bluuebunny/crossref_metadata_2025_split huggingface dataset:
MỐI LIÊN QUAN GIỮA KIẾN THỨC VÀ THỰC HÀNH DỰ PHÒNG ĐỘT QUỴ NÃO Ở 726 BỆNH NHÂN TĂNG HUYẾT ÁP, ĐIỀU TRỊ TẠI BỆNH VIỆN TRUNG ƯƠNG QUÂN ĐỘI 108
Authors: Nguyễn Văn Triệu 
Published: April 2023

Mục tiêu: Đánh giá mối liên quan giữa kiến thức và thực hành dự phòng đột quỵ não ở bệnh nhân tăng huyết áp.
Đối tượng và phương pháp: Nghiên cứu tiến cứu, mô tả cắt ngang có phân tích 726 bệnh nhân tăng huyết áp, điều trị tại Bệnh viện Trung ương Quân đội 108, từ tháng 06/2020 đến tháng 06/2021.
Kết quả: Trên nhóm bệnh nhân tăng huyết áp nghiên cứu, có mối tương quan mức độ yếu giữa kiến thức chung về đột quỵ não và thực hành dự phòng đột quỵ não (r = 0,278, p < 0,0001); có mối tương quan mức độ không chặt chẽ giữa kiến thức về dự phòng đột quỵ não và thực hành dự phòng đột quỵ não (r = 0,313, p < 0,0001); có mối tương quan mức độ mạnh, có ý nghĩa thống kê giữa kiến thức chung về đột quỵ não và kiến thức dự phòng đột quỵ não (r = 0,722, p < 0,0001).
ANALYSIS OF EXTERNAL FACTORS ON RURAL ECOTOURISM ENTREPRENEURSHIP (CASE STUDY IN BOGOR REGENCY OF WEST JAVA)
Authors: Purba Indra Setiawan , Avenzora Ricky , Anggraini Eva , Darusman Dudung 
Published: April 2023

The entrepreneurship aspect will determine the success of the development and development of rural ecotourism. Rural ecotourism products and services must be created and packaged by entrepreneurs in an attractive and highly competitive manner so that tourists are interested in consuming them. This study aimed to analyze the external factors that affect entrepreneurial capacity in rural ecotourism. The research location was in four tourist villages in Bogor Regency, namely Ciasihan, Sirnajaya, Watesjaya and Pabuaran Villages. Primary data was obtained through filling out a list of questions by respondents using a closed-ended questionnaire by applying the “one score one indicator scoring” system pattern . Data analysis was carried out in a quantitative descriptive manner based on the average value of each criterion/indicator. Analysis of causality between variables is carried out using logistic regression analysis. The results show that the external factors that significantly affect the performance of rural ecotourism entrepreneurship are dominated by social aspects (seven factors) and some aspects of the entrepreneurship ecosystem, namely 1) market, 2) finance and 3) business culture. The highest odds ratio is in the social interaction variable, which is 5.459, while the lowest odds ratio is in the group solidarity variable, which is 0.323. With the odds ratio of social interaction of 5.459, it can be interpreted that if social interaction in the tourist village increases, it will tend to cause the success in entrepreneurship 5.459 times higher than in the absence of social interaction.
Análise espaço-temporal da dengue no município de Belém do Pará, Norte do Brasil
Authors: Silva Brenda Caroline Sampaio da , Guimarães Ricardo José de Paula Souza e , Godoy Bruno Spacek 
Published: April 2023

O objetivo deste trabalho foi identificar as áreas de maior risco para a dengue em Belém do Pará, através da distribuição espaço-temporal dos casos no período de 2010 a 2019, delineando o direcionamento de intervenções mais urgentes. Trata-se de um estudo ecológico que buscou análises mais finas em uma região carente de estudos epidemiológicos para a dengue atualizados. Para isso, utilizaram-se os casos da doença e dados socioambientais que serviram para o cálculo de taxas de incidência, a construção de um Índice de Condição de Vida e a realização de análises espaço-temporais através das técnicas do Estimador Bayesiano Local, Índice de Moran Global e Local, Estimador de Densidade de Kernel e Metodologia de Varredura (Scan). Os resultados observados foram: altas taxas de incidência de dengue e aglomerados significativos em Belém, mesmo nas áreas de melhores condições socioambientais, como é o caso da região sul do município, e no distrito de Mosqueiro (área turística). O Scan apontou cluster espaço-temporal no período de 2010 a 2012 sugerindo entrada de novos sorotipos. Esses resultados mostraram que as ações devem ser direcionadas para maximizar a relação custo-eficácia dos controles em comparação com intervenções aleatórias, além da importância de um monitoramento contínuo para a doença, tendo em vista que Belém possui condições facilitadoras ao vetor.
Idling and Short-circuit Analysis of a Three-phase Power Transformer Represented by a Scheme with Distributed Parameters and П line Scheme in the Electrical Network
Authors: Marković N. , Bjelić S. , Marković F. , Jakšić U. 
Published: April 2023

Aims: The paper presents a simulation of a theoretical model of electromagnetic extreme regimes, idling and short circuit, in a three-phase power transformer. The main goal of this paper is to show in a quality way that the computer simulation of the obtained theoretical model using the software package MATLAB Simulink confirms the possibility of analyzing the extreme modes of transformers.
Methodology: To solve the problem of the presence of a transformer as an element of power in the power system, the following are used: Analytical methods in which the transformer is presented as a network element - usually as a quadripole, numerical programming that includes dynamic programming and independent variables, and combined programming with integer values. In the process simulation on elements with given parameters and frequency, a comparison of the substitution schemes used so far in the theory of electric circuits is performed. The accuracy of these theoretical models can be confirmed by voltage and current diagrams in the adapted software package MATLAB Simulink.
Conclusion: The presented theoretical model and the applied algorithm in the simulation are universal and can be used for different states in which a three-phase power transformer can be found. Problems that occur in the analysis of transient processes in electrical networks where the element is a transformer can be minimized using simulation methods. Changing any parameter in the electrical circuit requires a new calculation of the condition of the circuit from the very beginning due to the new initial conditions. Analytical methods combined with the simulation method were used in the research of extreme regimes, such as idling and short circuit. The verified simulation method realized using the adapted MATLAB Simulink program had a threefold purpose: to serve the calculation and simulation of quantities that can be obtained by testing or measuring, to establish the original algorithm and to verify the proposed method. Also, this type of simulation can replace the idle and short circuit test.
Evaluation of Hormone Quantification as an Orientation Screening in the Diagnosis of Hormone-Dependent Breast Cancers in Women in Abidjan, Côte d'Ivoire
Authors: Djéda Franck Arnaud Gnahoré , Gbonon Valérie Carole M’Bengue , Diplo Flore Bernadette , Coulibaly Safiatou , Osseni Akandji , Sekongo Mamadou , N’Guessan Jean David , Djaman Joseph Allico , Dosso Mireille 
Published: April 2023

Aim: Estrogens and progesterone are essential for breast development in women. Paradoxically they promote the development of breast cancer, through the stimulation and proliferation of cells by the action of hormone receptors. In Côte d'Ivoire, more than half of all diagnosed cases of breast cancer are hormone-dependent. Because of the link between female hormones and breast cancer, the consideration of certain factors, such as the period of influence of hormones (estrogen and progesterone) as well as their quantification, could be considered in orientation screening for hormone-dependent breast cancer.
Methodology: A case-control study conducted at the Cancerology Department of the Treichville University Hospital, the National Blood Transfusion Centre, and the Pasteur Institute of Côte d'Ivoire recruited 85 participants, including 39 cases and 46 non-menopausal and menopausal controls. Socio-demographic information and the participants' clinical status were collected through a questionnaire and consultation of the medical file. Blood samples were taken in dry red tubes with a coagulation activator on the day of inclusion for postmenopausal women and during the follicular phase for non-menopausal women (between days 4 and 7 of the menstrual cycle). The quantification of hormones (estrogen, progesterone, FSH, and LH) was performed by immunoassay on the Cobas e411 Analyser®.
Results: Postmenopausal cases had early menarche (13 years) and late menopause (52.46 years) compared to controls and also had slightly higher mean plasma oestradiol 2 and progesterone levels (P=0.04; P=0.017). Among these cases, those with ER+ tumors had slightly higher mean plasma oestradiol-2 levels (15.28 pg/mL) than those with ER- tumors (9.20 pg/mL) (P=0.03).
Conclusion: The epidemiological investigation and the quantification of hormones in the participants' blood plasma revealed a positive association between the period of influence of these hormones, their concentrations, and hormone-dependent breast cancer in postmenopausal women.
Dosimetric Comparison of Stereotactic Body Radiotherapy in Lung Cancers: CyberKnife Versus Helical Tomotherapy Versus Volumetric Modulated Arc Therapy
Authors: Kekilli E. , Ertan F. , Çeşmeci A. B. , Adaş G. Y. , Ertaş G. , Göksel F. 
Published: April 2023

Aim: Stereotactic body radiotherapy (SBRT) is widely used in the treatment of early- stage lung cancer. There are several SBRT techniques. We aimed to compare three planning techniques: CyberKnife (CK), Helical Tomotherapy (HT), and Volumetric Modulated Arc Therapy (VMAT).
Materials and Methods: This study included 15 patients with early-stagelung cancer who were treated in our clinic. For this study, the images obtained were recontoured and replanned in CK, HT, and VMAT. Treatment plans were compared in terms of target volume and organ-at-risk doses.
Results: The HT plan differed significantly from the other plans in terms of conformity (CI), and gradient indexes (GI) (p<0.001). There was a significant difference between the plans in terms of homogeneity indexes (HI) favoring HT (p<0.001). VMAT plan reduced the monitor unit per fraction and beam on time per fraction values (p < 0.001). The lowest lung V5 (22.7%, p = 0.046), Dmax, and the dose of 5 cc of trachea (499.4 cGy vs 252.4 cGy; p=0.017, p=0.034) and esophagus (673.9 cGyvs237.3 cGy; p=0.014 and p=0.08) were observed with the VMAT plan.
Conclusions: All plans met the organ-at-risk dose constraints and target volume doseswith acceptable limits. Each clinic should select an appropriate technique based on the available resources and experience.
Virtual interviewing in the MedPhys match: Experiences of applicants and programs
Authors: Juang Titania , Landers Angelia , Rodrigues Anna E. , Schubert Leah , Hendrickson Kristi R. G. 
Published: April 2023

AbstractPurposeThe purpose of this survey study is to compare the experiences of programs and applicants in the MedPhys Match (MPM) in the 2020–21 match cycle with experiences reported from previous match cycles. The 2020–21 match cycle was unique in that recruitment and interviewing were almost exclusively virtual during the COVID‐19 pandemic.MethodsA survey was sent to all applicants and programs registered for the 2020–21 MPM. Survey questions asked about the pre‐interview screening, interview, ranking, and post‐match stages of the residency match process. Survey data were analyzed using graphical methods and spreadsheet tools.ResultsAdvantages and disadvantages to the virtual interviewing experience were reported by applicants and program directors (PDs). The advantages included reduced cost and greater scheduling flexibility with fewer scheduling conflicts, allowing applicants to consider more programs. These advantages greatly outweighed the disadvantages such as the inability to meet faculty/staff and current residents in person and gauge the feel of the program. PDs recognized the advantages of minimal costs and time savings for applicants. Programs reported it was difficult to convey workplace culture and the physical environment and to gauge personality and interpersonal skills of the applicants.ConclusionThe virtual interviewing environment for residency recruitment in medical physics is strongly preferred by applicants over required in‐person interviews. The advantages identified by applicants outweigh the disadvantages, allowing applicants to feel confident in their ranking decisions and overall satisfied with their match results. PDs acknowledge the greater equity of access to interviews for applicants in the virtual environment, however, they are overall less satisfied with their ability to showcase their program's strengths and to assess the personality of applicants. Caution is urged when considering a hybrid interview model to ensure fair assessments that do not depend on whether an applicant chooses to accept an optional in‐person interview or site visit.
“Brain age” predicts disability accumulation in multiple sclerosis
Authors: Brier Matthew R. , Li Zhuocheng , Ly Maria , Karim Helmet T. , Liang Leda , Du Weixin , McCarthy John E. , Cross Anne H. , Benzinger Tammie L. S. , Naismith Robert T. , Chahin Salim 
Published: April 2023

AbstractObjectiveNeurodegenerative conditions often manifest radiologically with the appearance of premature aging. Multiple sclerosis (MS) biomarkers related to lesion burden are well developed, but measures of neurodegeneration are less well‐developed. The appearance of premature aging quantified by machine learning applied to structural MRI assesses neurodegenerative pathology. We assess the explanatory and predictive power of “brain age” analysis on disability in MS using a large, real‐world dataset.MethodsBrain age analysis is predicated on the over‐estimation of predicted brain age in patients with more advanced pathology. We compared the performance of three brain age algorithms in a large, longitudinal dataset (>13,000 imaging sessions from >6,000 individual MS patients). Effects of MS, MS disease course, disability, lesion burden, and DMT efficacy were assessed using linear mixed effects models.ResultsMS was associated with advanced predicted brain age cross‐sectionally and accelerated brain aging longitudinally in all techniques. While MS disease course (relapsing vs. progressive) did contribute to advanced brain age, disability was the primary correlate of advanced brain age. We found that advanced brain age at study enrollment predicted more disability accumulation longitudinally. Lastly, a more youthful appearing brain (predicted brain age less than actual age) was associated with decreased disability.InterpretationBrain age is a technically tractable and clinically relevant biomarker of disease pathology that correlates with and predicts increasing disability in MS. Advanced brain age predicts future disability accumulation.
Protein kinetics of superoxide dismutase‐1 in familial and sporadic amyotrophic lateral sclerosis
Authors: Ly Cindy V. , Ireland Margaret D. , Self Wade K. , Bollinger James , Jockel‐Balsarotti Jennifer , Herzog Hillary , Allred Peggy , Miller Leah , Doyle Michael , Anez‐Bruzual Isabel , Trikamji Bhavesh , Hyman Ted , Kung Tyler , Nicholson Katherine , Bucelli Robert C. , Patterson Bruce W. , Bateman Randall J. , Miller Timothy M. 
Published: April 2023

AbstractObjectiveAccumulation of misfolded superoxide dismutase‐1 (SOD1) is a pathological hallmark of SOD1‐related amyotrophic lateral sclerosis (ALS) and is observed in sporadic ALS where its role in pathogenesis is controversial. Understanding in vivo protein kinetics may clarify how SOD1 influences neurodegeneration and inform optimal dosing for therapies that lower SOD1 transcripts.MethodsWe employed stable isotope labeling paired with mass spectrometry to evaluate in vivo protein kinetics and concentration of soluble SOD1 in cerebrospinal fluid (CSF) of SOD1 mutation carriers, sporadic ALS participants and controls. A deaminated SOD1 peptide, SDGPVKV, that correlates with protein stability was also measured.ResultsIn participants with heterozygous SOD1A5V mutations, known to cause rapidly progressive ALS, mutant SOD1 protein exhibited ~twofold faster turnover and ~ 16‐fold lower concentration compared to wild‐type SOD1 protein. SDGPVKV levels were increased in SOD1A5V carriers relative to controls. Thus, SOD1 mutations impact protein kinetics and stability. We applied this approach to sporadic ALS participants and found that SOD1 turnover, concentration, and SDGPVKV levels are not significantly different compared to controls.InterpretationThese results highlight the ability of stable isotope labeling approaches and peptide deamidation to discern the influence of disease mutations on protein kinetics and stability and support implementation of this method to optimize clinical trial design of gene and molecular therapies for neurological disorders.Trial RegistrationClinicaltrials.gov: NCT03449212.
Surface‐Engineered Vanadium Carbide MXenzyme for Anti‐Inflammation and Photoenhanced Antitumor Therapy of Colon Diseases
Authors: Deng Jingwen , Xian Dongyi , Cai Xiaopeng , Liao Shaoxia , Lei Siqin , Han Fengyan , An Yandong , He Qing , Quan Guilan , Wu Chuanbin , Peng Tingting , Lu Chao , Zhang Honghe 
Published: April 2023

AbstractThe development of colitis‐associated colorectal cancer is known to be associated with the inflammation‐dysplasia‐carcinoma pathway, and thus, chronic inflammation represents an inducer and promoter of cancer. To inhibit the evolution from colitis to colorectal cancer and provide an efficient anticancer therapy, a surface‐engineered vanadium carbide MXene nanoenzyme (MXenzyme) is developed with both amino functionalization and gallium doping (Ga/V2C‐NH2). Benefiting from multiple enzyme‐mimicking activities, MXenzymes have shown great potential to decrease excessive reactive oxygen species and inhibit the levels of proinflammatory cytokines, resulting in good anti‐inflammatory effects on dextran sulfate sodium‐induced acute colitis. Moreover, the gallium‐doped MXene with an amino‐functionalized surface can mediate improved MXene‐tumor interactions and inhibitory effects on cell proliferation, achieving precise and efficient chemo‐photothermal therapy. Elemental doping into MXene is also highlighted as a feasible strategy to achieve the loading and controlled release of gallium. As a result, complete tumor ablation without further recurrence is observed for the colon cancer‐bearing mice that receive Ga/V2C‐NH2 and near infrared irradiation, while the MXenzyme system displays excellent biocompatibility at both the cellular and animal levels. These findings not only enrich the research of MXene, but also illustrate its efficient therapeutic promise in anti‐inflammation and photoenhanced antitumor therapy of colon diseases.
Membrane Rigidity‐Tunable Fusogenic Nanosensor for High Throughput Detection of Fusion‐Competent Influenza A Virus
Authors: Park Chaewon , Kim Eunjung , Park Geunseon , Kim Byoung Choul , Vellampatti Srivithya , Lim Jong‐Woo , Lee Sojeong , Chung Soohyun , Jun Sung‐Hoon , Lee Sangyoon , Ali Sajid , Yeom Minjoo , Song Daesub , Haam Seungjoo 
Published: April 2023

AbstractThe emergence of fatal viruses that pose continuous threats to global health has fueled the intense effort to develop direct, accurate, and high‐throughput virus detection platforms. Current diagnostic methods, including qPCR and rapid antigen tests, indicate how much of the virus is present, whether small fragments or whole viruses. However, these methods do not indicate the probability of the virus to be active, capable of interacting with host cells and initiating the infection cycle. Herein, a sialic acid‐presenting fusogenic liposome (sLipo–Chol) nanosensor with purposefully modulated membrane rigidity to rapidly detect the fusion‐competent influenza A virus (IAV) is developed. This nanosensor possesses virus‐specific features, including hemagglutinin (HA) binding and HA‐mediated membrane fusion. It is explored how the fusogenic capability of sLipo–Chol with different membrane rigidities impacts their sensing performance by integrating Förster resonance energy transfer (FRET) pairs into the bilayers. The addition of an intact virus led to instant FRET signal changes, thus enabling the direct detection of diverse IAV subtypes—even in avian fecal samples—within an hour at room temperature. Therefore, the sensing approach, with an understanding of the cellular pathogenesis of influenza viruses, will aid in developing bioinspired nanomaterials for evolution into nanosystems to detect infection‐competent viruses.
Biphasic Transition Metal Nitride Electrode Promotes Nucleophile Oxidation Reaction for Practicable Hybrid Water Electrocatalysis
Authors: Zhu Yin , Qian Qizhu , Chen Yanxu , He Xiaoyue , Shi Xingwei , Wang Wentao , Li Ziyun , Feng Yafei , Zhang Genqiang , Cheng Fangyi 
Published: April 2023

AbstractGlycerol electrooxidation (GOR), as a typical nucleophile oxidation reaction, is deemed as a promising alternative anodic route to assist cathodic hydrogen evolution reaction. However, the investigations of high‐performance catalysts and industrial‐scale application of GOR remain a grand challenge. Herein, biphasic Ni3N/Co3N heterostructure nanowires (denoted as Ni3N/Co3N‐NWs) are proposed as an efficient bifunctional catalyst, which realizes a high Faradaic efficiency of 94.6% toward formate production. Importantly, the flow electrolyzer achieves an industry‐level current density of 1 A cm−2 at 2.01 V with impressive stability for steady running over 200 h, realizing lower electricity expense of 4.82 kWh m−3H2 and energy saving efficiency of 9.7%, as well as outstanding co‐production rates of 11 and 21.4 mmol cm−2 h−1 toward formate and H2, respectively. Theoretical calculations reveal that the efficient electron transfer on Ni3N/Co3N heterointerfaces simultaneously optimizes nucleophile reaction tendency and glycerol dehydrogenation kinetics, thus contributing to excellent GOR performance.
Computational Simulation for Breakdown and Energy Storage Performances with Optimization in Polymer Dielectrics
Authors: Yue Dong , Yin Jing‐Hua , Zhang Wen‐Chao , Cheng Xiao‐Xing , Zhang Mao‐Hua , Wang Jian‐Jun , Feng Yu 
Published: April 2023

AbstractThe breakthrough of energy storage technology will enable energy distribution and adaptation across space‐time, which is revolutionary for the generation of energy. Optimizing the energy storage performance of polymer dielectrics remains challenging via the physical process of electrical breakdown in solid dielectrics is hard to be intuitively obtained. In this review article, the application of computational simulation technologies is summarized in energy‐storage polymer dielectrics and the effect of control variables and design structures on the material properties with an emphasis on dielectric breakdown and energy storage performance are highlighted. The prediction and evaluation of material properties by combining various data analysis methods are reviewed. Finally, the outlook and challenges are discussed based on their current developments. This article covers not only an overview of the state‐of‐the‐art advances of breakdown modeling in energy‐storage polymer dielectrics but also the prospects that provide a new knob to synthesize high energy‐storage polymer dielectrics via computational simulation and a new research paradigm.