bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug Dependence Due to the Use of Barbiturates: The State of the Art
Authors: Titarenko E. V. 
Published: September 2023

Background: currently, the relevance of the formation of drug dependence on barbiturates, despite a significant decrease in the cases of their prescription, remains prevalent. The breadth of the therapeutic effects of barbiturates determines their use in various branches of medicine, despite the risk of developing dependence and withdrawal syndrome, even in the case of taking therapeutic doses. In addition, the non-drug use of barbiturates in order to achieve a narcotic effect remains relevant.The aim of review: to analyze the data of scientific publications on specific features of the formation of barbituric dependence in various categories of patients, to determine the groups at greatest risk and the possibilities of minimizing the consequences of barbiturate use.Materials and methods: based on the analysis of databases (PubMed/MEDLINE, RSCI, etc.), the current concepts of mechanism of action of barbiturates and the ways of development of mental and physical dependence were analyzed. The factors provoking the emergence of drug dependence are determined.Results: the development of drug dependence when taking barbiturates develops rapidly and is dose-dependent. The features of the formation of barbituric dependence and the development of tolerance are characterized. The risk of developing dependence in the therapeutic use of barbiturates is especially high in the elderly.Conclusions: to prevent and possibly reduce the risk of drug dependence, the main areas of research are proposed, namely, the development of more effective and safe drugs analogs of barbituric acid, as well as the correction of the features of the use of barbituric acid drugs (frequency, dosage, dosage form, etc.).
Correlation of HbA1C and Lipid Profile Levels in Type 2 Diabetes Mellitus Patients at M Yunus Hospital
Authors: Handayani Dian , Reza Rahmawati , Dwi Dominica , Jihan Salsabila , Kurnia Hafidzah , Afra Wafiqah 
Published: September 2023

The lipid profile in type 2 diabetes mellitus patients is highly dependent on the HbA1c value. Poor HbA1c values accompanied by insulin resistance are associated with hypertriglyceridemia, decreased HDL levels, and sometimes followed by increased LDL levels. The aims of this study was to determine the correlation between HbA1c and lipid profile of type 2 diabetes mellitus patients. This research was an analytic observational study with a cross sectional design with prospective method. The total sample of 35 patients seeking treatment at the Polyclinic Internal M Yunus hospital. There were lower levels of total cholesterol (158,83 ± 23,96; 201,51 ± 44,95; p=0,032), triglyceride (111,16 ± 48,06; 156,69 ± 76,07; p=0,169), LDL (80,83 ± 22,69; 121,96 ± 42,82; p=0,030) in type 2 DM patients with controlled glycemic control compared to those without control. There was no significant difference in triglyceride levels between on two groups (111,16 ± 48,06; 156,69 ± 76,07; p=0,169). There was a significant correlation between total cholesterol levels r=0,364; p=0,032), HDL (r=-0,377; p=0,026); LDL (r=0,367; p=0,030) with HbA1c levels. Type 2 DM patients with good glycemic control had significantly lower total cholesterol, triglyceride, and LDL levels compared to type 2 DM patients with poor glycemic control.
Keywords: hba1c, lipid profile, type 2 diabetes mellitus
EUROPEAN INTEGRATION STRATEGY FOR TOURISM DEVELOPMENT OF UKRAINE
Authors: PUZYROVA Polina 
Published: September 2023

The purpose of this article is to investigate the essence and features of the implementation mechanism of the European integration strategy for the development of tourism in Ukraine.
Methods of research. The article uses general scientific methods of researching economic phenomena: epistemological analysis, theoretical generalization, methods of analysis and synthesis, induction and deduction, structural-logical analysis, extrapolation, grouping and classification.
Presentation of the main research material. The tourism industry of Ukraine is one of the first to suffer large-scale losses with the start of a full-scale war in Ukraine. The state budget did not receive almost 35% from the tourism industry, which was caused by the suspension or complete exit of tourist companies from the Ukrainian market of the tourism industry. The European integration process of tourism development in Ukraine consists in the implementation of European norms and standards, the spread of its own cultural, historical, geographical achievements in the EU countries. This will lead to the adaptation of European cultural identity in Ukraine and general integration into the European environment. Therefore, one of the key tasks of the Ukrainian tourism industry is the need to actively continue the implementation of the adopted strategic course for European integration through the mechanism of implementing the European integration strategy for the development of tourism in Ukraine. That is why the mechanism for the implementation of the European integration strategy for the development of tourism in Ukraine is becoming relevant, since only with the help of integration into the European space and the adoption of European laws, standards, norms and rules will Ukraine be able to revive and ensure the appropriate level of safe and high-quality tourist flow of Ukrainian tourists to EU countries and others.
Conclusions from the conducted research. It was revealed that as a result of comprehensive actions regarding the implementation of the European integration strategy for the development of tourism in Ukraine, the following advantages will occur: the competitiveness of national and regional tourism products will increase with the prospect of expanding to European markets; the quality of life of the population will increase by ensuring socio-economic growth, environmental safety, consolidation of society, providing access to services in the field of tourism according to European standards; the emergence of new jobs and the expansion of the population's opportunities for employment and self-employment; creation of a modern tourist information industry, as well as ensuring information freedom about the tourist resources of Ukraine in the global information European space.
Keywords: European integration strategy; integration processes; tourism development of Ukraine; tourism industry; mechanism of implementation of European integration strategy; tourism industry; competitiveness; European space; tourist flow.
Probiotic activity of <i>Bacillus subtilis</i> metabolites in experimentally induced dysbiosis in mice
Authors: Lazarev S. А. , Vartanova N. O. , Poddubikov A. V. , Mikhailova N. A. 
Published: September 2023

Scientific relevance. A promising option for dysbiosis correction is the use of metabiotics, products based on metabolites of probiotic microorganisms. During fermentation, Bacillus subtilis bacteria (strains 3H and 1719) produce metabolites that exhibit probiotic properties in vitro. These observations in vitro motivate an in vivo investigation of B. subtilis metabolite effects on colonic mucosal microbiota in mice in experimentally induced dysbiosis and an assessment of the potential of B. subtilis metabolites as metabiotics.Aim. The authors aimed to compare the probiotic activity of B. subtilis 3H and B. subtilis 1719 metabolites and a commercial metabiotic in antibiotic-induced dysbiosis in mice.Materials and methods. The authors induced experimental dysbiosis in BALB/c mice weighing 18–20 g by intraperitoneal injection of gentamicin. For subsequent correction, the test groups received sorbent-bound B. subtilis metabolites, and the comparison group received a commercial metabiotic containing B. subtilis metabolites (VKPM B-2335(3)3) via intragastric injection for 21 days. The quantitative and qualitative analysis of colonic mucosal microbiota included microbial culturing and colony identification by MALDI-TOF mass spectrometry.Results. Antibiotic-induced colonic dysbiosis in mice manifested itself as a decrease in the dominant microbiota and an increase in opportunistic pathogens. After 7 days of metabolite administration, the Lactobacillus population returned to normal in all treatment groups. The mice that received B. subtilis 3H metabolites showed the best results: their Lactobacillus spp. composition corresponded to that of intact animals. The content of Lac+ Escherichia coli returned to 100% in all treatment groups. After 21 days of metabolite administration, the authors observed the elimination of bacteria (Rodentibacter spp., Aerococcus spp.) and fungi (Trichosporon spp., Kazachstania spp.) in the B. subtilis 3H group; Trichosporon spp. (no effect on Kazachstania spp.) in the B. subtilis 1719 group; and Enterococcus spp., Kazachstania spp., and Trichosporon spp. (no effect on Rodentibacter spp. and Aerococcus spp.) in the commercial metabiotic group.Conclusions. Metabolites of B. subtilis strains 3H and 1719 help to restore the diversity and abundance of colonic microbiota in antibiotic-induced dysbiosis. The differences observed in microbiota re-establishment in the treatment groups indicate that there is interstrain variability in the probiotic activity of B. subtilis metabolites.
A didática na formação do professor que ensina Matemática: construções e perspectivas vislumbradas em anais do ENDIPE e da ANPED (2010-2019)
Authors: Silva Andréia Gonçalves da , Lima Francisco José de 
Published: September 2023

Este estudo consistiu na sistematização da primeira parte de um projeto de pesquisa, vinculado ao Programa Institucional de Bolsa de Iniciação Cientifica (PIBIC) 2020/2021, “O lugar curricular da Didática na formação inicial de professores: concepções, saberes e práticas”, e teve por finalidade identificar a produção de pesquisas que enfatizam a importância da Didática na formação de professores. Ancorado em pressupostos da abordagem qualitativa e de natureza básica, o trabalho caracterizou-se como descritivo. Quanto aos procedimentos, tratou-se de estudo do tipo Estado do Conhecimento, no qual o foco foi a análise de Anais do Encontro Nacional de Didática e Prática e Ensino (ENDIPE) e da Associação Nacional de Pós-Graduação e Pesquisa em Educação (ANPED), com o recorte temporal compreendido entre os anos de 2010 a 2019. A análise dos dados permitiu observar que o campo da Educação Matemática apresenta especificidades de duas áreas do conhecimento: Matemática e Educação, e aborda pressupostos para o ensino de Matemática na perspectiva de desenvolvimento cognitivo do aluno. Além disso, verificou-se que o percurso da formação inicial de professores é composto por obstáculos, aprendizagens, desafios e insegurança. Esse percurso proporciona aos futuros professores adquirir habilidades e conhecimentos em virtude de sua profissão, bem como compreender de maneira profunda seu campo de atuação. Ademais, a Didática é um componente curricular norteador para/na formação inicial docente, por estudar os processos de ensino e aprendizagem, com o propósito de orientar o trabalho pedagógico em sala de aula, as estratégias de ensino, o planejamento e execução de aulas.

[1] O lugar curricular da Didática na formação inicial de professores: concepções, saberes e práticas
Prevención del dolor musculoesquelético en trabajadores de dos establecimientos hortícolas, en la provincia de Corrientes, Argentina
Authors: Moro Martin M. , Paunero Ignacio , Aguirre Estrada José M. , Pitton Julieta A. 
Published: September 2023

<p>No existen antecedentes de estimación de prevalencias de dolencias físicas en trabajadores hortícolas de Lavalle, Corrientes. Objetivos: estimar la prevalencia de los Desórdenes Músculo-Esqueléticos (DME) en la columna vertebral y hombros, el esfuerzo físico de la actividad de trasplante de plantines y el impacto de ejercicios preventivos en una población de trabajadores de horticultura intensiva. Se realizó un ensayo clínico – controlado, prospectivo en tres grupos, dos de intervención A – B, por un período de 12 meses y un grupo comparativo C, 6 meses de duración. Se analizó, la prevalencia de vida, anual, trimestral y puntual de dolencias, en columna cervical, dorsal, lumbar y hombros, al inicio, 3, 6, 9 y 12 meses en los grupos de intervención A y B. En el grupo C, al inicio, 3 y 6 meses. La dolencia más prevalente, fue el dolor lumbar 98 %, 94,3 % y 66,7 %, seguida por el dorsal 61,7 %, 52,7 % y 55,3 %; cervical 61 %, 45 % y 55,3 %; hombros 54 %, 40,3 % y 35 % (prevalencias de vida, anual y puntual promedio de los 3 grupos A, B y C). Implementadas las estrategias preventivas, el dolor lumbar bajo un 60 % y 100 % en los grupos de intervención; 33 % en el comparativo, el dolor dorsal, 59,8 % y 100 %, en los grupos de intervención, y 25,4% en el grupo C, el dolor cervical, se redujo 87 %, 100 % y 0 %, en los grupos de intervención, A, B y en el control C, respectivamente. El dolor de hombros, cayó un 76 % en el de intervención y 34% en el grupo comparativo. La actividad de trasplante, se caracterizó como “ligera” y “pesada”, mañana y tarde, respectivamente El dolor lumbar es el DME, más prevalente. Estrategias de prevención, basadas en la combinación de capacitación y ejercicios físicos específicos, permiten reducir las dolencias en trabajadores de horticultura intensiva.</p>
Decyzja o niezbędności wejścia na teren sąsiedniej nieruchomości w celu wykonania robót budowlanych
Authors: Maziarz Aleksander 
Published: September 2023

Artykuł poddaje analizie przesłanki wydania decyzji zezwalającej na wejście do sąsiedniego budynku, lokalu lub na teren sąsiedniej nieruchomości w celu przeprowadzenia prac przygotowawczych lub robót budowlanych. W szczególności zbadano, w jakich sytuacjach wydanie takiej decyzji jest niezbędne do przeprowadzenia prac budowlanych i w jakim zakresie inwestor może korzystać z cudzej nieruchomości. Celem artykułu było zbadanie czy obecnie obowiązujące przepisy nie stanowią nadmiernej ingerencji w prawo własności umożliwiając udzielenie zgody w formie decyzji administracyjnej na wejście na teren cudzej nieruchomości. O ile ustalono, że obecne regulacje nie dokonują nadmiernej ingerencji w prawo własności to jednak ustawodawca nie sprecyzował sposobu naprawnienia szkody powstałej w wyniku korzystania inwestora z cudzej nieruchomości (budynku, lokalu) odsyłając w tym zakresie do kodeksu cywilnego. Taka konstrukcja może powodować, że właściciel nieruchomości będzie musiał sam podjąć często kosztowne i długotrwałe starania w tym zakresie na drodze cywilnoprawnej.
George Tyrrell as a representative of the modernist movement of the Catholic Church
Authors: Захаров П. П. свящ. 
Published: September 2023

В статье раскрывается эволюция взглядов известного английского модерниста католической церкви Джорджа Тиррелла. Исследование его произведений и трудов других католических богословов через призму его биографии показывает, как, будучи католическим священником, членом ордена иезуитов и преподавателем семинарии, увлеченность модернистскими идеями и желанием реформ привели его к полному разрыву с католической церковью. Будучи последовательным приверженцем неосхоластики в первой половине своей жизни, к её концу он пришел к публичному осуждению римского Папы и отрицанию необходимости института самой церкви, что не могло не вызвать жёсткого ответа со стороны официальной иерархии. Анализируется вклад Тиррелла в движение католического модернизма, которое в итоге привело ко II Ватиканскому собору.
The article covers the evolution of George Tyrrell's concepts, who was a famous English modernist of the Catholic Church. The investigation of his works and those of other Catholic theologians through the lens of his biography clearly demonstrates how his devotion to the ideas of modernism and his fervent desire to reform the Catholic Church led him to excommunication, despite him being a Catholic priest, a member of the Jesuit order, and a seminary teacher. Being a persistent supporter of neo-Scholasticism in his early life, later George Tyrrell began to publicly rebuke the Pope and even deny the necessity of the Catholic Church as an institution, which, in turn, could only have caused a harsh reply from its side. The article also analyzes Tyrrell's contribution into Catholic modernism, which eventually resulted in the Vatican II.
Creation and activity of parish councils in 1917–1918. (on the materials of the Tula diocese)
Authors: Резухин П. С. свящ. Резухин П. С. свящ. 
Published: September 2023

В статье рассматривается этап демократизации церковной жизни Тульской епархии в условиях 1917–1918 гг., период крайне сложного процесса в истории Церкви — революционного брожения в приходах, ставшего следствием Февральской революции в России. На основе анализа доступных архивных документов автор воспроизводит картину «приходской революции», когда создавались приходские советы, бравшие в свои руки распоряжение церковной собственностью, решение налоговых вопросов, а также избрание членов причтов. Под влиянием революционных событий благочинные и епархия рассматривались в качестве бесполезных инстанций, обирающих население. В статье делается вывод, что в большинстве случаев «приходская революция» 1917 г. привела к формированию нового утилитарного отношения к Церкви в «низах», смыслом которого стал отказ от содержания церковной организации. Идея выборности органов епархиального управления, привлекавшая духовенство, радеющее за церковное обновление в предреволюционный период, болезненно ударила по положению самих клириков; стала началом разрушения церковной организации.
The article examines the stage of democratization of church life in the Tula diocese in the conditions of 1917–1918, the period of an extremely complex process in the history of the Church-revolutionary ferment in the parishes, which became a consequence of the February Revolution in Russia. Based on the analysis of available archival documents, the author reproduces a picture of the «parish revolution», when parish councils were created, taking control of church property, resolving tax issues, and also electing members of clergy. Under the influence of the revolutionary events, the deans and the diocese were viewed as useless institutions, robbing the population. The article concludes that in most cases the «parochial revolution» of 1917 led to the formation of a new utilitarian attitude towards the Church in the «lower classes», the meaning of which was the rejection of the content of the church organization. The idea of elective bodies of diocesan administration, which attracted the clergy, who were working for church renewal in the pre-revolutionary period, painfully hit the position of the clergy themselves; was the beginning of the destruction of the church organization.
Implementation of repressive measures against the clergy in the territory of Chuvashia in the 1920s–1930s.
Authors: Коршунов  К. О. иер. Коршунов  К. О. иер. 
Published: September 2023

В данной статье рассматривается реализация репрессивной политики советской власти в 20–30 гг. прошлого века. События данного периода являются одними из самых трагичных в истории Церкви, и в наше время продолжается активное изучение архивных материалов событий тех трагичных лет. В статье изучены законодательные акты центральных и местных органов советской власти, направленные на ухудшение социального положения священнослужителей и приведены примеры по архивным данным. Большевистская власть использовала весь возможный спектр репрессивного давления на Православную Церковь: политические, экономические средства и даже физическое уничтожение, пыталась расколоть внутреннее единство Церкви путём создания и активной поддержки обновленческого движения. Учитывая этнокультурные особенности региона, законодательные акты, печатные агитационные материалы издавались на русском и чувашском языках. Гонения священнослужителей на территории Чувашии имели как общие черты, так и свои особенности; для нас, живущих в относительно спокойное время, актуальность представляет не только научный подход к событиям, но и изучение жизни священнослужителей, живших в периоды государственного террора и сохранивших самое важное для каждого христианина — веру в Бога.
This article examines the implementation of the repressive policy of the Soviet government in the 20–30 years of the last century. The events of this period are among the most tragic in the history of the Church, and in our time the active study of archival materials of the events of those tragic years continues. The article examines the legislative acts of the central and local Soviet authorities aimed at worsening the social status of the clergy and provides examples from archival data. The Bolshevik government used all possible range of repressive pressure on the Orthodox Church: political, economic and even physical destruction, tried to split the internal unity of the Church by creating and actively supporting the Renovationist movement. Taking into account the ethnocultural peculiarities of the region, legislative acts, printed propaganda materials were published in Russian and Chuvash. The persecution of the clergy on the territory of Chuvashia had both common features and their own peculiarities. For us who live in a relatively quiet time, the relevance is not only a scientific approach to events, but also the study of the lives of the clergy who lived during periods of state terror and preserved the most important thing for every Christian — faith in God.
Prospects for Russian gas in China
Authors: Kondratov Dmitriy 
Published: September 2023

The article presents an analysis of the current state and forecasts for the long-term development of the Chinese natural gas market, as well as the prospects for increasing Russian supplies of fossil fuels to this market.
It is expected that by the end of 2030 China can catch up and overtake Europe in terms of gas consumption. By 2030, the total demand for gas in China will be 390-560 billion cubic meters, which is almost 1.5 times higher than in 2022.
During the period of economic slowdown, the imbalance of supply and demand in the global hydrocarbon market leads to its destabilization. In order to predict such situations in advance, specialists from international and Russian organizations (International Energy Agency, BP plc, Energy Research Institute of the Russian Academy of Sciences, Institute of Energy Economics of Japan) and consulting companies (IHS Markit) periodically prepare papers on the evolution of world energy markets and the consequences for major countries. gas consumers. Almost all studies are not yet ready to name the period of peak demand for gas in China in the foreseeable future, which gives grounds to name the 21st century of gas transformation.
In this article, a study was made of the Chinese gas market and an analysis of the factors of the long-term dynamics of demand for this energy resource.
The author also made an attempt to assess the expansion of our country&apos;s participation in the Chinese gas market, and prepared interim recommendations on using the potential for developing energy cooperation between China and Russia.
At the same time, the northeastern provinces of China, located near the Russian border, after the launch of the Power of Siberia gas pipeline, will be saturated with Russian gas. At the same time, the insufficient development of gas infrastructure — pipeline capacities, gas storage facilities, distribution networks — in China will not allow increasing exports when Russia builds additional capacities. To an even greater extent, this applies to the Power of Siberia-2 gas pipeline project.

The most promising way to increase Russian gas exports to China is the organization of Russian LNG supplies to the coastal regions of China, where a steady growth in gas demand is predicted.