bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biphasic calcium phosphate doped with zirconia nanoparticles for reconstruction of induced mandibular defects in dogs: cone-beam computed tomographic and histopathologic evaluation
Authors: Taha Said K. , Hassan Elham A. , Mousa Sahar , El-Bassyouni Gehan T. , Shalash Heba N. , Abdel Hamid Mohamed A. 
Published: May 2023

AbstractThe present study aimed to evaluate osteogenic potential and biocompatibility of combining biphasic calcium phosphate with zirconia nanoparticles (4Zr TCP/HA) compared to biphasic calcium phosphate (TCP/HA) for reconstruction of induced mandibular defects in dog model. TCP/HA and 4Zr TCP/HA scaffolds were prepared. Morphological, physicochemical, antibacterial, cytocompatibility characterization were tested. In vivo application was performed in 12 dogs where three critical-sized mandibular defects were created in each dog. Bone defects were randomly allocated into: control, TCP/HA, and 4Zr TCP/HA groups. Bone density and bone area percentage were evaluated at 12 weeks using cone-beam computed tomographic, histopathologic, histomorphometric examination. Bone area density was statistically increased (p < 0.001) in TCP/HA and 4Zr TCP/HA groups compared to control group both in sagittal and coronal views. Comparing TCP/HA and 4Zr TCP/HA groups, the increase in bone area density was statistically significant in coronal view (p = 0.002) and sagittal view (p = 0.05). Histopathologic sections of TCP/HA group demonstrated incomplete filling of the defect with osteoid tissue. Doping with zirconia (4Zr TCP/HA group), resulted in statistically significant increase (p < 0.001) in bone formation (as indicated by bone area percentage) and maturation (as confirmed by Masson trichrome staining) compared to TCP/HA group. The newly formed bone was mature and organized with more trabecular thickness and less trabecular space in between. Physicochemical, morphological and bactericidal properties of combining zirconia and TCP/HA were improved. Combining zirconia and TCP/HA resulted in synergistic action with effective osteoinduction, osteoconduction and osteointegration suggesting its suitability to restore damaged bone in clinical practice.
Graphical Abstract
Reactivity of Health-Related Quality of Life to Perceived Stress: The Buffering Role of Psychosocial Resources in a Longitudinal Study of Adults with and Without HIV
Authors: Serrano Vanessa B. , Pasipanodya Elizabeth C. , Montoya Jessica L. , Heaton Robert K. , Jeste Dilip V. , Moore David J. 
Published: May 2023

AbstractPeople with HIV now have increased longevity; however, their health-related quality of life (HRQoL) still lags significantly compared to people without HIV. Perceived stress negatively impacts HRQoL, whereas psychosocial resources are linked to better HRQoL. This longitudinal analysis aims to explore the buffering role of psychosocial resources on the relationship between HRQoL and perceived stress. Participants (N = 240) included 142 persons with HIV (PwH) and 98 without HIV, M(SD) = 50.9(8.1) years. Multilevel models over four study years examined longitudinal relationships between HRQoL (outcome) and perceived stress (predictor) and potential moderation by psychosocial resources (personal mastery, social support, and resilience) by HIV serostatus. Among PwH only, personal mastery (p = 0.001), social support (p = 0.015), and resilience (p = 0.029) were associated with an attenuated effect of perceived stress (less negative slopes) for physical HRQoL over time. Bolstering personal mastery, social support, and resilience may have relevance for improving physical well-being among PwH.
A deep learning framework for early diagnosis of Alzheimer’s disease on MRI images
Authors: Arafa Doaa Ahmed , Moustafa Hossam El-Din , Ali Hesham A. , Ali-Eldin Amr M. T. , Saraya Sabry F. 
Published: May 2023

AbstractNumerous medical studies have shown that Alzheimer’s disease (AD) was present decades before the clinical diagnosis of dementia. As a result of the development of these studies with the discovery of many ideal biomarkers of symptoms of Alzheimer’s disease, it became clear that early diagnosis requires a high-performance computational tool to handle such large amounts of data, as early diagnosis of Alzheimer’s disease provides us with a healthy opportunity to benefit from treatment. The main objective of this paper is to establish a complete framework that is based on deep learning approaches and convolutional neural networks (CNN). Four stages of AD, such as (I) preprocessing and data preparation, (II) data augmentation, (III) cross-validation, and (IV) classification and feature extraction based on deep learning for medical image classification, are implemented. In these stages, two methods are implemented. The first method uses a simple CNN architecture. In the second method, the VGG16 model is the pre-trained model that is trained on the ImageNet dataset but applies the same model to the different datasets. We apply transfer learning, meaning, and fine-tuning to take advantage of the pre-trained models. Seven performance metrics are used to evaluate and compare the two methods. Compared to the most recent effort, the proposed method is proficient of analyzing AD, moreover, entails less labeled training samples and minimal domain prior knowledge. A significant performance gain on classification of all diagnosis groups was achieved in our experiments. The experimental findings demonstrate that the suggested designs are appropriate for basic structures with minimal computational complexity, overfitting, memory consumption, and temporal regulation. Besides, they achieve a promising accuracy, 99.95% and 99.99% for the proposed CNN model in the classification of the AD stage. The VGG16 pre-trained model is fine-tuned and achieved an accuracy of 97.44% for AD stage classifications.
Venous thromboembolism recurrence among one-and-done direct oral anticoagulant users: a retrospective longitudinal study
Authors: Alberts Mark , Zhdanava Maryia , Pilon Dominic , Caron-Lapointe Gabrielle , Lefebvre Patrick , Bookhart Brahim , Kharat Akshay 
Published: May 2023

Abstract
Background
Direct oral anticoagulants (DOACs) are the American Society of Hematology guideline-recommended treatment for venous thromboembolism (VTE) in the United States (US).

Aim
To compare risk of VTE recurrence between patients who, following the first fill, discontinued (“one-and-done”) versus those who continued (“continuers”) DOACs.

Method
Open source US insurance claims data (04/1/2017 to 10/31/2020) were used to select adult patients with VTE initiated on DOACs (index date). Patients with only one DOAC claim during the 45-day landmark period (starting on the index date) were classified as one-and-done and the remaining as continuers. Inverse probability of treatment weighting was used to reweight baseline characteristics between cohorts. VTE recurrence based on the first post-index deep vein thrombosis or pulmonary embolism event was compared using weighted Kaplan–Meier and Cox proportional hazard models from landmark period end to clinical activity or data end.

Results
27% of patients initiating DOACs were classified as one-and-done. After weighting, 117,186 and 116,587 patients were included in the one-and-done and continuer cohorts, respectively (mean age 60 years; 53% female; mean follow-up 15 months). After 12 months of follow-up, the probability of VTE recurrence was 3.99% and 3.36% in the one-and-done and continuer cohorts; the risk of recurrence was 19% higher in the one-and-done cohort (hazard ratio [95% confidence interval] = 1.19 [1.13, 1.25]).

Conclusion
Substantial proportion of patients discontinued DOAC therapy after the first fill, which was associated with significantly higher risk of VTE recurrence. Early access to DOACs should be encouraged to reduce the risk of VTE recurrence.
Gender disparities in accounting academia: analysis from the lens of publications
Authors: Uribe-Bohorquez Maria-Victoria , Rivera-Ordóñez Juan-Camilo , García-Sánchez Isabel-María 
Published: May 2023

AbstractThere is a significant gender gap in accounting academia that places women at a disadvantage in terms of recruitment, hiring, promotion, tenure, status, high-level areas or positions (both research and administrative), burden distribution of work, and remuneration. Women are disproportionately represented in part-time or non-tenure tracks, such as lecturers, instructors, and assistant professors. They experience a slower rate of advancement and have lower pay and prestige. Given that various authors attribute this situation to the level of research and production of papers in top-tier scientific journals, this article aims to describe women's participation as authors in cost and management accounting to contribute to clarifying possible causes of gender disparity in the accounting case.
The “Other” in Court: Islam and Muslims in Polish Judicial Opinions Published Online
Authors: Górska Ewa , Juzaszek Anna 
Published: May 2023

AbstractMuslims are a marginal minority in Poland, but research shows that they are often subject to negative perceptions and hostility from the majority. Orientalist stereotypes about Islam and the people associated with it are widespread and often reproduced in the media. Research from North America and the European Court of Human Rights suggests that such prejudices can affect the adjudication of cases involving Muslims. It may be presumed that Poland is no exception to that, and this assumption was the starting point for our empirical study. To date, there have been no studies on the perception of Muslims and Islam in the Polish legal system. This article presents the results of a qualitative thematic analysis of 57 judicial opinions issued by the common courts in Poland and published online, in which Islam or being Muslim was mentioned. The cases were categorised and texts of the judicial opinions closely analysed (with computer-assisted qualitative data analysis software) to identify recurring themes. The findings of this first exploratory study show that stereotypical representations and the “‘Othering” of Muslims do indeed occur in Polish courts, with some judges repeating Orientalist tropes that have become normalised in Polish society.
Immunostimulant potential of Moringa Oleifera leaves alcoholic extract versus Oregano Essential Oil (OEO) against cyclophosphamide-induced immunosuppression in broilers chicks
Authors: Mohamed Mostafa Abdelgaber , El-Mleeh Amany Abdelbaky , Hamad Rania Talat , Abu-Alya Ibrahim Said , El-Hewaity Mohamed Hamdy , Elbestawy Ahmed Ragab , Elbagory Abdelrahman Mahmoud , Sayed-Ahmed Ahmed Saber , Abd Eldaim Mabrouk Attia , Elshabrawy Omnia Ibrahim 
Published: May 2023

AbstractThe current study was conducted to evaluate the immunoenhancement effect ofMoringa oleiferaleaves alcoholic extract (MOLE) versus Oregano essential oil (OEO) against cyclophosphamide induced immunosuppression in broilers chicks. A total of a three hundred one-day-old chicks were assigned randomly into three main dietary groups, control, MOLE, and OEO for 14 days. After 14 days the three main experimental groups were subdivided into six groups, control, cyclophosphamide, MOLE, MOLE and Cyclophosphamide, OEO, and OEO and cyclophosphamide. Each group of these six groups was subdivided into three subgroups. Supplementation of broiler chicks with MOLE and OEO for 14 days significantly increased body weight compared to the control group. However, injection of broiler chicks with cyclophosphamide significantly induced body weight loss, impaired immunological response represented by decreasing total leukocytic count, differential leukocytic count, phagocytic activity, phagocytic index, and hemagglutinin inhibition titer for New Castle disease virus, lymphoid organs depletion, and increased the mortality rate. In contrast, supplementation of cyclophosphamide treated chicks with MOLE and OEO significantly reduced cyclophosphamide induced body weight loss and impaired immunological responses, as it showed significant increase in body weight, total leukocytic count, differential leukocytic count, phagocytic activity, phagocytic index, and hemagglutinin inhibition titer for New Castle disease virus, lymphoid organs proliferation, and reduced the mortality rate. This study indicated that MOLE and OEO supplementation ameliorated cyclophosphamide induced body weight loss and impaired immunological responses.
C-reactive protein and procalcitonin during course of sepsis and septic shock
Authors: Schupp Tobias , Weidner Kathrin , Rusnak Jonas , Jawhar Schanas , Forner Jan , Dulatahu Floriana , Dudda Jonas , Brück Lea Marie , Hoffmann Ursula , Bertsch Thomas , Akin Ibrahim , Behnes Michael 
Published: May 2023

Abstract
Objective
The study investigates the diagnostic and prognostic value of C-reactive protein (CRP) and procalcitonin (PCT) in patients with sepsis and septic shock.

Background
Limited data regarding the prognostic value of CRP and PCT during the course of sepsis or septic shock is available.

Methods
Consecutive patients with sepsis and septic shock from 2019 to 2021 were included monocentrically. Blood samples were retrieved from the day of disease onset (day 1), day 2, 3, 5, 7, and 10. Firstly, the diagnostic value of CRP and PCT for the diagnosis of a septic shock, as well as for the discrimination of positive blood cultures, was tested. Secondly, the prognostic value of the CRP and PCT was tested for 30-day all-cause mortality. Statistical analyses included univariable t-tests, Spearman’s correlations, C-statistics, and Kaplan–Meier analyses.

Results
A total of 349 patients were included, of which 56% had a sepsis and 44% a septic shock on day 1. The overall rate of all-cause mortality at 30 days was 52%. With an area under the curve (AUC) of 0.861 on day 7 and 0.833 on day 10, the PCT revealed a superior AUC than the CRP (AUC 0.440–0.652) with regard to the discrimination between patients with sepsis and septic shock. In contrast, the prognostic AUCs for 30-day all-cause mortality were poor. Both higher CRP (HR = 0.999; 95% CI 0.998–1.001; p = 0.203) and PCT levels (HR = 0.998; 95% CI 0.993–1.003; p = 0.500) were not associated with the risk of 30-day all-cause mortality. During the first 10 days of ICU treatment, both CRP and PCT declined irrespective of clinical improvement or impairment.

Conclusion
PCT was a reliable diagnostic tool for the diagnosis of septic shock compared to CRP. Both CRP and PCT were shown to have poor predictive value with regard to 30-day all-cause mortality and were not associated with the risk of all-cause mortality in patients admitted with sepsis or septic shock.
A Hebbian Model to Account for Musical Expertise Differences in a Working Memory Task
Authors: Lörch Lucas , Lemaire Benoît , Portrat Sophie 
Published: May 2023

AbstractThe TBRS*C computational model provides a mathematical implementation of the cognitive processes involved in complex span tasks. The logic of the core processes, i.e., encoding, refreshing/time-based decay, and chunking, is based on Hebbian learning, synaptic facilitation, and long-term neural plasticity, respectively. The modeling, however, takes place on a cognitive rather than a physiological level. Chunking is implemented as a process of searching for sequences of memoranda in long-term memory and recoding them as a single unit which increases the efficacy of memory maintenance. Using TBRS*C simulations, the present study investigated how chunking and central working memory processes change with expertise. Hobby musicians and music students completed a complex span task in which sequences of twelve note symbols were presented for serial recall of pitch. After the presentation of each memorandum, participants performed an unknown, notated melody on an electric piano. To manipulate the potential for chunking, we varied whether sequences of memoranda formed meaningful tonal structures (major triads) or arbitrary trichords. Hobby musicians and music students were each split up in a higher-expertise and a lower-expertise group and TBRS*C simulations were performed for each group individually. In the simulations, higher-expertise hobby musicians encoded memoranda more rapidly, invested less time in chunk search, and recognized chunks with a higher chance than lower-expertise hobby musicians. Parameter estimates for music students showed only marginal expertise differences. We conclude that expertise in the TBRS model can be conceptualized by a rapid access to long-term memory and by chunking, which leads to an increase in the opportunity and efficacy of refreshing.
Differential remodeling of subcutaneous white and interscapular brown adipose tissue by long-term exercise training in aged obese female mice
Authors: Félix-Soriano Elisa , Sáinz Neira , Gil-Iturbe Eva , Castilla-Madrigal Rosa , Celay Jon , Fernández-Galilea Marta , Pejenaute Álvaro , Lostao M. Pilar , Martínez-Climent José A. , Moreno-Aliaga María J. 
Published: May 2023

Abstract
Obesity exacerbates aging-induced adipose tissue dysfunction. This study aimed to investigate the effects of long-term exercise on inguinal white adipose tissue (iWAT) and interscapular brown adipose tissue (iBAT) of aged obese mice. Two-month-old female mice received a high-fat diet for 4 months. Then, six-month-old diet-induced obese animals were allocated to sedentarism (DIO) or to a long-term treadmill training (DIOEX) up to 18 months of age. In exercised mice, iWAT depot revealed more adaptability, with an increase in the expression of fatty acid oxidation genes (Cpt1a, Acox1), and an amelioration of the inflammatory status, with a favorable modulation of pro/antiinflammatory genes and lower macrophage infiltration. Additionally, iWAT of trained animals showed an increment in the expression of mitochondrial biogenesis (Pgc1a, Tfam, Nrf1), thermogenesis (Ucp1), and beige adipocytes genes (Cd137, Tbx1). In contrast, iBAT of aged obese mice was less responsive to exercise. Indeed, although an increase in functional brown adipocytes genes and proteins (Pgc1a, Prdm16 and UCP1) was observed, few changes were found on inflammation-related and fatty acid metabolism genes. The remodeling of iWAT and iBAT depots occurred along with an improvement in the HOMA index for insulin resistance and in glucose tolerance. In conclusion, long-term exercise effectively prevented the loss of iWAT and iBAT thermogenic properties during aging and obesity. In iWAT, the long-term exercise program also reduced the inflammatory status and stimulated a fat-oxidative gene profile. These exercise-induced adipose tissue adaptations could contribute to the beneficial effects on glucose homeostasis in aged obese mice.
Machine learning as an adjunct to expert observation in classification of radiographic knee osteoarthritis: findings from the Hertfordshire Cohort Study
Authors: Westbury Leo D. , Fuggle Nicholas R. , Pereira Diogo , Oka Hiroyuki , Yoshimura Noriko , Oe Noriyuki , Mahmoodi Sasan , Niranjan Mahesan , Dennison Elaine M. , Cooper Cyrus 
Published: May 2023

Abstract
Background
Osteoarthritis is the most prevalent type of arthritis. Many approaches exist for characterising radiographic knee OA, including machine learning (ML).

Aims
To examine Kellgren and Lawrence (K&L) scores from ML and expert observation, minimum joint space and osteophyte in relation to pain and function.

Methods
Participants from the Hertfordshire Cohort Study, comprising individuals born in Hertfordshire from 1931 to 1939, were analysed. Radiographs were assessed by clinicians and ML (convolutional neural networks) for K&L scoring. Medial minimum joint space and osteophyte area were ascertained using the knee OA computer-aided diagnosis (KOACAD) program. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was administered. Receiver operating characteristic analysis was implemented for minimum joint space, osteophyte, and observer- and ML-derived K&L scores in relation to pain (WOMAC pain score > 0) and impaired function (WOMAC function score > 0).

Results
359 participants (aged 71–80) were analysed. Among both sexes, discriminative capacity regarding pain and function was fairly high for observer-derived K&L scores [area under curve (AUC): 0.65 (95% CI 0.57, 0.72) to 0.70 (0.63, 0.77)]; results were similar among women for ML-derived K&L scores. Discriminative capacity was moderate among men for minimum joint space in relation to pain [0.60 (0.51, 0.67)] and function [0.62 (0.54, 0.69)]. AUC < 0.60 for other sex-specific associations.

Discussion
Observer-derived K&L scores had higher discriminative capacity regarding pain and function compared to minimum joint space and osteophyte. Among women, discriminative capacity was similar for observer- and ML-derived K&L scores.

Conclusion
ML as an adjunct to expert observation for K&L scoring may be beneficial due to the efficiency and objectivity of ML.
Horizon Scanning in Tissue Engineering Using Citation Network Analysis
Authors: Otsuka Kouhei , Takata Takuya , Sasaki Hajime , Shikano Mayumi 
Published: May 2023

Abstract
Background
Establishing a horizon scanning method is critical for identifying technologies that require new guidelines or regulations. We studied the application of bibliographic citation network analysis to horizon scanning.

Objective
The possibility of applying the proposed method to interdisciplinary fields was investigated with the emphasis on tissue engineering and its example, three-dimensional bio-printing.

Methodology and Results
In all, 233,968 articles on tissue engineering, regenerative medicine, biofabrication, and additive manufacturing published between January 1, 1900 and November 3, 2021 were obtained from the Web of Science Core Collection. The citation network of the articles was analyzed for confirmation that the evolution of 3D bio-printing is reflected by tracking the key articles in the field. However, the results revealed that the major articles on the clinical application of 3D bio-printed products are located in clusters other than that of 3D bio-printers. We investigated the research trends in this field by analyzing the articles published between 2019 and 2021 and detected various basic technologies constituting tissue engineering, including microfluidics and scaffolds such as electrospinning and conductive polymers. The results suggested that the research trend of technologies required for product development and future clinical applications of the product are sometimes detected independently by bibliographic citation network analysis, particularly for interdisciplinary fields.

Conclusion
This method can be applied to the horizon scanning of an interdisciplinary field. However, identifying basic technologies of the targeted field and following the progress of research and the integration process of each component of technology are critical.
Prediction of departure flight delays through the use of predictive tools based on machine learning/deep learning algorithms
Authors: Muros Anguita J.G. , Díaz Olariaga O. 
Published: May 2023

AbstractThe objective of this research is to predict the delays in the departure of scheduled commercial flights through a methodology that uses predictive tools based on machine learning/deep learning (ML/DL), with supervised training in regression, based on the available flight datasets. Since the novel contribution of this work is, first, to make the comparison of the predictions in terms of means and statistical variance of the different ML/DL models implemented and, second, to determine the coefficients of the importance of the features or flight attributes, using ML methods known as permutation importance, it is possible to rank the importance of flight attributes by their influence in determining the delay time and reduce the problem of selecting the most important flight attributes. From the results obtained, it is worth mentioning that the model that presents the best performance is the ensemble or combinatorial method of random forest regressor models, with an acceptable prediction range (measured with the root-mean-square-error).