bluuebunny/crossref_metadata_2025_split huggingface dataset:
Membrane‐based therapeutic plasma exchange: Proposed techniques for preventing filter failure
Authors: Elali Ibrahim , Phachu Deep , Coombs Nick , Shah Mamta , Dean Jordan , Haider Lalarukh , Wang Yanlin , Kaplan Andre A 
Published: June 2023

AbstractBackground and ObjectivesTherapeutic plasma exchange (TPE) is commonly performed using membrane‐based TPE (mTPE) and is prone to filter failure.Design, Setting, Participants, & MeasurementsWe report on 46 patients, with a total of 321 mTPE treatments using the NxStage machine. This was a retrospective study with an aim to evaluate the effect of heparin, pre‐filter saline dilution and the impact of total plasma volume exchanged (< 3 L vs. ≥3 L) on the rate of filter failure. Primary outcome was the overall rate of filter failure. Secondary outcomes included factors that may have indirectly influenced the rate of filter failure, including hematocrit, platelet count, replacement fluid (Fresh Frozen Plasma vs. albumin), and access type.ResultsWe found that treatments that received both pre‐filter heparin and saline had a statistically significant decrease in filter failure rate as compared to those that received neither (28.6% vs. 5.3%, P = .001), and compared to the treatments that received pre‐filter heparin alone (14.2% vs. 5.3%, P = .015). In treatments that received both pre‐filter heparin and saline predilution, we noted a significantly higher filter failure rate when the plasma volume exchanged was ≥3 L as compared to those that had <3 L exchanged (12.2% vs. 0.9%, P = .001).ConclusionsRate of filter failure in mTPE can be reduced by implementing several therapeutic interventions including pre‐filter heparin and pre‐filter saline solution. These interventions were not associated with any clinically significant adverse events. Despite the above‐mentioned interventions, large plasma volume exchanges of ≥3 L can negatively impact filter life.
Enhanced myometrial vascularity and AVM: A review on diagnosis and management
Authors: Moradi Behnaz , Banihashemian Masoumeh , Sadighi Nahid , Shirali Elham , Saleem Shady Abdelsattar , Najafi Ehsan 
Published: June 2023

AbstractUterine Arteriovenous malformations (AVM) are vascular disorders characterized by complex high‐flow tangles of abnormal vessels connecting arteries and veins with bypassing capillaries. Recently, the terminology applied to describe uterine AVMs has been modified. Most AVMs are acquired. The term enhanced myometrial vascularity (EMV) is used to describe any condition in which any uterine pathology may lead to increased myometrial vascularity regardless of the absence or presence of residual tissue of gestation.
Links between gender norms and the intergenerational transmission of health information in parents carrying BRCA1/2 pathogenic variants
Authors: Gauna F. , Carof S. , Mouret‐Fourme E. , Coupier I. , Mari V. , Moretta‐Serra J. , Mancini J. , Noguès C. , Bouhnik A. D. 
Published: June 2023

AbstractUnderstanding how gender norms affect parents' communication of genetic and cancer risk information to their children can enable healthcare professionals to better facilitate cascade genetic testing. We conducted a qualitative study with semi‐structured interviews to determine social factors associated with parents carrying the BRCA1/2 pathogenic variants who communicated cancer prevention practices to their children. Thirty adult carriers (23 women, 7 men) participated in the interviews. All had at least one child aged over 8 years old. Interview topics included their discovery of the variants, their relationship to their body and to the risk of cancer, as well as disclosure to and subsequent communication with their children after testing positive for BRCA1/2. The interviews were analyzed qualitatively, and the major themes identified were identified and compared. We described the roles played by the BRCA1/2 carriers and their partners in communicating cancer prevention practices to their children, from how they managed their own risk of cancer after testing positive, to how they disclosed the risks linked to these pathogenic variants to their children. We also described their involvement in the process of their children going for professional genetic consultation. Gender norms lead women to be more attentive than men to their own health and that of their loved ones. In the context of the transmission of genetic information to children, gender differences in behavior are reinforced by perceptions of the risks of BRCA1/2 variants and women's related health management practices. Cancer prevention is shaped by complex links between gender norms and health management practices.
Advances in management of primary myelofibrosis and polycythaemia vera: Implications in clinical practice
Authors: Amé Shanti , Barraco Fiorenza , Ianotto Jean‐Christophe , Jourdan Eric , Rey Jérôme , Viallard Jean‐François , Wémeau Mathieu , Kiladjian Jean‐Jacques 
Published: June 2023

AbstractPrimary myelofibrosis (PMF) and polycythaemia vera (PV) are rare BCR‐ABL1‐negative myeloproliferative neoplasms, associated with an increased risk of thrombosis, haemorrhagic complications and progression to fibrosis or leukaemia or fibrosis for PV. Both diseases are characterised by biological and clinical heterogeneity, leading to great variability in their management in routine clinical practice. In this review, we present an updated overview of the diagnosis, prognosis and treatment of PMF and PV, and we discuss how our multidisciplinary expert group based across France translates this evidence‐based knowledge into routine clinical practice.
Climatological characteristics of the monsoon breaks during the southwest monsoon season of the Philippines
Authors: Olaguera Lyndon Mark P. , Manalo John A. , Matsumoto Jun 
Published: June 2023

AbstractThis study investigates the climatological characteristics of the monsoon breaks during the southwest monsoon season (June–September) of the Philippines from 1979 to 2020. The monsoon break is defined as a period when the average rainfall across the eight western coast stations of the Philippines decreases below 5 mm·day−1 for at least three consecutive days. About 208 monsoon break events were identified, with 131 short‐ (3–4 days; 63% of the total monsoon break events), 71 medium‐ (5–9 days; 34%) and 6 long‐duration (≥10 days; 3%) monsoon break events. The short‐ and medium‐duration monsoon breaks were found to be more frequent during June and less frequent during August. Lag composite analyses of the time series of rainfall, low level zonal wind (UWND850hPa), vertically integrated moisture flux convergence (VIMFC) and mid‐tropospheric geopotential height (HGT500hPa) relative to the starting date of the monsoon break events show that the monsoon break is characterized by decrease in rainfall, weakening of westerly winds, increase in HGT500hPa and suppression of VIMFC over Luzon Island. Further analyses of the large‐scale circulation features show the appearance of an anticyclonic circulation over Luzon Island that suppresses the rainfall in the region and westward extension of the western North Pacific Subtropical High (WNPSH). The occurrence of the monsoon break events appears to be modulated by the 30–60‐day mode of the boreal summer intraseasonal oscillation (BSISO). About 39%, 55% and 82% of the short‐, medium‐ and long‐duration monsoon break events occur between Phases 1 and 4 during significant suppressed phases of the BSISO (i.e., amplitude >1), respectively. Convective activities and tropical cyclone activities are generally suppressed in these phases. The suppression of convective activities near the Philippines may facilitate the westward expansion of WNPSH, which further suppresses the rainfall and weaken the southwest monsoon.
Subgingival scaling and root planing during minimally invasive periodontal surgery: A randomized controlled split‐mouth trial
Authors: Dunegan Kara A. , Deas David E. , Powell Charles A. , Ruparel Nikita B. , Kotsakis Georgios A. , Mealey Brian L. 
Published: June 2023

AbstractBackgroundThe purpose of this randomized, controlled split‐mouth study was to evaluate a videoscope as a visual adjunct to scaling and root planing when utilized in combination with minimally invasive surgery.MethodsTwenty‐five pairs (89 interproximal surfaces) of periodontally hopeless teeth planned for extraction were scaled and root planed with minimal surgical access using surgical loupes (control) or adjunctive use of a videoscope (test). Teeth were extracted with minimal trauma, stained with methylene blue, and photographed with a digital microscope for analysis. The primary outcome of residual calculus was calculated as a percentage of the total interproximal area of interest. Secondary outcomes included treatment time, as well as residual calculus according to probing depth, tooth location, and treatment date. Data were analyzed using Student's paired t‐tests, two‐way analyses of variance, and Spearman's correlation tests.ResultsResidual calculus area was 2.61% on control and 2.71% on test surfaces with no significant difference between groups. Subgroup analysis showed no difference in residual calculus between groups at moderate or deep sites. Treatment time per surface was significantly longer in the test group compared to the control group. Treatment order, tooth location, and operator experience did not significantly affect the primary outcome.ConclusionsThough the videoscope provided excellent visual access, it did not improve the efficacy of root planing for flat interproximal surfaces during minimally invasive periodontal surgery. Small amounts of calculus remain after instrumentation even with minimal surgical access and when root surfaces appear visually clean and tactilely smooth.
Raman spectroscopy, assisted by X‐ray fluorescence and laser‐induced breakdown spectroscopy, to characterise original and altered mineral phases in the NWA 2975 Martian shergottite
Authors: Población Iratxe , Torre‐Fdez Imanol , Aramendia Julene , López‐Reyes Guillermo , Cabalín Luisa M. , Madariaga Juan Manuel , Rull Fernando , Laserna Javier J. , Carrizo Daniel , Martínez‐Frías Jesús , Belenguer Tomás , Taravillo Mercedes , Dell'Aglio Marcella , De Giacomo Alessandro , Huidobro Jennifer , Manrique Jose Antonio , Delgado Tomás , Arana Gorka , Castro Kepa , Veneranda Marco , Sanz‐Arranz J. A. , Fortes F. Javier , García‐Gómez Laura ,   the SIGUE‐Mars team
Published: June 2023

AbstractA fragment of the NWA 2975 Martian meteorite, an enriched basaltic shergottite, was analysed to complete its geochemical characterisation performed 10 years ago. By this means, the feasibility of the employed techniques in a combined way for present and future space exploration missions can be tested. For this aim, Raman spectroscopy was used supported by micro energy dispersive X‐ray fluorescence (μ‐EDXRF) and laser‐induced breakdown spectroscopy (LIBS) for an accurate interpretation of molecular and elemental results. Raman spectroscopy results from two setups, InVia from Renishaw and RLS Simulator, were compared. The major minerals detected by Raman spectroscopy were pyroxenes (mainly augite, pigeonite and enstatite) and plagioclases (mainly shocked maskelynite). Raman spectroscopy allowed defining different metal compositions for these main minerals based on the secondary Raman spectroscopy bands in the 200–500 cm−1 region. In addition, other minerals were found such as merrillite, as well as pyrrhotite and apatite, in several veins and cracks of the meteorite, in agreement with the initial report by the Meteoritical Bulletin. Moreover, it should be highlighted that coesite was found for the very first time in this meteorite.
Preparation, structure characterization, and stability analysis of peptide–calcium complex derived from porcine nasal cartilage type II collagen
Authors: Cui Pengbo , Li Mengyu , Shao Tianlun , Yu Mingxiao , Zhao Weixue , Song Yanzhuo , Ding Yuting , Liu Jianhua 
Published: June 2023

AbstractBACKGROUNDPorcine nasal cartilage type II collagen‐derived peptides (PNCPs) may be complexed with calcium to provide a highly bioavailable, low‐cost, and effective calcium food supplement. However, the calcium‐binding characteristics of PNCPs have not yet been investigated. In the present study, calcium‐binding peptides were derived from porcine nasal cartilage type II collagen and the resulting PNCPs‐Ca complex was characterized.RESULTSThe study reveals that the calcium‐binding capacity of PNCPs is closely related to enzymatic hydrolysis conditions. The highest calcium‐binding capacity of PNCPs was observed at a hydrolysis time of 4 h, temperature of 40 °C, enzyme dosage of 1%, and solid‐to‐liquid ratio of 1:10. Scanning electron microscopy and energy dispersive X‐ray spectroscopy revealed that the PNCPs had a pronounced capacity for calcium binding, with the PNCPs‐Ca complex exhibiting a clustered structure consisting of aggregated spherical particles. Fourier‐transform infrared spectroscopy, fluorescence spectroscopy, X‐ray diffraction, dynamic light scattering, amino acid composition, and molecular weight distribution analyses all indicated that the PNCPs and calcium complexed via the carboxyl oxygen and amino nitrogen atoms, leading to the formation of a β‐sheet structure during the chelation process. In addition, the stability of the PNCPs‐Ca complex was maintained over a range of pH values consistent with those found in the human gastrointestinal tract, facilitating calcium absorption.CONCLUSIONThese research findings suggest the feasibility of converting by‐products from livestock processing into calcium‐binding peptides, providing a scientific basis for the development of novel calcium supplements and the potential reduction of resource waste. © 2023 Society of Chemical Industry.
Rumination about the Russo‐Ukrainian War and its related factors among individuals in Poland and Ukraine
Authors: Li Dian‐Jeng , Chudzicka‐Czupała Agata , Paliga Mateusz , Hapon Nadiya , Karamushka Liudmyla , Żywiołek‐Szeja Marta , McIntyre Roger S. , Chiang Soon‐Kiat , Chen Yi‐Lung , Yen Cheng‐Fang , Man Roger Ho Chun 
Published: June 2023

AbstractThe present study aimed to investigate the factors associated with the level of rumination about the war among people living in Poland and Ukraine. This cross‐sectional study recruited internet users from advertisements on social media. Levels of rumination, Depression, Anxiety and Stress Scale (DASS), Impact of Event Scale‐Revised (IES‐R), time spent on news of the war, and related demographic variables were collected. The reliability and construct validity of rumination were estimated. Potential factors associated with the level of rumination were identified using univariate linear regression analysis, and further entered into a stepwise multivariate linear regression model to identify independent factors. Due to the non‐normality of distribution, multivariate linear regression with 5000 bootstrap samples was used to verify the results. A total of 1438 participants were included in the analysis, of whom 1053 lived in Poland and 385 lived in Ukraine. The questionnaires on rumination were verified to have satisfactory reliability and validity. After analysis with stepwise and bootstrap regression, older age, female gender, higher DASS and IES‐R scores, and longer time spent on news of the war were significantly associated with higher levels of rumination for both people living in Poland and Ukraine. Lower self‐rated health status, history of chronic medical illness and coronavirus disease 2019 infection were also positively associated with rumination for people living in Poland. We identified several factors associated with the level of rumination about the Russo‐Ukrainian War. Further investigations are warranted to understand how rumination affects individuals’ lives during crises such as war.
Linear versus Turbulent Airflow Tracheostomy Heat and Moisture Exchangers: A Crossover Study
Authors: Shikani Alan H. , Rohayem Ziad , D'Adamo Christopher R. , Miller Andrew C. 
Published: June 2023

ObjectiveThis study aimed to evaluate the impact of two tracheostomy heat and moisture exchangers (HMEs), namely the Shikani Oxygen HME™ (S‐O2HME, ball type, turbulent airflow) and Mallinckrodt Tracheolife II DAR HME (M‐O2HME; flapper type, linear airflow) on tracheobronchial mucosal health, oxygenation, humidification, and patient preference.MethodsA randomized cross‐over study was conducted with HME‐naïve long‐term tracheostomy subjects at two academic medical centers. Bronchoscopy assessments of mucosal health were performed at baseline and day 5 of HME application, along with oxygen saturation (SpO2) and breathed air humidity at four oxygen flow rates (1, 2, 3, and 5 lpm). Patient preference was assessed on study conclusion.ResultsBoth HMEs were associated with improved mucosal inflammation and decreased mucus production (p < 0.0002), with greater improvements in the S‐O2HME group (p < 0.007). Both HMEs improved humidity concentration at each oxygen flow rate (p < 0.0001), without significant differences between groups. SpO2 was greater for the S‐O2HME versus the M‐O2HME across all measured oxygen flow rates (p = 0.003). At low oxygen flow rates (1 or 2 lpm), the SpO2 in the S‐O2HME group was similar to that of the M‐O2HME at higher oxygen flow rates (3 or 5 lpm; p = 0.6). Ninety percent of subjects preferred the S‐O2HME.ConclusionTracheostomy HME uses correlated with improved indicators of tracheobronchial mucosal health, humidity, and oxygenation. The S‐O2HME outperformed the M‐O2HME with respect to tracheobronchial inflammation, SpO2, and patient preference. Regular HME use by tracheostomy patients is recommended to optimize pulmonary health. Newer ball‐type speaking valve technology additionally allows concomitant HME and speaking valve application.Level of Evidence2 Laryngoscope, 133:3422–3428, 2023
Solar farm investment game model: A data‐driven case in Florida
Authors: Ma Junhai , Xu Tiantong 
Published: June 2023

AbstractThe most effective approach to subsidizing power producers in order to bolster the penetration of renewable energy is continuously debated. To address this issue, this paper undertakes an in‐depth investigation into a solar farm investment problem, aiming at capturing the common interests and frictions among the government, the solar system developer, and the utility. In this paper, both static and dynamic game models are proposed with the consideration of the uncertainty of solar power generation. Before investing in a solar farm project, a potential solar farm investor takes into account of subsidy rate regulation for utilities enacted by the government, the panel price announced by the solar developer. In this study, we identified two thresholds of solar panel cost, which provide valuable insights for government policymakers when formulating an appropriate subsidy rate for the solar energy industry. Besides, a optimal policy for each stakeholder has been exposed. The finding from the dynamic model discloses the profound influence of various behaviors on the long‐term profitability of each stakeholder. Finally, based on the real‐world solar power data in Orlando, a case study is presented to expose a more tangible prospect for industrial application.
Huntington's Disease with Small CAG Repeat Expansions
Authors: Heinzmann Anna , Sayah Sabrina , Lejeune François‐Xavier , Hahn Valérie , Teichmann Marc , Monin Marie‐Lorraine , Marchionni Enrica , Gérard Fleur , Charles Perrine , Pariente Jérémie , Durr Alexandra 
Published: June 2023

AbstractBackgroundCarriers of small cytosine‐adenine‐guanine (CAG) repeats below 39 in the HTT gene are traditionally associated with milder Huntington's disease, but their clinical profile has not been extensively studied.ObjectiveTo study the phenotype of CAG36‐38 repeat carriers.MethodsWe included 35 patients and premanifest carriers of CAG36‐38 repeats. We compared clinical and neuropsychological profiles of 11 CAG36‐38 patients with 11 matched CAG40‐42 patients. In addition, we analyzed 243 CAG36‐38 individuals from the ENROLL study to complete the phenotype description.ResultsGlobal cognitive efficiency and performance in different cognitive subdomains were similar in small CAG36‐38 and typically CAG40‐42 expanded individuals. Chorea as the first symptom was significantly less frequent for CAG36‐38 patients (P = 0.04) despite similar total motor scores at first visit. Total motor score at last visit was significantly lower in CAG36‐38 carriers (P = 0.003). The similar cognitive and different motor profile of CAG36‐38 (n = 243) and CAG40‐42 (n = 4675) carriers was confirmed in the ENROLL database. Additionally, clinicians were significantly less confident in diagnosing Huntington's disease (P = 2.4e−8) and diagnosis happened significantly later in CAG36‐38 (P = 2.2e−6) despite a similar age at symptom onset (P = 0.29).ConclusionsWe showed that small CAG36‐38 expansion carriers had a similar cognitive profile to those with the more common CAG40‐42 expansions. These individuals may evade molecular diagnosis because of the absence of chorea rather than because of a low penetrance of symptoms. This finding should encourage neurologists to consider Huntington's disease in cognitively impaired elderly patients without typical chorea and anticipate consequences for genetic counseling in their offspring. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
StruNet: Perceptual and low‐rank regularized transformer for medical image denoising
Authors: Ma Yuhui , Yan Qifeng , Liu Yonghuai , Liu Jiang , Zhang Jiong , Zhao Yitian 
Published: June 2023

AbstractBackgroundVarious types of noise artifacts inevitably exist in some medical imaging modalities due to limitations of imaging techniques, which impair either clinical diagnosis or subsequent analysis. Recently, deep learning approaches have been rapidly developed and applied on medical images for noise removal or image quality enhancement. Nevertheless, due to complexity and diversity of noise distribution representations in different medical imaging modalities, most of the existing deep learning frameworks are incapable to flexibly remove noise artifacts while retaining detailed information. As a result, it remains challenging to design an effective and unified medical image denoising method that will work across a variety of noise artifacts for different imaging modalities without requiring specialized knowledge in performing the task.PurposeIn this paper, we propose a novel encoder‐decoder architecture called Swin transformer‐based residual u‐shape Network (StruNet), for medical image denoising.MethodsOur StruNet adopts a well‐designed block as the backbone of the encoder‐decoder architecture, which integrates Swin Transformer modules with residual block in parallel connection. Swin Transformer modules could effectively learn hierarchical representations of noise artifacts via self‐attention mechanism in non‐overlapping shifted windows and cross‐window connection, while residual block is advantageous to compensate loss of detailed information via shortcut connection. Furthermore, perceptual loss and low‐rank regularization are incorporated into loss function respectively in order to constrain the denoising results on feature‐level consistency and low‐rank characteristics.ResultsTo evaluate the performance of the proposed method, we have conducted experiments on three medical imaging modalities including computed tomography (CT), optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA).ConclusionsThe results demonstrate that the proposed architecture yields a promising performance of suppressing multiform noise artifacts existing in different imaging modalities.