bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transarterial Radioembolisation with Y90 Resin Microspheres and the Effect of Reimbursement Criteria in France: Final Results of the CIRT-FR Prospective Observational Study
Authors: Ronot M. , Loffroy R. , Arnold D. , Greget M. , Sengel C. , Pinaquy J. B. , Pellerin O. , Maleux G. , Peynircioglu B. , Pelage J. P. , Schaefer N. , Sangro B. , de Jong N. , Zeka B. , Urdaniz M. , Helmberger T. , Vilgrain V. 
Published: January 2025

Abstract

Purpose
This analysis of the CIRSE Registry for SIR-Spheres Therapy in France, CIRT-FR, reports on real-world outcomes of transarterial radioembolisation (TARE) with Y90 resin microspheres for hepatocellular carcinoma (HCC) and colorectal cancer liver metastases (CRLM) patients in France, focusing on safety, effectiveness and health-related quality of life (HRQoL). Results on patients treated based on national reimbursement criteria are discussed here.

Methods
Prospective, multicentre, observational study of HCC and CRLM patients treated between August 2017 and July 2020 with TARE Y90 resin microspheres. Patients were assigned to different analysis groups based on reimbursement recommendations. Follow-up period was at least 24 months with patient data collected every 3 months.

Results
In total, 252 (193 HCC, 59 CRLM) patients of CIRT-FR were included in the analysis. No differences in effectiveness, safety and HRQoL were found between analysis groups based on reimbursement recommendations. Median overall survival for HCC and CRLM was 19.0 (95% CI, 16.1–22.4) and 10.8 (95% CI, 8.0–13.5) months, respectively. Serious procedure-related adverse events occurred in 13% of the patients. HRQoL generally remained stable, with some fluctuations in function scores and symptoms.

Conclusion
In our cohorts, patients performed similarly regarding clinical outcomes irrespective of their analysis group based on reimbursement recommendations. Our results suggest that instead of restrictive reimbursement criteria, more decision-making power in selecting suitable patient groups could be given to multidisciplinary tumour boards. Results confirm that TARE with Y90 resin microspheres is an effective and safe treatment for liver cancer, with maintained HRQoL in most patients.

Graphical abstract
Factors which influence social connection among cancer caregivers: an exploratory, interview study
Authors: Yuen Eva Y. N. , Toke Shadow , Macpherson Helen , Wilson Carlene 
Published: January 2025

Abstract

Background/aims
Social connectedness is increasingly recognised as influencing health outcomes in cancer caregivers; however, there is little understanding of factors which foster feelings of social connectedness among caregivers when providing care. We sought to examine from the caregivers’ perspective, factors which contribute to perceived social connection when providing care to someone with cancer.

Methods
Semi-structured interviews were conducted with 20 caregivers of people with cancer. Participants were recruited through social media and were eligible if they were aged 18 + years and had provided care to someone with cancer in the preceding 3 years. Data were analysed thematically using NVivo.

Results
Following thematic analysis of interview data, six overarching themes emerged detailing caregivers’ experiences with social support, networks, and connectedness. Themes included: people in caregivers’ social networks and communication frequency, supportive communication with people in social networks, challenges with talking with others and seeking support, receiving instrumental support from social networks, impact of the carer role on friendships and community activities, and factors which fostered perceived connectedness.

Conclusions
For caregivers of people with cancer, our qualitative findings suggest the importance of receiving emotional and instrumental support from social networks to cope with, and alleviate the stress and strain of providing care. Development and empirical testing of strategies and interventions that improve social support seeking and subsequently perceived connectedness among caregivers are recommended to improve health and wellbeing.
Structural considerations and differences between leaf canals and secretory cavities in Asteraceae
Authors: Martínez-Quezada Daniel M. , Rojas-Leal Alicia , Villaseñor José Luis , Terrazas Teresa 
Published: January 2025

Abstract
Secretory canals are distributed among seed plants, and their diversity is concentrated in many families of angiosperms, while other internal secretory structures such as secretory cavities have been identified only in Rutaceae, Myrtaceae, and Asteraceae. Identifying and recognizing these two types of secretory structures has been complicated, mainly due to their structural similarities. In this study, the ontogeny of canals and secretory cavities in two species of Asteraceae are described and compared, to understand the structural differences between them and allow the establishment of more appropriate homology hypotheses. Leaves of Bidens odorata and Tagetes tenuifolia in different stages of development, including the apex of the stems, were collected. The samples were processed using the methacrylate technique, and longitudinal and transverse sections were made. The development of both, canals and secretory cavities, is schizogenous, in contrast to what was previously reported for other families such as Rutaceae, where they are reported as lysigenous. In Asteraceae, canals originate from cells of the procambium while cavities originate from cells of the ground meristem. The structural and developmental similarities between both types of secretory structures allow us to infer that they have a close evolutionary origin. Canals and secretory cavities in Asteraceae can be differentiated based on the number of strata of secretory epithelium and sheath, the modifications of epidermal cells and mesophyll, and the type of promeristem that gives rise to them. Probably extravascular canals give rise to cavities in leaves of Asteraceae and probably in other plant families.
The effect of mandibular advancement on pharyngeal airway space in patients with oral squamous cell carcinoma: A monocentric prospective study with computed tomography
Authors: Ritschl Lucas M. , Zink Jakob K. , Unterhuber Tobias , Weitz Jochen , Hofauer Benedikt , Wolff Klaus-Dietrich , Fichter Andreas M. , Behr Alexandra V. 
Published: January 2025

Abstract

Objectives
The presented study aimed to evaluate the effect of mandibular protrusion with a temporarily applied mandibular advancement device (MAD) on the posterior airway space and to determine a reliable metric constant based on a three-dimensional computed tomography (CT) evaluation.

Materials and methods
The study population consisted of patients with oral squamous cell carcinoma who were treated at least six months prior to the follow-up CT in supine position. Each patient received an individually adjusted MAD that was temporarily applied with three different protrusion distances (P0 = 0 mm, P4 = 4 mm, and P8 = 8 mm) during follow-up CT. The open-source software Slicer was used to calculate three parameters: minimum cross-sectional area (minCSA), mean cross-sectional area (meanCSA), and volume.

Results
The results showed a significant increase for all three parameters. The minCSA increased as follows: P0 = 236.4 mm2 ± 192.2; P4 = 309.2 mm2 ± 235.4; and P8 = 430.6 mm2 ± 265.3. The meanCSA increased significantly (p < 0.001) in all protrusion steps and all parts of the pharynx. The volume changed as follows: P0 = 24.0 cm3 ± 5.0; P4 = 29.6 cm3 ± 18.1; and P8 = 33.6 cm3 ± 19.0. The minCSA increased by 24.9 mm2 ± 13.0 per millimeter mandibular protrusion.

Conclusion and clinical relevance
The results are interesting for both conservative and surgical therapy and could find future application in dental, orthodontic, and combined oral surgical therapy. With the results of this study, surgeons and dentists may better predict the change of PAS parameter in order to better prepare for orthognathic surgery. They also could ensure the right protrusion distance for mandibular advancement devices in the case of obstructive sleep apnea.
Tolerance and intraguild commensalism: the case of the European badger and the Iberian lynx
Authors: Pérez-Vigo Isabel , Ferreras Pablo , Finat Rafael , Villafuerte Rafael 
Published: January 2025

Abstract
As a top predator, the Iberian Lynx plays a critical role in regulating mesocarnivore communities across the Iberian Peninsula. While species such as the red fox, the Egyptian mongoose, or the European wildcat develop spatial or temporal avoidance behaviours to minimise potentially lethal encounters with the lynx, the relationship between the Eurasian badger and the lynx has been described as one of peaceful coexistence. However, this has not been empirically demonstrated. For the first time, we document close encounters observed between Iberian lynxes and European badgers and shed light on their behavioural interactions. Using camera traps in Montes de Toledo, Spain—an area with a high-density lynx population – we observed that lynxes stayed attentive to the badgers’ activities without showing any signs of alertness, rejection or aggression, between them. These observations challenge traditional assumptions about interspecies interactions among mesocarnivores and provide new insights into the complex dynamics of predator communities in Mediterranean ecosystems.
A comparative study of the genetically improved Abbassa Nile tilapia strain (GIANT-G9) and a commercial strain in Egypt: growth vs. stress response
Authors: Bedir Eman Ahmed , Said Mohamed Mohamed , Al Wakeel Rasha A. , Nasr-Allah Ahmed M. , Abo-Al-Ela Haitham G. 
Published: January 2025

Abstract
Selective breeding is a potent method for developing strains with enhanced traits. This study compared the growth performance and stress responses of the genetically improved Abbassa Nile tilapia strain (G9; GIANT-G9) with a local commercial strain over 12 weeks, followed by exposure to stressors including high ammonia (10 mg TAN/L), elevated temperature (37 °C), and both for three days. The GIANT-G9 showed superior growth, including greater weight gain, final weight, length gain, specific growth rate, and protein efficiency ratio, as well as a lower feed conversion ratio and condition factor compared to the commercial strain. The expression of growth hormone in the brain of the GIANT‐G9 increased significantly after 6 weeks, although it slightly decreased after 12 weeks. Growth hormone receptor 1 expression also increased significantly after 6 weeks. Muscle insulin-like growth factors (igf1 and igf2) levels up-regulated significantly only after 12 weeks in the GIANT‐G9. Under stress, serum enzymes (alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase (ALP)) were significantly higher in the GIANT‐G9, while the commercial strain had lower levels. No significant changes were observed in liver ALP activity among stressed strains. Under stress, the GIANT‐G9 exhibited marked upregulation of splenic Toll-like receptors (tlr2, tlr9, tlr21), myeloid differentiation primary response protein 88 (myd88), nuclear factor kappa B (nf-κB), interleukin (il) 1β, and il6. Notably, il6 expression was higher than il1β in the spleen, with the opposite pattern in the head kidney. In response to immune stimulation, globulin levels significantly increased in the GIANT‐G9 but with similar values to the stressed commercial strain. Myostatin expression increased in the spleen of the stressed GIANT‐G9. The commercial strain exhibited the best liver catalase and superoxide dismutase activities under stress, while the GIANT‐G9 showed increased liver glutathione-S-transferase (GST) activity after exposure to ammonia and temperature stress. Serum lysozyme activity increased in the stressed commercial strain and under temperature stress in the GIANT‐G9 but decreased under other stress conditions. Overall, the stressed commercial strain demonstrated higher survivability than the stressed GIANT‐G9. The study revealed significant interactions between strains and stress factors. The GIANT‐G9 exhibited higher growth rates but lower antioxidant and immune capacities compared to the commercial strain at the juvenile stage of life and production cycle.
Performance of a Wild Sesame (Sesamum Spp) Phytochemical Extract for Water Disinfection
Authors: Adeeyo Adeyemi Ojutalayo , Oyetade Joshua Akinropo , Msagati Titus Alfred , Colile Nkosi , Makungo Rachel 
Published: January 2025

Abstract
The study sampled wild Sesame from open field in South Africa. The samples were pretreated while the extracts were screened for phytochemical compositions and applied for water purification using standard procedures. The physicochemical properties of sampled raw and purified water (pH, total dissolved solids, salinity turbidity and conductivity) were analyzed in situ before and after treatment in the lab, respectively. The plant’s phytochemical extract from the leaves and stem was prepared using selected solvents (methanol, cold water and warm water). The results revealed the presence of phytochemicals including tannins, phenols, flavonoids, steroids, anthraquinone, terpenoids, saponins, and phlobatannins in both the stem and leaf of the wild Sesame plant. The study shows effective percentage reduction of E. coli and total bacteria with extracts of leaf (98.5, 100.0 and 97.2%), (98.8, 100.0 and 95.0%) and stem (94.0, 95.4 and 99.0%), (99.4, 98.6 and 98.4%) using methanol, cold and warm water, respectively, at 5ml of the phytochemical extracts. This study explores the use of wild Sesame phytochemicals for disinfecting river and stream water samples, highlighting the potential for greener and sustainable water treatment. The physicochemical parameters of the treated water were within tolerable limits, especially salinity and the total dissolved solids. Thus, the extract is presented as a potential solution for water purification, aligning with SDG goals 6 (clean water), 9, and 12 (green innovations). It fills the knowledge and product gap in water treatment, causing minimal harm, consistent with the African Union's sustainable development agenda and the African Council on Water's goal for clean water. This innovation meets the criteria for technology readiness levels 2 and 3, making it ready for further development.
An experimental study on the effect of prosecutorial Brady violations on confidence in exonerating individuals wrongfully convicted of murder
Authors: Navarro John C. , Hansen Michael A. 
Published: January 2025

Abstract

Objectives
While several contributing factors can lead to wrongful convictions, it is unclear whether the public perceives these methods of exonerating convicted murderers differently.

Methods
We distributed an online survey to a nationally representative sample of 1193 individuals. After reading a prompt about the increased attention and production of digital media on wrongful convictions and exonerations, respondents were randomized into two conditions to evaluate their confidence in the exoneration of a convicted murderer across four contributing factors. The experimental condition contained the addition of prosecutorial misconduct in withholding evidence.

Results
Public confidence in wrongful conviction exonerations varied across the four contributing factors, with DNA evidence consistently held in the highest regard. Confidence then followed a descending order, beginning with police-induced forced confessions, false testimonies, and eyewitness statements, with all three showing increased confidence ratings when prosecutorial misconduct was involved.

Conclusions
The public distinguishes between contributing factors in murder exonerations. DNA is the most trusted evidence for murder exonerations regardless of misconduct, while confidence in the other contributing factors to exonerate murderers significantly increases when prosecutorial misconduct is present.
The Effect of Different Nanoparticles Surface Plasmon Polariton (SPP) Grating on Ge, Si, InP, and GaAs Photodetectors Performance
Authors: Marouf Hagar , Abdel-Salam Nariman , El-Rabaie El-Sayed M. , Rashed Ahmed Nabih Zaki , ElKhamisy Khalil M. 
Published: January 2025

Abstract
The photonics community is getting more involved in plasmonic detectors that detect light. Plasmonics permits lighting to be directed into microscopic areas in metal frameworks; this feature might imitate further advancements in the effectiveness of detectors that detect light. Plasmonic nanostructures may alter light at a subwavelength scale and have been seen as an effective way to improve photoresponsiveness in semiconductor components. A groove in a surface plasmon polaritons (SPPs) catapult which encircles a novel germanium (Ge), silicon (Si), indium phosphide (InP), and gallium arsenide (GaAs) photodetectors can be applied to improve the detector’s photocurrent, responsivity, and internal quantum efficiency of the detector. In this study, we examine the effect of a gold (Au) and a silver (Ag) SPP on Ge, Si, InP, and GaAs photodetectors. Moreover, in this study, we demonstrated that the recombination of the gold SPP with the photodetector presents higher responsivity (R) and current density (J) than that with the silver SPP in all of the examined photodetectors. The maximum responsivity when using gold nanoparticles in Ge achieves 250 A W−1, 150 A W−1 in Si, 40 A W−1 in InP, and 25 A W−1 in GaAs. The results also achieve a high current density (J) of 25 mA cm−2 in Ge gold SPP, 15 mA cm−2 in Si gold SPP, 3.6 mA cm−2 in InP gold SPP, and 1.6 mA cm−2 in GaAs gold SPP. The results demonstrated that the Ge achieves the best performance of all examined photodetectors, and the gold SPP achieves better results than the silver SPP. We utilize a 3-D finite element method (FEM) COMSOL Multiphysics 6.1 simulation tool in all experiments results.
Social Vulnerability and Biological Aging in New York City: An Electronic Health Records-Based Study
Authors: Knobel Pablo , Colicino Elena , Kloog Itai , Litke Rachel , Lane Kevin , Federman Alex , Mobbs Charles , Yitshak Sade Maayan 
Published: January 2025

Abstract
Chronological age is not an accurate predictor of morbidity and mortality risk, as individuals’ aging processes are diverse. Phenotypic age acceleration (PhenoAgeAccel) is a validated biological age measure incorporating chronological age and biomarkers from blood samples commonly used in clinical practice that can better reflect aging-related morbidity and mortality risk. The heterogeneity of age-related decline is not random, as environmental exposures can promote or impede healthy aging. Social Vulnerability Index (SVI) is a composite index accounting for different facets of the social, economic, and demographic environment grouped into four themes: socioeconomic status, household composition and disability, minority status and language, and housing and transportation. We aim to assess the concurrent and combined associations of the four SVI themes on PhenoAgeAccel and the differential effects on disadvantaged groups. We use electronic health records data from 31,913 patients from the Mount Sinai Health System (116,952 person-years) and calculate PhenoAge for years with available laboratory results (2011–2022). PhenoAge is calculated as a weighted linear combination of lab results, and PhenoAgeAccel is the differential between PhenoAge and chronological age. A decile increase in the mixture of SVI dimensions was associated with an increase of 0.23 years (95% CI 0.21, 0.25) in PhenoAgeAccel. The socioeconomic status dimension was the main driver of the association, accounting for 61% of the weight. Interaction models revealed a more substantial detrimental association for women and racial and ethnic minorities with differences in leading SVI themes. These findings suggest that neighborhood-level social vulnerability increases the biological age of its residents, increasing morbidity and mortality risks. Socioeconomic status has the larger detrimental role among the different facets of social environment.
„Sterben braucht ganz viele Ausnahmen“. Eine qualitative Studie zur hospizlich-palliativen Versorgung im Strafvollzug
Authors: Fleckinger Susanne , Schmidt-Semisch Henning 
Published: January 2025

Zusammenfassung

Hintergrund
Die Zahl älterer Gefangener nimmt u.a. aufgrund des demografischen Wandels europaweit zu. In Deutschland sind 16% der Gefangenen älter als 50 Jahre. Dies führt dazu, dass Gefangene in Haft schwer erkranken, pflegebedürftig werden und auch sterben. Bislang gibt es keine Studie zur hospizlich-palliativen Versorgung dieser Personengruppe. Die vorliegende Studie fragt aus einer pflegewissenschaftlich-hospizlichen Perspektive, welche Möglichkeiten sich im Strafvollzug für eine der Situation in Freiheit äquivalente, hospizlich-palliative Versorgung bieten.

Methode
Im Rahmen dieser qualitativen Studie wurden 14 leitfadengestützte Expert:inneninterviews mit Mitarbeitenden in ambulanten Hospizdiensten geführt sowie mit Personen, die in unterschiedlichen Funktionen mit dem Thema Sterben in einer Justizvollzugsanstalt konfrontiert sind. Die Auswertung erfolgte mit der inhaltlich strukturierenden, qualitativen Inhaltsanalyse. Die Befragten wurden über den Deutschen Hospiz- und PalliativVerband sowie via Schneeballsystem rekrutiert.

Ergebnisse und Diskussion
Die Rahmenbedingungen des Strafvollzugs bestimmen wesentlich die Möglichkeiten der hospizlich-palliativen Versorgung. Pflegefachpersonen müssen dabei mit den unterschiedlichen Anforderungen an die Gewährleistung von Sicherheit einerseits und die empathische Pflege andererseits umgehen. Ehrenamtlichen Hospizbegleiter:innen wird im Strafvollzug ambivalent begegnet: Einerseits werden sie als Störung der Vollzugsroutine wahrgenommen, andererseits aber auch als Entlastung im vollzuglichen Pflegealltag. In einzelnen Anstalten ist ein Wandel im Umgang mit Sterben, Tod und Trauer wahrnehmbar.