bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double Auction based Incentive Mechanism for Participatory Sensing Systems
Authors: Middya Asif Iqbal , Roy Sarbani 
Published: July 2023

Abstract
The sensors that are available in smartphones are useful to explore a diverse range of city dynamics (e.g. noise pollution, road condition, traffic condition, etc.). The potential of the smartphone sensors coupled with their widespread availability help to emerge a new paradigm of sensing known as participatory sensing. It uses the power of smartphone equipped sensors to collect, store, and analyze data with high spatiotemporal granularity. In a participatory sensing based system, a task provider (also known as a crowdsourcer) may have a set of sensing tasks regarding different dynamics of a city. Here, adequate users’ participation is necessary to acquire a sufficient amount of data which is a key factor for the participatory sensing based systems to provide good service quality. The task providers appoint a set of task executors (smartphone users i.e. participants of crowdsensing tasks) to execute those sensing tasks. But, existing works on sensing task allocation suffer from lack of good incentive mechanisms that are attractive for the task executors. In order to address this issue, in this paper, a double auction based incentive mechanism called TATA (Truthful Double Auction for Task Allocation) is proposed for participatory sensing. TATA performs fair allocation of tasks which is leading to efficient incentive mechanism. In the case of TATA, the fair allocation of sensing tasks of the task providers to the task executers indicates that the proposed double auction mechanism is able to satisfy the truthfulness property in order to resist market manipulation (i.e., untruthful bidding and asking). Specifically, TATA achieves all the desirable properties like individual rationality, truthfulness (i.e. incentive compatibility), budget balance, etc. TATA is also computationally efficient and yields high system efficiency. Additionally, the performance of the proposed incentive mechanism is evaluated and compared with the existing mechanisms through extensive simulations based on the real-world data from Amazon Mechanical Turk. TATA yields high utility and satisfaction for the task providers and executors as compared to the existing mechanisms.
Development and validation of a nomogram to estimate future risk of metabolic syndrome in middle-aged and elderly people
Authors: 谢 思思 , Liu Huangyao , Liu Yanhong , Xu Cong , Zhang Ting , Wang Qi , Li Jian , Huang Zhengchun , Li Sisi , Hao Ming , Dong Minghua , Luo Xiaoting , Wu Qingfeng 
Published: July 2023

Abstract
Aims
This study aimed to investigate the prevalence of Metabolic syndrome (MetS) and its influencing factors among middle-aged and elderly Chinese, and to develop a nomogram for predicting MetS.
Methods
This cross-sectional study were the follow-up visits of the Gannan Medical University cohort study. The participants were permanent residents aged 35 years and above living in Ganzhou, Jiangxi, China. MetS was defined according to the Chinese Diabetes Society (CDS) criteria. Participants’ demographics, history of illness, blood biochemistry data, and anthropometric variables were enrolled into screen significant variables for prediction model of MetS, Subsequently, the data was divided into a training set and a validation set, and nomogram were performed to develop the predictive model of MetS. The training set was used for nomogram model construction and internal verification, and the validation set was used for external verification. Nomogram performance was assessed based on receiver operating characteristic curve (ROC) analysis, calibration curves, and decision curve analysis (DCA).
Results
A total of 1581 participants were enrolled in the study, and the prevalence of MetS was 27.39% (95%CI:25.19%-29.59%). The age-standardized prevalence was 12.51%. Nine variables (age, residence, occupation, hyperlipidemia, hyperuricemia, family history of hypertension, hip circumference, glycated hemoglobinA1c (HbA1c), BMI, resting heart rate (RHR)) were identified as influencing factors of MetS. The participants were randomly divided into a development cohort (n = 1107,70%) and a validation cohort (n = 474, 30%). The nomogram was verified by internal validation (Area Under Curve (AUC): 0.844) and external validation (AUC: 0.825). The calibration plots showed good agreement in the training sets.
Conclusion
The prevalence rate of MetS is high in Ganzhou, Jiangxi, China. The nomogram based on nine variables has a good predictive efficacy and can be used to predict the risk of MetS in middle-aged and elderly people.
Pathways of effects of adverse childhood experiences on infectious diseases among border drug-use adults: A Structural Equation Modeling
Authors: Zhang Mingmei , He Jianhui , Lu Tian , Luo Ou , You Jing , Li Jing 
Published: July 2023

Abstract
Background
Injection of drug abuse could result in infectious disease, and adverse childhood experiences (ACEs) possibly are associated with infectious disease. However, there is a paucity of literature on a direct or indirect relationship between ACEs, injection of drug use and infectious disease. We thus identified the pathway of influence of ACEs in adulthoods and injection of drug use on infectious disease by structural equation models (SEM).
Methods
A cross-sectional study was conducted by respondent driving sampling and consecutive sampling among adult drug users in southwest of China in 2021. R software 4.2.1 was used to conduct descriptive, univariate, and SEM analysis.
Results
There were 404 participants in total, with an average age of 34 and most males (98.3%) and minorities (79.6%). 95.5% of respondents experienced ACEs with 46.6% of reporting 4 or more ACEs. Correlations in SEM showed that infectious disease was directly positively affected by injection of drug use (β = 0.184), and directly negatively affected by ACEs (β=-0.188). Age(β = 0.029), Ethnic(β=-0.021), Education(β = 0.019), Gender(β = 0.022), Sex partners (β=-0.017), and ACEs (β=-0.029) had indirect effects on infectious disease.
Conclusions
ACEs could be a direct or indirect predictor for infectious disease in adulthood, injection of drug use could be a risk factor and moderate other factors of infection of infectious disease. Strategies for creating a positive home environment, minimizing traumatic or stressful childhood experiences, and increasing awareness of the risks associated with drug injection use are all ways to lower the chance of contracting infectious diseases.
The economic and technical feasibility analysis for solar power plant
Authors: Sandilya Rajeev Ranjan 
Published: July 2023

Abstract
The solar power plants connected to the grid has emerged as reliable green energy to supplement conventional energy fossil fuel power plants connected to the grid. The efforts of Indian government agencies and private business entities to achieve a greater share in the green energy market segment have led to a substantial increase in installation of solar power projects in India. The generation of power from conventional energy fossil fuel power plants are the sources of greenhouse gases emission, which contribute to global warming. India has the potential to generate green energy through solar power plants connected to the grid. Solar power projects are built up through government entities, private enterprises, and public-private partnerships (PPP) enterprises. The provision of tie-ups with local business enterprises as joint ventures or special purpose vehicles (SPV) for capital investment provides a boost for solar power projects in India. The solar power projects are completed for commercial operations in a much shorter timeframe in comparison to conventional energy fossil fuel power projects. The capital investment for solar power projects has become economical in the present time due to the development of Photovoltaic module technology. The economies of scale associated with an increase in production, lower the cost of Photovoltaic (PV) modules. The decrease in capital cost and decrease in operating cost associated with the increase in efficiency of solar power plants and the financial incentive scheme introduced by the government of India provide attractive business opportunities for the green energy value chain in India. The economic and technical assessment for the solar power projects connected to grid provides guidance for the project development of upcoming grid connected solar power projects in the future foreseen period.
Incidence and Impact of Concomitant Vascular Injury on Biliary Enteric Repair in Post-Cholecystectomy Bile Duct Injury Patients
Authors: Singla Saurabh , Singh Rakesh , Kumar Saket , kumar Sanjay , Mandal Manish , Raj Amarjit 
Published: July 2023

Abstract
Background: Concomitant vascular injury occurs in significant proportion of patients with post cholecystectomy biliary injury. Such vascular injury mostly remains asymptomatic but may manifest with liver abscess, lobar ischemia or anastomotic strictures in long term. Our aim is to determine incidence of associated vascular injury in such patients and its impact on early complications rates and outcomes following biliary repair.
Methods: This prospective study was done between November 2019 and December 2021. All patients with post cholecystectomy bile duct injury were investigated for vascular injury by contrast enhanced computed tomography. The presentation and outcomes of biliary repair were studied in patients with and without associated vascular injury.The outcomes were graded according to Mcdonald classification scheme.
Results: Concomitant vascular injury incidence was 39% (n=19) in total of 48 patients studied. Incidence of vascular injury was proportional to the grade of biliary injury. In Strasberg type 4 injury, 87% had vascular injury while in type 3, 42% had vascular injury, and in type 2, 27% patients had vascular injury. Liver abscess was significantly higher in patients with concomitant vascular injury. Mean duration of hospital stay was 6.6± 3.9 days. After 1 year of biliary repair, irrespective of vascular repair, 60% patients had Mcdonald Grade A outcome.
Conclusion: 39%patients with biliary injury have concomitant vascular injury. Higher grade of biliary injury is associated with vascular injury. Vascular injury is not associated with increased morbidity, length of hospital stay or inferior medium term repair complications if delayed repair is done.
Multi-scale and multi-modal imaging study of mantle xenoliths and petrological implications
Authors: Venier Marco , Ziberna Luca , Mancini Lucia , Kao Alexander P. , Bernardini Federico , Roncoroni Giacomo , Milani Sula , Youbi Nasrrddine , Majigsuren Yondon , De Min Angelo , Lenaz Davide 
Published: July 2023

Abstract
The accurate textural characterization of mantle xenoliths is one of the fundamental steps to understanding the main processes occurring in the upper mantle, such as sub-solidus recrystallization, magmatic crystallization, and metasomatism. Texture, composition, and mineralogy reflect the temperature, pressure, stress conditions, melting, and/or contamination events undergone before and during the entrapment in the host magma. For these reasons, characterizing the three-dimensional (3D) texture of silicate, oxide, sulfide, and glass phases has great importance in the study of mantle xenoliths. We performed a multi-scale and multi-modal 3D textural analysis based on X-ray computed microtomography (µ-CT) data of three mantle xenoliths from different geodynamic settings (i.e., mobile belt zone, pericraton, oceanic hotspot). The samples were selected to represent different, variably complex internal structures composed of grains of different phases, fractures, voids, and fluid inclusions of different sizes. We used an approach structured in increasing steps of spatial and contrast resolution, starting with in-house X-ray µ-CT imaging (spatial resolution from 30 µm down to 6.25 µm) and moving to high-resolution synchrotron X-ray µ-CT at the micrometer scale.
We performed a 3D characterization of mantle xenoliths, comparing the results with the analysis of conventional 2D images (thin sections) obtained by optical microscopy and simulating the random sectioning of several thin sections to estimate the probability of correct modal classification. The 3D models allow the extraction of textural information that cannot be quantified solely from thin sections: spinel layering, distribution of silicic glass, and related vesicles. Moreover, high-density volumes identified as sulfides were detected in two xenoliths, showing no relation with the spinel layering in one case and a preferential concentration along fractures in the other. Given the variety of textures and mineral assemblages of mantle xenoliths worldwide, the results are used to suggest experimental and analytical protocols for the characterization of these materials.
Efficient removal of perfluorinated compounds with the polyamide nanofiltration membrane and membrane fouling resistance analysis
Authors: Wu Yuyang 
Published: July 2023

Abstract

Perfluorinated compounds (PFCs) are significant pollutants known for their high toxicity and resistance to natural degradation, posing a severe threat to both the global environment and human health. In this study, a polyamide (PA) membrane with an intermediate layer structure of MXene-TiO2 (referred to as MXT-NFM) was utilized for the removal of PFCs. Experimental results confirm that MXT-NFM exhibited remarkable capacity in intercepting PFCs, accompanied by the high water flux. To gain insights into the mechanisms governing membrane fouling induced by PFCs, inorganic ions, and organics, a series of fouling tests were conducted using MXT-NFM under diverse conditions. Additionally, the XDLVO theory was employed to provide a theoretical perspective on the interactions occurring during the fouling process. The findings suggest that the MXene-TiO2 intermediate layer contributed to the exceptional hydrophilicity and rough surface properties, enabling multiple functionalities. These include alleviating membrane pore plugging, improving the physical configuration of the PA layer, and effectively mitigating fouling phenomena in coexisting systems during practical applications. Moreover, the particle size of pollutant colloids and the acid–base interaction were identified as decisive factors influencing the development of membrane fouling.
Molecular Mechanisms and Therapeutic Potential of Resolvins in
Cancer - Current Status and Perspectives
Authors: Tajbakhsh Amir , Yousefi Fatemeh , Farahani Najmeh , Savardashtaki Amir , Reiner Željko , Jamialahmadi Tannaz , Sahebkar Amirhossein 
Published: July 2023

:
Resolvins are specialized pro-resolving mediators derived from omega-3 fatty
acids that can suppress several cancer-related molecular pathways, including important
activation of transcription parameters in the tumor cells and their microenvironment, inflammatory
cell infiltration, cytokines as well as chemokines. Recently, an association between
resolvins and an important anti-inflammatory process in apoptotic tumor cell clearance
(efferocytosis) was shown. The inflammation status or the oncogene activation increases
the risk of cancer development via triggering the transcriptional agents, including
nuclear factor kappa-light-chain-enhancer of activated B cells by generating the pro-inflammatory
lipid molecules and infiltrating the tumor cells along with the high level of
pro-inflammatory signaling. These events can cause an inflammatory microenvironment.
Resolvins might decrease the leukocyte influx into the inflamed tissues. It is widely accepted
that resolvins prohibit the development of debris-triggered cancer via increasing
the clearance of debris, especially by macrophage phagocytosis in tumors without any
side effects. Resolvins D2, D1, and E1 might suppress tumor-growing inflammation by
activation of macrophages clearance of cell debris in the tumor. Resolvin D5 can assist
patients with pain during treatment. However, the effects of resolvins as anti-inflammatory
mediators in cancers are not completely explained. Thus, based on the most recent
studies, we tried to summarize the most recent knowledge on resolvins in cancers.
An Insight on Skin Cancer About Different Targets With Update on
Clinical Trials and Investigational Drugs
Authors: Vishwas Suraj , Das Paul Swarnali , Singh Deepika 
Published: July 2023

Abstract:
Cancer is a diverse disease caused by transcriptional changes involving genetic and epigenetic
features that influence a huge variety of genes and proteins. Skin cancer is a potentially fatal disease
that affects equally men and women globally and is characterized by many molecular changes. Despite
the availability of various improved approaches for detecting and treating skin cancer, it continues to be
the leading cause of death throughout society. This review highlights a general overview of skin cancer,
with an emphasis on epidemiology, types, risk factors, pathological and targeted facets, biomarkers and
molecular markers, immunotherapy, and clinical updates of investigational drugs associated with skin
cancer.

:
The skin cancer challenges are acknowledged throughout this study, and the potential application of
novel biomarkers of skin cancer formation, progression, metastasis, and prognosis is explored. Although
the mechanism of skin carcinogenesis is currently poorly understood, multiple articles have
shown that genetic and molecular changes are involved. Furthermore, several skin cancer risk factors
are now recognized, allowing for efficient skin cancer prevention. There have been considerable improvements
in the field of targeted treatment, and future research into additional targets will expand
patients’ therapeutic choices. In comparison to earlier articles on the same issue, this review focused on
molecular and genetic factors and examined various skin cancer-related factors in depth.
Self-assembling Peptides (SAPs) as Powerful Tools for the Preparation of Antimicrobial and Wound-Healing Nanostructures
Authors: Dimmito Marilisa Pia , Marinelli Lisa , Cacciatore Ivana , Valeri Anna Lucia , Rapino Alessandra , Di Stefano Antonio 
Published: July 2023

:
Supramolecular self-assembly (SA) is a naturally occurring and free energy-driven process of molecules to produce nanostructured systems depending on the assembling environment. SA molecules have captivated the research attention since they possess singular physicochemical properties that are potentially useful to make the nanostructures quite suitable for biomedical applications, such as diagnostics, drug delivery, tissue engineering, and regenerative medicine. Due to their high biological activity and low toxicity, the self-assembly properties of peptides bid certain advantages as drugs and drug delivery platforms. Among the discovered self-assembling bioactive peptides (SAPs), antimicrobial peptides (AMPs) are widely distributed through plant and animal kingdoms and play a key role as an alternative strategy to fight infections bypassing conventional antimicrobial drugs, susceptible to antimicrobial resistance. Based on this evidence, in this review, we summarized the mechanism of the self-assembling of peptides, the main forces responsible for the SAPs formation, and the studies regarding their possible implication in infectious diseases as well as wound dressing materials.
1,3,4-Oxadiazoles as Anticancer Agents: A Review
Authors: Kumar Greesh , Kumar Rajnish , Mazumder Avijit , Salahuddin  , Kumar Upendra 
Published: July 2023

Abstract:
Among the deadliest diseases, cancer is characterized by tumors or an increased number
of a specific type of cell because of uncontrolled divisions during mitosis. Researchers in the
current era concentrated on the development of highly selective anticancer medications due to the
substantial toxicities of conventional cytotoxic drugs. Several marketed drug molecules have provided
resistance against cancer through interaction with certain targets/growth factors/enzymes,
such as Telomerase, Histone Deacetylase (HDAC), Methionine Aminopeptidase (MetAP II),
Thymidylate Synthase (TS), Glycogen Synthase Kinase-3 (GSK), Epidermal Growth Factor
(EGF), Vascular Endothelial Growth Factor (VEGF), Focal Adhesion Kinase (FAK), STAT3,
Thymidine phosphorylase, and Alkaline phosphatase. The molecular structure of these drug molecules
contains various heterocyclic moieties that act as pharmacophores. Recently, 1,3,4-
oxadiazole (five-membered heterocyclic moiety) and its derivatives attracted researchers as these
have been reported with a wide range of pharmacological activities, including anti-cancer. 1,3,4-
oxadiazoles have exhibited anti-cancer potential via acting on any of the above targets. The presented
study highlights the synthesis of anti-cancer 1,3,4-oxadiazoles, their mechanism of interactions
with targets, along with structure-activity relationship concerning anti-cancer potential.
Pulsatilla saponin A Inhibits Proliferation and Induces Apoptosis in Diffuse Large Bcell
Lymphoma Cells through the JAK2/STAT3 Signaling Pathway
Authors: Liu Ning , Zhan Xinzhuo , Bai Jie , Yu Hui , Chen Xiaoli , Kong Xiangtu , Ni Haiwen 
Published: July 2023

Objective:
This study aimed to investigate the performance of Pulsatilla saponin A (PsA) in diffuse large
B-cell lymphoma (DLBCL) cells.

Methods:
Proliferation, ELISA, apoptosis, cell cycle analysis, and assays were carried out to detect the growth and
apoptosis in DLBCL cells. Western blotting was used to identify the change in the protein.

Results:
In cell assays, PsA significantly inhibited the growth and apoptosis in DLBCL cells. The IL-10 and TNF-α of
OCI-LY10 and U2932 cells were reduced after 24 h PsA treatment. Bax, cleaved PARP, and cleaved Caspase-3 were
increased, while Bcl-2 and C-Myc decreased after PsA treatment. IL-10 may regulate the expression of C-Myc protein
in cells by activating the JAK2/STAT3 signaling pathway. PsA can inhibit the overexpression of p-JAK2 and p-
STAT3 signaling pathways induced by IL-10 stimulants. The proliferation and apoptosis induced by PsA were confirmed
in DLBCL cells.

Conclusion:
Our findings revealed that PsA may exert its antitumor effect by causing G1 arrest and apoptosis in
DLBCL cells. The mechanism of PsA regulating apoptosis in DLBCL cells is probably through the JAK2/STAT3
signaling pathway in vitro.
Analysis of MMSE Multiuser Detector in a Low-density Parity Check
Coded Large Scale MIMO OFDM
Authors: Shoukath Shefin , Haris P. Abdul 
Published: July 2023

Background:
Large-scale MIMO OFDM technique satisfies the demands on performance
and the service quality preferred in wireless communication systems. Since numerous antenna terminals
have been incorporated in the base station, multiuser detection is crucial for retrieving the data
appropriately. Thus, the complexities of the detectors increase rapidly in large-scale MIMO OFDM
schemes.

Objective:
This work is a solution to achieve an extensively high rate of data transmission, which will
help improve the capacity of the LS MIMO OFDM system.

Methods:
A unique detection approach of multiuser detection in LS MIMO OFDM model with channel
coding, like Low Density Parity Check Codes (LDPC), is suggested in this paper. The LDPCcoded
large-scale MIMO OFDM system has also been analysed in the study with users of around ten
at the transmitter and several antennas in the base station.

Results:
BER of the LDPC-coded LS MIMO OFDM exhibited a waterfall region for SNR greater
than 6dB as the study has been done with different decoding iterations. The BER performance
worsened with the increase in modulation symbols. The study has shown how the BER performance
has improved with respect to the increasing fading channels and subcarriers.

Conclusion:
The proposed system exhibited performance closer to the MIMO capacity with low
complexity MMSE detection. The multiuser detector of LDPC-coded LS MIMO OFDM has been
analysed by error rate in received bits (BER) with respect to different parameters, such as modulation
orders, iteration values, receiving antennas, and OFDM subcarriers.