bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-term biological variation of plasma uracil in a Caucasian healthy population
Authors: Winther-Larsen Anne , Madsen Anne Tranberg , Nissen Peter H. , Hoffmann-Lücke Elke , Greibe Eva 
Published: March 2023

Abstract

Objectives
Plasma uracil is a new biomarker to assess the activity of dihydropyrimidine dehydrogenase before cancer treatment with fluoropyrimidine drugs. Knowledge on the biological variation of plasma uracil is important to assess the applicability of plasma uracil as a biomarker of drug tolerance and efficacy.

Methods
A total of 33 apparently healthy individuals were submitted to sequential blood draws for three days. On the second day, blood draws were performed every third hour for 12 h. Plasma uracil was quantified by LC-MS/MS. The within-subject (CVI) and between-subject (CVG) biological variation estimates were calculated using linear mixed-effects models.

Results
The overall median value of plasma uracil was 10.6 ng/mL (range 5.6–23.1 ng/mL). The CVI and CVG were 13.5 and 22.1%, respectively. Plasma uracil remained stable during the day, and there was no day-to-day variation observed. No differences in biological variation components were found between sex and no correlation to age was found. Four samples were calculated to be required to estimate the homeostatic set-point ±15% with 95% confidence.

Conclusions
Plasma uracil is subject to tight homeostatic regulation without semidiurnal and day-to-day variation, however between-subject variation exists. This emphasizes plasma uracil as a well-suited biomarker for evaluation of dihydropyrimidine dehydrogenase activity, but four samples are required to establish the homeostatic set-point in a patient.
LINC00858 facilitates formation of hepatic metastases from colorectal cancer via regulating the miR-132-3p/IGF2BP1 axis
Authors: Sun Peng , Luan Yusong , Cai Xuhao , Liu Qi , Ren Peide , Peng Panxin , Yu Yonggang , Song Bolun , Wang Yangyang , Chang Huijing , Ma Haoyue , Chen Yinggang 
Published: March 2023

Abstract
Hepatic metastasis is a major cause of colorectal cancer (CRC)-related deaths. Presently, the role of long non-coding RNAs (lncRNAs) in hepatic metastases from CRC is elusive. We dissected possible interplay between LINC00858/miR-132-3p/IGF2BP1 via bioinformatics approaches. Subsequently we analyzed mRNA expression of LINC00858, miR-132-3p and IGF2BP1 through qRT-PCR. Western blot was used to detect protein expression of IGF2BP1. RNA immunoprecipitation chip and dual-luciferase assay validated interaction between LINC00858 and miR-132-3p, as well as miR-132-3p and IGF2BP1. Cell viability, invasion, and migration were examined via CCK-8, colony formation, transwell and wound healing assays. Effect of LINC00858 on CRC hepatic metastases was validated via in vivo assay. Upregulated LINC00858 and IGF2BP1, and downregulated miR-132-3p were predicted in tumor tissues of patients with hepatic metastases from CRC. There were targeting relationships between LINC00858 and miR-132-3p, as well as miR-132-3p and IGF2BP1. Besides, LINC00858 facilitated progression of CRC cells. Rescue assay suggested that silencing LINC00858 suppressed CRC cell progression, while further silencing miR-132-3p or overexpressing IGF2BP1 reversed such effects. LINC00858 could facilitate CRC tumor growth and hepatic metastases. LINC00858 induced CRC hepatic metastases via regulating miR-132-3p/ IGF2BP1, and this study may deliver a new diagnostic marker for the disease.
Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer’s disease
Authors: Bagheri Seyyed Majid , Allahtavakoli Mohammad , Moradi Alireza 
Published: March 2023

Abstract
One of the current strategies in the treatment of Alzheimer’s disease is using drugs with acetylcholinesterase (AChE) inhibitory property. The existence of various compounds in plants as a potential source for finding new compounds to treat Alzheimer’s disease is a scientific fact. Many secondary metabolites and plant extracts have been reported with the ability to inhibit the AChE activity and improve memory and learning. These compounds can increase the concentration of acetylcholine in the brain and improve cholinergic function in individuals with Alzheimer’s disease and reduce the symptoms of this neurological disorder. Plants of Ferula genus are a good source of biologically active compounds such as sesquiterpene derivatives, coumarin derivatives and sulfur-containing compounds. Numerous studies on various extracts or purified compounds of Ferula genus have shown that members of this genus have the inhibitory properties on acetylcholinesterase and can also be effective in improving Alzheimer’s and amnesia. This review article summarizes studies on plants of Ferula extracts and their derived compounds to find AChE inhibitors.
Role of Jumonji domain-containing protein D3 and its inhibitor GSK-J4 in Hashimoto’s thyroiditis
Authors: Lu Xixuan , Liu Ying , Xu Li , Liang Haiyan , Zhou Xiaoli , Lei Hong , Sha Liping 
Published: March 2023

Abstract
Hashimoto’s thyroiditis (HT) is an autoimmune illness caused by a combination of genetic, epigenetic, and environmental factors. The pathogenesis of HT is not fully elucidated, especially in epigenetics. The epigenetic regulator Jumonji domain-containing protein D3 (JMJD3) has been extensively investigated in immunological disorders. This study has been performed to explore the roles and potential mechanisms of JMJD3 in HT. Thyroid samples from patients and healthy subjects were collected. We first analyzed the expression of JMJD3 and chemokines in the thyroid gland using real-time PCR and immunohistochemistry. In vitro, the apoptosis effect of the JMJD3-specific inhibitor GSK-J4 on the thyroid epithelial cell line Nthy-ori 3-1 was evaluated using FITC Annexin V Detection kit. Reverse transcription-polymerase chain reaction and Western blotting were applied to examine the inhibitory effect of GSK-J4 on the inflammation of thyrocytes. In the thyroid tissue of HT patients, JMJD3 messenger RNA and protein levels were substantially greater than in controls (P < 0.05). Chemokines C–X–C motif chemokine ligand 10 (CXCL10) and C–C motif chemokine ligand 2 (CCL2) were elevated in HT patients, and thyroid cells with stimulation of tumor necrosis factor α (TNF-α). GSK-J4 could suppress TNF-α-induced synthesis of chemokines CXCL10 and CCL2 and prohibit thyrocyte apoptosis. Our results shed light on the potential role of JMJD3 in HT and indicate that JMJD3 may become a novel therapeutic target in HT treatment and prevention.
Some standard and nonstandard finite difference schemes for a reaction–diffusion–chemotaxis model
Authors: de Waal Gysbert Nicolaas , Appadu Appanah Rao , Pretorius Christiaan Johannes 
Published: March 2023

Abstract
Two standard and two nonstandard finite difference schemes are constructed to solve a basic reaction–diffusion–chemotaxis model, for which no exact solution is known. The continuous model involves a system of nonlinear coupled partial differential equations subject to some specified initial and boundary conditions. It is not possible to obtain theoretically the stability region of the two standard finite difference schemes. Through running some numerical experiments, we deduce heuristically that these classical methods give reasonable solutions when the temporal step size

k

k

is chosen such that

k
≤
0.25

k\le 0.25

with the spatial step size

h

h

fixed at

h
=
1.0

h=1.0

(first novelty of this work). We observe that the standard finite difference schemes are not always positivity preserving, and this is why we consider nonstandard finite difference schemes. Two nonstandard methods abbreviated as NSFD1 and NSFD2 from Chapwanya et al. are considered. NSFD1 was not used by Chapwanya et al. to generate results for the basic reaction–diffusion–chemotaxis model. We find that NSFD1 preserves positivity of the continuous model if some criteria are satisfied, namely,

ϕ

(

k

)

[

ψ

(

h

)

]

2

=

1

2
γ

≤

1

2
σ
+
β

\frac{\phi \left(k)}{{\left[\psi \left(h)]}^{2}}=\frac{1}{2\gamma }\le \frac{1}{2\sigma +\beta }

and

β
≤
σ

\beta \le \sigma

, and this is the second novelty of this work. Chapwanya et al. modified NSFD1 to obtain NSFD2, which is positivity preserving if

R
=

ϕ

(

k

)

[

ψ

(

h

)

]

2

=

1

2
γ

R=\frac{\phi \left(k)}{{\left[\psi \left(h)]}^{2}}=\frac{1}{2\gamma }

and

2
σ
R
≤
1

2\sigma R\le 1

, that is

σ
≤
γ

\sigma \le \gamma

, and they presented some results. For the third highlight of this work, we show that NSFD2 is not always consistent and prove that consistency can be achieved if

β
→
0

\beta \to 0

and

k

h

2

→
0

\frac{k}{{h}^{2}}\to 0

. Fourthly, we show numerically that the rate of convergence in time of the four methods for case 2 is approximately one.
Exploring the Role of Teaching Aids in Enhancing Physical Education for Schoolchildren: A Literature Review
Authors: Vaskov Yurij 
Published: March 2023

Background and Study Aim. Physical education is an important aspect of school curriculum, and teaching aids play a crucial role in this process. The purpose of this study is to explore different approaches to defining teaching aids and their functions, as well as to identify sources for selecting them in the context of physical education for schoolchildren.
Methodology. The study is based on a review of relevant literature, including publications from the Vernadskyi National Library and Google search system. The search criteria used specific keywords related to the topic, and a total of 38 sources were selected for analysis.
Results. The study reveals the various approaches to defining teaching aids and their functions in physical education, as well as their sources of selection. A classification of teaching aids used in the process of physical education for schoolchildren is proposed, and the impact of these aids on the content and organization of physical education is highlighted.
Conclusions. The study concludes that there is no universally accepted definition of teaching aids, and the classification of these aids in the context of physical education for schoolchildren is yet to be established. Further research is needed to develop a comprehensive classification system that takes into account the various forms of physical education in schools. Ultimately, the findings of this study highlight the importance of teaching aids in the process of physical education and the need for a more systematic approach to their selection and use.
Defining the Structure of Physical Education Lessons in Secondary Schools: A Didactic Problem and Its Solutions
Authors: Vaskov Yurij 
Published: March 2023

Background and Study Aim. The organization of physical education lessons in secondary schools presents a didactic problem that requires choosing an optimal structure for the training session. This article aims to analyze the theoretical approaches of various scientists towards the typology of lessons, both in general didactic aspect and in relation to the educational subject of Physical Culture.
Methodology. The study employs a literature review using sources from the Vernadskyi National Library and Google search system, with 20 sources selected for analysis. The study focuses on the components of communicative competence and the assessment of its levels.
Results. Results showed that the concept of "lesson structure" has been defined with investigation on relevant stages, components, and elements included. The study proved that the types of lessons, age of students, and level of education influence the choice of structure. The study explored the theoretical issues of defining the concept "lesson structure," including the relevant stages, components, and elements. The article provides definitions of these concepts and highlights how different types of lessons, student age, and educational level influence the structure of a physical education lesson.
Conclusions. The study highlights the need for further attention towards determining the structure of physical culture lessons in general educational institutions by specialists in the field of theory and methods of physical education.
Kult i duchowość maryjna w plemionach grupy etnicznej Bantu Afryki Wschodniej
Authors: Klag Adam 
Published: March 2023

Celem niniejszego artykułu jest ukazanie duchowości i kultu maryjnego wśród chrześcijan, którzy należą do grupy etnicznej Bantu, zamieszkujących w większości rejony Afryki Wschodniej. Okazuje się, że wiele zwyczajów i tradycji biblijnego narodu wybranego, z którego pochodzili Jezus i Maryja, znajdują do dziś swoje odniesienia i podobieństwa wśród plemion afrykańskich. Warto tu wspomnieć tylko o takich wartościach, jak szacunek do życia, umiłowanie rodziny, ochrona dzieci i starszych, pamięć o dorobku i tradycji przodków czy solidarność międzyludzka, zwłaszcza w obliczu cierpienia. Owe ponadczasowe wartości tworzą w Afryce wspólnotę rodzinną i plemienną, a w duchowym rozumieniu wspólnotę wiary i Kościół Chrystusowy. Chrześcijaństwo zatem z całym bogactwem swoich wartości znalazło dobry grunt pod wzrost i ekspansję. Szacunek dla matki i przodków rodzinnych oraz plemiennych jest jedną z najważniejszych wartości, jakie pielęgnują mieszkańcy Afryki. Stąd wielki szacunek dla Maryi, Matki Jezusa, którą wierzący uważają również za swoją duchową Matkę. Afrykańczycy przyjęli Maryję jako swoją Matkę, która pociesza i daje nadzieję w cierpieniu oraz oręduje u swego Syna, Jezusa.
Music Therapy Assessment with the IMCAP-ND: A Pilot Study
Authors: Raposo Marisa M. , Abreu Ana Maria , Dionizio Leticia L. , Leite Teresa , Castro-Caldas Alexandre 
Published: March 2023

Background: Music therapy (MT) appears to be a valuable complementary intervention for children diagnosed with neurodevelopmental conditions, namely, autism spectrum disorders (ASD), who often present cognitive, academic, communicative, and social difficulties. Music therapy has been increasingly recommended as a standard support service for communication and social interaction in this specific neuropediatric setting. Objective: The aim of this pilot study was to determine the recruitment and protocol feasibility of music therapy for autistic children and explore trends towards the clinical utility of the IMCAP-ND[i] quantitative measure on assessing the focus on sound receptions, joint attention, turn-taking, auditory perception, sensory integration, social interaction, entrainment, and empathy, as a preparation for a future study wherein we will pursue with an MT intervention assessment. Furthermore, here we use the European Portuguese translated version of the IMCAP-NDPT scales to contribute to its validation and adaptation. Methods: Five autistic children received a weekly music therapy session of approximately 45 minutes for six months, totaling a minimum of 20 and maximum of 24 completed sessions per child. The IMCAP-NDPT and the Griffiths Mental Development Scales (GMDS) scales were applied pre- and post-test. Results: We tested the research design and the session’s protocol. All participants completed MT intervention and showed increase in social-emotional capacities, cognitive and perception skills, and overall responsiveness. However, our results indicate a need to review the inclusion criteria concerning participants with a single diagnosis (ASD), previous contacts with musical instruments, and the application of standardized music therapy settings. Conclusions: The design and protocol were perceived as acceptable and feasible, though some improvements were suggested for subsequent original research, and the IMCAP-NDPT version was considered usable. Our initial findings suggest the potential of music therapy for autistic children. Further intervention with efficacy assessment through a larger-scale randomized trial is needed, considering the content based on pilot findings.

[i] The Individual Music-Centered Assessment Profile for Neurodevelopmental Disorders (IMCAP-ND) is a criterion-referenced assessment of musical interaction, communication, cognition and perception, and responsiveness in musical-play for individuals with neurodevelopmental disorders at various developmental levels and chronological ages from children to adults. It is comprised by a set of three scales: Musical Emotional Assessment Rating Scale (MEARS), Musical Cognitive/Perception Scale (MCPS) and Musical Responsiveness Scale (MRS) (Carpente, 2013).
Optimalisasi Peran Akuntansi Manajemen dalam Bisnis
Authors: Rachman Yoga Tantular , Prayitno Yogo Heru 
Published: March 2023

Abstract. This research aims to find out how to optimize management accounting as a company strategy in achieving the goals expected by stakeholders. The research method used is descriptive method. Data from the results of direct observation through questionnaires and interviews are processed and described based on sources from the literature (articles, books, magazines, etc.). The results of the research show that good business management requires a variety of information that can help businesses optimize all of their potential. Relevant information related to the company's business activities is obtained by optimizing the role of management accounting in the company. One important role of Management Accounting is to provide information to the right people, in the right way at the right time to improve management's ability to understand the conditions around them, so as to be able to identify relevant activities appropriately, so that by itself will increase business productivity Keywords: Management Accounting, strategy; business Abstrak. Penelitian ini bertujuan untuk mengetahui bagaimana mengoptimalkan akuntansi manajemen sebagai strategi perusahaan dalam mencapai tujuan yang diharapkan oleh stakeholder. Metode penelitian yang digunakan peneliti adalah metode deskriptif. Data dari hasil observasi langsung melalui kuesioner dan wawancara diolah dan dideskriptifkan dengan berdasarkan sumber dari literatur (artikel, buku, majalah, dll). Hasil penelitian menunjukkan pengelolaan usaha yang baik membutuhkan berbagai informasi yang dapat membantu pelaku usaha mengoptimalkan seluruh potensi yang dimilikinya. Informasi-informasi relevan terkait dengan kegiatan usaha perusahaan diperoleh dengan mengoptimalkan peran akuntansi manajemen pada perusahaan. Salah satu peran penting dari Akuntansi Manajemen adalah untuk memberikan informasi kepada orang yang tepat, dengan cara yang benar pada waktu yang tepat untuk meningkatkan kemampuan manajemen dalam memahami keadaan di sekitarnya, sehingga mampu mengidentifikasi kegiatan yang relevan secara tepat, sehingga dengan sendirinya akan meningkatkan produktivitas usaha Kata kunci: Akuntansi Manajemen, strategi; bisnis
Corporate Social Responsibility Disclousure, Media Attention, Woman on Board, and Firm Value
Authors: Natalia Maria , Christy Yunita , Gunawan Yuliana 
Published: March 2023

Abstract. This study aims to examine the effect of corporate social responsibility disclosure on firm value with attention media and woman on board as a mediating variable. Disclosure of Corporate Social Responsibility in this study will be measured using performance indicators from the Global Reporting Initiative (GRI) 4.1. The research sample is a manufacturing company listed on the IDX during 2017. This study refers to the research of Li et al. (2017), who found that Corporate Social Responsibility is positively related to company value. Effective corporate social responsibility very important for the development of the company in the long run because it plays a role in increasing the value of the company. This study also refers to the study of Isa and Muhammad (2015), who found that the participation of woman on board can ensure full disclosure of the implementation of corporate social responsibility.Keywords. corporate social responsibility; corporate value; woman on board; media attention; global reporting initiativeAbstrak. Penelitian ini bertujuan untuk menguji pengaruh pengungkapan tanggung jawab sosial perusahaan terhadap nilai perusahaan dengan media attention dan woman on board sebagai variabel mediasi. Pengungkapan Corporate Social Responsibility dalam penelitian ini akan diukur menggunakan indikator kinerja dari Global Reporting Initiative (GRI) 4.1. Sampel penelitian ini adalah perusahaan manufaktur yang terdaftar di BEI selama tahun 2017. Penelitian ini mengacu kepada penelitian Li et al. (2017) yang menemukan menunjukkan bahwa Corporate Social Responsibility berhubungan positif dengan nilai perusahaan. Corporate Social Responsibility yang efektif sangat penting untuk pengembangan perusahaan dalam jangka panjang karena berperan dalam meningkatkan nilai perusahaan. Penelitian ini juga mengacu kepada penelitian Isa dan Muhammad (2015) yang menemukan bahwa partisipasi woman on board dapat memastikan pengungkapan penuh dari pelaksanaan tanggung jawab social perusahaan.Kata kunci. tanggung jawab sosial perusahaan; nilai perusahaan; woman on board; media attention; global reporting initiative
Analisis Faktor-Faktor yang Mempengaruhi Niat Ketidakpatuhan Wajib Pajak Daerah
Authors: Noermansyah Asrofi Langgeng , Aslamadin Ibnun 
Published: March 2023

Abstract. This study aims to determine the factors that influence the intention of non-compliance of taxpayers in paying local taxes in the city of Tegal. In this study using the object of restaurant taxpayers, hotel taxpayers and entertainment taxpayers registered at the Tegal City Regional Finance Agency so that the population in this study amounted to 447 taxpayers. The number of samples used using the Slovin formula is 82 taxpayers and the sampling method uses quota sampling. Research methods using qualitative methods and categorized into descriptive verification research that is causal. In research to test hypotheses using multiple linear regression analysis and the data used are primary data from questionnaire distribution. The results showed that the subjective norm variable influenced the intention of non-compliance of local taxpayers in Tegal City. While the attitude, control of moral behavior and obligation variables do not affect the intention of non-compliance of local taxpayers in Tegal City.Keywords. moral obligation; behavioral control; subjective norm; intention non-compliance; attitude Abstrak. Penelitian ini bertujuan untuk mengetahui faktor – faktor yang mempengaruhi niat ketidakpatuhan wajib pajak dalam membayar pajak daerah di Kota Tegal. Dalam penelitian ini menggunakan objek wajib pajak restoran, wajib pajak hotel dan wajib pajak hiburan yang terdaftar di Badan Keuangan Daerah Kota Tegal sehingga populasi dalam penelitian ini berjumlah 447 wajib pajak. Jumlah sampel yang digunakan menggunakan rumus slovin sejumlah 82 wajib pajak dan metode pengambilan sampel menggunakan quota sampling. Metode penelitian menggunakan metode kualitatif dan dikategorikan ke dalam penelitian deskriptif verifikatif yang bersifat kausal. Dalam penelitian untuk uji hipotesis menggunakan analisis regresi linier berganda dan data yang digunakan berupa data primer dari penyebaran kuisioner. Hasil penelitian menunjukkan bahwa variabel norma subjektif berpengaruh terhadap niat ketidakpatuhan wajib pajak daerah di Kota Tegal. Sedangkan variabel sikap, kontrol perilaku dan kewajiban moral tidak berpengaruh terhadap niat ketidakpatuhan wajib pajak daerah di Kota Tegal.Kata Kunci. kewajiban moral; kontrol perilaku; niat ketidakpatuhan; norma subjektif; sikap