bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of the National Syphilis Prevention Program on the prevalence of syphilis among people living with HIV in China: a systematic review and meta‐analysis
Authors: Zeng Qingling , Yang Yuhui , Zhang Limin , Yan Jiangyu , Wang Jian , Nie Jingmin , Wang Qingmei , Luo Yu , Li Gaoming 
Published: January 2025

AbstractIntroductionIn 2010, China launched the 10‐year National Syphilis Prevention and Control Program to curb the spread of syphilis by integrating syphilis screening and treatment with HIV services. Herein, we aimed to evaluate changes in the prevalence of syphilis among people living with HIV (PLHIV) in China.MethodsWe conducted this systematic review and meta‐analysis by searching the PubMed, Embase, Web of Science, China Biomedical Literature, China National Knowledge Infrastructure, Wanfang and CQVIP databases from inception to 1 June 2024 to obtain relevant articles. A total of 75 studies were ultimately included. We used a DerSimonian‒Laird random effects model to estimate the prevalence and 95% confidence interval of syphilis among PLHIV.ResultsThe overall prevalence of syphilis among PLHIV in China was 18.6% (95% CI 16.5–21.0). Regional differences (R2 = 15.29%) were observed in the prevalence rates: 22.2% (18.9–25.8) in the eastern region, 19.0% (15.1–23.8) in the central region and 14.0% (11.1–17.5) in the western region. The prevalence decreased from 22.8% (18.4–27.9) before 2010 to 17.0% (14.6–19.6) in 2010 and thereafter (R2 = 5.82%). Among PLHIV via homosexual transmission, the prevalence of syphilis was 24.9% (21.3–28.9), which significantly declined from 33.8% (27.5–40.8) to 21.4% (18.3–24.9) in 2010 and thereafter (R2 = 22.35%). The prevalence of syphilis was significantly higher in men living with HIV than in women living with HIV (pooled odds ratio 1.67, 95% CI 1.29–2.15), with the highest prevalence in the eastern region (2.55, 95% CI 1.80–3.59).DiscussionThe prevalence of syphilis among PLHIV, particularly in cases of homosexual transmission, has declined. There was a correlation between the prevalence of syphilis and regional economic conditions, with a greater burden in developed eastern coastal areas. Additionally, the risk of syphilis differed across sexes, with men living with HIV having a higher risk.ConclusionsThere has been preliminary success in the control of syphilis among PLHIV, but there is still a long way to go to meet the WHO's 2030 syphilis prevention and control goal. Syphilis prevention measures should be integrated into broader health policies and development plans, particularly in high‐burden regions and populations.
Novel Insights Into Gyrate Atrophy of the Choroid and Retina (GACR): A Cohort Study
Authors: Balfoort Berith M. , Van den Broeck Filip , Boon Camiel J. F. , Brouwers Martijn C. G. J. , Diederen Roselie M. H. , Dhillon Preet ,   GACR “Bird's Eye View” Consortium, van Hasselt Peter M. , Jaeger Bregje , Karuntu Jessica S. , Rennings Alexander J. M. , van Spronsen Francjan J. , Timmer Corrie , Wagenmakers Margreet A. E. M. , De Zaeytijd Julie , Leroy Bart P. , Schulze Andreas , van Karnebeek Clara D. , Brands Marion M. 
Published: January 2025

ABSTRACTGyrate atrophy of the choroid and retina (GACR, OMIM #258870) is a rare inherited metabolic disorder characterized by progressive chorioretinal degeneration and hyperornithinemia. Current therapeutic modalities potentially slow disease progression but are not successful in preventing blindness. To allow for trial development, increased knowledge of the clinical phenotype and current therapeutic outcomes is required. In this study, we analyzed 27 patients with GACR. The median age at inclusion was 24 years (range 8–58), with a median age at diagnosis of 14 years (range 0–42). Symptoms began at a mean age of 9 years (range 0–21). Mixed‐models analysis showed a significant association between dietary natural protein intake and plasma ornithine levels. Ornithine increased significantly with age, independent of dietary natural protein intake. We found no statistically significant association between ornithine levels and best‐corrected visual acuity over time. Patients who started a natural protein‐restricted diet below 10 years of age had better VF outcomes compared to patients that started at a later age. MR spectroscopy was used to asses cerebral creatine deficiency, which was present in 15/20 patients, of whom 10 were supplemented with creatine at the time. Finally, using the Michigan Retinal Degeneration Questionnaire, we provided a first insight into the vision‐related disability reported by patients with GACR and showed that higher foveal sensitivity was associated with less perceived disability. To conclude, this study provides insights into the phenotype, genotype, biochemistry, and treatment effects of GACR, which can be used for care pathways and clinical trial design.
Metabolic Risk Factors Relate to Worse Tendon Health in Individuals With Achilles Tendinopathy
Authors: Seymore Kayla D. , Smitheman Hayley Powell , Smith Andy K. , Pohlig Ryan T. , Couppé Christian , Silbernagel Karin Grävare 
Published: January 2025

ABSTRACTA high proportion of individuals with Achilles tendinopathy continue to demonstrate long‐term symptoms and functional impairments after exercise treatment. Thus, there is a need to delineate patient presentations that may require alternative treatment. The objective of this study was to evaluate if the presence of metabolic risk factors relates to tendon symptoms, psychological factors, triceps surae structure, and lower limb function in individuals with Achilles tendinopathy. One hundred and fifty‐eight individuals (88 female) with diagnosed midportion Achilles tendinopathy were divided into three groups based on the number of metabolic risk factors linked to cardiovascular disease present at baseline: two or more factors, one factor, no factors. Metabolic risk factors were determined by clinical evaluation and past medical history. Achilles tendinopathy symptoms (Victorian Institute of Sport Assessment‐Achilles, Patient Reported Outcome Measurement Information System, movement‐evoked pain ratings), psychological factors (Tampa Scale for Kinesiophobia), triceps surae structure (B‐mode ultrasound of tendon and muscle morphology, continuous shear wave elastography of tendon mechanical properties), and lower limb function (test battery) were compared among groups. Individuals with two or more metabolic risk factors had worse symptoms with loading (p = 0.011), smaller Achilles tendon size relative to body mass (p = 0.002), and worse lower limb function compared to individuals without metabolic risk factors (p < 0.02). No differences were observed between individuals with one metabolic risk factor and those without metabolic risk factors. Future consideration of multiple metabolic risk factors for individuals with Achilles tendinopathy could facilitate understanding the underlying impairments of tendon pathology and recovery that may be addressed with treatment.
Targeting SETDB1 in cancer and immune regulation: Potential therapeutic strategies in cancer
Authors: Pan Bo‐Syong , Lin Cheng‐Yu , Lee Gilbert Aaron , Lin Hui‐Kuan 
Published: January 2025

AbstractSET domain bifurcated histone lysine methyltransferase 1 (SETDB1/ESET), a pivotal H3K9 methyltransferase, has been extensively studied since its discovery over two decades ago. SETDB1 plays critical roles in immune regulation, including B cell maturation, T‐cell activity modulation, and endogenous retrovirus (ERV) silencing. While essential for normal immune cell function, SETDB1 overexpression in cancer cells disrupts immune responses by suppressing tumor immunogenicity and facilitating immune evasion. This is achieved through the repression of anti‐tumor immune cell production, ERV silencing, and interference with the type I interferon pathway leading to inhibiting immune checkpoint blockade (ICB) efficacy. Beyond its immunological implications, SETDB1 overexpression fosters tumor growth and metastasis via transcriptional silencing of tumor suppressor genes through histone regulation and activating oncogenic signaling by non‐histone regulation. These multifaceted roles make SETDB1 an attractive epigenetic target for novel cancer therapies. This review explores SETDB1's dual function in immune regulation and tumor progression, emphasizing its potential in the development of innovative cancer treatments targeting epigenetic dysregulation and oncogenic signaling.
Activation or Rigidity: The Dual‐Channel Mechanism of Responsibility on Consumer Citizenship Behavior Beneficial to Community Members
Authors: Wei Helin , Liu Jiawen , Zhu Shaoying , Lyu Bei 
Published: January 2025

ABSTRACTIn recent years, private domain communities have become key hubs for connecting businesses and users. However, many private domain communities remain “rigid” rather than “activated,” limiting their marketing potential. This paper, grounded in psychological reactance theory, examines how dual‐channel responsibility affects consumer citizenship behavior beneficial to community members. Using surveys, experiments, and regression analysis across seven studies, the research shows that taking charge boosts freedom and promotes citizenship behavior beneficial to community members. In contrast, responsibility diffusion limits such behavior by imposing constraints. Community warmth moderates the effects of responsibility diffusion and taking charge on these behaviors.
High‐Density Polyethylene Janus Fibrous Membrane with Enhanced Breathability and Moisture Permeability via PDA Assisted Hydrophilic Modification
Authors: Liu Qingqing , Li Zhongde , Lu Tianyu , Zhu Qianqin , Mao Xiaohui , Zhu Liping , Wang Xuefen , Zhu Meifang 
Published: January 2025

AbstractFunctional fibrous membranes with high mechanical properties are intensively developed for different application fields. In this study, to enhance moisture and air permeability without compromising mechanical strength, a facile float‐surface modification strategy is employed to fabricate Janus fibrous membranes with distinct hydrophobicity/hydrophilicity using the high‐density polyethylene (HDPE) fibrous membranes. By coating one side of the HDPE fibrous membranes with polydopamine (PDA) and a superhydrophilic polyelectrolyte, the obtained Janus HDPE fibrous membranes demonstrate an excellent water transmission rate (577.61 ± 72.66 g m−2 h−1), water vapor transmission rate (WVTR, 131.62 ± 24.34 g m−2 h−1) and gas permeability (17,496 ± 235 m3 m−2 h−1 bar−1), which are much better than those commercial membranes (Tyvek with water transmission rate 518.93 ± 23.20 g m−2 h−1, WVTR 53.09 ± 6.19 g m−2 h−1, and gas permeability 2,871 ± 145 m3 m−2 h−1 bar−1). Further, the Janus HDPE fibrous membranes keep outstanding mechanical strength (17.00 ± 4.26 MPa of tensile strength, 45.49 ± 8.75% of strain at break), and exhibit an asymmetric wettability on each side which is demonstrated by the separation experiments with various oil‐water mixtures. This simple modification approach not only improves the serviceability of HDPE fibrous membranes but also offers scalable potential for apparel applications and other industrial applications.
Exploring Barriers to Innovative Marketing in MSMEs: An Analysis Using a BWM‐ISM Multi‐Criteria Decision‐Making Framework
Authors: Mondal Sourav , Singh Saumya , Gupta Himanshu 
Published: January 2025

ABSTRACTIn today's dynamic business landscape, organisations increasingly realise the pivotal role of innovative marketing approaches (IMA) in gaining a competitive edge and driving sustainable growth. However, many organisations encounter formidable barriers to adopting and developing IMA, despite the growing importance of innovative approaches in marketing. The purpose of this research is to identify, prioritise, establish the inter‐relationships and propose a ‘level‐wise structural model’ of the barriers that an organisation faces in adopting and developing IMA. The research employed a mix of quantitative and qualitative methods. An exhaustive review of related literature and theoretical frameworks (namely the ‘resource‐based view’ (RBV) theory, the ‘social capital theory’ (SCT) theory, the ‘innovation resistance theory’ (IRT) theory, and the ‘institutional theory’ (IT) theory), along with expert feedback, are used to categorise and finalise the barriers. Further, a case study from ‘micro, small and medium enterprises’ (MSMEs) in a developing nation such as India along with hybrid ‘multi‐criteria decision‐making’ (MCDM), that is, best‐worst method (BWM), was applied to prioritise the barriers. While ‘interpretive structural modelling’ (ISM) was used to establish contextual relationships, and ‘matrice d'impacts croisés multiplication appliquée á un classment’ (MICMAC) analysis was employed to cluster the barriers. The findings suggest that among the main category technology‐related barriers and from subcategories, infrastructure supports the top barriers and works as a driving obstacle while building IMA for sustainable development. The findings from this study can help develop effective marketing strategies that align profitability with environmental and social responsibility.
On the Solitons, Shocks, and Periodic Wave Solutions to the Fractional Quintic Benney–Lin Equation for Liquid Film Dynamics
Authors: Alyousef Haifa A. , Shah Rasool , Salas Alvaro H. , Tiofack C. G. L. , Ismaeel Sherif M. E. , Alhejaili Weaam , El‐Tantawy Samir A. 
Published: January 2025

ABSTRACTIn this study, two improved versions related to the family of ‐approaches , namely, the simple ‐expansion method and the generalized ‐expansion method, are applied to investigate the families of symmetric solitary wave solutions for the quintic fractional Benney–Lin equation that arises in the liquid film. The ‐expansion method is a transformation‐based method that has been used a lot to solve nonlinear partial differential equations and fractional partial differential equations. This method produces several solitary wave solutions to the current problem by supposing a series‐form solution. The generalized ‐expansion method, on the other hand, builds on the simple ‐expansion method by adding more parameters to the series‐form solution. This makes finding more families of solitary wave solutions possible and better shows how the system changes over time. These techniques identify various traveling waves, such as periodic, kink, ‐shaped, bell‐shaped, shock waves and others physical solutions. Some obtained solutions are graphically discussed to better visualize the wave phenomena connected to various symmetrical solitary wave solutions. The fractional Benney–Lin equation's dynamics and wave characteristics may be better understood through these graphical depictions, which makes it easier to analyze the model's behavior in detail.
Tracking Survivors With Long COVID: Method, Implementation, and Results of an Observational Study
Authors: Wu Horng‐Shiuann , Pathak Dola , Hall Mandy , Given Charles W. 
Published: January 2025

ABSTRACTWhile the coronavirus disease 2019 (COVID‐19) pandemic has declined, many survivors continue to suffer debilitating symptoms, such as fatigue, pain, and foggy thoughts. Sustained COVID‐19 symptoms, or Long COVID, challenge health care resources and economic recovery. This article describes the methodology, implementation, and results of an observational study investigating how time since diagnosis may affect lingering symptoms among the adult COVID‐19 population. The descriptive distribution and overall symptoms experience by individuals' characteristics were examined. Random samples from two patient cohorts (n = 147 in 2020−2021 and n = 137 in 2021−2022) were recruited from a COVID‐19 patient registry in mid‐Michigan. Samples were drawn from a pool of patients ≥ 3 months following their COVID‐19 diagnosis. Overall symptoms experience (number, severity, interference) was self‐reported using a comprehensive symptom inventory. The findings showed that 66% of the 2020−2021 cohort and 47% of the 2021−2022 cohort reported ≥ 1 lingering symptom with an average of 11.2 (±3.0) and 8.9 (±3.3) months, respectively, after COVID‐19 diagnosis. Females reported significantly more symptoms (p = 0.018), higher symptom severity (p = 0.008) and interference (p = 0.007) compared to males. Compared to patients admitted to emergency departments, outpatients reported significantly lower symptom severity (p = 0.020) and less symptom interference (p = 0.018). Our analyses showed that a moderate proportion (43%) of adults remained symptomatic nearly a year after COVID‐19 infection and time since diagnosis did not affect symptom experience in either cohort. Female sex and admission setting are important factors to consider for managing and studying Long COVID.
Maxillomandibular Advancement Safety and Effectiveness in Obstructive Sleep Apnea: Systematic Review and Meta‐Analysis
Authors: Walker Angelica , Kassir Mohamed F. , Sama Vineeth , Nguyen Shaun A. , Abdelwahab Mohamed 
Published: January 2025

AbstractObjectiveTo provide an updated evaluation of clinical effectiveness and sequelae of maxillomandibular advancement surgery in obstructive sleep apnea.Data SourcesPubMed, Scopus, CINAHL.Review MethodsIncluded studies described patients with obstructive sleep apnea that completed maxillomandibular advancement with any reported sequelae. Meta‐analysis of proportions, regressions, and single means with 95% confidence interval were calculated using random and fixed effects models.ResultsOf 380 unique abstracts reviewed, a total of 31 studies (n = 1597) were included in meta‐analysis. Maxillomandibular advancement patients showed significant improvements in apnea‐hypopnea index (AHI), respiratory disturbance index (RDI), SpO2 Nadir, Epworth sleepiness scale (ESS), and body‐mass index (BMI) by −41.87/h [−49.86 to −33.89], −46.24/h [−62.18 to −30.29], 6.29% [3.42 to 12.08], −8.69 [−11.54 to −5.83], and −0.74 kg/m2 [−1.35 to −0.12], respectively. Sequelae with the greatest incidence were early lower facial numbness (83.40%), late lower facial numbness at less and greater than 1 year follow‐up (66.51%, 32.73% respectively), and hardware removal (21.99%). There was a positive correlation between both preoperative BMI and length of hospital stay (r = 0.81, P = .052) and age and lower facial numbness (r = 0.42, P = .196). A negative correlation was found between Change in AHI and time to follow up (r = 0.75, P = .087). No major complications nor mortality were reported.ConclusionMaxillomandibular advancement has the highest success rate for obstructive sleep apnea among current surgical treatments, with most sequelae being transient. Early lower facial numbness should be highlighted preoperatively to ensure informed decision‐making. Further research should be geared towards reducing this risk.
Risk Factors for Suicidal Ideation and Attempt in Patients With Skull Base Tumors
Authors: Chung Tony , Edalati Shaun , Vasan Vikram , Iloreta Alfred Marc , Govindaraj Satish 
Published: January 2025

AbstractObjectivePatients with head and neck cancer experience suicide rates significantly higher than the general population. However, the relationship between skull base tumors (SBTs) and suicidal ideation and attempt (SIA) remains underexplored. This study aims to identify sociodemographic and clinical risk factors for SIA among patients with SBTs.MethodsA retrospective cohort study was conducted using the National Inpatient Sample (2016‐2019) to analyze 275,195 hospitalizations involving SBTs. Survey‐weighted methods were used to assess univariable and multivariable risk factors for SIA.ResultsAmong SBT patients, 2160 (0.78%) were diagnosed with SIA. Younger age (adjusted odds ratio [aOR]: 0.98; P < .001) and emergent admissions (aOR: 2.25; P < .001) were strongly associated with SIA. Socioeconomic difficulties were one of the most significant predictors (aOR: 7.57; P < .001). Depressive, bipolar, and adjustment disorders were the strongest mental health comorbidity predictors (aOR: 8.18, 7.24, 5.19, respectively; P < .001). Alcohol and cannabis use disorders also elevated SIA risk (aOR: 2.79, 2.29, respectively; P < .001). Protective factors included treatment in Western hospitals (aOR: 0.52; P < .001) and undergoing surgery (aOR: 0.29‐0.36; P < .001). Meningiomas were associated with lower SIA odds (aOR: 0.68; P = .013), while pituitary adenomas showed a significant association in univariable analysis.ConclusionYounger age, socioeconomic difficulties, mental health comorbidities, and substance use are key risk factors for SIA in SBT patients, while surgery and treatment in Western hospitals are protective. Regular suicidality screening and proactive mental health interventions are essential for improving outcomes in this vulnerable population.
Utilization of ChatGPT for Rhinology Patient Education: Limitations in a Surgical Sub‐Specialty
Authors: Huang Alice E. , Chang Michael T. , Khanwalkar Ashoke , Yan Carol H. , Phillips Katie M. , Yong Michael J. , Nayak Jayakar V. , Hwang Peter H. , Patel Zara M. 
Published: January 2025

AbstractObjectiveTo analyze the accuracy of ChatGPT‐generated responses to common rhinologic patient questions.MethodsTen common questions from rhinology patients were compiled by a panel of 4 rhinology fellowship‐trained surgeons based on clinical patient experience. This panel (Panel 1) developed consensus “expert” responses to each question. Questions were individually posed to ChatGPT (version 3.5) and its responses recorded. ChatGPT‐generated responses were individually graded by Panel 1 on a scale of 0 (incorrect) to 3 (correct and exceeding the quality of expert responses). A 2nd panel was given the consensus and ChatGPT responses to each question and asked to guess which response corresponded to which source. They then graded ChatGPT responses using the same criteria as Panel 1. Question‐specific and overall mean grades for ChatGPT responses, as well as interclass correlation coefficient (ICC) as a measure of interrater reliability, were calculated.ResultsThe overall mean grade for ChatGPT responses was 1.65/3. For 2 out of 10 questions, ChatGPT responses were equal to or better than expert responses. However, for 8 out of 10 questions, ChatGPT provided responses that were incorrect, false, or incomplete based on mean rater grades. Overall ICC was 0.526, indicating moderate reliability among raters of ChatGPT responses. Reviewers were able to discern ChatGPT from human responses with 97.5% accuracy.ConclusionThis preliminary study demonstrates overall near‐complete and variably accurate responses provided by ChatGPT to common rhinologic questions, demonstrating important limitations in nuanced subspecialty fields.