bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overload-Checking and Edge-Finding for Robust Cumulative Scheduling
Authors: Fahimi Hamed , Quimper Claude-Guy 
Published: July 2023

Scheduling frameworks are not necessarily stable. The aim is to introduce schedules resistant to disruptions such as when resources become unavailable, the supply chain for them breaks down, etc. A schedule is robust if it absorbs some level of unforeseen events when at most a certain number of activities are delayed. Taking advantage of constraint programming, we present two new filtering algorithms for a constraint that models cumulative scheduling problems in robust contexts where up to [Formula: see text] out of [Formula: see text] tasks can be concurrently delayed while keeping the schedule valid. We adapt the overload-checking and edge-finding filtering rules for this framework. We show that our robust versions of these algorithms run in [Formula: see text] and [Formula: see text], respectively, where [Formula: see text] denotes the number of distinct capacities of all tasks. This achievement implies that the complexities of the state-of-the-art algorithms for these techniques are invariable when [Formula: see text] is constant. Experiments illustrate that our algorithms scale, with respect to [Formula: see text] and [Formula: see text]. As a practical application, the experimental results on a special case of crane assignment problem also verify a stronger filtering for these methods in terms of backtrack numbers as well as computation times when used in conjunction with time tabling. Finally, in order to show that our CP-based algorithms improve to solve a robust scheduling problem, we make a comparison against temporal protection as an external robust scheduling approach. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms – Discrete. Funding: H. Fahimi received funding from Shahid Chamran University of Ahvaz with [Grant number SCU.MC1402.44132]. C.-G. Quimper was funded by a NSERC Discovery Grant from Canada. Supplemental Material: The e-companion is available at https://doi.org/10.1287/ijoc.2021.0138 .
Influence of perinatal distress on adverse birth outcomes: A prospective study in the Tigray region, northern Ethiopia
Authors: Misgina Kebede Haile , Levine Lindsay , Boezen H. Marike , Bezabih Afework Mulugeta , van der Beek Eline M. , Groen Henk 
Published: July 2023

Background
In low-income countries, where socioeconomic adversities and perinatal distress are common, adverse birth outcomes are significant public health problems. In these settings, perinatal distress, i.e., high symptoms of anxiety, depression, and/or stress during pregnancy, may be linked with adverse birth outcomes. However, few prospective studies have investigated the impact of perinatal distress on adverse birth outcomes such as preterm birth (gestational age <37 weeks), low birth weight (<2.5 kg), and small for gestational age birth (birth weight below the 10th percentile for gestational age and sex).

Objectives
Our main objective was to assess the influence of perinatal distress on adverse birth outcomes. Secondly, to investigate if perinatal distress is an independent risk factor or a mediator in the pathway between socioeconomic adversity and adverse birth outcomes.

Methods
In a prospective cohort study following 991 women from before 20 weeks of gestation until delivery in northern Ethiopia, we collected self-reported data on distress at a mean of 14.8 (standard deviation [SD] = 1.9) and 33.9 (SD = 1.1) weeks of gestation. Distress was measured using the Edinburgh Postnatal Depression Scale, the anxiety subscale of the Hospital Anxiety and Depression Scale, and the Perceived Stress Scale. To determine birth outcomes, gestational age was estimated from the last menstrual period, fundal palpation, and/or ultrasound, while birth weight was obtained from delivery records and measured within three days after birth for those delivered at home. Logistic regression and mediation analysis were employed to evaluate the impact of perinatal distress on adverse birth outcomes.

Results
Perinatal anxiety (OR [95% CI] 1.08 [1.02, 1.13]), depression (1.07 [1.03, 1.11]), stress (1.14 [1.07, 1.22]), and total distress (1.15 [1.07, 1.23]) were all associated with low birth weight, and small for gestational age birth but none did with preterm birth. Mediation analysis demonstrated that perinatal distress was a mediator in the pathway between socioeconomic adversity and adverse birth outcomes.

Conclusion
Our study revealed that perinatal distress was linked with adverse birth outcomes and acted as a mediator between socioeconomic adversity and these outcomes. Our findings highlight the importance of screening women for distress and providing appropriate interventions, focusing on women experiencing socioeconomic adversity. Integrating mental health services into primary maternal care in low-income countries could be an effective approach to achieve this.
Combined use of non-steroidal anti-inflammatory drugs and symptomatic slow-acting drugs in musculoskeletal diseases
Authors: Karateev A. E. , Lila A. M. , Parfenov V. A. , Khokhlova M. N. , Strakhov M. A. 
Published: July 2023

Musculoskeletal diseases, such as osteoarthritis (OA), nonspecific back pain (NBP), and periarticular soft tissue pathology (PSTP – tendinitis, enthesitis, bursitis, etc.) are one of the most common reasons for visiting general practitioners. The treatment of this pathology is based on the complex use of drugs and non-drug methods for maximum pain control and lost function restoration. Considering the common pathogenesis of musculoskeletal pain in OA, NBP, and PSTP, it is advisable to base the therapy of these diseases on a single algorithm. Of course, when prescribing treatment, one should take into account "red flags" (symptoms of life threatening diseases), features of the clinical course, patient's psycho-emotional condition, and comorbid diseases.Development of a unified tactic for the treatment of musculoskeletal pain will significantly reduce the time spent on a diagnostic search and the choice of adequate therapy, which will facilitate the work of a general practitioner. Thus, non-drug approaches (patient education, kinesiotherapy, psychotherapeutic methods, etc.), non-steroidal anti-inflammatory drugs (NSAIDs) and symptomatic slow-acting drugs (SYSADOA) seem to be the most rational approach in the debut of the treatment of OA, NBP and PSTP. Among NSAIDs, celecoxib seems to be one of the optimal drugs in terms of efficacy and safety, and among SYSADOAs – diacerein. There is evidence that the combined use of these drugs may increase their analgesic and anti-inflammatory potential.
Association of <I>TNFAIP3</I> (rs10499194) and <I>TNF-α</I> (rs1800629) gene polymorphisms with susceptibility to systemic lupus erythematosus with juvenile onset and its clinical phenotypes in the Russian pediatric population
Authors: Krylov M. Yu. , Kaleda M. I. , Samarkina E. Yu. 
Published: July 2023

Numerous recent studies have shown that TNFAIP3 and TNF-α gene polymorphisms are associated with susceptibility to certain autoimmune and inflammatory diseases, including systemic lupus erythematosus (SLE), systemic scleroderma, rheumatoid arthritis, psoriasis, etc. However, the results of studies on associations between these polymorphisms and the risk of developing SLE in children are ambiguous and few in number.Objective: to test the hypothesis of a possible association between the rs10499194 polymorphism of the TNFA1P3 gene and the rs1800629 polymorphism of the TNF-α gene with susceptibility to juvenile SLE (jSLE) and its clinical phenotypes in the Russian pediatric population.Material and methods. Both polymorphisms were studied by allele-specific real-time polymerase chain reaction in 63 children (15 boys and 48 girls) with a confirmed diagnosis of jSLE, whose mean age was 12.3±3.2 years (3–17 years), and the mean duration of the disease was 4.1±2.4 years. Data on the frequency of genotypes and alleles of the corresponding TNFA1P3 and TNF-α gene polymorphisms in 309 healthy unrelated blood donors over the age of 18 years (20–45 years) were used as controls.Results and discussion. The study showed that the frequency of the rs10499194T mutant allele of the TNFA1P3 gene in patients with jSLE was significantly lower compared to the control (20.6 and 30.7%; p=0.023), and its carriage slightly reduced the risk of developing SLE (odds ratio, OR 0.58; 95% confidence interval, CI 0.32–1.05, p=0.053). The frequency of the rs1800629A mutant allele of the TNF-α gene was slightly higher in jSLE compared with controls (38.1 and 26.2%, respectively; p=0.056), and its carriage slightly increased the risk of developing SLE (OR 1.73; 95% CI 0.93–3.16; p=0.056). An analysis of the frequency distribution of the rs10499194 genotypes in groups of patients with and without arthritis revealed significant differences (p=0.003). Carrying genotypes with the mutant T allele (CT+TT genotypes) in jSLE significantly reduced the risk of developing of arthritis (p=0.003). At the same time, the risk of arthritis in carriers of at least one C allele was 3.76 times higher than in carriers of the other allele (p=0.006). No relationship was found between the rs1800629 TNF-α gene polymorphism and the clinical phenotypes of jSLE.Conclusion. The rs10499194T mutant allele statistically significant reduces the risk of arthritis development as one of the clinical manifestations of jSLE, and the rs1800629A mutant allele of the TNF-α gene is associated with a tendency to increase the risk of jSLE.
Simulation for formation process of atomic orbitals by the finite difference time domain method based on the eight-element Dirac equation
Authors: Mutoh Hideki 
Published: July 2023

Abstract
Using the finite difference time domain (FDTD) method based on the eight-element Dirac equation, we found that a stable Dirac field wave packet with low velocity can be created without explicit consideration of Zitterbewegung (the rapid oscillatory motion of elementary particles), which is difficult in one-dimensional simulations. Furthermore, we successfully simulated the formation process of atomic orbitals for the first time without any physical approximations by calculating the eight-element Dirac field propagation in the central electric force potential. Initially, a small unstable orbital appears, which rapidly grows and results in a large stable orbital with a radius equal to the Bohr radius divided by the atomic number, as given by the solution of the Schrödinger equation. The FDTD calculation based on the conventional four-element Dirac equation cannot produce such reasonable orbitals owing to the spatial asymmetry of the

4
×
4

4\times 4

Dirac matrices. This method has the potential to be used for transient analyses of not only atomic or molecular orbitals but also interactions among elementary particles.
Demographic and clinical factors associated with psychological wellbeing in people with chronic, non-specific musculoskeletal pain engaged in multimodal rehabilitation: –a cross-sectional study with a correlational design
Authors: Wiitavaara Birgitta , Rissén Dag , Nilsson Annika 
Published: July 2023

Abstract

Objectives
To investigate which demographic and clinical factors were associated with psychological wellbeing in working-aged people in multimodal rehabilitation for musculoskeletal disorders.

Methods
116 participants met the criteria for inclusion: persistent or intermittent pain for at least three months; pain that adversely impacts daily life; potential for active change despite pain; no co-morbidity or condition that will hinder participation in the rehabilitation program. Primary outcome was psychological wellbeing and independent measures were general, physical and mental health, pain intensity, limitations in daily life, depression and sleep.

Results
The results show decreased odds of psychological wellbeing for persons rating high on depression. The results remained significant after adjusting for sex and age. Being a woman increased the odds of high psychological wellbeing. Logistic regression showed that psychological wellbeing was not significantly associated with pain intensity; sleep; functional limitations; general, physical, or mental health. None of the other independent variables was significantly associated with high vs. low psychological wellbeing.

Conclusions
Depression turned out to be significantly related to psychological wellbeing, contrary to pain and limitations in daily life. If further studies with larger, random samples can confirm these results, this knowledge may be important both in clinical settings and in future research.
Prognostic significance of NT-proBNP and sST2 biomarkers in patients with post-myocardial infarction heart failure after a coronavirus infection
Authors: Kalashnikova N. M. , Zaitsev D. N. , Govorin A. V. , Chistyakova M. V. , Balzhitov B. T. 
Published: July 2023

Aim. To determine the prognostic significance of N-terminal pro-brain natriuretic peptide (NT-proBNP) and soluble ST2 (sST2) in patients with post-myocardial infarction heart failure after a coronavirus disease 2019 (COVID-19)Material and methods. Three following groups were formed: in patients of group I (main), who underwent inpatient treatment for COVID-19, the cause of heart failure (HF) was prior Q-wave myocardial infarction; in patients of group II (comparison) without COVID-19, the cause of HF was prior Q-wave myocardial infarction; Group III (comparison) — patients with HF of ischemic origin without postinfarction cardiosclerosis and COVID-19. Statistical processing was carried out using the software package IBM SPSS Statistics Version 26.0.Results. The patients of all three groups included in the present study were comparable. After 6 months in group I, HF course worsening was recorded. In patients of groups I and II, an increase in NYHA HF class from 2 to 3 and 4 was recorded, in contrast to patients of group III, among whom the number of patients with class 3 HF decreased by 25% due to compensation to class 2. Patients of the studied groups, who had elevated serum levels of NT-proBNP and sST2, had more pronounced structural and functional myocardial disorders than patients with normal levels of these biomarkers. Using analysis of adverse cardiovascular events, such as recurrent myocardial infarction, cerebrovascular accident, hospitalization due to coronary artery disease, decompensated HF, which required hospitalization, a predictive model was developed using a neural network. There were following most important factors of the developed model: age, level of NT-proBNP and sST2, lung involvement according to computed tomography.Conclusion. Modern biomarkers NT-proBNP and sST2 have sufficient predictive value to determine the risk of adverse events in HF.
Prediction of early mortality after cardioverter-defibrillator implantation for primary prevention of sudden cardiac death: focus on transthoracic echocardiography
Authors: Ilov N. N. , Stompel D. R. , Boytsov S. A. , Palnikova O. V. , Nechepurenko A. A. 
Published: July 2023

Aim. To study the mortality rate of acute decompensated heart failure (ADHF) in patients with heart failure with reduced ejection fraction (HFrEF) within a year after implantation of cardioverter-defibrillator (ICD), to evaluate the potential of its prediction using transthoracic echocardiography.Material and methods. The study included 384 patients with NYHA class 3-4 heart failure with left ventricular ejection fraction (LVEF) ≤35%, who were scheduled for ICD implantation for the primary prevention of sudden cardiac death (SCD). After ICD implantation, enrolled patients were followed up for a year to record the primary endpoint of death due to ADHF.Results. During the 1-year follow-up, the primary endpoint was recorded in 38 patients (10%). A univariate logistic regression identified 14 echocardiographic parameters with the highest predictive potential (p<0,1) associated with the studied endpoint. Based on multivariate regression analysis, a prognostic model was developed, which included three factors with the highest statistical significance: LVEF, right atrial (RA) medial-lateral size, and pulmonary artery systolic pressure. The diagnostic efficiency of the model was 78,7% (sensitivity, 82,4%; specificity, 78,3%). A decrease in LVEF ≤28% and an increase in (RA) medial-lateral size ≥3,9 cm were found to be independent predictors of the studied endpoint.Conclusion. Approximately 10% of HFrEF patients selected for ICD implantation for primary prevention of SCD die due to ADHF during the 1-year follow-up. Transthoracic echocardiography has potential to predict this outcome.
Right ventricular dysfunction as a predictor of complicated course in left heart surgery
Authors: Golukhova E. Z. , Slivneva I. V. , Skopin I. I. , Farulova I. Yu. , Pirushkina Yu. D. , Murysova D. V. , Marapov D. I. , Volkovskaya I. V. 
Published: July 2023

Aim. To analyze the right ventricular (RV) functionality in a cohort of heterogeneous cardiac surgical patients with left-sided valvular heart disease and determine the contribution of RV dysfunction in the complicated postoperative period according to echocardiography.Material and methods. A single-center prospective study of patients with left heart defects operated on in 2022 was conducted. Age ranged was 20-81 years, with a median age of 58 years. The study was conducted on a PHILIPS EPIQ CVx system using an X5-1 probe.Results. To estimate the risk of a complicated postoperative period depending on various indicators of RV systolic function assessment, ROC-analysis was performed. The ROC curve of the RV free wall longitudinal strain (RV FW LS) was characterized by the highest AUC value among other RV functional measures, equal to 0,81±0,06 (95% confidence interval (CI): 0,68-0,93), p<0,001. A value of 20% was selected as the cut-off point of RV FW LS for predicting a complicated postoperative period. The RV FW LS <20% was 19,2 times more likely to develop a complicated course (95% CI: 5,64 to 65,50), compared with the RV FW LS group ≥20%; p<0,05. The odds of heart failure (HF) in the RV FW LS <20% group were 22,78 times higher (95% CI: 5,90 to 88,04), compared with the RV FW LS ≥20% group; p<0,05.Conclusion. The RV FW LS <20% can be considered an independent predictor of complicated postoperative period with a multiple increase in the risk of complications, mainly the risk of heart failure. The assessment of RV FW LS can significantly help in risk stratification, being the reason for the reclassification of a number of patients in the high-risk group with a possible modification of surgical strategy.
Prediction of in-hospital mortality in patients with ST-segment elevation acute myocardial infarction after percutaneous coronary intervention
Authors: Geltser B. I. , Shahgeldyan K. I. , Domzhalov I. G. , Kuksin N. S. , Kokarev E. A. , Kotelnikov V. N. , Rublev V. Yu. 
Published: July 2023

Aim. Development of models for predicting in-hospital mortality (IHM) in patients with ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) based on multivariate logistic regression (MLR).Material and methods. This retrospective cohort study of 4735 electronic health records of patients (3249 men and 1486 women) with STEMI aged 26 to 93 years with a median of 63 years who underwent PCI was performed. Two groups of persons were identified, the first of which consisted of 321 (6,8%) patients who died in the hospital, while the second — 4413 (93,2%) patients with a favorable PCI outcome. To develop predictive models, univariate logistic regression (ULR) and MLR were used. Model accuracy was assessed using 3 following metrics: area under the ROC curve (AUC), sensitivity, and specificity. The end point was represented by the IHM score in STEMI patients after PCI.Results. Statistical analysis made it possible to identify factors that are linearly associated with IHM. ULR was used to determine their weight coefficients characterizing the predictive potential. IHM predictive algorithms based on GRACE scale predictors, represented both by ULR model and by 5 factors in continuous MLR model, had acceptable predictive accuracy (AUC — 0,83 and 0,86, respectively). The MLR model had the best quality metrics, the structure of which, in addition to 5 GRACE factors, included left ventricular ejection fraction (LVEF) parameters and white blood cell (WBC) count (AUC — 0,93, sensitivity — 0,87, specificity — 0,86) . The greatest contribution to endpoint was associated with the Killip class and LVEF, and the smallest contribution was associated with WBC and the age of patients.Conclusion. The predictive accuracy of the developed MLR models was higher than that of the GRACE score. The model with the structure represented by 5 fac­tors GRACE, LV EF and WBC had the highest quality metrics.
Clinical and economic analysis of empagliflozin therapy in patients with heart failure across the ejection fraction range
Authors: Nedogoda S. V. , Salasyuk A. S. , Barykina I. N. , Lutova V. O. , Popova E. A. 
Published: July 2023

Aim. To evaluate the cost-effectiveness of empagliflozin therapy in patients with heart failure (HF) across the ejection fraction (EF) range in the Russian Fe­­deration.Material and methods. An analysis of the cost of HF management was carried out and an analytical decision-making model was built in MS Excel, which makes it possible estimating the costs of HF management with empagliflozin from the state position.Results. Taking into account the direct costs of adverse events, as well as indirect costs, the potential economic benefit of empagliflozin use for 766028 HF patients with low EF could be RUB 7,6-7,8 billion per year of therapy, while for 5790280 patients with HF with moderately reduced and preserved EF — RUB 27,6-29,6 billion per year of therapy. The potential economic benefit of empagliflozin for 664960 patients with HF immediately after hospitalization for an HF exacerbation could be RUB 1,4-1,6 billion per year of therapy, allowing to prevent 69438 deaths and 60822 repeated exacerbations of HF.Conclusion. Empagliflozin is the optimal regimen for the treatment of patients with HF across the entire EF range, both with and without type 2 diabetes, both in terms of clinical efficacy of treatment and economic feasibility.
LA CONSTRUCCIÓN DEL CANON MODERNO DEL ARTE EN CUENCA A FINES DEL SIGLO XIX E INICIOS DEL SIGLO XX
Authors: Rodríguez Tannia Edith 
Published: July 2023

El presente trabajo analiza cómo se institucionalizó la noción moderna que reguló los cánones del arte plástico en Cuenca a fines del silgo XIX e inicios del siglo XX. Parte de las propuestas teóricas de Bolívar Echeverría sobre el concepto de cultura y el valor del arte y el concepto de canon artístico de Carlos Rojas. Luego, revisa las fuentes documentales sobre el discurso estético cuencano de la época estudiada desde una perspectiva histórica para contextualizar el análisis de los géneros artísticos sobresalientes en la época estudiada. El trabajo concluye que el canon artístico de la plástica en Cuenca tuvo un desarrollo posterior y diverso al que tuvo en Quito.
PEPITAS DE CALABAZA
Authors: Encalada Vásquez Oswaldo 
Published: July 2023

PEPITAS DE CALABAZA
Ciudad Calabaza es la capital del rico, grande y poderoso País de las Calabazas, lugar que está situado más allá del Monte de Piedad.
En esta afamada ciudad viven muchas personas; pero también, naturalmente, muchas, muchísimas calabazas. Las hay de todos los tamaños, desde las chiquitinas hasta las gigantazas, porque todas son calabazas. Las hay también de todos los colores y de todas las formas que se puedan imaginar.