bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Multiple Myeloma to Acute Myeloid Leukemia: A Case Report of a
61-year-old Woman after 8 Years of Chemotherapy and Immunotherapy
Authors: Fu Xue-Hang , Guan Rong-Yan , Huang Zoufang , Li Yun , Lu Guang , Mou Wei-Wei , Du Jun 
Published: June 2023

Background:
As the second most prevalent hematologic malignancy, multiple myeloma
(MM) affects plasma cells and is characterized by chromosomal abnormalities, particularly
involving the immunoglobulin heavy chain switch region. MM represents a biologically and clinically
heterogeneous hematological malignancy that serves as a clonal evolution model, exhibiting
clonal heterogeneity throughout all stages from monoclonal gammopathy undetermined significance
(MGUS) and smoldering multiple myeloma (SMM) to MM. Although significant progress
has been made in the treatment of MM, leading to improved patient outcomes, concerns are arising
regarding disease relapse due to the presence and selection of pre-existing resistant clones or
selective pressure during therapy.

Case Presentation:
We present a case of multiple myeloma (MM) in a female patient, who underwent
an 8-year course of treatment, including chemotherapy, immunomodulators, hematopoietic
stem cell transplantation, CD38 monoclonal antibody, and chimeric antigen receptor T-cell
(CAR-T), and was recently diagnosed with concurrent progressive MM and acute myeloid leukemia
(AML). This patient has witnessed the evolution of MM treatment paradigms.

Conclusion:
In this course, disease relapses occurred twice, one of which was manifested by a
light chain escape (LCE). Moreover, through the course of the disease in this patient, we review
the process of clonal evolution that may be relevant.
Navigated Transcranial Magnetic Stimulation (nTMS) based Preoperative
Planning for Brain Tumor Treatment
Authors: Riaz Hammad , Uzair Mohammad , Arshad Muhammad , Hamza Ali , Bukhari Nedal , Azam Faisal , Bashir Shahid 
Published: June 2023

Abstract:
Transcranial Magnetic Stimulation (TMS) is a non-invasive technique for analyzing the
central and peripheral nervous system. TMS could be a powerful therapeutic technique for neurological
disorders. TMS has also shown potential in treating various neurophysiological complications,
such as depression, anxiety, and obsessive-compulsive disorders, without pain and analgesics. Despite
advancements in diagnosis and treatment, there has been an increase in the prevalence of brain cancer
globally. For surgical planning, mapping brain tumors has proven challenging, particularly those localized
in expressive regions. Preoperative brain tumor mapping may lower the possibility of postoperative
morbidity in surrounding areas. A navigated TMS (nTMS) uses magnetic resonance imaging
(MRI) to enable precise mapping during navigated brain stimulation. The resulting magnetic impulses
can be precisely applied to the target spot in the cortical region by employing nTMS. This review focuses
on nTMS for preoperative planning for brain cancer. This study reviews several studies on TMS
and its subtypes in treating cancer and surgical planning. nTMS gives wider and improved dimensions
of preoperative planning of the motor-eloquent areas in brain tumor patients. nTMS also predicts postoperative
neurological deficits, which might be helpful in counseling patients. nTMS have the potential
for finding possible abnormalities in the motor cortex areas.
Genetic Diversity of Salvia Officinalis L. (Lamiaceae) and its Related Species using TU-DAMD Analysis
Authors: Saleh Basel 
Published: June 2023

Background:
Salvia tomentosa Mill., Salvia fruticosa Mill., and Salvia officinalis L. are Mediterranean species with different pharmaceutical and medicinal applications. However, genetic relationships among these species are still unclear.

Objective:
The study aimed to investigate the genetic polymorphism among S. officinalis L. (SO) and its related species S. tomentosa Mill. (ST) and S. fruticosa Mill. (SF) collected from different geographical regions in Syria.

Methods:
Touch-up directed amplification of minisatellite DNA (TU-DAMD) assay has been employed to assess genetic relationships among the studied Salvia species based on the estimated percent disagreement values (PDV).

Results:
Seventeen DAMD primers highlighted a mean of 90.419, 0.254, and 2.398% for polymorphism level (P%), polymorphic information content (PIC), and marker index (MI) values, respectively, across the three studied Salvia species. Unweighted Pair Group Mean Arithmetic average (UPGMA) analysis revealed that the studied Salvia samples were clustered into three main clusters; each species was split into one cluster. Overall, moderate P% of 72.662 and 70.374% was recorded for SO and ST species, respectively. Whereas, low P% of 51.429% was recorded for SF species.

Conclusion:
TU-DAMD marker is a potential tool for studying genetic relationships among the three studied Salvia species.
Strategies to Improve Access to Mental Health and Psychosocial
Support Among Displaced Populations in Ethiopia
Authors: Greene M. Claire , Getz Mara , Streicker Eleanor , Thind Priyam , Tayama Eri , Lafto Kinfu Manzura , Ayele Noah Wubishet , Worku Tinsae Abera , Carson Ryan , d'Andon Cécile Fanton , Yilma Tesfahun , Wainberg Milton , Fufa Yaregal , Firew Tsion 
Published: June 2023

Background:
In 2021, more than 23 million people were in need of humanitarian
assistance in Ethiopia, including four million internally displaced persons and returnees. Displaced
populations face an elevated risk of mental health and psychosocial problems, yet they
often have limited access to mental health and psychosocial support.

Objective:
This study aimed to assess: 1) the mental health and psychosocial needs and resources
among displaced persons in Ethiopia; and 2) examine barriers, and facilitators, and
identify strategies to improve access to culturally appropriate mental health and psychosocial
support in this population and context.

Methods:
We conducted a sequential mixed-methods assessment of mental health and psychosocial
needs and resources. First, we conducted 16 key informant interviews with those who
had experience and knowledge regarding the mental health situation of displaced persons in
Ethiopia, including mental health providers and humanitarian practitioners. Second, we conducted
an assessment of available mental health services in 15 internally displaced persons
(IDP) sites in Ethiopia along with 28 key informant interviews in this context to explore some
of the challenges and strategies to improving access to mental health and psychosocial support.

Results:
Access to mental health services was limited in IDP sites. Participants identified numerous
barriers to accessing services that ranged from limited supply and fragmentation of
existing mental health services to an incongruence between formal mental health services and
explanatory models of mental illness. Strategies to address these barriers included engagement
of community members and key stakeholders (e.g., traditional and religious healers), improving
mental health literacy, strengthening referral systems and mental health capacity, and improving
coordination and integration of mental health within the national health system.

Conclusion:
This study highlights several challenges and opportunities for improving access to
mental health and psychosocial support among displaced persons in Ethiopia. Efforts to bridge
gaps in access to mental health and psychosocial support must consider both systems-level
factors that influence availability as well as community factors influencing perceptions and
acceptability of services within this context.
Evaluation of the use of e-learning in the implementation of the "Stake's countenance" model in the era of the Covid 19 pandemic
Authors: Retnowati Trie Hartiti , Kuswarsantyo Kuswarsantyo , Prihadi Bambang , Wulandari Aldia , Alya Winny Chrisan , Rafika Tria 
Published: June 2023

The learning process in the Master of Arts Education Study Program during the Covid-19 pandemic experienced problems not being able to hold meetings offline. The purpose of the study was to evaluate the use of e-learning with a countenance stake model. This research uses a qualitative evaluation method with a countenance evaluation model by Stake. Matters evaluated include (1) Antecedent (context, input); (2) Transactions (processes) and (3) Outcomes (results) of curriculum implementation. The results showed that learning in the Master of Arts Education Study Program during the Covid-19 pandemic went smoothly. A total of 21.57% of the smooth learning process has the category of mostly smooth meetings. The suitability of student learning outcomes with CPL was 88.46%. CPL Based on the results of the questionnaire, data was obtained that the achievement of appropriate student learning outcomes (80-100%) was 83.33%. These results illustrate that student learning outcomes are fulfilling the aspect of achievement. Keywords: Art learning, evaluation, countenance stake Evaluasi pemanfaatan e-learning dalam pelaksanaan pembelajaran dengan model “countenance stake” di era pandemi Covid 19AbstrakProses pembelajaran di Program Studi Magister Pendidikan Seni masa pandemi covid-19 mengalami kendala tidak bisa melakukan pertemuan secara luring. Tujuan penelitian untuk mengevaluasi penggunaan e-learning dengan model countenance stake. Penelitian ini menggunakan metode evaluasi kualitatif dengan model countenance evaluation oleh Stake. Hal-hal yang di evaluasi meliputi (1) Antecedent (konteks, input); (2) Transaction (proses) dan (3) Outcomes (hasil) pelaksanaan kurikulum. Hasil penelitian menunjukkan bahwa pembelajaran di Program Studi Magister Pendidikan Seni masa pandemi covid-19 berjalan lancar. Sejumlah 21,57% kelancaran proses pembelajaran memiliki kategori sebagian besar pertemuan lancar. Kesesuaian hasil belajar mahasiswa dengan CPL sebesar 88,46%. CPL Berdasarkan hasil angket diperoleh data bahwa ketercapaian hasil belajar mahasiswa yang sesuai (80-100%) sejumlah 83,33%. Hasil tersebut menggambarkan hasil belajar mahasiswa terlah memenuhi aspek ketercapaian. Kata Kunci: Pembelajaran Seni, evaluasi, countenance stake
The development of assessment instrument for the Gambyong Pareanom dance practice
Authors: Rumiwiharsih Rumiwiharsih 
Published: June 2023

This study aims to develop an assessment instrument for the Gambyong Pareanom dance for students of the Dance Arts Education Study Program, Faculty of Languages and Arts of Yogyakarta State University, to find out the effectiveness of the Surakarta style Gambyong Pareanom dance assessment instrument. This was a research and development study with the DDD-E model by Borg Gall consisting of several development stages, including planning, design, and development, initial product trial, initial product revision, final product revision, operational product revision, and operational product trial. This research and development study involved 30 students of the Dance Arts Education Study Program, Faculty of Languages and Arts of Yogyakarta State University. The planning stage includes a needs analysis study and formulating these needs in a development plan. The planning involved several Javanese dance lecturers in Surakarta. This planning stage was carried out by determining the scope, identifying the characteristics of learning/students, determining product limitations, and making planning documents. The second stage, namely the design stage, includes making the design of the Gambyong Dance practice assessment model, which consists of aspects of assessment (attitudes, knowledge, and skills) in accordance with the learning outcomes of the Surakarta Female Dance course. The third stage, which is development, includes initial product trial, initial product revision, final product trial, and operational product trial. The effectiveness of the model was assessed based on the percentage of lecturers’ satisfaction on the Surakarta dance course, with the Gambyong Pareanom dance material based on the results of product trial. The results of the study show that the product is an assessment sheet which includes aspects of: 1) pacak, 2) pancat, 3) ulat, 4) lulut, 5) wiled, 6) luwes, 7) wirama, and 8) gendhing, all of which referred to as Hasta Sawanda. Two other aspects (wiraga and wirasa) are added, resulting in a total of ten assessment aspects. The effectiveness of the product shows that this assessment sheet is good for assessing the Gambyong Pareanom dance. Keywords: development, instrument, assessment, dance
Patient Satisfaction With a Multisite, Multiregional Remote Patient Monitoring Program for Acute and Chronic Condition Management: Survey-Based Analysis
Authors: Haddad Tufia C , Maita Karla C , Inselman Jonathan W , Avila Francisco R , Torres-Guzman Ricardo A , Coffey Jordan D , Christopherson Laura A , Leuenberger Angela M , Bell Sarah J , Pahl Dominick F , Garcia John P , Manka Lukas , Forte Antonio J , Maniaci Michael J 
Published: June 2023

Background
Remote patient monitoring (RPM) is an option for continuously managing the care of patients in the comfort of their homes or locations outside hospitals and clinics. Patient engagement with RPM programs is essential for achieving successful outcomes and high quality of care. When relying on technology to facilitate monitoring and shifting disease management to the home environment, it is important to understand the patients’ experiences to enable quality improvement.

Objective
This study aimed to describe patients’ experiences and overall satisfaction with an RPM program for acute and chronic conditions in a multisite, multiregional health care system.

Methods
Between January 1, 2021, and August 31, 2022, a patient experience survey was delivered via email to all patients enrolled in the RPM program. The survey encompassed 19 questions across 4 categories regarding comfort, equipment, communication, and overall experience, as well as 2 open-ended questions. Descriptive analysis of the survey response data was performed using frequency distribution and percentages.

Results
Surveys were sent to 8535 patients. The survey response rate was 37.16% (3172/8535) and the completion rate was 95.23% (3172/3331). Survey results indicated that 88.97% (2783/3128) of participants agreed or strongly agreed that the program helped them feel comfortable managing their health from home. Furthermore, 93.58% (2873/3070) were satisfied with the RPM program and ready to graduate when meeting the program goals. In addition, patient confidence in this model of care was confirmed by 92.76% (2846/3068) of the participants who would recommend RPM to people with similar conditions. There were no differences in ease of technology use according to age. Those with high school or less education were more likely to agree that the equipment and educational materials helped them feel more informed about their care plans than those with higher education levels.

Conclusions
This multisite, multiregional RPM program has become a reliable health care delivery model for the management of acute and chronic conditions outside hospitals and clinics. Program participants reported an excellent overall experience and a high level of satisfaction in managing their health from the comfort of their home environment.
Mindfulness-Based Mobile Apps and Their Impact on Well-Being in Nonclinical Populations: Systematic Review of Randomized Controlled Trials
Authors: Schwartz Katrin , Ganster Fabienne Marie , Tran Ulrich S 
Published: June 2023

Background
Mindfulness-based mobile apps have become popular tools for enhancing well-being in today’s fast-paced world. Their ability to reduce geographical, financial, and social barriers makes them a promising alternative to traditional interventions.

Objective
As most available apps lack a theoretical framework, this review aimed to evaluate their effectiveness and assess their quality. We expected to find small sample sizes, high dropout rates, and small effect sizes in the included studies.

Methods
A systematic literature search was conducted using PsycInfo, PsycNet, PubMed, an institutional search engine (u:search), and Google Scholar. Randomized controlled trials assessing the impact of mobile mindfulness apps on well-being in nonclinical samples were included. Study selection, risk of bias (using the version 2 of the Cochrane risk-of-bias tool for randomized trials), and reporting quality (using selected CONSORT [Consolidated Standards of Reporting Trials] statement criteria) assessments were performed by 2 authors independently and discussed until a consensus was reached.

Results
The 28 included randomized controlled trials differed in well-being measures, apps, and intervention duration (7 to 56 days; median duration 28 days). A wide range of sample sizes (12 to 2282; median 161) and attrition rates (0% to 84.7%; median rate 23.4%) were observed. Most studies (19/28, 68%) reported positive effects on at least one aspect of well-being. The effects were presented using different metrics but were primarily small or small to medium in size. Overall risk of bias was mostly high.

Conclusions
The wide range of sample sizes, attrition rates, and intervention periods and the variation in well-being measures and mobile apps contributed to the limited comparability of the studies. Although most studies (16/28, 57%) reported small or small to medium effects for at least one well-being outcome, this review demonstrates that the generalizability of the results is limited. Further research is needed to obtain more consistent conclusions regarding the impact of mindfulness-based mobile apps on well-being in nonclinical populations.
Perceived Use Cases, Barriers, and Requirements for a Smart Health-Tracking Toilet Seat: Qualitative Focus Group Study
Authors: Hermsen Sander , Verbiest Vera , Buijs Marije , Wentink Eva 
Published: June 2023

Background
Smart bathroom technology offers unrivaled opportunities for the automated measurement of a range of biomarkers and other data. Unfortunately, efforts in this area are mostly driven by a technology push rather than market pull approach, which decreases the chances of successful adoption. As yet, little is known about the use cases, barriers, and desires that potential users of smart bathrooms perceive.

Objective
This study aimed to investigate how participants from the general population experience using a smart sensor-equipped toilet seat installed in their home. The study contributes to answering the following questions: What use cases do citizens see for this innovation? and What are the limitations and barriers to its everyday use that they see, including concerns regarding privacy, the lack of fit with everyday practices, and unmet expectations for user experience?

Methods
Overall, 31 participants from 30 households participated in a study consisting of 3 (partially overlapping) stages: sensitizing, in which participants filled out questionnaires to trigger their thoughts about smart bathroom use and personal health; provotyping, in which participants received a gentle provocation in the form of a smart toilet seat, which they used for 2 weeks; and discussion, in which participants took part in a web-based focus group session to discuss their experiences.

Results
Participants mostly found the everyday use of the toilet, including installation and dismantling when necessary, to be relatively easy and free of complications. Where complications occurred, participants mentioned issues related to the design of the prototype, technology, or mismatches with normal practices in using toilets and hygiene. A broad range of use cases were mentioned, ranging from signaling potentially detrimental health conditions or exacerbations of existing conditions to documenting physical data to measuring biomarkers to inform a diagnosis and behavioral change. Participants differed greatly in whether they let others use, or even know about, the seat. Ownership and control over their own data were essential for most participants.

Conclusions
This study showed that participants felt that a smart toilet seat could be acceptable and effective, as long as it fits everyday practices concerning toilet use and hygiene. The range of potential uses for a smart toilet seat is broad, as long as privacy and control over disclosure and data are warranted.
Influence of durability of waterproofing solutions terraces protecting against water and moisture
Authors: Barbara Francke  , Leonard Runkiewicz  
Published: June 2023

The article analyses the changes in the durability of waterproofing of terraces, with particular emphasis on the properties of waterproofing materials as a result of utility factors. It was analysed the influence of tensile properties of the above-mentioned materials on their resistance against fatigue resulting from movements of the substrates caused by temperature changes on the surface of the terraces coverings. The adopted range of horizontal plate movements was from 0 to 2 mm at variable temperatures: – 15°C and +70°C. The durability of waterproofing sheets, such as reinforced bitumen sheets and PVC sheets and rubber sheets, as well as coating products was assessed. Thermal deformations of the substrate plates occurring within the terrace covering are most effectively transferred by flexibility sheets with a high relative elongation value, that is: bitumen sheets with polyester reinforcement, PVC sheets and EPDM sheets. The correlation between the mechanical properties of the coatings and their resistance to fatigue cannot be determined but the most favourable properties are shown by two-component (polymer-cement) liquid applied water impermeable products reinforced on the entire surface or reinforced with special tapes over the thermal expansion joints of the substrate plates.
Public Communication of Audit Risks and Related-Party Transactions: Evidence from China
Authors: Hope Ole-Kristian , Yue Heng , Zhong Qinlin 
Published: June 2023

SUMMARY
This paper examines whether and how firms’ engagement in related-party transactions (RPTs) is shaped by public communication of audit risks as required by the expanded audit report. Using the phased regulatory changes in China and a difference-in-differences design with firm fixed effects and matching, we find that firms significantly reduce their RPTs after the adoption of expanded audit reports (EARs). To investigate potential mechanisms, we find that (1) investor scrutiny increases after the adoption of EARs, (2) the reduction of RPTs is more pronounced when EARs are more likely to attract investor attention, and (3) the reduction of RPTs is weaker when firms are less concerned about investor scrutiny. The results suggest that EARs can attract investor scrutiny and increase the possible penalty associated with self-dealing, thus motivating firms to reduce RPTs.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: G30; G34; G38; M10; M16; M40; M41; M42: M48.