bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thoracoscopic surgery for atrial fibrillation in a patient with persistent left superior vena cava: a case report
Authors: Seimei Go , Shinya Takahashi , Toshiya Ohtsuka , Taiichi Takasaki 
Published: August 2023

Abstract
Background
A persistent left superior vena cava (PLSVC) is an anomaly of the thoracic venous system that flows into the right atrium via an enlarged coronary sinus. When performing pulmonary vein isolation and left atrial appendage closure, the PLSVC can interfere with the procedure. We have performed thoracoscopic surgery on such a patient and would like to share our experience.

Case presentation
The patient is a 70-year-old male with a 1-year history of repeated tachycardia with chest discomfort due to paroxysmal atrial fibrillation. Contrast-enhanced computed tomography revealed the presence of a PLSVC that flows into the right atrium. The hepatic vein flows directly into the right atrium, whereas the inferior vena cava enters the thoracic cavity next to the descending aorta and flows into the parazygous vein and PLSVC. We performed thoracoscopic stapler closure of the left atrial appendage and epicardial clamp-isolation of the pulmonary veins and the PLSVC. There was concern that the PLSVC would interfere with the visual field needed to perform the procedure. We carefully removed the adhesions to the surrounding tissue and provided mobility to the PLSVC and expanded it ventrally. As a result, the procedure could be performed safely and without complications.

Conclusions
Our results demonstrate that in cases where catheter ablation is difficult for anatomical reasons, thoracoscopic stapler closure of the LAA and epicardial clamp-isolation of pulmonary veins may be a viable option.
Esophageal replacement with pedunculated gastric conduit interposition and duodenal transection for refractory anastomotic leakage after esophagectomy
Authors: Hirata Kaiho , Yagi Shusuke , Yamada Kazuhiko , Enomoto Naoki , Nohara Kyoko , Kokudo Norihiro 
Published: August 2023

Abstract
Background
Leakage of cervical esophagogastric anastomosis is a serious complication of esophagectomy. However, there is no established way to treat the anastomosis leakage.

Case presentation
The case is a 69-year-old man with locally advanced esophageal and two early gastric cancers. After induction chemotherapy, we performed minimally invasive esophagectomy, but on postoperative day 11, the anastomotic leakage was observed. Nutritional therapy, negative-pressure wound therapy, and suture closure could not treat it. Therefore, we performed pedunculated gastric conduit interposition with duodenal transection. In this procedure, the main trunk of the right gastroepiploic artery and vein was preserved, and the duodenum and gastric antrum are resected with cutting the branch from the right gastroepiploic artery and vein to gastric antrum, which dramatically improved the flexibility of the gastric conduit, and it is pulled up through the subcutaneous route. Improved blood supply and flexibility of the gastric conduit enabled a tension-free and safe anastomosis.

Conclusions
The flexibility and favorable blood flow of pedunculated gastric conduit interposition with duodenal transection can be an effective treatment option for refractory anastomotic leakage after esophagectomy.
Successful resuscitation from acute coronary syndrome during mediastinoscope-assisted transhiatal esophagectomy: a case report
Authors: Maruyama Kiyotomi , Shimada Kou , Makino Arano , Hisamune Ryo , Kawaguchi Masanori , Ikeno Shigeo , Morita Natsuhiro , Ichioka Ken , Shimizu Tadaaki , Shirota Tomoki , Gomi Kuniyuki , Mihara Motohiro , Kajikawa Shoji 
Published: August 2023

Abstract
Background
Although unexpected cardiac arrest is a very rare intraoperative complication, strategies regarding preoperative screening and procedures to be taken in the event of an emergency need to be well established.

Case presentation
A man in his late 70 s diagnosed with thoracic esophageal cancer, cT3N1M0, and cStage III was admitted. His metabolic equivalents were 4 or more. Electrocardiogram (ECG), ultrasound cardiography, and hematological examinations revealed no severe abnormalities. Computed tomography (CT) showed highly calcified coronary arteries. We performed mediastinoscope-assisted transhiatal esophagectomy. Procedures in the mediastinum involving access from the neck and abdomen were completed uneventfully. Middle mediastinal lymph node dissection and gastrointestinal reconstruction with the patient in the prone position were scheduled for later. However, before the change in position, pulseless nonsustained ventricular tachycardia (VT) suddenly occurred and caused blood pressure to drop sharply to below 30 mmHg. The VT disappeared in approximately 20 s, and there was a return to sinus rhythm after cardiac resuscitation; however, the ECG showed a decrease in the ST segments of leads II, III, and aVF. Immediately thereafter, the patient was transferred to the cardiac catheterization laboratory for percutaneous coronary intervention. Cardiac catheterization revealed diffuse stenosis of 90% in the left anterior descending branch of the coronary artery (segment no. 6). Plain old balloon angioplasty and stent placement were performed. Dual antiplatelet therapy was needed. On the next day, thoracoscopic esophagectomy was performed in the left lateral decubitus position, followed by cervical esophagostomy in the supine position. He developed acute respiratory distress syndrome and thoracic aortic dissection on the 5th postoperative day (POD) and intraperitoneal bleeding on the 16th POD. On the 105th POD, laparoscopic-assisted cervical esophagogastric anastomosis was performed. Parkinson’s disease was diagnosed on the 126th POD. On the 313th POD, the patient was discharged.

Conclusion
Surgeons should be familiar with the guidelines for patient screening and management of intraoperative cardiac arrest. In patients with severe coronary artery calcification, further investigation such as coronary angiography CT may be necessary before esophagectomy. Furthermore, highly invasive surgery should be performed in well-equipped hospitals.
Identification of micro-recurrent lesions using methylene blue for mediastinal ectopic parathyroid adenoma: a case report
Authors: Nomura Shunsuke , Ujiie Hideki , Fujiwara-Kuroda Aki , Kaga Kichizo , Aragaki Masato , Muto Jun , Chiba Ryohei , Yamazaki Gaku , Wakabayashi Kento , Matsuno Yoshihiro , Kato Tatsuya 
Published: August 2023

Abstract
Background
Mediastinal ectopic parathyroid adenomas are rare, and several methods are used to diagnose and localize them preoperatively. Technetium-99m methoxy isobutyl isonitrile scintigraphy has been used to diagnose parathyroid tumors. However, it is difficult to identify tumors buried in adipose tissue during surgery.

Case presentation
We report a case in which methylene blue effectively identified small recurrent lesions in a mediastinal ectopic parathyroid adenoma. After intravenous injection of methylene blue prior to surgery, the stained parathyroid adenoma was easily identifiable. Additionally, we identified other small recurrent lesions that could not be confirmed on preoperative imaging using real-time in vivo imaging guidance during surgery. Using this strategy, complete macroscopic resection can be performed during video-assisted thoracic surgery.

Conclusion
Preoperative intravenous methylene blue injection is useful for identifying small recurrent lesions, even in cases of mediastinal ectopic parathyroid adenoma with suspected recurrence.
Strengthening community midwives to tackle gender-based vulnerabilities during the 2022 floods in Pakistan—lessons learned for future natural disasters
Authors: Kamran Iram , Mir Ali Mohammad 
Published: July 2023

AbstractSeveral countries across different continents experienced severe flooding in 2022, including Pakistan. Given the greater frequency and affliction of natural disasters like flooding in an increasing number of countries, we share lessons from the experience of Pakistan in helping the most vulnerable populations through community-based health workers.
Communication strategies to promote vaccination behaviours in sub-Saharan Africa
Authors: West Rebecca L. , Hurst Nisa , Sharma Sunny , Henry Beverley , Vitale-Rogers Shannon , Mutahi William , Salt Frances , Gardner Cassie , Turley Gareth , Ezeanochie Nnamdi , Betik Jason , Panagiotakopoulou Sofia , April Janice , Paige Samantha R. 
Published: July 2023

AbstractEffective public health communication is needed to increase COVID-19 vaccination uptake in sub-Saharan Africa. We present six best practices: (1) use of collective action/altruism, (2) use of relatable language, (3) tailoring messages, (4) use of gain-framed messages, (5) use of trusted messengers and (6) use of research to test messages.
The barriers to cervical cancer screening for urban and rural populations in Rwanda
Authors: Dau Hallie , Vidler Marianne , AboMoslim Maryam , Mutamba Barbra , Nesbitt Zoey , Deodatha John , Byiringiro Schadrack Danson , Niyotwiringiye Charles , Mithani Nadia , Nair Varun , Smith Laurie , Rulisa Stephen , Ogilvie Gina 
Published: July 2023

Abstract
Background
Cervical cancer is the leading cause of cancer mortality in Rwandan women. There is a limited understanding of the barriers that women face to obtain cervical cancer screening in Rwanda. It is important to understand the barriers in order to implement effective screening programs. The goal of this study is to describe the barriers to cervical cancer screening among women in Rwanda and how they differ among women in rural and urban areas.

Methods
This cross-sectional study recruited women from June 1 to 9, 2022, at Muhima and Nyamata District Hospitals in Rwanda. Women were eligible for the study if they were ≥ 18 years and spoke Kinyarwanda or English. Women completed a 15-min survey which included questions on the participants’ demographics, knowledge of cervical cancer, cervical cancer screening history, and barriers to healthcare. Women were stratified by survey location (urban vs rural). Descriptive statistics were reported.

Results
A total of 374 women completed the survey with 169 participants from Muhima and 205 from Nyamata. Most women were in a relationship and had a primary school or less education. The most common barriers to accessing general healthcare services were long wait times at the facility (Muhima 26%; Nyamata 30%), low quality of care (Muhima 15%; Nyamata 12%), and transportation costs (Muhima 13%; Nyamata 9.3%). However, women from Nyamata were significantly more likely to report distance to the health center as a barrier (p-value < 0.001), and women from Muhima were significantly more likely to report transportation method as a barrier (p-value = 0.004). The primary reason reported for not obtaining cervical cancer screening was that women did not know how or where to get tested (Muhima 57%; Nyamata 51%).

Conclusions
The most common barriers to cervical cancer screening in Rwanda were the quality of clinical care and issues with traveling to the clinic. Implementing a cervical cancer self-collection program could help eliminate many barriers that women face to obtain health services in Rwanda. More research is needed to better understand the acceptability of cervical cancer screening in Rwanda and how it could be integrated into the healthcare system.
Glucocorticoid receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain
Authors: Eachus Helen , Oberski Lara , Paveley Jack , Bacila Irina , Ashton John-Paul , Esposito Umberto , Seifuddin Fayaz , Pirooznia Mehdi , Elhaik Eran , Placzek Marysia , Krone Nils P. , Cunliffe Vincent T. 
Published: August 2023

ABSTRACT
Glucocorticoid resistance is commonly observed in depression, and has been linked to reduced expression and/or function of the glucocorticoid receptor (NR3C1 in human, hereafter referred to as GR). Previous studies have shown that GR-mutant zebrafish exhibit behavioural abnormalities that are indicative of an affective disorder, suggesting that GR plays a role in brain function. We compared the brain methylomes and brain transcriptomes of adult wild-type and GR-mutant zebrafish, and identified 249 differentially methylated regions (DMRs) that are regulated by GR. These include a cluster of CpG sites within the first intron of fkbp5, the gene encoding the glucocorticoid-inducible heat shock protein co-chaperone Fkbp5. RNA-sequencing analysis revealed that genes associated with chaperone-mediated protein folding, the regulation of circadian rhythm and the regulation of metabolism are particularly sensitive to loss of GR function. In addition, we identified subsets of genes exhibiting GR-regulated transcription that are known to regulate behaviour, and are linked to unipolar depression and anxiety. Taken together, our results identify key biological processes and novel molecular mechanisms through which the GR is likely to mediate responses to stress in the adult zebrafish brain, and they provide further support for the zebrafish GR mutant as a model for the study of affective disorders.
Immunocytochemical detection of non-histone nuclear antigens in cryosections of developing somatic embryos from Daucus carota L
Authors: Sanchez-Pina M. A. , Kieft H. , Schel J. H. N. 
Published: July 2023

ABSTRACT
The distribution of non-histone nuclear antigens was studied during early somatic embryogenesis of carrot using nuclear antibodies specific for small nuclear RNPs (snRNPs), nuclear matrix proteins and nucleolar proteins. Immunofluorescence showed that in interphase cells snRNPs and nuclear matrix proteins were localized in the nucleus with a speckled pattern. Immunoelectron microscopy indicated that the snRNPs were irregularly distributed while the nuclear matrix proteins showed a distribution preferentially over the condensed chromatin. None were localized in the nucleolus. The nucleolar proteins were localized in both dense fibrillar and granular components while the fibrillar centres were devoid of gold particles.
The localization of these antibodies in plant cell nuclei, in a way comparable to the patterns described in animal cells, indicates the general presence of snRNPs in all eukaryotic nuclei. It further confirms the relation of the nuclear matrix proteins to plant cell proliferation events and the possible role of the nucleolar proteins in both rRNA transcription and preribosome assembly.
Prescriber’s view on anticholinergic deprescribing among older adults with intellectual disability: A qualitative study protocol
Authors: Al Shuhaimi Lamya , Henman Martin C , McCallion Philip , McCarron Mary , O'Dwyer Maire 
Published: August 2023

Background: High anticholinergic burden is associated with physical and cognitive functional decline however, these medications are still being prescribed for older adults with intellectual disability. People with intellectual disability exposed to higher anticholinergic burden compared to general population. Additionally, anticholinergic exposure is higher with aging, neurological and psychiatric health conditions, living in nursing homes or community group setting. The long-term exposure to high anticholinergic burden was associated with physical decline, cognitive impairment, higher risk of dementia and Alzheimer disease. Aim and objectives: The study aimed to explore prescriber views and perspective about prescribing and deprescribing of medication with anticholinergic activity among older adults with intellectual disability. the objectives of this study are: To explore prescriber’s knowledge on anticholinergic burden, adverse-effects, tools used to measure anticholinergic burden.To explore barriers and facilitators of anticholinergic deprescribing. Method and analysis: this is a qualitative semi-structured interviews study which will be conducted by interviewing prescribers involved in prescribing for older adults with intellectual disabilities. The study aimed to recruit 8 – 10 prescribers or until it reaches data saturation. Interviews will be conducted through MS teams or in person if that’s suits the interviewee. This study will be conducted by based on the Theoretical Domain Framework (TDF).
Gaussian Process-Based Random Search for Continuous Optimization via Simulation
Authors: Wang Xiuxian , Hong L. Jeff , Jiang Zhibin , Shen Haihui 
Published: August 2023

A gaussian process-based random search framework for continuous optimization via simulation Stochastic optimization via simulation (OvS) is widely used for optimizing the performances of complex systems with continuous decision variables. Because of the existence of simulation noise and infinite feasible solutions, it is challenging to design an efficient mechanism to do the searching and estimation simultaneously to find the optimal solutions. In “Gaussian process-based random search for continuous optimization via simulation,” Wang et al. propose a Gaussian process-based random search (GPRS) framework for the design of single-observation and adaptive continuous OvS algorithms. This framework builds a Gaussian process surrogate model to estimate the objective function value of every solution based on a single observation of each sampled solution in each iteration and allow for a wide range of sampling distributions. They prove the global convergence and analyze the rate of convergence for algorithms under the GPRS framework. They also give a specific example of GPRS algorithms and validate its theoretical properties and practical efficiency using numerical experiments.
The effect of colony translocation on meliponaries of Melipona scutellaris (L.) (Hymenoptera: Apidae) from northeastern Brazil by morphogeometric analysis
Authors: Araujo Edilson Divino de , Pinto Hanna Angélica Santos , Silva Wilson Romão Toledo da , Nunes Lorena Andrade 
Published: August 2023

This study investigated the morphometric variation in Melipona scutellaris stingless bees rational hive boxes from five states, inserted into the natural range of the species occurrence in northeastern Brazil. The cluster analysis (UPGMA) showed three distinct groups by determining the cutoff point. The multivariate analysis were performed using MANOVA and Canonical Variables for the shape analysis. The One-Way ANOVA was used to assess differences in centroid size. The results showed population divergence between localities limited by geographical barriers or great distances, corroborating previous observations by the UPGMA. Variation between colonies inter-state was higher that intra-state and, in most cases, Geometric Morphometrics was effective in identifying the origin of colonies transported to other states, observed in the cross-validation analysis that showed more than 70% of classification accuracy. Geometric Morphometrics could be used to evaluate the introduction of colonies within the kindred meliponary. Natural populations of Melipona scutellaris show a significant variation, which brings important implications to meliponiculture and to conservation strategies for this endangered species.
Analytical study on the atmospheric absorption properties of fiber lasers in a 1  µm band
Authors: Su Ang , Xu Xiaojun , Sun Quan , Ning Yu , He Yulong , Xi Fengjie 
Published: August 2023

Atmospheric absorption is one of the significant factors influencing the atmospheric propagation efficiency of high-power fiber lasers. Based on typical atmospheric environment parameters, the atmospheric absorption (aerosol and atmospheric molecular absorption) of fiber lasers with different linewidths and center wavelengths in a near 1 µm band is numerically calculated. The results show that the atmospheric absorption of common (several nanometer scales) and narrow linewidth (<1nm scale) lasers have distinctly different external characteristics, but the intrinsic mechanisms are interconnected. Due to the high wavelength selectivity of atmospheric molecular absorption, this work focuses on the factors influencing water vapor (main absorbing gas) absorption of different linewidth lasers and the corresponding low absorption region. Based on the fine atmospheric absorption spectra of different types of fiber lasers, the output spectra of fiber lasers can be artificially designed to avoid strong absorption during atmospheric propagation and achieve improved high-energy laser propagation efficiency. The above method provides a partial reference for designing and optimizing the light source parameters of high-power fiber lasers for atmospheric propagation.
Annäherungen an die Bedeutung und Funktion von šaḫūrū in altmesopotamischen Bauwerken
Authors: Schmitt Aaron 
Published: August 2023

Abstract
This paper discusses the written evidence for the word šaḫūru, which denotes a building or part of a building in Assyrian and Babylonian structures. A comparison of the textual evidence with the archaeological evidence from Aššur and Mari is used to consider the meaning and function of šaḫūru. Finally, it is discussed whether šaḫūru could have played a special role in the organization of festivals at the sites mentioned.
Artificial intelligence and posthumanist translation: ChatGPT versus the translator
Authors: Lee Tong King 
Published: August 2023

Abstract
Although automated translation has been available for decades in myriad forms, the implication of the current exponential advancement in artificial intelligence (AI) for communication in general and translation in particular is more starkly affrontational than ever. Although Large Language Models, of which ChatGPT is exemplary, were not specifically designed for translation purposes, they are attested to have attained a sufficient degree of technical sophistication as to generate translations that match or surpass dedicated translation systems in the market like Google Translate and DeepL. This impacts the modus operandi of communication and the self-concept of language professionals including, of course, translators. This article asks how translation as a field of practice can best respond to this development. It critically reflects on the implications of AI for the conception of translation, arguing that an alternative framing around the idea of distribution allows us to rescale translation toward broader competencies and conceive of AI as a prosthesis of translators’ minds. The article advocates a posthumanist perspective on translation with a view to expanding its spectrum of skills, modes, and media as well as transcending the traditional personae of translators.
Primary mediastinum Ewing’s sarcoma with pleural effusion: A case report and literature review
Authors: Li Xuhong , Qi Shan , Zhu Taiwen , Jiang Ying , Wang Wei 
Published: August 2023

Abstract
Ewing’s sarcoma (ES) is an aggressive cancer in young adults. Primary ES occurring in the chest with pleural effusion is even rarer. We report the case of a 15-year-old girl who presented with intermittent chest pain occurring for more than 2 months and cough and wheezing for 10 days. Radiological imaging showed a large soft tissue mass with multiple small vessel shadows near the left mediastinum and bloody pleural effusion in the left thorax. ES was diagnosed by positive immunostaining for CD99, FLI-1, and NKX2 combined with fluorescence in situ hybridization detection of the EWSR1 gene arrangement. With chemotherapy, lung computed tomography revealed that the tumor had become much smaller, and the fluid was absorbed. We report a case of extraskeletal Ewing’s sarcoma (EES) in the mediastinum with pleural effusion, which is unusual and challenging. EES is a highly malignant tumor with a poor prognosis. Early diagnosis and treatment can improve the survival rate of patients.