bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining the benefits and drawbacks of parents using personal connections and social networks for recruitment in research projects: a qualitative study
Authors: Kim Laesa , Costello Carrie , Golding Michael A. , Janse van Rensburg Chloé , Protudjer Jennifer L. P. , Wittmeier Kristy 
Published: July 2023

Abstract
Background
It is becoming more common for parents of children with chronic conditions to join research teams as partners. Parent partnerships can help align research with what is relevant and important to families. It is also common for parent partners to be asked to share information about a study through their personal networks, which supports study recruitment. In this parent-led study, we explored parents' experiences when working together with researchers in patient-oriented research studies, in relation to study recruitment.

Methods
Demographic data were collected through a brief online survey (SurveyMonkey®) and analysed descriptively (n, %, median (interquartile range; IQR)). Qualitative data were collected through focus groups and interviews (July to October 2021), transcribed verbatim, and analysed thematically. Parent co-leads were involved in every stage of the study, including study design, recruitment, data collection, analysis, interpretation, and knowledge mobilization.

Results
Fifteen parents (n = 14 women) who had research partnership experience participated in this study. Most (n = 13) participants self-identified as White or of European descent. The majority (n = 10) had partnered in 1–3 research projects, while five participants had partnered in 4 + projects. Parents had a median of 3 years (IQR: 5) of partnership experience. We identified the following three themes: motivations, authentic partnerships, and learned decision making. Each theme included reflections about recruitment, and about research partnership in general. Motivations included a personal connection to the research topic, a connection to the community impacted by the research topic, and a desire to create change. Authentic partnerships were important for a meaningful experience, and enhanced participant’s willingness and ability to share study materials. Learned decision making reflected parents’ evolving decisions and practices related to sharing study information or personal information to support research. We provide a summary of participants’ recommendations for researchers who work with parent partners, and recommendations for parents as they approach research partnerships.

Conclusions
Experiences shared by parents who have partnered in research provide valuable information to inform recruitment methods and improve team functioning. Parent partners expressed a willingness to support recruitment and valued a strong research team working together for a common outcome. This study yields a set of recommendations guiding future research that engages parents as team members.
Diet, physical activity, and UV protection comprehensively influenced vitamin D status in college students: a cross-section study from China
Authors: Luo Yingyi , Qu Chunbo , Zhang Rui , Zhang Jingyi , Han Dan , Zhang Qingwen , Li Jiaxing , Na Lixin 
Published: July 2023

Abstract
Background
Vitamin D deficiency is one of the most prevalent health problems worldwide in all age groups, whereas vitamin D status of Chinese college students was seldom studied in China. The purpose of this study was to explore the vitamin D status in Chinese college freshmen and its influencing factors, providing evidence for nutrition strategy application.

Methods
Information including demographic status, diet habit, physical activity, and ultraviolet ray (UV) protection was collected by online questionnaire. Serum 25(OH)D3 concentrations were measured using a liquid chromatograph mass spectrometer. Multivariate linear regression analyses were used to explore the comprehensive influence of diet, physical activity and UV protection on serum 25(OH)D3 levels.

Results
Totally 1667 freshmen from 26 provinces, autonomous districts or municipalities, were recruited, with a mean age of 18.6 ± 0.9 years. The mean serum 25(OH)D3 levels were 18.1 ± 6.3 ng/mL and the proportion of vitamin D deficiency and insufficiency was 67.5% and 27.8%, respectively. Multivariate linear regression indicated that higher intake of milk and yogurt, calcium or vitamin D supplementation, and longer time of outdoor activity were positively linked to higher serum 25(OH)D3, while higher intake of candy and higher UV protection index were negatively associated with serum 25(OH)D3, after adjusted for age, gender, region of original residence, latitudes, longitude and BMI.

Conclusions
Vitamin D deficiency is very common in Chinese college students. Milk and yogurt intake and outdoor activity should be encouraged while candy intake should be limited for preventing vitamin D deficiency. Public health policies should focus on these changeable lifestyles and consider well-balanced guidelines on UV protection and vitamin D supplementation.
Neutrophils form extracellular traps in response to Opisthorchis viverrini crude antigens, which are elevated in neutrophils from opisthorchiasis patients with hepatobiliary abnormalities
Authors: Watakulsin Krongkarn , Chuenchom Chalida , Thapphan Chakrit , Thai Tran Duong , Chareonsudjai Sorutsiri , Faksri Kiatichai , Suttiprapa Sutas , Tangkawatana Sirikachorn , Sripa Banchob , Edwards Steven W. , Salao Kanin 
Published: July 2023

ABSTRACT
Opisthorchis viverrini (Ov) infection can cause several disease conditions of the bile duct including hepatobiliary abnormalities (HBAs) and the most severe, cholangiocarcinoma (CCA). Fibrosis occurs when tissues are damaged and normal wound-healing responses are dysregulated. Neutrophils are the first cells to migrate to an infection site to protect the host from intruding extracellular pathogens through a wide range of effector mechanisms such as phagocytosis, production of reactive oxygen species, proteases, or release of neutrophil extracellular traps (NETs). In this work, we used confocal microscopy to assess whether Ov crude antigens can cause release of NETs from neutrophils from Ov-free individuals. We demonstrated for the first time that these antigens could induce release of NETs ex vivo in a dose-dependent manner from neutrophils isolated from Ov-free individuals. Intriguingly, when we measured NETs from neutrophils isolated from Ov-infected patients, we found increased spontaneous production of NETs in patients with HBAs. Interestingly, exposure to Ov crude antigens lowered the level of NETs released by neutrophils from patients with active Ov infection regardless of HBA status. We propose that in the case of acute Ov infection, even when concentration of Ov antigens is relatively low, neutrophils can form NETs. However, when this infection becomes chronic, manifesting as a definite HBA, the levels of NET production are reduced when treated with Ov crude antigens. Excessive production of proinflammatory mediators from these NETs might have effects on the parasites, but may also lead to excessive injury of surrounding tissues resulting in HBAs and may lead eventually to the most severe complications such as CCA.
The factors affecting the survivability of malignant cancer patients with deep vein thrombosis among subjects with gynecologic and non-gynecologic cancer: An ambispective cohort study
Authors: Rachman Andhika , Christine Griskalia , Betsy Rachelle , Juanputra Samuel , Pratiwi Widya 
Published: July 2023

Background: Gynecologic cancer is a significant public health concern worldwide, with three of the top ten most common cancers affecting women. The increasing incidence of deep vein thrombosis (DVT) and the disproportionately poor outcomes in cancer patients necessitates urgent intervention. This study aimed to analyze the factors affecting the survivability of cancer patients with DVT, especially among gynecologic and non-gynecologic cancers. Methods: An ambispective cohort study was conducted among gynecologic and non-gynecologic cancer patients with DVT, from January 2011 until August 2013. Results: Among 223 cancer subjects with DVT, 61.4% of the subjects developed short-term mortality. In the overall group, the survival time was significantly lower in subjects who developed immobilization status (p-value <0.001), advanced cancer stages (p-value <0.045), and infection status (p-value <0.001). In the gynecologic cancer group, the survival time was significantly lower in subjects who developed immobilization (p-value 0.007) and infection status (p-value 0.021). In the non-gynecologic cancer group, the survival time was significantly lower in subjects who developed immobilization (p-value 0.008), infection (p-value 0.002), undergo cancer surgery (p-value 0.024), and received high-risk systemic therapy (p-value 0.048). Additionally, the most common infection was pneumonia (29.6%). Conclusions: Both gynecologic and non-gynecologic cancer patients who experienced DVT developed a high short-term mortality. Our finding of immobility, infection, advanced cancer stages, systemic therapy, and cancer surgery as risk factor that affect the survivability highlights the necessity of administering secondary prophylaxis as a standard procedure in clinical practice.
Europe and Turkey: identities in evolution. An analytical literature review
Authors: Gulmez Seckin Baris , Topal Alp Eren , Rumelili Bahar 
Published: July 2023

This research aims to offer a valid answer to the question of how Turks and Europeans perceived each other in cultural and identity terms throughout history. With this purpose, it makes a thorough analytical review of the extant scholarly literature on identity relations between Turkey and Europe. There is an evident lack of scholarly attention on the evolution of mutual representations comparatively in the long durée. Most scholarly works focus on specific periods of time and investigate either how Turks view Europe or visa-versa. This systematic review provides the basis for an evolutionary analysis of mutual identity representations between Turkey and Europe over more than a two-hundred-year period. The period under focus starts with the French Revolution (1789) triggering intensive identity debates between Ottomans and Europeans and lasts until mid-2010s when bilateral relations between Turkey and the European Union went into disarray. This long period has been divided into four shorter periods each starting and ending with a remarkable event in world politics or bilateral relations. The study examines each period in relation to four focal issues, namely, nationalism, civilization, status in international society, and state-citizen relations generating intensive identity discussions in both Turkey and Europe. The article first presents the key findings of the relevant literature on European representations of Turkey and on Turkish representations of Europe in the four historical periods. Then it scrutinizes the extant literature on each period with respect to the four focal issues. Overall, the study, through a comprehensive literature review, demonstrates the ways in which mutual identity representations in Turkey and Europe have been contested over a two-hundred-year period.
Intergenerational Transmission of Organizational Misconduct: Evidence from the Chicago Police Department
Authors: Frake Justin , Harmon Derek 
Published: July 2023

This paper investigates how organizational misconduct is perpetuated through intergenerational transmission. We theorize that early exposure to a subculture of misconduct imprints newcomers with the belief that misconduct is normal, which is then carried by these individuals into managerial positions and passed down to their subordinates. We test this using longitudinal administrative data from the Chicago Police Department from 1980 to 2017. We exploit a lottery that assigns applicants to training cohorts to demonstrate that officers exposed early on to a subculture of misconduct not only engage in more misconduct over their entire careers, but also increase the misconduct of their subordinates after they become managers. We also find that this intergenerational dynamic is stronger when subordinate officers were exposed to a subculture of misconduct themselves, are earlier in their tenure, and have not yet received their annual review from their manager. Taken together, these findings reveal a bottom-up dynamic whereby beliefs about misconduct are developed in an organization’s lowest ranks, carried by these individuals over time, and passed down to future generations. This study expands our understanding of how organizational misconduct is perpetuated as well as offers important policy implications for addressing the problem of police misconduct. This paper was accepted by Lamar Pierce, organizations. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2022.00580 .
INTELECTUAIS INSURGENTES: NEPS-CEASM, O NÚCLEO DE ESTUDOS E PESQUISA DA FAVELA DA MARÉ
Authors: Manço de Souza Francisco Overlande , Salustriano da Silva Humberto , Paiva da Felicidade Aryanne 
Published: July 2023

Neste artigo, analisamos a perspectiva e produção político-epistemológica do núcleo de pesquisa NEPS-CEASM a partir da atuação de seus pesquisadores no tempoespaço de 2020 a 2023. Os integrantes do referido núcleo de pesquisa são nomeados como intelectuais insurgentes. Neste sentido, realizamos a discussão teórica apontando as características e os pressupostos desta categorização. Nosso objetivo foi descrever a ação-reflexão destes pesquisadores, a relação político-epistemológica através de suas ações e a contextualização dos princípios e valores que caracterizam o intelectual insurgente. A produção do artigo envolveu análise documental das atividades do NEPS-CEASM no recente período de 2020-2023 e bibliográfica. Foi realizada uma breve contextualização histórica da gênese do núcleo de pesquisa que não tem a intenção, neste texto, de aprofundar o período anterior a 2020, mas ressaltar as ações do núcleo com seus atuais participantes. Para tal procedimento de análise utilizamos as atividades presenciais e remotas que o núcleo realizou e a produção acadêmica dos integrantes do núcleo. Destacamos a importância do núcleo como um espaço de fazer científico que utiliza a realidade como ferramenta de análise para pensar a sua produção político-epistemológica.
COMPLEX ANKLE FUSION WITH CIRCULAR FRAMES: FACTORS INFLUENCING OUTCOMES, COMPLICATIONS, AND PATIENT SATISFACTION
Authors: Tay Kae Sian , Langit Mickhael , Muir Ross , Moulder Elizabeth , Sharma Hemant 
Published: July 2023

IntroductionCircular frames for ankle fusion are usually reserved for complex clinical scenarios. Current literature is heterogenous and difficult to interpret. We aimed to study the indications and outcomes of this procedure in detail.Materials & MethodsA retrospective cohort study was performed based on a prospective database of frame surgeries performed in a tertiary institution. Inclusion criteria were patients undergoing complex ankle fusion with circular frames between 2005 and 2020, with a minimum 12-month follow up. Data were collected on patient demographics, surgical indications, comorbidities, surgical procedures, external fixator time (EFT), length of stay (LOS), radiological and clinical outcomes, and adverse events. Factors influencing radiological and clinical outcomes were analysed.Results47 patients were included, with a mean follow-up of three years. The mean age at time of surgery was 63.6 years. Patients had a median of two previous surgeries. The median LOS was 8.5 days, and median EFT was 237 days. Where simultaneous limb lengthening was performed, the average lengthening was 2.9cm, increasing the EFT by an average of 4 months. Primary and final union rates were 91.5% and 95.7% respectively. At last follow-up, ASAMI bone scores were excellent or good in 87.2%. ASAMI functional scores were good in 79.1%. Patient satisfaction was 83.7%. 97.7% of patients experienced adverse events, most commonly pin-site related, with major complications in 30.2% and re-operations in 60.5%. There were 3 amputations. Adverse events were associated with increased age, poor soft tissue condition, severe deformities, subtalar fusions, peripheral neuropathy, peripheral vascular disease, and prolonged EFT.ConclusionsComplex ankle fusion using circular frames can achieve good outcomes in complicated clinical scenarios, however patients can expect a prolonged time in the frame and high rates of adverse events. Multiple risk factors were identified for poorer outcomes, which should be considered in patient counselling and prognostication.
RADIATION DOSE WITH CIRCULAR EXTERNAL FIXATION: DOES THE SURGEON GET A DOUBLE WHAMMY?
Authors: Harris Peter C , Lacey Stephen , Perdomo Amanda , Ramsay Gabby 
Published: July 2023

IntroductionThe vast majority of orthopaedic surgeons use C-arm fluoroscopy in the operating theatre when building a circular external fixator. In the absence of previous research in this area, we hypothesised that the surgeon who builds a circular external fixator is exposed to a greater amount of radiation purely as a result of the presence of the metallic fixator in the x-ray beam. The aim of our study therefore was to investigate how the presence of a circular external fixator affects the radiation dose to the surgeon and the surgical assistant.Materials & MethodsA simulated environment was created using a radiolucent operating table, an acrylic lower limb phantom (below knee segment), various configurations of metalic circular external fixation, and a standard size C-arm image intensifier.The variables investigated were 1. the amount of metal in the beam 2. the orientation of the beam (PA vertical vs lateral) 3. the horizonal distance of the person from the beam (surgeon vs assistant) and 4. the vertical distance of the various body parts from the beam (e.g. thyroid, groin).In terms of radiation dose, we recorded two things : 1. the dose produced by the image intensifier 2. the dose rate at standardised positions in the operating theatre. The latter was done using a solid-state survey sensor. These positions represented both where the surgeon and surgical assistant typically stand plus the heights of their various body regions relative to the operating table..ResultsThe effect of the presence of the circular external fixator : all frame constructs tested resulted in a statistically significant greater radiation dose both produced by the image intensifier and received by the surgical team.The effect of the beam orientation : the PA (vertical) orientation resulted in a statistically significant greater radiation dose for the surgeon than did the lateral orientation, but made no difference for the assistant.The effect of horizontal distance from the beam : unsurprisingly, the surgeon (who was closer to the beam) received a statistically significant greater radiation dose than the assistant. The effect of vertical distance from the beam : for the surgeon, the dose received was highest at the level of the phantom leg / frame, whilst for the assistant there was no statistically significant difference for any level.ConclusionsTo our knowledge, this is the first study investigating the radiation dose rate to the orthopaedic surgeon when building a circular external fixator. We found that the surgeon does indeed receive a ‘double whammy’ because the image intensifier puts out a greater amount of radiation plus the metalic frame scatters more of the x-ray beam. Whilst the amounts are relatively small, we think that it's important to quantify doses that orthopaedic surgeons receive to ensure optimal radiation practices.
PROPHYLACTIC USE OF LOCAL ANTIBIOTICS IN OPEN FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Kapoor Dhruv , Condell Ross , Kennedy Niamh , Bakhshayesh Peyman 
Published: July 2023

IntroductionThe management of open long bone fractures is well described and has been standardised through a number of well-established guidelines. However, there is no consensus regarding the application of local antibiotics into the open fracture site as a means of reducing infection rates.Materials & MethodsA systematic review and meta-analysis were undertaken as per PRISMA guidelines. PROSPERO Registration CRD42022323545. PubMed, EMBASE, Scopus and CENTRAL were the databases assessed. The Newcastle Ottawa Scale and the Rob 2 Tool were used to assess bias. A qualitative synthesis of all included studies and meta-analysis of suitable subgroups was undertaken.ResultsIn total, 12 studies (11 observational, 1 RCT) assessing 2431 open fractures were included for analysis. All compared the addition of a local antibiotic therapy to a standard treatment versus the standard treatment alone. The methods of delivery were vancomycin powder (4 papers), tobramycin polymethylmethacrylate beads (4 papers), gentamicin coated intramedullary (IM) nails (2 papers), gentamicin injections (1 paper) and antibiotic released IM core cement (1 paper). The addition of vancomycin powder did not decrease infection rates in comparison to intravenous antibiotics alone (OR 1.3, 95% CI (0.75 – 2.26)). Antibiotic coated IM Nails appear to have an association with lower infection rates than standard IM Nails. PMMA antibiotics have shown varied results in reducing infection rates depending on the individual studies.ConclusionsThere are numerous methods available to deliver antibiotics locally to an open fracture site. Further high-quality research is required to provide a definitive conclusion on their efficacy irrespective of delivery method.
INTERNATIONAL FIELD TEST OF LIMB-Q KIDS: AN INTERNATIONALLY APPLICABLE PATIENT-REPORTED OUTCOME MEASURE FOR LOWER LIMB DIFFERENCES
Authors: Wright Jonathan , Messner Juergen , McMahon Sarah , Johnson Louise , Foster Patrick , Fernandes James , Chhina Harpreet , Klassen Anne , Cooper Anthony 
Published: July 2023

IntroductionLIMB-Q Kids is a new patient-reported outcome measure (PROM) for children with Lower limb differences (LLDs). The objective is to conduct an international field test study.Materials & MethodsA mixed method multiphase approach was used to develop LIMB-Q Kids. In phase one, a systematic review was conducted to identify concepts from existing PROMs used in research with children with LLDs. A preliminary conceptual framework derived from the systematic review informed an international qualitative study. The data from qualitative interviews were used to form the LIMB-Q Kids, which was further refined through multiple rounds of cognitive debriefing interviews with children. Input was obtained from parents and healthcare professionals from Australia, Canada, Ethiopia, India, UK, and the USA. LIMB-Q Kids was translated and culturally adapted into multiple languages.ResultsThe final field-test version consists of 11 scales (159 items) that measure appearance, physical function, symptoms (hip, knee, ankle, foot, and leg), leg-related distress, and school, social and psychological function. This version was rigorously translated into Danish and German. Translations that are in progress include Arabic, Finnish, Hindi, Swahili, Portuguese, Spanish, and Luganda. An international field-test study is underway in nine countries (15 sites with a target recruitment of 150 participants per country). At the time of abstract submission, 190 patients from seven sites have completed LIMB-Q Kids. The UK collaborative has worked on language adaption for the UK and is currently validating the score across five paediatric limb reconstruction units.ConclusionsNo internationally applicable PROM exists for children with LLDs. We present the current progress in developing and validating such a score. Data from the international field-test study will be used to reduce items and perform psychometric testing of LIMB-Q Kids. The rigorous translation and cultural adaption process will provide versions of LIMB-Q Kids in different languages. Once completed, the LIMB-Q Kids will provide a common metric for outcome assessment for children with lower limb differences internationally.