bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of the inclusion of extruded flaxseed in the diet of fattening pigs on lipid metabolism and tissue redox status
Authors: Czech Anna , Klimiuk Kamila , Sembratowicz Iwona 
Published: August 2023

AbstractThe aim of the study was to evaluate the effect of a diet containing extruded flaxseed (Linum usitatissimum L.) on the fatty acid composition of the loin, blood lipid parameters, and the redox status of tissues of finishing pigs. A total of 160 weaners (about 30–110 kg BW) were assigned to four experimental groups of 40 animals each (5 replicates with 8 individuals each). Group C (control) received a diet in which the fat source was soybean oil, while in groups 2FE, 4FE and 6FE soybean meal was replaced with extruded flaxseed in the amount of 2%, 4% or 6%, respectively. The diet containing extruded flaxseed reduced cholesterol levels in the blood plasma of pigs (grower 2FE and 6FE vs. C; finisher 2FE, 4FE and 6FE vs. C) and loin muscle (2FE, 4FE and 6FE vs. C). A decrease in the atherogenic LDL-C fraction and in the content of triacylglycerols was also noted in the blood plasma of grower and finisher pigs receiving flaxseed (2FE, 4FE and 6FE vs. C). The beneficial effects noted in the experimental pigs also included an increase in the overall content of n-3 PUFAs, especially ALA (18:3 n-3), and a reduction in the n-6/n-3 ratio. This was especially evident at 4% and 6% inclusion of flaxseed. The highest proportion of flax (6%) in the blend increased lipid peroxidation, as evidenced by the increase in the content of LOOH and MDA in the blood plasma of grower and finisher pigs. For this reason, a 4% share of flaxseed in the diet of fattening pigs seems to be optimal, while higher levels require an additional supply of exogenous antioxidants.
Comparing effects and application of telemedicine for different specialties in emergency medicine using the Emergency Talk Application (U-Sim ETA Trial)
Authors: O’Sullivan Seán , Schneider Henning 
Published: August 2023

AbstractTelemedicine as a technology can support processes in the field of emergency medicine (EM) including therapies and diagnostics, but technically is often based on hardware solutions for local EM structures, especially when involving the field of pre-hospital EM. By developing an open-source, data protection compliant solution (EU GDPR and HIPAA) as well as using standardized web and open-source based technology the Emergency Talk Application (ETA) can be used as a technology that can connect emergency medical providers and include already available regional structures. By actively involving patients and connecting these with emergency or urgent care physicians ETA can be used not only as a teleconsultation system for paramedics and physicians, but in a wider network. Randomised simulation trial, comparing EM scenarios from the field of internal medicine, trauma and neurology. Participants were qualified as certified paramedics or emergency physicians (EP). Paramedics performed as ambulances crews and involved an EP if needed via ETA as Tele-Emergency Physicians (TEP). EP participated from a device of their choice, while being able to stay within their clinical workspace. From 141 scenarios 129 used ETA. Significant differences were found for the length of scenarios, duration of time the TEP was on scene, TEP arrival after scenario start, duration until TEP was called and the duration until a diagnosis was made. Also a strong positive and significant correlation between duration of the scenario and the time a TEP was bound could be described. Telemedicine is a technology that is increasingly used in the field of EM. Improving the use of telemedicine by using up-to date technology while allowing an integration of available technical and human resources is a challenge in the field of emergency medicine especially with its regional but also broad medical variety. When using one technical solution, understanding that different cases need a different medical and also telemedical approach can help in the understanding and improving therapies, diagnostics but also the involved processes and solutions. Such results are not only relevant for healthcare providers but especially by law and decision makers as to which type of solution could be introduced in each regional setting.
Irreversibility analysis through neural networking of the hybrid nanofluid for the solar collector optimization
Authors: Alharbi Sayer Obaid , Gul Taza , Khan Ilyas , Khan Mohd Shakir , Alzahrani Saleh 
Published: August 2023

AbstractAdvanced techniques are used to enhance the efficiency of the energy assets and maximize the appliance efficiency of the main resources. In this view, in this study, the focus is paid to the solar collector to cover thermal radiation through optimization and enhance the performance of the solar panel. Hybrid nanofluids (HNFs) consist of a base liquid glycol (C3H8O2) in which nanoparticles of copper (Cu) and aluminum oxide (Al2O3) are doped as fillers. The flow of the stagnation point is considered in the presence of the Riga plate. The state of the solar thermal system is termed viva stagnation to control the additional heating through the flow variation in the collector loop. The inclusion of entropy generation and Bejan number formation are primarily conceived under the influence of physical parameters for energy optimization. The computational analysis is carried out utilizing the control volume finite element method (CVFEM), and Runge–Kutta 4 (RK-4) methods. (FEATool Multiphysics) software has been used to find the solution through (CVFEM). The results are further validated through a machine learning neural networking procedure, wherein the heat transfer rate is greatly upgraded with a variation of the nanoparticle's volume fraction. We expect this improvement to progress the stability of heat transfer in the solar power system.
Experimental study on high temperature tensile behaviour of aluminium alloy AA5083 with oscillating load
Authors: Shirinzadeh Dastgiri Mohammad , Fuerth Zackary , Kiawi Leo , Green Daniel 
Published: August 2023

AbstractThe flow behaviour of aluminium alloy AA5083 at 450 $$^\circ $$

∘

C has been investigated under quasi-static loading conditions with and without a superimposed oscillating load. Samples were placed under tensile load at constant strain rates ranging from 0.001 to 0.3 s$$^{-1}$$

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1

. A fixture was designed to generate the required sine-wave oscillation and was attached to the MTS tensile test machine along with a secondary, highly sensitive load cell. The frequencies of the imposed oscillations ranged from 5 to 100 Hz with an amplitude ranging from 0.02 to 0.5-N. It was observed that the imposition of oscillations influences the deformation behaviour of the material. Although the yield and tensile strength remain relatively constant, the total elongation is 8–23% higher under an imposed oscillating load. In addition, the thickness distribution profiles along the gauge length of the tensile specimens were investigated and it was observed that in the presence of oscillations the thickness distribution is more uniform. It was concluded that the presence of a superimposed oscillative load will result in greater deformation capabilities before fracture and postpone the occurrence of damage compared to conventional forming. This phenomenon was further explored utilising a user-defined material subroutine developed for the finite element solver LS-DYNA to simulate the conducted constant load tensile tests.
Cardiorespiratory dose comparison among six radiotherapy regimens for patients with left-sided breast cancer
Authors: Lu Yongkai , Ma Yanfang , Yang Di , Li Yi , Yuan Wei , Tang Fengwen , Xu Lei , Zhou Luping , Lin Hao , Li Binglin , Chen Ruijuan , He Chenchen , Zhao Dongli 
Published: August 2023

AbstractThere is uncertainty regarding the benefits and drawbacks of various radiation protocols for the treatment of left-sided breast cancer. To address this issue, we conducted a Bayesian network analysis. First, we searched several electronic databases for eligible literature. Next, we pooled the data from twelve studies concerning three-dimensional conformal radiation therapy (3D-CRT), intensity modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT), combined with either deep inspiratory breath-holding (DIBH) or free-breathing (FB) modalities. The integrated cardiac and pulmonary dosimetric indexes for all included treatments were compared using Bayesian networks. A direct meta-analysis indicated that for the two methods of 3D-CRT and IMRT, DIBH technology was more effective than FB in reducing the radiation dose to the heart and lungs. Additionally, according to the network results, DIBH was superior to FB in all six treatment options, regardless of whether the plan was 3D-CRT, IMRT, or VMAT. Besides, the combined data indicated that the FB-3D-CRT regimen had the weakest dosimetric advantage of all the treatments. Excluding FB-3D-CRT, each of the other five treatments had its own specific benefits. This is the first Bayesian study of several radiotherapy regimens for breast cancer patients on the left side, and the findings can be used to select appropriate radiotherapy programs for breast cancer patients.
Shortening/re-lengthening and nailing versus bone transport for the treatment of segmental femoral bone defects
Authors: Yang Na , Ma Teng , Liu Lu , Xu YiBo , Li Zhong , Zhang Kun , Wang Qian , Huang Qiang 
Published: August 2023

AbstractSegmental femoral bone defects are a severe challenge for orthopedic trauma surgeons. The objective of this study was to compare the efficacy of the shortening/re-lengthening and nailing (SRN) technique with the traditional bone transport (BT) technique in treating patients with such defects. A retrospective study was conducted involving 46 patients with segmental femoral bone defects, with 21 cases treated using the SRN technique (SRN group) and 25 cases managed with the traditional BT technique (BT group). The mean length of the bone defect was 5.8 ± 1.1 cm in the SRN group and 6.1 ± 1.6 cm in the BT group. Various parameters including time in frame, external fixation index, self-rating anxiety scale (SAS) scores, bone healing scores, limb function scores, and complications were recorded. The mean time in frame for the SRN group was 3.7 ± 1.4 months, significantly shorter than the 9.4 ± 3.7 months observed in the BT group (p < 0.05). Furthermore, the mean external fixation index for the SRN group was 0.62 ± 0.12 months/cm, significantly lower than the 1.50 ± 0.19 months/cm observed in the BT group (p < 0.05). There were no significant differences in bone healing scores between the SRN and BT groups (p = 0.237). The SAS scores and incidence of complications were significantly lower in the SRN group compared to the BT group (p < 0.05). Overall, the SRN technique demonstrated superior clinical efficacy compared to the traditional BT technique for the management of segmental femoral bone defects, with shorter time in frame, lower external fixation index, and reduced complications. Therefore, the SRN technique may be considered an optimal choice for treating patients with such conditions.
Commercial scale production of Yamabushitake mushroom (Hericium erinaceus (Bull.) Pers. 1797) using rubber and bamboo sawdust substrates in tropical regions
Authors: Chutimanukul Preuk , Phatthanamas Wongsakorn , Thepsilvisut Ornprapa , Chantarachot Thanin , Thongtip Akira , Chutimanukul Panita 
Published: August 2023

AbstractYamabushitake (Hericium erinaceus) is one of the most sought out mushrooms that is widely used for both direct consumption and medicinal purposes. While its demand increases worldwide, cultivation of the mushroom is limited to temperate areas and its production in tropical regions has never been explored. The aim of this study was to test the utilization of rubber and bamboo sawdust, alone or as a substrate mixture, for industrial scale Yamabushitake mushroom production. Five substrate treatments with various ratios of the two sawdust were compared for their physicochemical properties in relation to mushroom productivity. The highest mushroom fresh and dry (113.22 and 23.25 g, respectively), biological efficiency (42.61%), and cap size (9.53 cm) were obtained from the substrates containing 100% rubber sawdust, with the mushroom yield decreasing proportional to the ratio of bamboo sawdust. The 100% rubber sawdust substrate provided a higher initial organic matter and carbon content together with C:N ratio at 63.2%, 36.7% and 65.48, respectively, whereas the 100% bamboo sawdust provided higher nitrogen content (1.03%), which was associated with lower mushroom yield but higher number of fruiting bodies. As in the 100% rubber sawdust substrate, a comparable mushroom yield and growth attributes were also obtained in the 3:1 rubber-bamboo sawdust mixture substrate. Principle component analysis of the measured variables indicated a strong influence of substrate C:N ratio before spawning and the change in substrate electrical conductivity and N content after cultivation to the variation in mushroom productivity among the treatments. The results demonstrate the applicability of rubber sawdust and its combination with up to 25% of bamboo sawdust for Yamabushitake mushroom cultivation and provide the basis for substrate optimization in the tropical Yamabushitake mushroom industry through a circular economy framework.
Applying machine learning to consumer wearable data for the early detection of complications after pediatric appendectomy
Authors: Ghomrawi Hassan M. K. , O’Brien Megan K. , Carter Michela , Macaluso Rebecca , Khazanchi Rushmin , Fanton Michael , DeBoer Christopher , Linton Samuel C. , Zeineddin Suhail , Pitt J. Benjamin , Bouchard Megan , Figueroa Angie , Kwon Soyang , Holl Jane L. , Jayaraman Arun , Abdullah Fizan 
Published: August 2023

AbstractWhen children are discharged from the hospital after surgery, their caregivers often rely onsubjectiveassessments (e.g., appetite, fatigue) to monitor postoperative recovery as objective assessment tools are scarce at home. Such imprecise and one-dimensional evaluations can result in unwarranted emergency department visits or delayed care. To address this gap in postoperative monitoring, we evaluated the ability of a consumer-grade wearable device, Fitbit, which records multimodal data about daily physical activity, heart rate, and sleep, in detecting abnormal recovery early in children recovering after appendectomy. One hundred and sixty-two children, ages 3–17 years old, who underwent an appendectomy (86 complicated and 76 simple cases of appendicitis) wore a Fitbit device on their wrist for 21 days postoperatively. Abnormal recovery events (i.e., abnormal symptoms or confirmed postoperative complications) that arose during this period were gathered from medical records and patient reports. Fitbit-derived measures, as well as demographic and clinical characteristics, were used to train machine learning models to retrospectively detect abnormal recovery in the two days leading up to the event for patients with complicated and simple appendicitis. A balanced random forest classifier accurately detected 83% of these abnormal recovery days in complicated appendicitis and 70% of abnormal recovery days in simple appendicitis prior to the true report of a symptom/complication. These results support the development of machine learning algorithms to predict onset of abnormal symptoms and complications in children undergoing surgery, and the use of consumer wearables as monitoring tools for early detection of postoperative events.
Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function
Authors: Mortlock Sally , Houshdaran Sahar , Kosti Idit , Rahmioglu Nilufer , Nezhat Camran , Vitonis Allison F. , Andrews Shan V. , Grosjean Parker , Paranjpe Manish , Horne Andrew W. , Jacoby Alison , Lager Jeannette , Opoku-Anane Jessica , Vo Kim Chi , Manvelyan Evelina , Sen Sushmita , Ghukasyan Zhanna , Collins Frances , Santamaria Xavier , Saunders Philippa , Kober Kord , McRae Allan F. , Terry Kathryn L. , Vallvé-Juanico Júlia , Becker Christian , Rogers Peter A. W. , Irwin Juan C. , Zondervan Krina , Montgomery Grant W. , Missmer Stacey , Sirota Marina , Giudice Linda 
Published: August 2023

AbstractEndometriosis is a leading cause of pain and infertility affecting millions of women globally. Herein, we characterize variation in DNA methylation (DNAm) and its association with menstrual cycle phase, endometriosis, and genetic variants through analysis of genotype data and methylation in endometrial samples from 984 deeply-phenotyped participants. We estimate that 15.4% of the variation in endometriosis is captured by DNAm and identify significant differences in DNAm profiles associated with stage III/IV endometriosis, endometriosis sub-phenotypes and menstrual cycle phase, including opening of the window for embryo implantation. Menstrual cycle phase was a major source of DNAm variation suggesting cellular and hormonally-driven changes across the cycle can regulate genes and pathways responsible for endometrial physiology and function. DNAm quantitative trait locus (mQTL) analysis identified 118,185 independent cis-mQTLs including 51 associated with risk of endometriosis, highlighting candidate genes contributing to disease risk. Our work provides functional evidence for epigenetic targets contributing to endometriosis risk and pathogenesis. Data generated serve as a valuable resource for understanding tissue-specific effects of methylation on endometrial biology in health and disease.
Nonlinear interactions between vibration modes with vastly different eigenfrequencies
Authors: Shoshani Oriel , Shaw Steven W. 
Published: August 2023

AbstractNonlinear interactions between modes with eigenfrequencies that differ by orders of magnitude are ubiquitous in various fields of physics, ranging from cavity optomechanics to aeroelastic systems. Simplifying their description to a minimal model and grasping the essential physics is typically a system-specific challenge. We show that the complex dynamics of these interactions can be distilled into a single generic form, namely, the Stuart-Landau oscillator. With our model, we study the injection locking and frequency pulling of a low-frequency mode interacting with a blue-detuned high-frequency mode, which generate frequency combs. Such combs are tunable around both the high and low carrier frequencies. By discussing the analogy with a simple mechanical system model, we offer a minimalistic conceptual view of these complex interactions originating the frequency combs, together with showcasing their frequency tunability.
Luxury and legacy effects on urban biodiversity, vegetation cover and ecosystem services
Authors: Aznarez Celina , Svenning Jens-Christian , Pacheco Juan Pablo , Have Kallesøe Frederik , Baró Francesc , Pascual Unai 
Published: August 2023

AbstractSocio-economic and historical drivers shape urban nature distribution and characteristics, as luxury (wealth-related) and legacy (historical management) effects. Using remote sensing and census data on biodiversity and socio-economic indicators, we examined these effects on urban biodiversity and vegetation cover in Vitoria-Gasteiz (Basque Country). We also tested the luxury and legacy hypotheses on regulating ecosystem services (ES) and explored predictor interactions. Higher educational attainment positively correlated with urban biodiversity, confirming the luxury effect, but had no effect on vegetation cover or ES. Older areas had higher vegetation cover and ES evidencing a legacy effect with an inverse response on biodiversity, attributable to more recent management strategies promoting biodiversity in green spaces. Habitat quality amplified the luxury effect, while population density strengthened the legacy effect. Our results suggest that urban biodiversity is mainly driven by socio-economic factors, while vegetation cover and ES are influenced by management legacies in interaction with population density.
Long-term volcano evolution controlled by lateral collapse at Antuco volcano, southern Andes, Chile
Authors: Romero Jorge E. , Polacci Margherita , Arzilli Fabio , Schipper C. Ian , La Spina Giuseppe , Burton Mike , Parada Miguel A. , Norambuena Juan , Guevara Alicia , Watt Sebastian , Moreno Hugo , Franco Luis , Fellowes Jonathan 
Published: August 2023

AbstractBeyond the catastrophic environmental effects of large (>1 km3) volcanic landslides, their impact on underlying magmatic systems remains unclear. Chemical variations in post-collapse volcanic products, alongside dramatic eruptive behaviour transitions reported from several volcanoes, imply that surface unloading directly influences subsurface magmatic processes. By combining petrologic data with magma ascent models, we track the post-collapse (<7 ka) magmatic system evolution of Antuco volcano (Chile). During the pre-collapse period, low-explosivity eruptions were sourced from a hotter and deeper storage region. However, the landslide-induced unloading and decompression reactivated a pre-existing, shallower, silicic magma reservoir, favouring more explosive activity. The pre-collapse conditions were restored after edifice regeneration over a few thousand years. Since shallow magma reservoirs are common beneath volcanoes (e.g. in Etna, Villarrica, or Fuji), similar responses could follow future lateral collapses. These findings are relevant when assessing volcanic hazards at gravitationally unstable or collapsed volcanoes on a hundred- to thousand-year timescale.
What determines climate ambition? Analysing NDC enhancement with a mixed-method design
Authors: Peterson Lauri , van Asselt Harro , Hermwille Lukas , Oberthür Sebastian 
Published: August 2023

AbstractThe 2015 Paris Agreement relies on Nationally Determined Contributions (NDCs) to outline each country’s policies and plans for reducing greenhouse gas (GHG) emissions. To strengthen global climate action and achieve the Agreement’s temperature goal, it is crucial to enhance the ambition level of NDCs every 5 years. While previous studies have explored the ambition of initial NDCs, limited research has delved into the factors driving the enhancement or lack thereof in NDCs’ emission reduction plans. This study employs a mixed-method design to investigate the determinants of NDC enhancement. First, we analyse the updated or revised NDCs of 111 countries using quantitative methods. Second, we conduct qualitative case studies focusing on Brazil and South Africa. Our findings reveal that countries that engaged in stakeholder consultations with civil society, business, and labour groups prior to developing their updated or revised NDCs were more likely to enhance their greenhouse gas reduction targets. These results are further supported by the case studies. South Africa conducted comprehensive consultations and submitted an enhanced GHG target, while Brazil, which did not arrange open consultations, did not improve its target. This study underscores the significance of comprehensive and transparent stakeholder engagement processes, highlighting their potential to drive enhanced NDCs. By involving diverse stakeholders, including civil society, business, and labour groups, countries can foster greater ambition and effectiveness in their climate action, ultimately contributing to the global effort to combat climate change.