bluuebunny/crossref_metadata_2025_split huggingface dataset:
RELATIVISMO EPISTÊMICO SOBRE A CIÊNCIA
Authors: Rios Maurício Cavalcante 
Published: March 2023

Neste trabalho, temos como objetivo investigar o desacordo entre Filosofia e Sociologia do Conhecimento Científico em torno da noção do relativismo. Esse desacordo orbita ao redor da Tese da Igual Validade e da Tese do Construcionismo Forte, compreendendo que Epistemologia e Filosofia da Ciência refletem imagens sociais de suas épocas. David Bloor (2011) declara que é hábito dos filósofos antirrelativistas confundir a Tese da Igual Validade e a Tese do Construcionismo Social Forte com o relativismo da Sociologia do Conhecimento Científico. Justificando que esse debate situa-se entre Epistemologia, Filosofia da Ciência e Sociologia do Conhecimento Científico, uma vez que há diferentes atribuições sobre a formação de crenças para o conhecimento científico, o problema desse artigo é o seguinte: se os argumentos relativistas de David Bloor (2011) criticam posturas epistemológicas antirrelativistas, então o relativismo do Programa Forte endossa o relativismo epistêmico ? Para respondermos esse problema, partimos da seguinte hipótese: se as Teses do Programa Forte se dirigem a diversos modos de se conhecer, então seu relativismo é epistêmico.
Palavras-chaves: Epistemologia, Filosofia da Ciência, Sociologia do Conhecimento Científico, Relativismo, Relativismo Epistêmico.
Determination of intramedullary nail based on centerline adaptive registration
Authors: Liu Xiaolong , Li Jin , Luan Kuan 
Published: March 2023

Objective: Internal fixation with intramedullary nails is a gold standard for the treatment of femoral shaft fractures. However, both the mismatch between intramedullary nails and the medullary cavity and inaccurate positioning of entry points will lead to deformation of intramedullary nails after implantation. The study aimed to determine a suitable intramedullary nail with an optimal entry point for a specific patient based on centerline adaptive registration.Method: A homotopic thinning algorithm is employed to extract centerlines of the femoral medullary cavity and the intramedullary nail. The two centerlines are registered to obtain a transformation. The medullary cavity and the intramedullary nail are registered based on the transformation. Next, a plane projection method is employed to calculate the surface points of the intramedullary nail laid outside the medullary cavity. According to the distribution of compenetration points, an iterative adaptive registration strategy is designed to decide an optimal position of the intramedullary nail in medullary cavity. The isthmus centerline is extended to the femur surface, where the entry point of the intramedullary nail is located. The suitability of an intramedullary nail for a specific patient was calculated by measuring the geometric quantities reflecting the interference between the femur and nail, and the suitability values of all nails are compared and the most suitable one is determined.Results: The growth experiment indicated that the bone to nail alignment is indeed affected by the extension of the isthmus centerline, including the extension direction and velocity. The geometrical experiment showed that this method could find the best registration position of intramedullary nails and select the optimal intramedullary nail for a specific patient. In the model experiments, the determined intramedullary nail could be successfully placed into the medullary cavity through the optimal entry point. A pre-screening tool to determine nails which can be successfully used has been given. In addition, the distal hole was accurately located within 14.28 s.Conclusion: These results suggest that the proposed method can select a suitable intramedullary nail with an optimal entry point. The position of the intramedullary nail can be determined in the medullary cavity, while deformation is avoided. The proposed method can determine the largest diameter intramedullary nail with as little damage to the intramedullary tissue as possible. The proposed method provides preparation aid for internal fixation with intramedullary nails guided by navigation systems or extracorporeal aimers.
ncRNA-mediated upregulation of FAM83A is associated with poor prognosis and immune infiltration in pancreatic cancer
Authors: Zou Wenbo , Wang Hao , Wu Dingguo , Wu Yunyang , Zhou Kuiping , Lian Yuanshu , Chang Gengyun , Feng Yuze , Liang Jifeng , Huang Gao 
Published: March 2023

IntroductionMalignant pancreatic cancer has poor long-term survival. Increasing evidence shows that FAM83A (family with sequence similarity 83 member A) plays a vital role in tumorigenesis and malignant progression in some human cancer types. The present study explored the potential mechanism of FAM83A in improving the prognosis of pancreatic cancer patients.MethodsTranscriptomic and clinical data from patients were obtained from The Cancer Genome Atlas while FAM83A expression was measured in tumorous pancreatic tissue compared with normal controls by quantitative real-time PCR and immunohistochemistry.ResultsFAM83A is a vital prognostic indicator and potential oncogene in pancreatic cancer via pan-cancer analysis. In silico analysis revealed that AL049555.1/hsa-miR-129-5p axis was the pivotal upstream ncRNA- mediated pathway of FAM83A in pancreatic cancer. Furthermore, FAM83A expression was related to immune cell infiltration through vital immune-related genes including programmed cell death 1 (PDCD1), and tumorigenesis through common mutation genes including KRAS protooncogene GTPase (KRAS), and SMAD family member 4 (SMAD4). In summary, ncRNA-mediated upregulation of FAM83A is associated with poor long-term survival and immune cell infiltration in pancreatic cancer.DiscussionFAM83A may be used as a novel survival-related and immune-related biomarker. This information suggests that FAM83A may be a novel therapeutic target for combined or individual treatment for patients with pancreatic cancer.
Exploring the bi-directional relationship and shared genes between depression and stroke via NHANES and bioinformatic analysis
Authors: Yang Zhanghuan , He Maokun , Zhang Qian , Li Shifu , Chen Hua , Liao Di 
Published: March 2023

Background: Stroke and depression are the two most common causes of disability worldwide. Growing evidence suggests a bi-directional relationship between stroke and depression, whereas the molecular mechanisms underlying stroke and depression are not well understood. The objectives of this study were to identify hub genes and biological pathways related to the pathogenesis of ischemic stroke (IS) and major depressive disorder (MDD) and to evaluate the infiltration of immune cells in both disorders.Methods: Participants from the United States National Health and Nutritional Examination Survey (NHANES) 2005–2018 were included to evaluate the association between stroke and MDD. Two differentially expressed genes (DEGs) sets extracted from GSE98793 and GSE16561 datasets were intersected to generate common DEGs, which were further screened out in cytoHubba to identify hub genes. GO, KEGG, Metascape, GeneMANIA, NetworkAnalyst, and DGIdb were used for functional enrichment, pathway analysis, regulatory network analysis, and candidate drugs analysis. ssGSEA algorithm was used to analyze the immune infiltration.Results: Among the 29706 participants from NHANES 2005–2018, stroke was significantly associated with MDD (OR = 2.79,95% CI:2.26–3.43, p &lt; 0.0001). A total of 41 common upregulated genes and eight common downregulated genes were finally identified between IS and MDD. Enrichment analysis revealed that the shared genes were mainly involved in immune response and immune-related pathways. A protein-protein interaction (PPI) was constructed, from which ten (CD163, AEG1, IRAK3, S100A12, HP, PGLYRP1, CEACAM8, MPO, LCN2, and DEFA4) were screened. In addition, gene-miRNAs, transcription factor-gene interactions, and protein-drug interactions coregulatory networks with hub genes were also identified. Finally, we observed that the innate immunity was activated while acquired immunity was suppressed in both disorders.Conclusion: We successfully identified the ten hub shared genes linking the IS and MDD and constructed the regulatory networks for them that could serve as novel targeted therapy for the comorbidities.
Comprehensive analysis of prognosis of cuproptosis-related oxidative stress genes in multiple myeloma
Authors: Li Tingting , Yao Lan , Hua Yin , Wu Qiuling 
Published: March 2023

Introduction: Multiple myeloma (MM) is a highly heterogeneous hematologic malignancy. The patients’ survival outcomes vary widely. Establishing a more accurate prognostic model is necessary to improve prognostic precision and guide clinical therapy.Methods: We developed an eight-gene model to assess the prognostic outcome of MM patients. Univariate Cox analysis, Least absolute shrinkage and selection operator (LASSO) regression, and multivariate Cox regression analyses were used to identify the significant genes and construct the model. Other independent databases were used to validate the model.Results: The results showed that the overall survival of patients in the high-risk group was signifificantly shorter compared with that of those in the low-risk group. The eight-gene model demonstrated high accuracy and reliability in predicting the prognosis of MM patients.Discussion: Our study provides a novel prognostic model for MM patients based on cuproptosis and oxidative stress. The eight-gene model can provide valid predictions for prognosis and guide personalized clinical treatment. Further studies are needed to validate the clinical utility of the model and explore potential therapeutic targets.
Preclinical efficacy of oncolytic VSV-IFNβ in treating cancer: A systematic review
Authors: Moglan Abdulaziz Molham , Albaradie Omar A. , Alsayegh Fares Fayez , Alharbi Hussam Mohsen , Samman Yahya Marwan , Jalal Mohammed M. , Saeedi Nizar H. , Mahmoud Ahmad Bakur , Alkayyal Almohanad A. 
Published: March 2023

BackgroundCancer incidence and mortality are increasing rapidly worldwide, necessitating further investigation into developing and optimizing emergent cancer therapies. Oncolytic viruses such as vesicular stomatitis virus encoding interferon β (VSV-IFNβ) have attracted considerable attention, as they offer great efficacy and safety profiles. This systematic review aimed to determine and compare the efficacy profile between VSV-IFNβ and non-treatment controls in preclinical cancer models.MethodologyThe Embase and Medline databases were systematically searched for relevant studies using related key terms and Medical Subject Headings (MeSH). Titles, abstracts, and full texts were screened, and data from eligible articles were extracted by two groups independently and in duplicate (two reviewers per group). Disagreements were resolved by a fifth independent reviewer. The included articles were all preclinical (translational) in vivo English studies that investigated and compared the efficacy profile between VSV-IFNβ and non-treatment controls in animal models. The risk of bias among the studies was assessed by two reviewers independently and in duplicate using SYRCLE’s risk-of-bias tool for animal studies; disparities were addressed by a third independent reviewer.ResultsAfter employing relevant MeSH and key terms, we identified 1598 articles. A total of 87 articles were either duplicates or conference proceedings and were thus excluded. Following title and abstract screening, 37 articles were included in the full-text assessment. Finally, 14 studies met the eligibility criteria. Forty-two experiments from the included studies examined the potential efficacy of VSV-IFNβ through different routes of administration, including intratumoral, intraperitoneal, and intravenous routes. Thirty-seven experiments reported positive outcomes. Meanwhile, five experiments reported negative outcomes, three and two of which examined intratumoral and intravenous VSV-IFNβ administration, respectively.ConclusionAlthough the majority of the included studies support the promising potential of VSV-IFNβ as an oncolytic virus, further research is necessary to ensure a safe and efficacious profile to translate its application into clinical trials.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022335418.
Autosomal recessive IL12RB1 mutation: A case report of a Sudanese child and his father
Authors: Abdelmajeed Omaima , Ali Muna Mohammed Dawoud , Erwa Nahla Hashim , Mustafa Alamin , Ahmed Yassin Abdelraheem , Ahmed Rogaia Hasap Alrasoul , Mohammed Hala Hamza Eltayeb , Hassan Malaz Elsadeg , Ahmed Monzir , Algam Shima 
Published: March 2023

IntroductionMendelian susceptibility to mycobacterial disease (MSMD) is a rare inherited condition characterized by selective susceptibility to weakly virulent mycobacteria, such as substrains of the bacille Calmette–Guérin (BCG) vaccine and different environmental mycobacteria.Case presentationA 7-year-old Sudanese boy was referred to the immunology clinic with a suspected diagnosis of MSMD. This followed multiple presentations with disseminated tuberculosis and typhoid fever. Genetic testing surprisingly revealed pathogenic homozygous variants in IL12RB1 Exon 9, c.913A&gt;T (p. Lys305*) in both the patient and his father, with a completely healthy asymptomatic carrier mother who is not blood related to the patient’s father.ConclusionIt is challenging to diagnose MSMD, especially in developing countries where health systems are poor and have limited resources. Family history and genetic tests may help in early MSMD treatment and avoiding disease complications.
Better or worse food: Nutrition value of the prey fishes and the potential health implications for Indo-Pacific humpback dolphins
Authors: Lin Jianqing , Liang Yan , Zhao Hancheng , Gutang Qilin , Wu Zonghuan , Gao Yan , Liu Sailan , Li Kunhuan , Wu Yinglin , Zhang Zonghang , Li Ping , Liu Wenhua 
Published: March 2023

IntroductionOverfishing and climate change have combined to cause fishery stocks to decline and fish community composition to change, further threatening the predation and nutritional health of marine mammals.MethodsIn this study, we collected potential prey fishes catched by fishermen in six habitats of Indo-Pacific humpback dolphins and analyzed their proximate composition (moisture, water, fat and protein), the fatty acid composition and the amino acid composition to evaluate the possible health effect on humpback dolphins.ResultsThe results showed that the nutritional composition varied significantly with species and locations. Fishes in the families Sciaenidae and Engraulidae displayed richer fatty acid composition, while those in the family Clupeidae had the highest value of amino acid quality index. In Zhuhai, home to the largest Indo-Pacific humpback dolphin population, pelagic/neritic prey fishes possessed lower energy density, PUFA content, PUFA/SFA ratio, DHA content, and EAA content compared to demersal fish, suggesting nutritional stress when there is a dietary switch from demersal to pelagic/neritic fishes in Zhuhai population.DiscussionOur study provided a framework, with energy density and fatty acid composition as its most important indicator, for assessment of the marine top predators based on the nutritional composition of their prey fishes and revealed the potential threats. Data here is expected to facilitate the development of scientific programs for successful conservation of not only the Indo-Pacific humpback dolphins, but also other marine top predators, possibly through reconstructing their prey fish’s quantity and quality.
Algicidal substances of Brevibacillus laterosporus and their effect on red tide organisms
Authors: Liu Shanshan , Yu Zhiming , Wu Zaixing , Cao Xihua , Cheng Ruihong , Song Xiuxian 
Published: March 2023

Herein, the algicidal effects of Brevibacillus laterosporus on typical red tide organisms were investigated. Through comparative analysis of the fermentation solution, sterile filtrate and bacterial body, it was found that this strain mainly exerts its algicidal function by secreting algicidal substances. In this paper, we established a method for extracting the algicidal substances of B. laterosporus and systematically investigated their features and effect on Heterosigma akashiwo. The results showed that the algicidal substances are a mixture of compounds all with molecular weights less than 3500 Da, with those below 100 Da producing 45% of the algicidal effect; these are more polar and best extracted with methanol. The algicidal substances are stable over a range of temperatures (-80.0 to 70.0°C) and pH values (4.0-8.0). The algicidal substances caused most H. akashiwo cells to rupture within 24 h. In the remaining cells, the algicidal substances activated the antioxidant system and reduced their metabolic activity, leading to apoptosis, as observed by cell crumbling and a reduction in membrane potential. The responses of different algal cell surface structures to the algicidal substances were also compared and analysed. It was concluded that these algicidal substances can act on the cell membrane and change its permeability, allowing entry of the algicidal substances to produce an algicidal effect.
Cortical metabolic characteristics of anti-leucine-rich glioma-inactivated 1 antibody encephalitis based on 18F-FDG PET
Authors: Wang Kai , Zhao Xiaobin , Yuan Leilei , Chen Qian , Wang Qun , Ai Lin 
Published: March 2023

PurposeA general glucose metabolism pattern is observed in patients with anti-leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis; however, it is unclear whether further subregional metabolic differences exist. Therefore, the present study aimed to conduct an in-depth exploration of the features of glucose metabolism within specific brain areas using 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET).Materials and methodsThis retrospective study enrolled thirteen patients confirmed with LGI1 antibody encephalitis who were admitted to Beijing Tiantan Hospital from June 2021 to September 2022. All patients underwent 18F-FDG PET before initiating clinical treatment. Changes in glucose metabolism in specific brain areas were analyzed using Cortex ID software. The laterality of 18F-FDG uptake was assessed, and differences in specific brain areas were compared using paired t-tests.ResultsSignificant metabolic changes in at least one brain region in 11 out of 13 patients (84.6%) were revealed by semi-quantitative analysis (z-score &gt; 2). A bilateral decrease in the 18F-FDG metabolic pattern was revealed in almost all brain regions of interest; in contrast, a hypermetabolic pattern was observed in the medial temporal region, with mean z-scores of 1.75 ± 3.27 and 2.36 ± 5.90 on the left and right sides, respectively (p = 0.497). In the prefrontal and temporal lobes, 18F-FDG metabolism was significantly lower in the lateral region than in the medial region on both sides. For the cingulate cortex, significant hypometabolism was also observed in the posterior part compared to the anterior counterpart on both the left (z-score: −1.20 ± 1.93 vs. −0.42 ± 1.18, respectively; p = 0.047) and right (z-score: −1.56 ± 1.96 vs. −0.33 ± 1.63, respectively; p = 0.001) sides. However, a significant difference in regional metabolism was observed only on the left side (p = 0.041).ConclusionAn asymmetric 18F-FDG metabolic pattern exists in patients with anti-LGI1 encephalitis. Meanwhile, varied regional metabolic differences were revealed bilaterally in specific cerebral areas, which could be associated with the clinical manifestations.
Promote identification or prevent expansion? The effect of uploader-viewer similarity on viewer inspiration in the context of short video community
Authors: Fu Senhui , Dai Haiwen 
Published: March 2023

IntroductionShort video communities have proliferated recently, opening up a new channel for the promotion of online businesses. The main challenge in marketing with short videos is how to inspire consumers.MethodsThis study employs viewer social identification and self-expansion as its entrance point to to explain how uploader-viewer similarity affects viewers’ short video inspiration. We use empirical investigation method based on the data of 310 short video viewers to test our conceptual model.ResultsWe found that there is a double-edged relationship between uploader-viewer similarity and short video inspiration. Particularly, uploader-viewer similarity enhances perceived social identification while reducing perceived self-expansion. The association between Uploader-viewer similarity and short video inspiration is moderated by viewers’ cognitive demands.DiscussionThese results provide a new perspective for enterprises to manage the relationship between viewers and media.
Cooking properties and nutrient retention of biofortified common bean (Phaseolus vulgaris) varieties: The case of Burundi
Authors: Muroki Mary W. , Waswa Lydiah M. , Fungo Robert , Kabwama Andrew , Mahungu Symon M. 
Published: March 2023

IntroductionCurrent research on micronutrient deficiency indicates positive outcomes associated with utilizing biofortified beans in mitigating nutrition-related iron and zinc deficiencies, primarily in Sub-Saharan Africa. The common bean is however not palatable in its raw state and requires cooking before consumption. Existing research on the cooking qualities and nutrient retention of these novel biofortified common bean varieties is nonetheless scant, notably in Burundi.Materials and methodsThis study determined water absorption capacity, cooking yield, cooking time, and iron and zinc retention of 9 biofortified common bean varieties with Kinure, a traditional non-biofortified variety, as the control. The study employed a 10 × 2 completely randomized design in a factorial arrangement. The first factor was bean varieties with ten levels, and the second was pre-treatment with two levels, soaking and not soaking. Standard methods were used to analyze cooking properties and mineral retention, and experiments replicated thrice. Data analysis was conducted at a 95% confidence level and included Analysis of Variance and t-test comparison studies. Post-hoc analysis was performed using Tukey's Honestly Significant Difference.Results and discussionCooking properties and mineral retention varied significantly between soaked and unsoaked bean varieties (P &lt; 0.05) and in comparison, to Kinure (P &lt; 0.05 and P &lt; 0.001). Water absorption capacity varied from 64.51% to 116.3%. Soaked beans recorded half the total cooking time needed to cook unsoaked beans (77.62 versus 156.86 minutes), had higher cooking yields (289.77% versus 259.82%), and reduced Fe (121.58 versus 167.8%) and Zn (127.74% versus 145.15%) retention. Compared to Kinure, soaking resulted in longer cooking times, lower cooking yields in the biofortified common beans, and an insignificant effect on their zinc retention. A significant correlation between iron and zinc retention (r = 0.445), water absorption capacity and iron retention (r = −0.0425) and water absorption capacity and zinc retention (r = −0.477) were recorded. Three clusters were also observed; iron and zinc retention, cooking yields, and water absorption capacity, and cooking time. It was observed that, soaking common beans before cooking reduces cooking time and increases cooking yield in both biofortified and traditional common bean varieties. Moreover, biofortified common beans are a good source of iron and zinc and could considerably alleviate micronutrient deficiencies, particularly in developing countries.