bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ligamentum teres hepatis wrapping of the gastroduodenal artery stump protection in total laparoscopic pancreaticoduodenectomy: a single-center experience
Authors: Yu Zongdong , Wu Xiang , Hu Xiaodong , Lu Jun , Fang Shenzhe , Wang Luoluo , Ruan Yi , Lu Yeting , Zhou Xinhua , Li Hong 
Published: March 2023

Abstract
Background
Stump hemorrhage of the gastroduodenal artery (GDA) is a significant postoperative risk of pancreaticoduodenectomy (PD). We determined whether wrapping the GDA stump with the ligamentum teres hepatis (LTH) would reduce postoperative pancreaticoduodenal bleeding.
Methods
We retrospectively reviewed 148 patients who underwent laparoscopic pancreatoduodenectomy (LPD) at Li Huili Hospital of Ningbo Medical Center from November 2015 to September 2021. We compared perioperative data from 63 LPD patients without wrapping of the GDA (the unwrapped group) and 85 whose GDA stumps were wrapped (the wrapping group).
Results
There was no significant difference in the groups' baseline characteristics. The postoperative GDA stump bleeding incidence was significantly lower in the wrapped group than in the unwrapped group (7.9% vs. 0% p = 0.013). There was no significant difference in the incidence of other complications (e.g., intraabdominal infection, pancreatic fistula, biliary fistula, and gastrointestinal bleeding).
Conclusions
Using the LTH to wrap the GDA stump during LPD can reduce bleeding from the GDA stump but not the incidence of other complications.
Optimizing venous anastomosis angle for arteriovenous graft with intimal hyperplasia using computational fluid dynamics
Authors: Mok Sangkyun , Cho Seongsu , Lee Jihyeong , Kim Jang Yong , Yun Sang Seob , Park Young Jun , Park Sun Cheol , Lee Jinkee 
Published: March 2023

Abstract

Vascular access (VA), a renal failure therapy, is often performed using an arteriovenous (AV) graft for patients with veins and arteries that cannot be connected with autologous blood vessels. However, VA using AV grafts changes blood flow in the vein and damages vessels, leading to failure due to intimal hyperplasia (IH). The change in blood flow due to AV graft depends on various conditions, such as the anastomosis angle, IH shape, and position. In our study, we simulated the blood flow near the anastomosis between the vein and AV graft and investigated the effect of the anastomosis angleon blood vessel damage under various IH formation conditions. Blood vessel damage was quantitatively evaluated using hemodynamic factors, such as wall shear stress (WSS) and oscillatory shear index (OSI). We considered the flow rate decrease owing to IH formation in the vein for a realistic simulation. Our results show that a smaller anastomosis angle reduces damage to blood vessels and prevents IH formation and growth. This result is valid regardless of IH progression, shape, and position. These results can contribute to the optimization of the anastomosis angle during VA surgery to improve a patient’s prognosis.
Analysis of the Real-World Application Laws for Zhengan Xifeng Decoction in the Treatment of Hypertension Based on Machine Learning
Authors: Huan Jia-Ming , Cai Dan-Yang , Li Jie , Hua Zhen , Chen Xiao-Qing , Yang Wen-Qing , Hu Yuan-Long , Wang Yi-Fei , Li Yun-Lun 
Published: March 2023

Abstract

Hypertension is a common cardiovascular disease. Zhengan Xifeng Decoction (ZGXFD), a classic prescription for adjuvant treatment of hypertension, but its clinical application characteristics and biological information have not been comprehensively analysed. This study is based on real-world data from 7571 electronic medical records of hypertension patients treated by ZGXFD. The Apriori algorithm was used to obtain the coupled herbs of ZGXFD. A convolutional neural network was designed to measure the dose characteristic information of herbs. The topological features of the protein‒protein interaction data were used to analyse the biological information of herbs. The K-nearest neighbour model integrates the above characteristics of herbs into the same framework to observe the composition adjustment laws and mechanism of ZGXFD from multiple dimensions. Eighty-seven coupled herbs with dose characteristics were obtained. The results revealed that ZXGFD regulates cytokines and reduces the inflammatory response and metabolic disorder to achieve the purpose of adjuvant therapy. Moreover, machine learning model is used to analyze real-world data that include clinical and molecular biological data with hierarchical characteristics, which provides a micro-biological explanation for the clinical application of herbs.
Is robotic assistance more eye-catching than computer navigation in joint arthroplasty? A Google trends analysis from the point of public interest
Authors: Gao Jiaxiang , Xing Dan , Li Jiaojiao , Li Tong , Huang Cheng , Wang Weiguo 
Published: March 2023

Abstract
Computer-assisted navigation system (CAS) and robotic assisted surgery (RAS) have been widely used in joint arthroplasty, but few studies focused on public interest. We aimed to evaluate current trend and seasonality of public interest in CAS and RAS arthroplasty over the past 10 years, and forecast the future development. All data related to CAS or RAS arthroplasty from January 2012 to December 2021 were collected through Google Trends. Public interest was described by relative search volume (RSV). Pre-existing trend was evaluated by linear and exponential models. Time series analysis and ARIMA model were utilized to analyze the seasonality and future trend. R software 3.5.0 was for statistics analysis. Public interest in RAS arthroplasty has been continuously increasing (P < 0.001) and exponential model (R2=0.83, MAE=7.35, MAPE=34%, RSME=9.58) fitted better than linear one (R2=0.78, MAE=8.44, MAPE=42%, RSME=10.67). CAS arthroplasty showed a downtrend (P<0.01) with equivalent R2 (0.04) and accuracy measures (MAE=3.92, MAPE=31%, RSME=4.95). The greatest popularity of RAS was observed in July and October, while the lowest was in March and December. For CAS, a rise of public interest was in May and October, but lower values were observed in January and November. Based on ARIMA models, the popularity of RAS might continuously increase and nearly double in 2030, along with a stability with slight downtrend for CAS. Public interest in RAS arthroplasty has been continuously increasing and seems to maintain this uptrend in the next 10 years, whereas popularity of CAS arthroplasty will likely remain stable.
Detecting housing bubble in Poland: Investigation into two housing booms
Authors: Trojanek Radoslaw , Gluszak Michal , Tanas Justyna 
Published: March 2023

Abstract
The paper investigates the potential house price bubble in 18 provincial capital cities in Poland from 2000 to 2022. This is the first comprehensive effort to examine the house price exuberance throughout two housing market cycles (2000–2013 and 2014–2022, respectively). Additionally, we evaluate the risk of the housing bubble during a volatile era when the housing market in Poland was exposed to significant external shocks connected to COVID-19 and the War in Ukraine. During the 2006–2007 period, based on the price-to-income ratio, we observed explosive behaviour of house prices that is not justified by fundamentals in all cities examined. The length and precise timing of the bubble phases varied amongst regional cities. Despite this, the findings are consistent with earlier data from other nations, which adds credence to the idea that the 2007 housing bubble was a worldwide occurrence. Contrary to what is commonly believed and reported in the media, we have not seen any indications of irrational house price behaviour in Polish cities during the Covid-19 outbreak or the even more recent War in Ukraine. Contrary to the overwhelming evidence for the house price exuberance between 2006 and 2007, we conclude that there is no solid evidence of the existence of the housing bubble in recent years.
Haar wavelet collocation method for solving hyperbolic type double interfaces problem with discontinuous coefficients
Authors: Asif Muhammad , Farooq Muhammad Umar , Haider Nadeem 
Published: March 2023

Abstract
In this article, we considered wave propagation problems through heterogeneous media or hyperbolic type interface problems. A hybrid numerical technique is presented for the numerical solution (NS) of the these type of problems. The proposed method based on Haar wavelet collocation method (HWCM) and finite difference method (FDM). In this technique, the second order spatial partial derivative is approximated by truncated Haar wavelet series and temporal derivative is approximated by FDM. In case of linear hyperbolic interface problems, the resulting algebraic systems are solved by the Gauss elimination method. While in the case of nonlinear, the nonlinearity of the problem by using quasi-Newton linearization technique. The maximum absolute errors (MAEs), root mean square errors (RMSEs) and computational convergence rate (RcN ) are calculated by utilizing distinct collocation points (CPs). The convergence and stability analysis of the proposed technique are also discussed. Both the theoretical and numerical results affirms that the approximate solution catched the exact solution very well.
Macroevolutionary consequences of karyotypic changes in the neotropical Serrasalmidae fishes (Ostariophysi, Characiformes) diversification
Authors: Jacobina Uedson Pereira , Pontes Alany Itala , Costa Lucas , Sousa Gustavo 
Published: March 2023

Abstract
In the Neotropical region, one of the most diverse families of freshwater fishes is the monophyletic Serrasalmidae. Karyotypically, the family shows high diversity in chromosome numbers (2n = 54 to 64). However, little is discussed about whether the chromosomal changes are associated with cladogenetic events within this family. In the present study, we evaluated the role of chromosomal changes in the evolutionary diversification of Serrasalmidae. Our phylogenetic sampling included 36 species and revealed three main clades. The ancestral chromosome number reconstruction revealed the basic number 2n = 54 and a high frequency of ascending dysploid events in the most derived lineages. Our biogeographic reconstruction suggests an Amazonian origin of the family at 48 − 38 Mya, with independent colonization of other basins between 15 and 8 Mya. We did not find specific chromosomal changes or increased diversification rates correlated with the colonization of a new environment. On the other hand, an increase in the diversification rate was detected involving the genus Serrasalmus and Pygocentrus in the Miocene, correlated with the stasis of 2n = 60. Our data demonstrate that chromosomal rearrangements might have played an important evolutionary role in major cladogenetic events in Serrasalmidae, revealing them as a possible evolutionary driver in their diversification.
Mesenchymal stem cell-derived exosomal miR-27b-3p alleviates liver fibrosis via downregulating YAP/LOXL2 pathway
Authors: Cheng Fang , Yang Fuji , Wang Yanjin , Zhou Jing , Qian Hui , Yan Yongmin 
Published: March 2023

Abstract
Lysyl oxidase-like 2 (LOXL2) is an extracellular copper-dependent enzyme that plays a central role in fibrosis by catalyzing the crosslinking and deposition of collagen. Therapeutic LOXL2 inhibition has been shown to suppress liver fibrosis progression and promote its reversal. This study aims to investigate the efficacy and underlying mechanisms of human umbilical cord-derived exosomes (MSC-ex) in LOXL2 inhibition of liver fibrosis. MSC-ex, nonselective LOX inhibitor β-aminopropionitrile (BAPN), or PBS were administered into carbon tetrachloride (CCl4)-induced fibrotic livers. Serum LOXL2 and collagen crosslinking were assessed histologically and biochemically. MSC-ex’s mechanisms on LOXL2 regulation were investigated in human hepatic stellate cell line LX-2. We found that systemic administration of MSC-ex significantly reduced LOXL2 expression and collagen crosslinking, delaying the progression of CCl4-induced liver fibrosis. Mechanically, RNA-sequencing and fluorescence in situ hybridization (FISH) indicated that miR-27b-3p was enriched in MSC-ex and exosomal miR-27b-3p repressed Yes-associated protein (YAP) expression by targeting its 3' untranslated region in LX-2. LOXL2 was identified as a novel downstream target gene of YAP and YAP bound to the LOXL2 promoter to positively regulate transcription. Additionally, the miR-27b-3p inhibitor abrogated the anti-LOXL2 abilities of MSC-ex and diminished the antifibrotic efficacy. miR-27b-3p overexpression promoted MSC-ex mediated YAP/LOXL2 inhibition. Thus, MSC-ex may suppress LOXL2 expression through exosomal miR-27b-3p mediated YAP down-regulation. The findings here may improve our understanding of MSC-ex in liver fibrosis alleviation and provide new opportunities for clinical treatment.
New distribution records of fish species found in the Central Arctic Ocean
Authors: Zhang Ran , Li Hai , Wang Rui , Song Puqing , Li Yuan , Lin Longshan 
Published: March 2023

Abstract

The melting of sea ice in the Central Arctic Ocean (CAO) is more severe than previously expected. When this physical barrier disappears, fishing vessels without ice-breaking capability may enter the CAO ifprofitable. The international community has repeatedly called for this issue to be considered with the potential of adverse ecological consequences usually caused by unregulated fisheries.In 2021, the Agreement to Prevent Unregulated High Seas Fisheries in the Central Arctic Ocean, which took nine nations and the European Union years to negotiate, finally entered into force. The Agreementdemonstrated the lack of knowledge about CAO fishes and encouraged scientists to conduct surveys. The Scientific Coordinating Group (SCG) of the Preparatory Conference for the Agreement has had several discussions in order to provide the best available scientific information. Therefore, it is necessary to summarize the fish surveys of the Chinese National Arctic Research Expedition (CHINARE) for devoting to establish the fish composition and distribution baselines, because the CHINARE has the largest number of voyages and stations in the region. In the present study, we report a list of 30 fish species in the CAO, including the first occurrence of six fish species.
Human-centric and Semantics-based Explainable Event Detection: A Survey
Authors: Kolajo Taiwo , Daramola Olawande 
Published: March 2023

Abstract

In recent years, there has been a surge in interest in artificial intelligent systems that can provide human-centric explanations for decisions or predictions. No matter how good and efficient a model is, users or practitioners find it difficult to trust such model if they cannot understand the model or its behaviours. Incorporating explainability that is human-centric in event detection systems is significant for building a decision-making process that is more trustworthy and sustainable. Human-centric and semantics-based explainable event detection will achieve trustworthiness, explainability, and reliability, which are currently lacking in AI systems. This paper provides a survey on the human-centric explainable AI, explainable event detection, and semantics-based explainable event detection by answering some research questions that bother on the characteristics of human-centric explanations, the state of explainable AI, methods for human-centric explanations, the essence of human-centricity in explainable event detection, research efforts in explainable event solutions, and the benefits of integrating semantics into explainable event detection. The findings from the survey show the current state of human-centric explainability, the potential of integrating semantics into explainable AI, the open problems, and the future directions which can serve as steppingstones for researchers in the explainable AI domain.
The connection between diverticulosis and colonic superficial neoplastic lesions in patients who underwent screening colonoscopy
Authors: Valvano Marco , Vezzaro Valeria , Fabiani Stefano , Capannolo Annalisa , Sgamma Emanuele , Cesaro Nicola , Valerii Giorgio , Longo Salvatore , Barbera Carmelo , Lombardi Loreto , Viscido Angelo , Necozione Stefano , Latella Giovanni 
Published: March 2023

Abstract
Purpose
If could be a potential pathophysiological connection between colonic diverticula and colonic superficial neoplastic lesions, beyond the shared risk factors, has been a subject of debate in the last years.
This study tries to evaluate the association between diverticulosis and colonic neoplastic lesions.
Methods
This is a cross-sectional study including asymptomatic patients who underwent a screening colonoscopy (patients with a positive fecal occult blood test under the regional program of CRC screening), surveillance after polypectomy resection, or familiarity (first-degree relatives) between 2020-2021 to evaluate the association between diverticula and colonic polyps.
A multivariate analysis with multiple logistic regression and odds ratio (OR) to study the independent association between adenomas and adenocarcinomas was performed.
Results
1501 patients were included. A statistically significant association between adenomas or CRC alone and colonic diverticula was found (p = 0.045).
On a multivariate analysis of demographic (age, gender) and clinical parameters (familiarity for diverticula and polyps/CRC), only age was significantly associated with the development of colorectal adenomas or cancer (OR 1.05, 95% CI 1.03– 1.07, p < 0.0001).
Conclusions
This study showed a statistically significant association between diverticula and colonic adenomas. However, it is impossible to establish a cause-effect relationship due to the intrinsic characteristics of this study design.
A study with a prospective design including both patients with diverticulosis and without colonic diverticula aimed at establishing the incidence of adenoma and CRC could help to answer this relevant clinical question, since a potential association, could indicate the need for closer endoscopic surveillance.
Persistent IL-6 expression is induced in the olfactory bulb of arthritis model mice before the onset of arthritis
Authors: Otani Kazuhiro , Yoshiga Masayuki , Hirano Masashi , Matsushita Takayuki , Noda Kentaro , Kurosaka Daitaro 
Published: March 2023

Abstract
Background
Rheumatoid arthritis (RA) is complicated by psychiatric symptoms. There are many reports of abnormalities in the brains of RA patients and models of arthritis. However, it is unclear when these abnormalities appear and where they are distributed. In this study, we analyzed the spatiotemporal gene expression changes in the brains of mice with collagen-induced arthritis.
Methods
Mice were divided into three groups: i) collagen-induced arthritis (all mice developed arthritis on day 35): complete Freund’s adjuvant (CFA) and type II collagen at initial immunization, and incomplete Freund’s adjuvant (IFA) and type II collagen at booster immunization; ii) C(+/-) (50% mice developed arthritis on day 35): only IFA at booster immunization; and iii) C(-/-) (no arthritis): only CFA at initial immunization and only IFA at booster immunization. Whole brains were collected at 10 stages of arthritis and divided into six sections. RT-PCR was performed using RNA extracted from the divided brains, and the expressions of proinflammatory cytokines and glial markers were semi-quantified. At the same time, the arthritis score, body weight, and food and water intake were recorded and analyzed for correlation with brain gene expression.
Results
After booster immunization, a transient increase in ITGAM and IL-1β was observed in multiple areas. Interestingly, IL-6 was persistently expressed before the onset of arthritis in the olfactory bulb (OB), which correlated with body weight loss and decreased food intake. This characteristic change in the OB was similarly observed in the C(+/-), but not in the C(-/-). Furthermore, in the C(+/-), non-arthritis mice showed the same changes in the OB as the arthritis mice. This elevation of IL-6 persisted throughout the chronic phase to day 84.
Conclusion
Persistent elevation of IL-6 in the OB from the early stage of arthritis may be an important finding that might explain the neuropsychiatric pathophysiology of RA, which is present in the early stages of disease, and presents as a variety of symptoms over time. These findings also support the idea that the OB may be affected in early disease and persistently under particular peripheral immunoinflammatory conditions, as has been reported in a variety of neurodegenerative diseases.
Coherent Manipulation of Wavelength Interrogation Sensitivity of Surface Plasmon Polariton waves Using Grating and Dielectric Geometry
Authors: Khan Qaisar , khan Aizaz , bacha Bakht Amin , khan Majid , khesro Amir 
Published: March 2023

Abstract
The work presents coherent manipulation of wavelength interrogation sensitivity of surface plasmon polariton waves (SPPs) with respect to refractive index dλ/dnd. Significant control in sensitivity is reported with probe and control field detunings and Rabi frequency as well as decay rates. The order of diffraction and grating period of the slide play an important role in the manipulation of wavelength interrogation of sensitivity. The sensitivity increases with increasing grating period and decreases with increasing order of diffraction. The sensitivity is oscillation function of probe field detuning and Rabi frequency. A maximum value of sensitivity is reported to 800nm/RIU with probe field detuning and Rabi frequency, while minimum value of sensitivity is investigated up to 60nm/RIU with probe field detuning and decay rates. The reported results might have benefits in biomedical and optical technologies.
Conducting a systematic review and evaluation of commercially available mobile applications (apps) on a health-related topic: the TECH approach and a step-by-step methodological guide
Authors: Gasteiger Norina , Dowding Dawn , Norman Gill , McGarrigle Lisa , Eost-Telling Charlotte , Jones Debra , Vercell Amy , Ali Syed Mustafa , O’Connor Siobhan 
Published: March 2023

Abstract
Objectives: To provide an overview of the methodological considerations for conducting commercial smartphone health app reviews (mHealth reviews), with the aim of systematising the process and supporting high-quality evaluations of mHealth apps.
Design: Synthesis of our research team’s experiences of conducting and publishing various reviews of mHealth apps and hand-searching the top medical informatics journals (e.g., The Lancet Digital Health, npj Digital Medicine, Journal of Biomedical Informatics, and the Journal of the American Medical Informatics Association) over the last five years (2018-2022) to identify other app reviews to contribute to the discussion of this method and supporting framework for developing a research (review) question and determining the eligibility criteria.
Results: We present seven steps to support rigour in conducting app reviews in health: 1) writing a research question, 2) conducting scoping searches and developing the protocol, 3) determining the eligibility criteria using the TECH framework, 4) conducting the final search and screening of health apps, 5) data extraction, 6) quality, functionality, and other assessments and 7) analysis and synthesis of findings. We introduce the novel TECH approach to developing review questions and the eligibility criteria, which considers the Target user, Evaluation focus, Connectedness, and the Health domain. Patient and public involvement and engagement opportunities are acknowledged, including co-developing the protocol and undertaking quality or usability assessments.
Conclusion: Commercial mHealth app reviews can provide important insights into the health app market, including the availability of apps and their quality and functionality. We have outlined seven key steps for conducting rigorous health app reviews in addition to the TECH acronym, which can support researchers in writing research questions and determining the eligibility criteria. Future work will include a collaborative effort to develop reporting guidelines and a quality appraisal tool to ensure transparency and quality in systematic app reviews.