bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking autism spectrum disorders and parkinsonism: clinical and genetic association
Authors: Mai Aaron Shengting , Yau Chun En , Tseng Fan Shuen , Foo Qi Xuan Joel , Wang Dennis Qing , Tan Eng‐King 
Published: February 2023

AbstractBackgroundAutism spectrum disorders (ASD) comprise many complex and clinically distinct neurodevelopmental conditions, with increasing evidence linking them to parkinsonism.MethodsWe searched Medline and Embase from inception to 21 March 2022 and reviewed the bibliographies of relevant articles. Studies were screened and reviewed comprehensively by two independent authors.ResultsOf 863 references from our search, we included eight clinical studies, nine genetic studies, and five case reports. Regardless of age group, Parkinson's disease (PD) and parkinsonian syndromes were more frequently observed in patients with ASD, though the evidence for increased rates of parkinsonism is less clear for children and adolescents. Parkinsonian features and hypokinetic behavior were common in Rett syndrome, with prevalence estimates ranging from 40% to 80%. Frequently observed parkinsonian features include bradykinesia, rigidity, hypomimia, and gait freezing. PD gene PARK2 copy number variations appear more frequently in ASD cases than controls. Evidence suggests that RIT2 and CD157/BST1 are implicated in ASD and PD, while the evidence for other PD‐related genes (DRD2, GPCR37, the SLC gene family, and SMPD1) is less clear. Rare mutations, such as ATP13A2, CLN3, and WDR45, could result in autistic behavior and concomitant parkinsonism.ConclusionThe prevalence of parkinsonism in ASD is substantially greater than in the general population or matched controls. Various PD‐associated gene loci, especially PARK2, could confer susceptibility to ASD as well. Important future directions include conducting prospective cohort studies to understand how parkinsonian symptoms may progress, genetic studies to reveal relevant gene loci, and pathophysiologic studies to identify potential therapeutic targets.
Associations of Postdischarge Follow‐Up With Acute Care and Mortality in Lupus: A Medicare Cohort Study
Authors: Schletzbaum Maria , Sweet Nadia , Astor Brad , Yu Ang , Powell W. Ryan , Gilmore‐Bykovskyi Andrea , Kaiksow Farah , Sheehy Ann , Kind Amy J. , Bartels Christie M. 
Published: February 2023

ObjectivePatients with systemic lupus erythematosus experience the sixth highest rate of 30‐day readmissions among chronic diseases. Timely postdischarge follow‐up is a marker of ambulatory care quality that can reduce readmissions in other chronic conditions. Our objective was to test the hypotheses that 1) beneficiaries from populations experiencing health disparities, including patients from disadvantaged neighborhoods, will have lower odds of completed follow‐up, and that 2) follow‐up will predict longer time without acute care use (readmission, observation stay, or emergency department visit) or mortality.MethodsThis observational cohort study included hospitalizations in January–November 2014 from a 20% random sample of Medicare adults. Included hospitalizations had a lupus code, discharge to home without hospice, and continuous Medicare A/B coverage for 1 year before and 1 month after hospitalization. Timely follow‐up included visits with primary care or rheumatology within 30 days. Thirty‐day survival outcomes were acute care use and mortality adjusted for sociodemographic information and comorbidities.ResultsOver one‐third (35%) of lupus hospitalizations lacked 30‐day follow‐up. Younger age, living in disadvantaged neighborhoods, and rurality were associated with lower odds of follow‐up. Follow‐up was not associated with subsequent acute care or mortality in beneficiaries age <65 years. In contrast, follow‐up was associated with a 27% higher hazard for acute care use (adjusted hazard ratio [HR] 1.27 [95% confidence interval (95% CI) 1.09–1.47]) and 65% lower mortality (adjusted HR 0.35 [95% CI 0.19–0.67]) among beneficiaries age ≥65 years.ConclusionOne‐third of lupus hospitalizations lacked follow‐up, with significant disparities in rural and disadvantaged neighborhoods. Follow‐up was associated with increased acute care, but 65% lower mortality in older systemic lupus erythematosus patients. Further development of lupus‐specific postdischarge strategies is needed.image
Recruitment and Retention Strategies for Underrepresented Populations and Adults With Arthritis in Behavioral Interventions: A Scoping Review
Authors: Pellegrini Christine A. , Wilcox Sara , DeVivo Katherine E. , Jamieson Scott 
Published: February 2023

ObjectiveTo identify strategies used to recruit and retain underrepresented populations and populations with arthritis or fibromyalgia (FM) into behavioral programs targeting exercise, physical activity, or chronic disease self management.MethodsFive bibliographic databases were searched for articles published between January 2000 and May 2022. The search focused on strategies and best practices for recruiting and retaining underrepresented populations or populations with arthritis or FM into disease self‐management or physical activity/exercise programs. Abstracts and full‐text articles were screened for inclusion by 2 independent reviewers, and 2 reviewers extracted data from included articles.ResultsOf the 2,800 articles, a total of 43 publications (31 interventions, 8 reviews, 4 qualitative/descriptive studies) met criteria and were included. The majority of studies focused on physical activity/exercise (n = 36) and targeted African American (n = 17), Hispanic (n = 9), or arthritis populations (n = 7). Recruitment strategies that were frequently used included having race‐ or community‐matched team members, flyers and information sessions in areas frequented by the population, targeted emails/mailings, and word of mouth referrals. Retention strategies used included having race‐ or community‐matched team members, incentives, being flexible, and facilitating attendance. Most studies used multiple recruitment and retention strategies.ConclusionThis scoping review highlights the importance of a multifaceted recruitment and retention plan for underrepresented populations and populations with arthritis or FM in behavioral intervention programs targeting exercise, physical activity, or chronic disease self management. Additional research is needed to better understand the individual effects of different strategies and the costs associated with the various recruitment/retention methods in underrepresented populations and populations with arthritis.
Myeloid Cells As a Promising Target for Brain–Bone Degenerative Diseases from a Metabolic Point of View
Authors: Pang Yidan , Zhu Siyuan , Xu Jun , Su Cuimin , Wu Bo , Zhang Changqing , Gao Junjie 
Published: February 2023

AbstractBrain and bone degenerative diseases such as Alzheimer's disease and osteoporosis are common in the aging population and lack efficient pharmacotherapies. Myeloid cells are a diverse group of mononuclear cells that plays important roles in development, immune defense, and tissue homeostasis. Aging drastically alters the expansion and function of myeloid cells, which might be a common pathogenesis of the brain–bone degenerative diseases. From this perspective, the role of myeloid cells in brain–bone degenerative diseases is discussed, with a particular focus on metabolic alterations in myeloid cells. Furthermore, targeting myeloid cells through metabolic regulation via drugs such as metformin and melatonin is proposed as a potential therapy for the clinical treatment of brain–bone diseases.
Two Distinct Carbocyclizations of (2‐Formylphenyl)prop‐2‐yn‐1‐yl acetates to Form Substituted 1H‐indene Derivatives and 4‐Acetoxy‐3‐hydroxy‐2‐naphthoates. Cooperative Catalysis using Au(I)/H2O Dual Catalysts
Authors: Suresh Kshirsagar Akshay , Dixit Surya , Liu Rai‐Shung 
Published: February 2023

AbstractGold‐catalyzed cyclizations of (2‐formylphenyl)prop‐2‐yn‐1‐yl acetates afford two distinct cyclization products. In the case of substrates bearing a alkyl or arylalkynyl group, 2‐carbonyl‐1H‐indene derivatives were obtained whereas substrates bearing an electron‐withdrawing alkynoate or alkynone group, distinct 4‐acetoxy‐3‐hydroxy‐2‐naphthoates were produced efficiently. Our mechanistic analysis indicates that H2O is not only a nucleophile but also a catalyst for both carbocyclizations.magnified image
Flexible Hybrid Electronics via Near‐Infrared Radiation‐Assisted Soldering of Surface Mount Devices on Screen Printed Circuits
Authors: Kasi Venkat , Zareei Amin , Gopalakrishnan Sarath , Alcaraz Alejandro M. , Joshi Shantanu , Arfaei Babak , Rahimi Rahim 
Published: February 2023

AbstractThe development of flexible hybrid electronics (FHEs) with high‐throughput integration of electrical components onto digitally printed circuits has a wide range of applications, such as asset tracking, wearable electronics, and structural health monitoring. However, one of the major challenges with FHEs is the process of soldering the electrical components onto a printed circuit while having minimal thermal damage to the printed traces and their temperature‐sensitive polymeric substrates. Here, the possibility of utilizing near‐infrared (NIR) technology as a nondestructive photonic approach for rapid soldering and mounting electrical components onto printed circuits while keeping the polymer substrate at a relatively low temperature during the soldering process is investigated. Results of this systematic study show that FHEs prepared with the optimized NIR processing conditions produce the desired reflow of solder with effective electrical connection and metallic bonding of electrical components onto the conductive traces with excellent mechanical stability (no failure even after 1000 cycles of bending). Furthermore, using this technique and as a proof of concept, the fabrication of a wearable FHE device that provides a remote assessment of the wound exudate absorption in dressings and notifies caregivers of the appropriate time to change the dressing is demonstrated.
Perovskite‐based electrocatalyst discovery and design using word embeddings from retrained SciBERT language model
Authors: Muthukkumaran Arun , Raghunathan Shrayas , Ravichandran Arjun , Rengaswamy Raghunathan 
Published: February 2023

AbstractWith the ever‐increasing volume of scientific literature, there is a strong need to develop methods that allow rigorous information identification. In this contribution, a state‐of‐the‐art natural language processing (NLP) model was used to select perovskite materials for electrocatalytic applications from literature. This was accomplished by obtaining word embeddings for perovskite materials from the NLP model and subsequently designing downstream tasks to discover perovskite‐based electrocatalyst materials. However, embeddings could be obtained only for materials available in the literature. Consequently, a novel methodology was devised to generate embeddings for newly designed materials. Results from the analysis showed that the computed embeddings could be used to rank materials for their suitability for electrocatalytic applications. Further, the word embeddings were also employed as features in predicting the electrocatalytic activity of perovskite‐based electrocatalysts. The analysis demonstrated that the fidelity of regression models increased when the embeddings were used as features.
ABNO‐Catalyzed Aerobic Oxidation of Thiols to Disulfides under Atmospheric Pressure
Authors: Zhang Zhiguang , Lan Xiaojie , Zhang Xiaomin , Liu Yanmei , Gao Jinxin , Zhang Bingzhu , Wu Haixia 
Published: February 2023

AbstractWe report herein a practical protocol for the synthesis of symmetrical disulfides under atmospheric pressure, utilizing 1 mol% ABNO (9‐Azabicyclo[3.3.1]nonane N‐oxyl) as an efficient catalyst and O2 as terminal oxidant. Thiophenols and aliphatic thiols could be oxidized smoothly to give disulfides in 70%–90% yields. This method has advantages such as high atom‐economy, commercially available catalyst, broad substrate scope and mild reaction conditions, providing researchers a simple and attractive way to synthesize disulfides.
The deep trabecular structure of first metacarpals in extant hominids
Authors: Dunmore Christopher J. , Bachmann Sebastian , Synek Alexander , Pahr Dieter H. , Skinner Matthew M. , Kivell Tracy L. 
Published: February 2023

AbstractObjectivesRecent studies have associated subarticular trabecular bone distribution in the extant hominid first metacarpal (Mc1) with observed thumb use, to infer fossil hominin thumb use. Here, we analyze the entire Mc1 to test for interspecific differences in: (1) the absolute volume of trabecular volume fraction, (2) the distribution of the deeper trabecular network, and (3) the distribution of trabeculae in the medullary cavity, especially beneath the Mc1 disto‐radial flange.Materials and MethodsTrabecular bone was imaged using micro‐computed tomography in a sample of Homo sapiens (n = 11), Pan paniscus (n = 10), Pan troglodytes (n = 11), Gorilla gorilla (n = 10) and Pongo sp., (n = 7). Using Canonical Holistic Morphometric Analysis (cHMA), we tested for interspecific differences in the trabecular bone volume fraction (BV/TV) and its relative distribution (rBV/TV) throughout the Mc1, including within the head, medullary cavity, and base.ResultsP. paniscus had the highest, and H. sapiens the lowest, BV/TV relative to other species. rBV/TV distribution statistically distinguished the radial concentrations and lack of medullary trabecular bone in the H. sapiens Mc1 from all other hominids. H. sapiens and, to a lesser extent, G. gorilla also had a significantly higher trabecular volume beneath the disto‐radial flange relative to other hominids.DiscussionThese results are consistent with differences in observed thumb use in these species and may also reflect systemic differences in bone volume fraction. The trabecular bone extension into the medullary cavity and concentrations beneath the disto‐radial flange may represent crucial biomechanical signals that will aid in the inference of fossil hominin thumb use.
CO2‐Fueled Transient Breathing Nanogels that Couple Nonequilibrium Catalytic Polymerization
Authors: Wang Yixin , Yan Qiang 
Published: February 2023

AbstractHere we present a “breathing” nanogel that is fueled by CO2 gas to perform temporally programmable catalytic polymerization. The nanogel is composed of common frustrated Lewis pair polymers (FLPs). Dynamic CO2‐FLP gas‐bridging bonds endow the nanogel with a transient volume contraction, and the resulting proximal effect of bound FLPs unlocks its catalytic capacity toward CO2. Reverse gas depletion via a CO2‐participated polymerization can induce a reverse nanogel expansion, which shuts down the catalytic activity. Control of external factors (fuel level, temperature or additives) can regulate the breathing period, amplitude and lifecycle, so as to affect the catalytic polymerization. Moreover, editing the nanogel breathing procedure can sequentially evoke the copolymerization of CO2 with different epoxide monomers preloaded therein, which allows to obtain block‐tunable copolycarbonates that are unachievable by other methods. This synthetic dissipative system would be function as a prototype of gas‐driven nanosynthesizer.
Boosting Electroreduction Kinetics of Nitrogen to Ammonia via Atomically Dispersed Sn Protuberance
Authors: Zhang Lijuan , Zhou Hanfeng , Yang Xiaoju , Zhang Shengbo , Zhang Haimin , Yang Xuan , Su Xintai , Zhang Jiangwei , Lin Zhang 
Published: February 2023

AbstractAtomically dispersed metal catalysts show potential advantages in N2 reduction reaction (NRR) due to their excellent activity and efficient metal utilization. Unfortunately, the reported catalysts usually exhibit unsatisfactory NRR activity due to their poor N2 adsorption and activation. Herein, we report a novel Sn atomically dispersed protuberance (ADP) by coordination with substrate C and O to induce positive charge accumulation on Sn site for improving its N2 adsorption, activation and NRR performance. The extended X‐ray absorption fine structure (EXAFS) spectra confirmed the local coordination structure of the Sn ADPs. NRR activity was significantly promoted via Sn ADPs, exhibiting a remarkable NH3 yield (RNH3) of 28.3 μg h−1 mgcat−1 (7447 μg h−1 mgSn−1) at −0.3 V. Furthermore, the enhanced N2Hx intermediates was verified by in situ experiments, yielding consistent results with DFT calculation. This work opens a new avenue to regulate the activity and selectivity of N2 fixation.
Electrochemical Interfacial Polymerization toward Ultrathin COF Membranes for Brine Desalination
Authors: Wang Meidi , Wang Yutong , Zhao Junyi , Zou Jiyu , Liang Xu , Zhu Ziting , Zhu Jiashi , Wang Hongjian , Wang Yuhan , Pan Fusheng , Jiang Zhongyi 
Published: February 2023

AbstractUltrathin covalent organic framework (COF) membranes are urgently demanded in molecular/ionic separations. Herein, we reported an electrochemical interfacial polymerization strategy to fabricate ultrathin COF membranes with thickness of 85 nm, by actively manipulate self‐healing effect and self‐inhibiting effect. The resulting COF membrane exhibited superior performance in brine desalination with the permeation flux of 92 kg m−2 h−1 and the rejection of 99.96 %. Our electrochemical interfacial polymerization strategy enriches the fabrication approach of COF membranes and facilitates the rational design of ultrathin membranes.
Chemically Recyclable Polyethylene‐like Sulfur‐Containing Plastics from Sustainable Feedstocks
Authors: Xia Yanni , Yue Xinchen , Sun Yue , Zhang Chengjian , Zhang Xinghong 
Published: February 2023

AbstractThe green revolution in plastics should be accelerated due to growing sustainability concerns. Here, we develop a series of chemically recyclable polymers from the first reported cascade polymerization of H2O, COS, and diacrylates. In addition to abundant feedstocks, the method is efficient and air‐tolerant, uses common organic bases as catalysts, and yields polymers with high molecular weights under mild conditions. Such polymers, structurally like polyethylene with low‐density in‐chain polar groups, manifest impressive toughness and ductility comparable to high‐density polyethylene. The in‐chain ester group acts as a breaking point, enabling these polymers to undergo chemical recycling through two loops. The structures and properties of these polymers also have an immeasurably expanded range owing to the versatility of our method. The readily available raw materials, facile synthesis, and high performance make these polymers promising prospects as sustainable materials in practice.
The Rigid Core and Flexible Surface of Amyloid Fibrils Probed by Magic‐Angle‐Spinning NMR Spectroscopy of Aromatic Residues
Authors: Becker Lea Marie , Berbon Mélanie , Vallet Alicia , Grelard Axelle , Morvan Estelle , Bardiaux Benjamin , Lichtenecker Roman , Ernst Matthias , Loquet Antoine , Schanda Paul 
Published: February 2023

AbstractAromatic side chains are important reporters of the plasticity of proteins, and often form important contacts in protein–protein interactions. We studied aromatic residues in the two structurally homologous cross‐β amyloid fibrils HET‐s, and HELLF by employing a specific isotope‐labeling approach and magic‐angle‐spinning NMR. The dynamic behavior of the aromatic residues Phe and Tyr indicates that the hydrophobic amyloid core is rigid, without any sign of “breathing motions” over hundreds of milliseconds at least. Aromatic residues exposed at the fibril surface have a rigid ring axis but undergo ring flips on a variety of time scales from nanoseconds to microseconds. Our approach provides direct insight into hydrophobic‐core motions, enabling a better evaluation of the conformational heterogeneity generated from an NMR structural ensemble of such amyloid cross‐β architecture.
Effect of color on scratch and mar visibility of polymers
Authors: De Noni Lorenzo , Marjuban Shaik Merkatur Hakim , Andena Luca , Noh Kwanghae , Li Yuntao , Vollenberg Peter , Sue Hung‐Jue 
Published: February 2023

AbstractPolymer scratch mechanics has been widely studied. However, the physics behind scratch visibility is still not well understood. Scratch deformation mechanisms certainly affect visibility but also other material properties, such as roughness, color, or gloss. This work relates to methods to quantitatively evaluate the effect of sample color on polymer scratch and mar induced visibility, aiming at linking scratch behavior with the underlying physics. A custom‐built black box was utilized for the analysis of samples possessing different colors and surface finishing. Automatic image analysis was performed through a commercial software to quantify the onset of visibility in terms of a critical load above which the scratch becomes visible. Trained surveyors visually quantified said critical load. White color was shown to delay the onset of visibility by reducing the contrast between the damaged and undamaged area. For instance, the critical load for the onset of visibility for a white polycarbonate copolymer was nearly twice the value reported for its black variant. Consistent results were obtained for all tested samples. Similar findings were reported for the mar phenomenon, highlighting how white color can also mask a different type of damage. The usefulness of the present work and some future perspectives are discussed.
Effect of Light and Electrostatic Gate at Oxide Interface LaFeO3–SrTiO3 at Room Temperature
Authors: Kaur Ripudaman , Kumari Anamika , Satapathy Bibek Ranjan , Gupta Anshu , Kumar Sanjeev , Chakraverty Suvankar 
Published: February 2023

AbstractElectrostatic gating and light illumination are two widely used stimuli for semiconductor devices. Two‐dimensional electron gas (2DEG) at oxide heterostructures has shown potential in optoelectronics due to its high optical response and gate tuning property. The appearance of high photoconductivity and persistent photoconductivity at the oxide heterostructure of two insulators LaFeO3 and SrTiO3 is shown here. The photoconductivity has been further tuned using positive and negative back gating. A large change in conductivity has been achieved under the simultaneous application of light and electrostatic gating. A few measurement protocols that manifest possible applications of this interface as memory and switching devices are implemented.
Synthesis and biological evaluation of benzamide‐chalcone hybrids as potential c‐Met kinase and COX‐2 inhibitors
Authors: Bhojwani Heena , Begwani Khushboo , Bhor Vikrant , Bedi Parul , Balasinor Nafisa , Raut Sanketa , Joshi Urmila 
Published: February 2023

Abstractc‐Met kinase and cyclooxygenase 2 (COX‐2) enzymes are two significant targets in tumor progression. Chalcone and benzamide moieties were combined using molecular hybridization to assess their potential as c‐Met kinase and COX‐2 inhibitors. 4‐Methylbenzamide and 4‐chlorobenzamide chalcone analogs were synthesized, characterized, and evaluated for antiproliferative activity on Michigan Cancer Foundation‐7 (MCF‐7), HT‐29, MDA‐MB‐231, COLO‐205, and A549 cell lines by sulforhodamine‐B stain (SRB) assay. Following the SRB assay, compounds were evaluated for their c‐Met kinase and COX‐2 inhibitory potential. All compounds inhibited COX‐2 with half‐maximal inhibitory concentration (IC50) <10 µM. Compounds 7h, 7i, 7j, 8f, and 8j inhibited c‐Met with IC50 <10 µM. Compound 7h was evaluated for its long‐term antiproliferative and anti‐migratory effects by colony formation and wound healing assay. It exerted these effects in a concentration‐dependent manner. Compounds 7j and 8j were further evaluated for in vitro antiangiogenic effects. Compound 7j exhibited moderate antiangiogenic effect while compound 8j exhibited strong effect. Compounds 7h, 7i, 7j, 8f, and 8j were evaluated for the serum protein binding, using the in vitro bovine serum albumin binding assay. The results indicated that the tested compounds bind to bovine serum albumin (BSA) and can be further explored by other studies.