bluuebunny/crossref_metadata_2025_split huggingface dataset:
Punicagranatum as a local drug delivery system: A Clinico microbiological study
Authors: Gupta Shikha , Pandit Aashish , Mathur Setu , Aggarwal Manoj 
Published: July 2023

The use of herbal/ natural compounds can be comparatively safer alternative to those of synthetic compounds for periodontal therapy. The present study aims to investigate the effect of pomegranate extracts in form of chip for treating adult patients affected with periodontitis followed with scaling and root planing. The study was conducted in two parts: Invitro and Invivo. The study was a randomized controlled study and was addressed by clinical and microbiological parameters at base line and subsequent intervals.
Material and methods:In vitro release was performed by using Keshary-chien diffusion cell for randomly selected strip. In vivo30patients with adult periodontitis having initial pocket depth ≥4 mm were enrolled into this research. For each subject two experimental sites were chosen located in symmetrical quadrants. Sites were randomly assigned to control group or test group. Then subgingival application of medicated chips was done in both groups. The clinical parameters were recorded at baseline, 30 days and 90 days. Descriptive statistical analysis has been carried out in present study.
Results: The in vivo study confirmed significant improvements of plaque index ratings with significant reduction in gingival index, plaque index and relative attachment level scores at 90 days as compared to control group. While Porphyromonasgingivalis ,Prevotellaintermedia , Fusobacteriumintermedia and Aggregatibacteractinomycetemcomitans showed a more significant reduction at 90 days as compared to control group. In vitro results showed complete drug release in – 72- 80 hours .Matrix degrades between 3 to 4 days. Pomegranate extracts in chip may provide additional advantages to scaling and root planing for improving periodontal status.
KEYWORDS: Chip, gingiva, periodontal, pomegranate, punicagranatum
A nonsurgical approach in management of burns induced microstomia: a review
Authors: Agrawal Ruchi , Choukse Vivek , Aidasani Ashwin , Gandagule Ranjeet 
Published: July 2023

Burns of head and neck region causes skin contracture which will result in microstomia and loss of skin flaccidity. The prevention and management of microstomia contracture is an important aspect of facial burn. The goal of microstomia repair include the reconstruction of orbicularis sphincter for adequate lip functioning, obtaining lip symmetry and well positioned scar and adequate mouth opening. The standard treatment for the prevention and management of contracture includes compression therapy, grafting, mouth splinting, scar massage, excercise, patient education. These types of maxillofacial prosthetic appliances may be indicated, in conjunction with or without surgery these appliances can be use to improve the reduced mouth opening caused by burns or other traumatic injuries With proper education and motivation of operator and the patient use of these appliances will not only improve the reduced mouth opening but also improve form, function, esthetics, and also enhance the patient’s quality of life.
Free Fibula Flap in Mandibular Reconstruction : A Case Report
Authors: Yadav Shiwangi 
Published: July 2023

The reconstruction of the mandible is a complex procedure and continues to be a challenge in reconstructive maxillofacial surgery. Indications for mandibular reconstruction are varied and include pathological resections, traumatic injuries and residual deformities amongst others. The mandible is an important anatomical unit of maxillofacial skeleton in terms of both aesthetics and function which necessitates its immediate reconstruction after resection.
A 16 years old female patient, diagnosed with ameloblastoma of left hemi -mandible underwent resection with immediate reconstruction using free fibula flap. Twenty two months follow up reveals excellent bony union and facial contours. The objective of the treatment is to resecting the mandibular defects and reconstruction with free fibular flap.
Our experience combined with positive literature references enhances the reliability of free fibular vascularized graft as a suitable and versatile reconstructive option for complex anatomical contours of the mandible.
The Comparison of the effect of two different doses of methylprednisolone on pain, swelling and trismus after 3rd molar surgery.
Authors: GARG KAMAL 
Published: July 2023

Objective The aim of this study was to compare the effects of intravenous administration of 1.5mg/kg and 3mg/kg of methylprednisolone sodium succinate on pain, swelling and trismus after third molar surgery.
Study Design. Twenty five healthy patients with bilaterally symmetrical impacted mandibular third molars were included in this study. Either 1.5mg/kg or 3mg/kg of methylprednisolone was administered by intravenous route 1 hour before the operation. At the second operation the other dose was applied. Facial swelling was evaluated by using cotton sutures. Trismus was determined by measuring maximum interincisal opening. Pain was determined by using visual analogue scale.
Results. There was no statistically significant difference in pain swelling and trismus between the two groups.
Conclusion. No significant benefit of higher dose of methylprednisolone administered.
Analysis of a three-dimensional numerical modeling approach for predicting scour processes in longitudinal walls of granular bedding rivers
Authors: Calixto Nelson Cely , Zambrano Melquisedec Cortés , Castaño Alberto Galvis , Soto Gustavo Carrillo 
Published: July 2023

In rivers, longitudinal walls are protective structures that are directly supported on the riverbank are frequently used as hydraulic prevent the current from eroding the bank and causing scouring. However, these structures have the potential to block flow and produce erosive processes that progressively worsen scour in their area, leading to faulting and other problems. The current study used Flow-3D software to understand the scour process at the base of longitudinal walls in rivers with a well-graded granular bed. Experimental data from a physical model replicating a river with a longitudinal wall and a well-graded granular bed were used to validate the model. The investigation examined the average flow velocity and its effects on scour behavior along the longitudinal wall using the Flow-3D program. The findings showed that the Flow-3D model could improve the evaluation of debugging processes, because it provided a useful answer that closely matched the experimental data derived from the physical model. Validation with a 0.07 m mesh demonstrated that the Flow-3D model could faithfully simulate the scour process along the longitudinal wall. Overall, the findings of this study suggest that the Flow-3D software can be a useful tool for predicting the scouring process in rivers with well-graded granular beds and longitudinal walls. This is particularly important for engineers and researchers who are interested in designing and optimizing hydraulic structures to mitigate the effects of scouring, because it provided a useful answer that closely matched the experimental data derived from the physical model
A multi-criteria decision-making in relieving grinding process of surface of gear milling tooth based on the archimedean spiral using taguchi-ahp-topsis method
Authors: Nguyen Kien Huy , Pham Dong Van , Tran Quoc Ve 
Published: July 2023

In this study, in order to optimize the quality criteria of the machined surface based on the Archimedean spiral, the relieving grinding process (RGP) was performed to machine the material of HSS P18 in a 1Б811 machine with four input parameters including graininess of grinding wheel (G), grinding wheel hardness (Hd), velocity of grinding wheel (V), and feed rate (s) and with three quality criteria including surface roughness (Ra), hardening of surface layer (∆HRC), and hardened layer thickness (∆L). Taguchi-AHP-Topsis method was successfully applied to solve the Multi-Criteria Decision Making (MCDM) problem in this case. The optimized results of the output parameters are surface roughness of 0.21 µm, surface hardening of 1.45 HRC, and hardened layer thickness of 34.18 µm. These results were determined at the set of the input parameters includes G, V, s with their values of 120, 24 m/s, 2.08 m/min, respectively, and Hd at level 1. The optimal results were verified through the comparison between the calculated and the experimental results using this set of optimal parameters. The differences between the calculated results and the experimental results were quite small (maximum different value was 4.8 %) Thus, the results of this study can be applied to solve the multi-objective optimization problems in RGP of the GMT surface based on the Archimedean spiral
Development of a calculation scheme for selecting the optimal mode of operation of a gas condensate well taking into account the deformation conditions of the formation
Authors: Abbasova Samira , Mammadova Gulbahar 
Published: July 2023

To establish premature optimal well operation modes, it is necessary to consider the process of well operation within the framework of ongoing processes in the common reservoir-well hydrodynamic system and take into account the peculiarities of changes in the properties of the gas condensate mixture and the thermobaric conditions of the reservoir in it. Therefore, the object of the study is the operation of a gas condensate well in the event of technological complications in it, which requires the selection of the necessary optimal operating mode to prevent these complications by comprehensively taking into account the factors influencing this process in the “reservoir-well” system.
The article proposes a calculation scheme for establishing the optimal operating mode of a gas condensate well without the formation of a liquid plug at the bottomhole, taking into account the formation deformation during field development in the depletion mode. The problem is solved by determining the required current working volume of produced gas (as well as condensate), bottomhole and contour values of reservoir pressure, condensate saturation and reservoir porosity. As a result of the study, it was revealed that the determined characteristics of the selected optimal mode of a gas condensate well are significantly affected by a change in the reservoir properties of the reservoir (for example, the permeability of the reservoir), which in turn leads to a change in the optimal working gas flow rate of the well.
The considered problem has not been previously studied in its full formulation, which is presented in this article, where the solution of the problem under study is achieved taking into account the change in the physical properties of the reservoir fluid and gas, as well as the reservoir properties of the reservoir under conditions of a change in the state of the reservoir system due to emerging deformation processes in the reservoir
Development of a new technology for the fight against wax deposits
Authors: Gurbanov Abdulaga , Sardarova Ijabika , Damirova Javida , Mahmudova Zarifa 
Published: July 2023

One of the most serious complications in the production, transport and treatment of oil is asphaltene-resin-paraffin deposits. Their formation in underground well equipment, as well as in flow lines, collection system pipelines increase the cost of oil production. There are no sufficiently effective reagents to solve these problems. The results of implementation in many other wells testify to the high efficiency of the new reagent. The effect of reagents on the rheological properties of oil was also studied. Sangachal Deniz oil was used as a crude oil sample. We have developed multicomponent and multifunctional reagents M-R, P-R. In addition, due to paraffin formations in the tubing, they had to change 50–60 pipes for new ones every month. As a result of the introduction of M-R reagents, no paraffin deposits were found in the tubing for almost a year The effect of these reagents on the pour point of oils, dispersion, dissolution, and paraffin deposition has been studied. The use of the new reagent was tested at the mines of the oil and gas production department (OGPD) "28 May". The results of implementation in many other wells testify to the high efficiency of the new reagent. The effect of reagents on the rheological properties of oil was also studied. Sangachal Deniz oil was used as a crude oil sample.
The proposed three-parameter Herschel-Bulkley model can be used to assess the rheological parameters of oils during their transportation. This layer, of course, cannot thicken indefinitely. Highly effective multicomponent composite compositions were developed to combat complications in the production of high-asphaltene-resin-paraffin oils. As can be seen from, during the reagent dosing period, there were no particular changes in the well performance. Treatment with hot oil on certain days was, as it were, of a preventive nature, since no changes were observed in the well parameters before and after heat treatment. When a certain layer thickness is formed in the tubing, the linear velocity of oil increases and begins to wash it away
Clinical efficacy and antioxidant properties of interferon inducers in the treatment of acute respiratory diseases in children
Authors: Vakhitov Kh. M. , Mamleev R. N. , Vakhitova L. F. 
Published: July 2023

Introduction. Diagnosis, treatment and prevention of respiratory infections in the practice of a pediatrician occupy one of the leading places. Currently, much attention is paid to various links in the pathogenesis of viral respiratory diseases. Among them, particular importance is attached to the system of antioxidant defense and cytokine regulation of inflammation. It is important to study the effect of various drugs on these links of pathogenesis in order to increase the clinical effectiveness of therapeutic methods.Aim. To evaluate the clinical efficacy and impact on lipid peroxidation of Kagocel® in the treatment of respiratory viral infections in children.Materials and methods. An observational study was conducted involving 124 children aged 6 to 15 years with manifestations of a respiratory viral infection who received symptomatic treatment, of which 89 children additionally took antiviral therapy with Kagocel®.Results. Along with the good tolerance of Kagocel® and the absence of side effects in children on the background of its use, a significantly shorter period of regression of the main clinical symptoms of acute respiratory infection was shown. It was noted that in children taking Kagocel® on the 3rd-5th day of therapy, there is an increase in the total antioxidant activity of blood plasma and a decrease in the level of malondialdehyde compared with patients who did not take the drug, which demonstrates the antioxidant effects of Kagocel®, which certainly have a positive effect on the character course of the healing process.Conclusion. Kagocel® has been shown to have high clinical efficacy and antioxidant effects.
Features of processor fitting in patients with different types of cochlear implant electrode array
Authors: Pashkova A. Е. , Popadyuk V. I. , Voevodina K. I. , Naumova I. V. , Kirichenko I. M. , Pashkov A. V. 
Published: July 2023

Introduction. The results of cochlear implantation in patients with bilateral sensorineural hearing loss are influenced by many factors, including the type of electrode array. The location of the electrodes in relation to neurons of spiral ganglion affects on levels of perception of the patient's hearing sensations.Aim. To evaluate the dependence of electrically evoked compound action potential (ECAP) thresholds values and comfortable levels depends on electrode array type.Materials and methods. 26 patients with bilateral sensorineural hearing loss with cochlear implantation systems were examined. The patients were divided into 2 groups: 1) patients with a straight electrode array (n = 14); 2) patients with a perimodiolar electrode array (n = 12). We tested speech intelligibility and ECAP thresholds. The difference in the values of both parameters was estimated.Results. For both groups of patients, the relationship between the threshold's profiles of ECAP thresholds and maximum comfortable stimulation levels was detected. For patients from the first group (straight electrode array), the differences in values between the studied parameters were 30.6 ± 6.1%. In patients from the second group, the differences in the values of the thresholds for ECAP thresholds and the levels of comfortable stimulation ranged 2.4 ± 2.1%.Conclusion. The perimodiolar electrode array is located closer to the neurons of the spiral ganglion, which may explain the greater relationship between the values of the ECAP thresholds and the levels of comfortable stimulation. This pattern must be considered when programming the processor of the cochlear implantation system.
Microbiological justification of the advisability of using essential oils of medicinal plants in the treatment of inflammatory diseases of the upper respiratory tract
Authors: Ivanova E. V. , Danilova E. I. , Chainikova I. N. , Chelpachenko O. E. , Fadeev S. B. , Bondarenko T. A. , Bekpergenova A. V. 
Published: July 2023

Introduction. The role of the respiratory tract microflora violations as an etiological and pathogenetic factor in the development of the inflammative upper respiratory tract disease is indisputable, and the importance of persistence factors of respiratory opportunistic microorganisms (URT) is high. The traditional use of antibiotics and antimycotic agents in the pathology of URT has failed due to a significant increase in the number of antibiotic-resistant strains of microorganisms and the development of a number of undesirable adverse reactions in patients. An alternative advantage in these conditions is belonged to herbal preparations.Aim. To conduct a comparative in vitro study of antibacterial and antifungal activities of the plant essential oils as a component of the Dyshi Oil composition and the Dyshi Oil composition itself against opportunistic microorganisms - causative agents of inflammatory upper airway diseases.Materials and methods. Essential oils of clove, juniper, peppermint, eucalyptus, as well as the composition of oils “Dyshi” were used in the work. Staphylococcus aureus ATCC 25923, Klebsiella pneumoniae ICIS-278, Pseudomonas aeruginosa ATCC 27853, and Candida albicans ATCC 24433 bacterial cultures were used as test cultures. Staphylococcus epidermidis 25 strain, isolated from a conditionally healthy person, was chosen as a representative of the URT normobiota. Antimicrobial activity of essential oils was determined by the method of diffusion in nutrient agar, MIC - by the method of serial dilutions.Results. The presence of zones of pronounced growth retardation of Staphylococcus aureus, Klebsiella and Pseudomonas, as well as yeast-like fungi was established when exposed to the composition of “Dyshi” oils, while separately used oils did not have a visible effect on the growth of bacteria and fungi, which indicates a synergistic interaction of the drug oils components.Conclusion. The presence of a synergistic antimicrobial effect of the “Dyshi” oil composition against opportunistic bacteria and yeast-like fungi of the genus Candida has been proven. The absence of an inhibitory effect on the growth of Staphylococcus epidermidis, which is a representative of the upper respiratory tract normobiota indicates a possible selective effect of “Dyshi” oil aimed at maintaining the colonization resistance of the URT biotope.
Relationship between vitamin D sufficiency and interferon-γ levels in children with chronic lung diseases
Authors: Dolbnya S. V. , Dyatlova A. A. , Klimov L. Ya. , Kondratyeva E. I. , Zakharova I. N. , Enina E. A. 
Published: July 2023

Introduction. The role and mechanism of the effect of vitamin D on the course of chronic lung diseases in children are not yet fully understood. In particular, there are not enough studies on the effect of vitamin D status on the production of interferon-γ (IFN-γ) in children with cystic fibrosis and bronchial asthma.Aim. To analyse the changes in IFN-γ levels in children with cystic fibrosis and bronchial asthma according to the serum 25(OH)D level before and during cholecalciferol supplementation.Materials and methods. A total of 114 children (aged from 3 months to 18 years old) were examined, including 51 (44.7%) children with bronchial asthma, 34 (29.8%) children with cystic fibrosis, and 29 (25.5%) children of the control group. If hypovitaminosis D was diagnosed, the children received a three-month cholecalciferol course at doses in accordance with the recommendations of the national consensus - Cystic Fibrosis: Definition, Diagnostic Criteria, Therapy and the national program - Vitamin D Deficiency in Children and Adolescents of the Russian Federation: Current Approaches to Management. The 25(OH)D and IFN-γ levels were twice determined in all children.Results. Median 25(OH)D levels in patients with cystic fibrosis and bronchial asthma did not reach the level of healthy children either before or after supplementation with cholecalciferol drugs at the recommended doses. Vitamin D intake resulted in a decrease in IFN-γ levels in healthy children from 3.07 [2.29; 4.81] pg/ml to 2.18 [1.74; 3.45] pg/ml (p < 0.05), whereas such changes were not detected in the paediatric patients with cystic fibrosis and bronchial asthma in the general population. However, after supplementation with cholecalciferol, the IFN-γ level was significantly higher in patients with cystic fibrosis and bronchial asthma - 2.86 [2.13; 3.86] pg/ml and 3.11 [0.89; 5.0] pg/ml, respectively, than in healthy children - 2.18 [1.74; 3.45] pg/ml (p < 0.05). A statistically significant decrease in IFN-γ level was observed in girls with cystic fibrosis and in healthy girls after supplementation with cholecalciferol, whereas no significant changes in IFN-γ levels were detected in the groups of boys.Conclusion. Modulation of IFN-γ levels appears to be one of the mechanisms of immunotropic effect of vitamin D on the course of chronic inflammation of infectious (cystic fibrosis) and allergic (bronchial asthma) etiology in children.
Development of statistical downscaling methods for the assessment of rainfall characteristics under climate change scenarios
Authors: Onarun Thanipa , Thepprasit Chaiyapong , Sittichok Ketvara 
Published: July 2023

Abstract

The objective of this research was to develop a statistical downscaling approach in the Phetchaburi River Basin, Thailand, consisting of two main processes: predictor selection and relationship construction between predictors and local rainfall. Super predictor (SP) and stepwise regression (SR) were employed with principal component analysis (PCA) and the statistical downscaling model (SDSM) was applied later. Four statistical models were finally used: M1 (SP–PCA), M2 (SP–SDSM), M3 (SR–PCA), and M4 (SR–SDSM) with 26 large circulation indices generated by CanESM2 (CMIP5). Finally, the characteristics of extreme rainfall events were observed under three climate change scenarios during three different periods (2020–2040, 2041–2070, and 2071–2100). The results revealed that rainfall and geostrophic airflow velocity were the best predictors for rainfall downscaling, followed by divergence, meridional velocity, and relative humidity. Three objective functions (R2, NSE, and RMSE) were applied to evaluate model performance. The M4 model presented the highest performance while M1 showed the lowest skill. The average annual rainfall specifically increased compared with the historical rainfall for RCP2.6, RCP4.5, and RCP8.5 scenarios in future periods. Very to extremely wet years determined by the standardized anomaly index (SAI) occurred more often in the far-future while severe to extremely dry years frequently occurred in the mid- and far-future.