bluuebunny/crossref_metadata_2025_split huggingface dataset:
Encryption‐Decryption Strategy of High Security Constructed via Encoded Fluorescence Sensing and Linear Discriminant Analysis Technique
Authors: Ji Haiwei , Chen Huanhuan , Mao Tianzhi , Zhao Lingfeng , Zhang Ke , Yang Majun , Zhou Xiaobo , Wang Qi , Wu Li , Qin Yuling 
Published: June 2023

AbstractInnovative fluorescence materials combining the special reagent stimuli response have considerable potential to provide a convenient and highly secure communication strategy for encoding messages. With the unique decryption method, encrypted information that is previously unidentifiable can now be accurately parsed without the risk of interception or decipherment. Herein, white‐emitting light semiconducting polymer dots for advanced secret communication are developed, along with a machine learning‐based encryption‐decryption strategy. The encrypted data are readily hidden by the fluorescent polymer‐stimulus system, which can be identified by fluorescence imaging equipment and only be decrypted via the special linear discriminant analysis route pre‐transferred to the recipient. The results presented here suggest that chemical‐stimulated fluorescence information storage and the unique decoding strategy can be developed as prospective methods for advanced data communication and security protection.
Pathways to Next‐Generation Fire‐Safe Alkali‐Ion Batteries
Authors: Zhang Yubai , Feng Jiabing , Qin Jiadong , Zhong Yu Lin , Zhang Shanqing , Wang Hao , Bell John , Guo Zaiping , Song Pingan 
Published: June 2023

AbstractHigh energy and power density alkali‐ion (i.e., Li+, Na+, and K+) batteries (AIBs), especially lithium‐ion batteries (LIBs), are being ubiquitously used for both large‐ and small‐scale energy storage, and powering electric vehicles and electronics. However, the increasing LIB‐triggered fires due to thermal runaways have continued to cause significant injuries and casualties as well as enormous economic losses. For this reason, to date, great efforts have been made to create reliable fire‐safe AIBs through advanced materials design, thermal management, and fire safety characterization. In this review, the recent progress is highlighted in the battery design for better thermal stability and electrochemical performance, and state‐of‐the‐art fire safety evaluation methods. The key challenges are also presented associated with the existing materials design, thermal management, and fire safety evaluation of AIBs. Future research opportunities are also proposed for the creation of next‐generation fire‐safe batteries to ensure their reliability in practical applications.
Total Synthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites**
Authors: Angyal Péter , Hegedüs Kristóf , Mészáros Bence Balázs , Daru János , Dudás Ádám , Galambos Anna Rita , Essmat Nariman , Al‐Khrasani Mahmoud , Varga Szilárd , Soós Tibor 
Published: June 2023

AbstractMitragynine pseudoindoxyl, a kratom metabolite, has attracted increasing attention due to its favorable side effect profile as compared to conventional opioids. Herein, we describe the first enantioselective and scalable total synthesis of this natural product and its epimeric congener, speciogynine pseudoindoxyl. The characteristic spiro‐5‐5‐6‐tricyclic system of these alkaloids was formed through a protecting‐group‐free cascade relay process in which oxidized tryptamine and secologanin analogues were used. Furthermore, we discovered that mitragynine pseudoindoxyl acts not as a single molecular entity but as a dynamic ensemble of stereoisomers in protic environments; thus, it exhibits structural plasticity in biological systems. Accordingly, these synthetic, structural, and biological studies provide a basis for the planned design of mitragynine pseudoindoxyl analogues, which can guide the development of next‐generation analgesics.
Non‐activated Esters as Reactive Handles in Direct Post‐Polymerization Modification
Authors: Van Guyse Joachim F. R. , Bernhard Yann , Podevyn Annelore , Hoogenboom Richard 
Published: June 2023

AbstractNon‐activated esters are prominently featured functional groups in polymer science, as ester functional monomers display great structural diversity and excellent compatibility with a wide range of polymerization mechanisms. Yet, their direct use as a reactive handle in post‐polymerization modification has been typically avoided due to their low reactivity, which impairs the quantitative conversion typically desired in post‐polymerization modification reactions. While activated ester approaches are a well‐established alternative, the modification of non‐activated esters remains a synthetic and economically valuable opportunity. In this review, we discuss past and recent efforts in the utilization of non‐activated ester groups as a reactive handle to facilitate transesterification and aminolysis/amidation reactions, and the potential of the developed methodologies in the context of macromolecular engineering.
New Anderson‐Based Polyoxometalate Covalent Organic Frameworks as Electrodes for Energy Storage Boosted Through Keto‐Enol Tautomerization
Authors: Pakulski Dawid , Gorczyński Adam , Brykczyńska Daria , Montes‐García Verónica , Czepa Włodzimierz , Janica Iwona , Bielejewski Michał , Kubicki Maciej , Patroniak Violetta , Samorì Paolo , Ciesielski Artur 
Published: June 2023

AbstractThe unique electrochemical properties of polyoxometalates (POMs) render them ideal components for the fabrication of next‐generation high‐performance energy storage systems. However, their practical applications have been hindered by their high solubility in common electrolytes. This problem can be overcome by the effective hybridization of POMs with other materials. Here we present the design and synthesis of two novel polyoxometalate‐covalent organic frameworks (POCOF) via one‐pot solvothermal strategy between an amino‐functionalized Anderson‐type POM and a trialdehyde‐based building unit. We show that structural and functional complexity can be enriched by adding hydroxyl groups in the 2,4,6 position to the benzene‐1,3,5‐tricarbaldehyde allowing to exploit for the first time in POCOFs the keto‐enol tautomerization as additional feature to impart greater chemical stability to the COFs and enhanced properties leading to large specific surface area (347 m2/g) and superior electrochemical performance of the POCOF‐1 electrodes, when compared with POCOF‐2 electrodes that possess only imine‐type linkage and with pristine POM electrodes. Specifically, POCOF‐1 electrodes display remarkable specific, areal, and volumetric capacitance (125 F/g, 248 mF/cm2 and 41.9 mF/cm3, respectively) at a current density of 0.5 A/g, a maximum energy density (56.2 Wh/kg), a maximum power density (3.7 kW/kg) and an outstanding cyclability (90 % capacitance retention after 5000 cycles).
Desolvation‐Induced Highly Symmetrical Terbium(III) Single‐Molecule Magnet Exhibiting Luminescent Self‐Monitoring of Temperature
Authors: Wang Junhao , Zakrzewski Jakub J. , Zychowicz Mikolaj , Xin Yue , Tokoro Hiroko , Chorazy Szymon , Ohkoshi Shin‐ichi 
Published: June 2023

AbstractA conjunction of Single‐Molecule Magnet (SMM) behavior and luminescence thermometry is an emerging research line aiming at contactless read‐out of temperature in future SMM‐based devices. The shared working range between slow magnetic relaxation and the thermometric response is typically narrow or absent. We report TbIII‐based emissive SMMs formed in a cyanido‐bridged framework whose properties are governed by the reversible structural transformation from [TbIII(H2O)2][CoIII(CN)6] ⋅ 2.7H2O (1) to its dehydrated phase, TbIII[CoIII(CN)6] (2). The 8‐coordinated complexes in 1 show the moderate SMM effect but it is enhanced for trigonal‐prismatic TbIII complexes in 2, showing the SMM features up to 42 K. They are governed by the combination of QTM, Raman, and Orbach relaxation with the energy barrier of 594(18) cm−1 (854(26) K), one of the highest among the TbIII‐based molecular nanomagnets. Both systems exhibit emission related to the f–f electronic transitions, with the temperature variations resulting in the optical thermometry below 100 K. The dehydration leads to a wide temperature overlap between the SMM behavior and thermometry, from 6 K to 42 K. These functionalities are further enriched after the magnetic dilution. The role of post‐synthetic formation of high‐symmetry TbIII complexes in achieving the SMM effect and hot‐bands‐based optical thermometry is discussed.
Biomimetic Design of a Robustly Stabilized Folded State Enabling Seed‐Initiated Supramolecular Polymerization under Microfluidic Mixing**
Authors: Ogi Soichiro , Takamatsu Aiko , Matsumoto Kentaro , Hasegawa Shintaro , Yamaguchi Shigehiro 
Published: June 2023

AbstractWe have investigated the folding and assembly behavior of a cystine‐based dimeric diamide bearing pyrene units and solubilizing alkyl chains. In low‐polarity solvents, it forms a 14‐membered ring through double intramolecular hydrogen bonds between two diamide units. The spectroscopic studies revealed that the folded state is thermodynamically unstable and eventually transforms into more energetically stable helical supramolecular polymers that show an enhanced chiral excitonic coupling between the transition dipoles of the pyrene units. Importantly, compared to an alanine‐based monomeric diamide, the dimeric diamide exhibits a superior kinetic stability in the metastable folded state, as well as an increased thermodynamic stability in the aggregated state. Accordingly, the initiation of supramolecular polymerization can be regulated using a seeding method even under microfluidic mixing conditions. Furthermore, taking advantage of a self‐sorting behavior observed in a mixture of l‐cysteine‐ and d‐cysteine‐based dimeric diamides, a two‐step supramolecular polymerization was achieved by stepwise addition of the corresponding seeds.
Crystalline Nanoparticles of Water‐Soluble Covalent Basket Cages (CBCs) for Encapsulation of Anticancer Drugs
Authors: Liyana Gunawardana Vageesha W. , Ward Carson , Wang Han , Holbrook Joseph H. , Sekera Emily R. , Cui Honggang , Hummon Amanda B. , Badjić Jovica D. 
Published: June 2023

AbstractWe herein describe the preparation, assembly, recognition characteristics, and biocompatibility of novel covalent basket cage CBC‐11, composed of four molecular baskets linked to four trivalent aromatic amines through amide groups. The cage is tetrahedral in shape and similar in size to small proteins (Mw=8637 g/mol) with a spacious nonpolar interior for accommodating multiple guests. While 24 carboxylates at the outer surface of CBC‐11 render it soluble in aqueous phosphate buffer (PBS) at pH=7.0, the amphiphilic nature prompts its assembly into nanoparticles (d=250 nm, DLS). Cryo‐TEM examination of nanoparticles revealed their crystalline nature with wafer‐like shapes and hexagonally arranged cages. Nanoparticulate CBC‐11 traps anticancer drugs irinotecan and doxorubicin, with each cage binding up to four drug molecules in a non‐cooperative manner. The inclusion complexation resulted in nanoparticles growing in size and precipitating. In media containing mammalian cells (HCT 116, human colon carcinoma), the IC50 value of CBC‐11 was above 100 μM. While this work presents the first example of a large covalent organic cage operating in water at the physiological pH and forming crystalline nanoparticles, it also demonstrates its biocompatibility and potential to act as a polyvalent binder of drugs for their sequestration or delivery.
Alleviating Side Reactions on Zn Anodes for Aqueous Batteries by a Cell Membrane Derived Phosphorylcholine Zwitterionic Protective Layer
Authors: Meng Zhen , Jiao Yucong , Wu Peiyi 
Published: June 2023

AbstractAqueous zinc (Zn) ion batteries are attractive for next generation batteries with high safety, yet their applications are still hindered by the uncontrollable dendrite formation and side reactions on Zn anode. Here, a polyzwitterion protective layer (PZIL) was engineered by polymerizing 2‐methacryloyloxyethyl phosphorylcholine (MPC) in carboxymethyl chitosan (CMCS), which renders the following merits: the choline groups of MPC can preferentially adsorb onto Zn metal to avoid side reactions; the charged phosphate groups chelate with Zn2+ to regulate the solvation structure, further improving side reaction inhibition; the Hofmeister effect between ZnSO4 and CMCS can enhance the interfacial contact during electrochemical characterization. Consequently, the symmetrical Zn battery with PZIL can keep stable for more than 1000 hours under the ultra‐high current density of 40 mA cm−2. The PZIL confers the Zn/MnO2 full battery and Zn/active carbon (AC) capacitor with stable cycling performance under high current density.
Harmonious Heterointerfaces Formed on 2D‐Pt Nanodendrites by Facet‐Respective Stepwise Metal Deposition for Enhanced Hydrogen Evolution Reaction
Authors: Gu Byeong Su , Dutta Soumen , Hong Yu‐Rim , Ngome Okello Odongo Francis , Im Hyeonae , Ahn Seungil , Choi Si‐Young , Woo Han Jeong , Ryu Sunmin , Lee In Su 
Published: June 2023

AbstractThe performance of nanocrystal (NC) catalysts could be maximized by introducing rationally designed heterointerfaces formed by the facet‐ and spatio‐specific modification with other materials of desired size and thickness. However, such heterointerfaces are limited in scope and synthetically challenging. Herein, we applied a wet chemistry method to tunably deposit Pd and Ni on the available surfaces of porous 2D−Pt nanodendrites (NDs). Using 2D silica nanoreactors to house the 2D‐PtND, an 0.5‐nm‐thick epitaxial Pd or Ni layer (e‐Pd or e‐Ni) was exclusively formed on the flat {110} surface of 2D−Pt, while a non‐epitaxial Pd or Ni layer (n‐Pd or n‐Ni) was typically deposited at the {111/100} edge in absence of nanoreactor. Notably, these differently located Pd/Pt and Ni/Pt heterointerfaces experienced distinct electronic effect to influence unequally in electrocatalytic synergy for hydrogen evolution reaction (HER). For instance, an enhanced H2 generation on the Pt{110} facet with 2D‐2D interfaced e‐Pd deposition and faster water dissociation on the edge‐located n‐Ni overpowered their facet‐located counterparts in respective HER catalysis. Therefore, a feasible assembling of the valuable heterointerfaces in the optimal 2D n‐Ni/e‐Pd/Pt catalyst overcame the sluggish alkaline HER kinetics, with a catalytic activity 7.9 times higher than that of commercial Pt/C.
Influence of Molecular Separation on Through‐Space Intervalence Transient Charge Transfer in Metal–Organic Frameworks with Cofacially arranged Redox Pairs
Authors: Nath Akashdeep , Kumar Vikas , Shukla Ayushi , Ghosh Hirendra Nath , Mandal Sukhendu 
Published: June 2023

AbstractWe demonstrate direct evidence of photoinduced through‐space intervalence charge transfer (IVCT) between two cofacially arranged redox‐active pairs in metal–organic frameworks and their dynamic variation with their molecular separation. Two homologous MOFs [Co2(NDC)2(DPTTZ)2]. DPTTZ. DMF, 1 and [Co2(BDC)2(DPTTZ)2]. DMF, 2 (where NDC=naphthalene dicarboxylate, BDC=benzene dicarboxylate, DPTTZ=N, N′‐di(4‐pyridyl)thiazolo‐[5,4‐d]thiazole, DMF=N, N′‐dimethyl formamide) are considered for this, whose intra‐dimer distance of redox‐active DPTTZ ligands differs ca. 1 Å from one system to another. Spectroelectrochemical study detects the formation of IVCT band at the NIR region between cofacially oriented DPTTZ molecules in both MOFs. Transient spectroscopy shows faster charge separation as well as charge recombination when intra‐dimer distance is lesser (in MOF 2) due to stronger electronic coupling. We quantify the extent of IVCT by charge transfer integral calculation; and also by optical pump terahertz probe spectroscopy, where MOF 2 shows three times higher carrier mobility due to lesser inter‐DPTTZ distance than MOF 1. These findings reveal a more localized aspect of through‐space IVCT between cofacially organized redox‐active pair in a three‐dimensional framework.
Production of sugars from mixed hardwoods for use in the synthesis of sugar fatty acid esters catalyzed by immobilized‐stabilized derivatives of Candida antarctica lipase B
Authors: Gonçalves Maria Carolina Pereira , Cansian Ana Bárbara Moulin , Tardioli Paulo Waldir , Saville Bradley A. 
Published: June 2023

AbstractThe synthesis of sugar fatty acid esters (SFAEs) from lignocellulosic biomass and oleic acid (C18:1) was catalyzed by immobilized‐stabilized derivatives of Candida antarctica lipase B in a methyl ethyl ketone medium. After steam‐explosion pretreatment of mixed hardwoods and enzymatic hydrolysis at 15%wt solids, xylose and glucose were purified/concentrated to a mass ratio of ~3 to 1. These lignocellulosic sugars were superior to commercial sugars as the carbohydrate source for the esterification reaction in terms of sugar conversions. The highest conversions were obtained using 1.5% w/v of Novozyme 435 (N435, uncoated) as the biocatalyst for the synthesis of SFAEs. Coating the N435 with polyethyleneimine (PEI) prevented enzyme leakage into the reaction medium and produced 35% and 50% higher xylose and glucose conversions to SFAEs, respectively, at the same enzyme loading. After six 24 h reuse cycles with the PEI‐coated N435, xylose conversion decreased by 44%, while a 65% reduction in xylose conversion was observed with the uncoated lipase. Mass spectrometry analysis confirmed the production of xylose and glucose mono‐ and di‐esters. Our purified product presented an emulsion capacity (EC) close to that of a commercial sugar ester and the ECs of the xylose oleate, laurate, and palmitate synthesized in previous studies. © 2023 The Authors. Biofuels, Bioproducts and Biorefining published by Society of Industrial Chemistry and John Wiley & Sons Ltd.
Three‐dimensional spheroid formation of adipose‐derived stem cells improves the survival of fat transplantation by enhance their therapeutic effect
Authors: He Yucang , Zhang Zikai , Li Zihao , Lin Ming , Ding Siqi , Wu Hanwen , Yang Fangfang , Cai Zhongming , Li Tian , Wang Jingping , Ke Chen , Pan Shengsheng , Li Liqun 
Published: June 2023

AbstractAdipose‐derived stem cells (ADSCs) have important applications in basic research, especially in fat transplantation. Some studies have found that three‐dimensional (3D) spheroids formed by mesenchymal stem cells have enhanced therapeutic potential. However, the fundamental basics of this effect are still being discussed. ADSCs were harvested from subcutaneous adipose tissues and 3D spheroids were formed by the automatic aggregation of ADSCs in a non‐adhesive 6‐well plate. Oxygen glucose deprivation (OGD) was used to simulate the transplantation microenvironment. We found that 3D culture of ADSCs triggered cell autophagy. After inhibiting autophagy by Chloroquine, the rates of apoptosis were increased. When the 3D ADSC‐spheroids were re‐planked, the number of senescent ADSCs decreased, and the proliferation ability was promoted. In addition, there were more cytokines secreted by 3D ADSC‐spheroids including VEGF, IGF‐1, and TGF‐β. After adding the conditioned medium with human umbilical vein endothelial cells (HUVECs), 3D ADSC‐spheroids were more likely to promote migration, and tube formation, stimulating the formation of new blood vessels. Fat grafting experiments in nude mice also showed that 3D ADSC‐spheroids enhanced survival and neovascularization of fat grafts. These results suggested that 3D spheroids culturing of ADSCs can increase the therapeutic potential in fat transplantation.
A protocol for tactile function assessment using JVP domes: Feasibility study and preliminary results
Authors: Wang Yung‐Jung , Sung Chung‐Tung , Huang Jian‐Jia , Pei Yu‐Cheng , Chang Bao‐Luen 
Published: June 2023

AbstractBackgroundTouch is a crucial sense for perceiving the spatial characteristics of objects. The JVP dome was developed to evaluate tactile spatial acuity using a grating orientation task. There were few studies depicting sequences and details for the entire task, including practice, training, and testing sessions. Therefore, we proposed and elaborated a protocol for the grating orientation task using the staircase method, which required fewer testing trials compared with the method of constant stimuli.MethodsTwenty‐three healthy participants were enrolled in this experiment. The JVP domes with 11 different groove widths were used. Tactile discrimination thresholds were estimated using a two‐down‐one‐up staircase method. The experiment comprised practice, training, and testing sessions, conducted by trained examiners who performed grating stimulation on participants’ index fingerpads.ResultsAll participants passed the required accuracy in the practice and training sessions. Eight transition points were obtained in the testing session for each participant. The tactile discrimination thresholds were determined from the last six transition points. We obtained the mean tactile discrimination threshold as 1.8 ± 0.75 mm (n = 23). The results demonstrated that the proposed protocol was successfully applied to assess tactile discrimination thresholds.ConclusionsThe present study investigated the protocol of grating orientation tasks requiring a small number of testing trials with the assurance of the task quality. The feasibility study and preliminary results indicated the potentiality of this protocol for future clinical application.
Attitudes moralization and outgroup dehumanization in the dynamic between pro‐ vs. anti‐vaccines against COVID‐19
Authors: Ballone Chiara , Pacilli Maria Giuseppina , Teresi Manuel , Palumbo Riccardo , Pagliaro Stefano 
Published: June 2023

AbstractAttitudes towards socially sensitive topics tend to be polarized and moralized. Literature showed that in the political arena people tend to consider their group different from the outgroup in moral terms, and how this perceived distance is capable of producing discrimination against the outgroup. In light of this evidence, the aim of this study (N = 234) was to examine the dynamics between Pro‐vaxers and No‐vaxers in relation to the SARS‐COV‐2 vaccine. Participants evaluated the strength of their attitude towards the COVID‐19 vaccine, and the extent to which this attitude was moralized. They reported the perceived moral distance between the ingroup and the outgroup and completed a scale of outgroup animalistic dehumanization. Results showed a positive association between the strength of the attitude towards the vaccine and its moralization. The tendency to moralize the attitude was positively associated with the perception of moral distance between ingroup and outgroup, and this positively associated with the outgroup dehumanization. A sequential mediation model showed an indirect effect that links attitude strength to dehumanization through attitude moralization and the perception of moral distance between groups. Results are discussed in the light of recent theories on the moralization of attitudes and its importance in institutional communication. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Photoinduced Ring‐Opening and Phototoxicity of an Indolin‐3‐one Derivative
Authors: Doloczki Susanne , Kern Christoph , Holmberg Karl O. , Swartling Fredrik J. , Streuff Jan , Dyrager Christine 
Published: June 2023

AbstractThe study of a fluorescent indolin‐3‐one derivative is reported that, as opposed to its previously described congeners, selectively undergoes photoactivated ring‐opening in apolar solvents. The excited state involved in this photoisomerization was partially deactivated by the formation of singlet oxygen. Cell studies revealed lipid droplet accumulation and efficient light‐induced cytotoxicity.