bluuebunny/crossref_metadata_2025_split huggingface dataset:
Panel Four: Design Decarbonization, March 30, 2021
Authors: Baxi Kadambari , Goldmark Sandra , Stute Martin , Jurich Joscelyn , Chen Linda , Wang Olivia 
Published: June 2023

AbstractIn this panel discussion, Kadambari Baxi (Architecture), Sandra Goldmark (Theatre), and Martin Stute (Environmental Science) discuss what it means to design for decarbonization from the perspective of their fields of expertise. They explore how they structure their courses to investigate and problematize design and decarbonization issues and how their courses have evolved to address issues of sustainability.
Pathways to Sustainability: Examples from Science Teacher Education
Authors: Rivera Maulucci María S. 
Published: June 2023

AbstractWhy do we need education for sustainability? What is education for sustainability? What are some of the challenges and opportunities a sustainability approach affords? How might a sustainability approach inform science teacher education? This chapter will provide a brief review of the literature on sustainability, environmental education, and education for sustainability, provide a brief history of the concept, and explore how it has been applied in two science teacher education contexts. In addition, by investigating the theoretical and practical challenges of integrating sustainability with the science curriculum in particular, the chapter will provide a basis for understanding the varied approaches taken by other authors in this volume.
When a Titan Arum Blooms During Quarantine
Authors: Gershberg Nicholas 
Published: June 2023

AbstractIt is rare and marvelous when a botanical conservatory acquires a horticultural specimen of the endangered Titan Arum, the euphemism for the corpse flower, Amorphophallus titanum, native to the rainforests of Sumatra, Indonesia. After years of anticipation and optimism, the first blooming of the specimen in Barnard College’s Arthur Ross Greenhouse occurred in April through June 2020, during a lock-down of the campus not only to the public, but to all students and almost all staff. While attending to the rest of the conservatory, Greenhouse Administrator Nick Gershberg pivoted from the facility’s usual in-person neighborly outreach programming to an on-line presence typical of more public facing botanical institutions. Thanks to a popular @barnardgreenhouse Instagram previously created by student workers, an existing audience benefited from live-streaming and time-lapse videos, an interdisciplinary mix of photography, fashion, poetry, music, history, and languages, and a plant naming contest. All aimed to maximize inclusion. Amidst multiple crises in New York City, Minneapolis, and around the nation and globe, the “charismatic mega flora” went far beyond serving as a symbol against deforestation, climate alteration, and overharvesting. It inspired contemplation of the most basic aspect of biodiversity, a non-human organism living its astonishing life.
What Does Cell Biology Have to Do with Saving Pollinators?
Authors: Snow Jonathan 
Published: June 2023

AbstractAs a cell and molecular biologist trained in biomedical sciences, my early research focused on human disease etiology. I was fortunate to be able to realign my research and personal interests in sustainability when I began working on honey bee health as I transitioned to faculty positions at liberal arts colleges. As an Associate Professor of Biology at Barnard College, my teaching focuses on biology at the cell and molecular level, which is strongly associated with problems of human health. A major challenge I have faced centers around connecting the techniques and ways of thinking used in the study of cell biology with the broader environmental issues of honey bee disease and the growing pollinator crisis. In this chapter, I describe how I have worked to incorporate sustainability in a broad sense and justice in a somewhat narrow ecological sense into my lab and my teaching, with a specific focus on my course, Laboratory in Cell Biology. The lab class structure pursued here, which shares many aspects with the course-based undergraduate research experiences (CURE) model, seeks to create an authentic and inclusive environment to increase laboratory science involvement and enthusiasm in students from diverse backgrounds.
Feed-Back About the Collaboration Process from a Group Awareness Tool. Potential Boundary Conditions for Effective Regulation
Authors: Strauß Sebastian , Rummel Nikol 
Published: June 2023

AbstractDuring collaborative learning the learners of a group need to monitor and regulate their interaction processes which requires collecting feed-back about past interaction and using it to adapt the collaboration. In this chapter, we argue that group awareness tools achieve this by visualizing information about the group’s interaction. However, the boundary conditions under which groups benefit from these tools still lack a systemic investigation. Based on prior research on group awareness tools and two small-scale field experiments we propose potential boundary conditions that affect whether groups take up the information from a group awareness tool, process this information, and eventually translate it into actions that adapt the current ways of interaction in the group. The resulting overview points out potential starting points for future research on the design of group awareness tools, on processes that are necessary to leverage group-level feedback, and on effective regulation of collaboration.
On the Alesker-Verbitsky Conjecture on HyperKähler Manifolds
Authors: Dinew Sławomir , Sroka Marcin 
Published: June 2023

AbstractWe solve the quaternionic Monge–Ampère equation on hyperKähler manifolds. In this way we prove the ansatz for the conjecture raised by Alesker and Verbitsky claiming that this equation should be solvable on any hyperKähler with torsion manifold, at least when the canonical bundle is trivial holomorphically. The novelty in our approach is that we do not assume any flatness of the underlying hypercomplex structure which was the case in all the approaches for the higher order a priori estimates so far. The resulting Calabi–Yau type theorem for HKT metrics is discussed.
Superior capsular reconstruction using the long head of the biceps to treat massive rotator cuff tears improves patients shoulder pain, mobility and function
Authors: Gao Qiuming , Qiao Yue , Guan Yonghao , Zhang Yiwei , Xu Tianyang , Duan Zhengwei , Fan Lin , Li Zihua , Li Guodong , Sun Jian 
Published: June 2023

AbstractPurposeArthroscopic superior capsule reconstruction (SCR) with the long head of the biceps (LHBT) was performed to restore structural stability, force couple balance, and shoulder joint function. This study aimed to evaluate the functional outcomes of SCR using the LHBT over at least 24 months of follow‐up.MethodThis retrospective study included 89 patients with massive rotator cuff tears who underwent SCR using the LHBT, met the inclusion criteria and underwent follow up for at least 24 months. The preoperative and postoperative shoulder range of motion (forward flexion, external rotation, and abduction), acromiohumeral interval (AHI), visual analog scale (VAS) score, American Shoulder and Elbow Surgeons (ASES) score and Constant–Murley score were obtained, and the tear size, and Goutallier and Hamada grades were also investigated.ResultsCompared with those measured preoperatively, the range of motion, AHI, and VAS, Constant–Murley, and ASES scores were significantly improved immediately postoperatively (P < 0.001) and at the 6‐month, 12‐month, and final follow‐ups (P < 0.001). At the last follow‐up, the postoperative ASES score and Constant‐Murley score increased from 42.8 ± 7.6 to 87.4 ± 6.1, and 42.3 ± 8.9 to 84.9 ± 10.7, respectively; with improvements of 51 ± 21.7 in forward flexion, 21.0 ± 8.1 in external rotation, and 58.5 ± 22.5 in abduction. The AHI increased 2.1 ± 0.8 mm and the VAS score significantly changed from 6.0 (5.0, 7.0) to 1.0 (0.0, 1.0), at the final follow‐up. Eleven of the 89 patients experienced retears, and one patient needed reoperation.ConclusionIn this study with at least 24‐months of follow‐up, SCR using the LHBT for massive rotator cuff tears could effectively relieve shoulder pain, restore shoulder function and increase shoulder mobility to some extent.Level of evidenceIV.
Characterization of human Fc alpha receptor transgenic mice: comparison of CD89 expression and antibody-dependent tumor killing between mouse strains
Authors: Stip Marjolein C. , Jansen J. H. Marco , Nederend Maaike , Tsioumpekou Maria , Evers Mitchell , Olofsen Patricia A. , Meyer-Wentrup Friederike , Leusen Jeanette H. W. 
Published: June 2023

AbstractSince mice do not express a homologue of the human Fc alpha receptor (FcαRI or CD89), a transgenic mouse model was generated in four different backgrounds (C57BL/6, BALB/c, SCID and NXG) expressing the FcαRI under the endogenous human promoter. In this study, we describe previously unknown characteristics of this model, such as the integration site of the FCAR gene, the CD89 expression pattern in healthy male and female mice and in tumor-bearing mice, expression of myeloid activation markers and FcγRs and IgA/CD89-mediated tumor killing capacity. In all mouse strains, CD89 expression is highest in neutrophils, intermediate on other myeloid cells such as eosinophils and DC subsets and inducible on, among others, monocytes, macrophages and Kupffer cells. CD89 expression levels are highest in BALB/c and SCID, lower in C57BL/6 and lowest in NXG mice. Additionally, CD89 expression on myeloid cells is increased in tumor-bearing mice across all mouse strains. Using Targeted Locus Amplification, we determined that the hCD89 transgene has integrated in chromosome 4. Furthermore, we established that wildtype and hCD89 transgenic mice have a similar composition and phenotype of immune cells. Finally, IgA-mediated killing of tumor cells is most potent with neutrophils from BALB/c and C57BL/6 and less with neutrophils from SCID and NXG mice. However, when effector cells from whole blood are used, SCID and BALB/c are most efficient, since these strains have a much higher number of neutrophils. Overall, hCD89 transgenic mice provide a very powerful model to test the efficacy of IgA immunotherapy against infectious diseases and cancer.
Efficacy and Safety of Gastrointestinal Tumour Site Marking with da Vinci‐Compatible Near‐Infrared Fluorescent Clips: A Case Series
Authors: Takahashi Junji , Yoshida Masashi , Ohdaira Hironori , Nakaseko Yuichi , Nakashima Keigo , Kamada Teppei , Suzuki Norihiko , Sato Takayuki , Suzuki Yutaka 
Published: June 2023

AbstractBackgroundThe conventional near‐infrared fluorescent clip (NIRFC) ZEOCLIP FS® has been used successfully in marking tumour sites during laparoscopic surgeries. However, this clip is difficult to observe with the Firefly imaging system equipped with the da Vinci® surgical system. We have been involved in the modification of ZEOCLIP FS® and development of da Vinci‐compatible NIRFC. This is the first prospective single‐centre case series study verifying the usefulness and safety of the da Vinci‐compatible NIRFC.MethodsTwenty‐eight consecutive patients undergoing da Vinci®‐assisted surgery for gastrointestinal cancer (16 gastric, 4 oesophageal, and 8 rectal cases) between May 2021 and May 2022 were enrolled.ResultsTumour location was identified by the da Vinci‐compatible NIRFCs in 21 of 28 (75%) patients, which involved 12 gastric (75%), 4 oesophageal (100%), and 5 rectal (62%) cancer cases. No adverse events were observed.ConclusionTumour site marking with da Vinci‐compatible NIRFC was feasible in 28 patients enrolled in this study. Further studies are warranted to substantiate the safety and improve the recognition rate.
A novel endovascular robotic-assisted system for endovascular aortic repair: first-in-human evaluation of practicability and safety
Authors: Song Chao , Xia Shibo , Zhang Lei , Wang Kundong , Li Haiyan , Guo Wenying , Zhu Longtu , Lu Qingsheng 
Published: June 2023

Abstract
Objectives
To assess the practicability and safety of a novel endovascular robotic system for performing endovascular aortic repair in human.

Methods
A prospective observational study was conducted in 2021 with 6 months post-operative follow-up. Patients with aortic aneurysms and clinical indications for elective endovascular aortic repair were enrolled in the study. The novel developed robotic system is applicable for the majority of commercial devices and various types of endovascular surgeries. The primary endpoint was technical success without in-hospital major adverse events. Technical success was defined as the ability of the robotic system to complete all procedural steps based on procedural segments.

Results
The first-in-human evaluation of robot-assisted endovascular aortic repair was performed in five patients. The primary endpoint was achieved in all patients (100%). There were no device- or procedure-related complications or no in-hospital major adverse events. The operation time and total blood loss in these cases were equal to those in the manual procedures. The radiation exposure of the surgeon was 96.5% lower than that in the traditional position while the radiation exposure of the patients was not significantly increased.

Conclusions
Early clinical evaluation of the novel endovascular aortic repair in endovascular aortic repair demonstrated practicability, safety, and procedural effectiveness comparable to manual operation. In addition, the total radiation exposure of the operator was significantly lower than that of traditional procedures.

Clinical relevance statement
This study applies a novel approach to perform the endovascular aortic repair in a more accurate and minimal-invasive way and lays the foundation for the perspective automation of the endovascular robotic system, which reflects a new paradigm for endovascular surgery.

Key Points
• This study is a first-in-human evaluation of a novel endovascular robotic system for endovascular aortic repair (EVAR).
• Our system might reduce the occupational risks associated with manual EVAR and contribute to achieving a higher degree of precision and control.
• Early evaluation of the endovascular robotic system demonstrated practicability, safety, and procedural effectiveness comparable to that of manual operation.
Analyse von unerwünschten Arzneimittelwirkungen (UAW) bei Fluoreszeinangiographie (FAG) und Indocyaningrünangiographie (ICGA) und der Indikationsstellung vor und während der COVID-19-Pandemie an einer Universitätsaugenklinik
Authors: Kleefeldt Nikolai , Schneider Anna , Kühnel Sophia , Hillenkamp Jost , William Antony 
Published: June 2023

Zusammenfassung
Hintergrund
Diese Studie ist eine Analyse der Fluoreszeinangiographie (FAG) und der Indocyaningrünangiographie (ICGA) im universitätsmedizinischen Setting, deren primäres Ziel die Analyse der unerwünschten Arzneimittelwirkungen (UAW) und deren Schweregrad (mild, moderat, schwer) ist. Sekundäres Ziel der Studie ist es, die Indikationsstellung von FAG und ICGA vor und während der COVID-19-Pandemie zu untersuchen.

Methodik
Eine retrospektive Analyse aller FAG und ICGA an der Universitätsaugenklinik in Würzburg im Zeitraum von Januar 2016 bis Ende Dezember 2021 wurde durchgeführt. Dabei wurden UAW, Geschlecht, Alter, Untersuchungszeitpunkte und Indikation ausgewertet. Die Einteilung der UAW erfolgte in mild, moderat und schwer, angelehnt an die Definition von Kornblau et al. [1].

Ergebnisse
Insgesamt wurden 4900 Datensätze von 4193 Patienten ausgewertet. Die FAG wurde etwas häufiger bei Männern (54,8 %) als bei Frauen (45,2 %) durchgeführt, und das Durchschnittsalter betrug 63,2 ± 16,9 Jahre (Median: 65 Jahre). UAW traten nur bei 1,65 % aller FAG auf, hiervon waren 1,27 % milde und 0,39 % moderate UAW. Es traten keine schweren UAW auf. Die häufigste UAW war mit 59,26 % eine Nausea. Bei der ICGA traten keine UAW auf. Die jährliche Anzahl der FAG betrug durchschnittlich 816,7 ± 91,1 und war im gesamten Zeitraum bis auf eine signifikant reduzierte Anzahl im Jahr 2016 (im Vergleich zu 2018, 2019 und 2021) relativ konstant. Die häufigste Indikation zur FAG waren venöse retinale Verschlüsse mit 22,93 % (N = 774), hierbei zeigte sich 2021 eine signifikante Zunahme im Vergleich zu den Jahren 2018 bis 2020. Eine ICGA wurde in 4,18 % der Fälle durchgeführt, wobei die häufigste Indikation eine Uveitis mit 31,82 % (N = 63) war.

Diskussion
Im Vergleich zu anderen Studien kam es zu sehr wenigen UAW, und in keinem Fall kam es zu einer lebensbedrohlichen UAW. Venöse retinale Verschlüsse waren sehr häufig die Indikation zur FAG, wahrscheinlich aufgrund der oft notwendigen Wiederholung der Untersuchung bei diesem Krankheitsbild. Kurzzeitig während des ersten Lockdowns (18.03. bis 08.05.2020) konnte eine Abnahme der Angiographien beobachtet werden, aber über einen längeren Zeitraum zeigten sich keine signifikanten Unterschiede im Vergleich zu der Zeit vor der Pandemie.
Efficacy and safety of clonidine for the treatment of impulse control disorder in Parkinson’s disease: a multicenter, parallel, randomised, double-blind, Phase 2b Clinical trial
Authors: Laurencin Chloé , Timestit Noémie , Marques Ana , Duchez Domitille Dilly , Giordana Caroline , Meoni Sara , Huddlestone Marine , Danaila Teodor , Anheim Mathieu , Klinger Hélène , Vidal Tiphaine , Fatisson Marion , Caire Catherine , Nourredine Mikail , Boulinguez Philippe , Dhelens Carole , Ballanger Bénédicte , Prange Stéphane , Bin Sylvie , Thobois Stéphane 
Published: June 2023

Abstract
Background
Impulse control disorders (ICDs) are frequently encountered in Parkinson’s disease (PD).

Objectives
We aimed to assess whether clonidine, an α2-adrenergic receptor agonist, would improve ICDs.

Methods
We conducted a multicentre trial in five movement disorder departments. Patients with PD and ICDs (n = 41) were enrolled in an 8-week, randomised (1:1), double-blind, placebo-controlled study of clonidine (75 μg twice a day). Randomisation and allocation to the trial group were carried out by a central computer system. The primary outcome was the change at 8 weeks in symptom severity using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease–Rating Scale (QUIP-RS) score. A reduction of the most elevated subscore of the QUIP-RS of more than 3 points without any increase in the other QUIP-RS dimension defined success.

Results
Between 15 May 2019 and 10 September 2021, 19 patients in the clonidine group and 20 patients in the placebo group were enrolled. The proportion difference of success in reducing QUIP-RS at 8 weeks, was 7% (one-sided upper 90% CI 27%) with 42.1% of success in the clonidine group and 35.0% in the placebo group. Compared to patients in the placebo group, patients in the clonidine group experienced a greater reduction in the total QUIP-RS score at 8 weeks (11.0 points vs. 3.6).

Discussion
Clonidine was well tolerated but our study was not enough powerful to demonstrate significant superiority compared to placebo in reducing ICDs despite a greater reduction of total QUIP score at 8 weeks. A phase 3 study should be conducted.

Trial Registration
The study was registered (NCT03552068) on clinicaltrials.gov on June 11, 2018.
Hospital-to-home transitions for children with medical complexity: part 2—a core outcome set
Authors: Haspels Heleen N. , de Lange Annemieke A. , Alsem Mattijs W. , Sandbergen Bettina , Dulfer Karolijn , de Hoog Matthijs , Joosten Koen F. M. , van Karnebeek Clara D. , van Woensel Job B. M. , Maaskant Jolanda M. 
Published: June 2023

Abstract
Appropriate outcome measures as part of high-quality intervention trials are critical to advancing hospital-to-home transitions for Children with Medical Complexity (CMC). Our aim was to conduct a Delphi study and focus groups to identify a Core Outcome Set (COS) that healthcare professionals and parents consider essential outcomes for future intervention research. The development process consisted of two phases: (1) a three-round Delphi study in which different professionals rated outcomes, previously described in a systematic review, for inclusion in the COS and (2) focus groups with parents of CMC to validate the results of the Delphi study. Forty-five professionals participated in the Delphi study. The response rates were 55%, 57%, and 58% in the three rounds, respectively. In addition to the 24 outcomes from the literature, the participants suggested 12 additional outcomes. The Delphi rounds resulted in the following core outcomes: (1) disease management, (2) child’s quality of life, and (3) impact on the life of families. Two focus groups with seven parents highlighted another core outcome: (4) self-efficacy of parents. Conclusion: An evidence-informed COS has been developed based on consensus among healthcare professionals and parents. These core outcomes could facilitate standard reporting in future CMC hospital to home transition research. This study facilitated the next step of COS development: selecting the appropriate measurement instruments for every outcome.

What is Known:• Hospital-to-home transition for Children with Medical Complexity is a challenging process.• The use of core outcome sets could improve the quality and consistency of research reporting, ultimately leading to better outcomes for children and families.

What is New:• The Core Outcome Set for transitional care for Children with Medical Complexity includes four outcomes: disease management, children’s quality of life, impact on the life of families, and self-efficacy of parents.
Artificial Intelligence in Surgical Documentation: A Critical Review of the Role of Large Language Models
Authors: Lawson McLean Aaron 
Published: June 2023

AbstractThis article provides a critical analysis of the application of the advanced language
model, GPT-4, in generating surgical operative notes, with a focus on its use in
ophthalmology as presented by Waisberg et al. The discussion underscores the
inherent complexity and specificity of operative notes, the issue of accountability, and
the potential data protection issues associated with the use of AI in healthcare. The
letter emphasizes the need for a more comprehensive understanding of the
complexities involved in applying AI in healthcare and calls for a more nuanced and
responsible approach to the integration of AI in surgical documentation.