bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of Evolution-Informed Compassion-Focused Therapy and Buddhist Approaches to Insight Meditation: A Three-Way Exploration
Authors: Gilbert Paul , Huxter Malcolm , Choden  
Published: June 2023

AbstractThis paper explores the overlap and relationship between Compassion-Focused Therapy (CFT) as an evolution-informed, biopsychosocial approach to the mind and two Buddhist approaches to the development of insight and meditation. We present this exploration in terms of a three-way exposition between PG (Paul Gilbert), a clinical psychologist and compassion-focused therapist, MH (Malcolm Huxter), also a clinical psychologist and long-term meditation practitioner, primarily in the Theravada Buddhist traditions, and CH (Choden), a long-term meditation practitioner and monastic of Mahayana Buddhism. We share overlapping but different approaches to the processes of insight, understanding, and the training of compassion.
EMExplorer: an episodic memory enhanced autonomous exploration strategy with Voronoi domain conversion and invalid action masking
Authors: Chen Bolei , Zhong Ping , Cui Yongzheng , Lu Siyi , Liang Yixiong , Sheng Yu 
Published: June 2023

AbstractAutonomous exploration is a critical technology to realize robotic intelligence as it allows unsupervised preparation for future tasks and facilitates flexible deployment. In this paper, a novel Deep Reinforcement Learning (DRL) based autonomous exploration strategy is proposed to efficiently reduce the unknown area of the workspace and provide accurate 2D map construction for mobile robots. Different from existing human-designed exploration techniques that usually make strong assumptions about the scenarios and the tasks, we utilize a model-free method to directly learn an exploration strategy through trial-and-error interactions with complex environments. To be specific, the Generalized Voronoi Diagram (GVD) is first utilized for domain conversion to obtain a high-dimensional Topological Environmental Representation (TER). Then, the Generalized Voronoi Networks (GVN) with spatial awareness and episodic memory is designed to learn autonomous exploration policies interactively online. For complete and efficient exploration, Invalid Action Masking (IAM) is employed to reshape the configuration space of exploration tasks to cope with the explosion of action space and observation space caused by the expansion of the exploration range. Furthermore, a well-designed reward function is leveraged to guide the learning of policies. Extensive baseline tests and comparative simulations show that our strategy outperforms the state-of-the-art strategies in terms of map quality and exploration speed. Sufficient ablation studies and mobile robot experiments demonstrate the effectiveness and superiority of our strategy.
Evaluation of excavation method on point load strength of rocks with poor geological conditions in a deep metal mine
Authors: Luo Pingkuang , Fang Xugang , Li Diyuan , Yu Yisong , Li Huahua , Cui Peng , Ma Jinyin 
Published: June 2023

AbstractIn the field of deep mining engineering, it poses a challenge to promptly determine the mechanical properties of rocks under poor geological conditions through in-situ tests. However, the indirect determination of uniaxial compressive strength (UCS) of rocks can be achieved through the point load strength index (PLSI) test on irregular samples. In the present study, laboratory uniaxial compressive and field PLSI tests were carried out on irregular ore and rock blocks extracted through mechanical mining methods from a stope at a lead–zinc mine in Yunnan Province, China, with a depth of approximately 1000 m. The effects of mechanical excavation and drilling-blasting methods on the PLSI of rocks and ores are compared. It is found that there are significant differences in the point load strength indexes obtained by different excavation methods, and the Is(50) obtained after the mechanical excavation method approximates the actual value of ore and surrounding rocks. Two correction methods were utilized to obtain the point load strength indexes Is(50)-1 and Is(50)-2 of irregular rock samples. The correlation factors (k) linking Is(50) to UCS and Brazilian splitting strength are derived based on testing results. The findings indicate that using the conversion factor (k) recommended by ISRM to predict the UCS of rocks may significantly underestimate the actual strength of rocks in intricate mining environments. This study can serve as a benchmark for analogous deep mining projects.
Research progresses in O3-type Ni/Fe/Mn based layered cathode materials for sodium ion batteries
Authors: Zhao Shengyu , Shi Qinhao , Feng Wuliang , Liu Yang , Yang Xinxin , Zou Xingli , Lu Xionggang , Zhao Yufeng 
Published: June 2023

AbstractSodium ion batteries (SIBs) have attracted great interest as candidates in stationary energy storage systems relying on low cost, high abundance and outstanding electrochemical properties. The foremost challenge in advanced NIBs lies in developing high-performance and low-cost electrode materials. To accelerate the commercialization of sodium ion batteries, various types of materials are being developed to meet the increasing energy demand. O3-type layered oxide cathode materials show great potential for commercial applications due to their high reversible capacity, moderate operating voltage and easy synthesis, while allowing direct matching of the negative electrode to assemble a full battery. Here, representative progress for Ni/Fe/Mn based O3-type cathode materials have been summarized, and existing problems, challenges and solutions are presented. In addition, the effects of irreversible phase transitions, air stability, structural distortion and ion migration on electrochemical performance are systematically discussed. We hope to provide new design ideas or solutions to advance the commercialization of sodium ion batteries.
Alveolar epithelial-like cell differentiation in a dynamic bioreactor: a promising 3D-approach for the high-throughput generation of lung cell types from human induced pluripotent stem cells
Authors: Müller Michelle , Kohl Yvonne , Germann Anja , Wagner Sylvia , Zimmermann Heiko , von Briesen Hagen 
Published: June 2023

Abstract
Purpose
Human induced pluripotent stem cell (hiPSC)-derived lung cell types such as alveolar epithelial cells are promising for toxicological and pharmaceutical in vitro screenings. Reproducible differentiation processes are highly demanded, but protocols which are suitable for the high-throughput generation of lung cell types from hiPSCs are lacking.

Methods
In this study, a new approach for the hiPSC-differentiation in alveolar epithelial-like cells type 2 under dynamic 3D-conditions in a suspension bioreactor is presented. Gene and protein expression analyses of key markers during the embryonal lung development have been performed in comparison to cells differentiated under static 2D-conditions to evaluate the differentiation efficacy of the new bioreactor-based approach. Finally, the resulting cells were infected by SARS-CoV-2 pseudotypes to demonstrate their functionality and suitability for e.g. COVID-19 drug development.

Results
The dynamic bioreactor is suitable to differentiate hiPSCs in spheroids, which express relevant lung markers in each developmental stage on gene and protein level. The 3D method is able to significantly increase the expression of some markers in comparison to conventional 2D differentiation. 3D-differentiated alveolar epithelial-like cells express functional SARS-CoV-2 receptors and can display the viral infection.

Conclusion
The presented dynamic 3D-differentiation is a promising, new approach to generate alveolar epithelial-like cells from hiPSCs as cell source for in vitro lung models.
Design of a haptic obstacle avoidance for low-speed helicopter operations using active sidesticks
Authors: Walko C. , Müllhäuser M. 
Published: June 2023

AbstractHelicopter collisions with obstacles are one of the most frequent and most devastating causes of accidents. To avoid these collisions in low-speed operations a “haptic ticker” cue in form of repetitive impulses as a force feedback was designed for an active sidestick. Various design questions were examined in pilot campaigns using a full flight simulator and four test scenarios. As a result, the pilots always knew which distance-based hazard area (green, yellow, red) they were in. Furthermore, the ticker is disruptive and roughly reduces the handling qualities from Level 1 to Level 2. It is therefore primarily activated as a hazard warning and not as a main input to control the distance. As a warning cue the ticker was evaluated as non-disturbing. The force threshold to detect the direction of a tick was determined. With tick strengths above this threshold, the direction is still not recognised at all in around 2% of the ticks. For the remaining ticks, the accuracy with which the direction is recognised is about 15°. In the fourth scenario, obstacles were moved towards the hovering helicopter, potentially forcing a collision. However, with the ticker a collision occurred in less than 4% of the cases, instead of 84% without the ticker. The ticker was rated as very intuitive and worth recommending. When asked how many accidents of this kind could be prevented with this ticker, all five pilots independently estimated 75%.
Navigating the expanded access investigational new drug protocol for tecovirimat: lessons learned from a public–private hospital partnership during the 2022 NYC mpox outbreak
Authors: Mgbako Ofole , Chan Justin , Pitts Robert A. , DiLorenzo Madeline A. , Knutsen Dorothy , Mazo Dana 
Published: June 2023

Abstract
During the 2022 mpox outbreak, tecovirimat was accessed through an expanded access investigational new drug (EA-IND) protocol. We leveraged a unique public/private hospital partnership in New York City to create a novel infrastructure to navigate the EA-IND’s regulatory requirements and rapidly provide tecovirimat to patients.
THE STRUCTURAL COMPLEXITY OF MODELS OF ARITHMETIC
Authors: MONTALBÁN ANTONIO , ROSSEGGER DINO 
Published: June 2023

Abstract
We calculate the possible Scott ranks of countable models of Peano arithmetic. We show that no non-standard model can have Scott rank less than

$\omega $

and that non-standard models of true arithmetic must have Scott rank greater than

$\omega $

. Other than that there are no restrictions. By giving a reduction via

$\Delta ^{\mathrm {in}}_{1}$

bi-interpretability from the class of linear orderings to the canonical structural

$\omega $

-jump of models of an arbitrary completion T of

$\mathrm {PA}$

we show that every countable ordinal

$\alpha>\omega $

is realized as the Scott rank of a model of T.
AN EGOCENTRIC LOGIC OF KNOWING HOW TO TELL THEM APART
Authors: NAUMOV PAVEL , TAO JIA 
Published: June 2023

Abstract
Traditionally, the formulae in modal logic express properties of possible worlds. Prior introduced “egocentric” logics that capture properties of agents rather than of possible worlds. In such a setting, the article proposes the modality “know how to tell apart” and gives a complete logical system describing the interplay between this modality and the knowledge modality. An important contribution of this work is a new matrix-based technique for proving completeness theorems in an egocentric setting.
Emancipating human rights: Capitalism and the common good
Authors: Salomon Margot E. 
Published: June 2023

AbstractThis article begins with a study of the political economy of welfare capitalism to demonstrate how the private quest for profit was never going to be undermined by the advance of socio-economic rights. Contrary to the conventional view among human rights lawyers, capital draws power from its rights or welfarism. It is in recognizing the role that socio-economic rights play in serving capitalism that the field of international law concerned with structurally transformative human rights can begin to explore how socio-economic rights inhibit alternative forms of social organization. This work then turns to recovering property rights through a study of recent evictions and housing rights case law of the UN Committee on Economic, Social and Cultural Rights that problematizes structural inequities and calls the financialized capitalist system into question. Next this work investigates radical legal positivism in international indigenous rights jurisprudence for how it transcends the private ownership of indigenous lands and control over the means of production. The social function of property rights is then revisited and extended, drawing to a close an article that unearths how socio-economic rights might yet emancipate people from capitalist property relations, alter the underlying structure of the economy, and, in time, sever its concordance with the capitalist welfare state.
A Humid East Asia During the Early Pliocene Indicated by Calcite Nodules From the Chinese Loess Plateau
Authors: Da Jiawei , Breecker Daniel O. , Li Tao , Li Gaojun , Lu Huayu , Ji Junfeng 
Published: June 2023

AbstractUnderstanding the monsoonal climate over East Asia during the warm Pliocene, the closest analog of the future warm climate, could better inform us of the regional hydrological responses to global climate change. However, the variations and controlling mechanisms of the regional hydrology during this warm period are not determined due to discrepancies among different proxy‐derived records. Here we apply a multiproxy approach based on the geochemistry of calcite nodules from a Red Clay sequence located on the southern edge of the Chinese Loess Plateau. Both the trace metal/Ca ratios and the carbon and oxygen isotopic compositions of calcite nodules show low values during 5.4–4.1 Ma and increased during 4.1–3.3 Ma, together indicating a humid climate during the early Pliocene, the onset of drying starting at ∼4.1 Ma and further intensification at 3.6 Ma. The timings of these hydrological transitions are consistent with global temperature changes, underlining the crucial role of meridional thermal gradient in shaping the regional hydroclimate over East Asia by modulating the strength and position of the East Asian summer monsoon.
A novel multifunctional radioprotective strategy using P7C3 as a countermeasure against ionizing radiation-induced bone loss
Authors: Wei Fei , Tuong Zewen Kelvin , Omer Mahmoud , Ngo Christopher , Asiatico Jackson , Kinzel Michael , Pugazhendhi Abinaya Sindu , Khaled Annette R. , Ghosh Ranajay , Coathup Melanie 
Published: June 2023

AbstractRadiotherapy is a critical component of cancer care but can cause osteoporosis and pathological insufficiency fractures in surrounding and otherwise healthy bone. Presently, no effective countermeasure exists, and ionizing radiation-induced bone damage continues to be a substantial source of pain and morbidity. The purpose of this study was to investigate a small molecule aminopropyl carbazole named P7C3 as a novel radioprotective strategy. Our studies revealed that P7C3 repressed ionizing radiation (IR)-induced osteoclastic activity, inhibited adipogenesis, and promoted osteoblastogenesis and mineral deposition in vitro. We also demonstrated that rodents exposed to clinically equivalent hypofractionated levels of IR in vivo develop weakened, osteoporotic bone. However, the administration of P7C3 significantly inhibited osteoclastic activity, lipid formation and bone marrow adiposity and mitigated tissue loss such that bone maintained its area, architecture, and mechanical strength. Our findings revealed significant enhancement of cellular macromolecule metabolic processes, myeloid cell differentiation, and the proteins LRP-4, TAGLN, ILK, and Tollip, with downregulation of GDF-3, SH2B1, and CD200. These proteins are key in favoring osteoblast over adipogenic progenitor differentiation, cell matrix interactions, and shape and motility, facilitating inflammatory resolution, and suppressing osteoclastogenesis, potentially via Wnt/β-catenin signaling. A concern was whether P7C3 afforded similar protection to cancer cells. Preliminarily, and remarkably, at the same protective P7C3 dose, a significant reduction in triple-negative breast cancer and osteosarcoma cell metabolic activity was found in vitro. Together, these results indicate that P7C3 is a previously undiscovered key regulator of adipo-osteogenic progenitor lineage commitment and may serve as a novel multifunctional therapeutic strategy, leaving IR an effective clinical tool while diminishing the risk of adverse post-IR complications. Our data uncover a new approach for the prevention of radiation-induced bone damage, and further work is needed to investigate its ability to selectively drive cancer cell death.
Dissecting the roles of MBD2 isoforms and domains in regulating NuRD complex function during cellular differentiation
Authors: Schmolka Nina , Karemaker Ino D. , Cardoso da Silva Richard , Recchia Davide C. , Spegg Vincent , Bhaskaran Jahnavi , Teske Michael , de Wagenaar Nathalie P. , Altmeyer Matthias , Baubec Tuncay 
Published: June 2023

AbstractThe Nucleosome Remodeling and Deacetylation (NuRD) complex is a crucial regulator of cellular differentiation. Two members of the Methyl-CpG-binding domain (MBD) protein family, MBD2 and MBD3, are known to be integral, but mutually exclusive subunits of the NuRD complex. Several MBD2 and MBD3 isoforms are present in mammalian cells, resulting in distinct MBD-NuRD complexes. Whether these different complexes serve distinct functional activities during differentiation is not fully explored. Based on the essential role of MBD3 in lineage commitment, we systematically investigated a diverse set of MBD2 and MBD3 variants for their potential to rescue the differentiation block observed for mouse embryonic stem cells (ESCs) lacking MBD3. While MBD3 is indeed crucial for ESC differentiation to neuronal cells, it functions independently of its MBD domain. We further identify that MBD2 isoforms can replace MBD3 during lineage commitment, however with different potential. Full-length MBD2a only partially rescues the differentiation block, while MBD2b, an isoform lacking an N-terminal GR-rich repeat, fully rescues the Mbd3 KO phenotype. In case of MBD2a, we further show that removing the methylated DNA binding capacity or the GR-rich repeat enables full redundancy to MBD3, highlighting the synergistic requirements for these domains in diversifying NuRD complex function.
Genetic associations with parental investment from conception to wealth inheritance in six cohorts
Authors: Wertz Jasmin , Moffitt Terrie E. , Arseneault Louise , Barnes J. C. , Boivin Michel , Corcoran David L. , Danese Andrea , Hancox Robert J. , Harrington HonaLee , Houts Renate M. , Langevin Stephanie , Liu Hexuan , Poulton Richie , Sugden Karen , Tanksley Peter T. , Williams Benjamin S. , Caspi Avshalom 
Published: June 2023

AbstractGenetic inheritance is not the only way parents’ genes may affect children. It is also possible that parents’ genes are associated with investments into children’s development. We examined evidence for links between parental genetics and parental investments, from the prenatal period through to adulthood, using data from six population-based cohorts in the UK, US and New Zealand, together totalling 36,566 parents. Our findings revealed associations between parental genetics—summarized in a genome-wide polygenic score—and parental behaviour across development, from smoking in pregnancy, breastfeeding in infancy, parenting in childhood and adolescence, to leaving a wealth inheritance to adult children. Effect sizes tended to be small at any given time point, ranging from RR = 1.12 (95% confidence interval (95%CI) 1.09, 1.15) to RR = 0.76 (95%CI 0.72, 0.80) during the prenatal period and infancy; β = 0.07 (95%CI 0.04, 0.11) to β = 0.29 (95%CI 0.27, 0.32) in childhood and adolescence, and RR = 1.04 (95%CI 1.01, 1.06) to RR = 1.11 (95%CI 1.07, 1.15) in adulthood. There was evidence for accumulating effects across development, ranging from β = 0.15 (95%CI 0.11, 0.18) to β = 0.23 (95%CI 0.16, 0.29) depending on cohort. Our findings are consistent with the interpretation that parents pass on advantages to offspring not only via direct genetic transmission or purely environmental paths, but also via genetic associations with parental investment from conception to wealth inheritance.
Repurposing and computational design of PARP inhibitors as SARS-CoV-2 inhibitors
Authors: Rampogu Shailima , Jung Tae Sung , Ha Min Woo , Lee Keun Woo 
Published: June 2023

AbstractCoronavirus disease 2019 (COVID-19) is a recent pandemic that caused serious global emergency. To identify new and effective therapeutics, we employed a drug repurposing approach. The poly (ADP ribose) polymerase inhibitors were used for this purpose and were repurposed against the main protease (Mpro) target of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). The results from these studies were used to design compounds using the ‘Grow Scaffold’ modules available on Discovery Studio v2018. The three designed compounds, olaparib 1826 and olaparib 1885, and rucaparib 184 demonstrated better CDOCKER docking scores for Mpro than their parent compounds. Moreover, the compounds adhered to Lipinski’s rule of five and demonstrated a synthetic accessibility score of 3.55, 3.63, and 4.30 for olaparib 1826, olaparib 1885, and rucaparib 184, respectively. The short-range Coulombic and Lennard-Jones potentials also support the potential binding of the modified compounds to Mpro. Therefore, we propose these three compounds as novel SARS-CoV-2 inhibitors.
Exogenous AMPA downregulates gamma-frequency network oscillation in CA3 of rat hippocampal slices
Authors: Li Chengzhang , Li Zhenrong , Xu Sihan , Jiang Sanwei , Ye Zhenli , Yu Bin , Gong Shixiang , Li Junmei , Hu Qilin , Feng Bingyan , Wang Mengmeng , Lu Chengbiao 
Published: June 2023

AbstractPharmacologically-induced persistent hippocampal γ oscillation in area CA3 requires activation of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs). However, we demonstrated that exogenous AMPA dose-dependently inhibited carbachol (CCH)-induced γ oscillation in the CA3 area of rat hippocampal slices, but the underlying mechanism is not clear. Application of AMPARs antagonist NBQX (1 μM) did not affect γ oscillation power (γ power), nor AMPA-mediated γ power reduction. At 3 μM, NBQX had no effect on γ power but largely blocked AMPA-mediated γ power reduction. Ca2+-permeable AMPA receptor (CP-AMPAR) antagonist IEM1460 or CaMKK inhibitor STO-609 but not CaMKIIα inhibitor KN93 enhanced γ power, indicating that activation of CP-AMPAR or CaMKK negatively modulated CCH-induced γ oscillation. Either CP-AMPAR antagonist or CaMKK inhibitor alone did not affected AMPA-mediated γ power reduction, but co-administration of IEM1460 and NBQX (1 μM) largely prevented AMPA-mediated downregulation of γ suggesting that CP-AMPARs and CI-AMPARs are involved in AMPA downregulation of γ oscillation. The recurrent excitation recorded at CA3 stratum pyramidale was significantly reduced by AMPA application. Our results indicate that AMPA downregulation of γ oscillation may be related to the reduced recurrent excitation within CA3 local neuronal network due to rapid CI-AMPAR and CP-AMPAR activation.