bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central America
Authors: Villagrán Sandoval Carlos Arturo 
Published: February 2023

Abstract
This chapter shows the different and unique story of Central America’s interaction with international law. This region is usually neglected by scholarship, even from other Latin American scholars. Yet, the subregion has witnessed a close interaction between geopolitics, domestic, and international law. In fact, it has served as a privileged vantage point for debates around non-intervention, uti possidetis, recognition of governments, inter alia. Therefore, this chapter shows that, in contrast to Mexico and South America, foreign intervention in domestic affairs has a long story in the subregion’s state-building efforts. In fact, a central trait that still lingers in the region is the widespread use of anti-corruption missions. These sort of arrangements, however, have also been prone to abuse—as can be seen clearly in the context of Cold War interventions. Nonetheless, they offer a pioneering example of early mechanisms for international dispute settlement.
Property, Territory, and Jurisdiction in Colonial Ibero-America
Authors: Herzog Tamar 
Published: February 2023

Abstract
This chapter seeks to problematize the assertion that international law is the product of empire. It briefly surveys European theories regarding property, territory, and jurisdiction, inquires on their implementation in colonial domains, ponders on the relations between what transpired on each side of the ocean, and asks whether these developments contributed to the formation of international law. Contemporary scholars sometimes suggest that international law is both Eurocentric and the product of empire. According to this portrait, this law might have germinated before Europeans began their colonial expansion, but it came of age during (and to a large degree, because of) colonialism.
Which Factors for Corporate Bond Returns?
Authors: Dang Thuy Duong , Hollstein Fabian , Prokopczuk Marcel 
Published: February 2023

Abstract
Factors related to carry, duration, equity momentum, and the term structure are the most important risk factors in corporate bond markets. From a large set of factor candidates, we condense an optimal model with a two-step approach. First, we filter out factors that do not systematically move bond prices. Second, we use a Bayesian model selection approach to determine the optimal, parsimonious model. Many prominent factors do not move prices or are redundant. We document the new model’s good performance compared to that of existing models in time-series and cross-sectional tests and analyze the economic drivers of the factors.
Patient-Reported Outcome Measures in Clinical High Risk for Psychosis: A Systematic Review
Authors: Addington Jean , Chao Amanda , Braun Amy , Miller Madeline , Farris Megan S 
Published: February 2023

AbstractA key issue in both research and clinical work with youth at clinical high risk (CHR) of psychosis is that there are clearly heterogenous clinical outcomes in addition to the development of psychosis. Thus, it is important to capture the psychopathologic outcomes of the CHR group and develop a core outcomes assessment set that may help in dissecting the heterogeneity and aid progress toward new treatments. In assessing psychopathology and often poor social and role functioning, we may be missing the important perspectives of the CHR individuals themselves. It is important to consider the perspectives of youth at CHR by using patient-reported outcome measures (PROMs). This systematic review of PROMs in CHR was conducted based on a comprehensive search of several databases and followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Sixty-four publications were included in the review examining PROMs for symptoms, functioning, quality of life, self-perceptions, stress, and resilience. Typically, PROMs were not the primary focus of the studies reviewed. The PROMs summarized here fit with results published elsewhere in the literature based on interviewer measures. However, very few of the measures used were validated for CHR or for youth. There are several recommendations for determining a core set of PROMs for use with CHR.
Coagulation management and transfusion in massive postpartum hemorrhage
Authors: Massoth Christina , Wenk Manuel , Meybohm Patrick , Kranke Peter 
Published: February 2023

Purpose of Review
Excessive bleeding during and following childbirth remains one of the leading causes of maternal mortality.

Recent findings
Current guidelines differ in definitions and recommendations on managing transfusion and hemostasis in massive postpartum hemorrhage (PPH). Insights gained from trauma-induced coagulopathy are not directly transferable to the obstetric population due to gestational alterations and a differing pathophysiology.

Summary
Factor deficiency is uncommon at the beginning of most etiologies of PPH but will eventually develop from consumption and depletion in the absence of bleeding control. The sensitivity of point-of-care tests for fibrinolysis is too low and may delay treatment, therefore tranexamic acid should be started early at diagnosis even without signs for hyperfibrinolysis. Transfusion management may be initiated empirically, but is best to be guided by laboratory and viscoelastic assay results as soon as possible. Hypofibrinogenemia is well detected by point-of-care tests, thus substitution may be tailored to individual needs, while reliable thresholds for fresh frozen plasma (FFP) and specific components are yet to be defined. In case of factor deficiency, prothrombin complex concentrate or lyophilized plasma allow for a more rapid restoration of coagulation than FFP. If bleeding and hemostasis are under control, a timely anticoagulation may be necessary.
Intravenous Dabigatran Provides Adequate Anticoagulation for Cardiopulmonary Bypass Using a Rabbit Model
Authors: Nadtochiy Sergiy M. , Stefanos Tatsiana , Angona Ronald E. , Darrow Nathan , Jones C.C.P., Karen , Feng Changyong , Algahim Mohamed , LeMoine Dana , Westcott Robin , Anderson Brian , Swartz Michael F. , Eaton Michael P. 
Published: February 2023

Background
Heparin anticoagulation has been used successfully for cardiopulmonary bypass (CPB). However, an alternative anticoagulant approach is desirable due to the cases of heparin-induced thrombocytopenia. Dabigatran provides anticoagulation for an in vitro model of simulated CPB. The current analysis tests the hypothesis that dabigatran provides sufficient anticoagulation for CPB in intact rabbits.

Methods
Nonlinear mixed effects models were used to estimate dabigatran parameters for a two-compartment pharmacokinetic model in 10 New Zealand White rabbits. A dabigatran infusion designed to maintain a plasma concentration of 90 µg/ml was run throughout CPB based on the pharmacokinetics. Animals were subjected to sternotomy and anticoagulated with IV dabigatran (six animals) or heparin (four animals). Rabbits were cannulated centrally using the right atrium and ascending aorta and CPB was maintained for 120 min. Measurement of activated clotting time, thromboelastometric reaction time, and blood gases were performed during CPB. Then, the animals were euthanized, and the brain and one kidney were removed for histology. Sections of the arterial filters were inspected using electron microscopy.

Results
The observed dabigatran concentrations during CPB were greater than the target concentration, ranging from 137 ± 40 μg/ml at 5 min of CPB to 428 ± 150 μg/ml at 60 min, and 295 ± 35 μg/ml at 120 min. All rabbits completed 2 h of CPB without visible thrombosis. In the two groups, reaction time values were elevated, reaching 10,262 ± 4,198 s (dabigatran group) and 354 ± 141 s (heparin group) at 120 min of CPB. Brains and kidneys showed no evidence of thrombosis or ultrastructural damage. Sections of the arterial line filter showed minimal or no fibrin. There was no significant difference in outcomes between dabigatran- and heparin-treated animals.

Conclusions
In this first-use, proof-of-concept study, the authors have shown that dabigatran provides acceptable anticoagulation similar to heparin to prevent thrombosis using a rabbit CPB model.

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Phase III Randomized Non-Inferiority Study of OSS Versus PEG + Electrolyte Colonoscopy Preparation in Adolescents
Authors: Socha Piotr , Posovszky Carsten , Szychta Monika , Viscogliosi Federica , Martemucci Luigi , Grzybowska-Chlebowczyk Urszula , Perrot Valerie , Kornowski Anne , Benninga Marc A. ,   on behalf of the EASYKID Study Group
Published: February 2023

Objectives:
Many protocols and preparations are used for bowel cleansing before pediatric colonoscopy but few are based on scientific evidence. We evaluated efficacy, safety, tolerability, and patient preference of oral sulfate solution (OSS) at 75% of the adult dose versus polyethylene glycol (PEG)-electrolyte solution in adolescents presenting for diagnostic colonoscopy.

Methods:
Phase III, randomized, evaluator-blinded, non-inferiority study of OSS and PEG in adolescents aged 12–17 years. OSS and PEG were administered in 2 doses on the day before colonoscopy. Primary endpoint included proportion of patients with successful overall preparation (4-point scale). Secondary endpoints included overall and segmental bowel cleansing (Boston Bowel Preparation Scale; BBPS), completed colonoscopies, duration of examination, time to cecal intubation, proportion of nasogastric tubes (NGTs), adverse events (AEs) and acceptability.

Results:
Successful cleansing was achieved in 71.4% and 79.0% of patients receiving OSS and PEG, respectively [adjusted difference −7.61 (95% confidence interval, CI, −18.45 to 3.24); P = 0.0907]. Segmental BBPS score for the left and transverse colon were similar between treatment groups, but better for the right colon with PEG than OSS [2.2 (95% CI, 2.0–2.4) and 1.9 (95% CI, 1.7–2.1), respectively; P = 0.0015]. Significantly fewer OSS patients needed NGT placement to ingest the whole solution [9/125 (7.2%)] than PEG patients [36/116 (31.0%); P < 0.0001]. Treatment acceptability was significantly higher with OSS than PEG (P < 0.0001). Duration of examination, completed colonoscopies, and time to cecal intubation were similar between preparations. Gastrointestinal AEs including nausea, vomiting, abdominal pain, and distension were similar in both groups but more patients receiving PEG had AEs assessed as incapacitating.

Conclusions:
Non-inferiority of OSS to PEG was not demonstrated, but OSS was associated with a lower requirement for NGT, better acceptability, and less frequent severe AEs than with PEG.
Alzheimer’s Disease Neuropathologic Change and Vitamin Supplement Use Decades Earlier
Authors: Paganini-Hill Annlia , Bukhari Syed , Montine Thomas J. , Corrada Maria M. , Kawas Claudia H. 
Published: February 2023

Background:
Alzheimer’s disease (AD) is the most common cause of dementia. AD neuropathologic change (ADNC) likely begins decades before clinical manifestations. One mechanism implicated in AD is oxidative stress. We explored the potential association of ADNC with antioxidant vitamin supplements taken about 30 years before death.

Methods:
The 264 brain-autopsied participants were part of The 90+ Study, a longitudinal study of aging among people aged 90+ years, and originally members of the Leisure World Cohort Study, a population-based health study established in the 1980s. Intake of supplemental vitamins A, C, and E was collected by the Leisure World Cohort Study about 30 years before ADNC assessment. Odds ratios of ADNC (intermediate/high vs. none/low) for vitamin intake were estimated using logistic regression.

Results:
The adjusted odds ratio (95% CI) of ADNC was 0.52 (0.29-0.92) for vitamin E supplements and 0.51 (0.27-0.93) for vitamin C supplements. Supplemental vitamin E intake was the first variable, after education, to enter the stepwise model. Intake of vitamin A or C did not improve the model fit.

Conclusions:
The observed association of ADNC and supplemental vitamin E intake decades earlier suggests a beneficial effect and supports further investigation into a nutritional approach to preventing AD with vitamin supplementation.
Microglial function moderates the relation between depression risk factors and depression outcomes across the life course in females
Authors: Fitzgerald Eamon , Pokhvisneva Irina , Patel Sachin , Chan Shi Yu , Tan Ai Peng , Chen Helen , Silveira Patricia Pelufo , Meaney Michael J 
Published: February 2023

AbstractBackgroundDepression has an enormous socio-economic burden and is twice as common in women compared to men. Microglia are exceptionally responsive to environmental stimuli and their phenotype differs substantially by sex. We hypothesized microglial function would moderate the relation between depression risk factors and depressive outcomes in a sex-specific manner.MethodsWe used expression quantitative trait loci and single nucleus RNA-sequencing resources to generate polygenic scores (PGS) representative of individual variation in microglial function in the fetal (GUSTO; N=239-315, and ALSPAC; N=928-1461) and adult periods (UK Biobank; N=54753-72682). We stratified our analyses by sex and tested the interaction effects of these PGS with prenatal maternal depression symptoms and adult stressors, well-characterized depression risk factors. We used internalizing (early childhood) or depressive symptoms (late childhood and adulthood) as outcomes.ResultsThe fetal microglia PGS moderated the association between maternal prenatal depressive symptoms and female offspring internalizing symptoms at 4 (GUSTO; beta=-0.25, 95%CI -0.44 to - 0.06, P=0.008) and 7 years (GUSTO; beta=-0.16, 95%CI -0.318 to -0.008, P=0.04), and depressive symptoms at 8.5-10 years (GUSTO; beta = -0.15, 95%CI = -0.25 to -0.03, P= 0.01) and 24 years (ALSPAC; beta=0.1, 95%CI 0.008 to 0.19, P=0.03). The adult microglial PGS moderated the relation between BMI (UK Biobank; beta=0.001, 95%CI 0.0009 to 0.003, P=7.74E-6) and financial insecurity (UK Biobank; beta=0.001, 95%CI 0.005 to 0.015, P=2E-4) with depressive symptoms in females. There were no significant interactions in males.ConclusionOur results illustrate an important role for microglial function in the conferral of sex-dependent depression risk.
Estimation of uncertainty in Loa loa microfilarial load by microscopy
Authors: Akpo Talagbé Gabin 
Published: February 2023

AbstractFor determine the uncertainty of reading and measurement, as well as the Pari intervals of microfilarial load or microfilaremia (mf) per millimeter of Loa loa performed by microscopy. It is important to consider the uncertainty in the measurement or reading of the Loa Loa microfilarial load for the administration of ivermectin.We review existing methods for calculating the uncertainty in the measurement of a particular quantity, with emphasis on the one proposed in GUM. The data used here come from research conducted by CRFilMT in Ebolowa and Mbalmayo in 2007 and 2010, respectively, and in the Okola health district in Cameroon in 2015. The data consist of several measurements or readings of Loa loa load on each sampled individual. The application of the GUM method to our data was done using a 2-level hierarchical model.We estimated the uncertainty and sources of variation in the measurements and readings of Loa loa microfilarial load, and provided 95% intervals for the true values (8,000 mf/mL and 30,000 mf/mL), of this load for each individual. For reading, the reading uncertainty is 3.84 with a Pari interval of [6, 723.15, 11, 264] of the 8,000 mf/mL microfilar charge and 7.45 with a Pari interval of [26, 819.55, 35, 152.09] of the 30,000 mf/mL microfilar charge. For the measurement, the reading uncertainty is 20.93 with a Pari interval of [7, 647.32, 8, 216.26] of the 8,000 mf/mL microfilar charge and 40.53 with a Pari interval of [26, 819.55, 35, 152.09] of the 30,000 mf/mL microfilar charge.
Effect of continuous anesthetic wound infusion on postoperative activity in patients who underwent midline laparotomy for gynecological diseases
Authors: Kim Min Kyung , Kim Kidong , Park Youngmi , Suh Dong Hoon , No Jae Hong , Kim Yong Beom 
Published: February 2023

AbstractObjectiveThis study aimed to assess whether continuous anesthetic wound infusion (CAWI) increases postoperative activity in patients who undergo midline laparotomy for gynecological diseases.MethodsThis was an unplanned secondary analysis of a randomized controlled trial examining the effect of an activity tracker with feedback on postoperative activity in patients who underwent midline laparotomy for gynecological diseases (NCT02025387). Of the 53 patients included in the trial (12 patients used CAWI and 41 patients did not), 11 patients with CAWI (case group) and 11 without CAWI (control group) were selected by matching the duration of surgery. We compared the postoperative activity and other endpoints between the case and control groups.ResultsThe case and control groups had similar baseline and surgical characteristics. The recovery rate on postoperative day 4 (step counts at day 4/ daily step counts at preoperative baseline) of the case group was numerically higher, but not significantly different from that of the control group (58% vs. 44%; p=0.450). Least, average and present pain on postoperative day 2 were lower in the case group than in the control group. Pain on postoperative day 5, fatigue, gas out, soft blend diet initiation, ileus, and length of hospital stay were similar between the case and control groups.ConclusionsIn this exploratory analysis, CAWI was not associated with increased postoperative activity in patients who underwent midline laparotomy for gynecological diseases.
A biosensor encompassing fusarinine C-magnetic nanoparticles and aptamer-red/green carbon dots for dual-channel fluorescent and RGB discrimination ofCampylobacterandAliarcobacter
Authors: Liu Weixing , Chi Zhe 
Published: February 2023

ABSTRACTThe diarrhea pathogensCampylobacterandAliarcobacterare similar in morphology and their resulting symptoms, making them difficult to be differentially diagnosed. Herein, we report a biosensor with two newly-synthesized modules to differentiate the genera-representative species ofC. jejuniandA. butzleri. Module 1 was fusarinine C-decorated magnetic nanoparticles; module 2 consisted ofC. jejuni-specific aptamer modified with red-emitting carbon dots (CDs) andA. butzleri-specific aptamer-modified green-emitting CDs. These two CDs had non-interfering spectra. Module 1 was used to selectively captureC. jejuniandA. butzlerifrom an un-cultured sample, and the specific CDs in module 2 would then recognize and bind to their counterpart bacteria when subjected to the collected module 1-bacteria complex. By measuring the fluorescence intensities from each CDs, the existence and abundance of each bacterium could be differentially indicated. This biosensor exhibited a wide detection range of up to 1 × 107CFU/mL and the lowest limit of detection (LOD) of 1 CFU/mL, for each bacterium. Thus, the biosensor with dual-fluorescent channels facilitated a culture-independent, ultrasensitive and discriminative detection ofC. jejuniandA. butzleri. Remarkably, this fluorescent detection could be transformed into RGB color indication to render the visual discrimination. After integrating the microfluidics, this biosensor offered RGB differentiation of the two bacteria in human stool or chicken broilers with a LOD of 5 CFU/mL and turnaround time of 65 min. This work suggested a new biosensor-based methodology for the discrimination ofCampylobacterandAliarcobacterin real samples.
Do you judge a book by its cover? Online book purchases between Japan and France
Authors: Park Jin Yong , Kim Changju , Park Soohyun , Dio Kevin 
Published: February 2023

PurposeBy adopting a cross-country analysis, this study aims to investigate how consumers' perception of book covers affects their online book purchases in terms of feelings of delight and perceived value of the book.Design/methodology/approachThe authors tested the hypotheses using a structural equation model using two countries' datasets obtained from 191 Japanese and 207 French consumers.FindingsThe perceived attractiveness of a picture/photo on a book cover can positively influence feelings of delight. Such emotion enhances a book's perceived value, resulting in active online book purchases. Furthermore, when the perceived value of a book is evident, the French are more strongly motivated to purchase books compared to Japanese consumers.Originality/valueBy simultaneously examining emotion and perceived value as an organism, the authors advance the knowledge of the relationship between book covers and online book purchases. In addition, the authors offer evidence that cross-cultural differences (between the French and Japanese) can stimulate different responses to each affective and cognitive internal state, although similar environmental stimuli are provided.
The impact of immigration on urban housing prices in Indonesia
Authors: Nurkhayati Farida , Fitrady Ardyanto 
Published: February 2023

Purpose
Rural–urban migration has led to an increase in the community’s need for housing in the migration area. The demand for housing is getting higher while the land availability does not increase so that house prices will continue to increase. This study aims to estimate the impact of immigration on urban housing prices in Indonesia.

Design/methodology/approach
This study examines the effect of immigration on urban housing prices at the city level in Indonesia by using 14 major cities data from 2012 to 2020 to build a panel data model. The model also incorporates urban economic conditions as control variables.

Findings
From the national level, the authors find that inter-regional migration has a significant and positive impact on urban housing prices. Based on the results, this paper suggested addressing the volatility of house prices through the provision of decent and affordable housing improvement to meet the growing needs and demands of the immigrant population.

Research limitations/implications
This study still has several limitations: the sample of cities used is not comprehensive enough, and the time period used is not long enough; the spatial impact on house prices is not taken into account, and the effect of migrant characteristics in each city has not been considered.

Originality/value
There is limited research on the impact of immigration on urban housing prices in city levels, especially in the case of Indonesia. In addition, recent migration is used to proxy the immigration pattern. This paper provides a valuable contribution to the empirical literature on the effect of immigration at the city level in developing countries.