bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studi Perbandingan Metode Prefrence Selection Index (PSI) Dengan Simple Additive Weighting (SAW) Dalam Pemilihan Laptop
Authors: Haqi Damanik Dea Insyirah , Triandi Budi 
Published: June 2023

Dalam kehidupan modern saat ini dan semakin cepat berkembangnya dunia teknologi informasi dan komunikasi. Hingga saat ini laptop telah menjadi kebutuhan yang penting bagi setiap orang yang membutuhkannya. Laptop telah menjadi kebutuhan dasar untuk menunjang kegiatan pendidikan maupun aktifitas bisnis. Dengan adanya laptop kegiatan sehari-hari menjadi lebih mudah, cepat, efisien dan resiko kesalahan dapat dikurangi. Permasalahan yang terjadi saat ini ialah bagaimana seorang customer menentukan spesifikasi laptop seperti apa yang sedang dicari, hal ini membuat pengguna menjadi kesulitan dalam menentukan pilihan yang sesuai dengan kebutuhannya. Untuk itu dengan adanya sebuah permasalahan tersebut maka dibutuhkan sebuah metode sitem pendukung keputusan yang dapat membantu customer dalam memilih laptop sesuai spesifikasi yang dibutuhkan. Dan metode yang dipilih untuk menyelesaikan permasalahan ini ialah dengan mengkombinasikan metode simple additive weighting dan preference selection index. Metode kombinasi ini digunakan karena akan membandingkan setiap alternatif dengan presentase metode yang berbeda, sehingga hal ini sangat cocok untuk pada penelitian pemilihan latop.
Las redes educativas virtuales en el entorno docente: participación y trabajo en sus espacios web
Authors: Hernández Elena , Navarro María José 
Published: June 2023

The development of networking among teachers is currently considered essential as it contributes to sharing and working on training aspects of the profession. This paper provides a study based on a documentary analysis of five virtual educational networks to learn about their operation and management, composition and work topics. For the collection of data, a Network Sheet for the analysis of documents and an Analysis Guide with information categories of each of the networks studied have been used. The results highlight that virtual networks are constituted to provide resources, support to teachers and share knowledge; the working modality is the “multi-network” group and the resources available to them usually come from the Governments and Autonomous Communities to which each one of them belongs. There is little data to assess the impact, although the Networking Projects launched have a positive assessment by teachers, they are mostly useful and are considered favorable for the educational community, contributing to generate the analysis of the needs of the schools and communities to which they belong, as well as providing real training for the professional development of teachers.
El desarrollo del trabajo en red del profesorado se considera en la actualidad fundamental ya que contribuye a compartir y trabajar aspectos formativos de la profesión. En este trabajo se aporta un estudio basado en un análisis documental de cinco redes educativas virtuales para conocer su funcionamiento, gestión, composición y temas de trabajo. Para la recogida de datos se han empleado una Ficha de Red para los documentos y una Guía de Análisis con categorías de información de cada red estudiada. Los resultados destacan que las redes virtuales se constituyen para aportar recursos y apoyos a los docentes y compartir conocimientos; la modalidad de trabajo es la agrupación “multired” y los recursos de los que disponen suelen provenir de Gobiernos y Comunidades Autónomas a las que pertenecen cada una de ellas. Son escasos los datos para valorar el impacto, aunque los Proyectos de trabajo en red puestos en marcha tienen una valoración positiva por parte del profesorado, son útiles en su mayoría y se consideran favorables para la comunidad educativa, contribuyendo a generar el análisis de las necesidades de los centros escolares y comunidades a las que pertenecen, así como aportan una formación real para el desarrollo profesional del profesorado.
Evaluation of Non Enzymatic Status in Antioxidant Capital in Senegalese Type 2 Diabetics
Authors: Thiam Souleymane , Toure M. , Samba A. , Ardja A. A. , Ndiaye A. , Coly N. , Soumah I. Y. , Diedhiou F. , Agossou H. H. H. , Tounkara A. R. , Dia F. K. S. T. , Ba R. , Faye I. , Gueye M. M. , Diouf N. N. , Cisse F. , Diatta A. , Diallo F. 
Published: June 2023

Oxidative stress appears very early in the history of type 2 diabetes complications. It is associated to glucose oxidation but also to lipid peroxidation. This stress can be accentuated by a decrease in the antioxidant capacities in diabetics, especially if there are other comorbidities. The objective of this study was to evaluate the antioxidant capacity of Senegalese type 2 diabetics and to identify the associated risk factors.
We conducted a prospective study in 40 persons with type 2 diabetes. Factors related to age, sex, BMI, and BP were determined. For biological parameters, we measured blood glucose at empty stomach, glycated haemoglobin, total cholesterol, HDL, triglycerides and LDL, urea and creatinine, uric acid, albumin, total bilirubin, copper, and zinc.
The mean age of the population was 58±11.24 years with a predominance of subjects aged over 60 (52.5%). The sex ratio was 1.11 with 52.5% male. Antioxidant capital was reduced in 60% of patients, with a predominance of women (35%). This reduction was marked by hypoalbuminemia (32.5%), hypozincemia (22.5) and an increase in the Cu/Zn ratio (30%). A strong correlation was found between the Cu/Zn ratio and total cholesterol (r=0.911; p<0.0001) as well as LDL (r=1; p=0.0001). Dyslipidaemia was found to be the most associated comorbidity with decreased oxidative capacity with an RR of 1.4 (CI=0.79-2.35) for total hypercholesterolemia and an RR of 1.6 (CI=0.75-3.71) for hypertriglyceridemia.
The antioxidant capital is reduced in type 2 diabetics, especially in dyslipidaemia conditions. Hygienic dietary measures and supplementation with trace elements such as zinc should prevent the complications of oxidative stress in diabetics.
Mechanization Assessment of Field Operations for Production of Sugar Cane in the White Nile Area-Sudan
Authors: Dahab Mohamed Hassan , Bakheit Salma Ishag S. , Abdallah Omer A. , Hamad Salih F. E. 
Published: June 2023

There are many types of machines and implements used for field operations and production of field crops such as sugar cane in the White Nile area of Sudan. Therefore the main objective of this study is to assess the mechanization used in the field operations for production of sugar cane crop. This study was based on data collected from the field operations and recorded information from the two sugar companies in the area. The field operations included, the up-rooting, harrowing, reharowing, leveling, ridging, planting, fertilization, spraying and harvesting. The measured parameters were the work rate of machinery, power requirement and the cost of mechanization of field operations. The actual field data was compared with the calculated ones. Some correjation regression analysis was carried out. The results showed that the calculated rate of work was positively correlated to the actual rate of work, speed and width of cut (r = 0.99). The highest calculated rate of work was for spraying operation as 36.2 fed/hr, while the lowest was for harvesting as 2.1 fed/hr. Most of the calculated rates of work were lower than the actual ones. Power requirements were found to increase with the weight of machines. Generally the calculated power requirements were lower than actual ones and the correlation between the machine weight (KN) and the actual power (kW) used for field operation was positive (r = 0.83). The highest calculated power requirement was recorded for the harvester as 350 kW whereas the lowest was for the fertilizer as 32.7 kW. The highest mechanization cost was for harvesting field operation as 253.4 $/hr and was mainly due to the higher cost of power requirement, while the lowest was for leveling operation as 25.8 $/hr. It was concluded that although most of the field operations are well mechanized, yet the power source and requirements for some operations to be reviewed to match the size and type of machinery used, to reduce costs of field operations and production and to protect the enviroment.
Evaluation of Out-of-Pocket Costs and Treatment Intensification With an SGLT2 Inhibitor or GLP-1 RA in Patients With Type 2 Diabetes and Cardiovascular Disease
Authors: Luo Jing , Feldman Robert , Callaway Kim Katherine , Rothenberger Scott , Korytkowski Mary , Hernandez Inmaculada , Gellad Walid F. 
Published: June 2023

ImportanceThe latest guidelines continue to recommend sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for patients with type 2 diabetes (T2D) and established cardiovascular disease (CVD). Despite this, overall use of these 2 drug classes has been suboptimal.ObjectiveTo assess the association of high out-of-pocket (OOP) costs and the initiation of an SGLT2 inhibitor or GLP-1 RA among adults with T2D and established CVD who are treated with metformin-treated.Design, Setting, and ParticipantsThis retrospective cohort study used 2017 to 2021 data from the Optum deidentified Clinformatics Data Mart Database. Each individual in the cohort was categorized into quartiles of OOP costs for a 1-month supply of SGLT2 inhibitor and GLP-1 RA based on their health plan assignment. Data were analyzed from April 2021 to October 2022.ExposuresOOP cost for SGLT2 inhibitors and GLP-1 RA.Main Outcomes and MeasuresThe primary outcome was treatment intensification, defined as a new dispensing (ie, initiation) of either an SGLT2 inhibitor or GLP-1 RA, among patients with T2D previously treated with metformin monotherapy. For each drug class separately, Cox proportional hazards models were used to adjust for demographic, clinical, plan, clinician, and laboratory characteristics to estimate the hazard ratios of treatment intensification comparing the highest vs the lowest quartile of OOP costs.ResultsOur cohort included 80 807 adult patients (mean [SD] age, 72 [9.5] years, 45 129 [55.8%] male; 71 128 [88%] were insured with Medicare Advantage) with T2D and established CVD on metformin monotherapy. Patients were followed for a median (IQR) of 1080 days (528 to 1337). The mean (SD) of OOP costs in the highest vs lowest quartile was $118 [32] vs $25 [12] for GLP-1 RA, and $91 [25] vs $23 [9] for SGLT2 inhibitors. Compared with patients in plans with the lowest quartile (Q1) of OOP costs, patients in plans with the highest quartile (Q4) of costs were less likely to initiate a GLP-1 RA (adjusted HR, 0.87 [95% CI, 0.78 to 0.97]) or an SGLT2 inhibitor (adjusted HR, 0.80 [95% CI, 0.73 to 0.88]). The median (IQR) number of days to initiating a GLP-1 RA was 481 (207-820) days in Q1 and 556 (237-917) days in Q4 of OOP costs and 520 (193-876) days in Q1 vs 685 (309-1017) days in Q4 for SGLT2 inhibitors.Conclusions and RelevanceIn this cohort study of more than 80 000 older adults with T2D and established CVD covered by Medicare Advantage and commercial plans, those in the highest quartile of OOP cost were 13% and 20% less likely to initiate a GLP-1 RA or SGLT2 inhibitor, respectively, when compared with those in the lowest quartile of OOP costs.
Self‐Assembly of Organelle‐Localized Neuropeptides Triggers Intrinsic Apoptosis Against Breast Cancer
Authors: Ge Xiaojiao , Cao Yi , Zhu Xueli , Yuan Bo , He Lulu , Wu Aiguo , Li Juan 
Published: June 2023

AbstractBiosynthesis has become a diverse toolbox for the development of bioactive molecules and materials, particularly for enzyme‐induced modification and assembly of peptides. However, intracellular spatiotemporal regulation of artificial biomolecular aggregates based on neuropeptide remains challenging. Here, an enzyme responsive precursor (Y1L‐KGRR‐FF‐IR) is developed based on the neuropeptide Y Y1 receptor ligand, which self‐assembles into nanoscale assemblies in the lysosomes and subsequently has an appreciable destructive effect on the mitochondria and cytoskeleton, resulting in breast cancer cell apoptosis. More importantly, in vivo studies reveal that Y1L‐KGRR‐FF‐IR has a good therapeutic effect, reduces breast cancer tumor volume and generates excellent tracer efficacy in lung metastasis models. This study provides a novel strategy for stepwise targeting and precise regulation of tumor growth inhibition through functional neuropeptide Y‐based artificial aggregates for intracellular spatiotemporal regulation.
An Exciplex‐Based Light‐Emission Pathway for Solution‐State Electrochemiluminescent Devices
Authors: Moon Chang‐Ki , Butscher Julian F. , Gather Malte C. 
Published: June 2023

AbstractElectrochemiluminescence (ECL) allows the design of unique light‐emitting devices that use organic semiconductors in a liquid or gel state, which allows for simpler and more sustainable device fabrication and facilitates unconventional device form‐factors. Compared to solid‐state organic LEDs, ECL devices (ECLDs) have attracted less attention due to their currently much lower performance. ECLD operation is typically based on an annihilation pathway that involves electron transfer between reduced and oxidized luminophore species; the intermediate radical ions produced during annihilation dramatically reduce device stability. Here, the effects of radical ions are mitigated by an exciplex formation pathway and a remarkable improvement in luminance, luminous efficacy, and operational lifetime is demonstrated. Electron donor and acceptor molecules are dissolved at high concentrations and recombined as an exciplex upon their oxidization/reduction. The exciplex then transfers its energy to a nearby dye, allowing the dye to emit light without undergoing oxidation/reduction. Furthermore, the application of a mesoporous TiO2 electrode increases the contact area and hence the number of molecules participating in ECL , thereby obtaining devices with a very high luminance of 3790 cd m−2 and a 30‐fold improved operational lifetime. This study paves the way for the development of ECLDs into highly versatile light sources.
Self‐Assembly of 0D/3D Perovskite Bi‐Layer from a Micro‐Emulsion Ink
Authors: Hou Yuchen , Wu Haodong , Yoon Jungjin , Zheng Luyao , Yang Dong , Ye Tao , Wang Ke , Wang Kai , Priya Shashank 
Published: June 2023

Abstract2D/3D bilayer perovskite synthesized using sequential deposition methods has shown effectiveness in enhancing the stability of perovskite solar devices. However, these approaches present several limitations such as uncontrolled chemical processes, disordered interfacial states, and microscale heterogeneities that can chemically, structurally, and electronically compromise the performance of solar modules. Here, this work demonstrates an emulsion‐based self‐assembly approach using natural lipid biomolecules in a nonionic solution system to form a 0D/3D bilayer structure. The new capping layer is composed of 0D‐entity nanoparticles of perovskite encapsulated by a hydrophobic lipid membrane, analogous to a cell structure, formed through a molecular self‐assembly process. This 0D layer provides a strong water repellent characteristics, optimum interface microstructure, and excellent homogeneity that drives significant enhancement in stability. Solar modules with a large active area of 70 cm2 fabricated using films comprising of 0D/3D bilayer structure are found to show consistent efficiency of >19% for 2800 h of continuous illumination in the air (60% relative humidity). This emulsion‐based self‐assembly approach is expected to have a transformative impact on the design and development of stable perovskite‐based devices.
The dry‐to‐wet transition of fiber networks—Return to mechanical stability
Authors: Bergström Per , Hanson Charlotta , Ström Henrik , Sasic Srdjan 
Published: June 2023

AbstractIn this article, we provide a comprehensive experimental, numerical, and theoretical explanation of the dry‐to‐wet transition of nonbonded fiber networks made of natural fibers. Given that the main functionality of many common products consisting of fluff pulp fiber networks requires absorption of liquids, we focus on understanding the solid volume fraction transition from a dry to a wet state as a crucial component for controlling properties such as permeability and capillary pressure, on which product function eventually depends. From studying the wetting of fluff pulp fiber networks with a distribution of fiber lengths, we show that the change in the solid volume fraction going from dry to wet state is driven by the disappearance of fiber–fiber adhesion. The mechanically stable state to which the network transitions is independent of its prior dry solid volume fraction and predetermined primarily by the fiber aspect ratio.
Characteristics of resting state functional connectivity of motor cortex of high fitness level college students: Experimental evidence from functional near infrared spectroscopy (fNIRS)
Authors: Li Wenyi , Zhang Qi , Yang Rui , Liu Bin , Chen Gonghe , Wang Bingyang , Xu Taiyu , Chen Jun , Zhou Xuxue , Wen Shilin 
Published: June 2023

AbstractObjectiveThis study inspects difference of resting state functional connectivity (RSFC) of motor cortex between athletes and ordinary college students and the test‐retest reliability of RSFC.MethodsTwenty high fitness level college students (high fitness group) and 20 ordinary college students (control group) were recruited. The motor cortical blood oxygen signals in resting states were monitored by functional near infrared spectroscopy (fNIRS). RSFCs of brain signals were preprocessed and calculated by FC‐NIRS software. RSFC results of test‐retest reliability were evaluated by intra‐class correlation coefficient (ICC).ResultsTotal RSFC (HbO signal) was significantly different between high fitness group (0.62 ± 0.04) and low fitness group (0.81 ± 0.04) (p < .05). Significant differences were found between the groups (HbO signal) in 50 edges among the 190 edges of motor cortex (14 edges after FDR corrected). At three hemoglobin concentrations, mean of group‐level ICC (C, 1) for total RSFC in two groups was 0.40 ± 0.10, whereas the mean of group‐level ICC (C, k) was 0.57 ± 0.11, depicting “fair” reliability. The mean of group‐level ICC (C, 1) of 190 “edges” was 0.88 ± 0.06, whereas mean of ICC (C, k) was 0.94 ± 0.03, exhibiting “excellent” reliability.ConclusionFitness level is the factor causing specific changes in RSFC strength of motor cortex that can be utilized as biomarker for evaluating the fitness level.
Customer‐driven sustainable business practices and their relationships with environmental and business performance—Insights from the European shipping industry
Authors: Raza Zeeshan , Woxenius Johan 
Published: June 2023

AbstractUnderstanding and meeting stakeholder demands for sustainability while striving for improved business performance (BP) presents a significant challenge. The shipping industry has been relatively slow in its sustainability efforts. However, it faces mounting pressure from various stakeholders, particularly customers (i.e., shippers directly or via logistics service providers), who increasingly demand reduced emissions from shipping operations. Consequently, environmental performance (EP) has become a key criterion in awarding shipping tenders, prompting shipping firms to adopt sustainable business practices (SBP). This study aims to investigate the relationships between customers' expectations (CE), the adoption of SBP and the EP and BP of European shipping companies. Structural equation modelling was employed to analyse the interrelationships among CE, SBP, EP and BP. The findings indicate a positive association between CE and the adoption of SBP, which in turn enhances EP and BP. Managers are encouraged to proactively allocate resources towards implementing SBP, as this not only improves EP but also enables better responsiveness to stakeholders' expectations, leading to increased profitability, customer satisfaction and corporate image. These outcomes yield benefits for all stakeholders involved in the European freight transport ecosystem.
Construction of a prognostic model for triple‐negative breast cancer based on immune‐related genes, and associations between the tumor immune microenvironment and immunological therapy
Authors: Zhu Yue , Tao Lin‐Feng , Liu Jin‐Yan , Wang Yi‐Xuan , Huang Hai , Jiang Yan‐Nan , Qian Wei‐Feng 
Published: June 2023

AbstractBackgroundTriple‐negative breast cancer (TNBC) is the subtype of breast cancer with the worst prognosis, and it is highly heterogeneous. There is growing evidence that the tumor immune microenvironment (TIME) plays a crucial role in tumor development, maintenance, and treatment responses. Notably however, the full effects of the TIME on prognosis, TIME characteristics, and immunotherapy responses in TNBC patients have not been fully elucidated.MethodsGene Expression Omnibus and The Cancer Genome Atlas data were used to data analysis. Single‐cell sequencing and tissue microarray analysis were used to investigate gene expression. The concentrations and distributions of immune cell types were determined and analyzed using the CIBERSORT strategy. Tumor immune dysfunction and exclusion score and the IMvigor210 cohort were used to estimate the sensitivity of TNBC patients with different prognostic statuses to immune checkpoint treatment.ResultsFive immune‐related genes associated with TNBC prognosis (IL6ST, NR2F1, CKLF, TCF7L2, and HSPA2) was identified and a prognostic evaluation model was constructed based on those genes. The respective areas under the curve of the prognostic nomogram model at 3 and 5 years were 0.791 and 0.859. The group with a lower nomogram score, with a better prognosis survival status and clinical treatment benefit rate.ConclusionA prognostic model for TNBC that was closely related to the immune landscape and therapeutic responses was constructed. This model may help clinicians to make more precise and personalized treatment decisions pertaining to TNBC patients.