bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-Linear Dynamic Modeling and Analysis of Split-Torque Face-Gear Drive Systems
Authors: Aydoğan Mustafa Özgür , Sarıbay Zihni B. , Özgüven H. Nevzat 
Published: January 2023

Abstract
A non-linear dynamic model of a multi-mesh involute spur pinion-driven face-gear split-torque drive system is developed. The lumped mass model consists of five pinions and two face-gears with seven rotational degrees-of-freedom. Model includes two inputs, two outputs, and three idler gears meshing with two identical face-gears at the bottom and top of the assembly. Face-gear tooth form and corresponding spur gear teeth are established by differential geometry and the theory of gearing. Face-gear drive system mesh stiffnesses are established by utilizing finite strip method for the first time in the literature. The mesh stiffness and damping are time-variant. The model includes clearance-type non-linearity. The harmonic balance method is utilized to solve the non-linear differential equations of motion. The results are compared with the time simulation results. The stability is checked with Floquet theory and bifurcation diagrams from Poincare sections. The model is fully capable of generating the tooth geometries, mesh stiffnesses, and gear train dynamics without reliance on any package programs. Hence, the model provides flexibility and fast computation for parametric studies compared to existing literature. The effect of the pinions’ orientations on the face-gear is investigated to evaluate the mesh phasing effects among system dynamic response. The effect of sub-harmonic motion on the dynamic response of the split-torque face-gear system is also demonstrated for the first time in the literature. The case studies demonstrate that sub-harmonic resonance peaks are avoided.
Molecular Characteristics of an NDM-4 and OXA-181 Co-Producing K51-ST16 Carbapenem-Resistant Klebsiella pneumoniae: Study of Its Potential Dissemination Mediated by Conjugative Plasmids and Insertion Sequences
Authors: Zhang Feilong , Li Ziyao , Liu Xinmeng , Luo Guolan , Wu Yongli , Li Chen , Zhao Jiankang , Zhang Yulin , Hu Yanning , Lu Binghuai 
Published: January 2023

ABSTRACT

The carbapenem-resistant
Klebsiella pneumoniae
(CRKP) strain GX34 was recovered from the respiratory tract of an elderly male with severe pneumonia, and only susceptible to amikacin, tigecycline, and colistin. Complete genome suggested that it belonged to K51-ST16 and harbored plasmid-encoded NDM-4 and OXA-181, located on IncFIB plasmid GX34p1_NDM-4 and ColKP3/IncX3 plasmid GX34p4_OXA-181, respectively. A series of transconjugants generated in the plasmid conjugation assays, including
Escherichia coli
J53-N1 (harboring a self-transmissible and
bla
NDM-1
-producing plasmid Eco-N-1-p), J53-N2 (harboring a
bla
NDM-4
-producing plasmid and a helper plasmid GX34p5), and J53-O (harboring a
bla
OXA-181
-producing plasmid), could be stably inherited after 10 days of serial passage and no significant biological fitness costs were detected. Furthermore, we first reported the
bla
NDM-1
gene, derived from
bla
NDM-4
mutation (460C>A) under meropenem pressure, could be
in vitro
transferred into a self-conjugative, recombined plasmid Eco-N-1-p of J53-N1. Eco-N-1-p was mainly recombined by GX34p4_OXA-181 (40,449 bp, 75.16%) and GX34p1_NDM-4 (8,553 bp, 15.89%), in which IS
26
and IS
5-like
probably played a major role. Eco-N-1-p could be transferred into the conjugation recipient
K. pneumoniae
KP54 and make the latter sacrifice fitness. The retention rates of
bla
NDM-1
remained high stability (>80% after 200 generations). The comparative genomic analysis of GX34 and those carrying
bla
NDM-4
or
bla
OXA-181
genes retrieved from the NCBI RefSeq database showed all
bla
NDM-4
(26/26, 100.00%) and
bla
OXA-181
(13/13, 100.00%) were surrounded by IS
26
. The immediate environment of
bla
NDM-4
and
bla
OXA-181
in GX34 and some retrieved strains shared identical features, hinting at their possible dissemination. Effective measures should be taken to monitor the spread of this clone.
Supplemental Material: Inclination and heterogeneity of layered geological sequences influence dike-induced ground deformation
Authors: Clunes Matías , al. et 
Published: January 2023

<p>Extended information about the numerical model setup (text and Figures S1 and S2), a geological map for Figures 1E and 1D (Figure S3), extended results (text and Figures S4-S19) and datasets (surface displacement data in 36 Excel files and 5 COMSOL Multiphysics 5.4 files) with an explanatory text for each one. </p>
Agreement between patient’s description of abdominal symptoms of possible upper gastrointestinal cancer and general practitioner consultation notes: a qualitative analysis of video-recorded UK primary care consultation data
Authors: Hardy Victoria , Usher-Smith Juliet , Archer Stephanie , Barnes Rebecca , Lancaster John , Johnson Margaret , Thompson Matthew , Emery Jon , Singh Hardeep , Walter Fiona M 
Published: January 2023

IntroductionAbdominal symptoms are common in primary care but infrequently might be due to an upper gastrointestinal (UGI) cancer. Patients’ descriptions may differ from medical terminology used by general practitioners (GPs). This may affect how information about abdominal symptoms possibly due to an UGI cancer are documented, creating potential missed opportunities for timely investigation.ObjectivesTo explore how abdominal symptoms are communicated during primary care consultations, and identify characteristics of patients’ descriptions that underpin variation in the accuracy and completeness with which they are documented in medical records.Methods and analysisPrimary care consultation video recordings, transcripts and medical records from an existing dataset were screened for adults reporting abdominal symptoms. We conducted a qualitative content analysis to capture alignments (medical record entries matching patient verbal and non-verbal descriptions) and misalignments (symptom information omitted or differing from patient descriptions). Categories were informed by the Calgary-Cambridge guide’s ‘gathering information’ domains and patterns in descriptions explored.ResultsOur sample included 28 consultations (28 patients with 18 GPs): 10 categories of different clinical features of abdominal symptoms were discussed. The information GPs documented about these features commonly did not match what patients described, with misalignments more common than alignments (67 vs 43 instances, respectively). Misalignments often featured patients using vague descriptors, figurative speech, lengthy explanations and broad hand gestures. Alignments were characterised by patients using well-defined terms, succinct descriptions and precise gestures for symptoms with an exact location. Abdominal sensations reported as ‘pain’ were almost always documented compared with expressions of ‘discomfort’.ConclusionsAbdominal symptoms that are well defined or communicated as ‘pain’ may be more salient to GPs than those expressed vaguely or as ‘discomfort’. Variable documentation of abdominal symptoms in medical records may have implications for the development of clinical decision support systems and decisions to investigate possible UGI cancer.
Association between interrupted access to sex work community services during the COVID-19 pandemic and changes in sex workers’ occupational conditions: findings from a community-based cohort study in Vancouver, Canada
Authors: McBride Bronwyn , Shannon Kate , Pearson Jennie , Braschel Melissa , Krüsi Andrea , McDermid Jennifer , Goldenberg Shira M 
Published: January 2023

ObjectivesGlobally, criminalisation has shaped sex workers’ structural exclusion from occupational protections, and this exclusion has been exacerbated during the COVID-19 pandemic. While community organisations aim to bridge this gap through providing health and safety resources for sex workers, many were forced to scale back services when Canadian provinces declared a state of emergency at the pandemic onset. As little empirical research has examined the impacts of sex work community services interruptions amid COVID-19, our objectives were to (1) examine the correlates of interrupted access to community services and (2) model the independent association between interrupted access to community services and changes in working conditions (ie, self-reported increases in workplace violence or fear of violence), among sex workers during the COVID-19 pandemic.Design, setting and participantsAs part of an ongoing community-based cohort of sex workers in Vancouver, Canada (An Evaluation of Sex Workers Health Access, 2010–present), 183 participants completed COVID-19 questionnaires between April 2020 and April 2021.AnalysisCross-sectional analysis used bivariate and multivariable logistic regression with explanatory and confounder modelling approaches.Results18.6% of participants (n=34) reported interrupted access to community services (closure/reduction in drop-in hours, reduced access to spaces offering sex worker supports and/or reduced access/contact with outreach services). In multivariable analysis, sex workers who had difficulty maintaining social supports during COVID-19 (adjusted OR, AOR 2.29, 95% CI 0.95 to 5.56) and who experienced recent non-fatal overdose (AOR 2.71, 95% CI 0.82 to 8.98) faced marginally increased odds of service interruptions. In multivariable confounder analysis, interrupted access to community services during COVID-19 was independently associated with changes in working conditions (ie, self-reported increases in workplace violence or fear of violence; AOR 4.00, 95% CI 1.01 to 15.90).ConclusionsFindings highlight concerning implications of community service interruptions for sex workers’ labour conditions. Sustainable funding to community organisations is urgently needed to uphold sex workers’ occupational safety amid COVID-19 and beyond.
Prehabilitation in elective patients undergoing cardiac surgery: a randomised control trial (THE PrEPS TRIAL) – a study protocol
Authors: Akowuah Enoch , Mathias Ayesha , Bardgett Michelle , Harrison Samantha , Kasim Adetayo S , Loughran Kirsti , Ogundimu Emmanuel , Trevis Jason , Wagnild Janelle , Witharana Pasan , Hancock Helen C , Maier Rebecca H 
Published: January 2023

IntroductionPrehabilitation prior to surgery has been shown to reduce postoperative complications, reduce length of hospital stay and improve quality of life after cancer and limb reconstruction surgery. However, there are minimal data on the impact of prehabilitation in patients undergoing cardiac surgery, despite the fact these patients are generally older and have more comorbidities and frailty. This trial will assess the feasibility and impact of a prehabilitation intervention consisting of exercise and inspiratory muscle training on preoperative functional exercise capacity in adult patients awaiting elective cardiac surgery, and determine any impact on clinical outcomes after surgery.Methods and analysisPrEPS is a randomised controlled single-centre trial recruiting 180 participants undergoing elective cardiac surgery. Participants will be randomised in a 1:1 ratio to standard presurgical care or standard care plus a prehabilitation intervention. The primary outcome will be change in functional exercise capacity measured as change in the 6 min walk test distance from baseline. Secondary outcomes will evaluate the impact of prehabilitation on preoperative and postoperative outcomes including; respiratory function, health-related quality of life, anxiety and depression, frailty, and postoperative complications and resource use. This trial will evaluate if a prehabilitation intervention can improve preoperative physical function, inspiratory muscle function, frailty and quality of life prior to surgery in elective patients awaiting cardiac surgery, and impact postoperative outcomes.Ethics and disseminationA favourable opinion was given by the Sheffield Research Ethics Committee in 2019. Trial findings will be disseminated to patients, clinicians, commissioning groups and through peer-reviewed publication.Trial registration numberISRCTN13860094.
Comparison of drug-coated balloon with conventional balloon for angioplasty in symptomatic intracranial atherosclerotic stenosis
Authors: Tang Yao , Li Tianxiao , Liu Wenbo , He Yanyan , Zhu Liangfu , Wang Zi-Liang , He Yingkun 
Published: January 2023

BackgroundDrug-coated balloon (DCB) angioplasty has been studied for reducing the occurrence of restenosis after treatment for intracranial atherosclerotic stenosis (ICAS), but no comparison has been published of the use of drug-coated and non-coated balloons in angioplasty for ICAS. We aim to compare the safety and efficacy of DCB angioplasty with conventional balloon (CB) angioplasty for the treatment of symptomatic ICAS.MethodsOne hundred cases with symptomatic ICAS treated with DCB (n=49) and CB (n=51) angioplasty were retrospectively analyzed. 1:1 propensity score matching (PSM) was completed to eliminate bias in the patients selected for further analysis. The periprocedural events and follow-up outcomes between the two groups were compared.ResultsThere were 32 cases in each group after PSM. Technical success (<50% residual stenosis) was achieved in 30 cases (93.8%) in the DCB group and in 28 cases (87.5%) in the CB group. The rates of stroke or mortality within 30 days were 3.1% in the DCB group and 6.3% in the CB group (p=1). The incidence of restenosis in the DCB group (6.3%) was significantly lower than that in the CB group (31.3%) (p=0.01).ConclusionsCompared with CB angioplasty, DCB angioplasty can effectively reduce the incidence of restenosis. Further studies are needed to validate the role of DCB angioplasty in the management of symptomatic ICAS.
Integrated approach to improve simulation models in a deep-water heavy oil field with 4D seismic monitoring
Authors: Correia Manuel Gomes , Maleki Masoud , Mesquita da Silva Felipe Bruno , Gomes Alessandra Davolio , Schiozer Denis Jose 
Published: January 2023

The geological features revealed by well production data or 4D seismic are often neglected in data assimilation or are disconnected from the geomodelling tasks through simplifications on static and dynamic data. This work provides a workflow to accurately integrate 4D seismic insights through a forward geomodelling approach and provides prior simulation models calibrated with observed dynamic data. The methodology follows four steps: (1) develop the geological model; (2) generate equiprobable geostatistical realizations based on the multiple stochastic approach; (3) apply the discretized Latin Hypercube sampling technique combined with geostatistics realizations (DLHG) method; and (4) validate the geological consistency and uncertainty quantification using the observed dynamic data. The methodology is applied to a real turbiditic reservoir, a heavy oil field in the offshore Campos Basin, Brazil. From the 4D seismic datasets, the following data were available: (1) base survey; (2) monitor-2016; and (3) monitor-2020. The interpreted 4D seismic trends were integrated in the geological model by combining the geometrical modelling technique, for observed structural features, with the objects’ modelling approach, for the observed sand channels. The geostatistical realizations were then combined with dynamic uncertainties using the DLHG method. The quantitative validation based on the Normalized Quadratic Deviation with Signal (NQDS) indicator showed that the generated prior simulation models encompass the observed production data. In addition, the match with observed 4D seismic data based on difference of the root mean square (dRMS) amplitude maps highlighted the value of adding 4D seismic information. This paper presents a successful forward modelling approach to highlight the value of 4D seismic on the calibration of simulation models prior to data assimilation.
An Updated Meta-Analysis for Safety Evaluation of Alirocumab and Evolocumab as PCSK9 Inhibitors
Authors: Choi Hye Duck , Kim Ji Hae 
Published: January 2023

Background. Alirocumab and evolocumab, as protein convertase subtilisin kexin type 9 (PCSK9) inhibitors, have been reported to reduce cardiovascular risk. This meta-analysis is aimed at updating the safety data of PCSK9 inhibitors. Methods. We assessed the relative risk for all treatment-related adverse events, serious adverse events, diabetes-related adverse events, and neurocognitive and neurologic adverse events with PCSK9 inhibitors compared to controls (placebo or ezetimibe). In addition, we conducted a meta-analysis to quantitatively integrate and estimate the adverse event rates in long-term studies. Results. There were no significant differences between PCSK9 inhibitors and controls in the relative risk analysis. In a subgroup analysis of each PCSK9 inhibitor, alirocumab treatment significantly reduced the risk of serious adverse events compared to control treatment (

risk

ratio

RR

=
0.937

; 95% confidence interval (CI), 0.896–0.980), but no significant difference was observed with evolocumab treatment (

RR
=
1.003

; 95% CI, 0.963–1.054). Moreover, alirocumab treatment afforded a significant reduction in the risk of diabetes-related adverse events compared to control treatment (

RR
=
0.9137

; 95% CI, 0.845–0.987). The overall incidence (event rate) of long-term adverse events was 75.1% (95% CI, 71.2%–78.7%), and the incidence of serious long-term event rate was 16.2% (95% CI, 11.6%–22.3%). Conclusions. We suggest that alirocumab and evolocumab are generally safe and well tolerated and that their addition to background lipid-lowering therapy is not associated with an increased risk of adverse events or toxicity.
Continuous Positive Airway Pressure for the Treatment of Supine Hypertension and Orthostatic Hypotension in Autonomic Failure
Authors: Okamoto Luis E. , Celedonio Jorge E. , Smith Emily C. , Paranjape Sachin Y. , Black Bonnie K. , Wahba Amr , Park Jin-Woo , Shibao Cyndya A. , Diedrich André , Biaggioni Italo 
Published: January 2023

Background:
Supine hypertension affects most patients with orthostatic hypotension (OH) due to autonomic failure, but it is often untreated for fear of worsening OH. We hypothesized that increasing intrathoracic pressure with continuous positive airway pressure (CPAP) had a Valsalva-like blood-pressure-lowering effect that could be used to treat nocturnal supine hypertension in these patients, while reducing nocturnal pressure diuresis and improving daytime OH.

Methods:

In Protocol 1, we determined the acute hemodynamic effects of increasing levels of CPAP (0, 4, 8, 12, and 16 cm H
2
O, 3 minutes each) in 26 patients with autonomic failure and supine hypertension studied while awake and supine. In Protocol 2 (n=11), we compared the effects of overnight therapy with CPAP (8–12 cm H
2
O for 8 hours) versus placebo on nocturnal supine hypertension, nocturnal diuresis and daytime OH in a 2-night crossover study.

Results:

In Protocol 1, acute CPAP (4–16 cm H
2
O) decreased systolic blood pressure in a dose-dependent manner (maximal drop 22±4 mmHg with CPAP 16) due to reductions in stroke volume (−16+3%) and cardiac output (−14±3%). Systemic vascular resistance and heart rate remained unchanged. In Protocol 2, overnight CPAP lowered nighttime systolic blood pressure (maximal change −23±5 versus placebo −1±7 mmHg;
P
=0.023) and was associated with lower nighttime diuresis (609±84 versus placebo 1004±160 mL;
P
=0.004) and improved morning orthostatic tolerance (AUC
upright SBP
642±121 versus placebo 410±109 mmHg*min;
P
=0.014).

Conclusions:
CPAP is a novel nonpharmacologic approach to treat the supine hypertension of autonomic failure while improving nocturia and daytime OH.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03312556.
How reliable are unsupervised author disambiguation algorithms in the assessment of research organization performance?
Authors: Abramo Giovanni , D’Angelo Ciriaco Andrea 
Published: January 2023

Abstract
Assessing the performance of universities by output to input indicators requires knowledge of the individual researchers working within them. Although in Italy the Ministry of University and Research updates a database of university professors, in all those countries where such databases are not available, measuring research performance is a formidable task. One possibility is to trace the research personnel of institutions indirectly through their publications, using bibliographic repertories together with author names disambiguation algorithms. This work evaluates the goodness-of-fit of the Caron and van Eck, CvE unsupervised algorithm by comparing the research performance of Italian universities resulting from its application for the derivation of the universities’ research staff, with that resulting from the supervised algorithm of D’Angelo, Giuffrida, and Abramo (2011), which avails of input data. Results show that the CvE algorithm overestimates the size of the research staff of organizations by 56%. Nonetheless, the performance scores and ranks recorded in the two compared modes show a significant and high correlation. Still, nine out of 69 universities show rank deviations of two quartiles. Measuring the extent of distortions inherent in any evaluation exercises using unsupervised algorithms, can inform policymakers’ decisions on building national research staff databases, instead of settling for the unsupervised approaches.
Spatialisation of Text Worlds: Contrastive Interpretations in P.L. Travers’s Mary Poppins
Authors: Vathanalaoha Kriangkrai 
Published: January 2023

Abstract
Fictional situations recounted by a narrator instantaneously trigger a mental representation of a text world (Gavins 2007) which aims to explicate how meaning is achieved by readers based on salient theories of stylistics. This study examines how text world creation is established while reading Mary Poppins (Travers 2014). Crucial excerpts are explored to explain how readers perceive events that constitute the narrative. As the author recounts all events through an omniscient perspective, a discourse world is established through schematic data of all participants in the discourse based on common ground information. Deictic shift (Segal 1995) is employed to demonstrate how a mental representation is spatially situated and to achieve rich presentations of the fictional world. The present study concludes that text-world approaches to Mary Poppins could explain interpretive controversies between the novel and the film, since participants, schema and ontological distance trigger spatialisation of the fictional worlds.
Framing of the Unified Examination Certificate by Malaysian Ethnic Newspapers
Authors: Lam Kai Chee , Ting Yeo Wei , Ang Lay Hoon , Hoe Foo Terng 
Published: January 2023

Abstract
Media framing makes an issue salient. This study attempts to determine the frequency of episodic and thematic frames in news about the Unified Examination Certificate issue and identify the framing dimensions and valence used. Textual analysis of the content and headlines was performed on 100 news articles from newspapers of two languages. Results indicate that all the articles were framed episodically, with the “attribution of responsibility” dimension used most frequently, followed by the “human interest” and “conflict” dimensions. Chinese articles tended to use neutral valance, whereas Malay articles mostly used negative valence. These findings provide insights into ethnic politically-influenced and reader-oriented presentations of an issue by different newspapers. Future studies may focus on newspapers using the same language and investigate the framing effects by mainstream and alternative media.