bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inequities in home care use among older Canadian adults: Are they corrected by public funding?
Authors: Vafaei Afshin , Rodrigues Ricardo , Ilinca Stefania , Fors Stefan , Kadi Selma , Zolyomi Eszter , Phillips Susan P. 
Published: February 2023

Background
Although care use should parallel needs, enabling and predisposing circumstances including the socio-demographic inequities of socioeconomic status (SES), gender, or isolation often intervene to diminish care. We examine whether availability of state-funded medical and support services at home can rebalance these individual and social inequities, and do this by identifying if and how intersecting social identities predict homecare use among older Canadian adults.

Methods
Using the Canadian Longitudinal Study on Aging (CLSA) of 30,097 community-dwelling adults aged 45 to 85, we performed recursive partitioning regression tree analysis using Chi-Squared automatic interaction detection (CHAID). Combinations of individual and social characteristics including sociodemographic, family-related, physical and psychological measures and contextual indicators of material and social deprivation were explored as possible predictors of formal and informal care use.

Results
Diminished function i.e. increased need, indicated by Activities of Daily Living, was most strongly aligned with formal care use while age, living arrangement, having no partner, depression, self-rated health and chronic medical conditions playing a lesser role in the pathway to use. Notably, sex/gender, were not determinants. Characteristics aligned with informal care were first—need, then country of birth and years since immigration. Both ‘trees’ showed high validity with low risk of misclassification (4.6% and 10.8% for formal and informal care, respectively).

Conclusions
Although often considered marginalised, women, immigrants, or those of lower SES utilised formal care equitably. Formal care was also differentially available to those without the financial or human resources to receive informal care. Need, primarily medical but also arising from living arrangement, rather than SES or gender predicted formal care, indicating that universal government-funded services may rebalance social and individual inequities in formal care use.
Failure and multiple failure for disease modifying antirheumatic drugs in rheumatoid arthritis: Real-life evidence from a tertiary referral center in Italy
Authors: Conigliaro Paola , D’Antonio Arianna , D’Erme Luca , Lavinia Fonti Giulia , Triggianese Paola , Bergamini Alberto , Chimenti Maria Sole 
Published: February 2023

Background
Rheumatoid Arthritis (RA) is a chronic inflammatory disease with a heterogeneous treatments’ clinical response. Goals of treatment are remission and low disease activity, which are not achieved in all patients despite the introduction of early treatment and the treat to target strategy.

Objective
To investigate the causes of disease-modifying antirheumatic drugs (DMARDs) discontinuation and treatment failure and multiple failure for inefficacy, and to identify possible failure predictors’ according to RA patient characteristics in a real-world setting.

Methods
718 RA patients were retrospectively evaluated. Conventional synthetic (cs) and biologic (b)DMARDs treatments line/s, effectiveness, and reasons of discontinuations were evaluated. Patients failing to at least two csDMARDs or bDMARDs’ drug for inefficacy were defined “csDMARDs multifailure” and “bDMARDs multifailure”, respectively. Discontinuation of at least two cs- and bDMARDs was termed “global multifailure”.

Results
In total, 1422 csDMARDs and 714 bDMARDs treatment were analysed. Causes of csDMARDs discontinuation were intolerance (21.8%), inefficacy (20.2%), acute adverse reactions (5.3%) and severe infections (0.6%) while csDMARDs multifailure for inefficacy was observed in 5.7% of cases. Reasons of bDMARDs withdrawal were inefficacy (29%), intolerance (10.0%), acute adverse reaction (6.3%) and severe infections (1.5%). Altogether, 8.4% of patients were bDMARDs multifailure for inefficacy while 16.6% were global multifailure. Longstanding disease (≥ 12 months) and smoke habit, resulted as positive predictor of csDMARDs failure (OR 2.6 and OR 2.7, respectively). Thyreopathy was associated with both csDMARDs failure and global multifailure (OR 2.4 and OR 1.8, respectively). Higher prevalence of failure to at least one bDMARDs and global multifailure was detected in female than male (OR 2.3 and OR 2, respectively).

Conclusions
Different causes of drug discontinuation were observed on DMARDs treatments. Demographic and clinical features were identified as possible predictors of both cs- and bDMARDs treatment failure and multiple failure, underlining the need of a more personalized therapeutic approach to achieve treatment targets.
Exploring facial expressions and action unit domains for Parkinson detection
Authors: Gomez Luis F. , Morales Aythami , Fierrez Julian , Orozco-Arroyave Juan Rafael 
Published: February 2023

Background and objective
Patients suffering from Parkinson’s disease (PD) present a reduction in facial movements called hypomimia. In this work, we propose to use machine learning facial expression analysis from face images based on action unit domains to improve PD detection. We propose different domain adaptation techniques to exploit the latest advances in automatic face analysis and face action unit detection.

Methods
Three different approaches are explored to model facial expressions of PD patients: (i) face analysis using single frame images and also using sequences of images, (ii) transfer learning from face analysis to action units recognition, and (iii) triplet-loss functions to improve the automatic classification between patients and healthy subjects.

Results
Real face images from PD patients show that it is possible to properly model elicited facial expressions using image sequences (neutral, onset-transition, apex, offset-transition, and neutral) with accuracy improvements of up to 5.5% (from 72.9% to 78.4%) with respect to single-image PD detection. We also show that our proposed action unit domain adaptation provides improvements of up to 8.9% (from 78.4% to 87.3%) with respect to face analysis. Finally, we also show that triplet-loss functions provide improvements of up to 3.6% (from 78.8% to 82.4%) with respect to action unit domain adaptation applied upon models created from scratch. The code of the experiments is available at https://github.com/luisf-gomez/Explorer-FE-AU-in-PD.

Conclusions
Domain adaptation via transfer learning methods seem to be a promising strategy to model hypomimia in PD patients. Considering the good results and also the fact that only up to five images per participant are considered in each sequence, we believe that this work is a step forward in the development of inexpensive computational systems suitable to model and quantify problems of PD patients in their facial expressions.
Imaging delays among medical inpatients in Toronto, Ontario: A cohort study
Authors: Bartsch Emily , Shin Saeha , Roberts Surain , MacMillan Thomas E. , Fralick Michael , Liu Jessica J. , Tang Terence , Kwan Janice L. , Weinerman Adina , Verma Amol A. , Razak Fahad , Lapointe-Shaw Lauren 
Published: February 2023

Background
Imaging procedures are commonly performed on hospitalized patients and waiting for these could increase length-of-stay. The study objective was to quantify delays for imaging procedures in General Internal Medicine and identify contributing patient, physician, and system factors.

Methods
This was a retrospective cohort study of medical inpatients admitted to 5 hospitals in Toronto, Ontario (2010–2019), with at least one imaging procedure (CT, MRI, ultrasound, or peripherally-inserted central catheter [PICC] insertion). The primary outcome was time-to-test, and the secondary outcome was acute length-of-stay after test ordering.

Results
The study cohort included 73,107 hospitalizations. Time-to-test was longest for MRI (median 22 hours) and shortest for CT (median 7 hours). The greatest contributors to time-to-test were system factors such as hospital site (up to 22 additional hours), location of test ordering (up to 10 additional hours), the timing of test ordering relative to admission (up to 13 additional hours), and ordering during weekends (up to 21 additional hours). Older patient age, having more comorbidities, and residence in a low-income neighborhood were also associated with testing delays. Each additional hour spent waiting for a test was associated with increased acute length-of-stay after test ordering, ranging from 0.4 additional hours for CT to 1.2 hours for MRI.

Conclusions
The greatest contributors to testing delays relate to when and where a test was ordered. Wait times affect length-of-stay and the quality of patient care. Hospitals can apply our novel approach to explore opportunities to decrease testing delays locally.
Measuring Sustainable Ecocentric Views of Young Entrepreneurs with NEP Scale - A Way Forward to Oman 2040 vision
Authors: Suresh Samyuktha P. , Simon Simi 
Published: February 2023

Oman’s vision 2040 focuses on four main pillars of People, Economy, Institutions and Environment. Every nation’s economy greatly benefits from its environment, both directly and indirectly. Direct usage is through its use in manufacturing and indirect usage is through the myriad of services it offers. In recent decades, the nature of the environmental concerns facing the world has undergone a major shift. The best defense to sustain the environment is to instill awareness among the youth. This research attempted to initiate this defense mechanism through an assessment of environmental paradigms among budding Omani entrepreneurs. Researchers adopted an area sampling design to select respondents from designated food service-sectors. Data collection was administered through a structured questionnaire using NEP scale focused on five facets such as Reality of Limits to Growth, Anti-anthropocentrism, Fragility of Nature’s Balance, Rejection of Exemptionalism and Possibility of an Eco-Crisis. The analysis included Descriptive statistics, student’s t test, ANOVA and multiple comparison using Tukey HSD test that revealed the impact of respondents’ gender, type of business and location on environmental paradigms to comprehend creative entrepreneurs' willingness to sustain natural resources in support of Oman's Vision 2040.
Keywords: Ecocentric views; Young Entrepreneurs; NEP scale; Sustainable Development (SD); Oman Vision 2040
Tendencies and Perspectives of Organic Farming Development in the EU – the Significance of European Green Deal Strategy
Authors: Wrzaszcz Wioletta 
Published: February 2023

Organic system of agricultural production is particularly important in the context of agriculture sustainability. Taking into consideration sustainability premises, agricultural sector should deliver environmental, social and economic profits. One of the most important form of agriculture in this context is organic production. In 2019, the European strategy of Green Deal underlined the need of further and faster development of organic farms in the EU. The purpose of the paper is establishing current tendencies, as well as perspectives of organic farming development, including its market environment in the EU. The accent was focused on Poland`s situation and experiences. The period of the analysis covered the years 2012-2020. The data used in the research came from national institution Agricultural and Food Quality Inspection, Statistics Poland reports and papers, as well as database of Eurostat. Indicator analysis methods were used and trends were established.
The results of the study revealed, that during the analyzed period, organic farming developed in the EU. The main statistics, such as the number of organic farms and organic agricultural land improved significantly. The current trends in individual European countries in the field of development of the organic management system indicate, that this segment of the agricultural market has different significance in individual countries, which may also result from local economic and market conditions. Based on the research results, it was stated, that organic farming development in the EU – in the nearest further – will be challenging, especially in the context of the european strategic purposes, presented in Green Deal documents.
Keywords: organic farming, organic farms, agricultural land in organic system of production, organic processors, European Green Deal strategy, EU, Poland
Investigating the Impact of Structural Changes: The Socio-Economic Security Framework
Authors: Pakhucha Elina , Sievidova Iryna , Romaniuk Iryna , Bilousko Tamila , Tkachenko Serhii , Diadin Andrii , Babko Natalia 
Published: February 2023

This study shows that ensuring socio-economic security of the country, which is defined as a set of conditions necessary to ensure normal economic development. It is almost the most important determinant that determines the favorable conditions of economic activity of economic entities. In general, the socio-economic security of business entities ensures the ability to create and maintain such conditions of economic activity, under which the influence of external and internal factors does not lead to negative processes regarding sustainable development, necessary for achieving the set goals. It considers the system approach to the assessment of socio-economic security of business entities considers which includes the following assessment parameters: main purpose and objectives of the analysis of socio-economic security, selecting types of the analysis of socio-economic security, establishing basic rules and analysis stages, selecting and using basic models, methods and indicators to assess socio-economic security, construction of the aggregated indicator. The study researches of the methods of assessment of socio-economic security. It suggests that the index of socio-economic security is defined by comparing volumes of a company's gross investments and the amount of resources needed to maintain an optimal indicator of socio-economic security, since the source of socio-economic security is the profit received by the company resulting from the interaction with external environment subjects. According to the results of the conducted assessment of socio-economic security by comparing volumes of the company's gross investments and the amount of resources needed to maintain an optimal indicator of socio-economic security, the integral estimate of security in recent years was obtained. The article outlines the aspects of simulating the socio-economic security of business entities, conducted by means of correlation and regression analysis and by forecasting the future security level using quantitative indicators. Using the trends, the paper analyzes the principle and characteristics of other simulating and forecasting techniques and identifies their advantages and disadvantages. It allows considering as practicable the use of correlation and regression analysis and its results, while making management decisions to enhance the socio-economic security of business entities.
Keywords: economic security, national economy, national security, socio-economic security, structural changes, business entities, economic structure, modelling
Overeducation in Arab Labour Markets; Different Measures, Different Outcomes
Authors: Alattas Halah 
Published: February 2023

Since the introduction of the topic of overeducation, there has been a methodological debate on the most effective measurement tool. This debate has concluded that there is no single most appropriate method to measure overeducation, which depends entirely on data availability. By using the Integrated Labour Market Panel Survey (ILMPS) for Egypt (1998-2018), Jordan (2010-2016) and Tunisia (2014), this paper contributes to the existing literature on overeducation by measuring it across a sample of Arab countries using different methods as specified in the literature. The results reveal that the incidence of overeducation significantly varies across the measures. The subjective WA approach yielded the highest incidence of overeducation among the measures, whereas JA approach produced the lowest incidence. The RM approach, however, fell in a middle between the two other approaches and captured the region's political conflict and social unrest. Moreover, the Spearman rank correlation between the measurements was relatively low, indicating short overlaps among workers categorized as overeducated across measures.
Keywords: Overeducation, Arab countries, Workers’ self-Assessment, Job analyst, Realized Matches.
Racial and Ethnic Disparities in Years of Potential Life Loss Among Patients With Cirrhosis During the COVID-19 Pandemic in the United States
Authors: Zhao Yunyu , Yeo Yee Hui , Samaan Jamil , Lv Fan , He Xinyuan , Liu Jinli , Li Mei , Gao Ning , Park Justin , Yang Ju Dong , Ayoub Walid S. , Zhang Lei , Odden Michelle C. , Ji Fanpu , Nguyen Mindie H. 
Published: February 2023

INTRODUCTION:
Our aim was to evaluate the impact of race/ethnicity on cirrhosis-related premature death during the COVID-19 pandemic.

METHODS:
We obtained cirrhosis-related death data (n = 872,965, January 1, 2012–December 31, 2021) from the US National Vital Statistic System to calculate age-standardized mortality rates and years of potential life lost (YPLL) for premature death aged 25–64 years.

RESULTS:
Significant racial/ethnic disparity in cirrhosis-related age-standardized mortality rates was noted prepandemic but widened during the pandemic, with the highest excess YPLL for the non-Hispanic American Indian/American Native (2020: 41.0%; 2021: 68.8%) followed by other minority groups (28.7%–45.1%), and the non-Hispanic White the lowest (2020: 20.7%; 2021: 31.6%). COVID-19 constituted >30% of the excess YPLLs for Hispanic and non-Hispanic American Indian/American Native in 2020, compared with 11.1% for non-Hispanic White.

DISCUSSION:
Ethnic minorities with cirrhosis experienced a disproportionate excess death and YPLLs in 2020–2021.
Subcutaneous Sweet Syndrome Successfully Treated With Ustekinumab in a Patient With Ulcerative Colitis
Authors: Hu Kelly A. , Shen Jeanne , Rieger Kerri , Wei Mike T. , Gubatan John 
Published: February 2023

ABSTRACT
Ustekinumab, an inhibitor of the interleukin-12/23 pathway, received Food and Drug Administration (FDA) approval in 2019 for induction and maintenance therapy in patients with moderate-to-severe ulcerative colitis (UC). Data regarding the efficacy of ustekinumab in the treatment of extraintestinal manifestations of UC are unclear. Sweet syndrome, an acute febrile neutrophilic dermatosis, is a cutaneous manifestation of inflammatory bowel disease that parallels disease activity. In this study, we present the first case of subcutaneous Sweet syndrome with sterile osteomyelitis in a patient with UC successfully treated with ustekinumab.
Sporadic Neurofibroma of the Peritoneal Cavity
Authors: Shah Rahil H. , Forde Justin , Arora Kshitij Satnamdas , Bhalla Sean , Amin Sunil , Kumar Shria 
Published: February 2023

ABSTRACT
Neurofibromas are peripheral nerve sheath tumors that are typically seen in syndromic conditions such as neurofibromatosis 1. We present the case of a 26-year-old woman suffering from chronic abdominal pain for over 5 years. Prior workup showed a large retroperitoneal mass extending into the abdomen and encasing multiple major vessels. She underwent endoscopic ultrasound (EUS)-guided biopsy, which was histologically consistent with a solitary neurofibroma. There is no prior report of solitary neurofibroma of the abdomen diagnosed with the use of EUS-guided biopsy. This case highlights the utility of EUS-guided biopsy in the evaluation of intra-abdominal pathology.
Brentuximab-Induced Colitis in a Non-Stem-Cell Transplant Patient
Authors: Ali Sareena , AbdulMujeeb Sufyan , Khattab Ahmed , Asado Nahren , Fine Marc 
Published: February 2023

ABSTRACT
Many chemotherapeutic agents have been associated with drug-induced colitis (DIC). With newer agents' expansion of approval as first-line therapy for common cancers, it is important to be cognizant of their association with DIC. We present a case of brentuximab-associated DIC in an elderly woman with CD30+ Hodgkin lymphoma. Brentuximab's association with DIC was suspected by others in the literature, but a history of stem-cell transplant in them would blur the association with graft-vs-host disease. Lack of stem-cell transplant in our patient makes the link between brentuximab and DIC unambiguous.
Liberté académique j’écris ton « non » Retour sur deux publications récentes sur l’autonomie de la recherche en sciences sociales
Authors: Laurens Sylvain 
Published: February 2023

Recensés : Philippe Aldrin, Pierre Fournier, Vincent Geisser et Yves Mirman, L’enquête en danger : vers un nouveau régime de surveillance dans les sciences sociales, Paris, ArmandColin, janvier 2022, 304 p.
&
Claude Gautier, Michelle Zancarini-Fournel, De la défense des savoirs critiques. Quand le pouvoir s’en prend à l’autonomie de la recherche, Paris, La Découverte, janvier 2022, 270 p.
Perlindungan Ekspresi Budaya Tradisional Dan Indikasi Geografis: Suatu Kekayaan Intelektual Dengan Kepemilikan Komunal
Authors: Kusuma Purnama Hadi , Roisah Kholis 
Published: February 2023

Ekspresi budaya tradisional dan indikasi geografis merupakan bagian dari rezim kekayaan intelektual yang bisa dimiliki secara komunal. Kepemilikan komunal menjadi rezim kekayaan intelektual yang khas yang menjadi asset suatu golongan masyarakat tertentu yang menunjukkan corak keunikannya dan negara wajib memberikan perlindungan agar tidak diambil oleh masyarakat dari wilayah lain. Penelitian ini bertujuan untuk menganalisa bagaimana sistem perlindungan terhadap ekspresi budaya tradisional dan indikasi geografis dalam sistem hukum kekayaan intelektual yang merupakan milik bagi segelintir orang asli yang menjadi suatu keunikan yang memiliki nilai ekonomi yang membedakan daerah tersebut dengan daerah lainnya. Metode penelitian yang digunakan dalam penelitian ini merupakan jenis dari penelitian hukum normatif dengan sifat deskriptif analitis yang meneliti sumber data sekunder yang diperoleh dari membaca bahan kepustakaan yang kemudian dianalisis secara kualitatif. Upaya perlindungan ekspresi budaya tradisional dan indikasi geografis melalui ketentuan hak cipta, Neighbouring Right dan hukum kekayaan industri, dan indikasi geografis mendapatkan perlindungan melalui ketentuan TRIPs Agreement, perjanjian lisabon, dan Undang-Undang No. 20 Tahun 2016 tentang Merk dan Indikasi Geografis. Kepemilikan komunal ekspresi budaya tradisonal dan indikasi geografis berdasarkan fiolosofinya bahwa komunitas masyarakat yang berkerja keras untuk memelihara, mempertahankan dan mengembangkan Ekspresi Budaya Tradsional dan mempertahankan eksistensi karakteristik produk IG merupakan analogi labour dalam pemikiran Jhon Locke yang dijadikan legimitasi kepemilikan secara komunal oleh komunitas yang harus dihormati dan dilindungi oleh siapun juga termasuk Negara.