bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual lumen cannulation and mobilization of patients with venovenous extracorporeal membrane oxygenation
Authors: Noe Christian , Rottmann Felix A. , Bemtgen Xavier , Supady Alexander , Wengenmayer Tobias , Staudacher Dawid L. 
Published: June 2023

AbstractBackgroundMobilization is important in longer courses in intensive care unit (ICU), typical for patients requiring venovenous extracorporeal membrane oxygenation (V‐V ECMO). For patients supported with ECMO, especially out‐of‐bed mobilizations improve outcome. We hypothesized that utilization of a dual lumen cannula (DLC) for V‐V ECMO would facilitate out‐of‐bed mobilization compared to single lumen cannulas (SLC).MethodsRetrospective single center registry study including all V‐V ECMO patients cannulated between 10/2010 and 05/2021 for respiratory failure.ResultsThe registry included 355 V‐V ECMO patients (median age 55.6 years, 31.8% female, 27.3% with preexisting pulmonary disease), 289/355 (81.4%) primary cannulated with DLC, and 66/355 (18.6%) using SLC. Both groups had similar pre‐ECMO characteristics. The runtime of the first ECMO cannula was significantly longer in DLC compared to SLC (169 vs. 115 h, p = 0.015). The frequency of prone positioning during V‐V ECMO was similar in both groups (38.4 vs. 34.8%, p = 0.673). There was no difference in in‐bed mobilization (41.2 vs. 36.4%, for DLC and SLC, respectively, p = 0.491). Patients with DLC were more often mobilized out‐of‐bed (25.6 vs. 12.1%, OR 2.495 [95% CI 1.150 to 5.268], for DLC and SLC, respectively, p = 0.023). Hospital survival was similar in both groups (46.4 vs. 39.4%, for DLC and SLC, respectively, p = 0.339).ConclusionPatients cannulated with a dual lumen cannula for V‐V ECMO support were significantly more often mobilized out‐of‐bed. Since mobilization is important in prolonged ICU courses typical for ECMO patients, this might be an important benefit. Other benefits of DLC were the longer runtime of the initial cannula set and fewer suction events.
Creating organizational value and sustainability through green HR practices: An innovative approach with the moderating role of top management support
Authors: Chatterjee Sheshadri , Chaudhuri Ranjan , Vrontis Demetris 
Published: June 2023

AbstractGreen human resource management (GHRM) seeks to reorient human resource strategy and practices to an organization's environmental sustainability goals. A small body of research has so far shown that GHRM is positively related to organizational sustainability, yet the results are somewhat variable. This calls into question regarding the boundary conditions of this relationship. In this study, the moderating role of top management team (TMT) support has been examined as senior managers have a key role to play in ensuring that GHRM is valued, widely recognized, and implemented as intended. Based on the existing literature, a model has been developed and then tested with partial least square structural equation modeling, with feedback from 372 human resource managers across several organizations. The results show a positive relationship between GHRM and sustainability, and the results also show that the TMT support strengthens this relationship. Importantly, the study reveals a positive and significant relationship between sustainability and organizational performance.
Sample Size and Power Determination for Multiparameter Evaluation in Nonlinear Regression Models with Potential Stratification
Authors: Martens Michael J. , Kim Soyoung , Ahn Kwang Woo 
Published: June 2023

Abstract
Sample size and power determination are crucial design considerations for biomedical studies intending to formally test the effects of key variables on an outcome. Other known prognostic factors may exist, necessitating the use of techniques for covariate adjustment when conducting this evaluation. Moreover, the main interest often includes assessing the impact of more than one variable on an outcome, such as multiple treatments or risk factors. Regression models are frequently employed for these purposes, formalizing this assessment as a test of multiple regression parameters. But, the presence of multiple variables of primary interest and correlation between covariates can complicate sample size/power calculation. Given the paucity of available sample size formulas for this context, these calculations are often performed via simulation, which can be both time-consuming as well as demanding extensive probability modeling. We propose a simpler, general approach to sample size and power determination that may be applied when testing multiple parameters in commonly used regression models, including generalized linear models as well as ordinary and stratified versions of the Cox and Fine–Gray models. Through both rigorous simulations and theoretical derivations, we demonstrate the formulas' accuracy in producing sample sizes that will meet the type I error rate and power specifications of the study design.
The architectonic of Foucault's critique
Authors: Lorenzini Daniele , Tiisala Tuomo 
Published: June 2023

AbstractThis paper presents a new interpretation of Michel Foucault's critical project. It is well known that Foucault's genealogical critique does not focus on issues of justification, but instead tackles “aspectival captivity,” that is, apparently inevitable limits of thought that constrain the subject's freedom but that, in fact, can be transformed. However, it has not been recognized that, according to Foucault, critique can proceed along two distinct paths. In a key passage of “What Is Critique?,” Foucault states that critique is tasked with questioning truth about its effects of power and with questioning power about its discourses of truth. We show that this “double movement” organizes Foucault's critical project as a whole, giving it a significantly wider scope and a more complex structure than has been previously acknowledged. At the heart of the above‐mentioned bifurcation lies an apparent tension between two contrastive roles Foucault assigns to truth‐telling in the context of critique: on the one hand, truth‐telling (as avowal) is a target of critique; on the other, truth‐telling (as parrhesia) is one of critique's methods. We argue that combining these two dimensions in a unified account is crucial for understanding and re‐evaluating Foucault's critical project as a whole. By showing that truth‐telling remains an essential element of Foucauldian critique, this paper also rectifies some influential misinterpretations according to which Foucault's critical project seeks to eliminate truth from the picture.
Food fraud detection using explainable artificial intelligence
Authors: Buyuktepe Okan , Catal Cagatay , Kar Gorkem , Bouzembrak Yamine , Marvin Hans , Gavai Anand 
Published: June 2023

AbstractRecently, the global food supply chain has become increasingly complex, and its scalability has grown. From farm to fork, the performance of food‐producing systems is influenced by significant changes in the environment, population and economy. These changes may cause an increase in food fraud and safety hazards and hence, harm human health. Adopting artificial intelligence (AI) technology in the food supply chain is one strategy to reduce these hazards. Although the use of AI has been rising in numerous industries, such as precision nutrition, self‐driving cars, precision agriculture, precision medicine and food safety, much of what AI systems do is a black box due to its poor explainability. This study covers numerous use cases of food fraud risk prediction using explainable artificial intelligence (XAI) techniques, such as LIME, SHAP and WIT. We aimed to interpret the predictions of a machine learning model with the aid of these technologies. The case study was performed on a food fraud dataset using adulteration/fraud notifications retrieved from the Rapid Alert System for Food and Feed system and economically motivated adulteration database. A deep learning model was built based on this dataset and XAI tools have been investigated on the proposed deep learning model. Both features and shortcomings of the current XAI tools in the food fraud area have been presented.
Visual hypersensitivity in patients treated with anti‐calcitonin gene–related peptide (receptor) monoclonal antibodies
Authors: de Vries Lentsch Simone , Perenboom Matthijs J. L. , Carpay Johannes A. , MaassenVanDenBrink Antoinette , Terwindt Gisela M. 
Published: June 2023

AbstractObjectiveTo evaluate the effect of treatment with anti‐calcitonin gene–related peptide (CGRP; receptor) antibodies on visual hypersensitivity in patients with migraine.BackgroundIncreased visual sensitivity can be present both during and outside migraine attacks. CGRP has been demonstrated to play a key role in light‐aversive behavior.MethodsIn this prospective follow‐up study, patients treated for migraine with erenumab (n = 105) or fremanezumab (n = 100) in the Leiden Headache Center were invited to complete a questionnaire on visual sensitivity (the Leiden Visual Sensitivity Scale [L‐VISS]), pertaining to both their ictal and interictal state, before starting treatment (T0) and 3 months after treatment initiation (T1). Using a daily e‐diary, treatment effectiveness was assessed in weeks 9–12 compared to a 4‐week pre‐treatment baseline period. L‐VISS scores were compared between T0 and T1. Subsequently, the association between the reduction in L‐VISS scores and the reduction in monthly migraine days (MMD) was investigated.ResultsAt 3 months, the visual hypersensitivity decreased, with a decrease in mean ± standard deviation (SD) ictal L‐VISS (from 20.1 ± 7.7 to 19.2 ± 8.1, p = 0.042) and a decrease in mean ± SD interictal L‐VISS (from 11.8 ± 6.6 to 11.1 ± 7.0, p = 0.050). We found a positive association between the reduction in MMD and the decrease in interictal L‐VISS (β = 0.2, p = 0.010) and the reduction in ictal L‐VISS (β = 0.3, p = 0.001).ConclusionA decrease in visual hypersensitivity in patients with migraine after treatment with anti‐CGRP (receptor) antibodies is positively associated with clinical response on migraine.
Domesticated Australian wattle seeds (Acacia species): nutritional values, techno‐functional properties and toxicological assessments after roasting
Authors: Adiamo Oladipupo Q. , Phan Anh Dao Thi , Akter Saleha , Sivakumar Dharini , Seke Faith , Cunningham Peter , Sultanbawa Yasmina 
Published: June 2023

SummaryThis study evaluated the nutritional composition, anti‐nutritional factors, djenkolic acid (DKA) contents and techno‐functional properties of commercial raw, light and medium roasted wattle seed (WS) flour from 10 domesticated Australian Acacia species. The results showed that the species are a good source of dietary fibre, protein, fat and minerals (K, Ca, Mg, P and Fe). Moreover, the species have substantial amounts of linolenic acid and essential amino acids (EAAs), except for methionine and phenylalanine, indicating the high fat and protein quality of the species. Low‐trypsin inhibitor activity (TIA) and DKA contents were found in the species, except for the high TIA in A. longifolia spp. sophorae (18.3 mg TUI/g), A. longifolia spp. longifolia (12.3 mg TUI/g) and A. provincialis (12.2 mg TUI/g). In contrast, light and medium roasting effectively reduced the TIA and DKA levels as well as foaming and emulsifying properties. The greatest reduction in these properties was noticed in medium‐roasted samples. However, roasting appears to retain most of the nutritive value in the species and, the species exhibited high‐water absorption capacity, making them suitable for use as ingredients in bakery applications.
Effects of different preservation schemes on isolated rat artery
Authors: Ren Zhang‐Yong , Wu Qiao , Pan Bing , Liu Jia‐Zong , He Qiang , Lang Ren , Lyu Shao‐Cheng 
Published: June 2023

AbstractAllogeneic blood vessels are regarded as one of the best natural substitutes for diseased blood vessels due to their good vascular compliance and histocompatibility. Since the supply and demand of allograft blood vessels do not always match in time and space, a good preservation scheme for isolated blood vessels is essential. The abdominal aortas of 110 male Sprague–Dawley (SD) rats were randomly divided into three groups, including cold storage group (4°C) (CSG), frozen storage group (FSG) and ambient storage group (25 ± 2°C) (ASG). Seven time points of preservation for 1, 3, 5, 7, 14, 30 and 90 days were set for detection. The changes in vascular physiological function were evaluated by MTT test and vasoconstriction ability detection, and the changes in vascular wall structure were evaluated by the tension tolerance test and pathological staining. The vascular function of CSG was better than FSG within first the 7 days, but the result was opposite since the 14th day. The vascular wall structure, collagen and elastic fibres of vessels, in CSG, showed oedema within 30 days, and continuous disintegration and rupture at 90 days. The vessel wall structure of FSG remained intact within 90 days. The tensile strength of the vessels in CSG was better than that in FSG within 5 days, and there was no statistical difference between the two groups between the 7th and 30th day, and then, the FSG was higher than CSG on the 90th day. Both cold storage and frozen storage could be applied as safe and effective preservation schemes for isolated rat artery within first 30 days. Cold storage is recommended when the storage time is <14 days, and then, frozen storage is better.
Price promotions as a threat to brands
Authors: Inderst Roman , Obradovits Martin 
Published: June 2023

AbstractManufacturers frequently resist heavy discounting of their products by retailers. Since low prices should increase demand and manufacturers could simply refuse to fund deep price promotions, such resistance is puzzling at first sight. We develop a model in which price promotions cause shoppers to evaluate the relative importance of quality and price against a market‐wide reference point. With deep discounting, consumers perceive quality differences as less pronounced, eroding brand value and the bargaining position of brand manufacturers. This reduces their profits and may even lead to a delisting of their products. By linking price promotions to increased one‐stop shopping and more intense retail competition, our theory also offers an explanation for the rise of store brands.
The experience of pain and its ontological modelling from a philosophical point of view: Phenomenological description and ontological revision of the McGill Pain Questionnaire
Authors: Lanfredini Roberta , Cipriani Letizia 
Published: June 2023

AbstractThe aim of the article is to identify, on the basis of the phenomenological and ontological analysis of the experience of pain and the ways in which this experience is expressed in natural language, an ontological modelling of the language of pain and, at the same time, a revision of the traditional version of the McGill questionnaire. The purpose is to provide a different characterisation and an adequate evaluation of the phenomenon of pain, and, consequently, an effective measure of the actual experience of the suffering subject.
Major histocompatibility complex class IIα and IIβ of pufferfish (Takifugu obscurus): Identification and functional characterization in response to bacterial challenge
Authors: Qian Kun , Fu Shengli , Wang Junru , Li Yuan , Xian Jianan , Ye Jianmin 
Published: June 2023

AbstractClassical major histocompatibility complex (MHC) class II molecules play an essential role in immune system. In this study, MHC IIα (Pf‐MHC IIα) and MHC IIβ (Pf‐MHC IIβ) homology genes from pufferfish (Takifugu obscurus) were cloned and their functional characterization in response to bacterial challenge was identified. The nucleotide sequences of the open reading frames (ORFs) of pufferfish Pf‐MHC IIα and Pf‐MHC IIβ were 708 bp and 750 bp, encoding 235 aa and 249 aa, respectively. The structure of Pf‐MHC IIα or Pf‐MHC IIβ contained a signal peptide, an α1/β1 domain, an α2/β2 domain, a transmembrane region and a cytoplasmic region. Multiple sequence alignment and phylogenetic analysis showed that Pf‐MHC IIα and Pf‐MHC IIβ molecules had the highest similarity with Fugu rubripes (Takifugu rubripes). Cellular localization analysis indicated that the distribution of Pf‐MHC IIα and Pf‐MHC IIβ was in the lymphocyte membrane and cytoplasm. qRT‐PCR results showed that Pf‐MHC IIα and Pf‐MHC IIβ expressed relatively high in skin, gills and gut. In addition, after stimulation challenge in vitro (lipopolysaccharide, or polyinosinic: polycytidylic acid) and in vivo (A. hydrophila), the mRNA expressions of Pf‐MHC IIα and Pf‐MHC IIβ were significantly up‐regulated in lymphocytes and in tissues of skin, gills, gut and head kidney. Moreover, Pf‐MHC IIα or Pf‐MHC IIβ neutralization reduced the ability of A. hydrophila to induce the expressions of lymphocyte cytokines (TNF‐α, IL‐1β and IL‐10). Overall, it is speculated that Pf‐MHC IIα and Pf‐MHC IIβ may play an important role in the host response against A. hydrophila in pufferfish.
Development and evaluation of an intelligentUVCsterilization system for raw aquatic food production
Authors: Li You , Liu Feng , Xing Shaohua , Wang Xiang , Liu Xingxing 
Published: June 2023

AbstractRaw aquatic food is regarded as an important source of proteins. However, the presence of various bacteria can increase the risk of disease in humans. As a result, a crucial step in the processing of aquatic products is the disinfection of raw aquatic food. An intelligent ultraviolet c radiation (UVC) sterilization system was established and evaluated in this study. On the automated production line, the UVC lamp's sterilization intensity can be automatically adjusted to achieve intelligent sterilization of the various aquatic product categories. The system was implemented and evaluated for oyster surface sterilization experiments in the production line. The quality indicators of oysters, such as volatile salt nitrogen content and aerobic bacterial count, were measured before and after sterilization. The average sterilization rate of the intelligent system is 96.4%. The results showed that the system had an excellent sterilization effect and improved the shelf life of aquatic products.
Identifying Medicare beneficiaries with Alzheimer's disease and related dementia using home healthOASISassessments
Authors: Bélanger Emmanuelle , Rosendaal Nicole , Gutman Roee , Lake Derek , Santostefano Christopher M. , Meyers David J. , Gozalo Pedro L. 
Published: June 2023

AbstractBackgroundHome health services are an important site of care following hospitalization among Medicare beneficiaries, providing health assessments that can be leveraged to detect diagnoses that are not available in other data sources. In this work, we aimed to develop a parsimonious and accurate algorithm using home health outcome and assessment information set (OASIS) measures to identify Medicare beneficiaries with a diagnosis of Alzheimer's disease and related dementia (ADRD).MethodsWe conducted a retrospective cohort study of Medicare beneficiaries with a complete OASIS start of care assessment in 2014, 2016, 2018, or 2019 to determine how well the items from various versions could identify those with an ADRD diagnosis by the assessment date. The prediction model was developed iteratively, comparing the performance of different models in terms of sensitivity, specificity, and accuracy of prediction, from a multivariable logistic regression model using clinically relevant variables, to regression models with all available variables and predictive modeling techniques, to estimate the best performing parsimonious model.ResultsThe most important predictors of having a diagnosis of ADRD by the start of care OASIS assessment were a prior discharge diagnosis of ADRD among those admitted from an inpatient setting, and frequently exhibiting symptoms of confusion. Results from the parsimonious model were consistent across the four annual cohorts and OASIS versions with high specificity (above 96%), but poor sensitivity (below 58%). The positive predictive value was high, over 87% across study years.ConclusionsThe proposed algorithm has high accuracy, requires a single OASIS assessment, is easy to implement without sophisticated statistical models, and can be used across four OASIS versions and in situations where claims are not available to identify individuals with a diagnosis of ADRD, including the growing population of Medicare Advantage beneficiaries.
Circadian rhythm alterations affecting the pathology of neurodegenerative diseases
Authors: Canever Jaquelini Betta , Queiroz Letícia Yoshitome , Soares Ericks Sousa , de Avelar Núbia Carelli Pereira , Cimarosti Helena Iturvides 
Published: June 2023

AbstractThe circadian rhythm is a nearly 24‐h oscillation found in various physiological processes in the human brain and body that is regulated by environmental and genetic factors. It is responsible for maintaining body homeostasis and it is critical for essential functions, such as metabolic regulation and memory consolidation. Dysregulation in the circadian rhythm can negatively impact human health, resulting in cardiovascular and metabolic diseases, psychiatric disorders, and premature death. Emerging evidence points to a relationship between the dysregulation circadian rhythm and neurodegenerative diseases, suggesting that the alterations in circadian function might play crucial roles in the pathogenesis and progression of neurodegenerative diseases. Better understanding this association is of paramount importance to expand the knowledge on the pathophysiology of neurodegenerative diseases, as well as, to provide potential targets for the development of new interventions based on the dysregulation of circadian rhythm. Here we review the latest findings on dysregulation of circadian rhythm alterations in Parkinson's disease, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, spinocerebellar ataxia and multiple‐system atrophy, focusing on research published in the last 3 years.image
Does BRAF V600E mutation affect recurrence rate of ameloblastomas? Systematic review and meta‐analysis
Authors: Martins‐de‐Barros Allan Vinícius , Silva Caio César Gonçalves , Gonçalves Kalyne Kelly Negromonte , de Albuquerque Cavalcanti Almeida Renata , de Oliveira e Silva Emanuel Dias , da Costa Araújo Fábio Andrey , Robinson Liam , van Heerden Willie F. P. , de Vasconcelos Carvalho Marianne 
Published: June 2023

AbstractObjectiveThe objective of this systematic review with meta‐analysis was to critically evaluate the available data on the association of the BRAF V600E mutation and recurrence rate of ameloblastomas.Materials and MethodsThis systematic review was registered in Prospero (CRD42020183645) and performed based on the PRISMA statement. A comprehensive search in PubMed, Web of Science, Scopus and Cochrane Library databases was performed in order to answer the question “Does BRAF V600E mutation affect recurrence rate of ameloblastomas?” Methodological quality and risk of bias of the selected studies were assessed with JBI Critical Appraise Tool. Meta‐analysis of quantitative data was conducted with RevMan 5.3 and Jamovi 2.3.ResultsThe initial search identified 302 articles, and 21 met the inclusion criteria. A total of 855 subjects with ameloblastoma were included in the analysis. The pooled measures for frequency of BRAF V600E mutation was 65.30% (95% CI: 0.56–0.75; p < .001; I2 = 90.85%; τ = 0.205; p < .001), and the pooled recurrence rate was 25.30% (95% CI: 0.19–0.31; p < .001; I2 = 79.44%; τ = 0.118; p < .001). No differences in recurrence rate were observed between the BRAF V600E and wild type BRAF ameloblastomas, with a pooled Odds Ratio of 0.93 (95% CI: 0.56–1.54; p = .78; I2 = 31%; p = .09).ConclusionsBRAF V600E mutation is a frequent event in ameloblastomas, but does not increase nor reduce its recurrence rate, and thus have a limited value in predicting its prognosis.