bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technology Focus: Extended-Reach and Complex Wells (May 2023)
Authors: Qiu Kaibin 
Published: June 2023

A clear change in the last 2–3 years is that the energy transition is becoming the undisputable trend for almost all major oil and gas companies and oilfield services providers, as evident from the news of rebranding, the roll-out of companies’ new strategies, and announcements of commitments to net zero. Geothermal energy, especially within deep, hot, dry rock, is abundant around the globe. It can be a great opportunity for the majors to boost their energy-transition process and open new business opportunities.
Previously, however, deep geothermal development activities were rather limited and participation from the majors was sporadic. One reason was that drilling into such extra-hot and extra-deep impermeable rock could render excessively high cost and risk, making the development of deep geothermal energy far from economical and scalable and discouraging many companies from entering this hot spot.
The domain expertise and technologies in the oil and gas industry such as integrated project planning and operating, extended-reach drilling (ERD), high-pressure/high-temperature drilling tools, multilateral drilling and completions, geomechanics, flow and thermal dynamics modeling, and artificial intelligence have been fueling the ongoing march for new records on ERD, multilateral, and other complex wells. They have made it possible to drill faster, further, and with more production, which will be the keys to accelerating the learning curve, filling the technology gap, and breaking the economic barrier on deep geothermal drilling, which in turn will attract more players to this new arena.
A bold move of the majors into deep geothermal drilling could accelerate the removal of the economic and technical hurdles in harnessing the enormous baseload renewable energy and meanwhile backfeed new drilling technologies developed in deep geothermal applications to the oil and gas industry for a more sustainable future.
Recommended additional reading at OnePetro: www.onepetro.org.
SPE 206616 Deep Geothermal Well-Construction Problems and Possible Solutions by Mikhail Yakovlevich Gelfgat, Gubkin University, et al.
SPE 200792 Lessons Learned and Case Studies of Overcoming Sustained Casing Pressure in Extended-Reach Wells by Svetlana Nafikova, SLB, et al.
IPTC 21439 Application of Multilateral Wells for Production and Enhanced Oil Recovery: Case Studies From Canada by Eric Delamaide, IFP-Technologies
Expertise in Complex-Well Construction Leveraged for Geothermal Wells
Authors: Carpenter Chris 
Published: June 2023

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This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 204097, “Constructing Deep Closed-Loop Geothermal Wells for Globally Scalable Energy Production by Leveraging Oil and Gas Extended-Reach Drilling and High-Pressure/High-Temperature Well-Construction Expertise,” by Eric van Oort, SPE, Dongmei Chen, SPE, and Pradeepkumar Ashok, SPE, The University of Texas at Austin, et al. The paper has not been peer reviewed.

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In the complete paper, deep closed-loop geothermal systems (DCLGS) are introduced as an alternative to traditional enhanced geothermal systems (EGS) for green energy production that is globally scalable and dispatchable. The authors demonstrate that DCLGS wells can generate power on a scale comparable to that of EGS. They also highlight technology gaps and needs that still exist for economically drilling DCLGS wells, writing that it is possible to extend oil and gas technology, expertise, and experience in extended-reach drilling (ERD) and high-pressure/high-temperature (HP/HT) drilling to construct complex DCLGS wells.

Introduction
CLGS is considered a subset of EGS, but the authors write that it is a distinct entity. EGS mostly involves well designs that rely on fractures for heat extraction. Such systems are different from CLGS wells in that the latter use closed conduits for thermal fluid circulation and heating. CLGS relies on fluids pumped through a closed loop. The authors treat CLGS systems as being different from EGS systems, with the understanding that drilling technologies discussed in the paper as enablers for CLGS wells apply equally to EGS wells.
In the geothermal (GT) domain, the majority of attention and funding currently is assigned to EGS projects. A case is made in the complete paper to continue to develop DCLGS technology because of its favorable risk profile compared with EGS.
Part I of the complete paper introduces a hydraulic model coupled with a thermal model suitable for calculating the power generation of DCLGS wells. This synopsis concentrates instead on Part II of the complete paper, in which technology gaps and needs of DCLGS drilling and well construction are highlighted and opportunities identified where oil and gas experience and technology can be directly applied and leveraged.

Similarities and Differences of Deep GT and Oil and Gas HP/HT Wells
- GT wells generally use larger production hole sizes than typical land wells.
- Casing-cement annuli typically are cemented back to surface.
- GT wells can be drilled in more-forgiving pore-pressure fracture gradient (PPFG) environments with wider drilling margins than geopressured HP/HT wells in hydrocarbon systems.
- Severe lost circulation appears to be a universal problem in deep GT wells.
- Drilling costs can account for 50% or more of the total capital costs for a GT energy project.
- Data sets on GT wells are much smaller than those for oil and gas wells.
Study Compares Methods To Measure Static Gel-Strength Development
Authors: Carpenter Chris 
Published: June 2023

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This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper OTC 31348, “Comparing Oilwell Cement Static Gel-Strength Development by Ultrasonic and Intermittent- and Continuous-Rotation Measurement Methods,” by Shameed Ashraf, Rahmad H.M. Husin, and Awang Rizalman, Schlumberger, et al. The paper has not been peer reviewed. Copyright 2022 Offshore Technology Conference. Reproduced by permission.

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Cement-sheath integrity preventing interzonal communication is closely related to static gel strength (SGS). API Standard 65-2 puts importance on the critical gel strength period (CGSP) measurement, which begins when the critical static gel strength (CSGS) is developed and ends when 500 lbf/100 ft2 is attained. The three methods accepted in the industry to measure SGS development are continuous and intermittent rotation, followed by ultrasonic measurement. A laboratory-based study is presented in the complete paper that compares these measurement methods.

SGS Measurement Methods
Continuous-Rotation Device. The continuous-rotation device used for direct SGS measurement is equipped with a pressure vessel capable of maintaining the set temperature and pressure that simulates actual cementing conditions. The paddle drag created by the continuous movement is converted and measured as SGS by means of correlation.
Intermittent-Rotation SGS Device. This device keeps the cement slurry to be evaluated in a static condition inside a pressure vessel at controlled temperature and pressure. The device features a torque-sensing arrangement that obtains the intermittent rotating paddle value. This measured torque value is used to calculate the SGS using correlations related to paddle dimensions.
Ultrasonic Method. An ultrasonic device can estimate the SGS of a concrete slurry under high-pressure and high-temperature conditions using an acoustic ultrasonic mechanism based on the attenuation of the acoustic wave communicated through the slurry during the hydration process. The ultrasonic cement-analyzer configuration estimates the acoustic speed, whereas the SGS analyzer measures the signal through the slurry. Thus, the SGS analyzer joins an implanted framework that performs computerized gel analysis. When data collection is complete, investigation of the information calculates the SGS values as a function of time. The authors compared the results obtained by this SGS system with information acquired from the tube rheometer device and shearometer and found them to have similar findings.

Testing Methodology
The methodology included the cement-slurry formula and the preparations followed by the device settings for each assessment type. Two different paddle configurations are used for the continuous-rotation method. As a result, four types of equipment evaluation are made for each slurry, two for the continuous-rotation type, one for the intermittent-rotation type, and one for the ultrasonic type.
Evaluating the Effectiveness of Daily Self-Weighing to Prevent Age-Related Weight Gain
Authors: Levitsky David , Zhong Yingyi , Barre Laura , Mizia Alyse 
Published: June 2023

Abstract
Objective
Age-related weight gain refers to the gain in adult body weight with age. What makes age-related weight gain a serious public health problem is that the higher the rate of age-related weight gain, the greater the incidence of many weight related diseases such as diabetes, hypertension and heart disease. We examined the efficacy of daily self-weighing to reduce age-related weight gain among university employees.
Design:
Participants were randomized into two groups. One group (experimental) were given internet-based scales and asked to weigh themselves daily. They received an email reminder if more than three days elapsed between weighings. The other group (control), like the experimental group, was weighed at the beginning and the end of the two-year experimental period.
Settings:
The initial and final weighing occurred in the Metabolic Unit of the Division of Nutritional Sciences, Cornell University, Ithaca, NY.
Participants:
The participants were 286 adult employees of a Cornell University
Results
Using the conventional Intent-to-Treat analysis neither the within subject weight change over time (-0.38kg [-1.27kg, 0.50kg], control: 0.19kg [-0.56kg, 0.93kg]) nor the between groups (0.40kg, p = 0.183) reached statistical significance. However, when the non-compliers from both the experimental and control group were removed, the self-weighers gained significantly less weight than the controls (0.59 kg (p = 0.048)). Analyses controlled for baseline weight, gender, ethnicity, age, education, marital status, weight change the year before the study, and baseline weighing frequency.
Conclusion
Compliers to daily self-weighing gained significantly less weight over two years than a matched group who did not self-weigh.
Process Modularity Impact on Manufacturing Lead Time and Throughput Rate in Terms of Mass Customization
Authors: Modrak Vladimir , Soltysova Zuzana , Nazarejova Julia 
Published: June 2023

Abstract
As mass customization becomes more pervasive in many sectors, researcher needs to update traditional approaches to optimization of critical performance and design parameters in order to help companies in their effort to implement this strategy. In general, implementation of mass customization from manufacturing perspective is frequently focused on shortening cycle times, reducing production cost, and increasing throughput rate of parts. In this paper, process structure modularity impact on manufacturing lead times and throughput rates is explored. An important precondition to explore these relationships is awareness that process modularity is conceptualized and quantified in an appropriate way. For this purpose, two independent modularity measures were employed to provide more reliable assessment of this system property. The relationships were investigated on the basis of simulation experiments using deterministic models of alternative process structures. The results from the experiments showed that there are strong correlations between process modularity and manufacturing lead time, as well as between process modularity and throughput rate.
Skin-effect-mediated magnetoionic control of charge transport in thick layers
Authors: Mohseni S.Majid , Miandoab Vahid Barough , Jamilpanah loghman , Zare Mohammad , Ghanaatshoar Majid 
Published: June 2023

Abstract
In the rapidly developing area of magnetoionics (MI), which combines electrochemistry and magnetism, changes in the surface chemistry of magnetic materials in response to gate voltages cause dramatic modifications in the magnetic characteristics, resulting in low power-consuming charge transport tuning. Due to the surficial character, only magnetic thin films have been addressed for the MI effect's role in controlling charge transfer. Here, we show how it can be used to regulate the transit of charges in bulk magnetic materials. This is accomplished by combining high-permeability magnetic materials with a high-frequency passing current, allowing the skin effect and the MI effect to control the magnetic materials' impedance due to the impedance's high sensitivity to magnetic permeability. Our in-situ impedance measurement and magneto-optical characterization show the role of redox reactions at the surface in controlling impedance in magnetic materials. This research paves the way for using the MI effect in high permeability bulk magnetic materials.
NDUFS4 Regulates Cristae Remodeling in Diabetic Kidney Disease
Authors: Danesh Farhad , Mise Koki , Long Jianyin , Galvan Daniel , Ye Zengchun , Fan Guizhen , Serysheva Irina , Moore Travis , Wada Jun , Schumacker Paul , Chang Benny 
Published: June 2023

Abstract
The mitochondrial electron transport chain (ETC) is a highly adaptive process to meet metabolic demands of the cell, and its dysregulation has been associated with diverse clinical pathologies. However, the role and nature of impaired ETC in kidney diseases remains poorly understood. Here, we generated diabetic mice with podocyte-specific overexpression of Ndufs4, an accessory subunit of mitochondrial complex I, as a model to investigate the role of ETC integrity in diabetic kidney disease (DKD). We find that these conditional mice exhibit significant improvements in cristae morphology, mitochondrial dynamics, and albuminuria. By coupling proximity labeling with super-resolution imaging, we also identify the role of cristae shaping proteins in linking NDUFS4 with improved cristae morphology. Taken together, we discover the central role of NDUFS4 as a powerful regulator of cristae remodeling, respiratory supercomplexes assembly, and mitochondrial ultrastructure in vitro and in vivo. We propose that targeting NDUFS4 represents a promising approach to slow the progression of DKD.
Seasonality and association with climate factors of peritonsillar, retropharyngeal, and parapharyngeal abscesses in Korea
Authors: Kim Su Il , Lee Hun Hee , Eun Young-Gyu , Lee Young Chan 
Published: June 2023

Abstract
Background
Deep neck space abscesses are an important medical problem but the extent of their seasonality is not yet fully understood. Thus, we aimed to examine the seasonality of deep neck space abscesses and define the associated climate factors using a nationwide, population-based, cross‐sectional data.
Methods
Korean National Health Insurance-derived database with records from January 2010 to December 2019 was utilized in this study. We identified patients with peritonsillar, retropharyngeal, and parapharyngeal abscesses who were assigned the following diagnostic codes as a principal or first additional diagnosis: The International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) codes J36 (peritonsillar abscess), J39.0, and J39.1 (retropharyngeal and parapharyngeal abscess and other abscess of the pharynx). We calculated the seasonal ratio as the ratio of the highest to the lowest number of patients per each month to assess the degree of seasonality for each studied condition. In addition, climate data points corresponding to each month were obtained. Thus, we analyzed correlations between the monthly patient numbers for each disease and various climate-related factors.
Results
We detected seasonal variations in the number of peritonsillar, retropharyngeal, and parapharyngeal abscesses, which were highest in winter-to-spring and lowest in summer. Peritonsillar abscesses were strongly correlated with average temperature, ground temperature, relative humidity, precipitation, daily temperature range, and particulate matter < 10µm (PM10). Retropharyngeal and parapharyngeal abscesses were linked to similar climate factors but with sunlight rate instead of PM10.
Conclusion
This large population-based study highlights a clear seasonality and climate relevance in patients with deep neck space abscesses. Further studies exploring detailed demographic factors associated with the incidence of deep neck space abscesses are required to better characterize these conditions.
Physicochemical Profile of Non-polar Extracts of Colombian Propolis (Npcs) and Their Correlation With the Antimicrobial Activity of Pathogenic Strains
Authors: Márquez David Guillermo Piedrahita , Ovalle Lady Viviana Camargo , Maraschin Marcelo , Schmitz Caroline , Díaz-Moreno Consuelo , Suárez-Mahecha Héctor 
Published: June 2023

Abstract
Honeybees collect multiple types of propolis with high concentrations of bioactive compounds with notorious antimicrobial activity against gram-positive and gram-negative bacteria, undesirable microorganisms in food products. Propolis is produced by collecting and transforming plant exudates around hives. Their composition and action against pathogenic microorganisms vary according to the hive structure and the plant's chemical composition. In the literature, there is a lack of information on the Colombian propolis action against pathogens, and there is no information about the chemical profile of the compounds in these samples. Therefore, to identify propolis's chemical profile and correlate the metabolites with the antimicrobial action, it is necessary to perform a metabolomic analysis that integrates spectroscopic techniques and bioassays. Techniques such as GC-FID, NMR, and U-HPLC were used to obtain the profile and concentration of low molecular weight metabolites, amino acids, fatty acids, and polyphenols. Then, the extracts were analysed by minimum inhibitory concentration (MIC) tests to elucidate the bactericidal power of the extracts. It was concluded that the ecosystem and botanical species are the main characteristics that allow the discrimination of propolis. Additionally, it was seen that the bioactivity against pathogens was due to a synergistic effect between various metabolites, which have variations in their chemical structure, mainly in molecular weight and functional groups. Additionally, it was seen that the ecosystem has a more significant influence on the propolis composition compared to the bee species that collect the exudates.
The effect of m-Health interventions on early child development: a systematic review protocol
Authors: Tavassoli Ghanbar , Samimi Tahereh , Afshar Hadi Lotfnezhad , Eslamlou Hamidreza Farrokh , Rahimi Bahlol 
Published: June 2023

Abstract
Introduction Assisting in the growth and development of children can have an impact on the long-term sustainable progress of society. The integration of mobile health technology (m-health), which is a widely available and easily accessible approach, can be advantageous in achieving this goal. This protocol outlines a systematic review strategy for identifying articles that promote children's development through the use of m-health. Methods We developed this review protocol using the Systematic Review and Meta-Analysis Protocols (PRISMA-P) checklist. To conduct this systematic review, we will perform searches in PubMed, Scopus, and Web of Science databases. Our search strategy includes English articles published between 2000 and 2022, using Medical Subject Heading (MeSH) terms and related keywords. We will use the participants, interventions, comparators, and outcomes (PICO) framework to determine article inclusion criteria. At least two independent reviewers will assess the articles, and the findings will be reported in the published article. Discussion We expect that the results of this systematic review will clarify the effects of health on different aspects of child development and assist health policymakers in selecting cost-effective and optimal solutions to improve children's development across various domains. Additionally, it has the potential to identify gaps and provide directions for future research in this field. Systematic review registration: PROSPERO registration number is CRD42022339264
Discovery of a new anticancer nicotinamide analog that targets the VEGFR-2 enzyme: a computer-assisted drug design (CADD) story
Authors: Eissa Ibrahim H. , Bkrah Mohamed , Yousef Reda , Elkady Hazem , Elkaeed Eslam B. , Alsfouk Bshra A. , Ibrahim Ibrahim M. , Metwaly Ahmed M. , Husein Dalal Z. 
Published: June 2023

Abstract
A new nicotinamide derivative, (E)-N-(4-(1-(2-(4-Benzamidobenzoyl)hydrazono)ethyl)phenyl)nicotinamide, was designed and evaluated for its potential to inhibit VEGFR-2. Density functional theory (DFT) calculations were carried out to explore the stability and reactivity of the designed compound. The molecular docking assessments indicated its potential to inhibit VEGFR-2. The molecular dynamics (MD) simulations further confirmed the binding with VEGFR-2. MM-GBSA analysis, PLIP experiments, and essential dynamics studies authenticated the precise binding with optimal energy. Then the targeted compound was synthesized and named compound 10. In vitro assays showed that compound 10 inhibited VEGFR-2 with an IC50 value of 0.1174 µM and exhibited potent cytotoxic properties against HepG2 and MCF-7 cancer cell lines with IC50 value of 35.78 µM and 57.62, respectively. Intwestingly, compound 10 showed low toxicity against vero cell lines exhibiting an IC50 value of 127.3 µM. Furthermore, compound 10 induced apoptosis of HepG2 cell lines making a substantial increase of 2.61-fold in caspase-3 levels and 3.66-fold in caspase-9. Finally, compound 10 decreased the potentialities of HepG2 cells to migrate and heal significantly. The results of the in vitro assays were consistent with in silico results, indicating the efficacy and safety of compound 10. In conclusion, the computer-assisted drug design (CADD) approach used in this study provide compound 10 as a promising candidate for the development of a new lead anticancer drug.