bluuebunny/crossref_metadata_2025_split huggingface dataset:
TATA KELOLA PEMERINTAHAN YANG BAIK TENTANG PARTISIPASI MASYARAKAT DALAM PEMBUATAN PERATURAN DESA DI DESA SUNGAI PINANG KECAMATAN RAMBUTAN BANYUASIN
Authors: Dedeng Dedeng , Nugraha Adrian , Pasyah Taroman , Syaifuddin Muhammad , Idris Akhmad , Saputra Ricky , Yunithia Putri Taufani 
Published: August 2023

Partisipasi masyarakat dalam pembuatan Peraturan Desa (Perdes) termasuk pada aspek pembangunan di Desa tidak hanya dipandang sebagai bagian dari proses tetapi juga merupakan bagian dari tujuan, dimana partisipasi merupakan salah satu indikator tingkat keberhasilan khususnya program pembangunan desa. Misal, partisipasi masyarakat dalam bentuk Pembentukan Peraturan Desa (Perdes) yang partisipatif harus mencerminkan komitmen bersama antara Kepala Desa (Kades), Badan Permusyawaratan Desa (BPD) dan masyarakat Desa, hal tersebut dilakukan guna membuat suatu Peraturan Desa yang benar-benar sesuai dengan kebutuhan masyarakat Desa tersebut. Partisipasi masyarakat dalam pembentukan Peraturan Desa merupakan wujud dari penyelenggaraan pemerintahan yang baik sesuai dengan prinsip-prinsip good governance, diantaranya meliputi keterlibatan masyarakat, akuntabilitas, dan transparansi. Sehingga kegiatan ini sangat penting dilakukan dalam bentuk perkuliahan Desa yaitu bagi masyarakat, Perangkat Desa dan Badan Perwakilan Desa (BPD). Dengan perkuliahan Desa ini diharapkan meningkatnya person masyarakat untuk kontribusi pada pembentukan peraturan di Desa sebagai sarana perwujudan Undang-Undang Desa dan Tata Kelola Pemerintahan Desa Yang Baik atau dikenal pula dengan istilah Good Governance. Adapun metode perkuliahan Desa yang digunakan adalah dalam bentuk pemberian materi perkuliahan yaitu Tata Kelola Pemerintahan, Asas-Asas Hukum Tata Kelola Pemrintahan, Pemerintahan Desa, Pengaturan tentang Desa, Pembuatan kebijakan, partisipasi masyarakat, gambaran dan mekanisme pembuatan peraturan, kriteria dan aturan tentang pembuatan perundang-undangan serta materi lain yang terkait dalam ruang lingkup partisipasi masyarakat dan pembuatan Peraturan Desa itu sendiri.
Kata Kunci: Peraturan Desa, Partisipasi Masyarakat dan Desa
O ensino do piano e o transtorno do espectro do autismo: uma revisão sistemática
Authors: Neves Maria Teresa de Souza , Fonseca Maria Betânia Parizzi , Nunes Natália , Freire Marina 
Published: August 2023

Buscando compreender as relações entre o Piano e Transtorno do Espectro do Autismo (TEA) de modo a favorecer as ações dos educadores musicais/professores de piano e contribuir com a produção acadêmica da área de pedagogia do piano, esse trabalho tem como objetivo investigar, por meio de uma revisão sistemática, o conhecimento produzido sobre o ensino de piano para pessoas autistas, até o presente momento. A busca dos trabalhos foi realizada nas seguintes bases de dados: Periódicos da CAPES, Banco de Teses Brasileiras (BDTD), Portal Brasileiro de Acesso Aberto à Informação Científica (OasisBr), ResearchGate e Scopus, e nos principais periódicos nacionais da área de música. Foram eleitos 15 trabalhos, e a literatura revisada aponta a importância de que o professor conheça estratégias de ensino diversificadas e saiba adequá-las às limitações e potencialidades do aluno, buscando sempre proporcionar vivências musicais significativas no aprendizado do instrumento.
Speak-to-Write from Multiple Perspectives, as Method
Authors: Eidsheim Nina Sun , Bellocq Juliette 
Published: August 2023

One of the practice-based research methods that excites me the most today is to work with writing as a practice, and as a practice-based research method. The technology of writing can be very misleading, especially when that writing is typed using a word processing program. When using this tool, writing looks the same whether it represents a stream of consciousness, a first draft, or a final proof. Because of this, I have found that I hold myself to the standard of the final version, which of course completely freezes me up. If we are always aiming for the final version, there is not much room for thinking, making errors, going sideways and backward and forward again. There is only the guaranteed feeling of failure.
In response, graphic designer Juliette Bellocq and I have developed a set of writing exercises that address these two limitations, as I have come to know writing from my training as an academic. In this piece, we share our exercise, 1,000 Ways Home. It is a non-linear process of thinking and writing. It also offers the alchemy of communicating in the presence of another person who pays close attention. We call our process speak-to-write.
Development of a novel prediction model based on protein structure for identifying RPE65-associated inherited retinal disease (IRDs) of missense variants
Authors: Wu Jiawen , Sun Zhongmou , Zhang Dao wei , Liu Hong-Li , Li Ting , Zhang Shenghai , Wu Jihong 
Published: August 2023

Purpose
This study aimed to develop a prediction model to classify RPE65-mediated inherited retinal disease (IRDs) based on protein secondary structure and to analyze phenotype-protein structure correlations of RPE65 missense variants in a Chinese cohort.

Methods
Pathogenic or likely pathogenic missense variants of RPE65 were obtained from UniProt, ClinVar, and HGMD databases. The three-dimensional structure of RPE65 was retrieved from the Protein Data Bank (PDB) and modified with Pymol software. A novel prediction model was developed using LASSO regression and multivariate logistic regression to identify RPE65-associated IRDs. A total of 21 Chinese probands with RPE65 variants were collected to analyze phenotype-protein structure correlations of RPE65 missense variants.

Results
The study found that both pathogenic and population missense variants were associated with structural features of RPE65. Pathogenic variants were linked to sheet, β-sheet, strands, β-hairpins, Fe2+ (iron center), and active site cavity, while population variants were related to helix, loop, helices, and helix–helix interactions. The novel prediction model showed accuracy and confidence in predicting the disease type of RPE65 variants (AUC = 0.7531). The study identified 25 missense variants in Chinese patients, accounting for 72.4% of total mutations. A significant correlation was observed between clinical characteristics of RPE65-associated IRDs and changes in amino acid type, specifically for missense variants of F8 (H68Y, P419S).

Conclusion
The study developed a novel prediction model based on the protein structure of RPE65 and investigated phenotype-protein structure correlations of RPE65 missense variants in a Chinese cohort. The findings provide insights into the precise diagnosis of RPE65-mutated IRDs.
Effect of POLY4 Application on the Growth and Yield of Groundnut (Arachis hypogaea L.)
Authors: Sunitha B. , Gopinath K. A. , Kumari V. Visha , Ramanjaneyulu A. V. , Suvana S. 
Published: August 2023

Aim: To evaluate the effect of POLY4 Application on the Growth and Yield of Groundnut.
Study Design: Randomized Block Design.
Place and Duration of Study: Gungal Research Farm, ICAR-Central Research Institute for Dry land Agriculture, Hyderabad, India between June 2022 and October 2022.
Methodology: A field experiment was conducted at Gungal Research Farm, ICAR-Central Research Institute for Dry land Agriculture, Hyderabad, and Telangana during the Kharif season of 2022 to the evaluate the Impact of POLY4 Application on the Growth and Yield of Groundnut. The experiment was assigned in ten treatments, laid out in Randomized Block design with three replications. The treatments were T1-Recommended NPK (20:40:50 kg ha-1) + gypsum @ 500 kg ha-1, T2-Recommended NP only, T3-Recommended NPK, T4-Recommended NP + 50% K through MOP, T5-Recommended NP + 100% of rec. K through Poly4, T6-Recommended NP + 100% of rec. K through Poly4 + gypsum @ 310 kg ha-1, T7-Recommended NP + 50% of rec. K through Poly4, T8-Recommended NP + 50% of rec. K through Poly4 + gypsum @ 310 kg ha-1, T9-Recommended NP + gypsum @ 500 kg ha-1 and T10-Control.
Results: The application of Recommended NP(20:40 kg ha-1) + 100% of rec. K(50 kg ha-1) through POLY4 (T5) treatment resulted in a significant increase in both plant height and leaf area at vegetative (18.1 cm and 320.4 cm2 plant-1), at flowering (31.9 cm and 554.7 cm2 plant-1),at pegging (39.5 cm and 785.3 cm2 plant-1), at pod formation (48.5 cm and 1088.5 cm2 plant-1), and at the harvest (54.4 cm and 359.5 cm2 plant-1) respectively compared to the control. Significantly higher pod yield (1556 kg ha-1) was recorded under Recommended NP (20:40 kg ha-1) + 100% K (50 kg ha-1) through POLY4 (T5). The lower yield (844 kg ha-1) was recorded in control (T10).
Conclusion: Polyhalite, also known as POLY4, is a highly effective fertilizer that provides potassium (K), sulfur (S), magnesium (Mg), and calcium (Ca) in a more efficient manner compared to equivalent soluble salts. Based on the findings of the current study, it can be concluded that application of 100% K through polyhalite (POLY4) along with recommended doses of nitrogen and phosphorus (20:40 kg ha-1) in sandy loam soil was the best performing treatment.
Pneumocephalous: Radiological Presentation of Intra-cranial Hypotension after Spinal Anaesthesia
Authors: Khan Isra , Alvi Emad , Khalid Saifullah , Khanam Sameera , Mohammad Saad , Khan Mohammad Nasim 
Published: August 2023

Pneumocephalus is a commonly encountered entity in patients of head trauma and post-op cases of neurosurgery, however it is rarely observed after spinal anaesthesia.
It commonly presents orthostatic hypotension associated with severe headache, nausea and vomiting. We report a case of pneumocephalus following spinal anaesthesia administered for open hernia repair.
The proposed mechanisms of pneumocephalus secondary to spinal tapping are the ball-valve mechanism (1) and the inverted soda-bottle effect (2).
Mitochondrial DNA Fragmentation and Risk of Non-Hodgkin Lymphoma
Authors: Hosgood H. Dean , Davitt Meghan , Cawthon Richard , Weinstein Stephanie J. , Blechter Batel , Wong Jason Y.Y. , Rahman Mohammad L. , Hu Wei , Männistö Satu , Albanes Demetrius , Rothman Nathaniel , Lan Qing 
Published: August 2023

ImportanceResearch suggests that increased mitochondrial DNA copy number (mtDNAcn) is associated with increased risk of non-Hodgkin lymphoma (NHL); however, no studies to date have evaluated whether the mitochondrial DNA fraction with breaks (mtDNAfb) is associated with risk of NHL.ObjectiveTo evaluate the association of mtDNAfb with NHL risk.Design, Setting, and ParticipantsThis nested case-control study, which used prospectively collected samples as part of baseline enrollment (from 1985 through 1988) of 29 133 men who smoked for the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study conducted in southwest Finland, included 107 incident NHL cases and 107 controls (matched on date of birth ±5 years). Analyses were conducted from January to September 2022.ExposureHigh-throughput real-time polymerase chain reaction assays quantifying mtDNAfb.Main Outcomes and MeasuresIncident NHL cases were identified in the ATBC Study through April 30, 2002, using the Finnish Cancer Registry and the Register of Causes of Death. The mtDNAfb was quantified and categorized based on the median, tertile, and quartile distributions among controls. Odds ratios (ORs) and 95% CIs were estimated using conditional logistic regression models to assess the associations between categorized mtDNAfb and future risk of NHL, controlling for age, body mass index, number of cigarettes smoked per day, number of pack-years, and mtDNAcn.ResultsA total of 29 133 men (median [IQR] age, 57.2 [52.6-62.5] years) participated in ATBC Study. Higher mtDNAfb was associated with an increased risk of NHL (median OR, 2.89; 95% CI, 1.40-5.93) in a dose-dependent manner (quartile 2 vs 1 OR, 1.24; 95% CI, 0.43-3.40; quartile 3 vs 1 OR, 3.58; 95% CI, 1.39-9.24; quartile 4 vs 1 OR, 3.42; 95% CI, 1.30- 8.99; P = .004 for trend).Conclusions and RelevanceThis study’s findings suggest that increased mtDNAfb is associated with an increased future risk of NHL. Additional studies are needed to confirm these findings, particularly among women and nonsmokers.
Abdominal Pain After Roux-en-Y Gastric Bypass
Authors: Fry Brian T. , Finks Jonathan F. 
Published: August 2023

ImportanceRoux-en-Y gastric bypass (RYGB) remains one of the most commonly performed operations for morbid obesity and is associated with significant long-term weight loss and comorbidity remission. However, health care utilization rates following RYGB are high and abdominal pain is reported as the most common presenting symptom for those seeking care.ObservationsGiven the limitations of physical examination in patients with obesity, correct diagnosis of abdominal pain following RYGB depends on a careful history and appropriate use of radiologic, laboratory and endoscopic studies, as well as a clear understanding of post-RYGB anatomy. The most common etiologies of abdominal pain after RYGB are internal hernia, marginal ulcer, biliary disease (eg, cholelithiasis and choledocholithiasis), and jejunojejunal anastomotic issues. Early identification of the etiology of the pain is essential, as some causes, such as internal hernia or perforated gastrojejunal ulcer, may require urgent or emergent intervention to avoid significant morbidity. While laboratory findings and imaging may prove useful, they remain imperfect, and clinical judgment should always be used to determine if surgical exploration is warranted.Conclusions and RelevanceThe etiologies of abdominal pain after RYGB range from the relatively benign to potentially life-threatening. This Review highlights the importance of understanding key anatomical and technical aspects of RYGB to guide appropriate workup, diagnosis, and treatment.
Intraoperative Identification of Thyroid and Parathyroid Tissues During Human Endocrine Surgery Using the MasSpec Pen
Authors: DeHoog Rachel J. , King Mary E. , Keating Michael F. , Zhang Jialing , Sans Marta , Feider Clara L. , Garza Kyana Y. , Bensussan Alena , Krieger Anna , Lin John Q. , Badal Sunil , Alore Elizabeth , Pirko Christopher , Brahmbhatt Kirtan , Yu Wendong , Grogan Raymon , Eberlin Livia S. , Suliburk James 
Published: August 2023

ImportanceIntraoperative identification of tissues through gross inspection during thyroid and parathyroid surgery is challenging yet essential for preserving healthy tissue and improving outcomes for patients.ObjectiveTo evaluate the performance and clinical applicability of the MasSpec Pen (MSPen) technology for discriminating thyroid, parathyroid, and lymph node tissues intraoperatively.Design, Setting, and ParticipantsIn this diagnostic/prognostic study, the MSPen was used to analyze 184 fresh-frozen thyroid, parathyroid, and lymph node tissues in the laboratory and translated to the operating room to enable in vivo and ex vivo tissue analysis by endocrine surgeons in 102 patients undergoing thyroidectomy and parathyroidectomy procedures. This diagnostic study was conducted between August 2017 and March 2020. Fresh-frozen tissues were analyzed in a laboratory. Clinical analyses occurred in an operating room at an academic medical center. Of the analyses performed on 184 fresh-frozen tissues, 131 were included based on sufficient signal and postanalysis pathologic diagnosis. From clinical tests, 102 patients undergoing surgery were included. A total of 1015 intraoperative analyses were performed, with 269 analyses subject to statistical classification. Statistical classifiers for discriminating thyroid, parathyroid, and lymph node tissues were generated using training sets comprising both laboratory and intraoperative data and evaluated on an independent test set of intraoperative data. Data were analyzed from July to December 2022.Main Outcomes and MeasuresAccuracy for each tissue type was measured for classification models discriminating thyroid, parathyroid, and lymph node tissues using MSPen data compared to gross analysis and final pathology results.ResultsOf the 102 patients in the intraoperative study, 80 were female (78%) and the median (IQR) age was 52 (42-66) years. For discriminating thyroid and parathyroid tissues, an overall accuracy, defined as agreement with pathology, of 92.4% (95% CI, 87.7-95.4) was achieved using MSPen data, with 82.6% (95% CI, 76.5-87.4) accuracy achieved for the independent test set. For distinguishing thyroid from lymph node and parathyroid from lymph node, overall training set accuracies of 97.5% (95% CI, 92.8-99.1) and 96.1% (95% CI, 91.2-98.3), respectively, were achieved.Conclusions and RelevanceIn this study, the MSPen showed high performance for discriminating thyroid, parathyroid, and lymph node tissues intraoperatively, suggesting this technology may be useful for providing near real-time feedback on tissue type to aid in surgical decision-making.
The effects of flattening filter‐free beams and aperture shape controller on the complexity of conventional large‐field treatment plans
Authors: Hui Cheukkai B. , Pourmoghaddas Amir , Mutaf Yildirim D. 
Published: August 2023

AbstractPurposeThe purpose of this study was to investigate the impact of using flattening filter‐free (FFF) beams and the aperture shape controller (ASC) on the complexity of conventional large‐field treatment plans.Methods and materialsA total of 24 head and neck (H&N) and 24 prostate with pelvic nodes treatment plans were used in this study. Each plan was reoptimized using the original clinical objectives with both flattened and FFF beams, as well as six different ASC settings. The dosimetric qualities of each plan cohort were evaluated using commonly used dose‐volume histogram values, and plan complexities were assessed through metrics including monitor unit (MU)/Dose, change in gantry speed, multileaf collimator (MLC) speed, the edge area ratio metric (EM), and the equivalent square length.ResultsNo significant differences in dosimetric qualities were found between plans with flattened and FFF beams. The ASC settings did not have significant effects on dosimetric qualities in the H&N plan cohort, but the “very high” ASC setting resulted in poorer dosimetric results for the prostate plans. Plans with FFF beams had significantly higher MU/Dose compared to plans with flattened beams. The use of flattening filter (FF) had significant effects on the change in gantry speed, with flattened beams producing plans that required higher change in gantry speed. However, the FF did not have significant effects on MLC speed, EM, or equivalent square length. In contrast, ASC settings had significant effects on these three metrics; increasing the ASC level resulted in plans with decreasing MLC speed, lower edge area ratio, and higher equivalent square length.ConclusionThis study demonstrated that using FFF beams with various ASC settings, except for the “very high” level, can produce plans with reduced complexities without compromising dosimetric qualities in conventional large‐field treatment plans.
Unpredictably Disordered Distribution of Hetero‐Blended Graphene Oxide Flakes with Non‐Identical Resistance in Physical Unclonable Functions
Authors: Lee Subin , Choi Seon Yeon , Jang Byung Chul , Lee Dong Hyun , Cho Joon Young , Han Joong Tark , Yoo Hocheon , Kim Hyun Ho 
Published: August 2023

AbstractIn this study, a new concept of physical unclonable functions (PUFs) is introduced comprising reduced graphene oxide (GO) materials. To create a disordered conductivity distribution, two types of GO are used: HGO, are produced by the conventional Hummers’ method, and PGO, produced by Brodie's method with an additional unique purification procedure. It is found that PGO becomes graphene‐like after room‐temperature chemical reduction. These two reduced GOs have a distinct conductivity difference of up to 104 times. By blending these two materials, a random mixture is created that can generate a highly unpredictable electrical signal, serving as an ideal security key with strong randomness and uniqueness. The optimized PUF device, based on this approach, demonstrates excellent performance in generating secure keys.
Localized Spoof Surface Plasmon Skyrmions Excited by Guided Waves
Authors: Li Si‐Qi , Du Chao‐Hai , Yin Da‐Li , Cai Xin‐Wei , Xu Tie‐Quan , Wang Yue , Li Fan‐Hong , Zhu Yu , Zhang Feng 
Published: August 2023

AbstractRecently, skyrmions are constructed in the system of localized spoof surface plasmons (LSSPs), showing topological robustness and near‐equidistant multi‐resonant response. Guided wave excitation of the LSSP skyrmions plays an elementary role in large‐scale planar integration and construction of complex networks. However, it is not investigated. In this study, the LSSP skyrmions are excited by guided waves supported by two kinds of widely used transmission lines, microstrip line and coplanar waveguide. Space‐coiling meta‐structures with different shapes that support LSSP skyrmions are etched on the ground planes as defected ground structures (DGSs). All structures including resonator, transmission line, input and output ports are in one plane. The structures are fabricated on printed circuit boards (PCBs) and the near‐equidistant multi‐resonant spectra of the LSSP skyrmions are measured. Moreover, to reduce the material loss, the structure is made on MgB2 superconducting film, and the quality factor (Q‐factor) is increased by seven times compared to the corresponding mode on PCB. This study paves the way for the massive planar integration of the LSSP skyrmions and the construction of complex networks with the LSSP skyrmions, and provides an idea for developing metasurfaces with low material loss in the microwave and terahertz bands.
Virus‐Like Nanotherapeutic for Spatiotemporally Enhancing Antigen Presentation and Cross‐Presentation toward Potential Personalized Immunotherapy
Authors: Li Xiaodi , Yuan Pengfei , Yang Haiyuan , Zong Xiaoqing , Yang Caiqi , Chen Xinjie , Li Yuchao , Yan Xiaodie , Wen Yaoqi , Zhu Tianci , Zhang Qian , Xue Wei , Dai Jian 
Published: August 2023

AbstractOne of the major causes of immunotherapy resistance is the loss of major histocompatibility complex class I (MHC‐I) molecules in tumor cells or the downregulation of the class I antigen presentation pathway. In this study, a novel virus‐like nanotherapeutic (siRNA@HCM) is developed via encapsulating nanosized siRNA nanoparticles in a hybrid membrane comprising a personalized tumor cell membrane and a universal 293T membrane expressing the mutant vesicular stomatitis virus glycoprotein (mVSV‐G). Upon intravenous administration, siRNA@HCM accumulates at the tumor site and provides two potent driving forces for antitumor immunity. First, mVSV‐G induces the fusion of siRNA@HCM with tumor cell membranes and directly injects siRNAs into the cytoplasm, significantly improving tumor intrinsic MHC‐I antigen presentation. Moreover, mVSV‐G can promote the maturation of dendritic cells, thereby achieving highly efficient antigen cross‐presentation. The results demonstrate that spatiotemporally enhancing tumor intrinsic antigen presentation and cross‐presentation via siRNA@HCM can achieve satisfactory antitumor efficacy and excellent biocompatibility. Immune infiltration analysis shows that siRNA@HCM treatment turns cold tumors into hot tumors. In addition, it significantly promotes the therapeutic effect of programmed death‐1 inhibitor. In summary, virus‐like nanotherapeutics present a promising approach to enhance the antitumor immune response, with distinct advantages for potential personalized therapy and clinical applications.