bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract LB346: Mapping of shared tumor antigen reactivity with nanoparticle encapsulated mRNA in prostate cancer patients
Authors: Montauti Elena , Haabeth Ole , Rae Chris , Deutsch Samuel , Fong Lawrence , Oh David 
Published: April 2023

Abstract
Background: Prostate cancer (PC) remains refractory immune checkpoint therapies (CPT) despite having an FDA-approved cancer vaccine. PC is known to have a low mutation burden resulting in low level of neoantigens, so shared tumor associated antigens (TAAs) and translocations presumably represent a dominant source of antigens in this disease. While PC is thought to be a poorly immunogenic tumor, the frequency and breadth of tumor antigen reactivity in PC patients is unclear.
Methods: We utilized novel programmable immunogenic mRNA nanoparticle platform and created formulations encoding a range of full-length prostate TAAs (TAAmRNA) to systemically study T cell immune responses to across a range of TAAs in PC patients. We administered 8 PC TAAmRNAs (NY-ESO-1, HK2, STEAP1, TMPRSS2-ERG, PAP, PSA, PSCA and PSMA) to in-vitro cultured peripheral blood mononuclear cells (PBMC) from 43 treatment-naïve localized PC patients compared to 17 age-matched non-cancer control patients. We assessed upregulation of early T cell activation markers and interferon-gamma (INFg) cytokine production through flow cytometry and ELISPOT, respectively.
Results: 20% of PC patients possessed TAA-specific CD8+ T cell responses to at least one antigen. NY-ESO-1, HK2 and TMPRSS2-ERG had the highest T cell recall responses at an average of 35%, with NY-ESO-1 demonstrating the strongest responses per patient. Of the patients that respond to any given TAA, 47% of patients responded to three or more antigens, with 11% of PC patients responding to all TAAs. PC patients also showed heightened production of IFNg, with 35% of patients showing pan-responsiveness to three or more antigens. Particularly, HK2 stimulated the highest levels of INFg production. These levels of responsiveness are not seen in the control cohort.
Conclusions: Encapsulated mRNA nanoparticles can be used to systematically map antigen reactivity across a cohort of cancer patients and reveal frequent pan-responsiveness to multiple TAAs in what has considered to be an immunologically cold cancer These results also reveal a hierarchy in immunogenicity of candidates that can enable future vaccine development. Continual efforts to assess the immunogenicity of shared PC TAAs in more advanced disease, and how patient responses to TAAs are modulated by immunotherapies, can aid in refining combinatorial therapies for PC.
Citation Format: Elena Montauti, Ole Haabeth, Chris Rae, Samuel Deutsch, Lawrence Fong, David Oh. Mapping of shared tumor antigen reactivity with nanoparticle encapsulated mRNA in prostate cancer patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr LB346.
Abstract LB353: The switch from cap-dependent to cap-independent translation reshapes the immunopeptidome of lung cancer
Authors: Ali Anika N. , Weeden Andrew D. , Jaeger Alex M. 
Published: April 2023

Abstract
Cancer immunosurveillance relies on the presentation of peptide antigens on human leuckocyte antigen class I (HLA-I). HLA-I molecules present a diverse array of antigens, known as the “immunopeptidome”, which are recognized by cytotoxic CD8+ T cells. Recent evidence suggests that cryptic peptide antigens derived from non-canonical open reading frames (nuORFs) contribute to the immunopeptidome and drive CD8+ T cell responses. Integrating ribosome profiling (Ribo-seq) with mass spectrometry (MS) analyses has enabled the identification of several cryptic peptides derived from nuORFs including from putative non-coding regions including the 5’UTR, 3’UTR, long non coding RNAs (lncRNAs) and retained introns. Notably, many nuORFs undergo cap-independent translation. Various physiological and pharmacological stressors arrest canonical cap-dependent translation initiation and induce cap-independent translation. However, how this shift in translational dynamics influences the immunopeptidome is unknown. Using lung cancer cell lines, we show that the eIF4A inhibitor silvestrol induces cap-independent translation and reshapes the landscape of nuORF-derived peptide antigens. Silvestrol induced changes in the immunopeptidome strongly contrast with the global translation inhibitor homoharringtonine, which dampens antigen presentation. These observations suggest that the presentation of nuORF antigens in lung cancer is dynamic and tightly controlled by translational dynamics. More broadly, our study provokes reconsideration of translation inhibitors as immunomodulatory drugs that can change the HLA-I antigen repertoire and generate peptides that can act as new targets for cancer immunotherapy.
Citation Format: Anika N. Ali, Andrew D. Weeden, Alex M. Jaeger. The switch from cap-dependent to cap-independent translation reshapes the immunopeptidome of lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr LB353.
Asbest und andere gefährliche faserige Mineralien: Potenzielle Expositionswege und damit verbundene Gesundheitsrisiken
Authors: Berry Terri-Ann , Belluso Elena , Vigliaturo Ruggero , Gieré Reto , Emmett Edward A. , Testa Joseph R. , Steinhorn Gregor , Wallis Shannon L. 
Published: April 2023

Zusammenfassung
Es gibt 6 Arten länglicher Mineralpartikel (EMP), die bestimmten dimensionalen und morphologischen Kriterien entsprechen und als Asbest bekannt sind. Da Asbest für Gesundheitsprobleme wie die Asbestose und das maligne Mesotheliom verantwortlich ist, wurde er gut erforscht. Trotzdem kommt es weltweit weiterhin zu einer erheblichen Exposition, die möglicherweise 125 Millionen Menschen am Arbeitsplatz betrifft und jährlich Tausende von Todesfällen durch Exposition in Haushalten verursacht. Es gibt jedoch andere EMP, wie z.B. faserigen/asbestiformen Erionit, die als Karzinogene eingestuft sind und in Gebieten, in denen sie in lokale Baumaterialien eingebaut oder durch Erdbewegungen in die Umwelt freigesetzt wurden, mit Krebs in Verbindung gebracht wurden. Erionit ist ein stärkeres Karzinogen als Asbest, da es aber selten für kommerzielle Zwecke verwendet wird, wurden die Expositionswege weniger gut untersucht. Trotz der offensichtlichen Ähnlichkeiten zwischen Asbest und faserigem Erionit unterscheiden sich ihre Gesundheitsrisiken und Expositionspfade erheblich. Dieser Artikel untersucht die Gefahren, die von EMP ausgehen, mit besonderem Schwerpunkt auf Erionitfasern. Er umfasst eine Diskussion der globalen Standorte von Erionit und ähnlichen gefährlichen Mineralien, einen Vergleich der vielfältigen Expositionspfade für Asbest und faserigen Erionit, eine kurze Diskussion der verwirrenden Nomenklatur im Zusammenhang mit EMP und Überlegungen zur Zunahme globaler Mesotheliomfälle.
Degrowth, Air Travel, and Global Environmental Governance: Scaffolding a Multilateral Agreement for a Smaller and More Sustainable Aviation Sector
Authors: Katz-Rosene Ryan , Ambe-Uva Terhemba 
Published: April 2023

Abstract
In recent years, a growing body of literature on degrowth has compellingly identified limitations involved in decoupling economic growth from its environmental impacts. Despite this, the institutions governing the global environment continue to pursue “green growth” principles. In this article, we showcase how global environmental governance might differ if the degrowth critique were taken more seriously. We use the United Nations–based Carbon Offsetting and Reduction Scheme for International Aviation (CORSIA) to illustrate how a multilateral environmental agreement (MEA) might differ if its foundational premises were centered on degrowth as opposed to green growth. To do this, we develop a conceptual scaffold to support the construction of a degrowth-centered MEA on sustainable global aviation. While a degrowth alternative to CORSIA is admittedly unlikely given contemporary capitalist norms in global environmental governance, our proposed scaffold nevertheless adds to the growing body of work envisioning alternative scenarios for a just and sustainable postgrowth future.
AIBL-CIS de Ricci no. 2
Authors: Moore James D. , Gorea Maria 
Published: April 2023

Abstract
This article presents a previously unknown Jewish and Aramaic religious literary composition dating between the early second and early fourth centuries CE. The document focuses on a righteous man within the context of angels, demons, and spirits. The manuscript, which is housed in the Académie des Inscriptions et Belles-Lettres, Cabinet du Corpus Inscriptionum Semiticarum, has a clear acquisition history and comes from Egypt. The text is edited, translated, and provided with a philological commentary. Discussion of the text’s content is briefly brought into dialogue with the Dead Sea Scrolls and early Jewish texts.
The ‘Logics’ of Public Diplomacy: In Search of What Unites a Multidisciplinary Research Field
Authors: Pamment James , Fjällhed Alicia , Smedberg Martina 
Published: April 2023

Summary
A decade ago, Matt Armstrong noted that the War on Terror set the scene for US public diplomacy (PD) to be heavily focused on security. Other countries have focused their PD on image promotion, relationship-building or cultural relations. As digital media practices have slowly been adopted by the majority of foreign ministries, the logics governing social and digital media have also been increasingly internalised into diplomatic practice. Lacking in current PD research is a theory of the ‘logics’ that drive and motivate public diplomacy. This article explores the application of ‘PD logics’ as a theoretical framework for interpreting the ways in which foreign policy priorities, such as securitisation, trade promotion and strategic partnerships, shape PD practices. With a particular focus on the most recent wave of social and digital media adoption practices, this article establishes a theory of ‘PD logics’ that could provide new avenues for developing theories of public diplomacy.
A Critical Reflection on Chinese Masculinity: Are Chinese Men in Modern Hong Kong and Taiwan the Same?
Authors: Yau Hoi Yan 
Published: April 2023

Abstract
This paper offers a critical review of the study of masculinity among overseas Chinese. Rather than turning to Confucianism which has been deployed as the “deep structure” for explaining Chinese masculinity, this paper argues that attention should be directed to the Chinese kinship ideology, which will prove to be a more helpful tool in conceptualizing Chinese masculinity. Through ethnographic cases in Taiwan and Hong Kong, I will show how Chinese masculinity has derived from the Chinese kinship system, on the one hand, and how men in Taiwan and Hong Kong ended up expressing Chinese masculinity differently because of the different geopolitics on the other. This paper concludes that the nature and character of Chinese masculinity overseas, after all, hinges upon another two contexts: geopolitics and its relationship with femininity. It follows that Chinese masculinity cannot be studied in isolation but must be considered in relation to contexts.
Evaluation of Naples Score for Long-Term Mortality in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Authors: Şaylık Faysal , Çınar Tufan , Selçuk Murat , Akbulut Tayyar , Hayıroğlu Mert İlker , Tanboğa İbrahim Halil 
Published: April 2023

The Naples score (NS), which is a composite of cardiovascular adverse event predictors including neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, albumin, and total cholesterol, has emerged as a prognostic risk score in cancer patients. We aimed to investigate the predictive value of NS for long-term mortality in ST-segment elevation myocardial infarction patients (STEMI). A total of 1889 STEMI patients were enrolled in this study. The median duration of the study was 43 months (IQR: 32–78). Patients were divided into 2 groups according to NS as group 1 and group 2. We created 3 models as a baseline model, model 1 (baseline + NS in continuous), and model 2 (baseline + NS as categorical). Group 2 patients had higher long-term mortality rates than group 1 patients. The NS was independently associated with long-term mortality and adding NS to a baseline model improved the model performance for prediction and discrimination of long-term mortality. Decision curve analysis demonstrated that model 1 had a better net benefit probability for detecting mortality compared with the baseline model. NS had the highest contributive significant effect in the prediction model. An easily accessible and calculable NS might be used for risk stratification of long-term mortality in STEMI patients undergoing primary percutaneous coronary intervention.
A rare simultaneous presentation of combined occlusion and optic neuritis in a lupus erythematosus patient with anti-phospholipid antibody syndrome
Authors: Prakash Sarvesswaran , Gunderia Akruti Mayur , Khadar Syed Mohideen Abdul 
Published: April 2023

Background A known case of Systemic Lupus Erythematosus (SLE) developed sudden loss of vision (no light perception) with relative afferent pupillary defect in her right eye (RE) and fundus examination revealed cherry red spot over tomato splash background with tortuous and dilated veins suggestive of combined central retinal arterial and vein occlusion. Analysis Left eye (LE) had 6/6 vision but posterior segment revealed a hyperemic disc. Fundus fluorescein angiography (FFA) revealed delayed arm to retina time and increased arterial to vein transit time in RE. LE showed pooling of dye around optic disc suggestive of SLE related Optic neuritis. Patient was re-evaluated and she tested positive for Lupus anticoagulant. Patient was diagnosed to have anti-phospholipid antibody syndrome (APS) occurring secondary to SLE. She was started on intra venous steroids, anti-coagulants and disease progression in left eye was controlled. Results We report a rare simultaneous presentation of complete combined occlusion of central retinal artery and vein (CCRAVO) in RE and Optic neuritis in LE which has not been reported in literature so far. Conclusion Ocular involvement may precede other systemic symptoms in SLE, so ophthalmologist should know about this rare simultaneous presentation. Ocular activity can correlate with systemic disease activity and starting early effective treatment can prevent other systemic lesion and can be life saving.
Critical Evaluation of Drug Promotional Literature Using WHO Ethical Criteria and Perception of Clinicians at a Tertiary Care Hospital
Authors: Kaur Amanjot , Singla Shweta , Kaur Mandeep , Singh Jasninder 
Published: April 2023

Objective To evaluate the rationality of drug promotional literature (DPL) using World Health Organization (WHO) ethical criteria and to evaluate the perception of clinicians regarding DPLs using prevalidated criteria. Methods The promotional material was collected at a tertiary care teaching hospital over a period of 3 months. The perception of different prescribers has been changed. The data were analyzed using descriptive analysis. Results 191 DPLs were collected from various outpatient departments at a tertiary care hospital. The information regarding brand name, generic name, and active ingredients was mentioned in 100% of the collected material. Therapeutic uses of the promotional agents were mentioned in only 60.20%; references were cited in only 15.18%. The adverse effects were listed in only 17.80% of the DPLs. The perception regarding DPLs was gathered from 27 physicians at the same institute. The percentage of clinicians who were aware of the WHO criteria used for analyzing DPL was only 37.03%. All healthcare workers have agreed on the necessity of including critical appraisal of the DPLs in the undergraduate curriculum.
High peak inspiratory pressure may be associated with intraoperative coughing during neurosurgery under general anesthesia without neuromuscular blockade: a retrospective study
Authors: Oh Hyongmin , Sohn Jin Young , Ma Seoyoung , Choi Seungeun , Kim Yoon Jung , Lee Hyung-Chul , Lee Chang-Hyun , Kim Chi Heon , Chung Chun Kee , Park Hee-Pyoung 
Published: April 2023

Abstract
Background
The endotracheal cuff pressure depends on the airway pressure during positive-pressure ventilation. A high endotracheal cuff pressure may be related to intraoperative coughing, which can be detrimental during neurosurgery. We investigated the incidence of intraoperative coughing and its association with peak inspiratory pressure (PIP) during neurosurgery under general anesthesia without neuromuscular blockade.

Methods
This retrospective study divided 1656 neurosurgical patients who underwent total intravenous anesthesia without additional neuromuscular blockade after tracheal intubation into high (PIP > 21.6 cmH2O, n = 318) and low (PIP ≤ 21.6 cmH2O, n = 1338) PIP groups. After propensity score matching, 206 patients were selected in each group. Demographic, preoperative, surgical, and anesthetic data were collected retrospectively from electronic medical records and continuous ventilator, infusion pump, and bispectral index data from a data registry.

Results
Intraoperative coughing occurred in 30 (1.8%) patients, including 9 (0.5%) during the main surgical procedure. Intraoperative coughing was more frequent in the high PIP group than in the low PIP group before (14/318 [4.4%] vs. 16/1338 [1.2%], P < 0.001) and after (13/206 [6.3%] vs. 1/206 [0.5%], P = 0.003) propensity score matching. In multivariable logistic regression analysis after propensity score matching, a high PIP (odds ratio [95% confidence interval] 14.22 [1.81-111.73], P = 0.012), tidal volume divided by predicted body weight (mL/kg, 1.36 [1.09–1.69], P = 0.006), and surgical duration (min, 1.01 [1.00–1.01], P = 0.025) predicted intraoperative coughing.

Conclusion
The incidence of intraoperative coughing was 1.8% in neurosurgical patients undergoing general anesthesia without neuromuscular blockade and might be associated with a high PIP.
A smartphone application as a personalized treatment tool for adolescents with overweight: an explorative qualitative study
Authors: Desmet Maurane , Franssen Sieske , Varol Tugce , Fillon Alicia , Thivel David , Roefs Anne , Braet Caroline 
Published: April 2023

Abstract
Background
The present study is the first step of a 3-year European project in which a tailored smartphone application will be developed and tested as a potential tool in the personalized treatment of children and adolescents with overweight.

Methods
In this study, 10 focus groups (n = 48 participants) were conducted in Belgium, The Netherlands and France with adolescents with overweight (12–16 years; n = 30) and parents of adolescents with overweight (n = 18) to investigate their perceptions on (un)healthy behavior, the drivers of these behaviors, and the needs of an eHealth application for weight loss. A thorough thematic analysis was performed using Nvivo12.

Results
Results show that adolescents with overweight have a well-articulated perspective on (un)healthy behavior and their needs. Parents underestimate their own influence on the (un)healthy behavior of their children and report difficulties in healthy lifestyle parenting, which makes their role as a coach rather ambiguous. Concerning the needs of an eHealth application, both parents and adolescents formulated some challenging expectations regarding the content and the format including information, a monitoring feature and features that increase participants’ motivation to behave healthy. The results of this analysis will form the basis for designing a personalized eHealth application, which will be tested in a next phase.

Conclusion
We can conclude that adolescents have a well-articulated perspective on healthy and unhealthy behavior and their needs, whereby a new app could be of great help. It could function as a day-by-day diary and as a supportive coach.
Laparoscopic proximal gastrectomy with right-sided overlap and single-flap valvuloplasty (ROSF): a case-series study
Authors: Peng Wei , Yan Shangcheng , Huang Yikai , Cheng Ming , Liu Tianhua , Ren Rui , Chen Qiang , Zhang Jingyu , Gong Wei , Xing Chungen , Wu Yongyou 
Published: April 2023

Abstract
Background
There is no standard reconstruction method following proximal gastrectomy, of which gastroesophageal reflux and anastomotic complications are of great concern. Though several techniques have been devised to overcome these postoperative complications, such as double tract reconstruction, double-flap technique and side overlap fundoplication by Yamashita, none of them is considered a perfect solution. Herein, we designed a novel method of esophagogastrostomy after laparoscopic proximal gastrectomy (LPG), named right-sided overlap and single-flap valvuloplasty (ROSF).

Methods
Between March 2021 and December 2021, 20 consecutive patients underwent LPG-ROSF at Department of Gastrointestinal Surgery, Second Affiliated Hospital of Soochow University. Surgical outcomes and postoperative complications were recorded. All patients were followed-up until December 2022. Endoscopy and assessment of gastrointestinal symptoms were performed 1 year after surgery. Nutrition-related parameters including total body weight, hemoglobin, lymphocyte count, serum total protein, serum albumin and serum prealbumin were evaluated 1 year after surgery and compared with those before surgery.

Results
The mean surgery time and anastomosis time was 285.3 ± 71.3 and 61.3 ± 11.2 min respectively. None of the patients had gastrointestinal early postoperative complications. Symptomatic reflux was observed in one patient (5%) while reflux esophagitis (Los Angeles Grade A) was observed in another patient (5%). Four patients (20%) had mild dysphagia (Visick score = II) but none of them had anastomotic stenosis. There were no significant changes in nutritional status postoperatively.

Conclusions
ROSF can be safely performed after LPG and has satisfactory outcomes in preventing reflux and stenosis, and maintaining nutritional status. This technique requires further validation.