bluuebunny/crossref_metadata_2025_split huggingface dataset:
AKAP12 inhibits the proliferation of ovarian cancer by activating the Hippo pathway
Authors: Liu Xiao , Chen Xiaoming , Liu Lei , Xia Jun , Zhang Hong 
Published: September 2023

Abstract

Background
Ovarian cancer is a prominent cause of mortality among women worldwide. A kinase anchor protein 12 (AKAP12) has been investigated, but its contribution to ovarian cancer is unclear.

Objectives
This study comprehensively investigates the role of AKAP12 in ovarian cancer proliferation by elucidating its underlying mechanisms and functions.

Methods
We compared the expression levels of AKAP12 in ovarian cancer and adjacent tissues. We subsequently established A2780 and HO8910 cell lines that have undergone AKAP12 overexpression or knockdown to verify the function of AKAP12 in ovarian cancer. To determine the effect of AKAP12 on tumorigenicity, migration, and invasion, we performed CCK-8, colony-formation, xenograft models, transwell, and wound healing assays. Furthermore, we used pathway enrichment analysis to identify Hippo signaling related to AKAP12 overexpression. Then we characterized the relevance of Hippo signaling in AKAP12-regulated tumor suppressive effects in ovarian cancer through western blot.

Results
Our study revealed a significant decrease in AKAP12 expression in ovarian cancer samples. Moreover, functional assays demonstrated the tumor suppressive effects of AKAP12 overexpression, inhibiting cancer cell proliferation, migration, and invasion. Consistent with these findings, mice inoculated with AKAP12-overexpressing cells exhibited slower tumor growth in our mouse xenograft model. We also observed a positive relationship between AKAP12 overexpression and Hippo pathway-related proteins.

Conclusions
AKAP12 plays a crucial role in the suppression of ovarian cancer through activation of the Hippo signaling pathway. Furthermore, it could be a potential target for developing new therapeutic strategies for ovarian cancer treatment.
The Good Morning—Exercise Technique and Exercise Selection Principles
Authors: Ross Steven , Comfort Paul , McMahon John 
Published: September 2023

ABSTRACT
The good morning is a barbell exercise that can be used to develop muscular strength and hypertrophy in the posterior chain (i.e., hamstring muscles, gluteal muscles, spinal erectors, calf complex). The exercise uses a hip hinge motion with the barbell positioned across the upper trapezius, offering lifters an alternative to more common posterior chain exercises, such as the Romanian deadlift. The good morning may be particularly beneficial for lifters with lower levels of grip strength or upper-limb injury, which may prevent using a clean or opposing grip. This review describes exercise techniques and discusses some of the underpinning principles of the exercise and potential applications in training.Video Abstract—http://links.lww.com/SCJ/A393.
EFECTO DE LAS VARIABLES FISICOQUÍMICAS EN LA COMUNIDAD DE COLEÓPTEROS ACUÁTICOS EN UN HUMEDAL COSTERO, LIMA, PERÚ
Authors: Córdova-Tello Carolina Aymeé , Huamantinco-Araujo Ana Asuncion 
Published: September 2023

El Refugio de Vida Silvestre Los Pantanos de Villa (RVSLPV) es el único humedal costero ubicado dentro del área urbana de Lima que es reconocido como sitio Ramsar. Poco se conoce sobre la diversidad de macroinvertebrados que habitan la zona y qué factores ambientales tienen influencia sobre estos organismos. El objetivo de este estudio fue determinar la composición de la comunidad de coleópteros acuáticos y evaluar sus relaciones con las variables fisicoquímicas del agua. Para ello se establecieron 12 estaciones de muestreo en seis lagunas del RVSLPV y se evaluaron in situ los parámetros: oxígeno disuelto (OD), conductividad eléctrica (CE), temperatura del agua (T), potencial de hidrógeno (pH) y turbidez (Turb). Se identificaron 1475 coleópteros acuáticos agrupados en tres familias y 13 especies, reportando dos nuevos registros para el Perú: Desmopachria challeti K. B. Miller (Dytiscidae) e Hydraena quechua Perkins (Hydraenidae). Los Análisis de Componentes Principales (ACP) y de Correspondencia Canónica (ACC) mostraron que las variables fisicoquímicas e mayor influencia fueron CE, pH y turbidez; además, encontramos que las especies de Hydrophilidae se asocian a una alta tolerancia a la CE. Por el contrario, relacionados con valores menores al promedio de T, CE, Turb, OD y una alcalinidad ligeramente alta, ocurren las especies de Dytiscidae e Hydraenidae (excepto G. peruvianus); estas requerirían de otras condiciones probablemente relacionadas al tamaño y profundidad de las lagunas, así como con la diversidad florística.
Caracterización fisicoquímica y propiedades morfológicas de quitina y quitosano de Bombyx mori L. Híbrido Pílamo 1
Authors: Guerreo Álvarez Gloria Edith , Baena Luz Marina 
Published: September 2023

El uso de biomateriales como la quitina y el quitosano ha venido aumentando en los últimos años y con esto sus aplicaciones biotecnológicas. Una fuente alternativa de obtención de estos son los insectos, entre los que se incluye el Bombyx mori L. (gusano de seda). En esta investigación se obtuvieron y caracterizaron quitina y quitosano a partir del Bombyx mori L Hibrido Pilamo 1 que se produce en el departamento de Risaralda, Colombia. Los biomateriales se extrajeron con NaOH al 10 % y HCl 1N y se caracterizaron por infrarrojo (IR-TF), microscopia electrónica de barrido (SEM), espectroscopía de rayos x de energía dispersa (EDS), análisis termogravimétrico (TGA) y calorimetría diferencial de barrido (DSC). El contenido de quitina en las crisálidas fue del 2.1 % en base seca. En el espectro IR de la quitina se encontraron las señales características a 1618 cm−1 y 1655 cm−1 correspondientes al estiramiento de C-N, vibración C=O de la amida I, a 1545 cm-1 del estiramiento de N-H de la amina II y a 3256 cm-1 de los grupos NH2 y OH. El espectro IR del quitosano evidenció la desacetilación por la señal a 1590 cm-1 y la señal a 1654 cm-1, presentando una mayor intensidad que la quitina debido al aumento de grupos NH2. La acetilación para la quitina fue del 61.83 % y para quitosano del 12.37 %; este resultado es de gran importancia considerando su relación con la solubilidad. Las microscopias mostraron diferentes morfologías superficiales que pueden deberse a la fuente de obtención, el método de extracción o grado de desacetilación. Las principales características de la quitina y quitosano obtenidos coinciden con estudios previos reportados para otras razas de gusano de seda, sin embargo, es necesario continuar la investigación, para establecer si es posible emplear al Bombyx mori L. Híbrido Pílamo 1 como una fuente promisoria de estos biomateriales disponible en la región.
Influencia del abono verde en los atributos físicos de un Latosol Amarillo distrófico
Authors: Martins Costa Romário , Parra-Serrano Luisa Julieth , Silva Torquato Lohana , Cunha de Meneses Kamila , Furtado de Farias Maryzelia 
Published: September 2023

El objetivo de este estudio fue evaluar el desempeño de leguminosas/gramíneas en rotación, utilizadas como abonos verdes, en un Latosol Amarillo distrófico en el bioma de Cerrado en Maranhão, Brasil. Se utilizó un diseño de bloques al azar en parcelas subdivididas, con parcelas compuestas por las especies Cajanus cajan, Canavalia ensiformis y Mucuna aterrima el primer año; Pennisetum americanum, Sorghum bicolor y Sorghum sudanense el segundo año, además del testigo (vegetación espontánea). Las subparcelas estuvieron constituidas por dos temporadas de evaluación: temporada 1 (antes de la siembra) y temporada 2 (después del cultivo de las plantas cobertura). Se evaluó la productividad de fitomasa verde y seca; la densidad y la resistencia a la penetración del suelo en profundidades de 0-10, 10-20, 20-30 y 30-40 cm. Las especies C. ensiformis y S. bicolor presentan la mayor productividad de fitomasa, lo que demuestra una mejor adaptación de esas especies a las condiciones edafoclimáticas de la región. Las especies leguminosas del primer año no proporcionaron mejorías a las características físicas del suelo. Mientras que las especies gramíneas del segundo año, cultivadas en rotación con las leguminosas, contribuyeron a la reducción de la densidad y de la resistencia del suelo a la penetración.
El concepto de etnia en un país pluriétnico y multicultural: una representación desde un grupo de estudiantes de odontología
Authors: Ruiz–Gómez Adiela , González–Bernal María Alejandra , Delgado–García José Martín 
Published: September 2023

Objetivo: explorar el concepto de <<etnias>>, en un grupo de estudiantes de Odontología de una universidad privada. Métodos: Se realizó un estudio cualitativo con 11 estudiantes entre 18 y 21 años en una Facultad de Odontología de una Universidad de Bogotá, en el curso de Socio Humanística I. Se efectuó una entrevista semiestructurada a cada estudiante; se obtuvo el consentimiento informado, el estudio fue clasificado como sin riesgo. Se aplicó en una sesión una entrevista semiestructurada, organizada en forma de historia donde el estudiante se involucra al leer el relato y contestar los interrogantes a medida que transcurría la lectura, lo que sirvió como base para el análisis de contenido. Resultados: Se determinaron tres categorías a saber: concepto de etnia, grupos étnicos en Colombia y enfoque diferencial étnico en salud, encontrándose que la etnia para los estudiantes es el reconocimiento de multietnicidad y pluriculturalidad del país, acompañado de diversidad. Conclusión: Con relación al concepto de etnia, se resalta que para algunos de los encuestados hay una confusión con representar los grupos étnicos como: madres cabeza de hogar, desplazados y población LGBTI. Los estudiantes respondieron “Raizales, negritudes, indígenas, Rom, desplazados, adultez, vejez, niñez, LGTBI.” Que, aunque tienen relación con el enfoque diferencial, no corresponden al interrogante planteado en la historia.
Detección y barreras de medición de delirium en Unidad de cuidado intensivo: Una revisión de alcance
Authors: León López Kevin David , HENAO CASTAÑO ANGELA MARIA , Alves de Araujo Püschel Vilanice 
Published: September 2023

Objetivo: identificar las estrategias de enfermería para la detección de delirium y las barreras para su medición en la unidad de cuidado intensivo (UCI).
Materiales y método: revisión de alcance a partir de la metodología del Instituto Joanna Briggs y el protocolo PRISMA-ScR, mediante una búsqueda en seis bases de datos con los términos “delirium”, “diagnosis”, “nursing”, “critical care” y “critical care nursing” y la extracción del software SUMARI.
Resultados: se seleccionaron 43 estudios para análisis y categorización en dos temáticas emergentes: “Herramientas de uso frecuente para la detección del delirium” y “Barreras reportadas por el personal de enfermería para la evaluación del delirium”.
Conclusiones: existe una gran variedad de herramientas validadas y estandarizadas para la detección del delirium en cuidado intensivo. No obstante, su uso es limitado en muchas ocasiones debido a las distintas barreras del paciente, el personal evaluador y el equipo multidisciplinar. Por ello, resulta importante entrenar al personal de salud para que esté familiarizado con el delirium, su detección y el uso de los múltiples instrumentos disponibles.
Inflation measurement in times of large consumption shifts – Evidence of the CPI bias from Poland
Authors: Hałka Aleksandra , Leszczyńska-Paczesna Agnieszka 
Published: September 2023

AbstractThe paper addresses the problem of inflation measurement and the way it is affected by the choice of CPI weights. We focus on the bias resulting from using weights reflecting the past structure of consumption and the choice of the plutocratic index. The study is based on a comparison of the official consumer price index in Poland with superlative indices. Contrary to most literature, our findings indicate an understatement of the CPI. Additionally, in 2020 due to large changes in the pattern of household consumption, the underestimation increased. This results from the increase in the expenditure on the relatively more expensive goods which could not be accounted for in real time. In general, the lack of overstatement in the Polish CPI may result from frequent adjustments in the weights used for the calculation of CPI and a faster-than-CPI rise in the prices of those goods and services for which demand is relatively inelastic. Additionally, we deliver the estimates of the plutocratic gap, which indicates that the use of the plutocratic weights in the calculation of CPI leads to a lower price index than its democratic equivalent.
Falsificationist Treatment of Auxiliary Hypotheses in Social and Behavioral Sciences
Authors: Uygun Tunç Duygu , Tunç Mehmet Necip 
Published: September 2023

Auxiliary hypotheses AHs are indispensable in hypothesis-testing, because without them specification of testable predictions and consequently falsification is impossible. However, as AHs enter the test along with the main hypothesis, non-corroborative findings are ambiguous. Due to this ambiguity, AHs may also be employed to deflect falsification by providing “alternative explanations” of findings. This is not fatal to the extent that AHs are independently validated and safely relegated to background knowledge. But this is not always possible, especially in the so-called “softer” sciences where often theories are loosely organized, measurements are noisy, and constructs are vague. The Systematic Replications Framework (SRF) provides a methodological solution by disentangling the implications of the findings for the main hypothesis and the AHs through pre-planned series of systematically interlinked close and conceptual replications. SRF facilitates testing alternative explanations associated with different AHs and thereby increases test severity across a battery of tests. In this way, SRF assesses whether the corroboration of a hypothesis is conditional on particular AHs, and thus allows for a more objective evaluation of its empirical support and whether post hoc modifications to the theory are progressive or degenerative in the Lakatosian sense. Finally, SRF has several advantages over randomization-based systematic replication proposals, which generally assume a problematic neo-operationalist approach that prescribes exploration-oriented strategies in confirmatory contexts.
Studi Keberagamaan dari Masa ke Masa
Authors: Suhartini Rr 
Published: September 2023

Keberagamaan masyarakat merupakan realitas yang tak terbantahkan keberadaannya sepanjang sejarah hidup manusia, baik yang terlaporkan dalam sebuah penelitian ilmiah maupun tidak ilmiah atau hanya sebagai sebuah legenda. Hasil penelitian yang berserakan itu sangat menarik untuk dipanggil kembali dan dipetakan, sehingga dapat ditemukan pola gerak perkembangan keberagamaan masyarakat. Untuk dapat memperoleh hasil pemetaan yang representatif, peneliti mencari jurnal-jurnal dan buku-buku hasil penelitian maupun hasil pemikiran terkait dengan keberagamaan masyarakat (Muslim maupun Non-Muslim), diterbitkan sejak tahun 1912-2008 berasal dari dalam negeri maupun luar negeri.
Hasil penelusuran menunjukkan adanya kecenderungan pergeseran fokus kajian tentang keagamaan adalah dari hal-hal yang dogmatic ke arah lebih empiric berorientasi pada worldviews. Kekuatan dan kemampuan religius berorientasi worldviews bergerak ke arah multikultural religius melalui penerimaan kenyataan plural. Penerimaan kenyataan plural ini ternyata bukan sesuatu yang mudah diterima begitu saja, karena membutuh penguatan atau pengalaman tertentu sehingga mampu melakukan dekonstruksi religius. Masing-masing berusaha memperbaiki atau melengkapi kapasitas religiusitas mereka untuk mencapai suatu tingkat spiritualitas tertentu dalam realitas obyektif yang bersifat plural.
Assessing durability properties of ultra-high performance concrete-class materials
Authors: Saladi Naveen , Montanari Luca , De la Varga Igor , Spragg Robert , Graybeal Benjamin 
Published: September 2023

AbstractUltra-high performance concrete (UHPC) is a class of concrete materials that has received significant attention from the infrastructure community due to its favorable mechanical and durability performance. As the use of UHPC in infrastructure projects is becoming more common, there is an increasing interest in identifying appropriate testing techniques to assess the durability properties of UHPC-class materials. The dense microstructure of UHPC-class materials and the presence of a high concentration of fiber reinforcement have made it difficult to rely on existing standard testing approaches for concrete durability assessment. This study explores the application of various conventional-concrete durability test methods to UHPC, including electrical resistivity (American Association of State Highway and Transportation Officials (AASHTO) TP 119-22), freeze–thaw (ASTM C666), water absorption (ASTM C1585), and rapid chloride migration test (NT BUILD 492). The selected tests are meant to qualify and quantify the microstructural penetrability of UHPC to ions and fluids, a surrogate property commonly used as an indicator of durability. The findings from this study indicate that electrical resistivity can be used as a durability indicator for UHPC-class materials. Moreover, strong correlation between electrical resistivity and the chloride migration coefficient is identified, a potential benefit given that chloride migration can be used to estimate service lives of UHPC-class materials. Other tests, including freeze–thaw and water absorption, although identifying the favorable performance of UHPC relative to conventional concrete, were unable to provide insightful information through which the performance of individual UHPCs could be differentiated.
Effects of postoperative lateral positioning on outcomes of patients with subarachnoid hemorrhage
Authors: KİŞİAL Ceylan , ERDEN Sevilay 
Published: September 2023

Purpose: This study was conducted to investigate the effects of postoperative lateral positioning on the patients’ outcomes with subarachnoid hemorrhage.
Materials and Methods: This study, which is a randomized controlled intervention study, was conducted with 42 (experimental group: 21, control group: 21) patients who underwent subarachnoid hemorrhage surgery in the neurosurgery intensive care unit of a university hospital and met the sampling criteria. In the study, "Patient Descriptive Information Form" and "Patient Results Form" were used as data collection tools. A total of 42 patients operated on for subarachnoid hemorrhage were included in the study. While the patients in the intervention group were placed in the left lateral, right lateral, and semi-fowler position (30 degrees) every 2 to 4 hours for the first 72 hours, those in the control group were routinely placed in the semi-fowler position (20 to 45 degrees).
Results: The power of hydrogen value and partial oxygen pressure and arterial oxygen saturation at the 48th hour in the intervention group were statistically significantly higher than the control group at the 72nd hour. In the intervention group, a slight decrease was observed only in the heart rate at 72 hours, which was near normal.
Conclusion: Lateral and semi-fowler positions with a 2 to 4 hour interval contributed to improved oxygenation and prevented secondary complications of subarachnoid hemorrhage.
Reclassification of clinical exome data leads to significant clinical assessment changes in almost half of the patients
Authors: BAYRAKTAR Umut Arda , ŞAHİN Feride İffet , POLAT Mert , TERZİ Yunus Kasım 
Published: September 2023

Purpose: With the global accumulation of genetic/clinical data, we are understanding the clinical significance of the reclassification of pathogenicity for gene variants. We hypothesized that this evolution in classification(s) may cause clinically-relevant discrepancies in the genetic risk assessment of subjects. In this study, we sought to reclassify the clinical exome sequence (CES) data of our patients to assess whether these changes would have clinical significance.
Materials and Methods: The study included CES data of 23 cases diagnosed with cancer or familial cancer predisposition. The variants were first classified in 2020 and then reclassified a year after based on the ACMG database. Chart reviews were performed to record clinical history and interventions.
Results: In the first classification of CES data, a total of 80 variants were identified as being not benign (26 likely pathogenic/pathogenic and 54 variants of undetermined significance (VUS)). The clinical significance of fifteen variants (19%) changed after reclassification in 10 patients (43%). The only upgraded variant was the c.9097 dup in exon 23 of BRCA2 gene (likely pathogenic to pathogenic). Fourteen variants were downgraded at reanalysis in 9 patients: from pathogenic to likely pathogenic (2 variants), pathogenic to VUS (2), likely pathogenic to VUS (4), and VUS to benign (6).
Conclusion: Considering that the clinical significance of CES data changed due to reclassification in almost half of the studied patients, we believe genetic variant-related data should be assessed at regular intervals, regardless of follow-up status in the clinic.
Is there any correlation between integrated pulmonary index and thoracic surgery patients’ follow-up data? a prospective, observational study
Authors: ABDULKAREM Zaid , TÜRKTAN Mediha , GÜLEÇ Ersel , HATİPOĞLU Zehra , BİNOKAY Hulya , ÖZCENGİZ Dilek 
Published: September 2023

Purpose: In this study, we investigated the relationship between integrated pulmonary index and patients’ demographic data, surgical characteristics, postoperative complications, blood gas analysis, and hemodynamic values after thoracic surgery.
Materials and Methods: A total of 97 patients scheduled for elective thoracic surgery were included in this study. After surgery, integrated pulmonary index monitoring was performed for all patients in the post-anesthetic care unit. Patients’ characteristics, postoperative hemodynamic values, arterial blood gas analysis, length of hospital stay, postoperative complications, duration of anesthesia, and duration of surgery were recorded. Their correlations with postoperative integrated pulmonary index scores at 30 minutes, 1 hour, and 2 hours were investigated.
Results: Patients’ demographic data and surgical characteristics did not affect integrated pulmonary index scores. No significant correlation was found between integrated pulmonary index scores and duration of anesthesia, duration of surgery, postoperative complications, or length of hospital stay. However, there was a correlation between postoperative hemodynamic values, arterial blood gas analysis and integrated pulmonary index score.
Conclusion: Integrated pulmonary index monitoring is a bedside and non-invasive method that displays multiple parameters on a single screen, corraletes with arterial blood gas analysis and hemodynamic values. Therefore, it may provide advantages in early follow-up of thoracic surgery patients. However, multicenter, randomized controlled studies with a larger number of patients are needed to investigate the efficacy of integrated pulmonary index in patients undergoing thoracic surgery.