bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collective Organization Behaviors of Multi‐Cell Systems Induced by Engineered ECM‐Cell Mechanical Coupling
Authors: Wang Xiaochen , Li Hangyu , Zheng Yu , Guan Dongshi , Wang Aidan , Fan Qihui , Jiao Yang , Ye Fangfu 
Published: July 2023

AbstractCells in vivo are surrounded by fibrous extracellular matrix (ECM), which can mediate the propagation of active cellular forces through stressed fiber bundles and regulate various biological processes. However, the mechanisms for multi‐cellular organization and collective dynamics induced by cell‐ECM mechanical couplings, which are crucial for the development of novel ECM‐based biomaterial for cell manipulation and biomechanical applications, remain poorly understood. Herein, the authors design an in vitro quasi‐3D experimental system and demonstrate a transition between spreading and aggregating in collective organizational behaviors of discrete multi‐cellular systems, induced by engineered ECM‐cell mechanical coupling, with the observed phenomena and underlying mechanisms differing fundamentally from those of cell monolayers. During the process of collective cell organization, the collagen substrate undergoes reconstruction into a dense fiber network structure, which is correlated with local cellular density and consistent with observed enhanced cells' motility; and the weakening of fiber bundle formation within the hydrogel reduces cells’ movement. Moreover, cells can respond to the curvature and shape of the original cell population and form different aggregation patterns. These results elucidate important physical factors involved in collective cell organization and provide important references for potential applications of biomaterials in new therapies and tissue engineering.
Phthalocyanine‐Based 2D Polymer for Ultrafast Nonlinear Optical Application
Authors: Liu Fang , Guan Zihao , Wei Zhiyuan , Fu Lulu , Fang Yan , Shan Naying , Zhao Yang , Huang Zhipeng , Humphrey Mark G. , Zhang Chi 
Published: July 2023

AbstractStrong ultrafast nonlinear optical (NLO) responses in near‐infrared (NIR) regions and favorable solution processability are two urgent requirements for practical NLO applications, especially for optical limiting (OL) applications. However, simultaneously optimizing these properties remains significant challenging. In this study, the successful synthesis of a phthalocyanine‐based 2D polymer (Pc‐2DP) is reported; its structure features extended π‐electrons delocalization space constructed by topologically integrating the phthalocyanine units into the 2D framework. The as‐prepared few‐layered Pc‐2DP not only exhibits power‐ and wavelength‐dependent NLO properties toward 35 fs ultrafast pulsed laser, but it also demonstrates excellent ultrafast reverse saturable absorption (RSA) responses in NIR regions. The nonlinear absorption coefficients of Pc‐2DP dispersion reach up to 0.12 and 0.19 cm GW−1 at 800 and 1550 nm, respectively, which are much higher than those of the typical MXene (Ti3C2TX) and molybdenum disulfide with hexagonal structure (2H‐MoS2). The obtained NLO devices exhibit remarkable OL performance at 800 nm and, particularly, in the telecommunication region (1300 to 1550 nm), which is highly desired but seldom reported. The study demonstrates that the as‐prepared Pc‐2DP featuring a highly conjugated aromatic framework is a very promising OL material and that this research provides a new strategy for developing high‐performance 2D organic NLO polymers.
Recent Advances and Development in Visible‐Light‐Mediated Glycosylation: An Expanding Research Area in Glycochemistry
Authors: Azeem. Zanjila , Kumar Mandal Pintu 
Published: July 2023

AbstractIn the last fifteen years, the development of visible‐light photocatalysis, metal/photoredox dual catalysis has become the forefront as a new paradigm in organic synthesis as well as in carbohydrate chemistry. It led to the discovery of unprecedented transformations and also the improvement of known reactions under mild conditions, employing simple household light sources and bench‐stable precursors, which meet the requirements of green chemistry and sustainable development in excellent yield and stereocontrol. In a general sense, the exploitation of photoredox catalysis hinges on the capability of photocatalyst or redox mediator to transform visible light into chemical energy via photo‐irradiated SET (single electron transfer), PET (photoinduced electron transfer), HAT (hydrogen atom transfer), and XAT (halogen atom transfer) to potentially unlock unique reaction pathways, thereby generating a diverse array of reactive intermediates. In view of reaction type, mechanism, and status, this review will systematically summarize the latest advances in visible‐light‐promoted photocatalytic glycosylation reactions, which are driven by single or dual photoredox catalysis and by the photoactivity of electron donor‐acceptor (EDA) complexes.
Xenogeneic Serum‐Free Human Cell‐Derived Tissue Engineered Matrices for the Development of Clinical‐Grade Biomimetic Cardiovascular Devices
Authors: Zaytseva Polina , Visser Valery L. , Ehterami Arian , Hoerstrup Simon P. , Motta Sarah E. , Emmert Maximilian Y. 
Published: July 2023

AbstractThe development of next‐generation biomimetic cardiovascular implants using tissue engineering concepts can address the existing shortcomings of the clinically available prostheses, offering the possibility to generate life‐long, native‐analogous constructs with self‐remodeling and regenerative capacities. Scaffolds for tissue‐engineered cardiovascular prostheses can be obtained from allogenic cell sources, that can then produce human tissue‐engineered matrices (hTEMs) in vitro. Traditionally, fetal bovine serum (FBS) is used as a universal cell growth supplement. However, concerns regarding its biosafety remain a challenge for clinical translation. The aim of this study is to develop a novel xenogeneic serum‐free approach for the manufacturing of clinical grade hTEMs. To achieve this, decellularized hTEMs are generated under xenogeneic serum‐free conditions and have subsequently demonstrated hTEMs perform similarly to the FBS‐supplemented control group in terms of extracellular matrix (ECM) composition, hemocompatibility, thrombogenicity, and calcification potential. Finally, the xenogeneic serum‐free protocol is successfully adapted to the development of hTEM‐based tissue‐engineered heart valves for the systemic circulation, showing proof‐of‐concept functionality in vitro. Overall, the data suggest the effectiveness of xenogeneic serum‐free culture method as a valid alternative to FBS for the production of hTEM for cardiovascular applications.
Functional Bimetal Co‐Modification for Boosting Large‐Current‐Density Seawater Electrolysis by Inhibiting Adsorption of Chloride Ions
Authors: Huang Chuqiang , Zhou Qiancheng , Yu Luo , Duan Dingshuo , Cao Tianyu , Qiu Shunhang , Wang Zhouzhou , Guo Jin , Xie Yuxin , Li Liping , Yu Ying 
Published: July 2023

AbstractDesigning efficient and durable electrocatalysts for seawater splitting to avoid undesired chlorine evolution reaction and resist the corrosive seawater is crucial for seawater electrolysis technology. Herein, a functional bimetal (Co and Fe) is designed specifically to modify nickel phosphide (denoted as CoFe‐Ni2P) for boosting seawater splitting, where the Fe atom improves the conductivity of Ni2P for improving electron transfer, and the Co atom accelerates the self‐reconstruction process to favorably generate bimetal co‐incorporated NiOOH (CoFe‐NiOOH) species on the electrode surface. Additionally, these in situ‐generated CoFe‐NiOOH species remarkably inhibit the adsorption of Cl− ions but selectively adsorb OH− ions, which contributes to excellent performance of the CoFe‐Ni2P electrode for large‐current‐density seawater splitting. Therefore, the CoFe‐Ni2P electrode only requires low overpotentials of 266 and 304 mV to afford current densities of 100 and 500 mA cm−2 in a harsh 6 m KOH + seawater electrolyte, and can work stably for 600 h. Impressively, a flow‐type anion exchange membrane electrolyzer assembled by the CoFe‐Ni2P/Ni‐felt bifunctional electrode is demonstrated to run stably at an industrially large current density of 1.0 A cm−2 in 6 m KOH + seawater electrolyte for 350 h, which shows promising application prospects.
Biochar‐based nutrient management as a futuristic scalable strategy for C‐sequestration in semiarid tropics
Authors: Kuttippurath Jayanarayanan , Abbhishek Kumar , Chander Girish , Dixit Sreenath , Singh Ajay , Das Debabrata , Dey Shiladitya 
Published: July 2023

AbstractClimate and agriculture experts emphasize the need to develop a carbon sink in the soil to help alleviate the effects of climate change. A 2‐year field experiment in semiarid tropical drylands tested sustainable nutrient management approaches to sequester carbon in the soil. We analyzed nine different treatments, including chemical fertilizers (as blanket and soil test‐based [STB] recommendations), sole organic (biochar and compost), and their combinations (with 75% and 50% STB recommendation) as integrated applications (integrated nutrient management [INM]) in the maize–chickpea cropping sequence. We report that biochar treatments show higher (24%–30%) organic carbon stock in the top layer of soil than the respective compost treatments. Furthermore, the biochar‐based INM showed the maximum residual effect in chickpea (Cicer arietinum L.) crops. The system equivalent yield showed the best results (8 Mg ha−1) for 50% need‐based fertilizer and 50% biochar. Although we observed that sole‐biochar sequestered the highest amount of soil organic carbon (0.69%) in the topsoil compared to the other treatments, it was not scalable due to the lower yield for maize crops. Similarly, composts showed more labile carbon concentrations as microbial biomass but lagged behind biochar treatments for organic carbon storage. The system performance expressed as net returns and benefits–cost ratio also showed better results for biochar‐based INM. The findings show that drylands facing widespread land degradation in terms of nutrient imbalances and low C levels will benefit from an integrated approach of need‐based fertilizer with biochar application. Therefore, this might be a long‐term sustainable strategy for C‐sequestration and food security for semiarid tropical drylands.
Reduction in olfactory dysfunction prevalence among patients with diabetes taking metformin
Authors: Vohra Varun , Saraswathula Anirudh , Kamath Vidyulata , Lane Andrew P. , Rowan Nicholas R. 
Published: July 2023

Key points
Metformin treatment is associated with reduced olfactory dysfunction (OD) in diabetic patients
Metformin may possess potential protective effects on olfaction beyond glycemic control
Mendelian randomization study of diabetes and dementia in the Million Veteran Program
Authors: Litkowski Elizabeth M. , Logue Mark W. , Zhang Rui , Charest Brian R. , Lange Ethan M. , Hokanson John E. , Lynch Julie A. , Vujkovic Marijana , Phillips Lawrence S. , Hauger Richard L. , Lange Leslie A. , Raghavan Sridharan ,   the VA Million Veteran Program (MVP)
Published: July 2023

AbstractIntroductionDiabetes and dementia are diseases of high health‐care burden worldwide. Individuals with diabetes have 1.4 to 2.2 times higher risk of dementia. Our objective was to evaluate evidence of causality between these two common diseases.MethodsWe conducted a one‐sample Mendelian randomization (MR) analysis in the US Department of Veterans Affairs Million Veteran program. The study included 334,672 participants ≥65 years of age with type 2 diabetes and dementia case‐control status and genotype data.ResultsFor each standard deviation increase in genetically predicted diabetes, we found increased odds of three dementia diagnoses in non‐Hispanic White participants (all‐cause: odds ratio [OR] = 1.07 [1.05–1.08], P = 3.40E‐18; vascular: OR = 1.11 [1.07–1.15], P = 3.63E‐09, Alzheimer's disease [AD]: OR = 1.06 [1.02–1.09], P = 6.84E‐04) and non‐Hispanic Black participants (all‐cause: OR = 1.06 [1.02–1.10], P = 3.66E‐03, vascular: OR = 1.11 [1.04–1.19], P = 2.20E‐03, AD: OR = 1.12 [1.02–1.23], P = 1.60E‐02) but not in Hispanic participants (all P > 0.05).DiscussionWe found evidence of causality between diabetes and dementia using a one‐sample MR study, with access to individual level data, overcoming limitations of prior studies using two‐sample MR techniques.
Programmable Amine Synthesis via Iterative Boron Homologation
Authors: Xie Qiqiang , Zhang Rui , Dong Guangbin 
Published: July 2023

AbstractThe value of Matteson‐type reactions has been increasingly recognized for developing automated organic synthesis. However, the typical Matteson reactions almost exclusively focus on homologation of carbon units. Here, we report the detailed development of sequential insertion of nitrogen and carbon atoms into boronate C−B bonds, which provides a modular and iterative approach to access functionalized tertiary amines. A new class of nitrenoid reagents is uncovered to allow direct formation of aminoboranes from aryl or alkyl boronates viaN‐insertion. The one‐potN‐insertion followed by controlled mono‐ or double‐carbenoid insertion has been realized with widely available aryl boronates. The resulting aminoalkyl boronate products can undergo further homologation and various other transformations. Preliminary success on homologation ofN,N‐dialkylaminoboranes and sequentialN‐and C‐insertions with alkyl boronates have also been achieved. To broaden the synthetic utility, selective removal of a benzyl or aryl substituent permits access to secondary or primary amine products. The application of this method has been demonstrated in the modular synthesis of bioactive compounds and the programmable construction of diamines and aminoethers. A plausible reaction mechanism, supported by preliminary NMR (nuclear magnetic resonance) and computational studies, is also proposed.
Size‐ and Emission‐Controlled Synthesis of Full‐Color Luminescent Metal‐Organic Frameworks for Tryptophan Detection
Authors: Xia Hai‐Lun , Zhang Jian , Si Jincheng , Wang Hexiang , Zhou Kang , Wang Lei , Li Jingbai , Sun Wen , Qu Lulu , Li Jing , Liu Xiao‐Yuan 
Published: July 2023

AbstractThe development of nanoscaled luminescent metal–organic frameworks (nano‐LMOFs) with organic linker‐based emission to explore their applications in sensing, bioimaging and photocatalysis is of great interest as material size and emission wavelength both have remarkable influence on their performances. However, there is lack of platforms that can systematically tune the emission and size of nano‐LMOFs with customized linker design. Herein two series of fcu‐ and csq‐type nano‐LMOFs, with precise size control in a broad range and emission colors from blue to near‐infrared, were prepared using 2,1,3‐benzothiadiazole and its derivative based ditopic‐ and tetratopic carboxylic acids as the emission sources. The modification of tetratopic carboxylic acids using OH and NH2 as the substituent groups not only induces significant emission bathochromic shift of the resultant MOFs, but also endows interesting features for their potential applications. As one example, we show that the non‐substituted and NH2‐substituted nano‐LMOFs exhibit turn‐off and turn‐on responses for highly selective and sensitive detection of tryptophan over other nineteen natural amino acids. This work sheds light on the rational construction of nano‐LMOFs with specific emission behaviours and sizes, which will undoubtedly facilitate their applications in related areas.
Enhancing the microstructural, optical, and tensile properties of the PVC‐PMMA blend film: The role of PbO nanoparticles incorporation
Authors: El‐Gamal Samy , Khaled M. , Mohammed Ghada 
Published: July 2023

AbstractPVC‐PMMA and PVC‐PMMA‐PbO PNC films were prepared. HR‐TEM confirmed the nanoparticle structure of PbO, while XRD assured its purity, tetragonal structure, with crystallites measuring 35.71 nm. SEM showed the blend surface appeared smooth and homogenous with a fingerprint shape, and loading increased the surface roughness. PbO was reported to be evenly distributed across the blend surface. FTIR confirmed that all blend functional groups are present and the formation of hydrogen bonds between PVC and PMMA, besides the strong interactions between PbO and blend chains. Different optical constants were investigated using UV–vis‐IR spectroscopy. The transmittance of the blend was 81.99% and decreased to 48.14% after loading 4 wt.% PbO (at 500 nm). Loading causes an increase in absorption. The extinction coefficient shows low extinction coefficients (k < 10−6). Loading PbO narrowed the blend band gaps and increased the refractive index n. The carrier's concentration to the electron effective mass was reported. Optical conductivity, energy loss functions, and nonlinear optical parameters were also studied. Tensile properties revealed that loading increased Young's modulus, tensile strength, and elongation at break. The enhancements in optical and mechanical characteristics of PNC films illustrate the possibility of extending their applications to include the semiconductor, electronics, and optics industries.
Deciphering the role of fungus in degradation of polypropylene from hospital waste
Authors: Pallavi Preeti , Rajhans Geetanjali , Kumar Vikas , Kumar Sen Sudip , Raut Sangeeta 
Published: July 2023

AbstractHealth and environmental consequences are unavoidable when it comes to management of hospital waste (HW) disposables. In order to eradicate the HW, this study isolated a novel fungus SPF21 from a hospital dumping yard to degrade Polypropylene (PP). We measured the attributes of PP inoculated with fungus using mass loss, Fourier trans‐form infrared (FTIR), contact angle (CA), and scanning electron microscopy (SEM). The weight of PP exposed to SPF21 was reduced by 25% in 90 days. The SEM images reveal that there are pores all over the sample surface; they alsocaused voids during the biodegradation of PP. FTIR analysis indicates that the spectra of treated mask pieces show the absence of peak at 1746 cm−1 and the appearance of a new peak at 1643 cm−1. A period of 90‐day exposure to the fungal isolate SPF21 reduced the CA of PP by 44.8% when compared to the nonexposed PP samples, suggesting that the surface of PP turned more hydrophilic after exposure. Moreover, our study on PP degradation by the fungus Ascotricha sinuosa SPF21 appears to be promising from the perspective of environmental, health, and economic hazards. Our results indicate that biodegradation greatly facilitates fungus deposition and changes PP film morphology and hydrophilicity.
Applicability of fluorescamine as a fluorogenic reagent for highly sensitive fluorimetric analysis of the tyrosine kinase inhibitor (avapritinib) in pharmaceuticals and biological samples
Authors: Saraya Roshdy E. , Salman Baher I. , Hassan Yasser F. , Hassan Ahmed I. , Refaat Shymaa Abdelsattar , Batakoushy Hany A. 
Published: July 2023

AbstractAvapritinib (AVP) was the first precision drug to be approved by the US Food and Drug Administration (FDA) in 2020 for patients suffering from metastatic gastrointestinal stromal tumors (GISTs) and progressive systemic mastocytosis. The analysis of AVP in pharmaceutical tablets and human plasma was then carried out using a fast, efficient, sensitive, and simple fluorimetric method using a fluorescamine reagent. The procedure is based on the interaction between fluorescamine as a fluorogenic reagent and the primary aliphatic amine moiety in AVP using borate buffer solution at pH 8.8. The produced fluorescence was measured at 465 nm (Excitation at 395 nm). The calibration graph's linearity range was discovered to be 45.00–500.0 ng mL−1. Utilizing the International Council for Harmonization (ICH) and US‐FDA recommendations, the research technique was validated and bioanalytically validated. The proposed approach was effectively employed for determining the stated pharmaceuticals in plasma with a high percentage of recovery ranging from 96.87 to 98.09 and pharmaceutical formulations with a percentage of recovery equal to 102.11% ± 1.05%. In addition, the study was extended to a pharmacokinetic study of AVP with 20 human volunteers as a step for AVP management in therapeutic cancer centers.
Unravelling the components of Chinese college counsellors' mental models: A three‐step coding‐based content analysis
Authors: Qiu Huamin , Zhuang Tengteng , Shi Yin 
Published: July 2023

AbstractThis paper explores the components of Chinese college counsellors' mental models in their daily work based on a rich content analysis of the story accounts of 152 exemplary college counsellors over the past 8 years. On the basis of a rigid three‐step coding procedure, this study reveals that Chinese college counsellors' mental models generally comprise four common constituents, namely a love‐filled faith system, a rule‐based thinking system, a professionalism‐based knowledge system and action‐based performance. These components jointly illustrate the general landscape of Chinese college counsellors' internal well‐being and fill a research gap regarding the sparse attention given to counsellors in the global literature on faculty professionalism.
Is a change in social competencies associated with a change in drug use and crime in substance‐abusing offenders? Evidence from the breaking the cycle demonstration project
Authors: Walters Glenn D. 
Published: July 2023

AbstractBackgroundThe Breaking the Cycle (BTC) Demonstration Project is an intensive drug intervention programme designed to break the cycle of drug use and offending in which many substance‐abusing offenders find themselves trapped, by providing them with alternatives to drug use and crime.AimsTo determine whether an increase in social competencies mediates between any relationship involving enrolment in the Breaking the Cycle Demonstration Project and subsequent drug use or self‐reported offending.MethodsA group of 1088 Project participants (847 males and 241 females) were compared to a set of 987 offenders who received standard probation services alone (756 males and 231 females) using a quasi‐experimental research design.ResultsProject participants reported a significant rise in social competencies and significant reductions in both drug use and self‐reported offending compared to the comparison group. While social competencies mediated the BTC‐subsequent drug use association, drug use did not mediate the BTC‐subsequent social competencies association. The direction of the social competencies–offending relationship was more equivocal in that both progressions (from BTC to social competencies and from BTC to offending) were significant.ConclusionsThese findings add to the evidence of the success of the Breaking the Cycle Demonstration Project in reducing drug use and offending by finding that improvements in social competencies among substance‐abusing participants may be a critical step in reducing drug use. The route to reducing reoffending is not so dependent on a single pathway, although findings suggest that more attention should be paid to both changing and measuring social competencies in future interventions with substance‐misusing offenders.