bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demographic recruitment bias of adults in United States randomized clinical trials by disease categories between 2008 to 2019: a systematic review and meta-analysis
Authors: Buffenstein Ilana , Kaneakua Bree , Taylor Emily , Matsunaga Masako , Choi So Yung , Carrazana Enrique , Viereck Jason , Liow Kore Kai , Ghaffari-Rafi Arash 
Published: January 2023

AbstractTo promote health equity within the United States (US), randomized clinical trials should strive for unbiased representation. Thus, there is impetus to identify demographic disparities overall and by disease category in US clinical trial recruitment, by trial phase, level of masking, and multi-center status, relative to national demographics. A systematic review and meta-analysis were conducted using MEDLINE, Embase, CENTRAL, and ClinicalTrials.gov, between 01/01/2008 to 12/30/2019. Clinical trials (N = 5,388) were identified based on the following inclusion criteria: study type, location, phase, and participant age. Each clinical trial was independently screened by two researchers. Data was pooled using a random-effects model. Median proportions for gender, race, and ethnicity of each trial were compared to the 2010 US Census proportions, matched by age. A second analysis was performed comparing gender, race, and ethnicity proportions by trial phase, multi-institutional status, quality, masking, and study start year. 2977 trials met inclusion criteria (participants, n = 607,181) for data extraction. 36% of trials reported ethnicity and 53% reported race. Three trials (0.10%) included transgender participants (n = 5). Compared with 2010 US Census data, females (48.3%, 95% CI 47.2–49.3, p < 0.0001), Hispanics (11.6%, 95% CI 10.8–12.4, p < 0.0001), American Indians and Alaskan Natives (AIAN, 0.19%, 95% CI 0.15–0.23, p < 0.0001), Asians (1.27%, 95% CI 1.13–1.42, p < 0.0001), Whites (77.6%, 95% CI 76.4–78.8, p < 0.0001), and multiracial participants (0.25%, 95% CI 0.21–0.31, p < 0.0001) were under-represented, while Native Hawaiians and Pacific Islanders (0.76%, 95% CI 0.71–0.82, p < 0.0001) and Blacks (17.0%, 95% CI 15.9–18.1, p < 0.0001) were over-represented. Inequitable representation was mirrored in analysis by phase, institutional status, quality assessment, and level of masking. Between 2008 to 2019 representation improved for only females and Hispanics. Analysis stratified by 44 disease categories (i.e., psychiatric, obstetric, neurological, etc.) exhibited significant yet varied disparities, with Asians, AIAN, and multiracial individuals the most under-represented. These results demonstrate disparities in US randomized clinical trial recruitment between 2008 to 2019, with the reporting of demographic data and representation of most minorities not having improved over time.
Effect of dialysis modalities on risk of hospitalization for gastrointestinal bleeding
Authors: Huang Chieh-Hsin , Chao Jo-Yen , Ling Tsai-Chieh , Wu Jia-Ling , Sung Junne-Ming , Sun Chien-Yao , Cheng Ya-Yun , Chang Yu-Tzu 
Published: January 2023

AbstractDialysis patients are at risk of both thromboembolic and bleeding events, while thromboembolism prevention and treatment may confer a risk of major bleeding. Gastrointestinal (GI) bleeding is a great concern which can result in high subsequent mortality rates. Our object was to clarify whether hemodialysis (HD) and peritoneal dialysis (PD) confer different incidence of GI bleeding, and further assist individualized decision-making on dialysis modalities. We conducted a population-based retrospective cohort study which included all incident dialysis patients above 18 years old derived from the National Health Insurance database from 1998 to 2013 in Taiwan. 6296 matched pairs of HD and PD patients were identified. A propensity score matching method was used to minimize the selection bias. The adjusted hazard ratio for GI bleeding was 1.13 times higher in the HD group than in the PD group, and data from the unmatched cohort and the stratified analysis led to similar results. Among subgroup analysis, we found that the use of anticoagulants will induce a much higher incidence of GI bleeding in HD patients as compared to in PD patients. We concluded that PD is associated with a lower GI bleeding risk than HD, and is especially preferred when anticoagulation is needed.
Evaluation insight into Abu Zenima clay deposits as a prospective raw material source for ceramics industry: Remote Sensing and Characterization
Authors: Maged Ali , Abu El-Magd Sherif Ahmed , Radwan Ahmed E. , Kharbish Sherif , Zamzam Sara 
Published: January 2023

AbstractThe rapid development and mutations have heightened ceramic industrialization to supply the countries' requirements worldwide. Therefore, the continuous exploration for new reserves of possible ceramic-raw materials is needed to overwhelm the increased demand for ceramic industries. In this study, the suitability assessment of potential applications for Upper Cretaceous (Santonian) clay deposits at Abu Zenima area, as raw materials in ceramic industries, was extensively performed. Remote sensing data were employed to map the Kaolinite-bearing formation as well as determine the additional occurrences of clay reserves in the studied area. In this context, ten representative clayey materials from the Matulla Formation were sampled and examined for their mineralogical, geochemical, morphological, physical, thermal, and plasticity characteristics. The mineralogical and chemical compositions of starting clay materials were examined. The physicochemical surface properties of the studied clay were studied utilizing SEM–EDX and TEM. The particle-size analysis confirmed the adequate characteristics of samples for white ceramic stoneware and ceramic tiles manufacturing. The technological and suitability properties of investigated clay deposits proved the industrial appropriateness of Abu Zenima clay as a potential ceramic raw material for various ceramic products. The existence of high kaolin reserves in the studied area with reasonable quality and quantity has regional significance. It would significantly help reduce the manufacturing cost and overwhelm the high consumption rate. The ceramic manufacturers in the investigated areas are expected to bring steady producers into the industry in the long term to gain the advantage of low-cost raw materials, labor, and factory construction.
Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy
Authors: Sharpe Ashley N. , Oldach Maureen S. , Rivas Victor N. , Kaplan Joanna L. , Walker Ashley L. , Kovacs Samantha L. , Hwee Darren T. , Cremin Peadar , Morgan Bradley P. , Malik Fady I. , Harris Samantha P. , Stern Joshua A. 
Published: January 2023

AbstractHypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiac disease in humans and cats and lacks efficacious pharmacologic interventions in the preclinical phase of disease. LV outflow tract obstruction (LVOTO) is commonly observed in HCM-affected patients and is a primary driver of heart failure symptoms and reduced quality of life. Novel small-molecule cardiac myosin inhibitors target actin-myosin interactions to alleviate overactive protein interactions. A prospective, randomized, controlled cross-over study was performed to evaluate pharmacodynamic effects of two doses (0.3 and 1 mg/kg) of a next-in-class cardiac myosin inhibitor,aficamten(CK-3773274, CK-274), on cardiac function in cats with the A31PMYBPC3mutation and oHCM. Dose-dependent reductions in LV systolic function, LVOT pressure gradient, and isovolumetric relaxation times compared to baseline were observed. Promising beneficial effects of reduced systolic function warrant further studies of this next-in-class therapeutic to evaluate the benefit of long-term administration in this patient population.
A computational study on the structure–function relationships of plant caleosins
Authors: Saadat Fatemeh 
Published: January 2023

AbstractPlant cells store energy in oil bodies constructed by structural proteins such as oleosins and caleosins. Although oil bodies usually accumulate in the seed and pollen of plants, caleosins are present in various organs and organelles. This issue, coupled with the diverse activities of caleosins, complicates the description of these oleo-proteins. Therefore, the current article proposes a new classification based on the bioinformatics analysis of the transmembrane topology of caleosins. Accordingly, the non-membrane class are the most abundant and diverse caleosins, especially in lower plants. Comparing the results with other reports suggests a stress response capacity for these caleosins. However, other classes play a more specific role in germination and pollination. A phylogenetic study also revealed two main clades that were significantly different in terms of caleosin type, expression profile, molecular weight, and isoelectric point (P < 0.01). In addition to the biochemical significance of the findings, predicting the structure of caleosins is necessary for constructing oil bodies used in the food and pharmaceutical industries.
Anisotropic distortion in the perceived direction of motion on the arm
Authors: Kuroki Scinob 
Published: January 2023

AbstractSkin covers the entire body, and its thickness and distribution of mechanoreceptors vary markedly across body parts. It has been shown that the brain is not able to fully compensate for such anisotropy, and as a result, the representational space of touch differs depending on which parts the stimulus is applied to. Here, by contrasting the hand and arm, we investigated the difference in perceived motion. Using a large-area braille display, we were able to present precisely controlled touchable motion stimuli with randomizing stimulus trajectories and varying the size. We found a new perceptual illusion in which the motion direction of stimuli perceived on the arm is rotated regionally, or even flipped. In particular, obliquely moving stimuli that move toward the distal radial are perceived as move toward the proximal radial, and stimuli that move toward the proximal ulnar are perceived as move toward the distal ulnar. This illusion was not observed on the palm, regardless of compensation for the stimulus size. Current study adds a clear example of how presenting the same motion stimuli to different body parts results in a different perception, emphasizing that the perceived tactile space is not uniform and needs to be examined in detail.
Self-cleaning superhydrophobic fly ash geopolymer
Authors: Chindaprasirt Prinya , Jitsangiam Peerapong , Pachana Pumipat K. , Rattanasak Ubolluk 
Published: January 2023

AbstractBuilding materials with hydrophobic surfaces can exhibit increased service life by preventing moisture absorption or diffusion through their surfaces. For concrete used in construction, this hydrophobicity can prevent the corrosion of reinforcing steel bars. Geopolymers are a new cement-free binding material that have been extensively studied to replace Portland cement. However, similar to normal concrete, geopolymers are susceptible to the intake of moisture. This paper presents the fabrication of a superhydrophobic and self-cleaning surface on a fly ash geopolymer as a method to prevent moisture intake. A composite coating of polydimethylsiloxane (PDMS) solution containing dispersed polytetrafluoroethylene (PTFE) or calcium stearate (CS) microparticles was applied by dip-coating to form the hydrophobic surface. Additionally, fly ash was incorporated with the PTFE and CS microparticles to increase surface roughness and reduce material cost. The experimental results showed that the coating containing CS microparticles yielded a hydrophobic surface with a contact angle of 140°, while those containing PTFE microparticles provided a superhydrophobic surface with a contact angle of 159°. The incorporation of fly ash resulted in increased surface roughness, leading to a larger contact angle and a smaller sliding angle. A contact angle of 153° with a sliding angle of 8.7° was observed on the PTFE/fly ash-coated surface. The cleaning process was demonstrated with a test whereby dust was removed by water droplets rolling off the surface. The tested coating exhibited self-cleaning and waterproofing properties and could thus improve the sustainability of materials in building construction.
Plasmonic vortices for tunable manipulation of target particles, using arrays of elliptical holes in a gold layer
Authors: Ghanei Amir Mohammad , Aghili Abolfazl , Darbari Sara , Talebi Nahid 
Published: January 2023

AbstractHere, we numerically prove that light with linear polarization can be coupled to surface plasmon polaritons at an elliptical hole perforated in a gold layer to generate plasmonic vortex (PV). Benefiting from the smooth variation of the minor to major ellipse axes, a gradual variation in the phase profile of the generated PV is achieved. Regarding this, three types of independent arrays of elliptical holes are presented, which can produce uniform and high quality PVs with different topological charges at the center of the arrays. The first array can produce PV with topological charges of + 1 and − 1, depending on the polarization orientation of the incident light. In the second one, the topological charge of the PV can be switched between 0 and + 2, by switching the polarization direction of the incident light. In the third array, a robust PV with topological charge of + 1 is generated independent of possible tolerances in the polarization orientation. In order to use the generated PVs for plasmonic tweezing application, there are side fringes around the central vortex of the arrays that should be eliminated. To produce a single vortex, we propose metal-insulator-metal (MIM) structures, screening excessive fringes and allowing the central PVs to leak out. It is also demonstrated by simulation that target particles, such as gold and polystyrene spheres of subwavelength dimensions, can be efficiently manipulated by our MIM designs, suitable for different applications including local mixing, and applying switchable torque or force to target particles to explore their complete elastic characteristics.
Evolution of orbital angular momentum spectrum of broadband Laguerre–Gaussian beam in OPCPA process
Authors: Wang Aotian , Yu Lianghong , Li Jinfeng , Liang Xiaoyan 
Published: January 2023

AbstractIn this study, we numerically simulate the evolution of the orbital angular momentum (OAM) spectrum of a vortex laser beam in the optical parametric chirped pulse amplification (OPCPA) process, which is an effective technical method to realize ultra-intense and ultra-short vortex laser amplification. The results show that the proportion of the vortex laser beam with 100% topological charge (TC) of 1 decreases to 97.44% with the enhancement of the saturation amplification after amplification by a 15 mm length LBO pumped by a 526.5 nm laser with a pump intensity of 1.74 GW/cm2. Conversely, the beams with other topological charges generate and increase with the amplification. The simulation results are consistent with our previous experimental results. Meanwhile, compared with non-collinear OPCPA, collinear OPCPA can maintain well the proportion of TC $$l = 1$$

l
=
1

.
A follow-up study of early intensive behavioral intervention program for children with Autism in Syria
Authors: Mounzer Wissam , Stenhoff Donald M. , Alkhateeb Jamal M. , Al Khatib Amal J. 
Published: January 2023

AbstractWe examined the sustained effects of early intensive behavioral intervention (EIBI) on 66 children with autism spectrum disorder who participated in the Future Center’s EIBI program. Children were assessed using the childhood autism rating scale (CARS), autism behavior checklist (ABC), and adaptive behavior scale (ABS-Arabic) 3 years after leaving the program. Continued positive effects were observed in several areas, including adaptive behavior and autism symptoms. However, participants’ social skills might have declined on the ABS-Arabic after service withdrawal. Additionally, a significant negative association (p < .001) was found between participants’ performance on the CARS and the number of weekly trials. This is encouraging, given the lack of EIBI services and regional instability. Future research should increase the sample size and use a more rigorous design.
A model for estimating the brainstem volume in normal healthy individuals and its application to diffuse axonal injury patients
Authors: Fujimoto Gaku , Ubukata Shiho , Sugihara Genichi , Oishi Naoya , Aso Toshihiko , Murai Toshiya , Ueda Keita 
Published: January 2023

AbstractDiffuse axonal injury (DAI) is a subtype of traumatic brain injury that causes acute-phase consciousness disorders and widespread chronic-phase brain atrophy. Considering the importance of brainstem damage in DAI, a valid method for evaluating brainstem volume is required. We obtained volume measurements from 182 healthy adults by analyzing T1-weighted magnetic resonance images, and created an age-/sex-/intracranial volume-based quantitative model to estimate the normal healthy volume of the brainstem and cerebrum. We then applied this model to the volume measurements of 22 DAI patients, most of whom were in the long-term chronic phase and had no gross focal injury, to estimate the percentage difference in volume from the expected normal healthy volume in different brain regions, and investigated its association with the duration of posttraumatic amnesia (which is an early marker of injury severity). The average loss of the whole brainstem was 13.9%. Moreover, the percentage loss of the whole brainstem, and particularly of the pons and midbrain, was significantly negatively correlated with the duration of posttraumatic amnesia. Our findings suggest that injury severity, as denoted by the duration of posttraumatic amnesia, is among the factors affecting the chronic-phase brainstem volume in patients with DAI.
Effects of manufacturing errors of gear macro-geometry on gear performance
Authors: Chung Woo-Jin , Park Young-Jun , Choi Chanho , Kim Su-Chul 
Published: January 2023

AbstractIn gear design, gear performance metrics such as safety factors for tooth root stress and surface durability, peak-to-peak static transmission error (PPSTE), efficiency, mass, and volume are considered. They are calculated by the geometric parameters of gear macro- and micro-geometry, and manufacturing errors related to gear geometry significantly affect gear performance. However, previous studies have only focused on the micro-geometry errors. In this study, Monte Carlo-type robustness analysis was performed considering the manufacturing errors for tooth thickness, tip diameter, and center distance. Gear performance metrics except PPSTE were calculated based on the international standards and geometric characteristics. PPSTE was evaluated analytically due to lack of standards. When the errors were considered, two gear pairs with the safety factors satisfying the design requirements and similar performance for PPSTE, efficiency, mass, and volume showed different gear performances. There were many samples in gear pair 1 that could not satisfy the design requirements of safety factors, and gear pair 2 had the robustness of PPSTE not only at the specific torque but also with wide torque range when compared to gear pair 1. These results imply that considering the gear macro-geometry errors and robustness of PPSTE is significantly important when designing gears.
Application of infrared thermography for estimating residual stress in ground anchors for maintenance
Authors: Min Dae-Hong , Jang Byeong-su , Yoon Hyung-Koo 
Published: January 2023

AbstractCharacterizing the integrity of ground anchors is essential for examining their usability in the maintenance of soil structure. However, the lift-off test, which is generally used for this purpose, has limitations when applied to covering all installed ground anchors. The objective of this study is to assess the possibility of using infrared thermography to measure the residual stress in ground anchors as a noncontact technique that bypasses the disadvantages associated with existing techniques. A preliminary experiment is performed to determine the exact emissivity of the tested materials. Both passive and active methods, as representative techniques in infrared thermography, are applied. In the large-scale experiment, infrared images of four installed strands with growing stress in the range of 0–400 kPa at 100 kPa intervals are used in the passive method of measurement. For the active method, these same stress ranges are applied to a heated anchor head using a UTM machine. The results of the passive method show that the temperature increased and decreased according to load and unload steps. Values for the cooling rate index are deduced through the active method results, and reliable behavior are observed at 10 and 15 min. The number of pixels with huge temperature changes also changed with the loading step in both passive and active methods. This study demonstrates that infrared thermography is a suitable alternative method for assessing the residual stress in ground anchors as a type of noncontact technique.
New thioxothiazolidinyl-acetamides derivatives as potent urease inhibitors: design, synthesis, in vitro inhibition, and molecular dynamic simulation
Authors: Dastyafteh Navid , Noori Milad , Nazari Montazer Mohammad , Zomorodian Kamiar , Yazdanpanah Somayeh , Iraji Aida , Khalili Ghomi Minoo , Javanshir Shahrzad , Asadi Mehdi , Dianatpour Mehdi , Biglar Mahmood , Larijani Bagher , Amanlou Massoud , Mahdavi Mohammad 
Published: January 2023

AbstractTo identify potent urease inhibitors, in the current study, a series of thioxothiazolidinyl-acetamides were designed and synthesized. The prepared compounds were characterized by spectroscopic techniques, including FTIR, 1HNMR, 13CNMR, and elemental analysis. In the enzymatic assessments, it was demonstrated that all derivatives had significant urease inhibition with IC50 values in the range of 1.473–9.274 µM in comparison with the positive control hydroxyurea (IC50 = 100.21 ± 2.5 µM) and thiourea (IC50 = 23.62 ± 0.84 µM). Compound 6i (N-benzyl-3-butyl-4-oxo-2-thioxothiazolidine-5-carboxamide) was the most active agent with an IC50 value of 1.473 µM. Additionally, kinetic investigation and in silico assessments of 6i was carried out to understand the type of inhibition and behavior of the most potent derivative within the binding site of the enzyme. Noteworthy, the anti-urease assay against P. vulgaris revealed 6e and 6i as the most active agents with IC50 values of 15.27 ± 2.40 and 17.78 ± 3.75 µg/mL, respectively. Antimicrobial evaluations of all compounds reveal that compounds 6n and 6o were the most potent antimicrobial agents against the standard and resistant S. aureus. 6n and 6o also showed 37 and 27% inhibition in the development of biofilm by S. aureus at 512 µg/ml. Furthermore, the MTT test showed no toxicity up to 100 µM. Taken together, the study suggests that the synthesized thioxothiazolidinyl-acetamides bases derivatives may serve as potential hits as urease inhibitors.