bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Kebutuhan Bahasa Inggris untuk Mahasiswa Jurusan Teknik Informatika
Authors: Momo Lidia Lali 
Published: August 2023

ABSTRACT
As a global language, English appears as specific purpose for the Indonesian students. The technology needs for people has increased time by time, so does the English needs for non-native speaker. Here, English called English for Specific Purpose (ESP). So that, not just in daily life the students need English but to apply job or to master some vocabulary that relate with their department; in this case for information students at STIMIKOM Stella Maris Sumba. This study tends a qualitative design and the data were gained by an observation, documentation and the most important instrument was interview. The students concern that their major is always alongside with English, such as for empowering the language program, to apply job that require English as the one of requirements and to increase their information and communication technology knowledge. Besides that, the information technology students want to improve speaking and reading skills. These skills are important to prepare themselves to enter new job and connecting with many people in their life.
Key words: English for specific purpose, information technology

ABSTRAK
Sebagai bahasa internasional, bahasa Inggris hadir sebagai kebutuhan khusus bagi pelajar-pelajar di Indonesia. Dengan mengakui kebutuhan teknologi tiap orang terus berkembang dari tahun ke tahun, dengan demikian bahasa Inggris mampu menjawab dan membantu masyarakat untuk mampu beradaptasi dengan perubahan tersebut. Dalam hal ini bahasa Inggris hadir untuk memenuhi kebutuhan khusus bagi para pelajar yang akan memasuki dunia kerja. Jadi, kehadiran bahasa Inggris bukan hanya untuk memenuhi kegiatan sehari-hari tetapi kebutuhan untuk persiapan dalam memasuki dunia kerja dan untuk menguasai kosa kata yang berkaitan dengan jurusan mereka dalam dunia kerja; pada kasus ini yang dimaksud adalah mahasiswa jurusan teknik informatika di STIMIKOM Stella Maris Sumba. Dalam penelitian ini metode kualitatif adalah metode yang digunakan dan data-data diperoleh melalui wawancara dan observasi. Para pelajar menyadari bahwa bahasa Inggris selalu berdampingan dengan jurusan yang mereka tempuh, seperti untuk menguasai bahasa program, untuk mencari pekerjaan yang terutama mengutamakan kemampuan berbahasa Inggris dan untuk meningkatkan kemampuan dalam pengetahuan informasi dan komunikasi teknologi.. Selain tiga alasan di atas, mahasiswa juga ingin meningkatkan kemampuan berbicara dan membaca mereka. Dua kemampuan ini sangat bermanfaat untuk menyiapka diri mereka dalam memasuki dunia kerja dan membangun hubungan dengan banyak orang.
Kata kunci: Bahasa Inggris untuk tujuan Khusus, teknik informatika
DEVELOPING LEARNING MODULE AS SUPPLEMENTARY TEACHING MATERIAL FOR LEARNING ENGLISH
Authors: Rahmia Rafiqa Yusrin 
Published: August 2023

Rahmia, Rafiqa Yusrin. 2022. Developing Learning Module As Supplementary Teaching Material for Learning English for the fifth Graders of SD Negeri 4 Ternyang. English Education Department. Graduate Program. IKIP Budi Utomo of Malang, Advisor; Jasuli. S.Pd., M.Pd.

The background of developing teaching materials for the 5th grade English module at SD Negeri 4 Ternyang is by looking at the existing problems through interviewing English teachers and distributing questionnaires to 24 students. Interviews were used to analyze problems in the learning process, while questionnaires were used to analyze students' needs in learning English. Then the second questionnaire was used to collect data from material experts and media experts about the feasibility of the product being developed. The research was conducted due to the lack of learning media to distribute learning materials based on English teacher interviews
The objective of this study was to find out the which teaching materials are suitable for learning English grade 5 of SD Negeri 4 Ternyang. This study uses a research and development approach (Research and Development). The development procedure follows the Borg and Gall procedure which can be done more simply by involving 6 main steps, namely: 1) Research and data collection 2) Planning 3) Product development 4) Expert validation 5) Revision 6) Revised product.
The results of the assessment of the material expert test obtained a score of 77% in the good category, the assessment results from the media expert test obtained a score of 86% in the very good category. Therefore the teaching materials for the English learning module in grade 5 are suitable for use in learning activities.
Regarding the further development of learning module as supplementary teaching materials for learning English for elementary school grade 5 about the further development of learning modules as complementary teaching materials for learning English for grade 5 elementary school can be suggested to further researchers such as students who want to do similar research are expected to master technology, especially computers and expand the material, develop products at different grade levels, the product resulting from this research will be better and more feasible as a learning resource if it is tested on students in the learning process so that data is obtained in the form of values in order to determine the level of student learning abilities.

Keywords: learning module, English
Tindak Tutur Ilokusi dalam Kolom Komentar Akun Instagram @sathadcovif-19.id
Authors: Fatima Siti fatima Fatima , Sumarti Endang , Surahman Harry 
Published: August 2023

Abstrak Penelitian ini bertujuan mendeskripsikan bentuk dan fungsi tindak tutur ilokusi dalam akun instgaram @satgascovid-19.id. Data penelitian berupa kata, frasa dan kalimat tentang bentuk dan fungsi tindak tutur ilokusi dalam kolom komentar akun instagram @satgascovid-19.id. Sumber data dalam penelitian ini berupa kalimat/kata dan gambar dalam akun instagram @satgascivid-19.id. Instrument Penelitian ini adalah peneliti sendiri yang bersifat deskripsi kualitatif. Teknik pengumpulan data berupa menyimak, memahami, mencatat, mengelompok, Analisisi kalimat dan hasil identifikasi akun instagram @satgascovid-19.id yang dijadikan sebagai laporan penelitian. Teknis analisis data berupa Reduksi data, sajian data, dan penarikan kesimpulan. Tahap penelitian berupa tahap persiapan penelitian, tahap pelaksanaan penelitian, dan tahap penyelesaian.
Kata Kunci : tindak tutur, ilokusi dan akun instagram @satgascovid-19.id
AbstractThis study aims to describe the form and function of illocutionary speech acts in the @satgascovid-19id instagram account. Research data in the form of words, phrases and sentences about the form and function of illocutionary speech acts in the comments column of the Instagram account @satgascovid-19.id. The data sources in this study are sentences/words and pictures in the @satgascivid-19id instagram account. The instrument of this research is the researcher himself who has a qualitative description. Data collection techniques include listening, understanding, taking notes, grouping, analyzing sentences and identifying the results of the @satgascovid-19id instagram account which is used as a research report. Technical data analysis in the form of data reduction, data presentation, and drawing conclusions. The research stage is the research preparation stage, the research implementation stage, and the completion stage.Keywords: speech acts, illocutionary and instagram account @satgascovid-19.id
Meningkatkan kemampuan berbicara melalui metode role playing pada siswa kelas v SD negeri 1 petungsewu
Authors: Prasanti Widi Okta 
Published: August 2023

AbstrackPrasanti, Dwi Widi Oktarina. 2022. Application of the Role Playing Learning Model to Improve Indonesian Language Learning Outcomes for Fifth Grade Students of SD Negeri 1 Petungsewu. This study aims to determine the improvement of Indonesian language learning outcomes with the Role Playing learning model for fifth grade students of SD Negeri 1 Petungsewu. The following research is classroom action research (CAR). This classroom action research was carried out in two cycles of meetings, each cycle consisting of four stages, namely the first is the planning stage, the second is the implementation stage, the third is the observation stage and the fourth is the reflection stage. Each cycle in cycle I and cycle II was carried out three times in each cycle. The research was carried out in the fifth grade of SD Negeri 1 Petungsewu for the academic year 2021/2022. The data in this study were obtained through observation and test methods. The data analyzed in this study used the method of data obtained and analyzed by descriptive statistics.
Keywords: Learning, playing drama, role playing.
Synthesis of vancomycin functionalized fluorescent gold nanoparticles and selective sensing of mercury (II)
Authors: Tiwari Atul Kumar , Yadav Hari Prakash , Gupta Munesh Kumar , Narayan Roger J. , Pandey Prem C. 
Published: August 2023

Mercury ions (Hg2+) are widely found in the environment; it is considered a major pollutant. Therefore, the rapid and reliable detection of Hg2+ is of great technical interest. In this study, a highly fluorescent, sensitive, and selective fluorometric assay for detecting Hg2+ ions was developed using vancomycin functionalized and polyethyleneimine stabilized gold nanoparticles (PEI-f-AuNPs@Van). The as-made gold nanoparticles were highly fluorescent, with excitation and emission maxima occurring at 320 and 418 nm, respectively. The size of nanoparticles was ~7 nm; a zeta potential of ~38.8 mV was determined. The XRD analysis confirmed that the nanoparticles possessed crystalline structure with face centerd cubic symmetry. Using the PEI-f-AuNP@Van probe, the detection limit of Hg2+ ion was achieved up to 0.988 nM (within a linear range) by calculating the KSV. However, the detection limit in a natural environmental sample was shown to be 12.5 nM. Furthermore, the selectivity tests confirmed that the designed probe was highly selective to mercury (II) cations among tested other divalent cations. Owing to its sensitivity and selectivity, this approach for Hg2+ ions detection can be utilized for the analysis of real water samples.
Cfa-circ002203 was upregulated in rapidly paced atria of dogs and involved in the mechanisms of atrial fibrosis
Authors: Shangguan Wenfeng , Gu Tianshu , Cheng Rukun , Liu Xing , Liu Yu , Miao Shuai , Wang Weiding , Song Fang , Wang Hualing , Liu Tong , Liang Xue 
Published: August 2023

Background and aimsThe role of circular RNAs (circRNAs) in the pathophysiology of cardiovascular disease is gradually being elucidated; however, their roles in atrial fibrillation (AF)-related fibrosis are largely unknown. This study aimed to characterize the different circRNA profiles in the rapid-pacing atria of dogs and explore the mechanisms involved in atrial fibrosis.MethodsA rapid right atrial-pacing model was established using electrical stimulation from a pacemaker. After 14 days, atrial tissue was collected for circRNA sequencing analysis. In vitro fibrosis was established by stimulating canine atrial fibroblasts with angiotensin II (Ang II). The fibroblasts were transfected with siRNA and overexpressing plasmids to explore the effects of cfa-circ002203 on fibroblast proliferation, migration, differentiation, and the expression of fibrosis-related proteins.ResultsIn total, 146 differentially expressed circRNAs were screened, of which 106 were upregulated and 40 were downregulated. qRT-PCR analysis showed that cfa-circ002203 was upregulated in both in vivo and in vitro fibroblast fibrosis models. The upregulation of cfa-circ002203 enhanced proliferation and migration while weakening the apoptosis of fibroblasts. Western blotting showed that cfa-circ002203 overexpression increased the protein expression levels of fibrosis-related indicators (Col I, Col III, MMP2, MMP9, and α-SMA) and decreased the protein expression levels of pro-apoptotic factors (Bax and Caspase 3) in Ang II-induced fibroblast fibrosis.ConclusionCfa-circ002203 might serve as an active promoter of the proliferation, migration, and fibrosis of atrial fibroblasts and is involved in AF-induced fibroblast fibrosis.
Prairie Protector: student development of systems thinking habits in the context of agroecosystems
Authors: Ingram Erin , Keshwani Jenny 
Published: August 2023

IntroductionThe Great Plains ecosystem offers an opportunity for young people to gain knowledge about intricate systems through practical learning. The spread of woody plants into grasslands, known as the “Green Glacier,” poses a risk to biodiversity and animal production. Although effective management strategies exist, some land managers are reluctant to use them. It is critical to cultivate a scientifically literate population that can think systematically and make informed decisions based on STEM principles to address such complex agroecosystem problems.MethodsIn this study, semi-structured focus group discussions with high school students were analyzed to determine whether Prairie Protector, an educational game, and its associated resources led to evidence of systems thinking habits in student conversation.ResultsAnalysis of the focus group transcripts revealed that the students developed systems thinking habits through their experience playing Prairie Protector while developing empathy for land managers and others involved in the Great Plains agroecosystem. In general, students found the game enjoyable and a useful tool for learning about agroecosystems, conservation land management, and the spread of invasive species.DiscussionAnalysis of the student statements led to the development of a guiding framework to assess and analyze students development of systems thinking habits that could be used to scaffold student learning experiences to explore, understand, and interact with complex systems. Providing simulated environments for students to interact with complex systems should be explored in additional scenarios to support student development of systems thinking skills.
Cross-cultural adaptation and validation of the family needs assessment scale for Brazilian families of children and adolescents with disabilities
Authors: Nunes Ana Célia , Santos Daniela Bitencourt , Leite Márcio Fernandes Alves , Gràcia Marta , de Souza Della Barba Patricia Carla 
Published: August 2023

IntroductionIn Brazil, there are few studies that investigate the support needs of families that have handicap children in their daily context. This study aims to adapt and validate the Family Needs Assessment (FNA) scale for use with families of children and adolescents with disabilities in Brazil.MethodTwo studies were conducted. The first study involved the cross-cultural adaptation of the scale, resulting in the Brazilian version of the FNA, which is called Avaliação das Necessidades da Família (ANF). The FNA comprises 49 items with high internal consistency (α = 0.98). The second study validated the FNA using a sample of 151 families with children and adolescents with disabilities.ResultsThe structure of the scale was confirmed using Structural Equation Modeling (SEM), which grouped 46 items into seven dimensions. The scale demonstrated good fit (RMSEA = 0.041, SRMR = 0.063), satisfactory convergent validity (rs = −0.27, p &lt; 0.001), and high levels of reliability (α = 0.92, ω = 0.94) and test–retest consistency (R1F = 0.98).DiscussionThe FNA is a valid, reliable, and accurate measure for assessing the needs of Brazilian families with children and adolescents with disabilities under 18 years of age.
KLK2 single-nucleotide polymorphism rs198977 is associated with increased susceptibility and hyperleukocytosis in AML
Authors: Meng Guangqiang , Li Peng , Li Mingying , Wu Yuyan , Ma Yuechan , Sun Tao , Ji Chunyan 
Published: August 2023

Introduction: Acute myeloid leukemia (AML) is a heterogeneous myeloid malignancy with abnormal molecular diversity. Tissue kallikrein 2 (KLK2) is a kind of serine protease, and has a close relationship with the occurrence and development of malignant tumors. Single nucleotide polymorphism (SNP) of various genes are associated with susceptibility, treatment and survival of AML.Methods: We investigated the association of KLK2 SNPs rs198977 and rs2664155 with AML. We recruited 284 AML patients and 280 healthy controls from the Han population and genotyping KLK2 SNPs rs198977 and rs2664155 by MassARRAY system.Results: Using clinical data from AML patients and controls, including AML susceptibility, blood count, risk stratification, response to induced chemotherapy and survival, our results showed an increased risk of AML susceptibility with KLK2 rs198977 TT genotype in the recessive model. Regarding white blood cell counts in AML patients, the results showed an increased risk of hyperleukocytosis with the TT genotype of KLK2 rs198977 in a codominant model. Moreover, in the recessive model, AML with KLK2 SNPs rs198977 TT genotype had an increased risk of hyperleukocytosis. No significant correlation was found between KLK2 rs2664155 and AML.Discussion: This study suggests that KLK2 rs198977 may be an important genetic factor in the occurrence of AML and hyperleukocytosis in AML, providing a new perspective for disease progression and new therapeutic targets.
Cryptogenic chronic hepatitis: looking for an ideal diagnostic algorithm
Authors: Cançado Guilherme Grossi Lopes , Candolo Aline Coelho Rocha , Nardelli Mateus Jorge , Zitelli Patricia Momoyo , Mazo Daniel Ferraz de Campos , Oliveira Claudia Pinto , Cunha-Silva Marlone , Greca Raquel Dias , Araújo Roberta Chaves , Alustau Amanda Sacha Paulino Tolentino , Couto Cláudia Alves , Roque Gabriel Rezende de Lima , Farias Alberto Queiroz , Carrilho Flair José , Pessôa Mário Guimarães 
Published: August 2023

IntroductionCryptogenic chronic hepatitis is a growing cause of liver transplants, affecting 5%–15% of patients with chronic liver diseases. This study aimed to identify underlying causes of cryptogenic liver disease in a Brazilian cohort and propose a new diagnostic algorithm, including investigation for metabolic-dysfunction-associated fatty liver disease (MAFLD) and lysosomal acid lipase deficiency (LAL-D).MethodsA retrospective analysis was conducted on 326 patients with presumed cryptogenic hepatitis.ResultsUsing Czaja’s algorithm, non-alcoholic fatty liver disease was diagnosed in 21.3% of patients, while alpha-1 antitrypsin deficiency, alcoholic liver disease, autoimmune hepatitis, hemochromatosis, biliary-related hepatitis, viral hepatitis, Budd–Chiari syndrome, glycogenosis, drug-induced liver injury, and Wilson’s disease were diagnosed in smaller proportions (&lt; 3.5% each). LAL-D was found in 1% of patients, and 53.6% of patients remained with cryptogenic hepatitis. The etiology of the liver disease in a subset of patients undergoing liver transplantation was updated post hoc based on explant histology, and non-alcoholic steatohepatitis was found in 52.5% of patients. By incorporating the concept of MAFLD, the new algorithm could diagnose 49.1% of patients, reducing the number of individuals without an etiological diagnosis by 11.4%.ConclusionOne-third of patients with initially presumed cryptogenic liver disease were diagnosed with MAFLD. LAL-D should be considered in patients with chronic liver disease of unknown etiology. The updated diagnostic algorithm proposed in this study could improve diagnostic accuracy and aid in the management of patients with cryptogenic hepatitis.
NO–IL-6/10–IL-1β axis: a new pathway in steatotic and non-steatotic liver grafts from brain-dead donor rats
Authors: Casillas-Ramírez Araní , Micó-Carnero Marc , Sánchez-González Alfredo , Maroto-Serrat Cristina , Trostchansky Andrés , Peralta Carmen 
Published: August 2023

IntroductionBrain death (BD) and steatosis are both risk factors for organ dysfunction or failure in liver transplantation (LT)Material and methodsHere, we examine the role of interleukin 6 (IL- 6) and IL-10 in LT of both non-steatotic and steatotic liver recovered from donors after brain death (DBDs), as well as the molecular signaling pathways underlying the effects of such cytokines.ResultsBD reduced IL-6 levels only in nonsteatotic grafts, and diminished IL-10 levels only in steatotic ones. In both graft types, BD increased IL-1β, which was associated with hepatic inflammation and damage. IL-6 administration reduced IL-1β only in non-steatotic grafts and protected them against damage and inflammation. Concordantly, IL-1β inhibition via treatment with an IL-1 receptor antagonist caused the same benefits in non-steatotic grafts. Treatment with IL-10 decreased IL-1β only in steatotic grafts and reduced injury and inflammation specifically in this graft type. Blockading the IL-1β effects also reduced damage and inflammation in steatotic grafts. Also, blockade of IL-1β action diminished hepatic cAMP in both types of livers, and this was associated with a reduction in liver injury and inflammation, then pointing to IL-1β regulating cAMP generation under LT and BD conditions. Additionally, the involvement of nitric oxide (NO) in the effects of interleukins was evaluated. Pharmacological inhibition of NO in LT from DBDs prompted even more evident reductions of IL-6 or IL-10 in non-steatotic and steatotic grafts, respectively. This exacerbated the already high levels of IL-1β seen in LT from DBDs, causing worse damage and inflammation in both graft types. The administration of NO donors to non-steatotic grafts potentiated the beneficial effects of endogenous NO, since it increased IL-6 levels, and reduced IL-1β, inflammation, and damage. However, treatment with NO donors in steatotic grafts did not modify IL-10 or IL-1β levels, but induced more injurious effects tan the induction of BD alone, characterized by increased nitrotyrosine, lipid peroxidation, inflammation, and hepatic damage.ConclusionOur study thus highlights the specificity of new signaling pathways in LT from DBDs: NO–IL-6–IL-1β in non-steatotic livers and NO–IL-10–IL-1β in steatotic ones. This opens up new therapeutic targets that could be useful in clinical LT.
Regulatory T cells targeting a pathogenic MHC class II: Insulin peptide epitope postpone spontaneous autoimmune diabetes
Authors: Obarorakpor Nyerhovwo , Patel Deep , Boyarov Reni , Amarsaikhan Nansalmaa , Cepeda Joseph Ray , Eastes Doreen , Robertson Sylvia , Johnson Travis , Yang Kai , Tang Qizhi , Zhang Li 
Published: August 2023

IntroductionIn spontaneous type 1 diabetes (T1D) non-obese diabetic (NOD) mice, the insulin B chain peptide 9-23 (B:9-23) can bind to the MHC class II molecule (IAg7) in register 3 (R3), creating a bimolecular IAg7/InsulinB:9-23 register 3 conformational epitope (InsB:R3). Previously, we showed that the InsB:R3-specific chimeric antigen receptor (CAR), constructed using an InsB:R3-monoclonal antibody, could guide CAR-expressing CD8 T cells to migrate to the islets and pancreatic lymph nodes. Regulatory T cells (Tregs) specific for an islet antigen can broadly suppress various pathogenic immune cells in the islets and effectively halt the progression of islet destruction. Therefore, we hypothesized that InsB:R3 specific Tregs would suppress autoimmune reactivity in islets and efficiently protect against T1D.MethodsTo test our hypothesis, we produced InsB:R3-Tregs and tested their disease-protective effects in spontaneous T1D NOD.CD28-/- mice.ResultsInsB:R3-CAR expressing Tregs secrete IL-10 dominated cytokines upon engagement with InsB:R3 antigens. A single infusion of InsB:R3 Tregs delayed the onset of T1D in 95% of treated mice, with 35% maintaining euglycemia for two healthy lifespans, readily home to the relevant target whereas control Tregs did not. Our data demonstrate that Tregs specific for MHC class II: Insulin peptide epitope (MHCII/Insulin) protect mice against T1D more efficiently than polyclonal Tregs lacking islet antigen specificity, suggesting that the MHC II/insulin-specific Treg approach is a promising immune therapy for safely preventing T1D.