bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatic Detection and Segmentation of Brain Hemorrhage based on
Improved U-Net Model
Authors: Phan Thuong-Cang , Phan Anh-Cang 
Published: September 2023

Introduction::
Brain hemorrhage is one of the leading causes of death due to the sudden rupture of a blood vessel in the brain, resulting in bleeding in the brain
parenchyma. The early detection and segmentation of brain damage are extremely important for prompt treatment.

Methods::
Some previous studies focused on localizing cerebral hemorrhage based on bounding boxes without specifying specific damage regions. However,
in practice, doctors need to detect and segment the hemorrhage area more accurately. In this paper, we propose a method for automatic brain
hemorrhage detection and segmentation using the proposed network models, which are improved from the U-Net by changing its backbone with
typical feature extraction networks, i.e., DenseNet-121, ResNet-50, and MobileNet-V2. The U-Net architecture has many outstanding advantages.

Results::
It does not need to do too many preprocessing techniques on the original images and it can be trained with a small dataset providing low error
segmentation in medical images. We use the transfer learning approach with the head CT dataset gathered on Kaggle including two classes,
bleeding and non-bleeding.

Conclusion::
Besides, we give some comparison results between the proposed models and the previous works to provide an overview of the suitable model for
cerebral CT images. On the head CT dataset, our proposed models achieve a segmentation accuracy of up to 99%.
Lysosomal Storage Diseases: Natural Products Inducing Autophagy
Authors: Chandarana Chandani , Habshi Tahib , Soni Arun , Acharya Sanjeev 
Published: September 2023

Background:
The link between autophagy and lysosomal function has been wellrecognised
in recent decades; defective autophagy and lysosomal function lead to various disorders,
notably Lysosomal Storage Disorders (LSDs). The malfunction of multiple mechanistic pathways influences
the contribution of LSDs. Different ways are employed in such situations, but one novel approach
could resolve the problem by inducing the autophagic pathway, which aids in maintaining
proper autophagy and lysosomal degradation function.

Methods:
Autophagic Inducer functions on the activation of Transcriptional factor EB (TFEB) and its
mechanism; mTOR Complex Inhibition dependently or independently may repair the malfunction of
the entire mechanism. Finding a potential autophagic inducer is still a work in progress, but targeting
TFEB and mTOR could redefine LSD treatment. The development of experimentally available TFEB
modulators could enhance autophagic flux promote lysosomal function and increase lysosomal biogenesis
and can be a promising technique for treating illnesses caused by ALP dysfunction, such as
lysosomal storage disorder.

Results:
MTORC1 suppression causes TFEB to be transported to the nucleus and transcription of multiple
genes involved in the formation of autophagosomes and lysosomes, indicating that MTORC1 has
positive effects in treating lysosomal storage diseases such as Pompe disease, Batton disease, Fabry
disease, etc. thus modulating autophagy attenuates the above condition.

Conclusion:
This review comprises autophagy and lysosome association, and their malfunction leads
to various lysosomal diseases. Several natural products are also discussed, which can be possible
treatment options.
Evolution of Nuvoton Microcontroller-based Education Board
Authors: Elp Hudaverdi Emin , Inan Remzi 
Published: September 2023

Background::
The novel coronavirus pandemic has not only affected people's health. The
pandemic has also affected their social life and work. For all the reasons mentioned, international
trade has suffered and is still in the process of recovery.

Objective::
Especially in the semiconductor industry, many manufacturers postponed their deliveries
to future periods and this triggered the chip crisis. Many hightech industries, including the automotive
industry, were deeply affected by the consequences of the crisis, with factories halting or slowing
down production. Despite the shortage of chip stocks, Nuvoton has a large amount of Microcontroller
Units (MCUs), but due to the shortage of resources, education and libraries, software developers
have not been able to integrate their products in a limited time.

Methods::
In this paper, the Nuvoton Education Board has presented 20 common examples for embedded
software developers and beginners.

Results::
The PCB is designed considering all modules connected to separate General Purpose Input
Output (GPIO) pins to make multiple module examples without changing the peripherals and pin
configuration of the MCU. Clock configuration has been simplified and unnecessary details have
been meticulously removed to make the examples easily understandable. Nuvoton NuMaker
M263KI V1.3 was added on the designed PCB.

Conclusion:
The PCB contains almost all the necessary electronics to learn embedded software and
use Nuvoton MCUs in industrial projects. The board is supported with user interfaces and printed
documentation. The codes are explained with command lines to teach users even small details. A
patent application has been filed for the proposed education board.
Analysis of IoT Applications in Highly Precise Agriculture Farming
Authors: N. Latha Reddy , Masila P. Gopinath 
Published: September 2023

Background:
The IoT (Internet of Things) assigns to the capacity of Device-to-Machine (D2M) connections, which is a vital component in the development of the digital economy. IoT integration with a human being enables real-time decision-making in communication, collaboration, and technology analytics. Furthermore, environmental factors impacting plants, such as air humidity, temperature, air quality index, and soil wetness, are not frequently documented, emphasizing the development of a data monitoring system for future agricultural research and development.

Methods:
An IoT-based Intelligent Farming System is proposed. An innovative IoT-based intelligent farming system is developed that integrates real-time data monitoring, machine learning algorithms, and IoT technology to address the identified gaps and challenges.

Result:
In the face of climate change, extreme weather, and environmental constraints, increased food demand must be satisfied. Intelligent agriculture enabled by IoT technology can reduce waste and increase productivity for producers and farmers, from fertilizer use to tractor trips.

Conclusion:
In conclusion, this paper provides insightful and informative commentary on the progress made in technology within the agriculture industry and the challenges that still need to be overcome to achieve optimal outcomes.
Dilema Pemberlakuan PP. No. 78 Tahun 2015 Tentang Pengupahan: Disparitas yang Kian Melebar
Authors: Mahesa Rama , Sabar Kurniawan 
Published: September 2023

This study aims to examine the implementation of wage system in Indonesia based on Law No. 13/2003 and Government Regulation No. 78/2015 on labor conditions in Jabodetabek. The urgency of this study with regard to wage conditions in Indonesia that are still visible lags tend to widen the gap between workers and employers. Itâ€™s a policy study by collecting secondary data and then analyzed into a conclusion and a recommendation. Descriptive qualitative study method used data collection techniques such as: documentation of literature study, discussion and grouping of research object data. The results of the study indicate that the new formula in determining the minimum wage and annual wage increase in Indonesia has been implemented based on PP no. 78 years 2015 which is based on inflation rate and economic growth. The new formula of minimum wage determination is opposed by the workers on the basis of not accommodating the fulfillment of life-worth needs and narrowing the rights of workers in democracy demanding a decent wage increase. Entrepreneurs view PP Wage has not accommodate the condition of UMKMÂ in the implementation of minimum wage that requires the structure of wages and wage scale (SUSU). The Regional Representative Council of the Republic of Indonesia (DPD RI), which is preparing the Wage System Bill, needs field data and facts related to the current wage condition. The important recommendations that can be considered by the DPD RI in the preparation of the Wage System Bill is the refinement of the legislative materials related to the evaluation of the components of Decent Living Needs (KHL) once in five years, the establishment of policies on the implementation of SUSU for UMKM and strengthening the supervisory function in the field of manpower especially in the regions
ضمانات المتهم الحدث في مرحلة المحاكمة دراسة ضوء التطبيقات القضائية
Authors: Qadr Ahmed Ranyar , Mohammed Shareef Ahmed Ramadhan , Sharef Saiwan Jalel 
Published: September 2023

هذا البحث عبارة عن دراسة تحليلية حول متهم الحدث والضمانات التي لديها والمميزات التي يتمتع بها اثناء التحقيق وسريان المحاكمة وإن غاية أو هدف قوانين الإجراءات الجنائية هي تحقيق العدالة في الدعوى الجزائية، وذلك بحماية حقوق أطراف الدعوى وتوفير الضمانات للمتهم سواء حدثاَ أم بالغاً.
حيث هناك الكثير من الضمانات التي يجب أتباعها أثناء سريان المحاكمة للمتهم الحدث، لأن هذه الضمانات تعتبر ذي أهمية فائقة وكبيرة، وتضم هذه الضمانات احترام حق الحدث في حماية خصوصياته، كون الحدث لا يتمتع بالنضج العقلي والادراك الكامل الذي يتمتع به الفرد البالغ ليمكنه من تقدير ما يصدر عنه من سلوك مخالف للقانون، لذا فأنه في حاجة دائمة الى رعاية ومعاملة خاصة تشعره بالأمان والطمأنينة عند مثوله أمام القضاء والاستفادة من محاولة إصلاحه وإعادة تأهيله الى المجتمع .
Вплив на артеріальну жорсткість додавання статинів до антигіпертензивної терапії в пацієнтів з резистентною артеріальною гіпертензією
Authors: Sirenko Y.M. , Rekovets O.L. , Torbas O.O. , Kushnir S.M. , Primak G.F. 
Published: September 2023

Метою цього дослідження була оцінка артеріальної жорсткості, яка змінилася після додавання статинів до фіксованої комбінованої антигіпертензивної терапії в пацієнтів з резистентною артеріальною гіпертензією. Матеріали та методи. Включено 99 хворих на помірну й тяжку артеріальну гіпертензію без цукрового діабету. Ці пацієнти були розподілені на 2 групи. Першій групі (n = 59) було призначено фіксовану комбінацію антигіпертензивної терапії плюс аторва-статин 20–40 мг/добу. Пацієнти другої групи (n = 40) отримували фіксовану комбінацію антигіпертензивних препаратів без статинів. Серцево-гомілковий судинний індекс (CAVI) визначався до і в кінці періоду спостереження. Проводилися моніторинг офісного артеріального тиску (АТ), добове моніторування артеріального тиску (ДМАТ). Були проведені лабораторні дослідження: загальний аналіз крові, аналіз сечі та біохімічний аналіз крові. Тривалість дослідження становила 6 місяців. Результати. Офісний АТ і показник ДМАТ однаково значно знизилися в обох групах лікування. Рівні загального холестерину (ЗХС) і холестерину ліпопротеїдів низької щільності (ХС ЛПНЩ) значно знизилися в групі аторвастатину на 1,76 ммоль/л (30 %, р < 0,05) і 1,51 ммоль/л (41 %, р < 0,05) відповідно. У групі без терапії аторвастатином не було змін рівня ЗХС і ХС ЛПНЩ. У групі без додавання статинів відзначено достовірне зниження рівня АТ, однак CAVI підвищився до +0,9 од. справа та +1,0 од. зліва. У групі без додавання статинів CAVI після лікування змінився з 7,73 ± 0,17/7,62 ± 0,19 од. до 8,63 ± 0,22/8,62 ± 0,12 од. справа/зліва відповідно (p < 0,05). Це означає, що в групі без додавання статинів через 6 місяців терапії спостерігалося збільшення жорсткості артеріальної стінки за CAVI. У групі з додаванням статину після 6 місяців терапії CAVI не змінився: CAVI справа/зліва становив 8,32 ± 0,16/8,33 ± 0,19 од. на початку і 8,44 ± 0,16/8,24 ± 0,15 од. — після лікування (p > 0,05). Впливу статинотерапії на рівень АТ ми не відзначили. Проте було виявлено кореляційні зв’язки між CAVI та віком, рівнем тригліцеридів до лікування, ХС ЛПНЩ, тривалістю гіпертензії, рівнем глюкози в крові. Висновки. Додавання аторвастатину до фіксованої комбінації антигіпертензивної терапії може запобігти прогресуванню жорсткості артерій у пацієнтів з артеріальною гіпертензією.
Pelaksanaan Inisiasi Menyusu Dini berdasarkan Jenis Persalinan di Indonesia: Analisis SDKI 2017
Authors: Ahmad Fakhrunnisa , Utomo Budi , Ramadhan Noor Aulia 
Published: September 2023

Background: Breast milk that comes out for the first time contains highly nutritious colostrum, has antibody, and very suitable food to consume for new born babies. Immediately after the baby was born, the baby is placed on the mother's breast without any hindrance, so the baby can breastfeed in the first hour and get warmth from the mother's body. Some research suggests that breastfeeding immediately after birth can prevent neonatal and infant death.Objective: This research was conducted to see whether the mother's residence, age, number of children, number of antenatal visits, type of childbirth delivery, and the childbirth assistant's affect the implementation of early breastfeeding.Method: This research will use a cross sectional by using the individual data from IDHS year 2017 with a total data sample of 14341.Results and Discussion: After being analysed using complex sample analysis, the analysis result will show the residence place, number of children, antenatal visits, type of childbirth delivery will become the determined factors from early child breastfeeding. It will be seen that the normal type of delivery allows for early breastfeeding initiation to be 3 times greater than labor with cesarean section after being controlled by variables of residence, number of children, and antenatal visits.Conclusion: Maternal age and birth attendants will not influence the occurrence of early initiation of breastfeeding; type of delivery, residence, number of children, and antenatal visits variables are released to early initiation of breastfeeding Keywords: Breastfeeding initiation; type of delivery; SDKI 2017
Hubungan antara Stres dan Pola Menstruasi pada Remaja Perempuan Sekolah Menengah Atas Negeri di Kota Yogyakarta
Authors: Saneba Hardiknas Steven , Pangastuti Nuring , Prawitasari Shinta 
Published: September 2023

Latar Belakang: Perubahan pada siklus menstruasi dapat disebabkan oleh kelainan primer maupun sekunder pada organ reproduksi. Stres merupakan salah satu penyebab gangguan sekunder pada sistem reproduksi yang dapat menyebabkan functional hypothalamic amenorrhea (FHA), premature ovarian failure (POF), atau perubahan pada karakteristik siklus menstruasi melalui penekanan pada aksis hipotalamus-pituitari-gonad. Beberapa penelitian mendukung pernyataan ini, namun masih terdapat variasi untuk mengidentifikasi ambang batas dimana tingkat stres dapat mengganggu siklus menstruasi.Tujuan: Mengetahui bagaimana hubungan antara stres dengan gangguan menstruasi pada remaja perempuan Sekolah Menengah Atas (SMA) Negeri di kota Yogyakarta.Metode: Metode penelitian ini adalah Cross-sectional. Subyek penelitian terdiri dari remaja perempuan kelas X dan XI SMA Negeri di kota Yogyakarta yang berusia 15-18 tahun dan data-data diperoleh melalui pengisian kuesioner online. Gangguan menstruasi ditentukan berdasarkan kriteria The International Federation of Gynecology and Obstetrics (FIGO) abnormal uterine bleeding (AUB) system-1 tahun 2018 yang direvisi. Tingkat stres diukur melalui skor Perceived Stress Scale (PSS) dan variabel luar yang dievaluasi adalah indeks massa tubuh dan aktivitas fisik dengan intensitas sedang. Analisis data menggunakan uji Chi Square dan analisis regresi logistik.Hasil: Dari total 596 responder yang memenuhi kriteria inklusi, prevalensi tingkat stres tinggi sebesar 70,47% dan gangguan menstruasi sebesar 43,29%. Analisis bivariat menunjukkan tidak terdapat hubungan yang bermakna antara tingkat stres tinggi (p= 0,830; RP 1,022), indeks massa tubuh (p= 0,542; RP 1,094), maupun aktivitas fisik intensitas sedang (p= 0,717; RP 1,045) terhadap gangguan menstruasi. Hasil yang sama ditunjukkan melalui analisis multivariat.Kesimpulan: Tingkat stres tinggi ditemukan pada sebagian besar remaja perempuan di kota Yogyakarta, namun tidak terdapat hubungan antara tingkat stres terhadap gangguan menstruasi.Kata kunci: gangguan menstruasi, stres, remaja perempuan
Evaluation of the Key Performance Indicators of the In Vitro Fertilization (IVF) Program at the Permata Hati Clinic, Dr. Sardjito in 2019-2020
Authors: Prabowo Bayu Rizky , Widad Shofwal , Trirahmanto Addin 
Published: September 2023

Background: One of the efforts that can be done to overcome infertility is In Vitro Fertilization (IVF) or the IVF process is a process in which the egg is fertilized by sperm outside the body. Where in the In Vitro Fertilization effort, hormone stimulation is carried out, in principle, is an effort to add a number of hormones from the outside (exogenous hormone) which functions as control of the reproductive process, so that the reproductive cycle can be accelerated or can be carried out outside its natural environment. Given the many risks that arise, a measurement is needed to determine the success rate of the IVF program itself. Research Performance indicator or key performance indicator (KPI) is a type of performance measurement of any process, whether in biomedical or non-biomedical fields, may be subject to inherent deviations from the optimum limit or from the set limit.Objective: Conduct an evaluation with Key Performance Indicators on In Vitro Fertilization (IVF) patients at the Permata Hati Clinic, Dr. Sardjito.Method: This research is a descriptive observation because the researcher only observes without treating the object to be studied. This research was conducted at Dr. RSUP. Sardjito because RSUP Dr. Sardjito owns the Permata Hati infertility clinic, which provides patients with IVF (in vitro fertilization or IVF) procedures. Data collection was carried out especially in the medical record section which was carried out in January 2019 - January 2020.Results and Discussion: The variables of ICSI damage level, normal ICSI fertilization rate, normal IVF success rate, IVF fertilization failure rate, blastocyst cryosurvival rate, and implantation level (cleavage stage) have not been able to meet the key performance indicators. , and the implantation rate (blastocyst stage) met the key performance indicatorsConclusion: Permata Hati Clinic Performance RSUP Dr. Sardjito is still under competency and aspirational performance based on key performance indicators. Keywords: Key Performace Indicator; In Vitro Fertilization; Assisted reproductive technique
Producción de contenidos audiovisuales accesibles en tiempos de pandemia. El caso del Programa de Comunicación Institucional de la UNPA UACO
Authors: Ksybala Nadia Carolina 
Published: September 2023

El contexto pandémico vino a profundizar las desigualdades subyacentes en una sociedad que ya antes de la existencia del COVID-19 se presentaba para unos pocos. Una de las consecuencias en el devenir cotidiano de la comunidad derivadas de este vivir al sur de la cuarentena, como reza Boaventura de Sousa Santos, se relaciona con la falta de acceso a la información que desde diversos espacios se ha procurado brindar a la sociedad. En dicha coyuntura, y especialmente en lo que respecta al rol de la Universidad en tanto generadora y transmisora de conocimiento y defensora de la condición humana, se busca analizar la implementación de las herramientas de accesibilidad comunicacional en las producciones audiovisuales elaboradas en la Unidad Académica Caleta Olivia de la Universidad Nacional de la Patagonia Austral, a partir de los discursos que definen a esta última como una institución abierta e inclusiva.
Este trabajo de investigación expone los resultados obtenidos a partir del análisis de las prácticas comunicativas multimediales partiendo como hito de la promulgación de la Ley N°26.522 de Servicios de Comunicación Audiovisual (2009). Para esto se siguió una metodología cualitativa que combina entrevistas con el relevamiento de documentos y normativas que regulan la accesibilidad comunicacional, en el marco de un contexto institucional que se inscribe en las políticas inclusivas de accesibilidad académica. Ello permite advertir la posible pregnancia del modelo médico-rehabilitador de aproximación al fenómeno de la discapacidad y de una mirada capacitista, que reduce, margina y anula, a la hora de garantizar el acceso a la información, máxime en tiempos donde la misma se ha vuelto vital.
FAKTOR-FAKTOR YANG MEMPENGARUHI FINANCIAL DISTRESS
Authors: Budiarjo Christopher Imanuel , Rahayuningsih Deasy Ariyanti 
Published: September 2023

Tujuan penelitian ini adalah untuk memperoleh bukti secara empiris mengenai pengaruh dari kepemilikan manajerial, kepemilikan institusional, proporsi komisaris independen, intellectual capital, profitabilitas, likuiditas, aktivitas, dan solvabilitas. Variabel dependen pada penelitian ini adalah financial distress yang diukur menggunakan model Altman Z-Score. Objek penelitian yang digunakan pada penelitian ini adalah perusahaan manufaktur yang konsisten terdaftar di Bursa Efek Indonesia (BEI) periode 2019-2021. Metode pengambilan sampel yang digunakan pada penelitian ini adalah purposive sampling yang menghasilkan 143 perusahaan dengan total data 429 data. Pengujian hipotesis pada penelitian ini menggunakan analisis regresi linear berganda. Hasil penelitian yang diperoleh berdasarkan pengujian pada penelitian ini menunjukkan bahwa intellectual capital, profitabilitas, rasio aktivitas, dan solvabilitas berpengaruh negatif terhadap financial distress. Sedangkan kepemilikan manajerial, kepemilikan institusional, proporsi komisaris independen, dan likuiditas tidak berpengaruh terhadap financial distress. Hal ini disebabkan tingkat pengawasan yang tidak efektif dari manajerial dan institusi dan proporsi komisaris independen yang ada hanya untuk memenuhi regulasi perusahaan saja. Selain itu, dibutuhkan waktu yang lama bagi perusahaan untuk mengubah aset menjadi kas untuk melunasi kewajiban jangka pendek perusahaan.
Pengaruh Motivasi Kerja, Kepemimpinan Dan Lingkungan Kerja Terhadap Kinerja Pegawai Negeri Sipil Pada Saat Pandemi Covid 19 Di Kecamatan Gunung Agung
Authors: Japlani Ardiansyah , Suryadi Suryadi , Lianti Novi 
Published: September 2023

The basic problem is the lack of human qualities that can hinder the growth anddevelopment of the national economy. Lack of humanity will also be a stumbling block in theera of globalization, because the era of globalization is a time of quality competition. If theIndonesian people want to participate in the global stage, then the first step is that whatneeds to be done is to organize their personality, both mentally, spiritually, creatively,morally and responsibly. the quality of human resources related to performance. This studyaims to determine 1) To find out whether the motivation variable has an effect on employeeperformance. 2) To find out whether the variable of Leadership on Employee Performance.3) To find out whether the work environment variable on employee performance. 4) Todetermine the effect of the variables of Motivation, Leadership, Work Environment, togetheron Employee Performance. The survey method was chosen as the primary data source. Thesurvey method focuses on collecting data from respondents who have certain information, thus enabling researchers to solve problems. Data collection was carried out using aquestionnaire or questionnaire instrument. In this study, the population is consumers whouse telkom products. The sampling technique uses accidental sampling. The population inthis study are all employees who work at the Gunung Agung sub-district office, namely 57employees and temporary employees. The results showed that 1) there was a positive andsignificant influence between motivation on employee performance 2) there was a positiveand significant influence between leadership on employee performance. 3) there is apositive and significant influence between the work environment on employee performance.4) there is a positive and significant influence between motivation, leadership and workenvironment on employee performance