bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial intelligence-based non-invasive tumor segmentation, grade stratification and prognosis prediction for clear-cell renal-cell carcinoma
Authors: Chen Siteng , Song Dandan , Chen Lei , Guo Tuanjie , Jiang Beibei , Liu Aie , Pan Xianpan , Wang Tao , Tang Heting , Chen Guihua , Xue Zhong , Wang Xiang , Zhang Ning , Zheng Junhua 
Published: August 2023

Abstract
Due to the complicated histopathological characteristics of clear-cell renal-cell carcinoma (ccRCC), non-invasive prognosis before operative treatment is crucial in selecting the appropriate treatment. A total of 126 345 computerized tomography (CT) images from four independent patient cohorts were included for analysis in this study. We propose a V Bottleneck multi-resolution and focus-organ network (VB-MrFo-Net) using a cascade framework for deep learning analysis. The VB-MrFo-Net achieved better performance than VB-Net in tumor segmentation, with a Dice score of 0.87. The nuclear-grade prediction model performed best in the logistic regression classifier, with area under curve values from 0.782 to 0.746. Survival analysis revealed that our prediction model could significantly distinguish patients with high survival risk, with a hazard ratio (HR) of 2.49 [95% confidence interval (CI): 1.13–5.45, P = 0.023] in the General cohort. Excellent performance had also been verified in the Cancer Genome Atlas cohort, the Clinical Proteomic Tumor Analysis Consortium cohort, and the Kidney Tumor Segmentation Challenge cohort, with HRs of 2.77 (95%CI: 1.58–4.84, P = 0.0019), 3.83 (95%CI: 1.22–11.96, P = 0.029), and 2.80 (95%CI: 1.05–7.47, P = 0.025), respectively. In conclusion, we propose a novel VB-MrFo-Net for the renal tumor segmentation and automatic diagnosis of ccRCC. The risk stratification model could accurately distinguish patients with high tumor grade and high survival risk based on non-invasive CT images before surgical treatments, which could provide practical advice for deciding treatment options.
GRAS family member LATERAL SUPPRESSOR regulates the initiation and morphogenesis of watermelon lateral organs
Authors: Jiang Yanxin , Zhang Anran , He Wenjing , Li Qingqing , Zhao Bosi , Zhao Hongjiao , Ke Xubo , Guo Yalu , Sun Piaoyun , Yang Tongwen , Wang Zheng , Jiang Biao , Shen Junjun , Li Zheng 
Published: August 2023

Abstract
The lateral organs of watermelon (Citrullus lanatus), including lobed leaves, branches, flowers, and tendrils, together determine plant architecture and yield. However, the genetic controls underlying lateral organ initiation and morphogenesis remain unclear. Here, we found that knocking out the homologous gene of shoot branching regulator LATERAL SUPPRESSOR in watermelon (ClLs) repressed the initiation of branches, flowers, and tendrils and led to developing round leaves, indicating that ClLs undergoes functional expansion compared with its homologs in Arabidopsis (Arabidopsis thaliana), rice (Oryza sativa), and tomato (Solanum lycopersicum). Using ClLs as the bait to screen against the cDNA library of watermelon, we identified several ClLs-interacting candidate proteins, including TENDRIL (ClTEN), PINOID (ClPID), and APETALA1 (ClAP1). Protein–protein interaction assays further demonstrated that ClLs could directly interact with ClTEN, ClPID, and ClAP1. The mRNA in situ hybridization assay revealed that the transcriptional patterns of ClLs overlapped with those of ClTEN, ClPID, and ClAP1 in the axillary meristems and leaf primordia. Mutants of ClTEN, ClPID, and ClAP1 generated by the CRISPR/Cas9 gene editing system lacked tendrils, developed round leaves, and displayed floral diapause, respectively, and all these phenotypes could be observed in ClLs knockout lines. Our findings indicate that ClLs acts as lateral organ identity protein by forming complexes with ClTEN, ClPID, and ClAP1, providing several gene targets for transforming the architecture of watermelon.
Superiority-Seeking and the Preference for Exclusion
Authors: Imas Alex , Madarász Kristof 
Published: August 2023

Abstract
We propose that a person’s desire to consume an object or possess an attribute increases in how much others want but cannot have it. We term this motive imitative superiority-seeking and show that it generates preferences for exclusion that help explain a host of market anomalies and make novel predictions in a variety of domains. In bilateral exchange, trade becomes more zero-sum, leading to an endowment effect. People’s value of consuming a good increases in its scarcity, which generates a motive for firms and organizations to engage in exclusionary policies. A monopolist producing at constant marginal cost can increase profits by randomly excluding buyers relative to the standard optimal mechanism of posting a common price. In the context of auctions, a seller can extract greater revenues by randomly barring a subset of consumers from bidding. Moreover, such non-price-based exclusion leads to higher revenues than the classic optimal sales mechanism. A series of experiments provides direct support for these predictions. In basic exchange, a person’s willingness to pay for a good increases as more people are explicitly barred from the opportunity to acquire it. In auctions, randomly excluding people from the opportunity to bid substantially increases bids amongst those who retain this option. Consistent with our predictions, exclusion leads to bigger gains in expected revenue than increasing competition through inclusion. Our model of superiority-seeking generates “Veblen effects,” rationalizes attitudes against redistribution and provides a novel motive for social exclusion and discrimination.
Sources and Transmission of Country Risk
Authors: Hassan Tarek A , Schreger Jesse , Schwedeler Markus , Tahoun Ahmed 
Published: August 2023

Abstract
We use textual analysis of earnings conference calls held by listed firms around the world to measure the amount of risk managers and investors at each firm associated with each country at each point in time. Flexibly aggregating this firm-country-quarter-level data allows us to systematically identify spikes in perceived country risk (“crises”) and document their source and pattern of transmission to foreign firms. While this pattern usually follows a gravity structure, it often changes dramatically during crises. For example, while crises originating in developed countries propagate disproportionately to foreign financial firms, emerging market crises transmit less financially and more to traditionally exposed countries. We apply our measures to show that elevated perceptions of a country’s riskiness, particularly those of foreign and financial firms, are associated with significant falls in local asset prices, capital outflows, and an increased likelihood of a sudden stop.
Radioactivity level evaluation in granite building raw material production area in Cenxi, China
Authors: Liu Zebin , Lu Hao , Wang Tianfu , Wang Shangwei , Liu Guanhua , Lai Wanchang 
Published: August 2023

Abstract
This study was conducted to evaluate the radioactivity level in the granite building raw material production area in Cenxi, China. Natural radionuclide concentrations, γ absorbed dose rates (ADRs) and radon exhalation rates were measured in the area. The spatial distribution of natural radionuclides, γ ADR and radon exhalation rate were mapped with GPS information. The radioactivity levels in the study area were analysed based on the descriptive statistics and frequency distribution of measurement data. According to the Chinese standard, the granite raw materials used for building and decoration in this region were classified based on their radiological hazards. In addition, radiation protection measures were proposed for the mining of local granite building materials products as well as environmental protection around the work area and resident safety.
Evaluation of neurotoxicity and the role of oxidative stress of cobalt nanoparticles, titanium dioxide nanoparticles, and multiwall carbon nanotubes in Caenorhabditis elegans
Authors: Chen Cheng , Chen Jingrong , Lin Xinpei , Yang Jiafu , Qu Huimin , Li Lisong , Zhang Duanyan , Wang Wei , Chang Xiangyu , Guo Zhenkun , Cai Ping , Yu Guangxia , Shao Wenya , Hu Hong , Wu Siying , Li Huangyuan , Bornhorst Julia , Aschner Michael , Zheng Fuli 
Published: August 2023

Abstract
The widespread use of nanomaterials in daily life has led to increased concern about their potential neurotoxicity. Therefore, it is particularly important to establish a simple and reproducible assessment system. Representative nanomaterials, including cobalt nanoparticles (CoNPs), titanium dioxide nanoparticles (TiO2-NPs), and multiwall carbon nanotubes (MWCNTs), were compared in terms of their neurotoxicity and underlying mechanisms. In 0, 25, 50, and 75 μg/ml of these nanomaterials, the survival, locomotion behaviors, acetylcholinesterase (AchE) activity, reactive oxygen species production, and glutathione-S transferase 4 (Gst-4) activation in wildtype and transgenic Caenorhabditis elegans (C. elegans) were evaluated. All nanomaterials induced an imbalance in oxidative stress, decreased the ratio of survival, impaired locomotion behaviors, as well as reduced the activity of AchE in C. elegans. Interestingly, CoNPs and MWCNTs activated Gst-4, but not TiO2-NPs. The reactive oxygen species scavenger, N-acetyl-l-cysteine, alleviated oxidative stress and Gst-4 upregulation upon exposure to CoNPs and MWCNTs, and rescued the locomotion behaviors. MWCNTs caused the most severe damage, followed by CoNPs and TiO2-NPs. Furthermore, oxidative stress and subsequent activation of Gst-4 were involved in nanomaterials-induced neurotoxicity. Our study provides a comprehensive comparison of the neurotoxicity and mechanisms of typical nanomaterials, which could serve as a model for hazard assessment of environmental pollutants using C. elegans as an experimental model system.
Mismatch between primary and secondary growth and its consequences on wood formation in Qinghai spruce
Authors: Yu Biyun , Rossi Sergio , Su Hongxin , Zhao Ping , Zhang Shaokang , Hu Baoqing , Li Xuebin , Chen Lin , Liang Hanxue , Huang Jian-Guo 
Published: August 2023

Abstract
The connections between the primary and secondary growth of trees allows better understanding of the dynamics of carbon sequestration in forest ecosystems. The relationship between primary and secondary growth of trees could change due to the diverging responses of meristems to climate warming. In this study, the bud phenology and radial growth dynamics of Qinghai spruce (Picea crassifolia) in arid and semi-arid areas of China in 2019 and 2020 were weekly monitored to analyze their response to different weather conditions and their links with carbon sink. Xylem anatomical traits (i.e. lumen radial diameter and cell wall thickness) were quantified along cell radial files after the end of xylem lignification to calculate the early-to-latewood transition date. Winter and early spring (January–March) were warmer in 2020 with a colder April compared with 2019. Precipitation in April–June was lower in 2020 than in 2019. In 2019, bud phenology occurred earlier, while the onset of xylem formation and the early-to-latewood transition date were delayed. The duration from the beginning of split bud and exposed shoot to the early-to-latewood transition date was positively correlated with the radial width of earlywood (accounting for ~80% of xylem width) and total xylem width. The longer duration of xylem cell division did not increase xylem cell production and radial width. Moreover, the duration from bud burst to the early-to-latewood transition date in 2020 was negatively linked with early phloem cell production as compared with 2019. Our findings suggest that warm conditions in winter and early spring promote the xylogenesis of Qinghai spruce, but might delay bud burst. However, the xylem width increments largely depend on the duration from bud burst to the start of latewood cell division rather than on the earlier xylogenesis and longer duration of xylem cell differentiation induced by warm conditions.
Evolutionary history, biogeography, and a new species of Sphoeroides (Tetraodontiformes: Tetraodontidae): how the major biogeographic barriers of the Atlantic Ocean shaped the evolution of a pufferfish genus
Authors: Araujo Gabriel S , Kurtz Yan R , Sazima Ivan , Carvalho Pedro Hollanda , Floeter Sergio R , Vilasboa Anderson , Rotundo Matheus M , Ferreira Carlos E L , Barreiros João Pedro , Pitassy Diane E , Carvalho-Filho Alfredo 
Published: August 2023

Abstract
Tetraodontidae is the most speciose family of Tetraodontiformes and is represented by fish popularly known as pufferfishes. They are characterized by modified jaws with four dental plates and the ability ﻿to inflate their bodies. Tetraodontids are distributed throughout the world and have a wide range of habitat use. One of its genera, Sphoeroides, shows a biogeographical pattern, with 19 of its 21 species restricted to coastal regions of the Americas. Although represented in large-scale phylogenies, the evolutionary history and biogeography of the genus have not been explored in detail. The present study aims to understand the historical and biogeographic processes that shaped the evolutionary history of Sphoeroides. Including samples from all biogeographic regions of its occurrence, we reconstruct a phylogenetic/biogeographic history hypothesis for the genus. Our results show that Sphoeroides is a paraphyletic group comprising Colomesus; indicate a central role of the biogeographic barriers of the Atlantic Ocean in the diversification of the genus; and identified a cryptic species in Brazilian waters, formally known as S. spengleri, described here through integrative taxonomy. We also propose nomenclatural changes given the position of Colomesus deeply nested within Sphoeroides.
Hiding in the mists: molecular phylogenetic position and description of a new genus and species of snake (Dipsadidae: Xenodontinae) from the remote cloud forest of the Lost World
Authors: Kok Philippe J R , Means D Bruce 
Published: August 2023

AbstractPantepui s.l. is a remote, biodiverse region of ~400 000 km2 containing at least five endemic reptile genera and a number of ancient vertebrate lineages. Here, we describe an additional endemic snake genus and species, Paikwaophis krukigen. nov., sp. nov. (Dipsadidae: Xenodontinae), recently collected in the Pantepui cloud forest that sits at the base of the steep cliffs of Roraima-tepui and Wei-Assipu-tepui (table mountains of the Eastern Tepui Chain) in Guyana, South America. Multilocus molecular data strongly support Paikwaophisgen. nov. to be most closely related to Xenopholis Peters, 1869, although both genera are strikingly different morphologically. Osteological and other phenotypic data suggest that Paikwaophis is semi-fossorial; its diet includes minute lizards. Paikwaophis is currently the only known Pantepui endemic snake genus. The immature female holotype is the only known specimen.
Morphologic Changes of the Intervertebral Disk During Growth
Authors: Moens Aaron J.B.W.D. , Magré Joëll , Kruyt Moyo C. , Castelein René M. , de Reuver Steven 
Published: August 2023

Study Design.
Cross-sectional.

Objective.
The aim of this study was to describe morphologic changes of the annulus fibrosus (AF) and nucleus pulposus (NP) in children during growth using magnetic resonance imaging.

Summary of Background Data.
Little is known of intervertebral disk (IVD) maturation as opposed to degeneration, such as changes in relative AF/NP proportions and orientation during growth. Studies suggest that IVD plays a role in the etiology of pediatric spinal deformities. Therefore, understanding the morphologic development of the AF and NP during growth is key.

Materials and Methods.
An existing database of children aged 0 to 18 that had magnetic resonance imaging for indications unrelated to the spine were analyzed. The AF/NP were segmented semiautomatically from T1 to L5. The parameters: mean IVD height, cross-sectional area, slenderness (height/width ratio), volume (ratio), and relative position of the centroid of the NP within the IVD in three directions (x, y, z) were extracted, and compared between age, sex, and spinal level.

Results.
IVD height increased modestly and predominantly in the low-thoracic and lumbar spine during the first 5 to 10 years of life. Cross-sectional area and thus volume increased steadily at all levels throughout growth. IVD slenderness decreased sharply in the first years of life and remains relatively stable throughout the remainder of growth. IVDs were smaller and more slender in females, especially in the mid-thoracic spine at early adolescence. In the upper-thoracic and mid-thoracic spine the NP comprises 10% to 12% of total IVD volume during growth, this percentage increases in the low-thoracic and lumbar spine towards 20% to 25%. In the anterior-posterior direction, the position of the nucleus increasingly shifts with age, possibly in line with the developing sagittal profile of the spine.

Conclusion.
This study describes the development of thoracic and lumbar IVDs during growth and may be used as a reference for future studies on the role of IVD in the etiology of disk-related disorders.
Early sodium bicarbonate infusion was associated with improved outcome in critically ill patients with acute moderate metabolic acidosis: a retrospective observational study
Authors: Huang Sai , Yang Bo , Peng Yaojun , Wang Libo , Wang Lili , Wang Jing , Zhou Xuan , Zhu Hanyu , Chen Li , Feng Cong 
Published: August 2023

Abstract

Background
Sodium bicarbonate (SB) infusion is widely administered for severe metabolic acidosis (MA). However, evidence supporting its effect on mortality in patients with acute moderate MA (MMA) has not yet been established. This study investigated the effect of early SB administration on mortality in critically ill patients with acute MMA and in other subgroups.

Methods
We retrospectively analyzed a large intensive care unit (ICU) database, Medical Information Mart for Intensive Care (MIMIC)-IV. Patients with acute MMA were identified using MIMIC-IV. Propensity score analysis (PSA) was performed to explain baseline differences in the probability of receiving SB. The marginal structural Cox model (MSCM) was developed to adjust for both baseline and time-varying confounding variables. The primary outcome was ICU mortality, and the secondary outcome was hospital mortality.

Results
In total, 1738 patients with acute MMA were identified; 484 were enrolled in the SB group and 1254 in the non-SB group. In the PSA, early SB infusion was not associated with reduced ICU mortality (hazard ratio [HR]: 0.88; 95% confidence interval [CI]: 0.67–1.14; P = 0.33) in the overall cohort. However, it was associated with improved ICU survival in patients with sepsis (HR: 0.69; 95% CI: 0.48–0.99; P < 0.05), sepsis shock (HR: 0.61; 95% CI: 0.40–0.93; P < 0.05), and sepsis and lactic acidosis (lactate >2.2 mmol/L; HR: 0.69; 95% CI: 0.48–0.99; P < 0.05). The results from MSCM were similar to those obtained for PSA.

Conclusion
Early SB infusion was associated with improved ICU survival outcomes in critically ill adult patients with sepsis, septic shock, and sepsis and lactic acidosis and acute MMA. Further large randomized controlled trials are required to confirm these results.
Combining Multiple Oncoplastic Techniques to Facilitate Extreme Oncoplastic Breast Conservation
Authors: Schwartz Jean-Claude D. 
Published: August 2023

Summary:
Centers of excellence strive for high rates of breast conservation surgery. Given the increased patient satisfaction, evidence for improved survival, decreased rates of complications, reduced costs, and fewer surgical procedures compared to mastectomy and reconstruction, this makes sense. As such, surgeons have devised approaches to offer breast conservation to patients with more extensive disease that would have been classically recommended to undergo mastectomy. These ambitious attempts at breast conservation are supported by recent studies that have established their oncological safety. “Extreme oncoplasty” refers to Wise-pattern volume displacement surgery where the breast is immediately reconstructed after a multifocal or multicentric breast cancer is excised. The authors that described this concept also described a Wise-pattern “split reduction” to allow for excision of the skin directly over the cancer, insuring a clear anterior margin. Although extreme oncoplasty has been broadly discussed and published on by many groups, there are few reports that provide insight into the surgical details necessary to successfully perform this surgery. Here, we combine three different oncoplastic techniques: the Wise-pattern split reduction, immediate nipple reconstruction, and autologous volume replacement to demonstrate our approach to extreme oncoplastic breast conservation in a challenging patient.
Hybrid Regenerative Therapy for Successful Reconstruction of an Infected Traumatized Diabetic Foot Wound
Authors: Saha Srinjoy 
Published: August 2023

Summary:
Diabetic foot ulcers are a significant complication of diabetes, affecting millions globally, and require appropriate antibiotics, surgical debridement, wound care, and metabolic optimization for management. This article presents an innovative hybrid regenerative therapy for reconstructing an infected, traumatized foot wound of a 62-year-old man with diabetes mellitus who presented with a week-old injury after a car accident. At presentation, he had a 14 × 10 cm dorsal foot wound with skin necrosis, pus discharge, and bony instability owing to partial fractures and joint dislocations. Antibiotics were administered to treat multidrug-resistant bacteria and followed by surgical debridement and the application of a portable Velnext negative pressure wound therapy device. Once the wound condition stabilized, hybrid regenerative therapy was performed weekly. Six milliliters platelet-rich plasma and 6 mL platelet-poor plasma were prepared from 27 mL of venous blood mixed with 3 mL sodium citrate and injected into the tendons, soft-tissues, and muscles. Next, the exposed bones and tendons were covered with platelet-rich fibrin and semi-occlusive membranes, and a Velnext negative pressure wound therapy device was applied over them. The wound improved progressively during the subsequent 6 weeks and was finally covered with a split-skin graft. The patient had a successful 18-month postoperative period until now with stable grafts, anatomical restoration, and excellent foot functionality. Thus, hybrid regenerative therapy, encompassing several prevalent methods for healing wounds, has excellent benefits for treating complex diabetic foot ulcers.