bluuebunny/crossref_metadata_2025_split huggingface dataset:
MAHABBAH DAN MA’RIFAH DALAM TASAWUF DZUNNUN AL-MISHRI
Authors: Wati Mina 
Published: April 2023

This article discusses mahabbah (the love of beings to God) and ma’rifah (the blessing of God to beings) that focuses on the thought of Dzunnun al-Mishri (hereinafter referred to as Dzunnun). The insufficiency of research on mahabbah and ma’rifah is the main reason for the requirement for further research related to the character and the relationship between this two concepts. So far, when talking about mahabbah, the most popular name is Rabiah al-Adawiyah. It is necessary to discuss about mahabbah and ma’rifah in the frame of thought of Dzunnun being resurrected. In addition, in this day and age, it is necessary for humankind to explore the concepts offered by Dzunnun given the many global impediment that cause humanity to drought in spirituality. This article is based on library or library research that examines library data by using descriptive analysis, interpretation and data analysis methods. The source used is secondary data which is used as a support for writing this article. The approach of Sufism with the general method of the Sufis is a prominent feature in the writing of this article. Ma’rifah is the highest level in the application of Sufism that can be achieved with Mahabbah. Every human being can do and feel mahabbah because in essence mahabbah creates servant’s love for the Creator. Meanwhile, ma’rifah is knowing or knowing God so that his heart can see God and he feels close to God. The relationship between the two can be said with the sentence, “love grows because of knowledge and cognition of God.” From that sentence, it can be seen that there is a correlation between mahabbah and ma’rifah. Ma’rifah can be obtained if humans have traced and felt mahabbah. Mahabbah is a feeling of closeness to God through love (spirit). Meanwhile, ma’rifah is the level of knowledge to God through the eyes of the heart (al-Qalb).
PEMIKIRAN TASAWUF FALSAFI AWAL: RABI’AH AL-‘ADAWIYYAH, AL-BUSTAMĪ, DAN AL-HALLAJ
Authors: Sulaeman Mubaidi 
Published: April 2023

Many researchers believe that the philosophical Sufism tradition in Islam only emerged in the sixth century Hijriah. Is that right? If it is explored in more depth, it will soon be found that this is not quite right because long before that, in the Islamic tradition there were already some thoughts of Sufism that tended to lead to philosophical Sufism. Among the philosophical ideas of Sufism that were born in this early period were mahabbah, Ilahiyyah, fana', ittihad, and Hulul. Therefore, in this paper the author tries to describe the initial philosophical Sufism thought contained in the thoughts of three Sufi figures, namely Rabi'ah al-'Adawiyyah, alBustami, and al-Hallaj. By presenting the philosophical Sufism thought that exists in their works, this article shows that the philosophical Sufism tradition in Islam has emerged long before the sixth century Hijriah, as is often believed by many circles.
MAKNA PERNIKAHAN DALAM PERSPEKTIF TASAWUF
Authors: Anisyah Anisyah 
Published: April 2023

This article reviews the view of Sufism on marriage. Marriage is one of the human alternatives to fulfill biological needs and is one of the factors why marriage is highly recommended and celibacy is not recommended. Marriage is also a way for someone to be as close to God as possible. Therefore, it is very relevant if the problem of marriage is seen in the perspective of Sufism and applies the values of Sufism in human life as a provision for someone to build a household ark that is sakinah mawwadah and wa rohmah.
High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity
Authors: Kobi Jéssika Butcovsky Botto Sarter , Matias Amanda Martins , Gasparini Patrícia Vasconcelos Fontana , Torezani‐Sales Suellem , Madureira Amanda Rangel , da Silva Daniel Sesana , Correa Camila Renata , Garcia Jéssica Leite , Haese Douglas , Nogueira Breno Valentim , de Assis Arícia Leone Evangelista Monteiro , Lima‐Leopoldo Ana Paula , Leopoldo André Soares 
Published: April 2023

AbstractThe study examines the influence of three types of hypercaloric diets on metabolic parameters, inflammatory markers, and oxidative stress in experimental model. Male Wistar rats (n = 40) were randomized in control (C), high‐sucrose (HS), high‐fat (HF), and high‐fat with sucrose (HFHS) for 20 weeks. Nutritional, metabolic, hormonal, and biochemical profiles, as well as histological analysis of adipose and hepatic tissues were performed. Inflammation and oxidative stress were determined. HF model caused obesity and comorbidities as glucose intolerance and arterial hypertension. In relation to hormonal and biochemical parameters, there was no significant difference between the groups. All groups showed increased deposition of fat droplets in the hepatic tissue, even though adipocyte areas were similar. Biomarkers of oxidative stress in serum and adipose tissues were similar among the groups. HF model was effective in triggering associated obesity and comorbidities in male rats, but all hypercaloric diets were unable to promote oxidative stress and inflammation.
Studying the nomenclature of dioxins using a structure model kit based on electronic components linked with plastic tubes
Authors: Horikoshi Ryo , Shirotani Dai , Shioyama Hiroshi 
Published: April 2023

Abstract
Commercially available molecular models are elaborately made but generally expensive, which hinders their distribution to all classroom students. Aiming at developing an affordable molecular model, we developed a structure model kit consisting of inexpensive electronic components including transistors and colored light-emitting diodes (LEDs) with a total cost of ca. 2 USD. The structure model kit was designed for building a family of environmental pollutant molecules known as dioxins, in which transistor, white LED, red LED, and yellow LED components are used to represent sp2 carbon, hydrogen, oxygen, and chlorine atoms, respectively. Herein, we report an activity directed to nonchemistry majors studying environmental science and electronic engineering to help them gain insight into the molecular structure of dioxins using the newly developed structure model kit. The activity was well received by many students, some of whom came to understand the relationship between the structure and nomenclature of dioxins, mainly 2,3,7,8-tetrachlorinated dibenzo-p-dioxin (2,3,7,8-TCDD) and its isomers.
On the existence of special nonlinear invariants for round functions of XSL-ciphers
Authors: Burov Dmitriy A. 
Published: April 2023

Abstract
Nonlinear invariants of round transformations in XSL-schemes are studied. The emphasis is on invariants which may be found by means of the approach suggested at the conference ASIACRYPT 2016. Some known results on the inertia groups of decomposable functions are used to describe conditions on S-boxes and matrices of XSL-schemes which are necessary for the existence of such invariants. It is shown that for a number of schemes these conditions are not satisfied.
Asymptotic local probabilities of large deviations for branching process in random environment with geometric distribution of descendants
Authors: Denisov Konstantin Yu. 
Published: April 2023

Abstract
We consider the branching process

Z

n

=

X

n
,
1

+
⋯
+

X

n

Z

n
−
1

$ Z_{n} =X_{n, 1} + \dotsb +X_{nZ_{n-1}} $

, in random environments
η
, where
η
is a sequence of independent identically distributedvariables, for fixed
η
the random variables X

i, j
areindependent, have the geometric distribution. We suppose that the associated random walk

S
n

=

ξ
1

+
⋯
+

ξ
n

$ S_n = \xi_1 + \dotsb + \xi_n $

has positive meanμ,0 < h<h
+satisfies the right-hand Cramer’s condition
E
exp(h
ξ

i
) < ∞ for, some h
+. Under theseassumptions, we find the asymptotic representation for local probabilities
P
(Z

n
=⌊exp(θ n)⌋) for θ ∈ [θ
1, θ
2]⊂</given−names><x> </x><surname>(μ;μ
+) and someμ
+.
Towards a better similarity algorithm for host-based intrusion detection system
Authors: Ouarda Lounis , Malika Bourenane , Brahim Bouderah 
Published: April 2023

Abstract
An intrusion detection system plays an essential role in system security by discovering and preventing malicious activities. Over the past few years, several research projects on host-based intrusion detection systems (HIDSs) have been carried out utilizing the Australian Defense Force Academy Linux Dataset (ADFA-LD). These HIDS have also been subjected to various algorithm analyses to enhance their detection capability for high accuracy and low false alarms. However, less attention is paid to the actual implementation of real-time HIDS. Our principal objective in this study is to create a performant real-time HIDS. We propose a new model, “Better Similarity Algorithm for Host-based Intrusion Detection System” (BSA-HIDS), using the same dataset ADFA-LD. The proposed model uses three classifications to represent the attack folder according to certain criteria, the entire system call sequence is used. Furthermore, this work uses textual distance and compares five algorithms like Levenshtein, Jaro–Winkler, Jaccard, Hamming, and Dice coefficient, to classify the system call trace as attack or non-attack based on the notions of interclass decoupling and intra-class coupling. The model can detect zero-day attacks because of the threshold definition. The experimental results show a good detection performance in real-time for Levenshtein/Jaro–Winkler algorithms, 99–94% in detection rate, 2–5% in false alarm rate, and 3,300–720 s in running time, respectively.
Dimensions of artificial intelligence techniques, blockchain, and cyber security in the Internet of medical things: Opportunities, challenges, and future directions
Authors: Ameen Aya Hamid , Mohammed Mazin Abed , Rashid Ahmed Noori 
Published: April 2023

Abstract
The Internet of medical things (IoMT) is a modern technology that is increasingly being used to provide good healthcare services. As IoMT devices are vulnerable to cyberattacks, healthcare centers and patients face privacy and security challenges. A safe IoMT environment has been used by combining blockchain (BC) technology with artificial intelligence (AI). However, the services of the systems are costly and suffer from security and privacy problems. This study aims to summarize previous research in the IoMT and discusses the roles of AI, BC, and cybersecurity in the IoMT, as well as the problems, opportunities, and directions of research in this field based on a comprehensive literature review. This review describes the integration schemes of AI, BC, and cybersecurity technologies, which can support the development of new systems based on a decentralized approach, especially in healthcare applications. This study also identifies the strengths and weaknesses of these technologies, as well as the datasets they use.
Reflections on the Preservation of Tunisian Cultural Heritage in a Post-crisis Context: Between Digitalization and Innovative Promotional Techniques
Authors: Ben Yahia Karim , Bouslama Fedia 
Published: April 2023

Abstract
The revival of the value of cultural heritage is imperative for the conservation of this asset. An anchoring between past and present is essential for any nation concerned with preserving this rich heritage, and protecting it from deperdition. A new conceptualization of the preservation of Tunisian cultural heritage in a post-crisis context integrates the role of the state as well as the private sector/NGOs and international institutions to conserve and subsequently promote this heritage. This approach tends to revive certain components of cultural heritage and to revitalize the economic sphere that revolves around it. This research focuses on the integration of digitalization and innovative techniques in order to preserve or even promote Tunisia’s cultural heritage. Qualitative research, through the combination of in-depth interviews and focus groups, was carried out with the governmental sector, private/NGOs, and foreign institutions whose aim is to promote this heritage. The combination of the results of these sectors tends to provide a pragmatic picture of the current post-crisis situation in addition to important managerial contributions. An analysis of the qualitative corpus via T-LAB Plus 2022 made it possible to identify the technologies most mentioned by the respondents.
A review on the efficacy and safety of lipid-lowering drugs in neurodegenerative disease
Authors: Rajabian Arezoo , McCloskey Alice P. , Jamialahmadi Tannaz , Moallem Seyed Adel , Sahebkar Amirhossein 
Published: April 2023

Abstract
There is a train of thought that lipid therapies may delay or limit the impact of neuronal loss and poor patient outcomes of neurodegenerative diseases (NDDs). A variety of medicines including lipid lowering modifiers (LLMs) are prescribed in NDDs. This paper summarizes the findings of clinical and observational trials including systematic reviews and meta-analyses relating to LLM use in NDDs published in the last 15 years thus providing an up-to-date evidence pool. Three databases were searched PubMed, CINAHL, and Web of Science using key terms relating to the review question. The findings confirm the benefit of LLMs in hyperlipidemic patients with or without cardiovascular risk factors due to their pleotropic effects. In NDDs LLMs are proposed to delay disease onset and slow the rate of progression. Clinical observations show that LLMs protect neurons from α-synuclein, tau, and Aβ toxicity, activation of inflammatory processes, and ultimately oxidative injury. Moreover, current meta-analyses and clinical trials indicated low rates of adverse events with LLMs when used as monotherapy. LLMs appear to have favorable safety and tolerability profiles with few patients stopping treatment due to severe adverse effects. Our collated evidence thus concludes that LLMs have a role in NDDs but further work is needed to understand the exact mechanism of action and reach more robust conclusions on where and when it is appropriate to use LLMs in NDDs in the clinic.
Competition for Quality of Services under Net Neutrality and Prioritization
Authors: Kim Jeong-Yoo 
Published: April 2023

Abstract
This paper examines the effect of prioritization on competing CPs’ incentives to invest to improve their quality of service (QoS). We show that in the single-homing case, no CP makes a positive amount of investment under net neutrality because the effect of reducing delay is shared by both CPs, while the prioritized CP does not invest to improve QoS in the M/M/1 queuing model in which the effect is shared by the unprioritized CP and both CPs invest for QoS in the bandwidth subdivision model in which the effect is not shared. In the multi-homing case, however, CPs invest for QoS even under net neutrality, because CPs do not virtually compete against each other.
Cellular Diversity in Human Subgenual Anterior Cingulate and Dorsolateral Prefrontal Cortex by Single-Nucleus RNA-Sequencing
Authors: Kim Billy , Kim Dowon , Schulmann Anton , Patel Yash , Caban-Rivera Carolina , Kim Paul , Jambhale Ananya , Johnson Kory R. , Feng Ningping , Xu Qing , Kang Sun Jung , Mandal Ajeet , Kelly Michael , Akula Nirmala , McMahon Francis J. , Lipska Barbara , Marenco Stefano , Auluck Pavan K. 
Published: April 2023

Regional cellular heterogeneity is a fundamental feature of the human neocortex; however, details of this heterogeneity are still undefined. We used single-nucleus RNA-sequencing to examine cell-specific transcriptional features in the dorsolateral PFC (DLPFC) and the subgenual anterior cingulate cortex (sgACC), regions implicated in major psychiatric disorders. Droplet-based nuclei-capture and library preparation were performed on replicate samples from 8 male donors without history of psychiatric or neurologic disorder. Unsupervised clustering identified major neural cell classes. Subsequent iterative clustering of neurons further revealed 20 excitatory and 22 inhibitory subclasses. Inhibitory cells were consistently more abundant in the sgACC and excitatory neuron subclusters exhibited considerable variability across brain regions. Excitatory cell subclasses also exhibited greater within-class transcriptional differences between the two regions. We used these molecular definitions to determine which cell classes might be enriched in loci carrying a genetic signal in genome-wide association studies or for differentially expressed genes in mental illness. We found that the heritable signals of psychiatric disorders were enriched in neurons and that, while the gene expression changes detected in bulk-RNA-sequencing studies were dominated by glial cells, some alterations could be identified in specific classes of excitatory and inhibitory neurons. Intriguingly, only two excitatory cell classes exhibited concomitant region-specific enrichment for both genome-wide association study loci and transcriptional dysregulation. In sum, by detailing the molecular and cellular diversity of the DLPFC and sgACC, we were able to generate hypotheses on regional and cell-specific dysfunctions that may contribute to the development of mental illness.SIGNIFICANCE STATEMENTDysfunction of the subgenual anterior cingulate cortex has been implicated in mood disorders, particularly major depressive disorder, and the dorsolateral PFC, a subsection of the PFC involved in executive functioning, has been implicated in schizophrenia. Understanding the cellular composition of these regions is critical to elucidating the neurobiology underlying psychiatric and neurologic disorders. We studied cell type diversity of the subgenual anterior cingulate cortex and dorsolateral PFC of humans with no neuropsychiatric illness using a clustering analysis of single-nuclei RNA-sequencing data. Defining the transcriptomic profile of cellular subpopulations in these cortical regions is a first step to demystifying the cellular and molecular pathways involved in psychiatric disorders.
CSMD3Deficiency Leads to Motor Impairments and Autism-Like Behaviors via Dysfunction of Cerebellar Purkinje Cells in Mice
Authors: Xi Ke , Cai Si-Qing , Yan Hui-Fang , Tian Yue , Cai Jie , Yang Xiao-Mei , Wang Jing-Min , Xing Guo-Gang 
Published: April 2023

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with highly heritable heterogeneity. Mutations of CUB and sushi multiple domains 3 (CSMD3) gene have been reported in individuals with ASD. However, the underlying mechanisms of CSMD3 for the onset of ASD remain unexplored. Here, using maleCSMD3knock-out (CSMD3−/−) mice, we found that genetic deletion ofCSMD3produced core autistic-like symptoms (social interaction deficits, restricted interests, and repetitive and stereotyped behaviors) and motor dysfunction in mice, indicating that theCSMD3gene can be considered as a candidate for ASD. Moreover, we discovered that the ablation ofCSMD3in mice led to abnormal cerebellar Purkinje cell (PC) morphology in Crus I/II lobules, including aberrant developmental dendritogenesis and spinogenesis of PCs. Furthermore, combiningin vivofiber photometry calcium imaging andex vivoelectrophysiological recordings, we showed that theCSMD3−/−mice exhibited an increased neuronal activity (calcium fluorescence signals) in PCs of Crus I/II lobules in response to movement activity, as well as an enhanced intrinsic excitability of PCs and an increase of excitatory rather than inhibitory synaptic input to the PCs, and an impaired long-term depression at the parallel fiber–PC synapse. These results suggest that CSMD3 plays an important role in the development of cerebellar PCs. Loss of CSMD3 causes abnormal PC morphology and dysfunction in the cerebellum, which may underlie the pathogenesis of motor deficits and core autistic-like symptoms inCSMD3−/−mice. Our findings provide novel insight into the pathophysiological mechanisms by whichCSMD3mutations cause impairments in cerebellar function that may contribute to ASD.SIGNIFICANCE STATEMENTAutism spectrum disorder (ASD) is a neurodevelopmental disorder with highly heritable heterogeneity. Advances in genomic analysis have contributed to numerous candidate genes for the risk of ASD. Recently, a novel giant geneCSMD3encoding a protein with CUB and sushi multiple domains (CSMDs) has been identified as a candidate gene for ASD. However, the underlying mechanisms ofCSMD3for the onset of ASD remain largely unknown. Here, we unravel that loss ofCSMD3results in abnormal morphology, increased intrinsic excitabilities, and impaired synaptic plasticity in cerebellar PCs, subsequently leading to motor deficits and ASD-like behaviors in mice. These results provide novel insight into the pathophysiological mechanisms by whichCSMD3mutations cause impairments in cerebellar function that may contribute to ASD.
Using Seawater Reverse Osmosis (SWRO) Technology in Seawater Desalination Processes
Authors: Hapsari Larasati Putri , Pranoto Aris Kabul , Rinjani Widi Ayu , Anasri Anasri , Anjani Ika , Rahman Abdul 
Published: April 2023

Water is one of the basic needs for human life, including for people living on the coast. It is difficult to get clean water for consumption because most coastal areas are affected by sea conditions that have high salinity. In order to be consumed, the saline water must be desalinated. Desalination is a process to convert saline water into fresh water. One such desalination technology is using reverse osmosis (RO). The purpose of this study was to determine the process of desalination of seawater into freshwater using the seawater reverse osmosis (SWRO) method. The method used in this research is observation, which is to see directly the stages of the desalination process of seawater into fresh water. The data was obtained in the form of primary data from observations and secondary data from the literature to support primary data. Analysis of the data used in the form of descriptive analysis by describing each stage carried out in the SWRO process. The results showed that the seawater desalination process using SWRO technology had 14 stages. These stages include; intake, raw water pump, raw water reservoir, UF feed pump, Automatic screen, ultrafiltration, UF water reservoir, RO feed pump, HPP & booster, RO membrane, RO water reservoir, permeate pump, chlorine analyzer, product water. In developed and developing countries, SWRO units have been widely used, because by processing seawater into freshwater, there are many benefits for the life cycle and it is environmentally friendly. It also maintains underground fresh water so that it can provide plant life, and trees that provide us with clean oxygen for our lives.