bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-reported outcomes for oral oncolytic therapy: A pilot study utilizing an electronic patient portal in a community cancer center
Authors: Saadeh Claire , Hill Maja , Snowaert Samuel 
Published: March 2023

Objective A pilot project was initiated to determine the feasibility of using an electronic patient portal, MyChart, for documentation of patient-reported outcomes for those receiving treatment with an oral oncolytic. Methods Documentation of patient-reported outcomes within the electronic medical record before and after implementing questionnaires through the use of MyChart was compared. Additional outcomes that were assessed included patient confidence and satisfaction, adherence rate, side effects, and documentation of provider interventions. Results Our findings indicate that the use of an electronic patient portal significantly increased the number of encounters documented within the electronic medical record from 1.8% ( N = 19 patients; 1 out of 55 potential encounters; retrospective analysis) to 27.5% ( N = 15 patients; 14 out of 51 potential encounters; prospective analysis) for those who utilized an electronic patient portal ( p < 0.001). Patient confidence and satisfaction were high, the adherence rate was 100% at 4 months, and side effects were generally mild. Provider follow-up was documented in the electronic medical record in 6 out of 8 patients when a flagged response was identified. Conclusions This pilot study indicates that the use of an electronic patient portal, MyChart, was feasible and improved documentation of patient-reported outcomes within the electronic medical record. Several information technologies and patient barriers were encountered throughout. Careful selection of patients who will embrace this technology is important.
Functional Impairments Associated With ADHD in Adulthood and the Impact of Pharmacological Treatment
Authors: Kosheleff Alisa R. , Mason Oren , Jain Rakesh , Koch Jennifer , Rubin Jonathan 
Published: March 2023

Objective: Among untreated adults, functional impairments associated with ADHD are widespread and cumulative, and can include social, educational, and professional impairments, increased risk of accidents and mortality, and reduced quality of life. Here, we review the most prominent functional impairments in adults with ADHD and summarize evidence describing the potential role of medication in improving outcomes. Method: Articles related to the search terms “ADHD,” “adult,” and functional impairments were identified through Google Scholar and PubMed and selected for inclusion based on four criteria: strength of evidence, relevance to current challenges in adult ADHD, impact on the field, and recency of the results. Results: We identified 179 papers to support the conclusions on the relationship between ADHD and functional impairments, and the impact of pharmacological therapy on functional impairments. Conclusion: This narrative review provides evidence that pharmacological treatment can be effective in minimizing not only the symptoms of ADHD, but its functional consequences as well.
Predictors of help-seeking behavior in mothers of preschoolers
Authors: Jackson Samuel T , Jaeger Allison J , Del Vecchio Tamara 
Published: March 2023

Mental health difficulties in the preschool years require early intervention, but preschool children are underserved in mental healthcare. One explanation might be that parents do not seek services because their problem recognition, or labeling, ability is lacking. While previous research demonstrates that labeling is positively associated with help-seeking, interventions aimed at improving help-seeking by improving labeling are not always successful. Parental perceptions of severity, impairment, and stress also predict help-seeking, but have not been examined alongside labeling. Thus, it is unclear how much they add to the parental help-seeking process. The present study simultaneously examined labeling and parental perceptions of severity, impairment, and stress on help-seeking. Participants (82 adult mothers of children ages 3–5 years) read vignettes describing preschool-aged children with symptoms of depression, anxiety, and ADHD, and answered a series of questions to assess their labeling and likelihood of help-seeking for each of the problems presented. Help-seeking was found to be positively associated with labeling ( r = .73; r = .60), severity ( r = .66), impairment ( r = .31), and stress ( r = .25). Furthermore, severity, impairment, and stress predicted endorsements of help-seeking above and beyond what was predicted by labeling alone ( R 2 change = .12; χ2 (3) = 20.03, p < .01). These results underscore the importance of parental perceptions of children’s behavior to the help-seeking process.
‘I felt like my senses were under attack’: An interpretative phenomenological analysis of experiences of hypersensitivity in autistic individuals
Authors: Taels Liesbeth , Feyaerts Jasper , Lizon Marie , De Smet Melissa , Vanheule Stijn 
Published: March 2023

While atypical sensory processes have become central to scientific explanatory models of autism, such models usually do not explicitly address first-person experiences of sensory processes by autistic individuals. Detailed phenomenological research of this subjective domain is nonetheless essential to ground explanatory accounts in the actual experiences and challenges faced by autistic individuals. Therefore, our study consisted of an interpretative phenomenological analysis of 18 semi-structured interviews with autistic individuals about their experiences of hypersensitivity. Overall, our analysis showed how hypersensitivity pertained to disturbances at a basic level of bodily self-experience and also affected other crucial phenomenological experiential dimensions such as the subjective perception of time and space, sense-making processes, intersubjectivity, and moods. Hypersensitivities were described by participants as intrusive experiences of being vulnerably exposed to overwhelming stimuli that invaded their bodies and were simultaneously related to an invasive, chaotic, unpredictable or threatening perception of the (social) environment. Our study highlights the impact of hypersensitivities on experiential domains outside the strict sensory register, thereby providing further evidence for altered sensory processing as a potential core mechanism involved in a variety of autistic symptoms. Our study also indicates the clinical importance of therapeutic interventions that act on a fragile sense of embodiment in autism. Lay abstract Research shows that the way autistic individuals perceive and process sensory stimuli differs from those of non-autistic people. However, while current research often focuses on what sensory differences in autism are and which neurocognitive processes may explain these, it often does not explicitly address what it is like to experience the world through the senses of an autistic person. To explore this understudied dimension, we conducted 18 in-depth interviews with autistic individuals in order to better understand how they personally experienced hypersensitivity from a first-person perspective. Participants described hypersensitivity as a feeling of being bombarded by intrusive stimuli that seemed to invade their bodies and from which they had difficulties distancing themselves. They also indicated how due to hypersensitivity they often perceived their (social) environment as invasive, chaotic, unpredictable or threatening. Hypersensitivities were thus not only described as unsettling bodily experiences but also related to challenges in perceiving, understanding and interacting with the (social) world. By focussing on the subjective dimension of sensory processing in autism, our study thus highlights how sensory difficulties are not peripheral features of autism but play an essential part in the daily challenges faced by autistic individuals.
Coping with a language loss: A case of linguistic and cultural re-encoding of memories in language attriters
Authors: Sorokina Anastasia 
Published: March 2023

Aims and objectives: This study investigates the effects of language loss on bilingual autobiographical memory. More specifically, the study focuses on whether severe language loss would lead to any linguistic changes and/or interfere with how memories are recalled and shared. Methodology: Autobiographical memories were elicited with the help of a cued-recall technique and memory questionnaire from two groups of immigrants—attriters (who experienced significant language loss) and bilinguals (who retained their first language proficiency). Data and analysis: The data set consisted of pre-immigration memories that were originally encoded in the first language, Russian. The frequency of recall (i.e., sharing memories with others as well as reminiscing) and linguistic components (i.e., words) of memories elicited from the attriters and bilinguals were analyzed quantitatively and qualitatively. Findings and conclusion: Overall, attriters were able to recall memories that were originally encoded in the forgotten language. They also reported reminiscing about their pre-immigration memories and sharing their memories with others. However, attriters revealed that the pre-immigration memories came to them with words in the second language, English, which was not the case with bilinguals. Attriters also reframed memories for several Russian culture-specific items and events. This finding is indicative of memory re-encoding—a phenomenon when memories are updated, stored, and subsequently retrieved with added information. While this finding points to the bilingual mind’s ability to adapt to language loss, it may also suggest linguistic and cultural assimilation under the influence of the new language and culture. Originality: This is the first investigation of autobiographical memory in bilinguals with severe language loss that highlights the malleability and adaptability of the bilingual mind as well as the importance of language maintenance.
Disappearing multiple visceral aneurysms in Vascular Ehlers-Danlos syndrome
Authors: Pennetta Federico Francisco , Ferrer Ciro , Tonidandel Luca , Coscarella Carlo , Vagnarelli Simone , Giudice Rocco 
Published: March 2023

Objective To assess the complex management of arterial anomalies in Vascular Ehlers-Danlos Syndrome (vEDS). Methods We report the case of a 34-year-old male, diagnosed with vEDS, who presented with acute intraperitoneal hemorrhage caused by the rupture of a splenic artery aneurysm, treated in emergency with coil embolization and splenectomy. Computed Tomography (CT) scan showed the concomitant presence of right renal artery (RRA) and common hepatic artery (CHA) aneurysms. Results Both aneurysms were conservatively managed and the patient went through serial CT imaging. After 3 months, rapid regression of the vascular abnormalities led to complete disappearing of RRA and CHA aneurysms, confirmed at 24-month imaging follow-up. In the same time span, two pseudoaneurysms developed in other sites used for transarterial access, requiring two secondary interventions. The present case emphasizes the unpredictability of disease’s evolution and arterial complications in vEDS. Conservative management of complex lesions such as visceral artery aneurysms, which in this case resulted to be the best strategy, avoided the risks associated with surgical intervention in such fragile tissues. The reported complications underline that operative indications should be carefully weighed in these patients.
Prognostic impact of clinical outcome after endoscopic gastroduodenal stent placement for malignant gastric outlet obstruction: a multicenter retrospective cohort study using a time-dependent analysis
Authors: Hodo Yuji , Takatori Hajime , Komura Takuya , Asahina Yoshiro , Chiba Tomoyoshi , Takabatake Hisashi , Hasatani Kenkei , Nishino Ryuhei , Yano Masaaki , Takata Yoshiko , Suda Tsuyoshi , Shugo Haruhiko , Nakanishi Hiroyoshi , Yamada Kazutoshi , Miwa Kazuhiro , Kaji Kiichiro , Nishitani Masaki , Miyazawa Masaki , Yamashita Taro 
Published: March 2023

Background: Endoscopic gastroduodenal stent (GDS) placement is widely used as a safe and effective method to rapidly improve gastrointestinal symptoms of malignant gastric outlet obstruction (MGOO). While previous studies reported the utility of chemotherapy after GDS placement for prognosis improvement, they did not fully address the issue of immortal time bias. Objectives: To examine the association between prognosis and clinical course following endoscopic GDS placement, using a time-dependent analysis. Design: Multicenter retrospective cohort study. Methods: This study included 216 MGOO patients who underwent GDS placement between April 2010 and August 2020. Data of patient baseline characteristics, including age, gender, cancer type, performance status (PS), GDS type and length, GDS placement location, gastric outlet obstruction scoring system (GOOSS) score, and history of chemotherapy before GDS were collected. The clinical course following GDS placement was evaluated by GOOSS score, stent dysfunction, cholangitis, and chemotherapy. A Cox proportional hazards model was used to identify prognostic factors after GDS placement. Stent dysfunction, post-stent cholangitis, and post-stent chemotherapy were analyzed as time-dependent covariates. Results: Mean GOOSS scores before and after GDS were 0.7 and 2.4, respectively, with significant improvement after GDS placement ( p < 0.001). The median survival time after GDS placement was 79 [95% confidence interval (CI): 68–103] days. In multivariate Cox proportional hazards model with time-dependent covariates, PS 0–1 [hazard ratio (HR): 0.55, 95% CI: 0.40–0.75; p < 0.001], ascites (HR: 1.45, 95% CI: 1.04–2.01; p = 0.028), metastasis (HR: 1.84, 95% CI: 1.31–2.58; p < 0.001), post-stent cholangitis (HR: 2.38, 95% CI: 1.37–4.15; p = 0.002), and post-stent chemotherapy (HR: 0.01, 95% CI: 0.002–0.10; p < 0.001) significantly affected prognosis after GDS placement. Conclusion: Post-stent cholangitis and tolerability to receive chemotherapy after GDS placement influenced prognosis in MGOO patients.
Long-term clinical outcomes of arthroscopic supraspinatus tendon repair using the single anchor tension band technique - Minimum 5-years follow-up
Authors: Galbraith John G , Davey Martin S , Bigsby Ewan , Mohammed Khalid D , Malone Alex A 
Published: March 2023

Background The primary aim of this study was to assess the long-term patient reported outcomes of arthroscopic rotator cuff tear (ARCR) using a single anchor tension band (TB) technique for small and medium supraspinatus tears at minimum 5-years follow-up. Methods A retrospective cohort study of consecutive ARCRs of small and medium supraspinatus tears using a knotless single anchor TB technique with minimum 5-year follow-up was carried out. Outcomes of interest included: range of motion (ROM) on examination under anaesthesia (EUA), visual analogue scale (VAS), American Shoulder and Elbow Surgeons (ASES) scores, Oxford Shoulder Score (OSS) and Short-Form (SF-12). Results From 243 consecutive ARCR procedures, 82 patients with a mean age of 55 ± 9.5 years met the inclusion criteria at 6.7 ± 1.5 years follow-up. There were significant improvements in VAS (5.5 ± 2.2 vs. 0.7 ± 1.5), ASES (47.6 ± 16.8 vs. 92.8 ± 13.0), OSS (31.3 ± 7.2 vs. 45.3 ± 3.5) and SF-12 (37.6 ± 7.6 vs. 50.3 ± 7.7) post-operatively (all p < 0.001). Conclusions The single anchor TB ARCR technique has excellent patient reported outcomes at a minimum of 5 years and is suitable for supraspinatus tears smaller than 20 mm in the sagittal plane. Level of evidence Level IV; Consecutive Case Series
A 10.5-year follow-up of walking with unilateral spastic cerebral palsy
Authors: Bonnefoy-Mazure Alice , De Coulon Geraldo , Lascombes Pierre , Bregou Aline , Armand Stéphane 
Published: March 2023

Purpose: The purpose of this study was to describe gait evolution in patients with unilateral spastic cerebral palsy (USCP) using modified Gait Profile Score (mGPS without hip rotation), Gait Variable Score (GVS), walking speed, and the observed effects of single-level surgery (SLS) after 10 years. Methods: Fifty-two patients with USCP (Gross Motor Function Classification System I) and data from two Clinical Gait Analyses (CGAs) were included. The evolution of patients’ mGPS, GVS, and walking speed were calculated. Two “no surgery” and “single-level surgery” patient categories were analyzed. Paired t-tests were used to compare the data between CGAs and as a function of treatment category. Pearson’s correlations were used to examine relationships between baseline values and evolutions in mGPS and walking speed. Results: Mean ages (SD) at first and last CGAs were 9.3 (3.2) and 19.7 (6.0) years old, respectively, with an average follow-up of 10.5 (5.6) years. Mean mGPS for the patients’ affected side was significantly lower at the last CGA for the full cohort: baseline = 8.5° (2.1) versus follow-up = 7.2° (1.6), effect size = 0.73, p < 0.001. Significant improvements in mGPS and GVS for ankle and foot progression were found for the SLS group. The mGPS change and mGPS at baseline (r = −0.79, p < 0.001) were negatively correlated. Conclusions: SLS patients demonstrated a positive long-term change in gait pattern over time. The group that had undergone surgery had worse gait scores at baseline than the group that had not, but the SLS group’s last CGA scores were relatively closer to those of the “no surgery” group. Level of evidence: This was a retrospective comparative therapeutic study (level III).
Postural Control Deficits During Static Single-leg Stance in Chronic Ankle Instability: A Systematic Review and Meta-Analysis
Authors: Xue Xiao’ao , Wang Yiran , Xu Xiaoyun , Li Hong , Li Qianru , Na Yuyan , Tao Weichu , Yu Le , Jin Zhengbiao , Li Hongyun , Wang Ru , Hua Yinghui 
Published: March 2023

Context: Postural control deficits arising from injured ankles are central to chronic ankle instability (CAI) and its persistent symptoms. This is usually measured by recording the center of pressure (CoP) trajectory during static single-leg stance using a stable force plate. However, existing studies have produced conflicting results on whether this mode of measurement adequately reveals the postural deficits in CAI. Objective: To determine whether postural control during static single-leg stance is impaired in CAI patients when compared with uninjured healthy controls. Data Sources: Literature databases, PubMed, Embase, Web of Science, Cochrane Library, Scopus, CINAHL, and SPORTDiscus, were searched from inception to April 1, 2022, using ankle-, injury-, and posture-related terms. Study Selection: Two authors independently performed the step-by-step screening of article titles, abstracts, and full texts to select peer-reviewed studies investigating CoP trajectory during static single-leg stance using a stable force plate in CAI patients and healthy controls. A total of 13,637 studies were reviewed, and 38 studies (0.003%) met the selection criteria. Study Design: Meta-analyses of descriptive epidemiological study. Level of Evidence: Level 4. Data Extraction: CoP parameters, sway directions, visual condition, and numerical data (means and standard deviations) were extracted. Results: The injured ankles of CAI patients had higher standard deviations of sway amplitude in both anterior-posterior and medial-lateral directions (standardized mean difference [SMD] = 0.36 and 0.31, respectively) under conditions of open eyes than controls. Higher mean sway velocity in anterior-posterior, medial-lateral, and total directions (SMD = 0.41, 0.37, and 0.45, respectively) with closed eyes was also found. Conclusion: CAI patients had deficits of postural control during static single-leg stance, and these deficits were identified by the CoP trajectory. Further methodological explorations of CoP parameters and corresponding test conditions are required to enhance the sensitivity and reliability of postural deficit assessments in CAI using force plates.
Creative Art Therapy for Improving Depression, Anxiety, and Stress in Patients with Stroke: A Quasi-Interventional Study
Authors: Alwledat Khadeja , Al-Amer Rasmieh , Ali Amira Mohammed , Abuzied Yacoub , Adnan Khudeir Feras , Alzahrani Naif S. , Alshammari Saleh R. , AlBashtawy Mohammed , Thananayagam Thanuja , Dehghan Mahlagha 
Published: March 2023

Introduction Creative art therapy is a psychotherapeutic approach used to enhance the mental health status of patients. Objectives This study aimed to evaluate the effect of creative art therapy on the levels of depression, anxiety, and stress in Jordanian patients following stroke. Methods One-group pretest–posttest design was used; it included four sessions of creative art therapy which were conducted as two sessions for two weeks. This study recruited 85 participants who were within three months poststroke diagnosis. The Depression, Anxiety, and Stress Scale was used to assess the levels of psychological reactions pre and post creative art therapy intervention. Results The data showed that there was a statistically significant improvement in the levels of depression ( t = 37.98; p < .001), anxiety ( t = 20.59, p < .001), and stress ( t = 35.52, p < .001) post-intervention. There was a statistically significant improvement in the study-related psychological aspects following creative art therapy. Conclusion The findings of this study suggest that creative art therapy is a valuable method to complement other types of treatments among patients with stroke, resulting in positive patient mental health outcomes. Creative art therapy could be used as a psychotherapeutic approach to manage mental health complexities among patients with stroke. Health policymakers are invited to use the findings of this study to establish tailored counselor services using this new psychotherapeutic approach.
Tibiotalocalcaneal Arthrodesis: A Retrospective Comparison Between Nails and Lateral Locking Plate Complications
Authors: Rosemberg Dov Lagus , Macedo Rodrigo Sousa , Sposeto Rafael Barban , Sakaki Marcos Hideyo , Godoy-Santos Alexandre Leme , Fernandes Tulio Diniz 
Published: March 2023

Background: Tibiotalocalcaneal arthrodesis is a well-established procedure to treat some hindfoot diseases. Currently, the most used implants are retrograde intramedullary nails and locking plates combined with lag screws, but there are few articles comparing differences regarding the complications. Methods: We have retrospectively analyzed the medical records and the radiographs of patients older than 18 years who underwent this procedure in our service between 2005 and 2019 through retrograde intramedullary nails or lateral locking plates and compression screws with at least 12 months of follow-up and with no history of osteomyelitis in these bones. Results: We evaluated a total of 67 patients; of these, 48 received retrograde intramedullary nail implants and 19 received locking plates and compression screws. The overall mean age was 48 years; the median follow-up time was 64.3 months. The complication rate was 60.4% for the intramedullary nail procedure and 52.6% for the locking plate combined with compression screws procedure. Conclusion: No significant differences were found in the complication rates between the 2 implants. Level of Evidence: Level V, Case series