bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a nomogram to predict overall survival in patients with incidental gallbladder cancer: A retrospective cohort study
Authors: Xie Zhi-Hua , Shi Xuebing , Liu Ming-Qi , Wang Jinghan , Yu Yong , Zhang Ji-Xiang , Chu Kai-Jian , Li Wei , Ge Rui-Liang , Cheng Qing-Bao , Jiang Xiao-Qing 
Published: January 2023

ObjectiveThe aim of this study was to develop and validate a nomogram to predict the overall survival of incidental gallbladder cancer.MethodsA total of 383 eligible patients with incidental gallbladder cancer diagnosed in Shanghai Eastern Hepatobiliary Surgery Hospital from 2011 to 2021 were retrospectively included. They were randomly divided into a training cohort (70%) and a validation cohort (30%). Univariate and multivariate analyses and the Akaike information criterion were used to identify variables independently associated with overall survival. A Cox proportional hazards model was used to construct the nomogram. The C-index, area under time-dependent receiver operating characteristic curves and calibration curves were used to evaluate the discrimination and calibration of the nomogram.ResultsT stage, N metastasis, peritoneal metastasis, reresection and histology were independent prognostic factors for overall survival. Based on these predictors, a nomogram was successfully established. The C-index of the nomogram in the training cohort and validation cohort was 0.76 and 0.814, respectively. The AUCs of the nomogram in the training cohort were 0.8, 0.819 and 0.815 for predicting OS at 1, 3 and 5 years, respectively, while the AUCs of the nomogram in the validation cohort were 0.846, 0.845 and 0.902 for predicting OS at 1, 3 and 5 years, respectively. Compared with the 8th AJCC staging system, the AUCs of the nomogram in the present study showed a better discriminative ability. Calibration curves for the training and validation cohorts showed excellent agreement between the predicted and observed outcomes at 1, 3 and 5 years.ConclusionsThe nomogram in this study showed excellent discrimination and calibration in predicting overall survival in patients with incidental gallbladder cancer. It is useful for physicians to obtain accurate long-term survival information and to help them make optimal treatment and follow-up decisions.
Stomach and duodenum dose–volume constraints for locally advanced pancreatic cancer patients treated in 15 fractions in combination with chemotherapy
Authors: Broggi Sara , Passoni Paolo , Tiberio Paolo , Cicchetti Alessandro , Cattaneo Giovanni Mauro , Longobardi Barbara , Mori Martina , Reni Michele , Slim Najla , Del Vecchio Antonella , Di Muzio Nadia G. , Fiorino Claudio 
Published: January 2023

PurposeTo assess dosimetry predictors of gastric and duodenal toxicities for locally advanced pancreatic cancer (LAPC) patients treated with chemo-radiotherapy in 15 fractions.MethodsData from 204 LAPC patients treated with induction+concurrent chemotherapy and radiotherapy (44.25 Gy in 15 fractions) were available. Forty-three patients received a simultaneous integrated boost of 48–58 Gy. Gastric/duodenal Common Terminology Criteria for Adverse Events v. 5 (CTCAEv5) Grade ≥2 toxicities were analyzed. Absolute/% duodenal and stomach dose–volume histograms (DVHs) of patients with/without toxicities were compared: the most predictive DVH points were identified, and their association with toxicity was tested in univariate and multivariate logistic regressions together with near-maximum dose (D0.03) and selected clinical variables.ResultsToxicity occurred in 18 patients: 3 duodenal (ulcer and duodenitis) and 10 gastric (ulcer and stomatitis); 5/18 experienced both. At univariate analysis, V44cc (duodenum: p = 0.02, OR = 1.07; stomach: p = 0.01, OR = 1.12) and D0.03 (p = 0.07, OR = 1.19; p = 0.008, OR = 1.12) were found to be the most predictive parameters. Stomach/duodenum V44Gy and stomach D0.03 were confirmed at multivariate analysis and found to be sufficiently robust at internal, bootstrap-based validation; the results regarding duodenum D0.03 were less robust. No clinical variables or %DVH was significantly associated with toxicity. The best duodenum cutoff values were V44Gy &lt; 9.1 cc (and D0.03 &lt; 47.6 Gy); concerning the stomach, they were V44Gy &lt; 2 cc and D0.03 &lt; 45 Gy. The identified predictors showed a high negative predictive value (&gt;94%).ConclusionIn a large cohort treated with hypofractionated radiotherapy for LAPC, the risk of duodenal/gastric toxicities was associated with duodenum/stomach DVH. Constraining duodenum V44Gy &lt; 9.1 cc, stomach V44Gy &lt; 2 cc, and stomach D0.03 &lt; 45 Gy should keep the toxicity rate at approximately or below 5%. The association with duodenum D0.03 was not sufficiently robust due to the limited number of events, although results suggest that a limit of 45–46 Gy should be safe.
Pilot study for generating and assessing nomograms and decision curves analysis to predict clinically significant prostate cancer using only spatially registered multi-parametric MRI
Authors: Mayer Rulon , Turkbey Baris , Choyke Peter , Simone Charles B. 
Published: January 2023

BackgroundCurrent prostate cancer evaluation can be inaccurate and burdensome. To help non-invasive prostate tumor assessment, recent algorithms applied to spatially registered multi-parametric (SRMP) MRI extracted novel clinically relevant metrics, namely the tumor’s eccentricity (shape), signal-to-clutter ratio (SCR), and volume.PurposeConduct a pilot study to predict the risk of developing clinically significant prostate cancer using nomograms and employing Decision Curves Analysis (DCA) from the SRMP MRI-based features to help clinicians non-invasively manage prostate cancer.MethodsThis study retrospectively analyzed 25 prostate cancer patients. MP-MRI (T1, T2, diffusion, dynamic contrast-enhanced) were resized, translated, and stitched to form SRMP MRI. Target detection algorithm [adaptive cosine estimator (ACE)] applied to SRMP MRI determines tumor’s eccentricity, noise reduced SCR (by regularizing or eliminating principal components (PC) from the covariance matrix), and volume. Pathology assessed wholemount prostatectomy for Gleason score (GS). Tumors with GS &gt;=4+3 (&lt;=3+4) were judged as “Clinically Significant” (“Insignificant”). Logistic regression combined eccentricity, SCR, volume to generate probability distribution. Nomograms, DCA used all patients plus training (13 patients) and test (12 patients) sets. Area Under the Curves for (AUC) for Receiver Operator Curves (ROC) and p-values evaluated the performance.ResultsCombining eccentricity (0.45 ACE threshold), SCR (3, 4 PCs), SCR (regularized, modified regularization) with tumor volume (0.65 ACE threshold) improved AUC (&gt;0.70) for ROC curves and p-values (&lt;0.05) for logistic fit. DCA showed greater net benefit from model fit than univariate analysis, treating “all,” or “none.” Training/test sets achieved comparable AUC but with higher p-values.ConclusionsPerformance of nomograms and DCA based on metrics derived from SRMP-MRI in this pilot study were comparable to those using prostate serum antigen, age, and PI-RADS.
A model for predicting degree of malignancy in patients with intraductal papillary mucinous neoplasm
Authors: He Xiangyi , Fan Rong , Sun Jing , Ren Yanhao , Zhao Xuesong , Rui Weiwei , Yuan Yaozong , Zou Duowu 
Published: January 2023

Background/ObjectivesThere is no predictive model available to address early stage malignant intraductal papillary mucinous neoplasm (IPMN) including high grade dysplasia (HGD) and pT1a (invasive component≤0.5 cm). The aim of this study was to establish an objective and sufficient model to predict the degree of malignancy in patients with IPMN, which can be easily applied in daily practice and adopted for any type of lesion.MethodsA retrospective cohort study of 309 patients who underwent surgical resection for IPMN was performed. Members of the cohort were randomly allocated to the training or testing set. A detection tree model and random forest model were used for a 3-class classification to distinguish low grade dysplasia (LGD), HGD/pT1a IPMN, and invasive intraductal papillary mucinous cancer (I-IPMC) beyond pT1a.ResultsOf the 309 patients, 54 (17.4%) had early stage malignancy (19 HGD, 35 pT1a), 49 (15.9%) had I-IPMC beyond pT1a, and 206 (66.7%) had LGD IPMN. We proposed a 3-class classification model using a random forest algorithm, and the model had an accuracy of 99.5% with the training set, and displayed an accuracy of 96.0% with the testing set. We used SHAP for interpretation of the model and showed the top five factors (mural nodule size, main pancreatic duct diameter, CA19-9 levels, lesion edge and common bile duct dilation) were most likely to influence the 3-class classification results in terms of interpretation of the random forest model.ConclusionsThis predictive model will help assess an individual’s risk for different stages of IPMN malignancy and may help identify patients with IPMN who require surgery.
The impact of Emotion-focused training for emotion couching delivered as mobile app on self-compassion and self-criticism
Authors: Halamová Júlia , Mihaľo Jakub , Bakoš Lukáš 
Published: January 2023

IntroductionBeing self-compassionate is considered a beneficial emotion regulation strategy. Therefore, the acquisition of emotional skills can raise self-compassion levels and consequently reduce self-criticism.MethodsHence, the goal of the current study was to develop a mobile app based on the empirically proven group version of Emotion-Focused Training for Emotional Coaching (EFT-EC) and test its effectiveness in reducing self-criticism and raising self-compassion and self-protection. The sample consisted of 85 participants, of whom 22.4% were men and 77.6% were women. The mean age was 32.53 (SD = 14.51), ranging from 18 to 74 years. The participants filled out the following scales immediately before and after using the fourteen-day mobile app: The Forms of Self-Criticizing/Attacking &amp; Self-Reassuring Scale (FSCRS), The Sussex-Oxford Compassion for the Self Scale (SOCS-S), and The Short-form Version of The Scale for interpersonal behaviour (s-SIB).ResultsUse of the 14-day EFT-EC mobile app significantly improved self-compassion and self-reassurance and significantly reduced self-criticism compared to pre- and post-measurements.DiscussionThe results are promising as self-criticism is a transdiagnostic phenomenon observed in various kinds of psychopathology and reducing it may prevent the emergence of psychopathologies. Moreover, the mobile app intervention can easily be accessed by a wide range of users, without requiring the services of a mental health professional, and thereby reduces the potential risk of shame or stigmatization.
Timeliness of online COVID-19 reports from official sources
Authors: Espinosa Laura , Altunina Olesia , Salathé Marcel 
Published: January 2023

IntroductionMaking epidemiological indicators for COVID-19 publicly available through websites and social media can support public health experts in the near-real-time monitoring of the situation worldwide, and in the establishment of rapid response and public health measures to reduce the consequences of the pandemic. Little is known, however, about the timeliness of such sources. Here, we assess the timeliness of official public COVID-19 sources for the WHO regions of Europe and Africa.MethodsWe monitored official websites and social media accounts for updates and calculated the time difference between daily updates on COVID-19 cases. We covered a time period of 52 days and a geographic range of 62 countries, 28 from the WHO African region and 34 from the WHO European region.ResultsThe most prevalent categories were social media updates only (no website reporting) in the WHO African region (32.7% of the 1,092 entries), and updates in both social media and websites in the WHO European region (51.9% of the 884 entries for EU/EEA countries, and 73.3% of the 884 entries for non-EU/EEA countries), showing an overall clear tendency in using social media as an official source to report on COVID-19 indicators. We further show that the time difference for each source group and geographical region were statistically significant in all WHO regions, indicating a tendency to focus on one of the two sources instead of using both as complementary sources.DiscussionPublic health communication via social media platforms has numerous benefits, but it is worthwhile to do it in combination with other, more traditional means of communication, such as websites or offline communication.
Understanding older adults' intention to use patient-accessible electronic health records: Based on the affordance lens
Authors: Wang Xindi , Zhao Yuxiang Chris 
Published: January 2023

BackgroundGiven the aging population and the rapid development of the digital society, concerns about promoting older adults' health skills are increasing. Patient-accessible electronic health records (PAEHRs) are implemented globally for aging health safeguards. The demand for using health-related information communication technologies (ICTs) among older adults and the factors that promote their usage intention of PAEHRs need to be studied.MethodsDrawing upon affordance theory, we constructed a research model that integrates four affordance types, aggregation, interactivity, collaboration, and communication, to identify the effects of affordances and attachment to platforms and doctors that contribute to older adults' usage intention on PAEHRs. Online survey data from 498 older adults (above 60 years) were collected and analyzed using partial least square-structural equation modeling.ResultsOur findings demonstrated how PAEHR's affordances facilitate older adults' attachment to platforms and doctors. We found that aggregation (γ = 0.417, P &lt; 0.001) and interactivity (γ = 0.397, P &lt; 0.001) can positively influence older adults' attachment to the PAEHR platform, and collaboration (γ = 0.407, P &lt; 0.001) affordance can positively influence older adults' attachment to doctors on the PAEHR platform. Furthermore, seniors' attachment to the platform (γ = 0.598, P &lt; 0.001) and attachment to the doctor (γ = 0.156, P &lt; 0.01) can both positively influence their usage intention, and attachment to the platform had a positive relationship with attachment to doctors (γ = 0.230, P &lt; 0.001) on the PAEHR.ConclusionThis study enriched the understanding of elders' attachment to doctors on PAEHRs and contributed to the literature on health-related ICT usage targets of older adults. Our findings also shed light on inspiring operators of health-related ICTs to formulate appropriate strategies for aging-friendly design to guide older adults to adopt health-related ICTs in their everyday health information practices.
Knowledge of SARS-CoV-2 antigen detection and proper use of rapid diagnostic self-test among Shanghai residents in China
Authors: Gu Ren-Ping , Zhu Ai-Yong 
Published: January 2023

ObjectivesTo assess and evaluate the knowledge of Shanghai, China, residents on the use of SARS-CoV-2 antigen detection and rapid diagnostic self-test.MethodsA cross-sectional electronic survey using a self-administered questionnaire was sent via the online platform, Sojump, to general individuals. Multiple linear regression analysis was performed to determine the variables associated with knowledge of self-test.ResultsA total of 283 participants were recruited between July 1, 2022 and July 20, 2022 through an online survey. The mean score of knowledge on the tests was 14.33 ± 2.85 (out of 21). The questions concerning the depth of swab insertion and minimum number of swab rotations in the nostril, necessity of bilateral sampling, necessity of rotating and squeezing the swab for 10 times in the extraction buffer tube, and waiting time for the results showed the highest rate of incorrect responses. In the multiple regression analysis model, sex, social status, and source of information were associated with the knowledge on the self-test kits.ConclusionImmediate health education programs should be made available and the kits could be improved appropriately to ensure adequate knowledge. The use of technology should be fully leveraged to achieve accurate self-diagnosis and correct interpretation of the results.
Regional Health Disparities in Hypertension-Related Hospitalization of Hypertensive Patients: A Nationwide Population-Based Nested Case-Control Study
Authors: Lee Woo-Ri , Koo Jun Hyuk , Jeong Ji Yun , Kim Min Su , Yoo Ki-Bong 
Published: January 2023

Objective: This study aims to explore regional health disparities in hypertension-related hospitalizations and confirm this difference according to the states of continuity of care (COC).Methods: We used the National Health Insurance Service National Sample Cohort data from 2002 to 2019. The dependent variable, hypertension-related hospitalization, included hospitalization for hypertensive diseases (I10–I13, I15), ischemic heart disease (I20–I25), and cerebrovascular disease (I60–I69). Nested case-control matching was performed according to age, sex, and income level. We compared hypertension-related hospitalization fractions in urban and rural areas by classifying them according to the state of COC and analyzed them using conditional logistic regression suitable for matched data.Results: The odds of hypertension-related hospitalization of hypertensive patients were higher in the rural areas than in the urban areas; however, as the COC increased, the difference decreased. There was no change in the results according to the COC observation period.Conclusion: To reduce regional health disparities, both the promotion of COC and the improvement of the quality of primary care must be achieved.
Understanding the Salmonella Inactivation Mechanisms of 365, 395 and 455 nm Light Pulses Emitted from Light-Emitting Diodes
Authors: Prasad Amritha , Gänzle Michael , Roopesh M. S. 
Published: January 2023

Salmonella is a foodborne pathogen responsible for several outbreaks in low-water activity (aw) foods. Treatment using light pulses emitted from light-emitting diodes (LED) is an emerging decontamination method to inactivate foodborne pathogens. The objective of this study was to understand the antibacterial mechanisms of light pulses with 365, 395 and 455 nm wavelengths against Salmonella Typhimurium in low-aw conditions. The 365 nm light pulses showed better inactivation efficacy against low-aw S. Typhimurium than the 395 nm light pulses. For instance, the 365 nm LED treatment with an ~217 J/cm2 dose produced a reduction of 2.94 log (CFU/g) in S. Typhimurium cell counts, as compared with a reduction of 1.08 log (CFU/g) produced by the 395 nm LED treatment with the same dose. We observed a significant generation of intracellular reactive oxygen species (ROS) in S. Typhimurium cells after treatments with the 365, 395 and 455 nm light pulses at low-aw conditions. The LED treatments also showed a significant membrane lipid oxidation of S. Typhimurium cells after treatments with 365, 395 and 455 nm light pulses. Overall, a major role of ROS generation was observed in the inactivation efficacy of the 365, 395 and 455 nm light pulses against S. typhimurium at low-aw conditions.
Protocolo para la gestión de Residuos Informáticos, importancia de implementarlo en la Universidad Nacional del Nordeste (UNNE), Argentina
Authors: Glibota Gisela , Pellegrino Luis Ariel , Chiozzi Lucio José , Ramírez Verónica Itatí 
Published: January 2023

El trabajo: “Protocolo para la gestión de Residuos Informáticos, importancia de implementarlo en la Universidad Nacional del Nordeste (UNNE), Argentina.”, se enmarca en los resultados de un proyecto de investigación (año 2019-2022) que viene desarrollando el equipo de docentes investigadores en el Centro de Gestión Ambiental y Ecología (CEGAE) de la Universidad Nacional del Nordeste (UNNE) de la República Argentina.
Este protocolo tiene como objeto, asegurar el correcto cumplimiento de ciertas normas y procedimientos a aplicar en las tareas operativas, como de información y trazabilidad de los RI en la UNNE, para garantizar una correcta actuación en la recogida selectiva, el tratamiento del residuo, garantizar la confiabilidad y transparencia del proceso de reciclaje o disposición final.
Análise dos paramentos físico-químicos no controle de qualidade de amostras hídricas tratadas em ETA's, e a relação entre saúde e desregulações ambientais
Authors: Coutinho João Victor de Sousa , De Oliveira João Victor Xavier , Chanca Natan Lopes , Bergamin Felipe Boldrini , Dias Giselle Intra Pedroti , Santos Thalia de Souza , Santos Bruno de Souza , Lima Igor Pereira 
Published: January 2023

Introdução: Políticas de saneamento básico vem propiciando uma longevidade para as populações contemporâneas, bem como uma melhor qualidade de vida, porém, muitas regiões, sobretudo as carentes, necessitam de métodos como o de tratamento de água. Esse processo é de suma importância para o controle de doenças, a exemplo de parasitoses, e o controle de qualidade físico-químico é essencial para a garantia da efetividade do tratamento. O presente trabalho objetivou avaliar os parâmetros analíticos da físico-química de rotina do laboratório das estações de tratamento de água localizadas no município de Itapemirim. Métodos: Para a elaboração da obra utilizou-se dados obtidos no site da autarquia SAAE-Itapemirim e trabalhos de bases de dados indexadas, encontrados mediante os descritores "saneamento básico"; "saúde pública", "tratamento de água"; "agravos em saúde". A pesquisa descritiva possui caráter qualitativo e quantitativo, e foi elaborada no mês de junho de 2022. Resultados e discussão: Após a avaliação, constatou-se que a grande maioria dos resultados obedece às resoluções vigentes expressas em suas próprias emissões, havendo alterações, em poucas amostras, no parâmetro de turbidez.
Conclusão: Com isso é notório o compromisso de tal autarquia na manutenção quantitativa dos parâmetros físico-químicos analisados, assegurado qualidade no produto entregue a população.
Digital Human Resources Management HUB
Authors: Martins Dora 
Published: January 2023

The focus of this empirical study is to explore the importance of creating a HUB specialized in digital human resources management (HRM). Digital Hubs are collaborative networks that aim to stimulate the adoption of advanced digital technologies that promote interaction between different agents for emerging ideas, tools, and for digital networking. Furthermore, a HUB could provide an overview of digital skills and learning strategies to improve these skills to work in a digital society. The main objective of this research is to explore the role of HRH practitioners as agents of creating, acquiring and diffusing knowledge about digital HRM issues. Thus, this study intends to know several stakeholders’ opinions about the importance of the creation of a collaborative platform to manage sourcing, information, and knowledge. It uses qualitative analysis to collect information based on an exploratory study using a focus group with a group of stakeholders (HRM professors, students, and practitioners) with an interest in the topic, through a collective semi-structured interview. The results show that it is important to create a digital HUB to enhance the use of advanced technology in the development of HRM and to facilitate the digital transformation of the different HRM stakeholders. As main activities to develop, the ones identified are: (1) to create a digital room to improve the learning of HRM students related with tools such as chatbots and avatars; (2) to do regular HRM talks to promote the sharing of new knowledge regarding digital innovations; (3) to define digital HRM working groups to create new knowledge; (4) to develop HRM entrepreneurship projects as well as (5) research projects related to digital issues; and (6) to share a digital HRM Library. We conclude by reflecting the importance of HRM digital transformation and also encourage higher education institutions to become shared and open digital learning spaces. The conclusion provides suggestions for opportunities for future research.