bluuebunny/crossref_metadata_2025_split huggingface dataset:
The dynamic tumor-stromal crosstalk: Implications of ‘stromal-hot’ tumors in the process of Epithelial-Mesenchymal Transition
Authors: Mavatkar Apoorva D , Naidu Chandrakala M , Prabhu Jyothi S , Nair Madhumathy G 
Published: January 2023

Abstract
Breast cancer metastatic programming involves an intricate process by which the tumor cell co-evolves with surrounding extracellular niche. The supporting cells from the local host stroma get morphed into cancer associated stromal cells. This complex crosstalk leads to extracellular matrix re-fabrication, invasion, and eventually distant metastasis. In this review, we examine the protein-miRNA secretome that is crucial for this crosstalk. We also attempt to delineate the persuasive role of the stroma in mediating epithelial to mesenchymal transition. We elucidate an in-depth appraisal of the might of the stromal niche that can yield promising diagnostic markers and pave avenue for new connexions that may aid in formulating tailored anti-cancer therapy.
First molecular biologically confirmed case of Dirofilaria repens in a dog in Denmark
Authors: Jensen Asger Lundorff , Krogh Anne Kirstine Havnsøe , Lundsgaard Jo Fjeldsted-Holm , Willesen Jakob Lundgren , Lyngby Janne Graarup-Hansen , Schrøder Anders Simon , Bach Maiken Bayer Thode , Berg Rebecca P.K.D. 
Published: January 2023

Abstract

Dirofilariasis is spreading among dogs and humans in Europe with infections being established in many countries. In Denmark, at least one to two generations of Dirofilaria spp. can occur per year. Here, we describe the first molecular biologically confirmed case of D. repens infection in a dog in Denmark.
Impact-abrasive wear resistance of high alumina ceramics and ZTA
Authors: Varga Markus , Grundtner Reinhard , Maj Matthias , Tatzgern Fabio , Alessio Karl-Otto 
Published: January 2023

Abstract

In transport of raw materials abrasive wear resistance is a requirement, which can be met with alumina ceramics. At certain locations additional impact load occurs, exacerbating the wear loss. As literature on impact-abrasive wear of ceramics is scarce this topic will be researched in this work. We selected a variety of commercial alumina ceramics (90-96% Al2O3) and according to literature much more impact resistant – and substantially more expensive – Zirconia Toughened Alumina (ZTA, 20- 25% Zr) used for wear resistant linings in impact dominated systems. We selected the Impeller-Tumbler test, an impact-abrasion test for wear evaluation of highly loaded ceramic edges. Two load regimes were evaluated for the abrasive, either corundum particles for severe load or steel for extreme load conditions. Correlation of wear results with the fracture toughness (K1C) and Vickers hardness of the materials is intended – material parameters used as measure for brittle failure of ceramics and wear resistance, respectively. The various ceramic materials showed very different wear behaviour under the impact-abrasive load. The 90% Al2O3 was least wear resistant under both load conditions. Interestingly large differences between the 92% types were found at extreme load conditions. The increase of alumina content to 95- 96% showed remarkable benefits in both wear regimes. Best wear resistance against severe load was achieved by 25% ZTA, while it is comparable to the 95-96% high alumina types at extreme load.
WITHDRAWN: Design and control of a mobile robot following the desired Trajectory using an adaptive sliding mode approach
Authors: LIU YONGQIU , Zhong Shaohui , MUSTAFA KAINAT , Aslam Sheraz , Daraz Amil 
Published: January 2023

Abstract
This paper presents a design for a control system that will ensure the stability and proper operation of a mobile four-wheeled robot. As a result of the nonlinear dynamics, structural and parametric uncertainty of this robot, various control approaches are used to achieve stability and proper performance and minimize modeling errors and uncertainties. Two control approaches are applied to ensure that this robot is stable, that its performance is appropriate, and that modeling errors and uncertainties are minimized. In the presence of external disturbances and parametric uncertainty, this algorithm uses the signals provided by the sensor from the trajectory to follow the predetermined trajectory. It was assumed in previous articles that the upper bound of uncertainty was known. In this paper, we assume the upper bound of uncertainty and disturbance in the robotic system is unknown since, in many cases, we cannot know the extent of these uncertainties. In this paper, we generalized the sliding mode control law and proved its effectiveness so that by including an adaptive part to the control law, we make it into a robust-adaptive sliding mode control, and we could estimate the upper bound uncertainties online based on these adaptive laws. The control objective is to follow a predefined trajectory by regulating the linear and angular velocities in the presence of external disturbance and parametric uncertainty. The Adaptive Super Twisting (AST) algorithm is designed to build a robust controller with neglected chattering in a steady state. The proposed controller is validated experimentally. The results show that the proposed controller guarantees the performance of the conventional SOSMC under external disturbance and parametric uncertainty with less chattering. This typology can be expressed as a distinct theorem with stable results. Simulations with MATLAB software demonstrate that the controller ensures optimal performance under external disturbances and parametric uncertainty with fewer fluctuations.
The Teaching of Listening for EFL Students: An Overview
Authors: Putri Erawati Wiyono 
Published: January 2023

Methods and techniques used by both ESL and EFL students in listening may be the same but the manner of teaching should be different. For instance, ESL students can learn to listen outside the class by using authentic material as listening to the conversation of a librarian in the library (real situation) while EFL students can also do that by listening to the video provided by the teacher which performs a conversation between native speakers in a library. The students should exercise their listening skills more in order to improve their level of mastery of listening. Students better not only do exercise in listening class but also in other places. Students must be confident in their own answers to be better in listening class and can know their own mistakes.
Drug-Eluting Stent Restenosis: Modern Approach to a Classic Challenge
Authors: Donisan Teodora , Madanat Luai , Balanescu Dinu V. , Mertens Amy , Dixon Simon 
Published: January 2023

Abstract:In-stent restenosis (ISR) is a recognized complication following percutaneous coronary intervention in which the luminal diameter is narrowed through neointimal hyperplasia and vessel remodeling. Although rates of ISR have decreased in most recent years owing to newer generation drug-eluting stents, thinner struts, and better intravascular imaging modalities, ISR remains a prevalent dilemma that proves to be challenging to manage. Several factors have been proposed to contribute to ISR formation, including mechanical stent characteristics, technical factors during the coronary intervention, and biological aspects of drug-eluting stents. Presentation of ISR can range from asymptomatic to late myocardial infarction and could be difficult to differentiate from acute thrombus formation. No definite guidelines are present on the management of ISR. In this review, we will discuss the mechanisms underlying ISR and provide insight into patient-related and procedural risk factors contributing to ISR, in addition to highlighting common treatment approaches utilized in the management of ISR.
Immunomodulatory Effects of Agarwood Leaf Extract on RAW264.7
Murine Macrophages
Authors: Nirwana Soelaiman Ima , Pang Kok-Lun , Chin Kok-Yong 
Published: January 2023

Background:
The immunomodulatory effects of plants have been utilised to
enhance the immunity of humans against infections. However, evidence of such effects of
agarwood leaves is very limited despite the long tradition of consuming the leaves as tea.

Objective:
This study aimed to investigate the immuno-modulatory effects of agarwood
leaf extract (ALE) derived from Aquilaria malaccensis using RAW264.7 murine macrophages.

Methods:
In this study, RAW264.7 macrophages were incubated with ALE alone for 26
hours or ALE for 2 hours, followed by bacterial lipopolysaccharide for 24 hours. The nitrite
and cytokine production (tumour necrosis factor-alpha (TNFα), interleukin (IL)-1β, IL-6,
and IL-10), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX2) expression
in the macrophages were assayed.

Results:
The study showed that ALE alone was immunostimulatory on the macrophages
by increasing the nitrite, TNFα, and IL-6 production and COX2 expression (p<0.05 vs.
untreated unstimulated cells). Pre-treatment of ALE suppressed nitrite level and iNOS expression
but enhanced TNFα and IL-6 production and COX2 expression (p<0.05 vs. untreated
lipopolysaccharides (LPS)-stimulated cells). ALE also increased IL-10 production
regardless of LPS stimulation (p<0.05 vs. untreated cells).

Conclusion:
ALE was able to promote the immune response of macrophages by upregulating
pro-inflammatory cytokine levels and COX2 expression. It also regulated the extent
of the inflammation by reducing iNOS expression and increasing IL-10 levels. Thus, ALE
may have a role in enhancing the innate immune system against infection; however, its
validation from in vivo studies is still pending.
Chrysin Effect Against Gastric Cancer: Focus on its Molecular Mechanisms
Authors: Samarghandian Saeed , Alavi Dana Seyyed Mohammad Matin , Farkhondeh Tahereh , Aschner Michael , Darroudi Majid , Samini Helia 
Published: January 2023

Abstract:
Gastric cancer is one of the most prevalent cancers in the world. Various therapeutic
modalities have been used for its treatment, but all exhibit severe side effects, establishing
the need for novel approaches. Chrysin is a phytomedicine compound belonging
to the flavonoid group. It is found in honey and many plants. Its antitumor effects
have been documented against gastric cancer cell lines in vitro, establishing its effects are
mediated via different pathways and the expression of miRNA. In this review, we summarize
the available literature on chrysin and its effects on gastric cancer, focusing on the
cellular mechanisms it targets.
Rancang Bangun Pengendali Suhu pada Fermentasi Kefir Berbasis Kontroler PI
Authors: Rahmadwati Rahmadwati , Habibi Boby Yusuf 
Published: January 2023

Kefir merupakan susu fermentasi yang memiliki rasa, warna, dan konsistensi yang menyerupai yogurt dan memiliki aroma khas yeasty. Kefir memiliki kandungan gula susu (laktosa) yang relatif rendah dibandingkan susu murni dan cocok bagi penderita lactose intolerant atau tidak tahan terhadap laktosa. Fermentasi bahan pangan adalah hasil kegiatan dari beberapa spesies mikroba seperti bakteri, khamir dan kapang. Mikroba fermentasi mendatangkan hasil akhir yang dikehendaki. Proses fermentasi kefir berlangsung pada suhu 25-37Â°C. Pada umumnya fermentasi kefir masih dibuat dengan menggunakan proses manual dengan hanya meletakkannya di suatu tempat tertutup tanpa tahu berapa suhu yang ada pada proses tersebut.Â Sehingga tidak jarang sebagian masyarakat mengalami kegagalan dalam proses pembuatannya. Pada penelitian ini dilakukan pengontrolan suhu berbasis Arduino Uno dengan kontroler PI pada box fermentasi kefir. Kontroler PI dipilih karena karakteristik respon yang diinginkan adalah respon yang cepat dan memiliki nilai error yang kecil. Â Aktuator berupa elemen pemanas (heater) dan sensor suhu DS18B20 sebagai feedback system.Â Proses perancangan kontroler PI menggunakan metode Ziegler-Nichols yang pertama dan didapatkan parameter kontroler PI dengan gain yaitu Kp = 26,45 dan Ki = 0,61. Nilai setpoint 32â„ƒ. Pada pengujian keseluruhan sistem tanpa gangguan didapatkan performansi respon settling time (ts) sebesar 954 s atau 15,9 menit dan error sebesar 0,593%. Pada pengujian keseluruhan sistem dengan gangguan didapatkan performansi respon settling time (ts) sebesar 960 s atau 16 menit, error sebesar 0,593% dan recovery time sebesar 165 s atau 2,75 menit.
Aplikasi Solar Tracker System Berbasis Arduino Uno untuk Sistem Photovoltaic Pada Penerangan Jalan Umum
Authors: Wibawa Unggul , Purnomo Hery , Ramadhani Ahmad Zaki 
Published: January 2023

Penelitian ini membahas tentang perbandingan keluaran daya antara panel surya konvensional dengan panel surya yang menggunakan sistemÂ pelacak sinarÂ matahari (solar tracker system). Pada penelitian iniÂ juga membahas bagaimana rancangan sistem fotovoltaik yang akan digunakan untuk mencatu lampu penerangan jalan umum dengan menggunakan lampu LED DC sebesar 5 watt dan rancangan sistem alat pelacak sinar matahari yang berbasis Arduino uno. Perbandingan yang dilakukan adalah dengan mengukur arus dan tegangan keluaran kedua buah panel surya dimana satu panel surya konvensional dan satu panel surya menggunakan sistem pelacak sinar matahari. Pengujian dilakukan dalam dua kondisi yaitu pada kondisi cuaca cerah dan pada kondisi cuaca mendung. Pada cuaca cerah rata- rata selisih efisiensi antara panel surya yang menggunakan sistem pelacak sinar matahari dengan panel surya konvensional adalah sebesar 1,12% dan pada kondisi cuaca mendung adalah sebesar 1,94%. Hasil pengujian menunjukkan bahwa panel surya yang menggunakan sistem pelacak sinar matahari memiliki tingkat efisiensi daya yang lebih tinggi dari pada panel surya konvensional.
Aplikasi Metode Per Connection Queue Pada Optimasi Bandwidth Pada Jaringan Internet
Authors: Priyono Wahyu Adi , Setiawati Chofifah Rahmatullaili 
Published: January 2023

Kualitas jaringan merupakan suatu faktor penentu kenyamanan pengguna dalam melakukan aktivitas jaringan komputer. Pada suatu jaringan komputer diperlukan suatu pengaturan bandwidth agar tidak terjadi monopoli penggunaan bandwidth. Manajemen bandwidth dapat dilakukan menggunakan mikrotik routerboard RB941-2nd dengan aplikasi pengaturan mikrotik menggunakan WinBox. Implementasi manajemen bandwidth menggunakan metode PCQ (Per Connection Queue) dengan teknik antrian simple queue dan queue tree. Untuk mengamati performansi kualitas jaringan menggunakan Network Analyzer Wireshark pada saat masing-masing PC melakukan video conference. Hasil implementasi manajemen bandwidth ini mampu diterapkan dengan baik pada kedua teknik antrian dan memiliki nilai yang baik pada masing-masing parameter jaringan. Maka dari hasil keempat nilai parameter jaringan, didapatkan nilai yang paling baik menurut kategori TIPHON dengan indeks 4 (Sangat Bagus) adalah pada teknik antrian Queue Tree yaitu dengan hasil rata-rata Packet Loss pada video conference Google Meet sebesar 0,38962857% dan pada Zoom sebesar 1,021288%. Hasil rata-rata DelayÂ pada video conference Zoom sebesar 1,389343 ms dan pada Google Meet sebesar 1,860071 ms. Hasil rata-rata Jitter pada video conference Google Meet sebesar 1,50059 x 10-21 ms dan pada Zoom sebesar 3,0065 x 10-21.Hasil rata-rata Throughput pada video conference Zoom sebesar 22,64215 Mbps dan pada Google Meet sebesar 12,94397 Mbps. Lamanya durasi, jenis teknik antrian, jenis video conference, dan kualitas jaringan juga mempengaruhi hasil dari QoS (Quality of Service).
Comparison of vitamin D intake and ultraviolet light exposure in pre and postmenopausal women in the elderly pandemic period
Authors: Syahrial Syahrial , Resmiati Resmiati , Nindrea Ricvan Dana , Hanum Faiz Nur 
Published: January 2023

<p><strong><em>Background: </em></strong><em>Osteoporosis is one of the degenerative diseases in the elderly which is still a priority health problem in Indonesia. There are several precautions that can be taken to prevent the occurrence of osteoporosis, one of that is vitamin D. Vitamin D can be obtained through exposure to Ultraviolet (UV) rays from the sun and from nutritional sources of food. Vitamin D can slow down the process of osteoporosis, because vitamin D is able to maintain bone health by increasing the absorption of the mineral calcium.</em><em></em></p><p><em> </em></p><p><strong><em>Objectives: </em></strong><em>The purpose of this study is to see the comparison of vitamin D intake and UV exposure in pre and postmenopausal women during the pandemic.</em></p><p><strong><em>Methods: </em></strong><em>This research was an analytic study conducted with a cross sectional research design, which compares predictor variables and outcome variables that are viewed simultaneously. The study was conducted on women aged 35-65 years at the Elderly Posyandu, Padang City. Then the results of the data obtained will be analyzed using the Anova test.</em><em></em></p><p><strong><em>Results: </em></strong><em>The results showed that the percentage of menopausal respondents exposed to UV light was higher (87.5%) compared to those who were not exposed to UV light (12.5%). Then the percentage of menopausal respondents based on the consumption of Vit D &lt; RDA was higher (52.5%) than the consumption of Vit D &gt; RDA (47.5%).</em><em></em></p><strong><em>Conclusions: </em></strong><em>There was no significant difference (p&lt;0.05) between the incidence of menopause and levels of vitamin D intake (p=0.381) and UV light exposure (p=0.462) in the elderly at the Posyandu Lansia, Padang City</em>
Characteristics and Influencing Factors of Social Isolation in Patients with Breast Cancer: A Latent Profile Analysis (Preprint)
Authors: He Chunyan , Wu Chao , He Yang , Yan Jiaran , Lin Yawei , Wan Yi , Xue Shuzhi , Gao Fangning , Chang Wei , Liu Rongrong , Yang Tianqi , Lang Hongjuan , Cao Baohua 
Published: January 2023

BACKGROUND

With the improvement of the survival rate of patients with breast cancer (BC) , the problem of social isolation (SI) began to attract public attention，However, few studies explore the internal heterogeneity of SI and ignore the heterogeneity among patient groups at different levels.

OBJECTIVE

The goal of this study is to investigate the SI subtypes of patients with BC and to explore the influencing factors of it.

METHODS

A sample of 303 BC patients participated in the study from September to December, 2021. Latent profile analysis (LPA) was performed to identify SI clusters based on the three sub-scales of the Chinese version of the Social Anxiety Scale, the Chinese version of the Social Avoidance and Distress Scale, and the Chinese version of the Loneliness Scale.

RESULTS

We found that SI can be divided into three categories: high-level (Class 1), middle-level (Class 2), and low-level (Class 3), accounting for 20.46%, 33.00%, and 46.54%, respectively. Compared to Class 3, Class 1, which had the lower average monthly income per family member (RMB) (< 3000: OR = 5.298, P = .021; 3000~5000: OR = 5.320, P = .018), was more likely to suffer from SI due to occupation (Laborer: OR = 12.023, P = .009). Surgery (OR = 14.138, P < .001; OR = 2.777, P = .020), chemotherapy (OR = 10.224, P = .001; OR = 3.545, P = .001); poorer family functioning (OR = .671, P < .001; OR = .801, P = .002), and lower levels of self-transcendence (OR = .806, P < .001; OR = .911, P <.001) were important influencing factors for SI in Class 1 and Class 2 compared to Class 3.

CONCLUSIONS

SI is classifiably heterogeneous among patients with BC. Strategies that identify characteristics of SI and give targeted intervention focusing on family functioning and improving self-transcendence levels contribute to the prevention of SI among patients with BC.
Pembuatan Hand Sanitizer Non-Alkohol dari Ekstrak Daun Sirih sebagai Solusi Adanya Sensivitas Kulit terhadap Alkohol
Authors: Putri Arisa  , Nurhayati  
Published: January 2023

Abstract: Corona virus is a new type of virus that can cause symptoms such as MERS-CoV and SARS-CoV. Covid-19 transmission can occur through a splash from the mouth or nose of an infected person with Covid-19. The risk of covid-19 transmission is increasing and the public is required to be ready to stop the spread and transmission of covid-19. The existence of prevention to prevent the increase of the corona virus is very necessary, one of which is the use of hand sanitizers as a public health protocol. This study used the main ingredients of betel leaf and lime leaf extracts. Betel leaf contains saponins, flavonoids, polyphenols and essential oils which function as antimicrobials. Hand sanitizer made from betel leaf and lime leaf extract is a relatively safe hand sanitizer and can be used as a solution for people who are sensitive to alcohol. Making hand sanitizers using natural ingredients, namely betel and lime leaf extracts is very practical and does not cost a fortune. 15% betel leaf extract is as effective as alcohol.
Keywords: Covid-19; Hand Sanitizer; Betel leaf; Lime
Compilation of Islamic Law as Judge's Consideration at a Religious Court in North Sulawesi, Indonesia
Authors: Bilalu Naskur , Jamal Ridwan , Harun Nurlaila , Subeitan Syahrul Mubarak 
Published: January 2023

This study examines the Compilation of Islamic Law (KHI) as a consideration for Religious Court Judges in North Sulawesi in resolving legal cases. This paper is empirical legal research using the sociology of law approach based on facts related to the considerations of judges and decisions of the religious courts in North Sulawesi as the application of the Compilation of Islamic Law. The data collection technique is based on literature review, especially court decisions and in-depth interviews with judges. The findings show that there are four forms of application of KHI, namely: First, KHI is the main reference with considerations: 1) if there is no basis for legal considerations in Laws and Government Regulations; 2) KHI is the agreement of the ulema and is a series of written laws; 3) KHI is jurisprudence, Second, KHI is a reinforcement reference to Government Laws and Regulations with the following considerations: 1) KHI is a reaffirmation of Government Laws and Regulations; 2) KHI provides Islamic characteristics and values; 3) KHI is a special provision for Muslims; 4) KHI realizes marriages must be carried out based on the provisions of the law of religion and belief. Third, KHI is a special reference with the considerations: 1) KHI regulates specifically, while it is not found in laws and Government Regulations; 2) KHI is a special reference for Religious Courts; 3) KHI has regulated while the laws and regulations have not regulated, and Fourth, KHI is not a reference at all with the consideration that no legal basis is found.