bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-species comparison of pregnancy-induced GDF15
Authors: Klein Anders Bue , Ranea-Robles Pablo , Nicolaisen Trine Sand , Gil Claudia , Johann Kornelia , Quesada Júlia Prats , Pistolevij Nina , Hviid Kathrine V.R. , Olsen Line F. , Offersen Simone M. , Helge Jørn Wulff , Svarre-Nielsen Henriette , Bakker Jaco , Kleinert Maximillian , Clemmensen Christoffer 
Published: June 2023

AbstractGDF15 (growth differentiation factor 15) is a stress-induced cytokine. Although the exact physiological function of GDF15 is not yet fully comprehended, the significant elevation of circulating GDF15 levels during gestation suggests a potential role for this hormone in pregnancy. This is corroborated by genetic association studies in which GDF15 and the GDF15 receptor, GDNF Family Receptor Alpha Like (GFRAL) have been linked to morning sickness and hyperemesis gravidarum (HG) in humans. Here, we studied GDF15 biology during pregnancy in mice, rats, macaques, and humans. In contrast to macaques and humans, mice and rats exhibited an underwhelming induction in plasma GDF15 levels in response to pregnancy (∼75-fold increase in macaques vs. ∼2-fold increase in rodents). The changes in circulating GDF15 levels were corroborated by the magnitude ofGdf15mRNA and GDF15 protein expression in placentae from mice, rats, and macaques. These species-specific findings may help guide future studies focusing on GDF15 in pregnancy and on the evaluation of pharmacological strategies to interfere with GDF15-GFRAL signaling to treat severe nausea and HG.
Seq-InSite: sequence supersedes structure for protein interaction site prediction
Authors: Hosseini SeyedMohsen , Golding G. Brian , Ilie Lucian 
Published: June 2023

AbstractProteins accomplish cellular functions by interacting with each other, which makes the prediction of interaction sites a fundamental problem. Computational prediction of the interaction sites has been studied extensively, with the structure-based programs being the most accurate, while the sequence-based ones being much more widely applicable, as the sequences available outnumber the structures by two orders of magnitude. We provide here the first solution that achieves both goals. Our new sequence-based program, Seq-InSite, greatly surpasses the performance of sequence-based models, matching the quality of state-of-the-art structure-based predictors, thus effectively superseding the need for models requiring structure. Seq-InSite is illustrated using an analysis of four protein sequences. Seq-InSite is freely available as a web server atseq-insite.csd.uwo.caand as free source code, including trained models and all datasets used for training and testing, atgithub.com/lucian-ilie/seq-insite.
Increased reliance on temporal coding when target sound is softer than the background
Authors: Alamatsaz Nima , Rosen Merri J. , Ihlefeld Antje 
Published: June 2023

AbstractEveryday environments often contain multiple concurrent sound sources that fluctuate over time. Normally hearing listeners can benefit from high signal-to-noise ratios (SNRs) in energetic dips of temporally fluctuating background sound, a phenomenon called dip-listening. Specialized mechanisms of dip-listening exist across the entire auditory pathway. Both the instantaneous fluctuating and the long-term overall SNR shape dip-listening. An unresolved issue regarding cortical mechanisms of dip-listening is how target perception remains invariant to overall SNR, specifically, across different tone levels with an ongoing fluctuating masker. Equivalent target detection over both positive and negative overall SNRs (SNR invariance) is reliably achieved in highly-trained listeners. Dip-listening is correlated with the ability to resolve temporal fine structure, which involves temporally-varying spike patterns. Thus the current work tests the hypothesis that at negative SNRs, neuronal readout mechanisms need to increasingly rely on decoding strategies based on temporal spike patterns, as opposed to spike count. Recordings from chronically implanted electrode arrays in core auditory cortex of trained and awake Mongolian gerbils that are engaged in a tone detection task in 10 Hz amplitude-modulated background sound reveal that rate-based decoding is not SNR-invariant, whereas temporal coding is informative at both negative and positive SNRs.
Gamma-Oscillation Plasticity Is Mediated by Parvalbumin Interneurons
Authors: Hadler Michael D. , Tzilivaki Alexandra , Schmitz Dietmar , Alle Henrik , Geiger Jörg R. P. 
Published: June 2023

AbstractUnderstanding the plasticity of neuronal networks is an emerging field of (patho-)physiological research, yet little is known about the underlying cellular mechanisms. Gamma-oscillations (30 – 80 Hz), a biomarker of cognitive performance, require and potentiate glutamatergic transmission onto parvalbumin-positive interneurons (PVIs), suggesting an interface for cell-to-network plasticity. Inex vivolocal field potential recordings, we demonstrate long-term potentiation of hippocampal gamma-power. Gamma-potentiation obeys established rules of PVI plasticity, requiring calcium-permeable AMPA receptors (CP-AMPARs) and metabotropic glutamate receptors (mGluRs). A microcircuit model of CA3 gamma-oscillations predicts CP-AMPAR plasticity onto PVIs critically outperforms pyramidal cell plasticity in increasing gamma-power and completely accounts for gamma-potentiation. We re-affirm this ex vivo in three PVI-targeting animal models, demonstrating that gamma-potentiation requires PVI-specific metabotropic signaling via a Gq/PKC-pathway comprising mGluR5 and a Gi-sensitive, PKA-dependent pathway. Gamma-activity dependent, metabotropically mediated CP-AMPAR plasticity on PVIs may serve as a guiding principle in understanding network plasticity in health and disease.
Internal audit function, audit report lag and audit fee: evidence from the early stage of COVID-19 pandemic
Authors: Harymawan Iman , Putri Fiona Vista 
Published: June 2023

PurposeHow does the internal audit function make external auditors work more efficiently at the early stage of the COVID-19 pandemic? This study examines the relationship between internal audit function, audit report lag and audit fee at the early stage of the COVID-19 pandemic.Design/methodology/approachThis study uses data from all public firms listed on the Indonesia Stock Exchange from 2018 to 2019 using the difference-in-difference test technique to answer the proposed hypothesis. In addition, this study also tested the issue of endogeneity using Coarsened Exact Matching (CEM) and Two-Stage Least Square (Heckman, 1979).FindingsThis study finds that, at the early stage of the COVID-19 pandemic, a good internal audit function significantly reduced audit report lag and audit fee. These findings indicate that good corporate governance implemented through an internal audit function during the COVID-19 pandemic can give assurance to prevent and mitigate the firm's risk so that external auditors can work more efficiently. Furthermore, this study also carries out an additional analysis by subsampling the high and low technological industries. Based on the robustness test, it is revealed that the results of this study are consistent.Originality/valueThis study contributes to the novelty of literature in auditing studies that highlights the audit process at the early stage of the COVID-19 pandemic
Uncertain futures: perceptions of refugees in a story completion task
Authors: Parker Samuel , Earnshaw Deborah , Penn Emma , Kumari Roshni 
Published: June 2023

PurposeIn recent years the movement of refugees has led to increasing negative media and political discourse about migration in the United Kingdom, particularly as the number of refugees crossing the English Channel has increased. Despite this hostility, little is known about how the UK public perceive the journeys made by refugees or the refugees themselves.Design/methodology/approachIn this study the authors used a story completion method to analyse perceptions and understandings of refugees. Participants were given the opening of a story about refugees crossing the English Channel and were asked to complete the remainder of the story. In total, 84 participants completed stories that ranged in length from two to 423 words. The stories were analysed using reflexive thematic analysis.FindingsEach of the completed stories was analysed using reflexive thematic analysis and three themes were generated: Conflicting emotions: Uncertainty and the relief of reaching safety after a traumatic journey; The spectre of illegality: Borders and the uncertainty of what happens next; and Welcome or unwelcome?: Cultural values of welcome and hospitality.Originality/valueThe authors argue that this original use of the story completion method highlights how participants draw on cultural narratives of hospitality and welcome and that their stories are constructed using emotional categories that are in contrast to the more binary constructions of refugees that are present in media and government discourse about refugees and the English Channel crossings.
Evaluating the use of the ABCD2 score as a clinical decision aid in the emergency department: Retrospective observational study
Authors: Wahi Siddhant , Michaleff Zoe A , Lomax Paige , Brand Adam , van der Merwe Madeleen , Jones Mark , Glasziou Paul , Keijzers Gerben 
Published: June 2023

AbstractObjectiveClinical decision aids (CDAs) can help clinicians with patient risk assessment. However, there is little data on CDA calculation, interpretation and documentation in real‐world ED settings. The ABCD2 score (range 0–7) is a CDA used for patients with transient ischaemic attack (TIA) and assesses risk of stroke, with a score of 0–3 being low risk. The aim of this study was to describe ABCD2 score documentation in patients with an ED diagnosis of TIA.MethodsRetrospective observational study of patients with a working diagnosis of a TIA in two Australian EDs. Data were gathered using routinely collected data from health informatics sources and medical records reviewed by a trained data abstractor. ABCD2 scores were calculated and compared with what was documented by the treating clinician. Data were presented using descriptive analysis and scatter plots.ResultsAmong the 367 patients with an ED diagnosis of TIA, clinicians documented an ABCD2 score in 45% (95% CI 40–50%, n = 165). Overall, there was very good agreement between calculated and documented scores (Cohen's kappa 0.90). The mean documented and calculated ABCD2 score were similar (3.8, SD = 1.5, n = 165 vs 3.7, SD = 1.8, n = 367). Documented scores on the threshold of low and high risk were more likely to be discordant with calculated scores.ConclusionsThe ABCD2 score was documented in less than half of eligible patients. When documented, clinicians were generally accurate with their calculation and application of the ABCD2. No independent predictors of ABCD2 documentation were identified.
Patterns of practice regarding use of radiation therapy following radical prostatectomy: A survey of Radiation Oncologists and Urologists in Australia and New Zealand
Authors: Lawless Anna , Kneebone Andrew , Armstrong Shreya , Chander Sarat , Christie David , Finnigan Renee , Hayden Amy , Higgs Braden , Knox Matthew , Sasso Giuseppe , Sidhom Mark , Shakespeare Thomas P , Holt Tanya 
Published: June 2023

AbstractIntroductionThis study aimed to investigate the patterns of practices of radiation oncologists (ROs) and urologists in Australia and New Zealand with respect to the utilisation of post‐prostatectomy radiation therapy (RT) and help guide the development of an update to the existing Faculty of Radiation Oncology Genito‐Urinary Group post‐prostatectomy guidelines.MethodsROs and urologists with subspecialty practice in prostate cancer from Australia and New Zealand were invited to participate in an online survey comprised of clinical scenarios regarding post‐prostatectomy RT.ResultsSixty‐five ROs and 28 urologists responded to the survey. In the setting of low‐risk biochemical relapse, the threshold for initiating RT was lower for ROs than urologists. ROs were more likely than urologists to recommend adjuvant RT for node‐positive disease. When salvage RT was advised for a pT3N0R1 recurrence, there was no consensus amongst ROs on whether to add either ADT or nodal treatment over prostate bed RT alone. For a solitary PSMA‐avid pelvic lymph node recurrence, whole pelvis RT with androgen deprivation therapy was the preferred treatment option (72% ROs, 43% urologists). Most ROs (92%) recommended conventionally fractionated RT to 66–70 Gy, with a boost to any PSMA PET avid recurrent disease.ConclusionThis survey highlights the marked discordance in practice for the management of prostate cancer relapse post‐prostatectomy. This is seen not only between specialties but also within the radiation oncology community. This emphasises the need for an updated evidence‐based guideline to be produced.
Is HbA1c associated with birth weight? A multivariable analysis of Pakistani pregnant women
Authors: Silke Olivia , Yim Ilona S. , Shaikh Kiran , Lalani Sharifa , Ghani Farooq , Wanyonyi Sikolia , Samia Pauline , Merali Mohamoud , Omuse Geoffrey , Okoko Christine , Forcheh Ntonghanwah , Premji Shahirose S. ,   the Maternal‐infant Global Health Team (MiGHT) Collaborators in Research
Published: June 2023

AbstractAimGlobally, one in seven infants is born with low birth weight and 3%–7% of infants are born with high birth weight, with the greatest burden noted in low‐ and middle‐income countries. This study investigated the association between maternal prenatal glucose regulation and birth weight and the moderating effect of fetal sex among Pakistani women.MethodsSecondary data from a prospective longitudinal study of healthy pregnant women from Pakistan (N = 189) was used. Participants provided a blood sample (12–19 weeks' gestational age) for the assessment of HbA1c (%). Birth weight (g) was collected following delivery.ResultsHigher maternal HbA1c was associated with higher birth weight (b = 181.81, t[189] = 2.15, p = 0.03), which was moderated by fetal sex (b = −326.27, t[189] = −2.47, p = 0.02), after adjusting for gestational age at birth, ethnicity, and pregnancy weight. Among women carrying a male fetus, every 1% increase in HbA1c predicted a 182 g increase in birth weight (b = 181.81, t[189] = 2.15, p = 0.03).ConclusionsResults extend research from high‐income countries and indicate that fetal sex may have implications for glucose regulation in early to mid‐pregnancy. Future research should examine sociocultural factors, which could elucidate potential mediating factors in the relation between HbA1c and birth weight in healthy pregnancies.
Spatial configuration of hundreds charts influences children's knowledge of base‐ten concepts
Authors: Osana Helena P. , Wagner Vera , Navarrete‐Ulloa Jairo A. 
Published: June 2023

AbstractThe hundreds chart is a valuable tool for teachers in elementary mathematics classrooms. The present study investigated the effects of spatial configurations of virtual hundreds charts on children's knowledge of base‐ten concepts. Kindergarten and first‐grade students were assigned to three instructional conditions in which they worked with a researcher to solve arithmetic word problems. The charts used in the conditions differed by the spatial configuration of the numbers: (a) top down, with numbers increasing from top to bottom; (b) bottom up, with increases from bottom to top; and (c) explicit bottom‐up, with a bottom‐up chart and an explicit visual cue that prompted a comparison between the “up‐is‐more” structure to a cylinder filling with water. Participants were more likely to count by tens than by ones to solve problems when the numbers in the chart increased from top to bottom than when they increased from bottom to top. No effects of spatial configuration on place‐value knowledge was observed. One account of the findings is that participants were more accustomed to the movements in the top‐down chart because they matched the direction in which children learn to read. The role of spatial affordances of instructional materials in children's mathematics learning is discussed.
Comparison of Deformation Patterns Excited in the Human Brain In Vivo by Harmonic and Impulsive Skull Motion
Authors: Escarcega Jordan D. , Knutsen Andrew K. , Alshareef Ahmed A. , Johnson Curtis L. , Okamoto Ruth J. , Pham Dzung L. , Bayly Philip V. 
Published: June 2023

Abstract
Noninvasive measurements of brain deformation in human participants in vivo are needed to develop models of brain biomechanics and understand traumatic brain injury (TBI). Tagged magnetic resonance imaging (tagged MRI) and magnetic resonance elastography (MRE) are two techniques to study human brain deformation; these techniques differ in the type of motion and difficulty of implementation. In this study, oscillatory strain fields in the human brain caused by impulsive head acceleration and measured by tagged MRI were compared quantitatively to strain fields measured by MRE during harmonic head motion at 10 and 50 Hz. Strain fields were compared by registering to a common anatomical template, then computing correlations between the registered strain fields. Correlations were computed between tagged MRI strain fields in six participants and MRE strain fields at 10 Hz and 50 Hz in six different participants. Correlations among strain fields within the same experiment type were compared statistically to correlations from different experiment types. Strain fields from harmonic head motion at 10 Hz imaged by MRE were qualitatively and quantitatively similar to modes excited by impulsive head motion, imaged by tagged MRI. Notably, correlations between strain fields from 10 Hz MRE and tagged MRI did not differ significantly from correlations between strain fields from tagged MRI. These results suggest that low-frequency modes of oscillation dominate the response of the brain during impact. Thus, low-frequency MRE, which is simpler and more widely available than tagged MRI, can be used to illuminate the brain's response to head impact.
In Search of a Universal Rough Wall Model
Authors: Yang Xiang I. A. , Zhang Wen , Yuan Junlin , Kunz Robert F. 
Published: June 2023

Abstract
This work compares various existing rough-wall models on a large collection of rough surfaces with different characteristics and studies the potential of these models in accommodating new datasets. We consider three empirical roughness correlations, two physics-based models, and one data-driven machine-learning model on 68 rough surfaces inside and outside the Roughness Database1. Results show that correlation-type models and machine-learning models do not extrapolate outside the dataset against which they are calibrated or trained. In contrast, the physics-based sheltering model performs well in extrapolation. Recalibrating a roughness correlation against a large dataset proves unfruitful. However, retraining a machine learning model yields good results. We do not pursue further retraining and recalibrating of a physics-based model, as it requires new physical insights. Overall, our findings suggest that a universal rough-wall model is yet to be found. The capability of extrapolation will likely come from incorporating physics. Data, on the other hand, benefits machine learning models.
Interfacial Fracture Caused by Electromigration at Copper Interconnects
Authors: Wang Yuexing , Li Bofeng , Zhifeng Yao , Yao Yao 
Published: June 2023

Abstract
The present investigation delves into the failure model of cracking at the Cu/dielectric interface, specifically at the anode end of a copper interconnect that is triggered by electromigration. The study employs the continuous dislocation model to determine the stress field caused by interfacial mass diffusion that exists within and outside of the copper line. Apart from the anticipated tensile or compressive stress on the cathode or anode side, an anomalous stress singularity is identified at the interface between the dielectric layer and the anode end of the copper line. This singular stress distribution leads to cracking in the compressive portion of the dielectric layer at the anode end under the influence of electromigration. The theoretical predictions are in good agreement with experimental data, and a novel failure criterion akin to the stress intensity factor in fracture mechanics is formulated.
Quantitative measurement of the requirement of diverse protein degradation pathways in MHC class I peptide presentation
Authors: Mamrosh Jennifer L. , Sherman David J. , Cohen Joseph R. , Johnston James A. , Joubert Marisa K. , Li Jing , Lipford J. Russell , Lomenick Brett , Moradian Annie , Prabhu Siddharth , Sweredoski Michael J. , Vander Lugt Bryan , Verma Rati , Deshaies Raymond J. 
Published: June 2023

Peptides from degradation of intracellular proteins are continuously displayed by major histocompatibility complex (MHC) class I. To better understand origins of these peptides, we performed a comprehensive census of the class I peptide repertoire in the presence and absence of ubiquitin-proteasome system (UPS) activity upon developing optimized methodology to enrich for and quantify these peptides. Whereas most class I peptides are dependent on the UPS for their generation, a surprising 30%, enriched in peptides of mitochondrial origin, appears independent of the UPS. A further ~10% of peptides were found to be dependent on the proteasome but independent of ubiquitination for their generation. Notably, clinically achievable partial inhibition of the proteasome resulted in display of atypical peptides. Our results suggest that generation of MHC class I•peptide complexes is more complex than previously recognized, with UPS-dependent and UPS-independent components; paradoxically, alternative protein degradation pathways also generate class I peptides when canonical pathways are impaired.