bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bicorporates: Decoding the origin and spread of the enigmatic images
Authors: Zakoji Etsuko 
Published: August 2023

AbstractThis paper will focus on bicorporates, the enigmatic composite animals with one head and two bodies which have been left rather outside of scholastic attention. The first known bicorporates appeared on Mesopotamian cylinder seals around the third millennium BCE. They subsequently appeared in Minoan, Greek, Etruscan and Roman art. In mediaeval Europe, they flourished in Romanesque churches, especially, Southern Europe and Scandinavia. Furthermore, they also emerged in India and Southeast Asia and China. Bicorporates exist across a remarkably wide geographical and chronological range. Even though a small number of scholars carried out some research on them, most of their focus was trying to trace the migration route of the images. No previous study had focused on answering the most intriguing question, how these enigmatic images came about and the reason why they spread and recurred beyond geographical and chronological borders. Therefore, this paper will focus on the questions and seek to provide the answers, by applying neuropsychological reading and analytical psychology. The findings of this study suggest that Lewis‐Williams' neuropsychology and Jung's analytical psychology are intertwined and both offer explanations for the origin and widespread occurrence of bicorporate images. However, the contrast between these two theories lies in the fact that Lewis‐Williams' theory relies on the perspective of materialistic science, implying that these images are solely products of the human brain and nervous system. In contrast, Jung's theory allows for the possibility of exploring the invisible or esoteric realm, which cannot be disproven or proven by current materialistic science.
Association between postictal suppression and the therapeutic effects of electroconvulsive therapy: A systematic review
Authors: Langroudi Mahdie Ershad , Shams‐Alizadeh Narges , Maroufi Azad , Rahmani Khaled , Rahchamani Maryam 
Published: August 2023

AbstractElectroconvulsive therapy (ECT) is an effective and safe medical treatment for patients with severe mood and neuropsychiatric disorders. Since the advent of ECT, extensive research has been performed to identify the predictive factors for response to ECT. In recent decades, postictal suppression on an electroencephalogram (EEG) has been considered a potential predictor of response to ECT. We aimed to investigate the direct association between postictal suppression and the therapeutic effects of ECT. In this systematic review, all articles in the field of the association between postictal suppression and the therapeutic effects of ECT published between 1990 and 2021 were identified. The full texts of these articles, which include clinical trials and retrospective and cross‐sectional studies, are available in scholarly research databases and search engines, including PubMed, Google Scholar, OVID, Web of Science, and Scopus. Of all retrieved articles, eight studies, including four retrospective cohort articles and four clinical trials, met the inclusion criteria for further analyses. The findings of this study showed a significant association between postictal suppression and the therapeutic efficacy of ECT. Factors such as electrode placement, tachycardia, type of anesthetic agent, and EEG amplitude were also directly related to postictal suppression and the efficacy of ECT. Postictal suppression on EEG can be considered a predictor of response to ECT. To increase the effectiveness of treatment with ECT and increase postictal suppression, factors including electrode placement, tachycardia, type of anesthesia, and EEG amplitude should be considered, which highlights the need for further research.
Generating Designs for Comparative Experiments with Two Blocking Factors
Authors: Vo-Thanh Nha , Piepho Hans-Peter 
Published: August 2023

Abstract
Often, comparative experiments involve a single treatment factor and two blocking factors, for example, augmented row–column, two-phase, and incomplete row–column experiments. These experiments are widely used in agriculture. Finding good designs for these experiments is a major challenge when the number of treatments is large and the blocking structure is complex. In this paper, we first propose a new search algorithm that is combined with efficient update formulae, so that optimal designs with two blocking factors can be found within a reasonable time. Second, we compare augmented row–column designs generated with our new method to those obtained from CycDesigN, DiGGer, and the OPTEX procedure of SAS in terms of computing times as well as the quality of solutions. Third, we illustrate our proposed approach with four applications. We show an example where our efficient update formulae work while existing update formulae cannot be applied, and we use our search framework to generate augmented row–column, two-phase, and incomplete row–column designs. We end the paper with a conclusion along with suggestions for potential applications.
An easy‐to‐use semi‐automatic volumetric evaluation for secondary bone grafting in patients with unilateral alveolar cleft
Authors: Teramoto Mizuki , Katsube Motoki , Utsunomiya Natsuko , Katayama Yasuhiro , Yamanaka Hiroki , Tsuge Itaru , Sowa Yoshihiro , Sakamoto Michiharu , Morimoto Naoki 
Published: August 2023

AbstractSurgical intervention for alveolar bone formation is important in patients with alveolar cleft; however, the treatment methods and materials are still controversial. A precise evaluation method for postoperative bone formation is important for comparing outcomes and establishing the best treatment protocol. The purpose of this study is to establish a new method of evaluating surgical outcomes for patients with alveolar cleft. Computed tomography datasets from 20 patients who underwent secondary alveolar bone grafting were obtained before and 1 year after surgery. Six anatomical landmarks were used to superimpose the preoperative and mirrored preoperative volume and postoperative volume data. The cleft region was segmented by subtracting the preoperative from mirrored preoperative volume data, and the failed osteogenesis region was segmented by subtracting the postoperative volume data from the cleft region; subsequently, the bone formation ratio was calculated. Two observers performed this method using a free software 3D slicer and the average evaluation times were 12.7 and 13.2 min for observers 1 and 2, respectively. Method reliability was determined by evaluating intraclass correlation coefficients. The intra‐observer intraclass correlation coefficients were 0.97 and 0.96 for observers 1 and 2, respectively. The inter‐observer intraclass correlation coefficient was 0.97. Our method is practical for assessing bone formation after treatment, which does not require specific knowledge or software and can be used by ordinary physicians.
Do Companies Think and Feel? Mind Perception of Organizations
Authors: Tang Simone , Gray Kurt 
Published: August 2023

AbstractHow do people perceive the minds of organizations? Existing work on organizational mind perception highlights two key debates: whether organizational groups are ascribed more agency than experience, and whether people are really perceiving minds in organizational groups at all. Our current paper and its data weigh in on these debates and suggest that organizations can indeed be ascribed experiential minds. We present a “member and goals” framework for systematically understanding the mind perception of organization. This framework suggests that people can perceive the organizational mind through its elemental building blocks: members (people who form the organization) and goals (its aims). Four studies reveal that people ascribe agency and experience to organizations based on whether the members of organizations and the goals of the organization are characterized by agency or experience. Study 1 finds that past work on mind perception often examines for‐profit corporations, which consist of agentic members (corporate professionals) and agentic goals (market competition). Studies 2 and 3 reveal that when an organization with members and goals high (vs. low) in experience, people imbue its mind with perceived experience—equal to that of a person—and that even emotions low in warmth (i.e., anger) can imbue an organization with such perceptions. Study 4 shows the moral consequences of emphasizing experience: after organizational wrongdoing, experiential organizations are seen to deliver more sincere apologies and are more forgiven.
A nitrobenzodioxazole‐based water‐soluble chemosensor for colorimetric quantification of aqueous hypochlorite
Authors: Moon Sungjin , Gil Dongkyun , Kim Cheal 
Published: August 2023

AbstractA nitrobenzoxadiazole (NBD)‐based colorimetric chemosensor CNA (N,N,N‐trimethyl‐2‐(2‐(7‐nitrobenzo[c][1,2,5]oxadiazol‐4‐yl)hydrazineyl)‐2‐oxoethan‐1‐aminium chloride) was synthesised. The sensor CNA can detect hypochlorite (ClO−) via colour variation of yellow to colourless. The detection limit for ClO− by CNA was analysed to be 0.36 μM. Moreover, the naked‐eye test strip was successfully applied for ClO− detection. The probing mechanism of CNA to ClO− was proposed to be a hydrolytic cleavage reaction of CNA by ClO− and was demonstrated by electrospray ionisation mass spectrometry (ESI‐MS), Fourier‐transform infrared (FTIR), proton nuclear magnetic resonance (1H NMR) analysis and density functional theory (DFT) calculations.
Abandoning grassland management negatively influences plant but not bird or insect biodiversity in Europe
Authors: Elliott Tessa , Thompson Amibeth , Klein Alexandra‐Maria , Albert Christian , Eisenhauer Nico , Jansen Florian , Schneider Andrea , Sommer Martin , Straka Tanja , Settele Josef , Sporbert Maria , Tanneberger Franziska , Mupepele Anne‐Christine 
Published: August 2023

AbstractGrasslands are globally distributed and naturally occurring; however, in Europe, most grasslands are anthropogenically created or altered by livestock grazing or mowing. Low‐intensity use and management have led to species‐rich communities in European grasslands. The intensification of crop production and livestock farming with stabling throughout the year has led to an abandonment of grasslands that are no longer economically profitable. In this study, we looked at the influence of grassland abandonment on biodiversity. We hypothesized that abandonment of grasslands decreases the overall biodiversity, but has different effects depending on the focal taxonomic group (i.e., vascular plants, insects, or birds). We also hypothesized that the type of management before abandonment, the type of grassland, and the time after abandonment would influence grassland biodiversity. We conducted a Web of Science search, with pre‐defined terms, to find articles that compared biodiversity of managed and abandoned grasslands in Europe. We screened the articles and included 39 studies in a subsequent meta‐analysis. We found that overall biodiversity was reduced after abandonment; however, the biodiversity reduction in the grasslands differed among taxonomic groups. Plant species diversity was significantly lower after abandonment (plant summary effect size: −0.25 [−0.34; −0.16]), whereas the diversity of insects and birds showed no significant trend, but a visual trend toward an increase. None of the other environmental variables (type of management, type of grassland, or the time after abandonment) had a significant influence on the biodiversity of the grasslands. We conclude that maintaining grassland management is crucial to support biodiversity conservation in European grasslands.
Illicit drugs in the emergency department: Can we determine on clinical grounds if patients are intoxicated? Results from the Western Australian Illicit Substance Evaluation (WISE) study
Authors: McCutcheon David , Soderstrom Jessamine , Raghavan Mohan , Oosthuizen Francois , Douglas Bianca , Burrows Sally , Smith Jennifer L. , Fatovich Daniel 
Published: August 2023

AbstractIntroductionPresentations related to illicit drugs are a feature of emergency department practice. Clinicians may form a belief that a patient is intoxicated with illicit drugs based on patient self‐report, clinical features on presentation and the local prevalence of illicit drug use. But evidence of the accuracy of this assessment is lacking. The Western Australian Illicit Substance Evaluation (WISE) study enrolled patients believed by their treating clinician to be intoxicated with illicit drugs, and this analysis aims to evaluate the validity of this belief.MethodsA blood sample was taken on patient arrival and details of patient history, examination and interventions were collected by clinical and research staff. Toxicological examination of biological samples used liquid chromatography‐mass spectrometry techniques including Quadrupole Time of Flight screening and Triple Quadrupole targeted analyses.ResultsOf 632 study presentations, 518 had illicit drugs detected representing a positive predictive value of 0.82 (95% confidence interval 78.7, 84.9). Those with illicit drugs detected were significantly less likely to arrive by police transport (p = 0.010) or to have used alcohol (p < 0.001). They were significantly more likely to report illicit drug use (p < 0.001) and a much smaller proportion were admitted to a psychiatric ward (3.5% vs. 19.3%, p < 0.0001). Heart rate and systolic blood pressure were significantly higher in the illicit drug group (p = 0.004 and p = 0.003).Discussion and ConclusionsIn this study, the positive predictive value of clinicians determining if their patient had taken illicit drugs was 0.82. Contemporaneous biochemical analysis in the clinical setting would increase this accuracy and inform patient care.
‘I accept his manhood is on life‐support’: A qualitative understanding of the impact of diabetes on sexual relationships among men and women living with type 2 diabetes and their partners in South Africa
Authors: van Pinxteren Myrna , Delobelle Peter , Levitt Naomi , Smith Kirsten , Majikela‐Dlangamandla Buyelwa , McGrath Nuala 
Published: August 2023

AbstractAimsTo explore the impact of diabetes on sexual relationships among men and women living with type 2 diabetes People living with type 2 diabetes (PLWD) and their partners in Cape Town, South Africa.MethodsAs part of a larger study developing an intervention to improve type 2 diabetes mellitus (T2DM) self management, we conducted in‐depth individual interviews with 10 PLWD and their partners without diabetes about experiences living with T2DM, between July 2020 and January 2021. We used inductive thematic analysis.ResultsBoth PLWD and partners felt that their sexual relationships and desires changed post‐diagnosis, in ways beyond biomedical issues. Although couples' reports on the quality of their sexual relationships were concordant, most participants had not communicated their sexual desires and concerns with each other, causing unhappiness and fears of disappointing or losing their partner. Participants felt uninformed about sexual dysfunction but had not discussed this with their healthcare provider, leading to increased anxiety.ConclusionPLWD and their partners need more informational support to increase their understanding of diabetes‐associated sexual dysfunction and to decrease fears and anxiety. Strengthening communication within couples on sexual issues may empower them to find solutions to problems experienced. This may improve couples' relationships and quality of life, and indirectly result in better self management of T2DM.
Gestational diabetes: One size does not fit all—an observational study of maternal and neonatal outcomes by maternal glucose profile
Authors: Yeung Roseanne O. , Retnakaran Ravi , Savu Anamaria , Butalia Sonia , Kaul Padma 
Published: August 2023

AbstractObjectivesTo examine obstetrical and neonatal outcomes across maternal glucose profiles at the population level and to explore insulin sensitivity and beta‐cell function across profiles in an independent, well‐phenotyped cohort for potential pathophysiologic explanation.Research Design and MethodsObservational cohort study of all pregnancies with gestational diabetes screening between October 2008 and December 2018 resulting in live singleton birth in Alberta, Canada (n = 436,773) were categorized into seven maternal glucose profiles: (1) normal 50 g‐glucose challenge test (nGCT), (2) normal 75‐g OGTT (nOGTT), (3) isolated elevated 1 h post‐load glucose (ePLPG1), (4) isolated elevated 2 h post‐load glucose (ePLPG2), (5) elevated 1 and 2 h post‐load glucose (ePLPG12), (6) isolated elevated FPG (eFPG), and (7) elevated FPG + elevated 1‐h and/or 2‐h PLG (Combined). Primary outcomes were large for gestational age (LGA) and neonatal intensive care unit (NICU) admission rates. An independent observational cohort of 1451 women was examined for measures of beta‐cell function (ISSI‐2, insulinogenic index/HOMA‐IR) and insulin sensitivity/resistance (Matsuda index, HOMA‐IR) by similar maternal glucose profiles.ResultsPregnancies with elevated FPG, either isolated or combined, had higher adverse events and lower insulin sensitivity. The combination of elevated FPG + elevated 1‐h and/or 2‐h PLG had the highest rates of LGA(20.9%), NICU admissions (14.7%), and lowest insulin sensitivity as measured by Matsuda index and HOMA‐IR, and beta‐cell function as measured by ISSI‐2 and Insulinogenic index/HOMA‐IR.ConclusionsElevated fasting plasma glucose, either alone or combined with post‐load glucose elevation is associated with worse outcomes than isolated post‐load glucose elevation, possibly due to higher degrees of insulin resistance. Future work is needed to better understand these differences, and explore whether tailored treatment of GDM can improve neonatal outcomes.
Multilevel climatic responses in migratory insects
Authors: Juhász Edit , Németh Zoltán , Gór Ádám , Végvári Zsolt 
Published: August 2023

Abstract
Evidence is mounting that migration in ectotherms is more widespread than formerly believed. Thus, a number of insects living in temperate climates, including locusts, butterflies, moths and dragonflies, following seasonal migration strategies show high responsiveness to alterations in climatic processes, similar to a broad taxonomic range of birds. On global scales, migratory insects include iconic large butterflies, dragonflies and also a number of crop pests. However, insect migrations are ecologically distinct from those of vertebrates, often relying heavily on seasonal winds and multiple generations to complete a full annual cycle, due to short insect life spans.
Here, we review publicly available online resources to identify key patterns of spatial, taxonomic scales and complexity of climatic responsiveness to environmental predictors in migratory insects.
We found that migratory insects respond to various levels of complexity in climatic patterns, and these responses are predicted by life history and ecological traits: (i) responses to climatic effect type were predicted by climate zone(s) of the distribution area, whereas (ii) response to climatic complexity was predicted by body size. In conclusion, migratory insects respond to various levels of complexity in climatic processes, and this responsiveness is governed by a substantially wider array of environmental predictors than demonstrated in vertebrates.
Clinical efficacy of simoctocog alfa versus extended half‐life recombinant FVIII concentrates in hemophilia A patients undergoing personalized prophylaxis using a matching‐adjusted indirect comparison method
Authors: Kessler Craig M. , Corrales‐Medina Fernando F. , Mannucci Pier Mannuccio , Jiménez‐Yuste Víctor , Tarantino Michael D. 
Published: August 2023

AbstractObjectivesWe aimed to indirectly compare the efficacy of personalized prophylaxis with simoctocog alfa (Nuwiq®) versus three extended half‐life (EHL) recombinant FVIII (rFVIII) concentrates.MethodsTreatment effects were compared using matching‐adjusted indirect comparisons after matching individual patient‐level baseline characteristics for simoctocog alfa (pharmacokinetic [PK]‐guided personalized prophylaxis) against published aggregate personalized prophylaxis data for efmoroctocog alfa, damoctocog alfa pegol, and rurioctocog alfa pegol.ResultsA higher percentage (p < .001) of patients with zero bleeds was found with simoctocog alfa compared with efmoroctocog alfa (75% vs. 45%), damoctocog alfa pegol (77% vs. 38%), and rurioctocog alfa pegol (target trough level 1%–3%; 78% vs. 42%). Similar efficacy was found comparing simoctocog alfa against rurioctocog alfa pegol 8%–12% (77% vs. 62%). The mean total annualized bleeding rate was lower (p < .001) with simoctocog alfa than damoctocog alfa pegol (1.5 vs. 4.9). Consistent with approved dosing, the mean FVIII weekly dose was higher (p < .001) for simoctocog alfa than efmoroctocog alfa, damoctocog alfa pegol, or rurioctocog alfa pegol 1%–3%, but lower (p < .001) than rurioctocog alfa pegol 8%–12%.ConclusionsIndirect comparisons demonstrated that PK‐guided, personalized prophylaxis with simoctocog alfa can lead to higher zero bleed rates compared with personalized EHL rFVIII concentrate regimens, albeit with higher weekly doses, and a lower percentage of patients treated twice weekly or less.
Identifying patients at risk for hereditary myeloid malignancy syndromes incorporating a novel, self‐administered questionnaire to an initial screening platform
Authors: Zahid Mohammad Faizan , Moriarty Kelsey , Dryden Courtney , Weinberg Olga , Asif Misha , Ikpefan Ruth , Anderson Julia M. , Collins Robert H. , Chung Stephen S. , Chen Weina , Patel Prapti A. , Madanat Yazan F. 
Published: August 2023

AbstractIntroductionFour to 10% of cases of myeloid malignancies are inherited. We report our experience on hereditary myeloid malignancy syndromes (HMMS) incorporating a novel questionnaire in the screening platform for patients with myeloid malignancies and aplastic anemia.MethodsThe questionnaire was sent via electronic patient portal prior to clinic visits. Patients screened positive based on responses to questionnaire items, presence of suspicion disease characteristics (young age, family history, monosomy 7 etc.) and/or presence of signs of HMMS. Those deemed at‐risk based on questionnaire responses, clinical features and/or somatic mutation profile were offered germline testing.ResultsA total of 408 patients were screened, 141 (35%) were deemed at‐risk. Fifty‐four (38%) of at‐risk patients were seen in the genetics clinic. Forty‐one (76%) of the patients seen agreed to germline testing and 13 declined due to cost or personal decision. Twenty pathogenic (P)/likely‐pathogenic (LP) germline mutations were identified in 16 (39%) of the tested patients. Five patients also had a variant of uncertain significance (VUS) and an additional 13 had at least 1 VUS without P/LP mutations (total 29 VUS's were found in 18 (44%) of tested patients). The median age of diagnosis for patients with P/LP mutations was 56 years versus 66 years in the entire cohort.ConclusionIncorporating an electronic questionnaire is an effective screening method for HMMS. Many patients declined testing due to cost. These results highlight the importance of germline testing in patients with myeloid malignancies, further research in HMMS, and coverage by healthcare plans.