Herausforderungen und anschließend exemplarisch zwei Elternkurse als Beispiele der Elternbildung vorgestellt werden.
STARK-Onlinehilfe: Unterstützungsbedarfe von Kindern getrennter Eltern
Authors: Uemminghaus Monika , Zimmermann Janin , Lux Ulrike 
Published: June 2023

Zusammenfassung
(Klein)Kinder in Trennungsfamilien sind häufiger als gleichaltrige Kinder in Kernfamilien von Belastungen ihrer psychischen und körperlichen Gesundheit betroffen - mit zum Teil langfristigen Auswirkungen. Die Onlinehilfe-Plattform STARK stellt ein niedrigschwelliges, digitales Informationsangebot rund um eine Trennung mit Kindern dar. Sie möchte betroffene Eltern darin unterstützen, die Anpassung ihrer Kinder an die Trennung zu erleichtern, sich selbst zu stabilisieren und Beratungsstellen vor Ort zu finden.
Digitalisierung in den Frühen Hilfen – Erfahrungen, Chancen, Herausforderungen
Authors: Renner Ilona 
Published: June 2023

Zusammenfassung
Zur Aufrechterhaltung der Frühen Hilfen während der Covid-19-Pandemie mussten Fachkräfte, Familien und Kommunen ihre Unterstützungsangebote verstärkt auf digitale Formate verlagern, um die Corona-Schutzregelungen einzuhalten. Dies stellte alle Beteiligten vor besondere Herausforderungen, da die Frühen Hilfen in ihrer Grundkonzeption auf persönlichen Kontakten beruhen. Mit der Erprobung digitaler Lösungen wurden jedoch auch die Chancen, die eine Ergänzung der persönlichen Kontakte durch digitale Angebote bietet, deutlich sichtbar.
The role of spontaneous vs. experimentally induced attentional strategies for the pain response to a single bout of exercise in healthy individuals
Authors: Titze Christina , Konietzny Kerstin , Gajsar Hannah , Koltyn Kelli , Chehadi Omar , Hasenbring Monika I. , Vaegter Henrik Bjarke 
Published: June 2023

Abstract

Objectives
Exercise-induced pain and exercise-induced hypoalgesia (EIH) are well described phenomena involving physiological and cognitive mechanisms. Two experiments explored whether spontaneous and instructed mindful monitoring (MM) were associated with reduced exercise-induced pain and unpleasantness, and increased EIH compared with spontaneous and instructed thought suppression (TS) in pain-free individuals.

Methods
Eighty pain-free individuals participated in one of two randomized crossover experiments. Pressure pain thresholds (PPTs) were assessed at the leg, back and hand before and after 15 min of moderate-to-high intensity bicycling and a non-exercise control condition. Exercise-induced pain and unpleasantness were rated after bicycling. In experiment 1 (n=40), spontaneous attentional strategies were assessed with questionnaires. In experiment 2, participants (n=40) were randomly allocated to use either a TS or MM strategy during bicycling.

Results
In experiment 1, the change in PPTs was significantly larger after exercise compared with quiet rest (p<0.05). Higher spontaneous MM was associated with less exercise-induced unpleasantness (r=−0.41, p<0.001), whereas higher spontaneous TS was associated with higher ratings of exercise-induced unpleasantness (r=0.35, p<0.05), but not with pain intensity or EIH. In experiment 2, EIH at the back was increased in participants using instructed TS compared with participants using instructed MM (p<0.05).

Conclusions
These findings suggest that spontaneous and presumably habitual (or dispositional) attentional strategies may primarily affect cognitive-evaluative aspects of exercise, such as feelings of exercise-induced unpleasantness. MM was related to less unpleasantness, whereas TS was related to higher unpleasantness. In terms of brief experimentally-induced instructions, TS seems to have an impact on physiological aspects of EIH; however, these preliminary findings need further research.
Exact chirped solutions of the perturbed Gerdjikov–Ivanov equation with spatio-temporal dispersion
Authors: Tang Ming-Yue 
Published: June 2023

Abstract
In this paper, the perturbed Gerdjikov–Ivanov equation with spatio-temporal dispersion is investigated. The trial equation method, the complex envelope travelling wave transformation, and the complete discriminant system for polynomial method, respectively, are all utilized. As a consequence, twenty-eight exact chirped solutions are obtained, and some representative two-dimensional patterns under concrete parameters are presented. The results acquired are conducive to studying the dynamic behavior of solitons.