bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of entrepreneurial intentions on depression: the mediating role of job insecurity and moderating roles of person vocation fit, and entrepreneurial leadership in the longitudinal study
Authors: Shabeer Sobia 
Published: July 2023

PurposeThe understanding regarding the impact of entrepreneurial intentions on the job insecurity and depression is limited in the longitudinal settings, organizations need to know which factors can be added to decrease the psychological and career issues of visiting or contract employees. Thus, this research aims to investigate the person vocation fit and entrepreneurial leadership as a moderator in the relation of entrepreneurial intentions, job insecurity and depression in within- and between-person level with the time of 4 months' time lag.Design/methodology/approachThe data was gathered by using survey method from visiting faculty of universities located in Punjab, in the longitudinal design of 4-wave months and M.plus software was used to do the mediation and moderation analysis.FindingsResults revealed that job insecurity mediated the entrepreneurial intentions and depression, the person vocation fit and entrepreneurial leadership moderated the entrepreneurial intentions and job insecurity link in the following month.Research limitations/implicationsThis paper contributes in the literature of entrepreneurship and career management, by considering the role of person vocation fit and entrepreneurial leadership in the organizations of emerging countries that have high unemployment rate and mental health issues. This paper provides nuanced understanding of how these two constructs have influenced the entrepreneurial intentions-job insecurity-depression within- and between-person level in the visiting or contract employees. Therefore, made strong contribution to the theory of person- environment fit, the entrepreneurial event theory and the contingency theory in the longitudinal data. In addition, to generalize the results, this theoretical framework should be tested in the other geographic area and industries.Practical implicationsThe findings give practitioners, e.g. managers, policy- makers and counselors, with an idea how to decrease the feelings of job insecurity and depression in visiting or contract employees. They can promote the culture of innovation by giving training of entrepreneurial leadership and hiring the employees who have person vocation fit, all of these factors can lead to enhance the positive organizational image in potential and existing employees as well as it will also decrease the unemployment issue in emerging countries.Originality/valueIn past, scholars focused on the consequences of job insecurity and its harms but none emphasized on the aspects of entrepreneurship regarding the visiting faculty of universities. Like how entrepreneurial intentions can gradually decrease the job insecurity and depression among them and how the strengthen of person vocation fit and entrepreneurial leadership role their play monthly in this regard.
Examining the impacts of social media on the psychological well-being in a patriarchal culture: a study of women in Pakistan
Authors: Aksar Iffat Ali , Firdaus Amira , Gong Jiankun , Anwar Pasha Saadia 
Published: July 2023

PurposeThe unstoppable and exponential growth of social media use has given rise to concerns about the consequent effects on users. Among the major concerns are the psychological consequences, which have received considerable academic attention. The current mixed-methods research aims to examine women's social media use and its effects on their psychological well-being in a patriarchal culture, namely Pakistan.Design/methodology/approachThis study employs a mixed-method research methodology. The quantitative section collected data from 240 women and used structural equation modelling to test the proposed hypotheses. Thematic analysis was used to analyse the in-depth interviews with ten women.FindingsThe integration of the findings revealed increased use of social media by women and its beneficial effects (communication and socialisation, escapism and self-presentation), though qualitative findings revealed the cultural implications and obstacles that women face (online anonymity and digital asylum). The study calls attention to women's social media usage patterns and the resulting effects on women's psychological well-being in a low-income country with a patriarchal social structure.Originality/valueMost research remains limited to Western societies and young populations. The situation is somewhat different in developing economies with traditionally preserved cultures compared to Western societies. This study uniquely examines the influence of social media on psychological well-being in a developing country with a special cultural context.
Factors in the development of smart villages regarding tourism in the Baltic states
Authors: Dembovska Iveta , Klavinska Antra , Dimanta-Svilpe Zanda , Raupeliene Asta 
Published: July 2023

PurposeThis study aims to examine the nature of smart villages and the factors in their development in relation to the tourism industry in the Baltic states.Design/methodology/approachThis research employed theoretical literature analysis to conceptualize the factors contributing to smart village development, discourse analysis (analysis of good smart village branding practice), a qualitative approach and descriptive analysis to analyse semi-structured expert survey e-questionnaires to identify the nature of smart villages, as well as to analyse factors in the development of smart villages in relation to tourism in the Baltic states. Specialists who represent tourism, other businesses and the discipline of economics were chosen as experts.FindingsThe experts indicated that the development of smart villages can contribute to essential and important factors in the development of tourism such as the growth of a creative economy, the development of community culture, values, traditions and symbols, the production of local food, the establishment of unique natural, cultural and recreational objects, as well as improvement in infrastructure and the introduction of new technologies.Originality/valueThe study contributes to an understanding of the development of smart villages, given the important factors that were examined. The smart village approach is a relatively new approach to sustainable rural development and tourism promotion. In Europe, it is a better-known approach to developing local areas and tourism, yet each region has its own distinctive features.
Sampling effect in predicting the evolutionary response of populations to climate change
Authors: Aguirre‐Liguori Jonás A. , Morales‐Cruz Abraham , Gaut Brandon S. , Ramírez‐Barahona Santiago 
Published: July 2023

AbstractGenomic data and machine learning approaches have gained interest due to their potential to identify adaptive genetic variation across populations and to assess species vulnerability to climate change. By identifying gene–environment associations for putatively adaptive loci, these approaches project changes to adaptive genetic composition as a function of future climate change (genetic offsets), which are interpreted as measuring the future maladaptation of populations due to climate change. In principle, higher genetic offsets relate to increased population vulnerability and therefore can be used to set priorities for conservation and management. However, it is not clear how sensitive these metrics are to the intensity of population and individual sampling. Here, we use five genomic datasets with varying numbers of SNPs (NSNPs = 7006–1,398,773), sampled populations (Npop = 23–47) and individuals (Nind = 185–595) to evaluate the estimation sensitivity of genetic offsets to varying degrees of sampling intensity. We found that genetic offsets are sensitive to the number of populations being sampled, especially with less than 10 populations and when genetic structure is high. We also found that the number of individuals sampled per population had small effects on the estimation of genetic offsets, with more robust results when five or more individuals are sampled. Finally, uncertainty associated with the use of different future climate scenarios slightly increased estimation uncertainty in the genetic offsets. Our results suggest that sampling efforts should focus on increasing the number of populations, rather than the number of individuals per populations, and that multiple future climate scenarios should be evaluated to ascertain estimation sensitivity.
Carbon‐ion radiotherapy for oligometastatic liver disease: A national multicentric study by the Japan Carbon‐Ion Radiation Oncology Study Group (J‐CROS)
Authors: Shiba Shintaro , Wakatsuki Masaru , Toyama Shingo , Terashima Kazuki , Uchida Hirofumi , Katoh Hiroyuki , Shibuya Kei , Okazaki Shohei , Miyasaka Yuhei , Ohno Tatsuya , Tsuji Hiroshi 
Published: July 2023

AbstractReports on the therapeutic efficacy and safety of carbon‐ion radiotherapy (C‐ion RT) for oligometastatic liver disease are limited, with insufficient evidence. This study aimed to evaluate the clinical outcomes of C‐ion RT for oligometastatic liver disease at all Japanese facilities using the nationwide cohort data. We reviewed the medical records to obtain the nationwide cohort registry data on C‐ion RT between May 2016 and June 2020. Patients (1) with oligometastatic liver disease as confirmed by histological or diagnostic imaging, (2) with ≤3 synchronous liver metastases at the time of treatment, (3) without active extrahepatic disease, and (4) who received C‐ion RT for all metastatic regions with curative intent were included in this study. C‐ion RT was performed with 58.0–76.0 Gy (relative biological effectiveness [RBE]) in 1–20 fractions. In total, 102 patients (121 tumors) were enrolled in this study. The median follow‐up duration for all patients was 19.0 months. The median tumor size was 27 mm. The 1‐year/2‐year overall survival, local control, and progression‐free survival rates were 85.1%/72.8%, 90.5%/78.0%, and 48.3%/27.1%, respectively. No patient developed grade 3 or higher acute or late toxicity. C‐ion RT is a safe and effective treatment for oligometastatic liver disease and may be beneficial as a local treatment option in multidisciplinary treatment.
Clinical, microbiological and osteoimmunological findings in different peri‐implant conditions – A cross‐sectional study
Authors: Jezdic Marija , Nikolic Nadja , Krasavcevic Ana Djinic , Milasin Jelena , Aleksic Zoran , Carkic Jelena , Jankovic Sasha , Milinkovic Iva 
Published: July 2023

AbstractObjectivesThe aim of this study was to assess the prevalence of certain microbiota and their potential correlation with clinical parameters, expression of proinflammatory cytokines, Notch signalling pathway molecules and bone remodelling mediators among different peri‐implant conditions.Materials and MethodsIncluded participants had at least one dental implant minimally 1 year in function. They were divided into peri‐implantitis (PI), peri‐implant mucositis (PM) and healthy implants (HIs) groups. Prevalence of P. ginigvalis, Fusobacterium spp., EBV and C. albicans was detected in participants' crevicular fluid (CF) using quantitative real‐time polymerase chain reaction, different markers' expression, as well as clinical data, were correlated with the microbial presence.ResultsCF samples taken from one chosen implant from each of the 102 participants were analyzed. Significantly higher levels of P. gingivalis were found in PI compared with HI (p = .012) and PM (p = .026). Fusobacterium spp. was also more prevalent in PI (p = .041) and PM (0.008) than in HI. P. gingivalis was a predictor of PPDi (p = .011, R2 = 0.063) and CALi (p = .049, R2 = 0.038). A positive correlation was found in PI for the level of Fusobacterium spp. and TNFα expression (ρ = 0.419, p = .017) while in PM, P. gingivalis and Notch 2 expression were correlated (ρ = 0.316, p = .047).ConclusionsP. gingivalis appears to be involved in the osteolysis in patients with PI, while the positive correlation of its level with Notch 2 expression in patients with PM suggests a potential involvement of P. gingivalis in the progression of PM into PI.
Altered large‐scale individual‐based morphological brain network in spinocerebellar ataxia type 3
Authors: Su Shu , Sha Runhua , Qiu Haishan , Chu Jianping , Lin Liping , Qian Long , Hu Manshi , Wu Chao , Cheung Gerald L. , Yang Zhiyun , Chen Yingqian , Zhao Jing 
Published: July 2023

AbstractBackgroundAccumulating evidences indicate regional gray matter (GM) morphology atrophy in spinocerebellar ataxia type 3 (SCA3); however, whether large‐scale morphological brain networks (MBNs) undergo widespread reorganization in these patients remains unclear.ObjectiveTo investigate the topological organization of large‐scale individual‐based MBNs in SCA3 patients.MethodsThe individual‐based MBNs were constructed based on the inter‐regional morphological similarity of GM regions. Graph theoretical analysis was taken to assess GM structural connectivity in 76 symptomatic SCA3, 24 pre‐symptomatic SCA3, and 54 healthy normal controls (NCs). Topological parameters of the resulting graphs and network‐based statistics analysis were compared among symptomatic SCA3, pre‐symptomatic SCA3, and NCs groups. The inner association between network properties and clinical variables was further analyzed.ResultsCompared to NCs and pre‐symptomatic SCA3 patients, symptomatic SCA3 indicated significantly decreased integration and segregation, a shift to “weaker small‐worldness”, characterized by decreased Cp, lower Eloc, and Eglob (all p < 0.005). Regarding nodal properties, symptomatic SCA3 exhibited significantly decreased nodal profiles in the central executive network (CEN)‐related left inferior frontal gyrus, limbic regions involving the bilateral amygdala, left hippocampus, and bilateral pallidum, thalamus; and increased nodal degree, efficiency in bilateral caudate (all pFDR <0.05). Meanwhile, clinical variables were correlated with altered nodal profiles (pFDR ≤0.029). SCA3‐related subnetwork was closely interrelated with dorsolateral cortico‐striatal circuitry extending to orbitofrontal‐striatal circuits and dorsal visual systems (lingual gyrus‐striatal).ConclusionSymptomatic SCA3 patients undergo an extensive and significant reorganization in large‐scale individual‐based MBNs, probably due to disrupted prefrontal cortico‐striato‐thalamo‐cortical loops, limbic‐striatum circuitry, and enhanced connectivity in the neostriatum. This study highlights the crucial role of abnormal morphological connectivity alterations beyond the pattern of brain atrophy, which might pave the way for therapeutic development in the future.
Prognostic value of preoperative thyroid autoantibodies for post‐thyroidectomy patient pathology: A retrospective cohort study
Authors: Al‐Angari Samiah S. , AlAngari Hussam S. , Al‐Dhahri Saleh F. 
Published: July 2023

AbstractObjectiveThe aim of this study was to evaluate the clinical value of preoperative thyroid autoantibodies with reference to the post‐thyroidectomy patient pathology.DesignA retrospective cohort study.SettingTwo tertiary care academic hospitals.Materials and MethodsA total of (n = 473) subjects who underwent thyroidectomy from 2009 to 2019 were included. Preoperative serum thyroid autoantibodies (anti‐thyroglobulin [anti‐Tg] and anti‐thyroperoxidase [anti‐TPO]) were measured, and the potential predictors of postoperative pathological diagnosis (age, gender, and thyroid autoantibodies) were assessed using multivariable regression models.ResultsPatients with positive thyroid autoantibodies were more likely to have malignant disease than benign disease; adjusted odds ratio (AOR) = 1.6 (1.3–2.7, p = 0.002) for anti‐Tg, and AOR = 1.6 (1.1–2.5, p = 0.027) for anti‐TPO. A subset analysis of the same predictors performed on patients with cancer (malignant vs. microcarcinoma) showed that patients with ages ≥40 were more likely to develop microcarcinoma as opposed to malignant disease; AOR = 1.8 (1.1–3.1, p = 0.03) for anti‐TPO, and AOR = 1.7 (1.0–2.9, p = 0.04) for anti‐Tg.ConclusionPreoperative thyroid autoantibodies could be used clinically to predict the risk of malignancy in thyroid nodules, thus helping guide treatment decisions in patients with thyroid nodules and speeding up the decision to undergo surgical intervention.
The macroeconomic impact of automation: Applications to elderly care
Authors: Lu Chia‐Hui 
Published: July 2023

AbstractWhen automation technology can both help a firm's production and be widely used in the provision of long‐term care for the elderly, developments in automation can potentially help alleviate the situation of a declining birthrate in an aging society and increase production and household welfare. In addition, this paper obtains results consistent with the real‐world situation in which population aging and a declining birthrate arise simultaneously. Considering the case where automation technology is developed by firms does not change the main findings. Therefore, the government should encourage people to engage in the development of automation.
Long‐term effects of air pollution on hospital admissions and mortality for chronic obstructive pulmonary disease in Beijing, China
Authors: Zhu Rui‐xia , Chen Jin 
Published: July 2023

AbstractObjectiveWe aimed to clarify the association between air pollution and hospital admissions for chronic obstructive pulmonary disease (COPD) and mortality in Beijing, China.MethodsIn this retrospective study, we recruited 510 COPD patients from 1 January 2006 to 31 December 2009. The patient data were obtained from the electronic medical records of Peking University Third Hospital in Beijing. Air pollution and meteorological data were obtained from the Institute of Atmospheric Physics of the Chinese Academy of Sciences. Monthly COPD hospital admissions, mortality and air pollution data were analysed using Poisson regression in generalised additive models adjusted for mean temperature, pressure and relative humidity.ResultsThere were positive correlations between sulfur dioxide (SO2), particulate matter with an aerodynamic diameter ≤ 10 μm (PM10) and COPD hospital admissions in the single‐pollutant model. An increase of 10 μg/m3 in SO2 and PM10 were associated with an increase of 4.053% (95% CI: 1.470–5.179%) and 1.401% (95%CI: 0.6656–1.850%) in COPD hospital admissions. In the multiple‐pollutant model [SO2 and nitrogen dioxide (NO2) combinations], there was only a positive correlation between SO2 and COPD hospital admissions. An increase of 10 μg/m3 in SO2 were associated with an increase of 1.916% (95% CI: 1.118–4.286%) in COPD hospital admissions. There was no correlation between three pollutant combinations and COPD hospital admissions.We did not find correlations between air pollution and COPD mortality in either single‐ or multiple‐pollutant models.ConclusionsSO2 and PM10 may be important factors for the increase in COPD hospital admissions in Beijing, China.
Multicenter study of universal prophylaxis versus pre‐emptive therapy for patients at intermediate risk (R+) for CMV following heart transplantation
Authors: Lerman Joseph B. , Green Cynthia L. , Molina Maria R. , Maharaj Valmiki , Ortega‐Legaspi Juan M. , Sen Sounok , Flattery Maureen , Maziarz Eileen K. , Shah Keyur B. , Martin Cindy M. , Alexy Tamas , Shah Palak , Morris Alanna A. , DeVore Adam D. , Cole Robert T. 
Published: July 2023

AbstractIntroductionHeart transplant (HT) recipients with prior exposure to cytomegalovirus (CMV R+) are considered intermediate risk for CMV‐related complications. Consensus guidelines allow for either universal prophylaxis (UP) or preemptive therapy (PET) (serial CMV testing) approaches to CMV prevention in such patients. Whether an optimal approach to mitigate CMV related risks exists in this setting remains uncertain. We therefore assessed the utility of PET as compared to UP in CMV R+ HT recipients.MethodsRetrospective analysis of all CMV R+ HT recipients from 6 U.S. centers between 2010 and 2018 was performed. The primary outcome was the development of CMV DNAemia or end‐organ disease resulting in the initiation/escalation of anti‐CMV therapy. The secondary outcome was CMV‐related hospitalization. Additional outcomes included incidence of acute cellular rejection (ACR) ≥ grade 2R, death, cardiac allograft vasculopathy (CAV), and leukopenia.ResultsOf 563 CMV R+ HT recipients, 344 (61.1%) received UP. PET was associated with increased risk for the primary (adjusted HR 3.95, 95% CI: 2.65–5.88, p < .001) and secondary (adjusted HR 3.19, 95% CI: 1.47–6.94, p = .004) outcomes, and with increased ACR ≥ grade 2R (PET 59.4% vs. UP 34.4%, p < .001). Incidence of detectable CAV was similar at 1 year (PET 8.2% vs. UP 9.5%, p = .698). UP was associated with increased incidence of leukopenia within 6 months post‐HT (PET 34.7% vs. UP 43.6%, p = .036).ConclusionThe use of a PET CMV prophylaxis strategy in intermediate risk HT recipients associated with increased risk of CMV infection and CMV‐related hospitalization, and may associate with worse post‐HT graft outcomes.
Optimizing expert and patient input in pediatric trial design: Lessons learned and recommendations from a collaboration between conect4children and European Patient‐CEntric ClinicAl TRial PLatforms
Authors: Dhaenens Britt A. E. , Mahler Fenna , Batchelor Hannah , Dicks Pamela , Gaillard Segolene , Nafria Begonya , Kopp‐Schneider Annette , Ribeiro Maria Alexandra , Schwab Matthias , Sparber‐Sauer Monika , Leubner Jonas , de Wildt Saskia N. , Oostenbrink Rianne 
Published: July 2023

AbstractAdvice from multiple stakeholders is required to design the optimal pediatric clinical trial. We present recommendations for acquiring advice from trial experts and patients/caregivers, derived from advice meetings that were performed through a collaboration of the Collaborative Network for European Clinical Trials for Children (c4c) and the European Patient‐CEntric ClinicAl TRial PLatforms (EU‐PEARL). Three advice meetings were performed: (1) an advice meeting for clinical and methodology experts, (2) an advice meeting for patients/caregivers, and (3) a combined meeting with both experts and patients/caregivers. Trial experts were recruited from c4c database. Patients/caregivers were recruited through a patient organization. Participants were asked to provide input on a trial protocol, including endpoints, outcomes, and the assessment schedule. Ten experts, 10 patients, and 13 caregivers participated. The advice meetings resulted in modification of eligibility criteria and outcome measures. We have provided recommendations for the most effective meeting type per protocol topic. Topics with limited options for patient input were most efficiently discussed in expert advice meetings. Other topics benefit from patient/caregiver input, either through a combined meeting with experts or a patients/caregivers‐only advice meeting. Some topics, such as endpoints and outcome measures, are suitable for all meeting types. Combined sessions profit from synergy between experts and patients/caregivers, balancing input on protocol scientific feasibility and acceptability. Both experts and patients/caregivers provided critical input on the presented protocol. The combined meeting was the most effective methodology for most protocol topics. The presented methodology can be used effectively to acquire expert and patient feedback.