bluuebunny/crossref_metadata_2025_split huggingface dataset:
Living donor-gifted allograft lithiasis: surgical experience after bench surgery stone removal and follow-up
Authors: Sierra Alba , Castillo Carlos , Carbonell Enric , Muní Maria , Martinez Carmen , López Juan Manuel , Peri Lluís , Alcaraz Antonio , Luque Maria Pilar , Musquera Mireia 
Published: June 2023

AbstractThis study presents the surgical experience and long-term outcomes of living donor kidney transplantations involving asymptomatic kidney stones, using ex vivo flexible ureterorenoscopy (f-URS) during bench surgery for stone removal. Out of 1743 living kidney donors assessed between January 2012 and October 2022, 18 (1%) were diagnosed with urolithiasis. Among them, 12 donors were rejected, and 6 were accepted for kidney donation. Stone removal was successfully performed using f-URS during bench surgery, with no immediate complications or acute rejections observed. The study analyzed six living kidney transplants, of which 4 (67%) donors and three recipients were female, and 4 (67%) donors were blood-related to the recipient. The median age for donors and recipients was 57.5 and 51.5 years, respectively. The stones, primarily located in the lower calyx, had a median size of 6 mm. The median cold ischemia time during surgery was 41.6 min, and ex vivo f-URS ensured complete stone removal in all cases. After a median follow-up of 120 months, the remaining grafts were functioning well, and no urinary stone recurrence was observed in either the recipients or living donors. The findings suggest that bench f-URS is a safe approach for managing urinary stones in kidney grafts, providing good functional outcomes without stone recurrence in selected cases.
Prognostic value of imaging-based ATN profiles in a memory clinic cohort
Authors: Peretti Débora E. , Ribaldi Federica , Scheffler Max , Chicherio Christian , Frisoni Giovanni B. , Garibotto Valentina 
Published: June 2023

Abstract
Purpose
The ATN model represents a research framework used to classify subjects based on the presence or absence of Alzheimer’s disease (AD) pathology through biomarkers for amyloid (A), tau (T), and neurodegeneration (N). The aim of this study was to assess the relationship between ATN profiles defined through imaging and cognitive decline in a memory clinic cohort.

Methods
One hundred-eight patients from the memory clinic of Geneva University Hospitals underwent complete clinical and neuropsychological evaluation at baseline and 23 ± 5 months after inclusion, magnetic resonance imaging, amyloid and tau PET scans. ATN profiles were divided into four groups: normal, AD pathological change (AD-PC: A + T-N-, A + T-N +), AD pathology (AD-P: A + T + N-, A + T + N +), and suspected non-AD pathology (SNAP: A-T + N-, A-T-N + , A-T + N +).

Results
Mini-Mental State Examination (MMSE) scores were significantly different among groups, both at baseline and follow-up, with the normal group having higher average MMSE scores than the other groups. MMSE scores changed significantly after 2 years only in AD-PC and AD-P groups. AD-P profile classification also had the largest number of decliners at follow-up (55%) and the steepest global cognitive decline compared to the normal group. Cox regression showed that participants within the AD-P group had a higher risk of cognitive decline (HR = 6.15, CI = 2.59–14.59), followed by AD-PC (HR = 3.16, CI = 1.17–8.52).

Conclusion
Of the different group classifications, AD-P was found to have the most significant effect on cognitive decline over a period of 2 years, highlighting the value of both amyloid and tau PET molecular imaging as prognostic imaging biomarkers in clinical practice.
Predicting response to chemoradiotherapy in rectal cancer via visual morphologic assessment and staging on baseline MRI: a multicenter and multireader study
Authors: El Khababi Najim , Beets-Tan Regina G. H. , Tissier Renaud , Lahaye Max J. , Maas Monique , Curvo-Semedo Luís , Dresen Raphaëla C. , Nougaret Stephanie , Beets Geerard L. , Lambregts Doenja M. J. ,   on behalf of the rectal MRI study group, Bakers Frans C. H. , Barros Perla , Bauer Ferdinand , de Bie Shira H , Ballantyne Stuart , Dutra Joanna Brayner , Buskov Laura , Bogveradze Nino , Bosma Gerlof P. T. , Cappendijk Vincent C , Castagnoli Francesca , Charalampos Sotiriadis , Delli Pizzi Andrea , Digby Michael , Geenen Remy W. F. , van Griethuysen Joost J. M. , Lafrance Julie , Mahajan Vandana , Malekzadeh Sonaz , Neijenhuis Peter A , Peterson Gerald M , Pieters Indra , Schurink Niels W. , Smit Ruth , Veeken Cornelis J. , Vliegen Roy F. A. , Wray Andrew , Zeina Abdel-Rauf 
Published: June 2023

Abstract
Purpose
Pre-treatment knowledge of the anticipated response of rectal tumors to neoadjuvant chemoradiotherapy (CRT) could help to further optimize the treatment. Van Griethuysen et al. proposed a visual 5-point confidence score to predict the likelihood of response on baseline MRI. Aim was to evaluate this score in a multicenter and multireader study setting and compare it to two simplified (4-point and 2-point) adaptations in terms of diagnostic performance, interobserver agreement (IOA), and reader preference.

Methods
Twenty-two radiologists from 14 countries (5 MRI-experts,17 general/abdominal radiologists) retrospectively reviewed 90 baseline MRIs to estimate if patients would likely achieve a (near-)complete response (nCR); first using the 5-point score by van Griethuysen (1=highly unlikely to 5=highly likely to achieve nCR), second using a 4-point adaptation (with 1-point each for high-risk T-stage, obvious mesorectal fascia invasion, nodal involvement, and extramural vascular invasion), and third using a 2-point score (unlikely/likely to achieve nCR). Diagnostic performance was calculated using ROC curves and IOA using Krippendorf’s alpha (α).

Results
Areas under the ROC curve to predict the likelihood of a nCR were similar for the three methods (0.71–0.74). IOA was higher for the 5- and 4-point scores (α=0.55 and 0.57 versus 0.46 for the 2-point score) with best results for the MRI-experts (α=0.64-0.65). Most readers (55%) favored the 4-point score.

Conclusions
Visual morphologic assessment and staging methods can predict neoadjuvant treatment response with moderate–good performance. Compared to a previously published confidence-based scoring system, study readers preferred a simplified 4-point risk score based on high-risk T-stage, MRF involvement, nodal involvement, and EMVI.

Graphical abstract
Combined volume and surface rendering with global illumination caching
Authors: Šmajdek Uroš , Lesar Žiga , Marolt Matija , Bohak Ciril 
Published: June 2023

AbstractWe present a combined volume and surface rendering technique with global illumination caching. Our approach uses volumetric path tracing to compute the global illumination volume and local shading models for rendering the isosurface. By joining both visualization approaches, we have enhanced the display and illumination of the surfaces while preserving physically realistic illumination of the participating media. To achieve real-time performance and avoid recomputing the image when the camera view changes, we compute the global illumination volume incrementally and defer the projection to a later step. We evaluated our technique by comparing different local shading models for isosurface rendering with the result of full volumetric path tracing and with the non-caching variant of our technique. Results show that the caching and non-caching variants perform comparably well, while the caching variant has the added benefit of being camera-view-independent. Additionally, we show that our approach emphasizes the surfaces within volumes better than volumetric path tracing.
Geriatrisches Assessment in der Zahnmedizin
Authors: Schlenz Maximiliane Amelie , Schmidt Alexander , Gäbler Clara Sophie , Kolb Gerald , Wöstmann Bernd 
Published: June 2023

ZusammenfassungDurch die steigende Lebenserwartung und den damit verbundenen demografischen Wandel sind immer mehr Menschen auf Pflege angewiesen. Um erste Hinweise auf einen möglichen notwendigen zahnärztlichen Behandlungsbedarf zu geben, haben sich im zahnmedizinischen Bereich Kaufunktionstests als Assessmentinstrumente bewährt. Im vorliegenden Beitrag wird dem Leser eine Übersicht über vorhandene Kaufunktionstests und deren Durchführung gegeben. An dieser Stelle ist darauf hinzuweisen, dass ein Patient mit Schmerzen unabhängig von einem Kaufunktionstest unverzüglich einer Zahnärztin/einem Zahnarzt vorgestellt werden sollte. Weiterhin ersetzen Kaufunktionstests keine zahnärztlichen Routineuntersuchungen, könnten jedoch auch (zahn-)medizinischen Laien Hinweise darauf geben, ob ein Termin in einer Zahnarztpraxis vereinbart werden sollte oder ein zahnärztliches Konsil notwendig ist.
Evaluation of outcome of acoustic reflex tests in patients with type 2 diabetes mellitus: a cross-sectional study
Authors: Praneetha Puvvula , Dosemane Deviprasad , Khadilkar Meera Niranjan , Kumar Kaushlendra , Ebenezer Anupriya 
Published: June 2023

Abstract
Purpose
Type 2 diabetes mellitus (T2DM) may induce micro-vascular and macro-vascular changes that can lead to neuropathic changes which may affect the auditory pathway resulting in hearing loss. The study aims to evaluate the outcome of ipsilateral and contralateral acoustic reflex (AR) parameters and reflex decay tests (RDT) in patients with T2DM, and the relationship between average AR parameters, and duration and control of T2DM.

Methods
An analytical cross-sectional study was conducted in a tertiary care setup in 126 subjects which included 42 subjects with T2DM between 30 and 60 years of age, age-matched with 84 non-diabetic subjects. The subjects were evaluated for pure tone average (PTA), speech identification score (SIS), AR parameters [acoustic reflex threshold (ART), acoustic reflex amplitude (ARA), acoustic reflex latency (ARL)] and RDT.

Results
The subjects with T2DM showed increased PTA in both ears when compared to the subjects with no disease. No significant difference was found in the SIS between both groups. There was no significant difference in the ART and ARL between the two groups. There was a significant difference in the ipsilateral and contralateral ARA at 500 Hz, 1000 Hz and broadband noise (BBN) when compared between the diabetic and non-diabetic groups. No significant difference was found between average AR parameters and duration and control of T2DM.

Conclusion
T2DM increases hearing thresholds and reduces ipsilateral and contralateral AR at lower frequencies and BBN. Duration and control of T2DM do not affect the AR parameters.
Quartz-in-garnet (QuiG) under pressure: insights from in situ Raman spectroscopy
Authors: Campomenosi Nicola , Angel Ross J. , Alvaro Matteo , Mihailova Boriana 
Published: June 2023

AbstractElastic geothermobarometry relies on the contrast between the thermal expansion and compressibility of a mineral inclusion and its surrounding host, leading to a residual pressure in the inclusion (Pinc) that may differ significantly from the external pressure. Quartz-in-garnet (QuiG) inclusion-host systems are widely used in elastic geothermobarometry to estimate the inclusion entrapment conditions and thus the rock petrogenesis. To elucidate the behaviour of QuiG at elevated pressures, we have applied in situ high-pressure Raman spectroscopy on three QuiG samples having Pinc close to 0 GPa at room temperature. We demonstrate that upon pressure increase, the garnet host acts as a shield to the softer quartz inclusion. Consequently, the Pinc increases with a smaller rate compared to that of the external pressure. Up to 2.5 GPa, the evolution of Pinc calculated from the Raman data agrees very well with prediction from the equations of state. Furthermore, the behaviour of a quartz inclusion in a relatively thin host specimen was explored up to external pressures of 7 GPa. Our results indicate that the shielding effect of the host (even if only partial because of the insufficient distance between the inclusion and the host surface) can keep the quartz inclusions thermodynamically stable up to about 2 GPa above the equilibrium quartz–coesite phase boundary. In addition, the partial shielding leads to the development of anisotropic symmetry-breaking stresses and quartz inclusions undergo a reversible crossover to a lower symmetry state. Given that the presence of non-hydrostatic stress may influence the quartz-to-coesite phase boundary, especially at elevated temperatures relevant for entrapment conditions, our results emphasize the importance of elastic anisotropy of QuiG systems, especially when quartz inclusion entrapment occurs under conditions close to the coesite stability field.
Autonomic dysfunction is associated with disease progression and survival in amyotrophic lateral sclerosis: a prospective longitudinal cohort study
Authors: Dubbioso Raffaele , Provitera Vincenzo , Pacella Daniela , Santoro Lucio , Manganelli Fiore , Nolano Maria 
Published: June 2023

Abstract
Background
Among non-motor symptoms, autonomic disturbances have been described in amyotrophic lateral sclerosis (ALS) and reported as mild to moderate in up to 75% of patients. However, no study has systematically investigated autonomic symptoms as prognostic factors.

Objectives
The main aim of this longitudinal study was to examine the association of autonomic dysfunction with disease progression and survival in ALS.

Methods
We enrolled newly diagnosed ALS patients and a healthy control group (HC). Time from disease onset to disease milestone (King’s stage 4) and death were calculated to assess disease progression and survival. Autonomic symptoms were assessed by a dedicated questionnaire. Longitudinal evaluation of parasympathetic cardiovascular activity was performed by the heart rate variability (HRV). Multivariable Cox proportional hazards regression models on the risk of the disease milestone and death were used. A mixed-effect linear regression model was used to compare autonomic dysfunction with a HC group as well as its impairment over time.

Results
A total of 102 patients and 41 HC were studied. ALS patients, compared with HC, complained of more autonomic symptoms, especially in bulbar onset patients. Autonomic symptoms occurred in 69 (68%) patients at diagnosis and progressed over time (post-6: p = 0.015 and post-12: p < 0.001). A higher autonomic symptom burden was an independent marker of faster development of King’s stage 4 (HR 1.05; 95% CI 1.00–1.11; p = 0.022); whereas, urinary complaints were independent factors of a shorter survival (HR 3.12; 95% CI 1.22–7.97; p = 0.018). Moreover, HRV in ALS patients was lower than in HC (p = 0.018) and further decreased over time (p = 0.003), implying a parasympathetic hypofunction that progressed over time.

Conclusion
Autonomic symptoms occur in most of the ALS patients at diagnosis and progress over time, implying that autonomic dysfunction represents an intrinsic non-motor feature of the disease. A higher autonomic burden is a poor prognostic factor, associated with a more rapid development of disease milestones and shorter survival.
Regulating cancer risk prediction: legal considerations and stakeholder perspectives on the Canadian context
Authors: Moreno Palmira Granados , Knoppers Terese , Zawati Ma’n H. , Lang Michael , Knoppers Bartha M. , Wolfson Michael , Nabi Hermann , Dorval Michel , Simard Jacques , Joly Yann 
Published: June 2023

AbstractRisk prediction models hold great promise to reduce the impact of cancer in society through advanced warning of risk and improved preventative modalities. These models are evolving and becoming more complex, increasingly integrating genetic screening data and polygenic risk scores as well as calculating risk for multiple types of a disease. However, unclear regulatory compliance requirements applicable to these models raise significant legal uncertainty and new questions about the regulation of medical devices. This paper aims to address these novel regulatory questions by presenting an initial assessment of the legal status likely applicable to risk prediction models in Canada, using the CanRisk tool for breast and ovarian cancer as an exemplar. Legal analysis is supplemented with qualitative perspectives from expert stakeholders regarding the accessibility and compliance challenges of the Canadian regulatory framework. While the paper focuses on the Canadian context, it also refers to European and U.S. regulations in this domain to contrast them. Legal analysis and stakeholder perspectives highlight the need to clarify and update the Canadian regulatory framework for Software as a Medical Device as it applies to risk prediction models. Findings demonstrate how normative guidance perceived as convoluted, contradictory or overly burdensome can discourage innovation, compliance, and ultimately, implementation. This contribution aims to initiate discussion about a more optimal legal framework for risk prediction models as they continue to evolve and are increasingly integrated into landscape for public health.
Components of high-resolution manometry that change surgical decisions
Authors: Wiese Georg , Delgado Carlos , Inayat Irteza , Eubanks Steve 
Published: June 2023

Abstract
Background
High-resolution manometry (HRM) is vital in evaluating patients for surgery at the gastroesophageal (GE) junction. Previously, we reported manometry alters surgery choices at the GE junction over 50% of the time, and its components, i.e., abnormal motility and distal contractile integral (DCI), are vital in decision-making. This single-institution retrospective study examines how HRM characteristics, reported with the Chicago classification, can alter the intended surgical plans for foregut surgery.

Methods
We collected data on pre-operative symptoms for patients undergoing HRM studies from 2012 to 2016, i.e., Upper GI X-rays, 48-h pH studies, DeMeester scores, upper endoscopy, and biopsy reports. HRM results were further categorized via Chicago classification (i.e., normal or abnormal motility). The DCI was determined; Patients not seen by a surgeon were excluded. Then a single surgeon, blinded to patient identity and HRM results, determined the planned procedure. The reviewer was then exposed to the HRM results; procedural plans were revised if needed. HRM results were then evaluated to determine which factors most influenced the surgical decisions.

Results
298 HRM studies were initially identified; 114 met search criteria. Overall, HRM altered the planned procedure in 50.9% of cases (n = 58), with abnormal motility in 54.4% (62/114) cases. Abnormal motility findings corresponded to 70.6% (41/58) of the patients in which HRM changed the surgery decision. A DCI of < 1000 was identified in only 31.6% (36/114) of all patients, but 39.7% (23/58) of cases where the surgical decision was altered. A DCI of > 5000 was identified in only 10.5% (12/114) of all patients but 10.3% (6/58) of cases with altered surgical decisions. A DCI < 1000 and abnormal motility were generally associated with a partial fundoplication.

Conclusions
This study demonstrates the impact of identifying abnormal motility via the Chicago classification and factors like DCI on surgical choice at the GE junction.
Longitudinal evolution of meaning in life and its relationship with coping strategies in Spanish patients with a breast cancer diagnosis
Authors: Marco Jose H. , Castejón Jessica , Isern Carmen , Grau Lola , Pérez Rodríguez Sandra 
Published: June 2023

Abstract
Background
Changes in Meaning in life (MIL) have been shown to be particularly important when people face very stressful events such as receiving a cancer diagnosis and treatment. Active coping strategies have been related to higher levels of MIL in people with a diagnosis of cancer.

Objective
To explore the evolution of MIL in a sample of cancer patients at the time of their diagnosis and three, six, and nine months after surgery, and identify the association between coping strategies three months after diagnosis (T2) and levels of MIL at the different moments in the cancer process (T1-T4).

Methods
We assessed MIL at diagnosis and three, six, and nine months after surgery, and coping strategies (fighting spirit, anxious preoccupation, hopelessness, fatalism, and cognitive avoidance) three months after surgery, in 115 women with a diagnosis of Stage I-III breast cancer.

Results
We found higher levels of MIL nine months after surgery, compared to previous stages. MIL correlated significantly and positively with a fighting spirit and cognitive avoidance, and negatively with hopelessness and anxious preoccupation.

Conclusions
Results highlight the importance of coping in relation to meaning-making processes in cancer. Meaning-centred interventions could help patients who are in the process of coping with cancer to make sense of their lives and the experience.
Dimensional and positional temporomandibular joint osseous characteristics in normodivergent facial patterns with and without temporomandibular disorders
Authors: Alhammadi Maged S. , Almashraqi Abeer A. , Thawaba Ahmed A. , Fayed Mona M. Salah , Aboalnaga Amira A. 
Published: June 2023

Abstract

Objective
This study evaluated the dimensional and positional osseous temporomandibular joint features in normodivergent facial patterns with and without temporomandibular disorders.

Methods
A total of 165 adult patients were divided into two groups: group 1 (n = 79 patients; 158 joints): temporomandibular disorders patients and group 2 (n = 86 patients; 172 joints): non-temporomandibular disorders patients. Three-dimensional positional and dimensional temporomandibular joint characteristics, including glenoid fossa, mandibular condyles, and joint spaces, were assessed by cone beam computed tomography.

Results
The glenoid fossa positions in the three orthogonal planes and height showed statistical significance between the two studied groups. The temporomandibular disorders patients showed higher horizontal and vertical condyle inclinations while anteroposterior inclination was less, and the condyle was positioned more superior, anterior, and lateral in the glenoid fossa. The condyle width and length showed no significance between the two groups, while condyle height was smaller in temporomandibular disorders patients. Anterior and medial joint spaces increased while the superior and posterior joint spaces reduced in temporomandibular disorders patients.

Conclusion
There were significant differences between the patients with and without temporomandibular joint disorders in terms of mandibular fossa positions and height as well as condylar positions and inclinations in horizontal and vertical planes together with reduced condylar height and reduced posterior and superior joint spaces in the temporomandibular disorders patients.

Clinical relevance
The temporomandibular disorder is a multifactorial disorder in which one of these factors is the dimensional and positional characteristics of the temporomandibular joints; including or excluding this factor requires a comprehensive three-dimensional investigation of patients with TMD compared to the normal group under the condition that the facial pattern is average as a confounding factor.