bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Anterior Permanent Dentition in Chinese population via Cone-beam Computed Tomography
Authors: CHEN YU , Lu Bingtai , Dai Yu , You Yuehua , Wu Bin , Yan Zhengbin 
Published: January 2023

Abstract
Purpose
Investigation of roots and canals is crucial in clinical assessment and treatment. Morphologies such as root length, cemento-enamel junction curvature (CEJ-C), root furcation and canal variations are important factors yet remain to be discussed in depth.
Methods
In this retrospective study, we look into 4309 anterior teeth from 401 patients via cone-beam computed tomography (CBCT) in Chinese population, attempting to summarize the morphological characteristics of maxillary and mandibular anterior teeth.
Results
Maxillary and mandibular canines are observed with elevated root length compared with corresponding incisors (p < .0001), while those of mandibular central and lateral incisor varied with significant difference (p < .0001). The CEJ-C reveals significant increasement around incisors than canines in maxilla (p < .0001). Root furcation is detected in mandibular canines and lateral incisors. Moreover, all types of Vertucci’s classification are noticed with two other new types.
Conclusions
The current findings help to optimize the root morphological understanding of Chinese population especially in endodontics. Moreover, CEJ-C facilitates clinical aesthetic interpretation and treatment in implantology and prosthodontic. However, further study should be carried out to investigate morphologies of posterior dentition.
Age-stratified association between plasma adiponectin levels and morality in septic patients
Authors: Wang Hui , Ma Ming , Gao Yan-xiang , Wu Yi-na , Zhai Shan-shan , Li Chen , Duan Jun 
Published: January 2023

AbstractBackground:Plasma adiponectin (APN) levels are might be affected by age. The present study aimed to study the association between plasm APN levels and age, and the effects of APN levels on mortality in different age-stratified septic patients.Methods:The retrospective study that was performed with 173 patients with sepsis and 57 controls. Physical and demographic characteristics were recorded, blood samples were collected to measure plasma adiponectin levels. Using these data, we determined the association between plasma adiponectin levels and age, and the effect of plasma adiponectin levels on mortality in different age-stratified septic patients.Results:Three age group were defined: middle-age patients range of <60years, the old group of 60-80 years, and the elderly group of ≥80years. Plasma adiponectin levels increased with increasing age both in control group and sepsis group. Mortality increased with age: 12.3% in middle-aged patients, 24.6% in old patients, and 36.2% in elderly patients (P<0.001). In middle-age patients and old patients, according to the receiver operating characteristic curve, plasma APN levels had the comparable value in prediction of 28-day mortality. And adiponectin levels were an independent predictive factor for 28-day mortality for patients <80 years. However, in elderly patients, the adiponectin levels showed no significant association with 28-day mortality.Conclusions:A significant positive association between plasma APN levels and age in septic patients were found. Low circulating levels of APN were associated with 28-day mortality in septic patients aged <80years. The association between APN and mortality in sepsis patients aged >80years were not significantly found.
Coral-reefs off North and West Africa – Environmental settings
Authors: Buhl-Mortensen Lene , Houssa Rachida , Bengue B.M. , Nyadjro E , Cervantes D , Idrissi M , Mahu E , Dia AS , Olsen M , Mas C , Chierici M 
Published: January 2023

Abstract
As part of the EAF Nansen Program, three cold-water coral sites have been studied along the West African coast: in Mauritania-Morocco and Ghana/Côte d'Ivoire. The aim was to investigate their health status in contrasting environment to obtain knowledge on the physiological ranges and adaptive capacity to multiple stressors. The used data concerns the landscape, depth, water masses, temperature, dissolved oxygen concentration (DO), carbonate chemistry (pH, aragonite saturation WAr), macronutrients and particles (visual). The results are compared to the health status of other Lophelia pertusa reefs in such contrasting environments. The results show that large healthy reefs of L. pertusa reside off Ghana and Mauritania in the oxygen minimum zone (OMZ) with DO concentrations between 1.1 and 1.6 ml L− 1. They are located in corrosive waters with the lowest pH and WAr and high nutrient levels. The reefs off Morocco reside in waters similar to the Norwegian reefs in well oxygenated waters with oversaturated WAr but was showed to be less healthy (dead) compared to the reefs in the other two sites that resided in the OMZ. This study demonstrates that L. pertusa thrives in OMZ and corrosive aragonite waters, suggesting local adaptation to these conditions and supporting recommendations to continue research work on the same species in contrasting environments for potential effects of climate change.
Sexual Orientation and Study Cycle: Income Differences in Brazil
Authors: Mantovani Gabriela Gomes , Staduto Jefferson Andronio Ramundo 
Published: January 2023

Abstract
This article aims to measure and analyze income disparities and discrimination between homosexuals and heterosexuals in different study cycles (low, medium, and high education) in Brazil. Recentered influence function (RIF) regressions and income decomposition (RIF decomposition) were performed using microdata from the Continuous National Household Sample Survey from two periods (2013 to 2015 and 2016 to 2019). The results show income disparities between homosexuals and heterosexuals. Income differences are different by gender and between both selected periods, although they are greater for highly skilled workers and women. Income decompositions showed that the explained effect was largely responsible for the difference in income between homosexuals and heterosexuals. The counterfactual effects – positive and negative – on the income of homosexuals generated by this effect were higher for men although a pattern of behavior was not found by study cycle or between periods.
JEL codes: J12; J16; J31
Ca &amp; Sbo : A Novel Optimized Placement Algorithms for an Efficient Vlsi Design
Authors: R Pavithra Guru 
Published: January 2023

Abstract
Designing a simplest architecture involves appropriate placement, which is often, regarded as a critical concerns of physical design engineers. Placement and routing of chips in automated manner is been research since decades and provides better predictive performance than manual procedures. However, most of the automated models operating under meta-heuristic optimization fails in obtaining optimal solution due to premature convergence and non-optimal placement of solutions. In this paper, we develop a novel meta-heuristic optimization method namely Cellular Automata (CA) and Satin Bowerbird Optimization (SBO) that combines Primal-dual lagrangian technique (SimPL) and Complex Primal dual lagrangian (ComPL) for attaining optimal placement and routing of chips. The process of CA and SBO optimization approach operates on obtaining optimized placement solutions from the SimPL and ComPL solutions. The combination of CA-SimPL, SBO-SimPL, CA-ComPL and SBO-ComPL is implemented on electronic design automation (EDA) tools with python simulator for pre-training and fine-tuning the optimization model. The simulation is conducted on a high-end computing system to test the computational time speed up ratio on different threads and half-perimeter wire length (HWPL). The results of simulation shows that the proposed models obtain increased performance with reduced computational time than other methods.
The First case of Pseudomonas oleovorans Sepsis in China: a case report
Authors: Liu Junbao , Wang Xingang , Hao Duo , Xie Peitao , Wu Bo , Tian Yixuan , Su Changhai 
Published: January 2023

Abstract
Background

Pseudomonas oleovorans (P. oleovorans) is an environmental isolate and rarely implicated in human infections. The bacterium has been isolated only in one reported case of blood infections. This case report describes the isolation of a rare Pseudomonas bacterium in a patient presenting with sepsis.

Case presentation

A 72-year-old woman was presented to a hospital in the Ordos of China, with a 2-day history of fever, chills, abdominal pain and nausea. P. oleovorans was identified in the patient’s blood culture using the Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS). The patient discharged on piperacillin-tazobactam therapy 3 weeks after admission.

Conclusions

These findings suggest that less common species of Pseudomonas need to be identified accurately. P. oleovorans is a known environmental contaminant and must also be considered as a potential pathogen.
Mnemonic-trained brain tuning to a regular odd-even pattern subserves digit memory in children
Authors: Pan Yafeng , Hao Ning , Liu Ning , Zhao Yijie , Cheng Xiaojun , Ku Yixuan , Hu Yi 
Published: January 2023

AbstractIt is said that our species use mnemonics – that “magic of memorization” – to engrave an enormous amount of information in the brain. Yet, it is unclear how mnemonics affect memory and what the neural underpinnings are? In this electroencephalography study, we examined the hypotheses whether mnemonic training improved processing-efficiency and/or altered encoding-pattern to support memory enhancement. By 22-day training of a digit-image mnemonic (a custom memory technique used by world-class mnemonists), a group of children showed increased short-term memory after training, but with limited gain generalization. This training resulted in regular odd-even neural patterns (i.e., enhanced P200 and theta power during the encoding of digits at even- versus odd- positions in a sequence). Critically, the P200 and theta power effects predicted the training-induced memory improvement. These findings highlight the plasticity of the mnemonic system in the developmental brain, and provide evidence of how mnemonics alter encoding pattern, as reflected in functional brain organization, to support memory enhancement.
UXT-V1 contributes to the malignant phenotypes of colorectal cancer via GSK3β by activating Wnt/β-catenin pathway
Authors: Chen Guanjun , Chen Huili , Xiao Qiaoqiao , Zhou Xinrui , Wang Fei , Chen Shuliang , Yu Xiaolan , Luo Fan , Li Li 
Published: January 2023

Abstract
Background: Colorectal cancer (CRC) is one of malignant tumors that seriously threatening human health. β-catenin is a central hub in Wnt pathway, aberrant activation of Wnt/β-catenin signaling pathway promotes the tumorigenesis/progression of CRC.
Methods and Results: Here we found a β-catenin interactor, UXT-V1, could modulate Wnt signaling. The expression of UXT-V1 mRNA was increased in CRC tissues. Overexpression of UXT-V1 increased the canonical Wnt signaling, as evidenced by Wnt reporter systems and the up-regulation of marker genes including Axin, CyclinD1 and c-Myc. While, knockdown of UXT-V1 impaired the expression of these genes and attenuated Wnt signaling. Mechanistically, overexpression of UXT-V1 could inhibit GSK3β mediated β-catenin phosphorylation and degradation. Knockout of UXT-V1 increased β-catenin phosphorylation, prevented CRC cell growth, and inhibited tumorigenesis in NOD-SCID mice.
Conclusions: Taken together, our findings revealed that UXT-V1 could control Wnt signaling through targeting GSK3β mediated β-catenin phosphorylation and degradation, providing a molecular basis for CRC treatment.
HELP – Heidelberg decision aid for lung cancer patients. A randomized controlled clinical trial
Authors: Deis Nicole , Unsöld Laura , Siegle Anja , Krisam Johannes , Thomas Michael , Villalobos Matthias 
Published: January 2023

Abstract
Background: Shared decision-making (SDM), which increases the patient's well-being, adherence, and the success of treatment, is becoming increasingly important in medicine and especially in oncology. To empower patients to participate more actively in consultations with their physicians, decision aids have been developed. In non-curative settings, such as the treatment of advanced lung cancer, decisions differ substantially from the curative setting, as uncertain gains in terms of survival outcomes and quality of life have to be weighed against severe side-effects of treatment regimens. There is still a lack of tools developed and implemented for such specific settings in cancer therapy that support shared decision-making. The aim of our study is to evaluate the effectiveness of the HELP decision aid.
Methods: The HELP-study is designed as a randomized, controlled, open monocenter trial with two parallel groups. The intervention consists of the use of the HELP decision aid brochure, accompanied by a decision-coaching session. The primary endpoint is clarity of personal attitude as operationalized by the Decisional Conflict Scale (DCS) after the decision-coaching. Randomization will be performed as stratified block randomization according to the characteristic of preferred decision-making at baseline with a 1:1 allocation.
The participants in the control group get usual care, i.e. the doctor-patient conversation takes place without preliminary coaching and deliberation about their preferences and goals.
Discussion: Developing decision aids (DA) for (lung) cancer patients with limited prognosis should empower patients to address these aspects and include information about “Best Supportive Care” as a treatment option. Using and implementing the decision aid HELP can not only give patients the possibility to include their personal wishes and values in the decision-making process, but also raise the awareness of shared decision-making itself among these patients and their physicians.
Trial registration: DRKS00028023 [registered on 8 February 2022]
Lipidomic signature of stroke recurrence after transient ischemic attack
Authors: Purroy Francisco , Ois A , Jove M. , Arque G , Sol J , Mauri-Capdevila G , Campello A. Rodriguez , Pamplona R , Portero M , Roquer J 
Published: January 2023

Abstract
Objective
To find new biomarkers of early stroke recurrence (SR) by using lipidomic strategies on patients who suffered a transient ischemic attack.
Methods
Untargeted lipidomic analysis was performed in plasma samples of 460 consecutive TIA patients. Recruited < 24 hours after the onset of symptoms.
Results
SR at 90 days follow-up was showed by 37 (8%) patients. In Cox proportional hazards models previous ischemic stroke (95%CI, 1.07–5.75), motor weakness (95%CI, 1.14–4.98), large-artery atherosclerosis (95%CI, 1.20–5.23) and female sex (95%CI, 1.31–5.46) were predictors of SR. Lipidomic profiling disclosed specific SR biomarkers: 7 lipid species differentially expressed between groups. Interestingly, 6 of these 7 lipid species belonged to the glycerolipid family and the other one is a plasmalogen, pointing to bioenergetics pathways, as well as oxidative stress response. Indeed, the detected lipid set express a condition of impaired response to energy supply and stress in SR patients compared to TIA non-SR patients. In this context, it is proposed the PE(P-18:0/18:2) as potential biomarker of SR condition.
Conclusion
the lipidomic profiles of TIA subjects with non-SR and SR were different, with minor but significant changes. The observed changes in lipid patternssuggest pathophysiological mechanisms associated with the different formation of lipid droplets that is translated to plasma level as consequence of a more intensive or high-risk ischemic condition related to early SR.
Blockchain and Mobile Client Privacy Protection in E-Commerce Consumer Shopping Tendency Identification Application
Authors: Liu Ruiqian , Wang Enjiang 
Published: January 2023

Abstract
In recent years, China's e-commerce has made great progress, and the growth trend of online shopping is obvious. Although China's online sales are far below half of the United States. One of the important reasons is the privacy risks of e-commerce and insufficient consumer trust, but it still hinders the development of e-commerce online shopping applications. According to the trust survey, interaction is an important condition for generating trust and an important element. However, in the existing e-commerce trust surveys, the impact of interaction is analyzed, but few surveys only have an impact on consumers' shopping tendency. Therefore, considering the importance of the reliability of e-commerce online shopping applications and the current issues related to consumer privacy protection between the blockchain and mobile clients, on this basis, through theoretical analysis and empirical research, consumers The influence of platform-type shopping websites on reliability and consumer shopping behavior factors and mechanisms, blockchain and mobile client privacy protection design investigation and verification forms. The shopping direction identification system of e-commerce consumers has to some extent made up for the shortcomings of previous empirical research on e-commerce trust behavior. In the field of consumer research, e-commerce has the importance of becoming a specific practical indicator.
On the stability of pairs of subharmonic centrifugal pendulum vibration absorbers allowing a rotational mobility
Authors: MAHE Vincent , Renault Alexandre , Grolet Aurélien , Mahé Hervé , Thomas Olivier 
Published: January 2023

Abstract

Centrifugal pendulum vibration absorbers (CPVAs) are passive devices used to reduce torsional vibrations in rotating machines. Previous works showed that a CPVA configuration with two pendulums oscillating in phase-opposition and at half the excitation frequency is efficient in reducing the rotor's vibrations. This paper deals with a new generation of CPVAs, in which the pendulums admit a rotational motion relative to the rotor in addition to the traditional translational motion. The aim of this study is to assess the dynamic stability of a particular subharmonic solution of CPVAs composed of several pairs of pendulum. To do so, a new method based on an analytical perturbation technique is proposed. It leads to more general conclusions than previous studies as the results are derived for CPVAs with any even number of pendulums. The validity of the analytical model is confirmed through a comparison with a numerical resolution of the system's dynamics, and new design guidelines are proposed.
An unusual case of hump-nosed-viper bite complicated with venom-induced thrombotic thrombocytopaenic purpura
Authors: Semina Thisal , Silva Shehan 
Published: January 2023

Abstract
Background: Hump-nosed-viper bites are common in Sri Lanka resulting in nephrotoxicity and coagulopathy. Venom induced consumptive coagulopathy (VICC) is a known complication which occurs in absence of nephrotoxicity.
Case Presentation: We report a case of hump-nosed-viper bite complicating with venom-induced thrombotic thrombocytopenic purpura (VITTP) of a 49 years old previously healthy male. Following envenomation, he developed anuria with acute kidney injury. The blood picture showed microangiopathic haemolytic anaemia with thrombocytopenia while the clotting profile was normal. A plausible diagnosis of VITTP was made per a high PLASMIC score (6/7). The patient underwent therapeutic plasma exchange (TPE) followed by high dose steroids along with renal replacement therapy. He made a full recovery.
Conclusion: VITTP is a manifestation that needs to be differentiated from VICC in hump-nosed-viper bites.
Circularity of resources in the craft brewery segment: an analysis supported by innovation
Authors: Julkovsky Dulcimar José , Sehnem Simone , Lara Ana Claudia , Ramos Maria da Conceição Pereira , Hermann Roberto Rivas 
Published: January 2023

Abstract
This article analyzes how the circularity of resources occurs in Brazilian craft breweries supported by innovation and proposes the creation of alternative craft breweries to promote circular economy. Data were collected through 11 interviews with entrepreneurs in the craft brewery segment, checklist application, and access to the website of the cases investigated. Our results expand the relationship with innovation suggesting that: a) the circularity of resources is still focused on several long-cycle practices; b) short cycles, which are the most desired for the retention of resource value in the production chain, are already present, but demand more attention from the enterprises surveyed; c) innovation practices can become barriers to or drivers for the feasibility of circular economy in the beer context; d) technical cycles are consolidated in most of the researched cases, while biological cycles still demand greater engagement from all stakeholders; e) the nature and content of circular practices imply different adoption stages in the cases investigated; f) companies invest in strengthening the relationship with consumers and suppliers in order to obtain support for current circular strategies in their ventures.
Identification of Hub Genes and Potential ceRNA Networks of Diabetic Cardiomyopathy
Authors: Hou Jun , Liang Wan Yi , Xiong Shiqiang , Long Pan , Yue Tian , Wen Xudong , Deng Haoyu 
Published: January 2023

Abstract
Introduction: Diabetic cardiomyopathy (DCM), a common complication of diabetes, is defined as ventricular dysfunction in the absence of underlying heart disease. Noncoding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), play a crucial role in the development of DCM.
Methods and Results: Weighted Gene Co-Expression Network Analysis (WGCNA) was used to identify key modules in DCM-related pathways. DCM-related miRNA-mRNA network and DCM-related ceRNA network were constructed by miRNA-seq to identify hub genes in these modules.
Results: we identified five hub genes that are associated with the onset of DCM, including Troponin C1 (Tnnc1), Phospholamban (Pln), Fatty acid binding proteins 3 (Fabp3), Popeye domain containing 2 (Popdc2), and Tripartite Motif-containing Protein 63 (Trim63). miRNAs that target the hub genes were mainly involved in TGF-β and Wnt signaling pathways. GO BP enrichment analysis found these miRNAs were involved in the signaling of TGF-β and glucose homeostasis. QCR results found the gene expressions of Pln, Fabp3, Trim63, Tnnc1, and Popdc2 were significantly increased in DCM.
Conclusion: Our study identified five hub genes (Tnnc1, Pln, Fabp3, Popdc2, Trim63) whose associated ceRNA networks are responsible for the onset of DCM.
Analysis of the correlation between climatic variables and Dengue cases in the city of Alagoinhas/BA
Authors: Batista Figuredo Marcos , Souza Monteiro Roberto Luiz , Nascimento Silva Alexandre , de Araújo Fontoura José Roberto , da Silva Andreia Rita , Pereira Alves Carolina Aparecida 
Published: January 2023

Abstract
The Aedes aegypti mosquito is the main vector of dengue and is an extremely synanthropic insect and due to its anthropophilic nature, it has specific reproductive needs. In addition to that, it also needs tropical regions that provide climate-prone conditions that favor vector development. In this article, we propose the cross-correlation analysis between the climatic variables air temperature, relative humidity, weekly average precipitation and dengue cases in the period from 2017 to early 2021 in the municipality of Alagoinhas, Bahia, Brazil. To do so, we apply the trend-free cross-correlation, $\rho DCCA$, being a generalization of the fluctuation analysis without trend, where we calculate the cross correlation between time series to establish the influence of these variables on the occurrence of dengue disease. The results obtained here were a moderate correlation between relative humidity and the incidence of dengue cases, and a low correlation for relative air temperature and precipitation. However, the predominant factor in the incidence of dengue cases in the city of Alagoinhas is relative humidity and not air temperature and precipitation.