bluuebunny/crossref_metadata_2025_split huggingface dataset:
The World Health Organization classification of pancreaticobiliary cytopathology stratifies risk of malignancy and outcome for endoscopic ultrasound‐guided fine‐needle aspiration of the pancreas
Authors: Lui Shu Kwun , Hargett Imani , Pharaa Zaynab , Aviles Mariela , Botelho Stephany , Feliciano Dominique L. , Kim Veronica , Sigel Keith , Armstrong Misha , Wilson Christina E. , Shah Pari , Soares Kevin , Sigel Carlie 
Published: August 2023

AbstractBackgroundThe World Health Organization (WHO) has recently published a classification for reporting pancreaticobiliary cytopathology with differences compared to the Papanicolaou Society of Cytopathology (PSC) classification.MethodsRetrospective data were collected from pancreatic endoscopic ultrasound‐guided fine‐needle aspirations from 2014 to 2017 at a pancreatic cancer center. Absolute risk of malignancy (AROM), relative risk (to benign), performance characteristics, and overall survival were calculated for the entire cohort with comparison of cysts and solid lesions.ResultsIn total, 2562 cases were included: 16% cyst (n = 411) and 84% solid (n = 2151). The histologic confirmation rate was 43% (n = 1101) and the median follow‐up (for benign) was 56 months. For WHO I–VII, overall AROM (%) was 23, 22, 62, 13, 65, 97, and 100; cyst AROM was 7, 0, 19, 13, 38, 78, and 100; and solid AROM was 50, 29, 70, 15, 100, 99, and 100. For PSC I–VI, overall AROM (%) was 23, 29, 64, 0 (IVa), 60 (IVb), 97, and 100; cyst AROM was 7, 0, 19, 0, 21, 78, and 100; and solid AROM was 50, 35, 73, 0, 92, 99, and 100. The difference in relative risk for a cyst (vs. solid) overall was 0.38 for WHO and 0.26 for PSC. WHO and PSC categories showed stratification for the probability of overall survival.ConclusionsCystic versus solid lesion type can dramatically affect AROM, particularly for nondiagnostic (I), benign (II), atypical (III), and WHO V categories. WHO IV conveys a similarly low AROM for cystic and solid types. Both classifications stratify the probability of overall survival, including the newly introduced categories WHO IV and WHO V.
The uterine adenosarcoma with postoperative residual in a woman treated by total abdominal hysterectomy/bilateral salpingo‐oophorectomy: A case report and review of literature
Authors: Fadavi Pedram , Garousi Maryam , Soltani Sepideh , Montazer Fatemeh , Abolhasani Maryam , Asgari Salar , Mirzaee Elahe 
Published: August 2023

AbstractBackgroundIn patients with uterine adenosarcoma, a total abdominal hysterectomy (TAH) with bilateral salpingo‐oophorectomy (BSO) is typically recommended as an initial treatment. There is no consensus on adjuvant therapies.CaseWe report the case of a patient with uterine adenosarcoma with postoperative residual disease. We performed four courses of adjuvant chemotherapy, including Ifosfamide, Mesna, and Adriamycin, and whole pelvic radiation with a dose of 50.4 Gy/28 Fr.ConclusionA combination of chemotherapy and radiotherapy may be a promising treatment option for uterine adenosarcoma with postoperative residual disease.
Competitive performance as a discriminator of doping status in elite athletes
Authors: Hopker James G. , Griffin Jim E. , Hinoveanu Laurentiu C. , Saugy Jonas , Faiss Raphael 
Published: August 2023

AbstractAs the aim of any doping regime is to improve sporting performance, it has been suggested that analysis of athlete competitive results might be informative in identifying those at greater risk of doping. This research study aimed to investigate the utility of a statistical performance model to discriminate between athletes who have a previous anti‐doping rule violation (ADRV) and those who do not. We analysed performances of male and female 100 and 800 m runners obtained from the World Athletics database using a Bayesian spline model. Measures of unusual improvement in performance were quantified by comparing the yearly change in athlete's performance (delta excess performance) to quantiles of performance in their age‐matched peers from the database population. The discriminative ability of these measures was investigated using the area under the ROC curve (AUC) with the 55%, 75% and 90% quantiles of the population performance. The highest AUC values across age were identified for the model with a 75% quantile (AUC = 0.78–0.80). The results of this study demonstrate that delta excess performance was able to discriminate between athletes with and without ADRVs and therefore could be used to assist in the risk stratification of athletes for anti‐doping purposes.
Value recovery from waste in the processing of buckwheat: Opportunities for a circular bioeconomy
Authors: Gonçalves Mary Ane Aparecida , Salvador Rodrigo , de Francisco Antonio Carlos , Piekarski Cassiano Moro 
Published: August 2023

AbstractIn the processing of buckwheat to produce flour, wastes account for approximately 20% of the whole grain. This article points out the potential routes for value recovery of the waste obtained in the processing of buckwheat during the production of flour, thus fomenting a circular bioeconomy. To that end, the following steps were taken: (a) characterizing the processing of buckwheat for flour production and the wastes generated; (b) listing existing actions for different uses of the wastes obtained in the processing of buckwheat; (c) categorizing the uses of buckwheat wastes according to the existing literature; and (d) classifying the potential uses of the wastes obtained in the processing of buckwheat within the categories identified. Buckwheat wastes can be used to produce goods in the sectors of fertilizers; food; chemical; pharmaceutical; fabrics, yarns, and threads; cements and asbestos; hygiene and personal products; and other products. Food (human and animal) products presented the greatest market attractiveness, followed by pharmaceutical products. However, potential for innovation considering the sectors' revenue point out that food and chemical products are the most promising. This study provides guidance on how to use innovation to guide opportunities for a more circular bioeconomy toward both environmental and economic benefits.
Pistacia lentiscus L. vegetable oil: Physicochemical quality, composition and antibacterial capacity
Authors: Djebari Sabrina , Wrona Magdalena , Boudria Asma , Madani Khodir , Nerin Cristina 
Published: August 2023

AbstractRecently, there has been a growing interest in natural products of plant origin as herbal remedies. In this study, the profile of bioactive volatile organic compounds and odorous compounds in a sample of Pistacia lentiscus L. vegetable oil has been determined. The study indicated that the oil extraction yield is influenced by the method, the extraction conditions, the stage of maturity of plant and the sampling area. Analysis by HS‐SPME‐GC–MS and GC–MS showed that monoterpenes and sesquiterpenes represent the most numerous groups among the 57 compounds identified. The most abundant compounds are beta‐myrcene, d‐limonene and linoleic acid ethyl ester. Among other compounds humulene, caryophyllene, a‐muurolene and copaene have been detected known for facilitating wound healing. Moreover, β‐caryophyllene and α‐humulene with anti‐inflammatory effects have been determined. 38 different odorous compounds with herbal, citrus and vegetable aromas were detected by panellists using HS‐SPME‐GC‐O‐MS. Research confirmed that the analysed samples have only pleasant aromas that make it a perfect active agent for medicinal use and may gain acceptance of consumers.
LSF films formed on YSZ electrolytes via polymeric precursor deposition for solid oxide fuel cell anode applications
Authors: Bilbey Buse , Asghar M. Imran , Arslan Leyla Colakerol , Lund Peter D. , Büyükaksoy Aligul 
Published: August 2023

AbstractDifferent materials have been applied as anode in solid oxide fuel cell (SOFC). Perovskite structured materials are promising as an alternative electrode material to Ni. Here, we investigated perovskite‐structured mixed ionic and electronic conducting material, lanthanum strontium ferrite (LSF), which has typically been used as a cathode material. LSF has also shown potential for an anode in SOFC. LSF films with two different compositions, La0.6Sr0.4FeO3 (6LSF) and La0.8Sr0.2FeO3 (8LSF) were fabricated by a polymeric precursor method. The effects of the phase content, surface chemistry, and microstructure on the anode performance were investigated. It was found that a mixture of the Ruddlesden–Popper phase, SrCO3 phases, and rhombohedral perovskite exists in both cell structures. Both cells had Ruddlesden–Popper and SrCO3 phases at their surface, in addition to the rhombohedral perovskite. Symmetrical half‐cell measurements showed that the polarization resistance of 6LSF (0.34 Ω cm2) is lower than that of 8LSF (0.47 Ω cm2), mostly because of its highly porous microstructure as a result of slower A‐site diffusion rates induced by higher Sr content.The symmetrical 6LSF fuel and air electrodes exhibited ASRelectrode values of 0.34 and 0.14 Ω cm2, respectively, at 800 ˚C.
Computed Tomography Provides Improved Quantification of Trabecular Lumbar Spine Bone Loss Compared to Dual‐Energy X‐Ray Absorptiometry in Ovariectomized Sheep
Authors: Bisazza Katie T , Nelson Brad B , Sikes Katie J , Nakamura Lucas , Easley Jeremiah T 
Published: August 2023

ABSTRACTEarly detection of osteoporosis using advanced imaging is imperative to the successful treatment and prevention of high morbidity fractures in aging patients. In this preclinical study, we aimed to compare dual‐energy X‐ray absorptiometry (DXA) and quantitative computed tomography (QCT) to quantify bone mineral density (BMD) changes in the sheep lumbar spine. We also aimed to determine the relationship of BMD to microarchitecture in the same animals as an estimate of imaging modality precision. Osteoporosis was induced in 10 ewes via laparoscopic ovariectomy and administration of high‐dose corticosteroids. We performed DXA and QCT imaging to measure areal BMD (aBMD) and trabecular volumetric BMD (Tb.vBMD)/cortical vBMD (Ct.vBMD), respectively, at baseline (before ovariectomy) and at 3, 6, 9, and 12 months after ovariectomy. Iliac crest bone biopsies were collected at each time point for micro‐computed tomography (microCT) analysis; bone volume fraction (BV/TV), trabecular number (Tb.N), thickness (Tb.Th), and spacing (Tb.Sp) were reported. aBMD and Tb.vBMD both decreased significantly by 3 and 6 months (p < 0.05) compared with baseline, whereas no changes to Ct.vBMD were observed. Combined (Tb. and Ct.) vBMD was significantly correlated with aBMD at all time points (all p < 0.05). Additionally, greater significant correlations were found between BV/TV and Tb.vBMD at all five time points (R2 = 0.54, 0.57, 0.66, 0.46, and 0.56, respectively) than with aBMD values (R2 = 0.23, 0.55, 0.41, 0.20, and 0.19, respectively). The higher correlation of microCT values with QCT than with DXA indicates that QCT provides additional detailed information regarding bone mineral density changes in preclinical settings. Because trabecular bone is susceptible to rapid density loss and structural changes during osteoporosis, QCT can capture these subtle changes more precisely than DXA in a large animal preclinical model. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
On the directed Oberwolfach problem for complete symmetric equipartite digraphs and uniform‐length cycles
Authors: Francetić Nevena , Šajna Mateja 
Published: August 2023

AbstractWe examine the necessary and sufficient conditions for a complete symmetric equipartite digraph with parts of size to admit a resolvable decomposition into directed cycles of length . We show that the obvious necessary conditions are sufficient for in each of the following four cases: (i) is even; (ii) ; (iii) and or ; and (iv) , and if , then for a prime .
Exposure therapy for health anxiety: Effectiveness and response rates in routine care of an outpatient clinic
Authors: Roth‐Rawald Julia , Maaß Ulrike , Mai Stefanie , Weck Florian 
Published: August 2023

AbstractObjectiveMany randomized controlled trials (RCTs) have demonstrated the efficacy and benefits of exposure therapy in the treatment of health anxiety. However, the application of these research results to routine care has not been considered sufficiently. The aim of this study is to analyze the effectiveness of exposure therapy in the routine treatment of health anxiety patients.MethodData were available for 35 patients, who repeatedly filled in comprehensive general questionnaires, and those specific to health anxiety.ResultsThe data analysis showed that health anxiety symptoms decreased significantly both posttreatment (Cohen's d = 0.97–1.00) and at follow‐up (Cohen's d = 1.33–1.34). In addition, the scores of depressiveness, somatic symptoms, and psychological distress showed improvements with effect sizes of d = 0.35–0.51. Regarding the primary outcome measures for health anxiety, response rates were 51%–63%, and remission rates were 29%–43%.ConclusionExposure therapy is effective and sustainable regarding the treatment of health anxiety, even under naturalistic conditions, whereas response and remission rates are lower than for RCT.
Uncovering the relationship between community participation and socio‐political control among the migrant population
Authors: Martinez‐Damia Sara , Paloma Virginia , Luesia Juan Fernando , Marta Elena , Marzana Daniela 
Published: August 2023

AbstractPrior research on psychological empowerment has found that community participation is associated with socio‐political control, which takes place when people perceive control in their socio‐political contexts. However, the process by which this relationship occurs remains an understudied area for migrants. This study aims to: (a) analyze the differences in socio‐political control, critical thinking, and ethnic identity according to membership in migrant community‐based organizations; and (b) propose a predictive model of socio‐political control. A total of 239 first‐generation migrants living in northern Italy completed a questionnaire (48.4% belonged to a migrant community‐based organization). Members were found to have higher levels than nonmembers in all the variables. A moderated mediation model was proposed, whereby ethnic identity was a mediator between community participation and socio‐political control, and critical thinking was a negative moderator between ethnic identity and socio‐political control. Practical implications for enhancing socio‐political control among migrants in receiving societies are discussed.
Prenatal diagnosis of closed gastroschisis: What to expect in the most severe form of gastroschisis? Case report and literature review
Authors: Castro Pedro Teixeira , Matos Ana Paula Pinho , Macedo Nicanor , Ribeiro Gerson , Lopes Jorge , Dittmer Fernanda Parciasepe , Araujo Júnior Edward , Werner Heron 
Published: August 2023

AbstractClosed gastroschisis (CG) and vanishing gastroschisis (VG) are the most severe forms of evolution of the malformation. In this case, a fetus presented with gastroschisis at 13 weeks, and the gastroschisis was not visualized at 22 weeks of gestation. Distal ileum, cecum, and ascending colon atresia were diagnosed at surgery, and the child is fully enteral‐fed at 5 months of age. In a literature review of 43 cases of prenatal diagnosis of CS‐VG, intrauterine death occurred in 4.5% of cases. 79.6% of the cases underwent surgical treatment. Of these cases, 20% of cases died due to complications of treatment, 26% were still under treatment and 54% are alive with enteral feeding. In 77% of the cases, the closure of the umbilical ring occurred after 26 weeks of gestation and the absence of prenatal diagnosis of CG‐VG during pregnancy has a risk of 71% of death.
ApoE expression in macrophages communicates immunometabolic signaling that controls hyperlipidemia‐driven hematopoiesis & inflammation via extracellular vesicles
Authors: Phu Tuan Anh , Ng Martin , Vu Ngan K. , Gao Alex S. , Raffai Robert L. 
Published: August 2023

AbstractWhile apolipoprotein E (apoE) expression by myeloid cells is recognized to control inflammation, whether such benefits can be communicated via extracellular vesicles is not known. Through the study of extracellular vesicles produced by macrophages derived from the bone marrow of Wildtype (WT‐BMDM‐EV) and ApoE deficient (EKO‐BMDM‐EV) mice, we uncovered a critical role for apoE expression in regulating their cell signaling properties. WT‐BMDM‐EV communicated anti‐inflammatory properties to recipient myeloid cells by increasing cellular levels of apoE and miR‐146a‐5p, that reduced NF‐κB signalling. They also downregulated cellular levels of miR‐142a‐3p, resulting in increased levels of its target carnitine palmitoyl transferase 1A (CPT1A) which improved fatty acid oxidation (FAO) and oxidative phosphorylation (OxPHOS) in recipient cells. Such favorable metabolic polarization enhanced cell‐surface MerTK levels and the phagocytic uptake of apoptotic cells. In contrast, EKO‐BMDM‐EV exerted opposite effects by reducing cellular levels of apoE and miR‐146a‐5p, which increased NF‐κB−driven GLUT1‐mediated glucose uptake, aerobic glycolysis, and oxidative stress. Furthermore, EKO‐BMDM‐EV increased cellular miR‐142a‐3p levels, which reduced CPT1A levels and impaired FAO and OxPHOS in recipient myeloid cells. When cultured with naïve CD4+ T lymphocytes, EKO‐BMDM‐EV drove their activation and proliferation, and fostered their transition to a Th1 phenotype. While infusions of WT‐BMDM‐EV into hyperlipidemic mice resolved inflammation, infusions of EKO‐BMDM‐EV increased hematopoiesis and drove inflammatory responses in myeloid cells and T lymphocytes. ApoE‐dependent immunometabolic signaling by macrophage extracellular vesicles was dependent on transcriptional axes controlled by miR‐146a‐5p and miR‐142a‐3p that could be reproduced by infusing miR‐146a mimics & miR‐142a antagonists into hyperlipidemic apoE‐deficient mice. Together, our findings unveil a novel property for apoE expression in macrophages that modulates the immunometabolic regulatory properties of their secreted extracellular vesicles.
Substrate‐controlled chemoselective synthesis of 1‐sulfonylquinazoline‐2,4(1H,3H)‐diones and 2‐sulfonamidobenzonitriles
Authors: Zhao Ping , Zeng Qingle 
Published: August 2023

AbstractWe have developed a diversity‐oriented, substrate‐controlled, chemoselective synthetic method for a variety of structurally diverse 1‐sulfonylquinazoline‐2,4(1H,3H)‐diones and 2‐sulfonamidobenzonitriles. This substrate‐controlled synthesis is accomplished through the condensation reaction of 2‐(sulfonamido)benzamides with or without an N‐methyl group on the amides. The reactions are fulfilled within half an hour at room temperature with solid triphosgene as a convenient condensing agent and pyridine as an acid acceptor. This protocol features easily available starting materials, mild reaction conditions, easy experimental operation, and moderate to excellent yields of products.
Why foreign agricultural investment fails? Five lessons from Ethiopia
Authors: Cochrane Logan , Li Eric P. H. , Dejene Melisew , Husain M. Mustahid 
Published: August 2023

AbstractIn the past two decades, foreign direct investment (FDI) in emerging economies has witnessed substantial growth in the agricultural sector. Globally, more than a quarter of these investments have failed. Beyond case studies, the factors that contribute to these failures have been subject to limited research. To address this research gap, this article draws on a unique data set of 106 investments in Ethiopia, from which failures were identified and detailed case studies analysed to identify the causes of failure. Drawing on the literature on institutional voids, our analysis shows that the high rates of failure in the agricultural sector are often caused by insufficient planning at the proposal stage, assumptions about the availability of expertise, socio‐political and environmental risks, insufficient financing and/or a changing investment landscape and underestimation and/or misunderstanding regarding the limits of extractive approaches. These lessons suggest that while FDI in the agricultural sector has potential, the working approaches require significant transformation. We offer a set of strategic recommendations to mitigate the risk of investment failure in agricultural investment.
MRA for Preoperative Planning and Postoperative Management of Perforator Flap Surgeries: A Review
Authors: Thimmappa Nanda Deepa 
Published: August 2023

Perforator flap magnetic resonance angiography (MRA) has emerged as a widely accepted and preferred modality for perforator flap mapping at several institutions. Autologous perforator flaps are a type of reconstructive microsurgical technique that involves transferring skin and fat from one part of the patient's body to another to replace tissue lost due to trauma, cancer resection, or other reasons. Autologous perforator flaps are based on a specific perforating blood vessel perfusing the transferred tissue. Hence, the surgery relies on the precise identification and mapping of perforating vessels to ensure successful outcomes. With its superior soft tissue contrast and multiplanar imaging capabilities, MRA has shown great potential in providing accurate and detailed visualization of perforator anatomy, size, and course. This review article summarizes the current literature on perforator flap MRA, including its technical considerations, imaging protocols, postprocessing, and reporting, specifically for autologous breast reconstructions. The advantages and limitations of MRA in evaluating perforator flaps are discussed, including its role in preoperative planning, intraoperative guidance, and postoperative assessment. Anatomy, brief surgical technique, specific technical modifications, and reporting of most commonly performed autologous breast flaps are described. Recent advancements in Perforator flap surgery and MRA techniques are discussed. Additionally, we examine the emerging role of artificial intelligence and machine learning in improving the accuracy and efficiency of perforator flap MRA interpretation.Level of Evidence5Technical EfficacyStage 5
Corticotropin‐releasing factor signaling and its potential role in the prefrontal cortex‐dependent regulation of anxiety
Authors: Yang Xin , Geng Fei 
Published: August 2023

AbstractA large body of literature has highlighted the significance of the corticotropin‐releasing factor (CRF) system in the regulation of neuropsychiatric diseases. Anxiety disorders are among the most common neuropsychiatric disorders. An increasing number of studies have demonstrated that the CRF family mediates and regulates the development and maintenance of anxiety. Thus, the CRF family is considered to be a potential target for the treatment of anxiety disorders. The prefrontal cortex (PFC) plays a role in the occurrence and development of anxiety, and both CRF and CRF‐R1 are widely expressed in the PFC. This paper begins by reviewing CRF‐related signaling pathways and their different roles in anxiety and related processes. Then, the role of the CRF system in other neuropsychiatric diseases is reviewed and the potential role of PFC CRF signaling in the regulation of anxiety disorders is discussed. Although other signaling pathways are potentially involved in the process of anxiety, CRF in the PFC primarily modulates anxiety disorders through the activation of corticotropin‐releasing factor type1 receptors (CRF‐R1) and the excitation of the cAMP/PKA signaling pathway. Moreover, the main signaling pathways of CRF involved in sex differentiation in the PFC appear to be different. In summary, this review suggests that the CRF system in the PFC plays a critical role in the occurrence of anxiety. Thus, CRF signaling is of great significance as a potential target for the treatment of stress‐related disorders in the future.