bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination of coronary CT angiography, FFRCT, and risk factors in the prediction of major adverse cardiovascular events in patients suspected CAD
Authors: Wada Shinichi , Iwanaga Yoshitaka , Nakai Michikazu , Nakao Yoko M. , Miyamoto Yoshihiro , Noguchi Teruo ,   for The NADESICO Study Investigators
Published: March 2023

AbstractBackgroundTo examine the utility of fractional flow reserve by coronary computed tomography (CT) angiography (FFRCT) for predicting major adverse cardiovascular events (MACE) in patients with suspected coronary artery disease (CAD).MethodsThis was a nationwide multicenter prospective cohort study including consecutive 1187 patients aged 50−74 years with suspected CAD and had available coronary CT angiography (CCTA). In patients with ≥50% coronary artery stenosis (CAS), FFRCT was further analyzed. The Cox proportional hazards model was used to examine the association of FFRCT and cardiovascular risk factors with incident MACE within 2 years.ResultsAmong 933 patients with available information on MACE within 2 years after enrollment, the incidence rate of MACE was higher in 281 patients with CAS than in those without CAS (6.11 vs. 1.16 per 100 patient‐year). In 241 patients with CAS, the Cox proportional hazards analysis showed that FFRCT as well as diabetes mellitus and low high‐density lipoprotein cholesterol level were independently associated with incident MACE. Moreover, the hazard ratio was significantly higher in patients harboring all three factors compared to those harboring 0−2 of the three factors (6.01; 95% confidence interval: 2.77−13.03).ConclusionsCombinatorial assessment using CCTA for stenosis, FFRCT, and risk factors was useful for more accurate prediction of MACE in patients with suspected CAD. Among patients with CAS, those with lower FFRCT, diabetes mellitus, and low high‐density lipoprotein cholesterol level were at highest risk for MACE during the 2‐year period following enrollment.
First‐in‐Human, Single‐ and Multiple‐Ascending‐Dose, Food‐Effect, and Absolute Bioavailability Trials to Assess the Pharmacokinetics, Safety, and Tolerability of Pritelivir, a Nonnucleoside Helicase‐Primase Inhibitor Against Herpes Simplex Virus in Healthy Subjects
Authors: Kropeit Dirk , Bonsmann Susanne , von Richter Oliver , McCormick David , Pausch Jörg , Sumner Melanie , Birkmann Alexander , Zimmermann Holger , Rübsamen‐Schaeff Helga 
Published: March 2023

AbstractThe pharmacokinetics and safety of the novel herpes simplex virus helicase‐primase inhibitor pritelivir were evaluated in 5 phase 1 trials: a single‐ascending‐dose trial, 2 multiple‐ascending‐dose trials, a food‐effect trial, and an absolute bioavailability trial in healthy male subjects. One cohort of healthy female subjects was included in the single‐ascending‐dose trial. Pritelivir pharmacokinetics were linear up to 480 mg following single and up to 400 mg following multiple once‐daily doses. The half‐life ranged from 52 to 83 hours, and steady state was reached between 8 and 13 days. Maximum plasma concentration and area under the plasma concentration–time curve from time 0 to the last quantifiable concentration were 1.5‐ and 1.1‐fold higher in female compared to male subjects. Absolute bioavailability was 72% under fasted conditions. Following a fatty diet, pritelivir time to maximum concentration was 1.5 hour delayed and maximum plasma concentration and area under the plasma concentration–time curve from time 0 to the last quantifiable concentration were 33% and 16% higher, respectively. Pritelivir was safe and well tolerated up to 600 mg following single and up to 200 mg following multiple once‐daily doses. Considering a therapeutic dose of 100 mg once‐daily, pritelivir demonstrated a favorable safety and tolerability and pharmacokinetic profile in healthy subjects to support further development.
A three‐level three port isolated converter with reduced current stress for DC microgrid applications
Authors: S. Sofiya , Sathyan Shelas 
Published: March 2023

SummaryThis paper proposes a three‐level three port isolated converter (3L3PIC), which can be employed as an intermediate power conversion circuit for connecting different DC bus voltages in a DC microgrid. This topology utilize half bridge multilevel structure to reduce voltage stress across the transformer windings and the semiconductor switches. Conventionally the power transfer between the ports of a 3PIC were attained by traditional phase‐shift modulation (TPM), but this will impose increased current stress and associated losses in the converter at wide change in voltage conversion ratio. To minimize these losses, this paper introduces a 3L3PIC, that is, by employing dual phase‐shift modulation (DPM) in 3PIC. Steady state analysis of 3L3PIC are presented and derived the power transfer equations between the ports. The current equations through each port are determined at different combinations of voltage conversion ratios. Procedure for obtaining optimized phase‐shift values for both TPM and DPM techniques in 3PIC are explained. A comparison between the modulation schemes in 3PIC is performed and found better results for the DPM technique in terms of reduced current stress, reduced circulating power flow, and extended soft switching region. This in turn leads to a reduction in conduction losses and transformer losses in the converter. A hardware prototype of 1.5 kW 3PIC has been implemented and tested. The experimental results obtained validates with the theoretical analysis.
A review of the literature: How does prenatal opioid exposure impact placental health and fetal brain development?
Authors: Humphries Audrey , Simcox Kim , Howell Brittany 
Published: March 2023

AbstractIn recent years, there has been a sixfold increase in the number of pregnant people with opioid use disorder (OUD). Rates of neonatal opioid withdrawal syndrome (NOWS), previously known as neonatal abstinence syndrome (NAS), have significantly increased in virtually every state and demographic group (Healthcare Cost Utilization Project, HCUP, 2010). NOWS is a condition resulting from chronic exposure to either therapeutic opioid use (e.g., medication for OUD, chronic pain conditions) or nonprescribed opioid use. To date, there is no known prenatal treatment to help decrease the risk of infants developing NOWS and subsequent neurodevelopmental outcomes. Given the increasing support for how placental signaling, or placental programming, may play a role in downstream pathology, prospective research investigating how the placenta is affected by chronic opioid exposure morphologically, histologically, and at the cellular level may open up potential treatment opportunities in this field. In this review, we discuss literature exploring the physiological roles of nitric oxide and dopamine not only in the vascular development of the placenta, but also in fetal cerebral blood flow, neurogenesis, neuronal differentiation, and neuronal activity. We also discuss histological preclinical studies that suggest chronic opioid exposure to induce some combination of placental dysfunction and hypoxia in a manner similar to other well‐known placental pathologies, as denoted by the compensatory neovascularization and increased utilization of the placenta's supply of trophoblast cells, which play an essential role in placental angiogenesis. Overall, we found that the current literature, while limited, suggests chronic opioid exposure negatively impacts placental function and fetal brain development on a cellular and histopathological level. We conclude that it is worthwhile to consider the placenta as a therapeutic target with the ultimate goal of decreasing the incidence of NOWS and the long‐term impacts of prenatal opioid exposure.
Lithium Ion Transport Environment by Molecular Vibrations in Ion‐Conducting Glasses
Authors: Yamada Hiroki , Ohara Koji , Hiroi Satoshi , Sakuda Atsushi , Ikeda Kazutaka , Ohkubo Takahiro , Nakada Kengo , Tsukasaki Hirofumi , Nakajima Hiroshi , Temleitner Laszlo , Pusztai Laszlo , Ariga Shunsuke , Matsuo Aoto , Ding Jiong , Nakano Takumi , Kimura Takuya , Kobayashi Ryo , Usuki Takeshi , Tahara Shuta , Amezawa Koji , Tateyama Yoshitaka , Mori Shigeo , Hayashi Akitoshi 
Published: March 2023

Controlling Li ion transport in glasses at atomic and molecular levels is key to realizing all‐solid‐state batteries, a promising technology for electric vehicles. In this context, Li3PS4 glass, a promising solid electrolyte candidate, exhibits dynamic coupling between the Li+ cation mobility and the PS43− anion libration, which is commonly referred to as the paddlewheel effect. In addition, it exhibits a concerted cation diffusion effect (i.e., a cation–cation interaction), which is regarded as the essence of high Li ion transport. However, the correlation between the Li+ ions within the glass structure can only be vaguely determined, due to the limited experimental information that can be obtained. Here, this study reports that the Li ions present in glasses can be classified by evaluating their valence oscillations via Bader analysis to topologically analyze the chemical bonds. It is found that three types of Li ions are present in Li3PS4 glass, and that the more mobile Li ions (i.e., the Li3‐type ions) exhibit a characteristic correlation at relatively long distances of 4.0–5.0 Å. Furthermore, reverse Monte Carlo simulations combined with deep learning potentials that reproduce X‐ray, neutron, and electron diffraction pair distribution functions showed an increase in the number of Li3‐type ions for partially crystallized glass structures with improved Li ion transport properties. Our results show order within the disorder of the Li ion distribution in the glass by a topological analysis of their valences. Thus, considering the molecular vibrations in the glass during the evaluation of the Li ion valences is expected to lead to the development of new solid electrolytes.
Bimetallic Carbonyl Complexes Based on Iridium and Rhodium: Useful Tools for Hydrodefluorination Reactions
Authors: Kretschmar Konrad , Pelmenschikov Vladimir , Kaupp Martin , Braun Thomas , Wittwer Philipp , Rachor Simon , Cardozo Jesvita 
Published: March 2023

AbstractA set of bimetallic complexes based on iridium and rhodium with bis(diphenylphosphino)methane, bis(di‐iso‐propylphosphino)methane, diphenyl‐2‐pyridylphosphine and 2‐(di‐iso‐propylphosphino)imidazole bridging ligands was prepared. The complexes were characterized by NMR and IR spectroscopy and studied quantum‐chemically using DFT methods. The bimetallic systems succeeded in catalytic hydrodefluorination reactions of lower fluorinated aryl fluorides using molecular hydrogen and sodiumtert‐butoxide as a base. Effects of (i) ligand variation, (ii) mono‐ vs bimetallic nuclearity, and (iii) Ir vs Rh metal identity were studied and rationalized en route to achieve an effective hydrodefluorination.
Nonlinear signal‐based control for shake table experiments with sliding masses
Authors: Enokida Ryuta , Ikago Kohju , Guo Jia , Kajiwara Koichi 
Published: March 2023

AbstractThis study introduces the first application of nonlinear signal‐based control (NSBC) to shake table experiments with sliding masses. NSBC utilising a nonlinear signal was specifically developed for nonlinear system control. In shake table experiments with a steel structure, it realised a seismic acceleration record on the table with near 100% accuracy even when the structure displayed nonlinear characteristics due to yielding of its components. Regarding the severity, sliding is stronger than yielding because of the rapid shifts of stick and slip states. Sliding is utilised for structural damage mitigation in seismic isolation systems, which are prominent devices in earthquake engineering. However, when sliding occurs on a shake table, it significantly jeopardises the table control. Thus, this study investigates the performance of NSBC to shake table experiments involving the phenomenon. First, this study examines the effectiveness of NSBC via numerical simulations on a shake table with a sliding interface, demonstrated by the Karnopp model, with a friction coefficient of 0.2. Subsequently, a linear model is designed based on the stability analysis of NSBC to assess stability margins obtained from different models. Experiments are performed by placing masses weighing approximately twice the table weight on sliding interfaces with friction coefficients of 0.2–0.4. In these experiments, NSBC with a reasonable linear model design realised expected acceleration records with sufficiently high accuracies, whereas inversion‐based control failed. This study verifies the effectiveness of NSBC for shake table experiments with sliding masses.
Building a Conceptual Model for the Environmental Fate of the Fungicide Benzovindiflupyr
Authors: Hand Laurence H. , Marshall Samantha J. , Kuet Sui F. 
Published: March 2023

Abstract
Degradation of the fungicide benzovindiflupyr was slow in standard regulatory laboratory studies in soil and aquatic systems, suggesting it is a persistent molecule. However, the conditions in these studies differed significantly from actual environmental conditions, particularly the exclusion of light, which prevents potential contributions from the phototrophic microorganisms that are ubiquitous in both aquatic and terrestrial environments. Higher tier laboratory studies that include a more comprehensive range of degradation processes can more accurately describe environmental fate under field conditions. Indirect aqueous photolysis studies with benzovindiflupyr showed that the photolytic half-life in natural surface water can be as short as 10 days, compared with 94 days in pure buffered water. Inclusion of a light–dark cycle in higher tier aquatic metabolism studies, to include the contribution of phototrophic organisms, reduced the total system half-life from &gt;1 year in dark test systems to as little as 23 days. The relevance of these additional processes was confirmed in an outdoor aquatic microcosm study in which the half-life of benzovindiflupyr was 13–58 days. In laboratory soil degradation studies, the degradation rate of benzovindiflupyr was significantly faster in cores with an undisturbed surface microbiotic crust, incubated in a light–dark cycle (half-life of 35 days), than in regulatory studies with sieved soil in the dark (half-life &gt;1 year). A radiolabeled field study validated these observations, showing residue decline with a half-life of approximately 25 days over the initial 4 weeks. Conceptual models of environmental fate based on standard regulatory studies may be incomplete, and additional higher tier laboratory studies can be valuable in elucidating degradation processes and improving the prediction of persistence under actual use conditions. Environ Toxicol Chem 2023;42:995–1009. © 2023 SETAC
Abstract
Building a conceptual model for the environmental fate of the fungicide benzovindiflupyr. DAT, days after treatment; DT50, time taken for 50% of the compound to dissipate; PAR, photosynthetically active radiation.
Application of stable inversion to flexible manipulators modeled by the absolute nodal coordinate formulation
Authors: Drücker Svenja , Seifried Robert 
Published: March 2023

AbstractCompared to conventional robots, flexible manipulators offer many advantages, such as faster end‐effector velocities and less energy consumption. However, their flexible structure can lead to undesired oscillations. Therefore, the applied control strategy should account for these elasticities. A feedforward controller based on an inverse model of the system is an efficient way to improve the performance. However, unstable internal dynamics arise for many common flexible robots and stable inversion must be applied. In this contribution, an approximation of the original stable inversion approach is proposed. The approximation simplifies the problem setup, since the internal dynamics do not need to be derived explicitly for the definition of the boundary conditions. From a practical point of view, this makes the method applicable to more complex systems with many unactuated degrees of freedom. Flexible manipulators modeled by the absolute nodal coordinate formulation (ANCF) are considered as an application example.
Sustainable and scalable continuous synthesis of metal‐organic frameworks for CO2 capture
Authors: Chen Yipei , Wu Tao 
Published: March 2023

AbstractThis study demonstrates a continuous method for the production of high‐quality ZIF‐8 and HKUST‐1 (surface areas over 1500 m2/g) under mild synthesis conditions (ambient pressure and temperatures below 100°C) with only environmentally preferable green solvents (water and ethanol) being used in the entire synthesis process. High yields of metal organic frameworks (MOFs) are achieved (65% for ZIF‐8 and 79% for HKUST‐1). The comparison between the as‐synthesized samples and commercially available equivalents with respect to shape, size, surface area, thermal stability and CO2 uptake capability was conducted in this research. The synthesized MOFs both show competitive CO2 adsorption ability under a pressure in the range of 1–5 bar. Under a pressure of 5 bar,CO2 uptake capacity of ZIF‐8 and HKUST‐1 is 3.83 mmol/g and 6.68 mmol/g, respectively, which are 3.81 mmol/g and 6.62 mmol/g, respectively, for commercialized samples. The synthesized HKUST‐1 has higher values compared to the commercialized one within this range of pressures. This indicates the method developed in this study is promising to to be used for the continuous production of high‐quality MOFs for CO2 capture applications. © 2023 The Authors. Greenhouse Gases: Science and Technology published by Society of Chemical Industry and John Wiley & Sons Ltd.
A molecular guide to systemic therapy in salivary gland carcinoma
Authors: Weaver Alice N. , Lakritz Stephanie , Mandair Divneet , Ulanja Mark B. , Bowles Daniel W. 
Published: March 2023

AbstractSalivary gland carcinomas (SGC) are a rare and variable group of head and neck cancers with historically poor response to cytotoxic chemotherapy and immunotherapy in the recurrent, advanced, and metastatic settings. In the last decade, a number of targetable molecular alterations have been identified in SGCs including HER2 upregulation, androgen receptor overexpression, Notch receptor activation, NTRK gene fusions, and RET alterations which have dramatically improved treatment outcomes in this disease. Here, we review the landscape of precision therapy in SGC including current options for systemic management, ongoing clinical trials, and promising future directions.
Heat transfer and hydromagnetic electroosmotic Von Kármán swirling flow from a rotating porous disc to a permeable medium with viscous heating and Joule dissipation
Authors: Balaji R. , Prakash J. , Tripathi Dharmendra , Anwar Bég O. 
Published: March 2023

AbstractMagnetohydrodynamic flow and heat transfer in an ionic viscous fluid in a porous medium induced by a stretching spinning disc and modulated by electroosmosis under an axial magnetic field and radial electrical field is presented in this study. The effects of convective wall boundary conditions, Joule heating and viscous dissipation are incorporated. The governing partial differential conservation equations are transformed into a system of self‐similar coupled, nonlinear ordinary differential equations with associated boundary conditions. The Matlab bvp4c solver featuring a shooting technique and the fourth‐order Runge–Kutta–Fehlberg method are used to numerically solve the governing dimensionless boundary value problem. Multivariate analysis is also performed to examine the thermal characteristics. An increase in rotation parameter induces a reduction in the radial velocity, whereas it elevates the tangential velocity. Greater electrical field parameter strongly damps the radial velocity whereas it slightly decreases the tangential velocity. Increasing magnetic parameter also damps both the radial and tangential velocities. An increment in electroosmotic parameter substantially decelerates the radial flow but has a weak effect on the tangential velocity field. Increasing permeability parameter (inversely proportional to permeability) markedly damps both radial and tangential velocities. The pressure gradient is initially enhanced near the disk surface but reduced further from the disk surface with increasing magnetic parameter and electrical field parameter, whereas the opposite effect is produced with increasing Joule dissipation. Increasing magnetic and rotational parameters generate a strong heating effect and boost temperature and thermal boundary layer thickness. Nusselt number is boosted with increasing Brinkman number (viscous heating effect) and Reynolds number. The simulations are relevant to electromagnetic coating flows, bioreactors and electrochemical sensing technologies in medicine.
Random fractional partial differential equations and solutions for water movement in soils: Theory and applications
Authors: Su Ninghu 
Published: March 2023

AbstractThis paper analyses a set of random fractional partial differential equations (rfPDEs) for water movement in soils. The rfPDEs for both rigid and swelling soils are solved for both a random flux boundary condition (BC), and random concentration BC. Solutions from a random flux BC are presented for the large‐time and small‐time situations with the large‐time solution as a very simple method for determining the flux through the surface of the soil. The equation of cumulative infiltration is presented with random parameters of the rfPDE subject to a random concentration BC. The simulations using the results of the rfPDE for the two types of BCs yielded encouraging and stable results based on two sets of field data: the first set of the data was measurements at a single site while the second set was from 26 measurements in a small catchment. The results suggest that the presented procedures are very useful methods for the interpolation, extrapolation, and prediction of hydrological variables and parameters such as water content, hydraulic conductivity or the flux through the surface of the soil. The methodologies presented in this paper are able to reveal and reproduce the realistic hydrological processes in nature which are often stochastic and random.