bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conceptualizing Indigenous strengths-based health and wellness research using group concept mapping
Authors: O’Keefe Victoria M. , Maudrie Tara L. , Cole Ashley B. , Ullrich Jessica S. , Fish Jillian , Hill Kyle X. , White Lauren A. , Redvers Nicole , Jernigan Valarie Blue Bird , Lewis Jordan P. , West Amy E. , Apok Charlene Aqpik , White Evan J. , Ivanich Jerreed D. , Schultz Katie , Lewis Melissa E. , Sarche Michelle C. , Gonzalez Miigis B. , Parker Myra , Neuner Weinstein Sophie E. , McCray Celena J. , Warne Donald , Black Jessica C. , Richards Jennifer R. , Walls Melissa L. 
Published: April 2023

AbstractBackgroundIn recent years public health research has shifted to more strengths or asset-based approaches to health research but there is little understanding of what this concept means to Indigenous researchers. Therefore our purpose was to define an Indigenous strengths-based approach to health and well-being research.MethodsUsing Group Concept Mapping, Indigenous health researchers (N = 27) participated in three-phases. Phase 1: Participants provided 218 unique responses to the focus prompt “Indigenous Strengths-Based Health and Wellness Research…” Redundancies and irrelevant statements were removed using content analysis, resulting in a final set of 94 statements. Phase 2: Participants sorted statements into groupings and named these groupings. Participants rated each statement based on importance using a 4-point scale. Hierarchical cluster analysis was used to create clusters based on how statements were grouped by participants. Phase 3: Two virtual meetings were held to share and invite researchers to collaboratively interpret results.ResultsA six-cluster map representing the meaning of Indigenous strengths-based health and wellness research was created. Results of mean rating analysis showed all six clusters were rated on average as moderately important.ConclusionsThe definition of Indigenous strengths-based health research, created through collaboration with leading AI/AN health researchers, centers Indigenous knowledges and cultures while shifting the research narrative from one of illness to one of flourishing and relationality. This framework offers actionable steps to researchers, public health practitioners, funders, and institutions to promote relational, strengths-based research that has the potential to promote Indigenous health and wellness at individual, family, community, and population levels.
The relationship between fear of Covid-19 and obsessive–compulsive disorder
Authors: Dehghani Maryam , Hakimi Hamideh , Talebi Maryam , Rezaee Hanie , Mousazadeh Noushin , Ahmadinia Hassan , Almasi Saiedeh 
Published: April 2023

Abstract
Background
The coronavirus pandemic and health measures related to it have led to an increase in mental health problems. The relatively high incidence of the disease and its mortality rate created anxiety in society. This study aimed to determine the prevalence of fear of the coronavirus (COVID-19) and its relationship with obsessive–compulsive disorder in patients who attended the outpatient clinic of Besat Hospital in Hamadan.

Methods
In this cross-sectional descriptive study, 320 patients who attended the outpatient clinic of Besat Hospital in Hamadan were selected by random sampling method in 2021. Data were collected using the Fear of the coronavirus (COVID-19) questionnaire and obsessive–compulsive disorder scale and analyzed using SPSS software (V16). They were analyzed using Pearson correlation coefficient and independent t-test.

Results
The mean ± SD age of the subjects was 34.14 ± 9.30 years and 65% of the study subjects were women. The mean ± SD score on the obsessive–compulsive disorder scale was 32.90 ± 19.87 and the mean ± SD score for fear of coronavirus was 16.82 ± 5.79. The contamination dimension of OCD had the highest score of 9.04 ± 5.46 and stealing had the lowest score of 0.10 ± 0.49. The mean fear of COVID-19 in people who had a history of obsessive–compulsive disorder before the quarantine was significantly higher than in those who did not have it (P = 0.002). Along with the increasing fear of coronavirus scale score, the score of obsessive–compulsive disorders increased except for the stealing dimension (P < 0.001).

Conclusions
The results of the study showed that there was a moderate level of fear of COVID-19 among the study population. Also, a relatively high proportion of study subjects had a weak manifestation of OCD. It seems that two years after the beginning of the Covid-19 coronavirus pandemic, people have adapted to the conditions, and their fear of the disease is reduced.
Association Between Biomarkers and Clinical Outcomes of Pembrolizumab Monotherapy in Patients With Metastatic Triple-Negative Breast Cancer: KEYNOTE-086 Exploratory Analysis
Authors: Loi Sherene , Salgado Roberto , Schmid Peter , Cortes Javier , Cescon David W. , Winer Eric P. , Toppmeyer Deborah L. , Rugo Hope S. , De Laurentiis Michelino , Nanda Rita , Iwata Hiroji , Awada Ahmad , Tan Antoinette R. , Sun Yuan , Karantza Vassiliki , Wang Anran , Huang Lingkang , Saadatpour Assieh , Cristescu Razvan , Yearley Jennifer , Lunceford Jared , Jelinic Petar , Adams Sylvia 
Published: April 2023

PURPOSE In the two-cohort phase II KEYNOTE-086 study (ClinicalTrials.gov identifier: NCT02447003 ), first-line and second-line or later pembrolizumab monotherapy demonstrated antitumor activity in metastatic triple-negative breast cancer (mTNBC; N = 254). This exploratory analysis evaluates the association between prespecified molecular biomarkers and clinical outcomes. METHODS Cohort A enrolled patients with disease progression after one or more systemic therapies for metastatic disease irrespective of PD-L1 status; Cohort B enrolled patients with previously untreated PD-L1–positive (combined positive score [CPS] ≥ 1) metastatic disease. The association between the following biomarkers as continuous variables and clinical outcomes (objective response rate [ORR], progression-free survival [PFS], and overall survival [OS]) was evaluated: PD-L1 CPS (immunohistochemistry), cluster of differentiation 8 (CD8; immunohistochemistry), stromal tumor-infiltrating lymphocyte (sTIL; hematoxylin and eosin staining), tumor mutational burden (TMB; whole-exome sequencing [WES]), homologous recombination deficiency-loss of heterozygosity, mutational signature 3 (WES), mutational signature 2 (apolipoprotein B mRNA editing catalytic polypeptide–like; WES), T-cell–inflamed gene expression profile (TcellinfGEP; RNA sequencing), and 10 non-TcellinfGEP signatures (RNA sequencing); Wald test P values were calculated, and significance was prespecified at α = 0.05. RESULTS In the combined cohorts (A and B), PD-L1 ( P = .040), CD8 ( P < .001), sTILs ( P = .012), TMB ( P = .007), and TcellinfGEP ( P = .011) were significantly associated with ORR; CD8 ( P < .001), TMB ( P = .034), Signature 3 ( P = .009), and TcellinfGEP ( P = .002) with PFS; and CD8 ( P < .001), sTILs ( P = .004), TMB ( P = .025), and TcellinfGEP ( P = .001) with OS. None of the non-TcellinfGEP signatures were associated with outcomes of pembrolizumab after adjusting for the TcellinfGEP. CONCLUSION In this exploratory biomarker analysis from KEYNOTE-086, baseline tumor PD-L1, CD8, sTILs, TMB, and TcellinfGEP were associated with improved clinical outcomes of pembrolizumab and may help identify patients with mTNBC who are most likely to respond to pembrolizumab monotherapy.
Comparison between micro-anchor skin dressing and liquid bonding agent for elective knee arthroscopy portal closure
Authors: Manirajan Aaditya , Baker Hayden P , Krishnan Pranav , Mayfield Allison , Athiviraham Aravind , Ho Sherwin 
Published: April 2023

Objective: The objective of the current study was to evaluate outcomes of elective knee arthroscopy portal closure comparing two skin closure techniques. Method: This was a randomised controlled trial including healthy volunteers aged ≥18 years undergoing elective knee arthroscopy that used two portals. At the time of surgery, each patient's two arthroscopy portal closures were randomised to one of two closure techniques; the first technique used approximation of the skin with a micro-anchor skin dressing (BandGrip Inc., US), while the second closure technique used an absorbable suture (Biosyn Monofilament, Medtronic) and a liquid bonding agent skin closure (Dermabond, Ethicon Inc., US). Postoperative complications and patient-reported outcomes were evaluated at the first visit after knee arthroscopy and at six weeks postoperatively. Results: A total of 38 patients (76 portals) were enrolled in this study. No patients reported wound complications of either portal; thus, there was no significant difference (p>0.05) in wound complication rates between the skin closure techniques. Survey questions regarding any difference in appearance and cosmesis between the closure techniques' portal sites were responded to by 15 patients, all of whom indicated no difference in appearance between the portal sites. There was also no statistically significant difference between the two closure techniques with regards to appearance. Conclusion: There was no significant difference in presence of wound complications or appearance between skin closure with the micro-anchor skin dressing and the absorbable suture/liquid bonding agent skin closure.
Performance improvements by dynamic amplifier reconfigurations for C + L-band optical networks in the presence of stimulated Raman scattering
Authors: Huang Zhuili , Dou Liang , Cheng Jingchi , Xie Chongjin , Lu Chao , Lau Alan Pak Tao 
Published: April 2023

C+L-band optical networks suffer from transmission impairments including amplified spontaneous emission noise and Kerr-induced and stimulated-Raman-scattering-induced nonlinear interference. The generalized signal-to-noise ratio (GSNR) profiles across different links of the network play a crucial role in determining the overall network traffic load and operating margins, but the GSNR is highly dependent on the signal power profiles along the link and time-varying channel-loading conditions, particularly for future dynamic mesh networks. As the network is dynamically loaded, we monitor the GSNR across the active channels of each link and investigate the benefits of regularly reconfiguring the erbium-doped fiber amplifier (EDFA) gain and tilts to optimize either (1) the mean GSNR minus the GSNR standard deviation (i.e., to achieve a high and flat GSNR across channels) or (2) the minimum GSNR to improve the traffic load and/or GSNR margins. Different lightpath provisioning strategies are studied, and simulation results for COST 239, a German network, and a sample Alibaba production network show that, compared with static EDFA configurations assuming fully loaded conditions, the GSNR margin and hence network robustness with dynamic EDFA reconfigurations can be improved by at least 0.45, 0.57, and 0.72 dB, respectively, with similar or better network blocking probability. Alternatively, the improved GSNR profiles can enable an average network capacity improvement of at least 9%, 8%, and 16%, respectively, in principle when operating at the same GSNR margin at 30% spectral occupancy.
Virtuelle Welten in der Fernlehre – Eine Studie der Fernhochschule AKAD University
Authors: Rinn Heidi , Markgraf Daniel , Robra-Bissantz Susanne 
Published: April 2023

ZusammenfassungDie Corona-Pandemie hat die Welt der Hochschullehre in vielerlei Hinsicht verändert. In Folge der Beschränkungen häufig eingesetzte Videokonferenzlösungen erwiesen sich für einige Themen als guter Ersatz bei gleichzeitiger Erhöhung der örtlichen Flexibilität. Es wurde aber auch offensichtlich, dass es Lehrformate gibt, die per Videokonferenz nicht ideal umsetzbar sind. Dazu zählen u. a. Seminare mit starkem Fokus auf Gruppenarbeit oder Kursinhalte, die viel Hilfestellung durch den Dozierenden erfordern. Virtuelle Welten werden in diesen Fällen aufgrund ihrer sozialen und räumlichen Präsenz als potenziell bessere Alternative zu Videokonferenzen identifiziert. Als besonders problematisch werden an der Institution, einer deutschen Fernhochschule, zwei Seminare identifiziert, nämlich ein Programmierseminar und ein Wirtschaftsplanspiel. Hierfür wird eine prototypische Lösung mit der virtuellen Welt von TriCAT spaces explorativ gestaltet, durchgeführt und evaluiert. Wir stellen vor, wie diese beiden Seminare erfolgreich in eine virtuelle Welt portiert werden können. Die Evaluierung der Stichprobe (N = 23) zeigt, dass die Umsetzung in 3D demselben Seminar in Zoom in Bezug auf Flow-Erleben zwar nur leicht überlegen ist, allerdings trotzdem die meisten die 3D-Variante vorziehen. Bei der Beobachtung der 3D-Seminare identifizieren wir Verbesserungsmöglichkeiten für nachfolgende Prototypen und legen den Grundstein für vertiefende Forschungen.
A qualitative case study of community experiences with Tungiasis in high prevalence villages of Bungoma County, Kenya: “The whole body aches and the jiggers are torturing me!”
Authors: Mørkve Åse Walle , Sitienei Jackline , Van den Bergh Graziella 
Published: April 2023

Introduction
Tungiasis is a painful skin infection caused by a flea called Tunga Penetrans/jiggers, which enters the epidermis of humans and animals. If untreated it may result in bacterial infection, sepsis, necrosis, and disability. In Kenya, it is estimated that 4% of the population suffer from jigger infestation. The aim of this study was to contribute with knowledge about the experiences of those affected, perceived causes and local coping strategies, to improve the control and elimination of this neglected condition.

Method
A qualitative case study research design was applied involving fieldwork in Bungoma County, a high-prevalence rural area in Western Kenya. Multiple data collection methods were combined: participant observation, home visits, semi- structured in-depth interviews, and group discussions. In total, 48 informants participated, including infected children and adults, teachers and pupils, public health officers, community health workers and NGO volunteers.

Results
Those infected suffered with multiple penetrating wounds on hands and feet that cause disability, resulting in an incapacity to work and school drop-out. People described feeling stigmatized, and at school pupils preferred not to play with infected classmates. People perceived that the sand flea infestation was caused by poverty and that those affected were not even able to cover their basic needs. They were often living in sandy huts that they shared with their animals, without access to soap and clean water. Moreover, those infected were often viewed as ignorant by the rest of the community. Informants perceived recurrence after treatment as inevitable, resulting in creation of hopelessness. Those infected felt that they were left alone with an irremediable plague. There was confusion about effective approaches regarding prevention and treatment at all levels.

Conclusion
Tungiasis is a debilitating and neglected ailment, inflicting severe suffering and increasing the circle of poverty. To address fatalist attitudes among those affected, national guidelines need to be implemented, and coordination of public health measures regarding prevention and treatment need to be strengthened. Further research is recommended to enable the control and elimination of this neglected tropical disease
miR-96-5p is involved in alcohol-induced apoptosis in PC12 cells via negatively regulating TAp73
Authors: Yang Bin , Wang Qi , Li Yanzhong , Li Lin , Zhang YanJie , Leong Bin Abdullah Mohammad Farris Iman , Hao Wei , Li Duan , Zhang Ruiling 
Published: April 2023

Objective
The present study opted for the adrenal phaeochromocytoma (PC12) cell line to frame a neuronal injury model induced by alcohol exposure in vitro, aiming to probe whether TAp73 and miR-96-5p are involved in the neuronal injury process induced by alcohol and elucidate the regulatory relationship between miR-96-5p and TAp73.

Methods
Immunofluorescence staining was used to observe the structural features of PC12 cells after culturing in medium with nerve growth factor (NGF). After different doses and different durations of alcohol treatment, CCK-8 assay was performed to detect the viability of PC12 cells, flow cytometry assay was carried out to detect the apoptosis rate of PC12 cells, dual-luciferase reporter assay was used to definitude the regulatory relationship between miR-96-5p and Tp73, and western blot was used to detect the protein expression of TAp73.

Results
The result of immunofluorescence staining demonstrated that PC12 cells abundantly expressed Map2, CCK-8 assay illustrated alcohol exposure significantly downregulated the cell viability of PC12 cells, Treatment with miR-96-5p inhibitor induced apoptosis and upregulated the expression of TAp73 in PC12 cells. Contrastingly, miR-96-5p mimic reversed the above effects and downregulation of TAp73 inhibited the apoptosis of PC12 cells.

Conclusion
The present study demonstrated that miR-96-5p participates in alcohol-induced apoptosis in PC12 cells via negatively regulating TAp73.
Exploring sex as a moderator of other prognostic variables in whiplash associated disorder: An observational study
Authors: Callan Bradford , Walton David M. , Cleland Joshua , Kolber Morey J. , Elliott James M. 
Published: April 2023

Background
Prognostic variables for assessing people with whiplash associated disorder (WAD) following a motor vehicle collision (MVC) have been evaluated in numerous studies. However, there is minimal evidence assessing how these variables may differ between males and females.

Question/Purpose
1) To assess if the sex of a person interacts with known prognostic variables within the development of chronic WAD. 2) To determine if commonly used outcome measures used in the assessment of chronic WAD differ between sexes.

Methods
The study was a secondary analysis of an observational study with an inception cohort immediately following an MVC in an emergency department in Chicago, IL, USA. Ninety-seven adults aged 18 to 60 (mean 34.7 years old; 74% female) participated in the study. The primary outcome was long-term disability as determined by Neck Disability Index (NDI) scores at 52-weeks post-MVC. Data was collected at baseline (less than 1-week), 2, 12, 52-weeks post MVC. Hierarchal linear regression was used to determine significance (ΔF-score, p < 0.05) and R2 for each of the variables. The primary variables of interest were sex of the participant, age, baseline scores on the numeric pain rating scale (NPRS) and NDI and created interaction terms for sex x z-baseline NPRS and sex x z-NDI.

Results
From analysis 1, both NDI (R2 = 8.7%, p < 0.01) and NPRS (R2 = 5.7%, p = 0.02) collected at baseline predicted significant variance in NDI score at 52-weeks. The interaction term of sex x z-NPRS was also significant (R2 = 3.8%, p = 0.04). In analysis 2 the regression models when disaggregated by sex showed that baseline NDI was the significant predictor of 52-week outcome in males (R2 = 22.4%, p = 0.02) while it was the NPRS as the significant predictor in females (R2 = 10.5%, p < 0.01).
The impact of right ventricular hemodynamics on the performance of a left ventricular assist device in a numerical simulation model
Authors: Thut Titus L. Z. , Petrou Anastasios , Meboldt Mirko , Daners Marianne Schmid , Wilhelm Markus J. 
Published: April 2023

Abstract

Objectives
Left ventricular assist devices (LVADs) have been established as alternative to heart transplantation for patients with end-stage heart failure refractory to medical therapy. Right heart failure (RHF) after LVAD implantation is associated with inferior outcome. Its preoperative anticipation may influence the selection between a pure left ventricular and a biventricular device type and, thus, improve outcomes. Reliable algorithms to predict RHF are missing.

Methods
A numerical model was used for simulation of a cardiovascular circulation. The LVAD was placed as parallel circuit between left ventricle and aorta. In contrast to other studies, the dynamic hydraulic behavior of a pulsatile LVAD was replaced by that of a continuous LVAD. A variety of hemodynamic states was tested mimicking different right heart conditions. Adjustable parameters included heart rate (HR), pulmonary vascular resistance (PVR), tricuspid regurgitation (TR), right ventricular contractility (RVC) and pump speed. Outcome parameters comprised central venous pressure (CVP), mean pulmonary artery pressure (mPAP), cardiac output (CO) and occurrence of suction.

Results
Alteration of HR, PVR, TR, RVC and pump speed resulted in diverse effects on CO, CVP and mPAP, resulting in improvement, impairment or no change of the circulation, depending on the degree of alteration.

Conclusions
The numerical simulation model allows prediction of circulatory changes and LVAD behaviour following variation of hemodynamic parameters. Such a prediction may be of particular advantage to anticipate RHF after LVAD implantation. It may help preoperatively to choose the appropriate strategy of only left ventricular or both left and right ventricular support.
Evaluation of keyness metrics: performance and reliability
Authors: Sönning Lukas 
Published: April 2023

Abstract
The methodological debates surrounding keyword analysis have given rise to a wide range of keyness metrics. The present paper delineates four dimensions of keyness, which distinguish between frequency- and dispersion-related perspectives. Existing measures are then organized according to these dimensions and evaluated with regard to their performance on a specific keyword analysis task: The identification of key verbs in academic writing. To this end, the rankings produced by 32 different metrics are evaluated against an established academic word list. Further, the reliability of measures is assessed, to determine whether they produce stable rankings across repeated studies on the same pair of text varieties. We observe notable differences among metrics with regard to these criteria. Our findings provide further support for the superiority of the Wilcoxon rank sum test and text-dispersion–based measures, and allow us to identify, within each dimension of keyness, metrics that may be given preference in applied work.