bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antecedents of consumers' online apparel purchase intention through Virtual Try On technology: A moderated moderated‐mediation model
Authors: Chidambaram Vijayabanu , Rana Nripendra P. , Parayitam Satyanarayana 
Published: March 2023

AbstractThe study aims to empirically examine the consumers' online apparel purchasing behavior using the constructs from the technology acceptance model (UTAUT). The complex interrelationships between perceived usefulness, perceived risk, perceived enjoyment, and virtual try‐on (VTO) technology were explored using a moderated moderated‐mediation model. Most importantly, this research focuses on how VTO, one of the frequently used disruptive technologies, influences consumer behavior. Using a structured survey instrument, the data was collected from 288 millennial respondents and has been analyzed using Hayes's PROCESS macros. The results reveal that attitude towards VTO mediated the relationship between perceived usefulness and behavioral intention of customers to engage in online shopping. Perceived risk (first moderator) negatively moderated the relationship between perceived usefulness and attitude towards VTO, and perceived enjoyment (second moderator) has positively moderated the relationship between perceived usefulness and perceived risk and behavioral intention mediated through attitude towards VTO. The theoretical and practical implications were also discussed.
C‐Dimethylated Flavones as Possible Potential Anti‐Tubercular and Anticancer Agents.
Authors: Bollikolla Hari Babu , Anandam Rambabu , Chinnam Sampath , Varala Ravi , Khandapu Bala Murali Krishna , Kapavarapu Ravikumar , Syed Khasim Sharif , Dubasi Narasimhaswamy , Syed Mastan Ali 
Published: March 2023

AbstractThe present investigation describes an intramolecular Oxa‐Michael addition of penta‐substituted phenols to the enone of the tether in the presence of iodine as the oxidizing agent. TenC‐Dimethylated flavones with moderate to good yields (10a–j, 60–89 %) were isolated by heating the correspondingC‐dimethylated chalcones using iodine in DMSO. Using the Microplate Alamar Blue test (MABA) technique, the drugs′ quantitative drug susceptibility against the H37Rv strain of replicating Mycobacterium TB was determined. The sensitivity of two of the developed compounds (10e,10h) was up to 6.25 g/mL. The human lung adenocarcinoma cell lines (A549) were used in the anticancer study, which was carried out using the MTT cell proliferation assay. In A549 cell lines, four flavones demonstrated anticancer activity with IC50values between 39 and 48 μM. TheC‐dimethylated flavones,10b(3,4‐dimethoxy),10c(2,3,4‐trimethoxy),10e(p‐fluoro) and10g (N‐methyl indole) substitutions on ring ‘B’ showed good anticancer activity with IC50values 39.17, 39.21, 48.43 and 43.48 μM, respectively. The compounds10b,10c,10d,10e, and10ihad improved binding and interaction profiles among all the compounds examined during the currentIn Silicoresearch, as shown by the docking simulations against two targets EGFR and MTB MurI.
Continuous local intravenous heparin infusion after re‐exploration for venous congestion in free‐flap breast reconstruction: A case series
Authors: Kubo Kazuyuki , Kirita Miho , Hamahata Atsumori , Sakurai Hiroyuki 
Published: March 2023

AbstractWe demonstrated local intravenous heparin infusion to salvage flaps after re‐exploration for postoperative venous congestion after free‐flap breast reconstruction. All flaps were salvaged using local intravenous heparin infusion without major complications. Local intravenous heparin infusion is an effective and safe procedure.
A rare tonsillar metastasis of Merkel cell carcinoma: A case report
Authors: Okonkwo Precious C. , Henning Ania , Plaza Jose , Agrawal Amit , Contreras Carlo M. 
Published: March 2023

AbstractMerkel cell carcinoma (MCC) metastasis to the tonsil is extremely rare with five published cases. We report the case of a patient with palatine tonsillar MCC metastasis, who presented without oropharyngeal symptoms, which contrast prior reported cases.
Trimethoprim/sulfamethoxazole‐induced methemoglobinemia in pediatric patient: A case report
Authors: Alotaibi Sultan , Mously Alaa , Alnujaimy Zainab , Alotaibi Abdulansir , Alharthi Abdullah 
Published: March 2023

AbstractIn this report, a case of high dose of sulfamethoxazole/trimethoprim‐induced methemoglobinemia and is reported in a young boy with ventilator‐associated pneumonia and was treated successfully with methylene blue and cessation of the offending agent.
Comminution of Wood: Single‐Particle Breakage
Authors: Eisenlauer Moritz , Steinhauer Daniel , Klotz Alexander , Jost-Kovács Alma , Wolf Sebastian , Teipel Ulrich 
Published: March 2023

AbstractAn essential element for the sustainable use of renewable resources is an efficient comminution process. For efficient comminution processes, detailed knowledge of the fracturing processes is necessary. Therefore, single‐particle comminution under impact stress was investigated, and the influence of the moisture content and the particle size in single‐particle comminution of beech wood is described. The extent of applicability of the existing models to wood, for modeling the breakage probability function for brittle materials, was investigated.
Immediate exacerbation of atopic dermatitis after switching from upadacitinib to dupilumab: A report of two cases
Authors: Ito Makoto , Kamata Masahiro , Uchida Hideaki , Egawa Shota , Fukaya Saki , Hayashi Kotaro , Fukuyasu Atsuko , Tanaka Takamitsu , Ishikawa Takeko , Tada Yayoi 
Published: March 2023

AbstractJanus kinase (JAK) inhibitors are efficacious for atopic dermatitis (AD). However, some patients receiving JAK inhibitors develop acne, especially younger patients, or herpes zoster, especially elderly patients, and desire to switch to dupilumab. We experienced two patients with immediate exacerbation of AD after switching from upadacitinib to dupilumab, and herein report these cases. This phenomenon is attributed to the difference in elimination half‐life of the two drugs and a slower onset of efficacy of dupilumab than upadacitinib. When switching from a JAK inhibitor to dupilumab, short‐term concomitant use, intensifying topical treatment, and/or rescue with cyclosporine should be considered.
Evaluating Diff‐Quik cytology smears for large‐panel mutation testing in lung cancer—Predicting DNA content and success with low‐malignant‐cellularity samples
Authors: Fielding David I. , Dalley Andrew J. , Singh Mahendra , Nandakumar Lakshmy , Lakis Vanessa , Chittoory Haarika , Fairbairn David , Patch Ann‐Marie , Kazakoff Stephen H. , Ferguson Kaltin , Bashirzadeh Farzad , Bint Michael , Pahoff Carl , Son Jung Hwa , Hodgson Alan , Sharma Sowmya , Waddell Nicola , Lakhani Sunil R. , Hartel Gunter , Nones Katia , Simpson Peter T. 
Published: March 2023

AbstractBackgroundCytology smears are commonly collected during endobronchial ultrasound–guided transbronchial needle aspiration (EBUS TBNA) procedures but are rarely used for molecular testing. Studies are needed to demonstrate their great potential, in particular for the prediction of malignant cell DNA content and for utility in molecular diagnostics using large gene panels.MethodsA prospective study was performed on samples from 66 patients with malignant lymph nodes who underwent EBUS TBNA. All patients had air‐dried, Diff‐Quik cytology smears and formalin‐fixed, paraffin‐embedded cell blocks collected for cytopathology and molecular testing. One hundred eighty‐five smears were evaluated by microscopy to estimate malignant cell percentage and abundance and to calculate smear size and were subjected to DNA extraction. DNA from 56 smears from 27 patients was sequenced with the TruSight Oncology 500 assay (Illumina).ResultsEach microscopy parameter had a significant effect on the DNA yield. An algorithm was developed that predicted a >50‐ng DNA yield of a smear with an area under the curve of 0.86. Fifty DNA samples (89%) with varying malignant yields were successfully sequenced. Low‐malignant‐cell content (<25%) and smear area (<15%) were the main reasons for failure. All standard‐of‐care mutations were detected in replicate smears from individual patients, regardless of malignant cell content. Tier 1/2 mutations were discovered in two cases where standard‐of‐care specimens were inadequate for sequencing. Smears were scored for tumor mutation burden.ConclusionsMicroscopy of Diff‐Quik smears can triage samples for comprehensive panel sequencing, which highlights smears as an excellent alternative to traditional testing with cell blocks.
Safety, Tolerability, and Pharmacokinetics of IMU‐935, a Novel Inverse Agonist of Retinoic Acid Receptor–Related Orphan Nuclear Receptor γt: Results From a Double‐Blind, Placebo‐Controlled, First‐in‐Human Phase 1 Study
Authors: Polasek Thomas M. , Leelasena Indika , Betscheider Irina , Marolt Marija , Kohlhof Hella , Vitt Daniel , Fliegert Frank , Muehler Andreas R. 
Published: March 2023

AbstractRetinoic acid receptor–related orphan nuclear receptor (ROR)γt regulates the transcription of interleukin‐17 and other cytokines implicated in inflammatory and autoimmune diseases. We assessed the safety, tolerability, and pharmacokinetics (PK) of IMU‐935, an inverse agonist of RORγt, in a first‐in‐human phase 1 study. This was a double‐blind, placebo‐controlled trial that randomly assigned healthy subjects single ascending doses (25–400 mg) or multiple ascending doses (150 mg once or twice daily for 14 days) of IMU‐935 or placebo. Dose escalation was determined by the safety, tolerability, and PK. Twenty‐four and 70 subjects received placebo or IMU‐935, respectively. Of the 70 subjects who received IMU‐935, 59 received a single dose and 11 received multiple doses. Treatment‐emergent adverse events (TEAEs) occurred in 21 subjects (88%) and 58 (83%) given any dose of placebo or IMU‐935, respectively. Treatment‐related TEAEs occurred in 6 (30%) and 25 (42%) subjects given a single dose of placebo and IMU‐935, respectively. All treatment‐related TEAEs were mild except for 2 moderate TEAEs and 1 moderate TEAE in the IMU‐935 group and placebo group, respectively. No treatment‐related discontinuations or serious adverse events occurred. The PK of IMU‐935 were dose proportional with a half‐life of ≈24 hours. In conclusion, IMU‐935 was safe with no dose‐limiting toxicities and had a PK profile that supports once‐daily dosing.
Optical Properties and Metal‐Dependent Charge Transfer in Iodido Pentelates
Authors: Möbs Jakob , Stuhrmann Gina , Wippermann Stefan , Heine Johanna 
Published: March 2023

AbstractLead‐free heavy halogenido metalates are currently under intense investigation, as they show similarly promising semiconducting properties as their famous but toxic lead relatives. A major interest in this regard is the understanding and control of optical properties with the goal of designing highly efficient photoconducting materials. Here, we present two isostructural iodido pentelates (Hpyz)3E2I9 ⋅ 2H2O (pyz=pyrazine; E=Sb, Bi). Both compounds are stable up to 100 °C. We observe an inverted order of band gap sizes, 1.91 eV and 1.98 eV for the antimony and bismuth compound, respectively, compared to similar pairs of compounds. We use DFT calculations to confirm that this surprising finding can be traced back to the presence of charge transfer excitations in both compounds.
Magnetic Isolation, RNA Extraction, and Nanostring Analysis of Human Peripheral Blood Leukocytes Subsets
Authors: McFarlin Brian K. , Bridgeman Elizabeth A. , Sass Tatum N. 
Published: March 2023

AbstractAdvancements in multiplexed molecular biology techniques have allowed for blood samples and specific circulating blood leukocytes to be a useful sample source when examining systemic changes associated with changes in body weight, muscle injury, disease onset/progression, and other common conditions. One gap in the current scientific knowledge relates to the impact of changes in individual leukocyte subsets on the overall systemic response. While many studies have published data related to changes observed in a mixed population of circulating leukocytes (i.e., whole blood sample), few studies have identified which cell(s) are responsible for the overall change. Since it is established that leukocyte subsets respond differently to various experimental challenges, it may be possible to gain new insight regarding overall biological state. This has application to a variety of health, nutrition, and exercise intervention models. Despite the need to examine changes in mRNA expression levels in individual leukocyte subsets they are not always easy to isolate and perform mRNA analysis on. In this report we describe a method to magnetically isolate, stabilize RNA, and analyze 800+ mRNA in a single sample analysis. Further we compared total leukocyte and leukocyte subset (i.e., granulocytes, monocytes, and T‐cells) mRNA expression to better understand how subset changes contribute to overall response. Examination of subset responses may provide targets for future intervention studies. © 2023 Wiley Periodicals LLC.Basic Protocol 1: Automated magnetic isolation of granulocytes, monocytes, and T‐cellsBasic Protocol 2: RNA extraction from magnetically sorted granulocytes, monocytes, and T‐cellsBasic Protocol 3: Nanostring analysis of RNA extracted from magnetically sorted granulocytes, monocytes, and T‐cells
Evaluating the potential role of human papilloma virus infection in breast carcinogenesis via real‐time polymerase chain reaction analyzes of breast fine needle aspiration samples from Greek patients
Authors: Mareti Evangelia , Vavoulidis Eleftherios , Papanastasiou Anastasios , Maretis Theodoros , Tsampazis Nikolaos , Margioula‐Siarkou Chrysoula , Chatzinikolaou Fotios , Giasari Sofia , Nasioutziki Maria , Daniilidis Angelos , Zepiridis Leonidas , Dinas Konstantinos 
Published: March 2023

AbstractBackgroundHuman papilloma virus (HPV), in addition to its known clinical contribution to cervical cancer is probably actively involved in the development of breast tumors in various populations worldwide. Predominant HPV types in breast cancer patients vary geographically. The present study further examines HPV incidence in Greece, based on molecular analysis of clinical cytological samples.MethodsGreek patient fine needle aspiration (FNA) biopsy samples were examined using RT‐PCR and immunohistological staining. FNA biopsy samples were collected from 114 female patients, diagnosed between the years 2018 and 2021, 57 with C5 diagnosed breast cancer lesions and 57 diagnosed with benign diseases.ResultsA total of three different HPV types were identified within the patient sample. HPV‐39 was found only in the control group, in 1.8% of patients, while HPV‐59 was present in both control and study groups in 1.8% and 3.5% respectively. HPV‐16, on the other hand, was present only in the study group in 12.3% of cases. HPV type presence was statistically differentiated between histological groups. HPV‐16 was exclusively in IDC, HPV‐39 was present in one cyst diagnosed sample and HPV‐59 was present in 3 samples that included fibroadenoma, IDC and LN diagnosis.ConclusionMore international comparative studies are required to investigate population differences and HPV genotype distribution to offer definite answers to the effect that certain HPV types might have a role in breast cancer, as this study also supports, albeit in a cofactory role.
Historic and contemporary biogeographic perspectives on range‐wide spatial genetic structure in a widespread seagrass
Authors: Sinclair Elizabeth A. , Hovey Renae K. , Krauss Siegfried L. , Anthony Janet M. , Waycott Michelle , Kendrick Gary A. 
Published: March 2023

AbstractHistorical and contemporary processes drive spatial patterns of genetic diversity. These include climate‐driven range shifts and gene flow mediated by biogeographical influences on dispersal. Assessments that integrate these drivers are uncommon, but critical for testing biogeographic hypotheses. Here, we characterize intraspecific genetic diversity and spatial structure across the entire distribution of a temperate seagrass to test marine biogeographic concepts for southern Australia. Predictive modeling was used to contrast the current Posidonia australis distribution to its historical distribution during the Last Glacial Maximum (LGM). Spatial genetic structure was estimated for 44 sampled meadows from across the geographical range of the species using nine microsatellite loci. Historical and contemporary distributions were similar, with the exception of the Bass Strait. Genetic clustering was consistent with the three currently recognized biogeographic provinces and largely consistent with the finer‐scale IMCRA bioregions. Discrepancies were found within the Flindersian province and southwest IMCRA bioregion, while two regions of admixture coincided with transitional IMCRA bioregions. Clonal diversity was highly variable but positively associated with latitude. Genetic differentiation among meadows was significantly associated with oceanographic distance. Our approach suggests how shared seascape drivers have influenced the capacity of P. australis to effectively track sea level changes associated with natural climate cycles over millennia, and in particular, the recolonization of meadows across the Continental Shelf following the LGM. Genetic structure associated with IMCRA bioregions reflects the presence of stable biogeographic barriers, such as oceanic upwellings. This study highlights the importance of biogeography to infer the role of historical drivers in shaping extant diversity and structure.
Herbivores disrupt the flow of food resources to termites in dryland ecosystems
Authors: Wijas Baptiste J. , Cornwell William K. , Letnic Mike 
Published: March 2023

AbstractIrruption of herbivore populations due to the extirpation of predators has led to dramatic changes in ecosystem functioning worldwide. Herbivores compete with other species for their primary source of nutrition, plant biomass. Such competition is typically considered to occur between species in closely related clades and functional groups but could also occur with detritivores that consume senescent plant biomass. In this study, we tested predictions that in ecosystems where herbivores are not regulated by predators, their indirect impacts on dead vegetation increase with primary productivity and extend to termites that feed on senescent vegetation. We compared dead vegetation cover and termite activity in herbivore exclosures and associated grazed plots at three locations situated along a rainfall gradient in arid Australia where kangaroo populations have irrupted. Dead vegetation cover and termite activity increased with rainfall in ungrazed plots but showed a negligible response to rainfall in grazed plots. Our results suggest that grazing can disrupt the flow of energy to detritivores and decouple the relationship between termite activity and primary productivity. Such disruption could have far‐reaching impacts on arid ecosystems because many organisms sit within “brown food webs” that are sustained by energy derived from the decomposition of senescent plant tissues.
Chronotype and sleep disorders in children with epilepsy
Authors: Ozcelik Ayse Aysima , Karadag Mehmet 
Published: March 2023

AbstractObjectiveThe circadian rhythm can affect the frequency and resistance of epileptic seizures. In this cross‐sectional study, we examined the impact of chronobiology and sleep disturbances on children with epilepsy.MethodsOne hundred and twenty‐five children and adolescents (55 patients and 70 controls) were included in the study. All participants were asked to complete the Revised Child Anxiety and Depression Scale—Child Version (RCADS‐CV), Sleep Disturbances Scale for Children (SDSC), Childhood Chronotype Questionnaire (CCQ).ResultsAccording to the CCQ results, controls had longer sleep duration (median 595 vs. 570), lower morningness–eveningness scores (median: 28 vs. 30), and higher rates of the morningness (12.9% vs. 1.8%) and intermediate (74.3% vs. 60%) chronotypes. The children and adolescents with epilepsy scored significantly higher in the Sleep breathing disorders (p = .001), Disorders of arousal nightmares (p = .044), Sleep–wake transition disorders (p = .037), Disorders of excessive somnolence (p = .001), and total SDCS (p = .046) scores. According to the RCADS‐CV results, the children with epilepsy scored significantly higher in all subscales in comparison to controls (p < .05).SignificanceChildren and adolescents with epilepsy had shorter sleep duration were more likely to be evening‐oriented and had more significant sleep disturbance symptoms compared to controls.
Is thalamic deep brain stimulation synergistic with vagus nerve stimulation in drug‐resistant genetic generalized epilepsy?
Authors: Khan Aafreen , Middlebrooks Erik H. , Freund Brin , Grewal Sanjeet , Tatum William O. 
Published: March 2023

AbstractNeuromodulation in epilepsy is a proven treatment for people with drug‐resistant focal epilepsy. Dual device therapies are increasingly utilized in people with drug‐resistant epilepsy. Vagus nerve stimulation (VNS) and deep brain stimulation (DBS) target the thalamus involving the primary neurobiological network in patients with genetic generalized epilepsy (GGE). We report a novel case of combined neuromodulation in a patient with drug‐resistant GGE who achieved a partial response with seizure reduction after VNS implantation yet following VNS‐DBS polyneurostimulation gradually achieved prolonged seizure freedom. We speculate that by combining the indirect activating effects of VNS with the direct inhibitory effects of DBS, this may provide synergy to thalamic modulated networks. We hypothesize a “rational polytherapy” may exist in some patients with GGE undergoing dual neuromodulation.
Functional connectivity between interoceptive brain regions is associated with distinct health‐related domains: A population‐based neuroimaging study
Authors: Luettich Alexander , Sievers Carolin , Alfaro Almagro Fidel , Allen Micah , Jbabdi Saad , Smith Stephen M. , Pattinson Kyle T. S. 
Published: March 2023

AbstractInteroception is the sensation, perception, and integration of signals from within the body. It has been associated with a broad range of physiological and psychological processes. Further, interoceptive variables are related to specific regions and networks in the human brain. However, it is not clear whether or how these networks relate empirically to different domains of physiological and psychological health at the population level. We analysed a data set of 19,020 individuals (10,055 females, 8965 males; mean age: 63 years, age range: 45–81 years), who have participated in the UK Biobank Study, a very large‐scale prospective epidemiological health study. Using canonical correlation analysis (CCA), allowing for the examination of associations between two sets of variables, we related the functional connectome of brain regions implicated in interoception to a selection of nonimaging health and lifestyle related phenotypes, exploring their relationship within modes of population co‐variation. In one integrated and data driven analysis, we obtained four statistically significant modes. Modes could be categorised into domains of arousal and affect and cardiovascular health, respiratory health, body mass, and subjective health (all p < .0001) and were meaningfully associated with distinct neural circuits. Circuits represent specific neural “fingerprints” of functional domains and set the scope for future studies on the neurobiology of interoceptive involvement in different lifestyle and health‐related phenotypes. Therefore, our research contributes to the conceptualisation of interoception and may lead to a better understanding of co‐morbid conditions in the light of shared interoceptive structures.