bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unsaturated or saturated dietary fat-mediated steatosis impairs hepatic regeneration following partial hepatectomy in mice
Authors: Islam S. M. Touhidul , Palanisamy Arun P. , Chedister Gabriel R. , Schmidt Michael G. , Lewin David N. B. , Chavin Kenneth D. 
Published: May 2023

BackgroundPartial hepatectomy is a preferred treatment option for many patients with hepatocellular carcinoma however, pre-existing pathological abnormalities originating from hepatic steatosis can alter the decision to perform surgery or postoperative outcomes as a consequence of the impact steatosis has on liver regeneration.AimThe aim of this study was to investigate the role of a saturated or unsaturated high fat diet-mediated steatosis on liver regeneration following partial hepatectomy.MethodsMice were fed a low-fat control diet (CD, 13% fat), lard-based unsaturated (LD, 60% fat) or milk-based saturated high fat diet (MD, 60% fat) for 16 weeks at which time partial hepatectomy (approx. 70% resection) was performed. At days-2 and 7 post hepatectomy, one hour prior to euthanization, mice were injected with 5-bromo-2’-deoxyuridine in order to monitor hepatic regeneration. Serum was collected and assessed for levels of ALT and AST. Resected and regenerated liver tissue were examined for inflammation-indicative markers employing RT-PCR, Western blots, and histological methods.ResultsMice fed LD or MD exhibited higher NAFLD scores, increased expression of inflammatory cytokines, neutrophil infiltration, macrophage accumulation, increased apoptosis, and elevated levels of serum ALT and AST activities, a decrease in the number of BrdU-incorporated-hepatocytes in the regenerated livers compared to the mice fed CD. Mice fed MD showed significantly lower percent of BrdU-incorporated hepatocytes and a higher trend of inflammation compared to the mice fed LD.ConclusionA diet rich in saturated or unsaturated fat results in NASH with decreased hepatic regeneration however unsaturated fat diet cause lower inflammation and higher regeneration than the saturated fat diet following partial hepatectomy in mice.
Resting heart rate is a population-level biomarker of cardiorespiratory fitness: The Fenland Study
Authors: Gonzales Tomas I. , Jeon Justin Y. , Lindsay Timothy , Westgate Kate , Perez-Pozuelo Ignacio , Hollidge Stefanie , Wijndaele Katrien , Rennie Kirsten , Forouhi Nita , Griffin Simon , Wareham Nick , Brage Soren 
Published: May 2023

Introduction
Few large studies have evaluated the relationship between resting heart rate (RHR) and cardiorespiratory fitness. Here we examine cross-sectional and longitudinal relationships between RHR and fitness, explore factors that influence these relationships, and demonstrate the utility of RHR for remote population monitoring.

Methods
In cross-sectional analyses (The UK Fenland Study: 5,722 women, 5,143 men, aged 29-65y), we measured RHR (beats per min, bpm) while seated, supine, and during sleep. Fitness was estimated as maximal oxygen consumption (ml⋅min-1⋅kg-1) from an exercise test. Associations between RHR and fitness were evaluated while adjusting for age, sex, adiposity, and physical activity. In longitudinal analyses (6,589 participant subsample), we re-assessed RHR and fitness after a median of 6 years and evaluated the association between within-person change in RHR and fitness. During the coronavirus disease-2019 pandemic, we used a smartphone application to remotely and serially measure RHR (1,914 participant subsample, August 2020 to April 2021) and examined differences in RHR dynamics by pre-pandemic fitness level.

Results
Mean RHR while seated, supine, and during sleep was 67, 64, and 57 bpm. Age-adjusted associations (beta coefficients) between RHR and fitness were -0.26, -0.29, and -0.21 ml⋅kg-1⋅beat-1 in women and -0.27, -0.31, and -0.19 ml⋅kg-1⋅beat-1 in men. Adjustment for adiposity and physical activity attenuated the RHR-to-fitness relationship by 10% and 50%, respectively. Longitudinally, a 1-bpm increase in supine RHR was associated with a 0.23 ml⋅min-1⋅kg-1 decrease in fitness. During the pandemic, RHR increased in those with low pre-pandemic fitness but was stable in others.

Conclusions
RHR is a valid population-level biomarker of cardiorespiratory fitness. Physical activity and adiposity attenuate the relationship between RHR and fitness.
Congenital ventricular outflow tract obstructions in Boxer dogs: Results of a 17-year cardiovascular breed screening program in France (3126 dogs)
Authors: Chetboul Valérie , Bernard Pauline , Passavin Peggy , Tissier Renaud 
Published: May 2023

Introduction
Ventricular outflow tract obstructions including aortic (AS) and pulmonic stenosis (PS) are the most common canine congenital heart diseases, with Boxer dogs being predominantly affected. This has led to the French Boxer club adopting a mandatory national control program against AS and PS. The objective of this retrospective study was to analyze the results of 17 years of this cardiovascular breed screening program (2005–2021).

Materials and methods
The records of untreated and non-anesthetized adult Boxer dogs screened between 2005 and 2021 were retrospectively reviewed. All dogs underwent physical examination and standard transthoracic echocardiography with concomitant ECG tracing. All examinations were reviewed by one single board-certified specialist in cardiology.

Results
Out of the 3126 dogs screened during the study period, 3001 dogs (female:male sex ratio = 2.2, median age [IQR] = 1.6 years [1.2–2.1]) were recruited for data analysis. A total of 218 operators were involved in the screening program. For most Boxer dogs (i.e., 93.8% for AS and 94.5% for PS), a single examination was required to obtain a definitive cardiac status, although most operators were non-specialist general practitioners. A left basilar systolic heart murmur was detected in all dogs with AS and PS, but also in 7.4% dogs free of heart diseases. A significantly higher proportion of the latter was detected when operators were board-certified specialists (P<0.001). Lastly, when comparing the start and the end of the breeding program, among dogs diagnosed with AS and PS (n = 364) in a French referral cardiology center, Boxer went from the 1st affected breed by AS to the 3rd, and from the 3rd affected breed by PS to the 6th.

Conclusion
This 17-year screening program has experienced a strong involvement of veterinarians, breeders, and owners throughout France. This may have contributed to reduce AS and PS prevalence in Boxer dogs at the studied referral cardiology center.
Evaluation of microbial and vancomycin treatments in ulcerative colitis in murine models
Authors: Hasan Nihal , Yang Hongyi 
Published: May 2023

Background
Despite the number of available therapies for ulcerative colitis (UC), severe side effects and high cost has limited their clinical application. Thus, finding new alternative strategies with minimal side effects is inevitable. Therefore, this study aimed to compare the effectiveness of different therapeutic approaches in DSS-induced colitis.

Methods
Firstly, we designed oral bio-therapeutic products, Live Bacterial Products (LBP), which include a mixture of fecal bacteria strains isolated from healthy mice and prepared by microencapsulation and freeze-dried techniques. Then we investigated the efficiency of 7 days of freeze-dried FMT, LBP, and vancomycin treatments in DSS-induced colitis. Secondly, we compared the effect of 15 days of microbial therapies (freeze-dried powder of FMT and LBP microcapsules) and seven days of oral vancomycin on the severity of colitis in mice. Furthermore, the levels of IL-1β and TNF-α were measured in serum by ELISA, and the fecal microbiota diversity was analyzed by high-throughput sequencing for all mice groups.

Results
After seven days of treatments, our results indicated that oral vancomycin reduced the severity of DSS-induced colitis in mice, where weight gain and a decrease in IL-1 β and TNF-α levels were observed in the vancomycin group compared with other treatment groups. While after two weeks of treatment, the LBP microcapsules were able to reduce the severity of colitis. And at the end of the treatment period, weight gain and a decrease in the DAI scores and the levels of IL-1β and TNF-α were noted in the LBP treatment group compared to other treatment groups. By high-throughput sequencing of the 16S rRNA gene, our results showed that while the microcapsules LBP treatment increased the fecal microbial diversity, after vancomycin therapy, most of the fecal microbiota genera and operational taxonomic units (OTUs) were depleted.

Conclusion
Our results concluded that treatment duration and preparation methods affect the microbial therapies’ efficiency in UC. Furthermore, this study highlighted the negative consequences of oral vancomycin administration on gut health that should be known before using this medication.
Psychological burden of achalasia: Patients’ screening rates of depression and anxiety and sex differences
Authors: Hanschmidt Franz , Treml Julia , Deller Julia , Kreuser Nicole , Gockel Ines , Kersting Anette 
Published: May 2023

Objective
Achalasia is associated with reduced quality of life in affected patients but research regarding the psychological burden of achalasia in terms of depression and anxiety is scarce. The current study therefore aims to investigate rates of depression and anxiety in patients with achalasia in relation to prevalence rates in the general population and to examine the extent to which achalasia-related characteristics (time since diagnosis, symptom load, achalasia-related quality of life, treatment history) predict symptoms of depression and anxiety.

Methods
Using validated screening instruments, rates of depression and anxiety were assessed in a cross-sectional survey of a sample of 993 patients with achalasia and compared to population controls stratified by age and sex. Associations between depression and anxiety and achalasia-related factors were explored using linear regression.

Results
Compared to population controls, screening rates of female patients with achalasia were between 3.04 (p = .004) and 7.87 (p < .001) times higher for depression and 3.10 (p < .001) times higher for anxiety, respectively. No significant differences were found for male patients with achalasia. Both achalasia-related quality of life and symptom load were independently related to impaired mental health.

Conclusion
Women appear to be specifically affected by the psychological burden of achalasia, pointing to sex-specific or gendered experiences of the disease. In addition to symptom reduction, psychological support may prove beneficial for improving the well-being of patients with achalasia.
Analysis of error distribution in catalyst-adsorbate binding energies generated by GNN
Authors: Lee Loch Kean , Yeo Hong , Lin Zhuoyi , Senthilnath J , Zhou Bangjian , Yoon Ji Wei 
Published: May 2023

Scalable methods of storing renewable energy to reduce climate change require high- performance catalysts that can be discovered using Artificial Intelligence (AI), prompting data scientists to train models. In the OC20 dataset (IS2RE), the Graphormer model, a type of Graph Neural Network (GNN), performed the best. We hope to find trends in the error distribution of catalyst-adsorbate binding energies to explain and make improvements.
GNNs are based on Graph Theory, which makes them optimised for certain data structures. In the context of molecules, a graph can be used to represent the atomic and molecular structure of a compound through its edges and nodes. By using a GNN, it is possible to effectively capture the intricate relationships and dependencies between the atoms and bonds in a molecule. This is important for predicting and understanding the properties and behaviour of the molecule.
With Python and Jupyter Notebook, we had many cutting-edge packages and libraries at our disposal; some included are matplotlib, pandas, and Atomic Simulation Environment (ASE). Through the data exploration, wrangling, and analysis, several insights were gleaned.
Smaller unit cells tended to have larger errors. Across the period, there are local minima of errors in Group 10. Chlorine, perhaps because it is the only halogen, had an abnormally large error. Adsorbates containing Nitrogen had greater errors, as opposed to ones that are grouped as C1, C2 or O/H only.
Religious Education in the Mitigation Space: The Significance of the Muhammadiyah Enlightenment Movement for West Sulawesi Earthquake Survivors
Authors: Muhammad Alifuddin  , Suarni  , Alhamuddin Alhamuddin , Ahmad Fanani  
Published: May 2023

Purpose – This study aims to describe analytically the active religious education carried out by Muhammadiyah elements for earthquake survivors in Ahu, West Sulawesi. The research data were obtained through participatory observation, in-depth interviews, and document review.
Design/methods/approach – All data obtained were analyzed using Miles and Huberman’s paradigm combined with Von Eckarberg’s hermeneutic phenomenological analysis model.
Findings – The findings and discussion of this research conclude as follows; (1)The enlightenment movement in the field of religious education for survivors in Ahu Village is an integral part of the disaster mitigation program by Muhammadiyah. MDMC volunteers implemented the program for early childhood, kindergarten, and primary education, as well as for groups of survivors from among adults. The religious education program is non-formal, and its implementation uses a contextual learning approach. (2) The religious education program for the survivors is significant, not only because of the process of transferring knowledge but also the process of mental and spiritual enlightenment for the survivors. This process enables the survivors to be more assertive and patient and can respond positively to the reality of the disaster that befell them. (3) Conceptually, the enlightenment movement through active religious education carried out by MDMC can be categorized as a disaster risk reduction effort that is non-physical and is part of the concept of disaster mitigation.
Research implications/limitations – Thus, this research is expected to have implications for efforts to develop a mitigation model based on religious education for survivors.
Practical implications – The entire series of religious education processes carried out by MDMC for survivors, conceptually or in scientific theory, has meaning or is very significant in shaping survivors’ mental attitudes and religiosity.
Management of Character Education in Creating Student Morals: A Multiple-Case Study
Authors: Fanani Zainuddin , Basri  , Sonhadji Ahmad 
Published: May 2023

Purpose – Quality education with Islamic values will result from character education with good management. This study analyzes and plans character education in MAN 1 Malang Regency and MAN 1 Malang City while implementing and evaluating character education in these institutions. This study also looks at the role of character education in MAN 1 Malang Regency and MAN 1 Malang City.
Design/methods/approach – This research uses case studies and multi-case designs. In-depth interviews, participant observation, and documentation were used to collect data. To conclude, the data are presented in an interactive model. The data’s trustworthiness, transferability, dependence, and certainty were tested for validity. Analyze data with reflective thinking.
Findings – The findings of this study indicate that character education is planned using a curriculum that includes character education. Character education with good habits, role models, extracurricular activities, and fostering the organizational culture of character education, regular meetings, and home visits to assess the impact of character education on students’ morale by producing character education management. Based on the previous year’s evaluation, designing academic and non-academic curricula, managing the extracurricular environment, and creating a religious culture. Madrasa environment, teaching and learning activities, and extracurricular activities. The head of the madrasah conducts evaluation activities gradually, periodically, and continuously involving the waka and related fields and learning from the vision and mission of the madrasa, creating moral habituation, environmental protection, and cooperation with all stakeholders.
Research implications/limitations – The study highlights the significance of merging character education with Islamic values in two Islamic schools through good habits, role models, extracurricular activities, and organizational culture while stressing the importance of regular evaluations and collaboration among stakeholders. However, the research’s qualitative methods and limited scope may not be generalizable to all Islamic educational institutions.
Practical implications – Integrating character education in curricula, emphasizing good habits and extracurricular activities, continuous evaluations, and stakeholder collaboration can effectively promote Islamic values in educational institutions.
The Role of Parenting Styles in Internalizing Islamic Moderation Values in Children: A Phenomenological Study
Authors: Hamdun Dudung 
Published: May 2023

Purpose – This qualitative study investigates the pivotal role of parents in the internalization of Islamic moderation values in child development, as well as the determinants of parental behavior, knowledge, and practices. Additionally, the research identifies implications for further studies and practical applications.
Design/methodology/approach – The phenomenological methodology is employed to comprehend and describe these phenomena, delving into the essence of parents' experiences.
Findings – The results demonstrate that parents are responsible for shaping children's behavior and instilling Islamic moderation values. Factors such as parental experience and education, profound understanding, quality aspects, and parenting methods by exemplary parents serve as determinants of parental behavior, knowledge, and practices in incorporating Islamic moderation values in child development. Overall, the findings suggest that among all modifiable factors influencing a child's development, the quality of care children receive is of utmost importance, warranting further academic investigation.
Research implications/limitations – The study emphasizes the role of parents in the internalization of Islamic moderation values; however, it does not examine the long-term effects of such internalization on children's overall development and well-being.
Practical implications – This research offers valuable insights for practitioners, highlighting that parenting, when carried out effectively, can be a highly fulfilling role, bringing immense joy, pride, and happiness to a parent's life.
Multimedia-Influence-Achievement Model (MIAM)
Authors: Akwene Godwill Chenyuei , Fouda Marcel Ndjodo 
Published: May 2023

The recent outbreak of the COVID-19 pandemic has led to an increasing demand for new technologies to transmit learning content and facilitate student learning. This article aimed at presenting a new technology adoption model that examines the influence of multimedia exposure on learning motivation, and eventual student academic achievement. The current study focus propels the application of multimedia in education to facilitate students’ academic achievement. Using a sample of 354 students drawn from some secondary schools in Yaounde, data was collected through a questionnaire and analyzed using Structural Equation Modeling (SEM). The proposed new Multimedia-Influence-Achievement Model (MIAM) was tested and validated using SmartPLS 3.2.8 software. The analysis showed high factor loadings related to all the items indicating goodness of fit. The results showed that all six hypotheses expressed by the structural model were supported by the data. Multimedia exposure had a significant positive relationship with multimedia self-efficacy, attitude toward multimedia and learning motivation. Multimedia self-efficacy and attitude toward multimedia equally have significant positive relationship with learning motivation. Furthermore, the results proposed that learning motivation is a predictive determinant of student’s academic achievement. In light of the above results, identification of facilitating conditions is a prerequisite to introduction of multimedia technology in the teaching and learning process.
Transmedia strategies in school literary education: deconstructing kitsch and the semiotics of readerly creativity
Authors: Arkhangelsky Alexander , Novikova Anna 
Published: May 2023

Abstract
We consider the substitution of living classical texts with their simulacra, kitschy interpretations, to be one of the most important issues in literary education in schools. Traditional teaching methods and textbooks reproduce a set of pedagogical clichés. This leads to a loss of the skill of reading. As a result, the student gains a set of simple narratives about canonical texts, not the knowledge of them. The goal of our study is to give impetus to developing the classics. We think that this development is possible if teachers work with the text, starting with deconstruction of the narrative and clichés surrounding it, applying methods of analysis that are typical for the humanities, in particular semiotic analysis, formal analysis, and narrative analysis. Dominants and metaphors may become a starting point for transmedia extensions, which is extremely important for students’ subsequent independent creative work. We propose an approach to working with literary texts in a manner which stimulates the reader’s personal creativity in the process of becoming acquainted with classics. We have used the example of famous film adaptations and theatrical stagings of the novel War and Peace by Leo Tolstoy, as well as multimedia projects by trainees from grades 7–11.
Parodies in Chinese Government Work Reports
Authors: Hou Guojin , Jin Zixi 
Published: May 2023

Abstract
This study accounts for how parody enters such official political discourse as Chinese Government Work Reports (GWRs). It quantitatively and qualitatively studies parodies from 44 GWRs (1978–2021) via the convergence-economy, variation-effectiveness, and relevance model. Our findings are: 1) parodies have appeared more and more frequently in GWRs over the last 44 years; 2) word parodies occur more frequently in GWRs than phrase, sentence, and paragraph parodies; 3) brand-new parodies, of higher pragma-rhetorical values, are used in GWRs; 4) parodies tend to reoccur mimetically once utilized, for ready-made security and effectiveness; and 5) the increasing frequency of parodies is caused by the politicians’ quest for their identification-oriented “markedness effects.”
Design, synthesis, and in-silico study of new letrozole derivatives as prospective anticancer and antioxidant agents
Authors: Jihad Raad S. , Abdul-Rida Nabeel A. , Al-Shamari Amer M. J. , Al-Masoudi Najim A. , Saeed Bahjat A. 
Published: May 2023

Abstract
A new series of derivatives (compounds 8–20) of the breast antihormonal drug letrozole tagged with additional aryl groups were synthesized starting from the letrozole analog 7 via Suzuki cross-coupling reaction. Treatment of the ketone 9 with various aldehydes in base afforded the chalcone analogs 21–27. The structural assignments were done by IR, 1H, 13C and 2D NMR spectra. Compounds 13, 21–23, 25 and 26 have been selected for their anticancer activity against MCF-7 and WRL-68 cell lines. Compounds 13 and 22 were found to be the most potent anticancer agents with IC50 values of 34.75 and 58.79 (μg mL−1) (SI = 3.3 and 2.6, respectively). Molecular docking study of compounds 13 and 22 revealed hydrogen bond with the amino acids Arg115, Met374 and Met364 residues of the receptor 3EQM, respectively. Therefore, compounds 13 and 22 can be considered as promising anticancer agents due to their potent cytotoxic activity.