bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular access for isolated hepatic perfusion in liver metastases. Place of artificial circulation. Literature review
Authors: Unguryan V. M. , Kazantsev A. N. , Belov Y. V. 
Published: July 2023

The use of an artificial circulation and endovascular technologies in the treatment of liver metastases of uveal melanoma is a highly relevant area. Uveal melanoma is a rare cancer from the uveal tract of the eye. The liver is the most common site of metastasis and is affected in 70-90% of cases, being the only site of metastasis in about 50% of cases. Survival ranges from two to three months. This literature review describes the following methods of treatment of liver metastases of uveal melanoma using a heart-lung machine: arterial (arterio-caval), portal (porto-caval), arterio-porto-caval, retrograde arterio-portal. Special attention is paid to the endovascular method of treatment.Literature sources were searched in the following electronic libraries: elibrary.ru, pubmed.ncbi.nlm.nih.gov, researchgate.net.
Features of coronary pathology and its relationship with myocardial fibrosis markers in patients with resistant hypertension
Authors: Lichikaki V. A. , Mordovin V. F. , Falkovskaya A. Yu. , Zyubanova I. V. , Manukyan M. A. , Solonskaya E. I. , Vtorushina A. A. , Khunkhinova S. A. , Skomkina I. A. 
Published: July 2023

Aim. To evaluate the severity of coronary atherosclerosis and its association with biochemical markers of fibrosis in patients with coronary artery disease (CAD) and resistant hypertension (RHT).Material and methods. The study included 39 patients with CAD and RHT. All patients underwent 24-hour blood pressure (BP) monitoring, office BP numbers were measured. Laboratory diagnostics included routine tests, as well as determination of serum lipocalin, plasma concentration of matrix metalloproteinases 2 and 9 (­MMP-2, MMP-9), tissue inhibitor of matrix metalloproteinases-1 (TIMP 1). Coronary atherosclerosis in patients was assessed retrospectively according to medical records with an assessment of the protocols of invasive coronary angiography and multislice computed tomography, performed no more than a year ago from the moment of inclusion in the study with no clinical signs of CAD progression. Obstructive atherosclerosis was considered a coronary artery narrowing by more than 50%.Results. Considering the results of previous coronary angiography, the patients were divided into two groups. In the first group (n=20), coronary artery stenosis was <50%, in the second (n=19) >50% (p<0,05). The compared groups of patients were comparable in sex, age, duration of hypertension, blood pressure level, and the number of antihypertensive drugs taken. There were no differences in blood lipid profile, basal glycemia, uric acid levels, and the frequency of previous cerebral accidents. However, the incidence of diabetes in group 2 was significantly higher (p<0,05). Additionally, there was a significant difference in serum levels of lipocalin and MMP-2 with higher values of these indicators in patients with coronary atherosclerosis stenosis (p=0,02).Conclusion. In patients with RHT with symptoms and signs of myocardial ische­­mia, the incidence of obstructive coronary atherosclerosis according to coronary angiography is 50%. Diabetes in this category of patients indicates a more frequent obstruction of coronary bed. An increase in the level of MMP-2 and lipocalin in this category of patients is associated with more severe coronary damage and can be considered as an indirect indicator of obstructive coronary atherosclerosis.
Significance of inflammation markers in patients with coronary microvascular dysfunction and non-obstructive coronary artery disease
Authors: Kop’eva K. V. , Maltseva A. N. , Mochula A. V. , Grakova E. V. , Smorgon A. V. , Gusakova А. M. , Zavadovsky K. V. 
Published: July 2023

Aim. To study the relationship of coronary microvascular dysfunction (CMD) with the levels of pro- and anti-inflammatory biomarkers in patients with preserved ejection fraction (LVEF) and non-obstructive coronary artery disease (CAD).Material and methods. The study included 118 patients (70 men, mean age, 62,0 [58,0; 69,0] years) with preserved LVEF (62 [59; 64] %) and non-obstructive CAD. Serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hsCRP), interleukin-1β, 6, and 10 were assessed initially by enzyme immunoassay. Coronary flow reserve (CFR) was assessed by dynamic single photon emission computed tomography. CFR ≤2 was a CMD marker.Results. Patients were divided into groups depending on CMD presence: group 1 included patients with CMD (n=45), and group 2 was the control group and included patients without CMD (n=73). HsCRP concentrations were 1,8 times higher (p=0,011) in group 1 compared to group 2. Interleukin-6 levels did not differ significantly between groups (p=0,842), while interleukin-10 concentrations were lower by 21,7 % (p=0,048), and interleukin-1β was 2,7 times higher (p=0,046) in group 1 compared to group 2. According to ROC analysis, hsCRP concentration ≥4,8 g/l (AUC=0,655; p=0,012), and NT-proBNP ≥950,6 pg/ml (AUC=0,792; p<0,001) were identified as markers associated with CMD in patients with non-obstructive CAD, while levels of interleukin-1β, 6 and 10 showed no diagnostic significance. Multivariate regression analysis showed that diastolic dysfunction (odds ratio, 3,27; 95% confidence interval, 2,26-5,64; p<0,001) and NT-proBNP ≥950,6 pg/ml (odds ratio, 2,07; 95% confidence interval, 1,56-4,12; p=0,023) were independent factors associated with CMD.Conclusion. We established that in patients with non-obstructive CAD, the pre­sence of CMD is associated with a higher expression of pro-inflammatory markers and a decrease in the expression of an anti-inflammatory marker, which may confirm the fact that chronic inflammation is one of CMD pathogenesis links.
What’s new for the clinician – summaries of recently published papers
Authors: Yengopal V 
Published: July 2023

Pain is an important physiological and emotional experience, whose intensity may vary with age, gender, emotional state, cultural background and previous pain experience.1 Almost 95% of patients undergoing orthodontic treatment have reported varying degrees of pain. After an orthodontic force is applied, an immediate and a delayed painful response occurs. While the cause of the immediate response was to be the compression of the periodontal ligament (PDL), the delayed response was attributed to the hyperalgesia of the PDL. This hyperalgesia is associated with prostaglandins which make the PDL sensitive to algogens released in the environment, such as histamine, bradykinin, serotonin and substance.
Gaps in childhood immunizations and preventive care visits during the COVID-19 pandemic: a population-based cohort study of children in Ontario and Manitoba, Canada, 2016–2021
Authors: Evans Andrea , Mahar Alyson L. , Deb Bhumika , Boblitz Alexa , Brownell Marni , Guttmann Astrid , Stukel Therese A. , Cohen Eyal , Sarkar Joykrishna , Eze Nkiruka , Katz Alan , Raveendran Tharani , Saunders Natasha 
Published: July 2023

Abstract
Objective
We aimed to estimate the changes to the delivery of routine immunizations and well-child visits through the pandemic.

Methods
Using linked administrative health data in Ontario and Manitoba, Canada (1 September 2016 to 30 September 2021), infants <12 months old (N=291,917 Ontario, N=33,994 Manitoba) and children between 12 and 24 months old (N=293,523 Ontario, N=33,001 Manitoba) exposed and unexposed to the COVID-19 pandemic were compared on rates of receipt of recommended a) vaccinations and b) well-child visits after adjusting for sociodemographic measures. In Ontario, vaccinations were captured using physician billings database, and in Manitoba they were captured in a centralized vaccination registry.

Results
Exposed Ontario infants were slightly more likely to receive all vaccinations according to billing data (62.5% exposed vs. 61.6% unexposed; adjusted Relative Rate (aRR) 1.01 [95% confidence interval (CI) 1.00-1.02]) whereas exposed Manitoba infants were less likely to receive all vaccines (73.5% exposed vs. 79.2% unexposed; aRR 0.93 [95% CI 0.92-0.94]). Among children exposed to the pandemic, total vaccination receipt was modestly decreased compared to unexposed (Ontario aRR 0.98 [95% CI 0.97-0.99]; Manitoba aRR 0.93 [95% CI 0.91-0.94]). Pandemic-exposed infants were less likely to complete all recommended well-child visits in Ontario (33.0% exposed, 48.8% unexposed; aRR 0.67 [95% CI 0.68-0.69]) and Manitoba (55.0% exposed, 70.7% unexposed; aRR 0.78 [95% CI 0.77-0.79]). A similar relationship was observed for rates of completed well-child visits among children in Ontario (aRR 0.78 [95% CI 0.77-0.79]) and Manitoba (aRR 0.79 [95% CI 0.77-0.80]).

Conclusion
Through the first 18 months of the pandemic, routine vaccines were delivered to children < 2 years old at close to pre-pandemic rates. There was a high proportion of incomplete well-child visits, indicating that developmental surveillance catch-up is crucial.
Low-flow extra-intracranial bypass in acute carotid and vertebrobasilar ischemic stroke (literature review)
Authors: Shcherbinin A.  V. 
Published: July 2023

Introduction. The effectiveness of the method of revascularization of the brain using extra‑intracranial bypass in chronic insufficiency of blood supply to the brain has been studied in several randomized multicenter studies. The analysis of available publications devoted to this technique for 10 years with acute strokes in the carotid basin and for 20 years with ischemic strokes in the vertebrobasilar basin was carried out.Aim. To improve the results of treatment of ischemic strokes with the help of emergency extra‑intracranial low‑flow bypasses in the acute and acute period. In 12 publications over the past 10 years, selected from the PubMed search engine, 194 cases of the use of emergency extra‑intracranial microbypasses in the acute and acute period of ischemic stroke in the carotid basin were identified, 127 cases of emergency extra‑intracranial bypass were found in 6 articles during the last 20 years in the acute phase of vertebra‑basilar area stroke. Middle patient age in carotid group was 61.9 years, and 65 years in vertebral patient’s group. The male / female ratio was 3 / 1. The main indications for the bypass creation were: worsening of neurologic deficit from 4 and more according to the Stroke Severity Scale of the US National Institutes of Health, mini mal or not significant computed tomography (CT) or diffusion‑weighted magnetic resonance imaging (DW‑MRI) ischemia brain changes (not lower than 8 points on the scale of assessment of initial changes in the computed tomographic (CT) examination for stroke Alberta Stroke Program Early CT Score, ASPECTS), signs of significant brachiocephalic arteries atherosclerotic stenosis. In 83 carotid group cases perfusion‑diffusion mismatch was distinguished before bypass creation. In 111 carotid cases and in priority of vertebra‑basilar cases clinic‑diffusion mismatch was the only indication for emergency extra‑intracranial bypass creation. During the first 24 hours 65 % of carotid group bypass were performed, in other 35 % of cases bypasses were performed during 1 week after the stroke onset. There were 78 % of good results (<2 on the Rankin outcome scale, mRS) and 22 % of poor (mRS >2) in carotid stroke group. Mortality was 3 %. In vertebral group, coma was not contraindication for emergence extra‑intracranial bypass creation. In most cases, 70 % of bypass were performed between superficial temporal artery and superior cerebellar artery. Mortality in vertebral stroke group was 5 %, mostly because of somatic pathology worsening. Good results were achieved in76 % of cases.Conclusion. In some cases of atherosclerotic carotid and vertebrobasilar ischemic stroke, results of recovery can be approved greatly with use of emergency low‑flow extra‑intracranial bypass, if intravenous thrombolysis and endovascular tromboextraction were failed.
Entropy generation of Al2O3/water nanofluid in corrugated channels
Authors: SAOUDI Leila , ZERAIBI Nordine 
Published: July 2023

The flow of nanofluids in a corrugated channel has been shown to have a significant impact on heat transfer performance, and has therefore become an important area of research. The ob-
jective of this paper is to understand the thermal behavior of Al2O3/water nanofluid in a sinu-soidal and square channel and to identify ways to optimize heat transfer performance in such configurations. For this purpose, a numerical simulation was conducted using ANSYS-Fluent software 16.0 on entropy generation and thermo-hydraulic performance of a wavy channel with the two corrugation profiles (sinusoidal and square). The analyses were carried out under laminar forced convection flow conditions with constant heat flux boundary conditions on the walls. The influence of various parameters, such as particle concentration (0–5%), particle di-ameter (10nm , 40nm and 60nm), and Reynolds number (200 < Re < 800) on the heat transfer, thermal, and frictional entropy generation, and Bejan number was analyzed. Moreover, the distribution of streamlines and static temperature contours has been presented and discussed, and a correlation equation for the average Nusselt number based on the numerical results is presented. One of the most significant results obtained is that the inclusion of nanoparticles (5% volume fraction) in the base fluid yielded remarkable results, including up to 41.92% and 7.03% increase in average Nusselt number for sinusoidal and square channels, respectively. The sinusoidal channel exhibited the highest thermo-hydraulic performance at Re= 800 and φ= 5%, approximately THP= 1.6.
In addition, the increase of nanoparticle concentration from 0% to 5% at Re= 800 and dnp= 10nm, diminishes the total entropy generation by 28.39 % and 22.12 % for sinusoidal and square channels, respectively, but when the nanoparticle diameter decreases from 60nm to 10nm at ϕ= 5% and Re= 800, the total entropy generation in the sinusoidal channel decreases by 34.85%, whereas in the square channel, it decreases by 20.05%. Therefore, rather than using a square channel, it is preferable and beneficial to use small values of nanoparticle diameter and large values for each of ϕ and Re in the sinusoidal wavy channel. Overall, the study of nanofluid flow in a wavy channel can provide valuable insights into the behavior of nanofluids and their potential applications in a variety of fields, including manufacturing, energy produc-tion, mining, agriculture, and environmental engineering.
Comparison of Asymmetric Dimethyl Arginine and Oxidative Stress Parameters in Obese Dogs and Dogs with Clinically Normal Body Condition Based on Routine Hemogram and Serum Biochemicals
Authors: Cihan H. , Tunca M. 
Published: July 2023

Background: Obesity, which has recently created many problems in humans and animals, is stated as being above 15-20% of normal body weight. This condition is commonly classified using body condition scoring in dogs. This study compared oxidative stress (malondialdehyde, catalase, superoxide dismutase), asymmetric dimethylarginine (ADMA), routine hemograms and biochemicals in obese dogs and dogs with normal body conditions. Methods: Blood samples were taken from 20 normal body condition and 20 obese dogs. ADMA, oxidative stress and routine hematologic and biochemical parameters were evaluated. Result: Platelet count (p = 0.009), blood urea nitrogen (p less than 0.001), cholesterol (p = 0.006), ADMA (p less than 0.05) and malondialdehyde (p less than 0.001) were statistically high, while superoxide dismutase and catalase (p less than 0.001 and p less than 0.001, respectively) were statistically low in the obese group than the normal body condition group. As a result, we think the interpretation of the indicated biomarkers may help evaluate obesity and related pathologies in dogs, monitor treatment, or help prevent potential problems associated with obesity.
Sufistic Meditation as a Form of Happiness Transformation
Authors: Naan Naan , Aisyah Siti 
Published: July 2023

This study focuses on the discussion of Sufistic meditation as a form of happiness transformation. A discussion that has long been the subject of study. Happiness itself is the hope of everyone, but in reality, the happiness obtained is only false happiness, not eternal happiness. In Buddhist rituals, meditation is a practice that must be done in any school of Buddhism, and this has been a tradition since time immemorial. In this study, meditation from the Sufism perspective is presented as a method to enhance the transformation of true happiness. Meditation according to Buddhism has the same essence as the ritual practices in Islam, only the terms used vary. In Sufism, meditation has a word equivalent to the terms mentioned in Islam, namely Dhikr, tafakkur, mujahadah, muraqobah, riyadhah, and uzlah. In addition, the concept of happiness from several perspectives is also discussed, such as happiness from the perspective of Western psychology, happiness from the Sufistic perspective, and happiness according to experts. The author uses this topic as a study to further explore that Islam also has meditation methods with its perspective, and this Sufistic-based meditation is very supportive to improve the transformation of our spirituality in general and happiness in particular. Kajian ini memfokuskan pada pembahasan tentang meditasi sufistik sebagai bentuk transformasi kebahagiaan. Suatu pembahasan yang sudah lama menjadi bahan kajian. Sebagaimana kebahagiaan itu sendiri menjadi harapan setiap orang, tetapi pada kenyataannya kebahagiaan yang diperoleh hanyalah kebahagiaan yang bersifat semu, bukan kebahagiaan yang abadi. Dalam ritual agama Buddha, meditasi adalah satu praktik yang harus dilakukan dalam aliran Buddhaisme mana pun, dan ini sudah menjadi tradisi sejak dahulu kala. Dalam kajian ini meditasi perspektif tasawuf hadir sebagai metode untuk meningkatkan transformasi kebahagiaan yang sejati. Meditasi menurut agama Buddha memiliki esensi yang sama dengan ritual praktik yang ada dalam agama Islam, hanya saja istilah yang digunakan beragam. Dalam tasawuf, meditasi mempunyai padanan kata dengan istilah yang disebut dalam agama Islam, yaitu Dzikir, tafakkur, mujahadah, muraqobah, riyadhah, dan uzlah. Selain itu, juga dibahas konsep kebahagiaan dari beberapa perspektif, seperti kebahagiaan perspektif psikologi barat, kebahagiaan perspektif sufistik, dan kebahagiaan menurut para ahli. Topik ini penulis jadikan sebagai kajian pembahasan guna mengeksplorasi lebih jauh bahwa Islam juga mempunyai metode meditasi dengan perspektifnya sendiri, dan meditasi berbasis sufistik ini sangat mendukung untuk meningkatkan transformasi spititualitas kita umumnya dan kebahagiaan khususnya.
Cost-effectiveness and budget impact of covering Burkitt’s Lymphoma in children under Ghana’s National Health Insurance Scheme
Authors: Owusu Richmond , Pritchard Dakota , Heupink Lieke Fleur , Gulbi Godwin , Asare Brian , Amankwah Ivy , Azeez Joycelyn , Gyansa-Lutterodt Martha , Dsane-Selby Lydia , Mensah Ruby Aileen , Omane-Agyekum William , Ruiz Francis , Gad Mohamed , Nonvignon Justice , Chola Lumbwe , Group Ghana HTA Technical Working 
Published: July 2023

Abstract

Background
Many children in sub-Saharan Africa die from preventable deaths due to Burkitt’s lymphoma (BL), an aggressive but highly curable form of non-Hodgkin’s lymphoma. Delayed care seeking and treatment abandonment are common reasons for a relatively low overall survival (OS) in low-and middle-income countries when compared to OS in high income settings. The financial burden of care seeking to families is often the main reason for the high treatment abandonment. Yet childhood cancer is not a high priority in health care financing for many countries, including in Ghana, where at the time of this study, treatment was not covered by the National Health Insurance Scheme (NHIS). In this study, we analyze the cost-effectiveness of extending health insurance coverage to children with BL in Ghana.
Methods
We developed a Markov model in Microsoft Excel to estimate the costs and effects of BL treatment when NHIS was provided compared to the status quo where NHIS does not cover care for childhood cancer. The analysis was undertaken from the societal perspective. Both costs (measured in $) and effects, measured using disability adjusted life years (DALYs), were discounted at a rate of 3%. The time horizon was a lifetime. Probabilistic sensitivity analysis was done to assess uncertainty in the measurement of the incremental cost-effectiveness ratio (ICER). A budget impact analysis was undertaken from the perspective of the NHIS.
Results
In the base-case analysis, the intervention (NHIS reimbursed treatment) was less costly than current practice ($8,302 vs $9,558). The intervention was also more effective with less DALYs per patient than the standard of care (17.6 vs 23.33). The ICER was $219 and indicates that intervention is still cost-effective when taking a narrower, health system only perspective. The probabilistic sensitivity analysis showed that the intervention is likely to be both less costly and more effective than current practice in 100% of the 1,000 simulations undertaken.
Conclusion
Providing health insurance coverage to children with BL is potentially highly cost-effective. The effectiveness and cost-savings relating to this strategy is driven by its positive impact on treatment initiation and retention. Based on this evidence, there has been a policy change where Ghana’s NHIS has prioritized financing for cancer treatment in children.
Improving Pain, Function and Quality of Life in End-Stage Knee Osteoarthritis: A Prospective Cohort Study of Whole-Body Vibration and Exercise as Bridging Therapies for Total Knee Replacement
Authors: Choi Kendrew Yu-Hei , Chau Wai-Wang , Li Linda Man-Kuen , Ng Sammie Yuk-Lam , Lo Boie Po-Yee , Ong Michael Tim-Yun , Yung Patrick Shu-Hang 
Published: July 2023

Abstract
Introduction: We prospectively evaluated the effects of exercise and whole-body vibration (WBV) on pain and function in 517 patients with end-stage knee osteoarthritis awaiting total knee replacement (TKR).
Methods: Participants were allocated to control (n=201), supervised physiotherapist-led exercise (n=227), or exercise + WBV (n=89) groups. The exercise and exercise + WBV groups completed 4 to 5 group exercise sessions and individualized home exercises. The exercise + WBV group also received 10 minutes of WBV with each session. Outcome measures included pain, self-reported physical function, range of motion, gait, and functional tests.
Results: Both exercise groups showed significant improvements in pain, Knee Society Score, knee function, Timed Up and Go test, and functional reach. The exercise + WBV group showed greater improvements in the Knee Injury and Osteoarthritis Outcome Score (KOOS) and KOOS subscales of Pain, Symptoms, and Quality of Life compared to exercise alone.
Discussion and Conclusion: Exercise and WBV may substantially improve pain and function for patients awaiting TKR. Targeted, optimized programs could help address needs during prolonged surgical waits and merit investigation. The potential benefits of WBV, including improved pain, symptoms, and quality of life, warrant further study to determine long-term impact and cost-effectiveness. This could support implementing effective approaches to alleviate the impact of delays for TKR. For patients with end-stage knee osteoarthritis awaiting surgery, supervised exercise therapy, especially with WBV, shows promise for reducing pain and improving function. This could bridge a critical gap for those experiencing prolonged waits for TKR.