bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time to relapse in chronic lymphocytic leukemia and DNA-methylation-based biological age
Authors: Nannini Drew R. , Cortese Rene , Egwom Peter , Palaniyandi Senthilnathan , Hildebrandt Gerhard C. 
Published: May 2023

AbstractChronic lymphocytic leukemia (CLL) is a mature B cell neoplasm with a predilection for older individuals. While previous studies have identified epigenetic signatures associated with CLL, whether age-related DNA methylation changes modulate CLL relapse remains elusive. In this study, we examined the association between epigenetic age acceleration and time to CLL relapse in a publicly available dataset. DNA methylation profiling of 35 CLL patients prior to initiating chemoimmunotherapy was performed using the Infinium HumanMethylation450 BeadChip. Four epigenetic age acceleration metrics (intrinsic epigenetic age acceleration [IEAA], extrinsic epigenetic age acceleration [EEAA], PhenoAge acceleration [PhenoAA], and GrimAge acceleration [GrimAA]) were estimated from blood DNA methylation levels. Linear, quantile, and logistic regression and receiver operating characteristic curve analyses were conducted to assess the association between each epigenetic age metric and time to CLL relapse. EEAA (p = 0.011) and PhenoAA (p = 0.046) were negatively and GrimAA (p = 0.040) was positively associated with time to CLL relapse. Simultaneous assessment of EEAA and GrimAA in male patients distinguished patients who relapsed early from patients who relapsed later (p = 0.039). No associations were observed with IEAA. These findings suggest epigenetic age acceleration prior to chemoimmunotherapy initiation is associated with time to CLL relapse. Our results provide novel insight into the association between age-related DNA methylation changes and CLL relapse and may serve has biomarkers for treatment relapse, and potentially, treatment selection.
Coral fauna across the Cretaceous–Paleogene boundary at Zagros and Sistan Suture zones and Yazd Block of Iran
Authors: Baron-Szabo Rosemarie C. , Schlagintweit Felix , Rashidi Koorosh 
Published: May 2023

AbstractFrom the upper Maastrichtian (Tarbur Fm.) and Paleocene of Iran, 20 species of scleractinian corals belonging to 17 genera and 14 families, and one species of the octocoral Heliopora are newly recorded. Furthermore, coral species previously described from the upper Maastrichtian Tarbur Fm. and the Paleocene are revised and included in the evaluation, resulting in a total of 37 species from 28 genera belonging to 20 families (including 3 subfamilies) for the Iranian K/Pg-boundary time period. The majority of the taxa (21 out of 37 = 57%) crossed the K/Pg-boundary. The genera Acropora and Stylocoeniella are recorded from strata older than the Paleogene (upper Maastrichtian) for the first time; for Lobopsammia it is the first report from strata older than the Eocene (Selandian‒Thanetian). The vast majority of the coral taxa occurring in both the upper Maastrichtian (Tarbur Fm.) and the Paleocene of Iran have been reported from a variety of both reefal and non-reefal paleoenvironments. On the species level, a slight majority of the corals from the upper Maastrichtian (Tarbur Fm.) are endemic (14 out of 27 species = 52%). In contrast, the vast majority of the Paleocene Iranian corals are cosmopolitan to subcosmopolitan; only 4 taxa are endemic during the Paleocene. While the upper Maastrichtian coral fauna of Iran shows greatest affinities to contemporaneous assemblages of Europe and the Caribbean, the Paleocene coral fauna is most closely related to contemporaneous coral associations of central Asia, Europe, and North America.
Mean-field optimal control in a multi-agent interaction model for prevention of maritime crime
Authors: Orlando Gianluca 
Published: May 2023

AbstractWe study a multi-agent system for the modeling maritime crime. The model involves three interacting populations of ships: commercial ships, pirate ships, and coast guard ships. Commercial ships follow commercial routes, are subject to traffic congestion, and are repelled by pirate ships. Pirate ships travel stochastically, are attracted by commercial ships and repelled by coast guard ships. Coast guard ships are controlled. We prove well-posedness of the model and existence of optimal controls that minimize dangerous contacts. Then we study, in a two-step procedure, the mean-field limit as the number of commercial ships and pirate ships is large, deriving a mean-field PDE/PDE/ODE model. Via Γ-convergence, we study the limit of the corresponding optimal control problems.
What is public health? a scoping review
Authors: Azari Razieh , Borisch Bettina 
Published: May 2023

Abstract
Background
during the last hundred years, several major public health issues have already afflicted humanity. Most frequently cited definitions of public health have stemmed from long-standing definitions, which raises several concerns including whether these definitions can respond to today’s public health challenges. The present study aimed to identify and review available public health definitions in the first place.

Methods
in this scoping review, we undertook an electronic search in four databases (PubMed, Web of Science, Embase, and EBSCOhost) from inception until June 06, 2022, and a grey literature search in Google Scholar. Moreover, reference lists of publications included in the scoping review were screened manually for additional relevant publications. All types of scientific publications, in English, that focused on the definition of public health and provided an original definition were included. Year, type, disciplinary fields of publications, objectives of publications, and public health definitions were extracted.

Results
5651 publications were identified through the scoping search, of which five were subjected to full-text review. Of these publications, two were included. An additional nine publications were identified through the manual screening. A total 11 of publications were included in the scoping review. Of the 11 definitions included in this review, the latest original definitions date back to about two decades ago.

Conclusions
there is a noticeable lack of updated definitions of public health. Considering our findings and the ever-changing nature of public health issues, there is an urgent need for re-assessing and updating public health definitions.
Multidisciplinary physician survey assessing knowledge of the female athlete triad and relative energy deficiency in sport
Authors: Warrick Alexandra E. , Hassid Brandon , Coleman Brandon , Cansino Catherine , Faustin Marcia 
Published: May 2023

AbstractBackgroundShort and long-term health consequences surrounding Low Energy Availability can be mitigated by recognizing the risk factors and making early diagnosis of the Female Athlete Triad (Triad) and Relative Energy Deficiency in Sport (RED-S). While awareness of the Triad among physicians and allied health professionals has been studied, there are very few studies that assess physician awareness of both the Triad and RED-S.MethodsOur study assesses Low Energy Availability, the Triad, and RED-S knowledge with an electronic survey, educational handout, and follow up survey among physicians across multiple specialties at a single academic institution.ResultsAmong 161 respondents, respective Triad and RED-S awareness among surveyed specialties was highest in Orthopedic surgeons (100%, 100%), followed by Physical Medicine & Rehabilitation (70%, 53%), Family Medicine (67%, 48%), Internal Medicine (54%, 36%), Obstetrics and Gynecology (46%, 32%), Pediatrics (45%, 29%), Endocrinology (33%, 33%), and Other (33%, 33%). Comparing the initial survey results to the follow-up survey results, there was an increase from 37 to 72% of physicians who correctly identified that the presence of low BMI or recent weight loss is not a required component of the Triad or RED-S. Both the initial and follow-up survey revealed a continued misperception surrounding the use of hormonal contraception to resume menstrual cycles, with 33% of physicians on initial survey and 44% of physicians on follow-up survey incorrectly answering that question.ConclusionsMultidisciplinary physicians have various levels of knowledge surrounding the Triad and RED-S, and there is a need for improved physician awareness, diagnosis, and treatment of the Triad and RED-S. Misperceptions exist surrounding the role of hormonal contraception in female athletes with the Triad and RED-S to regain and regulate menses.
From agricultural waste to chicken feed using insect-based technology
Authors: Dzepe Daniel , Kuietche Hervé Mube , Magatsing Ornela , Meutchieye Félix , Nana Paulin , Tchuinkam Timoléon , Djouaka Rousseau 
Published: May 2023

AbstractBackgroundThis study investigates the potential of black soldier fly (BSF) larvae to recycle agricultural waste into larval biomass for chicken feed, and was carried out at the University of Dschang, Cameroon in 2020. Fruit waste consisting of papaya, pineapple and orange peels, and cocoa pods from local sources were used for this study. They were first grinded, and the fruit waste was subjected directly to the larvae from a pre-established BSF colony. Cocoa pods on the other hand were mixed withTithonialeaves at 0% (C100:T0), 5% (C95:T5), 10% (C90:T10), 15% (C85:T15) and 20% (C80:T20), and larval recycling efficiency was assessed using bioconversion parameters. At the end of the process, the BSF larvae from the fruit waste were harvested, dried, grinded, and used in chicken diet as a source of dietary protein. Their nutritional effect was assessed using chicken growth parameters.ResultsWithin 15 days, BSF larvae were able to reduce fruit waste by 96.05% and generated 125.33 g of fresh larvae, with an average bioconversion rate of 08.35%. The recycling efficiency of cocoa pods has been greatly improved with the incorporation of Tithonia leaves. The highest bioconversion rate was recorded with the C80:T20 treatment (17.2%). The larvae produced were concentrated in proteins, lipids, and minerals. Those harvested from recycling fruit waste consisted of 39.50% protein, 19.84% lipid and 10.37% ash. Their incorporation in chicken diet as a source of animal protein did not reveal any negative effects on the growth parameters. The growth performances recorded were comparable to that of commonly used fishmeal.ConclusionsBSF larvae can easily be reared on agricultural waste to replace or supplement fishmeal in chicken diet. Adoption of this technology could help mitigate the adverse effects of poor agricultural waste management on the environment.
Identification of effective plant extracts against candidiasis: an in silico and in vitro approach
Authors: Bhairavi V. Anantha , Vidya S. L. , Sathishkumar R. 
Published: May 2023

Abstract
Background
Globally, millions of people suffer from repeated fungal infections affecting the skin, keratinized tissues, and mucosal membranes. Approximately 1.7 million cases result in death with an elevated incidence rate among immunocompromised people that may later result in severe infections. Among the causative agents, Candida albicans are the most prevalent fungi inducing subcutaneous to invasive candidiasis. Although they are commensals in human body alteration in gut or prolonged treatments results in candidiasis. Several virulence proteins of C. albicans are involved in infections and secreted aspartic proteases2 (SAP2) plays an important role among them by causing damage to the reconstituted human epithelium. In the present study, phytochemicals from Heliotropium indicum, Grona triflora, Ziziphus mauritiana, Atalantia racemosa, Coccinia grandis, Caryota urens, Aristolochia bracteolata, Evolvulus alsinoides, Pyrus communis and Commelina benghalensis were studied against SAP2 with the help of bioinformatic tools to understand their binding efficiency.

Results
The phytochemical structures were retrieved from PubChem database and the target protein structure was retrieved from PDB database with ID:3PVK. ADME profiling for phytochemicals was performed with Qikprop module, followed by docking with protein using Schrodinger software. Docking studies showed that Indicine-N-Oxide from H. indicum scored the significant glide score of − 5.54 kcal/mol. Finally, antifungal studies against C. albicans were conducted using several extracts of plants containing phytochemicals with considerable glide scores on docking studies. The Ethyl acetate leaf extract of H. indicum prominently inhibited the fungal growth when compared with the control.

Conclusion
Identification of effective therapeutic candidates for the treatment of fungal infection is facilitated by the potential of H. indicum to hinder fungal growth and the interaction of their phytocompounds with fungal targets paves a way for developing a novel drug.
Intrapericardial bronchogenic cyst extirpated through median sternotomy: a case report
Authors: Morita Koji , Yoshioka Hiromu , Tanaka Keisuke , Sugiura Junya , Yamamoto Ryota , Goto Yuki , Yamaki Koshi , Kato Wataru 
Published: May 2023

Background

Bronchogenic cyst sometimes occurs in the mediastinum and rarely in the intrapericardial space. When located in the intrapericardial space, the main vessels or the heart can be compressed. In addition, if it is difficult to deny malignancy or malignancy transformation potential using any modality, surgical resection should be performed.

Case presentation
The patient was a 21-year-old woman with persistent symptoms similar to a cold. Enhanced computed tomography confirmed a 51 × 36 × 35-mm intrapericardial cystic structure with partial calcification. The lesion was large enough to compress and interfere with the venous return of the superior vena cava. Thrombus formation was suspected upstream of the compression site. We performed utter extirpation through median sternotomy. A histopathological examination of the surgical specimen revealed a bronchogenic cyst. The postoperative course was uneventful, and she was discharged on postoperative day 9.

Conclusion
We experienced a case of total extirpation of an intrapericardial bronchogenic cyst complicated with compression of the superior vena cava. Long-term follow-up will be necessary.
Six-MicroRNA Prognostic Signature in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma
Authors: Worakitchanon Wittawin , Panvongsa Wittaya , Siripoon Teerada , Kitdumrongthum Sarunya , Wongpan Anongnat , Arsa Lalida , Trachu Narumol , Jinawath Natini , Chairoungdua Arthit , Ngamphaiboon Nuttapong 
Published: May 2023

PURPOSE MicroRNAs (miRNAs) have been evaluated as biomarkers in cancers. Therefore, we aimed to identify a prognostic miRNA signature from The Cancer Genome Atlas (TCGA) database and validate it in the Ramathibodi (RA) locally advanced head and neck squamous cell carcinoma (LA-HNSCC) cohort. METHODS The correlation between candidate miRNAs and the survival of patients with LA-HNSCC in TCGA database was analyzed. A prognostic miRNA signature model was generated that classified patients into high-risk and low-risk groups. This candidate miRNA signature was further validated in the independent RA cohort using droplet-digital polymerase chain reaction. RESULTS In TCGA database, we compared the expression of 277 miRNAs between 519 head and neck squamous cell carcinoma tissues and 44 normal tissues. The expression of hsa-miR-10b, hsa-miR-148b, hsa-miR-99a, hsa-miR-127, hsa-miR-370, and hsa-miR-500a was independently associated with overall survival (OS). Thus, we established the miRNA signature risk score from these six miRNAs and categorized patients into low-risk and high-risk groups. The median OS of TCGA patients was significantly shorter in the low-risk group than in the high-risk group ( P < .001). The six-miRNA signature was further validated in the RA cohort (N = 87). The median OS of the low-risk group was significantly shorter compared with the high-risk group ( P = .03). In multivariate analysis, the six-miRNA signature was an independent prognostic factor for OS in the RA cohort (HR, 1.958; 95% CI, 1.006 to 3.812; P = .048). CONCLUSION We identified a prognostic six-miRNA signature for patients with LA-HNSCC from TCGA cohort and validated it in our independent cohort. However, larger studies are warranted to confirm these results.
Transformer versus traditional natural language processing: how much data is enough for automated radiology report classification?
Authors: Yang Eric , Li Matthew D , Raghavan Shruti , Deng Francis , Lang Min , Succi Marc D , Huang Ambrose J , Kalpathy-Cramer Jayashree 
Published: May 2023

Objectives:
Current state-of-the-art natural language processing (NLP) techniques use transformer deep-learning architectures, which depend on large training datasets. We hypothesized that traditional NLP techniques may outperform transformers for smaller radiology report datasets.

Methods:
We compared the performance of BioBERT, a deep-learning-based transformer model pre-trained on biomedical text, and three traditional machine-learning models (gradient boosted tree, random forest, and logistic regression) on seven classification tasks given free-text radiology reports. Tasks included detection of appendicitis, diverticulitis, bowel obstruction, and enteritis/colitis on abdomen/pelvis CT reports, ischemic infarct on brain CT/MRI reports, and medial and lateral meniscus tears on knee MRI reports (7,204 total annotated reports). The performance of NLP models on held-out test sets was compared after training using the full training set, and 2.5%, 10%, 25%, 50%, and 75% random subsets of the training data.

Results:
In all tested classification tasks, BioBERT performed poorly at smaller training sample sizes compared to non-deep-learning NLP models. Specifically, BioBERT required training on approximately 1,000 reports to perform similarly or better than non-deep-learning models. At around 1,250 to 1,500 training samples, the testing performance for all models began to plateau, where additional training data yielded minimal performance gain.

Conclusions:
With larger sample sizes, transformer NLP models achieved superior performance in radiology report binary classification tasks. However, with smaller sizes (&lt;1000) and more imbalanced training data, traditional NLP techniques performed better.

Advances in knowledge:
Our benchmarks can help guide clinical NLP researchers in selecting machine-learning models according to their dataset characteristics.
Quality control method of steel structure construction based on digital twin technology
Authors: Liu Zhansheng , Wu Lejia , Liu Zisheng , Mo Yanchi 
Published: May 2023

Background: The quality of construction is crucial in evaluating steel structure. However, traditional quality control methods for steel structure construction have been criticized for their lack of intelligence, resulting in a heavier reliance on manual experience and post-construction inspections to address quality issues. This shortcoming makes quality management inefficient and labor-intensive. To address this issue, this paper proposes a smart quality control method based on digital twin technology. Methods: In this framework, data collection is used for subsequent quality control throughout the construction process. To improve pre-construction quality control, a mixed reality (MR) system is used to guide and train personnel. During the steel structure construction process, the Markov method is used to analyze and predict real-time data. Results: To test the effectiveness of the proposed method, ten sets of parallel tests were conducted to predict whether the bolt torque value was normal or not, resulting in an 80% accuracy rate. Conclusions: The proposed method for steel structure construction quality control was effectively certified, achieving active prevention and real-time control of quality problems and improving the overall intelligence level of quality control.
Mitral regurgitation quantification by cardiac magnetic resonance imaging (MRI) remains reproducible between software solutions
Authors: Grafton-Clarke Ciaran , Thornton George , Fidock Benjamin , Archer Gareth , Hose Rod , van der Geest Rob J. , Zhong Liang , Swift Andrew J. , Wild James M. , De Gárate Estefania , Bucciarelli-Ducci Chiara , Plein Sven , Treibel Thomas A. , Flather Marcus , Vassiliou Vassilios S. , Garg Pankaj 
Published: May 2023

Background: The reproducibility of mitral regurgitation (MR) quantification by cardiovascular magnetic resonance (CMR) imaging using different software solutions remains unclear. This research aimed to investigate the reproducibility of MR quantification between two software solutions: MASS (version 2019 EXP, LUMC, Netherlands) and CAAS (version 5.2, Pie Medical Imaging). Methods: CMR data of 35 patients with MR (12 primary MR, 13 mitral valve repair/replacement, and ten secondary MR) was used. Four methods of MR volume quantification were studied, including two 4D-flow CMR methods (MRMVAV and MRJet) and two non-4D-flow techniques (MRStandard and MRLVRV). We conducted within-software and inter-software correlation and agreement analyses. Results: All methods demonstrated significant correlation between the two software solutions: MRStandard (r=0.92, p<0.001), MRLVRV (r=0.95, p<0.001), MRJet (r=0.86, p<0.001), and MRMVAV (r=0.91, p<0.001). Between CAAS and MASS, MRJet and MRMVAV, compared to each of the four methods, were the only methods not to be associated with significant bias. Conclusions: We conclude that 4D-flow CMR methods demonstrate equivalent reproducibility to non-4D-flow methods but greater levels of agreement between software solutions.
THE TIGER IMAGE IN VIETNAMESE FOLK WOODEN PRINTS AS A REFLECTION OF RELIGIOUS FAITHS OF COUNTRY POPULATION
Authors: Legostaeva Albina S. 
Published: May 2023

The aim of research study is a revelation of the multi-layered image of the tiger in the spiritual and religious life of Vietnam, from local totem beliefs to world religions through explanations and illustrations of thematic wood prints of several centers.
Results. An analysis of the symbolic connotations associated with one of the key figures of the country’s zoomorphic pantheon makes it possible to evidentiate the ambivalence of its essence, a vivid embodiment of the contradictory features of which is interpreted in different ways in culture and art.
Scope of the results. The results of this study can heighten the interest in the culture of Vietnam as a whole, as well as to contribute to the representation expansion about popular folk prints as one of the most traditional and original types of Vietnamese fine art and can be applied in its in-depth analysis.
The relevance of the article is determined by the lack of research on this topic in the Russian-language literature.