bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of Economic Growth in Special Autonomous Regions: Does Capital Expenditure Important?
Authors: Afiska Rizki Linda 
Published: January 2025

This study aims to examine the influence of balancing funds, special autonomy funds, and regional own-source revenues on economic growth, with capital expenditure as an intervening variable. A purposive sampling method was used, selecting three Indonesian provinces: Aceh, Papua, and West Papua. Data analysis was conducted using panel data regression and path analysis models.The results indicate that balancing funds and regional own-source revenues do not significantly influence capital expenditure, whereas special autonomy funds have a significant positive effect on capital expenditure. Additionally, balancing funds, specialautonomy funds, and regional own-source revenues directly have a significant positive effect on economic growth, while capital expenditure does not significantly impact economic growth. Path analysis further reveals that capital expenditure does not mediate the relationship between balancing funds, special autonomy funds, regional own-source revenues, and economic growth.
Authors: Ismyama Dian Farida , Halizah Siti Nurfitri 
Published: January 2025

Obat antiepilepsi fenitoin telah menjadi pilihan pertama untuk pengobatan kejang sejak diluncurkan pada tahun 1930-an. Mekanisme utama fenitoin adalah stabilisasi membran sel saraf melalui penghambatan saluran natrium sehingga mengurangi depolarisasi neuron yang berlebihan. Review ini bertujuan untuk menjelaskan cara kerja, keamanan dan tolerabilitas fenitoin, serta efek samping dan kontraindikasinya. Penelusuran literatur dilakukan secara terkomputerisasi terhadap artikel-artikel ilmiah yang relevan melalui Pubmed, ScienceDirect, ResearchGate dan Google Scholar. Pencarian literatur juga dilakukan secara manual dari daftar referensi artikel asli untuk menemukan artikel tambahan yang sesuai. Beberapa studi klinis yang dirangkum dalam artikel ini memberikan wawasan tentang bagaimana fenitoin bermanfaat untuk mengobati penyakit selain epilepsi. Fenitoin tidak hanya bermanfaat untuk pengendalian kejang, tetapi juga mempunyai efek neuroprotektif pada neuritis optik akut, dan dapat digunakan untuk mengobati nyeri neuropatik, serta gangguan stres pasca-trauma. Meski demikian, fenitoin termasuk dalam obat dengan rentang terapi sempit sehingga pemakaiannya harus hati-hati. Pemahaman ini penting untuk meningkatkan efektivitas terapi dan mengurangi risiko yang terkait dengan penggunaan fenitoin.
Kata kunci: antiepilepsi; fenitoin; gangguan stres pasca-trauma; indeks terapi sempit; neuroprotektor; nyeri neuropatik
COMMUNITY PHARMACISTS RECOMMENDATIONS ON SELF-MEDICATION FOR GASTROINTESTINAL PROBLEMS: A VIGNETTE CASE STUDY IN EAST SURABAYA
Authors: Djunaidy Vania Denise , Parwitha Ida Ayu Andri , Ferinandra Setyopratami Angela Natasya 
Published: January 2025

Background: Self-medication is a common approach to managing uncomplicated health issues, including gastrointestinal disorders. Community pharmacists are essential in facilitating successful self-medication by thoroughly evaluating patient information, offering rational suggestions, and delivering clear instructions regarding medication administration. Objective: This study aims to characterize pharmacists' abilities in gathering information on patient symptoms and providing appropriate treatment recommendations for self-medication cases of diarrhea and constipation. Methods: This study employed a cross-sectional methodology accompanied by descriptive analysis. Data was collected using two validated vignette case studies: one for measuring information-gathering competencies and another for assessing the correctness of therapy recommendations. Results: 35 pharmacists participated, most of whom had finished professional pharmacist education (88.6%) and had been practicing in pharmacies for 1 to 7 years (40%). The results showed that 66.0% of pharmacists demonstrated moderate information-gathering skills for diarrhea cases and a lower proportion for constipation cases (45.7%). Only 51.4% of pharmacists could provide correct recommendations for diarrhea and constipation cases. Conclusion: These findings highlight the importance of interventions to enhance pharmacists' roles in providing patients with appropriate, safe self-medication services.
Keywords: self-medication; community pharmacists; diarrhea; constipation
Analysis of Granting and Registration Data From the Watershed of the Tributaries of the Upper São Francisco River – SF1, Contained in the IDE-SISEMA
Authors: Santos Flávio Andreote Dos , Borges Luís Antônio Coimbra , Silva Delba Helene Cunha 
Published: January 2025

Objective: This study aims to critically investigate and analyze water resource management in the Watershed of the Tributaries of the Upper São Francisco River (SF1), in Minas Gerais, focusing on the granting processes and registrations of insignificant use. It seeks to understand the relationships between the growth of water grants and registrations and socioeconomic variables, such as GDP per capita, population, and land coverage for agriculture

Theoretical Framework: The analysis is based on the principles of integrated water resource management and the guidelines of the National Water Resources Policy, considering technical, social, and environmental aspects. Previous studies emphasize the relevance of efficient monitoring and auditing systems in water resource management.

Method: The methodology adopted for this research includes an exploratory and descriptive approach, with a documentary analysis of data extracted from IDE-SISEMA and a systematic literature review. The data covers the period from 2018 to 2022 and includes information on grants, registrations, and socioeconomic variables in the SF1 watershed.

Results and Discussion: A significant increase in water grants was observed from 2018 onwards, accompanied by a higher proportion of insignificant use registrations. However, correlations between socioeconomic variables and the number of water grants did not show statistical significance. Water resource management in SF1 highlights challenges in balancing water demand and conservation efforts.

Research Implications: The practical and theoretical implications of this research highlight the need for more efficient audits and the inclusion of measurable data in registrations to enhance oversight and management of water resources, providing support for more effective public policies.

Originality/Value: This study contributes to the literature by evidencing unique patterns and challenges in water resource management in SF1, emphasizing the importance of more rigorous methodologies for the sustainable use of water resources.
Ethnobotany in Riverine Communities in the South of the Amazon
Authors: Furtado Fabiana Caetano , Cruz Sandro Beleza , Bezerra Francilel Arruda , Silva Douglas Marcelo Pinheiro da , Oliveira Benone Otávio Souza de , Lima Renato Abreu 
Published: January 2025

Objective: Analyze the importance of medicinal plants and the ethnobotanical knowledge transmitted among riverside communities in southern Amazonas.

Theoretical Framework: The importance of medicinal plants for riverside communities, discussing the use of plants as a therapeutic alternative due to the lack of access to conventional medical care.

Method: This work used a systematic bibliographic review to analyze studies on ethnobotany in riverside communities in southern Amazonas between 2002 and 2022, addressing interactions between society and biodiversity, sustainability, and environmental conservation. Renowned authors were consulted to identify patterns and gaps in knowledge. The methodology allowed a holistic and interdisciplinary view of the topic, highlighting the importance of biodiversity conservation.

Results and Discussion: The results show that medicinal plants are essential for the health and cultural identity of communities, often replacing inaccessible conventional treatments. Ethnobotanical research not only documents these practices but also proposes conservation strategies.

Research Implications: The research promotes the conservation of biodiversity, proposing strategies that respect traditional knowledge about medicinal plants, essential for environmental sustainability. It highlights the role of these plants in promoting preventive and therapeutic health, especially in areas where medical care is difficult to access. Furthermore, reinforce the importance of documenting and preserving this knowledge to strengthen the cultural resilience of riverside communities in the face of current pressures.

Originality/Value: The originality of the research lies in its interdisciplinary approach, connecting health, culture and environmental conservation. The study offers a holistic view that links communities' ancestral knowledge to sustainability. In addition to documenting this knowledge, research serves as the basis for public policies that promote environmental conservation and value traditional knowledge. This strengthens the autonomy of riverside communities.
Grain Production in Brazil: Evolution of Plantations and Environmental Impact
Authors: Moraes Filho Rodolfo Araujo de , Silva Letícia da Costa e , Albuquerque José de Lima , Cabral Romilson Marques , Silva Ana Maria Navaes da , Rodrigues Gilberto Gonsalves 
Published: January 2025

Objective: The objective of this study is to investigate how grain production is structured in Brazil, what quantities are produced in which geographical spaces and, above all, whether the expansion of plantations has caused environmental impact.

Theoretical Framework: The model for modern agriculture adds, in addition to the concept of sustainability, the certified traceability of production. The concept of responsible consumption has grown lately, and this is a warning sign for eventual producers who try to distance themselves from these principles and start incorporating environmentally protected lands.

Method: The research, of a qualitative-quantitative nature, made use of the method of Factor Analysis of Correspondences, to map the profile of the different cultures in the country. In the qualitative part, it used the technique of discourse analysis (Foucault, 1987) through direct observation (non-participant) from data collected on the subject, from the corporate media and institutional powers.

Results and Discussion: The results showed that the structure of the plantations is concentrated in the production of Soybean and Corn, representing 86.7% of all grain production in the country. That these two crops have grown with the incorporation of new lands in the Legal Amazon region, generating a strong environmental impact. That the constant deforestation in the Cerrado region, a territory with high aquifer potential, has been compromising the springs of the main hydrographic basins of South America (Amazon/Tocantins, São Francisco and Prata.

Research Implications: The research provides valuable information about the seriousness of the situation regarding the prospect of expansion of the complex (Soybean/Corn) in the Amazon. And, the consequences that all this represents for the problem of climate change due to aggressions to the environment.

Originality and Value: The productive profile of each region, drawn in the density graph of the Factor Analysis of Correspondences (CFA) is an originality. The finding that grain production in Brazil follows adequate sustainability standards with the exception of Soybeans and Corn, and the criticism made to this part of agribusiness that has been generating negative externalities with serious damage to the environment is relevant information with value for public policies.
Decompression venous gas formation intensity scale
Authors: Klenkov I. R. , Palenyi S. R. , Bychkov S. A. 
Published: January 2025

Relevance. Severe decompression sickness is the most common diving disorder; therefore, its diagnosis and prevention is considered important aspects of hyperbaric physiology and diving medicine. Diver’s susceptibility to gas bubble formation under decompression is most critical for decompression sickness prevention. Doppler bubble detection is the most common procedure to identify divers who are most susceptible to gas bubble formation under decompression; nevertheless, a more comprehensive examination including pulse pressure and 2D visualization of gas bubbles provide valuable advantages.The objective is to provide justify the implementation of the decompression risk and venous gas bubble formation scale.Methods. The study enrolled 42 divers who were examined for tolerance to gas bubble formation under decompression; gas bubbles were visualized using Doppler ultrasound. Next, the developed decompression risk and venous gas bubble formation scale was used to verify its efficiency and practical value.Results and discussion. After hyperbaric exposure, 2D gas bubble visualization data were analyzed showing that 6 subjects (14.3 %) had no decompression-caused gas bubble formation (0 points); 9 subjects (21.4 %) scored up to 5 points, showing a small amount of gas bubbles during exercise; 22 subjects (52.4 %) scored between 6 and 15; whereas the remaining 5 subjects presented with gas bubbles at rest and a sharp increase in bubble formation during mild exercise. The obtained data suggest that the examined diver cohort included 13 subjects (31 %) with very high tolerance to gas bubble formation, 21 divers (50 %) showing average tolerance and 8 highly susceptible subjects (19 %).Conclusion. During decompression, venous gas bubble formation scale has significant diagnostic value providing a tool to measure individual diver’s susceptibility to gas bubble formation. The scale allows to reduce the hyperbaric load by decreasing exposure on the ground at threshold pressure (0.4 MPa) and thus reduce the decompression time, based on sufficient evidence regarding individual susceptibility to gas bubble formation under decompression
Translating tissue expression of STAT 1, 3 and 6 in prurigo nodularis to clinical efficacy of oral tofacitinib – A prospective single-arm investigational study
Authors: Sardana Kabir , Mathachan Sinu Rose , Muddebihal Aishwarya , Agrawal Diksha , Ahuja Arvind 
Published: January 2025

Background
Interleukin (IL)-4, IL-13, IL-17, IL-22 and IL-3 are overexpressed in prurigo nodularis (PN). They mediate their action via the Janus Kinase (JAK) Signal transducer and activator of transcription (STAT) pathway.

Objectives
Our aim was to study the expression of tissue STAT1, STAT3, and STAT6, as well as the efficacy of the JAK-STAT inhibitor, tofacitinib, in PN.

Methods
A prospective study was conducted in a tertiary care hospital. Patients with PN were recruited after excluding secondary causes. Pruritus was graded using Pruritus Grading System Score (PGSS). All cases underwent histological assessment using immunohistochemical markers for STAT1, STAT3, and STAT6 in both lesional and perilesional skin. Tofacitinib was initiated at a dose of 5 mg twice daily or 11 mg once daily and then tapered to a maintenance dose. The final PGSS at the time of data evaluation, as well as the occurrence of remissions and relapses, was assessed.

Results
The majority of the 17 patients included in the study had moderate to severe disease. Immunohistochemical analysis revealed marked tissue expression of STAT6 in 13 and STAT3 in 10 patients, while STAT1 expression was seen in only 4 patients [p < 0.05], suggesting a Th2/Th17 tissue response. The mean onset of action of tofacitinib was 11.2 ± 6.44 days and the mean duration of treatment was 5.6 ± 2.2 months. A significant reduction in PGSS was noted after treatment (66.1%, P value 0.0004). Fourteen of the patients maintained remission on low-dose therapy (5 mg OD or A/D) while one patient experienced a relapse. No serious adverse effects were noted.

Limitation
We could not study the tissue cytokines and the expression of STATs after achieving clinical response on oral tofacitinib.

Conclusion
The efficacy of tofacitinib in PN is based on its inhibitory effect on Th2 and Th17 cytokines, which is dependent on STAT6 and STAT3.
Assessing second-hand smoke exposure among non-smoking youth in India: Insights from GATS I & II
Authors: Chopra Mansi , Gupta Amrita , Sharma Bhavya , Kakade Narendra , Arora Monika 
Published: January 2025

Background & objectives
This study aimed to compare the prevalence and identify the patterns of second-hand smoke (SHS) exposure among non-smoking Indian youth (ages 15-24 and 25-29 yr) in various settings-homes, workplaces, public places, and a combination of these locations-based on sociodemographic factors and knowledge about the health implications of smoking. The purpose of the study was to identify the factors influencing SHS exposure in India between the Global Adult Tobacco Survey (GATS) I and II.

Methods
Secondary data analysis was conducted utilising GATS I and II data to analyse the prevalence and patterns of SHS exposure at home, workplace, public place and all the places combined among non-smoking youths aged 15-29 yr. The study sample included 20,604 and 20,927 individuals for GATS I and II, respectively. The predictor variables included the sociodemographic variables and the knowledge regarding the ill effects of smoking. Weighted prevalence was calculated using survey weights, and multivariate logistic regression analyses were utilised to examine the adjusted relationships between SHS exposure and predictors.

Results
Between GATS I and II, there was a notable decline in the weighted prevalence of SHS exposure at home and in public places among non-smoking youth aged 15-29 yr. The study also indicates an increase in workplace SHS exposure between the two rounds of GATS among non-smoking youth who had knowledge about the ill effects of SHS exposure on health. Multivariate regression analyses revealed significant associations between SHS exposure and gender, education level, employment status, place of residence, and wealth index, affecting exposure in one or more locations.

Interpretation & conclusions
Our secondary analysis of GATS data from 2009-10 to 2016-17 reveals a decline in SHS exposure at home and public places but an increase in workplaces among non-smoking youth. Factors like female gender, higher education, and wealth were linked to lower SHS exposure, while rural residence and self-employment indicated higher risks. These findings underscore the need for targeted, community-based interventions and stricter enforcement of anti-tobacco laws to protect non-smoking youth in India.
Recent HCMV infection in early pregnancy associates with congenital transmission & adverse pregnancy outcome: A prospective cohort study
Authors: Palav Harsha Chandrashekhar , Padwal Varsha Sakharam , Velhal Shilpa Milind , Yadav Sapna , Bhonde Gauri Sanjay , Kalsurkar Varsha , Agrawal Sachee , Set Reena , Shastri Jayanthi , Shah Forum , Shah Ira , Satoskar Purnima , Patel Vainav , Bhor Vikrant Madhukar 
Published: January 2025

Background & objectives
Human Cytomegalovirus (HCMV) infection, leading to >90 per cent seropositivity in women of reproductive age from India, is the largest cause of congenital infections worldwide. HCMV infection status was prospectively monitored together with congenital transmission (cCMV) and adverse pregnancy outcomes (APO) in a public health setting where maternal or neonatal screening was not in practice.

Methods
Eighty three pregnant women, with (n=45) and without (n=38) bad obstetric history (BOH), were monitored for HCMV infection by ELISA-(IgM, IgG, IgG avidity) for all TORCH (Toxoplasma, Rubella, HCMV, HSV 1 & 2) pathogens along with HCMV-specific chemiluminescent microparticle immunoassay (CMIA) and nested polymerase chain reaction (PCR). Descriptive statistics were applied on data sets to determine associations between maternal infection status, pregnancy outcome and cCMV in 52 mother-neonate dyads.

Results
Combined avidity, PCR-based and HCMV IgM screening, compared to the latter alone, was successful in identifying incident infection during early pregnancy. Pregnancy loss was associated strongly with BOH and concurrent HCMV infection. Features associated with APO and cCMV, were high PCR positivity (first trimester) and high rates of HCMV-specific IgM and intermediate IgG avidity (P=0.0211, 0.0455). Also, recent HCMV infection (intermediate IgG avidity), observed mainly in the BOH group, but not recurrent infection (IgM positivity), in first and second trimesters, was associated with neonatal saliva positivity and adverse outcomes, including neonatal death (P=0.0762). Exposure to other TORCH pathogens, while detected, did not include IgM positivity or low/intermediate IgG.

Conclusion
This study highlights the significance of conducting early, multi-pronged screening for maternal HCMV infection during pregnancy, especially in public health settings with high HCMV seroprevalence.
Метод и система Контроля и управления процессом нанесения катализатора на ориентированные углеродные нанотрубки при изготовлении электродов ТВЕРДООКСИДНЫХ ТОПЛИВНЫХ ЭЛЕМЕНТОВ
Authors: Образцов Д.В. , Платёнкин А.В. , Чернышов В.Н. 
Published: January 2025

Рассмотрен метод и система технологического контроля процессом нанесения катализатора на синтезированные углеродные нанотрубки (УНТ), ориентированные перпендикулярно к поверхности электродов твердооксидных топливных элементов (ТОТЭ). Метод включает в себя четыре этапа: синтез зародышей катализатора на электродах ТОТЭ, рост островкового катализатора, выращивание УНТ на островках катализатора, нанесение катализатора на внешние и внутренние поверхности УНТ с помощью предложенных устройства и алгоритма вращения электродов в процессе напыления, позволяющих производить равномерное нанесение катализатора. Предложенный подход позволят получить на поверхности электродов слой катализатора с высокой активной площадью, что способствует существенному увеличению мощности ТОТЭ и уменьшению их массогабаритных параметров. Разработанная система позволяет осуществить контроль высоты растущих УНТ в процессе химического осаждения из газовой фазы. Экспериментальная проверка разработанного метода и системы контроля и управления показала кратное увеличение активной площади катализатора на поверхности электродов ТОТЭ, что, в итоге, существенно повысило их мощность.
The method and system of technological control of the process of applying a catalyst to synthesized carbon nanotubes (CNT) oriented perpendicular to the surface of the electrodes of solid oxide fuel cells (SOFC) are considered. The method includes four stages: synthesis of catalyst nuclei on TTE electrodes, growth of an insular catalyst, growing CNT on catalyst islands, applying the catalyst to the outer and inner surfaces of CNT using the proposed device and the algorithm of rotation of the electrodes during spraying, allowing for uniform application of the catalyst. The proposed approach will make it possible to obtain a catalyst layer with a high active area on the surface of the electrodes, which contributes to a significant increase in the power of the SOFC and a decrease in their weight and size parameters. The developed system makes it possible to control the height of growing CNT in the process of chemical deposition from the gas phase. The experimental verification of the developed method and the monitoring and control system showed a multiple increase in the active area of the catalyst on the surface of the SOFC electrodes, which, as a result, significantly increased their power.