bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acquired renal arteriovenous malformation: the diagnostic value of three-dimensional multidetector-row computed tomography ⁎
Authors: Wang Qiuxia , Chen Liang , Hu Xuemei , Hu Yao , Hu Daoyu , Li Zhen 
Published: June 2023

Abstract

Objective
To evaluate the diagnostic value of three-dimensional multidetector-row computed tomography (MDCT) in detecting acquired renal arteriovenous malformation (RAVM) and to compare its performance with that of ultrasonography and digital subtraction angiography (DSA).

Methods
The institutional review board approved this retrospective study and written informed consent was obtained from all patients before examination. All 14 patients with acquired RAVM underwent MDCT, including cortical and medullary phase enhancement angiography and three-dimensional (3D) reconstruction. Five and nine patients were further examined and their diagnoses confirmed by DSA and surgery, respectively. The MDCT images, including 3D reconstructions, were analyzed for RAVM independently and in consensus by two observers using a workstation.

Results
Among the 14 patients with acquired RAVM, 12 with maximum lesion diameter ≥ 10 mm, and one with a maximum lesion diameter between 5 and 10 mm, were correctly diagnosed with MDCT angiography. Among these patients, four diagnoses were confirmed by DSA. One patient with a lesion 5-10 mm in diameter was misdiagnosed with a renal aneurysm by MDCT angiography. The other one with the maximum diameter of the lesion between 5 mm and 10 mm was misdiagnosed as renal aneurysm with MDCT angiography, which was diagnosed as renal arteriovenous malformation with DSA. Among 14 lesions in 14 patients, eight and six originated in the left and right kidney, respectively.

Conclusion
MDCT angiography can accurately diagnose RAVM and improve our understanding of the disease, which will allow clinicians to provide better care.
The preoperative neutrophil-to-lymphocyte ratio predicts the outcomes of patients with hepatocellular carcinoma and cirrhosis after hepatectomy ⁎
Authors: Hua Yunpeng , Ji Fei , Fu Shunjun , Shen Shunli , Li Shaoqiang , Liang Lijian , Peng Baogan 
Published: June 2023

Abstract

Objective
The aim of the study was to investigate the prognostic value of the preoperative peripheral neutrophil-to-lymphocyte ratio (NLR) in patients with hepatocellular cancer (HCC) and cirrhosis after hepatectomy.

Methods
This retrospective study included 321 patients with HCC who underwent resection. The NLR was calculated using the neutrophil and lymphocyte counts in routine preoperative blood tests. Receiver operating characteristic curve analysis was performed to select the most appropriate NLR cutoff value. The preoperative NLR, patient demographics, and clinical and pathological data, including disease-free survival (DFS) and overall survival (OS), were analyzed.

Results
The NLR was correlated with alpha-fetoprotein levels (χ2 = 5.876, P = 0.015), tumor size (χ2 = 32.046, P < 0.001), portal vein tumor thrombus (PVTT; χ2 = 4.930, P = 0.026), tumor encapsulation (χ2 = 7.243, P = 0.007), and recurrence (χ2 = 7.717, P = 0.005). Multivariate analyses illustrated that the number of tumors, PVTT, tumor size, and the NLR were independent factors for predicting DFS and OS. In patients with HCC and cirrhosis, but not among those without cirrhosis, a larger NLR predicted poorer postoperative DFS and OS (both P < 0.001).

Conclusion
As a simple, effective independent predictor for patients with HCC, the preoperative NLR plays an important role in accurately predicting the postoperative outcomes of patients with HCC and cirrhosis, but not those of patients without cirrhosis.
Feasibility and reliability of the revised Edmonton Symptom Assessment System (ESAS-r) in Egyptian patients with advanced cancer: A single institutional experience
Authors: Salem Dina A. , Adel Azza M. , Essa Ahmed E. , Alorabi Mohamed O. , Elsayed Zeinab M. 
Published: June 2023

Abstract

Objective
This study aims to test the acceptance, feasibility, and usefulness of the Arabic version of the revised Edmonton Symptom Assessment System (ESAS-r) among Egyptian patients with advanced cancer and to compare the rates of symptoms documented by patients and physicians.

Methods
Between August 2014 and February 2015, a total of 140 patients at Ain Shams University Hospitals in Cairo, Egypt received the Arabic version of the ESAS-r. For each patient, the ESAS-r was completed twice, first by the treating physician (as part of the basic assessment) and a second time by the patient, with a maximum of 2 hours between the two assessments. An additional survey was included to assess patients’ acceptance of the survey and their preferences.

Results
Out of 140 enrolled patients in the study, 11 patients refused to complete the questionnaire, and 10 patients were excluded due to incomplete records in their medical records. Complete data was retrieved for 119 patients who were included for further analyses. The 78 (65%) patients declared that the test was clear and easy to complete. They were able to answer the test without help. Collectively, tiredness and sense of well-being were the most commonly encountered symptoms in ratings obtained by both patients and physicians. Tiredness was the only symptom showing a significant difference between the two rating methods, patient-rated scores being higher (P = 0.032). Cronbach’s alpha showed that both tests completed by the physician and the patients were internally consistent: the physician-rated test had a coefficient of 0.877, and the patient-rated test had a coefficient of 0.863. All ESAS scores had good internal consistency, with a Cronbach’s alpha coefficient of 0.88. The internal consistency remained high after removal of individual symptom scores, with Cronbach’s alpha coefficients ranging from 0.823 to 0.902, indicating that no individual question had undue influence on the total ESAS score.

Conclusion
The ESAS-r was easily understood by and applicable to patients. There was no significant discrepancy in the rates of symptoms reported by the patients and physicians, apart from tiredness. Based on this, the test could be applied on a larger scale with in-home patients. This test can be cost-effective and can decrease the number of hospital visits among advanced cancer patients in need of supportive treatment rather than active cancer therapy.
Epidermal growth factor receptor: a key manipulator in molecular pathways of malignant glioma
Authors: Ke Changshu 
Published: June 2023

Abstract
The epidermal growth factor receptor (EGFR) is a member of the ErbB/EGFR family, including EGFR/Her1, ErbB2/Her2, ErbB-3/Her3, and ErbB-4/Her4. EGFR exerts its effects through the receptor tyrosine kinase phosphorylation and activation of important downstream signaling pathways in normal and neoplastic cells, mainly the Ras GTPase/MAP kinase (MAPK), STAT3, and phosphatidylinositide 3 kinase-AKT pathways. EGFR deregulation is common in malignant glioma, especially primary glioblastoma, and exists in three forms: gene overexpression (amplification), autocrine effects of EGFR activation, and activating receptor mutation (EGFRvIII). However, some EGFR abnormalities have also been found in low-grade gliomas, including the nuclear localization of EGFR, expression in the microfoci of anaplastic transformation, and association with neovascularization in the mesenchyma of the glioma, which suggests that some unknown EGFR-related mechanisms are possibly responsible for its central role in the initiation and progression of malignant glioma. Uncovering these mechanisms will have potential value in the development of radiotherapy, chemotherapy, and EGFR-targeted therapy for glioma.
Clinical significance of HBME-1, Galectin-3, and CK19 expression and the status of BRAF mutation in papillary thyroid carcinoma
Authors: Zheng Li , Zhao Min , Hu Xiangyang , Huang Jin , Ang Ling , Hu Hongguang , Zou Qiang , Wang Jin , Liu Mingqiang , Zhao Yang 
Published: June 2023

Abstract

Objective
The aim of this study was to explore the clinical significance of the expression of proteins human bone marrow endothelial cell markers (HBME-1), Galectin-3, and cytokeratin19 (CK19), as well as the status of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutation in papillary thyroid carcinoma (PTC).

Methods
Immunohistochemical staining was performed in 82 specimens each of PTC and papillary benign lesions to detect the expression of HBME-1, Galectin-3, and CK19. Polymerase chain reaction (PCR) and gene sequencing were performed on 60 specimens each of PTC and papillary benign lesions to detect the status of BRAF mutation.

Results
The positive expression ratios of HBME-1, Galectin-3, and CK19 in PTC were 98.8%, 97.6% and 100% respectively, which were significantly higher than the expressions in papillary benign lesions (P < 0.05). No significant relationship was observed between the expression of these makers and the clinicopathological features of PTC. The sensitivity of co-expression of HBME-1 and CK19 or HBME-1 and Galectin-3 as diagnostic criteria of PTC was 99.9%, with a specificity of 95.4%. BRAF mutation was detected in 40 of 60 PTC (66.7%) specimens. There was a statistical difference in BRAF mutations between PTC and papillary benign lesions (P < 0.05); there were no associations between BRAF mutation and the clinicopathological features of PTC.

Conclusion
Combined immunohistochemical staining of HBME-1, Galectin-3, and CK19 can further improve the sensitivity and specificity of differential diagnosis of PTC. BRAF mutation is a significant genetic event, which may have diagnostic value for PTC.
Management of bone tumor
Authors: Guan Hanfeng , Li Feng 
Published: June 2023

Feng Li,
Professor of Orthopedics, Doctoral Supervisor, Director of the Orthopedics Department, Tongji Hospital, Tongji Medical College of HUST, China. He entered Tongji Medical College and completed the medical curriculum in 1985. Afterwards, he became a surgeon in the Orthopedics Department of Tongji Hospital. He received a Medical Doctor degree at Tongji Medical College in 1993. He had postdoctoral training at University of Bern, Switzerland from 1996 to 1998. In 2008, he visited Washington University in St. Louis, USA as a guest Professor.
His major interest is spine surgery especially cervical spine surgery. He constantly tries to improve surgical strategies in order to provide better treatment for patients. For surgeries involving C1 and C2 cervical vertebrae, he introduced a video-assisted anterior transcervical approach, serving as a viable alternative to the traditional transoral approach. he modified the surgical approach for the posterior cervical spine surgery. These modifications enable the surgery to be less invasive and provide the patients with fast postoperative recovery and better quality of life.
He has been an active investigator of research on osteoporosis and degeneration of human spine for more than 15 years. He published more than 200 peer-reviewed papers in national and international journals including Nature, JBMR, Spine, Oncogenesis, Sci rep, Medicine, Cell Signal. He is an academic editor for several journals. Dr. Li serves as the chairman of the spine surgery group of Hubei Province Orthopedic Association. He is also a member of multiple orthopedic society.
Precision medicine in the treatment of pancreatic ductal adenocarcinoma
Authors: Chen Jianlin , Chu Yunmian , He Jin , Zheng Lei , Che Xu 
Published: June 2023

Abstract
Pancreatic cancer has a poor prognosis. Current therapies for pancreatic cancer have limited effects. In the past decade, precision medicine has shown great potential for clinical applications. In this review, different strategies for applying precision medicine to the treatment of pancreatic cancer are described.
Primary malignant melanoma of the liver: One case report and literature review
Authors: Huang Dongfang , Wu Jinsheng , Chen Guofeng , Zhang Jianhuai 
Published: June 2023

Abstract

Objective
Primary malignant melanomas of the liver are exceedingly rare. Only 19 cases have been reported in the literature worldwide. In this report, we describe our pathological findings and review the literature in order to improve our understanding of the disease and prevent misdiagnosis, as well as provide evidence for its treatment and prognosis.

Methods
We present a case of an isolated malignant melanoma of the liver in a 61-year-old male Chinese patient.

Results
Comprehensive dermatological and ophthalmological examinations did not reveal any evidence of a primary cutaneous or ocular lesion. Similarly, serial physical examinations, auxiliary examinations, and bone scans did not demonstrate any other lesions in the brain, respiratory tract, and gastrointestinal tract. Microscopic examination of the resected specimen revealed malignant melanoma, which was confirmed by immunohistochemical staining for S-100 protein (+), ki67 (30%+), EMA (+), CD10 (+), and HMB-45 (++).

Conclusion
Primary malignant melanoma may occur in the liver, and should be considered when the histopathological appearance is atypical of other hepatic neoplasms. The diagnostic criteria for hepatic malignant melanoma depend mainly on the clinical, radiographic, and histopathological findings. Pathomorphology and immumohistochemical staining can be utilized to confirm the diagnosis.
Relationship between peritumoral lymphatic microvessel density and the clinical and pathological characteristics of invasive breast cancer
Authors: Qu Shuxian , Liu Yongming , Liu Zhaozhe , Liu Liang , Han Yaling , Xie Xiaodong , Zheng Zhendong 
Published: June 2023

Abstract

Objective
The aim of the study was to determine the morphological characteristics of lymphatic microvessels and the relationship between lymphatic microvessel density (LMVD) and clinical and pathological characteristics of invasive breast cancer.

Methods
Tissue specimens and clinical pathological data of 51 cases of female breast cancer were collected in the General Hospital of Shenyang Military Region (Shenyang, China) from January 2007 to October 2011. Another 20 breast fibroadenoma tissue samples were used as controls. All specimens were cut into 4-μm slices, and immunohistochemically stained using streptomycin-resistant avidin peroxidase antibody D2-40. SPSS 17.0 for Windows was used to perform all analyses.

Results
A total of 38 breast cancer tissue specimens showed varied staining with monoclonal antibody D2-40. The rate of positive staining was in these tissues was 74.5% (38/51), which is significantly higher than that observed in breast fibroadenoma tissues (chi-square = 35.197, P = 0.000). The average LMVD in 38 cases of breast cancer was (26.46 ± 10.06) microvessels/100× magnification field, which was higher than that in the control group (t = 10.74, P = 0.000). Microvessels in peritumoral tissues were abundant, with an average LMVD of (38.42 ± 11.38) microvessels/100× magnification field. Based on layered analysis, the expression level of peritumoral LMVD was correlated with metastasis of lymph nodes, tumor size, and the expression of C-erbB-2 (P < 0.05); however, there was no correlation with age or expression of estrogen receptors or progesterone receptors (P > 0.05).

Conclusion
Lymphatic microvessels detected using D2-40 antibody are mainly present in the peritumoral region of breast cancer tissues, and LMVD showed a correlation with lymph node metastasis and the expression of C-erbB-2. Positive lymphatic vessels, especially in the peritumoral region, may provide a path for lymphatic metastasis in breast cancer. Peritumoral LMVD may be used to estimate the prognosis of patients with breast cancer and may aid in research on treatment methods.
A case of chronic pancreatitis treated by laparoscopic duodenum-preserving pancreatic head resection
Authors: Ma Chunyang , Xiao Guangqin , Zhu Feng , Peng Feng , Guo Xingjun , Gao Hengyi , Ren Yuqi , Wang Hebin , Wang Min , Qin Renyi 
Published: June 2023

Abstract
Pancreaticoduodenectomy (PD) has long been used for chronic pancreatitis (CP), but greatly affects the postoperative quality of life. A new procedure called duodenum-preserving pancreatic head resection (DPPHR) has been introduced, and has little effect on the structure and function of the digestive system. With the development of minimally invasive surgical techniques, treatment of CP can be performed with laparoscopic DPPHR (LDPPHR). We present a case of CP that was successfully treated with LDPPHR. The postoperative pathological diagnosis was pancreatitis, demonstrating the feasibility of LDPPHR. We recommend this minimally invasive surgical method as preferred treatment for CP.
Laparoscopic middle pancreatectomy
Authors: Guo Xingjun , Qin Renyi 
Published: June 2023

Abstract
Pancreaticoduodenectomy and distal pancreatectomy are the traditional surgical treatments of tumors in the neck or body of the pancreas. Although resecting the lesions successfully, these procedures can also, however, lead the substantial loss of normal pancreatic parenchyma, causing endocrine and exocrine function disorder. The combination of distal pancreatectomy with splenectomy increased the risk of thrombosis sometimes. So the surgical trauma is too great, especially for benign and lower malignant tumors located in the neck or body of the pancreas. While, middle pancreatectomy may decrease operative trauma with the excision of these lesions, and can maximize the retention of pancreatic parenchyma, and maintain pancreatic endocrine and exocrine function integrity. The procedure is interesting but rarely performed. With the application and development of minimally invasive surgical techniques, laparoscopic and robotic middle pancreatectomy are available now. Researches about laparoscopic and robotic middle pancreatectomy are presented, with decreased morbidity, reduced operation time and hospital stay. There is only a few reports on the two procedures, but the security and effectiveness of them are suggested.
Circulating biomarkers for nonfunctional gastroenteropancreatic neuroendocrine neoplasm: Where do we stand?
Authors: Zhang Panpan , Shen Lin 
Published: June 2023

Abstract
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) encompass a heterogeneous group of tumors associated with variable presentations, growth rates, and prognoses. The majority of GEP-NENs are nonfunctional, and their diagnosis remains challenging given the often subtle and variable clinical manifestations of these tumors. As a consequence, GEP-NENs are often recognized at an advanced stage; indeed, most patients with nonfunctional GEP-NENs exhibit metastatic disease at diagnosis. Lack of treatment options as well as limitations in currently available imaging modalities and biomarkers make it challenging to manage NENs. Thus, novel biomarkers are needed to provide high sensitivity and specificity for minimum disease detection and to predict treatment efficacy and prognosis. Although tissue-based biomarker data can provide such information, circulating biomarkers such as NETests, circulating tumor cells, and microR-NAs, are superior owing to their easy accessibility and the ability for repeated real-time sampling.
Multimodal therapy for brain tumors ⁎
Authors: Hu Feng , Lei Ting 
Published: June 2023

Ting Lei. M.D., Professor of Neurosurgery, Doctoral Supervisor, Director of the Neurosurgery Department, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, China. He obtained his bachelor’s and master’s degree from Tongji Medical University, China, and became a neurosurgeon afterward. Then, he successfully obtained a German Academic Exchange Service scholarship to undertake his doctorate in medicine at the University of Erlangen-Nuernberg in Germany. Under the supervision of Profs. R. Fahlbusch and M. Buchfelder, he completed his doctoral degree in the same university and returned to Tongji Hospital to become the first postdoctoral fellow in the Department of Neurosurgery. Since 1998, he has been Chief of the Neurosurgical Department.
His scientific interest is basic research and clinical treatment of brain tumors, including pituitary adenoma and glioma. He introduced transsphenoidal surgery in the treatment of pituitary adenoma in Hubei Province, China. Currently, he performs more than 300 transsphenoidal surgeries annually. Over the past years, he also modified this surgical approach to make it less invasive and provide patients with fast postoperative recovery and better quality of life.
He has been an active researcher in the brain tumor research community for over 30 years now. He received several grants from the National Natural Science Foundation and published more than 500 peer-reviewed papers in national and international journals, including the Journal of Neurosurgery, Epilepsy, European Journal of Cancer, and Cancer Letter. Meanwhile, he is also an academic editor of several journals. Prof. Lei serves as the chairman of the neurosurgery branch of the Wuhan Medical Association and is a committee member of several academic associations.
Ultrasound-guided percutaneous microwave ablation for small liver cancers adjacent to large vessels: long-term outcomes and strategies
Authors: Liu Ruobing , Li Kaiyan , Luo Hongchang , Zhang Wei , Zhang Tingting , Gao Meng , Zha Wenhui , Cui Xinwu , Deng Youbin 
Published: June 2023

Abstract

Objective
The aim of the study was to evaluate the long-term efficacy and safety of percutaneous microwave ablation (MWA) for small hepatic cancers adjacent to large vessels and to investigate the treatment strategies.

Methods
From March 2009 to July 2015, a total of 86 patients with 94 tumors underwent ultrasound (US)-guided percutaneous MWA, with pathologically proven or clinically diagnosed liver cancers measuring ≤ 3 cm in diameter and located ≤ 10 mm from a major vessel (n = 94). Regular follow-up after MWA was performed to assess treatment efficacy and perioperative complications.

Results
The complete ablation rate at 1 month after MWA was 93.3% (84/90). The 6-, 9-, 12-, 24-, 36-, 48-, 60-, 72-, and 84-month local recurrence rates were 2.4%, 2.4%, 3.7%, 6.6%, 8.4%, 8.4%, 8.4%, 8.4%, and 8.4%, respectively. There were no major complications. The perioperative special complication rate was 5.32% (5/94), including 3 cases of moderate liver function damage and 2 cases of limited sub-capsular hematoma.

Conclusion
Percutaneous MWA for small hepatic cancers adjacent to large vessels is feasible, effective, and safe with an acceptable rate of complications. The key point is to strictly follow operative indications and adopt proper treatment strategies.