bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex differences in children operated with pyeloplasty for pelvoureteric junction obstruction
Authors: Högberg Linnea , Värelä Sanni , Anderberg Magnus , Salö Martin 
Published: September 2023

Abstract
Purpose
Pelvoureteric junction obstruction (UPJO) is a common cause of hydronephrosis in children but no previous studies have evaluated differences between boys and girls operated with pyeloplasty. This study aimed to evaluate potential differences between sexes in children operated with pyeloplasty for PUJO in terms of presentation, surgery, and long-term results.

Methods
Data was retrospectively collected from all children operated on with pyeloplasty between January 2002 and December 2020. Data contained several variables covering presentation, surgery, and long-term results.

Results
In total, 194 patients were included of which 126 (64.9%) were boys. There were no significant differences in prenatal findings, pelvic dilation on ultrasound, function of the affected kidney, surgical method, obstruction type, resolution of hydronephrosis, or improvement of function. Boys presented with pain more often than girls (47.4 vs 25.0%, p < 0.01) while girls were more prone to infections preoperatively (17.2 vs 7.0%, p = 0.04). All nine patients requiring reoperation were boys (p = 0.03).

Conclusion
Girls with UPJO seem to experience infections as presenting symptoms more often than boys, while boys significantly more often present with pain. There is also a higher percentage of boys needing reoperation.
Updated Austrian treatment algorithm for metastatic triple-negative breast cancer
Authors: Bartsch Rupert , Rinnerthaler Gabriel , Petru Edgar , Egle Daniel , Gnant Michael , Balic Marija , Sliwa Thamer , Singer Christian 
Published: September 2023

SummaryApproximately 15% of newly diagnosed breast cancer patients have neither hormone receptors expression nor HER2 overexpression and/or HER2/neu gene amplification. This subtype of breast cancer is known as Triple Negative Breast Cancer (TNBC), and carries a significantly elevated risk of local and distant recurrence. In comparison with other breast cancer subtypes, there is a higher rate of visceral and brain metastases. The majority of metastases of TNBC are diagnosed within three years after initial breast cancer diagnosis. While there have been major advances in hormone-receptor- positive and in human epidermal growth factor receptor 2 (HER2)-positive disease over the past two decades, only limited improvements in outcomes for patients with triple negative breast cancer (TNBC) have been observed. A group of Austrian breast cancer specialists therefore convened an expert meeting to establish a comprehensive clinical risk-benefit profile of available mTNBC therapies and discuss the role sacituzumab govitecan may play in the treatment algorithm of the triple-negative breast cancer patients.
Differential trends in prolonged sitting time in Europe: a multilevel analysis of European Eurobarometer data from 2013 to 2022
Authors: Beller Johannes , Graßhoff Julia , Safieddine Batoul 
Published: September 2023

Abstract
Aim
Sitting time is a modifiable risk factor for morbidity and mortality. However, only a few studies have examined how prolonged sitting time has changed over time. Thus, we examined time trends in prolonged sitting time and how trends differ according to sociodemographic groups (age, gender, region, education, income, occupation).

Subject and methods
We used data from three population-based Eurobarometer surveys conducted in 2013, 2017 and 2022, comprising responses from N = 73448 participants aged 15 years and older from 26 European countries. Multilevel logistic regression models were applied.

Results
We found differential trends in the odds of prolonged sitting time over the study period. Sitting time significantly increased among middle-aged participants (21-65 years; OR = 1.14, 95%-CI = [1.07; 1.22]), decreased among adolescents (15-20 years; OR = 0.74, 95%-CI = [0.62; 0.88]), and remained relatively stable for older adults (66+ years; OR = 0.94, 95%-CI = [0.84; 1.06]). Furthermore, the increases in middle-aged adults were most strongly observed in those with manual jobs (OR = 1.36, 95%-CI = [1.16; 1.60]) those unemployed (OR = 2.36, 95%-CI = [1.92; 2.89]), and those with income difficulties (e.g., OR = 1.72, 95%-CI = [1.40; 2.11]).

Conclusion
Thus, trends in sitting time in Europe are differential and not homogeneous: Prolonged sitting time has decreased or remained stable in some subgroups and increased in others. Especially middle-aged participants with a lower socioeconomic status showed increasing prolonged sitting times over the study period. Tailored interventions are needed to target most at-risk groups.
Evaluation of an artificial intelligence-based system for echocardiographic estimation of right atrial pressure
Authors: Zamzmi Ghada , Hsu Li-Yueh , Rajaraman Sivaramakrishnan , Li Wen , Sachdev Vandana , Antani Sameer 
Published: September 2023

AbstractCurrent noninvasive estimation of right atrial pressure (RAP) by inferior vena cava (IVC) measurement during echocardiography may have significant inter-rater variability due to different levels of observers’ experience. Therefore, there is a need to develop new approaches to decrease the variability of IVC analysis and RAP estimation. This study aims to develop a fully automated artificial intelligence (AI)-based system for automated IVC analysis and RAP estimation. We presented a multi-stage AI system to identify the IVC view, select good quality images, delineate the IVC region and quantify its thickness, enabling temporal tracking of its diameter and collapsibility changes. The automated system was trained and tested on expert manual IVC and RAP reference measurements obtained from 255 patients during routine clinical workflow. The performance was evaluated using Pearson correlation and Bland-Altman analysis for IVC values, as well as macro accuracy and chi-square test for RAP values. Our results show an excellent agreement (r=0.96) between automatically computed versus manually measured IVC values, and Bland-Altman analysis showed a small bias of $$-$$
-
0.33 mm. Further, there is an excellent agreement ($$(p<0.01$$

(
p
<
0.01

) between automatically estimated versus manually derived RAP values with a macro accuracy of 0.85. The proposed AI-based system accurately quantified IVC diameter, collapsibility index, both are used for RAP estimation. This automated system could serve as a paradigm to perform IVC analysis in routine echocardiography and support various cardiac diagnostic applications.
Food insecurity and kidney disease: a systematic review
Authors: Ferrara Francesca , Siligato Rossella , Di Maria Alessio , Scichilone Laura , Di Simone Emanuele , Bondanelli Marta , Storari Alda , De Giorgi Alfredo , Di Muzio Marco , Fabbian Fabio 
Published: September 2023

Abstract
Background
The risk of developing and worsening chronic kidney disease (CKD) is associated with unhealthy dietary patterns. Food insecurity is defined by a limited or uncertain availability of nutritionally adequate and safe food; it is also associated with several chronic medical conditions. The aim of this systematic review is to investigate the current knowledge about the relationship between food insecurity and renal disease.

Methods
We selected the pertinent publications by searching on the PubMed, Scopus, and the Web of Science databases, without any temporal limitations being imposed. The searching and selecting processes were carried out through pinpointed inclusion and exclusion criteria and in accordance with the Prisma statement.

Results
Out of the 26,548 items that were first identified, only 9 studies were included in the systemic review. Eight out of the nine investigations were conducted in the US, and one was conducted in Iran. The studies evaluated the relationship between food insecurity and (i) kidney disease in children, (ii) kidney stones, (iii) CKD, (iv) cardiorenal syndrome, and (v) end stage renal disease (ESRD). In total, the different research groups enrolled 49,533 subjects, and food insecurity was reported to be a risk factor for hospitalization, kidney stones, CKD, ESRD, and mortality.

Conclusions
The relationship between food insecurity and renal disease has been underestimated. Food insecurity is a serious risk factor for health problems in both wealthy and poor populations; however, the true prevalence of the condition is unknown. Healthcare professionals need to take action to prevent the dramatic effect of food insecurity on CKD and on other chronic clinical conditions.
Justification and Motivation
Authors: Edwards James 
Published: September 2023

AbstractAccording to the motivational thesis (MT), we are justified in performing an action if and only if we perform that action for the right reason(s). Proponents of MT disagree about how it is best interpreted—about what count as reasons of the right kind. In Fundamentals of Criminal Law, Andrew Simester criticises an interpretation offered by John Gardner. Here, I explore some of Simester's reasons for objecting to that interpretation, and I argue—partly on the basis of those same reasons—that Simester's own interpretation of MT should be revised. I conclude with a preliminary defence of an alternative interpretation, which I call the tripartite view of justification.
Parametric configuration and programming of flexible robotic cells producing biotechnology experiments
Authors: Angelidou Charikleia , Benardos Panorios , Vosniakos George-Christopher 
Published: September 2023

AbstractIn the last decades there has been an ever-increasing trend of accelerated scientific research in the biotechnology sector and the COVID-19 pandemic has further emphasized the need for high-throughput yet flexible processes. Even though automation has gained significant popularity to deal with this problem, the focus has been placed at laboratory level and for specific type of processes only. The aim of these automation applications is to offset the increasing costs of clinical trials, automate tedious laboratory work, run experiments in parallel and make scientific testing efficient and programmable. This paper investigates the application of robotic systems at a larger scale that will allow the automated execution of even custom defined biotechnology experiments so that these can be offered as a service to any interested stakeholder. A digital model of the proposed robotic biotechnology workcell is developed and the necessary methodology is investigated to showcase the feasibility of this approach. The goal is to use the digital model for evaluating different design considerations, such as equipment layout and robot types, as well as for planning and simulating the robot operation under various offline programming strategies. To achieve this goal, the Damped Least Squares Method is used for inverse kinematics control and a robotic arm trajectory planner is developed parametrically using characteristic intermediate points so as to create a motion plan that can be used for any robotic manipulator and any experiment within a family of facility setups. Two experiments are simulated using a SCARA robot and an articulated arm robot, each with an alternative cell layout to show the flexibility and robustness of the proposed approach. The obtained results show that the trajectory planner can consistently generate appropriate motion plans.
Synthesis of Mg–K-biochar bimetallic catalyst and its evaluation of glucose isomerization
Authors: Kang Xiheng , You Zi , Peng Jian , Ragauskas Arthur J. , Pang Jingdong , Zhao Peitao , Yin Yongjun , Song Xueping 
Published: September 2023

AbstractHighly efficient isomerization of glucose to fructose is essential for valorizing cellulose fraction of biomass to value-added chemicals. This work provided an innovative method for preparing Mg-biochar and Mg–K-biochar catalysts by impregnating either MgCl2 alone or in combination with different K compounds (Ding et al. in Bioresour Technol 341:125835, 2021, https://doi.org/10.1016/j.biortech.2021.125835 and KHCO3) on cellulose-derived biochar, followed by hydrothermal carbonization and pyrolysis. Single active substance MgO existing in the 10Mg–C could give better catalytic effect on glucose isomerization than the synergy of MgO and KCl crystalline material present in 10Mg–KCl–C. But the catalytic effect of 10Mg–C was decreased when the basic site of MgO was overloaded. Compared to other carbon-based metal catalysts, 10Mg–KHCO3–C with 10 wt% MgCl2 loading had excellent catalytic performance, which gave a higher fructose yield (36.7%) and selectivity (74.54%), and catalyzed excellent glucose conversion (53.99%) at 100 °C in 30 min. Scanning electron microscope–energy dispersive spectrometer and X-Ray diffraction revealed that the distribution of Mg2+ and K+ in 10Mg–KHCO3–C was uniform and the catalytic active substances (MgO, KCl and K2CO3) were more than 10Mg–C (only MgO). The synergy effects of MgO and K2CO3 active sites enhanced the pH of reaction system and induced H2O ionization to form considerable OH− ions, thus easily realizing a deprotonation of glucose and effectively catalyzing the isomerization of glucose. In this study, we developed a highly efficient Mg–K-biochar bimetallic catalyst for glucose isomerization and provided an efficient method for cellulose valorization.
Graphical Abstract
Higher education and social responsibility: a proposal for internationalization of university—community engagements; perspectives from Uganda
Authors: Amutuhaire Tibelius 
Published: September 2023

AbstractOne of the traditional missions for universities was community service which was updated to entail community engagement. Community engagement is a component of the internationalization of higher education which aspires to improve service delivery within society. Though universities in Uganda have always engaged with communities, they have always done so disregarding the international dimension of higher education. Simultaneously, contemporary approaches to internationalization are primarily concerned with scholarly debate and discussion of societal challenges. However, merging internationalization with community engagement would better serve local and global communities. This is now more relevant considering global challenges such as COVID-19, terrorism, and climate change. Universities should now work more closely with communities to enrich scholarship, contribute to public good aims, and address the current critical social issues. Therefore, university–community engagement should go beyond institutional and disciplinary boundaries that restrict possibilities for fruitful engagement with local and global communities in today’s rapidly changing world. This paper explores the international dimension of community engagement in Uganda’s universities. Using a narrative literature review, the paper highlights how to merge internationalization with community engagement without reproducing inequalities but emphasizing fairness and social justice. The paper holds that community engagement should be integrated into the broader internationalization agenda of universities for better service delivery.
Anti-Corruption in a Party-State: Constitutional Implications of China's Supervisory Reform
Authors: Lee James WC 
Published: September 2023

AbstractThe 2018 amendments to the People's Republic of China (PRC) Constitution saw the establishment of a system of supervisory commissions, which is a landmark development not only for anti-corruption, but also constitutional law in China. After providing an overview of the background and legal framework of the reform, this article discusses its constitutional implications from three perspectives. First, the reform alters the long-established state structure and creates interesting dynamics of institutional interactions among various branches of state structure. Second, it marks a reversal from the principle of ‘party-state separation’ and raises difficult issues of interface and transition between the party disciplinary system and the formal legal system. Finally, it legalises the previously extralegal practice of shuanggui (‘double specifications’) and affects the individual rights of those subject to investigation. The article concludes with some brief reflections on what this development indicates for the future of the rule of law in China, and highlights the potential for further research.
Psychiatric sequelae after SARS-Cov-2 infection: trajectory, predictors and associations in a longitudinal Australian cohort
Authors: Dodd Seetal , Mohebbi Mohammedreza , O’Donohue Josie , Matthews Gail , Darley David R. , Berk Michael 
Published: September 2023

AbstractA relationship between SARS-CoV-2 infection and psychiatric symptoms has been identified but is still being fully investigated. Neuropsychiatric sequalae have been reported for several infectious agents and are not unexpected for SARS-CoV-2 infection. This study follows for 12 months a sample (N = 144) of people who have had a confirmed infection of SARS-CoV-2. Medical and neuropsychiatric data and biological specimens are collected at 6 study visits. The 34-item SPHERE questionnaire, the Depression in the Medically Ill instrument, the EQ-5D-5L quality of life instrument and the visual analogue scale of fatigue were administered at multiple timepoints and associations with measures of illness and inflammatory biomarkers were investigated using the generalised estimating equation. Associations between inflammatory biomarkers and mental health measures of various effect sizes were identified. A robust inverse association was found between mental health outcomes and long covid status, but not between mental health outcomes and covid illness severity. This study suggests that long covid may be the strongest predictor of neuropsychiatric symptoms amongst people who have been infected with SARS-CoV-2.
The Pluralization of Scripture in Early American Protestantism: Competing Bible Translations and the Debate over Universal Salvation, ca. 1700–1780
Authors: Stievermann Jan , Pietrenka Benjamin 
Published: September 2023

ABSRACTThis article addresses a pervasive historiographic assumption about the supremacy of the King James Bible in British North America by proposing that a process we call the “pluralization of Scriptures” forced colonial Protestants to square their belief in “the Bible” with the undeniable reality of many “bibles.” While the KJV remained dominant among anglophone Protestant populations, by the early eighteenth century some heirs of New England Puritanism were challenging its adequacy and pushing for improved translations of key passages, as members of the clerical intelligentsia became immersed in cutting-edge textual and historical scholarship. Also, during the eighteenth century, non-English cultures of biblicism with their own religious print markets formed in the middle colonies, most importantly among diasporic communities of German Protestants, who brought the Luther Bible to America, and diverse “heterodox” Bibles associated with radical Pietist groups. This essay contends that, well before the American Revolution, the advent of Higher Criticism in American seminaries, and the first wave of English-language Bible production in the early republic, Scripture had ceased to be a static, monolithic entity. A considerable number of alternative translations and commentary traditions in a variety of different languages came to co-exist and, at some points, also interact with each other. Moreover, we argue that competing translations, even of passages speaking to core Christian doctrines, were inextricably bound up with some of the most significant controversies among colonial Protestants, such as the debate over the doctrine of universal salvation, our main case study.
Multi-cell trap developments towards the accumulation and confinement of large quantities of positrons
Authors: Singer M. , Danielson J.R. , König S. , Pedersen T. Sunn , Schweikhard L. , Stenson E.V. 
Published: September 2023

The multi-cell Penning–Malmberg trap concept has been proposed as a way to accumulate and confine unprecedented numbers of antiparticles, an attractive but challenging goal. We report on the commissioning and first results (using electron plasmas) of the World's second prototype of such a trap, which builds and improves on the findings of its predecessor. Reliable alignment of both ‘master’ and ‘storage’ cells with the axial magnetic field has enabled confinement of plasmas, without use of the ‘rotating wall’ (RW) compression technique, for over an hour in the master cell and tens of seconds in the storage cells. In the master cell, attachment to background neutrals is found to be the main source of charge loss, with an overall charge-confinement time of 8.6 h. Transfer to on-axis and off-axis storage cells has been demonstrated, with an off-axis transfer rate of$50\,\%$of the initial particles, and confinement times in the storage cells in the tens of seconds (again, without RW compression). This, in turn, has enabled the first simultaneous plasma confinement in two off-axis cells, a milestone for the multi-cell trap concept.
Documenting the microbiome diversity and distribution in selected fleas from South Africa with an emphasis on the cat flea, Ctenocephalides f. felis.
Authors: Matthee Conrad A. , Bierman Anandi , Krasnov Boris R. , Matthee Sonja , van der Mescht Luther 
Published: September 2023

AbstractThe factors that influence parasite associated bacterial microbial diversity and the geographic distributions of bacteria are not fully understood. In an effort to gain a deeper understanding of the relationship between the bacterial diversity of Ctenocephalides fleas and host species and the external environment, we conducted a metagenetic analysis of 107 flea samples collected from 8 distinct sampling sites in South Africa. Pooled DNA samples mostly comprising of 2 or 3 individuals sampled from the same host, and belonging to the same genetic cluster, were sequenced using the Ion PGM™ Hi-Q™ Kit and the Ion 316™ Chip v2. Differences were detected in the microbiome compositions between Ctenocephalides felis, Ctenocephalides canis and Ctenocephalides connatus. Although based on a small sample, C. connatus occurring on wildlife harboured a higher bacterial richness when compared to C. felis on domestic animals. Intraspecific differences in the microbial OTU diversity were detected within C. f. felis that occurred on domestic cats and dogs. Different genetic lineages of C. f. felis were similar in microbial compositions but some differences exist in the presence or absence of rare bacteria. Rickettsia and Bartonella OTU's identified in South African cat fleas differ from those identified in the USA and Australia. Intraspecific microbial compositions also differ across geographic sampling sites. Generalized dissimilarity modelling showed that temperature and humidity are potentially important environmental factors explaining the pattern obtained.