bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 14091: Severe Hypothyroidism Revealing Hidden Tracts
Authors: sharma arushi , shah shanil , Shireen Kanamgode Shihla , Kumar Nilesh , Home Madhurima 
Published: June 2023

Discussion:
Atrioventricular reciprocating tachycardia (AVRT) is a type of Supraventricular tachycardia (SVT) caused by an accessory pathway can result in symptomatic and also life-threatening arrhythmias. Supraventricular tachycardias are less commonly seen in hypothyroidism than hyperthyroidism. We present a case of a 41 year old gentleman who presented with chest pain and SVT was found to have severe hypothyroidism with pre-excitation pattern on his EKG.
Case:
41-year-old Caucasian gentleman with history of untreated Hashimoto’s thyroiditis presented with palpitations and acute onset left-sided chest pain. His symptoms were aggravated with movement and improved with rest. When EMS found him, his vitals were significant for tachycardia with a heart rate (HR) of 200 beats per minute (bpm). EKG showed supraventricular tachycardia. Vagal maneuvers were attempted followed by adenosine. This resulted in conversion to sinus rhythm and improvement in HR to 88 bpm. His chest pain completely resolved. He was then brought to the emergency room where he had normal vitals. Examination revealed thyroid gland was palpable and noted to be diffusely enlarged. Laboratory data was significant for an elevated thyroid-stimulating hormone (TSH) of 373 mIU/ml and undetectable free thyroxine (fT4) levels. His creatinine kinase (CK) was high at 16260, and troponin was elevated at 0.220 ng/ml (reference:<0.04 ng/ml). TPO antibodies were >600 IU/ml. EKG demonstrated sinus rhythm with pre-excitation and incomplete left bundle-branch block.
He had normal chest x-ray. An echocardiogram showed an ejection fraction of 55% with mild LV diastolic dysfunction. He later underwent a stress myocardial perfusion scan which showed no definite evidence of inducible ischemia.
Follow up:
He was started on thyroxine replacement therapy. He is due for an EP study to evaluate for an accessory pathway causing pre-excitation with repolarization pattern on his ECG.

Conclusion:
This case suggests that severe hypothyroidism can also cause supraventricular tachycardias (SVT) by metabolic and conduction derangements revealing concealed bypass tracts in patients with accessory pathways. In most cases these arrhythmias are reversible once the underlying thyroid disorder is treated.
Abstract 14234: A Long-Standing Instance of Undiagnosed Misplaced Pacemaker Lead
Authors: Shah Aangi J , Zaman Muhammad O , McHale Joseph F , APTE NACHIKET MADHAV 
Published: June 2023

Introduction:
Misplacement of pacemaker (PCM) lead into the left ventricle (LV) is a rare complication with an incidence of 0.34%. Limited cases of long-standing misplaced leads have been reported in the past. We present a case of misplaced PCM lead in the LV that went undiagnosed for 10 years, complicated by thrombotic strokes.

Case information:62-year-old male with history of sick sinus syndrome and a dual chamber PCM implantation, and thrombotic strokes with residual neurological deficits while on warfarin, presented to our hospital with gastrointestinal bleeding, subdural hematoma, and pulmonary embolism, in the setting of a mechanical fall. The patient had undergone a PCM implantation 10 years ago, and had a recent generator change 6 months prior to his presentation.
Diagnosis: Chest X-ray on admission was suggestive of misplaced PCM lead in the LV which was later confirmed by transesophageal echocardiography, that showed PCM lead attached to the postero-lateral wall of the LV.
Management: Given the patient’s complex presentation, a multi-disciplinary team approach was pursued. The patient was cautiously challenged with heparin drip with simultaneous serial hemoglobin and repeat CT head monitoring. The misplaced lead was determined as the likely culprit for the recurrent strokes. Since percutaneous lead extraction posed a high risk of complications, surgical correction was performed. The patient subsequently underwent a successful percutaneous dual chamber PCM implantation with His bundle pacing.

Conclusion:
Our case highlights a long-standing instance of misplaced PCM lead and consequent recurrent thrombotic strokes. We chose surgical correction over of percutaneous extraction given high risk of LV rupture and systemic thromboembolism with lead traction.
Abstract 15535: A Case of Suspected Menstruation Induced QTc Prolongation Leading to Torsades De Pointes
Authors: Gardy Adam , Miller Joselyn , Konstantinidis Ippokratis , Ferreira Jennifer , Conner Chad , Saucier Stephanie 
Published: June 2023

Estrogen is known to produce changes in cardiac electrophysiology specifically in premenopausal women, increasing the risk of arrhythmias. We report a case of Torsades de Pointes (TdP) in a young premenopausal female.
A 25-year-old female with a history of anxiety presented to the emergency room (ED) with several days of vomiting. While in the ED, she had an unwitnessed syncopal event, and was found to be in pulseless ventricular fibrillation (V-Fib) . She required one defibrillation to obtain return of spontaneous circulation (ROSC). Initial work up showed calcium 7.6 mg/dl, phosphorous 1.1 mg/dl, magnesium 2.4 mg/dl, potassium 4.0 mg/dl. Remainder of electrolytes were normal. Toxicology screen was positive for cannabinoids. Post ROSC EKG showed sinus tachycardia at a rate of 103bpm with a prolonged QTc of 531ms. Patient was not on any medications outpatient. On further discussion, patient reported no prior history of syncopal episodes, palpitations, and denied any family history of sudden cardiac death. She did report she was presently on her menses. Shortly after admission, she had recurrent polymorphic ventricular tachycardia which degenerated to TdP. She was loaded with magnesium. Echocardiogram showed an ejection fraction (EF) of 35-39% and global hypokinesis. Diagnostic left heart catheterization was performed revealing clean coronaries. Cardiac MRI revealed EF of 43% without any late gadolinium enhancement. Her QTc remained prolonged even with electrolyte normalization. She underwent successful ICD placement and remained event free during the remainder of the hospital course. She will undergo genetic work up for long QT syndrome.
Female sex hormones, specifically estrogen, have been described in literature as pro-arrhythmic given its effects on QT prolongation and ion gated channels. Prior cases of menstruation dependent arrhythmias have speculated that the abrupt reduction in estradiol prior to menstruation is associated with increased cyclic adenosine monophosphate dependent arrhythmogenicity. This case highlights the multifactorial etiology of sudden V-Fib arrest in a young female, and the importance of understanding the role that sex hormones play in the underlying pathogenesis.
Abstract 15603: Simultaneous Suction Debulking of a 3 Cm Lead Vegetation in the Right Ventricle During Extraction
Authors: Mazhar Naveed , Jamal Shakeel , Sheikh Ali , Qintar Mohammed , Osman Abdul-Fatawu 
Published: June 2023

A 49-year-old male with a history of NICM EF 25% with dual-chamber AICD, lupus with nonbacterial endocarditis of aortic valve, IVC filter for recurrent DVT/PE presented with septic shock due to MRSA osteomyelitis and bacteremia. TTE showed 1.8 cm vegetation. The patient had idiopathic thrombocytopenic purpura, for which IVIG was administered. To avoid obligatory systemic exposure to heparin in the setting of ITP with a larger evacuation system and crossing the IVC filter with a large bore cannula, it was decided to proceed with Penumbra evacuation of lead vegetation with simultaneous laser extraction. A short 16F sheath was inserted through the right femoral vein for the procedure. A12F Medtronic Cryo Flex sheath was advanced through the IVC filter under fluoroscopy to provide steerability in the right atrium. TEE-guided Flex sheath positioned abutting the mass/vegetation. Suction only partially retrieved the mass. RA lead was removed using mechanical extraction tools via the left chest pocket. On repeat TEE evaluation, the mass/vegetation was 3 cm on the RV lead. Since we could not aspirate the mass, we used the extraction tools to peel the mass off the lead while providing simultaneous negative suction through the Penumbra cannula. The lead was successfully extracted. TEE showed no residual mass, no significant change in tricuspid regurgitation and no pericardial effusion. Mass biopsy showed calcified blood clots. The patient was discharged on IV antibiotics.
Discussion:
Most cases to date report using larger systems like AngioVac for extracting larger vegetations/masses with lead extraction. Aspiration tools have been shown to extract malleable masses with lesser procedural-related morbidity. Peeling and aspiration can be used concurrently to remove these masses without significant blood loss, downstream sheading and the need for systemic anticoagulation. Further technique development can benefit in removing under such challenging scenarios.
Loss of PI3Kα Mediates Protection From Myocardial Ischemia–Reperfusion Injury Linked to Preserved Mitochondrial Function
Authors: Zhabyeyev Pavel , McLean Brent , Bassiouni Wesam , Valencia Robert , Paul Manish , Darwesh Ahmed M. , Seubert John M. , Hazra Saugata , Oudit Gavin Y. 
Published: June 2023

Background
Identifying new therapeutic targets for preventing the myocardial ischemia–reperfusion injury would have profound implications in cardiovascular medicine. Myocardial ischemia–reperfusion injury remains a major clinical burden in patients with coronary artery disease.

Methods and Results

We studied several key mechanistic pathways known to mediate cardioprotection in myocardial ischemia–reperfusion in 2 independent genetic models with reduced cardiac phosphoinositide 3‐kinase‐α (PI3Kα) activity. P3Kα‐deficient genetic models (PI3KαDN and PI3Kα‐Mer‐Cre‐Mer) showed profound resistance to myocardial ischemia–reperfusion injury. In an ex vivo reperfusion protocol, PI3Kα‐deficient hearts had an 80% recovery of function compared with ≈10% recovery in the wild‐type. Using an in vivo reperfusion protocol, PI3Kα‐deficient hearts showed a 40% reduction in infarct size compared with wild‐type hearts. Lack of PI3Kα increased late Na
+
current, generating an influx of Na
+
, facilitating the lowering of mitochondrial Ca
2+
, thereby maintaining mitochondrial membrane potential and oxidative phosphorylation. Consistent with these functional differences, mitochondrial structure in PI3Kα‐deficient hearts was preserved following ischemia–reperfusion injury. Computer modeling predicted that PIP3, the product of PI3Kα action, can interact with the murine and human Na
V
1.5 channels binding to the hydrophobic pocket below the selectivity filter and occluding the channel.

Conclusions

Loss of PI3Kα protects from global ischemic–reperfusion injury linked to improved mitochondrial structure and function associated with increased late Na
+
current. Our results strongly support enhancement of mitochondrial function as a therapeutic strategy to minimize ischemia–reperfusion injury.
Prolylcarboxypeptidase Alleviates Hypertensive Cardiac Remodeling by Regulating Myocardial Tissue Angiotensin II
Authors: Nguyen Binh Y. , Zhou Fangchao , Binder Pablo , Liu Wei , Hille Susanne S. , Luo Xiaojing , Zi Min , Zhang Hongyuan , Adamson Antony , Ahmed Fozia Z. , Butterworth Sam , Cartwright Elizabeth J. , Müller Oliver J. , Guan Kaomei , Fitzgerald Elizabeth M. , Wang Xin 
Published: June 2023

Background
Prolonged activation of angiotensin II is the main mediator that contributes to the development of heart diseases, so converting angiotensin II into angiotensin 1‐7 has emerged as a new strategy to attenuate detrimental effects of angiotensin II. Prolylcarboxypeptidase is a lysosomal pro‐X carboxypeptidase that is able to cleave angiotensin II at a preferential acidic pH optimum. However, insufficient attention has been given to the cardioprotective functions of prolylcarboxylpeptidase.

Methods and Results
We established a CRISPR/CRISPR‐associated protein 9–mediated global prolylcarboxylpeptidase‐knockout and adeno‐associated virus serotype 9–mediated cardiac prolylcarboxylpeptidase overexpression mouse models, which were challenged with the angiotensin II infusion (2 mg/kg per day) for 4 weeks, aiming to investigate the cardioprotective effect of prolylcarboxylpeptidase against hypertensive cardiac hypertrophy. Prolylcarboxylpeptidase expression was upregulated after 2 weeks of angiotensin II infusion and then became downregulated afterward in wild‐type mouse myocardium, suggesting its compensatory function against angiotensin II stress. Moreover, angiotensin II–treated prolylcarboxylpeptidase‐knockout mice showed aggravated cardiac remodeling and dampened cardiac contractility independent of hypertension. We also found that prolylcarboxylpeptidase localizes in cardiomyocyte lysosomes, and loss of prolylcarboxylpeptidase led to excessive angiotensin II levels in myocardial tissue. Further screening demonstrated that hypertrophic prolylcarboxylpeptidase‐knockout hearts showed upregulated extracellular signal‐regulated kinases 1/2 and downregulated protein kinase B activities. Importantly, adeno‐associated virus serotype 9–mediated restoration of prolylcarboxylpeptidase expression in prolylcarboxylpeptidase‐knockout hearts alleviated angiotensin II–induced hypertrophy, fibrosis, and cell death. Interestingly, the combination of adeno‐associated virus serotype 9–mediated prolylcarboxylpeptidase overexpression and an antihypertensive drug, losartan, likely conferred more effective protection than a single treatment protocol to mitigate angiotensin II–induced cardiac dysfunction.

Conclusions
Our data demonstrate that prolylcarboxylpeptidase protects the heart from angiotensin II–induced hypertrophic remodeling by controlling myocardial angiotensin II levels.
Contested Religious and Cultural Issues
Authors: Mbaya Henry 
Published: June 2023

Abstract
This article discusses the encounter between the missionaries of the Glasgow Missionary Society (Free Church of Scotland, hence Presbyterians), and the Wesleyans (Methodists) in the nineteenth century and the AmaXhosa in the Eastern Frontier of the Cape Colony. It specifically highlights the AmaXhosa’s contestations of some European Christian teachings, cultural values, and a way of life, which the Presbyterian and Wesleyan missionaries tried to impose on them in the process of ‘Christianizing’ and ‘civilizing’ them. The study illustrates that contrary to the commonly held conception that the Xhosa readily embraced the gospel, conversion to Christianity was a long and drawn-out process that entailed contestations and resistance on many levels and in many forms.
The Beginnings of African American Pentecostalism
Authors: Melton J. Gordon 
Published: June 2023

Abstract
African American response to the pentecostal movement began soon after the introduction of the Apostolic Faith to Texas, where the movement experienced its first noticeable success. It spread within the Black community of Houston following the baptism of the Holy Spirit by Holiness minister Lucy Farrow. One of its number, William Seymour, introduced it to Southern California. An early congregation in Houston became the first congregation affiliated with the Church of God in Christ, which, by the mid-1920s, became the largest pentecostal denomination in the state. Toward the end of the second decade of the century, Robert C. Lawson introduced the Pentecostal Assemblies of the World to San Antonio. The story of Black Pentecostalism’s emergence in Texas underscores the importance of African Americans to the larger pentecostal narrative even as it highlights the role of Texas in hosting the early expansion of the Apostolic Faith.
Toward a Holistic Pentecost
Authors: Stone Selina 
Published: June 2023

Abstract
Pentecostalism is often celebrated as a holistic or embodied spirituality that overcomes the dualisms inherent to modernity, and that juxtapose the body and the spiritual. However, historically and in the present, pentecostals struggle to address the problems of inequity and oppression that impact certain bodies in the church and the world. This article explores this tension in Classical Pentecostalism with a focus on Azusa Street and contemporary Pentecostalism in Britain. Through a case study of a “progressive” pentecostal church, I demonstrate that even in contexts that prioritize social engagement, the realities of class, race, and gender oppressions can continue unnamed and unchallenged. Resources may be located, I argue, in the African roots of the movement that provide an integrated worldview in which all aspects of life are considered spiritual and thus the oppressed are empowered to resist social, economic, and political as well as spiritual oppression.
Exploring Experience
Authors: Åkerlund Truls , Andersen John Daniel 
Published: June 2023

Abstract
This article contributes to pentecostal research by arguing that applied phenomenology can enhance the understanding of pentecostal experience and enrich work with systematic theology by increasing the amount of relevant data. Phenomenology is especially appropriate for pentecostal theology and research due to the shared emphasis on embodiment, importance of experiences, consistency of appearances, and realism of phenomena. Despite this methodological fit, our systematic literature review reveals a lack of phenomenological works in the corpus of pentecostal studies, and we provide some considerations for integration and suggestions for further empirical research grounded in a phenomenological sensibility.
Bibliometrics and Pentecostal Scholarship
Authors: Eller Daniel W. , Isgrigg Daniel D. 
Published: June 2023

Abstract
The Society for Pentecostal Studies celebrated its fiftieth anniversary in 2020. To commemorate the half-century mark, the editors of Pneuma assembled a special issue that included a history of the Society. While the fiftieth-anniversary commemorative volume captured the growth of the Society, absent was a consideration of the impact of Pneuma. As such, the fifty-year anniversary deserves a more quantifiable discussion of the journal’s impact on scholarship. By using a combination of information science and theological reflection, this article offers fresh insights on the journal’s impact in the realm of scholarly publishing. It fleshes out significant theological trends in Pentecostalism covered in its fifty-year history using bibliometrics. An index of all 710 peer-reviewed research articles published from 1978 to 2022 was created. Bibliometrics were used to assess that scholarship’s impact, understand where pentecostal studies flourished, and uncover possible gaps in pentecostal research where further study may be needed. Bibliometric research in theological studies acts as a mirror for researchers by quantifiably reflecting trends in pentecostal research that may have been anecdotally assumed or overlooked altogether. It places possible bias into sharp focus and offers new tools for discussing sensitive research and publication issues such as gender politics, diversity, and inclusivity.
Of Social Discipline and Control
Authors: Neo Ric , Yin Jason 
Published: June 2023

Abstract
Recent scholarship on disinformation points to a range of adverse effects on society, including its potential to fragment institutions and incite violence. Despite this, little research has looked into the stratified effects of fake news in society – particularly on how minorities are disproportionately victimised by the problem. This study sets out to analyse the qualitative impact of fake news on racial, ethnic and sexual minority communities in Indonesia through the theory of gendered and stratified misinformation. Three research questions are addressed: first, what disinformation campaigns affecting minority groups have emerged in Indonesia? Next, how have these campaigns influenced and shaped social behavior of minorities? Lastly, how is the state implicated in the problem, and to what extent are state responses considered adequate? Drawing upon primary data collected through interviews with Indonesian citizens belonging to major minority groups, this study’s findings reveal the disproportionate impact fake news has on minority communities in Indonesia. It sheds light on how fake news has been weaponised by hegemonic groups in society to both amass various forms of political and religious capital, as well as to socially control and discipline minority groups. Furthermore, it shows how the state is implicated through politicised policing of fake news.
Satellite-Based Ranking of the World’s Hottest and Coldest Cities Reveals Inequitable Distribution of Temperature Extremes
Authors: Li Jiufeng , Zhan Wenfeng , Chakraborty T. C. , Liu Zihan , Du Huilin , Liao Weilin , Luo Ming , Li Long , Miao Shiqi , Fu Huyan , Wang Shasha , Huang Fan , Li Manchun 
Published: June 2023

Abstract
The identification of the world’s hottest and coldest cities fascinates both the public and the scientific community. However, the ranking of city temperatures, especially from the perspective of human discomfort, has been difficult. Here we estimated the monthly mean maximum and minimum 1-km resolution urban temperatures of 13,135 cities worldwide (2003–19) from the thermal discomfort perspective by combining in situ measurements, satellite-based land surface temperatures, fine-resolution intracity data, and reanalysis data. Manama, Bahrain, was identified as the hottest city (48.18° ± 1.31°C) and Yakutsk, Russia (−42.96° ± 0.72°C), as the coldest city. The global city temperatures followed a power-law pattern, characterized by cities with <0.3 million inhabitants covering 80% of the top 20% global cities with extreme temperatures. Our study reveals an inequitable pattern of global city temperature extremes and highlights the urgency of developing appropriate strategies to reduce climate change risks in small- and medium-sized cities with low development levels.
Remission of Type 2 Diabetes After Treatment With a High-Fiber, Low-Fat, Plant-Predominant Diet Intervention: A Case Series
Authors: Panigrahi Gunadhar , Goodwin Sally M. , Staffier Kara Livingston , Karlsen Micaela 
Published: June 2023

Background: Prevalence of type 2 diabetes (T2D) is rising, and its burden on the healthcare system remains a challenge. Consumption of a plant-predominant diet is a promising approach for achieving remission, which has emerged as a therapeutic target. Objective: To establish feasibility of achieving T2D remission with a plant-predominant diet in a cohort of free-living individuals. Methods: Patients referred to a wellness clinic were treated with a low-fat, whole food, plant-predominant diet while receiving standard medical treatment. Included patients were adults, mostly elderly, with HbA1c > 6.5%, with or without use of antidiabetic medications. Results: N = 59 patients were included in this analysis, with mean age 71.5 years (range 41-89). Twenty-two (37%) patients achieved T2D remission. Mean differences showed a significant decrease post-lifestyle change (T2) compared to prior to lifestyle change (T1) for the following outcomes [least squares mean difference (95% CI)]: BMI [−2.6 (−4.8, −.3)] kg/m2; HbA1c [ −1.3 (−1.6, −1.0)] %; and fasting glucose [−29.6 (−41.8, −17.5)] mg/dL. No significant differences were observed for systolic or diastolic blood pressure, HDL, LDL, or triglycerides. Conclusion: A lifestyle-based treatment intervention promoting adherence to a plant-predominant diet and integrated as part of routine care can successfully achieve T2D remission in wellness clinic patients.