bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impacts of diagnosis-intervention packet payment on the providers’ behavior of inpatient care—evidence from a national pilot city in China
Authors: Ding Yi , Yin Jia , Zheng Chao , Dixon Simon , Sun Qiang 
Published: June 2023

BackgroundIn 2020, the Chinese government developed and implemented an innovative case-based payment method under the regional global budget called the diagnosis-intervention packet (DIP) payment to pay for inpatient care. This study aims to assess the changes to inpatient care provision in hospitals after the DIP payment reform was implemented.MethodsThis study used inpatient medical costs per case, the proportion of the out-of-pocket (OOP) expenditure in inpatient medical costs, and the average length of stay (LOS) of inpatient care as outcome variables, and conducted an interrupted time series analysis to evaluate changes after the DIP payment reform. January 2021 was taken as the intervention point when a national pilot city of the DIP payment reform in the Shandong province began using the DIP payment to pay for inpatient care of secondary and tertiary hospitals. The data used in this study were obtained from the aggregated monthly claim data of inpatient care of secondary and tertiary hospitals.ResultsCompared to the pre-intervention trend, the inpatient medical costs per case, the proportion of the OOP expenditure in inpatient medical costs both in tertiary and secondary hospitals significantly decreased after the intervention. After the intervention, the reduction in the inpatient medical costs per case, the proportion of the OOP expenditure in inpatient medical costs in tertiary hospital were both higher than those in secondary hospital (p &lt; 0.001). The average LOS of inpatient care in secondary hospital significantly increased after the intervention, and it immediately increase 0.44 day after intervention (p = 0.211). Moreover, the change of average LOS of inpatient care in secondary hospital after intervention was opposite to that in tertiary hospital, it had no statistical difference (p = 0.269).ConclusionIn the short term, the DIP payment reform could not only effectively regulate provider behavior of inpatient care in hospitals, but also improves the rational allocation of the regional healthcare resources. However, the long-term effects of the DIP payment reform need to be investigated in the future.
The EPIDIA4Kids protocol for a digital epidemiology study on brain functioning in children, based on a multimodality biometry tool running on an unmodified tablet
Authors: Douet Vannucci Vanessa , Marchand Théo , Hennequin Alexandre , Caci Hervé , Staccini Pascal 
Published: June 2023

IntroductionNeurodevelopment and related mental disorders (NDDs) are one of the most frequent disabilities among young people. They have complex clinical phenotypes often associated with transnosographic dimensions, such as emotion dysregulation and executive dysfunction, that lead to adverse impacts in personal, social, academic, and occupational functioning. Strong overlap exists then across NDDs phenotypes that are challenging for diagnosis and therapeutic intervention. Recently, digital epidemiology uses the rapidly growing data streams from various devices to advance our understanding of health’s and disorders’ dynamics, both in individuals and the general population, once coupled with computational science. An alternative transdiagnostic approach using digital epidemiology may thus better help understanding brain functioning and hereby NDDs in the general population.ObjectiveThe EPIDIA4Kids study aims to propose and evaluate in children, a new transdiagnostic approach for brain functioning examination, combining AI-based multimodality biometry and clinical e-assessments on an unmodified tablet. We will examine this digital epidemiology approach in an ecological context through data-driven methods to characterize cognition, emotion, and behavior, and ultimately the potential of transdiagnostic models of NDDs for children in real-life practice.Methods and analysisThe EPIDIA4Kids is an uncontrolled open-label study. 786 participants will be recruited and enrolled if eligible: they are (1) aged 7 to 12 years and (2) are French speaker/reader; (3) have no severe intellectual deficiencies. Legal representative and children will complete online demographic, psychosocial and health assessments. During the same visit, children will perform additionally a paper/pencil neuro-assessments followed by a 30-min gamified assessment on a touch-screen tablet. Multi-stream data including questionnaires, video, audio, digit-tracking, will be collected, and the resulting multimodality biometrics will be generated using machine- and deep-learning algorithms. The trial will start in March 2023 and is expected to end by December 2024.DiscussionWe hypothesize that the biometrics and digital biomarkers will be capable of detecting early onset symptoms of neurodevelopment compared to paper-based screening while as or more accessible in real-life practice.
Impact of hearing aid technology level at first-fit on self-reported outcomes in patients with presbycusis: a randomized controlled trial
Authors: Houmøller Sabina Storbjerg , Wolff Anne , Tsai Li-Tang , Narayanan Sreeram Kaithali , Hougaard Dan Dupont , Gaihede Michael Lyhne , Neher Tobias , Godballe Christian , Schmidt Jesper Hvass 
Published: June 2023

To provide clinical guidance in hearing aid prescription for older adults with presbycusis, we investigated differences in self-reported hearing abilities and hearing aid effectiveness for premium or basic hearing aid users. Secondly, as an explorative analysis, we investigated if differences in gain prescription verified with real-ear measurements explain differences in self-reported outcomes. The study was designed as a randomized controlled trial in which the patients were blinded towards the purpose of the study. In total, 190 first-time hearing aid users (&gt;60 years of age) with symmetric bilateral presbycusis were fitted with either a premium or basic hearing aid. The randomization was stratified on age, sex, and word recognition score. Two outcome questionnaires were distributed: the International Outcome Inventory for Hearing Aids (IOI-HA) and the short form of the Speech, Spatial, and Qualities of Hearing Scale (SSQ-12). In addition, insertion gains were calculated from real-ear measurements at first-fit for all fitted hearing aids. Premium hearing aid users reported 0.7 (95%CI: 0.2; 1.1) scale points higher total SSQ-12 score per item and 0.8 (95%CI: 0.2; 1.4) scale points higher speech score per item, as well as 0.6 (95%CI: 0.2; 1.1) scale points higher qualities score compared to basic-feature hearing aid users. No significant differences in reported hearing aid effectiveness were found using the IOI-HA. Differences in the prescribed gain at 1 and 2 kHz were observed between premium and basic hearing aids within each company. Premium-feature devices yielded slightly better self-reported hearing abilities than basic-feature devices, but a statistically significant difference was only found in three out of seven outcome variables, and the effect was small. The generalizability of the study is limited to community-dwelling older adults with presbycusis. Thus, further research is needed for understanding the potential effects of hearing aid technology for other populations. Hearing care providers should continue to insist on research to support the choice of more costly premium technologies when prescribing hearing aids for older adults with presbycusis.Clinical Trial Registration:https://register.clinicaltrials.gov/, identifier NCT04539847.
Case report: Self-performed orthopedic exams in telehealth treatment of a youth athlete with acute rotator cuff strain
Authors: Wang Yuxuan , Yi Nuo , Ericksen Hayley M. , Zhang Wupeng 
Published: June 2023

BackgroundSports-related rotator cuff muscle injury is one of the most prevalent pathologies affecting overhead sports athletes. Since the COVID-19 pandemic and its subsequent stay-at-home protocols, physical therapy has transited into a new realm of telehealth. Current evidence regarding examining and managing RTC strain in telehealth physical therapy is minimal.Case presentationA self-referred 14-year-old female Chinese semi-professional tennis player presented with an acute right RTC strain. The mechanism of injury involved forehand strokes with left trunk rotation. No ligamentous or labral damage was observed on Magnetic Resonance Imagining. The individualized care plan included virtual partner-assisted assessment, online instructions on therapeutic exercises, and education with psychosocial considerations.Outcome and follow-upAfter a 6-week intervention, the patient demonstrated complete shoulder range of motion, full muscle strength, complete return-to-practice, 0% Quick DASH disability index, and 6/68 on the Tampa Scale for kinesiophobia.DiscussionThis case report demonstrated that telehealth is an accessible and cost-effective option for youth tennis athletes with RTC strain. This unique case showed a detailed roadmap from examination to discharge of this plan of care. There are also barriers including test and measure validity, and communication difficulties to be considered. Despite the challenges, this case was a good example of telehealth being an effective, repeatable, and cost-efficient option for patients with poor healthcare access.
A century of “Camel Research”: a bibliometric analysis
Authors: Kandeel Mahmoud , Morsy Mohamed A. , Abd El-Lateef Hany M. , Marzok Mohamed , El-Beltagi Hossam S. , Al Khodair Khalid M. , Soliman Wafaa E. , Albokhadaim Ibrahim , Venugopala Katharigatta N. 
Published: June 2023

IntroductionBibliometrics is a quantitative analytic strategy used to assess the unit of publications per each field of research. Bibliometric studies are commonly employed to examine the current research climate, potential developments, and development trends in certain domains. In this work, the major contributors to camel research throughout the past century are discussed, along with the funding sources, academic institutions, scientific disciplines, and countries that contributed to “Camel Research”.MethodsThe Web of Science (WOS) database was used to retrieve the publications based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) instructions.ResultsThere are 7,593 articles dedicated to camel research on the Web of Science (as of August 1st, 2022). Three stages were involved in the publication of a study on camels. At the beginning, from 1877 to 1965, there were fewer than ten new publications per year. The second stage comprised 100 publications per year (1968–2005). Since 2010, nearly 200 new papers have been published each year. King Saud and King Faisal universities contributed &gt; (0.08) of the total publications. While more than 1,000 funding agents were retrieved, the Natural Science Foundation of China (NSFC) showed the greatest rate of funded projects (0.17). Camel research was included in 238 scientific disciplines. The top disciplines were Veterinary Sciences (0.39), Agriculture Dairy Animal Science (0.144), and Food Science Technology (0.087).ConclusionThere has been an increase in interest in camels in recent years, but the research trends in camel health and production need greater support.
The local skin cellular immune response determines the clinical outcome of sarcoptic mange in Iberian ibex (Capra pyrenaica)
Authors: Valldeperes Marta , Granados José Enrique , Pérez Valentín , López-Olvera Jorge Ramón , Ráez-Bravo Arián , Fandos Paulino , Pérez Jesús M. , Mentaberre Gregorio , Tampach Stefania , Soriguer Ramón C. , Espinosa José 
Published: June 2023

IntroductionSarcoptic mange, caused by Sarcoptes scabiei, is a disease with implications for wildlife conservation and management. Its severity depends on the host’s local skin immune response, which is largely unknown in Iberian ibex (Capra pyrenaica), a mountain ungulate dramatically affected by mange. In this species, the clinical outcome of sarcoptic mange varies among individuals, and the local immune response could be key to controlling the infestation. This study aims to characterize the local cellular immune response and its relationship with the clinical outcome.MethodsFourteen Iberian ibexes were experimentally infested with S. scabiei and six more served as controls. Clinical signs were monitored, and skin biopsies were collected from the withers at 26, 46, and 103 days post-infection (dpi). The presence and distribution of macrophages (including M1 and M2 phenotypes), T lymphocytes, B lymphocytes, plasma cells, and interleukine 10 were quantitatively evaluated using immunohistochemical techniques.ResultsAn inflammatory infiltrate that decreased significantly from 26 to 103 dpi was observed in all the infested ibexes. The predominant inflammatory cell population in the skin of the mangy ibexes was formed by macrophages (mainly the M2 phenotype) followed by T lymphocytes, with lower numbers of B lymphocytes and plasma cells. Three clinical courses were identified: total recovery, partial recovery, and terminal stage. The inflammatory infiltrates were less pronounced in the fully recovered ibexes than in those that progressed to the terminal stage throughout the study.DiscussionThe results suggest an exacerbated but effective Th1-type cellular immune response controlling mange in Iberian ibex. Furthermore, the local immune response appears to determine the variability of the clinical responses to S. scabiei infestation in this species. This first report on the progression of local skin immune cells is relevant not only for individuals but also for population management and conservation.
Experimental and Numerical Study on the Ablation Analysis of a Pintle Injector for GOX/GCH4 Rocket Engines
Authors: Chang Yibing , Zou Jianjun 
Published: June 2023

In the present study, the ablation of a pintle injector on a 500N GOX/GCH4 rocket engine under different working conditions is studied experimentally and numerically. The temperature of the pintle tip and the combustion gas in the head zone was measured in a series of experiments by the thermocouples. Moreover, a three-dimensional model was established to simulate combustion and heat transfer concurrently and analyze the ablation state of the pintle injectors. The obtained results indicate that under a low chamber pressure (pc=0.25 MPa) and an increasing O/F ratio from 0.8 to 2, the tip temperature declines first, and then rises. At the designed working condition (pc=1.05 MPa and O/F = 3.2), the pintle tip suffered serious ablation, and the microstructure analysis indicates that the ablation failure of the stainless steel pintle tip originates from chromium precipitation. This phenomenon is especially more pronounced when the temperature exceeds 1273 K, which makes the structure fragile and vulnerable. This article helps to provide an understanding of the ablation failure of the pintle injectors, and the established model is capable of giving a prediction on the ablation status of the pintle tips consistent with the experiment.
Factorization of a Spectral Density with Smooth Eigenvalues of a Multidimensional Stationary Time Series
Authors: Szabados Tamás 
Published: June 2023

The aim of this paper to give a multidimensional version of the classical one-dimensional case of smooth spectral density. A spectral density with smooth eigenvalues and H∞ eigenvectors gives an explicit method to factorize the spectral density and compute the Wold representation of a weakly stationary time series. A formula, similar to the Kolmogorov–Szego” formula, is given for the covariance matrix of the innovations. These results are important to give the best linear predictions of the time series. The results are applicable when the rank of the process is smaller than the dimension of the process, which occurs frequently in many current applications, including econometrics.
Genome Analysis of a Variant of Streptomyces coelicolor M145 with High Lipid Content and Poor Ability to Synthetize Antibiotics
Authors: Dulermo Thierry , Lejeune Clara , Aybeke Ece , Abreu Sonia , Bleton Jean , David Michelle , Deniset-Besseau Ariane , Chaminade Pierre , Thibessard Annabelle , Leblond Pierre , Virolle Marie-Joelle 
Published: June 2023

Streptomyces coelicolor M145 is a model strain extensively studied to elucidate the regulation of antibiotic biosynthesis in Streptomyces species. This strain abundantly produces the blue polyketide antibiotic, actinorhodin (ACT), and has a low lipid content. In a process designed to delete the gene encoding the isocitrate lyase (sco0982) of the glyoxylate cycle, an unexpected variant of S. coelicolor was obtained besides bona fide sco0982 deletion mutants. This variant produces 7- to 15-fold less ACT and has a 3-fold higher triacylglycerol and phosphatidylethanolamine content than the original strain. The genome of this variant was sequenced and revealed that 704 genes were deleted (9% of total number of genes) through deletions of various sizes accompanied by the massive loss of mobile genetic elements. Some deletions include genes whose absence could be related to the high total lipid content of this variant such as those encoding enzymes of the TCA and glyoxylate cycles, enzymes involved in nitrogen assimilation as well as enzymes belonging to some polyketide and possibly trehalose biosynthetic pathways. The characteristics of this deleted variant of S. coelicolor are consistent with the existence of the previously reported negative correlation existing between lipid content and antibiotic production in Streptomyces species.
A Transformation Factor for Superluminal Motion That Preserves Symmetrically the Spacetime Intervals
Authors: Roldán Diego , Roldán-Aráuz Francisco 
Published: June 2023

While superluminal phenomena are not empirically substantiated, they present an intriguing hypothetical case. For this speculative framework, the Lorentz transformations would necessitate a revision: instead of the standard γ(x−vt), the absolute value of x′ ought to be expressed as γ(vt−x), because if v were to exceed c, then the interval vt traversed by the superluminal frame S′ would surpass the distance covered by light. Under the postulates of relativity, the subluminal scenario leads to the conventional Lorentz factor. Meanwhile, the superluminal scenario introduces an alternative transformation factor that accounts for the presence of the speed of light (c) barrier. This factor is also invariant within Minkowski spacetime, meaning it symmetrically preserves spacetime intervals. The details of this derivation become more evident when using a reverse coordinate system. This result is not, per se, evidence for the existence of superluminal phenomena, but it does allow us to speculate with a new argument about the possibility of their existence.
Gestão e tecnologia ambiental em postos de abastecimento de combustível
Authors: Da Conceição Mário Marcos Moreira , Mathews Josiane Coutinho , Borges Higor Ribeiro , E Silva Melissa Oliveira , Da Fonseca Danilo Puget , Batista Nubia Jane da Silva , Junior Wankes Solony de Carvalho Chaves , Guilherme Cláudio Roberto Araújo , Da Silva Ana Paula Silva , Da Silva Antonia Simone Farias , Freitas Seline Bruna dos Santos , Junior Natanael Silva Hungria , Freitas Zenaide Amaral , Machado Nathalia Ingrid Gomes , Da Silva Marília Palheta 
Published: June 2023

A proteção ao meio ambiente tem sido fator importante a ser observado na implantação e manutenção de empreendimentos. Inerente a periculosidade dos postos de combustíveis, a seção de revenda de derivados do petróleo apresenta potencial de poluição ou contaminação para o meio ambiente. O objetivo desta pesquisa foi avaliar o sistema de gestão ambiental de um posto de abastecimento localizado no município de Castanhal-PA, objeto desta pesquisa, e subsidiar a tomada de decisão dos empresários e do poder público. O método utilizado nesta pesquisa foi o dedutivo. A abrangência da pesquisa foi observativa, sistemática e direta, associada ao levantamento de dados documentais. O diagnóstico deu-se a partir de uma reflexão crítica e um trabalho de síntese, que permitiu a determinação da gestão ambiental do posto de abastecimento. Houve aplicação de formulário complementado de uma entrevista semiestruturada. Os dados obtidos indicaram que as águas residuais passam por ralos sifonados e caixas de gordura para decantação do material sólido que é coletado periodicamente através de uma empresa terceirizada especializada nesta atividade. O esgoto sanitário é tratado através de fossa séptica e os efluentes gerados a partir da lavagem de para-brisas e águas pluviais são recolhidos através de canaletas, que direcionam para a Caixa SAO (caixa Separadora de Água e Óleo). Os resíduos sólidos produzidos no empreendimento são comuns e não perigosos como papeis e plásticos. Estes resíduos serão organizados e recolhidos pelo serviço de limpeza urbana do município de Castanhal- PA. Foi possível identificar, que o posto adota medidas de gestão ambiental nos setores observados, como a conscientização na utilização de água, o recolhimento dos efluentes e resíduos provenientes do setor de lavagens e manutenções veiculares, a manutenção periódica da caixa separadora de água e óleo e treinamento especializado para os colaboradores, reduzindo significativamente os impactos ambientais.
A influencia da nutrição no envelhecimento cutaneo da mulher na menopausa
Authors: Brum Keron Ferreira , Spinelli Silvia Moro Conque 
Published: June 2023

A presente pesquisa teve por objetivo primário observar a influência da nutrição como determinante no processo do envelhecimento da pele, em um recorte de estudo com mulheres no período do climatério e menopausa, verificar a necessidade de suplementação ou dieta diferenciada para manter uma boa saúde da pele. Trata-se de revisão de literatura com estudo prospectivo por meio de enquetes em formulário eletrônico. Assim, o estudo apresenta alternativas que beneficiem os envolvidos, propiciando uma reflexão sobre as escolhas alimentares.
Interfência da analgesia no diagnóstico
Authors: Campos Sophia Maria Rocha , Pena Alice Campos , Fernandes Flávio Formiga , Batista Lorena Rodrigues , Duarte Alice Lima Dias , Barreiros Pâmela Gabrielle Lima , Panziera Letícia Gonçalves , Antunes Heloisa de Matos 
Published: June 2023

O uso de analgésicos em pacientes com dor abdominal aguda não diagnosticada é marcado por uma longa controvérsia sobre os efeitos da analgesia nos achados do exame físico. Analgésicos são frequentemente suspensos por medo de que possam mascarar os achados do exame físico e levar a atrasos ou falhas no diagnóstico. Dessa forma, o presente estudo visa discutir os achados e auxiliar na conduta médica na prática médica.