bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practice and Perception of Traditional Medicine Practitioners towards Challenges Facing Traditional Medicine Practice in Nigeria: A Pilot Study
Authors: Ibrahim Jemilat Aliyu , Gegele Ibrahim Babatunde , Hamzat Omotayo Tirmidhi , Egharevba Henry Omoregie , Jegede Adeola Ibikunle , Kunle Oluyemisi Folashade , Adigwe Obi Peter 
Published: August 2023

Aim: This study explores and documents obstacles faced by Traditional Medicine Practitioners (TMPs) in Nigeria. Traditional Medicine (TM) plays a vital role in the healthcare systems of low- and middle-income countries, yet it encounters numerous challenges.
Place and Duration of Study: This study was carried out in Nigeria by the Department of Medicinal Plant Research and Traditional Medicine, National Institute for Pharmaceutical Research and Development, Idu – Abuja, Nigeria between December 2021 and January 2022.
Methodology: A survey was conducted among Nigerian TMPs using a semi-structured questionnaire to gain insights into their challenges and potential solutions. TMPs were recruited nationwide using purposive and convenient sampling, and descriptive statistics were used to present data gathered.
Results: The majority of TMP respondents (67%) were male, with 48% holding graduate degrees and 11% having doctorates. Regarding practice, 87% of TMPs maintain patient records, and 88% keep medicinal recipe records. Most TMPs (81%) engage in general practice alongside other forms. Collaboration willingness was expressed by 89% towards fellow practitioners, 95% towards research institutes, and 89% towards individual researchers. Challenges identified by TMPs include a lack of cooperation from orthodox doctors (25%), absence of standardized products (19%), inadequate policies (19%), and disorganization among TMPs (15%). Product registration revealed that 81% of TMPs had unregistered products, with 49% citing high registration costs and 21% lacking knowledge about the process. Specific challenges mentioned were insufficient financial resources (48%) and a need for training (30%).
Conclusion: It is crucial for stakeholders to collaborate and review policies to address the highlighted challenges and gaps as found in this study.
Consensus Practice Guidelines on Postdural Puncture Headache From a Multisociety, International Working Group
Authors: Uppal Vishal , Russell Robin , Sondekoppam Rakesh , Ansari Jessica , Baber Zafeer , Chen Yian , DelPizzo Kathryn , Dîrzu Dan Sebastian , Kalagara Hari , Kissoon Narayan R. , Kranz Peter G. , Leffert Lisa , Lim Grace , Lobo Clara A. , Lucas Dominique Nuala , Moka Eleni , Rodriguez Stephen E. , Sehmbi Herman , Vallejo Manuel C. , Volk Thomas , Narouze Samer 
Published: August 2023

ImportancePostdural puncture headache (PDPH) can follow unintentional dural puncture during epidural techniques or intentional dural puncture during neuraxial procedures, such as a lumbar puncture or spinal anesthesia. Evidence-based guidance on the prevention, diagnosis, and management of this condition is, however, currently lacking.ObjectiveTo fill the practice guidelines void and provide comprehensive information and patient-centric recommendations for preventing, diagnosing, and managing PDPH.Evidence ReviewWith input from committee members and stakeholders of 6 participating professional societies, 10 review questions that were deemed important for the prevention, diagnosis, and management of PDPH were developed. A literature search for each question was performed in MEDLINE on March 2, 2022. Additional relevant clinical trials, systematic reviews, and research studies published through March 2022 were also considered for practice guideline development and shared with collaborator groups. Each group submitted a structured narrative review along with recommendations that were rated according to the US Preventive Services Task Force grading of evidence. Collaborators were asked to vote anonymously on each recommendation using 2 rounds of a modified Delphi approach.FindingsAfter 2 rounds of electronic voting by a 21-member multidisciplinary collaborator team, 47 recommendations were generated to provide guidance on the risk factors for and the prevention, diagnosis, and management of PDPH, along with ratings for the strength and certainty of evidence. A 90% to 100% consensus was obtained for almost all recommendations. Several recommendations were rated as having moderate to low certainty. Opportunities for future research were identified.Conclusions and RelevanceResults of this consensus statement suggest that current approaches to the treatment and management of PDPH are not uniform due to the paucity of evidence. The practice guidelines, however, provide a framework for individual clinicians to assess PDPH risk, confirm the diagnosis, and adopt a systematic approach to its management.
Bone Regeneration in a Large Animal Model Featuring a Modular Off‐the‐Shelf Soft Callus Mimetic
Authors: de Silva Leanne , Longoni Alessia , Staubli Flurina , Nurmohamed Silke , Duits Anneli , Rosenberg Antoine J. W. P. , Gawlitta Debby 
Published: August 2023

AbstractImplantation of engineered cartilage with soft callus features triggers remodeling to bone tissue via endochondral bone regeneration (EBR). Thus far, EBR has not progressed to the level of large animals on the axis of clinical translation. Herein, the feasibility of EBR is aimed for a critical‐sized defect in a large animal model. Chondrogenesis is first induced in goat‐derived multipotent mesenchymal stromal cells (MSCs) by fine‐tuning the cellular differentiation process. Through a unique devitalization process, two off‐the‐shelf constructs aimed to recapitulate the different stages of the transient cartilaginous soft callus template in EBR are generated. To evaluate bone regeneration, the materials are implanted in an adapted bilateral iliac crest defect model in goats, featuring a novel titanium star‐shaped spacer. After 3 months, the group at the more advanced differentiation stage shows remarkable regenerative capacity, with comparable amounts of bone regeneration as the autograft group. In contrast, while the biomaterial mimicking the earlier stages of chondrogenesis shows improved regeneration compared to the negative controls, this is subpar compared to the more advanced material. Concluding, EBR is attainable in large animals with a soft callus mimetic material that leads to fast conversion into centimeter‐scale bone, which prospects successful implementation in the human clinics.
Peroxidation and Skeletal Rearrangement for the Synthesis of Dioxole‐2‐Carboxamide Derivatives under Continuous‐Flow Conditions
Authors: Ubale Akash S. , Shaikh Moseen A. , Mohanta Nirmala , Gnanaprakasam Boopathy 
Published: August 2023

AbstractHerein, we report peroxidative dearomatization of 2‐naphthol and C−H peroxidation of 3‐arylbenzofuran‐2‐ones with 66–94% yield under catalyst‐free conditions using continuous flow module. Besides, an approach for the synthesis of N‐substituted‐2‐phenylbenzo[d][1,3]dioxole‐2‐carboxamide has been achieved via the skeletal rearrangement of peroxybenzofuranone using amines in the absence of catalyst under continuous flow. The mechanistic study suggests that this peroxidation reaction proceeds via free radical formation under thermolytic conditions.
Triple‐function Hydrated Eutectic Electrolyte for Enhanced Aqueous Zinc Batteries
Authors: Zhong Yunpeng , Xie Xuesong , Zeng Zhiyuan , Lu Bingan , Chen Gen , Zhou Jiang 
Published: August 2023

AbstractAqueous rechargeable zinc‐ion batteries (ARZBs) are impeded by the mutual problems of unstable cathode, electrolyte parasitic reactions, and dendritic growth of zinc (Zn) anode. Herein, a triple‐functional strategy by introducing the tetramethylene sulfone (TMS) to form a hydrated eutectic electrolyte is reported to ameliorate these issues. The activity of H2O is inhibited by reconstructing hydrogen bonds due to the strong interaction between TMS and H2O. Meanwhile, the preferentially adsorbed TMS on the Zn surface increases the thickness of double electric layer (EDL) structure, which provides a shielding buffer layer to suppress dendrite growth. Interestingly, TMS modulates the primary solvation shell of Zn2+ ultimately to achieve a novel solvent co‐intercalation ((Zn‐TMS)2+) mechanism, and the intercalated TMS works as a “pillar” that provides more zincophilic sites and stabilizes the structure of cathode (NH4V4O10, (NVO)). Consequently, the Zn||NVO battery exhibits a remarkably high specific capacity of 515.6 mAh g−1 at a low current density of 0.2 A g−1 for over 40 days. This multi‐functional electrolytes and solvent co‐intercalation mechanism will significantly propel the practical development of aqueous batteries.
Defect Rich Structure Activated 3D Palladium Catalyst for Methanol Oxidation Reaction
Authors: Zhang Xueting , Hui Lan , Yan Dengxin , Li Jinze , Chen Xi , Wu Han , Li Yuliang 
Published: August 2023

AbstractControlling the structure and properties of catalysts through atomic arrangement is the source of producing a new generation of advanced catalysts. A highly active and stable catalyst in catalytic reactions strongly depends on an ideal arrangement structure of metal atoms. We demonstrated that the introduction of the defect‐rich structures, low coordination number (CN), and tensile strain in three‐dimensional (3D) urchin‐like palladium nanoparticles through chlorine bonded with sp‐C in graphdiyne (Pd‐UNs/Cl‐GDY) can regulate the arrangement of metal atoms in the palladium nanoparticles to form a special structure. In situ Fourier infrared spectroscopy (FTIR) and theoretical calculation results show that Pd‐UNs/Cl‐GDY catalyst is beneficial to the oxidation and removal of CO intermediates. The Pd‐UNs/Cl‐GDY for methanol oxidation reaction (MOR) that display high current density (363.6 mA cm−2) and mass activity (3.6 A mgPd−1), 12.0 and 10.9 times higher than Pd nanoparticles, respectively. The Pd‐UNs/Cl‐GDY catalyst also exhibited robust stability with still retained 95 % activity after 2000 cycles. A defects libraries of the face‐centered cubic and hexagonal close‐packed crystal catalysts (FH‐NPs) were synthesized by introducing chlorine in graphdiyne. Such defect‐rich structures, low CN, and tensile strain tailoring methods have opened up a new way for the catalytic reaction of MOR.
Unlocking the Transition of Electrochemical Water Oxidation Mechanism Induced by Heteroatom Doping
Authors: Li Xuan , Deng Chen , Kong Yan , Huo Qihua , Mi Lingren , Sun Jianju , Cao Jianyong , Shao Jiaxin , Chen Xinbao , Zhou Weiliang , Lv Miaoyuan , Chai Xiaoyan , Yang Hengpan , Hu Qi , He Chuanxin 
Published: August 2023

AbstractHeteroatom doping has emerged as a highly effective strategy to enhance the activity of metal‐based electrocatalysts toward the oxygen evolution reaction (OER). It is widely accepted that the doping does not switch the OER mechanism from the adsorbate evolution mechanism (AEM) to the lattice‐oxygen‐mediated mechanism (LOM), and the enhanced activity is attributed to the optimized binding energies toward oxygen intermediates. However, this seems inconsistent with the fact that the overpotential of doped OER electrocatalysts (<300 mV) is considerably smaller than the limit of AEM (>370 mV). To determine the origin of this inconsistency, we select phosphorus (P)‐doped nickel‐iron mixed oxides as the model electrocatalysts and observe that the doping enhances the covalency of the metal‐oxygen bonds to drive the OER pathway transition from the AEM to the LOM, thereby breaking the adsorption linear relation between *OH and *OOH in the AEM. Consequently, the obtained P‐doped oxides display a small overpotential of 237 mV at 10 mA cm−2. Beyond P, the similar pathway transition is also observed on the sulfur doping. These findings offer new insights into the substantially enhanced OER activity originating from heteroatom doping.
Study on the hydraulic classification characteristics of micron‐sized silica particles
Authors: Zhang Yaheng , Tang Zhiyong 
Published: August 2023

AbstractThe present study investigates the motion characteristics of micron‐sized silica particles and how solid–water interaction regulates hydraulic classification. Two methods were evaluated for classifying micron‐sized silica particles. Using the small‐diameter cyclone for hydraulic classification of micron‐sized silica particles resulted in poor separation due to the short residence time of particles in the cyclone. Particle settling in still water showed that settling velocity, drag force, and virtual mass force increased with particle size, providing a basis for size classification. In the particle sedimentation process, drag force and gravity were dominant, with drag force reaching equilibrium with gravity in a fast time. The upward water flow was introduced to classify silica particles, with its superficial velocity between the settling terminal velocities of large and small particles, allowing large and small particles to flow to the overflow and underflow, respectively. The upward flow velocity was higher near the center of the flow field and lower near the wall, leading to a parabolic distribution pattern of the particle group along the radial position. In hydraulic sedimentation classification experiments of silica particles, the average particle size of the overflow sample was lower than that of the feed, and its size range was narrower, indicating the feasibility of hindered sedimentation by upward flow for classifying micron‐sized silica particles.
Preparation, characterization and wound‐healing effect of PEGylated nanoliposomes loaded with oleuropein
Authors: Alquraishi Rand , Al‐samydai Ali , Al Azzam Khaldun M. , Alqaraleh Moath , Al‐Halaseh Lidia , Sanabrah Alaa , Abu Hajleh Maha N. , Al Khatib Arwa , Alsaher Walhan , Negim El‐Sayed , Khleifat Khaled 
Published: August 2023

AbstractChronic wounds have become a major concern for healthcare systems, as they have been related to diabetic foot ulcers, venous leg ulcers and pressure ulcers. Oleuropein is an active compound that is extracted from olive leaves and it has the ability to reduce injury to tissues owing to its antioxidant effect, hence improving wound healing. The poor pharmacokinetics of oleuropein have limited its use clinically. This work is aimed toward studying the impact of PEGylated and non‐PEGylated nanoliposomes loaded with oleuropein, as a carrier model, on wound‐healing activity. The thin film hydration method was used to compose PEGylated and non‐PEGylated liposomes, both loaded with oleuropein. The results indicated that each free, PEGylated and non‐PEGylated composition was within the limit of optimum nanoliposome characterization. The results showed that non‐PEGylated compositions produced higher efficiency in encapsulation (47.09 ± 10.06%) than the PEGylated ones (20.97 ± 10.52%). The PEG‐nanoliposomes loaded with oleuropein (PEG‐oleu) had mean size, charge and polydispersity index of 129.35 nm, −9.55 mV and 0.1010, respectively. The scratch assay results proved that PEGylated liposomal compositions have a more rapid wound‐healing activity than non‐PEGylated ones at different time intervals at 0, 2, 24 and 28 h.
Can CEO environmental awareness promote new product development performance? Empirical research on Chinese manufacturing firms
Authors: Tang Jiawang , Liu Along , Gu Jibao , Liu Hefu 
Published: August 2023

AbstractDespite the growing interest in the role of chief executive officers' (CEOs') environmental awareness in enhancing performance, its impact on new product development (NPD) performance, as well as the underlying mechanisms and contextual bounds of the impact, remains unexplored. Based on upper echelons theory, we suggest that CEO environmental awareness promotes NPD performance through corporate environmental practice. We further theorize that the role of CEO environmental awareness is contingent on environmental institutional pressure. To validate the model, we collected survey data from 534 senior executives of 178 manufacturing firms in China. The main results show that corporate environmental practice completely mediates the relationship between CEO environmental awareness and NPD performance. The relationship is positively moderated by environmental normative pressure, whereas environmental regulatory pressure negatively moderates this process. Theoretical and practical implications of how to leverage CEO environmental awareness and environmental institutional pressure to boost NPD performance are discussed.
Gated Photochromism of Dithienylethene‐Embedded Expanded Calixphyrins
Authors: Zhang Fenni , Rao Yutao , Zhou Mingbo , Xu Ling , Osuka Atsuhiro , Song Jianxin 
Published: August 2023

AbstractDithienylethene (DTE)‐embedded expanded porphyrins were synthesized and confirmed to be photochemically inactive due to the lowest excited state of the expanded porphyrins. On the other hand, DTE‐embedded expanded calixphyrins exhibited reversible photochromism upon UV‐irradiation to form colored closed forms, which reverted to colorless open forms upon red‐light irradiation. The closed forms were oxidized with DDQ or the air to lock the recorded information by converting to photochemically inactive expanded porphyrins. This was unlocked by reduction with NaBH4 to restore expanded calixphyrins with photochromism activity. These gated photochromic behaviors were demonstrated in PMMA (polymethyl methacrylate) film.
CO2 Hydrogenation to Gasoline and Aromatics: Mechanistic and Predictive Insights from DFT, DRIFTS and Machine Learning
Authors: Ojelade Opeyemi A. 
Published: August 2023

AbstractThe emission of CO2 from fossil fuels is the largest driver of global climate change. To realize the target of a carbon‐neutrality by 2050, CO2 capture and utilization is crucial. The efficient conversion of CO2 to C5+ gasoline and aromatics remains elusive mainly due to CO2 thermodynamic stability and the high energy barrier of the C−C coupling step. Herein, advances in mechanistic understanding via Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS), density functional theory (DFT), and microkinetic modeling are discussed. It further emphasizes the power of machine learning (ML) to accelerate the search for optimal catalysts. A significant effort has been invested into this field of research with volumes of experimental and characterization data, this study discusses how they can be used as input features for machine learning prediction in a bid to better understand catalytic properties capable of accelerating breakthroughs in the process.
Forest management history influences eight decades of shallow landsliding in the northwest Cascade Mountains, USA
Authors: Seixas Gustav B. , Veldhuisen Curt N. 
Published: August 2023

AbstractForest management‐driven increases in landsliding may impact aquatic habitat and water quality, yet it is difficult to disentangle the effects of hydroclimate from evolving land‐use practices when interpreting landslide rate fluctuations over decadal timescales. We compiled shallow landslide inventories starting in the 1940s from nine small watersheds in the northwest Cascade Mountains, USA, and updated the mapping through 2019. We stratified the landscape by management regime (industrial/state and federally managed forests and forests with no history of management) and compared landslide volume generation rates against timeseries representing regional climate, precipitation and river discharge, timber harvest rate, and instability ratings from the topographic model SHALSTAB. Results demonstrate a bell‐shaped temporal trend in composite landsliding that peaked in the 1970s and 1980s and is unlikely to have arisen from random variation alone. The signal from unmanaged forests correlates with regionally warm/wet climatic conditions at decadal scales, but we found mixed quantitative support for storm hydrology in explaining the landslide trends. Landsliding in federal managed forests was greatly reduced following cessation of clearcut logging in the mid‐1990s in most basins. In contrast, topographic and stand age modelling suggest the private industrial and state forest trend is consistent with reduced landsliding resulting from regulations requiring hazard avoidance in logging unit design—not changes to logging rate—demonstrated by a decline in probability of recent clearcuts on highly unstable terrain relative to more stable terrain following the 1980s in most basins. The analysed covariates could not explain all trends in all watersheds, suggesting the presence of methodological or data‐based limitations in the analyses. Late 20th century landslide sediment delivery acutely impacted tributaries but likely became muted downstream due to lag effects and mixing with other sources; our results suggest that proximal sediment supply impacts may be greatly reduced.
Land surface diversity: A geomorphodiversity index of Italy
Authors: Burnelli Martina , Melelli Laura , Alvioli Massimiliano 
Published: August 2023

AbstractGeomorphodiversity refers to the variety of landforms and morphological processes characterizing the landscape. The definition of an index to quantify geomorphodiversity is a relevant step for multiple fields of Earth sciences, since it is widely accepted that the variability of the geosphere deeply influences the diversity of the biosphere. Such an index should describe the number and type of landforms and geomorphological processes. We propose a quantitative land surface diversity index valid for Italy, considering multiple input quantities to describe geological constraints and geomorphological processes. Critical issues were the selection of moving window size for focal statistics operations, to calculate local diversity of slope, lithology, drainage density and terrain forms in individual raster maps. We compared the index with traditional geomorphological maps, in selected locations, in which information was available. Results show that a minimal set of heterogeneous data is a satisfactory approach to investigate the landscape diversity. Relating processing parameters and terrain spatial characteristics to the dataset resolution is a good choice to assess a reproducible land surface diversity index. Inclusion of drainage density allows the improvement of results in flat areas, in which other factors show trivial results. We argue that the index is relevant for land use management, assessment of ecodiversity, and it may help describing the interaction between abiotic and biotic compartments.