bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of the integrated fish endocrine disruptor test—Part B: Implementation of thyroid-related endpoints
Authors: Gölz Lisa , Pannetier Pauline , Fagundes Teresa , Knörr Susanne , Behnstedt Laura , Coordes Sara , Matthiessen Peter , Morthorst Jane , Vergauwen Lucia , Knapen Dries , Holbech Henrik , Braunbeck Thomas , Baumann Lisa 
Published: August 2023

Abstract
Given the vital role of thyroid hormones (THs) in vertebrate development, it is essential to identify chemicals that interfere with the TH system. Whereas, among nonmammalian laboratory animals, fish are the most frequently utilized test species in endocrine disruptor research, for example, in guidelines for the detection of effects on the sex hormone system, there is no test guideline (TG) using fish as models for thyroid-related effects; rather, amphibians are used. Therefore, the objective of the present project was to integrate thyroid-related endpoints for fish into a test protocol combining OECD TGs 229 (Fish Short-Term Reproduction Assay) and 234 (Fish Sexual Development Test). The resulting integrated Fish Endocrine Disruption Test (iFEDT) was designed as a comprehensive approach to covering sexual differentiation, early development, and reproduction and to identifying disruption not only of the sexual and/or reproductive system but also the TH system. Two 85-day exposure tests were performed using different well-studied endocrine disruptors: 6-propyl-2-thiouracil (PTU) and 17α-ethinylestradiol (EE2). Whereas the companion Part A of this study presents the findings on effects by PTU and EE2 on endpoints established in existing TGs, the present Part B discusses effects on novel thyroid-related endpoints such as TH levels, thyroid follicle histopathology, and eye development. 6-Propyl-2-thiouracil induced a massive proliferation of thyroid follicles in any life stage, and histopathological changes in the eyes proved to be highly sensitive for TH system disruption especially in younger life stages. For measurement of THs, further methodological development is required. 17-α-Ethinylestradiol demonstrated not only the well-known disruption of the hypothalamic–pituitary–gonadal axis, but also induced effects on thyroid follicles in adult zebrafish (Danio rerio) exposed to higher EE2 concentrations, suggesting crosstalk between endocrine axes. The novel iFEDT has thus proven capable of simultaneously capturing endocrine disruption of both the steroid and thyroid endocrine systems. Integr Environ Assess Manag 2024;20:830–845. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Effect of re‐cryopreservation on pregnancy and neonatal outcomes: Analysis using propensity score matching
Authors: He Tingting , Xue Xia , Shi Juanzi 
Published: August 2023

AbstractObjectiveTo comprehensively assess the effect of re‐cryopreservation procedure on pregnancy and neonatal outcomes by using propensity matching (PSM) analysis.MethodsThe patients were divided into two groups according to the times of embryo cryopreservation: the cryopreservation group (n = 8034) and the re‐cryopreservation group (n = 66). To optimize the precision of the present study, we used PSM to adjust the different baseline characteristics between the two groups, including maternal age, the number of good‐quality embryos transferred and endometrial preparation protocols. The primary outcome was live‐birth rate. The secondary outcomes were biochemical pregnancy rate, clinical pregnancy rate, and miscarriage rate.ResultsWe found that the rates of biochemical pregnancy and clinical pregnancy were comparable between the two groups, whereas miscarriage rate was increased, resulting in significantly reduced live‐birth rate in the re‐cryopreservation group. No differences were observed in terms of neonatal outcomes, including cesarean section, birth weight, and malformation as well as pregnancy complications. Moreover, multivariable analysis demonstrated that re‐cryopreservation was an independent risk factor for live‐birth rate.ConclusionThe present study demonstrated the adverse effect of re‐cryopreservation on pregnancy outcomes, providing valuable information for clinical decision making and patient counseling.
A multicenter study of the relationship between the compulsory time spent at home and sexual functioning
Authors: Topcu Elif Goknur , Okumus Zihniye Gonca , Terzioglu Merve 
Published: August 2023

AbstractObjectiveTo investigate how sexual life is affected by the increase in the amount of time spent at home due to the restrictions of the coronavirus disease 2019 (COVID‐19) pandemic, and the relationships among depression, anxiety, amount of stress, and sexuality.MethodsThis cross‐sectional study was conducted in two cities, Istanbul (metropolitan city) and Rize (city in a rural area). All data were collected face to face in the gynecology outpatient clinics from patients who came in for benign gynecologic reasons or a check‐up. The questionnaire comprised a sociodemographic form, the Arizona Sexual Experience Scale (ASEX) Scale, and the Depression Anxiety Stress Scale.ResultsA total of 459 participants took part in the study. Around half of the participants were living in an urban area. There was a statistically significant increase in weekly sexual intercourse frequency for both groups. Sexual desire and arousal scores were significantly higher in the rural groups. There was a significant decrease in sexual pleasure within urban groups. Depression, anxiety, and stress scores were significantly higher in urban groups. There was no statistically significant difference in ASEX total scores between groups.ConclusionsThis study suggests that even though the rate of COVID‐19 and restrictions did not differ between the compared areas, the lockdown may have had a greater effect on the sexual pleasure of women in urban areas.
Impaired skeletal muscle health in Parkinsonian syndromes: clinical implications, mechanisms and potential treatments
Authors: Murphy Kate T. , Lynch Gordon S. 
Published: August 2023

AbstractThere is increasing evidence that neurodegenerative disorders including the Parkinsonian syndromes are associated with impaired skeletal muscle health, manifesting as wasting and weakness. Many of the movement problems, lack of muscle strength and reduction in quality of life that are characteristic of these syndromes can be attributed to impairments in skeletal muscle health, but this concept has been grossly understudied and represents an important area of unmet clinical need. This review describes the changes in skeletal muscle health in idiopathic Parkinson's disease and in two atypical Parkinsonian syndromes, the most aggressive synucleinopathy multiple system atrophy, and the tauopathy progressive supranuclear palsy. The pathogenesis of the skeletal muscle changes is described, including the contribution of impairments to the central and peripheral nervous system and intrinsic alterations. Pharmacological interventions targeting the underlying molecular mechanisms with therapeutic potential to improve skeletal muscle health in affected patients are also discussed. Although little is known about the mechanisms underlying these conditions, current evidence implicates multiple pathways and processes, highlighting the likely need for combination therapies to protect muscle health and emphasizing the merit of personalized interventions for patients with different physical capacities at different stages of their disease. As muscle fatigue is often experienced by patients prior to diagnosis, the identification and measurement of this symptom and related biomarkers to identify early signs of disease require careful interrogation, especially for multiple system atrophy and progressive supranuclear palsy where diagnosis is often made several years after onset of symptoms and only confirmed post‐mortem. We propose a multidisciplinary approach for early diagnosis and implementation of personalized interventions to preserve muscle health and improve quality of life for patients with typical and atypical Parkinsonian syndromes.
A qualitative study of LGBTQIA+ genetic counselors' experiences while applying to graduate school
Authors: O'Sullivan Lauren , Zayhowski Kimberly , Hoffman Eileen , Carmichael Nikkola 
Published: August 2023

AbstractResearch has shown that lesbian, gay, bisexual, transgender, queer, intersex, asexual and other sexual and gender minority (LGBTQIA+) healthcare students experience discrimination during admissions and training. While several studies have examined the experiences of racial and ethnic minorities within the genetic counseling field, the admissions experiences of LGBTQIA+ individuals have not been explored. Through semi‐structured interviews, this qualitative study investigated the experiences of ten LGBTQIA+ genetic counselors and genetic counseling students during graduate school admissions. Interview questions focused on participants' perceptions of the genetic counseling field prior to applying, important factors in choosing and ranking programs, decisions surrounding disclosure of LGBTQIA+ identities, interview experiences related to their identities, and the impacts, if any, of their identities on their overall admissions journey. Transcripts were coded and analyzed utilizing a constructivist grounded theory approach, resulting in the emergence of themes regarding factors that influenced participants' decisions to disclose their identity and how their LGBTQIA+ identity factored into their selection of a training program. This study adds new perspectives to the conversations around diversity, equity, and inclusion within the genetic counseling field. Further, it provides genetic counselors and genetic counseling programs insight into inclusive admissions processes and suggests ways to improve inclusivity in graduate admissions.
The creation and climatology of a large independent rainfall event database for Great Britain
Authors: Herrera Roberto Villalobos , Blenkinsop Stephen , Guerreiro Selma B. , Fowler Hayley J. 
Published: August 2023

AbstractExtreme rainfall studies generally focus on hourly or daily rainfall accumulations. Additionally, studies focus on annual maxima (AM) or ‘peak intensities’. Although this approach is useful, the use of fixed‐duration accumulations simplifies inherently continuous rainfall processes which, at a rain gauge, are experienced as rainstorms of varying duration. A gap also exists in the study of sub‐hourly rainfall extremes which are an important source of flash floods. Here, we present the first large‐scale study of rainstorms in the United Kingdom. We leverage a recently created sub‐hourly resolution rain gauge dataset for Great Britain to identify over 70,000 rainstorms that generated AM rainfall intensities across a range of sub‐hourly to daily durations at 1279 rain gauges up to 2018. Our findings are consistent with previous studies of UK rainfall extremes and their climatology, where strong east–west differences are found in the magnitude of autumn and winter long‐duration (over 12‐h) rainstorms. We observe broad similarities in the behaviour of short (under 4‐h) rainstorms across GB, which are dominated by seasonal variations in convective activity rather than by geographical location. Our study reveals substantial overlaps between AM of different durations, with single rainstorms containing AM across a wide range of durations. We also demonstrate the substantial correlation between rainstorm duration and volume. These results challenge common independence assumptions used in the statistical modelling of rainfall extremes using extreme value theory. Our results represent an opportunity to refine rainfall design methods towards improved, robust representations of rainstorms.
The effect of resiliency and self‐regulation on immigrants’ job search behavior
Authors: McLarnon Matthew J. W. , Rothstein Mitchell G. , King Gillian A. , Medianu Stelian , Sutter Alina , Kisinger Kelly 
Published: August 2023

AbstractThis research explores the relations between resiliency and its affective, behavioral, and cognitive protective factors and self‐regulatory processes and job search behaviors among recent immigrants. The study uses data from 201 first‐generation immigrants to test whether these self‐regulatory variables incrementally predict job search self‐efficacy, satisfaction, clarity, and intensity over and above the trait‐based protective factors. By going beyond traditional protective factors, we provide a more nuanced understanding of the drivers of immigrants’ job search behaviors. Finally, this research provides an empirical foundation for the development of future training programs aimed at enhancing immigrant resiliency and improving job search outcomes.
Utility of Targeted Positron Emission Tomography Imaging to Predict Schwannoma Growth in a Murine Tumor Model
Authors: Morgan Jake , Manickavel Sudhir , Sorace Anna , Hartman Yolanda , Eli Abbigael , Massicano Adriana , Gonzalez Manuel Lora , Warram Jason M. , Walsh Erika 
Published: August 2023

ObjectiveTo identify if targeted positron emission tomography (PET) imaging with radiolabeled antibodies can predict tumor growth rate and ultimate tumor size in a murine flank schwannoma model.Study DesignAnimal research study.MethodsRat schwannoma cells were cultured and implanted into 40 athymic nude mice. Once tumors reached 5 mm in diameter, 30 mice were injected with zirconium‐89 labeled antibodies (HER2/Neu, vascular endothelial growth factor receptor 2 (VEGFR2), or IgG isotype). PET/CT was performed, and standardized uptake values (SUV) were recorded. Tumors were serially measured until mice were sacrificed per IACUC protocol. Statistical analysis was performed to measure correlations between SUV values, tumor size, and growth.ResultsMean tumor sizes in mm3 on Day 0 were 144 ± 162 for anti‐HER2/Neu, 212 ± 247 for anti‐VEGFR2, and 172 ± 204 for IgG isotype groups respectively. Mean growth rates in mm3/day were 531 ± 250 for HER2, 584 ± 188 for VEGFR2, and 416 ± 163 for the IgG isotype group. For both initial tumor size and growth rates, there was no significant difference between groups. There were significant correlations between maximum tumor volume and both the SUV max in the HER2 group (p = 0.0218, R2 = 0.5020), and we observed significant correlations between growth rate, and SUV values (p = 0.0156, R2 = 0.5394). Respectively, in the anti‐VEGFR2 group, there were no significant correlations.ConclusionIn a murine schwannoma model, immunotargeted PET imaging with anti‐HER2/Neu antibodies predicted tumor growth rate and final tumor size. Laryngoscope, 134:1372–1380, 2024
Oxidized Xanthan Gum Crosslinked NOCC: Hydrogel System and Their Biological Stability from Oxidation Levels of the Polymer
Authors: Quan Vo Minh , Do Dat‐Quoc , Luong Tin Dai , Tang Tuan‐Ngan , Vu Binh Thanh , Le Hien‐Phuong , Vo Phuc H. , Dang Nhi Ngoc‐Thao , Tran Quyen Ngoc , Trinh Nhu‐Thuy , Nguyen Thi‐Hiep 
Published: August 2023

AbstractDynamic hydrogel systems from N,O‐carboxymethyl chitosan (NOCC) are investigated in the past years, which has facilitated their widespread use in many biomedical engineering applications. However, the influence of the polymer's oxidation levels on the hydrogel biological properties is not fully investigated. In this study, chitosan is converted into NOCC and introduced to react spontaneously with oxidized xanthan gum (OXG) to form several injectable hydrogels with controlled degradability. Different oxidation levels of xanthan gum, as well as NOCC/OXG volume ratios, are trialed. The infrared spectroscopy spectra verify chemical modification on OXG and successful crosslinking. With increasing oxidation levels, more dialdehyde groups are introduced into the OXG, resulting in changes in physical properties including gelation, swelling, and self‐healing efficiency. Under different volume ratios, the hydrogel shows a stable structure and rigidity with higher mechanical properties, and a slower degradation rate. The shear‐thinning and self‐healing properties of the hydrogels are confirmed. In vitro assays with L929 cells show the biocompatibility of all formulations although the use of a high amount of OXG15 and OXG25 limited the cell proliferation capacity. Findings in this study suggested a suitable amount of OXG at different oxidation levels in NOCC hydrogel systems for tissue engineering applications.
Improving Photovoltaic Performance of All‐Polymer Solar Cells by Adding an Amorphous B←N Embedded Polymer as the Third Component
Authors: Tan Xueyan , Jian Junyang , Zheng Xueqiong , Zhao Jinying , Huang Jianhua 
Published: August 2023

AbstractCurrently, most of the disclosed ternary strategies to improve photovoltaic performance of all‐polymer solar cells (all‐PSCs) commonly focus on the guest polymers having similar structures with the host polymer donors or acceptors. Herein, this work develops a distinctive ternary method that adding an amorphous B←N embedded polymer named BN‐Cl‐2fT to a crystallized host polymer blend of PM6 (a commercialized polymer donor) and PY‐TT (a copolymer of Y6 and thieno[3,2‐b]thiophene). Although the structures between BN‐Cl‐2fT and PM6 and PY‐TT are completely different, excellent miscibility is found between BN‐Cl‐2fT and both of the host PM6 and PY‐TT, which can be interpreted by the crowded phenyl groups anchoring along the backbone of BN‐Cl‐2fT, leading to weak self‐aggregation. Glazing incidence wide‐angle X‐ray diffraction (GIWAXS) measurements explicitly confirm the crystallization of PM6 and PY‐TT and amorphous feature of BN‐Cl‐2fT. Furthermore, adding 10 wt% BN‐Cl‐2fT to PM6:PY‐TT can significantly enhance the crystallization of the host polymers. Thus the ternary devices based on PM6:PY‐TT:BN‐Cl‐2fT afford promote short‐circuit current density (JSC, 23.29 vs. 21.80 mA cm−2), fill factor (FF, 62.4% vs. 60.0%), and power conversion efficiency (PCE, 13.70% vs. 12.23%) in contrast to these parameters of binary devices based on PM6:PY‐TT. This work provides a unique and enlightening avenue to design high performance all‐PSCs by adding amorphous B←N embedded polymers as guest component to enhance host‐crystallization.
Application of the 6S management strategies
Authors: Deng Haiying , Lin Lizhen 
Published: August 2023

AbstractAimTo explore the value of the 6S management strategies in COVID‐19 wards.DesignNurses from the first Fujian medical team in aiding Hubei Province at Wuhan Jinyintan Hospital (2 February, 2020–24 March, 2020) were recruited and instructed to adopt the 6S management strategies for nursing management.MethodsThe paired‐sample t‐test was performed to compare the nursing quality, core capabilities of nurses, nursing preparation time, and nursing error rates before and after implementation.ResultsAfter implementation of the 6S management strategies, a total of 93 nurses experienced significant improvements in nursing quality, especially in workplace stress, material preparation, and medication management (p < .001). Adoption of the 6S model for nursing management in COVID‐19 wards effectively improves nursing quality, enhances the core capabilities of nurses, reduces nursing preparation time, and lowers nursing error rates.
Effect of mold on curing deformation of resin transfer molding‐made textile composites
Authors: Zhang Ce , Sun Ying , Xu Jing , Shi Xiaoping , Zhang Guoli 
Published: August 2023

AbstractIn the process of preparing textile composites by resin transfer molding (RTM) method, both the upper and lower surface of the mold will interact with the composite parts due to the mismatch of thermal expansion coefficient between the mold and the part, resulting in warpage deformation. To address this key technical problem, this article first studied the effect of mold on the warpage deformation of composite material under different fiber volume fractions. Then a mold–part interaction modeling method for RTM process with nonthermoelastic deformation is proposed. By introducing shear layers between the upper and lower surfaces of the mold and the composite part, a finite element simulation model for predicting the curing deformation of the component is established and experimentally verified. The results show that the effect of mold–part interaction on the warpage deformation of the composite decreases with increasing fiber volume fraction. Meanwhile, the proposed modeling method can avoid complete material characterization, and the comparison between experimental and simulation results proves that the model can accurately simulate the curing deformation of composite components under the same process conditions. Finally, the analysis reveals that the interaction caused by thermal mismatch between the composites and the mold is less related to the intermediate layup, but mainly related to the fiber orientation of the layup layer in contact with the mold.Highlights
The warpage deformation law of the mold on the composites with different fiber volume fractions is investigated.
A mold–part interaction modeling method for a resin transfer molding process with nonthermoelastic deformation is proposed, where the mold stretching effect is represented by the cumulative effect of the interaction between the two layers on the upper and lower surfaces of the part.
Preparation and characterization of silk hybridizing carbon fiber/polybutylene succinate composite
Authors: Zou Ting , Ji Ruyi , Li Yuanyuan , Zhang Yan , Wang Ping 
Published: August 2023

AbstractCarbon fiber‐reinforced composites (CFRPs) offer numerous benefits due to their exceptional strength and modulus, making them extensively utilized in various applications. However, the disadvantage of poor impact resistance also limits their application in some aspects. In this study, silk fabric is used to hybridize CFRPs, and the silk/carbon fiber‐reinforced polybutylene succinate (PBS) composites were fabricated by combining the film stacking technique with the hot‐pressing method. The mechanical, thermal, and thermodynamic properties of the composites were assessed using various techniques, including tensile testing, scanning electron microscope, flexural testing, Charpy impact test, low‐velocity impact test, differential scanning calorimetry, and dynamic mechanical thermal analysis, and the optimal preparation process conditions (140°C/15 min) for the composites were obtained. Additionally, the mechanical properties of silk fiber/PBS, carbon fiber/PBS, and hybrid composite materials are comprehensively compared and evaluated. This work indicates that the synergistic toughening of silk and PBS significantly improves the impact resistance of CFRPs, and the impact strength of sample 5 (140°C/15 min) (54.97 kJ/m2) is higher than many reported values for CFRPs.Highlights
High strength, high modulus carbon fiber, and high toughness silk were rarely combined as reinforcing phases for PBS composites.
A hybrid composite material with a balanced combination of stiffness, strength, and toughness was prepared.
Compared with similar studies, it was found that the hybrid composite prepared by this work exhibited relatively balanced mechanical properties, especially, its impact strength higher than many reported values.