bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast ultrasound diagnostic performance and outcomes for mass lesions in Dharma Yadnya general hospital in 2018-2023
Authors: Dana I. Made Bayu Surya , Atmaja I. Nyoman Teri 
Published: June 2023

Background: The latest report by the world health organization and international agency for research on cancer told that the incidence and mortality of breast cancer is the most among female cancer patients.
Methods: This is descriptive study which uses medical record of 50 samples patients in Dharma Yadnya general hospital. This study include patients at least 25 years old who presented to the Dharma Yadnya general hospital between January 2019 to March 2023 which get breast ultrasound examination and pathology examination, benign or malignant mass.
Results: In ultrasound findings, there are 43 (86%) people with benign cancer, 7 (14%) people with malignant cancer, 43 (86%) people with hipoechoic density and solid lession, 7 (14%) people with isoechoic density and cystic lession, 43 (86%) people with regular margin, 7 (14%) people with irregular margin, 43 (86%) people without lymph nodes axillary, 7 (14%) people with lymph nodes axillary, and by Doppler there are 43 (86%) people without neovascularitation inside lession and 7 (14%) people with neovascularitation inside lession. There are statistically significant relationship (p<0.05) between diagnosis (benign and malignant) with age of patients, density, margin, existence of lymph nodes axillary, and neovascularitation inside the lession by doppler.
Conclusions: Breast sonography is the modality of choice for further investigation of palpable breast findings that are not clearly benign and mammographic screen-detected abnormalities.
Fârâbî’nin Yetkinlik Metafiziği Açısından Kelâm
Authors: KALYONCU Rıza Tevfik 
Published: June 2023

Bu makalede Fârâbî metafiziğinin genel yapısı içerisinde kelâm ilminin konumu incelenmektedir. Makale iki bölümden oluşmaktadır. Birinci kısımda Fârâbî’nin yetkinleşme düşüncesi çerçevesinde metafiziğin pozisyonu üzerinde durulmaktadır. İkinci kısımda ise Fârâbî’nin el-İbâne ʿan ġarażi Arisṭoṭâlîs fî kitâbi mâ baʿde’ṭ-ṭabîʿa eserinin yakın bir okuması yapılmakta ve Fârâbî’nin mille teorisi dahilinde kelâm ilminin nazarîliği ile ilgili yaklaşımı analiz edilmektedir. Makalede yetkinleşme ve anlam teorilerinin Fârâbî’nin felsefesindeki genel konumu irdelenmeksizin bu iki teorinin Fârâbî’nin metafizik ve kelâm ile ilgili analizlerindeki etkileri üzerinde durulmaktadır. Makalede Fârâbî metafiziğinin onun yetkinleşme ve anlam teorileri arka planında değerlendirilmesi gerektiği düşüncesi, konuyla ilgili ikincil literatür dikkate alınarak irdelenmektedir. Bu iddiaya delil olarak Fârâbî’nin felsefî ilimleri aklî yetkinleşmenin basamakları olarak tarif etmesi ele alınmaktadır. Özellikle Taḥṣîlü’s-saʿâde, Risâle fi’l-‘aḳl ve Kitâbü’l-Ḥurûf eserlerindeki ilgili pasajların yakın bir okuması yapılarak Fârâbî’nin yetkinleşme ve anlam teorilerinin metafizik ile ilgili analizlerinin arka planını nasıl oluşturduğu filozofun argümanları üzerinden açıklanmaktadır.
Diğer taraftan makalede el-İbâne eserinin Fârâbî’nin metafizik kurgusu içerisinde nasıl değerlendirilmesi gerektiği yetkinleşme ve anlam teorilerinin bu eserdeki uzanımları aktarılmaktadır. Bu eser ile ilgili olarak ikincil literatürde farklı yorumlar yapılmıştır. Makalede bu yorumlar bağlamında Fârâbî’nin yetkinleşme ve anlam teorileri çerçevesinde eserin metafizik ilminin mahiyeti ile ilgili kısımları analiz edilmektedir. Zira Fârâbî açısından aklî yetkinleşmenin son basamağını oluşturan metafizik aynı zamanda en yüksek ilimdir. Bu durum Fârâbî’nin “nazar-ı ilâhî” kavramıyla birçok kez ifade edilmektedir. Kelâm bu çerçevede aklî yetkinleşme içerisinde ortaya çıkmayan bir ilim olması nedeniyle metafizik olma vasfı kazanamaz. Yetkinleşme teorisinin Fârâbî’nin metafizik ve kelâm ile ilgili düşüncelerine etkisi konu ile ilgili yapılan çalışmalarda ifade edilmektedir. Bu makalede ise yetkinleşme ve anlam teorileri metafiziğin ve kelâm ilminin konumu ile ilgili olarak el-İbâne eserindeki pasajlar üzerinden tahlil edilmektedir. Fârâbî’nin bu eserindeki ilâhî ilim ve metafizik arasındaki ayrımı araştırmacılar arasında tartışma konusu olmuştur. Makale metafiziğin yetkinleşme ve anlam teorilerinin Fârâbî'nin küllî ilim yaklaşımını etkilediği üzerinde durmaktadır. Makalenin son bölümünde Fârâbî'nin mille teorisi anlam teorisi zemininde ele alınmaktadır. Bu amaçla makalede, Fârâbî’nin felsefenin bir kopyası ya da benzeri olarak mille düşüncesinin, kelâm ilmini sözel anlam alanı ile felsefî anlam alanı arasında hareket eden bir ara ilim haline getirdiği ileri sürülmektedir.
Functional Performance and Community Reintegration of Chronic Post-stroke Survivors in Eastern India
Authors: Mohakud Kshanaprava , Das Sakti Prasad , Sahoo Surjeet , Sahu Samir 
Published: June 2023

Introduction: Stroke is the primary cause of functional dependency in daily activities leading to disability of the individual. It becomes an economic burden for the person and society. Post-stroke management in rehabilitation gives more emphasis on improving functional performance. The improvement in functional activities of post-stroke survivors makes them independent in their daily activities at home but, still an impediment exists to participate in society and reintegrating into the community. The objective of the study is to find the association of community reintegration with the functional performance of one-year post-stroke survivors in eastern India and to compare their functional independence, community reintegration, and participation in instrumental daily living activities between stroke affection side and stroke subtype of the study group.
Materials and Methods: A cross-sectional observational study was carried out on post-stroke survivors between 30 and 60 years of age without sex barrier. Ninety-four patients (mean age 54.38±12.06) were recruited for the study. The outcome was measured by the community integration questionnaire (CIQ), Lawton instrumental activities of daily living (LIADL), and functional independence measure (FIM).
Results: Spearman rank order correlation was used and found a significant positive correlation persists between FIM to CIQ as the r=0.565 (P=0.01, 95% CI, -0.40%-0.70%) and LIADL to CIQ r=0.687 (P=0.01, 95% CI, -0.55%-0.79%) FIM to LIADL r=0.532 (P=0.01, 95% CI,
-0.36%-0.67%). Mann-Whitney U test was done to compare FIM, LIADL, and CIQ between stroke affection side (right vs left) and stroke sub-type (ischemic vs haemorrhagic), and no significant difference was found.
Conclusion: Functional independence, instrumental activities of daily living, and community reintegration are associated with each other. Hence, community reintegration should be incorporated into stroke rehabilitation to maintain a meaningful life as a part of society and family.
ANALISIS FAKTOR PENYEBAB PENGGUNAAN KONTRASEPSI SELAMA MASA PANDEMI COVID-19 PADA PASANGAN USIA SUBUR DI KECAMATAN TEBING TINGGI KABUPATEN TANJUNG JABUNG BARAT
Authors: Nurma Dian Aprilia 
Published: June 2023

Laju pertumbuhan penduduk di Indonesia mengalami peningkatan sebesar 1,49% atau bertambah 4,5 juta setiap tahunnya. Hal ini menyebabkan tidak sesuainya program pemerintah dalam menggalakkan program Keluarga Berencana (KB). Program KB mengalami penurunan selama masa pandemi COVID-19, hal ini disebabkan karena fasilitas kesehatan yang akan di akses masyarakat untuk mendapatkan program KB terbatas. Badan Kependudukan dan Keluarga Berencana Nasional mencatat adanya penurunan drastis (35%-47%) pada penggunaan kontrasepsi, berkurangnya partisipasi penggunaan KB, dan akan berimbas kepada meningkatnya kelahiran bayi atau biasa disebut sebagai kejadian “baby boom” setelah pandemi COVID-19. Berdasarkan survei awal yang dilakukan kepada Pasangan Usia Subur (PUS) di Kecamatan Tebing Tinggi, terjadi penurunan penggunaan kontrasepsi sebesar 21,5% selama masa pandemi COVID-19. Penelitian ini bertujuan untuk mengetahui faktor penyebab partisipasi penggunaan kontrasepsi selama masa pandemi COVID 19. Penelitian ini menggunakan desain cross sectional dengan analisis univariat dan analisis bivariat. Metode uji yang digunakan adalah chi square. Sampel penelitian adalah Pasangan Usia Subur (PUS) di Kecamatan Tebing Tinggi dipilih berdasarkan metode simple random sampling. Hasil penelitian menunjukkan bahwa terdapat tiga variabel yang berhubungan dengan penggunaan kontrasepsi yaitu pengetahuan (p-value <0.001), dukungan suami (p-value <0.001) dan dukungan tenaga kesehatan (p-value <0.001). Jadi sangat disarankan para suami dapat memberikan dukungan kepada istri terkait penggunaan kontrasepsi, tenaga kesehatan juga berperan dalam memberikan dukungan fasilitas dan tenaga dalam memberikan pelayanan KB kepada akseptor KB. Penyuluh KB dan kader KB di setiap desa/kelurahan dapat memberikan Komunikasi Informasi dan Edukasi (KIE) kepada akseptor terkait kontrasepsi yang dapat meningkatkan jumlah akseptor KB.
Humeral Head Avascular Necrosis
Authors: Cehelyk Eli K. , Stull Justin D. , Patel Manan S. , Cox Ryan M. , Namdari Surena 
Published: June 2023

» Avascular necrosis (AVN) of the humeral head is the result of ischemic injury to the epiphyseal bone leading to humeral head collapse and arthritis.» Common causes include trauma, chronic corticosteroid use, or systemic disease processes, such as sickle cell disease, systemic lupus erythematosus, or alcohol abuse.» Nonoperative treatment consists of risk factor management, physical therapy, anti-inflammatory medications, and activity modification.» Surgical treatment options include arthroscopic debridement, core decompression, vascularized bone grafts, and shoulder arthroplasty.
Multiple-Point Geostatistical Simulation of Nonstationary Sedimentary Facies Models Based on Fuzzy Rough Sets and Spatial-Feature Method
Authors: Zhang Dailu , Zhang Hongbing , Ren Quan , Zhao Xiang 
Published: June 2023

Summary
3D simulation of sedimentary facies using seismic data is vital for reservoir evaluation and estimation of oil and gas reserves. As a result of the high nonstationarity of sedimentary facies and the highly nonlinear characteristics of seismic attributes, the mapping relationship with sedimentary facies has certain ambiguities and uncertainties that affect the modeling results of sedimentary facies. Multipoint geostatistics (MPS) has proven to be an effective technique for modeling subsurface geological bodies. However, the conventional MPS only deals with stationary applications, and its capability of revealing the distribution of sedimentary facies is thereby limited. In addition, the task of seismic attributes selection, which significantly affects the performance of the modeling method in simulating the distribution of sedimentary facies, is difficult because the relationship between sedimentary facies and seismic attributes is complex. This article presents a nonstationary modeling method for simulating the distribution of sedimentary facies, which is featured by the multiscale spatial feature of patterns. In particular, the spatial location of the patterns is introduced as auxiliary information in the classification and simulation processes. The method incorporates multiscale results during the modeling procedure. Patterns from the multicategory training images (TIs) are classified by the optimized workflow. The seismic attribute selection is achieved by using fuzzy-rough sets. The proposed simulation method is verified by two typical TIs, followed by applications to predict the actual distribution of sedimentary facies. Compared with the filter-based pattern simulation (FILTERSIM) approach, the proposed simulation method is applicable for revealing detailed subsurface models, especially under complex geological conditions and limited information.
WITHDRAWN: Feasibility of using Gag proteins to reawaken dormant HIV infection based on bioinformatics analysis
Authors: Chen S. 
Published: June 2023

Abstract

The technique of using drugs to target latent virus reservoirs has been introduced to reawaken dormant viruses such that the immune system can attack them, but further tests have shown this method fails. In this study, the author attempted to analyze whether drugs can be used to reawaken dormant virus reservoirs and proposed the use of viral proteins to activate the sleeping virus. The results show that the amino acid sequence ARG of Gag proteins of HTLV-1, HTLV-2, STLV-1 and STLV-2 match their primer binding site GGGGGCTCG in the 3'-to-5' direction and that the amino acid sequence SPR of Gag proteins of HIV-1, HIV-2, SIV and FIV match their primer binding site GGCGCCCGA in the 3'-to-5' direction. The author hence believes that the latency-reversing drugs are involved in the process of the transcription of cancer genes, and because the virus genome they reawaken contains the same NF-κB binding sites, the drugs indirectly reawaken dormant retrovirus infection. Related studies showed that the genomic Gag/Gag-Pol complex recruits the LysRS/tRNA complex, the selective packaging of the tRNA primer requires HIV-1 Gag and Gag-Pol, and an interaction between LysRS and Gag is observed in vitro. In contrast, Gag proteins can more reliably be used to directly reawaken dormant HIV infection, which recruits human uncharged tRNA to serve as the reverse transcription primer.
Comparison of temporary external and percutaneous k-wire fixations for treatment of ankle fracture–dislocations
Authors: Xie Wenjun , Li He , Zhang Cheng , Cui Xueliang , Zhang Sheng , Rui Yunfeng , Chen Hui 
Published: June 2023

Abstract

Purpose Ankle fracture–dislocations are among the most severe injuries, and the use of an external fixator as a recommended fixation method has some disadvantages. The aim of this study was to compare the clinical outcomes and complication rates of external and K-wire fixations in the treatment of ankle fracture dislocations. Methods A total of 67 patients with ankle fracture–dislocations requiring temporary external or percutaneous K-wire fixation were included. The exclusion criteria were pilon fractures, open fractures, and those who required acute open reduction internal fixation (ORIF). The American Orthopaedic Foot and Ankle Society (AOFAS) ankle–hindfoot score, a 10-point visual analog scale (VAS) score (range 0–10), and complications before and after the definitive surgery were recorded. Results A significant difference between the two groups was not observed for age, sex, affected side, fracture type, smoking status, or diabetes. The average AOFAS scores were 83.2 and 83.3, the median VAS scores were 3 and 3, and the complication rates were 32.4% and 6.7% in the external and K-wire fixation groups, respectively (p = 0.010). However, skin necrosis, re-dislocation of the ankle, surgical wound infection, and posttraumatic ankle osteoarthritis frequency were not significantly different between the groups, except for pin-sites infection (p = 0.036). Conclusion Ankle fracture–dislocations using percutaneous k-wire fixation showed a low rate of complications and favorable clinical outcomes. This method could be a good alternative treatment option for ankle fracture-dislocations.
Aged care services as facilitators of delayed inclusion – An analysis of institutional discourses on service provision for older migrants in Germany
Authors: Goettler Andrea , Willis Rosalind 
Published: June 2023

Abstract

Background: Migration within and to Europe in the past decades has led to a growing diversity and a rising proportion of migrants in the older population. Germany has encouraged labour migration since the 1960s and many migrants who arrived for work in the past decades decided to stay and are now growing old in Germany. Health and social care institutions intend to acknowledge this change and adapt to the cultural diversity in aged care. This process can also be observed in the city of Munich, which is characterised by a high percentage of citizens with a migration background and an increasing population of older migrants.
Methods: This study examines discourses on older migrants and their access to health and social care in Germany, associated challenges and proposed solutions. Problem-centred interviews were carried out with 18 professionals from public, welfare and charity organisations who develop, organise or provide aged care services for older migrants. The analysis examines the narratives of migrant representations, constructions of healthy ageng and phenomenal structures of services provision following the sociology of knowledge approach to discourse (SKAD) research programme.
Results: The discourses on older migrants in public and social care institutions demonstrate how being defined as a migrant is related to cultural, socioeconomic and language difference and particularly stresses the structural challenges labour migrants experienced throughout and after employment. Thus, improving accessibility to health and social care is presented as a public responsibility, which aims to recognise the increasing diversity in older age and to create low threshold access to these services.
Conclusions: Recognising the increasing diversity in older age by implementing diversity sensitive frameworks and improving accessibility to health and social care services could provide an opportunity for (delayed) inclusion in public services for older migrants.
Psilocybin decelerates cellular senescence
Authors: Hecker Louise , kato kosuke , Kleinhenz Jennifer M. Kleinhenz , Shin Yoon-Joo , Papageorgiou John , Zarrabi Ali 
Published: June 2023

Abstract
Psilocybin is the psychoactive substance contained in the psilocybe(hallucinogenic) mushroom, which has received considerable attention among the scientific community in recent years. Human studies have demonstrated that even a single-dose of psilocybin can improve debilitating physical and psychological symptoms with durable long-term effects. >136 clinical studies with psilocybin have been completed or are ongoing for various indications, including psychiatric, neurodegenerative, chronic pain, and more. However, despite considerable clinical evidence for the therapeutic effects, the underlying molecular mechanisms responsible for its beneficial actions remain enigmatic. Studies with psilocybin have overwhelmingly focused on neurological impacts and/or behavioral outcomes; however, few studies have evaluated other mechanisms by which it exerts beneficial effects. It has recently been hypothesized that psilocybin may exert beneficial effects on aging; however, no studies have experimentally investigated the impact of psilocybin on senescence/aging. Using a previously validated human cell model of replicative senescence in vitro, cells were treated with psilocybin continuously throughout their replicative cellular lifecycle. Psilocybin treatment led to a dose-dependent decrease in cell-cycle arrest markers, increased markers of DNA replication and proliferation, reduced senescence-associated secretory phenotype (SASP), and reduced oxidative stress levels. Further, psilocybin did not demonstrate senolytic activity. Overall, these data are the first experimental evidence suggesting that psilocybin may decelerate the process of cellular senescence. Given that senescence and inflammation contribute to the pathogenesis of numerous age-related diseases, these studies could lay the foundation for the use of psilocybin as a therapeutic strategy for many age-related disease indications and/or as a geroprotective agent.
Dietary protein in early pregnancy and gestational diabetes mellitus: a prospective cohort study
Authors: luo tingyu , Wei Hui-xin , Chen Hong-yan , Yang Yi-ling , Wei Feng-xiang , Chen Wei-qiang 
Published: June 2023

Abstract
Purpose The relationship between dietary protein intake and the risk of gestational diabetes mellitus (GDM) remains inconsistent and unclear. Here, we examined the correlation between the various sources of protein intake among Chinese pregnant women and GDM.Methods This prospective cohort study included 1060 pregnant women at 6–13+ 6 weeks of gestation from Guangdong Provincial Hospital for Women and Children, South China. The participants' intake of dietary protein was assessed using a validated quantitative food frequency questionnaire during the early trimester. GDM was diagnosed via an oral glucose tolerance test performed at 24–28 gestational weeks. Logistic regression analysis was used to evaluate the association between dietary protein intake during pregnancy and GDM. Furthermore, we applied restricted cubic splines to determine their linear relationship.Results About 26.3% (n = 279) of pregnant women were diagnosed with GDM. Animal protein intake was revealed to have a positive correlation with GDM risk (Q4 vs. Q1: OR, 2.78; 95% CI, 1.46–5.34; P = 0.015), whereas high intake levels of dietary plant protein were linked to reduced GDM risk (Q4 vs. Q1: OR, 0.43; 95% CI, 0.25–0.73). In stratified analysis, the relationship between protein and GDM was stronger during early pregnancy in women with obesity. However, total protein intake did not show a significant association with GDM.Conclusions Our study findings suggest that a plant protein-based diet was associated with reduced GDM risk, whereas the dietary intake of animal protein was positively associated with GDM risk among Chinese women during early pregnancy.
Allosteric inhibition of IgE–FcεRI interactions by simultaneous targeting of different epitopes on IgE F(ab’)2
Authors: Koyanagi Akemi , Ago Hideo , Yamamoto Masaki , Kitaura Jiro , Kasai Masataka , Okumura Ko , Hirano Takao 
Published: June 2023

Abstract

Immunoglobulin E (IgE) plays pivotal roles in allergic diseases through interaction with a high-affinity receptor (FcεRI). We established that Fab fragments of anti-IgE antibodies (HMK-12 Fab) rapidly dissociate preformed IgE-FcεRI complexes in a temperature-dependent manner and inhibit IgE-mediated anaphylactic reactions, even after an allergen challenge. X-ray crystallographic studies revealed that the light and heavy chains of HMK-12 Fab interact with the Cε2 homodimer domain and light chain of IgE F(ab’)2, respectively. Consequently, complex formation resulted in a decrease in the asymmetric structural features of IgE Fc domains and the dissociation of IgE. This unexpected finding of the allosteric inhibition of IgE-FcεRI interactions by simultaneous targeting of different epitopes on IgE F(ab’)2 has implications for the development of novel therapies for allergic diseases.