bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Hubble parameter data and possibility of more than one deceleration–acceleration transition redshift
Authors: Salehi Amin , Hatami H. 
Published: December 2022

AbstractIt is quite believed that Universe has undergone a smooth transition from a decelerated phase to its present accelerated phase of expansion. There exists a wide consensus, based on robust observational indicating transition redshift $$z_{tr}$$

z

tr

around the unity. However our analysis on complete collection of reliable Hubble parameter H(z) data at intermediate redshift $$0.07<z <2.36 $$

0.07
<
z
<
2.36

, BAO, Pantheon data, give some hints that the universe may be transit more than one time from deceleration to acceleration phase in course of its evolution. Although we are agree with the results claimed by previous studies state the simplest cosmological models such as $$\Lambda CDM$$

Λ
C
D
M

and XCDM are consistent with Hubble data, but we doubt that they will be the best. We show that the chameleon cosmological model is more favored than the simple models and very well fits with the full Hubble data. Reconstructing the deceleration parameter based on best fitted parameters of the model indicates a new dynamic for the universe in which more than one transition occurs from deceleration to acceleration phase and the last transition occurs at $$z_{tr}\simeq .43\pm 0.04$$

z

tr

≃
.
43
±
0.04

which is close to that derived by the High-z Supernovae Search (HZSNS) team, $$z_{tr}=.43\pm 0.07$$

z

tr

=
.
43
±
0.07

(Riess et al. Astrophys. J. 659, 98–121, 2007).
Microleakage Evaluation of Two Methacrylate-Based Composites (GC Kalore and Luna SDI) in Class II Restorations: A Laboratory Study
Authors: Moradi Kooshan , Mahmoudinezhad Sadaf Sadat , Mapar Mehran 
Published: December 2022

Objective. In recent years, dental composite resins such as tooth-colored restoration are frequently used to restore dental cavities, coronal fractures, and congenital defects. This study aimed to evaluate the microleakage of two methacrylate-based composites (GC Kalore and Luna SDI) in class II restorations. Materials and Methods. In this experimental study, a total of 18 intact human premolars previously extracted for periodontal and orthodontic reasons were randomly divided into two groups. Similar class II cavities (box only) were prepared on all teeth and restored with two different composites. In group 1, a bonding agent (Single Bond 2-SB2; 3M ESPE) and Luna SDI composite in mesial cavities and GC Kalore composite in distal cavities were used. In group 2, Single Bond 2 and GC Kalore composite in mesial cavities and Luna SDI composite in distal cavities were applied. They were then subjected to 2000 thermal cycles in a water bath between 5–55°C (dwell time: 30 seconds in every bath and transfer time: 10 seconds). Then, they were immersed in a 2% basic fuchsin dye solution for 24 hours. After rinsing with water, they were sectioned mesiodistally and evaluated for microleakage using a stereomicroscope. Results. Independent t-test (Mann–Whitney test) showed no statistically significant difference for microleakage in mesial and distal class II restorations between GC Kalore composite and Luna SDI composite (

p

= 1.000) (

p

= 0.852). A total of 83.4% of the Luna SDI composite samples and 66.6% of the GC Kalore composite had a microleakage score of ≤3 in class II cavities. Conclusion. In the present study, marginal microleakage was found mainly at the gingival floor extending to 1/3 of the axial wall for the Luna SDI composite and GC Kalore composite. Furthermore, no statistically significant difference was found between the microleakage of the Class II cavities restored with Luna SDI composite and GC Kalore composite.
Effects of Benson Relaxation Technique and Music Therapy on the Anxiety of Primiparous Women Prior to Cesarean Section: A Randomized Controlled Trial
Authors: Abarghoee Sedigheh Nosrati , Mardani Abbas , Baha Robabe , Aghdam Nasrin Fadaee , Khajeh Mahboobeh , Eskandari Fatemeh , Vaismoradi Mojtaba 
Published: December 2022

Background and Aims. Primiparous women experience high levels of anxiety before cesarean section. Therefore, this research aimed to investigate the effects of the Benson Relaxation Technique (BRT) and Music Therapy (MT) on the anxiety of primiparous women prior to cesarean section. Methods. A randomized controlled trial was carried out on 105 women scheduled for cesarean section. They were randomly assigned into three groups: BRT, MT, and control (n = 35 per group). The women in the BRT and MT groups performed exercises and listened to music, respectively, for 20 minutes prior to cesarean section. The State Anxiety Inventory was used to measure the women’s anxiety in the groups before and after the intervention. Results. Within-group comparisons showed that the women in the BRT (t = 5.61,

p

< 0.001, effect size (Cohen’s d) = 0.94) and MT (t = 3.83,

p

= 0.001, d = 0.64) groups had significantly lower anxiety after the interventions compared to before the interventions. Also, between-group comparisons revealed that anxiety after the intervention was significantly lower in the BRT and MT groups compared to the control group (

p

= 0.007). Conclusions. Although both of the BRT and MT helped with the reduction of anxiety among primiparous women before cesarean section, the BRT was shown more effective. These nonpharmacologic methods are safe and cost-effective and can improve well-being among women undergoing this invasive procedure. They can be used along with pharmacologic methods for reducing overreliance on medications.
Appraisal, Tangible, Self Esteem dan Belonging Support dalam Mempengaruhi Pencapaian Target Penjualan
Authors: Fitriana Fitriana 
Published: December 2022

Sumber daya adalah hal yang tidak bisa dipisahkan dalam sebuah bisnis, baik berupa bahan baku, Sumber daya Manusia,keuangan, dsb. Sebuah bisnis dituntut untuk bisa menyediakan dan mengelolahnya secara efektif dan efisien terhadap sumber-sumber daya yang ada untuk tetap berjalannya kegiatan operasional sebuah usaha.
Dibutuhkan berbagai strategi dengan melihat dua sisi, baik secara Eksternal (ekonomi makro), maupun secara internal (ekonomi mikro). Berdasarkan survey yang dilakukan oleh SBA (Small Business Administration) dikatakan bahwa ditahun ke-5 angka prosentase bisnis yang bertahan hanya sekitar 45-50% (https://www.paper.id). Kondisi-kondisi tersebut tidak terlepas dari bagaimana sebuah manajemen itu dibangun. Karena manajemen yang bagus merupakan salah satu faktor yang mengantarkan sebuah bisnis mampu bertahan dan maju, begitupun sebuah manajemen harus memperhatikan sisi ekonomi makro yaitu bagaimana lingkungan diluar perusahaan ikut mempengaruhi pengambilan keputusan bagi seorang pemimpin perusahaan, seperti kebijakan fiskal yang diterapkan oleh pemerintah, kondisi politik, dsb. Selain itu hal yang tak kalah penting yang harus diperhatikan adalah pengelolaan sumber-sumber daya yang dimiliki oleh perusahaan secara optimal.
Target penjualan merupakan hal yang ingin dicapai oleh sebuah perusahaan, upaya yang bisa dilakukan adalah dengan melakukan pengelolaan/manajemen yang baik, antara lain menyiapkan tenaga penjualan yang profesional. Tenaga penjualan perlu dibangun dan ditingkatkan kinerjanya agar menghasilkan produktivitas yang optimal. Dalam membangun kinerja yang bagus, berpikir postif bukanlah hanya konsep, namun faktor yang krusial dalam meningkatkan kinerja. Pikiran positif yang dimiliki oleh karyawan akan bisa menyelamatkan keberlangsungan hidup sebuah perusahaan, sebaliknya jika tingkat berpikir positif rendah, maka karyawan bagi perusahaan bisa menjadi musuh dari dalam yang setiap saat bisa menghancurkan perusahaan. Agar karyawan tidak menjadi boomerang, maka manajemen perlu mengolah, memoles karyawan menjadi pribadi yang tangguh dalam menghadapi tantangan bisnis, salah satunya dengan memberi dukungan secara sosial, melalui appraisal, tangible, self esteem dan belonging support. Artikel ini merupakan artikel konseptual, yang menggambarkan bagaimana target penjualan bisa dicapai melalui produktivitas yang bagus,yang dibangun melalui pengoptimalan appraisal, tangible, self esteem dan belonging support dalam sebuah manajemen.
Interaction of Blood Pressure and Glycemic Status in Developing Cardiovascular Disease: Analysis of a Nationwide Real‐World Database
Authors: Suzuki Yuta , Kaneko Hidehiro , Yano Yuichiro , Okada Akira , Itoh Hidetaka , Matsuoka Satoshi , Yokota Isao , Imaizumi Takahiro , Fujiu Katsuhito , Michihata Nobuaki , Jo Taisuke , Takeda Norifumi , Morita Hiroyuki , Node Koichi , Yasunaga Hideo , Komuro Issei 
Published: December 2022

Background
Hypertension and diabetes frequently coexist. However, little is known about the interaction between high blood pressure (BP) and hyperglycemia in the development of cardiovascular disease (CVD).

Methods and Results
We conducted an observational cohort study that included 3 336 363 patients (median age, 43 years old; men, 57.2%). People taking BP‐ or glucose‐lowering medications or those with prior history of CVD were excluded. We defined stage 1 hypertension as having systolic BP of 130 to 139 mm Hg or diastolic BP of 80 to 89 mm Hg and stage 2 hypertension as having systolic BP of ≥140 mm Hg or diastolic BP of ≥90 mm Hg. We defined prediabetes as having fasting plasma glucose of 100 to 125 mg/dL and diabetes as having fasting plasma glucose of ≥126 mg/dL. Over a mean follow‐up period of 1185 ± 942 days, 5665 myocardial infarction, 52 475 angina pectoris, 25 436 stroke, 54 508 heart failure, and 12 932 atrial fibrillation events occurred. The BP and fasting plasma glucose categories additively increased the risk of myocardial infarction, angina pectoris, stroke, heart failure, and atrial fibrillation. However, the relative risk of stage 1 and stage 2 hypertension developing into CVD was attenuated with deteriorating glycemic status. Similarly, the relative risk of prediabetes and diabetes developing into CVD was attenuated with increasing BP. For example, the relative risk reduction of stage 2 hypertension for heart failure was 53.5% in individuals with normal fasting plasma glucose, 46.4% in those with prediabetes, and 37.2% in those with diabetes. The robustness of our findings was confirmed using a multitude of sensitivity analyses.

Conclusions
Although hypertension and hyperglycemia additively increase the risk of developing CVD, the relative contribution of hypertension to the development of CVD decreased with deteriorating glycemic status and that of hyperglycemia was attenuated with increasing BP. Our results indicate a potential interaction between hypertension and hyperglycemia in the development of CVD.
Epicardial Fat Volume, Cardiac Function, and Incident Heart Failure: The Rotterdam Study
Authors: Arshi Banafsheh , Aliahmad Hamid A. , Ikram M. Arfan , Bos Daniel , Kavousi Maryam 
Published: December 2022

Background
Larger epicardial fat volume (EFV) has been associated with increased risks of cardiovascular disease and atrial fibrillation. Yet, evidence on the association of EFV with cardiac function and incident heart failure (HF) remains scarce.

Methods and Results
We included 2103 participants (mean age, 68 years; 54.4% women) from the prospective population‐based RS (Rotterdam Study) with computed tomography–based EFV and repeated echocardiography‐based assessment of left ventricular (LV) systolic and diastolic function. Linear mixed effects and Cox‐proportional hazard regression models, adjusted for cardiovascular risk factors, were used to assess the associations of EFV with repeated measurements of echocardiographic parameters and with incident HF. During a median follow‐up of 9.7 years, 124 HF events occurred (incidence rate, 6.37 per 1000 person‐years). For LV systolic function, 1‐SD larger EFV was associated with 0.76 (95% CI, 0.54–0.98) mm larger LV end‐diastolic dimension, 0.66 (95% CI, 0.47–0.85) mm larger LV end‐systolic dimension, and 0.56% (95% CI, −0.86% to −0.27%) lower LV ejection fraction. Interactions between EFV and time were small. For LV diastolic function, 1‐SD larger EFV was associated with 1.02 (95% CI, 0.78–1.27) mm larger left atrial diameter. Larger EFV was also associated with incident HF (hazard ratio per 1‐SD increase in EFV, 1.34 [95% CI, 1.07–1.68] per 1‐SD larger EFV).

Conclusions
We report an independent association between EFV with new‐onset HF in the general population. EFV seems to exert its influence on HF through different pathways contributing to deteriorations in systolic function and larger left atrial size in part, likely through mechanical restraint and hypertrophy.
Combination of Neutrophil‐to‐Lymphocyte and Platelet‐to‐Lymphocyte Ratios as a Novel Predictor of Cardiac Death in Patients With Acute Decompensated Heart Failure With Preserved Left Ventricular Ejection Fraction: A Multicenter Study
Authors: Tamaki Shunsuke , Nagai Yoshiyuki , Shutta Ryu , Masuda Daisaku , Yamashita Shizuya , Seo Masahiro , Yamada Takahisa , Nakagawa Akito , Yasumura Yoshio , Nakagawa Yusuke , Yano Masamichi , Hayashi Takaharu , Hikoso Shungo , Nakatani Daisaku , Sotomi Yohei , Sakata Yasushi ,   the OCVC‐Heart Failure Investigators
Published: December 2022

Background
Neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) are novel inflammation markers. Their combined usefulness for estimating the prognosis of patients with heart failure with preserved ejection fraction (HFpEF) admitted for acute decompensated heart failure remains elusive.

Methods and Results

We investigated 1026 patients registered in the Prospective Multicenter Observational Study of Patients with Heart Failure with Preserved Ejection Fraction. Both NLR and PLR values were measured at the time of admission. Comorbidity burden was defined as the number of occurrences of 8 common comorbidities of HFpEF. The primary end point was cardiac death. The patients were stratified into 3 groups based on the optimal cut‐off values of NLR and PLR on the receiver operating characteristic curve analysis for predicting cardiac death (low NLR and PLR, either high NLR or PLR, and both high NLR and PLR). After a median follow‐up of 429 days, 195 patients died, with 85 of these deaths attributed to cardiac causes. An increased comorbidity burden was significantly associated with a higher proportion of patients with high NLR (>4.5) or PLR (>193), or both. High NLR and PLR values were independently associated with cardiac death, and a combination of both values was the strongest predictor (hazard ratio, 2.66 [95% CI, 1.51–4.70],
P
=0.0008). A significant difference was found in the rate of cardiac death among the 3 groups stratified by NLR and PLR values.

Conclusions
The combination of NLR and PLR is useful for the prediction of postdischarge cardiac death in patients with acute HFpEF.

Registration

URL:
ClinicalTrials.gov
; Unique identifier: UMIN000021831.
Initial Antihypertensive Regimens in Newly Treated Patients: Real World Evidence From the OneFlorida+ Clinical Research Network
Authors: Smith Steven M. , Winterstein Almut G. , Gurka Matthew J. , Walsh Marta G. , Keshwani Shailina , Libby Anne M. , Hogan William R. , Pepine Carl J. , Cooper‐DeHoff Rhonda M. 
Published: December 2022

Background
Knowledge of real‐world antihypertensive use is limited to prevalent hypertension, limiting our understanding of how treatment evolves and its contribution to persistently poor blood pressure control. We sought to characterize antihypertensive initiation among new users.

Methods and Results
Using Medicaid and Medicare data from the OneFlorida+ Clinical Research Consortium, we identified new users of ≥1 first‐line antihypertensives (angiotensin‐converting enzyme inhibitor, calcium channel blocker, angiotensin receptor blocker, thiazide diuretic, or β‐blocker) between 2013 and 2021 among adults with diagnosed hypertension, and no antihypertensive fill during the prior 12 months. We evaluated initial antihypertensive regimens by class and drug overall and across study years and examined variation in antihypertensive initiation across demographics (sex, race, and ethnicity) and comorbidity (chronic kidney disease, diabetes, and atherosclerotic cardiovascular disease). We identified 143 054 patients initiating 188 995 antihypertensives (75% monotherapy; 25% combination therapy), with mean age 59 years and 57% of whom were women. The most commonly initiated antihypertensive class overall was angiotensin‐converting enzyme inhibitors (39%) followed by β‐blockers (31%), calcium channel blockers (24%), thiazides (19%), and angiotensin receptor blockers (11%). With the exception of β‐blockers, a single drug accounted for ≥75% of use of each class. β‐blocker use decreased (35%–26%), and calcium channel blocker use increased (24%–28%) over the study period, while initiation of most other classes remained relatively stable. We also observed significant differences in antihypertensive selection across demographic and comorbidity strata.

Conclusions
These findings indicate that substantial variation exists in initial antihypertensive prescribing, and there remain significant gaps between current guideline recommendations and real‐world implementation in early hypertension care.
Lipoprotein Subclasses Associated With High‐Risk Coronary Atherosclerotic Plaque: Insights From the PROMISE Clinical Trial
Authors: McGarrah Robert W. , Ferencik Maros , Giamberardino Stephanie N. , Hoffmann Udo , Foldyna Borek , Karady Julia , Ginsburg Geoffrey S. , Kraus William E. , Douglas Pamela S. , Shah Svati H. 
Published: December 2022

BACKGROUND
More than half of major adverse cardiovascular events (MACE) occur in the absence of obstructive coronary artery disease and are often attributed to the rupture of high‐risk coronary atherosclerotic plaque (HRP). Blood‐based biomarkers that associate with imaging‐defined HRP and predict MACE are lacking.

METHODS AND RESULTS

Nuclear magnetic resonance–based lipoprotein particle profiling was performed in the biomarker substudy of the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) trial (N=4019) in participants who had stable symptoms suspicious for coronary artery disease. Principal components analysis was used to reduce the number of correlated lipoproteins into uncorrelated lipoprotein factors. The association of lipoprotein factors and individual lipoproteins of significantly associated factors with core laboratory determined coronary computed tomographic angiography features of HRP was determined using logistic regression models. The association of HRP‐associated lipoproteins with MACE was assessed in the PROMISE trial and validated in an independent coronary angiography biorepository (CATHGEN [Catheterization Genetics]) using Cox proportional hazards models. Lipoprotein factors composed of high‐density lipoprotein (HDL) subclasses were associated with HRP. In these factors, large HDL (odds ratio [OR], 0.70 [95% CI, 0.56–0.85];
P
<0.001) and medium HDL (OR, 0.84 [95% CI, 0.72–0.98];
P
=0.028) and HDL size (OR, 0.82 [95% CI, 0.69–0.96];
P
=0.018) were associated with HRP in multivariable models. Medium HDL was associated with MACE in PROMISE (hazard ratio [HR], 0.76 [95% CI, 0.63–0.92];
P
=0.004), which was validated in the CATHGEN biorepository (HR, 0.91 [95% CI, 0.88–0.94];
P
<0.001).

CONCLUSIONS
Large and medium HDL subclasses and HDL size inversely associate with HRP features, and medium HDL subclasses inversely associate with MACE in PROMISE trial participants. These findings may aid in the risk stratification of individuals with chest pain and provide insight into the pathobiology of HRP.

REGISTRATION

URL:
https://clinicaltrials.gov
; Unique identifier: NCT01174550
Clinical Associations of Injuries Caused by Vasovagal Syncope: A Cohort Study From a Tertiary Syncope Unit
Authors: Tajdini Masih , Tavolinejad Hamed , Aminorroaya Arya , Aryan Zahra , Jalali Arash , Alaeddini Farshid , Sadeghian Saeed , Yadangi Somayeh , Vasheghani‐Farahani Ali , Kalhor Parvin , Bozorgi Ali 
Published: December 2022

Background
Recent research has revealed that vasovagal syncope (VVS) leads to a high incidence of injuries; however, clinical associations of injury are not well‐established. We present data from an ongoing VVS cohort and aimed to determine characteristics associated with VVS‐related injury.

Methods and Results
Between 2017 and 2020, consecutive patients ≥18 years of age presenting to a tertiary syncope unit and diagnosed with VVS were included. Clinical characteristics relevant to syncope were obtained for the index episode. The outcome was incidence of injury during VVS, documented by clinical evaluation at the syncope clinic. Among 1115 patients (mean age, 45.9 years; 48% women), 260 injuries (23%) occurred. History of VVS‐related injuries (adjusted relative risk [aRR], 1.80 [95% CI, 1.42–2.29]), standing position (aRR, 1.34 [95% CI, 1.06–1.68]), and female sex (aRR, 1.30 [95% CI, 1.06–1.60]) were associated with injury, whereas recurrent VVS (aRR, 0.63 [95% CI, 0.49–0.81]) and syncope in the noon/afternoon (aRR, 0.70 [95% CI, 0.56–0.87]) and evening/night (aRR, 0.43 [95% CI, 0.33–0.57]) compared with morning hours were associated with lower risk. There was a trend for higher rates of injury with overweight/obesity (aRR, 1.23 [95% CI, 0.99–1.54]) and syncope occurring at home (aRR, 1.22 [95% CI, 0.98–1.51]). In a per‐syncope analysis considering up to 3 previous episodes (n=2518, 36% traumatic), syncope at home (aRR, 1.33 [95% CI, 1.17–1.51]) and absence of prodromes (aRR, 1.34 [95% CI, 1.09–1.61]) were associated with injury.

Conclusions
Patient characteristics, VVS presentations, the circumstances, and surroundings can determine the risk of injury. These associations of VVS‐related injury identify at‐risk individuals and high‐risk situations. Future prospective studies are needed to investigate potential strategies for prevention of post‐VVS injury in recurrent cases.