bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flow Around Tandem Cylinders and Dynamic Meshing
Authors: Singh Prabhjot , Klein Marten 
Published: May 2023

Abstract
The behavior of flow around a single cylinder is complex, and when multiple cylinders are arranged in a tandem or multi-cylinder configuration, the complexity increases significantly. This arrangement is commonly used in aerodynamic applications and dynamic states, presenting challenges in grid and mesh quality, boundary conditions, numerical stability, and mesh adaptivity. This study aims to simulate flow around multiple cylinder arrangements, comparing static and dynamic cases and presenting results through vorticity distributions, wake flow, pressure distributions, drag and lift coefficients, and flow separations. The paper addresses the strategies used for numerical setup, boundary conditions, solvers, or models used using OpenFOAM open-source code, and data validation. In addition, the study simulates the flow around rotating multiple cylinders using dynamic meshes, ensuring good transport of properties between the boundaries of the dynamic mesh while retaining the underlying physics. The results show that the flow around the cylinder is laminar and steady for Reynolds numbers below approximately 40-50, while Von Karman vortices can be observed for Reynolds numbers between approximately 40-200, and horseshoe vortex for Reynolds numbers greater than approximately 200. The Coefficient of pressure also changes accordingly. With dynamic arrangement, the study was able to establish a good master-slave arrangement, depict complex mean flow between the cylinder, and periodic changes in Coefficient of pressure along the rotating cylinder. Result validation was also conducted. This dynamic mesh and simulation for rotating cylinders are still a work in progress, with ongoing efforts to develop a solver for greater accuracy and less computational expense and time-consuming simulations. Future expectations include the concept of vertical axis turbines and other commonly used in aerodynamic applications.
Guiding the Honeybee Navigation System Using the Second-Harmonic Line Width of 456 nm Nd:GdVO4 Laser to Prevent CCD Phenomenon
Authors: Mohammadi Fatemeh , Bozorgmanesh Mohammad Amin 
Published: May 2023

Abstract
Today, one of the biological problems is electromagnetic pollution in the environment. The intensity of electromagnetic radiation is so pervasive that it is now known as a form of latent and silent pollution. The study of the biological effects of these waves on the growth and development of living insects - such as bees - are considered by many scientific communities around the world. However, the response of honey/wild bees to traps designed to selectively stimulate bee light receptors by fluorescent light indicated that selective arousal of the blue light receptor type was highly attractive. In this paper, to selectively stimulate the blue light receiver in bee species in order to guide the bee navigation system to return to its hive and prevent the colony collapse disorder (CCD) phenomenon, high-efficiency continuous laser emission by second-harmonic line width of 456 nm Nd:GdVO4 laser is proposed.
Compost and biogas market in Côte d'Ivoire: Economic impact assessment by CGE model
Authors: Fabrice Ochou Essé , Kamagaté Tidiane , Dagbaud Ulrich , koné Tiangoua 
Published: May 2023

Abstract
The latest National Determined Contributions in Côte d'Ivoire reveal that the waste sector is a significant contributor to greenhouse gas emissions. Despite the potential for composting and biogas to increase waste valorization, these sectors are underdeveloped and lack a legal framework. The aim of this paper is to analyze the economic benefits of a composting and biogas policy implementation in Côte d'Ivoire. Using a Computable General Equilibrium Model (CGE), the study takes into account the impact of these sectors on the economy and the effects of household and agricultural wastes, which are currently excluded from the national nomenclature. The results of the simulation showed positive impacts on green growth, employment, investment and demand, among others.
Outcomes of Intervention Program on Nurses Caring of Patients with Heart Failure
Authors: Elsenousy Tahany Ahmed , Maarouf Dina Mohamed , Mohamed Mahmoud Hassan 
Published: May 2023

Abstract
Heart failure (HF) is a chronic condition that affects a significant number of patients worldwide, requiring specialized management. Nurses have a great role in the care of these patients, and intervention programs are designed to enhance their performance, leading to improved patient outcomes.
Objectives: To investigate the outcomes of the HF intervention program regarding nurses' knowledge, practice, and patient outcomes at the Cardiac Care Unit (CCU).
Method: A quasi-experimental research design was implemented in this study. The study included all 30 cardiac nurses working on the unit. In addition, a convenience sample of 108 conscious adults with HF was divided into two groups of 54 patients each. For collecting data, four different tools were used. Tool I: A Structured Knowledge Questionnaire; Tool II: Heart Failure Management Observational Checklist; Tool III: Patients' Assessment Questionnaire; and Tool IV: Kansas City Cardiomyopathy Questionnaire (KCCQ-12).
The study results showed significant differences in the knowledge and practice categories of nurses following the intervention program compared to their pre-intervention levels. After the intervention program, the nurses displayed good knowledge and satisfactory practice, compared to poor knowledge and unsatisfactory practice before the program (p = 0.00). Furthermore, the study group displayed a significant improvement in their KCCQ-12 total mean score (42.4 ± 16.6) compared to the control group (38.5 ± 17.7) (p = 0.00).
In conclusion, this study provides strong evidence of the HF intervention program's effectiveness in enhancing nurses' knowledge and practice, as well as improving patient outcomes.
Is rhythmic auditory stimulation the most effective therapy for functional ambulation after stroke? A systematic review
Authors: Gonzalez-Hoelling Samira , Reig-García Gloria , Bertran-Noguer Carme , Suñer-Soler Rosa 
Published: May 2023

Abstract
Background
Several studies have reported the effect of rhythmic auditory stimulation (RAS) on functional ambulation in stroke patients, yet a systematic overview is currently lacking. This study aims to summarize and evaluate the available evidence about the efficacy of RAS for functional ambulation, consider the use of walking assistive devices during the assessment or the intervention in stroke patients, and to find out if the effect of RAS and music-based RAS differs depending on the stroke brain site and affected area.
Methods
The Pubmed, PEDro, Cochrane Central Register of Controlled Trials, Web of Science, Scopus and CINAHL electronic databases were searched for reports evaluating the effect of RAS on walking in stroke patients.
Results
Nineteen articles were included (916 stroke survivors). Most studies were of good methodological quality according to the PEDro scale, but they had a high risk of bias. The most consistent finding was that RAS improves walking and balance parameters in stroke patients in all phases compared to baseline and versus control groups with conventional treatment. Functional ambulation and the use of walking assistive devices were inconsistently reported. Several studies also suggest that RAS may are as good as other complementary therapies (horse-riding and visual cueing).
Conclusions
Despite the beneficial effects of RAS, the question remains as to whether it is better than other complementary therapies. Given the heterogeneity of the interventions, the interventions in control groups, the varied durations, and the different outcome measures, we suggest that care should be taken in interpreting and generalizing findings.
PROSPERO registration number
: CRD42021277940
Removal of antibiotics with different charges in water by graphene oxide membranes
Authors: Liang Zimeng , Zhao Xin , Huang Weiqi , Qi Huabiao , Wang Can 
Published: May 2023

Abstract

Antibiotics are a large group of emerging organic pollutants with low concentration levels in the water. The presence of antibiotics will affect the ecological environment and human health. The removal of trace organic compounds by graphene oxide (GO) membranes has attracted extensive attention. This study investigated the removal of three differently charged antibiotics by GO membranes and the influence of water quality on the removal of antibiotics. It showed that a crosslinked ethylenediamine-GO (EDA-GO) membrane had better stability and higher antibiotic removal performance than a non-crosslinked GO membrane. Among the three antibiotics, penicillin (PNC) was negatively charged and had the highest removal efficiency due to steric effect and electrostatic repulsion. A low concentration (10 mmol L−1) of Na+ in water could increase the membrane flux but had no significant effect on the removal of antibiotics. Ca2+ could reduce the membrane flux and improve the removal of chloramphenicol (CAP) and PNC. The removal efficiencies of low-concentration antibiotics (500 μg L−1) were higher than those of high-concentration antibiotics (10 mg L−1). Furthermore, the removal of antibiotics under the condition of actual wastewater quality was higher than those in solutions prepared with ultrapure water. The EDA-GO membrane has great potential in the removal of antibiotics in wastewater.
Therapeutic Potential of Decoys for Prostate Cancers: A Review of
Recent Updates
Authors: Rezaei Samaneh , Mahjoubin-Tehran Maryam , Iratni Rabah , Sahebkar Amirhossein 
Published: May 2023

Abstract:
Prostate cancer is ranked second among the most common male cancers. Androgen
deprivation therapy (ADT) has long been the first-line treatment and the basis for
all other therapies, reducing circulating androgens to castration levels and preventing disease
development. Nevertheless, ADT monotherapy may not always limit disease development,
and even at low testosterone levels, hormone-sensitive prostate cancer will become
castration-resistant. Recent research demonstrates that prostate cancer can have a
range of potentially actionable genetic abnormalities; no medications that target these
variations have yet been shown to elicit therapeutic advantages. Despite their established
efficacy in the management of other cancers, advanced genetic or immunological approaches
are not regularly used to treat prostate cancer patients. As a result, there is an unmet
demand for medicines that offer a better chance of survival than the existing castration-
resistance prostate cancer (CRPC) therapy regimens. The use of oligodeoxynucleotides
(ODN) and peptides in decoy technology have been developed as novel therapeutic
approaches. Decoy ODNs bind to a particular transcription factor with high affinity
and may suppress gene transcription. Peptide decoys bind to specific ligands with high
specificity and inhibit signaling pathways. Recent evidence supports the notion that these
techniques are promising and attractive in the fight against cancer. In the present review,
we discuss the use of decoy technology as a novel therapeutic approach against prostate
cancer.
Multiple Protein Biomarkers and Different Treatment Strategies for
Colorectal Carcinoma: A Comprehensive Prospective
Authors: Chakraborty Biswadip , Agarwal Shivangi , Kori Shivam , Das Ratnesh , Kashaw Varsha , Iyer Arun K. , Kashaw Sushil Kumar 
Published: May 2023

Abstract:
In this review, we emphasized important biomarkers, pathogenesis, and newly
developed therapeutic approaches in the treatment of colorectal cancer (CRC). This includes
a complete description of small-molecule inhibitors, phytopharmaceuticals with antiproliferative
potential, monoclonal antibodies for targeted therapy, vaccinations as immunotherapeutic
agents, and many innovative strategies to intervene in the interaction of
oncogenic proteins. Many factors combine to determine the clinical behavior of colorectal
cancer and it is still difficult to comprehend the molecular causes of a person's vulnerability
to CRC. It is also challenging to identify the causes of the tumor's onset, progression,
and responsiveness or resistance to antitumor treatment. Current recommendations for
targeted medications are being updated by guidelines throughout the world in light of the
growing number of high-quality clinical studies. So, being concerned about the aforementioned
aspects, we have tried to present a summarized pathogenic view, including a brief
description of biomarkers and an update of compounds with their underlying mechanisms
that are currently under various stages of clinical testing. This will help to identify gaps or
shortfalls that can be addressed in upcoming colorectal cancer research.
FOXD3 Suppresses the Proliferation of CRC Bone Metastatic Cells via the
Ras/Raf/MEK/ERK Signaling Pathway
Authors: Wang Kangwei , Chu Yan , Zhang Hongqiang , Qu Xinglong , Wang Bing , Han Yu 
Published: May 2023

Background:
The improvements in the treatment of colorectal cancer (CRC) and prolongation
of survival time have improved the incidence of bone metastasis. Forkhead box D3
(FOXD3) is involved in the development of CRC. However, the role and mechanism of FOXD3 in
CRC bone metastases development are unknown.

Objective:
Using the combined bioinformatics and cytology experimental analyses, this study
aimed to explore the mechanistic role of FOXD3 in the bone metastasis of colon cancer, thereby aiding
in the treatment of colon cancer bone metastasis and identification of drug-targeting markers.

Methods:
First, the changes in the expression levels of the FOXD3 gene and differentially expressed
genes (DEGs) between the colon cancer samples and colon cancer metastases were obtained
from The Cancer Genome Atlas (TCGA) database. Then, the correlations of the FOXD3
gene with the DEGs were identified. Next, the effects of the FOXD3 on the proliferation and invasion
abilities of colon cancer bone metastatic cells were identified using Cell Counting Kit-8
(CCK8) and Transwell cell migration assays, respectively. In addition, Western blot analysis was
used to identify the expression levels of the proteins related to the EGFR/Ras/Raf/MEK/ERK
(EGFR/ERK) signaling pathway and epithelial-to-mesenchymal transition (EMT).

Results:
FOXD3 was downregulated in colon cancer and could interact with multiple DEGs in colon
cancer bone metastases. FOXD3 gene knockdown could increase the proliferation of human
colon cancer bone metastatic cells and their invasive ability. FOXD3 gene knockdown could activate
the expression of EGFR/ERK signaling pathway-related proteins and inhibit/promote the expression
of EMT-related proteins, which in turn promoted the proliferation and metastasis of LoVo
cells from colon cancer bone metastases.

Conclusion:
Overall, this study demonstrated that the downregulation of the FOXD3 gene might
promote the proliferation of colon cancer bone metastatic cell lines through the EGFR/ERK pathway
and promote their migration through EMT, thereby serving as a promising therapeutic target.
Anti-tumoral Titanium(IV) Complexes Stabilized with Phenolato Ligands and Structure-Activity Relationship
Authors: Zhao Tiankun , Wang Peng , Zhang Xupeng , Liu Nan , Zhao Wenzhuo , Zhang Yong , Yuan Pengpeng , Li Shanjia , Yang Mingjun , Yang Zhongduo , Huhn Thomas 
Published: May 2023

Abstract:
Titanocene dichloride and budotitane have opened a new chapter in medicinal chemistry of titanium(IV) complexes being novel non-platinum antitumor metallic agents. Numerous efforts have led to the discovery of the diamino bis-phenolato titanium(IV) complexes. Among which, the [ONNO] and [ONON] type ligands namely Salan, Salen and Salalen coordinated titanium(IV) alkox-yl complexes have demonstrated significantly enhanced aqueous stability, their in vitro and in vivo antitumor efficacy, mechanism of action, structure-activity relationships and combined tumor thera-py have been intensively investigated. Replacement of the labile alkoxyls with a second chelator re-sulted in structural rigid titanium(IV) complexes, which showed exceedingly good aqueous stability and potent antitumor activity both in vitro and in vivo. The unique ligand system successfully al-lowed the access of isotopic [45Ti]Titanium(IV) complexes, post-synthetic modification, facile syn-thetic protocols and antitumor congeneric zirconium(IV) and hafnium(IV) complexes. This review presents recent research progress in the field of antitumor group 4 metal complexes stabilized with phenolato ligands; especially their structure-activity relationships are summarized.
Biomarkers of Growth Faltering and Neurodevelopmental Delay in
Children who are HIV-Exposed but Uninfected: A Systematic Review
Authors: Sirajee Reshma , Brophy Jason , Conroy Andrea L. , Namasopo Sophie , Opoka Robert O. , Rai Urvi , Forgie Sarah , Salami Bukola O. , Hawkes Michael T. 
Published: May 2023

Introduction:
Children who are HIV-exposed but uninfected (CHEU) are at risk of linear
growth faltering and neurodevelopmental delay. Circulating biomarkers associated with these adverse
outcomes may elucidate pathways of injury.

Objective:
To identify biomarkers associated with growth faltering and neurodevelopmental delay
in CHEU.

Methods:
We performed a systematic review of electronic databases MEDLINE (1946-April 2021),
EMBASE (1974-April 2021), Scopus (2004-April 2021), and PubMed (1985-April 2021), following
the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The systematic
review was registered on the International Prospective Register of Systematic Reviews
(PROSPERO, registration number CRD42021238363).

Results:
We found seven studies associating biomarker abnormalities and growth outcomes in
CHEUs and two studies on biomarker abnormalities and neurodevelopmental delay. Biomarker abnormalities
associated with growth restriction were: C-reactive protein (CRP), tumour necrosis factor
(TNF), interferon-gamma (IFN-γ), interleukin (IL)-12p70, IFN-γ-induced protein-10
(CXCL10/IP-10), lipopolysaccharide binding protein (LBP), insulin-like growth factor-1 (IGF-1),
and IGF-binding protein-1 (IGFBP-1). Biomarkers associated with motor, language, and cognitive
delay were CRP, IFN-γ, IL-1β, -2, -4, -6, -10, -12p70, neutrophil gelatinase-associated lipocalin
(NGAL), granulocyte-macrophage colony-stimulating factor (GM-CSF), and matrix metalloproteinase-
9 (MMP-9).

Conclusion:
Elevated markers of inflammation (acute phase reactants, pro-inflammatory cytokines,
chemokines) and intestinal microbial translocation are associated with growth faltering. Elevated
markers of inflammation are associated with adverse neurodevelopment.
Synthesis and Self-assembly of a Novel Amphiphilic Tri-arm Star-shaped Copolymer Poly(ethylene oxide)-b-Poly(ε-caprolactone)
Authors: Zhang Xiaoyan , Kang Kexin , Wu Tao 
Published: May 2023

Abstract:Amphiphilic tri-arm star-shaped copolymers, poly(ethylene oxide)-b-poly(ε-caprolactone) PEO3-b-PCL3, with different poly (ε-caprolactone) (PCL) molecular weights were successfully synthesized by ring-opening polymerization (ROP). Firstly, the tri-arm star-shaped PEO3 was prepared by ROP of trimethylolpropane and ethylene oxide (EO). The ring-opening polymerization (ROP) of ε- caprolactone (CL) was initiated using the tri-arm star-shaped PEO3 with the hydroxyl group as macroinitiator and Sn(Oct)2 as a catalyst. Amphiphilic tri-arm star-shaped copolymers PEO3-b-PCL3 were obtained. By changing the ratio of monomer and macroinitiator, a series of PEO3-b-PCL3 were prepared with a well-defined structure, molecular weight control, and narrow molecular weight distribution. The expected intermediates and final products were confirmed by 1H NMR and Gel Permeation Chromatography (GPC) analyses. In addition, the sizes and morphologies of the obtained micelles with different PCL segment lengths were investigated with dynamic light scattering (DLS) and transmission electron microscopy (TEM), respectively. It was found that the self-assembly morphologies were spherical micelle in aqueous solution.
Analysis of Ultrasound Supported Antimicrobial and Antibiofilm Activities
of Disinfection By-product Bromochloroacetonitrile
Authors: E.R. Sevda 
Published: May 2023

Introduction:
Some microorganism threaten human health by forming biofilm in water systems. Because microorganism in the biofilm structure are more resistant to antimicrobials.

Methods:
Water systems are disinfected with physical methods, such as ultrasonication techniques and chemical disinfectants. Bromochloroacetonitrile is produced as a by-product from algae and fulvic acid sources during water chlorination. This study aimed to investigate the antimicrobial and antibiofilm effects of bromochloroacetonitrile on some bacteria alone and with ultrasound treatment.
The study used Escherichia coli ATCC 25922, Klebsiella pneumoniae MCTC 13438, and Staphylococcus aureus ATCC 25923 strains. The antimicrobial and antibiofilm activities of the test substance were analyzed alone with bromochloroacetonitrile and Ultrasound-assisted. Minimum Inhibitory Concentration values of the test substance against Escherichia coli ATCC 25922, Klebsiella pneumoniae MCTC 13438, and Staphylococcus aureus ATCC 25923 strains were 25, 25 and 50 mM, respectively, and Minimum Bactericidal Concentration values were 50, >50, and >50 mM, respectively.

Results:
The obtained data show that bromochloroacetonitrile is a potential disinfection agent that can be used against biofilm formation in water systems. Besides, it was revealed that when ultrasound treatment was applied with bromochloroacetonitrile, it showed 100% antibiofilm activity on E. coli and K. pneumoniae and 79.45% antibiofilm activity on S. aureus strains. The obtained data show that bromochloroacetonitrile is a potential disinfection agent that can be used against biofilm formation in water systems. This study is preliminary and planned to reveal the cytotoxic effects of bromochloroacetonitrile on healthy human skin and liver cells in the following study.

Conclusion:
These results will contribute to the literature, as no study reveals the antimicrobial and antibiofilm activities of bromochloroacetonitrile.