bluuebunny/crossref_metadata_2025_split huggingface dataset:
A label-free fluorescent biosensor based on specific aptamer-templated silver nanoclusters for the detection of tetracycline
Authors: Yang Si , Li Chenxi , Zhan Hongyan , Liu Rong , Chen Wenliang , Wang Xiaoli , Xu Kexin 
Published: January 2023

AbstractTetracycline (TET) is a broad-spectrum antibiotic commonly used in the treatment of animals. TET residues in food inevitably threaten human health. High-performance analytical techniques for TET detection are required in food quality assessment. The objective of this study was to establish a label-free fluorescent biosensor for TET detection using specific aptamer-templated silver nanoclusters (AgNCs). An aptamer with a high specific binding ability to TET was used to synthesize a novel DNA-templated AgNCs (DNA-AgNCs). When TET is present, the aptamer’s conformation switched from an antiparallel G-quadruplex to a hairpin structure, altering the connection between AgNCs and the aptamer. Following the transformation of AgNCs into large sized silver nanoparticles (AgNPs), a fluorescence decrease was detected. When used to detect TET in milk, the proposed biosensor displayed high sensitivity and selectivity, with a limit of detection of 11.46 ng/mL, a linear range of 20 ng/mL−10 g/mL, and good recoveries of 97.7–114.6% under optimized conditions. These results demonstrate that the proposed biosensor was successfully used to determine TET quantitatively in food samples, suggesting that our method provides an efficient and novel reference for detecting antibiotics in food while expanding the application of DNA-AgNCs in related fields.
Use of KIDSCREEN health-related quality of life instruments in the general population of children and adolescents: a scoping review
Authors: Befus Eva-Grethe , Helseth Sølvi , Mølland Eirin , Westergren Thomas , Fegran Liv , Haraldstad Kristin 
Published: January 2023

Abstract
Purpose
Subjectively assessing health related quality of life (HRQoL) in children and adolescents is increasingly important in the public health field. One valid and widely used generic HRQoL instrument is the KIDSCREEN questionnaire. The aim of this study was to map all studies using KIDSCREEN instruments in the general population of children and adolescents aged 6–18 years.

Methods
A scoping review was conducted. The search strategy was formulated according to the Preferred Reporting Items for Systematic Reviews and Scoping Reviews guidelines. The databases Cinahl, socINDEX, Medline, Embase, APA Psychinfo, Scopus, and Eric were searched in October 2021.

Results
In total, 1365 papers were eligible for screening, 1031 were excluded and 334 reports were read in full. 252 reports were included. KIDSCREEN studies in the general population was predominantly conducted in Europe (n = 211). Most studies (n = 179) had a cross sectional design, while few experimental studies (n = 24) were found. The three KIDSCREEN versions comprising of 10, 27 and 52 items, were equally distributed between studies. The self-reported version (n = 225) of the KIDSCREEN instrument was more prevalent than the proxy version, while few studies discussed a cut point. Study contexts reflected international trends of public health challenges, commonly including mental- and psychosocial health, physical activity, socioeconomic status, and obesity.

Conclusion
KIDSCREEN is widely used in cross sectional studies assessing common public health challenges. Experimental and longitudinal assessments, possibly including relevant cut offs remain mainly unexplored and are recommended for future research.
The influence of resection margin width in patients with intrahepatic cholangiocarcinoma: a meta-analysis
Authors: Dai Yu-Shi , Hu Hai-Jie , Lv Tian-run , Hu Ya-Fei , Zou Rui-Qi , Li Fu-Yu 
Published: January 2023

Abstract
Background
Some studies have pointed out that a wide resection margin can improve the prognosis of intrahepatic cholangiocarcinoma, but some researchers disagree and believe that a wide margin may increase complications. The optimal margin length of intrahepatic cholangiocarcinoma is controversial.

Method
The literature was searched in PubMed, MedLine, Embase, the Cochrane Library, and Web of Science until December 31, 2021, to evaluate the postoperative outcomes of patients with different margin width after resection. Odds ratios (ORs) with 95% confidence intervals were used to determine the effect size.

Result
A total of 11 articles were included in this meta-analysis, including 3007 patients. The narrow group had significantly lower 1-, 3-, and 5-year overall survival rates and recurrence-free survival rates than the wide group. Postoperative morbidity and prognostic factors were also evaluated.

Conclusion
A resection margin width of over 10 mm is recommended in intrahepatic cholangiocarcinoma patients, especially in patients with negative lymph node and early tumor stage. When the resection margin width cannot be greater than 10 mm, we should ensure that the resection margin width is greater than 5 mm.
Tanshinone IIA ameliorates Aβ transendothelial transportation through SIRT1-mediated endoplasmic reticulum stress
Authors: Wan Can , Liu Xiao-Qi , Chen Mei , Ma Hui-Han , Wu Guang-Liang , Qiao Li-Jun , Cai Ye-Feng , Zhang Shi-Jie 
Published: January 2023

Abstract
Background
The disruption of blood-brain barrier (BBB), predominantly made up by brain microvascular endothelial cells (BMECs), is one of the characteristics of Alzheimer’s disease (AD). Thus, improving BMEC function may be beneficial for AD treatment. Tanshinone IIA (Tan IIA) has been proved to ameliorate the cognitive dysfunction of AD. Herein, we explored how Tan IIA affected the function of BMECs in AD.

Methods
Aβ1–42-treated brain-derived endothelium cells.3 (bEnd.3 cells) was employed for in vitro experiments. And we performed molecular docking and qPCR to determine the targeting molecule of Tan IIA on Sirtuins family. The APPswe/PSdE9 (APP/PS1) mice were applied to perform the in vivo experiments. Following the behavioral tests, protein expression was determined through western blot and immunofluorescence. The activities of oxidative stress-related enzymes were analyzed by biochemically kits. Nissl staining and thioflavin T staining were conducted to reflect the neurodegeneration and Aβ deposition respectively.

Results
Molecular docking and qPCR results showed that Tan IIA mainly acted on Sirtuin1 (SIRT1) in Sirtuins family. The inhibitor of SIRT1 (EX527) was employed to further substantiate that Tan IIA could attenuate SIRT1-mediated endoplasmic reticulum stress (ER stress) in BMECs. Behavioral tests suggested that Tan IIA could improve the cognitive deficits in APP/PS1 mice. Tan IIA administration increased SIRT1 expression and alleviated ER stress in APP/PS1 mice. In addition, LRP1 expression was increased and RAGE expression was decreased after Tan IIA administration in both animals and cells.

Conclusion
Tan IIA could promote Aβ transportation by alleviating SIRT1-mediated ER stress in BMECs, which ameliorated cognitive deficits in APP/PS1 mice.
The poorly understood yet potent risk of pulmonary artery thrombosis in-situ in Post-Acute COVID-19 syndrome
Authors: Payus Alvin Oliver , Lin Constance Liew Sat , Ibrahim Azliza 
Published: January 2023

AbstractPulmonary artery thrombosis in-situ is a term used to describe a pulmonary embolism occurs in the absence of deep vein thrombosis in the lower extremities. Most cases occur in a patient who had a recent traumatic injury to the chest. Other risk factors include the presence of hypercoagulable conditions, including inflammatory state, hypoxia and vascular endothelial injury. Although it has been discussed extensively in the acute COVID-19 disease, pulmonary artery thrombosis in-situ that occur in the setting of Post-Acute COVID-19 syndrome is not commonly reported and poorly understood.
Long COVID-19/post-COVID condition in children: do we all speak the same language?
Authors: Garazzino Silvia , Denina Marco , Pruccoli Giulia , Funiciello Elisa , Ramenghi Ugo , Fagioli Franca 
Published: January 2023

AbstractPost-COVID condition is a new and highly debated entity that is still to be outlined in its complexity, especially in the pediatric population. In response to the article by Trapani and colleagues, we report the results of a long-term follow-up conducted in the outpatient clinic of the Pediatric Infectious Diseases Unit on children admitted to our hospital with SARS-CoV-2 infection.
An updated “norepinephrine equivalent” score in intensive care as a marker of shock severity
Authors: Kotani Yuki , Di Gioia Annamaria , Landoni Giovanni , Belletti Alessandro , Khanna Ashish K. 
Published: January 2023

AbstractVasopressors and fluids are the cornerstones for the treatment of shock. The current international guidelines on shock recommend norepinephrine as the first-line vasopressor and vasopressin as the second-line vasopressor. In clinical practice, due to drug availability, local practice variations, special settings, and ongoing research, several alternative vasoconstrictors and adjuncts are used in the absence of precise equivalent doses. Norepinephrine equivalence (NEE) is frequently used in clinical trials to overcome this heterogeneity and describe vasopressor support in a standardized manner. NEE quantifies the total amount of vasopressors, considering the potency of each such agent, which typically includes catecholamines, derivatives, and vasopressin. Intensive care studies use NEE as an eligibility criterion and also an outcome measure. On the other hand, NEE has several pitfalls which clinicians should know, important the lack of conversion of novel vasopressors such as angiotensin II and also adjuncts such as methylene blue, including a lack of high-quality data to support the equation and validate its predictive performance in all types of critical care practice. This review describes the history of NEE and suggests an updated formula incorporating novel vasopressors and adjuncts.
Sound event triage: detecting sound events considering priority of classes
Authors: Tonami Noriyuki , Imoto Keisuke 
Published: January 2023

AbstractWe propose a new task for sound event detection (SED): sound event triage (SET). The goal of SET is to detect an arbitrary number of high-priority event classes while allowing misdetections of low-priority event classes where the priority is given for each event class. In conventional methods of SED for targeting a specific sound event class, it is only possible to give priority to a single event class. Moreover, the level of priority is not adjustable, i.e, the conventional methods can use only types of target event class such as one-hot vector, as inputs. To flexibly control much information on the target event, the proposed SET exploits not only types of target sound but also the extent to which each target sound is detected with priority. To implement the detection of events with priority, we propose class-weighted training, in which loss functions and the network are stochastically weighted by the priority parameter of each class. As this is the first paper on SET, we particularly introduce an implementation of single target SET, which is a subtask of SET. The results of the experiments using the URBAN–SED dataset show that the proposed method of single target SET outperforms the conventional SED method by 8.70, 6.66, and 6.09 percentage points for “air_conditioner,” “car_horn,” and “street_music,” respectively, in terms of the intersection-based F-score. For the average score of classes, the proposed methods increase the intersection-based F-score by up to 3.37 percentage points compared with the conventional SED and other target-class-conditioned models.
A systematic review of real-time detection and classification of power quality disturbances
Authors: Caicedo Joaquín E. , Agudelo-Martínez Daniel , Rivas-Trujillo Edwin , Meyer Jan 
Published: January 2023

AbstractThis paper offers a systematic literature review of real-time detection and classification of Power Quality Disturbances (PQDs). A particular focus is given to voltage sags and notches, as voltage sags cause huge economic losses while research on voltage notches is still very incipient. A systematic method based on scientometrics, text similarity and the analytic hierarchy process is proposed to structure the review and select the most relevant literature. A bibliometric analysis is then performed on the bibliographic data of the literature to identify relevant statistics such as the evolution of publications over time, top publishing countries, and the distribution by relevant topics. A set of articles is subsequently selected to be critically analyzed. The critical review is structured in steps for real-time detection and classification of PQDs, namely, input data preparation, preprocessing, transformation, feature extraction, feature selection, detection, classification, and characterization. Aspects associated with the type of disturbance(s) addressed in the literature are also explored throughout the review, including the perspectives of those studies aimed at multiple PQDs, or specifically focused on voltage sags or voltage notches. The real-time performance of the reviewed tools is also examined. Finally, unsolved issues are discussed, and prospects are highlighted.
Perceived ethnic discrimination, suicidal ideation and mastery in a multi-ethnic cohort: the HELIUS study
Authors: Willemen Fabienne E. M. , Heuschen Caroline B. B. C. M. , Zantvoord Jasper B. , Galenkamp Henrike , de Wit Matty A. S. , Zwinderman Aeilko H. , Denys Damiaan A. J. P. , Bockting Claudi L. H. , Stronks Karien , Lok Anja 
Published: January 2023

Background
The association between perceived ethnic discrimination (PED) and mental health conditions is well studied. However, less is known about the association between PED and suicidal ideation, or the role of positive psychosocial factors in this association.

Aims
To examine the association between PED and suicidal ideation among ethnic minority groups in Amsterdam, The Netherlands, and investigate whether ethnicity and mastery (people's extent of feeling in control of their lives and environment) moderate this association.

Method
Cross-sectional data from the multi-ethnic HELIUS study were analysed (n = 17 053) for participants of South-Asian Surinamese, African Surinamese, Ghanaian, Turkish and Moroccan origin. PED was measured using the Everyday Discrimination Scale, suicidal ideation using item 9 of the Patient Health Questionnaire-9 and mastery using the Pearlin–Schooler Mastery Scale.

Results
Logistic regression analyses demonstrated a small positive association between PED and suicidal ideation (OR = 1.068, 95% CI 1.059–1.077), which did not differ among ethnic minority groups. Mastery did not moderate the association between PED and suicidal ideation among the ethnic minority groups.

Conclusions
Our findings support the hypothesis that PED is associated with suicidal ideation and this association does not significantly vary between ethnic minority groups. Although higher levels of mastery were associated with lower suicidal ideation, mastery did not moderate the relationship between PED and suicidal ideation. Besides targeting ethnic discrimination as a societal problem, future longitudinal research is needed to investigate whether interventions aimed at improving mastery could reduce suicidal ideation in ethnic minority groups.
Reimagining Classroom Participation in the Era of Disability Justice and COVID-19
Authors: Mullaney Clare 
Published: January 2023

AbstractThis essay argues that the emphasis on spoken contributions in English and other humanities courses can exclude disabled students. The COVID-19 pandemic's necessitation of online learning has forced instructors to offer students multiple entry points for conversation—not only through spoken dialogue but also text threads, anonymous polls, and communal annotation assignments. Instructors’ shifts in participation guidelines both before and at the height of the pandemic reveal faculty members’ adoption of a disability justice pedagogy that privileges flexibility. Drawing on these transformations, the author offers pragmatic suggestions for how to value course contributions beyond students’ capacity to voice their reflections aloud. The relinquishment of rigid academic expectations for participation makes space not just for students with disabilities but also for other minority populations, including women students, nonbinary students, first-generation students, and students of color who contribute their expertise in more capacious ways than the standard, discussion-based classroom allows. To conclude, the author considers how instructors might replicate accessible online tools—from Zoom chats to asynchronous platforms—in the return to face-to-face teaching. These new and primarily virtual forms of engagement reframe participation not as individual contributions to conversation, but as ongoing work intended for the purpose of community growth and collective care.
Health system responsiveness to the mental health needs of Syrian refugees: mixed-methods rapid appraisals in eight host countries in Europe and the Middle East
Authors: Woodward Aniek , Fuhr Daniela C. , Barry Alexandra S. , Balabanova Dina , Sondorp Egbert , Dieleman Marjolein A. , Pratley Pierre , Schoenberger Samantha F. , McKee Martin , Ilkkursun Zeynep , Acarturk Ceren , Burchert Sebastian , Knaevelsrud Christine , Brown Felicity L. , Steen Frederik , Spaaij Julia , Morina Naser , de Graaff Anne M. , Sijbrandij Marit , Cuijpers Pim , Roberts Bayard ,   STRENGTHS consortium
Published: January 2023

Background: Syrian refugees have a high burden of mental health symptoms and face challenges in accessing mental health and psychosocial support (MHPSS). This study assesses health system responsiveness (HSR) to the MHPSS needs of Syrian refugees, comparing countries in Europe and the Middle East to inform recommendations for strengthening MHPSS systems. Methods: A mixed-methods rapid appraisal methodology guided by an adapted WHO Health System Framework was used to assess HSR in eight countries (Egypt, Germany, Jordan, Lebanon, Netherlands, Sweden, Switzerland, and Türkiye). Quantitative and qualitative analysis of primary and secondary data was used. Data collection and analysis were performed iteratively by multiple researchers. Country reports were used for comparative analysis and synthesis. Results: We found numerous constraints in HSR: i) Too few appropriate mental health providers and services; ii) Travel-related barriers impeding access to services, widening rural-urban inequalities in the distribution of mental health workers; iii) Cultural, language, and knowledge-related barriers to timely care likely caused by insufficient numbers of culturally sensitive providers, costs of professional interpreters, somatic presentations of distress by Syrian refugees, limited mental health awareness, and stigma associated to mental illness; iv) High out-of-pocket costs for psychological treatment and transportation to services reducing affordability, particularly in middle-income countries; v) Long waiting times for specialist mental health services; vi) Information gaps on the mental health needs of refugees and responsiveness of MHPSS systems in all countries. Six recommendations are provided. Conclusions: All eight host countries struggle to provide responsive MHPSS to Syrian refugees. Strengthening the mental health workforce (in terms of quantity, quality, diversity, and distribution) is urgently needed to enable Syrian refugees to receive culturally appropriate and timely care and improve mental health outcomes. Increased financial investment in mental health and improved health information systems are crucial.
Partial Vertical Ownership, Capacity Investment, and Information Exchange in a Supply Chain
Authors: Avinadav Tal , Shamir Noam 
Published: January 2023

Partial vertical ownership describes a situation in which a firm holds financial shares in either its supplier (referred to as partial backward integration) or its customer (partial forward integration). We study the effect of such financial interconnectedness on two operational decisions: capacity investment and information exchange. In our model, a retailer, who has superior information about the future market demand, has passive financial holdings in the supplier. Although this passive financial investment does not enable the retailer to directly influence the supplier’s operational decisions, it does affect the market equilibrium. Specifically, financial interconnectedness between the firms can result in the retailer financing the entire capacity in the market. In addition, we characterize the conditions that ensure that information between the retailer and the supplier can be exchanged via cheap-talk communication. Interestingly, a high level of information asymmetry facilitates the exchange of information via cheap talk in the presence of these financial links. When cheap talk is not possible, we study the separating equilibrium that is achieved through the retailer’s commitment to order in advance. In this case, the separating quantity can either increase or decrease with the level partial vertical ownership, and this trend does not depend the actual level of the financial holdings. We further analyze the incentive of the retailer to conceal demand information by choosing a pooling equilibrium and conclude with discussing the effect of the financial interconnectedness on the parties’ operational payoffs. This paper was accepted by Jayashankar Swaminathan, operations management. Funding: N. Shamir gratefully acknowledges financial support from the Israel Science Foundation [Grant 2358/22] and The Henry Crown Institute of Business Research in Israel. T. Avinadav gratefully acknowledges financial support from the Israel Science Foundation [Grant 1571/20]. Supplemental Material: Data and the electronic companion are available at https://doi.org/10.1287/mnsc.2023.4673 .
The acquired anterior open bite: possible aetiologies and management strategies
Authors: Chesterman James , Gray David , Mannion Christopher , Beddis Hannah 
Published: January 2023

An anterior open bite (AOB) is present when there is no vertical overlap between the upper and lower incisors when the buccal segment teeth are in occlusion, and most commonly develops during childhood. This article presents a series of cases in which an AOB has developed in adulthood, together with a discussion of potential aetiological factors and management strategies. CPD/Clinical Relevance: A review of the potential causes, presentation and management of the anterior open bite, applicable to clinicians in primary and secondary care
Nonlinear optical limiting effect of porous graphene dispersions at 1064  nm
Authors: Xie Youwen , Lu Yuangang , Huang Jian , Li Xinghan , He Chongjun 
Published: January 2023

This work presents a new, to the best of our knowledge, porous graphene dispersion in ethanol that can achieve a good nonlinear optical limiting (NOL) effect at the wavelength of 1064 nm. Using the Z-scan system, the nonlinear absorption coefficient of the porous graphene dispersion with a concentration of 0.01 mg/mL was measured as 9.69×10−9cm/W. The NOL of the porous graphene dispersions in ethanol under three different concentrations (0.01, 0.02, and 0.03 mg/mL) were measured. Among them, the 1-cm-thick porous graphene dispersion with a concentration of 0.01 mg/mL has the best optical limiting effect, in which the linear transmittance is 76.7%, and the lowest transmittance is 24.9%. By using the pump-probe technique, we detected the formation and annihilation times of the scatter when the suspension interacts with the pump light. The analysis shows that the NOL mechanisms of the novel porous graphene dispersion are mainly nonlinear scattering and nonlinear absorption.