bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical outcomes in elderly patients with infections caused by NDM-producing Klebsiella pneumoniae. Results from a real-life retrospective single center study in an endemic area
Authors: Mura Maddalena , Longo Benedetta , Andreini Roberto , Sbrana Francesco , Ripoli Andrea , Andreoli Elisabetta , Sani Spartaco , Tumbarello Mario , Meini Simone 
Published: May 2023

Abstract
Real-life outcomes data for elderly patients with infections caused by Klebsiella pneumoniae producing New Delhi metallo-beta-lactamase (NDM-Kp) are lacking. We conducted a retrospective cohort study enrolling 33 consecutive adult patients (mean age 77.4 years; 48.5% males; mean Charlson Comorbidity Index-CCI 5.9) hospitalized for NDM-Kp infections during a 24 months period in an Italian highly endemic area. 78.8% were admitted to Internal Medicine ward. 45.4% of patients had bloodstream infections (BSI), 39.4% urinary tract infections (UTI) without BSI, 9.1% respiratory tract infections and 6.1% intra-abdominal infections. 93.9% had rectal colonization. Adequate definitive antibiotic therapy (mainly represented by aztreonam plus ceftazidime/avibactam) was provided to 36.4% of cases. Mean age and CCI of patients adequately treated were significantly lower than those inadequately treated (71.2 vs 80.9 years, p = 0.041, and 4.6 vs 6.7, p = 0.040, respectively). Patients adequately treated had a mean hospitalization length significantly higher (28 vs 15 days, p = 0.016). The overall 30 day-survival rate of patients adequately and inadequately treated was 83.3% and 57.1%, respectively: this difference was not statistically significant. Mean age and CCI of 22 patients who survived at 30 days were lower than those of 11 patients who died (73.7 vs 84.8 years, p = 0.003, and 5.3 vs 7.2, p = 0.049, respectively). Twelve survivors received an inadequate therapy: 8/12 had UTI. Six of 9 patients inadequately treated who died within 30 days, died before microbiological diagnosis. Our study provides real-life data on outcomes of elderly and multimorbid patients hospitalized for infections caused by NDM-Kp. Further studies with larger sample size are warranted.
Inhibition of DJ-1 degradation by TrkB promotes the progression and maintenance of traits of cancer stem cells in hepatocellular carcinoma
Authors: minsoo kim , Lee WonSung , Jin Wook 
Published: May 2023

Abstract
Although TrkB may be associated with the pathogenesis of various cancer by upregulation, how upregulation of TrkB led to tumor progression in hepatocellular carcinoma (HCC) and the signaling mechanisms by which TrkB induces motility, invasion, metastasis, drug resistance, and acquisition of self-renewal traits have remained unclear. Here, we demonstrated that TrkB was significantly upregulated in highly metastatic HCC cells and HCC patients. Also, increased TrkB levels were significantly correlated with tumor stages and poor survival of HCC patients. Furthermore, upregulated TrkB expression enhances the metastatic ability of HCC cells through reduced anoikis sensitivity, induced migration, colony formation. Most strikingly, TrkB markedly enhances the activation of STAT3 by preventing DJ-1 degradation through the formation of the TrkB/DJ-1 complex. This signaling mechanism is responsible for triggering cellular traits of highly aggressive HCC. The activation of the EMT program of HCC via increasing DJ-1 stability by TrkB induces the gain of cancer stem cell states and chemoresistance via the upregulation of stem cells cell markers and ABC transporters. Also, TrkB-mediated inhibition of DJ-1 degradation promotes tumor formation and metastasizes to other organs in vivo. Our observations illustrate that TrkB is a prognostic and therapeutic targeting in promoting aggressiveness and metastasis of HCC.
Design of Roll-Forming Process for U-Profile Rail
Authors: Kim Dongbum 
Published: May 2023

Abstract
Roll forming is a manufacturing process that involves plastic forming via bending using a rolling motion. During roll forming, a coil or blank is formed incrementally in a stepless and continuous process with the aid of rolls to fabricate profile rails. The shape of the rolls predicted the incremental deformation in the cross-sections of the U-profile rails. However, the final shape after the roll-forming process is entirely different from the modeled parts because of the springback caused by the mechanical properties of the materials. The design of roll-forming processes has been investigated to address typical plastic defects, such as springback and residual stress. Roll flower diagrams were developed in the initial stage of the design of the roll-forming processes. These diagrams show the cross-sectional shapes of the product at various stages of the process, superimposed on each other. The diagrams contain information for the process design, including the incremental deformation, number of passes, and setup angle of the rolls. There is no standard method for designing roll–flower diagrams. These were developed based on the designer’s experience with the material properties and multiple shapes. In this study, roll flower diagrams were designed using the developed formula, considering constant radius-of-curvature or length-of-curvature zones in the cross-sections of U-profile rails. Roll-forming processes were simulated using the commercial FEM code Abaqus to measure the loads of the rolls, springback of the blank, and residual-stress history. Simulation and experimental results regarding the shapes of the U-profile rails were compared to validate the process design method.
USP11 deubiquitinates E-cadherin and maintains luminal fate of mammary cells to suppress breast cancer
Authors: Qian Tao , Bai Feng , Zhang Shiwen , Xu Yuping , Wang Yuchan , Yuan Shuping , Liu Xiong , Du Yaru , Peng Bin , Zhu Wei-Guo , Xu Xingzhi , Pei Xin-Hai 
Published: May 2023

Abstract
Background: Basal-like breast cancer may originate from luminal epithelial or cancerous cells. Inadequately repaired DNA damage impairs luminal differentiation and promotes aberrant luminal to basal trans-differentiation in mammary epithelial cells. USP11, a deubiquitinase, plays a critical role in DNA damage repair. The role of USP11 in controlling mammary cell differentiation and tumorigenesis remains poorly understood.
Methods: We generated Usp11 knock-out mice and breast cancer cell lines expressing wild type and mutant form of USP11. By using these mutant mice, cell lines, and human USP11 deficient and proficient breast cancer tissues, we tested how USP11 controls mammary cell fate.
Results: We generated Usp11 knock-out mice and found that deletion of Usp11 impaired luminal differentiation and promoted DNA damage in mammary epithelial cells. Over-expression of wild-type (WT) USP11, not a deubiquitinase-inactive mutant form of USP11, promoted luminal and epithelial differentiation, enhanced DNA damage repair, and suppressed tumorigenesis in mice. Mechanistically, we found that Usp11 enhanced the protein expression of E-cadherin dependent on its deubiquitinase activity. We discovered that USP11 bound to E-cadherin through its C-terminal region, and that USP11 was a deubiquitinase of E-cadherin. In human breast cancers, expression of USP11 was positively correlated with that of E-cadherin and high USP11 predicted a better recurrence-free survival.
Conclusions: Our findings provide compelling genetic and biochemical evidence that USP11 not only promotes DNA damage repair, but also deubiquitinates E-cadherin and maintains the luminal feature of mammary epithelial and cancerous cells, to suppress breast cancer.
Pioneering Experimental Exploration of an in-situ Characterization of the Shearing Stress-Strain Mechanism of Human Plantar Soft Tissue
Authors: Wu Longyan , Tang Lisheng , Zhu Jun , Geng Xiang , Jiang Xilin , Ma Xin , Huang Ran 
Published: May 2023

Abstract
Aiming to characterize the material mechanism of biological soft tissue, which is intensively studied in biomechanics, however the in-situ method is very difficult whereas the sample preparation from living body for classical tests is almost impossible, we have designed and manufactured a dynamic mechanical analysis (DMA)-like device to achieve the in-situ and in-vivo stress-strain test for living plantar tissue. A series of pioneering tests of horizontal shearing on the heel of five volunteers are reported, with the reference of tests on mimic foot model made by silicon rubber, standard silicon rubber brick sample, and finite elementary analysis. Beside certifying the device and method are practical, interesting phenomena are observed implying great potentials of the invention in future research.
Constraining the parent magma composition of the mineralized deep Flatreef at Turfspruit, northern lobe, Bushveld Complex: insights from silicate mineral compositions
Authors: Chaumba Jeff B. , Prevec Stephen A. , Dyan Siyasanga 
Published: May 2023

Abstract
Unlike platinum-group elements (PGEs) deposits from the western and eastern lobes of the Bushveld Complex which are generally thought to have been largely formed as a consequence of primary magmatic processes, PGEs from the northern lobe are generally thought to have originated by processes involving contamination of parental magmas by crustal sources. We investigated mineral compositions from the deep Flatreef at the Turfspruit farm where dolomitic calc-silicate rocks form part of the country rocks to determine the role of crustal sources in the formation of PGE mineralization. Orthopyroxene compositions vary widely from En77.9 to En91.7, and compositions of clinopyroxene display wider variations (Ca38.8−67.0Mg24.7−51.6Fe6.4−19.6). Plagioclase similarly varies widely in composition (An1.3−73.7) whereas compositions of olivine (Fo85.9−87.6) are very restricted. Temperatures ranging from ~ 500 to 1300 oC were obtained from two pyroxene geothermometers similarly likely indicating crystallization from contaminated magma and/or hydrothermal alteration. The wide compositional ranges of calcium-bearing phases such as clinopyroxene and feldspars suggest that the Platreef crystallized from parental magmas that were contaminated by dolomitic calc-silicate floor rocks. The very restricted and highly magnesian forsterite contents in olivines are inconsistent with expected primary magmatic compositions. Simple mixing models utilizing existing sulfur isotope data suggest that, in the Turfspruit area, contamination of Bushveld Complex parental magmas with 2–10% contamination by floor rock dolomitic calc-silicates with δ34S values of 32‰ would account for the observed data in the Turfspruit area.
A Parallel Design of Frequent Item-sets Mining on CPU-MIC Heterogeneous Systems
Authors: Zhang Bin , Dong Wenyong , Zhao Chao , Luo Meizhen , Wu Liangshun , Yang Shujun , Hu Juan , Peng Ling , Yan Shankai 
Published: May 2023

Abstract
With the rapid growth of the text mining technology, knowledge discovery in text is appealing more and more to researchers. Furthermore, association rule mining (ARM), an essential issue in data mining, is widely used in the field of text information. However, due to the exploding amount of information in different fields, the serial ARM algorithm has left much to be desired. In this paper, we propose a new parallel ARM algorithm on corpus, using MPI programming interface. The algorithm mainly makes use of distributed inverted hash index, a communication pattern based on chessboard decomposition and a multi-thread candidate item-set filtering method running on MIC platform to accelerate the generation of frequent item sets. We implemented the algorithm and run some test on the supercomputer cluster. The performance evaluations show that the speedup rate can reach 34 when using 7 nodes.
An Empirical Study to Trace the Impact of Macro- Economic Variables and Information Asymmetry on the Aum of Indian Mutual Funds- a Vecm and E- Garch Model Approach
Authors: kulshreshtha Priyank 
Published: May 2023

Abstract
Early theories of finance discarded the role of human behaviour in decision making, but over a period it is realised that human emotions play pivotal role in investors’ choice. Investors’ behaviour gets affected by so many factors namely personal factors, demographic factors, geographic factors, regulatory factors, macro- economic factors etc. Amongst these factors, macro- economic factors play a direct and important role in investment decision making because these factors impact entire system. In this study the impact of macro- economic variables is tracked on the investors’ behaviour towards mutual funds by taking Assets Under Management (AUM) as a proxy of for investor behaviour. Further, this study attempts to trace the impact of bad news on the investor behaviour. For accomplishing the objectives Vector Error Correction Model and E- GARCH model is used. It is found that 6 identified macro- economic variables explain 48% variation in the AUM and the error correction term is not statistically significant and it is also found that leverage effect exists in AUM which means that bad news impacts the volatility of AUM more than good news.
A lightweight high-resolution Human pose estimation method with an integrated attention mechanism
Authors: Liu Fuchen , Zhou Sijia , Wang Xiaocui , Zhang Dezhou 
Published: May 2023

Abstract
Deep learning has significant advantages in the field of human posture estimation. However, traditional methods often increase the parameter size and complexity of posture estimation networks by widening and deepening them to improve performance. To address this issue, this paper proposes a lightweight human posture estimation network, ADNet, based on the high-resolution network(HRNet). ADNet replaces Basic Blocks and downsampling in the high-resolution network with GABlocks and GDBlocks that incorporate lightweight convolution and attention mechanisms to reduce the number of parameters and computational complexity in the network. Additionally, ADNet solves the problem of feature redundancy by fusing relationships between different channels to make effective feature channels fully utilized. Experimental results show that ADNet achieves high-precision detection of human keypoint information even with fewer parameters and less computational complexity than commonly used human posture estimation networks, such as Cascaded Pyramid Network (CPN), Stacked Hourglass Network(Hourglass), and HRNet. Results also indicate that, compared to HRNet, ADNet reduces the model parameter size by 69.1% and computational complexity by 58.9% under the same image resolution and environment configuration. Furthermore, in the visualization of feature maps, the network using ADNet exhibits stronger feature extraction performance and less feature redundancy.
Floral resources, energetic value and pesticide residues in larval provisions collected by Osmia bicornis in oilseed rape dominated landscape
Authors: Misiewicz Anna , Mikołajczyk Łukasz , Bednarska Agnieszka J. 
Published: May 2023

Abstract
Pollinators in agricultural landscapes are facing global decline and the main pressures include food scarcity and pesticide usage. Although intensive agricultural landscapes are poor habitats for wild pollinators, the mass flowering crops may provide important food resources, albeit monofloral and short-term, which in addition may contain pesticide residues. We explored how the landscape composition with a different proportion of oilseed rape (6%-65%) around Osmia bicornis nests affects floral diversity, contamination with pesticides, and energetic value of provisions collected by bees as food for their offspring. The bees collected pollen from 28 floral taxa (6-15 per nest) and provisions were dominated by Brassica napus (6.0-54.2%), Quercus (1.2-19.4%) and Ranunculus (0.4-42.7%) found in all 12 nests, but also by Poaceae (1.2-59.9%, 11 nests) and Acer (0.6-42%, 8 nests). Residues of 12 pesticides were found in provisions, with acetamiprid, azoxystrobine, boscalid, and dimethoate being the most frequently detected at concentrations up to 1.2, 198.4, 16.9 and 17.8 ng/g, respectively. Floral diversity and energetic value of provisions, but not the Pesticide Risk Index depended on landscape structure. Moreover, pollen diversity decreased, and energetic value increased with landscape diversity. Thus, even a structurally simple landscape may provide diverse food for O. bicornis if the nest is located close to a single but resource-diverse patch. Both B. napus and non-crop pollen were correlated with pesticide concentrations.
Volume of the proximal half of the thoracic aorta is the most comprehensive FDG-PET/CT indicator of arterial aging throughout adulthood
Authors: HURSTEL Moira , JOLY Laure , IMBERT Laetitia , ZIMMERMANN Gaetan , ROCH Véronique , SCHOEPFER Pauline , LAMIRAL Zohra , SALVI Paolo , BENETOS Athanase , VERGER Antoine , Marie Pierre Yves 
Published: May 2023

Abstract
Introduction
18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and computed tomography (CT) features of the proximal and more elastic half of the thoracic aorta are known to correlate with aorta stiffness in older populations. This prospective study aimed to analyze the changes in these FDG-PET/CT features between young, middle-aged, and older adults, and investigate associations with arterial stiffness and blood pressure (BP).
Methods
Young (< 40 years), middle-aged (40-to-60 years), and older (> 60 years) adults, who underwent an FDG-PET/CT, were prospectively recruited. FDG-PET/CT features of the proximal half of the thoracic aorta were analyzed relative to the age categories, BP and carotid-femoral pulse wave velocity (PWV), a reference indicator of aorta stiffness.
Results
We included 79 patients (38 women; 22 young, 19 middle-aged, and 38 older adults). An increase in age category was associated with increases in mean standardized uptake values (SUVs) of blood and aorta and most significantly in aorta SUV heterogeneity, represented by SUV standard deviation (SUV-SD), aorta calcification volume, and the aorta volume indexed to body surface area. However, this indexed aorta volume was the sole variable: (i) exhibiting a stepwise increase from young (median: 25 cm3/m2 [interquartile range: 20–28 cm3/m2]), to middle-aged (41 [30–48] cm3/m2, p < 0.001 vs. Young), and older (62 [44–70] cm3/m2, p < 0.001 vs. middle-age) adults, and (ii) selected in the multivariate predictions of systolic, diastolic, and pulse BP. Indexed aorta volume was also a multivariate predictor of PWV but in association with SUV-SD and hypertension.
Conclusion
In a population of patients referred to an FDG-PET/CT investigation, the indexed volume of the proximal and more elastic half of the thoracic aorta is the most comprehensive indicator of arterial aging. This imaging parameter exhibits a stepwise increase from young to middle-aged and older adults, is strongly linked to inter-individual changes in both arterial stiffness and BP, and thus, could help assess the early phases of arterial aging.
Trial registration
ClinicalTrial.gov, NCT03345290. Registered 17 November 2017, https://clinicaltrials.gov/ct2/show/NCT03345290?term=NCT03345290&draw=2&rank=1
Habitat Preference and Local Climate Influencing Mantella Baroni Activity and Abundance
Authors: Rasoarimanana Tantely , Edmonds Devin , Marquis Olivier 
Published: May 2023

Abstract
Amphibian habitat preferences have ecological, evolutionary, and conservation implications, but for most species we have no information about habitat use, especially at the microhabitat level. Relatedly, considering ongoing widespread amphibian population declines, baseline estimates of abundance are increasingly important for informing conservation, yet for most species we have no knowledge of their population sizes. We explored the habitat preferences and estimated abundance for the poison frog Mantella baroni in Vohimana Reserve, eastern Madagascar. We recorded microhabitat and environmental variables in 155 quadrats in forest valleys, on slopes, and on ridgelines, surveying both during the rainy season and at the onset of winter. Using occupancy models, we identified leaf litter depth and the number of small trees in a quadrat as the most important habitat features. Deeper litter and fewer small trees increased the probability of quadrat use. Mean 24-hr temperature influenced activity, with higher detection at warmer temperatures. Capture-recapture models estimated the two M. baroni populations in the reserve at 27 (95% CI: 22–49) and 197 (95% CI: 168–246) adult individuals. Our results provide the first information about habitat use for M. baroni, showing frogs select relatively open areas with deep litter near valley streams, likely due to the species eco-physiological requirements and reproductive behavior. Considering M. baroni is harvested commercially for the international pet trade, we note current export numbers could impact local populations if collection is not spread across multiple sites and we point to how our results can inform ex situ conservation efforts.
Visible-light photocatalysed Synthesis of Bioactive Benzo[b]thiophenes via Intramolecular C−S Bond Formation
Authors: Mishra Mangla , Srivast Vishal , Tivari Shraddha , Singh Praveen P. 
Published: May 2023

Abstract
Visible light driven synthesis of substituted benzo[b]thiophenes from phenylethenethiol under an air atmosphere at room temperature is reported, using eosin Y as an organophotoredox catalyst by intramolecular C−S bond formation. This process accepts a wide range of functional groups tolerance and generates benzo[b]thiophenes under highly environmentally benign conditions via transition-metal-free organic photoredox catalysis.
Nuclear structure, periodicity, and reactions of stable nuclei through 36Ar from average quark positions
Authors: Walsh Ray 
Published: May 2023

Abstract
Exact quark positions are indiscernible per the uncertainty principle. The hypothesis that quarks occupy average positions, however, leads to a variety of accurate predictions. Proposed average quark model (AQM) radius predictions correlate near-perfectly with accepted charge radii of stable nuclides through 36Ar. Per the model, alternating up- and down-quarks occupy average positions within linear and polygonal chains, and the distance between sequential quarks equals the proton’s radius. Best-fit solutions form anisotropic cylindrical lattices of stacked 6-nucleon (18-quark) rings. Evolving structures contain unique sub-structures that recur periodically every 12 nuclides, as presented within a periodic table of nuclear structures. Structural periodicity begins at 6Li and has led to the discovery of corresponding periodicities in nuclear magnetic moments and nucleosynthesis. The 12-nuclide periodicity of each is superior when analyzed against hypothetical 6,8,10,14, and 16-nuclide periodicities. Proposed quark structures are consistent with theoretical prolate hadron shapes, and open ring and cylindrical structures are consistent with electron scattering experiments demonstrating central depressions in the nuclide charge densities. A novel criterion of nuclear stability is presented: Nuclides containing contiguous alternating quark sequences tend to be stable, and tend to produce alternating nucleon sequences that contain stable equal ratios of neutrons to protons. Nuclides having disrupted quark sequences tend to be unstable, and tend to have unstable neutron/proton ratios. Model-consistent structures of 5He, 8Be, 18F, and 30P illuminate why they are unstable. The list of stable nuclides through 36Ar evolves one nucleon at a time. During nucleosynthesis, the AQM nuclide structure acts as a substrate that sterically selects whether a proton or neutron will be the next added nucleon, analogous to base pair selection in DNA replication. This method correctly predicts the most abundant isotope of every stable nuclide through 36Ar. The proposed model of nucleosynthesis exhibits important similarities to linear step-growth polymerization (SGP). Implications for the European Muon Collaboration effect are discussed.