bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phasic left atrial strain to predict worsening of diastolic function: Results from the prospective Berlin Female Risk Evaluation follow-up trial
Authors: Brand Anna , Romero Dorta Elena , Wolf Adrian , Blaschke-Waluga Daniela , Seeland Ute , Crayen Claudia , Bischoff Sven , Mattig Isabel , Dreger Henryk , Stangl Karl , Regitz-Zagrosek Vera , Landmesser Ulf , Knebel Fabian , Stangl Verena 
Published: February 2023

PurposeThe predictive value of maximum left atrial volume index (LAVI), phasic left atrial strain (LAS) and other standard echocardiographic parameters assessing left ventricular (LV) diastolic function to discriminate a future worsening of diastolic function (DD) in patients at risk is unclear. We aimed to prospectively assess and compare the clinical impact of these parameters in a randomly selected study sample of the general urban female population.Methods and resultsA comprehensive clinical and echocardiographic evaluation was performed in 256 participants of the Berlin Female Risk Evaluation (BEFRI) trial after a mean follow up time of 6.8 years. After an assessment of participants’ current DD status, the predictive impact of an impaired LAS on the course of DD was assessed and compared with LAVI and other DD parameters using receiver operating characteristic (ROC) curve and multivariate logistic regression analyses. Subjects with no DD (DD0) who showed a decline of diastolic function by the time of follow-up showed a reduced LA reservoir (LASr) and conduit strain (LAScd) compared to subjects who remained in the healthy range (LASr 28.0% ± 7.0 vs. 41.9% ± 8.5; LAScd −13.2% ± 5.1 vs. −25.4% ± 9.1; p &lt; 0.001). With an area under the curve (AUC) of 0.88 (95%CI 0.82–0.94) and 0.84 (95%CI 0.79–0.89), LASr and LAScd exhibited the highest discriminative value in predicting worsening of diastolic function, whereas LAVI was only of limited prognostic value [AUC 0.63 (95%CI 0.54–0.73)]. In logistic regression analyses, LAS remained a significant predictor for a decline of diastolic function after controlling for clinical and standard echocardiographic DD parameters, indicating its incremental predictive value.ConclusionThe analysis of phasic LAS may be useful to predict worsening of LV diastolic function in DD0 patients at risk for a future DD development.
Characteristics of azimuthal anisotropy in SE Tibetan plateau and its relationship with the background of block structure
Authors: Liu Jing , Wu Jianping , Fang Lihua , Chang Kai , Yang Ting , Wang Changzai , Wang Huaifu , Wang Shuang 
Published: February 2023

The southeastern Tibetan Plateau, which includes the Tibetan Plateau, Yangtze Block, and Cathaysia Block, is geotectonically situated in the compound part of the Tethys-Himalayan tectonic domain and the Peninsular Pacific tectonic domain. It is one of the critical regions for studying the scientific problems of plateau material lateral escape, lithosphere deformation, geotectonic properties of blocks, and deep dynamics. In this study, we use ambient noise data recorded by 401 broadband stations to obtain high-resolution short-period (T = 4–32 s) Rayleigh wave azimuthally anisotropic phase velocity maps. These could provide fresh clues for an in-depth understanding of the crust-mantle velocity structure, deformation mechanism, and geotectonic evolution in the southeastern Tibetan Plateau. Within the Simao block, the strikes of the faults and the orientations of the principal compressive stress of the stress field both generally coincide with the fast-wave polarization direction (FPD). The FPD near the Lancangjiang fault zone in the west is in the NE-SW direction, near the Wuliangshan fault zone in the center is near the NS direction, and near the Red River fault zone in the east is the NW-SE direction. We estimate that the compressive stress in the southwest direction of the Tibetan Plateau material has a controlling effect on the crustal deformation of the Simao block, which is likewise blocked by the Lincang granite belt, resulting in strong tectonic deformation. The FPD of the crust in the middle Red River fault zone is NS direction, significantly different from the fault strike. Combining with the seismic activity and GPS results, the depth of 8 km below the surface of the middle Red River fault is completely locked, and we conclude that the anisotropy of the upper crust of the middle part of the Red River fault zone is related to the action of the regional tectonic stress field. Taking into account geochemical and thermochemical results, we speculate that the complex tectonic stress at the junction of the blocks leads to prominent regional characteristics of the FPDs of azimuthal anisotropy in the crust, suggesting that the Shizong-Mile fault zone may be the western boundary between the Yangtze block and the Cathaysia block.
Depth migration of crustal-scale seismic reflection profiles: A case study in the Bohai Bay basin
Authors: Deng Xiaofan , Li Hongqiang , Gao Rui 
Published: February 2023

The application of the pre-stack depth migration (PSDM) method using deep seismic reflection data is still a challenge. In this paper, a deep seismic reflection dataset collected from the Bohai Bay Basin is used to test the applicability of the pre-stack depth migration method. After improving the signal-to-noise ratio of the prestack gathers and building an accurate velocity model capturing lateral and vertical variations, a high-quality pre-stack depth migration profile is obtained. This profile shows detailed crustal structures and an undulating Moho. The depth difference between the east and west sides of the Moho imaged in the profile is about 6 km. The Moho is disrupted by several discontinuities. Compared with conventionally stacked time-migration profiles, the pre-stack depth migration profile provides a higher-resolution subsurface image with accurate depth information. Combining geological and geophysical data, the pre-stack depth migration profile reveals geologic structures responsible for crust thinning during the destruction of the North China Craton. The profile also provides more accurate depth domain information for further study of crust-mantle interaction in this area.
Vitamin A regulates tissue-specific organ remodeling in diet-induced obesity independent of mitochondrial function
Authors: Shymotiuk Ivanna , Froese Natali , Werlein Christopher , Naasner Lea , Szaroszyk Malgorzata , Kühnel Mark P. , Jonigk Danny D. , Blaner William S. , Wende Adam R. , Abel E. Dale , Bauersachs Johann , Riehle Christian 
Published: February 2023

BackgroundPerturbed mitochondrial energetics and vitamin A (VitA) metabolism are associated with the pathogenesis of diet-induced obesity (DIO) and type 2 diabetes (T2D).MethodsTo test the hypothesis that VitA regulates tissue-specific mitochondrial energetics and adverse organ remodeling in DIO, we utilized a murine model of impaired VitA availability and high fat diet (HFD) feeding. Mitochondrial respiratory capacity and organ remodeling were assessed in liver, skeletal muscle, and kidney tissue, which are organs affected by T2D-associated complications and are critical for the pathogenesis of T2D.ResultsIn liver, VitA had no impact on maximal ADP-stimulated mitochondrial respiratory capacity (VADP) following HFD feeding with palmitoyl-carnitine and pyruvate each combined with malate as substrates. Interestingly, histopathological and gene expression analyses revealed that VitA mediates steatosis and adverse remodeling in DIO. In skeletal muscle, VitA did not affect VADP following HFD feeding. No morphological differences were detected between groups. In kidney, VADP was not different between groups with both combinations of substrates and VitA transduced the pro-fibrotic transcriptional response following HFD feeding.ConclusionThe present study identifies an unexpected and tissue-specific role for VitA in DIO that regulates the pro-fibrotic transcriptional response and that results in organ damage independent of changes in mitochondrial energetics.
The relationship between metabolic dysfunction-associated fatty liver disease and the incidence rate of extrahepatic cancer
Authors: Wei Suosu , Hao Yanrong , Dong Xiaofeng , Huang Junzhang , Huang Kai , Xie Yujie , Liu Hongjun , Wei Chunyu , Xu Jinan , Huang Wei , Dong Lingguang , Yang Jianrong 
Published: February 2023

BackgroundThe associations between metabolic dysfunction-associated fatty liver disease (MAFLD) and cancer development, especially extrahepatic cancers, are unknown. The aims of the current study were to investigate the cancer incidence rates of MAFLD and analyze the associations between MAFLD and the development of cancers.MethodsThis historical cohort study included participants who underwent ultrasonographic detection of hepatic steatosis at a tertiary hospital in China from January 2013 to October 2021. MAFLD was diagnosed in accordance with The International Expert Consensus Statement. Cox proportional hazards regression modeling was used to assess the associations between MAFLD and the development of cancers.ResultsOf the 47,801 participants, 16,093 (33.7%) had MAFLD. During the total follow-up of 175,137 person-years (median 3.3 years), the cancer incidence rate in the MAFLD group was higher than that in the non-MAFLD group [473.5 vs. 255.1 per 100,000 person-years; incidence rate ratio 1.86; 95% confidence interval (CI) 1.57–2.19]. After adjustment for age, gender, smoking status, and alcohol status, MAFLD was moderately associated with cancers of the female reproductive system/organs (labium, uterus, cervix, and ovary) [hazard ratio (HR) 2.24; 95% CI 1.09–4.60], thyroid (HR 3.64; 95% CI 1.82–7.30), and bladder (HR 4.19; 95% CI 1.15–15.27) in the total study cohort.ConclusionMAFLD was associated with the development of cancers of the female reproductive system/organs (labium, uterus, cervix, and ovary), thyroid, and bladder in the total study cohort.
The spatial and temporal distribution of China’s forest carbon
Authors: Cheng Fushan , Tian Jiaxin , He Jingyuan , He Huaijiang , Liu Guoliang , Zhang Zhonghui , Zhou Liping 
Published: February 2023

IntroductionChina’s forests have sequestrated a significant amount of carbon over the past two decades. However, it is not clear whether China’s forests will be able to continue to have as much carbon sequestration potential capacity in the future.MethodsIn order to research China’s forest carbon storage and carbon sequestration potential capacities at spatial and temporal scales, we built a digital forest model for each province of China using the data from The China Forest Resources Report (2014– 2018) and calculated the carbon storage capacity and sequestration potential capacity of each province with the current management practices without considering natural successions.ResultsThe results showed that the current forest carbon storage is 10.0 Pg C, and the carbon sequestration potential in the next 40 years (from year 2019 to 2058) will be 5.04 Pg C. Since immature forests account for the majority of current forests, the carbon sequestration capacity of the forest was also high (0.202 Pg C year−1). However, the forest carbon storage reached the maximum with the increase of stand maturity. At this time, if scenarios such as afforestation and reforestation, human and natural disturbances, and natural succession are not considered, the carbon sequestration capacity of forests will continue to decrease. After 90 years, all stands will develop into mature and over-mature forests, and the forest carbon sequestration capacity is 0.008 Pg year−1; and the carbon sequestration rate is ~4% of what it is nowadays. The change trend of forest carbon in each province is consistent with that of the country. In addition, considering the large forest coverage area in China, the differences in tree species and growing conditions, the forest carbon storage and carbon sequestration capacities among provinces were different. The growth rate of carbon density in high-latitude provinces (such as Heilongjiang, Jilin, and Inner Mongolia) was lower than that in the south (Guangdong, Guangxi, or Hunan), but the forest carbon potential was higher.DiscussionPlanning and implementing targeted forest management strategies is the key to increasing forest carbon storage and extending the service time of forest carbon sinks in provinces. In order to reach the national carbon neutrality goals, we recommend that each province have an informative strategic forest management plan.
Evolution trend and hot topic measurement of climate migration research under the influence of climate change
Authors: Liang Bing , Shi Guoqing , Sun Zhonggen , Babul Hossain , Zhou Min 
Published: February 2023

IntroductionGlobal climate change, which is characterized by climate warming, has become one of the most prominent risk problems in society at present. Climate migration brings many accompanying problems to the environment, economy, politics, society, and culture. It is of great theoretical and practical significance to study the internal relationship between climate change and population migration.MethodsThe data were extracted from the Web of Science core collection database (WOS) and China Knowledge Network database (CNKI). A total of 785 documents and 157 documents in the field of climate migration from 2008 to 2021 were selected as analysis samples. Word frequency analysis, clustering analysis, sudden word detection analysis, and other methods were extensively used to build the evolution trend map of climate migration using CiteSpace visual bibliometric software.ResultsIt is concluded that climate migration research has experienced three stages of development: initial exploration stage (2008-2011), development enrichment stage (2012-2017), and system deepening stage (2018).The hot topics of climate migration include: (1) different types of climate migration research; (2) Quantitative model research on climate migration; (3) Climate justice research. Different types of climate migration include 7 main types: (1) migration caused by sea level rise; (2) Resettlement caused by flood disaster; (3) Migration due to worsening drought; (4) Migration caused by extreme climate events; (5) Voluntary migration due to climate change discomfort; (6) Project resettlement caused by climate change response engineering measures; (7) Migrants whose livelihoods are broken due to climate change.DiscussionThe study points out that climate migration research is an interdisciplinary research field, which needs joint research by scholars from different academic backgrounds. In the future climate migration research, 1) strengthen the prediction ability of climate change population migration model; 2) Make use of China’s beneficial exploration in the migration fields such as engineering resettlement, ecological resettlement and poverty alleviation resettlement to formulate climate migration policies, regulations and strategic planning; 3) Establish a database cloud platform related to climate change and population migration; 4) Strengthen the exchange and cooperation between Chinese researchers in the field of climate migration and international scientific research institutions.
Development and validation of an endoplasmic reticulum stress long non-coding RNA signature for the prognosis and immune landscape prediction of patients with lung adenocarcinoma
Authors: Zeng Jie , Wu Zhenyu , Luo Meijuan , Xu Xie , Bai Wenjie , Xie Guijing , Chen Quhai , Liang Dengfeng , Xu Zixun , Chen Mindong , Xie Jianjiang 
Published: February 2023

Background: Lung adenocarcinoma (LUAD), the most common histotype of lung cancer, may have variable prognosis due to molecular variations. This work investigated long non-coding RNA (lncRNA) related to endoplasmic reticulum stress (ERS) to predict the prognosis and immune landscape for LUAD patients.Methods: RNA data and clinical data from 497 LUAD patients were collected in the Cancer Genome Atlas database. Pearson correlation analysis, univariate Cox regression, least absolute shrinkage and selection operator regression analyses, as well as the Kaplan-Meier method, were used to screen for ERS-related lncRNAs associated with prognosis. The risk score model was developed using multivariate Cox analysis to separate patients into high- and low-risk groups and a nomogram was constructed and evaluated. Finally, we explore the potential functions and compared the immune landscapes of two groups. Quantitative real-time PCR was used to verify the expression of these lncRNAs.Results: Five ERS-related lncRNAs were shown to be strongly linked to patients’ prognosis. A risk score model was built by using these lncRNAs to categorize patients based on their median risk scores. For LUAD patients, the model was found to be an independent prognostic predictor (p &lt; 0.001). The signature and clinical variables were then used to construct a nomogram. With 3-year and 5-year OS’ AUC of 0.725 and 0.740, respectively, the nomogram’s prediction performance is excellent. The 5-lncRNA signature was associated with DNA replication, epithelial-mesenchymal transition, and the pathway of cell cycle, P53 signaling. Between the two risk groups, immune responses, immune cells, and immunological checkpoints were found to be considerably different.Conclusion: Overall, our findings indicate that the 5 ERS-related lncRNA signature was an excellent prognostic indicator and helped to predict the immunotherapy response for patients with LUAD.
Prevalence of sexual violence and associated factors among women attending antenatal care in Debre Markos at public health institutions in north-west Ethiopia, 2021
Authors: Abegaz Marta Yimam , Muche Haymanot Alem , Aynalem Getie Lake , Anteneh Tazeb Alemu , Tibebu Nebyu Solomon , Gedef Getachew Muluye , Mengstie Aregash Sitot 
Published: February 2023

BackgroundSexual violence refers to being forced to perform any unwanted sexual act. Due to the negative effects on both the mother and the fetus, sexual assault during pregnancy is a public health concern. Knowing the prevalence of sexual violence during pregnancy helps policymakers understand the extent of the problem and can be considered the first step toward implementing interventions for prevention and treatment. This study was done to determine the prevalence of sexual violence and its associated factors during pregnancy in public hospitals in Debre Markos.MethodsAn institution-based cross-sectional study was conducted among 306 pregnant women in Debre Markos, north west Ethiopia from May 1 to June 30, 2021, 2021. A systematic random sampling procedure was used to select study participants. Data were collected using a structured and interviewer-administered questionnaire, and a pre-test was done. Both bi-variable and multivariable logistic regression analyses were undertaken to identify significantly associated variables with sexual violence. The adjusted odds ratio (AOR) with its 95% confidence interval (CI) at a p-value of ≤ 0.05 was used to claim statistical association.ResultsThere were 304 interviewed respondents with a response rate of 99.3%. In this study, the overall prevalence of sexual violence among pregnant mothers during the current pregnancy was 19.4%. A husband who had no formal education {AOR = 3.48; 95% CI: 1.06, 11.39}, pregnant mothers who had no formal education {AOR =  6.1; 95% CI: 1.50–18.11}, pregnant mothers who had secondary education {AOR = 2.80, 95% CI: 1.15, 6.81}, being a housewife {AOR = 3.87, 95 CI:1.21, 12.37}, and being a governmental employee {AOR = 4.49, 95% CI: 1.22, 16.40} were factors associated with sexual violence at the value of p ≤ 0.05.Conclusions and recommendationsIn this study, approximately one-fifth of the study participants experienced sexual violence during their current pregnancy. To reduce this, interventions should focus on the education of women as well as their partner about violence against women and on initiatives to economically empower women.
SARS-COV-2 viroporins activate the NLRP3-inflammasome by the mitochondrial permeability transition pore
Authors: Guarnieri Joseph W. , Angelin Alessia , Murdock Deborah G. , Schaefer Patrick , Portluri Prasanth , Lie Timothy , Huang Jessica , Wallace Douglas C. 
Published: February 2023

BackgroundCompared to healthy controls, severe COVID19 patients display increased levels of activated NLRP3-inflammasome (NLRP3-I) and interleukin (IL)-1β. SARS-CoV-2 encodes viroporin proteins E and Orf3a(2-E+2-3a) with homologs to SARS-CoV-1, 1-E+1-3a, which elevate NLRP3-I activation; by an unknown mechanism. Thus, we investigated how 2-E+2-3a activates the NLRP3-I to better understand the pathophysiology of severe COVID-19.MethodsWe generated a polycistronic expression-vector co-expressing 2-E+2-3a from a single transcript. To elucidate how 2-E+2-3a activates the NLRP3-I, we reconstituted the NLRP3-I in 293T cells and used THP1-derived macrophages to monitor the secretion of mature IL-1β. Mitochondrial physiology was assessed using fluorescent microscopy and plate reader assays, and the release of mitochondrial DNA (mtDNA) was detected from cytosolic-enriched fractions using Real-Time PCR.ResultsExpression of 2-E+2-3a in 293T cells increased cytosolic Ca++ and elevated mitochondrial Ca++, taken up through the MCUi11-sensitive mitochondrial calcium uniporter. Increased mitochondrial Ca++ stimulated NADH, mitochondrial reactive oxygen species (mROS) production and the release of mtDNA into the cytosol. Expression of 2-E+2-3a in NLRP3-I reconstituted 293T cells and THP1-derived macrophages displayed increased secretion of IL-1β. Increasing mitochondrial antioxidant defenses via treatment with MnTBAP or genetic expression of mCAT abolished 2-E+2-3a elevation of mROS, cytosolic mtDNA levels, and secretion of NLRP3-activated-IL-1β. The 2-E+2-3a-induced release of mtDNA and the secretion of NLRP3-activated-IL-1β were absent in cells lacking mtDNA and blocked in cells treated with the mitochondrial-permeability-pore(mtPTP)-specific inhibitor NIM811.ConclusionOur findings revealed that mROS activates the release of mitochondrial DNA via the NIM811-sensitive mitochondrial-permeability-pore(mtPTP), activating the inflammasome. Hence, interventions targeting mROS and the mtPTP may mitigate the severity of COVID-19 cytokine storms.