bluuebunny/crossref_metadata_2025_split huggingface dataset:
New distributed-topsis approach for multi-criteria decision-making problems in a big data context
Authors: Lamrini Loubna , Abounaima Mohammed Chaouki , Talibi Alaoui Mohammed 
Published: June 2023

AbstractNowadays, the online environment is extra information-rich and allows companies to offer and receive more and more options and opportunities in multiple areas. Thus, decision-makers have abundantly available alternatives to choose from the best one or rank from the most to the least preferred. However, in the multicriteria decision-making field, most tools support a limited number of alternatives with as narrow criteria as possible. Decision-makers are forced to apply a screening or filtering method to reduce the size of the problem, which will slow down the process and eliminate some potential alternatives from the rest of the decision-making process. Implementing MCDM methods in high-performance parallel and distributed computing environments becomes crucial to ensure the scalability of multicriteria decision-making solutions in Big Data contexts, where one can consider a vast number of alternatives, each being described on the basis of a number of criteria.In this context, we consider TOPSIS one of the most widely used MCDM methods. We present a parallel implementation of TOPSIS based on the MapReduce paradigm. This solution will reduce the response time of the decision-making process and facilitate the analysis of the robustness and sensitivity of the method in a high-dimension problem at a reasonable response time.Three multicriteria analysis problems were evaluated to show the proposed approach's computational efficiency and performance. All experiments are carried out within GCP's Dataproc, a service allowing the execution of Apache Hadoop and Spark tasks in Google Cloud. The results of the tests obtained are very significant and promising.
Finding the fragments: community-based epidemic surveillance in Sudan
Authors: Ibrahim Mona , Abdelmagid Nada , AbuKoura Rahaf , Khogali Alhadi , Osama Tasnime , Ahmed Aljaile , Alabdeen Israa Zain , Ahmed Salma A. E. , Dahab Maysoon 
Published: June 2023

AbstractSudan faces inter-sectional health risks posed by escalating violent conflict, natural hazards and epidemics. Epidemics are frequent and overlapping, particularly resurgent seasonal outbreaks of diseases such as malaria, cholera. To improve response, the Sudanese Ministry of Health manages multiple disease surveillance systems, however, these systems are fragmented, under resourced, and disconnected from epidemic response efforts. Inversely, civic and informal community-led systems have often organically led outbreak responses, despite having limited access to data and resources from formal outbreak detection and response systems. Leveraging a communal sense of moral obligation, such informal epidemic responses can play an important role in reaching affected populations. While effective, localised, and organised—they cannot currently access national surveillance data, or formal outbreak prevention and response technical and financial resources. This paper calls for urgent and coordinated recognition and support of community-led outbreak responses, to strengthen, diversify, and scale up epidemic surveillance for both national epidemic preparedness and regional health security.
Safety and efficacy of osimertinib plus bevacizumab as first-line treatment in EGFR-mutated NSCLC with brain metastasis instructed by dynamic monitoring circulating tumor DNA of paired cerebrospinal fluid and plasma.
Authors: Wei Fang , An Juan , Hua Yichun , Wang Kuanyu , Ding Xiaosheng , Zhou Lili , Zheng Xixi , Sun Shibin , Li Xiaoyan 
Published: June 2023

e21182 Background: The management of brain metastases in lung cancer was always a global challenge. Studies have shown that erlotinib combined with bevacizumab could bring progression-free survival benefit for NSCLC. Osimertinib is a third-generation EGFR tyrosine kinase inhibitor with higher CNS penetration. This study was to evaluate the safety and efficacy of osimertinib plus bevacizumab as the first-line treatment for patients with EGFR-positive NSCLC and brain metatases, and reveal the molecular characteristics of intracranial progression by matching plasma and CSF ctDNA. Methods: Patients with EGFR-positive NSCLC and brain metatases were treated with osimertinib (80mg, daily) plus bevacizumab (5mg/kg, every 4 week) as the first-line treatment. CSF and paird plasma ctDNA were collected before osimertinib and at the time of disease stable, intracranial progression and systematic progression, using the next-generation sequencing (NGS) to explore the dynamic changes between them. The primary end point was median CNS progression-free survival (PFS), CNS objective response rate (ORR). The second end point was to explore the molecular mechanism of CNS progression. Results: As the time of data cutoff (Jan 31, 2023), 15 patients were enrolled. 3 patients (20%) progressed in lung, 2 patients (13.3%) progressed in brain, and 1 patient (6.7%) progressed in leptomeningeal and bone, 2 of them still received oral osimertinib (80mg, daily). 9 patients (60%) were in partial or complete reponse and 8 of them continued to receive the original treatment. The median osimertinib exposure time was 16.8 months. The median bevacizumab exposure time was 9.1 months. The median CNS progression-free survival was 15.5 months (6.8 months to not reached). The CNS objective response rate was 93.33%. Six patients received gamma knife radiotherapy before Osimertinib, the median CNS progression-free survival was 14 months (6.8 months to not reached), the CNS objective response rate was 100%. After progression on Osimertinib, paired CSF and plasma ctDNA were analyzed and EGFR C797S, TP53, CDKN2A and etc could be found as resistanct mechanism. Adverse events of grade 3 or worse were observed in 1 patients (6.7%): severe ulcerative colitis, leading to the suspension of osimertinib. 2 patients (13.3%) stopped bevacizumab because of bleeding. Conclusions: This is a mid-term report with immature data. By the end of follow-up, we expected that osimertinib plus bevacizumab could better reduce the risk of intracranial progression and prolong the progression-free survival compared with osimertinib monotherapy. Clinical trial information: KY2021-155-02.
Diagnostic Efficacy of FNA-Tg in DTC Cervical LN Metastasis and its Impact Factors: A Large Retrospective Study
Authors: Liu Qianhui , Mao Li , Zhang Ziwei , Li Guixing , Song Haolan 
Published: June 2023

Abstract

Context
Thyroglobulin in needle washout fluid (FNA-Tg) has the advantage of compensating for the low sensitivity of cytological analysis (FNAC) in differentiated thyroid carcinoma (DTC) lymph node (LN) metastasis. However, studies of large data sets to support this view and identify the best cutoff of FNA-Tg are lacking.

Objective
Our study aimed to determine the best cutoff of FNA-Tg and explore the impact factors of FNA-Tg.

Method
A total of 1106 suspicious LNs from patients treated at West China Hospital from October 2019 to August 2021 were included. Parameters were compared between metastatic and benign LNs, and the best cutoff value of FNA-Tg was identified by ROC curves. The impact factors of FNA-Tg were analyzed.

Results
In the nonsurgery group, after correcting for the effect of age and short diameter of LN, FNA-Tg was the independent risk factor for cervical LN metastasis of DTC (odds ratio [OR]: 1.048; 95% CI, 1.032-1.065). In the surgery group, after correcting for the effects of serum thyrotropin, serum Tg, long diameter of LN, and short diameter of LN, FNA-Tg was the independent risk factor for cervical LN metastasis of DTC (OR: 1.019; 95% CI, 1.006-1.033). The best cutoff value of FNA-Tg was 25.17 μg/L, and the area under the receiver operating characteristic curve, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 0.944, 0.847, 0.978, 0.982, 0.819, and 0.902, respectively. FNA-Tg highly correlated with FNA-TgAb (P &lt; .01; Spearman correlation coefficient = 0.559), but FNA-TgAb positivity did not undermine the diagnostic efficacy of FNA-Tg for DTC LN metastasis.

Conclusion
The best cutoff value of FNA-Tg was 25.17 μg/L in diagnosing DTC cervical LN metastasis. FNA-Tg highly correlated with FNA-TgAb, but FNA-TgAb had no influence on the diagnostic efficacy of FNA-Tg.
Metreleptin Robustly Increases Resting-state Brain Connectivity in Treatment-naïve Female Patients With Lipodystrophy
Authors: Schlögl Haiko , Villringer Arno , Miehle Konstanze , Fasshauer Mathias , Stumvoll Michael , Mueller Karsten 
Published: June 2023

Abstract

Context
Research in lipodystrophy (LD) and its treatment with metreleptin has not only helped patients with LD but has opened new directions in investigating leptin's role in metabolism and the regulation of eating behavior. Previously, in a study with patients with LD undergoing metreleptin treatment using functional magnetic resonance imaging (MRI), we found significantly increased resting-state brain connectivity in 3 brain areas including the hypothalamus.

Objective
In this study, we aimed to reproduce our functional MRI findings in an independent sample and compare results to healthy participants.

Design
Measurements in 4 female patients with LD undergoing metreleptin treatment and 3 healthy untreated controls were performed at 4 different time points over 12 weeks. To identify treatment-related brain connectivity alterations, eigenvector centrality was computed from resting-state functional MRI data for each patient and each session. Thereafter, analysis aimed at detecting consistent brain connectivity changes over time across all patients.

Results
In parallel to metreleptin treatment of the patients with LD, we found a significant brain connectivity increase in the hypothalamus and bilaterally in posterior cingulate gyrus. Using a 3-factorial model, a significant interaction between group and time was found in the hypothalamus.

Conclusions
Investigating brain connectivity alterations with metreleptin treatment using an independent sample of patients with LD, we have reproduced an increase of brain connectivity in hedonic and homeostatic central nervous networks observed previously with metreleptin treatment. These results are an important contribution to ascertain brain leptin action and help build a foundation for further research of central nervous effects of this important metabolic hormone.
Staying Backward with the History of Camptown Trans Sex Work
Authors: Kim Sooyoung 
Published: June 2023

Abstract
Yangssaekshi (Western bride), Yanggongju (Western princess), and Yangggalbo (Western whore), also translated as “Camptown sex worker,” are the terms for South Korean women who provided sexual and service labor to the US soldiers during and after the Korean War. Yet buried here is a trans sex worker's history. What did it take for the contemporary South Korean trans community and trans studies globally to become detached from Camptown sex workers' knowledge and sociality? How has a certain universalized understanding of transness in trans studies alienated scholarship from Camptown sex workers' knowledge and blocked us South Koreans from positioning ourselves in the conventional trans genealogy? How has our omission preconditioned trans studies? Guided by decolonial trans scholarship, this essay thinks of the temporal narrativization of trans discourse, one that includes critical trans studies, that has formulated its own discursive territory through trans as a geopolitical marker of modernity.
Diphthongs
Authors: Avesani Tatiana 
Published: June 2023

Abstract
This contribution takes a look at diphthongs, which the author calls an oddly trans problem of language. Borrowed from their linguistic function, diphthongs may point to a trans methodology. On a page, diphthongs seem to be the crystallized image of a transition. Yet, as elements of a sentence or a word, they are not necessarily read as a unit. Depending on the context and the function that they serve at the moment they appear, diphthongs take on many different forms. This piece considers the ways in which a diphthong may be viewed as a metaphor for multiplicity within a single body and the implications it may have in the future of trans studies.
Materialist Girl
Authors: Peeples Alex 
Published: June 2023

Abstract
Beginning to reconcile the meaning of the contradiction at the heart of trans historiography requires two methodological insights. The first is a qualified recommitment to trans studies' partial global turn with a fervently anticolonial edge that recognizes the basic coloniality of trans as category. The second is a practice of historical political economy that can situate contemporary transness within longue durée colonial histories of class formation, social relation, and capital accumulation. Taken in tandem, these approaches demonstrate the need for scholarship that denaturalizes the category of trans and reinterrogates its economic and scholarly value if trans studies is to find a future that addresses its much-critiqued Eurocentrism and whiteness.
Trans Life and the Critique of Political Economy
Authors: Giardini Jo Aurelio 
Published: June 2023

Abstract
Thirty years have passed since Leslie Feinberg published hir pamphlet Transgender Liberation, a “Marxist view of when and why transgender oppression arose.” Since then, considerations of trans studies in relationship to the critique of political economy have developed unevenly, but a variety of recent scholarship enables routes for interrogating processes of gendering in relationship to labor, global economic development, and routinized immiseration. This short article surveys some of this work in order to mark how it might orient future trans scholarship. A renewed attention to Marxist critique can provide tools for charting the flourishing of trans life and the forces that work to dispossess it.
The Path of Friction
Authors: Zurn Perry 
Published: June 2023

Abstract
This article takes the twenty-five-year anniversary of C. Jacob Hale's “Suggested Rules for Non-transsexuals Writing about Transsexuals, Transsexuality, Transsexualism, and Trans___” (1997) to reflect on the nature of accountability to and within trans communities. Against the backdrop of interviews with Hale and his thought partners for the piece (e.g., Talia Bettcher, Jack Halberstam, and Naomi Scheman), Zurn draws out the historical context of the “Rules,” but also the affective, theoretical, and political frictions (and intimacies) that underlie them. Generated in the late 1990s scene of trans theory and activism, Hale's “Rules” were more than a corrective to cis-centric “positions” on trans people circulating at the time (esp. by Bernice Hausman); they were also a testament to friendship, as well as to the philosophical insights of María Lugones, Ludwig Wittgenstein, and Sandy Stone. Although written for non-trans writers, it was Hale's intention that the “Rules” also apply in trans-trans contexts. Indeed, in a world today where trans people are in fact leading trans studies, Hale's injunctions to humility in our approach to trans* peoples and to faith in the existing wisdom of trans life is prescient. So is his invitation to theorize on the rough ground of living and struggling together.
Introduction
Authors: Wang Ban 
Published: June 2023

Abstract
Taking issue with Anthropocene, deep ecology, and technological determinism, the introduction lays out this work's framework composed of the Marxist ecological notions of metabolic rift, the romantic legacy, and the Frankfurt School's critical ecology. Under capitalism, the metabolic rift manifests in the alienation of nature and of labor. The system of accumulation and profit, bent on the domination of nature and labor, is the major source of ecological crises. The introduction addresses alternative modes of production where ecological bonds between humans and nature are maintained through embodied and ecological labor. Through technology and associated labor, humans can regulate and control metabolism between ourselves and nature and among ourselves, changing environments while changing ourselves.
Chapter Two: Lu Xun's Mytho-ecological Refutation of Technocrats
Authors: Wang Ban 
Published: June 2023

Abstract
Primarily thought of as a critic of Chinese tradition, Lu Xun is less understood as a critic of technoscientific rationality. Walter Benjamin invoked the utopian reconciliation of humans and nature from premodern culture in critiques of modernity. In the same vein, Lu Xun recovered images of the ancient world where rural folks lived in intimacy with nature, worshiped supernatural beings, and observed time-honored rituals. Linking the myth of progress and technology to a chorus of “malevolent voices” by a “hypocrite gentry,” Lu Xun urged that we should rid of ourselves of this hypocrite gentry and retain mytho-ecological beliefs. Examining Lu Xun's stories from Old Tales Retold, this chapter explores the Chinese writer's recovery of the mythical and ecological images from the past in his critique of technocratic modernity. Confronted with the myth of progress, technological fetishism, and the rise of a technocratic elite, Lu Xun sought to uncover and redeem primordial images from archaic traditions.
Chapter Four: We Are the Dragon King
Authors: Wang Ban 
Published: June 2023

Abstract
Rather than a war against nature, a genuine production is premised on the humanization of nature by producing use values while changing human inner nature. Socialist production strives to achieve an ecologically sound economy whereby labor on nature is in sync with the realization of human inner potentials. In the two-part film Young People in Our Village, young people of a small village modify the natural environment, channel water resources, and solve the perennial scourge of water shortage. Rather than being at the mercy of drought, the young villagers launch into a water project. Instead of a conquest of nature, their enterprise represents a necessary life-affirming and life-saving production to modify nature by exercising their sovereignty, intelligence, technoscientific knowledge, and productive skills.
Chapter Seven: Art and Labor in Han Song's Regenerated Bricks
Authors: Wang Ban 
Published: June 2023

Abstract
The romantic and ecological legacy of Homo faber sheds light on Han Song's Regenerated Bricks. In that novella the victims of the 2008 Wenchuan earthquake, guided by an architect, produce bricks by using debris, straw, and corpses. Regenerating lives and hopes of the victims and furnishing building material, the brick testifies to a practice that combines labor and art and a biological rebirth associated with the fertility of the earth. The brick is not only useful but also aesthetically resonant. Working closely with the workers in the fields and workshops rather than from urban offices, the elite architect transforms into a “barefoot architect.” On the other hand, the culture market, neoliberal ideology, and digital media quickly turn the brick into a simulacrum and a consumer icon, alienating the brick and the creators from their vital connection with nature and the earth.
Chapter Ten: Critical Ecotopia in Hao Jingfang's Vagabonds
Authors: Wang Ban 
Published: June 2023

Abstract
“Ecotopia” describes the social ecology of a world whose socioeconomic institutions are premised on the utopian dream of the reconciliation of the human and nature. The Mars Republic of Hao Jingfang's novel Vagabonds is built through advanced technologies that allow humans to terraform the planet and adapt to the arid environment along with the construction of an ecologically sound social and economic system. But the visions of ecotopia are challenged and interrogated by cultural and political clashes and differences between environmentally degraded Earth and utopian Mars. Through planetary travels, exchange, and conflict between the two planets, Vagabonds tells a story of mutual shocks and critiques among interplanetary travelers, capitalists, artists, and Martian youth. In their personal growth, the Martian youths question and explore their identity, belonging, and the balance between society and nature.
Epilogue
Authors: Wang Ban 
Published: June 2023

Abstract
Ecocriticism offers a broader horizon than the concept of world literature. Instead of treating culturally bonded beings and political events of a zeitgeist, ecocriticism sees human history and lifeworlds as only one trajectory among myriad evolutions of species and the earth. The Anthropocene, with its focus on post-natural universals such as “man as geological agent,” obscures the fatal contradictions within capitalism, which has inherent eco-destructive tendencies. As a mode of production aimed at robbing the worker and robbing the soil, capitalism is destined to pursue capital accumulation, profit, and growth to the destruction of ecospheres and human communities. Alternatively, eco-socialism sees humans as an organism integral to nature but believes that human production must protect human lives and community from nature's blind forces in order to survive and to thrive. The utopian dream resonates with the myths of the goddess and ideas of substantial rationality imbued with aesthetic aura and ecological bonds with nature and the earth. This present work seeks to recover the utopian dream of the reconciliation of humans and nature.
The Pressure Is Rising: Evaluation and Treatment of Chronic Exertional Compartment Syndrome
Authors: Malik G. Ross , Vyas Krina A. 
Published: June 2023

AbstractChronic exertional compartment syndrome is a condition that typically affects athletic/active individuals. Chronic exertional compartment syndrome predominantly affects the lower leg; however, there are cases involving the hand, forearm, foot, and thigh. The signs and symptoms of chronic exertional compartment syndrome are severe pain, tightness, cramping, muscle weakness, and paresthesias during participation in exercise. Dynamic intramuscular compartmental pressure (preexertion and postexertion) is the standard diagnostic test. Although other imaging modalities, such as radiography, ultrasound, and magnetic resonance imaging are typically incorporated to rule out other pathologies. In addition, these modalities are being utilized to limit invasiveness of the diagnostic experience. Initial care commonly involves conservative treatment, such as physical therapy, modifications of patient's exercise technique, foot orthoses, and various procedures over a period of 3 to 6 months. Recalcitrant cases may be referred for surgical intervention (fasciotomy), which has inconclusive head-to-head data with conservative management with regard to return to prior sport and specific activity level.