bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methanolic extract of Kigelia africana and wound healing: an in vitro study
Authors: Karatay Kadriye Busra , Muftuler Fazilet Zumrut Biber , Law Benedict , Aras Omer 
Published: June 2023

Objective: Kigelia africana (Lam.) Benth. (Bignoniaceae) syn. Kigelia pinnata (Jacq. DC) is a tropical plant that is native to tropical Africa. The aim of this study was to determine if a methanolic extract prepared from Kigelia africana (KAE) can promote wound healing in treated human normal epidermal keratinocyte (HaCaT) cells and human normal foreskin fibroblast cell line (BJ) cells compared with untreated cells. Method: Experimental steps included: the methanolic extraction of the leaf and fruit of the Kigelia africana plant; the preparation of HaCaT and BJ cell lines; cell culture with a stable tetrazolium salt-based proliferation assay; and the evaluation of the wound healing effect of KAE (2μg/ml) in BJ and HaCaT cells. The phytochemical contents of KAE were determined using liquid chromatography quadrupole time-of-flight mass spectrometry. Results: The following molecules were identified as being present in the KAE, among others: cholesterol sulfate; lignoceric acid; embelin; isostearic acid; linoleic acid; dioctyl phthalate; arg-pro-thr; 15-methyl-15(S)-PGE1; sucrose; benzododecinium (Ajatin); and 9-Octadecenamide (oleamide). KAE effected faster wound healing in treated cells compared with untreated cells for both cell lines. HaCaT cells that had been mechanically injured and treated with KAE healed completely in 48 hours compared with 72 hours for untreated HaCaT cells. Treated BJ cells healed completely in 72 hours compared with 96 hours for untreated BJ cells. Concentrations of KAE up to 300μg/ml had a very low cytotoxic effect on treated BJ and HaCaT cells. Conclusion: The experimental data in this study support the potential of KAE-based wound healing treatment to accelerate wound healing.
Acute and sub acute toxicity of Amirdha Gandhi Kukkil Vallathy an effective Siddha herbo mineral formulation used in the treatment of rheumatoid arthritis in wistar albino rat model
Authors: Lawrence Juliet , Jabaris S Sugin Lal , Bhogireddy Ramadevi , Kadarkarai Kanakavalli , Natarajan Kabilan , Jhonson Christian Gnanaraj , Rathinam Ganesan , Sandhirappan Sivakkumar 
Published: June 2023

Abstract

Objectives

Amirdha Gandhi Kukkil Vallathy (AGKV) is a herbo mineral Siddha formulation which has Sulphur, Kukkil, Seendhil and Serankottai as major ingredients and it is indicated for 80 types of Vatham diseases. Uthiravatha suronitham is one among the vatham diseases and it’s clinical symptoms are correlated with Rheumatoid arthritis (RA). Since AGKV is a promising drug for RA, the safety of this drug has been validated by performing the acute and 28 days repeated oral dose toxicity study following the OECD guidelines 423 and 407.

Methods
The acute toxicity study has been performed by administering orally with a single dose of 300 and 2000 mg/kg body weight in rat models and the animals were observed for 14 consecutive days. Gross pathology was observed and animals were sacrificed at the end of the study. In 28 days repeated oral toxicity study, limit test has been carried out with a dose of 1,000 mg/kg body weight.

Results
No significant abnormality has been observed in the body weight, organ weight, biochemical parameters and histopathology studies. It has been revealed that this drug is safe upto 2000 mg/kg body weight in single dose study and 1,000 mg is a safer dose in the 28 days repeated oral toxicity study.

Conclusions
The results of acute and 28 days repeated oral toxicity studies revealed no adverse effects in animals and hence this drug AGKV is safe and can be administered in human.
The levels of cartonectin and procalcitonin in patients with chronic periodontitis and hypertension
Authors: Şahin Ata Özlem , Canakci Cenk Fatih , Özkan Karasu Yerda 
Published: June 2023

Abstract

Objectives
This study aimed to examine the effects of chronic periodontitis and essential hypertension on serum and salivary cartonectin (CTRP3) and procalcitonin (ProCT) levels.

Methods
Sixty non-smokers were seperated into four groups as; 15 people with essential hypertension (EH) and chronic periodontitis (CP) (HT+ CP+), 15 with EH (HT+ CP−), 15 with CP (HT− CP+), 15 control (HT− CP−). PPD, CAL, PI and GI were measured. All groups had their serum and saliva samples collected. Serum and saliva procalcitonin (ProCT) were measured using an electroluminescence method, and cartonectin (CTRP3) levels were determined by enzyme-linked immunosorbent assay.

Results
When compared to the control group, serum and saliva cartonectin (CTRP3) levels were considerably lower in all groups (respectively p<0.0001, p<0.0001). The serum cartonectin (CTRP3) levels were substantially higher in the HT− CP+ group than in the HT+ CP− group (p=0.002). Serum procalcitonin (ProCT) concentrations were found to be lowest in the HT− CP− group and highest in the HT+ CP+ group. Serum ProCT concentrations did not vary significantly across groups (p=0.110). Salivary procalcitonin (ProCT) levels were below the detection limit in all groups.

Conclusions
When periodontitis coexist with hypertension in individuals, they may have adversely affect each other due to the same sathways in the pathogenesis of these two disorders. So we can suggest that, serum and saliva cartonectin (CTRP3) may play a role during hypertension and periodontal inflammation and represent a novel future therapeutic target.
Determination of reference intervals of hemogram with advanced clinical parameters by indirect method on Sysmex XN-1000
Authors: Bildirici Mehmet Akif , Gülten Sedat , Çalışgan Neslihan Cihan 
Published: June 2023

Abstract

Objectives
The reference interval is the primary tool used to interpret laboratory test results. Each laboratory should determine reference intervals (RIs) that reflect their population. In this study, it was aimed to determine the RIs of hemogram routine and advanced clinical test parameters for our hospital and region by indirect method and to compare these calculated RIs with the limits recommended by the current manufacturer and the literature.

Methods
The hemogram results of patients aged 18–65 years who applied to Kastamonu Training and Research Hospital between July 2020 and June 2022, were included in the study. Hemogram analyzes were performed on Sysmex XN-1000 (Kobe, Japan) hematology auto analyzers. The RIs were determined by indirect method from the obtained data using the non-parametric percentage estimation method. Harris-Boyd method was used to decide on subgroup separation based on gender.

Results
All parameters had non-parametric distribution. RBC, HGB, HCT, MCH, MCHC, PLT, RDW-CV, RDW-SD, PCT, monocytes count, eosinophils count, monocytes % and macroR parameters which required gender-spesific RIs were determined separately for genders.

Conclusions
When the results are evaluated, it shows that the manufacturer’s recommendations together with the studies in the literature do not fully reflect the RIs of our population. Therefore, it is very important for each laboratory to determine its own RIs due to the differences in population, diet, technical equipment used and reference group. In addition, we think that our study will make a significant contribution to the literature, since there is insufficient data in the literature on RIs for advanced clinical parameters.
Investigation of SARS-CoV-2 in vaginal secretions of women with coronavirus disease 2019
Authors: Türkyilmaz Esengül , Özsoy Metin , Tanriverdi Merve Didem Eşkin , Dinç Bedia , Aydogan Sibel , Moraloğlu Tekin Özlem 
Published: June 2023

Abstract

Objectives
The present study investigates the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the vaginal swabs of female patients diagnosed with coronavirus disease 2019 (COVID-19) based on a positive real-time reverse transcription polymerase chain reaction (RT-PCR) test on a combined throat and nasopharyngeal swab.

Methods
This study included 48 female patients hospitalized in two tertiary hospitals diagnosed with COVID-19 based on a positive RT-PCR test of the combined throat and nasopharyngeal swab samples, along with clinical and radiological findings. The IBM SPSS software package was used for the statistical analysis of the study data.

Results
SARS-CoV-2 positivity was detected in only one patient (2.08 %) in the present study from RT-PCR tests of vaginal swab samples. This patient was a 64-year-old, postmenopausal woman who tested positive for SARS-CoV-2 in a RT-PCR test of a vaginal swab sample six days after having tested positive in an RT-PCR test of a combined throat and nasopharyngeal swab. The patient’s partner also tested positive for SARS-CoV-2 in an RT-PCR of a combined throat and nasopharyngeal swab.

Conclusions
The present study is the first to report the presence of SARS-CoV-2 in vaginal secretions in Türkiye. The authors believe there is a need for studies investigating the presence of SARS-CoV-2 in the semen samples of the male partners of female patients to establish whether the presence of SARS-CoV-2 in vaginal secretions can play a role in the transmission of the virus.
Blood in Stone and the Second Coming: On the Meaning of the Wenceslas Chapel in St. Vitus's Cathedral in Prague and the Karlstein Chapels
Authors: Uličný Petr 
Published: June 2023

Abstract
The essay attempts a new interpretation of the symbolic meaning of the chapel of St. Wenceslas in St. Vitus's Cathedral in Prague and the chapel of the Passion and Its Instruments, now St. Catherine's chapel, and the chapel of the Holy Cross, both at Karlstein Castle. They all feature a semiprecious stone dado, which was associated with the Passion of Christ due to its predominant red colour, while the upper part reflected the idea of the Heavenly Jerusalem and Christ's Second Coming. The chapels were either built to house the Passion relics or were probably planned for their storage, which in the case of the Wenceslas chapel perhaps influenced its unusual form, likely referring to Golgotha, the site of Christ's Passion.
Volumetric Dilatometer Study of Thermoreversible Aging Properties in Crumb Rubber–Modified Asphalt Binders
Authors: Liu Meifang , Xie Qingshan , Ding Haibo , Rahman Ali , Feng Xiongkai , Qiu Yanjun 
Published: June 2023

Abstract
The primary objective of this paper is to investigate the thermoreversible aging mechanism of crumb rubber–modified asphalt binders (CRMAs). In order to achieve this goal, an extended bending beam rheometer (Ex-BBR) test and volumetric dilatometer test were conducted. Additionally, isothermal crystallization kinetics (Avrami theory) and thermal stress calculation using the Hopkins and Hamming algorithm were employed to process the test data. The low-temperature properties of the asphalt specimens were characterized through calculations of creep stiffness (S), creep rate (m-value), grade loss (GL), thermal stress, and Avrami index (n). The experimental results indicate that thermoreversible aging is present in all asphalt samples during the long-term isothermal hardening process. This aging is characterized by continuous macroscopic volume shrinkage, accumulation of thermal stress, a crystallization process, and a process akin to crystallization (i.e., crumb rubber adsorbed oil at low temperatures). It was observed that CRMAs exhibit more severe thermoreversible aging and faster physical hardening rates due to their unique properties at a constant low temperature when compared with base asphalts. However, it was also observed that CRMAs can reduce the thermal stress by reducing the volumetric shrinkage coefficients and S. It is important to note that the volumetric shrinkage coefficients are not constant, which are related to the base asphalts, crumb rubber, and conditioning time. Therefore, it is not appropriate to use a single empirical constant to calculate thermal stress. Instead, multiple coefficients may need to be incorporated to account for the variability in shrinkage behavior.
Analysis of erosion susceptibility through urban scenarios for an expanding area
Authors: Pascoto Tamara Vieira , Furegatti Simone Andrea , Peixoto Anna Silvia Palcheco 
Published: June 2023

Urban scenarios can be used by decision makers on matters related to urban expansion, especially when urban areas have socio-environmental problems, such as those resulting from erosion processes. The aim is the analysis of erosion susceptibility with the construction of urban scenarios using the AHP method to assist decision making on urban expansion. Thus, the AHP (Analytical Hierarchical Process) technique was employed to analyze the data collected and a GIS for the spatialization and building of these scenarios. The methodology was developed based on a real case of a Brazilian city located in the state of São Paulo. To validate the methodology, the current scenario of the studied area was constructed and compared with the actual situation of the place. As a conclusion, the study was validated for the applied area and proved to be a tool capable of assisting local governments regarding decision-making processes for urban expansion.

Keywords: Urban Scenarios, AHP, Erosive Processes, Urban expansion, Erosion susceptibility
Potential savings of potable water due to the use of rainwater in a shopping mall in Recife/PE
Authors: Borges Ana Paula de Lima , Silva Simone Rosa da , Moura Micaella Raíssa Falcão de , Vasconcelos Ricardo Oliveira Bandeira de 
Published: June 2023

Water is one of the world's most valuable resources and indispensable for human survival. Given this, climate change and population growth generate an increase in demand for water resources, leading to water scarcity. The use of rainwater is a measure that mitigates environmental impacts, contributes to the retention of rainwater and reduces the demand for drinking water. Therefore, water scarcity stimulates the development of alternatives for water conservation. The objective of this study is to estimate the potential savings of potable water to be replaced by rainwater for non-potable use in a shopping center building in the Northeast of Brazil. The methodology consisted in simulating the volume of the reservoir for storage of collected rainwater. A study of the rainfall indexes and their periodicity was carried out, evaluating the months with highest and lowest precipitation. Subsequently, the Neptune computer program was used to determine the volume of the reservoir. To this end, a study was carried out with different catchment areas, in order to define the area that offers the best potential for supplying the water demands. The results indicated that the most suitable reservoir volume is 117 m³, with potential savings of 6.02% for drinking water and a complete and partial supply of 52.56% for rainwater demand. It was concluded that the potential for drinking water savings justifies the implementation of a rainwater harvesting system in a project of this size, proving to be technically feasible.
Bibliometric study on Ergonomics and Sustainability
Authors: Garcia Filho Joao Francisco Alfonso , Sugahara Cibele Roberta , Branchi Bruna Angela 
Published: June 2023

Reflections on ergonomics in the context of the sustainability of organizations are an important strategy for the improvement of safe working environments. In the literature, the discussion that encompasses the relationship between ergonomics and business sustainability is a topic little explored. The objective of the present research is to map and explore the scientific production in the field of ergonomics and sustainability in the period from 2010 to 2020, in order to show the temporal evolution of research and the existing articulation between the themes. The research method is exploratory. To carry out the research, the bibliometric technique was chosen. To this end, articles were searched in the SciELO and Scopus databases, and theses and dissertations in the Digital Library of Theses and Dissertations (BDTD) of CAPES on the theme of ergonomics and sustainability. The bibliometric research allows to identify limits, contributions and potentialities that highlight the need for the production of research and new knowledge that associate the theme of ergonomics with sustainability. The development of an ergonomics program associated with the principles of sustainability seems to be a way to manage occupational risks with preventive measures in occupational safety and health.
Equações de Chuvas Intensas para Auxílio das Obras de Drenagem Urbana no Estado do Pará
Authors: Rêgo Paulinne Maysi Mastop do , Mendes Izabela Mendonça da Silva , Aguiar Marcelo Figueiredo Massulo 
Published: June 2023

Os projetos e obras de drenagem urbana precisam de estudos de dados históricos de chuvas, tais como duração, intensidade e frequência. No entanto, para o Estado do Pará, há carência de pesquisas recentes que disponham de equações de chuvas intensas, visto que essas equações são modificadas à medida que novos dados são coletados e consistidos. Logo, o objetivo do presente trabalho é gerar as equações de chuvas intensas para 12 municípios paraenses, sendo um por região de integração do estado. Para isto, foram analisadas as séries históricas de precipitação, disponíveis no Portal HIDROWEB e, com o tratamento dos dados, aplicou-se a distribuição de probabilidades de Gumbel e a desagregação de chuvas (Método das Isozonas). Depois, adotou-se a linearização de Villela (1975), da qual foram retirados os coeficientes das equações de chuvas intensas, que foram validados pelo Coeficiente de Eficiência (COE). Os principais resultados foram: 12 equações de chuvas intensas com boa confiabilidade. Assim, calcularam-se as precipitações críticas para os dispositivos de drenagem e obtiveram-se as maiores precipitações em Paragominas, para dispositivos de drenagem superficial (228,37 mm/h) e de transposição de talvegues (192,80 mm/h), e em Cametá, para dispositivos de drenagem subsuperficial (54,01 mm/h). As menores precipitações calculadas foram em Belém, para obras de drenagem superficial (150,96 mm/h), e em Breves, para dispositivos de drenagem de transposição de talvegues (128,37 mm/h) e subsuperficial (35,11 mm/h). Concluiu-se que, as equações geradas são válidas para auxílio de projetos de sistemas de drenagem, atualizando as equações de chuvas existentes, para cada região de integração.
PALAVRAS-CHAVE: Equações de chuva. Estado do Pará. Drenagem Urbana.
Reflexão acerca das problemáticas socioambientais da população negra no Vale do Rio Carangola
Authors: Souza Márcia Aparecida de , Cunha Junior Henrique , Silva Meryelle Macedo da , Silva Rafael Ferreira da 
Published: June 2023

Este estudo pretendeu refletir sobre as problemáticas socioambientais urbanas nas áreas ocupadas pela população negra nas cidades de Carangola, Itaperuna e Natividade, que junto com outros municípios integram o vale do Rio Carangola. Nos fundamentamos metodologicamente na pesquisa afrodescendente, instrumentalizada pelo referencial teórico-metodológico dos percursos urbanos. Compreendemos a necessidade de ampliar os horizontes de conhecimento sobre a situação da população negra na sociedade brasileira destacando as especificidades regionais e apresentar motivos para inclusão das populações negras nos planejamentos regionais, atentando ainda para a necessidade de uma análise socioambiental na região do Vale do Carangola devido os danos decorrentes das catástrofes provocados pelas constantes inundações e desmoronamento das encostas.
PALAVRAS-CHAVE: Vale do rio Carangola. Problemáticas socioambientais. População negra.
Análise da eficiência do sistema de drenagem de Paulistânia-SP
Authors: Garcia Ana Júlia da Silva , Zaparolli Maria Luiza do Nascimento , Barros Ana Maria Taddei Cardoso de 
Published: June 2023

Este artigo tem como objetivo avaliar a eficiência do sistema de drenagem do município de Paulistânia/SP e propor intervenções sustentáveis e de infraestrutura. O município, localizado no interior de São Paulo, sofre com alguns problemas de escoamento superficial, tornando necessário uma investigação mais detalhada. A drenagem urbana tem grande importância na qualidade de vida e bem estar da população, em paralelo com cuidados com saúde, segurança e meio ambiente. Com intuito de explorar a performance do sistema, foi realizada uma análise por meio de um estudo de caso com abordagem quali-quantitativa, utilizando técnicas de dimensionamento convencionais e sua associação com ferramentas espaciais. Os resultados mostraram que o sistema de drenagem do município não é eficiente em sua totalidade, algumas áreas de contribuição necessitam de intervenção pois o sistema é ineficiente (não suportam toda a vazão necessária) ou inexistente. São apresentadas algumas soluções para aliviar o escoamento superficial por meio da implantação de novas tubulações de descarga com indicação do diâmetro necessário, assim como alternativas sustentáveis como posicionamento de novos dispositivos de captação e aplicação de áreas permeáveis.
PALAVRAS-CHAVE: Drenagem. Alagamentos. Desempenho.
Pengemasan Manisan Kolang-Kaling Basah (Arenga pinnata L.) dengan Bahan Kemas Plastik dan Botol Kaca pada Penyimpanan Suhu Ruang
Authors: Safriani Novi , Novita Melly , Sulaiman Ismail , Ratino Wenny 
Published: June 2023

Abstrak. Penelitian ini bertujuan untuk menentukan jenis kemasan terbaik yang dapat mempertahankan mutu manisan kolang-kaling (Arenga pinnata L.) basah selama penyimpanan pada suhu ruang. Pada penelitian ini telah dikaji pengaruh jenis kemasan (plastik polipropilen (PP), botol plastik polipropilen (PP), dan botol kaca) dan lama penyimpanan (0, 5, 10, dan 15 hari) terhadap mutu manisan kolang-kaling basah. Hasil penelitian menunjukkan bahwa manisan kolang-kaling basah dengan mutu terbaik berdasarkan uji organoleptik dan kimia diperoleh dari kombinasi perlakuan manisan kolang-kaling basah yang dikemas menggunakan botol kaca dan lama penyimpanan 5 hari pada suhu ruang dengan karakteristik sebagai berikut: kadar air 35,75%, kadar gula 50,56 mg/L, kadar total asam 0,16%, nilai pH 4,40, total mikroba 0,34 CFU/ml, nilai organoleptik warna 3,83; aroma 3,90; dan tekstur 3,87. Wet ‘Kolang-Kaling’ Sweets (Arenga pinnata L.) Packaging Using Plastic Material and Glass Jar in Room Temperature Storage Abstract. The aim of this study was to determine the best type of packaging to maintain the quality of wet “kolang-kaling”(Arenga pinnata L.) sweets during storage at the room temperature. The effects of the type of packaging (polypropylene plastic (PP), polypropylene plastic cup (PP),and glass jar (jam jar)), and storage duration (0, 5, 10, and 15 days) on the quality of the wet “kolang-kaling” sweets were investigated.The results showed that the best quality of the wet “kolang-kaling” sweets based on the organoleptic and chemical analysis obtained from the wet “kolang-kaling” sweets were packed by using glass jars, and storage of 5 days at room temperature with the following characteristics: water content of 35,75%, sugar content of 50,56 mg/L, total acid content of 0,16%, pH value of 4,40, the total microbial of 0,34 CFU/ml. The organoleptic value of the best treatment: color of 3,83; flavor of 3,90; texture of 3,87.