bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poor Glycemic Control and its Determinants in Patients with Type 2 Diabetes Mellitus Taking Treatment at an Urban Health and Training Center in Goa: A Cross-Sectional Study
Authors: Mascarenhas e Dias Nadia Claire , Kamble Vishakha Uday , Cacodcar Jagadish Anil 
Published: January 2025

ABSTRACT

Background:
National Family Health Survey 5 (2019–2021) reported an increased random blood sugar level among 37% of Goans. According to the recent ICMR-INDIAB study, Goa had the highest prevalence of diabetes in India (26.4%).

Aim and Objectives:
To assess glycemic control and identify the determinants of poor glycemic control in patients with type 2 diabetes mellitus (T2DM) taking treatment at an urban health and training center in St Cruz.

Methods:
A cross-sectional study was conducted over a period of 3 months among 225 T2DM patients taking treatment for at least 5 years. Simple random sampling was used to select the participants. A semi-structured questionnaire was used to collect data, and HbA1c levels done within the last 3 months were used to determine glycemic control.

Results:
52.4% of the participants had poor glycemic control. Determinants such as treatment with insulin (OR = 0.241, P = 0.000), not on hypertensive medication (OR = 0.458, P = 0.023), being married (OR = 1.832, P = 0.037), being employed (OR = 0.298, P = 0.019), and self-monitoring of blood glucose (OR = 0.502, P = 0.018) were found to be significantly associated with poor glycemic control.

Conclusion:
Over half the study participants had poor glycemic control. Treatment with insulin and being employed were the most common determinants of poor glycemic control.
Effect of Artesunate on Behavioral Functions in Experimental Model of Alzheimer’s Disease
Authors: Pattanayak Chaitali , Patanaik Sunil Kumar , Srivastava Vartika , Das Mangala Charana , Sarkar Sougata 
Published: January 2025

ABSTRACT

Introduction:
Alzheimer’s disease (AD) is a common form of dementia, causing loss of memory and cognitive impairment because of progressive neurodegeneration. Current treatment modalities for AD do not cure the disease completely, are expensive, and are associated with numerous adverse effects. Artesunate is a semisynthetic product of artemisinin, derived from the plant Artemisia annua and used conventionally to fight malaria for a long time in Chinese medicine. Artesunate is a multipotent agent with a wide array of actions.

Methodology:
The study was conducted in the animal house of the Department of Pharmacology, KIMS, Bhubaneswar, after getting approval from the Institutional Animal Ethics Committee. A total of 36 albino Wistar rats weighing 150–200 gms were selected for the study and divided into six groups containing six rats each. Group I was the normal control, and rats received only normal saline and regular food, whereas group II rats were disease control and received aluminum chloride only. Group III rats were the standard control group and received donepezil hydrochloride along with aluminum chloride, whereas groups IV, V, and VI were the test treatment control group receiving graded doses of artesunate along with aluminum chloride. The behavioral parameters were assessed through the morris water maze, elevated plus maze, actophotometer, and passive avoidance tests.

Results:
Artesunate treatment group showed considerable improvement in behavioral functions, and this effect was comparable with a standard group at the highest selected dose.

Conclusion:
Artesunate demonstrated neuroprotective effects through various possible mechanisms. Hence, artesunate might be therapeutically useful in neurogenerative disorders.
Do We Need to Act Fast in Central Serous Chorioretinopathy? - A Comparative Study
Authors: Pandey Jayati , Tripathi Anchal , Pathak Lav , Khan Perwez , Khan Lubna 
Published: January 2025

ABSTRACT

Background:
Central serous chorioretinopathy (CSCR) is a sporadic disorder of the outer blood-retinal barrier, characterized by a localized detachment of the sensory retina usually affecting one eye in young males. Usually, a self-limiting disease various treatments have been investigated in recent times.

Aim:
To evaluate the final visual outcome, recurrence rate, and possible complications in patients of CSCR treated with observation, oral acetazolamide, oral eplerenone, and double-frequency neodynium-doped yttrium aluminium garnet (ND-YAG) laser photocoagulation.

Methods:
A prospective interventional study was conducted on patients newly diagnosed with CSCR. The patients were divided into four groups namely: Group A on observation, Group B on oral acetazolamide Group C on oral eplerenone, and Group D on Double frequency Nd-YAG laser. The visual recovery, recurrence rate, and possible complications of these therapies were compared.

Results:
The study comprised of 76 patients. Group D patients showed the fastest improvement in visual acuity at 2 weeks. At 12 weeks, all groups had comparable improvement. Three patients in Group A, 1 each in Groups B and D, and 2 in Group C showed recurrence. Paresthesia, numbness, and gastric upset related to acetazolamide were noted in 5 patients of Group B. However, 16.7% of cases in Group A, 10.5% in Group B, 5.3% in Group C, and 5% in Group D showed leakage on Fundus fluorescent angiography after 12 weeks.

Conclusion:
In acute CSCR eplerenone seems to be efficient with the least side effects and early resolution. In chronic cases, Double frequency Nd-YAG laser seems to give better results. Early treatment should be given for better visual recovery of patients.
Aberrant Expression of CD Markers in Acute Leukemia with Hematological Parameters Correlation: A Single Center Experience
Authors: Sharma Monika , Dixit Nutan , Bansal Taruna , Kumar Vijay , Jyoti Sai 
Published: January 2025

ABSTRACT

Background:
Immunophenotyping by flowcytometry improves both the accuracy and reproducibility of an acute leukemia (AL) diagnosis. The morphologically similar blast cells can be easily differentiated by immunophenotyping based on expression and different CD (cluster of differentiation) markers. It also plays a crucial role in the identification of aberrant antigens. The present study was conducted to determine the frequency of aberrant phenotypes in newly diagnosed cases of acute leukemia and its correlation with hematological parameters.

Methods:
We retrospectively investigated the phenotype of blast cells from 72 patients with acute leukemia diagnosed over a one and half year period. Diagnosis of acute leukemia was based on morphology, cytochemistry, and immunophenotyping by flow cytometry.

Results:
Out of the total 72 cases of Acute leukemia, 40 (55.6%) cases showed aberrant expression. 12/27 cases (44.4%) of AML and 28/45 cases (62.2%) of ALL showed aberrant phenotypes in the present study. Aberrant expression of CD7, 6/27 cases (22.2%) was very frequent in AML. Among the ALL cases, CD13, 14/45 cases (31.1%) were most commonly expressed. The mean total leukocyte count (TLC) and percentage of blasts in peripheral blood were significantly higher in AML and ALL cases with aberrant phenotypes as compared to their conventional phenotypes with no aberrancy.

Conclusions:
It is of clinical importance to detect aberrant phenotypes for accurate diagnosis and when looking for minimal residual disease during morphologic remission. In addition, aberrant phenotypes in AML and ALL cases are associated with unfavorable hematological features in our study.
Astragalus-Zedoary Inhibits Epithelial–Mesenchymal Transition in Colorectal Cancer MC38 Cell Xenograft Mice to Promote Oxaliplatin Attenuation and Sensitization
Authors: Liu Lei , Lei Ting , Jiang Hua , Qu Wen-Ze , Xiao Meng-Yuan , Zhang Jin-Yue , Guo Yan-Mei , Zhu Jia , Zhang Ming-Xia , Zhang Ying 
Published: January 2025

Objective:
The purpose of this study was to verify the sensitizing and toxicity-alleviating effects of Astragalus-zedoary on oxaliplatin chemotherapy for colorectal cancer (CRC).

Materials and Methods:
MC38 tumor-bearing mice were randomly divided into three groups and treated with oxaliplatin or Astragalus-zedoary combined with oxaliplatin. The general physical status, changes in body weight, and tumor weight of the mice were recorded. Pathological morphology of the tumor was detected by hematoxylin and eosin staining, apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling, and epithelial–mesenchymal transition (EMT) and drug resistance-related factors were detected by immunohistochemistry, western blotting, and real-time polymerase chain reaction.

Results:
The experimental results showed that compared with oxaliplatin alone, mice in the combination group had higher body weight and mental state, shinier hair, reduced tumor weight, increased tumor inhibition and apoptosis rates, upregulated expression of E-cadherin protein and mRNA, and downregulated expression of N-cadherin, multidrug resistance-associated protein 1 (MRP1), and P-glycoprotein. It was confirmed that the combination of Astragalus-zedoary and oxaliplatin had a synergistic tumor inhibition effect, with a good ability to interfere with the EMT process of CRC tumor cells, inhibit the transporter, and increase the sensitivity of tumor cells to oxaliplatin.

Conclusions:
Astragalus-zedoary exhibits an enhanced antitumor effect and can play a synergistic role with oxaliplatin chemotherapy, thereby significantly enhancing the long-term survival rate and quality of life of tumor-bearing mice.
¿Extorsión, un laberinto sin salida?: Modalidades más empleadas en Alto Trujillo
Authors: Leiva felipe María Fernanda , Medrano Polo Evelin Yuliana 
Published: January 2025

La presente investigación tuvo como objetivo determinar en qué medida el delito de extorsión incide en la inseguridad ciudadana en los habitantes del Distrito de Alto Trujillo- 2022; se trata de un estudio de tipo cualitativo, diseño no experimental del nivel descriptivo explicativo, método de estudio inductivo, la muestra estuvo conformada por cuatro profesionales. El instrumento empleado fue la guía de entrevista. Los resultados fueron que la modalidad más utilizada actualmente y que genera mayor violencia en los pobladores del Alto Trujillo es el cobro de cupos, para garantizar la seguridad de las víctimas en el delito de extorsión es la implementación de agentes policiales especializados que ayudan aresguardar la vida e intereses de la víctima, no se señala estrategias específicas para desincentivar financieramente a los perpetradores, llegándose a la conclusión de que solo se recurre a la ayuda de agentes policiales, la modalidad más utilizada y genera mayor ventaja económica en los pobladores de Alto Trujillo es la extorsión agravada, los grupos o sectores que tienen mayor grado de amenaza frente el delito de extorsión son aquellos micro pequeños empresarios, los familiares de las víctimas de este delito son las que se ven afectadas ya que estas son tomadas como rehén a cambio de una suma de dinero , que las medidas que actualmente son implementadas en el Distrito de Alto Trujillo no son totalmente eficaces para combatir el delito de extorsión, ya que se es necesario aun que se cuente con más efectivos y vehículos policiales en diversas zonas.
Coping Strategies of Social Protection Programs for Community Resilience to Climate Shocks in Tana North Sub-County, Tana River County, Kenya
Authors: Ikumu Lucy Wangui , Kathambi Bessy , Kiemo Karatu 
Published: January 2025

This study examines the effectiveness of coping strategies of social protection programs in enhancing community resilience to climate shocks in Tana North Sub-County, Tana River County, Kenya. Despite its potential as a policy response, the effectiveness of social protection as a coping strategy in fostering community resilience remains underexplored. This study explores coping strategies employed by local communities and analyses the role of social protection interventions in migrating the impacts of climate-related disasters. Using a mix of qualitative and quantitative methods data was collected from 362 respondents, including surveys, interviews, and focus groups. The research finds that while these programs provide essential immediate relief and improve absorptive capacities, their impact on adaptation and long-term resilience is limited. Challenges such as inadequate coverage, irregular support, and poor integration with broader resilience-building efforts hinder their effectiveness and restrict their ability to foster community resilience to shocks. The study underscores the urgent need to identify best practices and inform policy recommendations for improving adaptation and fostering community resilience to climate shocks in the region.
Impact of Burnout on Job Psychological Motivation among Correctional Prison Officers in Kenya
Authors: Julie Nabwire Christine , Okoth George Samuel 
Published: January 2025

Purpose: The reported research sought to examine burnout affects the psychological motivation of correctional officers in their job. Scholars on burnout and psychological work motivation have conducted a significant amount of research. However, only a few studies have investigated the link between burnout and psychological work motivation among these individuals in Kenya. The study was to assess the impact of burnout on job psychological motivation among correctional officers working in six Medium Prisons within Nyanza Region of Kenya.
Methodology: This study employed a descriptive and correlational research design utilizing a survey method. The study incorporated both quantitative and qualitative approaches and was guided by the principles of Rational Emotive Behaviour Theory and Solution Focused Theory. The target population was 1,910 prison officers attached to six Medium prisons in Nyanza region of Kenya. The prison facilities included Kisumu Medium Prison in Kisumu County, Nyamira Prison in Nyamira County, Migori Prison in Migori County, Siaya Prison in Siaya County, Kisii Main Prison in Kisii County and Homa Bay Prison in Homa Bay County. The researcher categorized correctional officers into various types of ranks, such as gazetted officers, inspectorate officers, non-commissioned officers, and constables. In this study, the research employed the Maslach Burnout Inventory- Human Services Survey (MBI-HSS) and the Multidimensional Work Motivation Scale (MWMS) as instruments for measurement.
Findings: The researcher realized that within the medium prisons, officers who are deployed to work directly with the inmates are male officers whereas the female officers are deployed to work in the offices hence the sample population was totally men. It also came out that there was no difference in the responses from different facilities and therefore the findings were handled generally. The research discovered that burnout has a significantly detrimental effect on the psychological motivation of correctional officers, with a correlation coefficient, r = - 0.768; Sig. = 0.025.
Unique Contribution to Theory, Policy and Practice: The research suggests that it would be beneficial for prison management to employ trained counselors and establish effective systems for addressing burnout among correctional officers. Additionally, they should implement methods for increasing the job motivation and psychological well-being of the officers.
Impact of Different Household Cooking Methods on the Nutritional Composition, Total Phenolic Content and Invitro Antioxidant Activities of African nightshade (Solanum scabrum) and Vegetable amaranth (Amaranthus hybridis)
Authors: Njong Clementine Endam , Manga Gilbert Ghislain Mbassi , Sonchieu Jean , Ejoh Richard Aba 
Published: January 2025

Purpose: The objective of this study was to subject African nightshade and vegetable Amaranth to different household cooking methods (boiling, steaming, microwave and stir frying) and test them on the changes of total phenolic content (TPC), antioxidant property (ferric reducing-antioxidant power (FRAP) activity and DPPH radical scavenging activity), macronutrients and micronutrients.
Methodology: The African nightshade, (HB) and the Amaranthus leaves, (AL) used in the preparation of all the dishes were purchased from the same farmer at Nkwen in Mezam division of the North West Region of Cameroon. Standard methods were used to determine each analyte at the Laboratory of Food Science and Metabolism (LabSAM) of the University of Yaounde 1 and Nkolbisson Food Technology Laboratory, Yaounde, Cameroon.
Findings: The TPC of leafy vegetables ranged from 256.64 to 1184.08 mg GAE/100g, with higher levels observed in cooked forms compared to raw ones. Steaming significantly increased FRAP in both African nightshade and amaranth, followed by microwaving and boiling, with steamed samples showing the highest antioxidant activity. Cooking methods also enhanced DPPH free radical scavenging activity, with microwaved African nightshade (HBM) and steamed amaranth (ALS) exhibiting the highest activity. Nutritional analysis revealed variations in dry matter, ash, protein, crude fiber, and total sugars, with steamed vegetables (ALS, HBM, HBS) generally having higher nutrient levels. Mineral and vitamin analyses showed iron (19.08–34.87 mg/100g DW), zinc (1.06–3.92 mg/100g DW), vitamin C (93.85–231.42 mg/100g DW), and provitamin A (16.5–62.85 mg/100g DW) levels were higher in cooked vegetables compared to their raw counterparts.
Unique contribution to theory, practice and policy:
This study demonstrates that different cooking techniques impact the nutritional composition and antioxidant activities of the indigenous vegetables; African nightshade and vegetable amaranth. The findings provide valuable insights for optimizing the cooking methods of these vegetables to enhance their health benefits. Thus this study greatly contributes to providing healthy choices on the different ways in which these vegetables can be cooked.
El Principio de Íntegra Regularización obliga a proyectar en los ejercicios no prescritos y objeto de regularización las consecuencias también favorables que resulten de comprobaciones de ejercicios prescritos: STS de 7 de junio de 2024, rec. Núm. 7974/20
Authors: Arrieta Martínez de Pisón Juan 
Published: January 2025

El principio de íntegra regularización es el que obliga y hace jurídicamente posible que se proyecten sobre ejercicios no prescritos y que están siendo objeto de regularización, los datos, apreciaciones y conclusiones que, con dimensión jurídica y económica, haya obtenido la Administración tributaria al comprobar los ejercicios prescritos en el ejercicio de su potestad de comprobación e investigación, y ello con independencia de que resulten favorables o desfavorables para el contribuyente.
Análisis y propuestas sobre las medidas fiscales estatales y autonómicas a raíz de las inundaciones en la Comunidad Valenciana
Authors: Uriol Egido Carmen 
Published: January 2025

En este estudio se realiza un análisis detallado y crítico de las medidas fiscales aprobadas por el Estado y las Comunidades Autónomas para dar una respuesta inmediata a los importantes daños personales y materiales provocados por el temporal de lluvia que se produjo el 29 de octubre de 2024 en diferentes partes del territorio español, afectando de manera especial a numerosos municipios de la Comunidad Valenciana. Y se realizan una serie de propuestas normativas en materia tributaria que contribuyan a la efectiva recuperación de los territorios afectados.
La consideración de operaciones vinculadas y su sometimiento a valoración de mercado de determinadas retribuciones obtenidas por los administradores de entidades mercantiles: RTEAC de 24 de septiembre de 2024, rg. 1354/2023
Authors: Pérez Pombo Emilio V. 
Published: January 2025

La doctrina administrativa del Tribunal Económico-Administrativo Central tras la Resolución en unificación de criterio de 24 de septiembre de 2024 y su precedente de 20 de marzo de 2024, establece que, en aquellos casos en que una persona física, ostente el cargo de administrador de una sociedad y, a su vez, sea designado por esta última como representante persona física en el órgano de administración de una tercera, estaríamos ante un doble vínculo, con naturalezas jurídicas y regímenes de valoración diferenciados.
La reserva de nivelación de bases imponibles negativas del art.105 de la Ley del Impuesto sobre Sociedades
Authors: Alonso Madrigal Javier 
Published: January 2025

El artículo examina críticamente el ámbito de aplicación de la reserva de nivelación de bases imponibles negativas para empresas de reducida dimensión en el IS y cuantifica su importe en términos financieros, el límite al incentivo y su articulación con la reserva de capitalización y concluye con unas propuestas de lege ferenda.
La no sujeción al Impuesto sobre el Valor Añadido de los servicios prestados por administradores y consejeros de sociedades mercantiles con independencia de su condición de persona física o jurídica
Authors: Almudí Cid José Manuel 
Published: January 2025

La sujeción al IVA de los servicios prestados en la condición de administrador o miembro del consejo de administración de una sociedad mercantil siempre ha resultado una cuestión controvertida y, de hecho, desde la óptica de la imposición indirecta, dista mucho de poder considerarse homogéneo el tratamiento que, a esta relación jurídica, se le ha venido otorgando por los distintos países miembros de la Unión Europea.
El artículo 89.2 de la LIS como paradigma de la inseguridad jurídica que rige las operaciones de reestructuración empresarial: RRTEAC de 22 de abril de 2024 (6448/2022 y 6452/2022) y 27 de mayo de 2024 (6513/2022 y 6550/2022)
Authors: Marín Benítez Gloria 
Published: January 2025

El TEAC se pronuncia sobre la aplicación del artículo 89.2 de la LIS a la aportación no dineraria de participaciones en una sociedad activa a una holding. Negando en el caso la existencia de otra motivación que la de aplicar el artículo 21 de la LIS a los dividendos que en el futuro percibirá la holding, entiende que esa ventaja fiscal es abusiva en la parte que corresponde a las reservas de la sociedad activa generadas antes de la aportación. Afirma también, corrigiendo la doctrina de la DGT, que para la corrección del abuso se podrá denegar al socio el beneficio del diferimiento inherente al régimen de neutralidad fiscal haciendo tributar la parte de la ganancia que corresponda a esas reservas previas a medida que la holding vaya recibiendo los dividendos e introduciendo los ajustes correspondientes para evitar sobreimposición. Las resoluciones, que pretenden que la aplicación del precepto al caso sea respetuosa con el principio de proporcionalidad, introducen una enorme inseguridad sobre las consecuencias de aplicar la cláusula.
Tratamiento fiscal del Private Equity extranjero para sus partícipes residentes en España. ¿para qué sirve el artículo 95 LIRPF?
Authors: Velayos Jiménez Fernando 
Published: January 2025

Se analiza la problemática fiscal ligada a inversiones del tipo private equity, realizadas en el extranjero tanto por personas físicas como jurídicas residentes en España; materia sobre la cual no existe apenas doctrina (ni administrativa ni académica) ni jurisprudencia. Se profundiza, en particular, sobre la posible aplicación del artículo 95 de la Ley del Impuesto sobre la Renta, en teoría específicamente previsto para Instituciones de Inversión Colectiva constituidas en paraísos fiscales, pero se concluye que su utilización se vuelve ilógica si estas últimas entidades están dedicadas a private equity. Todo lo cual se acompaña de un ejemplo para mejor comprensión.