bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased noise levels cause behavioural and distributional changes in Atlantic cod and saithe in a large public aquarium—A case study
Authors: Andersson Marica , Svensson Ola , Swartz Terese , Manera Jack L. , Bertram Michael G. , Blom Eva‐Lotta 
Published: August 2023

AbstractInvestigating the effects of underwater noise on aquatic animals is a research field that is receiving rapidly increasing attention. Despite this, surprisingly few studies have addressed the potential impacts of noise in a marine animal husbandry setting. In this regard, the behaviour of fish in public aquariums can be used as an indicator of well‐being, and noise is known to cause behavioural changes. This case study investigates the behaviour of cod (Gadus morhua) and saithe (Pollachius virens) in a large public aquarium when exposed to increased noise levels originating from an aquarium renovation carried out by construction divers. Swimming behaviour, group formation and vertical distribution, along with yawning and scratching frequencies of the fish, were analysed from video recordings made before, during and after the exposure to increased noise levels. The same parameters were also analysed to evaluate potential effects of the presence of divers when not making renovation noise, compared to fish behaviour prior to the renovation. There was a slight change in the depth distribution of both species and a decrease in the number of scratches in cod due to the presence of divers that were not making renovation noise. In the presence of construction noises in the tank, however, both cod and saithe showed a wider array of behavioural changes, including increased swimming speed, changes in depth distribution and increased yawning frequencies. The results from this case study demonstrate that an underwater renovation with increased noise levels impacts fish behaviour and suggests that underwater noise should be considered during the management of aquatic environments, including public aquaria.
Clinical significance of mechanistic target of rapamycin expression in vessels that encapsulate tumor cluster‐positive hepatocellular carcinoma patients who have undergone living donor liver transplantation
Authors: Toshida Katsuya , Itoh Shinji , Toshima Takeo , Yoshiya Shohei , Goto Ryoichi , Mita Atsuyoshi , Harada Noboru , Kohashi Kenichi , Oda Yoshinao , Yoshizumi Tomoharu 
Published: August 2023

AbstractBackgroundThere is limited published information regarding the expression of mechanistic target of rapamycin (mTOR) in vessels that encapsulate tumor cluster (VETC)‐positive hepatocellular carcinoma (HCC). The mTOR inhibitor, everolimus, has been approved as an immunosuppressant for use in HCC patients after living donor liver transplantation (LDLT).MethodsUsing a database of 214 patients who underwent LDLT for HCC, we examined the mTOR protein and angiopoietin‐2 (Ang‐2) in VETC‐positive HCC by immunohistochemical staining. The presence of VETC and mTOR expression were evaluated in both primary and recurrent HCC lesions.ResultsForty‐three of the 214 patients (20.1%) were VETC‐positive, and 29 of these 43 patients (67.4%) expressed mTOR. Relative Ang‐2 expression was significantly higher in the mTOR‐positive than in the mTOR‐negative group (p = 0.037). Thirty‐four of the 214 patients experienced HCC recurrence after LDLT; 20 of these were operable. The primary lesions of six of these 20 patients were VETC‐positive; five of these six patients also had VETC‐positive recurrent lesions (p < 0.001). The expression of mTOR was significantly higher in the VETC‐positive lesions (p = 0.0018).ConclusionsWe showed that mTOR expression was higher in the VETC‐positive primary and recurrent lesions than in the VETC‐negative ones.
One‐dimensional molecular co‐crystal alloys capable of full‐color emission for low‐loss optical waveguide and optical logic gate
Authors: Qi Zhenhong , Ma Yu‐Juan , Yan Dongpeng 
Published: August 2023

AbstractThe luminescence color of molecule‐based photoactive materials is the key to the applications in lighting and optical communication. Realizing continuous regulation of emission color in molecular systems is highly desirable but still remains a challenge due to the individual emission band of purely organic molecules. Herein, a novel alloy strategy based on molecular co‐crystals is reported. By adjusting the molar ratio of pyrene (Py) and fluorathene (Flu), three types of molecular co‐crystal alloys (MCAs) assemblies are prepared involving Py‐Flu‐OFN‐x%, Py‐Flu‐TFP‐x%, Py‐Flu‐TCNB‐x%. Multiple energy level structure and Förster resonance energy transfer (FRET) process endow materials with tunable full‐spectra emission color in visible region. Impressively, these MCAs and co‐crystals can be successfully applied to low optical loss waveguide and optical logic gate by virtue of all‐color luminescence from blue across green to red, together with smooth surface of one‐dimensional microrods, which show promising applications as continuous light emitters for advance photonics applications.
Stroke‐Related Visceral Alterations: A Voxel‐Based Neuroanatomic Localization Study
Authors: Arsava Ethem Murat , Chang Ken , Tawakol Ahmed , Loggia Marco L. , Goldstein Joshua N. , Brown James , Park Kwang‐Yeol , Singhal Aneesh B. , Kalpathy‐Cramer Jayashree , Sorensen Alma Gregory , Rosen Bruce R. , Samuels Martin Allen , Ay Hakan 
Published: August 2023

ObjectiveFunctional and morphologic changes in extracranial organs can occur after acute brain injury. The neuroanatomic correlates of such changes are not fully known. Herein, we tested the hypothesis that brain infarcts are associated with cardiac and systemic abnormalities (CSAs) in a regionally specific manner.MethodsWe generated voxelwise p value maps of brain infarcts for poststroke plasma cardiac troponin T (cTnT) elevation, QTc prolongation, in‐hospital infection, and acute stress hyperglycemia (ASH) in 1,208 acute ischemic stroke patients prospectively recruited into the Heart–Brain Interactions Study. We examined the relationship between infarct location and CSAs using a permutation‐based approach and identified clusters of contiguous voxels associated with p < 0.05.ResultscTnT elevation not attributable to a known cardiac reason was detected in 5.5%, QTc prolongation in the absence of a known provoker in 21.2%, ASH in 33.9%, and poststroke infection in 13.6%. We identified significant, spatially segregated voxel clusters for each CSA. The clusters for troponin elevation and QTc prolongation mapped to the right hemisphere. There were 3 clusters for ASH, the largest of which was in the left hemisphere. We found 2 clusters for poststroke infection, one associated with pneumonia in the left and one with urinary tract infection in the right hemisphere. The relationship between infarct location and CSAs persisted after adjusting for infarct volume.InterpretationOur results show that there are discrete regions of brain infarcts associated with CSAs. This information could be used to bootstrap toward new markers for better differentiation between neurogenic and non‐neurogenic mechanisms of poststroke CSAs. ANN NEUROL 2023;94:1155–1163
Reversely Trapping Isolated Atoms in High Oxidation State for Accelerating the Oxygen Evolution Reaction Kinetics
Authors: Li Yang , Bo Tingting , Zuo Shouwei , Zhang Guikai , Zhao Xiaojuan , Zhou Wei , Wu Xin , Zhao Guoxiang , Huang Huawei , Zheng Lirong , Zhang Jing , Zhang Huabin , Zhang Jian 
Published: August 2023

AbstractDeveloping efficient electrocatalysts for the oxygen evolution reaction (OER) is paramount to the energy conversion and storage devices. However, the structural complexity of heterogeneous electrocatalysts makes it a great challenge to elucidate the dynamic structural evolution and OER mechanisms. Here, we develop a controllable atom‐trapping strategy to extract isolated Mo atom from the amorphous MoOx‐decorated CoSe2 (a‐MoOx@CoSe2) pre‐catalyst into Co‐based oxyhydroxide (Mo‐CoOOH) through an ultra‐fast self‐reconstruction process during the OER process. This conceptual advance has been validated by operando characterizations, which reveals that the initially rapid Mo leaching can expedite the dynamic reconstruction of pre‐catalyst, and simultaneously trap Mo species in high oxidation state into the lattice of in situ generated CoOOH support. Impressively, the OER kinetics of CoOOH has been greatly accelerated after the reverse decoration of Mo species, in which the Mo‐CoOOH affords a markedly decreased overpotential of 297 mV at the current density of 100 mA cm−2. Density functional theory (DFT) calculations demonstrate that the Co species have been greatly activated via the effective electron coupling with Mo species in high oxidation state. These findings open new avenues toward directly synthesizing atomically dispersed electrocatalysts for high‐efficiency water splitting.
Multiblock Copolymers Based on Highly Crystalline Polyethylene and Soft Poly(ethylene‐co‐butadiene) Segments: Towards Polyolefin Thermoplastic Elastomers
Authors: Langlais Marvin , Baulu Nicolas , Dronet Séverin , Dire Charlotte , Jean‐Baptiste‐dit‐Dominique François , Albertini David , D'Agosto Franck , Montarnal Damien , Boisson Christophe 
Published: August 2023

AbstractBlock copolymers based on polyethylene (PE) and ethylene butadiene rubber (EBR) were obtained by successive controlled coordinative chain transfer polymerization (CCTP) of a mixture of ethylene and butadiene (80/20) and pure ethylene. EBR‐b‐PE diblock copolymers were synthesized using the {Me2Si(C13H8)2Nd(BH4)2Li(THF)}2 complex in combination with n‐butyl,n‐octyl magnesium (BOMAG) used as both the alkylating and chain transfer agent (CTA). Triblock and multiblock copolymers featuring highly semi‐crystalline PE hard segments and soft EBR segments were further obtained by the development of a bimetallic CTA, the pentanediyl‐1,5‐di(magnesium bromide) (PDMB). These new block copolymers undergo crystallization‐driven organization into lamellar structures and exhibit a variety of mechanical properties, including excellent extensibility and elastic recovery in the case of triblock and multiblock copolymers.
Modulating the Reaction Configuration by Breaking the Structural Symmetry of Active Sites for Efficient Photocatalytic Reduction of Low‐concentration CO2
Authors: Lyu Wenyuan , Liu Yang , Zhou Jingyi , Chen Datong , Zhao Xin , Fang Ruiqi , Wang Fengliang , Li Yingwei 
Published: August 2023

AbstractPhotocatalytic conversion of low‐concentration CO2 is considered as a promising way to simultaneously mitigate the environmental and energy issues. However, the weak CO2 adsorption and tough CO2 activation process seriously compromise the CO production, due to the chemical inertness of CO2 molecule and the formed fragile metal‐C/O bond. Herein, we designed and fabricated oxygen vacancy contained Co3O4 hollow nanoparticles on ordered macroporous N‐doped carbon framework (Vo−HCo3O4/OMNC) towards photoreduction of low‐concentration CO2. In situ spectra and ab initio molecular dynamics simulations reveal that the constructed oxygen vacancy is able to break the local structural symmetry of Co−O−Co sites. The formation of asymmetric active site switches the CO2 configuration from a single‐site linear model to a multiple‐sites bending one with a highly stable configuration, enhancing the binding and structural polarization of CO2 molecules. As a result, Vo−HCo3O4/OMNC shows unprecedent activity in the photocatalytic conversion of low‐concentration CO2 (10 % CO2/Ar) under laboratory light source or even natural sunlight, affording a syngas yield of 337.8 or 95.2 mmol g−1 h−1, respectively, with an apparent quantum yield up to 4.2 %.
Platinum(II)‐Based Optical Probes for Imaging Quadruplex DNA Structures via Phosphorescence Lifetime Imaging Microscopy
Authors: Berrones Reyes Jessica , Sherin Peter S. , Sarkar Amrita , Kuimova Marina K. , Vilar Ramon 
Published: August 2023

AbstractG‐quadruplex DNA is a non‐canonical structure that forms in guanine‐rich regions of the genome. There is increasing evidence showing that G‐quadruplexes have important biological functions, and therefore molecular tools to visualise these structures are important. Herein we report on a series of new cyclometallated platinum(II) complexes which, upon binding to G‐quadruplex DNA, display an increase in their phosphorescence, acting as switch‐on probes. More importantly, upon binding to G‐quadruplexes they display a selective and distinct lengthening of their emission lifetime. We show that this effect can be used to selectively visualise these structures in cells using Phosphorescence Lifetime Imaging Microscopy (PLIM).
Polydopamine‐assisted in situ formation of dense aramid nanofibers layer on polyethylene separator for lithium‐ion battery
Authors: Cheng Feng , Qian Jingting , Li Hongbin , Di Jianwei , He Jinmei , Bai Yongping , Huang Yudong 
Published: August 2023

AbstractHerein, we report a modified polyethylene (PE) separators via in situ polymerization of polydopamine (PDA) and coating of dense aramid nanofibers (ANFs) on the surface of PE separator. Due to the unique hydrophilic performance and cooperative effect of PDA and ANFs, the wettability and migration ability of lithium ion of the modified PE separator were obviously enhanced. Moreover, the modified PE separator have the lower thermal shrinkage, the higher melting temperature and decomposition temperature, and excellently electrolyte wettability than pristine PE separators. The capacity of the modified PE separator remains 140.29 mAh g−1 after 200 cycles at 1.0°C, and the coulombic efficiency also maintain more than 78.86%. In addition, the modified PE separator exhibits a higher lithium‐ion transfer number, outstanding ionic conductivity (2.390 × 10−4 S/cm) and small interfacial resistance (−83.85 Ω) due to its excellently electrochemical properties. Thus, the modified PE separator has great potential to fabricate the high quality separator materials for designing and developing lithium‐ion batteries.
Mechanism research on the application of liquid film microencapsulation technology based on natural lotion in strengthening recycled bio‐composite wallpaper material
Authors: Xiao Dingtian , Chen Yuanhua , Bhutta Muhammad Shoaib , Yi Jiliang , Zhang Cheng , Li Tingpeng , Wang Xiangan 
Published: August 2023

AbstractLow‐carbon technology is currently one of the main research directions in sustainable research. The purpose of this research is to explore environmentally friendly low‐carbon technologies to apply NL and wastes to the development of bio‐composite. This research can not only inhibit the release of toxic atmosphere from composite wallpaper materials but also propose new perspective for recycling several bulk wastes such as agricultural waste, waste plastics, and waste cooking oil. This study not only conducted an exploratory research on the degree of filling load from a vertical perspective but also conducted comparative experiments to clarify the strengthening effect of NL in a horizontal perspective. Several valuable findings are obtained through the analysis of several measurements such as mechanical performance and scanning electron microscope (SEM) morphology. The heat transfer effect between components inside the bio‐composite is enhanced by the action of NL. A better heat transfer effect can prevent heat from accumulating in local areas of bio‐composite, resulting in an increase in the overall initial pyrolysis temperature of thermogravimetric analysis (TGA) curve. It is found through experiments that when the biomass filler is excessive, the mechanical performance of the sample sharply decreased. These negative phenomena are presented in the specific form of voids and aggregates in the internal structure of bio‐composite from a microscopic perspective. Comprehensive analysis manifested that NL can suppress the negative effect of filler agglomeration and strengthen the filler/matrix interface bonding. The research also found that the type of biomass filler can affect the actual effect of NL. These findings have certain academic significance and can promote the further development of sustainable research on diversified recycle of wastes.
Harnessing Nanomaterials for Enhanced Biohydrogen Generation from Wastewater
Authors: Ihsanullah I. , Bilal Muhammad , Tariq Khan Muhammad 
Published: August 2023

AbstractBiohydrogen is considered a green fuel due to its eco‐friendly nature since it only produces water and energy on combustion. However, their lower yield and production rate is one of the foremost challenges that need an instant sustainable approach. The use of nanotechnology is a potential approach for the enhanced generation of biohydrogen, owing to the significant characteristics of the nanomaterials such as greater specificity, high surface‐area‐to‐volume ratio, better reactivity and dispersibility, enhanced catalytic activity, superb selectivity, greater electron transfer, and better anaerobic microbiota activity. This article explores the recent trends and innovations in the production of biohydrogen from wastewater through the applications of different nanomaterials. The potential of various nanomaterials employed for biohydrogen production from wastewater is evaluated and the impacts of important parameters such as the concentration and size of the nanomaterials, temperature, and pH on the production and yield of biohydrogen are explained in detail. Several pathways involved in the mechanistic approach of biohydrogen generation from wastewater are critically assessed. Lastly, numerous technological challenges are highlighted and recommendations regarding future research are also provided.
Reactivity of Cyclic (Alkyl)(amino)germylene towards Copper(I) and Gold(I) Complexes
Authors: Feng Zhongtao , Wang Liliang , Mohammed Sharifah Nadhirah Binte Shaik , Rao Bin , Kinjo Rei 
Published: August 2023

AbstractThe reactions of cyclic (alkyl)(amino)germylenes (CAAGe) with copper(I) and gold(I) complexes were investigated. CAAGe (1) reacts with CuBr(SMe2) leading to a tetrameric germylene complex [CAAGeCuBr]4 (2), whereas CAAGe (3) undergoes Au−Cl bond insertion with LAuCl (L=phosphine or N‐heterocyclic carbene) to afford germanium gold(I) complexes (5 and 6). Chlorine abstraction of 6 gives the cationic germylene gold(I) complex 7.
An initial evaluation of staff injuries in human service organizations
Authors: Ruby Sandra A. , Wine Byron , Blackman Abigail L. , DiGennaro Reed Florence 
Published: August 2023

AbstractRecent data reveal an increase in the likelihood of staff injury for those working in the health care and social assistance industries (United States Bureau of Labor Statistics, 2021). Without information summarizing variables pertaining to staff injury in behavior‐analytic service settings, organizational leaders risk the safety of staff they employ. Despite the social relevance, few studies concerning the types of client‐related staff injuries have been published. The purpose of this survey was to gather data on the cause, type, bodily location of, and treatment required for staff injury by surveying organizations that serve individuals with autism spectrum disorder. Respondents ranked the leading cause of injury as client‐to‐staff interactions, type of injury as bite, location of injury as arm, and the most common treatment required as on‐site first aid. These initial data could assist in the identification of job tasks that may be associated with increased risk of injury, potential ramifications of client‐inflicted injuries on staff performance and organizational outcomes, and how to address injuries in settings within an injury‐prone industry. Implications and future research ideas are also discussed.
The role of intermolecular interactions on monoclonal antibody filtration through virus removal membranes
Authors: Billups Matthew , Minervini Mirko , Holstein Melissa , Feroz Hasin , Ranjan Swarnim , Hung Jessica , Zydney Andrew L. 
Published: August 2023

AbstractThe removal of viruses by filtration is a critical unit operation to ensure the overall safety of monoclonal antibody (mAb) products. Many mAbs show very low filtrate flux during virus removal filtration, although there are still significant uncertainties regarding both the mechanisms and antibody properties that determine the filtration behavior. Experiments were performed with three highly purified mAbs through three different commercial virus filters (Viresolve Pro, Viresolve NFP, and Pegasus SV4) with different pore structures and chemistries. The flux decline observed during mAb filtration was largely reversible, even under conditions where the filtrate flux with the mAb was more than 100‐fold smaller than the corresponding buffer flux. The extent of flux decline was highly correlated with the hydrodynamic diameter of the mAb as determined by dynamic light scattering (DLS). The mAb with the lowest filtrate flux for all three membranes showed the largest attractive intermolecular interactions and the greatest hydrophobicity, with the latter determined by binding to a butyl resin in an analytical hydrophobic interaction chromatography (HIC) column. These results strongly suggest that the flux behavior is dominated by reversible self‐association of the mAbs, providing important insights into the design of more effective virus filtration processes and in the early identification of problematic mAbs/solution conditions.
Increased RUNX3 expression mediates tumor‐promoting ability of human breast cancer‐associated fibroblasts
Authors: Koyama Yu , Okazaki Hiroya , Shi Yang , Mezawa Yoshihiro , Wang Zixu , Sakimoto Mizuki , Ishizuka Akane , Ito Yasuhiko , Koyama Takumi , Daigo Yataro , Takano Atsushi , Miyagi Yohei , Yokose Tomoyuki , Yamashita Toshinari , Sugahara Keisuke , Hino Okio , Yang Liying , Maruyama Reo , Katakura Akira , Yasukawa Takehiro , Orimo Akira 
Published: August 2023

AbstractBackgroundCancer‐associated fibroblasts (CAFs) are a major stromal component of human breast cancers and often promote tumor proliferation, progression and malignancy. We previously established an experimental CAF (exp‐CAF) cell line equipped with a potent tumor‐promoting ability. It was generated through prolonged incubation of immortalized human mammary fibroblasts with human breast cancer cells in a tumor xenograft mouse model.ResultsHerein, we found that the exp‐CAFs highly express Runt‐related transcription factor 3 (RUNX3), while counterpart fibroblasts do not. In breast cancer patients, the proportion of RUNX3‐positive stromal fibroblast‐like cells tends to be higher in cancerous regions than in non‐cancerous regions. These findings suggest an association of RUNX3 with CAF characteristics in human breast cancers. To investigate the functional role of RUNX3 in CAFs, the exp‐CAFs with or without shRNA‐directed knockdown of RUNX3 were implanted with breast cancer cells subcutaneously in immunodeficient mice. Comparison of the resulting xenograft tumors revealed that tumor growth was significantly attenuated when RUNX3 expression was suppressed in the fibroblasts. Consistently, Ki‐67 and CD31 immunohistochemical staining of the tumor sections indicated reduction of cancer cell proliferation and microvessel formation in the tumors formed with the RUNX3‐suppressed exp‐CAFs.ConclusionThese results suggest that increased RUNX3 expression could contribute to the tumor‐promoting ability of CAFs through mediating cancer cell growth and neoangiogenesis in human breast tumors.