bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can AI chatbots help retain customers? Impact of AI service quality on customer loyalty
Authors: Chen Qian , Lu Yaobin , Gong Yeming , Xiong Jie 
Published: January 2023

PurposeThis study investigates whether and how the service quality of artificial intelligence (AI) chatbots affects customer loyalty to an organization.Design/methodology/approachBased on the sequential chain model of service quality loyalty, this study first classifies AI chatbot service quality into nine attributes and then develops a research model to explore the internal mechanism of how AI chatbot service quality affects customer loyalty. The analysis of survey data from 459 respondents provided insights into the interrelationships among AI chatbot service quality attributes, perceived value, cognitive and affective trust, satisfaction and customer loyalty.FindingsThe results show that AI chatbot service quality positively affects customer loyalty through perceived value, cognitive trust, affective trust and satisfaction.Originality/valueThis study captures the attributes of the service quality of AI chatbots and reveals the significant influence of service quality on customer loyalty. This study develops research on service quality in the information system (IS) field and extends the sequential chain model of quality loyalty to the context of AI services. The findings not only help an organization find a way to improve customers' perceived value, trust, satisfaction and loyalty but also provide guidance in the development, adoption, and post-adoption stages of AI chatbots.
Ethics‐Related Mentoring: A Scale Development and Test of its Role in Promoting Protégé Ethical Behaviour
Authors: Busch Corinna , Crawshaw Jonathan , Guillaume Yves , Legood Alison 
Published: January 2023

AbstractOur research examines the importance of ethics‐related mentoring, its measurement and potential role in promoting protégé ethical behaviours. In Study 1, 25 interviews with mentoring experts generated 40 items for a new measure of ethics‐related mentoring. Across studies 2 and 3, exploratory and confirmatory factor analysis, using data collected from 114 and 152 protégés, respectively, reduced these to 15 items and supported its confirmatory and discriminant validity. Study 4, a scenario‐based experiment, confirmed that protégé perceptions of their ethics‐related mentoring increases their organizational citizenship behaviour (OCB) whilst reducing their counterproductive work behaviour (CWB). Drawing on social learning theory and moral identity theory, we demonstrate that both moral identity and moral self‐efficacy mediate the relationship with CWB, but only moral identity mediates the relationship with OCB. We found limited support for a moderating role of mentor prototypicality. Overall, we present strong evidence for the reliability and validity of our new ethics‐related mentoring measure and a new theoretical framework explaining its potential role in promoting protégé ethical behaviours.
Mitochondrial stress and mitokines in aging
Authors: Burtscher Johannes , Soltany Afsaneh , Visavadiya Nishant P. , Burtscher Martin , Millet Grégoire P. , Khoramipour Kayvan , Khamoui Andy V. 
Published: January 2023

AbstractMitokines are signaling molecules that enable communication of local mitochondrial stress to other mitochondria in distant cells and tissues. Among those molecules are FGF21, GDF15 (both expressed in the nucleus) and several mitochondrial‐derived peptides, including humanin. Their responsiveness to mitochondrial stress induces mitokine‐signaling in response for example to exercise, following mitochondrial challenges in skeletal muscle. Such signaling is emerging as an important mediator of exercise‐derived and dietary strategy‐related molecular and systemic health benefits, including healthy aging. A compensatory increase in mitokine synthesis and secretion could preserve mitochondrial function and overall cellular vitality. Conversely, resistance against mitokine actions may also develop. Alterations of mitokine‐levels, and therefore of mitokine‐related inter‐tissue cross talk, are associated with general aging processes and could influence the development of age‐related chronic metabolic, cardiovascular and neurological diseases; whether these changes contribute to aging or represent “rescue factors” remains to be conclusively shown. The aim of the present review is to summarize the expanding knowledge on mitokines, the potential to modulate them by lifestyle and their involvement in aging and age‐related diseases. We highlight the importance of well‐balanced mitokine‐levels, the preventive and therapeutic properties of maintaining mitokine homeostasis and sensitivity of mitokine signaling but also the risks arising from the dysregulation of mitokines. While reduced mitokine levels may impair inter‐organ crosstalk, also excessive mitokine concentrations can have deleterious consequences and are associated with conditions such as cancer and heart failure. Preservation of healthy mitokine signaling levels can be achieved by regular exercise and is associated with an increased lifespan.
Financial Inclusion or Subordination? The Monetary Politics of Debt in Cambodia
Authors: Green W. Nathan 
Published: January 2023

AbstractFinancial inclusion is a leading driver of household debt across the global South. Although critical geographers have analysed this debt through the lens of financialisation, few have examined it in terms of monetary politics. This is a salient issue, because poorer nations often have limited control over their monetary policy due to their dependence on foreign currencies, which can adversely affect the structure of their financial markets. Building on the concept of monetary dependency from scholarship on financial subordination, I analyse the monetary politics of debt in Cambodia. Drawing on elite interviews and ethnographic research, I argue that Cambodia's extreme monetary dependence on the US dollar has shaped monetary and fiscal policies that compel poorer households to take on private debt to pay for their basic needs. This paper advances critical geographies of debt and development by studying financial subordination and its impact on financial inclusion in the global South.
Efficacy of 1‐kestose supplementation in patients with mild to moderate ulcerative colitis: A randomised, double‐blind, placebo‐controlled pilot study
Authors: Ikegami Shuji , Nakamura Masanao , Honda Takashi , Yamamura Takeshi , Maeda Keiko , Sawada Tsunaki , Ishikawa Eri , Yamamoto Kenta , Furune Satoshi , Ishikawa Takuya , Furukawa Kazuhiro , Ohno Eizaburo , Ishigami Masatoshi , Kinoshita Fumie , Kadota Yoshihiro , Tochio Takumi , Shimomura Yoshiharu , Hirooka Yoshiki , Kawashima Hiroki 
Published: January 2023

SummaryBackgroundUlcerative colitis involves an excessive immune response to intestinal bacteria. Whether administering prebiotic 1‐kestose is effective for active ulcerative colitis remains controversial.AimsThis randomised, double‐blind, placebo‐controlled pilot trial investigated the efficacy of 1‐kestose against active ulcerative colitis.MethodsForty patients with mild to moderate active ulcerative colitis were randomly treated with 1‐kestose (N = 20) or placebo (maltose, N = 20) orally for 8 weeks in addition to the standard treatment. The Lichtiger clinical activity index and Ulcerative Colitis Endoscopic Index of Severity were determined. Faecal samples were analysed to evaluate the gut microbiome and metabolites.ResultsThe clinical activity index at week 8 was significantly lower in the 1‐kestose group than in the placebo group (3.8 ± 2.7 vs. 5.6 ± 2.1, p = 0.026). Clinical remission and response rates were higher in the 1‐kestose group than in the placebo group (remission: 55% vs. 20%, p = 0.048; response: 60% vs. 25%, p = 0.054). The Ulcerative Colitis Endoscopic Index of Severity at week 8 was not significantly different (2.8 ± 1.6 vs. 3.5 ± 1.6, p = 0.145). Faecal analysis showed significantly reduced alpha‐diversity in the 1‐kestose group, with a decreased relative abundance of several bacteria, including Ruminococcus gnavus group. The short‐chain fatty acid levels were not significantly different between the groups. The incidence of adverse events was comparable between the groups.DiscussionOral 1‐kestose is well tolerated and provides clinical improvement for patients with mild to moderate ulcerative colitis through modulation of the gut microbiome.
Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis: A Mendelian randomization study
Authors: Chen Jie , Ruan Xixian , Yuan Shuai , Deng Minzi , Zhang Han , Sun Jing , Yu Lili , Satsangi Jack , Larsson Susanna C. , Therdoratou Evropi , Wang Xiaoyan , Li Xue 
Published: January 2023

SummaryBackgroundEvidence for antioxidants, minerals and vitamins in relation to the risk of Crohn's disease (CD) and ulcerative colitis (UC) is limited and inconsistent. This mendelian randomization (MR) study aimed to examine the causal associations of circulating levels of antioxidants, minerals and vitamins with CD and UC.MethodsSingle‐nucleotide polymorphisms associated with antioxidants (beta‐carotene, lycopene and uric acid), minerals (copper, calcium, iron, magnesium, phosphorus, zinc and selenium), and vitamins (folate, vitamins A, B6, B12, C, D, E and K1) were employed as instrumental variables. Genetic associations with CD and UC were extracted from the UK Biobank, the FinnGen study and the International Inflammatory Bowel Disease Genetics Consortium. The inverse variance weighted method and sensitivity analyses were performed.ResultsGenetically predicted higher lycopene (OR = 0.94, 95% CI: 0.91–0.97), vitamins D (OR = 0.65, 95% CI: 0.54–0.79) and K1 (OR = 0.93, 95% CI: 0.90–0.97) levels were inversely associated with CD risk, whereas genetically predicted higher magnesium (OR = 1.53, 95% CI: 1.23–1.90) levels were positively associated with CD risk. Higher levels of genetically predicted lycopene (OR = 0.91, 95% CI: 0.88–0.95), phosphorus (OR = 0.69, 95% CI: 0.58–0.82), selenium (OR = 0.91, 95% CI: 0.85–0.97), zinc (OR = 0.91, 95% CI: 0.89–0.94), folate (OR = 0.71, 95% CI: 0.56–0.92) and vitamin E (OR = 0.78, 95% CI: 0.69–0.88) were associated with reduced UC risk, whereas genetically predicted high levels of calcium (OR = 1.46, 95% CI: 1.22–1.76) and magnesium (OR = 1.24, 95% CI: 1.03–1.49) were associated with increased risk of UC.ConclusionsOur study provided evidence that circulating levels of antioxidants, minerals and vitamins might be causally linked to the development of IBD.
Correcting for transitory effects in RCTs: Evidence from the RAND Health Insurance Experiment
Authors: Balesh Abadi Mona , Devereux Kevin , Omran Farah 
Published: January 2023

AbstractTemporary randomized controlled trials are susceptible to transitory effects that would not result from a permanent treatment. We find a large and statistically significant “deadline effect”—a surge in spending in the final treatment year—in the RAND Health Insurance Experiment, identified by random allocation to three‐ or five‐year enrolment terms. Participants facing lower coinsurance rates show larger spending surges. Partialing out the price–deadline interaction reduces in magnitude estimates of the permanent price elasticity of drug spending (and in some specifications of outpatient and supplies spending). This implies higher optimal coinsurance rates and illustrates the importance of experimental design to identifying parameters of interest in randomized controlled trials.
Digital Ethnic Enclaves: Mate Preferences and Platform Choices Among Chinese Immigrant Online Daters in Vancouver
Authors: Cai Manlin , Qian Yue 
Published: January 2023

AbstractIn light of the growing racialized immigrant population in Canada and advances in dating technologies, this study examines Chinese immigrants’ partner preferences and mate selection processes through the lens of online dating. We draw on in‐depth interviews with 31 Chinese immigrants who have used online dating services in Metro Vancouver to search for different‐sex partners. Chinese immigrant online daters show strong preferences for dating Chinese. They emphasize permanent residency status and similarity in age at arrival when evaluating potential partners. Given their preferences, Chinese immigrants strategically choose the dating platforms they primarily use. Men exhibit higher selectivity in their preferences and choices of platforms. Notably, platforms catering to Chinese users create “digital ethnic enclaves” where Chinese immigrant daters congregate. The findings illuminate the intersection of race, gender, immigrant status, and age at arrival in shaping divergent experiences of mate selection and immigrant assimilation in the digital era.
DNA damage‐induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation
Authors: Oda Tsukasa , Gotoh Nanami , Kasamatsu Tetsuhiro , Handa Hiroshi , Saitoh Takayuki , Sasaki Nobuo 
Published: January 2023

AbstractCellular senescence is linked to a wide range of age‐related diseases and can be triggered by a variety of stresses, including DNA damage. A variety of genotoxic stressors, such as anti‐cancer drugs, cause DNA double‐strand breaks (DSBs), which trigger the accumulation of the tumour suppressor protein p53 in the nucleus. Cellular stresses stabilize and activate the p53 signalling pathway, which regulates various cellular processes, such as apoptosis, DNA repair, and senescence. Although p53 signalling is a well‐known tumour suppressor pathway, it remains unclear how it is regulated during cellular senescence. Here, we show that p53‐binding protein 1 (53BP1) accumulation in the nuclear foci is required for DNA damage‐induced cellular senescence via p53 activation. In human immortalized fibroblast, shRNA‐mediated 53BP1 depletion decreased not only the expression of p53‐target genes but also the cellular senescence induced by adriamycin treatment. Furthermore, we confirmed that DSBs trigger the hyperaccumulation of 53BP1 in the nuclear foci, which plays a key role in the regulation of cellular senescence. To prevent the accumulation of 53BP1 in the nuclear foci, we used phase separation inhibitors, and siRNA against RNF168, which accumulates at DSB loci and forms complexes with 53BP1. This blocks the formation of 53BP1 nuclear foci and DNA damage‐induced cellular senescence by activating the p53 signaling pathway. In conclusion, we demonstrated that increased accumulation of 53BP1 in the nuclear foci following DNA damage activates p53 and governs cellular senescence via a liquid–liquid phase separation mechanism.
Non‐SMC condensin I complex subunit H participates in anti‐programmed cell death‐1 resistance of clear cell renal cell carcinomas
Authors: Chen Zhi , Ruan Weiqiang , Guo Chunhao , Chen Ke , Li Le , Tian Jihua , Hu Zhiquan , Peng Dan , Zeng Xing 
Published: January 2023

AbstractNon‐SMC condensin I complex subunit H (NCAPH) is reported to play an important role and be a poor prognostic factor in various cancers. However, the function and regulatory mechanism of NCAPH in clear cell renal cell carcinoma (ccRCC) remain unknown. The roles of NCAPH on ccRCC growth were detected in vitro and in vivo assays. The regulatory mechanism of NCAPH was explored by immunoprecipitation assay, ubiquitination assay, ChIP assay, RIP assay, luciferase reporter assay and RNA pull‐down assay. The role of NCAPH in immunoregulation also was explored by flow cytometry, T cell‐mediated tumour cell killing assay and immune‐competent mouse model. In this research, we displayed that NCAPH was upregulated in ccRCC and patients with elevated NCAPH expression had an undesirable prognosis. Functionally, NCAPH depletion restrained ccRCC growth in vitro and in vivo. The elevated NCAPH was attributed to FOXP3‐mediated transcription, FUS‐mediated transcription splicing and METTL3‐mediated m6A modification. Moreover, YTHDC1 promoted NCAPH mRNA nuclear export, and IGF2BP3 enhanced NCAPH mRNA stability in an m6A‐dependent manner. NCAPH increased PD‐L1 expression by inhibiting the degradation of β‐catenin in ccRCC cells, which further facilitated aerobic glycolysis and immune tolerance of ccRCC. Collectively, our findings display the vital function of NCAPH in ccRCC and uncover that NCAPH may be regarded as a potential therapeutic target to reverse the immune tolerance of ccRCC.
Home alone: Patterns and perceptions of solitary home alcohol consumption in an Australian convenience sample
Authors: Cook Megan , MacLean Sarah , Callinan Sarah 
Published: January 2023

AbstractIntroductionIn contrast with extensive literature exploring sociable alcohol use, few studies focus on drinking alone at home, even though the home is the place where the majority of drinking occurs.MethodsWe draw on survey and interview data gathered in 2018/2019 prior to the COVID‐19 pandemic, to identify prevalence and perceptions of solitary home drinking in an Australian convenience sample of heavy and light drinkers (LD).ResultsA substantial minority of survey participants identified drinking home alone, with over a quarter of heavy drinkers (27%) reporting that they only drank alone in their own home (compared to 15% of LD). In interviews, solitary home drinking was frequently constructed as signifying personal inadequacy, heavy consumption and harm. However, tensions arose through solitary home drinking bringing pleasures, such as relaxation. It was regarded as more socially acceptable for men than women and lighter home drinking patterns were viewed more positively than heavy drinking. Perceptions of what constitutes solitary home drinking varied, with some suggesting it includes drinking with others present who are not themselves drinking, and others using a more limited definition of consuming alcohol while alone in a house.Discussion and ConclusionsWhile strong social sanctions against it persist, solitary home drinking can reflect a lack of opportunity to drink with others and also be associated with more harmful regular patterns of alcohol use. Increasing recognition of home drinking provides a new imperative to better understand the complex stigmatisation that frames solitary home drinking and to explore opportunities to limit associated harms.
Fall in prevalence of impaired awareness of hypoglycaemia in individuals with type 1 diabetes
Authors: Ali Namam , El Hamdaoui Soumia , Schouwenberg Bas J. , Tack Cees J. , de Galan Bastiaan E. 
Published: January 2023

AbstractAimsImpaired awareness of hypoglycaemia (IAH) has been reported to affect up to a third of people with type 1 diabetes. Whether the increased use of sensor technology has changed its prevalence remains unknown. The aim of this study was to investigate the current prevalence of IAH and its change over time in a cohort of individuals with type 1 diabetes.MethodsIAH was assessed using the modified Clarke questionnaire in adults with type 1 diabetes. Participants were recruited from the diabetes outpatient clinic from February 2020 through April 2021. The scores were compared to similar data collected during previous assessments in 2006, 2010 and 2016 respectively.ResultsA total of 488 individuals (51.2% male) with a mean (±SD) age of 51.3 ± 15.9 years, median [Q1–Q3] diabetes duration of 30 [16–40] years and mean HbA1c of 60 ± 12 mmol/mol (7.7 ± 1.1%) were included. Sensors were used by 85% of the study population. IAH was present among 78 (16.0%) participants, whereas 86 (17.6%) participants had a history of severe hypoglycaemia. By comparison, the prevalence of IAH equalled 32.5% in 2006, 32.3% in 2010 and 30.1% in 2016 (p for trend <0.001), while the proportion of individuals reporting severe hypoglycaemia equalled 21.2%, 46.7% and 49.8% respectively (p for trend 0.010). Comparing sequential assessments over time, the proportion of individuals with persistent IAH decreased from 74.0% and 63.6% between 2006 and 2016 to 32.5% in 2020.ConclusionsAmong individuals with type 1 diabetes and high use of sensor technology, the current prevalence of IAH was 16%, about 50% lower as compared to previous years.
The decline of US manufacturing productivity between 1941 and 1948
Authors: Field Alexander J. 
Published: January 2023

AbstractThe view that war benefits potential output has been influential in treatments of US mobilization for the Second World War, where it has been largely premised on the benefits of learning by doing in producing military durables. If the thesis that war benefits aggregate supply is correct, it is indeed within manufacturing that we should most likely see its effects. Total factor productivity within the sector in fact fell at a rate of −1.4 per cent per year between 1941 and 1948, −3.7 per cent a year between 1941 and 1944, and −5.1 per cent a year between 1941 and 1945. The emphasis on learning by doing has obscured the negative effects of the sudden, radical, and temporary changes in the product mix, the behavioural pathologies accompanying the transition to a shortage economy, and the resource shocks inflicted on the country by the Japanese and Germans. From a long‐run perspective, the war can be seen, ironically, as the beginning of the end of US world economic dominance in manufacturing.
Inferring feeding habits of Carabidae (Coleoptera) larvae based on mandible morphology: Case studies of Lesticus magnus and Chlaenius costiger
Authors: Sasakawa Kôji 
Published: January 2023

AbstractIn the beetle family Carabidae, feeding habits are important life history traits that determine their role in ecosystems and suitability as bioindicators. However, they have not been elucidated for most species, especially in the larval stages. Using laboratory‐rearing experiments, this study examined the larval feeding habits of two large carabid species: Lesticus magnus (tribe Pterostichini) and Chlaenius costiger (tribe Chlaeniini). Although previous studies failed to rear these larvae on insect larva diets, the mandible morphology of the first instars described in those studies, together with subsequently obtained knowledge of the relationship between mandible morphology and feeding habits in other carabid larvae, suggests that they are earthworm feeders. Rearing experiments with three types of animal diet (insect larvae, mixed snail and slug, and earthworm diets) showed that as expected, their larvae are earthworm feeders. In L. magnus, although the larvae accepted the mixed snail and slug diet and the earthworm diet, only larvae reared on the earthworm diet reached adulthood. In C. costiger, the larvae accepted only the earthworm diet and reached adulthood. This is the first report of earthworm feeding during the larval stage for the genus Lesticus (tribe Pterostichini) and tribe Chlaeniini. The importance of these results is discussed from ecological and evolutionary perspectives.