bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Diagnostic Laparoscopy in the Evaluation of Abdominal Trauma Patients: A Trauma Quality Improvement Program Study
Authors: Chiu Han‐Hsi , Tee Yu‐San , Hsu Chih‐Po , Hsu Ting‐An , Cheng Chi‐Tung , Liao Chien‐Hung , Hsieh Chi‐Hsun , Fu Chih‐Yuan 
Published: July 2023

AbstractPurposeWe aimed to identify factors related to delayed intervention in abdominal trauma patients who underwent diagnostic laparoscopy using a nationwide databank.MethodsFrom 2017 to 2019, abdominal trauma patients who underwent diagnostic laparoscopy were retrospectively evaluated using the Trauma Quality Improvement Program. Patients who underwent delayed interventions after a primary diagnostic laparoscopy were compared with those who did not. Factors associated with poor outcomes that are usually correlated with overlooked injuries and delayed interventions were also analyzed.ResultsOf the 5221 studied patients, 4682 (89.7%) underwent inspection without any intervention. Only 48 (0.9%) patients underwent delayed interventions after primary laparoscopy. Compared with patients receiving immediate interventions during primary diagnostic laparoscopy, patients receiving delayed interventions were more likely to have small intestine injuries (58.3% vs. 28.3%, p < 0.001). Among patients with hollow viscus injuries, a significantly higher probability of overlooked injuries that required delayed intervention was observed in patients with small intestine injuries (small intestine injury: 16.8%; gastric injury: 2.5%; large intestine injury: 5.2%). However, delayed small intestine repair did not significantly affect the risk of surgical site infection (SSI) (p = 0.249), acute kidney injury (AKI) (p = 0.998), or hospital length of stay (LOS) (p = 0.053). In contrast, significantly positive relationships between delayed large intestine repair and poor outcomes were observed (SSI, odds ratio = 19.544, p = 0.021; AKI, odds ratio = 27.368, p < 0.001; LOS, β = 13.541, p < 0.001).ConclusionsMost examinations and interventions (near 90%) were successful during primary laparoscopy for abdominal trauma patients. Small intestine injuries were easily overlooked. Delayed small intestine repair‐related poor outcomes were not observed.
McKeown Versus Ivor‐Lewis Esophagectomy for Patients with a History of Total Pharyngolaryngectomy: A Comparison Study
Authors: Kuriyama Kengo , Okamura Akihiko , Kanie Yasukazu , Maruyama Suguru , Sakamoto Kei , Kanamori Jun , Imamura Yu , Watanabe Masayuki 
Published: July 2023

AbstractBackgroundOncologic esophagectomy in patients with a history of total pharyngolaryngectomy (TPL) is challenging. There are two different esophagectomy procedures: total esophagectomy with cervical anastomosis (McKeown) and subtotal esophagectomy with intrathoracic anastomosis (Ivor‐Lewis). Differences in outcomes between McKeown and Ivor‐Lewis esophagectomies for patients with this history remain unclear.MethodsWe retrospectively reviewed 36 patients with a history of TPL who underwent oncologic esophagectomy and compared the clinical outcomes between the procedures.ResultsTwelve (33.3%) and 24 (66.7%) patients underwent McKeown and Ivor‐Lewis esophagectomies, respectively. McKeown esophagectomy was more frequently performed for the supracarinal tumors (P = 0.002). Other baseline characteristics, including the history of radiation therapy, were comparable between the groups. Postoperatively, the incidences of pneumonia and anastomotic leakage were higher in the McKeown group than in the Ivor‐Lewis group (P = 0.029 and P < 0.001, respectively). Neither tracheal necrosis nor remnant esophageal necrosis was observed. The overall and recurrence‐free survival rates were comparable between the groups (P = 0.494 and P = 0.813, respectively).ConclusionsWhen performing esophagectomy for patients with a history of TPL, if it is oncologically acceptable and technically available, Ivor‐Lewis is preferable over McKeown esophagectomy for avoiding postoperative complications.
Direct Aortic Versus Supra‐Aortic Arterial Cannulation During Surgery for Acute Type A Aortic Dissection
Authors: Juvonen Tatu , Jormalainen Mikko , Mustonen Caius , Demal Till , Fiore Antonio , Perrotti Andrea , Hervé Amélie , Mazzaro Enzo , Gatti Giuseppe , Pettinari Matteo , Peterss Sven , Buech Joscha , Nappi Francesco , Conradi Lenard , Pinto Angel G. , Rodriguez Lega Javier , Pol Marek , Kacer Petr , Dell’Aquila Angelo M. , Rukosujew Andreas , Wisniewski Konrad , Vendramin Igor , Piani Daniela , Ferrante Luisa , Rinaldi Mauro , Quintana Eduard , Pruna‐Guillen Robert , Gerelli Sebastien , Di Perna Dario , Folliguet Thierry , Acharya Metesh , Field Mark , Kuduvalli Manoj , Onorati Francesco , Rossetti Cecilia , Mäkikallio Timo , Raivio Peter , Mariscalco Giovanni , Biancari Fausto 
Published: July 2023

AbstractAimsIn this study we evaluated the impact of direct aortic cannulation versus innominate/subclavian/axillary artery cannulation on the outcome after surgery for type A aortic dissection.MethodsThe outcomes of patients included in a multicenter European registry (ERTAAD) who underwent surgery for acute type A aortic dissection with direct aortic cannulation versus those with innominate/subclavian/axillary artery cannulation, i.e. supra‐aortic arterial cannulation, were compared using propensity score matched analysis.ResultsOut of 3902 consecutive patients included in the registry, 2478 (63.5%) patients were eligible for this analysis. Direct aortic cannulation was performed in 627 (25.3%) patients, while supra‐aortic arterial cannulation in 1851 (74.7%) patients. Propensity score matching yielded 614 pairs of patients. Among them, patients who underwent surgery for TAAD with direct aortic cannulation had significantly decreased in‐hospital mortality (12.7% vs. 18.1%, p = 0.009) compared to those who had supra‐aortic arterial cannulation. Furthermore, direct aortic cannulation was associated with decreased postoperative rates of paraparesis/paraplegia (2.0 vs. 6.0%, p < 0.0001), mesenteric ischemia (1.8 vs. 5.1%, p = 0.002), sepsis (7.0 vs. 14.2%, p < 0.0001), heart failure (11.2 vs. 15.2%, p = 0.043), and major lower limb amputation (0 vs. 1.0%, p = 0.031). Direct aortic cannulation showed a trend toward decreased risk of postoperative dialysis (10.1 vs. 13.7%, p = 0.051).ConclusionsThis multicenter cohort study showed that direct aortic cannulation compared to supra‐aortic arterial cannulation is associated with a significant reduction of the risk of in‐hospital mortality after surgery for acute type A aortic dissection.Trial registrationClinicalTrials.gov Identifier: NCT04831073.
The association of dietary patterns with muscle mass and strength in old age: The Hordaland Health Study
Authors: Sabir Zoya , Dierkes Jutta , Hjartåker Anette , Rosendahl-Riise Hanne 
Published: July 2023

Abstract
Purpose
The single nutrient approach in nutrition research lacks the ability to account for synergistic relationships between dietary components. Current evidence suggests that diet quality, reflecting overall dietary intake, may influence muscle health. In a community-based observational study in Western Norway, we examined dietary patterns in relation to muscle mass and strength at age 67–70.

Methods
The current analysis was conducted in men and women of The Hordaland Health Study (HUSK), who participated in both the second (HUSK2) and third study wave (HUSK3). Dietary patterns were extracted by principal component analysis (PCA) on food frequency questionnaire (FFQ) data. Individual dietary pattern scores (DPS) for HUSK2 (age 46–49) and HUSK3 (age 67–70), and overall DPS (oDPS) were calculated. Outcome variables were appendicular skeletal muscle mass (ASMM) and handgrip strength (HGS) measured in HUSK3. The relationships of HUSK3 DPS and oDPS with ASMM and HGS were assessed by multivariate linear regression analysis adjusted for potential confounding factors.

Results
We identified three distinct dietary patterns, labelled ‘Western’, ‘Healthy’, and ‘Sweets-focused’. A significant positive association was observed between the oDPS for the ‘Healthy’ dietary pattern and ASMM in both men and women at age 67–70. No significant associations were found between HUSK3 DPS or oDPS for any of the identified dietary patterns and HGS in our population.

Conclusion
Higher oDPS on a dietary pattern predominantly rich in fish, vegetables, nuts and seeds, fruit and berries, and eggs was associated with better ASMM at age 67–70. To establish the influence of diet quality on muscle health, further long-term studies with repeated dietary assessments are warranted.
Influence of the toxicological status on the diagnosis of fatal drowning
Authors: Poulain Clément , Mathieu Olivier , Gouetta Valérie , Baccino Éric , Peyron Pierre-Antoine 
Published: July 2023

AbstractDrowning is the leading cause of death by accident of everyday life in people under 25 years of age. Xenobiotics are frequently involved in drowning cases but their influence on the diagnosis of fatal drowning has not been studied so far. This preliminary study aimed to assess the influence of an alcohol and/or a drug intoxication on the autopsy signs of drowning, and on the results of diatom analyses in drowning deaths. Twenty-eight autopsy cases of drowning including 19 freshwater drownings, 6 seawater drownings, and 3 brackish water drownings were prospectively included. Toxicological and diatom tests were performed in each case. The influence of alcohol and other xenobiotics on drowning signs and diatom analyses was assessed separately then in combination through a global toxicological participation score (GTPS). Diatom analyses showed positive results in lung tissue in every case. No significant association was found between the degree of intoxication and the diatom concentration in the organs, even after considering freshwater drowning cases only. The vast majority of the traditional autopsy signs of drowning were not significantly affected by the individual toxicological status either, with the exception of lung weight which tended to raise in case of intoxication, probably due to the pulmonary edema and congestion increase. Further research on larger autopsy samples is needed to confirm the results of this exploratory study.
Incidence and treatment approach of intraocular pressure elevation after various types of local steroids for retinal diseases
Authors: Wykrota Agata Anna , Abdin Alaa Din , Munteanu Cristian , Löw Ursula , Seitz Berthold 
Published: July 2023

Abstract
Purpose
For the treatment of macular edema, in addition to the use of antivascular endothelial growth factors, steroids are also used intravitreally and sub-Tenon. Side effects include among others cataract formation and elevation of intraocular pressure (IOP). The aim of this retrospective study was to elicit the IOP elevation after administration of various steroidal medication, the time of onset, and the efficacy of the administered IOP-lowering therapies.

Methods
We included 428 eyes with a postoperative (n = 136), diabetic (n = 148), uveitic macular edema (n = 61), and macular edema after retinal vein occlusion (n = 83). These patients were treated with one or more diverse steroidal agents once or multiple times. These drugs included: triamcinolone acetonide (TMC) as intravitreal injection (TMC IVI) or sub-Tenon (TMC ST), as well as dexamethasone (DXM) and fluocinolone acetonide (FA) intravitreally. An increase of IOP of ≥ 25 mmHg was designated as pathological. A steroid response in anamnesis, the time of onset of IOP rise from the first administration, and the therapy administered were documented.

Results
Of 428 eyes, 168 eyes (39.3%) had IOP elevation up to a mean of 29.7 (SD ± 5.6) mmHg, which occurred at a median of 5.5 months. Steroids most frequently leading to rise of IOP included DXM (39.1% of all eyes receiving that drug), TMC IVI (47.6%), TMC ST combined with DXM (51.5%), DXM with FA (56.8%), and TMC IVI with DXM (57.4%). A Kaplan–Meier analysis and the Log Rank test showed a significant difference (p < 0.001). IOP rise was treated as follows: 119 conservatively (70.8%), and 21 surgically (12.5%, cyclophotocoagulation 8.3%, filtering surgery 1.8%, in 4 the steroidal drug implant was removed 2.4%), and 28 eyes received no therapy (16.7%). Sufficient IOP regulation was achieved in 82 eyes (68.9%) with topical therapy. In 37 eyes (31.1%) with persistently elevated intraocular pressure, topical therapy had to be continued over the follow-up of 20 ± 7 months.

Conclusions
IOP increases after any type of steroid application are not rare. Results of our study let us suspect that especially therapy with intravitreal dexamethasone, either as a monotherapy or in combination with another steroid, tends to increase IOP more than other steroids. Regular IOP checks are necessary after each steroid administration, with possible initiation of long-term conservative and/or surgical therapy if necessary.
CSPG4 as a target for the specific killing of triple-negative breast cancer cells by a recombinant SNAP-tag-based antibody-auristatin F drug conjugate
Authors: Mungra Neelakshi , Biteghe Fleury A. N. , Malindi Zaria , Huysamen Allan M. , Karaan Maryam , Hardcastle Natasha S. , Bunjun Rubina , Chetty Shivan , Naran Krupa , Lang Dirk , Richter Wolfgang , Hunter Roger , Barth Stefan 
Published: July 2023

Abstract
Purpose
Triple-negative breast cancer (TNBC) is phenotypic of breast tumors lacking expression of the estrogen receptor (ER), the progesterone receptor (PgR), and the human epidermal growth factor receptor 2 (HER2). The paucity of well-defined molecular targets in TNBC, coupled with the increasing burden of breast cancer-related mortality, emphasizes the need to develop targeted diagnostics and therapeutics. While antibody–drug conjugates (ADCs) have emerged as revolutionary tools in the selective delivery of drugs to malignant cells, their widespread clinical use has been hampered by traditional strategies which often give rise to heterogeneous mixtures of ADC products.

Methods
Utilizing SNAP-tag technology as a cutting-edge site-specific conjugation method, a chondroitin sulfate proteoglycan 4 (CSPG4)-targeting ADC was engineered, encompassing a single-chain antibody fragment (scFv) conjugated to auristatin F (AURIF) via a click chemistry strategy.

Results
After showcasing the self-labeling potential of the SNAP-tag component, surface binding and internalization of the fluorescently labeled product were demonstrated on CSPG4-positive TNBC cell lines through confocal microscopy and flow cytometry. The cell-killing ability of the novel AURIF-based recombinant ADC was illustrated by the induction of a 50% reduction in cell viability at nanomolar to micromolar concentrations on target cell lines.

Conclusion
This research underscores the applicability of SNAP-tag in the unambiguous generation of homogeneous and pharmaceutically relevant immunoconjugates that could potentially be instrumental in the management of a daunting disease like TNBC.
Effect of differences in O-RADS lexicon interpretation between senior and junior sonologists on O-RADS classification and diagnostic performance
Authors: Yang Ya , Wang Hongyan , Liu Zhenzhen , Su Na , Gao Luying , Tao Xixi , Zhang Rui , Gu Yang , Ma Li , Wang Ruojiao , Xu Wen , Xie Yuhuan , Zhang Wenjun , Zhang Heng , Xue Gaiqin , Ru Tong , Dai Qing , Li Jianchu , Jiang Yuxin 
Published: July 2023

Abstract
Purpose
To assess the consistency of Ovarian-Adnexal Reporting and Data System (O-RADS) lexicon interpretation between senior and junior sonologists and to investigate its impact on O-RADS classification and diagnostic performance.

Methods
We prospectively studied 620 patients with adnexal lesions, all of whom underwent transvaginal or transrectal ultrasound performed by a senior sonologist (R1) who selected the O-RADS lexicon description and O-RADS category for the lesion after the examination. Meanwhile, the junior sonologist (R2) analyzed the images retained by R1 and divided the lesion in the same way. Pathological findings were used as a reference standard. kappa (к) statistics were used to assess the interobserver agreement.

Results
Of the 620 adnexal lesions, 532 were benign and 88 were malignant. When using the O-RADS lexicon, R1 and R2 had almost perfect agreement regarding lesion category, external contour of solid lesions, presence of papillary inside cystic lesions, and fluid echogenicity (к: 0.81–1.00). Substantial agreement in solid components, acoustic shadow, vascularity and O-RADS categories (к: 0.61–0.80). Consistency in classifying classic benign lesions in the O-RADS category was only moderate (к = 0.535). No significant difference in diagnostic performance between them using O-RADS (P = 0.1211).

Conclusion
There was good agreement between senior and junior sonologists in the interpretation of the O-RADS lexicon and in the classification of O-RADS, except for a moderate agreement in the interpretation and classification of classic benign lesions. Differences in O-RADS category delineation between sonologists had no significant effect on the diagnostic performance of O-RADS.
The effect of spanning external fixation on entrapped structures in tibial pilon fractures
Authors: Thomas Sean , Huang Brady K. , Korrapati Avinaash , O’Leary Brendan , Gurusamy Pradyumna , O’Leary Ryan , Kent William T. 
Published: July 2023

Abstract
Purpose
Pilon fractures are often complex injuries involving severe soft tissue injury. Studies have shown pilon fractures may entrap soft tissue structures between fracture fragments. Staged fixation of pilon fractures with spanning external fixation (SEF) is important for soft tissue rest and plays an important role in the management of these injuries. While SEF has been shown to promote soft tissue rest prior to definitive fixation, no studies have shown the effect SEF has on entrapped structures (ES). The purpose of this study was to evaluate how SEF effects ES in pilon fractures.

Methods
A retrospective review of 212 pilon fractures treated at our institution between 2010 and 2022 was performed. Patients with a CT scan pre-SEF and post-SEF met inclusion criteria. CTs were reviewed to characterize ES in pre- and post-SEF imaging.

Results
Of the 19 patients with ES identified on CT pre-SEF, seven (36.8%) had full release of ES post-SEF and 12 (63.2%) had no release of ES. The posterior tibial tendon was the most commonly ES and remained entrapped in 62.5% of cases. Only 25% of 43-C3 fractures had release of ES post-SEF, while 100% of 43-C1 and 43-C2 fractures demonstrated complete release of ES post-SEF.

Conclusion
Entrapped structures in pilon fractures are likely to remain entrapped post-SEF, with only one-third of our cohort demonstrating release. In 43-C3 patterns, if ES are identified on CT pre-SEF, surgeons should consider addressing these either through mini open versus open approaches at the time of SEF as they are likely to remain entrapped post-SEF.
Performance Evaluation of AE Sensors Installed Like Hydrophones in Adaptive Monitoring Networks During a Decametre-Scale Hydraulic Stimulation Experiment
Authors: Boese Carolin M. , Kwiatek Grzegorz , Plenkers Katrin , Fischer Thomas , Dresen Georg 
Published: July 2023

AbstractIn the framework of the STIMTEC and STIMTEC-X hydraulic stimulation experiments at the Reiche Zeche mine, Freiberg (Germany), we installed acoustic emission (AE) sensors for the recording of picoseismicity both conventionally using pneumatic coupling and experimentally like a hydrophone, i.e. the sensors were placed in the borehole without a further coupling system or cementing. We investigate performance measures of the hydrophone-like acoustic emission (HAE) sensors such as frequency bandwidth, sensitivity, first motion polarity, coupling and placement quality to assess the sensor’s applicability in adaptive monitoring networks. HAE sensors can be paired with hydraulic equipment, especially with the double packer probe used for stimulation at the decametre scale because the monitored frequency content differs from injection-related noise. This offers a unique opportunity to improve the network geometry and consequently the quality of a seismic catalogue. We analyse the sensor characteristics using active ultrasonic transmission measurements from boreholes with different orientations in the rock volume, noise measurements preceding active centre punch hits in the access galleries and passive recordings of induced acoustic emission events. HAE sensors placed in water-filled boreholes show good sensitivity performance even without optimal coupling to the crystalline rock for recording distances up to 17 m. The HAE sensors record the wavefield adequately for first-arrival identification, polarity picking and amplitude characteristics but are less suitable for detecting S-waves. Due to the borehole geometry HAE sensors record waves with incidence angles from the side, resulting in opposite polarity compared to side-view AE sensors as observed in the field and lab. We discuss the advantages of adaptive monitoring networks with HAE sensors being optimally placed for each stimulation interval configuration anew to improve seismic event detection and quality of event hypocentre locations during hydraulic stimulations. We show that we are able to significantly reduce the azimuthal gap, halve the location uncertainties and improve the network coverage for the purpose of focal mechanism estimations.
The role of prior knowledge and need for cognition for the effectiveness of interleaved and blocked practice
Authors: Nemeth Lea , Lipowsky Frank 
Published: July 2023

AbstractInterleaved practice combined with comparison prompts can better foster students’ adaptive use of subtraction strategies compared to blocked practice. It has not been previously investigated whether all students benefit equally from these teaching approaches. While interleaving subtraction tasks prompts students’ attention to the different task characteristics triggering the use of specific subtraction strategies, blocked practice does not support students in detecting these differences. Thus, low-prior-knowledge students would benefit from interleaving rather than blocking as it guides them through the learning-relevant comparison processes. Because these comparison processes are cognitively demanding, students’ need for cognition (NFC) could influence the effectiveness of interleaved practice. The present study investigates the role of students’ prior knowledge and NFC for the effectiveness of interleaved and blocked practice. To this end, 236 German third-graders were randomly assigned to either an interleaved or blocked condition. Over 14 lessons, both groups were taught to use four number-based strategies and the written algorithm for solving subtraction problems. The interleaved learners were prompted to compare the strategies, while the blocked learners compared the adaptivity of one strategy for different mathematical tasks. A quadratic growth curve model showed that prior knowledge had a positive influence on students’ development of adaptivity in the blocked but not in the interleaved condition. Students’ NFC had a positive impact in the interleaved condition, while it had no influence in the blocked condition. However, the effects of prior knowledge and NFC did not differ significantly between the two conditions.