bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endometrial extracellular matrix components do not change over the course of embryonic diapause and reactivation in the roe deer (Capreolus capreolus)
Authors: Rüegg Anna B. , Kowalewski Mariusz P. , Ulbrich Susanne E. 
Published: January 2023

AbstractThe modification of the endometrial extracellular matrix (ECM) is a crucial step for embryo implantation in many mammalian species. The embryo of the European roe deer (Capreolus capreolus) displays a 4–5 months long temporary reduction of developmental pace termed embryonic diapause. A reduction of epithelial cell height during diapause has previously been described. Co‐occurring ECM modifications may contribute to the changes of the intra‐uterine milieu during reactivation at which the embryo regains developmental velocity. We assessed the localization of five ECM proteins (collagen I and IV, fibronectin, laminin, and extracellular matrix protein 1) using immunohistochemistry in animals with early, late, and post‐diapause (elongating) embryos. While our results confirmed the reduction of epithelial height during diapause, we only detected marginal differences in localization and staining intensities of the selected ECM proteins. Major ECM remodelling events in the roe deer endometrium are thus likely to occur only at implantation.
Monetary policy transparency and real exchange rate adjustment
Authors: Lai Zheng‐Hao , Wu Jyh‐Lin 
Published: January 2023

AbstractWe study the effect of different attributes of monetary policy transparency on real exchange rate adjustment by estimating the half‐life of the real exchange rate. After controlling for sample‐selection bias, results from the panel error‐correction model suggest that the economic aspect of transparency facilitates real exchange rate adjustment in non‐industrial countries. The driving force behind this finding is that economic transparency enhances nominal exchange rate adjustment. However, none of the different attributes of monetary policy transparency significantly affect real exchange rate adjustment in industrial countries. Failure to control for sample‐selection bias over‐rejects the null hypothesis.
Changes in Everyday Internet Use and Home Activity During and After Pandemic‐Related Lockdowns: A Case Study in Shuangjing Subdistrict, Beijing
Authors: Li Chunjiang , Thulin Eva , Chai Yanwei 
Published: January 2023

AbstractThe outbreak of the COVID‐19 pandemic affected the everyday lives of people. Recent studies have found that Internet use increased during lockdowns and helped people cope with spatial constraints on daily activity. However, long‐term implications on the digitalization of everyday life are still unknown. This study aims to improve the understanding of changes in Internet use during and after lockdown and how these changes relate to home activity and activity context. We draw on a case study of pre‐, mid‐ and post‐lockdown periods in Shuangjing Subdistrict, Beijing. We find that Internet use increased during and after the lockdown, indicating a persistent effect. Home activity mediated the increase in Internet use, suggesting that people stayed at home engaging in more Internet use when restrictions were eased. Work activity and family affairs strengthened the positive impact on Internet use during the lockdown. The influence on Internet use differed depending on sociodemographic characteristics.
Telemental health for clinical assessment and treatment
Authors: Sugarman Dawn E , Busch Alisa B 
Published: January 2023

Abstract
Telemental health—the use of videoconferencing or audio only (telephone) in mental health care—has accelerated tremendously since the start of the covid-19 pandemic. Meta-analyses have examined the reliability (ie, concordance) of assessment and the efficacy/effectiveness of telemental health compared with in-person care. Results indicate that telemental health assessment and clinical outcomes are similar compared with in-person care but there is much unexplained variability, as well as evidence that patient clinical and demographic characteristics can influence these findings. Further, gaps exist in the literature regarding specific patient populations (eg, psychotic disorders, children/adolescents), treatment modalities (eg, group therapy), audio only telemedicine, and hybrid care that mixes in-person with telemental health care. These gaps provide important directions for the next generation of telemental health research. Comprehensive clinical guidelines from mental health organizations are available to telemental health practitioners and focus on five content themes: legal and regulatory issues, clinical considerations, standard operating procedures and protocols, technical requirements, and considerations of specific populations and settings.
Managing public water supply abstraction from a Chalk aquifer to minimize risk of deterioration of ecological status
Authors: Streetly Mike , Bishop Sam , Bradley David C. , Dunscombe Mark 
Published: January 2023

Abstract
The Cam and Ely Ouse Chalk aquifer has been an important source of public water supply for over 100 years. In response to growing demand for water in the area in the 1970s and 1980 s, the National Rivers Authority developed the Lodes–Granta scheme to provide augmentation water to key rivers, subject to low flows. However, during the droughts in the late 1990s, the River Granta, which derives baseflow from the Chalk aquifer, was dry in some locations for several months. In response, the Environment Agency and Cambridge Water carried out investigations into the impacts of abstraction on the flow and ecology of the Granta and agreed to restrict abstraction from two operational groundwater sources during low flow periods. However, these abstraction restrictions could potentially result in a shortfall within the relevant public water supply zone under some climatic conditions and so Cambridge Water was considering increasing abstraction from an alternative source of groundwater within the catchment to retain the level of resilience of its supply. The Environment Agency was concerned that use of this abstraction could pose a risk of deterioration of the ecological status of the water body under the EU Water Framework Directive. This paper describes the investigations undertaken to assess the risk of deterioration and shows how these are being used to manage this risk going forward.
Ordovician plate tectonic and palaeogeographical maps
Authors: Scotese Christopher R. 
Published: January 2023

Abstract
Plate tectonic and palaeogeographical maps are presented for nine time intervals during the Ordovician: early Tremadocian (485 Ma), late Tremadocian (480 Ma), early Floian (475 Ma), earliest Dapingian (470 Ma), early Darriwilian (465 Ma), late Darriwilian (460 Ma), middle Sandbian (455 Ma), middle Katian (450 Ma) and early Hirnantian (445 Ma). A plate model was used to predict the changing age of the ocean floor and, hence, the changing volume of the ocean basins and the resulting degree of continental flooding. The maps show the locations of active plate boundaries (i.e. subduction zones, mid-ocean rifts, transform faults, island arcs, back-arc basins and collision zones) and the age of the ocean floor. During the Ordovician there were six continental plates (Gondwana, Laurentia, Baltica, Cathaysia, Avalonia and Cuyania) and six oceanic plates (Iapetus, Ran, Kipchak, and Panthallasa 1, 2 and 3), as well as several poorly constrained back-arc basins (Zealandia, Alexander and Farwell). The palaeogeographical maps also illustrate the ancient distribution of mountains, land, shallow seas and deep ocean basins. Sea level was high during the Early Ordovician, fell during the middle Ordovician and rose again during the Late Ordovician. A precipitous fall in sea level occurred at the end of the Ordovician due to the short-lived Hirnantian Ice Age.
Pennsylvanian glacial cycles in western Gondwana: an overview
Authors: Iannuzzi Roberto , di Pasquo Mercedes M. , Vesely Fernando F. , Scherer Claiton M. S. , Andrade Luiz S. , Mottin Thammy , Kifumbi Carrel 
Published: January 2023

Abstract
The Pennsylvanian on the western rim of Gondwana can be considered a time of significant contrasts in terms of environments, revealing a unique translatitudinal disposition of the South American continent, where glaciomarine deposits and peat-forming environments, situated further south, coexisted with marine carbonate platforms and aeolian dune fields, in terrains further north. This peculiar record creates an opportunity to better understand the teleconnections of glaciation and deglaciation during the Late Paleozoic Ice Age (LPIA) between mid and low latitude regions. In the last decade, radiometric dating together with marine microfossils (mostly conodonts) has enabled a better understanding of the timing and duration of deposition of different sedimentary environments found in the climate belts that originated from a global ice-house regime. These advances in the chronostratigraphical positioning of sedimentary deposits also allow a more precise correlation between them, making it possible to estimate cause–effect patterns arising from the growth and decay of glaciers in this portion of Gondwana. This contribution aims to present an overview of the main climatic–environmental events that took place during the Pennsylvanian and to associate them with the floristic changes that occurred in the emergent lands based on palaeobotanic and palynological information. The record from the west rim of Gondwana could be roughly divided into Early, Middle and Late Pennsylvanian, exactly as proposed in the geological time-scale.
Large‐Scale Metabolomics and the Incidence of Cardiovascular Disease
Authors: Lind Lars , Fall Tove , Ärnlöv Johan , Elmståhl Sölve , Sundström Johan 
Published: January 2023

Background
The study aimed to show the relationship between a large number of circulating metabolites and subsequent cardiovascular disease (CVD) and subclinical markers of CVD in the general population.

Methods and Results

In 2278 individuals free from CVD in the EpiHealth study (aged 45–75 years, mean age 61 years, 50% women), 790 annotated nonxenobiotic metabolites were measured by mass spectroscopy (Metabolon). The same metabolites were measured in the PIVUS (Prospective Investigation of Vasculature in Uppsala Seniors) study (n=603, all aged 80 years, 50% women), in which cardiac and carotid artery pathologies were evaluated by ultrasound. During a median follow‐up of 8.6 years, 107 individuals experienced a CVD (fatal or nonfatal myocardial infarction, stroke, or heart failure) in EpiHealth. Using a false discovery rate of 0.05 for age‐ and sex‐adjusted analyses and
P
<0.05 for adjustment for traditional CVD risk factors, 37 metabolites were significantly related to incident CVD. These metabolites belonged to multiple biochemical classes, such as amino acids, lipids, and nucleotides. Top findings were dimethylglycine and N‐acetylmethionine. A lasso selection of 5 metabolites improved discrimination when added on top of traditional CVD risk factors (+4.0%,
P
=0.0054). Thirty‐five of the 37 metabolites were related to subclinical markers of CVD evaluated in the PIVUS study. The metabolite 1‐carboxyethyltyrosine was associated with left atrial diameter as well as inversely related to both ejection fraction and the echogenicity of the carotid artery.

Conclusions
Several metabolites were discovered to be associated with future CVD, as well as with subclinical markers of CVD. A selection of metabolites improved discrimination when added on top of CVD risk factors.
Long‐Term Outcomes and Duration of Dual Antiplatelet Therapy After Coronary Intervention With Second‐Generation Drug‐Eluting Stents: The Veterans Affairs Extended DAPT Study
Authors: Kinlay Scott , Young Melissa M. , Sherrod Rebecca , Gagnon David R. 
Published: January 2023

Background
Recent guidelines on dual antiplatelet therapy (DAPT) duration after percutaneous coronary intervention (PCI) balance the subsequent risks of major bleeding with ischemic events. Although generally favoring shorter DAPT duration with second‐generation drug‐eluting stents, the effects on long‐term outcomes in the wider population are uncertain.

Methods and Results
We tracked all patients having PCI with second‐generation drug‐eluting stents in the Veterans Affairs Healthcare System between 2006 and 2016 for death, myocardial infarction, stroke, and major bleeding up to 13 years. We compared these outcomes with 4 DAPT durations of 1 to 5, 6 to 9, 10 to 12, and 13 to 18 months after the index PCI using hazard ratios (HRs) and 95% CIs from Cox proportional hazards models adjusted by inverse probability weighting. A total of 40 882 subjects with PCI were followed up for a median of 4.3 (25%–75%: 2.4–6.5) years. DAPT discontinuation was rare early after PCI (5.8% at 1–5 months and 6.3% at 6–9 months) but increased (19% and 44%) >9 months. The risk of cardiovascular and noncardiovascular death was higher (HR, 2.03–3.41) with DAPT discontinuation <9 months, likely reflecting premature cessation from factors related to early death. DAPT discontinuation after 9 months following PCI was associated with lower risks of death (HR, 0.93 [95% CI, 0.88–0.99]), cardiac death (HR, 0.79 [95% CI, 0.70–0.90]), myocardial infarction (HR, 0.75 [95% CI, 0.69–0.82]), and major bleeding (HR, 0.82 [95% CI, 0.74–0.91]). Results were similar with an index PCI for an acute coronary syndrome.

Conclusions
Stopping DAPT after 9 months is associated with lower long‐term risks of adverse ischemic and bleeding events and supports recent guidelines of shorter duration DAPT after PCI with second‐generation drug‐eluting stents.
Inflection Points in Blood Pressure Trajectories Preceding Hypertension Onset in Different Age Groups
Authors: Liu Chengzhang , Zu Cheng , Meng Qiguo , Li Rui , Zhang Yuanyuan , He Panpan , Zhou Chun , Liu Mengyi , Ye Ziliang , Qin Xianhui 
Published: January 2023

Background
Understanding the natural history of elevated blood pressure (BP) is important to determine the window for primary prevention of hypertension. The authors aimed to investigate the natural history of elevated BP and examine whether there were inflection points in BP trajectories preceding hypertension onset in Chinese adults.

Methods and Results
A total of 8688 participants with an average of 5 BP measurements were included from the CHNS (China Health and Nutrition Survey). In each wave, triplicate measurements on the same arm were taken, and the mean systolic BP (SBP) and diastolic BP (DBP) were used in the analysis. Hypertension onset was defined as SBP ≥140 mm Hg or DBP ≥90 mm Hg or diagnosed by physician or currently under antihypertensive treatment. The median follow‐up time was 13.0 years. Overall, BP elevation with age prior to the onset of hypertension showed a nonlinear trajectory. The increased rates in both SBP and DBP were obviously faster after the inflection point than before. According to hypertension onset at age 30 to 39, 40 to 49, 50 to 59, 60 to 69, and 70 to 79 years, at the inflection point, patients were ≈29, 38, 48, 57, and 67 years, SBP levels were 112.6, 114.8, 116.8, 117.4, and 118.0 mm Hg, and DBP levels were 73.4, 75.7, 76.9, 76.2, and 73.8 mm Hg, respectively.

Conclusions
There was a nonlinear trajectory of BP elevation preceding hypertension onset. The inflection points for SBP and DBP were in the range of 112 to 118 mm Hg and 73 to 77 mm Hg, respectively. Once BP levels exceeded the changing points, the level of SBP and DBP increased more rapidly.
Characterization of fruit quality attributes and nutritional composition of ten blueberry cultivars
Authors: Hirzel Juan , Moya Victoria , Balbontín Cristián 
Published: January 2023

Abstract
The blueberry (Vaccinium corymbosum L.) have gained consumer interest worldwide for its antioxidant, neuroprotective, anti-cancer, anti-inflammatory, and blood pressure reducing properties. The objective of our study was to characterize 10 blueberry cultivars for firmness, weight, caliber, macronutrient content, anthocyanins, titratable acidity, and soluble solids. Results indicated that the characterized fruit parameters varied between 12.89–18.68 °Brix for soluble solids, 0.57%–0.79% for titratable acidity, 57.0–81.6 g mm −1 for firmness, 1.74 and 2.80 g for average fruit weight, 14.7 and 17.9 mm for average fruit diameter, 1.80–15.55 mg L−1 for anthocyanins, and 14.4%–21.6% for dry matter content. Fruit nutrient concentration (mg 100 g−1 fresh fruit) ranged from 63.6 to 104.0 mg N 100 g−1, 7.0 to 12.2 mg P 100 g−1, 76.4 to 122.7 mg K 100 g−1, 4.5 to 9.8 mg Ca 100 g−1, 3.6 to 6.9 mg Mg 100 g−1, and 3.7 to 5.8 mg S 100 g−1. The cultivar with the highest overall values was ‘Last Call’, while the cultivars with the lowest values were ‘Brigitta’, ‘Liberty’, and ‘Cargo’. There were positive and negative correlations between the characterization parameters, mainly 1) less firm cultivars, ‘Legacy’, ´Duke’, and ‘Camelia’, were positively correlated for the K concentration, 2) negative correlations between titratable acidity and the K concentration in ‘Last Call’, ‘Cargo’, ‘Brigitta’, and ‘Liberty’, and 3) positive correlations between the P concentration and soluble solid content in ‘Last Call’, ‘Camelia’, and ‘Brigitta’.
Building Thunderstorm Resilience in the Hindu Kush Himalaya Region through Probabilistic Forecasts and Satellite Observations
Authors: Case Jonathan L. , Gatlin Patrick N. , Srikishen Jayanthi , Adhikary Bhupesh , Mannan Md. Abdul , Bell Jordan R. 
Published: January 2023

Abstract
Some of the most intense thunderstorms on Earth occur in the Hindu Kush Himalaya (HKH) region of southern Asia—where many organizations lack the capacity needed to predict, observe, and/or effectively respond to the threats associated with high-impact convective weather. As a result, a disproportionately large number of casualties and damage often occur with premonsoon severe thunderstorms in this region. To address this problem, we combined ensemble numerical weather prediction (NWP), satellite-based precipitation products, and land-imagery techniques into a High-Impact Weather Assessment Toolkit (HIWAT) customized for HKH. In 2018 and 2019 demonstrations, a regional convection-allowing ensemble NWP system was configured to provide real-time probabilistic guidance of thunderstorm hazards over HKH, applying ensemble techniques developed for U.S.-focused experiments. Case studies of damaging wind, large hail, lightning, a rare Nepalese tornado, and landfalling tropical cyclone events show how HIWAT efficiently packages ensemble output into products that are readily interpreted by forecasters in HKH. Precipitation and total lightning flash verification reveal the highest skill occurred where deep convection was most frequently observed in Bangladesh and northeastern India, and verification scores exceeded global ensemble scores for heavy precipitation rates. These results demonstrate that plausible forecasts of thunderstorm hazards can be attained with relatively low computational resources, thereby facilitating advancements in extreme weather forecasting services in historically underserved regions such as HKH. In early 2022, a custom version of HIWAT was installed at the Bangladesh Meteorological Department using in-house computational resources, providing regional ensemble forecast guidance in real time.
Events of the Cross-Equatorial Flows over the Maritime Continent during 1979–2020
Authors: Zhao Xiaoxuan , Lu Riyu , Sun Jianqi 
Published: January 2023

Abstract
This study proposed a definition of the cross-equatorial flow (CEF) events over the Maritime Continent (MC) based on the daily mean data derived from ERA5 from 1979 to 2020. Following this definition, a total of 138 CEF events were identified. The statistical analysis suggests that CEF events are concentrated from May to October, with the peak frequency appearing in July. The occurrence frequency generally decreases along with the increase in duration, with a total of 66% of events persisting no longer than the average (7.1 days), while approximately 16% persist exceeding 10 days. The intensity of events is generally the strongest in August, consistent with the climatological annual cycle of CEF. The CEF events are characterized by a seesaw pattern of equatorial meridional wind anomalies between the upper and lower troposphere, with the strongest southerly (northerly) anomalies located at 925 (150) hPa. Both the upper- and lower-level wind anomalies propagate westward along with the evolution of events. The CEF events are highly connected with the tropical dipole convection, featured by the enhanced convection over the western North Pacific (WNP) and suppressed convection over MC. The convection enhancement over the WNP can be traced back to the equatorial central Pacific, which explains the westward movement of the events-related equatorial meridional wind anomalies. By contrast, the suppressed convection over the Indian Ocean and MC keeps stagnant. The events-related convection anomalies act as a branch of boreal summer intraseasonal oscillations (BSISOs), but CEF events are not fully dependent on BSISOs.
Purple urine in Berdon syndrome: a rare finding in the clinic laboratory
Authors: Oliveira Rodríguez Myriam , Moreno Rodríguez María , Díaz Martín Juan J , Prieto García Belén 
Published: January 2023

Introduction Purple Urine Bag Syndrome (PUBS) is a rare disorder seen in elderly persons, wherein the urinary bag and the tubing turn in to purple colour. It is usually seen in patients who are on urinary catheters for a long time. It consists of a change in the colour of the urine that turns purple in a very specific context. Case report We report the case of a paediatric female patient with Berdon Syndrome with symptoms consistent with urinary tract infection and purple urine discolouration. Urine test revealed leukocyturia and bacteriuria. Discussion Several risk factors have been proposed regarding this syndrome. Among them the commonest are female gender, advanced age, kind of diet (increased dietary tryptophan), alkaline urine and diverse situations that leads to urinary retentions which allows bacteria to work on their substrate for a longer time. Although it is a process that is not associated with gravity, recognizing it is important as treatment is simple and can minimize patient and family distress.