bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical approaches to maintaining sinus rhythm in patients with type 2 diabetes and long-term persistent atrial fibrillation
Authors: Khamnagadaev I. A. , Zotov A. S. , Shelest O. O. , Bulavina I. A. , Glupak A. A. , Zotova Z. A. , Sakharov E. R. , Bondarenko I. Z. , Shatskaya O. A. , Habazov R. I. , Troitsky A. V. , Mokrysheva N. G. 
Published: February 2025

BACKGROUND: Treatment of patients with diabetes mellitus (DM) and a long-term persistent form of atrial fibrillation (AF) is an unsolved problem of the healthcare system due to a high risk of disability and mortality. Considering low effectiveness of drug treatment for AF, surgical technologies have been introduced into clinical practice in most countries, but their effectiveness has not been validated for patients with DM. According to various researches isolated interventional treatment of patients with AF and DM is associated with a high rate of recurrence compared to patients without disorders of carbohydrate metabolism. The feasibility of using other surgical approaches (the isolated thoracoscopic procedure or the isolated thoracoscopic procedure in combination with intracardiac intervention) for the treatment of AF for patients with DM has not been determined yet.AIM: To evaluate the effectiveness and safety of a staged surgical approach to release patients with DM from AF.MATERIALS AND METHODS: The study included 19 patients aged 53–73 with DM and long persistent AF. Among them there were 4 (21,4%) women and 15 (78,9%) men. To maintain sinus rhythm all patients were undergone with thoracoscopic epicardial ablation. In three mounts, later the invasive electrophysiological studies and radiofrequency ablation were carried out due to reconnection of left atrium (LA).RESULTS: At the end of the blinded period sinus rhythm was maintained for 17 (89,5%) patients during the observation period. Two patients (10.5%) had AF recurrence. In both cases, the second stage of treatment wasperformed (electrophysiology study and endocardial ablation). Amid normal sinus rhythm after thoracoscopic epicardial ablation the volume of the LA (p=0,013) and the N-terminal prohormone of brain natriuretic peptide (NT-proBNP) (p=0,014) significant decreased. No adverse events were recorded in the perioperative or long-term periods.CONCLUSION: Аccording to our pilot study, the staged approach to surgical maintenance of sinus rhythm for patients with diabetes and persistent form of atrial fibrillation can be an optimal strategy. The endocardial stage could be performed for this category of patients in case of recurrence of tachysystolic cardiac arrhythmias.
Normalized solutions for nonlinear Schrödinger systems with critical exponents
Authors: Hu Jiaqing , Mao Anmin 
Published: February 2025

Abstract
In this paper, we consider the following nonlocal Schrödinger system

−

a
+
b

∫

R

3

|
∇

u

1

|

2

d
x

Δ

u

1

=

λ

1

u

1

+

μ

1

|

u

1

|

p

1

−
2

u

1

+
β

r

1

|

u

1

|

r

1

−
2

u

1

|

u

2

|

r

2

,

−

a
+
b

∫

R

3

|
∇

u

2

|

2

d
x

Δ

u

2

=

λ

2

u

2

+

μ

2

|

u

2

|

p

2

−
2

u

2

+
β

r

2

|

u

1

|

r

1

|

u

2

|

r

2

−
2

u

2

,

∫

R

3

|

u

1

|

2

d
x
=

c

1

,

∫

R

3

|

u

2

|

2

d
x
=

c

2

.

$$\begin{cases}-\left(a+b{\int }_{{\mathbb{R}}^{3}}\vert \nabla {u}_{1}{\vert }^{2}\mathrm{d}x\right){\Delta}{u}_{1}={\lambda }_{1}{u}_{1}+{\mu }_{1}\vert {u}_{1}{\vert }^{{p}_{1}-2}{u}_{1}+\beta {r}_{1}\vert {u}_{1}{\vert }^{{r}_{1}-2}{u}_{1}\vert {u}_{2}{\vert }^{{r}_{2}},\quad \hfill \\ -\left(a+b{\int }_{{\mathbb{R}}^{3}}\vert \nabla {u}_{2}{\vert }^{2}\mathrm{d}x\right){\Delta}{u}_{2}={\lambda }_{2}{u}_{2}+{\mu }_{2}\vert {u}_{2}{\vert }^{{p}_{2}-2}{u}_{2}+\beta {r}_{2}\vert {u}_{1}{\vert }^{{r}_{1}}\vert {u}_{2}{\vert }^{{r}_{2}-2}{u}_{2},\quad \hfill \\ {\int }_{{\mathbb{R}}^{3}}\vert {u}_{1}{\vert }^{2}\mathrm{d}x={c}_{1}, {\int }_{{\mathbb{R}}^{3}}\vert {u}_{2}{\vert }^{2}\mathrm{d}x={c}_{2}.\quad \hfill \end{cases}$$

In the case of b = 0, 2 < p
1, p
2 < 2*, the existence of a Mountain Pass solution and a global minimizer to the above problem was obtained (see T. Bartsch, L. Jeanjean [Proc. R. Soc. Edinburgh, Sect. A, 148 (2018), pp. 225–242.]). However, in the case of b > 0, p
1 = p
2 = 2*,

2
<

r

1

+

r

2

<

p

̂

$2{< }{r}_{1}+{r}_{2}{< }\hat{p}$

or

p

̄

≤

r

1

+

r

2

<

2

*

$\bar{p}\le {r}_{1}+{r}_{2}{< }{2}^{{\ast}}$

, similar existence results to the above problem is still unknown, here 2* is Sobolev critical exponent and

p

̂

=

10

3

$\hat{p}=\frac{10}{3}$

,

p

̄

=

14

3

$\bar{p}=\frac{14}{3}$

are the L
2-critical exponent for the system when b = 0 and b > 0 respectively. Here we focus on these unknown case. We investigate the existence of positive normalized solutions under different assumptions on β > 0. Figure 1, Tables 1 and 2 will illustrate our main results and the relationship between our work and some related works in the literature.
Copy number variation sequencing detection technology for identifying fetuses with abnormal soft indicators: a comprehensive study
Authors: Lu Guangting , Liu Weiwu 
Published: February 2025

Abstract

Objectives
This study aims to assess the value of copy number variation sequencing (CNV-seq) in prenatal diagnosis of abnormal ultrasound markers to reduce fetal birth defects.

Methods
Between June 2021 and December 2022, Yulin Maternal and Child Health Care Hospital examined 295 pregnant women with abnormal ultrasound indicators. We were categorized by the number of abnormalities and age. Karyotype analysis and CNV-seq were conducted, and the CNV-seq detection rate was statistically analyzed.

Results
CNV-seq detected abnormal chromosomes in 43 out of 295 pregnant women with abnormal fetal ultrasound soft indicators, resulting in a detection rate of 14.58 %, compared to 5.76 % with traditional karyotype analysis. CNV-seq identified all aneuploidy abnormalities found by karyotype analysis and an additional 5 abnormalities, increasing the detection rate by 1.69 %. However, CNV-seq missed one case of chromosome equilibrium translocation. The detection rate of CNV-seq in fetuses with Several abnormal soft indexes was 29.41 %, significantly higher than individual soft indexes (p<0.05). The study compared abnormality rates of single and multiple ultrasound soft markers in two age groups. Abnormal detection rates were 12.38 % for the younger group and 13.73 % for the older group, with no significant difference. However, the younger group had a significantly higher detection rate for multiple soft markers compared to the older group (χ2=5.517, p<0.05).

Conclusions
CNV-seq technology is valuable for identifying fetuses with abnormal soft markers, guiding its future use in perinatal diagnosis and aiding clinical genetic counseling.
Direct Hydroxylation of Benzene to Phenol over Vanadium Oxide Supported on Carbon Fibers Felt Containing Nitrogen
Authors: Javadi Maryam Sadat , Ghiaci Mehran , Mahdavi Mohammad , Bahadorikhalili Saeed 
Published: February 2025

Abstract

Direct hydroxylation of benzene is a stable and promising strategy for phenol synthesis. In this project, VO (12.5 wt%)/N-CFF catalyst was synthesized by VO-nitrogen doped carbon and supported on carbon fibers felt simultaneously. The synthesized catalyst was characterized by XPS, BET, FESEM, EDX-mapping, XRD, TEM, TGA, Raman, FT-IR, UV-Vis, ICP analysis. catalytic performance of VO (12.5 wt%)/N-CFF was also investigated in both thermal and photocatalytic oxidation reactions of benzene to phenol under optimal conditions. The selectivity of 100% was obtained. The yield of phenol product in thermal oxidation and photocatalytic oxidation of benzene were 18.9 and 16.82 respectively. In these reactions acetonitrile was used as solvent and hydrogen peroxide was used as oxidant. Optimal conditions for thermal oxidation of benzene, 50 mg catalyst, 80°C temperature, 6 h time, molar ratio of H2O2/Benzene 2, were obtained. The reaction was performed under 5 bar N2 pressure. Optimal conditions for photocatalytic oxidation of benzene, 50 mg catalyst, 65°C temperature, 4 h time, molar ratio of H2O2/Benzene 2 and distance of visible light to reaction dish 20 cm were obtained. The synthesized catalyst is a bulk catalyst based on eco-friendly support with high performance and recyclability and easy separation of reaction.
Morphological, Anatomical, and Phytochemical Evaluation of Cissusquadrangularis I, Cissus quadrangularis II, Cissus rotundifoila and Cissus cactiformis
Authors: Mohan Sangeetha 
Published: February 2025

Abstract

These Medicinal plants collected from Tamil Nadu have very distinct and tedious external morphological features which could lead to chaos. To validate its taxonomy, anatomical structures, and phytochemical components are evaluated. Cissus rotundifolia, Cissus quadrangularis, and Cissus cactiformis are some of the abundantly available but less researched medicinal plants in Tamil Nadu, India. Numerous studies have been performed worldwide to describe the anatomical characteristics of the stem of the Cissus species. The selected Cissus species are from belong to the Vitaceae family and exhibit four distinct morphological variants. These variants differ significantly in their morphological and anatomical characteristics. According to the results of an external feature study, the stem of Cissus quadrangularis I is dark green in colour with quadrangular sides. Cissus quadrangularis II has a pale green stem with triangular, flat edges. The dark green stem of Cissus cactiformis features quadrangular sides with a serrated edge. These three Cissusvariations are stem-type variations, and their stems differ noticeably in appearance. Cissus rotundifoila, on the other hand, is a leaf-type variation. The microscope features analysis revealed a distinct difference in these plant varieties, such as vascular bundles, a layer of parenchymatous, collenchymatous, sclerenchymatous, phloem cells, and xylem vessel rows evident under the microscope feature of the transfer section. These features exhibit notable variations in each variant. The identification of four Cissus variations is made easier by this microscopic and exterior investigation. Additionally, the results of the GCMS analysis revealed the various new phytochemical elements. In conclusion, the four Cissus species under study have unique morphological features and phytochemical contents, and their conflict has unique medicinal qualities that are verified to identify the phytochemical investigations.
Development of Tissue Culture Techniques and Comparative Metabolomics for Echeveria laui Calli
Authors: Fu Shuangbin , Ying Zhen , Chen Chaoxiang , Yang Yanping 
Published: February 2025

Abstract

In recent years, the market for succulent plants has experienced rapid growth. To increase the yield and value of Echeveria laui, a member of the succulent family, a tissue culture method was established in this study. The highest callus induction rate (26.7%) was achieved on Murashige and Skoog (MS) medium supplemented with 3 mg·L−1 6-benzylaminopurine (6-BA), 1 mg·L−1 α-naphthaleneacetic acid (NAA), and 0.1 mg·L−1 thidiazuron (TDZ). The highest proliferation coefficient (4.26) was observed on medium containing 3 mg·L−1 6-BA and 1 mg·L−1 NAA. Seedlings were regenerated when calli were cultured on MS or 1/2 MS medium without plant growth regulators (PGRs). During proliferation, three distinct types of calli were identified and analyzed using morphological observations and widely targeted metabolomics. Morphological analysis revealed that regenerable calli (GCs) presented numerous granular buds on their surface, and the cells were regular and complete, contributing to their regenerability. Metabolomic analysis revealed that the differentially accumulated metabolites (DAMs) were primarily amino acids and their derivatives, with dUMP identified as a biomarker for dis- tinguishing among the three callus types. Additionally, changes in phytohormone levels were observed across the different callus types. These findings provide a valuable reference for optimizing culture systems, minimizing undesirable tissue changes, and enhancing propagation efficiency.
In Silico Study of Argan Oil Metabolites: Evaluation of Their Potential to Inhibit Key Receptors Activated by Excessive Alcohol Consumption and Involved in Cell Death
Authors: Bekkouch Ayoub , Bekkouch Oussama , Ziani Anas , Bentouhami Nour E. , Abouyaala Oumaima , marouane marouane El arbaoui , mostafi hicham el , Hamzaoui abdelghafour , Hesni Aboubaker el , Mesfioui Abdelhalem 
Published: February 2025

Abstract

Excessive alcohol consumption is a well-established cause of liver injury and neurodegeneration, driven by oxidative stress, inflammation, and apoptosis. This study explores the potential of Argania spinosa (argan oil) metabolites as natural inhibitors of key receptors involved in alcohol-induced cellular damage: NOX4 (NADPH Oxidase 4), PARP (Poly ADP-ribose Polymerase), and CCR2 (C-C Motif Chemokine Receptor 2). Using in silico approaches, including molecular docking, ADMET analysis, and molecular dynamics simulations, we systematically evaluated the interactions between twenty previously reported argan oil metabolites and these receptors.
Among the analyzed compounds, spinasterol emerged as the most promising bioactive molecule, demonstrating high binding affinity and structural stability within the receptor active sites. Molecular interaction analysis revealed strong hydrophobic interactions, π-π stacking, and hydrogen bonding, contributing to receptor inhibition. These findings suggest that spinasterol could modulate inflammatory and oxidative pathways, reducing alcohol-induced cellular stress.
This study underscores the potential of argan oil metabolites as natural therapeutic agents for preventing and mitigating alcohol-related pathologies. Future in vitro and in vivo investigations are necessary to validate these computational results and explore the translational potential of these compounds in clinical settings. The findings contribute to advancing plant-based drug discovery and natural pharmacological interventions for alcohol-induced disorders.
Recovery of Au(III) from electronic waste using solid phase extraction based on a magetic nanobiocomposite, OCBS@Fe3O4 @UiO-66-SH
Authors: Poormoghadam Parisa , Bahar Soleiman , Naghdi Yunes 
Published: February 2025

Abstract

This study created a zirconium-based MOF (UiO-66-NH2) with thiol groups attached to its magnetic corn surface for adsorption and extraction of Au(III) from electronic waste. Characterization of the composite was verified using FTIR, XRD, FESEM, TGA and BET techniques. The temperature, adsorption period, and pH on Au(III) adsorption were investigated. The pH of solutions significantly impacts Au(III) adsorption, with pH 6.0 being the optimal value. The optimum Au(III) adsorption conditions were 50 ◦C, 40 min, and 10 mg of adsorbent. Moreover, functionalized oxidized magnetic corncobs with thiol (OCBS@Fe3O4@UiO-66-SH) showed a notable ability to adsorb Au(III) with a 1587 mg/g capacity. With mass ratios of Au(III) to competing ions (Mg, Mn, Cu, Zn, Co, Cd, and Ni) fixed at 1:1 or extended to 1:5, this adsorbent prefers Au(III) ions while showing negligible adsorption to other ions. The study validated a technique for extracting Au(III) from various electronic waste samples, achieving high recovery rates (95.30–104.75%), demonstrating its effectiveness and lack of matrix interference. Langmuir, Freundlich, and Temkin isotherm models were used to describe the adsorption process. Comparing models, the Langmuir model with the most excellent R2 value is best for interpreting experimental adsorption data. Among three kinetic models, pseudo-first-order (PFO), pseudo-second-order (PSO) kinetic, and interparticle diffusion (ID) models, PFO model exhibited a high R2 value (0.9976). Thermodynamic calculations reveal a positive ΔH°, indicating the endothermic process, and negative ΔG° values representing spontaneous adsorption at 298–323 K. The positive ΔS° shows that the adsorbed molecules are more uniformly dispersed on the surface, potentially enhancing the adsorption capacity.
The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin
Authors: Akan Ezgi , Sakıncı Mehmet , Suleymanlar Gultekin , Korgun Emin Türkay , Kipmen-Korgun Dijle 
Published: February 2025

Abstract

Purpose
Chronic glomerular and tubulointerstitial fibrosis is the leading cause of end-stage renal failure. Mesenchymal stem cell therapy shows great potential for kidney tissue regeneration. The use of measurable biomarkers is crucial for assessing the therapeutic effects of mesenchymal stem cells. Adiponectin is among the suggested biomarkers for monitoring the progression of chronic renal failure.
Methods
We extracted mesenchymal stem cells from the amnion membrane of term placentas. To establish the experimental groups, we partially ligated the left kidneys of male Wistar rats, fully removed the right kidney after two weeks, and observed them for an additional eight weeks. At the end of this period, the animals underwent a subtotal nephrectomy. After forming 5/6 nephrectomy, we transplanted stem cells via rat tail vein and waited for 15 and 30 days to form stem cell groups. We measured protein levels and mRNA expressions of Adiponectin, Adiponectin Receptor 1, Fibronectin and AMPK phosphorylation by western blot and Real-Time PCR methods respectively. Besides, urine and serum levels of adiponectin and urine levels of albumin measured by using a rat specific ELISA.
Results
Protein and mRNA expressions of Adiponectin, AdipoR1, Fibronectin, and AMPK phosphorylation were elevated in the nephrectomy groups compared to the controls; however, these increased gene and protein expressions declined following stem cell administration.
Conclusion
mesenchymal stem cells may have a therapeutic effect on chronic renal failure, and adiponectin may serve as a biomarker for monitoring disease progression.
A Review of Anticancer Activity of Ferula Constituents and their Action Mechanism
Authors: Zare-Bidoki Reza , Afrasiabi Ali , Hajatmand-Targhi Fatemeh Zahra , Rahimi Hossein , Bagheri Seyyed Majid 
Published: February 2025

Background:
Cancer is a challenging and lethal illness, with the number of individuals affected on
the rise, particularly in developing nations. This disease incurs significant expenses for both patients and governments
annually. Conversely, even with various methods and treatments in use, the mortality rate remains elevated.
Additionally, traditional therapies come with numerous side effects, and drug resistance presents
another obstacle for physicians. Consequently, discovering new drugs derived from natural sources may be a
method to combat cancer. Ferula plants contain different metabolites, including monoterpenes, sulfide compounds,
and polyphenols that are beneficial in cancer therapy.

Objective:
This article was assembled to gather evidence and literature concerning the anti-cancer properties
of compounds derived from these plants.

Methodology:
This review article was created by exploring the term Ferula isolated constituents and cancer,
with related data gathered from electronic databases such as ISI Web of Knowledge, PubMed, and Google
Scholar up until early 2024.

Results:
Results revealed that quite extensive research has been done in this area, indicating that the compounds
may serve as novel medications for cancer therapy.

Conclusion:
Subsequent research should encompass animal studies or clinical trials, focusing on assessing
toxicity and identifying effective doses against cancer to facilitate the application of these natural derivatives
in cancer treatment.
Amyloid-β Clearance with Monoclonal Antibodies: Transforming Alzheimer’s Treatment
Authors: Fatima Rabab , Khan Yumna , Maqbool Mudasir , Ramalingam Prasanna Srinivasan , Khan Mohammad Gayoor , Bisht Ajay Singh , Hussain Md Sadique 
Published: February 2025

Abstract:
Alzheimer's disease (AD) is a progressive condition that causes the degeneration of
nerve cells, leading to a decline in cognitive abilities and memory impairment, significantly affecting
millions around the globe. The primary pathological feature of AD is the buildup of amyloid-β
(Aβ) plaques in the brain, which has become a major target for therapeutic strategies. This thorough
review examines the progress made in next-generation therapies that concentrate on monoclonal
antibodies (mAbs) aimed at Aβ. We explore how these antibodies function, their effectiveness
in clinical settings, and their safety profiles, specifically discussing notable mAbs, such as aducanumab,
donanemab, lecanemab, etc. This review also addresses the difficulties related to Aβ--
targeted treatments. Furthermore, it examines the advancing field of biomarker development and
tailored medicine strategies designed to improve the accuracy of AD treatment. By integrating the
latest findings from clinical trials and new research, this review offers an in-depth evaluation of
the possibilities and challenges associated with mAbs in modifying the progression of AD. Future
considerations regarding combination therapies and novel drug delivery methods are also examined,
emphasizing the necessity for ongoing research to achieve significant advancements in
managing AD. Through this review, we seek to provide clinicians, researchers, and policymakers
with insights into the current landscape and future directions of Aβ-targeted therapies, promoting
a deeper understanding of their role in addressing AD.
Antibacterial, Antibiotic-Potentiating, and Antiviral Activities of Selected Endemic Primary Rainforest Plants of Peninsular Malaysia
Authors: Zulkipli Masyitah , Sulaiman Mazdida , Elbehairy Layane , Jin Khoo Teng , Abdullah Nor Hayati , Raju Chandramathi Samudi , Kathirvalu Gheetanjali , Nissapatorn Veeranoot , Rusdi Nor Azizun , Saikim Fiffy Hanisdah , Zarubaev Vladimir , Rafon John Kenny , Villegas Jhonnel , Wiart Christophe 
Published: February 2025

Background:
There is a need to identify original molecules to develop drugs for the
treatment of microbial infections. Such chemical entities could be found in secondary metabolites
of rainforest plants that are not so well-known. This study examines the antibacterial and antibiotic-
potentiating effects, and antiviral activities of six rainforest plants endemic to the primary
rainforest of Malaysia.

Methods:
Leaves, bark, fruits, and wood of Burkillanthus malaccensis, Cleistanthus bracteosus,
Diospyros hasseltii, Kibatalia maingayi, Knema retusa, and Litsea spathacea were extracted successively
with hexane, chloroform, and methanol, and tested against six human pathogenic bacteria
species by disc diffusion and broth microdilution. The extracts were tested against influenza
virus A/Puerto Rico/8/34 (H1N1) using MDCK cells.

Results:
Of the 42 extracts tested, the hexane extract of fruits of D. hasseltii inhibited the growth
of E. coli with the MIC value of 39 μg/mL. The chloroform extract of leaves of C. bracetosus potentiated
the activity of levofloxacin against P. aeruginosa. The strongest antiviral activity was observed
with the chloroform extract of leaves of C. bracteosus with the IC50 value of 6.3 μg/mL.
The chloroform extract of bark of B. malaccensis with the IC50 value of 0.6 μg/mL was the most
cytotoxic.

Conclusion:
Preserving the primary rainforest of Malaysia is a means to preserve natural products
with the ability to be developed as antimicrobial leads. In particular, D. hasseltii, C. bracteosus,
and B. malaccensis could be examined for their active antimicrobial constituents.