bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis
Authors: Matsushita Yuki , Liu Jialin , Chu Angel Ka Yan , Tsutsumi-Arai Chiaki , Nagata Mizuki , Arai Yuki , Ono Wanida , Yamamoto Kouhei , Saunders Thomas L. , Welch Joshua D. , Ono Noriaki 
Published: April 2023

AbstractThe bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. It is well-described that leptin receptor (LepR)+ perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. However, the identity of SSCs in young bone marrow and how they coordinate active bone formation remains unclear. Here we show that bone marrow endosteal SSCs are defined by fibroblast growth factor receptor 3 (Fgfr3) and osteoblast-chondrocyte transitional (OCT) identities with some characteristics of bone osteoblasts and chondrocytes. These Fgfr3-creER-marked endosteal stromal cells contribute to a stem cell fraction in young stages, which is later replaced by Lepr-cre-marked stromal cells in adult stages. Further, Fgfr3+ endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. Therefore, Fgfr3+ endosteal SSCs are abundant in young bone marrow and provide a robust source of osteoblasts, contributing to both normal and aberrant osteogenesis.
Phonon transition across an isotopic interface
Authors: Li Ning , Shi Ruochen , Li Yifei , Qi Ruishi , Liu Fachen , Zhang Xiaowen , Liu Zhetong , Li Yuehui , Guo Xiangdong , Liu Kaihui , Jiang Ying , Li Xin-Zheng , Chen Ji , Liu Lei , Wang En-Ge , Gao Peng 
Published: April 2023

AbstractIsotopic mixtures result in distinct properties of materials such as thermal conductivity and nuclear process. However, the knowledge of isotopic interface remains largely unexplored mainly due to the challenges in atomic-scale isotopic identification. Here, using electron energy-loss spectroscopy in a scanning transmission electron microscope, we reveal momentum-transfer-dependent phonon behavior at the h−10BN/h-11BN isotope heterostructure with sub-unit-cell resolution. We find the phonons’ energy changes gradually across the interface, featuring a wide transition regime. Phonons near the Brillouin zone center have a transition regime of ~3.34 nm, whereas phonons at the Brillouin zone boundary have a transition regime of ~1.66 nm. We propose that the isotope-induced charge effect at the interface accounts for the distinct delocalization behavior. Moreover, the variation of phonon energy between atom layers near the interface depends on both of momentum transfer and mass change. This study provides new insights into the isotopic effects in natural materials.
Teasing out missing reactions in genome-scale metabolic networks through hypergraph learning
Authors: Chen Can , Liao Chen , Liu Yang-Yu 
Published: April 2023

AbstractGEnome-scale Metabolic models (GEMs) are powerful tools to predict cellular metabolism and physiological states in living organisms. However, due to our imperfect knowledge of metabolic processes, even highly curated GEMs have knowledge gaps (e.g., missing reactions). Existing gap-filling methods typically require phenotypic data as input to tease out missing reactions. We still lack a computational method for rapid and accurate gap-filling of metabolic networks before experimental data is available. Here we present a deep learning-based method — CHEbyshev Spectral HyperlInk pREdictor (CHESHIRE) — to predict missing reactions in GEMs purely from metabolic network topology. We demonstrate that CHESHIRE outperforms other topology-based methods in predicting artificially removed reactions over 926 high- and intermediate-quality GEMs. Furthermore, CHESHIRE is able to improve the phenotypic predictions of 49 draft GEMs for fermentation products and amino acids secretions. Both types of validation suggest that CHESHIRE is a powerful tool for GEM curation to reveal unknown links between reactions and observed metabolic phenotypes.
Regulation of molecular transport in polymer membranes with voltage-controlled pore size at the angstrom scale
Authors: Zhu Yuzhang , Gui Liangliang , Wang Ruoyu , Wang Yunfeng , Fang Wangxi , Elimelech Menachem , Lin Shihong , Jin Jian 
Published: April 2023

AbstractPolymer membranes have been used extensively for Angstrom-scale separation of solutes and molecules. However, the pore size of most polymer membranes has been considered an intrinsic membrane property that cannot be adjusted in operation by applied stimuli. In this work, we show that the pore size of an electrically conductive polyamide membrane can be modulated by an applied voltage in the presence of electrolyte via a mechanism called electrically induced osmotic swelling. Under applied voltage, the highly charged polyamide layer concentrates counter ions in the polymer network via Donnan equilibrium and creates a sizeable osmotic pressure to enlarge the free volume and the effective pore size. The relation between membrane potential and pore size can be quantitatively described using the extended Flory-Rehner theory with Donnan equilibrium. The ability to regulate pore size via applied voltage enables operando modulation of precise molecular separation in-situ. This study demonstrates the amazing capability of electro-regulation of membrane pore size at the Angstrom scale and unveils an important but previously overlooked mechanism of membrane-water-solute interactions.
Magnetic wallpaper Dirac fermions and topological magnetic Dirac insulators
Authors: Hwang Yoonseok , Qian Yuting , Kang Junha , Lee Jehyun , Ryu Dongchoon , Choi Hong Chul , Yang Bohm-Jung 
Published: April 2023

AbstractTopological crystalline insulators (TCIs) can host anomalous surface states which inherits the characteristics of crystalline symmetry that protects the bulk topology. Especially, the diversity of magnetic crystalline symmetries indicates the potential for novel magnetic TCIs with distinct surface characteristics. Here, we propose a topological magnetic Dirac insulator (TMDI), whose two-dimensional surface hosts fourfold-degenerate Dirac fermions protected by either the $${p}_{c}^{{\prime} }4mm$$

p

c

′

4
m
m

or $$p{4}^{{\prime} }{g}^{{\prime} }m$$

p

4

′

g

′

m

magnetic wallpaper group. The bulk topology of TMDIs is protected by diagonal mirror symmetries, which give chiral dispersion of surface Dirac fermions and mirror-protected hinge modes. We propose candidate materials for TMDIs including Nd4Te8Cl4O20 and DyB4 based on first-principles calculations, and construct a general scheme for searching TMDIs using the space group of paramagnetic parent states. Our theoretical discovery of TMDIs will facilitate future research on magnetic TCIs and illustrate a distinct way to achieve anomalous surface states in magnetic crystals.
The role of the big geographic sort in online news circulation among U.S. Reddit users
Authors: Bozarth Lia , Quercia Daniele , Capra Licia , Šćepanović Sanja 
Published: April 2023

AbstractPast research has attributed the circulation of online news to two main factors—individual characteristics (e.g., a person’s information literacy) and social media effects (e.g., algorithm-mediated information diffusion)—and has overlooked a third one: the critical mass created by the offline self-segregation of Americans into like-minded geographical regions such as states (a phenomenon called ‘The Big Sort’). We hypothesized that this latter factor matters for the online spreading of news not least because online interactions, despite having the potential of being global, end up being localized: interaction probability is known to rapidly decay with distance. Upon analysis of more than 8M Reddit comments containing news links spanning four years, from January 2016 to December 2019, we found that Reddit did not work as an ‘hype machine’ for news (as opposed to what previous work reported for other platforms, circulation was not mainly caused by platform-facilitated network effects). Rather, news circulation in Reddit worked as a supply-and-demand system: news items scaled linearly with the number of users in each state (with a scaling exponent $$\beta$$
β
$$\approx 1$$

≈
1

, and a goodness of fit $$R^2\approx 0.95$$

R
2

≈
0.95

). Furthermore, deviations from such a universal pattern were best explained by state-level personality and cultural factors ($$R^2\approx \{0.12, 0.39\}$$

R
2

≈

{
0.12
,
0.39
}

), rather than socioeconomic conditions ($$R^2\approx \{0.15, 0.29\}$$

R
2

≈

{
0.15
,
0.29
}

) or political characteristics ($$R^2\approx \{0.06, 0.21\}$$

R
2

≈

{
0.06
,
0.21
}

). Higher-than-expected circulation of any type of news was found in states characterised by residents who tend to be less diligent in terms of their personality (low in conscientiousness) and by loose cultures understating the importance of adherence to norms (low in cultural tightness). Interestingly, the combination of those factors with low levels of education was then associated with the circulation of a particular type of news, that is, misinformation. These results suggest that online interactions are geographically bounded and, as such, news circulation cannot be studied purely as an Internet phenomenon but should be grounded into a user’s offline cultural environment, which has become increasingly segregated over the decades, and is admittedly hard to change.
Existence of La-site antisite defects in $$\hbox{LaMO}_3$$ ($$\hbox{M} = \hbox{Mn}$$, Fe, and Co) predicted with many-body diffusion quantum Monte Carlo
Authors: Ichibha Tom , Saritas Kayahan , Krogel Jaron T. , Luo Ye , Kent Paul R. C. , Reboredo Fernando A. 
Published: April 2023

AbstractThe properties of $$\hbox{LaMO}_3$$

LaMO
3

(M: 3d transition metal) perovskite crystals are significantly dependent on point defects, whether introduced accidentally or intentionally. The most studied defects in La-based perovskites are the oxygen vacancies and doping impurities on the La and M sites. Here, we identify that intrinsic antisite defects, the replacement of La by the transition metal, M, can be formed under M-rich and O-poor growth conditions, based on results of an accurate many-body ab initio approach. Our fixed-node diffusion Monte Carlo (FNDMC) calculations of $$\hbox{LaMO}_3$$

LaMO
3

($$\hbox{M} = \hbox{Mn}$$

M
=
Mn

, Fe, and Co) find that such antisite defects can have low formation energies and are magnetized. Complementary density functional theory (DFT)-based calculations show that Mn antisite defects in $$\hbox{LaMnO}_3$$

LaMnO
3

may cause the p-type electronic conductivity. These features could affect spintronics, redox catalysis, and other broad applications. Our bulk validation studies establish that FNDMC reproduces the antiferromagnetic state of $$\hbox{LaMnO}_3$$

LaMnO
3

, whereas DFT with PBE (Perdew–Burke–Ernzerhof), SCAN (strongly constrained and appropriately normed), and the LDA+U (local density approximation with Coulomb U) functionals all favor ferromagnetic states, at variance with experiment.
Relationship between depression and quality of life among students: a systematic review and meta-analysis
Authors: Fernandes Michele da Silva Valadão , Mendonça Carolina Rodrigues , da Silva Thays Martins Vital , Noll Priscilla Rayanne e Silva , de Abreu Luiz Carlos , Noll Matias 
Published: April 2023

AbstractThe objectives of this systematic review were to estimate the prevalence of depression and to identify the relationship between depression and quality of life (QOL) among high school and university students. Literature search was performed in the Scopus, Embase, PubMed, Scielo, CINAHL and Web of Science databases, following the PRISMA methodology. The results were presented through descriptive approaches and meta-analysis. Thirty-six studies met the eligibility criteria, and twenty-six were included in the meta-analysis. The prevalence of depressive symptoms was 27% (95% CI 0.21–0.33) among students, being high school and university students was 25% (95% CI 0.14–0.37) and 27% (95% CI 0.20–0.34), respectively, and most studies have shown that depression was associated with low QOL. Among the limitations of the study is the difficulty of generalizing the results found, considering the large sample of health students. New studies should be conducted considering the severity, duration, and patterns of depressive symptoms in high school and university students, to better understand the relationship between depression and QOL.
Mutation analysis of pathogenic non-synonymous single nucleotide polymorphisms (nsSNPs) in WFS1 gene through computational approaches
Authors: Zhao Jing , Zhang Siqi , Jiang Yuan , Liu Yan , Zhu Qingwen 
Published: April 2023

AbstractA single base changes causing a change to the amino acid sequence of the encoded protein, which is defined as non-synonymous single nucleotide polymorphisms (nsSNPs). Many of the nsSNPs can cause disease, and these nsSNPs are considered as pathogenic mutations. In the study, the high-risk nsSNPs of WFS1 and their influence on the structure and function of wolframin protein were predicted by multiple bioinformatics software. We obtained 13 high-risk nsSNPs of WFS1. All the 13 high-risk nsSNPs are highly conserved residues with a conservative score of 9 or 8 and mostly may cause a decrease in protein stability. The high-risk nsSNPs have an important effect on not only amino acid size, charge and hydrophobicity, but also protein's spatial structure. Among these, 11 nsSNPs had been previously published or cited and 2 nsSNPs (G695S and E776K) had not been reported to date. The two novel variants increased or decreased hydrogen bonds. In conclusion, through different computational tools, it is presumed that the mechanism of pathogenic WFS1 nsSNPs should include the changes of physicochemical properties, significant structural changes and abnormal binding with functional partners. We accomplished the computational-based screening and analysis for deleterious nsSNPs in WFS1, which had important reference value and could contribute to further studies of the mechanism of WFS1 related disease. The computational analysis has many advantages, but the results should be identified by further experimental studies in vivo and in vitro.
Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models
Authors: Cheung Stanley K. K. , Kwok Jacinda , Or Penelope M. Y. , Wong Chi Wai , Feng Bo , Choy Kwong Wai , Chang Raymond C. C. , Burbach J. Peter H. , Cheng Alfred S. L. , Chan Andrew M. 
Published: April 2023

AbstractPTEN hamartoma tumour syndrome is characterised by mutations in the human PTEN gene. We performed transcriptomic and proteomic analyses of neural tissues and primary cultures from heterozygous and homozygous Pten-knockout mice. The somatosensory cortex of heterozygous Pten-knockout mice was enriched in immune response and oligodendrocyte development Gene Ontology (GO) terms. Parallel proteomic analysis revealed differentially expressed proteins (DEPs) related to dendritic spine development, keratinisation and hamartoma signatures. However, primary astrocytes (ASTs) from heterozygous Pten-knockout mice were enriched in the extracellular matrix GO term, while primary cortical neurons (PCNs) were enriched in immediate-early genes. In ASTs from homozygous Pten-knockout mice, cilium-related activity was enriched, while PCNs exhibited downregulation of forebrain neuron generation and differentiation, implying an altered excitatory/inhibitory balance. By integrating DEPs with pre-filtered differentially expressed genes, we identified the enrichment of traits of intelligence, cognitive function and schizophrenia, while DEPs in ASTs were significantly associated with intelligence and depression.
Effect of the emotional valence of autobiographical memory and parental bonding on depressive symptoms in a community sample
Authors: Fernández-Pérez Dolores , Ros Laura , Jimeno María V. , Latorre José Miguel 
Published: April 2023

AbstractRetrospective perceptions of parental bonding may be a protective factor for emotional health. These perceptions are grounded in autobiographical memory, which plays a key role in the onset and maintenance of depressive symptomatology. The aim of the present study was to explore whether the emotional valence of autobiographical memories (positive and negative) and the dimensions of parental bonding (care and protection) have an impact on depressive symptomatology, examining the role of depressive rumination and possible age-related differences. A total of 139 young adults (18–28 years) and 124 older adults (65–88 years) completed the Parental Bonding Instrument, the Beck Depression Inventory (BDI-II), the Autobiographical Memory Test and the Short Depressive Rumination Scale. Our results show that positive autobiographical memories serve as a protective factor for depressive symptoms in both young and older adults. Additionally, in young adults, high paternal care and protection scores are associated with increased negative autobiographical memories, although this association has no effect on depressive symptomatology. In older adults, high maternal protection scores are directly related to greater depressive symptomatology. Depressive rumination significantly increases depressive symptoms in both young and older adults, with an increase in negative autobiographical memories in young adults, and a decrease in such memories in older adults. Our findings progress the understanding of the relationships between parental bonding and autobiographical memory with respect to emotional disorders, which, in turn, will help in the design of effective prevention measures.
False-positive classification and associated factors in segmented macular layers and retinal nerve fiber layer analysis: Spectralis OCT deviation map study
Authors: Lee Yun Jeong , Park Ki Ho , Jeoung Jin Wook 
Published: April 2023

AbstractThe rates, patterns and associated factors for false-positive classification of deviation maps by Cirrus optical coherence tomography (OCT) have been reported. However, research on OCT layer-by-layer deviation maps is lacking. We aimed to determine the rates and associated factors for false-positive classification of segmented macular layers and retinal nerve fiber layer (RNFL) deviation maps of Spectralis OCT, and to identify false-positive patterns on segmented macular layers deviation maps. 118 healthy eyes of 118 normal participants who had undergone Spectralis OCT imaging were included. False-positive classification was determined by the area and location of yellow or red color-coded regions on the deviation map. The false-positive rates on the deviation maps were the highest on the ganglion cell layer map, followed by the inner plexiform layer, retinal layer, and RNFL maps. More myopic/less hyperopic refractive error was a factor significantly associated with higher false-positive classification on the RNFL deviation map, and three false-positive patterns were found on the segmented macular layers deviation maps. Spectralis OCT deviation maps should be interpreted carefully to avoid misdiagnosis, especially for eyes with higher degrees of myopic refractive error on the RNFL map, for which purpose, recognizing the characteristic false-positive patterns would be helpful in clinical practice.
Prevalence, factors associated and knowledge of probable dementia among adults 50 years and over attending a faith-based geriatric center in Uganda
Authors: Awuol Machuor Daniel Arok , Innocent Besigye K. , Winfred Ayenyo 
Published: April 2023

AbstractDementia is on the rise due to increasing proportion of old people in sub-Saharan Africa (SSA). Although dementia is misattributed to normal ageing or supernatural causes in SSA, it is a brain disease with well-established etiologies. Limited knowledge and understanding of dementia means that many older people are suffering without seeking help and are undiagnosed and untreated. The aim of this study was to determine the prevalence and factors associated with probable dementia and to describe the knowledge of the disease among adults 50 years and over attending a faith-based geriatric center in Uganda. This was a cross-sectional study using quantitative methods. A total of 267 adults 50 years and over attending a faith-based geriatric center in Mukono, Uganda were interviewed between 1 April and 15 May 2022. Interviews were administered using the Early Dementia Questionnaire (EDQ) and Dementia Knowledge Assessment Scale (DKAS). Data on participants’ socio-demographics, economic income, living arrangement, history of smoking, alcohol consumption, exercise and past medical history was collected using an additional questionnaire. Adults 50 years and over were included in the study. Logistic regression analyses were done. Probable dementia was 46.2% in the sample. The most common symptoms of probable dementia in the order of their severity were memory symptoms, (β co-efficient β 0.08, p < .001), physical symptoms (β 0.08, p < .001), sleep disturbances (β 0.81, p < .001) and emotions (β 0.04, p < .027). The final degree of association as determined by adjusted PR in the multivariable model revealed that only older age (aPR = 1.88, p < .001) and occasional/non-believer (aPR = 1.61, p = .001) remained significantly related to probable dementia. The study also found that 8.0% of the participants had optimal knowledge of dementia. There is high burden of probable dementia among adults 50 years and over attending a faith-based geriatric center in Mukono, Uganda. Factors associated with probable dementia are older age and being an occasional/non-believer. Knowledge of dementia among older adults is low. There is need to promote integrated early dementia screening, care and educational program in primary care to reduce the disease burden. Spiritual support would be a rewarding investment in the lives of the ageing population.
Lead-free hybrid indium perovskites with near-unity PLQY and white light emission using an Sb3+doping strategy
Authors: Wu Ling-Kun , Li Ren-Fu , Wen Wei-Yang , Zou Qing-Hua , Ye Heng-Yun , Li Jian-Rong 
Published: April 2023

A series of new Sb3+ doped-(DETA)InCl6 organic–inorganic hybrid metal halide single crystals were synthesized. The PLQY of single crystals doped with 10% Sb was up to 100%, and white light emission was achieved when the Sb doping amount was 0.005%.
Analytical propagation on relative motion of geostationary earth orbit satellites with orbital perturbations
Authors: Zhang Dali , Li Li , Ma Guangcheng , Xia Hongwei , Wang Changhong 
Published: April 2023

AbstractAn accurate description of the relative motion of satellites is critical for space missions in the complex geostationary earth orbit space environment. Here, a new relative motion model is established considering major perturbations. To avoid the singularity of the classical orbital elements, a set of quasi‐non‐singular orbital elements are used to represent the relative motion states, which is further extended by considering the SRP coefficient difference. On the basis of existing classical model, an analytical model is derived by taking the Taylor expansion of the time derivative of the perturbation functions to the first order in the neighbourhood of the reference satellite, which contains the earth's oblateness perturbation, the third‐body perturbations and the solar radiation pressure perturbation. This method avoids solving the complex differential equations of relative motion directly and provides a general framework for including arbitrary perturbations into the model. The new model is verified in uncontrolled natural relative motion scenarios and position‐keeping control scenario, respectively. The results show that the proposed model has high accuracy and strong competitiveness.