bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid Adaptation to Prevent Drug Use (RAPD): protocol of a pilot randomized trial to enhance the impact of an evidence-based intervention for youth
Authors: Eisman Andria B. , Koffkey Christine , Partridge Robert T. , Brown Suzanne , Kim Bo 
Published: January 2025

Abstract

Background
Drug use trends change rapidly among youth, leaving intervention experts struggling to respond promptly. Delays in responses can lead to preventable morbidity and mortality. The COVID-19 pandemic underscored the need for implementation science to facilitate rapid, equitable responses using existing treatment and prevention efforts. Existing, widely adopted evidence-based interventions (EBIs; e.g., the Michigan Model for Health™: MMH) are well suited to address emerging drug trends. We have a critical need to advance implementation strategies to optimize system responsiveness to these emerging drug issues. This research aims to design and test implementation strategies to (1) improve the responsiveness of school-based EBIs in addressing urgent issues and (2) find ways to support teachers in implementing updated EBIs, attending to unique considerations of schools serving economically disadvantaged students.

Methods
The research aims are as follows: aim 1: identify implementation gaps and best practices using After Action Review (a reflective process used by health organizations in responding to emergent public health events) using qualitative methods. Aim 2: design and pilot test RAPD (Rapid Adaptation to Prevent Drug use) based on aim 1 findings. RAPD refers to a novel set of implementation strategies designed to enhance the capacity of an existing, widely adopted evidence-based universal prevention curriculum (MMH) to respond to emerging drug issues among youth. We will pilot test RAPD in ten middle schools serving diverse student populations using a two-group, mixed method, cluster randomized controlled trial design. Aim 3: assess the costs and benefits of RAPD from multiple partner perspectives using a mixed methods approach.

Discussion
This study focuses on designing and deploying implementation strategies to reduce the detrimental impact of emerging drugs and provide an infrastructure to make future adaptations that can be applied in other contexts. After Action Review (AAR) provides a valuable opportunity to review the statewide response to past drug use events, specifically the vaping crisis, using the MMH curriculum, which can systematically guide implementation strategy selection and deployment to meet identified gaps. The rationale for the proposed research is that designing and testing RAPD will advance implementation science in responding to urgent public health events and ensure equitable responses across youth populations.

Trial registration
ClinicalTrials.gov NCT05806840.
Antimicrobial use in animal farms in Egypt: rates, patterns, and determinants
Authors: ElSayed Nada , Amine Amira , El-Attar Laila , Amin Mohamed E. K. 
Published: January 2025

Abstract

Background
While antimicrobial use (AMU) in human healthcare has received significant attention as a key driver of antimicrobial resistance (AMR), less emphasis has been placed on AMU practices and attitudes in animal husbandry. To address this gap, this study examines the patterns and underlying drivers of AMU on animal farms.

Methods
A survey instrument was distributed to farm staff in 150 animal farms across 15 Egyptian governorates. Farms were selected from a list curated by a private platform specialized in Egypt’s poultry and cattle industry. An online search was conducted to identify additional farms not included in the list or when the contact information was unavailable. The instrument covered key items related to AMU including types of antimicrobials used, indications, their perceived benefits, and the feed conversion ratio (FCR). Using the theory of reasoned action (TRA) as a guiding theoretical framework, this study assesses key factors influencing the AMU behavior of farm personnel.

Results
Out of 150 farm personnel invited to fill out the survey forms, 111 (74%) responded and agreed to participate. All surveyed personnel reported using antimicrobials, and almost two-thirds (65%) reported using them for non-therapeutic purposes. Non-therapeutic use of antimicrobials, however, had no impact on FCR across all farm types (poultry, cattle, and mixed). The most used antimicrobials were penicillins (81%), followed by macrolides (78%) and tetracyclines (72%). Half of the studied farms reported using colistin, with more than half of this segment (55%) reporting using it for non-therapeutic purposes. Farm personnel’s AMU behavior was associated with the TRA constructs: perceived benefits of antimicrobials (attitude) and perceived AMU behavior in other farms (subjective norm).

Conclusions
Antimicrobials are unanimously used in animal farms in Egypt, including those classified as last-resort options, such as colistin. Using antimicrobials for disease prevention or growth promotion did not decrease the FCR. Interventions that target the farm personnel’s attitude and the subjective norm should be carried out to change their behavior regarding the use of antimicrobials. Egyptian guidelines for AMU in livestock are urgently needed, along with training to raise awareness of AMR and safer practices. The use of last-resort drugs like colistin should be banned in animal farming, and national surveillance systems should monitor AMU and AMR trends.
Hematological parameters in pediatric pulmonary and extrapulmonary tuberculosis in Vietnam: a prospective observational study
Authors: Nguyen-Huu Chau Duc , Tran Thi Hanh Chan , La Thi Hong Nhung , Nguyen Van-Tuy 
Published: January 2025

Abstract

Background
Tuberculosis in children remains a significant public health issue in Vietnam. This study aims to describe the clinical and paraclinical characteristics of children with pulmonary and extrapulmonary tuberculosis and to evaluate the value of certain hematological parameters in differentiating between these two forms.

Methods
This prospective observational study was conducted on 36 children diagnosed and treated for tuberculosis at Hue Central Hospital. Clinical and paraclinical characteristics were compared between pulmonary and extrapulmonary tuberculosis. The ROC curve, sensitivity, and specificity were used to compare the diagnostic value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and Systemic Immune-Inflammation Index (SII) in differentiating pulmonary from extrapulmonary tuberculosis.

Results
Of the 36 children with tuberculosis in the study group, 58.3% had pulmonary tuberculosis and 41.7% had extrapulmonary tuberculosis. There were significant differences between pulmonary and extrapulmonary tuberculosis in terms of gender distribution (p = 0.037), family history (p = 0.008), fever (p = 0.001), malnutrition (p = 0.008), and night sweats (p = 0.027). Pulmonary tuberculosis had significantly higher levels of inflammatory markers such as white blood cells, neutrophils, ESR, and CRP compared to extrapulmonary tuberculosis. The NLR and SII indices showed good discriminatory value, while the PLR index showed acceptable discriminatory value when comparing pulmonary and extrapulmonary tuberculosis. The SII index had the best diagnostic value with an AUC of 0.832, sensitivity of 66.7%, and specificity of 86.7%.

Conclusions
Hematological indices calculated from the complete blood count (NLR, PLR, SII) have good value in differentiating between pulmonary and extrapulmonary tuberculosis in children, with the SII index having the best value.
Heterozygous Eif4nif1 Stop-Gain Mice Replicate the Primary Ovarian Insufficiency Phenotype in Women
Authors: Moriwaki Mika , Liu Lihua , James Emma R , Tolley Neal D , O’Connor Ashley M , Emery Benjamin , Aston Kenneth Ivan , Campbell Robert A , Welt Corrine K 
Published: January 2025

Abstract
We created the c.1286C&gt;G stop-gain mutation found in a family with primary ovarian insufficiency (POI) at age 30 years. The Eif4enif1 C57/Bl6 transgenic mouse model contained a floxed exon 10-19 cassette with a conditional knock-in cassette containing the c.1286C&gt;G stop-gain mutation in exon 10. The hybrid offspring of CMV-Cre mice with Eif4enif1WT/flx mice were designated Eif4enif1WT/Δ for simplicity. A subset of female heterozygotes (Eif4enif1WT/Δ) had no litters. In those with litters, the final litter was earlier (5.4 ± 2.6 vs 10.5 ± 0.7 months; P = .02). Heterozygous breeding pair (Eif4enif1WT/Δ × Eif4enif1WT/Δ) litter size was 60% of WT litter size (3.9 ± 2.0 vs 6.5 ± 3.0 pups/litter; P &lt; .001). The genotypes were 35% Eif4enif1WT/flx and 65% Eif4enif1WT/Δ, with no homozygotes. Homozygote embryos did not develop beyond the 4- to 8-cell stage. The number of follicles in ovaries from Eif4enif1WT/Δ mice was lower starting at the primordial (499 ± 290 vs 1445 ± 381) and primary follicle stage (1069 ± 346 vs 1450 ± 193) on day 10 (P &lt; .05). The preantral follicle number was lower starting on day 21 (213 ± 86 vs 522 ± 227; P &lt; .01). Examination of ribosome protected mRNAs demonstrated altered mRNA expression. The Eif4enif1 stop-gain mice replicate the POI phenotype in women based on an earlier end to reproduction due to oocyte loss. The unique mouse model provides a platform to study regulation of protein translation across oocyte and embryo development in mammals.
LABOR AND EMPLOYMENT OF YOUTH IN THE ARCTIC ZONE OF RUSSIA: SOCIO-CULTURAL AND ECONOMIC ASPECTS (CASE OF ARKHANGELSK AGGLOMERATION)
Authors: Chizhova Lyudmila A. , Lets Olga V. , Podoplekin Andrey O. 
Published: January 2025

Background. The article is describes the problems and peculiarities of labor and employment of the younger generation in the Arctic regions of Russia in the context of modern political, economic and socio-cultural reality. Special attention is paid to the results of a sociological study of the youth of the Arkhangelsk agglomeration, where the risks of job instability are quite acute, which in turn leads to high rates of migration attitudes.
Purpose. The authors aim to reveal the socio-cultural and economic aspects of the problem of labor and employment of young people living in the Russian Arctic.
Methodology. The main research methods used were content analysis of monographic and periodic scientific publications, statistical analysis of socio-economic indicators, and sociological surveys of representatives of the younger generation.
Results. It has been established that the main reasons for the migration attitudes of the younger generation of the Arctic region are both the lack of employment opportunities, career growth and decent earnings, as well as dissatisfaction with the “future” and “cultural environment”. At the same time, the authors are convinced that in modern conditions, the successful socio-economic development of the Arctic territories depends on ideological and political stability, life strategies of young people, identity and emotional connection with the territory of residence.
Practical implications. The results of the study can be applied in the practice of regional authorities responsible for the implementation of youth policy, including in the field of vocational guidance, employment and employment.
LEGAL REGULATION OF STATE SUPPORT MEASURES FOR RUSSIAN BANKS AT THE PRESENT STAGE
Authors: Pushkina Lyudmila G. 
Published: January 2025

The article examines the legal regulation of state support measures for banks of the Russian Federation at the present stage. The adopted normative legal acts aimed at adapting credit institutions to long-term structural changes in the banking sector are analyzed. Special attention is paid to the measures taken in 2022 in connection with the changing geopolitical situation and the imposition of sanctions. The work evaluates the effectiveness of these measures and their impact on the activities of credit institutions. In conclusion, the author concludes that it is necessary to introduce a new regulatory document that will regulate the process of creating and publishing doctrinal materials of the Central Bank, including those that the Central Bank develops on its own initiative.
Purpose. The purpose of the study is to identify current problems of legal regulation of state support measures for banks of the Russian Federation.
Methods. To achieve this goal, the dialectical method of cognition was used in the framework of the study, which provides a scientific approach to the study of phenomena, as well as scientific methods of analysis and synthesis.
Results. The main problems of the legislation of the Russian Federation in the field of legal regulation of state measures to support banks are identified. To increase the effectiveness of this area, ways to improve the law-making activities of the Central Bank of the Russian Federation are proposed.
Beyond Growth: A Provincial-Level Assessment of the Doughnut Economy's Potential in Indonesia
Authors: Rahma Hania , Fauzi Akhmad 
Published: January 2025

The focus on a growth-oriented development paradigm has led to unsustainable outcomes such as environmental degradation, resource depletion, increased inequality, and compromised social well-being. An alternative approach known as the Doughnut Economy has emerged, offering a new economic development model that aims to guide humanity towards staying within planetary boundaries. The Doughnut model visualizes sustainable development with an ecological ceiling as the outer limit and a social foundation as the inner boundary. This study attempts to create a Doughnut Economy Index for 34 provinces in Indonesia, categorizing them into four groups to assess how well they meet societal needs while remaining within planetary limits. The index, derived from a simple formula, yields two indices: social performance and ecological damage. The research reveals that only three out of the 34 provinces in Indonesia fall within the safe zone of the Doughnut model. Shortfall issues are prevalent in Eastern Indonesian provinces like Papua, Maluku, and Nusa Tenggara Islands, while overshoot concerns are more prominent in provinces in Kalimantan and Java & Bali Islands.

Keywords: Growth-oriented paradigm, Doughnut Economy, sustainable development, regional development, Doughnut Economy Index
Climate Change Management – Legislative Challenges in the Context of Sustainability
Authors: Kudeikina Inga , Kaija Sandra 
Published: January 2025

The research deals with problems arising out of recognising climate change and introducing climate change management in legislation in order to ensure its conformity with the needs of sustainable development.
The objective of the research is to explore the legal framework in the context of climate change management and to find out ways of its improvement in order to achieve the efficient use of natural resources, so mitigating the adverse impacts of climate change and fostering the sustainable development of society.
The research has employed descriptive, analytical, deductive and inductive methods. These methods have been used to analyse laws and the opinions of legal scholars and formulate conclusions and suggestions.

Keywords: climate change, climate neutrality, climate policy, responsibility
Balancing Economic, Environmental, and Technological Systems for Sustainable Agricultural Development in Romania
Authors: Cristian BUZOIANU Ovidiu Andrei , IACOB Oana , Mihai MATEESCU Vicențiu , BURLACU Sorin 
Published: January 2025

The aim of this research is to ascertain and evaluate the optimal equilibrium in the interaction of four critical systems: social, economic, technological and environmental. This will enable a functional process that is both dynamic and adaptable within the context of long-term sustainable development. The research centers on significant enduring obstacles, such as the expansion of the global population, strain on natural resources, and global warming, which establish a fresh framework for necessary measures to attain this equilibrium.
The research methodology employed in this study encompasses an extensive examination of existing literature, along with the analysis of case studies and statistical data. The objective is to evaluate the influence of demographic and environmental factors on agriculture and rural regions. The analysis centers on the following factors: worldwide population growth, urbanization, escalating energy and fertilizer costs, strain on water resources, and the heightened susceptibility of crops and livestock to climate change. The study also analyzes the European Union's policies and strategies designed to address these challenges by promoting food security, sustainable resource management, and equitable territorial development.
The primary conclusions of the study suggest that while there is a persistent rise in the worldwide demand for food, the availability of food is constrained by various crucial factors. The factors encompassed in this context comprise of accelerated urbanization, escalating energy and fertilizer expenses, heightened strain on water resources, and augmented susceptibility of agriculture to climate change. Europe faces amplified challenges due to its aging population, impacting both the availability of agricultural workforce and the need for food.
This research contributes to the comprehension of the necessity for an all-encompassing and enduring approach in agricultural and rural development policy. The study emphasizes the intricate relationship among economic, environmental, human, and technological factors. It underscores the significance of a cohesive and flexible strategy to address long-term challenges and maintain a sustainable equilibrium between economic growth, environmental preservation, and human welfare.

Keywords: agriculture, sustainable development, production, Romania
Legal Dimensions of AI Contracts in Sports Talent Management: Challenges and Solutions
Authors: Ghorbani Asiabar Dr. Mojtaba , ghorbani asiabar Morteza , ghorbani asiabar Alireza 
Published: January 2025

This study examines the legal implications of artificial intelligence (AI) contracts in sports talent management, focusing on the challenges and potential solutions in this rapidly evolving field. As AI technologies increasingly permeate the sports industry, particularly in talent scouting and performance analysis, the legal framework surrounding these applications remains complex and often ambiguous. Our research employs a mixed-methods approach, combining qualitative analysis of legal precedents with quantitative data from a survey of 150 sports organizations (n = 150) across 10 countries.
Key findings indicate that 78% of surveyed organizations use AI in talent management, yet only 32% have comprehensive AI policies in place (p < 0.001). The study identifies three primary legal challenges: (1) intellectual property rights for AI-generated insights (χ2 = 15.7, p < 0.01), (2) data privacy concerns, particularly under GDPR (F = 8.3, p < 0.05), and (3) potential bias in AI decision-making (r = 0.62, p < 0.001). To address these issues, we propose a framework for AI contracts in sports that emphasizes transparency, accountability, and ethical considerations.
Our analysis reveals that organizations with robust AI policies demonstrate a 40% reduction in legal disputes related to talent management (95% CI: 32-48%, p < 0.001). Furthermore, we found a significant positive correlation between the implementation of AI ethics committees and successful talent acquisition (r = 0.71, p < 0.001).
This research contributes to the growing body of literature on AI in sports management and provides practical guidelines for sports organizations to navigate the legal landscape of AI-driven talent management. Future research directions and policy implications are discussed, highlighting the need for adaptive regulatory frameworks in this dynamic field.
Theoretical Model of Neutrino-Light Coupling in Pulsar Emissions: A Novel Approach to Wave-Particle Duality
Authors: Lopez Victor 
Published: January 2025

This paper presents a theoretical framework for understanding the
relationship between neutrinos and electromagnetic radiation in pulsar
emissions. We propose a novel model where neutrinos exhibit helical
wrapping patterns around light beams, potentially offering new insights
into wave-particle duality. The model combines classical pulsar
emission equations with quantum mechanical principles to describe
neutrino-photon interactions.
Continuation of the Theoretical Model of Neutrino-Light Coupling in Pulsar Emissions: A Novel Approach to Wave-Particle Duality
Authors: Lopez Victor 
Published: January 2025

This paper presents a theoretical framework for understanding the
relationship between neutrinos and electromagnetic radiation in pulsar
emissions. We propose a novel model where neutrinos exhibit helical
wrapping patterns around light beams, potentially offering new insights
into wave-particle duality. The model combines classical pulsar
emission equations with quantum mechanical principles to describe
neutrino-photon interactions.
Demokratiepädagogisch Agieren in (Öffentlichen) Bibliotheken
Authors: Becker Tom , Fischer Yvonne 
Published: January 2025

Zusammenfassung
Spielen Bibliotheken in demokratischen Gesellschaften eine zentrale Rolle bei der Wissensvermittlung und der Förderung gesellschaftlicher Teilhabe? Ja, denn als Orte des Dialogs agieren sie zunehmend proaktiv demokratiepädagogisch. Der Artikel beleuchtet erfolgreiche Formate, thematisiert ausgewählte Herausforderungen und bietet konkrete Ideen zur Weiterentwicklung einer erfolgreichen Demokratiearbeit von Bibliotheken.
Habitando en comunidad: voces eternizadas en el aula
Authors: Diaz Laverde Angie Nataly , Modesto Gonzalez Mariana 
Published: January 2025

Al hablar de Inclusión Educativa (IE), esta se atribuye únicamente al licenciado en educación especial y al trabajo con las personas con discapacidad (PcD); en algunos contextos, las acciones inclusivas de la IE se orientan a capacitar a los docentes para asumir la escuela inclusiva, sin embargo, se olvida y aísla de estas acciones transformadoras el rol que ejercen los habitantes primarios, los estudiantes. En este sentido, para esta investigación fue importante reconocer el papel del estudiante en los procesos de IE del municipio de Sopo-Cundinamarca, desde la apropiación y entendimiento de la alteridad y otredad, y la relación con el aprendizaje cooperativo.
La investigación se ubica en el paradigma sociocrítico, con un enfoque de Investigación Acción, planteado por Jhon Elliot, (2000). La información recolectada contó con el consentimiento informado por parte de los participantes, que fueron 420 estudiantes de las Instituciones Educativas Departamentales (IEDs) la Violeta, Rafael Pombo y CEIS (Complejo Educativo Integral de Sopó).
Se concluye, que los estudiantes reconocen las diferencias como cualidades del ser, configurando la construcción colectiva de una sociedad más inclusiva. De esta manera, se descentraliza los roles tradicionales que atienden los procesos de IE, entreviendo un espacio de participación colectiva como agentes de cambio y transformación.