bluuebunny/crossref_metadata_2025_split huggingface dataset:
ETFs and the price volatility of underlying bonds
Authors: Agapova Anna , Kaprielyan Margarita , Volkov Nikanor 
Published: January 2025

AbstractWe investigate whether exchange traded funds (ETFs) distort bond prices or increase price volatility. Contrary to concerns, we find that ETF ownership of corporate bonds is linked to reduced price volatility, likely due to ETFs absorbing bond illiquidity. Monthly net ETF inflows (outflows) increase (decrease) volatility for investment‐grade bonds but have no effect on high‐yield bonds. Additionally, daily ETF flows negatively correlate with same‐day bond returns. Overall, our results suggest that bond ETFs enhance market efficiency, acting as a liquidity buffer rather than contributing to demand pressure as seen with stock ETFs.
Breaking down global barriers: A multinational and multi‐community approach to combat stigma and enhance mental wellbeing in people with HIV
Authors: Mkhize Ntombenhle , Garrido Jorge , Cole‐Haley Susan , Diallo Dázon Dixon , Maldonado Gabriel , Vernhes Stéphan , Wu YoYo , Cascio Mario 
Published: January 2025

AbstractIntroductionThe Joint United Nations Programme on HIV/AIDS (UNAIDS) Global 2025 targets prioritize action to overcome the collective barriers affecting the people and communities sitting on the outer margins of HIV care. Addressing the social and structural disparities that drive greater HIV prevalence and burden requires well‐resourced, community‐led responses that are fully integrated into national and global HIV initiatives.MethodsThe HIV Community Council (HCC), composed of 10 leaders from diverse global communities, convened to share their insights, amplify the community's voice, and identify barriers and solutions to empower all to live well with HIV through a dynamic, stepwise process of preparative work, deep discussion, prioritization, and consensus.ResultsThe HCC created six recommendations to address two important barriers to living well with HIV: stigma and poor mental wellbeing. These recommendations are informed by best practice and community experience. They include suggestions for developing and delivering actionable solutions at the community level to prompt opportunities for support from existing global and regional organizations.ConclusionThe HCC calls for action to implement community‐endorsed, culturally appropriate, and practical solutions to tackle stigma and poor mental wellbeing and improve the long‐term health of people with HIV.
Hypoxia Combined With Interleukin‐17 Regulates Hypoxia‐Inducible Factor‐1α/Endothelial Nitric Oxide Synthase Expression in Pulmonary Artery Endothelial Cells
Authors: Sun Shuai , Mao Jianjun , Ding Yuan , Liu Lin , Gong Juanni , Yang Suqiao , Li Jifeng , Kuang Tuguang , Miao Ran , Yang Yuanhua 
Published: January 2025

ABSTRACTThe pathogenesis of chronic thromboembolic pulmonary hypertension may be multifactorial and requires further studies. We explored alterations in pulmonary artery endothelial cells under the hypoxic and elevated interleukin‐17 conditions that are commonly present in patients with chronic thromboembolic pulmonary hypertension. We measured the serum interleukin‐17 levels in 10 chronic thromboembolic pulmonary hypertension patients and 10 healthy control persons. The expressions and localisations of hypoxia‐inducible factor‐1α and endothelial nitric oxide synthase were detected in tissues. The levels of hypoxia‐inducible factor‐1α, endothelial nitric oxide synthase, nitric oxide, and reactive oxygen species in cultured pulmonary artery endothelial cells were examined under hypoxia and/or interleukin‐17 treatment. The serum interleukin‐17 level was increased in chronic thromboembolic pulmonary hypertension patients. Hypoxia‐inducible factor‐1α was increased, and endothelial nitric oxide synthase was decreased in chronic thromboembolic pulmonary hypertension pulmonary vascular tissue. After receiving the hypoxia combined with interleukin‐17 treatment, pulmonary artery endothelial cells showed increased levels of hypoxia‐inducible factor‐1α and phospho‐endothelial nitric oxide synthase (Thr495) (p = 0.001 and 0.063, respectively) and a decreased level of endothelial nitric oxide synthase (p < 0.001). In addition, the nitric oxide level was significantly decreased (p = 0.001), whereas the reactive oxygen species level was insignificantly increased in pulmonary artery endothelial cells. Chronic thromboembolic pulmonary hypertension patients might experience increased inflammation and hypoxia due to dysregulation of the hypoxia‐inducible factor‐1α/endothelial nitric synthase pathway in pulmonary artery endothelial cells under inflammation and hypoxia, contributing to the pathogenesis of chronic thromboembolic pulmonary hypertension.
Illuminating the dark mess of fibers: Application of circular cross polarized light in unravelling the bone tissue structure of the dermal pectoral girdle of Metoposaurus krasiejowensis
Authors: Kalita Sudipta , Teschner Elżbieta M. , Konietzko‐Meier Dorota 
Published: January 2025

AbstractCurrent understanding of the histology of the dermoskeleton of tetrapods comes from fossilized and recent remains of skulls, osteoderms, carapace, plastron and other postcranial material which were always investigated using linear cross polarized light (LCPL) microscopy. The pectoral girdle of vast majority of non‐amniote tetrapods, including temnospondyls evolved large ventrally located dermal bones‐ the interclavicle and a pair of clavicles. Despite that, there is a lack of information about the bone tissue structure from these postcranial dermal bones. This study used circular cross polarized light (CCPL) to investigate the bone tissue composition and structure from the pectoral dermoskeleton of Metoposaurus krasiejowensis, a Late Triassic temnospondyl known to have evolved massive pectoral dermal bones which could have played a role in buoyancy control in these aquatic amphibians. This novel technique shines light into the fine structure of interwoven structural fibers (ISF), a common matrix found in ossified dermal tissues, is a mesh of loops and strands of collagen instead of a lattice patterned matrix as described previously by using LCPL in previous studies that dealt with ossified elements of dermal origin. Our result of ISF is achieved by eliminating bone fiber extinction under CCPL visualization. This feature of CCPL also sheds light into the transitional forms between interwoven and parallel‐fibered matrices which was never previously observed. This study shows that the historical understanding of histology of bone tissue from skeletal dermal elements is limited not only due to lack of sampling but also due to the limitations of mineralized tissue visualization with LCPL.
Diagnostic Importance of Cutaneous Manifestations of Neurofibromatosis—A Systematic Review
Authors: Aslam Hina , Jawed Inshal , Farhan Ali , Karmani Vikash , Mirza Agha Muhammad Wali , Alam Farah , Khan Hina , Haseeb Abdul , Alam Mohammad Omer , Iqbal Javed , Sathian Brijesh , Gulzar Abu Huraira Bin 
Published: January 2025

ABSTRACTA class of hereditary diseases known as neurofibromatoses results in tumor growth on tissue from nerves. The spinal cord, nerves, and brain are among the parts of the nervous framework where these tumors can form. Similar to other genetic disorders, neurofibromatosis discloses complicated phenotypes, exhibiting varying benign and malignant tumors and skin lesions. Apart from the symptoms of this disease, its origin has also been observed to be a challenging task for the physician. Tracking signs and indicated symptoms often leads the investigator to a provisional diagnosis. This review aims to present an enhanced, descriptive, and elaborated guide for practitioners to get along with the new and comprehensive cases of neurofibromatosis with diverse presentations. The purpose of this study is to assess the presenting and diagnostic symptoms of individuals with neurofibromatosis types 1 and 2. Research articles were retrieved through electronic databases (Google Scholar, Pub‐Med, EMBASE, ELSEVIER, SAGE, and Cochrane Central Register of Controlled Trials) from its inception till December 2023. Six hundred fifty‐eight studies have been found, of which 14 were selected based on inclusion criteria. The presence of Café au Lait spots, neurofibromas, and schwannomas are definite and distinguished indications of NF1. Identification of the different types of skin lesions completes the diagnosis, and initial therapy can be started.
Uncertainty experienced by the critical patient upon discharge to the general ward: Care proposals from the perspective of Mishel's theory
Authors: Romero‐Pastor Mónica , Ricart‐Basagaña María Teresa , Mariné‐Méndez Albert , Lomero‐Martínez María del Mar , Romaní‐Alfonso Oriol , Rubio‐Rico María Lourdes 
Published: January 2025

AbstractBackgroundThe process of discharging the critical patient to the ward (discharge from critical care to the general ward—DCCW) is often described as an experience involving uncertainty which may affect the patient's quality of life and ability to cope. Coping with uncertainty is an individual response not related to the course of the illness that is dependent on external and internal resources and the ability to utilize them. Mishel's theory of uncertainty identifies aspects of care that can shape the experience of uncertainty associated with the illness.AimTo understand the experiences of uncertainty of critical patients associated with discharge from the intensive care unit (ICU) to glean person‐centred care strategies under such circumstances.Study DesignQualitative study with a phenomenological approach. Between March 2017 and May 2018, 20 in‐depth interviews were conducted on patients recently discharged from an ICU.ResultsThe patients have been organized according to the following pre‐established categories of Mishel's theory: stimulus framework, structure providers and uncertainty assessment. Based on these results, suggestions for the care of the critical patient upon discharge from the ICU are made in each of these categories.ConclusionsApplying Mishel's theoretical perspective to care for the critical patient during the process of discharge to the ward can help identify areas for intervention and improvement. To succeed, there is a need to promote a cultural change in ICUs, empower nurses and provide the necessary resources.Relevance to Clinical PracticeThese findings are relevant and timely given the impact of the experience of critical patients discharge to the ward. Uncertainty management has been identified as an important element in the discharge experience of critically ill patients to the ward because, according to the informants' stories, it can make this transition a healthier process with less emotional impact.
Identification of the Novel HLA‐B*40:01:82 Allele by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual
Authors: Gao Cheng‐yan , Wang Yu‐qing , Ma Li , Hu Xiaozhuang , Cai Xiao‐hong 
Published: January 2025

ABSTRACTThe HLA‐B*40:01:82 allele differs from HLA‐B:40:01:01 by a single synonymous nucleotide in exon 4.
Identification of the Novel HLA‐A*02:1098 Allele by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual
Authors: Jiang Xiao‐xing , Xie Zhi‐cong , Ma Li , Hu Xiao‐zhuang , Cai Xiao‐hong 
Published: January 2025

ABSTRACTThe HLA‐A*02:1098 allele differs from HLA‐A*02:07:01:01 by a single non‐synonymous nucleotide change in exon 3.
The Novel HLA‐B*40:02:39 Allele Characterised by Two Different Sequencing‐Based Typing Techniques
Authors: Dhuyser Adèle , Pérès Michaël , Morel Thomas , Clément Sandra , Aarnink Alice 
Published: January 2025

ABSTRACTThe novel allele HLA‐HLA‐B*40:02:39 differs from HLA‐B*40:02:01:01 by one synonymous nucleotide substitution in exon 2.
The Novel HLA‐DPB1*1617:01 Allele Characterised by Two Different Sequencing‐Based Typing Techniques
Authors: Dhuyser Adèle , Pérès Michaël , Morel Thomas , Clément Sandra , Aarnink Alice 
Published: January 2025

ABSTRACTThe novel allele HLA‐DPB1*1617:01 differs from HLA‐DPB1*05:01:01:01 by one non‐synonymous nucleotide substitution in exon 2.
Endovascular electrocoagulation for the treatment of a basilar artery perforator aneurysm not accessible to the microcatheter
Authors: Dong Linggen , Shui Xinjun , Liu Jie , Wei Dachao , Zhao Yang , Lv Ming 
Published: January 2025

Basilar artery perforator aneurysms (BAPAs) are rare and may be occult on initial imaging due to their small size and susceptibility to intermittent thrombosis.1 2 Conventional treatments for aneurysms (eg, clipping or coiling) have proved challenging.3 Recently, endovascular electrocoagulation has been shown to be effective for BAPAs.1 4 5 Here, we report a case of a ruptured BAPA not accessible to a microcatheter, which was successfully treated by endovascular electrocoagulation (video 1). During endovascular electrocoagulation, the tip of the microguidewire functions as an anode, facilitating thrombosis in the aneurysm or parent artery by attracting negatively charged blood particles after passage of an electric current.4 Postoperative immediate angiography showed that the aneurysm completely disappeared. Digital subtraction angiography was repeated 10 days later and showed no recurrence of the aneurysm. This case demonstrates that endovascular electrocoagulation can serve as a promising alternative to conventional endovascular techniques in selected cases if a microcatheter cannot be advanced into the aneurysm sac.Video 1Technical video demonstrating endovascular electrocoagulation for the treatment of a basilar artery perforator aneurysm not accessible to the microcatheter.
Designing artificial intelligence computing techniques to study heat transfer of a ternary hybrid nanofluid flow: Application of particle swarm optimization and artificial neural network
Authors: Rawat Sawan Kumar , Yaseen Moh , Pant Manish , Ujarari Chandan Singh 
Published: January 2025

This paper investigates the steady, and three-dimensional non-Newtonian and Newtonian ternary nanofluid flow toward a bidirectionally stretching surface. The non-Newtonian model is developed using the Maxwell fluid model with engine oil and the Newtonian model is developed with water as a base fluid. The analysis is done with Aluminium oxide (Al2O[Formula: see text] (spherical-shaped), Carbon nanotubes (CNT) (cylindrical-shaped), and Graphene (platelet-shaped) as nanoparticles. The mathematical model is articulated and it is further solved with similarity transformations. Furthermore, the analysis considers the influence of the Cattaneo–Christov model, magnetic field, and thermal radiation. A dataset is generated by adjusting relevant parameters through the bvp4c function in MATLAB. Then two different artificial intelligence computing techniques using fuzzy particle swarm optimization (FPSO) and artificial neural network (ANN) are developed to analyze the Nusselt number for Newtonian and non-Newtonian flow. The dominant values of the radiation parameter and thermal relaxation parameter have a significant impact on the HT rate, causing an increase in HT rate. The HT rate is seen to be higher for non-Newtonian TNF. The results of this model can be used in various fields including energy generation, air conditioning, nuclear reactor cooling, electronic device cooling, tissue heat conduction, desalination, crop preservation from freezing, and food processing.
The Modern and Ancient Central-Mediterranean Gateways
Authors: Longhitano Sergio G. , Chiarella Domenico , Slootman Arnoud 
Published: January 2025

Gateways, seaways, and straits are physical elements of sedimentary basins that are hierarchically distinguished based on their dimensions and temporal persistence. The term ‘gateway’ applies to any oceanographic or marine connection, regardless of its size (width and length), duration, and depth (shallow vs. deep water). Seaways are broad marine passages, spanning from 100s to 1000s of kilometres in width, and active in the range from 100s of years to 10s of kyr in geological time. Straits are narrower passageways, connecting sub-basins within larger marine areas, persisting for no longer than 10 kyr and producing a distinct sedimentary record as individual depositional systems.
In this paper, we focus on the Modern Central-Mediterranean Gateway (MCMG), nowadays represented by the coalescent Strait of Sicily, Egadi Islands and the Messina Strait. These connections, linking the western with the eastern Mediterranean sub-basins, drive continuous tidally-modulated water exchange and sediment transport, representing an example of a modern gateway. Then, we provide field-based examples of the sedimentary record of the former gateway, referred to as the Ancient Central-Mediterranean Gateway (ACMG), here represented by four major straits that developed during the Pliocene-Quaternary along localized grabens dissecting the southernmost edge of the Italian peninsula. We discuss the geological features of each of these straits, along with their depositional architectures and facies. These elements record the initiation of specific depositional processes, possibly enhanced by a stronger penetration of the Atlantic Water Inflow from the Gibraltar Strait, reinforced by the onset of the northern hemisphere glaciation.
Physical Accessibility Barriers to Medications for Opioid Use Disorder Treatment: A Qualitative Study of Perspectives from Women with Opioid Use Disorder and Health and Criminal Legal Professionals
Authors: Skogseth Emma M. , Brant Kristina , Latkin Carl , Jones Abenaa A. 
Published: January 2025

Introduction The opioid overdose crisis necessitates the development of effective treatment and harm reduction practices. Recent increases in opioid use disorder (OUD) and overdose rates among women in tandem with lower medications for opioid use disorder (MOUD) treatment utilization rates make a case for investigating the barriers faced by women with OUD in accessing MOUD treatment. To inform future interventions, this study examines factors that impede access to MOUD treatment and explores evidence-based solutions through triangulating the perspectives of affected women as well as criminal legal and health professionals who work with women with OUD. Methods Semi-structured interviews ( N = 42) were conducted from May to June 2022 to assess participants’ lived experiences with MOUD treatment. Participants included criminal-legal involved women with a lifetime history of OUD and MOUD use ( N = 20), criminal legal professionals ( N = 10), and substance use disorder (SUD) treatment professionals ( N = 12) who work with women with OUD. We used a thematic qualitative data analysis process to identify common barriers to accessing MOUD treatment. Results The thematic analysis identified three categories of factors impeding MOUD treatment accessibility: (1) financial barriers (including program difficulties procuring grant funding and individuals’ concerns regarding insurance coverage), (2) travel hardships (including inadequate public transportation infrastructure and lack of access to personal vehicles), and (3) insufficient provider availability (including demand that exceeds the supply of open spots in MOUD treatment programs and a limited number of treatment facilities). Conclusion There was substantial consensus among the three groups, and participants identified financial barriers, travel hardships, and insufficient provider availability as barriers to accessing MOUD treatment. Our study's results make a strong case for addressing travel-related hardships. To best serve affected women, solutions such as allocated transportation, gas mileage reimbursement, bus passes, flexible take-home treatment options, and alternative medication dispensing settings should be implemented to mitigate transportation-related barriers to accessibility.
Don't Pop It! Modifying the Balloon Analogue Risk Task for a Course-Based Research Experience
Authors: Kelly Andrew J. , Parrish Audrey E. 
Published: January 2025

Background Relatively few studies focus on Course-Based Undergraduate Research Experiences (CUREs) to improve retention of knowledge and enhance student research experience in the social sciences. Objective We introduced a modified, manual version of the Balloon Analogue Risk Task (BART), in which students engaged in all phases of a research project, including the development of a risk-taking assessment, participant recruitment, scale administration, presentation of the modified BART, data collection, and data entry and analysis. Method To determine the effectiveness of the CUREs, students self-reported their research knowledge and skills using pre–post measures. Additionally, we measured attitudes and perceptions of the student's experience with the research project. Results Results from the learning outcomes demonstrated increased research knowledge and skills and a positive overall experience with the project. Conclusion The modified BART is an effective CURE for engaging undergraduate psychology students enrolled in research methods courses. Teaching Implications Engagement through hands-on research project design and data collection, as demonstrated with the modified BART, may serve to increase the overall retention of information and enhance class experience, potentially creating a pipeline for further engagement in high-impact practices for undergraduate psychology students.
A systematic meta-analysis of the prevalence of diabetic retinopathy
Authors: Li Guang , Wang Ledan , Feng Feifei 
Published: January 2025

Background Diabetic retinopathy (DR), the primary retinal vascular consequence of diabetes mellitus (DM) among people of working age worldwide, is the primary cause of vision impairment and blindness. Despite increasing understanding of the prevalence of DM as a significant public health concern in China, the world's most populous developing nation, there is much to discover about the epidemiology of DR. Objective This work uses a systematic review and meta-analysis to determine the total prevalence of diabetic retinopathy (DR) in China. Methods Using common keywords, we looked up published research on the prevalence of DR in diabetic patients using Google Scholar, PubMed, and Scopus from their founding until 2023. Using random effects models, pooled estimates of DR prevalence and the associated 95% confidence intervals (CI) were computed. Fifteen articles covering 4837 patients with different forms of diabetes were analyzed. The Egger tests refuted the publication bias assumption for the prevalence of DR (P = 0.825, P = 0.057, respectively). Significant heterogeneity was seen in the prevalence of DR (P < 0.01, I2 = 92% and τ2 = 0.0082), PDR (P < 0.01, I2 = 97% and τ2 = 0.0072), and NPDR (P < 0.01, I2 = 84% and τ2 = 0.0039), according to the results of I2 and τ2 statistics. Results The combined prevalence of PDR was 24% (95% CI: 19–28), NPDR was 31% (95% CI: 27–35), and DR was 55% (95% CI: 63–71). Conclusions In summary, DR's prevalence appears slightly higher than that of other studies, with a greater incidence of NPDR. This study emphasises the need for DR screening and treatment in individuals with diabetes.