bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mit sichtbarem Licht geförderte schaltbare selektive Oxidationen von Styrol über kovalente Triazin‐Gerüste in Wasser
Authors: Ayed Cyrine , Yin Jie , Landfester Katharina , Zhang Kai. A. I. 
Published: January 2023

AbstractDie Nutzung der photokatalytischen Oxidation zur Umwandlung von Basischemikalien in hochwertige Verbindungen in umweltfreundlichen Reaktionsmedien ist ein aktueller Schwerpunkt der katalytischen Forschung. Dabei besteht die Herausforderung darin, Kontrolle über die Selektivität der Produktbildung zu erlangen. In der hier vorgestellten Arbeit entwickeln wir kovalente Triazin‐Gerüste als heterogene, metallfreie und recycelbare Photokatalysatoren für die durch sichtbares Licht angetriebene selektive Oxidation von Styrol in reinem Wasser. Die Selektivität der Produktbildung wurde durch Aktivierung oder Deaktivierung der spezifischen photogenerierten Sauerstoffspezies erreicht. Unter Verwendung desselben Photokatalysators konnte Benzaldehyd durch Deaktivierung von photogeneriertem H2O2mit über 99 % Umsatz und über 99 % Selektivität als Einzelprodukt gewonnen werden. Die äußerst anspruchsvolle und empfindliche Epoxidierungsreaktion von Styrol wurde durch die Bildung von Peroxymonocarbonat als anfängliches Epoxidierungsmittel in Gegenwart von Bicarbonat durchgeführt, was zur Bildung von Styroloxid mit einer Selektivität von bis zu 76 % bei nahezu quantitativer Umsetzung führte. Diese Studie stellt ein vorläufiges, aber dennoch interessantes Beispiel für die einfache Kontrolle über schaltbare Selektivität der Produktbildung bei anspruchsvollen Oxidationsreaktionen von organischen Verbindungen in reinem Wasser dar.
Amplification of Lipid Peroxidation by Regulating Cell Membrane Unsaturation To Enhance Chemodynamic Therapy
Authors: Zhu Yang , Gong Peng , Wang Jun , Cheng Junjie , Wang Wenyu , Cai Huilan , Ao Rujiang , Huang Hongwei , Yu Meili , Lin Lisen , Chen Xiaoyuan 
Published: January 2023

AbstractLipid peroxidation (LPO) is one of the most damaging processes in chemodynamic therapy (CDT). Although it is well known that polyunsaturated fatty acids (PUFAs) are much more susceptible than saturated or monounsaturated ones to LPO, there is no study exploring the effect of cell membrane unsaturation degree on CDT. Here, we report a self‐reinforcing CDT agent (denoted as OA@Fe‐SAC@EM NPs), consisting of oleanolic acid (OA)‐loaded iron single‐atom catalyst (Fe‐SAC)‐embedded hollow carbon nanospheres encapsulated by an erythrocyte membrane (EM), which promotes LPO to improve chemodynamic efficacy via modulating the degree of membrane unsaturation. Upon uptake of OA@Fe‐SAC@EM NPs by cancer cells, Fe‐SAC‐catalyzed conversion of endogenous hydrogen peroxide into hydroxyl radicals, in addition to initiating the chemodynamic therapeutic process, causes the dissociation of the EM shell and the ensuing release of OA that can enrich cellular membranes with PUFAs, enabling LPO amplification‐enhanced CDT.
Efficient adsorption of trinitrotoluene by isoxazoline‐based porous polymers prepared from room‐temperature stable bis(nitrile oxide)
Authors: Xu Yewei , Yang Chunyan , Deng Hongyang , Zhong Chi , He Peiyu , Zhang Tinghong , Sun Yi , Yuan Rui , Liang Shuen , Kang Biao , Chang Guanjun 
Published: January 2023

AbstractA novel isoxazoline‐based porous adsorbent (PB‐TTNO) is prepared by click polymerization and freeze‐drying from a methyl‐containing bis(nitrile oxide) stable at room temperature. The introduction of four methyl groups around the nitrile oxide group reduces the activity of the bis(nitrile oxide) and make it react more mildly with polybutadiene, resulting in PB‐TTNO with a more uniform pore size. Meanwhile, the electron‐donating methyl groups further increase the π–π interaction between the polymer benzene ring and the TNT benzene ring. The π–π interaction enables one benzene ring in the polymer to interact with two TNT molecules to form a sandwich structure, which further improves the adsorption capacity. The synergistic effect of dual π–π interactions and dipole‐π interactions makes the maximum adsorption capacity of PB‐TTNO reach 235.3 mg g−1 within 12 h at 25°C. The factors such as pH value, adsorbent dosage, contact time, initial TNT concentration, and temperature are also discussed. The adsorption kinetics fit well with the pseudo‐second‐order model, and the Langmuir model exhibits better correlation for equilibrium data analysis. In addition, the adsorption data of PB‐TTNO in real water samples are similar to those in laboratory, and the maximum adsorption capacity decreases by only 15% after five adsorption–desorption cycles.
DNA release from plant tissue using focused ultrasound extraction (FUSE)
Authors: Stettinius Alexia , Holmes Hal , Zhang Qian , Mehochko Isabelle , Winters Misa , Hutchison Ruby , Maxwell Adam , Holliday Jason , Vlaisavljevich Eli 
Published: January 2023

AbstractPremiseSample preparation in genomics is a critical step that is often overlooked in molecular workflows and impacts the success of downstream genetic applications. This study explores the use of a recently developed focused ultrasound extraction (FUSE) technique to enable the rapid release of DNA from plant tissues for genetic analysis.MethodsFUSE generates a dense acoustic cavitation bubble cloud that pulverizes targeted tissue into acellular debris. This technique was applied to leaf samples of American chestnut (Castanea dentata), tulip poplar (Liriodendron tulipifera), red maple (Acer rubrum), and chestnut oak (Quercus montana).ResultsWe observed that FUSE can extract high quantities of DNA in 9–15 min, compared to the 30 min required for control DNA extraction methods. FUSE extracted DNA quantities of 24.33 ± 6.51 ng/mg and 35.32 ± 9.21 ng/mg from American chestnut and red maple, respectively, while control methods yielded 6.22 ± 0.87 ng/mg and 11.51 ± 1.95 ng/mg, respectively. The quality of the DNA released by FUSE allowed for successful amplification and next‐generation sequencing.DiscussionThese results indicate that FUSE can improve DNA extraction efficiency for leaf tissues. Continued development of this technology aims to adapt to field‐deployable systems to increase the cataloging of genetic biodiversity, particularly in low‐resource biodiversity hotspots.
Polarization‐Dependent Optical Forces Arising from Fano Interference
Authors: Zhang Yao , Li Tianyue , Wang Shuming , Wang Zhenlin , Zhu Shining 
Published: January 2023

AbstractA Fano resonance originates from the resonant coupling between interacting multipoles inside nanostructures. It breaks the symmetry of spectral line shape and enables Fano‐resonant media to present unusual scattering properties. However, understanding the mechanical effects of such multipolar coupling systems is highly complex compared with the traditional simple dipole. In this work, using single Si nanospheres as the Fano‐resonant media, optical forces arising from different types of Fano resonances including the electric, magnetic, and magnetoelectric Fano resonances are investigated. It is shown that the directions of these types of forces are tunable in three dimensions. The necessary condition to realize a direction change of the Fano‐resonance‐induced forces and elucidate the underlying physics are presented. Furthermore, it is found that the Fano‐resonance‐induced forces exhibit strong polarization‐dependent properties which traditional optical (dipolar) forces cannot possess.
Classification of multiple sclerosis women with voiding dysfunction using machine learning: Is functional connectivity or structural connectivity a better predictor?
Authors: Tran Khue , Salazar Betsy H. , Boone Timothy B. , Khavari Rose , Karmonik Christof 
Published: January 2023

AbstractIntroductionMachine learning (ML) is an established technique that uses sets of training data to develop algorithms and perform data classification without using human intervention/supervision. This study aims to determine how functional and anatomical brain connectivity (FC and SC) data can be used to classify voiding dysfunction (VD) in female MS patients using ML.MethodsTwenty‐seven ambulatory MS individuals with lower urinary tract dysfunction were recruited and divided into two groups (Group 1: voiders [V, n = 14]; Group 2: VD [n = 13]). All patients underwent concurrent functional MRI/urodynamics testing.ResultsBest‐performing ML algorithms, with highest area under the curve (AUC), were partial least squares (PLS, AUC = 0.86) using FC alone and random forest (RF) when using SC alone (AUC = 0.93) and combined (AUC = 0.96) as inputs. Our results show 10 predictors with the highest AUC values were associated with FC, indicating that although white matter was affected, new connections may have formed to preserve voiding initiation.ConclusionsMS patients with and without VD exhibit distinct brain connectivity patterns when performing a voiding task. Our results demonstrate FC (grey matter) is of higher importance than SC (white matter) for this classification. Knowledge of these centres may help us further phenotype patients to appropriate centrally focused treatments in the future.
Horseshoe kidney: Morphologic features, embryologic and genetic etiologies, and surgical implications
Authors: Humphries Audrey , Speroni Samantha , Eden Kristin , Nolan Michael , Gilbert Carol , McNamara John 
Published: January 2023

AbstractThe horseshoe kidney (HSK) is the most common congenital abnormality of the upper urinary tract with an incidence of approximately 1 in 500 in the general population. Although individuals with HSK are often asymptomatic, they are at increased risk for neoplasms, infections, ureteropelvic obstruction secondary to lithiasis or vascular compression. Direct injury from trauma is increased in these individuals as is the risk of intraoperative complications secondary to damage involving the typically complex renal or adrenal vascular supply.We briefly review etiological factors including renal and urinary system embryology, genetic mutations, abnormalities related to faulty cell signaling, aberrant cell migration, and other possible causes including environmental exposures and trauma. In addition, we call attention to factors that might influence the success of surgical procedures in patients with HSK. We argue that an understanding of possible etiologies of the HSK and its different subtypes may be useful when planning surgical procedures or considering risk–benefit ratios associated with different surgical options.We briefly present the organization of a HSK in a 100‐year‐old male demonstrating an unusual vascular supply discovered during a dissection laboratory session in a medical school anatomy course. We describe the structure of the HSK, the position and relationships of the HSK to other structures within the abdomen, and the associated vascular relationships.
Assessment of the efficacy and tolerability of ruxolitinib for the treatment of myelofibrosis patients in a real‐life setting: An Italian MYNERVA Project
Authors: Coltro Giacomo , Sant'Antonio Emanuela , Palumbo Giuseppe A. , Mannelli Francesco , De Stefano Valerio , Ruggeri Marco , Elli Elena M. , Zanotti Roberta , Borsani Oscar , Bertozzi Irene , Duminuco Andrea , Betti Silvia , Carli Giuseppe , Cavalca Fabrizio , Tanasi Ilaria , Rumi Elisa , Randi Maria L. , Garibaldi Bruno , Loscocco Giuseppe G. , Guglielmelli Paola , Vannucchi Alessandro M. 
Published: January 2023

AbstractBackgroundIncorporating real‐world data in the drug development process allows the improvement of health outcomes by providing better representation of actual patterns of drug safety and efficacy.Aims and MethodsHere, we present the results of a retroprospective, observational real‐life study of 154 patients with myelofibrosis treated with ruxolitinib in a real‐life setting in seven Italian centers of the MYNERVA project.ResultsMedian drug exposure was 29 (range, 3–98) months. Discontinuation rate was 27% after a median time of 13 (range, 3–61). While hematological toxicities were in line with previous findings, infections occurred frequently, representing a not negligible cause of discontinuation and death. Anemia, symptoms, and spleen responses were obtained at any time in 23%, 91%, and 68% of patients, respectively; most patients achieved their responses by week 24. Larger splenomegaly and delayed treatment initiation correlated with lower spleen response at 24 weeks. Spleen response was associated with a superior overall survival, regardless of DIPSS. Of interest, both achievement and loss of spleen response had prognostic implications.Discussion and ConclusionOverall, our findings provide insights on the efficacy and safety of ruxolitinib in a real‐world, multicenter cohort of Italian MF patients.
Response to induction chemotherapy predicts survival outcomes in oropharyngeal cancer
Authors: Zhang Qixian , Xu Tingting , Shen Chunying , Qian Wei , Ying Hongmei , He Xiayun , Wang Yu , Ji Qinghai , Hu Chaosu , Zhou Xin , Lu Xueguan 
Published: January 2023

AbstractBackgroundThe role of induction chemotherapy (IC) in oropharyngeal squamous cell carcinoma (OPSCC) remains controversial. Its interpretation can be confounded by heterogeneity in chemosensitivity and human papillomavirus (HPV) status. This study aimed to investigate the prognostic impact of IC response in HPV‐positive and ‐negative OPSCC.MethodsPatients with OPSCC who underwent IC and concurrent chemoradiotherapy (CCRT) were retrospectively analyzed. Radiologic response to IC by ≥50% was defined as IC‐sensitive (IC‐s), while lesser response was deemed as IC‐resistant (IC‐r). Progression‐free survival (PFS) and overall survival (OS) were compared between subgroups.ResultsA total of 51 HPV‐positive and 57 HPV‐negative patients were included. IC‐s patients accounted for 55.6%, 62.7%, and 49.1% in the entire cohort, HPV‐positive, and HPV‐negative subgroup, respectively. Compared with IC‐r subgroup, IC‐s was associated with better clinical outcomes either in the entire cohort (3y‐PFS 91.7%vs.43.7%, P < 0.001; 3y‐OS 98.3% vs. 67.4%, P = 0.002), the HPV‐positive subgroup (3‐year PFS 94.7% vs. 47.9%, P < 0.001; 3‐year OS 100% vs. 73.5%, P = 0.055) or the HPV‐negative subgroup (3‐year PFS 88.2% vs. 40.9%, P = 0.001; 3‐year OS 96.4% vs. 63.1%, P = 0.026). Multivariate analysis demonstrated that response to IC represents an independent prognosticator for 3‐year PFS (HR, 0.088; 95% CI, 0.027–0.289; P < 0.001) and 3‐year OS (HR, 0.100; 95% CI, 0.021–0.477; P = 0.004).ConclusionsResponse to IC exerts a critical predictive effect on prognosis of both HPV‐positive and ‐negative OPSCC. Personalized treatment strategy based on IC response is worthy of further exploration in the future.
The effects of altered DNA damage repair genes on mutational processes and immune cell infiltration in esophageal squamous cell carcinoma
Authors: Yuan Huangbo , Qing Tao , Zhu Sibo , Yang Xiaorong , Wu Weicheng , Xu Kelin , Chen Hui , Jiang Yanfeng , Zhu Chengkai , Yuan Ziyu , Zhang Tiejun , Jin Li , Suo Chen , Lu Ming , Chen Xingdong , Ye Weimin 
Published: January 2023

AbstractBackgroundDefects in DNA damage repair (DDR) pathways lead to genomic instability and oncogenesis. DDR deficiency is prevalent in esophageal squamous cell carcinoma (ESCC), but the effects of DDR alterations on mutational processes and tumor immune microenvironment in ECSS remain unclear.MethodsWhole‐exome and transcriptome sequencing data of 45 ESCC samples from Taizhou, China, were used to identify genomic variations, gene expression modulation in DDR pathways, and the abundance of tumor‐infiltrating immune cells. Ninety‐six ESCC cases from The Cancer Genome Atlas (TCGA) project were used for validation.ResultsA total of 57.8% (26/45) of the cases in the Taizhou data and 70.8% (68/96) of the cases in the TCGA data carried at least one functional impact DDR mutation. Mutations in the DDR pathways were associated with a high tumor mutation burden. Several DDR deficiency‐related mutational signatures were discovered and were associated with immune cell infiltration, including T cells, monocytes, dendritic cells, and mast cells. The expression levels of two DDR genes, HFM1 and NEIL1, were downregulated in ESCC tumor tissues and had an independent effect on the infiltration of mast cells. In the Taizhou data, increased expression of HFM1 was associated with a poor prognosis, and the increased expression of NEIL1 was associated with a good outcome, but no reproducible correlation was observed in the TCGA data.ConclusionThis research demonstrated that DDR alterations could impact mutational processes and immune cell infiltration in ESCC. The suppression of HFM1 and NEIL1 could play a crucial role in ESCC progression and may also serve as prognostic markers.
The COVID‐19 threat and luxury advertising
Authors: Baek Tae Hyun , Kim Jungkeun , Yoon Sukki , Choi Yung Kyun , Taylor Charles R. 
Published: January 2023

AbstractThe purpose of this research is to examine how the COVID‐19 pandemic has impacted the luxury goods industry. The authors hypothesize that pandemic threats drive consumers toward luxury consumption to increase their perceptions of control. The article reports results of three experimental studies conducted in the United States. In Study 1, after participants read an article about COVID‐19, they respond favorably to an advertisement for a luxury brand. The comparative control participants read an article about a tofu dish and respond less favorably to the luxury advertisement. Study 2 provides further evidence that perceived control acts as a mediator, while ruling out alternative explanations. Study 3 indicates that threat evokes luxury preferences only when advertisements for both luxury and nonluxury products use abstract messages, as opposed to concrete messages. The findings provide practical insights showing that the most effective advertising strategy for luxury brand managers is to use abstract rather than concrete messages for targeting consumers who feel highly threatened by COVID‐19.
What makes people hesitant from circularity: An analysis of risk, marketing mix, cost and inconvenience
Authors: Shashi  , Centobelli Piera , Cerchione Roberto , Jhamb Deepika 
Published: January 2023

AbstractThe circular economy (CE) concept has attracted significant research and practical momentum. Nevertheless, knowledge about its relationships to consumption and disposal from consumers' standpoint is still fragmented. Most CE consumer‐centric research ends with a consumer's intention to purchase. As a result, this study intends to fill several research gaps by presenting a framework that goes beyond purchase intention and, consequently, incorporates both actual purchase behaviour and circular disposal, as well as their predictors. We gathered survey data from 489 Indian consumers and the proposed research claims were tested by adopting a structural equation modelling approach. The findings demonstrate that pricing advantage and product quality negatively impact perceived risk and positively impact perceived value. The main results confirm that the perception towards marketing mix plays a significant role in generating positive purchase intention. Furthermore, the indirect influence of the perception towards marketing mix on actual purchase behaviour is stronger than the direct influence. Both actual purchase behaviour and disposal convenience positively impact circular disposal behaviour. Meanwhile, the higher disposal costs discourage customers from circular disposal. This research has important implications for researchers and managers seeking to understand how to foster the circularity rate among consumers.
Young offenders in forensic institutions in the Netherlands after committing serious crimes: Contribution of mandatory treatment and reduction of reincarceration
Authors: Reef Joni , Jeltes Marije , van den Brink Yannick , Brand Eddy 
Published: January 2023

AbstractBackgroundIn the Netherlands, young offenders who have been convicted of a particularly serious offence may be subjected to a so‐called ‘Placement in an Institution for Juveniles’ (PIJ) measure if they are considered to pose a high ongoing risk to public safety. They form a rarely studied distinct group. Treatment in specialist forensic custodial institutions for young people (FYCI) is an intervention of last resort and costly. The most serious young offenders tend to be the hardest to rehabilitate while preventing further offending. Treatment is focussed on reducing risk of harm as well as improving health and other protective factors.AimsTo explore the contribution of treatment in an FYCI under a forensic treatment order—the PIJ‐measure—to the reduction of risk of reoffending.MethodsIn a pre–post intervention study, the Juvenile Forensic Profile (JFP) was used to score complete case files of 178 young offenders at the start and end of their placement in an FYCI under the PIJ‐measure, 59% of those serving between the years 2013 and 2016 inclusive. The JFP covers risk and protective factors in seven domains encompassing criminal behaviour, family, environment, risk factors, psychopathology, psychology and behaviour during incarceration. Change or stability in scores was tested against reincarceration within 2 years of PIJ‐measure completion.ResultsImpulse control and alcohol and drug use problems showed the greatest improvements. Behaviour that deteriorates during the stay is primarily related to obtaining more autonomy during reintegration efforts, including furlough. Reincarceration in the 2 years of community follow‐up was unusual (13.5%). The two main variables associated with reincarceration were problematic behaviour during the pre‐discharge year and lack of behavioural improvement during treatment.ConclusionsOutcomes of mandatory treatment in this group of serious young offenders have not previously been studied in a rigorous pre–post intervention study design. We found evidence of an overall tendency to improvement over time in mental state and social skills, reflected by risk assessment scale scores. Continued substance use problems while incarcerated and continuing social skills deficits were most strongly associated with reincarceration suggests a possible need for review of these areas in the PIJ‐measure programme. Results contribute to knowledge about risk assessment, treatment and preventions of harms by serious young offenders and may inform evidence‐based policies and practices in the Netherlands and beyond.
Lumbar paraspinal atypical spindle cell/pleomorphic lipomatous tumor: A report of a rare case
Authors: Cheng Yu‐Wen , Chen Yang‐Yi , Kuo Chao‐Hung , Liao Wei‐Chuan , Kwan Aij‐Lie 
Published: January 2023

AbstractThe atypical spindle cell/pleomorphic lipomatous tumor (ASPLT) was classified as a new tumor by the World Health Organization (WHO) in 2020. The tumor is benign and commonly occurs in the limbs. Paraspinal presentations are rare. A 38‐year‐old man presented at our clinic complaining of sudden onset back pain. No neurological deficit was found. The magnetic resonance imaging (MRI) revealed a well‐defined heterogeneous mass in the left psoas muscle, from L1 to L3 extending over the L1 and L2 neuroforamen. The tumor was totally excised. Pathology led to an ASPLT diagnosis. Clinical symptoms improved and there was no postsurgical neurological deficit. This case of ASPLT, located in an uncommon location and present an unusual cluster of symptoms, could be treated by surgical excision, usually the first‐treatment strategy. Totally, removal was achieved because there was a clear morphological margin. The risk of metastatic dissemination was minimal, though there remains a nonnegligible risk of local recurrence.