bluuebunny/crossref_metadata_2025_split huggingface dataset:
Return to sport after meniscus RAMP lesion with anterior cruciate ligament injury management: A Systematic Reviews and protocol management
Authors: Srimongkolpi Surasak , Chernchujit Bancha , Ongkanchana Chavithorn , Apivatgaroon Adinun 
Published: March 2023

Abstract
The RAMP lesion is related to anterior cruciate ligament injury, and the management of the sport occupational patient is still lacking evidence and inconclusive on many issues, including return to sport timing, rehabilitation protocol, and whether to repair or leave the lesion (non-repair) during anterior cruciate ligament reconstruction. Several databases were used to search for results in PRISMA 2009 guideline was used to discuss the term "return to sport" in the RAMP lesion. Several studies were selected by the level of sport, type of sport injury, return to sport timing, level of return to sport, and post-operative rehabilitation. Totally, four studies were selected by inclusion criteria. In three studies, the follow-up timing was more than 24 months. The total of 215 patients were analyzed, and conclusions were reached. Result of the range of return to sport timing was 7 to 9 months until be able to return to same level (> 80%) both of repair RAMP lesion with ACLR except non-repair might be delayed. However, the most studies found that patient-reported outcomes did not differ significantly between the non-repair and repair RAMP sport activity groups. Most authors still recommend repair of the unstable and extended RAMP lesion with ACLR.
Hydrogen Bonds Structure and Electrostatic Interactions in a Non-Empirical Model of Ion Hydration
Authors: Dolgonosov Anatoly M. 
Published: March 2023

Abstract
A model of the ion hydration shell based on its topological, electrostatic, and hydrophilic properties at an atomic level has been developed. The energy of hydration layer is described taking into account the local dielectric permittivity, layer geometry in the cases of creation and destruction of hydrogen bonds, and the formation of a multilayer hydration shell. An expression for the ion hydration number is derived, which accounts for the ionic radius, charge, and the hydrogen bonding ability of the ion.
Pan-cancer analysis of co-inhibitory molecules reveals their potential prognostic and clinical values as biomarkers
Authors: Ren Xiaoyu , Geng Jiahui , Chen Yuling , Wang Xue , Zhou Lian , Shi Lei 
Published: March 2023

Abstract
The widespread use of immune checkpoint inhibitors (anti-CTLA4 or PD-1) has opened a new chapter in tumor immunotherapy by providing long-term survival for patients. Unfortunately, these agents are not universally available and only a small portion of patients respond to them. Therefore, there is an urgent need to develop novel therapeutic strategies targeting other co-inhibitory molecules, such as LAG3, TIM3, TIGIT, NRP1, VISTA. In addition, combination therapies including combined blockade and chemo-immunotherapy are promising topics in this field, such as the recent FDA approval of combination therapy targeting both LAG3 and PD-1. However, comprehensive information on the expression and prognostic value of co-inhibitory molecules, including co-inhibitory receptors and their ligands, in different cancers is not yet available. For this reason, we performed this analysis to assess the expression patterns and correlations of co-inhibitory molecules, and further evaluated their relationships with patient prognosis, tumor microenvironment and drug sensitivity. These co-inhibitory molecules have the potential to be prognostic biomarkers and drivers of individualized therapy for a wide range of cancers, as they are closely associated with these metrics.
Impact, Utility and Need for Teleorthodontics in Recent Times-A Systematic Review
Authors: Jha Sheetal , Singla Anshul , Sharma Shruti , Singh Rajeshwar , Nagar Ayushi 
Published: March 2023

Abstract
INTRODUCTION Teleorthodontics uses information technology to provide remote, global healthcare advice and treatment. This approach allows the exchange of patient-related information with healthcare providers and/ or related organizations using digital technology such as radiographs and healthcare-related consultations. This is in contrast to the traditional methods of healthcare management which rely on direct patient contact and communication. Furthermore, Teleorthodontics has been shown to be a valuable means of monitoring patients and facilitating patient-dentist communication, especially in the present COVID-19 pandemic that has challenged the existing global healthcare systems and all forms of healthcare policy.
OBJECTIVE To evaluate the impact, relevance and utility of teleorthodontics in today’s era.
METHODS In this systematic review, the articles search was performed on relevant studies collected through systematically developed and executed search strategies for the past 10 years in the following databases: PubMed, Google Scholar, Ebsco, Medline etc. The research was carried out by online and offline surfing and 10yrs database records.442 records were screened, out of which 8 articles were narrowed down to be included for the systematic review.
RESULTS There are 8 articles which suggested the impact and relevance of teleorthodontics in recent times.
CONCLUSION Based on 8 articles teleorthodontics is a go-to modality and an adjunct to traditional orthodontic diagnosis, consultation and treatment therapy.
Solution-Processed Single-Component Organic Photodetectors - Strong Quadrupole Moments in Molecules Enable the State-of-the-Art Performance
Authors: Park Song Yi , Labanti Chiara , Lee Tack Ho , Pacalaj Richard A. , Dong Yifan , Chin Yi-Chun , Luke Joel , Ryu Gihan , Minami Daiki , Yun Sungyoung , Park Jeong-Il , Fang Feifei , Park Kyung-Bae , Durrant James R. , Kim Ji-Seon 
Published: March 2023

Abstract
Donor-acceptor based bulk-heterojunctions (BHJ) are commonly used as the photoactive layer in organic photodetectors (OPDs) to utilize the energetic offset formed at the donor and acceptor interface for exciton dissociation. However, this strategy often complicates optimization procedures and raises the concerns over device reproducibility and stability. Herein, we demonstrate that solution-processed single-component organic semiconductors can operate as efficient OPDs. We use non-fullerene acceptors (NFAs) as the single-component photoactive layer, where the intermolecular charge transfer excitonic (CTE) states are formed within <1 ps, and efficient photocurrent generation is achieved via strong quenching of these CTE states by reverse bias. Y6 and IT-4F, prototypical NFAs, based OPDs show excellent OPD performances; low dark current density (~10-9 A cm-2), high responsivity (≥ 0.15 A W-1), high specific detectivity (> 1012 Jones) and fast photo-response time (< 10 μs), comparable to the state-of-the-art BHJ OPDs. We find these excellent single-component NFA OPD performances are strongly correlated with the high quadrupole moments of NFA molecules, which generate the energetic offset required for CTE state separation. Our work opens a new way to realize efficient OPD devices using single-component organic semiconductors via solution processing and provides the important molecular design rules required for single-component photoactive materials.
Different regrowth patterns after repeated clipping in two Mongolian pasture species
Authors: Hu Richa , Yoshihara Yu , Gantsetseg Batdelger , Kinugasa Toshihiko 
Published: March 2023

Abstract
We investigated changes in the regrowth patterns of two grass species on the Mongolian steppe, Agropyron cristatum and Stipa krylovii, in response to repeated clipping and used a growth analysis to identify the factors responsible for differences in their regrowth patterns. Plants grown in pots were clipped every 3 weeks, and leaf area, dry mass, and N and crude fiber contents were measured. Aboveground biomass recovered to the same level as that before clipping in both species even after 3 clipping–regrowth cycles, but the mechanisms behind their regrowth abilities differed. In A. cristatum, a decrease in biomass allocation to aboveground parts with repeated clipping was fully compensated by the positive effect derived from the increase in growth rate due to increased leaf area expansion associated with an increase in specific leaf area (SLA). In S. krylovii, a decrease in SLA reduced leaf area but at the same time increased N content per unit leaf area and consequently photosynthetic ability, leaving the growth rate unchanged. The values of growth parameters involved in regrowth after clipping changed with repeated clipping, and those changes differed between species. In particular, the difference in the response of SLA to repeated clipping contributed greatly to the difference in regrowth patterns. These results imply that changes in leaf morphology as plant strategies against grazing can contribute to plants’ regrowth patterns.
Research and application of the parallel computing method for the grid-based Xin'anjiang model
Authors: Liu Qian , Wan Dingsheng , Yu Yufeng , Zhang Yangming 
Published: March 2023

Abstract
The grid-based Xin'anjiang model (GXM) has been widely applied to flood forecasting. However, when the model warm-up period is long and the amount of input data is large, the computational efficiency of the GXM is obviously low. Therefore, a GXM parallel algorithm based on grid flow direction division is proposed from the perspective of spatial parallelism, which realizes the parallel computing of the GXM by extracting the parallel routing sequence of the watershed grids. To solve data skew, a Directed Acyclic Graph (DAG) scheduling algorithm based on dynamic priority is proposed for task scheduling. The proposed GXM parallel algorithm is verified in the Qianhe River watershed of Shaanxi Province and the Tunxi watershed of Anhui Province. The results show that the GXM parallel algorithm based on grid flow direction division has good flood forecasting accuracy and higher computational efficiency than the traditional serial computing method. In addition, the DAG scheduling algorithm can effectively improve the parallel efficiency of the GXM.
Multiple Natural Polymers in Drug and Gene Delivery Systems
Authors: Jiang Zhengfa , Song Zongmian , Cao Chen , Yan Miaoheng , Liu Zhendong , Cheng Xingbo , Wang Hongbo , Wang Qingnan , Liu Hongjian , Chen Songfeng 
Published: March 2023

Background:
Natural polymers are organic compounds produced by living organisms.
In nature, they exist in three main forms, including proteins, polysaccharides,
and nucleic acids. In recent years, with the continuous research on drug and gene delivery
systems, scholars have found that natural polymers have promising applications in
drug and gene delivery systems due to their excellent properties such as biocompatibility,
biodegradability, low immunogenicity, and easy modification. However, since the structure,
physicochemical properties, pharmacological properties and biological characteristics
of biopolymer molecules have not yet been entirely understood, further studies are required
before large-scale clinical application. This review focuses on recent advances in
the representative natural polymers such as proteins (albumin, collagen, elastin),
polysaccharides (chitosan, alginate, cellulose) and nucleic acids. We introduce the characteristics
of various types of natural polymers, and further outline the characterization
methods and delivery forms of these natural polymers. Finally, we discuss possible challenges
for natural polymers in subsequent experimental studies and clinical applications.
It provides an important strategy for the clinical application of natural polymers in drug
and gene delivery systems.
Advances in the Management of Heart Failure with Reduced Ejection Fraction;
The Role of SGLT2is, ARNI, Myotropes, Vericiguat, and Anti-inflammatory
Agents: A Mini-review
Authors: Vrachatis Dimitrios A. , Papathanasiou Konstantinos A. , Giotaki Sotiria G. , Raisakis Konstantinos , Kaoukis Andreas , Kossyvakis Charalampos , Theodorakis Andreas , Pediotidis Stauros , Avramides Dimitrios , Siasos Gerasimos , Deftereos Spyridon 
Published: March 2023

Abstract:
Heart failure with reduced ejection fraction (HFrEF) has been associated with poor prognosis, reduced quality of life, and increased healthcare expenditure. Despite tremendous advances in HFrEF management, reduced survival and a high rate of hospitalization remain unsolved issues. Furthermore, HFrEF morbidity and economic burden are estimated to increase in the following years; hence, new therapies are constantly emerging. In the last few years, a series of landmark clinical trials have expanded our therapeutic armamentarium with a ground-breaking change in HFrEF-related outcomes. Sodium-glucose co-transporter 2 inhibitors (mainly dapagliflozin and empagliflozin) have already revolutionized the management of HFrEF patients via a significant reduction in cardiovascular mortality and heart failure hospitalizations. Furthermore, vericiguat and omecamtiv mecarbil have emerged as promising and novel disease-modifying therapies. The former restores the impaired cyclic guanosine monophosphate pathway, and the latter stimulates cardiac myosin without marked arrhythmogenesis. Both vericiguat and omecamtiv mecarbil have been shown to reduce heart failure admissions. Sacubitril/valsartan is an established and effective therapy in HFrEF patients and should be considered as a replacement for angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II receptor blockers (ARBs). Lastly, inflammasome activity is implicated in HFrEF pathophysiology, and the role of anti-inflammatory agents in HFrEF trajectories is readily scrutinized, yet available therapies are ineffective. This mini-review summarizes the major and most recent studies in this field, thus covering the current advances in HFrEF therapeutics.
Two Sustained Release Membranes Used in Formulating Low Strength
Testosterone Reservoir Transdermal Patches
Authors: Vashishth Ria , Chuong Monica C. , Duarte Juan Chang , Gharat Yadnya , Kerr Stephen G. 
Published: March 2023

Introduction:
Several Testosterone Replacement Therapies exist for hypogonadism, but an
in-depth analysis of these products reveals a high dosing frequency and a high drug loading, up to 120
mg for a potent drug like Testosterone. This may lead to patient non-compliance and toxicity problems
if used improperly. Androderm® is the only 24-hour marketed transdermal patch. Testopel pellets are
another extended-release product given subcutaneously every 3-6 months. But it requires surgical implantation
and is associated with severe adverse effects. For this reason, the development of other extended-
release testosterone products is needed. The study aims at using different excipients for the exploration
of sustained-release patches.

Methods:
Reservoir formulations were prepared using Carbomer 941 and HPMC K100M as the sustained-
release polymers plus CoTran™ 9702 and CoTran™ 9712 as the release membranes. The formulated
patches were subjected to in vitro dissolution for 24 h. The amount of drug release at each time
point was determined using the developed HPLC assay. FDA Similarity Factor, f2, t-test, and ANOVA
were applied to all nine-point collected samples.

Results:
CoTran™ 9712 membrane was found to be a better candidate than CoTran™ 9702. The
in vitro release profiles of the four formulations were compared (Carbomer vs. HPMC, and CoTran™
9702 vs. CoTran™ 9712).

Conclusion:
CoTran™ 9702 releases testosterone significantly lower. Carbomer and CoTran™ 9712
were the best formulation among all with the highest drug release of 2.16 ± 0.36 mg.
LINC00461 Knockdown Enhances the Effect of Ixazomib in Multiple Myeloma Cells
Authors: Deng Mingyang , Yuan Huan , Peng Hongling , Liu Sufang , Xiao Xiang , Wang Zhihua , Zhang Guangsen , Xiao Han 
Published: March 2023

Background:LINC00461 has been implicated to be involved in several types of cancer while its roles in multiple myeloma remain unclear. Our study aims to investigate the roles of LINC00461 in multiple myeloma and explore its effects on ixazomib therapy.Methods:LINC00461 and small nuclear ribonucleoprotein polypeptide (SNRP) B2 knockdown stable cell lines were constructed. Cell viability assays including MTT, cell number counting, and colony formation were performed. RNA-pull down and immunoblotting assays were conducted to determine the intramolecular interactions. qRT-PCR and western blotting were conducted to determine the levels of target genes. Kaplan-Meier analysis was used to evaluate overall survival rates.Results:Knockdown of LINC00461 or SNRPB2 enhanced ixazomib's cytotoxicity, as well as affected its regulatory effects on cell apoptosis and cell cycle distribution. Further results showed that LINC00461 knockdown reduced the expression levels of SNRPB2 by their interactions. Additionally, a positive correlation between LINC00461 and SNRPB2 was found in patients with multiple myeloma. Low expression of SNRPB2 was associated with a high survival rate in patients with multiple myeloma.Conclusion:Knockdown of LINC00461 enhanced the therapeutic effects of ixazomib against multiple myeloma in part by the regulation of SNRPB2
Emerging Promise of Therapeutic Approaches Targeting Mitochondria in
Neurodegenerative Disorders
Authors: Rahman Md. Mominur , Tumpa Mst. Afroza Alam , Rahaman Md. Saidur , Islam Fahadul , Sutradhar Popy Rani , Ahmed Muniruddin , Alghamdi Badrah S. , Hafeez Abdul , Alexiou Athanasios , Perveen Asma , Ashraf Ghulam Md. 
Published: March 2023

Abstract:
Mitochondria are critical for homeostasis and metabolism in all cellular eukaryotes. Brain
mitochondria are the primary source of fuel that supports many brain functions, including intracellular
energy supply, cellular calcium regulation, regulation of limited cellular oxidative capacity, and control
of cell death. Much evidence suggests that mitochondria play a central role in neurodegenerative
disorders (NDDs) such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic
lateral sclerosis. Ongoing studies of NDDs have revealed that mitochondrial pathology is
mainly found in inherited or irregular NDDs and is thought to be associated with the pathophysiological
cycle of these disorders. Typical mitochondrial disturbances in NDDs include increased free radical
production, decreased ATP synthesis, alterations in mitochondrial permeability, and mitochondrial
DNA damage. The main objective of this review is to highlight the basic mitochondrial problems that
occur in NDDs and discuss the use mitochondrial drugs, especially mitochondrial antioxidants, mitochondrial
permeability transition blockade, and mitochondrial gene therapy, for the treatment and control
of NDDs.
Monoclonal CCR5 Antibody: A Promising Therapy for HIV
Authors: Lai Yu , Zhao Li 
Published: March 2023

Abstract:
HIV is one of the world's most devastating viral infections and has claimed tens of millions
of lives worldwide since it was first identified in the 1980s. There is no cure for HIV infection. However,
with tremendous progress in HIV diagnosis, prevention, and treatment, HIV has become a manageable
chronic health disease. CCR5 is an important coreceptor used by HIV to infect target cells,
and genetic deficiency of the chemokine receptor CCR5 confers a significant degree of protection
against HIV infection. In addition, since CCR5 deficiency does not appear to cause any adverse
health effects, targeting this coreceptor is a promising strategy for the treatment and prevention of
HIV. Monoclonal antibodies are frequently used as therapeutics for many diseases and therefore are
being used as a potential therapy for HIV-1 infection. This review reports on CCR5 antibody research
in detail and describes the role and advantages of CCR5 antibodies in HIV prevention or treatment,
introduces several main CCR5 antibodies, and discusses the future strategy of antibody-conjugated
nanoparticles including the potential challenges. CCR5 antibodies may be a novel therapy for treating
HIV infection effectively and could overcome the limitations of the currently available options.
Saraca asoca: From Traditional Herb to Modern Drug as a Cure for Various
Diseases
Authors: Fathima Faiza , Parveen Rabea , Khan Mohammad Aasif , Malik Zoya , Mustafa Saad , Massey Sheersh , Ahmad Sayeed , Husain Syed Akhtar 
Published: March 2023

Background:
Saraca asoca (Ashoka, family; Caesalpiniaceae) is an indigenous sacred tree,
native to India. It has been used in various traditional medicinal systems and is one such plant that is
highly therapeutic but its use in disease management is underrated in today’s era and has lost its importance.

Objective:
This narrative review is written to provide the information on medicinal importance of S.
asoca and the significance of S. asoca in various traditional medicinal systems.

Methods:
Different databases were searched to gather information. Research articles, abstracts, and
reviews are included in this review.

Results:
Saraca asoca is known for its unique pharmacological role in treating various uterine complications,
menstrual disorders, and bacterial infections, bleeding hemorrhoids, urinary and dermatological
problems. The stem bark of the tree is the principal constituent for treating menorrhagia and
genito-urinary disorders. The stem bark, leaves, and seeds of S. asoca are known to contain flavonoids,
tannins, alkaloids, glycosides, polyphenolics, fatty acids, and saponins. The reported major phytoconstituents
responsible for its therapeutic uses are epicatechin, procyanidin B2, lyoniside, nudiposide,
catechin, leucocyanidin, and leucopelargonidin. Various pharmacological activities of this plant
are discussed in this review.

Conclusion:
It has been proved that Saraca asoca possesses several pharmacological properties and is
useful in treating various diseases. More studies on quality control, standardization, and clinical trials
on S. asoca should be performed, so that this plant could be utilized as an effective anti-cancer drug
which could be a promising source for the herbal and pharmaceutical industry.
Sulfonic Acid Functionalized Precipitated Silica as Efficient Solid Acid
Catalyst for Acetylation Reactions
Authors: Chaskar Manohar G. , Ghosh Anirban , Lolage Mayura 
Published: March 2023

Introduction:
Precipitated Silica has very high commercial significance in terms of ease of preparation, market volume, cost benefits and a wide range of industrial applications. The surface silanol groups of Precipitated Silica can be modified with reactive organic functional groups to achieve desired properties for specific applications, including catalysis.

Objective::
The objective of this study is to demonstrate sulfonic acid functionalized Precipitated Silica as
a true heterogeneous catalyst in acetylation reaction, where the catalytic activity and desired product selectivity
is a magnitude higher than industrial solid acid zeolite catalysts as well as similar catalysts reported
in literature.

Methods:
A novel and cost-effective method for the functionalization of Precipitated Silica with sulfonic acid (–SO3H) is reported, where the silica nanoparticles are first functionalized in situ with a tetrasulfide organosilane, followed by oxidation of the tetrasulfide moiety to –SO3H groups, which are grafted to the surface silanol groups through covalent linkage.

Results:
CHNS analyses and XPS prove successful functionalization of –SO3H group onto the nano silica surface. The resultant material acts as a solid acid catalyst and shows exceptional activity in the acetylation of benzyl alcohol and >99% selectivity towards the desired product benzyl acetate. The resultant material can also be recycled and reused several times.

Conclusion:
The following factors make sulfonic acid functionalized Precipitated Silica a new generation of solid acid catalyst; (i) higher atom economy, (ii) recyclability and reusability, and (iii) significant cost benefits with respect to industrial catalysts.