bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Series of Peripherally Phthalocyanines (Zn, Pd and Cu): Spectroscopic Studies
Authors: Rahali Asma , Abderrahim Raoudha , Almeida-Marrero Verónica , de la Escosura Andrés , Torres Tomás 
Published: December 2022

Abstract:A new series of metallophthalocyanines (MPc) containing metals such as : Zn (II), Cu (II) and, Pd (II) were designed, synthesized, and characterized, using MS, IR and UV-Vis spectroscopy. A Suzuki cross-coupling reaction was investigated by using the Pd(dppf)Cl2 as a catalyst and cesium carbonate as a base to improve the yield of the precursor 2.6-di(pyridin-3-yl)- phenyl benzyl ether. The changes of metals, substituents, and positions increases the Q-band value from the monosubstituted to the octa-substituted macrocycles, and from Pd, to Cu to Zn complexes. All MPc showed quite similar IR spectra.
Synthesis, Characterization, ‘ADMET-SAR’ Prediction, DPPH Assay,
and Anti-Mycobacterium Study of 4-[(substituted benzyl) amino]benzo
hydrazides and its Hydrazones as the Acyl-CoA Carboxylase, AccD5
Inhibitors
Authors: Desale Vijay J. , Mali Suraj N. , Thorat Bapu R. , Yamgar Ramesh S. , Dharanguttikar Swapnali V. , Dharanguttikar Vyankatesh R. , Chtita Samir , Oliveira Mozaniel , Cruz Jorddy Neves 
Published: December 2022

Background:
Hydrazide-hydrazone derivatives have shown diverse biological activities,
such as antitubercular (anti-TB), antibacterial, antifungal, anticancer, anti-inflammatory, antiviral,
and antiprotozoal actions.

Objectives:
Hydrazide–hydrazones contain azomethine (-NH-N=CH-) group connected with carbonyl
group and are believed to be responsible for various pharmaceutical applications. They aid
in the synthesis of different five-membered heterocyclic systems, such as oxadiazole, triazoles,
etc.

Methods:
In the present study, various hydrazines/hydrazones were synthesized starting from 4-
amino benzoic acid derivatives. Structures of all 9 newly synthesized compounds (6a-6d and 8a-
8e) were further characterized by using various spectroscopic methods, such as 1H-NMR (Nuclear
Magnetic Resonance), FT-IR (Fourier-transform infrared spectroscopy), Gas chromatographymass
spectrometry (GC-MS), etc. Furthermore, molecular docking analysis against the acyl-CoA
carboxylase, AccD5 (PDB ID: 2A7S), was also carried out using the Glide module, which depicted
good binding scores than standard drugs. The anti-tuberculosis activity of all the hydrazides
and hydrazones (6a-6d and 8a-8e) were evaluated against the Mycobacterium tuberculosis H37
RV strain using the Alamar-Blue susceptibility (MABA) test. The activity was expressed as the
minimum inhibitory concentration (MIC) in μg/mL values. The antioxidant activity was also carried
out using a DPPH assay.

Results:
Our findings demonstrated highly encouraging in-vitro results (MABA assay, MIC: 1.2
μg/mL) of hydrazones as depicted by good antimycobacterial activity. The antioxidant results
showed a moderate to a good percentage of DPPH inhibition. Our in-silico ADMET analysis further
suggested good pharmacokinetic and toxicity-free profiles of synthesized analogues (6a-6d
and 8a-8e).

Conclusion:
Our results signify hydrazones/hydrazines as potential hit candidates against the future
developments of potent and safer anti-TB agents.
Bone Scaffold Materials in Periodontal and Tooth-supporting Tissue
Regeneration: A Review
Authors: Jahangirnezhad Mahmood , Mahmoudinezhad Sadaf Sadat , Moradi Melika , Moradi Kooshan , Rohani Ali , Tayebi Lobat 
Published: December 2022

Background and Objectives:
Periodontium is an important tooth-supporting tissue composed
of both hard (alveolar bone and cementum) and soft (gingival and periodontal ligament) sections. Due to
the multi-tissue architecture of periodontium, reconstruction of each part can be influenced by others.
This review focuses on the bone section of the periodontium and presents the materials used in tissue
engineering scaffolds for its reconstruction.

Materials and Methods:
The following databases (2015 to 2021) were electronically searched: ProQuest,
EMBASE, SciFinder, MRS Online Proceedings Library, Medline, and Compendex. The search was limited
to English-language publications and in vivo studies.

Results:
Eighty-three articles were found in primary searching. After applying the inclusion criteria, seventeen
articles were incorporated into this study.

Conclusions:
In complex periodontal defects, various types of scaffolds, including multilayered ones, have
been used for the functional reconstruction of different parts of periodontium. While there are some multilayered
scaffolds designed to regenerate alveolar bone/periodontal ligament/cementum tissues of periodontium
in a hierarchically organized construct, no scaffold could so far consider all four tissues involved
in a complete periodontal defect. The progress and material considerations in the regeneration of the bony
part of periodontium are presented in this work to help investigators develop tissue engineering scaffolds
suitable for complete periodontal regeneration.
Asafetida (Ferula asafoetida) and its Potential Risks on Respiratory Disorders
Authors: Salavatifar Maryam , Mahboubi Mohaddese , Sotoudeh Nia Sepideh 
Published: December 2022

Abstract:Ferula asafoetida is an endemic species in Iran and is rich in oleo-gum resin with high economic value in the world. One important application of F. assafoetida is its traditional use for the management of respiratory ailments. The aim of this review was to collect papers dealing with F. asafoetida oleo-gum resin in respiratory tract’s diseases in modern medicine. For preparing the manuscript the scientific databases (Google scholar, PubMed, Springer, Science Direct, Magiran), books, thesis, etc. were searched using the keywords of “Ferula asafoetida”, “Ferula scorodesma”, “Scorodesma foetida”, “Northex asafoetida” plus “respiratory tract”, "respiratory disorder" “infection”, “cough”, “trachea”, “traditional medicine” up to Feb 2022 and the collected data were summarized, analyzed, and discussed. The results of the investigation confirmed the traditional belief on the efficacy of Ferula asafoetida in the treatment of respiratory viral infection (Coronavirus, influenza), cigarette smoking, asthma, cough and cancer, but most studies were limited to in vitro. There was only one registered randomized, blinded, placebo controlled clinical trial for 300 mg F. asafoetida aqueous extract capsules (three times a day for 14 days) on 40 patients with COVID-19 without any published results. Although, the studies implied the efficacy of F. asafoetida in the treatment of respiratory treatments, but design large clinical studies for evaluating its efficacy and safety is essential in future investigations.
Direct Load Control Scheme for Flexible Loads under Automated Demand
Response Program for Peak Demand Management, Loss Minimization,
Asset Management, and Sustainable Development
Authors: Chauhan Rajeev Kumar , Maurya Sanjay Kumar , Chauhan Durg Singh 
Published: December 2022

Background:
Nowadays implementation of Demand Response (DR) programs in the distribution
grid is a necessary planning criterion for distribution utility. Implemented DR programs
should be automated, intelligent, well-educated, and more competent than the conventional augmentation
techniques to resolve Distribution Network (DN) constraints. Peak demand causes DN to approach
its maximum capacities. Peak demand also exceeds the sustainable limit of the DN resulting
disruption in electric supply, failures of various assets like transformers, feeders, etc.

Objective:
In this paper, a Direct Load Control (DLC) scheme for Flexible Loads (FLs) is modeled
& implemented under Automated Demand Response (ADR) program and tested on real 54-bus DN.

Methods:
This ADR program is implemented through Demand Response Aggregator (DRA) and
ADR Technology Solution Enablers (ADRTSE) to curtail the peak demand on the DN ADR is a
recent technology that may put off new generation (conventional- and non-conventional both).

Results:
It also enables the distribution utility to curtail the peak demand & its period ensuring reliability
of supply without restructuring, augmentation of existing infrastructure, and development of
new infrastructure.

Conclusion:
The result validates the effectiveness of ADR program for peak demand curtailment, asset
management, distribution network losses minimization, and for sustainable development of environment.
Mental Health Disorders in Healthcare Workers Exposed to COVID-19, Mashhad, Iran: A Cross-sectional Study
Authors: Saeidinia Amin , Ghanabri Ghazale , Akbari Adele , khazaei Fateme , Khani Najme , Khakshour Ali , Talebi Mahdi 
Published: December 2022

Background:Healthcare workers (HCWs) who are directly involved in the management of patients with SARS-CoV-2 infection are at higher risk of psychological disorders.Objective:In this study, we evaluated the risk factors related to mental health disorders in HCWs active in the management of the COVID-19 pandemic in Mashhad, Iran.Methods:This was a cross-sectional investigation performed between April 2020 and May 2020 at five referral centers in Mashhad, Iran. Patient Health Questionnaire (PHQ-9), 7-item Generalized Anxiety Disorder scale (GAD-7), Insomnia Severity Index (ISI), Impact of Event Scale–Revised (IESR), and VAS (for fear from COVID-19) to assess depression, anxiety, insomnia, distress and fear related to COVID-19 were filled. Risk factors were evaluated by the regression model.Results:Mean ± SD age of participants was 33.84 ± 7.03 years. Most were females (64.2%). Of 360 participants, 252 had some degree of an anxiety disorder (70%), 63.8% had depression, 55.8% had insomnia, and 72.8% had distress. Work experiences (OR: 0.94, 95% CI = 0.901- 0.983, p = 0.007), exposure to COVID-19 patients (OR: 2.54, 95% CI = 1.37-4.69, p < 0.001), and job status (OR: 1.40, 95% CI = 1.19 -1.54, p < 0.001) were significant predictors of anxiety. Age (OR: 1.15, 95% CI = 1.05-1.27, p = 0.002), exposure to COVID-19 patients (OR: 1.95, 95% CI = 1.04-3.64, p = 0.037), work experience (OR: 0.86, 95% CI = 0.78-0.93, p < 0.001), having children (OR: 0.58, 95% CI = 0.39- 0.87, p = 0.008), and being infected with COVID-19 (OR: 9.95, 95% CI = 1.92-51.64, p < 0.001) were the significant independent factors for depression in participants.Conclusion:COVID-19 could significantly affect HCWs mental health status, specifically depression. By targeting these predictors, health policymakers can reduce the burden of psychological disorders in HCWs.
Evaluation of prevailing draft loads in the couplings of the electric trains
Authors: Belyaev V. I. , Gorskiy D. V. , Stupin D. A. , Konyshkov A. N. 
Published: December 2022

Introduction. Until now, the requirements for manual and automatic couplers for locomotive-hauled passenger carriages and electric trains have been completely identical, despite the significantly lower level of longitudinal forces during the movement of multi-unit rolling stock with distributed traction. The introduction of specialised designs of coupling devices for electric trains led to the development of strength requirements that enable the creation of new models with smaller dimensions and weight. Operating experience has shown that parts of couplings may be destroyed, leading to the uncoupling of trains. Fatigue damage may cause accidents. However, there were studies of the draft loads of electric trains couplers in operation, on the basis of which it was possible to develop regulatory requirements for specialised coupling devices.Materials and methods. The authors measured the forces acting in the couplings of electric trains of various categories and types during normal operation, as well as the frequencies of the occurrence of forces of various levels. The article includes histograms based on the results of processing the received data showing the distribution of longitudinal forces acting on the inter-car couplers and the parameter characterising the accumulation of fatigue damage per 100,000 km. Results. According to the results of processing of the experimental data, the calculation of the accumulation of fatigue damage to the couplers was carried out and the requirements for their expected service life were established. Test procedures have also been developed to evaluate strength and fatigue resistance under high-cycle and low-cycle loading conditions. The article provides ground for introducing a correction factor into the procedure for processing test results, which makes it possible to perform life tests on equipment with different values of the load cycle asymmetry factor.Discussion and conclusion. The authors have evaluated the draft loads in coupling devices during the operation of electric trains, on the basis of which technical requirements and test methods were developed and approved by JSC Russian Railways. Development and acceptance of all new models of coupling devices for electric trains will be carried out in accordance with these regulatory documents.
Remote Consultations for People With Parkinson Disease and Cognitive Impairment: Interview Study With Patients, Caregivers, and Health Care Professionals
Authors: Pigott Jennifer Sarah , Armstrong Megan , Chesterman Elizabeth , Read Joy , Nimmons Danielle , Walters Kate , Davies Nathan , Schrag Anette 
Published: December 2022

Background
The COVID-19 pandemic led to many consultations being conducted remotely. Cognitive impairment is recognized as a potential barrier to remote health care interactions and is common and heterogeneous in Parkinson disease. Studies have shown remote consultations in Parkinson disease to be feasible, but little is known about real-life experience, especially for those with cognitive impairment. We explored the experiences and perceptions of remote consultations for people with Parkinson disease and cognitive impairment.

Objective
This study aimed to explore the experiences of remote consultations for people with Parkinson disease and cognitive impairment from the perspective of service users and professionals and investigate considerations for future service delivery.

Methods
Semistructured interviews were conducted remotely with 11 people with Parkinson disease and cognitive impairment, 10 family caregivers, and 24 health care professionals (HCPs) between 2020 and 2021. Purposive sampling was used. Interviews were audio-recorded, transcribed, and analyzed using reflexive thematic analysis.

Results
Overall, four themes were identified: “the nature of remote interactions,” “challenges exacerbated by being remote,” “expectation versus reality,” and “optimizing for the future.” Remote consultations were considered as “transactional” and less personal, with difficulties in building rapport, and considered to play a different role from that of in-person consultations. The loss of nonverbal communication and ability of HCPs to sense led to remote consultations being perceived as riskier by all groups. Issues arising from communication and cognitive impairment, balancing the voices of the person with Parkinson disease and the caregiver, and discussions of the future affect this population specifically. Remote consultations were reported to have been more successful than anticipated in all 3 groups. Obstacles were not always as expected; for example, age was less of a barrier than predicted. Video consultations were perceived as being preferable to telephone consultations by many participants, but not accessible to all people with Parkinson disease. With widespread expectation of ongoing remote consultations, potential improvements for these 3 groups and health care services were identified, including practice, preparation, increased awareness of issues, expectation management by HCPs, and more time and flexibility for consultations.

Conclusions
Advantages and challenges of remote consultations for this population are identified. Consultations could be improved with increased support, practice, preparation, awareness of issues, and more time and flexibility within services.
Improving Knowledge About Pregnancy for Deaf South African Women of Reproductive Age Through a Text Messaging–Based Information Campaign: Mixed Methods Study
Authors: Haricharan Hanne Jensen , Hacking Damian , Lau Yan Kwan , Heap Marion 
Published: December 2022

Background
Signing Deaf South Africans have limited access to health information and, consequently, limited knowledge about health. Maternal and neonatal mortality rates are high. Cell phone use is high, making it a potentially effective way of communicating about maternal and child health.

Objective
The primary aim of this study was to assess whether an SMS text messaging–based health information campaign could improve knowledge about pregnancy, antenatal care, and healthy living during pregnancy for signing Deaf South African women of reproductive age. The secondary aim was to evaluate the acceptability of such an intervention.

Methods
This study was designed as a pretest-posttest study. A baseline questionnaire assessed participants’ knowledge about pregnancy, antenatal care, and healthy living during pregnancy before an SMS text messaging–based information campaign was conducted. After the campaign, an exit questionnaire was administered containing the same questions as the baseline questionnaire with additional questions on general acceptability and communication preferences. The results were compared between baseline and exit using the McNemar and Wilcoxon signed rank tests. A focus group aimed to obtain further information on the impact and acceptability of SMS text messages. The focus group was analyzed inductively.

Results
The study showed a statistically significant improvement in overall health knowledge among participants. Despite this, some participants found the medical terminology challenging to understand. Several ways of improving SMS text messaging campaigns for the Deaf were identified, including using Multimedia Messaging Services with a person signing messages and linking information campaigns to a communication service that would enable Deaf people to pose questions. The focus group also suggested that SMS text messages might play a role in motivating healthy behaviors during pregnancy.

Conclusions
The SMS text messaging campaign effectively improved Deaf women’s knowledge about pregnancy, antenatal care, and healthy living during pregnancy and has the potential to affect health behavior. This contrasts with a similar study on hearing pregnant women. This suggests that SMS text messages may be particularly effective in improving Deaf people’s health knowledge. However, attention should be paid to Deaf participants’ specific needs and communication preferences to optimize impact. The potential of using SMS text messaging campaigns to affect behavior should be studied.

Trial Registration
Pan-African Clinical Trials Registry (PACTR) PACTR201512001352180; https://tinyurl.com/3rxvsrbe
Effect of Al Concentration over ZnO-Al2O3 Physicochemical Characteristics and Removal of Remazol Red RB
Authors: Purwaningrum Widia , Sari Fingky Pristika , Julinar Julinar , Ahmadi Adiq , Said Muhammad 
Published: December 2022

ZnO is one of the widely used semiconductors due to its high photocatalytic activity. The inactivity of ZnO in the visible range could be enhanced by combining the ZnO with Al. In this study, the photocatalytic activity of ZnO-Al2O3 on Remazol Red RB was investigated. The effect of the ratio mass of ZnO-Al2O3 (1:0.05, 1:0.07, and 1:0.10) was also evaluated. The photocatalyst would be characterized using XRD, SEM-EDX, and UV-Vis DRS. The characterization showed that photocatalysts were successfully synthesized. The XRD analysis showed that the optimum ratio mass of ZnO-Al2O3 was achieved by 1:0.05, with the smallest crystal size of 13.3 nm. The SEM analysis showed that the surface of ZnO-Al2O3 (1:0.05) was easily granulated with smaller particle sizes than ZnO, and the shape tends to clump with the composites. The EDX analysis of ZnO-Al2O3 confirmed the presence of Zn, O, and Al elements. The photodegradation study showed that the optimum conditions were obtained at a contact time of 180 minutes at pH 6 with 91.04% dye removal. In addition, the effect of the initial concentration of the dye was achieved at 50 ppm with a dye removal of 89.26%. The study showed that the ZnO-Al2O3 exhibited adequate removal of Remazol red RB.
Effects of Nucleation and Crystal Growth Rates on Crystal Size Distribution for Seeded Batch Potash Alum Crystallization Process
Authors: Adnan Siti Zubaidah , Abdul Samad Noor Asma Fazli 
Published: December 2022

The driving force of the cooling crystallization process is supersaturation, where the supersaturation level during the crystallization process is crucial to grow the crystal sufficiently. Nucleation and crystal growth rates are two concurrent phenomena occurring during crystallization. Both are supersaturation functions that determine the growth of seed crystals and the formation of fine crystals. Trade-offs between nucleation and crystal growth are essential for achieving the large size of seed crystals with the minimum number of fine crystals. Thus, the objective of this study is to analyze the effects of nucleation and crystal growth rates on final product quality, which is crystal size distribution (CSD). Modeling of the crystallization process using a potash alum case study is highlighted and simulated using Matlab software. Then, the effects of nucleation rate, crystal growth rate, and both nucleation and crystal growth rates on CSD are evaluated using local sensitivity analysis based on the one-factor-at-a-time (OFAT) method. Based on simulation results for all strategies, a low combined rate delivers the best performance of the final CSD compared to others. Its primary peak has a mean crystal size of 455 µm with 0.0078 m3/m volume distribution. This means that the grown seed crystals are large with high volume distribution compared to the nominal strategy, which is at the mean crystal size of 415 µm and 0.00434 m3/m. Meanwhile, the secondary peak has the mean crystal size of 65 µm, 0.00028 m3/m in volume distribution. This corroborates the least number of fine crystals at the considerably small size compared to nominal’s (0.00151 m3/m, 35 µm). Overall, the low nucleation and crystal growth rates strategy provides useful insights into designing temperature profiles during the linear cooling crystallization process, whereby achievable supersaturation levels in obtaining large crystals with fewer crystal fines are provided via simulation.
A Canoa do Pantanal: uso, importância e conhecimento pelos indígenas, europeus e comunidades tradicionais
Authors: Peixoto José Luís dos Santos , Arruda Ariane Aparecida Carvalho de 
Published: December 2022

O objetivo deste estudo é compreender o uso, a importância e o conhecimento sobre a canoa monóxila do Pantanal pela comunidade local, pelos viajantes/imigrantes e pelos primeiros habitantes até os dias atuais. As fontes de informações são os dados fornecidos pelos manuscritos coloniais, entre os séculos XVII e XVIII; os estudos etnoarqueológicos sobre o processo de confecção da canoa pela comunidade pantaneira da Lagoa do Castelo, que mantém a tradição na fabricação e no seu uso; e os estudos etnohistóricos realizados sobre os grupos indígenas da região. Esses estudos revelaram que a canoa é um elemento preponderante nos conflitos étnicos, nas alianças, na mobilidade/dispersão espacial, nas relações de reciprocidade e na busca de recursos ambientais entre os distintos grupos étnicos. Palavras-chave: Canoa; Identidade Cultural; Grupos Étnicos; Pantanal.