bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cultural specialization as a double-edged sword: division into specialized guilds might promote cultural complexity at the cost of higher susceptibility to cultural loss
Authors: Ben-Oren Yotam , Kolodny Oren , Creanza Nicole 
Published: January 2023

The transition to specialization of knowledge within populations could have facilitated the accumulation of cultural complexity in humans. Specialization allows populations to increase their cultural repertoire without requiring that members of that population increase their individual capacity to accumulate knowledge. However, specialization also means that domain-specific knowledge can be concentrated in small subsets of the population, making it more susceptible to loss. Here, we use a model of cultural evolution to demonstrate that specialized populations can be more sensitive to stochastic loss of knowledge than populations without subdivision of knowledge, and that demographic and environmental changes have an amplified effect on populations with knowledge specialization. Finally, we suggest that specialization can be a double-edged sword; specialized populations may have an advantage in accumulating cultural traits but may also be less likely to expand and establish themselves successfully in new demes owing to the increased cultural loss that they experience during the population bottlenecks that often characterize such expansions.
This article is part of the theme issue ‘Human socio-cultural evolution in light of evolutionary transitions’.
A Novel Therapy for ALS: Allogeneic Schwann Cell Extracellular Vesicles
Authors: Goldschmidt-Clermont Pascal J. , Khan Aisha , Guest James D. , Jimsheleishvili George , Graham Patricia , Brooks Adriana , Silvera Risset , Goldschmidt Alexander J.P. , Pearse Damien D. , Dietrich W. Dalton , Brown Robert , Levi Allan D. 
Published: January 2023

SummaryAmyotrophic Lateral Sclerosis (ALS) is a terminal condition with accelerated loss of motor neurons (MN), resulting in the progressive paralysis of affected patients. ALS is either sporadic (90%) or genetically transmitted (10%) and affects cortical (pyramidal) and spinal cord (lower) MN, axons, and respective muscle endplates. ALS research has focused on MN survival, and current FDA-approved therapies provide only small patient survival benefits. This study reports the intravenous (IV) delivery of serial infusions of allogenic Schwann cell-derived extracellular vesicles (SCEV). The recipient had transient clinical stabilization during treatment but deteriorated rapidly during a pause in the infusions. There were no SCEV infusion-related adverse events observed. Allogeneic SCEV appeared safe for IV delivery in this case and may have therapeutic potential.
Clinical Testing of Pediatric Mpox Specimens: Unique Features and Challenges in a Low Prevalence Population
Authors: Ma Angela , Bradley Benjamin T. 
Published: January 2023

AbstractBACKGROUNDPediatric mpox cases comprise less than 0.3% of the total cases reported in the United States during the global 2022 outbreak. As a result, relatively little is known about the epidemiology or performance characteristics of clinical testing in this group.METHODSWe retrospectively extracted and analyzed results for pediatric mpox specimens tested at a national reference laboratory from July to December 2022.RESULTSDuring our study period 13.4% (2,063/15,385) of specimens were from individuals <18 years of age. The positivity rate of pediatric specimens was significantly lower than in adults (1.3% vs 22.3%). The pediatric cohort also consisted of a higher percentage of females (42.7% vs 31.0%) and lower percentage of specimens from genital sources (9.0% vs 19.7%) as compared to adults. In children, specimens were most frequently collected from 1-year-olds (10.1%) and least frequently from 11-year-olds (3.5%). Positivity rates were disproportionately elevated in the less than 1-year and 17-year-old age groups (7.8% and 6.4%, respectively). Ct values of positive cases were not statistically different between pediatric and adult cohorts (25.2 vs 22.2, p>0.05). When all pediatric cases with an initial positive mpox result were examined, 5/26 were classified as inconclusive and 2/26 were determined to be false positives. Based on these results, the positive predictive value of monkeypox virus detection was 90.5% (95% CI: 70.4-97.4%) in children.CONCLUSIONThese results highlight important differences between pediatric and adult mpox populations and reinforce the need for clinical correlation when reporting positive results from a low prevalence population.
Risk of Nephrolithiasis in adults heterozygous forSLC34A3Ser192Leu in an unselected health system cohort
Authors: Nwachukwu Chinedu , Singh Gurmukteshwar , Moore Bryn , Strande Natasha T , Bucaloiu Ion D , Chang Alexander R 
Published: January 2023

AbstractHomozygous or compound heterozygous mutations in solute carrier family 34, member 3 (SLC34A3) cause hereditary hypophosphatemic rickets with hypercalciuria (HHRH). Patients heterozygous forSLC34A3pathogenic variants may be at increased risk for renal calcification but reports have been mostly limited to family members of patients with autosomal recessive HHRH. To determine the phenotypic spectrum ofSLC34A3Ser192Leu, we examined the most pathogenicSLC34A3variant Ser192Leu (238 out of 174,417 participants) in an unselected, health system-based research cohort in central and northeast Pennsylvania.SLC34A3Ser192Leu heterozygotes had higher risks of nephrolithiasis ICD diagnosis (13% vs. 6%), hypophosphatemia <2.5 mg/dL (31/96 [32%] vs. 6226/39636 [16%]), lower eGFR (−4.43, 95% CI: −7.03, −1.83; p=0.001) and tended to have higher prevalence of kidney/liver cyst ICD codes (5% vs. 3%; p=0.09), compared to controls. Further studies are needed to determine whether personalized approaches (i.e. phosphate supplementation) to patients heterozygous forSLC34A3pathogenic variants can reduce kidney stone burden and risk of kidney function decline.
Waning Immunity Against XBB.1.5 Following Bivalent mRNA Boosters
Authors: Lasrado Ninaad , Collier Ai-ris Y. , Miller Jessica , Hachmann Nicole P. , Liu Jinyan , Sciacca Michaela , Wu Cindy , Anand Trisha , Bondzie Esther A. , Fisher Jana L. , Mazurek Camille R. , Patio Robert C. , Powers Olivia , Rodrigues Stefanie L. , Rowe Marjorie , Surve Nehalee , Ty Darren M. , Korber Bette , Barouch Dan H. 
Published: January 2023

AbstractThe SARS-CoV-2 Omicron variant has continued to evolve. XBB is a recombinant between two BA.2 sublineages, XBB.1 includes the G252V mutation, and XBB.1.5 includes the G252V and F486P mutations. XBB.1.5 has rapidly increased in frequency and has become the dominant virus in New England. The bivalent mRNA vaccine boosters have been shown to increase neutralizing antibody (NAb) titers to multiple variants, but the durability of these responses remains to be determined. We assessed humoral and cellular immune responses in 30 participants who received the bivalent mRNA boosters and performed assays at baseline prior to boosting, at week 3 after boosting, and at month 3 after boosting. Our data demonstrate that XBB.1.5 substantially escapes NAb responses but not T cell responses after bivalent mRNA boosting. NAb titers to XBB.1 and XBB.1.5 were similar, suggesting that the F486P mutation confers greater transmissibility but not increased immune escape. By month 3, NAb titers to XBB.1 and XBB.1.5 declined essentially to baseline levels prior to boosting, while NAb titers to other variants declined less strikingly.
Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen
Authors: Chen Grischa Y. , Thorup Natalia R. , Miller Abigail J. , Li Yao-Cheng , Ayres Janelle S. 
Published: January 2023

ABSTRACTAnimals have evolved two defense strategies to survive infections. Antagonistic strategies include mechanisms of immune resistance that operate to sense and kill invading pathogens. Cooperative or physiological defenses mediate host adaptation to the infected state, limiting physiological damage and disease, without killing the pathogen, and have been shown to cause asymptomatic carriage and transmission of lethal pathogens. Here we demonstrate that physiological defenses cooperate with the adaptive immune response to generate long-term asymptomatic carriage of the lethal enteric murine pathogen,Citrobacter rodentium. Asymptomatic carriage of genetically virulentC. rodentiumprovided immune resistance against subsequent infections. Host immune protection was dependent on systemic antibody responses and pathogen virulence behavior, rather than the recognition of specific virulent factor antigens. Finally, we demonstrate that an avirulent strain ofC. rodentiumin the field has background mutations in two genes that are important for LPS structure. Our work reveals novel insight into how asymptomatic infections can arise mechanistically with immune resistance, mediating exclusion of phenotypically virulent enteric pathogen to promote asymptomatic carriage.
Defective ribosome assembly impairs leukemia stem cell function in a murine model of acute myeloid leukemia
Authors: Sjövall Daniel , Ghosh Sudip , Hansson Jenny , Guibentif Carolina , Jaako Pekka 
Published: January 2023

ABSTRACTDespite the advanced understanding of disease mechanisms, the current therapeutic regimen fails to cure most patients with acute myeloid leukemia (AML). In the present study, we address the role of protein synthesis control in AML leukemia stem cell (LSC) function and leukemia propagation. We apply a murine model of mixed-lineage leukemia-rearranged AML to demonstrate that LSCs are characterized by high global protein synthesis rate. Using a genetic model that permits inducible and graded regulation of ribosomal subunit joining, we show that defective ribosome assembly leads to a significant survival advantage by selectively eradicating LSCs but not normal hematopoietic stem and progenitor cells. Finally, transcriptomic and proteomic analyses identify a rare subset of LSCs with immature stem cell signature and high ribosome content that promotes the resistance to defective ribosome assembly. Collectively, our study unveils a critical requirement of high protein synthesis rate for LSC function and highlights ribosome assembly as a therapeutic target in AML.
Bacteriophage therapy for the treatment ofMycobacterium tuberculosisinfections in humanized mice
Authors: Yang Fan , Labani-Motlagh Alireza , Moreira Josimar Dornelas , Ansari Danish , Bohorquez Jose Alejandro , Patel Sahil , Spagnolo Fabrizio , Florence Jon , Vankayalapati Abhinav , Vankayalapati Ramakrishna , Dennehy John J. , Samten Buka , Yi Guohua 
Published: January 2023

AbstractThe continuing emergence of new strains of antibiotic-resistant bacteria has renewed interest in phage therapy; however, there has been limited progress in applying phage therapy to multi-drug resistantMycobacterium tuberculosis(Mtb) infections. In this study, we tested three bacteriophage strains for theirMtb-killing activities and found that two of them efficiently lysedMtbH37Rv in 7H10 agar plates. However, only phage DS6A efficiently killed H37Rv in liquid culture and inMtb-infected human primary macrophages. In subsequent experiments, we infected humanized mice with aerosolized H37Rv, then treated these mice with DS6A intravenously to test itsin vivoefficacy. We found that DS6A treated mice showed increased body weight and improved pulmonary function relative to control mice. Furthermore, DS6A reducedMtbload in mouse organs with greater efficacy in the spleen. These results demonstrated the feasibility of developing phage therapy as an effective therapeutic againstMtbinfection.
Branding Creative Cities of Gastronomy: the role of brand experience and the influence of tourists' self-congruity and self-expansion
Authors: Guo YuLan , Hsu Fu Chieh 
Published: January 2023

PurposeThis study explores the brand management and marketing of Creative Cities of Gastronomy. A framework based on brand experience was constructed to investigate its relationship with tourists' brand attachment and brand identification. Two factors that enable tourists to have a stronger brand experience from the self-concept perspective – self-congruity and self-expansion – were also examined.Design/methodology/approachThe authors adopted a quantitative research design and collected data from participants who had visited Creative Cities of Gastronomy. A total of 515 valid questionnaires were collected online and offline. Partial least squares structural equation modeling (PLS-SEM) was used for data analysis and hypothesis testing.FindingsThe results showed that brand experience positively affects brand identification and attachment. The brand experience of tourists who considered themselves to be “foodies” was enhanced in the Creative Cities of Gastronomy through self-congruity. The results also confirmed that the relationship between self-congruity and brand experience is mediated by self-expansion.Originality/valueStudies on the Creative Cities of Gastronomy are limited. The few that have explored these cities are dominated by qualitative approaches. This study applied empirical data to examine the brand experience in Creative Cities of Gastronomy. The authors successfully verified that brand experience is effective for building positive relationships with brand attachment and identification. The study also confirmed that self-congruity and self-expansion are important antecedents of brand experience in Creative Cities of Gastronomy. This study enriches the literature by providing empirical evidence and insights into the marketing and branding of these cities.
Innovative food and sustainable consumption behaviour: the role of communication focus and consumer-related characteristics in lab-grown meat (LGM) consumption
Authors: Sestino Andrea , Rossi Marco Valerio , Giraldi Luca , Faggioni Francesca 
Published: January 2023

PurposeThe purpose of this paper is to investigate consumers' reactions to a new kind of green food product that is the so-called lab-grown meat (LGM). This kind of meat does not derive from animal or vegetal cultures but is produced on the basis of “tissue-engineering” technologies, by injecting muscle tissue from an animal into a cell culture, allowing cells to “grow” outside the animal's body. By considering the similar nutritional characteristics of traditional types of meat, and the potential in terms of sustainability, the authors investigate the effect of the advertising, communication focus promoting LGM-based meat, on consumers' willingness to buy (WTB) and word-of-mouth (WOM), by shedding light on the moderator role of consumers' environmentalism and status consumption orientation tendency in influencing such relationship.Design/methodology/approachThrough an exploratory research design, the authors conducted a study based on a two-cell experiment that manipulated the advertising communication focus by using a hamburger made of synthetic meat related to a fictitious brand called “Gnam”, to manipulate the advertising communication focus (sustainability vs. taste), then evaluating consumers' WTB, WOM, environmentalism and status consumption orientation.FindingsResults show that the communication focus (sustainability vs. taste) exerts a positive effect on consumers' WTB and WOM, and how such effect is magnified both by consumers' environmentalism and status consumption orientation, in the attempt to show other a green status and their green consumption tendency.Research limitations/implicationsDespite the promising results, the study does not consider other consumers' individual differences, i.e. as for the role of age, or cultural differences.Practical implicationsPractically, this study suggests marketers and managers how to design effective marketing campaigns to incentivise LGM-based food products purchase, and promote positive WOM, on the basis of certain consumers' individual differences useful to segment their clientele in terms of environmentalism, and status consumption orientation tendency.Social implicationsSocially, this study may contribute to incentivising the use of alternative forms of meat as a food product not deriving from animal or vegetal culture, coherently with recent sustainability worldwide claimed goals.Originality/valueThis is the first paper to investigate consumers' reactions to LGM-based food products, by shedding light on the fundamental role of consumers' individual differences.
Benchmarking bike-sharing systems: an analysis of the sustainable potential of use-oriented solutions
Authors: Inhof Aline Cervi , Cauchick-Miguel Paulo Augusto , Moro Suzana Regina , Zomer Thayla Tavares de Sousa 
Published: January 2023

PurposeProduct-service systems (PSS) are regarded as highly sustainable solutions. However, studies identifying and comparing the sustainable potential of product-service offerings by considering the three sustainability dimensions are still scarce. This paper aims to benchmark and analyse the sustainable potential of a use-oriented PSS, showing the influence of the context of implementation on the sustainable potential of the solutions.Design/methodology/approachBy adopting a competitive benchmarking approach, six bicycle-sharing systems from different countries were selected for analysis. The main sustainability-related aspects in use-oriented PSS (the systems investigated) were identified through a literature review. Multiple secondary sources were used to collect data about the analysed PSS. A qualitative analysis was conducted through triangulation of the sources to identify and compare the systems by considering the selected sustainability aspects.FindingsThe main results show that use-oriented PSS provide a range of economic, social, and environmental benefits, confirming the sustainable potential of such solutions. Several similarities between the systems have been identified, along with some differences, especially regarding their integration with other transport systems and the use of renewable energy, which can affect users' acceptance, operation efficacy, and overall sustainable potential of the solutions.Practical implicationsThis study identifies best practices that can be considered by other bike-sharing businesses to improve their sustainability potential.Originality/valueThis study identifies and explores the sustainable potential of bicycle-sharing solutions using a benchmark approach. It augments existing empirical knowledge on sustainable PSS and business models by revealing best practices, including the context that may enhance the sustainability potential of the solutions regarding environmental, economic, and social benefits.
Resistance to blockchain adoption in the foodservice industry: moderating roles of public pressures and climate change awareness
Authors: Jang Ha-Won , Yoo Joanne Jung-Eun , Cho Meehee 
Published: January 2023

Purpose
Blockchain technology has created possibilities for environmental supply chain sustainability and climate protection. However, because of its early development stage, users tend to resist the adoption of this new technology. The purpose of this study is to investigate the effects of resistance on blockchain adoption intentions in the context of the foodservice industry. This study further explores if public pressures and climate change awareness could possibly weaken the negative relationships between blockchain resistance and adoption intentions.

Design/methodology/approach
Data were collected from managers and full-time employees in the foodservice industry, using an online research panel survey. A structural equation model was developed and tested to examine the hypothesized relationships. Additionally, a multi-group analysis was performed to test the moderating roles of public pressures and climate change awareness.

Findings
The findings from this study confirmed that foodservice employees’ characteristics, including traditional barriers, and blockchain technology factors, like perceived risk, are both significant in forming resistance to blockchain. This study also demonstrated the significant roles of internal and external stakeholders in weakening the negative associations between blockchain resistance and adoption intentions.

Research limitations/implications
This study recommends that foodservice companies address how to reduce their employees’ negative perceptions about changes imposed by blockchain adoption. This study also suggests the joint consideration of the pressures from internal and external stakeholders to provide continued insights into developing environmental practices for the foodservice industry.

Originality/value
This study extends the theoretical underpinning of the innovation resistance theory by incorporating the stakeholder theory as a strong foundation for understanding how external pressures and internal awareness may influence foodservice employees’ responses to the implementation of blockchain technology to mitigate climate change.
Inter-state disparities in government health expenditure in India: a study of national rural health mission
Authors: Ud Din Mohammad Azhar , Dar Muzffar Hussain , Haseen Shaukat 
Published: January 2023

PurposeThe study aims to compare India's public health expenditure at the international and state levels. The paper also empirically examines the regional disparities in NRHM spending across the 21 selected states of India.Design/methodology/approachThe tools of absolute β-and σ-convergence are used in the analysis to test the regional convergence. The average annual growth rate across the states is the dependent variable for β-convergence, and time is the second dependent variable but is used for s-convergence. In contrast, the initial value of NRHM expenditure and the coefficient of variation of NRHM expenditure are used as independent variables, respectively. Descriptive statistics are also used for the study. The data are annual and cover the panel from 2007 to 2020.FindingsThe study attests to the hypothesis of β-and σ-convergence for the selected states in the period mentioned. The observed convergence in NRHM expenditure is due to the shift in the government's attention from the non-high focus high focus states to high states through the national rural health mission policy. The coefficient of variation across the states also shows a declining trend and provides the robustness of the σ-convergence.Originality/valueAs far as the literature is concerned, none of the existing studies examines the convergence of a public health expenditure scheme like the National Rural Health Mission across the Indian states by applying the techniques of β-and σ-convergence. The novelty of the study is using the newly updated dataset and validating the convergence hypotheses in the National Rural Health Mission expenditure case.