bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of Synthesis of Microbial Bio-surfactant Sophorolipids using Response Surface Methodology
Authors: Borde Priti , Mhatre Ninad , Pradhan Subhalaxmi , Madankar Chandu S. 
Published: August 2023

Background:
Synthetic surfactants, when released into the environment, do not degrade
completely and show harmful effects. To minimize the damage to the environment and to
introduce milder surfactants, it was necessary to introduce bio-surfactants.

Objective:
Optimization of the yield is performed by using a design expert model. The analysis of
the product was carried out by using different techniques. The formulation of the personal care
product was prepared by using the sophorolipid produced.

Mode of Synthesis:
Different compositions of raw materials are used, suggested by Design expert
software to optimize the yield of the sophorolipid. Fermentation was performed by the shake
flask method at specified conditions in the incubator shaker for the synthesis. The extraction and
separation of the sophorolipid were done by the solvent extraction method.

Results:
The predicted product yield value is close to the actual value of the product obtained,
which indicates the model is accurate to use. The effect of the raw materials on the yield can be
studied with the design expert model. The product is analyzed for its composition and properties
with different analysis methods.

Conclusion:
Mathematical modelling is very helpful in predicting the optimum reaction condition
and improving the yield of a particular bio-process. The RSM model of design expert software
can be further utilized to carry out the in-detail study of the various factors and their effect
on optimizing the yield. The sophorolipid can be used in different formulations as a greener and
safe alternative to a chemical-based surfactant.
Self-Assessment of the Quality of Life and the Formation of a Healthy Lifestyle of Medical Students
Authors: Shepeleva O. M. , Lazurina L. P. , Kurkina M. P. , Mal G. S. , Dotsenko V. A. , Zavidovskaya K. V. 
Published: August 2023

The purpose of research is to analyze sample data on self-assessment of health and formation of healthy lifestyle attitudes of medical students. Methods. The sample structure is characterized by the distribution of respondents by gender, the course of study at a university and college, and the age of 15–18 years. Data collection was carried out by a questionnaire method using a direct survey of respondents. Anthropometry was performed with the subsequent calculation of the body mass index (BMI) of the respondents. The assessment of the quality of life was carried out using the SF-36 questionnaire on indicators of physical and mental components of health, general health, vital activity and mental health. Results. The respondents were divided into 4 groups: 1 – boys studying at a university, 2 – girls studying at a university, 3 – boys studying at a college and 4 – girls studying at a college. It was found that the surveyed girls have a lower self-assessment of health, more than 30 % of university and college students rate their health as mediocre and poor, and among young men this indicator was 25,0 % and 20,0 %, respectively. The physical component of health differed slightly in the groups. The psychological component of health in girls was: 32,98 ± 1.35 (in high school) and 38,98 ± 1,14 (in college) versus 41,10 ± 2,22 for boys in high school and 44,61 ± 2,12 in college. The indicator of the general state of health was 66,50 ± 4,01; 58,12 ± 2,86; 65,40 ± 4,48 and 63,85 ± 1,95 in representatives of the analyzed groups, respectively; mental health – 63,38 ± 3,83; 49,09 ± 2,63; 64,6 ± 4,48 and 60,34 ± 2,21. Conclusion. Analysis of the data obtained indicates that there are gender differences in self-assessment of health, represented by lower indicators in girls. Moreover, students at the university show this more clearly, which requires more in-depth study. It has been established that first-year students of KSMU have motivation to lead a healthy lifestyle and promote it among the population, and it can be traced more clearly among students of the university.
Electronic Auscultation System: Processing of Auscultatory Data
Authors: Makalov A. O. , Smirnov V. A. , Prokhortsov A. V. 
Published: August 2023

The purpose of research is to increase the diversity of electronic auscultation system designs with measured characteristics and testing. The series of articles includes the development of a model of the electronic auscultation system, the design of an electronic stethoscope, the manufacture of an experimental sample, the development of a methodology for measuring the amplitude-frequency characteristics of electronic and classical stethoscopes, testing of the proposed models and methods, analysis of auscultative data. The article considers mathematical methods of primary analysis of auscultative data. Recordings of normal and hard breathing were used for the experiment. Frequency, time-frequency and autocorrelation analysis of respiratory sounds was performed. Methods. The research was based on the theory of digital signal processing. The study uses auscultative data obtained from an experimental sample of an electronic auscultation system. Electronic records of hard (pathological) and normal human breathing over the left middle lung were used. Respiratory noises were converted into digital form with the following parameters: sampling frequency fd = 48 kHz; bit depth n = 24 bits; number of channels 1. To analyze the frequency information content of the recordings, their spectra were constructed. A fast Fourier transform was used to calculate the values in the spectra. Results. In the presented work, the frequency characteristics of recordings of hard and normal breathing are analyzed. The values of autocorrelation functions are obtained. An author-regression model of the process of normal breathing is obtained. The problem of analytical determination of the model order remains open and requires a separate solution. The resulting model allows you to generate an equivalent breathing noise of inhalation or exhalation when a signal with a uniform is applied to its input. Conclusion. A sample of the electronic auscultation system has been tested, methods of simplified primary analysis of auscultative data have been proposed. The difference in the results of the treatment of hard and normal breathing has no statistical significance due to the small sample.
Evaluation of the Transmission Range of Videoinformation of Various Quality when Monitoring Emergency Situations from an Unmanned Aerial Vehicle
Authors: Alempiev M. Y. , Koptev D. S. , Dovbnya V. G. , Skripkina E. V. 
Published: August 2023

The purpose of research The aim of the study is to estimate the maximum transmission range of video information of various quality from an unmanned aerial vehicle to predict its capabilities when monitoring an emergency situation. Methods. Research methods are based on the concepts of the theory of radio electronics, the theory of diagnostics and prognostics of the technical condition of unmanned aerial vehicles. The methods of multicriteria analysis, parametric and structural synthesis were used. The principles of transmitting video information from unmanned aerial vehicles used to monitor emergency situations are analyzed. A critical assessment of the maximum transmission range of video information from unmanned aerial vehicles during emergency monitoring has been made. Results. Graphs of the dependence of the energy reserve in the radio communication line between the unmanned aerial vehicle and the ground control system have been obtained, allowing to estimate the maximum values of the transmission range of video information of various quality in the 2.4 and 5.8 GHz bands when monitoring emergencies. The maximum line-of-sight range between the UAV and the UAV slightly depends on the lifting height of the antenna of the mobile UAV and at the lifting height of the UAV from 100 to 500 m is from 40 to 85 km. The maximum range of HD quality video transmission with the FM-4 UAV using Turbo 7/8 turbocoding in the 2.4 and 5.8 GHz bands is 3 and 7 km, respectively, and when transmitting FHD quality video information with the CAM-16 UAV using Turbo 7/8 turbocoding in the 2.4 and 5.8 GHz bands is 1.4 and 3.3 km. Conclusion. The development of a method for determining the maximum transmission distance of video and command-telemetry information allows for a more accurate assessment of the energy reserve in the radio communication line with an unmanned aerial vehicle. Unmanned aerial vehicles for direction finding and detection of rescue beacons of victims during search and rescue operations should be considered as promising areas of research in the field of the use of unmanned aerial vehicles in emergency situations.
Efficacy of a Text-Based Mental Health Coaching App in Improving the Symptoms of Stress, Anxiety, and Depression: Randomized Controlled Trial
Authors: Lim Yee Siew , Quek Jia Hui , Ching Xiu Wei , Lim Dominic Tao Ran , Lim Kean Ghee , Thuraisingham Chandramani , George Parikial Philip 
Published: August 2023

Background
Stress, anxiety, and depression are major mental health concerns worldwide. A wide variety of digital mental health interventions have demonstrated efficacy in improving one’s mental health status, and digital interventions that involve some form of human involvement have been shown to demonstrate greater efficacy than self-guided digital interventions. Studies demonstrating the efficacy of digital mental health interventions within the Asian region are scarce.

Objective
This study aimed to investigate the potential efficacy of the digital mental health intervention, ThoughtFullChat, which consists of one-on-one, asynchronous, text-based coaching with certified mental health professionals and self-guided tools, in improving self-reported symptoms of depression, anxiety, and stress. The study also aims to examine the potential differences in efficacy among occupational subgroups and between sexes.

Methods
A randomized controlled study was conducted among housemen (trainee physicians), students, faculty members, and corporate staff at International Medical University, Malaysia. A total of 392 participants were enrolled and randomized to the intervention (n=197, 50.3%) and control (n=195, 49.7%) groups. Depression, anxiety, and stress symptoms were measured using the Depression, Anxiety, and Stress Scale–21 items at baseline and after the 3-month intervention period. The Satisfaction with Life Scale and Brief Resilience Scale were also included, along with a questionnaire about demographics.

Results
Significant decrease was observed in depression (P=.02) and anxiety (P=.002) scores in the intervention group. A subgroup (corporate staff) also demonstrated significant decrease in stress (P=.005) alongside depression (P=.006) and anxiety (P=.002). Females showed significant improvements in depression (P=.02) and anxiety (P<.001) when compared with males.

Conclusions
This study provides evidence that the ThoughtFullChat app is effective in improving the symptoms of depression, anxiety, and stress in individuals, particularly among corporate staff from the educational field. It also supports the notion that mobile mental health apps that connect users to mental health professionals in a discreet and cost-efficient manner can make important contributions to the improvement of mental health outcomes. The differential improvements among occupational subgroups and between sexes in this study indicate the need for future digital mental health app designs to consider an element of personalization focused on systemic components relating to occupation.

Trial Registration
Clinicaltrials.gov NCT04944277; https://classic.clinicaltrials.gov/ct2/show/NCT04944277
Pengembangan Media Pembelajaran Komik Online Untuk Siswa Sekolah Dasar Based Android
Authors: Frialdo Dol , Sukmawati Murni , Irfan Dedy 
Published: August 2023

Tujuan Penelitian ini adalah menjelaskan rancang bangun dan kelayakan media pembelajaran komik untuk siswa sekolah dasar based android. pengkajian ini dibuat menggunakan gaya analisis peningkatan tertentu yaitu dengan pendekatan ADDIE. Metode untuk mengumpulkan data menggunakan formulir serta menggunakan cara tanyajawab. Instrument untuk pengujian kesesuaian menggunakan formulir. Data dikaji secara deskriptif kualitif dan deskriptif statatistik angka. Studi ini menghasilkan 1) Rancangan bangun media komik dalam bentuk android yang didalam ada berisi materi sekolah dasar ppkn, ipa, olahraga, bahasa indoenias disertai gambar komik, percakapan, kuis, dan diaplikasi ini ada tujuan pembelajaran serta panduan memakai aplikasinya. 2) Hasil uji kelayakan buku komik adalah 97,91% positif dari pakar materi pembelajaran, 90,38% positif dari pakar media pembelajaran, 91,67% positif dari pakar desain pembelajaran, 89,58% positif dari pengujian individu, dan 88,42% positif dari pengujian rombongan kecil. Dengan demikian dapat dikatakan bahwa media pembelajaran komik berbasis android dapat digunakan untuk kegiatan pembelajaran bersama anak sekolah dasar.
Kata kunci : Materi, Siswa, Peningkatan, Komik, dan Studi
Siyāsah syar’iyyah and Its Application to Constitutional Issues in Indonesia
Authors: Maimun Maimun , Hakim Dani Amran 
Published: August 2023

Siyāsah syar’iyyah Islamic law politics) is a political doctrine in Islam based on revealed values (sharia), which in practise constructs state laws to regulate, control, manage, and administer the governance and politics of an Islamic nature. This aims to achieve welfare and avoid harm without violating the universal principles and provisions of sharia. This study aims to examine siyāsah syar’iyyah(Islamic law politics) towards constitutional issues in Indonesia. The method used is a literature study with a conceptual approach. Based on its nature, this research is descriptive, and the research data used is secondary. Based on the results of the study, it shows that siyāsah syar’iyyah is a type of siyāsah (Islamic law politics) constructed by the ruler (ulil amri). The formation of laws is based on religious moral values, which are applied to regulate life in society, nation, and state. Siyāsah syar’iyyah (Islamic law politics) can be a part of the application or implementation of constitutional issues in Indonesia that are ongoing, continuous, and will occur especially in the political year (2023-2024) as a barometer to assess whether these issues are categorized as Islamic (‘ādilah) or not (ẓālimah). For Indonesian Muslims in this contemporary era, siyāsah syar’iyyah has become a necessity
COMPARATIVE ANALYSIS OF THE TRAINING OF DOCTOR-FORENSIC MEDICAL EXPERT IN UKRAINE AND EUROPEAN COUNTRIES
Authors: Bachynskyi Viktor , Padure Andrei 
Published: August 2023

Over the past year, radical changes have taken place in Ukraine in the training of specialists in the field of forensic medical examination. In 2022, a decision was made to cancel the internship in forensic medical examination, instead to create specialization courses lasting 468 hours (3 months) after completing the internship in the specialty «Pathology».
Aim of the work. To conduct a comparative analysis of the training of a doctor-specialist in the field of «Forensic Medical Examination» in Ukraine and the countries of Europe.
Results. In Europe, in order to master of the «Forensic Medical Examination» specialty, a residency (similar to an internship) is required, the duration of which varies from 3 to 5 years. In addition to theoretical and practical training in forensic medicine itself, the residency includes training in related disciplines, the list and names of which vary somewhat, depending on the legislation and structure of the forensic medical service of a specific European country (pathology, radiology and radiation diagnostics, orthopedics and traumatology, psychiatry and neurosurgery, etc.).
Conclusions. To return to Ukraine the internship in the specialty «Forensic Medical Examination». To conduct internship training at the departments of forensic medicine through a residency lasting 3.5 years, of which 1.5 years should be devoted to mastering the specialty «pathology» and 2 years to the specialty «Forensic Medical Examination».
ANALYSIS OF DEFECTS IN DIAGNOSIS AND FORENSIC MEDICAL ASSESSMENT OF SKULL BONE FRACTURES
Authors: Olkhovskyi Vasyl , Mykhailychenko Borys , Hurov Oleksandr 
Published: August 2023

Determining the age of skull bone fractures, especially flat fractures, is a challenging task for forensic medical expertise, as these fractures don't always heal properly due to poor alignment of their edges.
Aim of the work. To investigate diagnostic defects and forensic medical expert defects that complicate the assessment of skull bone fractures by analyzing the archive database of the Main Bureau of Forensic Medical Examination of the Ministry of Health of Ukraine for the years 2017-2021.
Materials and methods. The material consisted of 928 forensic medical commission examinations of traumatic brain injuries conducted at the Main Bureau of Forensic Medical Examination of the Ministry of Health of Ukraine from 2017 to 2021.
Statistical indicators were used: mean values, standard deviation (M±ϭ), frequency of cases (N), confidence interval (Р±95%СІ), Student's criterion for relative values (t) to assess the statistical significance of differences between fractions (p<0.05).
Results. Diagnostic defects of skull fractures by physicians included: insufficient detailing of fracture description in medical documentation, unreliability of soft tissue injury description, inadequate use of neurovisualization methods, incorrect recording of trauma circumstances in medical records, and incomplete description of neurological symptoms. The main expert errors in affected individuals were the absence of correlation between skull bone fractures and intracranial injuries and soft tissue head injuries, while in corpses, there was incorrect description of skull fracture morphology.
Conclusion. The use of additional neurovisualization methods and a comprehensive approach correlating all head injuries can improve forensic medical assessment of skull bone fractures.
Антропологічна структура жіночого населення Чернігово-Сіверщини ХVІІ–ХІХ ст.
Authors: Долженко Юрій 
Published: August 2023

Статтю присвячено внутрішньогруповому аналізу жіночої краніологічної серії XVII–ХІХ ст. з Чернігово-Сіверщини. Матеріали для неї були отримані під час розкопок В.П. Коваленка, О.Б. Коваленка, О.П., Моці, О.Є. Черненко, О.М. Веремейчик, Г.В. Жарова, А. Казакова, Ю.М. Ситого, В.І. Мезенцева, З. Когута, В.М. Скорохода, Т.М. Жарової, В.В. Рижого 2009–2021 рр. Всього опрацьовано 53 черепи. В роботі використано комп’ютерні програми, які створили Б.О. Козінцев та О.Г. Козінцев, 1991 р. До внутрішньогрупового багатовимірного аналізу залучено 14 краніометричних ознак за Р. Мартіном. Мета роботи – ввести в науковий обіг новий краніологічний матеріал і після внутрішньо-групового аналізу визначити морфологічну структуру жінок з Чернігово-Сіверщини XVII–ХІХ ст., виявити краніологічні варіанти в її складі. Дати загальну морфологічну характеристику виявленим жіночим варіантам на тлі суміжних етнічних груп України та Східної Європи (синхроністичний метод), визначити відстані між окремими варіантами та серіями XII–XІX ст. за допомогою багатовимірного канонічного та кластерного аналізу й з’ясувати місце цих варіантів з Чернігово-Сіверщини в системі краніологічних типів Східної Європи. Вперше подано внутрішньогруповий аналіз серії жіночих черепів Чернігово-Сіверщини методом канонічного аналізу. До аналізу було залучено 26 жіночих черепів з поховань ХVІІ–ХІХ ст. з Чернігово-Сіверщини. Підтверджено неоднорідність загальної жіночих вибірки, у зв’язку з наявністю у її складі трьох краніологічних варіантів. При порівнянні жіночих досліджуваних варіантів ХVІІ–ХІХ ст. з синхронними та більш ранніми серіями XII–XІX ст. зі Східної, Центральної та Західної Європи методом багатовимірного канонічного та кластерного аналізу відзначено їх подібність до черепів з Волині та певною мірою білоруського полісся та Західного Поділля.
Pharmacokinetics of robenacoxib after a single intramuscular dose in smooth dogfish (Mustelus canis)
Authors: Minich David J. , Fayette Melissa A. , Cox Sherry 
Published: August 2023

Abstract

OBJECTIVE
To determine the pharmacokinetics of robenacoxib after a single intramuscular dose (4.0 mg/kg) in smooth dogfish (Mustelus canis).

ANIMALS
8 healthy adult male smooth dogfish in human care within the same habitat.

METHODS
All sharks received a single intramuscular dose of robenacoxib (4.0 mg/kg) in the right caudolateral epaxial musculature. Blood samples were collected under manual restraint from the ventral tail vessel at 30 minutes, 1 hour, 2 hours, 4 hours, 8 hours, and 24 hours after drug administration. Plasma drug concentrations were determined by HPLC followed by noncompartmental pharmacokinetic analysis of the data.

RESULTS
A maximum plasma concentration of 1.24 µg/mL was reached at a mean time of 30 minutes following robenacoxib administration with a plasma elimination half-life of 3.79 hours. Plasma concentrations did not fall below the lower limit of quantification (0.1 µg/mL) at the time points sampled in this study.

CLINICAL RELEVANCE
Intramuscular administration of a single dose (4.0 mg/kg) of robenacoxib in smooth dogfish resulted in rapid absorption to a maximum concentration at approximately 30 minutes after administration and persisted above levels considered to be therapeutic in domestic species for at least 8 hours.
Analysis of the innovative development path of university civic education based on the era of big data
Authors: Chen Xingang , Dong Ye 
Published: August 2023

Abstract
To enrich the content and form of college civic education, this paper constructs a civic education management innovation platform based on big data technology to explore the innovative development path of college civic education. Using the differentiated fusion algorithm, the information processing of college student management data is carried out, and the educational mining information of college students is identified through feature extraction. Bayesian network is introduced in the process of index weight calculation to improve the data mining efficiency to ensure the validity of obtaining the evaluation index of Civic Education. To verify the feasibility of the innovation platform of Civic Education Management based on big data technology, the application effect was tested. The analysis results show that the platform constructed in this paper can make students’ cognitive awareness of course contents reach 0.98, students’ concentration effect reach 0.89, and the overall effect of teaching feedback reach 90% in selecting teaching resources. The average test score of students in the experimental group was 8.5, and the average length range of the independent learning course was 2.78-4.629 hours. Thus, it can be seen that the platform constructed in this paper is conducive to promoting the high-quality development of Civics teaching and enhancing the effectiveness of Civics education in colleges and universities.