bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stigma in people living with bipolar disorder and their families: a systematic review
Authors: Latifian Maryam , Abdi Kianoush , Raheb Ghoncheh , Islam Sheikh Mohammed Shariful , Alikhani Rosa 
Published: February 2023

AbstractBackgroundStigma affects different life aspects in people living with bipolar disorder and their families. This study aimed to examining the experience of stigma and evaluating predictors, consequences and strategies to combat stigma in people with bipolar disorder and their families.MethodsWe conducted a systematic review according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) in 2022. We extensively reviewed six online databases (PubMed, Scopus, Medline, EMBASE, Web of Science and Google Scholar). Articles published in the English language about stigma in people living with bipolar disorders and their families were included.ResultsA total of 42,763 articles were retrieved, of which 40 articles from 14 countries were included in this study (n = 7417 participants). Of the 40 articles, 29 adopted quantitative methods (72.5%), two used mixed-methods (5%), eight used qualitative (20%) methods, and one was a case series (2.5%). The results of the studies were categorized into four themes: 1. Stigma experienced by people living with bipolar disorders and their families, 2. Predictors of stigma in people living with bipolar disorders and their families, 3. Consequences of stigma in people living with bipolar disorders and their families, 4. Effective interventions and strategies to reduce stigma in people living with bipolar disorders and their families.ConclusionThe results of this study might be useful to design psychiatric cognitive interventions to reduce stigma in people living with bipolar disorders and their families and designing community-based interventions to normalize bipolar disorder at the community level.
Spanish adaptation of the Burden Assessment Scale in family caregivers of people diagnosed with borderline personality disorder
Authors: García-Alandete Joaquín , Fernández-Felipe Isabel , Fonseca-Baeza Sara , Fernández Irene , Pérez Sandra , Marco José H. , Guillén Verónica 
Published: February 2023

Abstract
Background
Caregiving is a strong source of stress and leads the family caregiver to experience the burden of being responsible for the care of a severely mentally ill family member. The Burden Assessment Scale (BAS) assesses burden in family caregivers. This study aimed to analyze the psychometric properties of the BAS in a sample of family caregivers of people diagnosed with Borderline Personality Disorder (BPD).

Methods
Participants were 233 Spanish family caregivers (157 women and 76 men aged between 16–76 years old, M = 54.44, SD = 10.09) of people diagnosed with BPD. The BAS, the Multicultural Quality of Life Index, and the Depression Anxiety Stress Scale-21 were used.

Results
An exploratory analysis resulted in a three-factor 16-item model (Disrupted Activities; Personal and Social Dysfunction; Worry, Guilt, and Being Overwhelmed) with an excellent fit (χ2(101) = 56.873, p = 1.000, CFI = 1.000, TLI = 1.000, RMSEA = .000, SRMR = .060), good internal consistency (ω = .93), a negative correlation with quality of life, and a positive correlation with anxiety, depression, and stress.

Conclusion
The model obtained for the BAS is a valid, reliable, and useful tool for assessing burden in family caregivers of relatives diagnosed with BPD.
Advances and key considerations of liquid chromatography–mass spectrometry for porcine authentication in halal analysis
Authors: Dewi Kifayati Rosiyanti , Ismayati Maya , Solihat Nissa Nurfajrin , Yuliana Nancy Dewi , Kusnandar Feri , Riantana Handy , Heryani Heryani , Halim Abdul , Acter Thamina , Uddin Nizam , Kim Sunghwan 
Published: February 2023

AbstractThe halal food industries are rapidly expanding to fulfill global halal demands. Non-halal substances such as porcine proteins are often added intentionally or unintentionally to products. The development of highly selective and sensitive analytical tools is necessary, and liquid chromatography–mass spectrometry is a powerful tool that can cope with the challenge. The LC–MS method has great potential for halal authentication, because it has high sensitivity and low detection limit and detects several species markers and different tissue origins at once within one species. This article provides an understanding of recent advances in the application of LC–MS for the improvement of porcine authentication. Sample preparation, marker selection, separation and mass spectrometry conditions, quantitative assessment, and data processing for protein identification were all covered in detail to choose the most suitable method for the analytical needs.
Fatal and non-fatal firearm-related injuries in Canada, 2016–2020: a population-based study using three administrative databases
Authors: Toigo Stephanie , Pollock Nathaniel J. , Liu Li , Contreras Gisèle , McFaull Steven R. , Thompson Wendy 
Published: February 2023

AbstractBackgroundFirearms are a substantial cause of injury-related morbidity and mortality in Canada and globally, though evidence from contexts other than the USA is relatively limited. We examined deaths, hospitalizations and emergency department (ED) visits due to firearm-related injuries in Canada to identify population groups at increased risk of fatal and non-fatal outcomes.MethodsWe conducted a population-based study using three national administrative databases on deaths, hospitalizations, and ED visits. ICD-10 codes were used to identify firearm-related injuries from January 1, 2016, through December 31, 2020. Fatal and non-fatal firearm injuries were classified as suicide/self-harm, homicide/assault, unintentional, undetermined or legal intervention injuries. We analyzed the data with counts, rates and proportions, stratified by sex, age group, province/territory, and year.ResultsOver the 5-year period, we identified 4005 deaths, 3169 hospitalizations, and 2847 ED visits related to firearm injuries in various jurisdictions in Canada. Males comprised the majority of fatal and non-fatal injury cases. The highest rates of fatal and non-fatal firearm injuries were among 20- to 34-year-olds. The leading cause of fatal firearm injuries was self-harm (72.3%). For non-fatal firearm hospitalizations and ED visits, assault (48.8%) and unintentional injuries (62.8%) were the leading causes of injury. Rates varied by province and territory.ConclusionsOur results showed that males comprised the majority of fatal and non-fatal firearm injuries in Canada. The rates of both fatal and non-fatal firearm injuries were highest among the 20- to 34-year-old age group. This comprehensive overview of the epidemiology of firearm injuries in Canada provides baseline data for ongoing surveillance and policy evaluation related to public health interventions.
Imported diseases in travellers presenting to the emergency department after a stay in a malaria-endemic country: a retrospective observational study
Authors: Desmet Sofie , Henckaerts Liesbet , Ombelet Sien , Damanet Benjamin , Vanbrabant Peter 
Published: February 2023

Abstract
Background
We aimed to investigate the aetiology and outcomes of illnesses in patients presenting to an emergency department after travelling to a malaria-endemic country, in order to raise awareness of both tropical and cosmopolitan diseases.

Methods
A retrospective chart review was performed for all patients who underwent blood smear testing for malaria at the Emergency Department of the University Hospitals Leuven from 2017 to 2020. Patient characteristics, results of laboratory and radiological examinations, diagnoses, disease course and outcome were collected and analysed.

Results
A total of 253 patients were included in the study. The majority of ill travellers returned from Sub-Saharan Africa (68.4%) and Southeast Asia (19.4%). Their diagnoses fell into three major syndrome categories: systemic febrile illness (30.8%), inflammatory syndrome of unknown origin (23.3%) and acute diarrhoea (18.2%). Malaria (15.8%) was the most common specific diagnosis in patients with systemic febrile illness, followed by influenza (5.1%), rickettsiosis (3.2%), dengue (1.6%), enteric fever (0.8%), chikungunya (0.8%) and leptospirosis (0.8%). The presence of hyperbilirubinemia and thrombocytopenia increased the probability of malaria, with a likelihood ratio of 4.01 and 6.03, respectively. Seven patients (2.8%) were treated in the intensive care unit, and none died.

Conclusion
Systemic febrile illness, inflammatory syndrome of unknown origin and acute diarrhoea were the three major syndromic categories in returning travellers presenting to our emergency department after a stay in a malaria-endemic country. Malaria was the most common specific diagnosis in patients with systemic febrile illness. None of the patients died.
Interindividual Variability in Mental Fatigue-Related Impairments in Endurance Performance: A Systematic Review and Multiple Meta-regression
Authors: Habay Jelle , Uylenbroeck Robin , Van Droogenbroeck Ruben , De Wachter Jonas , Proost Matthias , Tassignon Bruno , De Pauw Kevin , Meeusen Romain , Pattyn Nathalie , Van Cutsem Jeroen , Roelands Bart 
Published: February 2023

Abstract
Background
The negative effect of mental fatigue (MF) on physical performance has recently been questioned. One reason behind this could lie in the interindividual differences in MF-susceptibility and the individual features influencing them. However, the range of individual differences in mental fatigue-susceptibility is not known, and there is no clear consensus on which individual features could be responsible for these differences.

Objective
To give an overview of interindividual differences in the effects of MF on whole-body endurance performance, and individual features influencing this effect.

Methods
The review was registered on the PROSPERO database (CRD42022293242). PubMed, Web of Science, SPORTDiscus and PsycINFO were searched until the 16th of June 2022 for studies detailing the effect of MF on dynamic maximal whole-body endurance performance. Studies needed to include healthy participants, describe at least one individual feature in participant characteristics, and apply at least one manipulation check. The Cochrane crossover risk of bias tool was used to assess risk of bias. The meta-analysis and regression were conducted in R.

Results
Twenty-eight studies were included, with 23 added to the meta-analysis. Overall risk of bias of the included studies was high, with only three presenting an unclear or low rating. The meta-analysis shows the effect of MF on endurance performance was on average slightly negative (g = − 0.32, [95% CI − 0.46; − 0.18], p < 0.001). The multiple meta-regression showed no significant influences of the included features (i.e. age, sex, body mass index and physical fitness level) on MF-susceptibility.

Conclusions
The present review confirmed the negative impact of MF on endurance performance. However, no individual features influencing MF-susceptibility were identified. This can partially be explained by the multiple methodological limitations such as underreporting of participant characteristics, lack of standardization across studies, and the restricted inclusion of potentially relevant variables. Future research should include a rigorous description of multiple different individual features (e.g., performance level, diet, etc.) to further elucidate MF mechanisms.
Humoral response after BNT162b2 vaccine in Japanese hemodialysis patients
Authors: Miyazaki Ryoichi , Miyagi Kyoko , Yoshida Misaki , Suzuki Yasunori 
Published: February 2023

Abstract
Background
Hemodialysis patients are more likely to be severely affected if infected by COVID-19. Contributing factors include chronic kidney disease, old age, hypertension, type 2 diabetes, heart disease, and cerebrovascular disease. Therefore, action against COVID-19 for hemodialysis patients is an urgent issue. Vaccines are effective in preventing COVID 19 infection. In hemodialysis patients, however, responses to hepatitis B and influenza vaccines are reportedly weak. The BNT162b2 vaccine has shown an efficacy rate of about 95% in the general population, but as far as we know there are only several reports of efficacy data in hemodialysis patients in Japan.

Methods
We assessed serum anti-SARS-CoV-2 IgG antibody (Abbott SARS-CoV-2 IgG II Quan) in 185 hemodialysis patients and 109 health care workers. The exclusion criterion was positivity for SARS-CoV-2 IgG antibody before vaccination. Adverse reactions to BNT162b2 vaccine were evaluated through interviews.

Results
Following vaccination, 97.6% of the hemodialysis group and 100% of the control group were positive for the anti-spike antibody. The median level of anti-spike antibody was 2,728.7 AU/mL (IQR, 1,024.2–7,688.2 AU/mL) in the hemodialysis group and 10,500 AU/ml (IQR, 9,346.1–2,4500 AU/mL) in the health care workers group. The factors involved in the low response to the BNT152b2 vaccine included old age, low BMI, low Cr index, low nPCR, low GNRI, low lymphocyte count, steroid administration, and complications related to blood disorders.

Conclusions
Humoral responses to BNT162b2 vaccine in hemodialysis patients are weaker than in a healthy control sample. Booster vaccination is necessary for hemodialysis patients, especially those showing a weak or non-response to the two-dose BNT162b2 vaccine.
Trial registration UMIN, UMIN000047032. Registered 28 February 2022, https://center6.umin.ac.jp/cgi-bin/ctr/ctr_reg_rec.cgi.
Quantitative Iodine-123 single-photon emission computed tomography/computed tomography for Iodine-131 therapy of an autonomously functioning thyroid nodule
Authors: Lee Won Woo , Song Yoo Sung , So Young 
Published: February 2023

Abstract
Purpose
Autonomously functioning thyroid nodules (AFTNs) are treated with iodine-131 (I-131) therapy, which increases the risk of permanent hypothyroidism; however, the risk can be reduced by separately estimating the accumulated activity for the AFTN and extranodular thyroid tissue (ETT).

Methods
A quantitative I-123 single-photon emission computed tomography (SPECT)/CT (5 mCi) was performed in one patient with unilateral AFTN and T3 thyrotoxicosis. The I-123 concentrations measured at 24 h were 12.26 µCi/mL and 0.11 µCi/mL in the AFTN and contralateral ETT, respectively. Thus, the I-131 concentrations and radioactive iodine uptake expected at 24 h by 5 mCi of I-131 were 38.59 µCi/mL and 0.31 for the AFTN and 0.34 µCi/mL and 0.007 for the contralateral ETT. The weight was calculated as CT-measured volume multiplied by 1.03.

Results
In the AFTN patient with thyrotoxicosis, we administered 30 mCi of I-131, which would maximize the 24-h I-131 concentration in the AFTN (226.86 µCi/g) and maintain a tolerable concentration in the ETT (1.97 µCi/g). The percentage of I-131 uptake at 48 h post I-131 administration was 62.6%. The patient achieved a euthyroid state at 14 weeks and maintained the state until 2 years post I-131 administration with an AFTN volume reduction of 61.38%.

Conclusion
The pre-therapeutic planning of quantitative I-123 SPECT/CT may enable a therapeutic window for I-131 therapy, which directs optimal I-131 activity to effectively treat AFTN while preserving the normal thyroid tissue.
Beneficial effect of honeybee-specific lactic acid bacteria on health and activity of Apis mellifera L. colonies
Authors: Elenany Yasser Essam , Hassan Ashwak Abdel-Moneim 
Published: February 2023

Abstract
Background
Objective of this work was to investigate the impact of isolated honeybee-specific-lactic acid bacteria (Hbs-LAB) that isolated from worker's bee intestinal tracts on bee health as well as bee colony activity parameters. Independent assays were conducted from February to July, 2021 in apiary yard of Faculty of Agriculture, Cairo University, Giza, Egypt. Colonies were allocated to 2 experimental groups each of 10 colonies, Control colonies were fed with sugar syrup, while the treated colonies were fed with sugar syrup supplemented with mixture of Hbs-LAB (Lactobacillus brevis-HBE2, Lactobacillus casei-HBE5, and Enterococcus Faecalis-HBE1, 3 gm bacterial belts (1:1:1) mixed with 1.5 L of sugar syrup.

Results
The treated colonies recorded high significant differences in all activity parameters (worker's and drone's brood areas, amount of honey and pollen stored, and no. of combs covered with bees) than controlled colonies. In addition, total protein in workers hemolymph samples of treated colonies showed more number of protein bands and the hemolymph molecular low weight protein bands was 99.24 ± 0.3, whereas the high weight protein bands reached 183.87 ± 0.3 KDa, while for untreated colonies the hemolymph molecular low weight protein bands (KDa) were 70.99 ± 0.3 and the high weight protein bands reached 171.57 ± 0.2 KDa.

Conclusions
The Hbs-LAB proved to be a natural protocol that will positively impact the beekeepers’ economy by providing a higher yield of bee products as well as improve the protein values in worker’s hemolymph which is a superior tool for colonies resistance against several diseases that attack their hives.
Spectrophotometric, chromatographic and bioanalysis of selected recently approved drugs from 2015–2020 to treat cardiovascular diseases: an analytical review
Authors: Gharge Shankar , Koli Rahul , Gudasi Sachin , Hiremath Sushmita I. 
Published: February 2023

AbstractBackgroundHeart Study has been operating for more than 40 years, and throughout that time it has found a number of risk variables that interact negatively to have an overall negative effect on cardiovascular disease (CVD) with an estimated 17.9 million deaths per year, CVD is the world's leading cause of death.Main bodyIn the current study, we present spectrophotometric, chromatographic analysis and bioanalysis methods for qualitative and quantitative evaluation of 15 drugs, including small and large molecules, that the U.S. FDA approved between 2015 and June 2020 to treat CVD’s and in the current review work, they were presented.Short conclusionThe review's conclusion is that spectroscopic, chromatographic and bioanalysis methods play important role in quality control and standardization of recently approved drugs from 2015 to 2020 for treating CVD’s in its bulk, pharmaceutical dosage form, synthetic mixture or human/rat plasma.
Fuel treatment effectiveness at the landscape scale: a systematic review of simulation studies comparing treatment scenarios in North America
Authors: Ott Jeffrey E. , Kilkenny Francis F. , Jain Theresa B. 
Published: February 2023

AbstractBackgroundThe risk of destructive wildfire on fire-prone landscapes with excessive fuel buildup has prompted the use of fuel reduction treatments to protect valued resources from wildfire damage. The question of how to maximize the effectiveness of fuel reduction treatments at landscape scales is important because treating an entire landscape may be undesirable or unfeasible. We reviewed 86 simulation studies that examined landscape-scale fuel reduction treatment effectiveness for landscapes of the USA or Canada. Each of these studies tested effects of fuel reduction treatments on wildfire through comparisons of landscape scenarios differing by treatment design or other attributes. Results from these studies were summarized to assess what they reveal about factors determining fuel treatment effectiveness at landscape scales.ResultsQualifying studies focused primarily but not exclusively on forested landscapes of the western USA and ranged in size from 200 to 3,400,000 ha. Most studies showed that scenarios with fuel reduction treatments had lower levels of wildfire compared to untreated scenarios. Damaging wildfire types decreased while beneficial wildfire increased as a result of treatments in most cases where these were differentiated. Wildfire outcomes were influenced by five dimensions of treatment design (extent, placement, size, prescription, and timing) and other factors beyond the treatments (weather, climate, fire/fuel attributes, and other management inputs). Studies testing factorial combinations showed that the relative importance of these factors varied across landscapes and contexts.ConclusionsSimulation studies have highlighted general principles of effective fuel treatment design at landscape scales, including the desirability of treating extensive areas with appropriate prescriptions at sufficient frequency to reduce wildfire impacts even under extreme conditions that may be more prevalent in the future. More specific, context-dependent strategies have also been provided, such as a variety of placement schemes prioritizing the protection of different resources. Optimization algorithms were shown to be helpful for determining treatment placement and timing to achieve desired objectives under given constraints. Additional work is needed to expand the geographical scope of these studies, further examine the importance and interactions of driving factors, and assess longer-term effects of fuel reduction treatments under projected climate change.
Frequency and risk factors of musculoskeletal disorders among kitchen workers
Authors: Abdelsalam Abeer , Wassif Ghada O. , Eldin Waleed Salah , Abdel-Hamid Mona A. , Damaty Samia I. 
Published: February 2023

Abstract
Background
Kitchen work is associated with exposure to heavy workload which has been linked to work-related musculoskeletal disorders (WRMSDs) and many other occupational hazards. This study aimed to measure the frequency of WRMSDs related to working in kitchens of two major Egyptian students’ hostels, to determine the associated risk factors, and determine the distribution of musculoskeletal problems in various joints in different job categories.

Methods
A cross-sectional analytical study was carried out among 128 kitchen workers of two major students’ hostels in Cairo, Egypt. A structured interview questionnaire was used to collect information on personal and occupational data and the prevalence of musculoskeletal pain in the past 12 months based on the valid Nordic musculoskeletal disorders questionnaire (NMQ).

Results
The study revealed that the majority of kitchen workers (90.6%) at the students’ hostel reported WRMSDs within the past 12 months. The lower back (64.8%), knee (46.9%), foot (46.1%), neck (29.7%), and shoulders (23.4%) were the most affected sites. Age, educational status, job category, job duration, and body mass index (BMI) were significantly associated with WRMSDs among kitchen workers.

Conclusion
kitchen workers are at a high risk of musculoskeletal disorders (MSDs) due to the poor work environment, the massive workload, and great time pressure to perform their duties. Interventions such as hiring more workers of younger age, providing rest breaks, and health education about occupational hazards to reduce the risk of musculoskeletal problems should be reinforced.