bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Sonazoid enhanced ultrasound assistant laparoscopic radiofrequency ablation in treating liver malignancy—A single‐center retrospective cohort study
Authors: Xu Jingyong , Liu Yuan , Wu Mingxiao , Song Jinghai , Li Chen 
Published: March 2023

AbstractAimTo evaluate the role of Sonazoid enhanced ultrasound assistant laparoscopic radiofrequency ablation in treating liver malignancy.MethodsConsecutive patients are recruited. Rates of complication and postoperative length of stay are compared between the study and control groups. Progression‐free survival (PFS) of colorectal liver metastasis (CRLM) after ablation are compared. Complete ablation rates are compared and optimal tumor size is calculated by ROC curve analysis. Risk factors of incomplete ablation are determined by logistic regression analysis.ResultsTotally 73 patients with 153 lesions were included. No significant differences in the rate of complication were found between the study and control groups. PFS of CRLM in laparoscopic, intraoperative CEUS, and laparoscopic CEUS groups are all longer than their control groups. Complete ablation rates of laparoscopic, intraoperative CEUS, and laparoscopic CEUS groups are all higher than in their control groups with statistical significance. A tumor size of 2.15 cm is determined to be the optimal cut‐off with the area under the ROC curve of 0.854, 95% CI (0.764, 0.944), p = 0.001. In logistic regression analysis, tumor size [OR 20.425, 95% CI (3.136, 133.045), p = 0.002] and location of segments VII and VIII [OR 9.433, 95% CI (1.364, 65.223), p = 0.023] are calculated to be the risk factors of incomplete ablation, meanwhile, intraoperative CEUS shows to be a protective factor in univariate analysis [OR 0.110, 95% CI (0.013, 0.915), p = 0.041].ConclusionSonazoid‐enhanced ultrasound assistant laparoscopic radiofrequency ablation is safe and effective to treat liver malignancy. We should pay attention to the ablation planning of larger tumors and tumors in special locations.
Advances in immune checkpoint inhibitors therapy for small cell lung cancer
Authors: Li Longhui , Liang Yangyueying , Yu Minghui , Zhao Lu , Mei Qingyun , Yu Yongchao , Wang Na , Zhang Dou , Wang Ziwei , Jia Yingjie , Kong Fanming 
Published: March 2023

AbstractBackgroundAs one of the most aggressive neuroendocrine tumors, small cell lung cancer (SCLC) has the most disappointing prognosis of all lung cancers. Although SCLC responds well to initial chemotherapy, the majority of patients experience disease recurrence within one year, and patient survival is poor. It is still necessary to explore the application of ICIs in SCLC since the beginning of the road to immunotherapy, which broke the 30‐year treatment deadlock of SCLC.MethodsWe searched PubMed, Web of Science, and Embase with search terms such as "SCLC", "ES‐SCLC", "ICIs", and "ICBs", and categorized and summarized the relevant literature obtained, and we compiled the latest progress about the application of ICIs in SCLC.ResultsWe listed 14 clinical trials on ICIs, including 8 clinical trials on first‐line SCLC treatment, 2 clinical trials on second‐line SCLC treatment, 3 clinical trials on third‐line SCLC treatment, and 1 clinical trial on SCLC maintenance treatment.ConclusionICIs in combination with chemotherapy can improve OS in SCLC patients, but the extent to which SCLC patients can benefit from ICIs is limited, and ICIs' combination treatment strategies still need to be continuously explored.
Evaluation of the efficacy of chemotherapy for tubular carcinoma of the breast: A Surveillance, Epidemiology, and End Results cohort study
Authors: Zhao Yuting , Chai Na , Li Shouyu , Yan Lutong , Zhou Can , He Jianjun , Zhang Huimin 
Published: March 2023

AbstractBackgroundThe use of systematic treatment for tubular carcinoma (TC) of the breast remained controversial. This study aimed to explore the efficacy of chemotherapy on TC to develop individualized treatment strategies.MethodsUsing the Surveillance, Epidemiology, and End Results (SEER) database, 6486 eligible cases with TC and 309,304 with invasive ductal carcinoma (IDC) were collected. Breast cancer‐specific survival (BCSS) was assessed through multivariable Cox analyses and Kaplan–Meier analyses. Differences between groups were balanced using propensity score matching (PSM) and inverse probability of treatment weighting (IPTW).ResultsCompared with IDC patients, TC patients had a more favorable long‐term BCSS after PSM (hazard ratio = 0.62, p = 0.004) and IPTW (hazard ratio = 0.61, p < 0.001). Chemotherapy was an unfavorable predictor of BCSS for TC (hazard ratio = 3.20, p < 0.001). After stratifying by hormone receptor (HR) and lymph node (LN) status, chemotherapy was correlated with worse BCSS in the HR+/LN− subgroup (hazard ratio = 6.95, p = 0.001) but showed no impact on BCSS in the HR+/LN+ (hazard ratio = 0.75, p = 0.780) and HR−/LN− (hazard ratio = 7.87, p = 0.150) subgroups.ConclusionsTubular carcinoma is a low‐grade malignant tumor with favorable clinicopathological features and excellent long‐term survival. Adjuvant chemotherapy was not recommended for TC regardless of HR and LN status, while the therapy regimens should be carefully individualized.
How do counselling trainees describe group process and does this change over time?
Authors: Murphy Rick , Schofield Matt 
Published: March 2023

AbstractPersonal development groups or “group processes” are used in most counselling and psychotherapy trainings, but little is understood about how trainees change in their experience and descriptions of them over time. This study collected qualitative surveys (N = 70) from two groups of master's students (N = 35), at the mid‐ and end point of their first year of counselling training, to find out whether their descriptions of group process changed. We used content analysis to study the most common words and phrases used by trainee counsellors to describe group process and to monitor how positive, neutral and negative their descriptions were over time. We found a significant difference in the vocabulary and the ratio of positive to negative descriptions of group process at the midpoint of term, depending on the group the trainees were assigned to, with a levelling out of vocabulary words and positive and negative descriptions over time, converging towards a 70%–80% positive point at the end of term. Our results indicate that process groups need time to develop trainees above a positive threshold, by balancing group bonding against an ability to challenge and learn from difference, because individuals and groups start at different points in relation to their readiness and capacity for personal development. Further research should explore facilitation and trainee variables, as well as the impact of process groups on students' well‐being, because, while most of our students positively described the process, an important minority of students described negative experiences that were unresolved at the end of the study.
An Inclusive Review on the Assessment of Different Techniques for Natural Gas Liquid Recovery
Authors: Usman Muhammad , Pervaiz Erum 
Published: March 2023

AbstractA comprehensive review is presented on the natural gas liquid (NGL) recovery process with emphasis on process description, energy requirements, NGL production, operating cost, and propane recovery. The industry standard single‐stage (ISS), recycle split vapor (RSV), cold residue reflux (CRR), and gas subcooled process (GSP) technologies focus on the improvement in the rectifying section of the demethanizer column, while the enhanced NGL recovery process (IPSI) focuses on the stripping section of the column. The fluor process consists of an absorber, a scrub column, and heavy hydrocarbon (HHC) separator, which form the integrated process of liquification and NGL separation. For rich feed, the economic performance, payback, and total annualized cost (TAC) of the IPSI process were lower than the other processes. For lean feed, the results of the scrub column scheme demonstrate the finest economic performance.
Capillary Pressure Determination Using Thermodynamic Desorption Isotherms and Porosity Measurements
Authors: Shigidi Ihab , Chemkhi Saber 
Published: March 2023

AbstractCharacterization of fluid flow in porous media depends on the capillary pressure. Experimental investigations on the capillary pressure are complicated and require advanced monitoring technologies. The objective of this study is to determine the capillary pressure by employing desorption isotherms measurements and using the Kelvin equation. The desorption isotherms curves were determined by the gravimetric method. The capillary pressure is presented as a function of the material's level of saturation, which is linked to the material moisture content and total porosity. Investigations were conducted over three types of clays to give classical behavior of their capillary pressure curves. The obtained results were compared with those of the literature concluding the reliability of the employed method to achieve good capillary pressure curve predictions.
Investigation of the Cold Flow Field in a Flow Reversal Reactor through Computational Fluid Dynamics Models
Authors: Liang Wenjun , Sun Yujie , Ju Haolin , Ren Sida , Li Xiang , Liu Jia 
Published: March 2023

AbstractTo optimize the flow field in a tubular reactor, new flow deflectors were added by using flow reversal technology. Two optimization structures, namely asterisk plate and composite plate, were designed. Numerical simulation was combined with physical experiments to verify the effectiveness of the flow field optimization. The results showed that the flow field uniformity of the reactor could be greatly improved by single plate and double plate. The uniformity index of the velocity in the axial section is greater than 0.95 within 15 cm, and the physical simulation results conform to the overall trend of the numerical simulation. However, the length of the optimized area of the single plate is about 5 cm shorter than that of the double plate, and it has better stability in the physical model.
Trapping of a Transient Base‐Stabilised Alumylene and Alumylene‐Type Reactivity of a Self‐Stabilising Dialumene towards Organic Azides
Authors: Dhara Debabrata , Jayaraman Arumugam , Härterich Marcel , Arrowsmith Merle , Jürgensen Malte , Michel Maximilian , Braunschweig Holger 
Published: March 2023

AbstractThe reduction of a carbene‐coordinated, sterically encumbered terphenyl‐substituted aluminium diiodide, (LRAlI2), yielded a “masked” dialumene (LRAl=AlRL), self‐stabilised through [2+2] cycloaddition with a peripheral aromatic group. During the course of the reaction, a carbene‐stabilised arylalumylene (LRAl:) was generated in situ, which was trapped using an alkyne, generating an aluminacyclopropene or a C−H activated product thereof, depending on the steric bulk of the alkyne. The masked dialumene also underwent intramolecular cycloreversion and dissociation into alumylene fragments, which reacted with various organic azides to yield monomeric or dimeric iminoalanes depending on the sterics of the azide substituent. The thermodynamics of monomeric and dimeric iminoalane formation were probed by theoretical calculations.
Exposure–response Modeling From the CLARITY Trial of Pimavanserin for Adjunctive Treatment of Major Depressive Disorder
Authors: Darwish Mona , Dirks Bryan , Passarell Julie , Jaworowicz David , Bihorel Sebastien , Howell Becky , Owen Joel , DeKarske Daryl , Stankovic Srdjan 
Published: March 2023

AbstractIn the 10‐week, phase 2 CLARITY study of patients with major depressive disorder, adjunctive therapy to antidepressants with pimavanserin 34 mg once daily statistically significantly improved the Hamilton Depression Rating Scale (HAMD‐17) total score (primary endpoint) and Sheehan Disability Scale (SDS) score (secondary endpoint) versus placebo. This analysis characterized the exposure–response (E–R) relationships of pimavanserin in this CLARITY patient population. Exposure measures were estimated for each patient based on population‐pharmacokinetic empirical Bayesian estimates. E–R models were developed to describe exposure–efficacy (HAMD‐17, SDS, and Clinical Global Impression‐Improvement [CGI‐I] scale) and exposure–safety relationships (Karolinska Sleepiness Scale [KSS], Massachusetts General Hospital Sexual Functioning Inventory [MGH‐SFI], and adverse events [AEs] of headache, sedation, and somnolence) relationships. For the primary efficacy endpoint (HAMD‐17 scores), a sigmoid maximum‐effect model described the time course of response, and a linear function of pimavanserin exposure was statistically significant. HAMD‐17 scores decreased steadily over time following placebo and pimavanserin treatment; separation from placebo increased as peak pimavanserin plasma concentration (Cmax) increased. At median pimavanserin Cmax (34‐mg dose), the reduction from baseline in HAMD‐17 scores was −11.1 and −13.5 at weeks 5 and 10, respectively. Relative to placebo, the model predicted comparable reductions in HAMD‐17 scores at weeks 5 and 10. Similar improvements in favor of pimavanserin were detected with SDS, CGI‐I, MGH‐SFI, and KSS scores. No E–R relationship was found for AEs. E–R modeling predicted a relationship between higher pimavanserin exposure and improvement in HAMD‐17 score and improvement across multiple secondary efficacy endpoints.
Teff: Food for the Future
Authors: Lamichhane Ritika , Walsh Olga S. 
Published: March 2023

AbstractTeff (Eragrostis tef) is a native Ethiopian grain crop that is gaining popularity in the United States as a nutritious grain and a high quality forage crop. It is a reliable low‐risk crop that is relatively resistant to biotic and abiotic stresses and can be grown under moisture stress or waterlogged conditions. While it has a lot of potential, more research and education on teff is needed, particularly in the area of breeding and in the cropʼs nutrient and water requirements. Earn 0.5 CEUs in Crop Management by reading this article and taking the quiz at https://web.sciencesocieties.org/Learning‐Center/Courses.
Regenerative potential and limitations in a zebrafish model of hyperglycemia‐induced nerve degeneration
Authors: Sargent Sheridan , Brennan Anna , Clark Jessica Kennett 
Published: March 2023

AbstractBackgroundPrevious work from our lab has described a model of motor nerve degeneration in hyperglycemic zebrafish larvae which resembles mammalian models of diabetic peripheral neuropathy (DPN). Here, we optimized the hyperglycemic‐induction protocol, characterized deficits in nerve structure and behavioral function, and then examined the regenerative potential following recovery from the hyperglycemic state.ResultsIn agreement with our previous work, hyperglycemia induced motor nerve degeneration and behavioral deficits. However, the optimized protocol initiated disruption of tight junctions within the blood‐nerve barrier, a phenotype apparent in mammalian models of DPN. Following a 10‐day recovery period, regeneration of motor nerve components was apparent, but behavioral deficits persisted. We next examined the effect of hyperglycemia on the musculoskeletal system and found subtle deficits in muscle that resolved following recovery, and robust deficits in the skeletal system which persisted following recovery.ConclusionHere we optimized our previous model of hyperglycemia‐induced motor nerve degeneration to more closely align with that observed in mammalian models and then characterized the regenerative potential following recovery from hyperglycemia. Notably, we observed striking impairments to skeletal development, which underscores the global impact hyperglycemia has across systems, and provides a framework for elucidating molecular mechanisms responsible for regenerative events moving forward.
Discordant growth of nasal cartilage and bone contributes to phenotypic variability of the skull in a mouse model
Authors: Book Shae A. , Moore Alyssa C. , Tourigny Madeline S. G. , Barr Kevin , Willmore Katherine E. 
Published: March 2023

AbstractBackgroundWe previously determined a nonlinear relationship between connexin 43 (Cx43) function and craniofacial phenotypic variation in the mutant mouse model G60S/+, and that this variation was driven by nasal bone deviation. While nonlinearities in the genotype‐phenotype map appear to be common, few studies have looked at the developmental processes that underlie this nonlinearity. Here, we investigated the potential tissue‐level developmental determinants of the variation in nasal bone phenotype in G60S/+ mice through postnatal development.ResultsThe deviated nasal bone phenotype arises by postnatal day 21 and becomes more severe by 3 months in G60S/+ mice. Measures of nasal bone remodeling including the number of osteoclasts, mineralizing surface, mineral apposition rate, and bone formation rate are significantly greater in G60S/+ mice compared to wild‐type mice at 2 months, but these differences do not correspond with nasal bone deviation. The degree of nasal bone deviation does significantly and negatively correlate with the ratio between nasal bone and cartilaginous nasal septum length.ConclusionsOur findings indicate that the mean phenotypic changes observed between G60S/+ and wild‐type mice are due to reduced bone growth, but the increased phenotypic variation found within mutant mice is due to discordant growth between nasal cartilage and bone.
Tensorial independent component analysis reveals social and reward networks associated with major depressive disorder
Authors: Dennison Jeff B. , Tepfer Lindsey J. , Smith David V. 
Published: March 2023

AbstractMajor depressive disorder (MDD) has been associated with changes in functional brain connectivity. Yet, typical analyses of functional connectivity, such as spatial independent components analysis (ICA) for resting‐state data, often ignore sources of between‐subject variability, which may be crucial for identifying functional connectivity patterns associated with MDD. Typically, methods like spatial ICA will identify a single component to represent a network like the default mode network (DMN), even if groups within the data show differential DMN coactivation. To address this gap, this project applies a tensorial extension of ICA (tensorial ICA)—which explicitly incorporates between‐subject variability—to identify functionally connected networks using functional MRI data from the Human Connectome Project (HCP). Data from the HCP included individuals with a diagnosis of MDD, a family history of MDD, and healthy controls performing a gambling and social cognition task. Based on evidence associating MDD with blunted neural activation to rewards and social stimuli, we predicted that tensorial ICA would identify networks associated with reduced spatiotemporal coherence and blunted social and reward‐based network activity in MDD. Across both tasks, tensorial ICA identified three networks showing decreased coherence in MDD. All three networks included ventromedial prefrontal cortex, striatum, and cerebellum and showed different activation across the conditions of their respective tasks. However, MDD was only associated with differences in task‐based activation in one network from the social task. Additionally, these results suggest that tensorial ICA could be a valuable tool for understanding clinical differences in relation to network activation and connectivity.
Comparison of a full and partial choice set design in a labeled discrete choice experiment
Authors: Thai Thao , Bliemer Michiel , Chen Gang , Spinks Jean , de New Sonja , Lancsar Emily 
Published: March 2023

AbstractLabeled discrete choice experiments (DCEs) commonly present all alternatives using a full choice set design (FCSD), which could impose a high cognitive burden on respondents. In the setting of employment preferences, this study explored if a partial choice set design (PCSD) reduced cognitive burden whilst maintaining convergent validity compared with a FCSD. Respondents' preferences between the two designs were investigated. In the experimental design, labeled utility functions were rewritten into a single generic utility function using label dummy variables to generate an efficient PCSD with 3 alternatives shown in each choice task (out of 6). The DCE was embedded in a nationwide survey of 790 Australian pharmacy degree holders where respondents were presented with both a block of FCSD and PCSD tasks in random order. The PCSD's impact on error variances was investigated using a heteroscedastic conditional logit model. The convergent validity of PCSD was based on the equality of willingness‐to‐forgo‐expected‐salary estimates from Willingness‐to‐pay‐space mixed logit models. A nested logit model was used combined with respondents' qualitative responses to understand respondents' design preferences. We show a promising future use of PCSD by providing evidence that PCSD can reduce cognitive burden while satisfying convergent validity compared to FCSD.
Type H blood vessels in coupling angiogenesis‐osteogenesis and its application in bone tissue engineering
Authors: Xu Zhengyi , Kusumbe Anjali P. , Cai He , Wan Qianbing , Chen Junyu 
Published: March 2023

AbstractOne specific capillary subtype, termed type H vessel, has been found with unique functional characteristics in coupling angiogenesis with osteogenesis. Researchers have fabricated a variety of tissue engineering scaffolds to enhance bone healing and regeneration through the accumulation of type H vessels. However, only a limited number of reviews discussed the tissue engineering strategies for type H vessel regulation. The object of this review is to summary the current utilizes of bone tissue engineering to regulate type H vessels through various signal pathways including Notch, PDGF‐BB, Slit3, HIF‐1α, and VEGF signaling. Moreover, we give an insightful overview of recent research progress about the morphological, spatial and age‐dependent characteristics of type H blood vessels. Their unique role in tying angiogenesis and osteogenesis together via blood flow, cellular microenvironment, immune system and nervous system are also summarized. This review article would provide an insight into the combination of tissue engineering scaffolds with type H vessels and identify future perspectives for vasculized tissue engineering research.
Allantoin induces pruritus by activating MrgprD in chronic kidney disease
Authors: Yang Yan , Sun Yulin , Zhu Chan , Shen Xinyu , Sun Jianmei , Jing Tao , Jun Shi , Wang Changming , Yu Guang , Dong Xinzhong , Sheng Meixiao , Tang Zongxiang 
Published: March 2023

AbstractChronic kidney disease (CKD) is a disease with decreased, irreversible renal function. Pruritus is the most common skin symptom in patients with CKD, especially in end‐stage renal disease. The underlying molecular and neural mechanism of CKD‐associated pruritus (CKD‐aP) remains obscure. Our data show that the level of allantoin increases in the serum of CKD‐aP and CKD model mice. Allantoin could induce scratching behavior in mice and active DRG neurons. The calcium influx and action potential reduced significantly in DRG neurons of MrgprD KO or TRPV1 KO mice. U73122, an antagonist of phospholipase C, could also block calcium influx in DRG neurons induced by allantoin. Thus, our results concluded that allantoin plays an important role in CKD‐aP, mediated by MrgprD and TrpV1, in CKD patients.