bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iodine Status in Pregnant Women Having Urinary Fluoride in Contaminated Areas: A Case Study of Phayao Province
Authors: Somporn Rattawan , Lapinee Chaipat , Umponstira Chanin , Weterings Robbie , Chaiwong Sanhawat 
Published: January 2023

Fluoride naturally occurs in the Earth’s crust and is widely dispersed in groundwater. The high consumption of fluoride can inhibit iodine metabolism in the human body, especially in the thyroid gland. This study assessed iodine knowledge, iodine consumption behavior, urinary iodine (UI), thyroid stimulating hormone (serum TSH), and free triiodothyronine3 (serum FT3) and examined the connection between fluoride exposure and UI and thyroid function as serum concentrations of TSH and FT3 in pregnant women dwelling in an area of endemic fluorosis. This was a cross-sectional study. The population included 152 pregnant women within the 1st trimester of pregnancy, during which they were provided antenatal care (ANC) in seven public community hospitals in Phayao province, Thailand. The study consisted of two components. First, the study consisted of a questionnaire in which we evaluated the iodine knowledge and iodine consumptive behaviors in subjects. Second, biochemical data were investigated to evaluate thyroid function in the subjects. The gestational age of most subjects was 8–12 weeks. The study population has lived in fluoride-contaminated areas since birth (76.97%). The iodine and iodine consumption levels were moderate (50.00%). Their food iodine consumption was 3–4 days/week, and the top five consumption ranks were iodized salt, cooked pork, eggs, sticky rice, and iodine fish sauce. In terms of biochemical parameters, 63.16% of respondents had UI levels below 150.00 g/L, which is below the normal reference range of 150.00–249.00 g/L. 89.47% of the risk of hypothyroidism was associated with serum TSH levels below 2.50 g/L. In 38.16% of the samples, normal levels of serum FT3 (2.00–4.40 pg/L) were identified in the subjects. In addition, 61.84% of the samples had FT3 concentrations greater than 4.40 pg/L (high intake of iodine). The approved association between positive serum FT3 data and serum TSH was positive (r = 260 and

p

< 0.05). These studies imply that these elevated levels of TSH and FT3 place pregnant women in their first trimester at risk for hypothyroidism.
NPY Methylated ctDNA is a Promising Biomarker for Treatment Response Monitoring in Metastatic Colorectal Cancer
Authors: Janssens Katleen , Vanhoutte Greetje , Lybaert Willem , Demey Wim , Decaestecker Jochen , Hendrickx Koen , Rezaei Kalantari Hassan , Zwaenepoel Karen , Pauwels Patrick , Fransen Erik , Op de Beeck Ken , Van Camp Guy , Rolfo Christian , Peeters Marc 
Published: January 2023

Abstract

Purpose:
Analysis of methylation markers in liquid biopsies is a promising technique for the follow-up of patients with metastatic colorectal cancer (mCRC), because they can be used in all patients, regardless of their mutational status. Therefore, we studied the value of NPY methylation analysis in circulating tumor DNA (ctDNA) for accurate response monitoring in patients with mCRC in the PANIB trial.

Experimental Design:
The PANIB trial was a randomized phase II trial designed to compare FOLFOX plus panitumumab and FOLFOX plus bevacizumab in patients with RAS wild-type unresectable mCRC. The results of sequential liquid biopsies were correlated with results of imaging.

Results:
Forty patients were included from six Belgian hospitals. Analysis of the liquid biopsies revealed that higher baseline levels of methylated ctDNA was associated with a significantly shorter overall survival [HR, 1.015; 95% confidence interval (CI), 1.005–1.025; P = 0.002]. Furthermore, 37 patients provided at least two liquid biopsies. Thirty-one of them showed a decrease in the methylation ratio after the start of therapy, which corresponded with stable disease or response on imaging at the first evaluation. When comparing the panitumumab and bevacizumab arm, significantly higher objective response and early tumor shrinkage rates were observed in the panitumumab arm (P = 0.048 and 0.015, respectively). However, due to a small study population, the trial was underpowered to detect a significant difference in survival.

Conclusions:
The results of this study confirm that baseline methylated ctDNA is a prognostic marker and indicate that NPY methylation is a promising marker for response monitoring in patients with mCRC.
Targeting NEDDylation is a Novel Strategy to Attenuate Cisplatin-induced Nephrotoxicity
Authors: Jones Trace M. , Espitia Claudia M. , Chipollini Juan , Lee Benjamin R. , Wertheim Jason A. , Carew Jennifer S. , Nawrocki Steffan T. 
Published: January 2023

Although cisplatin remains a backbone of standard-of-care chemotherapy regimens for a variety of malignancies, its use is often associated with severe dose-limiting toxicities (DLT). Notably, 30%–40% of patients treated with cisplatin-based regimens are forced to discontinue treatment after experiencing nephrotoxicity as a DLT. New approaches that simultaneously prevent renal toxicity while improving therapeutic response have the potential to make a major clinical impact for patients with multiple forms of cancer. Here, we report that pevonedistat (MLN4924), a first-in-class NEDDylation inhibitor, alleviates nephrotoxicity and synergistically enhances the efficacy of cisplatin in head and neck squamous cell carcinoma (HNSCC) models. We demonstrate that pevonedistat protects normal kidney cells from injury while enhancing the anticancer activity of cisplatin through a thioredoxin-interacting protein (TXNIP)-mediated mechanism. Cotreatment with pevonedistat and cisplatin yielded dramatic HNSCC tumor regression and long-term animal survival in 100% of treated mice. Importantly, the combination decreased nephrotoxicity induced by cisplatin monotherapy as evidenced by the blockade of kidney injury molecule-1 (KIM-1) and TXNIP expression, a reduction in collapsed glomeruli and necrotic cast formation, and inhibition of cisplatin-mediated animal weight loss. Inhibition of NEDDylation represents a novel strategy to prevent cisplatin-induced nephrotoxicity while simultaneously enhancing its anticancer activity through a redox-mediated mechanism.

Significance:
Cisplatin therapy is associated with significant nephrotoxicity, which limits its clinical use. Here we demonstrate that NEDDylation inhibition with pevonedistat is a novel approach to selectively prevent cisplatin-induced oxidative damage to the kidneys while simultaneously enhancing its anticancer efficacy. Clinical evaluation of the combination of pevonedistat and cisplatin is warranted.
Integrated, Longitudinal Analysis of Cell-free DNA in Uveal Melanoma
Authors: Wong Derek , Luo Ping , Znassi Nadia , Arteaga Diana P. , Gray Diana , Danesh Arnavaz , Han Ming , Zhao Eric Y. , Pedersen Stephanie , Prokopec Stephenie , Sundaravadanam Yogi , Torti Dax , Marsh Kayla , Keshavarzi Sareh , Xu Wei , Krema Hatem , Joshua Anthony M. , Butler Marcus O. , Pugh Trevor J. 
Published: January 2023

Uveal melanomas are rare tumors arising from melanocytes that reside in the eye. Despite surgical or radiation treatment, approximately 50% of patients with uveal melanoma will progress to metastatic disease, most often to the liver. Cell-free DNA (cfDNA) sequencing is a promising technology due to the minimally invasive sample collection and ability to infer multiple aspects of tumor response. We analyzed 46 serial cfDNA samples from 11 patients with uveal melanoma over a 1-year period following enucleation or brachytherapy (n = ∼4/patient) using targeted panel, shallow whole genome, and cell-free methylated DNA immunoprecipitation sequencing. We found detection of relapse was highly variable using independent analyses (P = 0.06–0.46), whereas a logistic regression model integrating all cfDNA profiles significantly improved relapse detection (P = 0.02), with greatest power derived from fragmentomic profiles. This work provides support for the use of integrated analyses to improve the sensitivity of circulating tumor DNA detection using multi-modal cfDNA sequencing.Significance:Here, we demonstrate integrated, longitudinal cfDNA sequencing using multi-omic approaches is more effective than unimodal analysis. This approach supports the use of frequent blood testing using comprehensive genomic, fragmentomic, and epigenomic techniques.
Wellness in the Light of the Eschaton: Reading the Psalms with Augustine
Authors: Ticciati Susannah 
Published: January 2023

Abstract
This article considers wellness in terms of creaturely integrity, asking how the latter might be reconceived in the light of the eschaton. To that end, it draws on Augustine’s eschatological reading of the Psalms in his Enarrationes in Psalmos. It suggests that an eschatological vision reveals the “wholes” we habitually seek to be only partial wholes, which have a tendency to become “totalizing wholes.” Having offered an account of Augustine’s totus Christus hermeneutic, it turns to his interpretation of Psalm 30 (31), tracing it in terms of the paired concepts of opacity and transparency. It argues that the singing of the Psalms is, for Augustine, our present training in the transparency of the eschaton. It concludes by showing how such an eschatological orientation inculcates a posture humble courage, in which totalizing wholes are critiqued as previously overlooked creaturely connections come into view.
Feasts, Food and Fall of the Aristocratic Jia Family in Honglou meng
Authors: Jiang Xiaohu 
Published: January 2023

Abstract
Drawing upon food studies, this paper undertakes an analysis of the narrative functions of feasts and food in the novel Honglou meng (A Dream of Red Mansions, or The Story of the Stone). These alimentary elements play a vital role in the social bonds between the Jia family and other elite groups, disclosing the complex distribution of power within the Jia household and displaying internal financial issues and the external threats that have exacerbated the fall of this aristocratic family, manifesting the familial and dynastical trajectories from glory to crisis within the novel.
Possessive and Caritive in Nivkh
Authors: Gruzdeva Ekaterina 
Published: January 2023

Abstract
This paper focuses on the various encoding strategies and other relevant issues pertaining to affirmative and negative predicative possession in the two Amuric languages, Amur Nivkh and Sakhalin Nivkh (Nighvng). One of the goals is to demonstrate that possessive negation serves as a major strategy for expressing caritive semantics (= non-involvement). Constructions rendering possessive and caritive meanings represent one of the basic and rather frequent types of clauses in Nivkh, and they are also interconnected both semantically and grammatically with other clause types. Some of the constructions present in Nivkh have analogues in the neighboring languages, while others are specific to Nivkh. The present paper, based on the author’s field materials, represents the first specific study of this topic.
Ga-68-Edotreotide Positron Emission Tomography/Computed Tomography Somatostatin Receptors Tumor Volume Predicts Outcome in Patients With Primary Gastroenteropancreatic Neuroendocrine Tumors
Authors: Gallicchio Rosj , Giordano Alessia , Milella Mariarita , Storto Rebecca , Pellegrino Teresa , Nardelli Anna , Nappi Antonio , Tarricone Luigia , Storto Giovanni 
Published: January 2023

Background We retrospectively aimed to assess the prognostic significance of somatostatin receptor (SSTR) standardized uptake value (SUVmaxsstr), SSTR representative tumor volume (RTVsstr) and total lesion SSTR expression (TLsstr) obtained by [68Ga]Ga-edotreotide PET/CT ([68Ga]Ga-SSTR PET/CT) in patients with primary gastroenteropancreatic neuroendocrine tumors (GEP-NET) before surgery. Material and Methods We analyzed patients who underwent [68Ga]Ga-SSTR PET/CT 3-6 weeks before surgery from February 2020 to April 2022. The mean SUVmaxsstr value, the RTVsstr (cm3; 42% threshold) and the TLsstr (g) were registered. Thereafter the patients were followed up 10.3 months (range 3-27). The PET/CT results were compared to the event free survival (EFS). Results Forty-two patients (61 ± 13 years) have been enrolled. At multivariate analysis only RTVsstr values were predictive. The Kaplan-Meier survival analysis for RTVsstr showed a significant better EFS in patients presenting lower values as compared to those having greater ( P = .003, log-rank test). SUVmaxsstr was not suitable for predicting EFS, TLsstr mildly. Conclusion RTVsstr represents a valuable volumetric parameter able to predict the outcome in GEP-NET patients who underwent surgery. The magnitude of the SSTR representative tumor burden holds a predominant value for determining the response to therapy in GEP-NET patients before surgery, rather than the maximal SSTR representation at single voxel.
Association Between Child Maltreatment and Substance Use Disorder Across Emerging Adulthood
Authors: Guastaferro Kate , Linden-Carmichael Ashley N. , Chiang Shou-Chun 
Published: January 2023

Child maltreatment is associated with substance use beginning in adolescence and throughout early adulthood. Substance use disorders (SUD) are most likely to develop during emerging adulthood (18–25 years old). Thus, to develop effective substance use prevention strategies, it is useful to know the ages at which associations between maltreatment exposure (prior to age 18) and SUD are most strongly tied. This study examined the age-varying association between child maltreatment and past-year SUD in emerging adulthood by sex and by maltreatment type using time-varying effect models (TVEM). Data were from the National Epidemiological Survey on Alcohol and Related Conditions (NESARC-III). The analytic sample consisted of 5194 emerging adults. The association was strongest at younger ages, with individuals who experienced child maltreatment having three times greater odds of reporting SUD in the past-year. Differential associations were found by sex, racial-ethnic group, and maltreatment type across age. Prevention efforts may be more effective if their development is informed by these important differences and targeted at emerging adults rather than adolescents.
Decline in spontaneous cervical artery dissection incidence during COVID-19 public health measures: Evidence for a role of upper respiratory infections in pathogenesis
Authors: Mayer-Suess Lukas , Heidbreder Anna , Kiechl Stefan , Knoflach Michael 
Published: January 2023

Background: Upper respiratory infections have been suggested as a risk factor for spontaneous cervical artery dissection (sCeAD). If this is the case, public health measures implemented to contain the spread of SARS-CoV-2, which also reduced other communicable diseases such as influenza, might be associated with a reduction in cervical artery dissection incidence. Aims: We determined the incidence of sCeAD before, during and after the COVID-19 pandemic, and the associated public health measures. Methods: All patients suffering an sCeAD and seen in Innsbruck Austria, between January 2002 to December 2016 (pre-COVID comparators) and between January 2020 to August 2022 were recorded through two individual prospective cohort studies. We compared admission rates, demographic, and clinical characteristics of sCeAD patients in pre-COVID-19 and COVID-19 times. Results: In total, 249 sCeAD patients were admitted prior to the COVID-19 pandemic compared to 20 during its course. Baseline characteristics of sCeAD subjects did not differ in subjects admitted during and prior to the pandemic. Following the introduction of public health measures for the pandemic, there was a marked decrease of sCeAD admissions from 16.5 per year to 6.3 per year (p = 0.012). Since the measures were ended the number of sCeAD admissions increased again. In contrast, the number of all ischemic stroke patients treated at the Medical University of Innsbruck did not alter during the pandemic. (N per year: 633 in 2015, 687 in 2017, 684 in 2019, 731 in 2020, and 717 in 2021). Conclusion: The incidence of sCeAD fell markedly during the pandemic and this may have resulted from the public health measures introduced and a subsequent reduction in upper respiratory infections. Our study provides indirect evidence for a role of infection in the pathogenesis of sCeAD. Data access statement: Anonymized data not published within this article will be made available by request from any qualified investigator.
Severity of illness and mortality among children admitted to a tertiary referral hospital in Botswana: A secondary data analysis of a prospective cohort study
Authors: Richards Sheyla Denise , Hayes Molly , Mazhani Loeto , Arscott-Mills Tonya , Mulale Unami , Coffin Susan , Steenhoff Andrew P , Kitt Eimear 
Published: January 2023

Objectives: Data on triage practices of children admitted to Princess Marina Hospital in Gaborone, Botswana is limited. The inpatient triage, assessment, and treatment score was developed for low resource settings to predict mortality in children. We assess its performance among children admitted to Princess Marina Hospital and their demographic, clinical, and risk factors for death. Methods: This was a secondary data analysis of a prospective cohort study comprising 299 children ages 1 month to 13 years admitted June to September 2018. Descriptive statistics, bivariate analysis, and multivariate logistic regression were used. Sensitivity and specificity data were generated for the inpatient triage, assessment, and treatment score. Results: Thirteen children died (13/284, 4.6%). Comorbidity (adjusted odds ratio 4.0, p = 0.020) and high inpatient triage, assessment, and treatment score (adjusted odds ratio 5.0, p = 0.017) increased odds of death. The area under the receiver operating characteristic curve was 0.81. Using inpatient triage, assessment, and treatment cutoff of 4, the sensitivity, specificity, and likelihood ratio were 31%, 94%, and 5.0, respectively. Conclusion: Implementing the inpatient triage, assessment, and treatment score in low resource settings may improve identification, treatment, and evaluation of the sickest children.
Minimally Invasive Surgery Using a Shannon Burr for the Treatment of Hallux Valgus Deformity: A Systematic Review
Authors: Gonzalez Tyler , Encinas Rodrigo , Johns William , Benjamin Jackson J. 
Published: January 2023

Background: Recently there has been an increase in minimally invasive surgery (MIS) for the correction of hallux valgus deformity. This systematic review aims to evaluate and present the current literature on MIS hallux valgus correction in studies reporting the use of the Shannon burr with distal metatarsal osteotomies to help establish evidence-based guidelines for surgeons using this technique. Methods: Two independent authors performed a systematic literature search using the following databases: PubMed, Embase, and the Cochrane library. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) protocol and the Cochrane Handbook guidelines were followed. All studies included were published from 2008 to 2022 and included the use of the Shannon burr during distal metatarsal osteotomies MIS for hallux valgus and at least 12-month follow-up. The MINORS score criteria was used to evaluate the strength and quality of 17 studies by 3 authors. Statistical analysis and meta-analysis were not performed because of the heterogeneity of the included studies and the data being descriptive. Results: A total of 17 studies were reviewed. A total of 911 subjects were included, and 1088 MIS procedures were performed. The average follow-up was 23.8 (12-59.1) months. American Orthopaedic Foot & Ankle Society scale and visual analog scale scores improved from 52.1 (41-62.5) to 90.3 (83.3-97.1) and 4.9 (3-8.2) to 0.8 (0-1.9). Satisfaction rates were very high among the studies that reported it. The hallux valgus angle, intermetatarsal angle, and distal metatarsal articular angle improved from 31.4 (23.5-44.1) to 11.1 (7-17.2), 13.4 (8.1-18.6) to 7.3 (4.2-10.3), and 12.3 (9-16.3) to 4.1 (1-6.7), respectively. The complication rate was 16.6%, and recurrence was 2.2%. Nonunion comprised 0.4%, infections 1.1%, nerve injury 2.2%, avascular necrosis 0%, hallux varus 0.09%, transfer metatarsalgia 0.1%, and hardware removal 6.2%. Conclusion: MIS for the treatment of hallux valgus using the Shannon burr appears to be a safe and effective therapy, with appropriate correction of the hallux valgus deformity, improvement in functional outcomes, high patient satisfaction, low recurrence, and acceptable complication rates. Level of Evidence: Level II, systematic review.
Understanding the Public Health Role, Motivations, and Perceptions of Community Health Workers Deployed to Low-Income Housing in Richmond, Virginia
Authors: Obasanjo Iyabo , Scott Alison , Griffin Monica , Agyemang-Duah Amma , Westhoff Charlie , Toney Stephanie , Shelton Patrice 
Published: January 2023

Background For the US health indicators to improve to the level of other developed countries, the use of Community Health Workers (CHWs) in vulnerable populations has been indicated as a possible long-term intervention. There are few models of long-term deployment of CHWs as part of the district level public health system in the US. Method In this study we interviewed CHWs who served as neighborhood-integrated health district staff assigned to low-income housing in Richmond, Virginia for 10 years. Qualitative analyses of their taped and transcribed interviews resulted in 5 themes from the interviews. The themes were Activities, Satisfaction, Strengths, Facilitation/Resources and Challenges. We highlighted quotes from the CHWs interviews for themes and summarized the findings from each theme. Results CHWs carried out a variety of activities daily and these were described. The CHWs were generally satisfied with their job because it enabled them to assist others. The strength of their communities was resilience, and the resources they needed more included physical resources, human resources, political support, and more comprehensive programming. Their client’s challenges include transportation, mental health, and physical safety and the CHWs challenge to effectively carrying out their work with clients was trust by community members. Conclusion The information garnered from the CHWs would be useful in designing CHW programs at other health districts.