bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual stage approach to laser-driven helical coil proton acceleration
Authors: Ferguson S , Martin P , Ahmed H , Aktan E , Alanazi M , Cerchez M , Doria D , Green J S , Greenwood B , Odlozilik B , Willi O , Borghesi M , Kar S 
Published: January 2023

Abstract
Helical coil accelerators are a recent development in laser-driven ion production, acting on the intrinsically wide divergence and broadband energy spectrum of laser-accelerated protons to deliver ultra-low divergence and quasi-monoenergetic beams. The modularity of helical coil accelerators also provides the attractive prospective of multi-staging. Here we show, on a proof-of-principle basis, a two-stage configuration which allows optical tuning of the energy of the selected proton beamlet. Experimental data, corroborated by particle tracing simulations, highlights the importance of controlling precisely the beam injection. Efficient post-acceleration of the protons with an energy gain up to ∼16 MeV (∼8 MeV per stage, at an average rate of ∼1 GeV m−1) was achieved at an optimal time delay, which allows synchronisation of the selected protons with the accelerating longitudinal electric fields to be maintained through both stages.
Numerical simulation of vortex shedding from rectangular cylinders with different elongation ratios
Authors: Wu Jian , Liu Yakun , Zhang Di , Cao Ze , Li Zhuoyue 
Published: January 2023

Abstract
RANS simulations are performed for flow past rectangular cylinders with different elongation ratios (L/D= 1, 2, 4, 6, 8, 10, 12, 14 and 16) at Re= 22 000 using the k-ω SST turbulence model. As L/D increases from 1 to 6, stepwise increase of Strouhal number (St) exists, whereas an almost linear variation of St with respect to L/D can be found (St= 0.1618*L/D) at L/D⩾ 8. In the flow, two small secondary vortices beneath the shear layers are identified and the trailing-edge secondary vortex presents opposite rotational direction comparing with the leading-edge main vortex. Analysis of the shear layer and vortex characteristics is carried out to correlate with the wall normal stress and shear stress on the rectangular cylinder surfaces. Further, four coupling modes between leading-edge vortex (L-vortex) and trailing-edge vortex (T-vortex) among cylinders with different L/D are observed, named L-Vortex Mode (i.e. L/D= 1–2), L-T-Vortex Mode (i.e. L/D= 4–8), T-L-Vortex Mode (i.e. L/D= 10–14), and T-Vortex Mode (i.e. L/D ⩾ 16). When L/D > 4, the convective velocity of the L- and T-vortex is not sensitive to the L/D.
Automatic generation of Grover quantum oracles for arbitrary data structures
Authors: Seidel Raphael , Becker Colin Kai-Uwe , Bock Sebastian , Tcholtchev Nikolay , Gheorghe-Pop Ilie-Daniel , Hauswirth Manfred 
Published: January 2023

Abstract
The steadily growing research interest in quantum computing—together with the accompanying technological advances in the realization of quantum hardware—fuels the development of meaningful real-world applications, as well as implementations for well-known quantum algorithms. One of the most prominent examples till today is Grover’s algorithm, which can be used for efficient search in unstructured databases. Quantum oracles that are frequently masked as black boxes play an important role in Grover’s algorithm. Hence, the automatic generation of oracles is of paramount importance. Moreover, the automatic generation of the corresponding circuits for a Grover quantum oracle is deeply linked to the synthesis of reversible quantum logic, which—despite numerous advances in the field—still remains a challenge till today in terms of synthesizing efficient and scalable circuits for complex Boolean functions. In this paper, we present a flexible method for automatically encoding unstructured databases into oracles, which can then be efficiently searched with Grover’s algorithm. Furthermore, we develop a tailor-made method for quantum logic synthesis, which vastly improves circuit complexity over other current approaches. Finally, we present another logic synthesis method that considers the requirements of scaling onto real world backends. We compare our method with other approaches through evaluating the oracle generation for random databases and analyzing the resulting circuit complexities using various metrics.
Self-assembly of bioinspired peptides for biomimetic synthesis of advanced peptide-based nanomaterials: a mini-review
Authors: Kong Hao , Yang Guozheng , He Peng , Zhu Danzhu , Luan Xin , Xu Youyin , Mu Rongqiu , Wei Gang 
Published: January 2023

Abstract
The design and motif-tailoring of peptide sequences are crucial for mediating the self-assembly of peptide molecules and the biomimetic synthesis of functional peptide-based nanomaterials. It is well known that nature provides guidance and inspiration for the design and molecular tailoring of functional peptide sequences, which can further self-assemble into complex peptide nanomaterials with adjustable dimensions. In this mini-review, we summarize recent advances in the bioinspired design and regulation of functional peptide sequences by natural things, such as mussels, milk protein, silkworm silk, frogs and Alzheimer’s disease. The self-assembly of bioinspired peptides in vitro and in vivo for controlled synthesis of various peptide-based nanomaterials is introduced and analyzed. In addition, various applications of biomimetic peptide nanomaterials for biosensors, bioimaging, cancer therapy, antibacterial materials, tissue engineering, as well as energy storage and environmental science are demonstrated in detail. Finally, we give perspectives on the future development of this promising research topic. With these efforts, we hope to promote the understanding of the optimization of bioinspired peptides and the design of novel peptide nanomaterials for advanced applications.
Morphology exploration of pollen using deep learning latent space
Authors: Grant-Jacob James A , Zervas Michalis N , Mills Ben 
Published: January 2023

Abstract
The structure of pollen has evolved depending on its local environment, competition, and ecology. As pollen grains are generally of size 10–100 microns with nanometre-scale substructure, scanning electron microscopy is an important microscopy technique for imaging and analysis. Here, we use style transfer deep learning to allow exploration of latent w-space of scanning electron microscope images of pollen grains and show the potential for using this technique to understand evolutionary pathways and characteristic structural traits of pollen grains.
Antennal Sensilla in Longhorn Beetles (Coleoptera: Cerambycidae)
Authors: Haddad Stephanie , Clarke Dave J , Jeong Soo-Hyun , Mitchell Robert F , McKenna Duane D 
Published: January 2023

AbstractInsect antennae are crucial sensory organs that house numerous sensilla with receptors for perceiving a wide variety of cues dominating their world. Historically, inconsistent terminology and criteria have been used to classify antennal sensilla, which has greatly impeded the comparison of data even across closely related species. Longhorn beetles (Coleoptera: Cerambycidae) are no exception to this quandary, and despite their prominent antennae, few studies have investigated their antennal morphology and ultrastructure, and none have compared sensillar diversity and variation among cerambycids. Existing studies of longhorn beetle antennal sensilla include only 29 species in five of the eight cerambycid subfamilies and include misidentified sensilla types and conflicting terminology. As such, it is very difficult to conduct comparative morphological studies of antennal sensilla in longhorn beetles and challenging to understand inter- and intra-specific variation in the sensory systems of these beetles. To facilitate future comparative studies, we reviewed all accessible published papers that have used scanning and transmission electron microscopy (SEM and TEM) to investigate antennal sensilla in cerambycids, and present a first attempt at standardizing the classification of their documented sensilla types and subtypes. Specifically, we discuss seven major types of antennal sensilla (Böhm bristles, sensilla chaetica, chemosensory hairs, sensilla basiconica, dome shaped organs, sensilla coeloconica, and sensilla auricillica). We also imaged the antennae of relevant species of longhorn beetles using SEM and included images exemplifying as many of the sensilla types and subtypes as possible.
Evaluation of Stoffenmanager® and ART for Estimating Occupational Inhalation Exposures to Volatile Liquids
Authors: Lee Eun Gyung 
Published: January 2023

AbstractIn practice, workers often handle the same chemical(s) of interest under different control measures (e.g. local ventilation, enclosed system) during a full shift. Stoffenmanager® allows users to predict either task-based or full-shift exposures. However, most previous studies evaluated the tool by comparing task-based exposures with measured exposures. Also, limited evaluation studies of the Advanced REACH Tool (ART) with the Bayesian approach (ART+B) are available, requiring additional evaluation studies. The performance of Stoffenmanager® and ART with and without the Bayesian approach was evaluated with measured full-shift exposures to volatile liquids in terms of accuracy, precision, and conservatism. Forty-two exposure situation scenarios (including 251 exposures), developed based on job tasks and chemicals handled during tasks from workplaces, were used to generate full-shift estimates. The estimates were then compared with measured exposures using various comparison methods. Overall, Stoffenmanager® appeared to be the most accurate among the testing tools, while ART+B was the most precise. The percentage of measured exposures exceeding the tools’ 90th percentile estimates (%M&gt;T) demonstrated that Stoffenmanager® (16%M&gt;T) and ART+B (13%M&gt;T) were more conservative than ART (41%M&gt;T). When the 90% upper confidence limit of the 90th percentile estimate was considered, the level of conservatism changed from low (41%M&gt;T) to medium (17%M&gt;T) for ART and from medium (13%M&gt;T) to high (0.8%M&gt;T) for ART+B. The findings of this study indicate that no single tool would work for all ESs. Thus, it is recommended that users select a tool based on the performance results of three components (i.e. accuracy, precision, and conservatism), not depending on one or two components. The strength of this study is that the required tools’ input parameters were obtained during the sample collection to minimize assumptions for many input parameters. In addition, unlike other previous studies, multiple subtasks, which happen often in workplaces, were incorporated in this study. Nevertheless, the present study did not cover all activities listed in the tools and was limited to volatile liquids, suggesting further studies cover other exposure categories (e.g. solid, metal) and diverse activities.
Time-calibrated phylogenies reveal mediterranean and pre-mediterranean origin of the thermophilous vegetation of the Canary Islands
Authors: Martín-Hernanz Sara , Nogales Manuel , Valente Luis , Fernández-Mazuecos Mario , Pomeda-Gutiérrez Fernando , Cano Emilio , Marrero Patricia , Olesen Jens M , Heleno Ruben , Vargas Pablo 
Published: January 2023

AbstractBackground and AimsThe Canary Islands have strong floristic affinities with the Mediterranean Basin. One of the most characteristic and diverse vegetation belts of the archipelago is the thermophilous woodland (between 200 and 900 m.a.s.l.). This thermophilous plant community consists of many non-endemic species shared with the Mediterranean Floristic Region together with Canarian endemic species. Consequently, phytogeographic studies have historically proposed the hypothesis of an origin of the Canarian thermophilous species following the establishment of the summer-dry mediterranean climate in the Mediterranean Basin around 2.8 million years ago.MethodsTime-calibrated phylogenies for 39 plant groups including Canarian thermophilous species were primarily analysed to infer colonization times. In particular, we used 26 previously published phylogenies together with 13 new time-calibrated phylogenies (including newly generated plastid and nuclear DNA sequence data) to assess whether the time interval between stem and crown ages of Canarian thermophilous lineages postdates 2.8 Ma. For lineages postdating this time threshold, we additionally conducted ancestral area reconstructions to infer the potential source area for colonization.Key ResultsA total of 43 Canarian thermophilous lineages were identified from 39 plant groups. Both mediterranean (16) and pre-mediterranean (9) plant lineages were found. However, we failed to determine the temporal origin for 18 lineages because a stem–crown time interval overlaps with the 2.8-Ma threshold. The spatial origin of thermophilous lineages was also heterogeneous, including ancestral areas from the Mediterranean Basin (nine) and other regions (six).ConclusionsOur findings reveal an unexpectedly heterogeneous origin of the Canarian thermophilous species in terms of colonization times and mainland source areas. A substantial proportion of the lineages arrived in the Canaries before the summer-dry climate was established in the Mediterranean Basin. The complex temporal and geographic origin of Canarian thermophilous species challenges the view of the Canary Islands (and Madeira) as a subregion within the Mediterranean Floristic Region.
Isolation and characterization of blackish-brown BY2-melanin accumulated in cultured tobacco BY-2 cells
Authors: Islam Abul Taher Mohammed Rafiqul , Shinzato Keita , Miyaoka Hiroki , Komaguchi Kenji , Koike Kanae , Arakawa Kenji , Kitamura Kenji , Tanaka Nobukazu 
Published: January 2023

ABSTRACTThe tobacco BY-2 cell line is one of the most utilized plant cell lines. After long-term culture, the cells turn brown to black, but the causal pigment is unknown. We successfully isolated a blackish-brown pigment from BY-2 cells cultured for 3 weeks. Morphological and spectroscopic analyses indicated that the pigment had similar features to a melanin-like substance reported previously. Furthermore, physicochemical analyses revealed that this pigment possessed most of the properties of melanin-like pigments. In addition, the high nitrogen content suggested that it differed from common plant melanins classified as allomelanins, suggesting a novel eumelanin-like pigment: “BY2-melanin”. This is the first example showing that eumelanin-like pigments are produced in the cultures of plant cells for which the accumulation of melanin has not been reported. This tobacco BY-2 cell culture technique may represent a customizable and sustainable alternative to conventional melanin production platforms, with significant potential for industrial and pharmacological applications.
Evaluation of Social Work Student Placements in General Practice
Authors: Zuchowski Ines , McLennan Simoane , Sen Gupta Tarun 
Published: January 2023

Abstract
Social work and social work student placements in general practice [GP] can contribute to wholistic healthcare. The overall aims of this research were to develop, implement and evaluate a field education placement curriculum for social work student placements in GP clinics. Between December 2021 and June 2022, six students completed their social work placements in four GP practices in North Queensland. Data collection included student records and an online survey that invited students, field educators, task supervisors, mentors, allied health professionals and GPs to provide feedback about the usefulness of the developed materials, the benefits and challenges of the placements, the services provided by the students, patient outcomes and feedback, social work learning, service delivery overall and the value of, and satisfaction with, the social work GP placements. Social work student placements in GP practices offer a valuable broadening of field education learning opportunities for social work and can benefit GP settings. Such placements need to be particularly carefully scaffolded and supported through a comprehensive curriculum, supervision, and a welcoming GP setting. Students interested in embarking in such a learning journey need to be highly confident and competent in social work practice.
Oesophagectomy following noncurative endoscopic resection for oesophageal carcinoma: does interval matter?
Authors: Huang Binhao , Deng Yangqing , Liu Zhichao , Zhu Xiuzhi , Su Yuceng , Gu Dantong , Li Zhigang , Fang Wentao , Pennathur Arjun , Luketich James D , Xiang Jiaqing , Chen Hezhong , Wu Qingquan , Xu Wei , Zhang Jie 
Published: January 2023

Abstract

OBJECTIVES
Oesophagectomy was always recommended after noncurative endoscopic resection (ER). And the optimal time interval from ER to oesophagectomy remains unclear. This study was to explore the effect of interval on pathologic stage and prognosis.

METHODS
We included 155 patients who underwent ER for cT1N0M0 oesophageal cancer and then received subsequent oesophagectomy from 2009 to 2019. Overall survival and disease-free survival (DFS) were analysed to find an optimal cut-off of interval from ER to oesophagectomy. In addition, pathologic stage after ER was compared to that of oesophagectomy. Logistic regression model was built to identify risk factors for pathological upstage.

RESULTS
The greatest difference of DFS was found in the groups who underwent oesophagectomy before and after 30 days (P = 0.016). Among total 155 patients, 106 (68.39%) received oesophagectomy within 30 days, while 49 (31.61%) had interval over 30 days. Comparing the pathologic stage between ER and oesophagectomy, 26 patients had upstage and thus had worse DFS (hazard ratio = 3.780, P = 0.042). T1b invasion, lymphovascular invasion and interval &gt;30-day group had a higher upstage rate (P = 0.014, P &lt; 0.001 and P &lt; 0.001, respectively). And they were independent risk factors for pathologic upstage (odds ratio = 3.782, 4.522 and 2.844, respectively).

CONCLUSIONS
It was the first study exploring the relationship between time interval and prognosis in oesophageal cancer. The longer interval between noncurative ER and additional oesophagectomy was associated with a worse DFS, so oesophagectomy was recommended performed within 1 month after ER. Older age, T1b stage, lymphovascular invasion and interval &gt;30 days were significantly associated with pathologic upstage, which is related to the worse outcome too.
Amiodarone-induced phlebitis: incidence and adherence to a clinical practice guideline
Authors: Brørs Gunhild , Gjeilo Kari Hanne , Lund Tonje , Skevik Karin , Aa Elizabeth , Høvik Lise Husby , Skarsvaag Torhild , Mjølstad Ole Christian 
Published: January 2023

Abstract

Aims
Intravenous amiodarone is an irritant of peripheral blood vessels with phlebitis as an adverse effect. The aims were to determine the incidence of intravenous amiodarone-induced phlebitis, to describe adherence to a clinical practice guideline, and to determine how characteristics were distributed between those with and without phlebitis.

Methods and results
A prospective observational study was conducted. Adult patients treated with amiodarone through a peripheral intravenous catheter (PIVC) or a central venous catheter were included. PIVC characteristics were measured using the PIVC mini questionnaire. Patients with ≥two signs of phlebitis were categorized as having phlebitis. Adherence to the clinical practice guideline was registered on a standard abstract sheet. Data were collected from the amiodarone start-up to 2 days after the amiodarone was discontinued. In total, 124 patients with amiodarone infusions were observed, of which 69% were administered via a PIVC. The phlebitis rate was 44%. Fifty-three per cent developed amiodarone-induced phlebitis during the infusion phase, while 47% presented phlebitis during the post-infusion phase. The three most observed signs or symptoms of phlebitis were redness (87%), pain (81%), and swelling (71%). The most commonly used PIVC site was the elbow, and 35% of the PIVCs were large (18 gauge), which was the last preferred site and size according to the clinical practice guideline.

Conclusion
A large proportion of the patients developed amiodarone-induced phlebitis. The adherence to the clinical practice guideline was not optimal according to the PIVC recommendations. Prevention of amiodarone-induced phlebitis should have high priority to reduce patient harm.
Impact of a public open-access community-based physical activity and fall prevention program on physical performance in older adults
Authors: Sanchez Manuel , Vidal Jean-Sébastien , Bichon Astrid , Mairesse Camille , Flouquet Christiane , Hanon Olivier , Raynaud-Simon Agathe 
Published: January 2023

Abstract

Background
In older adults, physical activity (PA) is important in maintaining physical performance. Data on the effectiveness of public open-access community-based programs on physical performance and fall prevention are scarce.

Methods
Prospective observational controlled study in community centers providing an open-access public prevention program. Retirees aged ≥60 years who chose to participate in weekly PA workshops for 3 months were compared to those who chose the cognitive stimulation (CS) workshops. Collected data: handgrip strength, five times sit-to-stand, single-leg stance, Timed Up and Go tests, gait speed, short physical performance battery (SPPB) and frailty status at baseline (M0) and at 3 months (M3). The proportion of participants reporting a history of falls was assessed at baseline and using follow-up telephone interviews (F-Up).

Results
Two hundred eighty-eight participants (age 73.8 years, 87% women) were included. The sit-to-stand test, single-leg stance and SPPB scores improved significantly between M0 and M3 in both groups. A greater SPPB increase was observed in the PA than in the CS group (+0.39 vs. +0.32 points, P = 0.02) after adjustment for age, sex, number of sessions attended, fall history and SPPB at baseline. During F-Up (median 22 months), the proportion of participants reporting at least one fall decreased from 55% to 31% (P = 0.01) in the PA group and from 27% to 19% (P = 0.12) in the CS group.

Conclusion
In a public open-access community-based program participants improved physical performance and reduced fall incidence when participating in the PA or the CS workshops. Older adults may benefit most from multifaceted prevention programs.