bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Responsiveness of Mental Health Service Professionals to Two Years of Pandemic Emergency in Italy
Authors: Magliano Lorenza , Di Maio Ginevra , Papa Chiara , Bonavigo Tommaso , Starace Fabrizio , Affuso Gaetana 
Published: July 2023

AbstractThis multicenter cross-sectional study explored the responsiveness of Mental Health Services (MHS) to two years of COVID-19 emergency in Italy. Specifically, the study explored the ability of staff to: acknowledge users’ capabilities and value teamwork; reinvent the service and maintain/introduce good practices; and, acknowledge the positive aspects of the pandemic experience. These aspects were investigated in relation to socio-demographic and professional variables. Professionals from 17 MHS of 15 Italian Regions completed an online questionnaire on the MHS transformation during COVID-19. Data were collected at the end of the national health emergency (March 1-April 30, 2022). Most of the 1077 participants said they: paid more attention to users’ physical health; revised treatment plans; mediated between user needs and safe work procedures; revalued the importance of gestures and habits; discovered unexpected personal resources in users; and, found positive aspects in the COVID-19 experience. The multivariate analyses showed significant differences in staff opinions related to gender, workplace, professional role, and geographic area of the MHS, covarying with staff work experience. Compared to male staff, female staff perceived MHS as more flexible and capable to maintain best practices, and female staff acknowledged more capabilities to the users. Compared to central and northern Italy staff, southern Italy staff gave more values to teamwork, perceived MHS as more capable to maintain best practices and acknowledged higher positive transformations. These findings may be useful for planning community-oriented MHS in the post-pandemic period, taking into account both the experience gained by staff and the MHS process of adaptation.
Statistical Behaviour and Modelling of Variances of Reaction Progress Variable and Temperature During Flame-Wall Interaction of Premixed Flames Within Turbulent Boundary Layers
Authors: Ghai Sanjeev Kr. , Ahmed Umair , Chakraborty Nilanjan 
Published: July 2023

AbstractThe statistical behaviour of the transport of reaction progress variable variance, $$\widetilde{{c^{^{\prime\prime}2} }},$$

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and non-dimensional temperature variance, $$\widetilde{{T^{^{\prime\prime}2} }},$$

T

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have been analysed using three-dimensional Direct Numerical Simulation (DNS) data of turbulent premixed flame-wall interaction with isothermal inert walls within turbulent boundary layers for (i) an unsteady head-on quenching of a statistically planar flame propagating across the boundary layer, and (ii) a statistically stationary oblique wall quenching of a V-flame. It has been found that the reaction rate contribution acts as a leading order source term to the transport of both reaction progress variable variance, $$\widetilde{{c^{^{\prime\prime}2} }},$$

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2

~

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and non-dimensional temperature variance, $$\widetilde{{T^{^{\prime\prime}2} }},$$

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2

~

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whereas the molecular dissipation term remains the leading order sink term for both configurations analysed here. With the progress of flame wall interaction, the magnitude of all the source terms for the transport equations of both reaction progress variable and non-dimensional temperature variances vanish in the near-wall region with the onset of flame quenching. However, the molecular dissipation term continues to act as a sink term. The performances of the existing models for turbulent scalar flux, reaction rate and scalar dissipation rate contributions have been assessed for both flame-wall interaction configurations based on a priori DNS analysis. The existing available models for scalar dissipation rate for temperature and the reaction rate contribution in the variance transport equations even with the previously proposed wall corrections do not adequately predict the behaviour in the near-wall region. Modifications have been suggested to the existing closure models for the scalar dissipation rate and the reaction rate contribution to the scalar variance transport equations to improve the predictions in the near-wall region. Furthermore, the recommended closures for the unclosed terms of both reaction progress variable variance, $$\widetilde{{c^{^{\prime\prime}2} }},$$

c

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2

~

,

and non-dimensional temperature variance, $$\widetilde{{T^{^{\prime\prime}2} }},$$

T

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2

~

,

are shown to accurately capture the corresponding variations obtained from DNS data for both near to and away from the wall.
Exact methods for the Oven Scheduling Problem
Authors: Lackner Marie-Louise , Mrkvicka Christoph , Musliu Nysret , Walkiewicz Daniel , Winter Felix 
Published: July 2023

AbstractThe Oven Scheduling Problem (OSP) is a new parallel batch scheduling problem that arises in the area of electronic component manufacturing. Jobs need to be scheduled to one of several ovens and may be processed simultaneously in one batch if they have compatible requirements. The scheduling of jobs must respect several constraints concerning eligibility and availability of ovens, release dates of jobs, setup times between batches as well as oven capacities. Running the ovens is highly energy-intensive and thus the main objective, besides finishing jobs on time, is to minimize the cumulative batch processing time across all ovens. This objective distinguishes the OSP from other batch processing problems which typically minimize objectives related to makespan, tardiness or lateness. We propose to solve this NP-hard scheduling problem using exact techniques and present two different modelling approaches, one based on batch positions and another on representative jobs for batches. These models are formulated as constraint programming (CP) and integer linear programming (ILP) models and implemented both in the solver-independent modeling language MiniZinc and using interval variables in CP Optimizer. An extensive experimental evaluation of our solution methods is performed on a diverse set of problem instances. We evaluate the performance of several state-of-the-art solvers on the different models and on three variants of the objective function that reflect different real-life scenarios. We show that our models can find feasible solutions for instances of realistic size, many of those being provably optimal or nearly optimal solutions.
Sustainability assessment of a conceptual multipurpose offshore platform in the South China Sea
Authors: Chen Shanyu , Duan Fengjun , Tabeta Shigeru 
Published: July 2023

AbstractAn offshore multipurpose floating platform (MPFP) combines different marine technologies to serve industry needs using one infrastructure; the aim of an MPFP is enlarging the synthesis benefits and reducing the negative impacts. Ocean thermal energy conversion (OTEC) in particular has attracted significant attention for its great potential and low environmental risk. This research demonstrates the system design of a conceptual MPFP in the South China Sea, evaluating its economic and environmental sustainability using an inclusive index. The system is based on a modular floating structure with a designed lifetime of 50 years. Tuna aquaculture, microalgae cultivation and processing, and the OTEC energy infrastructure are integrated to increase the profitability of the applications. We adopted a high-yield photobioreactor microalgae cultivation system and a low-cost barge-type floating structure combined with a semisubmergible to reduce the required area and cost of the floating structure and improve the sustainability of the system. The inclusive impact index “Triple-I-light (IIIlight)” was calculated to evaluate the environmental sustainability and economic feasibility of the floating system. The result shows that the new system becomes environmentally neutral (EF = BC) at a lifetime of 11.5 years, showing sustainability (IIIlight ≤ 0) at a lifetime of 20 years. The proposed system can produce fish with no external energy or feed supply. An autonomous system, such as the one proposed here, is considered very effective when it comes to utilizing the ocean and contributing to a sustainable society.
Challenges and developments in university research in Cambodia: a case study of two universities
Authors: Heng Kimkong 
Published: July 2023

AbstractIn recent years, university research in Cambodia has seen new developments and potential transformations although many challenges remain. Drawing on data from in-depth interviews with 22 Cambodian academics, this study shows that the development of university research in Cambodia is constrained by various challenges and barriers to research, preventing Cambodia from promoting higher education internationalization and transforming itself into a knowledge-based society. The study highlights key challenges that limit possibilities for further positive developments of higher education research and suggests the need for policy reforms to make a difference to the university research landscape in Cambodia. The study also points to the broader issues of North-South knowledge divide and calls for national and institutional initiatives to support Cambodian academics and empower them to enhance their research engagement. Finally, the study discusses implications for future research.
Galantamine mitigates testicular injury and disturbed spermatogenesis in adjuvant arthritic rats via modulating apoptosis, inflammatory signals, and IL-6/JAK/STAT3/SOCS3 signaling
Authors: Shafiey Sara I. , Ahmed Kawkab A. , Abo-Saif Ali A. , Abo-Youssef Amira M. , Mohamed Wafaa R. 
Published: July 2023

AbstractRheumatoid arthritis (RA) affects the joints and the endocrine system via persistent immune system activation. RA patients have a higher frequency of testicular dysfunction, impotence, and decreased libido. This investigation aimed to evaluate the efficacy of galantamine (GAL) on testicular injury secondary to RA. Rats were allocated into four groups: control, GAL (2 mg/kg/day, p.o), CFA (0.3 mg/kg, s.c), and CFA + GAL. Testicular injury indicators, such as testosterone level, sperm count, and gonadosomatic index, were evaluated. Inflammatory indicators, such as interleukin-6 (IL-6), p-Nuclear factor kappa B (NF-κB p65), and anti-inflammatory cytokine interleukin-10 (IL-10), were assessed. Cleaved caspase-3 expression was immunohistochemically investigated. Protein expressions of Janus kinase (JAK), signal transducers and activators of transcription (STAT3), and Suppressors of Cytokine Signaling 3 (SOCS3) were examined by Western blot analysis. Results show that serum testosterone, sperm count, and gonadosomatic index were increased significantly by GAL. Additionally, GAL significantly diminished testicular IL-6 while improved IL-10 expression relative to CFA group. Furthermore, GAL attenuated testicular histopathological abnormalities by CFA and downregulated cleaved caspase-3 and NF-κB p65 expressions. It also downregulated JAK/STAT3 cascade with SOCS3 upregulation. In conclusion, GAL has potential protective effects on testicular damage secondary to RA via counteracting testicular inflammation, apoptosis, and inhibiting IL-6/JAK/STAT3/SOCS3 signaling.
Graphical abstract
Simulation and dynamical analysis of a chaotic chameleon system designed for an electronic circuit
Authors: Abro Kashif Ali , Atangana Abdon 
Published: July 2023

AbstractThe moment when stability moves to instability and order moves to disorder constitutes a chaotic systems; such phenomena are characterized sensitively on the basis of initial conditions. In this manuscript, a fractal–fractionalized chaotic chameleon system is developed to portray random chaos and strange attractors. The mathematical modeling of the chaotic chameleon system is established through the Caputo–Fabrizio fractal–fractional differential operator versus the Atangana–Baleanu fractal–fractional differential operator. The fractal–fractional differential operators suggest random chaos and strange attractors with hidden oscillations and self-excitation. The limiting cases of fractal–fractional differential operators are invoked on the chaotic chameleon system, including variation of the fractal domain by fixing the fractional domain, variation of the fractional domain by fixing the fractal domain, and variation of the fractal domain as well as the fractional domain. Finally, a comparative analysis of chaotic chameleon systems based on singularity versus non-singularity and locality versus non-locality is depicted in terms of chaotic illustrations.
Coordination-free Multi-robot Path Planning for Congestion Reduction Using Topological Reasoning
Authors: Wang Xiaolong , Sahin Alp , Bhattacharya Subhrajit 
Published: July 2023

AbstractWe consider the problem of multi-robot path planning in a complex, cluttered environment with the aim of reducing overall congestion in the environment, while avoiding any inter-robot communication or coordination. Such limitations may exist due to lack of communication or due to privacy restrictions (for example, autonomous vehicles may not want to share their locations or intents with other vehicles or even to a central server). The key insight that allows us to solve this problem is to stochastically distribute the robots across different routes in the environment by assigning them paths in different topologically distinct classes, so as to lower congestion and the overall travel time for all robots in the environment. We outline the computation of topologically distinct paths in a spatio-temporal configuration space and propose methods for the stochastic assignment of paths to the robots. A fast replanning algorithm and a potential field based controller allow robots to avoid collision with nearby agents while following the assigned path. Our simulation and experiment results show a significant advantage over shortest path following under such a coordination-free setup.
Modeling and Trajectory Tracking Control for a Multi-Section Continuum Manipulator
Authors: Aner Elsayed Atif , Awad Mohammed Ibrahim , Shehata Omar M. 
Published: July 2023

AbstractThis paper presents a dynamic modeling and trajectory tracking control design for a hyper-redundant continuum manipulator (HRM), which is able to continuously bend along its length. The HRM has the advantages of high flexibility, large workspace, and low inertia, but also poses challenges of complex kinematics, and dynamic coupling. To address these challenges, the kinematics model was developed based on the piecewise constant curvature (PCC) assumption that captures the relationship between the cable lengths, joint angles, and end-effector pose. Inverse kinematics is presented geometrically by solving trigonometric equations. The dynamic model for the continuum robot (CR) is derived using the Euler–Lagrange representation, which incorporates the effects of gravity and elasticity. Accordingly, three control strategies are developed and applied to a two-section continuum robot, which are the inverse dynamic proportional integral derivative controller (PID), fuzzy logic controller (FLC), and sliding mode controller (SMC). We validate our proposed methods through simulations on various 3D trajectories, utilized MATLAB symbolic math toolbox in conjunction with Simulink simulation; demonstrate and evaluate different close-loop dynamic control responses for different scenarios. This simulation used in the creation of a unique animated simulation for a whole 3D continuum robot while tracking its desired trajectories. Finally, the simulation results demonstrate that our proposed methods can effectively control the HRM with high tracking performance, exhibiting enhanced responses in terms of settling time, rising time, and steady-state error. While the developed SMC outperforms Poth's PID and FLC in terms of robustness and settling time (51% and 10.3%), respectively.
Self-reported Deposits Versus Actual Deposits in Online Gambling: An Empirical Study
Authors: Auer Michael , Hopfgartner Niklas , Helic Denis , Griffiths Mark D. 
Published: July 2023

AbstractIn recent years a number of studies have used objective gambling data from online gambling operators to study gambling behavior. A few of these studies have compared gamblers’ actual gambling behavior (using account-based tracking data) with their subjective gambling behavior (using responses from survey data). The present study extended previous studies by comparing self-reported money deposited with the actual amount of money deposited. The authors were given access to an anonymized secondary dataset of 1,516 online gamblers from a European online gambling operator. After removing those who had not deposited any money in the previous 30 days, the final sample size for analysis was 639 online gamblers. The results indicated that gamblers were able to estimate fairly accurately how much money they had deposited in the past 30 days. However, the higher the amount of money deposited, the more likely gamblers underestimated the actual amount of money deposited. With respect to age and gender, there were no significant differences between male and female gamblers in their estimation biases. However, a significant age difference was found between those who overestimated and underestimated their deposits, with younger gamblers tending to overestimate their deposits. Providing feedback as to whether the gamblers overestimated or underestimated their deposits did not lead to any additional significant changes in the amount of money deposited when considering the overall reduction in deposits after self-assessment. The implications of the findings are discussed.
Scaling Up Latent Tuberculosis Infection Testing and Treatment for Non-US Born Patients in a Federally Qualified Community Health Center
Authors: Cochran J. , Tibbs A. , Haptu H. H. , Paradise R. K. , Bernardo J. , Tierney D. B. 
Published: July 2023

AbstractIn the United States (US), tuberculosis elimination strategies include scaling up latent tuberculosis infection (LTBI) diagnosis and treatment for persons at risk of progression to tuberculosis disease. The Massachusetts Department of Public Health partnered with Lynn Community Health Center to provide care to patients with LTBI who were born outside the US. The electronic health record was modified to facilitate collection of data elements for public health assessment of the LTBI care cascade. Among health center patients born outside the US, testing for tuberculosis infection increased by over 190%. From October 1, 2016 to March 21, 2019, 8827 patients were screened and 1368 (15.5%) were diagnosed with LTBI. Using the electronic health record, we documented treatment completion for 645/1368 (47.1%) patients. The greatest drop-offs occurred between testing for TB infection and clinical evaluation after a positive test (24.3%) and between the recommendation for LTBI treatment and completion of a treatment course (22.8%). Tuberculosis care delivery was embedded in the primary care medical home, bringing patient-centered care to those at high risk for loss to follow up. The partnership between public health and the community health center promoted quality improvement.
Biomedical and Nutritional Applications of Lactoferrin
Authors: Coccolini Carlotta , Berselli Elisa , Blanco-Llamero Cristina , Fathi Faezeh , Oliveira M. Beatriz P. P. , Krambeck Karolline , Souto Eliana B. 
Published: July 2023

AbstractLactoferrin (Lf) is a glycoprotein belonging to the transferrin family, which can be found in mammalian milk. It was first isolated from bovine milk in the 1930s, and later in the 1960s, it was determined from human milk. This multifunctional protein has the specific ability to bind iron. It plays various biological roles, such as antibacterial, antiviral, antifungal, anti-tumour, anti-obesity, antioxidant, anti-inflammatory and immunomodulatory activities. There are several studies describing its use against in various cancer cell lines (e.g., liver, lung and breast) and the glycoprotein has even been reported to inhibit the development of experimental metastases in mice. Previous studies also suggest Lf-mediated neuroprotection against age-related neurodegenerative diseases and it is also expected to attenuate aging. More recently, Lf has been proposed as a potential approach in COVID-19 prophylaxis. In this review, we discuss the recent developments about the biological activities of this pleiotropic glycoprotein that will reason the exploitation of its biomedical and supplementary nutritional value.
Why the debunking threat won’t go away
Authors: Kvandal Halvor 
Published: July 2023

AbstractA central claim often made to debunk religious beliefs is that they would be formed regardless of whether they are true or false. One way to support this claim is to apply findings from the cognitive science of religion. However, this use of science in an argument against religious beliefs has been strongly criticized. This article is about weaknesses in that criticism. I consider two arguments. Firstly, the critic of debunking can argue that the debunker makes empirically dubious claims about the origin of religious beliefs. I argue that the debunker can avoid this problem because the controversial empirical claims are not necessary. General naturalistic assumptions about the origin of religion also create worries that support the central debunking claim. The second criticism focuses on the highly general nature of the claims or assumptions debunkers make about the origin of religious beliefs. Critics maintain that such claims or assumptions, even if true, fail to affect the specific religious beliefs you or I form. I respond, arguing that this criticism fails to engage with the most prominent version of debunking, which aims at classes of beliefs. Furthermore, by making a detour through a related discussion in metaethics, I show how this version of the debunking argument can be extended in such a fashion that it applies to a given individual who forms a religious belief.
Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors
Authors: Vlachodimou Anna , Bouma Jara , De Cleyn Michel , Berthelot Didier , Pype Stefan , Bosmans Jean-Paul , van Vlijmen Herman , Wroblowski Berthold , Heitman Laura H. , IJzerman Adriaan P. 
Published: July 2023

AbstractEvaluation of kinetic parameters of drug-target binding, kon, koff, and residence time (RT), in addition to the traditional in vitro parameter of affinity is receiving increasing attention in the early stages of drug discovery. Target binding kinetics emerges as a meaningful concept for the evaluation of a ligand’s duration of action and more generally drug efficacy and safety. We report the biological evaluation of a novel series of spirobenzo-oxazinepiperidinone derivatives as inhibitors of the human equilibrative nucleoside transporter 1 (hENT1, SLC29A1). The compounds were evaluated in radioligand binding experiments, i.e., displacement, competition association, and washout assays, to evaluate their affinity and binding kinetic parameters. We also linked these pharmacological parameters to the compounds’ chemical characteristics, and learned that separate moieties of the molecules governed target affinity and binding kinetics. Among the 29 compounds tested, 28 stood out with high affinity and a long residence time of 87 min. These findings reveal the importance of supplementing affinity data with binding kinetics at transport proteins such as hENT1.