bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Relation Between the Students’ Knowledge on Sexual Health, Opinions on Sexual Myths and Level of Health Literacy
Authors: KOCAAY Funda , ALTINTAŞ Hilal Melis 
Published: September 2023

Introduction: From the public health perspective, young people are considered as a priority group in terms of sexually transmitted diseases and sexual habits. Sexual dimension among adolescents and young adults can be influenced by their overall and sexual health due to its impact on intellectual growth and development and their level of knowledge can significantly affect their reproductive health. The study aims to measure university students’ health literacy, sexual health knowledge and sexual myths and in this way explore the relationship between these variables and among various demographic variables.
Materials and Methods: The sample of the study is comprised of 559 female and 282 male university students. In the first part, demographic information scale, in the second part sexual health knowledge test, in the third part sexual myths scale, in the fourth part health literacy in Turkey scale were implemented.
Results: In the analysis across the sexes, it was revealed that males have more sexual myths than females (p
O financiamento das cooperativas. Dificuldades e alternativas
Authors: Meira Deolinda 
Published: September 2023

El fin mutualista de las cooperativas y la necesidad de cumplir los principios cooperativos pueden dificultar su financiación tanto interna como externa. La autofinanciación de las cooperativas se enfrenta a dificultades como la variabilidad del capital social, la no relación entre una mayor participación en el capital y los derechos del socio, la rigidez del régimen de transmisión de los títulos de capital, el régimen de irreparabilidad de las reservas, los límites en las operaciones con terceros, el régimen jurídico de la cuota de ingreso. En cuanto a la financiación externa, destaca el escaso atractivo de los títulos y obligaciones de inversión, dados los límites impuestos a la participación de los suscriptores en el gobierno de la cooperativa y los límites a las condiciones de remuneración. La figura de los miembros inversores está sujeta a límites en términos de elegibilidad para los órganos, número máximo de votos y contribuciones financieras, lo que puede debilitar el atractivo de esta figura.
Recibido: 4 mayo 2023Aceptado: 6 junio 2023
Empreendedorismo social no setor cooperativo em Portugal: um estudo exploratório
Authors: Bernardino Susana , Santos J. Freitas 
Published: September 2023

La aparición de nuevos desafíos en las sociedades modernas ha creado en las organizaciones sociales la necesidad de crear nuevos modelos de respuesta, incluyendo el sector cooperativo. A través del método de estudio de caso, este artículo pretende demonstrar la aplicación de un comportamiento socialmente emprendedor a la resolución de un problema social concreto identificado en la comunidad, cuya repuesta presenta la forma jurídica de cooperativa. Además, pretende demonstrar la relevancia que un enfoque socialmente empresarial es capaz de tener en la capacidad de creación de valor para la comunidade. La análisis del estudio de caso ha permitido identificar presencia de elementos de comportamiento empresarial, como la innovación, la proactividad, la asunción de riesgos, la autonomía y la competitividad agresiva, que resultan relevantes para el diseño e implementación de una respuesta del sector cooperativo con impacto social sostenible.
Recibido: 5 mayo 2023Aceptado: 8 junio 2023
ESTÁGIO OBRIGATÓRIO NA EDUCAÇÃO INFANTIL: LIMITES E POSSIBILIDADES NA FORMAÇÃO INICIAL EM EDUCAÇÃO FÍSICA
Authors: Biella Felipe Gomes , Cardoso Ana Lúcia 
Published: September 2023

A pesquisa tem como objetivo apresentar as facilidades e dificuldades encontradas na realização do estágio obrigatório da Educação Física na Educação Infantil. A pesquisa foi de campo, e foi proposto um questionário aos acadêmicos da 7ª e 8ª fase do curso de Licenciatura em Educação Física. Concluímos que os acadêmicos perceberam mais facilidades do que dificuldades na realização do estágio obrigatório da educação física na educação infantil, pois se apropriaram da proposta crítico emancipatória que subsidia o planejamento e a atuação docente, desenvolvidos ao longo do estágio. Evidenciando-se que o curso de Educação Física vem concretizando o seu projeto pedagógico.
Rancang Bangun Sistem Otomatisasi Pergantian Air Kolam Budidaya Ikan Nila Berdasarkan Parameter Kondisi Air Menggunakan Nodemcu ESP8266
Authors: Anjali Cintya Nada , Lutfi Moch 
Published: September 2023

Water quality in ponds is a physical factor that influences tilapia cultivation. In general, tilapia can grow at a degree of acidity (pH) 5-9 with a maximum air turbidity of 50NTU. Cases of tilapia death in GIP Housing Martopuro Village often occur due to a lack of attention in maintaining the quality of pond water. So with the case study method that aims to solve these problems a system is designed that can monitor water quality and automatic water changes based on water condition parameters through the "Nila Fish Care" application, the application is available on Google Playstore. The results of testing the average water pH is 6.37 and the average value of water turbidity is 35.96. With this system, that it can assist tilapia farmers in monitoring air quality remotely using an application and changing water automatically without human power
Rainbow Connection Number of Double Quadrilateral Snake Graph
Authors: Yuniarti Ervie Yuniarti Astika Mustafaputri , Nurwahyu Budi , Massalesse Jusmawati 
Published: September 2023

Let graph G = be a non trivial connected graph. A graph G with edge coloring is called a rainbow connection, if for every pair of vertices on a path has a different color. The rainbow connection number denoted by is the minimum color needed to make graph G rainbow connection. In this study, we will determine the rainbow connection number of double quadrilateral snake graph and alternate double quadrilateral snake graph. The research results show that while if and if
Explorando a Percepção Socioambiental dos Alunos sobre a Bacia Hidrográfica do Rio Tubarão e Complexo Lagunar
Authors: Flores Nícolas 
Published: September 2023

Este plano de aula foi desenvolvido para alunos do 2º ano do Ensino Médio, com o objetivo de compreender a percepção dos estudantes sobre as mudanças na Bacia Hidrográfica do Rio Tubarão e Complexo Lagunar, bem como promover uma consciência socioambiental mais profunda. A metodologia engloba 12 aulas, com foco em estratégias ativas como Trabalho em Pequenos Grupos, pesquisa bibliográfica, discussões, questionamentos e mapas conceituais.
Os objetivos específicos incluem avaliar a percepção socioambiental dos alunos, identificar fontes de informação sobre a crise socioambiental, analisar relações entre essa crise e a Bacia Hidrográfica, compreender o papel da escola e sociedade na sustentabilidade e gerar aspectos para a Educação Ambiental. A avaliação será formativa e contínua, levando em consideração a participação, comportamento, entrega de trabalhos individuais e em grupo, criatividade e avaliação escrita.
Serão utilizados recursos como laboratório de informática ou biblioteca, além de materiais recicláveis para a construção de maquetes. A estrutura do plano busca fomentar o pensamento crítico, a interação e a participação ativa dos alunos, permitindo-lhes explorar e compreender as complexidades da Bacia Hidrográfica do Rio Tubarão e Complexo Lagunar. As referências utilizadas incluem a Base Nacional Comum Curricular (BNCC) e obras que respaldam as estratégias didáticas propostas.
Preparedness of Nigerian Medical Students for an Era of Precision Medicine – A Cross-sectional Survey in Lagos, Nigeria.
Authors: Ogamba Chibuzor F. , Roberts Alero A. , Ajudua Sharon C. , Akinwale Mosopefoluwa O. , Jeje Fuhad M. , Ibe Festus O. , Afolayan Moses M. , Kuyinu Yetunde A. 
Published: September 2023

Abstract

Background
The increasing advances in precision medicine in Nigeria suggest improving genomics education and competency among healthcare practitioners to facilitate clinical translation. Due to the scarcity of research in this area, this study aimed to assess Nigerian medical students' preparedness to integrate precision medicine into their clinical practice.
Methods
This was an institution-based cross-sectional study of 300 medicine and surgery students in their clinical years attending the two fully accredited colleges of medicine in Lagos, Nigeria, between April and October 2022 using an adapted tool administered via Google Forms. The survey assessed awareness, perceived knowledge, ability and attitudes towards precision medicine, ethical concerns, and perceptions about their education in precision medicine. Multivariate linear regression models were used to assess factors associated with students’ perceived knowledge, ability and attitudes.
Results
Awareness of genomic medicine terminology was high (92.0%). Respondents had above-average median perceived knowledge, ability and attitude scores. Higher level in medical school was independently associated with lower perceived knowledge (ptrend = 0.003) and ability (ptrend = 0.005) scores, and perceived knowledge score was independently associated with a higher perceived ability score (β: 0.76 95%CI: 0.67, 0.84; p<0.001). Attitude scores significantly increased with increasing medical school year (ptrend = 0.04). The respondents mostly indicated concerns about government and corporate bodies' misuse of genomic data (35.7%) and the widening of socioeconomic disparities (34.0%). Although 65.0% of the respondents thought it important to learn about precision medicine, only 11.3% felt that their education had adequately prepared them for precision medicine, knew who to ask questions regarding genomic testing (10.7%) and felt their professors had encouraged the use of precision medicine (10.3%).
Conclusion
Our findings highlight gaps in preparedness for precision medicine and a need to improve precision medicine education among Nigerian medical students.
Confusion and contamination of 8.2 ka cold climate records by the Storegga tsunami
Authors: Bondevik Stein , Risebrobakken Bjørg , Gibbons Steven , Rasmussen Tine , Løvholt Finn 
Published: September 2023

Abstract
Since the end of the last ice age, no cold snap rivals the one dated to 8200 years ago. Its oceanic response has been reconstructed in part from sediments in the Norwegian Sea and North Sea. Here we show that these sediments have been reworked by currents generated by the Storegga tsunami, dated to the coldest decades of the 8.2 ka event. From a new simulation of the Storegga tsunami we calculated the maximum flow velocity to be 2–5 m/s on the shelf offshore western Norway and in the shallower parts of the North Sea, and up to about 1 m/s down to a water depth of 1000 m. We re-investigated sediment core MD95-2011, from which a large and abrupt 8.2 ka cooling had been inferred, and found the cold-water foraminifera to be recycled and 11,000 years of age. Oxygen isotopes of the recycled foraminifera and the content of sand grains, thought to be dropped from ice bergs, might have led to an interpretation of a too large and dramatic climate cooling. Our simulations imply that large parts of the sea floor in the North Sea and Norwegian Sea might have been reworked by currents during the Storegga tsunami.
NAPE-PLD in the ventral tegmental area regulates reward events, feeding and energy homeostasis.
Authors: Castel Julien , Li Guangping , Oriane Onimus , Leishman Emma , Cani Patrice D. , Bradshaw Heather , Mackie Ken , Everard Amandine , Luquet Serge , Gangarossa Giuseppe 
Published: September 2023

Abstract
The N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) catalyzes the production of N-acylethanolamines (NAEs), a family of endogenous bioactive lipids, which are involved in various biological processes ranging from neuronal functions to energy homeostasis and feeding behaviors. Reward-dependent behaviors depend on dopamine (DA) transmission between the ventral tegmental area (VTA) and the nucleus accumbens (NAc), which conveys reward-values and scales reinforced behaviors. However, whether and how NAPE-PLD may contribute to the regulation of feeding and reward-dependent behaviors has not yet been investigated. This biological question is of paramount importance since NAEs are altered in obesity and metabolic disorders.
Here, we show that transcriptomic meta-analysis highlights a potential role for NAPE-PLD within the VTA®NAc circuit. Using brain-specific invalidation approaches, we report that the integrity of NAPE-PLD is required for the proper homeostasis of NAEs within the midbrain VTA and it affects food-reward behaviors. Moreover, region-specific knock-down of NAPE-PLD in the VTA enhanced food-reward seeking and reinforced behaviors, which were associated with increased in vivo DA release dynamics in response to both food and non-food-related rewards together with heightened tropism towards food consumption. Furthermore, midbrain knock-down of NAPE-PLD, which increased energy expenditure and adapted nutrient partitioning, elicited a relative protection against high-fat diet-mediated body fat gain and obesity-associated metabolic features.
In conclusion, these findings reveal a new key role of VTA NAPE-PLD in shaping DA-dependent events, feeding behaviors and energy homeostasis, thus providing new insights on the regulation of body metabolism.
Modification of AJCC TNM staging for intrahepatic cholangiocarcinoma with hepatolithiasis: a multi-institutional retrospective study
Authors: He Gui-Xiang , Liao Cheng-Yu , Lai Jian-Lin , Wu Di-Hang , Hu Jian-Fei , Li Ge , Wang Liang , Lin Tian-Sheng , Tian Yi-Feng , Huang Long , Chen Shi 
Published: September 2023

Abstract
Background
Intrahepatic cholangiocarcinoma (ICC) with stones has a worse long-term prognosis than without stones. The stone factor is not considered in the American Joint Committee on Cancer (AJCC) TNM staging system 8th edition. This research aimed to determine whether the presence of stones was associated with T, N, and M staging and to develop a revised staging approach for a more precise staging of ICC patients who also presented with stones.
Methods
625 ICC patients who had radical resection at three tertiary institutions in Fujian Province, China, between 2012 and 2022 were retrospectively evaluated, and were divided into stone (n = 270) and non-stone groups (n = 355) based on whether combined with hepatolithiasis. In the stone group, overall survival (OS) data was used to develop a modified AJCC staging system called the hepatolithiasis TNM staging system (hlTNM). Both hlTNM and 8th edition AJCC staging were evaluated for their prognostic value in stone group through three-items multivariate analyses and estimated area under ROC curve (AUC).
Results
Postoperative survival was worse in stone group at the same TNM stage. Three-items multivariate analyses illustrated that hlTNM staging was more appropriate for prognostic assessment. In stone group, hlTNM staging system (AUC = 0.892) outperformed the AJCC staging system (AUC = 0.872) in predicting the 3-year OS. hlTNM staging method regularly outperformed the AJCC staging approach regarding time-dependent ROC curves, demonstrating more precise prognostic stratification.
Conclusion
hlTNM staging is more effective in directing physicians’ management of ICC patients with stones and increases the accuracy of OS prediction.
Leisure Activities of Adolescents - Associations with Well-Being and Parental Leisure Engagement
Authors: Wanka Friederike , Vogel Mandy , Grafe Nico , Aßmann Manuela , Kiess Wieland , Poulain Tanja 
Published: September 2023

Abstract
Background
Leisure activities are substantial for adolescents’ development and are influenced by various factors. The present study aimed to investigate the associations between leisure activities and well-being, behavioral difficulties, and parental leisure time engagement.
Methods
A total of 959 adolescents aged 10 to 18 years were included in the present study. We assessed the adolescents’ leisure activities (e.g., family time, meeting friends, different media, organized sports), well-being (Kidscreen-27) and behavioral difficulties (Strengths and Difficulties Questionnaire SDQ) using questionnaires. We applied linear and generalized mixed-effect models to assess associations, adjusting for age group, sex, and SES.
Results
The associations between leisure activities and well-being differed depending on the type of activity. Active leisure (e.g., family time, meeting friends, café visits, visiting a museum/art exhibition/cinema, visiting a concert/opera, voluntary work, physical activity) was associated with better well-being, especially physical well-being, and fewer behavioral difficulties. Passive leisure activities (e.g., screen time, chilling), on the contrary, were associated with lower well-being and more behavioral difficulties. We also observed that adolescents reported greater participation in the described leisure activities if their parents did so. With a few exceptions, leisure behavior did not change during the COVID-19 pandemic.
Conclusion
Our findings underline the importance of leisure activities, their potential impact on adolescents’ well-being and the role parents might play in shaping their children’s leisure time. Therefore, we need to promote the active leisure behavior of young people and their parents.
Methylomic signature of current cannabis use in two first-episode psychosis cohorts
Authors: Dempster Emma , Wong Chloe , Burrage Joe , Hannon Eilis , Quattrone Diego , Giulia Trotta , Rodriguez Victoria , Spinazzola Edoardo , Tripoli Giada , Austin-Zimmerman Isabelle , Li Z , Gayer-Anderson Charlotte , Freeman Tom , Johnson Emma , Jongsma Hannah , Simona Stilo , Cascia Caterina La , Ferraro Laura , Barbera Daniele La , Lasalvia Antonio , Tosato Sarah , Tarricone Ilaria , D’Andrea Giuseppe , Galatolo Michela , Tortelli Andrea , Arango Celso , Jones Peter , Pompili Maurizio , Selten Jean-Paul , de Haan Lieuwe , Menezes Paulo , Del-Ben Cristina Marta , Santos José , Arrojo Manuel , Bobes Julio , Sanjuan Julio , Bernardo Miquel , Breen Gerome , Mondelli Valeria , Dazzan Paola , Iyegbe Conrad , Vassos Evangelos , Morgan Craig , Mukherjee Diptendu , Os Jim van , Rutten Bart , O'Donovan Michael , Sham Pak , Mill Jonathan , Murray Robin , Forti Marta di , Alameda Luis 
Published: September 2023

Abstract

The rising prevalence and legalization of cannabis worldwide have underscored the need for a comprehensive understanding of its biological impact, particularly on mental health. Epigenetic mechanisms, specifically DNA methylation, have gained increasing recognition as vital factors in the interplay between risk factors and mental health. This study aimed to explore the effects of current cannabis use and potency on DNA methylation in two independent cohorts of individuals experiencing first-episode psychosis (FEP) compared to control subjects. The combined sample consisted of 682 participants (cannabis users (n = 188) and never users (n = 494)). DNA methylation profiles were generated on blood-derived DNA samples using the Illumina DNA methylation array platform. Each cohort was analysed individually and then meta-analysed. We identified one CpG site (cg11669285) in the CAVIN1 gene that showed differential methylation with current cannabis use, surpassing the array-wide significance threshold, and independent of the tobacco-related epigenetic signature. Furthermore, a CpG site localized in the MCU gene (cg11669285) achieved array-wide significance in the analysis of high-potency cannabis use. Pathway and regional analyses identified cannabis-related epigenetic deviations in genes linked to immune and mitochondrial function, both of which are known to be influenced by cannabinoids. Notably, the analyses focused on first-onset psychoses identified differential methylation at nominal significance in a CpG site situated in the TRPV2 gene, which is known to be activated by cannabinoids. Overall, these findings contribute to our understanding of the epigenetic consequences of current cannabis use in the general population and in first-episode psychosis and highlight potential molecular pathways affected by cannabis exposure.
Prevalence and residual risk of HIV in volunteer blood donors of Zhejiang Province, China from 2018 to 2022
Authors: Zhu Hong , Ding Wei , Han Wenjuan , Zheng Xiaofan , Hu Yiqing , Dong Jie , Wu Yaling , Wu Danxiao , Liu Jinghui , Zhu Faming 
Published: September 2023

Abstract

Background: Blood safety levels have been significantly improved since nucleic acid amplification technology (NAT) testing for blood donors was carried out, but the residual risk of transfusion transmission infections still exists. Here, the prevalence of HIV and residual risk of the HIV transmission in volunteer blood donors of Zhejiang Province, China for five years after NAT implementation were evaluated.
Materials and methods：All specimens and information were collected from voluntary unpaid donors at all blood services in Zhejiang Province,China from January 2018 to December 2022. HIV antibody/antigen and HIV RNA were detected by enzyme-linked immunosorbent assay and NAT. The residual risk of the HIV transmission was calculated using the incidence/window period model.
Results: A total of 3,375,678 voluntary blood donors were detected, and the HIV prevalence was 9.92/100000. The HIV prevalence of blood donors in twelve blood services in Zhejiang Province were 6.11, 6.98, 7.45, 8.21, 8.36, 8.94, 9.04, 9.66, 9.73, 10.22, 11.80 and 12.47 per 100000 donors, respectively, and the difference of all blood services was not statistically significant (P>0.05).The HIV prevalence of males (15.49/100,000) was significantly higher than that of females (1.95/100,000) (P<0.05). There was no significant difference in HIV prevalence among blood donors of all different age groups( P>0.05), but the HIV prevalence in 26 to 35 age group and 18 to 25 age group were significantly higher than that in 36 to 45 age group( P<0.05).The difference in HIV prevalence between the first-time blood donors (13.65/100,000) and repeat blood donors(6.78/100,000) was statistically significant( P<0.05). From 2018 to 2022, the HIV residual risk in blood transfusion transmission was 0.266/100000.
Conclusion: The prevalence of HIV among blood donors in Zhejiang Province, China is associated with age, gender and times of blood donation. The HIV residual risk in blood transfusion transmission is low in Zhejiang Province and increasing the rate of repeat blood donors is beneficial to improve blood safety.