bluuebunny/crossref_metadata_2025_split huggingface dataset:
Source‐to‐sink mass‐balance analysis of an ancient wave‐influenced sediment routing system: Middle Jurassic Brent Delta, Northern North Sea, offshore UK and Norway
Authors: Okwara Ikenna C. , Hampson Gary J. , Whittaker Alexander C. , Roberts Gareth G. , Ball Patrick W. 
Published: March 2023

AbstractSediment mass‐balance analysis provides key constraints on stratigraphic architecture and its controls. We use the data‐rich Middle Jurassic Brent Delta sediment routing system in the proto‐Viking Graben, Northern North Sea, to estimate sediment budgets and mass‐balance between source areas and depositional sinks. Published studies are synthesised to provide an age‐constrained sequence stratigraphic framework, consisting of four previously defined genetic sequences (J22, J24, J26, J32). Genetic sequence J32 (3.9 Myr) records transverse progradation of basin‐margin deltas, sourced from the Shetland Platform to the west and Norwegian Landmass to the east. Genetic sequences J24 (1.1 Myr) and J26 (0.9 Myr) record the rapid progradation and subsequent aggradation of the Brent Delta along the basin axis, sourced from the uplifted Mid‐North Sea High to the south, and the western and eastern source regions. Genetic sequence J32 (2.2 Myr) records the retreat of the Brent Delta. Sediment budgets for the four genetic sequences are estimated using palaeogeographical reconstructions, isopach maps, and sedimentological analysis of core and well‐log data. The estimated net‐depositional sediment budget for the mapped Brent Delta system is 2.0–2.8 Mt/year. Temporal variations in net‐depositional sediment budget were driven by changes in tectonic boundary conditions, such as the onset of uplift before the deposition of genetic sequence J24. Over the same time period, the Shetland Platform, Norwegian Landmass and Mid‐North Sea High source regions are estimated to have supplied 2.3–5.6, 5.0–14.1, and 2.8–9.4 Mt/year of sediment, respectively, using the BQART sediment load model and independent geometrical reconstruction of eroded volumes, which are constrained by isostatic uplift estimates based on the geochemistry of syn‐depositional volcanic rocks. The net‐depositional sediment budget in the sink is an order‐of‐magnitude smaller than the total sediment budget supplied by the source regions (13.9–23 Mt/year). This discrepancy suggests that along‐shore transport by wave‐generated currents into the coeval Faroe‐Shetland Basin and/or down‐dip transport by gravity flows into the coeval western Møre Basin played a key role in redistributing sediments away from the Brent Delta system.
Emotional symptoms and cognitive function outcomes of subthalamic stimulation in Parkinson's disease depend on location of active contacts and the volume of tissue activated
Authors: Liang Kun , Li Ren‐Peng , Gao Yuan , Liu Chong , Wang Qiao , Gao Dong‐Mei , Wang Hui‐Min , Zou Liang‐Ying , Zhang Xin , Han Chun‐Lei , Zhang Jian‐Guo , Meng Fan‐Gang 
Published: March 2023

AbstractBackgroundSubthalamic nucleus (STN) deep brain stimulation (DBS) is an effective treatment for Parkinson's disease (PD), that can improve patients' motor and non‐motor symptoms. However, there are differences in the improvement of patients' emotional symptoms and cognitive function.ObjectiveTo investigate the impact of active contact location and the volume of tissue activated (VTA) on patients' emotional symptoms and cognitive function in STN‐DBS in PD.MethodsA total of 185 PD patients were included in this study. We evaluated them using the Movement Disorder Society‐Unified Parkinson's Disease Rating Scale, Hamilton Anxiety Scale (HAM‐A), Hamilton Depression Scale (HAM‐D), Montreal Cognitive Assessment (MoCA), and Mini‐Mental State Examination (MMSE) scales at the preoperative, 1‐ and 12‐month postoperative time points. Leads were positioned in standard space using the Lead‐DBS toolbox, and VTA was calculated for analysis.ResultsWhen the lead active contact was closer to the ventral side of the STN, the patients' HAM‐A improvement rate was higher, and when the active contact was closer to the anterior and dorsal sides of the STN, the patients' MoCA improvement rate was higher. Stimulation of the sensorimotor zone was more favorable to the improvement of HAM‐A and HAM‐D in patients. And, the stimulation of the associative zone was more favorable to the improvement of MoCA in patients.ConclusionOur results provide evidence that the 12‐month outcomes of cognitive function and emotional symptoms in PD patients with STN‐DBS were closely related to the specific location of the active contacts in the STN and influenced by the VTA.
Surgical treatment of stomal prolapse: A systematic review and meta‐analysis of the literature
Authors: Garoufalia Zoe , Mavrantonis Sofoklis , Emile Sameh Hany , Gefen Rachel , Horesh Nir , Freund Michael R. , Wexner Steven D. 
Published: March 2023

AbstractAimThis study aimed to assess success, recurrence, and overall complication rates among different surgical procedures for stomal prolapse.MethodsThis study was a PRISMA‐compliant systematic review. PubMed, Scopus, and Google Scholar were searched until March 2022. Studies that assessed surgical treatments of stomal prolapse in adults were included. The primary outcome was recurrence of stomal prolapse and the secondary outcome was 30‐day complications. A random‐effect meta‐analysis was used to estimate the weighted mean rates of recurrence.ResultsSix studies published (111 patients; 103 males) were included. 52 (46.8%) patients had end colostomies, 35 (31.5%) had loop colostomies. Seven procedures were assessed and included local stoma reconstruction (40%), stapled local repair (27%), modified Altemeier technique (10%), mesh strip repair (9%), stoma relocation (6%) redo laparotomy repair (5%), and colectomy and end ileostomy (3%). The weighted mean recurrence rate after local stoma reconstruction was 37.2% (95% CI: −1.8 to 76.3), higher than that after the stapled local repair technique (14.9%; 95% CI: 1.7–28.2). The crude recurrence rate of the modified Altemeier technique was 20%, and of stoma relocation was 66.6%. No recurrence was detected after the mesh strip technique (n = 10). The median follow‐up ranged between 7 months and 2.5 years.ConclusionSeveral surgical techniques are available to treat stomal prolapse. Local stoma reconstruction may be associated with high rates of recurrence while the stapled local repair and modified Altemeier procedure has relatively low recurrence. Further larger studies are needed to compare the efficacy of these techniques.
The roles of polymer relaxation phenomena, aqueous dye solubility and the physical properties of water in the mechanism of adsorption of a disperse dye on poly(ethylene terephthalate) fibres: part 5 analysis of polymer relaxation phenomena for different polymers
Authors: Burkinshaw S. M. , Liu K. 
Published: March 2023

AbstractThe temperature dependent uptake of a commercial disperse dye on cotton and polyamide 66 fabrics at dyeing temperatures between 30°C and 130°C adhered to the Williams–Landel–Ferry equation, insofar as, very good correspondence was observed between plots of experimentally determined colour strength data points (log1/fk) and the respective structural relaxation times of the cellulose and nylon 66 polymers (logaT data points), as a function of the parameter (T − Tg). Adsorption of the dye on both types of fibre therefore concurs with the fundamental precept of the free volume model of dye diffusion. Comparison of the adherence of the uptake of the commercial dye on cotton and polyamide 66 fabrics with that secured on polyester fabric revealed that despite the major chemical and physical differences between the three types of fibre, the same dyeing mechanism likely applies to each fibre type. The marked temperature dependent uptake of the commercial grade disperse dye each of the three types of substrate is the consequence of two, different, but inherently interconnected, thermally activated phenomena, namely the relaxation times of the molecular rearrangements occurring within the respective cellulose, nylon 66 or poly(ethylene terephthalate) macromolecule, in which polymer glass transition assumes the principal role, and the aqueous solubility of the commercial grade disperse dye.
Assessing translocation success and long‐distance homing in riverine turtles 10 years after a freshwater oil spill
Authors: Otten Joshua G. , Williams Lisa , Refsnider Jeanine M. 
Published: March 2023

AbstractWildlife translocation is often used as a mitigation strategy for construction projects and other disturbances to habitat. In 2010, one of the largest freshwater oil spills in the United States occurred in the Kalamazoo River in Michigan, when over 3.2 million L of diluted bitumen crude oil impacted nearly 56 km of riverine habitat. During 2010 and 2011 cleanup efforts, 686 northern map turtles (Graptemys geographica) were captured from oil‐impacted stretches of the river, cleaned, rehabilitated, and translocated 2.5–84.3 km from their original capture location. The goal of this translocation effort was to release turtles within the same watershed, but away from ongoing cleanup operations, so individuals could potentially return to their original home range after it had been cleaned of oil and restored. In this study, we evaluated the success of translocation as an emergency mitigation strategy for freshwater turtles by quantifying recapture probability and homing by northern map turtles translocated varying distances from their home ranges. During subsequent years of survey up to 10 years post‐spill, 230 of the translocated turtles were recaptured, of which 104 exhibited homing by returning to their original home ranges. Turtles translocated to sites nearest their original capture location had a higher probability of recapture and homing than those translocated further away. Females had a higher probability of returning to original home ranges than males when translocated greater distances. In addition, four females and one male are known to have traveled >50 km between capture and release locations, which to our knowledge is the greatest travel distance recorded for any freshwater turtle species in the United States. Our results demonstrate that riverine turtles have considerable homing ability when displaced long distances, which has important implications for design and success of translocation projects.
Multi‐site interaction turnover in flea–mammal networks from four continents: Application of zeta diversity concept and multi‐site generalised dissimilarity modelling
Authors: Krasnov Boris R. , Khokhlova Irina S. , Kiefer Mathias S. , Kiefer Daniel , Lareschi Marcela , Matthee Sonja , Sanchez Juliana P. , Shenbrot Georgy I. , Stanko Michal , van der Mescht Luther 
Published: March 2023

Abstract
We studied patterns of changes in host–flea interactions measured as total turnover (TT) which can be partitioned into components, namely species turnover (ST), interaction rewiring (RW), and mixed turnover (MX) in networks from Europe, Asia, Africa, and South America, applying a multi‐site interaction turnover metric. We also searched for environmental drivers of TT and its components.
We asked whether (a) different components contribute differently to TT in rare versus common interactions (in terms of frequency of interaction occurrence); (b) relative roles of turnover components for rare and common interactions differ between continents; and (c) the environmental drivers of interaction turnover differ between turnover components, rare and common interactions, and/or continental networks.
Between‐network dissimilarity of interactions increased with an increase in the number of compared networks. Pure ST contributed the most to the turnover of rare interactions, whereas the turnover of common interactions was predominated by MX.
The effects of environmental factors, interaction richness, and spatial distance on TT and its components differed between continental networks, turnover components, and rare versus common interactions. Climate and vegetation exerted the strongest effects on (a) ST for rare (except Asia) and, to a lesser degree, common (South America) interactions, (b) RW for both rare and common interactions in Europe/Asia, and (c) MX for both rare and common interactions (except Africa). Interaction richness and spatial distance mainly influenced ST.
We conclude that the patterns of interaction turnover and its components were geographically invariant and did not depend on the identity of the interactors, whereas the drivers of the turnover differed between continental networks because of species‐specific responses to the environment.
Trajectories of the SARS‐CoV‐2 RNA load in patients with hematological malignancy
Authors: Mitsuyuki Satoshi , Nishikubo Masashi , Shimomura Yoshimitsu , Ohyama Yukie , Maruoka Hayato , Nasu Seiko , Kubo Tomoyo , Suzuki Yuta , Okada Naoki , Nakagawa Daishi , Kamijo Kimimori , Yamamoto Ryusuke , Nagai Yuya , Hiramoto Nobuhiro , Yoshioka Satoshi , Yonetani Noboru , Hasegawa Kohei , Kuroda Hirokazu , Hasuike Toshikazu , Doi Asako , Kondo Tadakazu , Ishikawa Takayuki 
Published: March 2023

AbstractObjectivesThe higher risk of prolonged viral shedding in coronavirus disease (COVID‐19) patients with hematological malignancies (HM) necessitates test‐based de‐isolation strategies. However, evidence to establish their appropriate isolation period is insufficient. This study investigated the factors affecting prolonged viral shedding and the requisite isolation period in these patients.MethodsWe retrospectively reviewed 14 COVID‐19 patients with HM between January and April 2022, who were subjected to our test‐based de‐isolation strategy, followed by analysis of the viral load trajectory. The viral loads of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) were evaluated using the cycle threshold (Ct) of the reverse‐transcription quantitative polymerase chain reaction. The trajectories were classified according to the time‐interval from COVID‐19 onset to the attainment of Ct values >30.ResultsThe median interval between onset and attainment of a Ct value >30 was 22 days. Five patients with mild or moderate COVID‐19 without intense treatment histories achieved Ct values >30 within 20 days. The other nine patients needed more than 20 days, including three patients who did not meet this criterion during the observation period.ConclusionsThe SARS‐CoV‐2 viral load trajectories in patients with HM can be stratified by treatment history for the underlying HM and severity of COVID‐19.
Response rates of extra‐nodal diffuse large B cell lymphoma to anti‐CD19‐CAR T cells: A real word retrospective multicenter study
Authors: Beyar Katz Ofrat , Perry Chava , Grisariu‐Greenzaid Sigal , Yehudai‐Ofir Dana , Luttwak Efrat , Avni Batia , Zuckerman Tsila , Sdayoor Inbal , Stepensky Polina , Ringelstein‐Harlev Shimrit , Bar‐On Yael , Libster Diana , Sharvit Liat , Amit Odelia , Greenbaum Uri , Gold Ronit , Herishanu Yair , Benyamini Noam , Avivi Irit , Ram Ron 
Published: March 2023

AbstractChimeric antigen receptor T‐cells (CAR‐T) are widely used for the treatment of relapsed/refractory diffuse large B cell lymphoma (DLBCL). The data for CAR‐T cell therapy in patients with extra‐nodal (EN) lymphoma is restricted. We included 126 consecutive patients with DLBCL treated with commercially available CAR‐T cells (tisagenlecleucel, n = 100, 79.4% and axicabtagene ciloleucel, n = 26, 20.6%). At lymphodepletion, 72 of 126 (57%) patients had EN disease, 42 of 126 (33%) patients had nodal disease (ND)‐only and 12 of 126 (10%) showed no disease assessed by PET‐CT. There were no significant differences in CAR‐T related toxicities and in the median Progression free survival (PFS) between EN patients and ND (10.76 [95% CI: 7.8–13.6] vs. 14.1 [95% CI: 10–18.1] months, p = .126). Similarly, median overall survival (OS) was not significantly different (15.36 [95% CI 12.5–18.2] vs. 18.4 [95% CI 14.8–22.1] months, p = .100). Subgroup analysis according to the number of EN involved sites showed that median PFS and OS were significantly higher in patients with <3 EN sites (12.3 months [95% CI 9–15.5] vs. 4.28 months [95% CI 0.6–7.9], p = .010) compared to patients with >2 EN sites, respectively (16.5 months [95% CI 13.4–19.6] vs. 8.7 months [95% CI 4.6–12.8], p = .05). In multivariate cox regression analysis, increased number sites of EN disease and high lactate dehydrogenase (LDH) at lymphodepletion negatively impacted PFS (p = .021 and <.001, respectively), while sex, type of product administered, age and performance status did not predict PFS and OS. Of note, all the patients with involvement of gastrointestinal tract (n = 9), urinary tract (n = 9), or pharynx (n = 3) at lymphodepletion, progressed or had an early relapse. In conclusions, patients with >2 EN sites at lymphodepletion have significantly worse clinical outcomes compared to patients with <3 EN sites. Patients with specific sites of EN disease may demonstrate grim prognosis.
Fatigue and health‐related quality of life in paroxysmal nocturnal haemoglobinuria: A post hoc analysis of the pegcetacoplan PEGASUS trial data
Authors: Panse Jens , Wilson Koo , Fishman Jesse , Wojciechowski Piotr , Wdowiak Marlena , Horneff Regina , Patriquin Christopher J. , Oliver Monika , Hakimi Zalmai 
Published: March 2023

AbstractObjectivesParoxysmal nocturnal haemoglobinuria (PNH) is a rare, non‐malignant haematological disorder associated with disabling fatigue and reduced health‐related quality of life. Post hoc analysis of PEGASUS phase 3 trial (NCT03500549) characterised improvements in patient‐reported fatigue measured by functional assessment of chronic illness therapy‐fatigue (FACIT‐fatigue) instrument item‐level ratings for pegcetacoplan and eculizumab for the treatment of PNH.MethodsItem‐level responder analysis was conducted on a ≥2‐level change from baseline (CFB) clinically important response (CIR) for the FACIT‐fatigue 13 individual items rated on a 5‐level Likert scale. We evaluated ≥2‐level change against the minimal clinically important difference (MCID) of the FACIT‐fatigue total score (≥5 points) and clinical parameters, haemoglobin (Hb; ≥1 g/dL) and normalised absolute reticulocyte count (ARC; 30–100 pg/cells). Logistic regressions estimated baseline‐to‐Week‐16 FACIT‐fatigue item‐level transitional probabilities; Kaplan–Meier analysis estimated time to FACIT‐fatigue item CIR.ResultsPegcetacoplan versus eculizumab was associated with significantly greater odds of Week 16 CIR across 8/13 items and on total score MCID (OR [CI] = 11.19 [3.73, 33.57]) and faster times to responses. The item‐level CIR threshold also showed clinical relevance on Hb level and ARC normalization.ConclusionsCompared with eculizumab, pegcetacoplan was associated with clinically meaningful greater improvements on a majority of FACIT‐fatigue items.
Quantification approaches for magnetic resonance imaging following intravenous gadolinium injection: A window into brain‐wide glymphatic function
Authors: Richmond Sutton B. , Rane Swati , Hanson Moriah R. , Albayram Mehmet , Iliff Jeffrey J. , Kernagis Dawn , Rosenberg Jens T. , Seidler Rachael D. 
Published: March 2023

AbstractThe glymphatic system is a brain‐wide network of perivascular pathways along which cerebrospinal fluid and interstitial fluid rapidly exchange, facilitating solute and waste clearance from the brain parenchyma. The characterization of this exchange process in humans has relied primarily upon serial magnetic resonance imaging following intrathecal gadolinium‐based contrast agent injection. However, less invasive approaches are needed. Here, we administered a gadolinium‐based contrast agent intravenously in eight healthy participants and acquired magnetic resonance imaging scans prior to and 30, 90, 180, and 360 min post contrast injection. Using a region‐of‐interest approach, we observed that peripheral tissues and blood vessels exhibited high enhancement at 30 min after contrast administration, likely reflecting vascular and peripheral interstitial distribution of the gadolinium‐based contrast agent. Ventricular, grey matter and white matter enhancement peaked at 90 min, declining thereafter. Using k‐means clustering, we identify distinct distribution volumes reflecting the leptomeningeal perivascular network, superficial grey matter and deep grey/white matter that exhibit a sequential enhancement pattern consistent with parenchymal contrast enhancement via the subarachnoid cerebrospinal fluid compartment. We also outline the importance of correcting for (otherwise automatic) autoscaling of signal intensities, which could potentially lead to misinterpretation of gadolinium‐based contrast agent distribution kinetics. In summary, we visualize and quantify delayed tissue enhancement following intravenous administration of gadolinium‐based contrast agent in healthy human participants.
Disadvantage and neurocognitive comorbidities in childhood idiopathic epilepsies
Authors: Schraegle William A. , Slomowitz Rebecca F. , Gundlach Carson , Hsu David A. , Almane Dace N. , Stafstrom Carl E. , Seidenberg Michael , Jones Jana E. , Hermann Bruce P. 
Published: March 2023

AbstractObjectiveThis study was undertaken to characterize the relationship between neighborhood disadvantage and cognitive function as well as clinical, sociodemographic, and family factors in children with new onset idiopathic epilepsy and healthy controls.MethodsResearch participants were 288 children aged 8–18 years with recent onset epilepsy (CWE; n = 182; mean age = 12.2 3.2 years), healthy first‐degree cousin controls (HC; n = 106; mean age = 12.53.0), and one biological or adopted parent per child (n = 279). All participants were administered a comprehensive neuropsychological battery (reasoning, language, memory, executive function, motor function, and academic achievement). Family residential addresses were entered into the Neighborhood Atlas to determine each family's Area Deprivation Index (ADI), a metric used to quantify income, education, employment, and housing quality. A combination of parametric and nonparametric (χ2) tests examined the effect of ADI by group (epilepsy and controls) across cognitive, academic, clinical, and family factors.ResultsDisadvantage (ADI) was equally distributed between groups (p = .63). For CWE, high disadvantage was associated with lower overall intellectual quotient (IQ; p = .04), visual naming/expressive language (p = .03), phonemic (letter) fluency (p < .01), passive inattention (omission errors; p = .03), delayed verbal recall (p = .04), and dominant fine motor dexterity and speed (p < .01). Cognitive status of the HC group did not differ by level of disadvantage (p = .40). CWE exhibited greater academic difficulties in comparison to HC (p < .001), which were exacerbated by disadvantage in CWE (p = .02) but not HC (p < .05). High disadvantage was associated with a threefold risk for academic challenges prior to epilepsy onset (odds ratio = 3.31, p = .024).SignificanceSocioeconomic hardship (increased neighborhood disadvantage) exerts a significant adverse impact on the cognitive and academic status of youth with new and recent onset epilepsies, an impact that needs to be incorporated into etiological models of the neurobehavioral comorbidities of epilepsy.