bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD44 in myEloid cells is a major driver of liver inflammation and injury in alcohol-related liver disease
Authors: Rousseau Déborah , Bonnafous Stéphanie , Soysouvanh Frédéric , Sarrail Dorian , Bourinet Manon , Strazzulla Axelle , Patouraux Stéphanie , Borderie Arnaud , Dolfi Bastien , Gallerand Alexandre , Farrugia Marwin A , Orian-rousseau Véronique , Xu Yingzheng , Williams Jesse W. , Ivanov Stoyan , Tran Albert , Anty Rodolphe , Luci Carmelo , Gual Philippe 
Published: January 2025

Background and Aims:
Alcohol-related liver disease (ALD) is one of the leading causes of severe liver disease with limited pharmacological treatments for alcohol-related steatohepatitis (ASH). CD44, a glycoprotein mainly expressed in immune cells, has been implicated in multiple inflammatory diseases but has never been studied in the ALD context. We therefore studied its contribution to ASH development in mice and its expression in ALD patients

Approach and Results:
Here, we report that liver CD44 expression is associated with liver injury and inflammation and its deficiency (Cd44
-/-) partially protected mice upon chronic plus binge ethanol feeding (CPB-EtOH). CD44 deletion in myeloid cells (Cd44

myel-KO
) recapitulated the same protective effects associated with reduced inflammatory monocyte infiltration and neutrophil activation in the liver and diminished blood neutrophil-lymphocyte ratio (NLR). CD44-deficient neutrophils displayed reduced PMA-induced inflammatory mediator expression and increased phagocytosis of live bacteria. Cd44

myel-KO
mice were also protected against hepatic steatosis mediated by CPB-EtOH or chronic ethanol feeding, due in part to increased SIRT1 mediated fatty acid beta-oxidation. CD44 neutralization with antibodies strongly decreased liver injury and inflammation (hepatic neutrophil frequency) and blood NLR upon CPB-EtOH. In samples from ALD patients, hepatic CD44 expression increased with ALD severity, correlated with hepatic TNFα and CD11b expression, and CD44-expressing neutrophils were enriched in alcohol-associated hepatitis.

Conclusions:
Human and experimental evidence supports CD44 as a marker of hepatic inflammation in ALD. In addition, CD44 modulates neutrophil mobilization and functions and its targeting partially prevents liver inflammation and injury in the context of acute-on-chronic alcohol drinking.
Ocular Rosacea: An Updated Review
Authors: Mohamed-Noriega Karim , Loya-Garcia Denise , Vera-Duarte Guillermo Raul , Morales-Wong Fernando , Ortiz-Morales Gustavo , Navas Alejandro , Graue-Hernandez Enrique O. , Ramirez-Miranda Arturo 
Published: January 2025

Purpose:
Ocular rosacea is a chronic inflammatory disorder affecting the ocular surface, often associated with cutaneous rosacea. This review aims to explore its pathogenesis, treatment approaches, and future directions for management.

Methods:
A review of current literature on the pathophysiology, clinical features, and treatment strategies of ocular rosacea in adults and children (pediatric blepharokeratoconjunctivitis) was conducted. Emerging research on immune dysregulation, microbiome alterations, and potential therapeutic targets was analyzed.

Results:
Ocular rosacea involves dysregulation of the immune and neurovascular systems, with toll-like receptor activation and complement system involvement leading to chronic ocular surface inflammation. Alterations in the ocular microbiome have been implicated in disease progression. Treatment strategies emphasize a stepwise approach, incorporating ocular and skin hygiene, lifestyle modifications, and pharmacological interventions. Recent advancements in understanding the disease mechanisms have led to the exploration of targeted therapies, including biologics and small-molecule inhibitors.

Conclusions:
Ocular rosacea remains challenging to diagnose and treat, particularly in children (pediatric blepharokeratoconjunctivitis), often leading to delayed intervention and poor outcomes. A multidisciplinary approach, including new therapeutic options, holds promise for improving patient care. Further research into the genetic and molecular basis of ocular rosacea may enable more personalized treatments.
Topical Caspofungin 0.5% Monotherapy for Filamentous Fungal Keratitis
Authors: Atighehchian Mehrnaz , Ghassemi Hamed , Latifi Golshan , Ouano Dean , Abedinifar Zohreh , Zarei-Ghanavati Mehran 
Published: January 2025

Purpose:
To describe a case series of patients with 12 fungal keratitis treated with caspofungin 0.5% eye drops.

Methods:
In this study, 12 patients diagnosed with fungal keratitis were treated with topical compounded caspofungin 0.5% eye drops. The authors also reviewed the existing literature on topical caspofungin 0.5% for managing fungal keratitis.

Results:
The average age of the patients was 50.16 ± 13.74 years, and the average time to presentation was 9.66 ± 6 days from the onset of symptoms. Out of the 12 patients, 10 were males, and 2 were females. Three (25%) patients had infiltrates extending up to the mid-stromal level, whereas 9 (75%) had superficial infiltration. Topical caspofungin monotherapy successfully treated the fungal infection in 8 (66.6%) patients, whereas 4 patients required additional medication and/or surgical intervention. The average size of the infiltration was 3.44 ± 1.21 mm. The group that responded to treatment had better final visual acuity compared to the nonresponding group, with values of 0.41 ± 0.48 logarithm of the minimum angle of resolution and 1.39 ± 0.10 logarithm of the minimum angle of resolution (P-value = 0.023), respectively.

Conclusions:
Topical caspofungin 0.5% is a safe and effective treatment for selected cases of fungal keratitis. However, cases with larger or deeper initial infiltrates, or those caused by Fusarium infection, may not respond adequately to topical caspofungin monotherapy.
Effects of Dexpanthenol on Corneal Neovascularization and Inflammation on Rat Model
Authors: Isleyen Busra , Acer Semra , Celik Omer , Tok Ozlem , Tok Levent 
Published: January 2025

Purpose:
To evaluate the effect of subconjunctival injection of dexpanthenol on corneal neovascularization and inflammation in rats with induced chemical burns.

Methods:
This experimental study included 40 female albino Wistar rats. Chemical burns were induced in the right eye of all rats on the first day, and the left eye was used as a control. Rats were randomly divided into 5 groups. The no-treatment group (group 1) received no injections. Balanced salt solution injection in the sham group (group 2), dexpanthenol injection in the dexpanthenol group (group 3), bevacizumab injection in the bevacizumab group (group 4), and combined dexpanthenol and bevacizumab injection in the combined group (group 5) were administered subconjunctivally on day 7. The right corneas of all rats were photographed on days 7 and 14 to evaluate corneal neovascularization. The 2 corneal images were compared, and the differences were analyzed. All rats were euthanized, and the corneas were isolated. The levels of tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor-A, malondialdehyde (MDA), apoptosis, reduced glutathione (GSH), and total oxidant status were measured in rat corneas.

Results:
Dexpanthenol reduced corneal neovascularization, and the difference was significant compared with the no-treatment and sham groups (P < 0.05). No significant difference in corneal neovascularization was observed between the dexpanthenol and bevacizumab groups. Dexpanthenol had a significant positive effect on vascular endothelial growth factor-A, TNF-α, total oxidant status, MDA, and GSH levels compared with the sham group (P < 0.05).

Conclusions:
Dexpanthenol may help control corneal neovascularization and inflammation after chemical burns.
What Happens to Weight Following Abdominoplasty: An Analysis of 188 Consecutive Cases
Authors: Bricker Jonathan , Ferenz Sarah , Moradian Simon , Termanini Kareem , Jackson Brandon , Kim John Y. S. 
Published: January 2025

Background:
Abdominoplasty may be considered a procedure performed after a patient has already lost weight, but many surgeons have clinically observed that patients continue to lose weight in the postoperative period. This study sought to quantify continued weight loss after abdominoplasty procedures.

Methods:
A retrospective chart review was conducted on all abdominoplasty cases performed by the senior author between 2018 and 2022. Patient demographics, surgical information, and postoperative weights were all obtained. Independent samples t-tests were used for comparisons between groups.

Results:
One-hundred eighty-eight patients were included with an average age of 42.5 years and follow-up of 26.5 months. Average preoperative weight and BMI were 167.8 lbs and 27.7, respectively. Average weight loss and percentage of body weight following surgery was –5.77 lbs (-3.15%) at 3 months, -5.28 lbs (-2.77%) at 6 months, -4.02 lbs (-2.17%) at 12 months, -4.18 lbs (-2.23%) at 2 years, -4.16 lbs (-2.20%) at 3 years, and –9.8 lbs (-5.29%) at 5 years. No patient who lost weight required revision surgery for additional skin removal.

Conclusion:
Patients undergoing abdominoplasty experienced maintenance of surgical weight reduction and continued weight loss up to 5 years postoperatively. Those with higher BMIs had significantly greater weight loss that increased at later time intervals.
“Cross-Sectional Analysis of Insurance Coverage for Functional Septorhinoplasty in the United States”
Authors: Lynn Jeremy V. , Shabet Christina L. , Lee Esther C. , DuPuis Danielle T. , Gorur Roopa , Eichman Jack , Gilman Robert H. , Myers Paige L. 
Published: January 2025

Background:
The benefits and cost-effectiveness of functional septorhinoplasty have been previously demonstrated. However, reimbursement for functional septorhinoplasty by health insurance companies remains inconsistent. The purpose of this study is to define the current state of insurance coverage for functional septorhinoplasty.

Methods:
A cross-sectional analysis of insurance reimbursement for functional septorhinoplasty in the United States was designed. The top three insurance companies per state based on market share data maintained by the Kaiser Family Foundation were included. Established medical policies were gathered from insurance company websites and phone interviews, and descriptive statistics were performed. Primary outcomes included the level of and criteria for coverage.

Results:
This study included 67 insurance companies representing 88% of the United States market share. Most insurance companies offered coverage with preauthorization for rhinoplasty (61%) and septoplasty (55%). However, some companies determined coverage on a case-by-case basis (rhinoplasty 25% and septoplasty 22%), while others had no defined policy for coverage (rhinoplasty 14% and septoplasty 23%). The most common criteria for coverage of rhinoplasty included nasal deformity secondary to trauma (98%), congenital anomaly (88%), and other disease (85%). The most common criteria for coverage of septoplasty included nasal obstruction (49%), septal deviation (46%), and recurrent sinusitis (40%).

Conclusions:
Functional septorhinoplasty offers significant improvement in nasal breathing and quality of life, yet disparate insurance coverage criteria limit patient access to care. Patient-reported outcome measures data will be essential to define an evidence-based list of standardized criteria for insurance coverage of functional septorhinoplasty moving forward.
Assessing walking speed in persons with a lower-limb amputation: Test-retest reliability of the 10-m walk test
Authors: Crozara Luciano Fernandes , LaRoche Dain Patrick , Marques Nise Ribeiro , Marques Payão Spencer Luiz 
Published: January 2025

Background:
Preferred walking speed (PWS), maximal walking speed (MWS), and walking speed reserve (WSR)—the difference between MWS and PWS—can be easily obtained from the 10-m walk test (10MWT) to assess walking ability and function. However, their test-retest reliability has not been determined in persons with unilateral lower-limb amputation (LLA).

Objectives:
To determine the reliability of the PWS, MWS, and WSR obtained from the 10MWT in persons with LLA.

Study design:
Test-retest with a 48- to 120-h interval between test days.

Methods:
Test-retest relative and absolute reliability was assessed by the intraclass correlation coefficient (ICC) and the %change in mean (%CM) and coefficient of variation (CV), respectively.

Results:
Preferred walking speed showed excellent reliability between day 1 (familiarization day) and day 2 (ICC = 0.97; %CM = −1.8; CV = 7.7) and a significant speed increase from day 2 to day 3 (ICC = 0.96; %CM = 8.5, p < 0.003; CV = 7.4). Maximal walking speed showed excellent reliability between day 1 and day 2 (ICC = 0.94; %CM = 2.9; CV = 8.3) and between day 2 and day 3 (ICC = 0.94; %CM = 1.8; CV = 8.6). Overall, WSR was poorly reliable between day 1 and day 2 (ICC = 0.65; %CM = 39.2; CV = 39.2) and between day 2 and day 3 (ICC = 0.74; %CM = 30.0; CV = 30.0).

Conclusions:
Preferred walking speed obtained from a single 10MWT and MWS obtained after a 10MWT familiarization day are reliable walking speed measures for persons with LLA with similar characteristics to those of our sample. Nonetheless, it is critical that both PWS and MWS are obtained after a 10MWT familiarization to obtain a reliable WSR.
Unstable anthocyanin pigmentation inStreptocarpussect.Saintpaulia(African violet) is due to transcriptional selectivity of a single MYB gene
Authors: Kurata Daichi , Tsuzaki Tomohisa , Tatsuzawa Fumi , Shirasawa Kenta , Hirakawa Hideki , Hosokawa Munetaka 
Published: January 2025

SummarySaintpaulia(African violet) pigmentation is notoriously unstable, particularly following passage through tissue culture, but the instability mechanism is unknown. White-striped petals were thought to be due to epigenetics, but the genes involved are unknown. We confirmed that white stripes result from epigenetic regulation based on the flower color traits of plants obtained from tissue culture.Gene expression in several plant lines, anthocyanin quantification, bisulfite sequencing, and methylation analyses were used to demonstrate the presence of a single MYB gene responsible for pigment variation. We identifiedSiMYB2as the cause of variations in tissue color patterning, and that two RNAs were generated fromSiMYB2.SiMYB2-Longwas expressed in colored tissues, whileSiMYB2-Shortwas expressed only in non-colored tissues. Functional analyses revealed that SiMYB2-Long is an anthocyanin biosynthesis activator and SiMYB2-Short is non-functional. Exon 3 ofSiMYB2was generated by the insertion of a transposon-like sequence. A mutant lacking the element was obtained from cultivars with non-colored tissues. Anthocyanin content andSiMYB2-Longexpression in the mutant were greatly increased compared to wild type.Our results suggest that the white-striped petals ofSaintpauliaare not formed by periclinal chimeras but thorough the transcriptional selectivity of epigenetically regulatedSiMYB2.
Oncodrive3D: Fast and accurate detection of structural clusters of somatic mutations under positive selection
Authors: Pellegrini Stefano , Estrella Olivia Dove , Muiños Ferran , Lopez-Bigas Nuria , Gonzalez-Perez Abel 
Published: January 2025

AbstractIdentifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods that exploit different signals of positive selection in the pattern of mutations observed in genes across tumors have been developed to this end. One such signal of positive selection is clustering of mutations in areas of the three-dimensional (3D) structure of the protein above the expectation under neutrality. Methods that exploit this signal have been hindered by the paucity in proteins with experimentally solved 3D structures covering their entire sequence. Here, we present Oncodrive3D, a computational method that by exploiting AlphaFold 2 structural models extends the identification of proteins with significant mutational 3D clusters to the entire human proteome. Oncodrive3D shows sensitivity and specificity on par with state-of-the-art cancer driver gene identification methods exploiting mutational clustering, and clearly outperforms them in computational efficiency. We demonstrate, through several examples, how significant mutational 3D clusters identified by Oncodrive3D in different known or potential cancer driver genes can reveal details about the mechanism of tumorigenesis in different cancer types and in clonal hematopoiesis.
In vivoQuantification of White Matter Pathways in the Human Hippocampus
Authors: Gumus Melisa , Bourganos Athanasios , Mack Michael L. 
Published: January 2025

AbstractThe hippocampus is a key structure in cognition. Although much research has focused on defining the functions of its anatomically distinct subfields, the communication among these subfields within the hippocampal circuit, supported by white matter pathways, is theoretically key to emergent cognitive function. Yet, hippocampal white matter connections in humans have not been fully exploredin vivo. By leveraging diffusion weighted imaging and a large healthy sample (N=831), we developed a processing pipeline forin vivoquantification of human hippocampal pathways. We provided evidence for monosynaptic and trisynaptic pathway-related connections in humans, supporting the described hippocampal circuit inex vivoand animal studies. In addition to hemispheric and sex differences, the individual variability in hippocampal pathways was linked to cognitive abilities. Thus,in vivocharacterization of human hippocampal pathways highlights the individual differences within these structures and paves the way for their implications in cognition, aging, and diseases.Conflict of interestThe authors declare no conflicts of interest.
Mass spectra of doubly charmed tetraquarks
Tcc
Authors: Lin You-You , Wang Ji-Ying , Zhang Ailin 
Published: January 2025

Motivated by the first observation, to the best of our knowledge, of a doubly charmed tetraquark candidate Tcc(3875)+, we perform a systematic calculation of the masses of some constituent diquarks and the doubly charmed tetraquark states from 1S to 2P excitations in a nonrelativistic constituent quark potential model. First, the mass of the charmed spin-1 diquark is predicted with ∼3500  MeV, and the masses of the light “good” (spin-0 and isospin-0) and “bad” (spin-1 and isospin-1) antidiquark are predicted with ∼670  MeV and ∼840  MeV, respectively. The mass difference between a light good and a light bad diquark is ∼170  MeV, which is consistent with previous phenomenological analyses. The interaction between the charmed diquark and the light antidiquark is then modulated by the quark-antiquark potential in the model, and the mass spectra of doubly charmed tetraquarks from 1S to 2P excitations are calculated with the obtained masses of diquarks/antidiquarks and refitted parameters from Tcc(3875)+ and X(3872). The pattern of the mass spectra of doubly charmed tetraquarks is obtained explicitly. The 1S−1P and 1S−2S mass splittings of doubly charmed tetraquarks are about 410–430 MeV and 610–650 MeV, respectively, and this mass splittings pattern is similar to that for ordinary D mesons. The mass splittings of doubly charmed tetraquarks with a good diquark is about 10–25 MeV higher than the corresponding mass splittings of doubly charmed tetraquarks with a bad diquark from 1S to 2P excitations. When Tcc(3875)+ is assumed as a IJP=01+ ground doubly charmed tetraquark with a light good antidiquark, the next P-wave excited doubly charmed tetraquarks are predicted to have masses with an average 420–430 MeV higher. A IJP=10+ ground doubly charmed tetraquark Tcc(3834) located around 3834 MeV is also expected.

Published by the American Physical Society
2025
Gender and risk – do public listing and private ownership bank matter?
Authors: Mukhibad Hasan 
Published: January 2025

Purpose
This study aims to empirically test the influence of board member gender on insolvency risk in a two-tier system.

Design/methodology/approach
This study considers 91 banks operating in Indonesia from 2009 to 2021. It uses a two-step system generalized moment method to analyze the data.

Findings
This study reports that appointing women to the board of commissioners and as directors reduces the insolvency risk. Women’s role in reducing risk is more effective in listed and private-owned banks (POB) than in others.

Practical implications
The presence of women in boardrooms is crucial for improving financial performance and reducing financial distress in banks, particularly listed and POB. The findings of this study are expected to provide insights into board selection and appointment.

Originality/value
The extant literature on the impact of appointing women to boards on bank risk lacks a consensus because of differences in proxies in measuring gender diversity (GD). This paper conducts scenarios using four GD proxies, namely, dummy, percentage of women, Blau index and Shannon index, and two insolvency risk proxies.