bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phototherapy improves cognitive function in dementia: A systematic review and meta‐analysis
Authors: Lu Xinlian , Liu Chengyu , Shao Feng 
Published: April 2023

AbstractThis study aimed to investigate the effectiveness of phototherapy intervention on cognitive function in older adult patients with dementia. PubMed, Ovid MEDLINE, Web of Science, EMBASE, Cochrane Central Registry of Controlled Trials, PsycINFO, and Clinical Trials were searched from their inception to August 10, 2022, for randomized controlled trials involving patients with dementia who received phototherapy interventions. We used the weighted mean difference (MD) or standard weighted mean difference to generate the pooled estimates. The primary outcome was cognitive function as measured by the Mini‐Mental State Examination (MMSE) score. The secondary outcomes were the behavioral and psychological symptoms of dementia (BPSDs) and sleep. This systematic review and meta‐analysis was registered in PROSPERO (registration number: CRD42022343788). We included 12 randomized controlled trials comprising 766 patients with dementia (426 patients in the intervention group and 340 in the control group). Phototherapy interventions significantly improved MMSE scores (n = 3, MD 2.68, 95% confidence interval [CI]: 1.38–3.98, I2 = 0%). There were no significant differences in the Cornell Scale for Depression in Dementia score, Cohen‐Mansfield Agitation Inventory score (MD: −3.12, 95% CI: −8.05, 1.82, I2 = 0%), Neuropsychiatric Inventory score, sleep efficiency, total sleep time, and Sleep Disorders Inventory score between the groups. Our systematic review and meta‐analysis showed that phototherapy significantly improved cognitive function in patients with dementia.
Quantitative coronary three‐dimensional geometry and its association with atherosclerotic disease burden and composition
Authors: Prado Guy F. A. , Blanco Pablo J. , Bulant Carlos A. , Ares Gonzalo D. , Mariani Jose , Caixeta Adriano , Almeida Breno O. , Garzon Stefano , Pinton Fábio A. , Barbato Emanuele , Ribichini Flavio L. , Toth Gabor G. , Mahfoud Felix , Wijns William , Garcia‐Garcia Hector M. , Lemos Pedro A. 
Published: April 2023

AbstractBackgroundIsolate features of the coronary anatomy have been associated with the pathophysiology of atherosclerotic disease. Computational methods have been described to allow precise quantification of the complex three‐dimensional (3D) coronary geometry. The present study tested whether quantitative parameters that describe the spatial 3D coronary geometry is associated with the extension and composition of the underlying coronary artery disease (CAD).MethodsPatients with CAD scheduled for percutaneous intervention were investigated with coronary computed tomography angiography (CCTA), and invasive coronary angiography, and virtual histology intravascular ultrasound (IVUS‐VH). For all target vessels, 3D centerlines were extracted from CCTA images and processed to quantify 23 geometric indexes, grouped into 3 main categories as follows: (i) length‐based; (ii) curvature‐based, torsion‐based, and curvature/torsion‐combined; (iii) vessel path‐based. The geometric variables were compared with IVUS‐VH parameters assessing the extent and composition of coronary atherosclerosis.ResultsA total of 36 coronary patients (99 vessels) comprised the study population. From the 23 geometric indexes, 18 parameters were significantly (p < 0.05) associated with at least 1 IVUS‐VH parameter at a univariate analysis. All three main geometric categories provided parameters significantly related with atherosclerosis variables. The 3D geometric indexes were associated with the degree of atherosclerotic extension, as well as with plaque composition. Geometric features remained significantly associated with all IVUS‐VH parameters even after multivariate adjustment for clinical characteristics.ConclusionsQuantitative 3D vessel morphology emerges as a relevant factor associated with atherosclerosis in patients with established CAD.
Conversion of Methanol into Hydrocarbons over Biomass‐Assisted ZSM‐5 Zeolites: Effect of the Biomass Nature
Authors: Zheng Qianwen , Louis Benoît 
Published: April 2023

AbstractBiomass waste was revealed to act as a promising bio‐template to modify and possibly tailor the zeolite intrinsic properties: texture, crystallinity and acidity. According to the “bio‐sourced secondary template (BSST)” concept, 7 types of abundant biomasses (lignin, oxidized lignin, coffee bagasse, spent tea leaves and three kinds of algae) were selected and their role was evaluated in the zeolite crystallization. As‐synthesized biomass‐assisted ZSM‐5 zeolites were characterized by XRD, SEM, BET and NH3‐TPD techniques to investigate the effects of biomass extra‐addition. The results showed that mainly surface acidic properties were impacted by the presence of biomass. Among them, spent tea leaves‐mediated ZSM‐5 (named A‐tea) exhibited a high catalytic performance in the methanol‐to‐olefins reaction (MTO), with full methanol conversion for more than 50 h at 83 % selectivity towards light olefins, probably due to its mild acidity. Besides, more acidic ZSM‐5 zeolites obtained using three algae (algaCM, algaTM and algaBB), according to the B‐method, demonstrated a methanol conversion superior to 50 % during 75, 94 and 134 h, respectively. This study led to synthesize potential catalysts exhibiting a high MTO catalytic performance, as well as providing hints for future investigations aiming to control zeolite nucleation and growth following the BSST strategy.
Polarity and Dielectric Property Control Triggered by a Coordinated Solvent Molecule Exchange in Luminescent Mononuclear Aluminium(III) Complexes
Authors: Kobayashi Fumiya , Gemba Misato , Hoshino Shoma , Tsukiyama Koichi , Shiotsuka Michito , Nakajima Takashi , Tadokoro Makoto 
Published: April 2023

AbstractThe development of molecule‐based multifunctional switchable materials that exhibit a switch of polarity and dielectric property are extremely limited. We have demonstrated solvent‐vapour‐induced reversible molecular rearrangements between nonpolar crystals [Al(sap)(acac)(sol)] (H2sap=2‐salicylideneaminophenol, acac=acetylacetonate, sol=MeOH (1), EtOH (2)) and polar crystal [Al(sap)(acac)(DMSO)] (3). This crystal‐to‐crystal structural transformation was accompanied by a switch of second harmonic generation (SHG) and dielectric properties, including the formation of ferroelectric domains, thus reflecting the SHG‐active polar Cc space group of 3. This is the first reported example of dielectric properties and polarity switching in luminescent mononuclear aluminium(III) complexes, which exhibit strong green emission in the solid state.
Converging Stereodivergent Reactions: Highly Stereoselective Formalanti‐Markovnikov Addition of H2O to Mixtures of Olefins
Authors: Höthker Sebastian , Mika Regine , Goli Harie , Gansäuer Andreas 
Published: April 2023

AbstractWe describe a highly diastereo‐ and enantioselective two‐step formalanti‐Markovnikov addition of H2O to diastereomeric mixtures of trisubstituted olefins. Our approach overcomes the limits of classical stereospecific addition reactions to olefins for the generation of adjacent stereocenters. In these stereospecific reactions, separation of olefin diastereomers is essential. Our method circumvents the need for such difficult separations by simultaneously employing both diastereomeric olefins in the organocatalytic, highly enantioselective,syn‐specificShi‐epoxidation to yield diastereomeric oxiranes. The stereochemical model proposes the smallest substituent on the olefin to be stereodefining resulting in an identical enantiotopic approach for both olefin isomers on the less substituted carbon. By employing a stereoconverging epoxide hydrosilylation the identically configured center is retained, while the differing one is converted to a planar radical center that is reduced by asyn‐selective intramolecular hydrogen atom transfer (HAT) from aTi−Hbond. The observed converging behavior can be attributed to a HAT‐preceding directional isomerization step, that interconverts the obtained rotameric radicals which ultimately leads to high to excellent enantiomeric ratios of the final secondary alcohols.
Trends in heart failure prevalence in Japan 2014–2019: a report from healthcare administration databases
Authors: Zhang Ling , Ono Yasuhisa , Qiao Qing , Nagai Toshiyuki 
Published: April 2023

AbstractAimsContemporary estimates of heart failure (HF) prevalence in Japan are scarce. We aimed to estimate HF prevalence and trends in Japan using nationally representative, large administrative claims databases.Methods and resultsThis retrospective analysis used data from the Japan Medical Data Center (JMDC) (age ≤74 years) and the Medical Data Vision (MDV) (all ages) databases (study period: 1 January 2014–31 December 31 2019). We calculated HF prevalence using crude and sex‐/age‐standardized models (weighting based on Japanese census data, 2014–2019). Among 8 954 313 individuals aged ≤74 years from JMDC, and 27 920 174 of all ages from MDV, the cumulative 6 year (2014–2019) crude and sex‐/age‐standardized prevalence of HF per 1000 persons (95% confidence intervals) in Japan was 21.80 [21.70, 21.89] and 41.79 [30.25, 56.11] using JMDC and 65.09 [65.00, 65.18] and 60.95 [46.94, 77.62], respectively, using MDV. We observed an increasing yearly trend in crude HF prevalence per 1000 persons: 11.12 in 2014 and 14.69 in 2019 for JMDC; 58.09 and 77.18, respectively, for MDV. There was an overall increasing trend of comorbidities over time (2014–2019) among HF patients, especially in type 2 diabetes, malignant cancer, chronic kidney disease, and atrial fibrillation. From 2014 to 2019, the percentage of patients in JMDC with type 2 diabetes increased from 15.4% to 20.8% and 23.4% to 31.5% in MDV; malignant cancer frequency increased from 16.5% to 20.1% in JMDC and 18.8% to 23.9% in MDV; frequency of chronic kidney disease increased from 14.8% to 17.7% in JMDC and 18.2% to 22.7% in MDV; and frequency of atrial fibrillation increased from 13.6% to 15.6% in JMDC and 23.8% to 29.0% in MDV.ConclusionsWe estimated that the prevalence of HF in Japan was 2.2–3.7% for patients aged ≤74 during the period 2014–2019 using the JMDC database, while the prevalence for patients of all ages was 6.5% using the MDV database.
New Trends in Asymmetric Phase Transfer Catalysis
Authors: Albanese Domenico C. M. , Penso Michele 
Published: April 2023

AbstractPhase Transfer Catalysis (PTC) is a powerful tool to perform reactions in a practical fashion, both in laboratory and industrial scale. Significant cost savings and major process improvements can be achieved in reactions performed under PTC conditions. In the last few years remarkable results in stereoselective reactions were achieved using chiral, non‐racemic quaternary ammonium salts. Moreover, the use of bulky, chiral phosphate anions paired with achiral cations to generate lipophilic ion pairs allowed to design new avenues for the stereoselective construction of important building blocks. Hydrogen bond interactions were also shown to provide new pathways for asymmetric nucleophilic substitutions using insoluble reagents under PTC conditions. This Review will focus on recent advances in developing practical synthetic routes to construct molecules in a stereoselective fashion under PTC conditions.
Lipidomic study and diagnosis of hepatocellular carcinoma tumor with rapid evaporative ionization mass spectrometry
Authors: Wang Haixing , Li Ting , Shen Qing , Liu Zhifang , Chen You‐Wei , Huang Darong , Yu Jiancheng , Wang Long 
Published: April 2023

AbstractLiver cancer is generally considered the leading cause of cancer deaths worldwide, and hepatocellular carcinoma (HCC) contributes to more than 90% of liver cancers. The altered lipid metabolism for rapid cancer cell growth and tumor formation has been frequently proven. In this study, an ambient ionization mass spectrometry technique, rapid evaporative ionization mass spectrometry (REIMS) using a monopolar electric knife, called iKnife, was systematically optimized and employed for ex vivo analysis of 12 human HCC tumor tissue specimens together with the paired paracancerous tissue (PT) and noncancerous liver tissue (NCT) specimens. Nine free fatty acids and 34 phospholipids were tentatively identified according to their extract masses and/or tandem mass spectra. With the help of statistical methods, 7 free fatty acids and 10 phospholipids were distributed differently in 3 types of liver tissue specimens (95% confidence interval). The box plots showed these characterized lipid metabolites varied in PT, HCC, and NCT. Compared with PT and NCT, the upregulations of four common fatty acids FA 18:0, FA 20:4, FA 16:0, and FA 18:1, together with phospholipids PC 36:1, PE 38:3, PE (18:0/20:4), PA (O‐36:1), PC (32:1), PC 32:0, PE 34:0, and PC (16:0/18:1), were found in HCC specimens. The sensitivity and specificity of the established statistic model for real‐time HCC tumor diagnosis were 100% and 90.5%, respectively. This study demonstrated that the described REIMS technique is a potential method for rapid lipidomic analysis and characterization of HCC tumor tissue.
On the Structure–Odor Correlation of Muguet Aldehydes: Synthesis of 3‐(4’‐Isobutyl‐2’‐methylphenyl)propanal (Nympheal) and Four Novel Derivatives from a Hagemann’s Ester
Authors: Ohrmann Eva , Chandrasekaran Vijayanand , Hölscher Bernd , Kraft Philip 
Published: April 2023

AbstractLilybelle and Biomuguet are currently the only renewable and biodegradable non‐spermotoxic Lilial replacers. Being non‐aromatic, these lack however some of the green, aquatic aspects of Lilial that are present in the captive odorant Nympheal, 3‐(4‐isobutyl‐2‐methylphenyl)propanal, which is not available from renewable resources. Therefore, the influence of the aromatic nucleus on the odor of four new hydrogenated Nympheal derivatives was investigated, which were all accessible from the isobutyl Hagemann’s ester that was synthesized in 75 % yield from isovaleraldehyde with two equivalents of ethyl acetoacetate. The respective Hagemann’s ester was alkylated with 3‐bromopropanal dimethyl acetal and subjected to decarboxylative saponification, followed by hydride reduction and dehydration through the corresponding mesylate to furnish, after deprotection with formic acid, the corresponding exo‐ and endo‐dihydro‐Nympheal derivative. Full or partial hydrogenation of the central acetal‐protected intermediate provided after deprotection the analogous fully saturated analogue or the cyclohexene derivative. The olfactory properties of these four novel Nympheal derivatives are discussed and rationalized by computational olfactophore models.
Ovarian reserve in patients with multiple sclerosis: A systematic review and meta‐analysis
Authors: Carbone Luigi , Di Girolamo Raffaella , Conforti Alessandro , Iorio Giuseppe Gabriele , Simeon Vittorio , Landi Doriana , Marfia Girolama Alessandra , Lanzillo Roberta , Alviggi Carlo 
Published: April 2023

AbstractObjectiveTo summarize recent evidence about ovarian reserve markers in women affected by multiple sclerosis (MS) compared with healthy controls, as women with MS seem to be characterized by lower anti‐Müllerian hormone (AMH) levels.MethodsThe research was conducted using PubMed (MEDLINE), Scopus, ClinicalTrial.gov, OVID and Cochrane Library from inception of each database to June 30, 2022. Studies comparing ovarian reserve markers between women with MS and healthy controls were considered eligible for inclusion. The primary outcome was serum AMH (ng/mL) levels. Results were reported as pooled odds ratio (OR) for categorical outcomes and as mean difference (MD) for continuous variables, with their 95% confidence intervals (CIs). The random effect model of DerSimonian and Laird was adopted for all analyses. A P‐value less than 0.05 was considered significant.ResultsSerum AMH circulating levels were not significantly different (MD −0.25, 95% CI −0.83 to 0.32; P = 0.390), as well as blood levels of follicle‐stimulating hormone or ovarian volume. However, antral follicle count (AFC) and estradiol blood levels were significantly lower, and luteinizing hormone (LH) levels were significantly higher in women with MS than in controls.ConclusionA significant difference in AFC, estradiol and LH levels was observed, but not for AMH levels.
Guidelines on the Use of Therapeutic Apheresis in Clinical Practice – Evidence‐Based Approach from the Writing Committee of the American Society for Apheresis: The Ninth Special Issue
Authors: Connelly‐Smith Laura , Alquist Caroline R. , Aqui Nicole A. , Hofmann Jan C. , Klingel Reinhard , Onwuemene Oluwatoyosi A. , Patriquin Christopher J. , Pham Huy P. , Sanchez Amber P. , Schneiderman Jennifer , Witt Volker , Zantek Nicole D. , Dunbar Nancy M. 
Published: April 2023

AbstractThe American Society for Apheresis (ASFA)Journal of Clinical Apheresis(JCA) Special Issue Writing Committee is charged with reviewing, updating, and categorizing indications for the evidence‐based use of therapeutic apheresis (TA) in human disease. In the Ninth Edition, the JCA Special Issue Writing Committee has incorporated systematic review and evidence‐based approaches in the grading of evidence and categorization of apheresis indications to make recommendations on the use of apheresis in a wide variety of diseases and conditions. This edition has largely maintained the general layout and concept of a fact sheet introduced in the Fourth Edition (2007). Each fact sheet succinctly summarizes the evidence for the use of TA in a specific disease or medical condition. The Ninth Edition of the JCA Special Issue comprises 91 fact sheets and 166 graded and categorized indications. This includes seven new fact sheets, nine new indications on existing fact sheets, and eight changes in the category for existing indications. The Ninth Edition of the JCA Special Issue seeks to continue to serve as a key resource that guides the utilization of TA in the treatment of human disease.
Ultrasonic‐assisted glycosylation with κ‐carrageenan on the functional and structural properties of fish gelatin
Authors: Ding Keying , Geng Hulin , Guo Wenwen , Sun Wanyi , Zhan Shengnan , Lou Qiaoming , Huang Tao 
Published: April 2023

AbstractBACKGROUNDFish gelatin (FG) has multifunctional properties similar to mammalian gelatin (MG), and it has been recognized as the optimal alternative to MG. While its poor surface‐active and gelling properties significantly limit its application values, glycosylation has been successfully used to increase surface‐active properties of FG, but the influence of ultrasonic‐associated glycosylation (UAG) on the gelling and structural characteristics of FG is still rarely reported. This article explores UAG (100–200 W, 0.5–1 h) with κ‐carrageenan (κC) on the functional properties (emulsifying, gelling and rheological properties) and structural characteristics of FG.RESULTSThe longer time and higher power of ultrasonics accelerated the glycosylation reaction with an increase in glycosylation degree and browning index values. Compared with original FG, FG–κC mixture and bovine gelatin, UAG‐modified FG possessed higher emulsification activity index, emulsion stability index, gel strength, hardness and melting temperature values. Among them, gelatin modified by appropriate ultrasonic conditions (200 W, 0.5 h) had the highest emulsifying and gelling properties. Rheological results showed that UAG contributed to the gelation process of gelatin with advanced gelation time and endowed it with high viscosity. Structural analysis indicated that UAG promoted κC to link with FG by the formation of covalent and hydrogen bonds, restricting more bound and immobilized water in the gels, exhibiting higher gelling properties.CONCLUSIONThis work showed that UAG with κC is a promising method to produce high gelling and emulsifying properties of FG that could replace MG. © 2023 Society of Chemical Industry.
Enabling cryo‐EM density interpretation from yeast native cell extracts by proteomics data and AlphaFold structures
Authors: Tüting Christian , Schmidt Lisa , Skalidis Ioannis , Sinz Andrea , Kastritis Panagiotis L. 
Published: April 2023

AbstractIn the cellular context, proteins participate in communities to perform their function. The detection and identification of these communities as well as in‐community interactions has long been the subject of investigation, mainly through proteomics analysis with mass spectrometry. With the advent of cryogenic electron microscopy and the “resolution revolution,” their visualization has recently been made possible, even in complex, native samples. The advances in both fields have resulted in the generation of large amounts of data, whose analysis requires advanced computation, often employing machine learning approaches to reach the desired outcome. In this work, we first performed a robust proteomics analysis of mass spectrometry (MS) data derived from a yeast native cell extract and used this information to identify protein communities and inter‐protein interactions. Cryo‐EM analysis of the cell extract provided a reconstruction of a biomolecule at medium resolution (∼8 Å (FSC = 0.143)). Utilizing MS‐derived proteomics data and systematic fitting of AlphaFold‐predicted atomic models, this density was assigned to the 2.6 MDa complex of yeast fatty acid synthase. Our proposed workflow identifies protein complexes in native cell extracts fromSaccharomyces cerevisiaeby combining proteomics, cryo‐EM, and AI‐guided protein structure prediction.
M2 Macrophage Membrane‐Mediated Biomimetic‐Nanoparticle Carrying COX‐siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation
Authors: Sun Jie , Ju Fei , Jin Jing , Wang Hao Liang , Li Zhi Jie , Sun Yu Cheng , Chen Qing Zhong , Yang Qian Qian , Tan Jun , Zhou You Lang 
Published: April 2023

AbstractTendon adhesion is the most common outcome of tendon or tendon‐to‐bone healing after injury. Our group developed a hydrogel‐nanoparticle sustained‐release system previously to inhibit cyclooxygenases (COXs) expression and consequently prevent tendon adhesion and achieved satisfactory results. However, effective treatment of multiple tendon adhesions is always a challenge in research on the prevention of tendon adhesion. In the present study, an M2M@PLGA/COX‐siRNA delivery system is successfully constructed using the cell membranes of M2 macrophages and poly (lactic‐co‐glycolic acid) (PLGA) nanoparticles. Targeting properties and therapeutic effects are observed in mice or rat models of flexor digitorum longus (FDL) tendon injury combined with rotator cuff injury. The results showed that the M2M@PLGA/COX‐siRNA delivery system has low toxicity and remarkable targeting properties to the injured areas. Treatment with the M2M@PLGA/COX‐siRNA delivery system reduced the inflammatory reaction and significantly improved tendon adhesion in both the FDL tendon and rotator cuff tissues. These findings indicate that the M2M@PLGA delivery system can provide an effective biological strategy for preventing multiple tendon adhesions.