bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paracas y Chavín: variaciones sobre un tema longevo
Authors: Kaulicke Peter 
Published: May 2023

En este trabajo, se presenta y se discute los diferentes enfoques interpretativos relacionados con las tempranas evidencias de cultura material en la costa sur, y sus comparaciones con aquellas del norte desde la formulación original de Tello. Estas propuestas llevaron a hipótesis variadas y, a menudo, poco convincentes, debido a problemas de terminología y de metodología. A ello se suma la escasa e incompleta presentación de contextos respectivos recuperados en excavaciones. Se enfatiza los resultados de trabajos recientes en el Río Grande de Nazca, con el afán de ajustar las cronologías regionales, así como el carácter de transiciones y la formación de esferas de interacción más amplias.
Investigaciones arqueológicas en Catalina Huanca, un asentamiento de la sociedad Lima del Horizonte Medio
Authors: Maquera Erik , Esteban Milagros 
Published: May 2023

Se presenta una introducción del sitio Catalina Huanca así como los resultados de las investigaciones realizadas en los Montículos 6 y 7 durante los años 2006-2008. Tales intervenciones nos han permitido identicar el desarrollo de procesos políticos locales. Así, alrededor del año 550 d.C., la sociedad Lima inicia la construcción planicada de un extenso centro público en el valle medio del Rímac, el cual implicó una enorme inversión de trabajo y organización. El análisis de la secuencia arquitectónica del Montículo 7 nos indica que durante un trascurso de 150 años, los edicios del asentamiento fueron renovados continuamente, reproduciendo las plantas arquitectónicas originales y por lo tanto los mismos principios que sustentaban la ideología del poder local. Luego, hacia los años 700-750 d.C. los edicios son sepultados y abandonados tras eventos de sacricios humanos, después de lo cual se registran gruesos estratos de limo.A partir del 750 d.C. uno de los montículos del asentamiento (Montículo 6) es reutilizado como cementerio de una población cuya cultura material se encuentra asociada al fenómeno wari.
Informal Practices of Localizing Open Educational Resources in Ghana
Authors: Bradshaw Emily , McDonald Jason K. 
Published: May 2023

Research on the use of Open Educational Resources (OER) often notes the potential benefits for users to revise, reuse, and remix OER to localize it for specific learners. However, a gap in the literature exists in terms of research that explores how this localization occurs in practice. This is a significant gap given the current flow of OER from higher-income countries in the Global North to lower-income countries in the Global South (King et al., 2018). This study explores how OER from one area of the world is localized when it is used in a different cultural context.
Findings indicated complex encounters with decontextualized content and a variety of localization practices. Participants experienced challenges with technology due to low bandwidth and hardware problems, as well as language problems given Ghana’s history of colonial rule. Native speakers of Twi are less proficient reading Twi than their national language, English. As facilitators worked to overcome these challenges, they were most likely to informally localize content in intuitive ways during the class based on students’ needs. Informal, in-the-moment practices included translating content into Twi, persisting through technological challenges, using local stories and pictures, localizing through discussion, and teaching responsively. These findings have implications for designers to design collaboratively with technological and linguistic flexibility for localization. More research on the practice of OER localization would refine our understanding of how OER is localized and what barriers and affordances exist to this practice.
How Instructors’ TPACK Developed During Emergency Remote Teaching: Evidence From Instructors in Faculties of Education
Authors: Çakıroğlu Ünal , Aydın Merve , Bahadır Kurtoğlu Yılmaz , Cebeci Ümit 
Published: May 2023

Higher education instructors tried to find best teaching ways during the pandemic. Instructors who were faced with emergency situations used various technologies to deliver their courses. In this study, an online survey was used to ask instructors about their experiences regarding their development of technological pedagogical content knowledge (TPACK) during emergency remote teaching (ERT); 231 responses were received from instructors from faculties of education. The survey was a five-point Likert-type scale include the dimensions of pedagogical knowledge, pedagogical knowledge, technological knowledge, technological content knowledge, pedagogical content knowledge, technological pedagogical knowledge, and technological pedagogical content knowledge. Instructors rated their own non-technological knowledge (pedagogical knowledge, content knowledge, and pedagogical content knowledge) relatively higher than their knowledge including technology (technological knowledge, technological pedagogical knowledge, and technological content knowledge). The findings indicate that instructors had a consistently high level of perceived knowledge in all TPACK dimensions. Regarding developments in instructors’ TPACK, several suggestions were made, including novel technologies and pedagogies specialized for ERT.
Moringa oleifera Leaf Ethanol Extract Inhibits Toxoplasma gondii Tachyzoites Replication
Authors: Wihanto Laura , Waworuntu Gladdy Lysias , Tedyanto Cecilia Putri , Puspitasari Heni 
Published: May 2023

The various infection routes of Toxoplasma gondii that are close to daily life strongly support the incidence of toxoplasmosis. The emergence of drug-resistant Toxoplasma gondii strains raises future concerns. Moringa leaf ethanol extract has been shown to have several anti-pathogen activities, which could have an anti-Toxoplasma effect. This research was conducted to analyze the anti-Toxoplasma effect of moringa leaf ethanol extract against tachyzoites replication in Toxoplasma gondii and the correlation between extract doses with the number of tachyzoites. Mice were divided into five groups. The negative control group (Group I) received CMC-Na solution. The positive control group (Group II) received spiramycin 100 mg/kg BW. The treatment groups received moringa leaf ethanol extract 250 mg/kg BW (group III), 500 mg/kg BW (group IV), and 1000 mg/kg BW (group V), respectively. Mice were injected with 1 x 105 tachyzoites/0.1 mL/mice intraperitoneally on the first day. Moringa leaf ethanol extract and spiramycin were given orally once daily for three days. The number of tachyzoites in the intraperitoneal fluid was calculated on the fifth day. The results have shown that there were significantly lower differences (P < 0.05) in group IV (P = 0.021) and group V (P = 0.022) compared to group I. There was also a significant negative correlation between the extract doses and the number of tachyzoites (P = 0.000; r = -0.781). Moringa oleifera leaf ethanol extract has an anti-Toxoplasma effect by inhibiting the tachyzoite replication at 500 mg/kg BW and 1000 mg/kg BW.
PENGEMBANGAN ALAT PENILAIAN PRAKTIK RESERVATION CONVERSATION MENGGUNAKAN APLIKASI VE-RUBRIC DI SEKOLAH MENENGAH KEJURUAN AKOMODASI PERHOTELAN
Authors: Salsabila Salsabila , Rohaeni Neni , Jubaedah Yoyoh 
Published: May 2023

Penelitian ini dilatarbelakangi oleh penggunaan alat penilaian di sekolah yang masih dilakukan secara konvensional (paper-based). Dalam perkembangan teknologi di dunia pendidikan yang berimplikasi pada pengembangan penilaian. Kondisi tersebut menunjukkan perlunya pengembangan rubrik penilaian berbasis digital. Penelitian ini bertujuan untuk mengembangkan alat penilaian praktik Reservation Conversation menggunakan VE. Rubric di Sekolah Menengah Kejuruan (SMK). Metode yang digunakan dalam melakukan penelitian ini adalah deskriptif dengan pendekatan ADDIE (Analysis, Design, Development, Implementation, and Evaluation). Teknik pengumpulan data dilakukan dengan observasi, wawancara, expert judgement, serta angket respon kepada guru mata pelajaran front office di SMK. Hasil validasi pengembangan alat penilaian adalah: (1) ahli penilaian menilai sangat layak dengan persentase sebesar (85,7%). (2) ahli materi menilai sangat layak dengan persentase sebesar (97,5%). Implementasi dilakukan dengan uji coba terbatas pada 6 orang peserta didik di SMK. Evaluasi diisi dengan kegiatan pengisian angket kuesioner usability respon guru terhadap implementasi yang telah dilakukan, dengan hasil guru menilai layak dengan persentase (79,3 %). Berdasarkan hasil perolehan data menunjukkan bahwa alat penilaian praktik Reservation Conversation menggunakan VE. Rubric layak digunakan.
Sexo, amor y palabras
Authors: Ogea Pozo Maria del Mar , Botella Tejera Carla 
Published: May 2023

Las series de adolescentes o teen series llevan ya años acompañándonos y representando escenas y situaciones con las que se identifican jóvenes y adolescentes. Sin embargo, además de identificarse con dichas escenas, también lo hacen con el léxico y expresiones que emplean sus protagonistas. De esta manera, recrean una especie de jerga juvenil que, entre otros temas de interés para sus receptores, cubre el de la relaciones sexuales y amorosas. Así, través de la traducción, estas series llegan distintos países y espectadores muy diversos. En el caso del doblaje, a pesar de partir de una oralidad prefabricada, los diálogos tienen que ser lo más naturales posibles para que resulten verosímiles para el público meta. Por eso, el léxico relacionado con las relaciones sexuales y amorosas en español deberá intentar producir en la nueva audiencia las mismas sensaciones provocadas a los de la versión original.
Este artículo estudia doce episodios de tres series de adolescentes de los últimos años (2019-2022) tanto en su versión original como en su versión doblada al español con el objetivo de analizar las dificultades de traducción de este tipo de léxico, su posible caducidad y censura recibida, para llegar a establecer una taxonomía propia de clasificación del léxico de las relaciones. Así, llegamos a la conclusión de que se da una cifra muy similar de términos de esta jerga en las series ambos idiomas, a pesar de darse algunas diferencias interesantes, pero que, en general, el doblaje de las tres permite una experiencia pareja a la que viven los espectadores de la versión original.
DETERMINANTS OF THE INTENTION TO PAY ZAKAT ONLINE: THE CASE OF INDONESIA
Authors: Kasri Rahmatina A. , Sosianti Meis Winih 
Published: May 2023

In this paper, we extend the Unified Theory of Acceptance and Use of Technology (UTAUT) model to examine factors that shape the intention of Muslims in Indonesia to pay zakat online. In the analysis, we include performance expectancy, effort expectancy, social influence, facilitating conditions, trust in zakat institutions, zakat literacy and Islamic religiosity as potential factors in the analysis. The study employs primary data gathered from 734 respondents and uses the Structural Equation Modeling method for data analysis. The main result shows that facilitating conditions, performance expectancy, trust in zakat institutions, social influence, and zakat literacy influence the intention to pay zakat online. However, effort expectancy and Islamic religiosity turn out to be insignificant determinants of the intention to pay online zakat. The findings suggest that zakat stakeholders must enhance trust and intensify education about zakat. Zakat organizations must also improve the quality of the online zakat system, highlight the benefits of zakat online, and optimize the use of social media to increase zakat collection through digital channels.
Comparing patient-reported outcome measures for pain in women with pelvic floor disorders pre- and post-surgical management: A systematic review protocol
Authors: Hoque Sheymonti Shahreen , Ahern Susannah , O’Connell Helen E. , Romero Lorena , Ruseckaite Rasa 
Published: May 2023

Abstract
Background: Pelvic floor disorders including stress urinary incontinence and/or pelvic organ prolapse affect more than 50% of Australian women. Pelvic floor disorders cause a wide range of symptoms including painful urination, constipation and lower back pain. Previous surgical treatment may also affect the presence of pelvic symptoms, including pelvic pain, vaginal pain and dyspareunia which can lead to poor health-related quality of life. Patient-reported outcome measures are an important way of examining the health-related quality of life of women with pelvic floor disorders pre- and post-surgery, however, there are very few patient-reported outcome measures measuring this important domain of pelvic or vaginal pain. This paper aims to identify and compare patient-reported outcome measures for pain in women with a pelvic floor disorder in the existing literature, as well as to explore and highlight the gaps regarding the development and validation of a pain instrument. This review also aims to describe the modes and methods for administration of the instruments.
Methods: This review will be conducted based on the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols guideline and checklist. Ovid MEDLINE, Ovid Embase, CINAHL Plus and Ovid PsychInfo databases as well as the grey literature will be searched for studies that use, develop or implement patient-reported outcome measures for pain as an HRQoL outcome in adult women with a pelvic floor disorder pre- and post-surgery. Studies reporting on the psychometric properties of patient-reported outcome measures will be included. An independent researcher will screen the title and abstracts of the studies. Two independent researchers will undertake full-text review and any disagreements will be resolved through discussion and consensus. The final selected studies will undergo data extraction, qualitative analysis and synthesis.
Discussion: The findings of this review will assist with the development and validation of new pain-specific patient-reported outcome measures for women with pelvic floor disorder in the registry or clinical practice.
Trial registration: CRD42022319663
Molecular surveillance leads to the first detection of Anopheles stephensi in Kenya.
Authors: Ochomo Eric O. , Milanoi Sylvia , Abong’o Bernard , Onyango Brenda , Muchoki Margaret , Omoke Diana , Olanga Evelyne , Njoroge Laban , Juma Elijah , Otieno James Dan , Matoke-Muhia Damaris , Kamau Luna , Rafferty Cristina , Gimnig John E. , Shieshia Mildred , Wacira Daniel , Mwangangi Joseph , Maia Marta , Chege Charles , Omar Ahmeddin , Rono Martin K , Abel Lucy , Obala Andrew , O’Meara Wendy Prudhomme , Mbogo Charles , Kariuki Lenson 
Published: May 2023

Abstract
Anopheles stephensi is an invasive malaria vector recently reported in Djibouti (2012), Ethiopia, Sudan (2019), Somalia (2019) and most recently Nigeria (2020). The World Health Organization (WHO) has called on all countries to scale up surveillance efforts to detect and report invasion by this vector and institute appropriate and effective control mechanisms. In Kenya, the Division for National Malaria Program (DNMP) conduct entomological surveillance in counties at risk of An. stephensi invasion. These efforts were supported by molecular surveillance of all sampled Anopheles mosquitoes from other studies conducted by the Kenya Medical Research Institute (KEMRI) to identify An. stephensi. In this article, we report the first detection of An. stephensi in Marsabit and Turkana Counties using PCR and confirmed by sequencing and morphological identification. This detection shows the urgent need for intensified surveillance to determine its occurrence and distribution and develop tailored approaches towards control to prevent further spread.
Impact of Body Mass Index on Pathological Response after Neoadjuvant Chemotherapy: Results from the I-SPY 2 trial
Authors: Wang Haiyun , Yee Douglas , Potter David , Jewett Patricia , Yau Christina , Beckwith Heather , Watson Allison , O'Grady Nicholas , Wilson Amy , Brain Susie , Pohlmann Paula , Blaes Anne 
Published: May 2023

Abstract
Purpose
Increased body mass index (BMI) has been associated with poor outcomes in women with breast cancer. We evaluated the association between BMI and pathological complete response (pCR) in the I-SPY 2 trial.
Methods
978 patientsenrolled in the I-SPY 2 trial 3/2010-11/2016 and had a recorded baseline BMI prior to treatment were included in the analysis. Tumor subtypes were defined by hormone receptor and HER2 status. Pretreatment BMI was categorized as obese (BMI≥30 kg/m2), overweight (25≤BMI < 30 kg/m2), and normal/underweight (< 25 kg/m2). pCR was defined as elimination of detectable invasive cancer in the breast and lymph nodes (ypT0/Tis and ypN0) at the time of surgery. Logistic regression analysis was used to determine associations between BMI and pCR. Event-free survival (EFS) and overall survival (OS) between different BMI categories were examined using Cox proportional hazards regression.
Results
The median age in the study population was 49 years. pCR rates were 32.8% in normal/underweight, 31.4% in overweight, and 32.5% in obese patients. In univariable analysis, there was no significant difference in pCR with BMI. In multivariable analysis adjusted for race/ethnicity, age, menopausal status, breast cancer subtype, and clinical stage, there was no significant difference in pCR after neoadjuvant chemotherapy for obese compared with normal/underweight patients (OR = 1.1, 95% CI: 0.68–1.63, p = 0.83), and for overweight compared with normal/underweight (OR = 1, 95% CI: 0.64–1.47, p = 0.88). We tested for potential interaction between BMI and breast cancer subtype; however, the interaction was not significant in the multivariable model (p = 0.09). Multivariate Cox regression showed there was no difference in EFS (p = 0.81) or OS (p = 0.52) between obese, overweight, and normal/underweight breast cancer patients with a median follow-up time of 3.8 years.
Conclusions
We found no difference in pCR rates by BMI with actual body weight based neoadjuvant chemotherapy in this biologically high-risk breast cancer population in the I-SPY2 trial.
Measuring Concordance and Discordance between Individual Characteristics and Neighborhood-level Social Determinants of Health
Authors: Ngai Ka Ming Gordon , Maroko Andrew , Bilal Saadiyah , Gordon Lauren , Richardson Lynne D 
Published: May 2023

Abstract
Background: People have both individual and neighborhood level social determinants that may confer health risks or health benefits. While these are often aligned, this is not always the case. An affluent individual may live in a neighborhood with a high median income (concordance) or an affluent individual may live in a neighborhood with a low median income (discordance).Methods: We propose a method to operationalize the concepts of concordance and discordance between individual-level and neighborhood-level social determinants and provide two examples. We first consider a factor that is measured with a continuous variable–household income. We then consider race/ethnicity—a categorical variable. To illustrate the proposed method, we apply our operational definitions to a small dataset that contains self-reported individual data paired with geocoded publicly available neighborhood-level data based on residential address.Results: In our cohort, 38% of participants lived in neighborhoods that were racial/ethnically concordant; 23% of participants in neighborhood that were racial/ethnically discordant, and 39% of participants in neighborhoods that were Neutral.Conclusion: We propose an approach to defining the concepts of concordance and discordance of individual characteristics with neighborhood-level social determinants. Our proposed approach will enable more robust investigations of social determinants of health and their impact on health. Such investigations are needed to inform the growing use of social determinants of health data from various sources for a variety of purposes.
Evaluation of ERA5 and Dynamical Downscaling for Surface Energy Balance Modeling at Mountain Glaciers in Western Canada
Authors: Draeger Christina , Radic Valentina , White Rachel H. , Tessema Mekdes Ayalew 
Published: May 2023

Abstract
Regional-scale surface energy balance (SEB) models of glacier melt require forcing by coarse-gridded data from reanalysis and/or global climate models that need to be downscaled to glacier scale. As on-glacier meteorological observations are rare, it generally remains unknown how exact the reanalysis and downscaled data are for the local-scale SEB modeling. We address this question by evaluating the performance of reanalysis from the European Centre for Medium-Range Weather Forecasts (ERA5 and ERA5-Land reanalysis), with and without downscaling, at four glaciers in Western Canada with available on- glacier meteorological measurements collected over different summer seasons. We dynamically downscale ERA5 with the Weather Research and Forecasting (WRF) model at 3.3 km and 1.1 km grid spacing. We find that the SEB model, forced separately with the observations and the two reanalyses, yields <10 % difference in simulated total melt energy and shows strong correlations (>0.79) in simulated timeseries of daily melt energy at each site. The good performance of the reanalysis-derived melt energy is partly due to cancellation of biases between overestimated incoming shortwave radiation and substantially underestimated wind speed and subsequently turbulent heat fluxes. Downscaling with WRF improves the simulation of wind speed, while other meteorological variables show similar performance to ERA5 without downscaling. The choice of WRF physics parameterization schemes is shown to have a relatively large impact on the simulations of SEB components, but a smaller impact on the modeled total melt energy. The results increase our confidence in dynamical downscaling with WRF for long-term glacier melt modeling in this region.
In vitro and in vivo antileishmanial activity of thioridazine
Authors: Rodríguez Sergio Sifontes , Mollineda-Diogo Niurka , Monzote-Fidalgo Lianet , Escalona-Montaño Alma Reyna , García-Trevijano José Antonio Escario , Aguirre-García María Magdalena , Meneses-Marcel Alfredo Irenaldo 
Published: May 2023

Abstract
Leishmaniasis is a neglected disease with high prevalence and incidence in tropical and subtropical areas. Existing drugs are limited due to cost, toxicity, declining efficacy and unavailability in endemic places. Drug repurposing has established as an efficient way for the discovery of drugs for a variety of diseases.
Purpose: The objective of the present work was testing the antileishmanial activity of thioridazine, an antipsychotic agent with demonstrated effect against other intracellular pathogens.
Methods: The cytotoxicity for mouse peritoneal macrophages as well as the activity against Leishmania amazonensis, Leishmania mexicana and Leishmania major promastigotes and intracellular amastigotes, as well as in a mouse model of cutaneous leishmaniasis were assessed.
Results: Thioridazine inhibited the in vitro proliferation of promastigotes (50 % inhibitory concentration -IC50- values in the range of 0.73 µM to 3.8 µM against L. amazonensis, L. mexicana and L. major) and intracellular amastigotes (IC50 values of 1.27 µM to 4.4 µM for the same species). In contrast, in mouse peritoneal macrophages, the 50 % cytotoxic concentration was 24.0 ± 1.89 µM. Thioridazine inhibited the growth of cutaneous lesions and reduced the number of parasites in the infected tissue of mice. The dose of thioridazine that inhibited lesion development by 50 % compared to controls was 23.3 ± 3.1 mg/kg and in terms of parasite load it was 11.1 ± 0.97 mg/kg.
Conclusions: Thioridazine was effective against the promastigote and intracellular amastigote stages of three Leishmania species and in a mouse model of cutaneous leishmaniasis, supporting the potential repurposing of this drug as an antileishmanial agent.