bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of BDNF, NTRK2, NGFR, CREB1, GSK3B, AKT, MAPK1, MTOR, PTEN, ARC, and SYN1 Genetic Polymorphisms in Antidepressant Treatment Response Phenotypes
Authors: Santos Marlene , Lima Luis , Carvalho Serafim , Mota-Pereira Jorge , Pimentel Paulo , Maia Dulce , Correia Diana , Barroso M. Fátima , Gomes Sofia , Cruz Agostinho , Medeiros Rui 
Published: April 2023

This study aimed to investigate the influence of genetic variants in neuroplasticity-related genes on antidepressant treatment phenotypes. The BDNF-TrkB signaling pathway, as well as the downstream kinases Akt and ERK and the mTOR pathway, have been implicated in depression and neuroplasticity. However, clinicians still struggle with the unpredictability of antidepressant responses in depressed patients. We genotyped 26 polymorphisms in BDNF, NTRK2, NGFR, CREB1, GSK3B, AKT, MAPK1, MTOR, PTEN, ARC, and SYN1 in 80 patients with major depressive disorder treated according to the Texas Medical Algorithm for 27 months at Hospital Magalhães Lemos, Porto, Portugal. Our results showed that BDNF rs6265, PTEN rs12569998, and SYN1 rs1142636 SNP were associated with treatment-resistant depression (TRD). Additionally, MAPK1 rs6928 and GSK3B rs6438552 gene polymorphisms were associated with relapse. Moreover, we found a link between the rs6928 MAPK1 polymorphism and time to relapse. These findings suggest that the BDNF, PTEN, and SYN1 genes may play a role in the development of TRD, while MAPK1 and GSK3B may be associated with relapse. GO analysis revealed enrichment in synaptic and trans-synaptic transmission pathways and glutamate receptor activity with TRD-associated genes. Genetic variants in these genes could potentially be incorporated into predictive models of antidepressant response.
Implicaciones teóricas de la administración financiera
Authors: Vázquez-Vidal Verónica 
Published: April 2023

La administración financiera es cuya diciplina se encarga de la planificación, organización y control de los recursos financieros, es decir, se encarga de las tomas de decisiones sobre financiamientos, inversiones, ahorros y presupuestos, etcétera. Pues sus implicaciones consisten en obtener una función operativa dedicada a la estructura, la gestión de la liquidez y los activos financieros en materia. Para poder entenderla es necesario hacer hincapié en la finalidad que tiene la misma, esta es la planificación, la cual se encargará de aquellos acuerdos económicos a largo y corto plazo, con el fin de reducir riesgos y con ello incrementar el valor de la compañía, tomando en cuenta el desarrollo del mercado, por ende, incluye todas las decisiones financieras de inversión, como lo son la financiación, programación y control de proyectos de inversión, políticas en inversión entre otras.
Los objetivos de la administración financiera incluyen principalmente el mantenimiento de los recursos, entender y manejar de forma óptima los riesgos (principalmente en las inversiones), buscar la maximización de las utilidades o ingresos y finalmente, el mejoramiento de la utilización de los recursos financieros ya sean de un particular o de una empresa.
El presente articulo nos permitirá conocer los conocimientos básicos de “las implicaciones teóricas de la administración financiera”, para así implementar un plan de acción a la hora de hacer inversiones, y con ello la planificación adecuada para la mejora de los gastos, de forma tal que se cree un buen presupuesto y se maximicen las utilidades. Los recursos financieros de la empresa son fundamentales, de ello la idea que un buen manejo de estos lleve al éxito, dentro de la administración financiera se maneja el estudio eficiente del dinero.
Intersectional Discrimination in European Labour Markets in the Voices of TCN Women
Authors: Martinho Ana , Zabulaite Egle , Kosta Antrea , Fernandes Joana , Fernandes Tiago , Bernardino Susana , Querido Joana , Salazar Helena , Costescu Alis , Liopetriti Anastasia , Amprazis Apostolos , Maini Dana , Stefas George , Bakali Magda , Quartararo Sara , Saaristo Meri , Chrysostalis Manolis , Marthins Marylyn 
Published: April 2023

Despite migration being a universal and secular phenomenon, recent studies and latest statistics show that unemployment among third-country nationals aged between 15 and 64 years old is generally higher than the rate among the overall population (76% among newcomers). Within this context, the current study aims to find out common patterns concerning the barriers that Third Country National (TCN) Women face in the host labour market and facilitating factors they used to cross them. The current research is supported by a qualitative methodology, based on 74 interviews to women from nine European countries and the analysis of 11 success stories. The interviewees have a very heterogeneous sociodemographic profile, concerning age, country of origin, host country and educational background. Despite some TCN women being employed, most are currently unemployed or in precarious condition. Our study proposes a four-fold categorisation of barriers faced by TCN women: i) cultural and linguistic; ii) diplomas; iii) support system; iv) discrimination. The lack of language skills was mentioned by almost all the women interviewed because free or easily affordable courses are limited.The second category of barriers entails the complexity of recognising academic qualifications and working experience from their home countries. The lack of a supporting system has impact in different dimensions of social and professional inclusion. The last category represents a large number of dimensions, related to an intersectional discrimination based on gender, race and religion. Regarding the facilitating factors that 11 women with integration success stories shared, we would highlight: i) the role and importance of Social and Solidarity migrant organisations as a support for TCN women; ii) the recognition the added-value of TCN women skills, such as being proficient in several foreign languages; iii) the empowerment of success stories reported by the storyteller herself and by other women in a similar situation; iv) the resilience to not give up, despite a considerable amount of obstacles.
Perspectives on gender mainstreaming in international cooperation in STI: A comparative study
Authors: Gursch Sarina , Ayciriex Luciana , Ursa Yolanda , Kutschera Stefan , Slany Wolfgang , Onuki Janina , Ferreira Gabriela 
Published: April 2023

Gender equality is the fifth Sustainable Development Goals (SDGs) goal. However, there are still global gaps to be addressed for leveraging science, technology, and innovation (STI) for achieving this goal. Countries and governments at all levels need to effectively utilize STI to help mobilize the global community to assist in gender mainstreaming.
International cooperation encompasses a great diversity of countries, regions, dominant religions, and cultures in broad terms – and this is undoubtedly a relevant hinderance to a gender equality narrative. Even within most homogeneous areas, such as the European countries, different levels of awareness on gender issues still prevail, impacting the practical relevance of the problem. Many gender-related projects, actions, and policies aim to counteract this. However, there is no clear guidance on what is expected from the institutions about addressing gender equality to mainstream gender into international dialogues. Therefore, gender equality runs the risk of remaining a “good intention”. In addition, there is little explicit data on the gender dimension in international agreements.
The design for this study includes qualitative and quantitative data collected in the EU Horizon 2020 Gender STI. The framework is developed based on three main data sources collected from semi-structured interviews, an online survey, and a mapping exercise on gender equality in STI agreements in different regions worldwide. These sources, collected from more than 60 countries worldwide, allow data triangulation to validate the qualitative insights related to gender mainstreaming in STI.
This paper offers critical insights on gender mainstreaming in international dialogues, which are becoming an essential instrument of change if cultural differences are considered. The institutional profile and professional culture are relevant to define each gender balance action's range and foster data production on the subject. Moreover, recent requirements in European funding instruments, such as Horizon Europe, have a broad impact on the international cooperation landscape, inducing a general institutional change and a reverse cultural bias.
Place-Based Solutions for Net Zero: Gender Considerations on ‘Green’ Skills
Authors: Mininni Giulia M. , Hiteva Ralitsa 
Published: April 2023

There is a global effort towards transitioning to a zero or low-carbon economy due to climate change and the current energy crises. This requires a shift in socio-technical systems and cross collaboration amidst sectors. The move to a clean energy-based economy also involves the creation of a broad range of skills, the upskilling and reskilling of the existing workforce, and providing opportunities for training. While many critical analyses of emerging decarbonisation or green skills, focus on issues of clean energy transition and the distribution of opportunities between fossil fuel-based and clean energy industries, there is limited critical analysis of justice and equality regarding the distribution of opportunities for developing key green skills for place-based decarbonisation.
There is evidence of asymmetric power relations and gender inequalities regarding the acquisition of skills, employment opportunities, kinds of jobs and pay gap which disproportionately affect women. This paper presents compelling evidence of hegemonic masculinisation within the energy industry; this tendency is now mirrored in ecological industries and technologies, including within the renewable energy sector, leading to an ‘eco-masculinisation’ of the sector.
Just transition principles promote a fair distribution of resources and the representation of vulnerable groups, including women and minorities. By relying on local assets and resources, including human resources, place-based approaches to green skills could address local communities’ needs while strengthening their resilience. These processes are pivotal to a fair and equitable transition. By explicitly articulating the context of place in understanding the gender(ed) dynamics of decarbonisation and skills, the authors identify and reflect on an innovative way of understanding the intersections between infrastructures, skills, and masculinisation in the transition to low zero carbon.
FGM (Female Genital Mutilation) Health Support for Non-Pregnant Women: Evaluation Findings From the NHS Pilot Programme
Authors: Warwick-Booth Louise , Starks Louise 
Published: April 2023

There has been little progress in meeting the needs of non-pregnant women with FGM, who might seek medical help in the UK. The NHS funded eight FGM clinics for non-pregnant women across England, 2019-2021. The aim of our evaluation was to test how effective/capable these clinics were in meeting the health and wellbeing needs of women who are not pregnant but have experienced FGM. Our evaluation documented each of the various models of service delivery across the eight commissioned delivery sites, capturing evidence of what works to improve the health and wellbeing of women using these services. Within this we explored the importance of delivering clinics within community settings. We also examined the effectiveness of various staff roles (lead clinician, health advocate and therapist) across each clinic to understand the holistic approach used to deliver services. We captured the views of a small number of service users through individual interviews, to include their lived experiences of FGM and attending the clinic in our data. The main aim of the evaluation was to determine whether the clinics improved the health outcomes of non-pregnant survivors of FGM.

This paper presents findings from the qualitative research component of the evaluation. Drawing upon interview data from 42 professionals as well as 12 service users, we summarise our key findings here. We detail the model of support (community service delivery, with trusted professionals, creating a safe space) and the learning gained from the pilot implementation. Positive outcomes include improved health and well-being for women (mental and physical health improvements). Challenges in service delivery included language barriers, how professionals reach into communities, the stigma associated with FGM as an experience, and mental health problems arising from FGM.
Pengaruh Kombinasi Pupuk Kandang Kotoran Puyuh dan NPK Terhadap Pertumbuhan Dan Hasil Tanaman Selada (Lactuca Sativa L.) Varietas Grand Rapids
Authors: Lutfiana Ahmad Latif , Sondari Nunung , Sufiadi Endang , Ulfah Indriana 
Published: April 2023

Artikel ini bertujuan untuk mempelajari pengaruh kombinasi pupuk kandang kotoran puyuh dan NPK (16-16-16) terhadap pertumbuhan dan hasil tanaman selada, serta mempelajari dosis yang terbaik yang memberikan pertumbuhan dan hasil terbaik tanaman selada. Percobaan dilaksanakan di Balai Penelitian Tanaman Sayuran (BALITSA) Cikole, Lembang, Kabupaten Bandung Barat dengan ketinggian tempat 1250 meter diatas permukaan laut dengan ordo tanah Andisol. Waktu percobaan dilakukan pada bulan April sampai dengan Juni 2020. Rancangan lingkungan yang digunakan adalah Rancangan Acak Kelompok (RAK) sederhana yang terdiri dari sepuluh perlakuan yaitu Tanpa pupuk, 7.5 ton ha-1 Pupuk kandang kotoran (PKK) puyuh, 15 ton ha-1 PKK puyuh, 22.5 ton ha-1 PKK puyuh, 30 tonÂ ha-1 PKK puyuh, 400 kg ha-1 NPK (16-1616), 7.5 ton ha-1 PKK puyuh + 200 kg ha-1 NPK, 15 ton ha-1 PKK puyuh + 200 kg ha-1 NPK, 22.5 ton ha-1 PKK puyuh + 200 kg ha-1 NPK, 30 ton ha-1 PKK puyuh + 200 kg ha-1 NPK dan masing masing diulang tiga kali. Hasil percobaan menunjukkan bahwa kombinasi pupuk kandang kotoran puyuh dan NPK berpengaruh nyata terhadap seluruh variabel kecuali terhadap variabel nisbah pupus akar. Pada variabel bobot bersih per plot perlakuan C, D, G, H dan I menunjukkan hasil berbeda nyata lebih tinggi. Hasil tertinggi ditunjukkan pada perlakuan D (22.5 ton ha-1 Pupuk kandang kotoran puyuh)Â dengan bobot 4262.83 gram/m2 atau setara dengan 42,6 ton ha-1.Â
EVALUASI TUTUPAN LAHAN PASCA PENETAPAN KAWASAN TAMAN BURU MASIGIT KAREUMBI (TBMK) BERBASIS SISTEM INFORMASI GEOGRAFIS
Authors: Luth Fahriza , Susila Rian , Fahmi Raizal , Pasecha Kilana 
Published: April 2023

Masigit Kareumbi Game Park (Taman Buru Masigit Kareumbi or TBMK) is a conservation forest that can be used to accomodate game tourism with 12.42070 ha area. In 1998, PT. Prima Multi Sarana (PMS) was given permission to conduct pine resin extraction in 2005 in TBMK area of PT. PMS; however they disobeyed the code of conduct by taking away the wood forest products (Hasil Hutan Kayu or HHK) causing forest damage that leading to the change of land cover in TBMK area. The purpose of this research is to find out how much change of land cover in TBMK after the game park establishment, and the factors that affect the change. This study used spatial data method with SIG system and Snowball Sampling technique in getting respondents’ samples. The result showed that TBMK in Cimanggung Adminiatrative Area had 468,66 ha land cover change in each closing type area from 1997 to 2017. The factors that cause the change of land cover in TBMK are the misuse of permission by PT. PMS, farmers activities in the area, unsettled area border, the lack of area guard and the socialization for the villagers, and the weakness of law enforcement
حرية الاعلام في الحصول على المعلومات الحكومية
Authors: أنعام عبد الرضا سلطان  
Published: April 2023

يخضع الحصول على المعلومات الى مد وجزر في اية دولة ؛ غير انعملية التحول قد بدأت ولم يعد من الممكن أخبار المواطنين ان المعرفة لا تحقلهم.
لقد بدأ عهد جديد من الشفافية الحكومية. فبات من المعروف بشكل واسعاليوم ان ثقافة السرية التي كانت تشكل طريقة عمل الحكومات على امتدادسنوات لم تعد قابلة للتطبيق في عصر عالمي من المعلومات وبالتالي منالضروري على الحكومات في عصر المعلومات أن تقدم المعلومات في سبيلالنجاح.
تعتبر القوانين التي تفتح السجلات والعمليات الحكومية شائعة اليوم فيالدول الديمقراطية فقد اعتمدت خمسون دولة تقريبا قوانين شاملة لتسهيلالوصول الى المعلومات فيما تستعد ثلاثون غيرها للدخول في هذه العملية .وتتشابه هذه القوانين بشكل واسع وهي تتيح للمواطنين والمقيمين واي شخصغالبا بموجب الحق العام المطالبة بالمعلومات من الهيئات الحكومية ؛ لكنتتوافر أستثناءات تمكن من الاحتفاظ بالمعلومات السرية .
اتجاهات ذوي المرضى النفسيين (العصابين والذهانين) وغير ذوي المرضى النفسيين نحو المرض النفسي وعلاقتها ببعض المتغيرات
Authors: د. حسين مد الله الطراونة  
Published: April 2023

هدفت الدراسة إلى استقصاء اثر كل من جنس الفرد ومستواه التعليمي من ذوي أو من غير ذوي المريض النفسي ونوع المرض النفسي على الاتجاهات نحو المرض النفسي .
ولغايات هذه الدراسة طبق مقياس الاتجاهات نحو المرض النفسي لكوهين وسترونج الذي تم تعديله إلى العربية من قبل (بومين 1989) على عينة مكونة من 730 فردا من ذوي وغير ذوي المرضى النفسيين.
كشفت نتائج الدراسة عن أن اتجاهات أفراد المجتمع الأردني نحو المرض النفسي كانت ايجابية نوعا ما مع عدم وجود اثر ذي دلالة إحصائي عند (0.05=a).
أما بخصوص المستوى التعليمي فقد أشارت النتائج إلى أن اتجاهات الأفراد ذوي المستوى التعليمي العالي والمتوسط كانت أكثر ايجابية من اتجاهات الأفراد ذوي المستوى التعليمي المتدني وعلى أربعة من أبعاد المقياس: بعد العلاج , بعد التقيد الاجتماعي, بعد النظرة الإنسانية, بعد التفاعل الاجتماعي .
كما أشارت النتائج إلى وجحود اثر ذي دلالة لمتغير كون الفرد من ذوي أو من غير ذوي مريض نفسي على الاتجاه نحو المرض النفسي حيث وجد أن هناك فروقا تعزى لصالح أفراد غير ذوي المريض النفسي على ثلاثة أبعاد : بعد العلاج , بعد التقييد الاجتماعي , وبعد النظرة الإنسانية, في حين أظهرت النتائج أن هناك فروقا تعزى لصالح أفراد ذوي المريض النفسي وعلى بعد التفاعل الاجتماعي فقط .
أما بخصوص متغير نوع المرض النفسي فقد أشارت النتائج إلى أن اتجاهات أفراد ذوي المريض العصابي كانت أكثر ايجابية من اتجاهات أفراد ذوي المريض الذهاني وعلى بعدين هما البعد التقييد الاجتماعي وبعد النظرة الإنسانية ..
Destabilizing Attack and Robust Defense for Inverter-Based Microgrids by Adversarial Deep Reinforcement Learning
Authors: Wang Yu , Pal Bikash 
Published: April 2023

<p>The droop controllers of inverter-based resources (IBRs) can be adjustable by grid operators to facilitate regulation services. Considering the increasing integration of IBRs at power distribution level systems like microgrids, cyber security is becoming a major concern. This paper investigates the data-driven destabilizing attack and robust defense strategy based on adversarial deep reinforcement learning for inverter-based microgrids. Firstly, the full-order high-fidelity model and reduced-order small-signal model of typical inverter-based microgrids are recapitulated. Then the destabilizing attack on the droop control gains is analyzed, which reveals its impact on system small-signal stability. Finally, the attack and defense problems are formulated as Markov decision process (MDP) and adversarial MDP (AMDP). The problems are solved by twin delayed deep deterministic policy gradient (TD3) algorithm to find the least effort attack path of the system and obtain the corresponding robust defense strategy. The simulation studies are conducted in an inverter-based microgrid system with 4 IBRs and IEEE 123-bus system with 10 IBRs to evaluate the proposed method. <br>
</p>
Training Postural Balance Control with Pelvic Force Field at the Boundary of Instability
Authors: Omofuma Isirame , Santamaria Victor , Ai Xupeng , Agrawal Sunil 
Published: April 2023

<p>This articles discusses the use of the Robotic Upright Stand Trainer (RobUST), a cable driven exoskeleton that actuates the trunk and pelvis independently, for postural balance control training. It examines the changes that occur in healthy patients after a perturbation based balance training session conducted in virtual reality. In addition, there are two testing conditions tested. In one condition subjects are given assistive support at the pelvis by RobUST to help resist perturbations and in the other, there is no assistive support. Data collected include electromyographic data from lower limb muscles, movement and variability of movement data. </p>
New distance for any finite sets, half the Hamming distance
Authors: Abdurakhmanov Jamolidin 
Published: April 2023

<p> In this paper, we introduce a new, previously unknown, distance (i.e., a new metric) in a set whose elements are some other (any) <em><strong>finite</strong></em> sets. It is proved that with such a metric the set under consideration is a metric space. A direct relationship is established between this distance and the Hamming distance: it is exactly two times smaller than the Hamming distance and it is much easier to calculate it. As an application, the set of natural numbers is considered as a discrete metric space with a new metric introduced, and a new <em><strong>metric</strong></em> criterion for the primality of a natural number is established. <em><strong>This is the first metric criterion in the history of mathematics for a natural number to be prime.</strong></em> </p>
Investigation of EEG Neurophysiological Relationship to TMS Response in Mild Traumatic Brain Injury Patients
Authors: Hussain Mishal , Lewis Connor , Jamil Asif , Franke Laura , Hadimani Ravi 
Published: April 2023

<p>Transcranial magnetic stimulation (TMS) is utilized as a treatment method for a variety of neurological and psychiatric disorders. The standard dose parameter for administration of TMS is known as the resting motor threshold (RMT). Between individuals, the RMT has traditionally been thought to reflect differences in neuroanatomy; however, the functional state of the brain has also been shown to have an influence on this value. In this study, 19 mild traumatic brain injury participants (mTBI) resting state electroencephalography (EEG) was obtained before undergoing TMS treatment. Various time frequency and power spectra values were derived from this EEG data to examine the relationship between RMT and neurophysiology. These EEG connectivity metrics were then used to establish relationships with RMT alone and accounting for differences in individual neuroanatomy. We found that the incorporation of EEG functional connectivity improved multiple regression model predictions of inter-participant RMT variability than neuroanatomy alone. Future investigations into the evaluation of EEG in predicting RMT variability should include a larger participant population with a healthy control. </p>
Field Scattering Analysis of Cylindrical Spatially Dispersive Metasurfaces
Authors: dugan jordan , Nizer Rahmeier João , Smy Tom , Gupta Shulabh 
Published: April 2023

<p>A semi-analytical technique to simulate spatially dispersive (SD) cylindrical metasurfaces is proposed and demon- strated. This method is based on the well-known Eigenfunction Expansion (EFE) method and extends the work of [1], [2] by integrating the Extended GSTCs into this pre-existing method specific to cylindrical surfaces. This method is then applied to several cylindrical metasurfaces composed of spatially dispersive wire dipole unit cells, and successfully verified against commercial full-wave simulations. Finally, using a case of a closed metasur- face shell, the usefulness of the proposed EFE-SD method is shown to illustrate the effect of metasurface thickness on the scattered fields inside and outside the shell. </p>