bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on Potential and Practices of Rooftop Rainwater Harvesting System in Oxford College of Engineering and Management
Authors: KC Manila , Bhandari Min Prasad , Timilsena Sambriddhi , Lamichhane Sangina , Adhikari Basanta Prasad , Poudel Ashish , Kafle Sarad Chandra 
Published: April 2023

The objective of this study was to evaluate the possibility of promoting rooftop rainwater harvesting to address future water scarcity in the Oxford College of Engineering and Management Nawalparasi district. AutoCAD software drew accepted plans and maps; manual measurement was done with measuring tape since some parts were missing.
The results show that the linear forecast 1558.139, 1581.57mm,1548.63mm, 1598.14mm and 1570.64mm. The volume of water is 5135.54, 5028.16, 5188.94, 5099.68 respectively. It also shows the calculation of water demand which is 5,820,000 liters per year, and the water harvested is 5188946.58 liters per year. Finally, with this ratio, we realized we could fulfil 89.15% of water demand through water harvesting. The time series relevant results indicated that the A.R.I.M.A. model of forecasting rainfall was based on (0.1.0), signifying the R Square value is .631 and the p-value is insignificant (p > 250), which is better for this forecasting model.
Features of Life Meaning Orientations and Defensive-Coping Behaviour of Russian and Foreign Students
Authors: Perchenko E. L. , Gudina T. V. 
Published: April 2023

The relevance of the study is due to the need to comprehend the influence of cultural and value orientations on the behavior of Russian and foreign students in difficult situations. Relying on meaningful life guidelines helps to transform and improve one’s own line of response at difficult social crisis conditions and accumulate a baggage of culturally acceptable solutions. The need to understand this problem determined the purpose of the study – to identify features in the manifestation of meaningful life orientations and differences in the strategies of protective coping behavior among Russian and foreign students (from the Republic of Tajikistan). Based on the set goal, using empirical and interpretive research methods, results were obtained for a total sample of 100 people. The subjects were first-year students from Tajikistan and Russia. It was revealed that Russian students in crisis situations actively try to comprehend it and, nevertheless, satisfy their significant needs, while foreign young people, most often, smooth out, mitigate discomfort, their behavior is compensatory in nature. Nevertheless, differences in value-semantic orientations and, in accordance with this, building their own trajectory of protective and coping behavior allow students to adapt in society, coordinating their traditional values with the modern cultural transformation of society.
The Position of the University in the Infrastructure, Which Supports Technological Entrepreneurship
Authors: Zayakina R. A. 
Published: April 2023

The article’s goal is to eliminate the contradiction between the need for university activities to support and develop technological entrepreneurship and the lack of a sequence of steps leading to the achievement of the desired result. This contradiction is proposed to be resolved by identifying the position of the university in the infrastructure supporting technological entrepreneurship.The paper highlights three main infrastructural positions of the university, called “Supplier of Talents”, “Platform of Academic Technological Entrepreneurship” and “Technological Entrepreneurial Hub”. The first focuses on the development of creative thinking of students seeking to develop high-tech products and support their entrepreneurial intentions. The second focuses on the achievements of university researchers, based on which promising high-tech start-ups are launched and profitable small innovative enterprises are developed. The third relies on mediation and facilitation to coordinate communications between key parties for promoting high-tech business. In this position, the university is an access point to the main success factors of a technological entrepreneurial project. It is more than others capable of stimulating the economic development of the region.One university can hold several positions. Each of the listed positions is endowed with functional characteristics corresponding to their purpose and performs the tasks assigned to them. Starting from an infrastructural position close to the university, it becomes possible to clearly define the criteria that the university needs to have to effectively fulfill these tasks. And the presence of criteria makes it possible to identify dominant problems, adapt university resources, and bring social practices and educational technologies into line.
Remarks on “Perov Fixed-Point Results on F-contraction Mappings Equipped with Binary Relation”
Authors: Mitrovic Slobodanka , Fabiano Nicola , Radenović Stojan 
Published: April 2023

Since 1964, when I.A. Perov introduced the so-called generalized metric space where \(d(x,y)\) is an element of the vector space \(\mathbb{R}^m\). Since then, many researchers have considered various contractive conditions on this type of spaces. In this paper, we generalize, extend and unify some of those established results. It is primarily about examining the existence of a fixed point of some mapping from \(X\) to itself, but if \((x,y)\) belong to some relation \(R\) on the set \(X\). Then the binary relation \(R\) and some \(F\) contraction defined on the space cone \(\mathbb{R}^m\) are combined. We start our consideration on the paper [1] and give strict critical remarks on the results published in there. Also, we improve their result by weakening one condition.
Một thuật toán giấu tin trong ảnh có bảng màu
Authors: Ất Phạm Văn , Tuấn Đỗ Văn 
Published: April 2023

This paper proposes a new algorithm to embed data in palette image. In each image block oforiginal image, this algorithm can hide a bit by modifying at most one pixel of block. New color of modified pixel resembles the color of its some neighborhood pixels, so the image after hiding veryclose to the original image. The experimental results showed that the invisible of proposed algorithm is better than algorithms Fridrich and Ez Stego
Role of Balanced Scorecard in Evaluating Total Productive Maintenance Performance
Authors: Abidmuslim Hraiga Raad , Maher Muhammad Ali Fadel Ahmed , Abdulhassan Abbas Ali 
Published: April 2023

In light of the general inadequacy in the performance of the economic units operating in Iraq, and the contemporary developments in all the various sciences, Iraqi economic units have become obligated to use modern technologies applied around the world. Keeping abreast of these developments is done by moving away from traditional methods of evaluating performance and applying approved and accepted methods of evaluating performance. This will lead to an increase in the efficiency and effectiveness of the activities of economic units. In addition, this drives to reduce production costs. Accordingly, this study aims to clarify the application of the balanced scorecard technique and its role in evaluating the overall performance of the economic unit and the performance of total productive maintenance in particular. The study also aims to highlight the role of the balanced scorecard technique in evaluating the performance of total productive maintenance in order to develop the Iraqi industrial sector. The research selects the sulfuric acid factory in Al-Furat Company for Chemical Industries and Pesticides as a sample for the study. The most important finding is that the application of the balanced scorecard technique, based on the measures that have an impact on the overall productive maintenance, contributes to evaluating the total performance of the economic unit and evaluating total productive maintenance activities.
Paper type: Research paper.
Removal efficacy of fly ash composite filler on tailwater nitrogen and phosphorus and its application in constructed wetlands
Authors: Wang Shuhang , Yang Haoran , Che Feifei , Huang Wei , Yang Dianhai 
Published: April 2023

Constructed wetlands (CWs) have been widely used in tailwater treatment. However, it is difficult to achieve considerable removal efficiency of nitrogen and phosphorus in tailwater solely by CWs—an efficient green wetland filler is also important. This study investigated 160 domestic sewage treatment facilities (DSTFs) in rural areas from two urban areas in Jiaxing for TP and NH3-N and found that TP and NH3-N concentrations in rural domestic sewage (RDS) in this plain river network are still high. Therefore, we selected a new synthetic filler (FA-SFe) to enhance nitrogen and phosphorus reduction, and we discuss the importance of filler in constructed wetlands. Experiments revealed the adsorption capacity of the new filler: the maximum adsorption amounts of TP and NH3-N reached 0.47 g m-2 d-1 and 0.91 g m-2 d-1, respectively. The application potential of FA-SFe was verified in actual wastewater treatment, with the removal rates of ammonia nitrogen and TP reaching 71.3% and 62.7%, respectively. This study provides a promising pathway for nitrogen and phosphorus removal from rural tailwaters.
Simultaneous effect of different chromatographic conditions on the chromatographic retention of pentapeptide derivatives (HGRFG and NPNPT)
Authors: Peng Huan , Yang Xiangrong , Fang Huanle , Zhang Zhongqi , Zhao Jinli , Zhao Te , Liu Jianli , Li Yan 
Published: April 2023

Introduction: Oligopeptides exhibit great prospects for clinical application and its separation is of great importance in new drug development.Methods: To accurately predict the retention of pentapeptides with analogous structures in chromatography, the retention times of 57 pentapeptide derivatives in seven buffers at three temperatures and four mobile phase compositions were measured via reversed-phase high-performance liquid chromatography. The parameters (kHA, kA, and pKa) of the acid–base equilibrium were obtained by fitting the data corresponding to a sigmoidal function. We then studied the dependence of these parameters on the temperature (T), organic modifier composition (φ, methanol volume fraction), and polarity (PmN parameter). Finally, we proposed two six-parameter models with (1) pH and T and (2) pH and φ or PmN as the independent variables. These models were validated for their prediction capacities by linearly fitting the predicted retention factor k-value and the experimental k-value.Results: The results showed that logkHA and logkA exhibited linear relationships with 1/T, φ or PmN for all pentapeptides, especially for the acid pentapeptides. In the model of pH and T, the correlation coefficient (R2) of the acid pentapeptides was 0.8603, suggesting a certain prediction capability of chromatographic retention. Moreover, in the model of pH and φ or PmN, the R2 values of the acid and neutral pentapeptides were greater than 0.93, and the average root mean squared error was approximately 0.3, indicating that the k-values could be effectively predicted.Discussion: In summary, the two six-parameter models were appropriate to characterize the chromatographic retention of amphoteric compounds, especially the acid or neutral pentapeptides, and could predict the chromatographic retention of pentapeptide compounds.
Impaired sensitivity to thyroid hormones is associated with hyperuricemia in a Chinese euthyroid population
Authors: Lu Yingning , Wang Jie , An Yu , Liu Jia , Wang Ying , Wang Guang , Leng Song 
Published: April 2023

ObjectiveImpaired sensitivity to thyroid hormones has been reported as a common metabolic disorder, and it remains poorly understood whether it interplays with uric acid (UA) metabolism as an established risk factor for cardiovascular diseases (CVDs). We aimed to investigate the relationship between thyroid hormone sensitivity and elevated UA in a Chinese euthyroid population.MethodsA total of 15,955 euthyroid subjects were included in this study. Thyroid hormone sensitivity indices were calculated, including the thyroid feedback quantile-based index (TFQI), the Chinese-referenced parametric TFQI (PTFQI), the TSH index (TSHI), and the thyrotropin thyroxine resistance index (TT4RI), and the FT3/FT4 ratio. Linear and logistic regression analyses were performed to detect the association between thyroid hormone sensitivity and elevated UA.ResultsSubjects with reduced sensitivity to thyroid hormones had increased UA levels in both genders (p for trend &lt; 0.001). Logistic and linear regression analyses showed that higher TFQI, PTFQI, TSHI, and TT4RI were positively associated with elevated UA levels, but negatively associated with the FT3/FT4 ratio. The odds ratio (OR) of the highest versus the first quartile of TFQI was 1.20 (1.05, 1.38) in men and 1.80 (1.46, 2.23) in women (p &lt; 0.001). PTHQI, TSHI, and TT4RI obtained similar results in both genders. Conversely, the highest quartile of the FT3/FT4 ratio was negatively correlated with elevated UA levels [men: OR 0.78 (0.68,0.89), women: OR 0.66 (0.53,0.81)].ConclusionImpaired sensitivity to thyroid hormones was associated with elevated UA levels in euthyroid subjects. Our findings shed light on the role of thyroid hormone sensitivity in UA metabolism.
Growth differentiation factor-15/adiponectin ratio as a potential biomarker for metabolic syndrome in Han Chinese
Authors: Zheng Shuai , Shen Min , Qian Yu , Li Shushu , Chen Yang , Jiang Hemin , Lv Hui , Chen Doudou , Zhao Ruiling , Zheng Xuqin , Sun Min , Yang Tao , Shi Yun , Fu Qi 
Published: April 2023

AimsGrowth differentiation factor-15 (GDF-15) and adiponectin are adipokines that regulate metabolism. This study aimed to evaluate the roles of GDF-15, adiponectin, and GDF-15/adiponectin ratio (G/A ratio) as biomarkers for detecting metabolic syndrome (MS).Materials and methodsThis cross-sectional study included 676 participants aged 20–70 years in Jurong, China. The participants were divided into four groups based on sex and age (&lt;40 and ≥40 years). MS was defined according to the modified National Cholesterol Education Program Adult Treatment Panel III criteria. Receiver operating characteristic curves were used to evaluate the performance of GDF-15, adiponectin, and the G/A ratio in predicting MS.ResultsThe prevalence of MS was 22.0% (149/676). Logistic regression analysis indicated that the G/A ratio and adiponectin levels, but not GDF-15 levels, were correlated with MS [odds ratio; 95% CI 1.010 (1.006–1.013) and 0.798 (0.735–0.865), respectively] after adjusting for confounding factors. The G/A ratio displayed a significant relationship with MS in each subgroup and with each MS component in both men and women; however, adiponectin concentrations were significantly associated with MS and all its components only in men (all P &lt;0.05). The area under the curve (AUC) of the G/A ratio and the adiponectin level for MS was 0.758 and 0.748, respectively. The highest AUC was 0.757 for the adiponectin level in men and 0.724 for the G/A ratio in women.ConclusionsThis study suggests that the G/A ratio and adiponectin are potential biomarkers for detecting MS in women and men, respectively.
Longitudinal analysis of SARS-CoV-2 infection and vaccination in the LA-SPARTA cohort reveals increased risk of infection in vaccinated Hispanic participants
Authors: Jenkins Meagan M. , Phan Tran Donna , Flores Evelyn A. , Kupferwasser Deborah , Pickering Harry , Zheng Ying , Gjertson David W. , Ross Ted M. , Schaenman Joanna M. , Miller Loren G. , Yeaman Michael R. , Reed Elaine F. 
Published: April 2023

IntroductionSARS-CoV-2 is the etiologic agent of coronavirus disease 2019 (COVID-19). Questions remain regarding correlates of risk and immune protection against COVID-19.MethodsWe prospectively enrolled 200 participants with a high risk of SARS-CoV-2 occupational exposure at a U.S. medical center between December 2020 and April 2022. Participant exposure risks, vaccination/infection status, and symptoms were followed longitudinally at 3, 6, and 12 months, with blood and saliva collection. Serological response to the SARS-CoV-2 spike holoprotein (S), receptor binding domain (RBD) and nucleocapsid proteins (NP) were quantified by ELISA assay.ResultsBased on serology, 40 of 200 (20%) participants were infected. Healthcare and non-healthcare occupations had equivalent infection incidence. Only 79.5% of infected participants seroconverted for NP following infection, and 11.5% were unaware they had been infected. The antibody response to S was greater than to RBD. Hispanic ethnicity was associated with 2-fold greater incidence of infection despite vaccination in this cohort.DiscussionOverall, our findings demonstrate: 1) variability in the antibody response to SARS-CoV-2 infection despite similar exposure risk; 2) the concentration of binding antibody to the SARS-CoV-2 S or RBD proteins is not directly correlated with protection against infection in vaccinated individuals; and 3) determinants of infection risk include Hispanic ethnicity despite vaccination and similar occupational exposure.
Effect of renin-angiotensin-aldosterone system inhibitors on survival outcomes in cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis
Authors: Shen Jinhai , Hou Hui , Liang Bowen , Guo Xiao , Chen Li , Yang Yong , Wang Yun 
Published: April 2023

BackgroundEffect of renin-angiotensin-aldosterone system inhibitors (RAASIs) in combination with immune checkpoint inhibitors (ICIs) on prognoses in cancer patients remains controversial. This study systematically evaluated the effect of RAASIs on survival outcomes in cancer patients receiving ICIs treatment and provided an evidence-based reference for the rational use of RAASIs and ICIs combination therapy in clinical practice.MethodsStudies evaluating the prognosis of RAASIs-used versus RAASIs-free in cancer patients receiving ICIs treatment from inception to 1 November 2022 were retrieved by searching PubMed, Cochrane Library, Web of Science, Embase, and major conference proceedings. Studies in English reporting hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS) and/or progression-free survival (PFS) were included. Statistical analyses were conducted using the software Stata 17.0.ResultsA total of 12 studies containing 11739 patients were included, comprising ~4861 patients in the RAASIs-used and ICIs-treated group and ~6878 patients in RAASIs-free and ICIs-treated group. The pooled HR was 0.85 (95%CI, 0.75–0.96; P = 0.009) for OS and 0.91 (95%CI, 0.76–1.09; P = 0.296) for PFS, indicating a positive effect of RAASIs concomitant with ICIs on cancer patients. This effect was observed especially in patients with urothelial carcinoma (HR, 0.53; 95%CI, 0.31-0.89; P = 0.018) and renal cell carcinoma (HR, 0.56; 95%CI, 0.37-0.84; P = 0.005) on OS.ConclusionConcomitant use of RAASIs and ICIs enhanced the efficacy of ICIs and this combination regimen was associated with significantly improved OS and a trend towards better PFS. RAASIs can be considered as adjuvant drugs when hypertensive patients receive ICIs treatment. Our results provide an evidence-based reference for the rational use of the RAASIs and ICIs combination therapy to improve the efficacy of ICIs in clinical practice.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022372636; https://inplasy.com/, identifier INPLASY2022110136.
Assessing the role of lipid-lowering therapy on multi-cancer prevention: A mendelian randomization study
Authors: Min Yu , Wei Xiaoyuan , Liu Zheran , Wei Zhigong , Pei Yiyan , Li Ruidan , Jin Jing , Su Yongllin , Hu Xiaolin , Peng Xingchen 
Published: April 2023

Background: Statin use for cancer prevention has raised wide attention but the conclusions are still controversial. Whether statins use have exact causal effects on cancer prevention remains unclear.Methods: Based on the Genome-Wide Association Studies (GWAS) datasets from the large prospective UK Biobank and other consortium databases, two-sample mendelian randomization (MR) analysis was conducted to explore the causal effects of statins use on varied site-specific cancer risks. Five MR methods were applied to investigate the causality. The stability, heterogeneity, and pleiotropy of MR results were also evaluated.Results: The atorvastatin use could increase the risk of colorectal cancer (odd ratio (OR) = 1.041, p = 0.035 by fixed-effects inverse variance weighted (IVW) method (IVWFE), OR = 1.086, p = 0.005 by weighted median; OR = 1.101, p = 0.048 by weighted mode, respectively). According to the weighted median and weighted mode, atorvastatin could modestly decrease the risk of liver cell cancer (OR = 0.989, p = 0.049, and OR = 0.984, p = 0.004, respectively) and head and neck cancer (OR = 0.972, p = 0.020). Besides, rosuvastatin use could reduce the bile duct cancer risk by 5.2% via IVWEF method (OR = 0.948, p = 0.031). No significant causality was determined in simvastatin use and pan-cancers via the IVWFE or multiplicative random-effects IVW (IVWMRE) method if applicable (p &gt; 0.05). There was no horizontal pleiotropy observed in the MR analysis and the leave-one-out analysis proved the stability of the results.Conclusion: The causalities between statin use and cancer risk were only observed in colorectal cancer and bile duct cancer in the European ancestry population. Future works are warranted to provide more robust evidence for supporting statin repurposing for cancer prevention.
Virtual self-conversation using motivational interviewing techniques to promote healthy eating and physical activity: A usability study
Authors: Anastasiadou Dimitra , Herrero Pol , Vázquez-De Sebastián Julia , Garcia-Royo Paula , Spanlang Bernhard , Álvarez de la Campa Elena , Slater Mel , Ciudin Andreea , Comas Marta , Ramos-Quiroga J. Antoni , Lusilla-Palacios Pilar 
Published: April 2023

IntroductionWe aim to examine the usability of a Virtual Reality (VR) platform, called ConVRSelf, which has been designed to address the needs of People Living With Obesity (PLWO).MethodsFourteen participants with a desire to eat healthier and exercise more (6 normal weight and 8 PLWO; Mean age = 41.86, SD = 13.89) were assigned to the experimental group (EG) or the control group (CG). EG participants, after being trained on motivational interviewing skills, engaged in a virtual self-conversation using embodiment and body swapping techniques, which aimed to normalize and resolve their ambivalence to change lifestyle habits. CG participants, embodied in their virtual bodies, participated in a pre-established discourse with a virtual counselor giving them psychoeducational advice about how to change lifestyle habits. A mixed-methods design was used, involving a semi-structured interview and self-report questionnaires, including readiness to change habits (Readiness Rulers), body ownership (Body Ownership Questionnaire, BOQ), and system usability (System Evaluation Questionnaire, SEQ). Thematic content analysis was carried out for qualitative data while statistical data analysis was carried out using SPSS 20.0.ResultsParticipants from both groups showed high readiness to change lifestyle (Readiness Rulers) before engaging with the virtual experiences, which was maintained at the same level after the interventions and their scores on the SEQ and BOQ were satisfactory. Regarding qualitative information obtained from the interviews, almost all participants found the VR experience to be novel, interesting, and enjoyable. A higher acceptability was observed among PLWO from the EG than normal weight participants from the same group, a promising finding for the ConVRSelf platform, which had been specifically designed to address the needs of PLWO.ConclusionThe ConVRSelf system is well-accepted by participants and is ready to be tested with PLWO in a clinical setting.