bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of functional spray coatings on smoke volatile phenol compounds and Pinot noir grape growth
Authors: Tran Trung T. , Jung Jooyeoun , Garcia Lindsay , DeShields Joseph B. , Cerrato D. Cole , Penner Michael H. , Tomasino Elizabeth , Levin Alexander D. , Zhao Yanyun 
Published: December 2022

AbstractThe frequency and intensity of wildfires have been increasing over the last 50 years and negatively impacted the wine industry. Previous methods of smoke mitigation during grape processing have shown little impact in reducing smoke taint in wines. Therefore, a novel method of using edible spray coatings for vineyard application was developed to help prevent volatile smoke phenol uptake in wine grapes. Four cellulose nanofiber‐based coating suspensions incorporated with chitosan and/or β‐cyclodextrin were evaluated. Films derived from the coating suspensions were exposed to volatile phenols found in wildfire smoke (guaiacol, 4‐methyl guaiacol, m‐cresol, o‐cresol, p‐cresol, syringol, and 4‐methyl syringol) and evaluated with ultraviolet‐visible spectroscopy where the results indicated that the coatings could uptake smoke phenols in varying degrees. The coatings were also applied in a vineyard at three different application times during grape growth: pea‐sized, pre‐bunch closure, and both at pea‐sized and pre‐bunch closure. The results showed that the application time did not have a significant (p < 0.05) effect on berry size, weight, °Brix, pH, or titratable acidity. The type of coating, time of application and washing were found to impact the number of volatile phenols in the grapes after a smoke event. Results from this study indicated that edible coatings could help mitigate smoke uptake in wine grapes without sacrificing the growth and key composition parameters of wine grapes.Practical ApplicationThis research provides a novel spray coating that can be applied to wine grapes in the vineyard to potentially mitigate volatile smoke compounds in wine grapes without impacting fruit growth and key compositional parameters of wine grapes, thus maintaining high quality of wines for consumers. Results from this study can also be potentially applied to other agricultural commodities to solve the issues caused by the wildfire smoke.
Mitigating crop raiding by forest elephants and baboons at Kibale National Park
Authors: Kyokuhaire Anna Muchwampaka , Chapman Colin A. , Omeja Patrick A. , Tumusiime David Mwesigye , Abwoli Banana Yabezi , Lawes Michael J. 
Published: December 2022

AbstractIn Africa, most protected forests are in densely human‐dominated landscapes where human–wildlife conflict is intense. We documented farmer perceptions and responses to crop‐raiding wildlife from Kibale National Park, Uganda. Crop raiding was mostly (95%) by baboons (Papio anubis) and elephants (Loxodonta africana). While the financial loss caused by baboons and elephants did not differ, elephants were perceived as more damaging. Guarding and trenches were perceived as the most effective deterrent strategies for baboons and elephants, respectively. Distance from the park boundary and household income were significantly associated with a greater likelihood of crop raiding. Distance from the park, household head age and the species that raided crops, influenced whether a household applied one or more deterrent strategies. Households headed by women or older adults were most vulnerable, experiencing greater losses to raiding. Patterns of human–wildlife conflict around Kibale forest are complex, but the extent of crop damage was mostly determined by distance from the park and farm socio‐economic status and thus their ability to mitigate or deter raiding. Managing crop raiding requires collaboration between the park and affected farmers to ensure that mutually managed deterrent methods, such as trenching (elephants) and guarding (baboons), are effectively shared, applied and maintained.
Effectiveness and safety of risankizumab induction therapy for 100 patients with Crohn's disease: A GETAID multicentre cohort study
Authors: Fumery Mathurin , Defrance Antoine , Roblin Xavier , Altwegg Romain , Caron Benedicte , Hébuterne Xavier , Stefanescu Carmen , Meyer Antoine , Nachury Maria , Laharie David , Nancey Stephane , Le Berre Catherine , Serrero Melanie , Geyl Sophie , Giletta Cyrielle , Ah‐Soune Philippe , Duveau Nicolas , Uzzan Mathieu , Abitbol Vered , Biron Amelie , Tran‐Minh My‐Linh , Paupard Thierry , Vuitton Lucine , Elgharabawy Yasmine , Peyrin‐Biroulet Laurent 
Published: December 2022

SummaryBackgroundPhase III trials have demonstrated the efficacy of risankizumab in moderate‐to‐severe Crohn's disease (CD), but no real‐world data are currently available. We aimed to assess the short‐term effectiveness and safety of risankizumab in patients with CD.MethodsFrom May 2021 to May 2022, all patients with refractory luminal CD treated with risankizumab in 22 French GETAID centres were retrospectively included. The primary endpoint was steroid‐free clinical remission at week 12 (Harvey‐Bradshaw [HB] score <5). Secondary endpoints included clinical response (≥3‐point decrease of HB score and/or (HB) score <5), biochemical remission (CRP ≤ 5 mg/L), need for CD‐related surgery and adverse events.ResultsAmong the 100 patients included, all have been previously exposed to anti‐TNF agents, 94 to vedolizumab, 98 to ustekinumab (all exposed to at least three biologics) and 61 had a previous intestinal resection. All but three (97%) received a 600 mg risankizumab intravenous induction at weeks 0–4–8. At week 12, steroid‐free clinical remission was observed in 45.8% of patients, clinical remission in 58% and clinical response in 78.5%. In subgroup analysis restricted to patients with objective signs of inflammation at baseline (n = 79), steroid‐free clinical remission at week 12 was observed in 39.2% of patients. Biochemical remission was observed in 50% of patients. Six patients discontinued risankizumab before the week 12 visit due to lack of efficacy. CD‐related hospitalisation was needed in six patients, and three underwent intestinal resection. In multivariable analysis, only a history of ustekinumab loss of response (vs primary failure) (odds ratio (OR), 2.80; 95% CI: 1.07–7.82; p = 0.041) was significantly associated with clinical remission at week 12. Twenty adverse events (AE) occurred in 20 patients including 7 serious AE corresponding to 6 CD exacerbation and one severe hypertension.ConclusionIn a cohort of highly refractory patients with luminal CD and multiple prior drug failures including ustekinumab, risankizumab induction provided a clinical response in about 3 out of 4 patients and steroid‐free clinical remission in about half of patients.
Intrapartum pudendal nerve block analgesia and childbirth experience in primiparous women with vaginal birth: A cohort study
Authors: Waldum Åsa Henning , Lukasse Mirjam , Staff Anne Cathrine , Falk Ragnhild Sørum , Sørbye Ingvil Krarup , Jacobsen Anne Flem 
Published: December 2022

AbstractBackgroundA negative childbirth experience has short‐ and long‐term consequences for both mother and child. This study aimed to investigate the association between intrapartum pudendal nerve block (PNB) analgesia and childbirth experience.MethodsPrimiparous women with a singleton cephalic vaginal live births at term at Oslo University Hospital from January 1, 2017, to June 1, 2019, were eligible for inclusion. The main outcome was total score on a childbirth experience questionnaire (range 1.0–4.0, higher score indicates better childbirth experience). An absolute risk difference of 0.10 was considered clinically relevant. Propensity score matching was used to adjust for differences in baseline characteristics between women with and without PNB. The analyses were stratified by spontaneous vs instrumental birth. Subanalyses of the questionnaire's domains (own capacity, professional support, perceived safety, and participation) were performed.ResultsOf 979 participating women, mean age was 32 years. Childbirth experience did not differ between women with and without PNB, either in spontaneous (absolute risk difference of the mean: −0.05, P value 0.36) or in instrumental birth (absolute risk difference of the mean: 0.03, P value 0.61). There were no statistically significant differences between PNB group scores for the separate domains.ConclusionsWomen's childbirth experiences did not differ between birthing people with or without PNB, either in spontaneous or in instrumental births. The clinical implications of our study should be interpreted in light of the pain‐relieving effects of PNB.PNB should be provided on clinical indication, including for individuals with severe labor pain.
Prograding early to middle Jurassic margin, Neuquén Basin: Topset process stratigraphy and morphodynamic sediment partitioning
Authors: Steel Ronald J. , Olariu Cornel , Rossi Valentina M. , Minisini Daniel , Brinkworth Walter , Loss Laura M. , Giunta David , Vocaturo Griselda 
Published: December 2022

AbstractNew Cuyo Group outcrop data complement recently published seismic and well data that detail the progradational character of the Lower‐Middle Jurassic Neuquén Margin (Argentina). The deepwater margin, with shelf topset (Lajas Formation), slope break and deepwater slope to basin‐floor deposits (Los Molles Formation), prograded northward and westward as large‐scale clinoforms (250–500 m high) for 120 km, during 13 My, supplied by sediment mainly from the North Patagonian Massif. The studied Lajas Formation topsets are themselves progradational, with a 500 m‐thick vertical succession of subaqueous delta, shoreface with associated tidal flat, mouth bar, fluvio‐tidal channel and alluvial plain deposits. This pattern is confirmed by facies analysis in five areas of outcrops and well data but is interrupted by frequent marine transgressions that add a short‐term cyclicity to the succession. A new paleogeographic map suggests previous disagreements on process stratigraphy are due to shoreline/paralic strike variability and to increased basinal process impact as the topset/shelf widened. A marked feature of each Lajas topset sequence is a differential partitioning of sand and mud, though not with a simple proximal to distal grain‐size reduction. The sand‐prone outer shelf passes landward to a channelized muddy shoreline environment, and then to a mixed sandy and muddy channelized coastal and alluvial plain. This type of partitioning, important for the characterization and prediction of reservoir quality, can also be recognized on seismic and well log data.
Impact of local predisposing/precipitating factors and systemic drivers on peri‐implant diseases
Authors: Monje Alberto , Kan Joseph Y. , Borgnakke Wenche 
Published: December 2022

AbstractBackgroundStrong evidence suggests the infectious nature of peri‐implant diseases occurring in susceptible hosts. Epidemiological reports, though, indicate that peri‐implantitis is a site‐specific entity. Hence, the significance of local factors that may predispose/precipitate plaque accumulation and the impact of systemic drivers that alter the immune response are relevant in the prevention and management of peri‐implant disorders.PurposeThe purpose of the present review is to shed light on the significance of local and systemic factors on peri‐implant diseases, making special emphasis on the associations with peri‐implantitis.MethodsThe biologic plausibility and supporting evidence aiming at providing a concluding remark were explored in the recent scientific literature for local predisposing/precipitating factors and systemic drivers related to peri‐implant diseases.ResultsLocal predisposing factors such as soft tissue characteristics, implant position and prosthetic design proved being strongly associated with the occurrence of peri‐implant diseases. Hard tissue characteristics, however, failed to demonstrate having a direct association with peri‐implant diseases. Robust data points toward the strong link between residual sub‐mucosal cement and peri‐implant diseases, while limited data suggests the impact of residual sub‐mucosal floss and peri‐implantitis. Systemic drivers/habits such as hyperglycemia and smoking showed a strong negative impact on peri‐implantitis. However, there is insufficient evidence to claim for any link between metabolic syndrome, atherosclerotic cardiovascular disease, and obesity and peri‐implant diseases.ConclusionLocal predisposing/precipitating factors and systemic drivers may increase the risk of peri‐implant diseases. Therefore, comprehensive anamnesis of the patients, educational/motivational programs and exhaustive prosthetically‐driven treatment planning must be fostered aiming at reducing the rate of biological complications in implant dentistry.
Visual outcomes after anterior temporal lobectomy and transsylvian selective amygdalohippocampectomy: A quantitative comparison of clinical and diffusion data
Authors: Pruckner Philip , Nenning Karl‐Heinz , Fischmeister Florian Ph.S , Yildirim Mehmet‐Salih , Schwarz Michelle , Reitner Andreas , Aull‐Watschinger Susanne , Koren Johannes , Baumgartner Christoph , Prayer Daniela , Rössler Karl , Dorfer Christian , Czech Thomas , Pataraia Ekaterina , Kasprian Gregor , Bonelli Silvia 
Published: December 2022

AbstractObjectiveAnterior temporal lobectomy (ATL) and transsylvian selective amygdalohippocampectomy (tsSAHE) are effective treatment strategies for intractable temporal lobe epilepsy but may cause visual field deficits (VFDs) by damaging the optic radiation (OpR). Due to the OpR's considerable variability and because it is indistinguishable from surrounding tissue without further technical guidance, it is highly vulnerable to iatrogenic injury. This imaging study uses a multimodal approach to assess visual outcomes after epilepsy surgery.MethodsWe studied 62 patients who underwent ATL (n = 32) or tsSAHE (n = 30). Analysis of visual outcomes was conducted in four steps, including the assessment of (1) perimetry outcome (VFD incidence/extent, n = 44/40), (2) volumetric OpR tractography damage (n = 55), and the (3) relation of volumetric OpR tractography damage and perimetry outcome (n = 35). Furthermore, (4) fixel‐based analysis (FBA) was performed to assess micro‐ and macrostructural changes within the OpR following surgery (n = 36).ResultsAltogether, 56% of all patients had postoperative VFDs (78.9% after ATL, 36.36% after tsSAHE, p = .011). VFDs and OpR tractography damage tended to be more severe within the ATL group (ATL vs. tsSAHE, integrity of contralateral upper quadrant: 65% vs. 97%, p = .002; OpR tractography damage: 69.2 mm3 vs. 3.8 mm3, p = .002). Volumetric OpR tractography damage could reliably predict VFD incidence (86% sensitivity, 78% specificity) and could significantly explain VFD extent (R2 = .47, p = .0001). FBA revealed a more widespread decline of fibre cross‐section within the ATL group.SignificanceIn the context of controversial visual outcomes following epilepsy surgery, this study provides clinical as well as neuroimaging evidence for a higher risk and greater severity of postoperative VFDs after ATL compared to tsSAHE. Volumetric OpR tractography damage is a feasible parameter to reliably predict this morbidity in both treatment groups and may ultimately support personalized planning of surgical candidates. Advanced diffusion analysis tools such as FBA offer a structural explanation of surgically induced visual pathway damage, allowing noninvasive quantification and visualization of micro‐ and macrostructural tract affection.
The future of grand challenges research: Retiring a hopeful concept and endorsing research principles
Authors: Seelos Christian , Mair Johanna , Traeger Charlotte 
Published: December 2022

AbstractEditorial notes in leading management journals have urged scholars to address Grand Challenges (GC) as an opportunity for producing knowledge that matters for society. This review explores whether current conceptualizations of GC support a productive path for management and organizational scholarship by guiding empirical inquiry, facilitating cumulative theory development, and informing practice. We systematically examine scholarly articles, calls for papers, and editorial notes published in management journals for consistency in how researchers use and define the concept of GC and the scope of associated phenomena and attributes. We find three prominent conceptual architectures in use: discursive, family resemblance, and phenomenon driven. The variety and incoherence of current uses of the GC concept and the lack of efforts to improve its analytical competence lead us to suggest its retirement. Instead, we propose building on the enthusiasm around GC research and using GC as a term to define research principles that collectively help align research efforts and improve theoretical development and practice. The principles we propose capture a genuine origin story for management research on GC.
‘They tell us after they've decided things’: A cross‐country analysis of unions and digitalisation in retail
Authors: Payne Jonathan , Lloyd Caroline , Jose Secki P. 
Published: December 2022

AbstractThe role of trade unions in the social shaping of digital technologies is a vital question for research, public policy and social justice. This article draws on interviews with two unions in the grocery retail sector in the United Kingdom and Norway, and examines their involvement in technology decisions, and whether they can shape better outcomes for workers. By comparing a ‘neo‐liberal’ economy and a ‘Nordic welfare state’, the article considers whether stronger institutional power and regulatory supports in Norway provide for greater influence in a sector regarded as challenging for unions. The findings indicate relatively few country differences and help shed light on the factors that enable and constrain unions’ role in digitalisation.
Beyond bulevirtide: Alternative therapeutic options for the management of hepatitis delta virus
Authors: Asselah Tarik 
Published: December 2022

AbstractHepatitis delta virus (HDV) is a small RNA virus which needs Hepatitis B Surface Antigen for its envelope, for entry into hepatocytes and secretion. HDV chronic infection affects around 12 million people worldwide. HDV infection is believed to be the most severe form of viral hepatitis, with a high risk of developing cirrhosis and hepatocellular carcinoma. Pegylated interferons has been used and recommended by guidelines, although not approved, with low efficacy and poor tolerability. Bulevirtide (entry inhibitor) has been recently conditionally approved by the European Medicines Agency. These treatments have many advantages, but they have also limitations since there are non‐responders to these previous therapies. There is an urgent need to develop new drugs. In this article, we review antiviral treatments under development for HDV chronic infection (except bulevirtide reviewed in a specific article), including those in the HBV cure programme, outlining their respective mechanisms‐of‐action.
Serum HBV RNA is associated with liver fibrosis regression in HBeAg‐positive chronic hepatitis B patients treated with nucleos(t)ide analogues
Authors: Bian Dandan , Zhao Jing , Liao Hao , Wang Yang , Ren Yan , Jiang Yingying , Liu Shuang , Chen Xinyue , Hu Zhongjie , Duan Zhongping , Lu Fengmin , Zheng Sujun 
Published: December 2022

AbstractNoninvasive methods for assessing hepatic fibrosis are clinically necessary. This study aims to explore HBV markers correlated with liver fibrosis and capable of diagnosing significant fibrosis and predicting fibrosis regression. Seventy‐four HBeAg‐positive chronic hepatitis B (CHB) patients were enrolled and started on entecavir or adefovir therapy. Serum HBV RNA, HBV DNA, HBsAg and hepatitis B core‐related antigen (HBcrAg) levels were measured at baseline and during treatment. Liver fibrosis was assessed at baseline and month 60 by liver biopsy. Fibrosis regression was defined as Ishak fibrosis score decreased ≥1‐point. At baseline, HBsAg, HBcrAg and HBV RNA levels had a stronger correlation with Ishak fibrosis score (r = −.441, p = .002; r = −.469, p = .001; r = −.398, p = .001) than APRI and FIB‐4 (r = .321 p = .006; r = .371, p = .001). HBsAg >4 log10 IU/ml plus HBcrAg >7 log10 IU/ml or HBsAg >4 log10 IU/ml plus HBV RNA >5 log10 copies/ml exhibited the same excellent diagnostic ability for significant fibrosis with the AUROC of 0.857. After 60 months of antiviral treatment, 66.7% of patients who suffered significant fibrosis at baseline achieved fibrosis regression, and an HBV RNA decline from baseline to month 6 greater than 0.63 log10 copies/ml could predict the fibrosis regression at month 60. In conclusion, serum HBsAg, HBcrAg and HBV RNA are potential markers for predicting significant liver fibrosis. HBV RNA measurement would be particularly useful for monitoring hepatic fibrosis changes in HBeAg‐positive CHB patients.
Effects of jaw movement in bimaxillary orthognathic surgery on the upper airway: Computational fluid dynamics analysis
Authors: Nomura Tsutomu , Sasaki Au , Fujimoto Mai , Mano Mikiko , Suda Naoto , Kondo Kenji 
Published: December 2022

AbstractMaxillomandibular repositioning in orthognathic surgeries has both morphologic and functional effects. These surgeries are thought to change the pharyngeal space and cause obstructive sleep apnoea syndrome, however. The primary purpose of this study is to evaluate the effects of jaw movement in bimaxillary orthognathic surgery on airway function and to identify the morphometric factors that can predict postoperative airway function. The subjects were 11 males and 12 females who had undergone orthognathic surgeries of the maxilla and mandible. The results of cephalometric analysis, cross‐sectional area of the pharynx (CSA), pharyngeal volume and computational fluid dynamics (CFD) were compared. The CSA of the nasal (CSA1), total volume and total nasal volume decreased after surgery with statistical significance. Velocity at the oropharyngeal space (V2) increased after surgery with statistical significance. V2, CSA of the oropharyngeal space (CSA2) and PV were correlated with the horizontal posterior movement of point B, point Menton and overjet. V2 and CSA2 were correlated with SNB before and after surgery in all 46 analyses. Changes in pharyngeal airflow were more affected by pressure drop in the pharyngeal space (ΔPp) than by pressure drop in the nasal space (ΔPn). The relationship between the actual amount of change in the cephalometric reference point and the airway function is evident. CFD may thus be very useful as morphological analysis in preoperative treatment decision making.