bluuebunny/crossref_metadata_2025_split huggingface dataset:
A National Study of Expedited Partner Therapy Use in Emergency Departments: A Survey of Medical Director Knowledge, Attitudes and Practices
Authors: Solnick Rachel E , Cortes Rafael , Chang Ethan , Dudas Paul , Deng Daxuan , Jamison Cornelius , Mmeje Okeoma , Kocher Keith E. 
Published: April 2023

AbstractBackgroundEmergency departments (EDs) are the primary source of healthcare for many patients diagnosed with sexually transmitted infections (STIs). Expedited partner therapy (EPT), treating the partner of patients with STIs without an exam of the partner, is an evidence-based practice for patients who might not otherwise seek care. Little is known about EPT use in the ED. In a national survey, we describe ED medical directors’ knowledge, attitudes, and practices of EPT.MethodsA cross-sectional internet survey of medical directors from academic EDs using the Academy of Academic Administrators of Emergency Medicine (AAAEM) Benchmarking Group from July through September 2020. Primary outcomes were EPT awareness, support, and use. The survey also examined barriers and facilitators. Multivariable regressions explored predictors of EPT support.ResultsForty-eight of 70 (69%) medical directors responded, representing EDs with a median volume of 67,840 patients/year. Awareness of EPT was high (73%), but fewer knew how to prescribe it (38%), and only 19% of EDs had implemented EPT. Most (79%) supported EPT and were more likely to if they were aware of EPT (89% vs. 54%) p=0.01. Of non-implementers, 41% thought EPT was feasible, and 56% thought departmental support would be likely. Of potential barriers, ED directors were most concerned about legal liability (25% moderately to extremely). Benefits of EPT were rated with similar importance, with preventing sequelae of untreated STIs most frequently rated as “extremely important” (44%). Linear regression showed increased years in practice, and ED’s proportion of Medicaid patients was significantly positively associated with support for EPT.ConclusionED medical directors expressed strong support for EPT and reasonable levels of feasibility for implementation but low utilization. Our findings highlight the need to identify mechanisms for EPT implementation and develop ED-tailored implementation tools to bolster this practice.
RNA landscapes of brain tissue and brain tissue-derived extracellular vesicles in simian immunodeficiency virus (SIV) infection and SIV-related central nervous system pathology
Authors: Huang Yiyao , Abdelgawad Ahmed , Turchinovich Andrey , Queen Suzanne , Abreu Celina Monteiro , Zhu Xianming , Batish Mona , Zheng Lei , Witwer Kenneth W. 
Published: April 2023

AbstractIntroductionAntiretroviral treatment regimens can effectively control HIV replication and some aspects of disease progression. However, molecular events in end-organ diseases such as central nervous system (CNS) disease are not yet fully understood, and routine eradication of latent reservoirs is not yet in reach. Brain tissue-derived extracellular vesicles (bdEVs) act locally in the source tissue and may indicate molecular mechanisms in HIV CNS pathology. Regulatory RNAs from EVs have emerged as important participants in HIV disease pathogenesis. Using brain tissue and bdEVs from the simian immunodeficiency virus (SIV) model of HIV disease, we profiled messenger RNAs (mRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), seeking to identify possible networks of RNA interaction in SIV infection and neuroinflammation.MethodsPostmortem occipital cortex tissue were collected from pigtailed macaques: uninfected controls and SIV-infected subjects (acute phase and chronic phase with or without CNS pathology). bdEVs were separated and characterized in accordance with international consensus standards. RNAs from bdEVs and source tissue were used for sequencing and qPCR to detect mRNA, miRNA, and circRNA levelsResultsMultiple dysregulated bdEV RNAs, including mRNAs, miRNAs, and circRNAs, were identified in acute infection and chronic infection with pathology. Most dysregulated mRNAs in bdEVs reflected dysregulation in their source tissues.These mRNAs are disproportionately involved in inflammation and immune responses, especially interferon pathways. For miRNAs, qPCR assays confirmed differential abundance of miR-19a-3p, let-7a-5p, and miR-29a-3p (acute SIV infection), and miR- 146a-5p and miR-449a-5p (chronic with pathology) in bdEVs. In addition, target prediction suggested that several circRNAs that were differentially abundant in source tissue might be responsible for specific differences in small RNA levels in bdEVs during SIV infection.ConclusionsRNA profiling of bdEVs and source tissues reveals potential regulatory networks in SIV infection and SIV-related CNS pathology.
Mast cells are upregulated in Hidradenitis Suppurativa Tissue, associated with epithelialized tunnels and normalised by Spleen Tyrosine Kinase Antagonism
Authors: Flora A , Jepsen R , Kozera EK , Woods JA , Cains GD , Radzieta M , Jensen SO , Malone M , Frew JW 
Published: April 2023

ABSTRACTMast cells have traditionally been associated with allergic inflammatory responses; however they play important roles in cutaneous innate immunity and wound healing. The Hidradenitis Suppurativa tissue transcriptome is associated with alterations in innate immunity and wound healing associated pathways, however the role of Mast cells in the disease is unexplored. We demonstrate that Mast cell associated gene expression (using whole tissue RNAseq) is upregulated, and in-silico cellular deconvolution identifies activated mast cells upregulated and resting mast cells downregulated in lesional tissue. Tryptase/Chymase positive Mast cells (identified using IHC) localize adjacent to epithelialised tunnels, fibrotic regions of the dermis and at perivascular sites associated with Neutrophil Extracellular Trap formation and TNF-alpha production.Treatment with Spleen Tyrosine Kinase antagonist (Fostamatinib) reduces the expression of mast cell associated gene transcripts, associated biochemical pathways, and number of tryptase/chymase positive mast cells in lesional hidradenitis suppurativa tissue.This data indicates that although Mast cells are not the most abundant cell type in Hidradenitis Suppurativa tissue, the dysregulation of mast cells is associated with B cell/plasma cell inflammation, inflammatory epithelialized tunnels and epithelial budding. This provides an explanation as to the mixed inflammatory activation signature seen in HS, the correlation with dysregulated wound healing and potential pathways involved in the development of epithelialized tunnels.
APART-QSM: an improved sub-voxel quantitative susceptibility mapping for susceptibility source separation using an iterative data fitting method
Authors: Li Zhenghao , Feng Ruimin , Liu Qiangqiang , Feng Jie , Lao Guoyan , Zhang Ming , Li Jun , Zhang Yuyao , Wei Hongjiang 
Published: April 2023

AbstractThe brain tissue phase contrast in MRI sequences reflects the spatial distributions of multiple substances, such as iron, myelin, calcium, and proteins. These substances with paramagnetic and diamagnetic susceptibilities often colocalize in one voxel in brain regions. Both opposing susceptibilities play vital roles in brain development and neurodegenerative diseases. Conventional QSM methods only provide voxel-averaged susceptibility value and cannot disentangle intravoxel susceptibilities with opposite signs. Advanced susceptibility imaging methods have been recently developed to distinguish the contributions of opposing susceptibility sources for QSM. The basic concept of separating paramagnetic and diamagnetic susceptibility proportions is to include the relaxation ratewithin QSM. The magnitude decay kernel, describing the proportionality coefficient betweenand susceptibility, is an essential reconstruction coefficient for QSM separation methods. In this study, we proposed a more comprehensive complex signal model that describes the relationship between 3D GRE signal and the contributions of paramagnetic and diamagnetic susceptibility to the frequency shift andrelaxation. The algorithm is implemented as a constrained minimization problem in which the voxel-wise magnitude decay kernel and sub-voxel susceptibilities are determined alternately in each iteration until convergence. The calculated voxel-wise magnitude decay kernel could realistically model the relationship between therelaxation and the volume susceptibility. Thus, the proposed method effectively prevents the errors of the magnitude decay kernel from propagating to the final susceptibility separation reconstruction. Phantom studies,ex vivomacaque brain experiments, andin vivohuman brain imaging studies were conducted to evaluate the ability of the proposed method to distinguish paramagnetic and diamagnetic susceptibility sources. The results demonstrate that the proposed method provides state-of-the-art performances for quantifying brain iron and myelin compared to previous QSM separation methods. Our results show that the proposed method has the potential to simultaneously quantify whole brain iron and myelin during brain development and aging.The proposed model was also deployed with multiple-orientation complex GRE data input measurements, resulting in high-quality QSM separation maps with more faithful tissue delineation between brain structures compared to those reconstructed by single-orientation QSM separation methods.
Ciliary protein CEP290 regulates focal adhesion via microtubule system in non-ciliated cells1
Authors: Matsuo Kazuhiko , Nakajima Yoshiro , Shigeta Masaki , Kobayashi Daisuke , Sakaki Shinichiro , Inoue Satoshi , Takeshita Naoki , Ueyama Atsuko , Nishikawa Kousuke , Saba Rie , Yokoyama Takahiko , Yashiro Kenta 
Published: April 2023

AbstractAlmost all differentiated mammalian cells have primary cilia on their surface. Ciliary dysfunction causes ciliopathy in humans. Centrosomal protein 290 (CEP290) is a ciliary protein that causes ciliopathies, localizes at the cilial base in ciliated cells, whereas it localizes to the centrosome in non-ciliated proliferating cells. The cilia-dependent function of CEP290 has been extensively studied; however, the cilia-independent function, which is likely responsible for the wider phenotypic spectra of CEP290-related ciliopathies, remains largely unknown. Here, we examined cilia-independent functions of CEP290 in non-ciliated cells. Our study showed thatCep290function loss suppresses microtubule elongation due to microtubule organizing center malfunction. Surprisingly, CEP290 forms a complex with the adenomatous polyposis coli (APC) protein encoded by theadenomatous polyposis coligene. The APC-CEP290 complex exists in the centrosome and on microtubule fibers. Notably, the reduced focal adhesion formation is likely responsible for theCep290mutant phenotypes, including impaired directed cell migration, shrunken cell shape, and reduced adhesive capacity to the extracellular matrix. The APC-CEP290 complex is consistently important for transporting a focal adhesion molecule, paxillin, to focal adhesions in non-ciliated cells. Thus, our findings provide a novel platform to better understand the ciliopathies.
Remotely sensed normalized difference red-edge index for rangeland biomass estimation
Authors: Sharifi Alireza , Felegari Shilan 
Published: April 2023

Purpose
The purpose of this study is rangeland biomass estimation and its spatial–temporal dynamics. Remote sensing has been a significant method for estimating biomass in recent years. The connection between vegetation index and field biomass will be used to assign probabilities, but in some cases, it does not provide acceptable results because of soil background and geographical and temporal variability.

Design/methodology/approach
In this study, the normalized difference red-edge (NDRE) index was used to calculate the rangeland biomass in comparison to five vegetation indices. Field measurements of biomass of natural rangeland in the West of Iran were taken in 2015, 2018 and 2021, and SENTINEL-2 data were used for analysis.

Findings
The results indicated that the overall advantage of NDRE stems from the fact that it adjusts for changes in leaf water content while overcoming the detrimental effects of soil substrate heterogeneity, both of these factors have a significant impact on pasture biomass. These results suggest that an NDRE-based biomass estimation model might be useful for estimating and monitoring biomass in large rangelands with significant geographical and temporal variability.

Originality/value
Identifying the best vegetation index to establish a vegetation-based biomass regression model for rangelands in large areas with different climatic conditions, plant compositions and soil types is the overall aim of this study.
Experimental study on the tribological behavior of ceramic disks for application in mixer taps under different lubrication conditions
Authors: Ziegler Marlene Kristin , Rothammer Benedict , Bartz Marcel , Wartzack Sandro , Beau Patrick , Patzer Gregor , Henzler Stephan , Marian Max 
Published: April 2023

Purpose
The evaluation of the haptics of water taps and wear-related changes during usage usually involves time- and cost-intensive testing. The purpose of this paper is to abstract the tribo-system between technical ceramic disks of water tap mixer cartridges to the model level and study the tribological behavior.

Design/methodology/approach
The friction and wear behavior was studied by means of an alumina ball-on-original alumina disk setup at different temperatures as well as under dry conditions and under lubrication by different greases. Thereby, the frictional behavior was measured in situ, and the wear losses were analyzed by means of laser scanning microscopy.

Findings
It was shown that friction and wear can behave in a contrasting way, whereby one grease might lead to low friction, that is, an easy-going movability of the water tap, but to increased wear losses. The latter, in turn, is an indicator for the usability and service life, which cannot be explained from friction alone. Thereby, the viscosity of the base oil, the grease consistency and additives were identified as relevant grease formulation parameters to allow for fluid film (re-)formation and removal of wear particles.

Originality/value
To the authors’ best knowledge, this is the first approach to systematically analyze the friction and wear behavior of technical ceramic disks of water tap mixer cartridges in dependency on the temperature as well as the used lubricating grease. This approach is relevant for developing screening test strategies as well as for the selection of lubricants for water tap applications.

Peer review
The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-11-2022-0334/
Entrepreneurship education and entrepreneurial communities in India: does gender really play a role?
Authors: Joshi Maheshkumar P. , Pandit Deepak , Tiwari Shalini Rahul , Choudhary Archana 
Published: April 2023

Purpose
Using the extant literature review, this paper aims to explore the relationship between gender, entrepreneurial education (EE) and entrepreneurial intention (EI) in the Indian context, which the authors believe is a novel approach to this research stream. The authors also use career preparedness as a control variable to examine this relationship.

Design/methodology/approach
Data were collected from 368 undergraduate students across four Indian universities (one exclusively for female students) through a standard structured questionnaire. Additionally, rather than examining, EI has been treated as a monolithic construct; however, the authors conceptualize it as comprising three different dimensions that include grand vision and risk-taking ability; opportunity exploitation; and ability to persevere. An additional analysis was conducted for the students who reported higher scores for “being well prepared for their careers” through their institutes’ academic programs and communities of entrepreneurs. The authors also interviewed some entrepreneurship instructors, who confirmed the present findings through their observations.

Findings
The findings indicate that, essentially, there is a positive relationship between EE and EI. The authors find that male students scored higher for the first two dimensions of EI but not the third. Additionally, the authors used career preparedness as a control variable for additional analysis. The authors observed that students with higher “career preparedness” reported a positive relationship between EE and EI, independent of gender, for all three dimensions of EI. Thus, it may be assumed that if a community of entrepreneurs needs to be developed in India, a focus on career preparedness is critical.

Research limitations/implications
First, given that the present survey reflected a single moment in linking EE to EI (which may be considered a limitation of the study), future researchers might focus on a longitudinal approach. Second, all the respondents are attending urban universities (and, as such, very likely belong to the upper middle class of Indian society). The financial divide between urban and rural India is well known; as such, the results might be different if the sample was drawn from rural and poor India.

Originality/value
The salience/value of this study lies in the conceptualization of EI comprising three sub-constructs to understand the impact of formal EE (with three sub-constructs) on EI. The focus on career preparedness for a female student is a new direction of inquiry with respect to entrepreneurial intention.
Can regulations prevent financial crises? Uses of the past in the evolution of regulatory reforms in Sweden
Authors: Malmstrom Rognes Asa , Larsson Mats 
Published: April 2023

Purpose
The purpose of this study is to examine whether regulations can prevent financial crises based on the case of Sweden in the 20th century. The evolution of banking regulation relies heavily on learning across borders as well as responding to recent and remembered crises. Sweden went from being an open economy with a highly protected national banking system with several banking crises under the Classical regime, through the Statist regime with no crises followed by abrupt liberalisation in the 1980s as the country changed to a more market-based regime. This study examines the regulatory responses to crises in each of these periods to assess how, and whether, an often backward-looking regulatory framework can address forward-looking risks.

Design/methodology/approach
This study is a qualitative study using a historical method. The authors use archival material, official publications and statistical data as well as secondary literature to succinctly analyse crises and regulatory responses in different regulatory regimes in the 20th century. The theoretical framework builds on three macro- and microeconomic policy regimes, the Classical, the Statist and the Market regime.

Findings
The authors find that regulations can play a decisive role in alleviating a banking crisis, but the relationship between regulations and economic development is complex, and regulations alone cannot prevent a crisis.

Originality/value
To the best of the authors’ knowledge, this is the first longitudinal study of banking regulations in Sweden and how these change in response to crises with the aim of improving the role of banks in financial intermediation and financial stability. This study contributes to a body of literature on financial crises with a long-term perspective and an assessment of regulations as a policy response.
Who discloses carbon information? The joint role of ownership and factor market distortion
Authors: Chen Yu , Zhu Xiaoning , Xiong Xueli , Zhang Cen , Huang Jiashun 
Published: April 2023

PurposeCorporations, as key contributors of greenhouse gas emissions, have been increasingly scrutinized by governments and stakeholders. Corporations have been asked to disclose their carbon-related information. This study investigates public corporate carbon disclosure, an imperative communication channel between firms.Design/methodology/approachThis study uses generalized estimation equation models with a longitudinal panel data of 311 listed firms in the China A-share stock index from 2010 to 2020. This study collected firm-level data from the Carbon Disclosure Project survey, the China Stock Market and Accounting Research, and the National Economic Research Institute of China. Stata was used as the primary statistic software in empirical analyses.FindingsThis study finds that compared to state-owned enterprises (SOEs), private firms are more willing to disclose carbon information under legitimate environmental pressure, and firms in highly distorted factor-markets are reluctant to disclose carbon information. This study finds that factor-distortion markets further moderate ownership and lead private firms in highly distorted factor-markets to behave like SOEs by significantly reducing their carbon disclosures.Originality/valueThis study intends to contribute to the corporate carbon disclosure literature by adding important institutional determinants to the conversation in the context of China.
Investigating environmental policy stringency in OECD countries: implications for the Arab world
Authors: Taha Sara , Yousri Dina , Richter Christian 
Published: April 2023

PurposeAs the world began to witness an unprecedented rate of environmental destruction, economists and international institutions have been toiling away for decades, making every effort to dissect the dynamics of the relationship between the environment and the economy. Many claims have preached that there is a trade-off between environmental wellbeing and economic prosperity, where economic growth would be hindered by environmental protection. As we continue to neglect nature, will the world be capable of maintaining infinitely growing economies without falling into a deficit of natural resources? The foundation of all forms of economic growth springs from nature. Therefore, this study aims to explore the true impact of environmental protection policies on economic performance, and claims that well-designated environmental policies would only strengthen economies.Design/methodology/approachThis study aims to investigate the impact of environmental protection policies on gross domestic product (GDP) growth utilizing a selected sample of 18 OECD countries. Fixed effects panel regression was conducted for the sample from 1998 to 2015.FindingsFindings suggest that an increase in the environmental protection stringency is associated with an increase in GDP in the long-run. Whereas in the short run, more stringent environmental policies have been shown to have a questionable impact on GDP, brought to light by the mixed results portrayed in the short-run data.Research limitations/implicationsWhile it is true that this study has utilized data from the The Organisation for Economic Co-operation and Development (OECD), the findings could be applicable to countries of the MENA region. This is due to the fact that GDP levels of OECD countries and Middle East and North African (MENA) countries have been converging over the past few decades. The convergence suggests that both regions seem to be following similar trends since the year 1990, with an increasing similarity in trend over the years.Originality/valueThis paper empirically proves that the protection of nature is necessary for the sustenance of long-term economic growth. This study also provides an approximate time range of when the economic gains of environmental protection would be realized, specifically in the beginning of a green growth transition. This makes the study findings accurately relevant to Arab countries, where providing a time range is necessary to alleviate some the uncertainty of policymakers in the MENA region towards environmental policies.