bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Effects of Astrocyte Manipulations on Learned Motor Behavior and Neuronal Ensembles in the Motor Cortex
Authors: Delepine Chloe , Shih Jennifer , Li Keji , Gaudeaux Pierre , Sur Mriganka 
Published: March 2023

Although motor cortex is crucial for learning precise and reliable movements, whether and how astrocytes contribute to its plasticity and function during motor learning is unknown. Here, we report that astrocyte-specific manipulations in primary motor cortex (M1) during a lever push task alter motor learning and execution, as well as the underlying neuronal population coding. Mice that express decreased levels of the astrocyte glutamate transporter 1 (GLT1) show impaired and variable movement trajectories, whereas mice with increased astrocyte Gq signaling show decreased performance rates, delayed response times, and impaired trajectories. In both groups, which include male and female mice, M1 neurons have altered interneuronal correlations and impaired population representations of task parameters, including response time and movement trajectories. RNA sequencing further supports a role for M1 astrocytes in motor learning and shows changes in astrocytic expression of glutamate transporter genes, GABA transporter genes, and extracellular matrix protein genes in mice that have acquired this learned behavior. Thus, astrocytes coordinate M1 neuronal activity during motor learning, and our results suggest that this contributes to learned movement execution and dexterity through mechanisms that include regulation of neurotransmitter transport and calcium signaling.SIGNIFICANCE STATEMENTWe demonstrate for the first time that in the M1 of mice, astrocyte function is critical for coordinating neuronal population activity during motor learning. We demonstrate that knockdown of astrocyte glutamate transporter GLT1 affects specific components of learning, such as smooth trajectory formation. Altering astrocyte calcium signaling by activation of Gq-DREADD upregulates GLT1 and affects other components of learning, such as response rates and reaction times as well as trajectory smoothness. In both manipulations, neuronal activity in motor cortex is dysregulated, but in different ways. Thus, astrocytes have a crucial role in motor learning via their influence on motor cortex neurons, and they do so by mechanisms that include regulation of glutamate transport and calcium signals.
Biochemical identification of prepubertal boys with Klinefelter syndrome by combined reproductive hormone profiling using machine learning
Authors: Madsen Andre , Juul Anders , Aksglaede Lise 
Published: March 2023

Objective
Klinefelter syndrome (KS) is the most common sex chromosome disorder and genetic cause of infertility in males. A highly variable phenotype contributes to the fact that a large proportion of cases are never diagnosed. Typical hallmarks in adults include small testes and azoospermia which may prompt biochemical evaluation that typically shows extremely high follicle-stimulating hormone and low/undetectable inhibin B serum concentrations. However, in prepubertal KS individuals, biochemical parameters are largely overlapping those of prepubertal controls. We aimed to characterize clinical profiles of prepubertal boys with KS in relation to controls and to develop a novel biochemical classification model to identify KS before puberty.

Methods
Retrospective, longitudinal data from 15 prepubertal boys with KS and data from 1475 controls were used to calculate age- and sex-adjusted standard deviation scores (SDS) for height and serum concentrations of reproductive hormones and used to infer a decision tree classification model for KS.

Results
Individual reproductive hormones were low but within reference ranges and did not discriminate KS from controls. Clinical and biochemical profiles including age- and sex-adjusted SDS from multiple reference curves provided input data to train a ‘random forest’ machine learning (ML) model for the detection of KS. Applied to unseen data, the ML model achieved a classification accuracy of 78% (95% CI, 61–94%).

Conclusions
Supervised ML applied to clinically relevant variables enabled computational classification of control and KS profiles. The application of age- and sex-adjusted SDS provided robust predictions irrespective of age. Specialized ML models applied to combined reproductive hormone concentrations may be useful diagnostic tools to improve the identification of prepubertal boys with KS.
Rechtsfragen einer wettbewerblichen Generalklausel – Zur geplanten Einführung von § 32f GWB-E
Authors: Ackermann Thomas 
Published: March 2023

Zusammenfassung
Mit der geplanten Einführung einer wettbewerblichen Generalklausel soll ein Instrument Einzug in das deutsche Kartellrecht halten, das kartell- und regulierungsrechtliche Funktionen vereint. Der Beitrag zeigt unions- und verfassungsrechtliche Grenzen eines solchen Vorhabens auf, darüber hinaus auch Probleme seiner systemkonformen Einfügung in das einfache Recht. Sollte gleichwohl daran festgehalten werden, empfiehlt der Beitrag insbesondere eine deutlich engere, an den SIEC-Test anknüpfende Regelung, die Anordnung der Subsidiarität gegenüber vorrangigem Kartell- und Regulierungsrecht der EU, die Aufnahme einer Entschädigungspflicht sowie eine verfahrensrechtliche Aufwertung der Sektoruntersuchung.
Les romans paléologues et les contes arabes
Authors: Luzi Romina 
Published: March 2023

ABSTRACTThe Palaiologan romances, inspired by courtly romances, align their Western models with the Byzantine literary tradition and draw from more popular patterns, such as a narrative punctuated by meta-enunciative locutions, also employing magical items and ancestral fabulous motifs, such as the flying horse (derived from the tales of One Thousand and One Nights) or the jewel swallowed by a hawk and discovered in a fish's stomach, a motif employed in the Qamar az-Zaman tale of One Thousand and One Nights.
Determination of stearic acid and 12-hydroxyoctadecanoic acid in PEG-60 hydrogenated castor oil by HPLC-ELSD after alkaline hydrolysis
Authors: Duan Yu , Liu Xian-Zhao , Li En-Nian , Guo Zhong-Jing , Xu Xin-Jun 
Published: March 2023

AbstractA rapid and simple method for the determination of stearic acid and 12-hydroxystearic acid in PEG-60 hydrogenated castor oil by high performance liquid chromatography with evaporative light scattering detection was established. The oil sample was first pretreated by alkaline hydrolysis. The analysis was performed on a Zhongpu Develop XD-C18 column (250 mm × 4.6 mm, 5 µm) with gradient elution of methanol and 1% acetic acid aqueous solution at a flow rate of 1.2 mL·min−1 and a column temperature of 40 °C. The drift tube temperature of the evaporative light scattering detection system was set at 40 °C, and the pressure of carrier gas (N2) was 337 kPa. The regression equation revealed a good linear relation (r = 0.9993–0.9995) during the test ranges (119.1–1190.7 μg·mL−1 for 12-hydroxystearic acid, 10.7–107.4 μg·mL−1 for stearic acid). The detection limits of 12-hydroxystearic acid and stearic acid were 1.1 and 2.5 μg·mL−1, the limits of quantitation were 3.2 and 7.4 μg·mL−1, respectively. And the mean recoveries were 101.5 and 101.0%, the corresponding relative standard deviations (RSDs) were 2.1 and 2.8%, respectively. The RSDs corresponding to repeatability (n = 6) were both less than 1.7% in terms of precision. As to the stability, the test results remained stable after 8 h at room temperature (RSDs were both less than 2.6%). The developed method showed high sensitivity, recovery, repeatability and stability, which indicated that the method could be applied as a quality evaluation method for the determination of stearic acid and 12-hydroxyoctadecanoic acid in PEG-60 hydrogenated castor oil.
Flora vascular del municipio de Santos Reyes Tepejillo, Oaxaca, México
Authors: Hernández Cárdenas Rodrigo Alejandro , López-Ferrari Ana Rosa , Espejo-Serna Adolfo , Mendoza-Ruiz Aniceto 
Published: March 2023

Antecedentes: Santos Reyes Tepejillo, Oaxaca, carece de un inventario florístico integral. Elaborarlo permitirá contar con información para plantear estrategias de manejo y conservación de sus recursos vegetales.
Preguntas: ¿Cuántas y cuáles especies de plantas vasculares hay en el municipio de Santos Reyes Tepejillo y en qué tipo de vegetación se encuentran? ¿Cuál es el porcentaje de especies nativas, endémicas y catalogadas en alguna categoría de riesgo?
Descripción de datos: Flora vascular.
Sitios y años de estudio: Santos Reyes Tepejillo, Oaxaca, México; 2019 a 2021.
Métodos: Se realizaron viajes periódicos de recolección botánica; el material recolectado se herborizó y determinó con el uso de claves, la información recabada del trabajo de campo se complementó con la consulta de bases de datos y la revisión de especímenes en herbarios institucionales.
Resultados: Se registraron 536 especies, 336 géneros y 103 familias. Las familias Asteraceae (58 géneros/88 especies), Fabaceae (21/37) y Apocynaceae (13/23) sobresalen por su riqueza genérica y específica, mientras que a nivel de género los más diversos fueron Tillandsia, Salvia y Euphorbia. Doscientas trece especies son endémicas de México, 13 son exclusivas de Oaxaca y dos restringen su distribución a la zona de estudio; 111 especies se encuentran enlistadas en alguna categoría de riesgo.
Conclusiones: Santos Reyes Tepejillo concentra una notable riqueza específica y presenta un importante nivel de endemismo. El estudio documenta tres nuevos registros a nivel estatal y el hallazgo de tres nuevas especies. Es indispensable continuar con el trabajo de exploración en la zona de estudio y regiones adyacentes.
Ganarse la vida. La reproducción social en el mundo contemporáneo
Authors: Pérez Hernández Francisco 
Published: March 2023

Reseña del libro:
Pérez Castro, Ana Bella; Contreras Román, Raúl y Contreras Vargas, Jessica Itzel (eds.) (2021). Ganarse la vida. La reproducción social en el mundo contemporáneo. Universidad Nacional Autónoma de México.
Profamilia: estudio de caso sobre cambios institucionales graduales en la prestación de servicios de aborto en Colombia
Authors: Bohorquez Monsalve Viviana 
Published: March 2023

Este artículo trata sobre las transformaciones institucionales de los servicios de salud de Bogotá en aborto a través de un estudio de caso sobe Profamilia. Dicha entidad sin ánimo de lucro fue fundada en 1965, comprometida desde sus inicios con la lucha por los derechos y la salud reproductiva. Como prestador de servicios, Profamilia vivió profundas transformaciones graduales desde el año 2006, con la despenalización parcial del aborto en tres causales ordenada por la Corte Constitucional de Colombia. Después de la decisión constitucional, Profamilia pasó de no realizar ningún procedimiento de aborto, a convertirse progresivamente en el mayor proveedor de servicios. Por consiguiente, este artículo estudia la transformación de los servicios en el tiempo, empleando el método de análisis de cambios institucionales graduales propuesto por Mahoney y Thelen, para lograr realizar un estudio a profundidad sobre los cambios internos que se llevaron a cabo para lograr el aumento en los servicios y su relación con el marco legal vigente.
Long-term thromboprophylaxis in metallic aortic valve prosthesis using oral nattokinase-A case report
Authors: Dalal Dhaval , Gawali Vijaykumar 
Published: March 2023

Oral anticoagulation with a vitamin K antagonist like warfarin is the standard of care for thromboprophylaxis after cardiac valve replacement. However warfarin requires strict monitoring of INR to avoid bleeding.Bleeding is a major concern with warfarin, particularly in those at high risk. Nattokinase is an enzyme obtained from natto, a cheese-like food made of soybeans fermented with Bacillus subtilis, which has been consumed as a traditional food in certain Asian countries for more than 2000 years.Recent research has demonstrated that nattokinase has potent fibrinolytic activity and antithrombotic action. We present a case of a 37-year-old male who had undergone aortic valve replacement using a metallic prosthetic valve for rheumatic heart disease associated severe aortic regurgitation and has been maintained on oral nattokinase therapy for prophylaxis against thromboembolic complications post cardiac wall replacement since the last 12 years.This case highlights the role of oral nattokinase for thromboprophylaxis in valve prosthesis and other prothrombotic states. This case report presents the first documented case where oral nattokinase has been successfully used for long-term thromboprophylaxis in metallic aortic valve prosthesis.: We present a case of a 37-year-old male who had undergone aortic valve replacement using a metallic prosthetic valve for rheumatic heart disease associated severe aortic regurgitation and has been maintained on oral nattokinase therapy for prophylaxis against thromboembolic complications post cardiac wall replacement since the last 12 years.This case highlights the role of oral nattokinase for thromboprophylaxis in valve prosthesis and other prothrombotic states. This case report presents the first documented case where oral nattokinase has been successfully used for long-term thromboprophylaxis in metallic aortic valve prosthesis.
Employer Practices for Integrating People With Disabilities Into the Workplace: A Scoping Review
Authors: Wu Jia Rung , Iwanaga Kanako , Grenawalt Teresa , Mpofu Ngonidzashe , Chan Fong , Lee Beatrice , Tansey Timothy 
Published: March 2023

Background:Workplace inclusion contributes to job satisfaction and innovation. Integrating people with disabilities (PWDs) improves productivity, morale, creativity, problem-solving, and commitment. Previous evidence revealed that employers are ambivalent about integrating PWDs. There remains a paucity of literature that examines demand-side employment practices of integrating PWDs in the workplace.Objective:The present study comprehensively reviewed the demand-side employment literature to identify existing practices used to improve the integrating PWDs in the workplace.Methods:A scoping review was employed. Articles were retrieved from PsycInfo, Academic Search, Web-science, American Business Index, and ProQuest Dissertations & Theses Global and published in English from January 1985 to August 2017.Findings:The scoping review yielded 19 articles. Three themes were identified as common and effective employer practices, including (a) policy and allegation, (b) internal and external partnerships, and (c) organizational top-down management diversity support.Conclusion:The findings of this scoping review provide collective information for integrating PWDs in the workplace. Findings shed some light on employer and rehabilitation counselors to engage and assist employers in promoting an inclusive workplace climate.
Employer Practices for Customized Training for Onboarding of People With Disabilities
Authors: Chen Xiangli , Wu Jia-Rung , Grenawalt Teresa Ann , Mpofu Ngonidzashe , Chan Fong , Tansey Timothy N. 
Published: March 2023

Background:To improve employment outcome, systematic research that is based on demand-side needs is needed to clarify how employer practice factors can affect customized training efforts.Objective:The purpose of this study is to report the results of a scoping review to identify the best employer practices that are used to improve customized training efforts and results for people with disabilities in the workplace.Method:A scoping review of demand-side employment literature was conducted. Five databases were searched for articles published between 1985 and 2017. After filtering articles based on the search criteria, the final number of articles included in the analysis was 27.Findings:We identified three key themes related to customized training efforts. These include: (a) employment support, (b) work values, and (c) employment temperature.Conclusion:The findings of this scoping review provide valuable information for disability employment professionals and rehabilitation counselors to engage and assist employers in relation to customized training efforts.
PERLINDUNGAN DATA PRIBADI KONSUMEN PENGGUNA JASA CETAK KARTU VAKSIN COVID-19 DI INDONESIA
Authors: Ningsih Dwi Rahayu , Sarip Muhammad , Pertiwi Hana 
Published: March 2023

ABSTRAK

Metode penelitian ini menggunakan jenis penelitian Library Research yaitu penelitian yang mengambil dan menganalisis data dari sumber kepustakaan seperti peraturan perundang-undangan, buku teks, atau kitab yang mempunyai relevansi dan hubungan dengan fokus penelitian.Dari hasil penelitian dapat disimpulkan bahwa bentuk perlindungan hukum data pribadi konsumen berupa sanksi administratif bagi penyedia jasa yang melanggar ketentuan berdasarkan Pasal 36 Ayat (1) Permenkominfo No.20 Tahun 2016 Tentang Perlindungan Data Pribadi Dalam Sistem Elektronik dan sanksi pidana sesuai ketentuan Pasal 95A UU No.24 Tahun 2013 Tentang Administrasi Kependudukan. Sedangkan dalam Islam, prinsip privasi dilindungi dalam QS. An-Nur (27) yang melarang untuk melakukan perbuatan yang menimbulkan kerugian bagi orang lain khususnya dalam hal data pribadi.

Kata Kunci: Perlindungan Hukum, Data Pribadi, Konsumen, Kartu Vaksin Covid-19
PERAN KUA DALAM PENCEGAHAN PERNIKAHAN DI BAWAH UMUR PASCA BERLAKUNYA UU NOMOR 16 TAHUN 2019
Authors: Sanjaya Jaka , HAK Nurmala , Ifrohati Ifrohati 
Published: March 2023

Penelitian ini dilator belakangi oleh adanya peran KUA terhadap kebijakan pemerintah dalam pencegahan pernikahan anak dibawah umur pasca berlakunya Undang-Undang Nomor 16 Tahun 2019. Tujuan penelitian ini adalah untuk mengetahui peran KUA dalam pencegahan pernikahan anak dibawah umur di KUA Kecamatan Lubuk Batang Kabupaten OKU dan untuk mengetahui Efektivitas peran KUA terhadap kebijakan dalam pencegahan pernikahan anak dibawah umur di KUA Kecamatan Lubuk Batang Kabupaten OKU.
Jenis penelitian dalam penelitian ini adalah jenis penelitian Lapangan (field research). Jenis Data adalah Data Kualitatif, dengan sumber data Primer, sekunder dan tersier. Sedangkan tehnik pengumpulan data dalam penelitian ini menggunakan wawancara dan dokumentasi. Tehnik analisa data yang digunakan yaitu deskriptif kualitatif. Kemudian pembahasan ini disimpulkan secara deduktif yaitu dari umum ke khusus.
Dalam penelitian ini penulis ada beberapa hal yaitu pertama peran KUA Kecamatan Lubuk Batang Kabupaten OKU terhadap kebijakan dalam pencegahan pernikahan anak dibawah umur pasca berlakunya Undang-Undang Nomor 16 Tahun 2019. Keterangan tersebut menjelaskan bahwakepala KUA Lubuk Batang Kabupaten OKU berperan sebagai BP4 Kecamatan memiliki program yang dinamakan dengan Suscatin atau Kursus Calon Pengantin sebagai wadah yang ditujukan bagi para pengantin untuk dibimbing, diarahkan dan dinasehati termasuk pernikahan dini yang akan dilakukan, dalam program suscatin ini para remaja yang akan menikah dijelaskan mengenai dampak pernikahan, permasalahan dalam pernikahan khususnya mengenai aturan batasan umur yang ditetapkan oleh Pemerintah bagi masyarakat yaitu berumur 19 tahun. Jika umur calon pengantin belum berumur 19 tahun maka tetap di berikan program suscatin namun mereka belum bisa untuk menikah dikarenakan belum cukup umur berdasarkan Undang-Undang Nomor 16 Tahun 2019. Kedua, efektivitas peran KUA terhadap kebijakan dalam pencegahan pernikahan anak dibawah umur di KUA Kecamatan Lubuk Batang Kabupaten OKU. Berdasarkan data yang saya dapatkan dari kepala KUA Kecamatan Lubuk Batang Kabupaten OKU bahwa peran kepala KUA dalam keefektipan mengenai kebijakan dalam pencegahan pernikahan anak dibawah umur di KUA Kecamatan Lubuk Batang Kabupaten OKU belum dapat dilaksanakan sepenuhnya.di sisi lain jika masih ada remaja yang masih ingin melakukan pernikahan maka akan diberikan dispensasi nikah. Sebagaimana dijelaskan dalam Pasal 7 ayat (2) Undang-UndangNomor 16 Tahun 2019 tentang Perkawinan.

Kata kunci : Peran KUA, Pernikahan dibawah umur, Undang-undang Nomor 16 Tahun 2019
MANAJEMEN KELUARGA SEBAGAI PERSIAPAN MENUJU KELUARGA SAKINAH
Authors: Azhari Ari , Bahauddin Ahmad , Fasya Rafly 
Published: March 2023

Pasangan suami istri ini layak menyandang predikat keluarga sakinah teladan diantaranya dikarenakan situasi keluarga yang taat dalam beribadah serta selalu musyawarah dalam pengambilan kebijakan, serta memahami ajaran agama, Pancasila, dan UUD 1945. Tujuan penelitian ini ialah untuk mengetahui manajemen yang benar pada suatu kelurga, sehingga dengan manajemen yang tepat maka akan tercipta keluarga sakinah. Metode penelitian ini menggunakan metode studi kepustakaan dengan melihat berbagai literatur untuk mendapatkan jawaban. Hasil Penelitian ialah terdapat beberapa faktor pembentukan manajemen keluarga sakinah yaitu : 1). Landasan Keagaman, 2). Keseimbangan, 3). Cinta Kasih, 4). Komitmen Perkawinan. Kesimpulan yang didapat untuk membentuk keluarga sakinah ialah dengan menjalin komunikasi yang baik, saling mencintai, dan tanggung jawab. Semua ini berdasarkan pada al-Quran dan as-Sunnah.
Kata Kunci : Manajemen; Keluarga; Sakinah
The subtleties of insulin treatment in patients with lipodystrophy
Authors: YİLDİRİM SİMSİR Ilgin , SOYALTİN Utku Erdem , CETİNKALP Sevki , AKİNCİ Baris 
Published: March 2023

In the treatment of Diabetes Mellitus (DM), which develops on the basis of insulin resistance in
patients with lipodystrophy (LD) often require high doses of insulin. Traditionally in practice is to
gradually increase the insulin doses to achieve blood glucose normalization.
The fact that high insulin doses require a larger injection volume, which causes impairment in the
absorption of insulin from the subcutaneous tissue to the circulation.
In this article, we discussed the clinical approach to insulin practice in the treatment of DM in patients
with LD and reviewed systematically the literature.
Is a forged signature an “apple” or a “fruit salad”?
Authors: Elmaleh Terry 
Published: March 2023

This article is penned as a result of the continuous significant findings in my daily forensic handwriting examination practice and experience.
The methodology and process followed in any forensic handwriting examination are central to its interpretation and reliability – the repeatability and reproducibility of the same tests giving the same results; its validity concerning the appropriateness of the chosen methodology and process; and the resulting accuracy or discriminative reliability of the expert opinion in reflecting the true state of the evidence.
In this regard, the present article poses the question firstly as to whether a forged signature is fundamentally a signature or handwriting? Once the implication of that question is understood and answered, the ensuing one is: in the interests of reliability, validity, accuracy, and best practice, what categories of comparison samples of the forger’s writing should be used as evidence to analyse, compare, and evaluate a questioned signature, the forger’s signatures, initials, or handwriting?
In short: in the pursuit of identifying authorship of any forged writing, and specifically a forged signature, whether disguised, free-hand simulated, traced, or even spuriously created, should the so-called apple be compared to apples (which would imply comparison to the signatures of the forger in the case of a forged signature), or is the forged signature a fruit salad that should be compared to the full potentiality and reper-toire of the entire writing skill range and master pattern of the suspected forger?