bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Anti-Corrosion Efficiency and Antimicrobial Properties of Green Synthesised Nickel Oxide (NiO) Nanoparticles
Authors: Sheit H. Mohamed Kasim , Mubarak M. Seeni , Mohamed M. Varusai , Jayaprasadh M. , Mohan K.S. , Gunavathy K.V. 
Published: March 2023

Abstract
The numerous treatments for nano particles in the interdisciplinary field of biomedical self-discipline cannot be counted. Many researchers in biomedicine are intrigued by metallic-based nano particles. Several methods for synthesizing metal nano particles are under investigation, and green synthesis is considered a presumed choice due to its environmentally benign nature, safety from harmful chemicals, and economically favorable for synthesis. The target of the current research include the synthesis of nickel oxide nano particles (NiO NPs) through green route by using the extract prepared from the bark of Acacia Nilotica, and the analysis of its characteristics using XRD, SEM, EDAX, IR, UV-VIS, Photo luminescence spectra, microbial activity, mass loss scheme and electrochemical techniques. The diffraction analysis using X-ray (XRD) indicates the presence of NiO2 compound in the prepared nano particles. The Fourier transform Infrared spectroscopy (FTIR) confirmed the association of peaks with the C-H and Ni-O bonds present. The micro images from Scanning Electron Microscope (SEM) exhibited cubic cluster morphology on its surface. The UV Vis spectra showed a maximum absorption at 264 nm. The Photoluminescence spectrum demonstrated that the green synthesized NPs of NiO has a modified emission band due to the presence of oxygen deficiencies and induced surface imperfections. A study on its microbial application confirms that the prepared NiO NPs have a great potential for inhibition against bacteria such as S. aureus and E. coli and also instrumental against microorganic fungi, Candida albicans and A. niger. The mass loss system shows a restraint effectiveness of 93.68 percent in carbon steel and the electrochemical study supports the formation of a defensive protective layer on the cathodic locales of the carbon steel surface.
Evolutionary Game Analysis of UGC Copyright Infringement Governance
Authors: Yang Sen 
Published: March 2023

Abstract
Based on the assumption of bounded rationality, this paper constructs an evolutionary game model of "government-platform-platform user," discusses the strategic interaction between different subjects and the influence effect of various factors, and explores the copyright governance mechanism of UGC in China. It is found that: The UGC copyright governance mechanism is a mechanism for the collaborative participation of multiple subjects at different levels, in which government departments are in a leading position in the construction of the mechanism, and platform participation in governance can significantly improve regulatory efficiency. Increasing the severity of government penalties, reducing the excess revenue of passive filtering of platforms, and the extra payment of users' infringing use can accelerate the realization of evolutionary stability strategies. There is a practical threshold for government incentives for platforms.
A simple fully conformal solution of Einstein's gravitational equations and the agreement of its implications with astrophysical data
Authors: Dvorsky Richard 
Published: March 2023

Abstract
Another cosmological redshift mechanism could exist in general relativity, as is differences in the global metric field gμν between the radiation source in the past, and the observer in the present, known as gravitational redshift in massive stars. In this paper, we present a fully conformal global metric model with time scaling that would lead to the above alternative interpretation of the cosmological redshift. It is based on a relatively simple global solution of Einstein's gravitational equations without the cosmological term, and the analysis also shows other interesting astrophysical implications. The model naturally solves the problem of critical density and spatial flatness, as well as the problem of cosmological redshift in the spectra of distant astrophysical sources, and the problem of Olbers' and Seeliger's paradox. At the same time, it replaces the strict causal horizon principle with a much softer formulation-the region of the practically observable universe. Confrontation with astrophysical data provides interesting agreement with the spatial distribution of astrophysical radiation sources such as γ-ray bursts and quasars. However, probably the most important consequence is the new, generalized formulation of Hubble's law z(r) = (exp(Hr/c)-1), which shows good agreement R 2 ≈ 0.9824 with experimental data even for very distant sources. The paper also physically justifies in principle the modification of Newton's law of gravity for infinite space proposed by Seeliger. The modifying exponential term exp(-Hr/c) is uniquely quantified by the Hubble parameter and the speed of light.
Unexpected functional and structural diversity in deubiquitinases of the Chlamydia-like bacterium Simkania negevensis
Authors: Boll Vanessa , Hermanns Thomas , Uthoff Matthias , Erven Ilka , Hörner Eva-Maria , Kozjak-Pavlovic Vera , Baumann Ulrich , Hofmann Kay 
Published: March 2023

Abstract
Besides the regulation of many cellular pathways, ubiquitination is important for the defence against invading pathogens. Some intracellular bacteria have evolved deubiquitinase (DUB) effector proteins, which interfere with the host ubiquitin system and help the pathogen to evade xenophagy and lysosomal degradation. Most intracellular bacteria encode one or two DUBs, which are often linkage-promiscuous or preferentially cleave K63-linked chains attached to bacteria or bacteria-containing vacuoles. By contrast, the respiratory pathogen Legionella pneumophila possesses a much larger number of DUB effectors, among them a K6-specific enzyme belonging to the OTU family and a M1-specific DUB uniquely found in this bacterium. Here, we report that the opportunistic pathogen Simkania negevensis, which is unrelated to Legionellabut has a similar lifestyle, encodes a similarly high number of DUBs, including M1- and K6-specific enzymes. The SimkaniaDUBs are highly diverse and include DUB classes never before seen in bacteria. Interestingly, the M1- and K6-specific DUBs of Legionella and Simkaniaare unrelated, suggesting that their acquisition happened independently. We have characterized the DUB activity of eight Simkania-encoded enzymes belonging to five different DUB classes. We also provide a structural basis for the M1-specificity of a Simkania DUB, which most likely evolved from a eukaryotic otubain-like precursor.
Validation of Local Thermal Equilibrium (LTE) in Porous Media for Variation in Flow rate and Permeability: Transient Analysis
Authors: Rudresh Gudekota , Rathore Surendra Singh , Mehta Balkrishna 
Published: March 2023

Abstract
The usage of porous media is one of the effective ways to augment the heat transfer in micro-to-mini scale channels due to its enormously high surface area, enhanced thermophysical properties, and dispersion effect to transfer the thermal energy between the heated channel wall and fluid at a faster rate. However, there is ambiguity associated with the extent of thermal equilibrium between the solid and fluid phases, and therefore, also in the selection of suitable heat transfer model. In the current study, the numerical analysis of thermo-hydrodynamics for the porous media filled in the channel for incompressible laminar forced convective flow with varying Reynolds number and Darcy number is delt. The validity of the local thermal equilibrium (LTE) condition is performed for transient case to study the effects of the parameters that governs the flow and thermal effects, i.e., Reynolds number (Re) in the range of 10 < Re < 1000 and Darcy number (Da) in the range of 10^-6 < Da < 10^0 . The results of the present study show that for higher range of flow rate (Re > 100), the LTE assumption is valid for all ranges of Da, however, for the lower range of flow rate (Re < 100), the LTE assumption deviates for higher Da
RORB, an Alzheimer’s disease susceptibility gene, is associated with viral encephalitis, an Alzheimer’s disease risk factor
Authors: Lehrer Steven , Rheinstein Peter 
Published: March 2023

Abstract
Background: Viral encephalitis increases later-life risk of Alzheimer’s disease (AD) by a factor of 31.
Methods: To further evaluate this finding, we examined the relationship of West Nile virus (WNV) to Alzheimer’s disease in 50 US states. In addition, we performed a genome wide association study (GWAS) of viral encephalitis cases in UK Biobank (UKBB) to see if any encephalitis genes might be related to AD.
Results: WNV was significantly associated with deaths from Alzheimer’s disease in 50 US states (r = 0.806, p < 0.001). One gene, RORB-AS1, was most significantly related on GWAS to viral encephalitis. RORB-AS1 (RORB Antisense RNA 1) is an RNA gene. Diseases associated with RORB-AS1 include childhood epilepsy and idiopathic generalized epilepsy. The closely related RORB (Related Orphan Receptor B) is a marker of selectively AD vulnerable excitatory neurons in the entorhinal cortex; these neurons are depleted and susceptible to neurofibrillary inclusions during AD progression.
Conclusion: data presented here confirm the association of viral encephalitis with AD and suggest that WNV infection is a significant AD risk factor. A human WNV vaccine could reduce Alzheimer’s disease morbidity and mortality. In addition, GWAS suggests that the gene RORB, an important AD vulnerability factor, is significantly related to viral encephalitis.
Non-hermiticity in spintronics: oscillation death in coupled spintronic nano-oscillators through emerging exceptional points
Authors: Wittrock Steffen , Perna Salvatore , Lebrun Romain , Ho Katia , Dutra Roberta , Ferreira Ricardo , Bortolotti Paolo , Serpico Claudio , Cros Vincent 
Published: March 2023

Abstract
The emergence of exceptional points (EPs) in the parameter space of a non-hermitian (2D) eigenvalue problem is studied in a general sense in mathematical physics, and has in the last decade successively reached the scope of experiments. In coupled systems, it gives rise to unique physical phenomena, which enable novel approaches for the development of seminal types of highly sensitive sensors. Here, we demonstrate at room temperature the emergence of EPs in coupled spintronic nanoscale oscillators and hence exploit the system’s non-hermiticity. We describe the observation of amplitude death of self-oscillations and other complex dynamics, and develop a linearized non-hermitian model of the coupled spintronic system, which properly describes the main experimental features. Interestingly, these spintronic nanoscale oscillators are deployment-ready in different applicational technologies, such as field, current or rotation sensors, radiofrequeny and wireless devices and, more recently, novel neuromorphic hardware solutions. Their unique and versatile properties, notably their large nonlinear behavior, open up unprecedented perspectives in experiments as well as in theory on the physics of exceptional points. Furthermore, the exploitation of EPs in spintronics devises a new paradigm for ultrasensitive nanoscale sensors and the implementation of complex dynamics in the framework of non-conventional computing.
A review on the use and applications of Volatile Fatty Acids on fecal sludge sanitization
Authors: Zewde Abraham Amenay , Li Zifu , Zhou Xiaoqin 
Published: March 2023

Abstract
Basic sanitation is still lacking in many developing countries, resulting in significant environmental health risks. The efficient disposal of food waste with potential resource recovery has recently gained much attention. Food waste is considered to be a favourable substrate for the anaerobic digestion (AD) because it has easy biodegradability, rich nutrient availability, and high water content. Waste disposal as well as energy recovery can be achieved through AD of food waste. Volatile fatty acids (VFAs) are among the essential intermediates produced when organic waste is treated in the AD process. They are produced during the acidogenesis and acetogenesis stages of AD. VFA is an important substrate for the microorganisms that are involved in the production of biodegradable plastics, bioenergy, nutrient removal processes, and the inactivation of pathogens. Since the degree of acidification and the key metabolic pathways during fermentation are influenced by the characteristics of the substrate, the amount and composition of VFAs obtained during the AD process may vary depending on the substrate used. This article reviews the achievements and applications of VFAs to inactivate pathogens.
Time-restricted Feeding Changes as Inspiration for Drug Design
Authors: He Zhangyuting , Yang Huayu , Mao Yilei 
Published: March 2023

:
Time-restricted feeding (TRF) is a special lifestyle intervention that improves glucose metabolism,
regulates lipid metabolism, increases gut micro richness, and strengthens circadian rhythm. Diabetes is a
remarkable component of metabolic syndrome, and individuals with diabetes can benefit from TRF. Melatonin
and agomelatine can strengthen circadian rhythm, which is a crucial mechanism of TRF. New drug designs can
be inspired by the related mechanisms and influences of TRF on glucose metabolism, and more researches are
needed to clarify the specific diet-related mechanisms and apply this knowledge to further drug design.
Wstępne studium budowy głębokowodnego portu morskiego „Władysławowo”
Authors: Wójcicki Tadeusz 
Published: March 2023

W Polsce prawdziwe nabrzeża głębokowodne znajdują się jedynie w porcie morskim w Gdańsku. Niewątpliwie tak korzystne warunki hydrotechniczne sprawiły, że port w Gdańsku jest największy. Pociąga to za sobą również skutki niekorzystne, spowodowane nadmiernym skupieniem przeładunków na niewielkiej przestrzeni oraz stanowi zagrożenie niezawodności dostaw morskich do portów. Warto zatem rozważyć zasadność i możliwość budowy dodatkowego portu głębokowodnego, położonego w obrębie aglomeracji gdańskiej, ale na jej północno-zachodnim krańcu, czyli na odcinku wybrzeża między Karwią a Władysławowem. Tę ogólną lokalizację od nazwy największego miasta w rejonie nazwano „Władysławowo”. W niniejszym artykule dokonano analizy planistycznych, urbanistycznych, komunikacyjnych, hydrologicznych i ekologicznych warunków budowy portu „Władysławowo”. Na tej podstawie wykonano analizę celowości inwestycji, która doprowadziła do wniosku o zasadności realizacji inwestycji, wobec czego zaproponowano 5 wariantów lokalizacji, a następnie przeprowadzono dla nich analizę wielokryterialną i określono wariant optymalny. Celowość inwestycji wykazano poprzez jej porównanie z konkurencyjnymi, opracowanymi już planami rozbudowy istniejących portów w Gdańsku i Gdyni przez ich uzupełnienie o nowe części głębokowodne, zwane odpowiednio Portem Centralnym i Portem Zewnętrznym. Opracowany ogólny program inwestycji przewiduje powstanie w ramach portu dużej bazy kontenerowej, terminali gazowego (LNG) i naftowego, bazy promowej, nabrzeży dla statków pasażerskich, a ponadto części wojennej. Przyjęto lokalizację portu na otwartym morzu na sztucznej wyspie albo półwyspie, odrzucając jednocześnie możliwość lokalizacji portu w głębi lądu. Określono wstępnie następujące warianty lokalizacji dla projektowanego portu: „Karwia”, „Ostrowo”, „Chłapowo”, „Cetniewo” i „Władysławowo Centrum”, a następnie dla każdego wariantu określono ogólne uwarunkowania lokalne. Na tej podstawie wykonano analizę wielokryterialną wariantów, w wyniku której okazało się, że optymalną lokalizacją inwestycji jest wariant 2 „Ostrowo”, ale można również brać pod uwagę niewiele gorszą, drugą w kolejności lokalizację, tj. wariant 5 „Władysławowo Centrum”. Oba te warianty są najmniej uciążliwe dla środowiska, charakteryzują się małą długością toru wodnego do portu i stosunkowo niskim poziomem konfliktowości społecznej. Słowa kluczowe: transport wodny, budowa portów morskich, optymalizacja lokalizacji inwestycji transportowych, studia wykonalności, hydrologia, ochrona środowiska
Development of a Secondary Prevention Smartphone App for Students With Unhealthy Alcohol Use: Results From a Qualitative Assessment
Authors: Bertholet Nicolas , Schmutz Elodie , Cunningham John A , McNeely Jennifer , Gmel Gerhard , Daeppen Jean-Bernard , Grazioli Véronique S 
Published: March 2023

Background
Despite considerable efforts devoted to the development of prevention interventions aiming at reducing unhealthy alcohol use in tertiary students, their delivery remains often challenging. Interventions including information technology are promising given their potential to reach large parts of the population.

Objective
This study aims to develop a secondary prevention smartphone app with an iterative qualitative design involving the target population.

Methods
The app development process included testing a first prototype and a second prototype, developed based on the results of 2 consecutive qualitative assessments. Participants (aged ≥18 years, screened positive for unhealthy alcohol use) were students from 4 tertiary education institutions in the French-speaking part of Switzerland. Participants tested prototype 1 or prototype 2 or both and provided feedback in 1-to-1 semistructured interviews after 2-3 weeks of testing.

Results
The mean age of the participants was 23.3 years. A total of 9 students (4/9 female) tested prototype 1 and participated in qualitative interviews. A total of 11 students (6/11 female) tested prototype 2 (6 who tested prototype 1 and 5 new) and participated in semistructured interviews. Content analysis identified 6 main themes: “General Acceptance of the App,” “Importance of the Targeted and Relevant App Content,” “Importance of Credibility,” “Importance of the App Usability,” “Importance of a Simple and Attractive Design,” “Importance of Notifications to Ensure App Use over Time.” Besides a general acceptance of the app, these themes reflected participants’ recommendations toward increased usability; to improve the design; to include useful and rewarding contents; to make the app look serious and credible; and to add notifications to ensure its use over time. A total of 11 students tested prototype 2 (6 who tested prototype 1 and 5 new) and participated in semistructured interviews. The 6 same themes emerged from the analysis. Participants from phase 1 generally found the design and content of the app improved.

Conclusions
Students recommend prevention smartphone apps to be easy to use, useful, rewarding, serious, and credible. These findings may be important to consider when developing prevention smartphone apps to increase the likelihood of app use over time.

Trial Registration
ISRCTN registry 10007691; https://www.isrctn.com/ISRCTN10007691

International Registered Report Identifier (IRRID)
RR2-10.1186/s13063-020-4145-2
An Online Acceptance and Mindfulness Intervention for Chronic Pain in Veterans: Development and Protocol for a Pilot Feasibility Randomized Controlled Trial
Authors: Reilly Erin D , Kathawalla Ummul-Kiram , Robins Hannah E , Heapy Alicia A , Hogan Timothy P , Waring Molly E , Quigley Karen S , Drebing Charles E , Bickmore Timothy , Volonte Matias , Kelly Megan M 
Published: March 2023

Background
In the veteran community, chronic pain is particularly prevalent and often debilitating. Until recently, veterans with chronic pain were offered primarily pharmacological intervention options, which rarely suffice and can also have negative health consequences. To better address chronic pain in veterans, the Veterans Health Administration has invested in novel, nonpharmacological behavior interventions that target both pain management and chronic pain–related functional issues. One approach, acceptance and commitment therapy (ACT) for chronic pain, is supported by decades of efficacy evidence for improving pain outcomes; however, ACT can be difficult to obtain owing to issues such as a lack of trained therapists or veterans having difficulty committing to the time and resources needed for the full clinician-led ACT protocol. Given the strong ACT evidence base combined with access limitations, we set out to develop and evaluate Veteran ACT for Chronic Pain (VACT-CP), an online program guided by an embodied conversational agent to improve pain management and functioning.

Objective
The aims of this study are to develop, iteratively refine, and then conduct a pilot feasibility randomized controlled trial (RCT) of a VACT-CP group (n=20) versus a waitlist and treatment-as-usual control group (n=20).

Methods
This research project includes 3 phases. In phase 1, our research team consulted with pain and virtual care experts, developed the preliminary VACT-CP online program, and conducted interviews with providers to obtain their feedback on the intervention. In phase 2, we incorporated feedback from phase 1 into the VACT-CP program and completed initial usability testing with veterans with chronic pain. In phase 3, we are conducting a small pilot feasibility RCT, with the primary outcome being assessment of usability of the VACT-CP system.

Results
This study is currently in phase 3; recruitment for the RCT began in April 2022 and is expected to continue through April 2023. Data collection is expected to be completed by October 2023, with full data analysis completed by late 2023.

Conclusions
The findings from this research project will provide information on the usability of the VACT-CP intervention, as well as secondary outcomes related to treatment satisfaction, pain outcomes (pain-related daily functioning and pain severity), ACT processes (pain acceptance, behavioral avoidance, and valued living), and mental and physical functioning.

Trial Registration
ClinicalTrials.gov NCT03655132; https://clinicaltrials.gov/ct2/show/NCT03655132

International Registered Report Identifier (IRRID)
DERR1-10.2196/45887
Omissões ortográficas na escrita infantil: relação entre posição silábica e escolaridade (Orthographic omissions in children’s writing: relationship between syllabic position and schooling )
Authors: Chacon Lourenço , Silva Marciel Antonio Alves da 
Published: March 2023

A investigação teve como objetivos verificar em que medida omissões ortográficas dependeriam (1) das diferentes posições que os grafemas ocupam na estrutura da sílaba; e (2) da relação entre essas posições e a seriação escolar. Os dados foram extraídos de 190 produções escritas de crianças do Ciclo I do Ensino Fundamental de uma escola pública do estado de São Paulo. Foram quantificadas todas as omissões ortográficas nas posições silábicas investigadas (ataque, núcleo e coda) e, depois, comparadas em função dos três anos de que se compõe esse Ciclo. Os resultados mostraram: quanto ao primeiro objetivo, predomínio das omissões em coda silábica; quanto ao segundo objetivo, variação da distribuição das omissões nas diferentes posições da sílaba em função do ano escolar. Características fonético-fonológicas da sílaba, combinadas com práticas pedagógicas que enfatizam o trabalho com a estrutura silábica consoante-vogal, permitiram explicar as tendências apontadas pelos resultados.
Path Diagram of entrepreneurship in the COVID-19 era
Authors: García Lirios Cruz 
Published: March 2023

- The process that goes from prospective decisions (oriented to risks of maximum profits with respect to minimum insurance benefits) to deliberate actions (oriented by avoidance of failures, based on the systematization of errors and successes) is addressed in the present work, aiming to specify a model for the study of Internet entrepreneurship. A non-experimental study was carried out with a non-probabilistic selection of 100 entrepreneurs. From a structural model, the reflective factor of the construct was found to be deliberate actions, but such findings are only applicable to the sample since the type of study, sampling, and statistical analysis suggest the contrast of the model in other scenarios would increase the percentage of the explained variance of its factors, that added to 57% in this case.