bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal Dissociation of the conduction system during His/LBBP Bundle Pacing: A Case Report
Authors: Li Licheng , Jiang Fei , Xu Ning , Jiang Longfu 
Published: September 2023

Abstract

Background
Evidence of the conduction system longitudinal dissociation was rare.
Case presentation
We report a case of a third-degree atrioventricular block. During HB pacing (HBP) lead deployment, widening and splitting of HB potential and intrahisian Wenckebach phenomenon were recorded in intracardiac electrogram. Then, we began unipolar HBP at 2 V/0.5 ms.The paced QRS exhibited morphology identical to that during intrinsic rhythm, indicating selective capture of the HB. After stopping screw; three different QRS patterns were recorded at unipolar 1.3mv/0.5ms pacing. During His injury repairment, the H1-H2 interval was gradually shortened, the H1 potential was seems invisible and integrated into H potential. When LBB electrode was screwed in at 2V/0.5ms continuous pacing condition, the His lead showed obvious double potential reverse transmission (H2-H1) at the presence of S-LBBP.
Conclusion
The interesting finding in this case provided further electrophysiological evidences for longitudinal dissociation of the conduction system.
Mechanisms of Tibetan Medicine Sophora Moorcroftiana Alkaloids for Treatment of Lung Cancer based on the Network Pharmacology, Molecular Docking and cell Experimental Verification
Authors: ji peng , zhao nianshou , wu fanlin , wei yanming , laba cidan , wujin cuomu , hua yongli , yuan ziwen , yao wanling 
Published: September 2023

Abstract
Background
Leguminous Sophora moorcroftiana (SM) is a genuine medicinal material in Tibet. Many research results have reveal the Sophora moorcroftiana alkaloids (SMA), as the main active substance, have a wide range of effects, such as antibacterial, antitumor and antiparasitic effects. However, there are few reports on the inhibition of lung cancer (LC) and its inhibitory mechanism, and the pharmacological mechanism of SMA is still unclear, Therefore, exploring its mechanism of action is of great significance.
Methods
The SMA active components were obtained from the literature database. Whereas the corresponding targets were screened from the PubChem and PharmMapper database, UniProt database were conducted the correction and transformation of UniProt ID on the obtained targets. The GeneCards and OMIM databases identified targets associated with LC. Venny tools obtained the intersection targets of SMA and LC. R language and Cytoscape software constructed the visual of SMA - intersection targets – LC disease network. The intersection targets protein-protein interaction (PPI) network were built by the STRING database. The functions and pathways of the common targets of SMA and LC were enriched by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, molecular docking And A549 cells vitro experiment were performed to further validate our finding.
Results
We obtained six kinds of alkaloids in SM, 635 potential targets for these compounds, and 1,303 genes related to LC. SMA and LC intersection targets was 33, including ALB, CCND1, ESR1, NOTCH1 and AR. GO enrichment indicated that biological process of SMA was mainly involved in the positive regulation of transcription and nitric oxide biosynthetic process, and DNA-templated, etc. Biological functions were mainly involved in transcription factor binding and enzyme binding, etc. Cell components were mainly involved in protein complexes, extracellular exosome, cytoplasm and nuclear chromatin, etc, Which may be associated with its anti-LC effects. KEGG enrichment analysis showed that main pathways involved in the anti-LC effects of SMA, including pathway in cancer, non small-cell lung cancer, p53, PI3K-Akt and FOXO signaling pathways. Molecular docking analyses revealed that the six active compounds had a good binding activity with the main therapeutic targets 2W96, 2CCH and 1O96. Experiments in vitro proved that SMA inhibited the proliferation of LC A549 cells.
Conclusions
results of the present study, we have successfully revealed the SMA compounds had a multi-target and multi-channel regulatory mechanism in treatment LC, These findings provided a solid theoretical reference of SMA in the clinical treatment of LC.
Damage and weakening effects of blasting on anchored rock mass
Authors: Xu Xingliang , Lei Yongchao , Tian Suchuan , Hu Weichao , Shi Hao 
Published: September 2023

Abstract
During blasting excavation of roadways, dynamic load is an important cause of damage to anchored rock mass and threatens the reliability of anchoring structures. Through theoretical analysis and numerical simulation, we studied the propagation of blasting stress waves based on anchor strengthening and damage and weakening of anchored rock mass and obtained damage characteristics of anchored rock mass under blast loading. The research results demonstrate that anchorage can reduce parameters, such as Poisson’s ratio, initial damage to the rock mass, and the attenuation coefficient of blasting load therein. The main causes of damage are high blasting load and stress wave reflection on structural planes of fractures. Moreover, the damage coefficient decreases then stabilises before increasing as the rock mass changes from being anchored to being blasted. Damage under blasting load shows zonal characteristics: a severely damaged zone, a damage transition zone, and damage vanishing zone can be seen along the axis of a roadway. The worst damage in shallow parts influences the reliability of anchoring structures, while the damage transition zone shields the anchored rock mass from deeper damage. The research results have important theoretical and guiding significance for design of bolt anchorage systems under blast load.
Robust Regression for interval valued data
Authors: Palanisamy T. , Rajesh Adithya Narayan , Giri greeshma 
Published: September 2023

Abstract

This paper presents robust regression technique of a multiple linear regression model for interval valued data that contains outliers. The proposed technique construct two models separately for mid values and spread values of the intervals. The parameters of the model involving mid values are estimated by iterative reweighted least squares technique. The estimation of the parameters of the model involving spread is accomplished by iterative reweighted quadratic programming. The quadratic programming ensures the constraints on the parameters that they are positive. Also, the proposed work detects the outliers. We have evaluated the proposed robust regression estimation technique using a Monte Carlo simulation study and a real time data. The results show the proposed estimation technique outperforms similar existing estimation.
Mathematics Subject Classification: 62F35 . 62J05
Prediction of Resilience based on Parenting Styles and Coping Strategies in Patients with Psychosomatic Disorders
Authors: Sobhani Sogand , Jamilian Hamidreza , Paknejad Iman 
Published: September 2023

Abstract

The present research was conducted aiming at predicting the resilience based on parenting styles and coping strategies in patients with psychosomatic disorders. The statistical population of the present research consisted of all patients suffering from psychosomatic disorders who had visited medical clinics related to Medical Sciences (University) of Arak County in 2019-20. The statistical sample includes 347 women, aged 18 to 55 years-old, who were selected by available sampling. Data collection tool included Young parenting styles, Moss and Billings coping strategies questionnaire and Connor and Davidson resilience questionnaire. Pearson's correlation coefficient and multiple regression analysis were used to analyze the data. The findings showed that parenting styles (dependency, preoccupied/untransformed self) have a negative and significant relationship with resilience. Coping strategies focused on emotion, coping focused on physical restraint or physicalization of problems have a negative and significant relationship with resilience and have a positive and significant relationship with coping strategies focused on problem-solving and coping focused on cognitive evaluation. According to the findings, it can be concluded that it is possible to pave the way for increasing resilience and preventing the development of psychosomatic disorders by creating suitable conditions during the childhood, improving parent-child relationships, and by strengthening coping strategies focused on problem-solving and coping focused on cognitive evaluation.
Three Gorges Dam: Influence of water quality on the density of schistosome-transmitting Oncomelania hupensis in the Dongting Lake Area, China
Authors: Wang Jiamin , Gong Yanfeng , Tong Yixin , Jiang Honglin , Xu Ning , Yin Jiangfan , Huang Junhui , Chen Yue , Jiang Qingwu , Zhou Yibiao 
Published: September 2023

Abstract
Schistosomiasis is a severe infectious disease and snails contribute to its transmission. Many factors, including water quality, affect the distribution of snails. This study collected the data on snails and indicators related to water quality in the Dongting Lake area from the period of 1998–2014. Water quality indexes such as permanganate index (CODMn), five-day biochemical oxygen demand (BOD5), total nitrogen (TN) and total phosphorus (TP) in correction with snail density were first examined using the Mann-Kendall (M-K) test. And then a Bayesian spatial-temporal model was constructed to evaluate the effect of water quality on snail density adjusting for meteorological factors and spatial-temporal variations. The results showed that the density of snails in the Dongting Lake area was influenced by water quality. The growth and reproduction of snails were promoted at a low pollution concentration, while inhibited at a high pollution concentration. These findings might provide valuable insights for relevant authorities to monitor the quality of water environment through investigating snail density.
Using a large language model (ChatGPT) to assess risk of bias in randomized controlled trials of medical interventions: protocol for a pilot study of interrater agreement with human reviewers
Authors: Rose Christopher James , Ringsten Martin , Bidonde Julia , Glanville Julie , Berg Rigmor C , Cooper Chris , Muller Ashley Elizabeth , Bergsund Hans Bugge , Meneses-Echavez Jose F , Potrebny Thomas 
Published: September 2023

Abstract
Background
Risk of bias (RoB) assessment is an essential part of systematic reviews of treatment effect. RoB assessment requires reviewers to read and understand each eligible trial and depends on a sound understanding of trial methods and RoB tools. RoB assessment is a highly skilled task, subject to human error, and can be time-consuming and expensive. Machine learning-based tools have been developed to streamline the RoB process using relatively simple models trained on limited corpuses. ChatGPT is a conversational agent based on a large language model (LLM) that was trained on an internet-scale corpus and demonstrates human-like abilities in many areas, including healthcare. LLMs might be able to perform or support systematic reviewing tasks such as assessing RoB, which may reduce review costs, time to completion, and error.
Objectives
To assess interrater agreement in overall (cf. domain-level) RoB assessment between human reviewers and ChatGPT, in randomized controlled trials of interventions within medicine.
Methods
We will randomly select 100 individually- or cluster-randomized, parallel, two-arm trials of medical interventions from recent Cochrane systematic reviews that have been assessed using the RoB1 or RoB2 family of tools. We will exclude reviews and trials that were performed under emergency conditions (e.g., COVID-19) that may not exhibit typical RoB, as well as public health and welfare interventions. We will use 25 of the trials and human RoB assessments to engineer a ChatGPT prompt for assessing overall RoB, based on trial methods text. We will obtain ChatGPT assessments of RoB for the remaining 75 trials and human assessments. We will then estimate interrater agreement.
Results
The primary outcome for this study is overall human-ChatGPT interrater agreement. We will report observed agreement with an exact 95% confidence interval, expected agreement under random assessment, Cochrane’s 𝜅, and a p-value testing the null hypothesis of no difference in agreement. Several other analyses are also planned.
Conclusions
This study is likely to provide the first evidence on interrater agreement between human RoB assessments and those provided by LLMs and will inform subsequent research in this area.
Do we need immunobiological drugs for treating anterior autoimmune uveitis in a tertiary referral center?
Authors: Araujo Leticia Cezar , Macagnani Fernanda Lourenço , Cabianca Camila Ávila Megda , Alves Daniela Pereira Castro , Costa Lívia Laila Soares , Caldeira Maria Thereza Gomes , Vieira Amanda Alexia Rodrigues , Furtado João Marcello Fortes , Oliveira Rodrigo , Luppino-Assad Rodrigo 
Published: September 2023

Abstract

Purpose
To evaluate the use of immunobiological drugs in anterior autoimmune uveitis in patients referred by rheumatologists and ophthalmologists to an autoimmune ocular diseases clinic.
Methods
Retrospective chart analysis of anterior autoimmune uveitis cases referred to a Rheumatology-Ophthalmology collaborative unit between January 2010 and January 2021. This unit receives cases almost exclusively referred by other ophthalmologists, mainly from a Uveitis Unit, or other rheumatologists.
Results
40 patients were identified and studied. The majority were women (24, 60.0%), with a mean age of 44,8 years old (SD = 16). Many patients had no identifiable underlying systemic disease (21, 52.5%). Ten (25.0%) were associated with either ankylosing spondylitis or undifferentiated spondyloarthropathy. Other associated conditions were rheumatoid arthritis (2, 5.0%), juvenile idiopathic arthritis (5, 12.5%), reactive arthritis (1, 2.5%) and psoriatic arthritis (1, 2.5%). Twenty-seven (67.5%) of the patients presented no sign of disease activity at the time of the latest evaluation (median remission period in months 14.5, IQR 0–27.5). Of these, 19 patients (70.3%) had received conventional synthetic disease-modifying anti-rheumatic drugs (csDMARD), for the most part methotrexate (15, 78.9%) and sulfasalazine (n = 6, 31.6%). Fourteen (73.7%) used csDMARD only. Only 7 (25.9%) individuals in the remission group used immunobiological drugs (bDMARD), 3 (42.8%) of which had strictly articular disease activity as drug indication. Thus, only 14.8% of patients needed bDMARD to achieve remission. The most commonly used bDMARD were TNF-alpha antagonists, mainly adalimumab (5, 71.4%).
Conclusion
Although prospective, group-controlled studies are necessary to establish the best treatment for anterior autoimmune uveitis, this study suggests that only a small group of individuals would need an immunobiological agent to achieve, even in a population of primarily challenging cases.
SNRPG serves as a novel predictor of prognosis and tumor development for hepatocellular carcinoma by activating Wnt/β-catenin signaling
Authors: Qin Yunsheng , Zhou Zhipeng , Shi Tongdong , Sun Jian , Liu Yang 
Published: September 2023

Abstract
Background
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies with poor prognosis and high mortality. The study aimed to identify crucial genes associated with HCC prognosis and treat responses, as well as the underlying mechanisms.
Methods
mRNA and protein levels in tumor cells and tissues were detected by immunohistochemistry (IHC), qRT-PCR, and western blot. CCK-8 assay was used to assess the proliferation of HCC cells and Cell cycle status was analyzed by flow cytometer. The protein interaction between SNRPB and SNRPG was verified using Co-immunoprecipitation (Co-IP). The effects of SNRPB and SNRPG expression on tumor response to XAV939 and immune checkpoint blocking (ICB) therapies were deduced through the analysis of TIDE and genomic of the GDSC dataset.
Results
SNRPB and SNRPG were significantly up-regulated in HCC tissues than that in adjacent non-tumor tissues. HCC patients with higher expressions of SNRPB and SNRPG had poor prognoses and lower survival rates. SNRPG knockdown resulted in an obvious decrease in proliferation and EMT of HCC cells and cell cycle arrest in the G2 phase, as well as reduced protein expressions of components and targets of the Wnt/β-catenin pathway. SNRPG overexpression simultaneously with shSNRPB recovered proliferation inhibition caused by SNRPB knockdown. Importantly, the double-genes prognostic signature formed by SNRPB and SNRPG had a good prognostic value for HCC patients and was negatively associated with the responses to chemo drug XAV939 and immune checkpoint blocking (ICB) therapies.
Conclusion
SNRPG was a potential interactive tumor-promoting factor and may guide clinical chemotherapy and immunotherapy for HCC.
Patient-Reported Outcome Measures More Than Fifteen Years After Treatment of Sagittal or Metopic Craniosynostosis: A Prospective Cohort Study
Authors: Woerdeman Peter A. , Klieverik Vita M. , Cheong Alexander , Singhal Ash , Cochrane Douglas , Steinbok Paul 
Published: September 2023

Abstract
Purpose
To evaluate the long-term anthropometric measurements, cosmetic satisfaction, and other patient-reported outcome measures (PROMs) of patients who underwent surgical treatment or observation only of sagittal or metopic single-suture craniosynostosis (SSC).
Methods
A prospective study was designed for all patients diagnosed with non-syndromic sagittal and metopic craniosynostosis at the British Columbia Children’s Hospital, Vancouver, Canada, in the period July 1986 to July 2006. After a minimum of 15 years post-diagnosis, all eligible patients were invited to fill out the Craniofacial Surgery Outcomes Questionnaire (CSO-Q) and to attend a scheduled follow-up appointment for the collection of anthropometric measurements. A descriptive analysis of the cosmetic results was performed. Statistical analyses compared the differences in anthropometric measurements between treated and non-treated patients.
Results
Of the 253 eligible patients, 52 participants were willing to share patient data for use in the study. Of those 52 former patients, 36 (69.2%) filled out and returned the CSO-Q and 23 (44.2%) attended the follow-up appointment. The mean follow-up period between surgical treatment and the CSO-Q was 20.2 ± 2.5 years and between surgical treatment and the follow-up appointment was 20.9 ± 2.7 years. In patients with sagittal SSC, the mean cephalic index (CI) was significantly larger in treated than in non-treated patients (74.6 versus 69.1, p = 0.04), while the mean pupillary distance and forehead to back index were significantly smaller (pupillary distance 6.0 cm versus 6.7 cm [p = 0.04] and forehead to back index 19.6 cm versus 21.1 cm [p = 0.03]). Focusing more on the patient reported outcome measures, overall cosmetic satisfaction was found to be high (80.6%) and no differences were found between sagittal and metopic synostosis patients, nor between treated or non-treated craniosynostosis patients. Overall outcomes regarding self-esteem (RSES) and fear of negative evaluation (FNE) were comparable with population based outcomes.
Conclusion
This is the first prospective study of sagittal and metopic craniosynostosis patients regarding long-term anthropometric outcome and patient reported outcome measures, including patients who were treated surgically and those who received observation only. Although study participation two decades after initial diagnosis was difficult to obtain, our data provide a platform from which one can develop an inclusive and uniform approach to assess patients’ subjective cosmetic satisfaction using the CSO-Questionnaire and might be useful in preoperative counseling and psychosocial care for patients and their families.
The Effect of Different Elicitor Treatments on Cold Stress in V. Vinifera L. Cv. 'victoria'
Authors: Daler Selda , YAĞCI Adem , CANGİ Rüstem 
Published: September 2023

Abstract
In the study carried out as a two–year greenhouse experiment, the effects of salicylic acid (SA; 0.5, 1.0 and 2.5 mM), methyl jasmonate (MJ; 5, 10 and 15 mM) and sodium nitroprusside (SNP; 0.5, 1.0 and 1.5 mM) treatments at different concentrations against cold stress (4°C, 16 hours) in Victoria variety grapevine saplings were investigated, and the most effective concentration ranges were investigated. 1.0 mM SA was found to be the most effective treatment to promote cold stress resistance of grapevines by increasing superoxide dismutase (114.23 U.mg− 1 protein), catalase (1.024 U.mg− 1 protein) and ascorbate peroxidase (20.43 U.mg− 1 protein) enzyme activities while decreasing electrolyte leakage (14.44%) and lipid peroxidation (6.07 nmol.g− 1) levels. Moreover, 10 mM MJ and 1.0 mM SNP treatments also contributed to the improvement of the osmotic adjustment capacity of grapevines by increasing proline content (MJ, 0.185 µmol.g− 1; SNP, 0.435 µmol.g− 1) and relative water content (MJ, 90.06%; SNP, 89.78%), and decreasing electrolyte leakage (MJ, 14.71%; SNP, 16.06%) and lipid peroxidation (MJ, 4.10 nmol.g− 1; SNP, 5.96 nmol.g− 1). Additionally, principal component analysis, heatmap and comprehensive evaluation based on the analytic hierarchy process indicated that 1.0 mM SA, 10 mM MJ and 1.0 mM SNP treatments performed better than other treatments in terms of both increasing plant resistance and reducing the severity of damage. This study contains important information that can provide a reference for researchers to enhance the adaptation ability of grapevines to cold stress and can enhance the success of future studies.
Correlation of diet and micronutrients with microvascular complications of diabetes mellitus: A Mendelian randomization analysis
Authors: Pu Shengdan , Xu Yuxin , Sun Xiaotong , Tong Xuewei , Zhang Yitong , Gao Xinyuan 
Published: September 2023

Abstract
Background
Observational studies have found that dietary intake and certain micronutrients are associated with microvascular complications of diabetes. However, the exact causal relationship is unclear.
Methods
Causal associations of dietary intake and micronutrients with 2 diabetic microvascular complications (diabetic retinopathy and diabetic nephropathy) were explored using two-sample Mendelian randomization analyses, respectively. Genetic data related to dietary intake were obtained from the IEU public database, and genetic data related to micronutrients were obtained from previous genome-wide association studies. Summary statistics for microvascular complications of diabetes were obtained from the FinnGen consortium. Random-effects inverse variance weighted estimation was used as the primary method. Heterogeneity was tested using Cochran's Q statistic. The MR-Egger intercept was used to test for pleiotropy. In addition, we used leave-one-out analysis to test for the presence of SNPs that independently influenced the results.
Results
Inverse variance weighted estimates suggest coffee intake leads to increased risk of DR [OR = 2.15, 95%CI(1.44–3.20), p = 1.68E-04] and DN [OR = 3.34, 95%CI(1.72–6.46), p = 3.54E-04]. Cheese intake has a protective effect on DR [OR = 0.50, 95%CI(0.34–0.74), p = 4.39E-04]. No significant correlation was observed between micronutrients and two diabetic microvascular complications.
Conclusions
These findings expose a causal relationship between diet and microvascular complications of diabetes. Coffee intake was associated with an increased risk of DR and DN. Cheese intake was associated with decreased risk of DR.