bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resilience in children with chronic illness: Tests of the shift-and-persist and skin-deep resilience theories
Authors: Chen Edith , Jiang Tao , Chen Michelle A. , Chiu Rachel Y. , Miller Gregory E. 
Published: June 2023

AbstractThis study investigated, and discusses the integration of, the shift-and-persist (SAP) and skin-deep resilience (SDR) theories. The SAP theory states that the combination of shifting (adjusting oneself to stressful situations through strategies like emotion regulation) and persisting (enduring adversity with strength by finding meaning and maintaining optimism) will be beneficial to physical health in children experiencing adversity. The SDR theory states that high striving/self-control will be beneficial to mental health but detrimental to physical health among those confronting adversity. This study investigated 308 children ages 8–17 experiencing the adversity of a chronic illness (asthma). SAP and SDR (striving/self-control) were assessed via questionnaires, and physical health (asthma symptoms, inflammatory profiles), mental health (anxiety/depression, emotional functioning), and behavioral (medication adherence, activity limitations, collaborative relationships with providers) outcomes were measured cross-sectionally. SAP was associated with better physical health, whereas SDR was associated with worse physical health. Both were associated with better mental health. Only SDR was associated with better behavioral outcomes. Implications of findings and discussion of how to integrate these theories are provided. We suggest that future interventions might seek to cultivate both SAP and SDR to promote overall better health and well-being across multiple domains in children experiencing adversity.
Comparison of echocardiographic aortic stiffness index measurements and pulse wave velocity measurements in obese and overweight children
Authors: Kavgacı Akif , İncedere Fatma , Tunaoğlu Sedef , Karabörk Muhammet , Büyükkaragöz Bahar , Leventoğlu Emre , Oğuz Deniz , Kula Serdar , Terlemez Semiha 
Published: June 2023

AbstractBackground:Aortic/arterial stiffness is a reliable, independent predictor and a risk factor for cardiovascular mortality. Arterial stiffness is assessed by pulse wave velocity and echocardiography. The purpose of this study is to analyse aortic/arterial stiffness in patients using echocardiographic and pulse wave velocity techniques.Materials and Methods:The participants of this study consisted of 62 patients who presented to the Gazi University Pediatric Endocrinology and Pediatric Cardiology outpatient clinics, including 21 obese, 20 overweight, and 21 normal-weight patients. Echocardiography was performed on all patients, and echocardiographic measurements were compared to pulse wave velocity measurements.Results:The mean (min-max) arterial strain measurements were 0.146 ± 0.0 (0.06–0.3) in the obese group and 0.106 ± 0.0 (0.05–0.18) in the overweight group. In comparison to the overweight group, the obese group had greater arterial strain measurements. The pulse wave velocity measurements in the obese and overweight groups were greater than those in the normal weight group (p > 0.05). Elastic modulus and aortic stiffness ß index values were shown to be positively correlated with pulse wave velocity measurements in the obese group (r = 0.56, r = 0.53, respectively; p = 0.008, p = 0.01, respectively). Systolic and diastolic blood pressure measurements were correlated with pulse wave velocity measurements in the obese group (r = 0.98, p = 0.0001, respectively).Conclusion:In our study, echocardiographic aortic measurements showing the vessel wall were correlated with pulse wave velocity measurements. Echocardiographic evaluation should be included in the routine follow-up of patients because pulse wave velocity measurement devices are not available in all centres, echocardiography is available in many centres, it is easily applicable, and it facilitates the follow-up of patients.
Finding the fun: Towards a playful archaeology
Authors: Politopoulos Aris , Mol Angus A.A. , Lammes Sybille 
Published: June 2023

AbstractGames and other forms of play are core human activities, as vitally constitutive of cultural and social practices in the past as they are today. Consequently, play, games and fun should be central in archaeological theory, but our review shows they are anything but. Instead, very few studies deal with these concepts at all, and most of those that do focus on how the affordances play offers link it to ritual, power or other ‘more serious’ phenomena. Here, we offer an explanation as to why play has taken such a backseat in archaeological thought and practice, relating it to the ambivalent aesthetics of having fun with the past in our own discipline. Building on our own playful practices and those of other scholars in the ancient board gaming and archaeogaming communities, we propose a move towards a more playful archaeology, which can provide us with a new window into the past as well as into our own professional practices.
Bid‘a and evolving conceptions of the shari‘a in Qing and Republican China
Authors: Glasserman Aaron Nathan 
Published: June 2023

Abstract
In this article I revise the conventional account of the contestation over Islamic reform in late Qing and Republican China. I argue that previous scholarship has overlooked important similarities between so-called “reformists” or “Yihewani” and “traditionalists” or “Gedimu.” Based on an analysis of several texts and their exposition of the concept of bid‘a, I show that scholars associated with opposite sides of this divide in the early twentieth century shared a legalistic understanding of the shari‘a as a system of categories for classifying human action; and that this classificatory conception of the shari‘a differed from the practice-centered approach reflected in earlier Chinese Islamic works.
Causal Associations of Air Pollution With Cardiovascular Disease and Respiratory Diseases Among Elder Diabetic Patients
Authors: Li Zhiwei , Lv Shiyun , Lu Feng , Guo Moning , Wu Zhiyuan , Liu Yue , Li Weiming , Liu Mengmeng , Yu Siqi , Jiang Yanshuang , Gao Bo , Wang Xiaonan , Li Xia , Wang Wei , Liu Xiangtong , Guo Xiuhua 
Published: June 2023

AbstractExtensive researches have linked air pollutants with cardiovascular disease (CVD) and respiratory diseases (RD), however, there is limited evidence on causal effects of air pollutants on morbidity of CVD or RD with comorbidities, particularly diabetes mellitus in elder patients. We included hospital admissions for CVD or RD among elder (≥65 years) diabetic patients between 2014 and 2019 in Beijing. A time‐stratified case‐crossover design based on negative‐control exposure was used to assess causal associations of short‐term exposure to air pollutants with CVD and RD among diabetic patients with the maximum lag of 7 days. A random forest regression model was used to calculate the contribution magnitude of air pollutants. A total of 493,046 hospital admissions were recorded. Per 10 μg/m3 uptick in PM1, PM2.5, PM10, SO2, NO2, O3, and 1 mg/m3 in CO was associated with 0.29 (0.05, 0.53), 0.14 (0.02, 0.26), 0.06 (0.00, 0.12), 0.36 (0.01, 0.70), 0.21 (0.02, 0.40), −0.08 (−0.25, 0.09), and 4.59 (0.56, 8.61) causal effect estimator for admission of CVD among diabetic patients, corresponding to 0.12 (0.05, 0.18), 0.09 (0.05, 0.13), 0.05, 0.23 (0.06, 0.41), 0.10 (0.02, 0.19), −0.04 (−0.06, −0.01), and 3.91(1.81, 6.01) causal effect estimator for RD among diabetic patients. The effect of gaseous pollutants was higher than particulate pollutants in random forest model. Short‐term exposure to air pollution was causally associated with increased admission of CVD and RD among elder diabetic patients. Gaseous pollutants had a greater contribution to CVD and RD among elder diabetic patients.
Observation‐Driven Characterization of Soil Moisture‐Precipitation Interactions in the Central United States
Authors: Ford Trent W. , Steiner Joshua , Mason Bridgette , Quiring Steven M. 
Published: June 2023

AbstractSoil moisture feedbacks that initiate, enhance, or suppress convection initiation and precipitation are important components of regional hydroclimatology. However, soil moisture feedbacks and the processes through which they operate are notoriously challenging to observe and study outside of model environments. In this study, we combine a climatological assessment of event frequency‐based measurements of soil moisture‐precipitation coupling in the central United States with a process‐based analysis of the mechanisms by which wet‐ and dry‐soil feedbacks may operate in the region. We use the Thunderstorm Observation by Radar algorithm to identify the location of convection initiation, circumventing the issue of using precipitation accumulation as a proxy for convection initiation. Results show substantial spatial variability in the climatological sign and strength of soil moisture‐precipitation coupling in the central United States, including regions that exhibit signs of both wet‐ and dry‐soil feedbacks. Within the regions with the strongest feedback signals, we find consistently strong coupling between soil moisture and the partitioning of surface heat flux, and strong coupling between surface heat flux—particularly sensible heat flux—and diurnal change in planetary boundary layer height. In all three regions assessed, the process‐based metrics confirmed the potential of wet‐ and/or dry‐soil feedbacks leading to convection initiation.
Six Hundred Years of Reconstructed Atmospheric River Activity Along the US West Coast
Authors: Borkotoky Swatah Snigdha , Williams A. Park , Steinschneider Scott 
Published: June 2023

AbstractAtmospheric rivers (AR) are critically important to water resources management along the US west coast, driving variability in both droughts and floods across the region. Inter‐annual variability of ARs is well documented in the instrumental record back to the mid‐twentieth century, but long‐term variations in the frequency and landfall location of ARs along the US west coast are poorly understood due to limited records. This limitation impedes the ability to contextualize emerging trends and projections of AR activity. Here we use station‐based records of daily precipitation and tree‐ring records to present novel, spatially explicit estimates of daily AR occurrences in the first half of the twentieth century and annual AR counts over the last 600 years. First, we use neural networks and daily precipitation across Western North America to classify the daily occurrence of AR landfalls in three regions along the US west coast during the cold season back to 1916 CE. Then, we reconstruct the annual frequency of AR landfalls in those same regions back to 1400 CE using a gridded, tree‐ring based reconstruction of the standardized precipitation index and a Poisson regression framework. The skillful reconstruction of daily and annual AR occurrences provides previously unavailable estimates of AR landfall variability and highlights new peaks in AR activity and modes of low‐frequency variability prior to the instrumental record. Our reconstructions suggest that the average latitude of AR landfall has varied considerably on multi‐decadal scales over the last 600 years, but without any discernible trends beyond this quasi‐oscillatory behavior.
GOLD Synoptic Observations of Quasi‐6‐Day Wave Modulations of Post‐Sunset Equatorial Ionization Anomaly During the September 2019 Antarctic Sudden Stratospheric Warming
Authors: Gan Q. , Oberheide J. , Goncharenko L. , Qian L. , Yue J. , Wang W. , McClintock W. E. , Eastes R. W. 
Published: June 2023

AbstractUsing observations from the Global‐scale Observations of the Limb and Disk (GOLD) mission, we investigate post‐sunset ionospheric responses to the September 2019 Antarctic sudden stratospheric warming –first ever from a synoptic perspective. Observations reveal a prevalent quasi‐6‐day periodicity in the equatorial ionization anomaly region over South America and the Atlantic, coincident with enhanced quasi‐6‐day wave (Q6DW) activity in the mesosphere (Liu et al., 2021, https://doi.org/10.1029/2020JA028909). The atmosphere‐ionosphere coupling via large‐scale waves is rarely studied over the ocean due to the lack of observations. More importantly, further analyses suggest that multiple pathways are involved in transmitting the quasi‐6‐day periodicity from the middle atmosphere into the post‐sunset F‐region ionosphere, including modulation of F‐region field aligned winds and pre‐reversal enhancements by the tides and or Q6DW. A remarkable depletion in electron density, attributable to the overall change in thermosphere composition driven by the dissipative tides and or Q6DWs, is also seen during the period of enhanced Q6DW activity.
Extreme Events and Probability Analysis Along the United States East Coast Based on High Spatial‐Coverage Reconstructed Storm Surges
Authors: Yang Lianjun , Jin Taoyong , Xiao Mingyu , Gao Xianwen , Jiang Weiping , Li Jiancheng 
Published: June 2023

AbstractAnalyzing the features of extreme events and estimating their probabilities robustly require high spatial coverage, high temporal resolution, and sufficiently long storm surge (SS) records. However, in situ observations cannot always meet these demands due to spatiotemporal sparseness. Here, we proposed a novel regional all‐site modeling framework based on a machine learning method, the extreme gradient boosting tree. This framework can reconstruct long SS records simply and quickly and can estimate storm surges simultaneously at both gauged and ungauged locations. Compared to in situ observations, the distribution patterns of SS variations during extreme events can be recognized easily from the reconstructed hourly SS data set. Since its available record is longer than 60 years (1959–2020), the estimation uncertainties of extreme event probabilities are significantly decreased. Noticeably high extreme SS return levels were found along the coast of the northern Gulf of Mexico, which should be given great attention.
Optical Properties of Boundary Layer Aerosols From High Spectral Resolution Lidar Measurements in a Polluted Urban Environment (Seoul, Korea)
Authors: Park Soojin , Kim Man‐Hae , Park Jong‐Uk , Yeo Huidong , Holz Robert E. , Kuehn Ralph E. , Eloranta Edwin W. , Omar Ali H. , Park Jin‐Soo , Ahn Joonyoung , Kim Sang‐Woo 
Published: June 2023

AbstractContinuous measurements of aerosol extinction coefficient (σext) from the High Spectral Resolution Lidar (HSRL) in Seoul from 2016 to 2018 were used to investigate the diurnal variation of the aerosol optical depth (AOD). Nighttime AOD displayed a larger mean and standard deviation (0.45 ± 0.47) than daytime (0.40 ± 0.29). Hygroscopic growth of aerosols under humid conditions was a key factor in the relative enhancement of nighttime AOD. Taking advantage of the HSRL's vertically resolved measurements, the contribution of aerosols within the boundary layer (BL) and free troposphere (FT) to AOD and its temporal variation were investigated. Unlike the diurnal AOD variation, AOD within the BL (AODBL) showed similar diurnal variations with the mixing layer height (MLH), displaying lower nighttime values with a peak around 14–15 local standard time. However, the low correlation between MLH and AODBL (R2 = 0.06) implied that MLH was not the sole deterministic factor of AODBL. A larger AOD of FT aerosols (AODFT) was observed during spring due to frequent elevated dust layers. Using mean σext within the BL and surface PM10 concentrations, the mass extinction efficiency (MEE) of aerosols in Seoul was estimated. The PM10 MEE showed a mean of 5.40 g m−2 and displayed significant variability by PM2.5 to PM10 ratio, season, and ambient relative humidity. The uncertainty of estimated surface PM10 concentrations was minimized when the seasonality and humidity factor in MEE were taken into account (the normalized mean bias decreased from 10.6%, using a single MEE value, to 6.2%).
Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders
Authors: Saenz de Viteri Stacey , Zhang Jian , Johnson Emma C. , Barr Peter B. , Edenberg Howard J. , Hesselbrock Victor M. , Nurnberger John I. , Pandey Ashwini K. , Kamarajan Chella , Kinreich Sivan , Tischfield Jay A. , Plawecki Martin H. , Kramer John R. , Lai Dongbing , Kuperman Samuel , Chan Grace , McCutcheon Vivia V. , Bucholz Kathleen K. , Porjesz Bernice , Meyers Jacquelyn L. 
Published: June 2023

AbstractRecent genome-wide association studies (GWAS) have identified genetic markers of post-traumatic stress disorder (PTSD) in civilian and military populations. However, studies have yet to examine the genetics of PTSD while factoring in risk for alcohol dependence, which commonly co-occur. We examined genome-wide associations for DSM-IV PTSD among 4,978 trauma-exposed participants (31% with alcohol dependence, 50% female, 30% African ancestry) from the Collaborative Study on the Genetics of Alcoholism (COGA). We also examined associations of polygenic risk scores (PRS) derived from the Psychiatric Genomics Consortium (PGC)-PTSD Freeze 2 (N = 3533) and Million Veterans Program GWAS of PTSD (N = 5200) with PTSD and substance dependence in COGA, and moderating effects of sex and alcohol dependence. 7.3% of COGA participants met criteria for PTSD, with higher rates in females (10.1%) and those with alcohol dependence (12.3%). No independent loci met genome-wide significance in the PTSD meta-analysis of European (EA) and African ancestry (AA) participants. The PGC-PTSD PRS was associated with increased risk for PTSD (B = 0.126, p < 0.001), alcohol dependence (B = 0.231, p < 0.001), and cocaine dependence (B = 0.086, p < 0.01) in EA individuals. A significant interaction was observed, such that EA individuals with alcohol dependence and higher polygenic risk for PTSD were more likely to have PTSD (B = 0.090, p < 0.01) than those without alcohol dependence. These results further support the importance of examining substance dependence, specifically alcohol dependence, and PTSD together when investigating genetic influence on these disorders.
Plasma concentrations of lysophosphatidic acid and the expression of its receptors in peripheral blood mononuclear cells are altered in patients with cocaine use disorders
Authors: Flores-López María , García-Marchena Nuria , Pavón-Morón Francisco J. , Requena-Ocaña Nerea , Sánchez-Marín Laura , Martín-Chaves Laura , García-Medina Mónica , Pedraza Carmen , Castilla-Ortega Estela , Ruiz Juan J. , Rodríguez de Fonseca Fernando , Araos Pedro , Serrano Antonia 
Published: June 2023

AbstractWe have recently reported alterations in the plasma concentrations of lysophosphatidic acid (LPA) in patients with substance use disorders. In order to further explore the potential role of the LPA signaling system as biomarker in cocaine use disorders (CUD) we conducted a cross-sectional study with 105 patients diagnosed with CUD and 92 healthy controls. Participants were clinically evaluated and blood samples were collected to determine plasma concentrations of total LPA and LPA species (16:0-, 18:0-, 18:1-, 18:2-, and 20:4-LPA), and the gene expression of LPA1 and LPA2 receptors in peripheral blood mononuclear cells. We found that patients with CUD had significantly lower plasma concentration of the majority of LPA species, while the mRNA expression of LPA1 receptor was found to be higher than controls. Moreover, we found a positive association between plasma concentration of 20:4-LPA and relevant CUD-related variables: age of onset cocaine use and length of cocaine abstinence. The statistical analysis revealed sex differences in concentrations of total LPA and LPA species, and women showed higher LPA concentrations than men. Furthermore, studies in rats of both sexes showed that plasma concentrations of total LPA were also altered after acute and chronic cocaine administration, revealing a sexual dimorphism in these effects. This study found alterations on the LPA signaling system in both, patients with CUD and rats treated with cocaine. Our results demonstrate that LPA signaling is impacted by CUD and sex, which must be taken into consideration in future studies evaluating LPA as a reliable biomarker for CUD.
RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury
Authors: Liu Pei-Yao , Chen Chih-Yuan , Lin Yu-Lung , Lin Chien-Ming , Tsai Wen-Chiuan , Tsai Yu-Ling , Lin Gu-Jiun , Chen Yu-Guang , Wang Shih-Yun , Sun Rui-Nong , Huang Yu-Chuan , Chang Hung , Chen Ying-Chuan 
Published: June 2023

AbstractAcute lung injury (ALI) is characterised by severe pulmonary inflammation, alveolar-capillary barrier disruption, and pulmonary oedema. Therefore, establishing effective therapeutic targets for ALI prevention is crucial. The present study reports a novel function of RNF128 in regulating LPS-induced ALI. Severe lung damage and increased immune cell infiltration were detected in RNF128-deficient mice. In vitro experiments revealed that RNF128 inhibits neutrophil activation by binding to myeloperoxidase (MPO) and reducing its levels and activity. Moreover, RNF128 regulates alveolar macrophage activation and neutrophil infiltration by interacting with TLR4, targeting it for degradation, and inhibiting NF-κB activation, hence decreasing pro-inflammatory cytokines. Our results demonstrate for the first time that RNF128 is a negative regulator of MPO and TLR4 in neutrophils and alveolar macrophages, respectively. However, AAV9-mediated RNF128 overexpression alleviated lung tissue damage and reduced inflammatory cell infiltration. Thus, RNF128 is a promising therapeutic candidate for pharmacological interventions in ALI.
TRPS1 regulates the opposite effect of progesterone via RANKL in endometrial carcinoma and breast carcinoma
Authors: Yang Linlin , Fan Qiong , Wang Jing , Yang Xiaoming , Yuan Jiangjing , Li Yuhong , Sun Xiao , Wang Yudong 
Published: June 2023

AbstractMedroxyprogesterone (MPA) has therapeutic effect on endometrial carcinoma (EC), while it could promote the carcinogenesis of breast cancer (BC) by activating receptor activator of NF-kB ligand (RANKL). However, the selective mechanism of MPA in endometrium and breast tissue remains obscure. Multiomics analysis of chromatin immunoprecipitation sequencing (ChIP-seq) and RNA sequencing (RNA-seq) were performed in cell lines derived from endometrial cancer and mammary tumor to screen the differential co-regulatory factors of progesterone receptor (PR). Dual-luciferase assays and ChIP-PCR assays were used to validate the transcriptional regulation. Co-immunoprecipitation (Co-IP) and immunofluorescence assays were carried out to explore molecular interactions between PR, the cofactor transcriptional repressor GATA binding 1 (TRPS1), and histone deacetylase 2 (HDAC2). Subsequently, human endometrial cancer/breast cancer xenograft models were established to investigate the regulation effect of cofactor TRPS1 in vivo. In the current study, we found that MPA downregulated RANKL expression in a time- and dose-dependent manner in EC, while had the opposite effect on BC. Then PR could recruit cofactor TRPS1 to the promoter of RANKL, leading to histone deacetylation of RANKL to repress its transcription in EC, whereas MPA disassociated the PR/TRPS1/HDAC2 complex to enhance RANKL histone acetylation in BC. Therefore, TRPS1, the coregulator recruited by PR played a critical role in the selective mechanism of progesterone in EC and BC and could become a potential candidate for targeted therapy to improve the anticancer effect of MPA on EC and avoid its carcinogenic effect on BC.