bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular Protective Effect of Lignan Glycosides of Plumeria rubra
Leaves
Authors: Nagarajana Kandasamy , Khan Nayla , Ghai Roma , Grover Parul , Kapoor Garima , Alam Md Shamshir 
Published: May 2023

Introduction:
Cardiovascular disorders are the most prevalent and life-threatening
conditions affecting human beings. Therefore, this study aimed to assess the cardioprotective effect
of P. rubra leaves.

Aim:
Plumeria rubra L. has been used for ages in alternative/traditional systems of medicine for
several conditions, such as arthritis, toothache, pruritus, asthma, dysuria, gonorrhoea, diabetes,
and various types of inflammation.

Methods:
Acute toxicity studies were performed using OECD 423 guidelines, and cardiomyopathy
was induced in Wistar albino rats through an intraperitoneal injection of doxorubicin hydrochloride.
Different groups were established to study the efficacy of doxorubicin-treated P. rubra
leaf extract for 7 days. Blood pressure of both systolic and diastolic was recorded with noninvasive
blood pressure apparatus, and the mean was considered. Biochemical parameters were
analysed for serum and tissue homogenate viz. lactate dehydrogenase (LDH), thiobarbituric acid
reactive substance (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase
(CAT).

Results:
The LD50 cut-off range for the leaf extract was found to be 2,000 mg/kg body weight. P.
rubra leaf extract prevented the increase in heart rate (364.8 BPM) and mean blood pressure
(122.24 mmHg) and demonstrated good results as an antihypertensive agent. The treatment with
the extract was also found to revert the oxidative stress levels, as depicted by the MDA, SOD, and
catalase levels in heart tissue in treated rats.

Conclusion:
P. rubra leaf extract at a higher dose (200 mg/kg) exerted a compelling cardioprotective
action against cardiomyopathy induced by doxorubicin in Wistar rats due to the presence of
lignan glycoside, liriodendrin.
Effect of Telenursing on the Quality of Life of Caregivers of Older Patients
with Stroke
Authors: Mohammadi Fatemeh , Ardalan Hoda Bani , Dehghankar Leila , Motalebi Seyedeh Ameneh 
Published: May 2023

Background:
Family caregivers of stroke patients suffer from a high caregiving burden that affects their quality of life. Telenursing can provide caregivers and patients with services at the lowest cost and full access. Therefore, the aim of this study was to investigate the impact of telenursing on the quality of life of caregivers of older stroke patients.

Methods:
A total of 79 family caregivers of older stroke patients participated in this randomized clinical trial. The samples were selected from caregivers of older stroke patients admitted to a teaching hospital in Qazvin, Iran. They were randomly divided into two groups. The intervention group participated in an educational intervention for 12 weeks through telephone follow-up and social media. The Barthel Scale and the 36-item Short Form Survey (SF-36) were used for data collection. The chi-square and independent and paired t-tests were used to analyze the data.

Results:
The mean age of 79 caregivers participating in the study was 46.16 ± 11.32 years. No significant differences were found between the two groups at baseline. However, the independent t-test showed significant differences in the psychological subscale (p <0.001) between the intervention and control groups after the intervention. In addition, the results of the paired t-test showed significant improvements in the intervention group in physical (p <0.001) and psychological (p <0.001) subscales.

Conclusion:
The results of the current study support the effectiveness of telenursing in improving the quality of life of caregivers of older stroke patients.
Dashboard With Bump Charts to Visualize the Changes in the Rankings of Leading Causes of Death According to Two Lists: National Population-Based Time-Series Cross-Sectional Study
Authors: Tai Shu-Yu , Chi Ying-Chen , Chien Yu-Wen , Kawachi Ichiro , Lu Tsung-Hsueh 
Published: May 2023

Background
Health advocates and the media often use the rankings of the leading causes of death (CODs) to draw attention to health issues with relatively high mortality burdens in a population. The National Center for Health Statistics (NCHS) publishes “Deaths: leading causes” annually. The ranking list used by the NCHS and statistical offices in several countries includes broad categories such as cancer, heart disease, and accidents. However, the list used by the World Health Organization (WHO) subdivides broad categories (17 for cancer, 8 for heart disease, and 6 for accidents) and classifies Alzheimer disease and related dementias and hypertensive diseases more comprehensively compared to the NCHS list. Regarding the data visualization of the rankings of leading CODs, the bar chart is the most commonly used graph; nevertheless, bar charts may not effectively reveal the changes in the rankings over time.

Objective
The aim of this study is to use a dashboard with bump charts to visualize the changes in the rankings of the leading CODs in the United States by sex and age from 1999 to 2021, according to 2 lists (NCHS vs WHO).

Methods
Data on the number of deaths in each category from each list for each year were obtained from the Wide-ranging Online Data for Epidemiologic Research system, maintained by the Center for Disease Control and Prevention. Rankings were based on the absolute number of deaths. The dashboard enables users to filter by list (NCHS or WHO) and demographic characteristics (sex and age) and highlight a particular COD.

Results
Several CODs that were only on the WHO list, including brain, breast, colon, hematopoietic, lung, pancreas, prostate, and uterus cancer (all classified as cancer on the NCHS list); unintentional transport injury; poisoning; drowning; and falls (all classified as accidents on the NCHS list), were among the 10 leading CODs in several sex and age subgroups. In contrast, several CODs that appeared among the 10 leading CODs according to the NCHS list, such as pneumonia, kidney disease, cirrhosis, and sepsis, were excluded from the 10 leading CODs if the WHO list was used. The rank of Alzheimer disease and related dementias and hypertensive diseases according to the WHO list was higher than their ranks according to the NCHS list. A marked increase in the ranking of unintentional poisoning among men aged 45-64 years was noted from 2008 to 2021.

Conclusions
A dashboard with bump charts can be used to improve the visualization of the changes in the rankings of leading CODs according to the WHO and NCHS lists as well as demographic characteristics; the visualization can help users make informed decisions regarding the most appropriate ranking list for their needs.
INTERVENSI PENINGKATAN MUTU PELAPORAN INDIKATOR KINERJA PENGGUNAAN OBAT RASIONAL (POR) DI KABUPATEN KARAWANG
Authors: Yusrianti  , Erna Kristin  
Published: May 2023

Background:
Rational use of drugs plays a role in reducing morbidity and mortality in the community associated with the treatment of disease. Acute respiratory infections (ARI), diarrhea, and myalgia are diseases that are still commonly found and treated in primary
health centers, so far the three diagnoses are considered potential for irrational treatment. Data from existing reports can actually be used to identify the rationality of rational drug use, but until now the quality of report data is still poor. Therefore, how interventions can improve the quality of reporting the performance indicators of rational drug use in the Karawang District.
Objective: To improve the quality of reporting on performance indicators of rational drug use (POR) in Karawang District.
Methods: This study used a Quasi-Experimental research design with one- group pretest-posttest design, without a comparison group (control), in Karawang District in January - March 2020. Twenty officers reporting rational drug use in primary health centers were
selected by purposive sampling.
Results: Training interventions can improve the quality of reporting the performance indicators of rational drug use from the results of increased pretest after the training intervention (posttest) namely; report preparation process 25% to 80%, report completeness from
45% to 95%, timeliness from 15% to 75%, report compliance with technical instructions from 0% to 75%.
Conclusion: Providing interventions in the form of explanations of technical guidelines for rational drug use and training has been proven to improve the quality of reporting on performance indicators of rational drug use.
PEMETAAN DIMENSI KUALITAS PELAYANAN KESEHATAN HEWAN DARI PERSPEKTIF PENYEDIA DAN PENERIMA PELAYANAN MEDIS VETERINER
Authors: Alan Chandrasaputra  , Adi Utarini  , Ida Tjahajati  
Published: May 2023

Background:
The increasing demand for veterinary medical service quality from community has been increasing as seen on the raising of lawsuit for veterinary services since 2008. The description
of veterinary healthcare service quality in Indonesia was still unclear which part of quality dimension play the role to describe quality in veterinary healthcare service, especially in clinical area.
Objective: This study aimed to determine the dimensions that influence the quality of veterinary medical services from the perspective and expectations of clients and providers.
Methods: Qualitative Explorative as research design. Data Collection was done by 17 In-Depth Interview with 14 service providers and 3 service clients with addition 1 panel interview with 4 cat owner from cat lovers community and 1 panel interview with 2 dog owner.
All respondent must have experienced with providing/receiving veterinary healthcare service. Interview Data then transcribed followed
with Coding, Categorizing, and being made into Themes with Atlas.ti application which Themes become the fundamental of Quality Dimension of Veterinary Healthcare service.
Results: The interview produced 20 transcripts that were coded subcategory categories-themes. The results of the categories obtained have the capacity as a dimension of the quality of veterinary medical services in the form of: managerial services; internal
provider communication; professionalism of the provider; service competency, communication skills; client education, honesty and transparency; service security; service facilities; the dynamics of the world of service; service outputs and outcomes; and client assurance.
Conclusion: The category becomes the dimension of service quality in D.I. Yogyakarta contains 11 service quality dimensions which are divided into 3 themes. The theme is the value of service; communication and interaction between service providers and clients; and clients demands. This theme affects the veterinary medical services especially in the D.I area. Yogyakarta.
STRATEGI PENGEMBANGAN BALAI PENELITIAN DAN PENGEMBANGAN KESEHATAN BANJARNEGARA
Authors: Agung Puja Kesuma  , Laksono Trisnantoro  , Yodi Mahendrahata  
Published: May 2023

Background: Based on Permenkes No. 65 the year 2017, the Banjarnegara Health Research and Development (R&D) Unit is one oft he units under the NIHRD Ministry of Health, which has the task of conducting research and development of health with the advantage of leptospirosis control. The working area includes four provinces:
DI Yogyakarta, DKI Jakarta, West Kalimantan, and South Sulawesi. In addition to conducting excellent research, Banjarnegara Health R&D Unit also has to do health research based on program needs in the target area. The Banjarnegara Health R&D Unit needs to understand its strengths, weaknesses, opportunities, and challenges
through the identification of internal and external environments that can be using as a basis for developing strategic planning for organizational development.
Objective: Formulate alternative strategies for the development of The Banjarnegara Health R&D Unit.
Methods: Research A descriptive case study by using a holistic single case design plan. Variable research is the internal and external factor of Banjarnegara Health R&D Unit, development issues, and the strategies of develepment. Data obtained through in-depth interviews with the related informants, observation, and study of
documents.
Results: Internal environmental analysis to see the strengths and weaknesses of the Banjarnegara Health R&D Unit. Based on the results of internal environmental analysis, the Banjarnegara Health R&D Unit has considerable strength in terms of organizational as pects, HR experience, a budget that continues to increase every
year, and infrastructure. External environmental analysis opportunities that can be utilized by the Banjarnegara Health R&D Unit are excellent stakeholder support, opportunities to collaborate with various institutions, sources of research funding, availability of information technology, and regulations that support the research
climate. While the threats identified, require large budgets to keep abreast of medical or laboratory equipment technology, the development of potential epidemic diseases, limited recruitment of human resources and the potential to reduce PNBP.
Conclusion: Strategies that can be used Banjarnegara Health R&D
Unit for development are the development of services and products according to the needs of the stakeholders, the development of cooperation with strategic stakeholders, and the development of organizations with public service agency financial management patterns.
NURSE ENGAGEMENT DI RSU APRILLIA CILACAP
Authors: Bhintani Embriana  , Andreasta Meliala  , Widyawati  
Published: May 2023

Background: The success of the hospital industry, especially health services, depends on the participation of nurses in providing quality services to patients. In improving the quality of nurse services, hospital management must maximize nurses’ effectiveness, productivity, and innovation by encouraging positive attitudes in work by increasing nurse engagement. At RSU Aprillia Cilacap, the role of nurses is needed, which is shown through vigor, dedication and absorption.
Objective: This study measured the relationship between the variables of nurse engagement with the performance of nurses in inpatient installations.
Methods: Analytical descriptive quantitative research with cross sectional research design and research sample was 40 nurses.
The study measuring instrument is a questionnaire. The sampling technique used was a survey technique carried out by distributing questionnaires with a Likert Scale, involving the entire research sample. Data analysis used cross-tabulation of respondent characteristics on nurse engagement and nurse performance and bivariate analysis using the Chi-Square test (x2 ).
Results: There is no correlation between vigor and nurse performance (significance value (p) = 0.061 > 0.05), no correlation between dedication and nurse performance (significance value (p)= 0.291 > 0.05), and there is a correlation between absorption and nurse performance (value of significance). significancy (p) = 0.029
< 0.05).
Conclusion: The majority of nurses are at the level of engagement and nurse performance in the medium category. Thus, the manage ment needs to increase the engagement and performance of nurses by implementing nurse engagement with a work contract or MOU for new employees who have completed orientation and old employees who have been appointed as employees. Management needs to do retention so that potential nurses remain obedient and contribute generously to the hospital. The nurse recruitment process requires re-evaluation to obtain quality human resources and have values following the hospital’s vision, mission and goals.
GAMBARAN KINERJA RUMAH SAKIT SEBELUM DAN SESUDAH ERA JAMINAN KESEHATAN NASIONAL (JKN)
Authors: Wiwik Lestari  , Laksono Trisnantoro  , Ni Luh Putu Eka Putri Andayani  
Published: May 2023

Background:
Changes in the Hospital (RS) business environment have occurred significantly since JKN was introduced by BPJS Kesehatan. In this era, hospital managers are confused about the following changes and hospital performance is declining.
Objective: This study measures the service and financial performance before and after the JKN era.
Methods: Descriptive research design with quantitative methods at RSKIA SADEWA. The data used are secondary data from medical record data, hospital service data and financial statements (2011-2019)
Results:
After the implementation of the JKN program, there was an increase in the number of patient visits by 35.23% for outpatients and 36.43% for inpatients. The percentage of inpatients who used health insurance before the JKN era was only around 3%, and after the JKN era the number increased sharply to 73%. BOR increased by 1.83%. The SC rate decreased by 0.83%. Of all general patients with Caesarean Sectio in RSKIA SADEWA, an average of 54.75% were BPJS participants, but aborted their BPJS rights. The average hospital revenue increased by 93.72%, operating costs decreased
5.78%, HR costs increased 1.52% and net profit increased 4.26%. The proportion of hospital revenue obtained from BPJS patients on average is 26.38% of the total hospital revenue. The average ROA after JKN era increased 5,96%. The average financial quick ratio increased by 443%. The average financial solvency decreased by
0.03. The average CRR increased by 7%.
Conclusion: After the JKN era, there was an increase in the number of outpatient and inpatient visits. BOR increases, and SC rate decreases. Financial performance is measured by indicators of ROA, Quick Ratio, solvency and CRR. All indicators show an
improvement, and there is no change in the environment after implementing the JKN program. Strict evaluation is needed to maintain and improve the achieved performance.
GAMBARAN KESIAPSIAGAAN, RESPON, DAN PEMULIHAN PADA LEVEL KABUPATEN DALAM PENGENDALIAN PANDEMI COVID-19
Authors: Luqman Hakim  , Laksono Trisnantoro  , Ni Luh Putu Eka Putri Andayani  
Published: May 2023

Background: WHO has designated COVID-19 as a World Public Health Emergency. Success of the district level in handling COVID-19 is determined by the efforts made in these 3 phases: preparedness, response, and recovery. Sleman which has an urban character has its own vulnerabilitie and resources in the COVID-19 pandemic situation.
Objective: This study aimed to obtain an overview of the preparedness, response, and recovery in controlling COVID-19.
Methods: Qualitative research with a case study design in Sleman using the WHO Practical Actions in Cities to Strength Preparedness Checklist for the COVID-19 Pandemic and Beyond. The research subjects are informants who play a role in Task Force. Data were collected by means of documentation studies, observation, and in-depth interviews. Data validation was done by triangulation of sources and research data.
Results: Expert academics and communities are less involved. At the beginning of the pandemic, risk communication was less than optimal to form stakeholder awareness in the government and the community, resulting in poor public compliance with health protocols and public health measures. Mobility restrictions follow national directives. However, compliance monitoring and enforcement of violations are weak. Testing and tracing capacity is still far below the standard. The strategy to increase the capacity of COVID-19 beds in hospitals does not anticipate a surge in cases, and the formation of village shelters has not been maximized.
Conclusion: Planning and coordination require improvement by
taking into account existing vulnerabilities and involving all resources in the community. Risk communication strategies need to be strengthened according to changing situations and tailored to
specific targets using effective media. The government needs to make adjustments to public health measures carefully, taking into
account the epidemiological situation, the capacity of the health system, and the socioeconomic conditions of the community.
GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion
Authors: Zhang Hui , Mulya Anny , Nieuwoudt Stephan , Vandanmagsar Bolormaa , McDowell Ruth , C. Heintz Elizabeth , R.M. Zunica Elizabeth , Jason Collier J. , Bozadjieva-Kramer Nadejda , J. Seeley Randy , L. Axelrod Christopher , P. Kirwan John 
Published: May 2023

<p>Exercise is a first-line treatment for type 2 diabetes and preserves β-cell function by hitherto unknown mechanisms. We postulated that proteins from contracting skeletal muscle may act as cellular signals to regulate pancreatic β-cell function. We employed electric pulse stimulation (EPS) to induce contraction in C2C12 myotubes and found that treatment of β-cells with EPS-conditioned media (EPS-CM) enhanced glucose-stimulated insulin secretion (GSIS). Transcriptomics and subsequent targeted validation revealed Growth Differentiation Factor 15 (GDF15) as a central component of the skeletal muscle secretome. Exposure to recombinant GDF15 enhanced GSIS in cells, islets, and mice. GDF15 enhanced GSIS by upregulating the insulin secretion pathway in β-cells, which was abrogated in the presence of a GDF15 neutralizing antibody. The effect of GDF15 on GSIS was also observed in islets from GFRAL-deficient mice. Circulating GDF15 was incrementally elevated in patients with pre- and type 2 diabetes and positively associated with C-peptide in humans with overweight/obesity. Six weeks of high intensity exercise training increased circulating GDF15 concentrations, which positively correlated with improvements in β-cell function in patients with type 2 diabetes. Taken together, GDF15 can function as a contraction-induced protein that enhances GSIS through activating the canonical signaling pathway in a GFRAL-independent manner. </p>