bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Practical Uses of Ten Sefirot: Material Readings in an Early Modern Kabbalistic Collectaneum (MS Michael 473)
Authors: Paluch Agata 
Published: April 2023

AbstractBy the end of the sixteenth century, textual manifestations of kabbalah—a variety of Jewish mysticism that first emerged in medieval Provence and Catalonia—achieved the status of elite but authoritative lore in Eastern and Central Europe, even if at times they stirred religious opposition. At the same time, and especially in the seventeenth century, the so-called practical kabbalah, associated with magic and a talismanic approach to religious ritual, gained substantial popularity among Ashkenazi (i.e., Eastern and Central European) Jews. This study centers on a multiple-text and composite codex, Oxford-Bodleian MS Michael 473, and throws into relief the dynamics of circulation of various kabbalistic traditions in early modern Eastern and Central Europe. By zooming in on a single codex, this article foregrounds the hermeneutic potential of contextual reading of texts in complex manuscripts and of interpreting material choices taken by their cocreators. It does so with a methodological agenda that goes beyond tracing of authorial genealogies, and beyond the sociology of texts and their producers, toward exploring the interpretive relations of literary and material form in early modern handwritten kabbalistic texts. The article showcases a single textual unit, Qabbalat ‘Eser Sefirot, that MS Michael 473 contains, in order to focus on the position of practical kabbalistic texts and practices within the spectrum of kabbalistic traditions of seventeenth- and early eighteenth-century Eastern and Central Europe, ushered in by the contemporary modes of reading and transcription of texts.
ALIGNING PARTICIPATION AND PROTECTION IN THE WOMEN, PEACE AND SECURITY AGENDA
Authors: Turner Catherine , Swaine Aisling 
Published: April 2023

AbstractThis article presents the first feminist doctrinal textual analysis of cross-pillar synergies within thematic resolutions of the United Nations Security Council. Specifically, it examines the pillars relating to ‘participation’ and ‘protection’ under the Women, Peace and Security (WPS) agenda. In attempts to balance agency with victimhood, normative advancement of both pillars has until recently evolved along parallel tracks, with little acknowledgment of how protection relates to women's participation. This article identifies synergies, gaps and productive tensions as the WPS agenda begins to engage with the inter-relationship between the pillars. It outlines critical implications and considerations for any future moves towards cross-pillar congruence.
NET ZERO EMISSIONS AND FREE TRADE AGREEMENTS: EFFORTS AT INTEGRATING CLIMATE GOALS BY THE UNITED KINGDOM AND AUSTRALIA
Authors: Young Margaret A , Clough Georgina 
Published: April 2023

AbstractThe negotiation of the free trade agreement (FTA) between Australia and the United Kingdom promised to integrate trade and climate policies. As a leader of the United Nations Framework Convention on Climate Change (UNFCCC) conference in Glasgow, the UK seemed well-placed to exert pressure on Australia, a country that was yet to embrace a target of net zero emissions by 2050. This article asks whether the FTA achieves this aim. It explains the link between trade liberalisation and climate change, referring to the scale and composition of economic activity and drawing upon examples from energy, agriculture, building and transportation sectors, as well as strategic factors. It provides an original analytical framework to assess the FTA's contributions to climate change goals, pointing to: (1) provisions to strengthen climate commitments, including net zero targets; (2) provisions to facilitate trade and investment in climate-related areas; and (3) provisions relating to enforcement and cooperation. It compares selected initiatives of other FTAs, including the Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP), the European Union–Canada Comprehensive Economic and Trade Agreement (CETA), the UK–New Zealand FTA and the Singapore–Australia Green Economy Agreement. It reviews the FTA's negotiating process and its aftermath, including complaints about public participation. The article's conclusion that the FTA makes minimal contribution to climate change mitigation has implications for the broader quest for mutually supportive trade and climate policies, and, now that a net zero target has been legislated by the newly elected Australian Parliament, for the FTA's future implementation.
Integrating medical rules to assist attention for sleep apnea detection
Authors: Li Jianqiang , Song Xiaoxiao , Lin Yanning , Wang Junya , Guo Dongying , Chen Jie 
Published: April 2023

AbstractSleep apnea is one of the most common sleep disorders. The consequences of undiagnosed sleep apnea can be very serious, increasing the risk of high blood pressure, heart disease, stroke, and Alzheimer’s disease over a long period of time. However, many people are often unaware of their condition. The gold standard for diagnosing sleep apnea is nighttime polysomnography monitoring in a specialized sleep laboratory. However, these diagnoses are expensive and the number of beds is limited, and there is insufficient monitoring in terms of time dimension. Existing methods for automated detection use no more than three physiological signals, but all other signals are also associated with the patient’s sleep. In addition, the limited amount of medical real annotation data, especially abnormal samples, lead to weak model generalization capability. The gap between model generalization capability and medical field needs still exists. In this paper, we propose a method for integrating medical interpretation rules into a long short-term memory neural network based on self-attention with multichannel respiratory signals as input. We obtain attention weights through a token-level attention mechanism and then extract key rules of medical interpretation to assist the weights, improving model generalization and reducing the dependence on data volume. Compared with the best prediction performance of existing methods, the average improvements of our method in accuracy, precision, and f1-score are 3.26%, 7.03%, and 1.78%, respectively. The algorithm tested the performance of our model on the Sleep Heart Health Study data set and found that the model outperformed existing methods and could help physicians make decisions in their practices.
Follow the MAPCA: an unusual source of right pulmonary artery flow
Authors: Dalby Stephen T. , Angtuaco Michael J. 
Published: April 2023

AbstractMajor aortopulmonary collateral arteries in the setting of pulmonary atresia with intact ventricular septum are very rarely encountered, having been documented in only a handful of case reports. We present the right ventriculogram of a patient found to have this rare combination of findings along with right ventricular-dependent coronary artery circulation and unusual supply of the right pulmonary artery.
Where you live explains how much you trust local (and national) institutions: A study of the Italian case
Authors: Angelucci Davide , Vittori Davide 
Published: April 2023

AbstractTrust in national and local institutions is an essential component of democracy. The literature has dealt mainly with the former, while less attention has been given to the latter. This paper advances a novel theoretical approach to inquire about trust in local institutions, which is also used to test national ones. We posit that trust is affected by the perceptions individuals have of the physical space where they live. Both a) the perceived quality of life in the neighbourhood where individuals live and b) the neighbourhood (perceived) peripherality are hypothesized to affect trust in local (and to a lesser extent) national institutions. We test our hypotheses in Italy, over a large representative sample of more than 40.000 respondents. We show that both variables are crucial predictors of local trust, but only the perceived quality of life predicts national trust. Equally important, social, cultural and economic individual capital does not modify the relation.
Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets
Authors: White Alicia , Stremming Jane , Brown Laura D. , Rozance Paul J. 
Published: April 2023

AbstractInsulin-like growth factor-1 (IGF-1) is a critical fetal growth hormone that has been proposed as a therapy for intrauterine growth restriction. We previously demonstrated that a 1-week IGF-1 LR3 infusion into fetal sheep reduces in vivo and in vitro insulin secretion suggesting an intrinsic islet defect. Our objective herein was to determine whether this intrinsic islet defect was related to chronicity of exposure. We therefore tested the effects of a 90-min IGF-1 LR3 infusion on fetal glucose-stimulated insulin secretion (GSIS) and insulin secretion from isolated fetal islets. We first infused late gestation fetal sheep (n = 10) with either IGF-1 LR3 (IGF-1) or vehicle control (CON) and measured basal insulin secretion and in vivo GSIS utilizing a hyperglycemic clamp. We then isolated fetal islets immediately following a 90-min IGF-1 or CON in vivo infusion and exposed them to glucose or potassium chloride to measure in vitro insulin secretion (IGF-1, n = 6; CON, n = 6). Fetal plasma insulin concentrations decreased with IGF-1 LR3 infusion (P < 0.05), and insulin concentrations during the hyperglycemic clamp were 66% lower with IGF-1 LR3 infusion compared to CON (P < 0.0001). Insulin secretion in isolated fetal islets was not different based on infusion at the time of islet collection. Therefore, we speculate that while acute IGF-1 LR3 infusion may directly suppress insulin secretion, the fetal β-cell in vitro retains the ability to recover GSIS. This may have important implications when considering the long-term effects of treatment modalities for fetal growth restriction.
Rupture Geometry and Slip Distribution of the Mw 7.2 Nippes Earthquake, Haiti, From Space Geodetic Data
Authors: Raimbault B. , Jolivet R. , Calais E. , Symithe S. , Fukushima Y. , Dubernet P. 
Published: April 2023

AbstractOn 14 August 2021 the Mw 7.2 Nippes earthquake struck southern Haiti, rupturing a segment of the Enriquillo‐Plantain Garden Fault system (EPGF), a 300 km‐long strike‐slip fault system that accommodates half of the highly oblique convergence displacement between the Caribbean and the North American plates. We use coseismic surface displacements from Interferometric Synthetic Aperture Radar and Global Navigation Satellite System (GNSS) to estimate the geometry of the rupture through a systematic parametric exploration, determine its mechanism, and relate them to the regional tectonics derived from interseismic GNSS measurements. We show that the earthquake ruptured a north dipping fault (66 ± 4° dip) with a geodetically determined moment release that is 40% reverse and 60% strike‐slip. We cannot conclude whether this north‐dipping structure is the EPGF itself or a distinct fault running parallel to the EPGF. The rupture then evolved to the west on a vertical (86 ± 2° dip) fault parallel to the EPGF, the Ravine du Sud fault, with left‐lateral strike‐slip motion. The coseismic slip distribution of the 2010 Léogane and 2021 Nippes earthquakes, consistent with the transpressional interseismic strain rate field, show a segmentation of the Caribbean–North American plate boundary in southern Haiti and imply a revision in our understanding of the mode of earthquake rupture within the EPGF system.
Mechanisms of Subsidence and Uplift of Southern Patagonia and Offshore Basins During Slab Window Formation
Authors: Ding Xuesong , Dávila Federico M. , Lithgow‐Bertelloni Carolina 
Published: April 2023

AbstractSubduction of bathymetric anomalies (e.g., an active ridge) can alter the morphology of subducted slabs and their coupling to surface processes. A natural laboratory to study these effects is the subduction of the Oceanic Chilean Ridge beneath the South American plate, which led to the formation of the Patagonian slab window. Its formation and subsequent northward migration contributed to the regression of Patagoniense sea and exhumation of marine strata to their present elevation. To date, there is no quantitative analysis of the effects on the sediment routing system of the slab window. We modeled the Neogene topographic change and foreland sedimentary evolution from the Andean Cordillera to Atlantic margin. Our results show that subcrustal‐driven subsidence correlated with accelerated subduction of the Nazca plate is required to explain the timing of the Patagonian transgression and thickness and spatial extent of marine beds during the incursion. In other words, traditional mechanisms, such as foreland flexure and global sea‐level rise, are insufficient. The subsequent regression and accumulation of mid‐Miocene alluvial‐fluvial deposits were associated with the growth of the Cordillera and a possible flattening of Nazca subduction in the middle Miocene. Isostatic uplift of ∼1 km due to lithospheric thinning during slab window formation can explain the foreland exhumation, sediment bypass, and increases in the offshore sedimentation rate. However, spatial‐temporal varying dynamic uplift is required to explain the along‐strike variations in foreland sedimentation. Our study provides new insights into the interplay between slab window formation, crustal deformation, and landscape evolution.
High‐Resolution InSAR Reveals Localized Pre‐Eruptive Deformation Inside the Crater of Agung Volcano, Indonesia
Authors: Bemelmans M. J. W. , Biggs J. , Poland M. , Wookey J. , Ebmeier S. K. , Diefenbach A. K. , Syahbana D. 
Published: April 2023

AbstractDuring a volcanic crisis, high‐rate, localized deformation can indicate magma close to the surface, with important implications for eruption forecasting. However, only a few such examples have been reported, because frequent, dense monitoring is needed. High‐resolution Synthetic Aperture Radar (SAR) is capable of achieving <1 m spatial resolution and sub‐weekly revisit times, but is under‐used. Here we use high‐resolution satellite SAR imagery from COSMO‐SkyMed, TerraSAR‐X, and Sentinel‐1 to detect intra‐crater uplift preceding the November 2017 onset of eruptive activity at Agung, Indonesia. Processing the SAR imagery with an up‐to‐date, accurate, high‐resolution digital elevation model was crucial for preventing aliasing of the deformation signal and for accurate georeferencing. We show that >15 cm of line‐of‐sight shortening occurred over a 400‐by‐400 m area on the crater floor in September‐October 2017, accompanying a deep seismic swarm and flank dyke intrusion. We attribute the deformation to the pressurization of a shallow (<200 m deep) hydrothermal system by the injection of magmatic gases and fluids. We also observe a second pulse of intra‐crater deformation of 3–5 cm within 4 days to 11 hr prior to the first phreatomagmatic eruption, which is consistent with interaction between the hydrothermal system and the ascending magma. This phreatomagmatic eruption created the central pathway used during the final stages of magma ascent. Our observations have important implications for understanding unrest and eruption forecasting, and demonstrate the potential of monitoring with high‐resolution SAR.
Disrupted longitudinal restoration of brain connectivity during weight normalization in severe anorexia nervosa
Authors: Kaufmann Lisa-Katrin , Hänggi Jürgen , Jäncke Lutz , Baur Volker , Piccirelli Marco , Kollias Spyros , Schnyder Ulrich , Martin-Soelch Chantal , Milos Gabriella 
Published: April 2023

AbstractAltered intrinsic brain connectivity of patients with anorexia nervosa has been observed in the acute phase of the disorder, but it remains unclear to what extent these alterations recover during weight normalization. In this study, we used functional imaging data from three time points to probe longitudinal changes in intrinsic connectivity patterns in patients with severe anorexia nervosa (BMI ≤ 15.5 kg/m2) over the course of weight normalization. At three distinct stages of inpatient treatment, we examined resting-state functional connectivity in 27 women with severe anorexia nervosa and 40 closely matched healthy controls. Using network-based statistics and graph-theoretic measures, we examined differences in global network strength, subnetworks with altered intrinsic connectivity, and global network topology. Patients with severe anorexia nervosa showed weakened intrinsic connectivity and altered network topology which did not recover during treatment. The persistent disruption of brain networks suggests sustained alterations of information processing in weight-recovered severe anorexia nervosa.
Increased incidence of vertebral fractures in German adults from 2009 to 2019 and the analysis of secondary diagnoses, treatment, costs, and in-hospital mortality
Authors: Lang Siegmund , Walter Nike , Freigang Viola , Neumann Carsten , Loibl Markus , Alt Volker , Rupp Markus 
Published: April 2023

AbstractThe aim of this cross-sectional study was to present the nationwide rates of hospitalized patients with vertebral fractures over one decade and to comprehensively analyze the treatment characteristics and direct costs incurred in 2019. Therefore, the trends in the incidence rate were quantified based on annual ICD-10 diagnosis codes from all German medical facilities between 2009 and 2019, provided by the Federal Statistical Office (Destatis). The ICD-10 Codes “S12.0-2; S22.0-; S32.0-, and S32.1-2” were evaluated. The relative change from 2009 through 2019 was determined. Using data from the Institute for Hospital Remuneration Systems (InEK) for 2019 the secondary diagnoses, OPS-codes, intensive care unit (ICU) treatment, in-hospital mortality, the proportion of G-DRGs and cumulative costs were evaluated. The documented number of vertebral fractures increased by 45.6% between 2009 and 2019 to an incidence of 150.7 per 100,000 inhabitants. The lumbar spine was most commonly affected with an incidence of 70.5/100,000 inhabitants in 2019 (46.8% of all vertebral fractures). The highest increases were seen in the numbers of subaxial cervical fractures (+ 121.2%) and sacral fractures (+ 306.6%). Of all vertebral fractures in 2019, 63.7% were diagnosed in women and 69.0% in patients aged 70 years or older. Osteoporosis was documented in 17.9% of cases as a concomitant diagnosis. In 10.1% of all cases, an ICU treatment was documented. The in-hospital mortality was 2.0% in 2019. I68D was the most frequently used G-DRG code, accounting for 33.3% of cases. The total direct costs for inpatient treatment in 2019 amounted to €589,205,715. The evaluation of 955,091 vertebral fractures showed a sharp increase in the nation-wide incidence rate. The presented age and sex distribution, the comorbidity profile and the in-hospital mortality rate indicate the importance of comprehensive geriatric assessment and emphasize the need for spinal care centers to be established.
Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells
Authors: Gallego-Murillo Joan Sebastián , Yağcı Nurcan , Pinho Eduardo Machado , Wahl Sebastian Aljoscha , van den Akker Emile , von Lindern Marieke 
Published: April 2023

AbstractIron, supplemented as iron-loaded transferrin (holotransferrin), is an essential nutrient in mammalian cell cultures, particularly for erythroid cultures. The high cost of human transferrin represents a challenge for large scale production of red blood cells (RBCs) and for cell therapies in general. We evaluated the use of deferiprone, a cell membrane-permeable drug for iron chelation therapy, as an iron carrier for erythroid cultures. Iron-loaded deferiprone (Def3·Fe3+, at 52 µmol/L) could eliminate the need for holotransferrin supplementation during in vitro expansion and differentiation of erythroblast cultures to produce large numbers of enucleated RBC. Only the first stage, when hematopoietic stem cells committed to erythroblasts, required holotransferrin supplementation. RBCs cultured in presence of Def3·Fe3+ or holotransferrin (1000 µg/mL) were similar with respect to differentiation kinetics, expression of cell-surface markers CD235a and CD49d, hemoglobin content, and oxygen association/dissociation. Replacement of holotransferrin supplementation by Def3·Fe3+ was also successful in cultures of myeloid cell lines (MOLM13, NB4, EOL1, K562, HL60, ML2). Thus, iron-loaded deferiprone can partially replace holotransferrin as a supplement in chemically defined cell culture medium. This holds promise for a significant decrease in medium cost and improved economic perspectives of the large scale production of red blood cells for transfusion purposes.
Bi-glandular and persistent enterovirus infection and distinct changes of the pancreas in slowly progressive type 1 diabetes mellitus
Authors: Fukui Tomoyasu , Kobayashi Tetsuro , Jimbo Erika , Aida Kaoru , Shimada Akira , Oikawa Yoichi , Mori Yasumichi , Fujii Takeshi , Koyama Rikako , Kobayashi Kazuhiko , Takeshita Akira , Yagihashi Soroku 
Published: April 2023

AbstractIn slowly progressive type 1 diabetes mellitus (SPIDDM), the pancreas shows sustained islet inflammation, pancreatitis, pancreatic acinar cell metaplasia/dysplasia (ADM), and intraepithelial neoplasia (PanIN), a precancerous lesion. The mechanisms underlying these changes remain unclear. The presence of enterovirus (EV) encoded-capsid protein 1 (VP1) and -2A protease (2Apro) and the innate immune responses of the pancreas were studied using immunohistochemistry and in situ hybridization in 12 SPIDDM and 19 non-diabetic control pancreases. VP1, 2Apro, and EV-RNA were detected in islets and the exocrine pancreas in all SPIDDM pancreases. Innate immune receptor, melanoma differentiation-associated gene 5 (MDA5), and interferon (IFN)-beta1 were intensified in the islets of SPIDDM patients with short disease duration. However, expressions of MDA5 and IFN-beta1were suppressed in those with longer disease duration. CD3+ T cell infiltration was observed in the VP1- and insulin-positive islets (insulitis) and exocrine acinar cells. CD11c+ dendritic cells (DCs) in islets were scarce in long-term SPIDDM. This study showed the consistent presence of EV, suggesting an association with inflammatory changes in the endocrine and exocrine pancreas in SPIDDM. Suppressed expressions of MDA5 and IFN-beta1, as well as decreased numbers of DCs in the host cells, may contribute to persistent EV infection and induction of ADM/PanIN lesions, which may potentially provide a scaffold for pancreatic neoplasms.