bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metastatic infiltration of nervous tissue and periosteal nerve sprouting in multiple myeloma induced bone pain
Authors: Diaz-delCastillo Marta , Palasca Oana , Nemler Tim T. , Thygesen Didde M , Chávez-Saldaña Norma A , Vázquez-Mora Juan A , Ponce Gomez Lizeth Y , Jensen Lars Juhl , Evans Holly , Andrews Rebecca E. , Mandal Aritri , Neves David , Mehlen Patrick , Caruso James P , Dougherty Patrick M. , Price Theodore J , Chantry Andrew , Lawson Michelle A , Andersen Thomas L. , Jimenez-Andrade Juan M , Heegaard Anne-Marie 
Published: December 2022

AbstractMultiple myeloma (MM) is a neoplasia of B plasma cells that often induces bone pain. However, the mechanisms underlying myeloma-induced bone pain (MIBP) are mostly unknown. Using a syngeneic MM mouse model, we show that periosteal nerve sprouting of calcitonin-gene related protein (CGRP+) and growth associated protein 43 (GAP43+) fibres occurs concurrent to the onset of nociception and its blockade provides transient pain relief. MM patient samples also showed increased periosteal innervation. Mechanistically, we investigated MM induced gene expression changes in the dorsal root ganglia (DRG) innervating the MM-bearing bone and found alterations in pathways associated with cell cycle, immune response and neuronal signalling. The MM transcriptional signature was consistent with metastatic MM infiltration to the DRG, a never-before described feature of the disease that we further demonstrated histologically. In the DRG, MM cells caused loss of vascularization and neuronal injury, which may contribute to late-stage MIBP. Interestingly, the transcriptional signature of a MM patient was consistent with MM cell infiltration to the DRG. Overall, our results suggest that MM induces a plethora of peripheral nervous system alterations that may contribute to the failure of current analgesics and suggest neuroprotective drugs as appropriate strategies to treat early onset MIBP.Significance statementMultiple myeloma is a painful bone marrow cancer that significantly impairs the quality of life of the patients. Analgesic therapies for myeloma-induced bone pain (MIBP) are limited and often ineffective, and the mechanisms of MIBP remain unknown. In this manuscript, we describe cancer-induced periosteal nerve sprouting in a mouse model of MIBP, where we also encounter metastasis to the dorsal root ganglia (DRG), a never-before described feature of the disease. Concomitant to myeloma infiltration, the lumbar DRGs presented blood vessel damage and transcriptional alterations, which may mediate MIBP. Explorative studies on human tissue support our preclinical findings. Understanding the mechanisms of MIBP is crucial to develop targeted analgesic with better efficacy and fewer side effects for this patient population.
INDIVIDUAL LIGHT HISTORY MATTERS TO COPE WITH THE ANTARCTIC SUMMER
Authors: Castillo Julieta , Tonon André Comiran , Hidalgo María Paz Loayza , Silva Ana , Tassino Bettina 
Published: December 2022

ABSTRACTThe effect of light, main zeitgeber of the circadian system, depends on the time of day it is received. A brief trip to the Antarctic summer (ANT) allowed us to explore the impact of a sudden and synchronized increase in light exposure on activity-rest rhythms and sleep patterns of 11 Uruguayan university students, and to assess the significance of light history in determining individual circadian phase shift. Measurements collected in the peri-equinox in Montevideo, Uruguay (baseline situation, MVD) and in ANT, included sleep logs, actigraphy, and salivary melatonin to determine dim-light melatonin onset (DLMO), the most reliable marker of circadian phase. The increase in light exposure in ANT with respect to MVD (affecting both light-sensitive windows with opposite effects on the circadian phase) resulted in no net change in DLMO among participants as some participants advanced their DLMO and some others delayed it. The ultimate cause of each participant’s distinctive circadian phase shift relied on the unique change in light exposure each individual was subjected to between their MVD and ANT. This is the first study to show a clear physiological effect of light either advancing or delaying the circadian phase dependent on individual light history in an ecological study.
Pioneer transcription factors coordinate active and repressive gene expression states to regulate cell fate
Authors: Matsui Satoshi , Granitto Marissa , Buckley Morgan , Shiley Joseph , Zacharias William , Mayhew Christopher , Lim Hee-Woong , Iwafuchi Makiko 
Published: December 2022

AbstractPioneer transcription factors (TFs) regulate cell fate by establishing transcriptionally primed and active states. However, cell fate control requires the coordination of both lineage-specific gene activation and repression of alternative lineage programs, a process that is poorly understood. Here, we demonstrate that the pioneer TF Forkhead box A (FOXA), required for endoderm lineage commitment, coordinates with the PR domain zinc finger 1 (PRDM1) TF to recruit Polycomb repressive complexes, which establish bivalent enhancers and repress alternative lineage programs. Similarly, the pioneer TF OCT4 coordinates with PRDM14 to repress cell differentiation programs in pluripotent stem cells, suggesting this is a common feature of pioneer TFs. We propose that pioneer and PRDM TFs coordinate recruitment of Polycomb complexes to safeguard cell fate.One-Sentence SummaryPioneer and PRDM transcription factors repress alternative lineage programs.
Decoding Numeracy and Literacy in the Human Brain: Insights from MEG and MVPA
Authors: Nara Sanjeev , Raza Haider , Carreiras Manuel , Molinaro Nicola 
Published: December 2022

AbstractNumbers and letters are the fundamental building blocks of our everyday social interactions. Previous studies have focused on determining the cortical networks shaped by numeracy and literacy in the human brain, partially supporting the hypothesis of distinct neural circuits involved the processing of the two categories. In this study, we aim to investigate the temporal dynamics for number and letter processing. We present MEG data from two experiments (N=20 each). In the first experiment, single numbers, letter, and their respective false fonts (false numbers and false letters) were presented, whereas, in the second experiment, numbers, letters, and their respective false fonts were presented as a string of characters. We used multivariate pattern analysis techniques (time-resolved decoding and temporal generalization) testing the strong hypothesis that the neural mechanisms supporting letter and number processing can be logistically classified as categorically separate. Our results show a very early dissociation (∼100 ms) between numbers, and letters when compared to false fonts. Number processing can be dissociated with similar accuracy when presented as isolated items or strings of characters, while letter processing shows dissociable classification accuracy for single items compared to strings. These findings reinforce the evidence indicating that early visual processing can be differently shaped by the experience with numbers and letters; this dissociation is stronger for strings compared to single items, thus showing that combinatorial mechanisms for numbers and letters could be categorically distinguished and influence early brain activity.
A change in behavioral state switches the pattern of motor output that underlies rhythmic head and orofacial movements
Authors: Liao Song-Mao , Kleinfeld David 
Published: December 2022

SUMMARYThe breathing rhythm serves as a reference that paces orofacial motor actions and orchestrates active sensing. Past work reports that pacing occurs solely at a fixed phase relative to sniffing. We reëvaluated this constraint as a function of exploratory behavior. Allocentric and egocentric rotations of the head and the electromyogenic activity of the underlying motoneurons for head and orofacial movements were recorded in free-ranging rats as they searched for food. We found that a change in state from foraging to rearing is accompanied by a change in the phase of muscular activation relative to sniffing, so that pacing now occurs at one of two phases. Further, head-turning is biased such that an animal gathers a novel sample of its environment upon inhalation. In toto, the coordination of active sensing has a previously unrealized computational complexity that, in principle, can emerge from hindbrain circuits with fixed architecture and credible synaptic time-delays.
Architectural design research in small practices
Authors: Aydemir Ayşe Zeynep , Jacoby Sam 
Published: December 2022

PurposeThere has been a recently growing interest by architects in practice-based research and the impact of research. At the same time, several post-graduate architecture programmes with practice-led research agendas were founded. This shift towards architectural design research is analysed using the notions of “process-driven research”, “output-driven research” and “impact”. The study aims to investigate and unveil the link between graduate programmes and graduates with a research interest and to test the tripartite model of “process-driven research”, “output-driven research” and “impact” in the context of small architectural practices.Design/methodology/approachThe study uses a qualitative and exploratory research approach that includes 11 in-depth interviews conducted in 2020, during the first nationwide COVID-19 lockdown in the United Kingdom (UK) selected interviews were architects representing (1) members or alumni of practice-related graduate architecture programmes in London and (2) founders of London-based small architectural practices within the last decade.FindingsWhile focussing on the London context, the paper offers transferable insights for the key potentials of practice-led design research in small architectural practices and the actions that might improve research practice.Originality/valueThis paper addresses a lack of studies on how design research differs between diverse types and sizes of architectural firms, why emerging small architectural practices increasingly engage with research and how this shapes their practice. This knowledge is important to fully understanding architectural design research and its strengths or weaknesses.
Examining key macroeconomic determinants of serviced apartments price index: the case of Kuala Lumpur, Malaysia
Authors: Cheng Chin Tiong , Teck Ling Gabriel Hoh 
Published: December 2022

Purpose
Increasing overhang of serviced apartments poses a serious concern to the national property market. This study aims to examine the impacts of macroeconomic determinants, namely, gross domestic product (GDP), consumer confidence index (CF), existing stocks (ES), incoming supply (IS) and completed project (CP) on serviced apartment price changes.

Design/methodology/approach
To achieve more accurate, quality price changes, a serviced apartment price index (SAPI) was constructed through a self-developed hedonic price index model. This study has collected 1,567 transaction data in Kuala Lumpur, covering 2009Q1–2018Q4 for price index construction and data were analysed using the vector autoregressive model, the vector error correction model and the fully modified ordinary least squares (OLS) (FMOLS).

Findings
Results of the regression model show that only GDP, ES and IS were significantly associated with SAPI, with an R2 of 0.7, where both ES and IS have inverse relationships with SAPI. More precisely, it is predicted that the price of serviced apartments will be reduced by 0.56% and 0.21% for every 1% increase in ES and IS, respectively.

Practical implications
Therefore, government monitoring of serviced apartments’ future supply is crucial by enforcing land use-planning regulations via stricter development approval of serviced apartments to safeguard and achieve more stable property prices.

Originality/value
By adopting an innovative approach to estimating the response of price change to supply and demand in a situation where there is no price indicator for serviced apartments, the study addresses the knowledge gap, especially in terms of understanding what are the key determinants of, and to what extent they influence, the SAPI.
The relationship between differentiated instruction and learner levels of engagement at university
Authors: Moallemi Robyn 
Published: December 2022

PurposeThe aim of this paper is to explore the importance of individual learner differences and the effect differentiated instruction (DI) has on learners' levels of engagement.Design/methodology/approachThe author carried out this research using a small-scale action research (AR) study.FindingsThe findings suggest that in acknowledging and responding to individual learner differences, especially interests, levels of learner engagement are positively affected.Research limitations/implicationsThis study’s key limitations were sample size, short-term study and potential teacher as researcher bias.Practical implicationsRecommendations were made for a further longitudinal study into the relationship between DI and language learner levels of engagement at University. An additional study into DI that looksbeyond language learning at HE, could add value to pedagogic approaches, which could make courses of greater intrinsic value to its students.Originality/valueThis research study aims to help fill a gap in the literature on the application of DI, as well as a unique perspective into its effect on learner engagement within a university context.
Size, conditional idiosyncratic risk and price momentum: an international study
Authors: Fan Steve , Yu Linda , Beyer Deborah , Beyer Scott 
Published: December 2022

PurposeThis paper jointly examines how firm size and idiosyncratic risk impact momentum returns.Design/methodology/approachUsing regression analysis, the authors investigate how firm size and idiosyncratic risk impact price momentum. The authors review firm price data in 25 country markets in the Thomson Financial Datastream database from 1979 to 2009.FindingsThis study’s findings suggest price momentum is more significant among stocks with smaller size and higher idiosyncratic risk. The authors find that winner and loser portfolios have significantly smaller size and higher idiosyncratic risk than portfolios in the middle quintiles.Research limitations/implicationsThis study’s results are consistent with the notion that firm size matters in price momentum and mispricing is greatest for small firms because of the greater risk potential to arbitrageurs. In addition, this finding that firms with higher idiosyncratic risk have greater price momentum supports the idea that investors underreact to firm-specific information.Practical implicationsThis work finds evidence that investors underreact to firm-specific information. As such, these findings are of particular interest for investors looking to exploit opportunities for abnormal returns through price momentum trading.Originality/valueThis paper jointly examines the effects of firm size and idiosyncratic risk on momentum returns. This investigation considers these effects in the global markets. This work adds to the research base by illustrating that both winner and loser portfolios have significantly smaller size and higher idiosyncratic risk than portfolios in the middle quintiles. Also unique to this study, the authors capture the time-variation of expected IdioRisk and the asymmetric effects of volatility by using an exponential general autoregressive conditional heteroskedastic (EGARCH) model to calculate conditional idiosyncratic risk.
Web search to access health information by adults with intellectual disability
Authors: Kuruppu Arachchi Theja , Sitbon Laurianne , Zhang Jinglan , Koplick Stewart , Hoogstrate Maria , Brereton Margot 
Published: December 2022

PurposeThis study explored the current and desired use of web-search, particularly for health information, by adults with intellectual disability.Design/methodology/approachThe authors surveyed 39 participants who were in supported employment or attending day centers in Australia. The survey, delivered through structured interviews, increased participation with data in a form of the participants' narratives. The responses were analyzed through a form of thematic analysis.FindingsThis study's results present the participants' daily health information interests, approaches to finding information and expectations for self-sufficiency. Participants' interest was in information to stay healthy rather than purely clinical information. The participants were keen to use online information in, accessible as well as entertaining and engaging formats. Supporting others close to the participants was the prominent intention of participants' health information access. Participants showed aspirations for an autonomous life by wanting to learn how to search.Research limitations/implicationsThe findings of this study provide some avenues for consumer health information access to be respectful and inclusive of users with intellectual disability, both from an accessible design perspective as well as from a learning and support standpoint.Originality/valueThis study complements other human–computer interaction (HCI) studies which observe how adults with intellectual disability can be supported to engage with web search; this study offers the adults' verbalized perspectives on how adults wish to interact with web searching for health information, nuanced by adults' existing abilities and support needs.
Asymmetric modeling of the public debt–economic growth nexus in Ghana
Authors: Abille Adamu Braimah , Kiliç Esin 
Published: December 2022

PurposeThe impact of debt on economic growth has attracted immense economic research necessitated by ballooning public debt stock among countries and most of the literature presume a symmetric relationship between debt and economic growth. However, this study contemplates an asymmetric relationship and thus relies on annual series from 1970 to 2019 to examine the asymmetric effects of public debt on economic growth in Ghana.Design/methodology/approachThe nonlinear autoregressive distributed lag (NARDL) bounds approach was employed. Gross domestic product (GDP) growth is the dependent variable while public debt and other control variables each decomposed into their positive and negative shocks constitute the independent variables.FindingsThe results reveal that a positive shock to public debt insignificantly impacts the growth of the economy in the short and long runs. Also, a negative shock to public debt exerts significant short-run negative and insignificant long-run positive effects on the growth of the economy. The divergence in the short- and long-run effects on growth of a negative shock to public debt and the general insignificant effects of a positive shock to the same is a glitch that is attributed to overcapitalized loans and poor utilization of credit facilities.Practical implicationsThe study recommends “inter alia” that the government of Ghana strengthens the short to medium-term debt management strategies achievable through the enforcement of the Public Financial Management Act (PFMA) Act-921 and the Public Procurement Act (PPA) Act-914 to deal with any adverse effects of debt on the growth of the economy.Originality/valueThe novelty of the current study lies not only in the fact that it captures recent public debt dynamics at a time Ghana faces extreme fiscal constraints and escalating cost of debt servicing but it also does so in an asymmetric environment which is unprecedented an assumption in the analysis of Ghana's public debt–economic growth nexus.
Visiting natural disaster sites as transformational experiences
Authors: Wang Jinwei , Xu Xiaowen , Lu Guangjuan , Wang Xin , Morrison Alastair M. 
Published: December 2022

Purpose
This study aims to investigate the perceived benefits arising from tourist activities at natural disaster sites, to analyze the influence of perceived benefits on satisfaction and behavioral intentions and to identify origin region’s moderating role.

Design/methodology/approach
A research model containing dark tourism motivations (DTMs), tourist perceived benefits (TPBs), tourist satisfaction (TS), protection intention (PI) and loyalty intention (LIs) was developed, and visitor origin was introduced as a moderating variable. Taking the 5·12 Wenchuan Earthquake Memorial Museum as a case site, data were obtained by distributing questionnaires on-site, and the model was tested using partial least squares-structural equation modeling (PLS-SEM).

Findings
DTMs had a significant effect on cognitive and affective benefits, and TPBs significantly affected TS, PI and LIs, with satisfaction playing a partial mediating role. The origins of tourists showed a moderating role in part of the influence relationship of perceived benefits.

Practical implications
This study explored the perceived benefits among dark tourists and built a research model of their influence on tourist satisfaction and behavior. This study not only provides suggestions for managers related to dark tourism development in natural disaster areas, but also offers the possibility of enhancing tourist dark tourism experiences by interpreting the psychology and behavior of dark tourists.

Originality/value
This research adopted a new perspective of the decision-making behavior of dark tourists. The perceived benefits arising from visiting natural disaster sites were analyzed and the relationships between TBSs and motivation, TS, PI and LIs were examined. Considering the specificity of dark tourism emotions, the research also analyzed the similarities and differences in the psychology and behavior of locals and non-locals in dark tourism. The research results enrich and deepen the theoretical study of dark tourism.
Determination of vehicle speed from recorded video using the open‐source software Kinovea
Authors: Paolino Saverio , Zampa Francesco 
Published: December 2022

AbstractVideo devices of different kind often record traffic accidents, including vehicle‐pedestrian collisions and hit‐and‐run accidents. In these cases, the vehicle speed is valuable information because it can assist the investigators in an accident reconstruction. This paper examines the use of Kinovea, an open‐source video annotation tool designed for sport analysis, to estimate vehicle speed in forensic videos. Kinovea does not require a complex methodology, and it can be used to make the calculation easily. A series of vehicle driving experiments using an appropriately calibrated speed radar system (so called Scout Speed) were carried out, and measurements were compared with the estimated speed. In controlled conditions, the comparison of Scout reference speed and calculated average vehicle speed by means of Kinovea found an average difference of 0.43 km/h, with a margin of error of ±0.64 km/h. In addition, further preliminary tests were carried out to check the reliability of the measurements under lower resolution conditions. Also, in these cases the calculations were in line with the ground truth. Therefore, in the tested conditions, Kinovea demonstrated to be an easy and reliable tool available for forensic video examiners. Further tests need to be conducted in order to address the applicability of the measurement technique with true CCTV/surveillance video recordings.