bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase Ib and Expansion Study of Gemcitabine,Nab-Paclitaxel, and Ficlatuzumab in Patients With Metastatic Pancreatic Cancer
Authors: Perez Kimberly , Chiarella Anna M , Cleary James M , Horick Nora , Weekes Colin , Abrams Thomas , Blaszkowsky Lawrence , Enzinger Peter , Giannakis Marios , Goyal Lipika , Meyerhardt Jeffrey A , Rubinson Douglas , Yurgelun Matthew B , Goessling Wolfram , Giantonio Bruce J , Brais Lauren , Germon Victoria , Stonely Danielle , Raghavan Srivatsan , Bakir Basil , Das Koushik , Pitarresi Jason R , Aguirre Andrew J , Needle Michael , Rustgi Anil K , Wolpin Brian M 
Published: February 2023

AbstractBackgroundIn preclinical pancreatic ductal adenocarcinoma (PDAC) models, inhibition of hepatocyte growth factor (HGF) signaling using ficlatuzumab, a recombinant humanized anti-HGF antibody, and gemcitabine reduced tumor burden.MethodsPatients with previously untreated metastatic PDAC enrolled in a phase Ib dose escalation study with 3 + 3 design of 2 dose cohorts of ficlatuzumab 10 and 20 mg/kg administered intravenously every other week with gemcitabine 1000 mg/m2 and albumin-bound paclitaxel 125 mg/m2 given 3 weeks on and 1 week off. This was followed by an expansion phase at the maximally tolerated dose of the combination.ResultsTwenty-six patients (sex, 12 male:14 female; median age, 68 years [range, 49-83 years]) were enrolled, 22 patients were evaluable. No dose–limiting toxicities were identified (N = 7 pts) and ficlatuzumab at 20 mg/kg was chosen as the maximum tolerated dose. Among the 21 patients treated at the MTD, best response by RECISTv1.1: 6 (29%) partial response, 12 (57%) stable disease, 1 (5%) progressive disease, and 2 (9%) not evaluable. Median progression-free survival and overall survival times were 11.0 months (95% CI, 7.6-11.4 months) and 16.2 months (95% CI, 9.1 months to not reached), respectively. Toxicities attributed to ficlatuzumab included hypoalbuminemia (grade 3, 16%; any grade, 52%) and edema (grade 3, 8%; any grade, 48%). Immunohistochemistry for c-Met pathway activation demonstrated higher tumor cell p-Met levels in patients who experienced response to therapy.ConclusionIn this phase Ib trial, ficlatuzumab, gemcitabine, and albumin-bound paclitaxel were associated with durable treatment responses and increased rates of hypoalbuminemia and edema.
Essential Entomology
Authors: McGavin George C. , Davranoglou Leonidas-Romanos , Lewington Richard 
Published: February 2023

Abstract
Insects are the most diverse multicellular organisms on Earth. With estimates of total insect species scaling to the order of several millions, it might be challenging for beginners to grasp the vastness of their diversity. This second edition of Essential Entomology offers the most comprehensive and up-to-date overview of insect orders available on the market. This book is written in simple language that is understandable to all and—as its title suggests—it is an essential read for anyone interested in entomology. Essential Entomology is addressed to undergraduate students in biology, agricultural, and forestry studies, as well as amateurs and citizen scientists of all levels. Besides the updated text, this new book boasts stunning macrophotographs of all insect orders by the world’s most renowned nature photographers. Each photo perfectly supplements Richard Lewington’s incredible illustrations. The first section of the book begins with an introduction to the Linnaean system of taxonomy, as well as basic concepts in insect morphology, physiology, and natural history. The second (and largest) section of the book introduces the reader to each insect order and reviews its diversity, identifiable characteristics, natural history, and evolutionary origin. To satisfy the curiosity of the interested reader, the end of each order provides an extensive bibliography. The final section reviews the main field techniques used for collecting insects, listing purpose and the pros and cons of each technique.
A History of Mathematical Impossibility
Authors: Lützen Jesper 
Published: February 2023

Abstract
Mathematical theorems stating that a problem cannot be solved using specific means are numerous. This book follows the history of such impossibility theorems from Greek antiquity through the early twentieth century. It reveals that many impossibility statements started out as meta-statements but ended up as mathematical theorems that were proved by mathematical methods. Until the nineteenth century, impossibility theorems were often considered of secondary interest compared with positive results. This changed during the nineteenth century and today impossibility results are among the most famous and popular theorems of mathematics. The book deals with some of the celebrated impossibility theorems in pure mathematics such as the quadrature of the circle, the duplication of the cube, the trisection of the angle, Fermat’s last theorem, the impossibility of proving the parallel postulate and Gödel’s theorem, as well as some theorems from applied mathematics such as Arrow’s impossibility theorem. Although an impossibility may sound as a negative result, impossibilities have in fact acted as a creative force in the history of mathematics, challenging mathematicians to circumvent the impossibility. The introduction of complex numbers is a case in point.
Left-Digit Bias at Lyft
Authors: List John A , Muir Ian , Pope Devin , Sun Gregory 
Published: February 2023

Abstract
Left-digit bias (or 99-cent pricing) has been discussed extensively in economics, psychology, and marketing. Despite this, we show that the rideshare company, Lyft, was not using a 99-cent pricing strategy prior to our study. Based on observational data from over 600 million Lyft sessions followed by a field experiment conducted with 21 million Lyft passengers, we provide evidence of large discontinuities in demand at dollar values. Approximately half of the downward slope of the demand curve occurs discontinuously as the price of a ride drops below a dollar value (e.g. $14.00 to $13.99). If our short-run estimates persist in the longer run, we calculate that Lyft could increase its profits by roughly $160M per year by employing a left-digit bias pricing strategy. Our results showcase the robustness of an important behavioral bias for a large, modern company and its persistence in a highly competitive market.
International Spillovers and Bailouts
Authors: Azzimonti Marina , Quadrini Vincenzo 
Published: February 2023

Abstract
We study how cross-country macroeconomic spillovers caused by sovereign default affect equilibrium bailouts. Because of portfolio diversification, the default of one country causes a macroeconomic contraction in other countries, which motivates a bailout. But why do creditor countries choose to bailout debtor countries instead of their own private sector? We show that this is because an external bailout could be cheaper than a domestic bailout. We also show that although anticipated bailouts lead to higher borrowing, they can be Pareto improving not only ex post (after a country has defaulted) but also ex ante (before the country chooses its debt).
Polysomnographic characterization of circadian blood pressure patterns in patients with obstructive sleep apnea
Authors: Pinilla Lucía , Benítez Iván D , Gracia-Lavedan Esther , Torres Gerard , Minguez Olga , Aguilà Maria , Targa Adriano , Dalmases Mireia , Mediano Olga , Masa Juan F , Masdeu Maria J , Barbé Ferran , Sánchez-de-la-Torre Manuel 
Published: February 2023

AbstractWe characterized the polysomnography (PSG) parameters associated with alterations in the circadian blood pressure (BP) pattern aiming to identify the main contributors to explain the nondipper profile in obstructive sleep apnea (OSA). This is an observational prospective-multicenter study that included participants referred to the sleep unit for suspected OSA. Following a PSG study, subjects with an apnea–hypopnea index (AHI) ≥5 events/hr were included. Two groups were established based on the 24-hr ambulatory blood pressure monitoring dipping ratio (DR; night/day BP ratio): dippers (DR ≤ 0.9) and nondippers (DR &gt; 0.9). The cohort consisted of 299 patients: 131 (43.8%) dippers and 168 (56.2%) nondippers. A significant increase in the risk of presenting a nondipper BP pattern was found along with AHI gain [odds ratio (OR) (95% CI) = 1.71 (1.28 to 2.28)]. The best AHI cutoff for predicting nondipper status was 25.2 events/hr, increasing the OR (95% CI) to 3.50 (2.02 to 6.07). The hypopnea index [OR (95% CI) = 1.70 (1.27 to 2.26)], TSat90 [OR (95% CI) = 1.41 (1.06 to 1.87)], and respiratory arousal index [OR (95% CI) = 1.74 (1.30 to 2.34)] were individually associated with the risk of a nondipping pattern. Multivariate variable selection processes identified the respiratory arousal index as the most relevant risk factor for the nondipper profile, beyond classical clinical risk factors and usual PSG metrics.
Exploring the Value of Improvisational Theater in Medical Education for Advancing the Doctor–Patient Relationship and Health Equity
Authors: Rusiecki Jennifer M. , Orlov Nicola M. , Dolan James A. , Smith Michael P. , Zhu Mengqi , Chin Marshall H. 
Published: February 2023

Purpose
Health care inequities persist, and it is difficult to teach health professions students effectively about implicit bias, structural inequities, and caring for patients from underrepresented or minoritized backgrounds. Improvisational theater (improv), where performers create everything in a spontaneous and unplanned manner, may help teach health professions trainees about advancing health equity. Core improv skills, discussion, and self-reflection can help improve communication; build trustworthy relationships with patients; and address bias, racism, oppressive systems, and structural inequities.

Method
Authors integrated a 90-minute virtual improv workshop using basic exercises into a required course for first-year medical students at University of Chicago in 2020. Sixty randomly chosen students took the workshop and 37 (62%) responded to Likert-scale and open-ended questions about strengths, impact, and areas for improvement. Eleven students participated in structured interviews about their experience.

Results
Twenty-eight (76%) of 37 students rated the workshop as very good or excellent, and 31 (84%) would recommend it to others. Over 80% of students perceived their listening and observation skills improved, and that the workshop would help them take better care of patients with experiences different than their own. Six (16%) students experienced stress during the workshop but 36 (97%) felt safe. Eleven (30%) students agreed there were meaningful discussions about systemic inequities. Qualitative interview analysis showed that students thought the workshop helped develop interpersonal skills (communication, relationship building, empathy); helped personal growth (insights into perception of self and others, ability to adapt to unexpected situations); and felt safe. Students noted the workshop helped them to be in the moment with patients and respond to the unexpected in ways more traditional communication curricula have not. The authors developed a conceptual model relating improv skills and equity teaching methods to advancing health equity.

Conclusions
Improv theater exercises can complement traditional communication curricula to advance health equity.
A Model to Improve Care and Enhance the Physician–Patient Relationship for Hospitalized Patients With Opioid Use Disorder
Authors: Ari Mim , Murray John , Dickson Sarah , Kerins Angela , Weyer George 
Published: February 2023

Problem
Opioid-related morbidity and mortality continues to accelerate, with increasing acute care events for opioid-related causes. Most patients do not receive evidence-based treatment for opioid use disorder (OUD) during acute hospitalizations despite this being an invaluable moment to initiate substance use treatment. Inpatient addiction consult services can bridge this gap and improve patient engagement and outcomes, but varying models and approaches are needed to match institutional resources.

Approach
To improve care for hospitalized patients with OUD, a work group was formed at the University of Chicago Medical Center in October 2019. An OUD consult service, run by generalists, was created as part of a series of process improvement interventions. Important collaborations with pharmacy, informatics, nursing, physicians, and community partners have occurred over the last 3 years.

Outcomes
The OUD consult service completes 40–60 new inpatient consults monthly. Between August 2019 and February 2022, the service completed 867 consults from across the institution. Most consult patients were started on medications for opioid use disorder (MOUD), and many received MOUD and naloxone at discharge. Patients who were treated by our consult service experienced lower 30-day and 90-day readmission rates compared with patients who did not receive a consult. Length of stay for patients receiving a consult was not increased.

Next Steps
Adaptable models of hospital-based addiction care are needed to improve care for hospitalized patients with OUD. Continued work to reach a higher percentage of hospitalized patients with OUD and to improve linkage to care with community collaborators are important steps to strengthen the care received by individuals with OUD in all clinical departments.
Thumb Carpometacarpal Stabilization With a Dorsal Capsule Repair Augmented With an Internal Brace
Authors: Kronlage Steven C. , Whitaker Edward Alex 
Published: February 2023

Optimal surgical treatment of first carpometacarpal joint instability remains a subject of debate. Consensus on thumb carpometacarpal stability originating with the dorsoradial ligamentous complex has shifted reconstruction techniques towards stabilization dorsally. We describe a dorsal stabilization technique with internal brace augmentation of the dorsoradial ligamentous complex. A single fellowship-trained hand surgeon treated 10 women, average age 34 years (range, 21 to 52 y) and 1 man, age 34 years, between 2019 and 2022. Average patient follow-up was 2 years. Patient satisfaction was high. Further trials are needed to determine whether the procedure will prevent or delay the presentation of thumb carpometacarpal arthrosis.
Predicting Delayed Shock in Multisystem Inflammatory Disease in Children
Authors: Levine Deborah A. , Uy Vincent , Krief William , Bornstein Cara , Daswani Dina , Patel Darshan , Kriegel Marni , Jamal Nazreen , Patel Kavita , Liang Tian , Arroyo Alexander , Strother Christopher , Lim Czer Anthoney , Langhan Melissa L. , Hassoun Ameer , Chamdawala Haamid , Kaplan Carl Philip , Waseem Muhammad , Tay Ee Tein , Mortel David , Sivitz Adam B. , Kelly Christopher , Lee Horton James , Qiu Yuqing , Gorelik Mark , Platt Shari L. , Dayan Peter 
Published: February 2023

Objectives
Patients with multisystem inflammatory disease in children (MIS-C) are at risk of developing shock. Our objectives were to determine independent predictors associated with development of delayed shock (≥3 hours from emergency department [ED] arrival) in patients with MIS-C and to derive a model predicting those at low risk for delayed shock.

Methods
We conducted a retrospective cross-sectional study of 22 pediatric EDs in the New York City tri-state area. We included patients meeting World Health Organization criteria for MIS-C and presented April 1 to June 30, 2020. Our main outcomes were to determine the association between clinical and laboratory factors to the development of delayed shock and to derive a laboratory-based prediction model based on identified independent predictors.

Results
Of 248 children with MIS-C, 87 (35%) had shock and 58 (66%) had delayed shock. A C-reactive protein (CRP) level greater than 20 mg/dL (adjusted odds ratio [aOR], 5.3; 95% confidence interval [CI], 2.4–12.1), lymphocyte percent less than 11% (aOR, 3.8; 95% CI, 1.7–8.6), and platelet count less than 220,000/uL (aOR, 4.2; 95% CI, 1.8–9.8) were independently associated with delayed shock. A prediction model including a CRP level less than 6 mg/dL, lymphocyte percent more than 20%, and platelet count more than 260,000/uL, categorized patients with MIS-C at low risk of developing delayed shock (sensitivity 93% [95% CI, 66–100], specificity 38% [95% CI, 22–55]).

Conclusions
Serum CRP, lymphocyte percent, and platelet count differentiated children at higher and lower risk for developing delayed shock. Use of these data can stratify the risk of progression to shock in patients with MIS-C, providing situational awareness and helping guide their level of care.
The Utility of Smartphone-Based Thermal Imaging in the Management and Monitoring of Microvascular Flap Procedures
Authors: Hudson Todd , Hogue Elizabeth , Mullner Donna , Herrera Fernando , Scomacao Isis 
Published: February 2023

Background
Smartphone-based thermal imaging (SBTI) has been reported in the literature to be an easy-to-use, contactless, cost-friendly alternative to standard imaging modalities in identifying flap perforators, monitoring flap perfusion, and detecting flap failure. Our systematic review and meta-analysis aimed to evaluate SBTI's accuracy in perforator identification and secondarily evaluate SBTI's utility in flap perfusion monitoring as well as ability to predict flap compromise, failure, and survival.

Methods
Following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, a systematic review was performed using PubMed from inception to 2021. Articles were uploaded into Covidence and, following duplicate deletion, were initially screened for use of SBTI in flap procedures through title and abstract screening followed by full-text review. The following data points, if provided, were extracted from each included study: study design, number of patients, patient demographics, perforator number and location, flap number and location, room temperature, cooling method, imaging distance, time from cloth removal, primary (SBTI's accuracy in perforator identification), and secondary outcomes (prediction of flap compromise/failure/survival and cost analysis). Meta-analysis was performed using RevMan v.5.

Results
The initial search yielded 153 articles. Eleven applicable studies with a total of 430 flaps from 416 patients were ultimately included. The SBTI device assessed in all included studies was FLIR ONE. Four studies assessed the SBTI's perforated detection ability and were included in meta-analysis. Smartphone-based thermal imaging correctly identified 378 (93.3%; n = 405) perforators, and computed tomography angiography (CTA) correctly identified 402 (99.2%; n = 402), although in one study SBTI found additional perforators not detected on CTA. A random-effects model was used (I
2 = 65%), and no significant difference in perforator detection ability was found between SBTI and CTA (P = 0.27).

Conclusions
This systematic review and meta-analysis supports SBTI as user- and cost-friendly ($229.99), contactless imaging modality with perforator detection ability comparable to current criterion-standard CTA. Postoperatively, SBTI outperformed Doppler ultrasound in early detection of microvascular changes causing flap compromise, allowing for prompt tissue salvage. With a minimal learning curve, SBTI seems to be a promising method of postoperative flap perfusion monitoring able to be used by all hospital ranks. Smartphone-based thermal imaging could thus increase flap monitoring frequency and lower complication rates, although further study is warranted.
High and Low Septal Strip Excision on Dorsal Preservation Rhinoplasty to Fix Septal Deviation
Authors: Öztürk Güncel 
Published: February 2023

Abstract
Rhinoplasty is one of the leading procedures among aesthetic and plastic surgery interventions. Dorsal hump and nasal deviation deformities are prevalent among the general population. Patients who have both dorsal hump and nasal deviation deformities can be considered challenging for rhinosurgeons. Dorsal preservation techniques are of great interest for obtaining better and more satisfactory aesthetic and functional results. Dorsal strip excision plays a considerable part in dorsal preservation techniques. In this study, the author defines a new method that includes excisions of low and high septal strips in the subdorsal area to straighten deviation in the lower part of the distal septum and fix it on the middle line. The present study was designed as retrospective. Sixty-nine patients met the inclusion and exclusion criteria, and their records were assessed (49 females and 20 males). The patients who were included in the study have undergone surgery with high and low septal strip excision through either push-down or let-down techniques. Patients were evaluated using the “Rhinoplasty Outcome Evaluation” (ROE) questionnaire before and 12 months after surgery. The follow-up period ranged between 12 and 20 months (median, 16.3 months). All procedures were performed by the same surgeon between October 1, 2018, and April 1, 2020. The ROE scores ranged between 82 and 100 points after 1 year. The initial median ROE score was 56.5, and it increased to 93.00 points 12 months after surgery (P < 0.001). Patient satisfaction was excellent in 88.76% of the included patients. The combination of let- and push-down methods with low to high septal strip excision resulted in favorable outcomes in patients who had concomitant hump and septal deviation deformities. This new approach presents a suitable and easy method to the surgeons who are interested in dorsal preservation rhinoplasty.
Incisional Release and Fat Grafting for the Surgical Management of Perioral Fibrosis in Scleroderma
Authors: Lagziel Tomer , Kawaji Qingwen , Hultman C. Scott 
Published: February 2023

Introduction
Scleroderma (systemic sclerosis [SSc]) is a rare autoimmune, connective tissue disorder. Perioral fibrosis is a local cutaneous complication, negatively impacting functional capabilities and aesthetic satisfaction. Fat grafting has been postulated to aid in the management of SSc fibrosis thanks to stem cell enrichment. This technique's success has been demonstrated using different graft origin sites and different injection targets. We aim to demonstrate our SSc patients' success using abdominal fat and perioral target.

Methods
We queried our records for patients with preexisting SSc who underwent incisional release and fat grafting for perioral fibrosis from 2018 to 2021. For perioral release, a semisharp cannula was tunneled under the vermilion border into the vermilion and along the skin. For grafting, cannulas were used to infiltrate the fat with a retrograde filling technique in a radial-fanning manner. Their autoimmune diagnosis, anesthetic risk assessment, systemic disease complications, and degree of presenting symptoms were reviewed along with their postoperative outcomes.

Results
From 2018 to 2021, 16 patients diagnosed with SSc were treated with incisional release and fat grafting for the management of perioral fibrosis. Of the SSc patients, 8 presented with limited SSc, and 8 presented with diffuse SSc. The mean patient age was 54.31 years. All SSc patients presented with functional symptoms with the most common concern (n = 9) being “decreased mouth opening.” Other common complaints were “difficulty eating” (n = 3) or “difficulty drinking” (n = 2). Some patients (n = 11) also presented with cosmetic concerns with “perioral rhytids” being the most common (n = 6). The mean number of systemic complications, at the time of presentation, was 3.06. The mean anesthetic risk assessment was 2.44. The average amount of fat grafted intraoperatively was 14.89 mL. Two patients with SSc required regrafting. For one patient, this was part of the original treatment plan and for the other due to fat resorption. Patients who followed up reported improved functionality and were pleased aesthetically.

Conclusions
Patients with perioral fibrosis due to SSc can benefit from autologous fat grafting. Incisional release in combination with fat grafting can enhance procedure outcomes. This technique provides beneficial functional and aesthetic outcomes. Patients with both diffuse and limited disease are appropriate candidates for this procedure.