bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gerenciamento de Impressões pelos Gestores: Uma Perspectiva Sobre A Satisfação Laboral
Authors: Valadares João Paulo de Assis , Nascimento Eduardo Mendes , Amaral Leonardo Barbosa , Da Cunha Jacqueline Veneroso Alves , Pinto Diego Henrique Salgueiro 
Published: May 2023

O objetivo geral dessa pesquisa foi analisar a relação existente entre o gerenciamento de impressões dos gestores e a satisfação dos colaboradores no ambiente de trabalho. Adicionalmente, procurou-se verificar se existiam relações entre o gerenciamento de impressões e as variáveis descritivas dos gestores, como sexo, idade e estado civil. Para o levantamento de dados foram utilizados dois instrumentos (um para os gestores e outro para seus liderados). A composição da amostra do presente estudo foi feita por conveniência, por meio da técnica de bola de neve. Participaram deste estudo 32 gestores de escritórios contábeis e 67 dos seus funcionários. Os dados da amostra levantada evidenciaram que o gerenciamento de impressão dos gestores e a satisfação laboral apresentam associações fracas e não significativas naquele contexto. Porém, foi possível identificar associação significativa entre a satisfação laboral e variáveis descritivas das empresas analisadas. Os resultados indicam a necessidade dos gestores de refletir sobre a forma como estão se utilizando do Gerenciamento de Impressões (GI), pois tais resultados indicam a pouca efetividade do GI para otimizar a satisfação dos seus liderados. Nesse sentido, não se recomenda a eliminação das técnicas de GI, mas a sua utilização de modo a transmitir uma imagem sincera de simpatia, competência e moralmente confiáveis. Pois, assim, sinalizaria para a quebra de um estereótipo ao indicar que a satisfação laboral está mais relacionada à estrutura e ambiente das entidades do que à imagem pessoal que os gestores tentam construir. Essa perspectiva tende a proporcionar a melhoria do clima organizacional, pois indica que os indivíduos poderiam se dedicar mais às suas atividades laborais, possibilitando ganhos de produtividade e, ainda, que eles poderiam agir de modo mais natural, o que resultaria em menos tensão, considerando que não haveria a necessidade de automonitoramento constante pela busca da imagem ideal.
Efficacy and Safety of Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist Danuglipron for Glycemic Control Among Patients With Type 2 Diabetes
Authors: Saxena Aditi R. , Frias Juan P. , Brown Lisa S. , Gorman Donal N. , Vasas Szilard , Tsamandouras Nikolaos , Birnbaum Morris J. 
Published: May 2023

ImportanceCurrently available glucagon-like peptide 1 receptor (GLP-1R) agonists for treating type 2 diabetes (T2D) are peptide agonists that require subcutaneous administration or strict fasting requirements before and after oral administration.ObjectiveTo investigate the efficacy, safety, and tolerability of multiple dose levels of the novel, oral, small molecule GLP-1R agonist danuglipron over 16 weeks.Design, Setting, and ParticipantsA phase 2b, double-blind, placebo-controlled, parallel-group, 6-group randomized clinical trial with 16-week double-blind treatment period and 4-week follow-up was conducted from July 7, 2020, to July 7, 2021. Adults with T2D inadequately controlled by diet and exercise, with or without metformin treatment, were enrolled from 97 clinical research sites in 8 countries or regions.InterventionsParticipants received placebo or danuglipron, 2.5, 10, 40, 80, or 120 mg, all orally administered twice daily with food for 16 weeks. Weekly dose escalation steps were incorporated to achieve danuglipron doses of 40 mg or more twice daily.Main Outcomes and MeasuresChange from baseline in glycated hemoglobin (HbA1c, primary end point), fasting plasma glucose (FPG), and body weight were assessed at week 16. Safety was monitored throughout the study period, including a 4-week follow-up period.ResultsOf 411 participants randomized and treated (mean [SD] age, 58.6 [9.3] years; 209 [51%] male), 316 (77%) completed treatment. For all danuglipron doses, HbA1c and FPG were statistically significantly reduced at week 16 vs placebo, with HbA1c reductions up to a least squares mean difference vs placebo of −1.16% (90% CI, −1.47% to −0.86%) for the 120-mg twice daily group and FPG reductions up to a least squares mean difference vs placebo of −33.24 mg/dL (90% CI, −45.63 to −20.84 mg/dL). Body weight was statistically significantly reduced at week 16 compared with placebo in the 80-mg twice daily and 120-mg twice daily groups only, with a least squares mean difference vs placebo of −2.04 kg (90% CI, −3.01 to −1.07 kg) for the 80-mg twice daily group and −4.17 kg (90% CI, −5.15 to −3.18 kg) for the 120-mg twice daily group. The most commonly reported adverse events were nausea, diarrhea, and vomiting.Conclusions and RelevanceIn adults with T2D, danuglipron reduced HbA1c, FPG, and body weight at week 16 compared with placebo, with a tolerability profile consistent with the mechanism of action.Trial RegistrationClinicalTrials.gov Identifier: NCT03985293
Fuzzy cognitive mapping as a tool to assess the relative cumulative effects of environmental stressors on an Arctic seabird population to identify conservation action and research priorities
Authors: Rooney Rebecca C. , Daniel Jody , Mallory Mark , Hedd April , Ives Jess , Gilchrist Grant , Gjerdrum Carina , Robertson Greg , Ronconi Rob , Wilcox Kirsten , Wong Sarah , Provencher Jennifer 
Published: May 2023

Abstract

In the Arctic, chemical contaminants, shipping, oil pollution, plastic pollution, changing habitats in relation to climate change and fisheries have been identified as environmental stressors to seabirds such as Fulmarus glacialis (northern fulmar; qaqulluk; ᖃᖁᓪᓗᖅ), but rarely have these stressors been considered within a cumulative effects framework in this species which is currently showing a declining populations trend.

As a novel tool to understand cumulative effects within a conservation context, we applied a fuzzy cognitive mapping (FCM) approach that allows experts to arrange key factors and their interrelationships, organizing their understanding of the components of a complex issue into a graphical representation; a ‘cognitive map’.

This process was grounded in local environment concerns as documented in several Nunavut‐specific reports and discussions, and worked with western‐trained seabird experts with knowledge of northern fulmar populations to assess the inter‐related environmental threats to fulmars as a way to combine these stressors in a cumulative effects framework and identify conservation actions and knowledge gaps.

We found strong agreement that the main stressors affecting northern fulmar populations in Canada include pollution (11% total influence (TI)), shipping activities (16% TI), hunting and fishing (18% TI) and mining/oil and gas exploitation activities (22% TI).

The indirect influence of threats on northern fulmar population size (57% TI) exceeded the total direct influence (43% TI), emphasizing the value of cognitive mapping in cumulative effects assessment for a more holistic understanding of interacting stressors.

Participants expressed substantial uncertainty regarding the strong relationships leading from the concepts, commercial fishing activity in the BBDS and the North Atlantic fisheries activity, indicating that these potential stressors require more research.

Similarly, uncertainty was expressed about the potential effects of zodiac traffic, ship strikes of northern fulmar, number of oil spills and magnitude of oil spills on northern fulmar.

By characterizing individual factors as manageable or not, we determined that stressors are largely manageable with enforcement of existing policies (58% TI)—importantly, fishing activities were both highly influential on fulmars and deemed manageable, which will inform ongoing co‐management planning in the region.
Utilizing Parasitic Capacitance of Single‐Droplet Electricity Generator For Specific Bacterial Detection
Authors: Wang Congyu , Wang Peng , Li Jiawei , Sun Yihan , Lu Wei , Zhang Dun , Wan Yi , Ai Shiyun 
Published: May 2023

AbstractSingle‐droplet electricity generator (SDEG) has superior potential over other solid–liquid triboelectric nanogenerators (TENGs) for energy harvesting. However, its shunting effect of parasitic capacitance is adverse and unavoidable, resulting in the reduction of the SDEG voltage. In addition, TENG‐based bacterial biosensors are still facing issues of incompetence in resolution, precision, and specificity. Therefore, a novel SDEG‐based bacterial biosensor is developed by making use of parasitic capacitance. By taking the advantages of aptamer and parasitic capacitance, the Pseudomonas aeruginosa (P. aeruginosa) can be specifically and precisely detected via signal change from a single droplet without energy accumulation. This study proves that the SDEG‐based bacterial biosensor exhibits an excellent performance for P. aeruginosa detection in low limit of detection (4.5×103 CFU mL−1) with high selectivity. Meanwhile, the established mathematical model yields consistent results to the experimental ones, which serves as a solid basis for quantifying bacterial concentration. This work contributes to TENG‐based bacterial biosensor, and opens up a new way for the diversified application of SDEG.
Tunable Organic Active Neural Probe Enabling Near‐Sensor Signal Processing
Authors: Lee Yongwoo , Carnicer‐Lombarte Alejandro , Han Sanggil , Woodington Ben J. , Chai Seungjin , Polyravas Anastasios G. , Velasco‐Bosom Santiago , Kim Eun‐Hee , Malliaras George G. , Jung Sungjune 
Published: May 2023

AbstractNeural recording systems have significantly progressed to provide an advanced understanding and treatment for neurological diseases. Flexible transistor‐based active neural probes exhibit great potential in electrophysiology applications due to their intrinsic amplification capability and tissue‐compliant nature. However, most current active neural probes exhibit bulky back‐end connectivity since the output is current, and the development of an integrated circuit for voltage output is crucial for near‐sensor signal processing at the abiotic/biotic interface. Here, inkjet‐printed organic voltage amplifiers are presented by monolithically integrating organic electrochemical transistors and thin‐film polymer resistors on a single, highly flexible substrate for in vivo brain activity recording. Additive inkjet printing enables the seamless integration of multiple active and passive components on the somatosensory cortex, leading to significant noise reduction over the externally connected typical configuration. It also facilitates fine‐tuning of the voltage amplification and frequency properties. The organic voltage amplifiers are validated as electrocorticography devices in a rat in vivo model, showing their ability to record local field potentials in an experimental model of spontaneous and epileptiform activity. These results bring organic active neural probes to the forefront in applications where efficient sensory data processing is performed at sensor endpoints.
Enabling Highly Efficient and Thermal‐Stable Polymer Solar Cells through Semi‐Alloy Acceptors Composed of a Hinge‐Like Dimer: A Versatile Doping Protocol
Authors: Wan Ji , Wang Tao , Sun Rui , Wu Xiaohei , Wang Shanshan , Zhang Meimei , Min Jie 
Published: May 2023

AbstractThe simultaneous improvement of power conversion efficiency (PCE) and thermal stability is a critical scientific challenge in advancing the commercial applications of polymer solar cells. To address this challenge, a dumbbell‐shaped dimeric acceptor, DT19, is successfully designed and synthesized. It is incorporated as a third component into the PM1:BTP‐eC9 system. This ternary strategy demonstrates a synergistic enhancement of the PCE and thermal stability of the host binary system. In particular, the PM1:BTP‐eC9:DT19 system maintains a PCE of over 90% even after heating at 120 °C for 200 h. Additionally, the dimer‐doping ternary strategy exhibits excellent generality for the other four Y‐series systems and outperforms ternary systems containing alloy‐like acceptors in terms of thermal stability. It is because DT19, with its hinge‐like structure, can form a semi‐alloy acceptor with the host acceptor, leading to strong interchain entanglement with the polymer donor, thus overcoming phase separation and excessive aggregation under thermal stress. This new type of dimeric material, which can synergistically enhance the device efficiency and thermal stability of active layers, presents promising application prospects.
InP Semiconductor Nanocrystals: Synthesis, Optical Properties, and Applications
Authors: Liu Huan , Chen Peixian , Cui Yanyan , Gao Yang , Cheng Jiaji , He Tingchao , Chen Rui 
Published: May 2023

AbstractAs the most promising candidate for luminescent semiconductor materials in the future environmentally friendly society, InP nanocrystals (NCs) have attracted strong attention in the past decade. Tremendous efforts have been devoted to address the unstable and poor optical properties of InP NCs for practical applications. An extensive and in‐depth summary of existing literatures can not only provide an important reference for further optimizing of the optical properties of InP NCs, but also lay a foundation for subsequent related applications. In this review, the methods for the synthesis with different P sources and different ZnE (E = Se, S) shells are briefly summarized. The research progress in the optical properties investigation of InP/ZnE and InP/ZnE/ZnE NCs, including absorption, fluorescence, carrier dynamics, and nonlinear optics, are summarized. The relevant applications based on InP/ZnE and InP/ZnE/ZnE NCs are also presented, ranging from light emitting diodes, bioimaging, and solar cells to photocatalytic hydrogen production.
Electrochemically Promoted Oxydifluoroethylation of Alkenes for the Synthesis of Difluoroethylated Benzoxazines and Lactones
Authors: Tian Yunfei , Zheng Luping , Yang Yuting , Liu Jiayi , Jing Zihan , Li Zejiang , Fu Weijun 
Published: May 2023

AbstractAn electrochemical oxydifluoroethylation of alkenes involving the anodic oxidative generation of MeCF2 radical has been achieved, which enabled to construct diversified difluoroethylated benzoxazines and lactones in 35–87% yields. Moreover, the developed protocol was also extended to the synthesis of cyclopropyldifluoromethylated benzoxazines. Detailed mechanistic studies indicated the reaction underwent a radical process concerned with tandem C−CF2R and C−O bond formation.
Strategies and Methods for the Synthesis of 2‐Pyrazolines: Recent Developments (2012–2022)
Authors: Matiadis Dimitris 
Published: May 2023

Abstract2‐Pyrazolines are important five‐membered heterocycles, containing two adjacent nitrogen atoms. They can incorporate various functional groups and possess unique biological properties. Moreover, they have been used as useful building blocks. In recent years, the field of 2‐pyrazoline synthesis has experienced enormous progress. Novel strategies have been developed, and many studies reporting improvements or adaptations of existing protocols have been published, giving access to new functionalizations, unexplored structures, and/or enantioselective synthesis. This review summarizes the progress made in synthetic methodologies during the period from 2012 to 2022. The functionalization challenges and capabilities, scopes and limitations of the reactions, substitution patterns, and mechanisms of the reactions, where appropriate, will be discussed.
Carbon Nanocluster‐Mediated Nanoblending Assembly for Binder‐Free Energy Storage Electrodes with High Capacities and Enhanced Charge Transfer Kinetics
Authors: Song Yongkwon , Bae Woojin , Ahn Jeongyeon , Son Youhyun , Kwon Minseong , Kwon Cheong Hoon , Kim Younghoon , Ko Yongmin , Cho Jinhan 
Published: May 2023

AbstractThe effective spatial distribution and arrangement of electrochemically active and conductive components within metal oxide nanoparticle (MO NP)‐based electrodes significantly impact their energy storage performance. Unfortunately, conventional electrode preparation processes have much difficulty addressing this issue. Herein, this work demonstrates that a unique nanoblending assembly based on favorable and direct interfacial interactions between high‐energy MO NPs and interface‐modified carbon nanoclusters (CNs) notably enhances the capacities and charge transfer kinetics of binder‐free electrodes in lithium‐ion batteries (LIBs). For this study, carboxylic acid (COOH)‐functionalized carbon nanoclusters (CCNs) are consecutively assembled with bulky ligand‐stabilized MO NPs through ligand‐exchange‐induced multidentate binding between the COOH groups of CCNs and the surface of NPs. This nanoblending assembly homogeneously distributes conductive CCNs within densely packed MO NP arrays without insulating organics (i.e., polymeric binders and/or ligands) and prevents the aggregation/segregation of electrode components, thus markedly reducing contact resistance between neighboring NPs. Furthermore, when these CCN‐mediated MO NP electrodes are formed on highly porous fibril‐type current collectors (FCCs) for LIB electrodes, they deliver outstanding areal performance, which can be further improved through simple multistacking. The findings provide a basis for better understanding the relationship between interfacial interaction/structures and charge transfer processes and for developing high‐performance energy storage electrodes.
Advanced Oxidation Nanoprocessing Boosts Immunogenicity of Whole Tumor Cells
Authors: Zhang Min , Huang Yiming , Zou Jie , Yang Yang , Yao Yue , Cheng Guofeng , Yang Yannan 
Published: May 2023

AbstractWhole tumor cells expressing a wide array of tumor antigens are considered as a highly promising source of antigens for cancer vaccines. However, simultaneously preserving the antigen diversity, improving immunogenicity, and eliminating the potential tumorigenic risk of whole tumor cells are highly challenging. Inspired by the recent progress in sulfate radical‐based environmental technology, herein, an advanced oxidation nanoprocessing (AONP) strategy is developed for boosting the immunogenicity of whole tumor cells. The AONP is based on the activation of peroxymonosulfate by ZIF‐67 nanocatalysts to produce SO4−∙ radicals continuously, leading to sustained oxidative damage to tumor cells and consequently extensive cell death. Importantly, AONP causes immunogenic apoptosis as evidenced by the release of a series of characteristic damage associated molecular patterns and at the same time maintains the integrity of cancer cells, which is critical to preserve the cellular components and thus maximize the diversity of antigens. Finally, the immunogenicity of AONP‐treated whole tumor cells is evaluated in a prophylactic vaccination model, demonstrating significantly delayed tumor growth and increased survival rate of live tumor‐cell‐challenged mice. It is expected that the developed AONP strategy would pave the way to develop effective personalized whole tumor cell vaccines in future.
Nitrogen mineralization following fall‐applied compost to subsurface drip‐irrigated processing tomatoes in California
Authors: Fulford Anthony M. , Wang Zheng , Zavalloni Costanza 
Published: May 2023

AbstractOrganic wastes diverted from landfills can reduce greenhouse gas emissions and are used as supplemental nutrient sources for agricultural crops after they are composted. In California, compost should be applied in the fall to processing tomatoes (Solanum lycopersicum L.) to avoid delaying field preparation and transplanting in the spring. The objective of this study was to determine soil nitrogen (N) mineralization following fall application of greenwaste compost (GWC) based on the change of mineral N during a 4 month in‐field buried bag soil incubation in 2 prospective subsurface drip‐irrigated processing tomato fields (PTF1 and PTF2). GWC rates of 0, 11, 22, and 34 Mg ha−1 were evaluated in PTF1 and PTF2 in October 2019. Very dry surface soil conditions in fall 2019 and the disruptive procedure used to prepare soil for in‐field incubation using the buried bag method led us to calculate net N mineralization after adjusting for the initial mineral N concentration of the unamended (0 Mg ha−1) control. The adjusted net N mineralization was significantly less in PTF1 (8.6 mg N kg−1) than PTF2 (16.4 mg N kg−1) and the estimated net N mineralization rate of the surface 0–15 cm soil depth following GWC application to PTF1 was less than PTF2 (1.6–1.9 vs. 2.3–3.1 kg N ha−1 week−1). In‐field incubation requires soil disturbance that likely affected N mineralization and additional research should consider the feasibility of using pretreatments or pre‐incubations to account for disruption to antecedent soil conditions.
Retrospective identification of patients with SRRM2‐related neurodevelopmental disorder in a single tertiary children's hospital
Authors: Regan‐Fendt Kelly E. , Rippert Alyssa L. , Medne Livija , Skraban Cara M. , DeJesse Jeshua , Gray Christopher , Reichert Sara L. , Staropoli Nicholas P. , Santos Francis Jeshira Reynoso , Krantz Ian D. , Murrell Jill R. , Izumi Kosuke 
Published: May 2023

AbstractSRRM2‐related neurodevelopmental disorder is a recently described genetic diagnosis caused by loss‐of‐function variants in SRRM2. In order to understand the clinical spectrum of SRRM2‐related neurodevelopmental disorder, we performed a retrospective exome data and clinical chart review at a single tertiary children's hospital, Children's Hospital of Philadelphia (CHOP). Among approximately 3100 clinical exome sequencing cases performed at CHOP, we identified three patients with SRRM2 loss‐of‐function pathogenic variants, in addition to one patient previously described in the literature. Common clinical features include developmental delay, attention deficit hyperactivity disorder, macrocephaly, hypotonia, gastroesophageal reflux, overweight/obesity, and autism. While developmental disabilities are commonly seen in all individuals with SRRM2 variants, the degree of developmental delay and intellectual disability is variable. Our data suggest that SRRM2‐related neurodevelopmental disorder can be identified in 0.3% of individuals with developmental disabilities receiving exome sequencing.