bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between social media addiction, psychological distress, and food addiction among Taiwanese university students
Authors: Huang Po-Ching , Latner Janet D. , O’Brien Kerry S. , Chang Yen-Ling , Hung Ching-Hsia , Chen Jung-Sheng , Lee Kuo-Hsin , Lin Chung-Ying 
Published: March 2023

Abstract
Background
Worldwide, 60% of people use social media. Excessive and/or addictive use of social media termed “problematic social media use”, has been reported to negatively influence psychological and physiological health. Therefore, we proposed an illustrated model to investigate the associations between social media addiction, psychological distress and food addiction among Taiwanese university students.

Methods
A total of 598 participants (mean age = 22.8 years) completed an online survey comprising the Bergen Social Media Addiction Scale (BSMAS) assessing social media addiction, the Depression Anxiety and Stress Scale (DASS-21) assessing psychological distress, and the Yale Food Addiction Scale 2.0 (YFAS 2.0) assessing food addiction.

Results
Structural equation modeling showed the significant associations between BSMAS and DASS-21 (standardized coefficient [β] = 0.45; p < 0.01) and between DASS-21 and YFAS 2.0 (β = 0.43; p < 0.01). In addition, mediation effect with 100 bootstrapping samples showed the indirect effect of DASS-21 in the association between BSMAS and YFAS 2.0

Conclusions
The present study details the relationships between social media addiction and psychological distress as well as food addiction. The results suggest the need for interventions aimed at reducing these negative outcomes. Coping strategies for improving self-control or reducing weight-related stigma, such as food consumption monitoring or mindfulness, could be adopted for at-risk individuals to address these problems.
Scurvy, abnormal MRI, and gelatinous bone marrow in an adolescent with avoidant restrictive food intake disorder
Authors: Kim Ginny Claire , Davidson Asha M. , Beyda Rebecca M. , Eissa Mona A. 
Published: March 2023

Abstract
Background
Although medical literature describes pediatric scurvy as “rare”, a growing number of case reports suggests otherwise. Patients often undergo costly and unnecessary workup due to unfamiliarity with the presentation of scurvy. This case report further supports the small yet growing literature documenting scurvy and its manifestations in patients with eating disorders.

Case presentation
A 15-year-old female presented to the emergency department with bilateral knee and ankle swelling and pain in the setting of chronic lower limb rash and BMI of 16.3. For years, she had restricted her diet to carbohydrates. Exam showed perifollicular petechial hemorrhagic rash with corkscrew hairs, knee edema, ankle edema with restricted range of motion, and antalgic gait. She was admitted for severe malnutrition from avoidant restrictive food intake disorder. Her hospital course was complicated by recurrent normocytic anemia and fever. Hematology workup revealed anemia from iron deficiency, vitamin K deficiency, and anemia of chronic disease. Rheumatology workup was negative. MRI findings showed dark T1 and bright T2 signals and were read as consistent with leukemia/lymphoma, chronic multifocal osteomyelitis, or Langerhans cell histiocytosis. However, bone marrow biopsy showed gelatinous transformation secondary to malnutrition. She was treated with vitamin C and a nutrition plan and her symptoms improved.

Conclusions
Although this patient had common manifestations of scurvy, including perifollicular petechial hemorrhagic rash, joint effusions, anemia, and recurrent fevers, she still underwent an extensive workup. Clinicians should be aware that scurvy can present with multiple symptoms that mimic infectious, rheumatic, oncologic and hematological disease. Clinicians should have a high index of suspicion for scurvy in patients with malnutrition and eating disorders.
Work-related stress, quality of life, and coping mechanism among lecturers in a Tertiary Educational Institution in Anambra State, Nigeria
Authors: Chukwuemeka Uchechukwu Martha , Okonkwo Uchenna Prosper , Njoku Chibuike Jefferen , Igwe Sylvester Emeka , Oyewumi Taiwo Joseph , Ugwuanyi Daniel Chimmuanya 
Published: March 2023

Abstract
Introduction
Work-related stress (WRS) is a highly prevalent and pervasive problem that can result in loss of productivity and deterioration of a lecturer’s health. Lecturing work requires coping with some of the stressful situations found in any workplace to have a favourable quality of work life. The study determined the influence of sex, years of teaching experience, and academic rank on work-related stress, coping mechanisms, and quality of work life among lecturers at Nnamdi Azikiwe University (NAU).

Method
This was a cross-sectional survey involving 283 lecturers consecutively recruited from NAU after proportionate randomization of the lecturers in 101 departments. The Health and Safety Executive Work Related stress (HSE-WRS), Work-Related Quality of life (WRQL), and Brief-cope Questionnaires (BCQ) were applied to assess the participant’s work-related stress, quality of work life, and coping mechanism (CM) respectively. Data were analyzed using Kruskal Wallis and Mann-Whitney U tests at a 0.05 level of significance.

Result
Sex, years of teaching experience, and academic rank had statistically significant influence on 14 subsets of coping mechanism with p-values </=0.01. Years of teaching experience had a statistically significant influence on work-related stress (p = 0.00). Sex, years of teaching experience, and academic rank did not influence work-related quality of life in a statistically significant way.

Conclusion
There was a statistically significant influence of sex, years of teaching experience, and academic rank on coping strategies of lecturers. Also, a statistically significant influence of years of teaching experience on work related stress of lecturers was ascertained and revealed that male lecturers coped better with the rigorous demands of the job compared to female lecturers.
Diverse environmental cues drive the size of reproductive aggregation in a rheophilic fish
Authors: Šmejkal Marek , Bartoň Daniel , Blabolil Petr , Kolařík Tomáš , Kubečka Jan , Sajdlová Zuzana , Souza Allan T. , Brabec Marek 
Published: March 2023

AbstractBackgroundAnimal migrations are periodic and relatively predictable events, and their precise timing is essential to the reproductive success. Despite large scientific effort in monitoring animal reproductive phenology, identification of complex environmental cues that determine the timing of reproductive migrations and temporal changes in the size of reproductive aggregations in relation to environmental variables is relatively rare in the current scientific literature.MethodsWe tagged and tracked 1702 individuals of asp (Leuciscus aspius), a large minnow species, and monitored with a resolution of one hour the size of their reproductive aggregations (counts of sexes present at the breeding grounds standardized by the sum of individuals in the season) over seven breeding seasons using passive integrated transponder tag systems. We examined the size of reproductive aggregations in relation to environmental cues of day number within a reproductive season (intra-year seasonality), water temperature, discharge, hour in a day (intra-day pattern), temperature difference between water and air, precipitation, atmospheric pressure, wind speed and lunar phase. A generalized additive model integrating evidence from seven breeding seasons and providing typical dynamics of reproductive aggregations was constructed.ResultsWe demonstrated that all environmental cues considered contributed to the changes in the size of reproductive aggregations during breeding season, and that some effects varied during breeding season. Our model explained approximately 50% of the variability in the data and the effects were sex-dependent (models of the same structure were fitted to each sex separately, so that we effectively stratified on sex). The size of reproductive aggregations increased unimodally in response to day in season, correlated positively with water temperature and wind speed, was highest before and after the full moon, and highest at night (interacting with day in a season). Males responded negatively and females positively to increase in atmospheric pressure.ConclusionThe data demonstrate complex utilization of available environmental cues to time reproductive aggregations in freshwater fish and their interactions during the reproductive season. The study highlights the need to acquire diverse data sets consisting of many environmental cues to achieve high accuracy of interpretation of reproductive timing.Graphical abstract
Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer’s disease immunotherapeutics
Authors: Wang Zemin , Jin Ming , Hong Wei , Liu Wen , Reczek David , Lagomarsino Valentina N. , Hu Yuan , Weeden Tim , Frosch Matthew P. , Young-Pearse Tracy L. , Pradier Laurent , Selkoe Dennis , Walsh Dominic M. 
Published: March 2023

AbstractDespite ongoing debate, the amyloid β-protein (Aβ) remains the prime therapeutic target for the treatment of Alzheimer’s disease (AD). However, rational drug design has been hampered by a lack of knowledge about neuroactive Aβ. To help address this deficit, we developed live-cell imaging of iPSC-derived human neurons (iNs) to study the effects of the most disease relevant form of Aβ-oligomeric assemblies (oAβ) extracted from AD brain. Of ten brains studied, extracts from nine caused neuritotoxicity, and in eight cases this was abrogated by Aβ immunodepletion. Here we show that activity in this bioassay agrees relatively well with disruption of hippocampal long-term potentiation, a correlate of learning and memory, and that measurement of neurotoxic oAβ can be obscured by more abundant non-toxic forms of Aβ. These findings indicate that the development of novel Aβ targeting therapeutics may benefit from unbiased activity-based discovery. To test this principle, we directly compared 5 clinical antibodies (aducanumab, bapineuzumab, BAN2401, gantenerumab, and SAR228810) together with an in-house aggregate-preferring antibody (1C22) and established relative EC50s in protecting human neurons from human Aβ. The results yielded objective numerical data on the potency of each antibody in neutralizing human oAβ neuritotoxicity. Their relative efficacies in this morphological assay were paralleled by their functional ability to rescue oAβ-induced inhibition of hippocampal synaptic plasticity. This novel paradigm provides an unbiased, all-human system for selecting candidate antibodies for advancement to human immunotherapy.
Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations
Authors: Marian Oana C. , Teo Jonathan D. , Lee Jun Yup , Song Huitong , Kwok John B. , Landin-Romero Ramon , Halliday Glenda , Don Anthony S. 
Published: March 2023

AbstractHeterozygous mutations in the GRN gene and hexanucleotide repeat expansions in C9orf72 are the two most common genetic causes of Frontotemporal Dementia (FTD) with TDP-43 protein inclusions. The triggers for neurodegeneration in FTD with GRN (FTD-GRN) or C9orf72 (FTD-C9orf72) gene abnormalities are unknown, although evidence from mouse and cell culture models suggests that GRN mutations disrupt lysosomal lipid catabolism. To determine how brain lipid metabolism is affected in familial FTD with TDP-43 inclusions, and how this is related to myelin and lysosomal markers, we undertook comprehensive lipidomic analysis, enzyme activity assays, and western blotting on grey and white matter samples from the heavily-affected frontal lobe and less-affected parietal lobe of FTD-GRN cases, FTD-C9orf72 cases, and age-matched neurologically-normal controls. Substantial loss of myelin-enriched sphingolipids (sulfatide, galactosylceramide, sphingomyelin) and myelin proteins was observed in frontal white matter of FTD-GRN cases. A less-pronounced, yet statistically significant, loss of sphingolipids was also observed in FTD-C9orf72. FTD-GRN was distinguished from FTD-C9orf72 and control cases by increased acylcarnitines in frontal grey matter and marked accumulation of cholesterol esters in both frontal and parietal white matter, indicative of myelin break-down. Both FTD-GRN and FTD-C9orf72 cases showed significantly increased lysosomal and phagocytic protein markers, however galactocerebrosidase activity, required for lysosomal catabolism of galactosylceramide and sulfatide, was selectively increased in FTD-GRN. We conclude that both C9orf72 and GRN mutations are associated with disrupted lysosomal homeostasis and white matter lipid loss, but GRN mutations cause a more pronounced disruption to myelin lipid metabolism. Our findings support the hypothesis that hyperactive myelin lipid catabolism is a driver of gliosis and neurodegeneration in FTD-GRN. Since FTD-GRN is associated with white matter hyperintensities by MRI, our data provides important biochemical evidence supporting the use of MRI measures of white matter integrity in the diagnosis and management of FTD.
Clinicopathological and molecular characterization of a case classified by DNA‑methylation profiling as “CNS embryonal tumor with BRD4–LEUTX fusion”
Authors: Lebrun Laetitia , Allard-Demoustiez Sacha , Gilis Nathalie , Van Campenhout Claude , Rodesch Marine , Roman Celine , Calò Pierluigi , Lolli Valentina , David Philippe , Fricx Christophe , De Witte Olivier , Escande Fabienne , Maurage Claude-Alain , Salmon Isabelle 
Published: March 2023

AbstractCentral Nervous System (CNS) embryonal tumors represent a heterogeneous group of highly aggressive tumors occurring preferentially in children but also described in adolescents and adults. In 2021, the CNS World Health Organization (WHO) classification drastically changed the diagnosis of the other CNS embryonal tumors including new histo-molecular tumor types. Here, we report a pediatric case of a novel tumor type among the other CNS embryonal tumors classified within the methylation class “CNS Embryonal Tumor with BRD4–LEUTX Fusion”. The patient was a 4-year girl with no previous history of disease. For a few weeks, she suffered from headaches, vomiting and mild fever associated with increasing asthenia and loss of weight leading to a global deterioration of health. MRI brain examination revealed a large, grossly well-circumscribed tumoral mass lesion located in the left parietal lobe, contralateral hydrocephalus and midline shift. Microscopic examination showed a highly cellular tumor with a polymorphic aspect. The majority of the tumor harbored neuroectodermal features composed of small cells with scant cytoplasm and hyperchromatic nuclei associated with small “medulloblastoma-like” cells characterized by syncytial arrangement and focally a streaming pattern. Tumor cells were diffusely positive for Synaptophysin, CD56, INI1 and SMARCA4 associated with negativity for GFAP, OLIG-2, EMA, BCOR, LIN28A and MIC-2. Additional IHC features included p53 protein expression in more than 10% of the tumor’s cells and very interestingly, loss of H3K27me3 expression. The Heidelberg DNA-methylation classifier classified this case as “CNS Embryonal Tumor with BRD4:LEUTX Fusion”. RNA-sequencing analyses confirmed the BRD4 (exon 13)–LEUTX (exon 2) fusion with no other molecular alterations found by DNA sequencing. Our case report confirmed that a new subgroup of CNS embryonal tumor with high aggressive potential, loss of H3K27me3 protein expression, BRDA4–LEUTX fusion, named “Embryonal CNS tumor with BRD4–LEUTX fusion”, has to be considered into the new CNS WHO classification.
Dissociative experiences of adolescents with borderline personality disorder: description and prediction
Authors: Zanarini Mary C. , Martinho Eduardo , Temes Christina M. , Glass Isabel V. , Aguirre Blaise A. , Goodman Marianne , Fitzmaurice Garrett M. 
Published: March 2023

Abstract
Aims
The first purpose of this study was to assess the severity of dissociative experiences reported by adolescent inpatients with borderline personality disorder (BPD). The second purpose was to compare the severity of their dissociative symptoms to those reported by a sample of adult inpatients with BPD. The third purpose of this study was to assess a range of clinically meaningful predictors of the severity of dissociation in adolescents and adults with BPD.

Methods
The Dissociative Experiences Scale (DES) was administered to a total of 89 hospitalized girls and boys aged 13–17 with BPD and 290 adult inpatients with BPD. Predictors of the severity of dissociation in adolescents and adults with BPD were assessed using the Revised Childhood Experiences Questionnaire (a semi-structured interview), the NEO, and the SCID I.

Results
Borderline adolescents and adults had non-significant differences on their overall DES scores and subscale scores. They also had a non-significant distribution of low, moderate, and high scores. In terms of multivariate predictors, neither temperament nor childhood adversity was a significant predictor of the severity of dissociative symptoms in adolescents. However, co-occurring eating disorders were found in multivariate analyses to be the only bivariate predictor to significantly predict this outcome. In adults with BPD, however, both the severity of childhood sexual abuse and co-occurring PTSD were significantly related to the severity of dissociative symptoms in multivariate analyses.

Conclusions
Taken together, the results of this study suggest that the severity of dissociation is not significantly different in adolescents and adults with BPD. However, the etiological factors differ substantially.
When the digital twin meets the preventive conservation of movable wooden artifacts
Authors: Wang Puxiang , Ma Xueyi , Fei Lihua , Zhang Hongye , Zhao Dong , Zhao Jian 
Published: March 2023

Abstract
To achieve sustainable heritage conservation, preventive conservation has gradually taken precedence over curative conservation, because it can inhibit the damage caused by various environmental factors and maximizes the preservation life of the artifacts. Due to susceptibility to environmental factors, preventive conservation has been used in the conservation of movable wooden artifacts to further protect them. Recently, digital twin technology, as a concept that transcends reality, can be mapped in virtual space to reflect the full lifecycle process of the corresponding entity, which is a superior characteristic that makes it valued and researched for health monitoring and health management of heritages. This paper proposes a health management method mainly for preventive conservation of movable wooden artifacts, integrating digital twin technology into the health management process. Using the Quanzhou Ship as a typical representative, several important components of health management are specifically analyzed, such as the five-dimensional model of the digital twin, the data interaction process of the digital twin, and the identification and assessment of risks. In particular, the process of preventive conservation of the stern based on the digital twin is presented in detail. This method provides a basis for future preventive conservation of movable wooden artifacts and has implications for the use of digital twin technology in the field of heritage conservation, especially for movable wooden artifacts.
Combination of terrestrial laser scanning and UAV photogrammetry for 3D modelling and degradation assessment of heritage building based on a lighting analysis: case study—St. Adalbert Church in Gdansk, Poland
Authors: Tysiac Pawel , Sieńska Anna , Tarnowska Marta , Kedziorski Piotr , Jagoda Marcin 
Published: March 2023

Abstract
The construction of the St. Adalbert Church in Gdansk dates to 1310. It is a church of rich history and great historical value, and its care is challenging. In this study, the combination of unmanned aerial vehicle (UAV) photogrammetry and terrestrial laser scanning (TLS) was used to accurately build a 3D model of the church. Together with the collected historical inventory documentation, the historic building information model (HBIM) was generated. The Autodesk-Revit® tool was used for this purpose. On the basis of the generated model, the reflection properties of the laser scanner beam and red–green–blue (RGB) images, a methodology was proposed for analysing the degradation of the church’s components. The main hypothesis of this study is based on the analysis of sunlight outside the church. In addition to the importance of the method for determining the risks of church degradation, a high-quality method for model visualization combining two photogrammetric techniques (TLS + UAV) is presented.
Visitor’s experience evaluation of applied projection mapping technology at cultural heritage and tourism sites: the case of China Tangcheng
Authors: Li Hengyi , Ito Hiromu 
Published: March 2023

Abstract
Research on digital cultural heritage is concerned with the implementation of projection mapping (PJM) technologies, projection viewing, and interactive programs at cultural heritage sites. As PJM technology has come to play an increasingly important role in attracting visitors to museums, heritage pavilions and heritage sites, the topics of digital cultural heritage and digital cultural tourism have become widely discussed in professional and academic circles. However, questions have begun to emerge over the past decade about the relevance of the content presented using PJM at heritage sites and tourist attractions to the sites’ cultural value, and various researchers have attempted to evaluate the effectiveness of PJM on the visitor experience and generate proposals for improvement. Unfortunately, the usefulness of these attempts has been limited by several methodological shortcomings. Therefore, this study proposes an original system for evaluating visitor’s cultural experiences. By evaluating the effectiveness of PJM on visitor’s cultural experiences, a methodology and a set of guidelines for applying PJM that promotes cultural understanding were proposed, and further to achieve an integrated understanding of visitor’s tendency to recall PJM information. Furthermore, a trial run of the system was conducted by the authors in a study of a digital media campaign in October 2021 and the data derived from this investigation are presented in this article as a reference point for comparable cultural heritage and tourism sites.

Graphical Abstract