bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic Effect, Improved Cell Selectivity, and Elucidating the Action Mechanism of Antimicrobial Peptide YS12
Authors: Suchi Suzia Aktar , Lee Dae Young , Kim Young Kyun , Kang Seong Soo , Bilkis Tahmina , Yoo Jin Cheol 
Published: August 2023

Antimicrobial peptides (AMPs) have attracted considerable attention as potential substitutes for traditional antibiotics. In our previous research, a novel antimicrobial peptide YS12 derived from the Bacillus velezensis strain showed broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria. In this study, the fractional inhibitory concentration index (FICI) indicated that combining YS12 with commercial antibiotics produced a synergistic effect. Following these findings, the combination of YS12 with an antibiotic resulted in a faster killing effect against bacterial strains compared to the treatment with the peptide YS12 or antibiotic alone. The peptide YS12 maintained its antimicrobial activity under different physiological salts (Na+, Mg2+, and Fe3+). Most importantly, YS12 exhibited no cytotoxicity towards Raw 264.7 cells and showed low hemolytic activity, whereas positive control melittin indicated extremely high toxicity. In terms of mode of action, we found that peptide YS12 was able to bind with LPS through electrostatic interaction. The results from fluorescent measurement revealed that peptide YS12 damaged the integrity of the bacterial membrane. Confocal laser microscopy further confirmed that the localization of peptide YS12 was almost in the cytoplasm of the cells. Peptide YS12 also exhibited anti-inflammatory activity by reducing the release of LPS-induced pro-inflammatory mediators such as TNF-α, IL-1β, and NO. Collectively, these properties strongly suggest that the antimicrobial peptide YS12 may be a promising candidate for treating microbial infections and inflammation.
Mining Public Data to Investigate the Virome of Neglected Pollinators and Other Floral Visitors
Authors: de Santana Sabrina Ferreira , Santos Vinícius Castro , Lopes Ícaro Santos , Porto Joel Augusto Moura , Mora-Ocampo Irma Yuliana , Sodré George Andrade , Pirovani Carlos Priminho , Góes-Neto Aristóteles , Pacheco Luis Gustavo Carvalho , Fonseca Paula Luize Camargos , Costa Marco Antônio , Aguiar Eric Roberto Guimarães Rocha 
Published: August 2023

This study reports the virome investigation of pollinator species and other floral visitors associated with plants from the south of Bahia: Aphis aurantii, Atrichopogon sp., Dasyhelea sp., Forcipomyia taiwana, and Trigona ventralis hoozana. Studying viruses in insects associated with economically important crops is vital to understand transmission dynamics and manage viral diseases that pose as threats for global food security. Using literature mining and public RNA next-generation sequencing data deposited in the NCBI SRA database, we identified potential vectors associated with Malvaceae plant species and characterized the microbial communities resident in these insects. Bacteria and Eukarya dominated the metagenomic analyses of all taxon groups. We also found sequences showing similarity to elements from several viral families, including Bunyavirales, Chuviridae, Iflaviridae, Narnaviridae, Orthomyxoviridae, Rhabdoviridae, Totiviridae, and Xinmoviridae. Phylogenetic analyses indicated the existence of at least 16 new viruses distributed among A. aurantii (3), Atrichopogon sp. (4), Dasyhelea sp. (3), and F. taiwana (6). No novel viruses were found for T. ventralis hoozana. For F. taiwana, the available libraries also allowed us to suggest possible vertical transmission, while for A. aurantii we followed the infection profile along the insect development. Our results highlight the importance of studying the virome of insect species associated with crop pollination, as they may play a crucial role in the transmission of viruses to economically important plants, such as those of the genus Theobroma, or they will reduce the pollination process. This information may be valuable in developing strategies to mitigate the spread of viruses and protect the global industry.
Integrative Taxonomic Reappraisal and Evolutionary Biogeography of the Most Diverse Freshwater Mussel Clade from Southeast Asia (Pseudodontini)
Authors: Bolotov Ivan N. , Konopleva Ekaterina S. , Vikhrev Ilya V. , Gofarov Mikhail Y. , Kondakov Alexander V. , Lyubas Artem A. , Soboleva Alena A. , Chan Nyein , Lunn Zau , Win Than , Inkhavilay Khamla 
Published: August 2023

Freshwater mussels belonging to the tribe Pseudodontini (Bivalvia: Unionidae: Gonideinae) play a keystone role in riverine and lacustrine environments throughout Southeast Asia. Many of them are narrowly endemic and habitat specialists, which need special conservation efforts. Unfortunately, the systematics of this group is rather poorly understood. Here, we show that Pseudodon inoscularis, the type species of the genus Pseudodon, belongs to the eastern clade of the tribe (Southeast Asia, east of the Salween Basin), and, more certainly, clusters with members of the genus Monodontina. Hence, the latter genus becomes a synonym of Pseudodon, while the subtribe Pseudodontina (=Pilsbryoconchina syn. nov.) should be used as a name for the eastern clade. In turn, the genus Indopseudodon stat. rev. and the subtribe Indopseudodontina subtr. nov. must be applied as valid names for the western clade of the Pseudodontini (Ayeyarwady to Salween). We present a revision of the genus Indopseudodon with an updated synonymy and a description of a new species, I. indawgyiensis sp. nov. We also link four species-level genetic lineages from the Mekong to available taxonomic names in the genera Pseudodon and Sundadontina (Pseudodon cambodjensis, P. vagulus, Sundadontina harmandi, and S. sulcata). Based on morphological features, we revise the taxonomic position of several recent and fossil species that were traditionally placed in the Pseudodontini and transfer them to the genera Parvasolenaia, Pseudodontopsis, Ptychorhynchus, Simpsonasus nom. nov. (a new name for Nasus Simpson, 1900) (Gonideinae: Gonideini), Pseudobaphia (Unioninae: Unionini), Balwantia and Lamellidens (Parreysiinae: Lamellidentini).
Se llamaba Vasconcelos, de José Joaquin Blanco. Une biographie de la rédemption
Authors: Fell Claude 
Published: August 2023

« Se llamaba Vasconcelos, de José Joaquin Banco. Una biografia de la redención ».
En 1977, el periodista, ensayista y novelista José Joaquin Blanco publica Se llamaba Vasconcelos. Una evocación critica, primera biografia y a la vez ensayo critico dedicado a José Vasconcelos (1882-1959), protagonista clave de la vida politica y cultural de Mexico durante más de cincuenta anos. Esta biografia se estructura a partir de dos lineas de fuerza explicitadas por el autor : «una acción histórica» que reconstituye la trayectoria ideológica de Vasconcelos, que lo Ileva de una participación progresista a los asuntos pûblieos (esencialmente como Ministro de Educación y Cultura de 1921 a 1924) hasta una postura violentamente critica y ultra conservadora de la politica nacional ; «una concepción alegórica», donde Blanco estudia el quehacer identitario de Vasconcelos, privilegiando el análisis de su obra ensayistica y, sobre todo, de los primeras dos tomos de su autobiografia (Ulises criollo, 1935, La tormenta, 1936), que conocieron un inmenso éxito editorial en Mexico.
Preparation of Si nanoparticles from bamboo leaves and measurement of their photoluminescence and electroluminescence spectra
Authors: Banno Akira , Matsumoto Kimihisa , Kamiya Kazuhide , Ito So 
Published: August 2023

Abstract
In this study, Si nanoparticles were prepared by the Mg reduction of SiO2 extracted from bamboo leaves, and their optical properties were investigated. Si nanoparticles were filtered under reduced pressure to separate the residue and filtrate specimens. Although RT photoluminescence (PL) was observed for both Si nanoparticle specimens, the PL intensity of the filtrate specimens was approximately seven times higher than that of the residue specimens. An electroluminescence (EL) device was fabricated using the Si nanoparticles of the filtrate as the active layer, and its EL properties were evaluated. With an applied voltage of 15 V, red luminescence was observed in the active layer. The Si nanoparticles from the bamboo leaves had relatively broad EL spectra with a peak wavelength approximately 700 nm, similar to that of the PL spectra. These results indicated that Si nanoparticles from bamboo leaves can be recycled for light-emitting devices.
Comparison of mixed and unmixed Turbofan engine with intake air cooling: Parametric Study and Optimization-TOPSIS Decision
Authors: Sabzehali Mohamadreza , Alibeigi Mahdi 
Published: August 2023

<p>In this article, the effect of inlet air temperature on turbofan engine's performance and optimization of turbofan engine’s performance in take-off conditions with an inlet air cooling system is investigated. The objective functions are parameters that represent the performance of the turbofan engine, are as follows thrust force, Specific fuel consumption (SOx), thermal efficiency, nitrogen oxides emission index coefficient (SOx), and turbine inlet temperature. Overall compressor pressure ratio, fan pressure ratio, and bypass ratio are considered design variables. With inlet air temperature drop, thrust, TSFC, thermal efficiency, inlet air mass flow rate, fuel mass flow rate increase, and the SOx decreases. Values of the performance parameters of the turbofan engine vary based on the optimization with four objective functions and hydrogen fuel to choose the optimal modes, by defining the weight coefficient and using the TOPSIS algorithm that has been selected for two environmental and economic approaches. For both engines with both approaches and using the decision-making method, the highest score and low score for optimization state belong to the SNOx objective function and TSFC objective function, respectively. The thrust force of CFM56 3B2 and GENX 1B70 engines based on optimization with the SNOx has increased by about 19.1% and 12.6%compared to the design. </p>
A Joint Communication and Learning Framework for Hierarchical Split Federated Learning
Authors: Khan Latif U. , Guizani Mohsen , Al-Fuqaha Ala , Hong Choong Seon , Niyato Dusit , Han Zhu 
Published: August 2023

<p>In contrast to methods relying on a centralized training, emerging Internet of Things (IoT) applications can employ federated learning (FL) to train a variety of models for performance improvement and improved privacy preservation. FL calls for the distributed training of local models at end-devices, which uses a lot of processing power (i.e., CPU cycles/sec). Most end-devices have computing power limitations, such as IoT temperature sensors. One solution for this problem is split FL. However, split FL has its problems including a single point of failure, issues with fairness, and a poor convergence rate. We provide a novel framework, called hierarchical split FL (HSFL), to overcome these issues. On grouping, our HSFL framework is built. Partial models are constructed within each group at the devices, with the remaining work done at the edge servers. Each group then performs local aggregation at the edge following the computation of local models. End devices are given access to such an edge aggregated model so they can update their models. For each group, a unique edge aggregated HSFL model is produced by this procedure after a set number of rounds. Shared among edge servers, these edge aggregated HSFL models are then aggregated to produce a global model. Additionally, we propose an optimization problem that takes into account the RLA of devices, transmission latency, transmission energy, and edge servers' compute latency in order to reduce the cost of HSFL. The formulated problem is a mixed-integer non-linear programming (MINLP) problem and cannot be solved easily. To tackle this challenge, we perform decomposition of the formulated problem to yield sub-problems. These sub-problems are edge computing resource allocation problem and joint relative local accuracy (RLA) minimization, wireless resource allocation, task offloading, and transmit power allocation sub-problem. Due to the convex nature of edge computing, resource allocation is done so utilizing a convex optimizer, as opposed to a block successive upper-bound minimization (BSUM) based approach for joint relative local accuracy (RLA) minimization, resource allocation, job offloading, and transmit power allocation. Finally, we present the performance evaluation findings for the proposed HSFL scheme. </p>
Special issue on Innovative Technologies in Clinical Medicine & Dentistry (InTEchMed)
Authors: Trubiani Oriana 
Published: August 2023

The PhD course in Innovative Technologies in Clinical Medicine & Dentistry (InTEchMed) of the University “G. d’Annunzio” of Chieti-Pescara, is a newly instituted course that brings together professors and researchers belonging to scientific-disciplinary sectors that are homogeneous and coherent with a scientific project that has as its objective “ the pursuit of multidisciplinarity research” by finalizing the research, in terms of content and applicability, as a priority to satisfying the growing demands for a medicine of excellence with particular reference to spheres of interest of great relevance and considerable impact social responsibility attributable to the areas of specialization identified by the National Research Plan.
The PhD course in InTechMEd incorporates and processes technological and scientific innovations in the context of the skills that characterize it and, with a synergistic work, seeks to interface with the national and international scientific community with a constructive and innovative spirit. To this end, to promote the research activity of their PhD students, the First PhD InTechMEd Conference was organized, where the students presented the preliminary data of the research carried out and these oral presentations were collected to be published in the special issue of the Italian Journal of Anatomy and Embryology.
Measurement of TPO Ab and TG Ab levels and its association with thyroid dysfunction in Graves’ disease patients in Najaf city
Authors: Al-Jabery Qusay Abdulmuttaleb , Muzahem Hatem Rasha 
Published: August 2023

Graves’ disease (GD) is a common autoimmune disease that accounts for the majority of cases of hyperthyroidism in the developed world (Rich & Fleisher, 2018) Autoimmune thyroid Graves' disease is one of the most common autoimmune disease (AID), affecting 13 million people and targeting women seven times as often as men. It most often affects young to middle-aged adults but can occur at all ages.(Vos et al., 2009). Aim of The study is determination of TPO Ab levels and TG Ab and its correlation with thyroid dysfunction in Graves’ disease patients. A Case - control study was done on 100 patients with GD diagnosed at three hospitals in Najaf city in Iraq, in Al-Sadr Teaching Hospital, Al-Hakim General Hospital, and Al-Najaf Teaching Hospitals, respectively, with group of 32 healthy individual as control. Blood sample was collected from all patients and control. TPO Ab and TG Ab levels were measured by enzyme-linked immunosorbent assay (ELISA). While TSH, T3 and T4 hormones measured by Cobas e 411 analyzer. The result shown that female (89%) more than male (11%), and the mean age (36.86) were highest than other age. This result explain that there was a high significant in TSH, T3 and T4. Also there was a high significant in TPO Ab and TG Ab in patient compared with control group.
Problematika Problematika Guru dalam Implementasi Kurikulum Merdeka
Authors: Budi Teguh Harianto  
Published: August 2023

Penerapan kurikulum merdeka menjadi barang baru bagi dunia pendidikan. Penelitian ini berusaha untuk mendeskripsikan beragam probelamatika IKM dan solusinya. Data diperoleh dari responden perwakilan pengurus MGMP yang ada di Kabupaten Tanjung Jabung Barat,

melibputi, bidang studi Bahasa Indonesia, Matematika, Bahasa Inggris, Ilmu Pengetahuan Sosial dan Ilmu Pengetahuan Alam.. Bedasarkan pengolahan dan analisis data pada pembahasan yang dilakukan ternyata dapat disimpulkan; (1) problematika yang dihadapi guru di Kabupaten Tanjung Jabung Barat dalam implementasi kurikulum merdeka banyak dipanguruhi faktor dari luar dan dari dalam. (2) Sebagian besar guru kesulitan mengakses layanan PMM untuk mendapatkan pemahaman tentang Kurma karena terkendala jaringan telekomunikasi yang memadai serta jaringan listrik yang tidak handal. (3) Seringnya listrik padam dan jaringan telekomunikasi blank spot sangat mengganggu aktivitas guru. Sebagian guru terpaksa mencari waktu yang tepat dan mengunjungi pusat kecamatan untuk mendapatkan layanan jaringan telekomunikasi yang memadai. (4) Kendala dari dalam dipengaruhi oleh kemampuan guru dalam menggunakan perangkat android dan keterbatasan usia yang mendekati pensiun. (5) ditemukan juga guru yang tidakmelakukan diagnostik awal disebabkan karena tidak memiliki pemahaman yang cukup. Dibutukan workshop khusus tentang IKM dan penguatan kelembagaan komunitas guru sebagai tempat untuk mendapatkan beragam informasi tentang IKM. Workshop yang dilakukan dapat berupa bimbingan dan pendampingan khusus bagi guru secara berkala dan terukur agar diperoleh hasil pendampingan yang maksimal.
Kata kunci: Problematika, Implementasi Kurikulum Merdeka
Rapor Pendidikan Analisis Rapor Pendidikan Sebagai Dasar Penyusunan Program Berbasis Data
Authors: Budi Teguh Harianto  
Published: August 2023

Program Berbasis Data (PBD) adalah terobosan baru yang dilakukan pemerintah. Mengacu pada rapor pendidikan tentunya PBD menjadi alat baru yang sangat membantu satuan pendidikan menyelesaikan beragam persoalan yang dihadapi. Penelitian ini berusaha untuk mendeskripsikan pemahaman pemangku kebijakan dalam melakukan analisis rapor pendidikan untuk dasar PBD. Penelitian merupakan studi kasus di dua sekolah, SMPN 3 Kualatungkal dan SMPN Satap 7 Pengabuan, dua sekolah dengan karakteristik berbeda. Dari hasil penelitian, ditemukan bahwa kedua kepala sekolah sudah mampu memahami dan menganalisis rapor pendidikan sebagai acuan dasar PBD. Program yang dibuat merupakan rekomendasi dari analisis rapor pendidikan, terutama meningkatkan capaian kompetensi minimum pada indikator literasi dan numerasi. Kompetensi numerasi dengan keterangan kurang, artinya butuh peningkatan kemampuan pendidik untuk melaksanakan pembelajaran yang berbasis pada murid. Sedangkan indikator literasi di SMPN Satap 7 pada nilai kurang dengan persentase 11,76 persen, siswa yang mencapai kompetensi minimum. Sedangkan di SMPN 3 capaian kompetensinya nilai sedang yakni dengan nilai persentase 53,33 persen sudah mencapai kompetensi minimum. Platform merdeka mengajar (PMM) dan aktif di organisasi MGMP menjadi salah satu solusi untuk menyelesaikan permasalahan. Penambahan sarana penunjang pembelajaran seperti buku bacaan dan referensi juga menjadi program yang disusun sekolah. Sedangkan indikator karakter, kedua sekolah dengan predikat sedang.
Kata kunci: Analisis, Rapor Pendidikan, Berbasis Data
Hubungan antara Faktor-faktor Internal dan Eksternal dengan Kepatuhan Ibu dalam Program Imunisasi Dasar pada Bayi di Desa Bandengan Wilayah Kerja Puskesmas Dukuh Kota Pekalongan
Authors: Prajayanti Hilda , Setyowati Ana 
Published: August 2023

Imunisasi merupakan cara untuk meningkatkan kekebalan seseorang secara aktif terhadap suatu antigen. Upaya yang dilakukan untuk menurunkan angka kesakitan, kematian, kecacatan dari penyakit menular dan penyakit tidak menular termasuk penyakit yang dapat dicegah dengan imunisasi adalah dengan meningkatkan kesadaran bahwa kesehatan itu penting. Penelitian ini bertujuan untuk mengetahui adanya hubungan antara faktor-faktor internal dan eksternal dengan kepatuhan ibu dalam program imunisasi dasar pada bayi di Desa Bandengan Wilayah Kerja Puskesmas Dukuh Kota Pekalongan. Desain Penelitian menggunakan korelasional dengan pendekatan cross sectional. Jumlah sampel dalam penelitian ini sebanyak 35 responden dengan tehnik total sampling. Pengumpulan data dengan menggunakan kuesioner. Uji statistik menggunakan uji Kendall Tau. Hasil penelitian terhadap 35 responden menunjukkan bahwa sebagian besar ibu yaitu sebanyak 18 responden ( 51.4% ) patuh dan sebanyak 15 responden ( 42.9% ) tidak patuh dan sebanyak 2 responden (5,7 %) kurang patuh dalam pemberian imunisasi dasar pada bayi. Hasil pengujian menunjukkan bahwa pendidikan ibu berpengaruh terhadap kepatuhan ibu dalam program imunisasi yang ditunjukkan dengan nilai Kendall-Tau 0,025< 0,05. Sehingga dapat disimpulkan bahwa semakin tinggi pendidikan ibu maka semakin patuh dalam program imunisasi. Disarankan meningkatkan peran langsung dalam masyarakat melalui penelitian-penelitian yang lebih actual dan dibutuhkan berbagai pihak..
Measuring the 8621 A Diffuse Interstellar Band in Gaia DR3 RVS
Spectra: Obtaining a Clean Catalog by Marginalizing over Stellar
Types
Authors: Saydjari Andrew K. , M. Uzsoy Ana Sofía , Zucker Catherine , Peek J. E. G. , Finkbeiner Douglas P. 
Published: August 2023

Abstract
Diffuse interstellar bands (DIBs) are broad absorption features associated with
interstellar dust and can serve as chemical and kinematic tracers. Conventional
measurements of DIBs in stellar spectra are complicated by residuals between
observations and best-fit stellar models. To overcome this, we simultaneously
model the spectrum as a combination of stellar, dust, and residual components,
with full posteriors on the joint distribution of the components. This
decomposition is obtained by modeling each component as a draw from a
high-dimensional Gaussian distribution in the data space (the observed
spectrum)—a method we call “Marginalized Analytic Data-space Gaussian Inference
for Component Separation” (MADGICS). We use a data-driven prior for the stellar
component, which avoids missing stellar features not well modeled by synthetic
spectra. This technique provides statistically rigorous uncertainties and
detection thresholds, which are required to work in the low signal-to-noise
regime that is commonplace for dusty lines of sight. We reprocess all public
Gaia DR3 RVS spectra and present an improved 8621 Å DIB catalog, free of
detectable stellar line contamination. We constrain the rest-frame wavelength to
8623.14 ± 0.087 Å (vacuum), find no significant evidence for DIBs in the Local
Bubble from the 1/6th of RVS spectra that are public, and show unprecedented
correlation with kinematic substructure in Galactic CO maps. We validate the
catalog, its reported uncertainties, and biases using synthetic injection tests.
We believe MADGICS provides a viable path forward for large-scale spectral line
measurements in the presence of complex spectral contamination.
Triple synchronous malignancies of the stomach, bladder and thyroid in a previously treated prostate cancer patient: A Case Report
Authors: Oey Oliver , Tiong Siaw Sze , Wong Sze Ling , Navadgi Suresh , Khan Yasir 
Published: August 2023

Cancers that develop within six months of the first primary cancer are referred to as synchronous malignancies. These malignancies are difficult to diagnose and treat, with treatment primarily based on case reports.
We report here the case of a 51-year-old male with prior history of prostate cancer who presented with haematuria to the general practice. A CT pyelogram showed left bladder wall lesion that was further investigated with cystoscopy and biopsy confirmed as muscle-invasive urothelial carcinoma. Incidentally, two perigastric nodes and hepatic lesions were noted on CT. FDG-PET revealed high-grade uptake in the right lobe of thyroid gland and cervical nodes that was biopsy proven as papillary thyroid carcinoma. Subsequently, gastroscopy and a biopsy of the gastric lesion confirmed a gastric neuroendocrine tumour. The patient underwent chemoradiotherapy, total thyroidectomy, and commenced somatostatin analogue for treatment of urothelial carcinoma, papillary thyroid carcinoma, and neuroendocrine tumour, respectively.
The diagnosis and treatment of synchronous malignancies is complex. A multidisciplinary team approach is required to improve treatment outcomes.