bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standard Model in the early Universe
Authors: Gromov N. 
Published: September 2023

A new hypothesis is put forward that the gauge group of the
Standard Model becomes simpler with increasing temperature
of the Universe, i.e. when moving back in time to the moment
of its occurrence. It is assumed that this simplification
is achieved by contracting the gauge group with the contraction
parameter, which decreases with increasing temperature.
In this case, the Lagrangian of the Standard Model is
divided into terms that differ in powers of the contraction parameter.
This makes it possible to arrange in time the stages
of development of the Standard Model as the Universe cools.
The evolution of the properties of elementary particles and
their interactions, starting from the Planck scale of 1019 GeV,
is based on the explicit form of intermediate Lagrangians and
explain the development of the Universe from simpler to more
complicated structures - and not vice versa. The contraction
hypothesis of the gauge group of the Standard Model contradicts
the available experimental data on the Higgs boson production
cross section.
Tensor extensions of Lax equations
Authors: Karabanov A. 
Published: September 2023

The Lax equations dL/dt = [M,L] play an important role in
the integrability theory of nonlinear evolution equations and
quantum dynamics. In this work, tensor extensions of the
Lax equations are suggested with M : V → V and L :
Tk(V ) → V , k = 1, 2, . . ., on a complex vector space V .
These extensions belong to the generalised class of Lax equations
(introduced earlier by Bordemann) dL/dt = ρk(M)L
where ρk is a representation of a Lie algebra. The case k = 1,
ρ1 = ad corresponds to the usual Lax equations. The extended
Lax pairs are studied from the point of view of isomorphic
deformations of multilinear structures, conservation
laws, exterior algebras and cochain symmetries.
Dermatofibrosarcoma protuberans de mama con reconstrucción con colgajo del dorsal ancho. Reporte de caso
Authors: Guevara Pacheco Jhon 
Published: September 2023

El Dermatofibrosarcoma Protuberans es un tumor cutáneo fibrohistiocítico, extremadamente raro y representa menos del 1% de los tumores mamarios. Se caracteriza por un lento crecimiento, pero con comportamiento infiltrante con altas tasas de recidiva local. Se puede sospechar clínicamente, la confirmación es histopatológica y se debe complementar con inmunohistoquímica. El tratamiento de elección es quirúrgico. Se presenta el caso de una mujer de 23 años con Dermatofibrosarcoma Protuberans de mama derecha, sometida a tumorectomía y reconstrucción inmediata de colgajo de dorsal ancho. La paciente tuvo evolución satisfactoria, sin evidencia de enfermedad.
MULTIPHASIC SCREENING: CLINICAL SYMPTOMS AND MENTAL HEALTH PATIENT TUBERCULOSIS IN JAMBI CITY, INDONESIA
Authors: Izhar M. Dody , Wardiah Rizalia , Lanita Usi , Herwansyah  
Published: September 2023

Background: Multiphasic screening with GeneXpert MTB/RIF and PHQ-9 is a solution for achieving successful conversion of intensive phase sputum examination. Purpose: To determine the effectiveness and feasibility of multiphasic screening for clinical symptoms and mental health in patients using the Tuberculosis Directly Observed Therapy (TB-DOTS) strategy. Methods: This study used a survey approach with a one-sample multiple testing screening method on the case finding and mental health of patients with TB. This screening was carried out in two stages: Stage I, suspected TB screening, and Stage II, mental health screening of TB patients undergoing intensive treatment (two months). Samples were taken from 160 TB suspects who came to health centers in Jambi City from August 1 to October 1, 2022, using proportionate stratified random sampling. Data were analyzed using statistical software to determine the accuracy and feasibility of screening. Results: Sputum conversion (Smear [-]) was 97.78% and the prevalence of mental health problems in patients was 22.22%. Stage I screening (suspected TB [GeneXpert MTB/RIF]): cough >2 weeks sensitivity, 94.84%; PPV, 97.35%; and accuracy, 92.50%. Stage II screening (patient mental health [PHQ-9]) with a validity of 9 items in the range of 0.17-0.66; ICC (interclass correlation coefficient [ICC], 0.60-0.83; Cronbach's a coefficient, 0.88). Multiphasic yield screening is recommended to achieve a better treatment success rate. Conclusion: Early detection of cases and mental health problems of TB patients in the early phase of treatment is a solution for developing a TB-DOTS strategy at first-level health facilities.
AN EPIDEMIOLOGICAL OVERVIEW OF DENGUE HEMORRHAGIC FEVER (DHF) CASES IN KEDIRI REGENCY DURING 2017-202
Authors: Amalia Febrianti Faradillah , Qurniyawati Eny , Atoillah Isfandiari Muhammad , Mohamed Gomaa Nasr Nayla 
Published: September 2023

Background: Dengue Hemorrhagic Fever (DHF) is a communicable disease with rapid spread and the potential to cause death. In 2019, Kediri District had the fourth-highest number of DHF cases in East Java Province and was reported to have experienced a DHF outbreak. Objective: This study aimed to describe dengue cases in Kediri District in 2017-2021 under non-pandemic and COVID-19 pandemic conditions. Methods: Using a total sampling technique, descriptive research with a case series design was conducted using secondary data from the Health Profiles and the Central Bureau of Statistics of Kediri District in 2017-2021. The studied variables included the number of dengue cases, sex, age, area, population, population density, morbidity rate, Lateral Flow Immunoassay (LFI), and rainfall. Data were analyzed using an epidemiological approach based on people, places, and times and visualized with tables and diagrams. Results: The majority of DHF cases occurred in males and the 5-14 years age group in both the COVID-19 non-pandemic (52.88%; 55.96%) and COVID-19 pandemic conditions (51.14%; 58.56%). The incidence rate (IR) increased with population density and the number of dengue cases in the non-COVID-19 pandemic. It decreased with a decrease in dengue cases when the population density increased during the COVID-19 pandemic. Under all conditions, high dengue cases were found in months with high rainfall. Conclusion: The pattern of DHF incidence in Kediri District in 2017-2021 is mostly in males and the age group of 5-14 years, when there is an increase in population density, and in January.
ANALYSIS OF DOMINANT RISK FACTORS FOR HYPERTENSIVE DISEASE
Authors: Bastira Ginting Johannes , Suci Tri 
Published: September 2023

Background: Hypertension is a non-communicable disease with a high morbidity and mortality rate. This disease frequently triggers the iceberg phenomenon as numerous individuals remain unaware of the affliction. Aim: This study determines the most dominant risk factors for the incidence of hypertension. Methods: The quantitative study method used was conducted in September 2022. The study population utilized secondary data sourced from the Visit data at the Johar Baru Health Center in South Jakarta during 2021. The initial dataset consisted of 102,647 patients, out of which 13,946 had hypertension. Furthermore, data analysis involved employing the Chi-square test and Multiple Logistic Regression, with a significance level of 95%. Results: The Chi-Square test yielded significant results, indicating a relationship between risk factors for hypertension and seven out of the nine free variables examined. These variables included Body Mass Index (BMI) (p-value=0.000), excess salt consumption (p-value=0.000), underfeeding fruits and vegetables (p-value=.000), lack of physical activity (p-value=0.000), excess fat consumption (p-value=0.000), gender (p-value=0.000), and age (p-value=0.000), with a p-value of <0.05. Meanwhile, smoking (p-value=0.516) and drinking alcohol (p-value=0.859) variables, with a p-value of >0.05 had no relationship. Conclusion: The result showed that BMI was the most dominant risk factors for hypertension, with an OR of 1,610. Therefore, people with an abnormal BMI have a 1,610 times risk of developing hypertension.
THE EFFECT OF COMORBIDITIES ON MORTALITY IN COVID-19 PATIENTS IN dr RADEN SOEDARSONO HOSPITAL PASURUAN
Authors: Puspita Kencana Lidia , Diah Kartiningrum Eka , Mafticha Elyana 
Published: September 2023

Background: COVID-19 patients with comorbidities have the highest mortality risk in Indonesia during the pandemic. Purpose: This study purposed to determine the prevalence of comorbidities on mortality of COVID-19 patients at RSUD dr. Raden Soedarsono, Pasuruan. Methods: This study used a case-control design with 560 samples collected from January until December 2021. The samples consisted of 140 COVID-19 patients who were treated at RSUD dr. Raden Soedarsono, Pasuruan, in 2021 and declared dead as a case group, as well as 420 COVID-19 patients treated at RSUD dr. Raden Soedarsono, Pasuruan, in 2021 but did not die as a control group. The data were then analyzed using a logistic regression test with SPSS 22.0. Results: The results show that almost all COVID-19 patients did not have comorbidities of diabetes mellitus (85.50%), autoimmune (98.60%), kidney disease (98.20%), gastrointestinal diseases (92.10%), thrombosis and coagulation disorders (93.60%), myocardial injury (99.30%), heart failure (94.30%), hypertension (95.20%), and tuberculosis (5.70%). Also, almost all COVID-19 patients did not have comorbidities of geriatrics (71.60%), COPD (64.10%), and mortality status (25.00%). The results of the logistic regression test show that comorbidities of diabetes mellitus (P-value 0.01; OR 1.99) and geriatrics (P-value 0.00; OR 2.82) affect mortality in COVID-19 patients. Whereas comorbidities of autoimmune (P-value 0.84), kidney disease (P-value 0.37), gastrointestinal diseases (P-value 0.73), thrombosis and coagulation disorders (P-value 0.24), myocardial injury (P-value 0.84), heart failure (P-value 0.43), hypertension (P-value 0.93), COPD (P-value 0.86), and tuberculosis (P-value 0.15) do not affect mortality inCOVID-19 patients. Conclusion: Diabetes Mellitus and geriatrics are the most significant comorbidities in causing the death of COVID-19 patients at RSUD dr. Raden Soedarsono, Pasuruan.
MAPPING SPREAD OF COVID-19 CASES IN TODDLERS AND CHILDREN AT CENTRAL JAVA USING K-MEANS CLUSTER
Authors: Widianawati Evina , Ratna Wulan Widya , Tri Wahyuni Anis , Agiwahyuanto Faik 
Published: September 2023

Background: Toddlers and children under 12 are still easily sick, particularly during the COVID-19 epidemic. The high number of COVID-19 cases in toddlers and children in Central Java Province must be monitored to prevent transmission to toddlers and children still susceptible to the disease. Purpose: The purpose of this study was to map the spread of COVID-19 cases in toddlers aged 0-5 years and children aged 6-11 years in the province of Central Java using the K-means cluster Methods: This was a descriptive observational study with a cross-sectional design. Data on COVID-19 cases in children 6-11 years and toddlers 0-5 years from 35 cities in Central Java in 2020-2021 were analyzed using the K-means cluster. The K-means cluster was used to cluster low, medium, and high cases and then map the spread of COVID-19. Results: Semarang, Semarang Regency, Boyolali, Klaten, Surakarta, and Banyumas became high cluster areas in cases of COVID-19 toddlers and children in 2021. Based on the mapping data, COVID-19 spread in young children and toddlers in 2020 and 2021 followed a nearly identical pattern. The high zone of COVID-19 in toddlers and children mostly had a higher total population, healthcare facilities, and population density than the medium and low zones. Conclusion: Semarang City, Semarang Regency, Boyolali, Klaten, Surakarta, and Banyumas should be looking for COVID-19 cases in toddlers and young children.
T817MA regulates mitochondrial dynamics via Sirt1 and Arc following subarachnoid hemorrhage
Authors: Chen Wei-Wei , Sun Fu-Qiang , Wang Bo , Tian Xiao-Xiao , Zhang Rong-Ping , Liu Wen-Bo , Chen Tao 
Published: September 2023

Abstract
Spontaneous subarachnoid hemorrhage (SAH) is an acute neurologic emergency with poor outcomes, and mitochondrial dysfunction is known as one of the key pathological mechanisms underlying the SAH-induced early brain injury (EBI). 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate (T817MA) is a newly synthesized neurotrophic compound that has been demonstrated to exert protective effects against brain injury. Here, we investigated the effect of T817MA in neuronal injury following experimental SAH both in vitro and in vivo. Primary cultured cortical neurons were treated with oxyhemoglobin(OxyHb) to mimic SAH in vitro, and T817MA at concentrations higher than 0.1 μM reduced OxyHb-induced neuronal injury. T817MA treatment significantly inhibited lipid peroxidation, reduced neuronal apoptosis and attenuated mitochondrial fragmentation. The results of western blot showed that T817MA markedly reduced the expression of mitochondrial fission proteins, fission protein 1 (Fis-1) and dynamin-related GTPase-1 (Drp-1), but prolonged the expression of the postsynaptic protein activity-regulated cytoskeleton-associated protein (Arc). In addition, T817MA significantly increased the expression of sirtuin 1 (Sirt1), which was accompanied by preserved enzymatic of isocitrate dehydrogenase (IDH2) and superoxide dismutase (SOD). Knockdown of Sirt1 and Arc via small interfere RNA (siRNA) transfection partially prevented the T817MA-induced protection in cortical neurons. Furthermore, treatment with T817MA in vivo significantly reduced brain damage and preserved neurological function in rats. The decreased expression of Fis-1 and Drp-1, as well as the increased expression of Arc and Sirt1 were also observed in vivo. Taken together, these data indicate that the neuroprotective agent T817MA protects against SAH-induced brain injury via Sirt1- and Arc-mediated regulation of mitochondrial dynamics.
The Metabolome-Wide Signature of Major Depressive Disorder
Authors: Jansen Rick , milaneschi yuri , Schranner Daniela , Kastenmüller Gabi , Arnold Matthias , Han Xianlin , Dunlop Boadie , Rush A , Kaddurah-Daouk Rima , Penninx Brenda 
Published: September 2023

Abstract

Major Depressive Disorder (MDD) is an often-chronic condition with substantial molecular alterations and pathway dysregulations involved. Single metabolite, pathway and targeted metabolomics platforms have indeed revealed several metabolic alterations in depression including energy metabolism, neurotransmission and lipid metabolism. More comprehensive coverage of the metabolome is needed to further specify metabolic dysregulation in depression and reveal previously untargeted mechanisms. Here we measured 820 metabolites using the metabolome-wide Metabolon platform in 2770 subjects from a large Dutch clinical cohort with extensive depression clinical phenotyping (1101 current MDD, 868 remitted MDD, 801 healthy controls) at baseline and 1805 subjects at 6-year follow up (327 current MDD, 1045 remitted MDD, 433 healthy controls). MDD diagnosis was based on DSM-IV psychiatric interviews. Depression severity was measured with the Inventory of Depressive Symptomatology self-report. Associations between metabolites and MDD status and depression severity were assessed at baseline and at the 6-year follow-up. Metabolites consistently associated with MDD status or depression severity on both occasions were examined in Mendelian randomization (MR) analysis using metabolite (N=14,000) and MDD (N=800,000) GWAS results. At baseline, 139 and 126 metabolites were associated with current MDD status and depression severity, respectively, with 79 overlapping metabolites. Six years later, 34 out of the 79 metabolite associations were subsequently replicated. Downregulated metabolites were enriched with
long-chain monounsaturated (P=6.7e-07) and saturated (P=3.2e-05) fatty acids and upregulated metabolites with lysophospholipids (P=3.4e-4). Adding BMI to the models changed results only marginally. MR analyses showed that genetically-predicted higher levels of the lysophospholipid 1-linoleoyl-GPE (18:2) were associated with greater risk of depression. The identified metabolome-wide profile of depression (severity) indicated altered lipid metabolism with downregulation of long-chain fatty acids and upregulation of lysophospholipids, for which causal involvement was suggested using genetic tools. This metabolomics signature offers a window on depression pathophysiology and a potential access point for the development of novel therapeutic approaches.
Comparative variability of nutrients, minerals, phenolics and anthocyanins with antioxidant potentials during fruit development stages in five Mulberry (Morus) cultivars
Authors: Saeed Asma , Kauser Shabana , Hussain Adil , Nadeem Abad Ali 
Published: September 2023

Abstract
BACKGROUND: The versatility of mulberry from the Morus genus is growing among various suppliers and users globally. OBJECTIVES: To assess the variations in total sugar, acidity, minerals, phenolics and anthocyanins and antioxidant dynamics of three black mulberry (Morrus serrata, M. nigra and M. macroura black) and two white mulberry cultivars (M. alba and M. macroura white) during development stages. METHODS: Total sugars and titratable acidity were evaluated with AOAC methods and TPC was estimated with folin-ciocalteau method. The antioxidant activity was determined with DPPH assay, minerals were quantified with atomic absorption spectroscopy and anthocyanins were assessed with pH differential assay and identified with HPLC and LC-MS. RESULTS: Over all, M. alba (white cultivar) displayed maximum sugar (1.35%) at development stage 3 (FDS-3) followed by M. serrata (black cultivar) at FDS-5 (1.1%) and M. macroura white (white cultivar) at FDS-4 (0.9%). A decreasing trends in acidity in M. alba (0.8-0.09%), M. nigra (0.8-0.03%) and M. macroura white (0.6-0.04%) were observed during development. TPC was maximum (590 GAE/100g) in M. nigra at FDS-6 and M. serrata (450 GAE/100g) at FDS-7. Two black cultivars (M. serrata and M. nigra) showed significant increase in total anthocyanins (14.57-100.06 and 14.13-201.87 CGE/100g FW) from FDS-1 to FDS-7 while decrease in M. macroura black and M. macroura white (17.07-11.79 and 9.03-2.68) from FDS-1 to FDS-7. The DPPH inhibition of black mulberry cultivars was pointedly greater with elevated levels of Fe, Cu, Zn, Ca, Mg, Na, P and K than white cultivars during maturity. HPLC and MS procedures identified various anthocyanins in all mulberry cultivars including cyanidin, cyanidin rutinoside, mono glucosides of malvidin, pelargonidin and delphinidin. CONCLUSIONS: The selection of mulberries with improved nutrition, acceptable range of metals, bioactive compounds and higher antioxidant potentials could be a significant natural cure against health related complications such as diabetes and other metabolic syndromes.
Arbuscular mycorrhizal fungi, phosphate-solubilizing bacteria, and zinc foliar application improve physiological responses in black cumin (Nigella sativa) under drought stress
Authors: Rafiee Somayeh , Yadavi Alireza , Dehnavi Mohsen Movahhedi , Balouchi Hamidreza 
Published: September 2023

Abstract

This research aimed to improve the physiological response of Nigella sativa to drought stress using arbuscular mycorrhizal fungi, phosphate-solubilizing bacteria, and zinc foliar application. The results demonstrated that the reduction in irrigation water significantly impacted photosynthetic pigments, relative water content, electrolyte leakage, proline content, leaf-soluble sugars, soluble proteins, biological yield, and grain yield. In addition, in 2018 and 2019 years elevated drought stress decreased total chlorophyll (63 and 71%), carotenoids (59 and 59%), relative water content (22 and 25%), soluble proteins content (34 and 35%), biological performance (48 and 55%), and grain yield (66 and 67%). Furthermore, it increased electrolyte leakage (112 and 104%), proline (128 and 120%), and soluble sugars content (44 and 38%). The combined use of arbuscular mycorrhizal fungus (AMF) and Phosphate barvar-2 bio-fertilizer (PB2) (containing two types of phosphate-solubilizing bacteria: Pseudomonas putida P13 and Pantoea agglomerans P5) alleviated for the decrease in the measured traits. Consequently, applying bio-fertilizer increased biological performance (59 and 60%) and grain yield (58 and 58%) and decreased electrolyte leakage (34 and 31%) compared to no bio-fertilizer application. Moreover, the combination of AMF and PB2 increased the grain nitrogen (66 and 40%) and grain phosphorus (27and 36%). Zinc foliar application increased grain elements content, photosynthesis pigment, proline, soluble sugars content, soluble protein content, relative water content and biological performance. Furthermore, it decreased electrolyte leakage. Bio-fertilizers and zinc foliar application mitigated the detrimental effects of drought stress on the quality, grain yield, and biological performance of black cumin by improving the physiological mechanisms.
Vaginal axis on MRI after laparoscopic pectopexy surgery: a controlled study
Authors: sahin fatih , bayraktarli recep yılmaz 
Published: September 2023

Abstract
Background
Laparoscopic pectopexy has emerged as a feasible alternative to sacrocolpopexy (SCP) for treating female genital apical prolapse. Although several previous studies have reported changes in the vaginal axis in women who have undergone SCP, laparoscopic lateral mesh suspension, sacrospinous ligament fixation surgery for prolapse, there is a lack of data on changes in the vaginal axis after pectopexy. The aim of this study was to evaluate the degree of anatomical correction achieved by laparoscopic pectopexy in patients with apical genital prolapse using magnetic resonance imaging (MRI).
Methods
Individuals who experienced pectopexy and a nulliparous control group were enrolled in this prospective observational case-control investigation. MRI scans were conducted on both the control cohort and the study group before and after the procedure. The angles formed by the pubococcygeal line and the inferior vaginal segment, the levator plate and the pubococcygeal line, as well as the inferior and superior vaginal segments, were measured and compared.
Results
The change in angle between the lower vagina and upper vagina was statistically significant, with preoperative and postoperative values of 134.91° ± 6.25° and 166.82° ± 6.15°, respectively (p = 0.0001). The angle between the lower vagina and pubococcygeal line showed a significant change, with preoperative and postoperative values of 44.64° ± 1.8° and 65.73° ± 10.19°, respectively (p = 0.0001). Postoperative angles were not similar among nulliparous patients based on the MRI findings. The postoperative Urogenital Distress Inventory scores are significantly lower than the preoperative scores (p = 0.0001).
Conclusions
The pectopexy procedure is not optimal for achieving a normal vaginal axis.
Trial registration number/date:
NCT05876975/ 26.05.2023