bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salience and horizontal differentiation
Authors: Aytimur R. Emre 
Published: January 2023

AbstractI study a horizontal differentiation model in which one of two attributes of a product, product fit and price, is more salient for a consumer than the other and different consumers can find a different attribute salient. The attribute that is more salient is determined by relative differences between the two products and is determined endogenously as a result of firms' pricing strategies. High (low) marginal costs soften (toughen) price competition between firms. Pass‐through rates are greater than 1 for some parameter values. Both industry‐ and firm‐level cost increases may be beneficial for firms.
Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor
Authors: Amada Kohei , Hijiya Naoki , Ikarimoto Sawa , Yanagihara Kazuyoshi , Hanada Toshikatsu , Hidano Shinya , Kurogi Shusaku , Tsukamoto Yoshiyuki , Nakada Chisato , Kinoshita Keisuke , Hirashita Yuka , Uchida Tomohisa , Shin Toshitaka , Yada Kazuhiro , Hirashita Teijiro , Kobayashi Takashi , Murakami Kazunari , Inomata Masafumi , Shirao Kuniaki , Aoki Masahiro , Takekawa Mutsuhiro , Moriyama Masatsugu 
Published: January 2023

AbstractConstitutive activation of the mitogen‐activated protein kinase (MAPK) signaling pathway is essential for tumorigenesis of pancreatic ductal adenocarcinoma (PDAC). To date, however, almost all clinical trials of inhibitor targeting this pathway have failed to improve the outcome of patients with PDAC. We found that implanted MIA Paca2, a human PDAC cell line sensitive to a MAPK inhibitor, PD0325901, became refractory within a week after treatment. By comparing the expression profiles of MIA Paca2 before and after acquisition of the refractoriness to PD0325901, we identified clusterin (CLU) as a candidate gene involved. CLU was shown to be induced immediately after treatment with PD0325901 or expressed primarily in more than half of PDAC cell lines, enhancing cell viability by escaping from apoptosis. A combination of PD0325901 and CLU downregulation was found to synergistically or additively reduce the proliferation of PDAC cells. In surgically resected PDAC tissues, overexpression of CLU in cancer cells was observed immunohistochemically in approximately half of the cases studied. Collectively, our findings highlight the mechanisms responsible for the rapid refractory response to MEK inhibitor in PDAC cells, suggesting a novel therapeutic strategy that could be applicable to patients with PDAC using inhibitor targeting the MAPK signaling pathway and CLU.
Impact of salivary contamination during implant placement with different surface characteristics in native and augmented bone: An in vivo study in sheep calvaria model
Authors: Jinno Yohei , Stocchero Michele , Toia Marco , Papia Evaggelia , Ahmad Marianne , Becktor Jonas Peter 
Published: January 2023

AbstractObjectivesThe aim of this study was to evaluate whether salivary contamination during placement of implants with different surface characteristics affects osseointegration in native and in augmented bone areas.Materials and MethodsForty eight implants with machined surface (MS) and 48 implants with moderately rough surface (RS) were tested in the calvaria of 12 sheep. At the first surgery, 64 bony critical defects were randomly created and were subsequently augmented with two materials (autogenous or bovine bone). After 5 weeks of graft healing, 8 implants were placed per sheep, in native bone and in the centre of the augmented defects. Forty eight implants were soaked with saliva before placement (contaminated group [CG]), while 48 implants were not (non‐contaminated group [NCG]). Five weeks after implant placement, bone‐to‐implant contact (BIC) and bone material area fraction occupancy (BMAFO) were calculated histomorphometrically.ResultsSaliva contamination showed a significant negative effect (p = .000) on BIC, especially in augmented areas. RS showed significant positive effect on BIC, compared to MS (p = .000), while there were no significant differences for different bone conditions (p = .103). For BMAFO, the contamination showed a significantly negative affect (p = .000), while there were no significant differences for surface characteristics (p = .322) and for bone condition (p = .538).ConclusionSaliva contamination during dental implant placement has a negative effect on osseointegration in augmented areas. Moderately rough surface has a possible advantage in the aspect of initial bone to implant contact. However, it seems to be advisable to avoid saliva contamination especially for implants placed in augmented bone areas.
Effect of a novel interocclusal recording method on occlusal accuracy of implant‐supported fixed prostheses: A randomized clinical trial
Authors: Ding Qian , Pu Tingting , Tu Ya , He Mingzhu , Wang Shimin , Zhang Lei , Liu Jianzhang , Zhou Yongsheng 
Published: January 2023

AbstractObjectivesTo investigate the effect of a novel interocclusal recording method on the occlusal accuracy of implant‐supported fixed prostheses for partially dentate patients with distal extension.Materials and MethodsTwenty patients with two or more adjacent teeth missing in the distal extension and scheduled to receive implant‐supported fixed prostheses were enrolled. Two interocclusal recording methods were used: placing polyvinyl siloxane (PVS) on the interocclusal recording caps (test), and placing PVS on healing abutments (control). The intraoral occlusal contacts in maximal intercuspal position (MIP) were compared with those in the mounted casts to calculate sensitivity and positive predictive value (PPV). Then, patients were randomly allocated into two groups to determine which interocclusal record would be used. The implant prostheses' evaluations mainly included occlusal adjustment height, volume, and time, occlusal contact score based on articulating paper examination. Paired‐samples t‐test, Mann–Whitney U test, and least squares regression analyzed the statistic differences.ResultsThe test method had higher sensitivity to detect intraoral occlusal contacts than the control method (p = .002), but similar PPV (p = .10). During the prostheses' evaluations, the occlusal adjustment height in the test group was significantly lower than that in the control group [99.4 (53.2, 134.2) vs. 159.0 (82.3, 247.8) μm, p = .03], while the occlusal contact score before adjustment was higher (p = .006). The groups had similar occlusal adjustment volume and time.ConclusionsThe novel interocclusal recording method for implant‐supported fixed prostheses was more accurate and could reduce the occlusal adjustment.
A decrease in NR2B expression mediated by DNA hypermethylation induces perioperative neurocognitive disorder in aged mice
Authors: Xu Feifei , Cong Peilin , Zhang Bingqian , Dong Hailong , Zuo Wenqiang , Wu Tingmei , Tian Li , Xiong Lize 
Published: January 2023

AbstractAimsThis study was designed to investigate the role of NR2B and the contribution of DNA methylation to NR2B expression in the pathogenesis of PND.MethodsEighteen‐month‐old C57BL/6J mice were subjected to experimental laparotomy under 1.4% isoflurane anesthesia. Hippocampus‐dependent learning and memory were evaluated by using the Barnes maze and contextual fear conditioning tests. The protein and mRNA expression levels of NR2B were evaluated by western blotting and qRT–PCR respectively, and the methylation of the NR2B gene was examined by using targeted bisulfite sequencing. Long‐term synaptic plasticity (LTP) was measured by electrophysiology.ResultsMice that underwent laparotomy exhibited hippocampus‐dependent cognitive deficits accompanied by decreased NR2B expressions and LTP deficiency. The overexpression of NR2B in the dorsal hippocampus could improve learning and memory in mice subjected to laparotomy. In particular, the decreased NR2B expressions induced by laparotomy was attributed to the NR2B gene hypermethylation. Preoperative administration of S‐adenosylmethionine (SAM) could hypomethylate the NR2B gene, upregulate NR2B expression and improve LTP, exerting a dose‐dependent therapeutic effect against PND. Moreover, inhibiting NR2B abrogated the benefits of SAM pretreatment.ConclusionsLaparotomy cause hippocampus‐dependent cognitive decline by hypermethylating the NR2B gene, allowing us to understand the pathogenesis of PND in an epigenetic landscape.
Categories by which we try to live
Authors: Butler Judith 
Published: January 2023

AbstractCategories We Live By makes several claims about Judith Butler's Gender Trouble which Butler seeks to contest, while remaining in fundamental agreement with most of the conclusions in Asta Sveinsdottir's book. At issue is whether or not performativity can rightly be restricted to what is called an exercitive in J. L. Austin's sense, whether Butler is a radical constructivist or a qualified one, and whether unauthorized speech acts have a power to bring a reality into being that is different from those authorized by legal regimes. Along the way, Butler suggest that establishing facts takes place within variable historical schemes and that this argument is neither a denial or facts nor of materiality. Finally, an individualist idea of freedom is subject to criticism in order to make way for an historically constrained freedom, collective in nature.
Clinical presentation and management strategies of cardiovascular autonomic dysfunction following a COVID‐19 infection – A systematic review
Authors: Reis Carneiro Diogo , Rocha Isabel , Habek Mario , Helbok Raimund , Sellner Johann , Struhal Walter , Wenning Gregor , Fanciulli Alessandra 
Published: January 2023

AbstractBackgroundCardiovascular autonomic dysfunction may reportedly occur after a coronavirus‐disease‐2019 (COVID‐19) infection, but the available evidence is scattered. Here we sought to understand the acute and mid‐term effects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection on cardiovascular autonomic function.MethodsWe performed a systematic PubMed, Embase, Web of Science, medRxiv, and bioRxiv search for cases of cardiovascular autonomic dysfunction during an acute SARS‐CoV‐2 infection or post‐COVID‐19 condition. The clinical‐demographic characteristics of individuals in the acute versus post‐COVID‐19 phase were compared.ResultsWe screened 6470 titles and abstracts. Fifty‐four full‐length articles were included in the data synthesis. One‐hundred and thirty‐four cases were identified: 81 during the acute SARS‐CoV‐2 infection (24 thereof diagnosed by history) and 53 in the post‐COVID‐19 phase. Post‐COVID‐19 cases were younger than those with cardiovascular autonomic disturbances in the acute SARS‐CoV‐2 phase (42 vs. 51 years old, p = 0.002) and were more frequently women (68% vs. 49%, p = 0.034). Reflex syncope was the most common cardiovascular autonomic disorder in the acute phase (p = 0.008) and postural orthostatic tachycardia syndrome (POTS) the most frequent diagnosis in individuals with post‐COVID‐19 orthostatic complaints (p < 0.001). Full recovery was more frequent in individuals with acute versus post‐COVID‐19 onset of cardiovascular autonomic disturbances (43% vs. 15%, p = 0.002).ConclusionsThere is evidence from the scientific literature about different types of cardiovascular autonomic dysfunction developing during and after COVID‐19. More data about the prevalence of autonomic disorders associated with a SARS‐CoV‐2 infection are needed to quantify its impact on human health.
Nuptial pad (“breeding gland”) morphology is related to non‐random mating in wild male common frogs (Rana temporaria)
Authors: Orton Frances , Roberts‐Rhodes Bethany , Moore Emily , Whatley Catherine , Tyler Charles R. 
Published: January 2023

AbstractAndrogen levels are closely linked with breeding in male amphibians. Development of the nuptial pad is driven by androgens and is believed to have importance for determining mating success in anurans, but this has not been tested in wild populations. We investigated the association between nuptial pad morphology (length, colour) and mating (amplexus) success in wild male common frogs (Rana temporaria) in the UK (Devon in Southern England and central Scotland). Once active breeding had been confirmed, pond water (25 L) was placed in 1–6 replicate mesocosms (66 cm diameter circular, black plastic tubs) in situ. Eight male and two female frogs were placed into each mesocosm, and success observed by identifying the male frog(s) in amplexus. The length of nuptial pads for male frogs observed in amplexus was greater than those that did not achieve amplexus. There was no difference in the absolute dark colour of nuptial pads (determined by red/green/blue analysis, Adobe photoshop©) for male frogs observed in amplexus versus those that did not achieve amplexus. However, within each mesocosm, the nuptial pad was relatively darker for winning male frogs compared to losing male frogs. Overall, 91% of winning male frogs from Devon, and 89% winning male frogs from Scotland, possessed either a longer and/or a darker nuptial pad, compared with frogs that did not achieve amplexus. These data suggest that features of nuptial pad morphology are associated with amplexus (and thus mating) success in male common frogs. Given that nuptial pads have been identified in all anuran amphibian species analysed to date, nuptial pad morphology may contribute to non‐random mating strategies across a broad range of species.
The embeddedness and hidden political economy of the world heritage site inscription boom in China
Authors: Huang Kaixuan , Liu Yi 
Published: January 2023

AbstractSince the mid‐1980s, there has been a boom in world heritage site (WHS) inscriptions in China. Nevertheless, incumbent studies have not sufficiently explained why cities are enthusiastic about and capable of joining the boom. They tend to attribute such enthusiasm to the WHS values in heritage protection and tourism development. However, why stakeholders have motivations and opportunities to create the boom and what institutional environments support the craze are still yet to be answered. This paper investigates the boom through the concept of embeddedness to display how multi‐scalar institutional contexts in China stimulate and sustain WHS nomination. This study argues that the enthusiasm for WHS inscription is embedded in the political‐economic interests of stakeholders on different scales. At international and national levels, WHS nomination is regarded as a political tool to address diplomatic agendas, shape national honor, and balance regional development. On a local scale, WHS inscriptions can serve as a solid pretext for local states in China to fulfill their strong developmental imperatives and break financial constraints. These imperatives are embedded in China's transitional institutional environment, associated with power decentralization, central‐local fiscal rearrangements, and the top‐down system of cadre evaluation. In this context, local states are ambitious of initiating large‐scale development projects to boost local development. WHS nomination has become a pretext for local states to fulfill extraordinary development in tourism and other industries, such as the real estate industry. This study discloses the hidden political economy behind the WHS inscription boom using the cases of Wulingyuan and the South China Karst.
Synergistic activation of genes promoting invasiveness by dual deprivation in oxygen and nutrients
Authors: Jehanno Charly , Le Page Yann , Flouriot Gilles , Le Goff Pascale , Michel Denis 
Published: January 2023

AbstractBy depriving cancer cells of blood supplies of oxygen and nutrients, anti‐angiogenic therapy is aimed at simultaneously asphyxiating and starving the cells. But in spite of its apparent logic, this strategy is generally counterproductive over the long term as the treatment seems to elicit malignancy. Since a defect of blood supply is expected to deprive tumours simultaneously of oxygen and nutrients naturally, we examine here these two deprivations, alone or in combination, on the phenotype and signalling pathways of moderately aggressive MCF7 cancer cells. Each deprivation induces some aspects of the aggressive and migratory phenotypes through activating several pathways, including HIF1‐alpha as expected, but also SRF/MRTFA and TCF4/beta‐catenin. Strikingly, the dual deprivation has strong cooperative effects on the upregulation of genes increasing the metastatic potential, such as four and a half LIM domains 2 (FHL2) and HIF1A‐AS2 lncRNA, which have response elements for both pathways. Using anti‐angiogenic agents as monotherapy is therefore questionable as it may give falsely promising short‐term tumour regression, but could ultimately exacerbate aggressive phenotypes.
A bibliometric analysis of hidradenitis suppurativa literature over the past 50 years
Authors: Peles Galia , Horev Amir 
Published: January 2023

AbstractBackgroundWe aimed to describe the existing literature on hidradenitis suppurative (HS) in the last 50 years and the key processes made over time.MethodsOn July 27, 2022, we searched for HS studies published in the last 50 years (from 1972 to 2022) using Web of Science. The search was made using the keywords “Hidradenitis Suppurativa” and “Acne Inversa.” The data are subdivided according to publications and citations rate, country, publication year, journal and impact factor, keywords analysis of top 100 cited papers study design, and pediatric versus adults.ResultsIn total, 5072 documents were retrieved. The annual number of HS publications has increased over the years. The manuscript with the highest citation number was by Zouboulis et al., a total of 552 citations from 2015. The manuscript with the highest citation rate per year was by Mantovani et al., with a citation rate of 70.7/year. According to keywords analysis among the top 100 cited papers, most of the articles focused on management, followed by the pathogenesis of HS. Only 805 out of 5072 (15.8%) HS articles described the disease among children.ConclusionsIn the current analysis, we shed light on HS's transformations over the last 50 years. In addition, we described the 100 top cited papers and other essential characteristics not examined before, such as HS research in children, gender bias research, specific pharmacological therapy with keyword analysis, comorbidities, preventative care, and publications per country after controlling for population.
Integration of mental health and quality of life screening tools in an inflammatory bowel disease‐specific electronic medical record (Crohn Colitis Care): process and early outcomes
Authors: Lores Taryn , Krishnaprasad Krupa , Connor Susan J. , Cabaero Aura , Andrews Jane M. 
Published: January 2023

AbstractPsychological problems are prevalent in people with inflammatory bowel diseases but are not routinely addressed. To improve recognition, three psychological screening tools were integrated into clinical management software (Crohn Colitis Care). In the first 6 months, completion rates varied between participating sites, and approximately 23–34% of respondents scored in moderate or higher ranges for psychological distress. Evaluation of the clinical utility of the module to improve patient outcomes is recommended.
Analysis of dermoscopic changes of blue nevi on digital follow‐up: A 21‐year retrospective cohort study
Authors: Alamon‐Reig Francesc , Combalia Marc , Albero‐González Raquel , Alòs Llúcia , Carrera Cristina , Puig‐Butillé Joan Anton , Villanueva‐Cañas José Luis , Puig Susana , Malvehy Josep , Podlipnik Sebastian 
Published: January 2023

AbstractBackgroundBlue nevi are benign dermal melanocytic proliferations that are often easy to recognize clinically. Rarely, these lesions can display atypical features, suggesting the presence of a malignant blue nevus or mimicking cutaneous metastases of melanoma.ObjectiveTo describe the clinical evolution of blue nevi over time and to assess the need for monitoring these lesions.MethodsWe conducted a retrospective cohort study of 103 patients who were followed between December 1998 and November 2019. An artificial intelligence algorithm was used to identify blue nevi from the databases of two digital epiluminescence devices. Changes in the area of each lesion were calculated with a segmentation neural network.ResultsWe included 123 blue nevi from 103 patients. Most of the lesions segmented, 99 (91.7%), were considered stable. Of the 9 (8.3%) growing blue nevi identified, 2 (1.85%) showed significant growth. The studied growing blue nevi turned out to be cellular blue nevi, presented with a low tumour mutation burden and GNAQ c.626A>T alteration was identified in both lesions.LimitationsSome clinical variants of blue nevi might not be included.ConclusionsMost blue nevi remain stable during their evolution. Rarely, they can show progressive growth, although histopathological or molecular signs of malignancy have not been identified.
Confirmation of vehicle stability criteria through a combination of smoothed particle hydrodynamics and laboratory measurements
Authors: Azhar Fatima , Pauwels Valentijn R. N. , Bui Ha H. 
Published: January 2023

AbstractThis study combines laboratory experiments and numerical modelling in a novel manner to assess vehicle stability. Assessing vehicle stability forms the basis of hazard classification criteria, which in turn helps in forming safety guidelines for stream crossings and planning of evacuation routes in times of floods. These criteria are based on theoretical and physical model studies carried out on different vehicle models. This article demonstrates the application of a numerical method to determine the vehicle stability threshold so that the need for a physical model study for each kind of vehicle may be avoided. The numerical investigation is performed using smoothed particle hydrodynamics (SPH) with the vehicle oriented perpendicular to the flow direction, as this is the most critical orientation. A physical model study is also performed and its results are used to validate the SPH model. The results confirm the current Australian Rainfall and Runoff (ARR) safety criteria for stationary vehicles. It also suggests that the ARR stability curve can shift depending on the road conditions that affect the vehicle's sliding mechanism.
Fiscal Stimulus of Last Resort
Authors: Piergallini Alessandro 
Published: January 2023

AbstractI examine global dynamics in a monetary model with overlapping generations of finite‐horizon agents, nonseparable preferences over consumption and real money balances, and a binding lower bound on nominal interest rates. Debt targeting rules exacerbate the possibility of self‐fulfilling liquidity traps, for agents expect austerity following deflationary slumps. Conversely, activist but sustainable fiscal policy regimes—implementing intertemporally balanced tax cuts and/or transfer increases in response to disinflationary trajectories—are capable of escaping liquidity traps and embarking inflation into a globally stable path that converges to the target. Should fiscal stimulus of last resort be overly aggressive, however, spiral dynamics around the liquidity‐trap steady state exist, causing global indeterminacy.