bluuebunny/crossref_metadata_2025_split huggingface dataset:
Konsens und Konflikt in einem Machtmodell von Planung
Authors: Reuter Wolf 
Published: May 2023

Planning in pluralistic societies implies to propose measurements in situations of dissent and unsolved conflicts. Insofar it is congruent with the domain of politics, inclusive the involvement in the network of effects on existing or awakened, mostly divergent interests. In the resulting case of conflict, their respective representatives try to influence the plan – by their arguments in a rational discourse and by means of power. However, argumentation itself turns out to be a mean of power: As their agents try to push through themselves against resistance, they definitively enter the mechanisms of power acting. Following these considerations, a power model of planning is developed, with its logical structure, its calculi, means and instruments, as it is embedded in its societal conditions, with its ethical positions and including trials to hinder its misuse by procedures.
Combined effects of functional overload and denervation on skeletal muscle mass and its regulatory proteins in mice
Authors: Uemichi Kazuki , Shirai Takanaga , Takemasa Tohru 
Published: May 2023

AbstractSkeletal muscle is a highly pliable tissue and various adaptations such as muscle hypertrophy or atrophy are induced by overloading or disuse, respectively. However, the combined effect of overloading and disuse on the quantitative adaptation of skeletal muscle is unknown. Thus, the aim of this study was to investigate the effects of the combined stimuli of overloading and disuse on mouse skeletal muscle mass and the expression of regulatory factors for muscle protein anabolism or catabolism. Male mice from the Institute Cancer Research were subjected to denervation concomitant with unilateral functional overload or functional overload concomitant with unilateral denervation. Disuse and functional overload were induced by sciatic nerve transection (denervation) and synergist ablation, respectively, and the plantaris muscle was harvested 14 days after the operation. Our results showed that denervation attenuated functional overload‐induced muscle hypertrophy and functional overload partially ameliorated the denervation‐induced muscle atrophy. P70S6K phosphorylation, an indicator of mechanistic target of rapamycin complex 1 (mTORC1) activation, was not increased by unilateral functional overload in denervated muscles or by unilateral denervation in functional overloaded muscles. Denervation did not affect the increase of LC3‐II, a marker of autophagy activation, and ubiquitinated protein expression upon unilateral functional overload. Also, functional overload did not affect ubiquitinated protein expression during unilateral denervation. Thus, our findings suggest that functional overload‐induced muscle hypertrophy or denervation‐induced muscle atrophy was attenuated by the combined stimuli of overload and denervation.
On Andrei Bely’s poetic philosophy and art of fiction
Authors: Guan Haiying , Li Yuhua 
Published: May 2023

Abstract
As a unique literary theory, Andrei Bely’s symbolism is a religious world view, and his “symbols” are deeply rooted in the symbolist’s cognition of world structure. This distinct world view exerts a special effect on Bely’s exploration of the poetic mechanism of symbolism. In the practice of completing the creation of symbolic image, the construction of symbolic text, and the achievement of artistic function, word, rhythm, and color are among the most important and necessary conditions to help Bely produce a polyphonic aesthetic effect.
New conticrete inequalities of the Hermite-Hadamard-Jensen-Mercer type in terms of generalized conformable fractional operators via majorization
Authors: Saeed Tareq , Khan Muhammad Adil , Faisal Shah , Alsulami Hamed H. , Alhodaly Mohammed Sh. 
Published: May 2023

AbstractThe Hermite-Hadamard inequality is regarded as one of the most favorable inequalities from the research point of view. Currently, mathematicians are working on extending, improving, and generalizing this inequality. This article presents conticrete inequalities of the Hermite-Hadamard-Jensen-Mercer type in weighted and unweighted forms by using the idea of majorization and convexity together with generalized conformable fractional integral operators. They not only represent continuous and discrete inequalities in compact form but also produce generalized inequalities connecting various fractional operators such as Hadamard, Katugampola, Riemann-Liouville, conformable, and Rieman integrals into one single form. Also, two new integral identities have been investigated pertaining a differentiable function and three tuples. By using these identities and assuming∣f′∣| f^{\prime} |and∣f′∣q(q>1)| f^{\prime} {| }^{q}\hspace{0.33em}\left(q\gt 1)as convex, we deduce bounds concerning the discrepancy of the terms of the main inequalities.
Ensuring safety of new, advanced small modular reactors for fundamental safety and with an optimal main heat transport systems configuration
Authors: Gaikwad Avinash J. , Maheshwari Naresh K. , Chandrakar Dinesh K. , Solanki R. B. , Bhanuprakash  , Paul Uttam K. 
Published: May 2023

Abstract
Many countries are considering Small and Modular Reactors as a viable alternative to counter the climate-change/global-warming with a quick deployment of green, carbon free nuclear energy option in the energy mix. Proponents of SMRs claim that these designs rely more on enhanced inherent/engineered safety and passive features with novel concepts. SMRs are being designed to be fabricated at a factory and then transported as ‘modules’ to the sites for installation either as a single module or multiple module plant. There are many variant of SMRs under considerations/design/construction/commissioning/operation states and majority of the, more than 70 odd SMRs are in the design stage. The paper focuses on safety aspects while addressing the fundamental safety requirement that are derived from fundamental safety principles, the acceptance criteria, the expected/envisaged safety targets and not only the economic impact/considerations. The assessment basis for requirements towards safety enhancements and their extent of assurance in the design are highlighted against the claims made. Ensuring SMR safety with respect to the fundamental safety functions will depend on the foreseen/predicted fission product releases, following overheating of the fuel, during the worst/credible accident conditions and likelihood of occurrence of these accidents. Innovations in the development of advanced fuel, deploying passive safety systems, novel concepts in main heat transport system configuration and advanced features in instrumentation can help in realising the goal of ensured enhanced safety in the SMRs, both in preventive and mitigation domains during severe accidents. Enhancements in the acceptance criteria and deterministic and probabilistic safety targets is also expected and may be envisaged. The paper brings out the challenges faced in the design and regulation of the new NPPs, while addressing fundamental safety principles implementation, generic, specific safety issues, and only genuine innovations can ensure and improve the safety. Aspects related to passive systems and the optimal main heat removal system configuration of the NPPs are also discussed. The aspects related to concurrent design and regulation of new NPPs including SMRs also has been brought out in the paper.
The association between polycystic ovary syndrome and environmental pollutants based on animal and human study; a systematic review
Authors: Ghanati Kiandokht , Jahanbakhsh Mahdi , Shakoori Attaollah , Aghebat-Bekheir Saeed , Khalili-Rikabadi Ali , Sadighara Parisa 
Published: May 2023

Abstract
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders. This abnormality is identified with hyperandrogenism, polycystic ovary and ovulation disorder. Environmental factors are one of the etiologies of this disease. In this systematic review, a search was performed with the keywords of polycystic ovary syndrome, PCOS, pesticides, organochlorine, heavy metals, PCBs, PAHs, bisphenol A, BPA, phthalates, mycotoxin, Tributyltin, TBT, environmental contaminants, regardless of publication time. 567 studies were obtained and after assessing 26 articles were finally selected. 61 % of the studies were attributed to bisphenol A. The positive correlation was seen between bisphenol A, tributyltin, air pollutants and organic contaminates with this disease. The association between this syndrome and bisphenol A in adolescents was also confirmed. Zinc has led to a reduction in the incidence of disease in almost all research literature. This issue can be considered in the prevention of the disease.
Why Do Platforms Charge Proportional Fees? Commitment and Seller Participation
Authors: Muthers Johannes , Wismer Sebastian 
Published: May 2023

AbstractThis paper deals with trade platforms whose operators not only allow third party sellers to offer their products to consumers, but also offer products themselves. In this context, the platform operator faces a hold-up problem if he uses classical two-part tariffs only as potential competition between the platform operator and sellers reduces platform attractiveness. Since some sellers refuse to join the platform, some products that are not known to the platform operator will not be offered at all. We find that revenue-based fees lower the platform operator’s incentives to compete with sellers, increasing platform attractiveness. Therefore, charging such proportional fees can be profitable, which may explain why several trade platforms indeed charge proportional fees.
Immune synaptopathies: how maternal immune activation impacts synaptic function during development
Authors: Matteoli Michela , Pozzi Davide , Fossati Matteo , Menna Elisabetta 
Published: May 2023

AbstractIn the last two decades, the term synaptopathy has been largely used to underline the concept that impairments of synaptic structure and function are the major determinant of brain disorders, including neurodevelopmental disorders. This notion emerged from the progress made in understanding the genetic architecture of neurodevelopmental disorders, which highlighted the convergence of genetic risk factors onto molecular pathways specifically localized at the synapse. However, the multifactorial origin of these disorders also indicated the key contribution of environmental factors. It is well recognized that inflammation is a risk factor for neurodevelopmental disorders, and several immune molecules critically contribute to synaptic dysfunction. In the present review, we highlight this concept, which we define by the term “immune‐synaptopathy,” and we discuss recent evidence suggesting a bi‐directional link between the genetic architecture of individuals and maternal activation of the immune system in modulating brain developmental trajectories in health and disease.
A CcdB toxin‐derived peptide acts as a broad‐spectrum antibacterial therapeutic in infected mice
Authors: Bhowmick Jayantika , Nag Manish , Ghosh Pritha , Rajmani Raju S , Chatterjee Ritika , Karmakar Kapudeep , Chandra Kasturi , Chatterjee Jayanta , Chakravortty Dipshikha , Varadarajan Raghavan 
Published: May 2023

AbstractThe bacterial toxin CcdB (Controller of Cell death or division B) targets DNA Gyrase, an essential bacterial topoisomerase, which is also the molecular target for fluoroquinolones. Here, we present a short cell‐penetrating 24‐mer peptide, CP1‐WT, derived from the Gyrase‐binding region of CcdB and examine its effect on growth of Escherichia coli, Salmonella Typhimurium, Staphylococcus aureus and a carbapenem‐ and tigecycline‐resistant strain of Acinetobacter baumannii in both axenic cultures and mouse models of infection. The CP1‐WT peptide shows significant improvement over ciprofloxacin in terms of its in vivo therapeutic efficacy in treating established infections of S. Typhimurium, S. aureus and A. baumannii. The molecular mechanism likely involves inhibition of Gyrase or Topoisomerase IV, depending on the strain used. The study validates the CcdB binding site on bacterial DNA Gyrase as a viable and alternative target to the fluoroquinolone binding site.
Mapping single‐cell responses to population‐level dynamics during antibiotic treatment
Authors: Kim Kyeri , Wang Teng , Ma Helena R , Şimşek Emrah , Li Boyan , Andreani Virgile , You Lingchong 
Published: May 2023

AbstractTreatment of sensitive bacteria with beta‐lactam antibiotics often leads to two salient population‐level features: a transient increase in total population biomass before a subsequent decline, and a linear correlation between growth and killing rates. However, it remains unclear how these population‐level responses emerge from collective single‐cell responses. During beta‐lactam treatment, it is well‐recognized that individual cells often exhibit varying degrees of filamentation before lysis. We show that the cumulative probability of cell lysis increases sigmoidally with the extent of filamentation and that this dependence is characterized by unique parameters that are specific to bacterial strain, antibiotic dose, and growth condition. Modeling demonstrates how the single‐cell lysis probabilities can give rise to population‐level biomass dynamics, which were experimentally validated. This mapping provides insights into how the population biomass time‐kill curve emerges from single cells and allows the representation of both single‐ and population‐level responses with universal parameters.
Study of the use of IVIG Normal Human Immunoglobulin in the La Samaritana University Hospital during the period of 2017-2019
Authors: Quiroga Robayo Lizeth Daniela , Montaño Avila Mónica Patricia , López Gutiérrez José Julián 
Published: May 2023

Introducción: La inmunoglobulina humana intravenosa inespecífica (IGIV) es un valioso recurso terapéutico en patologías específicas, sin embargo, existen condiciones patológicas para las que aún no existe una estrategia terapéutica definida y por similitud o plausibilidad biológica algunos prescriptores terminan usándola.
Objetivo: Identificar las indicaciones para las cuales se ha prescrito inmunoglobulina humana inespecífica intravenosa (IGIV) en el HUS.
Metodología: Se realizó un estudio observacional descriptivo de corte transversal con recolección retrospectiva de la información entre enero 1 de 2017 hasta diciembre 31 de 2019. Materiales y métodos: Se revisaron 180 historias clínicas, de pacientes a quienes se les prescribió al menos una dosis de inmunoglobulina, se realizó una caracterización demográfica, clínica y farmacológica de la población estudio. Además, se comparó las indicaciones descritas en la historia clínica con las indicaciones aprobadas por el INVIMA.
Resultados: Se identificó a mujeres adultas jóvenes como población a quienes se le prescribió IGIV con mayor frecuencia. Asimismo, las indicaciones para la que se prescribe IGIV con mayor frecuencia fueron la purpura trombocitopenia idiopática (PTI), síndrome de Guillain-Barré (SGB), lupus eritematoso sistémico (LES) e ictericia neonatal debida a otras hemolisis existentes. Las indicaciones aprobadas por la agencia regulatoria colombiana (INVIMA) son inespecíficas por lo que el uso de la IGIV es prescrito ya sea por similitud o plausibilidad biológica, lo cual puede explicar el uso no prescrito que en este estudio alcanzó la cifra del 71%.
Conclusión: Las indicaciones de mayor prescripción con IGIV fue purpura trombocitopenia idiopática (PTI) y síndrome de Guillain-Barré (SGB). El uso no prescrito de IGIV en este estudio alcanzó la cifra del 71%.
Integrated management of yellow rust caused by Puccinia striiformis f. sp. tritici in wheat
Authors: Lavilla M. , Peper A. 
Published: May 2023

Introduction. Yellow rust caused by Puccinia striiformis f. sp. tritici, is currently the main disease of wheat (Triticum aestivum) in the north of the province of Buenos Aires, Argentina. It has caused yield losses close to 20 %. Objective. To evaluate the effect of different agronomic management systems on wheat yield and incidence of yellow rust. Materials and methods. The trial was carried out in the town of Pergamino, Buenos Aires, Argentina, during the years 2019, 2020, and 2021. The experimental design was in subdivided plots, the largest plot was with and without cover crop, the subplot was agronomic management, and the sub-subplot the application was foliar fungicide at different phenological stages of the wheat crop. Results. With the use of foliar fungicides in stages close to stem elongation and the use of a cultivar resistant to the disease produced a reduction in the area under the disease progress curve (AUCPE) by 62.50 %, which translated into significant grain yield increases of 29.52 %. Foliar fungicide application resulted in a 16.94 % increase in wheat yield. The implementation of a sustainable integrated management system generated yield increases of 29.52 %. Conclusions. The use of a resistant cultivar and the application of a foliar fungicide at early stages and with low levels of the disease, significantly reduced the AUCPE of yellow rust and increased the wheat yield in experimental plots.
Historical sources in exam tests: An analysis of school leaving exam tasks in terms of the use of primary sources
Authors: Kojanitz László 
Published: May 2023

AbstractIn 2005 the Hungarian school-leaving examination system underwent a significant transformation. In case of history the aim was to give a greater role to the development of students' knowledge acquisition and source analysis skills by more focusing on students' work with historical sources in classes. However, it was clear that the achievement of these goals would also depend on the new exam tasks. Those determine whether the reform will be able to get real change. So I carefully examined those tasks of the past fifteen years exams that contained primary sources. I wanted to give an accurate picture of which types of tasks were most frequent and how they could be assessed in terms of the original objectives of the reform and the competency requirements of the school leaving examination. Based on the conclusions drawn from the results of the investigation, I formulate proposals for changing the composition of the exam tasks and preparing for writing the tasks.
Assessment of biventricular myocardial systolic function in COVID-19 patients: A Tissue Doppler Imaging echocardiography study
Authors: Yurdakul Selen , Akdeniz Cansu Selcan , Özden Özge , Mendi Onur , Dalar Levent , Şamilgil Özgür , Tokdil Kardelen Ohtaroglu , Çiftçi Çavlan 
Published: May 2023

AbstractBackgroundThe 2019 novel coronavirus disease (COVID-19) has been reported as pandemy and the number of patients continues to rise. Based on recent data, cardiac injury is a prominent feature of the disease, leading to increased morbidity and mortality. In the present study we aimed to evaluate myocardial dysfunction using transthoracic echocardiography (TTE) and tissue Doppler imaging (TDI) in hospitalized COVID-19 patients.Methods and ResultsWe recruited 30 patients (56.7% male, 55.80 ± 14.949 years) who were hospitalized with the diagnosis COVID-19 infection. We analyzed left ventricular (LV) and right ventricular (RV) conventional and TDI parameters at the time of hospitalization and during the course of the disease. Patients without any cardiac disease and with preserved LV ejection fraction (EF) were included. TTE examination was performed and all the variables were recorded and analyzed retrospectively.We observed that both LV and RV conventional echocardiographic parameters were similar when the day of admission to the hospital was compared to the 5th day of the disease. Regarding TDI analysis, we demonstrated significant impairment in LV septal and lateral deformation (P < 0.001). In the correlation analysis no marked correlation was observed between impairment in LV deformation and inflammation biomarkers.ConclusionCardiac involvement is an important feature of the COVID-19 infection but the exact mechanism is still undefined. Echocardiography is an essential technique to describe myocardial injury and provide new concepts for the possible definitions of cardiac dysfunction.
Using Fintech to protect the strict compliance principle in letter-of-credit law
Authors: Bui Le Thuc Linh , Pribula László 
Published: May 2023

AbstractThe focus of this paper is on the uncertainty and controversy associated with the substantial compliance standard as part of the strict compliance principle in the letter of credit law, as well as the possibility of applying new technology to solve such problems. The letter of credit confirms a payment under international sales contracts and contains a promise from the bank to pay the seller if they can present the complying documents as required in the letter of credit. Thanks to the basic principles of a letter of credit, it is stable and trustworthy. Such basic principles as well as the practice of letters of credit are recognized in the Uniform Customs and Practice for Documentary Credit of the International Chamber of Commerce.To retain the commercial utility of the letter of credit, the strict compliance principle should be revitalized and consistently applied. However, this principle is not associated with exact standards, which leads to the scenario that courts apply different standards. Such a situation might reduce the commercial utility of letters of credit. Hence, the financial industry is trying to apply new technologies such as blockchain, smart contracts, and the Internet of Things to support the strict compliance principle, and try to reduce the uncertainty related to the substantial compliance standard.
Business and human rights, free speech, surveillance, and illiberalism: Contextualizing academic freedom as a constitutional right and an emerging freedom under international law
Authors: Pap András L. 
Published: May 2023

AbstractWith special focus on free speech, as well as on classroom surveillance (proliferating in the Covid-pandemic digital learning environment), the paper aims to identify contextual dimensions for academic freedom as a matured legal concept – and one to be assessed via a business and human rights approach, due to its peculiar position between the public and private spheres. The project is triggered by the fact that despite its widespread usage in international documents and domestic constitutions, academic freedom remains underdeveloped in terms of conceptual tools, operationalizing mechanisms, monitoring methods and benchmarking schemes. There are also competing notions on how to best conceptualize it: as an individual right, a set of requirements for autonomous institutional design, a field to be regulated for market service providers or public commodities, a tool for international policy making, or academic ranking – not to mention the challenge of how to incorporate challenges brought by social justice movements. These considerations all require different policy tools and adjacent legal targeting.