bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bladder Preservation With Transurethral Tumor Resection and Intravesical BCG Instillation in Superficial Muscle-Invasive Bladder Cancer: A 10-Year Follow-up
Authors: Kim Dong Gyun , Heo Ji Eun , Cho Kang Su , Lee Jongsoo , Jang Won Sik , Cho Nam Hoon , Choi Young Deuk 
Published: March 2023

Purpose: The aim of this study was to evaluate the 10-year oncological outcomes of bladder preservation with transurethral resection of bladder tumor (TURBT) and intravesical bacillus Calmette-Guérin (BCG) instillation in selected patients with superficial muscle-invasive bladder cancer (MIBC).Materials and Methods: Patients diagnosed with superficial MIBC (stage T2a) by TURBT between 2001 and 2009 were included. Cystectomy-free survival, recurrence-free survival (RFS), progression-free survival (PFS), and cancer-specific survival (CSS) were estimated using the Kaplan-Meier method. Cox regression analysis was used to identify predictors of each type of survival.Results: Of 145 patients, 135 underwent bladder preservation and 10 underwent immediate radical cystectomy (RC). Among the latter, 9 patients showed downstaging. During a median follow-up of 132 months (interquartile range, 96–161 months), 13 patients underwent RC, with a 10-year cystectomy-free survival rate of 83.9%. Seventy patients (48.3%) had recurrence, and the 10-year RFS rate was 48.9%. Progression occurred in 12 patients (8.3%), with a 10-year PFS rate of 90.1%. Death occurred only in patients who exhibited progression; 5 patients (3.4%) died of bladder cancer, and the 10-year CSS rate was 96.5%. Tumors greater than 3 cm were associated with RC, and a high tumor grade predicted recurrence. RC was related to progression and cancer-specific mortality.Conclusions: Although high-grade tumors require careful follow-up, bladder preservation with TURBT and intravesical BCG instillation can enable the successful management of selected patients with stage T2a MIBC less than 3 cm, without carcinoma in situ or tumor-associated hydronephrosis, in a nonmetastatic setting.
Effect of Biopotting Quality on Growth and Morphological Quality of Jackfruit Artocarpus heterophyllus Lamk. Seedlings
Authors: Santosa Slamet , Munif Said Hassan  , Abdul Hayat Kasim  , Rizki A.P. Santosa  
Published: March 2023

Biopotting was a pot of growing medium for plant seedlings that was environmentally friendly. This study analyzed the effect of biopotting quality made from clay, fruit waste compost of rambutan, jackfruit, durian, market compost and tapioca flour on the growth and morphological quality of jackfruit seedlings. The results of the chemical analysis of biopotting samples containing organic C ranged from 42- 44%, total N ranged from 0.21-0.35%, total P ranged from 28.14-38.25 mgkg-1, potassium (K) ranged from 0.90-1.13me/100g and pH ranged from 4.08-6.68. Physical analysis of biopotting obtained water content ranged from 2.04-3.09%, density ranged from 0.42-0.50gcm-3, water absorption ranged from 200-242% and the level of damage to all biopotting was ≤ 2% so it was included in the undamaged category. Measurement of growth and morphological quality of jackfruit seedlings aged 60 days obtained an average height ranged from 17.85-27.6cm, an average of stem diameter ranged from 0.43-0.47cm, number of leaves ranged from 3-4 strands, root length ranged from 12.5-16.8cm and morphological quality index ranged from 0.092- 0.099. This study concluded that the best quality on M4 biopotting had a significant effect on the growth and morphological quality of the jackfruit Artocarpus heterophyllus Lamk. seedlings
Pyrolysis of Saw Waste Biomass Mahogany Wood and Polypropylene Plastic
Authors: Safitri Diya Zalfa Aisyah , Wijayanto Danar Susilo , Saputra Taufik Wisnu 
Published: March 2023

Fuel requirement increased along with the increased of population also industrial progress, meanwhile the alternative fuel always decreasing. People also faced by the problem of increasing amount of waste, either its organic or anorganic. In this case mahogany waste and polypropylene plastic waste which still rarely used by people can be a solution to make an alternative fuel processed by pyrolysis process. This study is using experiment method with analysis descriptive quantitative technique. This study conducted with pyrolysis process to mixed biomass sawdust mahogany and polypropylene plastic waste with the 100%-0%,75%:25%, 50%:50%, 25%:25%, and 0%:100% ratio, next are do pyrolysis oil test which was quantity test. there is an influence of variety mixed biomass sawdust mahogany and polypropylene plastic waste ratio to quantity of pyrolysis oil. The most quantity is produced by mixed variety 100% of polypropylene plastic as much as 1026,67 ml with 391°C temperature on T1, 345°C on T2, 367,75°C on T3.
Analysis of Magnetic Material Abundance in Black Sand
Authors: Rachmawati Dewi Oktofa , Nurfa Risha  , Iwan Suswandi  
Published: March 2023

The analysis of the magnetic material abundance on the black sand of Nyanyi beach revealed magnetic material content, grain size, density, magnetic mineral content, and magnetic susceptibility value.The results of this study can be used for black sand development inTabanan district. The black sand magnetic material was determined by the extraction method. Mineral content was tested by using XRF equipment, and the magnetic properties of black sand were determined by using a Bartingtons MS2 Magnetic Susceptibility Meter and a Vibrating Sample Magnetometer. The data were analyzed descriptively quantitatively. The results show thatNyanyi beach sand physically has a characteristic dark gray color, tends to be black, and shiny with a weight fraction of magnetic material reaching 95.52%.The density of the magnetic material is 2072.6 with varying grain sizes of 53 600 .The average value of magnetic susceptibility is 27.212x 10-with Fe2O3magnetic mineral content of 86.68% and the element of Fe is 89.41%.The values of saturation magnetization, remanance magnetization, and coervicity reach37.74; 4.64; 103.93 Oe.
PENGARUH SUPLEMENTASI TEPUNG MAGGOT (BLACK SOLDIER FLY) TERHADAP PERFORMA AYAM JOPER FASE STARTER
Authors: Julian Hendrik , Sutrisna Rudy , Riyanti Riyanti , Nova Khaira 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui pengaruh suplementasi tepung Maggot (Black Soldier Fly) dan level pemberian terbaik terhadap performa ayam joper fase starter. Penelitian ini dilaksanakan pada Januari--Maret 2022 dan berlokasi di Jl. Padat Karya No.6, Labuhan Dalam, Kec. Tj. Senang, Kota Bandar Lampung. Rancangan percobaan menggunakanancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 5 ulangan, sehingga berjumlah 20 unit percobaan. Perlakuan yang diberikan yaitu ransum BR-1 (P0), ransum BR-1 dengan suplementasi 5% tepung Maggot (P1), ransum BR-1 dengan suplementasi 10% tepung Maggot (P2), dan ransum BR-1 dengan suplementasi 15% tepung Maggot (P3). Peubah yang diukur adalah konsumsi ransum, pertambahan bobot tubuh, konversi ransum dan income over feed cost. Data yang diperoleh dianalisis menggunakan Analisis of Varians (ANOVA) dengan taraf nyata 5% dan atau 1% kemudian dilanjutkan dengan uji lanjut Duncan. Hasil penelitian menunjukan bahwa suplementasi tepung Maggot pada BR-1 tidak berpengaruh nyata (P>0,05) terhadap konsumsi ransum dan pertambahan bobot tubuh, tetapi berpengaruh nyata (P<0,05) terhadap konversi ransum dan berpengaruh sangat nyata (P<0,01) terhadap income over feed cost. Konsumsi ransum, pertambahan bobot tubuh, konversi ransum dan income over feed cost terbaik terdapat pada perlakuan kontrol (P0).
GAMBARAN DARAH (Eritrosit, Hemoglobin, dan Hematokrit) AYAM KAMPUNG JANTAN (Gallus gallus domesticus) SETELAH PEMBERIAN IMUNOMODULATOR EKSTRAK SAMBILOTO (Andrographis paniculata)
Authors: Rahmawati Reni , Siswanto Siswanto , Nova Khaira , Santosa Purnama Edy 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui gambaran darah (eritrosit, hemoglobin, dan hematokrit) pada ayam kampung jantan yang diberi ekstrak Sambiloto (Andrographis paniculata). Penelitian dilaksanakan pada Januari--Maret 2022 di unit kandang Laboratorium Lapang Terpadu, Fakultas Pertanian, Universitas Lampung. Pemeriksaan sampel darah dilakukan di Laboratorium Patologi Klinik, Fakultas Kedokteran Hewan, Universitas Gadjah Mada. Penelitian menggunakan 4 perlakuan dan 3 ulangan. Perlakuan yang diberikan melalui air minum dengan P0: (kontrol), P1: 3 mg/kg BB/hari ekstrak Sambiloto (Andrographis paniculata), P2: 6 mg/kg BB/hari ekstrak Sambiloto (Andrographis paniculata), P3: 12 mg/kg BB/hari ekstrak Sambiloto (Andrographis paniculata). Data yang diperoleh dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa ayam kampung jantan yang diberikan ekstrak Sambiloto dapat mempertahankan jumlah eritrosit, hemoglobin, dan hematokrit pada kisaran normal.
PENGARUH PENGOLAHAN KIMIA DAN BIOLOGIS PADA KELOBOT JAGUNG TERHADAP KANDUNGAN ADF DAN NDF
Authors: Rahman First Riyatna , Sutrisna Rudy , Fathul Farida , Liman Liman 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pengolahan kimia dan biologis serta pengolahan terbaik pada kelobot jagung terhadap kandungan ADF dan NDF. Penelitian ini dilaksanakan pada Januari sampai Maret 2022 bertempat di lahan perkebunan milik petani, kecamatan Tanjung Bintang, Lampung Selatan, dan Laboratorium nutrisi dan teknologi pakan, Jurusan peternakan, Universtas Lampung, serta Laboratorium nutrisi perah, fakultas peternakan, Institut Pertanian Bogor. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan dan 4 ulangan sehingga terdapat 16 satuan percobaan. Perlakuan yang digunakan yaitu P1 (Kontrol), P2 (amoniasi), P3 (fermentasi), dan P4 (amofer). Data yang diperloleh analisis ragam pada taraf nyata 5% dan 1% yang selanjutnya dianalisis menggunakan uji lanjut Berganda Duncan. Hasil analisis ragam menunjukkan bahwa perlakuan amoniasi, fermentasi, dan amofer berpengaruh nyata (P<0,05) terhadap kadar ADF dan NDF. Disimpulkan bahwa perlakuan terbaik untuk menurunkan kadar ADF dan NDF pada kelobot jagung yaitu menggunakan pengolahan amofer dengan hasil kadar ADF 41,36% dan NDF 82,55%.
TINGKAT INFESTASI DAN JENIS PARASIT SALURAN PENCERNAAN PADA SAPI PERANAKAN SIMENTAL DI KECAMATAN TULANG BAWANG UDIK KABUPATEN TULANG BAWANG BARAT
Authors: Khair Ajmal Kurniawan , Hartono Madi , Wanniatie Veronica , Dakhlan Akhmad 
Published: March 2023

Penelitian yang dilaksanakan pada Oktober 2022 yang bertujuan untuk mengetahui tingkat infestasi dan jenis parasit saluran pencernaan pada Sapi Peranakan Simental di Kecamatan Tulang Bawang Udik, Kabupaten Tulang Bawang Barat. Metode penelitian yang digunakan adalah metode survei. Jumlah sampel yang diperoleh yaitu 113 sampel yang berasal dari 71 peternak. Pemeriksaan sampel feses sapi Peranakan Simental dilakukan di Balai Veteriner, Kota Bandar Lampung menggunakan metode Mc. Master dan uji Sedimentasi. Data disajikan dalam bentuk tabel dan histogram, kemudian dianalisis secara deskriptif. Hasil menunjukkan bahwa jenis parasit saluran pencernaan yang menginfestasi sapi Peranakan Simental di Kecamatan Tulang Bawang Udik Kabupaten Tulang Bawang Barat yaitu Paramphistomum sp., Eimeria, Haemoncus sp., Oesophagustomum sp., Fasciola sp., Toxocara sp., dan Tricuris sp. Tingkat infestasi parasit saluran pencernaan pada Sapi Peranakan Simental di Kecamatan Tulang Bawang Udik sebesar 73,45% dengan prevalensi cacing sebesar 61,06% dan prevalensi Eimeria sebesar 49,56%. Infestasi tunggal parasit saluran pencernaan pada sapi Peranakan Simental sebesar 38,55% (Paramphistomum sp., Eimeria, Haemoncus sp., Oesophagustomum sp., Fasciola sp., Toxocara sp., dan Tricuris sp.), infestasi campuran 2 jenis parasit saluran pencernaan (Paramphistomum sp. dan Eimeria, Haemoncus sp. dan Paramphistomum sp., Oesophagustomum sp dan Eimeria) sebesar 45,78%, infestasi 3 jenis parasit saluran pencernaan (Haemoncus sp., Paramphistomum sp., dan Eimeria, Oesophagustomum sp Paramphistomum sp, dan Eimeria, Haemoncus sp., Fasciola sp, dan Eimeria) sebesar 14.46%, dan infestasi campuran lebih dari 3 jenis parasit saluran pencernaan (Haemonchus sp., Trichuris sp., Paramphistomum sp., dan Eimeria) sebesar 1,20%.
Oclacitinib 10 years later: lessons learned and directions for the future
Authors: Marsella Rosanna , Doerr Katherine , Gonzales Andrea , Rosenkrantz Wayne , Schissler Jennifer , White Amelia 
Published: March 2023

Abstract
Oclacitinib was approved in the United States 10 years ago for the management of atopic dermatitis (AD) and allergic skin disease in dogs. Many studies and case reports have been published in the past 10 years on the efficacy and safety of this medication, both at labeled doses to treat allergic dogs and off label to treat other diseases and given to other species. Concerns and confusion have occurred for both clinicians and owners regarding the long-term safety of this drug. The purpose of this review is to present the current knowledge on the efficacy, speed of action, effects on the immune system, and clinical safety of oclacitinib, based on evidence and published literature. We also aim to summarize the lessons learned in the past 10 years and to propose directions for the future.
A Platform for Collaboration: The Views of Civil Society Organisations on a Local Compact
Authors: Kolmodin Sophie 
Published: March 2023

ABSTRACT
A considerable degree of collaboration between civil society organisations (CSOs) and governmental organisations (GOs) occurs in various collaborative areas, such as collaborative platforms, that aim to increase mutual understanding and reach shared solutions to complex social challenges. However, little is known regarding how CSOs relate to and discuss the starting conditions for participating in collaborative platforms. By highlighting the perspectives of CSOs supporting refugees, this article shows that the starting conditions affect whether CSOs decide to participate. Nevertheless, the starting conditions are also essential for their general understanding of the platform’s aim and purpose, thus affecting more than the initial decision to participate or not. A primary barrier to their participation is the political agenda behind the platform and what role CSOs think they should have in society. Consequently, the inclusive ‘whole society approach’ that collaborative platforms intend to create might be out of reach before starting the collaboration.
Current-zero-crossing Shift for Compensation of Dead-time Distortion in Pulse-width-modulated Voltage Source Inverter
Authors: Chatterjee Dipankar , Chakraborty Chandan , Mukherjee Kaushik , Dalapati Suvarun 
Published: March 2023

Abstract
Accurate current polarity detection is a major issue for successful compensation of dead-time distortion in pulse-width-modulated (PWM) voltage source inverter. The present study is concerned with the concept of shift in current-zero-crossing due to dead-time distortion compensation that results in error in current polarity detection and thus causes a problem with regard to the successful continuation of compensation. The phenomenon is analysed in detail, along with its dependence on different factors. The proposed concept is validated in digital simulation and also through experimental verification. The study also recommends the possible correction to be incorporated in view of such zero-crossing shift for achieving proper compensation, especially in case of current-sensor-less compensation techniques.
Kwartety smyczkowe Hanny Kulenty. Pamięć gatunku a współczesne środki ekspresji
Authors: Nowak Anna 
Published: March 2023

ABSTRACTIn the work of Hanna Kulenty, a string quartet appears as a significant form of artistic expression. Its successive incarnations (6 quartets created in 1983-2014) illustrate the evolution of the musical language of composers, her approach to the problem of form, time, space, and sound. The article is an attempt to capture the idiomatic features of this music, presented in the context of Bakhtin’s theory of genre as a representative of creative memory, and to indicate the place of quartets in contemporary chamber music by Polish composers.
Association of OPRM1, MIR23B, and MIR107 genetic variability with acute pain, chronic pain and adverse effects after postoperative tramadol and paracetamol treatment in breast cancer
Authors: Vidic Zala , Goricar Katja , Strazisar Branka , Besic Nikola , Dolzan Vita 
Published: March 2023

Abstract

Background
Tramadol is an opioid analgesic often used for pain management after breast cancer surgery. Its analgesic activity is due to the activation of the μ-opioid receptor, encoded by the OPRM1 gene. This study investigated the association of genetic variability in OPRM1 and its regulatory miRNA genes with outcomes of tramadol/paracetamol treatment after breast cancer surgery with axillary lymphadenectomy.

Patients and methods
The study included 113 breast cancer patients after breast cancer surgery with axillary lymphadenectomy treated with either 75/650 mg or 37.5/325 mg of tramadol with paracetamol for pain relief within the randomized clinical trial KCT 04/2015-DORETAonko/si at the Institute of Oncology Ljubljana. All patients were genotyped for OPRM1 rs1799971 and rs677830, MIR23B rs1011784, and MIR107 rs2296616 using competitive allele-specific PCR. The association of genetic factors with acute and chronic pain as well as adverse effects of tramadol treatment was evaluated using logistic regression, Fisher’s exact test, and Mann-Whitney test.

Results
The investigated OPRM1 related polymorphisms were not associated with acute pain assessed with the VAS scale within four weeks after surgery (all P > 0.05). Carriers of at least one polymorphic OPRM1 rs1799971 allele had a higher risk of constipation in the first four weeks after surgery compared to non-carriers (OR = 4.5, 95% CI = 1.6–12.64, P = 0.004). Carriers of at least one polymorphic OPRM1 rs677830 allele had a higher risk of constipation after third week of tramadol treatment (OR = 3.11, 95% CI = 1.08–8.89, P = 0.035). Furthermore, carriers of two polymorphic MIR23B rs1011784 alleles had a higher risk of nausea after 28 days of tramadol treatment (OR = 7.35, 95% CI = 1.27–42.6, P = 0.026), while heterozygotes for MIR107 rs2296616 allele had a lower risk of nausea after 21 days of tramadol treatment (OR = 0.21, 95% CI = 0.05–0.87, P = 0.031). In carriers of two polymorphic MIR107 rs2296616 alleles, chronic pain was significantly more common than in carriers of two wild-type alleles (P = 0.004). Carriers of at least one polymorphic MIR23B rs1011784 allele experienced more neuropathic pain after adjustment for tramadol dose (OR = 2.85, 95% CI = 1.07–7.59, P = 0.036), while carriers of at least one polymorphic OPRM1 rs677830 allele experienced less neuropathic pain compared to carriers of two wild-type alleles (OR = 0.38, 95% CI = 0.15–0.99, P = 0.047).

Conclusions
Genetic variability of OPRM1 and genes coding for miRNAs that could affect OPRM1 expression may be associated with adverse effects of tramadol/paracetamol treatment as well as with chronic and neuropathic pain after breast cancer surgery with axillary lymphadenectomy.
CT-guided 125I brachytherapy for hepatocellular carcinoma in high-risk locations after transarterial chemoembolization combined with microwave ablation: a propensity score-matched study
Authors: Chen Zixiong , Fu Xiaobo , Qiu Zhenkang , Mu Maoyuan , Jiang Weiwei , Wang Guisong , Zhong Zhihui , Qi Han , Gao Fei 
Published: March 2023

Abstract

Background
This study aimed to evaluate the safety and efficacy of 125I brachytherapy combined with transarterial chemoembolization (TACE) and microwave ablation (MWA) for unresectable hepatocellular carcinoma (HCC) in high-risk locations.

Patients and methods
After 1:2 propensity score matching (PSM), this retrospectively study analyzed 49 patients who underwent TACE +MWA+125I brachytherapy (group A) and 98 patients who only received TACE +MWA (group B). The evaluated outcomes were progression-free survival (PFS), overall survival (OS), and treatment complications. Cox proportional hazards regression analysis survival was used to compare the two groups.

Results
The patients in group A showed a longer PFS than group B (7.9 vs. 3.3 months, P = 0.007). No significant differences were observed in median OS between the two groups (P = 0.928). The objective response rate (ORR), disease control rate of tumors in high-risk locations, and the ORR of intrahepatic tumors were 67.3%, 93.9%, and 51.0%, respectively, in group A, and 38.8%, 79.6% and 29.6%, respectively, in group B (P < 0.001, P = 0.025 and P = 0.011, respectively). TACE-MWA-125I (HR = 0.479, P < 0.001) was a significant favorable prognostic factor that affected PFS. The present of portal vein tumor thrombosis was an independent prognostic factor for PFS (HR = 1.625, P = 0.040). The Barcelona clinic liver cancer (BCLC) stage (BCLC C vs. B) was an independent factor affecting OS (HR = 1.941, P = 0.038). The incidence of complications was similar between the two groups, except that the incidence of abdominal pain was reduced in the group A (P = 0.007).

Conclusions
TACE-MWA-125I resulted in longer PFS and better tumor control than did TACE-MWA in patients with unresectable hepatocellular carcinoma in high-risk locations.
Iatrogenic Acute Aortic Dissection Complicating Coronary Catheterization
Authors: Macovei Liviu , Adoamnei Marius , Dumitrescu Irina , Panţiru Raluca-Mihaela , Năstasă Dan , Sascău Radu Andy , Stătescu Cristian 
Published: March 2023

Abstract
Coronary dissection extending to the ascending aorta is an uncommon complication of invasive coronary procedures which carries a life-threatening risk. The performance of percutaneous coronary intervention (PCI) at centers without emergency surgical instruments has increased awareness of potential complications. We report a case of iatrogenic aortocoronary dissection in a patient admitted with acute myocardial infarction (AMI) who was treated during angioplasty.
The responsible mechanism for the occurrence of aortic dissection during PCI remains to be discovered. In this case, brisk sealing of the entry site of the dissection with a stent to prevent extension of the aortic dissection appears to be safe and feasible, with good short- and long-term outcomes.