bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Structural, Electrical and Dielectric Studies of CMC Based Biopolymer Gel Electrolytes for Ecofriendly Device Applications
Authors: Singh C. P. , Shukla P. K. , Singh Shubham , Agrawal S. L. , Srivastava Anshuman , Asthana Nidhi , Mishra Ajay Kumar 
Published: January 2025

ABSTRACTThe solution casting procedure has been effectively used to synthesize biopolymer gel electrolytes (BGEs) using carboxymethyl cellulose (CMC) and ammonium thiocyanate (NH4SCN). The XRD patterns of the bio‐based green emulsions (BGEs) have provided evidence of the non‐crystalline structure of the films. Optical micrographs of BGEs have revealed the formation of homogeneous gel electrolyte films. Complex impedance spectroscopy has been used to investigate the ion transport mechanism and dielectric relaxation dynamics of biopolymer gel electrolyte films over a wide range of temperatures. The conductivity of the gel electrolyte samples has been shown to rise with the amount of salt present. The optimum ionic conductivity, determined at room temperature, is σ = 3.97 × 10−3 Scm−1, and it is achieved in the gel electrolyte sample containing 35 wt% NH4SCN. The variation in ionic conductivity with temperature has shown a blend of Arrhenius and Vogel‐Tamman‐Fulcher (VTF) characteristics. An analysis has been conducted on the impedance data to investigate the ion transport process using the formalisms of ac conductivity, permittivity, and electric modulus. The dielectric impedance of the BGEs films has been used to determine the charge carrier density and mobility. The electrolyte with the best conductivity has shown a broad range of electrochemical stability, spanning from −1.49 to +1.27 V. The I‐t investigations has shown a high transference number (tion ~ 0.99), indicating that ions are the primary contributors to conductivity. The cyclic voltammetry tests have shown excellent reusability, indicating its potential use in devices, such as supercapacitors and rechargeable batteries.
Photoredox/Sulfide Dual Catalysis for Modular Synthesis of Multi‐substituted Furan Rings via Catalytic Indirect Reductive Quenching
Authors: Matsukuma Kakeru , Tayu Masanori , Ogino Takumi , Ohrui Sayaka , Noji Masahiro , Hayashi Satoshi , Saito Nozomi 
Published: January 2025

AbstractThe catalytic indirect reductive quenching method is facilitated by a combination of Ir(III) photoredox and sulfide dual‐catalysis system. This study demonstrated a method for synthesizing multi‐substituted furans by using a photoredox/sulfide dual‐catalysis system. This method enables the synthesis of various furan derivatives, including spirofurans and phthalans. The utility of this system was demonstrated through gram‐scale synthesis of the pharmaceutical molecule talopram. Mechanistic studies and density functional theory calculations suggested the formation of sulfonium species via sulfide radical cations, followed by intramolecular cyclization to produce the desired furan derivatives.
Economic assessment and process design to valorize citrus juice industry waste
Authors: Marchette Isabela Rosa , Cavallari Renata Beatriz Calegari , Rothier Fernanda do Canto , Bojorge Ninoska Isabel Bojorge Ramirez , Alhadeff Eliana M. , Young André Ferreira , dos Santos Brunno Ferreira 
Published: January 2025

AbstractThis study examines a biorefinery in an orange‐juice processing plant that uses sweet orange peels to produce biofuel, food additives, and essential oils. The simulation was run in Aspen Plus v12.1 and scaled using a rigorous economic analysis model. The study proves that biorefinery processes can transform the orange juice industry's organic waste into valuable products. Specifically, the proposed plant can produce 12.2 tons of 99.8% w/w ethanol and 25.8 t h‐1 of pectin from a flow rate of 381.6 t h‐1 of wet biomass. Using a sensitivity analysis tool, the optimal conditions for limonene extraction were identified as a temperature of 90 °C and a pressure of 0.68 atm, resulting in a production rate of 5.9 t h‐1 (97% w/w), This achieved a limonene recovery of 99.6% w/w per dry mass of biomass. Finally, this study provides insights into the potential for sustainable resource use in the orange juice sector.
Students' sense of belonging and authenticity in higher education
Authors: Verbree Anne‐Roos , van der Schaaf Marieke , Wijngaards‐de Meij Leoniek , Dilaver Gönül 
Published: January 2025

AbstractSense of belonging entails students' comfort level in the classroom and experienced faculty and peer support. A diminished sense of belonging can hamper academic performance. Therefore, it is important to know which student groups may experience weaker belonging and whether these disparities extend to students' authenticity, or perception they can be true to themselves. This survey research examines student differences in sense of belonging and authenticity by gender, sexual orientation, ethnicity, religion, disabilities, extracurricular involvement, parental education, prior education, study year and school. We also examined whether belonging and authenticity were related to students' self‐reported academic performance. Our sample (N = 4473) consisted of Dutch undergraduate and graduate students. Data analysis employing structural equation modelling showed that male students felt more comfortable in the classroom and students with disabilities experienced less sense of belonging and authenticity than their peers. Extracurricular involvement enhanced students' belonging and authenticity. Being part of multiple minority groups impaired aspects of students' belonging and authenticity. Sense of belonging and the experienced room for authenticity positively and independently predicted academic performance. We conclude that fostering both belonging and authenticity is crucial for all students, but especially for minority students. We suggest educators foster students' sense of belonging and authenticity, which can enhance academic performance and promote educational equality and opportunities for all students. Stimulating extracurricular involvement or others forms of non‐academic participation is promising to contribute to this goal.
Evaluating Circular Strategies for the Resilience of Agri‐Food Business: Evidence From the Olive Oil Supply Chain
Authors: Spada E. , Carlucci D. , Cembalo L. , Chinnici G. , D'Amico M. , Falcone G. , Giannoccaro G. , Gulisano G. , Iofrida N. , Stempfle S. , De Luca A. I. 
Published: January 2025

ABSTRACTIn the agri‐food sector, the valorization of by‐products according to a circular economy (CE) approach can be a viable solution to increase profits and improve business resilience. However, to facilitate its implementation and dissemination, it is necessary to validate the application of CE approaches in real case studies and as well as to verify their economic sustainability. This paper analyses the adoption of different circular paths of real case studies in the olive oil supply chain and assesses their degree of circularity through the Material Circularity Indicator (MCI) and economic sustainability through life cycle costing (LCC). As evidenced in the scientific literature, these methodologies represent the optimal approach to assess the impact of circularity in agri‐food processes on companies' sustainability strategies. Moreover, the results can be integrated to facilitate progress toward ever‐greater sustainability. Findings show that the degree of circularity varies according to the different strategies adopted, highlighting better economic viability of firms that adopt CE strategies, whose profits are less sensitive to changes in input and output prices and therefore more resilient from an economic point of view when market fluctuations occur.
Exploring Multiplex Immunohistochemistry (mIHC) Techniques and Histopathology Image Analysis: Current Practice and Potential for Clinical Incorporation
Authors: Sun Aria Kaiyuan , Fan Song , Choi Siu Wai 
Published: January 2025

ABSTRACTBackgroundBy simultaneously staining multiple immunomarkers on a single tissue section, multiplexed immunohistochemistry (mIHC) enhances the amount of information that can be observed in a single tissue section and thus can be a powerful tool to visualise cellular interactions directly in the tumour microenvironment. Performing mIHC remains technically and practically challenging, and this technique has many limitations if not properly validated. However, with proper validation, heterogeneity between histopathological images can be avoided.AimsThis review aimed to summarize the currently used methods and to propose a standardised method for effective mIHC.Materials and MethodsAn extensive literature review was conducted to identify different methods currently in use for mIHC.ResultsGuidelines for antibody selection, panel design, antibody validation and analytical strategies are given. The advantages and disadvantages of each method are discussed.ConclusionThis review summarizes widely used pathology imaging software and discusses the potential for automation of pathology image analysis so that mIHC technology can be a truly powerful tool for research as well as clinical use.
The Association Between Body Composition, Overall Survival, Treatment Decisions, and Patient‐Reported Outcomes in Metastatic Non‐Small‐Cell Lung Cancer
Authors: Coletta Adriana M. , Lee Hyejung , Puri Sonam , Culleton Sinead , Covington Matthew F. , Yap Jeffrey T. , Maslana Kelsey E. , Haaland Benjamin , Akerley Wallace 
Published: January 2025

ABSTRACTIntroductionThe purpose of this study was to evaluate the association between body composition, overall survival, odds of receiving treatment, and patient‐reported outcomes (PROs) in individuals living with metastatic non‐small‐cell lung cancer (mNSCLC).MethodsThis retrospective analysis was conducted in newly diagnosed patients with mNSCLC who had computed‐tomography (CT) scans and completed PRO questionnaires close to metastatic diagnosis date. Cox proportional hazard models and logistic regression evaluated overall survival and odds of receiving treatment, respectively. Hazard ratios (HR) and odds ratios (OR) were evaluated as the interquartile range for body composition compartments. Multiple linear regression evaluated the association between PROs and body composition. Models were adjusted for gender, age at diagnosis, smoking history, and mutation status. The survival model also included adjustment for tumor histology.ResultsOur sample (n = 69) included men (52%) and women (48%), with a median age of 67.4‐years, history of smoking (67%), wild‐type genotype (75.4%), and a tumor histology of adenocarcinoma (68%). Greater skeletal muscle area was associated with higher physical function scores. Larger intermuscular adipose tissue area was associated with higher mortality risk (HR 2.03, 95% CI 1.32, 3.11), lower odds of receiving treatment (OR 0.76, 95% CI 0.61, 0.93), and higher fatigue. Larger subcutaneous adipose tissue area was associated with lower mortality risk (HR 0.42, 95% CI 0.22, 0.82) and higher odds of receiving treatment (OR 1.03, 95% CI 1.01, 1.06). Larger total adipose tissue area was linked with improved survival (HR 0.59, 95% CI 0.36, 0.96).ConclusionFindings support an association between different body composition compartments at mNSCLC diagnosis and survival, decisions to treat, and PROs. This work supports the use of data collected in routine CT scans and PROs to inform treatment decisions and supportive care options.
Differentiating Pulmonary Nodule Malignancy Using Exhaled Volatile Organic Compounds: A Prospective Observational Study
Authors: Lu Guangyu , Su Zhixia , Yu Xiaoping , He Yuhang , Sha Taining , Yan Kai , Guo Hong , Tao Yujian , Liao Liting , Zhang Yanyan , Lu Guotao , Gong Weijuan 
Published: January 2025

ABSTRACTBackgroundAdvances in imaging technology have enhanced the detection of pulmonary nodules. However, determining malignancy often requires invasive procedures or repeated radiation exposure, underscoring the need for safer, noninvasive diagnostic alternatives. Analyzing exhaled volatile organic compounds (VOCs) shows promise, yet its effectiveness in assessing the malignancy of pulmonary nodules remains underexplored.MethodsEmploying a prospective study design from June 2023 to January 2024 at the Affiliated Hospital of Yangzhou University, we assessed the malignancy of pulmonary nodules using the Mayo Clinic model and collected exhaled breath samples alongside lifestyle and health examination data. We applied five machine learning (ML) algorithms to develop predictive models which were evaluated using area under the curve (AUC), sensitivity, specificity, and other relevant metrics.ResultsA total of 267 participants were enrolled, including 210 with low‐risk and 57 with moderate‐risk pulmonary nodules. Univariate analysis identified 11 exhaled VOCs associated with nodule malignancy, alongside two lifestyle factors (smoke index and sites of tobacco smoke inhalation) and one clinical metric (nodule diameter) as independent predictors for moderate‐risk nodules. The logistic regression model integrating lifestyle and health data achieved an AUC of 0.91 (95% CI: 0.8611–0.9658), while the random forest model incorporating exhaled VOCs achieved an AUC of 0.99 (95% CI: 0.974–1.00). Calibration curves indicated strong concordance between predicted and observed risks. Decision curve analysis confirmed the net benefit of these models over traditional methods. A nomogram was developed to aid clinicians in assessing nodule malignancy based on VOCs, lifestyle, and health data.ConclusionsThe integration of ML algorithms with exhaled biomarkers and clinical data provides a robust framework for noninvasive assessment of pulmonary nodules. These models offer a safer alternative to traditional methods and may enhance early detection and management of pulmonary nodules. Further validation through larger, multicenter studies is necessary to establish their generalizability.Trial Registration: Number ChiCTR2400081283
Three Novel Quinoline Alkaloids From Tetradium glabrifolium and Their Antibacterial Activities
Authors: Luo Li‐li , Chen Jun‐lei , Du Cai‐xia , Huang Lie‐jun , Yuan Chun‐mao , Yang Jue , Hu Zhan‐Xing , Hao Xiao‐jiang , Gu Wei 
Published: January 2025

ABSTRACTThree novel quinoline alkaloids, tetradiunitiside A (1), tetradiunitiside B (2), and glycohaplopine‐6‐O‐α‐l‐rhamnopyranoside (3), along with eight known ones (4–11), were isolated from the fruits of Tetradium glabrifolium. Their structures were inferred by IR, 1D NMR and 2D NMR, and HR–ESI–MS spectra. All the isolated compounds were evaluated for their antibacterial activities. Compounds 1–11 had potential antibacterial activities against Bacillus gasoformans, Bacillus subtilis, Pseudomonas solanacearum, and Pseudomonas aeruginosa, with minimum inhibitory concentration (MIC) values ranging from 100 to 3.125 µg/mL. Among them, compound 6 showed the most significant antibacterial activity against four strains of bacteria. These findings elucidated the pharmacological substance basis for the antibacterial activity of T. glabrifolium to some extent.
Construction of Double‐layered DNA Tiles and Arrays from Double Crossover Motifs
Authors: Wang Ruoran , Wang Yu , Lu Biao , Zhang Wei , Xia Bing , Xiao Shou‐Jun 
Published: January 2025

AbstractDNA double crossover (DX) motifs including DAE (double crossover, antiparallel, even spacing) and DAO (double crossover, antiparallel, odd spacing) are well‐known monolayered DNA building blocks for construction of 2D DNA arrays and tubes in nanoscale and microscale. Compared to the 3D architectures of DNA origami and single‐stranded DNA bricks to build nanoscale 3D bundles, tessellations, gears, castles, etc., designs of double‐ and multi‐layers of DX motifs for 3D architectures are still limited. Herein, we report two types of double‐layered tiles derived from DAE motifs with single‐stranded circular 42‐ and 64‐nt oligonucleotides as scaffold strands. Further tiling of the tiles generated planar 3D crystalline domains and curved tubes, correspondingly. Finally, we applied the chiral index theory to derive the unit tube parameters of six E‐tiling (inter‐tile distance of even spacing) tubes and analyzed the causation of difference between these tubes.
Double Outlet Right Ventricle: A Rare Finding in a 15‐Month‐Old Female With Failure to Thrive
Authors: Pedun Bernadette , Pitua Ivaan , Bongomin Felix , Bugeza Samuel , Luzinda Rita Nassanga 
Published: January 2025

ABSTRACTDouble outlet right ventricle (DORV) is a rare congenital heart defect where both the aorta and pulmonary artery originate from the right ventricle, often accompanied by additional cardiac anomalies to mitigate circulatory imbalance, though such compensations usually fail. We report a 15‐month‐old infant with recurrent respiratory infections and poor weight gain, referred for computed tomography angiography. Physical examination showed a small, non‐syndromic infant with pallor, tachypnea, irritability, and finger clubbing. Initial imaging revealed cardiomegaly and lung infiltrates; echocardiography and computed tomography angiography confirmed additional intracardiac defects of double superior vena cavae, a hypoplastic aortic arch, hypertrophic right ventricular wall, and a patent ductus arteriosus. Corrective surgery was delayed due to respiratory complications. This case emphasizes the critical need to consider cardiac pathology in pediatric patients with recurrent respiratory symptoms, as untreated DORV can lead to high mortality.
Unsafe Care and Fake News in Freeman–Burian Syndrome
Authors: Poling Mikaela I. , Dufresne Craig R. 
Published: January 2025

ABSTRACTFreeman‐Burian syndrome is a rare craniofacial syndrome surrounded by fake news. This situation shows the strong connection between the quality of a literature search and clinical reasoning displayed in patient care, especially in care of patients with rare conditions.
Construction of Co3O4/Pt Catalyst with Interfacial N‐Stabilized Co3+‐OH‐Pt Pair for Highly Efficient CO2 Methanation
Authors: Li Jingru , Hu Siyuan , Shang Longmei , Zhan Guowu 
Published: January 2025

AbstractCO2 hydrogenation is a promising method for converting CO2 into valuable products. Cobalt‐based catalysts are favored for their low cost and high activity, but they face challenges from sintering‐induced deactivation. This study investigates N‐doped Co3O4/Pt catalysts synthesized using a Pt‐decorated ZIF‐67 sacrificial template, followed by a water‐soaking treatment to enhance surface hydroxyl (─OH) group content. The as‐designed N‐Co3O4/Pt catalyst achieved a CO2 conversion of 64% and CH4 selectivity of 98% at 340 °C under ambient pressure. It was demonstrated that the interfacial N‐stabilized Co3+‐OH‐Pt active sites in N‐Co3O4/Pt improved synergy between cobalt and platinum, enhancing agglomeration resistance and enhancing catalytic performance. In situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) demonstrated that CO2 is converted to methane mainly through a formic acid pathway, with no CO detected. This work underscores the critical role of surface hydroxyl groups in promoting CO2 adsorption and activation, guiding the CO2 methanation reaction toward efficient methane production.
Three‐Dimensional Fluid Flow Over an Elastic Sheet Stretched Nonlinearly in Two Lateral Directions
Authors: Manoharkumar K. N. , Patil Shalini M. , P.A. Dinesh 
Published: January 2025

AbstractPresent research work explores the three‐dimensional nanofluid flow across a horizontal surface with bi‐directional deviation of velocity in power‐law index n. Porosity, the ohmic effect with other parameters, thermophoresis, Prandtl number, Schmidt number, and Brownian motion in the flow geometry are taken into consideration. Dimensional nonlinear formulations are changed into dimensionless expressions by employing the appropriate similarity transformation. Utilizing shooting procedure and the fourth‐fifth‐order Runge–Kutta integration approach, the numerical result has been achieved, and velocity, temperature, and concentration profiles are presented through graphs to illustrate the findings. The current outcome has numerous industrial applications, including the production of paper, metal extrusion, and optical fiber. The major findings of the present research are good agreement compared to the data that are accessible in the limiting instance compared with the earlier results.
Modulating structural oxygen/crystallinity enables ambient cascade photo‐upgrading of biomass saccharides to lactic acid
Authors: Huang Jinshu , Ding Yan , Li Jie , Hu Zhao , Saravanamurugan Shunmugavel , Wang Junqi , Su Yaqiong , Yang Song , Li Hu 
Published: January 2025

AbstractPhotocatalytic transformation of biomass into biofuels and value‐added chemicals is of great significance for carbon neutrality. Metal‐free carbon nitride has extensive applications but with almost no absorption and utilization of near‐infrared light, accounting for 50% of sunlight. Here, a molten salt‐assisted in‐plane “stitching” and interlayer “cutting” protocol is developed for constructing a highly crystalline carbon nitride catalyst containing structural oxygen (HC‐CN). HC‐CN is highly efficient for the photothermal cascade transformation of biomass‐derived glucose into lactic acid (LA) with an unprecedented yield (94.3%) at 25°C under full‐spectrum light irradiation within 50 min, which is also applicable to quantitatively photo‐upgrading various saccharides. Theoretical calculations expound that the light‐induced glucose‐to‐catalyst charge transfer can activate the Cβ–H bond to promote the rate‐determining step of intramolecular hydrogen shift in glucose‐to‐fructose isomerization. Meanwhile, the introduced structural oxygen in HC‐CN can not only facilitate the local electric field formation to achieve rapid charge transport/separation and regulate selective •O2− generation for oriented C3–C4 bond cleavage of fructose but also narrow the energy band gap to broaden the light absorption range of HC‐CN, contributing to enhanced LA production without exogenous heating. Moreover, HC‐CN is highly recyclable and exhibits negligible environmental burden and low energy consumption, as disclosed by the life cycle assessment. Tailored construction of full‐spectrum light adsorption and versatile reaction sites provides a reference for implementing multi‐step biomass and organic conversion processes under mild conditions.
One Step Synthesis of 4,6,8‐Trimethoxyazulenes ‐ as Building Block for 2‐Functionalized Azulenes
Authors: Wunsch Jonas F. , Sommer Hendrick M. , Kohl Senta J. , Maier Rouven , Rudolph Matthias , Rominger Frank , Hashmi A. Stephen K. 
Published: January 2025

AbstractHere we present a simple gold‐catalyzed one‐pot reaction of easily available diarylbutadiynes, with trimethoxybenzene as solvent and reactant to synthesize 4,6,8‐trimethoxyazulenes. The methoxy substituents, which render the azulene very electron‐rich, enable a change of azulenes typical regioselectivity for electrophilic substitutions, which enables facile electrophilic 2‐substitution with iodine, bromine, chlorine, selenium or sulfur. Especially the 2‐haloazulenes which can usually only be obtained through lengthy multistep syntheses are valuable building blocks for the synthesis of 2‐substituted azulene derivatives.