bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of high intensity interval training versus moderate intensity continuous training on exercise capacity and quality of life in patients with heart failure: A systematic review and meta-analysis
Authors: Gu Shengyuan , Du Xinchao , Wang Dongwei , Yu Yaohua , Guo Shifang 
Published: August 2023

Introduction and aimsHigh intensity interval training (HIIT) is considered as an alternative exercise modality to moderate intensity continuous training (MICT) for heart failure (HF) patients. Yet a growing number of trials demonstrated inconsistent findings about the effectiveness of HIIT versus MICT until SMARTEX study and OptimEx-Clin study have made a consistent negative conclusion that HIIT was not superior to MICT. The aim of this study was to conduct a meta-analysis involving a subgroup analysis of total exercise time (TET) and disease categories of HF to investigate if TET could affect the superiority of HIIT when compared with MICT.Methods and resultsAn electronic literature search of Pubmed, Embase, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov was performed for this review. 16 studies of 661 patients were finally pooled into quantitative synthesis. The weighted mean difference (WMD) and standard mean difference (SMD) with 95% confidence interval (CI) were calculated for quantitative synthesis of outcomes. HIIT was superior to MICT in improving peak oxygen consumption (Peak VO2) (WMD: 1.68 ml · kg-1· min-195% CI: 0.81 to 2.55 n = 661). The subgroup analysis of TET showed that HIIT was superior to MICT in improving Peak VO2in “short time” subgroup (WMD: 1.61 ml · kg-1· min-195% CI: 0.45 to 2.77 n = 166) and in “medium time” subgroup (WMD: 1.74 ml · kg-1· min-195% CI: 0.53 to 2.95 n = 420), and that there was no significant difference between HIIT and MICT in improving Peak VO2in “long time” subgroup (WMD: 0.62 ml · kg-1· min-195% CI: -1.34 to 2.58 n = 75).ConclusionsThe superiority of HIIT to MICT in improving Peak VO2arose in a short to medium length of TET whereas it was effaced by an increment of TET. This “paradox” of TET on HIIT versus MICT might be due to the increasing poor adherence to target exercise intensity over time.Trial registrationPROSPERO registration number:CRD42022375076.
The Role of Macro and Micro Factors in Determining Stock Price: Empirical Evidence of LQ 45 Index Companies
Authors: Sabijono Harijanto , Murni Sri , Trang Irvan , Elim Inggriani , Mangantar Maryam 
Published: August 2023

This study aims to determine and analyze the influence of Profitability, Capital Structure, Exchange Rates and Interest Rates on Investment Risk and their effect on LQ 45 Index Stock Prices. The analysis was conducted on 25 LQ 45 index companies on the Indonesia Stock Exchange (IDX) using report data financial year 2012 to 2020. This study uses an explanatory design using secondary data in the form of JCI, Stock Return, Stock prices and financial report data obtained from LQ 45 Index Companies on the Indonesian Stock Exchange, as well as interest rates and exchange rates sourced from Bank Indonesia and BPS. Samples were taken by purposive sampling of 25 companies for 9 years of observation, using path analysis. The results of the study state that Profitability has no significant effect on Investment Risk, Capital Structure has a significant effect on Investment Risk, Exchange Rates have a positive and significant effect on Investment Risk, Interest Rates have no significant effect on Investment Risk However, Capital Structure has an indirect and significant effect on Stock Price through Investment Risk as an intervening variable. Profitability has a significant positive effect on stock prices, investment risk as an intervening variable between profitability and stock prices indirectly has no significant effect. Capital structure has no significant effect on stock prices, investment risk as an intervening variable between capital structure and stock prices indirectly has no significant effect. Exchange Rate has no significant effect on Stock Price, Investment Risk as an intervening variable between Exchange Rate and Stock Price indirectly has no significant effect. Interest Rates do not have a significant effect on Stock Prices, Investment Risk as an intervening variable between Interest Rates and Stock Prices indirectly does not have a significant effect. Investment risk has no significant effect on stock prices.
Prenatal cadmium exposure has inter-generational adverse effects on Sertoli cells through the follicle-stimulating hormone receptor pathway
Authors: Li Xiaoqin , Lu Zhilan , Du Xiushuai , Ye Youbin , Zhu Jianlin , Li Yuchen , Liu Jin , Zhang Wenchang 
Published: August 2023

In brief
Exposure to cadmium (Cd) during pregnancy can potentially harm the reproductive system of male offspring. This article shows that pregnant woman should be protected from cadmium exposure.

Abstract
Exposure to cadmium (Cd) during pregnancy can potentially harm the reproductive system of male offspring, although the full extent of its heritable effects remains partially unresolved. In this study, we examined the inter-generational impacts of Cd using a distinct male-lineage generational model. Pregnant Sprague–Dawley female rats (F0) were administered control or cadmium chloride (0.5, 1 and 2 mg/day) via intra-gastric administration from gestation day 1 to 20. Subsequently, the first filial generation (F1) male rats were mated with untreated females (not exposed to Cd) to produce the second filial generation (F2). Histopathological analysis of the F1 and F2 generations revealed abnormal testicular development, while ultrastructural examination indicated damage to Sertoli cells. Cd exposure also led to alterations in serum hormone levels (gonadotropin-releasing hormone, follicle-stimulating hormone) and reduced follicle-stimulating hormone receptor (FSHR) protein expression in Sertoli cells in the F1 generation. Furthermore, Cd affected the mRNA and protein expression of FSHR pathway factors and DNA methyltransferase, albeit with distinct patterns and inconsistencies observed between the F1 and F2 generations. Overall, our findings indicate that prenatal Cd exposure, using a male-lineage transmission model, can induce inter-generational effects on male reproduction, particularly by causing toxicity in Sertoli cells. This effect appears to be primarily mediated through disruptions in the FSHR pathway and changes in DNA methyltransferase activity in the male testes.
Seudoartrosis recalcitrante de húmero: técnica de reconstrucción biológica
Authors: Caloia Martín , Meritano Alejandro , González Scotti Diego , Ronconi Sergio , Serur María Emilia , Caloia Hugo , Chamorro Gerónimo , Guevara Herrera Gonzalo , Laboranti Agustina 
Published: August 2023

Introducción: La incidencia de seudoartrosis en las fracturas de húmero tratadas de forma conservadora es del 2-10%, y del 15% en aquellas operadas. La definición de seudoartrosis recalcitrante es aún tema de debate. El objetivo es comunicar los resultados de una serie de pacientes con seudoartrosis recalcitrante de húmero tratados con osteosíntesis estable y reconstrucción biológica con aloinjerto mediante una nueva técnica de montaje.
Materiales y Métodos: La serie incluyó a 33 pacientes evaluados entre 2012 y 2021, 20 mujeres y 13 hombres (edad promedio 65.4 años). El tiempo de evolución de la seudoartrosis recalcitrante era de 33.3 meses. Todos tuvieron un seguimiento promedio de 33.2 meses.
Resultados: Treinta y dos de los 33 pacientes tratados con esta técnica (97%) tuvieron una consolidación completa y uno, una parcial. El período de consolidación promedio fue de 4.6 meses y el de osteointegración completa del aloinjerto, de 8.1 meses. Para la evaluación funcional se consideraron la escala analógica visual, el puntaje ASES, el puntaje de Constant-Murley y los arcos de movilidad del codo.
Conclusiones: El manejo de las seudoartrosis recalcitrantes de húmero sigue siendo un dilema y un problema no resuelto aún para los cirujanos experimentados. La combinación entre el uso de un material de osteosíntesis específico sumado al aloinjerto óseo fijado con tornillos aumenta considerablemente la estabilidad mecánica, permite una movilidad precoz, y actúa como un andamio osteoinductor y osteoconductor vital para la consolidación.
Undergraduate students’ differential performance in introductory course to guidance and counselling at Delta State University, Abraka
Authors: Uloku Ossai Peter Agbadobi 
Published: August 2023

The study examined the differential performance of guidance and counselling and non-guidance and counselling students. The two categories of students received tuition in EDUCATION 402, an introductory course in guidance and counselling. Additionally, guidance and counselling students took other counselling courses in pursuance of their bachelor’s degree. The counterparts from the departments of Educational Management and Foundations as well as Library and Information Science, relied on the knowledge of the introductory course in guidance and counselling. Descriptive survey design was employed in the study. A sample size of 121 students (50 from guidance and counselling department, 32 from Educational Management and Foundations, 39 from Library and Information Science) was drawn from the population of final year students (2020/2021 session) Faculty of Education, Delta State University, Abraka, A 3-item essay test items was the instrument the students responded to. The statistical tool was the independent samples t-test. The data analysed showed statistical significance in favour of guidance and counselling students. This is attributable to their knowledge of other courses in guidance and counselling. It is hereby recommended that students from other departments should be encouraged to take more courses in counselling to enhance their academic performances.
Performance of CA_Markov and DINAMICA EGO models to evaluate urban risk in Antofagasta and Mejillones, Chile
Authors: Henriquez Cristian , Pontius Robert Gilmore 
Published: August 2023

Abstract
The rapid growth of cities worldwide is a phenomenon that has generated numerous debates about the effects it could have on the environment and society. An issue that has not been well addressed in the literature is the relationship between expected urban growth and risks to natural hazards. The relationship is an important aspect for planning because urban expansion is uncertain. In this sense, land change simulation models can be useful tools to address this uncertainty, because simulation models can produce growth scenarios, which allow anticipation of exposure to natural threats. This article compares two land change simulation models: the CA_Markov model in the Selva version of IDRISI and the DINAMICA EGO model. We apply both models to extrapolate areas of future urban gain in the coastal cities of Antofagasta and Mejillones, where there is high exposure to tsunamis, mudslides, and steep slopes. The models can extrapolate differently in terms of both quantity and spatial allocation of urban gain depending on the parameter settings. CA_Markov projected urban growth adjacent to existing urban patches, while DINAMICA EGO simulates greater dispersion and fragmentation given our parameter settings. We conclude that if modelers understand the models’ behaviors, then applying these spatially explicit models to natural risks opens great prospects for urban planning and risk management, especially in countries highly exposed to dangerous natural events, such as in the case of Chile.
Serplulimab plus chemotherapy as first-line treatment for advanced esophageal squamous cell carcinoma: A cost-effectiveness analysis from China
Authors: Shen Jian , Xie Jinping , Jiang Rong , Shao Rong 
Published: August 2023

Abstract
Objective
This study aimed to evaluate the cost-effectiveness of serplulimab plus chemotherapy versus chemotherapy alone as first-line treatment for advanced or metastatic esophageal squamous cell carcinoma (ESCC) with PD-L1 expression of ≥ 1% in China.
Materials and methods
A partitioned survival model was developed based on the ASTRUM-007 clinical trial, which showed that serplulimab plus chemotherapy improved overall survival and progression-free survival compared with chemotherapy alone. Costs and utilities were obtained from the literature and the Chinese healthcare system perspective was adopted. Outcomes included costs, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs). Sensitivity analyses were performed to assess the model uncertainty.
Results
In the overall population and the subgroup with PD-L1 combined positive score (CPS) ≥ 10, serplulimab plus chemotherapy resulted in higher costs and QALYs than chemotherapy alone. The ICERs for serplulimab plus chemotherapy were US$ 68,828.52 per QALY and US$ 71,343.43 per QALY, respectively, which were above the willingness-to-pay threshold of US$ 39,850.27 per QALY in China. Sensitivity analyses showed that the utility of progression-free survival was the most influential parameter.
Conclusion
Serplulimab plus chemotherapy was not a cost-effective option compared with chemotherapy alone for treating advanced ESCC with PD-L1 expression of ≥ 1% in China, from the perspective of the healthcare system.
Root growth and belowground interactions in spring wheat - faba bean intercrops
Authors: Hadir Sofia , Döring Thomas F. , Justes Eric , Demie Dereje T. , Paul Madhuri R. , Legner Nicole , Kemper Roman , Gaiser Thomas , Weedon Odette , Ewert Frank , Seidel Sabine J. 
Published: August 2023

Abstract

Background and Aims: Intercrops offer multiple advantages over sole crops. However, little is known about the mechanisms that govern the belowground interactions between mixed species. The aim of our study was to characterize root growth and interactions in spring wheat-faba bean intercrops for different sowing densities and spring wheat cultivars, evaluating the potential belowground interactions that governs resource capture.
Material and Methods: A field experiment was conducted with one faba bean cultivar and two spring wheat cultivars sown at three sowing densities. Destructive root coring was conducted (0-100 cm) in the intercrops and sole crops at two development stages. The root samples were processed to assess the root mass, root length density, and root carbon and nitrogen concentrations. FTIR spectroscopy was used to discriminate the species’ root masses.
Results: Root mass advantage of intercrops was observed for both cultivars and both development stages especially in the topsoil layers (0-20cm). A negative impact of intercropping on root mass was observed in the treatment with high total sowing density. Complementarity and cooperation were stronger than competition in the topsoil, but competition dominated root growth in the deeper soil layers. Lower sowing densities encouraged deep rooting of wheat (both cultivars) in intercropping. The early root dominance of one spring wheat cultivar impacted negatively faba bean root growth.
Conclusion: Total root mass was affected more by sowing density and less by the spring wheat cultivar in this experiment. An improved understanding of root growth in intercrops can help to support yield advantages and the design of sustainable intercropping systems.
Correlations Between mammographic breast density and outcome after neoadjuvant chemotherapy in patients with locally advanced breast cancer.
Authors: AGARWAL Veenoo , Spalding Lisa , Martin Hilary , Darcey Ellie , Stone Jennifer , Redfern Andrew 
Published: August 2023

Abstract
Background – The inverse association between high mammographic breast density (MBD) and pathologic complete response (pCR), following neoadjuvant chemotherapy (NAC) for early breast cancer (BC), implicates high MBD in chemotherapy resistance. However, no trial has extended the relationship beyond pCR to overall survival.
Aim - To validate the relationship between MBD and pCR in patients undergoing NAC for early BC. To assess the relation of MBD with clinical complete response (cCR), relapse-free (RFS) and BC-specific survival (BCSS).
Methods – MBD was measured in contralateral mammograms in 127 women before NAC, using Cumulus software. Percent dense area (PDA) was correlated with patient and tumour characteristics, short-term (pCR/cCR incidences), and long-term chemotherapy outcomes (RFS and BCSS).
Results - Overall rates of cCR and pCR of 49% and 21% were observed. Mean MBD was higher in those not undergoing cCR (p = 0.041) and relapsing patients (p = 0.041) but did not vary by pCR or BC-deaths. As a dichotomous variable, high MBD corresponded to lower cCR (40 v 58%, p = 0.027). No difference was seen between high and low MBD cohorts for pCR (17.5 v 25.0%, p = 0.15), BC relapse (38 v 30%, p = 0.15) or BC-death (32 v 25%, p = 0.20). A planned analysis in obese patients demonstrated high MBD was associated with lower pCR (0% v 28.1%, p = 0.036) and higher relapse rates (56% v 28%, p = 0.063). No such relationship was observed in non-obese patients.
Conclusion – high MBD associated with lower cCR and higher relapse but not with pCR or BC death. Further analysis, including by body mass index, is warranted.
Global incidence and mortality trends of gastric cancer and predict mortality of gastric cancer by 2035
Authors: Lin Ju-Li , Lin Jian-Xian , Lin Guang-Tan , Huang Chang-Ming , Zheng Chao-Hui , Xie Jian-Wei , Wang Jia-bin , Lu Jun , Chen Qi-Yue , Li Ping 
Published: August 2023

Abstract
Objective
To study the historical global incidence and mortality trends of gastric cancer and predict mortality of gastric cancer by 2035.
Methods
Incidence data were retrieved from the Cancer Incidence in Five Continents (CI5) volumes I-XI, and mortality data were obtained from the latest update of the World Health Organization (WHO) mortality database. We used join-point regression analysis to examine historical incidence and mortality trends and used the package NORDPRED in R to predict the number of deaths and mortality rates by 2035 by country and sex.
Results
More than 1,089,000 new cases of gastric cancer and 769000 related deaths were reported in 2020. The average annual percent change (AAPC) in the incidence of gastric cancer from 2003 to 2012 among the male population, South Korea, Japan, Malta, Canada, Cyprus, and Switzerland showed an increasing trend (P > 0.05); among the female population, Canada [AAPC, 1.2; (95%Cl, 0.5-2), P < 0.05] showed an increasing trend; and South Korea, Ecuador, Thailand, and Cyprus showed an increasing trend (P > 0.05). AAPC in the mortality of gastric cancer from 2006 to 2015 among the male population, Thailand [3.5 (95%cl, 1.6–5.4), P < 0.05] showed an increasing trend; Malta Island, New Zealand, Turkey, Switzerland, and Cyprus had an increasing trend (P > 0.05); among the male population aged 20–44, Thailand [AAPC, 3.4; (95%cl, 1.3–5.4), P < 0.05] showed an increasing trend; Norway, New Zealand, The Netherlands, Slovakia, France, Colombia, Lithuania, and the USA showed an increasing trend (P > 0.05). It is predicted that the mortality rate in Slovenia and France’s female population will show an increasing trend by 2035. It is predicted that the absolute number of deaths in the Israeli male population and in Chile, France, and Canada female population will increase by 2035.
Conclusion
In the past decade, the incidence and mortality of gastric cancer have shown a decreasing trend; however, there are still some countries showing an increasing trend, especially among populations younger than 45 years. Although mortality in most countries is predicted to decline by 2035, the absolute number of deaths due to gastric cancer may further increase due to population growth.
Tracking the migration and distribution of Caspian Kutum (Rutilus kutum, Kamenskii, 1901) along the southern coastline of the Caspian Sea: Using stable isotope analysis
Authors: Abbasi Fatemeh , Ghorbani Rassoul , Salmanmahiny Abdol Rassoul , Trueman Clive Nicholas , Jackson Andrew Llyod , Fazel Abdol Azim 
Published: August 2023

Abstract
Evaluating management strategies for fish catch development requires knowledge of movement patterns and their spatial distribution. The Caspian kutum (Rutilus kutum, Kamenskii, 1901) is an important commercial species throughout the southern coasts of the Caspian Sea. Stable isotope ratios are powerful indexes that simplify the understanding of the migration of aquatic animals. This research determined the stable isotope ratio of carbon (δ13C) and nitrogen (δ15N) for Rutilus kutum movement at 10 sites along the southern coastline of the Caspian Sea from January to December 2017. Spatial and temporal variations in stable isotope values of the coastal communities in the Caspian Sea remain poorly understood. These findings suggest that individual variation, but with a strong overall decline in δ13C and increasing in δ15N and δ13C/δ15N ratio with age, too. These isoscpes showed that the δ15N ratio increased and δ13C decreased from the east (Gomishan) to the west (Astara).
Assessing the integrity of auditory sensory memory processing in CLN3 disease (Juvenile Neuronal Ceroid Lipofuscinosis (Batten disease)): An auditory evoked potential study of the duration-evoked mismatch negativity (MMN).
Authors: Brima Tufikameni , Freedman Edward G. , Prinsloo Kevin D. , Augustine Erika F. , Adams Heather R. , Wang Kuan Hing , Mink Jonathan W. , Shaw Luke H. , Mantel Emma P. , Foxe John J. 
Published: August 2023

Abstract
Background: We interrogated auditory sensory memory capabilities in individuals with CLN3disease (juvenile neuronal ceroid lipofuscinosis), specifically for the feature of “duration” processing, a critical cue in speech perception. Given decrements in speech and language skills associated with later-stage CLN3 disease, we hypothesized that the duration-evoked mismatch negativity (MMN) of the event related potential (ERP) would be a marker of progressively atypical cortical processing in this population, with potential applicability as a brain-based biomarker in clinical trials.
Methods: We employed three stimulation rates (fast: 450 ms, medium: 900 ms, slow: 1800 ms), allowing for assessment of the sustainability of the auditory sensory memory trace. The robustness of MMN directly relates to the rate at which the regularly occurring stimulus stream is presented. As presentation rate slows, robustness of the sensory memory trace diminishes. By manipulating presentation rate, the strength of the sensory memory trace is parametrically varied, providing greater sensitivity to detect auditory cortical dysfunction. A secondary hypothesis was that duration-evoked MMN abnormalities in CLN3 disease would be more severe at slower presentation rates, resulting from greater demand on the sensory memory system.
Results: Data from individuals with CLN3 disease (N=21; range 6-28 years of age) showed robust MMN responses (i.e., intact auditory sensory memory processes) at the medium stimulation rate. However, at the fastest rate, MMN was significantly reduced, and at the slowest rate, MMN was not detectable in CLN3 disease relative to neurotypical controls (N=41; ages 6-26 years).
Conclusions: Results reveal emerging insufficiencies in this critical auditory perceptual system in individuals with CLN3 disease.