bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vanadium Oxide‐Doped Laser‐Induced Graphene Multi‐Parameter Sensor to Decouple Soil Nitrogen Loss and Temperature
Authors: Yang Li , Yan Jiayi , Meng Chuizhou , Dutta Ankan , Chen Xue , Xue Ye , Niu Guangyu , Wang Ya , Du Shuaijie , Zhou Peng , Zhang Cheng , Guo Shijie , Cheng Huanyu 
Published: January 2023

AbstractMonitoring nitrogen utilization efficiency and soil temperature in agricultural systems for timely intervention is essential for crop health with reduced environmental pollution. Herein, this work presents a high‐performance multi‐parameter sensor based on vanadium oxide (VOX)‐doped laser‐induced graphene (LIG) foam to completely decouple nitrogen oxides (NOX) and temperature. The highly porous 3D VOX‐doped LIG foam composite is readily obtained by laser scribing vanadium sulfide (V5S8)‐doped block copolymer and phenolic resin self‐assembled films. The heterojunction formed at the LIG/VOX interface provides the sensor with enhanced response to NOX and an ultralow limit of detection of 3 ppb (theoretical estimate of 451 ppt) at room temperature. The sensor also exhibits a wide detection range, fast response/recovery, good selectivity, and stability over 16 days. Meanwhile, the sensor can accurately detect temperature over a wide linear range of 10–110 °C. The encapsulation of the sensor with a soft membrane further allows for temperature sensing without being affected by NOX. The unencapsulated sensor operated at elevated temperature removes the influences of relative humidity and temperature variations for accurate NOX measurements. The capability to decouple nitrogen loss and soil temperature paves the way for the development of future multimodal decoupled electronics for precision agriculture and health monitoring.
Scheduling doesn't matter! A noninferiority study of block versus longitudinal scheduling for emergency medicine resident pediatric procedural training experience
Authors: Reynolds Maegan S. , Lo Charmaine , Shi Junxin , Mitzman Jennifer 
Published: January 2023

AbstractBackgroundEmergency medicine (EM) residencies offer a wide variety of scheduling models for pediatric patient experience, including blocked weeks in pediatric emergency departments and longitudinal models with pediatric emergency pod/department shifts integrated within other clinical experiences. Concerns with autonomy, attending entrustment, and resident comfort imply that these different scheduling models may impact EM residents' pediatric procedure volumes. The purpose of this study is to quantitatively compare EM residents' pediatric procedure experience and volumes between block versus longitudinal scheduling models. We hypothesize noninferiority between the scheduling models.MethodsA retrospective review characterized the numbers and types of procedures performed by The Ohio State Emergency Medicine residents at the tertiary care pediatric hospital where residents' receive their pediatric emergency medicine clinical experience. Procedure numbers and variety were compared across six academic years: four with a block model, one reorganization year, and one integrated longitudinal year.Results2552 procedures were performed by 266 resident academic years over the 6‐year period. Overall, no statistically significant differences in the number of procedures performed per year or the variety of types of procedures performed per year were found when comparing the block and longitudinal models. Differences were seen in experience of PGY1 versus PGY3 residents between scheduling models and the overall experience and volumes of the PGY2 residents during the reorganization year.ConclusionsOur study quantitatively concluded that the longitudinal scheduling model is noninferior to the more traditional block scheduling model for emergency medicine residents' pediatric emergency medicine clinical experience when reviewing volumes and types of procedures performed in a pediatric emergency department. This suggests that procedural opportunities do not need to dictate scheduling models.
Oncological outcomes of Crohn's disease‐associated cancers focusing on disease behavior
Authors: Yamamoto Akira , Toiyama Yuji , Ikeuchi Hiroki , Uchino Motoi , Futami Kitaro , Okamoto Kinya , Ogino Takayuki , Ishihara Soichiro , Ajioka Yoichi , Sugihara Kenichi ,   for the Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers by the Japanese Society for Cancer of the Colon and Rectum
Published: January 2023

AbstractBackgroundThe overall risk of colorectal cancer in Crohn's disease (CD) is higher than in the general population, and CD‐associated cancer (CDAC) has poorer prognosis than sporadic cancer. Developing treatment strategies for improving the prognosis of CDAC, we evaluated the characteristics of CDAC according to the underlying disease behavior, namely stricturing and penetrating.MethodsThis multicenter retrospective study comprises 316 CDAC patients who underwent surgery between 1985 and 2019. Clinicopathological findings including disease behavior and oncological outcomes were investigated.ResultsThere was no association between the preoperative course of CDAC patients and disease behavior; however, postoperative information revealed distinctly different characteristics between CDAC patients with stricturing behavior and those with penetrating behavior (stricturing with lymphatic invasion and peritoneal dissemination recurrence, and penetrating with histologically poorly differentiated and local recurrence). Oncological outcome of patients with CDAC was distinctly different according to disease behavior, as penetrating provided a poor outcome (overall survival [OS]: p = 0.02; relapse‐free survival [RFS]: p = 0.002) whereas stricturing had no effect. Furthermore, penetrating behavior was identified as one of the independent risk factors for poor OS and RFS (OS: hazard ratio [HR] 1.89, 95% confidence interval [CI] 1.16–3.09, p = 0.01; RFS: HR 2.15, 95% CI 1.28–3.63, p = 0.004).ConclusionsOur study highlights the different characteristics of CDAC according to the underlying disease behavior and substantiates the poor prognosis of CDAC patients with penetrating behavior. Treatment planning including screening, surgical procedures, and postoperative treatment, with awareness of these findings, may contribute to improved prognosis for CDAC patients.
Experimental and numerical studies of interaction between liquid droplets with hot surfaces under different conditions
Authors: Guchhait Subhasish , Kumar Pratim 
Published: January 2023

AbstractIn the present paper, experimental and numerical studies for the interaction studies between different liquid droplets and hot metal surfaces were carried out. The obtained results were interpreted using graphs and figures. Droplet impact, spreading, breakup and Leidenfrost phenomenon were observed with the help of a video camera at 100 fps. The interaction studies were done at different surface temperatures and different droplet‐impinging velocities. Three metals and three liquids were selected for the present study. Copper, aluminium and steel were selected as metals with varying roughness factors maintained at different temperatures. At the same time, in liquid entities, methanol, ethanol and kerosene were selected along with water in some portions. The selections of the metals were based on the thermal diffusivity property as it influences the thermal interaction between the droplet and the hot metal surface. The temperature range of the metal surface was kept from 150°C to 425°C, and the impinging velocity range of droplets was in the field of 2.4–4.9 m/s. For computational studies, the Ansys Fluent R3‐2019 version was used. Numerical analysis for the interaction process was carried out using the volume of fluid (VOF) method, solving Navier–Stokes and energy equations in a 2D‐geometry transient simulation. Parameters like surface temperature, heat flux and spreading ratio w.r.t. change in Weber number were investigated and presented in the present paper. Obtained results are useful for better understanding of droplet physics while interacting with hot surfaces which further helps in development of new methods for effective spray system designs. Results show that for a lower value of Weber number, the droplets spread less as compare to high Weber number. Also, spreading ratio of droplets depends only on the surface roughness.
The effect of electroacupuncture at ST25 on Parkinson's disease constipation through regulation of autophagy in the enteric nervous system
Authors: Song Li‐Zhe‐Xiong , Xu Na , Yu Zhi , Yang Hui , Xu Cheng‐cheng , Qiu Zi , Dai Jing‐wen , Xu Bin , Hu Xuan‐ming 
Published: January 2023

AbstractThe effectiveness and safety of electroacupuncture (EA) for constipation have been confirmed by numerous clinical studies and experiments, and there are also studies on the efficacy of EA for Parkinson's disease (PD) motor symptoms. However, there are few researches on EA for PD constipation. Autophagy is thought to be involved in the mechanistic process of EA in the central nervous system (CNS) intervention in Parkinson's pathology. However, whether it has the same effect on the enteric nervous system (ENS) has not been elucidated. Therefore, we investigated whether EA at Tianshu (ST25) acupoint promotes the clearance of α‐Syn and damaged mitochondria aggregated in the ENS in a model of rotenone‐induced PD constipation. This study evaluated constipation symptoms by stool characteristics, excretion volume, and water content, and the expression levels of colonic ATG5, LC3II, and Parkin were detected by Western Blot (WB) and Real‐Time Quantitative PCR (RT‐qPCR). The relationship between the location of α‐Syn and Parkin in the colonic ENS was observed by immunofluorescence (IF). The results showed that EA intervention significantly relieved the symptoms of rotenone‐induced constipation in PD rats, reversed the rotenone‐induced down‐regulation of colonic ATG5, LC3II, and Parkin expression, and the positional relationship between colonic α‐Syn and Parkin proved to be highly correlated. It is suggested that EA might be helpful in treating PD constipation by modulating Parkin‐induced mitochondrial autophagy.
Improvement in Disease Activity in Refractory Juvenile Dermatomyositis Following Abatacept Therapy
Authors: Curiel Rodolfo V. , Nguyen William , Mamyrova Gulnara , Jones Derek , Ehrlich Alison , Brindle Kathleen A. , Haji‐Momenian Shahriar , Sheets Robert , Kim Hanna , Jones Olcay Y. , Rider Lisa G. ,   the Abatacept in Dermatomyositis (AID) Trial Investigators
Published: January 2023

ObjectiveThis open‐label, 24‐week study was conducted to evaluate the safety and efficacy of abatacept in patients with refractory juvenile dermatomyositis (DM).MethodsTen patients ≥7 years of age with moderate disease activity were enrolled in a 24‐week study to examine the safety of subcutaneous abatacept and patient responses to the treatment. The primary endpoint was the International Myositis Assessment and Clinical Studies (IMACS) group Definition Of Improvement (DOI). Secondary endpoints included safety, changes in the core set activity measures (CSMs) of the IMACS group and the Pediatric Rheumatology International Trials Organization, and improvements in disease activity based on the American College of Rheumatology (ACR)/EULAR response criteria for juvenile DM. Radiologists blinded with regard to participant data assessed magnetic resonance images (MRIs) of patient thigh muscles. Interferon (IFN)–regulated gene score was performed on whole‐blood RNA samples using a NanoString assay, and cytokines were assessed using a Luminex assay.ResultsFive patients achieved DOI at week 12, and 9 patients achieved DOI at week 24, including 2 patients with minimal, 4 patients with moderate, and 3 patients with major improvement by the 2016 ACR/EULAR response criteria for juvenile DM when patients were assessed using the CSMs of the IMACS Group. Improvements from baseline were seen in all CSMs at weeks 12 and 24, except in muscle enzymes. Daily glucocorticoid doses decreased from a mean of 16.7 mg at baseline to 10.2 mg at week 24 (P = 0.002). Average MRI muscle edema scores decreased from a mean baseline score of 5.3 to 2.3 at week 24 (P = 0.01). Six patients had down‐trending IFN‐regulated gene scores and galectin‐9 expression at week 24. Decreases in IFN‐regulated gene scores and in levels of interferon‐γ‐inducible protein 10kDa, galectin‐9, and interleukin‐2 correlated with improvements in disease activity and in muscle edema shown on MRI. Eleven grade 2 or 3 treatment‐emergent adverse events were observed.ConclusionThis open‐label study demonstrated that abatacept may be beneficial for patients with treatment‐refractory juvenile DM.image
Cost‐effectiveness of first‐line immunotherapies for advanced non‐small cell lung cancer
Authors: Yang Szu‐Chun , Ou Huang‐Tz , Su Wu‐Chou , Wang Shi‐Yi 
Published: January 2023

AbstractBackgroundResearchers have not simultaneously compared the cost‐effectiveness of six immunotherapies with chemotherapy for advanced non‐small cell lung cancer. This study evaluated the cost‐effectiveness across different programmed death‐ligand 1 (PD‐L1) levels.MethodsA Markov model with lifetime horizon was created for seven regimens: pembrolizumab plus chemotherapy (pembro‐chemo), nivolumab plus ipilimumab (nivo‐ipi), nivolumab, ipilimumab plus chemotherapy (nivo‐ipi‐chemo), atezolizumab plus chemotherapy (atezo‐chemo), atezolizumab, bevacizumab plus chemotherapy (atezo‐beva‐chemo), single‐agent pembrolizumab, and chemotherapy alone. Input parameters were derived from trial data, a network meta‐analysis, and other literature. We conducted the analysis from the perspective of US health care sector.ResultsFor all patients without considering PD‐L1 expression, the incremental cost‐effectiveness ratio (ICER) of pembro‐chemo versus chemotherapy was $183,299 per quality‐adjusted life year (QALY). The preferred regimens based on ICERs differed by PD‐L1 levels. For patients with PD‐L1 ≥50%, pembrolizumab versus chemotherapy and pembro‐chemo versus pembrolizumab resulted in ICERs of $96,189 and $198,913 per QALY, respectively. The other strategies were dominated. For patients with PD‐L1 of 1%–49%, the ICER of pembro‐chemo comparing to chemotherapy was $218,159 per QALY. The other regimens were dominated by pembro‐chemo. For patients with PD‐L1 <1%, nivo‐ipi versus chemotherapy and nivo‐ipi‐chemo versus nivo‐ipi resulted in ICERs of $161,277 and $881,975 per QALY, and the other regimens were dominated strategies. At the willingness‐to‐pay threshold of $150,000 per QALY, pembrolizumab had 87% and pembro‐chemo had 1% probabilities being cost‐effective in patients with PD‐L1 ≥50% and 1%–49%, respectively. Nivo‐ipi had a 34% probability being cost‐effective in patients with PD‐L1 <1%.ConclusionsThe PD‐L1 level should be incorporated into treatment decision‐making. Our findings suggest that first‐line pembrolizumab, pembro‐chemo, and nivo‐ipi are the preferred strategies for patients with PD‐L1 ≥50%, 1%–49%, and <1%, respectively.
The experience of psychological therapies for people with multiple sclerosis: A mixed‐methods study towards a patient‐centred approach to exploring processes of change
Authors: Fragkiadaki Evangelia , Anagnostopoulos Fotios , Triliva Sofia 
Published: January 2023

AbstractPsychological therapies are effective for managing multiple sclerosis (MS) symptoms such as depression, pain and fatigue. Cognitive behavioural therapy (CBT), mindfulness and other theory‐led approaches have been applied and were found to have moderate effects. The present study adopts a patient‐led approach to investigate people with MS' (PwMS) experiences of psychological therapies and the change processes they identify. In this naturalistic, mixed‐methods design, semistructured interviews were conducted and three questionnaires were administered to 20 PwMS at two different times. Qualitative data collection and analysis followed the interpretative phenomenological analysis (IPA) guidelines, and quantitative data were analysed using paired t tests. Four superordinate themes described the participants' experiences of change as related to their psychological therapy: from despair to relief; from feeling their body as alien to becoming acquainted with an unpredictable new body; from helplessness to empowerment; and from punishment to forgiveness. Quantitative results showed that physical function and general health perception improved, and anxiety was significantly reduced. Despite seeking help from diverse psychological therapy modalities, the analysis revealed common themes that the participants found significant in their therapy stories. Following a patient‐centred approach, the development of psychological therapies for PwMS should focus on their relationships, everyday lives, body perception, losses, shame and guilt. PwMS also need to be understood and acknowledged beyond their condition.
Bifurcation stenting: If the shoe doesn't fit
Authors: Chaus Adib , Uretsky Barry F. 
Published: January 2023

Key Points
The modified TAP procedure (m‐TAP) utilizes indenting a MV non‐compliant balloon with the side branch stent to minimize stent struts in the main vessel.
This novel technique results in larger stent area and a shorter neocarina than traditional TAP.
With the general increase in use of IVUS to improve long‐term outcomes, m‐TAP looks to be a welcome improvement in the TAP approach.
Cadaveric kidney transplantation in an ESRD patient with Klippel–Feil syndrome—A case report
Authors: Dialameh Hossein , Namdari Farshad , Etezadi Farhad , Inanloo Seyed Hassan , Mousavi Seyed Hamid , Rahimzadeh Hormat , Nazarpour Mohammad Javad 
Published: January 2023

AbstractKlippel–Feil syndrome (KFS) is a congenital skeletal disorder with classic clinical triad consisting of short neck, low hairline, and limitation of neck movement. In addition to skeletal deformities, diagnosed cases of KFS may have other anomalies such as cardiac, neurologic, and genitourinary disorder. We report a case of KFS with associated anomalies such as short neck, limitation of neck movement, scoliosis of cervical spine, and dextrocardia who received successful cadaveric kidney transplantation. This article aims to present kidney transplantation as option of treatment in KFS patient with ESRD and emphasize on the difficulty in airway management of this patient.
Facile Electrochemical Preparation of Hydrophobic Antibacterial Fabrics Using Reduced Graphene Oxide/Silver Nanoparticles
Authors: Jafari Behnaz , Lacerda Carla M. R. , Botte Gerardine G. 
Published: January 2023

AbstractA novel facile electrochemical method was developed for in situ coating of fabrics with reduced graphene oxide/silver nanoparticles. The procedure consisted of three steps: spray coating of graphene oxide on the fabric, electrochemical reduction of the graphene oxide layer, and electrodeposition of silver nanoparticles on the fabrics. All the steps were performed at room temperature without using a toxic reducing agent. The fabrics coated with reduced graphene oxide/silver nanoparticles demonstrated excellent hydrophobicity (water contact angle of 148.0°±1.1) and strong antibacterial activity against gram‐negative Escherichia coli bacteria (reduction rate >99.99 %). The durability of the modified fabrics was investigated by a washing experiment. Based on the results of this test, the reduction rate of the fabric did not decrease after 60 washing times. The results of the silver ion release test revealed a slow leaching rate from the fabric which confirms the long‐term antibacterial activity of the fabrics.
CD98 defines a metabolically flexible, proinflammatory subset of low‐density neutrophils in systemic lupus erythematosus
Authors: Martin Katherine R. , Day Jessica A. , Hansen Jacinta A. , D'Silva Damian B. , Wong Huon L. , Garnham Alexandra , Sandow Jarrod J. , Nijagal Brunda , Wilson Nicholas , Wicks Ian P. 
Published: January 2023

AbstractBackgroundLow‐density neutrophils (LDN) are a distinct subset of neutrophils rarely detected in healthy people but appear in the blood of patients with autoimmune diseases, including systemic lupus erythematosus (SLE), and are mobilised in response to granulocyte colony‐stimulating factor (G‐CSF). The aim of this study was to identify novel mechanisms responsible for the pathogenic capacity of LDN in SLE.MethodsNeutrophils were isolated from donors treated with G‐CSF, and whole‐cell proteomic analysis was performed on LDN and normal‐density neutrophils.ResultsCD98 is significantly upregulated in LDN from G‐CSF donors and defines a subset of LDN within the blood of SLE patients. CD98 is a transmembrane protein that dimerises with L‐type amino acid transporters. We show that CD98 is responsible for the increased bioenergetic capacity of LDN. CD98 on LDN mediates the uptake of essential amino acids that are used by mitochondria to produce adenosine triphosphate, especially in the absence of glucose. Inhibition of CD98 reduces the metabolic flexibility of this population, which may limit their pathogenic capacity. CD98+ LDN produce more proinflammatory cytokines and chemokines than their normal density counterparts and are resistant to apoptosis, which may also contribute to tissue inflammation and end organ damage in SLE.ConclusionsCD98 provides a phenotypic marker for LDN that facilitates identification of this population without density‐gradient separation and represents a novel therapeutic target to limit its pathogenic capacity.
Cognitive function and neuroimaging characteristics in patients with childhood‐onset type 1 diabetes mellitus
Authors: He Jing , Zou Wenjing , Zhu Jiang , Du Hongyu , Fan Jie , Li Xia , Zhou Zhiguang , Wang Ruixuan , Zhu Xiongzhao 
Published: January 2023

AbstractAimsIn this study, we used neuropsychological tests and neuroimaging to examine the cognitive functions and neuroimaging characteristics to explore the brain mechanism of cognitive deficits in patients with childhood‐onset type 1 diabetes mellitus (T1DM).Materials and MethodsA total of 30 patients with childhood‐onset T1DM and 28 healthy controls (HC) participated in the study. Neuropsychological tests were used to assess intelligence quotient, memory, and executive function. Voxel‐based morphometry‐diffeomorphic anatomical registration through exponential lie algebra analysis and amplitude of low‐frequent fluctuation (ALFF) were performed to evaluate the brain grey matter volume and neural spontaneous activity for each participant.ResultsCompared with HC, patients with childhood‐onset T1DM showed a significant decline in verbal memory (p = 0.001) and visual memory (p = 0.002). Patients with T1DM had smaller grey matter volumes at the midbrain, thalamus, and cerebellar culmen. They demonstrated an increased ALFF value in the left precentral gyrus, left postcentral gyrus, left insula, and left supramarginal gyrus and a decreased ALFF value in the basal ganglia (putamen nucleus), right insula, right superior temporal gyrus, and cerebellar posterior lobe than the healthy control group. In the T1DM group, the ALFF value in the right insula was positively related to the verbal memory scores (r = 0.423, p = 0.025).ConclusionsChildhood‐onset T1DM was associated with cognitive deficits and changes in brain structure and function. These findings suggest that the brain structural and functional alterations in these regions may be the neuropathology of cognitive deficits in patients with T1DM.