bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of ERAS Compliance on the Short-Term Outcomes for Distal Radius Surgery: A Single-Center Retrospective Study
Authors: Zha Mi Er A Li Mu Mu Er Ti , Sun Zhi Jian , Li Ting , Ti Re Zi Ya Ai Mai , Fu Gang , Yao Dong Chen , Yu Xiang 
Published: June 2023

Abstract
Background
Distal radius fractures (DRF) account for one in five bony injuries in both primary and secondary trauma care. Enhanced recovery after surgery (ERAS) has been adopted successfully for improvement and efficacy in numerous diseases; however, no study has demonstrated the different degrees of ERAS compliance on the short-term outcomes for distal radius surgery. We aimed to analyze whether different compliance degrees to the ERAS pathway are associated with improvement in patients with DRF.
Methods
We analyzed all consecutive patients with ERAS who underwent surgery for DRF at our department between May 2019 and October 2022 retrospectively. Their pre-, peri-, and post-operative compliance with the 22 elements of the ERAS program were assessed. We compared patient complications, the total length of hospitalization, the discharge time after surgery, hospital costs, times for return to preinjury level, times of the visual analogue scale (VAS) pain score > 3 points during hospitalization, disabilities of the arm, shoulder and hand (DASH) scores, and other parameters between low- (< 68.1%) and high-compliance (> 68.1%) groups. We performed multiple linear regression equations to assess the impact of ERAS compliance on the function level of the patients postoperatively (DASH scores).
Results
No significant differences were detected between the high- and low-compliance groups, with respect to the demographics, including the sex, age, body mass index (BMI), and comorbidity (P > 0.05). We observed significant differences between the high- and low-compliance groups in terms of the DASH score (32.25 ± 9.97 vs. 40.50 ± 15.65, p < 0.05) at 6 months postoperatively, the discharge time after surgery (2.45 ± 1.46 vs. 3.14 ± 1.50, p < 0.05), and times of VAS pain scores > 3 points during hospitalization (0.88, (0.44, 1.31), p < 0.05). Our study demonstrated a significant negative association between ERAS compliance and the function level of the patients postoperatively (DASH scores) when adjusted for the age, comorbidity, sex, and BMI.
Conclusion
This study can provide a realistic evaluation and comparison of the ERAS protocol among patients with DRF and eventually guide clinical decision making.
The ERAS protocol might improve the medical quality and efficacy with high function levels, less pain and time after surgery without increased complication rate and hospital cost.
Insights of the ultralow wear and low friction of carbon fiber reinforced PTFE in inert trace trace moisture environment
Authors: Johansson Pontus , Elo Robin , Naeini Vahid Fadaei , Marklund Pär , Björling Marcus , Shi Yijun 
Published: June 2023

Abstract
Ultralow wear rates and low friction have been observed for carbon fiber reinforced PTFE (CF/PTFE) when sliding against steel or cast iron in dry gas environments. Although the strong environmental sensitivity of this tribosystem is well known, the origin of the outstanding tribological performance in dry gas remains unanswered. Some researchers attribute the low friction and wear to the formation of carbon-rich surfaces in the absence of oxygen and moisture in the environment. However, low friction between carbon surfaces is generally dependent on moisture. In this paper, extensive analyzes are conducted on the tribofilms formed on the CF/PTFE surface and the steel counterface after sliding in a high-purity nitrogen environment. TEM analysis of a cross-section of the tribofilm on the steel surface reveals that the sliding surface consists mainly of iron (II) fluoride and not carbon, even though a significant amount of carbon was observed near the surface. XPS and TEM analysis further revealed that the tribofilm formed on the worn composite surface consisted of nanoparticle agglomerates, anchored to the PTFE matrix and to each other by carbon with turbostratic structure. Turbostratic carbon also formed an ultrathin and surface-oriented superficial layer on top of the agglomerates. Governing mechanisms of the low friction and wear of the CF/PTFE – steel tribosystem were investigated by complementary tribotests with pure graphite samples and MD simulations of the identified surfaces. These indicated that the low friction between the carbon and iron fluoride in the tribofilms is due to poor adhesion between the distinctly different surfaces.
DIS3 ribonuclease prevents the cytoplasmic accumulation of lncRNAs carrying non-canonical ORFs, which represent a source of cancer immunopeptides.
Authors: Foretek Dominika , Gabriel Marc , Hatin Isabelle , Jarroux Julien , Pinskaya Marina , Pepermans Elise , Boonen Kurt , Topno Rachel , Slaninova Vera , Serna Marina , Llorca Oscar , Baggerman Geert , Bertrand Edouard , West Steven , Namy Olivier , Morillon Antonin 
Published: June 2023

Abstract
Around 12% of multiple myeloma (MM) cases harbour mutations in DIS3, which encodes an RNA decay enzyme that controls the turnover of some long noncoding RNAs (lncRNAs). Although lncRNAs, by definition, do not encode proteins, some can be a source of (poly)peptides with biological importance, such as antigens. The extent and activities of these “coding” lncRNAs in MM are largely unknown. Here, we showed that DIS3 depletion results in the accumulation in the cytoplasm of 5162 DIS3-sensitive transcripts (DISTs) previously described as nuclear-localised. Around 14,5% of DISTs contain open reading frames (ORFs) and are bound by ribosomes, suggesting a possibility of translation. Transcriptomic analyses identified a subgroup of overexpressed and potentially translated DISTs in MM. Immunopeptidomic experiments revealed association of some DISTs’ derived peptides with major histocompatibility complex class I. Low expression of these transcripts in healthy tissues highlights DIST-ORFs as an unexplored source of potential tumour-specific antigens.
Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status
Authors: Ewald Victoria Muller , Trapp Nicholas T. , Sarrett McCall E. , Pace Benjamin D. , Wendt Linder , Richards Jenny , Gala Ilisa , Miller Jacob , Wessel Jan , Magnotta Vincent , Wemmie John , Boes Aaron , Parker Krystal 
Published: June 2023

Abstract
Background:
Widely reported by bipolar disorder (BD) patients, cognitive symptoms, including deficits in executive function, memory, attention, and timing are under-studied. Work suggests that individuals with BD show impairments in interval timing tasks, including supra-second, sub-second, and implicit motor timing compared to the neuronormative population. However, how time perception differs within individuals with BD based on BD sub-type (BDI vs II), mood, or antipsychotic medication-use has not been thoroughly investigated. The present work administered a supra-second interval timing task concurrent with electroencephalography (EEG) to patients with BD and a neuronormative comparison group. As this task is known to elicit frontal theta oscillations, signal from the frontal (Fz) lead was analyzed at rest and during the task.
Results:
Results suggest that individuals with BD show impairments in supra-second interval timing and reduced frontal theta power compared during the task to neuronormative controls. However, within BD sub-groups, neither time perception nor frontal theta differed in accordance with BD sub-type, mood, or antipsychotic medication use.
Conclusions:
his work suggests that BD sub-type, mood status or antipsychotic medication use does not alter timing profile or frontal theta activity. Together with previous work, these findings point to timing impairments in BD patients across a wide range of modalities and durations indicating that an altered ability to assess the passage of time may be a fundamental cognitive abnormality in BD.
Antecedent climate explains divergent, long-term restoration outcomes in the Western Great Plains, USA.
Authors: Mahood Adam , Barnard David , Macdonald Jacob , Green Tim , Erskine Robert 
Published: June 2023

Abstract

Converting croplands to grasslands can restore ecosystem functions and services. But there is uncertainty about why some restoration treatments succeed and others do not. Existing restoration strategies tailor species compositions of seed mixes according to mean conditions in hardiness zones. But individual years typically deviate from average climate norms such that restoration activities may be better informed by recent conditions than with climate averages in order to best direct management strategies. We monitored a field in eastern Colorado that was converted from wheat-fallow to native perennial grassland via seeding. The same seed mix was used to seed half the strips in 2013 (drier) and the other half in 2014 (wetter). The strips seeded in 2013 had only one native grass and shrub species from the seed mix establish, whereas in 2014 all native grasses established Higher soil moisture preceding seed application was positively associated with perennial grasses, while rhizomatous grasses, shrubs and introduced annuals were associated with other variables. We found evidence of facilitatory interactions between grasses and forbs, and antagonistic interactions between native perennial grasses and introduced annuals. These findings can assist land managers to improve upon current approaches by considering antecedent conditions during restoration planning.
Identification of Hazardous prone lakes using Remote Sensing and ANN applications in Western Himalaya
Authors: ray Aishwarya , Gaddam Vinay Kumar , Kusuma sundara kumar , Gaddam Hari Krishna 
Published: June 2023

Abstract
The Himalayan glaciers are observed to be declining for the past three to four decades, due to ongoing changes in climate. Among them, a few glaciers have favored the formation of (hazardous prone) lakes, which may burst and can cause severe damage to the downstream communities. Hence, these lakes need to be monitored continuously by identifying them. However, identification of these lakes is quite difficult because of limitations exist in a) accurate identification of pixels of lakes due to mixed pixels, b) existence of cloud cover c) classification error while applying automatic or semi-automatic approaches d) identification of movement of mass down slope due to coarse spatial resolution e) limited field measurements for validation etc. Also, Remote Sensing techniques alone may not be helpful for providing the solution for these types of catastrophic events. Therefore, advanced machine learning techniques such as Artificial Neural Network approach are preferred along with Remote sensing images for assessment of flood prone lakes. In this study, the glacial lakes are interpreted by using NDSI & NDWI approach using the latest satellite data of Landsat -8, and Sentinel -2a. A total of 355 glacial lakes are identified. However, due to above said limitations, manual interpretation is also carried out using high spatial resolution Google Earth pro images, and with this the initial count had increased from 355 to 655 lakes. Then, the lakes were classified into different categories namely Ice- dammed lakes, Moraine dammed lakes, Bed dammed lakes and other lakes. Further, the back propagation method of ANN algorithm is trained using the data from the spatial datasets and found that 18 lakes in the study region are more prone to hazards.
Pancreatitis and its relationship to diabetes
Authors: Almasri Yahya , Hammoud Taghreed 
Published: June 2023

Abstract
Background
In recent years, post-pancreatitis diabetes mellitus (PPDM), also known as type 3 diabetes mellitus, has received a great deal of attention from researchers. PPDM is one of the long-term sequelae of pancreatitis, and PPDM is now the second most common cause of new onset diabetes in adults after Type T2DM beyond type (T1DM), the aim of this study was to find out the proportion of patients who developed secondary diabetes mellitus as a complication of pancreatitis.
Methods
A cross-sectional study in Damascus Hospital, in the Department of Gastroenterology included 215 cases from 2017 to 2023.
Results
The percentage of males was 116 (54%), and the average age of the sample was approximately 45 years. Reef Dimashq had the largest percentage, reaching 108 (50.2%). More than half of the sample were non-alcoholics, and their percentage was 194 (90.2%), and non-smokers, and their percentage was 117 (54.4%). %), and the percentage of those who had complications of pancreatitis reached 114 (53%), and those who had symptoms of diabetes reached 59 (27.4%), and it was found that there is a real, statistically significant relationship between pancreatitis and the occurrence of diabetes as a complication of it, as the percentage of patients reached of those who had symptoms of diabetes 50 (23.3%).
The Labor Force Participation Rate in the Context of ESG Models at World Level
Authors: Leogrande Angelo , Costantiello Alberto 
Published: June 2023

Abstract
In this article we analyze the impact of Labor Force Partecipation Rate-LFPR in the context of the Environmental, Social and Governance-ESG model at world level. We use data from the ESG dataset of the World Bank for the period 2011-2020. We use Panel Data with Fixed Effects, Panel Data with Random Effects, Pooled OLS, Dynamic Panel. We find that the level of LFPR is positively associated among others to “Ratio of Female to Male Labor Force Participation Rate” and “Life Expectancy at Birth”, and negatively associated among others, to “Unemployment” and “Agricultural Land”. Furthermore, we have applied a clusterization with the k-Means algorithm optimized with the Silhouette coefficient, and we found the presence of three clusters. Finally, we confront eight different machine learning algorithms to predict the value of LFPR. We find that the best predictor is the Linear Regression. Linear Regression predicts an increase in LFPR equal to 0.42% on average for the analyzed countries.
Evaluation of awareness about corneal refractive surgery to correct refractive error in a sample of Syrian private university students
Authors: ghannam Shifaa , Salman Afraa 
Published: June 2023

Abstract
Background
The cornea is a transparent, avascular tissue that acts as a structural barrier and protects the eye from infections. Together with the tear film, it provides a suitable anterior refractive surface for the eye. The cornea contributes two-thirds of the refractive power of the eye. The study aims to evaluate knowledge and awareness about corneal refractive surgery among students of the Syrian Private University and its association with social and demographic characteristics.
Methods
This cross-sectional study was conducted in March 2023 on students of the Syrian Private University from all disciplines. Students were asked to participate voluntarily. A self-administered and filled out questionnaire in Arabic was used, distributed to students of the Syrian Private University, regarding awareness about refractive surgery. The questionnaire includes demographic information. It included questions about: gender, college, age, and academic year. Questions about awareness about refractive surgery. Questions about the source of information on awareness about refractive surgery for refractive errors.
Results
Out of 604 participants in the questionnaire, 37.9% were males and 62.1% were females, and most of their ages were from the age group of 18–22 with a rate of 89.2%. Most of the participants were from the Faculty of Human Medicine 44%, Pharmacy 33.8%, and Dentistry 20.2%, respectively. 24.5% of the students mentioned suffering from nearsightedness, 9.4% mentioned suffering from hyperopia, 1% suffering from astigmatism, while the majority (65.1%) stated that they did not complain of any refractive defect. Also, about 83% mentioned that they use medical glasses, and 17% that they do not use them. Only 4.2% of the students reported having had corneal refractive surgery, most of whom were satisfied with the outcome at 99%. The majority of the students were aware of the surgical procedures to correct refractive defects 86%, but nearly 61% were not ready to undergo the surgery for the following reasons: cost of the procedure 6.4%, fear of complications 30.6%, lack of information about the procedure 39.5%. The results showed a statistically significant relationship between prior knowledge about corneal refractive surgery and demographic factors.
Conclusion
The study recommends conducting other studies that examine knowledge about corneal refractive surgery in other samples such as employees, school students, and others, as the medical literature indicates that we still lack such studies, whether at the local level or at the Arab level. Conducting seminars and intensive educational programs to improve knowledge and awareness about the worst refraction and its various treatment methods, including corneal refractive surgery.
How Video Bloggers Involve Audience in Internet Communication: PewDiePie YouTube Channel
Authors: Olenev Stanislav , Cherkasov Danil 
Published: June 2023

The YouTube platform offers its users a number of ways to involve audience in Internet communication. This research covered twenty videos from Felix Kjellberg's PewDiePie channel. It involved observation and statistic processing, as well as quantitative and qualitative communication analysis based on special web services that provide access to analytical data for a particular YouTube channel or video. The videos were divided into functional and content elements that played different roles in attracting new viewers and encouraging them to interact with the blogger. The list of involvement techniques included: 1) maximal hashtag coverage of viewers' interests; 2) interaction with the audience in the comments; 3) active community life and demonstrative interest in the viewers; 4) a compelling video title and preview.
Methods to Improve the Stability of Nucleic Acid-Based Nanomaterials
Authors: Xie Xueping , Ma Wenjuan , Zhan Yuxi , Zhang Qifeng , Wang Chaowei , Zhu Huiyong 
Published: June 2023

Abstract:
Nucleic acid strands can be synthesized into various nucleic acid-based nanomaterials (NANs) through
strict base pairing. The self-assembled NANs are programmable, intelligent, biocompatible, non-immunogenic, and
non-cytotoxic. With the rapid development of nanotechnology, the application of NANs in the biomedical fields,
such as drug delivery and biological sensing, has attracted wide attention. However, the stability of NANs is often
affected by the cation concentrations, enzymatic degradation, and organic solvents. This susceptibility to degradation
is one of the most important factors that have restricted the application of NANs. NANs can be denatured or
degraded under conditions of low cation concentrations, enzymatic presence, and organic solvents. To deal with this
issue, a lot of methods have been attempted to improve the stability of NANs, including artificial nucleic acids,
modification with specific groups, encapsulation with protective structures, etc. In this review, we summarized the
relevant methods to have a deeper understanding of the stability of NANs.
Novel 1,3,4-trisubstituted Pyrazolopyrimidine Derivatives Show Potent Antiproliferative Activity in Mantle Cell Lymphoma
Authors: Ran Fansheng , Dong Lun , Liu Yang , Zhao Guisen 
Published: June 2023

Background:
Pyrazolopyrimidine scaffold is an important pharmacophore in drug discovery.
This pharmacophore has been reported to produce numerous biological activities, of which anticancer is
an important one. The development of novel pyrazolopyrimidine derivatives is of great importance for
antitumor drug research.

Objective:
Compound 6, a pyrazolopyrimidine derivative reported by our group, showed weak antiproliferative
activity with IC50 values of over 30 μM against mantle cell lymphoma (MCL) cell lines. In this
study, we will further perform the structural optimization of compound 6 to screen highly active pyrazolopyrimidine
derivatives.

Methods:
A novel series of 1,3,4-trisubstituted pyrazolopyrimidine derivatives were synthesized and their
structures were elucidated by 1H-NMR, 13C-NMR, and HRMS. The antiproliferative activities of target
compounds against MCL cell lines (Mino, Jeko-1, and Z138) were evaluated by the CellTiter-Glo luminescent
cell viability assay. The effect of representative compounds to induce apoptosis was evaluated by
Annexin V/Propidium Iodide (PI)-binding assay. Mitochondrial membrane potential and reactive oxygen
species (ROS) levels in 15c-treated Z138 cells were tested by JC-1 and DCFH-DA probes, respectively.

Results:
Most compounds demonstrated improved antiproliferative activity against MCL cell lines compared
to the lead compound 6, especially 15c, 15f, 15g, 15j, and 15o, with IC50 values at low micromolar
levels. In addition, compound 15c could induce apoptosis in a dose-dependent manner in Z138 cells
through reduction of mitochondrial membrane potential and enhancing reactive oxygen species production.

Conclusion:
The results showed that 1,3,4-trisubstituted pyrazolopyrimidine derivatives could be valuable
lead compounds for the further development of anti-lymphoma agents.
Chemistry and Biological Activity of Thieno[3,4-b]quinoline, Thieno[3,4-c]
quinolone, Thieno[3,2-g]quinoline and Thieno[2,3-g]quinoline Derivatives:
A Review (Part IX)
Authors: Abu-Hashem Ameen A. , Abdelgawad Ahmed A.M. , Gouda Moustafa A. 
Published: June 2023

Abstract:
Over the previous decades, thieno-quinoline derivatives have acquired great interest due to
their synthetic and biological applications. These reports have been disclosed on Thienoquinoline
synthesis such as thieno[3,4-b]quinoline; thieno[3,4-c]quinolone; thieno [3,2-g]quinoline; thieno[2,3-
g] quinoline; spiro-thieno[2,3-g]quinoline; benzo[b]thiophen-iso- quinoline derivatives, and therefore
in the existent review, we provided an inclusive update on the synthesis of thienoquinolines. Characterization
of the preparation methods and reactivity is categorized based on their types of reactions as
addition, alkylation, chlorination, acylation, oxidation, reduction, cyclization and cyclo-condensation.
Hence, this study will help the researchers to obtain knowledge from the last literature research to
conquer their resolve problems in designing new compounds and processes.