bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Life of people with Schizophrenia: A meta-analysis
Authors: Attepe Özden Seda , Tekindal Melike , Tekindal Mustafa Agah 
Published: April 2023

Background: Schizophrenia is a severe, chronic mental disorder that causes many psychosocial problems. In order to reveal these problems, it is necessary to measure the quality of life of people with schizophrenia. Aim: The aim of this meta-analysis is to compare the quality of life of people with schizophrenia and healthy subjects. Methods: Literature search was conducted in the Web of Science Core Collection database including the dates of January 2000 and March 2021. The systematic search provided 464 potentially relevant studies. The final sample consisted of 18 studies. Results: The results of using a random effects model for analysis indicated that schizophrenia subjects showed considerably lower quality of life scores compared to healthy controls. Conclusion: Determining the quality of people with schizophrenia will help us to create effective psychosocial intervention programs.
Researcher Views of Barriers to Clinical and Translational Research in a Statewide Program
Authors: Kimberly Judy A. , Kogut Stephen , Stevenson John F. , Fede Jacquelyn , Hayward Anthony R. , Tenca Meghan E. 
Published: April 2023

The Tracking and Evaluation Core of Rhode Island Advance-CTR conducted an online needs assessment survey at the program’s inception in 2016 and again in 2021. Now dealing with well-established support systems provided by the grant, we were particularly interested in how the perceived needs of the research community in Rhode Island might have changed over five years. Specifically, what barriers have been reduced or eliminated and which have persisted or increased? How do those barriers vary by demographic status and what implications do those differences have for the CTR? An online survey was completed by 199 researchers, who reported the extent to which they perceived the lack of access to a range of research supports as a barrier to conducting research at their institution. Overall, researchers indicated statistically significant changes from 2016 to 2021 such that a lack of pilot project funding and proposal development support had decreased as barriers, while space for research, and advice on commercial development, had increased. Statistically significant differences in the salience of particular barriers by some demographic variables were also noted and the results of this study suggest Centers for Clinical and Translational Research can have salutary effects on the research paradigm within their partnering institutions in a relatively short time.
The compressive performances of 3D-printed micron-size corrugated sandwich structures
Authors: Ji Lijun , Liu Weilin , Gong Wensheng , Qin Xiang , Liu Lingling , Luo Liping 
Published: April 2023

Micron-scale grid-shaped, V-shaped and U-shaped corrugated sandwich structures are fabricated by 3D printing technology and present different mechanical properties from those made by traditional method. Their peak stresses and elastic moduli could be fitted to cubic functions. The compression performance of the multilayer grid-shaped sandwich can be determined by the relative mechanical strength of layers. Adding a layer on a grid-shaped sandwich has no significant influence on the peak stress, but can enhance the elastic modulus by about 60.9 MPa. The deformation modes of multilayer V-shaped and U-shaped sandwiches can be determined by the load carrying path and the relative mechanical properties between interlayers and cores. The elastic modulus of V-shaped sandwich is enhanced with the increase of layer number, while the elastic modulus of U-shaped sandwich decreases with the increase of layer number. The peak stress and the elastic modulus of a four-layer V-shaped sandwich can reach 9.85 MPa and 261.09 MPa, and those of a four-layer U-shaped sandwich can reach 4.79 MPa and 119.18 MPa. The result reveals the principles that the reduced structural size and suppressed debonding, the structures and the load carrying path, and materials, influence the failure mode and mechanical properties of the corrugated sandwiches.
An arterial access system for targeted chemotherapy delivery and arterial-arterial extracorporeal recirculation for ‘end stage’ peripheral vascular disease
Authors: Lane Rodney J , Keogh Sarah E , Khin Nyan Y 
Published: April 2023

Background: Vascular access via a single arterial catheter for targeted chemotherapy delivery has difficulties with concentration, dilution, drug retention, plasma binding, and lack of control of the tumour microcirculation. An implantable arterial access system to accommodate multi-catheter access was developed address these problems. The system was also adapted for isolated arterial-to-arterial extracorporeal suprasystolic perfusion for end stage peripheral vascular disease. The arterial-to-arterial logistics were compared with standard venovenous and arteriovenous fistulae access employed in haemodialysis. Methods: Targeted chemotherapy delivery was addressed in a pilot study of vascular liver isolation. Ten patients with secondary colorectal cancer, were treated with multiple infusions employing up to five individually steered catheters. The arterial-to-arterial extracorporeal access system was also used to treat end stage peripheral vascular disease in 20 patients where amputation was the only option. The trial was named Hypertensive Extracorporeal Limb Perfusion (HELP). Results: Multiple day only infusions produced a partial response or stable disease in six out of the ten patients in an ‘end stage’ setting. The mean survival was 11.2 months. Of the twenty patients facing amputation 40% had avoided amputation at follow-up 22 months and 20% had delay of 4 months. Conclusion: The access system allows repeatable steerable multi-catheter arterial access for chemotherapy delivery to address difficulties of concentration, dilution, plasma binding and microvascular control. The access system supports multiple repeatable suprasystolic extracorporeal arterial to arterial access. It is cardiac independent generating flows of greater than 1 L/min with zero flow in between treatments. The device logistics compares favourably with arteriovenous and venovenous access systems.
A Scoping Review of Risk and Protective Factors for Negative Cannabis Use Consequences
Authors: Grigsby Timothy J. , Lopez Andrea , Albers Larisa , Rogers Christopher J. , Forster Myriam 
Published: April 2023

Objective: Numerous reviews have examined risk and protective factors for alcohol-related negative consequences, but no equivalent review of risk and protective factors exists for cannabis-related negative consequences (CRNCs)-a gap filled by the present study. This scoping review examined survey-based research of risk and protective factors for CRNCs such as neglecting responsibilities, blacking out, or needing more cannabis. Methods: Three databases (PubMed, PsycINFO, and Google Scholar) were searched for peer-reviewed manuscripts published between January 1, 1990, and December 31, 2021. A qualitative synthesis was performed using the matrix method and the results were organized using the socioecological model as a framework. Results: Eighty-three studies were included in the review. There was considerable variation in measures and operationalizations of CRNCs across studies. Risk factors were identified in the intrapersonal (depression, social anxiety, PTSD, impulsivity, sensation seeking, motives, expectancies), interpersonal/community (trauma, victimization, family and peer substance use, social norms), and social/policy (education, employment, community attachment, legalization, availability of substances) domains of influence. Protective behavioral strategies were a robust protective factor for CRNCs. Males consistently reported more CRNCs than females, but there were no differences observed across race. Conclusions: Future research should identify person- and product-specific patterns of CRNCs to refine theoretical models of cannabis misuse and addiction. Public health interventions to reduce the risk of negative consequences from cannabis should consider utilizing multilevel interventions to attenuate the cumulative risk from a combination of psychological, contextual, and social influences.
Management of vascular risk in people with multiple sclerosis at the time of diagnosis in England: A population-based study
Authors: Palladino Raffaele , Marrie Ruth Ann , Majeed Azeem , Chataway Jeremy 
Published: April 2023

Background: Vascular management in People with Multiple Sclerosis (PwMS) is important given the higher vascular burden than the general population, associated with increased disability and mortality. Objectives: We assessed differences in the prevalence of type 2 diabetes and hypertension; and the use of antidiabetic, antihypertensive and lipid-lowering medications at the time of the MS diagnosis. Methods: This is a population-based study including PwMS and matched controls between 1987 and 2018 in England. Results: We identified 12,251 PwMS and 72,572 matched controls. PwMS had a 30% increased prevalence of type 2 diabetes (95% confidence interval (CI) = 1.19, 1.42). Among those with type 2 diabetes, PwMS had a 56% lower prevalence of antidiabetic usage (95% CI = 0.33, 0.58). Prevalence of hypertension was 6% greater in PwMS (95% CI = 1.05, 1.06), but in those with hypertension, usage of antihypertensive was 66% lower in PwMS (95% CI = 0.28, 0.42) than controls. Treatment with lipid-lowering medications was 63% lower in PwMS (95% CI = 0.54, 0.74). PwMS had a 0.4-mm Hg lower systolic blood pressure (95% CI = −0.60, −0.13). 3.8% of PwMS were frail. Conclusion: At the time of diagnosis, PwMS have an increased prevalence of vascular risk factors, including hypertension and diabetes though paradoxically, there is poorer treatment. Clinical guidelines supporting appropriate vascular assessment and management in PwMS should be developed.
Self-care management among children and adolescents with diabetes mellitus in Malaysia
Authors: Mohd Nor Noor Shafina , Anuar Zaini Azriyanti , Jalaludin Muhammad Yazid 
Published: April 2023

The study aimed to evaluate diabetes self-care among diabetic children and adolescents and compare with glycaemic control. Summary of Diabetes Self-Care Activities (SDSCA) questionnaire was distributed to patients aged 10–18 years with types 1 and 2 diabetes mellitus (DM) at paediatric diabetes clinics in Malaysia. Haemoglobin A1c levels were measured after questionnaire completion. A total of 106 patients completed the questionnaire with a mean age of 13.91 (± SD 2.48) years. Mean haemoglobin A1c and SDSCA score were 9.78 (± SD 2.43)% and 19.09 (± SD 5.81), respectively. Type 1 DM patients had significantly higher haemoglobin A1c (10.11 95% CI [9.62, 10.59] vs 8.38 95% CI [7.13, 9.62]). Total score was higher in type 1 DM although not statistically significant (19.32 95% CI [18.21, 20.43] vs 18.08 95% CI [14.28, 21.87]). Blood glucose testing score was significantly higher in type 1 DM (5.24 95% CI [4.82, 5.66] vs 3.50 95% CI [2.23, 4.77]). There was statistically significant negative correlation between score in diet subcategory and haemoglobin A1c. In conclusion, self-care activities among diabetic children and adolescents are still suboptimal. Self-care activities on blood glucose testing are significantly better in type 1 DM. Diet section correlated well with glycaemic control necessitating further research.
Early Experience of Inner Branch Retrograde Cannulation With E-nside Branch Stent Graft for Thoracoabdominal Aortic Aneurysms
Authors: Spinella Giovanni , Pane Bianca , Finotello Alice , Bastianon Martina , Mena Vera Jorge Miguel , Di Gregorio Sara , Pratesi Giovanni 
Published: April 2023

Purpose: The aim of our study is to investigate the feasibility of retrograde cannulation using devices with inner branches (IB) for the endovascular treatment of thoracoabdominal aortic aneurysms (TAAAs). Materials and Methods: A retrospective analysis using IB configuration with retrograde cannulation was carried out on TAAAs patients undergoing endovascular treatment. Results: Seven patients underwent IB endovascular treatment with retrograde cannulation between September 2020 and November 2021. The mean age was 80.4 years and 4 patients were male. A total of 26 of 28 target vessels were cannulated by retrograde access with a technical success of 93% (2 of 26 target vessels). Two intra-procedural complications were observed (1 renal artery dissection and 1 collateral renal artery rupture). In total, 26 of 28 treated vessels were retrograde cannulated with a technical success of 93%. A total of 39 stent bridges were used (all Viabahn VBX devices). The mean duration of the procedure was 321±102 minutes, and the mean scan time was 134±62 minutes. Mortality at 30 days was observed in 1 case. During the follow-up, 1 stent bridge occlusion was observed without the need for reintervention. Conclusion: Retrograde cannulation can also be successfully performed in the case of inner branches. Clinical Impact In inner branched cases, retrograde cannulation should be taken into consideration in particular cases or it could become the option of choice. Dedicated endovascular material available such as steerable catheters and latest generation covered stents is fundamental for the success of the treatment.
Reducing Anxiety and Dyspnea via Device-Guided Breathing (RELAX): A Multi-Site Feasibility Study in Post-Treatment Lung Cancer Survivors at Community Cancer Clinics (WF-01213)
Authors: Danhauer Suzanne C. , Dressler Emily V. , Brown W. Mark , Nightingale Chandylen L. , Brenes Gretchen A. , Petty William J. , Curtis Amarinthia , Murkutla Srujitha , Huang Jocelin , Wagi Cheyenne R. , Lesser Glenn J. , Weaver Kathryn E. 
Published: April 2023

Introduction: Anxiety and dyspnea are 2 common symptoms for lung cancer survivors. Although research suggests decreasing respiration rate can reduce anxiety in several populations, potential benefits of device-guided breathing have not been studied in lung cancer survivors. This feasibility study (WF-01213) provides estimates of accrual, adherence, retention, and preliminary efficacy of 2 doses of a device-guided breathing intervention versus a usual breathing control group for improving self-reported anxiety and dyspnea in post-treatment lung cancer survivors. Methods: Stage I-IV lung cancer survivors were recruited through the NCI Community Oncology Research Program (NCORP) and randomized to 12 weeks of a device-guided breathing intervention (high dose vs. low dose) or control device. Self-reported outcomes (anxiety, depression, dyspnea, cancer-related worry, fatigue) were assessed at baseline, mid-intervention (Week-6), and post-intervention (Week-12). Results: Forty-six participants (ages 41-77, median = 65; 78% White) were randomized to the high-dose intervention (n = 14), low-dose intervention (n = 14), or control (n = 18) groups between July 2015 and September 2019. Study accrual rate was 0.92 per month for 50 months (projected accrual was 6.3/month). Fourteen participants (30%) withdrew early from the study, with almost half of those discontinuing at or immediately following baseline assessment. No participants were adherent with the intervention per protocol specifications. The proportion minimally adherent (using device at least 1x/week) was 43% (6/14), 64% (9/14), and 61% (11/18) for high-dose, low-dose, and control groups, respectively. Anxiety significantly decreased from baseline for all groups at Week 12. Adherence to the intervention was low across all treatment groups. Conclusions: This study did not establish feasibility of a community-based randomized trial of 2 doses of device-guided breathing and a control group using an identical-looking device for lung cancer survivors. In both the high-dose and control groups, there were significant improvements from baseline for anxiety and dyspnea. In the low-dose group, there were significant improvements from baseline for anxiety and depression. Ratings and feedback on the intervention were mixed (although leaned in a positive direction). Participants reported liking the feeling of relaxation/calm, helping others, breathing awareness, and music. Participants reporting liking least finding/making time to use the device, frustration with the device, and completing study forms. Trial Registration: Clinical Trials ID: NCT02063828, clinicaltrials.gov.
Evaluating Performance of Circular Staplers Using Comparative Test Methods for Evidence-Based Surgery
Authors: Strassner Haley , Caulk Alexander , Reher Nicholas , Petrescu Stephanie , Vasanji Amit 
Published: April 2023

Background Circular stapler anastomosis is a common surgical procedure. Despite technological advancements, anastomotic leak remains a postoperative concern. Assessment of new technologies is impeded by variations in test methods and analysis, precluding outcome reproducibility and direct comparisons of results across studies. The development of robust and reproducible preclinical test methods is critical to accelerating stapling technology advancements. Methodology Leak pressure, staple line perfusion and security, and device removal force were quantified for triple-row (Tri-staple EEA, TriEEA) and double-row staplers (Echelon Circular Powered, ECP). Leak and perfusion testing were performed in vivo. Device removal force and staple line security testing were performed with synthetic medium using an Instron. Data were analyzed using unpaired student’s t-test or Kruskal-Wallis test, with statistical significance defined as P < .05. Results Leak pressure was 73% higher in TriEEA vs ECP ( P = .016). TriEEA staple line failure force was lower than ECP at 40 and 50 mmHg ( P = .001 and P = .023, respectively). Perfusion to the staple line was higher (148%) for TriEEA than for ECP ( P = .003) and the force required to remove the device from its stapled anastomosis was 78% lower for TriEEA than for ECP ( P < .001). Discussion/Conclusions This report addresses a primary limitation in stapling research by presenting novel methodologies which enhance clinical relevance and provide sufficient detail for reproduction by independent investigators. These methods are applied to a comparison between triple-row and double-row staplers to demonstrate utility of new test methods in assessing key technology design features.
Friendship theory for public health research and practice: a critical realist review
Authors: Doran D , Edgley A 
Published: April 2023

Aims: To critically analyse theories of friendship through privileging research on the experience of friendship among those who have experienced mental ill-health. To inform public health approaches that aim to facilitate friendship and assist those experiencing mental ill-health. Method: A selective, iterative, purposive review of theoretical and empirical studies, within a critical realist epistemology, is undertaken to provide an analysis. Results: Existing theories – exchange and equity, capital, identity, and attachment – all provide some insight into friendship when encountering mental ill-health. However, recognition theory is found to best capture and explain the experience. Conclusion: Recognition theory forms a substantial theoretical foundation for public health initiatives that address friendship and mental ill-health. Friendship can contribute to public mental health, and suggestions are made to give friendship itself recognition within public health frameworks.
Effect of Postoperative Ketorolac Administration on the Union Rate Following First Metatarsophalangeal Joint Arthrodesis
Authors: Kachooei Amir , Hester William , Gaston Tara , Corr Daniel , Winters Brian , Raikin Steven , Daniel Joseph 
Published: April 2023

Background: To decrease postoperative opioid consumption, nonsteroidal anti-inflammatory drugs (NSAIDs), including ketorolac, are considered a proper substitute with few side effects. Our null hypothesis is that a standard-dose, short-term ketorolac exposure does not increase the nonunion rate of a first metatarsophalangeal joint (MTPJ) arthrodesis. Methods: In a retrospective cohort study, we included 181 primary first MTPJ arthrodeses from 2016 to 2020 in a single surgeon practice. The surgical technique was identical using a dorsal locking plate after preparing the joint with the cup-and-cone technique. A 30 mg intravenous dose of ketorolac was administered perioperatively, followed by a post-operative oral course of 10 mg oral ketorolac every 6 hours for 5 consecutive days. Patients were placed in a heel weight-bearing CAM boot for a minimum of 6 weeks. Union was determined radiographically at 3 months postoperative. Radiographic nonunion was also categorized clinically as symptomatic versus asymptomatic. Results: At 3 months postoperative, a nonunion occurred in 15 (8.3%) patients. Of the 15 radiographic nonunions, 7 (45%) were clinically asymptomatic, while the other 8 (55%) were symptomatic. Six (75%) of the 8 symptomatic nonunions ultimately underwent revision surgery. The nonunion rate in our study compared to that described in the literature (5.4%) was similar and showed no significant difference (P = .067). Conclusion: The use of a short course of oral ketorolac (40 mg/day or less for a maximum of 5 days) does not seem to affect the union rate after first MTPJ arthrodesis and can be used safely and effectively in the management of post-operative pain to decrease opioid consumption following this procedure. Levels of Evidence: Level 4
RETRACTED: Comparative evaluation of Sapindus Mukorossi extract with 17% EDTA on smear layer removal in various parts of the tooth root
Authors: Farooq Asad , Bilgrami Afreen , Faraz Syed Abul , Qazi Fazal Ur Rehman , Maqsood Afsheen , Altamash Sara , Arora Suraj , Halim Mohamad Syahrizal , Ahmed Naseer , Das Gotam , Heboyan Artak 
Published: April 2023

Objectives: This study aimed to compare the effectiveness of an experimental root canal irrigant and 17% Ethylene-di-amine tetra acetic acid for removal of the smear layer in the coronal, middle and apical portions of the root canal. Materials and methods: Ninety human single rooted maxillary and mandibular teeth were selected for this study. The teeth were randomly divided into two experimental groups and one control group as follows: Group A (Ethanolic extract of Sapindus Mukorossi), Group B (17% EDTA), and Group C (Distilled water). The root canals of all three groups were prepared with stainless steel K-files by means of the standard step-back technique and irrigated with 5.25% sodium hypo chloride. The teeth were decoronated, following the irrigation and divided longitudinally into two-halves and visualized using scanning electron microscope (SEM) for the amount of smear layer present utilizing the three-point score system. The observations were noted both before and after the treatment. Nonparametric tests were applied for the comparison and p-value ⩽ 0.05 was considered as statistically significant. Results: It was evident from that smear layer was completely removed in coronal portion of 27 out of 30 teeth in-group A. For middle and apical areas of group A, 24 and 19 teeth showed complete smear layer removal. In-group B it was found that there were 24, 21, and 3 teeth at coronal, middle and apical, areas respectively where smear layer were completely absent. Intra group comparison showed a significant difference ( p = 0.002) in smear layer removal was found for group A at coronal, middle and apical thirds. Similarly, a significant difference ( p = 0.001) was also found for group B; however heavy smear layer was found among the three parts of the canal for group C. Conclusions: Ethanolic extract of Sapindus Mukorossi have higher effectiveness in removing the smear layer from the root canal in comparison to 17% EDTA.