bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a core outcome set for pediatric chronic intestinal failure
Authors: Demirok Aysenur , Nagelkerke Sjoerd C. J. , Benninga Marc A. , Köglmeier Jutta , Mutanen Annika , Arnell Henrik , Felcht Judith , Guimber Dominique , Wahlstedt Christina , Avitzur Yaron , Lambe Cécile , Tabbers Merit M. ,   ERNICA Intestinal Failure Working Group and ESPGHAN Network of Intestinal Failure and Intestinal Transplant in Europe
Published: December 2022

AbstractBackgroundIn research on pediatric chronic intestinal failure, heterogeneity in reported definitions and outcomes exists. This leads to a risk of reporting bias and impossibility of evidence synthesis. Also, reported outcomes should be relevant to both healthcare providers and patients and their parents. Therefore, the aim of this study is to create a core outcome set (COS) to be used in studies on pediatric chronic intestinal failure.MethodsCandidate outcomes were selected from a recent systematic review. A three‐round Delphi study among key stakeholders and a consensus meeting with an expert panel were undertaken to achieve consensus on the COS.ResultsSeventy‐two stakeholders (79%) completed all three rounds of the Delphi process. Ninety‐eight outcomes were assessed, and five new outcomes were added after the first round. Ten outcomes were included in the final COS: weaning from parenteral nutrition, growth, mortality, central line–related infection, central line longevity, sepsis not related to central line infection, central line–related thrombosis, intestinal failure–associated liver disease, (serious) adverse events, and health‐related quality of life.ConclusionThis pediatric chronic intestinal failure COS consists of 10 outcomes important for all key stakeholders. Usage of this set in future research should minimize outcome heterogeneity and enhance the value of evidence synthesis. This will lead to better management in this field of rare gastrointestinal conditions.
Comparative analysis of sulfiredoxin and total oxidative stress levels in diabetic individuals with periodontitis: A case‐control study
Authors: TK Fayiza , Rao Ravi J. , S Srirangarajan , Prabhu Srikumar , Rudresh Vinaya , Oradiyath Deepika 
Published: December 2022

AbstractBackgroundThe delicate balance between oxidative stress and its antioxidant system can be disrupted in diabetes mellitus (DM), making the tissue susceptible to injury. Hence, this case‐control study aims to estimate and correlate the gingival tissue sulfiredoxin and crevicular total oxidative stress (TOS) levels in generalized periodontitis Stage II individuals Grade C (PSII) with and without type II DM.Material and MethodsA total of 72 individuals were grouped based on their glycosylated hemoglobin (HbA1c) levels and clinical parameters: group I, periodontally healthy non‐diabetic (HbA1c < 5.7%) (n = 24); group II, non‐diabetic with PSII (n = 24); and group III, diabetic individuals (HbA1c > 6.5%) with PSII (n = 24). Gingival tissues and crevicular fluid samples were collected. The samples with adequate protein concentrations (n = 72) were further estimated for sulfiredoxin and TOS levels by enzyme‐linked immunosorbent assay (ELISA) and calorimetric method, respectively.ResultsTissue sulfiredoxin and crevicular TOS levels are increased significantly in the periodontitis group compared to the non‐periodontitis group (p < 0.001).The tissue sulfiredoxin levels did not vary significantly between the two periodontitis groups (p < 0.179). The TOS levels are significantly higher in the diabetic compared to non‐diabetic periodontitis group (p < 0.001). Correlation statistics showed a significant positive correlation (r = 0.65 and p < 0.005) between sulfiredoxin and TOS levels in diabetes with PSII group, however, no such significant correlation was observed in the non‐diabetic PSII group (r = 0.255 and p < 0.422).ConclusionDiabetic individuals showed inadequate sulfiredoxin‐mediated antioxidant response to an increase in oxidative stress levels in periodontitis Stage II Grade C individuals.
Comparative analysis of proliferative and multilineage differentiation potential of human periodontal ligament stem cells from maxillary and mandibular molars
Authors: Mert Sinan , Malyaran Hanna , Craveiro Rogerio B. , Wolf Michael , Modabber Ali , Jahnen‐Dechent Willi , Neuss Sabine 
Published: December 2022

AbstractBackgroundClinical experience indicates that wounds in alveolar bone and periodontal tissue heal faster and more efficiently in the maxilla compared with the mandible. Since stem cells are known to have a decisive influence on wound healing and tissue regeneration, the aim of this study was to determine whether differences in proliferation and differentiation of periodontal ligament stem cells (PDLSC) from upper (u‐PDLSC) and lower jaw (l‐PDLSC) contribute to the enhanced wound healing in the maxilla.Methodsu‐PDLSC and l‐PDLSC from the same donor were harvested from the periodontal ligament of extracted human maxillary and mandibular third molars. Cell differentiation potential was assessed by analyzing stem cell markers, proliferation rate, and multilineage differentiation among each other and bone marrow‐derived mesenchymal stem cells (MSC). Successful differentiation of PDLSC and MSC toward osteoblasts, adipocytes, and chondrocytes was analyzed via reverse transcriptase‐quantitative polymerase chain reaction and histochemical staining (Alizarin Red, Oil Red O, Toluidine Blue).Resultsu‐PDLSC and l‐PDLSC expressed the MSC‐markers CD73+, CD90+, and CD105+ and lacked expression of CD34− and CD45−. Proliferation was significantly higher in u‐PDLSC than in l‐PDLSC, regardless of the culture conditions. Osteogenic (ALP, RunX2, and osteocalcin) and chondrogenic (SOX9 and ACAN) related gene expression as well as staining intensities were significantly higher in u‐PDLSC than in l‐PDLSC. No difference in adipogenic differentiation was observed.Conclusionu‐PDLSC showed a significantly higher proliferative and differentiation potential than l‐PDLSC, offering a possible cell‐based explanation for the differences in periodontal wound healing efficacy between maxilla and mandible.
The local crystallization thresholds under laser irradiation of the Cu+‐ion implanted Ge layers with various thicknesses
Authors: Pavlikov Alexander V. , Rogov Alexey M. , Sharafutdinova Alfia M. , Zoteyev Andrey V. , Khantimerov Sergey M. , Gavrilova Tatiana P. , Stepanov Andrey L. 
Published: December 2022

AbstractPorous Ge layers were fabricated by implanting Cu+ ions of various acceleration energies into c‐Ge substrate. This made it possible to form amorphous porous Ge layers of thicknesses from 18.6 to 50.5 nm. The distribution depth profiles of implanted Cu+ ions in Ge were simulated by SRIM‐2013 program. The formed layers were studied by Raman spectroscopy. The excitation was carried out by a laser with a wavelength of 488 nm, which has a small penetration depth of ∼20 nm. In the Raman spectra, there is a possibility to distinguish the contribution from the amorphous Ge film, the crystalline c‐Ge substrate, and Ge nanocrystals, which appear under intense laser excitation due to local crystallization. The decomposition of the spectra into individual components makes it possible to subtract the contribution of the substrate and estimate the crystalline volume fraction in the layers. The results obtained confirm the hypothesis of low thermal conductivity of the porous layer, due to which local crystallization occurs.
Aegilops sharonensis HMW‐GSs with unusually large molecular weight improves bread‐making quality in wheat‐Ae. sharonensis introgression lines
Authors: Li Yu , Li Qing , Hu Qian , Guzman Carlos , Lin Na , Xu Qiang , Zhang Yazhou , Lan Jingyu , Tang Huaping , Qi Pengfei , Deng Mei , Ma Jian , Wang Jirui , Chen Guoyue , Lan Xiujin , Wei Yuming , Zheng Youliang , Jiang Qiantao 
Published: December 2022

AbstractBackgroundEighteen wheat (Triticum aestivum‐Aegilops sharonensis) introgression lines were generated in the previous study. These lines possessed four types of high molecular weight glutenin subunit (HMW‐GS) combinations consisting of one glutenin from Ae. sharonensis (Glu‐1Ssh) plus one or more HMW‐GSs from common wheat (Glu‐A1, Glu‐B1, or Glu‐D1).ResultsIn this study, we conducted quality tests to explore the effects of 1Sshx2.3 and 1Sshy2.9 on the processing quality of 18 wheat‐Aegilops sharonensis introgression lines. Our data showed that the 1Sshx2.3 and 1Sshy2.9 subunits had a positive effect on gluten and baking quality. The bread volume of all these lines was higher than that of the parental wheat line LM3. In these lines, the HMW‐GS content and the HMW/LMW ratio of 66‐36‐11 were higher than those of LM3, and the 66‐36‐11 line exhibited greatly improved quality parameters in comparison with the parent LM3.ConclusionThese results demonstrated that the 1Sshx2.3 and 1Sshy2.9 subunits from Ae. sharonensis contributed immensely to gluten strength and bread‐baking quality, and proved a positive relationship between the HMW‐GS sizes and their effects on dough strength in vivo. The materials developed could be used by breeding programs aiming to increase bread‐making quality. © 2022 Society of Chemical Industry.
Telemedicine and psoriasis: A review based on statements of the telemedicine working group of the International Psoriasis Council
Authors: El Komy Mohamed H. M. , Chiricozzi Andrea , van de Kerkhof Peter , Armstrong April , Diamei Vahid , Hsu Christophe , Gelfand Joel , Navarini Alexander A. 
Published: December 2022

AbstractDuring the past few decades, classical in‐person communication has been enriched by opportunities for telemedicine. We are in a learning healthcare environment that takes advantage of the opportunities of telemedicine and in‐person consultations, reconciling the individuality of the patient and his/her psoriasis. A working group of experts in telemedicine was installed by the International Psoriasis Council (IPC) to formulate the opportunities and limitations of telemedicine in the diagnosis and treatment of psoriasis. The working group formulated statements on various aspects of telemedicine according to the nominal group technique to reach a consensus on these statements and explore the variation of opinions. Thirty‐six statements regarding teledermatology and psoriasis were agreed upon by the IPC working group. The value and necessity for the implementation of teledermatology in dermatologic healthcare practices for psoriasis are essential. Management of psoriasis through teledermatology is feasible with a few exceptions. In this communication, the statements are presented and discussed in the context of the available literature, and finally, a call to action by IPC is formulated related to these statements.
Effects of exclosures on woody species composition and carbon stocks: Lessons drawn from the Central Rift Valley, Ethiopia
Authors: Degefa Habtamu , Tolera Motuma , Kim Dong‐Gill , Mekuria Wolde 
Published: December 2022

AbstractEffects of exclosures on restoring degraded lands may vary with soil type, exclosure age, and conditions before the establishment of exclosures. Yet, studies investigating the effectiveness of exclosures in restoring degraded lands under different environmental conditions are lacking. This study aims at investigating the changes in woody species richness and diversity, and ecosystem carbon stocks after implementing exclosures in the Central Rift Valley, Ethiopia. Vegetation and soil data were gathered from 120 nested plots established in exclosures of eight and 30‐years‐old and adjacent grazing lands. Results showed that exclosures contained a higher number of economically important woody species compared to their respective adjacent grazing lands. However, the exclosures and respective adjacent grazing lands did not differ significantly in the diversity of tree and shrub species, and both the exclosures and adjacent grazing lands were dominated by few tree and shrub species. The older exclosure (30 years old) displayed significantly (p < 0.01) higher soil organic carbon and soil total nitrogen content and stocks than the adjacent grazing land, whereas the youngest exclosure (8 years old) did not show a significant difference in these variables. The results suggest that a longer time (e.g., ≥10 years) is needed to detect significant differences in soil organic carbon and total soil nitrogen. However, exclosures could bring considerable changes in woody species density in a relatively shorter period (e.g., ≤10 years) and support to restore degraded native woody species.
The combined profunda artery perforator‐gracilis flap for immediate facial reanimation and resurfacing of the radical parotidectomy defect
Authors: Yao Christopher M. K. , Jozaghi Yelda , Danker Sara , Karami Reem , Asaad Malke , Lai Stephen Y. , Hanna Ehab Y. , Esmaeli Bita , Gidley Paul W. , Chang Edward I. 
Published: December 2022

AbstractBackgroundA radical parotidectomy with facial nerve sacrifice results in facial nerve paralysis as well as a volume and often cutaneous defect. Prior experience with nerve grafting and static suspension has yielded suboptimal results. The present report aims to examine the feasibility and outcomes of a combined free gracilis and profunda artery perforator (PAP) flap from a single donor site can reconstruct these extensive defects and potentially restore dynamic facial reanimation even in the setting of adjuvant radiation.Patients and MethodsA retrospective review of 10 patients (6 males and 4 females) was performed from 2016 to 2020 that underwent a combined PAP‐gracilis reconstruction of a radical parotidectomy defect. All patients (mean age: 71.3 years; range: 52–83 years) received adjuvant radiation. A chimeric PAP‐gracilis flap requiring a single microvascular anastomosis was performed in three patients while the remaining patients underwent a double free flap reconstruction.ResultsThe gracilis flap was innervated using the facial nerve stump, spinal accessory and massecteric nerve in three patients each. One patient's gracilis was innervated using the hypoglossal nerve. Three patients also underwent nerve grafting of the facial nerve. One patient was taken back to the operating room for a hematoma in the recipient site and there were not flap losses of either the PAP or gracilis flap. Two patients had delayed wound healing of the donor site that healed with conservative management. Average follow‐up was 11.1 months (range: 8.1–19.5 months). Six patients were able to achieve dynamic animation while the others obtained a static reconstruction and did not have issues with drooling, eating, or speaking.ConclusionsImmediate functional muscle transfer can potentially restore dynamic facial reanimation even following radiation. Combining reconstruction using a PAP‐gracilis flap addresses the soft tissue deficit and facial paralysis using a single donor site in a single operation.
Total‐body low‐dose CT image denoising using a prior knowledge transfer technique with a contrastive regularization mechanism
Authors: Fu Minghan , Duan Yanhua , Cheng Zhaoping , Qin Wenjian , Wang Ying , Liang Dong , Hu Zhanli 
Published: December 2022

AbstractPurposeReducing the radiation exposure experienced by patients in total‐body computed tomography (CT) imaging has attracted extensive attention in the medical imaging community. A low radiation dose may result in increased noise and artifacts that greatly affect the subsequent clinical diagnosis. To obtain high‐quality total‐body low‐dose CT (LDCT) images, previous deep learning‐based research works developed various network architectures. However, most of these methods only employ normal‐dose CT (NDCT) images as ground truths to guide the training process of the constructed denoising network. As a result of this simple restriction, the reconstructed images tend to lose favorable image details and easily generate oversmoothed textures. This study explores how to better utilize the information contained in the feature spaces of NDCT images to guide the LDCT image reconstruction process and achieve high‐quality results.MethodsWe propose a novel intratask knowledge transfer (KT) method that leverages the knowledge distilled from NDCT images as an auxiliary component of the LDCT image reconstruction process. Our proposed architecture is named the teacher–student consistency network (TSC‐Net), which consists of teacher and student networks with identical architectures. By employing the designed KT loss, the student network is encouraged to emulate the teacher network in the representation space and gain robust prior content. In addition, to further exploit the information contained in CT scans, a contrastive regularization mechanism (CRM) built upon contrastive learning is introduced. The CRM aims to minimize and maximize the L2 distances from the predicted CT images to the NDCT samples and to the LDCT samples in the latent space, respectively. Moreover, based on attention and the deformable convolution approach, we design a dynamic enhancement module (DEM) to improve the network capability to transform input information flows.ResultsBy conducting ablation studies, we prove the effectiveness of the proposed KT loss, CRM, and DEM. Extensive experimental results demonstrate that the TSC‐Net outperforms the state‐of‐the‐art methods in both quantitative and qualitative evaluations. Additionally, the excellent results obtained for clinical readings also prove that our proposed method can reconstruct high‐quality CT images for clinical applications.ConclusionsBased on the experimental results and clinical readings, the TSC‐Net has better performance than other approaches. In our future work, we may explore the reconstruction of LDCT images by fusing the positron emission tomography (PET) and CT modalities to further improve the visual quality of the reconstructed CT images.
Clinical ultra‐high resolution CT scans enabled by using a generative adversarial network
Authors: Sun Yao , Pan Boyang , Li Qingchu , Wang JiaChen , Wang Xiang , Chen Honghua , Cao Qing , Liu Hui , Feng Tao , Sun Hongbiao , Xiao Yi , Gong Nan‐Jie 
Published: December 2022

AbstractBackgroundUltra‐high resolution computed tomography (UHRCT) has shown great potential for the detection of pulmonary diseases. However, UHRCT scanning generally induces increases in scanning time and radiation exposure. Super resolution is a gradually prosperous application in CT imaging despite higher radiation dose. Recent works have proved that the convolution neural network especially the generative adversarial network (GAN) based model could generate high‐resolution CT using phantom images or simulated low resolution data without extra dose. Research that used clinical CT particularly lung images are rare due to the difficulty in collecting paired dataset.PurposeTo generate clinical UHRCT in lung from low resolution computed tomography (LRCT) using a GAN model.Methods43 clinical scans with LRCT and UHRCT were collected in this study. Paired patches were selected using the structural similarity index measure (SSIM) and the peak signal‐to‐noise ratio (PSNR) threshold. A relativistic GAN with gradient guidance was trained to learn the mapping from LRCT to UHRCT. The performance of the proposed method was evaluated using PSNR and SSIM. A reader study with five‐point Likert score (five for the worst and one for the best) is also applied to assess the proposed method in terms of general quality, diagnostic confidence, sharpness and denoise level.ResultsExperimental results show that our method got PSNR 32.60 ± 2.92 and SSIM 0.881 ± 0.057 on our clinical CT dataset, outperforming other state‐of‐the‐art methods based on the simulated scenarios. Moreover, reader study shows that our method reached the good clinical performance in terms of general quality (1.14 ± 0.36), diagnostic confidence (1.36 ± 0.49), sharpness (1.07 ± 0.27) and high denoise level (1.29 ± 0.61) compared to other SR methods.ConclusionThis study demonstrated the feasibility of generating UHRCT images from LRCT without longer scanning time or increased radiation dose.
Exploring the potential of the novel imidazole‐4,5‐dicarboxyamide chemical exchange saturation transfer scaffold for pH and perfusion imaging
Authors: Bo Shaowei , Stabinska Julia , Wu Yunkou , Pavuluri Kowsalya Devi , Singh Aruna , Mohanta Zinia , Choudhry Rehan , Kates Max , Sedaghat Farzad , Bhujwalla Zaver , Pomper Martin G. , McMahon Michael T. 
Published: December 2022

AbstractHere, we describe and assess the potential of 14 newly synthesized imidazole‐4,5‐dicarboxyamides (I45DCs) for pH and perfusion imaging. A number of these aromatic compounds possess large labile proton chemical shifts (up to 7.7 ppm from water) because of their intramolecular hydrogen bonds and a second labile proton to allow for chemical exchange saturation transfer (CEST) signal ratio‐based pH measurements. We have found that the contrast produced is strong for a wide range of substitutions and that the inflection points in the CEST signal ratio versus pH plots used to generate concentration‐independent pH maps can be adjusted based on these subsitutions to tune the pH range that can be measured. These I45DC CEST agents have advantages over the triiodobenzenes currently employed for tumor and kidney pH mapping, both preclinically and in initial human studies. Finally, as CEST MRI combined with exogenous contrast has the potential to detect functional changes in the kidneys, we evaluated our highest performing anionic compound (I45DC‐diGlu) on a unilateral urinary obstruction mouse model and observed lower contrast uptake in the obstructed kidney compared with the unobstructed kidney and that the unobstructed kidney displayed a pH of ~ 6.5 while the obstructed kidney had elevated pH and an increased range in pH values. Based on this, we conclude that the I45DCs have excellent imaging properties and hold promise for a variety of medical imaging applications, particularly renal imaging.
Nursing care provided at medical institutions to female victims immediately after a sexual assault incident: A qualitative descriptive study
Authors: Fukumoto Tamaki 
Published: December 2022

AbstractAimTo clarify the content of nursing care provided to sexually assaulted females when they present at a medical institution immediately after the assault.DesignQualitative descriptive study.MethodsIndividual semi‐structured interviews were conducted with 20 female nurses and midwives affiliated with medical institutions collaborating with the one‐stop Support Center for sexual violence victims. Data were analysed using content analysis.ResultsThe study identified five forms of nursing care: providing safety and reassurance, supporting smooth physical exams, building trusting relationships, supporting the recovery of emotional/physical health and dignity, and ensuring continuity of support. There were three types of institutional systems in victim care: (a) male doctors are sometimes involved in care, (b) female doctors provide care with nursing supervisors, and (c) female doctors take the lead to provide care. Nursing care content extracted in this study was influenced by the structure of the medical institution with which the nurses were affiliated.