bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cotonou (Bénin) : la ville des déguerpis. Évictions et vulnérabilisation des classes populaires
Authors: Yèdji Narcisse Martial 
Published: February 2025

Cet article analyse, à partir du cas de l’éviction des habitants du quartier Fiyégnon I, l’urbanisation rapide en cours à Cotonou, au Bénin, depuis l’arrivée au pouvoir de Patrice Talon en 2016, décidé à faire de la ville phare du pays une métropole de classe mondiale. Longtemps pratiquées au Bénin, les évictions sont considérées par le régime en place comme cruciales au développement urbain, à commencer par Cotonou, la capitale économique. Dès lors, des territoires stratégiques de la ville, dont plusieurs quartiers populaires qualifiés d’illégaux, vont être confrontés à de brutales évictions au profit d’ambitieux projets de rénovation. Les opérations, marquées de violations multiples, culminent avec la démolition d’une importante partie de Fiyégnon I, un petit quartier côtier du littoral. L’enquête qualitative menée révèle que l’urbanisation en cours se nourrit d’évictions autoritaires, étouffant toute protestation dans un contexte de rapports de force déséquilibrés. Ces évictions, préjudiciables aux populations souvent dépendantes d’activités liées au cadre de vie, telle la pêche à Fiyégnon I, renforcent les injustices socio-spatiales et affectent structurellement les « chances de vie » des déguerpis dont elles accentuent la vulnérabilité.
Jacques Roger et la pratique de l’anachronisme. Aporie de l’histoire des sciences ?
Authors: Bognon-Küss Cécilia 
Published: February 2025

Si Jacques Roger se réclamait explicitement d’une « histoire historienne des sciences » prenant ses distances avec d’une part l’épistémologie historique de Gaston Bachelard ou l’archéologie foucaldienne, et d’autre part la microhistoire et l’histoire sociale des sciences, il nous semble, pour reprendre un mot de Jean Gayon, que sa « manière d’aborder l’histoire des sciences » était cependant intrinsèquement philosophique. Nous examinons ici le jeu ou la tension non résolue entre histoire et philosophie à partir de l’étude de l’usage de l’anachronisme dans les écrits de Jacques Roger, envisagés synchroniquement plutôt que dans leur succession chronologique. Paradoxalement, cette pratique de l’anachronisme nous semble refléter les difficultés philosophiques propres à l’histoire des sciences, telles que Roger les fait surgir au niveau du langage, du temps et de la vérité scientifique.
Dosimetric Impact of AAA and AXB Dose Calculation Algorithm in VMAT Treatment Planning for Rectal Tumors
Authors: Srinivasan Karthikeyan , Sekaran Sureka Chandrasekaran , Thangavelu Suresh , Belliappa M. S. 
Published: February 2025

Abstract

Aim:
The study aims to compare the accuracy of Anisotropic Analytical Algorithm (AAA) and acuros XB (AXB) dose calculation algorithms for radiotherapy (RT) planning of rectal tumors.

Materials and Methods:
Treatment plans from 20 patients with previously treated rectal cancer were retrospectively analyzed. All patients underwent VMAT treatment planning using the AAA algorithm in Eclipse (v15.6) system. These plans were recalculated with AXB in Eclipse (v15.6) while maintaining the original multileaf collimator fluence. Dosimetric parameters and gamma analysis (3%/3 mm and 2%/2 mm criteria) were compared between the two algorithms. A paired two-tailed t-test was used to statistically compare dosimetric and gamma analysis results between the AAA and AXB algorithms.

Results:
The results indicate that AAA could be potentially overestimating the dose to planning target volume (PTV). While the mean bowel dose was marginally lower in AAA plans (P = 0.013), doses to other organs at risk (OARs) were slightly higher, suggesting a general overestimation trend. This implies that AAA could be potentially overestimating the dose to OARs and PTV as compared to AXB. The statistical analysis of the Gamma parameters also shows a significant change.

Conclusion:
The results indicate that the dose calculation accuracy of AXB is superior to AAA for rectal cancer RT.
Hypoxia-inducible factor 1α inhibitor reduces hippocampal neuronal ferroptosis
Authors: Liang Zhen , Guo Qi , Zheng Zhaoshi , Lou Yingyue , Zhu Xiaojuan , Liu Songyan 
Published: February 2025

Abstract
Epilepsy is a prevalent neurological disorder in which hippocampal neuronal damage, particularly ferroptosis, plays a critical role. Previous studies have shown that hypoxia-inducible factor 1α is considered an important regulator of cellular stress responses and has been confirmed to play a critical role in the occurrence of various diseases. However, the mechanisms by which hypoxia-inducible factor 1α is related to epilepsy and neuronal ferroptosis remain unclear. In this study, we used a pentylentetrazole-induced chronic epilepsy mouse model and treated the mice with intraperitoneal administration of PX-478, a hypoxiainducible factor-1α inhibitor. Our results showed that PX-478 significantly prolonged the latency of epilepsy, reduced seizure severity, and shortened seizure duration. PX-478 also alleviated neuronal damage in the hippocampal CA1 and CA2 regions, reduced levels of reactive oxygen species and malondialdehyde, and increased levels of superoxide dismutase, catalase, and glutathione peroxidase. Transmission electron microscopy showed that PX-478 treatment reduced mitochondrial damage in the hippocampal neurons of epileptic mice, and significantly improved mitochondrial length and area. Additionally, PX-478 preferentially reduced Fe2+ levels and the expression of cyclooxygenase-2, ferritin heavy chain 1 and transferrin in the hippocampus of epileptic mice. It also inhibited the activity of the hypoxia-inducible factor 1α/heme oxygenase-1 pathway. In summary, these findings suggest that PX-478 has the potential to treat epilepsy by inhibiting the hypoxia-inducible factor 1α/heme oxygenase-1 pathway, alleviating oxidative stress, and reducing ferroptosis in hippocampal neurons.
Damage and repair in retinal degenerative diseases: molecular basis through clinical translation
Authors: Zhang Ziting , Ma Junfeng , Shah Wahid , Quan Xin , Ding Tao , Gao Yuan 
Published: February 2025

Abstract
Retinal ganglion cells are the bridging neurons between the eye and the central nervous system, transmitting visual signals to the brain. The injury and loss of retinal ganglion cells are the primary pathological changes in several retinal degenerative diseases, including glaucoma, ischemic optic neuropathy, diabetic neuropathy, and optic neuritis. In mammals, injured retinal ganglion cells lack regenerative capacity and undergo apoptotic cell death within a few days of injury. Additionally, these cells exhibit limited regenerative ability, ultimately contributing to vision impairment and potentially leading to blindness. Currently, the only effective clinical treatment for glaucoma is to prevent vision loss by lowering intraocular pressure through medications or surgery; however, this approach cannot halt the effect of retinal ganglion cell loss on visual function. This review comprehensively investigates the mechanisms underlying retinal ganglion cell degeneration in retinal degenerative diseases and further explores the current status and potential of cell replacement therapy for regenerating retinal ganglion cells. As our understanding of the complex processes involved in retinal ganglion cell degeneration deepens, we can explore new treatment strategies, such as cell transplantation, which may offer more effective ways to mitigate the effect of retinal degenerative diseases on vision.
Stress granules: guardians of cellular health and triggers of disease
Authors: Desai Meghal , Gulati Keya , Agrawal Manasi , Ghumra Shruti , Sahoo Pabitra K. 
Published: February 2025

Abstract
Stress granules are membraneless organelles that serve as a protective cellular response to external stressors by sequestering non-translating messenger RNAs (mRNAs) and regulating protein synthesis. Stress granules formation mechanism is conserved across species, from yeast to mammals, and they play a critical role in minimizing cellular damage during stress. Composed of heterogeneous ribonucleoprotein complexes, stress granules are enriched not only in mRNAs but also in noncoding RNAs and various proteins, including translation initiation factors and RNA-binding proteins. Genetic mutations affecting stress granule assembly and disassembly can lead to abnormal stress granule accumulation, contributing to the progression of several diseases. Recent research indicates that stress granule dynamics are pivotal in determining their physiological and pathological functions, with acute stress granule formation offering protection and chronic stress granule accumulation being detrimental. This review focuses on the multifaceted roles of stress granules under diverse physiological conditions, such as regulation of mRNA transport, mRNA translation, apoptosis, germ cell development, phase separation processes that govern stress granule formation, and their emerging implications in pathophysiological scenarios, such as viral infections, cancer, neurodevelopmental disorders, neurodegeneration, and neuronal trauma.
Persistent epithelial defect following photorefractive keratectomy: A case presentation and review of contributing factors
Authors: Alabbasi Omar M. , Al Barri Ma’an A. , Alzahrani Sumayah A. , Albadawi Shatha A. 
Published: February 2025

Abstract
Photorefractive keratectomy (PRK) is a commonly performed refractive surgery that has pain as one of the most encountered adverse effects postoperatively. Hence, topical nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed post-PRK. While there is conflicting evidence on their impact on delayed epithelialization, this is not a concern if the epithelium heals promptly with standard treatment. However, persistent epithelial defect (PED) is a serious problem that can lead to devastating complications. Here, we report on a patient with Vitamin D deficiency who underwent uneventful PRK. Despite receiving full-standard treatment, the patient developed a PED with no identifiable underlying cause. This case underscores the need to reconsider the routine use of NSAIDs post-PRK and suggests a potential link with Vitamin D deficiency.
Compliance of Manufacturer Medicine Labels to the National Regulation in a State Hospital in Sri Lanka
Authors: Tharmalinga Sharma Jegath Janani , Senadheera Savini Gunitha , Samaranayake Nithushi Rajitha 
Published: February 2025

Abstract

Background:
Nonstandard pharmaceutical or manufacturer labels may lead to medication errors. Therefore, label content and design are specified and monitored through regulatory frameworks. The aim of this study was to assess the availability of vital information in manufacturer labels of medicines used in a selected state hospital and adherence to the guidelines on labelling of medicines (GLM V1.0) of the National Medicines Regulatory Authority (NMRA), Sri Lanka.

Methods:
Three hundred randomly selected medicine manufacturer labels were assessed using a checklist developed based on GLM V1.0.

Results:
Of the 300 labels, 89.6% complied with the recommended format of the generic name followed by its pharmaceutical form and strength, and 84.0% specified their pharmacopeial monograph. Almost 40% were substandard, lacking at least one essential piece of information required by regulation. The strength of the medicine was not indicated in the principal display panel (PDP) of 5.3% of medicines. 5.0% of labels for various strengths of the same medicine or different medicines looked alike. Other observed flaws were missing necessary information and look-alike labels, reflecting a lack of quality control.

Conclusion:
Divergence from specified standards demonstrates the need for a multifaceted approach by the NMRA to prevent ambiguous labels. Key calls to action for policymakers include better manufacturer guidance, stronger pre-submission assessments, rejecting non-standard labels, and introducing barcode readers.
Effectiveness of Nurse-led Heart Failure Transitional Care Services in Improving Clinical Outcomes and Applicability to Low-resource Settings: A Meta-analysis
Authors: Koontalay Apinya , Samai Thanistha , Samutalai Chatchapong , Onthuam Wasinee , Fonghiranrat Duan 
Published: February 2025

Abstract
Nurse-led interventions are tailored to the specific needs of heart failure (HF) patients, facilitating the transfer of knowledge in ways that are more feasible and applicable within the context of diverse healthcare settings. These programs emphasize comprehensive discharge planning, patient education on self-care practices, medication management, and early symptom recognition. The meta-analysis included 11 randomized controlled trials, selected from databases including MEDLINE, EBSCO, CINAHL, and the Cochrane Library. Quality assessment of the included studies was conducted independently by two reviewers. The overall pooled effect showed a relative risk (RR) of 0.69 (95% confidence interval [CI]: 0.54–0.89) for all-cause readmission and a RR of 0.80 (95% CI: 0.71–0.91) for combined outcomes of all-cause readmission and mortality in the nurse-led group compared to the control group. These results indicate that nurse-led transitional care interventions contribute substantially to reducing both readmission rates and mortality among HF patients. The review also explored the applicability of these interventions in low-resource settings, emphasizing their potential to be adapted and implemented effectively in lower-middle-income countries. This review highlights the pivotal role of nurse-led transitional care programs in addressing these challenges by providing close support to patients and their families. Leveraging existing resources and fostering interdisciplinary collaboration are essential in optimizing healthcare delivery in low-resource settings.
Institutionalizing Respectful Maternity Care as a Standard of Care: A Case Study from Maharashtra in India
Authors: Gogoi Aparajita , Manoranjini Mercy , Ravi Tina , Gupta Mamta 
Published: February 2025

Abstract

Background:
There is a need to institutionalize respectful maternity care (RMC) as a standard of care in public health systems.

Aim and Objectives:
This study demonstrates the development, implementation, and impact of an intervention package for providing RMC to women availing antenatal, natal, and postnatal services.

Methodology:
An intervention package was developed in consultation with healthcare providers incorporating, (a) capacity-building workshops to empower healthcare staff, (b) mentoring support for developing action plans, and (c) development of behavior change communication material. Key practices such as allowing birth companions and the development of consent forms for different procedures were institutionalized. Baseline (January 2018) and endline (March 2020) evaluations were conducted using mixed methods in the department of obstetrics and gynecology at a medical college in Maharashtra, India. Exit interviews with 100 antenatal women, in-depth interviews (IDIs) with postnatal women (19 in baseline and 8 in endline), and 16-h of labor room observations were conducted.

Results:
Of the 35 types of disrespect and abuse (D and A) instances, 20 were reported by atleast two methods (any two out of exit interviews/IDIs/labor room observations) - hence considered “definite.” A significant improvement was observed in nine types of D and A. However, 11 types of D and A such as issues in providing verbal comfort, using curtains and drapes for examination, provision of changing rooms, taking informed consents for the procedures, and attending to women at her call were still reported/observed at the endline. The interventions led to improved service delivery.

Conclusions:
Written policies and procedures, regular training, focused interventions, and using behavior change communication materials have the potential to enhance RMC. However, despite the interventions, many instances of D and A persisted indicating it to be a systemic problem.
Equity Considerations in Health Economic Evaluations: A Systematic Review of WHO South-East Asia Region Countries
Authors: Sivanantham Parthibane , Anandraj Jeyanthi , Ravel Vanessa , Veerasetty Naveen Kumar , Sahithya Vanjavakam , Kar Sitanshu Sekhar 
Published: February 2025

Abstract
Equity-informative Cost-Effectiveness Analysis (CEAs) can promote fair healthcare access, yet their use in the WHO South-East Asia region (SEARO) is not well understood. This study aims to summarize methodological approaches, equity-relevant groups, health inequality measures, and healthcare provision areas addressed in equity-informative CEAs in SEARO countries. A systematic search was conducted in PubMed, Embase, Scopus, and Tufts CEA registry for equity-informative CEAs from WHO SEARO countries (2014-2023). CEAs with at least two alternative interventions and one equity criterion were included. Data extraction used Microsoft Excel. Interventions’ distributional effects on cost-effectiveness were evaluated qualitatively, and bias was assessed using the CHEERS checklist. Of 828 studies identified, 10 were selected, nine from India (90%) and eight between 2014-2017 8 (80%). Studied groups included children, patients, the general population, adolescent girls, and neonates. All studies used cost-effectiveness analysis; 8 (80%) focused on healthcare providers’ perspectives. Disability-Adjusted Life Years (DALYs) were primary outcome measures in 8 (80%) studies, while 9 (90%) assessed financial risk protection via out-of-pocket expenditure averted. Wealth quintiles were the equity criterion in 9 (90%) studies. About 6 (60%) conducted subgroup analyses and Extended Cost-Effectiveness Analyses (ECEA), with 2 (20%) using the Gini coefficient. Most studies 9 (90%) demonstrated ‘greater value,’ indicating improved public health implications. The scarcity of equity-informed CEAs in SEARO countries, excluding India, underscores the need for broader adoption. Improved public health implications highlight the necessity of equity-informed CEAs. Addressing these issues is essential to advance health equity in the SEARO region.
Pengaruh Harga, Promosi, Orang dan Proses Terhadap Loyalitas Pelanggan (Studi Kausal Pt Kintetsu World Express Indonesia - Jakarta)
Authors: Siska Lina 
Published: February 2025

Penelitian ini bertujuan untuk mempelajari pengaruh Harga, Promosi, Orang dan Proses terhadap Loyalias Pelanggan, baik itu secara parsial maupun secara simultan. Penelitian ini merupakan penelitian kuantitatif. Metode yang dilakukan yaitu dengan kuisioner. Data yang digunakan dalam penelitian ini yaitu data primer dan sekunder, pengumpulan data menggunakan kuisioner online (google forms). Sample dalam penelitian ini yaitu seluruh pelanggan yang masih aktif menggunakan jasa PT Kintetsu World Express Indonesia pada tahun 2024 dengan perwakilan populasi yang dijadikan sample yaitu berjumlah 82 sample dengan menggunakan metode probability sampling dengan pendekatan simple random sampling. Teknik analisis data yang digunakan dalam penelitian ini yaitu regresi linier berganda dengan alat analisis SPSS versi 30. Berdasarkan uji t dalam penelitian ini dapat ditemukan bahwa : (1). Terdapat pengaruh positif dan signifikan antara Harga terhadap Loyalitas Pelanggan PT Kintetsu World Express Indonesia, (2). Tidak ada pengaruh positif (searah) signifikan antara variabel Promosi terhadap Loyalitas Pelanggan PT Kintetsu World Express Indonesia, (3). Terdapat pengaruh positif dan signifikan antara Orang terhadap Loyalitas Pelanggan PT Kintetsu World Express Indonesia, (4). Terdapat pengaruh positif dan signifikan antara Proses terhadap Loyalitas Pelanggan PT Kintetsu World Express Indonesia . Dan berdasarkan uji F dapat disimpulkan bahwa hipotesis (5). Terdapat pengaruh antara Harga, Promosi, Orang dan Proses terhadap Loyalitas Pelanggan PT Kintetsu World Express Indonesia. Berdasarkan hasil penelitian temuan tersebut, disimpulkan bahwa Loyalitas Pelanggan PT Kintetsu World Express Indonesia akan meningkat apabila PT Kintetsu World Express Indonesia mencapai sasaran dengan meningkatkan mutu harga dan pelayanan yang dibutuhkan oleh pelanggan, sehingga pelanggan dapat melakukan pembelian ulang secara berkala (terus-menerus).
Efektifitas Bauran Promosi Dalam Upaya Meningkatkan Jumlah Nasabah Bank Mandiri Di Kota Padang
Authors: Dianti Muthia 
Published: February 2025

Penelitian ini bertujuan untuk menganalisis efektivitas bauran promosi dalam upaya meningkatkan jumlah nasabah Bank Mandiri di Kota Padang. Bauran promosi yang dianalisis meliputi periklanan, promosi penjualan, penjualan pribadi, hubungan masyarakat, pemasaran langsung dan digital. Data didalam penelitian ini dikumpulkan dari 100 orang responden dengan metode survei kuantitatif dengan kuesioner yang disebarkan kepada calon nasabah Bank Mandiri. Data yang dikumpulkan dianalisis menggunakan teknik statistik deskriptif dan regresi untuk mengidentifikasi hubungan antara elemen bauran promosi dan jumlah nasabah. Hasil penelitian menunjukkan bahwa elemen bauran promosi memiliki pengaruh yang signifikan terhadap peningkatan minat menabung, dengan periklanan menjadi elemen yang paling dominan. Iklan yang interaktif dan edukatif serta dengan penawaran menarik terbukti efektif dalam menarik perhatian calon nasabah.
Tren terkini dalam periklanan adalah personalisasi dan segmentasi, di mana perusahaan menggunakan data dan analitik nasabah untuk memahami preferensi dan kebutuhan individu. Dengan pendekatan ini, perusahaan dapat mengirimkan pesan dan promosi yang relevan secara personal, yang membantu meningkatkan tingkat respons nasabah dan konversi. Selain itu, periklanan memiliki kemampuan untuk mempengaruhi keputusan nasabah. Iklan yang persuasif dan informatif dapat menyampaikan informasi mengenai keunggulan produk, fitur unik, dan manfaat yang ditawarkan, sehingga menarik nasabah untuk memilih produk yang memiliki pesan kuat dan sesuai dengan kebutuhan mereka.
Strategi Promosi Produk dan Meningkatkan Penjualan melalui E- commerce pada Vapemu Store
Authors: Dharmawan Nickra Varel , Fauzan Ahmad , Putra Ramdani Bayu 
Published: February 2025

This report presents the findings from the fieldwork conducted at Vapemu Store, focusing on promotional strategies and sales enhancement through e-commerce. The practical work experience provided valuable insights into the significance of innovation in product development and marketing strategies. The team emphasized the importance of introducing new product variants and actively listening to customer feedback, which has proven essential for expanding productivity and market share The project involved effective external communication, serving as a bridge between the fieldwork team, partners, supervising lecturers, and the university institution. A detailed budget was prepared for promotional materials, including banners and souvenirs, to support the marketing efforts The team aimed to motivate Vapemu Store to continue its growth trajectory, improve sales outcomes, and attract a larger consumer base in the future. Recommendations for ongoing development were also provided, highlighting the need for continuous innovation and adaptation to market demands The procedural framework for the project included regular coordination meetings among the fieldwork team, ensuring that activities were well-organized and timely. The report concludes with reflections on the practical experience gained, emphasizing the importance of bridging academic knowledge with real-world business applications Overall, this fieldwork experience not only contributed to the operational success of Vapemu Store but also enriched the students' understanding of practical business dynamics, thereby fulfilling the educational objectives of the internship program.