bluuebunny/crossref_metadata_2025_split huggingface dataset:
CuII Pyrazolyl‐Benzimidazole Dinuclear Complexes with Remarkable Antioxidant Activity
Authors: Chkirate Karim , Ati Gamal Al , Karrouchi Khalid , Fettach Saad , Chakchak Hind , Mague Joel T. , Radi Smaail , Adarsh N. N. , Abbes Faouzi My El , Essassi El Mokhtar , Garcia Yann 
Published: August 2023

AbstractThree dinuclear coordination complexes generated from 1‐n‐butyl‐2‐((5‐methyl‐1H‐pyrazole‐3‐yl)methyl)‐1H‐benzimidazole (L), have been synthesized and characterized spectroscopically and structurally by single crystal X‐ray diffraction analysis. Reaction with iron(II) chloride and then copper(II) nitrate led to a co‐crystal containing 78 % of [Cu(NO3)(μ‐Cl)(L’)]2 (C1) and 22 % of [Cu(NO3)(μ‐NO3)(L’)]2 (C2), where L was oxidized to a new ligand L’. A mechanism is provided. Reaction with copper chloride led to the dinuclear complex [Cu(Cl)(μ‐Cl)(L)]2 (C3). The presence of N−H⋅⋅⋅O and C−H⋅⋅⋅O intermolecular interactions in the crystal structure of C1 and C2, and C−H⋅⋅⋅N and C−H⋅⋅⋅Cl hydrogen bonding in the crystal structure of C3 led to supramolecular structures that were confirmed by Hirshfeld surface analysis. The ligands and their complexes were tested for free radical scavenging activity and ferric reducing antioxidant power. The complex C1/C2 shows remarkable antioxidant activities as compared to the ligand L and reference compounds.
Ru(II)‐Cyanine Complexes as Promising Photodynamic Photosensitizers for the Treatment of Hypoxic Tumours with Highly Penetrating 770 nm Near‐Infrared Light
Authors: Gandioso Albert , Izquierdo‐García Eduardo , Mesdom Pierre , Arnoux Philippe , Demeubayeva Nurikamal , Burckel Pierre , Saubaméa Bruno , Bosch Manel , Frochot Céline , Marchán Vicente , Gasser Gilles 
Published: August 2023

AbstractLight‐activated treatments, such as photodynamic therapy (PDT), provide temporal and spatial control over a specific cytotoxic response by exploiting toxicity differences between irradiated and dark conditions. In this work, a novel strategy for developing near infrared (NIR)‐activatable Ru(II) polypyridyl‐based photosensitizers (PSs) was successfully developed through the incorporation of symmetric heptamethine cyanine dyes in the metal complex via a phenanthrimidazole ligand. Owing to their strong absorption in the NIR region, the PSs could be efficiently photoactivated with highly penetrating NIR light (770 nm), leading to high photocytotoxicities towards several cancer cell lines under both normoxic and hypoxic conditions. Notably, our lead PS (Ru‐Cyn‐1), which accumulated in the mitochondria, exhibited a good photocytotoxic activity under challenging low‐oxygen concentration (2 % O2) upon NIR light irradiation conditions (770 nm), owing to a combination of type I and II PDT mechanisms. The fact that the PS Protoporphyrin IX (PpIX), the metabolite of the clinically approved 5‐ALA PS, was found inactive under the same challenging conditions positions Ru‐Cyn‐1 complex as a promising PDT agent for the treatment of deep‐seated hypoxic tumours.
Chemical Tailoring of β‐Cyclodextrin‐Graphene Oxide for Enhanced Per‐ and Polyfluoroalkyl Substances (PFAS) Adsorption from Drinking Water
Authors: Tunioli Francesca , Marforio Tainah D. , Favaretto Laura , Mantovani Sebastiano , Pintus Angela , Bianchi Antonio , Kovtun Alessandro , Agnes Marco , Palermo Vincenzo , Calvaresi Matteo , Navacchia Maria Luisa , Melucci Manuela 
Published: August 2023

AbstractWe report on the synthesis of β‐cyclodextrin (βCD) modified graphene oxide (GO) nanosheets, having different sized alkyl linkers (GO‐Cn‐βCD) and their exploitation as sorbent of per‐ and polyfluoroalkyl substances (PFAS) from drinking water. βCD were functionalized with a pending amino group, and the resulting precursors grafted to GO nanosheets by epoxide ring opening reaction. Loading of βCD units in the range 12 %–36 % was estimated by combined XPS and elemental analysis. Adsorption tests on perfluorobutanoic acid (PFBA), a particularly persistent PFAS selected as case study, revealed a strong influence of the alkyl linker length on the adsorption efficiency, with the hexyl linker derivative GO‐C6‐βCD outperforming both pristine GO and granular activated carbon (GAC), the standard sorbent benchmark. Molecular dynamic simulations ascribed this evidence to the favorable orientation of the βCD unit on the surface of GO which enables a strong contaminant molecules retention.
Chemoimmunotherapy in patients with extensive‐stage small cell lung cancer and a poor performance status
Authors: Agarwal Muskan , Liu Alex , Almquist Daniel , Langlais Blake T. , Leventakos Konstantinos , Yu Nathan Y. , Manochakian Rami , Ernani Vinicius 
Published: August 2023

AbstractBackgroundImmune checkpoint inhibitor combined with platinum‐etoposide is the standard first‐line therapy for patients with extensive‐stage small cell lung cancer (ES‐SCLC). The phase 3 clinical trials that led to the approval of chemoimmunotherapy in ES‐SCLC excluded patients who had an Eastern Cooperative Group (ECOG) performance status (PS) of 2–3. Therefore, data on the efficacy of chemoimmunotherapy in patients with an ECOG PS of 2–3 are limited.MethodsA retrospective analysis was performed on patients diagnosed with ES‐SCLC who received chemoimmunotherapy (atezolizumab or durvalumab) within the Mayo Clinic Health System between January 2016 and January 2021. The objective of this study was to compare the overall survival (OS), progression‐free survival (PFS), and best clinical response to therapy in patients with an ECOG PS of 0–1 vs. patients with an ECOG PS of 2–3 who received chemoimmunotherapy for newly diagnosed ES‐SCLC.ResultsIn total, 82 patients were included in the study. The mean ± standard deviation age was 68.1 ± 8.3 years. Of these, 56 patients were identified with an ECOG PS of 0–1, and 26 patients were identified with an ECOG PS of 2–3. The median PFS was similar regardless of ECOG PS (5.8 months [95% CI, 4.3–6.0 months] in the ECOG PS 0–1 group vs. 4.1 months [95% CI, 3.8–6.9 months] in the ECOG PS 2–3; p = .2994). The median OS was also similar regardless of ECOG PS (10.6 months [95% CI, 8.4–13.4 months] in the ECOG PS 0–1 group vs. 9.3 months [95% CI, 4.9–12.8 months]; p = .2718) in the ECOG PS 2‐3 group.ConclusionsThe study results demonstrated no significant difference in PFS or OS among the ECOG PS 2–3 and ECOG PS 0–1 groups. Therefore, chemoimmunotherapy should be considered for patients who have ES‐SCLC with an ECOG PS of 2–3.
Convergence in patient and therapist alliance ratings early in treatment with Personality Assessment Inventory clinical scales and subscales
Authors: Cersosimo Bianca H. , Hilsenroth Mark J. , Bornstein Robert F. , Gold Jerold R. , Blais Mark A. 
Published: August 2023

AbstractWe examined discrepancies in 81 patient‐therapist dyads' alliance ratings early in treatment (3rd or 4th session) in relation to Personality Assessment Inventory clinical scales, subscales and global psychopathology. Results indicated that PAI global psychopathology (mean clinical elevation) and the scales of Aggression [AGG], Somatization [SOM], and Anxiety‐Related Disorders [ARD] were significantly, negatively associated with an absolute difference of patient and therapist alliance ratings at Session 3. Higher initial scores on these clinical scales at treatment onset are associated with less difference (i.e., more convergence) in patient/ therapist ratings of alliance at Session 3. Correlations between PAI clinical subscales and absolute differences of patient and therapist alliance ratings at Session 3 also demonstrated statistically significant inverse relationships for several PAI subscales of Aggression‐ Attitude [AGG‐A], Aggression‐Physical [AGG‐P], Somatic‐ Health Concerns [SOM‐H], Anxiety‐Related Disorders‐Traumatic Stress [ARD‐T], Anxiety‐Related Disorders‐ Obsessive Compulsive [ARD‐O], Borderline Features‐Affective Instability [BOR‐A], Borderline‐ Self‐Harm [BOR‐S], Anxiety‐Physiological [ANX‐P], Depression‐Physiological [DEP‐P] and Antisocial‐Stimulus Seeking [ANT‐S]. Again, higher scores on these subscales at treatment onset are associated with less difference (i.e., more convergence) in patient/therapist ratings. We also examined group differences between patients rating alliance higher (Group 1) and therapists rating alliance higher (Group 2) and found that Group 1 had significantly lower scores on Mania‐Activity Level [MAN‐A]. Clinical implications of results are discussed.
A Zwitterionic Tetrastanna(II) Cyclic Crown
Authors: Sahoo Padmini , Chibde Purva , Das Satyabrata , Banerjee Subhrashis , Mali Bhupendra P. , Vanka Kumar , Gonnade Rajesh G. , Yildiz Cem. B. , Majumdar Moumita 
Published: August 2023

AbstractA 12‐membered zwitterionic tetrastanna(II) cycle 1 having a crown ether‐like topology has been isolated from the deprotonation of 1,1′‐methylenediimidazole (B) with two equivalents of Sn[N(SiMe3)2]2 (A). The solid‐state structure and NMR analysis confirms the tetrastanna(II) cycle 1 to be comprised of two stannate(II) and two stannyliumylidene ion pairs in alternating positions of the heterocycle. Computational analysis shows greater nucleophilicity at the proximally located stannate(II) centers. Nonetheless, the tetrastanna(II) cycle 1 remains poorly reactive due to engagement of SnII lone pair electrons in intramolecular donor‐acceptor interactions. Simple deprotonation reaction between Sn[N(SiMe3)2]2 (A) and N‐(diisopropylphenyl)imidazole (C) in equimolar ratio has led to a stannylene 2, involving the formation of a Sn−C covalent bond with the anionic imidazol‐2‐yl carbon center along with the release of NH(SiMe3)2. Compound 2 exists as a dimer, where the unsubstituted ring nitrogen atom coordinated intermolecularly to the other stannylene center.
Sexual violence and traumatic identity change: Evidence of collective post‐traumatic growth
Authors: Muldoon Orla T. , Nightingale Alastair , Lowe Robert , Griffin Siobhan M. , McMahon Grace , Bradshaw Daragh , Borinca Islam 
Published: August 2023

AbstractRecent research indicates that social identities play a crucial role in the connection between adversity, post‐traumatic stress, and overall psychological well‐being. Understanding of how trauma influences collective dimensions of the self, positively or negatively, is limited. This study focuses on analysing publicly accessible narratives of four women who chose to waive their anonymity after the conviction of the men who had attacked and sexually assaulted them in Ireland. Thematic analysis highlighted two themes that signal (i) collective dimensions to this personal trauma, (ii) attempts to reconstruct social identities in the aftermath of trauma. Women presented their experiences as having the potential to amplify positive connections with others despite the wider embedded sociocultural understanding of sexual assault. These changes were associated with redefinition of social identities. Discussion highlights the potential for personal and intimate trauma to result in positive social identity change; a phenomenon that we label collective post‐traumatic growth.
The role of Transcription Factor IIH complex in nucleotide excision repair
Authors: Hoag Allyson , Duan Mingrui , Mao Peng 
Published: August 2023

AbstractDNA damage occurs throughout life from a variety of sources, and it is imperative to repair damage in a timely manner to maintain genome stability. Thus, DNA repair mechanisms are a fundamental part of life. Nucleotide excision repair (NER) plays an important role in the removal of bulky DNA adducts, such as cyclobutane pyrimidine dimers from ultraviolet light or DNA crosslinking damage from platinum‐based chemotherapeutics, such as cisplatin. A main component for the NER pathway is transcription factor IIH (TFIIH), a multifunctional, 10‐subunit protein complex with crucial roles in both transcription and NER. In transcription, TFIIH is a component of the pre‐initiation complex and is important for promoter opening and the phosphorylation of RNA Polymerase II (RNA Pol II). During repair, TFIIH is important for DNA unwinding, recruitment of downstream repair factors, and verification of the bulky lesion. Several different disease states can arise from mutations within subunits of the TFIIH complex. Most strikingly are xeroderma pigmentosum (XP), XP combined with Cockayne syndrome (CS), and trichothiodystrophy (TTD). Here, we summarize the recruitment and functions of TFIIH in the two NER subpathways, global genomic (GG‐NER) and transcription‐coupled NER (TC‐NER). We will also discuss how TFIIH's roles in the two subpathways lead to different genetic disorders.
Food safety knowledge among 7th‐grade middle school students: A report of a Brazilian municipal school using workshop‐based educational strategies
Authors: Brandão Maria Aparecida da Ressurreicão , Bello Maria Elvira do Rego Barros , de Souza Manuella Farias , Carvalho Maria Rita de Jesus , Maciel Bianca Mendes 
Published: August 2023

AbstractPractical methodologies that include food safety and hygiene education in pedagogical activities are strategies to prevent foodborne diseases (FBDs). Thus, the aim of this study was to investigate the knowledge of 7th‐grade middle school students regarding food microbiology and food safety, and to apply workshop‐based educational strategies that focus on scientific literacy. The students (144) were initially evaluated using a Likert‐scale questionnaire (pre‐intervention, Q0) with ten objective questions on microbiology and food safety. Once the questionnaire was evaluated, interventions were conducted through five science workshops of 50 min, over a period of 5 months. The workshops included educational games, laboratory practices, videos, and lectures that addressed microorganisms that are known to cause the most common FBDs in Brazil. After each workshop, students were asked to express their opinions and understanding of the content through semi‐structured interviews. Six months after the end of the practical interventions, the students completed a second identical Likert‐scale questionnaire (post‐intervention, Q1), and the answers to both questionnaires (Q0 and Q1) were analyzed by calculating the middle rank. The middle rank of Q1 (mean = 0.65 ± 0.13) was 21% greater than the middle rank of Q0 (mean = 0.44 ± 0.16), and statistical significance was observed (p = .0135). This demonstrates that new information acquired during the workshops positively influenced learning. We believe that when practical approaches to food safety are included in school education as a priority, the prevalence of FBD will decrease.
Report of a vagal paraganglioma at the cervicothoracic junction
Authors: Yun Jun , Kapustin Danielle , Omorogbe Aisosa , Rubin Samuel J. , Nicastri Daniel G. , De Leacy Reade A. , Khorsandi Azita , Urken Mark L. 
Published: August 2023

AbstractBackgroundVagus nerve paragangliomas are rare tumors, comprising 0.03% of head and neck neoplasms. These tumors are usually located cephalad to the hyoid bone, and there is only one previously reported case that arose from the lower third of the neck.MethodsWe describe the second reported case of a lower neck vagus nerve paraganglioma that was managed with a limited sternotomy for access and surgical removal.ResultsA 66‐year‐old male presented with a long‐standing lesion of the cervicothoracic junction. CT, MRI, and Ga‐68 DOTATATE PET/CT showed an avidly enhancing 5.2 × 4.2 × 11.5 cm mass extending from C6 to approximately T4 level. FNA confirmed the diagnosis. The patient underwent catheter angiography and embolization via direct puncture technique followed by excision of the mass via a combined transcervical and limited sternotomy approach.ConclusionWe describe an unusual case of vagal paraganglioma at the cervicothoracic junction with retrosternal extension requiring a sternotomy for surgical excision.
‘I actually thought that I was going to die’: Lessons on the rip current hazard from survivor experiences
Authors: Cornell Samuel , Brander Robert W. , Roberts Amelia , Koon William , Peden Amy E. , Lawes Jasmin C. 
Published: August 2023

AbstractBackgroundRip currents are strong, narrow, fast‐flowing currents of water that occur on many beaches and in Australia contributing to 26 drowning deaths and several thousand lifeguard/lifesaver rescues each year. Educating the public about the rip current hazard is a primary focus of beach safety practitioners, but there has been a lack of qualitative research exploring the firsthand experiences of being caught in a rip current to assist in this regard. The aim of this study was to analyse interviews of rip current survivors to understand more about how people react when unintentionally caught in a rip current in order to help guide future public education to mitigate rip current drowning.MethodsSemi‐structured interviews were conducted with 56 individuals (primarily Australian‐born) about their experience of being caught in a rip current. Interviewees were recruited via an online survey and varied in age and self‐reported swimming ability.ResultsThematic analysis revealed three key temporal elements to the rip current experience: Before the Rip in which lack of awareness and knowledge, complacency, over‐confidence, and attitude were prevalent themes; During the Rip which identified panic and temporary inhibition of decision‐making, physical response, prior experience, and relationships with other beach users as themes; and After the Rip where post‐rip effects and rip safety messaging and education were key themes. The importance of experiential immersion was a prevalent thread throughout all phases of the thematic analysis.DiscussionOur research shows that being caught in a rip current can be an intense and traumatic experience and that lessons learned from survivors have significant implications for improving existing and future rip current education efforts. In this regard, we provide several recommendations based on evidence‐based insights gained from our interviews including the development of immersive rip current experience using virtual reality.So WhatDespite the prevalence of rip currents causing drowning deaths and rescues, there has been a lack of qualitative research on firsthand experiences to aid in public education. These interviews emphasise the intense and traumatic nature of being caught in a rip current, underscoring the need for improved rip current education to aid in prevention of this, often harrowing, experience.
Maternal childhood adversity and adolescent marijuana use at age 17 years: The role of parental mental health and parenting behaviors
Authors: Okine Lucinda , Cederbaum Julie A. , Duan Lei , Lee Jungeun O. 
Published: August 2023

AbstractIntroductionChildren's risk for marijuana use may be linked to their parents' history of childhood adversity, yet little is known about the mechanisms underlying this link. This study examined whether maternal parenting behavior and mental health serve as mechanisms linking maternal childhood adversity to their children's marijuana use at age 17 years, by gender.MethodsData were from the Young Women and Child Development Study (59% male), a longitudinal panel study, which began in 1988 and followed mother–child dyads for 17 years (n = 240). Participants were recruited from health and social services agencies located in a metropolitan region of Washington State. Hypotheses were tested using Structural Equation Modeling in Mplus. Multiple‐group analysis was conducted to evaluate potential gender differences.ResultsResults showed that maternal childhood adversity was associated with their mental health outcomes (β = .32, p < .001), which in turn was predictive of mothers' harsh parenting (β = .27, p < .01). Maternal harsh parenting behavior was then associated with their children's marijuana use at age 17 years (β = .34, p < .001). Multiple group analyses revealed that the path from harsh parenting to adolescent marijuana use differed across genders being only significant for boys (β = .42, p < .001).ConclusionsThe intergenerational impact of childhood adversity highlights the need for interventions that target both parents and children. This would support teen mothers with a history of childhood adversity to acquire skills and knowledge to help mitigate its impact on their parenting behaviors and offset risks for their children.
For safe and fast surgery: Utilization of the SAND balloon catheter for acute cholecystitis
Authors: Yasukawa Koya , Shimizu Akira , Kubota Koji , Notake Tsuyoshi , Hayashi Hikaru , Tomida Hidenori , Kuroiwa Yudai , Nakamura Kenya , Hongo Yuta , Soejima Yuji 
Published: August 2023

AbstractBackgroundThe utility of the SAND balloon catheter in laparoscopic cholecystectomy for acute cholecystitis (AC) remains unclear.MethodsA retrospective cohort study of patients who underwent emergency cholecystectomy at Shinshu University was performed to evaluate the efficacy of the SAND balloon catheter in cases of AC (SAND balloon utilization: Group S, n = 44; non‐utilization: Group non‐S, n = 47).ResultsThe duration of surgery was significantly shorter in Group S than in Group non‐S (p = .031). Despite comparable incidences of blood transfusions in the two groups, intraoperative blood loss was significantly less in Group S than in Group non‐S (p = .013). The incidence of postoperative intraperitoneal infection tended to be higher in Group non‐S (p = .076). Within Group non‐S, bile spillage during operation was found in 16 (34.0%) patients. The multivariate analysis revealed that gangrenous AC was the strongest independent risk factor for bile spillage during operation (odds ratio [OR]: 19.1; 95% confidence interval [CI]: 2.84–78.4; p = .002), followed by surgeons with ≤10 years of experience (OR: 11.3; 95% CI: 1.81–70.6; p < .010).ConclusionsImplementation of the SAND balloon catheter in patients with AC is a safe and efficacious surgical option. This catheter is recommended in cases of gangrenous cholecystitis and for surgeons with limited experience.
The green novel approach in hydrolysis of pistachio shell into xylose by microwave‐assisted high‐pressure CO2/H2O
Authors: Hazal Filiz , Özbek Hatice Neval , Göğüş Fahrettin , Yanık Derya Koçak 
Published: August 2023

AbstractBACKGROUNDPistachio shell is a valuable lignocellulosic biomass because almost 90% of its hemicellulose fraction is xylan, which can be converted into high value‐added compounds such as xylooligosaccarides, xylose, xylitol and furfural. The present study represents a green and novel approach to produce xylose from lignocellulosic biomass. Microwave‐assisted high‐pressure CO2/H2O hydrolysis (MW‐HPCO2) comprising a combination never previously used was performed to produce xylose from pistachio shell.RESULTSResponse surface methodology with a Box–Behnken design was implemented to optimize microwave‐assisted high‐pressure CO2/H2O hydrolysis (MW‐HPCO2). The effect of temperature, time and liquid‐to‐solid ratio was studied in the ranges of 180–210 °C, 10–30 min and 5–30 mL g−1, respectively. A maximum xylose yield of 61.39% and minimum degradation compounds (5‐hydroxymethyl furfural and furfural) of 11.07% were attained under reaction conditions of 190 °C, 30 min and 18 mL g−1.CONCLUSIONThe results showed that hydrolysis temperature, time and liquid‐to‐solid ratio had a strong influence on the xylose yield, as well as on the formation of degradation compounds. MW‐HPCO2 significantly increased accessibility to cellulose‐derived products in the subsequent enzymatic hydrolysis. The results of the present study reveal that MW‐HPCO2 can be a promising green technique for the hydrolysis of lignocellulosic biomass. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.