bluuebunny/crossref_metadata_2025_split huggingface dataset:
PD38 Telehealth Use To Fight The COVID-19 Pandemic In A Brazilian Private Healthcare System
Authors: Ribeiro Geraldo Jose Coelho , Cruvinel Horta Maria da Glória , Camelo Ricardo Mesquita , Beltrão Campos Nelson Otávio , de Oliveira Douglas Ribeiro , de Almeida Carvalho Lélia Maria , de Castro Zocrato Karina , dos Reis Daniel Pitchon , Fernandes Mariana Ribeiro , Terenzi Cunha Patrícia Liz , Dusanek Annemarie , Biscione Fernando Martín , Kelles Silvana 
Published: December 2022

IntroductionThe outbreak of the COVID-19 pandemic generated the need to adapt patients’ access to health services, given the rapid and exponential increase in demand at all levels of care, making social distancing one of the few weapons available in this fight. In this scenario, telehealth proved to be a fundamental tool in tracking and guiding patients with suspected or confirmed disease. This work presents the demographic profile of the people attended, the most prevalent clinical situations in care and the clinical outcomes of the remote care.MethodsThis was an observational, descriptive, cross-sectional, retrospective study carried out at Unimed Belo Horizonte, a medical work cooperative, from March 2020 to May 2021. We analyzed anonymized data on remote care from electronic medical records provided by the operator, with the remote contacts of these patients being spontaneous.ResultsIn the period evaluated, 380,663 remote calls were made, with a monthly average of 36,888 calls. Of these visits, 59.5% were carried out by women and 40.5% by men. There were, 13,211 (3.5%) consultations with patients aged 0 to 9 years, 19,933 (5.2%) 10 to 19 years, 319,882 (84%) in people aged 20 to 59 years, and 27,633 (7.3%) aged 60 years or older. There were 64,348 (17%) consultations in patients with confirmed COVID-19 and 40,997 (11%) with suspected COVID-19. There were 194,746 (51.2%) consultations due to respiratory complaints and 14% of consultations due to other causes, but whose initial care was due to signs and symptoms suggestive of COVID-19. Of people assisted remotely, 29,734 (7.8%) attended the emergency room within 3 days, while 38,685 (10.2%) sought the emergency room within 14 days. There were 2,846 (0.7%) consultations in the emergency room that resulted in the hospitalization of patients.ConclusionsTelehealth proved to be resolute and an important tool for accessing health services during the pandemic.
PD44 Realistic Review: Theoretical Model For Monitoring And Evaluation (M&E) Of Health Technology Assessment Management
Authors: De Assis Patroclo Maria Aparecida , Elias Flávia 
Published: December 2022

IntroductionRealistic Review (RR) is a methodology for systematic review proposed by Pawson (2002), to guide policy formulation. It is aimed at policy makers and decision makers and seeks to explain how a given intervention succeeds or fails in a certain context, allowing the identification of more suitable alternatives to solve problems. The objective of this study was to develop a theoretical model for Monitoring and Evaluation (M&E) of Health Technology Assessment (HTA) management.MethodsThe realistic review sought to identify aspects that influence HTA contributions. Studies were included if they provided a description of context and description of HTA contributions. Key purpose elements were extracted from selected studies and the contexts of HTA contributions were analyzed. The association between context and types and areas of contributions of HTA in different realities was synthesized. We analyzed thirty-one articles published in international journals in the area of health technology assessment and three articles on assessment policy in Brazil, nominated by experts.ResultsIt was possible to identify situations that generate demands for HTA; favorable and unfavorable contexts and factors for contributions; main functions of networks; main products resulting from the application of evaluations; results and impact predicted by the action of the networks.The logical model starts with conjunctural aspects that generate demands: economic, social and cultural. In a favorable context, the definition of priorities and debates in the negotiation arenas influence research and the policy formulation process. Networks identify evidence and contribute to knowledge management, generating products, results and impacts.ConclusionsThe use of the theoretical model created from the realistic review is a tool that allows the M&E of HTA management.
PD48 Does Unmet Need Influence The Scottish Medicines Consortium Health Technology Assessment Decisions For Rare Disease Conditions?
Authors: Mark Karen , Wahal Vishnu Priya 
Published: December 2022

IntroductionThe Scottish Medicines Consortium (SMC) defines end-of-life medicines as drugs used for treating conditions that usually lead to death within three years using currently available treatments. Orphan medicines are drugs used for the treatment of very rare conditions and ultra-orphan drugs are used for the treatment of extremely rare conditions. The objective of this study is to determine the influence of unmet need on SMC health technology assessment (HTA) decisions for rare disease conditions.MethodsThe reimbursement data between 2004 and 2021 from SMC for rare disease conditions were included. These data were categorized based on the presence of an unmet need, that is, drugs considered under the orphan or ultra-orphan process, or those that fulfilled SMC end-of-life criteria. A chi square test was conducted to determine an association between the presence of an unmet need and the HTA decision. HTAs without a decision were excluded.ResultsA total of 91 HTAs were included in the analysis of which, 57.1 percent (n = 52) were recommended, and 42.9 percent (n = 39) were not recommended. Out of the recommended reviews, 32.7 percent (n = 17) addressed an unmet need and 67.3 percent (n = 35) did not. Recommended drugs had positive clinical evidence and high cost-effectiveness or the submission of a patient access scheme while negative decisions were associated with lower or uncertain cost-effectiveness. The chi square test result showed no association between the presence of an unmet need and the HTA decision (p = 0.315).ConclusionsUnmet need does not influence the SMC HTA decisions for rare disease conditions. Economic elements were the driving factors in the decision-making process.
PD56 Conceptual Issues In The Valuation Of Health States In Children
Authors: Shah Koonal , Lipman Stefan , McNamara Simon , Mott David , Reckers-Droog Vivian , Schneider Paul , Coates Lizzie 
Published: December 2022

IntroductionAssessing the cost utility of health technologies for pediatric patients requires robust utility values for child health states, but the methods for valuing these pediatric health states are much less established than those for valuing adult health states. This is partly because the elicitation of preferences for child health states poses many normative, ethical, and practical challenges.MethodsThis presentation examines the conceptual issues in the valuation of health states in children by addressing the following questions.(i)Normative theories of health state values: What are we attempting to elicit?(ii)Sources of preferences: Whose preferences should we elicit, and from which perspective?(iii)Valuation methodologies: How should we elicit preferences?(iv)Attaching different values to child and adult health: Is a lack of consistency problematic?To answer these questions, we used desk research (non-systematic literature reviews) and findings from a two-part workshop held in April 2021. The workshop included 25 participants with expertise in health economics, health state valuation, child health, health technology assessment (HTA) decision-making, and ethics.ResultsWe identified a lack of consensus on what is being elicited for both adults and children. Many HTA agencies recommend that the public be involved in utility generation exercises, but some criteria for defining who constitutes a member of the public exclude children. Of the many candidate sample types, perspectives, and methodologies, only a few were deemed relevant, acceptable, and feasible for use in the child health context. In addition, there were diverging views on whether it is possible to compare and integrate adult and child value sets with different properties.ConclusionsSeveral questions remain to be answered before the public and other stakeholders can have confidence in child health state valuation protocols. We propose a research agenda, including both empirical and conceptual work, to inform future methodological development and to help HTA agencies make recommendations about how child utility values should be generated.
Collective labour rights of police officers: Global labour constitutionalism and militaristic labour constitutionalism
Authors: Litor Lilach 
Published: December 2022

AbstractCollective labour rights, including the right to organize and strike, were recognized in the principles of the International Labour Organization (ILO) as fundamental rights. Despite their importance, different countries enacted legislation that included a ban on police organization in trade unions or a ban just on police strikes. The right of police officers to organize and strike is of particular importance nowadays at a time of increased public scrutiny and large-scale protests over incidents of extra-judicial killing by police. There is a need to recognize collective rights for police officers in order to improve working conditions and organizational justice at work for them as a way of moderating officers’ perspectives of public hostility and improving their capability to carry out their duties. Another benefit of recognizing a right to organize is the union’s capacity to advance important values, including avoiding racism and violence and assuring the compliance of individual officers with the ethics and code of conduct expected from police officers. This article seeks to address the unique topic of the linkage between the collective labour rights of police officers and varieties of constitutionalism in these critical times. It introduces two potential approaches in this regard: (1) global labour constitutionalism; and (2) militaristic labour constitutionalism. The former implements international standards set by the ILO as a basis for constitutionalism while the latter emphasizes domestic issues and the need to maintain the public order and security of citizens. The article examines the possibility of applying global labour constitutionalism as a basis for recognizing collective rights for police officers.
Tomato and bell pepper tolerance to preemergence herbicides applied posttransplant in plasticulture production
Authors: Buzanini Ana C. , Boyd Nathan S. 
Published: December 2022

AbstractPreemergence (PRE) herbicides are often banded over the entire top of raised beds for broadleaf and grass control in plasticulture vegetable production systems. However, broadleaf and grass weeds may emerge from the planting holes and tears in the plastic mulch. Banded application results in herbicides applied where no holes occur, and therefore, where they are not needed. Our objective is to identify herbicides that do not harm transplanted crops when directed at transplant holes after transplant (POST) with the aim to reduce off-target applications. Therefore, we evaluated tomato and pepper tolerance to PRE herbicides applied to transplant holes 2 wk after transplant and the subsequent effects on crop tolerance and weed density. Halosulfuron, S-metolachlor, metribuzin, and pendimethalin did not injure tomato transplants, reduce height, or reduce yield. Fomesafen caused some tomato injury (7%) but had no effect on other measured parameters in Trial I. All PRE herbicides injured peppers by ≥19%, although no effect on yield was observed. Overall, halosulfuron, S-metolachlor, metribuzin, and pendimethalin can be safely applied to tomato transplant holes 2 wk after transplant with no significant crop injury nor effects on final yield, but none of the evaluated herbicides are safe for use on pepper crops.
Short‐Term and Long‐Term Variations in Seismic Velocity at Shallow Depths of the Overriding Plate West of the Japan Trench
Authors: Tonegawa T. , Takagi R. , Sawazaki K. , Shiomi K. 
Published: December 2022

AbstractLong‐term and short‐term temporal variations in seismic velocity have been investigated using seismic interferometry, and significant short‐term changes are typically recognized as velocity reductions caused by large earthquakes. In this study, using a dense network of ocean bottom seismometers (Seafloor Observation Network for Earthquakes and Tsunamis along the Japan Trench: S‐net), we measured temporal variations in seismic velocity at the top of the overriding plate in the region between the Japanese Islands and the Japan Trench. We detected abrupt velocity reductions due to the nearby Mw 7‐class earthquakes in 2016 and 2021, and gradual velocity increases mainly observed near the trench. The sudden velocity reductions due to the shallow earthquake in 2016 within the overriding plate are large above the hypocenter, while those due to the three deep earthquakes in 2021 are large near the trench, although these earthquakes occurred far from the trench. The three earthquakes are located at the top of and within the subducting oceanic crust of the Pacific Plate. The spatial distributions of the velocity reductions for the four earthquakes are consistent with those of the peak ground velocities (PGVs). This indicates that for the three deep earthquakes, seismic waves trapped within the descending Pacific Plate reach to the trench, and the trapped waves induce large PGVs, and hence substantially reducing the velocity. Long‐term variations observed near the trench are possibly caused by the recovery process of coseismic velocity reductions due to large earthquakes and/or fluid migration induced by the tectonic stress field in the region.
Contrasting Annual and Summer Phosphorus Export Using a Hybrid Bayesian Watershed Model
Authors: Karimi K. , Miller J. W. , Sankarasubramanian A. , Obenour D. R. 
Published: December 2022

AbstractNutrient pollution is a widespread environmental problem that degrades water quality worldwide. Addressing this issue calls for characterizing nutrient sources and retention rates, especially in seasons when water quality problems are most severe. Hybrid (statistical‐mechanistic) watershed models have been used to quantify nutrient loading from various source categories. However, these models are generally developed for long‐term average conditions, limiting their ability to assess temporal drivers of nutrient loading. They also have not been calibrated for season‐specific estimates of loading and retention rates. To address these issues, we developed a hybrid watershed model that incorporates interannual variability in land use and precipitation as temporal drivers of phosphorus loading and transport. We calibrate the hybrid watershed model within a Bayesian hierarchical framework on both an annual and summer basis over a multi‐decadal period (1982–2017). For our study area in the North Carolina Piedmont region (USA), we find that urban lands developed before 1980 are the largest contributor of phosphorus (per unit area), especially under dry conditions. Seasonally, summer phosphorus export rates are generally found to be lower than corresponding annual rates (kg/ha/mo), while in‐stream retention is found to be elevated in summer. In addition, we find that precipitation has a substantially larger influence on phosphorus export from agricultural lands than other source types, especially in summer, and that antecedent (May) precipitation significantly influences summer phosphorus export. Overall, our approach provides a data‐driven and probabilistic line of evidence to support watershed phosphorus management across different sources and seasons.
The effect of aging on glucose metabolism improvement after Roux-en-Y gastric bypass in type 2 diabetes rats
Authors: Chen Weijie , Yin Haixin , Xiao Jianchun , Liu Wei , Qu Qiang , Gong Fengying , He Xiaodong 
Published: December 2022

Abstract
Background
This study aimed to investigate the effect of aging on glucose metabolism improvement after Roux-en-Y gastric bypass (RYGB) in rat models with type 2 diabetes mellitus (T2DM).

Methods
Twenty aged Goto-Kakizaki rats were randomly assigned into RYGB-A group and sham RYGB (SR-A) group, and 10 adult Goto-Kakizaki rats also accept RYGB procedures (RYGB-Y). Glucose metabolism, resting energy expenditure (REE), glucagon-like peptide-1 (GLP-1) and total bile acid level were measured.

Results
RYGB could significantly improve glucose metabolism in aged diabetic rats. The fasting blood glucose level in the RYGB-A group decreased from 15.8 ± 1.1 mmol/l before surgery to 12.3 ± 1.5 mmol/l 16 weeks after surgery (P < 0.01), and the AUCOGTT value decreased from 2603.9 ± 155.4 (mmol/l) min to 2299.9 ± 252.8 (mmol/l) min (P = 0.08). The decrease range of fasting blood glucose in the RYGB-A group was less than that in the RYGB-Y group (20.5% ± 6.5% vs. 40.6% ± 10.6%, P < 0.01), so is the decrease range of AUCOGTT value (11.6% ± 14.8% vs. 38.5% ± 8.3%, P < 0.01). Moreover, at the 16th postoperative week, the increase range of REE of the RYGB-A group was lower than that of the RYGB-Y group (15.3% ± 11.1% vs. 29.1% ± 12.1%, P = 0.04). The increased range of bile acid of the RYGB-A group was less than that of the RYGB-Y group (80.2 ± 59.3 % vs.212.3 ± 139.0 %, P < 0.01). The GLP-1 level of the RYGB-A group was less than that of the RYGB-Y group (12.8 ± 3.9 pmol/L vs. 18.7 ± 5.6 pmol/L, P = 0.02). There was no significant difference between the RYGB-A group and the RYGB-Y group in the level of the triiodothyronine level.

Conclusions
RYGB could induce a glucose metabolism improvement in aged diabetic rats, and aging might moderate the effect of RYGB.
Monitoring the 5′UTR landscape reveals isoform switches to drive translational efficiencies in cancer
Authors: Weber Ramona , Ghoshdastider Umesh , Spies Daniel , Duré Clara , Valdivia-Francia Fabiola , Forny Merima , Ormiston Mark , Renz Peter F. , Taborsky David , Yigit Merve , Bernasconi Martino , Yamahachi Homare , Sendoel Ataman 
Published: December 2022

AbstractTranscriptional and translational control are key determinants of gene expression, however, to what extent these two processes can be collectively coordinated is still poorly understood. Here, we use Nanopore long-read sequencing and cap analysis of gene expression (CAGE-seq) to document the landscape of 5′ and 3′ untranslated region (UTR) isoforms and transcription start sites of epidermal stem cells, wild-type keratinocytes and squamous cell carcinomas. Focusing on squamous cell carcinomas, we show that a small cohort of genes with alternative 5′UTR isoforms exhibit overall increased translational efficiencies and are enriched in ribosomal proteins and splicing factors. By combining polysome fractionations and CAGE-seq, we further characterize two of these UTR isoform genes with identical coding sequences and demonstrate that the underlying transcription start site heterogeneity frequently results in 5′ terminal oligopyrimidine (TOP) and pyrimidine-rich translational element (PRTE) motif switches to drive mTORC1-dependent translation of the mRNA. Genome-wide, we show that highly translated squamous cell carcinoma transcripts switch towards increased use of 5′TOP and PRTE motifs, have generally shorter 5′UTRs and expose decreased RNA secondary structures. Notably, we found that the two 5′TOP motif-containing, but not the TOP-less,RPL21transcript isoforms strongly correlated with overall survival in human head and neck squamous cell carcinoma patients. Our findings warrant isoform-specific analyses in human cancer datasets and suggest that switching between 5′UTR isoforms is an elegant and simple way to alter protein synthesis rates, set their sensitivity to the mTORC1-dependent nutrient-sensing pathway and direct the translational potential of an mRNA by the precise 5′UTR sequence.
PCNA regulates primary metabolism by scaffolding metabolic enzymes
Authors: Røst Lisa M. , Ræder Synnøve B. , Olaisen Camilla , Søgaard Caroline K. , Sharma Animesh , Bruheim Per , Otterlei Marit 
Published: December 2022

AbstractThe essential roles of proliferating cell nuclear antigen (PCNA) as a scaffold protein in DNA replication and repair are well established, while its cytosolic roles are less explored. Two metabolic enzymes, alpha-enolase (ENO1) and 6-phosphogluconate dehydrogenase (6PGD), both contain PCNA interacting motifs. Mutation of the PCNA interacting motif APIM in ENO1 (F423A) impaired its binding to PCNA and resulted in reduced cellular levels of ENO1 protein, reduced growth rate, reduced glucose consumption, and reduced activation of AKT. Metabolome and signalome analysis reveal large consequences of impairing the direct interaction between PCNA and ENO1. Metabolites above ENO1 in glycolysis accumulated while lower glycolytic and TCA cycle metabolite pools decreased in the APIM-mutated cells; however, their overall energetic status were similar to parental cells. Treating haematological cancer cells or activated primary monocytes with a PCNA targeting peptide drug containing APIM (ATX-101) also lead to a metabolic shift characterized by reduced glycolytic rate. In addition, we show that ATX-101 treatments reduced the ENO1 - PCNA interaction, the ENO1, GAPDH and 6PGD protein levels, as well as the 6PGD activity. Here we report for the first time that PCNA acts as a scaffold for metabolic enzymes, and thereby act as a direct regulator of primary metabolism.
Real-world use of defibrotide for veno-occlusive disease/sinusoidal obstruction syndrome: the DEFIFrance Registry Study
Authors: Mohty Mohamad , Blaise Didier , Peffault de Latour Régis , Labopin Myriam , Bourhis Jean Henri , Bruno Benedicte , Ceballos Patrice , Detrait Marie , Gandemer Virginie , Huynh Anne , Izadifar-Legrand Faezeh , Jubert Charlotte , Labussière-Wallet Hélène , Lebon Delphine , Maury Sébastien , Paillard Catherine , Pochon Cécile , Renard Cecile , Rialland Fanny , Schneider Pascale , Sirvent Anne , Asubonteng Kobby , Guindeuil Gwennaëlle , Yakoub-Agha Ibrahim , Dalle Jean-Hugues 
Published: December 2022

AbstractVeno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially life-threatening complication of haematopoietic cell transplantation (HCT) conditioning. The DEFIFrance post-marketing registry study evaluated effectiveness and safety in patients who received defibrotide. It collected retrospective/prospective patient data from 53 French HCT centres from July 2014 to March 2020. Primary endpoints were survival and complete response (CR; total serum bilirubin <2 mg/dL, multiorgan failure resolution) at Day 100 post-HCT among patients with severe/very severe VOD/SOS. A secondary endpoint was evaluation of treatment-emergent serious adverse events (TESAEs) of interest. Of 798 patients analysed, 251 and 81 received defibrotide treatment for severe/very severe VOD/SOS and mild/moderate VOD/SOS post-HCT, respectively; 381 received defibrotide for VOD/SOS prophylaxis. In patients with severe/very severe VOD/SOS post-HCT, Kaplan–Meier–estimated CR at Day 100 was 74% (95% confidence interval [CI]: 66%, 81%). At Day 100, 137/251 (55%) were alive and in CR. Kaplan–Meier–estimated Day 100 post-HCT survival was 61% (95% CI: 55%, 67%) in patients with severe/very severe VOD/SOS. TESAEs of interest occurred in 29% of these patients; VOD/SOS-related mortality at 12 months was 15%. DEFIFrance represents the largest collection of real-world data on post-registration defibrotide use, supporting the real-world utility of defibrotide for patients with severe/very severe VOD/SOS post-HCT.