bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric chronic graft-versus-host disease-related dry eye disease and the diagnostic association of potential clinical findings
Authors: Yagi Hitomi , Shimizu Eisuke , Yagi Ryuichiro , Uchino Miki , Kamoi Mizuka , Asai Kazuki , Tsubota Kazuo , Negishi Kazuno , Ogawa Yoko 
Published: March 2023

AbstractPediatric graft-versus-host-disease (GVHD)-related dry eye disease (DED) is often overlooked due to a lack of subjective symptoms and reliable testing, leading to irreversible corneal damage. To study the clinical findings contributing to the accurate detection of pediatric GVHD-related DED, a retrospective study of pediatric patients treated with hematopoietic stem cell transplantation (HSCT) at Keio University Hospital between 2004 and 2017 was conducted. Association and diagnostic values of ophthalmological findings for DED were analyzed. Twenty-six patients who had no ocular complications before HSCT were included in the study. Eleven (42.3%) patients developed new-onset DED. The cotton thread test showed excellent diagnostic accuracy in detecting DED (area under the receiver operating curve, 0.96; sensitivity, 0.95; specificity, 0.85) with a cut-off of 17 mm, which was higher than the conventional threshold of 10 mm. Additionally, the presence of filamentary keratitis (FK) and pseudomembranous conjunctivitis (PC) were significantly associated with the diagnosis of DED (p value, 0.003 and 0.001 for FK and PC, respectively) and displayed good diagnostic performance (sensitivity, 0.46 and 0.54; specificity, 0.97 and 0.97 for FK and PC, respectively). In conclusion, the cotton thread test with a new threshold, the presence of PC and FK, could be helpful for promptly detecting pediatric GVHD-related DED.
Efficacy and safety of angiogenesis inhibitors plus immune checkpoint inhibitors in advanced soft tissue sarcoma: a real-world, single-center study
Authors: Liu Zengjun , Xu Jing , Liu Mengyao , Hu Wenyu , Xu Ni , Zhu Dongyuan 
Published: March 2023

AbstractAngiogenesis inhibitors (AIs) and immune checkpoint inhibitors (ICIs) are new treatment options for advanced soft tissue sarcoma (STS) patients. This study evaluated the efficacy and safety of AIs plus ICIs in patients with advanced STS. A retrospective cohort study was performed on STS patients treated with AIs and ICIs at Shandong Cancer Hospital and Institute between August 2020 and December 2021. The primary endpoint was objective response rate (ORR); secondary endpoints included progression-free survival (PFS), disease control rate (DCR), overall survival (OS), and adverse events. Thirty-three patients were enrolled; 27 were evaluable for objective response. The ORR and DCR were 48.1% (95% CI 30.7–66.0%) and 85.2% (95% CI 67.5–94.1%). With a median follow-up of 7.6 months (range, 0.8–25.5), the median PFS for all 33 patients was 8.90 months (95% CI 5.98–11.82). The median OS was not reached. The most common treatment-related adverse events (TRAEs) of any grade were hypertension (50.0%), ECG T-wave abnormality (30.0%), hypothyroidism (26.7%), elevated alanine aminotransferase or aspartate aminotransferase (23.3%), elevated thyroid-stimulating hormone (23.3%), and fatigue (16.7%). The most common grade 3–4 TRAE was hypertension (27.3%). Three serious TRAEs (two myocarditis and one rapid atrial fibrillation) were recorded. This study suggests that adding AIs to ICIs is beneficial in STS.
The role of dung beetle species in nitrous oxide emission, ammonia volatilization, and nutrient cycling
Authors: García Carlos C. V. , Dubeux José C. B. , Martini Xavier , Conover Derick , Santos Erick R. S. , Homem Bruno G. C. , Ruiz-Moreno Martin , da Silva Izabela A. G. , Abreu Daciele S. , Queiroz Luana M. D. , van Cleef Flavia O. S. , Santos Mércia V. F. , Fracetto Giselle G. M. 
Published: March 2023

AbstractThis study evaluated the role of dung beetle species alone or associated under different species on nitrous oxide (N2O) emission, ammonia volatilization, and the performance of pearl millet [Pennisetum glaucum(L.)]. There were seven treatments, including two controls (soil and soil + dung without beetles), single species ofOnthophagus taurus[Shreber, 1759] (1),Digitonthophagus gazella[Fabricius, 1787] (2), orPhanaeus vindex[MacLeay, 1819] (3); and their assemblages (1 + 2 and 1 + 2 + 3). Nitrous oxide emission was estimated for 24 days, when pearl millet was planted in sequence to assess growth, nitrogen yield (NY), and dung beetle activity. Dung beetle species presented greater N2O flow of dung on the 6th day (80 g N2O-N ha−1 day−1) compared to soil and dung (2.6 g N2O-N ha−1 day−1). Ammonia emissions varied with the presence of dung beetles (P < 0.05), andD. gazellahad less NH3−N on days 1, 6, and 12 with averages of 2061, 1526, and 1048 g ha−1 day−1, respectively. The soil N content increased with dung + beetle application. Dung application affected pearl millet herbage accumulation (HA) regardless of dung beetle presence, and averages ranged from 5 to 8 g DM bucket−1. A PCA analysis was applied to analyze variation and correlation to each variable, but it indicated a low principal component explanation (less than 80%), not enough to explain the variation in findings. Despite the greater dung removal, the largest species,P. vindexand their species combination, need to be more studied to get a better understanding about their contribution on greenhouse gases. The presence of dung beetles prior to planting improved pearl millet production by enhancing N cycling, although assemblages with the three beetle species enhanced N losses to the environment via denitrification.
Astragalus-cultivated soil was a suitable bed soil for nurturing Angelica sinensis seedlings from the rhizosphere microbiome perspective
Authors: An Zhi-Gang , Guo Feng-Xia , Chen Yuan , Bai Gang , Guo Ai-Feng 
Published: March 2023

AbstractAngelica sinensis (Oliv.) Diels is an important Chinese medicinal plant. A. sinensis seedlings are grown on an undisturbed alpine meadow soil to ensure the high-quality seedlings, but these soils are disappearing year after year. Thus, selecting a suitable bed soil for A. sinensis seedlings could ensure their long-term sustainability. Using HiSeq sequencing of 16S and 18S marker genes, we investigated the rhizosphere bacterial and fungal microbiotas of the seedlings grown in wheat, astragalus, potato, and angelica-cultivated soils at a geo-authentic habitat. Co-occurrence network analysis, canonical correspondence analysis, Mantel test, and Envfit test were used to examine the relationship between the microbiotas and the surrounding factors. Astragalus-cultivated soils exhibited the following properties: the highest plant weight, the highest neighborhood connectivity in the bacterial network, the highest ratio of positive/negative relationship in both bacterial and fungal networks, the highest relative abundance of the arbuscular mycorrhizal fungi and the ectomycorrhizal fungi, the lowest relative abundance of Rhizoctonia solani, the suitable soil pH, and the close relationship between the rhizosphere microbiotas and the ecological factors. Moreover, each growth stage has its own major drivers in all crop-cultivated soils. Climate temperature and soil pH at 56 days after planting, precipitation at 98 days, and plant weight as well as microbial biomass C and N at 129 days were the major drivers of the bacterial and fungal microbiotas. Overall, the astragalus-cultivated soil was a suitable bed soil for nurturing A. sinensis seedlings to replace the undisturbed alpine meadow soils.
Elevated serum levels of bone morphogenetic protein-9 are associated with better outcome in AQP4-IgG seropositive NMOSD
Authors: Masuda Hiroki , Mori Masahiro , Uzawa Akiyuki , Uchida Tomohiko , Muto Mayumi , Ohtani Ryohei , Aoki Reiji , Kuwabara Satoshi 
Published: March 2023

AbstractLymphatic drainage in the central nervous system is regulated by meningeal lymphatic vasculature, and recurrent neuroinflammation alters lymphatic vessel remodeling. Patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD) were reported to demonstrate worse outcomes compared with patients with anti-myelin oligodendrocyte glycoprotein-associated disorders (MOGAD). This study aimed to investigate the serum cytokines relevant to vascular remodeling after attacks and their prognostic role in patients with AQP4 + NMOSD. This study measured the serum levels of 12 cytokines relevant to vascular remodeling, including bone morphogenetic protein-9 (BMP-9) and leptin, in 20 patients with AQP4 + NMOSD and 17 healthy controls (HCs). Disease controls included 18 patients with MOGAD. Serum and cerebrospinal fluid interleukin-6 levels were also measured. Clinical severity was evaluated with Kurtzke’s Expanded Disability Status Scale (EDSS). Compared with HCs, patients with AQP4 + NMOSD showed higher BMP-9 (median; 127 vs. 80.7 pg/mL; P = 0.0499) and leptin levels (median; 16,081 vs. 6770 pg/mL; P = 0.0224), but not those with MOGAD. Better improvement in EDSS at 6 months was associated with baseline BMP-9 levels in patients with AQP4 + NMOSD (Spearman’s rho =  − 0.47; P = 0.037). Serum BMP-9 is upregulated at relapse and may contribute to vascular remodeling in AQP4 + NMOSD. Serum BMP-9 levels could predict clinical recovery 6 months after the attack.
Prognosis after discontinuing renin angiotensin aldosterone system inhibitor for heart failure with restored ejection fraction after acute myocardial infarction
Authors: Lee Seung Hun , Rhee Tae-Min , Shin Doosup , Hong David , Choi Ki Hong , Kim Hyun Kuk , Park Taek Kyu , Yang Jeong Hoon , Song Young Bin , Hahn Joo-Yong , Choi Seung-Hyuck , Chae Shung Chull , Cho Myeong-Chan , Kim Chong Jin , Kim Ju Han , Kim Hyo-Soo , Gwon Hyeon-Cheol , Jeong Myung Ho , Lee Joo Myung ,   The KAMIR-NIH Investigators, Lee Seung Hun , Rhee Tae-Min , Shin Doosup , Hong David , Choi Ki Hong , Kim Hyun Kuk , Park Taek Kyu , Yang Jeong Hoon , Song Young Bin , Hahn Joo-Yong , Choi Seung-Hyuck , Chae Shung Chull , Cho Myeong-Chan , Kim Chong Jin , Kim Ju Han , Kim Hyo-Soo , Gwon Hyeon-Cheol , Jeong Myung Ho , Lee Joo Myung 
Published: March 2023

AbstractPrognostic effect of discontinuing renin–angiotensin–aldosterone-system-inhibitor (RAASi) for patients with heart failure (HF) after acute myocardial infarction (AMI) whose left ventricular (LV) systolic function was restored during follow-up is unknown. To investigate the outcome after discontinuing RAASi in post-AMI HF patients with restored LV ejection fraction (EF). Of 13,104 consecutive patients from the nationwide, multicenter, and prospective Korea Acute Myocardial Infarction-National Institutes of Health (KAMIR-NIH) registry, HF patients with baseline LVEF < 50% that was restored to ≥ 50% at 12-month follow-up were selected. Primary outcome was a composite of all-cause death, spontaneous MI, or rehospitalization for HF at 36-month after index procedure. Of 726 post-AMI HF patients with restored LVEF, 544 maintained RAASi (Maintain-RAASi) beyond 12-month, 108 stopped RAASi (Stop-RAASi), and 74 did not use RAASi (RAASi-Not-Used) at baseline and follow-up. Systemic hemodynamics and cardiac workloads were similar among groups at baseline and during follow-up. Stop-RAASi group showed elevated NT-proBNP than Maintain-RAASi group at 36-month. Stop-RAASi group showed significantly higher risk of primary outcome than Maintain-RAASi group (11.4% vs. 5.4%; adjusted hazard ratio [HRadjust] 2.20, 95% confidence interval [CI] 1.09–4.46, P = 0.028), mainly driven by increased risk of all-cause death. The rate of primary outcome was similar between Stop-RAASi and RAASi-Not-Used group (11.4% vs. 12.1%; HRadjust 1.18 [0.47–2.99], P = 0.725). In post-AMI HF patients with restored LV systolic function, RAASi discontinuation was associated with significantly increased risk of all-cause death, MI, or rehospitalization for HF. Maintaining RAASi will be necessary for post-AMI HF patients, even after LVEF is restored.
Analysis of contact pressure in a 3D model of dual-mobility hip joint prosthesis under a gait cycle
Authors: Tauviqirrahman Mohammad , Ammarullah Muhammad Imam , Jamari J. , Saputra Eko , Winarni Tri Indah , Kurniawan Febri Dwi , Shiddiq Shidnan Amir , van der Heide Emile 
Published: March 2023

AbstractHip joint prostheses are used to replace hip joint function in the human body. The latest dual-mobility hip joint prosthesis has an additional component of an outer liner that acts as a cover for the liner component. Research on the contact pressure generated on the latest model of a dual-mobility hip joint prosthesis under a gait cycle has never been done before. The model is made of ultrahigh molecular weight polyethylene (UHMWPE) on the inner liner and 316L stainless steel (SS 316L) on the outer liner and acetabular cup. Simulation modeling using the finite element method is considered static loading with an implicit solver for studying the geometric parameter design of dual-mobility hip joint prostheses. In this study, simulation modeling was carried out by applying varying inclination angles of 30°, 40°, 45°, 50°, 60°, and 70° to the acetabular cup component. Three-dimensional loads were placed on femoral head reference points with variations of femoral head diameter used at 22 mm, 28 mm, and 32 mm. The results in the inner surface of the inner liner, the outer surface of the outer liner, and the inner surface of the acetabular cup showed that the variations in inclination angle do not have a major effect on the maximum contact pressure value on the liner component, where the acetabular cup with an inclination angle of 45° can reduce contact pressure more than the other studied inclination angle variations. In addition, it was found that the 22 mm diameter of the femoral head increases the contact pressure. The use of a larger diameter femoral head with an acetabular cup configuration at a 45° inclination can minimize the risk of implant failure due to wear.
Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer
Authors: Gkika Eleni , Firat Elke , Adebahr Sonja , Graf Erika , Popp Ilinca , Radicioni Gianluca , Lo Simon S. , Nestle Ursula , Nicolay Nils H. , Niedermann Gabriele , Duda Dan G. , Grosu Anca-L. 
Published: March 2023

AbstractWe performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8+ cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67+CD8+ and Ki-67+CD4+ T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment.
Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade
Authors: Fox Douglas B. , Ebright Richard Y. , Hong Xin , Russell Hunter C. , Guo Hongshan , LaSalle Thomas J. , Wittner Ben S. , Poux Nicolas , Vuille Joanna A. , Toner Mehmet , Hacohen Nir , Boland Genevieve M. , Sen Debattama R. , Sullivan Ryan J. , Maheswaran Shyamala , Haber Daniel A. 
Published: March 2023

AbstractImmune checkpoint blockade (ICB) has demonstrated efficacy in patients with melanoma, but many exhibit poor responses. Using single cell RNA sequencing of melanoma patient-derived circulating tumor cells (CTCs) and functional characterization using mouse melanoma models, we show that the KEAP1/NRF2 pathway modulates sensitivity to ICB, independently of tumorigenesis. The NRF2 negative regulator, KEAP1, shows intrinsic variation in expression, leading to tumor heterogeneity and subclonal resistance.
PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment
Authors: Maresca C. , Dello Stritto A. , D’Angelo C. , Petti E. , Rizzo A. , Vertecchi E. , Berardinelli F. , Bonanni L. , Sgura A. , Antoccia A. , Graziani G. , Biroccio A. , Salvati E. 
Published: March 2023

AbstractTelomeres are nucleoprotein structures at eukaryotic chromosome termini. Their stability is preserved by a six-protein complex named shelterin. Among these, TRF1 binds telomere duplex and assists DNA replication with mechanisms only partly clarified. Here we found that poly (ADP-ribose) polymerase 1 (PARP1) interacts and covalently PARylates TRF1 in S-phase modifying its DNA affinity. Therefore, genetic and pharmacological inhibition of PARP1 impairs the dynamic association of TRF1 and the bromodeoxyuridine incorporation at replicating telomeres. Inhibition of PARP1 also affects the recruitment of WRN and BLM helicases in TRF1 containing complexes during S-phase, triggering replication-dependent DNA-damage and telomere fragility. This work unveils an unprecedented role for PARP1 as a “surveillant” of telomere replication, which orchestrates protein dynamics at proceeding replication fork.
Radiologic staging of peritoneal and retroperitoneal disease
Authors: Glockzin Gabriel , Helmberger Thomas 
Published: March 2023

Peritoneal and retroperitoneal tumors consist of a heterogenous group of benign and malignant lesions of different origin. Due to often complex multidisciplinary treatment concepts in patients with peritoneal surface malignancies radiological imaging plays a pivotal role regarding the therapeutic options. Moreover, tumor entity, abdominal tumor distribution and common as well as rare differential diagnoses have to be taken into account. Using different radiological modalities non-invasive pretherapeutic diagnostics might be significantly improved.
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Citation Format
Auswirkung von Mund-Nasen-Schutzmasken auf das Sprachverstehen bei normalhörigen Kindern
Authors: Taxacher Thomas , Rupp Martin , Pauli Christof , Profanter Carmen , Dejakum Klemens , Steindl Raluca , Ostertag Peter 
Published: March 2023

Zusammenfassung
Hintergrund Im Rahmen der Covid-19-Pandemie stellt der Mund-Nasen-Schutz (MNS) im Hinblick auf die Eindämmung der Pandemie ein einfaches und vergleichsweise kostengünstiges Mittel dar, das rasch flächendeckend eingesetzt werden kann. Ziel dieser Arbeit war es, die Auswirkung eines vom Sprecher getragenen Mund-Nasen-Schutz auf das Sprachverstehen von normalhörenden Kindern und Jugendlichen zu ermitteln.
Material und Methoden Bei 40 normalhörenden Kindern zwischen 10 und 18 Jahren wurde das Sprachverstehen anhand einer normierten audiologischen Testreihe (Freiburger Sprachtest, Einsilber) in Umgebungsruhe und im Störlärm (+ 25 dB SNR) überprüft, wobei der Sprecher über einen Bildschirm dargestellt wurde. Der Sprecher wurde gemäß der Versuchsanordnung mit bzw. ohne getragenem Mund-Nasen-Schutz gezeigt.
Ergebnisse Die Kombination des getragenen MNS des Sprechers mit der Wiedergabe im Störlärm ergab einen deutlichen Abfall des Sprachverstehens, wobei bei keinem Einzelfaktor ein signifikanter Einfluss gezeigt werden konnte.
Schlussfolgerungen Die Ergebnisse aus dieser Studie könnten zukünftig dazu beitragen, die Qualität des auf Fakten basierenden Entscheidungsprozess zur Auswahl der Instrumente, welche zur Eindämmung der Pandemie dienen sollen, zu erhöhen. Außerdem könnten die Ergebnisse als Basiswert herangezogen werden, um mit vulnerablen Gruppen der Gesellschaft, wie z.B. hörgeschädigten Kindern oder Erwachsenen, verglichen zu werden.
Hectogram-Scale Synthesis of Indobufen from Diludine-Triggered Metal-Free Cascade
Authors: Cheng Maosheng , Hua Yueting , Liu Bingxin , Cai Jiaxuan , Wang Tao 
Published: March 2023

AbstractIn this study, indobufen was successfully synthesized from diludine-triggered metal-free cascade in good yield. This process includes esterification, reduction, reductive amination/condensation cascade, hydrolysis, and recrystallization. Additionally, the post-treatment procedure was greatly simplified, and indobufen can be obtained by simple recrystallization that complies with the pharmacopoeia standards. Moreover, this work will be used as a basis for further research into the efficient production of indobufen on an industrial scale.
Imaging Recommendations for Diagnosis, Staging and Management of Treatment-Related Complications in Cancer
Authors: Mukhopadhyay Sumit , Sen Saugata , Ghosh Priya , Gehani Anisha , Patra Anurima , Chandra Aditi , Chatterjee Argha , Lingegowda Dayananda , Gupta Bharat , Gupta Meenu , Venugopal Prakash , Chakraborty Amrita , Pathak Ketul K. , Mishra Pradipta Kumar , Khoda Jeevitesh 
Published: March 2023

AbstractPrecision medicine is becoming increasingly common in oncology, with treatments tailored to individual patients and cancer. By integrating these underlying concepts of health care, chemotherapy and radiotherapy can be tailored to improve safety and efficacy. On the other hand, oncology treatment regimens may result in local and systemic changes and complications depending on the type of treatment. For the proper and prompt management of cancer patients, it is essential to interpret this posttreatment imaging correctly. This article aims at guiding treating physicians to be able to distinguish complications from expected posttreatment changes.
Imaging Recommendations for Diagnosis, Staging, and Management of Hepatic and Biliary Tract Cancer
Authors: Chatterjee Argha , Mukhopadhyay Sumit , Ghosh Priya , Shah Diva , Gehani Anisha , Baheti Akshay , Gupta Bharat , Chandra Aditi , Chaturvedi Arvind K. , Khoda Jeevitesh , Patra Anurima , Lingegowda Dayananda , Sen Saugata 
Published: March 2023

AbstractMajor hepatobiliary cancers include hepatocellular carcinoma, gallbladder carcinoma, and cholangiocarcinoma. There are multiple guidelines and recommendations for the imaging evaluation of these cancers. This article reviews and summarizes principles and recommendations of imaging in hepatobiliary cancers. The cross-sectional imaging protocol is similar among these lesions and is discussed at first followed by the separate discussion of each cancer.
Anthropometric Measurements of Hamstring Tendon Graft and Its Predictors in Ligament Reconstruction Surgeries of Knee: An Observational Study
Authors: Panigrahi Tapas Kumar , Maharaj Ramesh Chandra , Nanda Debi Prasad 
Published: March 2023

Introduction
Hamstring graft use has been in the forefront of ligament reconstruction around the knee. With the increasing number of surgeries, the complications are equally on the rise. One of the detrimental factors for predicting the outcome is the diameter and length of the graft. We did an observational study to find out the relationship of patient factors with the morphometry of the graft.

Materials and Methods
Total 484 patients were included in the study. Preoperatively, the age, sex, height, weight, and activity levels of the patients were noted. They were categorized into two major groups: physically active and inactive. The intraoperative measurements of the grafts were recorded. Analysis of variance for comparing the means of multiple groups was used for statistical analysis.

Results
Among the total 484 patients, 407 were male and 77 were female. The semitendinosus graft diameter did not show any statistical significance to the age and weight of the patient. The mean graft diameter was highest in the 45 to 49-year age group. The average graft diameter in physically active group was 3.704 mm, and 3.503 mm in the inactive group. This and the height of the patient proved to have statistically significant relation with graft diameter.

Conclusion
Physical activity along with the height of the patient must be taken into due consideration before embarking upon ligament reconstruction with hamstring graft in mind, as these two are found to determine the diameter and length of the hamstring graft.