bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination of Intravenous and Intra‐Articular Application of Tranexamic Acid and Epsilon‐Aminocaproic Acid in Primary Total Knee Arthroplasty: A Prospective Randomized Controlled Trial
Authors: Zheng Che , Ma Jun , Xu Jiawen , Si Haibo , Liu Yuan , Li Mingyang , Shen Bin 
Published: December 2022

ObjectiveThere were limited randomized controlled trials (RCTs) of epsilon‐aminocaproic acid (EACA) versus tranexamic acid (TXA) in total knee arthroplasty (TKA). The aim of the study was to compare the efficacy and safety of TXA and EACA in the combination of intravenous (IV) and intra‐articular (IA) administration on reducing blood loss in patients following primary TKA.MethodsFrom January 2020 to January 2021, a total of 181 patients undergoing a primary unilateral TKA were enrolled in this prospective randomized controlled trial. Patients in the TXA group (n = 90) received 20 mg/kg of intravenous TXA preoperatively, 1 g of intra‐articular TXA intraoperatively, and three doses of 20 mg/kg intravenous TXA at 0, 3, 6 h postoperatively. Patients in the EACA group (n = 91) received 120 mg/kg of intravenous EACA preoperatively, 2 g of intra‐articular EACA intraoperatively, and three doses of 40 mg/kg intravenous EACA at 0, 3, 6 h postoperatively. The primary outcomes were total blood loss (TBL), transfusion rates and drop of hemoglobin (HB) level. The secondary outcomes included postoperative hospital stays and postoperative complications. The chi‐square tests and Fisher's exact tests were utilized to compare categorical variables, while the independent‐samples t‐tests and Mann–Whitney tests were used to compare continuous variables.ResultsThe patients who received TXA averaged less TBL than the patients who received EACA (831.83 ml vs 1065.49 ml, P = 0.015), and HB drop in TXA group was generally less than that of EACA group on postoperative day 1 and 3 (20.84 ± 9.48 g/L vs 24.99 ± 9.40 g/L, P = 0.004; 31.28 ± 11.19 vs 35.46 ± 12.26 g/L, P = 0.047). The length of postoperative stays in EACA group was 3.66 ± 0.81 day, which is longer than 2.62 ± 0.68 day in TXA group (P < 0.001). No transfusions were required in either group. The risk of nausea and vomiting in TXA group was significantly higher than that in EACA group (11/90 vs 0/91, P < 0.01).ConclusionAlthough the TBL and HB drop were slightly greater in EACA group, these results were not clinically important, given that no transfusions were required. EACA could be an alternative to TXA, especially for patients with severe nausea and vomiting after using TXA postoperatively. Further studies are needed to adjust dosage of EACA to make better comparison of the two drugs.
Recognition of glycoside hydrolase 12 proteins by the immune receptor RXEG1 confers Fusarium head blight resistance in wheat
Authors: Wang Zongkuan , Yang Bo , Zheng Wenyue , Wang Lei , Cai Xingxing , Yang Jie , Song Rongrong , Yang Sen , Wang Yuyin , Xiao Jin , Liu Huiquan , Wang Yan , Wang Xiue , Wang Yuanchao 
Published: December 2022

SummaryFusarium head blight (FHB), caused by Fusarium graminearum, is a devastating disease in wheat (Triticum aestivum) that results in substantial yield losses and mycotoxin contamination. Reliable genetic resources for FHB resistance in wheat are lacking. In this study, we characterized glycoside hydrolase 12 (GH12) family proteins secreted by F. graminearum. We established that two GH12 proteins, Fg05851 and Fg11037, have functionally redundant roles in F. graminearum colonization of wheat. Furthermore, we determined that the GH12 proteins Fg05851 and Fg11037 are recognized by the leucine‐rich‐repeat receptor‐like protein RXEG1 in the dicot Nicotiana benthamiana. Heterologous expression of RXEG1 conferred wheat responsiveness to Fg05851 and Fg11037, enhanced wheat resistance to F. graminearum and reduced levels of the mycotoxin deoxynivalenol in wheat grains in an Fg05851/Fg11037‐dependent manner. In the RXEG1 transgenic lines, genes related to pattern‐triggered plant immunity, salicylic acid, jasmonic acid, and anti‐oxidative homeostasis signalling pathways were upregulated during F. graminearum infection. However, the expression of these genes was not significantly changed during infection by the deletion mutant ΔFg05851/Fg11037, suggesting that the recognition of Fg05851/Fg11037 by RXEG1 triggered plant resistance against FHB. Moreover, introducing RXEG1 into three other different wheat cultivars via crossing also conferred resistance to F. graminearum. Expression of RXEG1 did not have obvious deleterious effects on plant growth and development in wheat. Our study reveals that N. benthamiana RXEG1 remains effective when transferred into wheat, a monocot, which in turn suggests that engineering wheat with interfamily plant immune receptor transgenes is a viable strategy for increasing resistance to FHB.
When leaders heed the lessons of mistakes: Linking leaders’ recall of learning from mistakes to expressed humility
Authors: Hu Jia (Jasmine) , Zhang Shuxia , Lount Robert B. , Tepper Bennett J. 
Published: December 2022

AbstractMaking mistakes is an inevitable part of leadership, but little is known about how and when leaders benefit from reflecting on their missteps. In this paper, we propose that mistakes, when reflected upon, have the potential to increase a leader's expressed humility. We detail how having leaders recall past mistakes can help them formulate plans for learning and encourage them to express humility. We also argue that this positive relationship is strengthened when leaders have a promotion focus. We detail downstream benefits, as increased levels of leaders’ expressed humility are expected to increase their teams’ improvement‐oriented behaviors and, subsequently, team performance. Across multiple studies and using varied methods (i.e., scenario‐based experiments with 955 managerial leaders, a laboratory experiment with 210 student leaders and team members, and a daily field experiment with 85 managers), we empirically test the proposed relationships. Our studies contribute to the literature by identifying leaders’ recall of learning from mistakes as an important intervention to elicit their expressed humility.
From consistency to flexibility: Handling spatial information schema thanks to a middleware in a 3D city modeling context
Authors: Nys Gilles‐Antoine , Billen Roland 
Published: December 2022

AbstractTwinning elements of reality gains a growing interest in support of decision‐making, learning, and simulations: a single and shared model should provide a unique integrative basis for managing assets of any replica of the real world. From a technical viewpoint, sharing and opening information requires both an exchange format and a high degree of freedom and flexibility. It should allow an important number of users to manage this information, to modify it, etc. Storing and manipulating spatial information concerning the urban built context currently focuses on ensuring consistency thanks to relational databases and predefined schemas. Following a paradigm shift from a relational database to a NoSQL database, a schema validation middleware is proposed to improve the flexibility of storage by conceding a share of its consistency. The flexibility improvements thus provide users a common basis that is able to evolve all along the lifecycle of their models and applications as required for twinning things. It allows users and their applications to take advantage of new storage features such as common: versioning, partitioning, prioritization, applications profiles, etc. The middleware and their new capabilities are illustrated thanks to the CityJSON encoding and its simplified schema for a document‐oriented database.
Evaluation of Physical Activity Indicators for French Children and Adolescents With Disabilities: National Para Report Card and SWOT Analysis
Authors: Aubert Salomé , Verdot Charlotte , Thöni Gilles , Vanhelst Jérémy 
Published: December 2022

The objectives of this work were (a) to adopt the Active Healthy Kids Global Alliance Report Card methodology to evaluate the state of physical activity (PA) for French children and adolescents with disabilities (CAWD) and (b) to identify the strengths, weaknesses, opportunities, and threats (SWOT) perceived by French PA experts for promoting PA among CAWD. The harmonized Active Healthy Kids Global Alliance Report Card development process was used to assign a grade to the 10 common PA indicators. SWOT templates were completed by PA experts and then collapsed in a summary figure. Despite increasing efforts to provide active opportunities to CAWD, concerning low grades were assigned to behavioral indicators. SWOT analysis provided important insights for the promotion of PA in CAWD. This work highlighted the need for the inclusion of CAWD in a comprehensive national PA surveillance system and for more efficient strategies promoting PA specifically targeting CAWD in France.
Talent Identification in Youth Basketball: Talent Scouts’ Perceptions of the Key Attributes for Athlete Development
Authors: Larkin Paul , Sanford Madison , Talpey Scott , Gorman Adam D. , Reeves Matthew J. 
Published: December 2022

The objective of this study is to understand the attributes youth coaches and talent scouts perceive as important when identifying skilled youth basketball players. Youth coaches and talent scouts (n = 40) from Australia, Canada, the United Kingdom, and United States with an average of 14.09 (±9.77) years of experience completed an online questionnaire. The questionnaire asked participants to rank and justify attributes for identifying potentially talented youth basketball players according to their perceived importance. In addition, five youth coaches and talent scouts completed a semistructured interview that elaborated on how they identify these attributes in national-level youth players. Results from the questionnaire indicate a hierarchy of attributes coaches/scouts perceive as important for youth basketball performance, including tactical (i.e., decision-making ability), technical (i.e., layup, shooting in the paint, jump shot, rebounding), and psychological attributes (i.e., composure, concentration, adaptability). In addition, the results from the interviews provided more detailed justification for the importance of these attributes within the talent identification process. It is believed talent scouts apply a holistic multidisciplinary approach to talent identification, with the current findings potentially providing evidence to suggest coaches/scouts consider a wide range of tactical, technical, psychological, and physical attributes when identifying youth players.
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas
Authors: Cervia Lisa D. , Shibue Tsukasa , Borah Ashir A. , Gaeta Benjamin , He Linh , Leung Lisa , Li Naomi , Moyer Sydney M. , Shim Brian H. , Dumont Nancy , Gonzalez Alfredo , Bick Nolan R. , Kazachkova Mariya , Dempster Joshua M. , Krill-Burger John Michael , Piccioni Federica , Udeshi Namrata D. , Olive Meagan E. , Carr Steven A. , Root David E. , McFarland James M. , Vazquez Francisca , Hahn William C. 
Published: December 2022

AbstractSystematic identification of signaling pathways required for the fitness of cancer cells will facilitate the development of new cancer therapies. We used gene essentiality measurements in 1,086 cancer cell lines to identify selective coessentiality modules and found that a ubiquitin ligase complex composed of UBA6, BIRC6, KCMF1, and UBR4 is required for the survival of a subset of epithelial tumors that exhibit a high degree of aneuploidy. Suppressing BIRC6 in cell lines that are dependent on this complex led to a substantial reduction in cell fitness in vitro and potent tumor regression in vivo. Mechanistically, BIRC6 suppression resulted in selective activation of the integrated stress response (ISR) by stabilization of the heme-regulated inhibitor, a direct ubiquitination target of the UBA6/BIRC6/KCMF1/UBR4 complex. These observations uncover a novel ubiquitination cascade that regulates ISR and highlight the potential of ISR activation as a new therapeutic strategy.Significance:We describe the identification of a heretofore unrecognized ubiquitin ligase complex that prevents the aberrant activation of the ISR in a subset of cancer cells. This provides a novel insight on the regulation of ISR and exposes a therapeutic opportunity to selectively eliminate these cancer cells.See related commentary Leli and Koumenis, p. 535.This article is highlighted in the In This Issue feature, p. 517
Hydrogen Sulfide Modulates Endothelial–Mesenchymal Transition in Heart Failure
Authors: Li Zhen , Xia Huijing , Sharp Thomas E. , LaPenna Kyle B. , Katsouda Antonia , Elrod John W. , Pfeilschifter Josef , Beck Karl-Friedrich , Xu Shi , Xian Ming , Goodchild Traci T. , Papapetropoulos Andreas , Lefer David J. 
Published: December 2022

Background:
Hydrogen sulfide is a critical endogenous signaling molecule that exerts protective effects in the setting of heart failure. Cystathionine γ-lyase (CSE), 1 of 3 hydrogen-sulfide–producing enzyme, is predominantly localized in the vascular endothelium. The interaction between the endothelial CSE–hydrogen sulfide axis and endothelial-mesenchymal transition, an important pathological process contributing to the formation of fibrosis, has yet to be investigated.

Methods:
Endothelial-cell–specific CSE knockout and Endothelial cell-CSE overexpressing mice were subjected to transverse aortic constriction to induce heart failure with reduced ejection fraction. Cardiac function, vascular reactivity, and treadmill exercise capacity were measured to determine the severity of heart failure. Histological and gene expression analyses were performed to investigate changes in cardiac fibrosis and the activation of endothelial–mesenchymal transition.

Results:
Endothelial-cell–specific CSE knockout mice exhibited increased endothelial–mesenchymal transition and reduced nitric oxide bioavailability in the myocardium, which was associated with increased cardiac fibrosis, impaired cardiac and vascular function, and worsened exercise performance. In contrast, genetic overexpression of CSE in endothelial cells led to increased myocardial nitric oxide, decreased endothelial–mesenchymal transition and cardiac fibrosis, preserved cardiac and endothelial function, and improved exercise capacity.

Conclusions:
Our data demonstrate that endothelial CSE modulates endothelial–mesenchymal transition and ameliorate the severity of pressure-overload–induced heart failure, in part, through nitric oxide-related mechanisms. These data further suggest that endothelium-derived hydrogen sulfide is a potential therapeutic for the treatment of heart failure with reduced ejection fraction.
The Epistemological Relevance of Conceptual Change
Authors: Liptow Jasper 
Published: December 2022

Abstract
The purpose of this article is to show that the customary understanding of epistemic progress as a kind of belief change is incomplete and that conceptual change has to be acknowledged as a crucial driving force in epistemic progress. The author’s argument for the epistemological relevance of conceptual change proceeds as follows. First, he develops an account of conceptual change that clearly distinguishes conceptual change from belief change. He then takes a closer look at two kinds of conceptual change that are of special interest from an epistemological point of view. He calls them “disclosing” conceptual change and “revisionary” conceptual change. He then shows that the idea of epistemic value that demarcates the realm of epistemological inquiry applies to concepts and conceptual change.
“Dann ich auch der gůten Gesellen einer bin die man die freyen Knaben nennet.”
Authors: Wirth Luca Lil 
Published: December 2022

Abstract
This article reinterprets the alleged self-portrayal of the early modern author Michael Lindener (* between 1520 and 1530, † 1562) in his Schwanksammlung Katzipori (1558) by revealing its fictional character. Scholars read the text as the autobiography of a morally despicable bon vivant. Against this line of interpretation, this article proposes a radical distinction between author and narrator, showing how Lindener ironically undermines the well-established canon of poetical rules of his time while portraying himself as the mischievous libertine Compan.
Desanka Maksimović’s Engaged Medical Novel “The Open Window” (1954): Tuberculosis as a Social(ist) Issue
Authors: Barać Stanislava 
Published: December 2022

Desanka Maksimović’s Engaged Medical Novel The Open Window (1954): Tuberculosis as a Social(ist) Issue The Open Window (1954) is a novel written by the critically acclaimed and renowned poet Desanka Maksimović and continues in the same vein as her pre-war socially engaged short stories. It shows a possible new form of engagement not only in the author’s own work but also in Yugoslav literature in general. The initial hypothesis of this paper is that Maksimović – by intentionally choosing the genre of thethesis novel, and by shaping (consciously or unconsciously) the genre ofder Arztroman or the medical novel – takes part in a tradition of popular genres which hybridizes enlightenment with entertainment. The aims of this paper are a) to define the given genres and place The Open Window within the traditions mentioned above; b) to define and analyze the novel’s representation of tuberculosis; c) to explain how the author placed the subject of this contagious disease and its epidemic spread throughout the Kingdom of Yugoslavia into the frame of the debate between conservative and emancipatory social movements.Zaangażowana powieść medyczna Desanki Maksimović Otwarte okno (1954). Gruźlica jako problem socjal(istycz)nyOtwarte okno (1954) to powieść cenionej przez krytykę poetki Desanki Maksimović, która wpisuje się w nurt pisanych przez nią przed wojną zaangażowanych społecznie opowiadań. Powieść wyznacza nie tylko nowy kierunek zaangażowania autorki w obrębie jej własnej twórczości, lecz także w literaturze jugosłowiańskiej w ogóle. Wstępna hipoteza artykułu jest taka, że Maksimović – wybierając gatunek powieści z tezą i (świadomie lub nie) kształtując gatunek der Arztroman czy też powieści medycznej – wpisuje się w tradycję gatunków popularnych, które łączą naukę z rozrywką. Celem artykułu jest: a) zdefiniowanie danych gatunków i umiejscowienie Otwartego okna w ramach wymienionych tradycji; b) zdefiniowanie i przeanalizowanie obrazu gruźlicy w powieści; c) wyjaśnienie, w jaki sposób autorka wpisała temat tej zakaźnej choroby i jej epidemii w Królestwie Jugosławii w ramy debaty między konserwatywnymi i emancypacyjnymi ruchami społecznymi.
The Dead Female Body and Necropolitics. The Topos of a Walled-up Woman in Bulgarian Modernist Plays
Authors: Szwat-Gyłybowa Grażyna 
Published: December 2022

The Dead Female Body and Necropolitics. The Topos of a Walled-up Woman in Bulgarian Modernist PlaysIn Bulgarian folk tradition, the topos of a woman entombed in a wall is a remnant of a dead myth that is still commemorated in the canon of that culture. In the 19th and 20th centuries, it became the subject of creative recycling in literature and visual arts. The article presents the results of my research on the topos of a walled-up woman in four plays written in the first four decades of the 20th century by Petko Todorov (Зидари), Anton Strashimirov (На безкръстните гробове), Ana Karima (Яниният извор), and Stilyan Chilingirov (Мост на река Струма). The analysis focuses on the issue of the protagonists assigning meaning (determined by cultural gender) to women’s remains “acquired” through the ritual of immurement. It also discusses the ways in which authors employed this “remnant” of national/folk archaic material, which continued to raise moral concern throughout the 20th century and in the 21st century may prove an interesting topic for post-humanist reflection.Martwe kobiece ciało i nekropolityka. Topos wmurowanej kobiety w bułgarskich sztukach modernistycznychW bułgarskiej tradycji ludowej topos wmurowanej kobiety jest pozostałością martwego mitu, który nadal jest upamiętniany w kanonie tej kultury. W XIX i XX wieku stał się on przedmiotem twórczego recyklingu w literaturze i sztukach wizualnych. Artykuł prezentuje wyniki moich badań nad toposem wmurowanej kobiety w czterech sztukach napisanych w pierwszych czterech dekadach XX wieku przez Petko Todorova (Зидари), Antona Strashimirowa (На безкръстните гробове), Any Karimy (Яниният извор) oraz Stilyana Chilingirova (Мост на река Струма). W centrum uwagi stawiam kwestię zdeterminowanego przez płeć kulturową znaczenia, jakie bohaterowie nadają szczątkom kobiecym pozyskanym w wyniku rytuału wmurowania. Omawiam także sposoby, jakimi autorzy wykorzystali tę „pozostałość” narodowej/ludowej archaiczności, która przez cały XX wiek budziła moralny niepokój, a w XXI wieku może okazać się ważnym tematem refleksji post-humanistycznej.
I Think, I Feel, I Decide: The Polish Struggle for Reproductive Rights
Authors: Pupavac Milica 
Published: December 2022

I Think, I Feel, I Decide: The Polish Struggle for Reproductive RightsIn the monograph Gender, Voice, and Violence in Poland: Women’s Protests during the Pandemic, editors Adrianna Zabrzewska and Joshua K. Dubrow have compiled a variety of voices to create a snapshot of a tumultuous time in Polish society, when, in autumn of 2020, the Constitutional Tribunal limited the already heavily restricted abortion access, and unprecedented street protests ensued in the midst of the COVID-19 pandemic. Through the voices of activists, politicians and academics, the editors provide the wider context of the ruling, the protests, and the struggles of the pro-choice and adjacent movements in Poland. Besides documenting these events, the monograph represents an expansive resource for researchers, teachers, and activists alike.Myślę, czuję, decyduję. Polska walka o prawa reprodukcyjneW monografii Gender, Voice, and Violence in Poland: Women’s Protests during the Pandemic redaktorzy Adrianna Zabrzewska i Joshua K. Dubrow zebrali różnorodne głosy, aby stworzyć migawkę burzliwych czasów w społeczeństwie polskim, kiedy to wskutek radykalnego ograniczenia dostępu do aborcji przez Trybunał Konstytucyjny jesienią 2020 roku w warunkach pandemii COVID-19 doszło do niespotykanych dotąd protestów społecznych. Za pośrednictwem głosów aktywistów, polityków i naukowców redaktorzy przedstawiają szerszy kontekst władzy, protestów i walk ruchów pro-choice i podobnych w Polsce. Monografia nie tylko dokumentuje same wydarzenia, lecz stanowi także bogate źródło informacji zarówno dla badaczy, nauczycieli, jak i aktywistów.