bluuebunny/crossref_metadata_2025_split huggingface dataset:
“I can’t see anything but upside”: A qualitative study of clients’ experiences on North America’s first take-home injectable opioid agonist treatment (iOAT) program
Authors: Oviedo-Joekes Eugenia , Dobischok Sophia , Carvajal José , MacDonald Scott , McDermid Cheryl , Klakowicz Piotr , Harrison Scott , Lajeunesse Julie , Chow Nancy , Brown Murray , Gill Sam , Schechter Martin 
Published: February 2023

Abstract
Background

To support public health measures during the Covid-19 pandemic, oral opioid agonist treatment (OAT) take-home doses were expanded in Western countries with positive results. Injectable OAT (iOAT) take-home doses, which were previously not recommended, were made available for the first time in several sites to align with public health measures. Building upon these temporary risk-mitigating guidelines, a clinic in Vancouver, BC continued to offer two of a possible three daily doses of take-home injectable medications to eligible clients. The present study explores the processes through which take-home iOAT doses improved clients’ quality of life and continuity of care in real-life settings.

Methods

Three rounds of semi-structured qualitative interviews were conducted over a period of seventeen months beginning in July 2021 with eleven participants receiving iOAT take-home doses at a community clinic in Vancouver, BC. Interviews followed a topic guide that evolved iteratively in response to emerging lines of inquiry. Interviews were recorded, transcribed, and then coded using NVivo 1.6.

Results

Participants reported that take-home doses granted them the freedom away from the clinic to have daily routines, form plans, and enjoy unstructured time. Participants appreciated the greater privacy, accessibility, and ability to engage in paid work. Furthermore, participants enjoyed greater autonomy to manage their medication and level of engagement with the clinic. These factors contributed to greater quality of life and continuity of care. Participants shared that their dose was too essential to divert and that they felt safe transporting and administering their medication off-site. In the future, participants would like to access longer take-home prescriptions, the ability to pick-up at different and convenient community pharmacies, and a medication delivery service.

Conclusions

Reducing the number of daily onsite injections from two or three to only one revealed the diversity of rich and nuanced needs that added flexibility and accessibility in iOAT can meet. Urgent action such as policy reform and licencing diverse opioid medications/formulations is necessary to make these measures permanent and meet the varied needs and preferences of OUD clients.
Factors influencing the acceptance or rejection of dietary and body norm systems favorable to the prevention and control of type 2 diabetes among Sub-Saharan Africa migrants: A scoping review protocol
Authors: Ntanda Gisèle Mandiangu , Sia Drissa , Beogo Idrissa , Baillot Aurélie , Tchouaket Eric Nguemeleu 
Published: February 2023

Abstract

Background: The number of people living with type 2 diabetes (T2D) is increasing worldwide. The prevalence rate of this disease is generally higher in the migrant population compared to the general population. However significant inequalities in the prevalence of T2D are notable between and within migrant populations. Among them, migrants from sub-Saharan Africa, South America and South Asia are more affected than those of European origin. The act of eating and the corporality play an essential role in the development of this disease. Dietary and body norms systems favorable to the prevention and control of type 2 go against what is vital for most of these people, exposing them to conflicts of norms that are difficult to reconcile.
Objectif: to identify factors that may influence the acceptance or rejection of dietary and body norm systems favorable to the prevention and control of T2D by Sub-Saharan Africa migrants living with T2D.
Materials and methods: Scoping review according to the steps described by Arksey and O'Malley (2005) will be conducted. An electronic search of studies from 2011 to 2022, published English, Italian, French or in Portuguese will be conducted in eight databases (CINAHL, Cochrane library, Embase, Google Scholar, PsycInfo, PubMed, Scopus, and Web of Sciences). The grey literature including publication in Open Grey database and Website of non-governmental organizations working on migrant from Sub-Saharan Africa will be searched. All articles related to body norms, dietary behaviors, or determinants of body behaviors and dietary of migrants from Sub-Saharan Africa and those related to factors that influence acceptance or rejection of dietary and body norms systems favorable to the prevention and control of T2D among the migrants from Sub-Saharan Africa living with T2D or at risk to develop this disease will be included. This scoping review will be reported following the Standard Protocol Items: Recommendations for interventional Trials (SPIRIT) and Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines.
Results: The results will focus on factors influencing the acceptance or rejection of dietary and body norms systems favorable to the prevention and control of T2D among the migrants from Sub-Saharan Africa living with T2D or at risk to develop it.
When psychiatry goes to school: a qualitative study on the increase of psychiatric care in middle schools in the state of São Paulo, Brazil
Authors: Pietrobon Tania , Digiovanni Madeline , Michel Alexandre , Moro Marie-Rose , Benoit Laelia 
Published: February 2023

Abstract
Introduction:
Brazilian education follows an inclusion model of special education and utilizes school-based mental health centers, leading to the medicalization of student concerns and raising questions about the link between schooling and children’s psychopathology. How do professionals in the education sector define their roles regarding students’ mental health?
Methods:
Twenty-one semi-directive interviews were conducted between March and June 2018 in five schools and two universities in the state of Sao Paulo, Brazil. Transcripts were analyzed using a grounded theory approach.
Results:
We identified three overarching domains: 1) a reported increase in the number of students with a psychiatric diagnosis, 2) teachers’ discourse on the influence of inclusive education policies on their daily practice, and 3) how socioeconomic differences drive selective medicalization of student concerns.
Conclusion:
In Brazil, selective medicalization has evolved differently in the public and private school systems, reinforcing inequalities already present in care and education.
Resetting the Baseline: Using Machine Learning to Find Lost Meadows
Authors: Cummings Adam K. , Pope Karen L. , Mak Gilbert 
Published: February 2023

Abstract
Context.
Mountain meadows occur in specific geomorphological conditions where low-gradient topography promotes fine sediment accumulation and high groundwater tables. Over 150 years of human-caused hydrological degradation of meadows along with fire suppression has resulted in decreased groundwater elevations and encroachment of upland vegetation, greatly diminishing the ecological value of meadows for water storage, baseflow, sediment capture, wildfire resistance, wildlife habitat, and carbon storage.
Objectives.
We aimed to understand where and how frequently meadows historically occurred to reset the baseline condition and provide insight into their restoration potential. We trained machine learning algorithms to identify potential meadow areas with similar hydrogeomorphic conditions to extant meadows while ignoring their unique vegetative characteristics since we hypothesized that vegetation would change but geomorphology would remain.
Methods.
We used a publicly available dataset of over 11,000 hand-digitized meadow polygons occurring within a 25,300 km2, 60-watershed region in the Sierra Nevada, California USA to train random forest models to detect meadow-like hydrogeomorphic conditions. Predictor variables represented topographical position, flow accumulation, climate, and topographical relief at differing scales. We assessed model performance and produced maps delineating high probability meadow polygons.
Results.
Our findings showed that there is 2.6 to 8.3 times more potential meadow habitat than currently documented. The predicted area includes a mixture of existing but undocumented meadows, non-meadow habitats that may have converted from meadows due to lost function and forest encroachment, and areas with meadow-like geomorphology that may never have been meadows. The polygons encompassing predicted meadows often expanded existing meadows habitats into adjacent areas with continuous topography, but with upland vegetation and incised channels.
Conclusions.
Using readily available data and accessible statistical techniques, we demonstrate the accuracy of a tool to detect about five times more historical meadows than currently recognized within a complex, mountainous landscape. This “found” area greatly increases the potential area that could be subject to meadow restoration with benefits for biodiversity, wildfire management, carbon sequestration, and water storage.
Hybrid origin and status of the endangered Ilex sanqingshanensis revealed by molecular and morphological evidence
Authors: Liu Wei-li , Li Dan-qi , Zou Yi-ping , Hao Ming-zhuo , Zhang Zhi-yong , Fan Deng-mei , Yang Yi 
Published: February 2023

Abstract

Identification of natural hybrids considered as endangered species is of vital importance in biodiversity conservation and taxonomy, as natural hybrids will usually waste the conservation resource and obscure the divergences between distinct species. During the field surveys in the Sanqing Mountain, we found the endangered endemic species,Ilex sanqingshanensis, strictly co-occurred withI.ficoideaandI.pernyiand then supposed a hybrid origin for this taxon. Combing the molecular analyses of ITS and cpDNA (petA-psbJ + psbA-trnH) with the morphological analyses of eight leaf characters, we confirmed this taxon to be a hybrid betweenI.ficoideaandI.pernyiand accepted it asI. ×sanqingshanensis. Despite the presence of intermediacy in morphology, this hybrid is sharply distinct from the two parents in all tested traits, misleading the botanists to treat it as a species. Considering the inadequacies of morphological distinctions in distinguishing holly hybrids, we have emphasized the necessity of molecular evidence for erectingIlexspecies.
Tailoring the Performance of Nanocellulose-based Multilayer-Barrier Paperboard using Biodegradable-Thermoplastics, Pigments, and Plasticizers
Authors: Koppolu Rajesh , Lahti Johanna , Abitbol Tiffany , Aulin Christian , Kuusipalo Jurkka , Toivakka Martti 
Published: February 2023

Abstract
In this work a multilayer barrier paperboard was produced in a roll-to-roll process by slot-die coating of nanocellulose (microfibrillated cellulose (MFC) or carboxymethylated cellulose nanofibrils (CNF)) followedby extrusion coating of biodegradable thermoplastics (polylactic acid (PLA), polybutylene adipate terephthalate (PBAT) and polybutylene succinate (PBS)). Hyperplaty kaolin pigments were blended in different ratios into nanocellulose to tailor the barrier properties of the multilayer structure and to study their influence on adhesion to the thermoplastic top layer. Influence of a plasticizer (glycerol) on flexibility and barrier performance of the multilayer structure was also examined.Water vapor permeance for the multilayer paperboard was below that of control single-layer thermoplastic materials, and oxygen permeance of the coated structure was similar or lower than that of pure nanocellulose films. Glycerol as a plasticizer further lowered the oxygen permeance and kaolin addition improved the adhesion at the nanocellulose/thermoplastic interface.The results provide insight into the role played by nanocelluloses, thermoplastics, pigments, and plasticizers on the barrier properties when these elements are processed together into multilayer structures, and paves the way for industrial production of sustainable packaging.
Multi-Objective Optimization Scheduling of Integrated Energy System Interval Under Multiple Uncertainty Environment
Authors: Zhao Lin , Hou Yixin , Jiang Haiwei , Liu Guangshuo , Yang Fangyuan 
Published: February 2023

Abstract
To solve influence of the uncertainty in integrated energy system on dispatch plan, a interval multi-objective optimization dispatch method of integrated energy system under multiple uncertain factors is proposed. Firstly, interval mathematics is used to describe multiple uncertain factors in the system, such as efficiency of multi-energy coupling unit, demand response, and electricity substitution; secondly, considering the efficient use of energy, the economics of system operation and difference in energy quality, optimize the operation of the system with goal of lowest system operating cost and highest exergy efficiency; finally, based on interval multi-objective linear programming method, an interval multi-objective optimization scheduling technique of integrated energy system under multiple uncertain factors is established. Case analysis shows that proposed multi-objective optimization scheduling method can take economics of system operation and exergy efficiency into account, and effectively improve the system's ability to deal with multiple uncertainties.
Fructose improves Titanium Dioxide Nanoparticles induced alterations in Developmental Competence of mouse oocytes
Authors: Elmetwally Mohammed A , Helmy Amal , Zaabel Samy , Montaser Abdelmonem , Balboula Ahmed , Eladl Mohamed , Hamed Basma , Lashen Samah , Rezk Shaymaa , Yaseen Amira , Sharawy Heba , Hussien Mamdouh , Halawa Amal 
Published: February 2023

Abstract
Aims: We investigated the effect of intraperitoneal titanium dioxide nanoparticles (TiO2 NPs, 100 mg/kg) for 5 consecutive days on the developmental competence of murine oocytes via its effects on the antioxidant and oxidative stress biomarkers as well as their effects on mRNAs expression for BAX, Caspase 3, P53 and hypoxia inducing factor-1α (HIF- 1). Moreover, the possible ameliorating effect of fructose (2.75 mM/ml) was examined.
Materials and methods: Thirty sexually mature (8-12 weeks old; ~ 25 g body weight) female mice were used for the current study. The female mice were divided into three groups as follows:
Group1 (G1): Female mice received deionized water and the collected oocytes were cultured in global® total media (control group). Group 2 (G2): Female mice received TiO2 NPs at a dose of 100 mg/kg BW by i/p injection for 5 consecutive days, and the collected oocytes were cultured in global® total media. Group 3 (G3): Female mice received TiO2 NPs at a dose of 100 mg/kg BW + fructose 2.75 mM by i/p injection for 5 consecutive days, and the collected oocytes were cultured in global® total media.
Results: Nano-titanium significantly decreased GSH, GPx, and NO while MDA and TAC were increased. The rate of MI, MII, GVBD and degenerated oocytes were significantly decreased. Meanwhile, the rate of activated oocytes was significantly increased. TiO2 NPs significantly upregulated the relative expression of apoptotic genes (BAX, Caspase 3 and P53) and HIF-1. Intraperitoneal fructose (2.75 mM/kg) significantly alleviated the detrimental effects of TiO2 NPs. The transmission electron microscopy showed the ability of the fructose to maintain the surface of murine oocytes.
Conclusion: Collectively, these results suggest that the i/p infusion of fructose for consecutive 5 days promote the oocyte development and decrease the toxic effects of TiO2 NPs by changing the oxidative and antioxidant biomarkers secreted by COCs and affects the mRNAs expression of apoptotic and hypoxia inducing factor.
Reliability evaluation of a dynamic pressure mechanical seal based on liquid film vaporization phase transition
Authors: Xu Xiaodong , Bei Guangyao , Ma Chenbo , Sun Jianjun , Zhang Yuyan , Yu Qiuping 
Published: February 2023

Abstract
As a key basic component for leakage prevention in rotating machinery, research on the reliability of mechanical seals has always been the focus of theoretical and practical investigations. A reliability evaluation method for the dynamic pressure mechanical seal based on liquid film vaporization phase transition is proposed. To investigate the affect of the mass transfer coefficient on the vaporization phase transition, a liquid film vaporization model of the hydrodynamic mechanical seal seal face has been established. The working condition parameters and groove structure parameters are selected based on experimental testing. The evaporation characteristics of liquid film under different parameter combinations are analyzed, and as a result, the function of the vaporization characteristics is obtained. The limit state equation of gas phase volume fraction is obtained by using the maximum gas phase volume fraction when the dynamic pressure mechanical seal state changes from liquid phase miscibility to gas phase miscibility. The structural parameters of the groove are sampled based on the Monte Carlo method, and the reliability is calculated using the sampling results and the limit state equation. Finally, the proposed method is used to numerically analyze the reliability of the slot under specific structural parameters.
Variational Auto Encoder fused with Gaussian Process for Unsupervised Anomaly Detection
Authors: Guan Yaonan , Xu Yunwen , Li Dewei 
Published: February 2023

Abstract
The identification of abnormal data in high-dimensional and high-complexity situations is a challenging subject. In order to improve the accuracy of abnormal data detection, in this article, we first use Variational Auto Encoder (VAE) to extract the features of high-dimensional data to achieve the effect of data dimensionality reduction. Then the Gaussian process model is applied to establish the latent space's feature distribution field and guide the data's displacement in the latent space. The joint probability distribution matrix of the latent space data is adopted to establish the feedback channel between latent space data distribution and VAE data mapping. Finally, the characteristic distribution field of the Gaussian process model is fed back to the VAE to realize the separation of normal data and abnormal data at the data mapping level.
The environmental factors affecting the archaeological buildings in Egypt, “IV Deterioration by Synergistic Marine Effects”
Authors: El-Gohary Mohamed A. 
Published: February 2023

Abstract

This paper investigates the seismic actions that affect Qait Bey Fortress in Alexandria- Egypt. It presents the results of scientific studies and examinations to evaluate the deterioration conditions, which affected archaeological buildings in themarine environment. In Alexandria, many monumental sites and stone buildings have suffered from many aggressive factors of deterioration (mechanical, chemical, and biological), which have caused great harmful appearances and threatened to eradicate them. These effects include the chemical actions resulting from seawater and marine aerosol and mechanical actions of water waves. (Qait Bey Fortress), as a case study, was periodically investigated by many scientific techniques through 5 years to check their decay conditions and to define the most suitable conservation approaches and non-destructive methods for preservation. Different techniques and examinations were performed to evaluate the current deterioration state of the fortress. For example, XRD analysis and PM investigation were used to study the mineralogical compositions, lithotype, and petrographic characteristics of the stone samples. SEM was used to investigate the morphological features of the same samples. AAS was also used for studying the chemical constitutes of seawater samples. In addition, microbiological investigations were conducted to evaluate the colored hard crusts that affected the stone surfaces in the fortress. Our results proved that severe deterioration factors highly influenced the fortress by collaborating with chemical, mechanical and biological mechanisms. These mechanisms caused several manifestations, such asabrasionand attrition, crystallizing of salt species, mortar desegregation, pitting and minerals’ honeycomb (Alveolar), color changes, in addition to the accumulation of black and colored biogenic hard crusts.
SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML.
Authors: Mambro Antonella Di , Arroyo Yoana , Fioretti Tiziana , Randles Michael , Cozzuto Luca , Rajeeve Vinothini , Cevenini Armando , Austin Michael J. , Esposito Gabriella , Ponomarenko Julia , Lucas Claire M. , Cutillas Pedro , Gribben John , Williams Owen , Calle Yolanda , Wrench Bela , Esposito Maria Teresa 
Published: February 2023

Abstract
Background KMT2A-rearranged (KMT2A-R) is an aggressive and chemo-refractory acute leukemia which mostly affects children. Transcriptomics-based characterization and chemical interrogation identified kinases as key drivers of survival and drug resistance in KMT2A-R leukemia. In contrast, the contribution and regulation of phosphatases is unknown. We explored the role of SET, the endogenous inhibitor of SER/THR phosphatase PP2A in KMT2A-R leukemia.
Material and Methods The expression of SET was analysed in a large acute myeloid leukemia (AML)- RNA-seq dataset and in primary KMT2A-R samples and aged matched-controls. Stable SET knockdown (KD) was established by RNA interference in three KMT2A wild-type (wt) and four KMT2A-R leukemic cell lines. Gene and protein expression were analysed by RT-qPCR, ChiP, IP and western blot. RNA-seq and phospho-proteomics were employed to evaluate the effect of the SET-PP2A inhibitor FTY720 on global protein phosphorylation and gene expression. The cellular impact of FTY720 was evaluated by analysing proliferation, cell cycle and apoptosis in leukemic cell lines and by colony formation assay in two patient-derived xenograft (PDX).
Results SET mRNA was found expressed in blasts from KMT2A-R-patients and in leukemic stem cells. SET protein interacted with both KMT2A wt and fusion proteins. Knockdown of SET inhibited the transcription of KMT2A target genes HOXA9 and HOXA10and abolished the self-renewal of KMT2A-R leukemic cells. Pharmacological inhibition of SET by FTY720 disrupted SET-PP2A interaction leading to cell cycle arrest, apoptosis and increased sensitivity to chemotherapy in KMT2A-R-leukemic models. Phospho-proteomic and western blot analyses revealed that FTY720 reduced the activity of kinases regulated by PP2A, including ERK1, GSK3b, ARKB, and led to degradation of MYC, supporting the hypothesis of a feedback loop among SET, PP2A and MYC. The RNA-seq indicated that FTY720 reduced the activity of signalling pathways implicated in gene transcription and it compromised the expression of several genes belonging to the KMT2A-R leukemia signature.
Conclusions Taken together our results identify SET as a novel player in KMT2A-R leukemia and provide evidence that SET antagonism could serve as a novel strategy to treat this aggressive leukemia.