bluuebunny/crossref_metadata_2025_split huggingface dataset:
System Dynamics Model of Decentralized Household Electricity Storage Implementation. Case Study of Latvia
Authors: Gravelsins Armands , Atvare Erlanda , Kudurs Edgars , Kubule Anna , Blumberga Dagnija 
Published: August 2023

Increasing of renewable energy share in total energy production is a direction that leads towards European Union’s aims of carbon neutrality by 2050, as well as increases energy self-sufficiency and independence. Some of the main challenges to increase renewable energy share while providing efficient and secure energy supply are related to optimization and profitability of de-centralized energy production systems. Integration of energy storage systems in addition to decentralized renewable energy production, for example, by solar panels, leads to more effective electricity supply and smart energy solutions. The modelling of such complex dynamic system can be performed using system dynamics method. The aim of the article is to forecast the practice of electricity storage in Latvia in the coming decades. A system dynamics model predicting the implementation of battery storage in private households was created for the case study of Latvia. Modelling results reveal that under the right conditions for electricity price, investment costs and with the right policy interventions battery storage technologies combined with PV panels have high potential for utilization in household sector. Model results show that in baseline scenario with no additional policies up 21 422 households or 10.8 % of Latvian households could have combined PV and battery system installed in 2050. Moderate subsidy policy can help to increase this number up to 25 118.
Spread of Extended-Spectrum-β-Lactamase-Producing Pathogenic Escherichia coli Clonal Complex 10 in the Republic of Korea
Authors: Park Jungsun , Shin Eunkyung , Han Joohyun , Kang Wooju , Yoo Jaeil , Yoo Jung-sik , Roh Dong-Hyun , Kim Junyoung 
Published: August 2023

ESBL-producing E. coli is a growing public problem in healthcare settings and the community. Between 2009 and 2018, a total of 187 ESBL-producing pathogenic E. coli isolates were confirmed, and clonal complex (CC) 10 was the predominant clone. This study aimed to characterize ESBL-producing pathogenic E. coli CC10 strains obtained from diarrheal patients to improve the understanding of CC10 distribution in the Republic of Korea.
A total of 57 CC10 strains were selected for molecular characterizations, such as the identification of serotype, antibiotic resistance genes, genetic environments, plasmid profiles, and the genetic correlation between CC10 strains.
In the CC10 isolates, the most prevalent serotype was O25:H16, followed by O6:H16. ESBL genes were identified as blaCTX-M, and the most dominant ESBL gene was blaCTX-M-15 (56%) and blaCTX-M-14 (30%). Most blaCTX-M genes were located on plasmids, and these plasmid profiles were confirmed as IncB/O/K/Z, IncF, IncI1 and IncX1. The mobile elements located up-and down-stream mainly included ISEcp1 (complete or incomplete) and IS903 or orf477 were found, respectively. Phylogenetic analysis showed that the CC10 strains were genetically diverse and divided into several distinct lineages.
In this study, we found that CC10 ESBL-producing pathogenic E. coli has been steadily isolated; particularly, CTX-M-15-producing E. coli O25:H16 isolates were the major type related with distribution in CC10 clones during the last decade. Identification of ESBL-producing pathogenic E. coli CC10 isolates highlights the possibility of the emergence of resistant isolates with epidemic potential within this CC. Therefore, continuous monitoring will be conducted to prevent further spread of resistant ESBL-producing E. coli CC10 strains.
Continued Stabilization of a Cementless 3D-Printed Total Knee Arthroplasty
Authors: van der Lelij Thies J.N. , Marang-van de Mheen Perla J. , Kaptein Bart L. , Toksvig-Larsen Sören , Nelissen Rob G.H.H. 
Published: August 2023

Background:
Three-dimensional (3D) printing of highly porous orthopaedic implants aims to promote better osseointegration, thus preventing aseptic loosening. However, short-term radiostereometric analysis (RSA) after total knee arthroplasty (TKA) has shown higher initial migration of cementless 3D-printed tibial components compared with their cemented counterparts. Therefore, critical evaluation of longer-term tibial component migration is needed. We investigated migration of a cementless 3D-printed and a cemented tibial component with otherwise similar TKA design during 5 years of follow-up, particularly the progression in migration beyond 2 years postoperatively.

Methods:
Seventy-two patients were randomized to a cementless 3D-printed Triathlon Tritanium (Stryker) cruciate-retaining (CR) TKA or a cemented Triathlon CR (Stryker) TKA implant. Implant migration was evaluated with RSA at baseline and postoperatively at 3 months and at 1, 2, and 5 years. The maximum total point motion (MTPM) of the tibial component was compared between the groups at 5 years, and progression in migration was assessed between 2 and 5 years. Individual implants were classified as continuously migrating if the MTPM was ≥0.1 mm/year beyond 2 years postoperatively. Clinical scores were evaluated, and a linear mixed-effects model was used to analyze repeated measurements.

Results:
At 5 years, the mean MTPM was 0.66 mm (95% confidence interval [CI], 0.56 to 0.78 mm) for the cementless group and 0.53 mm (95% CI, 0.43 to 0.64 mm) for the cemented group (p = 0.09). Between 2 and 5 years, there was no progression in mean MTPM for the cementless group (0.02 mm; 95% CI, −0.06 to 0.10 mm) versus 0.07 mm (95% CI, 0.00 to 0.14) for the cemented group. One implant was continuously migrating in the cementless group, and 4 were continuously migrating in the cemented group. The clinical scores were comparable between the groups across the entire time of follow-up.

Conclusions:
No significant difference in mean migration was found at 5 years between the cementless and cemented TKA implants. Progression of tibial component migration was present beyond 2 years for the cemented implant, whereas the cementless implant remained stable after initial early migration.

Level of evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Surgical Management and Return to Activity of an Athlete with Traumatic Posterior Tibial Tendon Rupture and Associated Injuries
Authors: Protzuk Omar , Wyatt Phillip , Poulos Nicholas , O’Neill Conor , O’Connell Robert 
Published: August 2023

Case:
A 22-year-old athlete sustained a traumatic posterior tibial tendon (PTT) rupture with medial malleolus fracture and anterior tibial plafond chondral lesion during practice. He underwent PTT repair, ankle arthroscopy with microfracture, and medial malleolus open reduction and internal fixation with deltoid ligament repair. At 1 year postoperatively, the patient returned to activity excluding high-level competition.

Conclusion:
Anterior tibial chondral impaction injury with an avulsion fracture of the medial malleolus and PTT tear is effectively treated with a combined arthroscopic and open approach.
Low-Intensity Pulsed Ultrasound for Symptomatic Pseudarthrosis After Toe Fracture with Symphalangism
Authors: Shima Hiroaki , Togei Kosho , Hirai Yoshihiro , Tanaka Ken , Saito Atsunori , Yasuda Toshito , Neo Masashi 
Published: August 2023

Case:
Distal phalangeal fractures are often treated conservatively. However, some patients experience residual pain. We report 2 cases of patients who underwent low-intensity pulsed ultrasound (LIPUS) therapy for pseudarthrosis after fracture of the distal phalanx of the fifth toe with symphalangism. Both patients (female, 63 and 33-year-old, respectively) underwent conservative treatment with buddy-taping fixation; however, bone union failed, and LIPUS therapy was initiated. In both cases, bone union was achieved and pain resolved after 3 months.

Conclusion:
Bone union occasionally fails after conservative treatment of distal phalangeal fractures. LIPUS is a useful treatment of symptomatic pseudarthrosis after such fractures.
INFORMATION EFFICIENCY IN THE U.S. AND SHARIAH-COMPLAINT STOCKS IN MALAYSIA DURING COVID-19
Authors: Loang Ooi Kok 
Published: August 2023

This study examines the impact of analysts’ forecast of market liquidity and information efficiency in the U.S (developed) and Malaysia (emerging – Shariah-compliant stocks) before and during COVID-19. The results show that the analysts’ forecast is significant to the market liquidity in the pre-COVID period but its influence diminishes during the COVID-19. Moreover, the impact of the analysts’ forecast is significant in the upper quantiles (0.7 and 0.9 quantiles) of the U.S market and in the lower quantiles (0.1 and 0.3 quantiles) of Malaysia's Islamic market. Similarly, the buy-sell recommendations in the U.S market and all variables forecasted are significant before COVID-19. Both markets become inefficient during COVID-19, and analysts’ forecast is no longer correlated to information efficiency. These results inform practitioners and investors to inspect the market conditions and investor's behavior under market stress such as COVID-19, which has disrupted the international financial markets.
PURCHASE INTENTION OF HALAL LOCAL BEAUTY BRAND DURING COVID-19: THE ROLE OF INFLUENCERS’ CREDIBILITY AND HALAL AWARENESS
Authors: Tazlia Ismi , Nurfadilah Dety , Pratama Sasotya 
Published: August 2023

By applying the Stimulus-Organism-Response (SOR) model, this study investigates whether influencers’ credibility and halal awareness influence customer’s perceived value which, in turn, affects their purchase intention. Gathering data using an online survey and applying the SEM-PLS method, we find that influencers' credibility and halal awareness have a positive effect on the customer’s perceived value for local Indonesian halal beauty products. In addition, the perceived value also affects customers purchase interest. The results related to halal awareness emphasizes the role of halal certification in the customer’s purchase intention. This study provides valuable insight to the halal local beauty industry to improve the marketing strategy and contributes to the theoretical literature in the field of management and marketing.
Pilot-Scale Testing of Natural Gas Pipeline Monitoring Based on Phase-OTDR and Enhanced Scatter Optical Fiber Cable
Authors: Lalam Nageswara , Westbrook Paul , Naeem Khurram , Lu Ping , Ohodnicki Paul , Diemler Nathan , Buric Michael P. , Wright Ruishu 
Published: August 2023

Abstract
In this paper, we present the results of lab and pilot-scale testing of a continuously enhanced backscattering, or Rayleigh enhanced fiber cable that can improve distributed acoustic sensing performance. In addition, the Rayleigh-enhanced fiber is embedded within a tight buffered cable configuration to withstand and be compatible for field applications. The sensing fiber cable exhibits a Rayleigh enhancement of 13 dB compared to standard silica single-mode fiber while maintaining low attenuation of ≤0.4 dB/km. We built a phase-sensitive optical time domain reflectometry system to interrogate the enhanced backscattering fiber cable both in lab and pilot-scale tests. In the laboratory experiment, we analyzed the vibration performance of the enhanced backscattering fiber cable and compared it with the standard single-mode telecom fiber. Afterward, we field validated for natural gas pipeline vibration monitoring using a 4-inch diameter steel pipeline operating at a fixed pressure level of 1000 psi, and a flow rate of 5, 10, 15, and 20 ft/s. The feasibility of gas pipeline monitoring with the proposed enhanced backscattering fiber cable shows a substantial increase in vibration sensing performance. The pilot-scale testing results demonstrated in this paper enable pipeline operators to perform accurate flow monitoring, leak detection, third-party intrusion detection, and continuous pipeline ground movement.
Implementation of Reinspection Scheme in Skip-lot Sampling Plan Based on the Taguchi Process Capability Index
Authors: Suthersan Panneerselvam , Balamurali Saminathan 
Published: August 2023

Abstract
In several industries, skip-lot sampling plans are utilised to reduce the need for inspection when a product has a history of high quality. These plans are regarded as being economically beneficial as they help to reduce the expense of the final lots examination. In this paper, we propose a designing methodology of the skip-lot sampling plans including resampling based on the Taguchi process capability index. In order to satisfy both producer and consumer risk, the plan parameters for the proposed plan are set by minimising the average sample number. The effectiveness of the proposed plan is discussed by comparing with the existing sampling plans. Moreover, the data from amplified pressure sensors is used to discuss the real life application of the proposed plan.
Enzyme Mechanistic Studies of NMA1982, a Protein Tyrosine Phosphatase and Potential Virulence Factor in Neisseria meningitidis
Authors: Wu Shuangding , Coureuil Mathieu , Nassif Xavier , Tautz Lutz 
Published: August 2023

Abstract
Protein phosphorylation is an integral part of many cellular processes, not only in eukaryotes but also in bacteria. The discovery of both prokaryotic protein kinases and phosphatases has created interest in generating antibacterial therapeutics that target these enzymes. NMA1982 is a putative phosphatase from Neisseria meningitidis, the causative agent of meningitis and meningococcal septicemia. The overall fold of NMA1982 closely resembles that of protein tyrosine phosphatases (PTPs). However, the hallmark C(X)5R PTP signature motif, containing the catalytic cysteine and invariant arginine, is shorter by one amino acid in NMA1982. This has cast doubt about the catalytic mechanism of NMA1982 and its assignment to the PTP superfamily. Here, we demonstrate that NMA1982 indeed employs a catalytic mechanism that is specific to PTPs. Mutagenesis experiments, transition state inhibition, pH-dependence activity, and oxidative inactivation experiments all support that NMA1982 is a genuine PTP. Importantly, we show that NMA1982 is secreted by N. meningitidis, suggesting that this protein is a potential virulence factor. Future studies will need to address whether NMA1982 is indeed essential for N. meningitidis survival and virulence. Based on its unique active site conformation, NMA1982 may become a suitable target for developing selective antibacterial drugs.
The regimen based on trimethoprim/sulfamethoxazole combination of caspofungin and corticosteroids as the first-line therapy for non-HIV patients with severe pneumocystis jirovecii pneumonia：a retrospective research of a tertiary hospital
Authors: Li Hao , Lu Yihe , Tian Guoxin , Wu Yongxing , Chen Tianjun , Zhang Jiangwei , Hu Nan , Wang Xiaoning , Gao Lan , Yan Jinqi , Zhou Linjing , Shi Qindong 
Published: August 2023

Abstract
Background: Pneumocystis jirovecii pneumonia (PJP) is a life-threatening and severe disease in immunocompromised hosts. The synergic regimen based on sulfamethoxazole-trimethoprim (SMX-TMP) combination of caspofungin and glucocorticosteroid (GCS) may be a potential first-line therapy. Therefore, it is important to explore the efficacy and safety of this synergic therapy to treat non-HIV PJP patient.
Methods: We retrospectively analyzed the data of 38 patients with non-HIV PJP at the the First Affiliated Hospital of Xi’an Jiaotong University. Patients were divided into two groups: synergic therapy group (ST group, n=20) and monotherapy group (MT group, n=18). All patients were from ICU and defined as severe PJP. In ST group, all patients were treated by SMX-TMP (TMP 15-20 mg/kg per day) combined with caspofungin (70 mg as loading dose then 50 mg/day as maintenance dose) and GCS (methylprednisolone 40-80 mg/day). Patients in MT group were only treated by TMP-SMX (TMP 15-20 mg/kg per day). The clinical response, adverse events and mortality were compared between these two groups.
Results: The positive clinical response in ST group was significant higher than that in MT group, which was 100.00% vs 66.70% (P=0.005). The incidence of adverse events in MT group was higher than that in ST group, which was 50.00% vs 15.00% (P=0.022). Furthermore, the dose of TMP and duration of fever in ST group were remarkably lower than that in MT group, which were 15.71 mg/kg/day vs 18.35 mg/kg/day (P=0.001) and 7.00 days vs 11.50 days (P=0.029), respectively. However, there was no significant differences in all-cause mortality and duration of hospital stay between MT group and ST group.
Conclusions: In comparison with SMZ/TMP monotherapy, the synergic therapy (SMZ-TMP combination of caspofungin and GCS) to treatment non-HIV PJP can increase the positive clinical response rate and decrease the incidence of adverse events and shorten the duration of fever. These results indicated that the synergic therapy was efficacy and safety to treatment severe non-HIV PJP.
Impact of the Home-based Medical Integrated Program on Health Outcomes and Medical Resource Utilization in Taiwan
Authors: Ho Sam Yu-Chieh , Wang Chia-Ti , Weng Tzu-Chieh , Ho Chung-Han , Tsai Kang-Ting , Hsu Chien-Chin , Lin Hung-Jung , Chen Hsiu-Chin , Huang Chien-Cheng 
Published: August 2023

Abstract
Background
The home-based medical integrated program (HMIP) is a novel model for home healthcare (HHC) in Taiwan, initiated in 2016 to enhance care quality. However, the outcomes of this program remain unclear. Thus, we conducted this study to clarify it.
Methods
We utilized the Taiwan National Health Insurance Research Database to identify HHC patients who received HMIP and those who did not between January 2015 and December 2017. A comparison was made between the two groups in terms of outcomes over a one-year follow-up period.
Results
A total of 4,982 HHC patients in the HMIP group and 10,447 patients in the non-HMIP group were identified for this study. The mean age in the HMIP group and non-HMIP group was 77.6 years and 76.1 years, respectively. Compared with the non-HMIP group, the HMIP group had lower total medical costs for HHC, fewer outpatient department visits and lower medical costs, lower medical costs for emergency department visits, fewer hospitalizations, and a lower mortality rate (34.6% vs. 41.2%, p < 0.001).
Conclusion
The HMIP is a promising model for improving care quality and reducing medical resource utilization in HHC patients. While this suggests that the non-HMIP model should be replaced, it’s important to note that both non-HMIP and HMIP models currently coexist. The HMIP may serve as an important reference for other nations seeking to improve care quality and reduce medical resource utilization in their own HHC systems.
Arfid Genes and Environment (ARFID-GEN): Study Protocol
Authors: Bulik Cynthia M. , Micali Nadia , BA Casey M MacDermod , Qi Baiyu , Munn-Chernoff Melissa A , Thornton Laura M , White Jennifer , Dinkler Lisa , Pisetsky Emily M. , Johnson Jessica , Devine Katelin R , Ortiz Shelby N , Silverman Ava E , Berthold Natasha , BA Alexis Dumain , Guintivano Jerry , Halvorsen Matthew , J James 
Published: August 2023

Abstract
Background
The Avoidant Restrictive Food Intake Disorder Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults.
Methods
A total of 3,000 children and adults with ARFID from the United States will be included. Parents/guardians and their children with ARFID (ages 7 to 17) and adults with ARFID (ages 18+) will complete comprehensive online consent, parent verification of child assent (when applicable), and phenotyping. Enrolled participants with ARFID will submit a saliva sample for genotyping. A genome-wide association study of ARFID will be conducted.
Discussion
ARFID-GEN, a large-scale genetic study of ARFID, is designed to rapidly advance the study of the genetics of eating disorders. We will explicate the genetic architecture of ARFID relative to other eating disorders and to other psychiatric, neurodevelopmental, and metabolic disorders and traits. Our goal is for ARFID to deliver “actionable” findings that can be transformed into clinically meaningful insights.
Trial registration:
ARFID-GEN is a registered clinical trial: clinicaltrials.gov NCT05605067
Comprehensive evaluation of medical service ability and resource security level in Tianjin based on factor and cluster analyses
Authors: Lei Xiaoyu , Chu Zhenhai , Liu Dejin , Zhang Wei 
Published: August 2023

Abstract
Background: This study was conducted to evaluate the differences in the medical and health service capacity and resource security levels of various municipal districts in Tianjin and to understand the restrictive factors for the improvement of medical service capacity in each jurisdiction.
Methods: Relevant variables of the 16 municipal districts in Tianjin in 2020 were selected as the research objects, and factor analysis and cluster analysis were used to comprehensively evaluate them.
Results: There were great differences in medical service capacity and resource security levels among the 16 municipal districts, and the development was unbalanced. The medical service capacity and resource security level of each municipal district showed a positive correlation with its economic development level.
Conclusion: The following development suggestions are proposed: speeding up the pace of regional economic development and increasing health support, promoting the government's regulatory and guiding role, rationally allocating medical resources, vigorously supporting the development of medical education and increasing the supply of medical talent.