bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probiotic-derived ecto-5'-nucleotidase produces anti-inflammatory adenosine metabolites in Treg-deficient scurfy mice
Authors: Liu Yuying , Armbrister Shabba A. , Okeugo Beanna , Mills Tingting W. , Daniel Rhea C. , Oh Jee-Hwan , Pijkeren Jan-Peter , Park Evelyn S. , Saleh Zeina M. , Lahiri Sharmistha , Roos Stefan , Rhoads J Marc 
Published: April 2023

Abstract
Probiotic Limosilactobacillus reuteri DSM 17938 (DSM 17938) prolonges the survival of Treg-deficient scurfy (SF) mice and reduces multiorgan inflammation by a process requiring adenosine receptor 2A (A2A) on T cells. We hypothesized that L. reuteri-derived ecto-5’-nucleotidase (ecto-5’NT) activity acts to generate adenosine, which may be a central mediator for L. reuteri protection in SF mice. We evaluated DSM 17938-5’NT activity and the associated adenosine and inosine levels in plasma, gut and liver of SF mice. We examined orally fed DSM 17938, DSM 17938Δ5NT (with a deleted 5’NT gene), and DSM 32846 (BG-R46) (a naturally selected strain derived from DSM 17938). Results showed that DSM 17938 and BG-R46 produced adenosine while “exhausting” AMP, whereas DSM 17938∆5NT did not generate adenosine in culture. Plasma 5’NT activity was increased by DSM 17938 or BG-R46, but not by DSM 17938Δ5NT in SF mice. BG-R46 increased both adenosine and inosine levels in the cecum of SF mice. DSM 17938 increased adenosine levels, whereas BG-R46 increased inosine levels in the liver. DSM 17938Δ5NT did not significantly change the levels of adenosine or inosine in the GI tract or the liver of SF mice. Although regulatory CD73+CD8+ T cells were decreased in spleen and blood of SF mice, these regulatory T cells could be increased by orally feeding DSM 17938 or BG-R46, but not DSM 17938Δ5NT. In conclusion, probiotic-5’NT may be a central mediator of DSM 17938 protection against autoimmunity. Optimal 5’NT activity from various probiotic strains could be beneficial in treating Treg-associated immune disorders in humans.
Experimental Analysis of Mechanical Properties on Hybrid metal Matrix Composite (AA7175/ B4C/SiC)
Authors: Kumar Neeraj Kumar Neeraj , Khanduja Dinesh Khanduja Dinesh , Singh Ravi Pratap Singh Ravi Pratap 
Published: April 2023

Abstract

Hybrid composites are far more superior to existing conventional composites. Among hybrid composites, hybrid aluminum based metal matrix composite plays a pivotal role in the present time. HAMCs have key properties such as less weight-to-strength ratio, high wear & temperature resistance, high hardness, good stiffness, etc. which makes them extremely important in advanced industrial applications, especially in modern sectors such as Automotive, Aerospace, Defense etc. The demand for HAMCs is steeply rising so a thorough understanding of HAMCs becomes important. In this research, AA7175 has been used with SiC, B4C & Graphite as reinforcements in different amounts (3, 6, 9, 12 respectively) of weight percent. Mechanical properties of HAMCs i.e., hardness, tensile strength & percentage elongation have been analyzed. Experimental results show that tensile strength and hardness increase with the increment of reinforcement quantity but percentage elongation decreases. The hardness and tensile strength improved up to 12% of weight of SiC, B4C, and Graphite particles. Few experiments have been done using AA7175/SiC, B4C, and Gr because of which this archive study is unique. This study's methodology could be very helpful for producing high-strength components utilizing Stir Casting, which is a relatively inexpensive casting technique.
Petrographic Characterization and Diagenetic Impact on Bhuban Sandstones of Surma Group, Aizawl, Mizoram
Authors: Bawri Gautam Raj , Vanthangliana V. , Srinivasa K. , Mahanta S. J. , Lalduhawma K. , Bharali Bubul 
Published: April 2023

Abstract
A comprehensive study based on petrographic analyses of Bhuban sandstones belonging to the Surma Group have been carried out in order to determine the various aspects such as depositional environment, tectono-provenance, textural and mineralogical properties, as well as to assess the depositional environment. The most dominant detrital framework constituents of Bhuban sandstone are Quartz (average 83.59%), which is followed by Feldspars (average 7.94%), and Lithic fragments (average 8.47%), matrix, cement, secondary and accessory minerals. The Bhuban sandstone samples are classified as sublith arenite to subarkosic varieties, tightly packed and are characterized by fine to medium-grained with poor to moderately sorted grains. The provenance discrimination diagrams depict the derivation of the detrital framework grains mostly from the upper and middle ranks of metamorphic rocks. The studied sediments were derived from recycled orogen as well as from quartzose recycled, which are marking a composite provenance in humid climate conditions. The study reveals that the area has undergone three distinct diagenetic stages. The Bhuban sandstones have been impacted by several diagenetic processes, which include compaction, cementation, mineral overgrowth, grain fracturing, albitization, recrystallization, replacement, and dissolution of minerals grains. These diagenetic processes that affected the studied samples underwent three different stages of diagenesis, which include early, late, and uplift-related stages. Cementation, minerals replacement, authigenic minerals, quartz and feldspars overgrowth, mechanical compaction, muscovitization, chloritization, concave-convex-suture contacts, recrystallization, albitization, etc. are present which indicates the early to late diagenetic stages of the examined Bhuban sandstones, whereas mechanical compaction, alteration & dissolution of framework grains, precipitation of authigenic minerals and cementation that leads to the decrease the porosity and permeability of the Bhuban sandstones.
Association of atopic dermatitis with schizophrenia and schizoaffective disorder: A case-control study in the All of Us Research Program
Authors: Fan Ryan , Chen Gloria , Leasure Audrey C. , Johnson Matthew C. , Damsky William , Cohen Jeffrey M. 
Published: April 2023

Abstract
Atopic dermatitis (AD) has been previously associated with mental health comorbidities, but studies investigating the relationship between AD and schizophrenia and schizoaffective disorder have been limited. Using electronic health record data from the National Institutes of Health All of Us Research Program (AoURP), we conducted a case-control study comparing rates of schizophrenia and schizoaffective disorder among patients with AD and matched controls. Among 240,635 participants, we identified 13,433 AD cases and 53,732 controls matched to age, sex, and race/ethnicity. When compared to controls, patients with AD were more likely to have a diagnosis of schizophrenia (2.0% vs. 1.1%, P < 0.001) or schizoaffective disorder (1.8% vs. 0.5%, P < 0.001). AD remained significantly associated with schizophrenia (OR 1.64, 95% CI 1.39–1.93) and schizoaffective disorder (OR 2.44, 95% CI 2.01–2.97) in multivariable analyses that adjusted for age, sex, race/ethnicity, income, smoking status, major depressive disorder, and generalized anxiety disorder. Further study is warranted to better understand the pathophysiologic mechanisms behind the relationship between AD and schizophrenia and schizoaffective disorder.
Metabolic Syndrome and Hypovitaminosis D in Children and Adolescents: A Systematic Review
Authors: Martins Gabriele Soares , Silva Isabelle Oliveira Santos da , Santos Gabriele Paiva , Melo Paulo Roberto Santana , Menezes Carlos Alberto 
Published: April 2023

Abstract
Determine the correlation between metabolic syndrome and hypovitaminosis D in children and adolescents.
Data source: systematic review of the literature, PROSPERO registry: CRD42022353545, performed through the evaluation of studies indexed between 2012 and 2022, in the PubMed, ScienceDirect and Web of Science databases. Texts in English and Portuguese were searched for by the DeCS/MeSH descriptors “Metabolic Syndrome” AND “Vitamin D Deficiency” AND Child AND Adolescent. 163 articles were found. After analysis and application of the eligibility criteria, 30 articles were selected.
Data synthesis: 28 were observational and 2 were randomized clinical trials. The samples ranged from 29 to 6589 children and adolescents and the age group between 3 and 18 years. A direct relationship between metabolic syndrome and hypovitaminosis D in pediatrics was identified in 15 studies. Regarding the components of the syndrome, 14 articles highlighted obesity, with a higher frequency of vitamin D deficiency or insufficiency in obese children and adolescents. In addition, 10 articles observed an inverse relationship between 25(OH)D levels and glycemic levels. Finally, vitamin D supplementation was associated with improvement in syndrome parameters.
Conclusions: Thus, the relationship between metabolic syndrome and hypovitaminosis D in pediatrics is evident. Preventive measures are necessary in order to prevent early and future cardiometabolic complications.
Real-world treatment outcomes of carfilzomib plus dexamethasone in patients with relapsed and/or refractory multiple myeloma, focusing on the impact of trial-fitness: Catholic Research Network for Multiple Myeloma Study (CARE-MM 2203)
Authors: Park Sungsoo , Goo Seoyoung , Jeon Youngwoo , Yhang Seungah , Shin Seunghwan , Min Changki 
Published: April 2023

Abstract
Introduction
Carfilzomib plus dexamethasone (Kd) is widely used in patients with relapsed and/or refractory multiple myeloma (RRMM). However, the treatment outcomes of Kd, especially in trial-unfit patients, have not been extensively studied in the real-world setting.
Methods
We analyzed the outcomes of 152 RRMM patients who received Kd at our hospitals from April 2018 to March 2022.
Results
At the commencement of Kd, they received a median of two (range, 1–7) lines of prior anti-myeloma therapy. According to the ENDEAVOR study criteria, 93 (61.2%) and 59 (38.8%) patients were classified as the trial-fit and the trial-unfit group, respectively. The overall response (OR) rate for the entire cohort was 71.1% (95% CI: 63.2%-78.1%). Median time-to-next treatment (TTNT) and overall survival (OS) were 8.0 months (95% CI: 6.8–10.8 months) and 22.8 months (95% CI: 13.4–38.0 months), respectively. There was no significant difference in the OR rate between the trial-fit and the trial-unfit groups (76.3% vs. 62.7%; P = 0.105). However, the median TTNT (5.8 vs. 10.3 months; P < 0.001) and OS (15.0 vs. 36.8 months; P = 0.009) were significantly shorter in the trial-unfit group. On multivariate analysis, trial-fitness (unfit vs. fit) remained a significant covariate affecting the TTNT (HR: 1.65, 95% CI: 1.14–2.40; P < 0.001).
Conclusion
Our data suggest that the treatment outcomes of Kd are acceptable in the real-world setting, with significant differences between the trial-fit and the trial-unfit groups, although they are relatively inferior to those of a pivotal trial.
Primary Pleural Hydatidosis Presenting as an Isolated Cough: A Rare Case Report
Authors: George Marlyn Susan , Jagannath Preethi , Byuzandyan Tigran , Baghumyan Natalie , Khanoyan Armen , Hashmi Md Foorquan 
Published: April 2023

Abstract

Background
Hydatid disease is caused by Echinococcus granulosus organisms. The liver is the most affected organ followed by the lungs. The pleural cavity being the primary location of hydatid cysts is rare and should be discussed further. This paper documents a rare case of primary pleural hydatidosis which can present with a mere isolated cough followed by dyspnea. The diagnosis and surgical treatment along with post-operative medications are vital in this case.
Case presentation
We present a case of a 45-year-old who suffered from a cough for one week which did not subside after taking medications. This symptom was followed by dyspnea for which an X-ray was done which showed left-sided pleuraleffusion, a complication of pleural hydatidosis. Computed tomography was performed to confirm the diagnosis of primarypleural hydatidosis. It revealed multiple cysts in the pleural cavity without them being present at other sites. Blood work revealed eosinophilia which is significant in parasitic diseases. A left posterolateral thoracotomy was performed and the cysts were surgically removed. Additionally, empyemectomy and pleurectomy were done. The patient was then treated with anti-parasitic therapy and was advised to get X-rays during the follow-up visits. The X-rays were normal and indicated that there was no disease recurrence.
Conclusion
This case implies the significance of a cough of more than a week that is not relieved by medications. This should be carefully evaluated and followed in cases that have a rare diagnosis requiring surgery. A diagnosis of primary pleural hydatidosis with left-sided pleural effusion and atelectasis with mediastinal shift to the right side was made which was treated with a surgical procedure.
Prevalence and associated factors with adverse birth outcome among women who gave birth at Debre Markos General Hospital, East Gojjam Zone, Ethiopia, 2022: A cross-sectional study
Authors: Dagnaw Yilkal 
Published: April 2023

Abstract
Background
Adverse birth outcomes are a common public health problem in the developing world, including Ethiopia, and it is important for planning maternal and child health care services. There are several indices of adverse birth outcomes, such as stillbirth, preterm birth, low birth weight, small for gestational age and congenital anomalies.
Objective
This study aimed to determine the prevalence and associated factors of adverse birth outcomes among women who gave birth at Debre Markos General Hospital.
Methods
A health facility-based cross-sectional study was conducted from July 1 to August 1/2022 on laboring women who attended Debre Markos General Hospital. A total of 337 study participants were selected using a systematic sampling method. Data were collected through interviews with a structured questionnaire. Epi Data version 3.1 was used for data entry, and it was checked for completeness, cleared and analysed using Statical Package for Social Sciences software. Bivariable and multivariable logistic regression analyses were employed; a P value of less than 0.05 was considered a statistically significant factor for discontinuation.
Result
- The overall proportion of this study showed that 88 (26.1%) women had adverse birth outcomes, including 26 (7.7%) stillbirths and 31 (9.2%) preterm and low birth weights. Rural residence, no antenatal care, antepartum haemorrhage, pregnancy-induced hypertension, illiteracy, post term pregnancy, birth interval less than two years, and age less than 20 years were independently associated with adverse birth outcomes.
Conclusion
- In this study, the overall proportion of adverse birth outcomes was low compared to previous studies. Residence, no antenatal care follow-up, antepartum haemorrhage, pregnancy-induced hypertension, post term pregnancy, birth interval less than two years, educational status (illiteracy), and age less than 20 years were associated with adverse birth outcomes. Therefore, increasing accessibility and improving awareness in rural communities to seek antenatal care as well as encouraging women's education to higher education levels is vital to improve good birth outcomes.
Analysis of competition and the level of dominance in the antidiabetics market of Russia
Authors: Markov N. I. 
Published: April 2023

Introduction. Amid reports of a growing number of diabetic patients, the antidiabetics market players positioning is highly important for companies and the country’s leadership. The regulatory measures and management decisions depend on the competitive situation in the market. Aim. Analysis of the changes in the level of dominance on the markets for antidiabetics and blood glucose monitors and meters. Materials and methods. The distribution of these markets by product groups, as well as by commercial and public procurement segments has been taken into account. The Herfindahl-Hirschman and Linda indices, the adjusted Hall-Tideman index, concentration ratios and the SV matrix (strength/variety) were used as analysis tools, and the calculations were made on the basis of IQVIA data for the period from 2004 to the 3rd quarter of 2022. Results. The dominance of three foreign companies that fell into the B4 and G quadrants was detected in the insulin and insulin analogues market. The glucose-lowering drugs market is the most competitive, it fell into the RO quadrant more often than other markets, and the dominant group, depending on the segment, included foreign and domestic companies with different frequency. The dominance of both three foreign and one Russian companies in the B4 and G quadrants, as well as a larger number of companies, was identified in the market for other alimentary tract and metabolism products. Several foreign and one Russian company that were identified into the B4 and G quadrants steadily dominated in the markets for blood glucose test strips, glucose monitors and meters and accessories, and lancets. Conclusions. The antidiabetics market is highly concentrated in its segments. The results show the historical development of the studied markets, the role of the commercial and public procurement segments in them, and serve as the foundation for studying the impact of environmental events on the Russian antidiabetics market.
Modeling probabilistic-based reliability assessment of gridded rainfall thresholds for shallow landslide occurrence due to the uncertainty of rainfall in time and space
Authors: Wang Xi-Jun , Wu Shiang-Jen , Tsai Tung-Lin , Yen Keh-Chia 
Published: April 2023

AbstractThis study aims to model a probabilistic-based reliability assessment of the gridded rainfall thresholds for shallow landslide occurrence (RA_GRTE_LS) to quantify the effect of the uncertainty of rainfall in time and space on the rainfall thresholds under consideration of local soil properties. The proposed RA_GRTE_LS model is developed by coupling the uncertainty analysis with the logistic regression equation using a significant number of the landslide-derived rainfall thresholds of the specific warning times. The 30 historical gridded hourly rainstorms at 10 study grids in the study area (Jhuokou River watershed) are used in 1,000 simulations of rainfall-induced shallow landslides under an assumption of the soil layer of 310 cm. The results reveal that the shallow landslide in the study area probably occurs at the time step of less than the 36th hour around the bottom of the soil layer (about 275 cm) during a rainstorm; also, using the proposed RA_GRTE_LS model, the resulting rainfall thresholds and quantified reliabilities, especially for the warning time of less than 18 h, exhibit a sizeable varying trend in space due to the variations in rainfall and soil properties; accordingly, the short-term rainfall thresholds for shallow landslide occurrence could be locally determined under acceptable reliability.
Evaluation of the toxicity of textile effluent treated by electrocoagulation
Authors: Martins Jéssica Elen Costa Alexandre , Abdala Neto Eliezer Fares , Ribeiro Jefferson Pereira , Lima Ari Clecius Alves de , de Souza Francisco Wagner , de Oliveira André Gadelha , Vidal Carla Bastos , do Nascimento Ronaldo Ferreira 
Published: April 2023

Abstract
Textile effluents are complex, making it difficult to choose an effective treatment. The textile effluent toxicity in Lactuca sativa after pulsed current (PC) electrocoagulation (EC) was evaluated in this study. The EC was performed using 304 stainless steel electrodes in batch mode. Parameters monitored included pH, temperature, color, and turbidity. Additionally, the process residue was subjected to energy-dispersive X-ray fluorescence (XFR) to determine the elements present. The process achieved proportional color and turbidity removal ranging from 97 to 99% and from 74 to 85%, respectively. Chemical oxygen demand (COD) and total nitrogen removal were 81 and 49%, respectively, in a 50 min time-lapse. The process generated approximately 1.7 kg of solid residue/m3 treated effluent. The XFR results revealed the presence, mainly, of Fe, Cr, and Ni ions in the residue, as well as chlorine. The germination index (GI) and relative growth values showed that EC reduced effluent toxicity slightly, indicating the need for complementary treatment.
Catalytic ozonation of N-methyldiethanolamine over mixed oxides derived from Mg/Fe-LDH
Authors: Boucenna Nabil , Mokhtari-Belkhadem Fatiha , Bouteiba Ali , Sahel Karima , Medina Francisco , Lounis Mourad 
Published: April 2023

Abstract
The aim of this study was to evaluate the efficiency of catalytic ozonation to increase the degradation of aqueous N-methyldiethanolamine (MDEA) solutions, using two lamellar double hydroxides, namely MgxFe-LDH with x = Mg/Fe = 2, 3, were synthesized by the simple and rapid co-precipitation method. Then, the obtained materials were calcined at 400 °C for 6 h. The calcined products were respectively designated as HTcMg2Fe and HTcMg3Fe, and characterized by powder X-ray diffraction (XRD), N2 physisorption (BET), Fourier transform infrared spectra (FT-IR), and scanning electron microscopy (SEM). The powders produced were used in the ozonation reaction to remove MDEA from aqueous solutions. Experimental results showed that the highest MDEA removal efficiency is in the catalytic ozonation process. Under the optimal conditions for heterogeneous catalytic ozonation of MDEA: initial concentration of 4 Wt% MDEA, 30 °C, catalyst mass of 30 mg/100 ml solution, and contact time of 60 min. The results showed the highest percentage of COD removal, which was up to 80.76% for HTcMg2Fe higher than that of HTcMg3Fe 80.36%.
Реализация теории поэтапного формирования умственных действий в формате дистанционной лекции
Authors: Пронина Анжелика Н. , Будякова Татьяна П. 
Published: April 2023

Введение. В статье рассматриваются методологические и концептуальные вопросы реализации теории поэтапного формирования умственных действий П. Я. Гальперина в условиях дистанционного образования в высшем учебном заведении. Нами впервые проанализирован потенциал теории поэтапного формирования умственных действий П. Я. Гальперина для методического обеспечения дистанционных университетских лекций, описаны векторы ее трансформации в связи с электронным форматом обучения. Методы. Материалом изучения стали лекционные занятия, проводимые на платформе «YouTube». Участниками исследования выступили студенты Елецкого государственного университета имени И. А. Бунина и преподаватели, читавшие им поточные лекции с помощью сервиса «YouTube». В качестве инструмента исследования использовался метод активного интервью со студентами и преподавателями. Обработка результатов осуществлялась с помощью содержательного контент-анализа. Результаты. Было установлено, что и преимущества, и недостатки дистанционных лекций отражают психологию усвоения умственных действий, описанную в теории П. Я. Гальперина. Так, для соответствия стандартам качества образования, содержание образовательного контента, представленного в лекции, должно отвечать требованиям третьего типа обучения по П. Я. Гальперину. Должны быть обеспечены обобщенность и полнота учебного материала при соблюдении условия не превышения объема учебного материала по сравнению с традиционной лекцией. Обсуждение результатов. Полученные результаты свидетельствует о том, что дистанционная форма обучения не исключает успешного применения основных положений теории поэтапного формирования умственных действий, что еще раз доказывает важность данной теории для построения технологий успешного обучения вне зависимости от формата обучения. В контексте развития данной теории высказано мнение о необходимости обучения студентов технике обработки письменной формы дистанционной лекции, переводу ее в формат мини-конспекта.