bluuebunny/crossref_metadata_2025_split huggingface dataset:
The diagnosis of hypophosphatasia in children as a multidisciplinary effort: an expert opinion
Authors: Baroncelli G. I. , Carlucci G. , Freri E. , Giuca M. R. , Guarnieri V. , Navarra G. , Toschi B. , Mora S. 
Published: September 2023

AbstractHypophosphatasia (HPP) is a rare genetic disorder in which pathogenic variants of the ALPL gene lead to a marked decrease of tissue non-specific alkaline phosphatase (TNSALP) activity. Although HPP is a systemic disorder, its clinical manifestations are more evident on bones, teeth, muscle and central nervous system. The clinical spectrum ranges from severe forms with extreme skeletal deformities, respiratory impairment, seizures, to very mild forms with onset in late adulthood and few clinical signs. The diagnosis can be suspected by measurement of TNSALP activity, but the insufficient awareness among health professionals and the lack of official guidelines are responsible for delayed diagnosis in children with HPP. The purpose of the current document is to provide an expert opinion directed at optimizing the diagnostic pathway of pediatric HPP. From April to December 2022, a multidisciplinary working group of 6 experts including two pediatric endocrinologists, a pediatric neurologist, a pediatric odontologist, a clinical geneticist, and a molecular biologist gathered in a series of periodic meetings to discuss the main issues related to the diagnosis of HPP in children and formalize an Expert Opinion statement. The experts agreed on a diagnostic trail that begins with the recognition of specific clinical signs, leading to biochemical analyses of TNSALP activity and vitamin B6 serum concentration. Very important are the neurological and dental manifestation of the disease that should be thoroughly investigated. The evaluation of TNSALP activity must consider sex and age variability and low activity must be persistent. Repeated blood measurements are thus necessary. The molecular analysis is then mandatory to confirm the diagnosis and for genetic counseling.
Sindrome dell’ovaio policistico: ruolo del glucagon-like peptide 1 (GLP-1) nella regolazione dell’asse ipotalamo-ipofisi-ovaio
Authors: Pugliese Gabriella , de Alteriis Giulia , Savastano Silvia 
Published: September 2023

SommarioL’obesità e l’insulino-resistenza associate alla sindrome dell’ovaio policistico (PCOS) hanno stimolato studi clinici sull’efficacia degli agonisti recettoriali del Glucagon-like Peptide 1 (GLP-1RA) nella perdita di peso e nel miglioramento del metabolismo glucidico in tale sindrome. Questa rassegna riassume le evidenze sperimentali sul ruolo del GLP-1 nella regolazione dell’asse sull’asse ipotalamo-ipofisi-ovaio e nei meccanismi patogenetici della PCOS per fornire un razionale al trattamento con GLP-1RA nelle pazienti PCOS normopeso.
Psychological and Physiological Effects of Low-Level Meaningful Artificial Sounds on Intellectual Tasks
Authors: Asakura T. 
Published: September 2023

AbstractThe present study aimed to investigate the psychological and physiological effects of low-level meaningful artificial sounds on intellectual tasks. The psychological factors related to the degree of disturbance, concentration, and stress, as measured by subjective evaluation, were compared with the degree of physiological stress, as measured using salivary alpha-amylase activity. The results indicated that human speech and chewing sounds caused similar levels of psychological stress while performing intellectual tasks; however, chewing sounds caused comparatively less physiological stress than did human speech sounds. These findings suggest that depending on the sound stimulus, psychological and physiological stress characteristics may not coincide.
Private lives: experimental evidence on information completeness in spousal preferences
Authors: Tagat Anirudh , Kapoor Hansika , Kulkarni Savita 
Published: September 2023

AbstractExperimental work using real married couples has shown that efficiency in intra-household allocations is influenced by information asymmetry between spouses. We conduct a lab-in-the-field experiment in rural India to test the extent to which lack of complete information on spousal preferences related to a bundle of private goods can affect allocation dynamics as well as expectations about allocations. We first show that there exist information asymmetries in spousal preferences, and that our information intervention helps reduce gendered misperception in beliefs about allocations and actual allocations, especially for men. However, information on spousal preferences does not significantly affect the final allocation decision, suggesting that husbands and wives may be responding to existing gender norms. We outline implications for experimental work on intra-household bargaining, and for policy.
RETRACTED ARTICLE: Financial Shared Service, Digital Transformation and Corporate Value Creation
Authors: Wang Zujingyang 
Published: September 2023

AbstractThe trend of Chinese enterprises has defied the hard-hit international investment and trade activities of recent years. The scale and globalization of local enterprises continue to develop, and the enterprise management efficiency has become increasingly prominent. This paper delves into the strategic importance of FSSC in augmenting corporate value, and examines the link between digital transformation and the formation of FSSC. The introduction of FSSC and its accompanying digital technology marks a new juncture for corporate reform. Based on RBV and DCV, this paper studies the strategic significance of FSSC to enhance corporate value, and deconstructs the relationship between digital transformation and the development process of financial shared service centers. Based on the time-varying DID, 335 listed companies were selected for a quasi-natural experiment. The results showed that: (1) financial shared service centers can significantly promote the improvement of corporate value. (2) Digital transformation can promote the establishment and development of financial sharing service centers, thus promoting the improvement of corporate value. (3) The effects of FSSC and digital transformation are characterized by heterogeneity. The worth of financial shared service centers for non-state-owned and manufacturing companies is substantial. Digital transformation has a noteworthy positive moderating effect on them but has no considerable moderating effect on state-owned and non-manufacturing companies. The government ought to bolster policy direction, keep up the digital transformation of businesses, and aid them in achieving rapid financial transformation; senior executives should remain cognizant of their strategic position and strive to execute a satisfactory job of both internal and external coordination, as the research findings suggest.
RETRACTED ARTICLE: Effectiveness of Mixed Fuzzy Time Window Multi-objective Allocation in E-Commerce Logistics Distribution Path
Authors: Peng Juanjuan 
Published: September 2023

AbstractThe study of logistics distribution network under e-commerce environment is conducive to the establishment of efficient logistics distribution system, but also to promote the further development of e-commerce and improve social benefits of great significance. This study considers multiple fuzzy factors and introduces a customer fuzzy time window with variable coefficients, establishes a multi-objective set allocation integrated multi-level location path planning model, and proposes an archive type multi-objective simulated annealing improvement algorithm based on master–slave parallel framework embedded taboo search to solve the model. Tabu search and large-scale neighborhood algorithm are used to solve the initial solutions of the first level network and the second level network respectively, and archival reception criterion is introduced to deal with the multi-objective problem. The results of the proposed algorithm for the two-level site-routing problem are less than 6% different from the internationally known optimal solution. The master–slave parallel computing framework improves the efficiency of the algorithm by about 6.38%. The experimental results prove the effectiveness and necessity of the improved optimization. In addition, this study simulates the site-routing problem model constructed by the study by extending the data of standard examples. The experimental results prove the correctness and reference significance of the multilevel site-routing problem model with multiple fuzzy factors.
Alexander the Great or Būrān-Dukht: who is the true hero of theDārāb-nāmaof Ṭarsūsī?
Authors: Gaillard Marina 
Published: September 2023

AbstractThis article presents a new reading of theDārāb-nāma(Book of Dārāb, ca. eleventh–twelfth century), a medieval popular narrative in prose (dāstān) ascribed to the storyteller Abū Ṭāhir Ṭarsūsī. While the narrative belongs to the Persian tradition of the Alexander romance, the Alexander figure it depicts bears little resemblance to that presented in high classical verse-forms by the likes of Firdawsī, Niẓāmī, Amīr Khusraw Dihlavī, or Jāmī. Although still a conqueror, legitimate ruler, and champion of Islam, the Alexander of theDārāb-nāmaappears in a strongly negative light: he is lame, cowardly, and sly. In fact, most of his success he owes to his once opponent and later wife, Būrān-dukht: could she be the true hero in the story? Drawing on a critical examination of characters based on Greimas's actantial model, this study probes the authorial program and intended audience of theDārāb-nāma, and suggests the work can be read as mock-epic, possibly to cater to a Zoroastrian audience.
Seasonal changes in submarine melting mechanisms controlling frontal ablation of Hansbreen, Svalbard
Authors: Ciepły Michał , Ignatiuk Dariusz , Moskalik Mateusz , Jania Jacek , Luks Bartłomiej , Głowacki Oskar , Wojtysiak Kacper 
Published: September 2023

Abstract
We describe the annual pattern of frontal ablation driven by submarine melting mechanisms at the Hansbreen terminus: these are reflected in the intensity and spatial distribution of calving events. Analysis of time-lapse images of the Hansbreen front in conjunction with oceanographic and meteorological data shows that calving intensity is driven primarily by seawater temperature. Regression analysis also highlights the importance of air temperature, which we take to be a proxy for surface ablation and subglacial discharge. This, combined with seasonal changes in ice cliff tortuosity and the increasing significance of wave motion outside the ablation season, enabled us to determine seasonal changes in the mechanisms of ice cliff undercutting by submarine melting. While submarine melting controlled by estuarine circulation primarily drives frontal ablation in summer, wave-driven melting at the waterline is more important outside the ablation season. During winter, ice cliff undercutting by melting is suspended by low seawater temperature, negligible subglacial water discharge and sea-ice cover. The most intense frontal ablation, recorded in summer, was related to higher sea temperature and vigorous estuarine circulation.
Accelerated brain aging as a biomarker for staging in bipolar disorder: an exploratory study
Authors: van der Markt Afra , Klumpers Ursula , Dols Annemiek , Korten Nicole , Boks Marco P. , Ophoff Roel A. , Beekman Aartjan , Kupka Ralph , van Haren Neeltje E. M. , Schnack Hugo 
Published: September 2023

AbstractBackgroundTwo established staging models outline the longitudinal progression in bipolar disorder (BD) based on episode recurrence or inter-episodic functioning. However, underlying neurobiological mechanisms and corresponding biomarkers remain unexplored. This study aimed to investigate if global and (sub)cortical brain structures, along with brain-predicted age difference (brain-PAD) reflect illness progression as conceptualized in these staging models, potentially identifying brain-PAD as a biomarker for BD staging.MethodsIn total, 199 subjects with bipolar-I-disorder and 226 control subjects from the Dutch Bipolar Cohort with a high-quality T1-weighted magnetic resonance imaging scan were analyzed. Global and (sub)cortical brain measures and brain-PAD (the difference between biological and chronological age) were estimated. Associations between individual brain measures and the stages of both staging models were explored.ResultsA higher brain-PAD (higher biological age than chronological age) correlated with an increased likelihood of being in a higher stage of the inter-episodic functioning model, but not in the model based on number of mood episodes. However, after correcting for the confounding factors lithium-use and comorbid anxiety, the association lost significance. Global and (sub)cortical brain measures showed no significant association with the stages.ConclusionsThese results suggest that brain-PAD may be associated with illness progression as defined by impaired inter-episodic functioning. Nevertheless, the significance of this association changed after considering lithium-use and comorbid anxiety disorders. Further research is required to disentangle the intricate relationship between brain-PAD, illness stages, and lithium intake or anxiety disorders. This study provides a foundation for potentially using brain-PAD as a biomarker for illness progression.
Research on “native” and “non-native” English-speaking teachers: Past developments, current status, and future directions
Authors: Selvi Ali Fuad , Yazan Bedrettin , Mahboob Ahmar 
Published: September 2023

AbstractRecently, we have been witnessing the emergence of scholarly interest and professional advocacy efforts centering on systemic, intersectional, fluid, and contextualized inequalities and dynamic hierarchies constructed by essentialized and idealized (non)native speakerhood (speakerism/speakering) and its personal and professional implications for English language teaching (ELT) profession(als). This critical literature review aims to portray, examine, and guide the existing scholarship focusing on a myriad of issues related to ELT professionals traditionally conceptualized as “native” and “non-native” English-speaking teachers. We come to a working conclusion that (non)native speaker/teacherhood is an epistemologically hegemonic, historically colonial, contextually enacted (perceived and/or ascribed), and dynamically experienced socio-professional phenomenon intersecting with other categories of identity (e.g., race, ethnicity, country of origin, gender, religion, sexuality/sexual orientation, social class, schooling, passport/visa status, and physical appearance, among others) in making a priori connections and assertions about individuals as language users and teachers and thereby forming discourses and practices of (in)equity, privilege, marginalization, and discrimination in ELT.
Factors Associated with the Development of High Nutrition Risk: Data from the Canadian Longitudinal Study on Aging
Authors: Mills Christine Marie , Keller Heather H. , DePaul Vincent Gerard , Donnelly Catherine 
Published: September 2023

AbstractThis study aimed to determine which social network, demographic, and health-indicator variables were able to predict the development of high nutrition risk in Canadian adults at midlife and beyond, using data from the Canadian Longitudinal Study on Aging. Multivariable binomial logistic regression was used to examine the predictors of the development of high nutrition risk at follow-up, 3 years after baseline. At baseline, 35.0 per cent of participants were at high nutrition risk and 42.2 per cent were at high risk at follow-up. Lower levels of social support, lower social participation, depression, and poor self-rated healthy aging were associated with the development of high nutrition risk at follow-up. Individuals showing these factors should be screened proactively for nutrition risk.
Factors associated with eating rate: a systematic review and narrative synthesis informed by socio-ecological model
Authors: Chen Yang , Fogel Anna , Bi Yue , Yen Ching Chiuan 
Published: September 2023

AbstractAccumulating evidence shows associations between rapid eating and overweight. Modifying eating rate might be a potential weight management strategy without imposing additional dietary restrictions. A comprehensive understanding of factors associated with eating speed will help with designing effective interventions. The aim of this review was to synthesise the current state of knowledge on the factors associated with eating rate. The socio-ecological model (SEM) was utilised to scaffold the identified factors. A comprehensive literature search of eleven databases was conducted to identify factors associated with eating rate. The 104 studies that met the inclusion criteria were heterogeneous in design and methods of eating rate measurement. We identified thirty-nine factors that were independently linked to eating speed and mapped them onto the individual, social and environmental levels of the SEM. The majority of the reported factors pertained to the individual characteristics (n = 20) including demographics, cognitive/psychological factors and habitual food oral processing behaviours. Social factors (n = 11) included eating companions, social and cultural norms, and family structure. Environmental factors (n = 8) included food texture and presentation, methods of consumption or background sounds. Measures of body weight, food form and characteristics, food oral processing behaviours and gender, age and ethnicity were the most researched and consistent factors associated with eating rate. A number of other novel and underresearched factors emerged, but these require replication and further research. We highlight directions for further research in this space and potential evidence-based candidates for interventions targeting eating rate.
The Estimated Climate Impact of the Hunga Tonga‐Hunga Ha'apai Eruption Plume
Authors: Schoeberl M. R. , Wang Y. , Ueyama R. , Dessler A. , Taha G. , Yu W. 
Published: September 2023

AbstractOn 15 January 2022, the Hunga Tonga‐Hunga Ha'apai (HT) eruption injected SO2 and water into the middle stratosphere. The SO2 is rapidly converted to sulfate aerosols. The aerosol and water vapor anomalies have persisted in the Southern Hemisphere throughout 2022. The water vapor anomaly increases the net downward IR radiative flux whereas the aerosol layer reduces the direct solar forcing. The direct solar flux reduction is larger than the increased IR flux. Thus, the net tropospheric forcing will be negative. The changes in radiative forcing peak in July and August and diminish thereafter. Scaling to the observed cooling after the 1991 Pinatubo eruption, HT would cool the 2022 Southern Hemisphere's average surface temperatures by less than 0.037°C.
Magnesium Isotope Variations in Granite Regoliths From Two Contrasting Climates
Authors: Gao Ting , Qi Meng , Wang Zhengrong , Yin Runsheng , Liu Chengshuai , Liu Yuhui , Ke Shan , Zhao Zhi‐Qi 
Published: September 2023

AbstractMagnesium (Mg) isotopes have been utilized to constrain continental weathering; however, to date, little is known about the climate effects on Mg isotope fractionation during weathering. In this study, we measured δ26Mg values of bulk regolith and exchangeable fraction in two granite regolith profiles developed under temperate, semiarid and tropical, humid climate conditions, respectively. Combined with mineralogy and element composition, we aimed to investigate how climate influences fractionation patterns of Mg isotopes during chemical weathering. At the temperate site, δ26Mg values of regolith are slightly higher than that of the bedrock and negatively correlated with τMg,Th. Correspondingly, the exchangeable Mg is characterized by low δ26Mg values. These results can be explained by the formation of small number of clay minerals. For the tropical regolith profile, δ26Mg values decrease toward the surface, and the regolith has either lower δ26Mg values above −250 cm or higher δ26Mg values below −250 cm relative to the bedrock. The δ26Mg value of exchangeable Mg is markedly lower than that of the regolith and varies significantly. These results can be explained by the mixing of Mg from solid weathering products and atmospheric deposition. The Mg from rainwater and/or marine aerosol deposit on the regolith and some may enter the crystal structure of the illite. The deposited Mg can overprint the granitic Mg, and the δ26Mg value of shallow regolith samples will reflect mixing between granitic and atmospheric sources. The compilation of our and previously published Mg isotopic data reveals the potential control of climate on Mg isotope fractionation during continental weathering.
New Index to Characterize Ionospheric Irregularity Distribution
Authors: Yizengaw Endawoke 
Published: September 2023

AbstractCharacterization of the global ionospheric irregularities as a function of local time, longitude, altitude, and magnetic activities is still a challenge for radio frequency operations, especially at the low‐latitude region. One of the main reasons is lack of observations due to the unevenly distributed instruments. To overcome this constraint, we developed a new spatial density gradient index (DGRI) at two different scale sizes: small scale and medium/large scale. The DGRI is derived from in situ density measurements onboard recently launched constellation of low‐Earth‐orbiting satellites (COSMIC‐2 and ICON) at the rate of 1 Hz. Hence, the DGRI appeared to be suitable parameter that can be used as a proxy to describe the essential features of ionospheric disturbances that may critically affect our radio wave application as well as to identify the “all clear” zone as a function of longitude, latitude, and local time—at a refreshment rate of 30 min or less.
Patient-specific models link neurotransmitter receptor mechanisms with motor and visuospatial axes of Parkinson’s disease
Authors: Khan Ahmed Faraz , Adewale Quadri , Lin Sue-Jin , Baumeister Tobias R. , Zeighami Yashar , Carbonell Felix , Palomero-Gallagher Nicola , Iturria-Medina Yasser 
Published: September 2023

AbstractParkinson’s disease involves multiple neurotransmitter systems beyond the classical dopaminergic circuit, but their influence on structural and functional alterations is not well understood. Here, we use patient-specific causal brain modeling to identify latent neurotransmitter receptor-mediated mechanisms contributing to Parkinson’s disease progression. Combining the spatial distribution of 15 receptors from post-mortem autoradiography with 6 neuroimaging-derived pathological factors, we detect a diverse set of receptors influencing gray matter atrophy, functional activity dysregulation, microstructural degeneration, and dendrite and dopaminergic transporter loss. Inter-individual variability in receptor mechanisms correlates with symptom severity along two distinct axes, representing motor and psychomotor symptoms with large GABAergic and glutamatergic contributions, and cholinergically-dominant visuospatial, psychiatric and memory dysfunction. Our work demonstrates that receptor architecture helps explain multi-factorial brain re-organization, and suggests that distinct, co-existing receptor-mediated processes underlie Parkinson’s disease.