bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychobehavioural profile in narcolepsy type 1 with and without REM sleep behaviour disorder
Authors: Mombelli Samantha , Ricordeau François , Gillard Léa , Lecca Rosa , Vidal Tiphaine , Pereira Bruno , Beudin Patricia , Vitello Nicolas , Bastuji Helene , Peter‐Derex Laure , Fantini Maria Livia 
Published: May 2023

SummaryREM sleep behaviour disorder (RBD) is common in narcolepsy type 1 (NT1). Abnormalities in the reward system have been observed in NT1, possibly related to impaired orexin projections towards the mesolimbic reward system, but also in RBD when associated with Parkinson's disease. Our study aimed to explore the psychobehavioural profile of NT1 patients with and without RBD compared with healthy controls (HC). Forty patients with NT1 were compared with 20 sex‐ and age‐matched HC. All patients with NT1 underwent a video‐polysomnography including a measure of REM sleep without atonia (RSWA). The following neuropsychobehavioural variables were assessed: apathy, impulsivity, depression, cognition, subjective and objective attention, sensation‐seeking, and behavioural addictions. The patient population included 22 patients with NT1‐RBD and 18 patients with NT1‐noRBD. Compared with the healthy controls, patients with NT1 had higher scores of apathy, impulsivity, and depression; a lower score on global cognition, and poorer self‐perceived attention. No differences were found between patients with NT1 with and without RBD in all neuropsychological variables, except for impaired objective attention in patients with NT1‐RBD. In patients with NT1, a positive correlation was observed between RSWA and both apathy and impulsivity subscale. Moreover, in patients with NT1‐RBD, RSWA was positively correlated with depression. Patients with NT1 showed higher depression, apathy, and impulsivity compared with controls. These measures correlate with the severity of RSWA, suggesting a transdiagnostic association between RBD and abnormalities of the reward system at least for patients with NT1.
Cephalic and saphenous venous blood collected by continuous heating of the paws compared with arterial blood for measurement of blood gas values in well‐perfused dogs
Authors: Shiroshita Yukihito , Tanaka Ryou , Shimizu Miki , Yamane Yoshihisa 
Published: May 2023

AbstractBackground“Arterialization” of the dorsal hand vein is well‐established in human medicine, but not in veterinary medicine.ObjectivesTo compare cephalic and saphenous venous blood collected by continuously heating the paws to 37°C (“arterialization”), with arterial blood (AB) for measurement of blood gas variables in well‐perfused dogs.AnimalsEight healthy dogs.MethodsExperimental study. Fore and hind paws were continuously heated to 37°C to “arterialize” cephalic and saphenous venous blood. AB and “arterialized” cephalic and saphenous venous blood (ACV and ASV, respectively) were simultaneously collected from lightly anesthetized dogs with induced metabolic and respiratory acid‐base disorders. The pH, partial pressures of carbon dioxide (PCO2) and oxygen (PO2), bicarbonate concentration [HCO3−], and base excess (BE) were measured once in each state. Systolic blood pressure was maintained above 100 mm Hg. The AB, ACV, and ASV values were compared.ResultsThe pH, [HCO3−], and BE values had no significant difference and good agreement, the PCO2values had a strong correlation (correlation coefficient of .91‐1.00), and the PO2values had a significant difference (P < .01) and poor agreement between AB and ACV, and between AB and ASV. The PCO2values of ASV overestimated those of AB by ~3.0 mm Hg, which was considered within clinically allowable limits, while those of ACV were not within clinically allowable limits.Conclusions and Clinical ImportanceUnder experimental conditions, the ASV samples were more identical to the AB samples than the ACV samples for pH, PCO2, [HCO3−], and BE values in well‐perfused dogs. The saphenous vein is suitable for “arterialization.”
Therapeutic response and prognostic factors of 14 dogs undergoing transcatheter arterial embolization for hepatocellular masses: A retrospective study
Authors: Kawamura Yuta , Itou Hiroki , Kida Akitomo , Sunakawa Hiroki , Suzuki Moe , Kawamura Kenji 
Published: May 2023

AbstractBackgroundInformation regarding the therapeutic effect and outcome of transcatheter arterial embolization (TAE) for hepatic masses is limited in veterinary medicine.Hypothesis/ObjectivesTo analyze the therapeutic response, outcome (overall survival), and their predictors in dogs that underwent TAE for primary hepatocellular masses. We hypothesized that larger pre‐TAE tumors would be associated with worse outcomes.AnimalsFourteen client‐owned dogs.MethodsRetrospective study. Medical records between 1 September 2016 and 30 April 2022 were reviewed to identify dogs treated with TAE for hepatic masses diagnosed as hepatocellular origin by cytological or histopathological examination. Computed tomography images were compared before and after TAE. The univariate Cox proportional hazards test was performed to assess the associations between variables and survival. Univariate linear regression analysis was performed to assess the associations between variables and the tumor reduction percentage: ([post‐TAE volume − pre‐TAE volume]/pre‐TAE volume) × 100.ResultsThe median survival time was 419 days (95% confidence interval, 82‐474). History of intra‐abdominal hemorrhage (P = .03) and pre‐TAE tumor volume/body weight (P = .009) were significantly associated with overall survival. The mean reduction percentage was −51% ± 40%. Pre‐TAE tumor volume/body weight ratio (cm3/kg; P = .02, correlation coefficient = 0.704) was significantly correlated with the volume reduction percentage.ConclusionsHistory of intra‐abdominal hemorrhage and large pre‐TAE tumor volume/body weight ratio could be predictive factors for adverse outcomes after TAE. Pre‐TAE tumor volume/body weight ratio could be a predictive factor for therapeutic effect.
Sumptuary administration: How contested market actors shape the trajectory of policy when regulated under fragmented governance
Authors: Kinney Alexander B. 
Published: May 2023

AbstractIn contemporary society, sumptuary laws regulate contested markets by delegating enforcement responsibilities to the private sector. This can decouple the intention behind policies from the practices to implement them. When state interests do not align concerning the legality of a market, can policy and practice recouple, and if so, how? This article reports on a case study of commercial cannabis in the United States to answer this question. Interviews with 56 cannabis industry stakeholders in California, Arizona, and Texas reveal that policy and practice recoupled through a patterned process that I call sumptuary administration. In each state, regulators drew on a unique set of schemas, or “framework of accountability,” that prioritized a subset of cannabis market participants during the policy‐making process. This resulted in missing or ambiguous sumptuary laws. To address business challenges that were tethered to this regulatory environment, cannabis businesses drew on similar schemas to identify appropriate practices. I show how grounding practices in these frameworks legitimized the preferences of the cannabis industry in the eyes of state authorities and influenced specific program policy revisions. Sumptuary administration represents a novel mechanism for understanding the social construction of legality in markets that are regulated under fragmented governance.
Protective role of cGAS in NASH is related to the maintenance of intestinal homeostasis
Authors: de Carvalho Ribeiro Marcelle , Cho Yeonhee , Mehta Jeeval , Wang Xiaojing , Babuta Mrigya , Copeland Christopher , Hussein Hosni , Catalano Donna , Wang Yanbo , Szabo Gyongyi 
Published: May 2023

AbstractBackground & AimsVarious intracellular pathways regulate inflammation in NASH. Cyclic GMP‐AMP synthase (cGAS) is a DNA sensor that activates STING and plays a role in inflammatory diseases. Here, we explored the role of cGAS in hepatic damage, steatosis, inflammation, and liver fibrosis in mouse models of NASH.MethodscGAS deficient (cGAS‐KO) and STING deficient (STING‐KO) mice received high fat‐high cholesterol‐high sugar diet (HF‐HC‐HSD) or relevant control diets. Livers were evaluated after 16 or 30 weeks.ResultsHF‐HC‐HSD diet, both at 16 and 30 weeks, resulted in increased cGAS protein expression as well as in increased ALT, IL‐1β, TNF‐α and MCP‐1 in wild‐type (WT) mice compared to controls. Surprisingly, liver injury, triglyceride accumulation, and inflammasome activation were greater in HF‐HC‐HSD cGAS‐KO compared to WT mice at 16 and to a lesser extent at 30 weeks. STING, a downstream target of cGAS was significantly increased in WT mice after HF‐HC‐HSD. In STING‐KO mice after HF‐HC‐HSD feeding, we found increased ALT and attenuated MCP1 and IL‐1β expression compared to WT mice. Markers of liver fibrosis were increased in cGAS‐ and STING‐KO mice compared to WT on HF‐HC‐HSD. We discovered that cGAS‐KO mice had a significant increase in circulating endotoxin levels on HF‐HC‐HSD that correlated with changes in intestinal morphology which was exacerbated by HF‐HC‐HSD compared to WT mice.ConclusionOur findings indicate that cGAS or STING deficiency exacerbate liver damage, steatosis, and inflammation in HF‐HC‐HSD diet‐induced NASH, which might be linked to the disruption of the gut barrier.
Capturing species‐wide diversity of the gut microbiota and its relationship with genomic variation in the critically endangered kākāpō
Authors: West Annie G. , Digby Andrew , Santure Anna W. , Guhlin Joseph G. , Dearden Peter , Kākāpō Recovery Team  , Taylor Michael W. , Urban Lara 
Published: May 2023

AbstractGut microbiota play an essential role in host health with important implications for conservation management of threatened wildlife. While factors such as diet, medication and habitat are known to shape the microbiota, our understanding of the entirety of factors, including the complex role of host genomic background, remains incomplete. Our research on the interaction between the host genome and gut microbiota of the critically endangered kākāpō (Strigops habroptilus), a flightless parrot endemic to Aotearoa New Zealand, represents, to our knowledge, one of the most comprehensive studies of the gastrointestinal bacterial diversity and its relationship with host genomic diversity for virtually an entire threatened species. We conducted a 16S rRNA gene‐based analysis of faecal samples representing the gut microbiota for 84% of kākāpō. This survey was leveraged with exceptional metadata to tease apart the impact of host genomic diversity and factors including sex, age, diet, antibiotics, disease, habitat and sampling date on the kākāpō gut microbiota. We find evidence of a highly polygenic genomic architecture of the gut microbiota and identify putative associations between bacterial diversity and functional pathways related to intestinal homeostasis, inflammation, immunity and metabolism. This improved understanding of the kākāpō gut microbiota—and its relationship with host genomics—can directly benefit kākāpō conservation by providing new insights into the role of the gut microbiome in kākāpō health and disease mitigation. Overall, we anticipate that an integration of microbiome studies in conservation research and management will improve our understanding and realisation of the One Health concept.
Cardiac resynchronization therapy in adults with structural congenital heart disease and chronic heart failure
Authors: Thompson Sophie E. , Hudsmith Lucy E. , Bowater Sarah E. , Clift Paul , Marshall Howard , Leyva. Francisco , Arif Sayqa 
Published: May 2023

AbstractAimsEvidence for CRT in adults with congenital heart disease (ACHD) and chronic heart failure is limited, with recommendations for its use extrapolated from the population with structurally normal hearts. This retrospective observational study investigates the efficacy of CRT in this heterogenous group, discussing factors predicting response to CRT.MethodsTwenty‐seven patients with structural ACHD who underwent CRT insertion or upgrade at a tertiary center in the United Kingdom were retrospectively studied. The primary outcome measure was clinical response to CRT, defined as improvement of NYHA class and/or improvement in systemic ventricular ejection fraction by one category. Secondary outcomes included change in QRS duration and adverse events.ResultsThirty‐seven percent of patients had a systemic right ventricle (sRV). RBBB was the commonest baseline QRS morphology (40.7%) despite this being an unfavorable characteristic for CRT. Overall, positive response to CRT was demonstrated in 18 patients (66.7%). NYHA class improved in 55.5% following CRT (p = .001) and 40.7% showed improvement in systemic ventricular ejection fraction (p = .118). There were no baseline characteristics that predicted response to CRT, and electrocardiographic measures such as QRS shortening post‐CRT was not associated with positive response. Good response rates (60.0%) were demonstrated in those with sRV.ConclusionCRT is efficacious in structural ACHD including in those who do not meet conventional criteria. Extrapolation of recommendations from adults with structurally normal hearts may be inappropriate. Future research should focus on improving patient selection for CRT, for example using techniques to better quantify mechanical dysynchrony and intra‐procedural electrical activation mapping in these complex patients.
Validation of a handheld single‐lead ECG algorithm for atrial fibrillation detection after coronary revascularization
Authors: Skröder Sofia , Wickbom Anders , Björkenheim Anna , Ahlsson Anders , Poci Dritan , Fengsrud Espen 
Published: May 2023

AbstractBackgroundAtrial fibrillation (AF) is a rapidly increasing global public health concern entailing a high risk for ischemic stroke that can largely be avoided with anticoagulation therapy. AF is often underdiagnosed and there is a need for a reliable method of detection in individuals with additional risk factors for stroke such as coronary artery disease. We aimed to validate an automatic rhythm interpretation algorithm in thumb ECG in subjects with recent coronary revascularization.MethodsThumb ECG, a patient‐operated handheld single‐lead ECG recording device with an automatic interpretation algorithm, was performed three times daily for a month after coronary revascularization and 2‐week periods 3, 12, and 24 months post‐procedure. The detection of AF by the automatic algorithm on subject and single‐strip ECG level was compared to manual interpretation.Results48,308 of 30 s thumb ECG recordings from 255 subjects (mean 212 ± 3.5 recordings per subject) were retrieved from a database (AF 47 subjects/655 recordings; non‐AF 208 subjects/47,653 recordings). The algorithm sensitivity at subject level was 100%, specificity 11.2%, positive predictive value (PPV) 20.2%, and negative predictive value (NPV) 100%. At the single‐strip ECG level, sensitivity was 87.6%, specificity 94.0%, PPV 16.8%, and NPV 99.8%. The most common reasons for false positive results were technical disturbance and frequent ectopic beats.ConclusionsThe automatic interpretation algorithm in a handheld thumb ECG device can rule out AF in patients recently undergoing coronary revascularization with high accuracy, but manual confirmation is needed to confirm the diagnose of AF because of high false positive rates.
The nature and normativity of anger types: A response to critics
Authors: Cherry Myisha 
Published: May 2023

AbstractMy commentators have brought a set of claims and questions to bear on my analytical distinctions and normative arguments. Alice MacLachlan is interested in the relationship between Lordean rage and the other, more negative anger types that I describe, as well as the limits of the anger of rage renegades. Lidal Dror wonders if we should have Lordean rage, to what extent my account of resssentiment rage is in fact Lordean, and whether it is enough to only experience Lordean rage. And Nic Bommarito wonders if my other anger types could be good in certain ways and if there are other “Lordean emotions.” So, in my replies, I will address each of these in turn. And I end with a brief note about love and Lordean rage.
The 1949 Atlas of French peat deposits, a starting point for a national inventory of peatlands
Authors: Pinault Lise , Pilloix Malo , Bernard Gregory , Joly Daniel , Gogo Sébastien , Martin Elsa , Gilbert Daniel 
Published: May 2023

AbstractFifty per cent of European peatlands are in a damaged state. While intact peatlands are natural carbon sinks, degraded sites release important amounts of greenhouse gases into the atmosphere, contributing to global warming. Restoration of the hydrological functionality of peatlands has proved to be an efficient tool to avoid these emissions. In France, Tuffnell & Bignon's ministerial report (2019) emphasized the need for peatlands ‘integration into the National Low Carbon Strategy, targeting carbon neutrality by 2050. However, current knowledge regarding French peatlands’ distribution and carbon stocks is insufficient and does not allow decision makers and managers to prioritize areas for restoration. The most complete database to date is the 1949 Atlas, an inventory of exploitable peat deposits that was conducted during WWII for peat exploitation as fuel. Until its digitalization, the latter database was archived and never used in a scientific study. It provides detailed information about peatland surfaces, peat thicknesses and carbon contents at that time. We estimated peat carbon stocks from French peatlands to be 111 Mt C in 1949 for 63,290 ha identified as peaty sites, the equivalent of 3% of the organic carbon contained in the upper 30 centimetres of French soils. 34% of this stock was held in Lower Normandy (37.7 Mt C) and 12% in the Picardy's region (13.0 Mt C), in large lowland peatlands. However, not all peatlands were prospected in the 1949 inventory and the characteristics of the prospected peatlands may have changed with anthropic disturbances of the last decades, such as draining or climate change. These first results highlight the need for a recent inventory of French peatlands and carbon stocks based on local data aggregation. Data from the 1949 Atlas could help constituting this new inventory but should be validated before being used to describe the present.
Evaluation of mechlorethamine, vinblastine, procarbazine, and prednisone for the treatment of resistant multicentric canine lymphoma
Authors: Zimmerman Kelley , Walsh Koranda A. , Ferrari Jonathan T. , Keuler Nicholas S. , Atherton Matthew J. , Lenz Jennifer A. 
Published: May 2023

AbstractMulti‐agent chemotherapy successfully induces remission in most naïve, high‐grade canine lymphoma patients; however, disease recurrence is common. MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) is an effective rescue protocol used to re‐induce remission, but is associated with gastrointestinal toxicity and can be a less desirable option for patients that previously failed vincristine‐containing protocols. Therefore, alternative members of the vinca alkaloid family, such as vinblastine, could be potentially advantageous as substitutes for vincristine to reduce gastrointestinal toxicity and chemoresistance. The objective of this study was to report the clinical outcomes and toxicity of 36 dogs with relapsed or refractory multicentric lymphoma treated with a modified MOPP protocol whereby vincristine was replaced with vinblastine (MVPP). The overall response rate to MVPP was 25% with a median progression free survival of 15 days and a median overall survival of 45 days. MVPP at the prescribed doses resulted in modest and transient clinical benefit, but was well tolerated with no treatment delays or hospitalizations secondary to side effects. Given the minimal toxicity, dose intensification could be considered to improve clinical responses.
Bioenergetic Analysis and Fatigue Assessment During the Fran Workout in Experienced Crossfitters
Authors: Rios Manoel , Zacca Rodrigo , Azevedo Rui , Fonseca Pedro , Pyne David B. , Reis Victor Machado , Moreira-Gonçalves Daniel , Fernandes Ricardo J. 
Published: May 2023

Aim: To quantify the physiological demands and impact of muscle function t of the Fran workout, one of the most popular CrossFit benchmarks. Methods: Twenty experienced CrossFitters—16 male: 29 (6) years old and 4 female: 26 (5) years old— performed 3 rounds (with 30-s rests in between) of 21–21, 15–15, and 9–9 front squats to overhead press plus pull-up repetitions. Oxygen uptake and heart rate were measured at baseline, during the workout, and in the recovery period. Rating of perceived exertion, blood lactate, and glucose concentrations were assessed at rest, during the intervals, and in the recovery period. Muscular fatigue was also monitored at rest and at 5 minutes, 30 minutes, and 24 hours postexercise. Repeated-measures analysis of variance was performed to compare time points. Results: Aerobic (52%–29%) and anaerobic alactic (30%–23%) energy contributions decreased and the anaerobic lactic contribution increased (18%–48%) across the 3 rounds of the Fran workout. Countermovement jump height decreased by 8% (−12 to −3) mean change (95% CI), flight duration by 14% (−19 to −7), maximum velocity by 3% (−5 to −0.1), peak force 4% (−7 to −0.1), and physical performance (plank prone 47% [−54 to −38]) were observed. Conclusions: It appears that the Fran workout is a physically demanding activity that recruits energy from both aerobic and anaerobic systems. This severe-intensity workout evokes substantial postexercise fatigue and corresponding reduction in muscle function.
Principal Perceptions and Applications of Professional Learning Communities: Implications for the Future of Physical Education
Authors: Beddoes Zack E. , Sazama Debra S. 
Published: May 2023

Purpose: To investigate school principals’ perceptions and applications of professional learning communities (PLCs) and how they interpret the roles of physical educators within these structures. Method: This study was conceptualized as an exploratory interview study. Eight elementary and two secondary school principals across four districts participated in semistructured interviews. Each principal had been trained and was currently utilizing the same PLC framework within their respective schools. Result: Data analysis revealed three overarching themes with supportive subthemes: (a) PLCs are Centered on and Structured for Student Learning, (b) The Roles of Physical Educators Differ in Perception and Function, and (c) Successful PLCs are Facilitated by Team Trust and Disrupted by Drift. Discussion: The findings carry implications for principals, physical educators, and physical education teacher education programs. Principals and physical educators have mutually reinforcing responsibilities in creating an equitable space for physical education in the school PLC community.
Feminist Sport Media Studies in SSJ: Mapping Theoretical Frameworks and Geographies of Knowledge Production
Authors: Antunovic Dunja 
Published: May 2023

This conceptual review identifies the contributions of the Sociology of Sport Journal to the subfield of feminist sport media studies. Since the first issue of Sociology of Sport Journal, over 60 articles addressed primarily the media representations research area of feminist sport media studies, using a range of theoretical frameworks that mirrored theoretical shifts in the field. An empirical analysis of geographies of knowledge production indicates that the scholarship in Sociology of Sport Journal in this subfield is primarily based in the United States and focuses on Western contexts. The article concludes with a reflection on the importance of special issues and interdisciplinary collaborations in feminist sport media studies.