bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of accelerated T2 mapping for the preoperative assessment of endometrial carcinoma
Authors: Zhang Zanxia , Liu Jie , Wang Weijian , Zhang Yong , Qu Feifei , Hilbert Tom , Kober Tobias , Cheng Jingliang , Li Shujian , Zhu Jinxia 
Published: July 2023

ObjectiveThe application value of T2 mapping in evaluating endometrial carcinoma (EMC) features remains unclear. The aim of the study was to determine the quantitative T2 values in EMC using a novel accelerated T2 mapping, and evaluate them for detection, classification,and grading of EMC.Materials and methodsFifty-six patients with pathologically confirmed EMC and 17 healthy volunteers were prospectively enrolled in this study. All participants underwent pelvic magnetic resonance imaging, including DWI and accelerated T2 mapping, before treatment. The T2 and apparent diffusion coefficient (ADC) values of different pathologic EMC features were extracted and compared. Receiver operating characteristic (ROC) curve analysis was performed to analyze the diagnostic efficacy of the T2 and ADC values in distinguishing different pathological features of EMC.ResultsThe T2 values and ADC values were significantly lower in EMC than in normal endometrium (bothl p &lt; 0.05). The T2 and ADC values were significantly different between endometrioid adenocarcinoma (EA) and non-EA (both p &lt; 0.05) and EMC tumor grades (all p &lt; 0.05) but not for EMC clinical types (both p &gt; 0.05) and depth of myometrial invasion (both p &gt; 0.05). The area under the ROC curve (AUC) was higher for T2 values than for ADC values in predicting grade 3 EA (0.939 vs. 0.764, p = 0.048). When combined T2 and ADC values, the AUC for predicting grade 3 EA showed a significant increase to 0.947 (p = 0.03) compared with those of ADC values. The T2 and ADC values were negatively correlated with the tumor grades (r = -0.706 and r = -0.537, respectively).ConclusionQuantitative T2 values demonstrate potential suitability in discriminating between EMC and normal endometrium, EA and non-EA, grade 3 EA and grade 1/2 EA. Combining T2 and ADC values performs better in predicting the histological grades of EA in comparison with ADC values alone.
Preclinical PK investigation of a novel IDO1/TDO dual inhibitor—SHR9146 in mouse plasma and tissues by LC-MS/MS
Authors: Xiao Mei , Zhong Kan , Guo Li , Li Wei , Wang Xiaoli , Qiu Zhenjun , Hang Taijun 
Published: July 2023

PurposeThe aim of the present study was to establish a liquid chromatography–tandem mass spectrometry (LC-MS/MS) method for the determination of SHR9146, a novel IDO1/TDO dual inhibitor, in mouse plasma and tissues, and to apply it to investigate the preclinical plasma pharmacokinetics and tissue distribution of SHR9146 in mice.MethodsSamples were spiked with deuterated SHR9146-d4 as an internal standard and pretreated by protein-precipitation extraction with methanol. Chromatographic separation was performed on a Venusil ABS C18 column (150 × 4.6 mm, 5 μm) by isocratic elution with 10 mM ammonium acetate buffer containing 0.1% formic acid solution and methanol as mobile phases. MS detection was conducted in positive electrospray ionization with multiple reaction monitoring at m/z 444.1/229.4 for SHR9146 and m/z 448.4/229.2 for the internal standard.ResultsThe method showed good linearity in the calibration range from 0.05 to 50.0 μg/mL. Precisions (intra- and inter-run) were in the range from 0.5% to 5.1%, and accuracies (RE) were between −3.0% and 4.4% for all the concentration levels. SHR9146 was stable in all the tested bio-samples with recoveries &gt;90%. Pharmacokinetic parameters were obtained by non-compartmental analysis. SHR9146 has a half-life of 0.713 h when IV-injected, with CL 12 mL/min/kg and Vd 0.666 L/kg. After oral dosing from 20 to 80 mg/kg, Cmax (range from 8.751 to 12.893 μg/mL) and AUC0-t (range from 15.606 to 69.971 μg·h/mL) of SHR9146 showed dose proportionality. Other post-oral pharmacokinetic parameters in plasma were as follows (n=6): Tmax 0.79 ± 0.36 h, t1/2 1.586 ± 0.853 h, CL 19.8 ± 0.9 mL/min/kg, Vd 3.427± 1.617 L/kg, and absolute bioavailability of 54.2% ± 12.6% (range from 40.2% to 64.7%). In addition, SHR9146 was found to be absorbed rapidly and distributed widely and mainly in the stomach, adrenal gland, liver, and lung.ConclusionThe method was simple, sensitive, accurate, and specific and was successfully applied for the preclinical pharmacokinetic and tissue distribution study of SHR9146 in mice. The results showed that SHR9146 had dose-independent kinetics in mice via oral administration and was absorbed rapidly and distributed widely. The study provides a good basis for further drug development assessment.
Impact of BMI z-score on left ventricular mechanics in adolescent girls
Authors: Paysal Justine , Merlin Etienne , Rochette Emmanuelle , Terral Daniel , Nottin Stéphane 
Published: July 2023

BackgroundAdolescent weight disorders ranging from anorexia nervosa (AN) to obesity (OB) can impact the heart by causing opposite alterations in its morphology, suggesting a direct impact of body mass index (BMI) on the heart. Cardiac function is relatively preserved as assessed by standard echocardiography. However, few studies have used 2D speckle-tracking echocardiography (2D-STE), which can detect subtle alterations of left ventricular (LV) function by evaluating deformations. This study aimed to assess the link between the BMI z-score of adolescent girls and myocardial function.MethodsNinety-one adolescent girls comprising 26 AN patients (age 14.6 ± 1.9 years), 28 OB patients (age 13.2 ± 1.4 years), and 37 controls (age 14.0 ± 2.0 years) underwent 2D-STE to assess LV morphology and myocardial global and regional deformations.ResultsThe BMI z-score of our population ranged from −4.6 to 5.2. LV morphological remodeling was significantly and positively correlated with the BMI z-score (R2 = 0.456, p &lt; 0.0001 for LV mass). Global longitudinal strain (LS) and regional LS recorded at the mid and apical levels were significantly correlated with the BMI z-score (R2 = 0.196, p = 0.0001 and R2 = 0.274, p &lt; 0.0001, respectively, for apical and medial LS). Circumferential strains and twisting mechanics were not correlated with the BMI z-score. Fibrinogen and systolic blood pressure were the main variables explaining the alteration of LS.ConclusionWe observed that the BMI z-score had an impact on LV mechanics, especially on medial and apical LS. Neither circumferential nor twisting mechanics were altered by the BMI z-score in adolescent girls.
Effects of CYP3A4*22 polymorphism on trough concentration of tacrolimus in kidney transplantation: a systematic review and meta-analysis
Authors: Kim Jung Sun , Shim Sunyoung , Yee Jeong , Choi Kyung Hee , Gwak Hye Sun 
Published: July 2023

Purpose: Tacrolimus (Tac) is a widely used immunosuppressive agent in kidney transplantation. Cytochrome P450 (CYP), especially CYP3A4 enzymes are responsible for the metabolism of drugs. However, the correlation between plasma Tac concentration and CYP3A4*22 gene variants is controversial. This meta-analysis aims to evaluate the association between CYP3A4*22 polymorphism and the dose-adjusted trough concentration (C0/D) of Tac in adult kidney transplant patients.Methods: We conducted a literature review for qualifying studies using the PubMed, Web of Science, and Embase databases until July 2023. For the continuous variables (C0/D and daily dose), mean difference (MD) and corresponding 95% confidence intervals (CIs) were calculated to evaluate the association between the CYP3A4*22 and Tac pharmacokinetics. We performed an additional analysis on the relationship of CYP3A5*3 with Tac PKs and analyzed the effects of CYP3A4*22 in CYP3A5 non-expressers.Results: Overall, eight eligible studies with 2,683 renal transplant recipients were included in this meta-analysis. The CYP3A4*22 allele was significantly associated with a higher C0/D (MD 0.57 ng/mL/mg (95% CI: 0.28 to 0.86; p = 0.0001) and lower mean daily dose requirement (MD -2.02 mg/day, 95% CI: −2.55 to −1.50; p &lt; 0.00001). An additional meta-analysis demonstrated that carrying the CYP3A5*3 polymorphism greatly impacted Tac blood concentration. From the result with CYP3A5 non-expressers, CYP3A4*22 showed significant effects on the Tac C0/D and dose requirement even after adjusting the effect of CYP3A5*3.Conclusion: Patients with CYP3A4*22 allele showed significantly higher plasma C0/D of Tac and required lower daily dose to achieve the therapeutic trough level after kidney transplantation. These findings of our meta-analysis may provide further evidence for the effects of genetic polymorphism in CYP3A4 on the PKs of Tac, which will improve individualized treatment in a clinical setting.
Contraception, female cycle disorders and injuries in Swiss female elite athletes—a cross sectional study
Authors: Baumgartner Sabrina , Bitterlich Norman , Geboltsberger Sarah , Neuenschwander Maja , Matter Sibylle , Stute Petra 
Published: July 2023

Aim: The national Olympic committee of Switzerland has conducted an online survey among female elite athletes with a focus on cycle disorders, contraception, and injuries in 2021.Methods: A total of 1,092 female elite athletes from 107 different sports were asked to answer the questionnaire. A descriptive analysis was carried out to determine location parameters and create frequency tables.Results: The questionnaire was completed by 408 athletes (37.4%) from 92 different sports. 43.4% participated in a lean sport. 57.1% reported no injuries, 32.6% one injury, and 10.2% two or more injuries per year. A considerable proportion reported being affected by primary amenorrhoea (10.8%). Primary amenorrhoea occurred significantly more often in female athletes with a BMI lower than 21.7 kg/m2 (15.2%) than in athletes with a BMI above 21.7 kg/m2 (7.4%, p = 0.021). Considering contraception, 25.8% of female athletes were currently using an oral contraceptive pill. The proportion of female athletes not using contraception at all or using non-hormonal contraceptive methods was high at 54.4%. In lean sports, significantly more athletes used no or non-hormonal contraceptives (p &lt; 0.05).Conclusion: Among top Swiss female athletes, a considerable proportion used non-hormonal or no contraceptives. This trend was more evident in lean sports. Delayed menarche and cycle irregularities were common among female athletes, especially among athletes with high training volumes as well as a BMI below 21.7 kg/m2. This orienting survey underlines the importance of specialized gynecological care for elite female athletes.
Horticultural therapy for stress reduction: A systematic review and meta-analysis
Authors: Lu Shan , Liu Jianjiao , Xu Meijing , Xu Feng 
Published: July 2023

IntroductionHorticultural therapy has been increasingly accepted as a non-pharmacological stress reduction treatment. Previous studies have demonstrated its therapeutic effects, with the effect varying according to the populations, settings, and interventions of horticultural therapy. This study aimed to provide a comprehensive review of the current literature regarding the effectiveness of horticultural therapy in reducing stress.MethodsWe selected databases including PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure, and VIP Data as our data source, and the original search was completed in January 2023.ResultsOur results showed significantly increased effects of horticultural therapy on psychological indicators compared to a control group, but an insignificant effect on physiology indicators. The result of the subgroup analysis demonstrated that the stress-reducing effects of horticultural therapy were related to the characteristics of the population and indoor and virtual areas were the most effective setting for horticultural therapy. At the same time, a total duration of 100–500 minutes provided better effects of stress reduction.DiscussionWe also developed a theoretical framework based on a “Participants-Settings-Interventions” structure for horticulture therapy in terms of its stress-reduction effects, to provide a reference for future horticultural therapy activities.
Influence of preparedness on caregiver burden, depression, and quality of life in caregivers of people with disabilities
Authors: Uhm Kyeong Eun , Jung Heeyoune , Woo Min Woo , Kwon Hyo Eun , Oh-Park Mooyeon , Lee Bo Ram , Kim Eun Joo , Kim Jung Hwan , Lee Seung Ah , Lee Jongmin 
Published: July 2023

IntroductionCaregiver preparedness is defined as the perceived preparation of caregivers to care for the physical and emotional needs of the patient.PurposeThis study investigated caregiver preparedness and its influences on caregiver burden, depression, and quality of life (QoL) in caregivers of individuals with disabilities.MethodsWe conducted a multicenter cross-sectional survey study on caregivers caring for patients with disabilities. Sociodemographic characteristics were collected via questionnaires. The Preparedness for Caregiving Scale (PCS), Burden Interview (BI), Center for Epidemiologic Studies Depression Scale (CES-D), and EuroQol-Visual Analogue Scale (EQ-VAS) were administered.ResultsA total of 151 caregivers were enrolled. The mean age of caregivers was 53.7 ± 12.4 years, and 80.8% were female. The majority of participants were the main caregivers of patients with stroke, spinal cord injury, or traumatic brain injury. The mean PCS score was 2.1 ± 0.9, demonstrating significant relationships with BI (r = −0.512, p &lt; 0.001), CES-D (r = −0.622, p &lt; 0.001), and EQ-VAS (r = 0.441, p &lt; 0.001). The CES-D was significantly associated with the PCS after controlling other variables. However, PCS did not show any correlation with the duration of caregiving or amount of time spent per day on caregiving.DiscussionThe clinical implications of this study are that higher caregiver preparedness is a predictor of less caregiver burden and depression, and better QoL. However, preparedness did not increase as the duration or time spent on caregiving was extended. Therefore, efforts to enhance the caregivers’ preparedness are required to reduce caregiver burden and improve health outcomes for both caregivers and patients.
Low antiretroviral therapy uptake and low early retention among pregnant women who tested positive for human immunodeficiency virus in informal health centers in urban and semi-rural settings in Cameroon: a prospective cohort study
Authors: Onambele Audrey Amboua Schouame , Yuya Francis , Schouame Arielle Andtoungou , Nolna Sylvie Kwedi , Socpa Antoine 
Published: July 2023

IntroductionDespite the efforts of Cameroon’s Ministry of Public Health against informal health centers (IHCs) because of their illegitimacy, the number of IHCs is increasing in Cameroon. Most of these IHCs have antenatal care services and screen pregnant women for HIV. However, nothing is known about the subsequent outcomes of those who tested positive for HIV. This study aimed to assess the initiation of antiretroviral therapy (ART) in ART-naïve pregnant women screened HIV positive in IHCs within three months of diagnosis and their ART retention at three months post-initiation. In addition, we sought to identify the factors associated with ART non-initiation in this population.MethodsMay 01, 2019 to August 31, 2020, we carried out a prospective cohort study of ART-naïve pregnant women who attended their first antenatal care visit and screened HIV positive at IHCs in the cities of Douala and Ebolowa in Cameroon. Standardized questionnaires were used to interview consenting participants at three points: the day of the delivery of the antenatal HIV test result, three months later, and three months after ART initiation. The data collected were entered into KoboCollect and analyzed using SPSS V23.0 software. The Chi-square test was used to compare proportions, Kaplan Meier techniques and Cox proportional hazards regression was used to estimate retention in ART and identify factors associated with ART non-retention, respectively.Results and discussionA total of 85 ART-naïve pregnant women living with HIV were enrolled in the study. The median age and gestational age at the first antenatal care visit were 29 years (interquartile range (IQR), 2333.5) and 28weeks of amenorrhea (IQR, 2032), respectively. Only 34% (29/85) initiated ART, and 65.5% (19/29) of the initiators were retained in ART three months later. Lack of perceived self-efficacy to initiate ART (adjust Hazard Ratio = 5.57, 90% CI: 1.29 to 24.06), increased the probability of not be retaining in ART by any time during three months post initiation. Given the low ART uptake and the low retention in care among pregnant women living with HIV screened in IHCs, PMTCT policies in Cameroon should pay greater attention to this population, to facilitate their continuum of PMTCT care.
Temporal perception is distorted by submaximal and maximal isometric contractions of the knee extensors in young healthy males and females
Authors: Gardner Hayley R. , Konrad Andreas , Alizadeh Shahab , Graham Andrew , Behm David G. 
Published: July 2023

IntroductionThe estimate of time (temporal perception) is important for activities of daily living, sports and even survival, however time perception research needs greater scrutiny. Time estimation can influence movement decisions and determine whether the individual is successful at their goal, The objectives of this study were to examine participants perception of time at 5-, 10-, 20-, and 30-s intervals to determine possible distortions of time estimates caused by varying intensity isometric contractions, and sex differences.MethodsIn this repeated measures study, 19 participants (10 females, 9 males) endured two sessions, which consisted of a cognitive task of estimating time intervals while performing an isometric knee extension at maximal, submaximal (60%), and distraction (10%) intensities and a non-active control. In addition to time estimates; heart rate (HR), tympanic temperatures and electromyography during the intervention contractions were monitored. Maximal contractions induced significantly greater time underestimations at 5-s (4.43 ± 0.93,p = 0.004), 20-s (18.59 ± 2.61-s,p = 0.03), and 30-s (27.41 ± 4.07-s,p = 0.004) than control. Submaximal contractions contributed to time underestimation at 30-s (27.38 ± 3.17-s,p = 0.001). Females demonstrated a greater underestimation of 5-s during the interventions than males (p = 0.02) with 60% submaximal (−0.64-s ± 0.26) and distraction (−0.53-s ± 0.22) conditions. For the other 10-, 20-, 30-s intervals, there was no significant time perception sex differences. The control condition exhibited lower HR (75.3 ± 11.6) than the maximal (92.5 ± 13.9), 60% submaximal (92.2 ± 14.4) or distraction (90.5 ± 14.7) conditions. Tympanic temperatures were not influenced by the contraction intensities.DiscussionThere was greater integrated knee extensor electromyographic activity during the maximal contractions to suggest greater neuromuscular activation that may influence time perception. However, there was no consistent effect of changes in HR or temperature on time estimates. This work adds to the growing literature of time perception during exercise to state that time is significantly underestimated when performing moderate to vigorous intensity exercise.
Food Insecurity, Healthcare Utilization, and Healthcare Expenditures: A Longitudinal Cohort Study
Authors: Choe Hwi , Pak Tae-Young 
Published: July 2023

Objective: This study examines the longitudinal association between household food insecurity and healthcare utilization and expenditure.Methods: A multi-wave longitudinal cohort study was conducted using the 2008–2019 and 2021 waves of the Korean Welfare Panel Study. The baseline data included participants aged ≥19 years with valid responses to the food insecurity and healthcare questionnaires in the 2008 wave (n = 12,166). Healthcare outcomes encompassed outpatient visits, inpatient admissions, days hospitalized, and personal healthcare expenditure. Random effects Poisson and linear regressions were estimated.Results: Severe food insecurity was associated with a higher incidence rate of outpatient visits (IRR, 1.14; 95% CI, 1.12–1.17), days of hospitalization (IRR, 1.18; 95% CI, 1.13–1.22), and inpatient admissions (IRR, 1.40; 95% CI, 1.18–1.65). Moderate food insecurity was associated with 10.4% (β = −0.11; 95% CI, −0.14 to −0.07) or 238,276 KRW reductions in personal healthcare expenditures in the subsequent year.Conclusion: Household food insecurity was linked to increased healthcare utilization and reduced personal healthcare expenditure among Korean adults. Our findings present opportunities to identify target populations for healthcare policies and interventions.
Improving the Estimation of the Occurrence Time of an Impending Major Earthquake Using the Entropy Change of Seismicity in Natural Time Analysis
Authors: Varotsos Panayiotis A. , Sarlis Nicholas V. , Skordas Efthimios S. , Nagao Toshiyasu , Kamogawa Masashi , Flores-Márquez E. Leticia , Ramírez-Rojas Alejandro , Perez-Oregon Jennifer 
Published: July 2023

This article is focused on a new procedure concerning a more accurate identification of the occurrence time of an impending major earthquake (EQ). Specifically, we first recapitulate that, as was recently shown [P. Varotsos et al., Communications in Nonlinear Science and Numerical Simulation 125 (2023) 107370], natural time analysis of seismicity supplemented with the non-additive Tsallis entropy Sq leads to a shortening of the time window of an impending major EQ. This has been shown for the Tohoku mega-EQ of magnitude M9 that occurred in Japan on 11 March 2011, which is the largest event ever recorded in Japan. Here, we also show that such a shortening of the time window of an impending mainshock can be achieved for major, but smaller EQs, of the order of M8 and M7. In particular, the following EQs are treated: the Chiapas M8.2 EQ, which is Mexico’s largest EQ for more than a century that took place on 7 September 2017 near the coast of Chiapas state in Mexico, the 19 September 2017 M7.1 EQ that occurred within the Mexican flat slab, and the M7.1 Ridgecrest EQ on 6 July 2019 in California.
Precursor oscuro, Panesi
Authors: Donato Elena 
Published: July 2023

Las fuerzas adversas (hacia y desde el relato) que se encuentran en el título La seducción de los relatos (2018) designan el equívoco en el cual Jorge Panesi lee una región polémica del presente de la crítica literaria en Argentina, una dinámica con la que a la vez perfila su matriz histórica. “Relato” nombra, en su equivocidad, la forma actual de la polaridad propia del movimiento expansivo de la crítica argentina: literatura y política. Esta genealogía revela su intensidad en las resonancias de ese movimiento paradojal, que hacen visible una consciencia de sí de la crítica y tienen como condición el estilo de pensamiento crítico de Panesi, un procedimiento constructivo cuyo operador es el tiempo: la ética crítica de la ironía.