bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of intravitreal injection of ranibizumab versus bevacizumab for treatment of type 1 and aggressive retinopathy of prematurity in rural Egypt. A randomized clinical trial
Authors: Tawfik Ghada Mahmoud , Shahein Ezzat A , Dabour Sherif A , Hassanein Dina , Elshewy Ahmed Mohamed 
Published: December 2022

ObjectiveThe objective of this study is to evaluate the efficacy of intravitreal ranibizumab (IVR) monotherapy compared with intravitreal bevacizumab (IVB) monotherapy for treatment of type 1 and aggressive retinopathy of prematurity (ROP) in rural Egypt.Methods36 eyes of 18 infants with bilateral aggressive or type 1 ROP were recruited between September 2020 and September 2022. Mean follow-up duration was 16.53 months. IVB was injected in the right eye and IVR in the left eye, rescue injection of the same initial anti-vascular endothelial growth factor (VEGF) in case of ROP reactivation. Outcome measures included regression achieved either by single injection or multiple injections or additional laser therapy at 55 weeks’ postmenstrual age (PMA), recurrence of ROP, total retinal vascularisation time and complications.ResultsInitial regression of ROP within 1 week occurred in 11/18 eyes (61.1%) in bevacizumab group and 15/18 eyes (83.3%) in ranibizumab group (p=0.137). Primary outcome measure was achieved in 14/18 eyes (77.8%) and 16/18 eyes (88.9%) in bevacizumab and ranibizumab groups, respectively (p=0.658). Late reactivation requiring retreatment with anti-VEGF was encountered in 4/18 eyes (22.2%) and 1/18 eyes (5.6%) in bevacizumab and ranibizumab groups, respectively (p=0.338). Peripheral laser therapy on the avascular retina was done in 3/18 eyes (16.7%) in each group at mean of 55.67 weeks' PMA.ConclusionBevacizumab and ranibizumab proved to be effective regarding regression of acute ROP and continuing peripheral retinal vascularisation. Higher proportion of reactivation with bevacizumab, however, clinically non-significant. Laser therapy can be postponed to reduce its complications.Trial registration numberNCT05033106.
Impact of social deprivation on clinical outcomes of adults hospitalised with community-acquired pneumonia in England: a retrospective cohort study
Authors: Lawrence Hannah , McKeever Tricia M , Lim Wei Shen 
Published: December 2022

IntroductionSocioeconomic deprivation has been associated with an increased incidence of infection and poorer clinical outcomes during influenza pandemics and the COVID-19 pandemic. The aim of this study was to determine the relationship between deprivation and adverse clinical outcomes following hospital admission with community-acquired pneumonia (CAP), specifically 30-day all-cause mortality and non-elective hospital readmission.MethodsData from the British Thoracic Society national CAP audit on patients admitted to hospital with CAP in England between 1 December 2018 and 31 January 2019 were linked to patient-level Hospital Episode Statistics data and Index of Multiple Deprivation (IMD) scores. Multivariable logistic regression models were used to examine the association between deprivation and (a) 30-day mortality and (b) 30-day readmission with p values for trend reported. Age was examined as a potential effect modifier on the effect of IMD quintile on mortality and subsequent subanalysis in those <65 and ≥65 years was performed.ResultsOf 9165 adults admitted with CAP, 24.7% (n=2263) were in the most deprived quintile. No significant trend between deprivation and mortality was observed (p trend=0.38); however, the association between deprivation and mortality differed by age group. In adults aged<65 years, 30-day mortality was highest in the most deprived and lowest in the least deprived quintiles (4.4% vs 2.5%, aOR 1.83, 95% CI 0.84 to 4.0) with a significant trend across groups (p trend=0.04). Thirty-day readmission was highest in the most deprived quintile (17.1%) with a significant p trend across groups (p trend 0.003). Age-adjusted odds of readmission were highest in the most deprived compared with the least deprived (aOR 1.41, 95% CI 1.16 to 1.73).ConclusionsIn adults aged<65 years hospitalised with CAP in England, mortality varied inversely with indices of social deprivation. There was also a significant association between deprivation and 30-day readmission. Strategies are required to decrease health inequalities in pneumonia mortality and hospital readmissions associated with deprivation.
Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines
Authors: Hajjar Roy , Gonzalez Emmanuel , Fragoso Gabriela , Oliero Manon , Alaoui Ahmed Amine , Calvé Annie , Vennin Rendos Hervé , Djediai Souad , Cuisiniere Thibault , Laplante Patrick , Gerkins Claire , Ajayi Ayodeji Samuel , Diop Khoudia , Taleb Nassima , Thérien Sophie , Schampaert Frédéricke , Alratrout Hefzi , Dagbert François , Loungnarath Rasmy , Sebajang Herawaty , Schwenter Frank , Wassef Ramses , Ratelle Richard , Debroux Eric , Cailhier Jean-François , Routy Bertrand , Annabi Borhane , Brereton Nicholas J B , Richard Carole , Santos Manuela M 
Published: December 2022

ObjectiveColorectal cancer (CRC) is the third most diagnosed cancer, and requires surgical resection and reconnection, or anastomosis, of the remaining bowel to re-establish intestinal continuity. Anastomotic leak (AL) is a major complication that increases mortality and cancer recurrence. Our objective is to assess the causal role of gut microbiota in anastomotic healing.DesignThe causal role of gut microbiota was assessed in a murine AL model receiving faecal microbiota transplantation (FMT) from patients with CRC collected before surgery and who later developed or not, AL. Anastomotic healing and gut barrier integrity were assessed after surgery. Bacterial candidates implicated in anastomotic healing were identified using 16S rRNA gene sequencing and were isolated from faecal samples to be tested bothin vitroandin vivo.ResultsMice receiving FMT from patients that developed AL displayed poor anastomotic healing. Profiling of gut microbiota of patients and mice after FMT revealed correlations between healing parameters and the relative abundance ofAlistipes onderdonkiiandParabacteroides goldsteinii. Oral supplementation withA. onderdonkiiresulted in a higher rate of leaks in mice, while gavage withP. goldsteiniiimproved healing by exerting an anti-inflammatory effect. Patients with AL and mice receiving FMT from AL patients presented upregulation of mucosal MIP-1α, MIP-2, MCP-1 and IL-17A/F before surgery. Retrospective analysis revealed that patients with AL present higher circulating neutrophil and monocyte counts before surgery.ConclusionGut microbiota plays an important role in surgical colonic healing in patients with CRC. The impact of these findings may extend to a vast array of invasive gastrointestinal procedures.
Precarious employment and occupational injuries in Sweden between 2006 and 2014: a register-based study
Authors: Kreshpaj Bertina , Wegman David H , Burstrom Bo , Davis Letitia , Hemmingsson Tomas , Håkansta Carin , Jonsson Johanna , Johansson Gun , Kjellberg Katarina , Sanchez Martinez Nestor , Matilla-Santander Nuria , Orellana Cecilia , Bodin Theo 
Published: December 2022

BackgroundPrecarious employment (PE) has been suggested as a risk factor for occupational injuries (OIs). However, several issues such as under-reporting and time at risk pose obstacles to obtaining unbiased estimates of riskObjectiveTo investigate if PE is a risk factor for OIs in Sweden.MethodsThis register-based study included employed workers aged 18–65, resident in Sweden between 2006 and 2014. PE was operationalised as a multidimensional construct (score) and by its five items (contract insecurity, contractual temporariness, multiple jobs/multiple sectors, income level, collective bargaining agreement). Our outcome was OI in the following year. Pooled ORs for OIs in relation to PE and PE items were calculated by means of multivariate logistic regression models for women and men separately.ResultsPrecarious workers were at lower risk of OIs as compared with non-precarious workers among both males and females (OR <1) also when applying weights for under-reporting and adjusting for time at risk (part-time work). Male agencies workers had a higher risk of OIs (OR 1.19, 95% CI 1.15 to 1.23), as did male and female workers in multiple jobs/sectors (OR 1.25, 95% CI 1.23 to 1.28 and OR 1.10, 95% CI 1.07 to 1.13 respectively), and female workers in the low-income groups (OR 1.11, 95% CI 1.09 to 1.12). Low coverage of collective bargaining agreements was associated with a lower risk of OIs for both men and women (OR 0.30, 95% CI 0.29 to 0.31 and OR 0.26, 95% CI 0.24 to 0.27, respectively).ConclusionsWhile several mechanisms may explain why precarious workers in Sweden present lower risks of OIs, several dimensions of PE such as temp agency work and multiple job-holding could be important risk factors for OIs and merit further research.
Diagnóstico ecocardiográfico de hipertrofia ventricular izquierda en población pediátrica según método de normalización de masa ventricular e impacto del estado nutricional
Authors: Larios Guillermo , Trincado G Claudia , Peredo G. Soledad 
Published: December 2022

Antecedentes: la presencia de hipertrofia ventricular izquierda (HVI) es un marcador pronóstico y de severidad en condiciones de sobrecarga de presión. Se determina por masa ventricular (MV) aumentada en el ecocardiograma, debiéndose ajustar la MV por tamaño corporal en pediatría (normalización). Existen múltiples métodos de normalización, pero se desconoce si estos métodos son comparables. Objetivo: comparar distintos métodos de normalización de MV en sujetos con y sin sobrecarga de presión y evaluar el impacto del estado nutricional en el diagnóstico de HVI. Métodos: estudio de corte transversal en niños entre 5-18 años, divididos en 3 grupos: A) sin sobrecarga de presión (SSP), B) HTA (confirmado o sospecha), o C) Con cardiopatía obstructiva izquierda (CCOI, gradiente ≥25 mmHg). Se analizó antropometría, presión arterial y parámetros ecocardiográficos convencionales. Se determinó HVI por 4 métodos de normalización de MV: 1) Superficie corporal (SC) según sexo, 2) Talla2,7>51g/m2,7 3) Z-Score de Talla ≥ Z+2 y 4) Masa corporal magra ≥ Z+2. Se evaluó la concordancia de los métodos por grupo y según el diagnóstico nutricional. Resultados: se analizaron 1162 sujetos, 673(57,9%) hombres, edad 10,2 ± 3,2 años, 852(73,3%) SSP, 192(16,5%) con HTA y 118(10,2%) con CCOI. Un 38,6% presentaba malnutrición por exceso. Se observó diferencia entre los métodos para HVI en pacientes SSP y con CCOI(p=0,01), y en obesos con CCOI. La concordancia entre los métodos fue variable (rango de Kappa 0,38–0,71). Conclusiones: existe variabilidad y discrepancia entre los distintos métodos de normalización utilizados para definir HVI, influenciados por el estado nutricional.
ЛАПАРОСКОПІЧНА КОЛОРЕКТАЛЬНА ХІРУРГІЯ: АНАЛІЗ ПЕРШИХ ОПЕРАЦІЙ
Authors: Беденюк А. Д. , Гриценко Й. М. , Дзюбановський І. Я. , Запорожець В. В. , Гусак О. М. , Кіт О. В. , Гриценко С. Й. , Стефанчук С. С. 
Published: December 2022

РЕЗЮМЕ. Мета роботи – проаналізувати первинний досвід упровадження лапароскопічних технологій в хірургічне лікування пацієнтів, хворих на колоректальний рак (КРР).
Матеріал і методи. Наш досвід виконання лапароскопічних операцій включає 5 пацієнтів (2 чоловіків та 3 жінки) з КРР, котрим були виконані лапароскопічні операції в умовах Тернопільської обласної клінічної лікарні з грудня 2021 по травень 2022 року. Середній вік пацієнтів склав (62±7,84) роки (інтервал 59–74). Усім пацієнтам проведено передопераційну 3Д-КТ ангіографію та оцінено судинну анатомію брижі ободової кишки. В 3 пацієнтів були раніше проведені оперативні втручання та наявний спайковий процес, проведений лапароскопічний вісцероліз. У 2 пацієнтів пухлина проростала в бокову стінку живота, бокову стінку таза та петлю тонкої кишки відповідно, проведено комбіновані операції.
Результати. Середня крововтрата становила (120±77,3) мл (проміжок 50–250 мл). Інтраопераційний час становив (235±46,18) хв (проміжок180–300 хв). В середньому кількість видалених лімфатичних вузлів була 13±2,34 (інтервал 12–17). Відповідно до класифікації TNM стадію T1 було виявлено в 1 пацієнта, Т2 – в 1, T3 – у 3, Т4а – у 1, Т4b – у 1. У 3 пацієнтів було діагностовано високий (G1) ступінь диференціації аденокарциноми, тоді як низький (G3) ступінь виявлено у 2 пацієнтів. Метастази в регіонарні лімфатичні вузли виявлено у 2 хворих. У 3 випадках макропрепарат видаляли через 4 см розріз за Пфаненштілем, в 1 випадку через 5 см розріз над пупком та в 1 випадку через доступ у лівій мезогастральній ділянці, де згодом було сформовано сигмостому. При екстракції макропрепарату використовували захисний рукав. Ми не спостерігали жодного випадку неспроможності анастомозу чи смертності в 30-денний період. У 1 пацієнта післяопераційний період ускладнився розвитком псевдомембранозного коліту. R0 край резекції досягнуто в усіх пацієнтів.
Association of Pressure Wave Reflections With Left Ventricular Mass: a Systematic Review and Meta-Analysis
Authors: Yofoglu Lazaros K. , Karachalias Fotios , Georgakis Marios K. , Tountas Christos , Argyris Antonios A. , Zhang Yi , Papaioannou Theodoros G. , Blacher Jacques , Weber Thomas , Vlachopoulos Charalampos , Safar Michel , Protogerou Athanase D. 
Published: December 2022

Background:
Pressure wave reflections (PWRs) within the circulation are assessed at various arterial sites by various noninvasive methods. We aimed at reviewing the conflicting data regarding the hypothesis that higher PWRs are associated with higher left ventricular mass and tested whether this association stands for all available indices of PWRs, all (proximal or distal to the heart) sites of assessment, and is modified by sex, age and heart rate.

Methods:
Based on a predefined protocol applying the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines, we identified eligible for meta-analysis data regarding: augmentation index, augmentation pressure, backward pressure (Pb), reflection index, and their association with left ventricular mass index (19 studies, total population n=8686).

Results:

We found statistically significant associations, independent from blood pressure level, for all indices of PWRs at all arterial sites (carotid augmentation index; odds ratio; standardized beta coefficient [β]: 0.14 [95% CI, 0.07% to 0.21%], per SD increase), radial augmentation index (β: 0.21; 0.11 to 0.31), central augmentation pressure (β: 0.15; 0.03 to 0.27), central Pb (β: 0.23; 0.05 to 0.42), and central reflection index (β: 0.14; 0.06 to 0.22), except for aortic augmentation index as estimated by generalized transfer functions. Meta-regression analysis showed that the association between carotid augmentation index and left ventricular mass was higher among populations with higher heart rate (
P
=0.036, beta: 0.017 [95% CI, 0.001 to 0.033]) and tended to be higher in middle-aged (
P
=0.07, beta: −0.001; −0.021 to 0.001).

Conclusions:
A clinically meaningful association between PWRs and left ventricular mass, assessed at either central or peripheral arterial sites by most available methods was shown, suggesting that PWR reduction strategies might be useful. Based on the present evidence, such trials should target middle-aged populations with high normal heart rate.
Systolic Blood Pressure and Cardiovascular Risk in Patients With Diabetes: A Prospective Cohort Study
Authors: Rao Shishir , Li Yikuan , Nazarzadeh Milad , Canoy Dexter , Mamouei Mohammad , Hassaine Abdelaali , Salimi-Khorshidi Gholamreza , Rahimi Kazem 
Published: December 2022

Background:
Whether the association between systolic blood pressure (SBP) and risk of cardiovascular disease is monotonic or whether there is a nadir of optimal blood pressure remains controversial. We investigated the association between SBP and cardiovascular events in patients with diabetes across the full spectrum of SBP.

Methods:
A cohort of 49 000 individuals with diabetes aged 50 to 90 years between 1990 and 2005 was identified from linked electronic health records in the United Kingdom. Associations between SBP and cardiovascular outcomes (ischemic heart disease, heart failure, stroke, and cardiovascular death) were analyzed using a deep learning approach.

Results:
Over a median follow-up of 7.3 years, 16 378 cardiovascular events were observed. The relationship between SBP and cardiovascular events followed a monotonic pattern, with the group with the lowest baseline SBP of <120 mm Hg exhibiting the lowest risk of cardiovascular events. In comparison to the reference group with the lowest SBP (<120 mm Hg), the adjusted risk ratio for cardiovascular disease was 1.03 (95% CI, 0.97–1.10) for SBP between 120 and 129 mm Hg, 1.05 (0.99–1.11) for SBP between 130 and 139 mm Hg, 1.08 (1.01–1.15) for SBP between 140 and 149 mm Hg, 1.12 (1.03–1.20) for SBP between 150 and 159 mm Hg, and 1.19 (1.09–1.28) for SBP ≥160 mm Hg.

Conclusions:
Using deep learning modeling, we found a monotonic relationship between SBP and risk of cardiovascular outcomes in patients with diabetes, without evidence of a J-shaped relationship.
Vessel Patency and Associated Factors of Drug‐Coated Balloon for Femoropopliteal Lesion
Authors: Soga Yoshimitsu , Takahara Mitsuyoshi , Iida Osamu , Tomoi Yusuke , Kawasaki Daizo , Tanaka Akiko , Yamauchi Yasutaka , Tobita Kazuki , Kozuki Amane , Fujihara Masahiko , Ando Kenji ,   the POPCORN Investigators
Published: December 2022

Background
Although clinical trials have reported favorable outcomes after drug‐coated balloon (DCB) therapy for femoropopliteal lesions, their real‐world performance and predictors have not been well evaluated. This study aimed to elucidate 1‐year freedom from restenosis and to explore the associated factors after a DCB for femoropopliteal lesions in clinical settings.

Methods and Results
This multicenter, prospective cohort registered 3165 de novo or restenotic femoropopliteallesions (mean lesion length, 13.5±9.3 cm; chronic total occlusion, 25.9%; severe calcification, 14.6%) that underwent successful DCB (Lutonix [24.2%] and IN.PACT Admiral [75.8%]) treatment between March 2018 and December 2019. Patency was assessed at 12±2 months. The primary outcome measure was 1‐year freedom from restenosis and its associated factors. Bailout stenting was performed in 3.5% of patients. The postprocedural slow flow phenomenon was observed in 3.9% of patients. During a median follow‐up of 14.2 months, 811 patients experienced restenosis. The Kaplan–Meier estimate of freedom from restenosis was 84.5% at 12 months (79.7% at 14 months). Focal, tandem, diffuse, and occlusive restenosis accounted for 37.4%, 9.8%, 18.9%, and 33.9%, respectively. Freedom from target lesion revascularization was 91.5% at 12 months. Risk factors independently associated with 1‐year restenosis were a history of revascularization, smaller distal reference vessel diameter, severe calcification, chronic total occlusion, low‐dose DCB, and residual stenosis.

Conclusions
The 1‐year clinical outcomes after DCB use for femoropopliteal lesions in real‐world practice was favorable. The additive risk factors were associated with a lower rate of freedom from restenosis.
Displacement of Death from Home to Hospital in Historical
Perspective: The Case of Italy, 1883–2013
Authors: Colombo Asher , Molinari Rocco 
Published: December 2022

Abstract
The process of changing the location of death from home to hospital in Italy between 1883 and 2013 occurred as part of a wider, century-long shift in the attitude toward death in Western societies. A longitudinal analysis of data collected in Italian provinces, using random intercept models, reveals the extent to which the displacement of death was the result of demographical, socio-structural, and cultural processes and the extent to which the influence of these processes differed geographically throughout Italy. Results show that the displacement of deaths to hospitals during this period was largely due to the growing availability of medical facilities, to changes in the causes of death among the elderly, to decreasing family size, and to urbanization. The influence of the family and urbanization is most evident in northeastern Italy, where changes from complex to simple household structures became more common during the twentieth century.
The Dynamic Links between Renewable Energy and Environmental Quality in an Insecure Situation
Authors: Farhani Ramzi 
Published: December 2022

Abstract
The world faces two main problems: environmental degradation and the growing number of terrorist attacks. This study provides new perspectives by evaluating the links between environment quality, renewable energy consumption, terrorist attacks and the rents of natural resources for forty-six African countries over the period 1991–2017. We applied a heterogeneous panel data approach and second-generation econometric techniques, which took into account cross-sectional dependence and heterogeneity. The long-term effects were obtained by AMG and CCMG estimators. The results confirmed the existence of a cross-sectional dependence between the individuals in the panel. In addition, the long-term relationship confirms the existence of an inverted U-shaped curve between CO2 emissions and the level of GDP. Renewable energies stimulate the improvement of environmental quality in the long term whereas terrorist attacks contribute to environmental degradation. Thus, policymakers are called upon to promote renewable energies and to implement good governance of rents.
Tomba’s Unforgotten Histories
Authors: Harootunian Harry D. 
Published: December 2022

Abstract
The aim of Massimiliano Tomba’s Insurgent Universality is to return to Marxism’s original historical vocation by freeing it from the hegemony of the exchange system and the encompassing agency of value. At the heart of this project appears the recognition that time, space and thus history have been captured by capitalism and transformed into categories of its own to organise people and social relationships for capital’s programme of accumulation. In this way, capital has been able to hijack history and invert it into a representation of the real, into a historical trompe-l’œil instead of ‘presentify(ing) the past’. In this regard contemporising the past is an act of intervening in history and actualising it rather than representing it. Through this operation Tomba is able to retrieve an inventory of repressed and forgotten histories, which will unveil the sources of an ‘alternate legacy of modernity’ and radical political possibilities for the present.
De Worde, Beardsley, and the Complicated Chivalry of the Round Table
Authors: van Vianen Larissa 
Published: December 2022

Abstract
Aubrey Beardsley’s ink drawings for J.M. Dent’s 1894 edition were the first modern set of illustrations of Thomas Malory’s Morte d’Arthur published after the anonymous woodcuts in the 1498 edition printed by Wynkyn de Worde. Since their publication, Beardsley’s illustrations have been criticised for their supposed unfaithfulness to Malory’s text. This article argues however that Beardsley’s illustrations of Morte d’Arthur bear great resemblance to the 1498 woodcuts. It discusses how both sets of illustrations react to Malory’s complicated understanding of chivalry and dictate a reading of Morte d’Arthur that places emphasis on the importance of Camelot’s women and Malory’s criticism of chivalry.