bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between breast nodules, anxiety, depression and metabolic risk factors in a Chinese cohort
Authors: Long Yan , Zhang Wei , Zheng Maolan , Xie Qian , Liu He , Hu Xiaotong , Zhang Xuelan , Huang Wei , Gao Xia , Jiang Chunmao , Jiang Can , Gao Dong , Deng Juan 
Published: May 2023

BackgroundThe relationship between anxiety, depression, and metabolic parameters and the incidence of breast nodules is unclear. This study aims to investigate the association between female breast nodules and anxiety, depression and metabolic factors.MethodsThis cross-sectional study recruited 857 individuals with biological indicators and breast ultrasound data from the Daping hospital from April 2021 to February 2022. Serum samples were used to measure fasting blood glucose, uric acid, triglycerides, total cholesterol, urea nitrogen, alanine transaminase, aspartate transaminase, albumin, high-density lipoprotein, low-density lipoprotein. Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess the level of anxiety and depression.ResultThe positive rate of breast nodules in women aged 40 to 49 years old was significantly higher than that of other age women. The proportion of participants aged 40–49 years old in the group with breast nodules was significantly higher than that in the group without breast nodules (34.6% vs. 16.9%, p&lt;0.001). Breast nodules in postmenopausal women were significantly lower than those in premenopausal women (26.4% vs. 73.6%, p = 0.026). The SAS scores of women with breast nodules were higher than those of the no-nodules group (40.99 ± 8.45 vs. 38.94 ± 6.89, p&lt;0.001), same as the SDS scores (41.97 ± 10.33 vs. 38.91 ± 7.60, p &lt; 0.001). The number of women suffering from anxiety in the group of breast nodules was significantly higher than that in control (13.8% vs. 4.5%, p &lt; 0.001), and the number of depression in the group of breast nodules was also significantly higher than that of in control (14.4% vs. 4.5%, p &lt; 0.001). Women with breast nodules showed a slightly lower uric acid level than those without breast nodules (290.11 ± 65.32 vs. 301.43 ± 65.93 umol/L, p = 0.016). Multivariable logistic regression analysis showed that age, menopausal status, anxiety and depression status were significantly associated with the presence of breast nodules, but there was no significant difference in uric acid.ConclusionOur findings offer insight into the occurrence of depression and anxiety in the breast nodules of Chinese women. Anxiety and depression status, age and menopausal status may be the independent risk factors for the occurrence of breast nodules.
Factors related with nursing students’ health literacy: a cross sectional study
Authors: Ramón-Arbués Enrique , Granada-López José Manuel , Antón-Solanas Isabel , Cobos-Rincón Ana , Rodríguez-Calvo Antonio , Gea-Caballero Vicente , Tejada-Garrido Clara Isabel , Juárez-Vela Raúl , Echániz-Serrano Emmanuel 
Published: May 2023

BackgroundNursing professionals have a crucial role in promoting health literacy in health services, so it is necessary to ensure health literacy skills in future health professionals.ObjectiveThe objective of the study was to examine the health literacy of nursing students and its associated factors.MethodsA cross-sectional descriptive study was carried out on 460 nursing students. For data collection, a semi-structured questionnaire was obtained on sociodemographic characteristics, perception and health care, use of the health system and lifestyles. In addition, health literacy was assessed using the European Health Literacy Questionnaire.Results6.1% of the participants had an inadequate level of health literacy and 36.5% problematic. The probability of having sufficient health literacy is directly associated with age; and inversely with smoking, prolonged screen time and living alone (p &lt; 0.05).ConclusionA large percentage of nursing students need to improve their health literacy skills. It is necessary to integrate a greater number of contents in health literacy in the curriculum of nursing students.
Association between multimorbidity and falls and fear of falling among older adults in eastern China: a cross-sectional study
Authors: You Liuqing , Guo Lihua , Li Na , Zhong Jieming , Er Yuliang , Zhao Ming 
Published: May 2023

BackgroundGrowing evidence has reported an association between multimorbidity and falls and fear of falling (FOF) in older adults, however, the results regarding this association from China are limited. Our study aimed to investigate the association between multimorbidity and falls and FOF in older adults in eastern China.MethodsWe conducted a cross-sectional study in Zhejiang Province, Eastern China, which recruited a provincial representative sample of adults aged ≥ 60 years. A structured questionnaire including demographic characteristics, chronic diseases, history of falls in the past 12 months, and FOF, was administered by all participants. The exposure variable was multimorbidity, which was defined as the presence of two or more chronic diseases and medical conditions in the same individual. The outcomes included a history of falls and FOF. Multivariate logistic regression was used to evaluate the association between multimorbidity and falls and FOF in older adults.ResultsIn total of 7,774 participants were included in the analysis, among whom 3,898 (50.1%) were female, with a mean ± standard deviation age is 72.9 ± 8.4 years. Multimorbidity was associated with the increased risk of falling in older adults [adjusted odds ratio (OR), 1.99; 95% confidence interval (CI):1.55–2.36]. The ORs for having experienced single fall and repeated falls were 1.85 (95% CI: 1.42–2.42) and 3.45 (95% CI: 1.47–6.97), respectively, with multimorbidity compared with those without chronic diseases. The older adults with multimorbidity were more likely to report FOF compared with those without chronic diseases (adjusted OR, 1.49; 95%CI:1.30–1.70). Moreover, the association between multimorbidity and FOF remained significant in the older adults with a history of fall (OR, 1.57; 95%CI:1.04–2.38).ConclusionThe association between multimorbidity and falls and FOF is significant in the Chinese population and the effects of multimorbidity on falls and FOF do not vary according to the frequency and history of falls in older adults.
Complete lumbarization with calcified disc herniations at L5S1 and S1-2 levels treated with percutaneous endoscopic interlaminar discectomy: a case report and technique note
Authors: Lisheng Hou , Feng Ge , Dong Zhang , Tianjun Gao , Shaokui Nan , Xuedong Bai , Qing He 
Published: May 2023

ObjectiveThis study aims to report a case of a patient with complete lumbarization (Castellvi-IB) who developed symptomatic calcified disc herniations at L5S1 and lumbarized S1-2 levels and achieved excellent neurological recovery following percutaneous endoscopic interlaminar discectomy (PEID).Summary of Background DataIn 1984, Castellvi et al. classified lumbosacral transitional vertebra (LSTV) into four types. They incorrectly classified I LSTV anomalies as only type I sacralization, not realizing type I lumbarization also belonged to type I LSTV, with the latter exhibiting a well-developed S1-2 disc (lumbosacral transitional disc, LSTD). Patients with type I lumbarization rarely develop calcified disc herniations concomitantly at L5S1 and LSTD levels. PEID has been developed to perform discectomy for neurological decompression at the lumbar region, especially at the lowest level where the higher iliac crest and/or widened transverse process exists.MethodsA 47-year-old male presented to our hospital complaining of an intractable left leg radiating pain for 3 weeks after suffering from chronic radiating pain for 4 years. His physical examination found hyperalgesia at the lateral side of the left calf, decreased dorsal flexion strength of the ankle (grade 4/5), and a positive sign of straight leg raising test at the left side (30°). The preoperational Lumbar JOA (Japanese Orthopaedic Association) score was 12. Image examinations including whole spinal radiograph, MRI, and CT confirmed complete lumbarization (Castellvi-IB) with calcified disc herniations at L5S1 and LSTD levels at the left side. PEID was carried out at two index levels to accomplish decompression via the left approach.ResultsThe patient’s neurological function recovered quickly. One day postoperatively, he began to walk without discomfort. After 3 months, his muscle strength recovered to normal, and after 6 months, the residual dysesthesia at his posterolateral calf disappeared. The follow-up Lumbar JOA score was 26.ConclusionCalcified lumbar disc herniation could develop at two distal levels concomitantly in the case of type I complete lumbarization. This anomaly might be misinterpreted as a normal lumbar sequence by only lumbar MRI. PEID may be an effective procedure to treat such calcified disc herniations in a single visit.
Tumor budding as a predictor of disease-free survival in patients with cholangiocarcinoma
Authors: Kim Kyung Bin , Ahn Ji Hyun , Kwon Soon Wook , Lee Su Ji , Lee Yury , Park Seo Young , Kim Ahrong , Choi Kyung Un , Lee Chang Hun , Huh Gi Yeong 
Published: May 2023

Background: Tumor budding is considered a prognostic factor in several solid cancer types. However, we lack comprehensive information on the importance of tumor budding in cholangiocarcinoma. Therefore, we aimed to assess the prognostic value of tumor budding in intrahepatic and extrahepatic cholangiocarcinomas and to evaluate its correlations with other clinicopathological parameters.Methods: We monitored 219 patients who underwent surgery for intrahepatic or extrahepatic cholangiocarcinoma at the Pusan National University Hospital between 2012 and 2021. Tumor budding was evaluated using the International Tumor Budding Consensus Conference scoring system. Tumor budding was classified into low (0–4), intermediate (5–9), and high (≥10). For statistical analysis, tumor budding was divided into two groups based on the cut-off value of 10 (lower: 0–9 vs. higher: ≥10). The correlations between clinicopathological parameters were examined using the chi-square and Fisher’s exact test. The prognostic values of the variables were analyzed using the log-rank test and Cox regression analysis.Results: Low, intermediate, and high tumor buddings were identified in 135 (61.6%), 63 (28.8), and 21 (9.6%), patients, respectively. Higher tumor budding was related to the presence of lymphatic invasion (p = 0.017), higher tumor grade (p = 0.001), higher N category (p = 0.034). In the univariable and multivariable analyses, higher tumor budding was associated with shorter disease-free survival in 97 (44.3%) patients who underwent R0 resection (p &lt; 0.001 and p = 0.011). Tumor budding did not significantly correlate with disease-specific survival in entire patients.Conclusion: Tumor budding may serve as a prognostic factor for intrahepatic and extrahepatic cholangiocarcinomas treated with R0 resection.
Design, Synthesis, In Vitro Antifungal Activity and Mechanism Study of the Novel 4-Substituted Mandelic Acid Derivatives
Authors: Chen Biao , Song Dandan , Shi Huabin , Chen Kuai , Wu Zhibing , Chai Huifang 
Published: May 2023

Plant diseases caused by phytopathogenic fungi are a serious threat in the process of crop production and cause large economic losses to global agriculture. To obtain high-antifungal-activity compounds with novel action mechanisms, a series of 4-substituted mandelic acid derivatives containing a 1,3,4-oxadiazole moiety were designed and synthesized. In vitro bioassay results revealed that some compounds exhibited excellent activity against the tested fungi. Among them, the EC50 values of E13 against Gibberella saubinetii (G. saubinetii), E6 against Verticillium dahlia (V. dahlia), and E18 against Sclerotinia sclerotiorum (S. sclerotiorum) were 20.4, 12.7, and 8.0 mg/L, respectively, which were highly superior to that of the commercialized fungicide mandipropamid. The morphological studies of G. saubinetii with a fluorescence microscope (FM) and scanning electron microscope (SEM) indicated that E13 broke the surface of the hyphae and destroyed cell membrane integrity with increased concentration, thereby inhibiting fungal reproduction. Further cytoplasmic content leakage determination results showed a dramatic increase of the nucleic acid and protein concentrations in mycelia with E13 treatment, which also indicated that the title compound E13 could destroy cell membrane integrity and affect the growth of fungi. These results provide important information for further study of the mechanism of action of mandelic acid derivatives and their structural derivatization.
SOCIAL FACTORS OF MENTAL HEALTH AND WELL-BEING OF OLDER RUSSIANS
Authors: Маркеева А.В. , Синяков А.В. 
Published: May 2023

В статье на основе результатов волновых социологических исследований ощущаемого качества жизни за 2002–2019 гг. и авторского репрезентативного обследования пожилых россиян в 2022 г. выделены социальные факторы ментального здоровья и благополучия пожилых россиян. Возраст, гендер и занятость выступают наиболее значимыми детерминантами не только социальной активности, но ментального здоровья и эмоционального благополучия. При этом в ходе исследования показано, что пандемия оказала разнонаправленное влияние на ощущаемое качество жизни у пожилых россиян. В сравнении с допандемийной ситуацией, после смягчения ограничительных мер, параметр социальной активности существенно вырос, параметр ментального здоровья практически не изменился, а вот эмоциональные проблемы пожилые россияне стали чувствовать острее. Жесткие ограничения для старшего возраста, длительный период изоляции, необходимость работающим пенсионерам перестраивать свою работу в дистанционном формате, стрессы, тревога, беспокойство — все это сказывалось на повседневной жизни пожилых.
The article highlights social factors of mental health and well-being of older Russians based on the results of wave sociological studies of the perceived quality of life for 2002–2019 and the author’s representative survey of older Russians in 2022. Age, gender and employment are the most signifi cant determinants not only of social activity, but also of mental health and emotional well-being. At the same time, the study shows that the pandemic had a multidirectional impact on perceived quality of life among older Russians. Compared to the prepandemic situation, after the relaxation of restrictive measures, the parameter of social activity increased signifi cantly, the parameter of mental health remained virtually unchanged, but the emotional problems of elderly Russians became more acute. Due to the severe restrictions for older people, the long period of isolation, and for working pensioners — also due to the need to restructure their work remotely — stress, anxiety and worry have affected everyday life.
CAPILLARY BLOOD FLOW MORPHOFUNCTIONAL READJUSTMENTS IN NORTHERNERS OF DIFFERENT AGES
Authors: Аверьянова И.В. , Вдовенко С.И. 
Published: May 2023

Морфофункциональные показатели капиллярного кровотока можно рассматривать как один из наиболее чувствительных маркеров онтогенетических дезадаптивных изменений как на уровне локального участка капиллярной сети, так и в сердечно-сосудистой системе в целом. Для выявления возрастной динамики морфофункциональных характеристик капиллярного русла было проведено обследование 277 мужчин 18–66 лет — жителей Севера. Установлена значимая возрастная динамика, проявляющаяся в уменьшении диаметра артериального и переходного отделов микрокапиллярного русла в ряду от юношей к лицам пожилого возраста. При этом коэффициент ремоделирования значимо возрастал у мужчин трудоспособного и пожилого возраста, что свидетельствует о риске снижения эффективности диффузии веществ. Наблюдаемое в данном возрастном векторе возрастание средней длины капилляра можно рассматривать как компенсаторное увеличение контактной поверхности сосуда, направленное на поддержание необходимого уровня транскапиллярного обмена. Данные микроциркуляторные изменения, отчетливо прослеживающиеся с увеличением возраста обследованных мужчин, свидетельствуют об адаптивной перестройке микроангиоархитектоники, что может указывать на формирование характерного паттерна онтогенетических перестроек у жителей-северян.
Morphofunctional characteristics of capillary blood fl ow can be considered one of the most sensitive markers of ontogenetic desadaptive changes both within a local area of the capillary network and in the entire cardiovascular system. The study involved two hundred seventyseven male northerners aged 18–66 to identify the age dynamics of the capillary bed morphofunctional characteristics. Subjects exhibited a reduction in diameters of arterial and transitional sections of the microcapillary bed testifying to a signifi cant age dynamics from young men to the elderly. The remodeling coeffi cient increasingly came up in workable and elderly men, which indicated the risk of reducing in effectiveness of substances diffusion. We could see the average capillary length increase in this age vector and considered that as a compensatory growth of the contact surface of the vessel aimed at maintaining the necessary level of transcapillary exchange. We clearly observed microcirculatory changes with subjective age and considered them to be adaptive changes of microangioarchitectonics which may indicate the formation of a pattern characteristic of northerners’ ontogenetic readjustments.
EFFECT OF PHARMACOLOGICAL STIMULATION OF MELATONIN RECEPTORS ON RENAL FUNCTION IN AGING
Authors: Жукова О.В. , Виноградова И.А. , Горанский А.И. 
Published: May 2023

Цель исследования — изучение ионного обмена, а также водо- и азотовыделительной функции почек у крыс под влиянием фармакологической стимуляции мелатониновых рецепторов. Эксперимент был проведен на крысах-самцах, которые были разделены на две группы: 1-я — контрольная (n=35), содержалась в стандартных условиях вивария; 2-я — на протяжении всей жизни получала мелатонин вместе с питьевой водой (n=35). Исследование проведено с соблюдением международных принципов Хельсинкской декларации о гуманном отношении к животным. По анализу крови и мочи определяли потребление воды, объем диуреза, содержание креатинина, мочевины, ионов натрия и калия в моче и крови. На основании полученных данных рассчитывали параметры водно-солевого обмена. Полученные в результате исследования данные подвергали статистической обработке. В результате эксперимента отмечено снижение функциональных способностей почек у крыс как в контрольной группе, так и в группе животных, получавших мелатонин. Однако анализ данных показывает, что крысы, получавшие мелатонин, имели более высокие показатели водовыделительной, ионорегулирующей и азотовыделительной функций почек по сравнению с интактными животными. Таким образом, длительное применение экзогенного мелатонина приводило к более стабильному функционированию почек и водно-солевого обмена у старых животных в сравнении с контрольной группой.
The aim of the study was to study ion exchange, as well as water and nitrogen excretion function of the kidneys in rats under the infl uence of pharmacological stimulation of melatonin receptors. The experiment was conducted on male rats, which were divided into 2 groups. The fi rst group was a control group (n=35) and was kept in standard vivarium conditions. Animals of the second group received melatonin along with drinking water throughout their lives (n=35). The study was conducted in compliance with the international principles of the Helsinki Declaration on Humane Treatment of Animals. According to the blood and urine analysis, water consumption, the volume of diuresis, the content of creatinine, urea, sodium and potassium ions in urine and blood were determined. Based on the data obtained, the parameters of water-salt metabolism were calculated. The data obtained as a result of the study were subjected to statistical processing. As a result of the experiment, a decrease in the functional abilities of the kidneys was noted in rats both in the control group and in the group of animals treated with melatonin. However, data analysis shows that rats treated with melatonin had higher values of indicators of water-releasing, ion-regulating and nitrogen-releasing kidney functions compared with intact animals. Thus, long-term use of exogenous melatonin led to more stable functioning of the kidneys and water-salt metabolism in old animals compared with the control group.
FEATURES OF CD68+ AND CD163+ EXPRESSION IN THE URINARY BLADDER AS A MARKER OF CANCER IN AGE ASPECTS
Authors: Павлова Т.В. , Прощаев К.И. , Павлов И.А. , Бессмертный Д.В. , Пилькевич Н.Б. , Павлова Л.А. , Османова Н.А. 
Published: May 2023

В исследовании представлено изучение экспрессии CD68+ и CD163+ в мочевом пузыре как маркера рака в возрастных аспектах. В рамках выполненной работы были обследованы 35 пациентов 36– 70 лет с раком мочевого пузыря с гистологической верификацией заболевания. Изменение уровня экспрессии CD68+ и CD163+ в клетках моноцитарного происхождения может трактоваться как показатель диагностических параметров активности тканевых макрофагов и эндотелиальных клеток при раке. Их прогрессия при онкогенезе особенно ярко выражена в группе пациентов среднего возраста. В пожилом возрасте наблюдали снижение данных параметров, что свидетельствует в пользу уменьшения активности развития онкологических процессов с возрастом. Сочетание морфологического и иммунологического атипизма приводит к нарушению функциональной специализации органа.
The study presents a study of the expression of CD68+ and CD163+ in the bladder as a marker of cancer in age-related aspects. As part of the work performed, 35 patients with bladder cancer with histological verifi cation of the disease aged 36 to 70 years were studied. The role of CD68+ and CD163+ cells in bladder reactions can be interpreted as an indicator of diagnostic parameters of the activity of tissue macrophages and endothelial cells in cancer. Their progression during oncogenesis is especially pronounced in the group of middle-aged patients. In old age, there is a decrease in these parameters, which indicates in favor of a decrease in the activity of the development of oncological processes with age. The combination of morphological and immunological atypism leads to a violation of the functional specialization of the organ.