bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of cannabidiol in modulating chronic neuropathic orofacial pain
Authors: Lee Ronan , Renton Tara 
Published: June 2023

Chronic neuropathic orofacial pain is an extremely debilitating disorder that poses a burden to patients as well as the economy. Although a common condition, the management and treatment for those affected remains limited. Cannabidiol is a safe, non-psychoactive compound derived from the Cannabis sativa plant, which possesses properties that can modulate pain, including anti-neuropathic, anti-nociception and anti-inflammatory capacities. Although research is limited, cannabidiol may be able to treat chronic orofacial pain in some neurological, neurovascular and idiopathic conditions. This article aims to increase awareness of cannabidiol, and its possible use for future treatment of chronic neuropathic orofacial pain.CPD/Clinical Relevance: Cannabidiol may be useful as a treatment for chronic neuropathic orofacial pain.
When Occam's razor loses its edge: the simplest explanation isn't always correct
Authors: Hennigan Máiréad , Henderson Simon , Burke Ezra 
Published: June 2023

Dental infections are common in children. Occam's razor, typically paraphrased, suggests that the simplest solution is most likely the right one. We report a case of an 11-year-old child who presented with right-sided facial swelling, fever, trismus, and a heavily broken-down right maxillary molar with a large apical radiolucency. After admitting the child, intravenous antibiotics and fluids were prescribed in preparation for the extraction of the UR6 and LR6 in theatre early the next morning. However, 9 hours later, before surgery, the patient unexpectedly and rapidly deteriorated neurologically. MRI and CT examination revealed a diagnosis of a subdural empyema. This emergency was managed with a multidisciplinary team, involving neurosurgeons, oral and maxillofacial surgeons, otolaryngologists, and radiologists. The case highlights the importance of not assuming that the simplest diagnosis is always the only, or most appropriate, one to make. CPD/Clinical Relevance: Regarding patients with a facial swelling, high order thinking may be required in clinical diagnosis.
Elizabeth Elstob and the Printing of Anglo-Saxon
Authors: Lucas Peter J. 
Published: June 2023

Abstract
Elizabeth Elstob, known as “the Saxon nymph”, is much celebrated for her publications on Old English, Ælfric’s homily on St Gregory (1709), for example. Her Rudiments of Grammar for the English-Saxon Tongue (1715) was the first AngloSaxon grammar in English. It was also notable for introducing a new printing fount for Anglo-Saxon, one that reproduced almost every letter in an authentic imitation of that found in Anglo-Saxon manuscripts, the first fount to attempt this degree of authenticity. This paper explores Elizabeth Elstob’s publishing career through the medium of the means (and difficulties) of printing Anglo-Saxon. It also draws attention to another manuscript in Elizabeth Elstob’s hand that is not generally known.
Grenzen der Virtualisierung?
Authors: Kleemann Frank , Leontaris Timo 
Published: June 2023

Zusammenfassung
Seit Beginn der Corona-Pandemie wird immer mehr Arbeit (zumindest anteilig) ortsungebunden außerhalb des Betriebs verrichtet, eine Tendenz, die aller Voraussicht nach auch in Zukunft bestehen bleiben wird. Der vorliegende Beitrag untersucht auf der Grundlage narrationsorientierter Interviews mit Universitätsangehörigen, wie sich die Kommunikation von Bürobeschäftigten durch eine zunehmende räumliche Distanz zwischen diesen gewandelt hat. Der Beitrag skizziert die Funktionalität von (teil)virtualisierter Kommunikation sowie die Veränderungen, die sich für arbeitsbezogenen sowie informellen Austausch zwischen Beschäftigten ergeben. Die Befunde verweisen auf wesentliche Veränderungen der kollaborativen Arbeitspraxis: Sowohl arbeitsprozessbezogene als auch informelle Kommunikation werden ausgedünnt, was im Ergebnis zu einer stärker individualisierten Praxis des Arbeitens sowie einer zunehmenden zwischenmenschlichen Distanz in virtuellen Arbeitssettings führt.
Dritte Arbeitsorte auf dem Prüfstand
Authors: Klatt Rüdiger , Steinberg Silke 
Published: June 2023

Zusammenfassung
Im Rahmen eines Feldexperiments konnten im Projekt CoWin Berufspendler*innen über einen Zeitraum von 27 Monaten (September 2018 bis Dezember 2020) das neue Arbeitsmodell Coworking im Realbetrieb testen und mitgestalten. Untersucht wurde, welche Potenziale, aber auch welche Barrieren und Herausforderungen (z.B. in Bezug auf Personal und Organisationsstrukturen) sich für Unternehmen und Beschäftigte durch dezentrale Arbeitsorganisationen unter Einbindung von Coworking-Spaces ergeben. Es zeigte sich dabei, dass bislang offenbar nur wenige Unternehmen und Beschäftigte das strategische Potenzial einer (weiteren) Dezentralisierung von Arbeit erkennen und angemessen im Hinblick auf eine bessere Arbeitsqualität begleiten. Viele Beschäftigte etwa werden, so die These, nicht systematisch darauf vorbereitet, die Potenziale des Arbeitsmodells Coworking in Bezug auf eine bessere Arbeitsqualität und im Hinblick auf die Schonung individueller und kollektiver Ressourcen auszureizen.
Investigation of erosion wear performance and mechanism of mold materials
Authors: Jiang Ben , Zhai Ming 
Published: June 2023

Abstract
The surface of an injection mold is prone to erosion and wear under the impact of the filler during plastics injection molding, which leads to premature failure of the mold. The mechanism of erosion and wear of a filler on the mold has not been clarified yet. A numerical technique was employed to simulate the erosion and wear process, and the influence of environmental parameters and particle characteristics, such as erosion velocity, erosion angle, temperature, and particle shape were studied. The results showed that the erosion velocity and erosion angle are important factors that affect erosion and wear. Finally, the relationship between change of particle energy and erosion and wear of the material is studied from the perspective of energy.
Enhancing Cinema Experience for Visually Impaired Persons in China: A Case Study on Shenzhen
Authors: Ye Zi , Jie Huamei 
Published: June 2023

Abstract
Film is an essential medium through which people access information and participate in cultural activities. However, it is not equally accessible to everyone. In China, some visually impaired persons (VIPs) benefit from “barrier-free films” (无障碍电影, Wuzhang’ai Dianying), which help them access films through audio description (AD). AD provides oral descriptions of visual information without disturbing the original dialogue. China’s barrier-free film industry is progressing but remains at a preliminary stage, leaving potential deficiencies in VIPs’ film-watching experience. Relevant literature is scarce and often written in Chinese, constituting a barrier to connections with the international accessibility research community. Here, Shenzhen is used as an example to develop a holistic view of the status of China’s barrier-free film industry. Problems in the quantity, quality, physical facilities, and virtual services involved in AD are identified and recommendations regarding operating modes, accessibility training, and screening channels are proposed.
Vitamin A and vitamin D3 protect the visual apparatus during the development of dopamine-2 receptor knockout mouse model of Parkinsonism
Authors: Umar Mujittapha Sirajo , Ibrahim Badamasi Muhammed 
Published: June 2023

Abstract

Objectives
Dopamine-related movement disorders are associated with a loss of visual acuity. Studies have shown that chemical stimulation of the vitamin D3 receptor (VDR) ameliorates movement disorders; however, the chemical stimulation is not effective when there is a deficiency of vitamin A in the cells. In the study, we examine the role of VDR and its interplay with vitamin A in impaired visual function in the dopamine deficit model.

Methods
Thirty (30) male mice with an average weight of 26 g ± (2) were divided into six group (NS,−D2,−D2 + VD D2 + VD, −D2 + VA, −D2 + (VD + VA) and −D2 + D2 groups). Dopamine deficit models of movement disorders were created using 15 mg/kg of haloperidol (−D2) injected intraperitoneally daily for 21 days. In the −D2 + (VD + VA) group, 800 IU/day of vitamin D3 (VD) and 1000 IU/day of vitamin A were concurrently used, while in the −D2 + D2 group, bromocriptine (+D2) was used as the standard treatment of the model. At the end of the treatment phase, the animals were subjected to visual water box test for visual acuity. The level of oxidative stress was measured using Superoxide dismutase (SOD) and malondialdehyde (MDA) in the retina and visual cortex. The level of cytotoxicity in these tissues was measured using Lactate dehydrogenase (LDH) assay, while the structural integrity of these tissues was assessed using a light microscope by assessing slide mounted sections that were stained with haematoxylin and eosin.

Results
A significant decline in time taken to reach the escape platform in the visual water box test was observed in the −D2 (p<0.005) and −D2 + D2 (p<0.05) group. In the retina and the visual cortex, a significant increase in LDH, MDA and the density of degenerating neurons was observed in the −D2 and −D2 + D2 groups. LDH level in the retina was also found to be significantly increased in (−D2 + VD, −D2 + VA, −D2 + (VD + VA). A Significant decrease in SOD was found in the retina and visual cortex of −D2 and −D2 + D2 group. In the histology of the retina, thinning of the retina, retinal fold, distortion and retinal detachment were all seen in the −D2 group. These structural alterations were not seen in other groups. Histological hallmarks of degeneration were observed in the visual cortex of the mice from the −D2 (p<0.001), −D2 + D2 (p<0.005) and −D2 + VD (p<0.05) groups only.

Conclusions
Dopamine-deficient models of movement disorders are associated with loss of visual functions, especially due to thinning of the retina, retinal fold, retinal detachment, and neurodegeneration in the visual cortex. Supplementation during the development of the model with vitamin D3 and vitamin A prevented the deterioration of the retina and visual cortex by reducing the degree of oxidative stress and cytotoxicity.
The influence of semantic predictability on transposition effects in Chinese and English
Authors: Wang Feng , Jia Guanjie , Wang Yun 
Published: June 2023

Abstract
Semantic predictability is one of the important factors that influence word processing and recognition. Based on the SPaM paradigm (Self-paced reading + Masked priming), the present study explores the influence of semantic predictability on TL effects in Chinese and English. The findings show that in both languages, internal and final transpositions produce priming effect in low-predictability preceding and following contexts as well as in high-predictability following contexts. From the perspective of priming magnitude, internal transposition produces greater priming effect than final transposition in English, while in Chinese, final transposition produces greater priming effect than internal transposition. In high-predictability preceding contexts, internal and final transpositions reveal significant priming effect and initial transposition produces close-to-significant-level priming effect in English, while in Chinese, no significant priming effect is observed in initial, internal or final transpositions.
Beyond the smart city: a communications-led agenda for twentyfirst century cities
Authors: McQuire Scott 
Published: June 2023

Abstract
Digital media technologies, from networked sensors to large video screens and mobile devices, have become pervasive urban infrastructure in the twentyfirst century. The dominant framework for understanding the integration of digital technology into urban space has been smart city discourse. In this article, I will argue that this framework, as it has so far been articulated, is inadequate to maximizing the social potential of digital urban infrastructure. Digital urban infrastructure not only changes how cities look, but how they function as social settings. I will propose the ‘communicative city’ as an alternative framework for thinking about digitally mediated cities. The communicative city offers an opportunity to consider networked urban space as a test case in which key problematics of contemporary globalized media are materially instantiated. It is the frontier zone at which everyday experiences of embodied media and new forms of communicative agency collide with powerful logics of tracing and tracking, and the widespread deployment of new forms of automation and machine learning as techniques of urban governance.
State and university tensions in Baltic higher education language policy
Authors: Rozenvalde Kerttu , Klaas-Lang Birute , Mačianskienė Nemira 
Published: June 2023

Abstract
This article explores state and university language policy (LP) agents in Estonia, Latvia, and Lithuania to illuminate their relationship and standpoints in higher education language management. Being interested in who stands for what and whose positions are legitimised, we study the higher education LPs of each state, language principles of universities, and public debates. We conceptualise active LP agents as people with power, people with expertise, people with influence, and people with interest, and consider them to exercise agency in five stages: policy initiation, involvement, influence, intervention, and implementation. By means of argumentation analysis we examine the nature of agents together with the standpoints they express. The findings reveal the central role of most of the nationally oriented state policymakers in university language management in all three settings. Other state policymakers, university administrators, staff, and students become active agents when they disagree with the policies. Agents in each setting share the overarching policy goal, but the main difference of opinion that arises among them is about agency: Should the state or universities implement higher education LPs? And is the state capable of achieving the common policy goal when it takes the task upon itself?
The degradation behaviors of optical cellulose triacetate films in alkali/acid solutions
Authors: Wang Jian’an , Fan Xiushan 
Published: June 2023

Abstract
In this research, the degradation behaviors of ramie-based cellulose triacetate (CTA) films in alkali or acid solutions at room temperature were assessed. Moreover, the attenuated total reflection infrared (ATR-IR), physicochemical properties testing, scanning electron microscope (SEM), and thermogravimetric analysis/differential scanning calorimeter (TG/DSC) were employed to evaluate the detailed degradation process of the CTA films, which were treated by alkali or acidic aqueous solutions. The research results demonstrated that the dominant reaction of CTA films in NaOH solution with various concentrations is deacetylation. Intriguingly, the degradation behaviors of CTA films in HCl depend on the concentration of acid. The CTA films were almost immune to HCl with the concentration less than 1 mol L−1. However, films were degraded directly when the concentration of acid was higher than 1 mol L−1. This study provides a theoretical basis and further understanding for the treatment of dumped CTA films at room temperature.
Blue light-emitting diode of Er3+-doped borate glass for optoelectronics devices
Authors: Farag Mohammed A. , Abd-Allah Khalid , Turky Gamal M. , El-Okr Mohamed M. , Abu-raia Walid A. , Saeed Aly 
Published: June 2023

Abstract
A blue emitter of Er3+ ions doped a host glass of a chemical composition 30B2O3–30Bi2O3–20Li2O–10BaO–10PbO was fabricated to be used in optoelectronics devices. Four proposed concentrations of Er2O3, which are 0.5, 1, 2, and 4 mol%, were suggested to study the impact of Er3+ ions on the structural, thermal, and photoluminescence properties of the considered host glass, respectively. The phase checking of the produced glasses using X-ray diffraction patterns showed the amorphicity phase formation. Impact of Er3+ ions on the structural properties of the considered host glass network was extensively studied through the occurred variations in XRD patterns, density and density-based parameters, and FTIR spectra. Thermally, the considered glasses have high thermal stability and high glass formability. Optically, the optical band gap, which ranged between 2.18 and 2.56 eV, signifies that the considered glasses have a semiconducting nature. Under 540 nm excitation wavelength, three bands were emitted in the blue region at 450, 462, and 486 nm and two in the violet region at 412 and 427 nm. Chromaticity analysis through CIE 1931 chromaticity diagram showed a strong blue light emission from the produced glasses. The blue light color purity of the considered glasses ranged between 90.887 and 92.324 %. Hence, the considered glasses have suitable characteristics that make them a good choice as blue light-emitting diodes in the optoelectronics devices.
Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells
Authors: Ralston Brett A , Khan Lamia , DeVore Stanley B , Bronnenberg Trent A , Flock Joseph W , Sequoia Ari O , Thompson Paul R , Navratil Amy M , Cherrington Brian D 
Published: June 2023

In brief
DGCR8 microprocessor complex, which is important for miRNA biogenesis, is regulated by peptidylarginine deiminase 2 and expression fluctuates in gonadotrope cells across the mouse estrous cycle.

Abstract
Canonical miRNA biogenesis requires DGCR8 microprocessor complex subunit, which helps cleave pri-miRNAs into pre-miRNAs. Previous studies found that inhibiting peptidylarginine deiminase (PAD) enzyme activity results in increased DGCR8 expression. PADs are expressed in mouse gonadotrope cells, which play a central role in reproduction by synthesizing and secreting the luteinizing and follicle stimulating hormones. Given this, we tested whether inhibiting PADs alters expression of DGCR8, DROSHA, and DICER in the gonadotrope-derived LβT2 cell line. To test this, LβT2 cells were treated with vehicle or 1 µM pan-PAD inhibitor for 12 h. Our results show that PAD inhibition leads to an increase in DGCR8 mRNA and protein. To corroborate our results, dispersed mouse pituitaries were also treated with 1 µM pan-PAD inhibitor for 12 h which increases DGCR8 expression in gonadotropes. Since PADs epigenetically regulate gene expression, we hypothesized that histone citrullination alters Dgcr8 expression thereby affecting miRNA biogenesis. LβT2 samples were subjected to ChIP using an antibody to citrullinated histone H3, which shows that citrullinated histones are directly associated with Dgcr8. Next, we found that when DGCR8 expression is elevated in LβT2 cells, pri-miR-132 and -212 are reduced, while mature miR-132 and -212 are increased suggesting heightened miRNA biogenesis. In mouse gonadotropes, DGCR8 expression is higher in diestrus as compared to estrus, which is the inverse of PAD2 expression. Supporting this idea, treatment of ovariectomized mice with 17β-estradiol results in an increase in PAD2 expression in gonadotropes with a corresponding decrease in DGCR8. Collectively, our work suggests that PADs regulate DGCR8 expression leading to changes in miRNA biogenesis in gonadotropes.
CASO EICHMANN Y SUS EFECTOS CORRUPTORES EN LOS SISTEMAS GUBERNAMENTALES Y SOCIALES: UNA DISCUCIÓN INDISPENSABLE EN EL DERECHO PENAL
Authors: Vázquez Varela Froylán Francisco , Ferrari Ávila Rebeca Astrid 
Published: June 2023

Adolf Eichmann fue un general del ejército nazi que enjuiciaron por crímenes en el genocidio judío y condenado por la comunidad internacional, sin embargo, las teorías arendtinas de la banalidad del mal y de la vida activa, consideran que de una manera orgánica los individuos construyen las reglas morales en la sociedad y esta hace lo mismo con los individuos, pero en algunas ocasiones el contexto social puede ser causante de amoralida en los sujetos que delinquen.
Para el Derecho penal este tema es de suma relevancia, pues con fundamento en las mencionadas teorías se puede plantear la excusa de responsabilidad del delito en el supuesto de que los sujetos con conducta delictiva tuvieran tal distorsión de la realidad en el que no les adjudican un carácter moral a las leyes o las ordenes de los sistemas gubernamentales. Por ello, en la presente investigación se hace un estudio filosófico-jurídico sobre el problema del mal, en donde se retoma la postura de Hannah Arendt y Zygmunt Bauman para poner a discusión la probable adaptación de las leyes penales para que contemplen el efecto de la banalidad del mal o la ceguera moral en las sentencias.
Autoantibody Profile and Lung HRCT Scan in Systemic Sclerosis with Restrictive Lung Disease
Authors: Saragih Winda Agnestia Maranna , Dewi Sumartini , Wachjudi Rachmat Gunadi , Logito Verina , Tjandrawati Anna 
Published: June 2023

Objective: To identify auto-antibodies in systemic sclerosis with interstitial lung disease (ILD). Method: This was a descriptive categorical study on auto-antibody profile in systemic sclerosis patients visiting the Rheumatology Clinic of Dr. Hasan Sadikin General Hospital, West Java, and Bandung during the period of January 2018 to December 2019 who were registered in the West Java Systemic Sclerosis Registry. Auto-antibody identification was performed using the Euroline immunoblot assays.Results: Thirty six cases were identified during the study period with most of the cases involved women (n=35, 97.2%). The average age of patients participating in this study was 40 years, with an average duration of disease of 18 months. Diffuse cutaneous systemic sclerosis was found in 22 (61.1%) cases and limited cutaneous systemic sclerosis was observed in 14 (38.9%) cases. Specific autoantibodies were positive in 33 (91.6%) cases, with anti-topoisomerase I as the largest group, positive in 22 (52.9.3%) cases. This was followed by anti-Th/To in eight (15.7%) cases; anti-Ro52 in four (7.8%) cases; anti-centromere in three (5.9%) cases; anti-RNA polymerase in three (5.9%) cases; anti-fibrillarin in three (5.9%) cases; anti-Ku in two (3.9%) cases; and anti-PDGF in one (2.0%) case. High-resolution computed tomography of the lung showed 34 (94.4%) cases with ILD and 22 (61.1%) cases with severe lung fibrosis. Usual interstitial pneumonia was seen in 19 (52.8%) cases and non-specific interstitial pneumonia in 15 (41.7%) cases.Conclusion: Anti-topoisomerase I, anti-Th/To, and anti-Ro52 are the most common autoantibodies observed in systemic sclerosis patients with ILD as the most prevalent feature detected with lung HRCT.