bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Relational Transgression and Its Consequences in J.M Coetzee’S Novel Disgrace
Authors: Pardi Pardi , Manugeren M. , Zein T. Thyrhaya , Pratiwy Devi , Asnani Asnani , Hidayati Hidayati 
Published: January 2025

Abstract. J.M. Coetzee's Disgrace's relational transgression analysis is essential to comprehending literary analysis, ethical ramifications, society impact, and human behavior. People can learn more about the reasons behind such offenses, as well as the psychological and sociological elements that play a role by analyzing David Lurie's acts and the effects they have.This research aims to analyze the relation transgression committed by the character David Lurie in J.M. Coetzee's novel Disgrace and to delve deeper into why individuals engage in actions that breach social norms and how such actions impact individuals and society. Using a literary psychology approach through a descriptive qualitative research method, this study reveals the dominant characteristics of Lurie that trigger relation transgression. The whole research is conducted by means of descriptive qualitative research method using content analysis. The analysis results show that Lurie has a tendency to violate social norms, particularly concerning his sexual desires. His arrogance and reluctance to apologize exacerbate the situation and isolate him from his social environment. This research contributes to a deeper understanding of the complexity of characters in literary works and the implications of violating relational bonds in individual lives. By referring to the theory of relational transgression, this research highlights how Lurie's actions not only impact himself but also those around him. Effective preventive and intervention techniques may be developed with the help of the examination of Lurie's relational transgression in Disgrace. Communities can be made safer, healthier, and more inclusive by educating people on the underlying causes and effects of such behavior. By understanding the root causes and consequences of relational transgression, it is hoped that more effective prevention and intervention strategies can be developed.Keywords: Apology; arrogance; relation transgression; sexual desire
A CRITICAL EVALUATION OF TONY BLAIR’S LABOUR GOVERNMENT’S POLICIES TOWARDS EUROPEAN UNION
Authors: P. S. Balasubramanya 
Published: January 2025

This paper mainly explains the United Kingdom and European Union relations during Tony Blair’s period. After UK’s membership to the EU in 1973, it had not actively engaged in the European Union’s policy initiatives and implementation process. From 1973 to 1996, the successive UK Prime Ministers followed a negative and sceptical attitude towards various EU policy initiatives and none of the UK Prime Ministers showed any special interest in improving its relations with the EU. At this juncture, Tony Blair’s Labour government made a huge difference in the European Union and United Kingdom’s relationship. In this context, the study of Tony Blair’s New Labour government’s policies and perspectives towards the European Union gives a better understanding of the United Kingdom and European Union’s relations during that period.
Optimizing patients’ outcomes: A comparative study of angiography and angioplasty procedures.
Authors: Shams ul Islam  , Faiz Ullah  , Abdullah  , Sajjad Khan  , Fazal Amin  , Abdul Salar Khan  
Published: January 2025

Objective: To compare angiography and angioplasty, assess how they affect patient outcomes, and pinpoint variables that could maximize each procedure. Study Design: Retrospective Cohort study. Setting: Afridi Medical Complex (AMC). Period: Jan. 2021 to Jan 2022. Methods: Comparing the outcomes of patients who underwent coronary angiography and those who underwent percutaneous coronary intervention (PCI), commonly referred to as angioplasty. Patients included adult patients aged 18 years and older who were diagnosed with CAD and underwent either coronary angiography or angioplasty procedures. Those with incomplete medical records, emergency revascularization, and concomitant procedures such as coronary artery bypass grafting (CABG) were excluded. Results: A total of 150 patients were included in this study, with a mean age of participants (57 ± 15.345), male predominance 67% compared to females 33%. Of the total population, 19.3% presented with dyslipidemia. Comparative analysis of angiography and percutaneous coronary intervention (PCI) procedures reveals notable differences in outcomes and complications. Cardiogenic shock was significantly more frequent in the PCI group 3.5% compared to the angiography group 2%, with a p-value of 0.04 indicating statistical significance. Conclusion: In conclusion, while angioplasty offers significant advantages in terms of symptom relief and functional outcomes, the role of angiography in diagnostic precision cannot be understated. Both procedures have distinct benefits and risks, and their use should be tailored to individual patient needs.
TFL1-like genes in Vigna unguiculata (L.) Walp. with different growth habit types
Authors: Krylova E. A. , Khlestkina E. K. 
Published: January 2025

Background. Vigna unguiculata (L.) Walp. is among important legume crops. Agricultural producers prefer cultivars suitable for mechanized cultivation, with a determinate growth habit type. Plant architectonics depends on the functioning of the apical meristem, while the transition to the reproductive stage is controlled by a set of genes, including the TFL1 gene. Analyzing the genes responsible for the growth habit type is relevant for more efficient and rapid development of high-tech cultivars. Materials and methods. Using the Sanger DNA sequencing method, the primary structure of TFL1-like genes was studied in six cowpea accessions with different growth habit types and architectonics.Results. Promoter regions and coding parts of TFL1-like genes (VuTFL1.1, VuTFL1.2, VuATC, and VuBFT) were sequenced and analyzed. Information about the genes is available in the NCBI nucleotide sequence database. A comparative study showed that there were no exon differences between different genotypes. Rearrangements were found in the introns and the promoter region, but no relationship was traced between these rearrangements and the phenotype in terms of growth habit types or architectonics.Conclusion. The next step towards understanding the role of TFL1-like genes requires obtaining knockout lines based on these genes and studying their phenotype. Meanwhile, the results of this analysis call for a need to consider a wider range of cowpea genes potentially associated with the variability of stem growth habit types and plant architectonics.
The OsGATA gene family as a promising candidate for applying the CRISPR/Cas genome editing technology to improve the nutritional and yield qualities of rice (Oryza sativa L.)
Authors: Nesterova E. A. , Shvachko N. A. 
Published: January 2025

Molecular breeding of rice (Oryza sativa L.) for yield is of great importance for ensuring food security of the population. Living organisms manifest genetically determined responses to environmental factors, including stressors. Photosynthetic activity affects all metabolic processes in plant cells. The genes involved in photosynthesis, in their turn, are regulated by differentially expressed genes associated with circadian rhythms. Plants, as sedentary organisms, require more efficient regulation of gene expression. GATA factors are transcription factors (TFs) that affect the production of phytohormones and mediate the stress response. GATA factors are divided into four main classes (A to D), based on the difference in the structure of the zinc finger domain, and into seven subfamilies, depending on the availability of additional domains. GATA TFs incorporate domain structures that may be involved in the regulation of circadian rhythms. Effects on the circadian rhythms influence other regulatory metabolic pathways in plants, which makes the study of genes associated with circadian rhythms relevant and significant. The most well-known and popular method of gene editing at the moment is the CRISPR/Cas technology. More than 30 rice genes were successfully genomically edited using the CRISPR/Cas technology in the period from 2018 through 2023. This helped to improve their valuable agronomic traits.This review summarizes all information about the classification and known functions of OsGATA genes and OsGATA TFs and provides evidence for the possibility of influencing the regulation of rice photoperiodicity by editing these genes.
Influence of seeding rates on the quantum yield of photosynthesis for some field crops
Authors: Panchenko K. S. , Ovcharova N. V. , Sokolova L. V. , Silantyeva M. M. 
Published: January 2025

Background. Photosynthesis is one of the most important physiological processes in plants, affecting the productivity of agrocenoses. Creating conditions for crops to absorb and convert solar energy as effectively as possible can be a means of increasing their yields. The objective was to study the production processes and stress resistance of some crop species in order to optimize their cultivation technology.Materials and methods. The work was carried out in the steppe and forest-steppe zone of Altai Territory. The scheme of the experiment was conducive to studying the quantum yield of photosynthesis as a method for assessing various seeding rates in the fields of sunflower grown for seeds (‘Pioneer LE 10’) and maize grown for silage (‘Clifton’). For sunflower, the rates were 35,000, 45,000, and 55,000 seeds/ha; for maize, 40,000, 50,000, and 60,000 seeds/ha. The state of the photosynthetic apparatus in plants was analyzed using the JUNIOR-PAM fluorometer (Walz, Germany) in the main phases of plant development. results. The quantum yield of photosynthesis over the growing season of sunflower, depending on the seeding rate, was the highest during flowering and ripening (up to 0.81 relative units). The highest values of the quantum yield of photosynthesis for maize were recorded in the phases of the 2nd leaf and 6–8 leaves (0.63 and 0.64 relative units, respectively).Conclusion. The most effective development of sunflower plants, characterized by a high quantum yield of photosynthesis and high productivity, was observed at the seeding rate of 45,000 seeds/ha. The highest maize harvest for silage (1.56 t/ha) was registered under conditions favorable for this indicator at the rate of 50,000 seeds/ha. The correlation coefficient between the quantum yield of photosynthesis and crop yield was 0.7–0.8, which confirmed the dependence between those indicators and made it possible to determine the optimal sowing structure.
Some special features of the water regime and the photosynthetic apparatus functioning in garden roses under drought conditions
Authors: Pilkevich R. A. , Plugatar S. A. , Gubanova T. B. 
Published: January 2025

Data are presented on changes in the total water content in leaf tissues and the level of real water deficiency in 7 genotypes of garden roses (Rosa gallica L., R. odorata var. gigantea × R. multiflora, R. hugonis Hemsl., R. chinensis var. minima (Sims) Voss., R. bracteata J.C. Wendl., and R. foetida var. persiana (Lem.) Rehder) and cv. ‘Borisfen’ during the summer seasons of 2022–2023 on the Southern Coast of Crimea. Most genotypes showed a sublethal limit of water deficiency with the loss of 22–26% of water in their leaves. The leaf water regime was described for the studied genotypes under the extreme drought of 2023. For R. gallica, the critical limit of water loss was 10–15%. Simulating conditions close to the hot dry wind (t = 27°C, Rh = 30%) resulted in a more intensive loss of moisture by the leaves of the studied roses, while only R. odorata var. gigantea × R. multiflora showed a reduction in water consumption. The threshold for sublethal moisture deficiency in the leaves of relatively resistant plants (cv. ‘Borisfen’ and R. hugonis) dropped to 20–24%.Analyzing main parameters of chlorophyll fluorescence induction proved that the development of water deficiency in the range of 20–25% under low air humidity caused an irreversible inactivation of PS II in R. bracteata, R. gallica, and R. odorata var. gigantea × R. multiflora. Disturbances in the functioning of the photosynthetic apparatus in cv. ‘Borisfen’, R. hugonis, and R. foetida var. persiana were reversible. The variable fluorescence level and the fluorescence decay rate are informative for determining the degree of drought resistance in garden rose plants.
The production process of spring wheat plants in the system of biological agriculture
Authors: Shuliko N. N. , Yusova O. A. , Kiselyova A. A. , Tukmacheva E. V. , Yusov V. S. , Kubasova E. V. , Korchagina I. A. , Timokhin A. Yu. 
Published: January 2025

Background. Analyzing photosynthetic processes in a plant makes it possible to opine on the rate of its growth and development. In addition to classical physiological techniques, an interest is currently growing in spectrometry, which provides a realtime opportunity, based in the values of vegetation indices, to find out whether a plant is under stress or not.Materials and methods. Spring bread wheat cvs. ‘Omskaya 42’, ‘Omskaya 44’, and ‘Tarskaya 12’, and spring durum wheat cv. ‘Omsky Korall’ were analyzed in Western Siberia. Seeds were bacterized before sowing with an inoculant of diazotrophs belonging to Arthrobacter mysorens 7 and Flavobacterium sp.Results. Identification of increased plant growth and development rates is possible with the following vegetation indices in the ear emergence phase: TCARI = 27.32, MCARI = 106.4, SPAD = 40.6, CPHLT = 25.02, CPHLB = 14.5, CPHLA = 8.46, and CCI = 27.5, and those in the grain filling phase: CPHLT = 10.4, CPHLB = 7.2, and CPHLA = 4.7. The highest nitrogen-fixing activity level was observed in the rhizosphere of bread wheat cv. ‘Omskaya 42’ and durum wheat cv. ‘Omsky Korall’, amounting to 150.7–322.0 and 140.0–393.0 nM C2H4/100 g of soil, respectively, with the introduction of Arthrobacter mysorens 7 bacteria, and 149.0–281.0 and 86.2–554.5 nM C2H4/100 g of soil, respectively, with Flavobacterium sp.Conclusion. Consistently high values of the associative nitrogen fixation process were recorded in the variants involving bacterization of wheat seeds of cvs. ‘Omskaya 42’ and ‘Omsky Korall’ with the stimulating fungicide drugs Mizorin and Flavobacterin. According to the values of the TCARI and SPAD indices, it is possible to opine on the potential nitrogen-fixing activity and the yield of a cultivar.
Incidence of idiopathic syrinx in pediatric patients diagnosed with VACTERL association
Authors: Papadakis Joanna E. , Weber Daniel , Albanese John S. , Birch Ashley K. , Warf Benjamin 
Published: January 2025

OBJECTIVE
While the association of a syrinx with a tethered spinal cord in the context of VACTERL (vertebral defects [V], imperforate anus or anal atresia [A], cardiac malformations [C], tracheoesophageal defects [T] with or without esophageal atresia [E], renal anomalies [R], and limb defects [L]) association is known, the incidence of idiopathic syrinxes among these patients has not previously been reported. The authors aimed to characterize the incidence of syrinxes and the pattern of congenital anomalies in pediatric patients with VACTERL association, with a specific focus on the presence of idiopathic syrinxes in this population.

METHODS
An institutional database was retrospectively queried for all pediatric patients with VACTERL association. Patients were assessed for the presence of a syrinx. Those with no accompanying lesion to which the syrinx could be ascribed were designated idiopathic. Descriptive statistics and qualitative analyses characterized the clinical presentation and outcomes of this population.

RESULTS
The authors retrospectively identified 186 patients between 1993 and 2023 with VACTERL association. Of these 186 patients, 141 (75.8%) had a tethered spinal cord and 44 (23.7%) had a syrinx. Most syrinxes could be ascribed to the presence of a tethered spinal cord and/or Chiari malformation; however, 4 (9.1%) of the 44 appeared idiopathic, suggesting the incidence of idiopathic syrinxes in this patient population may be as high as 2.2% (4/186). Most patients remained asymptomatic aside from a single patient who presented with mild gait dysfunction that resolved over time. All syrinxes were managed conservatively, and all but one decreased or remained stable in size on follow-up imaging.

CONCLUSIONS
Although limited, current estimates suggest the general incidence of an idiopathic syrinx is between 5.6 and 8.4 per 100,000 people; these findings in a pediatric cohort with VACTERL association suggest an incidence of 2200 per 100,000 (i.e., 2.2%). Thus, an idiopathic syrinx may be 200–400 times as prevalent in the pediatric VACTERL population.
Clinical outcomes and cost-utility analysis of GKRS plus TKIs versus TKIs in patients with EGFR-mutant lung adenocarcinoma and brain metastases: a Markov decision model
Authors: Liu Szu-Hao Andrew , Lee Cheng-Chia , Yang Huai-Che , Huang Wei-Lun , Huang Yu-Hsien , Chung Wen-Yuh , Shi Hon-Yi 
Published: January 2025

OBJECTIVE
This study focuses on epidermal growth factor receptor–mutated lung adenocarcinoma, known for frequent brain metastasis. It aimed to compare the clinical outcomes and cost-effectiveness of combining Gamma Knife radiosurgery (GKRS) with tyrosine kinase inhibitors (TKIs) (GKRS+TKI group) versus TKIs alone (TKI group) for the treatment of patients with newly diagnosed brain metastasis in this condition.

METHODS
Study characteristics of the two groups were matched using inverse probability of treatment weighting (IPTW). In the incremental cost-utility ratio (ICUR) model, a healthcare provider perspective, a 1-month cycle length, a 5-year time horizon, and a discount rate of 2% per year for both effectiveness and costs were adopted. Probabilistic and one-way sensitivity analyses were also conducted to demonstrate the robustness of the findings. Statistical analysis was performed using IBM SPSS version 23.0, and cost-effectiveness analysis was conducted using TreeAge Pro software.

RESULTS
After applying IPTW, the GKRS+TKI group included 205 patients, and the TKI group consisted of 102 patients, with no statistically significant differences in whole confounders. The GKRS+TKI group demonstrated significantly prolonged median progression-free survival (37.5 months vs 10.6 months, p < 0.001) and median overall survival (55.1 months vs 30.8 months, p < 0.001) compared with the TKI group. The GKRS plus TKI strategy achieved an ICUR of $30,532.25 per quality-adjusted life year relative to the TKIs at the willingness-to-pay threshold of US$33,059 (Taiwan’s per capita gross domestic product).

CONCLUSIONS
The use of GKRS plus TKIs not only reduces disease recurrence and improves prognosis but also demonstrates a higher level of cost-effectiveness. These findings offer valuable guidelines for clinicians and inform healthcare authorities in optimizing resource allocation for improved medical care.
Bridging thrombolysis versus direct endovascular treatment in acute vertebrobasilar artery complex occlusion
Authors: Zhang Feng , Zhang Pan , Zhong Jinghui , Xiao Lulu , Xu Yingjie , Liu Dezhi , Jiang Yongjun , Wu Li , Dai Zheng , Zhu Juehua , Huang Zhixin , Liu Xinfeng , Sun Wen 
Published: January 2025

OBJECTIVE
Endovascular treatment (EVT) is an effective treatment for patients with acute vertebrobasilar artery complex occlusion (VBAO). However, the benefit of bridging thrombolysis prior to EVT remains controversial. The purpose of the present study is to explore the best treatment strategy between bridging treatment (BT) and direct EVT in patients with acute VBAO.

METHODS
Patients with acute VBAO who underwent EVT within 24 hours of estimated occlusion in a nationwide retrospective registry at 65 stroke centers in 15 provinces in China from December 2015 to June 2022 were retrospectively analyzed. The outcomes of the BT and direct EVT groups were compared using propensity score matching (PSM) and inverse probability of treatment weighting (IPTW). The primary outcome was favorable functional outcome, defined as a 90-day modified Rankin Scale (mRS) score of 0–3. Secondary outcomes included 90-day functional independence (mRS score 0–2), mRS score shift, in-hospital mortality, successful reperfusion, and symptomatic intracranial hemorrhage (sICH). In addition, a meta-analysis integrating currently available evidence was performed to make a systematic comparison between the two treatment strategies.

RESULTS
A total of 2353 patients were ultimately included; 447 of these patients received BT and 1906 received direct EVT. In both the original cohort and in the 1:1 PSM analysis, patients in the BT group had a significantly higher rate of favorable functional outcome (adjusted odds ratio [aOR] 1.41, 95% CI 1.14–1.76 for the original cohort and aOR 1.44, 95% CI 1.07–1.92 for 1:1 PSM). Regarding secondary outcomes, patients with BT had a significantly lower rate of in-hospital mortality (aOR 0.67, 95% CI 0.51–0.88 for the original cohort and aOR 0.69, 95% CI 0.48–0.99 for 1:1 PSM) and a shift toward better outcomes on the mRS (aOR 1.35, 95% CI 1.12–1.63 for the original cohort and aOR 1.31, 95% CI 1.03–1.69 for 1:1 PSM). However, there were no significant differences in functional independence, successful reperfusion, and sICH between the two groups. A meta-analysis, which included 22 studies involving 6579 patients, also revealed the superiority of BT over direct EVT on favorable functional outcome (OR 1.19, 95% CI 1.03–1.37, I2 = 0.00%; p = 0.02).

CONCLUSIONS
This matched-control study and meta-analysis suggest that compared with direct EVT, BT may be associated with better functional outcomes in patients with acute VBAO treated within 24 hours of estimated occlusion.