bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical Profiling and Antifungal Activity of Ziziphora clinopodioides Leaf Essential Oil against the Pathogen Verticillium dahliae
Authors: Han Caixia , Mei Yu , Zhou Shixing , Shao Hua 
Published: July 2023

AbstractEssential oils (EOs) are often used as natural antifungal agents to control the growth of phytopathogenic fungi. The aim of this study was to determine the effect of Ziziphora clinopodioides leaf EO against Verticillium dahliae, a pathogenic fungus of cotton. Gas chromatography‐mass spectrometry (GC/MS) analysis revealed the presence of 15 compounds of the total of extracted oil, which was consisted of 98.79 % monoterpenes and 0.61 % sesquiterpenes. The major constituents were pulegone (62.17 %), isomenthone (18.42 %), l‐menthone (5.55 %) and piperitenone (3.99 %). The mycelial growth of Verticillium dahliae was completely inhibited at 0.24 μL/mL air under vapor phase condition. Considerable morphological variations were also observed in the fungal sclerotia at the contact phase at 3 μL/mL. This study demonstrated for the first time that Z. clinopodioides EO can effectively inhibit the growth of V. dahliae, implying that it has the potential to be explored as an antifungal agent against Verticillium Wilt of cotton.
Synthesis of Novel Pyrazole‐Oxindole Conjugates with Cytotoxicity in Human Cancer Cells via Apoptosis
Authors: Jain Pravesh M. , Gutierrez Denisse A. , Kumar Sujeet , Aguilera Renato J. , Karki Subhas S. 
Published: July 2023

AbstractA novel series of pyrazole‐oxindole conjugates were prepared and characterized as potential cytotoxic agents by FT‐IR, NMR and HR‐MS. The cytotoxic activity of these compounds was tested in the Jurkat acute T cell leukemia, CEM acute lymphoblastic leukemia, MCF10 A mammary epithelial and MDA‐MB 231 triple negative breast cancer cell lines. Among the tested conjugates, 5‐methyl‐3‐((3‐(1‐phenyl)‐3‐(p‐tolyl)‐1H‐pyrazol‐4‐yl)methylene)indolin‐2‐one 6h emerged as the most cytotoxic with a CC50 of 4.36+/−0.2 μM against Jurkat cells. The mechanism of cell death induced by 6h was investigated through the Annexin V‐FITC assay via flow cytometry. Reactive oxygen species (ROS) accumulation, mitochondrial health and the cell cycle progression were also evaluated in cells exposed to 6h. Results demonstrated that 6h induces apoptosis in a dose‐response manner, without generating ROS and/or altering mitochondrial health. In addition, 6h disrupted the cell cycle distribution causing an increase in DNA fragmentation (Sub G0‐G1), and an arrest in the G0‐G1 phase. Taken together, the 6h compound revealed a strong potential as an antineoplastic agent evidenced by its cytotoxicity in leukemia cells, the activation of apoptosis and restriction of the cell cycle progression.
Research on the Chemical Constituents against Alzheimer's Disease of the Fruits of Physalis alkekengi L. var. franchetii (Mast.) Makino
Authors: Teng Yang , Yuan Qi , Wu You , Wu Shuang , Su Jin , Zhang Pengxia , Zhang Yu 
Published: July 2023

AbstractPhysalis alkekengi L. var. franchetii (Mast.) Makino (PA) is a natural plant which is utilised as a traditional herbal medicine. It has properties that make it effective against inflammation and free radical damage. In the present study, the major constituents of four extraction parts of the fruits of PA (PAF) were investigated by combining ultra‐performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry (UPLC‐Q‐TOF‐MS). The mice model of Alzheimer's disease (AD) induced by aluminum chloride (AlCl3) combined with D‐galactose (D‐gal) was established to comprehend the mechanism behind PAF's anti‐AD activity from both behavioural and pathological perspectives. The results showed that four extraction parts of PAF (PAFE) had favorable anti‐AD effects and the ethyl acetate (EA) group showed the best activity. UPLC‐Q‐TOF‐MS analysis identified Physalin B, Nobiletin and Caffeic acid as the main anti‐AD active constituents in EA extract. This study reveals that PAF can reduce neuroinflammatory damage by inhibiting p38 mitogen‐activated protein kinase (p38 MAPK) signaling pathway, which is the theoretical basis for clinical development and utilization of PAF in AD therapy.
Prediction of residual ischemia after coronary stenting by quantitative flow ratio modulated by optical coherence tomography: Where we are now and our future perspectives
Authors: Suzuki Nobuaki 
Published: July 2023

Key Points
The present article revealed the utility of simulated residual OCT‐μQFR, which was computed from pre‐PCI angiography and OCT, by assuming full stent expansion to the intended‐to‐treat segment.
More accurate and specific PCI planning, including the decision on treatment segment and the size and length of devices, is possible using simulated residual OCT‐μQFR.
Future studies should be considered to determine whether the further plaque composition AI analysis application will support comprehensive residual risk assessment by OCT‐guided PCI.
Impact of concomitant tricuspid regurgitation on outcome after edge‐to‐edge mitral valve repair
Authors: Gröger Matthias , Zeiml Katharina P. , Schneider Leonhard M. , Rottbauer Wolfgang , Markovic Sinisa , Keßler Mirjam 
Published: July 2023

AbstractAimsTo evaluate the impact of tricuspid regurgitation (TR) on echocardiographic and functional outcome after mitral valve transcatheter edge‐to‐edge‐repair (M‐TEER).Methods and ResultsA total of 740 patients underwent M‐TEER at our center from 2010 to 2021. Patients were analyzed according to severity of concomitant TR at the time of M‐TEER procedure: low‐grade TR (grade ≤I [trace–mild], 279 patients [37.7%]), moderate TR (grade II, 170 patients [23.0%]) and high‐grade TR (grade III‐V [severe–torrential], 291 patients [39.3%]). Patients with moderate to high‐grade TR had higher morbidity. Procedural success of M‐TEER was achieved similarly in all groups (98.2% vs. 97.6% vs. 95.9%, p = 0.22). TR severity decreased rapidly and consistently after M‐TEER to only 48.0% of high‐grade TR patients after 3 months (p < 0.001) and to 46.8% after 12 months (p = 0.99). High‐grade TR patients had significantly higher mortality (21.5% vs. 18.2% vs. 11.1%, p = 0.003) up to 12 months after M‐TEER. However, high‐grade TR did not independently predict mortality (HR 1.302, 95% CI 0.937–1.810; p = 0.116). Echocardiographic and functional outcome was similar in both secondary and primary MR patients.ConclusionsHigh‐grade concomitant TR did not independently predict adverse outcome following M‐TEER. A wait‐and‐observe approach for these patients is reasonable.
Sinus node dysfunction during transcatheter assessment and stent correction of sinus venosus atrial septal defects
Authors: Sandoval Juan Pablo , Rosenthal Eric , Arias Eduardo , García‐Montes José A. , Rodríguez‐Zanella Hugo , Zabal Carlos , Kabir Saleha , Yong San Fui , Jones Matthew , Qureshi Shakeel 
Published: July 2023

AbstractCovered stent correction of a superior sinus venosus atrial septal defect is increasingly performed as an alternative to surgical repair. While sinus node dysfunction requiring pacemaker implantation may be required after surgical repair, this has not been previously reported after covered stent implantation. We reviewed the experience in two interventional centers. Balloon inflation in the superior vena cava was used to confirm the anomalous pulmonary vein drainage would be unobstructed after stent implantation. During balloon testing in 62 consecutive patients, we assessed gradients across the pulmonary vein to left atrium while monitoring the rhythm. We observed the outcomes after covered stent correction in 51 patients. In a single patient, significant bradycardia and pauses developed on repeat balloon testing and the procedure was abandoned without stent implantation. In another patient, there was no sign of sinus node dysfunction during balloon testing but several hours after stent implantation, the patient became symptomatic from sinus bradycardia and pauses and had a pacemaker implanted 3 days later. Over a year later there are some signs of improvement in sinus node function. While sinus node dysfunction has not been described previously during balloon testing or after stent implantation, this report demonstrates for the first time that it may occur. Larger registries are therefore required to monitor for this uncommon complication.
Sugars as Emerging Hydrogen Donors in the Synthesis of Alditol via Catalytic Transfer Hydrogenation
Authors: Wang Shuqi , Hui Yingshuang , Zhan Yulu , Gao Lou , Zhang Yahong , Tang Yi 
Published: July 2023

AbstractThe utilization of biomass‐derived sugars as the emerging hydrogen donor in catalytic transfer hydrogenation (CTH) reactions has received great attention in recent years. In this work, we proposed two CTH routes of alditol production in the aqueous solution, i. e. self‐disproportionation of sugar and cross CTH of different sugars. Both could realize the process of sugar towards alditol. Taking advantage of the differences in hydrogenation and dehydrogenation capabilities of different sugars, a high C4 alditol yield of 85.9 % was surprisingly obtained via cross CTH route using glucose as the hydrogen donor, which is much better than that obtained when using traditional hydrogen donor isopropanol. The CTH reactions using sugars as the hydrogen donor can not only reduce the utilization of fossil energy, but also provide a new pathway for the production of alditols.
Intermetallic Rh3Sn2 Catalysts for Selective Hydrogenation of Functionalized Nitroarenes to Aromatic Ammonia
Authors: Zuo Lu‐Jie , Xue Kun‐Ze , Xu Shi‐Long , Kong Yuan , Liang Hai‐Wei 
Published: July 2023

AbstractThe selective reduction of functionalized nitroarenes to aniline is a promising strategy to produce industrially vital aniline intermediates, while achieving high selectivity is challenging. Here, we reported the synthesis of structurally ordered Rh3Sn2 intermetallic catalysts that exhibited a high selectivity of 95.1 % in the hydrogenation of 4‐nitrostyrene to 4‐aminostyrene. Density functional theory calculation reveals that the adsorption of nitrostyrene through the nitro group on Rh3Sn2 (110) surface are great improved with the addition of the Sn atom. In addition, a significant electronic effect is formed between Rh and Sn by charge transfer that makes the Rh3Sn2 intermetallic compound more favorable for the hydrogenation of nitro group.
Parameter Identification of a Solid Oxide Fuel Cell Model under Different Temperature Conditions
Authors: Singh Parminder , Sandhu Amanpreet 
Published: July 2023

AbstractA new effective method for optimization of unknown parameters in solid oxide fuel cell (SOFC) stack models is suggested. The overall voltage of the SOFC stack depends on these predicted parameters. The goal is to reduce the mean square error (MSE) between the empirical and the predicted polarization curve obtained using the method. Black widow optimization (BWO), a metaheuristic method inspired by nature, describes the minimization process. This algorithm is made to alter the search space, avoid local optima, and deliver greater efficiency in the exploitation and exploration stages. Situations based on multidimensional benchmark functions and SOFC stack temperature variations are investigated to ascertain the system consistency.
N‐Doped Octagon‐Containing HBC as Redox and pH Chiroptical Switch in the NIR
Authors: Medel Miguel A. , Hortigüela Lidia , Lloveras Vega , Catalán‐Toledo José , Miguel Delia , Mota Antonio J. , Crivillers Núria , Campaña Araceli G. , Morcillo Sara P. 
Published: July 2023

AbstractThe optical and chiroptical properties of an aza‐HBC‐oct‐[5]helicene have been studied and also modulated by means of protonation or oxidation. In both cases, the generated species shows a new absorption band in the NIR region that is not present in the neutral species. This result enables this N‐doped nanographene to act both as optical and, remarkably, as chiroptical switch since both the CD and CPL can be modulated by external stimuli such as redox or pH changes.
Milling Medium‐Free Suzuki Coupling by Direct Mechanocatalysis: From Mixer Mills to Resonant Acoustic Mixers**
Authors: Wohlgemuth Maximilian , Schmidt Sarah , Mayer Maike , Pickhardt Wilm , Grätz Sven , Borchardt Lars 
Published: July 2023

AbstractHere we describe the development of a sustainable and cost‐effective approach for catalytic cross‐coupling reactions in mechanochemistry. It is found that the substrate‘s impact with the vessel wall alone is sufficient to initiate the reaction, thus indicating that milling balls function primarily as a mixing agent for direct mechanocatalytic Suzuki coupling. The absence of milling balls can be offset by adjusting the rheology using liquid‐assisted grinding (LAG). The LAG sweet spot of 0.25 μL mg−1 is confirmed for both resonance acoustic mixers (RAMs) and ball‐free mixer mills, and is higher than in the presence of milling balls. RAMs exhibit excellent performance in the Suzuki reaction, achieving yields of 90 % after 60 min and complete conversion after 90 min. The longevity of the milling vessel is significantly improved in a RAM, allowing for at least 20 reactions without deterioration.
2H‐Phosphindole‐Enabled Dearomatization and [4+2] Cycloaddition of (Hetero)Arenes
Authors: Luo Haotian , Wang Junjian , Tian Rongqiang , Duan Zheng 
Published: July 2023

AbstractThe heavier main group multiple bonds offer an effective tool for small molecule activation. Transient 2H‐phosphinidole working as a reactive phosphadiene system undergoes phospha‐Diels‐Alder reaction with a wide range of non‐activated aromatic carbocycles and heterocycles, including naphthalene, anthracene, phenanthrene, furan, thiophene, pyrrole, pyridine, and benzo‐fused heterocycles, affording concise access to a range of polycyclic fused rings feature with phosphorus at the bridgehead. These results demonstrate that non‐activated (hetero)arenes are capable of acting as 2π systems in [4+2] cycloaddition with highly reactive 2H‐phosphindole complex.
Separation of Mixtures of Rutin and Quercetin: Evaluating the Productivity of Preparative Chromatography
Authors: Vu Tien Dinh , Selvasembian Rangabhashiyam , Mutavdžin Ivana , Horosanskaia Elena , Lorenz Heike , Seidel-Morgenstern Andreas 
Published: July 2023

AbstractThe flavonoid rutin is present in significant amounts in the flower buds of Sophora japonica L. It offers numerous desired pharmacological effects. Under certain extraction conditions quercetin is found as a hydrolysis product which needs to be separated from rutin. This paper describes the application of liquid chromatography to solve this task. Based on the determination of adsorption equilibrium constants and column efficiencies, the productivity of the separation process is estimated, and scale‐up considerations are presented. A comparison with alternatively directly crystallizing rutin from raw extracts is also reported.
NeI2 Photofragmentation Dynamics Through Quasiclassical and Semiclassical Studies
Authors: Puentes‐Milián Loidel , García‐Alfonso Ernesto , Márquez‐Mijares Maykel , Rubayo‐Soneira Jesús 
Published: July 2023

AbstractThe triatomic system NeI2 is studied under the consideration that the diatom is found in an excited electronic state (B). The vibrational levels (v=13, …, 23) are considered within two well‐known theoretical procedures: quasi‐classical trajectories (QCT), where the classical equations of motion for nuclei are solved on a single potential energy surface (PES), and the trajectory surface hopping (TSH) method, where the same are solved in a bunch of crossed vibrational PES (diabatic representation). The trajectory surface hopping fewest switches (TSHFS) is implemented to minimize the number of hoppings, thus allowing the calculations of hopping probability between the different PES's, and the kinetic mechanism to track the dissociation path. From these calculations, several observables such as, the lifetimes, vibrational and rotational energies (I2), dissociation channels, are obtained. Our results are compared with previous experimental and theoretical work.
Cellulose Dissolution, Modification, and the Derived Hydrogel: A Review
Authors: Wu Chao , Li Jun , Zhang Yu‐qing , Li Xin , Wang Shu‐ya , Li De‐qiang 
Published: July 2023

AbstractThe cellulose‐based hydrogel has occupied a pivotal position in almost all walks of life. However, the native cellulose can not be directly used for preparing hydrogel due to the complex non‐covalent interactions. Some literature has discussed the dissolution and modification of cellulose but has yet to address the influence of the pretreatment on the as‐prepared hydrogels. Firstly, the “touching” of cellulose by derived and non‐derived solvents was introduced, namely, the dissolution of cellulose. Secondly, the “conversion” of functional groups on the cellulose surface by special routes, which is the modification of cellulose. The above‐mentioned two parts were intended to explain the changes in physicochemical properties of cellulose by these routes and their influences on the subsequent hydrogel preparation. Finally, the “reinforcement” of cellulose‐based hydrogels by physical and chemical techniques was summarized, viz., improving the mechanical properties of cellulose‐based hydrogels and the changes in the multi‐level structure of the interior of cellulose‐based hydrogels.
Analysis of optimized phase locked loop for grid synchronization of solar PV system under grid disturbances
Authors: Kumar Jalan Subham , Chitti Babu B. 
Published: July 2023

AbstractIn this work, an optimal phase locked loop (PLL) is employed to estimate the fundamental grid frequency and phase angle under grid disturbances, which largely reduces the frequency and phase error. Conventional synchronous reference frame (SRF) offers considerable results for balanced grid conditions but has poor performance under grid disturbances with improper phase detection. In this regard, gravitational search algorithm (GSA)‐based optimization is utilized to optimally tune the proportional and integral (PI) gain values of conventional SRF PLL, which ensures the proper tracking of fundamental phase angle and frequency even during abnormal grid conditions, that is, voltage unbalance, frequency variations, high‐frequency harmonics, and phase variations. Further, integral square error (ISE) criteria, settling time, and overshoot are considered as objective functions to obtain the optimal value of current gain, present in the control loop of a grid‐tied solar photovoltaic (PV) system. The supremacy of the proposed work, compared to SRF and optimal SRF PLL, is tested with MATLAB®/Simulink studies and verified by dSPACE‐1104‐based hardware‐in‐loop (HIL) results for real‐time validation.
Mechanism of action of gut microbiota and probiotic Lactobacillus rhamnosus GG on skeletal remodeling in mice
Authors: Tyagi Abdul Malik 
Published: July 2023

AbstractIntroductionGut microbiota (GM) is the collection of small organisms such as bacteria, fungi, bacteriophages and protozoans living in the intestine in symbiotics relation within their host. GM regulates host metabolism by various mechanisms.MethodsThis review aims to consolidate current information for physicians on the effect of GM on bone health. For this, an online search of the literature was conducted using the keywords gut microbiota, bone mass, osteoporosis, Lactobacillus and sex steroid.Results and ConclusionsThere is a considerable degree of variation in bone mineral density (BMD) within populations, and it is estimated that a significant component of BMD variability is due to genetics. However, the remaining causes of bone mass variance within populations remain largely unknown. A well‐recognized cause of phenotypic variation in bone mass is the composition of the microbiome. Studies have shown that germ‐free (GF) mice have higher bone mass compared to conventionally raised (CR) mice. Furthermore, GM dysbiosis, also called dysbacteriosis, is defined as any alteration in the composition of the microbial community that has been colonized in the host intestine and associated with the development of bone diseases. For instance, postmenopausal osteoporosis (PMO) and diabetes. GM can be modulated by several factors such as genetics, age, drugs, food habits and probiotics. Probiotics are defined as viable bacteria that confer health benefits by modulating GM when administered in adequate quantity. Lactobacillus rhamnosus GG (LGG) is a great example of such a probiotic. LGG has been shown to regulate bone mass in healthy mice as well as ovariectomized (OVX) mice via two different mechanisms. This review will focus on the literature regarding the mechanism by which GM and probiotic LGG regulate bone mass in healthy mice as well as in OVX mice, a model of PMO.
Erucic acid ameliorates the lipopolysaccharide‐induced memory deficit in rats through inhibited inflammation cytokines expression/caspase 3/NF‐κB pathways
Authors: Sayyed Nadeem , Hafeez Abdul , Al‐Abbasi Fahad A. , Omer Asma B , AlGhamdi Shareefa A. , Alghamdi Amira M. , Sheikh Rayan A. , Kazmi Imran 
Published: July 2023

AbstractErucic acid is a single unsaturated fatty acid that falls under the omega‐9 fatty acid family. It was suggested to treat Wistar rats with lipopolysaccharide (LPS)‐induced memory impairment and minimize cognitive impairment. A total of 30 animals were randomized: group I was normally treated group, group II was administered with LPS, group III was treated with LPS along with erucic acid at the dose of 10 mg kg–1 p.o.–1, group IV was treated with LPS along with erucic acid at 20 mg kg–1 p.o.–1 and group V was the erucic acid per se group provided at the dose of 20 mg kg–1 p.o.–1 per se. Behavioral tests were evaluated by using the Morris water maze and Y‐maze. Biochemical analysis including acetylcholine esterase (AChE), choline acetyltransferase (ChAT), glutathione (GSH), catalase activity (CAT), superoxide dismutase (SOD), and nitric oxide (NO) along with proinflammatory mediators tumor necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β), caspase 3, and neuroinflammatory biomarker (nuclear factor kappa B‐NF‐κB) were measured. Erucic acid produced substantial behavioral improvement in the Y‐maze test, including spontaneous alterations and reduced latency time during acquisition, and a longer duration of time in the consolidation phase undergoing the MWM test. Furthermore, erucic acid improved the AChE, proinflammatory markers, and oxidative stress as well as restoring endogenous antioxidant levels, ChAT, caspase 3, and NF‐κB levels. Erucic acid may be a therapeutic component for conditions related to memory disorders such as memory impairment, enhances memory functioning, and protects against neuronal damage.
Direct Electrochemical Ritter‐Type Amination of Electron‐Deficient Arenes
Authors: Fu Youtian , Zhang Ling , Sun Maolin , Cao Liming , Yang Lei , Cheng Ruihua , Ma Yueyue , Ye Jinxing 
Published: July 2023

AbstractDue to the high oxidation potentials of electron‐deficient aromatic hydrocarbons, it is difficult to achieve the direct oxidative C(sp2)−H bonds functionalizations of such substrates. Herein, we develop a Ritter‐type amination of electron‐deficient aromatics by merging electricity and sulfate. This practical and straightforward method provides a series of acetanilides from simple electron‐deficient arenes, including mono‐, di‐ and tri‐substituted arenes (22 examples, up to 75 %) with moderate to good yields under mild conditions. This method is characterized by cheap and readily available regents, atom and step economy.
Catalyst‐Free [3+2] Cycloaddition of Isoquinolinium/Pyridinium Ylides and Electron‐Deficient Alkenes
Authors: Zhou Xueting , Shi Jun , Song Jun‐Rong , Pan Wei‐Dong , Ren Hai , Wu Wei 
Published: July 2023

AbstractThe development of simple‐to‐operate methods for the preparation of indolizidine derivatives are of great importance. A mild one‐pot protocol for the [3+2] cycloaddition of isoquinolinium/pyridinium ylides and electron‐deficient alkenes using NaBH3CN as reductant has been developed. The protocol has a broad substrate scope (more than 40 examples) and provides various novel hexahydroindolizidine derivatives in high yields and excellent diastereoselectivities (up to >20/1).