bluuebunny/crossref_metadata_2025_split huggingface dataset:
The potential protective role of peripheral immunophenotypes in Alzheimer’s disease: A Mendelian randomization study
Authors: Zuo Chun-yan , Hu Zheng-wei , Fan Yu , Hao Xiao-yan , Li Meng-jie , Shi Jing-jing , Guo Meng-nan , Ma Dong-rui , Li Shuang-jie , Liang Yuan-yuan , Zhang Chan , Mao Cheng-yuan , Xu Yu-ming , Shi Changhe 
Published: February 2023

Abstract

Background
Previous studies have shown that peripheral immune dysregulation plays a paramount role in Alzheimer’s disease (AD), but whether there is a protective causal relationship between peripheral immunophenotypes and AD risk remains ambiguous.
Methods
Two-sample Mendelian randomization (MR) was performed using large genome-wide association study (GWAS) genetic data to assess causal effects between peripheral immunophenotypes and AD risk.
Results
This study identified four regulatory T cell (Treg) immunophenotypes—CD25 + + CD45RA- CD4 not regulatory T cell % T cell or CD4 + T cell; Secreting or Activated & secreting CD4 regulatory T cell % CD4 regulatory T cell; monocyte immunophenotype (HLA DR + + monocyte % monocyte); and dendritic cell (DC) subtype (HLA DR on myeloid Dendritic Cell)—that were protective against AD.
Discussion
These findings enhance the comprehension of the protective role of peripheral immunity in AD and provide further support for Treg and monocyte as potential targets for immunotherapy in AD.
Genetic polymorphisms of seven Trichoderma spp strains, their potential as biological control agent and growth promoter in tomato
Authors: Baca Samuel , Jiménez Oswalt R. , González Dorian , Huete-Pérez Jorge A. , Trabanino Rogelio , Avellaneda M. Carolina 
Published: February 2023

Abstract
Currently, many conventional methods for crop management have been insufficient to cope with the effects of climate change on food production such as droughts, heat, soil nutrients deficiency and the occurrence of new pathogen strains. The utilization of biological inputs, such as Trichoderma spp, has proved useful to improve crop production and food safety. However, in Central American countries there is not enough expertise to accelerate, in a practical way, its use in a broader scale. Here, we report for first time the study of a collection of Trichoderma spp strains from Nicaragua and Honduras with the purpose of analyzing their genetic diversity their potential as biological control agent and growth promoter in tomato. Genetic diversity was estimated by sequencing the nuclear ribosomal internal transcribed spacer (ITS) region. After, bifactorial experiments for testing the potential of two strains (TN1C and TC01) and two structures (conidia and microsclerotia) for controlling a harmful strain of Fusarium solani were conducted, followed by bifactorial experiments, considering the same factors, but analyzing their effects as growth promoter in greenhouse conditions. The DNA sequences amplified from ITS regions (1‒F and 4) indicate that there are two species, T. asperellum and T. harzianum, instead of one, consistent with morphological observations. Bayesian and parsimony modeling clustered Trichoderma strains by species providing novel insights about phylogenetic relationships and nucleotide polymorphisms. The strains TN1C and TC01 showed a reduction in the percentage of damage caused by F. solani. In addition, these strains increase the percentage of seed germination, plant height, stem diameter and number of leaves in tomato seedlings and plants. Root length and volume increased only in seedlings. Microsclerotia had a better performance with respect to conidia on plant growth development. These results strengthen ongoing research projects and incipient biological control programs oriented to benefit tomato farmers.
Elucidation of Furanone as Ergosterol pathway inhibitor in Cryptococcus neoformans
Authors: Sathiyamoorthy Jananishree , Rathore Sudarshan Singh , Mohan Suma , Maheshwari C. Uma , Ramakrishnan Jayapradha 
Published: February 2023

Abstract

In the era of antiretroviral therapy, the prevalence of Cryptococcal infection among HIV patients in developed countries has decreased considerably. However, C. neoformans ranks top among the critical priority pathogen that affects a wide range of immunocompromised individuals. The threat of C. neoformans is because of its incredibly multifaceted intracellular survival capabilities. Cell membrane sterols especially ergosterol and enzymes of its biosynthetic pathway are considered fascinating drug targets because of their structural stability. In this study, the ergosterol biosynthetic enzymes were modeled and docked with furanone derivatives. Among the tested ligands Compound 6 has shown a potential interaction with Lanosterol 14 α- demethylase. This best docked protein-ligand complex was taken further to molecular dynamics simulation. In addition, an in vitro study was conducted to quantify the ergosterol in Compound 6 treated cells. Altogether the computational and in vitro study demonstrates that Compound 6 has anticryptococcal activity by targeting the biosynthetic pathway of ergosterol.
A Lightweight Leader Election Algorithm for IoT: Cloud Storage Use Case
Authors: Kara Mostefa , Bounceur Ahcène , Hammoudeh Mohammad , Ngadi Hamza , Laouid Abdelkader 
Published: February 2023

Abstract
IoT devices in a distributed environment that work on shared data still have a necessity for a locking mechanism to safely take turns while updating shared data. However, we no longer have the notion of mutexes when working in a distributed system. That is where distributed locks and leader elections mechanisms come into the picture. In addition to its low power consumption, BROGO (Branch Optima to Global Optimum) Leader Election Algorithm offers a lot of powerful features so it is well suited for the IoT environment. This algorithm decreases energy consumption by 95\% compared with basic techniques. In this paper, we employ BROGO as a use case in the cloud storage domain.
Trends in the seasonal cycle of modelled streamflow across Australia, 1980–2018
Authors: Coleman Rachel Lauren , Jain Shaleen 
Published: February 2023

AbstractAustralian seasonal streamflow cycles represent diverse weather and climate variations and distinctive influences from coupled ocean-atmospheric phenomena, including monsoons, frontal systems, and El Nino-Southern Oscillation. Streamflow strongly modulates the health of ecosystems and is inextricably linked to communities through consumptive use and cultural and spiritual practices. To better understand the potential impacts of a changing climate, a comprehensive trend analysis of streamflow variability resolved at daily scales is pursued for 35 rivers across Australia using a serially complete modelled streamflow dataset (1979–2018) from the GloFAS-ERA5 operational global river discharge reanalysis. Analysis consisted of quantile regression to identify direction and significances of trends in low, median, and high flows, K-means clustering to identify grouping of data with similar features, and Poisson regressions to identify rainfall changes during low and high rainfall seasons. Results present comprehensive decreases at low, median, and high flows in southern continental river streamflow. Northern continental streamflows display increases and decreases throughout the year across flows, with increases more prevalent. Trends within upper and lower portions of the flow distributions reveal unique sub-seasonal time windows in the extremes, thus underscoring that trends across the full distribution of streamflow are necessary to understand vulnerability to human and environmental systems.
A CARTA A D’ALEMBERT: CRÍTICA AO ESPETÁCULO E AMOR PELA PÁTRIA POR JEAN-JACQUES ROUSSEAU
Authors: Façanha Luciano da Silva , Sousa Leonardo Silva 
Published: February 2023

Em sua Carta a D’alembert, o filósofo Jean-Jacques Rousseau consegue demonstrar para o leitor qual é o verdadeiro objetivo de um espetáculo teatral. O que também está em jogo são as impressões que ele pode causar em um público que não está habituado com a presença de espetáculos. Além de tentar demonstrar os efeitos negativos da instauração de uma casa de espetáculos em sua cidade, Rousseau está paralelamente demonstrando o amor e apreço a sua pátria, primando pela conservação da cultura de sua República. O presente artigo busca reforçar esse posicionamento do autor e sua incontestável crítica a sugestão de D’alembert: a instalação de um teatro de comédia em Genebra.
A BASE LÓGICA DA CIÊNCIA COGNITIVA E A CONTRIBUIÇÃO DO FUNCIONALISMO FILOSÓFICO DE JERRY FODOR
Authors: Gava Gustavo luiz 
Published: February 2023

Este artigo busca analisar os fundamentos iniciais da lógica no estudo do sistema nervoso do cérebro humano, que serviram de base para a Ciência Cognitiva, bem como o funcionalismo filosófico desenvolvido pelo filósofo norte americano Jerry Fodor e sua contribuição ao funcionamento da cognição tendo como princípio o escopo algorítmico. Para tanto, parte-se de três momentos: primeiro, a eclosão da ciência cognitiva e sua problemática científico-filosófica; segundo, o surgimento do funcionalismo filosófico na Ciência Cognitiva por meio do modelo computacional e; terceiro, o funcionalismo filosófico de Fodor e sua relação mente-mundo. O desenvolvimento axiomático das teorias funcionalistas do autor contribuiu para que a Ciência Cognitiva se utilizasse do modelo computacional para a compreensão do funcionamento cognitivo. Perspectiva fundamentada a partir do que compreende por processo cognitivo, linguagem do pensamento, partindo de analogias da I.A (inteligência artificial) entre mente = software e cérebro = hardware, analisadas desde seus primeiros estudos computacionais de preposições lógicas para compreender o funcionamento do sistema nervo.

Palavras-chave: ciência cognitiva; lógica; funcionalismo filosófico; linguagem do pensamento.
Aspectos político-pedagógicos em Gramsci
Authors: Stênico Joselaine Andréia de Godoy 
Published: February 2023

Este artigo tem como finalidade apresentar algumas reflexões promovidas por Antonio Gramsci. O texto apresenta sumariamente dados biográficos e aspectos da sua obra, além disso, traça os aspectos políticos pedagógicos e como alguns pesquisadores interpretam e/ou trabalham com a teoria gramsciana nas pesquisas científicas. Trata-se de um ensaio no contexto da abordagem qualitativa norteado pela análise bibliográfica. A concepção político pedagógica evidentemente não se esgota neste texto, mas colabora para traçar o perfil dos pensamentos do autor. Gramsci dedica-se a uma série de temas, alguns deles são: a formação dos intelectuais, a denúncia do caráter classista da escola, a escola única, o trabalho como princípio educativo, a relação do esponteneísmo na formação escolar, ao desenvolvimento da burguesia italiana e dos seus grupos intelectuais, ao papel da Igreja Católica na sociedade italiana, a literatura popular, do senso comum ao conceito de folclore, ao fordismo, entre outros temas. Alguns desses temas serão tratados neste texto. Assim, a importância de reavivar os pensamentos de Gramsci é porque por meio de seus escritos e suas atividades muito se contribuiu para o desenvolvimento cultural e para a educação. Além disso, Gramsci realizou uma análise crítica da história, sobretudo, no tocante a formação dos intelectuais e o ideário pedagógico, pois escreveu na prisão o texto mais importante já produzido sobre a função educativa e política dos intelectuais. O que chama a atenção na trajetória de Gramsci é a capacidade de resistir a todas as dificuldades que enfrentou na prisão no contexto do regime fascista e, mesmo assim, continuar escrevendo e produzindo dentro das condições que lhe foram permitidas.
PALAVRAS-CHAVE: Antonio Gramsci; História; Intelectuais; Caderno do Cárcere.
PLATÃO E A EDUCAÇÃO: POSSÍVEL INTER-RELAÇÃO ENTRE A ALEGORIA DA CAVERNA E A ANIMAÇÃO OS CROODS
Authors: Couto Débora Santos 
Published: February 2023

Este artigo, de cunho qualitativo e bibliográfico, propõe um diálogo entre a Alegoria da Caverna (Platão, 1997) e a animação Os Croods (2013). Pretende ver possíveis aproximações, bem como identificar a concepção de educação presente na narrativa platônica e na animação Os Croods. Recorre à Sociologia da Infância, em especial as contribuições de Sarmento (2007; 2008), na medida em que se compreende que a animação produzida se configura como produção cultural direcionada ao público infantil, que, historicamente, dado o contexto social de sua inserção, nem sempre teve as particularidades dessa etapa consideradas. Inferimos que a concepção de educação está permeada pelo contexto histórico no qual uma determinada sociedade está inserida, com a saída da caverna sendo considerado como fator de alcance de uma educação idealizada.
Palavras-chave: Educação. Platão. Alegoria da Caverna. Os Croods.
Deployment of a fault-tolerant videoconferencing server for a virtualization-based judicial system
Authors: Bokova O. I. , Khokhlov N. S. , Bokova A. O. 
Published: February 2023

Objective. The article discusses the issue of creating an infrastructure solution that allows, on the basis of modern information technologies, to organize a fault-tolerant videoconferencing server in the judicial system. The choice of technologies was determined by the need to use a video conferencing server in multi-user mode, as well as the convenience and ease of administration. The use of virtualization for the videoconferencing server will allow flexible functioning of both the system as a whole and all its components, isolate the use of resources, and configure monitoring to monitor the behavior of the system. The advantage of the solution presented in the article is its cost, which will be expressed only in the presence of a server grouping or its lease (instead of a monthly or annual fee to commercial organizations). Also, the advantages include the presence of an engineer of an average level of preparedness in the staff structure of the organization.
Modeling of general erosion of heterogeneous non-cohesive soils in river beds
Authors: Magomedova M. R. , Kurbanov R. A. 
Published: February 2023

Objective. The aim of the study is to develop a model for the erosion of noncohesive soils that are heterogeneous in size in river beds.Method. The mathematical model was developed using the theory of probability and the theory of outbursts of random processes, taking into account the normal law of distribution of the horizontal and vertical components of the instantaneous flow velocities and the Rayleigh law for the distribution of their maxima.Result. Statistical analysis of various models of erosion of non-cohesive soils heterogeneous in size in river channels was performed.Conclusion. The basic principles of studying various models of erosion of heterogeneous noncohesive soils in river beds, as well as the structure of calculation algorithms and programs compiled on its basis, allow us to continuously improve the calculation method and make adjustments to the corresponding modules of algorithms and programs.
Small Area Forecasting of Opioid-Related Mortality: Bayesian Spatiotemporal Dynamic Modeling Approach
Authors: Bauer Cici , Zhang Kehe , Li Wenjun , Bernson Dana , Dammann Olaf , LaRochelle Marc R , Stopka Thomas J 
Published: February 2023

Background
Opioid-related overdose mortality has remained at crisis levels across the United States, increasing 5-fold and worsened during the COVID-19 pandemic. The ability to provide forecasts of opioid-related mortality at granular geographical and temporal scales may help guide preemptive public health responses. Current forecasting models focus on prediction on a large geographical scale, such as states or counties, lacking the spatial granularity that local public health officials desire to guide policy decisions and resource allocation.

Objective
The overarching objective of our study was to develop Bayesian spatiotemporal dynamic models to predict opioid-related mortality counts and rates at temporally and geographically granular scales (ie, ZIP Code Tabulation Areas [ZCTAs]) for Massachusetts.

Methods
We obtained decedent data from the Massachusetts Registry of Vital Records and Statistics for 2005 through 2019. We developed Bayesian spatiotemporal dynamic models to predict opioid-related mortality across Massachusetts’ 537 ZCTAs. We evaluated the prediction performance of our models using the one-year ahead approach. We investigated the potential improvement of prediction accuracy by incorporating ZCTA-level demographic and socioeconomic determinants. We identified ZCTAs with the highest predicted opioid-related mortality in terms of rates and counts and stratified them by rural and urban areas.

Results
Bayesian dynamic models with the full spatial and temporal dependency performed best. Inclusion of the ZCTA-level demographic and socioeconomic variables as predictors improved the prediction accuracy, but only in the model that did not account for the neighborhood-level spatial dependency of the ZCTAs. Predictions were better for urban areas than for rural areas, which were more sparsely populated. Using the best performing model and the Massachusetts opioid-related mortality data from 2005 through 2019, our models suggested a stabilizing pattern in opioid-related overdose mortality in 2020 and 2021 if there were no disruptive changes to the trends observed for 2005-2019.

Conclusions
Our Bayesian spatiotemporal models focused on opioid-related overdose mortality data facilitated prediction approaches that can inform preemptive public health decision-making and resource allocation. While sparse data from rural and less populated locales typically pose special challenges in small area predictions, our dynamic Bayesian models, which maximized information borrowing across geographic areas and time points, were used to provide more accurate predictions for small areas. Such approaches can be replicated in other jurisdictions and at varying temporal and geographical levels. We encourage the formation of a modeling consortium for fatal opioid-related overdose predictions, where different modeling techniques could be ensembled to inform public health policy.
The consumption of sweet drinks differentially increases the expression of oxytocin in hypothalamic nuclei/ El consumo de bebidas dulces incrementa diferencialmente la expresión de Oxitocina en núcleos hipotalámicos
Authors: López Alonso Verónica Elsa , Díaz Urbina Daniel , Hernández Correa Samantha , Monreal González Luisa Miroslava , Escartín Pérez Rodrigo Erick , Mancilla Díaz Juan Manuel 
Published: February 2023

El consumo intermitente de bebidas dulces y refrigerios (snacks) entre comidas contribuyen con el desarrollo de la obesidad. La frecuencia de consumo y el tamaño de los refrigerios (incluyendo bebidas) con una carga calórica alta, conducen al sobrepeso. Se reconoce la participación de la oxitocina en el control de la alimentación, pero su mecanismo de acción no se ha establecido totalmente. Por tanto, el objetivo de esta investigación fue evaluar el efecto del acceso intermitente a una solución de sacarosa, sobre la expresión de las neuronas del núcleo paraventricular (PVN) y del núcleo supraótico (SON) que producen oxitocina (Oxt), y caracterizar la microestructura de la conducta de beber en ratas saciadas. Se tuvieron tres grupos de ratas macho Wistar saciadas por 23 h, y en la primera hora al inicio del periodo de luz, el grupo Control tuvo agua, el grupo Restringido 5g de una solución de sacarosa al 20% y el grupo Ad libitum acceso libre a la solución de sacarosa. Los sujetos incrementaron el consumo de la solución de sacarosa a pesar de estar saciados, esto debido a la interrupción del estado de saciedad y la demora del proceso de satisfacción. La actividad de las neuronas de Oxt se incrementó en ambos núcleos, en el grupo Restringido la mayor expresión se observó en el SON y en el grupo Ad libitum en el PVN. No se encontró correlación entre la cantidad de bebida ingerida y la actividad de las neuronas Oxt, se discuten los posibles mecanismos participantes.
Respon Masyarakat Aceh Terhadap Wakaf Asuransi Jiwa Syariah
Authors: Jalaluddin Jalaluddin 
Published: February 2023

Persepsi/respon terhadap Asuransi Jiwa Syariah belum baik di masyarakat, apalagi wakaf asuransi. Hal ini dapat dilihat pada perusahaan yang sudah menjual produk syariah lebih dari lima meliputi: PT.Asuransi Takaful Keluarga, PT. AIA, PT. Bumi Putera, PT. Prudensial Syariah hanya rata-rata 20 (dua puluh) polis perbulan yang artinya kurang dari satu polis perhari. Tujuan dari penelitian ini apakah dengan adanya produk wakaf polis asuransi akan ada perubahan persepsi masyarakat terhadap asuransi di tanah air, khususnya Aceh. Karena konsep wakaf dan asuransi sedikitnya ada kesamaan untuk kemaslahatan keluarga dan umum. Metode penelitian yang dilakukan adalah penelitian kualitatif deskriptif yaitu dengan cara wawancara secara mendalam kepada responden terpilih yang meliputi Badan Wakaf Indonesia (BWI) Provinsi Aceh, Majelis Permusyawaratan Ulama (MPU) Provinsi Aceh, akademisi, praktisi (perusahaan asuransi), nasabah asuransi, dan ulama dayah/pesantren. Penelitian tergolong penelitian lapangan (field research) dan kepustakaan (library research. Adapun hasil dari penelitian ini terbagi ke dalam dua persepsi/respon yaitu sangat positif dan normal/sedang demi kemaslahatan umat.
Fixation of an orthodontic anchor screw using beta-tricalcium phosphate in a screw-loosening model in rats
Authors: Nishioka-Sakamoto Kie , Hotokezaka Hitoshi , Hotokezaka Yuka , Nashiro Yukako , Funaki Mariko , Ohba Seigo , Yoshida Noriaki 
Published: February 2023

ABSTRACTObjectivesTo create an orthodontic anchor screw (OAS)–loosening model and to investigate whether filling the bone hole with beta-tricalcium phosphate (β-TCP) can fix the OAS against orthodontic force.Materials and MethodsBone holes with different diameters (1.6, 2.1, or 2.5 mm) were drilled in the tibias of 11-week-old male Wistar rats, and an OAS (3.0 mm in length and 1.2 mm in diameter) was inserted. After a healing period of 2 or 4 weeks, orthodontic force was applied, and the diameter of the bone hole appropriate for the loosening model was determined. Subsequently, under the loosening model, the bone hole was filled with β-TCP, orthodontic force was applied, and movement of the OAS and surrounding tissue changes were evaluated by micro–computed tomography images and histological specimen analysis.ResultsThe bone hole of 1.6 mm in diameter was employed as the OAS-loosening model. When β-TCP was inserted into the bone hole, the linear distance and mesial tipping angle of the OAS movement decreased markedly. Furthermore, the values of bone morphometry significantly increased with β-TCP filling.ConclusionsAn OAS-loosening model was established in rats and demonstrated that the loosening OAS was stabilized by β-TCP filling through bone formation. β-TCP may be useful for fixation of a loosening OAS.