bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new prognostic signature based on cancer associated fibroblast-driven genes in breast cancer
Authors: Wu Zizheng , Wei Yuanjun , Liu Yinfeng , Zheng Jie , Yan Weitao , Liu， Jiani , Han Meng , Li Tong 
Published: April 2023

Abstract
Background
Breast cancer, a leading malignant disease, affects women all over the world. Cancer associated fibroblasts (CAFs) stimulate epithelial-mesenchymal transition, and induce chemoresistance and immunosuppression.
Objective
This study aims to establish a CAFs-associated prognostic signature to improve BC patient outcome estimation.
Methods
We retrieved the transcript profile and clinical data of 1072 BC samples from TCGA databases, and 3661 BC samples from the GEO. CAFs and immune cell infiltrations were quantified using CIBERSORT algorithm. CAF-associated gene identification was done by WGCNA. A CAF risk signature was established via univariate, LASSO regression, and multivariate Cox regression analyses. The receiver operating characteristic (ROC) and Kaplan-Meier curves were employed to evaluate the predictability of the model. Subsequently, a nomogram was developed with the risk score and patient clinical signature. Using Spearman's correlations analysis, the relationship between CAF risk score and gene set enrichment scores were examined.
Results
Employing an 8-gene (IL18, MYD88, GLIPR1, TNN, BHLHE41, DNAJB5, FKBP14, and XG) signature, we attempted to estimate BC patient prognosis. Based on our analysis, high-risk patients exhibited worse outcomes than low-risk patients. Multivariate analysis revealed the risk score as an independent indicator of BC patient prognosis. ROC analysis exhibited satisfactory nomogram predictability. The AUC showed 0.805 at 3 years, and 0.801 at 5 years in the TCGA cohort. We also demonstrated that a reduced CAF risk score was strongly associated with enhanced chemotherapeutic outcomes. CAF risk score was significantly correlated with most hallmark gene sets.
Conclusion
We introduced a newly-discovered CAFs-linked gene signature, which served as an independent marker of BC patient prognosis.
Severity and Mortality of Acute Respiratory Failure in Pediatrics: A Prospective Cohort at 2,600 Meters Above Sea Level
Authors: Vargas-Acevedo Catalina , Marín Mónica Botero , Trujillo Catalina Jaime , Hernández Laura Jimena , Vanegas Melisa Naranjo , Moreno Sergio Mauricio , Rueda-Guevara Paola , Piñeros Juan Gabriel , Baquero Olga , Bonilla Carolina , Mesa María Lucía , Restrepo-Gualteros Sonia , Barrera Pedro , Varela Andrea Ramirez 
Published: April 2023

Abstract
Background: Acute respiratory failure (ARF) is the most frequent cause of cardiorespiratory arrest and subsequent death in children worldwide, therefore several efforts have been made to better understand its etiology and risk factors for further progression (1–4). The aim of this study was to calculate mortality and describe associated factors for severity and mortality in children with acute respiratory failure.
Methods: The study was conducted within a prospective multicentric cohort that evaluated the natural history of pediatric acute respiratory failure (ARF). For this analysis three primary outcomes were studied: mortality, invasive mechanical ventilation, and pediatric intensive care unit length of stay.
Setting: Pediatric emergency, in-hospital, and critical care services in three hospitals in Bogotá, Colombia, from April 2020 to June 2021.
Patients: Eligible patients were children older than 1 month and younger than 18 years of age with respiratory difficulty at time of admission. Patients who developed ARF were followed at time of ARF, 48 hours later, at time of admission and at 30 and 60 days after discharge.
Measurements and main results: Out of a total of 685 eligible patients, 296 developed ARF for a calculated incidence of ARF of 43.2%. Of the ARF group, ninety patients (30.4%) needed orotracheal intubation, for a mean of 9.57 days of ventilation (interquartile range = 3.00–11.5). Incidence of mortality was 6.1% (n= 18). The associated factors for mortality in ARF were a history of a neurologic comorbidity and a higher fraction of inspired oxygen at ARF diagnosis. For PICU length of stay associated factors were age between 2 and 5 years of age, exposure to smokers, and respiratory comorbidity. Finally, for mechanical ventilation, the risk factors were obesity and being unstable at admission.
Conclusions: ARF is a common cause of morbidity and mortality in children. Understanding the factors associated with greater mortality and severity of ARF might allow earlier recognition and initiation of prompt treatment strategies.
Anesthesia management in elderly critically ill plateau area patients with severe craniocerebral injury caused by foreign body invasion: a case report
Authors: Sun Yongtao , Liu Yang , Liu Peng , Zhang Min , Liu Mengjie , Wang Yuelan 
Published: April 2023

Abstract
Background: Anesthesia management in elderly patients with long-term invasive plateau area severe craniocerebral injury is complex, rare, and high-risk.
Case: A 76-year-old male had a 26-year history of skull foreign body penetration and 20 days of local pus and pain. His diagnoses included right hypoplasia, a foreign body in the skull with infection, hypokalemia, hypoproteinemia, pulmonary fibrous foci, and bilateral pleural effusion. For almost six months, the patient suffered from recurring headaches, blurred vision, and sluggish movement. The patient had poor diet, and poor sleep quality. The right anterior ear had a 2 cm skin defect with yellow pus and a black metal foreign body tip. The left eyelid was red and swollen, and the left conjunctiva was hyperemic. The right eyelid showed no abnormality with light and adjustment reflexes.
Conclusion: To ensure the patient safety, close multidisciplinary collaboration, a precise surgical plan and anesthetic management strategy are essential.
Electronic Integrated Management of Childhood Illness (eIMCI): a randomized controlled trial to evaluate an electronic clinical decision-making support system for management of sick children in primary health care facilities in South Africa
Authors: Horwood Christiane , Haskins Lyn , Mapumulo Sphindile , Connolly Catherine , Luthuli Silondile , Jensen Cecilie , Pansegrouw Deirdre , McKerrow Neil 
Published: April 2023

Abstract
Background

Electronic clinical decision-making support systems (eCDSS) aim to assist clinicians making complex patient management decisions and improve adherence to evidence-based guidelines. Integrated management of Childhood Illness (IMCI) provides guidelines for management of sick children attending primary health care clinics and is widely implemented globally. An electronic version of IMCI (eIMCI) was developed in South Africa.

Methods

We conducted a randomized controlled trial comparing management of sick children with eIMCI to the management when using paper-based IMCI (pIMCI) in one district in KwaZulu-Natal. From 31 clinics in the district, 15 were randomly assigned to intervention (eIMCI) or control (pIMCI) groups. Computers were deployed in eIMCI clinics, and one IMCI trained nurse was randomly selected to participate from each clinic. eIMCI participants received a one-day computer training, and all participants received a similar three-day IMCI update and two mentoring visits. A quantitative survey was conducted among mothers and sick children attending participating clinics to assess the quality of care provided by IMCI practitioners. Sick child assessments by participants in eIMCI and pIMCI groups were compared to assessment by an IMCI expert.

Results

Self-reported computer skills were poor among all nurse participants. IMCI knowledge was similar in both groups. Among 291 enrolled children: 152 were in the eIMCI group; 139 in the pIMCI group. The mean number of enrolled children was 9.7 per clinic (range 7–12). eIMCI consultations took longer than pIMCI consultations (median duration 28 minutes vs 25 minutes; p = 0.02). eIMCI participants were less likely than pIMCI participants to correctly classify children for presenting symptoms, but were more likely to correctly classify for screening conditions (TB, HIV and nutrition). However, this did not increase identification of children who screened positive. eIMCI participants were less likely to provide all required medications (124/152; 81.6% vs 126/139; 91.6%, p = 0.026), and more likely to prescribe unnecessary medication (48/152; 31.6% vs 20/139; 14.4%, p = 0.004) compared to pIMCI participants.

Conclusions

Implementation of eIMCI failed to improve management of sick children, with poor IMCI implementation in both groups. Further research is needed to understand barriers to comprehensive implementation of both pIMCI and eIMCI. (350)
Clinical Trials Registration: BFC157/19
3D bright-bright Peregrine triple-one structures in a nonautonomous partially nonlocal vector nonlinear Schr¨odinger model under a harmonic potential
Authors: Li Jitao , Yang Jing , Zhu Yu , Qin Wei , Wang Shaohui 
Published: April 2023

Abstract
Similar dynamical properties of coupled solitons have been heavily reported in previous literatures. This paper focuses on the different excitation management of two components for 3D bright-bright Peregrine triple-one structures in a nonautonomous partially nonlocal vector nonlinear Schr¨odinger model under a harmonic potential by contrasting the maximum accumulated time value with the the excited value for each Peregrine peak. Furthermore, the different diffraction values in two transverse directions affect the bright-bright Peregrine triple-one structure configurations and amplitude and width of the Peregrine structure. This study extends the management of rogue wave to the partially nonlocal phenomena of optical wave, matter wave and other nonlinear waves.
Design and fabrication of a potential biodetector based in gold nanoantennas array
Authors: Moreno Juan R. , Chiwo F. S. , Cabrera-Alonso R. , Aboytes-González JA. , Rosa-Zapata Ariel de la , de Leon Ramón Diaz , Garduño I. E. , González Francisco J. , Mendez-Lozoya Javier 
Published: April 2023

Abstract
The biotechnology sector is focusing on developing biosensors that allow us to detect and monitor substances in vivo using non-invasive methods. For example, in substances detection using the label-less method, radiation in the mid-infrared (mid-IR) has been used to obtain the vibrational fingerprint. In this work, we propose to use plasmonic nanoantennas called spaceship to develop a SEIRA substrate that can be used in disease detection. The spaceship nanoantennas were fabricated using electron beam lithography. A potential SEIRA device was fabricated with Au spaceship nanoantennas based on crop circles with dimensions of 5.5 µm long and 5 µm high. The resonance frequency (νres) was analyzed using gold nanoantennas absorbance as a function of frequency where one peak wasfound at 33THz. Additionally, these results were corroborated with a simulation where the magnitude of the electric field E = 7.79 V/m at 30.02 THz was found, and in E = 3.42 V/m at 79.97 THz is shown. These results allow us to propose spaceship nanoantennas as good candidates for the design of a SEIRA substrate.
Psychometric evaluation of nursing interns' Consciousness of Rights Scale in clinical practice
Authors: Zeng Yuting , Li Hongyu 
Published: April 2023

Abstract
OBJECTIVE: The purpose of this study was to translate the Awareness of Rights Scale into Chinese and test its psychometric properties among nursing students in clinical practice
METHODS: The original English scale was translated, synthesized, and back-translated according to the Brislin translation model: the translated scale was cross-culturally adapted through expert correspondence and pretesting to form the Chinese version of the scale; a convenience sampling method was used to survey 506 nursing interns in Liaoning, Guangdong, and Anhui regions to assess the reliability and validity of the scale.
RESULTS: The Chinese version of the scale consists of 14 items in three dimensions. The Cronbach's alpha value of the scale was 0.916 and the range of Cronbach's alpha coefficients was 0.768 to 0.894. The discounted half reliability was 0.867 and the retest reliability was 0.901. The scale content validity index (S-CVI) was 0.963. A total of three common factors were extracted for the exploratory factor analysis. The validated factor analysis indices fit well (χ2/df = 1.092, RMSEA = 0.014, CFI = 0.998, IFI = 0.998. TLI = 0.997), and the model fit was good.
CONCLUSION: The Chinese version of the scale has good reliability and validity in the nursing intern population and can be used to assess nursing interns' awareness of their rights in clinical practice in mainland China.
Discovery and Exploration of Monosaccharide Linked Dimers of Galectin-3 Inhibitors to Target Fibrosis
Authors: Swidorski Jacob J. , Beno Brett R. , Liu Chunjian , Yoon David S. , Ghosh Kaushik , Sale Harinath , Shah Devang , Acharya Kriti , Yanchunas Joseph , Haldar Priyanka , Kalidindi Narasimharaju , Shukla Jinal K. , Argentieri Matthew , Ellsworth Bruce A. , Cheng Dong , Regueiro-Ren Alicia 
Published: April 2023

Abstract
Galectin proteins have been targets of interest in numerous therapeutic areas for some time. Galectin-3 has been identified as a target of particular interest because of its unique structural characteristics and physiological profile. Recent literature indicates Gal-3 inhibition can decrease myofibroblast activation and procollagen expression with the potential to affect the progression of fibrosis in the lung, liver and kidney. Potential π-stacking interactions between one monosaccharide ligand bound to the carbohydrate recognition domain of a galectin-3 protein and a second ligand bound to a different galectin-3 protein molecule were observed in the extended crystalline lattice in an X-ray crystal structure obtained while studying the monosaccharide structure-activity relationship. The direct interaction between the ligands suggests a potential for dimeric galectin-3 inhibitors which bind to two galectin-3 molecules simultaneously. This work describes the exploration of dimers designed to further probe these observations and explore the potential of binding to dimeric or higher order multimeric galectin-3 assemblies.
The association between team job crafting and work engagement among nurses: a prospective cohort study
Authors: Iida Mako , Sakuraya Asuka , Watanabe Kazuhiro , Imamura Kotaro , Sawada Utako , Akiyama Hiroto , Komase Yu , Miyamoto Yuki , Kawakami Norito 
Published: April 2023

Abstract
Background
Team-level job crafting has been put forward as a method to promote nurses' mental health. However, a longitudinal association is unclear. Therefore, the objective of this study was to investigate the association between team job crafting at baseline and work engagement, work performance, psychological distress, and intention to leave at three-month and six-month follow-ups among Japanese hospital nurses. Also, whether an increase in the team job crafting during 3 or 6 months was associated with an increase in the work engagement during 3 or 6 months of individual nurses was examined.
Methods
A multilevel prospective cohort study was conducted. Data were collected from nurses of five hospitals in Japan at baseline (T1) and follow-ups at 3-months (T2) and 6-months (T3). A total of 2,478 nurses were included. The team job crafting scale for nurses and its three subscales were measured for the independent variables. Ward-means were used as ward-level variables. The dependent variables were work engagement, work performance, psychological distress, and intention to leave. Hierarchical Linear Modeling (HLM) was used to examine the multilevel association.
Results
Data from 391 nurses nested in 30 wards were included in the analyses. The intraclass correlation coefficients (ICCs) at T1 were 0.02 for work engagement and 0.07 for team job crafting. The HLM revealed that ward-level team job crafting at T1 was not significantly associated with work engagement, work performance, psychological distress, and intention to leave at T2 or T3. The ward-level change (T3-T1) of “crafting for the task considering the team’s growth” (subscale for team job crafting) was significantly and positively associated with the change (T3-T1) in work engagement.
Conclusions
Ward-level team job crafting at baseline did not predict nurses' work engagement at the follow-ups. This finding contradicted previous cross-sectional and one-month follow-up studies in other countries. The impact of ward-level team job crafting on work engagement may be limited to more than a three-month follow-up.
Inquiry - Based Learning: Its Impact to Students Problem Solving Performance in Series
Authors: Chengay Frederick B. 
Published: April 2023

Abstract
This study sought to determine whether the use of Inquiry-Based Learning (IBL) approach have an effect on the performance of students in solving word problems under series. It aimed to answer the following problems: 1) What is the level of performance of students in solving word problems when exposed to Inquiry – Based Learning approach and traditional approach? 2) What is the difference in the students’ level of performance in solving word problems when compared according to teaching approach their exposed to? 3) What are the coping mechanisms of students in solving word problems?
Matched pairs design was used in this study. Sixty (60) grade 10 students of Baguio City National High School-Hillside Annex during the school year 2017 – 2018 were the respondents of the study. Data were obtained through a survey questionnaire along with a teacher-made test in word problem.
Results revealed that students taught using the IBL approach registered a higher performance. However, further analysis revealed that there is no significant difference in the students’ level of performance in solving word problems when compared according to teaching approaches their exposed to. This indicates that both approaches have the same effect on the performance of students. Results also show that the coping mechanisms in solving word problems for students exposed to traditional approach was creating a systematic list while looking for a pattern to students exposed to IBL approach.
It is recommended that Mathematics teachers use varied teaching approaches such as IBL approach in teaching word problems to improve better performance of students. Also, more trainings and workshops should be conducted for the teachers to master the proper and effective use of IBL approach. This will enable them to deliver the lesson in a more creative, enjoyable and effective way. In addition, teachers may consider discussing the different strategies of solving word problems. Finally, similar study can be conducted in other topics in Mathematics and to consider other variables to verify results.
Investigation of Etiology of Community-Acquired Pneumonia in Hospitalized Patients in a tertiary hospital of São Paulo City, Brazil
Authors: Joelsons Daniel , Alencar Cecília Salete , Pinho João Renato Rebello , Ho Yeh-Li 
Published: April 2023

Abstract
Background Community-acquired pneumonia (CAP) is the primary cause of hospitalization in the United States and the third leading cause of death in Brazil. The gold standard for diagnosing the etiology of CAP includes blood culture, Gram-stained sputum, and sputum culture. However, these methods have low sensitivity. No studies investigating the etiology of CAP have been conducted in Brazil in the last 20 years, and the empirical choice of antimicrobials is mainly based on the IDSA guidelines.Methods The aim of this study is to identify the main microorganisms implicated in CAP by employing a multiplex polymerase chain reaction (mPCR) at the foremost public hospital in Brazil. All patients who were admitted to the emergency department and diagnosed with severe CAP underwent an mPCR panel using nasopharyngeal and oropharyngeal swabs, with the aim of detecting 13 bacterial and 21 viral pathogens.Results A total of 169 patients were enrolled in the study. The mPCR panel identified an etiological agent in 61.5% of patients, with viruses being the most common (42.01%), led by Rhinovirus, followed by Influenza and Coronavirus (non-SARS-CoV-2). Bacterial agents were identified in 34.91% of patients, with S. pneumoniae being the most common, followed by H. influenzae, M. catarrhalis, and S. aureus. Additionally, we found that the prescription for 92.3% of patients could be modified, with most changes involving de-escalation of antibiotics and antiviral therapy.Conclusion Our study revealed different etiological causes of CAP than those suggested by the Brazilian guidelines. Using molecular diagnostic tests, we were able to optimize treatment by using fewer antibiotics.
Contribution of cardiopulmonary ultrasound in monitoring disease progression and curative effect in rat model of monocrotaline-induced pulmonary arterial hypertension
Authors: Zhong Yanfen , Liang Binbin , Zhang Xiaofeng , Li Jingtao , Huang Tongtong , Zeng Deicai , Wu Ji 
Published: April 2023

Abstract
Background: Right ventricle function and pulmonary edema were associated with readmission and mortality in patients with pulmonary arterial hypertension (PAH). We investigated the role of cardiopulmonary ultrasound (CPUS) in monitoring disease progression and curative effect in rat model of monocrotaline (MCT)-induced PAH.
Methods: Totally 64 SD rats were randomly divided to control group, MCT group and PDTC group (pyrrolidine dithiocarbamate). MCT groups and PDTC groups received a single intraperitoneal injection of MCT to induced PAH while control group received same amount of saline. And PDTC groups injected PDTC daily for treatment after modeling. Each group were received CPUS examination and measurement of pulmonary arterial pressure (PAP).
Results: (1) As the PAP increased in the second week after MCT injection, rats had enlarged pulmonary artery(PA) and right atrium(RA), right ventricle(RV) function decreased, pulmonary acceleration time(PAAT) reduced with mid-systolic notching; pleural line and A-line blurred or disappeared, the number of B-line increased and pulmonary ultrasound score also increased ; in the third week, with the disease progressed, rats had enlarged RV, increased RV wall thickness and RV function decreased further; lung consolidation and air bronchogram could be found (both p＜0.05 vs control group). (2) In the second week after PDTC treatment, with the PAP decreased, rats had shrunk PA, RA and RV, RV wall thickness decreased PAAT extended and RV functions elevated; the number of B-line decreased, lung consolidation and pleural effusion were rare and the pulmonary ultrasound score decreased (both p＜0.05 vs MCT-4W group).
Conclusions: In the MCT-induced rat model of PAH, CPUS changes were observed as PAP changed. There was a good correlation between the manifestations of CPUS and the severity of disease. CPUS can play an important role in monitoring the progression and efficacy of PAH, provide more evidence for the management of PAH patients and a non-invasive method in monitoring the establishment of animal models for basic and clinical studies of PAH.