bluuebunny/crossref_metadata_2025_split huggingface dataset:
Handlungsoptionen zur Krisen-Resilienz
Authors: von Eiff Maximilian C. , von Eiff Wilfried , Ghanem Mohamed 
Published: December 2022

Zusammenfassung
Ziel Über die Qualität des Pandemiemanagements in
Deutschland existiert ein kontroverses Meinungsbild. Vor diesem Hintergrund ist
es angezeigt, Fehler und Versäumnisse des Pandemiemanagements sachlich
zu reflektieren und konstruktiv Maßnahmen zur Stärkung der
Resilienz ausgewählter Bereiche des Gesundheitssystems (Lieferketten,
Digitalisierung, Fachkräfteverfügbarkeit, Versorgungsstruktur,
Refinanzierung) zu entwickeln.
Methode Durchgeführt wurde eine Meta-Analyse verschiedener Studien
über die medizinische Versorgungssituation während der Pandemie,
ergänzt durch eine Analyse von Lieferabrissen bei Medizinprodukten und
Arzneimitteln sowie eine Recherche über die Arbeitssituation und
Arbeitszufriedenheit von „am Bett tätigen
Berufsgruppen“. Die Datenerhebung erfolgte durch Literaturanalyse,
anonymisierte Fragebogen und strukturierte Interviews mit Entscheidern
unterschiedlicher Funktionsbereiche (z. B. Einkauf/Logistik,
Medizin/Pflege).
Ergebnisse Die Resilienz von Lieferketten steigt durch teilweise
Rückverlagerung systemkritischer Produkte und verstärkte
Orientierung am Kriterium „Liefersicherheit“ bei der Auswahl von
Partnern und Standorten.Telemedizinische Dienste zur Betreuung von Patienten im häuslichen
Bereich und digitale Behandlungs-Plattformen für virtuelle Arztbesuche
bewirken Kontaktreduktion im Pandemiefall, verhindern medizinische
Spätfolgen und volkswirtschaftliche Kosten unterlassener
Vorsorgeuntersuchungen, nutzen knappe Arzt-Ressourcen effizienter und
erhöhen die Verfügbarkeit medizinischer Leistungen in der
Fläche.Die Vergütung medizinischer Leistungen sollte auf die Prinzipien des
Value-Based Health Care-Ansatzes umgestellt und durch eine
funktionsabhängige Finanzierung von Vorhaltekosten ergänzt
werden.Die Schaffung attraktiver Arbeitsbedingungen in Verbindung mit
arbeitgeberseitigen Unterstützungsmaßnahmen wie z. B.
kostenfreie 7/24-KiTa-Plätze und einer angemessenen
Vergütung stellt ein wirksames Maßnahmenbündel zur
Begegnung des Fachkräftemangels dar.
Schlussfolgerungen Es besteht dringender Handlungsbedarf, um die
Krisenresilienz des Gesundheitssystems für die Zukunft zu
stärken.Krankenhaus-Manager haben die Aufgabe, die Arbeitsbedingungen
familienfreundlicher zu gestalten und die Entgeltsituation für
„am Bett tätige Berufsgruppen“ nachhaltig zu verbessern,
um dem Fachkräftemangel entgegenzuwirken.Politik und Verbände sind gefordert, die Finanzierung von Vorhaltekosten
in das Vergütungssystem einzubauen, die Digitalisierung voranzutreiben
und für den Aufbau von heimischen Reserve-Produktionskapazitäten
bei systemkritischen Medizinprodukten sowie Arzneimitteln zu sorgen.Der Beitrag der Medizinindustrie liegt in der Verkürzung globaler
Lieferketten, um deren Steuerbarkeit zu erleichtern sowie deren
Versorgungssicherheit zu erhöhen. Die Entwicklung von nachhaltigen
Produkten verringert den Ressourcenbedarf, senkt die Kosten der
Betriebsbereitschaft, unterstützt die Klimaziele und reduziert das
Risiko von Lieferabrissen.
Einsatz von OTC-Arzneimitteln bei
SARS-CoV-2-Infektionen
Authors: Völkel Lukas , Seibel Jens , Rychlik Reinhard P. T. 
Published: December 2022

ZusammenfassungPublizierte Studien aus dem Jahr 2021 zeigen, dass Acetylsalicylsäure
(ASS) bei hospitalisierten Covid-19-Patienten zu einer Verbesserung des
Krankheitsverlaufs führen kann. Darauf aufbauend wurde mittels eines
Surveys eine retrospektive Datenerhebung von 866 Covid-19-Patienten, die eine
Behandlung mit OTC-Arzneimitteln erhielten, sowie deren Krankheitsverlauf
erhoben (2021/2022).Die Patientengruppe, die eine Behandlung mit ASS erhielt, war deutlich
älter und schwerer grunderkrankt als die Vergleichsgruppen an Patienten,
die entweder mit Ibuprofen, Paracetamol oder ohne OTC-Arzneimittel behandelt
wurden. Obwohl die SARS-CoV-2-Patienten mit ASS älter und schwerer
vorerkrankt sind, stellt sich der Behandlungsverlauf vergleichbar zu
jüngeren und leichter vorerkrankten Patienten dar. Symptome wie
Gliederschmerzen und Schüttelfrost wurden beispielsweise in der
Subgruppe (Behandlung mit Ibuprofen bzw. Paracetamol) häufiger
dokumentiert. Ebenso waren rein von den relativen Werten Patienten mit einer
ASS-Behandlung häufiger besser eingestellt, wenn es um ambulante
Behandlungen, Notfallbehandlungen, Krankenhauseinweisungen und
Facharztüberweisungen ging.Ein signifikanter Unterschied konnte bezüglich der ambulanten
Behandlungen und Notfallbehandlungen von Patienten mit einer ASS Behandlung im
Vergleich zu Patienten, die mit Paracetamol behandelt wurden, aufgezeigt werden.
Die Ergebnisse sind Indizien dafür, dass ASS bei älteren
Patienten mit SARS-CoV-2-Infektion, einen milderen Krankheitsverlauf
begünstigen kann.
Wie sind wir bisher durch die COVID-19-Pandemie gekommen? Ein
vergleichender Blick nach Europa
Authors: Bahnsen Lewe , Wild Frank 
Published: December 2022

ZusammenfassungDie Bewältigung der COVID-19-Pandemie hat weitreichende
Eindämmungsmaßnahmen erfordert. Um die Auswirkungen deutscher
Pandemiepolitik einzuordnen, kann ein europäischer Blick hilfreich sein.
Wir greifen das Konzept der Übersterblichkeit auf, um einen Eindruck vom
bisherigen Pandemieverlauf und implizit auch der Pandemiebewältigung in
den EU-27-Staaten und primär Deutschland zu gewinnen. Alles in allem ist
Deutschland bisher vergleichsweise gut durch die Pandemie gekommen. Dies
dürfte auch auf die ergriffenen Maßnahmen
zurückzuführen sein, deren Effektivität sich im
Einzelnen allerdings nicht feststellen lässt. Um kommenden Pandemien
vorbereitet zu begegnen, müssen klare Zuständigkeiten und
Entscheidungsstrukturen festgelegt und ein begleitendes Pandemiemonitoring
etabliert werden.
Erfahrungen des Gemeinsamen Bundesausschusses: Die Pandemie im Blick
behalten und zeitlich befristete Entscheidungen mit Augenmaß
treffen
Authors: Hecken Josef 
Published: December 2022

ZusammenfassungDie Corona-Pandemie stellte die gesamte Gesundheitsversorgung in Deutschland 2020
vor eine in dieser Dimension bisher nicht gekannte Herausforderung. Aufgrund
seiner Systemkenntnis und seiner Regelungsbefugnis konnte der Gemeinsame
Bundesausschuss die Rahmenbedingungen für Leistungserbringer,
Krankenkassen und Versicherte in Form von zeitlich befristeten Sonderregelungen
rechtssicher an das dynamische Pandemiegeschehen anpassen. Dabei agierte er
schnell, pragmatisch und mit Augenmaß – stets darauf abzielend,
die Balance zu halten zwischen einem in der Krise notwendigen Abweichen von
Richtlinien oder Beschlüssen und dem schrittweisen Zurückkehren.
Als Erkenntnis aus den letzten beiden Jahren lässt sich feststellen: Die
Politik hätte die Funktion des Gemeinsamen Bundesausschusses als
Verhandlungsarena intensiver nutzen können.
MoS2-Catalyzed Aerobic Synthesis of Tetraethylthiuram Disulfide in Batch and Continuous Flow
Authors: Wang Xiao , Zhao Ze-Run , Xu Hao-Xing 
Published: December 2022

Abstract:Tetraethylthiuram disulfide (TETD) is one of the most important thiuram-class rubber vulcanization accelerators and a ‘star molecule’ in other areas. The development of a mild, efficient, low-cost, safe, and sustainable approach to produce TETD is extremely desirable. Here, we developed a much-improved route to synthesize TETD using MoS2 as the catalyst and ethanol as the solvent. A packed-bed microflow strategy was implemented to accelerate the catalytic process. TETD was obtained with an excellent yield and purity within a short residence time. Besides, this continuous process did not generate any waste salts, rendering it a sustainable method for producing thiuram-type compounds.
Evaluation of the Effect of Repetitive Transcranial Magnetic Stimulation of Motor Cortex on Failed Back Surgery Syndrome Pain Control in the Short Term
Authors: Soltani Ahmad , Ghavipisheh Mahsa , Ardakani Ramin Manouchehri , Ahrari Iman , Salehi Sina , Farrokhi Majid Reza 
Published: December 2022

Abstract
Background This study aimed to evaluate the short-term efficacy of repetitive transcranial magnetic stimulation (rTMS) on the treatment of failed back surgery syndrome (FBSS).
Methods In this prospective clinical trial study, 13 patients with FBSS were selected to undergo rTMS, including 5 sessions of stimulation of the primary motor cortex of 90 trains with a frequency of 10 Hz for 2 seconds and an intertrain interval of 20 seconds with a total pulse rate of 1800 per session. The time of each session was 30 minutes with an intensity of 80% of the motor threshold. The severity of pain before and after the intervention was measured by the short-form McGill Pain Questionnaire and visual analog scale (VAS).
Results The mean of pain severity was 26.54 ± 6.78 and 14.92 ± 10.1 before and after rTMS, respectively. The severity of pain was significantly decreased after the intervention (p = 0.001). According to the McGill Pain Questionnaire, the severity of pain in the patients was decreased by 44.09 ± 27.32. The mean of the severity of pain according to VAS was 77.31 ± 16.66 before rTMS and 53.46 ± 22.49 after rTMS, which showed that pain intensity was significantly decreased after the intervention (p = 0.006).
Conclusions The use of rTMS of the primary motor cortex in patients who have undergone lumbosacral spine surgery and suffer from pain related to FBSS is associated with a significant reduction in the severity of pain. Because rTMS is a noninvasive treatment method, it can be used as a suitable treatment in these patients.
The Effect of Ascorbic Acid Supplementation on the Time of Healing of Rats Submitted to Neurosurgical Procedures
Authors: Rosa Tiago Gonçalves 
Published: December 2022

Abstract
Introduction Vitamin C is an essential nutrient for both humans and rats and has been noted for its beneficial properties, among them, healing.
Objective To verify the effect of oral and subcutaneous vitamin C supplementation on the healing time of surgical wounds of rats skulls.
Statistical Methodology Thirty male Wistar rats were divided into 3 groups: 10 from the control group (GI), 10 from the group treated with oral vitamin C (GII), and 10 from the group treated with subcutaneous vitamin C (GIII). Vitamin C was administered to GI and GIII animals from the 3rd to the 7th postoperative day, totaling 10 days of administration at a dose of 100 mg/kg/day. On the 4th day of the study, the rats were submitted to a surgical procedure consisting of a 2-cm incision of the skin of the animals' heads and suturing with single stitches. After a determined period, the rats were killed and submitted to the collection of material for study by the picrosirius red technique for the evaluation of collagen types I and III, the degree of hematoxylin and eosin healing, and the rate of contraction of the wound on subsequent days. The results were described in averages, medians, minimum and maximum values, and standard deviations. For the comparison of the three groups, the analysis of variance with one factor (one-way ANOVA) or Kruskal-Wallis non-parametric test was used. The normality of the variables was evaluated by the Shapiro-Wilk test. Values of p < 0.05 indicated statistical significance. The data were analyzed using the IBM SPSS Statistics for Windows, v.20.0. software. (IBM Corp., Armonk, NY, USA).
Results The amount of collagen type III was higher in the groups that received vitamin C, however, without significant difference (n = 0.292). In relation to the rate of contraction of the surgical wound, it was higher in the groups treated with vitamin C, with a significant difference between groups I and II (p = 0.001), and between groups I and III (p < 0.001). No significant difference was found between the groups that were treated with vitamin C (p = 0.227).
Conclusion Healing was more effective in the groups treated with vitamin C than in the group that did not receive vitamin supplementation. There was no significant difference in healing between the groups receiving oral or subcutaneous vitamin C.
Via clínica para cirugía mediante técnica WALANT fuera del estándar de cirugía mayor ambulatoria
Authors: Sanjuan-Cerveró Rafael , Peña-Molina Fernando , Sanjuan-Aragó Aurora , Iglesia Nicolas de la , Franco-Ferrando Nuria 
Published: December 2022

Resumen
Objetivo Desarrollar y valorar al año una vía clínica para procedimientos de cirugía de mano utilizando anestesia local sin torniquete y con el paciente despierto, denominada técnica WALANT (wide awake, local anesthesia, no tourniquet, en inglés).
Materiales y Métodos Se planificó y ejecutó una vía clínica para pacientes de cirugía de mano no compleja, y se realizó una comparativa de costes entre dotación completa del quirófano y cirugía local con la técnica WALANT.Como indicadores de la calidad, se calculó la tasa de suspensiones quirúrgicas y el número de pacientes intervenidos. Se comparó el tiempo medio de estancia hospitalaria entre los pacientes intervenidos de forma ordinaria y en el quirófano WALANT. Se valoró la reducción en la lista de espera quirúrgica en síndrome del túnel del carpo y dedo en gatillo.
Resultados Los gastos directos fueron un 48,9% menores en el procedimiento WALANT. Se valoraron 254 pacientes en 2020 y 339 en 2021. La tasa de suspensión fue del 5,1% (0,4% por motivos médicos). El tiempo de estancia en el hospital fue significativamente menor para los pacientes del grupo WALANT (z = -8,743; p = 0,000). La disminución en la lista quirúrgica fue de 113 días.
Conclusiones La cirugía mediante la técnica WALANT adecuada a esta vía clínica permite la intervención de pacientes con menos recursos, lo que disminuye los gastos directos y alivia las unidades de Cirugía Ambulatoria.
Awake Craniotomy for Cerebral Abscess with Pulmonary Arteriovenous Malformation
Authors: Shah Saloni K. , Shetty Anita , Mehta Dhairal 
Published: December 2022

AbstractA cerebral abscess can be a life-threatening complication of pulmonary arteriovenous malformations (PAVM), thus posing significant morbidity if left untreated. We report a case of an incidental finding of a PAVM in a patient diagnosed with cerebral abscess. A 22-year-old male presented to the emergency department with acute onset right-sided weakness in both upper and lower limbs for 1 week. Magnetic resonance imaging showed a ring-enhancing lesion within the left parasagittal frontoparietal region s/o intracerebral abscess. High-resolution computed tomography was done as a protocol in patients posted for surgery due to coronavirus disease 2019 and coincidentally, it showed a single well-defined parenchymal nodule, 4 × 3.4 cm in the lateral basal segment of the left lower lobe. The knowledge of the pathophysiology of PAVM and expected complications during general anesthesia (GA) and positive pressure mechanical ventilation is essential. In such conditions, awake craniotomy under conscious sedation and scalp block may be considered as an alternative to GA.
Lesiones traumáticas crónicas del complejo fibrocartílago triangular: ¿Cómo enfrentarlas?
Authors: Azócar Camila , Corvalán Gonzalo , Cobb Peter , Román Javier , Orellana Pablo 
Published: December 2022

ResumenLas lesiones crónicas del complejo fibrocartílago triangular (CFCT) son una entidad que no ha sido descrita previamente como tal y no existe consenso en su manejo. La temporalidad de la lesión y su potencial de reparación son aspectos fundamentales a la hora de indicar un tratamiento. Proponemos un esquema de enfrentamiento a lesiones traumáticas crónicas del CFCT y describimos una técnica novedosa de reconstrucción con injerto de brachioradialis con asistencia artroscópica. Mostramos los resultados y el seguimiento de dos pacientes intervenidos con esta técnica.
The Learning Curve in Skullbase Surgery Part 2–From the Microsurgical Lab Training to the Operative Room
Authors: Isolan Gustavo Rassier , Monteiro Jander , Vaz Marco Antônio Schlindwein , Lavinsky Joel , Araújo Ricardo Lopes de , Figueiredo Eberval Gadelha , Bark Samir Aler , Polanski José Fernando , Ribas Filho Carmem Austrália Paredes , Ribas Filho Jurandir Marcondes , Malafaia Osvaldo 
Published: December 2022

AbstractIn this second part, the authors review and suggest a methodology for studies in skull base surgery and training in microsurgical laboratory, based on their experiences and reflections. Not only are the foundations for the acquisition of microsurgical skills presented, but also what is needed to be an effective skullbase surgeon with good results. The present article reflects in particular the philosophy of professor Evandro de Oliveira and also serves to present to the neurosurgical community a new state-of-the-art laboratory for hands-on courses in Brazil, at the Faculdade Evangélica Mackenzie do Paraná.
COVID-Associated Sinonasal Mucormycosis: Radiological Pathological Correlation and Prognostic Value of MR Imaging
Authors: Agarwal Sheetal , Gautam Richa , Kumar Jyoti , Garg Anju , Khurana Nita , Meher Ravi , Wadhwa Vikram , Goel Ruchi , Arora Ritu 
Published: December 2022

Abstract
Purpose Our aim was to assess the sinonasal magnetic resonance imaging (MRI) features of acute invasive fungal rhinosinusitis (AIFRS) in coronavirus disease (COVID)-associated mucormycosis (CAM) and to correlate these with histopathology and patient outcome in terms of duration of hospital stay and survival at 10 weeks.
Methods Twenty patients with histopathologically confirmed sinonasal CAM underwent MRI (including postcontrast T1-weighted and diffusion-weighted imaging). Histopathological findings (presence of coagulative necrosis, granulomatous reaction, and fungal burden) were recorded and all patients were followed up at 6 and 10 weeks. Statistical analysis was done using chi-square test and Fischer's exact test.
Results Enhancement patterns seen in our subjects included homogeneous, heterogeneous, and lack of contrast enhancement (LOC), with LOC being the most common (65%). Diffusion restriction was found in 90% patients. Statistically significant correlation was found between LOC pattern and presence of coagulative necrosis (p-value = 0.007), extent of fungal hyphae (p-value = 0.047), and duration of hospital stay (p-value = 0.004). Restricted diffusion was also seen to correlate with a high fungal load (p-value = 0.007).
Conclusion Our study describes the MRI findings of AIFRS in CAM and highlights the imaging features which may be surrogate markers for coagulative necrosis and fungal burden.
Comparison of Nasal Analysis by Photographs (2D) against Low-cost Surface Laser Imaging (3D) and against Computed Axial Tomography Imaging
Authors: Rendón-Medina Marco Aurelio , Hanson-Viana Erik , Mendoza-Velez Maria de los Angeles , Hernandez-Ordoñez Rubén , Vazquez-Morales Hecly Lya , Pacheco-López Ricardo C. 
Published: December 2022

Abstract
Introduction In aesthetic surgery, we have a few evaluation tools that numerically and objectively measure the changes we make in patients. This article aimed to evaluate the nasal systematic analysis and compare findings between the three systems of nasal evaluation: photographs 2D, 3D surface imaging with the Kinect system, and 3D CT scan imaging.
Methods We designed a longitudinal and descriptive prospective study with simple non-blind randomization. To compare the systematic nasal analysis between the three methods. If the findings are similar, all three methods would be useful in independent clinical scenarios.
Results A total of 42 observations were included finding a minimum age of 21 with a mean of 28 years old. Also, 64% were female, 93% had adequate facial proportions, and 50% were Fitzpatrick III. For outcome statistics, we found differential nasal deviation between 3D images with a mean of 6.53 mm. While when comparing the nasal dorsum length, we found a statistical significance of p = 0.051. When comparing the nasal dorsum length index, we found no significant difference p = 0.32. Also, we did not find statistical significance when comparing the nasofrontal angle and tip rotation angle p = 1 for both.
Conclusion We found that the population we serve has characteristics of Hispanic mestizo nose. The three methods seem to evaluate systematic nasal analysis in a very similar way, and any of them can be used depending on the scenario and the needs of plastic surgeons.
On what there is in particular
Authors: Payton Jonathan D 
Published: December 2022

AbstractQuine says that ontology is about what there is, suggesting that to be ontologically committed to Fs is to be committed to accepting a sentence which existentially quantifies over Fs. Kit Fine argues that this gets the logical form of some ontological theses wrong. Fine is right that some ontological theses cannot be rendered simply as ‘There are Fs’. But the root of the problem has yet to be recognized, either by Fine or by his critics. Sometimes to adopt an ontological thesis is not merely to commit yourself to there being at least one F; it is to take a stand on which Fs there are. Once we recognize the ‘particularity’ of these ontological theses, we can adequately express them within the confines of a Quinean approach to ontology and ontological commitment.
Construction and development of a novel dual-gene coexpression system to promote heterologous protein secretion forStreptomyces
Authors: Yang Lingli , Hatanaka Tadashi 
Published: December 2022

ABSTRACTStreptomyces lividans is a potent host for the extracellular overproduction of heterologous proteins. To further improve the usability and productivity of S. lividans, a dual gene expression vector of “pTSKr duet” containing two strong constitutive promoters, scmpPc and kasOp*, was constructed. The success in the overproduction of two secretory enzymes simultaneously without interference with each other indicated that the “pTSKr duet” vector can realize the coexpression of two genes simultaneously and independently. Further, using the two-gene coexpression vector, we screened the effects of the overexpression of five factors that possibly promote secretion on the extracellular overproduction of heterologous secretory proteins. Interestingly, the coexpression of a quality control regulator (CssR) promoted the overproduction level to 1.3-fold for a stable heterologous protein of SMTG (transglutaminase from S. mobaraensis), while other four factors limited the overproduction of SMTG at different degrees.
Predicting miRNA-disease associations based on lncRNA–miRNA interactions and graph convolution networks
Authors: Wang Wengang , Chen Hailin 
Published: December 2022

AbstractIncreasing studies have proved that microRNAs (miRNAs) are critical biomarkers in the development of human complex diseases. Identifying disease-related miRNAs is beneficial to disease prevention, diagnosis and remedy. Based on the assumption that similar miRNAs tend to associate with similar diseases, various computational methods have been developed to predict novel miRNA-disease associations (MDAs). However, selecting proper features for similarity calculation is a challenging task because of data deficiencies in biomedical science. In this study, we propose a deep learning-based computational method named MAGCN to predict potential MDAs without using any similarity measurements. Our method predicts novel MDAs based on known lncRNA–miRNA interactions via graph convolution networks with multichannel attention mechanism and convolutional neural network combiner. Extensive experiments show that the average area under the receiver operating characteristic values obtained by our method under 2-fold, 5-fold and 10-fold cross-validations are 0.8994, 0.9032 and 0.9044, respectively. When compared with five state-of-the-art methods, MAGCN shows improvement in terms of prediction accuracy. In addition, we conduct case studies on three diseases to discover their related miRNAs, and find that all the top 50 predictions for all the three diseases have been supported by established databases. The comprehensive results demonstrate that our method is a reliable tool in detecting new disease-related miRNAs.