bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identity Formation and General and Cancer-specific Functioning in Adolescent and Emerging Adult Survivors of Childhood Cancer: A Longitudinal Study into Directionality of Effects
Authors: Vanderhaegen Janne , Prikken Sofie , Van Laere Elise , Lemiere Jurgen , Claes Laurence , Moons Philip , Uyttebroeck Anne , Jacobs Sandra , Luyckx Koen 
Published: April 2023

Abstract

Background
Adolescent and emerging adult survivors of childhood cancer generally adjust well psychologically similar to their peers. Nevertheless, some survivors are at greater risk for developing psychological and physical difficulties. To shed light on the psychosocial functioning of adolescent and emerging adult survivors of childhood cancer, personal identity formation and its interplay with general and cancer-specific functioning need to be investigated.

Purpose
To examine the longitudinal associations linking identity formation to general and cancer-specific functioning in adolescent and emerging adult childhood cancer survivors using three-wave data over a 2-year period.

Methods
Dutch-speaking survivors (at baseline: n = 125; 53% female; age range: 14–25 years) treated at the pediatric oncology department of the University Hospitals Leuven (Belgium), completed self-report questionnaires at three annual timepoints. Directionality of effects and correlated changes were examined using cross-lagged structural equation modeling.

Results
Regarding general functioning, bidirectional effects occurred. Life satisfaction positively predicted identity synthesis and both life satisfaction and good physical functioning negatively predicted identity confusion over time. Identity synthesis, in turn, positively predicted life satisfaction and identity confusion negatively predicted good physical functioning over time. Regarding cancer-specific functioning, mainly unidirectional effects occurred. Post-traumatic stress symptoms negatively predicted identity synthesis and positively predicted identity confusion over time, whereas the reverse pattern of associations was found for benefit finding. Several correlated changes were found linking identity formation and psychosocial functioning as well.

Conclusions
The present study uncovered clinically meaningful pathways linking identity formation to psychosocial functioning over time in adolescents and emerging adults who survived childhood cancer.
Effects of brood and group size on nestling provisioning and resource allocation in a communal bird
Authors: Savagian Amanda , Riehl Christina 
Published: April 2023

Abstract
Resource limitations, either due to environmental conditions or constraints on parental provisioning effort, can drive intense competition among offspring. In communal groups, resource availability may increase if parents receive assistance from other group members; however, if those caregivers also produce young, offspring demand may increase at the same time. It is possible, therefore, that the costs of intrabrood competition in large broods may outweigh the benefits of provisioning from additional caregivers. We tested the relationships between group size, brood size, and provisioning rates in the greater ani (Crotophaga major), a communally nesting cuckoo in which multiple breeding pairs and nonreproductive helpers cooperatively raise a shared brood. Crucially, brood and group size can vary independently in this species, allowing us to test changes in each variable separately. Using video footage of 2255 prey deliveries across 10 nests, we found that an increase in the number of adult caregivers within a group did not sufficiently offset a corresponding increase in the number of dependent young within a brood: prey availability per average nestling decreased with brood size, regardless of group size. In larger broods, last-hatched nestlings received significantly less prey than their broodmates, in part due to greater hatching asynchrony that exacerbated competitive asymmetries and facilitated inequality in food allocation. Our results indicate that last-hatched ani nestlings suffer a “double cost” in large broods: they must compete with more nestmates, and suffer disproportionately from asynchronous hatching. These costs may contribute to increased parent–offspring conflict and may constrain group size in communal breeders.
The anti-caste alter-network: equality labs and anti-caste activism in the US
Authors: Baishya Anirban Kapil , Mini Darshana Sreedhar , Soundararajan Thenmozhi 
Published: April 2023

Abstract
As a pan-South Asian phenomenon that marks certain groups and bodies as untouchable, caste-based discriminatory practices have also traveled with the South Asian diaspora. This article examines the case of anti-caste activism, especially in the context of its transnational potentials which have blossomed with the ubiquitous uptake of digital technology worldwide. We examine anti-caste activism in the US through the work of Equality Labs, an anti-caste civil rights organization that works with digital and non-digital activist strategies. Analyzing a range of material including surveys and reports, online chatter, and journalistic discourse we show how the organization’s work is part of a larger, transnational network of anti-caste activism—something we term the anti-caste alter-network.
Layer-specific stimulations of parvalbumin-positive cortical interneurons in mice entrain brain rhythms to different frequencies
Authors: David François , Borel Mélodie , Ayub Suleman , Ruther Patrick , Gentet Luc J 
Published: April 2023

Abstract
Neocortical interneurons provide inhibition responsible for organizing neuronal activity into brain oscillations that subserve cognitive functions such as memory, attention, or prediction. However, the interneuronal contribution to the entrainment of neocortical oscillations within and across different cortical layers was not described. Here, using layer-specific optogenetic stimulations with micro-Light-Emitting Diode arrays, directed toward parvalbumin-expressing (PV) interneurons in non-anesthetized awake mice, we found that supragranular layer stimulations of PV neurons were most efficient at entraining supragranular local field potential (LFP) oscillations at gamma frequencies (γ: 25–80 Hz), whereas infragranular layer stimulation of PV neurons better entrained the LFP at delta (δ: 2–5 Hz) and theta (θ: 6–10 Hz) frequencies. At the level of neuronal action potential activity, we observed that supragranular neurons better followed the imposed PV stimulation rhythm than their infragranular counterparts at most frequencies when the stimulation was delivered in their respective layer. Moreover, the neuronal entrainment evoked by local stimulation could propagate across layers, though with a lesser impact when the stimulation occurs in deep layers, suggesting a direction-specific laminar propagation. These results establish a layer-based framework for oscillations to entrain the primary somatosensory cortex in awake conditions.
Simultaneous Determination of Montelukast Sodium and Loratadine by Eco-Friendly Densitometry and Spectrophotometric Methods
Authors: Mahmoud Shimaa A , El-Kosasy Amira M , Fouad Fatma A 
Published: April 2023

Abstract
Recently, the aim of analytical community is to reduce the usage of hazardous chemicals; so eco-friendly, rapid, selective and cost-effective methods were developed for simultaneous determination of montelukast sodium (MKT) and loratadine (LRT). The first method was based on chromatographic separation performed on precoated silica gel 60 GF254 plates with ethyl acetate–ethanol 9: 1 (v/v) as the mobile phase. The developed plates were scanned and quantified at 260 nm. The method gives linear correlation over concentration ranges of 0.3–3.6 μg/spot and 0.2–4.0 μg/spot for MKT and LRT, respectively. It was also successfully applied to analysis of both drugs in their pharmaceutical preparation and human plasma. The other methods are UV-spectrophotometric methods based on smart spectra manipulating to zero order spectrum of each drug. These methods are named response correlation (RC), a-centering and ratio derivative methods. RC and a-centering methods were dependent on the presence of an isosbestic point between the overlapped spectra of both drugs. While ratio derivative method based on manipulation of the ratio spectra of both drugs. The two drugs obey Beer–Lambert law over the concentration ranges of 3.0–30.0 μg/mL in the three spectrophotometric methods. Moreover, the greenness of the developed methods is assessed using suitable analytical Eco-Scale and Green Analytical Procedure Index.
Ecofriendly Chromatographic Assay of Metformin Combinations; Content Uniformity Tests and Toxicity Profiling
Authors: Emam Aml A , Abdelaleem Eglal A , Magdy Fatma , Gouda Ahmed M , Abdallah Fatma F 
Published: April 2023

Abstract
Accurate, sensitive and green HPTLC chromatographic method was proposed for simultaneous determination of metformin, glipizide and sitagliptin in the presence of metformin potential toxic impurities melamine and cyanoguanidine. The separation was completed on silica gel HPTLC F254 plates using a mixture of ethyl acetate: methanol: ammonia: formic acid (7: 2: 0.2: 0.2, by volume) as a developing system with UV scanning for the developed bands at 235 nm. The Rf values for metformin, glipizide, sitagliptin, melamine and cyanoguanidine were 0.17, 0.84, 0.67, 0.47 and 0.75, respectively. Linear responses were observed in the ranges of 0.2–3, 0.07–1.5, 1.5–5, 0.8–4 and 0.4–2 μg/band with correlation coefficients of 0.9999, 0.9998, 0.9997, 0.9996 and 0.9998 for metformin, glipizide, sitagliptin, melamine and cyanoguanidine, respectively. The proposed method was validated as per ICH criteria with respect to linearity, accuracy, precision, specificity and robustness. The validated method was successfully applied for determination of the studied drugs in Janumet® and Engilor® tablets; also, the results were statistically compared to those obtained by the reported spectrophotometric method and no significant difference was found between them. This method permitted the accurate simultaneous determination of the studied drugs, indicating its ability to be used for routine quality control assays of these drugs.
Effects of ageing on aortic hemodynamics measured by 4D-flow MRI: a case series
Authors: Juffermans Joe F , Westenberg Jos J M , van den Boogaard Pieter J , Lamb Hildo J 
Published: April 2023

Abstract

Background
It has been demonstrated that the rate of aortic dilatation is influenced by alteration of aortic hemodynamics, such as normalized flow displacement (FDN) and wall shear stress (WSS). However, the effects of ageing on aortic hemodynamics have not yet been described.

Case summary
4D-Flow MRI derived aorta hemodynamics were derived in the ascending aorta of a patient with ascending aortic aneurysm (mean ± standard deviation: 46 ± 1 mm) and a healthy volunteer (aortic diameter 30 ± 1 mm) with long-term follow-up of ten and eight years, respectively. At all timepoints, compared to the healthy volunteer, the patient demonstrated higher magnitudes of FDN (7% ± 1% vs. 3% ± 1%) and WSS angle (36° ± 3° vs. 24° ± 6°), and lower WSS magnitude (565 ± 100 mPa vs. 910 ± 115 mPa), axial WSS (426 ± 71 mPa vs. 800 ± 108 mPa) and circumferential WSS (297 ± 64 mPa vs. 340 ± 85 mPa). The patient and healthy volunteer demonstrated different aortic dilatation rates (regression slope ± standard error: 0.2 ± 0.1 vs. 0.1 ± 0.2 mm per year) and trends in FDN (0.1% ± 0.1% vs. 0.1% ± 0.2% per year), WSS magnitude (22 ± 9 vs. 35 ± 13 mPa per year), axial WSS (19 ± 4 vs. 37 ± 7 mPa per year), circumferential WSS (9 ± 8 vs. 5 ± 15 mPa per year), and WSS angle (-0.5° ± 0.4° vs. -0.8° ± 1.0° per year).

Discussion
Aortic hemodynamic parameters are marginally affected by ageing and the aortic diameter in this case series. Since aortic hemodynamic parameters have been associated with aortic dilation by previous studies, the outcomes of the two subjects suggest that the aortic dilatation rate will remain constant while individuals are ageing and dilating.
Fulminant myocarditis in a young woman with mixed connective tissue disease: a case report
Authors: Hamana Tomoyo , Kawamori Hiroyuki , Satomi-Kobayashi Seimi , Yamamoto Yuzuru , Ikeda Yoshihiko , Hirata Ken-ichi 
Published: April 2023

Abstract

Background
Although cardiac involvement is relatively common in mixed connective tissue disease (MCTD), few reports on MCTD-associated fulminant myocarditis are available.

Case summary
A 22-year-old woman diagnosed with MCTD was admitted to our institution for cold-like symptoms and chest pain. Echocardiography revealed that the left ventricular ejection fraction (LVEF) had rapidly decreased from 50 to 20%. Because endomyocardial biopsy revealed no significant lymphocytic infiltration, immunosuppressant drugs were not started initially; however, steroid pulse therapy (methylprednisolone, one1000 mg/day) was initiated due to prolonged symptoms and unimproved haemodynamics. Despite strong immunosuppressant therapy, the LVEF did not improve, and severe mitral regurgitation appeared. Three days after steroid pulse therapy initiation, she experienced a sudden cardiac arrest; thus, venoarterial extracorporeal membrane oxygenation (VA-ECMO) and intra-aortic balloon pumping (IABP) were initiated. Subsequent immunosuppressant therapy was continued with prednisolone (100 mg/day) and intravenous cyclophosphamide (1000 mg). Six days after steroid therapy initiation, the LVEF improved to 40% and then recovered to near-normal levels. After successful weaning off of VA-ECMO and IABP, she was discharged. Thereafter, a detailed histopathological examination revealed multi-focal signs of ischaemic micro-circulatory injury and diffuse HLA-DR in the vascular endothelium, suggesting an autoimmune inflammatory response.

Discussion
We report a rare case of fulminant myocarditis in a patient with MCTD who recovered with immunosuppressive treatment. Despite the absence of significant lymphocytic infiltration findings on histopathological examination, patients with MCTD may experience a dramatic clinical course. Although it is unclear whether myocarditis is triggered by viral infections, certain autoimmune mechanisms may lead to its development.
A longitudinal study of facial asymmetry in a normal birth cohort up to 6 years of age and the predisposing factors
Authors: Launonen Anniina M , Vuollo Ville , Aarnivala Henri , Heikkinen Tuomo , Pirttiniemi Pertti , Valkama A Marita , Harila Virpi 
Published: April 2023

Summary

Objectives
This prospective, population-based cohort study aimed to investigate the development of facial asymmetry up to 6 years of age using a three-dimensional (3D) soft tissue imaging method in a normal population. In addition, the study sought to identify potential predisposing factors to facial asymmetry.

Methods
A total of 102 newborns were enrolled in the study at birth. 3D stereophotogrammetric images of the head and face were analysed at the ages of 12 months (T1), 3 years (T2), and 6 years (T3). The surface-based analysis involved the calculation of the average distance (mm) and the symmetry percentage (%) between the original and mirrored surfaces. For landmark-based analysis, the distance of facial landmarks to the facial midline was examined.

Results
The final analysis included 70 (68.6%) subjects. Surface-based analysis showed a significant improvement of facial symmetry from T1 to T3 in all facial areas. Landmark-based analysis showed that upper facial landmarks were located, on average, slightly on the left and lower facial landmarks slightly on the right in relation to the facial midline (P &lt; 0.001).

Limitations
The size of the study population was limited. Facial posture may affect the reliability of the results, especially in younger children.

Conclusion
Facial asymmetry is detectable in early childhood and tends to reduce with age in young children. The lower face deviates slightly to the right, and the upper face to the left in relation to the facial midline. Possible predisposing factors for facial asymmetry at the age of 6 years include deformational plagiocephaly, sleeping position, and previous facial asymmetry.
Prevention of white spot lesions with fluoride varnish during orthodontic treatment with fixed appliances: a systematic review
Authors: Sonesson Mikael , Twetman Svante 
Published: April 2023

Summary

Background
Fluoride varnish (FV) is an established technology for primary and secondary caries prevention.

Objective
The aim of this review was to evaluate the preventive effect of FV on development of white spot lesions (WSL) when regularly applied during orthodontic treatment with fixed appliances.

Search methods
We searched PubMed, Scopus and Google Scholar up to October 2022 using predetermined keywords.

Selection criteria
We included randomized controlled trials of a duration of minimum 12 months and at least quarterly FV applications.

Data collection and analysis
Based on abstracts, we retrieved full-text papers, extracted key outcome data, and assessed risk of bias. Primary outcome was prevalence of WSLs on subject level after debonding. We conducted a narrative synthesis and pooled comparable outcome data in a random effects model.

Results
We included seven studies covering 666 patients and assessed four publications with low or moderate risk of bias and three with high. The prevalence of WSLs at debonding varied between 12 and 55%. All studies presented results in favour for the FV intervention, one reached statistical significance on subject level. Five studies provided data for a meta-analysis. The pooled risk ratio was 0.64 [95% CI: 0.42, 0.98], indicating a statistically significant preventive effect. Certainty of evidence was graded as very low after reducing for risk of bias, inconsistency and imprecision.

Limitations
We pooled data on subject level and did not consider lesion severity on tooth level.

Conclusions and implications
Even if the certainty of evidence was very low, it was shown that FV can prevent development of WSL when regularly applied during orthodontic treatment. Larger investigations reporting a core outcome set are required to increase the certainty of evidence.

Registration
PROSPERO database (CRD42022370062).
Consumer preferences for beef quality grades on imported and domestic beef
Authors: Gao Shijun , Grebitus Carola , DeLong Karen 
Published: April 2023

Abstract
The Chinese government has recently introduced an updated beef quality-grade system. We implemented a shelf-simulation choice experiment and estimated random parameter logit models with error components to analyse Chinese consumer willingness to pay for domestic and imported beef flank labelled with the new quality grades and other relevant beef labels. Results indicated that Chinese consumers were willing to pay more for Premium quality domestic beef compared to ungraded beef, while Regular quality beef was discounted by consumers, particularly for imported beef. The results suggest that foreign beef producers could compete more closely with domestic beef if it was labelled as Premium quality.
Evaluation of the short-term outcomes of robotic-assisted radical resection for perihilar cholangiocarcinoma: a propensity-scored matching analysis
Authors: Huang Xi-Tai , Xie Jin-Zhao , Cai Jian-Peng , Chen Wei , Chen Liu-Hua , Liang Li-Jian , Yin Xiao-Yu 
Published: April 2023

AbstractBackgroundThe application of robotic-assisted radical resection in perihilar cholangiocarcinoma (pCCA) remains poorly defined. This study aimed to evaluate the safety and efficacy of robotic-assisted radical resection for pCCA in our institute.MethodsBetween July 2017 and July 2022, pCCA patients undergoing robotic-assisted and open radical resection at First Affiliated Hospital of Sun Yat-sen University (Guangzhou, China) were included. The short-term outcomes were compared by using propensity-scored matching (PSM) analysis.ResultsEighty-six pCCA patients were enrolled. After PSM at a ratio of 1:2, 10 and 20 patients were assigned to the robotic-assisted and open groups, respectively. There were no significant disparities in the clinicopathological features between the two groups. The robotic-assisted group had significantly longer operation time (median: 548 vs 353 min, P = 0.004) and larger total number of lymph nodes examined (median: 11 vs 5, P = 0.010) than the open group. The robotic-assisted group tended to have a lower intraoperative blood loss (median: 125 vs 350 mL, P = 0.067), blood transfusion rates (30.0% vs 70.0%, P = 0.056), and post-operative overall morbidities (30.0% vs 70.0%, P = 0.056) than the open group, even though the differences were not statistically significant. There were no significant differences in the negative resection margin, post-operative major morbidities, or post-operative length-of-stay between the robotic-assisted and open groups (all P &gt; 0.05).ConclusionsRobotic-assisted radical resection of pCCA may get a larger total number of lymph nodes examined than open surgery. Provided robotic-assisted surgery may be a feasible and safe technique for selected pCCA patients.
Ultrasound-guided fine-needle aspiration/biopsy-based pancreatic organoids establishment: an alternative model for basic and preclinical research
Authors: Chen Sheng , Wang Min , Liu Lei , Wang Guodong , Wang Lei , Zhong Changqing , Gao Chao , Wu Wei , Li Lianyong 
Published: April 2023

AbstractPancreatic ductal adenocarcinoma (PDAC), as one of the malignant cancers with the worst prognosis, is becoming the most urgent clinical problem. Due to the lack of early diagnosis and curable therapeutic methods, it is critical to exploit proper models that can capture the overall attributes of the primary tumor. Recently, organoid technology has emerged and flourished as a powerful tool to enable long-term culture of pancreatic tissues, including PDAC. As accumulating studies suggest, organoids can retain morphological, genetic, and behavioral traits, and have tremendous value in predicting the therapeutic response to conventional chemotherapy drugs or newfangled agents. Herein, this review comprehensively summarizes the tissue source including human fetal and adult pancreatic tissue to generate a pancreatic organoid as well as current organoids cultivate system. As PDAC organoids can be established from a small number of samples derived from endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/FNB), we also review the literature to date on EUS-FNA/FNB-based organoid constitution and its implementation in inquiring tumor behavior and evaluating therapeutic responses. By enabling the alignment of basic and clinical research platforms, the application of organoids would open up new avenues for drug discovery and maximally benefit translational medicine in the near future.