bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arabidopsis SMO2 modulates ribosome biogenesis by maintaining the RID2 abundance during organ growth
Authors: Guo Zhengfei , Wang Xiaoyu , Li Yan , Xing Aiming , Wu Chengyun , Li Daojun , Wang Chunfei , de Bures Anne , Zhang Yonghong , Guo Siyi , Sáez‐Vasquez Julio , Shen Zhenguo , Hu Zhubing 
Published: January 2023

SUMMARYRibosome biogenesis is a process of making ribosomes that is tightly linked with plant growth and development. Here, through a suppressor screen for the smo2 mutant, we found that lack of a ribosomal stress response mediator, ANAC082 partially restored growth defects of the smo2 mutant, indicating SMO2 is required for the repression of nucleolar stress. Consistently, the smo2 knock‐out mutant exhibited typical phenotypes characteristic of ribosome biogenesis mutants, such as pointed leaves, aberrant leaf venation, disrupted nucleolar structure, abnormal distribution of rRNA precursors, and enhanced tolerance to aminoglycoside antibiotics that target ribosomes. SMO2 interacted with ROOT INITIATION DEFECTIVE 2 (RID2), a methyltransferase‐like protein required for pre‐rRNA processing. SMO2 enhanced RID2 solubility in Escherichia coli and the loss of function of SMO2 in plant cells reduced RID2 abundance, which may result in abnormal accumulation of FIBRILLARIN 1 (FIB1) and NOP56, two key nucleolar proteins, in high‐molecular‐weight protein complex. Taken together, our results characterized a novel plant ribosome biogenesis factor, SMO2 that maintains the abundance of RID2, thereby sustaining ribosome biogenesis during plant organ growth.
Trade liberalisation and trade and capital flows: Evidence from China pilot free trade zones
Authors: Bao Te , Dai Yun , Feng Yanxiang , Liu Shuai , Wang Ruixin 
Published: January 2023

AbstractChina established several Pilot Free Trade Zones (PFTZs) in recent years as a major step to deepen trade liberalisation. In this paper, we investigate the impact of free trade zones (FTZs) on the economy's capital flow, imports and exports, as well as the underlying mechanisms. We consider the newly established FTZs as a natural experiment and construct a difference‐in‐difference (DID) model with the staggered establishment dates of the FTZs. Our results show that FTZs promote local foreign direct investment (FDI) and outward foreign direct investment (OFDI), but their influence on goods exports and imports remains limited.
The European Union and within‐country income inequalities. The case of the new member states
Authors: Serwach Tomasz 
Published: January 2023

AbstractAlthough addressing income inequalities is one of the main challenges in the European Union (EU), whether the EU has influenced income distributions, possibly causing a rise in inequalities, is still a heavily underexplored topic. Using the newest methodological developments associated with the counterfactual estimations, I assessed the distributional effects of the 2004 EU enlargement. The results indicate that EU accession cannot be held responsible for any significant changes in income inequalities in the New Member States. That finding is robust to changes in the method of estimation, and it is also supported by dynamic panel data methods.
The Arinkin–Gaitsgory temperedness conjecture
Authors: Færgeman Joakim , Raskin Sam 
Published: January 2023

AbstractArinkin and Gaitsgory defined a category of tempered ‐modules on that is conjecturally equivalent to the category of quasi‐coherent (not ind‐coherent!) sheaves on . However, their definition depends on the auxiliary data of a point of the curve; they conjectured that their definition is independent of this choice. Beraldo has outlined a proof of this conjecture that depends on some technology that is not currently available. Here we provide a short, unconditional proof of the Arinkin–Gaitsgory conjecture.
Water Relief Through Safety or Relief Valves is not Just a Leak
Authors: Miranda Samuel 
Published: January 2023

Abstract
Two Nuclear Safety Advisory Letters (NSALs), advise operators of PWRs that they may assume, in accident analyses, that certain safety and relief valves can open, relieve water, and then reseat properly. The NSALs claim water that exits the reactor coolant system (RCS) can be made up by water that is delivered into the RCS by the emergency core coolant system (ECCS). For example, during an inadvertent operation of the ECCS (IOECCS) event, The NSALs claim, “since the cause of the water relief is the ECCS flow, the magnitude of the leak will be less than or equivalent to that of the ECCS (i.e., operation of the ECCS maintains RCS inventory during the postulated event and establishes the magnitude of the subject leak).” A comparison of ECCS flow to water relief, at relevant RCS pressures, indicates that water relief, during an IOECCS, cannot be dismissed as a leak. Critical flow calculations indicate that ECCS flow cannot replace RCS inventory that is relieved, as water, through the pressurizer relief and safety valves when RCS pressures are near nominal operating levels. At much lower pressures, the ECCS could offset the water relief. However, by then the IOECCS will have been either resolved, or will have developed into a loss of coolant accident (LOCA). The NSALs were published in 1993 and 2007. NRC did not question the NSALs’ advice until 2015, when it was found in a licensee’s application for a power uprating. The licensee might have submitted a false statement, in support of its application.
Estimation of Out-of-Plane Effective Thermal Conductivity of Wire Mesh Using 3D Unit-Cell Model Incorporating Secondary Effects
Authors: Jayachandran S. , Reddy K. S. 
Published: January 2023

AbstractThis study proposes a modified collocated parameter model to estimate the effective thermal conductivity (keff) of two-phase wire mesh materials. The study focused on the influence of parameters, primary as well as secondary, on the effective thermal conductivity of a wire mesh, namely, thermal conductivity ratio (α), concentration (γa), mesh number (M), and thermal contact conductance at the wire-to-wire interfacial area were all investigated in detail over a different temperature range in the normal to the wire mesh. The analytical expressions for effective thermal conductivity in the form of algebraic equations were derived by adopting the solid square cylinder unit-cell-based thermal resistance method for a three-dimensional spatially in-line touching periodic medium. The effective thermal conductivities of different wire mesh materials with solid–fluid combinations, possessing conductivity ratios of 1–10,000 and concentrations of 0–0.8, are predicted for various temperatures at constant pressure regimes using the developed model. Furthermore, the developed model was applied to estimate the effective thermal conductivities of brass and stainless-steel wire mesh, which are compared with values measured using the modified transient plane source (MTPS) instrument over the temperature range 283–460 K. For the brass and stainless-steel mesh—water, silicone oil, and air combinations, the estimated values of effective thermal conductivity obtained from the present model show an average deviation of fluids ± 2.6%, with air ± 4.4% in the z-direction, respectively, concerning the ones obtained from the experiments.
Intraindividual Relationships Between Training Loads and Heart-Rate Variability in High-Level Female Futsal Players: A Longitudinal Study
Authors: Nakamura Fábio Y. , Costa Júlio A. , Travassos Bruno , Ortuño Daniel , Pino-Ortega José 
Published: January 2023

Purpose: To investigate the internal training loads of a professional Spanish female futsal team throughout 26 weeks of training including preseason and in-season weeks and verify the impact of training period and/or training load magnitudes on heart-rate variability responses. Furthermore, we aimed to assess, intraindividually, the relationship between training load and the coefficient of variation (CV) of weekly natural log of the root mean square difference of successive normal interbeat (RR) intervals (lnRMSSDCV), obtained from ∼5 measures per week, and recorded in the seated position. Methods: A within-subject design involved 12 high-level outfield female futsal players (mean [SD] age: 23.9 [3.4] y). Results: lnRMSSD was significantly lower and lnRMSSDCV was significantly higher during the preseason (weeks 1–6) compared to in-season (weeks 7–26) (P < .001). Individually, players presented moderate to large negative correlations between lnRMSSDCV and lnRMSSD during the 26 weeks of observation. Correlations ranged between rplayer4 = −.41 (95% CI, −.69 to −.02) and rplayer12 = −.55 (−.78 to −.18). Players also presented moderate to very large positive correlations between lnRMSSDCV and session rating of perceived exertion. Correlations ranged between rplayer7 = .41 (.04 to .71) and rplayer1 = .71 (.45 to .86). Conclusion: Professional female futsal players in this study presented increased lnRMSSD and reduced lnRMSSDCV during 20 weeks into the competitive season compared to 6 weeks of preseason. Furthermore, lnRMSSDCV was negatively associated with lnRMSSD on an intraindividual basis. Finally, higher internal training loads were positively correlated with lnRMSSDCV, indicating that heart-rate variability is responsive to weekly training loads.
Use of Accelerometers to Track Changes in Stepping Behavior With the Introduction of the 2020 COVID Pandemic Restrictions: A Case Study
Authors: McGuire Tiereny , Devin Kirstie , Patricks Victoria , Griffiths Benjamin , Speirs Craig , Granat Malcolm 
Published: January 2023

Introduction: The COVID-19 lockdown introduced restrictions to free-living activities. Changes to these activities can be accurately quantified using combined measurement. Using activPAL3 and self-reports to collect activity data, the study aimed to quantify changes that occurred in physical activity and sedentary behavior between prelockdown and lockdown. The study also sought to determine changes in indoor and outdoor stepping. Methods: Using activPAL3, four participants recorded physical activity data prelockdown and during lockdown restrictions (February–June 2020). Single events (sitting, standing, stepping, lying) were recorded and analyzed by the CREA algorithm using an event-based approach. The analysis focused on step count, sedentary time, and lying (in bed) time; median and interquartile range were calculated. Daily steps classified as taking place indoors and outdoors were calculated separately. Results: 33 prelockdown and 92 in-lockdown days of valid data were captured. Median daily step count across all participants reduced by 14.8% (from 5,828 prelockdown to 4,963 in-lockdown), while sedentary and lying time increased by 4% and 8%, respectively (sedentary: 9.98–10.30 hr; lying: 9.33–10.05 hr). Individual variations were observed in hours spent sedentary (001: 8.44–8.66, 002: 7.41–8.66, 003: 11.97–10.59, 004: 6.29–7.94, and lying (001: 9.69–9.49, 002: 11.46–11.66, 003: 7.63–9.34, 004: 9.7–11.12) pre- and in-lockdown. Discrepancies in self-report versus algorithm classification of indoor/outdoor stepping were observed for three participants. Conclusion: The study quantitively showed lockdown restrictions negatively impacted physical activity and sedentary behavior; two variables closely linked to health outcomes. This has important implications for public health policies to help develop targeted interventions and mandates that encourage additional physical activity and lower sedentary behavior.
The Perspectives of Preservice Kinesiology Students Concerning Autism and Physical Activity: Differences by Adapted Physical Activity Exposure
Authors: Hauck Janet , Felzer-Kim Isabella 
Published: January 2023

Background: This study investigated the effect of an adapted physical activity (APA) course on knowledge and perceptions of preservice trainees regarding physical activity (PA) and autism spectrum disorder in 3 areas: knowledge/perspectives, importance and ease of improving developmental domains, and importance and ease of improving motor skills. Methods: Four hundred upper-level undergraduate students were recruited to participate in this survey-based study (251 APA students and 149 non-APA students participated). Survey data were analyzed using multivariate analyses of variance. Results: Participants estimated that the moderate to vigorous PA recommendations are 39.34 minutes per day, that 46.65% of moderate to vigorous PA occurs during school, and that 61.03% of children have motor difficulties. Participants perceived activities of daily living, sleep habits, and heart health as the easiest domains to improve, and problem behaviors, social skills, and self-esteem as the most difficult domains to improve. Knowledge/perspectives regarding autism spectrum disorder and PA were different by APA exposure (F12,324 = 3.11, P < .001). Differences included self-efficacy in providing PA advice, knowledge of PA guidelines, and willingness to provide motor assessment referrals. Students differed by APA exposure in the importance of developmental domains (F8,381 = 4.37, P < .001) but not ease of improving those domains. Conclusion: Results suggest that APA education and contact with children with disabilities improves self-efficacy, perspectives, and knowledge of PA and motor concerns in children with autism spectrum disorder.
Metabolic fluorine labeling and hotspot imaging of dynamic gut microbiota in mice
Authors: Chen Dongxia , Guo Junnan , Li Ao , Sun Chengjie , Lin Huibin , Lin Hongyu , Yang Chaoyong , Wang Wei , Gao Jinhao 
Published: January 2023

Real-time localization and microbial activity information of indigenous gut microbiota over an extended period of time remains a challenge with existing visualizing methods. Here, we report a metabolic fluorine labeling (MEFLA)–based strategy for monitoring the dynamic gut microbiota via
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F magnetic resonance imaging (
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F MRI). In situ labeling of different microbiota subgroups is achieved by using a panel of peptidoglycan-targeting MEFLA probes containing
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F atoms of different chemical shifts, and subsequent real-time in vivo imaging is accomplished by multiplexed hotspot
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F MRI with high sensitivity and unlimited penetration. Using this method, we realize extended visualization (>24 hours) of native gut microbes located at different intestinal sections and semiquantitative analysis of their metabolic dynamics modulated by various conditions, such as the host death and different β-lactam antibiotics. Our strategy holds great potential for noninvasive and real-time assessing of the metabolic activities and locations of the highly dynamic gut microbiota.
Orbital and periocular complications in patients with sinonasal tumours with orbital invasion
Authors: Zhao Jiawei , Jiang Xinyang , Hanna Ehab , Su Shirley Y , Moreno Amy , Gunn Brandon , Frank Steven Jay , Ferrarotto Renata , Ning Jing , Esmaeli Bita 
Published: January 2023

AimsThe purpose of this study was to determine the frequency and associated risk factors of orbital/periocular complications in patients with sinonasal tumour with orbital invasion managed with eye-sparing treatments.MethodsA retrospective case series of patients with primary sinonasal tumour with orbital invasion from January 2008 to December 2018. Patient factors were compared between the following groups: (1)patients with orbital/periocular complications versus those who did not and (2) patients who needed secondary oculoplastic surgical procedures versus those who did not.ResultsOut of 80 patients, 48 had eye-sparing surgery, 8 had orbital exenteration and 24 were managed non-surgically. The most common histology was squamous cell carcinoma (n=28, 35%). Among the eye-sparing treatment group, 51/72 patients experienced one or more orbital/periocular complication(s), with motility deficit (N=26, 36%) being the most frequent. Factors associated with higher risk of complications included tumour involving the orbital floor (p=0.019), clinical disease stage III/IV (p=0.038), maxillectomy (p=0.004), resection of the orbital floor (p=0.027) and cigarette smoking (p=0.041). Tumour involving the orbital floor had an OR of 3.9 (95% CI 1.3 to 11.6, p=0.016) in predicting orbital/periocular complication. In the eye-sparing surgery group, the most frequent secondary oculoplastic procedures was dacryocystorhinostomy (n=6, 13%). The use of a free flap in reconstruction had an OR of 8.2 (95% CI 2.1 to 31.8, p=0.002) in predicting need for secondary oculoplastic surgery.ConclusionMajority of patients with sinonasal tumours and secondary orbital invasion were managed with eye-sparing multidisciplinary treatments. Preservation of the eye can lead to reasonably good functional outcome despite expected orbital and periocular complications.
Invasive validation of the Antares algorithm for determining central blood pressure based on upper arm oscillometric pulse waves in patients with type 2 diabetes
Authors: Stäuber Alexander , Piper Cornelia , Köster Marco , Dörr Marcus , Richter Stefan , Ohlow Marc-Alexander , Eckert Siegfried , Baulmann Johannes 
Published: January 2023

IntroductionAntares is a pulse wave analysis (PWA) algorithm designed to allow a non-invasive estimation of central (aortic) blood pressure (cBP) using automated oscillometric blood pressure (BP) devices. Diabetes may affect elastic and muscular arteries differently, resulting in disparate pulse wave characteristics in central and peripheral arteries, which may limit the accuracy of PWA devices. The aim of our study was to evaluate the accuracy of Antares for estimating cBP as compared with invasively measured cBP in patients with type 2 diabetes.Research design and methodsIn this study, consecutive patients undergoing elective coronary angiography were recruited between November 2017 and September 2020. In 119 patients with type 2 diabetes, cBP was measured invasively and simultaneously determined non-invasively using the custo screen 400 device with the integrated Antares algorithm.ResultsThe mean difference between the estimated and invasively measured cBP was 1.2±6.3 mmHg for central systolic BP (cSBP), 1.0±4.3 mmHg for central mean arterial pressure (cMAP) and 3.6±5.7 mmHg for central diastolic BP (cDBP). High correlations were found between estimated cBP and invasively measured cBP (cSBP: r=0.916; cMAP: r=0.882; cDBP: r=0.791; all p<0.001).ConclusionsThe present study suggests that the Antares algorithm incorporated into the custo screen 400 device can estimate cBP with high accuracy turning a conventional oscillometric BP device into a type II device for the non-invasive estimation of cBP, which is applicable in patients with type 2 diabetes. Integration of Antares into commercially available BP devices could facilitate the introduction of cBP into routine clinical practice as a part of disease and risk management.
Evidence-based practice utilisation and its associated factors among nurses working at public hospitals in West Shoa zone, central Ethiopia: a cross-sectional study
Authors: Megersa Yohanis , Dechasa Abebe , Shibru Abera , Mideksa Lema , Tura Meseret Robi 
Published: January 2023

ObjectiveThe aim of this study was to assess the utilisation of evidence-based practice (EBP) and its associated factors among nurses working in public hospitals of West Shoa zone, Oromia, central Ethiopia, in 2021.DesignInstitution-based cross-sectional study.SettingGovernment hospitals including four primary hospitals, three general hospitals and a referral hospital. The study was conducted between 10 August and 30 August 2021.Participants418 randomly selected nurses working in public hospitals of West Shoa. Data were collected via a structured, self-administered questionnaire, entered into EpiData V.3.1 and exported to SPSS V.26 for analysis.Outcome measureUtilisation of EBP (good/poor).Results52.4% (95% CI 47.6% to 57.3%) of nurses had good EBP utilisation. Level of hospital (adjusted OR (AOR) 0.456 (95% CI 0.253 to 0.821)), administrative position (AOR 2.7 (1.09 to 6.69)), level of education (AOR 0.353 (0.181 to 0.686)), knowledge about EBP (AOR 1.785, (1.13 to 2.82)), availability of time (AOR 0.523 (0.28 to 0.96)), and cooperative and supportive colleagues (AOR 0.429 (0.235 to 0.783)) were associated with good utilisation of evidence-based nursing practice.ConclusionThe utilisation of EBP among nurses is low. Level of education, knowledge about EBP, sufficient time at the workplace, and cooperative and supportive colleagues were among the factors associated with good EBP utilisation. The healthcare system in general, hospital management specifically, needs to design strategies to improve evidence-based nursing practice in the area.
Construct validity of Patient-Reported Outcomes Measurement Information System Paediatric measures in juvenile idiopathic arthritis and systemic lupus erythematosus: cross-sectional evaluation
Authors: Weitzman Elissa R , Gaultney Amy , von Scheven Emily , Ringold Sarah , Mann Courtney M , Magane Kara M , Lin Li , Leverty Renee , Dennos Anne , Hernandez Alexy , Lippmann Steven J , Dedeoglu Fatma , Marin Alexandra C , Cox Rachele , Reeve Bryce B , Schanberg Laura E 
Published: January 2023

ObjectivesEvaluate construct validity of Patient-Reported Outcomes Measurement Information System (PROMIS) Paediatric measures of symptoms and functioning against measures of disease activity among youth with juvenile idiopathic arthritis (JIA) or systemic lupus erythematosus (SLE).DesignCross-sectional associations among PROMIS measures and clinical metrics of disease activity were estimated.SettingSeven clinical sites of the Childhood Arthritis and Rheumatology Alliance (CARRA) in the USA.ParticipantsYouth aged 8–17 years enrolled in the CARRA Registry.InterventionPROMIS measures were collected and associations with clinical measures of disease activity estimated, by condition, in bivariate and multivariable analyses with adjustment for sociodemographics, insurance status, medications and disease duration.Main outcome measuresPROMIS Paediatric measures of mobility, physical activity, fatigue, pain interference, family relationships, peer relationships, depressive symptoms, psychological stress, anxiety, and meaning and purpose, and clinical metrics of disease.ResultsAmong 451 youth (average age 13.8 years, 71% female), most (n=393, 87%) had a JIA diagnosis and the remainder (n=58, 13%) had SLE. Among participants with JIA, those with moderate/high compared with low/inactive disease had, on average, worse mobility (multivariable regression coefficient and 95% CIs) (−7.40; −9.30 to –5.50), fatigue (3.22; 1.02 to 5.42), pain interference (4.76; 3.04 to 6.48), peer relationships (−2.58; −4.52 to –1.64), depressive symptoms (3.00; 0.96 to 5.04), anxiety (2.48; 0.40 to 4.56) and psychological stress (2.52; 0.68 to 4.36). For SLE, youth with active versus inactive disease had on average worse mobility (−5.07; −10.15 to 0.01) but PROMIS Paediatric measures did not discriminate participants with active and inactive disease in adjusted analyses.ConclusionsSeven PROMIS Paediatric measures discriminated between active and inactive disease in youth with JIA. Results advance the usefulness of PROMIS for understanding well-being and improving interventions for youth with JIA, but larger studies are needed to determine utility in SLE cohorts.Trial registration numberNational Institute of Arthritis and Musculoskeletal and Skin Diseases (U19AR069522).