bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural characterisation and pH-dependent preference of pyrrole cross-link isoforms from reactions of oxoenal with cysteine and lysine side chains as model systems
Authors: Muńko Malwina , Ciesielska Karolina , Hoffmann Marcin , Pluskota-Karwatka Donata 
Published: July 2023

AbstractIn this study, we subjected 5,5-diethoxy-4-oxopent-2-enal (DOPE), a model amino acids cross-linking reagent, to reactions with N-acetylcysteine (Ac-Cys) and Nα-acetyllysine (Ac-Lys), and identified three pyrrole cross-links. The compounds were isolated and their structures were rigorously determined by spectrometric and spectroscopic methods, including 2D NMR experiments. The use of 2D NMR spectroscopy was crucial to determine the position of the substituents in the pyrrole rings. The products were identified as 2,4-, 2,3-, and 2,5-substituted pyrroles. The data obtained from their structural characterisation can help similar studies on amino acids modifications induced by analogous bifunctional carbonyl compounds. Our results show that the study of pathways in which model electrophiles modify amino acids may be helpful for similar studies dealing with identification of structural changes in cysteine- and lysine-containing proteins associated with oxidative stress.
Are comorbidities associated with the cytokine/chemokine profile of persistent apical periodontitis?
Authors: Agger Anne Eriksson , Reseland Janne Elin , Hjelkrem Erik , Lian Aina-Mari , Hals Else K. Breivik , Zandi Homan , Sunde Pia Titterud 
Published: July 2023

AbstractObjectivesThis study aimed to identify disease-related markers in persistent apical periodontitis (PAP) biopsies and examine whether these were associated with comorbidities like rheumatoid arthritis (RA) and cardiovascular diseases (CVD).Materials and methodThe levels of the cytokines/chemokines GM-CSF, IFN-γ, IL-2, IL-6, IL-9, IL-10, IL-13, IL-15, IL-17E/IL-25, IL-21, IL-23, IL-27, IL-28A/IFN -λ2, IL-33, MIP-3α/CCL20, and TNF-α were determined in lesions from patients with PAP (n = 20) and compared to healthy bone samples (n = 20).ResultsWe identified eleven cytokines to be differently expressed, and among them, IL-2, IL-6, IL-17E, IL-21, and IL-27 appeared to drive the discrepancy between the disease and healthy groups. The levels of T follicular helper (Tfh) cell promoting cytokines (IL-21, IL-6, IL-27) were enhanced while T helper (Th) 1 cell promoting cytokine (IL-2), Th2 cell promoting cytokine (IL-13), and Th17 cell promoting cytokine (IL-17E) were reduced in the PAP group. The data also indicate that Tfh cell differentiation (IL-21), along with Th1 (GM-CSF, IFNγ), Th2 (IL-13), and Th17 (GM-CSF) cell differentiation, might be increased in the subpopulation of patients suffering from RA, whereas no differences were found in patients with CVD.ConclusionsLevels of cytokines/chemokines in PAP were identified, and cluster analyzes indicated that these markers may be associated with the differentiation of different T cell populations. Patients with PAP and RA comorbidities showed elevated levels of markers reinforcing this association.Clinical relevanceMolecular analyses of PAP may result in identification of prognostic markers.
Short-term effects of an elimination diet and healthy diet in children with attention-deficit/hyperactivity disorder: a randomized-controlled trial
Authors: Huberts-Bosch Annick , Bierens Margreet , Ly Verena , van der Velde Jessica , de Boer Heleen , van Beek Gerry , Appelman Danielle , Visser Sacha , Bos Lisa H. P. , Reijmers Lisa , van der Meer Jolanda , Kamphuis Niki , Draaisma Jos M. T. , Donders Rogier , van de Loo-Neus Gigi H. H. , Hoekstra Pieter J. , Bottelier Marco , Arias-Vasquez Alejandro , Klip Helen , Buitelaar Jan K. , van den Berg Saskia W. , Rommelse Nanda N. 
Published: July 2023

AbstractAn Elimination Diet (ED) may be effective in reducing symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD), but has never been compared to an active control condition [i.e., Healthy Diet (HD)]. In a two-armed RCT, a total of N = 165 children (5–12 years) with ADHD were randomized by means of minimization (1:1) to either an ED (N = 84) or HD (N = 81) within two Dutch child and adolescent psychiatry centers. The design included a non-randomized comparator arm including N = 58 children being treated with Care as Usual (CAU). Treatment allocation was unblinded. The primary outcome was a 5-point ordinal measure of respondership based on a combination of parent and teacher ratings on ADHD and emotion regulation, determined after 5 weeks of treatment. Ordinal regression analyses were done on an intention-to-treat basis. Fewer ED (35%) than HD (51%) participants showed a partial to full response, despite overall good-to-excellent treatment adherence (> 88%) and comparable high parental prior believes. A younger age and higher problem severity predicted a better respondership. CAU-preferring participants responded more often favorably (56%) compared to ED—but not HD—participants. Small-to-medium improvements in physical health (blood pressure, heart rate, and somatic complaints) were found in response to ED/HD versus decrements in response to CAU (74% received psychostimulants). The lack of superiority of the ED versus HD suggests that for the majority of children, dietary treatment response is not rooted in food-allergies/-sensitivities. The comparable results for treatment with HD and CAU are remarkable given that CAU participants were probably ‘easier to treat’ than HD (and ED) participants with proportionally fewer with a (suboptimal/non-response to) prior treatment with medication (4% versus 20%). Further assessment of long-term effects is needed to evaluate the potential place of dietary treatment within clinical guidelines. The trial is closed and registered in the Dutch trial registry, number NL5324 (https://www.onderzoekmetmensen.nl/en/trial/25997).
Comparing behavioural outcomes in children born extremely preterm between 2006 and 1995: the EPICure studies
Authors: Larsen Jennifer , Kochhar Puja , Wolke Dieter , Draper Elizabeth S. , Marlow Neil , Johnson Samantha 
Published: July 2023

Abstract
Background
Children born extremely preterm (EP) are at increased risk of neurocognitive and behavioural morbidity. Here, we investigate whether behavioural outcomes have changed over time concomitant with increasing survival following EP birth.

Methods
Comparison of outcomes at 11 years of age for two prospective national cohorts of children born EP in 1995 (EPICure) and 2006 (EPICure2), assessed alongside term-born children. Behavioural outcomes were assessed using the parent-completed Strengths and Difficulties Questionnaire (SDQ), DuPaul Attention-Deficit/Hyperactivity Disorder Rating Scale (ADHD-RS), and Social Communication Questionnaire (SCQ).

Results
In EPICure, 176 EP and 153 term-born children were assessed (mean age: 10.9 years); in EPICure2, 112 EP and 143 term-born children were assessed (mean age: 11.8 years). In both cohorts, EP children had higher mean scores and more clinically significant difficulties than term-born children on almost all measures. Comparing outcomes for EP children in the two cohorts, there were no significant differences in mean scores or in the proportion of children with clinically significant difficulties after adjustment for confounders. Using term-born children as reference, EP children in EPICure2 had significantly higher SDQ total difficulties and ADHD-RS hyperactivity impulsivity z-scores than EP children in EPICure.

Conclusions
Behavioural outcomes have not improved for EP children born in 2006 compared with those born in 1995. Relative to term-born peers, EP children born in 2006 had worse outcomes than those born in 1995. There is an ongoing need for long-term clinical follow-up and psychological support for children born EP.
Prevalence, in-hospital mortality, and factors related to neurogenic pulmonary edema after spontaneous subarachnoid hemorrhage: a systematic review and meta-analysis
Authors: Guo Lei , Yang Xu , Yang Bo , Tang Guo , Li Chunling 
Published: July 2023

AbstractNeurogenic pulmonary edema (NPE) is a life-threatening and severe complication in patients with spontaneous subarachnoid hemorrhage (SAH). The prevalence of NPE varies significantly across studies due to differences in case definitions, study populations, and methodologies. Therefore, a precise estimation of the prevalence and risk factors related to NPE in patients with spontaneous SAH is important for clinical decision-makers, policy providers, and researchers. We conducted a systematic search of the PubMed/Medline, Embase, Web of Science, Scopus, and Cochrane Library databases from their inception to January 2023. Thirteen studies were included in the meta-analysis, with a total of 3,429 SAH patients. The pooled global prevalence of NPE was estimated to be 13%. Out of the eight studies (n = 1095, 56%) that reported the number of in-hospital mortalities of NPE among patients with SAH, the pooled proportion of in-hospital deaths was 47%. Risk factors associated with NPE after spontaneous SAH included female gender, WFNS class, APACHE II score ≥ 20, IL-6 > 40 pg/mL, Hunt and Hess grade ≥ 3, elevated troponin I, elevated white blood cell count, and electrocardiographic abnormalities. Multiple studies showed a strong positive correlation between the WFNS class and NPE. In conclusion, NPE has a moderate prevalence but a high in-hospital mortality rate in patients with SAH. We identified multiple risk factors that can help identify high-risk groups of NPE in individuals with SAH. Early prediction of the onset of NPE is crucial for timely prevention and early intervention.
Factors affecting spatial occupancy and local abundance of the Forest Thrush, Turdus lherminieri, in Guadeloupe forests
Authors: Jean-Pierre Aurélie , Loranger-Merciris G. , Saint-Louis L. J. , Cézilly F. 
Published: July 2023

AbstractThe Forest Thrush (FT), Turdus lherminieri, is a secretive, ground-dwelling forest bird species of conservation concern, endemic to only four Caribbean islands. Factors influencing habitat selection and abundance by FT have been seldom documented so far. We assessed variation in the presence and abundance of FT in various forested habitats in Guadeloupe. To that end, we deployed 5-camera-trap arrays over 14 days on 24 different survey stations resulting in 1680 trap days. We observed FT more frequently at camera trap stations where rainforest dominated, with local abundance declining with increasing canopy openness. Furthermore, temperature was the most important factor affecting the presence of FT at our study sites. FT was essentially diurnal, with some activity at dawn and dusk. We document for the first-time spatial co-occurrence between FT and potential mammal predators. FT co-occurred positively with rats and negatively with cats. Although FT is globally listed as near threatened by IUCN, the species the species appeared to be relatively abundant in Guadeloupe, possibly as a consequence of the suspension of hunting since 2014 and/or the almost total protection of the Guadeloupe tropical rainforest. We recommend the use of camera traps to improve knowledge for the conservation status of the species in other part of its area of distribution and to provide additional information on the potential impact of exotic predatory mammals.
Yoneda Lemma for Simplicial Spaces
Authors: Rasekh Nima 
Published: July 2023

AbstractWe study the Yoneda lemma for arbitrary simplicial spaces. We do that by introducingleft fibrationsof simplicial spaces and studying their associated model structure, thecovariant model structure. In particular, we prove arecognition principlefor covariant equivalences over an arbitrary simplicial space andinvarianceof the covariant model structure with respect to complete Segal space equivalences.
Regional and ethnic inequalities in Malaysian poverty dynamics
Authors: Rongen Gerton , Ahmad Zainab Ali , Lanjouw Peter , Simler Kenneth 
Published: July 2023

Abstract
This study employs a synthetic panel approach based on nationally-representative micro-level data to track poverty and income mobility in Malaysia in the period 2004–2016. On aggregate we observe large reductions in chronic poverty and increases in persistent economic security, but note that those who remain poor in 2016 are increasingly likely to be poor in a structural sense. Further, we find that poverty and income dynamics differ notably across geographic dimensions. Such disparities are most striking when we contrast affluent urban Peninsular Malaysia with poorer rural East Malaysia. Although there are important differences in welfare levels between the main ethnic groups in Malaysia, we observe that mobility trends generally point in the same direction. While our findings show that there is still scope for poverty reduction through the reduction of inter-ethnic inequalities, we underscore the importance of taking regional inequalities into greater account when it comes to ensuring a fairer distribution of socioeconomic opportunities for poor and vulnerable Malaysians. Hence, addressing chronic poverty is likely to require additional attention to less developed geographic areas, as a complement to the largely ethnicity-based policies that have historically played a dominant role.
Trajectorial Dissipation of $${\Phi }$$-Entropies for Interacting Particle Systems
Authors: Jahnel Benedikt , Köppl Jonas 
Published: July 2023

AbstractA classical approach for the analysis of the long-time behaviour of Markov processes is to consider suitable Lyapunov functionals like the variance or more generally $$\Phi $$
Φ
-entropies. Via purely analytic arguments it can be shown that these functionals are indeed non-increasing in time under quite general assumptions on the process. We refine these classical results via a more probabilistic approach and show that dissipation is already present on the level of individual trajectories for spatially extended systems of infinitely many interacting particles with arbitrary underlying geometry and compact local spin spaces. This extends previous results from the setting of finite-state Markov chains or diffusions in $$\mathbb {R}^n$$

R

n

to an infinite-dimensional setting with weak assumptions on the dynamics.
Performance analysis of H2BR: HTTP/2-based segment upgrading to improve the QoE in HAS
Authors: Nguyen Minh , Amirpour Hadi , Tashtarian Farzad , Timmerer Christian , Hellwagner Hermann 
Published: July 2023

AbstractHTTP Adaptive Streaming (HAS) plays a key role in over-the-top video streaming with the ability to reduce the video stall duration by adapting the quality of transmitted video segments to the network conditions. However, HAS still suffers from two problems. First, it incurs variations in video quality because of throughput fluctuation. Adaptive bitrate (ABR) algorithms at the HAS client usually select a low-quality segment when the throughput drops to avoid stall events, which impairs the Quality of Experience (QoE) of the end-users. Second, many ABR algorithms choose the lowest-quality segments at the beginning of a video streaming session to ramp up the playout buffer early on. Although this strategy decreases the startup time, clients can be annoyed as they have to watch a low-quality video initially. To address these issues, we introduced the H2BR technique (H TTP/2-B ased R etransmission) (Nguyen et al. 33) that utilizes certain features of HTTP/2 (including server push, multiplexing, stream priority, and stream termination) for late transmissions of higher-quality versions of video segments already in the client buffer, in order to improve video quality. Although H2BR was shown to enhance the QoE, limited streaming scenarios were considered resulting in a lack of general conclusions on H2BR’s performance. Thus, this article provides a profound evaluation to answer three open questions: (i) how H2BR’s performance is impacted by parameters at the server side (i.e., various encoding specifications), at the network side (i.e., packet loss rate), and at the client side (i.e., buffer size) on the performance of H2BR; (ii) how H2BR outperforms other state-of-the-art approaches in different configurations of the parameters above; (iii) how to effectively utilize H2BR on top of ABR algorithms in various streaming scenarios. The experimental results show that H2BR’s performance increases with the buffer size and decreases with increasing packet loss rates and/or video segment duration. The number of quality levels can negatively or positively impact on H2BR’s performance, depending on the ABR algorithm deployed. In general, H2BR is able to enhance the video quality by up to 17% and 14% in scalable video streaming and in non-scalable video streaming, respectively. Compared with an existing retransmission technique (i.e., SQUAD Wang et al., ACM Trans Multimed Comput Commun Applic (TOMM) 13(3s): 45, 49), H2BR shows better results with more than 10% in QoE and 9% in the average video quality.
A universal quantum algorithm for weighted maximum cut and Ising problems
Authors: Kuete Meli Natacha , Mannel Florian , Lellmann Jan 
Published: July 2023

AbstractWe propose a hybrid quantum-classical algorithm to compute approximate solutions of binary combinatorial problems. We employ a shallow-depth quantum circuit to implement a unitary and Hermitian operator that block-encodes the weighted maximum cut or the Ising Hamiltonian. Measuring the expectation of this operator on a variational quantum state yields the variational energy of the quantum system. The system is enforced to evolve toward the ground state of the problem Hamiltonian by optimizing a set of angles using normalized gradient descent. Experimentally, our algorithm outperforms the state-of-the-art quantum approximate optimization algorithm on random fully connected graphs and challenges D-Wave quantum annealers by producing good approximate solutions. Source code and data files are publicly available (https://github.com/nkuetemeli/UQMaxCutAndIsing).
Determining the feasibility of characterising cellular senescence in human skeletal muscle and exploring associations with muscle morphology and physical function at different ages: findings from the MASS_Lifecourse Study
Authors: Habiballa Leena , Hruby Adam , Granic Antoneta , Dodds Richard M. , Hillman Susan J. , Jurk Diana , Passos João F. , Sayer Avan A. 
Published: July 2023

AbstractCellular senescence may be associated with morphological changes in skeletal muscle and changes in physical function with age although there have been few human studies. We aimed to determine the feasibility of characterising cellular senescence in skeletal muscle and explored sex-specific associations between markers of cellular senescence, muscle morphology, and physical function in participants from the MASS_Lifecourse Study. Senescence markers (p16, TAF (Telomere-Associated DNA Damage Foci), HMGB1 (High Mobility Group Box 1), and Lamin B1) and morphological characteristics (fibre size, number, fibrosis, and centrally nucleated fibres) were assessed in muscle biopsies from 40 men and women (age range 47–84) using spatially-resolved methods (immunohistochemistry, immunofluorescence, and RNA and fluorescence in situ hybridisation). The associations between senescence, morphology, and physical function (muscle strength, mass, and physical performance) at different ages were explored. We found that most senescence markers and morphological characteristics were weakly associated with age in men but more strongly, although non-significantly, associated with age in women. Associations between senescence markers, morphology, and physical function were also stronger in women for HMGB1 and grip strength (r = 0.52); TAF, BMI, and muscle mass (r > 0.4); Lamin B1 and fibrosis (r =  − 0.5); fibre size and muscle mass (r ≥ 0.4); and gait speed (r =  − 0.5). However, these associations were non-significant. In conclusion, we have demonstrated that it is feasible to characterise cellular senescence in human skeletal muscle and to explore associations with morphology and physical function in women and men of different ages. The findings require replication in larger studies.
Cradle-to-gate life cycle assessment of iodine production from caliche ore in Chile
Authors: Roche Lindsey , Muhl Marco , Finkbeiner Matthias 
Published: July 2023

Abstract
Purpose
Iodine and its compounds have several industrial uses, primarily in nutrition and healthcare. So far, no specific LCA data for industrial iodine production are available. The purpose of this study is to provide the first LCA using primary industry data for iodine production from caliche ore in Chile.

Methods
The study is a process-based, attributional LCA and follows the relevant ISO standards 14040/44. Primary data were collected from the world’s main producer representing their production for the years 2019 and 2020. Economic allocation was applied to deal with the by-product sodium nitrate. The impact assessment was performed with a set of CML 2001 indicators.

Results and discussion
Cradle-to-gate total LCIA results per 1000 kg of iodine prill product include a GWP100 of 1.48E+04 kg CO2 eq., an AP of 2.53E+02 kg SO2 eq., a POCP of 1.20E+01 kg C2H4 eq., an EP of 9.60E+00 kg PO43− eq., and an ADP fossil of 2.44E+05 MJ. The main contributor across process steps and for most impact categories is electricity consumption. Other hotspots include diesel combustion, hydrogen peroxide, sulfur, sulfuric acid, kerosene, and sodium hydroxide. A scenario analysis with renewable electricity revealed a reduction potential for all impact categories. As an example, the GWP could be reduced by 33–38%.

Conclusions
This study is the first LCA for iodine production from caliche ore based on primary industry data. The switch to renewable sources was identified as the main improvement potential for the hotspot electricity consumption, with a potential reduction of at least 25% for all impact categories except ODP.
COVID-19 and Climate Change: Re-thinking Human and Non-Human in Western Philosophy
Authors: Lloyd G. 
Published: July 2023

AbstractThe pre-conditions and the effects of the COVID-19 pandemic are inter-connected with those of climate change, prompting reflection on how to re-think the relations between human and non-human on a changing planet. This essay considers that issue with reference to the contrasts between the philosophies of Descartes and Spinoza, who offered radically different approaches to the conceptualization of human presence in Nature.