bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brown midrib mutant and genome‐wide association analysis uncover lignin genes for disease resistance in maize
Authors: Kolkman Judith M. , Moreta Danilo E. , Repka Ace , Bradbury Peter , Nelson Rebecca J. 
Published: December 2022

AbstractBrown midrib (BMR) maize (Zea mays L.) harbors mutations that result in lower lignin levels and higher feed digestibility, making it a desirable silage market class for ruminant nutrition. Northern leaf blight (NLB) epidemics in upstate New York highlighted the disease susceptibility of commercially grown BMR maize hybrids. We found the bm1, bm2, bm3, and bm4 mutants in a W64A genetic background to be more susceptible to foliar fungal (NLB, gray leaf spot [GLS], and anthracnose leaf blight [ALB]) and bacterial (Stewart's wilt) diseases. The bm1, bm2, and bm3 mutants showed enhanced susceptibility to anthracnose stalk rot (ASR), and the bm1 and bm3 mutants were more susceptible to Gibberella ear rot (GER). Colocalization of quantitative trait loci (QTL) and correlations between stalk strength and disease traits in recombinant inbred line families suggest possible pleiotropies. The role of lignin in plant defense was explored using high‐resolution, genome‐wide association analysis for resistance to NLB in the Goodman diversity panel. Association analysis identified 100 single and clustered single‐nucleotide polymorphism (SNP) associations for resistance to NLB but did not implicate natural functional variation at bm1–bm5. Strong associations implicated a suite of diverse candidate genes including lignin‐related genes such as a β‐glucosidase gene cluster, hct11, knox1, knox2, zim36, lbd35, CASP‐like protein 8, and xat3. The candidate genes are targets for breeding quantitative resistance to NLB in maize for use in silage and nonsilage purposes.
The reversible impairment of behavioral variant frontotemporal brain sagging syndrome: Challenges and opportunities
Authors: Schievink Wouter I. , Maya Marcel , Barnard Zachary , Taché Rachelle B. , Prasad Ravi S. , Wadhwa Vikram S. , Moser Franklin G. , Nuño Miriam 
Published: December 2022

AbstractIntroductionDue to loss of brain buoyancy, spontaneous spinal cerebrospinal fluid (CSF) leaks cause orthostatic headaches but also can cause symptoms indistinguishable from behavioral variant frontotemporal dementia (bvFTD) due to severe brain sagging (including the frontal and temporal lobes), as visualized on brain magnetic resonance imaging. However, the detection of these CSF leaks may require specialized spinal imaging techniques, such as digital subtraction myelography (DSM).MethodsWe performed DSM in the lateral decubitus position under general anesthesia in 21 consecutive patients with frontotemporal dementia brain sagging syndrome (4 women and 17 men; mean age 56.2 years [range: 31–70 years]).ResultsNine patients (42.8%) were found to have a CSF‐venous fistula, a recently discovered type of CSF leak that cannot be detected on conventional spinal imaging. All nine patients underwent uneventful surgical ligation of the fistula. Complete or near‐complete and sustained resolution of bvFTD symptoms was obtained by all nine patients, accompanied by reversal of brain sagging, but in only three (25.0%) of the twelve patients in whom no CSF‐venous fistula could be detected (P = 0.0011), and who were treated with non‐targeted therapies.DiscussionConcerns about a spinal CSF leak should not be dismissed in patients with frontotemporal brain sagging syndrome, even when conventional spinal imaging is normal. However, even with this specialized imaging the source of the loss of spinal CSF remains elusive in more than half of patients.
Non‐cytopathic bovine viral diarrhoea virus 2 induces autophagy to enhance its replication
Authors: Shin Seung‐Uk , Han Du‐Gyeong , Cho Hyung‐Chul , Kim Eun‐Mi , Choi Kyoung‐Seong 
Published: December 2022

AbstractBackgroundBovine viral diarrhoea virus (BVDV) is an important viral pathogen that has an economic impact on the livestock industry worldwide. Autophagy is one of the earliest cell‐autonomous defence mechanisms against microbial invasion, and many types of viruses can induce autophagy by infecting host cells.ObjectivesThe aim of this study was to identify the role of autophagy in the pathogenesis of non‐cytopathic (ncp) BVDV2 infection.MethodsMadin–Darby bovine kidney (MDBK) cells were treated with ncp BVDV2, rapamycin, or 3‐methyladenine (MA) and ncp BVDV2 and then incubated at 37°C for 24 h. Cells were harvested, and the effects of autophagy were determined by transmission electron microscopy (TEM), confocal laser microscopy, western blotting and qRT‐PCR. Apoptotic analysis was also performed using western blotting and flow cytometry.ResultsIn ncp BVDV2‐infected MDBK cells, more autophagosomes were observed by TEM, and the number of microtubule‐associated protein 1 light chain 3B (LC3B) with green fluorescent protein puncta was also increased. The ncp BVDV2‐infected cells showed significantly enhanced conversion of LC3‐I to LC3‐II, as well as upregulation of autophagy‐related proteins, including ATG5 and Beclin 1, and substantial degradation of p62/SQSTM1. These results are similar to those induced by rapamycin, an autophagy inducer. E2 protein expression, which is associated with viral replication, increased over time in ncp BVDV2‐infected cells. Inhibition of autophagy by 3‐MA in ncp BVDV2‐infected MDBK cells downregulated the expressions of LC3‐II, ATG5 and Beclin 1 and prevented the degradation of p62/SQSTM1. Moreover, the expressions of phosphorylated Akt and procaspase‐3 were significantly increased in ncp BVDV2‐infected cells. In addition, the mRNA level of protein kinase R (PKR) was significantly reduced in ncp BVDV2‐infected cells.ConclusionsOur results demonstrate that ncp BVDV2 infection induced autophagy in MDBK cells via anti‐apoptosis and PKR suppression. Therefore, autophagy may play a role in establishing persistent infection caused by ncp BVDV.
Migrant Perspectives on External Voting
Authors: Szulecki Kacper , Erdal Marta Bivand , Stanley Ben 
Published: December 2022

AbstractThis chapter explores migrants’ perspectives on voting in country-of-origin elections and on participation in democratic politics in countries of origin in Central and East Europe. We build on 80 semi-structured interviews with migrants from Poland and Romania, living in Barcelona, Spain, and Oslo, Norway. The chapter offers an analysis of their thoughts on and experiences of practicing external voting, as well as choosing not to cast a ballot in any given election. The first part explores the reasons why migrants do—or do not—vote “back home,” offering illustrations from our data, focusing on motivations for external voting, practicalities that impede or facilitate external voting, and discussing intersecting scales of motivation. These discussions are set within the context of migrants’ broader motivations to engage in politics transnationally, and intimately connected with their reflections on the principled question of the democratic legitimacy of external voting. The second part of the chapter extends the view from external voting to migrants’ own perspectives on transnational political engagement, including but not limited to external voting, as set within often transnational lifeworlds affected by both “here” and “there” in varying ways.
Trends in polytrauma incidence among major trauma admissions
Authors: Hardy Benjamin Maurice , King Kate Louise , Enninghorst Natalie , Balogh Zsolt Janos 
Published: December 2022

Abstract
Purpose
Polytrauma is increasingly recognized as a disease beyond anatomical injuries. Due to population growth, centralization, and slow uptake of preventive measures, major trauma presentations in most trauma systems show a slow but steady increase. The proportional contribution of polytrauma patients to this increase is unknown.

Methods
A 13-year retrospective analysis ending 31/12/2021 of all major trauma admissions (ISS > 15) to a level-1 trauma center were included. Polytrauma was classified using the Newcastle definition. Linear regression analysis was used to compare the rates of patient presentation over time. Logistic regression was used to measure for change in proportion of polytrauma. Data are presented as median (IQR), with odds ratios and 95% confidence intervals as appropriate.

Results
5897 (age: 49 ± 43 years, sex: 71.3% male, ISS: 20 ± 9, mortality: 10.7%) major trauma presentations were included, 1,616 (27%) were polytrauma (age: 45 ± 37 years, 72.0% male, ISS: 29 ± 14, mortality: 12.7%). Major trauma presentations increased significantly over the study period (+ 8 patients per year (3–14), p < 0.01), aged significantly (0.42 years/year (0.25–0.59, p < 0.001). The number of polytrauma presentations per year did not change significantly (+ 1 patients/year (– 1 to 4, p > 0.2). Overall unadjusted mortality did not change (OR 0.99 (0.97–1.02). Polytrauma mortality fell significantly (OR 0.96 (0.92–0.99)) over the study period.

Conclusions
Polytrauma patients represent about 25% of the major trauma admissions, with higher injury severity, static incidence and higher but improving mortality in comparison to all major trauma patients. Separate reporting and focused research on this group are warranted as monitoring the entire major trauma cohort does not identify these specifics of this high acuity subgroup.
Identifying and prioritizing educational content from a malpractice claims database for clinical reasoning education in the vocational training of general practitioners
Authors: van Sassen Charlotte G. M. , van den Berg Pieter J. , Mamede Silvia , Knol Lilian , Eikens-Jansen Manon P. , van den Broek Walter W. , Bindels Patrick J. E. , Zwaan Laura 
Published: December 2022

AbstractDiagnostic reasoning is an important topic in General Practitioners’ (GPs) vocational training. Interestingly, research has paid little attention to the content of the cases used in clinical reasoning education. Malpractice claims of diagnostic errors represent cases that impact patients and that reflect potential knowledge gaps and contextual factors. With this study, we aimed to identify and prioritize educational content from a malpractice claims database in order to improve clinical reasoning education in GP training. With input from various experts in clinical reasoning and diagnostic error, we defined five priority criteria that reflect educational relevance. Fifty unique medical conditions from a malpractice claims database were scored on those priority criteria by stakeholders in clinical reasoning education in 2021. Subsequently, we calculated the mean total priority score for each condition. Mean total priority score (min 5–max 25) for all fifty diagnoses was 17,11 with a range from 13,89 to 19,61. We identified and described the fifteen highest scoring diseases (with priority scores ranging from 18,17 to 19,61). The prioritized conditions involved complex common (e.g., cardiovascular diseases, renal insufficiency and cancer), complex rare (e.g., endocarditis, ectopic pregnancy, testicular torsion) and more straightforward common conditions (e.g., tendon rupture/injury, eye infection). The claim cases often demonstrated atypical presentations or complex contextual factors. Including those malpractice cases in GP vocational training could enrich the illness scripts of diseases that are at high risk of errors, which may reduce diagnostic error and related patient harm.
Fake news on Facebook and their impact on supply chain disruption during COVID-19
Authors: Hossain Mohammad Alamgir , Chowdhury Md. Maruf Hossan , Pappas Ilias O. , Metri Bhimaraya , Hughes Laurie , Dwivedi Yogesh K. 
Published: December 2022

AbstractSocial media (SM) fake news has become a serious concern especially during COVID-19. In this study, we develop a research model to investigate to what extent SM fake news contributes to supply chain disruption (SCD), and what are the different SM affordances that contribute to SM fake news. To test the derived hypotheses with survey data, we have applied partial least square based structural equation modelling (PLS-SEM) technique. Further, to identify how different configurations of SC resilience (SCR) capabilities reduce SCD, we have used fuzzy set qualitative comparative analysis (fsQCA). The results show that SM affordances lead to fake news, which increases consumer panic buying (CPB); CPB in turn increases SCD. In addition, SM fake news directly increases SCD. The moderation test suggests that, SCR capability, as a higher-order construct, decreases the effect of CPB on SCD; however, neither of the capabilities individually moderates. Complimentarily, the fsQCA results suggest that no single capability but their three specific configurations reduce SCD. This work offers a new theoretical perspective to study SCD through SM fake news. Our research advances the knowledge of SCR from a configurational lens by adopting an equifinal means towards mitigating disruption. This research will also assist the operations and SC managers to strategize and understand which combination of resilience capabilities is the most effective in tackling disruptions during a crisis e.g., COVID-19. In addition, by identifying the relative role of different SM affordances, this study provides pragmatic insights into SM affordance measures that combat fake news on SM.
A Rating Framework for the Quality of Video Explanations
Authors: Ring Malte , Brahm Taiga 
Published: December 2022

AbstractMore and more teachers create video explanations for their instruction. Whether or not they are effective for learning depends on the videos’ instructional quality. Reliable measures to assess the quality of video explanations, however, are still rare, especially for videos created by (preservice) teachers. We developed such a measure in a two-step process: First, the categories were theoretically derived. Second, a coding manual was developed and used with 36 videos, which were created by preservice teachers during a university seminar. The resulting framework, which can be used as a coding manual for future research, consists of twelve criteria in five different categories: video content, learner orientation, representation and design, language, and process structure. With this framework, we contribute a reliable measure to evaluate the quality of existing videos. In practice, teachers can also use this measure as a guideline when creating or choosing video explanations for the classroom.
Finite element analysis of changes in tensile strain and deformation by airbag impact in eyes of various axial lengths
Authors: Kobayashi Ayaka , Izaki Ryosuke , Fujita Hideaki , Harada Kazuhiro , Ozaki Hiroaki , Kadonosono Kazuaki , Uchio Eiichi 
Published: December 2022

Abstract
Purpose
Airbags have substantially reduced mortality and morbidity, while ocular injuries caused by airbags have been reported. We applied a three-dimensional finite element analysis (FEA) model we have established for evaluation of the deformation of an intact eyeball of various axial lengths induced by an airbag impact at various impact velocities.

Methods
A model human eye we have created was used in simulations with an FEA program, PAM-GENERIS™ (Nihon ESI, Tokyo, Japan). The airbag was set to impact eyes with various axial lengths of 21.85 mm (hyperopia), 23.85 mm (emmetropia) and 25.85 mm (myopia), at initial velocities of 30, 40, 50 and 60 m/s. Changes in the shape of the eye and the strain induced were calculated. Deformation of the eye in a cross-sectional view was displayed sequentially in slow motion.

Results
We found that considerable damage, such as corneal or scleral lacerations, was observed especially at higher impact velocities, such as 50 or 60 m/s, in eyes with any axial length. Deformation was most evident in the anterior segment. The decrease rate of axial length was greatest in the hyperopic eye, followed by the myopic eye, and the emmetropic eye.

Conclusions
It was shown that hyperopic eyes are most susceptible to deformation by an airbag impact in this simulation. The considerable deformation by an airbag impact on the eye during a traffic accident shown in this study might indicate the necessity of ocular protection to avoid permanent eye damage.
Reference the untouchable. On the limits of revising concepts using the method of cases
Authors: Sękowski Krzysztof 
Published: December 2022

AbstractThe paper investigates to what extent the method of cases can be interpreted as either a descriptive or a normative enterprise. I demonstrate that although most instances of the method of cases in most philosophical theories could be interpreted as being intended to either discover or revise the meaning of their target concepts, within a theory of reference this method cannot be used to shift the meaning of the concept of reference. The reason for this is that intuitions of extension in a theory of reference constitute a set of data that needs to be explained, while in most other philosophical theories they could either be abandoned in favor of intuitions of intension or serve as a criterion for the adequacy of the proposed definition of the target concept. This feature of a theory of reference is caused by the fact that an implicit understanding of what reference is in a theory of reference is usually assumed and is out of discussion. In effect, the claim in paradigmatic instances of the method of cases within a theory of reference does not concern whether an expression does or does not refer in particular cases, but rather what the reference of a certain expression is, and therefore it cannot be justified by intuitions of intension.
Using commonly-available technologies to create online multimedia lessons through the application of the Cognitive Theory of Multimedia Learning
Authors: Cavanagh Thomas M. , Kiersch Christa 
Published: December 2022

AbstractPrinciples derived from the Cognitive Theory of Multimedia Learning (CTML; Mayer in: Multimedia learning, Cambridge University Press, Cambridge, 2021) provide valuable guidance for enlisting commonly-available technologies to create effective online multimedia lessons. Specifically, CTML can guide instructional designers on the use of slide-sharing programs to create concise, narrated animation segments; the use of survey programs to interpolate questions and prompts between these segments to facilitate generative learning activities; and the use of video-sharing sites to provide learners with control over relatively superficial aspects of instruction. The application of CTML to the design of online multimedia lessons raises a number of theoretical and practical questions, including the need to better understand the relationship between working memory capacity and working memory duration, the importance of retrieval as a learning process, and the relative impact of selection and organization processes on learning.
Affix polyfunctionality in French deverbal nominalizations
Authors: Salvadori Justine , Huyghe Richard 
Published: December 2022

AbstractThis article investigates the semantic polyfunctionality of affixes, i.e. their ability to serve a variety of distinct semantic functions. Based on the analysis of a sample of 3,091 deverbal nouns ending with 46 different suffixes in French, the study examines the diversity of semantic functions realized by deverbal suffixes, the distribution of these functions across suffixes and the relationships that may exist between different functions. It appears that polyfunctionality is widespread among French deverbal suffixes and involves a large number of semantic functions, with highly variable realization frequency. Several fundamental aspects of affix polyfunctionality are further highlighted. A probabilistic analysis shows that polyfunctionality can be driven by non-arbitrary semantic associations between functions. A hierarchy of functions can also be postulated depending on whether they can be instantiated by monosemous or only polysemous derivatives. In addition, polyfunctionality appears to be inseparable from rivalry relationships and to determine the degree of rivalry between affixes. Overall, the study illustrates that affix polyfunctionality is governed by systematic organizing principles whose ramifications touch on lexical ambiguity and morphological competition.
Organic photodiodes: device engineering and applications
Authors: Shan Tong , Hou Xiao , Yin Xiaokuan , Guo Xiaojun 
Published: December 2022

AbstractOrganic photodiodes (OPDs) have shown great promise for potential applications in optical imaging, sensing, and communication due to their wide-range tunable photoelectrical properties, low-temperature facile processes, and excellent mechanical flexibility. Extensive research work has been carried out on exploring materials, device structures, physical mechanisms, and processing approaches to improve the performance of OPDs to the level of their inorganic counterparts. In addition, various system prototypes have been built based on the exhibited and attractive features of OPDs. It is vital to link the device optimal design and engineering to the system requirements and examine the existing deficiencies of OPDs towards practical applications, so this review starts from discussions on the required key performance metrics for different envisioned applications. Then the fundamentals of the OPD device structures and operation mechanisms are briefly introduced, and the latest development of OPDs for improving the key performance merits is reviewed. Finally, the trials of OPDs for various applications including wearable medical diagnostics, optical imagers, spectrometers, and light communications are reviewed, and both the promises and challenges are revealed.
Graphical Abstract