bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climbing perch Anabas testudineus avoid expanded polystyrene pellets ingestion
Authors: Ganzha Ekaterina , Pavlov Efim , Duc Dien Tran 
Published: December 2022

Abstract

The climbing perch Anabas testudineus is widespread in the inland waters of Vietnam and according to its ecology could have contact with a floating plastic waste. The fragments of expanded polystyrene (EPS) detected into the fresh waters of Vietnam in Khanh Hoa, Lam Dong, Phu Yen provinces. Our study was focused on estimation of probability of ingestion of EPS pellets (size 2.5–3.5 mm) by adult climbing perch. In the experiments three types of treatment pellets were proposed to fish: 24 feed pellets (Fp), 24 expanded polystyrene pellets (Pp), 12 feed & 12 expanded polystyrene pellets (FPp). Fish grasping time of first pellet was independent in all treatment types. The time grasping of 12th pellet was insignificant in Fp (63 s) and Pp (75 s). Climbing perch was grasping and ingesting of 24th Fp significantly (p = 0.02) earlier (143 s), than grasping of 24th Pp (817 s). Fish with FPp treatment was grasping feed along with EPS pellets, but grasping of 12th Fp was significantly (p = 0.02) earlier (49 s), then 12th Pp (193 s). By the end of tests fish ingested all feed pellets. We discovered that climbing perch grasped Pp and kept them in oral cavity, but always rejected them in 100% cases. This result evidenced that climbing perch has effective defense mechanism avoiding ingestion of expanded polystyrene pellets with size 2.5–3.5 mm, which realized by taste system and tactile reception of fish.
Overexpression of a WRKY transcription factor McWRKY57-like from Mentha canadensis L. enhances drought tolerance in transgenic Arabidopsis
Authors: Bai Yang , Zhang Ting , Zheng Xiaowei , Li Bingxuan , Qi Xiwu , Yu Xu , Li Li , Liang Chengyuan 
Published: December 2022

Abstract
Background: Drought has become a major environmental problem affecting crop production. Members of the WRKY family play important roles in plant development and stress responses. However, their roles in mint have been barely explored.
Results: In this study, we isolated a drought-inducible gene McWRKY57-likefrom mint and investigated its function. The gene encodes a group IIc WRKY transcription factor, McWRKY57-like, which is a nuclear protein with a highly conserved WRKY domain and a C2H2 zinc-finger structure, and has transcription factor activity. Its expression levels were examined in different tissues of mint and under the treatment of mannitol, NaCl, abscisic acid, and methyl jasmonate. We found that McWRKY57-likeoverexpression in Arabidopsis significantly increased drought tolerance. Further studies showed that under drought stress, McWRKY57-like-overexpressing plants had higher chlorophyll, soluble sugar, soluble protein, and proline contents but lower water loss rate and malondialdehyde content than wild-type plants. Moreover, the activities of antioxidant enzymes catalase, superoxide dismutase, and peroxidase were enhanced in McWRKY57-like transgenic plants. Furthermore, qRT-PCR analysis revealed that the drought-related genes AtRD29A, AtRD29B, AtRD20, AtRAB18, AtCOR15A, AtCOR15B, AtKIN2, and AtDREB1A were upregulated in McWRKY57-liketransgenic plants than in wild-type Arabidopsis under drought conditions.
Conclusion: These data demonstrated that McWRKY57-like conferred drought tolerance in transgenic Arabidopsis by regulating plant growth, osmolyte accumulation and antioxidant enzyme activities, and the expression of stress-related genes. The study indicates that McWRKY57-like plays a positive role in drought response in plants.
Monocular 3D Human Pose-Estimation Networks for Coherent Humanoid-Model Driving
Authors: Yang Wei-Jong , Chan Din-Yuen , Liou Jhih-Siang 
Published: December 2022

Abstract
In this paper, we propose a vivid 3D pose driving (3PD) system containing 2D skeleton pose estimation (2D SPE) network, 3D association pose estimation (3D APE) network and 3D angle-matching (3D-AM) engine. The 2D SPE network consecutively predicts the joint coordinates of human 2D pose per frame for a video string. Then, the 3D APE network associates the successive 2D poses to predict the 3D skeletons of dynamic poses, which can be a causal or non-causal temporal convolutional network. The experimental results demonstrate that the integration of the 2D SPE network and the non-causal 3D APE network can generate accurate dynamic 3D skeletons. Then, the 3D-AM engine can apply those dynamic 3D skeletons to stably drive an on-line 3D avatar. By our 3PD system, the driven avatar can coherently follow user’s dynamic motions with natural agile activities for VR applications. The experimental results can demonstrate that the integration of 2D SPE and 3D APE networks can in usual attain the accurate 3D human-pose estimation without anyone auxiliary training appropriated to occluded joints. Besides, relative to the compared state-of-art networks, our integrated convolutional neural network (CNN) can have structural regularity and computational lightweight.
Neuroprotective effects of ivermectin against transient cerebral ischemia-reperfusion in rats
Authors: Seyyedabadi Behdad , Babataheri Shabnam , Laher Ismail , Soraya Hamid 
Published: December 2022

Abstract
Stroke is a leading cause of disability and death worldwide. Ivermectin is a broad-spectrum anti-parasitic agent with potential anti-bacterial, anti-viral, and anti-cancer effects. However, the effects of ivermectin on the brain are poorly described. This study examined the effects of ivermectin on cerebral ischemia-reperfusion (IR) in rats. A rat model of transient global IR was induced by bilateral carotid artery occlusion for 20 min. Rats received ivermectin (2 mg/kg/day, ip) one hour after inducing cerebral IR for three consecutive days at 24-h intervals. Next, we examined the effects of ivermectin on brain infarction, histopathology, malondialdehyde levels, myeloperoxidase activity, spatial learning and memory, and phospho-AMPK protein levels. The results showed that ivermectin reduced brain infarct size (P < 0.001) and histopathological changes such as cerebral leukocyte accumulation and edema (P < 0.05) compared to untreated rats with IR. Treatment with ivermectin also decreased myeloperoxidase activity (P < 0.01) and malondialdehyde levels (P < 0.05) while increasing AMPK activity (P < 0.001), memory, and learning compared to the untreated IR group. Overall, we show for the first time that ivermectin conferred neuroprotective effects in a rat model of cerebral IR. Our results indicate that ivermectin reduced brain infarct size, lipid peroxidation, and myeloperoxidase activity and improved memory and learning in rats with cerebral IR. These effects likely occurred via AMPK-dependent mechanisms.
Effect of a Remote Peer-administered Behavioral Activation and Peer-support intervention for Antenatal Depression on Gestational Age at Delivery: a single-blind, randomized control trial
Authors: Chaput Kathleen , Freeman Makayla , McMorris Carly , Metcalfe Amy , Cameron Emily E , Jung James , Tough Suzanne , Hicks Laurel M. , Dimidjian Sona , Tomfohr-Madsen Lianne 
Published: December 2022

Abstract
Background: Antenatal depression (AD) is the most common complication of pregnancy in developed countries and increases risk of preterm birth (PTB). Many pregnant individuals with AD do not obtain treatment due in part to risks associated with antidepressant medications, the expense and wait times for psychological services, and perceived stigma. Accessible and timely treatment of antenatal depression is crucial to minimize foetal impacts and associated long-term child health outcomes. Previous studies show that behavioural activation and peer-support are promising avenues of treatment for perinatal depression. Additionally, remote and paraprofessional counselling interventions show promise as more accessible, sustainable, and cost-effective treatment avenues than traditional psychological services. The primary aim of this trial is to test the effectiveness of a remote, behavioural activation and peer support intervention, administered by trained peer para-professionals, for increasing gestational age at delivery among those with antenatal depression. The secondary aims are to evaluate the effectiveness for treating AD prior to delivery, with persistence into the postpartum; improving anxiety symptoms; and improving parenting self-efficacy compared to controls.
Methods: A two-arm, single-blinded, parallel groups randomized controlled trial (RCT) with repeated measures will be conducted. Participants scoring >10 on the Edinburgh Postnatal Depression Scale will be recruited from the larger P3 cohort and invited to enroll. Assessments will be conducted prior to 27 weeks’ gestation at trial intake (T1), post-intervention, prior to delivery (T2), 5-6 months postpartum (T3), and 11-12 months postpartum (T4) and will include self-report questionnaires and linked medical records.
Discussion: Our remote, peer paraprofessional-delivered behavioural activation plus peer support intervention has the potential to successfully reduce symptoms of AD, which may in turn decrease the risk of PTB and subsequent health impacts. The current trial builds on previous findings and uses a patient-oriented approach to address priorities for patient care and to provide a cost-effective, accessible, and evidence-based treatment to pregnant individuals with AD.
Trial registration: ISRCTN51098220
Human Glioma Endothelial Cells With Stem cell properties
Authors: Sharma Aman , Muzumdar Dattatraya , Shiras Anjali 
Published: December 2022

Abstract
Glioblastoma (GBM) tumor relapse is attributed to presence of therapy defying Glioma stem cells (GSCs). GSCs have been shown to trans-differentiate into endothelial-like cells. However, the influence of tumor micro-environment on endothelial cells is not clearly understood. Here, we investigated whether tumor micro-environment conditioning can alter endothelial cell phenotype and endow them with stem cell-like properties. For this, we establishing a battery of primary human glioma endothelial cell cultures (hGECs) and characterized them for purity in multiple in vitro, in vivo assays. Our data shows that hGECs harbored stemness and multi-lineage differentiation potential as assessed in serum free growth assay, sphere forming assay, limiting dilution assay, and in a serum-induced differentiation assay where Nestin and CD31 co-expressing hGECs could spontaneously differentiation into GFAP positive cells. Moreover, immunohistochemistry analysis of human GBM tumors showed that tumor vessel regions expressed two key stem cell specific markers Nestin and Mushashi. Together, our data shows that tumor-specific endothelial cells are enriched with stem cell properties in GBM.
The level of Knowledge, Attitudes, and Practices concerning Covid-19 Vaccination and their Determinants in Chittagong District (Bangladesh)
Authors: Akter Sahin , Bajinka Ousman , faria Faiza shareen , Ashrafuzzaman Mohammad , Liu Aizhong 
Published: December 2022

Abstract
Background: Bangladesh has not previously experienced epidemics such as SARS or MERS, and it is clear that its public healthcare systems are not readily prepared for COVID-19 vaccine uptake.
Objective: The aim of this research was to evaluate the level of knowledge, attitudes, and practices concerning COVID-19 vaccination and their determinants in Chittagong District, Bangladesh.
Methods: This descriptive cross-sectional study was conducted in Chittagong, Bangladesh, from October 2021 to April 2022. A study of 2,882 men and women who had been vaccinated with the COVID-19 vaccine and those who had not been vaccinated was conducted in Chittagong, Bangladesh. A purposeful sampling method was used in this study. The data was collected using a standardized pretested questionnaire.
Results: A total of 850 men and women’s information was obtained, of which Group A = 205 (24.12%) for men and women who had been vaccinated, and Group B = 645 (75.88%) for men and women who had not been vaccinated. There were group/independent variables that entered the equation for subgroup analysis. Sensitivity analysis showed that the majority of the men and women that had been vaccinated had a good level of knowledge, attitudes, and practices regarding COVID-19 vaccination with (OR=0.166, 95% CI: 0. 113~0.245) and (OR=0.191, 95% CI: 0. 113~0.245), respectively. In addition, most of the men and women that were unvaccinated had poor/bad level of knowledge, attitudes, and practices regarding COVID-19 vaccination with (OR=0.228, 95% CI: 0.154~0.336) and (OR=0.239, 95% CI: 0.154~0.336), respectively. Most of the participants were aged between 40-49 years. The majority of the participants were Muslims, had secondary school level of education, and were employed.
Conclusion: The results suggest that the epidemic has significantly increased the level of knowledge, attitudes, and practices concerning COVID-19 vaccination. In addition, the factors affecting the level of knowledge, attitudes, and practices concerning COVID-19 vaccination are different. This means that relevant pro-vaccination promotion strategies are needed to ensure the safety of the people during the epidemic. Under the normalization of the epidemic situation, the local area should optimize public health education, allocate medical resources rationally, and avoid ignoring the routine COVID-19 vaccination for effective and efficient prevention and control of the rapid spread of the COVID-19 epidemic.
Long-Term Outcomes of TEVAR for Thoracic Aortic Diseases: A Retrospective Single-Center Study
Authors: Deniz Gökay , Ozcınar Evren , Kasimzade Ferit , Yazicioglu Levent , Eryilmaz Sadik 
Published: December 2022

Abstract
Background: Long-term outcomes of TEVAR for different aortic pathologies are still debated for years. The procedural success and outcomes differ by comorbidities and thoracic aortic pathologies. Therefore, we present our ten-year experience, encountered rare complications, and long-term results.
Methods: Between 2006 to 2018, 97 patients underwent endovascular treatment for several indications. The primary endpoints are to explore the leading mortality causes, complications, and reinterventions, evaluate the effects of comorbidities on survival, and compare several indications with survival curves. The second is to investigate rare complications and graft durability in long-term follow-ups.
Results: The most indication was thoracic aortic aneurysm (n=52). Ten patients had aortic arch variations and anomalies, and the bovine arch was observed in 8 patients. Endoleaks were the main encountered complication, and 10 of 15 endoleaks were type 1 endoleak. Total reinvention was 18, and the most intervention was reTEVAR (n=5). Overall mortality was 20, and TEVAR-related death mortality was 12. Multivariant Cox regression revealed chronic renal diseases (OR=11.73; 95% CI:2.04-67.2; p=0.006), previous cardiac operation (OR:14.26; 95% CI: 1.59-127.36; p=0.01), chronic obstructive pulmonary diseases (OR:7.82; 95% CI: 1.43-42.78; p=0.001) to be an independent risk factor for 10-year-survival. There was no significant difference in the Kaplan-Maier survival curves of different aortic pathologies.
Conclusion: In long-term follow-ups, comorbid factors could independently be risk factors for mortality; however, there is no significant difference in endoleaks occurrence. TEVAR is a suitable solution for severe aortic pathologies with similar outcomes. Graft thrombosis in years should be a question on graft durability.
Opioid-free anesthesia with lidocaine for better postoperative recovery in hysteroscopy
Authors: Cha Ning-hui , Hu Yang , Zhu Guo-hong , Long Xiang , Jiang Jing-jing , Gong Yuan 
Published: December 2022

Abstract
BACKGROUND: Anesthesia with opioids negatively affects patients’ quality of recovery, and opioid-free anesthesia attempts to avoid these effects. This study aimed to evaluate the effect of opioid-free anesthesia on the quality of recovery, using lidocaine on patients undergoing hysteroscopy.
METHODS: A parallel-group, randomized, double-blind, controlled trial was conducted in Yichang Central Peoples’ Hospital, Hubei Province, China, from January to April, 2022. We included 90 female patients (age: 18–65 years, American Society of Anesthesiologists Physical Status Class I–II) scheduled for elective hysteroscopy, 45 of whom received lidocaine (Group L), and 45 received sufentanil (Group S). Patients were randomly allocated to receive either lidocaine or sufentanil perioperatively. The primary outcome was the quality of postoperative recovery, which was assessed using the QoR-40 questionnaire.
RESULTS: The two groups were similar in age, American Society of Anesthesiology physical status, height, weight, body mass index, and surgical duration. The QoR scores were significantly higher in Group L than in Group S. The incidence of postoperative nausea and vomiting, as well as the time to extubation were significantly lower in Group L than in Group S.
CONCLUSION: Opioid-free anesthesia with lidocaine achieves a better quality of recovery, faster recovery, and a shorter time to extubation than general anesthesia with sufentanil.
TRIAL REGISTRATION: The trial was registered on January 15, 2022 in the Chinese Clinical Trial Registry (http://www.chictr.org.cn/showprojen.aspx?proj=149386), registration number ChiCTR2200055623.(15/01/2022)
Arithmetic skills are associated with grey matter volume in the left inferior frontal gyrus:
A brain-wide association study with 536 children and adolescents
Authors: Viesel-Nordmeyer Nurit , Prado Jerome 
Published: December 2022

Abstract
Although mental arithmetic is a foundation for mathematical development, it is also the source of large individual differences across development. Although a number of brain-wide association studies have attempted to identify the neural correlates of these individual differences, these studies were largely underpowered and have yielded inconsistent results. In the current voxel-based morphometry study, we merged six structural imaging datasets of children and adolescents (from 7.5 to 15 years) whose arithmetic skills levels were assessed, leading to a combined sample of n=536. Across the whole sample, we found a unique positive relation between arithmetic skills and grey matter volume (GMV) in the left inferior frontal gyrus. We also found positive relations between GMV and arithmetic skills in the bilateral temporal cortex in adolescents. In sum, our results highlight brain-wide associations between arithmetic skills and GMV of perisylvian regions, suggesting a role for language processing in individual differences in arithmetic skills.
A double-threshold score of serum pepsinogen combined with serum albumin improves the screening ability of peptic ulcer
Authors: Wang Binli , Zhang Zheyu , Jin Weili , Chen Haojun , Wang Linfeng , Xu Min , Hou Chaoqun , Zhiquan Qian , Qiu Ziyue , Zhang Sheng 
Published: December 2022

Abstract
Background and purpose: Quickly screening of high-risk of peptic ulcer (PU) is of great significance to avoid gastrointestinal bleeding after antiplatelet therapy. In this study, we hoped to find a fast and less invasive method for PU screening.
Methods: The clinical data of health examined population who were admitted for taking gastroscopic assessment in our hospital, from January 2019 to June 2020, was prospectively collected. PU was defined as a gastric or duodenal mucosal defect >5mm in diameter on gastroscopic assessment.
Results: A total of 902 blood samples were enrolled into analysis. Blood indices showed that PGI and albumin (ALB) were both independently associated with PU (all P<0.05). Based on this, we proposed a PGI and ALB Composite Score (PACS), ranged from 0-2. The ROC analysis showed that PACS had a good diagnostic ability for PU (AUC=0.774, P<0.001). The probability of PU was significantly elevated with the increase of PACS score (PACS 0 vs 1 vs 2=7.9% vs 28.6% vs 62.2%, P<0.001).
Conclusion: Both serum PGI and ALB were associated with the increased rate of PU in health examined population, and the PACS score based on these two items may be used to identify the population with high risk of PU.
Prevalence and Associated Factors of COPD among Hypertensive Patients aged 40 Years or Older in China, 2014 -15
Authors: Zhao Yanfang , Fang Liwen , Wang Zhuoqun , Fan Jing , Cong Shu , Wu Jing 
Published: December 2022

Abstract
Background
COPD and hypertension not only share some risk factors, but also interact in terms of disease progression and death. There are about 300 million hypertensive patients in China, but there is a scarcity of evidence on the prevalence and associated factors of COPD in hypertension population. This study aimed to analyze the prevalence and associated factors of COPD among hypertensive patients in China.
Methods
Data were collected as part of a large-scale and nationally representative sample survey conducted in 125 counties (districts) in 31 provinces (autonomous regions and municipalities) of mainland China aged 40 or above, 2014 -15, which consisted of 24,664 hypertensive patients. The prevalence and associated factors of COPD were analyzed among hypertensive patients population using the Chi-square test and multivariate logistic regression model.
Results
The prevalence of COPD among hypertensive patients aged ≥ 40 years was 15.6% (95% confidence interval [95% CI],0.15–0.16), with a prevalence of 21.9% (95% CI,0.21–0.23) for men and 9.0% (95% CI,0.08–0.10) for women. Among the hypertensive patients, the prevalence of COPD was significantly higher in those who were male (odds ratio [OR], 2.05; 95% CI, 1.82–2.31), aged 70 years or older (OR, 6.00; 95% CI, 5.09–7.01), underweight (OR, 1.54; 95% CI, 1.18–2.05), current smoker(OR, 1.72; 95% CI, 1.53–1.93), with hospital admission due to severe pulmonary diseases in childhood (OR, 1.82; 95% CI, 1.41–2.36), history of tuberculosis (OR, 1.39; 95% CI, 1.08–1.79), with family history of lung diseases (OR, 1.64; 95% CI, 1.50–1.80), with indoor exposure to biomass for cooking or heating (OR, 1.10; 95% CI, 1.01–1.21), and with exposure to dust /chemicals in the workplace (OR, 1.20; 95% CI, 1.10–1.30), compared with their counterparts.
Conclusions
The prevalence of COPD is high in hypertensive patients aged 40 or above in China, which is associated with male gender, older age, less education, low weight, smokers, disease or family history of lung-related diseases, and exposure to dust /chemicals or biofuels. It would be of value to carry out health education, screening and comorbidity co-management for COPD relying on the hypertension community-based health management service among hypertensive patients aged 40 or above.
How are radiologists' decisions impacted by AI suggestions? Moderating effect of explainability inputs and attitudinal priming in examining mammograms
Authors: Mehrizi Mohammad H. Rezazade , Mol Ferdinand , Peter Marcel , Ranschaert Erik , Santos Daniel Pinto Dos , Shahidi Ramin , Fatehi Mansoor , Dratsch Thomas 
Published: December 2022

Abstract
Various studies have shown that medical professionals are prone to follow the incorrect suggestions offered by algorithms, especially when they have limited informational inputs to interrogate and interpret such suggestions and when they have an attitude of relying on them. We examine the effect of correct and incorrect algorithmic suggestions on the diagnosis performance of radiologists when 1) they have no, partial, and extensive informational inputs for explaining the suggestions (study 1) and 2) they are primed to hold a positive, negative, ambivalent, or neutral attitude towards AI (study 2). Our analysis of 2760 decisions made by 92 radiologists conducting 15 mammography examinations show that radiologists' diagnoses follow both incorrect and correct suggestions, despite variations in the explainability inputs and attitudinal priming interventions. We identify and explain various pathways through which radiologists navigate through the decision process and arrive at correct or incorrect decisions. Overall, the findings of both studies show the limited effect of using explainability inputs and attitudinal priming for overcoming the unintended influence of (incorrect) algorithmic suggestions.