bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microfluidics for Carbonate Rock Improved Oil Recovery: Some Lessons from Fabrication, Operation, and Image Analysis
Authors: Duits Michel H. G. , Le-Anh Duy , Ayirala Subhash C. , Alotaibi Mohammed B. , Gardeniers Han , Yousef Ali A. , Mugele Frieder 
Published: September 2023

Summary
After the successful implementation of lab-on-a-chip technology in chemical and biomedical applications, the field of petroleum engineering is currently developing microfluidics as a platform to complement traditional coreflooding experiments. Potentially, microfluidics can offer a fast, efficient, low-footprint, and low-cost method to screen many variables such as injection brine composition, reservoir temperature, and aging history for their effect on crude oil (CRO) release, calcite dissolution, and CO2 storage at the pore scale. Generally, visualization of the fluid displacements is possible, offering valuable mechanistic information. Besides the well-known glass- and silicon-based chips, microfluidic devices mimicking carbonate rock reservoirs are currently being developed as well. In this paper, we discuss different fabrication approaches for carbonate micromodels and their associated applications. One approach in which a glass micromodel is partially functionalized with calcite nanoparticles is discussed in more detail. Both the published works from several research groups and new experimental data from the authors are used to highlight the current capabilities, limitations, and possible extensions of microfluidics for studying carbonate rock systems. The presented insights and reflections should be very helpful in guiding the future designs of microfluidics and subsequent research studies.
P-Frames generated by operator actions in Banach spaces
Authors: Ahmadi Elaheh , Mohammad Janfada 
Published: September 2023

Abstract
Motivated by recent research in dynamical sampling and frame properties of systems from iterative actions of operators in Hilbert spaces, we give generalizations of such a Hilbert frame to a large class of frames in Banach spaces, the so-called p-frames. Let X be an infinite-dimensional separable Banach space with dual space X∗. The main purpose of this paper is to investigate the p-frames having the form {Tnφ}∞n=0 for some linear operator T : X∗ → X∗ and φ ∈ X∗. Similar to the frames in Hilbert spaces, we give various characterizations of the p-frames having such representation for a bounded operator T. In particular, we prove that any q-Riesz basis for X∗ has the form {Tnφ}∞n=0 for some injective bounded operator T : X∗ → X∗ with closed range.
The Meteoritics Trial: Efficacy of Methotrexate after Remission-Induction with Tocilizumab and Glucocorticoids in Giant Cell Arteritis: Study Protocol for a Randomized, Double-Blind, Placebo-Controlled, Parallel Group Phase II Study
Authors: Kreis Lena , Dejaco Christian , Schmidt Wolfgang Andreas , Németh Robert , Venhoff Nils , Schäfer Valentin Sebastian 
Published: September 2023

Abstract
• Background:
Glucocorticoids (GC) are the standard treatment for giant cell arteritis (GCA), even though they are associated with adverse side effects and high relapse rates. Tocilizumab (TCZ), an interleukin-6 receptor antagonist, has shown promise in sustaining remission and reducing the cumulative GC dosage, but it increases the risk of infections and is expensive. After discontinuation of TCZ, only about half of patients remain in remission. Additionally, only few studies have been conducted looking at remission maintenance, highlighting the need for alternative strategies to maintain remission in GCA. Methotrexate (MTX) has been shown to significantly decrease the risk of relapse in new-onset GCA and is already a proven safe drug in many rheumatologic diseases.
• Methods:
This study aims to evaluate the efficacy and safety of MTX in maintaining remission in patients with GCA who have previously been treated with GC and at least six months with TCZ. We hypothesise that MTX can maintain remission in GCA patients, who have achieved stable remission after treatment with GC and TCZ, and prevent the occurrence of relapses. The study design is a monocentric, randomised, double-blind, placebo-controlled, parallel group phase II trial randomising 40 GCA patients 1:1 into a MTX or placebo arm. Patients will receive 17.5 mg MTX / matching placebo weekly by subcutaneous injection for 12 months, with the possibility of dose reduction if clinically needed. A six-month follow up takes place. The primary endpoint is the time to first relapse in the MTX group versus placebo during the 12-month treatment period. Secondary outcomes include patient- and investigator-reported outcomes and laboratory findings, as well as the prevalence of aortitis, number of vasculitic vessels, and change in intima-media thickness during the study.
• Discussion:
This is the first clinical trial evaluating remission maintenance of GCA with MTX after a previous treatment cycle with TCZ. Following the discontinuation of TCZ in GCA, MTX could be a safe and inexpensive drug.
• Trial registration: ClinicalTrials.gov, NCT05623592. Registered 21.11.2022, https://classic.clinicaltrials.gov/ct2/show/NCT05623592?term=giant+cell+arteriitis&cond=methotrexate&draw=2&rank=1
EU Clinical Trials Register, 2022-501058-12-00
German Clinical Trials Register DRKS00030571
Advancing China's sustainable future: Financial development, carbon emissions, urbanization, and renewable energy production under the Paris Agreement
Authors: Zhang Jinyi , Chen Tianchen 
Published: September 2023

Abstract

The COP26 brought global attention to pressing environmental issues such as carbon emissions, financial development, urbanization, and renewable energy production. This paper employs a nonlinear ARDL model to examine the asymmetric impact of financial development and urbanization on environmental pollution in China from 1970 to 2021. By utilizing the framework of renewable energy within Solow growth model, we assess the effects on environmental quality. The results demonstrate that the financial development and urbanization contribute positively to enhancing renewable energy production that will contribute to controlling emissions level. However, the short-term projections reveal a positive relationship between urbanization, economic growth, and renewable energy production in China. Our findings provide valuable insights for addressing environmental pollution in China and offer precise guidelines for carbon policy. Additionally, we present specific policy recommendations to support the objective of sustainable development.
Enteric parasites and associated factors in cancer patients in Nepal
Authors: Singh Barsha , Dhakal Pitambar , Parajuli Rajendra P 
Published: September 2023

Abstract
Infection with intestinal parasites is widespread worldwide, specially in developing countries. Intestinal parasites are a major cause of diarrhea in both immunocompetent and immunocompromised people, but cancer patients are more prone to infection, which can be fatal. This study aimed to investigate the prevalence and risk factors of intestinal parasitic infections (IPIs) among Cancer patients undergoing chemotherapy at Nepal Cancer Hospital and Research Center (NCHRC) in Nepal with suppressed immunity. One hundred individuals were selected with a convenience sampling strategy. The stool samples were examined by direct wet mount, sedimentation, flotation, and acid-fast methods to determine the prevalence and intensity of IPIs in this population. The overall prevalence of IPIs was 8% (4% protozoan and 4% helminths). Altogether, three species of intestinal parasites were detected. Cryptosporidium (4%) was predominant followed by Trichuris trichiura (2%) and Ancylostoma duodenale (2%). Multivariable regression analysis revealed that “not using soap for handwashing” was significantly associated with the prevalence of overall IPIs. None of the other evaluated risk factors indicated an association with IPIs infection. In this study, the IPIs were attributable to individual hygiene behaviors, but not to nutritional status or socio-demographic characteristics. Yet, significant numbers of males reported anemia and undernutrition in this study population.
Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages
Authors: Chen Haiquan , Zhao Yue , Gao Jian , Wang Jun , Fan Fanfan , Cheng Chao , Qian Danwen , Guo Ran , Zhang Yang , Ye Ting , Augustine Marcellus , Li Hang , Pan Yunjian , Huang Qingyuan , Chen Haiqing , Han Han , Gao Zhendong , Fu Fangqiu , Yan Yueren , Patel Shanila , Vendramin Roberto , Yuan Hui , Zhang Yawei , Xiang Jiaqing , Hu Hong , Sun Yihua , Li Yuan , Litchfield Kevin , Cao Zhiwei 
Published: September 2023

Abstract

Multiple synchronous lung cancers (MSLCs) constitute a unique subtype of lung cancer. To explore the genomic and immune heterogeneity across different pathological stages of MSLCs, we analyzed 16 MSLCs from 8 patients using single-cell RNA-seq, single-cell TCR sequencing, and bulk whole-exome sequencing. Our investigation revealed clonally independent tumors with convergent evolution driven by shared driver mutations. However, tumors from the same individual exhibited minimal shared mutations, indicating independent origins. During the transition from pre-invasive to invasive adenocarcinoma, we observed a shift in T cell phenotypes characterized by increased Tregs and exhausted CD8 + T cells, accompanied by diminished cytotoxicity. Additionally, invasive adenocarcinomas exhibited greater neoantigen abundance and a more diverse TCR repertoire, indicating heightened heterogeneity. In summary, despite having a common genetic background and environmental exposure, our study emphasizes the individuality of MSLCs at different stages, highlighting their unique genomic and immune characteristics.
Knowledge about Glaucoma among Adults in Africa: A Systematic Review and Meta-Analysis
Authors: Yimam Wondwossen , Anbesaw Tamrat , Seid Muhammed , Kumar Prem , Wolie Hawa 
Published: September 2023

Abstract
Background
Africa is one of the continents with a substantial burden of glaucoma, where it is approximately twice as common as it is worldwide. If left untreated, glaucoma can cause blindness and permanent vision loss if it is not addressed promptly. Good knowledge is essential for preventing glaucoma's irreversible blindness and ocular damage. However, no systematic review and meta-analysis has been done to report the pooled percentage of adults in Africa who have good knowledge about glaucoma. Therefore, this systematic review and meta-analysis aimed to estimate the pooled percentage of adults in Africa with a good level of knowledge about glaucoma and the determinant factors influencing it.
Methods
Following the PRISMA guidelines, authors systematically reviewed and meta-analyzed studies that investigated the pooled percentage of good knowledge about glaucoma in Africa from PubMed/MEDLINE, Web of Science, PROQEST (PQDT), CINAHL (EBSCO), Google Scholar, African Journal Online, and WHO HINARI databases. Heterogeneity across studies was evaluated using the I² test statistic and P values. Potential publication bias was assessed using Egger’s test and the funnel plots. Subgroup analysis was performed based on publication year, study location, age of participants, and sample size.
Results
In the present meta-analysis, 2781 articles were initially identified and evaluated. Of these, 8 studies that met the inclusion criteria were included in the final analysis. The pooled percentage of good knowledge about glaucoma among adults in Africa was 25% (95% CI: 16.0%, 35.0%). The pooled estimate of good knowledge among adults in Africa was higher in Ethiopia (39.0%) than Nigeria (15.0%) and good knowledge among adults in Africa was higher among participants 35 years of age or more (50.0%) than 18 years of age or more (17.0%). Being literate and having a history of an eye examination were the main determinants of good knowledge about glaucoma among adults in Africa.
Conclusion
This systematic review and meta-analysis found low good knowledge about glaucoma among adults in Africa, with being literate and having history of eye examination were key main determinant factors. Education campaigns and promotion of eye exams are recommended to improve good knowledge about glaucoma.
Systematic review registration:
PROSPERO CRD42023430723
Autoantibodies against Angiotensin-converting enzyme 2 and immune molecules are associated with COVID-19 disease severity
Authors: Bradley Todd , Geanes Eric , McLennan Rebecca , LeMaster Cas 
Published: September 2023

Abstract
Increased inflammation caused by SARS-CoV-2 infection can lead to severe coronavirus disease 2019 (COVID-19) and long-term disease manifestations referred to as post-acute sequalae of COVID (PASC). The mechanisms of this variable long-term immune activation are poorly defined. Autoantibodies targeting immune factors such as cytokines, as well as the viral host cell receptor, angiotensin-converting enzyme 2 (ACE2), have been observed after SARS-CoV-2 infection. Autoantibodies to immune factors and ACE2 could interfere with normal immune regulation and lead to increased inflammation, severe COVID-19, and long-term complications. Here, we deeply profiled the features of ACE2, cytokine, and chemokine autoantibodies in samples from patients recovering from severe COVID-19. We identified epitopes in the catalytic domain of ACE2 targeted by these antibodies, that could inhibit ACE2 function. Levels of autoantibodies targeting ACE2 and other immune factors could serve as determinants of COVID-19 disease severity, and represent a natural immunoregulatory mechanism in response to viral infection.
Poor postpartum hemorrhage morbidity and menstrual recovery in placenta accreta spectrum patients with placenta previa
Authors: Chen Yihong , Zheng Shan , Chen Shaozhan , Lin Rong , Chen Lihui , Zhang Yi , Huang Xuemei , Hu Jifen , Wei Juanbing 
Published: September 2023

Abstract
Introduction: Placenta accreta spectrum is a complex and dangerous disease during pregnancy. We assessed the risk factors for postpartum hemorrhage and menstrual recovery in palcenta accreta spectrum patients with placenta previa.
Methods: Patients were enrolled between January 2010 and January 2020. Logistic regression analysis was performed to assess the risk factors. The area under the receiver operating characteristic curve of sensitivity and specificity was used to predict the risk of menstrual recovery and postpartum hemorrhage.
Results: Overall, 248 patients with placenta accreta spectrum were enrolled. Multiple logistic regression analysis showed that placental grading after delivery (p<0.001), placenta previa with implantation (p<0.001), postpartum D-dimer level (p=0.004), and albumin level (p=0.037) were independent risk factors for postpartum hemorrhage. Placental grading after delivery (p<0.001), blood transfusion (p=0.010), placenta previa with implantation (p=0.002), postpartum hemorrhage (p=0.013), and diastolic pressure (p=0.035) were independent risk factors for menstrual recovery after one year. The area under the receiver operating characteristic curve of placenta previa with implantation plus postpartum hemorrhage for predicting menstrual recovery after 1 year was 0.783 (95% confidence interval [CI]: 0.719-0.847, p<0.001), and that of placenta previa with implantation plus D-dimer was 0.717 (95% CI: 0.653-0.780, p<0.001) for predicting postpartum hemorrhage.
Discussion: Postpartum hemorrhage morbidity and menstrual recovery are poor in placenta accreta spectrum patients with placenta previa.
Optimization of the pick and place sequence of a bimanual collaborative robot in an industrial production line
Authors: Méndez Jorge Borrell , Perez-Vidal Carlos , Segura Jose Vicente 
Published: September 2023

Abstract

This paper focuses on optimizing pick-and-place tasks performed by a dual-arm collaborative robot in a specific shoe manufacturing industry environment. The robot must identify the parts of a shoe placed on a tray, pick them up, and place them in a shoe mold for further processing. The shoe parts arrive on the tray in random positions and angles and can be picked up in a different order. Optimizing these tasks could increase the assembly speed of each unit and improve shoe production. To achieve this goal, a mathematical model based on binary integer linear programming (BILP) has been developed. This model determines the optimal sequence for picking and placing the shoe parts in the mold, thus minimizing the time required for picking and decision-making. The effectiveness of this approach has been tested using two 3-piece unit shoe models: one for training and another for validation. These models encompass a total of 500 trays. An analysis of the results reveals that BILP offers advantages for task motion planning in complex environments with multiple trajectories and the potential for collisions between arms. The model's generalizability to shoes with n assembly parts further confirms its robustness for various part counts.
Pre-clinical testing of two serologically distinct chimpanzee-origin adenovirus vectors expressing spike of SARS-CoV-2
Authors: Chekaoui Arezki , Novikov Mikhail , Xiang Zhiquan , Hasanpourghadi Mohadeseh , Ambrose Robert , Chekaoui Arezki , Newman Dakota , Giles-Davis Wynetta , Zhou Xiang Yang 
Published: September 2023

AbstractTwo serologically distinct chimpanzee-origin, replication-defective adenovirus (AdC) vectors expressing the spike (S) protein of an early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolate were generated and tested for induction of antibodies in mice. Both vectors induced S protein-specific antibodies including neutralizing antibodies. Levels of antibodies increased after a boost. The effectiveness of the boost depended on vector dose, timing between the two immunizations and the use of homologous versus heterologous AdC vectors. Virus neutralizing antibodies (VNAs) showed only a slight loss of reactivity against variants, which may reflect the pronounced responses against the more conserved S2 subunit of the S protein. Expression of two different S proteins by the AdC vectors used for the prime and the boost did not selectively increase responses against the variants. A vector expressing the fusion peptide of the S2 protein induced highly cross-reactive VNA responses, which, nevertheless, were not sustained.
Modified Technique of Hepatojejunostomy for Biliary Tract Reconstruction After Resection of Perihilar Tumors: A case series
Authors: Kuang Yi , Ji Ran , Yuan Tao , Liu Menggang 
Published: September 2023

Abstract
Backgrounds:Radical resection is the most effective treatment for hilar cholangiocarcinoma. Biliary tract reconstruction after resection is one of the key steps in this surgery. Mucosa-to-mucosa cholangiojejunostomy is traditionally performed, in which the bile ducts at the resection margin are separately anastomosed to the jejunum. However, this approach is associated with long operative time and high risk of postoperative complications. The present study presents a modified technique of hepatojejunostomy, and its outcomes.
Methods:The data of patients who underwent hepatojejunostomy using the modified technique at the Department of Hepatobiliary Surgery, Daping Hospital, Army Medical University, Chongqing, China, from January 2016 to December 2021, were retrospectively analyzed.
Results:A total of 13 patients with perihilar tumors underwent R0 resection and bilioenteric reconstruction using the modified hepatojejunostomy technique during the study period. During the operation, the alignment of the bile duct stumps was improved, the posterior wall of the anastomosis was reinforced, internal stents were placed in the smaller bile ducts, external stents were placed in the larger bile ducts, and hepatojejunostomy was performed using 4-0 prolene. No serious postoperative complications, such as death or bile leakage, occurred during the hospitalization. Furthermore, there were no cases of biliary stricture or cholangitis after the six-month follow-up period.
Conclusion:The modified hepatojejunostomy technique is a safe and effective technique of biliary reconstruction after the resection of perihilar tumors. This can be easily performed for difficult cases with multiple bile ducts that require reconstruction after resection.
Risk factors of temporomandibular joint anterior disc displacement associated with dental malocclusion: a cross-sectional study
Authors: Qu Guanlin , Bu Lingtong , Shen Pei , Xie Qianyang , Ge Jing , Luo Yi , Ma Zhigui , Yang Chi 
Published: September 2023

Abstract
Objective
This study aimed to investigate the risk factors associated with temporomandibular joint (TMJ) anterior disc displacement (ADD) in relation to dental malocclusion.
Methods
In this cross-sectional study, a clinical examination was conducted on patients aged 11–35 years who visited the TMJ and Orthodontic Clinic at a hospital. Magnetic resonance imaging (MRI) of the TMJ was performed to diagnose both ADD and condylar resorption (CR). Occlusal measurements were obtained and analyzed using 3D scanning models.
Results
A total of 552 patients underwent TMJ MRI examination and dental occlusion scanning. The presence of mandibular midline shift > 2 mm and posterior crossbite were found to be associated with unilateral ADD (OR > 1, p < 0.05). Additionally, apart from these malocclusions, anterior open bite > 3 mm showed a strong correlation with unilateral ADD accompanied by CR (OR > 1, p < 0.05). Furthermore, overbite > 4 mm and posterior crossbite were associated with bilateral ADD (OR > 1, p < 0.05). In addition to these malocclusions, Angle Class II malocclusion, overjet > 5 mm, and anterior open bite > 3 mm were strongly correlated with bilateral ADD accompanied by CR (OR > 1, p < 0.05).
Conclusions
In conclusion, our study highlights the significance of occlusal characteristics in relation to TMJ health. Specific malocclusions, such as mandibular midline shift > 2 mm, posterior crossbite, and overbite > 4 mm appear to be associated with the presence of TMJ ADD. Angle Class II malocclusion, anterior open bite and overjet > 5 mm seem to be associated with progression of ADD. These findings emphasize the crucial importance of early detection and management of malocclusions to prevent or minimize the development of TMJ ADD and associated complications.