bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage
Authors: Bao Ximing , Liu Bin , Jiang Yongquan , Feng Tingting , Cao Wanxin , Shi Jiali , Jiang Yiming , Chen Xiaorui , Yang Jie , Li Jiping , Zhou Zheng 
Published: February 2023

AbstractBackground and AimSmall ubiquitin–like modifier (SUMO)‐specific protease (SENP)3 is a protease molecule that responds to reactive oxygen species (ROS) with high sensitivity. However, the role of ROS and SENP3 in the formation of nasal polyps (NPs) remains unclear. This study aimed to explore how SENP3 influenced the outcome of chronic rhinosinusitis (CRS) by altering macrophage function, that is, the formation of NPs.MethodsThe alternative activation of macrophage (M2) was detected with CD68+CD206+ in humans and CD206+ in mice. The nasal mucosa of patients with CRS was tested using flow cytometry (CD68, CD80, and CD206) and triple‐color immunofluorescence staining (CD68, CD206, and SENP3). The bone marrow–derived macrophages from SENP3 knockout and control mice were stimulated with interleukin (IL)‐4 and IL‐13 to analyze alternative macrophage polarization in vitro. An animal model of allergic rhinitis was constructed using SENP3 knockout mice. CD206 was detected by immunofluorescence staining. The thickening of eosinophil‐infiltrated mucosa was detected by Luna staining.ResultsThe number of CD68+ CD206+ M2 increased in the nasal mucosa of patients with CRS with NP (CRSwNP) compared with patients with CRS without NP (CRSsNP), but with no significant difference between the groups. SENP3 knockout increased the polarization of F4/80+CD206+M2. Meanwhile, the number of CD206+M2 significantly increased in the allergic rhinitis model constructed using SENP3 knockout mice and controls, with a more obvious proliferation of the nasal mucosa.ConclusionDownregulation of SENP3 promotes the formation of nasal polyps mediated by increasing alternative activated macrophage in nasal mucosal inflammation.
Benthic nitrate removal capacity in marine mangroves of Guadeloupe, Lesser Antilles
Authors: Laverman Anniet M. , Sebilo Mathieu , Tocny Jennifer , Gros Olivier 
Published: February 2023

AbstractMangrove sediments are known to be potentially active reducing zones for nitrogen removal. The goal of this work was to investigate the potential for nitrate reduction in marine mangrove sediments along a canal impacted by anthropogenic activity (Guadeloupe, Lesser Antilles). To this end, the effect of nitrate concentration, organic carbon load, and hydraulic retention time was assessed as factors affecting these nitrate reduction rates. Nitrate reduction potential was determined using flow‐through reactors in marine mangrove sediments collected along “The Canal des Rotours” in Guadeloupe. Potential nitrate reduction rates, in the presence of indigenous organic carbon, generally increased upon increasing nitrate supply from around 120 nmol cm−3 h−1 (low nitrate) up to 378 nmol cm−3 h−1 (high nitrate). The potential for nitrate reduction increased significantly with the addition of mangrove leaves, whereas the addition of simple, easily degradable carbon (acetate) resulted in an almost fivefold increase in nitrate reduction rates (up to 748 nmol cm−3 h−1). The hydraulic retention time also had an impact on the nitrate reducing capacity due to an increased contact time between nitrate and the benthic microbial community. Marine mangrove sediments have a high potential to mitigate nitrogen pollution, mainly governed by the presence of large amounts of degradable carbon in the form of litter. The mangrove sediments from this Caribbean island, currently exposed to a small tidal effect, could increase their nitrate elimination capacities due to prolonged water retention via engineering.
Performance in (Ultra‐)high‐performance liquid chromatography—How to qualify and optimize instruments in practice
Authors: Jaekel Alexander , Wirtz Michaela , Lamotte Stefan , Legelli Mo 
Published: February 2023

This paper investigates the suitability of an ultra‐high‐performance liquid chromatography/high‐performance liquid chromatography hybrid system for ultra‐high‐performance liquid chromatography applications. Thus, the effect of extra column band broadening, the gradient system, and the injection system were tested and optimized according to their capabilities. An increase of the theoretical plate number up to a factor of two is achieved by the optimization of the extra column volume into the typical ultra‐high‐performance liquid chromatography range (<10 μl). Moreover, for qualitative purposes injections of volumes typical for ultra‐high‐performance liquid chromatography methods are precise. Despite this, a lack of precision and accuracy was determined for the gradient system, and the dwell volume meets the typical specification range for conventional HPLC systems. Therefore, hybrid systems are the intercept between both spectra and are limitedly suitable for ultra‐high‐performance liquid chromatography applications. Another way to approximate ultra‐high‐performance liquid chromatography performance using a high‐performance liquid chromatography system is superficially porous particles. Thus, H/u curves of 5 μm superficially porous and 3 μm fully porous particles were recorded in order to determine the effect of the particle technology resulting in comparable performance of the used stationary phases.
Development of a brief support and education intervention for loved ones of veterans with posttraumatic stress disorder
Authors: Campbell Sarah B. , Caska Wallace Catherine M. 
Published: February 2023

AbstractClinical practice guidelines for managing posttraumatic stress disorder (PTSD) encourage incorporating loved ones into treatment, and supportive relationships can increase engagement in mental health care for veterans with PTSD. This study describes the iterative refinement, feasibility/acceptability testing, and national dissemination of a brief support and psychoeducation intervention for loved ones of veterans with PTSD. Loved ones (n = 181; range:1–11 per group) attended and qualitatively rated “PTSD 101 for Family and Friends: A Support and Education Workshop.” Open‐ended questions were used to gather data on suggestions for improvement and descriptions of helpful content, and the workshop was refined following participant and operational partner feedback using a quality improvement framework. Rating quantitative items on a 1–5 scale, participants found the overall quality (M = 4.76) and relevance (M = 4.82) to be excellent, noting they learned substantial new information (M = 4.45). Sense of support (M = 4.95), intentions to use the material (M = 4.87), PTSD self‐efficacy (M = 4.41), and understanding of PTSD (M = 4.76) were rated favorably. Common themes among helpful elements were a sense of shared experience and optimism and increased knowledge of treatments/resources. Suggestions for improvement referenced logistics. Following continual stakeholder feedback and refinement, the workshop represents a novel method for providing loved ones with empirically supported psychoeducation, coping skills, and community. It is being disseminated by the Family Services Section of the Veterans Health Administration Office of Mental Health and Suicide Prevention.
Extracted samples and in situ soil investigations to assess the effects of different land use and tillage management practices on soil organic matter composition
Authors: Masoudi Malihe , Centeri Csaba , Karlik Máté , Jakab Gergely 
Published: February 2023

AbstractThe effects of land use change on soil organic carbon (SOC) content have been investigated extensively. However, little research has been conducted on how soil organic matter (SOM) chemistry changes under different land use management practices, particularly with different soil cultivation methods. Thus, in this study, we compared the effects of various land use management practices, including six medium‐term tillage practices, namely no‐tillage (zero‐tillage), disking, shallow cultivation, deep cultivation, ploughing, and loosening, and a natural ecosystem, namely tree line, on SOM composition. The present study examined Chernozem soils during spring and autumn under varying land uses in randomised complete block designs, with four replicates at depth increments of 0–10 cm. The SOM composition was characterised using diffuse reflectance infrared Fourier transformat spectroscopy (DRIFTS) and ultraviolet–visible spectroscopy (UV‐VIS). More intensive tillage operations resulted in larger SOM composition changes. Overall, conservation tillage, namely no‐tillage, disking, shallow cultivation, and deep cultivation, SOM was more like the tree line soil than the soil under conventional tillage. Both DRIFTS and UV‐VIS revealed that tree line soil had the lowest aromaticity (15%) and, therefore, a lower decomposition rate and higher SOM recalcitrance compared with the cropland soil (27%). After observing the relationship between tillage operation and aromaticity, aromaticity increased with increasing tillage intensity. This study demonstrates that land use can alter the structure and stability of SOM compounds. We observed that afforestation is similar to conservation tillage, and results are obtained quickly (<40 years). Hence, regeneration agriculture and conservation tillage may be the superior solutions for increasing SOM, sustainable agriculture, and food security in current soil and climate conditions. In addition, DRIFTS measurements of bulk soil provided more detailed information on the quality and stability of SOM than UV‐VIS measurements.
Electron Tunneling Charging upon Sunlight for Near‐Infrared Persistent Luminescence
Authors: Liu Shengqiang , Yang Rujun , Cai Hao , Zhuang Yixi , Song Zhen , Ning Lixin , Liu Quanlin 
Published: February 2023

AbstractFor the conventional persistent luminescence (PersL) charging processes, carriers are photo‐pumped to the conduction band (CB) or high‐energy excited states (HES) under short‐wavelength UV or coherent near‐infrared (NIR) laser excitation. Herein, electron tunneling charging behavior is reported in Cr3+, Sm3+ co‐doped NIR PersL magnetoplumbite SrGa12O19, which allows for efficient charging by incoherent visible light. First, the electrons are efficiently captured by the neighboring GaII‐O2− electron–hole trap centers via a tunneling process, and then these excited electrons are transferred to shallow traps via a persistently energetic optical pump. This work further optimizes the PersL performance via engineering the energy band through partial substitution of In3+ for Ga3+. Consequently, tunneling charging occurring near the neighboring Cr3+‐traps dimers enables Sr(Ga,In)12O19:Cr3+,Sm3+ to display brighter NIR PersL (≈760 nm, peak; ≈100 nm, FWHM) than gallate spinel under sunlight irradiation. This work provides insights into electron tunneling charging under low‐energy excitation for NIR PersL, which may inspire more PersL explorations for practical applications.
Surface‐Initiated Synthesis of Cell‐Specific Glycopolymers Using Live Mammalian Cells as Templates
Authors: Ma Xiaoliang , Luo Yan , Zhang Ping , Hu Jun , Chen Gaojian , Chen Hong 
Published: February 2023

AbstractMolecular recognition is an important process in life activities where specificity is the key. However, the method to gain specificity are often complex and time‐consuming. Herein, a novel, versatile, and effective way is developed to obtain cell‐specific glycosurfaces by surface‐initiated Cu‐mediated reversible deactivation radical polymerization (Cu‐RDRP) in an open to air fashion. Mammalian cells are used for the first time as live templates to realize cell‐sugar monomer‐aptation‐polymerization which can produce cell‐specific glycosurfaces. Both epithelial cell adhesion molecule (EpCAM) positive cells L929 and EpCAM negative cells Hela as models are used to acquire two cell‐specific glycosurfaces, which can distinguish template‐cells from others. The strategy is effective and convenient without the need of fixative pretreatment of cells. It is found that the specific capture does not rely on EpCAM antibodies, and the specificity is related to the composition and chain sequence of the glycopolymer brushes rather than surface morphology. In addition, these glycosurfaces keep the ability to identify the target cells after ten regenerative treatments, which provides another advantage for practical applications.
Amphiphilic photosensitizer polymer as a nanocarrier of cytotoxic molecule for carrier‐free combination therapy
Authors: Xin Jingqi , Deng Caiting , Zheng Meichen , An Feifei 
Published: February 2023

AbstractVarious nanocarriers have been explored to deliver drugs for combination therapy. However, most nanocarriers are composed of inert materials without contribution for improving the cancer therapeutic effect. Herein, a hydrophobic photosensitizer is conjugated to poly (ethylene glycol) to form an amphiphilic polymer, which further self‐assembles into nanomicelle. The generated nanomicelle can act as a nanocarrier to encapsulate a cytotoxic molecule, IR‐775, for combination therapy. The yielded nanodrug is totally composed of pharmacologically active ingredients to avoid any possible toxicity resulted from carrier materials. The nanodrug performs enhanced therapeutic effect compared with any monotherapy and exhibits negligible hemolysis, indicating good biocompatibility for further in vivo applications.
Concurrent management of lymphedema and breast reconstruction with single‐stage omental vascularized lymph node transfer and autologous breast reconstruction: A case series
Authors: Crowley Jiwon S. , Liu Farrah C. , Rizk Nada M. , Nguyen Dung 
Published: February 2023

AbstractIntroductionThe omentum has gained recent popularity in vascularized lymph node transfers (VLNT) as well as its novel use as a free flap for autologous breast reconstruction. The omentum has multiple unique advantages. It can be harvested laparoscopically or in an open fashion when utilized with abdominally‐based free flaps. Additionally, it can be split into multiple flaps for simultaneous autologous breast reconstruction with VLNT or for multiple sites of VLNT. We present the safe and advantageous use of the omentum for VLNT with simultaneous autologous breast reconstruction in a series of patients.MethodsFrom the years 2019–2022, patients who underwent breast reconstruction with deep inferior epigastric artery perforator (DIEP) or muscle sparing tram (MS‐TRAM) flaps with concurrent omental VLNT through a mini‐laparotomy or breast reconstruction with Omental Fat‐Augmented Free Flap (O‐FAFF) with concurrent laparoscopic harvesting of omental VLNT were studied. Patient demographics included age, gender, comorbidities, prior radiation or chemotherapy, body mass index, complications, hospital length of stay, and surgical outcomes.ResultsA total of seven patients underwent omental VLNT with breast reconstruction for a total of 12 breasts and eight limbs treated. Three of the patients underwent autologous breast reconstruction using omental free flap. The mean age was 52.3 (range 40–75) years and mean body mass index (BMI) was 29.3 (range 23–38) kg/m2. The flap survival rate was 100%. All the patients had successful reduction of extremity circumference and improvement of symptoms. The range of follow‐up was 5 to 19 months, with an average follow‐up of 14.6 months. There was only one complication among our 7 patients: a patient with a BMI of 38 developed a post‐surgical abdominal wound treated with local wound care. Otherwise, post‐operative courses were uneventful, and no further complications were reported.ConclusionWe demonstrate here additional evidence to the growing body of literature of the versatility and safety of the omentum to be utilized as an independent tool for surgical treatment of lymphedema as well as its simultaneous use with autologous breast reconstruction.
Thermal Analysis and Pyrolytic Behavior of Bimetal and Double Oxidant Thermite Al/Mg/MoO3/CuO
Authors: Liu Jun‐Wang , Li Shi , Li Mi , Zhou Ying , Guo Tao , Han Zhong‐Xuan , Jiang Lin 
Published: February 2023

AbstractIn order to study the effect of fuel Mg and metal oxide CuO on the reaction of thermite, different proportions of Al‐Mg alloys and MoO3‐CuO metal oxides were prepared by mechanical ball milling, and then the samples of Al1‐xMgx/(MoO3)1‐xCuOx composite thermite were prepared by ultrasonic dispersion method. The samples were characterized by SEM, TG‐DSC, and constant pressure combustion experiments. The results show that in quaternary thermite, adding CuO increases initial exothermic temperature, but increases exothermic heat in high‐temperature regions, and effectively reduces the activation energy of the thermite reaction. On the contrary, adding Mg reduces exothermic heat in the high‐temperature areas, but reduces initial exothermic temperature. After calculation, the quaternary thermite with the best exothermic performance is Al0.8Mg0.2/(MoO3)0.5CuO0.5. Its initial reaction temperature is only 614 °C, but the heat release is up to 2217 J/g. Its activation energy is only 106.7 kJ/mol, but the critical temperature of thermal explosion is up to 927.9 K. At the same time, Al0.8Mg0.2/(MoO3)0.5CuO0.5 has better combustion performance. During combustion, the flame is jet‐like, and the main products are Al2O3, Mo and Cu. This work provides a reference for studying the thermal safety and combustion performance of quaternary thermite.
The critical role of the phytosterols in modulating tumor microenvironment via multiple signaling: A comprehensive molecular approach
Authors: Khan Ashraf Ullah , Khan Adnan , Shal Bushra , Khan Salman , Khan Majid , Ahmad Rizwan , Riaz Muhammad 
Published: February 2023

AbstractCancer is the leading cause of mortality and morbidity worldwide, and its cases are rapidly increasing every year. Several factors contribute to the development of tumorigenesis. including radiation, dietary lifestyle, smoking, environmental, and genetic factors. The cell cycle is regulated by a variety of molecular signaling proteins. However, when the proteins involved in the cell cycle regulation are altered, cellular growth and proliferation are significantly affected. Natural products provide an important source of new drug development for a variety of ailments. including cancer. Phytosterols (PSs) are an important class of natural compounds reported for numerous pharmacological activities, including cancer. Various PSs, such as ergosterol, stigmasterol, sitosterol, withaferin A, etc., have been reported for their anti‐cancer activities against a variety of cancer by modulating the tumor microenvironment via molecular signaling pathways discussed within the article. These signaling pathways are associated with the production of pro‐inflammatory mediators, growth factors, chemokines, and pro‐apoptotic and anti‐apoptotic genes. These mediators and their upstream signaling are very active within the variety of tumors and by modulating these signalings, thus PS exhibits promising anti‐cancer activities. However, further high‐quality studies are needed to firmly establish the clinical efficacy as well the safety of the phytosterols.
The ratio of 2nd to 4th digit length and reproductive function of infertile male patients
Authors: Uchida Masahiro , Iwamoto Teruaki , Yamasaki Kazumitsu , Kariya Fumiko , Konishi Shoko 
Published: February 2023

AbstractPurposeTo investigate the relationship between the ratio of index to ring finger lengths (2D:4D ratio), reflecting androgen exposure in utero, and reproductive function among men.MethodsMale patients (N = 180) who consulted for fertility issues participated in the study. The palms of both hands were scanned, and the 2D:4D ratio was calculated. Data on semen volume, sperm concentration and total motility, total and motile sperm counts, and serum hormone concentrations were obtained. Spearman correlation coefficients between the 2D:4D ratio and hormone and semen quality parameters were calculated.ResultsThe total sperm count was significantly negatively correlated with the 2D:4D ratio of the left hand (r = −0.154, p  = 0.039) but not with that of the right hand (r = −0.045, p  = 0.548). Testosterone showed weak negative correlations with the 2D:4D ratio in the left (r = −0.142, p  = 0.058) and right (r = − 0.149, p  = 0.046) hands. Follicle‐stimulating hormone levels were negatively correlated with the 2D:4D ratios of the left (r = −0.173, p  = 0.020) and right (r = −0.164, p  = 0.027) hands. Other semen quality parameters or luteinizing hormone levels showed no significant correlation with the 2D:4D ratios.ConclusionsNo clear associations were observed between the 2D:4D ratios and reproductive function.
Construction of PANI‐ZnFe2O4/FAC materials with fly ash cenospheres beads as a carrier to enhance the degradation of Methylene Blue
Authors: Qin Yu , Yuan Jinhai , Hu Haikun , Shen Qiqi , Hu Shiyue , Liu Junhong , Luo Xuanlan , Xu Di 
Published: February 2023

AbstractIn this study, zinc ferrate (ZnFe2O4) and polyaniline (PANI) were coated on the surface of FAC by hydrothermal and in situ polymerisation using the floating property of fly ash cenospheres (FAC) to form PANI‐ZnFe2O4/FAC composites. Compared with other reference materials, the PANI‐ZnFe2O4/FAC material not only solves the problem of less easy recycling, but also has significantly enhanced photocatalytic activity for methylene blue (MB). The significant increase in catalytic efficiency is attributed to the synergistic effect of PANI and ZnFe2O4 on the FAC surface resulting in efficient separation and low photogenerated charge complexation rates. In addition, cycling tests have shown the material to be stable and reusable. Active species capture experiments show that ⋅O2− and h+ play a dominant role in the reaction system.
A Developing Community of Collaboration in Indiana
Authors: Berkson Kelly H. , Wamsley James C. , Lotven Samson , Chelliah Shobhana , Van Bik Kenneth , Champlin Sara , Sakhong Kimberly , Par Sui Hnem , Matthews Alina , Bohnert Amanda 
Published: February 2023

AbstractEverywhere humans interact, there is language: in schools and government offices, in songs and stories, in celebrations and mourning. Through language we learn, discuss, and move to address the social and global issues that affect us. This chapter is co-authored by faculty and students, many of whom have expertise in linguistics, the scientific study of human language. While some of our work is abstract, we also care deeply about the human context of language. We often engage with questions such as the following: Who decides which languages are used to create resources? How do forcibly displaced people find information about novel threats like Covid-19? And, crucially, how can we use our expertise to respond to the language-related needs of such a community?
Small Things
Authors: Peutz Nathalie 
Published: February 2023

AbstractIn 2018 and 2019, students from NYU Abu Dhabi spent a week participating, observing, and learning in a refugee camp in Djibouti as a part of an intensive January term course on Displacement and Migration across the Red Sea. This chapter discusses the contours of this student-and-refugee engagement and its relation to the author’s prior ethnographic research and collaborative photography projects in the camp. Revisiting how the university students and their refugee hosts experienced these events, and addressing questions of ethics, value, and privilege, the chapter unsettles common assumptions about who was teaching and helping whom. As flawed and uneven as these educational journeys can be, the chapter argues that what is to be gained from these encounters are not just “small things.”