bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the method of providing fuel economy of trucks by means of intelligent transport systems
Authors: Gritsuk Igor , Volkov Volodymyr , Ukrainskyi Eugene , Volkova Tetiana , Kuzhel Volodymyr 
Published: September 2023

The purpose of the study is improving the method of ensuring the fuel efficiency of trucks by means of intelligent transport systems in variable operating conditions. The analysis of the processes of ensuring the operational control of the fuel consumption of cargo vehicles shows the perspective of their implementation on the basis of modern intelligent transport systems, the main tool of which is the method of remote monitoring. Remote monitoring of cargo vehicles is an effective tool designed not only for tracking the location and movement of vehicles, but also for a certain number of parameters of their technical condition. A mathematical model of an improved method of ensuring the fuel economy of trucks has been developed, which includes a process and analytical component for estimating limit values, forming optimal characteristics and forecasting technical condition parameters and fuel consumption by the engine and vehicle in the processes of cargo transportation. The mathematical model is built on the basis of differential and algebraic equations developed at KhNADU (Kharkiv National Automobile and Road University), NTU (National Transport University) and personally by the authors, which was adapted with appropriate changes in the part of the initial data and algebraic equations to improve the existing method. The improved method for determining and calculating the fuel consumption of a vehicle in operating conditions is based on the information and software complex (ISK) "Virtual Mechanic "HADI-12"" and the ISK "Service Fuel Eco "NTU-HADI-12"" of Khnadu.
As a result, the authors formulated as a general approach to the formation and improvement of the method of ensuring the fuel economy of a cargo vehicle of category N3 in the conditions of operation by means of intelligent transport systems, and actually the processes of solving the set tasks are based on the implementation of the system interaction of three interrelated components: process, information and analytical.
Methods of specifying the speed measurement of a car on the road during diagnostics
Authors: Zybtsev Yuriy , Kashkanov Vitaly , Vishtak Inna , Voroshylov Pavlo 
Published: September 2023

This article describes methods of calibrating car speedometer on the road without expensive equipment. The most accurate results are obtained by using marking elements, for instance, the standard road guard fence. The most practical method is synchronous video recording of speedometer and the display of receiver for satellite signals GPS or/and GLONASS. Also, the Khnadu has substantiated methods of checking a car for acceleration and running out onto the road with simple measuring devices - a speedometer and a phone stopwatch.
Experiments have shown that the real picture of countermeasures does not fit into generally accepted models, and this should be taken into account when calculating the standards of diagnostic parameters - the path and time of exit and acceleration. For check of the car by a known method the horizontal section of the road 2.5...3 km long is necessary. On the most part of the territory of Ukraine such sections are very rare, so it is proposed to check up a car on an acceleration on II and III gears and on a coasting down from 50 or 40 km/h to 20 km/h, using accessible length of 0,5 km.
Behavior of car in such conditions was studied, some unknown specificities are discovered and described. The methods of calculation of control values for time of acceleration and time of coasting are offered. The speedometer is a frequency converter of the output shaft of the transmission or the wheels of the car. It inevitably reflects all the errors caused by the uncertainty of the rolling radius of the wheel, including due to atmospheric conditions, the degree of tire warm-up, vehicle loading and its distribution in the longitudinal and transverse directions, etc. Under these conditions, it is necessary to improve the standless diagnostic methods available to ordinary drivers, i.e. on-the-road inspection methods without complicated or prohibitively expensive equipment. So the calibration of the speedometer is a necessary test step and, in critical cases, must be performed at the beginning and end of each test day. Experimentally estimated the error, the required duration of measurement and speed variation when maintaining it by driver or by cruise control. Grading on GPS better when driving south. Calibration equation was obtained for the 2006 Honda Civic: VGPS = 0,9528 Vspeedo. – 0,83.
Differential Association of Dietary Linoleic Acid and Alpha-linolenic Acid with Adipose Tissue in a Sample of Iranian Adults; A Cohort-based Cross-sectional Study
Authors: Masoumi Seyed Jalil , Mohit Mohsen , Karami Esmail , Hadi Saeid 
Published: September 2023

Background: Overweight and obesity are the most critical risk factors for chronic diseases. The quality of dietary fatty acids as one of the factors affecting fat accumulation has received little attention. This study investigates the association between dietary linoleic acid (LA) and alpha-linolenic acid (ALA) with body fat indices in a sample of healthy Iranian adults.Materials and Methods: In this cohort-based cross-sectional study, 3,195 individuals aged 20 to 60 who participated in the Shiraz University of Medical Science Employees Health Cohort study were included. Dietary intake was assessed using a validated 118-item Food Frequency Questionnaire (FFQ), and body composition was assessed by the bioelectrical impedance analysis method. Multiple linear regression adjusted for relevant confounders was used to determine the associations.Results: Mean dietary intake of LA was 14.20 Â± 7.01 mg/day for men and 13.90 Â± 6.71 mg/day for women. Additionally, the daily intake of ALA was 0.18 Â± 0.18 mg/day in men and 0.17 Â± 0.19 mg/day in women. Dietary intake of ALA for men had an inversely significant association with body fat mass (BFM) (Î²: -0.585, 95% CI: -1.137, -0.032, P=0.038), percentage of body fat (PBF) (Î²: -0.537, 95% CI: -0.945, -0.129, P=0.010), Visceral Fat Area (VFA) (Î²: -2.998, 95% CI: -5.695, -0.302, P=0.029), and Waist to Hip Ratio (WHR) (Î²: -0.689, 95% CI: -1.339, -0.040, P=0.038).Conclusion: Higher dietary ALA intake was associated with lower BFM, BFP, VAF, and WHR in men. The present study confirms that ALA intake should be considered a preventive treatment to improve body composition. However, further research is recommended in this regard.
COMPARAÇÃO DO NÍVEL DE ATIVIDADE FÍSICA DIÁRIA E CONHECIMENTO SOBRE A DOENÇA PULMONAR OBSTRUTIVA CRÔNICA ENTRE HOMENS E MULHERES
Authors: Albuquerque Sampaio Juliana Albuquerque , Garcia Rejanny Duque Thomaz , Rabahi Marcelo Fouad , Corrêa Krislainy De Sousa 
Published: September 2023

A DPOC tem a inatividade física como um fator de piora da condição física. Nota-se a importância do conhecimento sobre a doença para que os doentes consigam um automanejo adequado e alcancem melhor qualidade de vida. O objetivo é comparar o nível de atividade física e o conhecimento da doença entre homens e mulheres com DPOC. Trata-se de um estudo transversal analítico, realizado em uma clínica de pneumologia em Goiânia-GO. Aplicou-se o questionário de Bristol para avaliar o grau de conhecimento sobre a DPOC e o pedômetro para avaliar o nível de atividade física diária. Contou com 38 homens e 32 mulheres, ambos os sexos apresentaram-se em sua maioria (60,5% vs 59,4%) como severamente inativo, porém nenhuma mulher foi classificada como ativa, enquanto 23,7% dos homens receberam essa classificação. Sobre o conhecimento da DPOC, não houve diferença entre homens e mulheres (p>0,05), eles sabem mais sobre os sintomas (3,45 ±1,06 vs 3,37± 1,16) e a etiologia (3,58± 0,95 vs 3,59 ±1,10) e sabem menos sobre os medicamentos: broncodilatador inalado (0,71± 1,04 vs 1,03± 1,00) e corticoide inalado (0,39 ± 0,68 vs 0,53± 0,88). Conclui-se que não houve diferença estatística entre homens e mulheres quanto ao nível de atividade física e quanto ao conhecimento sobre a doença.
VII CONGRESSO BRASILEIRO DE FISIOTERAPIA NEUROFUNCIONAL, III CONGRESSO INTERNACIONAL DA ASSOCIAÇÃO BRASILEIRA DE FISIOTERAPIA NEUROFUNCIONAL E II SIMPÓSIO INTERNACIONAL DE SAÚDE FUNCIONAL
Authors: Organizadora Comissão 
Published: September 2023

Com o tema “Promovendo a funcionalidade centrada na pessoa e na família”, o VII Congresso Brasileiro de Fisioterapia Neurofuncional (COBRAFIN) recebeu em Fortaleza (CE) cerca 1000 participantes, entre fisioterapeutas, pesquisadores, acadêmicos, pacientes e familiares, que se reuniram para partilhar conhecimento e discutir sobre a funcionalidade humana nos diversos ciclos da vida.
A programação científica contou com a ilustre presença de palestrantes de renome nacional e internacional que abordaram temas atuais e, de extrema relevância cientifica e para aplicação da prática clínica, com um ciclo de 90 palestras, distribuídas nos três dias de congresso, além da apresentação de mais de 400 trabalhos científicos aprovados, entre pôsteres e temas livres.
Para nós, que escolhemos trabalhar com a Fisioterapia Neurofuncional, embasar nossa prática clínica nas evidências científicas deve ser uma rotina exercida com responsabilidade e dedicação profissional. O COBRAFIN foi uma amostra de como a Fisioterapia Neurofuncional brasileira evoluiu e está aperfeiçoando suas práticas a cada dia. O evento também foi uma oportunidade de trocas de conhecimento testemunhando o fortalecimento da nossa especialidade, trazendo grandes discussões sobre os temas que contribuem para o aprimoramento da área.
Agradecemos ao corpo editorial da Revista Movimenta pela oportunidade de deixar este legado científico do VII COBRAFIN. A Fisioterapia Neurofuncional Brasileira continua escrevendo a sua história com muito trabalho, ciência e dedicação.
„Ozdobiona wszelkimi cnotami” cesarska siostra Pulcheria i „roztropna” cesarzowa Atenais-Eudocja – co o epoce Teodozjusza II wiedzieli Słowianie prawosławni w średniowieczu?
Authors: Brzozowska Zofia , Leszka Mirosław J. 
Published: September 2023

Obraz cesarstwa bizantyńskiego w połowie V w. i wizerunek władających nim osób w piśmiennictwie staroruskim ukształtował się na bazie stworzonych na Bałkanach przekładów cerkiewnosłowiańskich dzieł trzech historyków bizantyńskich: Jana Malalasa (VI w.), Jerzego Mnicha zw. Hamartolosem (IX w.) i Konstantyna Manassesa (XII w.). Wykorzystywanie ich przekazów przez autorów chronografów nawet w drugiej połowie XVI w. świadczy o wyjątkowej żywotności historiografii bizantyńskiej i swoistej ponadczasowości utworów wspomnianych dziejopisów. Trzeba jednak zauważyć, iż Pulcheria, Teodozjusz II, Atenais-Eudocja i Marcjan nie przykuwali uwagi staroruskich historiografów tylko jako osoby mające realny wpływ na bieg wydarzeń w przeszłości. Słowianie prawosławni schyłku średniowiecza postrzegali połowę V w. przede wszystkim jako epokę wielkich sporów o naturę Chrystusa, zakończonych zwołaniem soborów ekumenicznych w Efezie (431 r.) i Chalcedonie (451 r.). Niektórzy zaangażowani w kontrowersje teologiczne swego czasu cesarze i cesarzowe byli na obszarze Slavia Orthodoxa czczeni jako święci. Analiza staroruskich chronografów z XIV–XVI w. pozwala przypuścić, że hagiografia oddziaływała na kreowanie wizerunków tego rodzaju postaci w historiografii. By zrekonstruować całościowy obraz Pulcherii i Atenais-Eudocji w literaturze staroruskiej należałoby zatem przebadać też poświęcone im teksty hagiograficzne.
A Social Network Analysis of Interagency Collaboration in the Mental Health Sector in Toronto, Canada: Service Providers’ Perspectives on Supporting Black Youth in Recovery
Authors: Booker Melissa , Jackson-Best Fatimah , Fante-Coleman Tiyondah 
Published: September 2023

Objective: There is minimal research on mental health service providers’ perspectives on existing interagency relationships, collaboration, and caring for Black youth. We sought to characterize interagency relationships between Mainstream and Black-focused mental health agencies in Ontario, and their impact on service providers’ ability to provide culturally safe care for Black youth.
Research Design and Methods: A mixed methodological approach was used to explore service providers’ perspectives on the collaborative nature and presence of relationships, communication, and influence in the mental health sector. An online survey was disseminated to service providers in Toronto, Ontario between March 2020 and April 2020. 7 focus groups were conducted in Toronto between May 2020 and December 2020. Focus groups were conducted with Black youth, families/caregivers, community, and service providers. Quantitative data were analyzed using SPSS and visualized in the form of social network analysis using Gephi, while Nvivo 12 was utilized to identify and analyze themes from the qualitative data.
Results: Findings included a lack of interagency collaboration, infrequent Mainstream-Black agency collaborations, Mainstream agencies’ disinterest in future partnerships with Black agencies, and feelings of unpreparedness amongst service providers to provide culturally safe care to Black youth or referrals.
Conclusions: Collaboration between mainstream agencies is common in the sector. There is a paucity of Black-focused agencies and Black service providers in the existing social networks. A limited understanding of the systemic impacts anti-Black racism at the agency and service provider level might be impairing service providers’ ability to support the mental health recovery of Black youth.
Preparation of PLGA microspheres loaded with niclosamide via microfluidic technology and their inhibition of Caco-2 cell activity in vitro
Authors: Tai Yulei , Tian Menglun , Chen Yu , You Peijun , Song Xiaojun , Xu Bangting , Duan Cidong , Jin Dazhi 
Published: September 2023

Niclosamide (NIC) is a multifunctional drug that regulates various signaling pathways and biological processes. It is widely used for the treatment of cancer, viral infections, and metabolic disorders. However, its low water solubility limits its efficacy. In this study, poly(lactic-co-glycolic acid) (PLGA) and hyaluronic acid (HA), which exhibit good biocompatibility, biodegradability, and non-immunogenicity, were conjugated with niclosamide to prepare PLGA-HA-niclosamide polymeric nanoparticles (NIC@PLGA-HA) using microfluidic technology. The obtained microspheres had a uniform size distribution, with an average mean size of 442.0 ± 18.8 nm and zeta potential of −25.4 ± 0.41 mV, indicating their stable dispersion in water. The drug-loading efficiency was 8.70%. The drug-loaded microspheres showed sustained release behavior at pH 7.4 and 5.0, but not at pH 2.0, and the drug release kinetics were described by a quasi-first-order kinetic equation. The effect of the drug-loaded microspheres on the proliferation of Caco-2 cells was detected using the MTT assay. Hydrophilic HA-modified NIC@PLGA-HA microspheres prepared via microfluidic technology increased the cellular uptake by Caco-2 cells. Compared to the same concentration of NIC, the NIC@PLGA-HA microspheres demonstrated a stronger inhibitory effect on Caco-2 cells owing to the combined effect of PLGA, HA, and NIC. Therefore, the pH-responsive NIC@PLGA-HA microspheres synthesized using microfluid technology increased the solubility of NIC and improved its biological activity, thus contributing to the demand for intestinal drug carriers.
Revalidation of the ATTRACTION-4 study in a real-world setting: a multicenter, retrospective propensity score matching study in China
Authors: Dai Yuhong , Liu Yongqing , Gong Zhimin , He Lilin , Wang Lei , Yang Wenjie , Qiu Ping , Zhang Fangyuan , Yuan Xianglin , Cheng Henghui , Qiu Hong 
Published: September 2023

BackgroundImmune-checkpoint inhibitors (ICIs) combined with chemotherapy have been successfully used in clinical trials to treat advanced gastric cancer. However, the efficacy and safety of first-line immunotherapy combined with chemotherapy in Chinese patients are unknown.MethodsThis multicenter retrospective study included patients with human epidermal growth factor receptor-2 (HER-2) negative advanced gastric cancer treated with first-line chemotherapy or chemotherapy with an ICI between January 2019 and December 2022. Propensity score matching was used to compare progression-free survival (PFS), overall survival, objective response rates, and adverse reactions between cohorts.ResultsAfter propensity score matching, 138 patients, who had balanced baseline characteristics, were included in the chemotherapy and combination treatment groups. The median follow-up duration was 16.90 months, and the median PFS was 8.53 months (95% confidence interval [CI] 7.77-9.28) in the combination treatment group and 5.97 months (95% CI 4.56-7.37) in the chemotherapy group. The median survival duration was 17.05 months (95% CI 14.18-19.92) in the combination treatment group and 16.46 months (95% CI 12.99-19.93) in the chemotherapy group. The PFS subgroup analysis revealed that age ≥65 years, women, Eastern Cooperative Oncology Group performance status of 1, non-signet ring cell carcinoma, esophagogastric junction, liver metastasis, peritoneal metastasis, no massive ascites, only one metastatic organ, and combined platinum-based chemotherapy correlated with treatment benefit. The incidences of adverse events above grade 3 were comparable between groups.ConclusionsOur study confirmed the ATTRACTION-4 trial results. Compared with chemotherapy, first-line ICIs combined with chemotherapy prolonged PFS but did not improve overall survival in patients with HER-2-negative advanced gastric cancer.
Development and validation of prognostic index based on purine metabolism genes in patients with bladder cancer
Authors: Wu Zixuan , Feng Ziqing , Wei Hongyan , Lin Chuying , Chen Ke 
Published: September 2023

BackgroundBladder cancer (BLCA) is a prevalent malignancy affecting the urinary system and is associated with significant morbidity and mortality worldwide. Dysregulation of tumor metabolic pathways is closely linked to the initiation and proliferation of BLCA. Tumor cells exhibit distinct metabolic activities compared to normal cells, and the purine metabolism pathway, responsible for providing essential components for DNA and RNA synthesis, is believed to play a crucial role. However, the precise involvement of Purine Metabolism Genes (PMGs) in the defense mechanism against BLCA remains elusive.MethodsThe integration of BLCA samples from the TCGA and GEO datasets facilitated the quantitative evaluation of PMGs, offering potential insights into their predictive capabilities. Leveraging the wealth of information encompassing mRNAsi, gene mutations, CNV, TMB, and clinical features within these datasets further enriched the analysis, augmenting its robustness and reliability. Through the utilization of Lasso regression, a prediction model was developed, enabling accurate prognostic assessments within the context of BLCA. Additionally, co-expression analysis shed light on the complex relationship between gene expression patterns and PMGs, unraveling their functional relevance and potential implications in BLCA.ResultsPMGs exhibited increased expression levels in the high-risk cohort of BLCA patients, even in the absence of other clinical indicators, suggesting their potential as prognostic markers. GSEA revealed enrichment of immunological and tumor-related pathways specifically in the high-risk group. Furthermore, notable differences were observed in immune function and m6a gene expression between the low- and high-risk groups. Several genes, including CLDN6, CES1, SOST, SPRR2A, MYBPH, CGB5, and KRT1, were found to potentially participate in the oncogenic processes underlying BLCA. Additionally, CRTAC1 was identified as potential tumor suppressor genes. Significant discrepancies in immunological function and m6a gene expression were observed between the two risk groups, further highlighting the distinct molecular characteristics associated with different prognostic outcomes. Notably, strong correlations were observed among the prognostic model, CNVs, SNPs, and drug sensitivity profiles.ConclusionPMGs have been implicated in the etiology and progression of bladder cancer (BLCA). Prognostic models corresponding to this malignancy aid in the accurate prediction of patient outcomes. Notably, exploring the potential therapeutic targets within the tumor microenvironment (TME) such as PMGs and immune cell infiltration holds promise for effective BLCA management, albeit necessitating further research. Moreover, the identification of a gene signature associated with purine Metabolism presents a credible and alternative approach for predicting BLCA, signifying a burgeoning avenue for targeted therapeutic investigations in the field of BLCA.
Plasma pentosidine as a useful biomarker of sarcopenia, low gait speed, and mortality in patients with cirrhosis
Authors: Saeki Chisato , Saito Mitsuru , Tsubota Akihito 
Published: September 2023

PurposeThe accumulation of advanced glycation end products (AGEs) is associated with various diseases and age-related impairments, including loss of muscle mass and function. We investigated the association between plasma pentosidine, which is one of the AGEs, and sarcopenia, low gait speed, and mortality in patients with cirrhosis.MethodsThis retrospective study divided 128 patients with cirrhosis into three groups by 25th and 75th quartiles of baseline plasma pentosidine levels: low (L)-, intermediate (I)-, and high (H)-pentosidine (Pen) groups. Sarcopenia was diagnosed following the Japan Society of Hepatology criteria. Low gait speed was defined as &lt;0.8 m/s. The cumulative survival rates were compared between the three groups. Cox proportional hazards regression analysis was performed to identify independent factors associated with mortality.ResultsOf the 128 patients, 40 (31.3%) and 34 (26.6%) had sarcopenia and low gait speed, respectively. The prevalence of sarcopenia and low gait speed significantly increased stepwise with increasing plasma pentosidine levels, with the highest in the H-Pen group (59.4% [19/32] and 56.3% [18/32], respectively) and lowest in the L-Pen group (18.8% [6/32] and 6.3% [2/32], respectively). Multivariate analysis identified plasma pentosidine levels as a significant and independent factor associated with sarcopenia (odds ratio [OR], 1.07; p = 0.036) and low gait speed (OR, 1.06; p = 0.036), with the cutoff levels of 0.0792 μg/mL (sensitivity/specificity, 0.600/0.773) and 0.0745 μg/mL (sensitivity/specificity, 0.735/0.691), respectively. The cumulative survival rates were significantly lower in the H-Pen group than in the L-Pen (hazard ratio [HR], 11.7; p = 0.001) and I-Pen (HR, 4.03; p &lt; 0.001) groups. Plasma pentosidine levels were identified as a significant and independent prognostic factor (HR, 1.07; p &lt; 0.001).ConclusionPlasma pentosidine levels are associated with sarcopenia, low gait speed, and mortality and may serve as a useful surrogate biomarker for these clinical events in patients with cirrhosis.