bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rotor mechanism and its mapping in atrial fibrillation
Authors: Xu Chang-Hao , Xiong Feng , Jiang Wei-Feng , Liu Xu , Liu Tao , Qin Mu 
Published: February 2023

AbstractTreatment of atrial fibrillation (AF) remains challenging despite significant progress in understanding its underlying mechanisms. The first detailed, quantitative theory of functional re-entry, the ‘leading circle’ model, was developed more than 40 years ago. Subsequently, in decades of study, an alternative paradigm based on spiral waves has long been postulated to drive AF. The rotor as a ‘spiral wave generator’ is a curved ‘vortex’ formed by spin motion in the two-dimensional plane, identified using advanced mapping methods in experimental and clinical AF. However, it is challenging to achieve complementary results between experimental results and clinical studies due to the limitation in research methods and the complexity of the rotor mechanism. Here, we review knowledge garnered over decades on generation, electrophysiological properties, and three-dimensional (3D) structure diversity of the rotor mechanism and make a comparison among recent clinical approaches to identify rotors. Although initial studies of rotor ablation at many independent centres have achieved promising results, some inconclusive outcomes exist in others. We propose that the clinical rotor identification might be substantially influenced by (i) non-identical surface activation patterns, which resulted from a diverse 3D form of scroll wave, and (ii) inadequate resolution of mapping techniques. With rapidly advancing theoretical and technological developments, future work is required to resolve clinically relevant limitations in current basic and clinical research methodology, translate from one to the other, and resolve available mapping techniques.
Somatic nuclear blebbing in Caenorhabditis elegans is not a feature of organismal aging but a potential indicator of germline proliferation in early adulthood
Authors: Fan Qiang , Li Xue-Mei , Zhai Chao , Li Bin , Li Shang-Tong , Dong Meng-Qiu 
Published: February 2023

Abstract
Abnormal nuclear morphology is suggested to be a hallmark of aging and one such abnormality is nuclear blebbing. However, little is known about whether and how nuclear blebbing participates in animal aging, and what regulates it. In this study, we show that the frequency of nuclear blebbing in the hypodermis increases during aging in wild-type C. elegans. These nuclear blebs are enveloped by the nuclear lamina, the inner and the outer nuclear membrane, and 42% of them contain chromatin. Although nuclear blebbing could lead to DNA loss if chromatin-containing blebs detach and fuse with lysosomes, we find by time-lapse imaging that nuclear blebs rarely detach, and the estimated lifetime of a nuclear bleb is 772 h or 32 days. The amount of DNA lost through nuclear blebbing is estimated to be about 0.1% of the total DNA loss by adult Day 11. Furthermore, the frequency of nuclear blebbing does not correlate with the rate of aging in C. elegans. Old age does not necessarily induce nuclear blebbing, neither does starvation, heat stress, or oxidative stress. Intriguingly, we find that proliferation of germ cells promotes nuclear blebbing.
Oxaliplatin plus irinotecan vs irinotecan as second-line treatment in pancreatic cancer patients: a randomized–controlled open-label Phase II study
Authors: Zhang Hangyu , Tong Zhou , Liu Lulu , Fu Qihan , Zhu Xudong , Dai Xiaomeng , Bao Xuanwen , Fang Weijia , Zheng Yi , Zhao Peng 
Published: February 2023

Abstract

Background
Limited second-line therapeutic options are available for metastasis pancreatic cancer (mPC). We aimed to explore the efficacy and safety of oxaliplatin plus irinotecan (IROX) in mPC patients.

Methods
This is an open-label, Phase 2, randomized study of mPC patients (aged 18–75 years) who failed when using gemcitabine plus S-1 as first-line therapy. Block randomization with a block size of four was used to randomly assign patients (1:1) between October 2015 and December 2017 to receive either IROX (oxaliplatin 85 mg/m2 and irinotecan 160 mg/m2) or irinotecan monotherapy (irinotecan 180 mg/m2) until disease progression, unacceptable adverse events, or consent withdrawal. The primary end point was overall survival, and the secondary end points were progression-free survival, overall response rate, and adverse event rate.

Results
A total of 74 patients were enrolled in this study, including 44 males and 30 females, with an average age of 61 years. The median overall survival was 10.2 and 6.7 months (adjusted hazard ratio [HR], 0.7; 95% confidence interval [CI], 0.4–1.2; P = 0.20) and the median progression-free survival was 5.1 and 2.3 months (adjusted HR, 0.4; 95% CI, 0.2–0.6; P &lt; 0.01) in the IROX group and irinotecan group, respectively. The overall response rates were 18.4% (7/38) in the IROX group and 5.5% (2/36) in the irinotecan group (P = 0.06). Grade 3–4 adverse events occurred in 34% (13/38) of patients in the IROX group and 19% (7/36) of patients in the irinotecan group (P = 0.15).

Conclusions
IROX had no significant survival benefit over irinotecan monotherapy in our study. However, IROX reduced the risk of disease progression by 60%, with acceptable toxicity.
Microbial Dynamics in Newly Diagnosed and Treatment Naïve IBD Patients in the Mediterranean
Authors: Rausch Philipp , Ellul Sarah , Pisani Anthea , Bang Corinna , Tabone Trevor , Marantidis Cordina Claire , Zahra Graziella , Franke Andre , Ellul Pierre 
Published: February 2023

Abstract

Background
Microbial communities have long been suspected to influence inflammatory processes in the gastrointestinal tract of patients with inflammatory bowel disease. However, these effects are often influenced by treatments and can rarely be analyzed in treatment-naïve onset cases. Specifically, microbial differences between IBD pathologies in new onset cases have rarely been investigated and can provide novel insight into the dynamics of the microbiota in Crohn’s disease (CD) and ulcerative colitis (UC).

Methods
Fifty-six treatment-naïve IBD onset patients (67.3% CD, 32.7% UC) and 97 healthy controls were recruited from the Maltese population. Stool samples were collected after diagnosis but before administration of anti-inflammatory treatments. Fecal microbial communities were assessed via 16S rRNA gene sequencing and subjected to ecological analyses to determine disease-specific differences between pathologies and disease subtypes or to predict future treatment options.

Results
We identified significant differences in community composition, variability, and diversity between healthy and diseased individuals—but only small to no differences between the newly diagnosed, treatment-naïve UC and CD cohorts. Network analyses revealed massive turnover of bacterial interactions between healthy and diseased communities, as well as between CD and UC communities, as signs of disease-specific changes of community dynamics. Furthermore, we identified taxa and community characteristics serving as predictors for prospective treatments.

Conclusion
Untreated and newly diagnosed IBD shows clear differences from healthy microbial communities and an elevated level of disturbance, but only the network perspective revealed differences between pathologies. Furthermore, future IBD treatment is to some extent predictable by microbial community characteristics.
Morphology of pig nasal structure and modulation of airflow and basic thermal conditioning
Authors: Yuk Jisoo , Akash Mohammad Mehedi Hasan , Chakraborty Aneek , Basu Saikat , Chamorro Leonardo P , Jung Sunghwan 
Published: February 2023

Abstract
Mammals have presumably evolved to adapt to a diverse range of ambient environmental conditions through the optimized heat and mass exchange. One of the crucial biological structures for survivability is the nose, which efficiently transports and thermally preconditions the external air before reaching the internal body. Nasal mucosa and cavity help warm and humidify the inhaled air quickly. Despite its crucial role, the morphological features of mammal noses and their effect in modulating the momentum of the inhaled air, heat transfer dynamics, and particulate trapping remain poorly understood. Tortuosity of the nasal cavity in high-olfactory mammalian species, such as pigs and opossum, facilitates the formation of complex airflow patterns inside the nasal cavity, which leads to the screening of particulates from the inhaled air. We explored basic nasal features in anatomically realistic nasal pathways, including tortuosity, radius of curvature, and gap thickness; they show strong power-law correlations with body weight. Complementary inspection of tortuosity with idealized conduits reveals that this quantity is central in particle capture efficiency. Mechanistic insights into such nuances can serve as a tipping point to transforming nature-based designs into practical applications. In-depth characterization of the fluid–particle interactions in nasal cavities is necessary to uncover nose mechanistic functionalities. It is instrumental in developing new devices and filters in a number of engineering processes.
Supranational or cooperative? Rethinking the African Continental Free Trade Area Agreement Competition Protocol institutional design
Authors: Kigwiru Vellah Kedogo 
Published: February 2023

Abstract
African countries are currently negotiating the African Continental Free Trade Area (AfCFTA) Competition Protocol (CP) to regulate competition in the created continental market. However, the most daunting task for the negotiators and African countries is which institutional design to adopt at the continental level, pitying against a supranational or cooperative institutional model. Drawing from a dearth of literature on institutional designs, I propose two factors that African countries should consider when deciding on the most appropriate institutional design for the AfCFTA CP. First are the benefits and costs of each institution design building on the experiences of existing regional competition regimes. Second is the institutional context in which the AfCFTA Continental Competition Regime (CCR) will be established, which constitutes African countries’ attitudes towards supranational institutions, preference heterogeneity, and power distributions. The findings of this article show that African countries should establish a less ambitious institution design that will attract business and political acceptance.
Wet-food diet promotes the recovery from surgery of castration and control of body weight in adult young cats
Authors: Bian Zhaowei , Jian Xiaoying , Liu Guanbao , Jian Shiyan , Wen Jiawei , Zhang Han , Lin Xinye , Huang Hongcan , Deng Jinping , Deng Baichuan , Zhang Lingna 
Published: February 2023

AbstractInappropriate dietary management may lead to delayed recovery from castration surgery and significant weight gain in cats after castration. Wet canned food often exhibits more advantageous characteristics than dry food (e.g., higher palatability and digestibility, and lower energy density). This study compared the effects of canned and dry food on surgical recovery and weight management in cats after castration. Eighteen healthy cats (weighed 4.33 ± 1.04 kg and aged 18-months old) were allocated to one of the two dietary treatments (N = 9/group), dry (CON) and canned food (CAN) balanced for sex and initial BW. Cats were fed ad libitum for 7 weeks, including one week before surgery (week 0) and 6 weeks after surgery (week 1–6). Daily dry matter intake (DMI), and weekly body weight (BW) and body condition score (BCS) was obtained. Feces were collected for measuring nutrient digestibility and concentrations of short-chain fatty acids (SCFA) and branched-chain fatty acids (BCFA). Physical pain and wound surface assessment were performed at week 1. Blood was also collected intermittently for measuring biochemical indices and untargeted metabolomics analysis. Results indicated that BW, BCS and daily DMI in CON group increased (P &lt; 0.05) over time after castration, but were maintained relatively stable in CAN group. Cats in CAN group exhibited less pain-related behavior as reflected by lower score of comfort (P &lt; 0.05) and vocalization (P &lt; 0.10), improved wound surface assessment (P &lt; 0.10), lower level of lipase (P &lt; 0.10) and ratio of blood urea nitrogen/serum creatinine (BUN/SC; P &lt; 0.05), and higher level of superoxide dismutase (SOD; P &lt; 0.05) in week 1 than CON cats. Meanwhile, the CAN group had significantly higher concentration of immunoglobulin G (IgG) on days 5 and 7, and higher level of high-density lipoprotein cholesterol (HDL-C; P &lt; 0.10) but lower triglyceride (TG; P &lt; 0.05) than CON group on day 20 and 48. Fecal total and most individual SCFA increased significantly from week 1 to week 6 regardless of diet, but the increase of butyric acid over time only occurred in CON group (P &lt; 0.05). Also, serum metabolomic analysis revealed differential metabolic pathways between the two groups. Overall, compared with the dry food, the canned food tested in our study promoted cat wound recovery by reducing pain and increasing immune and antioxidative capacity after sterilizing surgery, and helped to maintain healthy body condition in cats after castration.
Burn Injury From Smoking Electronic Cigarettes While on Supplemental Oxygen
Authors: Montoya Ana , Ozhathil Deepak , Hollowed Kathleen , Kahn Steven A 
Published: February 2023

AbstractMany reports pertaining to burns from e-cigarette battery explosions exist, as do injuries from smoking conventional cigarettes while on home-oxygen therapy. However, literature regarding burn injuries from e-cigarettes while on oxygen therapy is limited. The heating coil of the device can rise to temperatures that facilitates ignition of oxygen. The purpose of this study is to describe and characterize this novel and under-reported mechanism of injury. This study was a descriptive review of 2013–2016 National Burn Repository (NBR) data, with a query for “oxygen,” “O2,” “electronic cigarettes,” and various permutations/abbreviations/misspellings. Demographics, injury characteristics, and outcomes were reported. Also, a Google search for lay-press articles and a PubMed/Scopus search using similar terms was conducted to find literature. Of approximately 60,000 NBR entries, 8 records of injury while smoking e-cigarettes on oxygen were found. Patients were predominantly male, 63 ± 9 years old, with 3.4% ± 4 TBSA burns, and LOS of 5.8 ± 7 days (an LOS O/E ratio of 1.5). Two patients sustained full-thickness burns (0.5% and 11% TBSA). Three were intubated, with mean of 3.33 ventilator-days. Most injuries occurred at home (88%). All patients survived. A google search revealed five lay-press articles. Only three partially relevant scientific articles were found to only mention the phenomenon, without granular data. Although uncommon, smoking e-cigarettes on supplemental oxygen can result in injury without a lithium-ion battery explosion. Limitations in the database may have resulted in underestimation of injuries. A paucity of relevant literature exists, necessitating more research. Patients who receive home-O2 should be warned about this potential danger.
The Impact of Systematic Insecticides Against Emerald Ash Borer on Phenology of Urban Ash Trees
Authors: Mwangola Dorah M , Kees Aubree M , Grosman Donald M , Aukema Brian H 
Published: February 2023

AbstractThe continued threat of emerald ash borer (Agrilus planipennis; EAB) to North American ash trees (Fraxinus spp.) has necessitated the use of systemic insecticide treatments as a primary control strategy against EAB in urban centers. Altered tree phenology due to systemic insecticides could mediate nontarget effects on other insect species, such as seed weevils or leaf-feeders, but whether such injections alter phenological events has not been studied. This study assessed the effects of systemic injections of emamectin benzoate or azadirachtin relative to untreated controls on the spring and fall phenology of mature green ash trees in Saint Paul, MN, USA from fall 2017 to spring 2019. EAB was first detected in this area in 2009. Trees showed minor, visible signs of EAB infestation at study initiation, but not mortality. We examined six phenological events: bud swelling, budburst, flowering, leaf out, leaf color change, and leaf abscission using a visual survey protocol. The timing of phenological events was similar across the different treatments for all but two of events; budburst and flowering. Budburst and flowering occurred 7 d and 5 d earlier, respectively, in treated trees than untreated trees. Given symptoms observed, we posit that delays in these events in untreated trees were due to infestations of EAB and the treatments of emamectin benzoate or azadiractin simply preserved the original phenology. The results from this study suggest that systemic insecticides may mitigate changes in ash tree phenology such as delayed leaf out that may be early symptoms of emerald ash borer.
Cockroaches as Trojan Horses for Control of Cockroach Aggregations With Baits
Authors: Hamilton Jamora A , Wada-Katsumata Ayako , Schal Coby 
Published: February 2023

AbstractGel bait formulations of insecticides have been shown to be highly effective in managing German cockroach (Blattella germanica L. [Blattodea: Ectobiidae]) populations. Three potential reasons for this are high palatability of baits, the use of slow-acting insecticides, and their horizontal transfer within aggregations, a phenomenon known as ‘secondary mortality’. Our objective was to determine whether horizontal transfer can go beyond secondary, to tertiary and quaternary effects, and to compare various gel baits with different active ingredients. We fed adult females a bait and recorded their bait consumption, moribundity, and mortality. Groups of first instars were then exposed to the dead females and their feces, secondary mortality was quantified, and a new cohort of nymphs was then exposed to the feces and dead nymphs (for tertiary mortality); this process was repeated for quaternary mortality. This design did not distinguish among the major mechanisms of horizontal transfer of insecticides, namely coprophagy and contact with feces, exposure to regurgitated fluids, and cannibalism and necrophagy of nymphs. All the tested baits caused 100% mortality of the adult females that directly fed on the bait and high secondary mortality (average of &gt;85%) within 48 hr. Baits containing either dinotefuran, emamectin benzoate, fipronil, or indoxacarb caused tertiary mortality (average of 15–70%), but only the fipronil and indoxacarb baits caused some quaternary mortality. The relative importance of secondary, tertiary, and quaternary transfer of the active ingredient remains to be determined in field populations of the German cockroach.
The Human Cost of Collusion: Health Effects of a Mexican Insulin Cartel
Authors: Barkley Aaron 
Published: February 2023

Abstract
Despite recent attention to the role of competition in determining health outcomes in developed nations, little is known about how market power impedes access to quality care in lower-income countries. This paper studies the effects of policy changes that stopped collusion among firms supplying insulin to one of Mexico’s largest health care providers. I document increased insulin utilization and decreased diabetes complications and mortality following the sudden drop in insulin prices caused by the cartel’s collapse. These adverse health outcomes expand the assessment of damages caused by the cartel. The findings highlight the importance of market design policies in health markets, particularly for low- and middle-income countries.
Precision Ephemerides for Gravitational-wave Searches – IV. Corrected and refined ephemeris for Scorpius X-1
Authors: Killestein T L , Mould M , Steeghs D , Casares J , Galloway D K , Whelan J T 
Published: February 2023

ABSTRACTLow-mass X-ray binaries have long been theorized as potential sources of continuous gravitational-wave radiation, yet there is no observational evidence from recent LIGO/Virgo observing runs. Even for the theoretically ‘loudest’ source, Sco X-1, the upper limit on gravitational-wave strain has been pushed ever lower. Such searches require precise measurements of the source properties for sufficient sensitivity and computational feasibility. Collating over 20 yr of high-quality spectroscopic observations of the system, we present a precise and comprehensive ephemeris for Sco X-1 through radial velocity measurements, performing a full homogeneous re-analysis of all relevant data sets and correcting previous analyses. Our Bayesian approach accounts for observational systematics and maximizes not only precision, but also the fidelity of uncertainty estimates – crucial for informing principled continuous-wave searches. Our extensive data set and analysis also enables us to construct the highest signal-to-noise ratio, highest resolution phase-averaged spectrum of a low-mass X-ray binary to date. Doppler tomography reveals intriguing transient structures present in the accretion disc and flow driven by modulation of the accretion rate, necessitating further characterization of the system at high temporal and spectral resolution. Our ephemeris corrects and supersedes previous ephemerides, and provides a factor three reduction in the number of templates in the search space, facilitating precision searches for continuous gravitational-wave emission from Sco X-1 throughout the upcoming LIGO/Virgo/KAGRA O4 observing run and beyond.
Orienting to Pedagogical Service
Authors: Kim Catrina S 
Published: February 2023

AbstractThis essay considers the Society for Music Theory’s valuations of research, service, and pedagogy in light of Sara Ahmed’s (2006) reflections on orientation and labor. Ahmed’s description of the philosopher’s writing table turns attention to the domestic labor that creates the conditions for the very work of philosophizing; by bringing this analysis to bear on Stephen Lett’s “Making a Home of The Society for Music Theory, Inc.” (2023), this article brings the following question to the fore: What sorts of labor are “relegated to the background” of the SMT members’ own “writing tables”? This article thus extends Lett’s metaphor of the SMT’s homemaking practices, questions the meaning of service through the lens of pedagogy and research, and highlights the role of academic contingent labor within this network.
Who Does the Society for Music Theory Gather?
Authors: VanHandel Leigh 
Published: February 2023

Abstract
An important question in Stephen Lett’s provocative article is K’eguro Macharia’s, “Who is gathered by your invitation?” (2021). Lett outlines how the founders of the Society for Music Theory staked out territory for the discipline to establish theorists as separate from composers, musicologists, and pedagogues, and how they assessed who was to be invited by determining what theory as a discipline was and what it was to be. He then discusses how others have been (and still are) invited or excluded based on principles present since the founding of the society and offers suggestions for how to make SMT as an institution more welcoming by using the ideas of homemaking and world-building. My response addresses two topics: first, that the narrow view of the discipline of music theory present at its inception created an anti-pedagogy bias that exists to this day; and second, that this narrow view is perpetuated by graduate programs, which can and should be changed in order to achieve the goal of diversification of the discipline and its members.