bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: Myositis causing isolated neck extensor myopathy (INEM) exacerbated after vaccination
Authors: Holm-Yildiz Sonja , Pedersen Britt Staevnsbo , Kodal Louise Sloth , Dysgaard Tina 
Published: May 2023

Abstract
Background
Myositis is a group of inflammatory skeletal muscle diseases that in some cases may be linked to vaccines.3 Case reports of new-onset myositis and other autoimmune events have previously been reported after administration of the COVID-19 vaccine. 4–13 Furthermore, three large surveys have described patients with a self-reported flare of myositis following COVID-19 vaccination 14–16 To our knowledge, no cases of flares of myositis causing isolated neck extensor myopathy (INEM) have previously been reported.
Case presentation
A female known with stable myositis causing isolated neck extensor myopathy (INEM) with minor sequela developed severe weakness of the extensor muscle of the neck three weeks following the Pfizer-BioNTech COVID-19 Vaccine. Until vaccine administration, the patient exhibited a good response to immunosuppressants (prednisolone followed by rituximab). On clinical examination, she had a forward drop of the head and neck extensor muscle strength was 3/5 on the MRC scale. She was initially treated with prednisone and a course of rituximab with no clinical improvement. Subsequently, she was treated with intravenous immunoglobulins (IVIG). Within two weeks neck extensor weakness improved. She no longer had a head drop and neck extensor muscle strength was 4/5 on the MRC scale. The patient had a flare of myositis following immunization. The clinical course suggests that the vaccine may have triggered the flare, which could not be stabilized with previously effective treatment.
Conclusions
The time period between the COVID-19 vaccine and the exacerbation of myositis causing INEM suggests a link between the vaccine and the flare. The possible need for repeated vaccine boosters to maintain immunity against severe COVID-19 disease highlights the importance of acquiring more information on COVID-19 vaccine reactions in patients with pre-existing autoimmunity and on effective treatments vaccine related flares. Thus, clinicians should be aware of and report possible flares of autoimmune diseases following the vaccine. Nonetheless, the benefits of the COVID-19 vaccine outweigh the small risk of a myositis flare.
Biochemical Changes induced by Hydrogen Cyanamide (Dormex) Foliar Application in the Buds of ‘Askari’ Grape
Authors: Jamshidian Sadegh , Eshghi Saeid , Ramezanian Asghar , Jamali Babak 
Published: May 2023

Abstract

Short growing season is one of the main obstacles to the commercial production of grapes in regions experiencing cold/semi-cold climates. This is known to impact the quality and quantity of production. Consequently, this study was conducted to evaluate the effects of foliar application of hydrogen cyanamide (Dormex) solution (0, 1%) as a rest-break agent and its physiological and biochemical mechanisms, on 10-year-old Askari grape (Vitis vinifera 'Askari') trees, in a completely randomized block design in a factorial combination with three replications. The results showed that catalase activity was lower in the samples treated with hydrogen cyanamide solution (1%) compared to the untreated buds during the second, third, and fourth sampling dates, and hydrogen peroxide accumulated in the buds during the same period. Putrescine concentration was increased more than 6 folds in hydrogen cyanamide treated (1%) samples during the bud dormancy release period compared to the first sampling date, while spermidine and spermine concentration showed a significant decrease (about 90% and 80% respectively). Hydrogen cyanamide treatment also resulted in increased total nitrogen concentration in buds due to a rise in amino acids' concentration (proline, glutamine, arginine, ornithine, and citrulline). In conclusion, the current findings showed that the hydrogen cyanamide application enhanced bud break by 7.78% and 6.67%, 20 and 30 days after hydrogen cyanamide solution spray application, respectively.
ChatGPT in Education: Global Reactions to AI Innovations
Authors: Fütterer Tim , Fischer Christian , Alekseeva Anastasiia , Chen Xiaobin , Tate Tamara , Warschauer Mark , Gerjets Peter 
Published: May 2023

Abstract
The release and rapid diffusion of ChatGPT have caught the attention of educators worldwide. Some educators are enthusiastic about its potential to support learning, others are concerned about how it might circumvent learning opportunities or contribute to misinformation. To better understand reactions about ChatGPT concerning education, we analyzed Twitter data (16,830,997 tweets from 5,541,457 users). Based on topic modeling and sentiment analysis, we provide an overview of global perceptions and reactions to ChatGPT regarding education. ChatGPT triggered a massive response on Twitter, with education being the most tweeted content topic. Topics ranged from specific (e.g., cheating) to broad (e.g., opportunities), which were discussed with mixed sentiment. We traced that authority decisions can influence public opinions and that the average reaction on Twitter differs from scientific discussions. This study provides insights into people's reactions when new groundbreaking technology is released and implications for scientific and policy communication in rapidly changing circumstances.
Evaluation of Heat Wave Predictability Skills of Numerical Weather Models
Authors: Akinbobola Ademola , Raji Ibraheem 
Published: May 2023

Abstract

Significant changes is being experienced in the climate system due to the unprecedented rate of global warming. This has resulted in the increased frequency of weather extreme events which such as heatwave occurrence in the northern Nigeria. In order to mitigate the effects of heatwaves, early warning systems are needed to be implemented. Insufficient knowledge about the performance of the models is partly a factor that hinders the development of such systems. This study thus, addresses the gap by assessing the predictability skills of sub-seasonal to seasonal numerical weather model over different time lead and as well improves the predictability skills through the incorporation of deep learning to bias correct the model output at a 30-day lead period. The Excess heat index (EHI) was used to detect heatwave occurrence over the study area, using both observational and forecast data from selected S2S models at 5 -, 7 -, 15 -, and 30 – days lead time. Metrics employed to evaluate the skills of the models are; the Anomaly corelation coefficient (ACC), Symmetric External Dependency Index (SEDI) with each evaluating different strength of the models. The result of the analysis shows that the three models considered in this research overestimates the heat wave frequency in the region. This results in reduced reliability of the models in the region. Further analyses shows that the use of deep learning to bias the model output increases the forecast reliability in the region significantly.
On some Σ0B -generalizations of counting principles over V0
Authors: Ken Eitetsu 
Published: May 2023

Abstract

We formalize various counting principles and compare their strengths over $V^{0}$.In particular, we conjecture the following mutual independences between:
・a uniform version of modular counting principles and the pigeonhole principle for injections,
・a version of Oddtown theorem and modular counting principles of modulus p, where p is any natural number which is not a power of 2,
・and a version of Fisher's inequality and modular counting principles.
Then we give sufficient conditions to prove them. We give a variation of the notion of PHP-tree and k-evaluation to show that any Frege proof of the pigeonhole principle for injections admitting the uniform counting principle as an axiom scheme cannot have o(n)-evaluations. As for the remaining two, we utilize well-known notions of p-tree and k-evaluation and reduce the problems to existence of certain families of polynomials witnessing violations of the corresponding combinatorial principles with low-degree Nullstellensatz proofs from the violation of the modular counting principle in concern.
Isolation of Vagococcus fluvialis from the Bile of a Patient with Chronic Cholecystitis: A Case Report
Authors: zhang dan , Wang Xiaosu , Yu Jingdan , Dai Zheng , Li Qichao , Zhang Litao 
Published: May 2023

Abstract

BackgroundVagococcus fluvialis is a rare Gram-positive bacterium that is mainly found in animals or animal products, with only a few cases reported in humans. However, it has been implicated in human infections, particularly Vagococcus fluvialis. In this study, the researchers isolated Vagococcus fluvialis from bile samples of a patient with chronic cholecystitis. This is the first report of Vagococcus fluvialis isolation from bile in the literature. To provide valuable clinical information, the researchers performed comprehensive identification and drug susceptibility testing using various methods.Case PresentationThe article presents the case of a 66-year-old female who had previously undergone subtotal gastrectomy for diffuse large B-cell lymphoma and was admitted with complaints of abdominal pain. Laboratory tests showed the presence of chronic cholecystitis. Bile samples were cultured and identified as Vagococcus fluvialis using biochemical and mass spectrometry methods, with a 16S rRNA homology of 99.66% with Vagococcus fluvialis in GenBank. The bacteria were found to be sensitive to most antimicrobial drugs, except for clindamycin, erythromycin, and tetracycline. Drug sensitivity testing using the disk diffusion and micro-broth dilution methods provided valuable clinical information for treatment.ConclusionVagococcus fluvialis, a motile bacterium that can cause human infections, was isolated from the bile of a patient with chronic cholecystitis. Drug sensitivity testing showed most antimicrobial drugs are effective against it except for clindamycin, erythromyin, and tetracycline. This study provides valuable clinical information, but further research is needed on its pathogenicity, epidemiology, and clinical significance.
Soil moisture regulates the response of soil respiration to long-term warming in a southern boreal forest
Authors: Reich Peter B , Liang Guopeng , Stefanski Artur , Eddy William , Bermudez Raimundo , Montgomery Rebecca , Hobbie Sarah , Rich Roy 
Published: May 2023

Abstract

The effects of long-term climate warming on soil respiration and its drivers remain unclear in forests, which store approximately 40% of global soil carbon (C). This uncertainty may hinder realistic predictions of the global C cycling feedbacks under future climate warming. To address this knowledge gap, we conducted a long-term (13 years) climate change experiment, B4WarmED, at two southern boreal forest sites in northern Minnesota, USA. Treatments included simultaneous above- and belowground warming (ambient, + 1.7°C, and + 3.3°C) under different rainfall scenarios (100% and 60% of summer rainfall) and contrasting canopy conditions (open and closed). Across all treatments and years, soil respiration increased by 7% and 17% under + 1.7°C and + 3.3°C, respectively, compared to the ambient temperature plots. In all contexts (all warming levels, rainfall amounts, and canopy conditions), warming increased soil respiration more when soils were moist but less (or even decreased soil respiration) when soils were dry. Furthermore, these responses occurred regardless of whether soil moisture deficits were driven by low ambient rainfall, experimental rainfall reduction, canopy removal, or experimental warming. Our results suggest that factors affecting soil moisture should be accounted for when predicting or modeling the response of soil respiration to warming. Otherwise, warming effects on soil respiration, and thus the positive climate feedback, may be overestimated in forests that periodically experience low soil moisture, and especially those that will do so more frequently under future climate.
Needs and Expectations of Long-term Cancer Survivors
Authors: Zamudio Antonio , Romero-Arana Adolfo , Romero Adolfo , Camarero-Gómez Pilar , Rodríguez-Manjón Estefanía , Iglesias-Parra María Rosa 
Published: May 2023

Abstract

Cancer is an obvious social and world health issue. It is a social issue as its outreach affects not only mortality (it is the second cause of death in our environment) but also the costs due to morbility and distress it causes, as well as the losses and consequences in personal, family, work and even social areas. These issues require a multidisciplinary, complex approach. Luckily, more cancer patients get cured and there are more long-term cancer survivors every year. These survivors may require not well known health services, as the number of these patients has grown recently and their survival time is also longer. We are trying to find out the health needs of long-term cancer survivors and their perceptions and expectations of the care they received during their survival stage. To do so, we have designed a joint, cross-sectional descriptive study with a qualitative and quantitative approach. For the qualitative approach, we have used different focus groups representing different geographical areas of the Spanish territory. For the qualitative approach, we have used a validated questionnaire. The results obtained may offer a new perspective which could allow for a better planning of health services for these patients.
How does Soil Organic Matter affect Potato Productivity on Sandy Soil? Evidence from a Greenhouse Study
Authors: Rawal Ashmita , Lankau Richard A. , Ruark Matthew D. 
Published: May 2023

Abstract
Soil organic matter (SOM) can contribute to crop productivity through nutrient availability and soil improvement. However, SOM is typically low (< 2%) in the coarse-textured soils used for potato production. The potato cropping system is irrigated, frequently tilled, and fertilized causing potential nitrate leaching and contamination. The effect of varying levels of SOM on potato productivity in sandy soil is unclear. This study aimed to estimate the effect of varying SOM on potato productivity in sandy soils and to understand if nitrogen (N) mineralization was a primary mediator of this effect. Soil from nine fields in Wisconsin, USA (SOM range of 1.1 to 3.8%) were collected for a greenhouse study. Red Norland was the variety planted and vine, tuber, and total biomass and N uptake were measured. In-situ ion exchange resin strips and potentially mineralizable N (PMN) measured at harvest were used as proxies for N mineralization. We found that SOM had a positive effect on plant productivity. The effect was statistically significant for four productivity metrics (fresh matter whole biomass, dry matter vine biomass, and total N uptake in the vines and whole biomass) and marginally significant for four more. We found that N mineralization (as PMN) was a partial mediator of SOM effect on productivity doing a formal mediation test. Hence, it is likely that SOM improved plant productivity through mechanisms beyond just N acquisition by plants. Our results suggest future efforts should explore other mechanisms through which SOM can affect productivity.
Upfront neck dissection versus concurrent chemoradiotherapy in stage T1–3N3 hypopharyngeal carcinoma: A comparative study of clinical outcomes and predictive factors
Authors: Sakai Akihiro , Ebisumoto Koji , Iijima Hiroaki , Yamauchi Mayu , Teramura Takanobu , Yamazaki Aritomo , Watanabe Takane , Inagi Toshihide , Maki Daisuke , Fukuzawa Tsuyoshi , Okami Kenji 
Published: May 2023

Abstract
Purpose This study assessed the efficacy of upfront neck dissection (ND) versus concurrent chemoradiotherapy (CRT) in patients diagnosed with T1–3N3 hypopharyngeal carcinoma (HPC).Methods This retrospective study enrolled patients with T1–3N3 HPC who had undergone upfront ND followed by CRT (upfront group) or only CRT (CRT group). Local control rate, neck control rate, metastasis-free rate, disease-free survival, disease-specific survival, and overall survival were compared between the upfront and CRT groups. Univariate and multivariate analyses using Cox proportional hazards models were performed to identify the survival-related clinical and systemic factors.Results Forty-eight patients were enrolled in this study, with 18 in upfront group and 30 in CRT group. The groups differed significantly in terms of neck control rate (p = 0.000121) and disease-free survival (p = 0.0256). The upfront CRT group showed a significantly better overall survival (OS) than that of the unresectable CRT group (p = 0.046). Among the various factors, node status, body mass index, and platelet-to-lymphocyte ratio were significantly associated with OS in a univariate analysis.Conclusion Upfront ND can be recommended for T1–3N3 HPC, provided resectability is feasible.
Effect of HMB-FA Supplementation on Physiological Recovery Markers in Elite Wrestlers: A Double-Blind Placebo-Controlled Study
Authors: Tartibian Bakhtyar , Rezaei Bagher 
Published: May 2023

Abstract
β-Hydroxy-β-methylbutyrate free acid (HMB-FA) has been reported to improve skeletal muscle recovery after high-intensity exercise and attenuate blood markers of skeletal muscle damage. Therefore, this study was conducted to determine the effect of HMB-FA supplementation on physiological recovery markers in elite wrestlers. Twenty elite healthy wrestlers (aged 19–26 years) were randomly assigned to Exercise + HMB-FA (EXE + S, n = 10) and Exercise + Placebo (EXE + P, n = 10) groups for a simulated wrestling protocol. Compared to the EXE + P group, the EXE + S group showed significant decreases in physiological recovery markers such as creatinine (Cr), 3-methylhistidine (3-MH), urinary 3-methylhistidine/creatinine ratio (3-MH/CR), lactate dehydrogenase (LDH), and creatine kinase (CK), with noticeable reductions (p < 0.05). Additionally, there were significantly reduce in cortisol, and significant enhancements in insulin-like growth factor-1 (IGF-1) and IGF-1/cortisol ratio in the EXE + S group (p < 0.05). Finally, the perceived recovery status (PRS) as another physiological recovery marker in the EXE + P group was significantly reduced compared to the EXE + S group (p < 0.05), indicating a negative impact on recovery without HMB-FA supplementation. HMB-FA may attenuate muscle damage and improve recovery by modifying the cortisol, IGF-1, and IGF-1 / cortisol ratio and increase PRS in the simulated wrestling protocol.
Genetic Stability Analysis of the Temporary Immersion Bioreactor–Derived Sugarcane Seedlings with Simple Sequence Repeat (SSR) Markers
Authors: Saptari Rizka Tamania , Aksa Annisa Auliya , Setiawati Yuli , Riyadi Imron , Minarsih Hayati , Lindawati Sylvia , Prasetyo Muhammad Eko Riyo Bayu , Sinta Masna Maya , Sumaryono Sumaryono 
Published: May 2023

Abstract
Large-scale micropropagation of sugarcane using temporary immersion bioreactors (TIB) holds several advantages, such as produces high-yields, and lowers explants exposure to growth hormones in media which may affects the frequency of somaclonal variation (SV) in the micropropagated plants. In this study, simple sequence repeat (SSR) analysis was conducted to determine the relative genetic stability of TIB-derived sugarcanes using 15 SSR markers (producing over 200 DNA fragments ranging from 150 to 4,000 bp in size). The genetic stability was calculated as the Jaccard’s similarity index of the SSR patterns of TIB-derived sugarcanes compared to their conventionally-propagated counterparts. The genetic stability varied between 92% to 96% in three Indonesian sugarcane varieties (PSKA 942, PS 094, and PS 091) which is relatively high considering the high cell mass multiplication in TIB (up to 30 multiplies). Morphological observations also revealed no difference between TIB-derived sugarcanes and their mother plants, convincing the true-to-type of micropropagation products. This study demonstrated the high relative genetic stability of TIB-derived sugarcanes, opening the possibility for large-scale commercial application for plantations.
Open-ended comments in SIC-Ex, an assessment tool for residents leading Serious Illness Conversations
Authors: Ko Jenny J , des Ordons Amanda Roze , Ballard Mark S , Shenkier Tamara , Simon Jessica , Fyles Gillian , Lefresne Shilo , Hawley Philippa , Chen Charlie , McKenzie Michael , Sanders Justin J , Bernacki Rachelle 
Published: May 2023

Abstract
Purpose The Serious Illness Conversation (SIC) has emerged as a framework for conversations with patients with a serious illness diagnosis. This study reports on narratives generated from open-ended questions of a novel assessment tool, the SIC-Evaluation Exercise (SIC-Ex), to assess resident-led conversations with patients in oncology outpatient clinics.Methods We developed the SIC-Ex based on the Ariadne SIC framework. Seven resident trainees and ten preceptors were recruited from three cancer centres. Each trainee conducted a SIC with a patient, which was videotaped. The preceptors watched the videos and evaluated each trainee using the novel SIC-Ex and the reference Calgary-Cambridge Guide (CCG) at months 0 and 3. Two independent coders used template analysis to code the preceptors’ free-text narrative comments and identify themes/subthemes.Results Template analysis yielded 6 themes: behavioural attributes mapped to SIC, those mapped to CCG, those overlapping between SIC and CCG, trainees’ demeanors, rater mis-classification of comments, and comments on SIC-Ex. Narrative comments explored numerous verbal and non-verbal components essential to SIC. Some comments applied to both SIC and CCG (e.g. setting agenda, introduction, planning, exploring, non-verbal communication), whereas others mapped specific to one (e.g. SIC - identifying substitute decision maker, affirming commitment, introducing advance care planning, engaging family; CCG – using open ended questions, avoiding explanations, flow, time management).Conclusion Narrative comments generated by SIC-Ex provided a detailed and nuanced insight into trainee's competency in SIC, beyond numerical ratings and general communication skills assessed by CCG; they should continue to be a part of assessment.
Dimensionality and item characteristics of the 14-item Oral Health Impact Profile (OHIP) in Spanish patients undergoing prosthetic treatments
Authors: Salazar Jon , Rueda José Ramón , Ballesteros Javier 
Published: May 2023

Abstract
Background The 14-item Oral Health Impact Profile (OHIP) is the scale most frequently used to assess domains of oral health-related quality of life in patients undergoing oral treatments. The scale has shown validity, internal reliability, and temporal stability, but a formal analysis of item characteristics is still lacking.Methods We recruited adult participants undergoing prosthetic treatments from two dental clinical centers in Spain. We administered the scale once to a cross-sectional sample of patients (n = 398), and we did a retest with a follow-up subsample of patients (n = 153). We evaluated the underlying dimensional structure of the scale with Mokken analysis and its item characteristics with the Graded Response Model. We assessed the sensitivity to change in the follow-up sample with both the within-group raw mean change and the within-group standardized mean change.Results The Mokken analysis suggests a unidimensional structure of the scale with all items but one presenting adequate scalability. The overall scalability (H = 0.42) corresponds to a medium scale able to order participants along the latent trait of oral health-related quality of life. Most items present adequate scalability, discrimination, and information indexes. The exceptions are two items of the functional limitation domain that show outlying values from the rest. The sensitivity to change is adequate and shows an increasing trend with time since the intervention.Conclusions In this study, the 14-item Oral Health Impact Profile has shown appropriate psychometric characteristics at the item and overall scores level. It is unidimensional, allows to order patients on the construct of interest, and is sensitive to change.