bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of boundary conditions for coronary circulation model based on a lumped parameter approach
Authors: Simakov Sergey S. , Gamilov Timur M. , Liang Fuyou , Chomakhidze Petr Sh. , Kopylov Philipp Yu. 
Published: June 2023

Abstract
In the present work, we construct a model of coronary flow, which utilizes both CT scans of large coronary arteries and coronary CT perfusion. The model describes pulsatile flow in the patient’s network of coronary vessels and takes into account a number of physiological effects: myocardium contractions, stenoses, impairment of microvascular perfusion. The main novelty of this model is the new smooth boundary conditions that have not been used before in patient-specific simulations of coronary circulation. New boundary conditions use 0D lumped model approach and provide asymptotic convergence of the solution for the cases of one-to-one vascular connection and bifurcation with a very thin child vessel. The new boundary conditions make it possible to estimate the fractional flow margin more accurately. We also studied sensitivity of haemodynamic indices (fractional flow reserve, coronary flow reserve, instantaneous wave-free ratio) to the variations of microcirculation impairment. No substantial difference in sensitivity was observed between new model and original approach. The advantage of the presented approach is the availability of the required data in everyday clinical practice and, thus, improved personalization of the model.
Structure determination through powder X-ray diffraction, Hirshfeld surface analysis, and DFT studies of 2- and 4-(methylthio)benzoic acid
Authors: Chatterjee Paramita 
Published: June 2023

Abstract
2-(methylthio)benzoic acid (1) is an ortho-substituted benzoic acid derivative, whereas 4-(methylthio)benzoic acid (2) is a para-substituted benzoic acid derivative. The structural analysis of both compounds was carried out using PXRD data. 2-(methylthio)benzoic acid shows a triclinic system with the

P

1
‾

$P\overline{1}$

space group, whereas 4-(methylthio)benzoic acid shows a monoclinic system and crystallizes in the P21/a space group. The strength, as well as relative contributions of intermolecular hydrogen bonds, have been examined through Hirshfeld surfaces as well as 2D fingerprint plots. A weak intramolecular hydrogen bond was found only in the case of ortho-substituted 2-(methylthio)benzoic acid. Supramolecular frameworks for 1 are formed by the interplay of intramolecular and intermolecular interactions, whereas for 2, intermolecular contacts form supramolecular assemblies. Intermolecular O–H⋯O interactions involving carboxyl groups form the R2
2(8) graph-set motif for both compounds. Theoretical DFT calculations using the B3LYP correlation functional reveal that the energy gap of HOMO–LUMO orbitals in compound 1, with the methylthio moiety in the ortho position relative to the carboxyl group, is lower than that of compound 2, with the methylthio moiety in the para position. Vertical and adiabatic ionization energies are also calculated for both compounds.
A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans
Authors: Dobbelaere Jeroen , Su Tiffany Y , Erdi Balazs , Schleiffer Alexander , Dammermann Alexander 
Published: June 2023

AbstractCilia are cellular projections that perform sensory and motile functions in eukaryotic cells. A defining feature of cilia is that they are evolutionarily ancient, yet not universally conserved. In this study, we have used the resulting presence and absence pattern in the genomes of diverse eukaryotes to identify a set of 386 human genes associated with cilium assembly or motility. Comprehensive tissue‐specific RNAi in Drosophila and mutant analysis in C. elegans revealed signature ciliary defects for 70–80% of novel genes, a percentage similar to that for known genes within the cluster. Further characterization identified different phenotypic classes, including a set of genes related to the cartwheel component Bld10/CEP135 and two highly conserved regulators of cilium biogenesis. We propose this dataset defines the core set of genes required for cilium assembly and motility across eukaryotes and presents a valuable resource for future studies of cilium biology and associated disorders.
[SPA] ENTRE EL SERVICIO AL REY Y EL TRÁFICO DE EFECTOS: LA DOBLE NEGOCIACIÓN DE JUAN BAUTISTA DE ITURRALDE // BETWEEN THE SERVICE TO THE KING AND THE TRAFFIC EFFECTS: THE DOUBLE NEGOTATION OF JUAN BAUTISTA DE ITURRALDE
Authors: Dubet Anne 
Published: June 2023

En 1739, el Ministro de Hacienda Juan Bautista de Iturralde publica la suspensión de pagos más sonada del siglo XVIII, presentándola como un castigo a los culpables de beneficio de efectos de la Tesorería Mayor. Dos años después, es acusado de haber organizado desde 1725 una magna negociación basada en el tráfico de efectos, asociada a la adquisición «en empeño a gozar y gozar» de la renta de Población del reino de Granada. Examino la mecánica de la operación realizada en 1725 y la discusión que suscita. Las formas del crédito son inseparables de la influencia de los hombres de negocios en el gobierno de la Hacienda. Se trata de saber en virtud de qué criterios los actores distinguen entre el fraude y el servicio al rey y cómo se define la política de los Ministros de Hacienda frente al tráfico de efectos.PALABRAS CLAVE: Crédito, beneficio de efectos, fraude, renta de población de Granada, Juan Bautista de Iturralde, marqués de Murillo. ---In 1739, the Minister of Spanish Finance Juan Bautista de Iturralde publishes the most famous suspension of payments in the eighteenth century, justifying the decision as a punishment to the people guilty of trafficking the bills of the Treasurer General. Two years later, he is accused of having organized since 1725 an important business based on bills traffic associated with the acquisition «en empeño a gozar y gozar» of a fiscal contribution, the «Renta de Población» of the ancient kingdom of Granada. I study the business of 1725 and the discussion that it raises. Forms of royal credit are inseparable from the influence of businessmen in the government of the Treasury. It is interesting to know under what criteria the actors distinguished between fraud and service to the king and how the policy of the Finance Ministers against traffic effects was defined.KEY WORDS: Credit, bills traffic, fraud, renta de Población of Granada, Juan Bautista de Iturralde, marquis of Murillo.
[SPA] EL CORREO ORDINARIO Y EXTRAORDINARIO Y EL TRATADO DE LOS PIRINEOS // THE POSTAL SERVICE AND THE PEACE OF THE PYRENEES
Authors: Williams Lynn 
Published: June 2023

En este artículo se examina el funcionamiento del correo en España durante el siglo XVII, concretamente el uso que de él hace D. Luis Méndez de Haro al negociar con el cardenal Mazarino, en la frontera pirenaica, el tratado de paz de 1659. Además de enumerar los despachos que el valido prepara durante los cinco meses que está ausente de la corte, se señala su coste y, siempre que ha sido posible, el contenido de los mismos, así como la identidad de los destinatarios. Por último, se hace una valoración del servicio que prestan los correos reales y ordinarios durante la conferencia de paz y de su contribución al resultado de las negociaciones realizadas entre Haro y el cardenal.PALABRAS CLAVE: Siglo XVII, Pirineo, Conferencia de Paz, Correo.-- This article examines the functioning of the postal service in seventeenth-century Spain, specifically the way it is used by D. Luis Méndez de Haro as he negotiates the peace treaty of 1659 with Cardinal Jules Mazarin along the border between Spain and France. In addition to listing the dispatches the favourite prepares during the five months he is absent from court, precise information is given of their cost. Where possible, the addressee is identified and a summary of the dispatch supplied. Finally, consideration is given to the effectiveness of the postal service -both public and royal-during the peace conference, as well as to the contribution it makes to the final outcome of the negotiations. KEY WORDS: Spain, Seventeenth Century, Pyrenees, Peace Conference, Postal Service.
Residues of difenoconazole in various ready premixes with propiconazole, cyflufenamid, and mandipropamid in/on tomato fruits
Authors: Abdallah Osama I. , Ahmed Nevein S. , Abd El-Hamid Rania M. , Alhewairini Saleh S. 
Published: June 2023

AbstractResidues of the fungicides difenoconazole, propiconazole, cyflufenamid, and mandipropamid were determined in tomato fruit using acetonitrile for extraction and LC-MS/MS for quantification. Validation criteria include linearity range, the limit of detection (LOD) and limit of quantitation (LOQ), accuracy in terms of precision and trueness, and matrix effect were studied. The recovery rates of the method ranged from 91.8 to 106.3%. The precision of the method in terms of repeatability at one day (RSDr) and between three days (RSDR) ranged from 2.8 to 6.4% and from 4.3 to 7.6%, respectively, with good trueness from 92.2 to 96.4%. Matrix effects (suppression effects) ranged from 3.8% to 11.1%. The validated method was used to evaluate the dissipation kinetics of three different premix formulations: 30% EC (15% difenoconazole + 15% propiconazole), 14% DC (12.5% difenoconazole + 1.5% cyflufenamid), and 50% SC (25% difenoconazole + 25% mandipropamid) used on field tomatoes in Egypt. A first-order kinetic equation best describes residue dissipation. The calculated half-lives of difenoconazole, propiconazole, cyflufenamid, and mandipropamid were 2.01–2.27, 1.89, 1.97, and 1.71 days, respectively. The dissipation rate of difenoconazole did not differ significantly in the three premix formulations. Mandipropamid also dissipated faster compared to the other fungicides tested. The chronic dietary risk assessment results showed a minimal risk to adult Egyptian consumers. Waiting periods were advised for the safe consumption of tomatoes treated with the tested premix formulations.
Microfiltration Device For Circulating Tumor Cells Isolation (MEMS)-(CTCS)
Authors: González Alan , Borrás Pinilla Carlos 
Published: June 2023

Introduction: This document proposes the design and simulation of a microfilter device for the capture of circulating tumor cells, motivated by support for prevention and treatment methods against cancer, the objective of the proposal is the designed a device for separating cancer cells from blood fluid, with high efficiency.
Methods: Initially, it was characterized the behavior of cells in blood fluid red blood cells (RBC), white blood cells (WBC) cancer cells (CTC), defining the dynamic model, boundary conditions, types of multiphase fluid, and flow rate, the mechanical properties of the cell membrane and the viscosity of each type are defined, for cancer cells according to the literature, the cell was squeezed and the critical pressure was analyzed. The design of the filtration device by a variation of the flow, geometry, critical streamline analysis, and vortex generation, the best hydrodynamic condition generated is selected due to favorable behavior of cell classification, the first stage circulating cancer cells, in the second output white cells and RBCs are sorting.
Conclusions: Finally, the final geometry was evaluated and the efficiency of the filter device was determined, which performs the filtering process, in the first stage the cancer cells are captured with 99.99% efficiency, in the final output the white cells and red cells are captured 99.99% since the red cells are completely filtered and the white cells separated using the viscous properties and surface tension the filter generates 100% purity by sorting CTCs with no RBC or WBC contamination.
Augmented reality mobile information system for the obtaining detailed and non-intrusive information in large environments
Authors: Marceles Villlalba Katerine , Ortiz Martinez Elkin Faber , Benavides Zuñiga David Armando , Donado Siler Amador 
Published: June 2023

Introduction: This article is the result of the augmented reality project "AR position U" for the effective visualization of information of interest dynamically through augmented reality, carried out in the year 2022 in the city of Popayan, capital of the department of Cauca.
Problem: Problems have been identified regarding the location of spaces in very large places by people who have no knowledge of the site you need to locate causing loss of time, frustration to the point of being late to the desired location. This leads to the following problem question: What would be the impact of the implementation of an augmented reality application, whose purpose is to provide detailed information to people in a non-intrusive way in large environments?
Objective: To propose a mobile information system that allows users to orient themselves and obtain detailed information in a dynamic and non-intrusive way in large environments through augmented reality.
Methodology: The experimental methodology is used, since a series of tests were determined to reach the validation of the information system in order to have a product that was articulated with the guide of good practices of project management and meet the needs of the population to which it could be directed.
Results: As a result, the information system based on augmented reality was obtained, allowing the easy location of spaces due to the usability of the product.
Conclusion: Based on the experimental methodology it is determined that, although augmented reality improves the detailed descriptions of large environments, it is very limited to the external conditions, however, the tool meets the proposed objectives.
Originality: Augmented reality information system for orientation in large places and obtaining information in a non-intrusive way, under the PMBOK and XP methodology.
Limitations: Due to complexity and time constraints, it is not possible to cover all faculties. On the other hand, 3D interface is only generated by QR tags. On the other hand, the correct functioning of the system can be affected by lighting factors, the distance of the user from the tag, the hardware and software capacity of the smartphone and the internet connection.
FACTORS ASSOCIATED WITH TYPE 2 DIABETES MELLITUS AT ADAM MALIK GENERAL HOSPITAL, MEDAN, INDONESIA
Authors: Nababan Memo , Umbul Wahyuni Chatarina , Aguslina Siregar Fazidah 
Published: June 2023

Background: Diabetes mellitus is third highest cause of death in Indonesia with percentage 6.71%, and 2018 Indonesia was ranked seventh among the 10 countries with most diabetes with prevalence based on blood sugar level test results 8.56%. Adam Malik General Hospital is one of the hospitals with the highest percentage of diabetes in Medan with the cases reported by 1,323 people in 2020. Purpose: This study aimed to analyze the factors related to the incidence of diabetes at the Adam Malik General Hospital. Methods: This was a cross-sectional analytical design study. The study was conducted at Adam Malik General Hospital between April 22-May 4, 2021. The population of this study included all patients who went to internal medicine, while the sample part of the population (99 respondents) was sampled accidentally. The research instruments used were questionnaires, and data collection used primary and secondary data. Data were analyzed using the chi-square test. Results: Three variables were related to the incidence of DM at Adam Malik General Hospital: family history of DM (P =0.00; PR=3.03; 95% CI= <1.37 PR <2.73), physical activity (P =0.00; PR= 3.33; 95% CI= <1.59 PR <6.95), and age (P =0.00; PR= 0.19; 95%CI= <0.52, PR <0.71). Conclusion: This study is that there are three factors related to occurrence of diabetes, namely family history, physical activity, and age. It is necessary to carry out regular physical activity every day and conduct health checks, especially for those who have a family history of DM.
ANALYSIS OF DIARRHEA MANAGEMENT IN CHILDREN UNDER TWO YEARS OLD IN INDONESIA
Authors: Choirul Hidajah Atik , Astutik Erni 
Published: June 2023

Background: Diarrhea in children under two is still a severe problem in Indonesia, affecting achieving SDG target 3. Providing good care will reduce the risk of death in children caused by diarrhea. Purpose: This study aimed to analyze the relationship between socio-demographic characteristics, place of residence, and access to media in mothers with children under two years old and diarrhea management in children in Indonesia. Methods: This study used secondary data from the 2017 Indonesian Health Demographic Survey (DHS) with a cross-sectional study design. Analyzed were the responses of 1,061 mothers whose children under two had diarrhea in the two weeks before the survey. Samples were taken using two-stage sampling methods. The data were analyzed by chi-square and multiple logistic regression. Multiple logistic regression was adjusted for the complex sampling designs of DHS for data analysis. Results: 59.50% of children received inappropriate treatment. Older mothers (AOR 20–24 = 2.03, 95% CI = 1.03–3.98) who lived in rural areas (AOR = 1.41, 95% CI = 1.03–1.94), had access to several media (AOR = 2.03, 95% CI = 1.01–4.10), and all media (AOR = 2.23, 95% CI = 1.07–4.64), had higher odds of having a child whose diarrhea treatment was not appropriate after controlling for other variables. Conclusion: Mothers' age, residence, and access to media have a significant relationship with inappropriate diarrhea care for their children. Therefore, interventions need to focus on women who live in rural areas and have access to the media.
Conclusion: Mother’s age, residence, and access to media have a significant relationship with inappropriate diarrhea care for their children. Therefore, interventions need to focus on women who live in rural areas and have access to the media. It is hoped that this intervention can increase mother's knowledge to provide good care when her child has diarrhea.
RELATIONSHIP OF EXCLUSIVE BREASTFEEDING WITH UTERINE INVOLUTION POSTPARTUM AT PMB NISBAHNINGSIH
Authors: Fitriani Yunita , Farihatin Yuyun , Rukanah Rukanah 
Published: June 2023

Introduction: Process Breastfeeding affects the decrease in fundal height. that mother having impaired lactation will hinder the process of uterine involution which will result in bleeding. one way to prevent bleeding during puerperium is to give ASI as early as possible maybe the baby. Methods: This study uses an analytical method with a cross sectional approach. The sampling technique was non probability with accidental sampling method, where the researcher collected samples until fulfilled at PMB Nisbahningsih Gresik as many as 21 postpartum mothers. Results: The test results as many as 21 post partum mothers with statistical analysis used contingency coefficient test showed a p = 0.005 < α = 0.05, there was a significant the relationship of exclusive breastfeeding with uterine involution process in postpartum mothers at PMB Nisbahningsih gresik. Conclusions: The results of this study it can be concluded thah that there is a relationship between exclusive breastfeeding on uterine involution. Therefore it is expected that post partum mothers give exclusive breastfeeding to their babies so that the process of runs normally.
Artificial Lunate Arthroplasty for Kienböck Disease With Multiple Extensor Tendon Ruptures
Authors: Hayakawa Katsuya , Suzuki Taku , Furuhata Ryogo , Kimura Hiroo , Matsumura Noboru , Iwamoto Takuji , Nakamura Masaya 
Published: June 2023

Case:
A 73-year-old woman presented with wrist pain and loss of extension in the middle and ring fingers. Radiography revealed a dorsally displaced lunate fragment, resulting in a diagnosis of Kienböck disease with extensor tendon rupture. Artificial lunate replacement and tendon transfer were performed as treatment. Two years postoperatively, the pain was relieved, and the extension lag was 0°. The wrist motion and carpal height had also improved.

Conclusion:
Lunate excision, partial wrist arthrodesis, or proximal row carpectomy are known treatments for Kienböck disease with extensor tendon rupture. Lunate arthroplasty is a novel, useful treatment option for this condition.
The Effect of Pre-Endoscopy Maltodextrin Beverage on Gastric Residual Volume and Patient’s Well-being: A Randomised Controlled Trial
Authors: Zulkifli Mohd Firdaus , Has Mohd Nizam Md , Zahari Zalina , Wong Michael Pak-Kai , Aziz Syed Hassan Syed Abd , Yahya Maya Mazuwin , Zain Wan Zainira Wan , Zakaria Andee Dzulkarnaen , Ramely Rosnelifaizur , Yen Soh Jien , Othman Muhammad Faeid 
Published: June 2023

Abstract
Background: Prolonged fasting prior to oesophagogastroduodenoscopy (OGDS) could be noxious to patients well-being.
Aims:To determine the effect of maltodextrin beverage 2 hours before OGDS on gastric residual volume and patient’s well-being scores.
Methods: A single-blinded, stratified randomised controlled trial was performed, comparing control group (A, received 400 ml of plain water) and carbohydrate loading group (B, received 400 ml of Carborie®) in terms of gastric residual volume (GRV) and patient’s well-being scores (visual analogue scale (VAS)) scores for hunger, thirst, anxiety, tiredness and general discomfort).
Results: Of 80 randomised patients, 78 completed the study (38 received plain water and 40 Carborie®). The median (IQR) GRV was not significantly different between group A and B (5.0 ml (20) vs 4.0 ml (19)), p= 0.777). Both groups showed significant reduction in VAS scores in all five parameters (p≤ 0.001). There were no complications attributed to endoscopy in either group.
Conclusions: Pre-endoscopy maltodextrin beverage is as safe as clear water with improved patient’s well-being in the intervention group.
Identify Cytotoxic Activity in Phenolic Aqueous Extracts of Toona Sinensis Leaves via Mitochondrial Dysfunction Through the MEK/ERK Signaling Pathway in Human Glioblastoma Cells
Authors: Su Yu-Feng , Tsai Tai-Hsin , Kuo Keng-Liang , Wu Chieh-Hsin , Su Hui-Yuan , Chang Wen-Chang , Huang Fu-Long , Lieu Ann-Shung , Kwan Aij-Lie , Loh Joon-Khim , Lin Chih-Lung , Tsai Cheng Yu 
Published: June 2023

Abstract

Introduction: Toona sinensis is a traditional Chinese medicine commonly used in South-East Asia. The aqueous extracts of T. sinensis leaves (TSL) exhibit anticancer effects in various types of cancer. In this study, we assessed the effectiveness of TSL treatment for glioblastoma multiforme (GBM). Methods After treating A172 and U251 GBM with TSL, cell cycle and apoptotic cells were evaluated by flow cytometry, as well as anti-proliferative efficacy by MTT assay. Reactive oxygen species (ROS) and ATP production were quantified by CellROX, Dihydroethidium (DHE) and Tetramethylrhodamine methyl ester (TMRM). Apoptosis and MEK/ERK pathway related protein levels were detected by western blot. Results Gallic acid was demonstrated the major effective component in aqueous extracts in TSL under HPLC system and it could penetrate across blood-brain barrier. TSL treatment inhibited cell growth and proliferation and exerted cytotoxic effect in A172 and U251 GBM cells. Flow cytometry analysis revealed cell cycle arrest at G2/M and apoptotic cells. Mitochondrial dysfunction presented with excessive reactive oxygen species (ROS) and decreased ATP production via blockage of electron transport chain (ETC) complexes, leading to ROS-regulated mitochondrial dysfunction. Furthermore, Western blotting data indicated that TSL treatment upregulated the levels of Bax and Puma and downregulated the level of Bcl-2. Moreover, cleaved caspase-3, cleaved caspase-9, and cleaved PARP were induced to illustrate mitochondria-mediated apoptosis and caspase-dependent pathway under TSL treatment in two GBM cells. Finally, U0126 as an inhibitor of MEK/ERK kinase was applied to demonstrate that the MEK/ERK pathway was responsible for the inhibition of ROS-regulated mitochondrial dysfunction and promoted apoptosis. Conclusion TSL treatment suppressed MEK/ERK activation to induce apoptosis through antioxidant effect in GBM cells. This mechanism may provide a therapeutic potential in GBM therapy.