bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collaboration between the maxillofacial prosthodontists and the maxillofacial surgeons: Overview
Authors: El Hawari W. , Rokhssi H. , Zaroual A. , Bentahar O. 
Published: January 2023

Abstract
Given the diversity and complexity of maxillofacial loss of substances (LOS), its management requires the association of several specialties; the decision on a strategy or treatment plan is discussed during a multidisciplinary consultation meeting. However, this is unfortunately not always applied for reasons of the distance between health facilities or due to lack of time (or others).
This collaboration is crucial in cases of maxillary, mandibular and extra-oral LOS; A preoperative consultation is essential to discuss the predicted extent of the surgical procedures.
The maxillofacial prosthodontist designs devices for prevention, restraint, replacement, or reduction after obvious resection and/or repair surgery.
Through this work, we propose a link between the maxillofacial prosthodontist and the maxillofacial surgeon. It would allow to corroborate their collaboration and consequently to facilitate the good progress of the treatment.

Highlights
Reforming Medicaid Coverage Toward Reproductive Justice
Authors: Morcelle Madeline T. 
Published: January 2023

AbstractAs the United States’ largest public health insurance program, Medicaid has since 1965 played a crucial role in the struggle for equitable health care access. It has the potential to be a powerful instrument of reproductive justice, yet discriminatory policies that deny coverage for vital sexual, reproductive, or other health services, or exclude entire populations of people with low incomes from coverage altogether, constrain peoples’ health and reproductive futures. Resulting discrimination in Medicaid law and policy thwart the program’s ability to promote intergenerational health equity and reproductive justice for underserved communities.This Article provides an account of why reproductive justice is a necessary framework for examining, reimagining, and reforming Medicaid coverage law and policy. Part I gives a brief history and overview of reproductive justice, which serves as “an open source code that people have used to pursue fresh critical thinking regarding power and powerlessness.” Part II argues that we should utilize that open source code in Medicaid coverage reform. Using some of the reproductive justice movement’s critiques as a starting point, it explores how reproductive oppression has shaped Medicaid coverage law, policy, and mainstream reproductive and health care reform movements’ proposals, and to what effect. It argues that examining Medicaid law, policy, and proposed reforms through this lens and in collaboration with the reproductive justice movement can enable health advocates and policymakers to more fully understand, disrupt, and dismantle reproductive injustices that drive health inequities. Ultimately, it can empower reformers to build a more equitable public health insurance safety net that brings us closer to reproductive justice for all.
Sources of exposure and risk among employees infected with severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in a large, urban, tertiary-care hospital in the United States
Authors: Boomsma Cassidy , Poplausky Dina , Jasper Jacob M. , MacRae MacKenzie Clark , Tang Alice M. , Byhoff Elena , Wurcel Alysse G. , Doron Shira , Subbaraman Ramnath 
Published: January 2023

Abstract

Objective:
Hospital employees are at risk of SARS-CoV-2 infection through transmission in 3 settings: (1) the community, (2) within the hospital from patient care, and (3) within the hospital from other employees. We evaluated probable sources of infection among hospital employees based on reported exposures before infection.

Design:
A structured survey was distributed to participants to evaluate presumed COVID-19 exposures (ie, close contacts with people with known or probable COVID-19) and mask usage. Participants were stratified into high, medium, low, and unknown risk categories based on exposure characteristics and personal protective equipment.

Setting:
Tertiary-care hospital in Boston, Massachusetts.

Participants:
Hospital employees with a positive SARS-CoV-2 PCR test result between March 2020 and January 2021. During this period, 573 employees tested positive, of whom 187 (31.5%) participated.

Results:
We did not detect a statistically significant difference in the proportion of employees who reported any exposure (ie, close contacts at any risk level) in the community compared with any exposure in the hospital, from either patients or employees. In total, 131 participants (70.0%) reported no known high-risk exposure (ie, unmasked close contacts) in any setting. Among those who could identify a high-risk exposure, employees were more likely to have had a high-risk exposure in the community than in both hospital settings combined (odds ratio, 1.89; P = .03).

Conclusions:
Hospital employees experienced exposure risks in both community and hospital settings. Most employees were unable to identify high-risk exposures prior to infection. When respondents identified high-risk exposures, they were more likely to have occurred in the community.
The balance between critical thinking and paradigm thinking in the Arctic: Scientific cooperation across theoretical divides
Authors: Coote Michaela Louise 
Published: January 2023

Abstract
Kuhnian’ paradigms are a commonly used method of explaining the structure of knowledge production within the social sciences; however, in some ways, they are also in opposition with Popperian’ critical thinking. The opposing approaches surmount to a comparative analytic method – Kuhn advocates undertaking science that is incommensurable, discipline-specific and ideologically and metaphysically fixed in nature; whilst Popper advocates science that is pluralistic, rebellious, interdisciplinary, and ideologically and metaphysically adaptable. This article utilises a systematic literature review of key peer-reviewed articles, book chapters and online articles from respected sources relating to Arctic scientific cooperation during and since the Cold War in order to provide a qualitative data source for comparative theoretical analysis. This article analyses key trends in Arctic environmental decision-making since the Cold War utilising a comparative critical constructivist framework based on epistemological challenges visible in the “Science Wars” between Thomas Kuhn and Karl Popper. By applying two of the foundations of social science (critical thinking and paradigms) to Arctic International Relations and Geopolitics, this article assesses the state of Arctic science cooperation and; the potential for Arctic science cooperation to solve wicked environmental problems. The article concludes that there are power relationships within the epistemological background to environmental decision-making which impacts science cooperation in the Arctic and; current trends in Arctic decision-making further propels the Arctic along a trajectory of environmental degradation.
Linguistic and motor profiles in preschool and school-age children with an older sibling with autism spectrum disorder
Authors: GARRIDO Dunia , CARBALLO Gloria 
Published: January 2023

AbstractThis study examines receptive-expressive language, gross-fine motor skills, and IQ abilities in 78 children, 43 children with an older sibling with autism spectrum disorder (Sibs-ASD) and 35 children with an older sibling with typical development, ranging from 4 to 11 years of age. Depending on age, both groups were divided in preschool and school groups. The results show that more than 76% of Sibs-ASD performed at least one language and/or motor skill under 25th percentile. Significant differences were described at preschool stage in three aspects: grammatical comprehension, ball skills, and global motor skills. At school age, significant differences were found in two aspects: expressive language, and ball skills. Some differences seem to decrease over time; meanwhile others seem to increase; and others remain stable. Thus, it seems that vulnerability continues in unaffected Sibs-ASD and suggest that this population may benefit from continued screening and monitoring into the preschool and school-age stages.
Jaguars and wild pigs indicate protected area connectivity in the south-east Atlantic Forest (Brazil)
Authors: Silva Maitê Packer , Massi Klécia Gili , Negri Rogério Galante , Pedrosa Felipe 
Published: January 2023

SummaryThe Atlantic Forest of South America has undergone major changes due to urban and agriculture/pasture extension, resulting in a highly fragmented biome. Protected areas, created to ensure the biodiversity conservation of this biome, need to be connected for long-term landscape integrity. We aimed to quantify connectivity among protected areas in the south-east Atlantic Forest using two species with different environmental requirements: a threatened species with high requirements, the jaguarPanthera onca; and an exotic species with low requirements, the wild pigSus scrofa. Our methods included expert opinion, andCircuitscapeand least-cost-path analyses. We hypothesized that the patchy and altered landscape would not support the connectivity of jaguars but would allow wild pigs to transit. In fact, we found connectivity for both species, but there were more connectivity opportunities for wild pigs. The connection between Serra do Mar (and Serra do Mar state park) and Serra da Mantiqueira (Mantiqueira Mosaic) is narrow but possible to traverse through some protected areas of sustainable use and private reserves, highlighting the importance of these to structural landscape connectivity for the studied species in this region. The same connectivity that allows the transit of the native jaguar with high environmental requirements also allows the invasive wild pig to move through the landscape, which is worrisome.
Carnival and urban space in Athens, 1834–1940
Authors: Potamianos Nikos 
Published: January 2023

AbstractThis article explores the spatial dimensions of Athens' carnival and their change in the course of a century. It is based on two polarities: first, that of the old city and the new city, which was related to the contrast between traditional and modern culture in the celebration of carnival. Both the old city and traditional culture were increasingly undervalued and denounced until the inter-war years, when nostalgia for old places and practices developed. The second major contrast is that between the centre of Athens and its periphery. There was a strong tendency towards the concentration of carnival events and crowds in the centre of Athens until the 1900s. This development is correlated with the reinforcement of the middle class and its cultural hegemony. A new autonomy of the neighbourhoods of the popular classes in the inter-war period did not result in the revival of popular carnival culture.
Content analysis of on-package formula labelling in Great Britain: use of marketing messages on infant, follow-on, growing-up and specialist formula
Authors: Conway Rana , Esser Sara , Steptoe Andrew , Smith Andrea D , Llewellyn Clare 
Published: January 2023

AbstractObjective:To explore on-package formula messaging with reference to legislation and government-issued guidance in Great Britain (GB).Design:Formula products were identified, pictures of all sides of packs collated and on-package text and images were coded. Compliance with both GB legislation and guidance issued by the Department of Health and Social Care (DHSC) was assessed.Setting:All formula packs that were available for sale over the counter in GB between April and October 2020.Participants:Formula packs (n 71) including infant formula, follow-on formula, growing-up formula and specialist formula were identified, coded and analysed.Results:In total, 41 % of formula packs included nutrition claims, and 18 % included health claims that may be considered non-permitted, according to DHSC guidance. Additionally, 72 % of products showed images considered ‘non-permitted’. Breast Milk Substitute (BMS) legislation states infant and follow-on formula packs should be clearly distinguishable but does not provide criteria to assess similarity. Based on DHSC guidance, 72 % of infant and follow-on formula packs were categorised as showing a high degree of similarity. Marketing practices not covered by current legislation were widespread, such as 94 % of infant formula packs including advertisements for follow-on or growing-up formula.Conclusions:Text and images considered non-permitted according to DHSC guidance for implementing BMS legislation were widespread on formula products available in GB. As terms such as ‘similarity’ are not defined in BMS legislation, it was unclear if breaches had occurred. Findings support the WHO call for loopholes in domestic legislation to be closed as a matter of urgency.
Quantifying Coupling Effects Between Soil Matric Potential and Osmotic Potential
Authors: Hu Shaojie , Zhang Chao , Lu Ning 
Published: January 2023

AbstractSoil matric potential and osmotic potential are widely accepted as two independent components of total soil water potential. However, laboratory observations repeatedly demonstrated that matric potential can vary with salt concentration, implying a potential coupling between matric potential and osmotic potential. To date, it remains elusive whether matric potential and osmotic potential are independent or not and why so, and a theoretical theory for quantifying the coupling between them is still missing. Herein, a theoretical model is developed to quantitatively explain this problem via a lens provided by a recent concept of soil sorptive potential (SSP). The proposed model substantiates that matric potential and osmotic potential are not independent. The increasing salt concentration can notably depress two variables underpinning SSP, namely relative permittivity and electrical double layer thickness, leading to non‐negligible decreasing (more negative) of matric potential in the high suction range, and increasing (less negative) of it in the low suction range. In turn, the soil‐water interactions redistribute ions in soil water, raising osmotic potential especially for clay with high cation exchange capacity. The proposed model shows excellent performance in capturing experimental data, validating its accuracy. A parametric study implies that the neglection of coupling effects can lead to a significant underestimation of soil hydraulic conductivity in the film flow regime.
Asciminib vs bosutinib in chronic-phase chronic myeloid leukemia previously treated with at least two tyrosine kinase inhibitors: longer-term follow-up of ASCEMBL
Authors: Hochhaus Andreas , Réa Delphine , Boquimpani Carla , Minami Yosuke , Cortes Jorge E. , Hughes Timothy P. , Apperley Jane F. , Lomaia Elza , Voloshin Sergey , Turkina Anna , Kim Dong-Wook , Abdo Andre , Fogliatto Laura Maria , le Coutre Philipp , Sasaki Koji , Kim Dennis Dong Hwan , Saussele Susanne , Annunziata Mario , Chaudhri Naeem , Chee Lynette , García-Gutiérrez Valentin , Kapoor Shruti , Allepuz Alex , Quenet Sara , Bédoucha Véronique , Mauro Michael J. 
Published: January 2023

AbstractAsciminib, the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP), is approved worldwide for the treatment of adults with Philadelphia chromosome–positive chronic myeloid leukemia in chronic phase (CML-CP) treated with ≥2 prior tyrosine kinase inhibitors (TKIs). In ASCEMBL, patients with CML-CP treated with ≥2 prior TKIs were randomized (stratified by baseline major cytogenetic response [MCyR]) 2:1 to asciminib 40 mg twice daily or bosutinib 500 mg once daily. Consistent with previously published primary analysis results, after a median follow-up of 2.3 years, asciminib continued to demonstrate superior efficacy and better safety and tolerability than bosutinib. The major molecular response (MMR) rate at week 96 (key secondary endpoint) was 37.6% with asciminib vs 15.8% with bosutinib; the MMR rate difference between the arms, after adjusting for baseline MCyR, was 21.7% (95% CI, 10.53–32.95; two-sided p = 0.001). Fewer grade ≥3 adverse events (AEs) (56.4% vs 68.4%) and AEs leading to treatment discontinuation (7.7% vs 26.3%) occurred with asciminib than with bosutinib. A higher proportion of patients on asciminib than bosutinib remained on treatment and continued to derive benefit over time, supporting asciminib as a standard of care for patients with CML-CP previously treated with ≥2 TKIs.
Predicting the HER2 status in oesophageal cancer from tissue microarrays using convolutional neural networks
Authors: Pisula Juan I. , Datta Rabi R. , Valdez Leandra Börner , Avemarg Jan-Robert , Jung Jin-On , Plum Patrick , Löser Heike , Lohneis Philipp , Meuschke Monique , dos Santos Daniel Pinto , Gebauer Florian , Quaas Alexander , Walch Axel , Bruns Christiane J. , Lawonn Kai , Popp Felix C. , Bozek Katarzyna 
Published: January 2023

Abstract
Background
Fast and accurate diagnostics are key for personalised medicine. Particularly in cancer, precise diagnosis is a prerequisite for targeted therapies, which can prolong lives. In this work, we focus on the automatic identification of gastroesophageal adenocarcinoma (GEA) patients that qualify for a personalised therapy targeting epidermal growth factor receptor 2 (HER2). We present a deep-learning method for scoring microscopy images of GEA for the presence of HER2 overexpression.

Methods
Our method is based on convolutional neural networks (CNNs) trained on a rich dataset of 1602 patient samples and tested on an independent set of 307 patient samples. We additionally verified the CNN’s generalisation capabilities with an independent dataset with 653 samples from a separate clinical centre. We incorporated an attention mechanism in the network architecture to identify the tissue regions, which are important for the prediction outcome. Our solution allows for direct automated detection of HER2 in immunohistochemistry-stained tissue slides without the need for manual assessment and additional costly in situ hybridisation (ISH) tests.

Results
We show accuracy of 0.94, precision of 0.97, and recall of 0.95. Importantly, our approach offers accurate predictions in cases that pathologists cannot resolve and that require additional ISH testing. We confirmed our findings in an independent dataset collected in a different clinical centre. The attention-based CNN exploits morphological information in microscopy images and is superior to a predictive model based on the staining intensity only.

Conclusions
We demonstrate that our approach not only automates an important diagnostic process for GEA patients but also paves the way for the discovery of new morphological features that were previously unknown for GEA pathology.
Coupling of terahertz light with nanometre-wavelength magnon modes via spin–orbit torque
Authors: Salikhov Ruslan , Ilyakov Igor , Körber Lukas , Kákay Attila , Gallardo Rodolfo A. , Ponomaryov Alexey , Deinert Jan-Christoph , de Oliveira Thales V. A. G. , Lenz Kilian , Fassbender Jürgen , Bonetti Stefano , Hellwig Olav , Lindner Jürgen , Kovalev Sergey 
Published: January 2023

AbstractSpin-based technologies can operate at terahertz frequencies but require manipulation techniques that work at ultrafast timescales to become practical. For instance, devices based on spin waves, also known as magnons, require efficient generation of high-energy exchange spin waves at nanometre wavelengths. To achieve this, a substantial coupling is needed between the magnon modes and an electro-magnetic stimulus such as a coherent terahertz field pulse. However, it has been difficult to excite non-uniform spin waves efficiently using terahertz light because of the large momentum mismatch between the submillimetre-wave radiation and the nanometre-sized spin waves. Here we improve the light–matter interaction by engineering thin films to exploit relativistic spin–orbit torques that are confined to the interfaces of heavy metal/ferromagnet heterostructures. We are able to excite spin-wave modes with frequencies of up to 0.6 THz and wavelengths as short as 6 nm using broadband terahertz radiation. Numerical simulations demonstrate that the coupling of terahertz light to exchange-dominated magnons originates solely from interfacial spin–orbit torques. Our results are of general applicability to other magnetic multilayered structures, and offer the prospect of nanoscale control of high-frequency signals.
Modeling of intracranial tumor treating fields for the treatment of complex high-grade gliomas
Authors: Segar David J. , Bernstock Joshua D. , Arnaout Omar , Bi Wenya Linda , Friedman Gregory K. , Langer Robert , Traverso Giovanni , Rampersad Sumientra M. 
Published: January 2023

AbstractIncreasing the intensity of tumor treating fields (TTF) within a tumor bed improves clinical efficacy, but reaching sufficiently high field intensities to achieve growth arrest remains challenging due in part to the insulating nature of the cranium. Using MRI-derived finite element models (FEMs) and simulations, we optimized an exhaustive set of intracranial electrode locations to obtain maximum TTF intensities in three clinically challenging high-grade glioma (HGG) cases (i.e., thalamic, left temporal, brainstem). Electric field strengths were converted into therapeutic enhancement ratios (TER) to evaluate the predicted impact of stimulation on tumor growth. Concurrently, conventional transcranial configurations were simulated/optimized for comparison. Optimized intracranial TTF were able to achieve field strengths that have previously been shown capable of inducing complete growth arrest, in 98–100% of the tumor volumes using only 0.54–0.64 A current. The reconceptualization of TTF as a targeted, intracranial therapy has the potential to provide a meaningful survival benefit to patients with HGG and other brain tumors, including those in surgically challenging, deep, or anatomically eloquent locations which may preclude surgical resection. Accordingly, such an approach may ultimately represent a paradigm shift in the use of TTFs for the treatment of brain cancer.
Tardigrade small heat shock proteins can limit desiccation-induced protein aggregation
Authors: Hibshman Jonathan D. , Carra Serena , Goldstein Bob 
Published: January 2023

AbstractSmall heat shock proteins (sHSPs) are chaperones with well-characterized roles in heat stress, but potential roles for sHSPs in desiccation tolerance have not been as thoroughly explored. We identified nine sHSPs from the tardigrade Hypsibius exemplaris, each containing a conserved alpha-crystallin domain flanked by disordered regions. Many of these sHSPs are highly expressed. Multiple tardigrade and human sHSPs could improve desiccation tolerance of E. coli, suggesting that the capacity to contribute to desicco-protection is a conserved property of some sHSPs. Purification and subsequent analysis of two tardigrade sHSPs, HSP21 and HSP24.6, revealed that these proteins can oligomerize in vitro. These proteins limited heat-induced aggregation of the model enzyme citrate synthase. Heterologous expression of HSP24.6 improved bacterial heat shock survival, and the protein significantly reduced heat-induced aggregation of soluble bacterial protein. Thus, HSP24.6 likely chaperones against protein aggregation to promote heat tolerance. Furthermore, HSP21 and HSP24.6 limited desiccation-induced aggregation and loss of function of citrate synthase. This suggests a mechanism by which tardigrade sHSPs promote desiccation tolerance, by limiting desiccation-induced protein aggregation, thereby maintaining proteostasis and supporting survival. These results suggest that sHSPs provide a mechanism of general stress resistance that can also be deployed to support survival during anhydrobiosis.