bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deriving a Measure for the Environmental Quality of Life of an Ultra-Dense Urban Setting
Authors: CHEN Si 
Published: August 2023

Abstract
Quality of life (QOL) is a multidimensional term that encompasses all social, economic, and environmental aspects. While social and economic indicators are readily available in standard census statistics, there is no consensus on environmental indicators due to the broad range of measures available. Environmental aspects of QOL vary depending on the physical setting (spatial), satisfaction (rating), and preference (value). Physical settings can be objectively measured, but rating and value involve personal judgment. This study proposes a measure of the physical environment that allows for flexibility in adjusting personal preferences. The study area consisted of 89 neighborhoods in Hong Kong, representing different degrees of urbanization, that were spatially spread out. The spatial unit of a neighborhood was fixed at 800m x 800m to ensure consistent and meaningful comparisons. The study utilized Geographic Information System (GIS) and Remote Sensing (RS) methods to process four domains of urban morphological characteristics at the neighborhood level from digital maps, aerial photographs, and satellite images: (i) education-health-recreation facilities, (ii) street patterns, (iii) compatible land use diversity, and (iv) building density. Principal Component Analysis was used to further reduce the dimensionality of each domain and derive an Environmental Quality Sub-index (EQ-I) that can be standardized and adjusted based on personal value and preference. The neighborhood EQ-I enables both quantitative and qualitative comparisons through visual graphics. This study illustrates a methodological approach to collapsing multiple variables into a single index and accounting for the differential contribution of weights based on value preference. The method employs direct and objective measures that can be adapted and replicated in other cities to offer standardized yet personalized scores for regional and international comparisons.
Novel non-toxic technology of sperm selection for ICSI comply with WHO strict normal criteria for stained sperm cells
Authors: Michailov Yulia , Nemerovsky Luba , Ghetler Yehudith , Finkelstein Maya , Schonberger Oshrat , Wiser Amir , Raziel Arie , Saar-Ryss Bozhena , Ami Ido Ben , Kaplanski Olga , Miller Netanella , Herzberger Einat Haikin , Friedler Yardena Mashiach , Levitas-Djerbi Tali , Amsalem Eden , Umanski Natalia , Tamadaev Valeria , Ovadia Yaniv S. , Peretz Aharon , Sacks Gilat , Naava Dekel , Odelya Zaken , Levi Mattan 
Published: August 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
A Size Filter Regulates Apical Protein Sorting
Authors: Macara Ian , de Caestecker Christian 
Published: August 2023

Abstract

Despite decades of research, apical sorting of epithelial membrane proteins remains incompletely understood. We noted that apical cytoplasmic domains are smaller than those of basolateral proteins; however, the reason for this discrepancy is unknown. We investigated whether a size barrier at the trans-Golgi network (TGN) might hinder apical sorting of proteins with large cytoplasmic tails. We focused on Crb3 and Ace2 as representative apical proteins with short cytoplasmic tails. By incorporating a streptavidin-binding peptide, these proteins can be trapped in the endoplasmic reticulum (ER) until addition of biotin, which triggers synchronous release to the Golgi and subsequent transport to the apical cortex. Strikingly, departure from the Golgi could be significantly delayed simply by increasing cytoplasmic bulk. Moreover, large and small Crb3 segregated into spatially distinct Golgi regions as detected by super resolution imaging. Biologically, Crb3 forms a complex through its cytoplasmic tail with the Pals1 protein, which could also delay departure, but although associated at the ER and Golgi, we found that Pals1 disassociates prior to Crb3 departure. Notably, a non-dissociable mutant Pals1 hampers the exit of Crb3. We conclude that an unexpected mechanism involving a size filter at the TGN facilitates apical sorting of proteins with small cytoplasmic domains and that timely release of Pals1, to reduce cytoplasmic domain size, is essential for the normal kinetics of Crb3 sorting.
Genetic link between celiac disease and autoimmune liver diseases: A two-sample Mendelian randomization study
Authors: Zhou Zhiyi , Mou Xuanting , Chen Jun , Zhou Yujie , Xu Xiao 
Published: August 2023

Abstract
Objective: Although previous epidemiological studies have reported an association between Celiac disease (CeD) and Autoimmune liver disease (AILD), the causal relationship between them remains unclear. This study aimed to assess the bidirectional causal relationship between CeD and AILD using Mendelian randomization (MR).
Methods: We obtained genome-wide association study (GWAS) datasets of CeD, PBC and PSC of thoroughly European ancestry from the IEU GWAS database and GWAS of AIH from GWAS Catalog. MR analyses were performed with inverse variance weighted (IVW), MR-Egger and weighted median methods.
Results: Positive causal effects of genetic predisposition to CeD on PSC (IVW OR = 1.16, 95% CI = 1.04-1.29, p = 0.0095) and AIH (IVW OR = 1.09, 95% CI = 1.02-1.17, p = 0.0126) were derived, with no causal effect on PBC. The results of reverse MR analysis demonstrated that genetic susceptibility to PBC was associated with an increased risk of CeD (IVW OR = 1.09, 95% CI = 1.01-1.17, p = 0.0267).
Conclusion: This study reveals a causality of CeD on PSC and AIH and PBC on CeD among patients of European descent. It differs slightly from previous observational studies, suggesting that the mechanisms of interaction between AILD and CeD needs further exploration.
Formation of chirality in propagating spin waves
Authors: Trevillian Cody , Tyberkevych Vasyl 
Published: August 2023

Abstract
A general approach to quantify chirality, or absence of parity symmetry, of spin waves has been developed and applied to spin waves propagating in obliquely magnetized ferromagnetic films. Using theoretical arguments and numerical calculations, it is shown that, upon increasing spin wave wavevector, initially achiral spin waves develop chiral properties through the “parity exchange” mechanism, which implies, in particular, that chiral spin waves appear in pairs. The most striking example of the parity exchange mechanism is the simultaneous formation of two chiral waves: the magnetostatic surface wave and the recently discovered heterosymmetric spin wave, which were previously considered independent of each other. Another manifestation of the parity exchange is the formation of strongly chiral waves near the anti-crossings of spin wave branches of unequal symmetry. These findings illustrate viable paths to engineering spin wave systems with prescribed chiral spectra that had not previously been considered.
Unleashing the Relationship Between Financialization and Natural Resource Wealth in India: Evaluating the Blessing or Curse Paradigm
Authors: SINGH SONALI 
Published: August 2023

Abstract
Countries in their early phases of development rely heavily on natural resources. This study employs consistent data from 1971 to 2019 to test India's “Financial Resource Curse” utilizing various rent generated from natural resources, trade openness, domestic investment, and subsequent influence on financial growth. The study employs three structural breaks of 1991,2008,2016, which are expected to affect the Indian economy. The study uses an ARDL bounding test to achieve its objective, which works well in different-order integrated variables; it estimates long-run and short-run estimates. Additionally, “Impulse Response Function (IRF)” and “Variance Decomposition Analysis” were generated using “VAR Decomposition Analysis (VDA)”. According to the findings, trade openness contributes to financial progress in the short run. Initial levels of OR, TOT, MIR, and MR tend to increase FD with time. The results support the idea that a country's “Forest Resource Blessing” boosts economic activity while retaining income. CR decreases FD, initially reassuring the FRC hypothesis. Long-term trade openness declines and gross fixed capital formation adversely affect India's financial growth, as shown by the financial resource curse and the adverse effects of NR rents on that development. The NARDL model is additionally employed in this study to examine the asymmetries between natural resource development and financial development. The results show that natural resource adverse shocks positively impact financial development, confirming that financial growth rises in tandem with increased natural resource adverse shocks in the short period “Resource-Positive” shocks boost a nation's financial progress over time.
Synergistic effect of carbon nanotube on improving thermal stability, flame retardancy and electrical conductivity of poly(butylene succinate)/piperazine pyrophosphate composites
Authors: Wang Yiming , Meng Fanjing , Zhu Junling , Ba Zhaotian , Jiang Dayong , Wen Xin , Tang Tao 
Published: August 2023

Abstract
Biodegradable poly (butylene succinate) (PBS) is considered as promising material for replacing conventional nondegradable polymers in various engineering fields, but its applications are limited by inherent flammability and low electrical conductivity. In this study, the synergistic effect of carbon nanotube (CNTs) on improving thermal stability, flame retardancy and electrical conductivity of poly(butylene succinate)/piperazine pyrophosphate (PBS/PAPP) composites was investigated. Thermogravimetric analysis (TGA) demonstrated that the addition of CNTs could improve the thermal stability of PBS/PAPP composites, where the maximum mass loss temperature (Tmax) of PBS/18PAPP-2CNT increased by 9.1 oC in comparison with that of PBS/20PAPP. Meanwhile, PBS/18PAPP-2CNT exhibited the optimal flame retardancy with limited oxygen index (LOI) of 30.1%, V0 rating in UL-94 vertical burning test and 79.6% reduction on the peak of heat release rate (PHRR) in cone calorimeter test. The synergistic effect of CNTs and PAPP was beneficial to form high-quality char layer, resulting in the enhanced flame retardancy of PBS. Furthermore, the CNTs could improve the electrical conductivity of PBS/PAPP composites with low percolation threshold of 1.75 wt%, which was ascribed to the “volume excluded effect” of PAPP. Thus, the current work provided an efficient strategy to prepare multifunctional PBS composites to meet various engineering applications.
Current Design of Rectangular Steel Silos: Limitations and Improvement
Authors: Hilal AlHussein , Sanad A. M. , Abdelbarr Mohamed H. , Ramadan Osman M. O. , Abdalla Hany A. 
Published: August 2023

Abstract
This study proposes a modification for the current design approach for rectangular silos that accounts of silos’ wall flexibility. First, the authors investigated the effect of wall stiffness, symbolized by the wall width-to-thickness ratio (a/t), on the wall-filling pressure using a recently validated 3D finite element model (F.E.M.). The model was then employed to predict the pressures acting on flexible-wall silos accounting for the stress state in stored granular materials. Most design formulas and guidelines assume silos’ walls to be rigid. This assumption is acceptable for the case of thick-wall concrete silos; it is questionable for thin-wall, metal silos, however. Consequentially, it is crucial to determine the minimum wall stiffness necessary to secure the applicability of the current design rigid wall assumption, and to propose a way to deal with more flexible walls. To this end, several wall pressure distributions that correspond to filling steel silos with varied wall thicknesses were studied. A new adjustment to the Janssen technique was proposed for a better estimate of the wall-filling pressures for square or rectangular silos. In the case of square silos, the Eurocode uses the Janssen equation together with an equivalent radius of a corresponding circular silo (with the same hydraulic radius) to determine the wall pressure. This method predicts pressure values that are practically accurate for rigid-wall silos, but its accuracy decreases for flexible-wall silos. As a remedy, the Janssen equation was modified in this research to generate more accurate pressure estimates based on the equivalent volume concept. The finite element results of several developed models with the same granular material were compared to the estimations of the newly established approach to verify the broad range of its applicability.
Global streamflow modelling using process-informed machine learning
Authors: Magni Michele , Sutanudjaja Edwin H. , Shen Youchen , Karssenberg Derek 
Published: August 2023

Abstract
We present a novel hybrid framework that incorporates information from the process-based global hydrological model PCR-GLOBWB, to reduce prediction errors in streamflow simulations. In addition to catchment attributes and meteorological data, our methodology employs simulated streamflow and state variables from PCR-GLOBWB as predictors of observed river discharge. These outputs are used in a random forest, trained on a global database of streamflow measurements, to improve estimates of simulated river discharge across the globe. PCR-GLOBWB was run for the years 1979–2019 at 30 arcmin and its inputs and outputs were upscaled from daily to monthly time steps. A single random forest model was trained with these state variables, meteorological data and catchment attributes, as predictors of observed streamflow at 2,286 stations worldwide. Model performance was evaluated using Kling–Gupta efficiency (KGE). Results based on cross-validation show that the model is capable of discerning between a variety of hydroclimatic conditions and river flow dynamics, improving KGE of PCR-GLOBWB simulations at more than 80% of testing locations and increasing median KGE from −0.03 in uncalibrated runs to 0.51 after post-processing. Performance boosts are usually independent of the availability of streamflow data, making our method a potential candidate in addressing prediction in poorly gauged and ungauged basins.
Assessment of the Initial Result of Screw Fixation for Proximal Crescentic Metatarsal Osteotomy with Distal Soft Tissue Reconstruction in Severe Hallux Valgus Treatment
Authors: Mao Haijiao , Wang Linger , Yao Liwei , Dong Wenwei 
Published: August 2023

Introduction:
Proximal crescentic metatarsal osteotomy and distal soft tissue reconstruction have been introduced to correct severe HV. The intrinsically unstable proximal first crescentic osteotomy depends on enough force fixation for stability. It is necessary to judge the number of fixation screws for osteotomy.

Method:
Fifty-two feet of 50 adult patients with severe HV were included in this study. The treatment was proximal crescentic metatarsal osteotomy with a single screw and distal soft tissue reconstruction in Group 1 and the fixation with two screws with distal soft tissue reconstruction in Group 2. Clinical and radiological follow-ups were assessed after 4 and 12 months of operation. In Group 1, HVA decreased from 46.4 ±3.28 to 19.9 ±4.70 after 12 months of operation and from 45.1 ±3.45 to 19.1 ±4.70 in Group 2. Regarding the intermetatarsal angle (IMA) in Group 1, it was changed from 18.5 ±1.98 to 9.25 ±1.11 after 12 months of operation. For group 2, it decreased from 18.3 ±1.81 to 9.53 ±1.70. Meanwhile, the AOFAS score improved from 63.1 to 83.9 after 12 months of operation in Group 1 and improved from 64.3 to 82.8 in Group 2.

Results:
Furthermore, the VAS score reduced from 4.5±1.01 to 1.7± 0.43 in Group 1 and from 4.7±0.92 to 1.7±0.55 in Group 2 after 12 months of operation. There were no significant differences identified between Group 1 and Group 2 in terms of VAS and AOFAS scores and HVA and IMA measurements.

Conclusion:
There is less complication in two-screw fixation for crescentic osteotomy compared to a single-screw fixation.
Amphotericin-B-Induced Chronic Kidney Disease in a Post-COVID-19
Patient with Widespread Rhinocerebral Mucormycosis and Pneumonia:
A Case Report
Authors: Johri Nishant , Choudhary Ambika , Rawat Ujjawal , Vengat Maheshwari 
Published: August 2023

Background:
The COVID-19 pandemic has posed a unique challenge to the medical
community due to potential co-infections with bacteria and fungi. We report a case of Rhino
cerebral mucormycosis infection in a 67-year-old patient after recovery from COVID-19.

Objective:
To report a case of Rhino cerebral mucormycosis in a 67-year-old patient with preexisting
health conditions after recovering from COVID-19 and to highlight the importance of early
detection and treatment of co-infections in patients with pre-existing health conditions.

Case Presentation:
The patient had pre-existing health conditions, including uncontrolled diabetes,
hypertension, and Chronic obstructive pulmonary disease (COPD), which made him more vulnerable
to complications after COVID-19. He was admitted to the hospital after experiencing a dark
discharge from his left eye, later confirmed to be due to mucormycosis. Histopathological examination
revealed invasive mucormycosis, highlighting the importance of early detection and treatment.
However, the patient experienced Acute kidney injury (AKI) after only 5 days of treatment
with conventional amphotericin B, underscoring the need for careful monitoring and adjustment of
treatment regimens.

Discussion:
The case underscores the need for early detection and treatment of co-infections in
vulnerable patients. The patient's pre-existing conditions and immunocompromised state made him
more susceptible to the infection. The case also highlights the importance of careful monitoring
and adjustment of treatment regimens to minimize the risk of adverse effects.

Conclusion:
While COVID-19 has presented challenges and uncertainties, it has also provided
valuable insights into the interactions between infectious agents and the human body. Continued
research and vigilance are necessary to mitigate the impact of co-infections and improve outcomes
for patients.
Analysis of Government Expenditure Response, Foreign Direct Investment, Human Development Index and Inclusive Economic Growth in Indonesia
Authors: Ilmi Marina  , Satrianto Alpon 
Published: August 2023

This study aims to analyze the response to shocks that occur between the variables Government Expenditure, Foreign Investment, Human Development Index, and Inclusive Economic Growth. This type of research is descriptive and inductive. The data used are panel data for 34 provinces in Indonesia from 2012-2020, data obtained from related agencies. The analysis method used is the Panel Vector Error Correction Model (PVECM). The results of this study show that: (1) The response to government expenditure in the education function due to the shock of inclusive economic growth is positive, (2) The response to government expenditure in the health function due to the shock of inclusive economic growth is positive (3) The response to government expenditure in the economic function due to the shock of inclusive economic growth is negative (4) The response of foreign investment due to the shock of inclusive economic growth is negative (5) The response of the human development index due to the presence of Shock of Inclusive Economic Growth Is Positive.
Corazón que ríe, corazón que llora, de Maryse Condé: una lectura desde la literatura poscolonial, el feminismo y el psicoanálisis
Authors: Blanco-Ramos Roberto Antonio 
Published: August 2023

Se analiza la obra Corazón que ríe, corazón que llora. Cuentos verdaderos de mi infancia, de la escritora guadalupana Maryse Condé mediante tres vertientes teóricas y metodológicas que responden a una lógica deconstructiva. Se refiere a la literatura poscolonial, el psicoanálisis y el feminismo afrodescendiente. El examen realizado permite establecer determinaciones significativas sobre la construcción histórica literaria de la narrativa poética de la autora y la representación del legado de la colonialidad del poder en términos de raza, saberes de poder, resistencia y género. Metodológicamente, desde las teorías y perspectivas poscoloniales se analiza discursivamente la obra. Se concluye que el texto de la autora ayuda a comprender la configuración de procesos de resignificación fundamentada por medio de un compromiso sociopolítico y en la identificación de una feminidad negra resignificada.
E-Book Berdasarkan Model Pembelajaran Berbasis Proyek pada Mata Kuliah Media Pembelajaran
Authors: Simamora Alexander Hamonangan , Jampel Nyoman , Tegeh I Made 
Published: August 2023

Bahan ajar yang dipergunakan masih terbatas pada buku ajar cetak yang selama ini memiliki banyak keterbatasan. Hal ini berdampak pada kurangnya motivasi mahasiswa dalam belajar dan berpengaruh pada hasil belajar yang rendah. Tujuan penelitian ini yaitu mengembangkan E-book berbasis proyek pada mata kuliah media pembelajaran. Penelitian ini merupakan penelitian pengembangan yang merujuk pada model pengembangan ADDIE (Analysis, Desain, Development, Implementation, Evaluation). Subjek penelitian ini yaitu 2 orang ahli yang meliputi ahli media pembelajaran dan desain pembelajaran. Subjek uji coba produk yaitu 3 orang mahasiswa sebagai subjek uji perorangan, 12 mahasiswa (kelompok kecil). Metode pengumpulan data menggunakan observasi, kuesioner, dan tes. Instrument yang digunakan dalam mengumpulkan data yaitu kuesioner. Teknik yang digunakan untuk menganalisis data yaitu analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian yaitu penilaian yang diberikan oleh ahli media pembelajaran E-book berbasis proyek memperoleh nilai persentase 97,5% (sangat baik). Hasil penilaian yang diberikan oleh ahli desain pembelajaran yaitu 95,4% (sangat baik). Hasil penilaian uji coba perorangan yaitu 90% (sangat baik). Hasil penilaian uji coba kelompik kecil yaitu 93,7% (sangat baik). Dapat disimpulkan bahwa E-book berbasis proyek pada mata kuliah media pembelajaran layak digunakan dalam pembelajaran. Dosen dapat menggunakan E-book berbasis proyek untuk meningkatkan semangat belajar mahasiswa.
Media Video Animasi Pada Mata Pelajaran Pendidikan Agama Hindu dan Budi Pekerti
Authors: Dewi Nia Satyawati , Parmiti Desak Putu , Sukmana Adrianus I Wayan Ilia Yuda 
Published: August 2023

Proses pembelajaran daring memiliki banyak kendala dari berbagai sudut pandang, misalnya mengenai materi. Guru kurang mampu membuat materi inovatif yang menggunakan lingkungan belajar online. Hal ini berdampak pada pembelajaran yang tidak berjalan optimal. Tujuan kajian ini adalah untuk menciptakan media video animasi pada mata pelajaran Pendidikan Agama Hindu dan Budi Pekerti. Jenis penelitian ini yaitu pengembangan menggunakan model pengembangan ADDIE. Subjek penelitian adalah 1 pakar isi mata pelajaran, 1 pakar desain pembelajaran, 1 pakar media pembelajaran, 3 pelajar percobaan individual dan 10 pelajar percobaan kelompok kecil. Metode pengumpulan data dengan kuesioner. Teknik analisis data yang digunakan yaitu analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian yaitu media video animasi dikatakan valid dengan hasil penilaian pakar isi mata pelajaran diperoleh kualifikasi sangat baik sebesar 93,3%, validitas uji pakar desain pembelajaran sebesar 88,3% diperoleh kualifikasi baik, pakar media pembelajaran mendapat skor 94,6%, diperoleh kualifikasi sangat baik, uji coba individual mendapat nilai 95,99% diperoleh kualifikasi sangat baik, dan uji coba kelompok kecil mendapat nilai 96,32% diperoleh kualifikasi sangat baik. Disimpulkan bahwa media video animasi mata pelajaran Pendidikan Agama Hindu dan Budi Pekerti dapat digunakan karena dinilai baik dan sangat baik.