bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement of Few-Group Homogenized Cross-Sections for RSG-GAS In-Core Fuel Management Code Batan-FUEL
Authors: Pinem Surian , Hartanto Donny , Liem Peng Hong , Luthfi Wahid 
Published: January 2023

Abstract
This paper presents the generation and the verification of the few-group homogenized cross section for Batan-FUEL code. This code is routinely used for fuel management in the G. A. Siwabessy Multipurpose Reactor (RSG-GAS). The Monte Carlo code Serpent 2 code, in conjunction with the latest nuclear data library ENDF/B-VIII.0, was used. Calculations using the existing newly generated few-group cross section data were carried out for the 88th core. The calculated core parameters such as excess reactivity and control rod worth are compared to the available experimental data. On the other hand, the fuel burnup fraction and radial power peaking factor (PPF) are compared to the results of Serpent 2. It was shown that the new cross section data have more consistency and a better agreement excess reactivity and control rod worth compared to the experimental data. Similarly, the U-235 burnup fraction and radial power peaking factor by the new cross section data are also shown to concur well with Serpent 2. The newly generated few-group cross section is recommended to replace the existing ones for the fuel management of RSG-GAS.
Fluid End Blocks: Numerical Analysis of Autofrettage and Reautofrettage Based Upon a True Material Model
Authors: Hu Zhong , Parker Anthony P. 
Published: January 2023

AbstractFluid end blocks (FEBs) are the most important components of hydraulic fracturing pumps. A potential important application of the hydraulic autofrettage process (HAP) is to strengthen the fatigue-prone FEBs. This creates a favorable compressive residual stress field near to the critical surface locations within the component and serves to increase its pressure-bearing capacity and/or improve lifetime. This requires a fundamental understanding and modeling of the complex mechanics of the HAP in order to accurately predict such residual stresses. The key outstanding modeling issue is the complex material behavior, dominated by the Bauschinger effect and associated with reversed yielding. This effect differs throughout the FEB. It has been modeled for plane axisymmetric cylinders but has not previously been incorporated into FEB analyses. In this paper, a newly developed finite element analysis (FEA)-based user programable function (UPF), featuring true material constitutive behavior, i.e., replicating an existing Bauschinger-effect characterization (BEC), is adopted to accurately simulate the HAP and quantitatively investigate the stress–strain evolution and residual stress fields throughout the FEB. This simulation is then compared with FEA modeling by a traditional bilinear kinematic hardening material model to indicate the importance of the accuracy of the material constitutive model in determining appropriate residual stresses and strains. An autofrettage pressure of 500 MPa generally achieves net compressive hoop stresses at each of four critical crossbore location. Finally, a prospective re-autofrettage sequence is described; approximate modeling suggests an improvement that might permit operation at higher working pressure.
Prediction of the Time to Failure of Boiler Tubes Flawed With Localized Erosion
Authors: Kalu Ifeanyi Emmanuel , Inglis Helen Mary , Kok Schalk 
Published: January 2023

AbstractA failure mechanism prevalent with boiler tubes operating in harsh environmental conditions is localized erosion. The consequence of the erosion mechanism is a substantial reduction of the tube thickness, ultimately leading to plastic collapse and consequently rupturing of the tubes. Locating and repairing all the affected tubes within the boiler are time consuming and expensive. It will be worthwhile to rank all the identified flaws so that critical flaws that cannot survive till the next scheduled shutdown are prioritized for repair. Consequently, nonlinear structural analysis was conducted on various boiler tubes that failed by localized erosion. The tubes had a wide range of localized erosion flaws that required a detailed assessment technique. The failure was evaluated numerically using various stress and strain-based failure criteria as well as performing the American Petroleum Institute and the American Society of Mechanical Engineers (API-ASME) fitness-for-service (FFS) assessment on the tubes. A projected time to failure (Pt) for each tube based on the various criteria used in this study was determined. This enabled the ranking of the flawed tubes based on the priority of their repair. The outcome of this study demonstrates the potential for a tool which will enable industry users to prioritize the replacement or repair of critically flawed tubes and avert replacing tubes that are still safe for future operation.
Acoustic Radiation From Stiffened Double Concentric Large Cylindrical Shells: Part I Circumferential Harmonic Waves
Authors: Cao Xiongtao 
Published: January 2023

Abstract
Acoustic radiation from stiffened double concentric large cylindrical shells with periodic cavities is analytically investigated via circumferential harmonic waves driven by a point force. The vibration of double isotropic circular cylindrical shells is described by the first-order shear deformation shell theory. One set of uniformly spaced annular bulkheads connects the inner and outer cylindrical shells. In-plane motion equations of the annular bulkheads are expressed by two displacement potential functions. Sound pressure loadings of periodic cavities exerting on the inner and outer cylindrical shells are derived according to the Fourier transform and Poisson summation formula. Far-field sound pressure of the stiffened double cylindrical shells is obtained using the stationary phase method and acoustic radiation features of stiffened double concentric large cylindrical shells with periodic cavities are analyzed in terms of sound pressure power spectra and sound pressure level. Acoustic propagation features of stiffened double cylindrical shells with or without acoustic cavities are shown.
Acoustic Radiation From Stiffened Double Concentric Large Cylindrical Shells: Part II Creeping Waves
Authors: Cao Xiongtao 
Published: January 2023

Abstract
Acoustic radiation from stiffened double concentric large cylindrical shells with periodic cavities is analytically examined in the medium and high frequency range using the Sommerfeld–Watson transform. Creeping wave acoustic model of the stiffened double cylindrical shells in the shadow, penumbra, and illuminated regions is established by the residue theorem. An asymptotic expression of far-field acoustic pressure is derived in the geometrical acoustic zone according to the stationary phase method. Sound field of the bare or stiffened double cylindrical shells with annular fluid is determined by the creeping wave poles in the broad circumferential region. Mechanisms of creeping wave propagation through the stiffened double cylindrical shells are shown. There are a great many elastic and acoustic waves that cannot transmit through the annular fluid, annular bulkheads, and periodic cavities with a moderate gap between the double circular cylindrical shells. Acoustic boundary layer theories are proposed to describe sound propagation through the annular fluid and bulkheads for the creeping waves.
Supplemental Material: Quantitative record of the Neoarchean water cycle from a 2.67 Ga magmatic-hydrothermal system, Fennoscandian Shield
Authors: Zakharov David , al. et 
Published: January 2023

<p>Sample description, methods, oxygen-isotope notations and triple oxygen-isotope fractionation, Figures S1–S5, and Tables S1–S3. </p>
Validation of a paediatric sepsis screening tool to identify children with sepsis in the emergency department: a statewide prospective cohort study in Queensland, Australia
Authors: Gilholm Patricia , Gibbons Kristen , Lister Paula , Harley Amanda , Irwin Adam , Raman Sainath , Rice Michael , Schlapbach Luregn J 
Published: January 2023

ObjectiveThe Surviving Sepsis Campaign guidelines recommend the implementation of systematic screening for sepsis. We aimed to validate a paediatric sepsis screening tool and derive a simplified screening tool.DesignProspective multicentre study conducted between August 2018 and December 2019. We assessed the performance of the paediatric sepsis screening tool using stepwise multiple logistic regression analyses with 10-fold cross-validation and evaluated the final model at defined risk thresholds.SettingTwelve emergency departments (EDs) in Queensland, Australia.Participants3473 children screened for sepsis, of which 523 (15.1%) were diagnosed with sepsis.InterventionsA 32-item paediatric sepsis screening tool including rapidly available information from triage, risk factors and targeted physical examination.Primary outcome measureSenior medical officer-diagnosed sepsis combined with the administration of intravenous antibiotics in the ED.ResultsThe 32-item paediatric sepsis screening tool had good predictive performance (area under the receiver operating characteristic curve (AUC) 0.80, 95% CI 0.78 to 0.82). A simplified tool containing 16 of 32 criteria had comparable performance and retained an AUC of 0.80 (95% CI 0.78 to 0.82). To reach a sensitivity of 90% (95% CI 87% to 92%), the final model achieved a specificity of 51% (95% CI 49% to 53%). Sensitivity analyses using the outcomes of sepsis-associated organ dysfunction (AUC 0.84, 95% CI 0.81 to 0.87) and septic shock (AUC 0.84, 95% CI 0.81 to 0.88) confirmed the main results.ConclusionsA simplified paediatric sepsis screening tool performed well to identify children with sepsis in the ED. Implementation of sepsis screening tools may improve the timely recognition and treatment of sepsis.
Telehealth use in Australian primary healthcare during COVID-19: a cross-sectional descriptive survey
Authors: Halcomb Elizabeth J , Ashley Christine , Dennis Sarah , McInnes Susan , Morgan Mark , Zwar Nicholas , Williams Anna 
Published: January 2023

ObjectiveThis study aimed to investigate Australian primary healthcare professionals’ experiences of the rapid upscaling of telehealth during COVID-19.DesignA cross-sectional survey.Participants and settingTwo hundred and seventeen general practitioners, nurses and allied health professionals employed in primary healthcare settings across Australia were recruited via social media and professional organisations.MethodsAn online survey was disseminated between December 2020 and March 2021. The survey comprised items about individual demographics, experiences of delivering telehealth consultations, perceived quality of telehealth consultations and future perceptions of telehealth.ResultsTelephone was the most widely used method of providing telehealth, with less than 50% of participants using a combination of telephone and video. Key barriers to telehealth use related to the inability to undertake physical examination or physical intervention. Telehealth was perceived to improve access to healthcare for some vulnerable groups and those living in rural settings, but reduced access for people from non-English-speaking backgrounds. Quality of telehealth care was considered mostly or somewhat the same as care provided face-to-face, with actual or perceived negative outcomes related to missed or delayed diagnosis. Overwhelmingly, participants wanted telehealth to continue with guaranteed ongoing funding. Some 43.7% of participants identified the need to further improve telehealth models of care.ConclusionThe rapid shift to telehealth has facilitated ongoing care during the COVID-19 pandemic. However, further work is required to better understand how telehealth can be best harnessed to add value to service delivery in usual care.
Short-term and long-term effects of Sanming healthcare system reform on drug-related expenditures for rural patients with cancer in public hospitals: an interrupted time series analysis using segmented regression model in China
Authors: Fu Rong , Chen Qidong , Lin Yulan , Lin Zheng , Zheng Zhenquan , Hu Zhijian 
Published: January 2023

ObjectivesTo assess the effects of ‘Sanming model’ on drug-related expenditures.DesignInterrupted time series analysis with two time points was conducted to analyse the effects of ‘Sanming model’ using segmented regression model.SettingTwo hundred and eighty public hospitals in Fujian province in China.ParticipantsA total of 777 171 inpatients and 792 743 outpatients with cancer who participated in New Rural Cooperative Medical Scheme (NRCMS) were included.Interventions‘Sanming model’ was issued by Sanming government in February 2013 and spread to other cities in Fujian province in January 2015.Primary outcome measuresFour drug-related expenditure variables.ResultsAmong inpatients, total drug expenditures and drug expenditures covered by NRCMS dropped instantly after the reform in all hospitals. Although there was insignificant change during the short-term reform period, the total drug expenditures and drug expenditures covered by NRCMS decreased at the rate of ¥20.3 (p=0.0099) and ¥18.8 (p=0.0341) per capita month-to-month during the long-term reform period in Sanming hospitals, respectively. Among outpatients, total drug expenditures and drug expenditures covered by NRCMS decreased at the rate of ¥20.8 (p=0.0335) and ¥18.4 (p=0.0242) per capita month-to-month during the short-term reform period in Sanming hospitals, respectively. However, the downward trend did not continue into the long term. The significant decreases in trend of drug expenditures uncovered by NRCMS were only observed after the reform in provincial hospitals. The ratio of drug expenditures to inpatient (outpatient) expenditures decreased after the reform in all hospitals.Conclusions‘Sanming model’ had long-term effect in reducing total drug expenditures, drug ratio and drug expenditures covered by NRCMS for rural inpatients with cancer and only short-term positive effect for outpatients. However, there was limited effect of ‘Sanming model’ on drug expenditures uncovered by NRCMS. ‘Sanming model’ still needs to accumulate experiences and improves the reform measures dynamically.
Emergency admission plasma D-dimer: a novel predictor for symptomatic intracranial hemorrhage after thrombectomy in acute ischemic stroke
Authors: Qiu Kai , Jia Zhen Yu , Cao Yuezhou , Zhao Lin-Bo , Zu Qingquan , Shi Hai-Bin , Liu Sheng 
Published: January 2023

BackgroundSymptomatic intracranial hemorrhage (sICH) is a common and severe complication in patients with acute ischemic stroke (AIS) after treatment with thrombectomy.ObjectiveTo explore the ability of admission plasma D-dimer levels to predict sICH after thrombectomy.MethodsBetween February 2018 and August 2021, consecutive patients with AIS who underwent thrombectomy at our single comprehensive stroke center were retrospectively enrolled. sICH was defined according to the criterion of the Heidelberg Bleeding Classification. Logistic regression analysis was performed to determine the risk factors of sICH. The overall discriminative ability of D-dimer levels in predicting sICH was evaluated by adopting a receiver operating characteristic (ROC) curve.ResultsOf the 395 enrolled patients, 48 (12.2%) had sICH. Patients with sICH were older (72.9 vs 69.3 years, P=0.037), more often female (62.5% vs 45.5%, P=0.027), had higher D-dimer levels (2.70 vs 0.74 mg/L, P<0.001), higher National Institutes of Health Stroke Scale score (20 vs 15, P<0.001), lower Alberta Stroke Program Early CT Score (8 vs 9, P<0.001), a higher proportion of internal carotid artery occlusions (56.2% vs 30.3%, P<0.001), and less commonly had large-artery atherosclerosis stroke etiology (12.5% vs 32.3%, P=0.010) than patients without sICH. After adjustment for potential confounders, D-dimer levels (adjusted OR=2.45, 95% CI 1.75 to 3.43, P<0.001) remained significantly associated with sICH. Based on the ROC, the D-dimer as a predictor for predicting sICH, presented with a specificity of 86.2%, a negative predictive value of 94.6%, and an area under the curve of 0.774.ConclusionElevated admission D-dimer levels are an independent predictor of sICH in patients with AIS after thrombectomy.
Efficacy of yeast and garlic extract mixture on growth performance, tract digestibility, excreta microbiota, gas emission, blood profile, and meat quality in broiler
Authors: Biswas Sarbani , Kim In Ho 
Published: January 2023

This experiment was accompanied to determine the use of yeast and garlic extract mixture in broiler diets on growth performance, nutrient absorption, excreta microbiota, blood profiles, and meat quality. A total of 792 male Ross 308 broilers (1-day-old, body weight 41 ± 0.5 g, and 5 weeks trial) were randomly allocated. Birds were arbitrarily assigned to one of four nutritive treatments (11 replicates; 18 birds/replicate). A basal diet (CON) was supplemented with 0.1%, 0.2%, and 0.3% yeast–garlic mixture (YGM). Body weight gain linearly increased during the overall period and tended to increase from day 21 to day 35, while feed intake showed a tendency to increase during the overall period by YGM inclusion. However, Salmonella counts linearly decreased, but Lactobacillus and Escherichia coli counts remained unaffected. Excreta CO2 emissions were linearly reduced; nevertheless, other noxious gas emissions were not affected. Furthermore, YGM supplementation elicited a tendency for improved lymphocytes and linearly increased IgG. However, feed conversion ratio, mortality, nutrient utilization, and meat quality were not influenced. YGM addition (0.1%, 0.2%, and 0.3%) linearly improved broiler growth performance by decreasing microbiota and gas emission and increasing blood parameters. So, the proper dose of YGM was 0.3%.
Effect of lupin (Lupinus angustifolius) as a soybean meal replacement on the performance, meat quality, and blood parameters of broilers
Authors: Lim Chun Ik , Choi Nag Jin 
Published: January 2023

This study investigated the effects of dietary lupin (LP) as a replacement for soybean meal (SBM) on the performance, meat quality, and blood parameters of broilers. A total of 960 1-day-old Ross 708 broilers were divided into four dietary groups. The four diets were formulated with different levels of dehulled LP content in place of SBM; LP0: 0, LP50: 50, LP100: 100, and LP200: 200 g/kg. There was a trend ( P < 0.10) for reduced weight gain in the LP200 group compared with other groups. The feed conversion ratio was higher ( P < 0.05) in the LP200 group than in the LP0 and LP50 groups. Concerning breast meat characteristics, the lightness color (L*) was lower ( P < 0.05) in the LP200-fed group compared with the LP0 group. Polyunsaturated fatty acids were higher ( P < 0.05) in LP100- and LP200-fed chickens than in LP0-fed chickens. Serum HDL cholesterol was significantly ( P < 0.05) higher in the group fed LP200 compared with the groups fed LP0 and LP50. A higher serum concentration of interleukin (IL)-2 was found in groups fed LP100 and LP200 than in groups fed LP0 and LP50. Our results suggest that LP could be a dose-dependent SBM substitute, and that the optimal level of LP inclusion is approximately 100 g/kg.
CD8+ T cell–Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance
Authors: Lao Liyan , Zeng Wenfeng , Huang Penghan , Chen Huiping , Jia Zishuo , Wang Pei , Huang Di , Chen Jianing , Nie Yan , Yang Linbin , Wu Wei , Liu Jiang 
Published: January 2023

AbstractThe therapeutic efficacy of chemotherapy is in part a result of its ability to enhance adaptive antitumor immune responses. However, tumor cells exploit various evasion mechanisms to escape the immune attack and blunt chemosensitivity. Herein, we report that through single-cell profiling of the tumor immune microenvironment, we identified a subset of CD161-overexpressing CD8+ T cells enriched in chemoresistant tumors. CD161 engagement repressed the calcium influx and cytolytic capacity of CD8+ T cells through acid sphingomyelinase activation and ceramide generation. Targeting CD161 in adoptively transferred cytotoxic T lymphocytes enhanced antitumor immunity and reversed chemoresistance in patient-derived xenografts in vivo. Clinically, CD161 expression on CD8+ T cells was associated with chemoresistance and shortened patient survival. Our findings provide insights into novel immunosuppressive mechanisms in chemoresistance and highlight targeting CD161 as a potential therapeutic strategy.
ULKUS KORNEA PERFORASI SEBAGAI DAMPAK PENGGUNAAN STEROID TANPA INDIKASI: SEBUAH LAPORAN KASUS
Authors: Vilado Irene , Herwindo Dicky , David Nathanael , Chandra Beryl , Sagita Zendy 
Published: January 2023

Ulkus kornea merupakan suatu kondisi infeksi kornea yang melibatkan lapisan epitel hingga stroma. Penggunaan steroid tanpa indikasi masih menjadi hal yang masif di fasilitas kesehatan tingkat pertama (FKTP) serta berpotensi mengakibatkan berbagai komplikasi. Steroid dapat menunda penyembuhan epitel dan dapat menginduksi terjadinya perforasi, serta inhibisi neutrofil sehingga dapat mengeksaserbasi infeksi. Pemahaman secara holistik mengenai ulkus kornea terutama pendekatan diagnosis baik secara klinis maupun penunjang hingga manajemen efektif bagi pasien sangat penting untuk dipahami oleh setiap dokter terutama pada pelayanan FKTP. Tujuan dari laporan kasus ini adalah untuk memberikan pengetahuan terkait penegakan diagnosis, tatalaksana steroid dan penggunaan periosteal graft pada ulkus kornea yang sudah mengalami perforasi.
Seorang pria berusia 39 tahun datang ke RSUD Dr. Saiful Anwar Malang (RSSA) dengan keluhan mata kiri kemerahan, nyeri, dan muncul lesi berwarna putih yang meluas. Keluhan tersebut muncul pada mata kiri setelah terkena pelepah pisang satu bulan yang lalu. Awalnya hanya muncul bintik putih dan kemudian meluas. Pasien telah mendapat pengobatan dari FKTP dan Fasilitas Kesehatan Tingkat Lanjutan (FKTL) namun dirujuk ke RSSA karena terdapat potensi komplikasi.
Pendekatan diagnosis secara holistik dan penatalaksanaan yang tepat indikasi penting untuk mencegah komplikasi ulkus kornea khususnya dalam penggunaan steroid.
Aspergilosis Kutis Primer dengan Gambaran Klinis Menyerupai Tuberkulosis Verukosa Kutis
Authors: Dani Adinda Amalia , Widasmara Dhelya 
Published: January 2023

Pendahuluan: Aspergilosis kutis primer (AKP) adalah infeksi jamur invasif pada kulit yang jarang terjadi namun dapat mengancam jiwa. Penyakit ini disebabkan oleh Aspergillus spp dan termasuk ke dalam mikosis profunda (subkutan).
Laporan kasus: Seorang laki-laki berusia 63 tahun datang dengan keluhan luka pada kulit di kaki kanan sejak 5 tahun yang gatal, nyeri dan bernanah. Pemeriksaan dermatologis menunjukkan papul dan plak eritematosa multipel, permukaan verukosa sebagian tertutup krusta kuning kecoklatan, xerosis dan beberapa ulkus dengan pus. Diagnosis banding yang diajukan adalah Tuberkulosis verukosa kutis, Kromoblastomikosis dan Misetoma. Hasil kultur jaringan menunjukkan Aspergillus niger. Hasil biopsi menunjang diagnosis mikosis profunda. Pasien kemudian didiagnosis sebagai Aspergilosis kutis primer, diberikan terapi dosis denyut Itrakonazol dan mengalami perbaikan klinis dalam 2 minggu.
Kesimpulan: Gambaran klinis atipikal pada pasien ini memberikan tantangan diagnostik bagi dermatologis. Pentingnya penegakan diagnosis pada pasien dengan mikosis profunda adalah untuk mengidentifikasi penyebab, menentukan tatalaksana tepat dan mencegah komplikasi.