bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors of severe hypoglycemia among patients with type 2 diabetes mellitus in outpatient clinic of tertiary hospital in Indonesia
Authors: Yunir Em , Nugraha Antonius R. A. , Rosana Martha , Kurniawan Juferdy , Iswati Eni , Sarumpaet Angela , Tarigan Tri Juli Edi , Tahapary Dicky L. 
Published: September 2023

AbstractThis study aimed to describe risk factors of severe hypoglycemia in type 2 diabetes mellitus (T2DM) patients in a tertiary care hospital in Indonesia. This study was a retrospective cohort study in the Endocrinology Outpatient Clinic of Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia. All subjects more than 18 years old who had been visiting the clinic for at least a year were included. Subjects were interviewed whether they had any severe hypoglycemia events within the past year, while data on risk factor variables of severe hypoglycemia was taken from medical records one year before data collection. We recruited 291 subjects, among whom 25.4% suffered at least one episode of severe hypoglycemia within one year. History of severe hypoglycemia (OR 5.864, p ≤ 0.001), eGFR less than 60 mL/min/1.73m2 (OR 1.976, p = 0.028), and insulin use (OR 2.257, p = 0.021) were associated with increased risk of severe hypoglycemia. In conclusion, history of previous severe hypoglycemia, eGFR less than 60 mL/min/1.73m2, and insulin use were associated with severe hypoglycemia.
Factors associated with palliative care symptoms in cancer patients in Palestine
Authors: Battat Maher , Omair Nawal , WildAli Mohammad A. , Alkaissi Aidah , Salameh Husam T. , Amer Riad , Koni Amer A. , Zyoud Sa’ed H. 
Published: September 2023

AbstractPalliative care is critical to redundancy in cancer patients seeking to improve their quality of life. Evaluation should be incorporated into clinical practice routines at all stages of cancer. The Edmonton Symptom Assessment System (ESAS) was used to rate the intensity of ten symptom evaluations designed and validated for cancer patients in various languages and cultures. Therefore, the study aims to assess the symptoms reported using ESAS scores to identify patients who would benefit from palliative care that can improve the integration of palliative care into standard cancer care at An-Najah National University Hospital (NNUH). A cross-sectional study was selected for 271 cancer patients using a convenience sampling method at NNUH. Demographic, clinical, and lifestyle characteristics are described. Furthermore, patients' moderate to severe symptoms (score > 4) were obtained using ESAS-R. The survey consisted of 271 patients, with a response rate of 95%. The average age of the patients was 47 ± 17.7 years, ranging from 18 to 84 years. The male-to-female ratio was approximately 1:1, 59.4% of the patients were outpatients, and 153 (56.5%) had hematologic malignancies. Fatigue (62.7%) and drowsiness (61.6%) were the most common moderate to severe symptoms in ESAS. Furthermore, pain (54.6%), nausea (40.2%), lack of appetite (55.0%), shortness of breath (28.5%), depression (40.6%), anxiety (47.2%) and poor well-being (56.5%) were reported. In conclusion, fatigue and drowsiness were the most reported symptoms according to the ESAS scale among cancer patients, while moderate to severe symptoms were reported in cancer patients using the ESAS. The ESAS is a functional tool for assessing cancer patients' symptoms and establishing palliative care services.
Association of general anesthesia exposure with risk of postoperative delirium in patients receiving transcatheter aortic valve replacement: a meta-analysis and systematic review
Authors: Ko Ching-Chung , Hung Kuo-Chuan , Chang Yang-Pei , Liu Chien-Cheng , Cheng Wan-Jung , Wu Jheng-Yan , Li Yu-Yu , Lin Tso-Chou , Sun Cheuk-Kwan 
Published: September 2023

AbstractThe aim of this meta-analysis was to assess the association of general anesthesia (GA) exposure with the risk of POD in this patient population. Databases including Medline, EMBASE, Cochrane library, and Google Scholar were searched from inception to December 2022. Analysis of 17 studies published between 2015 and 2021 involving 10,678 individuals revealed an association of GA exposure with an elevated risk of POD [odd ratio (OR) = 1.846, 95% CI 1.329 to 2.563, p = 0.0003, I2 = 68.4%, 10,678 patients]. Subgroup analysis of the diagnostic methods also demonstrated a positive correlation between GA exposure and POD risk when validated methods were used for POD diagnosis (OR = 2.199, 95% CI 1.46 to 3.31, p = 0.0002). Meta-regression analyses showed no significant impact of age, male proportion, and sample size on the correlation between GA and the risk of POD. The reported overall incidence of POD from the included studies regardless of the type of anesthesia was between 0.8 and 27%. Our meta-analysis showed a pooled incidence of 10.3% (95% CI 7% to 15%). This meta-analysis suggested an association of general anesthesia with an elevated risk of postoperative delirium, implying the necessity of implementing appropriate prophylactic strategies against this complication when general anesthesia was used in this clinical setting.
Two-dimensional tellurium-based diodes for RF applications
Authors: Askar Abdelrahman M. , Palacios Paula , Pasadas Francisco , Saeed Mohamed , Mohammadzadeh Mohammad Reza , Negra Renato , Adachi Michael M. 
Published: September 2023

AbstractThe research of two-dimensional (2D) Tellurium (Te) or tellurene is thriving to address current challenges in emerging thin-film electronic and optoelectronic devices. However, the study of 2D-Te-based devices for high-frequency applications is still lacking in the literature. This work presents a comprehensive study of two types of radio frequency (RF) diodes based on 2D-Te flakes and exploits their distinct properties in two RF applications. First, a metal-insulator-semiconductor (MIS) structure is employed as a nonlinear device in a passive RF mixer, where the achieved conversion loss at 2.5 GHz and 5 GHz is as low as 24 dB and 29 dB, respectively. Then, a metal-semiconductor (MS) diode is tested as a zero-bias millimeter-wave power detector and reaches an outstanding linear-in-dB dynamic range over 40 dB, while having voltage responsivities as high as 257 V ⋅ W−1at 1 GHz (up to 1 V detected output voltage) and 47 V ⋅ W−1at 2.5 GHz (up to 0.26 V detected output voltage). These results show superior performance compared to other 2D material-based devices in a much more mature technological phase. Thus, the authors believe that this work demonstrates the potential of 2D-Te as a promising material for devices in emerging high-frequency electronics.
Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes
Authors: Newman Jeremy R. B. , Long S. Alice , Speake Cate , Greenbaum Carla J. , Cerosaletti Karen , Rich Stephen S. , Onengut-Gumuscu Suna , McIntyre Lauren M. , Buckner Jane H. , Concannon Patrick 
Published: September 2023

AbstractGenome-wide association studies have identified numerous loci with allelic associations to Type 1 Diabetes (T1D) risk. Most disease-associated variants are enriched in regulatory sequences active in lymphoid cell types, suggesting that lymphocyte gene expression is altered in T1D. Here we assay gene expression between T1D cases and healthy controls in two autoimmunity-relevant lymphocyte cell types, memory CD4+/CD25+regulatory T cells (Treg) and memory CD4+/CD25-T cells, using a splicing event-based approach to characterize tissue-specific transcriptomes. Limited differences in isoform usage between T1D cases and controls are observed in memory CD4+/CD25-T-cells. In Tregs, 402 genes demonstrate differences in isoform usage between cases and controls, particularly RNA recognition and splicing factor genes. Many of these genes are regulated by the variable inclusion of exons that can trigger nonsense mediated decay. Our results suggest that dysregulation of gene expression, through shifts in alternative splicing in Tregs, contributes to T1D pathophysiology.
Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations
Authors: Miyazaki Isao , Odintsov Igor , Ishida Keiji , Lui Allan J. W. , Kato Masanori , Suzuki Tatsuya , Zhang Tom , Wakayama Kentaro , Kurth Renate I. , Cheng Ryan , Fujita Hidenori , Delasos Lukas , Vojnic Morana , Khodos Inna , Yamada Yukari , Ishizawa Kota , Mattar Marissa S. , Funabashi Kaoru , Chang Qing , Ohkubo Shuichi , Yano Wakako , Terada Ryuichiro , Giuliano Claudio , Lu Yue Christine , Bonifacio Annalisa , Kunte Siddharth , Davare Monika A. , Cheng Emily H. , de Stanchina Elisa , Lovati Emanuela , Iwasawa Yoshikazu , Ladanyi Marc , Somwar Romel 
Published: September 2023

AbstractRET receptor tyrosine kinase is activated in various cancers (lung, thyroid, colon and pancreatic, among others) through oncogenic fusions or gain-of-function single-nucleotide variants. Small-molecule RET kinase inhibitors became standard-of-care therapy for advanced malignancies driven by RET. The therapeutic benefit of RET inhibitors is limited, however, by acquired mutations in the drug target as well as brain metastasis, presumably due to inadequate brain penetration. Here, we perform preclinical characterization of vepafestinib (TAS0953/HM06), a next-generation RET inhibitor with a unique binding mode. We demonstrate that vepafestinib has best-in-class selectivity against RET, while exerting activity against commonly reported on-target resistance mutations (variants in RETL730, RETV804 and RETG810), and shows superior pharmacokinetic properties in the brain when compared to currently approved RET drugs. We further show that these properties translate into improved tumor control in an intracranial model of RET-driven cancer. Our results underscore the clinical potential of vepafestinib in treating RET-driven cancers.
Optimum number of cascade cells for multilevel inverter considering redundancy strategies based on cost and reliability optimization
Authors: Azimi Maede , Asadi Mehdi 
Published: September 2023

AbstractThis paper proposes an economical reliability‐oriented solution to determine the optimal number of cascade cells and redundancies for STATCOM using a Non‐Dominated Sorting Genetic (NSGA‐II) algorithm based on different redundancy configuration schemes. A multi‐objective optimization framework is presented, to minimize the total cost and maximize its reliability index by considering power quality issues. In the presented model, a new cost modelling is introduced considering the cost of inductor loss. The multilevel cascade topology with staircase modulation strategy is also taken into account. The effectiveness of the proposed optimization framework is validated by the NSGA‐II algorithm compared to the results of goal attainment and goal programming as decomposition single‐objective optimization methods. The results verify that the proposed multi‐objective optimization framework could be useful in the optimal selection of high‐voltage STATCOM levels in the presence of redundancies while ensuring the required level of reliability at the minimum cost. Also, the presented NSGA‐II optimization algorithm is applicable to maintain both objective functions at an acceptable value.
A model predictive control of three‐phase grid‐connected current‐source inverter based on optimization theory
Authors: Geng Yiwen , Zhou Tengfa , Cao Fucheng , Xin Yue , Wang Huibin 
Published: September 2023

AbstractIn the three‐phase grid‐connected current‐source inverters (CSIs), the resonance result from the AC‐side CL filter and the quality of the grid‐current waveform under the unbalanced and harmonic grid voltage conditions are two issues deserving attention. To solve the two problems, a continuous control set‐model predictive control (CCS‐MPC) method based on the optimization theory is proposed in the two‐phase synchronous coordinate frame in this paper. The constructed cost function takes grid‐connected current and output current of the inverter as control target, and obtains its optimal solution under the least‐squares method, where the optimal inverter‐side current reference is composed of inductor‐current proportional feedback, capacitor‐voltage proportional feedback, and inverter‐side current steady‐state value feedforward. The proposed method can easily realize the normal operation of three‐phase grid‐connected CSIs because the method can be determined by only one parameter under the unbalanced and distorted grids. Furthermore, in the proposed method, the proportional feedback of capacitor voltage can effectively suppress the CL filter resonance. Finally, simulation and experimental results verify the effectiveness of the proposed control strategy.
Ultra‐high gain quadratic boost DC–DC converter based on a three‐winding coupled inductor with reduced voltage stress for fuel cell‐based systems
Authors: Karimi Hajiabadi Mostafa , Mosallanejad Ali , Salemnia Ahmad 
Published: September 2023

AbstractHere, an ultra‐high gain quadratic boost DC–DC converter (UQBC) based on the conventional quadratic boost converter (CQBC) and a three‐winding coupled inductor (TWCI) has been proposed. It benefits from an extensive voltage gain range and low voltage stress on semiconductors. In addition, the converter requires a reasonable number of components. This structure is suitable for connecting renewable DC power sources like fuel cells to a DC‐bus in DC microgrids. Unlike CQBC, the produced conversion ratio has been improved to [1+n+m+d(1+n)]/(1−d)2 thanks to integrating a TWCI into CQBC. As a result, the proposed quadratic boost converter gives a better step‐up factor than previously presented quadratic boost converters (QBC). Meanwhile, the employed improvement method has not adversely affected some critical parameters like voltage stress on semiconductors or the input current ripple. This paper presents the mathematical analysis and operating principle of the proposed topology for both continuous and discontinuous current modes (CCM and DCM). Experimental results are represented to validate the converter theory and its performance. Results indicate that a high gain and efficiency have been obtained. Also, the voltage stress on the power switch is reduced by one‐fourth by choosing a proper duty cycle and winding coefficient.
Design of auto‐tuning‐based adaptive controllers for voltage source converters with inductive loads
Authors: Zhang Zheng , Shehada Ahmed , Beig Abdul R , Boiko Igor 
Published: September 2023

AbstractThis paper presents an auto‐tuning method for dc‐ac voltage source converters (VSCs) with an inductive load that is based on the modified relay feedback test (MRFT). Controllers tuned by the proposed method can produce near‐optimal dynamic performance for dc–ac VSCs without requiring knowledge of the plant's parameters. The controller consists of a PID cascaded with a digital notch filter. The tuning involves two steps. In the first step, the MRFT is used to tune the digital notch filter to compensate for the LCL resonance resulting from the LC filter's interaction with the inductive load. In the second step, one more MRFT is used to tune the PID controller using optimal tuning rules that are derived in advance (offline). The proposed optimal for the class of the dc–ac VSCs tuning rules can guarantee a specified phase margin and near optimal transient performance for any randomly picked VSC. The performance of the proposed tuning of the PID + notch filter is verified by simulations and experiments. The dynamic response of the auto‐tuned controller compares well to the response of a theoretically optimal but non‐auto‐tuned PID + notch filter designed using the full knowledge of the LC filter and the load.
Maternal Hyperglycemia Induces Autonomic Dysfunction and Heart
Failure in Older Adult Offspring
Authors: da Silva Odair Alves , Duarte Glória Pinto , Lahlou Saad 
Published: September 2023

Abstract
Aims Offspring exposed to an adverse fetal environment, such as
gestational diabetes, may manifest increased susceptibility to several chronic
diseases later in life. In the present study, the cardiovascular function of
three different ages of offspring from diabetic rats was evaluated.
Methods and results Diabetes mellitus was induced in pregnant rats by a
single dose of streptozotocin (50 mg/kg). The offspring from
diabetic (OD) and control rats (OC) were evaluated at three different ages: 6,
12 or 18 months. In the corresponding OC groups, fasting glycemia, baseline mean
arterial pressure, and sympathetic tonus increased in the OD rats at 12 (OD12)
and 18 (OD18) months of age, while cardiac hypertrophy was observed in all OD
groups. Cardiac function evaluation in vivo showed low left ventricular
systolic pressure and+dP/dt in the OD18 rats, suggesting a
systolic dysfunction. OD12 and OD18 groups showed high left ventricle
end-diastolic pressure, suggesting a diastolic dysfunction. OD groups showed an
age-related impairment of both baroreflex-mediated tachycardia and
baroreflex-mediated bradycardia in OD12 and OD18 rats. In isolated hearts from
OD18 rats, both inotropic and tachycardiac responses to increasing isoproterenol
were significantly reduced compared to the corresponding OC group.
Conclusion These results suggest that gestational diabetes triggers the
onset of hyperglycemia hypertension with impaired baroreflex sensitivity and
heart failure in older age of offspring, representing important risk factors for
death. Therefore, ensuring optimal glycemic control in diabetic pregnancy is
important and serves as a key to preventing cardiovascular disease in the
offspring in their older age.
Squash Cytology Diagnosing Plasmacytoma of Frontal Bone as First Presentation of Nonsecretory Multiple Myeloma
Authors: Nagose Vaishali B. , Patil Swapnil B. , Mahajan Neha A. 
Published: September 2023

AbstractPlasmacytoma of bone is one of the criteria for diagnosing plasma cell myeloma (multiple myeloma). A plasmacytoma involving a frontal bone is unusual, with only few being reported so far. Also, when typical clinical presentation is absent, diagnosis is usually not suspected clinicoradiologically. We report a rare case of frontal bone plasmacytoma presenting as a lump over the forehead, the squash cytology of which gave the diagnosis of neoplastic etiology. Thus, squash cytology helped in early and definitive diagnosis in this patient, hastening meticulous diagnostic investigations and appropriate management. With full workup, the final diagnosis of a nonsecretory multiple myeloma was made.
Possible Role of Mitochondrial Transfer RNA Gene 5816 A > G Genetic Polymorphism (m.5816A > G) in a 3-Year-Old Child with Dystonia: Report of a Case
Authors: Wang Sumei , Liang Minglu , Ma Jiehui , Huang Sheng , Fan Lili , Zhu Feng , Sun Dan 
Published: September 2023

Abstract
Background Mutations in the mitochondrial transfer RNA (mt-tRNA) gene are a hotspot for mitochondrial DNA (mtDNA) mutations and are most common in mitochondrial diseases.
Methods We identified the mt-tRNA gene 5816 A > G (m.5816 A > G) mutation in a 3-year-old child with dystonia who died. We performed clinical evaluation, genetic analysis, and biochemical investigation with mitochondrial function testing.
Results Our patient was found to have dystonia with hyperlactatemia. Electroencephalogram findings were abnormal in children with numerous multifocal spikes, multispike, spikes and slow waves, slow waves and low amplitude fast waves, more pronounced in the occipital region bilaterally, and occurring continuously during sleep. One year later, the preexisting patient had seizures lasting 1 to 2 hours and subsequently died. mtDNA sequencing revealed that the proband, her mother, and her grandmother all carried the m.5816A > G mutation. Oxygen consumption rate (OCR) assays revealed that the proband's basal resting OCR, adenosine triphosphate production, proton leak, maximal respiration, and spare capacity OCR were all significantly lower compared with healthy children of the same age.
Conclusion The present case demonstrates a childhood dystonia caused by a mt-tRNA gene 5816 A > G mutation, which has never been reported before. Our findings provide valuable new insights into the pathogenic mechanism and function of the m.5816A > G mutation.
The metabolic response of Araucaria angustifolia embryogenic cells to heat stress is associated with their maturation potential
Authors: Kaziuk Fernando Diego , Furlanetto Ana Luiza Dorigan de Matos , dos Santos André Luis Wendt , Floh Eny Iochevet Senegal , Donatti Lucelia , Merlin Rocha Maria Eliane , Fortes Fabiane , Martinez Glaucia Regina , Cadena Silvia Maria Suter Correia 
Published: September 2023

Araucaria angustifolia is a critically endangered species and its distribution can be affected by an increase in temperature. In this study, we evaluated the effects of heat stress (30°C) on Araucaria angustifolia cell lines responsive (SE1) and non-responsive (SE6) to the development of somatic embryos. The viability of both cell lines was reduced by heat stress and mitochondria were the organelles most affected. Heat stress for 24 h increased the reactive oxygen species (ROS) levels in SE1 cells, followed by a reduction at 48 and 72 h. In SE6 cells, an increase occurred after 24 and 48 h of stress, returning to control levels at 72 h. H2O2 levels were increased after 24 h for both SE1 and SE6 cells, being higher for SE6. Interestingly, at 48 and 72 h, H2O2 levels decreased in SE1 cells, while in SE6, the values returned to the control levels. The respiration of SE6 cells in the presence of oxidisable substrates was inhibited by heat stress, in agreement with the high lipid peroxidation levels. The AaSERK1 gene was identified in both cultures, with greater expression in the SE1 line. Heat stress for 24 and 48 h increased gene expression only in this cell line. The activity of peroxidase, superoxide dismutase and enzymes of the glutathione/ascorbate cycle was increased in both cell lines subjected to heat stress. Catalase activity was increased only in SE6 cells at 72 h of exposure. These results show that responsive SE1 cells can modulate ROS levels more efficiently than SE6 when these cells are stressed by heat. This ability may be related to the maturation capacity of these cells.
The possible impact of human activity and climate change on the potential suitable habitats of Taxus wallichianavar.mairei (Taxaceae) evaluated by ensemble modeling techniques
Authors: Wang Jiahong , Qian Qifeng , Jia XiaoJing , Yu Bing , Sun Caihua , Tao Qian 
Published: September 2023

Abstract
In the current work, we examined the possible changes in potential suitable habitats of Taxus wallichiana var. mairei (Taxaceae) under the influence of human activity and climate change using ensemble modeling techniques. T. wallichiana var. mairei is an endangered subtropical coniferous evergreen tree and is often used in medical applications. It is mainly distributed in southern China and has experienced several degenerations due to human activity in recent decades. Its growth is also very sensitive to climate change. The area of its highly suitable habitat under current climate conditions was approximately 2.31 × 106 km2, as estimated by our ensemble models, accounting for 81.85% of its total suitable habitat. The ensemble model results showed that the mean diurnal range (bio2) was the most critical environment variable affecting the performance of the ensemble models. Human activity had an overall negative influence on the suitable habitats of T. wallichiana var. mairei under current climate conditions. Under the influence of future climate change, the ensemble model predicted that the highly suitable habitat would convert to low- to medium-suitability or be lost, with the predicted loss of highly suitable habitat at the end of this century ranging from 30.40% to 96.55%. The predicted changes were more intense with increases in the severity of global warming. In addition, the ensemble model also predicted a shift in the distribution of total suitable habitats toward higher elevations. The results of this study should provide information for conservation purposes.