bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization and Geological Meaning of the Crystalline Basement Occurrence in the Unaí Region, Minas Gerais State (Central Brasilia Belt)
Authors: Moura Florença Das Graças , Campos José Eloi Guimarães 
Published: September 2023

Granitoid rocks petrographically and compositionally characterized as tonalite, monzonite granodiorite and granite were observed in restricted areas in the central portion of the external zone of the Brasilia Belt. These outcrops of peraluminous rocks were interpreted as the sialic basement of the region, associated with paleogeographic highs prior to the deposition of the Proterozoic sedimentary cover. U-Pb zircon age of 2.14 Ga and geochemical analysis are compatible with other Paleoproterozoic bedrock areas observed mainly in the north Brasilia Belt. The existence of a basement bulkhead conditioned the Neoproterozoic deformation, causing the inflection of regional structures from NNW to N60-70W and over again to the NNW regional trend. The absence of contact metamorphism along the adjacent supracrustal rocks, regional foliation attitude that is different from that observed in the granitoids (tonalite, granotiorite, monzonite and granite) and the older age, show that these rocks represent basement windows and not younger intrusive bodies, as previously interpreted. The rocks studied in this research are correlated to the Aurumina Suite, which represents the main basement rock set in the North Brasília Belt.
To Sleep Dreaming Medals: Sleep Characteristics, Napping Behavior, and Sleep-Hygiene Strategies in Elite Track-and-Field Athletes Facing the Olympic Games of Tokyo 2021
Authors: Vitale Jacopo A. , Borghi Stefano , Piacentini Maria Francesca , Banfi Giuseppe , La Torre Antonio 
Published: September 2023

Purpose: Few data are available on sleep characteristics of elite track-and-field athletes. Our study aimed to assess (1) differences in sleep between sexes and among different track-and-field disciplines, (2) the effect of individualized sleep-hygiene strategies on athletes’ sleep parameters, and (3) daytime nap characteristics in track-and-field athletes. Methods: Sleep characteristics of 16 elite Olympic-level track-and-field athletes (male: n = 8; female: n = 8) were assessed during the preseason period, at baseline (T0), and during the in-season period, after the adoption of individualized sleep-hygiene strategies (T1). Sleep parameters were objectively monitored by actigraphy for a minimum of 10 days, for each athlete, at both T0 and T1. A total of 702 nights were analyzed (T0 = 425; T1 = 277). Results: Female athletes displayed better sleep efficiency (88.69 [87.69–89.68] vs 91.72 [90.99–92.45]; P = .003, effect size [ES]: 0.44), lower sleep latency (18.99 [15.97–22.00] vs 6.99 [5.65–8.32]; P < .001, ES: 0.65), higher total sleep time (07:03 [06:56–07:11] vs 07:18 [07:10–07:26]; P = .030, ES: 0.26), earlier bedtime (00:24 [00:16–00:32] vs 00:13 [00:04–00:22]; P = .027, ES: 0.18), and lower nap frequency (P < .001) than male athletes. Long-distance runners had earlier bedtime (00:10 [00:03–00:38] vs 00:36 [00:26–00:46]; P < .001, ES: 0.41) and wake-up time (07:41 [07:36–07:46] vs 08:18 [08:07–08:30]; P < .001, ES: 0.61), higher nap frequency, but lower sleep efficiency (88.79 [87.80–89.77] vs 91.67 [90.95–92.38]; P = .013, ES: 0.44), and longer sleep latency (18.89 [15.94–21.84] vs 6.69 [5.33–8.06]; P < .001, ES: 0.67) than athletes of short-term disciplines. Furthermore, sleep-hygiene strategies had a positive impact on athletes’ total sleep time (429.2 [423.5–434.8] vs 451.4 [444.2–458.6]; P < .001, ES: 0.37) and sleep latency (14.33 [12.34–16.32] vs 10.67 [8.66–12.68]; P = .017, ES: 0.19). Conclusions: Sleep quality and quantity were suboptimal at baseline in Olympic-level track-and-field athletes. Large differences were observed in sleep characteristics between sexes and among different track-and-field disciplines. Given the positive effect of individualized sleep-hygiene strategies on athlete’s sleep, coaches should implement sleep education sessions in the daily routine of top-level athletes.
Influence of soil depth, irrigation, and plant genotype on the soil microbiome, metaphenome, and carbon chemistry
Authors: Naasko Katherine I. , Naylor Daniel , Graham Emily B. , Couvillion Sneha P. , Danczak Robert , Tolic Nikola , Nicora Carrie , Fransen Steven , Tao Haiying , Hofmockel Kirsten S. , Jansson Janet K. 
Published: September 2023

ABSTRACT
Climate change is causing an increase in drought in many soil ecosystems and a loss of soil organic carbon. Calcareous soils may partially mitigate these losses via carbon capture and storage. Here, we aimed to determine how irrigation-supplied soil moisture and perennial plants impact biotic and abiotic soil properties that underpin deep soil carbon chemistry in an unfertilized calcareous soil. Soil was sampled up to 1 m in depth from irrigated and planted field treatments and was analyzed using a suite of omics and chemical analyses. The soil microbial community composition was impacted more by irrigation and plant cover treatments than by soil depth. By contrast, metabolomes, lipidomes, and proteomes differed more with soil depth than treatments. Deep soil (>50 cm) had higher soil pH and calcium concentrations and higher levels of organic acids, bicarbonate, and triacylglycerides. By contrast, surface soil (0–5 cm) had higher concentrations of soil organic matter, organic carbon, oxidizable carbon, and total nitrogen. Surface soils also had higher amounts of sugars, sugar alcohols, phosphocholines, and proteins that reflect osmotic and oxidative stress responses. The lipidome was more responsive to perennial tall wheatgrass treatments compared to the metabolome or proteome, with a striking change in diacylglyceride composition. Permanganate oxidizable carbon was more consistently correlated to metabolites and proteins than soil organic and inorganic carbon and soil organic matter. This study reveals specific compounds that reflect differences in organic, inorganic, and oxidizable soil carbon fractions that are impacted by interactions between irrigation-supplied moisture and plant cover in calcareous soil profiles.

IMPORTANCE
Carbon is cycled through the air, plants, and belowground environment. Understanding soil carbon cycling in deep soil profiles will be important to mitigate climate change. Soil carbon cycling is impacted by water, plants, and soil microorganisms, in addition to soil mineralogy. Measuring biotic and abiotic soil properties provides a perspective of how soil microorganisms interact with the surrounding chemical environment. This study emphasizes the importance of considering biotic interactions with inorganic and oxidizable soil carbon in addition to total organic carbon in carbonate-containing soils for better informing soil carbon management decisions.
Identification and genomic analysis of temperate
Halomonas
bacteriophage vB_HmeY_H4907 from the surface sediment of the Mariana Trench at a depth of 8,900 m
Authors: Su Yue , Zhang Wenjing , Liang Yantao , Wang Hongmin , Liu Yundan , Zheng Kaiyang , Liu Ziqi , Yu Hao , Ren Linyi , Shao Hongbing , Sung Yeong Yik , Mok Wen Jye , Wong Li Lian , Zhang Yu-Zhong , McMinn Andrew , Wang Min 
Published: September 2023

ABSTRACT

Viruses play crucial roles in the ecosystem by modulating the host community structure, mediating biogeochemical cycles, and compensating for the metabolism of host cells. Mariana Trench, the world’s deepest hadal habitat, harbors a variety of unique microorganisms that have adapted to its extreme conditions of low temperatures, high pressure, and nutrient scarcity. However, our knowledge about isolated hadal phage strains in the hadal trench is still limited. This study reported the discovery of a temperate phage, vB_HmeY_H4907, infecting
Halomonas meridiana
H4907, isolated from surface sediment from the Mariana Trench at a depth of 8,900 m. To our best knowledge, it is the deepest isolated siphovirus from the ocean. Its 40,452 bp linear dsDNA genome has 57.64% GC content and 55 open reading frames, and it is highly homologous to its host. Phylogenetic analysis and average nucleotide sequence identification reveal that vB_HmeY_H4907 is separated from the isolated phages and represents a new family,
Suviridae
, with eight predicted proviruses and six uncultured viral genomes. They are widely distributed in the ocean, suggesting a prevalence of this viral family in the deep sea. These findings expand our understanding of the phylogenetic diversity and genomic features of hadal lysogenic phages, provide essential information for further studies of phage-host interactions and evolution, and may reveal new insights into the lysogenic lifestyles of viruses inhabiting the hadal ocean.

Importance

Halomonas
phage vB_HmeY_H4907 is the deepest isolated siphovirus from the ocean, and it represents a novel abundant viral family in the ocean. This study provides insights into the genomic, phylogenetic, and ecological characteristics of the new viral family, namely,
Suviridae
.
Resolving complex stratigraphic architecture across the Burlington shelf and identifying the Devonian-Carboniferous (Hangenberg) and Kinderhookian-Osagean (Tournaisian) boundary biogeochemical events in the type area of the Mississippian subsystem
Authors: Braun Matthew G. , Bancroft Alyssa M. , Hogancamp Nicholas J. , Stolfus Brittany M. , Heath Megan N. , Clark Ryan J. , Tassier-Surine Stephanie , Day James E. , Cramer Bradley D. 
Published: September 2023

The tristate area of Iowa, Illinois, and Missouri contains some of the best-exposed Mississippian strata in the world, including the type area for the Mississippian subsystem, across a broad carbonate platform known as the Burlington shelf. Strata have been mapped as thinnest along the central middle shelf and thickening both up-ramp and down-ramp, forming a complex dumbbell-like stratigraphic pattern rather than a simple clinoform geometry thinning into the basin. Additionally, two significant hiatuses at the Devonian-Carboniferous boundary and Kinderhookian-Osagean boundary greatly complicate stratigraphic correlations across the region. As a result, the precise temporal relationships between strata deposited across the region remain uncertain.
Two large biogeochemical events occurred during this interval that provide facies-independent chronostratigraphic tools: the Hangenberg event, which marks the Devonian-Carboniferous boundary, and the Kinderhookian-Osagean boundary event. To target these events, we collected 66 conodont samples and 1005 carbonate carbon isotope samples from three cores and three outcrops and integrated the results with existing data from key facies/depth transitions across the Burlington shelf. Our new data demonstrate a complex relationship among complementary stratigraphic thicknesses, where the Devonian-Carboniferous boundary interval is thin or absent in the up-ramp inner-shelf setting and preserved in a significantly expanded interval in the central to distal middle-shelf deposits of southeast Iowa and northeast Missouri. However, the overlying Kinderhookian-Osagean boundary interval is not preserved in this down-ramp setting but is preserved in significantly expanded strata in the up-ramp inner-shelf setting of central Iowa.
Supplemental Material: The volatile record of volcanic apatite and its implications for the formation of porphyry copper deposits
Authors: Stonadge George , al. et 
Published: September 2023

<p>Supplementary material 1 provides detail on modeling, analytical methodologies, and sample locations. Supplementary materials 2 and 3 include the melt models for Mount Pinatubo and Taal volano, respectively. Supplementary material 4 includes SEM-EDS and EPMA data from this study and legacy sources. </p>
Using the multiple streams model to elicit an initial programme theory: from policy dialogues to a roadmap for scaling up integrated care
Authors: Martens Monika , van Olmen Josefien , Wouters Edwin , Boateng Daniel , Van Damme Wim , Van Belle Sara 
Published: September 2023

IntroductionThe ‘SCale-Up diaBetes and hYpertension care’ Project aims to support the scale-up of integrated care for diabetes and hypertension in Cambodia, Slovenia and Belgium through the co-creation, implementation and evaluation of contextualised roadmaps. These roadmaps offer avenues for action and are built on evidence as well as stakeholder engagement in policy dialogues. Roadmaps and policy dialogues are very much intertwined and considered to be key elements for successful stakeholder-supported scale-up in integrated chronic care. Yet, little is known about how, why and under which conditions policy dialogue leads to successful roadmap implementation and scale-up of integrated care. Therefore, this study aims to use a realist approach to elicit an initial programme theory (IPT), using political science theories on the policy process.MethodsTo develop the IPT, information from different sources was collected. First, an exploratory literature review on policy dialogue and scale-up definitions and success factors was performed, identifying theoretical frameworks, empirical (case) studies and realist studies (information gleaning). Second, research workshops on applying theory to the roadmap for scale-up (theory gleaning) were conducted with a multidisciplinary expert team. We used the intervention–context–actors–mechanism–outcome configuration to synthesise information from the sources into a configurational map.ResultsThe information and theory gleaning resulted into an IPT, hypothesising how policy dialogues can contribute to roadmap success in different policy stages. The IPT draws on political science theory of the multiple streams model adapted by Howlettet alto include five streams (problem, solution, politics, process and programme) that can emerge, converge and diverge across all five policy stages.ConclusionThis paper aims to extend the knowledge base on the use of policy dialogues to build a roadmap for scale-up. The IPT describes how (dynamics) and why (theories) co-created roadmaps are expected to work in different policy stages.
Associations between immune-mediated diseases (IMDs) and the risk of HPV-associated diseases: a UK Biobank cohort analysis
Authors: Feng Lan , Qiu Ke , Rao Yufang , Shu Tao , Song Yao , Cheng Danni , Mao Minzi , Li Junhong , Zhang Ziyan , Wang Xiaoyu , Zeng Xinghan , Zhao Yu , Ren JianJun 
Published: September 2023

ObjectivesTo systematically assess the associations between various immune-mediated diseases (IMDs) and human papillomavirus (HPV)-associated diseases.DesignRetrospective cohort study.SettingUK Biobank.ParticipantsA total of 500 371 subjects aged 40–69 years were eligible for the analysis, after excluding those with prevalent HPV-associated diseases at baseline and those who had withdrawn their informed consent or lacked information on sex.ExposureEighty IMDs (involving allergic/atopic diseases, autoimmune diseases, immunodeficiency diseases, etc) were identified in the UK Biobank.Primary and secondary outcome measuresThe main outcome was the incidence of HPV-associated diseases (including warts and malignancies of the cervix, oropharynx, anus, penis, vulva and vagina). Cox proportional hazards model was used to estimate HRs and 95% CIs with particular adjustment for sexual behaviours. We also conducted subgroup analyses based on benign and malignant status, and anatomical sites of HPV-associated diseases, respectively.ResultsDuring a median of 12.0 years of follow-up, 2244 cases out of 500 371 subjects developed HPV-associated diseases. Overall, participants with IMDs had a higher risk of HPV-associated diseases than their controls after adjustment for sexual behaviours and other potential confounders (female: HR=1.90, 95% CI=1.66 to 2.17, p<0.001; male: HR=1.66, 95% CI=1.41 to 1.97, p<0.001). Additionally, eight individual IMDs in women (eg, asthma: HR=1.76, 95% CI=1.47 to 2.11, p<0.001) and three in men (eg, chronic nephritic syndrome: HR=6.05, 95% CI=3.32 to 11.04, p<0.001) were associated with increased risk of HPV-associated diseases. Subgroup analyses revealed significant IMD differences between benign and malignant subgroups as well as between oropharyngeal and anogenital subgroups.ConclusionIn this large retrospective cohort study, IMDs were significantly associated with an elevated risk of HPV-associated diseases. Besides, gender-specific and region-specific associations were also observed between individual IMDs and HPV-associated diseases.
Characterising patterns in routinely reported longitudinal HIV data in South Africa using a Bayesian multiplicative interaction model
Authors: Nonyane Bareng A S , Steiner Laura , Shearer Kate , Genade Leisha , Martinson Neil , Hoffmann Christopher J , Golub Jonathan E , Lebina Limakatso 
Published: September 2023

IntroductionWe consider an analytical problem of characterising patterns and identifying discrepancies between database systems for longitudinal aggregated healthcare data involving multiple facilities.MethodsWe used routinely collected data on the registered number of people living with HIV who initiated antiretroviral treatment (ART) in 69 South African facilities in 2019; reported in the Three Interlinked Electronic register (Tier.net) and the District Health Information System. A Bayesian multiplicative interaction model quantified the average time effect as realised through the heterogeneous facility-specific slopes and quantified discrepancies between the two database sources.ResultsThe estimated average trends showed a slight dip in June and a large dip in December. The estimated slopes identified clusters of facilities based on their ranges of fluctuations over time. The differences in average monthly ART initiations between the two database sources had a median of 1.6 (IQR 0.8–3.3), while 3 outlying facilities differed by at least 10 ART initiations between the 2 sources.ConclusionMultiplicative interaction models are a powerful tool for quantifying average trends over time and for evaluating discrepancies between reporting systems for multiple facilities with heterogeneous time slopes. The Bayesian framework enables efficient estimation for a very large number of parameters.
CCL21-DC in situ vaccination in murine NSCLC overcomes resistance to immunotherapy and generates systemic tumor-specific immunity
Authors: Salehi-Rad Ramin , Lim Raymond J , Du Yushen , Tran Linh M , Li Rui , Ong Stephanie L , Ling Huang Zi , Dumitras Camelia , Zhang Tianhao , Park Stacy J , Crosson William , Kahangi Bitta , Abascal Jensen , Seet Christopher , Oh Michael , Shabihkhani Maryam , Paul Manash , Krysan Kostyantyn , Lisberg Aaron E , Garon Edward B , Liu Bin , Dubinett Steven M 
Published: September 2023

BackgroundDespite recent advances in immunotherapy, many patients with non-small cell lung cancer (NSCLC) do not respond to immune checkpoint inhibitors (ICI). Resistance to ICI may be driven by suboptimal priming of antitumor T lymphocytes due to poor antigen presentation as well as their exclusion and impairment by the immunosuppressive tumor microenvironment (TME). In a recent phase I trial in patients with NSCLC, in situ vaccination (ISV) with dendritic cells engineered to secrete CCL21 (CCL21-DC), a chemokine that facilitates the recruitment of T cells and DC, promoted T lymphocyte tumor infiltration and PD-L1 upregulation.MethodsMurine models of NSCLC with distinct driver mutations (KrasG12D/P53+/-/Lkb1-/-(KPL);KrasG12D/P53+/-(KP); andKrasG12D(K)) and varying tumor mutational burden were used to evaluate the efficacy of combination therapy with CCL21-DC ISV plus ICI. Comprehensive analyses of longitudinal preclinical samples by flow cytometry, single cell RNA-sequencing (scRNA-seq) and whole-exome sequencing were performed to assess mechanisms of combination therapy.ResultsISV with CCL21-DC sensitized immune-resistant murine NSCLCs to ICI and led to the establishment of tumor-specific immune memory. Immunophenotyping revealed that CCL21-DC obliterated tumor-promoting neutrophils, promoted sustained infiltration of CD8 cytolytic and CD4 Th1 lymphocytes and enriched progenitor T cells in the TME. Addition of ICI to CCL21-DC further enhanced the expansion and effector function of T cells both locally and systemically. Longitudinal evaluation of tumor mutation profiles revealed that CCL21-DC plus ICI induced immunoediting of tumor subclones, consistent with the broadening of tumor-specific T cell responses.ConclusionsCCL21-DC ISV synergizes with anti-PD-1 to eradicate murine NSCLC. Our data support the clinical application of CCL21-DC ISV in combination with checkpoint inhibition for patients with NSCLC.
Onyx cast thrombectomy: bailout during thalamic AVM embolization
Authors: Colasurdo Marco , Chen Huanwen , Edhayan Gautam , Shaltoni Hashem , Kan Peter 
Published: September 2023

Microsurgical resection, radiosurgery, and endovascular embolization are the three different treatment approaches to cerebral arteriovenous malformations (AVMs). Although microsurgical resection remains the most desirable curative option and radiosurgery is often first choice in deep located/eloquent unruptured AVMs, transarterial or transvenous embolization may be pursued for ruptured AVMs not amenable to surgical resection. Most complications during endovascular treatment are related to hemorrhage; however, liquid embolic fragment migration or parent vessel occlusion are also possible and can lead to ischemic events. We present a case of endovascular Onyx (Medtronic, Minnesota, USA) embolization of a ruptured thalamic AVM complicated by Onyx reflux into the proximal posterior cerebral artery causing complete vascular occlusion. We demonstrate a bailout technique1–4 using combined stent-retriever and aspiration catheter to dislodge and retrieve the refluxed Onyx cast while maintaining total occlusion of the initially targeted arterial AVM feeder (video 1).Video 1­
Can we use heavy nuclei to detect relic neutrinos?
Authors: Mikulenko Oleksii , Cheipesh Yevheniia , Cheianov Vadim , Boyarsky Alexey 
Published: September 2023

AbstractRecent analysis of the viability of solid state-based relic neutrino detectors has revealed the fundamental necessity for the use of heavy, $$A>100$$

A
>
100

, $$\beta $$
β
-decayers as neutrino targets. Of all heavy isotopes, "Equation missing" and "Equation missing" stand out for their sufficiently low decay energies, reasonable half-life times and stable daughter nuclei. However, the crucial bit of information, that is the soft neutrino capture cross-section is missing for both isotopes. The main reason for that is a particular type of $$\beta $$
β
-decay, which precludes a simple link between the isotope’s half-life time and the neutrino capture rate. In light of the necessity for a reliable estimate of the capture rate – unimpeded by potentially devastating theoretical uncertainties – prior to using the isotope in a full-scale experiment, we propose an experimental method to bypass this difficulty and obtain the capture cross-section of a soft neutrino by a given isotope from the isotope’s $$\beta $$
β
-spectrum.
Chaotic motion of scalar particle coupling to Chern–Simons invariant in the stationary axisymmetric Einstein–Maxwell dilaton black hole spacetime
Authors: Zhang Lina , Chen Songbai , Pan Qiyuan , Jing Jiliang 
Published: September 2023

AbstractWe investigate the motion of a test scalar particle coupling to the Chern–Simons (CS) invariant in the background of a stationary axisymmetric black hole in the Einstein–Maxwell–Dilaton–Axion (EMDA) gravity. Comparing with the case of a Kerr black hole, we observe that the presence of the dilation parameter makes the CS invariant more complex, and changes the range of the coupling parameter and the spin parameter where the chaotic motion appears for the scalar particle. Moreover, we find that the coupling parameter together with the spin parameter also affects the range of the dilation parameter where the chaos occurs. We also probe the effects of the dilation parameter on the chaotic strength of the chaotic orbits for the coupled particle. Our results indicate that the coupling between the CS invariant and the scalar particle yields the richer dynamical behavior of the particle in the rotating EMDA black hole spacetime.