bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 3D-printed pedal fixator for connecting different pedal-operated tools reduces the number of mistakes during endoscopic submucosal dissection
Authors: Yzet Clara , Rivory Jérôme , Wallenhorst Thimothee , Grainville Thomas , Legros Romain , Lepilliez V. , Leblanc Sarah , Figueiredo Ferreira Mariana , Perron Léa , Lafeuille Pierre , Mochet Mikael , Virely Mélia , Leplat-Bonnevialle Peggy , Jacques Jeremie , Pioche Mathieu 
Published: May 2023

Abstract
Background and study aims What distinguishes endoscopic submucosal dissection (ESD) from endoscopic mucosal resection is the need for three foot pedals to activate the electrosurgical unit, flushing and knife injection. The lack of connection between the various pedals of different shapes and brands leads to numerous pedals displacements and potential mistakes. The aim of this study was to evaluate an Innovative PEdal FIXator (IPEFIX) to reduce pedal mistakes during ESD.
Methods This was a prospective, multicenter, randomized study. Consecutive ESD procedures were randomly assigned to two groups: a control group with the three pedals free and the IPEFIX group in which the three pedals were linked by IPEFIX. The main outcome evaluated was the number of foot mistakes (wrong pedal, foot push beside the pedal).
Results A total of 107 ESDs were performed by eight experts in five centers. The median number of mistakes per hour of ESD procedure was 0/h in the IPEFIX group and 1.9/h in the control group (P <0.001). The mean number of times to look down to control the position of the pedals was 2.2/h the IPEFIX group and 7.7/h in the control group (P <0.001). Mean replacements of the pedals were 0./h in the IPEFIX group and 1.7/h in the control group (P <0.001). Similar results were obtained in trainees in simulated ESD on animal models.
Conclusions IPEFIX is a simple device to connect different pedals during endoscopic procedures. It helps to reduce the numbers of foot mistakes during ESD and improves operator comfort.
EUS-guided transcolonic drainage and necrosectomy in walled-off necrosis: a retrospective, single-center case series
Authors: Ebrahim Mohamed , Novovic Srdan , Schmidt Palle Nordblad , Feldager Hansen Erik , Karstensen John Gásdal 
Published: May 2023

Abstract
Background and study aims Transgastric endoscopic ultrasound (EUS)-guided drainage and, if needed, necrosectomy is the preferred treatment in patients with pancreatic walled-off necrosis. EUS-guided transcolonic or transrectal drainage and necrosectomy may serve as a minimally invasive alternative in cases in which transgastric or percutaneous drainage is either impossible or fails to secure sufficient drainage. In this paper, we retrospectively evaluated the feasibility, safety, and efficacy of the treatment. We included nine patients and found a technical success rate of 100%, clinical success in 89%, and one adverse event (11%). Transrectal/transcolonic endoscopic necrosectomy was needed in seven patients (78%).
From Sweet Molecular Giants to Square Sugars and Vice Versa
Authors: Compain Philippe 
Published: May 2023

AbstractThis account describes our recent studies in the field of glycomimetics. Our efforts in understanding the structural basis of multivalent effects in glycosidase inhibition have led to decisive mechanistic insights supported by X-ray diffraction analyses and to the discovery of multimeric iminosugars displaying one of the largest binding enhancements reported so far for a non-polymeric enzyme inhibitor. Pushing the limits of the inhibitory multivalent effect has also driven progress in synthetic methodology. The unexpected observation of side products en route to the synthesis of our targets has been the starting point of several new synthetic methodologies, including metal-free deoxygenation of alcohols and one-pot double thioglycosylation. In parallel to our work on ‘giant’ neoglycoclusters, we have developed access to original constrained glycomimetics based on a 4-membered ring (‘square sugars’). Carbohydrates with a quaternary (pseudo)anomeric position were also synthesized from exo-glycals through catalytic hydrogen atom transfer and a novel oxidative radical-polar crossover process.1	Introduction2	Sweet Giants3	Multivalency Spin-Offs4	Sweet Curiosities4.1	Square Sugars4.2	From C,C-Glycosides to Formal Glycosylation of Quinones5	Conclusion
Rare Isolated Cerebellar Metastases in Prostate Cancer: A Case Report with Review of Literature
Authors: Ajit Nimmagadda , Tejonath Gadepalli , Pratyusha Bikkina , Zakir Abubacker Ali 
Published: May 2023

AbstractProstate cancer is a common malignancy affecting elderly males. Generally, prostate cancer metastases to lymph nodes and skeletal lesions. Brain metastasis from prostate cancer is an uncommon phenomenon. When occurs, it affects the liver and lungs. Less than 1% of the cases show brain metastases, with isolated brain metastases being even more rare. We present the case of a 67-year-old male patient who was diagnosed to have prostate carcinoma and maintained on hormonal therapy. Later, the patient presented with raising serum-68 prostate-specific antigen (PSA) levels. Gallium-68 prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) scan revealed isolated cerebellar metastasis. He was later treated with whole brain radiotherapy.
The Role of CD36/GPIV in Platelet Biology
Authors: Bendas Gerd , Schlesinger Martin 
Published: May 2023

AbstractCD36 (also known as platelet glycoprotein IV) is expressed by a variety of different cell entities, where it possesses functions as a signaling receptor, but additionally acts as a transporter for long-chain fatty acids. This dual function of CD36 has been investigated for its relevance in immune and nonimmune cells. Although CD36 was first identified on platelets, the understanding of the role of CD36 in platelet biology remained scarce for decades. In the past few years, several discoveries have shed a new light on the CD36 signaling activity in platelets. Notably, CD36 has been recognized as a sensor for oxidized low-density lipoproteins in the circulation that mitigates the threshold for platelet activation under conditions of dyslipidemia. Thus, platelet CD36 transduces atherogenic lipid stress into an increased risk for thrombosis, myocardial infarction, and stroke. The underlying pathways that are affected by CD36 are the inhibition of cyclic nucleotide signaling pathways and simultaneously the induction of activatory signaling events. Furthermore, thrombospondin-1 secreted by activated platelets binds to CD36 and furthers paracrine platelet activation. CD36 also serves as a binding hub for different coagulation factors and, thus, contributes to the plasmatic coagulation cascade. This review provides a comprehensive overview of the recent findings on platelet CD36 and presents CD36 as a relevant target for the prevention of thrombotic events for dyslipidemic individuals with an elevated risk for thrombosis.
Inhibitors of Polyphosphate and Neutrophil Extracellular Traps
Authors: Vappala Sreeparna , Smith Stephanie A. , Kizhakkedathu Jayachandran N. , Morrissey James H. 
Published: May 2023

AbstractThe contact pathway of blood clotting has received intense interest in recent years as studies have linked it to thrombosis, inflammation, and innate immunity. Because the contact pathway plays little to no role in normal hemostasis, it has emerged as a potential target for safer thromboprotection, relative to currently approved antithrombotic drugs which all target the final common pathway of blood clotting. Research since the mid-2000s has identified polyphosphate, DNA, and RNA as important triggers of the contact pathway with roles in thrombosis, although these molecules also modulate blood clotting and inflammation via mechanisms other than the contact pathway of the clotting cascade. The most significant source of extracellular DNA in many disease settings is in the form of neutrophil extracellular traps (NETs), which have been shown to contribute to incidence and severity of thrombosis. This review summarizes known roles of extracellular polyphosphate and nucleic acids in thrombosis, with an emphasis on novel agents under current development that target the prothrombotic activities of polyphosphate and NETs.
Comparative Study of Perinatal Outcome in Uncomplicated Monochorionic Diamniotic versus Dichorionic Diamniotic Twins at a Specialized Twin Clinic—A Prospective Study
Authors: Jakkidi Anusha , Singh Arati , Redishetty Saritha , Kavuri Kamala , Reddy Prathibha , Shah Aditi , Kachakayala Mounika , Kolar Geeta , Vavilala Suseela 
Published: May 2023

Abstract
Background Monochorionic twins have higher perinatal morbidity and mortality than dichorionic twins. However, there is conflicting data on outcomes of uncomplicated monochorionic twins.
Purpose of the Study The aim of this study is to compare the outcomes of apparently uncomplicated monochorionic twins to dichorionic twins.
Methods This is a prospective study conducted from August 2019 to December 2020 at a specialized twin clinic. All twins, whose chorionicity was determined before 14 weeks with two live fetuses at 24 weeks, were recruited. Complicated monochorionic diamniotic (MCDA) twins with twin-to-twin transfusion syndrome, twin anemia polycythemia syndrome, selective fetal growth restriction before 24 weeks and single or double fetal demise before 24 weeks were excluded. Other exclusion criteria were major congenital and chromosomal abnormalities, higher order multiples, monoamniotic twins, and twins with undetermined chorionicity antenatally. Both the groups were followed till delivery and neonates followed till 28 days. Maternal and neonatal outcomes were studied and compared.
Results One-hundred forty-eight mothers with dichorionic diamniotic (DCDA) and 74 with uncomplicated MCDA were studied. Mean gestational age at delivery was 35 weeks in both the groups. Maternal, fetal, and neonatal morbidities were similar in both, except early onset preeclampsia that was higher in the DCDA group. Prospective risk of stillbirth for DCDA and MCDA after 24 weeks was 1.35 and 4.05%, respectively. Prospective risk of stillbirth for DCDA and MCDA after 30 weeks was 1.49 and 0%, respectively.
Conclusion The maternal and perinatal outcomes in uncomplicated MCDA twins are similar to DCDA twins. Prospective risk of stillbirth after 30 weeks is extremely low. Hence, uncomplicated MCDA twins should not be delivered electively before 36 weeks.
A Case Report on Prenatal Diagnosis of Evolving Cortical Malformations: A Rare Ultrasound Marker
Authors: Shah Aditi , Bharathi Navya , Reddy Tejaswi 
Published: May 2023

AbstractMalformations of cortical development are rarely diagnosed in utero. Cortical malformations are aberrations in the process of corticogenesis. We report two rare and unique cases of evolving cortical malformation with unusual ultrasonogram markers: (1) narrow cavum septum pellucidum and (2) ill-defined and irregular lateral ventricular borders on the midtrimester anomaly scan. This was further confirmed by fetal brain evaluation on magnetic resonance imaging with additional information on irregular ventricular borders, scattered hyperintensities in the cerebral parenchyma and periventricular area, loss of cerebral layering pattern at 24 weeks gestation in one case, and hemimegalencephaly in another case with a probable diagnosis of evolving cortical malformation. Literature review reveals the above as an unusual presentation on the anomaly scan.
Luminescence properties related anti-phase domain of alpha-Ga2O3
Authors: Lee Yong-Hee , Gil Byeongjun , Yang Duyoung , Sheen Mi-Hyang , Yoon Euijoon , Park Yongjo , Jang Ho-Won , Yoon Sangmoon , Kim Miyoung , Kim Young-Woon 
Published: May 2023

This work investigates the relationship between atomic arrangement and luminescence properties in a high-quality alpha-Ga2O3 thin film grown on an Al2O3 single-crystal membrane. The strain induced by merging domain boundaries shows more significant variability in annular darkfield images even though there is no additional gallium concentration confirmed. The bandgap energy of alpha-Ga2O3 is estimated to be 5.56 eV from the CL measurement in a transmission electron microscope. A peak at 320 nm was observed within the domain, while the domain boundary showed spectrum peaks with 380–480 nm. The anti-phase domain (APD) is formed by the instabilities of Al–O bonding templates provided by the Al2O3 substrate. The APD boundary gives a characteristic wavelength of 350 nm, which is the result of the merging boundary of in-phase and anti-phase domains.
Investigation of orthogonal spin–orbit fields in crystalline ferromagnetic films with four-fold in-plane magnetic anisotropy
Authors: Han Kyoul , Lee Kyung Jae , Lee Sanghoon , Liu Xinyu , Dobrowolska Margaret , Furdyna Jacek K. 
Published: May 2023

We report an investigation of current-induced spin–orbit fields (SOFs) in a crystalline (Ga,Mn)As ferromagnetic film with four-fold in-plane anisotropy. By designing a Hall device with current channels along crystallographic 〈100〉 directions, we observe the effects of SOFs in all four magnetization transitions over the four 〈110〉 hard axes of the film. The SOF effects are observed in the form of opposite shifts of angles at which the magnetization of the film switches sign for opposite current polarities in anisotropic magnetoresistance (AMR) measurements carried out as the applied magnetic field was rotated. Note that the Dresselhaus- and Rashba-type SOFs generated by currents flowing along the 〈100〉 directions—as in the device designed for the present experiments—are orthogonal to one another and can thus be separated by appropriate analysis of AMR. The analysis of experimental results based on magnetic free energy, in which the effects of SOFs are included, reveals that the Dresselhaus-type SOF is much stronger than the Rashba-type SOF. The values of the two SOFs obtained independently with currents flowing either along the [100] or [010] channels are consistent with each other, showing the reliability of the above-mentioned approach for investigating SOFs in ferromagnetic films.
Ab initio simulation of peak evolutions and beating maps for electronic two-dimensional signals of a polyatomic chromophore
Authors: Zhan Siying , Gelin Maxim F. , Huang Xiang , Sun Kewei 
Published: May 2023

By employing the doorway-window (DW) on-the-fly simulation protocol, we performed ab initio simulations of peak evolutions and beating maps of electronic two-dimensional (2D) spectra of a polyatomic molecule in the gas phase. As the system under study, we chose pyrazine, which is a paradigmatic example of photodynamics dominated by conical intersections (CIs). From the technical perspective, we demonstrate that the DW protocol is a numerically efficient methodology suitable for simulations of 2D spectra for a wide range of excitation/detection frequencies and population times. From the information content perspective, we show that peak evolutions and beating maps not only reveal timescales of transitions through CIs but also pinpoint the most relevant coupling and tuning modes active at these CIs.
Female mate choice in the fat-tailed dunnart (Sminthopsis crassicaudata) influences offspring sex ratio, but not fecundity
Authors: Gill Brittney P. , Edwards Amy M. , Parrott Marissa L. , Scicluna Emily L. , Robert Kylie A. 
Published: May 2023

Obtaining a suitable mate is an integral part of reproduction, with sexual selection processes such as female mate choice resulting in both direct and/or indirect benefits. Here, we investigated whether olfactory driven female mate choice influenced reproductive success in captive fat-tailed dunnarts (Sminthopsis crassicaudata). Although females spent 67% more time with a preferred male’s scent, reproductive success was not influenced by assigned mate choice. Of the 10 (of 12) litters that survived to weaning, average litter size was higher for non-preferred pairings (3 ± 0.83) compared with preferred pairings (1.6 ± 0.60), with weaning success equal for both pairings. Analyses suggested that offspring sex ratios were influenced by mate choice, with females paired with their preferred mate having more daughters (81%) in comparison to non-preferred pairings (44%) and by paternal body condition, whereby females paired with males in better body condition produced more sons. In this species, altering offspring sex ratios in favour of daughters may be achieved by pairing with preferred males, and towards sons by pairing with males in better body condition. With the increasing need for captive breeding programs, these techniques may provide opportunities to correct sex ratio biases and incorporate natural mating systems into conservation programs.
Characterization of the thermal conductivity and diffusivity of graphene nanoplatelets strips: a low-cost technique
Authors: Giovinco G , Sibilia S , Maffucci A 
Published: May 2023

Abstract
This paper proposes a new technique to characterize the thermal conductivity and diffusivity of thin strips made by graphene nanoplatelets (GNP). The evaluation of these parameters is essential for a reliable design of thermal and electrothermal applications of graphene and is usually performed by means of assessed but expensive techniques such as those based on Raman effects and laser flash. The technique proposed here is simpler and less demanding in terms of equipment, and combines the results of an experimental characterization of the strip heated by the Joule effect obtained with infrared camera, with those provided by an electro-thermal model. Specifically, the evaluation of the thermal conductivity and diffusivity is the result of the analysis of the transient behavior of the measured and simulated solutions. The methodology is here successfully validated by applying it to commercial graphene strips and benchmarking against the thermal parameters provided by the manufacturers. Then, a complete characterization is provided for commercial strips based on different formulations of GNP and binders such as polyurethane, epoxy resin, and boron nitride. For these materials, the values of thermal conductivity and diffusivity are found in the ranges (50–450) W m−1 K−1 and (0.5–3.5) × 10−4 m2 s−1, respectively.
A denoising model based on multi-agent reinforcement learning with data transformation for digital tomosynthesis
Authors: Nam Kibok , Lee Dahye , Lee Seungwan 
Published: May 2023

Abstract

Objective. Denoising models based on the supervised learning have been proposed for medical imaging. However, its clinical availability in digital tomosynthesis (DT) imaging is limited due to the necessity of a large amount of training data for providing acceptable image quality and the difficulty in minimizing a loss. Reinforcement learning (RL) can provide the optimal pollicy, which maximizes a reward, with a small amount of training data for implementing a task. In this study, we presented a denoising model based on the multi-agent RL for DT imaging in order to improve the performance of the machine learning-based denoising model. Approach. The proposed multi-agent RL network consisted of shared sub-network, value sub-network with a reward map convolution (RMC) technique and policy sub-network with a convolutional gated recurrent unit (convGRU). Each sub-network was designed for implementing feature extraction, reward calculation and action execution, respectively. The agents of the proposed network were assigned to each image pixel. The wavelet and Anscombe transformations were applied to DT images for delivering precise noise features during network training. The network training was implemented with the DT images obtained from the three-dimensional digital chest phantoms, which were constructed by using clinical CT images. The performance of the proposed denoising model was evaluated in terms of signal-to-noise ratio (SNR), structural similarity (SSIM) and peak signal-to-noise ratio (PSNR). Main results. Comparing the supervised learning, the proposed denoising model improved the SNRs of the output DT images by 20.64% while maintaining the similar SSIMs and PSNRs. In addition, the SNRs of the output DT images with the wavelet and Anscombe transformations were 25.88 and 42.95% higher than that for the supervised learning, respectively. Significance. The denoising model based on the multi-agent RL can provide high-quality DT images, and the proposed method enables the performance improvement of machine learning-based denoising models.
SQUID current sensors with an integrated thermally actuated input current limiter
Authors: Körber R , Krzysteczko P , Klemm M , Liu T , Storm J-H , Beyer J 
Published: May 2023

Abstract
The development of superconducting quantum interference device (SQUID) current sensors with a thermally actuated input current limiter (TCL) integrated into the input circuit of the sensor is presented. The TCL is based on an unshunted Josephson Junction (JJ) series array, around which meanders a galvanically isolated, but tightly, thermally coupled, resistive heater element. By applying a current to the heater, the JJ critical currents can be reduced or completely suppressed, while the other on-chip SQUID circuit elements remain unaffected. The functional parameters of the TCL are determined by direct transport measurements and by static and dynamic flux coupling tests via the input circuit. In liquid helium, a heater power, which reliably suppresses the critical current of the JJ array to zero, of ∼1.5 mW was needed, with the TCL normal state resistance being at 500 Ω. In this configuration, typical TCL switching times of approximately 20 µs were observed in the direct transport measurements. The TCL can be used to temporarily or even permanently disable malfunctioning channels in multichannel SQUID magnetometer systems, when feedback into their otherwise superconducting input circuits is not possible. In doing so, significant signal distortions in neighbouring channels from screening currents in these input circuits are avoided. Furthermore, by completely suppressing and restoring the TCL critical current, dc offset currents in the superconducting input circuits can be prevented. This is relevant, for instance, in SQUID-based spin precession experiments on hyperpolarized noble gases, in which even dc currents of a few µA in the input circuit can lead to significant magnetic field distortions in the adjacent sample region contributing to the transverse spin-spin relaxation rate

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Study of surface morphology in GaAs by hydrogen and helium implantation at elevated temperature
Authors: Huang Rui , Wang Zhiyong , Li Hui , Wang Qing , Guo Yecai 
Published: May 2023

Abstract
In this work, the surface morphology and internal defect evolution process of GaAs substrates implanted with light ions of different fluence combinations are studied. The influence of H and He ions implantation on the atomic mechanism of the blister phenomenon observed after annealing is investigated. Raman spectroscopy is used to measure the surface stress change of different samples before and after implantation and annealing. Optical microscopy and atomic force microscopy are used to characterize the morphology changes of the GaAs surface under different annealing conditions. The evolution of bubbles and defects in GaAs crystals is revealed by transmission electron microscopy. Through this study, it is hoped that ion implantation fluence, surface exfoliation efficiency and exfoliation cost can be optimized. At the same time, it also lays a foundation for the heterointegration of GaAs film on Si.