bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability and Hopf Bifurcation Analysis of a Fractional-order p53 Multiple Time Delays Model under PDα control
Authors: wang danni , yang hongli , yang liangui 
Published: January 2023

Abstract
This paper focuses on the analysis of multiple types of time delays and fractional-order proportional-derivative (PDα) controller on the dynamics of fractional-order p53 model. The multiple types of time delay schemes are dexterously designed during the bifurcation control for the proposed system, and the comparative study is elaborately performed on bifurcation control theoretically. Analysis reveals that the negative feedback delay restrains the delay threshold, while the positive feedback delay promotes the delay threshold and makes the system more robust. System dynamics is affected by fractional order, which is more conducive to the generation of system oscillations. We have adapted control system techniques and designed a PDα controller. This controller is used to activate p53 protein. Numerical results display that the addition of PDα controller can increase the richness of the dynamic system. The differential gain parameter kd of PDα controller promotes the appearance of oscillation, and the proportional gain parameter kp will hinder the appearance of oscillation. The PD controller is a good strategy to control the oscillation behaviors of the system.
On the evolution of metal-bonded microgrinding tool topography due to wear
Authors: Singh Anandita , Singh Ritesh K. , Singh Ramesh K. , Mote Rakesh G. 
Published: January 2023

Abstract
The key challenge in the analysis of the grinding process involves the characterization of tool topography due to a large degree of randomness in the grit shapes, sizes, orientation and distribution. The effect of random tool topography on the output characteristics is even more pronounced in microgrinding. During the process, the wear of bond and grits cause the exposure of the underlying grits of the multi-layered metal bonded microgrinding tools. Due to the random tool topography and its variation during grinding due to continuous wear and self-dressing makes the process analysis highly complex. This study proposes a model that characterizes the multi-layered metal bonded microgrinding tool topography and its evolution during the process caused due to wear. The effects of both grit and bond wear on topography evolution is investigated. The emergence of new grits due to bond wear during the tool-workpiece interaction has also been captured in the model. Individual grit life cycle has been analyzed and the number of protruding, active, dislodged and worn out grits at a given machining time is estimated. Statistical analysis of the protrusion height distribution is carried out which gives an insight into the effect of wear on the height distribution variation.
WAASB-based stability analysis and validation of resistance sources to Plasmopara halstedii race-100 from the sunflower working germplasm for the semi-arid regions of India
Authors: Dudhe Mangesh Yuwaraj , Dudhe M.Y. , Jadhav M.V. , Sujatha M. , Meena H.P. , Rajguru A.B. , Gahukar S.J. , Ghodke M.K. 
Published: January 2023

Abstract

In sunflower, stable performance in a semi-arid region is an essential factor for obtaining high and stable seed as well as oil yield. Therefore, efforts were made to evaluate 28 sunflower genotypes including USDA, USA, France collection and germplasm maintained at ICAR-IIOR, Hyderabad under four semi-arid locations of India during 2021–2022. Screening of the selected genotypes for Sunflower Downy Mildew (SDM) which is important disease and cause losses upto 100% incited by Plasmopara halstedii race-100 in India was undertaken during previous years (2017-20) and validation experiment was conducted during 2021. WAASB (Weighted Average of Absolute Scores) and Multi-Trait Stability Index (MTSI) adopted for stability analysis. The analysis of variance from AMMI showed highly significant effects of the climate, genotypes, and their interaction. Only 56.13% which is lesser than 60% of total GEI variation was explained by first two PCs indicating the complexity of GEI and suitability of WAASB statistics. Based on WAASB study most stable genotypes identified for yield were GMU-494, LTRR-341, EC-601901 and GMU-481and GMU-494 for oil content. Based on WAASBY scores most stable genotype identified for yield were GMU-770 (96.76) and EC-178168-2 (96.53) and for oil content GMU-481(93.64), EC-601901(91.30). Simultaneous selection index MTSI has been employed for selecting high yielding genotypes with medium to high oil content. MTSI index identified ideal genotype EC-198078 which is closer to hypothetical ideotype with least MTSI index coupled with high WAASBY score and resistant reaction to SDM. Population structure based on 20 SSR markers depicted the change of Delta (k) value (k = 4) which suggests the four populations within the collection of 28 sunflower germplasm accessions. Based on multiple year screening we have identified and validated 10 resistance sources and three new sources of resistance to SDM for semi-arid region. Identified stable genotypes coupled with SDM resistance could be useful for the development of inbreds or can be used to develop superior populations in sunflower.
Enhancement of YKL40,IL-6,IL-8, TNF-a, and the possible mechanism of YKL40 promoting overexpression of IL-6,IL-8, TNF-a in childhood with obstructive sleep apnea syndrome
Authors: Wang Yingge , Lin Chang , Huang Min , Fang Xiuling , Chen Guohao , Ye Shengnan 
Published: January 2023

Abstract

Objective
To evaluate the levels of YKL40, IL-6(interleukin-6), IL-8(interleukin-8), IL-10(interleukin-10), TNF-a (tumor necrosis factor-α) in OSAS (obstructive sleep apnea syndrome )children and explore the mechanism of YKL40 promoting inflammatory factors overexpression in tonsils.
Methods
qPCR and ELISA were used to identify the expression of YKL40, IL-6, IL-8, IL-10, and TNF-a in the tonsils of OSAS children. Primary tonsil lymphocytes (PTLCs) were cultured and recombinant human YKL40(rhYKL40)was used to stimulate PTLCs in different concentrations and time points. The activation of NF-κb in PTLCs was observed by western blotting.
Results
Relative mRNA of YKL40, IL-6, IL-8, TNF-α was overexpression in OSAS-derived tonsil tissue and the levels of YKL40, IL-6, IL-8, and TNF-α increased in OSAS-derived tonsil protein supernatant.The relative mRNA expression of IL-6, IL-8 and TNF-α were increased under the treatment of YKL40 (100 ng/mmol for 24h). The phosphorylation of NF-κb p65 was stimulated in the process.
Conclusion
The levels of YKL40, IL-6, IL-8, and TNF-α increased in OSAS children, and YKL40 may promote the overexpression of IL-6, IL-8 and TNF-α in PTLCs via NF-κb pathway. This result indicates that inflammation may play an important role in the pathogenesis of OSAS in children. Inhibition of YKL40 may have a potential therapeutic target for YKL40-induced inflammation in pediatric OSAS.
Aquaporin 9 is involved in CRC metastasis through DVL2-dependent Wnt/βcatenin signaling activation
Authors: Liu Yiting , Feng Xingzhi , Chen Guanxing , Jiang Xuefei , Ye Shubiao , Chen Daici , Yang Zihuan 
Published: January 2023

Abstract
Background: Aquaporin 9 (AQP9), an aquaporin protein family member, is permeable to water and other small molecules. Aquaporins play important role in a variety of pathophysiological processes, fostering growing interests in identifying them as diagnostic and therapeutic targets in cancer. We previously found that AQP9 is related to the efficacy of chemotherapy in CRC patients, but its role and regulating mechanism in CRC progression remains unclear.
Results: In this study, we find that AQP9 is highly expressed in metastatic CRC. AQP9 overexpression induces reduced cell roundness and enhanced cell motility in CRC, which contribute to cancer metastasis. We further show that AQP9 interacts with DVL2 via the C-terminal SVIM motif, resulting in DVL2 stabilization and nuclear β-catenin increase. Deletion of the SVIM motif disrupts the AQP9-DVL2 interaction and results in the repression of TCF/LEF transcriptional activity, supporting the involvement of DVL2 in AQP9 induced Wnt/β-catenin pathway activation. Additionally, we identify the E3 ligase NEDD4L as an modulator in regulating the ubiquitination and degradation of AQP9.
Conclusions: Collectively, our study reveals the important role of AQP9 in regulating DVL2 stabilization and Wnt/β-catenin signaling to promote CRC metastasis. Targeting NEDD4L-AQP9-DVL2 axis might be with therapeutic usefulness in metastatic CRC treatment.
Total Synthesis of Tetrodotoxin and 9-epiTetrodotoxin
Authors: Qi Xiangbing , Chen Pei-hao , Wang Jing , Wang Yan , Sun Yuze , Bai Songlin , Wu Qingcui , Zhang Shuangfeng , Cheng Xinyu , Cao Peng 
Published: January 2023

Abstract
Tetrodotoxin and congeners are specific voltage-gated sodium channel blockers that exhibit remarkable anesthetic and analgesic effects. Here, we present a scalable asymmetric synthesis of TTX and 9-epiTTX from the abundant chemical feedstock furfuryl alcohol. The optically pure cyclohexane skeleton was assembled via a stereoselective Diels-Alder reaction. The dense heteroatom substituents were established sequentially by a series of functional group interconversions on highly oxygenated cyclohexane frameworks, including a chemoselective cyclic anhydride opening, and a decarboxylative hydroxylation. An innovative SmI2-mediated concurrent fragmentation, an oxo-bridge ring opening and ester reduction followed by an Upjohn dihydroxylation delivered the highly oxidized skeleton. Ruthenium-catalyzed oxidative alkyne cleavage and formation of the hemiaminal and orthoester under acidic conditions enabled the rapid assembly of TTX, anhydro-TTX, 9-epiTTX, and 9-epi lactone-TTX.
A Low-Cost Indoor Navigation and Tracking System Based on Wi-Fi-RSSI
Authors: Aminah Nina Siti , Ichwanda Arsharizka Syahadati , Djamal Daryanda Dwiammardi , Budiharto Yohanes Baptista Wijaya , Budiman Maman 
Published: January 2023

Abstract

In the recent years, the number of smartphone users has increased dramatically every year. Smartphones produce a variety of services including indoor navigation and tracking using the Received Signal Strength Indicator (RSSI) value of the Wi-Fi (Wireless Fidelity) routers to estimate user position. In this research, we developed a navigation and tracking system using a Fingerprint map and k-Nearest Neighbor (k-NN) algorithm. In that way, we can help the user to go through the nearest path to user destination by using Dijkstra’s algorithm. These features are displayed in the form of an RSSI-based navigation application on an Android smartphone. At the same time, estimated position of user of this navigation app will be sent to server and viewed in a real time website application. This system helps to assist visitors in finding their way in a complex building and at the same time it allows building owners record and analyze visitor movement. One key benefit of the system is its low initial cost. It only utilizes the existing Wi-Fi infrastructure. Experimental results show that this system can reach an accuracy up to 78% and distance errors less than 3 meters.
Growth and Characterization of (Cd-Zn)S (Cadmium Zinc Sulfide) Thin Film Prepared by Chemical Bath Deposition
Authors: Yadu Goverdhan , Verma Lekhram , Chandrakar Vani , Hirwani Lekhram 
Published: January 2023

Abstract
The present paper reported the optical & structural property of the ternary undoped and Lantanium(La) doped Cadmium Zinc Sulfide (Cd-Zn)S, deposited on the glass substrate by using chemical bath deposition(CBD) method. For the deposition of (Cd-Zn)S thin film used high purity cadmium sulphate, (CdSO4) for Cd2+ ion, thiourea (NH2)2SC for S2− ion, Zinc Acetate ZN(CH3COO)2 is source of Zn2+ ion, Ammonia to maintain pH value, EDTA used as complexing agent, For the doping Lanthanum Nitrate (La(NO3)3) used which is the source of La. The outcomes of X-ray Diffraction (XRD), Photoluminescence (PL) Study and Photoconductivity study are reported for prepared sample. The thickness of prepared Undoped sample (Cd-Zn)S is 1.17 µm and the La Doped Sample (Cd-Zn)S:La thickness is 1.12 µm. Absorption edge spectra shows 550 nm & 520 nm for (Cd-Zn)S & (Cd-Zn)S:La respectively and corresponding band gap is 2.12eV & 2.26eV. In the photoconductivity study the ratio of IPC/IDC found to be of the order of 104, PL Spectra shows excitation peak by transition of excitonic level elements. The Phase of the prepared film is tetragonal, hexagonal, cubic and orthogonal which confirm from XRD study.
Description of Static, Dynamic and Perceptual Body Balance in Youth Soccer Players
Authors: Montealegre-Mesa Lina María , Daza Carlos A. Castillo , Castellanos-Ruíz Julialba , Zamuner Fernanda Habechian 
Published: January 2023

Abstract

Objective
To describe the characteristics of static, dynamic and perceptive body balance in professional league youth soccer players.
Method
Descriptive, cross-sectional design.
Context:
Soccer players from the Caldas Soccer League. Manizales-Colombia.
Participants:
40 youth male soccer players with an age range between 17 and 20 years old belonging to the sub-17 and sub-20 categories at the professional level of a nationally recognized club, Manizales-Colombia.
Measurements:
Romberg test to assess static balance. Stability limits test that allows to evaluate the dynamic stability and the displacement of the centers of pressure. Cumberland Ankle Instability Test Questionnaire (CAIT), which is a self-reported outcome questionnaire that rates the level of functional ankle disability.
Results
There are no significant changes between the balance tests eyes open and eyes closed, therefore, there are no significant variations between body balance; greater center of gravity of the right foot compared to the left, which represents less stability of this hemibody; statistical difference between the feet according to the CAIT questionnaire.
Conclusions
For the analysis of balance in soccer players, it is necessary to observe motor control, the functional and physiological component and understand the factors associated with sports practice such as pain, decreased muscle strength, muscle fatigue, disability, among others, which are contemplated through the CAIT questionnaire, thus establishing the measurable balance and perceptive results of the soccer player.
A fully automated hybrid approach to assessing liver fibrosis and necroinflammation on conventional MRI: A multi-center cohort Study
Authors: Zha Jun-hao , Huang Shan , Xia Tian-yi , Chen Zhi-yuan , Zheng Tian-ying , Yu Qian , Zhou Jia-ying , Cao Peng , Wang Yuan-cheng , Tang Tian-yu , Song Yang , Xu Jun , Song Bin , Liu Yu-pin , Ju Shenghong 
Published: January 2023

Abstract
Background & Aims: To develop and validate the CoRC model at conventional MRI for diagnosing clinically significant liver fibrosis (≥ F2) and necroinflammation (≥ G2).
Materials and methods: This retrospective cohort study recruited 537 patients with biopsy-proven liver fibrosis and necroinflammation at center 1 from May 2015 to Aug 2020 and center 2 between Jan 2011 and Jan 2021. 394 patients were randomly allocated into training (n = 276) and internal test (n = 118) cohorts at center 1.. Automated entire liver segmentation used ResUNet-based Human-in-the-Loop approach. Radiomics features were extracted from the mask on fat-suppressed T2-weighted and delayed enhanced T1-weighted images separately. Radiomics signatures were generated using logistic regression. Radiomics-scores and optimal clinical biomarkers as independent risk factors were integrated into the CoRC models in the training cohort with multivariate logistic regression. Models were tested in independent temporal test cohort at center 1 (n = 96) and an external test cohort from center 2 (n = 47). Diagnostic performance was evaluated by area under the curve, calibrations and decision curve analysis.
Results: In the internal, temporal, and external test cohorts, CoRC model 1 yielded AUCs of 0.79, 0.82 , and 0.83 for ≥ F2, meanwhile, CoRC model 2 showed AUCs of 0.86, 0.79, and 0.89 for ≥ G2. ,We compared CoRC models with transient elastography-based liver stiffness measurement (TE-LSM) subgrouply (AUC 0.78 vs.0.79, P = 0.86/0.82 vs. 0.73, P = 0.14 for ≥ F2, whereas 0.88 vs. 0.81, P = 0.16/0.79 vs. 0.74, P = 0.49 for ≥ G2).
Conclusions CoRC models exhibited promising diagnostic performances for ≥ F2 and ≥ G2, which could be a potential alternative when TE-LSM is unavailable.
Risk Factors of Submucosal Invasion in Early Colorectal Cancer
Authors: Wang Tianzheng , He Chiyi , Li Lin 
Published: January 2023

Abstract
Aim

This study aimed to explore the risk factors of submucosal invasion in early colorectal cancer (ECC), so as to provide more accurate treatment strategies for ECC patients.

Methods

We retrospectively enrolled patients with ECC who received endoscopic or surgical treatment at the First Affiliated Hospital of Wannan Medical College, from January 2017 to December 2021. Univariate analysis and multivariate Logistic regression analysis were used to explore the risk factors of submucosal invasion in ECC. We used a receiver operating characteristic (ROC) curve to estimate the predictive value of independent risk factors for the risk of submucosal invasion in ECC.

Results

A total of 109 ECC patients were enrolled, among them, 46 cases (42.20%) with infiltration depth of submucosa were classified as the study group, and the remaining 63 cases without submucosal invasion were classified as the control group. Univariate analysis showed that age ≥ 65 years old, lesion diameter > 1cm, differentiation degree, lesion surface accompanied by erosion or ulceration, redness and bleeding tendency were associated with submucosal invasion of ECC (P < 0.05). Multivariate Logistic regression analysis showed that the moderate or poor differentiation (β = 4.158, odds ratio [OR] = 63.960, 95% confidence interval [CI]:15.149-270.038, P < 0.001), bleeding tendency (β = 2.828, OR = 16.914, 95%CI:1.728-165.553, P = 0.015) were independent risk factors for submucosal invasion with ECC. The area under the ROC curve (AUC) of differentiation degree was 0.871 (95%CI: 0.797–0.945, P < 0.001), the AUC of bleeding tendency was 0.582 (95%CI: 0.471–0.693, P = 0.145), and the AUC of the combined measurements was 0.906 (95%CI: 0.845–0.967, P < 0.001).

Conclusion

Moderate or poor differentiation and bleeding tendency are independent risk factors for submucosal invasion with ECC. The accuracy of combined measurements is higher than that of single measuremnet. Patients with ECC meeting the above conditions should be adequately evaluated before surgery, so as to provide more accurate treatment strategies.
A Bayesian Method for Dam Failure Risk Analysis using Causal Loop Diagrams and Word Frequency Analysis
Authors: Wang Fang , Li Hongen , Sheng Jinbao , Yuan LI , Pan Yuxuan , Zhao Jianguo 
Published: January 2023

Abstract

Earthen dams operate in complex environments where their safety is often affected by multiple uncertain risks. A Bayesian network (BN) is often used to analyze the dam failure risk, which is an effective tool for this issue as its excellent ability in representing uncertainty and reasoning. The validity of the BN model is strongly dependent on the quality of the sample data, making convincing modeling rationale a challenge, which limits its use. There has been a lack of systematic analysis of the dam failure data of China, which further leads to a lack of in-depth exploration of potential associations between risk factors. In this paper, we established a comprehensive database containing various dam failure cases in China. Herein, historical dam failure statistics are used to develop BN models for risk analysis of earthen dams in China. In order to unleash the value of the historical data, we established a Bayesian network through the Causal Loop Diagrams (CLD) based on the nonlinear causal analysis. We determined the conditional probabilities using Word Frequency Analysis (WFA). By comparing with the Bayesian learning results, the modeling method of BN proposed in our study has apparent advantages. According to the BN model established in this paper, the probabilities of dam failure with three damage modes of seepage damage, overtopping and structural instability are 22.1%, 58.1%, and 7.9%, respectively. In addition, we demonstrated how to perform the inference process of the dam failure path. This will provide helpful information for dam safety practitioners in their decision-making process.
Effects of da Vinci robot versus thoracoscopic surgery on body trauma and lymphocyte subsets in lung cancer patients: a propensity score matching study
Authors: Hong Ziqiang , Sheng Yannan , Bai Xiangdou , Cui Baiqiang , Cheng Tao , Lu Yingjie , Wu Xusheng , Jin Dacheng , Gou Yunjiu 
Published: January 2023

Abstract
Objective
To assess the impact of da Vinci robot versus thoracoscopic surgery on body trauma and lymphocyte subsets in lung cancer patients.
Methods
Retrospective analysis of 352 patients with lung cancer treated by minimally invasive surgery completed by the same operator in the Department of Thoracic Surgery, Gansu Provincial People's Hospital from October 2019 to October 2022. The patients were divided into a robotic-assisted thoracic surgery(RATS) group (n = 159) and a video-assisted thoracoscopic surgery group(VATS) (n = 193) according to the surgical procedure. Propensity score matching analysis (PSM) was performed in both groups, and perioperative indicators were recorded. Levels of inflammatory markers (C-reactive protein, CRP; interleukin-6, IL-6) and lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) were measured 1 day before surgery, 1, 3 and 5 days after surgery, respectively. To compare the effects of the two surgical procedures on the trauma and lymphocyte subsets of the patient's organism.
Results
138 patients in each group after PSM. The operative time, intraoperative bleeding, postoperative drainage time, and drainage flow were all lower in the RATS group than in the VATS group, with statistically significant differences (P < 0.05). The levels of CRP and IL-6 increased in both groups after surgery compared with those before surgery, and the increase was less in the RATS group than in the VATS group. Postoperative T-lymphocyte levels were lower in both groups compared with preoperative levels, and T-lymphocyte levels were significantly lower in the VATS group compared with the RATS group (P < 0.05).
Conclusion
Compared with thoracoscopic radical lung cancer surgery, robotic radical lung cancer surgery is clinically superior because it is less invasive, induces less inflammatory response in the body, has faster recovery, and has less suppressive effects on lymphocyte subpopulations.