bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catalytic Nucleophilic and Electrophilic Functionalization of Dihydroquinoxalin‐2‐ones
Authors: Rostoll‐Berenguer Jaume , Blay Gonzalo , Pedro José R. , Vila Carlos 
Published: March 2023

AbstractFinancial support from grant PID2020‐116944GB funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe” and CIAICO/2021/147 funded by Conselleria d'Innovació, Universitat, Ciència i Societat Digital is acknowledged. J.R.‐B. thanks the Ministerio de Ciencia, Innovación y Universidades for a FPU predoctoral contract (FPU17/00688). C.V. thanks the RyC contract (RYC‐2016‐20187) funded by MCIN/AEI/10.13039/501100011033 and by “European Union NextGeneration EU/PRTR”. Access to NMR, MS, and X‐ray facilities from the Servei Central de Suport a la Investigació Experimental (SCSIE)‐UV is also acknowledged.
Association between major discrimination and deficit accumulation in African American cancer survivors: The Detroit Research on Cancer Survivors Study
Authors: Mandelblatt Jeanne S. , Ruterbusch Julie J. , Thompson Hayley S. , Zhou Xingtao , Bethea Traci N. , Adams‐Campbell Lucile , Purrington Kristen , Schwartz Ann G. 
Published: March 2023

AbstractBackgroundDiscrimination can adversely affect health and accelerate aging, but little is known about these relationships in cancer survivors. This study examines associations of discrimination and aging among self‐identified African American survivors.MethodsA population‐based sample of 2232 survivors 20–79 years old at diagnosis were enrolled within 5 years of breast (n = 787), colorectal (n = 227), lung (n = 223), or prostate (n = 995) cancer between 2017 and 2022. Surveys were completed post‐active therapy. A deficit accumulation index measured aging‐related disease and function (score range, 0–1, where <0.20 is robust, 0.20 to <0.35 is pre‐frail, and 0.35+ is frail; 0.06 is a large clinically meaningful difference). The discrimination scale assessed ever experiencing major discrimination and seven types of events (score, 0–7). Linear regression tested the association of discrimination and deficit accumulation, controlling for age, time from diagnosis, cancer type, stage and therapy, and sociodemographic variables.ResultsSurvivors were an average of 62 years old (SD, 9.6), 63.2% reported ever experiencing major discrimination, with an average of 2.4 (SD, 1.7) types of discrimination events. Only 24.4% had deficit accumulation scores considered robust (mean score, 0.30 [SD, 0.13]). Among those who reported ever experiencing major discrimination, survivors with four to seven types of discrimination events (vs. 0–1) had a large, clinically meaningful increase in adjusted deficits (0.062, p < .001) and this pattern was consistent across cancer types.ConclusionAfrican American cancer survivors have high deficit accumulated index scores, and experiences of major discrimination were positively associated with these deficits. Future studies are needed to understand the intersectionality between aging, discrimination, and cancer survivorship among diverse populations.
Adsorption‐Assisted Redox Center in Porous Organic Frameworks for Boosting Lithium Storage
Authors: Xie Huanyu , Li Pai , Xie Shuai , Jin Hongchang , Jin Song , Kong Xianghua , Li Zhenyu , Ji Hengxing 
Published: March 2023

AbstractDue to the designable structure and capacity, organic materials are promising candidates for lithium‐ion batteries. Herein, we report a novel type of porous organic frameworks (POFs) based on the coupling reaction of diazonium salt as the anodes for lithium ion storage. The active center containing an azo group and the adjacent lithium‐philic adsorption site is constructed to investigate the electrochemical behaviors and reaction mechanism. As synthesized POF material (named as POF‐AN) exhibits high reversible lithium storage capacities of 523 mAh g−1 at 0.5 A g−1 and 445 mAh g−1 at 2.0 A g−1 after 1500 cycles, showing excellent cycle stability and rate performance. The detailed characterizations reveal that the azo group can act as an electrochemical active site that reversibly bonds with Li‐ions, and the adjacent oxygen atoms can electrostatically adsorb with Li‐ions to promote the lithium storage reaction. This adsorption‐assisted three‐atom redox center is beneficial to synergistically enhance the adsorption and intercalation of lithium ions, which can further improve the capacity and cycle stability. By replacing the precursor, it is also facile to synthesize more similar structure types. The reversible redox chemistry of the adsorption‐assisted three‐atom active center provides new opportunities for the development of long lifespan and high‐rate organic anodes.
Video games as a tool for ecological learning: the case of Animal Crossing
Authors: Coroller S. , Flinois C. 
Published: March 2023

AbstractAmidst lockdown policies in response to the COVID‐19 pandemic, many used video games as a method to maintain a connection with others while ensuring social distancing. A new edition of the Animal Crossing series of games had been released in March 2020 and beat sales and downloads records. The game focuses on living in a natural environment, building a house and a village, as well as capturing, exhibiting, and selling species to progress. Here we examine whether players gain species identification skills and whether it is transferred to real‐life models. We used the results from a survey conducted from the end of March to early April 2020 on 200 people (72 players and 128 nonplayers of Animal Crossing). Participants were first asked to rank their personal interest in nature and then to identify species from photos. The photos displayed both organisms present in the game and organisms that were not. We expected players to obtain a slightly higher score than nonplayers for questions related to the species present in the game and a similar score in both groups for questions related to species not present in the game. Multivariate analyses (multiple linear regression and principal components analysis [PCA]) showed that players were better than nonplayers at identifying real‐life species that were present in the game. The role of the species in the game design impacts the ability to identify the species in real life, such as plants having mainly a role of ornamentation. Additionally, this study suggests that survey participants could correctly assess their naturalistic knowledge in general. This article shows that video games can help enhance ecological learning, improve organisms identification, and might be used as a tool for education in conservation biology.
Generalized stacked LSTM for the seismic damage evaluation of ductile reinforced concrete buildings
Authors: Ahmed Bilal , Mangalathu Sujith , Jeon Jong‐Su 
Published: March 2023

AbstractTo organize accurate and effective emergency responses after an earthquake, it is vital to conduct an early and precise assessment of damage to structures. The use of fragility/vulnerability curves is an advanced evaluation approach for structural damage assessments. However, the analysis based on fragility curves significantly varies depending on soil conditions, ground motion, and structural characteristics. To overcome this issue, a stacked long short‐term memory network was proposed in this research. Unlike previous studies, two input features (acceleration time history in the form of vector and the number of stories in the scalar) are utilized to generalize the results for the same plan building frames with different stories. Three different approaches are presented in this work to link the ground motion time history with the number of stories (2, 4, 8, 12, and 20 stories) in the reinforced concrete building frame, and the networks were tested for unknown ground motions. Of the three approaches, those providing good results were selected for further analysis. For the approaches chosen, the network architectures were changed to a diamond shape and an autoencoder‐like shape with more hidden units (to obtain higher accuracy), which were tested for unknown same plan layout frames. The accuracy obtained using these approaches was significantly high (80%–90%) with a low training time. The proposed model is compared with other techniques and shows significant accuracy. The suggested networks exhibited a number of scenarios for estimating the damage state for unknown ground motions, as well as for unknown frames with various stories. Moreover, the capability of the networks to handle more scalar input features is examined by adding them probabilistically; with additional input variables, the networks predicted the damage state with higher accuracy.
Cost-Effective Pharmaceutical Implants in Fish: Validating the Performance of Slow-Release Implants for the Antidepressant Fluoxetine
Authors: McCallum Erin S. , Cerveny Daniel , Bose Aneesh P. H. , Fick Jerker , Brodin Tomas 
Published: March 2023

Abstract
Internal, slow-release implants can be an effective way to manipulate animal physiology or deliver a chemical exposure over long periods of time without the need for an exogenous exposure route. Slow-release implants involve dissolving a compound in a lipid-based carrier, which is inserted into the body of an organism. However, the release kinetics of the compound from the implant to body tissues also requires careful validation. We tested and validated a slow-release implant methodology for exposing fish to a pharmaceutical pollutant, fluoxetine. We tested two lipid-based carriers (coconut oil or vegetable shortening) in the common roach (Rutilus rutilus). The implants contained either a high (50 μg/g), low (25 μg/g), or control (0 μg/g) concentration of fluoxetine, and we measured tissue uptake in the brain, muscle, and plasma of implanted fish over 25 days. The two carriers released fluoxetine differently over time: coconut oil released fluoxetine in an accelerating manner (tissue uptake displayed a positive quadratic curvature), whereas vegetable shortening released fluoxetine in a decelerating manner (a negative quadratic curvature). For both carrier types, fluoxetine was measured at the highest concentration in the brain, followed by muscle and plasma. By comparing the implant exposures with waterborne exposures in the published literature, we showed that the implants delivered an internal exposure that would be similar if fish were exposed in surface waters containing effluents. Overall, we showed that slow-release internal implants are an effective method for delivering chronic exposures of fluoxetine over at least 1-month time scales. Internal exposures can be an especially powerful experimental tool when coupled with field-based study designs to assess the impacts of pharmaceutical pollutants in complex natural environments. Environ Toxicol Chem 2023;42:1326–1336. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
A Study of Headspace Solid-Phase Microextraction in the Analysis of 54 Hydrophobic Pollutants in Remote Alpine Lake Waters with an Emphasis on Analyte Recovery and Storage Time
Authors: Tillman Joseph M. , Weckel-Dahman Will , Mullins Peter C. L. , Phan Phi V. , Doyle Emily , James Nicole M. , Conroy Nathan A. , Dunnivant Frank M. 
Published: March 2023

Abstract
Commercially available headspace solid-phase microextraction (HS-SPME) fibers have been used for years to extract pesticides and polychlorinated biphenyls from aqueous samples at the expected ultratrace levels (picograms per liter or parts per quadrillion) in alpine lakes. Several variables of the HS-SPME technique have been adequately evaluated, including water temperature, pH, salt content, fiber type and coating thickness, length of fiber-sample exposure, and liquid immersion versus headspace exposure; but surprisingly, analyte recovery as a function of analyte concentration and storage time has not been included in previous studies, which can be important for remote sampling sites. Seven hydrophobic chlorinated pollutants were identified in alpine lake water (out of 54 analyzed); but recovery using the common SPME technique was found to be inconsistent as the analyte concentration decreases, and the recovery trend as a function of concentration varies on a compound-to-compound basis that could result in a large underestimation of analyte concentrations in field samples. Of the 54 compounds surveyed, o,p′-dichlorodiphenyltrichloroethane (DDT), p,p′-DDT, p,p′-dichlorodiphenyldichloroethylene (DDE), o,p′-DDE, chlorthal-dimethyl, endosulfan I, γ-hexachlorocyclohexane, heptachlor, and trans-nonachlor were generally measured at concentrations between 1 and 150 pg/L (parts per quadrillion). No study to date has evaluated this commonly used but unstandardized technique for analyte recovery as a function of analyte concentration or storage time of aqueous samples. Environ Toxicol Chem 2023;42:1199–1211. © 2023 SETAC
Highly Selective Aptamer‐Molecularly Imprinted Polymer Hybrids for Recognition of SARS‐CoV‐2 Spike Protein Variants
Authors: Sullivan Mark V. , Allabush Francia , Flynn Harriet , Balansethupathy Banushan , Reed Joseph A. , Barnes Edward T. , Robson Callum , O'Hara Phoebe , Milburn Laura J. , Bunka David , Tolley Arron , Mendes Paula M. , Tucker James H. R. , Turner Nicholas W. 
Published: March 2023

AbstractVirus recognition has been driven to the forefront of molecular recognition research due to the COVID‐19 pandemic. Development of highly sensitive recognition elements, both natural and synthetic is critical to facing such a global issue. However, as viruses mutate, it is possible for their recognition to wane through changes in the target substrate, which can lead to detection avoidance and increased false negatives. Likewise, the ability to detect specific variants is of great interest for clinical analysis of all viruses. Here, a hybrid aptamer‐molecularly imprinted polymer (aptaMIP), that maintains selective recognition for the spike protein template across various mutations, while improving performance over individual aptamer or MIP components (which themselves demonstrate excellent performance). The aptaMIP exhibits an equilibrium dissociation constant of 1.61 nM toward its template which matches or exceeds published examples of imprinting of the spike protein. The work here demonstrates that “fixing” the aptamer within a polymeric scaffold increases its capability to selectivity recognize its original target and points toward a methodology that will allow variant selective molecular recognition with exceptional affinity.
Evolution of the Paleo–Asian Ocean in south‐eastern Inner Mongolia, China: Evidence from zircon U–Pb ages, Hf isotopes data and specific deformation of the Linxi and Sunjiafen formations
Authors: Du Yuchun , Huang Fei , Liu Xing , Wang Yan , Wang Wencai 
Published: March 2023

The crystallization age of the Sunjiafen Formation volcanic rocks is 253.9 ± 1.1 Ma. Geochemical data show that these volcanic rocks belong to the shoshonitic and metaluminous series and have high Sr and low Y contents (461–582 and 5.60–6.74 ppm, respectively), MgO = 1.32–2.65 wt%, and Na2O/K2O = 0.81–1.40. In MgO−SiO2, Cr−SiO2, Sr/Y−Y and (La/Yb)N−YbN diagrams, data for the samples plot in the adakite and “adakite related to thickened lower crust” fields. As such, we suggest that the Sunjiafen Formation C−type adakitic andesites formed in a compressional tectonic setting. The youngest age (youngest peak age) of two sandstone samples from the Linxi Formation are 251 Ma (257 Ma) and 237 Ma (254 Ma). Detrital zircons with ages of >1500 Ma have εHf(t) values of −5.87 to +6.31. A comparison of the age spectra and εHf(t) values of the detrital zircons in the Linxi Formation with those of igneous zircons from the Central Asian Orogenic Belt and North China Craton indicates the formation was derived from both the belt and the craton. We identified “Jura–type Folds” that formed in peripheral foreland basin in the Linxi Formation, and along with plant fossil fragments (Paracalamites frigidus). These and previously published results indicate the Paleo–Asian Ocean closed along the Xar Moron–Changchun Suture zone during the Late Permian. The study area was in a continuous compressional setting during the Late Permian and formed a peripheral foreland basin that was related to continent–continent collision.
Effects of irrigation and nitrogen fertilizer management on wheat grain baking quality based on the SiriusQuality2 crop model
Authors: Liu Jianchao 
Published: March 2023

AbstractThe baking quality of wheat grain is significantly affected by irrigation and nitrogen fertilizer management. This study aimed to model the impacts of nitrogen and water stress on winter wheat grain protein composition using SiriusQuality2. SiriusQuality2 was calibrated by using sufficient nitrogen and water treatments and used to evaluate 16 treatments in semi‐arid regions. Then, simulated baking quality and yield over a past 51‐year period were used to screen and optimize the selected 203 management practices. The evaluated simulation results suggest that all relative root mean square errors were less than 0.3, and the simulation results were excellent or good. Irrigation and nitrogen fertilization were beneficial to yield and grain protein content (GPC), while grain baking quality had adverse responses to irrigation. The GPC no longer increased, and the baking quality decreased with excess nitrogen fertilization (262.5 kg ha−1). Increasing the irrigation frequency and days after sowing were always conducive to baking quality. The optimal management, with a basal dressing of 315‐kg ha−1 nitrogen fertilization and 180‐mm irrigation depth at the wintering stage and jointing stage, was selected. Optimized management practices could simultaneously meet the multiple requirements of high grain quality and yield.
Effects of the depth of the needle‐shaped water dispersion device inserted into the jet on the jet breakup of sprinklers
Authors: Pan Xuwei , Jiang Yue , Li Hong 
Published: March 2023

AbstractNeedle‐shaped water dispersion devices (NSWDDs) can break the jet and make the sprinkler spray evenly even under low working pressure. However, an inappropriate selection of the depth at which the NSWDD is inserted into the jet will affect the sprinkler pattern radius. To study the effect of the NSWDD insertion depth on the jet breakup, the jet structure, atomization, vorticity, static pressure and velocity distribution are studied using a combination of the lattice Boltzmann method and high‐speed photography. The results show that as the insertion depth increases, the jet structures gradually evolve from liquid films to ligaments, causing the diffusion angle of the jet to increase. Under the same operating pressure, the degree of jet atomization increases with increasing insertion depth. Meanwhile, the velocity pulsation degree on the central axis gradually increases, which will cause the jet to have a shorter air travelling distance. As the insertion depth and the radial position distance from the nozzle outlet increase, the velocity on the radial line first exhibits a symmetrical distribution, then an asymmetric one and finally a symmetric one again. The results can fill the gap in previous research on the effects of the NSWDD on jet breakup.
Barriers towards Open Government Data Value Co‐Creation: An empirical investigation
Authors: Wiedenhöft Guilherme Costa , Matheus Ricardo , Saxena Stuti , Alexopoulos Charalampos 
Published: March 2023

AbstractWhilst extant literature on Open Government Data (OGD) focuses upon value creation and innovation, there is scant emphasis upon the Value Co‐Creation (VCC) that might result with the engagement of the public sector agencies and the users at large. The present study seeks to appreciate the barriers towards OGD VCC by adopting a qualitative research methodology wherein interviews are being conducted with key personnel manning the OGD initiatives in Brazil. Impediments veering around VCC may be counted the internal, social and cultural and data factors. Findings from the present study lend credence to the fact that a systematic strategizing is important for the success of OGD VCC lest Value Co‐Destruction (VCD) happen. From a developing country's perspective, the present study acts as a sounding‐board for bearing in mind the caveats deduced vis‐a‐via the success of the VCC processes.
Parent personality traits and problem behavior in adolescence: The mediating role of adolescent personality
Authors: Robson Davina A. , Allen Mark S. , Laborde Sylvain 
Published: March 2023

AbstractIntroductionParental personality traits are predicted to influence offspring outcomes through parenting behavior and offspring personality traits. This study explored whether mother and father personality traits relate to offspring behavior problems in mid‐late adolescenceMethodIn total, 3089 Australian adolescents (1576 boys, 1513 girls; Mage = 16.46 ± 0.50 years) and their parents completed questionnaires assessing personality, conduct problems, emotional and social functioning, antisocial and criminal behavior, cigarette smoking and drug use, at a single time‐point.ResultsAfter controlling for sociodemographic factors, results showed that problem behaviors in adolescence were most consistently related to mothers' scores on neuroticism and conscientiousness, and fathers' scores on neuroticism. Father personality traits were most important for antisocial and criminal behavior, whereas mother personality traits were most important for social and emotional functioning. Moderation analysis showed that associations between fathers' personality traits and some adolescent outcomes (cigarette smoking and drug use) were stronger for adolescent boys than for adolescent girls. Mediation models further demonstrated that adolescent personality traits mediated associations between parent personality and adolescent outcomes in almost all cases. Indirect effects expressed as a percentage showed that between 1.4% and 33.3% of the variance in the association between parent personality and adolescent outcomes was shared with the corresponding adolescent personality trait.ConclusionsOverall, the findings of this study provide evidence that traits inherited (directly or indirectly) from parents might have an important role in shaping problem behavior in adolescence.
The dependences of mesenchymal stem cells commitments on the size, concentration, internalization and exposure time of Iron Oxide Nanoparticles through F‐actin, Lamin A and ROS
Authors: Bai Yuying , Tian Dawei , Ren Zhengxin , Yue Dangyang , Ren Qian , Pei Li , Pan Jun 
Published: March 2023

AbstractThough magnetic iron oxide nanoparticles (IONPs) are approved for clinical use as contrast agents for MR imaging in United States and Europe, and are widely used to label cells in research, the relationship between IONPs and mesenchymal stem cells (MSCs) is not fully addressed. Here the effects of consistently appeared γ‐Fe2O3 on the lineage commitment of MSCs were studied to optimize applications of IONPs in MSCs upon verification of viability. 30 nm 10 μg/mL induced highest promotions on osteogenesis, while 30 and 50 nm of 100 μg/mL elicited most chondrogensis in 14 days, where the effects on ALP, GAG and SOX9 appeared after 7 days, while on RUNX2 came out after 10 days. γ‐Fe2O3 enhanced intracellular and extracellular Fe3+ and ROS, modulated F‐actin and decreased Lamin A of MSCs at different time scale. The disturbances of F‐actin, Lamin A or ROS altered the effects of γ‐Fe2O3 on MSC differentiation. Our results demonstrate that different size, concentration and modulation of γ‐Fe2O3 are needed in its MSC applications for bone and cartilage tissues. Furthermore, an undocumented phenomenon that the modulation of F‐actin affected the Lamin A expression in MSCs was observed.