bluuebunny/crossref_metadata_2025_split huggingface dataset:
The anatomy of a bubble company: The London Assurance in 1720
Authors: Acheson Graeme , Aldous Michael , Quinn William 
Published: May 2023

AbstractThe London Assurance Company (LA), which incorporated during the bubble of 1720, experienced more dramatic price movements in its shares than the South Sea Company. This paper examines how incorporating during the bubble affected its long run performance. We show that the bubble in the Company's share price was partly attributable to changes in market structure during the share issuance process. As a result of the bubble, the Company's original subscribers, who had been curated for expertise and political connections, overwhelmingly exited during 1720 and were replaced by unsuccessful speculators. Analysis of LA shareholder behaviour up to 1737 suggests that this loss of shareholder expertise had detrimental consequences for the Company's performance. These results demonstrate how a bubble in the shares of a newly created company can lead to an exodus of value‐adding investors, damaging the company's long‐term prospects.
Female great tits (Parus major) reproduce earlier when paired with a male they prefer
Authors: Delaitre Ségolène , van Oers Kees , Visser Marcel E. , Caro Samuel P. 
Published: May 2023

AbstractMate choice is a key component of reproductive biology. Females often prefer certain males but do females modulate their reproductive investment depending on whether they are mated with their preferred partner? We investigated this question in great tits (Parus major) where we subjected 36 females to a six‐choice mate preference test. Male morphological traits and the female's own characteristics did not influence the preference females expressed. We however found that females spent more time near more exploratory males. We then paired females with one of the males in indoor aviaries, and subsequently monitored their reproductive investment (through measurement of plasma 17β‐oestradiol concentrations, first egg date, clutch size and egg size). Females that were mated with a male for which they had a strong preference laid their first clutch significantly earlier in the season than females paired with a male they less preferred. Our results show that mate preference influences reproductive investment in great tits, thereby linking mate choice to bird reproductive decisions.
Nocturnal parental care and the role of parents in hatching their eggs in the clown anemonefish
Authors: Pacaro Madison , Barbasch Tina , Rogers Michaela , Chavez Juan , Buston Peter , Majoris John 
Published: May 2023

AbstractParental care is a critical component of many breeding systems that enhances both parent and offspring fitness. It is widely recognized that parental care varies in quality and quantity in response to variation in offspring need, parental condition, and ecological context. One context that has been underexplored, however, is the presence of extensive parental care at night, with many parental care studies focused on diurnal care. To fully understand the evolution of parental care, both diurnal and nocturnal care must be accounted for. Here, we show that nocturnal parental care exists in the clownfish Amphiprion percula, with males and females actively caring for offspring at night throughout embryo development and during hatching within a laboratory setting. At night, as during the day, males continue to be the dominant caregiver and both parents increase care as embryos mature. However, females provide substantially more care at night than during the day. We also document three new parental care behaviors at night that are not seen during the day: vigorous fanning, vigorous mouthing, and anemone biting. These behaviors are particularly frequent during hatching, and they may serve to assist the hatching process by helping embryos transition from the benthic to the pelagic environment. This study contributes to our understanding of parental care, demonstrating the importance of considering nocturnal care if we are to gain a complete understanding of the evolution of parental care.
ASYv3: Attention‐enabled pooling embedded Swin transformer‐based YOLOv3 for obscenity detection
Authors: Samal Sonali , Zhang Yu‐Dong , Gadekallu Thippa Reddy , Balabantaray Bunil Kumar 
Published: May 2023

AbstractThe rampant spread of explicit content across social media can leave a damaging mark on our society. Hence, the need to be vigilant in detecting and curtailing sexually explicit content cannot be overstated. As such, it becomes paramount to discern and manage sexually explicit material to curb its dissemination and safeguard our digital communities from its harmful effects. In this article, we propose a unique technique entitled attention‐enabled pooling (ABP) embedded Swin transformer‐based YOLOv3 (ASYv3) for the detection of obscene areas present in the images with a bounding box around the offensive regions. ASYv3 employs a unique two‐step approach for enhanced performance in obscene detection. In the first step, a scalable and efficient Swin transformer block is integrated, utilizing self‐attention and model parallelism to train massive models effectively. In the second phase, the embedding layer of the Swin transformer is replaced with ABP, mitigating disruption of feature context. ABP allows for the projection of raw‐valued features into linear form with proper attention to feature context information at specified locations, resulting in optimized feature extraction. The proposed ABP embedded Swin transformer‐based YOLOv3 (ASYv3) was trained with annotated obscene images (AOI) dataset. The proposed ASYv3 model surpassed the state‐of‐the‐art methods by achieving 97% testing accuracy, 96.62% precision, 97.40% sensitivity, 3.48% FPR rate, 97.37% NPV values, and 95.59% mAP values, respectively.
Tandem and inverted duplications in haemophilia A: Breakpoint characterisation provides insight into possible rearrangement mechanisms
Authors: Li Yang , Ding Biying , Mao Yinqi , Zhang Huayang , Wang Xuefeng , Ding Qiulan 
Published: May 2023

AbstractIntroductionApproximately half of patients with severe haemophilia A are caused by structural variants in the F8 gene. Unlike inversions or deletions directly impairing the integrity of F8, some duplications do not completely disrupt the open reading frame or even retain an intact F8 copy. Currently, only a few duplication breakpoints were precisely characterized, and the corresponding rearrangement mechanisms and clinical outcomes remain to be further investigated.AimEstablishing an effective strategy for breakpoint characterization of duplications and revealing their rearrangement mechanisms.MethodsAccuCopy is used for the detection of duplications, long‐distance PCR for the characterization of tandem duplications, genome walking technique and whole genome sequencing for the characterization of inverted duplications.ResultsFour F8 duplication rearrangements were successfully characterized at the nucleotide level: one tandem duplication (exons 7–11) and three inverted duplications (exons 7–22, exons 2–26, and exons 15–22). Two shared features of inverted duplication were found after carefully analysing our results and breakpoint information in the literature: 1, an inverted fragment was inserted into the original chromosome via two junctions; 2, one junction is mediated by a pair of inverted repetitive elements, while the other consists of two breakpoints with microhomology.ConclusionSimilar breakpoint features motivated us to propose a DNA replication‐based model to explain the formation of duplication rearrangements. Based on our model, we further divide the inverted duplications into three basic types: type I with a DEL‐NOR/INV‐DUP pattern, type II with a DUP‐NOR/INV‐DUP pattern and type III with a DUP‐TRP/INV‐DUP pattern.
META‐ANALYSIS OF STUDIES USING SELECTIVE α1‐BLOCKERS IN PATIENTS WITH HYPERTENSION AND TYPE 2 DIABETES
Authors: Glanz M , Garber AJ , Mancia G , Levenstein M 
Published: May 2023

SUMMARYThis meta‐analysis of published studies evaluated the effect of selective α1‐blockers on lipid and carbohydrate profiles and blood pressure (BP) as well as tolerability in patients with hypertension and type 2 diabetes. Publications identified via MEDLINE were used. Text and bibliographies of retrieved articles were examined for additional references. Clinical trials with a randomised comparative structure (placebo and active treatment arms) and controlled studies with other structures were included. Of the 27 citations identified, 22 studies were selected for inclusion, and five were rejected. Efficacy and safety data, lipid and carbohydrate profiles, and study and patient characteristics were extracted by two investigators independently. The mean pooled results showed beneficial effects of selective α1‐blockers on total serum cholesterol (TC), high‐density lipoprotein (HDL) cholesterol, and systolic and diastolic BP. The results also showed doxazosin had beneficial effects on fasting glucose levels, insulin sensitivity, TC, HDL cholesterol, low‐density lipoprotein (LDL) cholesterol, HDL/TC ratio, and systolic and diastolic BP. The risk difference was equivalent between the α1‐blocker group and the control group for postural hypotension or syncope. This meta‐analysis demonstrates a number of favourable effects of therapy with selective α1‐blockers in hypertensive patients with type 2 diabetes. These agents provide an effective modality for reducing BR with favourable effects on lipid, no deterioration in glycaemic control, and little risk of orthostatic hypotension.
INFLAMMATORY PSEUDOTUMOUR OF THE LIVER ASSOCIATED WITH DIABETES MELLITUS
Authors: Younis N , Khaleeli AA , Soran H , Monteith PG 
Published: May 2023

SUMMARYInflammatory pseudotumours of the liver are rare benign tumours of unknown origin, usually mistaken for malignant lesions. Two patients with Type 2 diabetes presented separately, unwell with fever, weight loss and hepatomegaly. Ultrasonography revealed 3–4 cm multiple lesions in the liver of the first case and a solitary 5 cm mass in the right lobe of the liver in the second. Biopsies revealed inflammatory pseudotumours in both cases. Both patients were treated with intravenous antibiotics and fluids. The clinical outcome was good and both patients had an uneventful recovery. We believe these to be the first two cases of inflammatory liver pseudotumours to be described in patients with diabetes mellitus.
Caregivers' perspectives on future planning for their adult children with intellectual disabilities in Romania
Authors: Ion Sandica , Lightfoot Elizabeth 
Published: May 2023

AbstractBackgroundMuch of the research and program innovation regarding future planning for adults with intellectual disabilities has occurred in countries with well‐developed disability service systems. This study explored how family caregivers planned for their adult children's future caregiving needs in Romania, a country with a limited array of disability services.MethodIn this exploratory qualitative study, we conducted 30 face‐to‐face interviews with caregivers of adults with intellectual disabilities in Romania. We used thematic analysis to analyse the transcribed and translated interview data.ResultsThe majority of participants, while believing that future planning was necessary, had not engaged in planning and had no supports for planning. As there were few disability services, the majority of the participants reported that they could not engage in planning, and many avoided thinking about the future.ConclusionRomania and other countries with fewer disability services likely need alternative models of future planning than those that have been developed and tested previously.
Bolsonaro's government and the dismantling of the participative institutions in environmental policy
Authors: Seifert Carlos Alberto , de Queiroz‐Stein Guilherme , Gugliano Alfredo Alejandro 
Published: May 2023

AbstractIn 2018, Jair Bolsonaro won the Brazilian presidential election with the political support of conservative groups and large business groups that aimed to intensify a neo‐extractivist model of economic growth, leading to severe environmental damage. This article analyzes the first years of this government to understand how conservative neo‐populism associates economic growth strategies with brusque changes regarding the environment. We have identified the main measures adopted in the environmental arena, observing changes in the legislation, management bodies, and spaces available for civil society participation. This analysis demonstrates how Bolsonaro's government destroyed the institutional bases established during Brazilian redemocratization to intensify the neo‐extractivism model and gratify its supporters. Furthermore, we discuss how this dismantling of environmental governance implies grave consequences for the ecosystems, indigenous people, and other traditional populations.
Asymptotic subadditivity/superadditivity of Value‐at‐Risk under tail dependence
Authors: Zhu Wenhao , Li Lujun , Yang Jingping , Xie Jiehua , Sun Liulei 
Published: May 2023

AbstractThis paper presents a new method for discussing the asymptotic subadditivity/superadditivity of Value‐at‐Risk (VaR) for multiple risks. We consider the asymptotic subadditivity and superadditivity properties of VaR for multiple risks whose copula admits a stable tail dependence function (STDF). For the purpose, a marginal region is defined by the marginal distributions of the multiple risks, and a stochastic order named tail concave order is presented for comparing individual tail risks. We prove that asymptotic subadditivity of VaR holds when individual risks are smaller than regularly varying (RV) random variables with index −1 under the tail concave order. We also provide sufficient conditions for VaR being asymptotically superadditive. For two multiple risks sharing the same copula function and satisfying the tail concave order, a comparison result on the asymptotic subadditivity/superadditivity of VaR is given. Asymptotic diversification ratios for RV and log regularly varying (LRV) margins with specific copula structures are obtained. Empirical analysis on financial data is provided for highlighting our results.
Elevation provenance affects photosynthesis and its acclimation to temperature in the high‐Andes alpine herb Phacelia secunda
Authors: Hernández‐Fuentes C. , Galmés J. , Bravo L. A. , Cavieres L. A. 
Published: May 2023

Abstract

We analysed whether Phacelia secunda populations from different elevations exhibit intrinsic traits associated with diffusive and biochemical components of photosynthesis, and if they differ in acclimation of photosynthesis to warmer temperatures. We hypothesized that P. secunda will have similar photosynthetic performance regardless of altitudinal provenance and that plants from high elevations will have a lower photosynthetic acclimation capacity to higher temperature than plants from low elevations.

Plants from 1600, 2800 and 3600 m a.s.l. in the central Chilean Andes were collected and grown under two temperature regimes (20/16 °C and 30/26 °C day/night). The following photosynthetic traits were measured in each plant for the two temperature regimes: AN, gs, gm, Jmax, Vcmax, Rubisco carboxylation kcatc.

Under a common growth environment, plants from the highest elevation had slightly lower CO2 assimilation rates compared to lower elevation plants. While diffusive components of photosynthesis increased with elevation provenance, the biochemical component decreased, suggesting compensation that explains the similar rates of photosynthesis among elevation provenances. Plants from high elevations had lower photosynthetic acclimation to warmer temperatures compared to plants from lower elevations, and these responses were related to elevational changes in diffusional and biochemical components of photosynthesis.

Plants of P. secunda from different elevations maintain photosynthetic traits when grown in a common environment, suggesting low plasticity to respond to future climate changes. The fact that high elevation plants had lower photosynthetic acclimation to warmer temperature suggests higher susceptibility to increases in temperature associated with global warming.
Orthogonal contrasts for both balanced and unbalanced designs and both ordered and unordered treatments
Authors: Rayner J. C. W. , Livingston G. C. 
Published: May 2023

AbstractWe consider designs with t treatments, the ith level of which has ni observations. Four cases are examined: treatment levels both ordered and not, and the design balanced, with all ni equal, and not. A general construction is given that takes observations, typically treatment sums or treatment rank sums, constructs a simple quadratic form and expresses it as a sum of squares of orthogonal contrasts. For the case of ordered treatment levels, the Kruskal–Wallis, Friedman and Durbin tests are recovered by this construction. A dataset where the design is the supplemented balanced, which is an unbalanced design in our terminology, is analyzed. When treatment levels are not ordered the construction also applies. We then focus on Helmert contrasts.
Characterization of the conserved features of the NSE6 subunit of the Physcomitrium patens SMC5/6 complex
Authors: Lelkes Edit , Jemelková Jitka , Holá Marcela , Štefanovie Barbora , Kolesár Peter , Vágnerová Radka , Dvořák Tomaštíková Eva , Pecinka Ales , Angelis Karel J. , Paleček Jan J. 
Published: May 2023

SUMMARYStructural maintenance of chromosomes (SMC) complexes are molecular machines ensuring chromatin organization at higher levels. They play direct roles in cohesion, condensation, replication, transcription, and DNA repair. Their cores are composed of long‐armed SMC, kleisin, and kleisin‐associated subunits. Additional factors, like NSE6 within SMC5/6, bind to SMC core complexes and regulate their activities. In the human HsNSE6/SLF2, we recently identified a new CANIN domain. Here we tracked down its sequence homology to lower plants, selected the bryophyte Physcomitrium patens, and analyzed PpNSE6 protein–protein interactions to explore its conservation in detail. We identified a previously unrecognized core sequence motif conserved from yeasts to humans within the NSE6 CANIN domain. This motif mediates the interaction between NSE6 and its NSE5 partner in yeasts and plants. In addition, the CANIN domain and its preceding PpNSE6 sequences bind both PpSMC5 and PpSMC6 arms. Interestingly, we mapped the PpNSE6‐binding site at the PpSMC5 arm right next to the PpNSE2‐binding surface. The position of NSE6 at SMC arms suggests its role in the regulation of SMC5/6 dynamics. Consistent with the regulatory role of NSE6 subunits, Ppnse6 mutant lines were viable and sensitive to the DNA‐damaging drug bleomycin and lost a large portion of rDNA copies. These moss mutants also exhibited reduced growth and developmental aberrations. Altogether, our data showed the conserved function of the NSE6 subunit and architecture of the SMC5/6 complex across species.
Impedance Sensitivity Analysis Based on Discontinuous Isogeometric Boundary Element Method in Automotive Acoustics
Authors: Sun Yi , Liping Xie , Lu Chihua , Liu Zhien , Chen Wan , Li Xiaolong 
Published: May 2023

Abstract
Acoustic sensitivity analysis is an essential technique to determine the direction of structural-acoustic optimization by evaluating the gradient of the objective functions with respect to the design variables. However, acoustic sensitivity analysis with respect to acoustic impedance, which is an important parameter representing the interior absorbent material in automotive acoustics, is lacking in the study. Moreover, acoustic sensitivity analysis implemented with conventional numerical methods is time and effort-consuming in automotive acoustics, due to the large-scale mesh generation. In this work, the impedance sensitivity analysis for automotive acoustics based on the discontinuous isogeometric boundary element method is presented. The regularized boundary integral equation with impedance boundary conditions is established, then the sensitivity is derived by differentiating the boundary integral equation. The efficiency of the proposed method is improved by employing the parallel technique and generalized minimal residual solver. A long duct example with an analytical solution validates the accuracy of the proposed method, and an automotive passenger compartment subjecting to impedance boundary conditions illustrates that the computing time of the proposed method is one order of magnitude less than the conventional method. This work presents an easily implementable and efficient tool to investigate acoustic sensitivity with respect to impedance, showing great potential in the application of automotive acoustics.
Performance Optimization of Finned Surfaces Based on the Experimental and Numerical Study
Authors: Kocak Eyup , Turkoglu Hasmet , Aylı Ece 
Published: May 2023

Abstract
This paper presents the findings of numerical and experimental investigations into the forced convection heat transfer from horizontal surfaces with straight rectangular fins at Reynolds numbers ranging from 23,600 to 150,000. A test setup was constructed to measure the heat transfer rate from a horizontal surface with a constant number of fins, fin width, and fin length under different flow conditions. Two-dimensional numerical analyses were performed to observe the heat transfer and flow behavior using a computer program developed based on the openfoam platform. The code developed was verified by comparing the numerical results with the experimental results. The effect of geometrical parameters on heat transfer coefficient and Nusselt number was investigated for different fin height and width ratios. Results showed that heat transfer can be increased by modifying the fin structure geometrical parameters. A correlation for Nusselt number was developed and presented for steady-state, turbulent flows over rectangular fin arrays, taking into account varying Prandtl number of fluids such as water liquid, water vapor, CO2, CH4, and air. The correlation developed predicts the Nusselt number with a relative root mean square error of 0.36%. This research provides valuable insights into the effects of varying Prandtl numbers on the efficiency of forced convection cooling and will help in the design and operation of cooling systems. This study is novel in its approach as it takes into account the effect of varying Prandtl numbers on the heat transfer coefficient and Nusselt number and provides a correlation for the same. It will serve as a valuable reference for engineers and designers while designing and operating cooling systems.