bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occult appendix pathology in patients undergoing colorectal cancer resection: is there a role for incidental appendectomy?
Authors: Fabio Francesco , Ravi Prabhu , Allievi Niccolo , Khan Kashuf A , Abduelraheim Abu , Moran Brendan 
Published: June 2023

Abstract
Purpose
The risk to benefit balance of incidental appendectomy in patients undergoing left colorectal cancer resection is unclear. The aim is to assess the proportion of histologically abnormal appendices in patients undergoing colorectal cancer resection in a unit where standard of care is appendectomy, with consent, when left-sided resection is performed.
Methods
Retrospective study on prospectively collected database, conducted in a single tertiary-care centre. Overall, 717 consecutive patients undergoing colorectal cancer resection between January 2015 and June 2021 were analysed. The primary outcome was the proportion of histologically abnormal appendix specimens at incidental appendectomy. Secondary outcome was complications from incidental appendectomy.
Results
Overall, 576/717(80%) patients had appendectomy at colorectal cancer surgery. In total, 234/576(41%) had a right-/extended-right hemicolectomy or sub-total colectomy which incorporates appendectomy, and 342/576(59%) had left-sided resection (left-hemicolectomy, anterior resection or abdomino-perineal excision) with incidental appendectomy.
At definitive histology, 534/576(92.7%) had a normal appendix. The remaining 42/576(7.3%) showed abnormal findings, including: 14/576(2.4%) inflammatory appendix pathology, 2/576(0.3%) endometriosis, 8/576(1.4%) hyperplastic polyp, and 18/576(3.1%) appendix tumours, which encompassed 6 low-grade appendiceal mucinous neoplasms (LAMN), 3 carcinoids and 9 serrated polyps.
In the 342 patients who had incidental appendectomy, 10(2.9%) had a neoplasm (2 LAMN, 3 carcinoids and 5 serrated polyps). There were no complications attributable to appendectomy.
Conclusion
Patients undergoing left sided colorectal cancer surgery with an appendix in situ may benefit from a co-incidental appendectomy to treat the small proportion of synchronous neoplasms and eradicate the risk of metachronous appendicitis or a subsequent appendix tumour.
Existence results for a hybrid system of mixed differential equations with sequential fractional derivatives
Authors: SARIKAYA Mehmet Zeki , Benmehidi Hammou , DAHMANI Zoubir 
Published: June 2023

Abstract
In this paper, we are interested in studying a hybrid system of sequential type by applying the Caputo and Hadamard fractional derivatives, using the fixed point principle, we establish new result for the existence and uniqueness of solutions. Another result is established by using Schaefer's fixed point theorem. At the end, an example is given.
2020 Mathematics Subject Classification. 30C45, 39B72, 39B85.
Hybrid Multi-Response Optimization and Analysis of UFSW Process Using Entropy Measurement: Effect of Tool Deviation on mechanical properties of an optimum joint
Authors: BOUKRAA Moustafa , Chekifi Tawfiq , MADANI Tahar , AISSANI Mouloud , BENMALAK Toufik , SETTAR Abdelhakim , LEBAAL Nadir 
Published: June 2023

Abstract
This study focuses on enhancing weld joints of AA2017 aluminum alloys obtained through the UFSW (Underwater Friction Stir Welding) process. An integrated method utilizing Grey relational entropy measurement as a multi-response optimization tool was employed. The objective was to improve the performance of the weld joint by optimizing the process parameters, including advanced speed, tool rotation speed, and forging force, to enhance tensile strength, elongation, and microhardness. The L9 orthogonal design with three factors and three levels was utilized, and subsequent analysis of variance and confirmation tests were conducted. Furthermore, the influence of lateral deviation of the welding tool on the mechanical properties and microstructural characteristics of the optimal joint was investigated. Experimental results aligned well with the outcomes predicted by the proposed mathematical model, affirming the effectiveness of the optimization method. Notably, the study demonstrated an increase in weld joint efficiency from 68.55–93% through the implementation of the optimization approach. The welding tool deviation ranging from − 1.5 mm to 1.5 mm showed that the tensile strength of the optimal joint decreases while the strain rate increases when the offset was on the advancing side (AS).
Biological treatment of nitrocellulose: investigation on structural and thermodynamic properties
Authors: Huang Juan , Zhang Alei , Xue Huihui , Zhou Jie , Ding Yajun , Xiao Zhongliang 
Published: June 2023

Abstract
Biological method is a sustainable method for various waste polymers treatment due to green, low-cost, mild condition and simple operation. In this study, a novel biological method to process nitrocellulose (NC) to obtain NC with low nitrogen via nitrate ester removal using fungal Chaetomium elatum was proposed. With the extension of time (6 d), the N% of NC declined continuously from 13.06% to 11.71%. Structure properties were investigated by Fourier-transform infrared spectroscopy (FTIR), and Laser Raman co-focal microspectrometry (Raman), which showed the intensity of energetical groups (O-NO2, -NO2) decreased. Most importantly, the thermal decomposition properties were performed using Thermogravimetric analysis (TG) and Differential scanning calorimetry (DSC) analysis, where the kinetic parameters of thermal decomposition reaction with DSC were calculated by three traditional methods: Friedman-Reich-Levi, Flynn-Wall-Ozawa and Kissinger-Akahira-Sunose. It indicated that the weight-loss ratio of bio-treated NC decreased from 86.33% to 66.20% and the activation energy (Ea) increased first and then reduced as the increase of denitrification time, which demonstrating thermostability of bio-treated NC was enhanced. Hence, this structure exploration and thermodynamic analysis provide new method for further investigation of the mechanism of the biological denitrification process and the assessment safety of bio-treated NC.
Productive viral infections in oligotrophic marine waters
Authors: Varona Natascha , Hesketh-Best Poppy , Stiffler Alexandra , Garcia Sofia , Scholten Yun , Haas Andreas , Little Mark , Coutinho Felipe Hernandes , Vermeij Mark , Luque Antoni , Silveira Cynthia 
Published: June 2023

Abstract
Viral lysis of dominant bacterial groups is accepted as the main mechanism through which viruses impact marine microbial communities. However, the structure of virus-bacteria infection networks and the abundance of their members have yet to be empirically characterized in situ. Here, we tackled this problem by building the virus-bacteria infection network of an oligotrophic environment using proximity-ligation, prophage integration, and CRISPR spacers. This network of 1388 previously undescribed virus-host pairs was integrated with community rank-abundance curves using direct counts of bacteria and viruses to identify productive viral infections. The same dominant viruses remained abundant across samples, but productive infections were poorly explained by viral and host abundances. This suggests that slow turnover rates maintain the abundance top-ranked, while viruses with medium-to-low abundances infecting heterotrophs are more productive. We predict that these non-dominant viruses contribute significantly more to biogeochemical cycling and host ecology due to their high turnover rates.
Mixed effects models for large-sized clustered extremes
Authors: Momoki Koki , Yoshida Takuma 
Published: June 2023

Abstract
Extreme value theory (EVT) provides an elegant mathematical tool for statistical analysis of rare events. Typically, when data are collected from multiple clusters, analysts want to preserve cluster information, such as region, period, and group. To consider large-sized cluster information in extreme value analysis, we incorporate the mixed effects model (MEM) into the regression technique in EVT. In the field of small area estimation, it is well known that the MEM is an important tool for providing reliable estimates of large-sized clusters with small sample sizes. In the context of EVT for rare event analysis, the sample size of extreme value data for each cluster is often small. Therefore, the MEM may contribute to improving the predictive accuracy of extreme value analysis. This motivates us to verify the effectiveness of the MEM in EVT through theoretical studies and numerical experiments, including its application to the risk assessment of heavy rainfall in Japan.
MSC Classification: 62F12 , 62H11 , 62J05
Integration of aberrant alternative splicing events and RNA binding proteins revealed their potential regulation in diabetic foot ulcers
Authors: Wang Mengyan , hao Qingzhi , Ma Ruiping , qin hongsong , luo ailing 
Published: June 2023

Abstract
Background
Diabetic foot ulcer (DFU) is one of the most serious complications of diabetes and the main cause of non-traumatic amputation in diabetic patients. Disruption of alternative splicing (AS) and RNA binding proteins (RBPs) has been proven to cause a variety of diseases, including DFU. But the regulatory network of RBPs-AS and its underlying functions in DFU remain unclear.
Methods
Whole transcriptome data of ulceration tissues were analyzed to identify dysregulated AS and RBPs, comprising ulceration tissues from thirteen DFU patients (seven patients with healed ulcers and six patients with unhealed ulcers, the DFU group) and eight normal samples (the control group). We identified the differentially expressed genes (DEGs), regulated alternative splicing events (RASEs), and changes in immune infiltration between DFU and control tissues. Finally, co-expression analysis was performed to establish the regulatory network of RBPs-AS-immune infiltration in DFU tissues.
Results
DEG analysis showed that 4478 and 4514 genes were differentially expressed in healed and unhealed DFU tissues, respectively. Gene functional analysis showed that many DEGs were enriched in immune and inflammatory pathways. Many RASEs were identified between unhealed DFU and control tissues. Functional analysis showed that genes with RASEs were primarily enriched in apoptosis pathways. According to immune infiltration analysis, the percentage of memory B cells and activated mast cells were higher in the DFU group than in the control group. According to the co-expression analysis, the ratio values of RASEs in apoptosis-associated genes were related to the percentage of infiltrated immune cells in DFU tissues. In addition, the co-expression network showed that differentially expressed RBPs (DE RBPs) could regulate the RASEs and affect the immune infiltration in DFU tissues. Finally, we found that the aberrant expressions of DCN, HSP90AA1, SMAD7, YWHAG, YWHAZ, KPNA2, S100A16, and DUSP14 would affect the AS of FAT1, COL12A1, UPP1, EIF5A and AKAP13 in DFU tissues.
Conclusion
Our results showed that DE RBPs may play a role in wound healing in DFU by regulating the AS of pre-mRNAs, especially immune inflammation- and apoptosis-related pre-mRNAs, and may continue to play a role in DFU regardless of the healing state.
Dispersal differences and determined factors of invasive alien plants along roadside in three habitats, Encheng national nature reserve, China
Authors: Dai Wanting , Guo Chaodan , Li Junsheng , Zhao Caiyun 
Published: June 2023

Abstract
Invasive alien plants cause major losses to native biodiversity. Nature reserves are crucial in resisting invasion, but resistance varies by habitats. To explore the variations and factors that determine invasive alien plant dispersal patterns in different habitats, we investigated abandoned land, eucalyptus plantations, and natural secondary forests in Encheng National Nature Reserve, Guangxi. Our results showed a significant decrease in invasive alien plants with increasing distance from roads in secondary forest, while there was no significant trend in the two other habitats. No significant trends were observed in the distribution of invasive alien plants within the soil seed bank in the three habitats perpendicular to the road direction. Invasive alien plant composition varied with the distance from the road and was found to be similar both aboveground and in the soil seed bank. Factors influencing invasive species composition at different road edges differed by habitats, abandoned land was affected by average human flow, average traffic flow, and distance to the village, eucalyptus plantations by pH, average human flow, native herb richness of soil seed bank, and road width, and secondary forest by road width, road grade, and native herb richness and density. Our results indicated that the secondary forest resists plant invasion better than eucalyptus plantations and abandoned land, moreover, native herbs play important roles in resisting invasive species in both secondary forest and eucalyptus plantations. To target invasive alien plants in nature reserves, prioritize the abandoned land and plantation forests based on our findings.
Prolonged preoperative sedentary time is a risk factor for postoperative ileus in patients with colorectal cancer: a propensity score-matched retrospective study
Authors: Yanagisawa Takuya , Tatematsu Noriatsu , Horiuchi Mioko , Migitaka Saki , Yasuda Shotaro , Itatsu Keita , Kubota Tomoyuki , Sugiura Hideshi 
Published: June 2023

Abstract
Purpose
This study aimed to investigate the association between prolonged preoperative sedentary time (ST) and postoperative ileus (POI) after adjusting for confounders in patients with colorectal cancer (CRC).
Methods
This single-center retrospective study enrolled 155 consecutive patients who underwent surgery for primary CRC. A diagnosis of POI was made by the surgeons if the Clavien-Dindo classification (CD) grade is ≥ 2 within 30 days after surgery. Preoperative ST was assessed using the International Physical Activity Questionnaire usual week short version (Japanese version). Patients were classified into two groups (ST < 6 h/day and ST ≥ 6 h/day) based on results from the questionnaire, and data were analyzed using a propensity score-matching strategy to adjust for confounders. In addition, receiver operating characteristic (ROC) curve analysis was performed to identify the optimal cutoff value of preoperative ST for predicting POI.
Results
Of the 155 patients, 134 were included in the analysis. POI occurred in 16 (11.9%) patients of overall patients and 11 (12.5%) of the 88 matched patients. The logistic regression analysis after propensity score-matching showed that prolonged preoperative ST (ST ≥ 6 h/day) was associated with POI (odds ratio 5.40 [95% confidence interval: 1.09 − 26.60], p = 0.038). The ROC curve analysis indicated that the optimal cutoff value of preoperative ST for predicting POI was 6 h/day.
Conclusion
Prolonged preoperative ST is a risk factor for POI in patients with CRC. Therefore, reducing preoperative ST may play an important role in preventing POI.
Replacement of Dietary Fish Protein With Bacterial Single Cell Protein Results in Decreased Adiposity Coupled With Liver Expression Changes in Female Danio Rerio
Authors: williams michael , GREEN GEORGE B.H. , PALMER JOSEPH W. , FAY CHRISTIAN X. , CHEHADE SOPHIE B. , LAWRENCE ADDISON L , BARRY ROBERT J. , POWELL MICKIE L. , HARRIS MELISSA L. , WATTS STEPHEN A. 
Published: June 2023

Abstract
Background
Effective use of Danio rerio as a preclinical model requires standardization of macronutrient sources to achieve scientific reproducibility across studies and labs. Our objective was to evaluate single cell protein (SCP) for production of open-source standardized diets with defined heath characteristics for the zebrafish research community. We completed a 16-week feeding trial using juvenile D. rerio 31 days post-fertilization (dpf) (10 tanks per diet, 14 D. rerio per tank) with formulated diets containing either a typical fish protein ingredient or a novel bacterial SCP source. At the end of the feeding trial, growth metrics, body composition, reproductive success, and bulk transcriptomics of the liver (RNAseq on female D. rerio only with confirmatory rtPCR) were performed for each diet treatment.
Results
D. rerio fed the SCP containing diet had body weight gains equivalent to the D. rerio fed fish protein, and females had significantly lower total carcass lipid, indicating reduced adiposity. Reproductive success was similar between treatments. Genes differentially expressed in female D. rerio provided the bacterial SCP compared to females given fish protein were overrepresented in the gene ontologies of metabolism, biosynthesis of cholesterol precursors and products, and protein unfolding responses.
Conclusion
These data support the development of an open-source diet utilizing an ingredient that correlates with improved health profiles and reduced variability in notable outcomes.
Portal Vein Thrombosis after Cetuximab and 5-Fluorouracil Therapy in a Patient with Advanced Colon Cancer and Decompensated Cirrhosis: A Case Report and Review of the Literature
Authors: Liu Fangyu , Xu Yongmei , Yang Guowang , Guo Yuhong , Nian Jiayun 
Published: June 2023

Abstract
Background Treatment options for advanced colon cancer are mainly combinations of chemotherapy and targeted drugs. However, poor physical health and medication intolerance limit the choice of anticancer drugs. Colon cancer with cirrhosisis a particular patient group that poses a challenge to clinical treatment.
Case presentation This article presents a case of a patient in the decompensated stage of cirrhosis who was diagnosed with advanced colon cancer. The initial presentation was a nodule on his navel named the Sister Mary Joseph’s nodule, which was later confirmed by biopsy and PET-CT as one of the metastases of colon cancer. The patient was treated with Cetuximab and 5-Fluorouracil at a below-guideline dose, however, portal vein thrombosis developed and led to death. This entire process, from diagnosis to death, occurred within a span of three months.
Conclusion Cancers with cirrhosis are a special group that deserves more attention. There is no unified treatment guideline for these patients, especially those with extrahepatic primary tumors. We should be more cautious when choosing treatment for such patients in the future. Both chemotherapy and targeting may potentially induce portal vein thrombosis, which appears to have a higher incidence and worse prognosis than other diseases.
Flood Hazard Zonation Using Gis-based Multi-parametric Analytical Hierarchy Process
Authors: Ahmed Istak , (Pan) Nibedita Das , Debnath Jatan , Bhowmik Moujuri , Bhattacharjee Shaswati 
Published: June 2023

Abstract
Flood is considered to be a serious environmental hazard, owing to its devastating consequence on human life. Tripura, a small state of northeast India has faced large scale flood events over the last few decades. The present study is an attempt to identify flood hazard zones along the lower course of the Dhalai River flowing through the Dhalai district of Tripura. An integrated approach of remote sensing and GIS coupled together with Analytical Hierarchy Process (AHP) was applied to identify the flood hazard zones of the study area and nine parameters were selected for this purpose. Thematic maps of the parameters were reclassified after assigning ranks to different classes. A pair-wise comparison matrix among all the parameters was prepared using AHP to determine the relative weight of each parameter. Finally, flood hazard zonation map of the study area was prepared using raster calculator of Arc GIS 10.1. The results revealed that 109.69 km2 (27.65%) of the study area fall under low flood risk category. At the same time, around 114.46 km2 (28.85%) and 90.43 km2 (22.80%) areas fall under moderate and high flood risk zone respectively. The study also disclosed that the high risk zone has maximum concentration of agricultural land (68.63%) and settled area (9.77%) in comparison to the other two zones which has increased vulnerability of flood hazard. The information derived from the present study could be very much effective for the planners to prepare proper strategies to reduce the vulnerability of flood hazard in the study area.
Source effects determine hydrochorous seed dispersal of ancient forest plants
Authors: Boedeltje Ger , Lenssen John P.M. , Braak Cajo J.F. , Zuidam Bastiaan 
Published: June 2023

Abstract
Plant species of ancient forests tend to be poor dispersers, although field studies suggest that dispersal may be strongly accelerated in streams. To further test this idea we addressed the following two questions: 1) which traits facilitate transport and deposition of seeds by streams? 2) do ancient forest species differ from other forest species with respect to these traits? In the BovenSlinge, a forested lowland stream in the Netherlands we measured water transport and deposition and analysed which traits best explained this. We subsequently compared ancient forest species with other forest species with respect to these key traits. Our field measurements indicated that stream dispersal is strongly determined by both source related traits, i.e. upstream population size, seed production and seed release period and the path related variables buoyancy and seed weight. These traits seemed to affect transport and deposition similarly, but seed mass had a much stronger, negative impact on deposition. Ancient forest species do not differ with respect to seed release period, buoyancy and seed mass, but at a given plant height, ancient forest species produce less seeds than other forest species. This may reflect an adaptation to their relatively stable habitat which comes at the expense of (stream) dispersal capacity. In conclusion, ancient forest plants are just as well equipped for stream dispersal as other forest species, but success will critically depend on upstream population size, given their low per plant seed production.
Investigating the Effectiveness of Interpretable Cost-Sensitive Neural Network for Pneumonia Detection Contemplating Data Imbalance
Authors: Maliyat Ramisa , Sultana Fatema , Sultana Sadia , Joy Sajib Kumar Saha , Shawon Md Tanvir Rouf 
Published: June 2023

Abstract
Pneumonia is a bacterial or viral respiratory ailment that affects a lot of people, especially in impoverished and newly industrialized countries due to pollution, unclean living conditions, and overcrowding. The objective of this research focuses on developing an automated approach for correctly identifying pneumonia from X-rays of the chest images in order to decrease the time needed for manual evaluation. In the study, two imbalanced datasets—the Corona Hack Chest X-Ray dataset and the Chest X-ray Images dataset—were selected. Using the transfer learning models ResNet50, VGG16, and Inception Net, pneumonia has been effectively identified in chest X-ray images. These models help with the classification issues related to locating irregularities connected to pneumonia and classifying those X-rays into two distinct categories based on detection outcomes. In the Chest X-Ray Images dataset, Inceptionv3 achieved the highest accuracy of 97.43%, followed by VGG16 with 96.57% and ResNet50 had an accuracy of 96.40%. However, in the Corona Hack Chest X-Ray dataset, ResNet50 achieved the highest accuracy of 93.91%, followed by Inception-v3 with 91.04% and VGG16 with 90.03%. Notably, these models were created to recognize and divide into two groups of anomalies in chest X-rays related to pneumonia. For imbalanced chest X-ray image datasets, a cost-sensitive neural network outperformed ResNet50, VGG16, and Inception-v3 by 1%, 2%, and 0.51%, respectively. However, the cost-sensitive neural network performed best for the Corona Hack Chest X-Ray dataset, outperforming the standard VGG16 and Inception-v3 models by 3% and 1%, respectively.