bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Mental Health: Where We Are and Where We Are Going
Authors: Moitra Modhurima , Owens Shanise , Hailemariam Maji , Wilson Katherine S. , Mensa-Kwao Augustina , Gonese Gloria , Kamamia Christine K. , White Belinda , Young Dorraine M. , Collins Pamela Y. 
Published: May 2023

AbstractPurpose of ReviewTo summarize recent findings in global mental health along several domains including socioeconomic determinants, inequities, funding, and inclusion in global mental health research and practice.Recent FindingsMental illness continues to disproportionately impact vulnerable populations and treatment coverage continues to be low globally. Advances in integrating mental health care and adopting task-shifting are accompanied by implementation challenges. The mental health impact of recent global events such as the COVID-19 pandemic, geo-political events, and environmental change is likely to persist and require coordinated care approaches for those in need of psychosocial support. Inequities also exist in funding for global mental health and there has been gradual progress in terms of building local capacity for mental health care programs and research. Lastly, there is an increasing effort to include people with lived experiences of mental health in research and policy shaping efforts.SummaryThe field of global mental health will likely continue to be informed by evidence and perspectives originating increasingly from low- and middle-income countries along with ongoing global events and centering of relevant stakeholders.
Holmium and Thulium Fiber Laser Safety in Endourological Practice: What Does the Clinician Need to Know?
Authors: Juliebø-Jones Patrick , Somani Bhaskar K. , Gjengstø Peder , Æsøy Mathias Sørstrand , Beisland Christian , Ulvik Øyvind 
Published: May 2023

Abstract

Purpose of Review
To summarise the literature on laser safety during endourological practice.

Recent Findings
Holmium and Thulium Fiber laser are the two main energy sources in the current clinical practice. The latter may have superior properties, but more clinical studies are needed to formally establish this. Laser injury to urothelium is more dependent on user experience rather than laser type. Smaller laser fibres allow for lower intra-renal temperature profiles. Operators should pay close attention to laser technique including maintaining the safety distance concept and only firing the laser when tip is clearly in view. When adjusting laser settings, pay close attention to resultant power given the associated heat changes. Prolonged periods of laser activation are to be avoided for the same reason. Outflow can be manipulated such as with access sheath to mitigate temperature and pressure changes. There is still limited evidence to support the mandate for compulsory use of eye protection wear during laser lithotripsy.

Summary
Lasers are the gold standard energy source for stone lithotripsy. However, the safe clinical application of this technology requires an understanding of core principles as well as awareness of the safety and technical aspects that can help in protecting patient, surgeon and operating staff.
Automated detection of inorganic powders in X-ray images of airport luggage
Authors: Vukadinovic Danijela , Osés Miguel Ruiz , Anderson David 
Published: May 2023

AbstractAt the checkpoint, the detection of illicit inorganic powders in passenger luggage using conventional X-ray can be challenging. An algorithm is presented for the automated detection of inorganic powder-like substances from complex X-ray images of highly cluttered passenger bags using computer vision. The proposed method utilizes support vector machine (SVM) classifiers built from local binary patterns (LBP) texture features. When tested on a dataset created in-house, the algorithm achieves a detection precision of 97% and a false positive rate of 3%. This is the first study performed on a realistic dataset, including different amounts and shapes of powders and electronic clutter, and where the success of the automated method is compared with inter-observer variability.
Versteckte Vielfalt: Diversität von Zellen im industriellen Bioprozess
Authors: Arulrajah Prasika , Heins Anna-Lena 
Published: May 2023

AbstractPopulation heterogeneity poses a major challenge in industrial scale bioprocesses, affecting process performance but also leading to more robust phenotypes. To investigate this phenomenon, multiple fluorescent reporter strains are cultivated under simulated industrial scale conditions in multi-compartment bioreactors. This approach significantly raises the quantitative understanding of population heterogenity which is needed before its benefits can help to develop high-yielding, more robust bioprocesses.
Markierung und Identifikation von Protein-Mikroumgebungen in Pilzen
Authors: Hollstein Lucas S. , Schmitt Kerstin , Stahlhut Gertrud , Valerius Oliver , Pöggeler Stefanie 
Published: May 2023

AbstractThe proximity-dependent biotin identification (BioID) method allows the in vivo examination of molecular environments of proteins. The methodology is based on the labeling of proteins with biotin that are proximal to a protein of interest, followed by affinity purification and identification via mass spectrometry. This article describes the application of BioID in fungi.
Proteomdynamik im Gefäßsystem von Pflanzen
Authors: Kasper Karl Henrik , Polle Andrea 
Published: May 2023

AbstractIn higher plants, the xylem, which is crucial for water and nutrient transport, also contains a diverse proteome. The composition of the xylem sap proteome responds dynamically to changes in environmental conditions. Important functions are maintenance of structural integrity and defense against invading pathogens. Knowledge on signals that trigger proteomic changes is scarce. Better understanding of these processes may contribute to improve plant performance in a changing climate.
Grüne Zellfabriken – Mikroalgen für die nachhaltige Bioproduktion
Authors: Einhaus Alexander , Baier Thomas , Kruse Olaf 
Published: May 2023

AbstractMicroalgal biotechnology promises a sustainable production of valuable bioproducts. Thanks to their photosynthetic nature, they are able to convert atmospheric CO2 into various products, ranging from simple biomass, platform chemicals for bioplastics to high value compounds for the pharmaceutical and fragrance industry. Here we present important improvements for engineering strategies to advance microalgae as green cell factories for the production of valuable bioproducts.
Anticancer efficacy of hirsuteine against colorectal cancer by opposite modulation of wild-type and mutant p53
Authors: Zhang Yan , Guo Tingting , Li Shurong , Ren Zehao , Gao Shan , Lu Hao , Ma Xuelan , Liu Donghui , Liu Yao , Kong Dexin , Qiu Yuling 
Published: May 2023

Abstract
Purpose
The present study aimed to explore the anticancer activity of hirsuteine (HST), an indole alkaloid from the traditional Chinese herbal medicine Uncaria rhynchophylla, against colorectal cancer (CRC) and the underlining mechanism.

Methods
MTT, colony formation, flow cytometry and MDC staining were conducted to confirm the antiproliferative effect of HST on human CRC cells harboring different p53 status. Protein expressions were evaluated by the Western blot analysis. p53 protein half-life and the interaction between p53 and MDM2 were investigated using cycloheximide (CHX)-chase assay and Co-immunoprecipitation (Co-IP), respectively. Transcriptional activity of p53 was examined by qRT-PCR and Chromatin immunoprecipitation (ChIP). Xenograft tumor in nude mice was created to evaluate in vivo anticancer effect of HST against CRC.

Results
HST inhibited cell growth, arrested cell cycle and induced autophagy, showing efficient anticancer effects on CRC cells independent of p53 status. In HCT-8 cells, HST prolonged wtp53 half-life, and upregulated mRNA level of p21, suggesting that HST activated the p53 pathway through enhancement of wtp53 stability and transcriptional activity. Meanwhile in SW620 cells, HST induced MDM2-mediated proteasomal degradation of mutp53R273H, increased the DNA-binding ability of mutp53R273H at the p21 promoter, and upregulated mRNA levels of p21 and MDM2, demonstrating the depletion of mutp53R273H and restoration of its wild-type-like properties by HST. p53 knockdown by siRNA significantly impaired the growth inhibition of HST on HCT-8 and SW620 cells. Moreover, HST showed anticancer effects in xenograft tumors, accompanied with an opposite regulation of wtp53 and mutp53 R273H in mechanism.

Conclusion
This study revealed the anticancer efficacy of HST against CRC via opposite modulation of wtp53 and mutp53 R273H, indicating the potential of HST to be a CRC drug candidate targeting p53 signaling.
Assessment of the activity of the mbalmayo thermal power plant on groundwater quality
Authors: Goune A. C. , Seutche J. C. , Ekani R. Y. , Essombo B. E. , Nsouandele J. L. , Ben-bolie G. H. 
Published: May 2023

AbstractGroundwater is essential for daily life in Cameroon, but pollution sources can harm its quality through infiltration and dispersal of contaminants in the ground. This study focuses on estimating groundwater quality near the Mbalmayo Thermal Power Plant using a predictive model combining genetic algorithms and neural networks. The genetic algorithms were used to optimize the objective function, while neural networks learned the data to predict concentration values. From January 2017 to December 2021, several moisture content values were experimentally determined using collected dried and weighed soil samples. The results showed that moisture content varied from 1 to 82%. During this study period, the model takes into account the water content of the soil, porosity and permeability which have the same effect on the concentration level of the fuel oil in the groundwater. The average concentration of fuel oil was below 50 mg/l, which is the World Health Organisation standard However, there is a risk of groundwater pollution by fuel oil in the event of heavy activity at the Mbalmayo thermal power plant in the 0-445 m range. For protection during this period, the results show that the installation of populations on a perimeter located beyond 445 m and the construction of a water purification station are recommended. The results are decision support tools for the authorities.
DownScaleBench for developing and applying a deep learning based urban climate downscaling- first results for high-resolution urban precipitation climatology over Austin, Texas
Authors: Singh Manmeet , Acharya Nachiketa , Jamshidi Sajad , Jiao Junfeng , Yang Zong-Liang , Coudert Marc , Baumer Zach , Niyogi Dev 
Published: May 2023

AbstractCities need climate information to develop resilient infrastructure and for adaptation decisions. The information desired is at the order of magnitudes finer scales relative to what is typically available from climate analysis and future projections. Urban downscaling refers to developing such climate information at the city (order of 1 – 10 km) and neighborhood (order of 0.1 – 1 km) resolutions from coarser climate products. Developing these higher resolution (finer grid spacing) data needed for assessments typically covering multiyear climatology of past data and future projections is complex and computationally expensive for traditional physics-based dynamical models. In this study, we develop and adopt a novel approach for urban downscaling by generating a general-purpose operator using deep learning. This ‘DownScaleBench’ tool can aid the process of downscaling to any location. The DownScaleBench has been generalized for both in situ (ground- based) and satellite or reanalysis gridded data. The algorithm employs an iterative super-resolution convolutional neural network (Iterative SRCNN) over the city. We apply this for the development of a high-resolution gridded precipitation product (300 m) from a relatively coarse (10 km) satellite-based product (JAXA GsMAP). The high-resolution gridded precipitation datasets is compared against insitu observations for past heavy rain events over Austin, Texas, and shows marked improvement relative to the coarser datasets relative to cubic interpolation as a baseline. The creation of this Downscaling Bench has implications for generating high-resolution gridded urban meteorological datasets and aiding the planning process for climate-ready cities.
Three Cu (II)-hydrazone complexes: synthesis, physicochemical characteristics, stability, thermal analysis, and investigation of metal and iodine absorption
Authors: Alzharani Ahmed A. 
Published: May 2023

AbstractA three Schiff bases; Lhy, Lme, and Lph, as well as their CuLhy, CuLme, and CuLph complexes, were synthesized, and their physicochemical properties were investigated. Vibrational spectra proposed that the hydrazone ligands reacted as neutral tridentate chelator with NNO chelating centers to the Cu(II) ion via azomethine-N, Isatin-carbonyl, and pyridine-N forming the general formulae [Cu(L)2]Cl2 nH2O, where L = neutral tridentate Isatin-hydrazone ligand (L = Lhy, (CuLhy); L = Lme, (CuLme); L = Lph, (CuLph)). TG/DTA analyses have shown that there is at least one water molecule in each of the complexes. The spectrophotometric method was used to calculate the stoichiometry and thermodynamic characteristics of the metal complexes. By using density functional theory (DFT) techniques, the 3D structure of the produced complexes was verified. Based on an investigation of the electronic structural configurations of the complexes, calculations verified the predicted structure and clarified the nature of the chemical reactivity. Cu(II) adsorption from aqueous solutions onto ligands was investigated in a number of different settings. The influence of the initial metal concentration (10–100 ppm), the weight of the hydrazone ligands (0.1–1.0 gm), and the contact period (1–2 h) were all investigated as potential moderators of the uptake behavior. In just three hours, equilibrium had been reached thanks to the speedy adsorption process. An initial pH of ≈ 6–8 with a metal ion concentration of 80 ppm was found to be optimal. Iodine (I2) uptake behavior of hydrazone ligands was also studied using spectroscopy. In the first 8 h, hydrazone ligands exhibited high adsorption efficiency (E, %), which gradually declined until equilibrium was achieved after 25 h.
Graphical abstract
PneuPrint: 3D printing on inflatables
Authors: Lin Che Wei , Mattei Gabriele , Cheibas Ina , Du Chaoyu , Aejmelaeus-Lindström Petrus , Gramazio Fabio 
Published: May 2023

Abstract
This research investigated the feasibility of thermoplastic 3D printing on inflatable membranes. Five experiments were performed in an iterative process through design and manufacture (1), computational simulation and 3D scanning (2), and robotic fabrication on the pneumatic formwork (3). These experiments ranged from small to large-scale 3D printing. Experiment 1 demonstrated the small-scale feasibility of the process and the need to integrate an air-pressure control loop. Experiment 2 investigated the technique transfer from small to large-scale. Experiment 3 analyzed the deviation and shape accuracy of the inflatable membrane. Experiment 4 identified the required fabrication settings and compatibility between the membrane and the 3D printing material. Finally, Experiment 5 demonstrated the design and fabrication potential of large-scale 3D printed elements on pneumatic formworks. The results proved high potential for building freeform design elements for architectural applications on pneumatic formworks.
A parametric study and performance investigation of thermoelectric refrigeration system using computational fluid dynamics
Authors: N Rudresha , M Vijay Kumar , Math Mahantesh M. 
Published: May 2023

AbstractGlobal commercial market forecasted around 45 billion US dollars for refrigeration equipment in 2021. Currently used refrigerants have high global warming potential (GWP); hence, environment-friendly refrigeration system using the Peltier effect is being considered for this research. The thermodynamic refrigeration system has a low coefficient of performance (COP), when compared to chlorofluorocarbon (CFC) and hydrofluorocarbon (HCFC) refrigeration systems. The design of various models of the thermoelectric refrigerator (TER) is created using ANSYS workbench. Each new design is analysed with computational fluid dynamics (CFD) analysis tool by altering insulating materials such as nickel with aluminium foil and polyurethane foam in airflow streamline of thermoelectric refrigeration. Temperature differences obtained between 7.5 and 9.4 °C are tabulated after each run using the finite volume method. Optimization of inner design and insulation material is done by using computational fluid dynamics analysis in the ANSYS FLUENT software. The results of sharp edge design have proved better when compared to partially round edge design and fillet design, 7.85 °C for the cold region and 54.85 °C for the hot region. Further research is expected using the multistage Peltier module and smart temperature control unit to improve the COP of the TER system.
Aetiology of Acute Undifferentiated Fever Among Children Under the Age of Five in Vietnam: A Prospective Study
Authors: Tran Xuan Duong , Hoang Van Thuan , Dang Thi Thuy Duong , Vu Thi Phuong , To Minh Manh , Tran Trong Kiem , Do Manh Dung , Nguyen Duy Cuong , Nguyen Quoc Tien , Colson Philippe , Parola Philippe , Marty Pierre , Gautret Philippe 
Published: May 2023

AbstractBackgroundTo investigate the aetiology of acute undifferentiated fever (AUF) among children under the age of five in Vietnam.MethodsThis prospective study was conducted in the Thai Binh paediatric hospital, between July 2020 and July 2021 among children with AUF at admission. Real-time PCR testing 18 microbial pathogens were done on blood samples.Results286 children were included, with median age of 16 months. 64.7% were male. 53.9% were positive for at least one pathogen by PCR. Enterovirus, human herpesvirus 6, adenovirus, and varicella zoster virus PCR were positive for 31.1, 12.6, 1.4, and 1.0% patients, respectively. Other pathogens tested negative by PCR. During the hospital stay, based on clinical criteria 47.2% children secondarily presented with signs of respiratory tract infections, 18.9% had hand, foot and mouth disease, 4.6% had chickenpox. 4.2% presented signs of central nervous system infections, 1.0% had dengue (antigenic test) and 1.0% had signs of gastrointestinal infection. Finally, 23.1% patients presented a fever with or without a rash and no other symptoms and ultimately received a diagnosis of AUF.ConclusionReal-time PCR of blood is useful for detecting pathogens and diagnosing infectious causes of AUF. Further prospective studies with blood and urine culture testing and PCR investigation of not only blood but also cerebrospinal fluid, throat, and skin samples according to symptoms would be of interest to confirm the predominance of viral infections in children with AUF and to guide therapeutic options.
Dysfunctional schema modes as determinants of psychiatric comorbidities: a study in a cohort of people with epilepsy
Authors: Shafique Nadia , Arafat S.M. Yasir , Siddiqui Fowzia , Malik W.T. , Hallahan Brian , Khalily Muhammad Tahir 
Published: May 2023

AbstractIntroduction and Aims:Symptomatology of epilepsy and its’ associated alteration in brain processes, stigma of experiencing seizures, and adverse sequelae of anti-epileptics have been demonstrated to impact behaviour and exacerbate psychopathology. This study examines the role of dysfunctional schema modes in People with Epilepsy (PWE) and their association with psychiatric symptoms.Methods:Semi-structured interviews were conducted with 108 PWE treated with anti-epileptics for at least one year and with no history or mental disorder or psycho-active substance use. Clinical symptoms were measured utilising the Symptom Checklist-90 (SCL-90) with schema modes measured utilising the Schema Mode Inventory (SMI).Results:Maladaptive coping and child schema modes were significantly higher in individuals from lower socio-economic status group (p < 0.01), with several maladaptive schema modes more prevalent in males. Hostility symptoms were increased in individuals from lower socio-economic classes and were more prevalent early in disease course. Several psychological symptoms including somatisation, interpersonal, obsession, depression, paranoia, hostility, phobia, anxiety, and psychoticism, were predicted by various maladaptive schema modes (p < 0.001).Conclusion:This study highlights the impact of maladaptive schemas, suggesting that PWE might benefit from the introduction of appropriate psychotherapeutic interventions such as schema-focused therapy, particularly if from lower socio-economic classes or in the early stages of theirdisease course.
Bilingual profiles differentially predict executive functions during early childhood: A latent profile analysis
Authors: Yang Hwajin , Tng Germaine Y. Q. , Ng Wee Qin , Yang Sujin 
Published: May 2023

AbstractRecent studies suggest that heterogeneous bilingual experiences implicate different executive functions (EF) in children. Using a latent profile analysis, we conducted a more nuanced investigation of multifaceted bilingual experiences. By concurrently considering numerous bilingual indicators – age of L1 and L2 acquisition, interactional contexts of verbal exchanges, L1 and L2 proficiency, balance of language use at home and school, and receptive vocabulary – we identified three latent profiles (subgroups): balanced dual-language, dominant single-language, and mixed-interaction. We found that the balanced dual-language and dominant single-language profiles predicted significantly better switching than the mixed-interaction profile. However, no profile differences were found in working memory, prepotent response inhibition, or inhibitory control. These results held true when multiple covariates (age, sex, household income, and nonverbal intelligence) were controlled for. Using a person-centered approach, our study underscores that disparate bilingual experiences asymmetrically predict the shifting facet of EF during early childhood.