bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Quinquennial Review of Potent LSD1 Inhibitors Explored for the
Treatment of Different Cancers, with Special Focus on SAR Studies
Authors: Sheikh Khursheed Ahmad , Iqubal Ashif , Alam Mohammad Mumtaz , Akhter Mymoona , Khan Mohammad Ahmed , Ehtaishamul Haque Syed , Parvez Suhel , Jahangir Umar , Amir Mohammad , Khanna Suruchi , Shaquiquzzaman Mohammad 
Published: January 2023

Abstract:
Cancer bears a significant share of global mortality. The enzyme Lysine Specific
Demethylase 1 (LSD1, also known as KDM1A), since its discovery in 2004, has
captured the attention of cancer researchers due to its overexpression in several cancers
like acute myeloid leukaemia (AML), solid tumours, etc. The Lysine Specific Demethylase
(LSD1) downregulation is reported to have an effect on cancer proliferation, migration,
and invasion. Therefore, research to discover safer and more potent LSD1 inhibitors
can pave the way for the development of better cancer therapeutics. These efforts have resulted
in the synthesis of many types of derivatives containing diverse structural nuclei.
The present manuscript describes the role of Lysine Specific Demethylase 1 (LSD1) in
carcinogenesis, reviews the LSD1 inhibitors explored in the past five years and discusses
their comprehensive structural activity characteristics apart from the thorough description
of LSD1. Besides, the potential challenges, opportunities, and future perspectives in
the development of LSD1 inhibitors are also discussed. The review suggests that tranylcypromine
derivatives are the most promising potent LSD1 inhibitors, followed by triazole
and pyrimidine derivatives with IC50 values in the nanomolar and sub-micromolar
range. A number of potent LSD1 inhibitors derived from natural sources like resveratrol,
protoberberine alkaloids, curcumin, etc. are also discussed. The structural-activity relationships
discussed in the manuscript can be exploited to design potent and relatively
safer LSD1 inhibitors as anticancer agents.
The Effect of Auriculotherapy During Active Phase and the Use of Oxytocin
During Labor in Nulliparous Women-A Randomized Clinical Trial
Authors: Vakilian Katayon , Ghaemmaghami Mehrnoosh , Sheikhganbari Narges , Shabani Fatemeh , Vahedi Masoomeh 
Published: January 2023

Background:
Since there was no study on the effect of auriculotherapy on reducing the use
of oxytocin and labor length, the present study is aimed to investigate this issue.

Methods:
The present study was a randomized clinical trial with two parallel arms, without blinding,
which was performed on 93 nulliparous women. Setting this study was done in one of the referral hospitals
in Qom, Iran. The samples were randomly assigned to two groups: oxytocin (n = 47) or auriculotherapy
and oxytocin (n = 46). After hospitalization of mothers in the active phase, in one group, 10-
unit oxytocin was administered for augmentation, and in the second intervention group, the auriculotherapy
technique, in addition to oxytocin, was performed. the master points zero, Shenmen, endocrine,
thalamic, uterine, prostaglandin points, vagina on the earlobe area. The points were stimulated
with the Pointer Plus electric device for 30 seconds, and 60 minutes later, the other ear was stimulated.
The results were analyzed by SPSS 22, T-test statistical analysis, and Chi-square test.

Results:
Regarding the main purpose of the study, the results showed that the length of the active
phase indicated a significant decrease in the auriculotherapy group compared to the oxytocin group
(244.86 ± 64.19 vs. 284 ± 62.75, p = 0.01). The other purpose of the study showed that the mean of
oxytocin consumption significantly decreased in the auriculotherapy group.

Conclusion:
It seems that auriculotherapy is an appropriate alternative method for labor augmentation.
Gastroenteritis Forecasting Assessing the Use of Web and Electronic Health Record Data With a Linear and a Nonlinear Approach: Comparison Study
Authors: Poirier Canelle , Bouzillé Guillaume , Bertaud Valérie , Cuggia Marc , Santillana Mauricio , Lavenu Audrey 
Published: January 2023

Background
Disease surveillance systems capable of producing accurate real-time and short-term forecasts can help public health officials design timely public health interventions to mitigate the effects of disease outbreaks in affected populations. In France, existing clinic-based disease surveillance systems produce gastroenteritis activity information that lags real time by 1 to 3 weeks. This temporal data gap prevents public health officials from having a timely epidemiological characterization of this disease at any point in time and thus leads to the design of interventions that do not take into consideration the most recent changes in dynamics.

Objective
The goal of this study was to evaluate the feasibility of using internet search query trends and electronic health records to predict acute gastroenteritis (AG) incidence rates in near real time, at the national and regional scales, and for long-term forecasts (up to 10 weeks).

Methods
We present 2 different approaches (linear and nonlinear) that produce real-time estimates, short-term forecasts, and long-term forecasts of AG activity at 2 different spatial scales in France (national and regional). Both approaches leverage disparate data sources that include disease-related internet search activity, electronic health record data, and historical disease activity.

Results
Our results suggest that all data sources contribute to improving gastroenteritis surveillance for long-term forecasts with the prominent predictive power of historical data owing to the strong seasonal dynamics of this disease.

Conclusions
The methods we developed could help reduce the impact of the AG peak by making it possible to anticipate increased activity by up to 10 weeks.
Characterizing Heated Tobacco Products Marketing on Instagram: Observational Study
Authors: Chen Jiarui , Xue Siyu , Xie Zidian , Li Dongmei 
Published: January 2023

Background
Heated tobacco products (HTPs), including I Quit Ordinary Smoking (IQOS), are new tobacco products that use an electronic device to heat compressed tobacco leaves to generate an aerosol for consumers to inhale. Marketing of HTPs is prevalent on Instagram, a popular social media platform.

Objective
This study aims to characterize posts related to HTPs on Instagram and their associations with user engagement.

Methods
Through the Instagram application programming interface, 979 Instagram posts were collected using keywords related to HTPs, such as “IQOS” and “heat-not-burn.” Among them, 596 posts were related to IQOS and other HTP marketing. The codebook was developed from a randomly selected 200 posts on the post content by hand coding, which was applied to the remaining 396 Instagram posts. Summary statistics were calculated, and statistical hypothesis testing was conducted to understand the popularity of Instagram posts on HTPs. Negative binomial regression models were applied to identify Instagram post characteristics associated with user engagement (eg, count).

Results
Among Instagram posts related to HTP marketing (N=596), “product display” was dominant (n=550, 92.28%), followed by “brand promotion” (n=41, 6.88%), and “others” (n=5, 0.84%). Among posts within “product display,” “device only” was the most popular (n=338, 61.45%), followed by “heatstick only” (n=80, 14.55%), “accessory” (n=66, 12%), “device and heatstick” (n=56, 10.18%), and “capsule” (n=10, 1.82%). A univariate negative binomial regression model with pairwise comparisons across “product display” types showed that the number of likes for posts with HTP heatsticks was significantly lower compared to posts with HTP devices, accessories, and device-heatstick sets. Multivariate negative binomial regression models showed that HTP-related Instagram posts with a model or lifestyle elements (;=.60, 95% CI 0.36-0.84) or without obvious product advertising information (=.69, 95% CI 0.49-0.89) received more likes.

Conclusions
It is shown that posts with product displays were dominant among HTP-related posts on Instagram. Posts with model or lifestyle elements are associated with high user engagement, which might be one of the web-based marketing strategies of HTPs.
Growing income-related disparities in cardiovascular hospitalizations among people with diabetes, 1995 to 2019: population-based study
Authors: Shah Baiju R. , Ke Calvin , L. Lipscombe Lorraine , Weisman Alanna , L. Booth Gillian 
Published: January 2023

<p> </p>
<p>Objective: Cardiovascular risk reduction is an important focus in the management of people with diabetes. Although event rates have been declining over the long-term, they have been observed to plateau or reverse in recent years. Furthermore, the impact of income-related disparities in cardiovascular events is unknown. The objective of this study was to evaluate age-, sex- and income-related trends in cardiovascular hospitalization rates among people with diagnosed diabetes.</p>
<p>Research Design and Methods: We calculated rates of hospitalization for acute myocardial infarction, stroke, heart failure and lower extremity amputation in annual cohorts of the entire population of Ontario, Canada with diagnosed diabetes, from 1995 to 2019. Event rates were stratified by age, sex and income level.</p>
<p>Results: We studied nearly 1.7 million people with diabetes. The rate of acute myocardial infarction declined throughout the 25-year study period (p<0.0001), such that the rate in 2019 was less than half the rate in 1995. Rates of stroke (p<0.0001), heart failure (p<0.0001) and amputation (p<0.0001) also changed over time, but hospitalization rates stabilized through the 2010s. This apparent stabilization concealed a growing income-related disparity: wealthier patients showed continued declines in rates of these outcomes during the decade, whereas rates for lower-income patients increased (p for interaction <0.0001 for all 4 outcomes). </p>
<p>Conclusions: During a quarter-century of follow-up, cardiovascular hospitalization rates among people with diabetes fell. However, the apparent stabilization in rates of stroke, heart failure and amputation in recent years masks the fact that rates have risen for lower-income individuals. </p>
Inovasi Pelayanan Aplikasi Whatsapp Pada Masa Pandemi Covid-19 Untuk Pembuatan E-KTP di Kecamatan Muara Bangkahulu Kota Bengkulu
Authors: Setiawan Irfan , Catur Nur Rahayu Dewi , PS Daffa Ulhaq 
Published: January 2023

Kondisi dunia saat ini dihebohkan dengan hadirnya virus yang mengancam kesehatan setiap manusia. Virus ini memiliki akibat yang sangat fatal yaitu dapat menyebabkan kematian. Penyebaran COVID-19 yang sangat meresahkan membuat pergerakan disegala bidang mengalami terhambat, untuk mengurangi banyaknya orang yang terpapar maka harus diberlakukannya 5M terdiri dari: memakai masker, mencuci tangan, menjaga jarak, menjauhi kerumunan dan mengurangi mobilitas. Bhakti Karya Praja IPDN Tahun 2021 yang dilakukan oleh penulis memiliki tujuan yaitu untuk membantu Kecamatan Muara Bangkahulu Kota Bengkulu dalam melakukan inovasi pelayanan yang mengharuskan adanya pembatasan interaksi pihak kecamatan dan masyarakat. Penelitian ini menggunakan metode pendekatan kualitatif dengan pengumpulan data menggunakan teknik observasi, wawancara dan dokumentasi dan analisis data menggunakan tiga tahap yaitu reduksi data, penyajian data, dan penarikan kesimpulan. Pelayanan pembuatan e-KTP masih dilakukan secara manual oleh Kecamatan Muara Bangkahulu, dibutuhkan adanya inovasi pelayanan baru yaitu dengan menambah pelayanan online, maka pada pelaksanaan BKP penulis mengajukan pelayanan online berbasis whatsapp pada pembuatan e-KTP guna memudahkan pelayanan yang diberikan oleh pihak Kecamatan Muara Bangkahulu kepada masyarakat dan untuk menghindari penyebaran COVID-19. Hasil penelitian menunjukkan bahwa gagasan penulis kepada Kecamatan Muara Bangkahulu dapat diterima oleh Camat Mura Bangkahulu dan jajarannya dan program ini sudah berjalan cukup baik.
Psikoedukasi sebagai Solusi terhadap Penyesuaian Siswa SMA Al Islam 1 Surakarta terhadap Pembelajaran Campuran saat Pandemi
Authors: Salsabilla Soraya Berliana , Elsa Azhari Hayuning Samudra  , Alifina Puspanoti  , Afifah Nurfitria Ramadhani  , Lisnawati Ruhaena  
Published: January 2023

Pembelajaran campuran atau blended learning adalah model pembelajaran yang memadukan antara pembelajaran daring dan luring. Model ini digunakan setelah munculnya kebijakan baru di masa covid-19 ini. Namun tentu saja tetap ada kendala-kendala yang dialami ketika menerapkan blended learning ini. Tujuan pengabdian yang kami lakukan yakni untuk memberikan psikoedukasi sebagai solusi terhadap penyesuaian siswa terhadap pembelajaran campuran. Subjek yang digunakan yakni siswa kelas X SMA Al Islam yang berjumlah 70 orang. Teknik pengumpulan data menggunakan observasi dan penyebaran angket kuisioner dengan hasil yakni psikoedukasi dapat membantu siswa dalam menyelesaikan permasalahan yang ada ketika pembelajaran campuran berlangsung.
PENGARUH IMPLEMENTASI KEBIJAKAN PENGELOLAAN SAMPAH TERHADAP PARTISIPASI MASYARAKAT DI KOTA SUKABUMI
Authors: Puspita Khairunnisa Alya , Rachmawati Ike , Sampurna Hegia 
Published: January 2023

Policy implementation is a policy process that involves the several actor, one of which is citizen. Citizens participation turn out to the success and accuracy affecting factors of policy to achieving goals. However, the enacthment of waste management policy in Sukabumi City has not given a result in the amount of waste decrease in every year. It could be due to implementations affecting to citizens participation. Afterwards, there are gap between two results in previous researches related to the influence of waste management policy implementation on public participation which it need more research. This research aims to known the waste management policy implementation in Sukabumi City, Citizens participation on waste management in Sukabumi City, and the influence of policy implementation and Citizens participation in Sukabumi City. George Edward Theory used to quantify the policy implementation, there are 4 dimension inculdings communication, resources, disposition, and bureaucratic structure. Meanwhile Citizens Participation used Keith Davis Theory, there are 3 idea inculdings mental and emotional involvement, motivation to contribution, and responsibility. This resarched used quantitative by distributing questionnaries to the public. As for the number of samples are 100 respondents which is devided into 7 Sukabumi City Districts. The questionnaries are valid and reliable. The result of this research are the waste management policy implementation and Citizens participation have high categorized. Then, there is the influence of waste management policy implementation based on communication, resources, disposition, and bureaucratic structure on Citizens participation with 14.8% of R­2.

Keywords: Policy Implementation, Citizens Participation, Waste Management, Sukabumi City.
STRATEGI BERTAHAN DAN PEMASARAN ONLINE DI MASA PANDEMI COVID-19 UKM KOTA BANDUNG STUDI KASUS USAHA KECIL RAJUT
Authors: Abdurohim Dindin , Susila Yanti , Maula Novendra Afief 
Published: January 2023

Penelitian ini bertujuan untuk mendeskripsikan dan menganalisis strategi bertahan dan strategi pemasaran online usaha kecil rajut di masa pandemi COVID-19 di Bandung. Penelitian ini menggunakan metode kualitatif dengan pendekatan studi kasus. Data diperoleh dengan mewawancarai pelaku usaha rajut dan pihak terkait sebagai informan kunci. Hasil penelitian menunjukkan bahwa pandemi COVID-19 berdampak negatif pada usaha kecil rajut di sentra rajut kota bandung. Sebagai Langkah strategi di tengah pandemi, para pelaku bisnis menggunakan strategi bertahan, dengan cara tidak menaikkan harga jual, melainkan mengurangi target keuntungan, dalam strategi pemasaran online pelaku usaha kecil rajut menggunakan strategi : e-commerce, pemasaran digital, peningkatan kualitas produk dan layanan, serta hubungan pelanggan. Implementasi strategi tersebut didorong oleh semangat kewirausahaan, fleksibilitas, tanggap terhadap perubahan dan perkembangan teknologi, serta kemampuan berkolaborasi dengan berbagai pemangku kepentingan. Penelitian ini menunjukkan bahwa usaha kecil yang menerapkan strategi bertahan dan pemasaran online mampu bertahan dan meningkatkan kinerja bisnis.
PELATIHAN IDENTIFIKASI FAUNA DAN FLORA UNTUK WARGA SEKITAR TAMAN NASIONAL GUNUNG MERBABU DAN MERAPI
Authors: Andika Ignatius Putra , Yulianti L. Indah Murwani , Setyobudi Vincencius Tri , Yuda Ign. Pramana 
Published: January 2023

Taman nasional adalah usaha pemerintah untuk melestarikan biodiversitas/keanekaragaman hayati di Indonesia dan keterlibatan masyarakat di sekitarnya sangat penting dalam usaha ini. Salah satu kegiatan yang penting adalah mengenal fauna dan flora yang ada di dalam kawasan ini. Usaha mengenal ini bisa dimulai dari berbagai taksa beserta peran. Selain itu, tersedianya berbagai teknologi informasi untuk menjalankan usaha ini sekaligus belajar adalah kesempatan yang baik untuk menyukseskan kegiatan ini. Oleh karena itu, kegiatan pengabdian yang dilakukan bertujuan untuk mengenalkan berbagai taksa dan usaha membudidayakan anggrek. Kegiatan dimulai dengan berdiskusi dengan staff taman nasional dan warga untuk membahas materi. Setelah itu, kegiatan disampaikan dengan pematerian dan dilanjutkan dengan kegiatan hands-on. Peserta mengikuti kegiatan dengan antusias dan menunjukkan bahwa materi sebagian besar mudah untuk diikuti. Setelah kegiatan, diketahui bahwa pendampingan lanjutan masih diperlukan untuk terus mengasah keterampilan warga.
IMPROVING GRADE V STUDENTS’ VOCABULARY ACHIEVEMENT THROUGH FLASH CARDS
Authors: Sitorus Sabatini , Siregar Masitowarni 
Published: January 2023

ABSTRACT This study attempts to increase students’ vocabulary achievement by using flash cards. The objective of the study is to investigate whether the using of flash card can improve students’ vocabulary achievement. This study conduct by applying Classroom Action Research which was carried out in two cycles in six meetings. The subject of this study of SD Negeri 174559 Siraituruk, Porsea which consisted of 34 students. For collecting data, the instruments used were quantitative (vocabulary test) and qualitative data (interview sheet, observation sheet, and diary notes. Based on the data, it was found that the mean of the second cycle (80, 44) is higher than the mean of first cycle (64, 85) and pre-test (44, 41). Based on interview sheet, observation sheet and diary notes, it was found thee students were more active and more enthusiastic during the teaching learning process in the second cycle than the first one. It was concluded that teaching vocabulary by using flash cards can improve the students’ vocabulary achievement. Keywords : Flash Cards, Vocabulary, Action Research
CSR SPENDING IN INDIA: EXPLORING THE LINKAGES WITH BUSINESS GROUP AFFILIATION AND PRODUCT PORTFOLIO DIVERSIFICATION
Authors: Potharla Srikanth , Hiranya Dissanayake  , Balachandram Amirishetty  
Published: January 2023

The present study aims to examine the influences of group affiliations status on the CSR spending of a firm and also to test how the group size and interaction of group size and product portfolio diversification influences the CSR spending. The sample of the present study covers 1,513 Indian firms coming under the ambit of CSR reporting, represented through the unbalanced panel data set of 4,459 firm-years from the year 2014 to 2019. The baseline model regresses CSR spending on the group affiliation status and set of controlling variables which are having the impact on CSR spending by using panel least squares regression model. The baseline model is extended to test the impact of group size and interaction of group size and product portfolio diversification on the CSR spending. Industry variations with regard to CSR spending are controlled by introducing industry fixed effects into the regression model. The findings of the study reveal significant positive impact of group affiliation status on CSR spending. The results are also robust to the group size effect and the interaction effect of group size and product portfolio diversification. The findings are supporting stewardship theory and socio—emotional wealth creation view of the group affiliated firm which asserts that group affirms experience variety of stakeholder demands and social issues. Building social reputation through CSR activities will be helpful in handling such situations. The findings also proved that larger group firms with wider product diversification are more encouraged towards CSR spending. This is the first study which tests the impact of group size and also the interaction of group size and product portfolio diversification on CSR spending. The study contributes to the literature on how the ownership style, especially, group affiliation status, influences the social engagement of a firm
ІДЕОЛОГІЧНИЙ КОНТРОЛЬ СТАЛІНСЬКОГО РЕЖИМУ ЗА ІНТЕЛІГЕНЦІЄЮ В УКРАЇНСЬКІЙ РСР: 1945 – 1953 рр.
Authors: БАРАН Володимир 
Published: January 2023

У статті проаналізовано зміст, головні форми і методи ідеологічного контролю за інтелігенцією,, що здійснювався сталінським режимом в Українській РСР у 1945 – 1953 рр. Мета статті – з’ясувати роль органів цензури і публічних викривальних кампаній, що отримали назву “ждановщини”, у встановленні жорсткого політико-ідеологічного контролю за літературою, мистецтвом і наукою в УРСР, за діяльністю творчої та наукової інтелігенції республіки. Методологія: стаття базується на теорії тоталітаризму та принципах, сформульованих Карлом Фрідріхом; у ній використовуються традиційні загальнонаукові та спеціальні історичні методи (історико-генетичний, історико-системний, історико-порівняльний, історико-типологічний), принципи авторської об’єктивності, історизму, верифікації. Наукова новизна полягає у залученні оригінального документального матеріалу з центральних державних архівів України та Російської Федерації. Висновки. Ідеологічний контроль був однією з базових ознак радянського тоталітаризму, дієвим інструментом контролю влади за творчою і науковою інтелігенцією, усім суспільним життям. Аналіз архівних документів свідчить, що ключовою ланкою у системі ідеологічного контролю залишалася цензура, яка блокувала офіційні канали масової комунікації і не допускала жодних відхилень від прийнятих ідейних стандартів. Також у перші післявоєнні роки сталінський режим проводив численні викривальні кампанії, по суті – політико-ідеологічні чистки в літературі, мистецтві й науці, звинувачуючи українських митців і вчених у “національній обмеженості”, в “українському буржуазному націоналізмі”. Такий контроль за діяльністю інтелігенції, за всіма сферами духовного життя забезпечував ідеологічну монополію комуністичної партії в суспільстві.