bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depletion assisted hemin affinity (DAsHA) proteomics reveals an expanded landscape of heme-binding proteins in the human proteome
Authors: Kim Hyojung , Moore Courtney M , Mestre-Fos Santi , Hanna David A , Williams Loren Dean , Reddi Amit R , Torres Matthew P 
Published: January 2023

Abstract
Heme b (iron protoporphyrin IX) plays important roles in biology as a metallocofactor and signaling molecule. However, the targets of heme signaling and the network of proteins that mediate the exchange of heme from sites of synthesis or uptake to heme dependent or regulated proteins are poorly understood. Herein, we describe a quantitative mass spectrometry (MS)-based chemoproteomics strategy to identify exchange labile hemoproteins in human embryonic kidney HEK293 cells that may be relevant to heme signaling and trafficking. The strategy involves depleting endogenous heme with the heme biosynthetic inhibitor succinylacetone (SA), leaving putative heme-binding proteins in their apo-state, followed by the capture of those proteins using hemin–agarose resin, and finally elution and identification by MS. By identifying only those proteins that interact with high specificity to hemin–agarose relative to control beaded agarose in an SA-dependent manner, we have expanded the number of proteins and ontologies that may be involved in binding and buffering labile heme or are targets of heme signaling. Notably, these include proteins involved in chromatin remodeling, DNA damage response, RNA splicing, cytoskeletal organization, and vesicular trafficking, many of which have been associated with heme through complementary studies published recently. Taken together, these results provide support for the emerging role of heme in an expanded set of cellular processes from genome integrity to protein trafficking and beyond.
Acute kidney injury in bortezomib-treated patients with multiple myeloma
Authors: Song Seung Min , Jeon Junseok , Jang Hye Ryoun , Kim Kihyun , Huh Wooseong , Kim Yoon-Goo , Lee Jung Eun 
Published: January 2023

ABSTRACT

Background
The nephrotoxicity of bortezomib, a proteasome inhibitor, has not yet been elucidated, although tumor lysis syndrome (TLS) associated with multiple myeloma (MM) has been reported to increase after introduction of the drug. This study compared the incidence and risk factors for acute kidney injury (AKI) and TLS in patients with MM after bortezomib-based chemotherapy to investigate drug-related nephrotoxicity.

Methods
From 2006 to 2017, 276 patients who underwent a first cycle of bortezomib-based chemotherapy for MM were identified in a single tertiary hospital. Laboratory TLS was defined according to the Cairo-Bishop definition. Development of AKI was assessed by AKI Network criteria within 7 days of the first chemotherapy.

Results
The median (interquartile range) age was 65 (56–72) years, and baseline estimated glomerular filtration rate (eGFR) was 61.3 (34.1–89.1) mL/min/1.73 m2. The incidences of AKI and laboratory TLS were 17% (n = 47) and 13% (n = 36), respectively. Ten (3.6%) subjects met both AKI and TLS criteria. Multivariate analyses showed that lower eGFR category [30–59, odds ratio (OR) 3.005 (95% confidence interval 1.163–7.976); 15–29, OR 4.225 (1.183–15.000); &lt;15, OR 16.154 (3.831–70.920) vs ≥60, P &lt; .001], lower serum albumin level [per 1 increase, OR 0.479 (0.256–0.871), P = .018], renal amyloidosis [OR 13.039 (4.108–44.041), P &lt; .001] and use of acyclovir during bortezomib treatment [OR 3.689 (1.133–14.469), P = .042] were predictors of AKI. MM stages and β-2-microglobulin were not associated with increased risk of AKI. Regarding laboratory TLS, MM stage and β-2-microglobulin were higher in those with TLS than in others. In multivariate analyses, β-2-microglobulin level [OR 1.204 (1.005–1.461), P = .038] and absence of high-risk chromosome abnormalities [OR 0.143 (0.022–0.588), P = .016] were associated with higher risk of TLS.

Conclusions
Development of AKI was often observed in the absence of TLS in patients with MM after treatment with bortezomib. In addition, the risk factors for AKI and TLS varied widely. These findings indicate the potential nephrotoxicity of bortezomib irrespective of TLS in patients with decreased kidney function.
The Grand Bargain
Authors: Brakman Reiser Dana , Dean Steven A. 
Published: January 2023

Abstract
This chapter looks back to the last major US effort to broker a truce between elites and the public: the Tax Reform Act of 1969. Gilded-age industrialists like Rockefeller and Carnegie pioneered the concept of a philanthropic foundation, designed to manage and give away capital as a charitable antithesis of a hedge fund. By mid-century, public skepticism ran high, fueled by perceived abuses within these organizations. High-profile inquiries paved the way to major reform legislation. This Grand Bargain offered wealthy donors an opportunity to make robust commitments to do good through “private foundations” while retaining the privilege of perpetual life and considerable autonomy along with valuable promises of tax forbearance at the cost of government regulation and transparency. The regulatory regime that emerged from this Grand Bargain channeled philanthropic activity toward public-regarding activities and at least some significant current spending and away from entanglements with business interests and politics.
In Search of Lost Trust
Authors: Brakman Reiser Dana , Dean Steven A. 
Published: January 2023

Abstract
This chapter explores the risks of undermining the delicate truce the Grand Bargain employed to bolster public trust in philanthropy. A look at adjacent innovations in social enterprise governance and ESG investing reveals the dangers in undermining that trust, whether it be feast or famine. The tepid embrace of social enterprise forms reminds us there are limits to the public’s willingness to take the powerful at their word. When philanthropy limited liability companies, commercially affiliated donor-advised funds, or strategic corporate philanthropists exaggerate their impact, or conflate self-interest with the public interest, blowback may not be limited to these innovative players. In contrast, investors flooding into ESG funds appear convinced trust is irrelevant; financial return and social and environmental progress neatly coincide. For-profit philanthropy’s embrace of the same cavalier attitude toward trust risks crowding out charitable efforts that fail to neatly align with commerce, and the halo of the entire philanthropic sector along with it.
Private Ordering Solutions
Authors: Brakman Reiser Dana , Dean Steven A. 
Published: January 2023

Abstract
This chapter invites wealthy elites to act strategically to reinforce the trust the Grand Bargain once secured, even without government enforcement. The private sector has, after all, fueled the innovation on display in the rise of philanthropy limited liability companies (LLCs), commercially affiliated donor-advised funds, and strategic corporate philanthropy. Perhaps it can also tame those creations to build a more accountable for-profit philanthropy to forestall the risk that public skepticism will smother it. Much of charity law can be described as tools to demonstrate trustworthiness. Rather than relying on policymakers to supply the trust for-profit philanthropy needs, careful private ordering could reveal corporate philanthropists, commercially affiliated donor-advised funds, and philanthropy LLCs to be uniquely capable of saving themselves. A precisely tailored corporate governance scheme for strategic corporate philanthropy, a contractual dead man’s switch for donor-advised funds, and self-enforcing transparency agreements for philanthropy LLCs could mitigate the risks they impose while unleashing their potential value.
A More Perfect Bargain
Authors: Brakman Reiser Dana , Dean Steven A. 
Published: January 2023

Abstract
This chapter’s three visions for systemic reform all combat the pervasive timing, transparency, and targeting threats posed by the rise of for-profit philanthropy. First, it tests the lens of income. A return to steeply progressive mid-century tax rates combined with tempering the myriad tax loopholes that favor wealthy taxpayers represents one path toward reining in elite influence. The second systemic reform approach views inequality not as a function of income but of wealth. Threatening wealth with a new tax creates new opportunities to encourage accountable philanthropy. Finally, acknowledging that the Grand Bargain ultimately represented a strategic compromise with—rather than a tax on—elites, the last approach turns in an entirely new direction. Redistributing political power rather than revenues could create a new partnership between elites and the public. The More Perfect Bargain it describes would aim to do just that.
Contexts, Cultures, and Constraints
Authors: Lawson Robert 
Published: January 2023

Abstract
Chapter 1 introduces the main focus of the book, outlining the background of the book and explaining how a linguistic analysis of male-dominated media contexts can shed light on processes of discrimination, inequality, and affiliation in different online and offline media spaces, including newspapers, forums, social media sites, and television shows. The chapter goes on to situate the book against the broader backdrop of masculinities studies and relates later chapters to existing work in the field, such as hegemonic masculinity, toxic masculinity, caring masculinity, and other relevant frameworks. The chapter then introduces the rationale and motivation for the book, before ending with an overview of the remaining chapters.
“Man, woman, birth, death, infinity”Drama
Authors: Burlingame Jon 
Published: January 2023

Abstract
Television drama has inspired a wide variety of styles and colors of music. Nelson Riddle and Jerry Goldsmith enjoyed chart hits from their Route 66 and Dr. Kildare themes; a Moog synthesizer was used in the Medical Center theme, and the entire pilot of St. Elsewhere was created using electronic means; ER had both synths and electric guitar. Lawyer shows range from a mild R&B treatment (Perry Mason) to fanfares for the law (The Defenders) to dignified French horns meet sexy saxophone (L.A. Law). War series merit dissonance (Combat), an anthem (12 O’Clock High), and even gentle guitars (M*A*S*H). Anthologies are where John Williams learned his trade (Alcoa Premiere, Kraft Suspense Theatre). Homespun Americana served The Waltons, while dignified contemporary Americana worked for The West Wing; Dallas and Dynasty, meanwhile, merited a touch of disco and a lot of elegance. In the new century, a hint of irony via orchestra and choir seemed right for Desperate Housewives. Umbrella themes attracted such major musical names as Burt Bacharach, Isaac Hayes, and Henry Mancini.
“Flintstones! Meet the Flintstones!”Cartoons in Prime Time
Authors: Burlingame Jon 
Published: January 2023

Abstract
Hoyt Curtin, architect of the Hanna-Barbera sound, created indelible theme songs for The Flintstones, Jetsons, Top Cat, and Jonny Quest. TV’s Bugs Bunny Show showcased the greatest curtain-raiser of all with “This Is It!” Jay Ward’s Rocky and Bullwinkle featured fun music. Vince Guaraldi’s piano-based jazz for the Peanuts specials, starting with “A Charlie Brown Christmas,” became iconic. The Simpsons became one of the longest-running prime-time series ever, with a 1960s-inspired theme by Danny Elfman and hundreds of smart scores by Alf Clausen (until he was fired). The animated Batman, Superman, Justice League, and other DC heroes won Emmys for their music. Seth MacFarlane’s Family Guy featured large orchestras and Broadway-style numbers. The Rankin-Bass holiday specials (starting with “Rudolph the Red-Nosed Reindeer”) were distinguished by warm and appropriate scores by Maury Laws.
Digital Grooming
Authors: Lorenzo-Dus Nuria 
Published: January 2023

AbstractThis book examines digital grooming as a discourse manipulation practice in digital spaces that are situated at, or beyond, the boundaries of law. It identifies and examines in detail the online discourse of adults’ luring of children for sexual abuse and exploitation (digital sexual grooming), extreme ideology groups’ aligning others to their views (digital ideological grooming), and drug dealers’ transactional endeavors in crypto markets (digital commercial grooming). Style and stance analyses of large and varied datasets reveal that digital sexual, ideological, and commercial groomers’ practices have more in common than not. Three stances—expertise, openness, and avidity—scaffold their manipulative work, which relies upon and constructs identity homogenization. Digital groomers’ discourse seeks to construct them and their targets as inhabiting a perfectly aligned ideological, affective, and overall identity space. The better aligned they are, the more likely it is that they will see themselves as being misaligned from other equally homogenously constructed, identities: their opponents. The findings of this book can inform practitioner-based attempts at countering digital grooming, including development of detection software and prevention-focused training resources.
Digital Grooming
Authors: Lorenzo-Dus Nuria 
Published: January 2023

AbstractThis chapter starts by providing a working definition for digital grooming, informed in part by its etymological evolution. It then maps the conceptual territory of digital grooming across three core features: digital mediation, manipulation, and identity construction. It argues that the “digitalness” of digital grooming is constitutive of it rather than merely contextual. A digital communication context marked by a celebration of sharing, a transformation of the value of trust, and the search for continued engagement/influence within fluid participation frameworks underpin the digital mediation of grooming as a criminal activity. The chapter then reviews key approaches to the broader concept of manipulation, as well as its constitutive features and the crucial part played by identity in digital grooming. This starts by considering the impact of networked publics, vis-à-vis pre-digital conceptualizations of participation frameworks, on how digital groomers position themselves in relation to those individuals and groups they seek to manipulate. Across these spaces, the chapter contends, digital groomers mobilize stances to style their personae and those of their target and perceived opponents in strategic ways that advance their manipulative goals.
Digital Ideological Grooming
Authors: Lorenzo-Dus Nuria 
Published: January 2023

AbstractChapter 5 critically engages the academic/practitioner debate regarding the religious and/or political motivations of extremists. The chapter contends that these motivations operate symbiotically, which in turn suggests that the digital manipulation strategies of extremist groups across the ideological spectrum can be expected to exhibit similarities as well as differences. Both jihadi and radical-right groups make intelligent use of diverse digital spaces, moving across them in agile ways in response to new opportunities and threats. Jihadi and radical right groups also share high entitativity, and, in both cases polarized ideology is central to this. Indeed, for both jihadi and radical right groups, the dominant objective of their digital modus operandi is community building as the locus for identity construction, specifically the ideological formation of in-groups that are bound together through their active vilification of out-groups. This chapter thus sets the scene for the analysis, in Chapter 6, of the strategic performance of digital ideological grooming, specifically groomers’ styling of themselves, their target and their opponents.
“Let Them Starve, You Idiots!!! Why Feed VERMIN?”
Authors: Lorenzo-Dus Nuria 
Published: January 2023

AbstractDigital ideological grooming relies primarily on argumentative polarization of social identities. In-group/out-group boundaries are clear-cut and diametrically opposed. Self-styling in digital ideological grooming supports this through e stances: broad expertise, toxic openness and impatient avidity. Broad expertise enables having a say about any issue, piggybacking on it as a means to present the in-group’s ideology. Toxic openness relies on mythopoesis, specifically first-person storytelling that highlights stereotypically—toxic—masculine emotions of anger. The groomers’ anger is rooted in perceived victimization and supports a logic of retaliation against the out-group. Impatient avidity entails convening a pressing call to action. In digital ideological grooming, groomer and target are regularly constructed as part of the same inner group, one to which the target may already belong or may join. This in-group is styled through stances that complement the groomers’. Overall, the virtues and strengths of in-group as target are profusely extolled. Occasionally, selective dissociation processes are also enacted whereby the target is presented as ideologically lacking. The chapter demonstrates styling of opponents is pervasive and varied. Both jihadi and radical right groups’ messaging construct multiple out-groups, which are othered, primarily via face-oriented and equity rights–oriented impoliteness. Insults, criticism/complaints, and threats are made to serve morality-based drivers such as distributive justice or an imperative to act urgently in the face of long-endured in-group victimization.
“Your DrugBuddy”
Authors: Lorenzo-Dus Nuria 
Published: January 2023

AbstractThe chapter’s analysis shows that Silk Road vendors went to considerable lengths to show keen interest in customers, typically presented as seeking to protect the Silk Road community from being tracked by law enforcement, scammed by other vendors, and subjected to drug-related harm. As part of their self-styling as experts, Silk Road users regularly shared externally (i.e., scientific) and internally (i.e., personal experience) sourced knowledge about drug use and dealing. By constructing a stance of openness, Silk Road users displayed business acumen (especially in the vendor profile pages). Styling of the target relied on stances of drug savviness and pleasantness that, respectively, catered to projected identities of Silk Road customers and fellow community members. Targets of digital commercial grooming were related to via deference (as customers) and interpersonal closeness (as fellow community members). As an illicit digital market, Silk Road was itself the target of efforts to detect and exploit its activity. Law enforcement and fraudulent vendors were constructed as its opponents. Law enforcement represented the state and, as such, constituted a direct challenge to Silk Road’s libertarian ethos. Styling of this enemy was primarily undertaken in the site’s forums, often instigated by the market’s administrator, and generally made use of moderate face-threat. In contrast, fraudulent vendors were othered through impoliteness oriented toward face (insults) and equity (belittling) rights. The strength of expression against these internal opponents was legitimated on community-based grounds, mainly lack of integrity as vendors (e.g., scams) and not being respectful to other market users.
The Priority of Responsibility over Repair
Authors: Keating Gregory C. 
Published: January 2023

Abstract
For more than a generation, normatively inclined tort theory has been forged in the crucible of a struggle between two competing visions of the subject. Legal economists have articulated an uncompromisingly forward-looking conception of tort law as a shadow price system designed to minimize the combined costs of accidents and their avoidance. Tortfeasors and tortious wrongs are imperfect surrogates for cheapest cost-avoiders and avoidable future losses. Corrective justice theory has replied that torts is a law of wrongs and rights, and that the economic account of tort adjudication as a search for cheapest cost-avoiders going forward simply denies the basic features of tort adjudication. We hold defendants liable in tort when and because they have wronged their victims and should therefore repair the harm they have done. The backward gaze of the ordinary tort lawsuit confirms the fact that the law of torts is a law of responsibility for harm wrongly done. Chapter Two argues that the corrective justice critique hits its target but overshoots the mark in doing so. Tort is a law of wrongs, not just a law of redress for wrongs. Repairing harm wrongly done is the next best way of complying with an obligation not to do harm wrongly in the first place. Rights and remedies form a unity in which rights, not remedies, have priority. Corrective justice and civil recourse are thus essential but subordinate aspects of tort. Tort law’s primary norms are the heart and soul of the field.
From Reparation to Regulation
Authors: Keating Gregory C. 
Published: January 2023

Abstract
Tort law safeguards security by requiring reparation for harm wrongly done. Some harms, however, are irreparable. Death is the most vivid case in point. No amount, or form, of compensation can restore the dead to the lives they have lost. The harm of death exposes tort law’s Achilles heel. On the one hand, premature death is the harm that we most wish to be protected against. On the other hand, premature death is the harm against which tort law is least able to protect us. Tort law relies on reparation to enforce its obligations, both prospectively and retrospectively. When wrongful death is at issue, reparation fails. Direct regulation of risk is required to remedy the incompleteness of tort law. Chapter Five therefore takes up regulatory standards which address risks of injury so severe that reparation after the fact cannot restore normal powers of human agency to victims who suffer such harms. Characteristically, these standards prescribe more than efficient precaution. The prevailing academic wisdom is that these standards are irrational because they require inefficiently stringent precaution. The rational way to trade costs off against benefits is to balance them so that we maximize net value and thereby make ourselves as well off as we can be. Taking more than efficient precaution yields less—not more—value. Chapter Five argues that physical harm has special, negative importance because it is an essential condition of effective agency. Harm’s avoidance therefore has special priority; that priority justifies the safety and feasibility standards.