bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of heparinized adult veno-arterial extracorporeal membrane oxygenation patients managed with low and high activated partial thromboplastin time targets: A systematic review and meta-analysis
Authors: Mazzeffi Michael , Lin Dora , Gonzalez-Almada Alberto , Stombaugh D Keegan , Curley Jonathan , Mangunta Venkat , Teman Nicholas , Yarboro Leora T , Thiele Robert 
Published: January 2023

Introduction There are no randomized controlled trials comparing low and high activated partial thromboplastin time (aPTT) targets in heparinized adult veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) patients. Our systematic review and meta-analysis summarized complication rates in adult VA ECMO patients treated with low and high aPTT targets. Methods Studies published from January 2000 to May 2022 were identified using Pubmed, Embase, Cochrane Library, and LILACS (Latin American and Caribbean Health Sciences Literature). Studies were included if aPTT was primarily used to guide heparin anticoagulation. For the low aPTT group, we included studies where aPTT goal was ≤60 seconds and for the high aPTT group, we included studies where aPTT goal was ≥60 seconds. Proportional meta-analysis with a random effects model was used to calculate pooled complication rates for patients in the two aPTT groups. Results Twelve studies met inclusion criteria (5 in the low aPTT group and 7 in the high aPTT group). The pooled bleeding complication incidence for low aPTT studies was 53.6% (95% CI = 37.4%–69.4%, I2 = 60.8%) and for high aPTT studies was 43.8% (95% CI = 21.7%–67.1%, I2 = 91.8%). No studies in the low aPTT group reported overall thrombosis incidence, while three studies in the high aPTT group reported overall thrombosis incidence. The pooled thrombosis incidence for high aPTT studies was 16.1% (95% CI = 9.0%–24.5%, I2 = 13.1%). Conclusions Adult ECMO patients managed with low and high aPTT goals appeared to have similar bleeding and other complication rates further highlighting the need for a randomized controlled trial.
Effectiveness of electrotherapy for the treatment of orofacial pain: A systematic review and meta-analysis
Authors: de Castro-Carletti Ester Moreira , Müggenborg Frauke , Dennett Liz , Sobral de Oliveira-Souza Ana Izabela , Mohamad Norazlin , Pertille Adriana , Rodrigues-Bigaton Delaine , Armijo-Olivo Susan 
Published: January 2023

Objective Summarize the evidence from randomized controlled trials and controlled trials that examined the effectiveness of electrotherapy in the treatment of patients with orofacial pain. Data Source Medline, Embase, CINAHL PLUS with Full text, Cochrane Library Trials, Web of Science, and Scopus. Review Methods A data search (last update, July 1, 2022) and a manual search were performed (October 5, 2022). Trials involving adults with orofacial pain receiving electrotherapy compared with any other type of treatment were included. The main outcome was pain intensity; secondary outcomes were mouth opening and tenderness. The reporting was based on the new PRISMA Guidelines. Results From the electronics databases and manual search 43 studies were included. Although this study was open to including any type of orofacial pain, only studies that investigated temporomandibular disorders were found. The overall quality of the evidence for pain intensity was very low. Although the results should be carefully used, transcutaneous electric nerve stimulation therapy showed to be clinically superior to placebo for reducing pain after treatment (2.63 [−0.48; 5.74]) and at follow-up (0.96 [−0.02; 1.95]) and reduce tenderness after treatment (1.99 [−0.33; 4.32]) and at follow-up (2.43 [−0.24; 5.10]) in subjects with mixed temporomandibular disorders. Conclusion The results of this systematic review support the use of transcutaneous electric nerve stimulation therapy for patients with mixed temporomandibular disorders to improve pain intensity, and tenderness demonstrating that transcutaneous electric nerve stimulation is superior to placebo. There is inconsistent evidence supporting the superiority of transcutaneous electric nerve stimulation against other therapies.
Impact of oral health management on mental health and psychological disease: a scoping review
Authors: Matsuda Shinpei , Yoshimura Hitoshi 
Published: January 2023

Objective The relationship between oral and mental health has been controversial. Few studies have assessed the direct effects of oral health management on mental health and psychological disease. Using evidence from the last 5 years, this scoping review aimed to map and discuss recent progress in understanding this relationship. Methods Electronic literature searches were performed using PubMed, Web of Science, the Cochrane Library, and the Cumulative Index to Nursing and Allied Health Literature databases. An additional manual search was performed using Google Scholar databases. Studies were selected using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 flow diagram. Results An eligibility review process identified three randomized controlled trials for inclusion in this review. The oral health interventions and participants’ target age, mental health status, and psychological diseases varied across these studies. The only study that reported an improvement included psychosocial support integrated with educational components of oral health as the intervention. The remaining two studies detected no significant impact of oral health interventions on mental health and psychological disease. Conclusions Evidence of the impact of oral health management on mental health and psychological disease is insufficient in studies published between 2017 and 2021.
Patients’ Experiences of Cancer Pain: A Descriptive Qualitative Study
Authors: Hassankhani Hadi , Hajaghazadeh Mohammad , Orujlu Samira 
Published: January 2023

Objective The aim of this study was to explore the cancer pain experiences of Iranian patients. Design A qualitative descriptive design was used. Methods This qualitative descriptive study was performed on 17 participants between December 2020 and September 2021. Data were collected using semistructured interviews and analyzed by Graneheim and Lundman's content analysis method. Results Three main categories emerged in relation to patients’ experiences of cancer pain. Categories included (1) characteristics of cancer pain, (2) pain self-management strategies, and (3) influence of pain on patient and her/his family. Conclusions Most patients believe that pain is God's will, and family members, doctors, and nurses can assist patients cope with pain by respecting this belief and supporting spiritual healing. Strengthening pain management strategies, expanding social networks, and convincing the patients that they are not an interruption to their families can all help patients maintain their fighting spirit and pain tolerance. To provide holistic care, healthcare providers, particularly nurses, should consider the physical, sociocultural, and spiritual aspects of cancer pain.
A novel Artificial Neural Network-based model for predicting dielectric properties of banana fiber filled with polypropylene composites
Authors: Doddashamachar Mahesh , Sen Snigdha , Nama Vasudeva Setty Raju 
Published: January 2023

The objective is focusing on the prediction of dielectric properties of the polypropylene composites reinforced with banana fiber using an Artificial Neural Network (ANN). To prepare the composites in accordance with ASTM requirements, randomly oriented banana fibers were combined with polypropylene at volume fractions of 20%, 30%, 40%, and 50%. For these composites, the impedance analyzer was used to determine dielectric characteristics such as the dielectric constant, tan δ, and ac conductivity. To estimate the dielectric properties, an artificial neural network is used with a supervised training strategy. The data set was assembled using ReLU, sigmoid, and tanh, three activation functions. Forecasting the outcome variables used temperature, frequency, filler content, and polymer content as input factors. Comparing the model utilizing ReLU to the other two activation functions, the MSE value was 0.32, and the R2 value was 0.98. Dielectric parameter values from both experiments and ANN modeling show a similar pattern. The dielectric properties of fiber-reinforced polyester matrix composites can be accurately predicted using ANN, reducing the need for manual intervention.
A mechanistic investigation about hepatoxic effects of borneol using zebrafish
Authors: Liu L , Yang Y , Yang F , Lin Y , Liu K , Wang X , Zhang Y 
Published: January 2023

Except for clinical value, borneol is routinely used in food and cosmetics with seldom safety evaluation. To investigate its hepatoxicity, we exposed 3 dpf (days post fertilization) larval zebrafish to borneol at a gradient of concentrations (200–500 μM) for 3 days. Herein, our results revealed that high doses of borneol (300–500 μM) caused liver size decrease or lateral lobe absence. Borneol also seriously disturbed the hepatic protein metabolism presented with the increased activity of alanine aminotransferase (ALT) and lipid metabolism shown with the increased level of triglycerides (TG) and total cholesterol (TC). The lipid accumulation (oil red staining) was detected as well. Additionally, significant upregulation of genes was detected that related to oxidative stress, lipid anabolism, endoplasmic reticulum stress (ERS), and autophagy. Conversely, the lipid metabolism-related genes were markedly downregulated. Moreover, the changes in the superoxide dismutase activity and the level of glutathione and malondialdehyde raised the likelihood of lipid peroxidation. The outcomes indicated the involvement of oxidative stress, ERS, lipid metabolism, and autophagy in borneol-induced lipid metabolic disorder and hepatic injury. This study will provide a more comprehensive understanding of borneol hepatoxicity and the theoretical basis for the safe use of this compound.
Comparison of tibial implant positioning between symmetrical and anatomical design implants in unicompartmental knee arthroplasty for Japanese patients
Authors: Miyake Yoshiaki , Namba Yoshifumi , Mitani Shigeru , Umehara Norifumi , Kawamoto Toyohiro , Furuichi Shuro 
Published: January 2023

Purpose In unicompartmental knee arthroplasty (UKA) procedures, maximizing the bone coverage of the tibial implant and eliminating the medial and posterior overhang would be optimal. We commonly used Physica ZUK® (ZUK), which is a symmetrical design. Alternatively, since Persona Partial Knee® (PPK) was developed in 2017 with an anatomical design to improve bone coverage, we started PPK. We hypothesized that the PPK facilitated better bone coverage than the ZUK without obvious overhangs. This study evaluated the bone coverage and the medial and posterior overhang of these differently designed tibial implants. Methods Seventy-nine knees from 68 patients who underwent UKA were evaluated. Cases were categorized into the ZUK (41 knees) and PPK (38 knees) groups. CT images were acquired before surgery and 1 week after surgery. We measured the tibial bone coverage, and the medial and posterior overhang by 3D software. Results The bone coverages were 103.8 ± 4.8% and 102.0 ± 3.0%, the medial overhangs were 2.2 ± 1.2 mm and 1.4 ± 1.1 mm, and the posterior overhangs were 0.6 ± 1.3 mm and 0.4 ± 1.2 mm for the ZUK and PPK groups, respectively. The bone coverage and medial overhang were significantly different between the groups, with ZUK being larger. Conclusion Patients who received PPK had significantly smaller medial overhangs and better bone coverage. PPK is more likely to give better results than ZUK.
Predictors of Adverse Outcomes Following Cleft Palate Repair: An Analysis of Over 2500 Patients Using International Smile Train Data
Authors: Chwa Emily S. , Stoehr Jenna R. , Gosain Arun K. 
Published: January 2023

ObjectiveThe objective of this study was to use data from Smile Train's global partner hospital network to identify patient characteristics that increase odds of fistula and postoperative speech outcomes.DesignMulti-institution, retrospective review of Smile Train Express database.Setting1110 Smile Train partner hospitals.Patients/Participants2560 patients.InterventionsN/A.Main Outcome Measure(s)Fistula occurrence, nasal emission, audible nasal emission with amplification (through a straw or tube) only, nasal rustle/turbulence, consistent nasal emission, consistent nasal emission due to velopharyngeal dysfunction, rating of resonance, rating of intelligibility, recommendation for further velopharyngeal dysfunction assessment, and follow-up velopharyngeal dysfunction surgeryResultsThe patients were 46.6% female and 27.5% underweight by WHO standards. Average age at palatoplasty was 24.7 ± 0.5 months and at speech assessment was 6.8 ± 0.1 years. Underweight patients had higher incidence of hypernasality and decreased speech intelligibility. Palatoplasty when under 6 months or over 18 months of age had higher rates of affected nasality, intelligibility, and fistula formation. The same findings were seen in Central/South American and African patients, in addition to increased velopharyngeal dysfunction and fistula surgery compared to Asian patients. Palatoplasty technique primarily involved one-stage midline repair.ConclusionsAge and nutrition status were significant predictors of speech outcomes and fistula occurrence following palatoplasty. Outcomes were also significantly impacted by location, demonstrating the need to cultivate longitudinal initiatives to reduce regional disparities. These results underscore the importance of Smile Train's continual expansion of accessible surgical intervention, nutritional support, and speech-language care.
Evaluation of Anxiety in Turkish Parents of Newborns with Cleft Palate with or Without Cleft Lip
Authors: Sunal Akturk Ezgi , Seker Elif Dilara , Capkın Duygu , Kutuk Mehmet Serdar 
Published: January 2023

Objective (1) To compare anxiety between parents of newborns with cleft lip and palate (CLP), isolated cleft palate (CP), and healthy newborns and (2) to evaluate anxiety between parental dyads within these groups. Design A cross-sectional study. Setting University Hospital. Participants Surveys were completed by 20 mothers and 20 fathers of newborns with CLP, 21 mothers and 21 fathers of newborns with CP, and 23 mothers and 23 fathers of healthy newborns (controls). Main Outcome Measure The State-Trait Anxiety Inventory (STAI) assessed parental anxiety. Mothers of newborns with a cleft reported on concerns regarding cleft-related issues and facial appearance. Results State and trait anxiety were generally in the moderate range for parents of newborns with a cleft, while control parents had low state anxiety and moderate trait anxiety. Mothers of newborns with CP and CLP had significantly higher state and trait anxiety levels than control mothers ( p < .05). Fathers of newborns with CLP had a higher state anxiety level than control fathers. When maternal and paternal anxiety was compared within the groups, only trait anxiety scores were significantly higher in mothers of newborns with CLP than that of fathers ( p < .05). More than half of mothers of newborns with a cleft were concerned about their newborn's feeding, speech, and palate. Conclusions Parents of children with a cleft may need psychological support in the early postnatal period. It is important for neonatal cleft team providers to help reduce parental anxiety and educate families about cleft care, with a focus on feeding.
Environmental Management and Sanitation as a Malaria Vector Control Strategy: A Qualitative Cross-Sectional Study Among Stakeholders, Sunyani Municipality, Ghana
Authors: Agyemang-Badu Samuel Yaw , Awuah Esi , Oduro-Kwarteng Sampson , Dzamesi Justice Yao Woelinam , Dom Nazri Che , Kanno Girum Gebremeskel 
Published: January 2023

Background: For centuries malaria infection remains a public health burden globally as well as in the Sunyani Municipality. This exploratory qualitative study aimed to assess the prospects of environmental management and sanitation (EMS) as a malaria vector control strategy among key stakeholders involved in the prevention and control of malaria in Sunyani Municipality, Ghana. Method: We used an exploratory qualitative study and a designed focus group discussion (FGD) guide (with specific research questions) to solicit opinions and/or views among Malaria Control Focal Persons, Environmental Health Officers (Health Inspectors), and Honourable Assembly Members. Data were collected between December 2019 and February 2020. The responses were analyzed according to the specific research questions. Result: Findings from this study shows that high government support and/or political will by investing in environmental sanitation infrastructure, creating the enabling environment for strict enforcement of environmental sanitation bye-laws by Environmental Health Officers/Health Inspectors, effective and efficient collaboration among key stakeholders and organization of communal labor activities is likely to help reduce the majority of the mosquito breeding sites. Conclusion: The prospects of environmental management and sanitation (EMS) as a vector control strategy, look promisingly very high, pertinent, and workable and a likelihood game changer of winning the fight against malaria due to the residual transmission that is happening outdoors. However, EMS can be employed as a supplementary method to the current core vector control methods if the following conditions and bottlenecks are addressed and in place: (a) Effective collaboration among key stakeholders at all levels; (b) Adequate allocation of funds to the Environmental Health and Sanitation Department; (c) Enactment of robust educational campaigns across all educational levels and via different media; (d) Recognition, empowerment, and adequate resourcing of Environmental Health Officers; (e) Adherence to the building regulations to prevent encroachment of natural wetlands; (f) Revision of fees/fines and prosecution of sanitary offenders; (g) Enactment of an Environmental Sanitation Day (ESD), and establishment of the Environmental Health and Sanitation Fund (EHSF).
Driving factors and models of window opening behaviour in Xi’an residential buildings
Authors: Liu Jiali , Wei Ying’an , Meng Qinglong , Lei Yu 
Published: January 2023

Window opening behaviour is an important factor which affects the consumption of building energy. Finding out the driving factors and establishing an accurate model for window opening behaviour can improve the accuracy of the simulation of building energy consumption. However, the window opening behaviour is affected by various driving factors and has strong uncertainty, which brings difficulties for the dynamic simulation of building energy consumption. Residential buildings that were chosen had a similar number of residents, and indoor and outdoor environmental parameters and states of the windows were monitored for one year in Xi’an. The multi-factor variance method was used to analyse the influence of environmental factors, and logistic regression and back propagation neural network models were established for different seasons. The study found that the window opening frequency in the bedroom is higher than in the living room. The driving factors which affect window opening behaviour vary with seasons, and indoor and outdoor temperatures and humidity are the dominant factors. The accuracy of the proposed BP neural network models is above 70%, and the area under curve value is all above 0.7. These models can provide theoretical support for the modelling of the residential building in Xi’an.
Towards a theory of reparative multiculturalism
Authors: Lambrecht Felix 
Published: January 2023

Contemporary liberal states must provide an answer to the “question of cultural diversity”, requiring a principled way to determine which minority cultural practices a state must accommodate and support. (Liberal egalitarian) multiculturalism answers this question neatly by creating a dichotomy between national minorities and ethnic minorities (the national/ethnic “dichotomy” ). Where national minorities are entitled to extensive and far-reaching cultural rights, ethnic minorities are entitled to significantly fewer cultural rights and accommodations. This dichotomy is enacted through a distributive logic that allocates cultural rights to achieve equal individual autonomy. But the dichotomy is also influenced by the ways these groups were incorporated into the state. Their modes of incorporation are different and, thus, they have different requirements to achieve equally autonomous lives. Critics have challenged multiculturalism by questioning this dichotomy . They have suggested that the dichotomy does not adequately capture differences in kinds of minority groups and their entitlements. This paper defends the dichotomy by offering a supplementary principle to liberal egalitarian multiculturalism: the reparative multicultural principle. This principle allocates cultural rights as part of reparative entitlements for historical and ongoing injustices committed against minority groups. Supplementing multiculturalism in this way more accurately captures the idea of the historical mode of incorporation that inspires the dichotomy and can help resolve some the objections to multiculturalism.
Couples living with Alzheimer’s disease talk about sex and intimacy: A phenomenological qualitative study
Authors: Albert Susan Carol , Eduardo Martinelli José , Costa Pessoa Maria Silvia 
Published: January 2023

Objectives To obtain a deeper understanding of the phenomenon of sexuality within the couple relationship when one of the partners has received a diagnosis of Alzheimer’s Disease. This study aimed to listen to the voices of both partners, and to investigate how their intimate relationship has been impacted by an Alzheimer’s diagnosis. Methods This study adopted a qualitative phenomenological approach, and the method used was Interpretative Phenomenological Analysis. The data was collected based on interviews with six couples, where one of the spouses had a mild to moderate Alzheimer’s diagnosis. The interviews were recorded and transcribed, and a detailed analysis of each interview was performed. Findings From the detailed analysis of the transcribed interviews, six main themes emerged: Sexual expression today; Alzheimer’s and sexuality; desire to be a sexual being; different sexualities; sense of couplehood; and uncertain future. Conclusions The findings of this study provide a deeper insight into experiences of sexuality for couples living with Alzheimer’s. Sexuality and intimacy of couples living with Alzheimer’s continues to be an important aspect of the relationship, and in general, the partners wish to have the opportunity to express their sexuality. The construction of a sense of couplehood during the marriage tends to be a significant factor to sustain the changes that arise in the intimate relationship because of the diagnosis. However, despite the growing recognition of the existence and importance of sexuality in later life, persons with Alzheimer’s have only recently starting to be recognized as sexual beings who wish to be heard.