bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and implementation of an electronic opioid management plan to support consistent communication of opioid analgesia prescribing intentions to patients and general practitioners
Authors: Su Elizabeth , Aminian Parnaz , McMaster Christopher , Eyles Jade , Frauman Albert G. , Garrett Kent , Taylor Simone E. , Liew David F. L. 
Published: June 2023

AbstractOpioid prescribing requires careful planning to minimise the risk of serious adverse outcomes. However, documentation of discharge opioid plans for patients and their general practitioners (GPs) is inconsistent, particularly when opioids are commenced in the emergency department or after surgery. We describe an initiative to promote consistent discharge opioid plan communication by implementing an opioid management plan (OMP) in our hospital's electronic medical record. Completion of an electronic form by the prescriber generates an OMP note in the medical history, which is used by the pharmacist to provide tailored opioid patient education. The OMP also populates the discharge summary that is sent to the GP and the Australian national digital health record platform, My Health Record. Preliminary evaluation shows incorporating OMP documentation into routine workflows has assisted prescribers to consistently document the plan for supplied opioids, supporting continuity of care. Workflow optimisation is ongoing to further improve discharge summary documentation and provision of patient‐friendly written information. This study was conducted as a quality improvement project and audits conducted as part of the project were approved by Austin Health's Office for Research (Project No: LNR/18/Austin/155). Informed patient consent was not required by Austin Health.
Polyoxyethylene glycol ethers of fatty alcohols used in cloud point extraction of Viola tricolor: Polyphenols solubilization, antioxidant activity studies and molecular dynamic simulations
Authors: Śliwa Paweł , Śliwa Karolina 
Published: June 2023

AbstractThe following paper proposes a modern method of obtaining an extract from Viola tricolor L. with a high rutin content and enhanced antioxidant activity. Conventional isolation of active substances from plant raw material is high‐cost, elaborate and often harmful to the environment. The ultrasonic assistance micelle‐mediated extraction method (UAMME) and the cloud‐point extraction/separation technique are interesting alternatives. This work discusses the relationship between salt concentration and the cloud‐point extraction (CPE) yield. The molecular dynamic simulations investigated the impact of hydrocarbon chain length and the ratio of oxyethylene/oxypropylene units of model surfactants on the interactions between extraction system components. Micellar extract from the Viola tricolor was obtained using C9‐11 Pareth‐5 at 1 wt/vol% and subsequently concentrated by CPE with the addition of NaCl in concentrations from 5% to 30%. For comparison, water and ethanol extracts were also prepared. Antioxidant properties, polyphenols and flavonoid contents were measured for all samples. The HPLC method was used to determine the rutin concentration. The simulation part of the study confirmed the dependence of bioflavonoid solubilization efficiency on the surfactant structure. The determined descriptors allowed for finding the optimal structure of the model surfactants and gave a hint for their application to obtain extracts with high concentrations of antioxidants.
Cervical facet capsular ligament mechanics: Estimations based on subject‐specific anatomy and kinematics
Authors: Nikpasand Maryam , Abbott Rebecca E. , Kage Craig C. , Singh Sagar , Winkelstein Beth A. , Barocas Victor H. , Ellingson Arin M. 
Published: June 2023

AbstractBackgroundTo understand the facet capsular ligament's (FCL) role in cervical spine mechanics, the interactions between the FCL and other spinal components must be examined. One approach is to develop a subject‐specific finite element (FE) model of the lower cervical spine, simulating the motion segments and their components' behaviors under physiological loading conditions. This approach can be particularly attractive when a patient's anatomical and kinematic data are available.MethodsWe developed and demonstrated methodology to create 3D subject‐specific models of the lower cervical spine, with a focus on facet capsular ligament biomechanics. Displacement‐controlled boundary conditions were applied to the vertebrae using kinematics extracted from biplane videoradiography during planar head motions, including axial rotation, lateral bending, and flexion–extension. The FCL geometries were generated by fitting a surface over the estimated ligament–bone attachment regions. The fiber structure and material characteristics of the ligament tissue were extracted from available human cervical FCL data. The method was demonstrated by application to the cervical geometry and kinematics of a healthy 23‐year‐old female subject.ResultsFCL strain within the resulting subject‐specific model were subsequently compared to models with generic: (1) geometry, (2) kinematics, and (3) material properties to assess the effect of model specificity. Asymmetry in both the kinematics and the anatomy led to asymmetry in strain fields, highlighting the importance of patient‐specific models. We also found that the calculated strain field was largely independent of constitutive model and driven by vertebrae morphology and motion, but the stress field showed more constitutive‐equation‐dependence, as would be expected given the highly constrained motion of cervical FCLs.ConclusionsThe current study provides a methodology to create a subject‐specific model of the cervical spine that can be used to investigate various clinical questions by coupling experimental kinematics with multiscale computational models.
Low carbon accumulation in a macro‐tidal mangrove forest on the Amazon coast
Authors: Passos Tiago , Bernardino Angelo F. , Penny Dan , Barcellos Roberto , Passos Francisco U. , Nobrega Gabriel N. , Ferreira Tiago O. , Kauffman J. Boone , Sanders Christian J. 
Published: June 2023

AbstractThe important role mangrove forests play in sequestering organic carbon is well known, yet rates of organic carbon accumulation in macro‐tidal mangrove ecosystems are poorly resolved. Here we use 210Pb dating to present a 125‐yr record of carbon, nutrient and trace metal accumulation in sediments from an Amazon macro‐tidal mangrove forest. We find that the rate of organic carbon accumulation ranged from 23.7 to 74.7 g m−2 yr−1 (average 38 ± 13.5 g m−2 yr−1), significantly lower than global averages for mangrove forests. These low rates may be associated with sediment grain‐size and sediment–water interface processes that drive organic matter oxidation and reduce carbon stocks in these highly dynamic macro‐tidal forests. Total nitrogen accumulation ranged from 1.4 to 5.1 g m−2 yr−1 (average 2.7 ± 0.9 g m−2 yr−1) and phosphorus from 1.5 to 8.4 g m−2 yr−1(average 4.3 ± 1.9 g m−2 yr−1). Trace metal accumulation rates (As, Pb, Cr, Cu, Mn, Ni, Zn, Hg, Bo, V, Co, Mo, S, and Ba) were also lower than other tropical mangrove forests globally, but trace metal in more recent sediments for Mn, As, Cu, and Hg were elevated, likely reflecting human footprint in the region since early the 20th century. The ability to accurately quantify carbon accumulation rates in mangrove ecosystems is critical for climate change mitigation strategies and the implementation of carbon offset schemes globally.
Polymeric Nanoformulation of Zoledronic Acid Rescues Osteoblasts from the Harmful Effect of its Native Form: An In Vitro Investigation of Cytotoxic Potential on Osteoblasts and Osteosarcoma Cells
Authors: Dash Pratigyan , Samal Sasmita , Prasad Panda Gyanendra , Piras Anna Maria , Dash Mamoni 
Published: June 2023

AbstractOsteosarcoma (OS) is a malignant tumor, fatal for pediatric patients who do not respond to chemotherapy, alternative therapies and drugs can provide better outcomes. Zoledronic acid (Zol) belonging to the class of bisphosphonates (BPs) has a direct antitumor ability to prevent Ras GTPases modification and stimulate apoptosis. Despite advances in maintaining balance in skeletal events and direct anticancer properties, Zol causes cytotoxicity to normal healthy pre‐osteoblast cells, hampering mineralization and differentiation. The study reports the preparation and evaluation of a nanoformulation that can diminish the existing drawbacks of native Zol. The cytotoxic effect is evaluated on bone cancer cells and healthy bone cells with three different cell lines namely, K7M2 (mouse OS cell line), SaOS2 (human OS cell line), and MC3T3E1 (healthy cell counterpart). It is observed that Zol nanoformulation is uptaken more (95%) in K7M2 whereas in MC3T3E1, the percent population internalizing nanoparticles (NPs) is 45%. Zol has a sustained release of 15% after 96 h from the NP which leads to a rescuing effect on the normal pre‐osteoblast cells. In conclusion, it can be stated that Zol nanoformulation can be used as a good platform for a sustained release system with minimum side effects to normal bone cells.
Bilanzen: Das Ende der Coronapandemie in Verkaufszahlen
Authors: Zbikowski Frauke 
Published: June 2023

AbstractDie deutschen Laborzulieferer erzielten im letzten Jahr erstmals einen Umsatz von über elf Milliarden Euro. Die Zahlen sind allerdings durch die Inflation verzerrt. Zurück gingen die Umsätze mit Verbrauchsmaterialien wie Pipettenspitzen und Materialien für die medizinische Diagnostik.
Chemie in der Schule: Fachfremd unterrichten
Authors: Rautenstrauch Hanne , Busker Maike 
Published: June 2023

AbstractFür das Schulfach Chemie gibt es nicht genug qualifizierte Lehrkräfte. Die Schulen setzen deswegen oft Lehrkräfte ein, die gar nicht Chemie studiert haben. Doch wie stehen fachfremd Unterrichtende zum Experimentieren im Unterricht? Setzen sie Experimente ein? Und welche Schwierigkeiten sehen sie dabei? Lehrerinnen und Lehrer aus Schleswig‐Holstein haben auf diese Fragen geantwortet.
Metall‐Ligand‐Kooperativität: Gemeinsam stärker
Authors: Hadlington Terrance 
Published: June 2023

AbstractTerrance Hadlington stellt das etablierte Konzept der Metall‐Ligand‐Kooperativität auf den Kopf und sucht nach Systemen, die eine Hydroaminierung von Alkenen mit Ammoniak erreichen können.
Analytical solutions for a fully coupled hydraulic‐mechanical‐chemical model with non‐zero initial concentration of contaminant
Authors: Han Lin , Zhang Zhihong 
Published: June 2023

AbstractAnalytical solutions for coupled problems are very significant for both understanding the physical mechanism and verifying the numerical methods. However, existing solutions usually focus on advection‐dispersion models without considering the coupling effect of contaminant transport or partial‐coupled models with the zero initial concentration (ZIC) condition, which are impractical in many engineering applications. This paper proposes novel analytical solutions to solve the non‐zero initial concentration (NZIC) problem for a fully‐coupled hydraulic‐mechanical‐chemical (HMC) model by Fourier transform. The proposed analytical solutions are highly competent and efficient compared with existing solutions from the literature. The solutions are applied to investigate the long‐term contaminant transport behavior and consequent deformation of clay liner under NZIC conditions. Results show that the presence of NZIC greatly promotes contaminant ions migration and shorten breakthrough time. The higher the initial concentration, the shorter the breakthrough time. When the initial concentration is increased by 3 and 5 times, the corresponding breakthrough time is reduced by 23.9 and 27.1 years, respectively. In practical engineering, neglecting the NZIC of contaminant can lead to an overestimation of performance efficiency of clay liners.
A highly accurate artificial neural networks scheme for solving higher multi‐order fractal‐fractional differential equations based on generalized Caputo derivative
Authors: Shloof A. M. , Ahmadian A. , Senu N. , Salahshour Soheil , Ibrahim S. N. I. , Pakdaman M. 
Published: June 2023

AbstractArtificial neural networks have great potential for learning and stability in the face of tiny input data changes. As a result, artificial intelligence techniques and modeling tools have a growing variety of applications. To estimate a solution for fractal‐fractional differential equations (FFDEs) of high‐order linear (HOL) with variable coefficients, an iterative methodology based on a mix of a power series method and a neural network approach was applied in this study. In the algorithm's equation, an appropriate truncated series of the solution functions was replaced. To tackle the issue, this study uses a series expansion of an unidentified function, where this function is approximated using a neural architecture. Some examples were presented to illustrate the efficiency and usefulness of this technique to prove the concept's applicability. The proposed methodology was found to be very accurate when compared to other available traditional procedures. To determine the approximate solution to FFDEs‐HOL, the suggested technique is simple, highly efficient, and resilient.
Effectiveness of differentiated instruction on learning outcomes and learning satisfaction in the evidence‐based nursing course: Empirical research quantitative
Authors: Liou Shwu‐Ru , Cheng Ching‐Yu , Chu Tsui‐Ping , Chang Chia‐Hao , Liu Hsiu‐Chen 
Published: June 2023

AbstractAimDiversified students in higher education and the complexity and difficulty of the evidence‐based nursing course perceived by students challenge nursing educators. Differentiated instruction can provide students with various opportunities to learn and meet the learning needs of students with different academic abilities and strengths, which may be a solution. This study aimed to apply differentiated instruction to design the undergraduate evidence‐based nursing course and evaluate the effects of differentiated instruction on students' learning outcomes and learning satisfaction.DesignOne‐group pretest–posttest pre‐experimental design was applied.MethodsNinety‐eight undergraduate nursing students enrolled in the evidence‐based nursing course 2020 participated in this study. Students' learning outcomes including preferred learning styles, classroom engagement, collaborative learning, attitudes towards evidence‐based nursing, learning satisfaction and evidence‐based nursing knowledge were measured using validated questionnaires.ResultsThe differentiated instruction increased students' learning interests, promoted focused and independent thinking, and enhanced academic achievement. Students' classroom engagement, attitudes towards evidence‐based nursing, evidence‐based nursing knowledge and learning satisfaction were improved after the course. The course designed with differentiated instruction provided a supportive learning environment and furnished a vivid pedagogical way for the unique nursing profession.Patient or Public ContributionPositive results of the study support the application of differentiated instruction in the evidence‐based nursing course. The study indicates that the application of differentiated instruction in mixed‐ability classrooms in the evidence‐based nursing course improved students' learning outcomes, attitudes towards evidence‐based nursing, evidence‐based nursing knowledge and learning satisfaction. In clinical settings where nurses are even more diverse in academic education, clinical experiences and learning preferences, differentiated instruction can be a suitable application for in‐service training and education to promote nurses' enthusiasm for professional learning.
Consensus classification of pediatric hepatocellular tumors: A report from the Children's Hepatic tumors International Collaboration (CHIC)
Authors: Cho Soo‐Jin , Ranganathan Sarangarajan , Alaggio Rita , Maibach Rudolf , Tanaka Yukichi , Inoue Takeshi , Leuschner Ivo , de Krijger Ronald , Vokuhl Christian , Krailo Mark , Malogolowkin Marcio , Meyers Rebecka , Czauderna Piotr , Hiyama Eiso , Ansari Marc , Morland Bruce , Trobaugh‐Lotrario Angela , O'Neill Allison F. , Rangaswami Arun , Häberle Beate , López‐Terrada Dolores 
Published: June 2023

AbstractBackgroundLiver tumors are rare in children with histologic heterogeneity that makes diagnosis challenging. Systematic histopathological review, performed as part of collaborative therapeutic protocols, identified relevant histologic subtypes that are important to distinguish. The Children's Hepatic tumors International Collaboration (CHIC) was established to study pediatric liver tumors on a global scale and led to establishment of a provisional consensus classification for use in international clinical trials. The current study is the validation of this initial classification and first large‐scale application by international expert reviewers.ProcedureThe CHIC initiative includes data from 1605 children treated on eight multicenter hepatoblastoma (HB) trials. Review of 605 available tumors was performed by seven expert pathologists from three consortia (US, EU, Japan). Cases with discordant diagnoses were collectively reviewed to reach a final consensus diagnosis.ResultsOf 599 cases with sufficient material for review, 570 (95.2%) were classified as HB by all consortia, and 29 (4.8%) as non‐HB, which included “hepatocellular neoplasm, NOS” and malignant rhabdoid tumors.453 of 570 HBs were classified as epithelial by final consensus. Some patterns (i.e., small cell undifferentiated, macrotrabecular, cholangioblastic) were selectively identified by reviewers from different consortia. All consortia identified a similar number of mixed epithelial–mesenchymal HB.ConclusionsThis study represents the first large‐scale application and validation of the pediatric malignant hepatocellular tumors consensus classification. It is a valuable resource to train future generations of investigators on accurate diagnosis of these rare tumors and provides a framework for further international collaborative studies and refinement of the current classification of pediatric liver tumors.
Joint influence of architectural and spatiotemporal factors on the presence of Aedes aegypti in urban environments
Authors: Liao Jhih‐Rong , Tu Wu‐Chun , Chiu Ming‐Chih , Kuo Mei‐Hwa , Cheng Hui‐Ching , Chan Chia‐Chun , Dai Shu‐Mei 
Published: June 2023

AbstractBACKGROUNDUrbanization has led to the proliferation of high‐rise buildings, which have substantially influenced the distribution of dengue vectors, such as Aedes aegypti (L.). However, knowledge gaps exist regarding the individual and combined effects of architectural and spatiotemporal factors on dengue vector. This study investigated the interrelationship between Ae. aegypti presence, building architectural features, and spatiotemporal factors in urban environments.RESULTSThe mosquito Ae. aegypti presence varied by location and seasons, being higher in outdoor environments than in indoor environments. Lingya (Kaohsiung City, Taiwan) had the highest mosquito numbers, particularly in basement and first floor areas. Ae. aegypti was found on multiple floors within buildings, and their presence was greater in summer and autumn. The XGBoost model revealed that height within a building, temperature, humidity, resident density, and rainfall were key factors influencing mosquito presence, whereas openness had a relatively minor impact.CONCLUSIONTo effectively address the problems caused by urbanization, the three‐dimensional distribution of Ae. aegypti, including their spatial distribution across heights and areas within the urban environment, must be considered. By incorporating these multiple factors, this approach provides valuable insights for those responsible for urban planning and disease management strategies. Understanding the interplay between architectural features, environmental conditions, and the presence of Ae. aegypti is essential for developing targeted interventions and mitigating the adverse impacts of urbanization on public health. © 2023 Society of Chemical Industry.
Quantum Sensing via Magnetic‐Noise‐Protected States in an Electronic Spin Dyad
Authors: Meriles Carlos A. , Zangara Pablo R. , Pagliero Daniela 
Published: June 2023

AbstractExtending the coherence lifetime of a qubit is central to the implementation and deployment of quantum technologies, particularly in the solid state where various noise sources intrinsic to the material host play a limiting role. This study examines theoretically the coherent spin dynamics of a hetero‐spin system formed by a spin featuring a non‐zero crystal field and in proximity to a paramagnetic center . An analysis of the energy level structure of the dyad shows this system exhibits apair of levels separated by a magnetic‐field‐insensitive energy gap, which can be exploited to create long‐lived zero‐quantum coherences. It is found that these coherences are selectively sensitive to “local”—as opposed to “global”—magnetic field fluctuations, suggesting these spin dyads can serve as a nanoscale gradiometer for precision magnetometry. On the other hand, the distinct response of either spin species to electric or thermal stimuli allows one to implement alternative sensing protocols for magnetic‐noise‐free electrometry and thermometry.
Hormonal support in women with Asherman syndrome does not lead to better outcomes: A randomized trial
Authors: Hanstede Miriam M. F. , van Stralen Karlijn J. , Molkenboer Jan F. M. , Veersema Sebastiaan , Emanuel Mark Hans 
Published: June 2023

AbstractPurposeThe purpose of the study was to investigate if adjuvant hormones after successful adhesiolysis lead to a reduction in spontaneous recurrence of adhesions and influence reproductive outcomes.MethodsA single‐blind randomized controlled trial comparing administration of oral estrogen (the usual care group) with not giving estrogen (no estrogen) in women after successful adhesiolysis for Asherman syndrome. Women were included between September 2013 and February 2017, with a follow‐up of 3 years to monitor recurrences and reproductive outcomes. Analyses were based on an intention to treat analyses. This study was registered under NL9655.ResultsA total of 114 women were included. At 1 year, virtually all patients (except 3) were either having a recurrence or were pregnant. Women who did not receive estrogen did not have more recurrences of adhesions in the first year prior to pregnancy (66.1% in the usual care group, 52.7% in the no‐estrogen group, p = 0.15). Of the women in usual care, 89.8% got pregnant within 3 years, and 67.8% got a living child; this was 83.6% and 60.0%, respectively, in the no‐estrogen group (p = 0.33 and p = 0.39, respectively).ConclusionUsual care does not lead to better outcomes as compared with not giving exogenous estrogen but is associated with side effects.