bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequence analysis and expression of the IRT1 gene under iron deficiency in amaranth (Amaranthus mangostanus L.)
Authors: Wang Yikun , Wang Kai , You Meng , Fan Hongli 
Published: July 2023

Abstract
Aims
Amaranth (Amaranthus mangostanus L.) is a hyperaccumulator that is effective in remediating soil cadmium (Cd) pollution. The iron-regulated transporter 1 (IRT1) gene, which encodes the iron (Fe) transporter protein, plays a crucial role in Cd uptake in plants, and its expression is induced by Fe deficiency. But its role in amaranth remains unknown.
Methods
In this study, the IRT1 gene from amaranth was cloned for sequence analysis and functional prediction using bioinformatics methods. A hydroponic experiment was performed to study amaranth Cd uptake and its expression under Fe deficiency with treatments of + Fe, −Fe, + Fe + Cd, and − Fe + Cd.
Results
A partial AmIRT1 cDNA sequence encoding 185 amino acids was obtained. Protein structure prediction revealed with almost the entire Pfam ZIP functional domain within the sequence. Functional prediction indicated that the protein was a transmembrane (TM) ion transporter with three TM domains. Using homology comparison and phylogenetic tree analysis, we found that the AmIRT1-encoded protein showed the highest homology with Arabidopsis IRT proteins and clustered with IRT proteins from other plants. The shoot and root Cd concentrations increased by 9.6% and 10.9%, respectively, in − Fe treatment compared with + Fe treatment. Cd accumulation was also observed to increase. Notably, AmIRT1 gene expression increased under both − Fe and − Fe + Cd treatments, but did not change under + Fe and + Fe + Cd treatments.
Conclusions
The structure and properties of the AmIRT1-encoded protein were similar to those of ZIP family members in other plants. Its expression can be increased by regulating Fe nutrition to improve amaranth Cd uptake.
STIGCN: Spatial-Temporal Interaction-aware Graph Convolution Network for Pedestrian Trajectory Prediction
Authors: Chen Wangxing , Sang Haifeng , Wang Jinyu , Zhao Zishan 
Published: July 2023

Abstract

Accurately predicting the future trajectory of pedestrians is critical for tasks such as autonomous driving and robot navigation. Previous methods for pedestrian trajectory prediction dealt with social interaction and pedestrian movement factors either concurrently or sequentially, neglecting the link between them. Therefore, a Spatial-Temporal Interaction-aware Graph Convolution Network (STIGCN) is proposed for pedestrian trajectory prediction. STIGCN considers the correlation between social interaction and pedestrian movement factors to achieve more accurate interaction modeling. Specifically, we first constructed spatial and temporal graphs to model social interactions and movement factors. Then, we designed the spatial-temporal interaction-aware learning to utilize the spatial interaction features of each moment to assist the temporal interaction modeling and utilize the temporal interaction features of each pedestrian to assist the spatial interaction modeling, resulting in more accurate interaction modeling. Finally, a Time-Extrapolator Pyramid Convolution Neural Network (TEP-CNN) is designed to jointly estimate the two-dimensional Gaussian distribution parameters of future trajectories by combining the prediction features from multiple layers. Experimental results on two benchmark pedestrian trajectory prediction datasets show that our proposed method outperforms existing methods in terms of average displacement error and final displacement error and achieves more accurate predictions for pedestrian motions such as convergence and encounter.
Enhancing Topic Prediction Using Machine Learning Techniques and ConceptNet-based Cosine Similarity Measure
Authors: Kaur Ashpreet , Singh Bhavneet , Nandi Basanti Pal , Jain Amita , Tayal Devendra Kumar 
Published: July 2023

Abstract
Topic modelling is one of the important research area of Natural Language Processing. Researchers have tried topic modelling for classification, categorization etc., and even the methods of topic modelling are used for sentiment analysis and other areas of language processing. In this paper, a novel method based on cosine similarity is used for topic modelling using Machine Learning Techniques. Cosine similarity measure on synonyms of topics present in the BBC News and Yahoo datasets from Concept Net is a pioneering approach. It has been observed that machine learning techniques applied here enhance accuracy compared to previously applied methods on these two datasets. On Yahoo datasets, the proposed technique increases the accuracy by 8% even over deep learning methods, which shows the efficiency and applicability of the research. Uses of ConceptNet is a novel idea over here, and the combination of ConceptNet with machine learning made the effort successful in comparison to existing state-of-the-art research on topic modelling.
Optimization of Antioxidant and Antimicrobial Activities by Fractionation of
Artemisia judaica subsp. sahariensis Crude Extract from Ahaggar (Algerian
Arid Region): UPLC-ESI-MS/MS Analysis of Fractions
Authors: Kebbab Ryma , basseddik Aida , Boussebaa Walid , Nabti Elhafid , Houali Karim 
Published: July 2023

Background:
In recent years, medicinal plants have received considerable attention due
to the search for novel bioactive compounds. In this optic, we have been interested in Artemisia
judaica subsp. sahariensis, a Saharan species widely used in phytotherapy by the Tuaregs of the
Ahaggar.

Objective:
This study aims to evaluate and optimize the biological activities of this plant in order
to valorize its bioactive compounds.

Methods:
For this purpose, an extraction with methanol (70%) was carried out, then a liquid-liquid
fractionation, using solvents with increasing polarity: diethyl ether, ethyl acetate, n-butanol and
water. We realized an analysis of phenols, flavonoids and evaluation of antioxidant and antimicrobial
activities in addition to the UPLC-ESI-MS/MS analysis of the fractions.

Results:
The reducing effect was proportional to the solvent polarity. The crude extract gave the
best reducing power (17.55 ± 3.06 μg/mL), better phenols and flavonoids contents (20.35 ± 0.5
mgGAE/gTDM), (10.35 ± 0.56 mgGAE/gTDM) respectively compared to its fractions. The DPPH
(2,2-Diphenyl-1-Picrylhydrazyl) radical scavenging assay showed that the ethyl acetate fraction
was the most active with the lowest IC50 value (inhibitory concentration to 50% of DPPH) (41.43
± 0.24 μg/ml) followed by n-butanol (58.53 ± 0.20 μg/mL), diethyl ether (135.07 ± 6.18 μg/mL)
and aqueous (226.41 ± 1.51 μg/mL) fractions (p <0.0001). Moreover, hydromethanolic extract gave
an IC50 value of 114.05 ± 3.37 μg/mL. The antimicrobial effect was observed on all clinical multiresistant
bacteria tested except Klebsiella pneumoniae, which was resistant. The most important
effect was observed by the ethyl acetate fraction against the fungal strain Candida albicans. Various
phenolic acids and flavonoids (flavones, flavonols, flavanones) were detected and could be responsible
for these bioactivities.

Conclusion:
We can conclude that liquid-liquid extraction with solvents of increasing polarity
plays a major role in optimizing the biological activity of this plant, which contains polyphenols
and can therefore be valued as a source of natural antioxidants and antimicrobials.
Saccopetalum tomentosum: Review of Its Botany, Medicinal Uses, Pharmacological Activities and Phytochemistry
Authors: Kumar Prashant , Shukla Karunakar 
Published: July 2023

Green medicine, or pharmaceuticals made from plants, has gained widespread interest since they are thought to be more trustworthy and safe than expensive synthetic drugs with side effects. Miliusa species include Saccopetalum tomentosum (S. tomentosum). Plants of S. tomentosum are abundant in tropical and subtropical areas, particularly in mainland Asia. In examining phytochemical and pharmacological features, more than ten Miliusa species were highlighted. S. tomentosum from Vietnam, Taiwan, and China was one of the main targets for phytochemical research. The isolation of numerous secondary metabolites has been successful. Alkaloids, flavonoids, terpenoids, styryls, and lactones are just a few of the chemical components obtained from S. tomentosum, but serial new derivatives of geranylated homogentisic acid may serve as biomarkers for differentiating Miliusa species. Simple, alternating, ovate, pubescent to glabrous, membranous leaves. Flowers solitary, fascicled or in cymes, extra-axillary or axillary, with oval or obovate bracts, monoecious, dioecious, or occasionally polygamous. Three sepals, valvate, Petals are arranged in two series, six in total, and are valvate in the buds. The outer petals resemble sepals in size and shape, while the inner petals are larger and thinner. Anthers are globose and extrorse, the connectives are slightly apiculate, and the stamens can be definite or indeterminate. Ovules 1–10, stigma club-shaped, style often short, and carpels indefinitely linear-oblong in shape. Numerous, stalked or subsessile, ovoid or rectangular, ripe carpels 1-2 or more seeds.
Keywords: S. tomentosum, Phytochemistry, Pharmacological activity, Ayurveda, Medicinal uses
Carbon Emission Reduction Effect of Digital Infrastructure: From the “Broadband China” Strategy
Authors: Feng Yao , Li Lu , Chen Hong 
Published: July 2023

Abstract
The establishment of digital infrastructure embodies a pivotal instrument in propelling developmental metamorphosis, whilst fostering energy preservation and emission abatement. By employing municipal-level data spanning the period from 2009 to 2019, this research establishes a quasi-natural experiment anchored upon the “Broadband China” strategy. Employing the Difference-in-Differences (DID) methodology, this inquiry thoroughly examines the influence of digital infrastructure construction on the alleviation of carbon emissions. The findings indicate that the implementation of digital infrastructure exerts a notable impact on the reduction of carbon emissions. Moreover, carbon emission reduction resulting from digital infrastructure construction exhibits distinctive characteristics of heterogeneity. The empirical evidence presented within this study serves as a fundamental cornerstone for attaining the objectives of carbon peaking and carbon neutrality.
O uso de psilocibina é eficaz no tratamento de depressão?
Authors: Filho Edson Santana Gois , Reis Ana Letícia Fiscina , De Farias Marco Antônio Galvão Martins , Fonseca João Pedro Carvalho , Clímaco Rafael Silva , Campos Rafael Baquit 
Published: July 2023

Os Inibidores da Recaptação de Serotonina (ISRS) foram descobertos na década de 1980 e, desde então, são a primeira linha para o tratamento da depressão. Nos últimos anos, pesquisas para busca de novas terapias farmacológicas vem tomando visibilidade com a descoberta dos efeitos antidepressivos dos psicodélicos. Dentro deles, destaca-se a Psilocibina, um alcalóide advindo do fungo Psilocybe spp., que apresenta ação agonista do receptor serotoninérgico 5-HT2A e mostrou-se eficaz na melhora do quadro de pacientes que sofrem de depressão.
INSTRUMENTO PARA TELEFARMÁCIA NO AUTOCUIDADO APOIADO EM PESSOAS COM DIABETES: ESTUDO PILOTO
Authors: Queiroz Reijane Mara Pinheiro , De Sousa Ítalo Nunes Arrais , Ponte Junior Clayton Cardoso , De Souza Nívia Tavares Pessoa , Romero Nirla Rodrigues , Cavaco Afonso Miguel das Neves , Fonteles Marta Maria de França 
Published: July 2023

Objetivo: Descrever, com análise, os resultados de um estudo piloto, no desenvolvimento de um instrumento sistematizado (Formulário guia), para o acompanhamento de pessoas com diabetes de alto risco, na telefarmácia. Métodos: Trata-se de um estudo transversal, descritivo, envolvendo uma população de 342 pessoas com diabetes. O instrumento foi desenvolvido através de um workshop colaborativo envolvendo pesquisadores, gestão e representantes do serviço e aperfeiçoado utilizando as diretrizes e evidências para o diabetes e seu controle. Constituiu-se em duas partes, a primeira: contendo dados sociodemográficos e clínicos. A segunda, envolveu três fases: inicial, exploração e encerramento. Aspectos éticos foram contemplados e aprovados. Resultados: A amostra foi composta, em sua maioria, de mulheres (n=253;73,9%) e, quando comparadas aos homens, apresentaram maior risco para colesterol total alto (OR = 1,755; 95% IC [1,027-3,053]; P= 0,04024), e HDL baixo (OR = 1,833, 95% IC [1,076 - 3,116], P = 0,0233*). As orientações mais frequentes foram a adequação do exercício físico e o cuidado com a administração dos medicamentos para diabetes. Conclusão: O Formulário guia permitiu identificar as barreiras enfrentadas pelos pacientes, e facilitou a tomada de decisão dos farmacêuticos no período da pandemia.
Formação quadrirradiculada da veia porta - hepatica: um achado raro de variação anatômica e sua importância clínico-cirúrgica
Authors: Da Silva Ivan do Nascimento , Ramalho Antônio José Casado , Barbosa Fabiano Timbó , Rodrigues Célio Fernando de Sousa 
Published: July 2023

Introdução: Há uma significante quantidade de variações na formação da veia porta, tendo em algumas ocasiões a presença de mais veias, sendo os dados da literatura conflitantes sobre essas frequentes variações anatômicas dos vasos que formam o sistema portal Objetivo: Descrever uma variação na formação da veia porta de um cadáver do laboratório de Anatomia Humana. Material e método: Trata-se de um relato de caso evidenciado durante a dissecção do compartimento supramesocólico do abdome de um cadáver do sexo masculino fixado em glicerina, pertencente ao laboratório do Centro Universitário Tiradentes – AL, foi observado a presença de uma variação na formação da veia porta hepática. Resultado: A variação encontrada se trata de uma veia porta formada quadrirradicularmente. Conclusão: Embora a variação encontrada neste relato seja a mais rara por ser quadrirradicular, não existindo imagens em livros e artigos, apenas comentários sobre a possibilidade de sua ocorrência, seu conhecimento faz-se relevante, sobretudo por parte dos cirurgiões.
How time gets spatial: factors determining the stability and instability of the mental time line
Authors: Scozia Gabriele , Pinto Mario , Pellegrino Michele , Lozito Silvana , Pia Lorenzo , Lasaponara Stefano , Doricchi Fabrizio 
Published: July 2023

AbstractLeft-to-right readers classify faster past events with motor responses on the left side of space and future events with responses on the right side. This suggests a left-to-right spatial organization in the mental representation of time. Here, we show that the significance and reliability of this representation are linked to the joint use of temporal and spatial codes in the task at hand. In a first unimanual Go/No-Go Implicit Association Test (IAT), attending selectively to “past” or to “future” words did not activate corresponding “left” or “right” spatial concepts and vice versa. In a second IAT, attending to both temporal (i.e., “past” and “future”) words and spatial targets (i.e., “left” and “right”) pointing arrows produced faster responses for congruent rather than incongruent combinations of temporal and spatial concepts in task instructions (e.g., congruent = “Go with past words and left-pointing arrows”; incongruent = “Go with past words and right-pointing arrows”). This effect increased markedly in a STEARC task where spatial codes defined the selection between “left-side” and “right-side” button presses that were associated with “past” and “future” words. Two control experiments showed only partial or unreliable space–time congruency effects when (a) participants attended to superordinate semantic codes that included both spatial “left”/”right” or temporal “past/future” subordinate codes; (b) a primary speeded response was assigned to one dimension (e.g., “past vs. future”) and a nonspeeded one to the other dimension (e.g., “left” vs. “right”). These results help to define the conditions that trigger a stable and reliable spatial representation of time-related concepts.
The Way of Water: ALMA Resolves H2O Emission Lines in a Strongly Lensed Dusty Star-forming Galaxy at z ∼ 3.1
Authors: Perrotta Francesca , Giulietti Marika , Massardi Marcella , Gandolfi Giovanni , Ronconi Tommaso , Zanchettin Maria Vittoria , Amato Quirino D’ , Behiri Meriem , Torsello Martina , Gabrielli Francesco , Boco Lumen , Galluzzi Vincenzo , Lapi Andrea 
Published: July 2023

Abstract
We report Atacama Large Millimeter/submillimeter Array (ALMA) high-resolution (≲0.3″) observations of water emission lines p-H2O(202 − 111), o-H2O(321 − 312), p-H2O(422 − 413), in the strongly lensed galaxy HATLASJ113526.2-01460 at redshift z ∼3.1. From the lensing-reconstructed maps of water emission and line profiles, we infer the general physical properties of the interstellar medium (ISM) in the molecular clouds where the lines arise. We find that the water vapor lines o-H2O(321 − 312), p-H2O(422 − 413) are mainly excited by far-infrared (FIR) pumping from dust radiation in a warm and dense environment, with dust temperatures ranging from 70 to ∼100 K, as suggested by the line ratios. The p-H2O(202 − 111) line, instead, is excited by a complex interplay between FIR pumping and collisional excitation in the dense core of the star-forming region. This scenario is also supported by the detection of the medium-level excitation of CO resulting in the line emission CO (J = 8–7). Thanks to the unprecedented high resolution offered by the combination of ALMA capabilities and gravitational lensing, we discern the different phases of the ISM and locate the hot molecular clouds into a physical scale of ∼500 pc. We discuss the possibility of J1135 hosting an active galactic nucleus in its accretion phase. Finally, we determine the relation between the water emission lines and the total IR luminosity of J1135, as well as the star formation rate as a function of water emission intensities, comparing the outcomes to local and high-z galactic samples from the literature.
The Planetary Accretion Shock. III. Smoothing-free 2.5D Simulations and Calculation of Hα Emission
Authors: Marleau Gabriel-Dominique , Kuiper Rolf , Béthune William , Mordasini Christoph 
Published: July 2023

Abstract
Surveys have looked for Hα emission from accreting gas giants but found very few objects. Analyses of the detections and nondetections have assumed that the entire gas flow feeding the planet is in radial freefall. However, hydrodynamical simulations suggest that this is far from reality. We calculate the Hα emission from multidimensional accretion onto a gas giant, following the gas flow from Hill sphere scales down to the circumplanetary disk (CPD) and the planetary surface. We perform azimuthally symmetric radiation hydrodynamics simulations around the planet and use modern tabulated gas and dust opacities. Crucially, contrasting with most previous simulations, we do not smooth the gravitational potential but do follow the flow down to the planetary surface, where grid cells are 0.01 Jupiter radii small. We find that roughly only 1% of the net gas inflow into the Hill sphere directly reaches the planet. As expected for ballistic infall trajectories, most of the gas falls at too large a distance on the CPD to generate Hα. Including radiation transport removes the high-velocity subsurface flow previously seen in hydrodynamics-only simulations, so that only the free planet surface and the inner regions of the CPD emit substantial Hα. Unless magnetospheric accretion, which we neglect here, additionally produces Hα, the corresponding Hα production efficiency is much smaller than usually assumed, which needs to be taken into account when analyzing (non)detection statistics.
Lateral Confinement and the Remarkably Self-similar Nature of Coronal Pseudostreamer Mass Ejections
Authors: Wang Y.-M. , Hess P. 
Published: July 2023

Abstract
Coronal mass ejections (CMEs) that originate from pseudostreamers, which separate coronal holes of the same magnetic polarity, are characterized by a narrow (∼5°–30°), fan-shaped appearance in white-light coronagraph images. Despite this striking morphological similarity, a wide variety of underlying eruptions are observed, including not only coronal jets, but also larger-scale filament eruptions, footpoint flares, and even extreme-ultraviolet (EUV) waves that reflect off the coronal hole boundaries. Using EUV images recorded by the Solar Dynamics Observatory during the early rising phase of cycle 25 (2020–2022), we describe examples of the different kinds of underlying eruptions and identify the corresponding fan-like ejections in Large Angle and Spectrometric Coronagraph images. We attribute the narrowness of the white-light CMEs to lateral confinement by the like-polarity open flux surrounding the pseudostreamer and point out that, although the multipolar topology facilitates the “breakout” of material through the cusp region, it also tends to inhibit the eruption of the pseudostreamer as a whole. We also note that the self-similar “continuum” formed by the pseudostreamer mass ejections does not include the larger, more space-weather-effective CMEs associated with helmet streamers, which are surrounded by open flux of opposite polarity and undergo much greater lateral expansion.
The Density Parity Model for the Evolution of the Subhalo Inner Spin Alignments with the Cosmic Web
Authors: Moon Jun-Sung , Lee Jounghun 
Published: July 2023

Abstract
We develop a new model within which the radius-dependent transition of the subhalo inner spins with respect to the cosmic web and the variation of the transition threshold radius (r
th) with subhalo mass (M
vir), smoothing scale (r

f
), and redshift (z) can be coherently explained. The key tenet of this model is that the competition between the pressure effect of the inner mass and the compression effect of the local tidal field determines which principal direction of the tidal field the inner spins are aligned with. If the former predominates, then only the tidal torques turn on, resulting in the alignments of the inner spins with the intermediate principal axes of the tidal field. Otherwise, the subhalo spins acquire a tendency to be aligned with the shortest axes of the subhalo shapes, which is in the major principal directions of the tidal field. Quantifying the two effects in terms of the densities, we make a purely analytical prediction for r
th (M
vir, z, r

f
). Testing this model against the numerical results from a high-resolution dark-matter-only N-body simulation in the redshift range of 0 ≤ z ≤ 3 on the galactic mass scale of

11.8
≤
log

M

vir

/

(

h

−
1

M

⊙

)
≤
12.6

for two different cases of r

f

/(h
-1 Mpc)

= 0.5 and 1, we find excellent agreements of the model predictions with the numerical results. It is also shown that this model naturally predicts the alignments between the inner spins of the present subhalos with the principal axes of the high-z tidal field at the progenitors’ locations.