bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seizure control in women with epilepsy undergoing assisted reproductive technology
Authors: Abdulrazaq Aisha A. , Ainsworth Alessandra J. , Britton Jeffrey W. , Shenoy Chandra C. , Babayev Samir N. , Cascino Gregory D. , Smith Kelsey M. 
Published: August 2023

AbstractThe objective of this study was to determine seizure control in women with epilepsy (WWE) undergoing assisted reproductive technology (ART). Through retrospective chart review, WWE undergoing ART were identified. Demographics and details regarding epilepsy type, seizure control, and ART procedures were extracted. Seizure frequency prior to and during ART were compared. We identified 12 WWE, who underwent 29 embryo transfers, resulting in 16 pregnancies and 10 live births. Nine women were seizure‐free at least 2 years before fertility treatment, including three with resolved epilepsy. Seven were on antiseizure medications throughout fertility treatment and pregnancy, with only one on polytherapy. Eleven (all with controlled epilepsy or epilepsy in remission) remained seizure‐free throughout fertility treatment. One woman with drug‐resistant epilepsy continued to have seizures throughout fertility treatment and pregnancy without an exacerbation of seizure frequency. There was no increased seizure frequency associated with fertility treatment and subsequent pregnancy in this small series of WWE. Although this study was statistically underpowered, our results provide some preliminary evidence that ART might not pose a threat to seizure control, but larger, confirmatory studies are necessary.
First unprovoked seizures among soldiers recruited to the Israeli Defense Forces during 10 consecutive years: A population‐based study
Authors: Tsur Adili , Spierer Ronen , Cohen Renana , Blatch Dana , Eyal Sara , Honig Asaf , Ekstein Dana 
Published: August 2023

AbstractObjectiveThe management of patients after a first unprovoked seizure (FUS) can benefit from stratification of the average 50% risk for further seizures. We characterized subjects with FUSs, out of a large generally healthy homogenous population of soldiers recruited by law to the Israeli Defense Forces, to investigate the role of the type of service, as a trigger burden surrogate, in the risk for additional seizures.MethodsSoldiers recruited between 2005 and 2014, who experienced an FUS during their service, were identified from military records. Subjects with a history of epilepsy or lack of documentation of FUS characteristics were excluded from the study. Data on demographics and military service and medical details were extracted for the eligible soldiers.ResultsOf 816 252 newly recruited soldiers, representing 2 138 000 person‐years, 346 had an FUS, indicating an incidence rate of 16.2 per 100 000 person‐years. The FUS incidence rate was higher in combat versus noncombat male and female soldiers (p < .0001). Most subjects (75.7%) were prescribed antiseizure medications (ASMs), and 29.2% had additional seizures after the FUS. Service in combat units, abnormal magnetic resonance imaging, and being prescribed ASMs were correlated with a lower risk of having multiple seizures (95% confidence interval [CI] = .48–.97, .09–.86, .15–.28, respectively). On multivariate analysis, service in combat units (odds ratio [OR] = .48 for seizure recurrence, 95% CI = .26–.88) and taking medications (OR = .46, 95% CI = .24–.9) independently predicted not having additional seizures.SignificanceFUS incidence rate was higher in combat soldiers, but they had a twofold lower risk of additional seizures than noncombat soldiers, emphasizing the value of strenuous triggers as negative predictors for developing epilepsy. This suggests a shift in the perception of epilepsy from a “yes or no” condition to a continuous trend of predisposition to seizures, warranting changes in the ways etiologies of epilepsy are weighted and treatments are delivered.
Prevalence of ictal injuries in functional (psychogenic nonepileptic) seizures: A systematic review and meta‐analysis
Authors: Moreira Adriana Boschi , Knochenhauer André Enoch , Froehner Giullia Victória , Schwarzbold Marcelo Liborio , Asadi‐Pooya Ali Akbar , Demarchi Izabel Galhardo , Brigo Francesco , Lin Katia 
Published: August 2023

AbstractObjectiveIctal injuries have long been considered typical signs of epileptic seizures. However, studies have shown that patients with functional seizures (FS)—also named psychogenic nonepileptic seizures—can also present these signs, misleading physicians and delaying a correct diagnosis. This systematic review aimed to assess the prevalence of injuries from FS.MethodsA literature search was performed in PubMed, Embase, LILACS (Latin American and Caribbean Health Sciences Literature), Scopus, Web of Science, PsycINFO, Google Scholar, OpenGrey, and ProQuest. Observational studies were included. The risk of bias was assessed using the Joanna Briggs Institute (JBI) checklist for studies reporting prevalence data. RStudio was used for meta‐analyses. Cumulative evidence was evaluated according to Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) criteria.ResultsFrom the 2607 identified records, 41 studies were included in the qualitative synthesis, and 28 were included in meta‐analyses. A meta‐analysis of 13 studies, including 1673 individuals, resulted in an overall lifetime prevalence of injuries due to FS per person of 25% (95% confidence interval [CI] = 19%–32%, I2 = 88%). Considering a limited period (video‐electroencephalographic [VEEG] monitoring days), a meta‐analysis of 13 studies, including 848 individuals, resulted in an injury prevalence due to FS per person of .7% (95% CI = 0%–3%, I2 = 73%). Also, a meta‐analysis of eight studies, including 1000 individuals, resulted in a prevalence of injuries per FS of .1% (95% CI = 0%–.98%, I2 = 49%). The certainty in cumulative evidence assessed by GRADE was rated “very low” for lifetime prevalence of injuries per person, “low” for prevalence per person during VEEG monitoring, and “moderate” for prevalence per number of FS.SignificanceOverall pooled lifetime prevalence of injuries due to FS per person was 25%. In comparison, the prevalence of injuries per person during VEEG monitoring and per functional seizure was .7% and .1%, respectively. [Correction added on 07 October 2023, after first online publication: In the preceding sentence, ‘consecutively’ was corrected to ‘respectively’.] The evidence of the occurrence of injuries due to FS breaks the paradigm that epileptic seizures can cause injuries but FS cannot.
Acute symptomatic status epilepticus: Splitting or lumping? A proposal of classification based on real‐world data
Authors: Lattanzi Simona , Giovannini Giada , Brigo Francesco , Orlandi Niccolò , Trinka Eugen , Meletti Stefano 
Published: August 2023

AbstractThis study aimed to group acute symptomatic etiologies of consecutive episodes of status epilepticus (SE) into different subcategories and explore their associations with clinical outcome. Etiologies were first categorized as “acute,” “remote,” “progressive,” “SE in defined electroclinical syndromes,” and “unknown.” Four subcategories of acute etiologies were then defined: (1) withdrawal, low levels, or inappropriate prescription of antiseizure medications, or sleep deprivation in patients with pre‐existing epilepsy; (2) acute insults to central nervous system (CNS; “acute‐primary CNS”); (3) CNS pathology secondary to metabolic disturbances, systemic infection, or fever (“acute‐secondary CNS”); and (4) drug/alcohol intoxication or withdrawal. Poor outcome at discharge, defined as worsening of clinical conditions (modified Rankin Scale [mRS] at discharge higher than mRS at baseline), was reported in 55.6% of cases. The etiological categories of acute‐primary CNS (odds ratio [OR] = 3.61, 95% confidence interval [CI] = 2.11–6.18), acute‐secondary CNS (OR = 1.80, 95% CI = 1.11–2.91), and progressive SE (OR = 2.65, 95% CI = 1.57–4.47), age (OR = 1.05, 95% CI = 1.04–1.06), nonconvulsive semiology with coma (OR = 3.06, 95% CI = 1.52–6.17), and refractoriness (OR = 4.31, 95% CI = 2.39–7.77) and superrefractoriness to treatment (OR = 8.24, 95% CI = 3.51–19.36) increased the odds of poor outcome. Heterogeneity exists within the spectrum of acute symptomatic causes of SE, and distinct etiological subcategories may inform about the clinical outcome.
Influences of vitiligo‐associated characteristics on the occurrence of diabetes mellitus: Interactive analysis of a cross‐sectional study
Authors: Li Baizhang , Zhu Guannan , Kang Pan , Chen Jianru , He Kaiqiao , Wang Xinju , Gao Tianwen , Li Chunying , Li Shuli 
Published: August 2023

AbstractThe risk of diabetes mellitus (DM) in vitiligo patients is higher than that in non‐vitiligo population. Our goal was to explore the influencing factors for DM in vitiligo patients. A matched‐pair design of 107 cases with DM and 428 controls without DM was conducted among vitiligo patients in Xijing hospital from January 2010 to October 2021. The baseline characteristics of patients were analysed based on standard descriptive statistics. The vitiligo‐associated characteristics were analysed by logistic regression to identify influencing factors of DM. Interaction analysis was performed to explore the additive interactions between vitiligo‐associated characteristics and baseline characteristics. After adjustment for the baseline characteristics, the severity of vitiligo [odds ratio (OR) = 2.47, 95% confidence interval (CI): 1.47–4.14] and onset age of vitiligo (OR = 0.98, 95% CI: 0.97–0.99) had a significant correlation with occurrence of DM. The severity of vitiligo had additive interaction with family history of diabetes [relative excess risk due to interaction (RERI) = 132.51 (95% CI: 5.51–1100.20), attributable proportion (AP) = 0.91 (95% CI: 0.17–0.95), synergy index (S) = 11.53 (95% CI: 1.32–100.5)] and with smoking history [RERI = 6.54 (95% CI: 0.67–19.83), AP = 0.64 (95% CI: 0.04–0.80), S = 3.48 (95% CI: 1.17–10.36)]. Earlier onset age of vitiligo and greater BSA involvement might be two independent risk factors for DM in vitiligo patients. Interaction assessment identified the severity of vitiligo as additive interaction factors with diabetes family history and with smoking history for the DM occurrence.
Neutrophil extracellular traps formation in the lesional skin of various types of pyoderma gangrenosum
Authors: Ishikawa Masato , Yamamoto Toshiyuki 
Published: August 2023

AbstractPyoderma gangrenosum (PG) is a chronic neutrophilic disorder characterized by recurrent painful ulcers. Aseptic inflammation by neutrophils plays an essential role, and neutrophil extracellular traps (NETs) formation can contribute to the pathogenesis of PG. Seventy‐five patients were diagnosed as having PG in our department, among which 58 ulcerative, 4 bullous, 3 pustular and 10 vegetative type. We examined the 20 skin biopsy specimens (11 ulcerative, 3 bullous, 2 pustular and 4 vegetative type), and local NETs formation in various types of PG was compared among each type. The biopsied specimens were double labelled for myeloperoxidase, citrullinated histone H3. Immunofluorescent images indicated that the histopathologic location and depth of NETs formation in PG varied by the clinical subtypes. In ulcerative PG, NETs formation was observed in the upper to deep dermis. In bullous PG, NETs formation was mainly observed in the epidermis. Pustular type showed NETs formation in the epidermis near the pustules, and in vegetative type, showed NETs formation mainly in the upper dermis. These results indicate that NETting neutrophils play an important role in the pathogenesis of various forms of PG, although the location and depth of NETs formation in the skin lesion of PG differ depending on each type. Further studies are necessary to examine what factors identify different clinical features of PG.
Multi‐output regression for imbalanced data stream
Authors: Peng Tao , Sellami Sana , Boucelma Omar , Chbeir Richard 
Published: August 2023

AbstractIn this article, we describe an imbalanced regression method for making predictions over imbalanced data streams. We present MORSTS (Multiple Output Regression for Streaming Time Series), an online ensemble regressors devoted to non‐stationary and imbalanced data streams. MORSTS relies on several multiple output regressor submodels, adopts a cost sensitive weighting technique for dealing with imbalanced datasets, and handles overfitting by means of the K‐fold cross validation. For assessment purposes, experiments have been conducted on known real datasets and compared with known base regression techniques.
Acceptability of a shared cancer follow‐up model of care between general practitioners and radiation oncologists: A qualitative evaluation
Authors: Sandell Tiffany , Schütze Heike , Miller Andrew 
Published: August 2023

AbstractIntroductionFacilitators to implement shared cancer follow‐up care into clinical practice include mechanisms to allow the oncologist to continue overseeing the care of their patient, two‐way information sharing and clear follow‐up protocols for general practitioners (GPs). This paper aimed to evaluate patients, GPs and radiation oncologists (ROs) acceptance of a shared care intervention.MethodsSemi‐structured interviews were conducted pre‐ and post intervention with patients that were 3 years post radiotherapy treatment for breast, colorectal or prostate cancer, their RO, and their GP. Inductive and deductive thematical analysis was employed.ResultsThirty‐two participants were interviewed (19 patients, 9 GPs, and 4 ROs). Pre intervention, there was support for GPs to play a greater role in cancer follow‐up care, however, patients were concerned about the GPs cancer‐specific skills. Patients, GPs and ROs were concerned about increasing the GPs workload. Post intervention, participants were satisfied that the GPs had specific skills and that the impact on GP workload was comparable to writing a referral. However, GPs expressed concern about remuneration. GPs and ROs felt the model provided patient choice and were suitable for low‐risk, stable patients around 2–3 years post treatment. Patients emphasised that they trusted their RO to advise them on the most appropriate follow‐up model suited to their individual situation. The overall acceptance of shared care depended on successful health technology to connect the GP and RO. There were no differences in patient acceptance between rural, regional, and cancer types. ROs presented differences in acceptance for the different cancer types, with breast cancer strongly supported.ConclusionPatients, GPs and ROs felt this shared cancer follow‐up model of care was acceptable, but only if the RO remained directly involved and the health technology worked. There is a need to review funding and advocate for health technology advances to support integration.Patient or Public ContributionPatients treated with curative radiotherapy for breast, colorectal and prostate cancer, their RO and their GPs were actively involved in this study by giving their consent to be interviewed.
Genetic diversity and gene flow of the soil arthropod (Scolopendra mutilans) in urban landscapes: The roles of rivers, mountains and fragmentation
Authors: Xu Tangjun , Zhou Kexin , Ye Wentao , Huang Yalin , Zhang Yufeng , Zhu Sheng , Ruan Honghua , Liu Hongyi 
Published: August 2023

Abstract
Soil invertebrates are a major element of soil biodiversity, which play critical roles in soil ecosystems. However, the impacts of urban landscapes on the genetic diversity and gene flows of soil arthropods remain unclear.
Here, we studied the genetic diversity and gene flow of Scolopendra mutilans in an urban area using mitochondrial Cytb genes and eight novel microsatellite loci.
A total of 22 haplotypes and 24 variation sites were identified based on 556 bp Cytb sequences from 84 individuals of five populations in Nanjing, Jiangsu Province, China. There were 5.63–8.00 alleles in the average of eight microsatellites found in the S. mutilans arthropod populations, which showed high genetic diversity in urban landscapes. There was no correlation between the natural habitat size and genetic diversity of S. mutilans. The global Fst value based on microsatellites was 0.115, which suggested a medium genetic differentiation and population isolation.
The genetic structure of S. mutilans might be affected by urbanisation, as urban patches might hinder gene flow between populations. Ecological corridors preserved in cities might serve as pathways for population migration, which increases gene flow. The gene flows of S. mutilans might not be hindered by natural barriers within cities, as there were strong relationships between populations separated by rivers.
These results may contribute to the conservation of S. mutilans diversity and elucidate its adaptation to urbanisation.
In vitro assessment of antimicrobial potential of low molecular weight chitosan and its ability to mechanically reinforce and control endogenous proteolytic activity of dentine
Authors: Pascale Christina , Geaman Jay , Mendoza Christine , Gao Feng , Kaminski Amber , Cuevas‐Nunez Maria , Darvishan Behnam , Mitchell John C. , Carrilho Marcela R. , Sigar Ira 
Published: August 2023

AbstractAimsChitosan‐based biomaterials exhibit several properties of biological interest for endodontic treatment. Herein, a low molecular weight chitosan (CH) solution was tested for its antimicrobial activity against Enterococcus faecalis (E. faecalis) and effects on dentine structure.MethodologyThe root canal of 27 extracted uniradicular teeth were biomechanically prepared, inoculated with a suspension of E. faecalis and randomly assigned to be irrigated with either 5.25% sodium hypochlorite (NaClO), 0.2% CH or sterile ultrapure water (W). Bacteriologic samples were collected from root canals and quantified for of E. faecalis colony‐forming units (CFUs). The effectiveness of CH over E. faecalis biofilms was further measured using the MBEC Assay®. Additionally, dentine beams and dentine powder were obtained, respectively, from crowns and roots of 20 extracted third molars. Dentine samples were treated or not with 17% EDTA and immersed in either CH or W for 1 min. The effects of CH on dentine structure were evaluated by assessment of the modulus of elasticity, endogenous proteolytic activity and biochemical modifications.ResultsThe number of E. faecalis CFUs was significantly lower for samples irrigated with CH and NaClO. No significant differences were found between CH and NaClO treatments. Higher modulus of elasticity and lower proteolytic activity were reported for dentine CH‐treated specimens. Chemical interaction between CH and dentine was observed for samples treated or not with EDTA.ConclusionsPresent findings suggest that CH could be used as an irrigant during root canal treatment with the triple benefit of reducing bacterial activity, mechanically reinforcing dentine and inhibiting dentine proteolytic activity.
Effect of sorbitol on stabilisation of gardenia blue and food 2D/3D printing
Authors: Wu Chaoyang , Xu Liang , Zhu Juncheng , Cheng Yang , Yang Yuxin , Qiao Shihao , Ma Liang , Zhang Yuhao , Wang Hongxia 
Published: August 2023

SummaryThe stability of gardenia blue is challenged under light and heat. Gardenia blue was designed to be stablised using gelatin, magnesium stearate and sorbitol, and the stabilisation effects and food application were investigated. Effect of sorbitol was studied by CIELab colorimeter, particle size meter, SEM, absorbance, FTIR, XRD, Raman spectrum, and rheometer. Appropriate‐content sorbitol could effectively enhance colour, and promote the UV irradiation stability of gardenia blue encapsulated complex systems, which is mainly owing to the hydrogen bonding, electrostatic interactions and hydrophobic interactions among components. These interactions induced by sorbitol also facilitated the shear‐thinning properties and excellent thermal stability of the complex systems. When writing & drawing on food, and 2D/3D printing food, the complex sample demonstrated the clear colour and outstanding effects. The gardenia blue based complex systems provide some reference for stabilising natural functional materials and illustrates potential application value in food decoration and food functionalisation.
Cutaneous immune‐related adverse events from immune checkpoint inhibitor therapy: Moving beyond “maculopapular rash”
Authors: Allais Blair S. , Fay Christopher J. , Kim Daniel Y. , Semenov Yevgeniy R. , LeBoeuf Nicole R. 
Published: August 2023

SummaryUncoupling toxicity from therapeutic effect lies at the foundation of the current state of the field of cutaneous immune‐related adverse events to immune checkpoint inhibitor therapy. This will be achieved through understanding the drivers of toxicity, tumor response, and resistance via large, well‐powered population‐level studies, institutional cohort data, and cellular‐level data. Increasing diagnostic specificity through the application of consensus disease definitions has the power to improve clinical care and each approach to research. Cutaneous immune‐related adverse events are associated with increased survival, and their treatment must invoke the maintenance of a delicate balance between immunosuppression, anti‐tumor effect of immune checkpoint inhibitor therapy, and quality of life. The multidisciplinary care of cancer patients with adverse events is critical to optimizing clinical and translational research outcomes and, as such, dermatologists are vital to moving the study of cutaneous adverse events forward.
Effects of organizational agility on readiness for change in nurses: A cross‐sectional study
Authors: Zeid Mennat Alla G. Abou , Mostafa Boshra , Zoromba Mohamed A. , Abdelnaby Ramy , Elsayed Mohamed , El‐Gazar Heba E. 
Published: August 2023

AbstractAimTo investigate the correlation between organizational agility and nurses' readiness for change.BackgroundThe paradigm of agility in a healthcare organization is a novel concept that embodies the most advantageous organizational status. However, assessing the effects of organizational agility on nurses’ readiness for change has not been previously studied.MethodsThis cross‐sectional study was conducted on 270 nurses working in a university hospital in Egypt. The study took place between January ‐ March 2022, and participation was voluntary. Data were collected using the organizational agility scale and individual readiness for change scales. Data analysis was conducted using descriptive statistics, Pearson correlation, and structured equation modeling (SEM).ResultsThe results indicated that nurses in the hospital exhibited a moderate level of agility. Nurses’ readiness for change is high. The SEM showed that organizational agility accounted for 64% of the variance in nurses’ readiness for change.ConclusionsOrganizational agility is a significant predictor of nurses’ readiness for change.Implications for nursing policymakingAs a means of ensuring that nurses are prepared for changes, nursing institutions should foster agility by instilling a vision for the future, enhancing staff capabilities, encouraging teamwork and open communication, and implementing total quality management, strategic planning, advanced nursing practice, participatory management, shared decision‐making, and policy development.