bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dampak Pengembangan Desa Wisata Terhadap Sosial Ekonomi Masyarakat
Authors: Aminuddin Haris , Dhora Nailufar Faza , Alexander Mujiburrohman M 
Published: February 2023

Tujaun penelitian ini adalah ingin mendeskripsikan dinamika partisipasi masyarakat, dampak pengembangan desa wisata terhadap perekonomian, sosial perekonomian, di Desa Carangwulung. Penelitian ii meripakan penel;itian deskriptif dengan pendekatan kualitatif. Fokus pada penelitian ini adalah tentang : Pengembangan pariwisata di Kabupaten Jombang dengan perspektif pembangunan berkelanjutan, Dampak pengembangan pariwisata di Kabupaten Jomabng terhadap sosial ekonomi.Lokasi penelitian ini dilakukan di lingkungan Desa Carangwulung Kecamatan Wonosalam Kabupaten Jombang pada Kampung Adat Dusun Segunung Desa Carangwulung. Teknik pengumpulan data penelitian ini yaitu observasi, interview, dokumentasi, dan gabungan ketiganya (triangulasi). Dalam penelitian ini, metode analisis yang digunakan adalah metode deskriptif dengan pendekatan kualitatif yang meliputi analisa-analisa berdasarkan obyek penelitian yang telah disusun sebelumnya sehingga penelitian ini dapat lebih terarah. Hasil penelitian ini adalah 1. Kawasan wisata desa wisata wonosalam memiliki daya tarik tersendiri bagi wisatawan, selain karena pemandangan yang indah juga terdapat wahana yang menantang. 2. Dampak dari kehadiran objek desa wisata wonosalam yaitu meningkatnya interaksi sosial dengan orang-orang baru, persaingan antar pedagang yang mengharuskan mereka saling berinteraksi dalam menjalankan usaha yang mereka jalani. 3. Efek dari adanya desa wisata wonosalam menambah pendapatan masyarakat sekitar baik itu melalui berdagang atau menjadi pengelolah yang mengawasi wahana di desa wisata wonosalam Hal ini memicu bertambahnya pendapatan ekonomi masyarakat tersebut.
Implementasi internet of things (iot) web server smarthome
Authors: Pratama Robby Irwan , Ardianto Feby , Alfaresi Bengawan , Sofijan Armin , Ariyanto Eko 
Published: February 2023

Pemborosan bisa terjadi karena penggunaan listrik rumah tangga yang tidak terkontrol, mengefesienkan penggunaan listrik serta keamanan, kenyamanan pengguna diperlukan pengendali jarak jauh yang digunakan peralatan pengendali dengan memanfaatkan teknologi informasi dengan internet sebagai sumber pengendalinya Penelitian bertujuan untuk mengimplementasi internet of things (IoT) sebagai pengendali peralatan listrik rumah tangga berbasis web dengan konsep rumah pintar (smarthome). Metode penelitian dilakukan dengan empat tahapan, yaitu : 1). software dan hardware 2). Desain web 3). Pembuatan program 4). Pengujian. Hasil penelitian menunjukan bahwa smarthome dapat dikendalikan menggunakan host 192.168.43.212 dan 192.168.43.213dan menggunakan jaringan LAN dan modul wifi esp 8266 digunakan untuk mengontrol kipas, lampu, garasi, pintu dan pagar berjalan dengan baik
Pharmaceutical and personal care products (PPCPs) as endocrine disrupting contaminants (EDCs) in South African surface waters
Authors: Archer Edward , Wolfaardt Gideon , H. Van Wyk Johannes 
Published: February 2023

<p>Globally, water resources are under constant threat of being polluted by a diverse range of man-made chemicals, and South Africa is no exception. These contaminants can have detrimental effects on both human and wildlife health. It is increasingly evident that several chemicals may modulate endocrine system pathways in vertebrate species, and these are collectively referred to as endocrine disrupting contaminants (EDCs). Although the endocrine-disrupting effect of water pollutants has been mainly linked to agricultural pesticides and industrial effluents, other pollutants such as pharmaceuticals and personal care products (PPCPs) are largely unnoticed, but also pose a potentially significant threat. Here we present for the first time in a South African context, a summarised list of PPCPs and other EDCs detected to date within South African water systems, as well as their possible endocrine-disrupting effect in-vitro and in-vivo. This review addresses other factors which should be investigated in future studies, including endocrine disruption, PPCP metabolites, environmental toxicology, and antibiotic resistance. The challenges of removing EDCs and other pollutants at South African wastewater treatment works (WWTWs) are also highlighted. The need for focused research involving both in-vitro and in-vivo studies to detect PPCPs in water systems, and to delineate adverse outcome pathways (AOPs) of priority PPCPs to aid in environmental impact assessment (EIA), are discussed. </p>
UPAYA MENINGKATKAN PEMAHAMAN PESERTA DIDIK PADA MATERI CARITA PONDOK MELALUI MODEL PEMBELAJARAN PROBLEM BASED LEARNING
Authors: Yuanita Tika , Nurhayati Lestari Tika 
Published: February 2023

Penelitian ini bertujuan untuk mengetahui bagaimana upaya meningkatkan pemahaman peserta didik pada materi carita pondok melalui model pembelajaran problem based learning. Metode penelitian yang digunakan adalah penelitian tindakan kelas (PTK). Metode ini dilakukan melalui 4 tahapan, yakni perencanaan, pelaksanaan, pengamatan dan refleksi. Instrumen yang digunakan adalah lembar observasi peserta didik, instrumen tes, dan catatan lapangan. Hasil Penelitian menunjukkan bahwa nilai rata-rata hasil tes pemahaman peserta didik diakhir siklus I adalah 62, kemudian meningkat menjadi 74 di akhir siklus II. Sedangkan persentase aktivitas peserta didik mengalami peningkatan, yakni dari siklus I 63,35% dan di siklus II menjadi 82,13%. Dengan demikian dapat disimpulkan bahwa penggunaan model pembelajaran problem based learning dapat meningkatkan pemahaman peserta didik pada materi
ANALISIS DAYA TARIK IKLAN POP-UP YOUTUBE DI KALANGAN MAHASISWA
Authors: Pratama Devin Rizky , Gushevinalti . 
Published: February 2023

Pendekatan penelitian ini adalah pendekatan kualitatif yang bersifat deksriptif. Proses pengumpulan data dilakukan dengan wawancara, observasi yang sudah dituliskan dalam catatan lapangan, dokumen pribadi, dokumen resmi, gambar foto dan sebagainya. Uji keabsahan data menggunakan teknik triangulasi data, dengan cara memeriksa data yang telah diperoleh melalui beberapa sumber. Teori yang dipakai dalam penelitian ini menggunakan teori AIDDA (Attention, Interest, Desire, Decision, Action) oleh Wilbur Schramm. Tujuan penelitian ini adalah untuk mengetahui dan menganalisis daya tarik iklan pop-up dalam kalangan mahasiswa. Ketertarikan untuk menonton iklan pop-up muncul ketika iklan yang tayang memiliki unsur – unsur yang dapat menangkap perhatian dari mahasiswa. Hasil penelitian menunjukkan bahwa setelah iklan tersebut berhasil mendapatkan perhatian, maka secara otomatis mahasiswa memiliki ketertarikan terhadap apa yang diiklankan lalu melanjutkan tahapan selanjutnya seperti menunjukkan keinginan, membuat keputusan, lalu melakukan tindakan.
FABRICATION AND CONTROLLING MORPHOLOGY OF POLYETHYLENE OXIDE/SODIUM ALGINATE BEADS AND/OR FIBERS: EFFECT OF VISCOSITY AND CONDUCTIVITY IN ELECTROSPINNING
Authors: EREN BÖNCÜ Tuğba 
Published: February 2023

Objective: The aim of the study is to determine the viscosity and conductivity of PEO/NaAlg polymer solutions, to formulate PEO/NaAlg beads, bead-on-string fibers and fibers via electrospinning, and to perform advanced morphological characterization studies on them.
Material and Method: Effect of PEO and NaAlg concentration and ratio of them on spinnability, viscosity and conductivity of solutions, and also on the morphological properties of PEO/NaAlg electrospun fibers, and beads (length, width and aspect ratio of beads, number of beads and bead area) were investigated.
Result and Discussion: As a result, electrospun materials were produced using PEO/NaAlg beads and/or fibers, which are valuable for medical and biological applications such as tissue engineering, wound dressing, drug delivery system. Viscosity and conductivity of solutions, and morphological properties of the obtained materials were found to be affected by PEO and NaAlg concentration and the ratio of them. Spinnability was improved thanks to the increase in conductivity in the presence of PEO. The lower viscosity and conductivity resulted in the production of beads that were generally smaller and greater in number in the material and having higher area. The morphological properties of PEO/NaAlg electrospun materials can be modified by controlling the parameters examined in the study.
Phosphoric acid pretreatment of poplar to optimize fermentable sugars production based on orthogonal experimental design
Authors: Chen Deming , Tang Wenjing , Wang Hui , Sheng Yequan , Tan Xin , Shi Yang , Fan Wei , Ge Shengbo 
Published: February 2023

The recalcitrant structure of raw poplar limited the production of fermentable sugars when applied as the material in the pretreatment of biochemical conversions. Phosphoric acid pretreatment is an efficient method to destroy the compact lignocellulose matrix presence in the poplar. In this study, phosphoric acid pretreatment of poplar was optimised by an orthogonal experimental design [L9(33)] to improve enzymatic digestibility through investigating the effects of reaction temperature, time duration, and phosphoric acid concentration. The optimal conditions were selected based on the variance of chemical compositions, hemicellulose removal ratio, and delignification of the woody material after pretreatment. The optimum enzymatic hydrolysis yield of up to 73.44% was obtained when the phosphoric acid pretreatment performed at 190°C for 150 min under 1.5% of v/v phosphoric acid concentration.
Analysis of the amplified p-wave enables identification of patients with atrial fibrillation during sinus rhythm
Authors: Huang Taiyuan , Schurr Patrick , Muller-Edenborn Bjoern , Pilia Nicolas , Mayer Louisa , Eichenlaub Martin , Allgeier Juergen , Heidenreich Marie , Ahlgrim Christoph , Bohnen Marius , Lehrmann Heiko , Trenk Dietmar , Neumann Franz-Josef , Westermann Dirk , Arentz Thomas , Jadidi Amir 
Published: February 2023

AimThis study sought to develop and validate diagnostic models to identify individuals with atrial fibrillation (AF) using amplified sinus-p-wave analysis.MethodsA total of 1,492 patients (491 healthy controls, 499 with paroxysmal AF and 502 with persistent AF) underwent digital 12-lead-ECG recording during sinus rhythm. The patient cohort was divided into training and validation set in a 3:2 ratio. P-wave indices (PWI) including duration of standard p-wave (standard PWD; scale at 10 mm/mV, sweep speed at 25 mm/s) and amplified sinus-p-wave (APWD, scale at 60–120 mm/mV, sweep speed at 100 mm/s) and advanced inter-atrial block (aIAB) along with other clinical parameters were used to develop diagnostic models using logistic regression. Each model was developed from the training set and further tested in both training and validation sets for its diagnostic performance in identifying individuals with AF.ResultsCompared to standard PWD (Reference model), which achieved an AUC of 0.637 and 0.632, for training and validation set, respectively, APWD (Basic model) importantly improved the accuracy to identify individuals with AF (AUC = 0.86 and 0.866). The PWI-based model combining APWD, aIAB and body surface area (BSA) further improved the diagnostic performance for AF (AUC = 0.892 and 0.885). The integrated model, which further combined left atrial diameter (LAD) with parameters of the PWI-based model, achieved optimal diagnostic performance (AUC = 0.916 and 0.902).ConclusionAnalysis of amplified p-wave during sinus rhythm allows identification of individuals with atrial fibrillation.
Efficacy of unblinded and blinded intermittently scanned continuous glucose monitoring for glycemic control in adults with type 1 diabetes
Authors: Guo Lixin , Li Yuxiu , Zhang Mei , Xiao Xinhua , Kuang Hongyu , Yang Tao , Jia Xiaofan , Zhang Xianbo 
Published: February 2023

ObjectiveIntermittently scanned continuous glucose monitoring (isCGM) is used for unblinded or blinded monitoring of interstitial glucose. We aimed to compare the efficacy of blinded and unblinded isCGM with the FreeStyle Libre system for glycemic control in adults with type 1 diabetes (T1D).Research design and methodsThis randomized clinical trial conducted between October 2018 and September 2019 across four endocrinology practices in China included 273 adults aged ≥18 years with T1D, who were randomly divided in a 2:1 ratio into the unblinded (n = 199) or blinded isCGM group (n = 78). In the blinded group, the clinician used FreeStyle Libre Pro system for monitoring, but self-monitoring was also performed by the patients.ResultsTwo hundred sixteen (78%) participants completed the study (152 [75%] in the unblinded and 64 [82%] in the blinded group). At 12 weeks, a significant increase in TIR (3.9-10.0 mmol/L) was only observed in the unblinded group, along with a significant decrease in hyperglycemia (&gt;13.9 mmol/L), hypoglycemia (&lt;3.0 mmol/L), glycemic variability. Further, the mean HbA1c reduction from baseline to 12 weeks was 0.5% in the unblinded isCGM group and 0.4% in the blinded isCGM group respectively (P &lt; 0.001), but the significance did not remain after adjustment for between-group differences. Finally, 99.5% of the blinded isCGM values and 93.8% the of unblinded isCGM values were obtained at the final visit.ConclusionsThe unblinded isCGM system was associated with benefits for glucose management, but nearly 100% of the attempted profiles were obtained successfully with the blinded isCGM system. Thus, combining real-time and retrospective data with isCGM might be the most impactful way to utilize flash glycemic monitoring devices.
Identifying patients with acute ischemic stroke within a 6-h window for the treatment of endovascular thrombectomy using deep learning and perfusion imaging
Authors: Gao Hongyu , Bian Yueyan , Cheng Gen , Yu Huan , Cao Yuze , Zhang Huixue , Wang Jianjian , Li Qian , Yang Qi , Wang Lihua 
Published: February 2023

IntroductionIt is critical to identify the stroke onset time of patients with acute ischemic stroke (AIS) for the treatment of endovascular thrombectomy (EVT). However, it is challenging to accurately ascertain this time for patients with wake-up stroke (WUS). The current study aimed to construct a deep learning approach based on computed tomography perfusion (CTP) or perfusion weighted imaging (PWI) to identify a 6-h window for patients with AIS for the treatment of EVT.MethodsWe collected data from 377 patients with AIS, who were examined by CTP or PWI before making a treatment decision. Cerebral blood flow (CBF), time to maximum peak (Tmax), and a region of interest (ROI) mask were preprocessed from the CTP and PWI. We constructed the classifier based on a convolutional neural network (CNN), which was trained by CBF, Tmax, and ROI masks to identify patients with AIS within a 6-h window for the treatment of EVT. We compared the classification performance among a CNN, support vector machine (SVM), and random forest (RF) when trained by five different types of ROI masks. To assess the adaptability of the classifier of CNN for CTP and PWI, which were processed respectively from CTP and PWI groups.ResultsOur results showed that the CNN classifier had a higher performance with an area under the curve (AUC) of 0.935, which was significantly higher than that of support vector machine (SVM) and random forest (RF) (p = 0.001 and p = 0.001, respectively). For the CNN classifier trained by different ROI masks, the best performance was trained by CBF, Tmax, and ROI masks of Tmax &gt; 6 s. No significant difference was detected in the classification performance of the CNN between CTP and PWI (0.902 vs. 0.928; p = 0.557).DiscussionThe CNN classifier trained by CBF, Tmax, and ROI masks of Tmax &gt; 6 s had good performance in identifying patients with AIS within a 6-h window for the treatment of EVT. The current study indicates that the CNN model has potential to be used to accurately estimate the stroke onset time of patients with WUS.
Factors driving the halophyte rhizosphere bacterial communities in coastal salt marshes
Authors: Wang Rumiao , Cui Lijuan , Li Jing , Li Wei 
Published: February 2023

IntroductionRoot-associated microorganisms promote plant growth and provide protection from stresses. Halophytes are the fundamental components maintaining ecosystem functions of coastal salt marshes; however, it is not clear how their microbiome are structured across large spatial scales. Here, we investigated the rhizosphere bacterial communities of typical coastal halophyte species (Phragmites australis and Suaeda salsa) in temperate and subtropical salt marshes across 1,100 km in eastern China.MethodsThe sampling sites were located from 30.33 to 40.90°N and 119.24 to 121.79°E across east China. A total of 36 plots were investigated in the Liaohe River Estuary, the Yellow River Estuary, Yancheng, and Hangzhou Bay in August 2020. We collected shoot, root, and rhizosphere soil samples. the number of pakchoi leaves, total fresh and dry weight of the seedlings was counted. The soil properties, plant functional traits, the genome sequencing, and metabolomics assay were detected.ResultsThe results showed that soil nutrients (total organic carbon, dissolved organic carbon, total nitrogen, soluble sugars, and organic acids) are high in the temperate marsh, while root exudates (measured by metabolite expressions) are significantly higher in the subtropical marsh. We observed higher bacterial alpha diversity, more complex network structure, and more negative connections in the temperate salt marsh, which suggested intense competition among bacterial groups. Variation partitioning analysis showed that climatic, edaphic, and root exudates had the greatest effects on the bacteria in the salt marsh, especially for abundant and moderate subcommunities. Random forest modeling further confirmed this but showed that plant species had a limited effect.ConclutionsTaken together, the results of this study revealed soil properties (chemical properties) and root exudates (metabolites) had the greatest influence on the bacterial community of salt marsh, especially for abundant and moderate taxa. Our results provided novel insights into the biogeography of halophyte microbiome in coastal wetlands and can be beneficial for policymakers in decision-making on the management of coastal wetlands.
Electrophysiological correlates of distance and direction processing during cognitive map retrieval: A source analysis
Authors: Teixeira De Almeida Mélanie , Seeber Martin , Gschwend Katherina , Maurer Roland , Faulmann Igor , Burra Nicolas 
Published: February 2023

IntroductionThe cognitive map is an internal representation of the environment and allows us to navigate through familiar environments. It preserves the distances and directions between landmarks which help us orient ourselves in our surroundings. The aim of our task was to understand the role played by theta waves in the cognitive map and especially how the cognitive map is recalled and how the manipulation of distances and directions occurs within the cognitive map.MethodIn order to investigate the neural correlates of the cognitive map, we used the Cognitive Map Recall Test, in which 33 participants had to estimate distances and directions between familiar landmarks tailored to their own knowledge. We examined the role of theta waves in the cognitive map, as well as the brain regions that generated them. To that aim, we performed electroencephalographic source imaging while focusing on frequency spectral analysis.ResultsWe observed increases of theta amplitude in the frontal, temporal, parahippocampal gyri and temporal poles during the recall of the cognitive map. We also found increases of theta amplitude in the temporal pole and retrosplenial cortex during manipulation of directions. Overall, direction processing induces higher theta amplitude than distance processing, especially in the temporal lobe, and higher theta amplitude during recall compared to manipulation, except in the retrosplenial cortex where this pattern was reversed.DiscussionWe reveal the role of theta waves as a marker of directional processing in the retrosplenial cortex and the temporal poles during the manipulation of spatial information. Increases in theta waves in frontal, parahippocampal, temporal and temporal pole regions appear to be markers of working memory and cognitive map recall. Therefore, our Cognitive Map Recall Test could be useful for testing directional difficulties in patients. Our work also shows that there are two distinct parts to the cognitive map test: recall and manipulation of spatial information. This is often considered as two similar processes in the literature, but our work demonstrates that these processes could be different, with theta waves from different brain regions contributing to either recall or manipulation; this should be considered in future studies.
The cognitive and behavioral correlates of functional status in patients with frontotemporal dementia: A pilot study
Authors: Chatzidimitriou Electra , Ioannidis Panagiotis , Moraitou Despina , Konstantinopoulou Eleni , Aretouli Eleni 
Published: February 2023

Objective: Frontotemporal dementia (FTD) impinges significantly on cognition, behavior, and everyday functioning. Goal of the present study is the detailed description of behavioral disturbances and functional limitations, as well as the investigation of associations between cognition, behavior, and functional impairment among FTD patients. Given the importance of maintaining a satisfying functional status as long as possible, this study also aims to identify the cognitive correlates of compensatory strategy use in this clinical group.Methods: A total of 13 patients diagnosed with FTD (behavioral variant FTD = 9, non-fluent variant primary progressive aphasia = 3, semantic dementia = 1) were administrated a broad range of neuropsychological tests for the assessment of different cognitive abilities. Behavioral symptomatology and performance on everyday activities were rated with informant-based measures. Descriptive statistics were used for the delineation of behavioral and functional patterns, whereas stepwise multiple regression analyses were performed to identify associations between cognition, behavior, and functional status.Results: Negative symptoms, especially apathy, were found to predominate in the behavior of FTD patients. Instrumental tasks, such as housework and leisure activities, appeared to be the most impaired functional domains. Working memory was the strongest cognitive correlate of performance across various domains of everyday functioning, whereas working memory along with short-term verbal memory accounted for a great proportion of variance in compensatory strategy use. Behavioral disturbances and especially negative symptoms were also found to contribute significantly to functional impairment in FTD.Conclusions: Executive dysfunction, as well as behavioral disturbances contribute significantly to functional disability in FTD. Early interventions tailored at these domains may have the potential to improve functional outcomes and delay the rate of functional decline among FTD patients.