bluuebunny/crossref_metadata_2025_split huggingface dataset:
Auswirkungen der Covid-19-Pandemie auf die Nutzung der
Online-Videosprechstunde von Hausärzten in Deutschland – eine
Sekundärdatenanalyse von Krankenkassendaten
Authors: Petrick Nathalie , Kreuzenbeck Cordula Charlotte Josefine 
Published: January 2023

Zusammenfassung
Hintergrund Um die Covid-19-Pandemie in Deutschland im März 2020
in den Griff zu bekommen, hat die Regierung nicht-pharmazeutische Interventionen
wie Schulschließungen, fallbezogene Maßnahmen, soziale
Distanzierung und ein Verbot aller öffentlichen Veranstaltungen
eingeführt. Angesichts dieser Umstände empfahlen
Fachgesellschaften und Verbände des Gesundheitswesens den Einsatz von
Videosprechstunden. Ziel dieser Analyse war es, statistisch relevante
Erkenntnisse über den Einsatz von Videosprechstunden vor und
während der Covid-19-Pandemie zu gewinnen
Methoden Diese Studie basiert auf der Analyse eines umfassenden
Datensatzes, der anonymisierte Daten von 5,6 Millionen
Leistungsempfängern einer großen deutschen Krankenkasse
enthält. Der Datensatz umfasste Gesundheitsleistungen vom 1. Januar 2019
bis zum 30. Juni 2020 mit 29 464 913 Patientenkontakten. Die
Ansprüche wurden in Videosprechstunden und Face-to-Face-Konsultationen
unterteilt. In diesem Beitrag werden deskriptive Statistiken vorgestellt und
Zusammenhänge zwischen Variablen analysiert
Ergebnisse Bei 8 077 aller Kontakte hatte eine Videokonsultation
stattgefunden. Dies entspricht 3,12 von 10 000 Kontakten. Es gab keinen
signifikanten Unterschied in der Nutzung von Videosprechstunden nach Geschlecht.
Das Alter unterschied sich jedoch signifikant (Chi-Quadrat=2280,01, Sig.
0,000) zwischen den Kontakten mit und ohne Nutzung der Videosprechstunde. Es ist
ein signifikanter Anstieg von bis zur 27fachen Nutzung von Videosprechstunden im
ersten Lockdown im Vergleich zum Jahr 2019 zu verzeichnen.
Schlussfolgerungen Die offensichtlich höhere Nutzung der
Telemedizin in der Altersgruppe der 50- bis 64-Jährigen und die sehr
geringe Nutzung in den nachfolgenden Gruppen der 65- bis 74-Jährigen
zeigt, dass die Nutzung der Videokonsultation altersabhängig ist und
Gegenstand einer zielgerichteten Implementierung telemedizinischer Angebote sein
sollte. Es wird von vielen vermutet, dass die Videosprechstunde durch die
Covid-19-Pandemie dramatisch angestiegen ist. In diesem großen Datensatz
gibt es dafür aber bislang keine Belege, denn der Anstieg ist im
Verhältnis zu den Patientenkontakten zwar signifikant in absoluten
Zahlen aber verschwindend gering. Qualitative Forschung zur Ermittlung der
Faktoren für Patienten und Hausärzte, die zur Nutzung der
Videosprechstunde führen oder sie behindern, sollte helfen, die
scheinbar langsame Digitalisierung im ambulanten Sektor in Deutschland zu
verbessern.
Novel SYN1 Variant in Two Brothers with Focal Epilepsy and Their Prompt Response to Valproate
Authors: Leuschner Ursula Veronika , Kleinle Stephanie , Holzinger Andreas , Neef Jochen 
Published: January 2023

AbstractSynapsins are neuron-specific phosphoproteins that modulate neurotransmitter release, synaptic plasticity, and molecular processes shaping higher brain functions. Pathogenic synapsin-1 (SYN1) variants are associated with epilepsy, intellectual disabilities, and behavioral problems. We detected a novel SYN1 variant [c.477_479delTGG (p.Gly160del)] in brothers with focal epilepsy with secondary generalization. The deleted amino acid was found to be highly conserved among mammalian species. In electroencephalography, the older brother showed a bioelectrical status epilepticus and was also diagnosed with attention deficit hyperactivity disorder. Behavioral abnormalities were seen before or after the seizures. Both patients responded quickly to treatment with valproate. Our case reports are consistent with the clinical heterogeneity of the pathogenic SYN1 variants described in the literature.
Incidence of Pregnancy-Associated Venous Thromboembolism: Second Nationwide Study
Authors: Hwang Hun-Gyu , Lee Ju Hyun , Bang Soo-Mee 
Published: January 2023

Background Pregnancy is a transient risk factor for venous thromboembolism (VTE). This second nationwide study aimed to inspect trend changes in the incidence rate of pregnancy-associated VTE (PA-VTE) during the study period (2014–2018) compared with that reported in a previous study (2006–2010).
Methods Using the Korean Health Insurance Review and Assessment Service database, we retrospectively identified all PA-VTE events using both diagnostic and medication codes.
Results Of the 124,228 VTE events, 510 (0.4%) cases of PA-VTE were identified in 499 women (median age: 34 years; range: 20–49 years). The incidence rate of PA-VTE/10,000 deliveries (PA-VTE/104D) in this second study (2.62) was 3.2 times higher than that in the first study (0.82). In the second study, the PA-VTE/104D ratio of women in their 40s (5.46) was three times higher than that of women in their 20s (1.80) (relative risk: 3.03; 95% confidence interval: 2.04–4.51; p < 0.01). The incidence rate for women in their 40s in the second study was 2.3 times higher than that in the first study. PA-VTE/104D cases occurred more frequently in multiparous than in primiparous women, in cesarean section cases compared with vaginal delivery, and in multiple rather than single pregnancies. Most PA-VTE cases occurred during the postpartum period (321/510, 62.9%), of which pulmonary embolism was the most frequently occurring type (231/321, 72%).
Conclusion Advanced maternal age, cesarean section, multiparity, and multifetal pregnancies increased the risk of PA-VTE. Obstetricians need to be cautious of VTE, particularly during the postpartum period, in high-risk pregnant patients.
Imaging Recommendations for Diagnosis, Staging, and Management of Uterine Cancer
Authors: Manchanda Smita , Subashree Anthoni Bala , Renganathan Rupa , Popat Palak Bhavesh , Dhamija Ekta , Singhal Seema , Bhatla Neerja 
Published: January 2023

AbstractUterine cancers are classified into cancers of the corpus uteri (uterine carcinomas and carcinosarcoma) and corpus uteri (sarcomas) by the AJCC staging system (eighth edition). Endometrial carcinoma is the most common amongst these with prolonged estrogen exposure being a well-known risk factor. The FIGO staging system for endometrial carcinoma is primarily surgical and includes total hysterectomy, bilateral salpingo-oophorectomy, and lymphadenectomy. Imaging is useful in the preoperative evaluation of tumor stage, especially assessment of myometrial invasion and cervical stromal extension. Dynamic contrast enhanced MRI with DWI has a high staging accuracy and is the preferred imaging modality for primary evaluation with contrast-enhanced CT abdomen being indicated for recurrent disease. PET/CT is considered superior in evaluation of lymph nodes and extra pelvic metastases.
Enhancing target language output through synchronous online learner-learner interaction
Authors: Guchte Marrit van de , Batenburg Eline van , Weijen Daphne van 
Published: January 2023

Abstract
In this study, we compared the impact of audio-, video-, and text-chat interaction on target language use during
online learner-learner interaction and on learner affect amongst adolescent learners of German as a foreign language. Repeated
measures and ANOVA analyses revealed a high percentage of target language output in all conditions for all four tasks, especially
in text- chat. Audio-chatters produced the most output and used the most meaning negotiation, compensation strategies, self-repair
and other-repair strategies. Learners in all conditions gained in enjoyment, willingness to communicate and self-efficacy. Anxiety
reduced for text-chatters. Task effects partly determined the quantity of L2 output, while condition effects determined meaning-oriented and
form-focused processing.
A case study of curriculum aspirations and classroom realities for TBLT in a remote rural secondary school in
Northwestern China
Authors: Jing Yixuan , Newton Jonathan , Jing Zhiyuan 
Published: January 2023

Abstract
School children in China’s remote Northwestern region are generally from poor farming villages where English
language education presents significant challenges, particularly since the implementation of China’s 2001 English curriculum
innovation requiring tasked-based language teaching (TBLT). This one-month field study, set in a typical rural secondary school,
investigated the degree to which the curriculum aspirations for TBLT were reflected in classroom practices in the school.
Participants were ten 7th-grade teachers of English. Data included lesson observations, interviews, and field journals. Findings
showed that classroom practices did not conform to the principles of TBLT, though some efforts in using task-like activities were
observed. The contributing factors influencing classroom practices were multifaceted with teacher education the most salient. This
result indicates that teacher preparation for TBLT needs to be tailored for the rural context if it is to have any chance of
gaining a foothold in this context.
Degenerate parametric down-conversion facilitated by exciton-plasmon polariton states in a nonlinear plasmonic cavity
Authors: Piryatinski Andrei , Sukharev Maxim 
Published: January 2023

Abstract
We study the effect of degenerate parametric down-conversion (DPDC) in an ensemble of two-level quantum emitters (QEs) coupled via near-field interactions to a single surface plasmon (SP) mode of a nonlinear plasmonic cavity. For this purpose, we develop a quantum driven-dissipative model capturing non-equilibrium dynamics of the system in which incoherently pumped QEs have transition frequency tuned near the second-harmonic response of the SPs. Considering the strong coupling regime, i.e. the SP-QE interaction rate exceeds system dissipation rates, we find a critical SP-QE coupling attributed to the phase transition between normal and lasing steady states. Examining fluctuations above the system’s steady states, we predict new elementary excitations, namely, the exciton-plasmon polaritons formed by the two-SP quanta and single-exciton states of QEs. The contribution of two-SP quanta results in the linear scaling of the SP-QE interaction rate with the number of QEs,



o

, as opposed to the

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o

-scaling known for the Dicke and Tavis–Cummings models. We further examine how SP-QE interaction scaling affects the polariton dispersions and power spectra in the vicinity of the critical coupling. For this purpose, we compare the calculation results assuming a finite ensemble of QEs and the model thermodynamic limit. The calculated power spectra predict an interplay of coherent photon emission by QEs near the second-harmonic frequency and correlated photon-pair emission at the fundamental frequency by the SPs (i.e. the photonic DPDC effect).
Color image encryption algorithm based on bidirectional spiral transformation and DNA coding
Authors: Wang Quanyv , Zhang Xiaoqiang , Zhao Xiaohu 
Published: January 2023

Abstract
The security of digital images has become increasingly important as information technology has advanced considerably. To ensure image security and improve the efficiency of image encryption, a novel color image encryption algorithm is proposed in this paper. Firstly, a novel three-dimensional chaotic system with extreme multistability is proposed and employed to generate the chaotic sequences to be used in the permutation and diffusion processes. Secondly, the proposed bidirectional spiral transformation is used to permute the R, G and B components extracted from the color plain image. Thirdly, the permuted pixel sequence is dynamically encoded into a DNA sequence. To further increase the permutation effect, the DNA sequence is permuted again using the index sequence. Finally, the dynamical DNA operations are performed to diffuse the permuted DNA sequence, and the designed look-up table method is used to quickly obtain the DNA operation results. The key space of the proposed algorithm is 10266, which is large enough to resist the brute-force attacks. The average entropy value of the cipher image of Peppers is 7.9971, which is much closer to the theoretical entropy value 8. The dynamic DNA operations process only takes up 0.032349s, which shows the advantage of the proposed look-up table method. Therefore, the proposed algorithm can be applied to the application that require high confidentiality and real-time.
Bandgap properties and multi-objective optimization of double-cone pentamode metamaterials with curved side
Authors: Zou Zhen , Xu Fengxiang , Pan Yuxiong , Fang Tengyuan 
Published: January 2023

Abstract
Pentamode metamaterials (PM) have a promising application in noise reduction fields. In this paper, in order to improve the acoustic modulation capability of PMs, several novel curve PMs are proposed by replacing the straight sides of conventional PMs with curves. At first, the elliptic PMs (EPMs) with various unit cell arrangements (i.e., triangular, square, and hexagonal) are designed, respectively, and their bandgap properties are studied numerically in detail. The EPM with hexagonal unit cell arrangement (EPMH) presents better comprehensive bandgap properties in the EPMs. Subsequently, sinusoidal and power curves are introduced into the EPMH respectively to explore the influences of curve types on bandgap properties. The results show that the bandgap properties improvement of EPMH is higher in comparison with introducing other curves, and the reasons behind these improvements are carefully disclosed in combination with the spring-mass system. Finally, to further improve the bandgap properties of EPMH, a high accuracy Kriging model is constructed according to both the Latin hypercube design and double-point infilling. The Pareto optimal solution sets are determined using a non-dominated sorting genetic algorithm (NSGA-II), and the final compromise solution is gained by employing a fitness function. The bandwidths of phononic bandgap and single mode bandgap, and the total bandwidth of optimized EPMH are increased respectively by about 114.5, 4.3, and 7.7 times than those of the conventional straight side PMs. This investigation provides a fresh strategy for designing PMs with excellent bandgap properties.
Quasinormal modes and Love numbers of Kerr black holes from AdS2 black holes
Authors: Kehagias A. , Perrone D. , Riotto A. 
Published: January 2023

Abstract
We show that the linear perturbations of any spin field in the near-zone limit of the Kerr
black hole are identical to those of an AdS2 black hole which enjoys the same basic properties
of the Kerr black hole. Thanks to this identification, we calculate the spectrum of the
quasinormal modes and the Love numbers of Kerr black holes using an AdS2/CFT1 correspondence
and a group theoretical approach.
The quantum origin of quasi de Sitter: a model independent quantum cosmological tilt
Authors: Gómez César , Jimenez Raul 
Published: January 2023

Abstract
The most robust prediction of inflation driven by a single field is the existence of a red tilt for the spectrum of curvature fluctuations that is experimentally of order 0.04. The tilt is derived solving the exact equation for quantum fluctuations in a quasi de Sitter background
with first slow-roll parameter ϵ small but non vanishing. The experimental data selects among the different inflaton potentials. The origin of the lack of scale invariance associated with the tilt is however classical in essence and parametrized by the slow roll parameter of the inflaton potential. Here we present a purely quantum mechanical and model independent derivation of the tilt. This derivation is based on two basic observations: first, the correlator for the Mukhanov-Sasaki gauge invariant variables is related to the quantum Fisher function measuring the quantum dependence of the family of pure de Sitter vacua on the energy scale parameter; second, this quantum Fisher function has a non vanishing scale dependent red tilt that, at the energy scales of physical interest, fits the effective quasi de Sitter prediction as well as the experimental value. This is a result that is model independent and only based on the quantum features of the family of de Sitter vacua.
Small pixel high-spatial resolution photon-counting prototype IC for synchrotron applications
Authors: Grybos P. , Kleczek R. , Kmon P. , Otfinowski P. , Fajardo P. 
Published: January 2023

Abstract
This paper presents the design and simulation of a prototype chip in the CMOS 40 nm process for high spatial resolution operation at the ESRF-EBS synchrotron. The core of the prototype IC is the pixel matrix with 50 µm pitch, operating in a single photon counting mode. Each pixel contains a Charge Sensitive Amplifier (CSA) with a fast discharge block and detector leakage current compensation circuit. The CSA output is directly connected to the discriminator with an offset trimming capability. The chip is optimized for operation with a monochromatic X-ray beam with an energy of up to 30 keV. Furthermore, several algorithms of interpixel communication are implemented in the chip to increase detector spatial resolution by using the charge sharing effect.
A proton-recoil track imaging system for fast neutrons: the RIPTIDE detector
Authors: Console Camprini P. , Leone F. , Massimi C. , Musumarra A. , Pellegriti M.G. , Pisanti C. , Romano F. , Spighi R. , Terranova N. , Villa M. 
Published: January 2023

Abstract
Fast neutron detection is often based on the neutron-proton elastic scattering reaction: the ionization caused by recoil protons in a hydrogenous material constitutes the basic information for the design and development of a class of neutron detectors. Although experimental techniques have continuously improved, proton-recoil track imaging remains still at the frontier of n-detection systems, due to the high photon sensitivity required. Several state-of-the-art approaches for neutron tracking by using n-p single and double scattering — referred to as Recoil Proton Track Imaging (RPTI) — can be found in the literature. So far, they have showed limits in terms of detection efficiency, complexity, cost, and implementation. In order to address some of these deficiencies, we propose the design of RIPTIDE, a novel recoil-proton track imaging detector in which the light output produced by a fast scintillator is used to perform a complete reconstruction in space and time of the interaction events. The proposed idea is viable thanks to the dramatic advances in low noise and single photon counting achieved in the last decade by new scientific CMOS cameras as well as pixel sensors, like Timepix or MIMOSIS. In this contribution, we report the advances on the RIPTIDE concept: Geant4 Monte Carlo simulations, light collection tests as well as state-of-the-art approach to image readout, processing and fast analysis.
Design of stationary computed tomography baggage scanner with π-angle sparsity and compressed-sensing reconstruction: simulation study
Authors: Shim J. , Jeon D. , Jung Y. , Yang H. , Lim Y. , Cho H. , Seo C. , Choi K.Y. , Sone C.S. , Jang M.S. 
Published: January 2023

Abstract
Continuing our research on X-ray R&D for aviation security, we designed a novel stationary computed tomography (SCT) baggage scanner with π-angle sparsity, comprising several dozen pairs of nanotube-based X-ray source and linear array-type detector placed within a scan angle of 180° at an equiangular distance. Simultaneously, we developed a reconstruction method for the specific configuration adopting an iterative algorithm based on the popular compressed-sensing (CS) scheme. To validate the efficacy of the proposed SCT design, we conducted a series of simulations using a numerical baggage phantom before its practical implementation. The results showed that the proposed SCT design and corresponding reconstruction method significantly reduced the streak artifacts appearing in the filtered-backprojection (FBP) reconstruction, thereby considerably improving the image quality. The contrast-to-noise ratio evaluated under a test condition of 180°/P20/CS was approximately 16.2, approximately 4.7 and 1.1 times larger than those for 360°/P20/FBP and 360°/P20/CS, respectively. The proposed SCT design enables saving scan time, improving image quality, and restricting radiation exposure zone.
Engineered substrates incapable of induction of chondrogenic differentiation compared to the chondrocyte imprinted substrates
Authors: Taheri Shiva , Ghazali Zahra Sadat , Montazeri Leila , Ebrahim Fatemeh Ale , Javadpour Jafar , Kamguyan Khorshid , Thormann Esben , Renaud Philippe , Bonakdar Shahin 
Published: January 2023

Abstract
It is well established that surface topography can affect cell functions. However, finding a reproducible and reliable method for regulating stem cell behavior is still under investigation. It has been shown that cell imprinted substrates contain micro- and nanoscale structures of the cell membrane that serve as hierarchical substrates, can successfully alter stem cell fate. This study investigated the effect of the overall cell shape by fabricating silicon wafers containing pit structure in the average size of spherical-like chondrocytes using photolithography technique. We also used chondrocyte cell line (C28/I2) with spindle-like shape to produce cell imprinted substrates. The effect of all substrates on the differentiation of adipose-derived mesenchymal stem cells (ADSCs) has been studied. The AFM and scanning electron microscopy images of the prepared substrates demonstrated that the desired shapes were successfully transferred to the substrates. Differentiation of ADSCs was investigated by immunostaining for mature chondrocyte marker, collagen II, and gene expression of collagen II, Sox9, and aggrecan markers. C28/I2 imprinted substrate could effectively enhanced chondrogenic differentiation compared to regular pit patterns on the wafer. It can be concluded that cell imprinted substrates can induce differentiation signals better than engineered lithographic substrates. The nanostructures on the cell-imprinted patterns play a crucial role in harnessing cell fate. Therefore, the patterns must include the nano-topographies to have reliable and reproducible engineered substrates.
Torrefaction of almond shell as a renewable reinforcing agent for plastics: techno-economic analyses and comparison to bioethanol process
Authors: Liu Dupeng , Baral Nawa Raj , Liang Ling , Scown Corinne D , Sun Ning 
Published: January 2023

Abstract
In 2016, the US state of California alone produced nearly 3.5 billion kilograms of almonds, accounting for approximately 84% of the world’s almond production. This generated about 2.58 million metric tons (MTs) of almond residues. Almond shells are currently either burned to generate power or disposed of in landfill. Valorizing almond shells and hulls provides an opportunity to replace petroleum-derived products and divert organic material from landfill. Here we demonstrate a detailed techno-economic analysis (TEA) of an almond shell torrefaction process capable of utilizing the 520 000 MTs of almond shells produced annually in California. Our process also includes preprocessing the torrefied biomass to exploit it as a reinforcing agent for plastics. We further compared the revenue generated from the torrefied biomass and bioethanol derived from the same quantity of almond shells. We considered three different torrefaction facility scales to evaluate trade-offs between economies of scale at the facility and trucking costs to deliver almond shells. A facility that takes in 200 000 MT yr–1 of almond shells results in lower per-unit-output basis capital and operating cost relative to other smaller-scale torrefaction facilities, including 10 000 MT yr–1 and 50 000 MT yr–1, considered for analysis in this study. The large-sale facility results in a minimum selling price (MSP) of the torrefied biomass of $311.4 MT–1. An analogous TEA on converting almond residues into bioethanol is also investigated. The MSP of almond shell derived ethanol ($1.71 kg−1) is higher than that of corn ($0.48 kg−1) or cellulosic biomass ($0.88 kg−1) derived ethanol. Compared with the bioethanol route, the torrefied almond shells result in three times more revenue if utilized as a reinforcing agent for plastics.