bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyps and colorectal cancer in serrated polyposis syndrome: contribution of the classical adenoma-carcinoma and serrated neoplasia pathways
Authors: van Toledo David E.F.W.M. , IJspeert Joep E.G. , Boersma Hannah , Musler Alex R. , Bleijenberg Arne G.C , Dekker Evelien , van Noesel Carel J.M. 
Published: June 2023

Abstract

Introduction
Patients with serrated polyposis syndrome (SPS) have an increased risk to develop colorectal cancer (CRC). Due to an abundance of serrated polyps (SPs), these CRCs are assumed to arise mainly through the serrated neoplasia pathway rather than through the classical adenoma-carcinoma pathway. We aimed to evaluate the pathogenetic routes of CRCs in SPS patients.

Methods
We collected endoscopy and pathology data on CRCs and polyps of SPS patients under treatment in our center. Our primary endpoint was the proportion of BRAF

V600E
mutated-CRCs, indicating serrated-pathway CRCs (sCRCs). CRCs lacking BRAF

V600E
most likely inferred a classical adenoma-carcinoma origin (aCRCs). We assessed patient, polyp and CRC characteristics and stratified for BRAF

V600E
mutation status.

Results
Thirty-five SPS patients harboured a total of 43 CRCs. Twenty-one CRCs (48.8%) carried a BRAF

V600E-mutation, 10 of which lacked MLH1 straining and 17 (81%) were located in the proximal colon. Twenty-two CRCs (51.1%) did not carry a BRAF

V600E
-mutation and were MLH1 proficient. Of these 22 putatively aCRCs, 17 (77.3%) were located distally and one-third (36.4%) harboured a pathogenic KRAS or NRAS mutation. In patients with BRAF

wt
-CRCs a higher ratio of the median number of conventional adenomas versus SPs was found (3.5vs12.5) than patients with BRAF

V600E
-sCRCs (1vs14).

Conclusion
Our study indicates that in SPS patients the ratio of sCRCs:aCRCs on average is fifty:fifty. This elevated sCRC:aCRC ratio in SPS patients, as compared to non-SPS patients, correlates well with the differences in the ratios of the numbers of sessile serrated lesions and conventional adenomas in SPS and non-SPS patients respectively.
Unraveling pathophysiologic mechanisms contributing to symptoms in patients with post‐acute sequelae of COVID‐19 (PASC): A retrospective study
Authors: Dierckx Wendel , De Backer Wilfried , Ides Kris , De Meyer Yinka , Lauwers Eline , Franck Erik , De Backer Jan 
Published: June 2023

AbstractPatients with post‐acute sequelae of COVID‐19 (PASC) present with a decrease in physical fitness. The aim of this paper is to reveal the relations between the remaining symptoms, blood volume distribution, exercise tolerance, static and dynamic lung volumes, and overall functioning. Patients with PASC were retrospectively studied. Pulmonary function tests (PFT), 6‐minute walk test (6MWT), and cardiopulmonary exercise test were performed. Chest CT was taken and quantified. Patients were divided into two groups: minor functional limitations (MFL) and severe functional limitations (SFL) based on the completed Post‐COVID‐19 Functional Status scale (PCFS). Twenty one patients (3 M; 18 FM), mean age 44 (IQR 21) were studied. Eighteen completed the PCFS (8 MFL; 10 SFL). VO2max was suboptimal in both groups (not significant). 6MWT was significantly higher in MFL‐group (p = 0.043). Subjects with SFL, had significant lower TLC (p = 0.029). The MFL‐group had more air trapping (p = 0.036). Throughout the sample, air trapping correlated significantly with residual volume (RV) in L (p < 0.001). An increase in air trapping was related to an increase in BV5 (p < 0.001). Mean BV5 was 65% (IQR 5%). BV5% in patients with PASC was higher than in patients with acute COVID‐19 infection. This increase in BV5% in patients with PASC is thought to be driven by the air trapping in the lobes. This study reveals that symptoms are more driven by occlusion of the small airways. Patients with more physical complaints have significantly lower TLC. All subjects encounter physical limitations as indicated by suboptimal VO2max. Treatment should focus on opening or re‐opening of small airways by recruiting alveoli.
Evaluation of blood pressure response during dobutamine stress echocardiography in patients without cardiovascular diseases
Authors: Bigdelu Leila , Mahmoudi Meimand Reza , Azadi Nadia , Jarahi Lida , Ghaderi Yoones , Baradaran Rahimi Vafa 
Published: June 2023

AbstractDobutamine stress echocardiography (DSE) is a diagnostic tool for determining coronary artery disease. Considering hypotension and hypertension as important complications of DSE, we aimed to evaluate the blood pressure (BP) responses during DSE. Patients without known cardiovascular diseases who underwent DSE were included. We excluded patients who had hypertension, diabetes mellitus, a known history of cardiovascular diseases, and those taking vasoactive medications. Systolic (SBP) and diastolic (DBP) blood pressure were recorded at baseline and peak stress. We included 688 patients with an age of 57.9 ± 12.01 years. During DSE, SBP (+19.72 ± 26.51 mm Hg, p < 0.001), DBP (+5.52 ± 17.35 mm Hg, p < 0.001), and HR (+54.05 ± 22.45 bpm, p < 0.001) significantly increased from baseline to peak stress. The normal cut‐off value was measured between 101–210 mm Hg for SBP and 50–121 mm Hg for DBP. According to this normal cutoff, 11 (1.3%) and 30 (4.4%) patients had hypotensive and hypertensive SBP and 15 (2.2%) and 21 (3.1%) patients had hypotensive and hypertensive DBP, respectively. The hypotensive response was correlated with baseline SBP (r = 0.6, p = 0.001) and atropine (r = −2.18, p = 0.043), and the hypertensive response was correlated with baseline SBP (r = 0.048, p < 0.001). Baseline BP and atropine consumption were the independent variables associated with the outside‐the‐normal range of blood pressure responses.
Schelling’s Clara: Romantic Psychotherapy
Authors: Vater Michael 
Published: June 2023

Abstract
Schelling’s unfinished novella/dialog from the early years of his turn to philosophy of spirit presents arguments for personal immortality, but in a narrative form. Characters that represent nature and mind try to rescue the usually equanimous Clara from psychological crisis occasioned by her husband’s death and consequent intellectual perplexities about personal survival. Their arguments illustrate Schelling’s reformulated Spinozistic metaphysics: expressivism. On this theory, a Wesenheit or creative essence manifests in both physical and psychic dimensions but is itself nothing other than the connection between the two. Clara, doctor, and pastor symbolize these three functions while their personae fashion arguments that psychic and somatic phenomena can never be separated, hence that death must signify a transformation into a more spiritual psychosomatic mode of being. The arguments are problematic at best, but the narrative invokes Romantic tropes such as the limits of conceptual language, the possibility of a natural style of communicating philosophy, and reference to then contemporary ‘empirical’ phenomena such as clairvoyance and hypnotic sleep. The unfinished character of the piece reinforces the impression of ineluctability of the self, which seems to exist only in diaspora as nostalgia or anticipation.
B R Ambedkar’s Multiple Consciousness and the Framing of the Indian Constitution
Authors: Gadkar-Wilcox Sujata 
Published: June 2023

Abstract
This article will analyze the way in which B R Ambedkar's lived experience and jurisprudential commitments framed the discursive structure of the Indian Constitution and reformulated prevailing conceptions of liberal constitutionalism to reflect the specific and historically contingent context in which it was formed. Whereas prevailing notions of political rights in Western liberalism were conceived as abstract protections of individuals against the state, Ambedkar attempted to reframe the idea of rights as including correlative duties and accounting for material conditions of inequality and systemic discrimination. Heblurred the distinction between the higher-order law and everyday politics, and conceptualized rights as horizontal in addition to vertical in character. Finally, he included a temporal reorientation of the liberal constitutional paradigm by incorporating permissive constitutional structures. This article analyzes his approach to constitutional jurisprudence within the framework of Mari Matsuda’s notion of multiple consciousness.
The Role of the Road in Settling a Mountainous Region
Authors: Miňo Martin 
Published: June 2023

Abstract
Although fertile soil is rare in central Slovakia, the region is rich in raw minerals, a resource exploited since the Palaeolithic. Maintaining trade through a reliable network of safe routes across the mountainous landscape was of vital importance, and the remains of roads that connected this mining area to the rest of the world can still be found. Furthermore, the south–north route connecting these resources with the Carpathian Basin in the south and the Vistula River Basin in the north may have played an important role as a possible bypass to the well-known Amber Road. By combining walkthrough surveys and high-resolution LiDAR data, the paths of single roads can be reconstructed and analysed in relation to the main routes. Furthermore, by applying the geographic information system-based spatial context of settlement structures, analyses can be performed on whether routes passing through certain areas caused the establishment of settlements or whether the routes were built to connect the established sites with the rest of the road network. Finally, defining ancient route planning strategies can help answer the question of how the main routes affect settlement patterns.
Applicability of fractal models for characterising pore structure of hybrid basalt–polypropylene fibre-reinforced concrete
Authors: Liu Bo , Li Dan , Fu Qiang , He Lu , Mai Tianrui 
Published: June 2023

Abstract
The pore-structure characteristics of hybrid basalt–polypropylene fibre-reinforced concrete were investigated by using mercury intrusion porosimetry. The applicability of various fractal models in characterising the HBPRC pore structure was compared. The results show that the types and content of fibres show different influences on the cumulative pore volume and fractal characteristics of hybrid basalt-polypropylene fibre-reinforced concrete. Compared with pore-volume and solid mass, the fractal characteristics of pore surface area of hybrid basalt-polypropylene fibre-reinforced concrete is more significant. Furthermore, the pore-surface fractal model that established based on the energy conservation relationship during mercury intrusion is more accurate and effective for the characterization of fractal dimension of hybrid basalt-polypropylene fibre-reinforced concrete. The research results can provide important theoretical guidance for the study of pore structure and fractal characteristics of fibre-reinforced concrete.
The Effect of Rest Redistribution on Kinetic and Kinematic Variables During the Countermovement Shrug
Authors: Meechan David , McMahon John J. , Suchomel Timothy J. , Comfort Paul 
Published: June 2023

Abstract
Meechan, D, McMahon, JJ, Suchomel, TJ, and Comfort, P. The effect of rest redistribution on kinetic and kinematic variables during the countermovement shrug. J Strength Cond Res 37(7): 1358–1366, 2023—This study compared the effects of rest redistribution (RR) on kinetic and kinematic variables during the countermovement shrug (CMS). Twenty-one male subjects (age 27.2 ± 3.3. years, height 1.78 ± 0.07 m, body mass 77.2 ± 10.6 kg, relative 1 repetition maximum (1RM) power clean [PC] 1.22 ± 0.16 kg·kg−1) performed the CMS using 140% of 1RM PC with 3 traditional sets of 6 repetitions (TS), 9 sets of 2 repetitions with RR [45 s rest after 2 repetitions] (RR45), and 6 sets of 3 repetitions with RR [72 s rest after 3 repetitions] (RR72). There were no significant or meaningful differences (p > 0.05, g = 0.00–0.15) between set configurations for any variables for the average of the 18 repetitions. There were no significant (p > 0.05) or meaningful (g = 0.00–0.14) differences for configuration and configuration × set for peak (PF) and mean force (MF), peak velocity (PV), impulse, phase duration, peak velocity decline, peak velocity maintenance, and rating of perceived exertion. There was significantly greater (p = 0.034) albeit small (g = 0.15) difference for mean velocity (MV) during TS compared with RR72. There were no significant or meaningful differences (p > 0.05, g = 0.00–0.09) between sets for PF, MF, PV, MV, impulse, and duration across TS, RR45, and RR72. Rest redistribution protocols did not result in greater kinetics or kinematics during the CMS compared with TS, when total rest time was equated. Thus, shorter more frequent rest periods during the CMS may not be required to maintain force-time characteristics.
Acute Effects of High-Load vs. Plyometric Conditioning Activity on Jumping Performance and the Muscle-Tendon Mechanical Properties
Authors: Krzysztofik Michał , Wilk Michał , Pisz Anna , Kolinger Dominik , Bichowska Marta , Zajac Adam , Stastny Petr 
Published: June 2023

Abstract
Krzysztofik, M, Wilk, M, Pisz, A, Kolinger, D, Bichowska, M, Zajac, A, and Stastny, P. Acute effects of high-load versus plyometric conditioning activity on jumping performance and the muscle-tendon mechanical properties. J Strength Cond Res 37(7): 1397–1403, 2023—The effectiveness of high-load and plyometric exercises as conditioning activity (CA) is not well described in the level of performance enhancement and muscle-tendon properties. Therefore, this study aimed to compare the effectiveness of high-loaded back squats and body mass tuck jumps among amateur soccer players on the height of countermovement jump performed without (CMJ) and with arm swing (CMJa) and to verify the usefulness of the myotonometry in assessing the level of CA-induced fatigue. Therefore, 16 male amateur soccer players (resistance training experience: 2 ± 1 year, relative 1 repetition maximum back squat strength: 1.41 ± 0.12 kg·body mass−1) performed 3 experimental sessions to compare the acute effects of 3 sets of 3 repetitions at 85% one repetition maximum of half back squats (HL), 3 sets of 5 repetitions of tuck jump exercises (PLY), and no CA (CTRL) on CMJ and CMJa height. Moreover, the gastrocnemius medialis and Achilles tendon tone and stiffness were examined. Measurements were performed 5 minutes before CA and in the third, sixth, and ninth minutes after CA. The CMJ height significantly increased from pre-CA to post-CA in the CTRL (p = 0.005; effect size [ES] = 0.36; Δ = +3.4%) and PLY (p = 0.001; ES = 0.83; Δ = +8.8%) conditions. Moreover, post-CA jump height was significantly higher in PLY than in the HL condition (p = 0.024; ES = 0.6; Δ = +5.9%). No significant differences were found for CMJa height, tone, and stiffness of gastrocnemius medialis and Achilles tendon. The low-volume plyometric CA (i.e., 3 sets of 5 repetitions) is recommended instead of high-loaded CA (≥85% one repetition maximum) for amateur athletes. In addition, it has been established that the performance improvement was independent of changes in the mechanical properties of the gastrocnemius medialis and Achilles tendon. Furthermore, it seems that the complexity of the post-CA task may affect the magnitude of the postactivation performance enhancement.
The Effects of Adolescents' Perceived Handwashing Attitudes, Health Beliefs, and Internal Control on Handwashing Practices in the COVID-19 Pandemic Situation
Authors: Oh Jae Woo , Song Ji-Ah 
Published: June 2023

This study aims to provide basic data for developing a hand washing education program to prevent infection by identifying the factors that affect hand washing practice for high school students who need to establish healthy lifestyles in the COVID-19 outbreak situation. Data collection was conducted from December 10 to 31, 2020 for 149 in high school students. The collected data were analyzed using the SPSS 20.0 program. As a result, internal control(p<.05) and hand washing attitude(p<.05) had a significant effect on dependent variables. the result of this study indicates that the internal control means a tendency to attribute the cause or effect of an action to internal factors, such as ability, attitude, and effort of one’s own, educational plans that can increase the hand washing practice rate by cultivating a positive hand washing attitude and improving internal control through education on the importance of personal quarantine should be prepared.
Ultrasound-Assisted Lumbar Puncture in Children: A Meta-Analysis
Authors: Kuitunen Ilari , Renko Marjo 
Published: June 2023

CONTEXT
Success rates of lumbar puncture are rather low in children. Ultrasound guidance has been suggested to increase success rate.

OBJECTIVE
To systematically compare lumbar puncture success with and without ultrasound in children.

DATA SOURCES
PubMed, Scopus, and Web of Science databases were searched in January 2023.

STUDY SELECTION
Randomized controlled trials including children (aged &lt;18 years) and comparing ultrasound-assisted lumbar puncture to palpation-marked lumbar puncture were included.

DATA EXTRACTION
One author extracted, and the other author validated data.

RESULTS
Seven studies were included. First puncture success rate was 71.7% (190 of 265) in the ultrasound group and 58.9% (155 of 263) in the palpation group (risk ratio [RR], 1.22; (confidence interval [CI], 1.00–1.50; 5 studies). First puncture success rate with ultrasound was higher in infants (RR, 1.41; CI, 1.10–1.80; 3 studies), but not in older children (RR, 1.07; CI, 0.98–1.17; 2 studies). Overall success rate was 89.3% (276 of 309) in the ultrasound group and 80.3% (248 of 309) in the palpation group (RR, 1.11; CI 0.95–1.30; 7 studies).

LIMITATIONS
Evidence quality was rated low because of risk of bias (3 studies high risk of bias) and imprecision.

CONCLUSIONS
Ultrasound use may improve first puncture success rate in infants but not in older children. We did not find evidence of difference in overall success rate. Better quality evidence is needed before implementing ultrasound guidance in practice.
O prazer da leitura: perspectivas de abordagem no CEFET-PB
Authors: Formiga Girlene Marques 
Published: June 2023

O presente estudo apresenta uma visão geral acerca da relação leitura-escola, evidenciando ainda o importante papel da família em relação ao despertar para o gosto da leitura nas crianças. Á escola cabe complementar e aprofundar as vivências de leitura já trazidas pelo aluno, através de estratégias que despertem o prazer de ler, conforme discute esta pesquisa, que se presta também a oferecer sugestões que possam nortear uma abordagem mais dinâmica no que se refere ao trabalho com a leitura em sala de aula.<p> </p>
Prospecção Tecnológica de Soluções aplicada a Emergências de Saúde Pública: uma análise das Feiras de Soluções para a Saúde
Authors: Santos Rezende Kellen , De Souza Rocha Correia Cinthya Vivianne , De Oliveira Silva Gabriela , De Jesus Martins Wagner 
Published: June 2023

Objetivos: Com este estudo, buscou-se apresentar a metodologia de aplicação da intervenção do programa Feiras de Soluções para a Saúde, desenvolvida pela Fundação Oswaldo Cruz (Fiocruz), para a prospecção de tecnologias e pesquisa translacional de soluções industriais, sociais e de serviços; e analisar os principais resultados agregados com a proposição de melhorias. Métodos: estudo qualitativo, descritivo, dividido em quatro etapas: 1) descrição da metodologia desenvolvida e aplicada pela Fiocruz para o programa; 2) análise dos resultados extraídos do banco de dados das soluções apresentadas nas feiras e avaliação prospectiva das soluções industriais quanto ao nível de maturidade tecnológica; 3) sistematização dos resultados de uma pesquisa de opinião realizada com atores que apresentaram soluções em uma das quatro feiras; e 4) elaboração de uma matriz contendo os aspectos positivos e melhorias identificadas para etapas futuras das feiras. Resultados: As Feiras realizadas na Bahia (2017), Rio Grande do Sul e Ceará (2019) e a Feira Virtual (2020) permitiram a agregação rápida de soluções desenvolvidas pela sociedade nos contextos das emergências de saúde pública de zika e da doença causada pelo novo coronavírus (Coronavirus Disease 2019 - COVID-19) e na busca dos Objetivos do Desenvolvimento Sustentável. Conclusões: A realização das feiras tem mobilizado milhares de pessoas, envolvendo os principais atores para o enfrentamento de ameaças à saúde, desenvolvimento de economia solidária no nível local e com reflexos extraterritoriais. Verifica-se a consolidação da metodologia aplicada pela Fiocruz e considera-se efetiva a participação dos cidadãos, gestores, pesquisadores e empresários.
The Comparative Evaluation of Hospitalized Elderly Patients with COVID-19 from the Onset of the Disease to Recovery and Death in Iran
Authors: Barati Barat , Kaydani Masoumeh , Ahmadpour Fatemeh , Kalantar Mojtaba , Birgani Fariba Farhadi 
Published: June 2023

Background & Objectives: Numerous studies have shown that the risk of death is higher in elderly patients with COVID-19. In Iran, due to the growth of the elderly population and the prevalence of underlying diseases, it is necessary to pay attention to this age group of patients. In this study, clinical, radiological, PCR, and laboratory data of elderly patients with COVID-19 were collected and analyzed in two groups of recovered and dead patients.Materials & Methods: This is a retrospective study of 196 consecutive elderly patients with COVID-19 hospitalized from March 21, 2020, to April 3, 2020, and their follow-up until April 23, 2021. Clinical characteristics, laboratory results, PCR, chest CT scans and Hounsfield Unit data were collected and analyzed in two groups of recovered and dead patients. Obtained Data were analyzed using SPSSv22.0 and MATLAB-R2017 software.Results: The results showed that there were no specific symptoms to distinguish the death group from the recovery group. Significant differences were observed between the two groups for red blood cell counts, hemoglobin, MCHC and MCV levels, bilirubin, aminotransferase levels, CRP, white blood cells, serum BNU, creatinine and PT coagulation index. The concentrations of VBG (HCO3) and VBG (PCO2) in the deceased patients suggest compensated respiratory alkalosis. CT sensitivity is 100% for patients in advanced and severe stages of the disease.Conclusion: The patients in the death group had more underlying diseases than the recovered group. COVID-19 patients are more likely to die when they have both diabetes and cardiovascular disease.