bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pseudomonas lipopeptide: An excellent biomedical agent
Authors: Chauhan Vivek , Mazumdar Shreya , Pandey Akash , Kanwar Shamsher S. 
Published: January 2023

AbstractLipopeptides are surface active molecules with hydrophilic and hydrophobic regions and are kenned to be engendered by different species of Bacillus and Pseudomonas. These lipopeptides can be applied in different domains because of their remarkable properties like antibacterial, antifungal, anticorrosion, antitumor, and antiviral. They act by engendering pores in the cell membrane to perforate and conclusively disrupt them. This property of lipopeptide is valuable as an antimicrobial agent. In 2003, lipopeptides were approved as an antibiotic drug in the United States by the USA Food and Drug Administration (FDA) for the purpose of skin and blood infections caused by bacterial species. The biosynthetic genes for these lipopeptides are regulated by the nonribosomal peptide synthetase system. Amphisin, Tolaasin, Viscosin, and Syringomycin are the four main types of lipopeptides produced by Pseudomonas species. Since these lipopeptides are nontoxic, biodegradable, and environmentally cordial, they can abbreviate undesirable ecological perturbances. They can be considered a multifarious weapon for their application in different domains such as biocontrol agents in plants, emulsifiers in cosmetic and food industries, anticorrosion agents in petroleum industries, and antimicrobial agents in pharmaceutical and biomedical industries.
Regulatory utility of mechanistic modeling to support alternative bioequivalence approaches: A workshop overview
Authors: Babiskin Andrew , Wu Fang , Mousa Youssef , Tan Ming‐Liang , Tsakalozou Eleftheria , Walenga Ross L. , Yoon Miyoung , Raney Sam G. , Polli James E. , Schwendeman Anna , Krishnan Vishalakshi , Fang Lanyan , Zhao Liang 
Published: January 2023

AbstractOn September 30 and October 1, 2021, the US Food and Drug Administration (FDA) and the Center for Research on Complex Generics cosponsored a live virtual workshop titled “Regulatory Utility of Mechanistic Modeling to Support Alternative Bioequivalence Approaches.” The overall aims of the workshop included (i) engaging the generic drug industry and other involved stakeholders regarding how mechanistic modeling and simulation can support their product development and regulatory submissions; (ii) sharing the current state of mechanistic modeling for bioequivalence (BE) assessment through case studies; (iii) establishing a consensus on best practices for using mechanistic modeling approaches, such as physiologically based pharmacokinetic modeling and computational fluid dynamics modeling, for BE assessment; and (iv) introducing the concept of a Model Master File to improve model sharing between model developers, industry, and the FDA. More than 1500 people registered for the workshop. Based on a postworkshop survey, the majority of participants reported that their fundamental scientific understanding of mechanistic models was enhanced, there was greater consensus on model validation and verification, and regulatory expectations for mechanistic modeling submitted in abbreviated new drug applications were clarified by the workshop.
A tool for the semantic annotation, validation and optimization of business process models
Authors: Di Martino Beniamino , Colucci Cante Luigi , Esposito Antonio , Graziano Mariangela 
Published: January 2023

AbstractThe adoption of the business process model notation for the description of internal workflows and procedures by both public administrations and private organizations is steadily growing, thanks to the simplicity of the standard and its consistent expressivity. However, the lack of semantic support from BPMN can pose important limitations to its efficient use, as ambiguities in task definitions and communications can lead to misinterpretations. Furthermore, there is the need to validate the BPMNs, to check their adherence to regulations, especially in public administration, and to verify their conformance to security and privacy constraints. In this work, we present SemPrAnn, a semantic annotation tool for BPMN that, exploiting domain ontologies and logical rules, provides the possibility to unambiguously identify concepts in workflows and to run inferential engines against them to enforce the rules. The manuscript presents the methodology applied for the implementation of the tool, the tool itself with its exposed functionalities, and a case study demonstrating its current capabilities.
Das komplizierte kindliche Mittelohrhämangiom
Authors: Yılmaz Topçuoğlu Miray-Su , Hornberger Cornelia , Lucena-Porcel Carlota , Baumann Ingo 
Published: January 2023

ZusammenfassungMittelohrhämangiome bei Kleinkindern sind selten. Die Kasuistik beschreibt einen dreijährigen Jungen mit einseitiger Hörminderung und rezidivierenden Paukenergüssen durch ein Mittelohrhämangiom. Dieses verursachte eine Sinusvenenthrombose, Osteomyelitis und Mastoiditis. Eine interdisziplinäre Behandlung erfolgte. Auch gutartige Läsionen des Mittelohrs können schwerwiegende, lebensbedrohliche Komplikationen aufgrund der engen nachbarschaftlichen anatomischen Beziehungen des Mittelohrs hervorrufen. Jede asymmetrische Hörminderung sollte deshalb stets genauer untersucht werden.
Drug consumption in German cities and municipalities during the COVID-19 lockdown: a wastewater analysis
Authors: Oertel Reinhard , Schubert Sara , Helm Björn , Mayer Robin , Dumke Roger , El-Armouche Ali , Renner Bertold 
Published: January 2023

AbstractAnalysis of illicit drugs, medicines, and pathogens in wastewater is a powerful tool for epidemiological studies to monitor public health trends. The aims of this study were to (i) assess spatial and temporal trends of population-normalized mass loads of illicit drugs and nicotine in raw wastewater in the time of regulations against SARS-CoV-2 infections (2020–21) and (ii) find substances that are feasible markers for characterizing the occurrence of selected drugs in wastewater. Raw sewage 24-h composite samples were collected in catchment areas of 15 wastewater treatment plants (WWTPs) in urban, small-town, and rural areas in Germany during different lockdown phases from April 2020 to December 2021. Parent substances (amphetamine, methamphetamine, MDMA, carbamazepine, gabapentin, and metoprolol) and the metabolites of cocaine (benzoylecgonine) and nicotine (cotinine) were measured. The daily discharge of WWTP influents were used to calculate the daily load (mg/day) normalized by population equivalents (PE) in drained catchment areas (in mg/1,000 persons/day). A weekend trend for illicit drugs was visible with higher amounts on Saturdays and Sundays in larger WWTPs. An influence of the regulations to reduce SARS-CoV-2 infections such as contact bans and border closures on drug consumption has been proven in some cases and refuted in several. In addition, metoprolol and cotinine were found to be suitable as marker substances for the characterization of wastewater. A change in drug use was visible at the beginning of the SARS-CoV-2 crisis. Thereafter from mid-2020, no obvious effect was detected with regard to the regulations against SARS-CoV-2 infections on concentration of drugs in wastewater. Wastewater-based epidemiology is suitable for showing changes in drug consumption during the COVID-19 lockdown.
The German hearing in noise test with a female talker: development and comparison with German male speech test
Authors: Mönnich Anna-Lena , Strieth Sebastian , Bohnert Andrea , Ernst Benjamin Philipp , Rader Tobias 
Published: January 2023

Abstract
Purpose
The aim of the study was to develop the German Hearing in Noise Test (HINT) with female speaker by fulfilling the recommendations by International Collegium of Rehabilitative Audiology (ICRA) for using a female speaker to create new multilingual speech tests and to determine norms and to compare these norms with German male speech tests—the male speakers HINT and the Oldenburg Sentence Test (OLSA).

Methods
The HINT with a female speaker consists of the same speech material as the male speaking HINT. After recording the speech material, 10 normal hearing subjects were included to determine the performance–intensity function (PI function). 24 subjects were part of the measurements to determine the norms and compare them with the norms of male HINT and OLSA. Comparably, adaptive, open-set methods under headphones (HINT) and sound field (OLSA) were used.

Results
Acoustic phonetic analysis demonstrated significant difference in mean fundamental frequency, its range and mean speaking rate between both HINT speakers. The calculated norms by three of the tested four conditions of the HINT with a female speaker are not significantly different from the norms with a male speaker. No significant effect of the speaker’s gender of the first HINT measurement and no significant correlation between the threshold results of the HINT and the OLSA were determined.

Conclusions
The Norms for German HINT with a female speaker are comparable to the norms of the HINT with a male speaker. The speech intelligibility score of the HINT does not depend on the speakers’ gender despite significant difference of acoustic–phonetic parameters between the female and male HINT speaker’s voice. Instead, the speech intelligibility rating must be seen as a function of the used speech material.
Impact of advanced Parkinson’s disease on caregivers: an international real-world study
Authors: Martinez-Martin Pablo , Skorvanek Matej , Henriksen Tove , Lindvall Susanna , Domingos Josefa , Alobaidi Ali , Kandukuri Prasanna L. , Chaudhari Vivek S. , Patel Apeksha B. , Parra Juan Carlos , Pike James , Antonini Angelo 
Published: January 2023

Abstract
Background
Caring for a partner or family member with Parkinson’s disease (PD) negatively affects the caregiver’s own physical and emotional well-being, especially those caring for people with advanced PD (APD). This study was designed to examine the impact of APD on caregiver perceived burden, quality of life (QoL), and health status.

Methods
Dyads of people with PD and their primary caregivers were identified from the Adelphi Parkinson’s Disease Specific Program (DSP™) using real-world data from the United States, Japan and five European countries. Questionnaires were used to capture measures of clinical burden (people with PD) and caregiver burden (caregivers).

Results
Data from 721 patient-caregiver dyads in seven countries were captured. Caregivers had a mean age 62.6 years, 71.6% were female, and 70.4% were a spouse. Caregivers for people with APD had a greater perceived burden, were more likely to take medication and had lower caregiver treatment satisfaction than those caring for people with early or intermediate PD; similar findings were observed for caregivers of people with intermediate versus early PD. Caregivers for people with intermediate PD were also less likely to be employed than those with early PD (25.3% vs 42.4%) and spent more time caring (6.6 vs 3.2 h/day).

Conclusions
This real-world study demonstrates that caregivers of people with APD experience a greater burden than those caring for people with early PD. This highlights the importance of including caregiver-centric measures in future studies, and emphasizes the need for implementing treatments that reduce caregiver burden in APD.
Trial registration: N/A.
The PoliTO–UniRoma1 database of cyclic and dynamic laboratory tests: assessment of empirical predictive models
Authors: Ciancimino Andrea , Cosentini Renato Maria , Foti Sebastiano , Lanzo Giuseppe , Pagliaroli Alessandro , Pallara Oronzo 
Published: January 2023

AbstractThe soil nonlinear hysteretic behaviour is usually described, in the moderate strain range, through the shear modulus reduction and material damping ratio (MRD) curves. In common practice, in absence of specific laboratory tests, the curves are estimated by employing empirical regression models. Such predictive models, typically calibrated on large experimental datasets, correlate the soil response to its physical properties. This research fits within this context, presenting a comprehensive database of cyclic and dynamic laboratory tests conducted on natural Italian soils. The database, publicly available as supplementary data of the paper, contains the results of the tests conducted by the geotechnical laboratories of the Politecnico di Torino (Turin, Italy) and theSapienzaUniversità di Roma (Rome, Italy) over the past 30 years. The experimental data are employed to assess the performance of some widely used empirical models in predicting the MRD curves of natural uncemented fine-grained soils, emphasizing the importance of using an independent dataset for conducting a reliable statistical analysis. The results show that the use of many soil parameters as proxies for predicting the soil response does not necessarily lead to an improvement in the performance of the model. Therefore, according to Occam’s razor principle, simple models are to be preferred.
Rethinking the Place of Qualitative Methods in Behavior Analysis
Authors: Burney Victoria , Arnold-Saritepe Angela , McCann Clare M. 
Published: January 2023

AbstractSingle-case design research is pervasive and dominant in the field of behavior analysis (BA). It allows for effective application of behavior change technologies in a wide variety of real-world settings. However, as the field has grown, behavioral scholars have suggested incorporating other methods into the investigator’s toolbox to supplement single-case design. To date, the call to expand beyond using only variations of single-case design as the standard for behavior analytic research has gone largely unheard. Given the need for behavior analytic work to be more closely aligned with consumer and stakeholder needs and priorities, along with a proliferation of practitioners and researchers in the field, now is the time to consider the benefits of qualitative research methods for behavior analysts. In particular, in areas of social validity and in exploring diverse applied topics, qualitative methods may help the field of behavior analysis to achieve greater success with documenting the outcomes from behavior change interventions. The present article explores areas where behavior analysis may benefit from utilizing qualitative methods, namely social validity and breadth of topics for study, and provides examples of the value of qualitative research from other fields. A brief outline of qualitative research is provided alongside consideration of the seven dimensions of applied behavior analysis. In situations where single-case design does not offer behavior analysts sufficient methodological opportunity, qualitative research methods could form a powerful addition to the field of behavior analysis.
Young People’s Understanding of Coercive Control in Northern Ireland
Authors: Lagdon Susan , Klencakova Lucia , Schubotz Dirk , Shannon Ciaran , Tully Mark A. , Armour Cherie , Jordan Julie-Ann 
Published: January 2023

AbstractCoercive control and related research have progressed significantly in the past number of years, with an ever-growing evidence base adding to its construct. However, currently there is a lack of evidence on young people’s knowledge and understanding of coercive control. We included a module of questions in the 2020 Northern Ireland Young Life and Life and Times survey (n = 2,069) with the aim of capturing baseline measurable data on understanding of coercive control within intimate relationships among 16-year olds. Only 16% (n = 325) of respondents had heard of the term coercive control and knew what it meant. Findings also revealed that females, compared to males, were less likely to have heard of coercive control. When the victim being subjected to the behaviours was portrayed as female as opposed to male there was stronger recognition of the associated risks, need for support, and the seriousness of the situation. Our study findings call to question young people’s knowledge of unhealthy intimate relationship behaviours beyond blatant and deliberate acts of harm such as those described in the coercive control scenarios. Gender disparities in awareness of coercive control across the study sample also give cause for concern given the increased risk of intimate partner violence among women and girls as well as lower reporting and help seeking among male victims. Results solidify the necessity for dedicated preventative and intervention efforts which focus on intimate relationships and reflect the diverse needs and experiences of young people. Supporting young people to act on their own behalf is an important step change to empowerment within their own intimate relationships.
In-line measurement of extrusion force and use for nozzle comparison in filament based additive manufacturing
Authors: Fischer Jonas , Echsel Markus , Springer Patrick , Refle Oliver 
Published: January 2023

AbstractIn fused filament fabrication (FFF), it is important to control the extrusion process for different materials and extruder hardware precisely. The effective extrusion force on the nozzle allows the characterization of the flow behaviour of the molten polymer. Therefore, integrating compact force sensors into the extrusion unit allows the identification of suitable process windows for different materials and the evaluation of hardware. However, actual setups are not compact and restriction-free. This paper presents a new compact and concentric setup, which allows an accurate measurement of the forces in the extruder avoiding parasitic effects. Furthermore, the test rig and the calibration process including influencing factors such as filament contact force and extrusion height is described. On this basis, a varying parameter study using different nozzles, feeding velocities, and temperatures is conducted. The recorded values of the extrusion force are compared with the literature values and the flow behaviour is assigned to the corresponding nozzle geometry. It has been shown that the calibrated test rig is able to measure the extrusion force with sufficient accuracy. These measurements correspond to comparable literature values. The boundary conditions of feeding velocity for processing a specific material and nozzle are determined. In this way, requirements such as the fastest or a uniform extrusion can be specifically served by varying the corresponding parameters. An evaluation of the effects in the nozzles results in a nozzle performance overview.
Parametric models and information geometry on W*-algebras
Authors: Ciaglia F. M. , Di Nocera F. , Jost J. , Schwachhöfer L. 
Published: January 2023

AbstractWe introduce the notion of smooth parametric model of normal positive linear functionals on possibly infinite-dimensional $$W^{\star }$$

W
⋆

-algebras generalizing the notions of parametric models used in classical and quantum information geometry. We then use the Jordan product naturally available in this context in order to define a Riemannian metric tensor on parametric models satsfying suitable regularity conditions. This Riemannian metric tensor reduces to the Fisher–Rao metric tensor, or to the Fubini-Study metric tensor, or to the Bures–Helstrom metric tensor when suitable choices for the $$W^{\star }$$

W
⋆

-algebra and the models are made.
Robustness of Significant Dichotomous Outcomes in Randomized Controlled Trials in the Treatment of Patients with COVID-19: A Systematic Analysis
Authors: Liu Qi , Chen Hong , Gao Yonghua , Zhu Changju 
Published: January 2023

Abstract
Purpose
Significant results of randomized controlled trials (RCTs) should be properly weighed. This study adopted fragility index (FI) to evaluate the robustness of significant dichotomous outcomes from RCTs on coronavirus disease 2019 (COVID-19) treatment.

Materials and methods
ClinicalTrials.gov and PubMed were searched from inception to July 31, 2021. FIs were calculated and their distribution was depicted. FI’s categorical influential factors were analyzed. Spearman correlation coefficient (rs) was reported for the relationship between FI and the continuous characteristics of RCTs.

Results
Fifty RCTs with 120 outcomes in 7869 patients were included. The FI distribution was abnormal with median 3 (interquartile range 1–7, P = 0.0001). The FIs and robustness were affected by the outcomes of interest, various patient populations, and interventions (T = 18.215,16.667, 23.107; P = 0.02,0.0001, 0.001, respectively). A cubic relationship between the FIs and absolute difference of events between groups with R square of 0.848 (T = 215.828, P = 0.0001, R square = 0.865) was observed. A strong negative logarithmic relationship existed between FI and the P value with R square = – 0.834.

Conclusion
The robustness of significant dichotomous outcomes of COVID-19 treatments was fragile and affected by the outcomes of interest, patients, interventions, P value, and absolute difference of events between the groups. FI was an useful quantitative metric for the binary significant outcomes on COVID-19 treatments.

Registration
PROSPERO (CRD42021272455).
Social Policy in a Climate Emergency Context: Towards an Ecosocial Research Agenda
Authors: Hirvilammi Tuuli , Häikiö Liisa , Johansson Håkan , Koch Max , Perkiö Johanna 
Published: January 2023

AbstractSocial policy developed as a research field and academic discipline to ensure protection from social risks in the era of emerging capitalism and industrialization. While welfare states have successfully increased their citizens’ wellbeing, they have also contributed to the ecological crisis, while the shared scientific understanding of exceeded planetary boundaries and worsening climate change scenarios has not (yet) reshaped mainstream social policy research. In this article, we suggest that the established traditions in social policy research can nevertheless provide a solid ground for responding to the climate emergency and facilitating the sustainable transformation of society and the economy. With a focus on four of the research fields that are central in social policy scholarship – risks, citizenship, welfare regimes, and wellbeing – we develop an ecosocial research agenda. By discussing the classic and climate-adjusted understandings of these fields, we open future pathways for social policy research and invite scholars to engage with our proposed research agenda.
Enhancing adolescent parent interactions in communication through facilitative playgroups
Authors: ABARCA Diana , ALLEN Kasey , TOWSON Jacqueline A. , GREEN Katherine B. 
Published: January 2023

AbstractAdolescent pregnancy can impact the educational attainment of adolescent mothers and language development of their children. However, support services and interventions can mitigate these risk factors. Adolescent mothers have shown success in implementing various language facilitation strategies (LFS) with their children when coached. We developed a triadic language intervention in a facilitated playgroup context to support adolescent mothers’ use of language strategies when interacting with their children. The current pilot study utilized a pre-test, post-test descriptive approach to analyze differences in adolescent mothers’ language use and parenting behaviors and their children’s language use after participation in facilitated playgroups. All adolescent mothers demonstrated enhanced parenting practices. Changes in mothers’ and children’s language from pre- to post-test were variable across participants. While this pilot study shows promising evidence of the utility of a triadic intervention situated in playgroups with adolescent families, further research is required to address the limitations of this study.