bluuebunny/crossref_metadata_2025_split huggingface dataset:
I'm Hopeless but I Still Have Hope
Authors: Gutkowski Stacey 
Published: August 2023

Abstract
Mannheim observed that generational memory is shaped by the prominent public events an age cohort experienced for the first time as young adults. For Jewish-Israeli millennials, born 1980–1995, their political coming of age was shaped by the failure of Oslo, cyclical violence, and Israel's pursuit of policies of population separation from Palestinians. This article draws on a wider, phenomenological study (2014–20) of post-Oslo generational memory of self-described hiloni (‘secular’ in Hebrew) millennials across the political spectrum from left to right. More richly theorizing and nuancing what is popularly assumed about this demographic, it argues that Oslo's legacy is hope-as-waiting behavior. It introduces Rengger's concept of the anti-Pelagian imaginary to discussions of attitudes to Occupation, making a case for more carefully specifying this sensibility by Jewish-Israeli demographic subgroup. To comparatively research hope amid intractable conflict calls for deeper analysis of hope-as-waiting as a category of action.
STRUCTURING OF LAND USE RESTRICTIONS IN UKRAINE
Authors: Petrakovska Olga , Mykhalova Mariia 
Published: August 2023

Establishing land use restrictions as a mechanism for ensuring favourable conditions for the life of the population and sustainable development of territories is of great importance. The study analysed the diversity of restrictions on land use, determined the grounds for setting land use restrictions, carried out their aggregation and structuring according to various characteristics, taking into account legal, spatial, social, economic and ecological aspects. During the research, methods of analysis and synthesis, comparison and system methods were used. Restrictions on land use are diversified in nature, size and grounds for establishment. The main basis for imposing restrictions on the land use in Ukraine is the necessity of natural resources preservation; ensuring the economic efficiency of territory development; ensuring social justice and protection of the population; environmental stability preservation territory restoration in the post-war period. The classification of land use restrictions is proposed depending on various classification features. The most significant among which are: presence of the mode-forming object as a basis for restriction; degree of determination; planning characteristics; validity term; ownerships of land in the area of limitations; access mode status for beneficiaries of specified benefits. The results of the study illustrate the need to further definition of the assessment of the impact of restrictions on social life.
ARCHITECTURAL AND PLANNING FEATURES OF COMPLEX CENTERS OF SOCIAL ASSISTANCE AND PSYCHOLOGICAL REHABILITATION ON THE EXAMPLE OF SUMY
Authors: Borodai Dmytro , Borodai Artem , Borodai Serhii 
Published: August 2023

The article is devoted to the study of the actual problem today. The problem of this article is the features of the architectural and planning organization of buildings of complex centers for social assistance and psychological rehabilitation. The article reviews the current research on this problem. The conditions for the optimal urban placement of these centers are determined. The definition of the object of study is formulated. The main functional processes typical for buildings of this purpose are determined. These are such functional processes: temporary accommodation, food, sanitary and hygienic services, medical care and rehabilitation, occupational therapy, cultural services, administrative services, security and safety. The main functional blocks of premises and their structural content are determined on the basis of these functions. The main functional units of the integrated center of social assistance and psychological rehabilitation are: administrative unit, professional rehabilitation unit, medical rehabilitation unit, social rehabilitation unit, legal services unit, aid to foreign citizen unit, social food and trade premises unit, cultural and entertainment premises unit, a block of premises for sports and rehabilitation purposes, a residential block for temporary stay.
Practical recommendations have been developed for the architectural and planning organization of the center for social assistance and psychological rehabilitation. A conceptual design of a complex center in Sumy has been designed. The city-planning, architectural-compositional and functional-planning solution of this complex center is proposed. The functional content of each functional block and the relationship between them are considered, taking into account regulatory requirements.
MATERNAL AND FETAL FACTORS ASSOCIATED WITH MISOPROSTOL USE IN MUBENDE REGIONAL REFERRAL HOSPITAL, UGANDA
Authors: OMONA Kizito , KOMAKETCH Denis 
Published: August 2023

There are numerous obstetric uses for misoprostol. It mimics the normal labour process by causing the uterus to contract strongly and by softening and dilating the cervix. This action makes it a uterotonic. The maternal uses include cervical ripening, initiating labour, treating incomplete abortions, preventing and treating postpartum haemorrhage, and causing abortions. This study sought to identify maternal and foetal risk factors related to misoprostol use among mothers who gave birth at the regional referral hospital in Mubende.
A mixed method analytical cross-sectional design was used with mothers, their infants, and healthcare professionals. 385 respondents made up the sample. Interviews, observation, and the review of documents were used to gather the data.
12.4% of mothers had ever used misoprostol. In comparison to mothers who lived in rural areas, urban mothers were two times more likely to have a positive history of misoprostol usage (COR=1.843, 95% CI (0.903-3.763)). Mothers with a parity of 2–4 had a 0.5x lower likelihood of using misoprostol [COR=0.514, 95% CI (0.166–1.595)]. Better APGAR scores of 4-7 (4 times) and 8-10 (2 times) in newborns were associated with a higher likelihood of a positive history of misoprostol use.
In conclusion, misoprostol use poses dangers to both the mother and the foetus, necessitating careful observance.
Broad-spectrum humanized monoclonal neutralizing antibody against SARS-CoV-2 variants, including the Omicron variant
Authors: Wen Kun , Cai Jian-Piao , Fan Xiaodi , Zhang Xiaojuan , Luo Cuiting , Tang Kai-Ming , Shuai Huiping , Chen Lin-Lei , Zhang Ricky Ruiqi , Situ Jianwen , Tsoi Hoi-Wah , Wang Kun , Chan Jasper Fuk-Woo , Yuan Shuofeng , Yuen Kwok-Yung , Zhou Hongwei , To Kelvin Kai-Wang 
Published: August 2023

IntroductionTherapeutic monoclonal antibodies (mAbs) against the SARS-CoV-2 spike protein have been shown to improve the outcome of severe COVID-19 patients in clinical trials. However, novel variants with spike protein mutations can render many currently available mAbs ineffective.MethodsWe produced mAbs by using hybridoma cells that generated from mice immunized with spike protein trimer and receptor binding domain (RBD). The panel of mAbs were screened for binding and neutralizing activity against different SARS-CoV-2 variants. The in vivo effectiveness of WKS13 was evaluated in a hamster model.ResultsOut of 960 clones, we identified 18 mAbs that could bind spike protein. Ten of the mAbs could attach to RBD, among which five had neutralizing activity against the ancestral strain and could block the binding between the spike protein and human ACE2. One of these mAbs, WKS13, had broad neutralizing activity against all Variants of Concern (VOCs), including the Omicron variant. Both murine or humanized versions of WKS13 could reduce the lung viral load in hamsters infected with the Delta variant.ConclusionsOur data showed that broad-spectrum high potency mAbs can be produced from immunized mice, which can be used in humans after humanization of the Fc region. Our method represents a versatile and rapid strategy for generating therapeutic mAbs for upcoming novel variants.
Acceptance of pay-as-you-throw solid waste charging methods among urban residents in China
Authors: Yao Wanjun , Zhou Xinyu 
Published: August 2023

Aim: Pay-as-you-throw (PAYT) is a recognized waste-charging method commonly used in developed countries to reduce waste effectively and improve resource utilization efficiency. China is currently transitioning from a traditional fixed-fee model to a PAYT model.Method: In this study, a sample of 1,346 urban residents in China is analyzed empirically to investigate their willingness to accept this change and the waste fees they are willing to pay for it.Results: The results indicate that, 1) at present, the proportion of urban residents willing to accept the PAYT charging model is low, accounting for only 54.53%. 2) The average annual cost for residents’ households willing to pay for PAYT is 58.616 RMB, which is relatively low. 3) The main reasons for the residents’ low acceptance of PAYT are behavioral attitudes, social norms, and perceived behavioral control factors. 4) Income and education levels mainly explain the low level of expenses paid by residents.Conclusion: Therefore, we suggest that, in the short term, publicity and education should be used to encourage residents to establish a correct environmental concept and a sense of environmental governance ownership, increase their knowledge of waste recycling and disposal and their awareness of waste charging rules, and thus improve their willingness to accept the PAYT charging model. In the long term, the PAYT charging model should be compatible with the levels of economic development and family education, and residents’ waste charges for PAYT should increase steadily.
Transport and accumulation of floating marine litter in the Black Sea: insights from numerical modeling
Authors: Castro-Rosero Leidy M. , Hernandez Ivan , Alsina José M. , Espino Manuel 
Published: August 2023

IntroductionFloating marine litter (FML) is a global problem with significant risks to marine life and human health. In semi-enclosed basins like the Black Sea, slow water replenishment and strong input from European rivers create conditions that can lead to the accumulation of FML. This study aims to validate and utilize an FML dispersion and accumulation numerical model. Additionally, it assesses the influence of Stokes drift on the accumulation patterns of marine litter in the Black Sea, focusing on the contribution from the main river discharge points.MethodsNumerical Lagrangian modeling adapted to the regional domain in the Black Sea was employed to simulate the dispersion and accumulation of FML. Three scenarios were conducted: two involved homogeneous particle release, one considering Stokes drift, and the other excluding it. The third scenario involved particle release from the nine main river basins.ResultsThe southwest coast of the Black Sea exhibited a high density of FML in all scenarios. This finding is likely attributed to the cyclonic circulation, significant FML input from the Danube River, and other northern rivers. Notably, the consideration of Stokes drift significantly impacted the residence time of particles in offshore waters and the percentage of particles washing up on the shore. Including Stokes drift increased the percentage of beached particles from 45.5% to 75.5% and reduced the average residence time from 99 to 63 days. These results align with recent literature, which emphasizes the importance of accounting for Stokes drift to avoid overestimating residence times.DiscussionThe model's findings provide valuable insights into FML accumulation patterns in the Black Sea. The eastern region near the Georgian coast and the northwestern Black Sea were identified as high-density areas, corroborated by observational data. This research underscores the significance of considering Stokes drift when modeling FML transport, particularly concerning marine litter accumulation and potential impacts on coastal regions.
Minor hallucinations in Parkinson’s disease with probable rapid eye movement sleep behavior disorder
Authors: Jiang Yinyin , Zhu Jun , Zhao Yang , Li Dongfeng , Chen Yaning , Wang Yaxi , Jiang Xu , Shen Bo , Pan Yang , Yan Jun , Han Feng , Zhang Li 
Published: August 2023

BackgroundRapid eye movement sleep behavior disorder (RBD) and minor hallucinations (MHs) are prevalent nonmotor symptoms in Parkinson’s disease (PD). The purpose of this study was to explore the association of MHs in PD patients with probable RBD (pRBD).MethodsThis cross-sectional study included 291 patients diagnosed with PD. Patients who scored 6 or higher on the Rapid Eye Movement Behavior Disorder (RBD) Screening Questionnaire were defined as pRBD. A comprehensive evaluation was performed for all patients, including the collection of demographic information, clinical assessment, and MH features.ResultsAmong the 291 PD patients, 69 (23.7%) had pRBD. MHs were observed in 35 (50.7%) patients with pRBD, significantly higher than 29.7% in patients without RBD (p = 0.015). The main type of MHs in pRBD was presence hallucinations with variable content. Patients with pRBD and MHs tended to be older, had a longer disease duration, and were more likely to take levodopa or dopamine-receptor agonists. Besides, the pRBD with MHs group had higher scores on the Nonmotor Symptoms Questionnaire (NMS-Quest) and Hamilton Anxiety Scale (HAMA). Binary logistic regression analysis revealed that longer disease duration and higher NMS-Quest scores were associated with MHs in PD patients with pRBD.ConclusionA high prevalence of MHs was observed in PD patients with pRBD. The main type of MHs in pRBD was presence hallucinations. MHs in PD with RBD are mainly associated with disease duration and severity of nonmotor symptoms. These findings provide new insights into the interaction between MHs and RBD.
Association between sulfur microbial diet and the risk of colorectal cancer precursors in older adults
Authors: Xiao Yi , He Hongmei , Xiang Ling , Gu Haitao , Xu Zhiquan , Luo Haoyun , Ren Xiaorui , Li Bo , Wei Qi , Zhu Zhiyong , Zhou He , Tang Yunhao , Zhou Zhihang , Peng Linglong , Wang Yaxu , Jiang Yahui 
Published: August 2023

BackgroundSulfur microbial diet (SMD), related to the enrichment of sulfur-metabolizing gut bacteria, has been confirmed to be linked to an elevated risk of early-onset colorectal adenoma in young females. However, it remains unclear whether SMD is associated with the risk of colorectal adenoma in older people, who are at greater risk for colorectal cancer.MethodsAll data on participants in this study were retrieved from the intervention arm of the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening test. Participants’ adherence to this dietary pattern was assessed using SMD score. Hazard ratios (HR) and 95% confidence intervals (CI) were adopted in Cox proportional hazards regression models to assess the link between SMD score and the incidence of colorectal adenoma in participants included in the study. Specific stratified analyses were constructed to assess whether this association changed in different conditions, whereas the robustness of the association was examined through sensitivity analyses.ResultsThe mean baseline age of participants was 62.1 (SD 5.2) years (range 54.0–75.0 years). During 19,468,589 person-years of follow-up, 992 colorectal adenoma cases were documented in a total of 17,627 included participants. In a fully adjusted model, an increased risk of colorectal adenoma was determined in participants in the highest quartile of SMD score in comparison with those in the lowest quartile (HRquartile4 vs. HRquartile1 = 1.23; 95% CI: 1.02, 1.47; p = 0.017 for trend). This positive association between SMD score and adenoma risk was more evident in participants who were current or former smokers (p = 0.029 for interaction).ConclusionIn this study, our results support a role for the SMD in the carcinogenicity of colorectal cancer precursors among older adults. Nevertheless, these results require validation through more research.
Nordic diet and its benefits in neurological function: a systematic review of observational and intervention studies
Authors: Jafari Reyhaneh Sadat , Behrouz Vahideh 
Published: August 2023

IntroductionNeurological disorders have been considered the major contributors to global long-term disability and lower quality of life. Lifestyle factors, such as dietary patterns, are increasingly recognized as important determinants of neurological function. Some dietary behaviors, such as Nordic diet (ND) were likely to have protective effects on brain function. However, an understanding of the effectiveness of the ND pattern to improve neurological function and brain health is not fully understood. We review the current evidence that supports the ND pattern in various aspects of neurological function and addresses both proven and less established mechanisms of action based on its food ingredients and biochemical compounds.MethodsIn this systematic review, PubMed, Web of Science, and Scopus databases were searched from inception to February 2023. Observational and intervention studies were included.ResultsOf the 627 screened studies, 5 observational studies (including three cohorts and two cross-sectional studies) and 3 intervention studies investigating the association between ND and neurological function. Observational studies investigated the association of ND with the following neurological functions: cognition, stroke, and neuropsychological function. Intervention studies investigated the effects of ND on cognition and depression.DiscussionDespite the limited literature on ND and its association with neurological function, several aspects of ND may lead to some health benefits suggesting neuroprotective effects. The current state of knowledge attributes the possible effects of characteristic components of the ND to its antioxidant, anti-inflammatory, lipid-lowering, gut-brain-axis modulating, and ligand activities in cell signaling pathways. Based on existing evidence, the ND may be considered a recommended dietary approach for the improvement of neurological function and brain health.Systematic review registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD2023451117].
Geriatric nutritional risk index was associated with in-hospital mortality among cardiac intensive care unit patients
Authors: Li Yuefeng , Wang Zhengdong , Sun Tienan , Zhang Biyang , Liang Xiangwen 
Published: August 2023

BackgroundIdentifying risk factors associated with cardiac intensive care unit (CICU) patients’ prognosis can help clinicians intervene earlier and thus improve their prognosis. The correlation between the geriatric nutrition risk index (GNRI), which reflects nutritional status, and in-hospital mortality among CICU patients has yet to be established.MethodThe present study retrospectively enrolled 4,698 CICU patients. Based on the nutritional status, the participants were categorized into four groups. The primary endpoint was in-hospital mortality. The length of hospital stay and length of CICU stay were the secondary endpoints. To explore the correlation between nutritional status and in-hospital mortality, a logistic regression analysis was conducted. The nonlinear associations of GNRI with in-hospital mortality were evaluated using restricted cubic spline (RCS). Furthermore, subgroup analyses were conducted to evaluate the effect of the GNRI on in-hospital mortality across different subgroups, with calculation of the p for interaction.ResultA higher risk of malnutrition was significantly linked to an increased incidence of in-hospital mortality (High risk vs. No risk: 26.2% vs. 4.6%, p &lt; 0.001), as well as a longer length of hospital stay (High risk vs. No risk: 15.7, 9.1–25.1 vs. 8.9, 6.9–12.9, p &lt; 0.001) and CICU stay (High risk vs. No risk: 6.4, 3.8–11.9 vs. 3.2, 2.3–5.1, p &lt; 0.001). An elevated GNRI was significantly associated with an increased risk of in-hospital mortality even after controlling for pertinent confounding factors (High risk vs. No risk: OR, 95% CI: 2.37, 1.67–3.37, p &lt; 0.001, p for trend &lt;0.001). Additionally, the RCS model showed a linear relationship between GNRI and in-hospital mortality, with the risk of in-hospital mortality significantly decreasing as GNRI increased (non-linear p = 0.596). Furthermore, in the subgroups of hypertension, ventricular arrhythmias, cardiac arrest, shock, and chronic kidney disease, there was a significant interaction between nutritional status and in-hospital mortality.ConclusionAmong CICU patients, a low GNRI was a significant predictor of in-hospital mortality. Furthermore, patients with a higher risk of malnutrition, as indicated by low GNRI values, experienced significantly longer hospital and CICU stays.
Cell cycle-specific phosphorylation of p53 protein in A549 cells exposed to cisplatin and standardized air pollutants
Authors: Niechoda Agata , Milewska Katarzyna , Roslan Joanna , Ejsmont Karolina , Holownia Adam 
Published: August 2023

Exposure to particulate matter is associated with DNA damage and the risk of lung cancer. Protein p53 is activated by multi-site phosphorylation in the early stages of DNA damage and affects cell outcome. Our study aimed to assess the effect of (100 µg/mL−1/24 h) standardized air pollutants: carbon black (CB), urban dust (UD), and nanoparticle carbon black (NPCB) on cell cycle, DNA damage and 53 phosphorylation at Ser 9, Ser 20, Ser 46, and Ser 392 in proliferating and quiescent A549 cells and in cells that survived cisplatin (CisPT) exposure. Phosphorylated p53 was quantified in cell subpopulations by flow cytometry using specific fluorochrome-tagged monoclonal antibodies and analysis of bivariate fluorescence distribution scatterplots. CisPT, UD and NPCB increased site-specific p53 phosphorylation producing unique patterns. NPCB activated all sites irrespectively on the cell cycle, while the UD was more selective. p53 Ser 9-P and p53 Ser 20-P positively correlated with the numbers of CisPT-treated cells at G0/G1, and NPCB and NPCB + CisPT produced a similar effect. A positive correlation and integrated response were also found between Ser 20-P and Ser 392-P in resting A549 cells treated with NPCB and CisPT but not UD. Interdependence between the expression of p53 phosphorylated at Ser 20, and Ser 392 and cell cycle arrest show that posttranslational alterations are related to functional activation. Our data suggest that p53 protein phosphorylation in response to specific DNA damage is driven by multiple independent and integrated pathways to produce functional activation critical in cancer prevention and treatment.