bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of New-onset Stroke in Patients with Type 2 Diabetes with Chronic Kidney Disease on Sodium-glucose Co-transporter-2 Inhibitor Users
Authors: Jong Gwo-Ping , Lin Tsung-Kun , Liao Pei-Lun , Huang Jing-Yang , Yang Tsung-Yuan , Pan Lung-Fa 
Published: February 2023

Abstract
Clinical studies have investigated the effects of using sodium-glucose co-transporter-2 (SGLT2) inhibitors on the development of new-onset stroke (NOS) in patients with type 2 diabetes (T2D) and chronic kidney disease (CKD), but the findings are inconsistent. This study aimed to examine the association between the use of SGLT2 inhibitors and NOS risk in patients with T2D and CKD. We conducted a nationwide retrospective cohort study using data from the Taiwan Health Insurance Review and Assessment Service database for the years 2004 to 2019. The primary outcome was the risk of incident stroke, which was estimated using hazard ratios (HRs) and 95% confidence intervals (CIs). We used multiple Cox regression modeling to analyze the association between SGLT2 inhibitor use and the risk of stroke in patients with T2D and CKD. In a cohort of 113,710 patients with T2D and CKD who were using SGLT2 inhibitors and 227,420 patients with T2D and CKD who were not using SGLT2 inhibitors, after applying a 1:2 sex- and age-matching strategy, 2,842 and 7,169 NOS events were recorded, respectively. The event rate per 10,000 person-months was 10.60 (95% CI 10.21 to 11.03) for SGLT2 inhibitor users and 13.71 (13.39–14.03) for non-SGLT2 inhibitor users. After adjusting for the index year, sex, age, comorbidities, and concurrent medication, there was a decreased risk of NOS for SGLT2 inhibitor users (adjusted HR 0.80; 95% CI 0.77–0.84) compared with non-SGLT2 inhibitor users. The sensitivity test for the propensity score 1:1-matched analyses showed similar results (adjusted HR 0.80; 95% CI 0.76–0.84). The type of SGLT2 inhibitor subgroup analysis for incident stroke showed consistent results. We concluded that the use of SGLT2 inhibitors in patients with T2D and CKD decreased the risk of NOS. The decreased risk of NOS in patients with T2D and CKD was greater among female and less than 50 years patients.
TRIM72 inhibits cell migration and epithelial-mesenchymal transition by attenuating FAK/Akt signalling in colorectal cancer
Authors: Faleti Oluwasijibomi Damola , Tan Haiqi , Gong Yibing , Huang Jing , Deng Simin , Qiu Lizhen , Yao Jinke , Wu Gongfa , Lyu Xiaoming 
Published: February 2023

Abstract
TRIM72 (MG53) is a membrane repair protein with E3-ligase activity. In this study, we investigated its clinical significance and biological function in colorectal cancer (CRC). Reverse transcription-PCR was used to identify TRIM72 expression in primary CRC tumour tissue and the paired liver metastasis tumor samples. Results indicated that TRIM72 expression in paired liver metastases tissue was lower compared to the primary colon cancer tumour (p < 0.001). Aberrant expression of TRIM72 was significantly associated with the regional lymph node metastasis and clinical stage. Consistent with this, TRIM72 overexpression inhibited migration, intravasation and epithelial-mesenchymal transition of CRC cells in vitro and in vivo. In contrast, we found that TRIM72 knockdown significantly increased CRC cells' migration and invasion. Notably, we revealed that TRIM72 interacts with FAK and attenuate colon cancer metastasis by regulating FAK/Akt signalling pathway. Furthermore, patients with low expression of TRIM72 had poorer survival in two independent datasets. These findings indicate that TRIM72 plays a vital role in the metastasis of human colon cancer and possesses the potential to predict the survival of patients.
Seamguard Buttressing (SGB) and Oversewing/Suturing (OS/S) of the Staple Line in Sleeve Gastrectomy Appear to be Associated with Comparable Postoperative Outcomes. A Meta-Analysis of 11 Studies Comparing Two Effective Reinforcement Methods.
Authors: Diab Abdul-Rahman Fadi , Malaussena Zachary , Ahmed Abrahim , West William , Docimo Salvatore , Sujka Joseph Adam , DuCoin Christopher Garnet 
Published: February 2023

AbstractPostoperative staple line hemorrhage and leakage are major causes of postoperative morbidity after laparoscopic sleeve gastrectomy (LSG). Many staple line reinforcement (SLR) techniques have been innovated in efforts to reduce such complications; these include oversewing/suturing (OS/S), omentopexy/gastropexy (OP/GP), gluing, and buttressing. Therefore, surgeons are often confused of which SLR they should use. Recent high-quality evidence shows that Seamguard buttressing (SGB) and OS/S are associated with better postoperative outcomes when each is compared to no SLR; having said that, it is unknown if one of these 2 methods is superior to the other. The aim of this study is to compare postoperative outcomes between LSG with SGB versus LSG with OS/S. Key points • No significant difference in postoperative bleeding, postoperative leakage, and readmission was observed between SGB and OS/S. • SGB was associated with decreased incidence of reoperations, and without significant heterogeneity which makes the decrease generalizable. However, when compared to OS/S, number need to treat (NNT) with SGB to prevent a case reoperation is 166. • OS/S was associated with shorter LOS, but this isn’t generalizable because of significant heterogeneity.
Compact, broadband, and efficient LP01 -LP11a mode converter based on cascaded asymmetric Y-junction
Authors: Zhang Hao , Deng Jia Yao , Wang Meng Ke , Ma Xiao Xia , Chen Kai Xin 
Published: February 2023

Abstract

In this paper, a compact and broadband mode converter, which can achieve efficient LP01-LP11a mode conversion, is demonstrated with cascaded asymmetric Y-junction in polymer waveguide. Our typical fabricated converter has a compact footprint of 1.5 mm × 14 µm and shows a mode conversion efficiency larger than ~ 98%, a crosstalk less than ~ −17.5 dB, and an insertion loss lower than ~ 5.8 dB for both x and y polarizations over the C + L band. Our proposed mode converter could find applications in broadband mode-division multiplexing transmission systems.
Consistent epistemic planning without communication for MADRL
Authors: Wu Peiliang , Luo ShiCheng , Tian LiQiang , Mao BingYi , Chen enbai 
Published: February 2023

Abstract
Multi-agent cooperation needs to reason about beliefs in the partially observable environment without communication, but the traditional Multi-agent Deep Reinforcement Learning (MADRL) algorithm struggles to handle the uncertainty of agents. Multi-agent Epistemic planning (MEP) tries to let the agent find a best plan to complete the cooperation task, so as to more effectively solve the uncertainty. However, inconsistent planning arises if the MADRL only adds MEP. We propose a MADRL-based policy network architecture called SMM-MEPP: Shared Mental Model - Multi-agent Epistemic Planning Policy. Firstly, Multi-agent Epistemic Planning and MADRL are investigated to build the "Perception-Planning-Action" multi-agent epistemic planning framework. Then, mental model in psychology is introduced and descript as a neural network. Thirdly, parameter sharing mechanism is utilized to achieve the shared mental model and maintain the consistency of epistemic planning. Finally, we apply the SMM-MEPP architecture to three advanced MADRL algorithms (i.e., MAAC, MADDPG and MAPPO) and conduct comparative experiments in multi-agent cooperation tasks. Experiments show that the proposed method can bring consistent planning for multiple agents, and improves convergence speed or training effect in partially observable environment without communication.
Effect of clay-pot irrigation on Citrullus colocynthis plant growth for arid land restoration (A case study: southeast of Iran)
Authors: Jahantigh Moien , Jahantigh Mansour 
Published: February 2023

Abstract

This study aimed to investigate growth performance of Citrullus colocynthis plant under clay-pot irrigation to restore vegetation in abandoned farmlands of arid regions. So, in this research, the influence of clay-pot and traditional irrigation methods experimented on some growth parameters of Citrullus colocynthis plant from 2019 to 2021.The experiment had been conducted in a randomized complete block design with 5 replications. In each treatment, plant growth characteristics such as shrub length, number of seeds per fruit, number of fruits per plant, number of branches per plant, dry weight of fruit, and fruit yield were measured. The results indicate that the effect of different irrigation methods on growth characteristics under the influence of irrigation methods was significantly different (p ≤ 0.05). Also finding indicate that the amounts of water consumption were significantly different at the level of five percentage (P < 0.05) and the most appropriate irrigation method by significant increase of WUE is related to clay-pot irrigation. Based on the results of the research, the growth performance of Citrullus colocynthis plant during the second and third growing seasons significantly increased which non-irrigation conditions. Following the results, the period of growth of Citrullus Colocynthis is synchronous with the critical month (April, June, July, and September respectively) when the value of wind speed, temperature, and evaporation rate reaches its value maximum. According to the results, the implementation of clay-pot irrigation methods for the establishment of Citrullus colocynthis plant with high adaptability is a practical option to restore vegetation in abandoned farmlands of the study area.
Provision of outdoor nature-based activity for older people with cognitive impairment: protocol for a scoping review from the ENLIVEN project
Authors: Collins Rachel , Owen Steve , Opdebeeck Carol , Ledingham Katie , Connell Joanne , Quinn Catherine , Page Stephen , Clare Linda 
Published: February 2023

Abstract

The aims of the scoping review for which the protocol is presented here are:
· To identify and characterise the types of outdoor nature-based activity for older people with dementia and other forms of cognitive impairment that have been the subject of research and for which research evidence is available.
· To identify and describe the range of outcomes examined in the research studies on this topic.
A Retrospective Comparison of 90-day Outcomes, Length of Stay, &amp; Readmissions Between Robotic-Assisted &amp; Laparoscopic Colectomy
Authors: Pervaiz Sahir S. , D'Adamo Christopher , Mavanur Arun , Wolf Joshua H. 
Published: February 2023

Abstract
Purpose: Investigations generally assess 30-day perioperative outcomes with robotic-assisted and laparoscopic colectomy. Outcomes beyond 30-days serve as a quality metric of surgical services and an assessment of 90-day outcomes may have greater clinical utility. The purpose of this study was to assess 90-day outcomes, length of stay (LOS), and readmissions among patients who underwent a robotic-assisted versus laparoscopic colectomy using a national database.
Methods: Patients undergoing either robotic-assisted or laparoscopic colectomy were identified using Current Procedural Terminology (CPT) codes within PearlDiver, a national, inpatient records database from 2010-2019. Outcomes were defined using the National Surgical Quality Improvement Program (NSQIP) risk calculator and identified using International Classification of Disease (ICD) diagnosis codes. Categorical variables were compared using chi-square tests and continuous variables were compared using paired t-tests. Covariate-adjusted regression models were also constructed to evaluate these associations while accounting for potential confounders.
Results: A total of 82,495 patients were assessed in this study. At 90-days, patients of the laparoscopic colectomy cohort experienced a higher rate of complications than patients who underwent robotic-assisted colectomy (9.5% vs. 6.6%, p<0.001). There were no significant differences in LOS (6 days vs. 6.5 days, p=0.08) and readmissions (6.1% vs. 6.7%, p=0.851) at 90-days.
Conclusion: Patients undergoing robotic-assisted colectomy have a lower risk for morbidity at 90-days. Neither approach is superior for LOS or 90-day readmissions. Both techniques are effective minimally invasive procedures, yet patients may gain a greater risk benefit from robotic colectomy.
AntiCoV-DB: A novel database resource of Anti COVID- 19, Anti CoronaVirus, Natural products and peptides
Authors: zouhir Abdelmajid , Khamessi Oussema , Kamoun Selim , Hkimi Chaima , Othman Houcemeddine , Cherif Ammar , Mahjoubi Basma , Jr Taoufik , Sebei Khaled , Ghedira Kais 
Published: February 2023

Abstract

SARS-CoV-2 is one of the most common pathogens. SARS-CoV-2 has shown 80% genome identity with other Corona viruses. Due to the high rate of infection reported in the COVID-19 pandemic, in recent months, a lot of studies have been performed on the introduction of antiviral drugs. Secondary metabolites as alkaloids, essential oils, flavonoids, polyphenols and other natural compounds have shown promise as antiviral agents against several pathogenic viruses including SARS-CoV-2. The antimicrobial peptides display narrow-or broad spectrum activity against microbes including COVID-19 causative agent. The gathering of such data related to these molecules in one central database resource would therefore be of great benefit to the exploitation of these anti-coronavirus peptides and anti-COVID-19 secondary metabolites in the present context of increasing contagiousness in humans and its spread across the globe. The database AntiCov-DB has been developed to facilitate access to important information on 294 secondary metabolites with 90 alkaloids, 18 essential oils, 88 flavonoids, 15 polyphenols, 93 other natural compounds, 34 peptides anti-COVID-19 and 104 antimicrobial sequences of peptides reported to act as anti-CoronaVirus. The database permits a quick and easy search on the one hand of secondary metabolites based on their target molecules of COVID-19 and general data and on the other hand of antiviral peptides based on their activity as well as their general, physicochemical properties and literature. AntiCoV-DB is hosted on the web server at the Institut Pasteur de Tunis, Tunisia (IPT) and is freely available through this link: http://tesla.pasteur.tn/DBs/AntiCoV_DB/index.php
Mechanism of Saffron Extract against Cardiotoxicity Induced by Doxorubicin: 4D Label-Free Quantitative proteomics Analysis and Bioinformatic Study
Authors: Sa Rina , Lin Zhijian , Huang Jinjian , Wang Yu , Lv Jintao , Zhang Xiaomeng , Pan Xinbo , Huang Jianmei , Zhang Bing 
Published: February 2023

Abstract

Anthracycline induced cardiotoxicity, represented by Doxorubicin (DOX), is the main side effect limiting the use of anthracyclines as effective chemotherapeutic agents. These mechanisms have not been fully elucidated. It is necessary to refine the mechanisms of DOX cardiotoxicity and to develop drugs that can counteract DOX cardiotoxicity. In previous studies, the saffron extract was reported to successfully relieve DOX cardiotoxicity, but the mechanisms are unclear. First, we quantified 3423 proteins in the hearts of DOX group rats vs. control group rats using proteomics with high-sensitivity mass spectrometry to identify key proteins and signaling pathways. Furthermore, the important role of ribosomal proteins in the mechanism of DOX cardiotoxicity was revealed by the GEO transcriptome dataset and the literature on ribosomal protein ubiquitination. Second, we analyzed the key mechanisms and targets of saffron against DOX cardiotoxicity via 4D label-free proteomics. Through validation by ELISA, we identified the proteins XIRP2, EPHX1, SORBS2, CD81, FLOT2, FLOT1, CD59, DCN, CTSD and HSPA5 as critical targets of saffron extract against DOX cardiotoxicity. These discoveries have contributed to a deeper understanding of the mechanisms of DOX cardiotoxicity, as well as to the identification of the key therapeutic targets of saffron for preventing DOX cardiotoxicity.
Hypothermic Oxygenated Machine Perfusion Attenuates Peri-Perfusional Inflammatory Mediator Release and Preserves Cholangiocyte Structure and Function Early After Liver Transplant
Authors: Panayotova Guergana G. , Qin Yong , Bonder Edward M. , Mucahit Huri U. , Simonishvili Sopio , Ayee Brian G. , Davis Justin L. , Galan Mark A. , Paterno Flavio , Lee-Riddle Grace S. , Amin Arpit , Lunsford Keri E. , Guarrera James V. 
Published: February 2023

Abstract
Background
Hypothermic Oxygenated Machine Perfusion (HMP-O2) is a dynamic preservation technique which improves ischemia/reperfusion injury (IRI) of liver grafts vs. static cold storage (SCS). The exact molecular pathways affected, particularly in the setting of biliary injury, remain undefined. Here we investigate the peri-perfusional and tissue mediators of liver preservation injury and cholangiocyte dysfunction early after liver transplant.
Methods
Patients were transplanted at a single center as part of the multi-center randomized controlled PILOT trial (NCT03484455). Livers were randomized to perfusion via the LifePort Liver Transporter (HMP-O2, Organ Recover Systems, Itasca, IL) or to SCS. Clinical complications were assessed utilizing the Comprehensive Complication Index (CCI). Corresponding biospecimen analysis of preservation fluid (effluent, prior to liver implantation), bile, and bile duct tissue (both 1hr post-reperfusion) was performed. Effluent biochemistry was assessed via Luminex, and bile biochemistry was assessed via iSTAT-1/CG8+. Tissue injury was identified via histology and immunohistochemistry (IHC). p < 0.05 was considered significant.
Results
Liver transplant was performed in 20 patients (7 HMP-O2; 13 SCS). Early allograft dysfunction (EAD) occurred in three cases, all SCS. HMP-O2 resulted in fewer immediate post-operative complications (CCI 42 vs 56, p < 0.05) and fewer biliary complications (14% vs 23%). Following HMP-O2, multiplex analysis of effluent showed decreased release of MIP-1ß (p < 0.05), IL-8, IL-6, and TNFα; bile fluid biochemistry revealed significantly preserved cholangiocyte resorptive function; and IHC analysis of bile ducts demonstrated attenuated activation of inflammatory signaling (decreased total and activated NF-κB, p < 0.0001).
Conclusions
HMP-O2 provides excellent preservation for liver allografts. Pre-implant machine perfusion appears to decrease inflammatory signaling, preserve cholangiocyte function, and protect cellular function, and may therefore confer protection from transplant related IRI.
Characteristics of Delirium and Its Association with Sedation and In-Hospital Mortality in COVID-19 Patients on Veno-venous Extracorporeal Membrane Oxygenation
Authors: Sun Philip Y , Fanning Jonathon , Peeler Anna , Shou Benjamin , Lindsley John , Caturegli Giorgio , Whitman Glenn , Cha Stephanie , Kim Bo Soo , Cho Sung-Min 
Published: February 2023

Abstract
Background

Veno-venous extracorporeal membrane oxygenation (VV-ECMO) has been used in patients with COVID-19 acute respiratory distress syndrome (ARDS). We aim to assess the characteristics of delirium and describe its association with sedation and in-hospital mortality.

Methods

We retrospectively reviewed adult patients on VV-ECMO for severe COVID-19 ARDS in the Johns Hopkins Hospital ECMO registry in 2020-2021. Delirium was assessed by the Confusion Assessment Method for the ICU when patients scored -3 or above on Richmond Agitation-Sedation Scale (RASS). Primary outcomes were delirium prevalence while on VV-ECMO and categorization of VV-ECMO days based on delirium status.

Results

Of 47 patients (median age=51) with 6 in a persistent coma, 40 of the remaining 41 patients (98%) had ICU delirium. Delirium in the survivors (n=21) and non-survivors (n=26) was first detected at a similar time point (day 9.5[5, 14] vs. 8.5[5, 21], p=0.56) with similar total delirium days (9.5[3.3, 16.8] vs. 9.0[4.3, 28.3], p=0.43), but the RASS scores on VV-ECMO were numerically lower in non-survivors (-3.72[-4.42, -2.96] vs. -3.10[-3.91, -2.21], p=0.06). Non-survivors had significantly prolonged median delirium days (27.3[17.4, 46.4] vs. 17.0[9.9, 28], p=0.04), delirium-unassessable days on VV-ECMO with a RASS of -4/-5 (23.0[16.3, 38.3] vs. 17.0[6, 23], p=0.03), and total VV-ECMO days (44.5[20.5, 74.3] vs. 27.0[21, 38], p=0.04). The proportion of delirium-present days correlated with RASS (r=0.64, p<0.001), proportion of days with a neuromuscular blocker (r=-0.59, p=0.001) and delirium-unassessable exams (r=-0.69, p<0.001), but not with overall ECMO duration (r=0.01, p=0.96). Average daily dosage of delirium-related medications on ECMO days did not differ significantly between survivors and non-survivors. On multivariable logistic regression, proportion of delirium days was not associated with mortality.

Conclusions

Longer duration of delirium was associated with lighter analgosedation and shorter paralysis, but the condition did not discern in-hospital mortality. Future studies should evaluate analgosedation and paralytic strategies to optimize delirium, sedation level, and outcomes.
Bio-based activated carbon from husk- and wood-based biomass: comparison of carbon activation methods on organic pollutants removal
Authors: Tomin Oleksii , Yazdani Maryam Roza 
Published: February 2023

Abstract
This study aimed to investigate the effect of different activations on the properties of bio-based activated carbons (BACs) for water treatment. BACs were produced via pyrolysis by the carbonization stage and were followed by four different activation procedures. Chemical activation included the introduction of metal oxides or alkali on the structure of the sawdust-derived BACs, resulting in iron-activated carbon (BAC-Fe), copper-activated carbon (BAC-Cu), and sodium-activated carbon (BAC-Na). The physical activation was conducted in a CO2 environment with the usage of two types of locally available biomasses, resulting in husk-activated carbon (HAC) and wood-activated carbon (WAC). Depending on the activation, BACs can be developed with high porosity, active sites, and different additional functionalities such as antimicrobial and magnetic. The adsorption of natural organic matter (NOM) with chemically activated BACs yielded high removal percentages (97, 87, and 80% for BAC-Fe, BAC-Cu, and BAC-Na, respectively). The physically activated BACs demonstrated high adsorption capacities for dye – 278 mg/g for WAC and 213 mg/g for HAC. This outlines a wide range of BAC production possibilities with advanced functionalities.
Study of GIS-based groundwater potential zones for agricultural sustainability in the arid region
Authors: Memon Aneela Hameem , Soomro Abdul Ghani , Panhwar Sallahuddin , Ahmed Keerio Hareef , Khokhar Naddar Hussain , Bajkani Jumo Khan , Siddiqui Sabeen , Gadehi Mumtaz Ali 
Published: February 2023

Abstract
The cluster-wise area of shallow and deep aquifer zones is used to estimate the potential of groundwater. The potential of the shallow aquifer zone is estimated at 4.61 MCM (million cubic meters) and for the deep aquifer zone at 17,509.03 MCM, while the total groundwater potential for both aquifer zones is estimated at 17,513.64 MCM. The Geographical Information System (GIS) was employed efficiently to estimate the subsurface volume of the lithological rock layers using cost-effective and time-saving techniques, while the Rockwork software integrated with GIS was successfully used to visualize the subsurface lithology and stratigraphy of the aquifer zones. The estimated potential of groundwater can be uncovered by using the alternative solar pumping system to improve the agricultural system in the study area, thereby reducing the migration rate, reducing poverty, and improving the socio-economic conditions of livelihood. In the future, too, it will be essential to design water quality studies to ensure the proper use of groundwater.