bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping of Electric Utilities in Roadways using GIS in Erode City
Authors: Kumaar K.Santhosh , Suchithra S. , Ambika D. , Rajkumar R. 
Published: January 2023

Abstract
Urbanization has become a major phenomenon in India were lakhs are migrating every year increasing the traffic congestions. In many places over population has affected the local authorities even to provide basic transport services. Traffic problems in India are already an extensive task and will become much difficult due to urbanization and changing lifestyle of people. This analysis introduces a solution to the problem in transportation in erode city. In this project the electrical obstructions for transportation movement been identified and mapped by which they can be removed or altered in their routes. An integrated approach to electric utility mapping is more than the sum of its parts. Location and mapping teams need to participate in a multi-phased process that includes lobbying and action on their part. They must be involved from start to finish. This project aims at mapping the electric utilities such as electric poles and transformers in major roadways of Erode City [Corporation limits] using GIS. These utilities have been mapped and differentiated based on their impact to the traffic flow operations in the roads. Initially, locating the utilities has been done through GPS (Global Positioning Systems) which will be very useful for finding the accurate latitude and longitude values. And then, mapping of utilities is carried out through GIS (Geographic Information Systems) which give better results in mapping. The software used for mapping is QGIS. The electric utilities which are obstructions to traffic movement are all to be identified and mapped which will be later altered in their alignment or removed.
Optical Features of PVC Polymer Thin Films Doped by Compound Organosilane to Raise the Absorbance of Samples Driven to the Light
Authors: Al-Mashhadani Mohammed H. , Abed Rasheed N. , Yousif Emad , Hashim Hassan , Jawad Ali H. , Bufaroosha Muna 
Published: January 2023

Abstract
The novel work for this study is to make new films for the pure and doped PVC with organosilane thus it was used organosilane moieties (25 mg) were mixed with poly(vinyl chloride) (5 g). Thus drop-casting procedure was utilized to make these thin films. The pure PVC and PVC-Organosilane optical properties were studied under the wavelength range from (250–1300 nm) using diffusive reflectance equipment. The optical properties like absorption increased up to (87–95%), while reflectance and transmittance decreases when added organosilane molecules. Furthermore, the dielectric constant (real and imaginary) and optical conductivity enhanced, respectively. On the other hand, Urbach energy increases when adding organosilane to PVC structure, furthermore, skin depth, refractive index, and optical density were figured. The energy gap is reduced from 4 eV to 2.3 eV for the direct transition and from 3.9 eV to 1.6 eV for the indirect transition. SEM analysis was implemented over thin films of pure PVC and PVC-Organosilane to see the morphology of these surfaces. The AFM analysis was utilized to exhibit the topography of the surfaces. Thereby, finding the surface roughness and the root means square of the surface for these thin films. The improvement for these thin films is used in many applications such as photostability and absorption the light when used in radars applications.
Reaction route, mechanism, and procedure of the photoredox of U(Ⅵ) and Sb(Ⅲ) using a Fe 3 O 4 /TiO 2 /g-C 3 N 4 heterojunction nano- photocatalyst under visible sunlight
Authors: Wang Chun , Jiao Han , Yang Yinbo , Wei Lihong , Na Ping 
Published: January 2023

Abstract
Magnetic Fe3O4/TiO2/g-C3N4, as a stable and recyclable ternary two-layer heterojunction nano-photocatalyst, has been synthesized to integrate the merits of each which can remove U(Ⅵ) and Sb(Ⅲ) through responding to almost full-wave band of visible of sunlight. Meanwhile through the combination of actual tests (free radical trapping tests), characterization (XRD, FT-IR, Raman, XPS, EXAFS and EPR) and theoretical calculations structure optimization, band structures, TDOS, electrostatic potential, charge density difference and Bader charge analysis) revealed reaction route, catalytic mechanism and reaction procedure of this photocatalytic reaction. It was found that the adsorption process took place between TiO2/ g-C3N4 heterostructure in the form of (C3)–N–U(Ⅵ)–O2c–Ti and N…Sb(Ⅲ)–O2c–Ti where N(g-C3N4) and O(TiO 2) played decisive roles. The built-in electric field and electronic structure motivated TiO2 and g-C3N4 to accumulate a large amount of e- to reduce U(Ⅵ) and h+ to oxidize Sb(Ⅲ) respectively, and completed the light-induced redox reaction by making full use of the e-, •OH and O2• ⁻ produced by photoexcited carriers which were difficult to recombine, finally, heterojunction complexes of (C3)–N–U(Ⅳ)–O2c–Ti, C=N–U(Ⅳ)–O2c–Ti and N…Sb(Ⅴ)–O2c–Ti were formed. Moreover, the two-way effect of O2• ⁻ proved that the redox of U(Ⅵ) and Sb(Ⅲ) had a coupling relationship. In addition, Fe3O4/TiO2/g-C3N4 prevented the damage of Fe3O4's photodissolution to its structure while Fe3O4 provided a new and interrelated path for the redox of U(Ⅵ) and Sb(Ⅲ).
Temporal trends in inequalities of the burden of HIV/AIDS across 186 countries
Authors: Deng Penghong , Chen Mingsheng , Si Lei 
Published: January 2023

Abstract
Background: The Global Burden of Disease, Injuries, and Risk Factors Study (GBD) has reported that HIV/AIDS continues to take a disproportionate toll on global health. However, the trends in global inequality of HIV/AIDS burden have remained ambiguous over the past two decades. The objectives of our study were to assess the socioeconomic inequalities, and temporal trends of HIV/AIDS across 186 countries and territories from 2000 to 2019.
Methods: We extracted data from the GBD 2019, and conducted a cross-national time-series analysis. Age-standardized disability-adjusted life-year (DALY) rates were used to measure the global burden of HIV/AIDS. Gross national income (GNI) per capita was used to approximate the national socioeconomic status. Linear regression analysis was conducted to investigate the relationship between age-standardized DALY rates due to HIV/AIDS and GNI per capita. The concentration curve and concentration index (CI) were generated to evaluate the cross-national socioeconomic inequality of HIV/AIDS burden. A joinpoint regression analysis was used to quantify the changes in trends in socioeconomic inequality of HIV/AIDS burden from 2000 to 2019.
Results: A decrease in age-standardized DALY rates for HIV/AIDS occurred in 132 (71%) of 186 countries/territories from 2000 to 2019, of which 52 (39%) countries/territories achieved a decrease in DALYs of more than 50%, and 27 (52%) of the 52 were from sub-Saharan Africa. The concentration curves of the age-standardized DALY rates of HIV/AIDS were above the equality line from 2000 to 2019. The CI rose from -0.4625 (95% CI -0.6220 to -0.2629) in 2000 to -0.4122 (95% CI -0.6008 to -0.2235) in 2019. A four-phase trend of changes in the CIs of age-standardized DALY rates for HIV/AIDS was observed across 2000 to 2019, with an average increase of 0.6% (95% CI 0.4 to 0.8, P <0.001).
Conclusions: Globally, the burden of HIV/AIDS has decreased over the past two decades, accompanied by a trend of narrowing cross-country inequalities of HIV/AIDS burden. Moreover, the burden of HIV/AIDS continues to fall primarily in low-income countries.
WITHDRAWN: Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis
Authors: Li Guanqun , Liu Liwei , Sui Yuhang , Lu Tianqi , Wang Yongwei , Zhang Tao , Xie Yu , Xiao Peng , Zhao Zhongjie , Cheng Chundong , Hu Jisheng , Chen Hongze , Xue Dongbo , Chen Hua , Wang Gang , Kong Rui , Tan Hongtao , Bai Xuewei , Li Zhibo , McAllister Florencia , Li Le , Sun Bei 
Published: January 2023

Abstract
Hypertriglyceridemic pancreatitis (HTGP) is featured by higher incidence of complications and poor outcomes. Dysbiosis of gut microbiota has been established in HTGP, the impact of gut microbiota in pancreatic injury remains unclear. We observed that HTGP patients’ gut microbiota involved lower diversity and loss of beneficial bacteria, which were negatively correlated with local and systemic complications. In FMT mouse model, colonization with gut microbiota from HTGP patients exacerbated pancreatic injury through inducing neutrophil infiltration and neutrophil extracellular traps (NETs) compared to mice colonized with health volunteers’ fecal samples. Furthermore, decreased Bacteroides uniformis was demonstrated to trigger neutrophils accumulation and NETs release in HTGP, and oral administration of Bacteroides uniformis increased taurine production that alleviated pancreatic injury. In addition, taurine supplementation limited neutrophils infiltration and NETs that attenuated pancreatic injury. Notably, circulating NETs-related biomarker levels were elevated in HTGP patients and coculturing patients’ serum with neutrophils accelerated NETs release in vitro, accompanying with taurine-producing disorder. Our ﬁndings establish roles of endogenous Bacteroides uniformis-derived taurine suppressed neutrophils recruitments and NETs in HTGP, which provides potential insights of ameliorating pancreatic injury by gut microbiota modulation.
Expression and Regulatory Roles of Small Nucleolar RNA Host Gene 4 in Gastric Cancer
Authors: pourghasem navid , Ghorbanzadeh Shadi , nejatizadeh azim 
Published: January 2023

Abstract
Background
Gastric cancer is one of the leading causes of cancer death worldwide. Studies have shown that lncRNAs have a regulatory function in human diseases, particularly cancers. Small nuclear RNA host gene 4 (SNHG4) has known as an oncogenic long noncoding RNA (lncRNA) in various cancers, and its dysregulation can lead to tumorigenesis and cancer progression.
Methods
The present study aims to determine the molecular mechanism of SNHG4 and the effects of its expression on the development of GC. Based on the bioinformatics investigations, we studied gene expression analysis, Kaplan-Meier survival, Gene ontology (GO), KEGG pathway enrichment, microRNA targets, transcription factor targets, and proteins interacting with SNHG4. During the experimental phase, SNHG4 expression was examined by quantitative real-time PCR (qRT-PCR) in 40 paired gastric adenocarcinoma tissues and normal neighboring tissues. Also, we investigated the correlation between SNHG4 expression and patients' clinicopathological characteristics.
Results
Increased SNHG4 expression was detected in GC tissues, which is significantly associated with the TNM stage, grade group, tumor size, and metastatic status. Evaluation survival analysis demonstrated that overexpression of SNHG4 in GC tissues is remarkably related to poor overall survival (OS). SNHG4 is closely related to miR-490 and E2F family transcription factors. GO analysis suggested the possible role of SNHG4 in cell-cell adhesion, and KEGG enrichment analysis revealed that SNHG4 could be associated with the gastric cancer signaling pathway. ELAVL1 and IGF2BP2 have the highest number of SNHG4 target sites, and these proteins are involved in the PI3K-Akt-mTOR and ERK-MAPK signaling pathways.
Conclusions
Based on our results, we conclude that SNHG4 may have a function in GC development by regulating tumor-related signaling pathways.
Student participation at the UNFCCC Convention of the Parties supports transformational learning and engagement on climate action
Authors: Snorek Julie , Gilmore Elisabeth 
Published: January 2023

Abstract
When Swedish climate activist Greta Thunberg addressed world leaders at the United Nations Framework Convention on Climate Change (UNFCCC)’s 24th Conference of Parties (COP24), it was clear that young people are interested in and aware of their potential to influence international climate change negotiations. Young people also face barriers to effectively engaging in the COP processes with few opportunities to learn about the structure and practices for COP Observers. In this paper, we describe and evaluate a structured learning experience developed to support students conducting research related to climate change and their engagement with international climate negotiations. Before attending the COP24, students were given in-person and online training about the UNFCCC, its processes, and major issues under negotiation. They also developed and presented their work during a side event. Through pre- and post-surveys and in-depth interviews, we asked students about their expectations and degree of engagement and agency at the COP and more broadly on climate action. Students reported that the academic scaffolding before and during the COP provided them with tools for navigating the complexities of the COP. Despite the disengagement of some students, findings reveal that this learning experience supported self-efficacy and engagement in climate change action.
Upregulated expression of DACT1 and CYCLIN D1 have co-expression positive correlation in patients with colorectal cancer
Authors: ghasemian Majid , bazl masoumeh rajabi , Poodineh Jafar , Sadeghi Hossein , Razavi Amirnader Emami , Mirfakhraie Reza 
Published: January 2023

Abstract
Background: Aberrant activation of Wnt pathway is linked to dysregulation of several genes. DACT1 and DACT2 are members of the DACT family that participate in antagonizing of the Wnt signaling cascade. Thus in this study we assess the mRNA levels of DACT1, DACT2 and Cyclin D1 in CRC tissues compared to adjacent tissues.
Methods: Determination of the mRNA levels of DACT1, DACT2and Cyclin D1 was done by Quantitative Real-Time PCR (qRT-PCR). The correlation between DACT1, DACT2 and Cyclin D1 genes was examined. Receiver operating characteristic (ROC) curves was plotted to assess the diagnostic power. The association between histopathological parameters and the DACT1, DACT2 and Cyclin D1 gene was investigated.
Results: The levels of DACT1 and Cyclin D1 were remarkably higher in CRC tissue than adjacent tissues (P<0.0001). However, the expression of DACT2 was decreased (P<0.001). Between DACT1 and Cyclin D1 expression levels have a positive correlated (P<0.0001). DACT1 (AUC = 0.74, P<0.0001), DACT2 (AUC = 0.69, P<0.0003) and Cyclin D1 (AUC = 0.75, P<0.0001) had good effectiveness in separation between CRC samples and control. We found a significant association between DACT1 expression with tumor site (P <0.01). Also, a significant association was detected between DACT2 and Cyclin D1 with tumor stage (P <0.005 and P <0.038 respectively).
Conclusion: The findings suggested that DACT1 could function as an oncogene and correlation of DACT1 with Cyclin D1 expression suggests that DACT1expression is related to CRC progression whereas DACT2 was frequently downregulated and can be considered as a tumor suppressor.
What Stay-At-Home Orders Reveal About Dependence on Transportation Network Companies
Authors: Hanig Lily , Nock Destenie , Harper Corey D. 
Published: January 2023

Abstract
Transportation Network Companies (TNC) such as Uber and Lyft set out to provide transportation not fulfilled by private vehicles or public transit. The social value of TNCs for essential trips (i.e., necessary trips that cannot be fulfilled by another mode of transportation) is difficult to discern in normal conditions. The COVID-19 stay-at-home order is used as a natural experiment to investigate the heterogeneous ability to avoid TNCs by income areas of trip origins. We measure the sensitivity of different populations’ ability to respond to policies and to avoid TNC trips (e.g., early stay-at-home orders) using a difference-in-difference style regression. Previous studies have indicated that TNCs primarily serve high-income areas; however, we find that during the pandemic, TNCs contributed to transportation equity by servicing unavoidable trips to higher degrees in low-income areas. High-income community areas showed greater sensitivity to the stay-at-home order with a 56% greater decrease in TNC ridership during the stay-at-home order compared to low-income community areas. Specifically, TNC trips from high-income areas decreased by 80%. This indicates that low-income community areas are less able to adapt to stay-at-home orders because of a higher degree of non-flexible and essential jobs or worse access TNC alternatives like private vehicles and public transit.
When Geometric Deep Learning Meets Pretrained Protein Language Models
Authors: Wu Fang , Xu Jinbo , Radev Dragomir , Tao Yu 
Published: January 2023

Abstract
Geometric deep learning has recently achieved great success in non-Euclidean domains, and learning on 3D structures of large biomolecules is emerging as a distinct research area. However, its efficacy is largely constrained due to the limited quantity of structural data. Meanwhile, protein language models trained on substantial 1D sequences have shown burgeoning capabilities with scale in a broad range of applications. Nevertheless, no preceding studies consider combining these different protein modalities to promote the representation power of geometric neural networks. To address this gap, we make the foremost step to integrate the knowledge learned by well-trained protein language models into several state-of-the-art geometric networks. Experiments are evaluated on a variety of protein representation learning benchmarks, including protein-protein interface prediction, model quality assessment, protein-protein rigid-body docking, and binding affinity prediction, leading to an overall improvement of 20\% over baselines and the new state-of-the-art performance.
Strong evidence indicates that the incorporation of protein language models' knowledge enhances geometric networks' capacity by a significant margin and can be generalized to complex tasks.
Genetically determined levels of mTOR-dependent circulating proteins and risk of multiple sclerosis
Authors: Zhang Yao-chen , Fan Keyi , Wang Qi , Hu Jing-xi , Wang Qian , Zhang He-yi , Song Shan , Zhao Rong , Qiao Jun , Zhang Sheng-Xiao 
Published: January 2023

Abstract
Background
Observational studies have reported an association between circulating levels of mammalian target of rapamycin (mTOR)-dependent circulating proteins and multiple sclerosis (MS). However, the casual association has not been fully elucidated. Mendelian randomization (MR) is used to overcome limitations inherent to observational studies and assess the causal association.
Methods
To explore the causal association between mTOR-dependent proteins (AKT, RP-S6K, eIF4E-BP, eIF4A, eIF4E, eIF4G, and PKC-α) and MS, summary statistics were obtained from GWAS meta-analysis of the International Multiple Sclerosis Genetics Consortium (47429 patients and 68374 controls) and the INTERVAL study (genetic associations with 2994 plasma proteins from 3301 healthy individuals). MR analysis and sensitivity analyses were conducted.
Results
Among seven selected mTOR-dependent proteins, the circulating level of PKC-α (OR = 0.90, 95%CI 0.82–0.98, P = 0.017) and RP-S6K (OR = 1.12, 95%CI 1.00-1.25, P = 0.045) were associated with MS risk, while no significant causation was found between other proteins (AKT, eIF4E-BP, eIF4A, eIF4E, eIF4G) and MS.
Conclusion
Molecules in the mTOR signaling pathway may bidirectionally regulate the occurrence and development of MS. PKC-α is a protective factor, while RP-S6K is a risk factor. They might be used as future therapeutic targets for screening high-risk individuals.
The Spatial evolution of Urban Cultural Landscapes and Influencing Factors: A Case Study of Museums in Shandong Province, China
Authors: Lu Guanyu , Sun Haiyan , Wei Tongfeng , Du Peng 
Published: January 2023

Abstract
Under the strategic background of cultural revitalization, it is of great significance to study the evolving characteristics and influencing factors of museums to promote the prosperity and development of urban culture. Take the museums in Shandong province as the research object, based on the data from 1983–2021, the study was conducted by using Kernel Density Analysis, Spatial Autocorrelation, and Geodetector to reveal the spatial and temporal evolutionary characteristics of museums and their influencing factors within the domain of Shandong province. The research found that: 1) the number of museums shows a growth trend and can be divided into four stages: starting, rapid development, small growth, and high-speed development; the difference in the number in each city has a gradient, showing dispersion characteristics in different gradients; museums of historical and cultural themes and non-state museums occupy the main position in terms of quantity, and the trend of diversification of museum types is highlighted. 2) the spatial distribution is the cluster, showing a pattern of one center and multiple centers coexisting; the global distribution has a strong spatial correlation, and local high and low clusters change significantly; the center of gravity is concentrated near the geometric center of Shandong Province in an inverted V-shape migration. 3) The spatial pattern of museums in Shandong Province is formed under the comprehensive influence of policy, tourism, economy, culture, and education factors. The study has certain significance for promoting the development of cultural undertakings in Shandong Province and improving regional cultural competitiveness.
Computer-aided affinity enhancement of a cross-reactive antibody against dengue virus envelope domain III
Authors: Jonniya Nisha Amarnath , Poddar Sayan , Mahapatra Subhasmita , Kar Parimal 
Published: January 2023

Abstract
The dengue virus (DENV), composed of four distinct but serologically related Flaviviruses,causes the most important emerging viral disease, with nearly 400 million infections yearly. Currently, there are no approved therapies. Although DENV infection induces lifelong immunity against the same serotype, the antibodies raised contribute to severe disease in heterotypic infections. Therefore, understanding the mechanism of DENV neutralization by antibodies is crucial in the design of vaccines against all serotypes. This study reports a comparative structural and energetic analysis of the monoclonal antibody Mab 4E11 in complex with its target domain III of the envelope protein for all four DENV serotypes. We use extensive replica molecular dynamics simulations in conjunction with the binding free energy calculations. Further single point and double mutations were designed through computational site-directed mutagenesis and observed that the re-engineered antibody exhibits high affinity to binding and broadly neutralizing activity against serotypes. Our results showed improved binding affinity by the gain of enthalpy, which could be attributed to the stabilization of salt-bridge and hydrogen bond interactions at the antigen-antibody interface. The findings provide valuable results in understanding the structural dynamics and energetic contributions that will be helpful to the design of high-affinity antibodies against dengue infections.