bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the contribution of aroma‐active and chiral compounds to different grade of Yashi Xiang teas using stir bar sorptive extraction
Authors: Xiao ZuoBing , Yang EnQing , Niu YunWei , Zhu JianCai 
Published: July 2023

AbstractYashi Xiang (YSX) is a flavor of Fenghuang Dancong tea and famous for its name and floral aroma, which is a type of semi‐fermented oolong tea. However, previous research into the aroma characteristics of YSX tea mostly focused on the aroma compounds, and little research on chiral compounds in YSX has been performed. Therefore, the current study was conducted to explore the aroma characteristics of YSX tea from the perspective of enantiomers of chiral compounds. A total of 12 enantiomers were determined in this study, among them, (R)‐(‐)‐α‐ionone, (S)‐(+)‐linalool, (1S,2S)‐(+)‐methyl jasmonate, (S)‐z‐nerolidol, (R)‐(+)‐limonene, and (S)‐(‐)‐limonene have important effects on the aroma components of YSX tea. The ER ratios of the enantiomers were different in samples of different grades. Therefore, this parameter can be used to identify the grade and authenticity of YSX tea.Practical ApplicationThe study illuminates the aroma characteristics of YSX tea from the perspective of enantiomers of chiral compounds, which have important effects on the aroma components of YSX tea. It established an ER ratio system to effectively distinguish the grade and authenticity of YSX tea by comparing the ER of YSX tea. Focusing on analyzing the chiral compounds in the aroma of YSX tea is helpful in providing a theoretical basis for the authenticity of the precious tea and improving of the quality of YSX tea products.
Evaluation and comparison of physicochemical properties, volatile substances, and microbial communities of leaf mustard (Brassica juncea var. multiceps) under natural and inoculated fermentation
Authors: Lingjuan Jiang , Yu Cao , Zeyuan Deng , Bing Zhang , Hongyan Li 
Published: July 2023

AbstractDue to the uncontrolled fermentation process and unstable quality of naturally fermented leaf mustard, inoculated fermentation is receiving more attention. Here, the physicochemical properties, volatile compounds, and microbial community in leaf mustard under natural fermentation (NF) and inoculated fermentation (IF) were analyzed and compared. The contents of total acid, crude fiber, and nitrite of leaf mustard were measured. Headspace‐solid phase microextraction–gas chromatography–mass spectrometry and orthogonal projection on latent structure–discriminant analysis were used to analyze the differences of volatile compounds in NF and IF leaf mustard. Moreover, Illumina MiSeq high‐throughput sequencing technology was employed to reveal the composition of microbiota. The results showed that the nitrite content in leaf mustard after IF (3.69 mg/kg) was significantly lower than that after NF (4.43 mg/kg). A total of 31 and 25 kinds of volatile components were identified in IF and NF, respectively. Among the detected compounds, 11 compounds caused the differences between IF and NF leaf mustard. The results of inter‐group difference analysis showed that there were significant differences in fungal flora between IF and NF samples. Saccharomycetes, Kazachstania, and Ascomycota were the landmark microorganisms in IF leaf mustard and the landmark microorganisms in NF were Mortierellomycota, Sordariomycetes, and Eurotiomycetes. The abundance of probiotics (such as Lactobacillus) in IF leaf mustard (51.22%) was higher than that in NF (35.20%) and the abundance of harmful molds (such as Mortierella and Aspergillus) was opposite. Therefore, IF leaf mustard showed the potential to reduce the content of nitrite and harmful molds and increase the beneficial volatile compounds and probiotics.Practical ApplicationLeaf mustard of inoculated fermentation (IF) showed better fermented characteristics than natural fermentation in terms of lower nitrite content, greater beneficial volatile substances, and better potential for increasing probiotics and reducing harmful molds. These results provided a theoretical basis for IF leaf mustard and contributed to the industrial production of fermented leaf mustard.
Misdiagnosis and delayed diagnosis of atypical autoimmune pancreatitis: Experience from clinical cases
Authors: Xu Zi‐Yang , Guan Jiao , Liang Ming‐Jun , Zhang Zheng‐Yun , Zhou Zun‐Qiang 
Published: July 2023

AbstractAutoimmune pancreatitis (AIP) is a fibro‐inflammatory disease characterized by inflammation and fibrosis of the pancreas. It is a systemic disease that can affect multiple organs, including the bile ducts, kidneys, lungs, and other organs. However, due to its complex presentation, AIP is often challenging to diagnose, and misdiagnosis with pancreatic tumors can occur. In our study, we reviewed three cases of atypical AIP where patients had normal serum IgG4 levels, leading to initial misdiagnosis with pancreatic tumors. Delayed diagnosis resulted in irreversible pathologies such as retroperitoneal fibrosis. All three patients had bile duct involvement, and imaging findings were similar to those of tumors, further complicating the diagnosis. The correct diagnosis was confirmed only after diagnostic therapy. Our study aims to raise awareness of atypical AIP and improve diagnostic efficiency by analyzing the clinical characteristics of these patients.
TTC4 inhibits NLRP3 inflammation in rheumatoid arthritis by HSP70
Authors: Lu Hui , Lu Xin , Xie Qihua , Wan Honglai , Sun Yuyu 
Published: July 2023

AbstractObjectiveThis experiment explored the function of TTC4 in rheumatoid arthritis inflammation and its possible mechanism.MethodsC57BL/6 mice were immunized intradermally with bovine type II collagen. Lipopolysaccharide induction was performed on RAW264.7 cells.ResultsThe mRNA expression of TTC4 in articular tissue of mice with rheumatoid arthritis was downregulated. Sh‐TTC4 virus increased arthritis score, morphological change score, paw edema, and spleen index, as well as alkaline phosphatase level in mice with rheumatoid arthritis. Sh‐TTC4 virus increased the levels of inflammatory factors and MDA, and decreased anti‐oxidant factors in articular tissue of mice with rheumatoid arthritis. TTC4 reduced inflammation and oxidative stress in an in vitro model. TTC4 regulated HSP70 in a rheumatoid arthritis model. The inhibition of HSP70 reduced the effects of sh‐TTC4 gene in mice with rheumatoid arthritis. METTL3 reduced the stability of the TTC4 gene.ConclusionIn this study, the TTC4 gene reduced oxidative response and inflammation in the rheumatoid arthritis model through the HSP70/NLRP3 pathway. Therefore, it can be concluded that TTC4 can be used as diagnosis and prognosis evaluation of rheumatoid arthritis.
Ireland: Political Developments and Data in 2022
Authors: ARLOW JONATHAN , O'MALLEY EOIN 
Published: July 2023

AbstractIreland in 2022 saw the return of normal politics after two years of the pandemic. The ebbing of the health crisis saw the emergence or re‐emergence of new crises. The invasion of Ukraine had an impact on Irish politics as there was a surge of refugees accommodated in Ireland and an increase in inflation. The government introduced measures to mitigate the impact of the cost‐of‐living crisis, but the growing population and a lag in construction activity caused the housing crisis to worsen. None of what the government sought to do was able to mitigate these problems in the short to medium term at least. By the end of the year, the pressure the number of refugees had put on housing services led to anti‐refugee protests, hitherto unknown in Ireland. Ireland also saw a new Taoiseach (Prime Minister), though the government remained substantively the same following the planned rotation of the head of government.
Residence in a Medicaid‐expansion state and receipt of alcohol screening and brief counseling by adults with lower incomes: Is increased access to primary care enough?
Authors: Phillips Aryn Z. , Karriker‐Jaffe Katherine J. , Bensley Kara M. K. , Subbaraman Meenakshi S. , Delk Joanne , Mulia Nina 
Published: July 2023

AbstractBackgroundWe investigate whether living in a state that expanded Medicaid eligibility is associated with receiving alcohol screening and brief counseling among nonelderly, low‐income adults and a subgroup with chronic health conditions caused or exacerbated by alcohol use.MethodData are from the 2017 and 2019 Behavioral Risk Factor Surveillance System (N = 15,743 low‐income adults; n = 7062 with a chronic condition). We used propensity score‐weighted, covariate‐adjusted, modified Poisson regression to estimate associations between residence in a Medicaid‐expansion state and receipt of alcohol screening and brief counseling. Models estimated associations in the overall sample and chronic conditions subsample, as well as differential associations across sex, race, and ethnicity using interaction terms.ResultsLiving in a state that expanded Medicaid eligibility was associated with being asked whether one drank (prevalence ratio (PR) = 1.15, 95% confidence interval (CI) = 1.08, 1.22), but not with further alcohol screening, guidance about harmful drinking, or advice to reduce drinking. Among individuals with alcohol‐related chronic conditions, expansion state residence was associated with being asked about drinking (PR = 1.13, 95% CI = 1.05, 1.20) and, among past 30‐day drinkers with chronic conditions, being asked how much one drank (PR = 1.28, 95% CI = 1.04, 1.59) and about binge drinking (PR = 1.43, 95% CI = 1.03, 1.99). Interaction terms suggest that some associations differ by race and ethnicity.ConclusionsLiving in a state that expanded Medicaid is associated with a higher prevalence of receiving some alcohol screening at a check‐up in the past 2 years among low‐income residents, particularly among individuals with alcohol‐related chronic conditions, but not with the receipt of high‐quality screening and brief counseling. Policies may have to address provider barriers to delivery of these services in addition to access to care.
Laparoscopic repair of acquired rectourethral fistula by vesical peritoneal flap
Authors: Mouawad Christian , El Helou Elie , Dahboul Houssam , Akel Rhea , Chamaa Bilal , Aoun Rany , Kassar Serge , Osseis Michael , Noun Roger , Chakhtoura Ghassan 
Published: July 2023

AbstractIntroductionA rectourethral fistula (RUF) is an infrequent complication that can be iatrogenic in most cases. Multiple surgical interventions were described for RUF repair including transsphincteric, transanal, transperineal, and transabdominal approaches. To this day, there is no consensus on a standardized surgery of choice for acquired RUF.Materials and Surgical TechniqueOur patient was diagnosed with RUF 4 weeks after undergoing laparoscopic low anterior resection for midrectum adenocarcinoma, with failure of conservative treatment. A three‐port transabdominal approach was used to dissect the rectoprostatic space and close the fistula orifice on the anterior rectal wall. With the technical impossibility to develop an omental flap, the peritoneum on the posterior vesical wall was carefully dissected to form a rectangular flap pedicled by its inferior aspect. The harvested peritoneal flap was then anchored between the prostate and the rectum. Follow‐up imaging showed the absence of RUF, concurrently with total remission of RUF symptomatology.DiscussionManagement of acquired RUF can be challenging, especially after failure of conservative treatment. Laparoscopic repair of acquired RUF by vesical peritoneal flap is a valid option for a minimally invasive approach for the treatment of RUF.
Explaining Transmission Rate Variations and Forecasting Epidemic Spread in Multiple Regions with a Semiparametric Mixed Effects SIR Model
Authors: Buch David A. , Johndrow James E. , Dunson David B. 
Published: July 2023

Abstract
The transmission rate is a central parameter in mathematical models of infectious disease. Its pivotal role in outbreak dynamics makes estimating the current transmission rate and uncovering its dependence on relevant covariates a core challenge in epidemiological research as well as public health policy evaluation. Here, we develop a method for flexibly inferring a time-varying transmission rate parameter, modeled as a function of covariates and a smooth Gaussian process (GP). The transmission rate model is further embedded in a hierarchy to allow information borrowing across parallel streams of regional incidence data. Crucially, the method makes use of optional vaccination data as a first step toward modeling of endemic infectious diseases. Computational techniques borrowed from the Bayesian spatial analysis literature enable fast and reliable posterior computation. Simulation studies reveal that the method recovers true covariate effects at nominal coverage levels. We analyze data from the COVID-19 pandemic and validate forecast intervals on held-out data. User-friendly software is provided to enable practitioners to easily deploy the method in public health research.
Lobar quantification of pulmonary perfusion prior to minimally invasive lung reduction improves prediction of postprocedure outcomes: A pilot study
Authors: Subramanian Kritika , Muench Brett , Shostak Eugene , Coffey Amanda , Sawoszczyk Lady , Gao Fei , Leep Adam , Rajaram Ramya , Hornung John , O'Dwyer Elisabeth 
Published: July 2023

AbstractBackgroundEndobronchial valve placement is a minimally invasive option for treatment of patients with severe emphysema, by reducing lung volumes in lobes with both poor ventilation and perfusion; ventilation is determined by emphysematous scores and perfusion by quantitative lung perfusion imaging. CT‐based fissure identifying artificial intelligence algorithms have recently demonstrated enhanced quantification of the perfusion in a 5‐lobar analysis. We hypothesized that this newly developed algorithm may offer greater utility in determining target treatment lobes by supplementing the radiographic risk stratification initiated by the conventional emphysematous scores alone.MethodsQuantification images of 43 deidentified individuals underwent perfusion SPECT/CT with Tc99m Macro‐Aggregated Albumin (4mCi/148MBq intravenous) using both conventional zonal anatomy and AI augmented 5‐lobar analysis.AnalysisImages were reviewed to demonstrate that the new algorithm was not inferior to standard of care imaging with zonal segmentation. A pilot subcohort analysis of 4 patients with severe emphysema who had pre‐endobronchial valve placement imaging demonstrated that an emphysema‐perfusion ratio greater than 3 was indicative of a potential target lobe.DiscussionWe conclude that 5‐lobar analysis in not inferior to conventional zonal analysis and allows the determination of emphysema‐to‐perfusion ratio. Preliminary review of a small subcohort suggests an emphysema‐to‐perfusion ratio greater than 3 for a lobe may clinically benefit in endobronchial valve placement. Further evaluation with prospective studies and larger sample sizes are recommended before clinical implementation.
Successful transplantation of LUCAS device assisted uncontrolled DCD kidneys with prolonged relative warm ischemia time: An underutilized option in North America
Authors: Nagaraju Santosh , Savilla Rachel , Moore Myla , Jones Alice , Africa Joseph 
Published: July 2023

AbstractApproximately 25% of deceased donors in the United States are procured in a donation after circulatory death (DCD) setting. Successful transplant outcomes from uncontrolled DCD (uDCD) practices have been reported in multiple European programs. They utilize established protocols for uDCD procurement with normo‐thermic or hypothermic regional perfusion to reduce ischemic damage. Further, manual or mechanical chest compressions using extrinsic devices, such as the LUCAS device, are implemented to maintain circulation before organ retrieval. Currently, uDCDs are not a major part of DCD organ utilization in the United States. We report our experience with utilization of kidneys from uDCD with the use of the LUCAS device without normothermic or hypothermic regional perfusion. We transplanted four kidneys from three uDCD donors without utilization of in situ regional perfusion and with prolonged relative warm ischemia time (rWIT) (>100 min). All recipients had functional renal allografts and improved renal function after the transplant. To our knowledge, this is the 1st successful series reported in the United States of the utilization of kidneys from uDCDs without the utilization of in situ perfusion to maintain organ preservation with prolonged rWIT.
Dental and maxillofacial injuries associated with domestic violence against women in Israel: A report for 2011–2021
Authors: Levin Liran , Goldman Sharon , Lin Shaul , Radomislensky Irina , Savitsky Bella 
Published: July 2023

AbstractBackground/AimThe WHO, in its 2002 report, indicated the dramatic worldwide increase in the incidence of intentional injuries affecting people of all ages and both sexes, but especially children, women, and the elderly. The aim of this study was to analyze dental and maxillofacial injuries associated with domestic violence against women in Israel between the years 2011–2021.MethodsThis was a retrospective cohort study based on data from the Israeli National Trauma Registry (INTR). The INTR provides comprehensive data on hospitalized patients from all six Level I trauma centers (TC) and 15 of the 20 Level II TCs in Israel. Women, ages 14 and older, injured and hospitalized due to domestic violence between 2011 and 2021 were identified.ResultsBetween 2011 and 2021, there were 1818 cases of women ages 14 + that were hospitalized due to violence, excluding terror, occupational trauma, and attempted suicide. Out of these injuries, 753 cases were attributed to domestic violence, 537 were defined as non‐domestic violence and 528 were a result of a brawl/fight. Of the domestic violence cases, 5% (38) exhibited maxillofacial injuries compared to the non‐domestic violence cases where 6.2% (33) exhibited maxillofacial injuries and the brawl group where 5.7% (30) exhibited maxillofacial injuries. The most injured areas in domestic violence cases were the maxilla followed by the zygomatic bone and the mandible. Almost half of the domestic violence cases (47.7%) required surgical intervention during their hospitalization. The spouse was the perpetrator responsible for the domestic violence in the majority of the cases.ConclusionsDental professionals might be able, in some cases, to identify and report domestic violence signs and thus, better understanding of the specific characteristics of domestic violence related to traumatic injuries is important.
Understanding the role of gender and project characteristics in research funding evaluations
Authors: Foss Nicolai J. , Olsen Anders Ørding 
Published: July 2023

AbstractResearch shows that women are less successful than men in obtaining external funding for research projects. However, other research points to advantages of female leadership and suggests that women are capable of breaking glass ceilings in competitive contexts (e.g., promotions). We bridge these ideas by arguing that although women are disadvantaged in the funding process (e.g., as principal investigators or PIs), there may be advantages of female representation in research projects that compete for funding. We analyze a unique panel dataset based on all call texts and all applications to the “Cooperation” part of the EU FP7, a 2007–2013 EUR 53.2 billion program. Using fixed‐effects regressions, we find that projects with high female representation (or with female PIs) receive less favorable evaluations. However, this effect weakens as the relevant projects become more heterogeneous and radical. These findings are robust to a number of alternative specifications.
Cyclin D1 promotes radioresistance through regulation of RAD51 in melanoma
Authors: Im Hyuntaik , Lee Jeeyong , Lee Hae Jin , Kim Da Yeon , Kim Eun Ju , Yi Jae Youn 
Published: July 2023

AbstractMelanoma is a notoriously radioresistant type of skin cancer. Elucidation of the specific mechanisms underlying radioresistance is necessary to improve the clinical efficacy of radiation therapy. To identify the key factors contributing to radioresistance, five melanoma cell lines were selected for study and genes that were upregulated in relatively radioresistant melanomas compared with radiosensitive melanoma cells determined via RNA sequencing technology. In particular, we focused on cyclin D1 (CCND1), a well known cell cycle regulatory molecule. In radiosensitive melanoma, overexpression of cyclin D1 reduced apoptosis. In radioresistant melanoma cell lines, suppression of cyclin D1 with a specific inhibitor or siRNA increased apoptosis and decreased cell proliferation in 2D and 3D spheroid cultures. In addition, we observed increased expression of γ‐H2AX, a molecular marker of DNA damage, even at a later time after γ‐irradiation, under conditions of inhibition of cyclin D1, with a response pattern similar to that of radiosensitive SK‐Mel5. In the same context, expression and nuclear foci formation of RAD51, a key enzyme for homologous recombination (HR), were reduced upon inhibition of cyclin D1. Downregulation of RAD51 also reduced cell survival to irradiation. Overall, suppression of cyclin D1 expression or function led to reduced radiation‐induced DNA damage response (DDR) and triggered cell death. Our collective findings indicate that the presence of increased cyclin D1 potentially contributes to the development of radioresistance through effects on RAD51 in melanoma and could therefore serve as a therapeutic target for improving the efficacy of radiation therapy.
A creep constitutive model for heterogeneous frozen clay soil considering the damage of cryostructure
Authors: Shi Sheng , Zhang Feng , Feng Decheng 
Published: July 2023

AbstractIn cold regions, the creep behavior of frozen soil is a crucial indicator for evaluating the stability of engineering foundations. The creep properties of frozen soil are more complex than unfrozen soil owing to its special cryogenic structures. In this research, a series of creep tests were conducted on the heterogeneous frozen clay soil under different deviatoric stresses, and the influence of deviatoric stress and structural features on its creep behaviors were analyzed. Based on the test results and fracture mechanics, the damage variable of heterogeneous frozen clay soil considering the effect of cryostructure was defined, and the sensitivity of parameters in damage variable were analyzed. By introducing the hardening variable and damage variable into the classical Nishihara model, a new creep constitutive model for heterogeneous frozen clay soil considering the fracture of cryostructure was established, the validity of the model was verified using test results, and the model parameters were analyzed.