bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deciphering Aphanomyces eutieches-pea-biocontrol bacterium interactions through untargeted metabolomics
Authors: Hossain Zakir , Zhao Shuang , Liu Kui , Li Liang , Hubbard Michelle 
Published: July 2023

Abstract
Aphanomyces euteiches causes root rot in pea, leading to significant yield losses. However, the metabolites involved in this pathosystem have not been thoroughly studied. This study aimed to fill this gap and explore mechanisms of bacterial suppression of A. euteiches via untargeted metabolomics using pea grown in a controlled environment. Chemical isotope labeling (CIL), followed by liquid chromatography-mass spectrometry (LC-MS), was used for metabolite separation and detection. Univariate and multivariate analyses showed clear separation of metabolites from pathogen-treated pea roots and roots from other treatments. A three-tier approach positively or putatively identified 5249 peak pairs or metabolites. Of these, 403 were positively identified in tier 1; 940 were putatively identified with high confidence in tier 2. There were substantial changes in amino acid pool, and fatty acid and phenylpropanoid pathway products. More metabolites, including salicylic and jasmonic acids, were upregulated than downregulated in A. euteiches-infected roots. 1-aminocyclopropane-1-carboxylic acid and 12-oxophytodienoic acid were upregulated in A. euteiches + bacterium-treated roots compared to A. euteiches-infected roots. Most of the metabolites upregulated in response to A. euteiches infection were not different from control levels in A. euteiches + bacterium-treated plants. The results of this study could facilitate improved disease management.
Stochastic Ground Motion Simulation of the 26 September 2019 Mw 5.8 Silivri (Istanbul) Earthquake
Authors: Yenihayat Nesrin , Çaktı Eser , Şeşetyan Karin 
Published: July 2023

Abstract
The aim of using simulation techniques to provide generated ground motion data is to extend our knowledge on the effect of earthquakes and understanding their physical properties. Moreover, to fill the seismic gaps in case of insufficient recorded data in any region, ground motion simulations are widely used for earthquake engineering and seismology purposes. High-frequency accelerations have incoherent behavior because of unpredictable irregularities and heterogeneities associated with faulting and wave prpopagation. Simulations of ground motions frequencies beyond > 1 Hz can be represented with stochastic methods using simplified model representations of source, path and site effects. In this paper, stochastic simulations are performed for the recordings of the 26 September 2019 Silivri, Istanbul earthquake, using a finite fault simulation approach with a dynamic corner frequency. The main target is to create a valid synthetic model database with consistent source, path, and site parameters in the region that can be implemented in future simulation efforts. In calibration, we have used the recordings at 59 widely distributed stations in Istanbul located on different site conditions with epicentral distances ranging from 23 to 101 km. Four different frequency-dependent Q models were tested to obtain the best fit with the observations. By comparing generated ground motions to the observed ones, optimum source parameters and crustal characteristics were estimated. The calibrated model parameters have been obtained from the set of best-fit data with observed ground motion in frequency domain. Synthetic PGAs have been compared with the NGA-West2 Ground Motion Models (GMMs). Furthermore, spatial distributions of the ground motion intensity parameters were obtained and compared with available damage observations in Istanbul due to this earthquake. In conclusion, the results of the simulation were in good agreement with the recorded ones, both in time and frequency domains. The results indicate that the proposed stochastic model can be used to simulate ground motion distributions in Istanbul and beyond from past and future events in the region.
Vertical land motion component is underestimated in sea-level projections from northern Spain
Authors: Li Tanghua , García-Artola Ane , Shaw Timothy , Peng Dongju , Walker Jennifer , Cearreta Alejandro , Horton Benjamin 
Published: July 2023

Abstract

Coastal populations are susceptible to relative sea-level (RSL) rise and accurate projections are necessary for coastal adaptation. Local RSL rise may deviate from the global mean sea-level rise because of vertical land motion (VLM) but this is often inadequately estimated. Here, we estimated the VLM for the Oka estuary, northern Spain and compared it to the VLM component of sea-level projections in the Intergovernmental Panel on Climate Change (IPCC) Sixth Assessment Report (AR6) and the Spanish National Climate Change Adaptation Plan (NCCAP). To estimate VLM, we updated the late Holocene RSL data from the Atlantic coast of Europe and compared it with two 3D glacial isostatic adjustment (GIA) models. Both models fit well with RSL data except in the Oka estuary. We derived a VLM rate of -0.96 mm/yr for the Oka estuary using the residuals of GIA misfits and further validated this rate with nearby Global Navigation Satellite Systems, satellite altimetry and tide gauge data. Incorporating the updated estimate of VLM in IPCC AR6 RSL projections under a moderate emissions scenario increased the rate of RSL rise by 14.4% by 2030, 10.6% by 2050, and 9.9% by 2150 compared to the original IPCC AR6 projections, and also increased the magnitude of RSL rise by ~ 60% by 2035 and 2090 compared with projections from the Spanish NCCAP. Our study demonstrates the potential and capability of late Holocene RSL data to constrain the VLM component of sea-level projections.
Self-directed versus peer-supported self-management for mental and sexual wellbeing after acquired brain injury: protocol for a feasibility randomised controlled trial
Authors: Wright Hayley , Walker-Clarke Aimee , Drummond Avril , Kidd Lisa , Yeates Giles , Williams Deborah , McWilliams David , Clyne Wendy , Clark Cain C. T. , Kimani Peter , Turner Andy 
Published: July 2023

Abstract
Background
Acquired brain injury (ABI) can lead to biopsychosocial changes such as depression, low self-esteem, and fatigue can cause, and be caused by, sexual issues affecting relationships and wellbeing. Given the relationship between sexual wellbeing and mental health, it is feasible that supporting sexual wellbeing will benefit psychological wellbeing. However, neurorehabilitation is inconsistent and often inadequate across the UK, and psychological, sexual, and social support is lacking. Research shows that self-management and peer-support programmes can improve quality of life, self-efficacy, and psychological wellbeing after brain injury. This protocol describes a feasibility randomised controlled trial (RCT) of a digital self-management programme to support mental and sexual wellbeing (known as HOPE4ABI), co-designed with and for people with ABI.
Methods
This mixed-methods feasibility RCT has two parallel trial arms of the 8-week digital HOPE4ABI self-management programme. Eligibility criteria includes: age > 18 years, sustained an ABI > 3 months prior to trial entry, access to internet enabled device, and ability to engage with the intervention. Referrals to the study website will be made via National Health Service (NHS), social media, and partnering organisations. Sixty eligible participants will be randomised at a ratio of 1:1 to peer-supported (n = 30) or self-directed (n = 30) HOPE4ABI programme. Primary feasibility outcomes include recruitment and retention rates, engagement, adherence, and usage. Secondary outcomes relate to standardised measures of quality of life, sexual wellbeing, and mental wellbeing. Participants and peer-facilitators will be interviewed after the course to assess acceptability across both trial arms.
Discussion
This feasibility trial data is not sufficiently powered for inferential statistical analyses but will provide evidence of feasibility of a full RCT. Quantitative trial data will be analysed descriptively, and participant screening data representing age, ethnicity and gender will be presented as proportions at group level. This data may indicate trends in reach to particular demographic groups that may inform future recruitment strategies to widen participation. Progression to a definitive trial will be justified, if predetermined criteria are met, relating to recruitment, retention: engagement, and acceptability.
Trial Registration
ISRCTN46988394 registered on 1st March 2023.
Single low-dose of denosumab as a triggering agent for MRONJ development in a patient with osteoporosis Case report and mini-review
Authors: Szaraz David , Perina Vojtech , Treglerova Jana , Machacek Ctirad , Zendulka Ondrej , Linhartova Petra Borilova 
Published: July 2023

Abstract
Both denosumab (DNO) and bisphosphonates (BP), antiresorptive drugs (ARDs) used for the treatment of osteoporosis and oncological disorders, are known for their potential to cause medication-related osteonecrosis of the jaws (MRONJ). Besides ARDs, statins were recently associated with MRONJ development, especially in patients taking higher doses of statins for a longer period of time. Here, we report a case of a woman with osteoporosis who rapidly developed MRONJ stage III after only a single low dose of DNO. The patient was taking statins (rosuvastatin) for 7 years and had also been on BP (alendronate) for 4 years previously but this treatment was discontinued for approximately 1.5 years before MRONJ development. We performed a literature review of cases with MRONJ triggered by a single low dose of DNO and of cases with statin-induced MRONJ in patients not using ARD. Because the MRONJ development after a single low dose of DNO is rare, only eleven cases were previously described. We suggest that (i) in some patients, long-term use of statins and BP may lead to a higher susceptibility of MRONJ development after DNO exposure and (ii) that all predisposing factors to MRONJ development including the necessity of any dental procedures should be considered before DNO therapy is initiated.
Sound Design for Paintings in Virtual Art Exhibitions
Authors: Baratè Adriano , Ludovico Luca Andrea , Presti Giorgio 
Published: July 2023

Abstract
This paper starts with an overview of virtual art exhibitions, discussing their advantages and limitations compared to physical galleries. Then, it introduces the concepts of sound design, specifically sonification and musification, and their applicability in virtual art exhibitions. The potential for enhanced immersion through the integration of sound is explored. The paper presents the implementation of a demo web platform using the Unity game engine, highlighting the technical details and design choices involved. This platform serves as a practical example of incorporating sound design principles into virtual art exhibitions. The paper aims to contribute to the understanding of the role of sound in enhancing the immersive experience of virtual art exhibitions, providing insights for researchers, artists, and developers in the field.
Construction and analysis of ceRNA networks in the liver of black rockfish (Sebastes schlegelii) following Aeromonas salmonicida infection
Authors: Liu Xiantong , Wang Ningning , Yu Haohui , Zhang Xiaoyan , Li Chao , Cao Min 
Published: July 2023

Abstract
Given the dual roles in immune function and metabolism, liver can be selected as an interesting candidate to bridge host defense and metabolic adjustments during pathogen infections in teleost. In order to dissect the roles of liver in the immune response of Sebastes schlegelii, detection of activities of SOD, CAT and GPX4, systematic analysis of circRNA, miRNA and mRNA expression profiles, as well as circRNA-miRNA-mRNA regulatory networks in the liver of S. schlegelii following Aeromonas salmonicida infection were performed in the present study. The present results demonstrated the content of SOD, CAT and GPX4 increased significantly at early infection stage to protect the liver tissue from excessive damage. Meanwhile, 622 circRNA-miRNAs pairs, 78 miRNA-mRNA pairs and 327 circRNA-miRNA-mRNA pairs were identified in our study. These differently expressed circRNA and mRNA were related with LMNB1, DMBT1, NAMPT, IFIT1, CELSRs, PYGL etc. GO and KEGG enrichment analyses showed that differently expressed genes are related with TLR signal pathway, RIG signal pathway, PPAR signal pathway etc. These results revealed an antibacterial ceRNA network in the liver of S. schlegelii post A. hydrophila infection, which provided new clues and insights into the immune mechanisms of teleost.
Preparation of surface modified montmorillonite and its application for adsorption of phenolic compounds from olive mill wastewater
Authors: Arabmofrad Sara , Jafari Seid Mahdi , Lazzara Giuseppe , Ziaiifar Aman Mohammad , Tabarestani Hoda Shahiri , Bahlakeh Ghasem , Calvino Martina Maria , Sarvi Mehdi Nasiri 
Published: July 2023

Abstract
To recover phenolics from olive mill wastewater (OMW), adsorption was performed and compared among raw montmorillonite (Mt) and three modified-Mt forms. The Mt was modified with tetradecyl trimethylammonium bromide (TTB), cetyl trimethylammonium bromide (CTB), and didodecyl dimethylammonium bromide (DDB). The effect of adsorption time, pH and adsorbent concentration on the adsorption efficiency (AE) of phenolics from OMW were investigated. Experimental results revealed that the maximum AE% (93.43%) of TTB-Mt-1 was obtained at pH = 4.7, adsorbent concentration of 0.66 g/L. The Mt and TTB-Mt-1 before and after adsorption in optimum situation were characterized by X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy in order to establish the adsorption behavior-properties relationship. The results show there was successful phenolics adsorption on TTB-Mt-1. The equilibrium data of adsorbed phenolics was fitted well to Langmuir models and the kinetic data indicated that the best fit of experimental data was pseudo-second order model.
O3 decomposition to O2 on surfaces of Silicon nanocage and Carbon nanocage as effective catalysts
Authors: Al-dolaimy F. , Al-Khafaji Ali Hussein Demin , Ibrahim Israa Taha , Najm Mazin A.A. , Alawadi Ahmed Hussien , Alsaalamy Ali Hashiem 
Published: July 2023

Abstract
In this study, potential of Sc-C82 and Sc-Si82 as effective catalysts for O3 decomposition are examined through LH and ER mechanisms. The activation barrier energy and Gibbs free energy of reaction steps for O3 decomposition through the of LH and ER mechanisms on Sc-C82 and Sc-Si82 nanocages are calculated. Results shown that the Sc-C82 and Sc-Si82 nanocages have the negative values of ∆Eformation are stable nano-catalysts from thermodynamic viewpoints. The Sc atoms are catalytic positions to adsorb the O3 molecules and other important species of O3 decomposition through LH and ER mechanisms. The Sc-Si82 nanocage for O3 decomposition has lower Eacivation values and more negative ∆Greaction values than Sc-C82 nanocage. The Eacivation value of rate-determining step for O3 decomposition through LH mechanism is lower than ER mechanism. The Sc-Si82 nanocage has higher catalytic activity than Sc-C82 nanocage for O3 decomposition. The Sc-C82 and Sc-Si82 nanocages can catalyze the reaction steps of O3 decomposition through LH and ER mechanisms with high performance at normal temperature.
Novel susceptibility genes and molecular mechanisms identified in relation to mitochondrial dysfunctions in Parkinson’s disease
Authors: Li Dunhui , McDowall Simon , McIntosh Craig , Eddy Delenn , Zhang Fengqiu , Wang Tao 
Published: July 2023

Abstract
Background: Mitochondrial dysfunction is one of the major contributors in the pathogenesis of Parkinson’s disease (PD). However, the mechanisms and genes involved in mitochondrial dysfunction in PD have still not been fully uncovered.
Methods: The PD associated datasets were accessed via the gene expression omnibus (GEO) database, and we extracted 1870 mitochondrial dysfunction related genes (MDRGs) via the Genecards database. First, differentially expressed genes (DEGs) between PD and control samples were screened out by differential expression analysis, and samples (PD and control) were considered as traits for weighted gene co-expression network analysis (WGCNA) to yield the key modules. Then, we took the intersection of DEGs and genes from key modules to acquire a set of intersected genes, which were then intersected with MDRGs to obtain candidate genes. Next, the protein-protein interaction (PPI) analysis was implemented on candidate genes for identifying the hub genes, and they were subjected to single gene set enrichment analysis (GSEA). Finally, we constructed the drug-gene, transcription factor (TF)-mRNA-miRNA networks, and LASSO-Logistic regression model.
Results: Between the PD and control samples, 945 DEGs were filtered out. Subsequently, MEblue and MEyellow modules all had a strong correlation with traits, therefore they were considered as the key modules. We also yielded 444 intersected genes and 31 candidate genes, respectively. In addition, 7 hub genes: DVL2, DNMT1, ABL1, RAF1, NOTCH1, RELA, and PDGFRB were identified via the protein-protein interaction analysis. These genes were found to be related to ‘Parkinson's disease’, ‘oxidative phosphorylation’ and other functional pathways. Likewise, drugs such as resveratrol and bortezomib were predicted according to the hub genes, and the TF-mRNA-miRNA network consisting of relationship pairs, such as SREBF1-ABL1, and ‘hsa-mir-23b-3p’-NOTCH1, was constructed. Ultimately, we found that the LASSO-Logistic regression model had an excellent ability to distinguish PD samples from control samples.
Conclusion: Through bioinformatic analyses, we identified novel mitochondrial dysfunction related hub genes including DVL2, DNMT1, ABL1, RAF1, NOTCH1, RELA, and PDGFRB in PD, and explored their mechanisms of action in the tricarboxylic acid cycle and neuroactive ligand receptor interaction signaling pathways, providing new insights for studying the pathogenesis of PD.
An Optimization Method of Trochoidal Radius for Trochoidal Milling Hole based on the adaptive feed rate scheduling
Authors: Han Feiyan , Gu Zhi-Cheng , He Long-Long , Gou Tian-Mao , Zhang Chuan-Wei , Yang Man-Zhi , Shi Ren-Gui 
Published: July 2023

Abstract
The machining time is mainly related to the tool path and the corresponding feed speed, while the trochoidal tool path depends on the trochoidal step and trochoidal radius. The material removal rate is periodically distributed along the tool path in trochoidal milling a hole. But more than half of tool paths do not cut material in trochoidal milling a hole, so a constant feed speed in milling a hole will limit the machining efficiency. In this paper, a trochoidal radius optimization approach is presented to improve the efficiency of trochoidal milling a hole, which considering the optimal feed speed. Firstly, the mathematical representation of the trochoidal radius is formulated by analyzing the generation principle of trochoidal path, so the trochoidal radius could be determined under the premise of the hole diameter, maximum uncut radial material and the tool diameter are fixed. Furthermore, the trochoidal radius optimization model，which based on the adjusted feed speed, is established with the goal of minimizing the machining time. Secondly, an adaptive feed speed scheduling strategy for trochoidal milling is proposed, which is constrained by stable material removal rate and adjusted by a cubic polynomial algorithm. Finally, taking a hole machining as an example, simulation and experimental results show that the efficiency of applying the trochoid milling method proposed has increased by 13.8% compared to traditional helix milling method.
Design and thermal characteristic analysis of electricspindle cooling water jacket
Authors: Li ZhaoLong , Wang Baodong , Zhu Wenming , Wang Qinghai 
Published: July 2023

Abstract
High-speed motorized spindle is an important component of machine tool, and the influence of heat and deformation generated in the working process on the machining accuracy cannot be ignored. In order to reduce the temperature of the motorized spindle in the machining process, this paper first explore the influence of the flow rate of the motorized spindle cooling water on the cooling water jacket and the overall temperature change. The results indicate that when the flow rate exceeds a certain range, the overall temperature no longer drops, so there is an optimal flow rate in the choice of flow rate. Secondly, to solve the problem of uneven axial temperature distribution of the traditional spiral water jacket, four kinds of cooling water jackets with different structures were proposed. The simulation results show that the difference of temperature distribution inside the serpentine water jacket is small, the overall temperature was reduced by 1.8℃ and the pressure drop was reduced by 62.54kPa. It shows that the serpentine cooling water jacket has better cooling performance and can effectively reduce the thermal deformation of the motorized spindle shafting, so as to achieve the purpose of improving the machining accuracy.
Research on Investment and Financing Evolution Game of Supply Chain under the Intervention of the Logistics Platform
Authors: Zheng Mingxuan , Jian Ming , Dou Yaqin 
Published: July 2023

Abstract
This paper constructs an evolutionary game model of ‘financing enterprise-investor-platform’ and analyses the stability of the choice of multi-agent income strategy based on the logistics platform application scenario. In this paper, we discuss the effects of multidimensional factors, such as platform commission rate, platform reputation premium, loan interest rate, unit logistics cost and product price on the choice of multi-agent income strategy. Then, we study the stable strategy combination of a multi-agent evolutionary game, and the constraints formed by the combination of agent stability strategies are obtained. Finally, the research conclusions are verified through numerical simulation analysis. The research shows that the commission rate and logistics price of the logistics finance platform should be set within a reasonable range. When the logistics finance platform has a high expectation of reputation premium, it will be conducive to promoting financing enterprises and investors to adopt positive strategies to achieve win-win cooperation. The investor implements the credit strategy according to the principle of maximising its income and dominates the selection of enterprise financing strategy. The higher financing willingness of financing enterprises is conducive to promoting the implementation of credit easing strategy by the investor, ultimately achieving the optimal income of the three agents. However, the stable state of investor-enterprise cooperation depends on the platform to actively promote the establishment of a good trust mechanism.