bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influencing factors of incision healing in HIV positive patients with giant cell tumor of long bone in extremities
Authors: Ma Rui , Zhang Yao , Zhang Qiang 
Published: March 2023

Abstract
Objective
To evaluate the risk factors that affect wound healing after surgery of giant cell tumor in patients with human immunodeficiency virus (HIV).
Methods
20 patients of giant cell tumor with HIV were recruited from June 2018 to June 2022, once diagnosed, 20 patients were receive timely HAART (Highly Active Antiretroviral Therapy) with China's first choice of national free HAART drug containing tenofovir disoproxil fumarate, lamivudine and efavirenz (TDF + 3TC + EFV, ). and 20 patients of giant cell tumor without HIV were enrolled as control at same time. All patients were underwent the same surgical method. Observe the incidence of infection at the surgical site and risk factors that affect wound healing were evaluated.
Results
The incidence of poor outcome of wound healing in HIV-positive group was higher than HIV-negative group (p < 0.05), but there was no significant difference in infection of the wound between two groups (p > 0.05). Multivariable regression analysis demonstrated that CD4 + T-lymphocyte count and clinical categories of HIV were independent risk factors for postoperative wound healing (p < 0.05), while age, gender, operation time,albumin,hemoglobin and combined disease, were not (p > 0.05).
Conclusion
The wound can be healed normally in most of HIV-positive patients with giant cell tumor, and the outcome of postoperative wound healing was significantly associated with CD4 + T-lymphocyte coun and HIV clinical category. At the same time, we recommended that reasonable perioperative adjuvant treatments, including nutritional support and immunomodulators, and anti-retroviral drugs should be used.
Damage Identification Based on the Nodal Line Active Modulation Method
Authors: Feng Kan , Li Rong , Yan Jing , Hu Xu , Zhou Jie , Li Zheng 
Published: March 2023

Abstract
A novel vibration-based method (VBM) for damage identification named nodal line active modulation (NLAM) is proposed in this study. Unlike traditional VBMs, NLAM can identify damage by taking advantage of the nodal line effect, which is observed when the defect is located on the nodal lines. In these cases, the dynamic responses of the structure remain nearly unchanged. Through numerical studies, we have elaborated on the theory in detail and painted a clearer picture of the steps in the NLAM process through a cleft detection in an aluminum plate. In experimental research, piezoelectric transducers work as both actuators and sensors for intact and damaged carbon fiber reinforced plastic laminates, while a scanning laser Doppler vibrometer measures the full-field response for the intact structure only. The added mass damage is visualized from the highlighted nodal lines of the modulated operational deflection shapes. The present investigation provides a new idea for VBM damage detection, which should provide practical applications for structural health monitoring.
Small Flying Object Detection and Tracking in Digital Airport Tower through Spatial-Temporal ConvNets
Authors: Thai Phat , Alam Sameer , Lilith Nimrod , Nguyen Binh 
Published: March 2023

Abstract
Digital towers using high-resolution cameras that cover a 360-degree view of airports have recently been applied as a solution for some airports by replacing conventional towers. Although many computer vision systems have been developed as tools to assist tower controllers, small flying object detection remains challenging due to their small dimensions and unpredictable trajectories. This paper proposes a novel computer vision framework to detect, track and recognize small flying objects, namely aircraft and drones, in an airport environment. The framework creates a new Convolutional Neural Network which adapts to the unique characteristics of small flying objects. It also exploits the spatial-temporal information, as well as post-processing, to improve the performance. The proposed framework is validated on an airport dataset and Drone-vs-Bird public dataset. The results show that the framework can not only perform object detection in real-time, but also surpass the performance of state-of-the-art models in both datasets by a large margin.
Favorable cervical cancer mortality-to-incidence ratios of countries with good Human Development Index rankings and high health expenditures
Authors: Shen Tzutsen , Long Chengyu , Wu Mingping 
Published: March 2023

Abstract
Background Cervical cancer is highly preventable. The mortality-to-incidence ratio (MIR) is a marker that reflects the available screening interventions and clinical outcomes of cancer treatments. The association between the MIR for cervical cancer and cancer screening disparities among countries is an interesting issue but rarely investigated. The present study sought to understand the association between the cervical cancer MIR and the Human Development Index (HDI).
Methods Cancer incidence and mortality rates were obtained from the GLOBOCAN database. The MIR was defined as the ratio of the crude mortality rate to the incidence. We used linear regression to analyze the correlation of MIRs with the HDI and current health expenditure (CHE) in 61 countries selected based on data quality.
Results The results showed lower incidence and mortality rates and MIRs in more developed regions. In terms of regional categories, Africa had the highest incidence and mortality rates and MIRs. The incidence and mortality rates and MIRs were lowest in North America. Furthermore, favorable MIRs were correlated with a good HDI and high CHE as a percentage of gross domestic product (CHE/GDP) (both p < 0.0001).
Conclusions The MIR variation for cervical cancer is associated with the ranking of the health system and health expenditure, further supporting the role of cancer screening and treatment disparities in clinical outcomes. The promotion of cancer screening programs can reduce the cervical cancer global incidence and mortality rates and MIRs.
Pythagorean Fuzzy MCDM Method in Renewable Energy Resources Assessment
Authors: Chaurasiya Rishikesh , Jain Divya 
Published: March 2023

Abstract
In the current paper a novel entropy measure is proposed on PFSs. Subsequently, presented an integrated PF-SWARA-MARCOS technique for ranking the selection best alternative in MCDM problems. the objective weights are evaluated by combined entropy and score function, and subjective criteria weights are evaluated using to SWARA approach and MARCOS technique is used to rank the alternatives on PFS. At the present, the choice of suitable renewable energy resources is an enormously important challenge that has an impact on both environmental and commercial growth. To deal with the concern, several authors have concentrated on selecting a necessary energy resource by adopting a decision-making method based on numerous Pythagorean fuzzy set (PFS) methodologies. Here, in this article a methodology is the presented to identify the best RERs. A comparative discussion and analysis are presented to performance the reasonableness and consistency of the technique established to rank optimal renewable energy alternatives.
The Test–Retest Reliability and Limits of Agreement of the Balance Evaluation Systems Test (BESTest) in Youth with Intellectual Disabilities—A Pilot Study
Authors: Bahiraei Saeid , Hosseini Elham , Lou Rahman Amiri Jomi 
Published: March 2023

Abstract
Clinical tests for the assessment of postural balance in people with intellectual disabilities have been the most commonly used single-item tests or multi-item tests, but new tests have been developed, such as the BESTest. The purpose of the study was to evaluate the test–retest reliability and limits of agreement of the Balance Evaluation Systems Test (BESTest) in youth with intellectual disabilities. A descriptive cross-sectional study was conducted with 65 youth (ages 16–25 years) with intellectual disabilities. The BESTest (27 items) was completed twice by the participants. Intraclass correlation coefficients (ICC), 95% confidence intervals (CIs), and standard error of measurement (SEM) were calculated to determine the test–retest reliability of the BESTest. The BESTest overall scores' test-retest reliability was rated as excellent (0.75). Stability limits/verticality, reactive fair to good (≥ 0.40–<0.75) and biomechanical constraints, transitions/anticipatory, transitions/anticipatory, sensory orientation, and stability in gait excellent (≥ 0.75). Current evidence suggests that children with intellectual disabilities have impaired postural balance. However, there appears to be a lack of assessment tools that reliably evaluate the postural balance of this population. The results from this investigation suggest that the BESTest provides "excellent reliability" (≥ 0.75) to assess postural balance in youth with intellectual disabilities.
Decomposition of drivers and identification of decoupling states for the evolution of carbon emissions from energy consumption in China
Authors: Wang Yuze , Mo Shouyi , Zhang Chenjun , Zhi Jiaqi , Li Chenchen 
Published: March 2023

Abstract
As the world's largest energy consumer, China's carbon emission reduction efforts play a pivotal role in achieving the world's climate change goals. Identifying the key factors driving the evolution of China's carbon emissions and understanding the contrasting situation of carbon emissions and economic growth are of great practical significance for China to effectively control the growth of carbon emissions and scientifically formulate carbon emission reduction policies. This paper analyzes the drivers of China's carbon emissions at the national and provincial levels using the LMDI model, and analyzes the relationship between China's economic growth and carbon emissions using the Tapio decoupling index, based on the measurement of China's carbon emissions from energy consumption during 2003–2020. Further, the paper combines the Tapio model with the LMDI model to analyze the key factors affecting the decoupling index of carbon emissions in China. The conclusions show that China's carbon emissions grow at an average annual rate of 4.04% from 2003 to 2020, and show a high growth trend until 2013, while the growth rate is more moderate after 2013. The R&D scale effect, urbanization effect, and population scale effect are the factors driving the growth of China's carbon emissions; while the energy structure effect, energy consumption industry structure effect, energy intensity effect, and R&D efficiency effect on carbon emissions inhibit the growth of China's carbon emissions during the study period. Weak decoupling is the most dominant decoupling state in China from 2003 to 2020, and the decoupling state varies significantly among provinces. Based on this, this paper obtains corresponding policy recommendations.
Chronic Constrictive Pericarditis: A rare cardiac involvement in primary Sjögren’s Syndrome
Authors: Duarte Fabiana , Oliveira Luís , Ramos Sância , Dourado Raquel , Martins Dinis 
Published: March 2023

Abstract
Background
Constrictive pericarditis represents a chronic condition of which systemic inflammatory diseases are a known, yet uncommon, cause. In primary Sjögren’s Syndrome, pericardial involvement is seldom reported, and it is usually in-association with pericardial effusion or pericarditis.
We report a case of constrictive pericarditis with an insidious course and unusual evolution related to primary Sjögren’s Syndrome. As work-up diagnosis is challenging, clinical suspicion and multimodality imaging are essential for an early diagnosis and rapid onset of treatment. Long-term outcomes remain uncertain.
To the best of our knowledge no other case linking this autoimmune disease to constrictive pericarditis have been reported.
Case presentation
We report the case of a 48 years-old male patient with moderated alcohol habits and two previous hospital admissions. The first hospitalization was due to pleural effusion and ascites, when the diagnosis of primary Sjögren´s Syndrome was performed and an empirical corticotherapy regiment was initiated.
Two-years later, he was readmitted with complains of dyspnea and abdominal distension. Hepatic peliosis was diagnosed on liver biopsy and considered secondary to glucocorticoid therapy. A localized pericardial thickening and a thin circumferential pericardial effusion was evident on thoracic computed tomography, both assumed as secondary to autoimmune disease. Diuretic therapy was adjusted, and the patient was discharged symptom-free.
He was admitted again, around 4 years later, with anasarca and right pleural effusion and at this time a constrictive pericarditis was diagnosed. A partial pericardiectomy was successfully performed.
Since then, although not completely asymptomatic the patient referred clinical improvement but still with a need for baseline diuretic therapy.
Conclusion
Albeit uncommon, connective tissue disorders, such as primary Sjögren’s Syndrome, should be considered as a cause of constrictive pericarditis, particularly in young patients without other classical risk factors for constriction.
A primary Sjögren´s Syndrome diagnosis with a likely association with constrictive pericarditis represents an interesting and challenging case attending to its rarity in modern clinical practice. A high clinical awareness and multimodal cardiac imaging are essential in earlier recognition and treatment approach.
Pathway-specific polygenic risk scores correlate with clinical status and Alzheimer’s-related biomarkers
Authors: Schork Nicholas J. , Elman Jeremy A. 
Published: March 2023

Abstract

Background:APOEis the largest genetic risk factor for sporadic Alzheimer’s disease (AD), but there is a substantial polygenic component as well. Polygenic risk scores (PRS) can summarize small effects across the genome but may obscure differential risk associated with different molecular processes and pathways. Variability at the genetic level may contribute to the extensive phenotypic heterogeneity of Alzheimer’s disease (AD). Here, we examine polygenic risk impacting specific pathways associated with AD and examined its relationship with clinical status and AD biomarkers of amyloid, tau, and neurodegeneration (A/T/N).Methods:A total of 1,411 participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) with genotyping data were included. Sets of variants identified from a pathway analysis of AD GWAS summary statistics were combined into clusters based on their assigned pathway. We constructed pathway-specific PRSs for each participant and tested their associations with diagnostic status (AD vs cognitively normal), abnormal levels of amyloid and ptau (positive vs negative), and hippocampal volume. TheAPOEregion was excluded from all PRSs, and analyses controlled forAPOE-ε4 carrier status.Results:Thirteen pathway clusters were identified relating to categories such as immune response, amyloid precursor processing, protein localization, lipid transport and binding, tyrosine kinase, and endocytosis. Eight pathway-specific PRSs were significantly associated with AD dementia diagnosis. Amyloid-positivity was associated with endocytosis and fibril formation, response misfolded protein, and regulation protein tyrosine PRSs. Ptau positivity and hippocampal volume were both related to protein localization and mitophagy PRS, and ptau positivity was additionally associated with an immune signaling PRS. A global AD PRS showed stronger associations with diagnosis and all biomarkers compared to pathway PRSs, suggesting a strong synergistic effect of all loci contributing to the global AD PRS.Conclusions:Pathway PRS may contribute to understanding separable disease processes, but do not appear to add significant power for predictive purposes. These findings demonstrate that, although genetic risk for AD is widely distributed, AD-phenotypes may be preferentially associated with risk in specific pathways. Defining genetic risk along multiple dimensions at the individual level may help clarify the etiological heterogeneity in AD.
Passive Performance Evaluation and Validation of a Viscous Impeller Pump for Subpulmonary Fontan Circulatory Support
Authors: Yang Weiguang , Conover Timothy , Giridharan Guruprasad , Figliola Richard , Marsden Alison , Rodefeld Mark 
Published: March 2023

Abstract
Patients with single ventricle defects undergoing the Fontan procedure eventually face Fontan failure. Long-term cavopulmonary assist devices using rotary pump technologies are currently being developed as a subpulmonary power source to prevent and treat Fontan failure. Low hydraulic resistance is a critical safety requirement in the event of pump failure (0 RPM) as a modest 2 mmHg cavopulmonary pressure drop can compromise patient hemodynamics. The goal of this study is therefore to assess the passive performance for a viscous impeller pump (VIP) we are developing for Fontan patients, and validate flow simulations against in-vitro data. Two different blade heights (1.09 mm vs 1.62 mm) and a blank housing model were tested using a mock circulatory loop (MCL) with cardiac output ranging from 3 to 11 L/min. Three-dimensional flow simulations were performed and compared against MCL data. In-silico and MCL results demonstrated a clinically insignificant pressure drop of $<$ 2 mmHg at a cardiac output of 7 L/min for both blade heights. There was good agreement between simulation and MCL results for pressure loss (mean difference -0.23 mmHg 95% CI [0.24 -0.71]). Compared to the blank housing model, low wall shear stress area and oscillatory shear index on the pump surface were low, and mean washout times were within 2 seconds. This study demonstrated the low resistance characteristic of current VIP designs in the failed condition that results in clinically acceptable minimal pressure loss with low risk of thrombosis.
Health Financing Challenges Among ASEAN: A Systematic Review
Authors: Lim Ming Yao , Kamaruzaman Hanin Farhana , Wu Olivia , Geue Claudia 
Published: March 2023

Abstract
Background Universal Health Coverage (UHC) has received much attention and many countries are striving towards achieving it. The Southeast Asian region in particular, comprises many developing countries with limited resources, exacerbating challenges around achieving UHC. This paper aims to specifically explore the health financing challenges these countries face in achieving UHC via a systematic review approach and formulate a set of recommendations that will be useful for policy makers.
Methods The systematic review followed the guidelines as recommended by PRISMA. Narrative synthesis approach was used for data synthesis, followed by identification of common themes.
Results The initial search returned 160 articles and a total of 32 articles were included after the screening process. The identified challenges in health financing towards achieving UHC in the Southeast Asian region are categorized into six main themes, namely 1) Unsustainability of revenue raising methods, 2) Fragmented health insurance schemes, 3) Incongruity between insurance benefits and people’s need, 4) Political and legislative indifference, 5) Intractable and rapidly rising healthcare cost, 6) Morally reprehensible behaviours.
Conclusions The challenges identified are diverse and therefore require a multifaceted approach. Regional collaborative efforts between countries will play an important role for the progress towards UHC as well as narrowing the inequity gap. At national level, individual countries need to work towards sustainable health financing strategies by leveraging on innovative digital technologies and constantly adapting to dynamic health trends.
Registration This study is registered with PROSPERO, under registration number CRD42022336624
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Outcomes in patients with chronic lymphocytic leukemia and TP53 aberration who received first line ibrutinib: a nationwide registry study from the Italian Medicines Agency
Authors: Rigolin Gian Matteo , Olimpieri Pier Paolo , Summa Valentina , Celant Simone , Scarfò Lydia , Tognolo Lucia , Ballardini Maria Pia , Urso Antonio , Sessa Mariarosaria , Gambara Silvia , Cura Francesca , Fortini Monica , Ghia Paolo , Cuneo Antonio , Russo Pierluigi 
Published: March 2023

Abstract
In this analysis we describe the effectiveness of first-line ibrutinib in 747 patients with chronic lymphocytic leukemia (CLL) and TP53 aberrations in a nationwide study with a 100% capture of patients who received the study drug. Median age was 71 years (range 32-95). An estimated treatment persistence rate of 63.4% (95% CI 60.0%-67.0%) and survival rate of 82.6% (95% CI 79.9%-85.4%) were recorded at 24 months. Disease progression or death were the reasons for discontinuation in 182/397 patients (45.8%). A higher risk of treatment discontinuation was found to be associated with age, ECOG-PS and pre-existing heart disease, whereas ECOG≥1, age≥70 years and male sex were associated with an increased risk of death. Median post-progression overall survival (OS) was 12.2 months (95% CI 9.2-22.0). Post-discontinuation median OS in patients who discontinued ibrutinib for other reasons was not reached (95% CI 42.3 months – NA).
Ibrutinib was an effective first-line treatment for CLL and TP53 aberrations in patients treated at large academic centers and community practice hospitals. Clinical characteristics at baseline may influence the effectiveness of ibrutinib, whereas the experience of prescribing centers and multi-hit or single-hit TP53 aberrations had no impact on outcome in this high-risk population.
Early breeding site arrival of a migratory tropical seabird correlates with large-scale climatic phenomena in the North Atlantic
Authors: Campioni Letizia , Madeiros Jeremy , Becciu Paolo 
Published: March 2023

AbstractClimate change and weather variability are having global impacts on the lives of organisms, particularly on high-trophic level predators such as pelagic seabirds. In the North Atlantic, migratory seabirds are expected to respond to climate variability by adjusting their seasonal events, including the timing of migration and arrival at the breeding site. The timing of these events may be influenced by large-scale atmospheric phenomena like the North Atlantic Oscillation (NAO) and the Atlantic Multi-decadal Oscillation (AMO). The White-tailed Tropicbird (Phaethon lepturus) is a wide-spread tropical migratory seabird breeding at its Atlantic northernmost edge of distribution range in Bermuda Islands (32° 17' 58'' N, 64° 47' 25'' W). Using data from eBird, an online database of bird observations where expert and amateur birdwatchers can report their sightings, we explored trends in Tropicbird first annual observation (proxy for bird arrival time) at the Bermuda breeding ground from 1953 to 2023. Specifically, we examined the relationship between the arrival time of the Tropicbird at its breeding site and the NAO and AMO. We show that the progressive early arrival at the breeding site (20–25 days in advance) of Tropicbirds over the last 70 years positively correlated with the NAO and AMO Indices. This suggests that this tropic seabird breeding in the North Atlantic may be responding to climate-induced changes affecting the Atlantic Ocean. Our findings highlight the fundamental contribution of citizen-science data for ecological long-term studies to understand animals' responses to a changing world.