bluuebunny/crossref_metadata_2025_split huggingface dataset:
Divergent Construction of N‐Doped Polycyclic Aromatic Hydrocarbons with Indole as the Nitrogen Source Building Block
Authors: Bao Ming , Xie Xiongda , Huang Jingjing , Doyle Michael P. , Ren Zhi , Yue Haibo , Xu Xinfang 
Published: January 2023

AbstractAn Ag/Au‐catalyzed divergent cascade reaction of alkyne embedded diazoketones with indoles has been described. Preliminary mechanistic studies indicate that the reaction goes through a [4+2]‐cycloaddition of an in situ formed isobenzopyrylium intermediate with indole, followed by a sequential retro‐Michael addition/carbene N−H insertion process to give the benzo[i]phenanthridines products with gold catalysis; whereas a dearomatization/rearomatization sequence occurs favourably when the reaction is catalyzed by a silver catalyst, delivering benzo[b]carbazoles in generally high to excellent yields. Notably, this is a rare example of using indole as the dienophile for cycloaddition with the isobenzopyrylium species, providing a concise and practical approach for the selective construction of N‐doped polycyclic aromatic hydrocarbons (PAHs) with structural diversity and broad functional‐group compatibility.
The prognostic role of 1q21 gain/amplification in newly diagnosed multiple myeloma: The faster, the worse
Authors: Wang Yawen , Xu Jiadai , Xu Bei , Li Panpan , Yang Yang , Wang Wenjing , Xu Tianhong , Maihemaiti Aziguli , Lan Tianwei , Wang Pu , Ren Liang , Zhou Chi , Aihemaiti Xianmuseye , Liu Peng 
Published: January 2023

AbstractBackgroundThe prognostic value of additional copies of chromosome 1q (1q gain/amplification [amp]) in multiple myeloma (MM) remains controversial. In the meantime, the kinetics of the response to MM therapy has long been an area of debate. Few studies have pointed out the relationship of response kinetics with cytogenetic abnormalities (CAs) in MM.MethodsThe authors retrospectively analyzed the data of 1068 real‐world newly diagnosed MM patients from a Chinese national medical center.ResultsOverall, 405 (51.9%) patients had 1q gain/amp, with aggressive clinical characteristics and significant inferior survival. The variation in copy number (CN) of 1q (CN = 3 or CN >3) had no significant impact on the survival of MM patients with 1q abnormalities. No difference was found in the outcome of 1q gain/amp patients treated with doublet or triplet regimens. Upfront autologous stem cell transplantation could eliminate the adverse prognostic effect of 1q gain but not 1q amp. The duration from diagnosis to the first time achieving very good partial response (VGPR) or better was significantly shorter in patients with 1q gain/amp (77 days vs. 100 days, p = .001). Finally, multifactor regression analysis was performed to construct a new risk stratification model in MM patients with 1q gain/amp, which was validated in the Multiple Myeloma Research Foundation CoMMpass study cohort and worked better than the Revised International Staging System and Second Revision of the International Staging System (Harrell's concordance index: 0.631 vs. 0.598 and 0.537).ConclusionsIn the setting of novel therapy, 1q gain/amp still acts as an independent adverse prognostic factor. Patients with 1q gain/amp achieved VGPR rapidly but had inferior survival.
Effect of neonatal seizure burden and etiology on the long‐term outcome: data from a randomized, controlled trial
Authors: Trowbridge Sara K. , Condie Lois O. , Landers Jessica R. , Bergin Ann M. , Grant Patricia E. , Krishnamoorthy Kalpathy , Rofeberg Valerie , Wypij David , Staley Kevin J. , Soul Janet S. ,   for the Boston Bumetanide Trial Group
Published: January 2023

AbstractBackgroundNeonatal seizures are common, but the impact of neonatal seizures on long‐term neurologic outcomes remains unclear. We addressed this question by analyzing data from an early‐phase controlled trial of bumetanide to treat neonatal seizures.MethodsNeonatal seizure burden was calculated from continuous video‐electroencephalogram data. Neurologic outcome was determined by standardized developmental tests and postneonatal seizure recurrence.ResultsOf 111 enrolled neonates, 43 were randomized to treatment or control groups. There were no differences in neurologic outcomes between treatment and control groups. A subgroup analysis was performed for 84 neonates with acute perinatal brain injury (57 hypoxic–ischemic encephalopathy [HIE], 18 stroke, 9 intracranial hemorrhage [ICH]), most of whom (70%) had neonatal seizures. There was a significant negative correlation between seizure burden and developmental scores (p < 0.01). Associations between seizure burden and developmental scores were stronger in HIE and stroke groups compared with ICH (p < 0.05).ConclusionBumetanide showed no long‐term beneficial or adverse effects, as expected based on treatment duration versus duration of neonatal seizures. For neonates with perinatal brain injury, higher neonatal seizure burden correlated significantly with the worse developmental outcome, particularly for ischemic versus hemorrhagic brain injury. These data highlight the need for further investigation of the long‐term effects of both neonatal seizure severity and etiology.
Hybrid optimization enabled deep learning and spark architecture using big data analytics for stock market forecasting
Authors: Kanchanamala Pendela , Karnati Ramesh , Bhaskar Reddy Palagiri Vijaya 
Published: January 2023

SummaryThe precise forecasting of stock prices is not possible because of the complexity and uncertainty of stock. The effectual model is needed for the triumphant assessment of upcoming stock prices for several companies. Here, an optimized deep model is utilized to effectively predict the stock market using the spark framework. Here, the data partitioning is done using deep embedded clustering, wherein the tuning of parameters is done using the proposed Jaya Anti Coronavirus Optimization (JACO) algorithm in the master node. The proposed JACO is developed by combining Jaya Algorithm and Anti‐Coronavirus Optimization algorithm. Then, important technical indicators are mined from divided data in slave nodes. Here, the technical indicators are considered features for enhanced processing. Then, data augmentation is done to make data suitable for processing in the master node. At last, the prediction was done in the master node using deep long short‐term memory (Deep LSTM), and training is performed with the proposed JACO. The proposed JACO‐based Deep LSTM attains the smallest mean absolute error of 0.113, mean squared error of 0.095, and root mean squared error of 0.309.
Cryogenic Chemistry and Quantitative Non‐Thermal Desorption from Pure Methanol Ices: High‐Energy Electron versus X‐Ray Induced Processes
Authors: Torres‐Díaz Daniela , Basalgète Romain , Bertin Mathieu , Fillion Jean‐Hugues , Michaut Xavier , Amiaud Lionel , Lafosse Anne 
Published: January 2023

AbstractX‐Ray irradiation of interstellar ice analogues has recently been proven to induce desorption of molecules, thus being a potential source for the still‐unexplained presence of gaseous organics in the coldest regions of the interstellar medium, especially in protoplanetary disks. The proposed desorption mechanism involves the Auger decay of excited molecules following soft X‐ray absorption, known as X‐ray induced electron‐stimulated desorption (XESD). Aiming to quantify electron induced desorption in XESD, we irradiated pure methanol (CH3OH) ices at 23 K with 505 eV electrons, to simulate the Auger electrons originating from the O 1s core absorption. Desorption yields of neutral fragments and the effective methanol depletion cross‐section were quantitatively determined by mass spectrometry. We derived desorption yields in molecules per incident electron for CO, CO2, CH3OH, CH4/O, H2O, H2CO, C2H6 and other less abundant but more complex organic products. We obtained desorption yields remarkably similar to XESD values.
Electron Beam Etching of Cellulose Microgels for Absorptive Separation of DMSO from Reactions of 5‐Hydroxymethylfurfural Synthesis
Authors: Dong Xiaohan , Sheng Keyan , Chen Zhiyan , Guo Changhao , Huang Jiang , Gu Yanlong 
Published: January 2023

AbstractInvited for this month′s cover is the groups of Jiang Huang and Yanlong Gu at Huazhong University of Science and Technology. The image shows a new method for the separation of dimethyl sulfoxide from a reaction solution of synthesizing 5‐hydroxymethylfurfural by means of using a cellulose microgel fabricated by electron beam irradiation as a bio‐based absorbant. The Research Article itself is available at 10.1002/cssc.202201755.
Factors affecting the occupancy of Chinese pangolins (Manis pentadactyla) suggest a highly specialized ecological niche
Authors: Dhami Bijaya , Neupane Bijaya , Devkota Bishnu Prasad , Maraseni Tek , Sadadev Bipana Maiya , Bista Shreyashi , Adhikari Amit , Chhetri Nar Bahadur , Panta Melina , Stewart Alyssa B. 
Published: January 2023

AbstractThe Chinese pangolin is a critically endangered and biologically unique species, yet information on its status, distribution, and habitat preferences is still scarce in Nepal, which limits effective conservation action. This study identified the current burrow density status, distribution pattern, and important habitat parameters associated with Chinese pangolin distribution in Nepal through opportunistic field surveys. Fifty‐four belt transects were examined for the presence of pangolin burrows. For each active burrow (burrow with freshly dug soil, footprints, and scat near the entrance) and old burrow (burrow with compacted soil, presence of dead leaves, and spider web in the entrance), we recorded the geographic coordinates and assessed data on 11 habitat parameters that included elevation, aspect, slope, canopy cover, ground cover, presence or absence of ant and termite colonies, habitat type, soil type, and distances to the nearest water source, road, and settlement. A total of 141 active burrows and 430 old burrows were recorded with an overall clumped distribution . Active burrow density was estimated to be 1.04 burrows/ha. Of the 11 habitat parameters predicted to influence the probability of encountering pangolin burrows, all parameters were significant except elevation. More than 92% of the burrows were found at elevations between 450 and 750 m and facing either the SE or NW aspect. Similarly, about 90% of the burrows were distributed in areas having slopes between 0% and 30% with moderate to high canopy and ground cover, and located close to water sources, roads, and settlements. Additionally, they strongly preferred forest habitats (with Shorea robusta, Castanopsis indica, Schima wallichii, Clerodendron infortunatum, and Nephrolepis auriculata as the dominant vegetation), areas with red soil, and areas located near ant and termite colonies. Although the study area currently provides suitable habitat for Chinese pangolins, it is slowly being degraded due to increasing rates of forest degradation. Conservation efforts should be increased in order to protect this critically endangered species and their preferred habitats. Finally, our findings reveal the preferred habitat characteristics of Chinese pangolins, which could be instrumental for policy makers and forest managers in making conservation plans for Chinese pangolins.
Narrow Band Gap Compounds with β‐Pyrochlore Structure in the A2O‐V2O5‐2TeO3 (A=Rb, Cs) System
Authors: Fukina Diana G. , Shotina Valeria A. , Boryakov Aleksey V. , Telegin Sergey V. , Volkova Natalia S. , Koroleva Aleksandra V. , Zhizhin Evgeny V. , Suleimanov Evgeny V. 
Published: January 2023

AbstractTwo new isostructural compounds with composition of Rb+V3+0.125V5+0.625Te6+1.25O6 and Cs+V3+0.125V5+0.625Te6+1.25O6 have been synthesized by solid‐state reaction. The crystal structure has been determined by X‐ray diffraction analysis using Rietveld refinement. Both compounds possess β‐pyrochlore structure‐type with cubic space group Fd‐3 m (Z=8); the unit cell parameters: a=10.04120(27) Å for RbV0.75Te1.25O6 Å and a=10.09119(23) Å for CsV0.75Te1.25O6. The oxidation states of vanadium and tellurium have been confirmed by X‐ray photoelectron spectroscopy. The compounds contain vanadium in mixed valence state (3+ and 5+). The compounds possess the unusual narrow band gap for oxide compounds – in the infrared (IR) range (∼0.6 eV). The schematic electronic structure of the compounds has been estimated using XPS, UPS and electronic conductivity data; however, the shifts of the top of the valence edge and the bottom of the conduction band in the water conditions have been calculated using theoretical approximation. The thermal behavior of obtained compounds has been studied by differential thermal analysis. RbV0.75Te1.25O6 and CsV0.75Te1.25O6 melts at low temperatures (∼500 °C) with decomposition and weight loss. The RbV0.75Te1.25O6 powder decomposes to amorphous phase, whereas CsV0.75Te1.25O6 transform into new β‐pyrochlore compound with another composition.
Ruthenium‐Catalyzed Regioselective 1,2‐Hydrosilylation of N‐Heteroarenes
Authors: Ma Xinyuan , Mane Manoj V. , Cavallo Luigi , Nolan Steven P. 
Published: January 2023

AbstractAn efficient method for the regioselective 1,2‐hydrosilylation of N‐heteroarenes is reported utilizing silanes as the hydride donor. The ruthenium complex [RuCl(PPh3)2(η5‐(3‐phenylindenylidene))], a versatile catalyst is, for the first time, employed in this catalytic reaction. The catalyst displays high catalytic efficiency at low loading and operates under mild conditions. This catalytic approach showcases high compatibility and regioselectivity with quinolines bearing different substituents and related N‐ heterocyclic compounds. The mechanism of this transformation was probed by performing stoichiometric reactions and examined using DFT calculations.
A systematic review on resource provisioning in fog computing
Authors: Kaur Kirandeep , Singh Arjan , Sharma Anju 
Published: January 2023

AbstractResource provisioning is allocating resources to clients over the Internet and plays a prominent role in cloud computing infrastructure‐as‐a‐service (IaaS). The main issues of resource provisioning are meeting user demands like bandwidth, response time, throughput, availability, and so on. The cloud computing framework uses virtualization technology to provide on‐demand access to computer system resources, specifically computation and storage. In cloud computing, computing resources are shared across another communication network using virtualization. However, the cloud computing mechanism cannot meet the needs of a large number of Internet of Things (IoT) services. To consider this, fog computing was introduced as a modified mechanism of the cloud paradigm by providing cloud services for the end devices. Fog computing is a decentralized computing model placed between devices, edges, data centers or the cloud. In this way, it helps to meet the demands initiated by IoT services, such as reduced latency, wide mobility coverage, and so on. Several solutions regarding resource allocation in fog computing are available in the research field, but such solutions have not achieved satisfactory results. Therefore, finding a solution by analyzing recent problems is open research. Therefore, this paper reviews different methods established for resource provisioning in fog computing using different parameters from 2015 to 2021 and introduces the limitations, advantages and future directions related to different resource provisioning techniques.
Sarcomatoid renal cell tumor harboring a novel BYSL::TFEB fusion with concurrent TFEB amplification
Authors: Lin Ruihe , Flerova Elizaveta , Wamsley Christine E. , McCue Peter A. , Lallas Costas D. , Jiang Wei , Huang Jialing , Wang Zi‐Xuan , Li Li 
Published: January 2023

AbstractTranscription factor EB (TFEB)‐rearranged renal cell carcinoma (RCC) exhibits diverse gene fusion patterns and heterogeneous clinicopathologic features. Rare TFEB‐amplified RCCs have been described recently and are associated with a more aggressive clinical course. Herein, we report a case of an 86‐year‐old man with a solid 9.2‐cm kidney tumor that showed a diffuse high‐grade sarcomatoid morphology. The tumor demonstrated a novel BYSL::TFEB fusion containing exons 1–2 of the BYSL gene fused to exons 3–10 of TFEB via next‐generation sequencing by using NextSeq sequencer. Fluorescence in situ hybridization (FISH) studies displayed concurrent high‐copy number TFEB amplification in two distinct patterns, a balanced increase of 5′ and 3′ copies, and solely increased 5′ copies, and mouse double minute 2 (MDM2) gene amplification by using TFEB (6p21.1) dual‐color break‐apart probe and MDM2 FISH probe. Notably, the tumor showed a distinctive immunoprofile with overexpressions of TFEB, epithelial membrane antigen, Cathepsin K, and PDL‐1 (SP263). FISH test for transcription factor binding to IGHM enhancer 3 (TFE3) was negative for rearrangement and corresponding immunonegativity of TFE3. These findings not only expand the repertoire of known TFEB fusion partners implicated in tumorigenesis, but also may provide novel information for target therapy.
Retracted: Gut microbiota and COVID‐19: A systematic review
Authors: SeyedAlinaghi SeyedAhmad , Afzalian Arian , Pashaei Zahra , Varshochi Sanaz , Karimi Amirali , Mojdeganlou Hengameh , Mojdeganlou Paniz , Razi Armin , Ghanadinezhad Farzaneh , Shojaei Alireza , Amiri Ava , Dashti Mohsen , Ghasemzadeh Afsaneh , Dadras Omid , Mehraeen Esmaeil , Afsahi Amir Masoud 
Published: January 2023

AbstractBackground and AimsAlteration in humans' gut microbiota was reported in patients infected with severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). The gut and upper respiratory tract (URT) microbiota harbor a dynamic and complex population of microorganisms and have strong interaction with host immune system homeostasis. However, our knowledge about microbiota and its association with SARS‐CoV‐2 is still limited. We aimed to systematically review the effects of gut microbiota on the SARS‐CoV‐2 infection and its severity and the impact that SARS‐CoV‐2 could have on the gut microbiota.MethodsWe searched the keywords in the online databases of Web of Science, Scopus, PubMed, and Cochrane on December 31, 2021. After duplicate removal, we performed the screening process in two stages; title/abstract and then full‐text screening. The data of the eligible studies were extracted into a pre‐designed word table. This study adhered to the PRISMA checklist and Newcastle−Ottawa Scale Bias Assessment tool.ResultsSixty‐three publications were included in this review. Our study shows that among COVID‐19 patients, particularly moderate to severe cases, the gut and lung microbiota was different compared to healthy individuals. In addition, the severity, and viral load of COVID‐19 disease would probably also be influenced by the gut, and lung microbiota's composition.ConclusionOur study concludes that there was a significant difference in the composition of the URT, and gut microbiota in COVID‐19 patients compared to the general healthy individuals, with an increase in opportunistic pathogens. Further, research is needed to investigate the probable bidirectional association of COVID‐19 and human microbiome.
Comprehensive analysis of radiation impact on the transfer of heat and mass micropolar MHD free convective fluid flow across a stretching permeability sheet with suction/injection
Authors: Saidulu B. , Reddy K. Sreeram 
Published: January 2023

AbstractAs part of our research, we investigate the analysis influence of radiation on heat and mass transfer free convection of micropolar MHD fluids over a stretched porosity sheet involving suction and injection. The governing energy, rotational momentum, and concentration and momentum partial differential equations are transformed into ordinary differential equation ones via a similarity transformation. This system of equations is then solved by using MATLAB's built‐in solver. The Sherwood numbers, Nusselt, friction factor, wall couple shear stress, and dimensionless profiles are all influenced by the various physical parameters of the flow. When the material parameter is increased, velocity rises but decreases when the magnetic parameter and surface condition factor are increased.
Co‐drug development of gallic acid and metformin targeting the pro‐inflammatory cytokines for the treatment of breast cancer
Authors: Kumar Vikas , Sharma Kalicharan , Sachan Richa , Alhayyani Sultan , Al‐abbasi Fahd A. , Singh Richa , Anwar Firoz 
Published: January 2023

AbstractIt is well‐documented that pro‐inflammatory cytokines and inflammation play a significant role in the expansion of cancer disease. Gallic acid (GA), a natural compound, and metformin (Met), a synthetic drug exhibit potent anticancer potential via the distinct molecular mechanism. However, whether both these compounds can act synergistically to preclude and treat cancer is still unknown. This prompted us to scrutinize, the synergism between GA and Met, and that of a new co‐drug synthesizing of GA and Met (GA‐Met) and investigated the chemo‐protective effect against breast cancer with possible intervention of cytokines. In vivo studies were based on chemical carcinogenesis, challenging breast tissue by dimethylbenz[α]anthracene (DMBA). Tumour incidence, tumour burden, pro‐inflammatory cytokines in serum, breast, hepatic tissue, macroscopically and histological analysis of mammary tumours were carried out and estimated. GA, Met and GA‐Met co‐drug exhibited the inhibition of cell proliferation; higher reduction of cell proliferation was observed by GA‐Met. The inhibitory effect of GA‐Met was linked to cell cycle arrest at G0/G1 phase, along with induction of apoptosis and accumulation in the sub‐G1 phase. GA‐Met significantly inhibited the cytokines production along with protection against DMBA‐induced hyperplasia. Taken altogether, the current result suggests that GA‐Met co‐drug endows a safe and protective effect against cancer metastasis and can possibly use for the treatment of human breast cancer.
Electronic and magnetic properties of TATA‐DNA sequence driven by chemical functionalization
Authors: Salgado‐Blanco Daniel , Flores‐Saldaña Diana S. M. , Jaimes‐Miranda Fabiola , López‐Urías Florentino 
Published: January 2023

AbstractThe TATA box is a promoter sequence able to interact directly with the components of the basal transcription initiation machinery. We investigate the changes in the electronic and magnetic properties of a TATA‐DNA sequence when functionalized with different chemical groups; using the first‐principles density functional theory specifically, the TATA‐DNA sequences were functionalized with methyl groups (CH3, methylation), amino groups (NH2, amination), imine groups (NH, imination), chloroamine groups (NCl2, chloramination), H‐adatom (hydrogenation), and Cl‐adatom (chlorination). The functional groups were anchored at nitrogen atoms from adenine and oxygen atoms from thymine at sites pointed as reactive regions. We demonstrated that chemical functionalization induces significant changes in charge transfer, hydrogen bond distance, and hydrogen bond energy. The hydrogenation and imination increased the hydrogen bond energy. Results also revealed that the chemical functionalization of DNA molecules exhibit a ferromagnetic ground state, reaching magnetization up to 4.665 μB and complex magnetic ordering. We further demonstrated that the functionalization could induce tautomerism (proton migration in the base pair systems). The present study provides a theoretical basis for understanding the functionalization further into DNA molecules and visualizing possible future applications.