bluuebunny/crossref_metadata_2025_split huggingface dataset:
PRÓLOGO. Análisis de la desinformación: estrategias (en) de los desórdenes informativos
Authors: RENEDO FARPÓN CRISTINA , García Ull Francisco José 
Published: January 2023

La irrupción del término desinformación en los debates públicos y en las agendas política y mediática ha limitado su definición. Con frecuencia, el término fake news ha monopolizado el enfoque del problema reduciendo su complejidad a un mero producto informativo. Sin embargo, esta visión reduccionista ha sido superada por otras más abiertas donde se identifica el problema como proceso (desorden informativo) (Wardle y Derakhshanm, 2018) y no como un mero resultado (fake news).
Las consecuencias provocadas por esta desinformación afectan al buen desarrollo de entornos democráticos y a la toma de decisiones ciudadanas con la posibilidad de generar consecuencias adversas (Lewandowsky, Ecker y Cook, 2017). Por ello, es preciso analizar la desinformación dentro de su ecosistema identificando su tipología e intencionalidades, los promotores y responsables, su representación en distintos formatos y los efectos y las posibles soluciones. Todo ello en el contexto de la Sociedad de la Información en la que nos encontramos. También es necesario ampliar los enfoques y las prácticas de investigación desde miradas más cualitativas y abiertas.
Petroleum++: Listening to Our Members
Authors: Kamal Medhat M. 
Published: January 2023

As we return to a full schedule of meetings in person and I get a chance to visit with a large number of our members and discuss the various services and programs SPE offers, it became clear that more communication is needed to make all of us aware of the benefits and value of SPE membership. I plan to describe these services in detail and discuss developments in the SPE Strategic Plan, this month and in future columns.
Let me start with mentioning two services of interest to all members. For more than a year now, the SPE Board of Directors has communicated the highlights and major decisions of its quarterly meetings with all the Society’s section chairs and asked them to share the information with the membership at-large at section meetings and newsletters. Probably, a more direct method of sharing this material is needed. The information from the most recent Board of Directors meeting (October 2022 in Houston) and highlights from all 2022 meetings are posted here. Information from future meetings will be posted regularly after each meeting. This practice is important to share the work and decisions the Board is continually making with our members, and it offers an invitation for them to provide any feedback they may consider helpful to continue advancing the mission of our Society.
The other point I’d like to mention is that despite the financial challenges we have experienced recently, the contribution of our members to the technical content has never decreased. The number of papers presented at our conferences continued at the same pace. A good example is that during the month of October 2022, a total of 1,382 papers were presented at six SPE events in North America, the Middle East, and Asia Pacific. Attendance at technical sessions at SPE-managed conferences are continuously increasing to reach the pre-pandemic levels. I recently participated in the SPE Middle East Artificial Lift Conference in Bahrain, ADIPEC in Abu Dhabi, and the Earth Energy and Environment (E3) Conference at Marietta College, where attendance was higher than expected.
Other programs and services available to our members will be highlighted in future columns.
Integrated Approach Determines Formation-Water Salinity
Authors: Carpenter Chris 
Published: January 2023

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This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper IPTC 22548, “Integrated Approach for Formation-Water-Salinity Determination,” by Tariq Alshaikhmubarak, SPE, and Laila Mira, SPE, Saudi Aramco, and Sherif Ghadiry, Schlumberger, et al. The paper has not been peer reviewed. Copyright 2022 International Petroleum Technology Conference. Reproduced by permission.

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In the complete paper, two methodologies are tested to achieve measurement of formation-water salinity. First, a novel dry-weight chlorine (DWCL) measurement from an advanced spectroscopy tool is used to estimate the formation salinity at the depth of investigation of the device. The second methodology uses a new downhole induction resistivity cell in the formation-tester tool. The chlorine measurement, along with the flowline-induction-resistivity measurement, helps enhance the quality of saturation evaluation for quick decision making during logging operations and acceleration of evaluation studies instead of waiting on laboratory results.

Chlorine Work Flow
The ability to quantify chlorine concentration can help derive formation salinity as a continuous curve. Because chlorine has a large capture cross section, it is possible to extract it from capture gamma ray spectra with acceptable uncertainty, but the real challenge is to split the total chlorine signal seen by the tool into formation chlorine signal and borehole contribution. The chlorine signal split is a fundamental step in this work flow, outlined in Fig. 1.
Once the chlorine concentration in the formation is obtained—expressed as DWCL—several petrophysical applications are enabled. The first is computation of water volume assuming a known formation-water salinity. The second is computation of the sodium chloride (NaCl) equivalent salinity from an independent volume of water and DWCL. Finally, one can solve for the NaCl equivalent water salinity. Equations to achieve these steps are provided in the complete paper.

Interpretation Considerations
Capture spectroscopy measurements have a shallow depth of investigation (DOI) in the range of 8–10 in., which means sensitivity to mud-filtrate invasion in the volume of rock probed by the tool. The mud-filtrate invasion is controlled by several factors, including mud overbalance, formation exposure time to mud, formation porosity and permeability, and mudcake-formation process and efficiency. These factors must be considered when using the chlorine work flow to assess the effect of the invading water-based-mud (WBM) filtrate, which normally has a different salinity than the formation water. The main effect of oil-based-mud (OBM) filtrate invasion, assuming that only the oil phase is invading the formation, is a reduction of water volume at the measurement DOI, degrading the statistical precision of the DWCL and increasing the uncertainty in the computed salinity.
Investment Slowdown in India: Role of Monetary policy, Financial Sector and Economic Uncertainty
Authors: Sahoo Pravakar , Bishnoi Ashwani 
Published: January 2023

Abstract

Investment slowdown during the post-GFC period in India has affected the growth potential and productivity-led growth in India. We study the underlying factors for investment slowdown in India at disaggregate level - private investment, private corporate investment and household sector investment - using quarterly data from 2004-05 to 2019-20. The study finds that aggregate investment gets affected by aggregate demand, fiscal-monetary policy measures, financial sector development, exchange rate and economic uncertainty. We find similar results for private investment along with other essential determinants such as public investment, cost of capital, business confidence and uncertainty. Finally, private corporate investment is found responsive to bonds market development, real exchange rate, debt service ratio, business confidence and economic uncertainty, besides the conventional variables. Thus, to counter the current investment slowdown, there is a need to develop capital markets, strengthen monetary transmission, implement appropriate fiscal policies and reduce uncertainty in the economy.
JEL Classification: E22, E52, E62, E32.
Combined Acetaminophen and L-carnosine Treatment Prevented Anxiety-like Behaviour in Chronic Constriction Injury-induced Peripheral Neuropathy
Authors: Owoyele Victor Bamidele , Bakare Ahmed Olalekan , Olaseinde Folajimi , Ochu MuhammedJelil , Yussuf Akorede , Ekebafe Favour , Treister Roi 
Published: January 2023

Abstract
Background
Emotional derangement contributes to the worsening quality of life in a patient suffering from neuropathic pain (NP). Here, we report the therapeutic beneficial effects of combined acetaminophen and L-carnosine treatment in chronic constriction injury (CCI)-induced NP and associated comorbidities in male Wistar rats.
Methods
Seven experimental groups of male wistar rats were treated with normal saline, acetaminophen or acetaminophen and L-carnosine. Tail-immersion, Elevated Zero-maze, and light/dark box were used to assess pain and anxiety-like behaviours in rats. The kidney and liver were subjected to histotoxicological assessment after twenty-one days of treatments.
Results
Thermal hyperalgesia as well as pronounced anxiety-like behaviours were evident in CCI-induced rats. Ligated Wistar showed a significant (p < 0.001) increase in time spent in the close arms and decreased time duration in open arms compared with the unligated control in zero-maze. There was a significant decrease (p > 0.05) in time duration in the lightened compartment and an increase in time duration in the dark compartment of the light and dark box in ligated rats compared with unligated rats. Treatment with acetaminophen or its combination with L-carnosine improved the anxiolytic-like comorbid and pain behaviours in ligated rats. Combined acetaminophen and L-carnosine therapy prevented hepato-and-nephrotoxicity that is characterized in rats treated with acetaminophen alone.
Conclusion
Hence, combined acetaminophen and L-carnosine treatment is a potential treatment for CCI pain and its comorbidities.
Evaluation of the clinical efficacy of oxycodone PCIA in patients with postherpetic neuralgia complicated with breakthrough pain: protocol for a prospective, double-blind, randomized controlled trial
Authors: Yin QingHua , Zou TianHao , Sun ShuJun , Yang Dong 
Published: January 2023

Abstract
Background: Postherpetic neuralgia (PHN) is pain that persists for 1 month or more after the shingles rash has healed, the incidence of which increases with age. Some patients with PHN will experience breakthrough pain (BTP), which is unpredictable and severe in intensity, and seriously affects patients' life quality and treatment compliance. The current clinical rescue programs are lagging behind and the effect is poor. Therefore, it has become an urgent clinical problem and research hotspot to explore timely and efficient treatment options for PHN patients with breakthrough pain. Oxycodone is widely used in the treatment of moderate to severe acute and chronic pain and cancer pain. In previous studies of cancer pain, oxycodone was found to have similar efficacy as morphine, with fewer adverse effects than morphine. The efficacy and adverse reactions of oxycodone in PHN with breakthrough pain have not been reported before. This trial intends to set up a study, using morphine as a reference, to explore the efficacy and safety of oxycodone in PHN patients with breakthrough pain, with the aim of exploring the best treatment option for patients with refractory PHN episodic pain.
Methods: This study is a prospective, double-blind, randomized controlled clinical trial involving 84 PHN patients with breakthrough pain (number of outbreaks ≥ 3 times/day, NRS score ≥ 7) hospitalized in the Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. At the onset of painful outbreaks, rescue medication such as morphine patient controlled intravenous analgesia (PCIA) and equal amount of oxycodone PCIA will be given. The change in NRS score before and after the administration of the drugs and the effective rate of pain control will be evaluated to assess the efficacy and safety of the different regimens.
Discussion: We innovatively use oxycodone PCIA for the control of PHN episode pain, in order to shorten the duration of hospitalization and accelerate the recovery of patients. We hope to contribute our wisdom to the clinical problems that the current recue treatment of PHN breakthrough pain has significant lag and poor effect.
Trial registration number ChiCTR2200065358
Iron phosphide nanocrystals for highly active and stable heterogeneous catalysis of liquid-phase hydrogenation of nitrile
Authors: Tsuda Tomohiro , Sheng Min , Ishikawa Hiroya , Yamazoe Seiji , Yamasaki Jun , Yamaguchi Sho , Mizugaki Tomoo , Mitsudome Takato 
Published: January 2023

Abstract
Iron-based heterogeneous catalysts are ideal metal catalysts owing to their abundance and low toxicity. However, conventional iron nanoparticle (Fe NP) catalysts exhibit extremely low activity for liquid-phase reactions and lack air stability. Previous attempts to encapsulate Fe NPs in shell materials toward air stability improvement were offset by the low activity of the Fe NPs. To overcome the trade-off between activity and stability in conventional Fe NP catalysts, we developed novel air-stable iron phosphide single nanocrystal (Fe2P NC) catalysts. The Fe2P NC exhibited high activity for liquid-phase nitrile hydrogenation, whereas the conventional Fe NPs demonstrated no activity. Furthermore, the air stability of the Fe2P NC allowed facile immobilization on supports; TiO2 enhanced the Fe2P NC activity. The resulting TiO2-supported Fe2P NC successfully converted various nitriles to primary amines and demonstrated high reusability. The development of air-stable and active Fe2P NC catalysts significantly expands the application scope of iron catalysts.
Quantum Simulation of Preferred Tautomeric State Prediction
Authors: Shee Yu , Yeh Tzu-Lan , Hsiao Jen-Yueh , Yang Ann , Lin Yen-Chu , Hsieh Min-Hsiu 
Published: January 2023

Abstract
Prediction of tautomers plays an essential role in computer-aided drug discovery. However, it
remains a challenging task nowadays to accurately predict the canonical tautomeric form of a given
drug-like molecule. Lack of extensive tautomer databases, most likely due to the difficulty in experimental
studies, hampers the development of effective empirical methods for tautomer predictions.
A more accurate estimation of the stable tautomeric form can be achieved by quantum chemistry
calculations. Yet, the computational cost required prevents quantum chemistry calculation as a
standard tool for tautomer prediction in computer-aided drug discovery. In this paper we propose
a hybrid quantum chemistry-quantum computation workflow to efficiently predict the dominant
tautomeric form. Specifically, we select active-space molecular orbitals based on quantum chemistry
methods. Then we utilize efficient encoding methods to map the Hamiltonian onto quantum
devices to reduce the qubit resources and circuit depth. Finally, variational quantum eigensolver
(VQE) algorithms are employed for ground state estimation where hardware-efficient ansatz circuits
are used. To demonstrate the applicability of our methodology, we perform experiments on two
tautomeric systems: acetone and Edaravone, each having 52 and 150 spin-orbitals in the STO-3G
basis set, respectively. Our numerical results show that their tautomeric state prediction agrees with
the CCSD benchmarks. Moreover, the required quantum resources are efficient: in the example of
Edaravone, we could achieve chemical accuracy with only eight qubits and 80 two-qubit gates.
Modelling Asymetries Among Consumer Price Index, Currency Price, Gross Domestic Output and Aggregate Import Demand in an Emerging Economy: The Case of Nigeria
Authors: Iormom Bruce , Usman Ojonugwa , Bature Bitrus Naka , Ogba Likita J. 
Published: January 2023

Abstract
This study investigates to determine whether the sensitivity of import demand to negative partial sum processes of consumer price index, currency price and national income merely mirror the elasticities corresponding to positive partial sums of these same determinants in Nigeria. The test of the recently developed nonlinear autoregressive distributed lag model provided strong proof for asymmetry over the short- and long-run. From the long-run non-linear Autoregressive Distributed Lag estimates, import demand was found to be positve, inelastic and significant in response to positive shocks to Consumer Price Index, and positve, significant but elastic in response to negative shocks. The short-term response of import demand to Consumer Price Index is revealed to be biased towards negative shocks. Import demand is indicated to be more responsive to currency appreciation than depreciation. Further, we found higher coefficients of income elasticity of import demand associated with negative changes in Gross Domestic Product than with positive changes. In the light of these findings, we recommend macroeconomic and microeconomic policies that can drive down domestic inflation and improve internal competitiveness.
JEL Codes: F4; F10; F13; F31
Gender is a non-negligible risk factor affecting the overall survival time of NSCLC patients: a nationwide population-based study
Authors: liang long , Wang Bingbing , Wang Changhui , Xie Shuanshuan 
Published: January 2023

Abstract
Purpose: The aim of this study is to explore the effect of gender on overall survival (OS) in non–small cell lung cancer (NSCLC) patients.
Methods: The Surveillance, Epidemiology, and End Results Database (SEER) was queried for NSCLC cases from 2004 to 2015. A total of 129,864 NSCLC patients were identified to enroll in our study, including 78,460 males and 51,404 females. We compared and analyzed the demographics, socioeconomics, regional differences, tumor characteristics, treatment, and survival time in both groups of patients.
Results: Kaplan-Meier analysis showed improved OS in the female group compared to the male group throughout all stages (P<0.001). Median OS for males were 33.00 (95%CI: 31.88-34.12), 23.00 (95%CI: 21.93-24.07), 11.00 (95%CI: 10.77-11.23), and 4.00 (95%CI: 3.90-4.10) months from stage IB to IV, respectively. Median OS for females were 52.00 (95%CI: 49.53-54.47), 30.00 (95%CI: 27.95-32.05), 13.00 (95%CI: 12.63-13.37), 5.00 (95%CI: 4.85-5.15) months respectively as counterparts. A multivariable Cox regression model was constructed and analyzed on survival for each clinical stage. Being in the female cohort could significantly reduce risks for mortality compared with male cohort at all stages (hazard ratios [HR] of 0.766, 0.797, 0.846, and 0.857 for stages IB through IV respectively, [all P< 0.001]).
Conclusions: For various stages of patients older than 45 years, the OS of female NSCLC patients with or without chemotherapy is greater than that for male counterparts. Gender is a non-negligible risk factor affecting the overall survival time of NSCLC patients.
Ganoderma Lucidum Ameliorated Depression-Like Behavior in an Unpredictable Chronic Mild Stress Rat Model Via Regulation of Monoamines
Authors: Cheng Hao Yuan 
Published: January 2023

Abstract

Purpose This study investigated antidepressant-like effect of Gl-E on rats exposed to UCMS and elucidated its potential mechanism of antidepressant action of Gl-E by detecting the levels of monoamines and their metabolites in the rats’ brains. Methods Sprague-Dawley rats were subjected to UCMS and treated with extract ofG. lucidum(Gl-E) and fluoxetine (FLU) for 28 consecutive days. The sucrose preference test (SPT) and open field test (OFT) were applied to assess the antidepressant effects. The levels of monoamines including serotonin (5-hydroxytryptamine, 5-HT), norepinephrine (NE) and dopamine (DA) and their metabolites in the brain of rats were measured by HPLC. Results The results revealed that 4 weeks of UCMS exposure induced significant depression-like behavior, with low 5-HT, NE and DA levels in the rats’ brains. The treatment of Gl-E (0.1 and 0.5 g/kg) or FLU significantly alleviated the behavior deficiency and body weight reduction in UCMS rats. In addition, the levels of 5-HT, NE and DA in the brain of UCMS rats were increased after the Gl-E treatment. Conclusion The present study demonstrated that Gl-E could ameliorate depression-like behaviors in UCMS rats. Monoamines played an important role in the antidepressant action of Gl-E.
Swarm intelligence and evolutionary algorithms on an introduced novel type of time-cost trade-off problem
Authors: Naseri Hamed , Golroo Amir , Fani Amirhossein , Gandomi Amir H. 
Published: January 2023

Abstract
Time and cost are essential criteria for analyzing project feasibility. Project managers analyze the cost and duration of projects and make trade-offs between them before project initiation. During the implementation phase of a given project, a delay exists, making the initial plan impractical. Additionally, the contractor must pay a certain amount of money as delay fine based on the contract or spends extra money in order to reduce the duration of the project. This study proposes a new method to consider a trade-off between these two alternatives as a way to minimize the total time and the total extra money that should be paid. To this end, four strategies–minimizing costs, omitting delay under a minimum budget, minimizing cost and delay of the project simultaneously, and reducing the delay up to a particular level under a minimum budget–are taken into account to help decision-makers make the best decision. A case study is presented in this work, and 13 swarm intelligence and evolutionary algorithms are applied to find optimal solutions. A new index is developed and is used to compare various strategies and different algorithms. Based on the results, the introduced approach can reduce project costs and project delays by 28.8% and 85.7%, respectively. Moreover, the cuckoo search algorithm, invasive weed optimization, coyote optimization algorithm, and differential evolutionary algorithm outperform the other algorithms based on outcomes and the Tukey pairwise comparison results. Furthermore, the firefly algorithm is recognized as being the fastest algorithm for solving a delay time-cost trade-off problem.
Effects of Pu-erh and Dian Hong tea polyphenols on the gut-liver axis in mice
Authors: Wang Ning , Lan Chaohua , Mehmood Muhammad Aamer , He Manli , Xiao Xiongjun , Li Linman , Liao Dalong , Xu Kewei , Mo Shan , Zhang Puyu , Zhou Xiaoli , Gu Baoxiang , Zhu Hui , Wu Tao 
Published: January 2023

Abstract
The relationship among microbiota, intestine, and liver is an essential factor affecting the health of the host, and diet modifies the type of gut microbes. This experimental study evaluated the chemical constituents of polyphenols in Pu-erh (PTP) and Dian Hong tea (DHTP). It also examined the co-regulatory effects of PTP and DHTP on the intestinal flora and liver tissues in mice based on the sequence analysis of 16S rRNA genes and transcriptome. The results showed that higher concentrations of EGC (epigallocatechin), C (catechin), EC (epicatechin) and EGCG (epigallocatechin gallate) were observed in DHTP, and higher contents of GA (gallic acid), ECG (epicatechin-3-gallate), TF (theaflavin) and TB (theabrownin) were found in PTP. The intake of PTP and DHTP significantly reduced the rates of weight gain in mice. Microbial community diversity was significantly higher in mice treated with PTP and DHTP than the control group. Notable, the beneficial microbes, such as Lactobacillus was significantly increased in PTP-treated mice, while Lachnospiraceae was significantly increased in DHTP -treated mice. Both PTP and DHTP improved the activity of the antioxidant enzymes (SOD) and total antioxidant capacity (T-AOC) in liver. The transcriptome analysis revealed that the positive effect of PTP and DHTP could be attributed to changes in different metabolic pathways, most related to antioxidant and lipid metabolism. This study revealed that PTP and DHTP played the benefical effects through the gut-liver axis in mice.