bluuebunny/crossref_metadata_2025_split huggingface dataset:
Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates
Authors: Nagini Siddavaram , Palrasu Manikandan , Bishayee Anupam 
Published: August 2023

AbstractNeem (Azadirachta indica A. Juss.), a versatile evergreen tree recognized for its ethnopharmacological value, is a rich source of limonoids of the triterpenoid class, endowed with potent medicinal properties. Extracts of neem have been documented to display anticancer effects in diverse malignant cell lines as well as in preclinical animal models that has largely been attributed to the constituent limonoids. Of late, neem limonoids have become the cynosure of research attention as potential candidate agents for cancer prevention and therapy. Among the various limonoids found in neem, azadirachtin, epoxyazadiradione, gedunin, and nimbolide, have been extensively investigated for anticancer activity. Azadirachtin, a potent biodegradable pesticide, exhibits profound antiproliferative effects by preventing mitotic spindle formation and cell division. The antiproliferative activity of gedunin has been demonstrated to be mediated primarily via inhibition of heat shock protein90 and its client proteins. Epoxyazadiradione inhibits pro‐inflammatory and kinase‐driven signaling pathways to block tumorigenesis. Nimbolide, the most potent cytotoxic neem limonoid, inhibits the growth of cancer cells by regulating the phosphorylation of keystone kinases that drive oncogenic signaling besides modulating the epigenome. There is overwhelming evidence to indicate that neem limonoids exert anticancer effects by preventing the acquisition of hallmark traits of cancer, such as cell proliferation, apoptosis evasion, inflammation, invasion, angiogenesis, and drug resistance. Neem limonoids are value additions to the armamentarium of natural compounds that target aberrant oncogenic signaling to inhibit cancer development and progression.
Slow‐wave substrate integrated suspended parallel strip line and its application to rat‐race coupler
Authors: Shen Huajiao , Wang Yongqiang , Meng Fanyi , Ma Kaixue 
Published: August 2023

AbstractThis paper presents a slow‐wave substrate integrated suspended parallel strip line (SW‐SISPSL) for the first time. The slow‐wave effect is produced by cascading high/low‐impedance SISPSL in the meander line configuration. Different from conventional single‐ended slow‐wave transmission lines, the proposed SW‐SISPSL supports differential signal transmission. The characteristic impedance and slow‐wave factor of the SW‐SISPSL are analyzed using equivalent circuit models. Using the proposed SW‐SISPSL and a SISPSL phase inverter, a very compact rat‐race coupler is implemented. The core circuit area of the slow‐wave rat‐race coupler is 0.083 λg × 0.089 λg, which is only 4.12% of the conventional topology.
Genetic structure of the Silver Chub indicates distinctiveness of Lake Erie population
Authors: Elbassiouny Ahmed A. , Fontenelle João Pedro , Kočovský Patrick M. , Mandrak Nicholas E. , Lovejoy Nathan R. 
Published: August 2023

Abstract

Objective
Silver Chub Macrhybopsis storeriana is a small riverine minnow endemic to North American fresh waters. Its range extends from the southern USA to southcentral Canada; the latter includes a rare lacustrine population in Lake Erie. Anthropogenic activities pose an immediate threat to several Silver Chub populations, currently categorized from special concern to threatened at the state level in the USA and federally and provincially not-at-risk to endangered in Canada. Several studies have examined the anthropogenic causes for the decline of Silver Chub populations, but conservation efforts have been hindered by the lack of knowledge of the population genetics of this species.

Methods
Here, we provide an assessment of the genetic diversity of Silver Chub populations across the USA and Canada using a fast-evolving mitochondrial gene, with particular focus on the Lake Erie population.

Result
We found the Lake Erie population to be divergent from all other populations, with nearly all the haplotypes sampled there being private.

Conclusion
Our study provides genetic evidence that the Silver Chub population in Lake Erie could be considered a separate conservation unit.
Medication use in a cohort of adults with chronic intestinal failure: A prospective cross‐sectional study
Authors: Deleenheer Barbara , Lauwers Nathalie , Spriet Isabel , Declercq Peter , Vanuytsel Tim 
Published: August 2023

AbstractBackgroundOral drug therapy may be compromised in chronic intestinal failure (IF) because of alterations in absorption and transit. Only scarce literature is available on which medication patients with chronic IF take in daily life. The aim was to describe the medication use in these patients.MethodsA medication history was obtained from adults with chronic IF treated in our tertiary care IF center. Degree of polypharmacy, drug classes, Biopharmaceutics Classification System classes, route of administration, and formulation of drugs were analyzed.ResultsFrom October 2019 until December 2020, 72 patients (35 patients with short bowel syndrome [SBS] and 37 patients without SBS) were included. Polypharmacy was seen in 85.7% of patients with SBS and 75.7% of patients without SBS. The top three drug classes were proton‐pump inhibitors, vitamin D or acetaminophen, and antimotility medication or laxatives/benzodiazepines. Approximately 25% of the drugs were classified as Biopharmaceutics Classification System class I drugs. In patients with SBS (78%) and patients without SBS (74.9%), most medication was taken orally, requiring gastrointestinal absorption of the active substance to be pharmacologically active. Most of these medications (77% in patients with SBS and 80.8% in patients without SBS) were formulated as a capsule or tablet, requiring disintegration and dissolution in the gastrointestinal tract before absorption can take place.ConclusionPolypharmacy was observed in most patients with chronic IF. Most medication was taken orally in formulations requiring disintegration, dissolution, and gastrointestinal absorption, which could be compromised in chronic IF.
Differences in self‐reported psychotic symptoms between patients with autism spectrum disorder and those with schizophrenia
Authors: Yamada Momoka , Sugawara Norio , Kawamata Yasushi , Yasui‐Furukori Norio 
Published: August 2023

AbstractAimPatients with autism spectrum disorder (ASD) are prone to develop overt psychosis and share symptom presentations with those with schizophrenia (SZ). This study aimed to explore differences in the distributions of psychotic symptoms among first‐visit patients with ASD, SZ, or a nonpsychiatric diagnosis (N‐PD).MethodsData from first‐visit patients were retrospectively collected from medical records from the Department of Psychiatry, Dokkyo Medical University Hospital between June 2019 and May 2021. A total of 254 patients with data on the PRIME Screen‐Revised (PS‐R) assessments were included in our analysis. In the hospital, all psychiatric diagnoses were based on the DSM‐5 diagnostic criteria.ResultsIn the ASD, SZ, and N‐PD groups, endorsements of perplexity and delusional mood were 15.6% (7/45), 41.5% (44/106), and 1.1% (1/88), and those of perceptual abnormalities were 11.1% (5/45), 40.6% (43/106), and 2.3% (2/88), respectively. Trend analysis clarified that the endorsement of these psychotic symptoms increased from N‐PD to ASD and SZ. In the multivariate‐adjusted multinomial logistic regression analysis, the ASD and N‐PD groups were compared with the SZ group. Higher age and the presence of perceptual abnormalities were associated with lack of an ASD diagnosis, whereas male sex, lack of perplexity and delusional mood, and lack of perceptual abnormalities were associated with N‐PD.ConclusionOur results are preliminary; however, a detailed assessment of positive symptoms might facilitate differentiation between ASD and SZ.
Phenotypic characteristics, healthcare use, and treatment in children with night cough compared with children with wheeze
Authors: Mallet Maria C. , Mozun Rebeca , Ardura‐Garcia Cristina , Pedersen Eva S. L. , Jurca Maja , Latzin Philipp ,   LUIS Study Group, Moeller Alexander , Kuehni Claudia E. 
Published: August 2023

AbstractObjectivesPopulation‐based studies of children with dry night cough alone compared with those who also wheeze are few and inconclusive. We compared how children with dry night cough differ from those who wheeze.MethodsLuftiBus in the school is a population‐based study of schoolchildren conducted between 2013 and 2016 in Zurich, Switzerland. We divided children into four mutually exclusive groups based on reported dry night cough (henceforth referred as “cough”) and wheeze and compared parent‐reported symptoms, comorbidities, exposures, FeNO, spirometry, and healthcare use and treatment.ResultsAmong 3457 schoolchildren aged 6–17 years, 294 (9%) reported “cough,” 181 (5%) reported “wheeze,” 100 (3%) reported “wheeze and cough,” and 2882 (83%) were “asymptomatic.” Adjusting for confounders in a multinomial regression, children with “cough” reported more frequent colds, rhinitis, and snoring than “asymptomatic” children; children with “wheeze” or “wheeze and cough” more often reported hay fever, eczema, and parental histories of asthma. FeNO and spirometry were similar among “asymptomatic” and children with “cough,” while children with “wheeze” or “wheeze and cough” had higher FeNO and evidence of bronchial obstruction. Children with “cough” used healthcare less often than those with “wheeze,” and they attended mainly primary care. Twenty‐two children (7% of those with “cough”) reported a physician diagnosis of asthma and used inhalers. These had similar characteristics as children with wheeze.ConclusionOur representative population‐based study confirms that children with dry night cough without wheeze clearly differed from those with wheeze. This suggests asthma is unlikely, and they should be investigated for alternative aetiologies, particularly upper airway disease.
The impact of obstructive sleep apnea in children with sickle cell disease and asthma
Authors: Feld Lance , Bhandari Anita , Allen Julian , Saxena Shikha , Stefanovski Darko , Afolabi‐Brown Olufunke 
Published: August 2023

AbstractIntroductionAsthma and obstructive sleep apnea (OSA) are chronic diseases that disproportionately affect children with sickle cell disease (SCD). The literature describes the negative impact that both conditions have on children with SCD separately; however, the effect of OSA on asthmatic children with OSA is less specific. We hypothesized that the presence of OSA in children with SCD and asthma is associated with specific hematologic markers, worse clinical outcomes, and greater healthcare utilization.MethodsWe retrospectively evaluated children with both SCD and asthma who underwent polysomnography (PSG). We assessed their demographic information, PSG data, hematologic indices, and healthcare utilization based on the concurrent presence of OSA.ResultsFifty‐nine percent of the cohort had OSA with a lower oxygen saturation (SpO2) nadir (87% vs. 93%, p < 0.001) and a lower median daytime SpO2 (96.5% vs. 98.5%, p < 0.05); those with OSA were more likely to have the hemoglobin SS genotype (86% vs. 46.5%, p = 0.03). Additionally, those with OSA had a higher mean corpuscular volume (87 vs. 77.2 fL, p = 0.03) and reticulocyte count (10.1% vs. 5.5%, p < 0.01). There was no difference in asthma severity or healthcare utilization between those with OSA and those without OSA.DiscussionOverall, children with SCD and asthma might be at increased risk for developing OSA, and screening for sleep‐disordered breathing should be incorporated as part of their routine care.
Structure and energetics of hydroxyl‐terminated polybutadiene via density functional theory
Authors: Buszek Robert J. , Moore Levi M. J. , Lonnecker Alexander T. , Ghiassi Kamran B. , Boatz Jerry A. 
Published: August 2023

AbstractHydroxyl‐terminated polybutadiene (HTPB) is a commonly used binding polymer in industry to produce polyurethanes. HTPB synthesis via allylic radical propagation leads to varied compositions and conformations that govern the bulk physical and mechanical properties of this polymer. While HTPB is incredibly well studied, its enthalpy of formation is still an open question and is critical to understanding the energetic contributions of the binding polymer in propellant formulations. This study investigates a series of HTPB polymers of experimentally relevant size and composition to understand the effects of conformations and monomer compositions on enthalpies of formation. The distribution of component monomer species comprising HTPB polymers is shown to have a significant effect on the condensed phase enthalpy of formation. The present study provides a best estimate of 331.2±50.3 kJ/mol or 150.7±22.9 kJ/kg for the condensed phase enthalpy of formation for commercially available HTPB formulations. The effects of the polymer folding motifs are smaller but distinct, with more highly folded structures exhibiting lower enthalpies of formation.
Pesticide use, arthropod fauna and fruit damage in apple orchards in a Nordic climate
Authors: Hatteland Bjørn Arild , Andrade Moral Rafael De , Jaastad Gunnhild , Myren Gaute , Bjotveit Endre , Sekse Irén Lunde , Westrum Karin , Trandem Nina 
Published: August 2023

AbstractBACKGROUNDIntegrated pest management (IPM) has a long history in fruit production and has become even more important with the implementation of the EU directive 2009/128/EC making IPM mandatory. In this study, we surveyed 30 apple orchards in Norway for 3 years (2016–2018) monitoring pest‐ and beneficial arthropods as well as evaluating fruit damage. We obtained growers’ diaries of pest management and used these data to study positive and negative correlations of pesticides with the different arthropod groups and damage due to pests.RESULTSIPM level had no significant effects on damage of harvested apples by arthropod pests. Furthermore, damage by arthropods was mainly caused by lepidopteran larvae, tortricids being especially important. The number of insecticide applications varied between 0 and 3 per year (mean 0.8), while acaricide applications varied between 0 and 1 per year (mean 0.06). Applications were often based on forecasts of important pest species such as the apple fruit moth (Argyresthia conjugella). Narrow‐spectrum insecticides were commonly used against aphids and lepidopteran larvae, although broad‐spectrum neonicotinoid (thiacloprid) insecticides were also applied. Anthocorid bugs and phytoseiid mites were the most abundant natural enemies in the studied orchards. However, we found large differences in abundance of various “beneficials” (e.g., lacewings, anthocorids, parasitic wasps) between eastern and western Norway. A low level of IPM negatively affected the abundance of spiders.CONCLUSIONLepidoptera was found to be the most important pest group in apple orchards. Insecticide use was overall low, but number of spray applications and use of broad‐spectrum insecticides varied between growers and regions. IPM level did not predict the level of fruit damage by insects nor the abundance of important pests or most beneficial groups in an apple orchard. © 2023 The Authors.Pest Management Sciencepublished by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Practicing Taichi together in the park: A case study of Taichiscape and older people's wellbeing
Authors: Zhang Bo , Huang Yuling 
Published: August 2023

AbstractInspired by Gesler's notion of therapeutic landscapes, this paper proposes a new concept, ‘Taichiscape’, to demonstrate how older people obtain a sense of healing and wellbeing through the practice of group Taichi in the park. Based on extensive fieldwork with 42 older people between 2020 and 2021 in Tianhe Park in Guangzhou, China, the paper presents Taichiscape in three aspects: (1) From the physical aspect, the Chinese traditional health concepts of ‘becoming one with nature’ and the form of Yin‐Yang balance, allowing older people to maintain closeness and be immersed in the natural environment, rhythmically connecting with natural elements, and relaxing via flourishing positive affect (PA); (2) In terms of socialising, older people practice Taichi together to establish a synchronised rhythm in a spatiotemporal order and collectively create a positive social atmosphere, where they gain a sense of PA through belonging, self‐esteem and pleasure; (3) At the body level, through the rhythm of slowness, older people enjoy diverse and bodily sensations that temporally nurture their minds and souls and initiate the therapeutic process of embodied restoration. Theoretically, the healing power of Taichiscape is habitually, contextually, and temporally constructed through a dynamic creation between human and nonhuman elements. This work extends knowledge of therapeutic landscapes by underlining how slowness in Taichiscape can be seen as a sign of progress and an active pursuit of wellbeing, and older people's sense of control over their lives.
Leaving the parental home in post‐apartheid South Africa
Authors: Thornton Amy 
Published: August 2023

AbstractThe process by which young people leave home in South Africa is central for understanding the lives of the country's young adult population, as well as, their role in the structural household change that has occurred over the post‐apartheid period. However, hardly any quantitative work has been conducted on this process and no work exists on trends. This study provides nationally representative trends of home‐leaving for young adults in South Africa for the first time using a stacked series of annual cross‐sections between 1995 and 2011. Different home‐leaving rates by race converged in the late 90s and steadied in the 2000s. Most South Africans only left home by age 25—but whether this can be interpreted as ‘delayed’ or not is complicated by diverse family patterns and the presence of stretched households. Home‐leavers are especially dependent on labour market income in the absence of social grants targeted at the large unemployed young adult population. Since young women face higher unemployment rates than young men, women were notably more reliant than men on marriage as a pathway out of the parental home. Over time, young male home‐leavers are living alone at higher rates, meaning they have contributed to general household proliferation.
The risk profile change in patients with severe chronic thromboembolic pulmonary hypertension treated with subcutaneous treprostinil
Authors: Jansa Pavel , Kopeć Grzegorz , Torbicki Adam , Sadushi‐Kolici Roela , Campean Ioana‐Alexandra , Halank Michael , Simkova Iveta , Steringer‐Mascherbauer Regina , Salobir Barbara , Klepetko Walter , Lindner Jaroslav , Lang Irene M. 
Published: August 2023

AbstractChronic thromboembolic pulmonary hypertension (CTEPH) is successfully treatable with pulmonary endarterectomy (PEA), balloon pulmonary angioplasty, and medical therapy. Registry to Evaluate Early and Long‐Term Pulmonary Arterial Hypertension Disease Management risk score (RRS) is able to predict long‐term outcome in inoperable patients or in patients with residual PH after surgery. We performed a post hoc analysis of RRS in patients who were enrolled in the CTREPH study (NCT01416636), a randomized, double‐blind clinical trial comparing high‐dose and low‐dose subcutaneous (SC) treprostinil in patients with severe CTEPH that was classified by an interdisciplinary CTEPH team as nonoperable, or as persistent or recurrent pulmonary hypertension after PEA. Baseline mean RRS was similar in both treatment groups (8.7 in high‐dose arm vs. 8.6 in low‐dose arm), but mean RRS change from baseline to Week 24 was greater in the high‐dose treprostinil group than in the low‐dose treprostinil group (−0.88 vs. −0.17). The difference in RRS change from baseline to Week 24 between high dose versus low dose was statistically significant with mean difference of −0.70 (95% confidence interval: −1.36 to −0.05, p = 0.0352), and was driven mainly by improvement of World Health Organization functional class and N‐terminal pro‐brain natriuretic peptide concentration. SC treprostinil therapy administered in standard dose had positive effect on the risk profile measured by RRS in patients with inoperable or persistent/recurrent severe CTEPH. Although our study was limited by the small sample size and post hoc nature, assessment of risk profile is of great importance to this particular patient population with very poor prognosis.
Human papillomavirus vaccination uptake in the Rio Grande Valley of Texas: Results from a pilot community‐based educational and school‐based vaccination program
Authors: Rodriguez Ana M. , Do Thuy Quynh N. , Chen Lu , Schmeler Kathleen M. , Montealegre Jane R. , Kuo Yong‐Fang 
Published: August 2023

AbstractObjectiveTo pilot and evaluate a combined community‐based education and middle school‐based human papillomavirus (HPV) vaccination program in a rural, medically underserved Texas area.MethodsThe study included 2276 students enrolled at three Rio Grande City Grulla Independent School District, (RGCGISD, formerly Rio Grande City Consolidated Independent School District) middle schools (08/2016–02/2020). The intervention took place in a middle school setting with the community‐based, physician‐led HPV education campaign starting in 08/2016, and a school‐based vaccination program (Phase 1: 08/2017; Phase 2: 08/2018). Pre‐ and postintervention HPV vaccination rates were tracked against 2016 National Immunization Survey‐Teen rates (target: initiation 49.3%; completion 32.9%). Summary statistics were stratified by middle school.ResultsIn 2016, HPV vaccine initiation and completion rates for RGCGISD were lower than the national average (39.7% and 17.9%, respectively). In 2020, the overall HPV vaccine initiation rate increased by 58.0% (from 39.7% to 68.5%) and completion rates doubled (from 17.9% to 42.1%). The median age at HPV vaccine initiation and HPV vaccine completion (range) were 11.2 years (9–15) and 12 years (9–15). The median interval between HPV vaccine doses (range) was 287 days (36–1576). There were different between males and females among the three middle schools.ConclusionsMiddle schools serve as a feasible, effective interventional setting for delivering and increasing HPV education and vaccine uptake among adolescents, which offers substantial long‐term health benefits.