bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Dietary Supplementation of Red and Larch Pine Needle Powders on Productivity, Egg Quality, Yolk Fatty Acids and Cholesterol and Hatchability of Laying Quails
Authors: Atalay Ali Ihsan , Tosun Ramazan , Saftan Metin 
Published: January 2025

ABSTRACTThis study aimed to determine the efficacy of red pine and larch pine needles powder at different doses on productive performance, egg quality, hatching parameters, total fatty acid and cholesterol levels of laying quails. A total of 126 (84 ♀ and 42 ♂) 20‐week‐old laying quail were randomly distributed into seven experimental diets with three replicates of six (four female and two male) birds per cage. The groups were fed a basal diet (CON group), a basal diet with red pine needle powder (RPNP group) (1.5%, 3% and 4.5%), or a basal diet with larch pine needle powder (LPNP group) (1.5%, 3% and 4.5%) for 9 weeks. The results showed that the additives which were added into the ration did not affect feed intake and feed conversion ratio among the performance parameters compared to the control group (p > 0.05). Egg production increased by 13%–14% in RPNP 1.5% and LPNP 4.5% groups compared to the control group (p < 0.05). Egg weight increased by 4.04% only at the RPNP 4.5% dose (p < 0.05). However, egg weight decreased by 3.68%, 2.88% and 5.75% in RPNP 3% and LPNP 3% and 4.5% doses, respectively (p < 0.05). The highest increase in egg mass compared to the control was 13.61% in the RPNP 1.5% dose (p < 0.05). Egg shape index increased by 8.18% in the RPNP 1.5% group and 11.11% in the LPNP 3% group (p < 0.05). Haugh units increased by 1.87% and 1.77% in RPNP 1.5% and LPNP 4.5% doses, respectively (p < 0.05). The amount of broken eggs increased in the LPNP 1.5% (2.86%) and LPNP 3% (3.65%) doses relative to the control group (0.40%) (p < 0.05). Egg yolk decreased by 7.2%–17.6% in RPNP 1.5% and 3% groups and LPNP 3% and 4.5% doses (p < 0.05). Egg yolk diameter decreased by 3.21%–6.56% in RPNP 1.5% and 3% groups and LPNP 4.5% doses (p < 0.05). Yolk index decreased by an average of 5.5%–7% in RPNP 1.5% and 4.5% doses and LPNP 4.5% doses (p < 0.05). Pine needle supplementation increased total monounsaturated fatty acids in egg yolks by 6% compared to the control group, while cholesterol levels decreased by 7.73% compared to the control (p < 0.05). On the other hand, pine needle addition had no effect on incubation parameters (p > 0.05). Our results clearly indicated that the 1.5% red pine needles powder could be used as an additive to increase the egg production, egg mass and Haugh units in laying quails.
Pseudohaematuria Due to Mesalazine: A Case Report
Authors: Truong Mimi , Kairaitis Lukas , Castelino Ronald L. 
Published: January 2025

ABSTRACTThe symptom of macroscopic or ‘visible’ haematuria can cause significant patient distress, largely due to its' potential association with urinary tract malignancy, infection or glomerular disease. This lesson from practice describes the case of a 19‐year‐old female patient for whom the cause of red/brown urinary discolouration was found to relate to a reaction between renally excreted mesalazine and domestic bleach in the toilet bowel. Recognition of this phenomenon in patients taking mesalazine for inflammatory colitis is important to minimise patient distress and unnecessary investigation for a urinary tract cause.
Development of a machine learning predictive model for central venous catheter‐associated thrombosis in patients undergoing abdominal surgery
Authors: Li Zirong , Zhang Cheng , Gan Xiao , Liu Liying , Tan Yanmei , Ying Yanping 
Published: January 2025

AbstractBackgroundCentral venous catheters (CVCs) are placed where the vena cava meets the right atrium. Their common use raises the risk of catheter‐related thrombosis (CRT), a potentially life‐threatening complication.AimThis study leverages machine learning to develop a CRT predictive model for abdominal surgery patients, aiming to refine clinical decisions and elevate treatment quality.Study DesignThe data were split into training and validation sets using the caret package in R. Decision Trees (DT), Extra Trees (ET), Ada Boost, Gradient Boosting (GB), Light Gradient Boosting Machine (LGBM), K Neighbours Classifier (KNN) and Random Forest (RF) algorithms were used for model construction. Receiver operating characteristic (ROC) curve, area under curve (AUC), accuracy, recall, precision, F1 score, sensitivity and specificity were used to evaluate the performance of the model. Decision curve analysis (DCA) was used to evaluate the clinical utility of each model.ResultsAmong the 400 subjects, 184 had thrombosis, with an incidence of 46%. Basic characteristics analysis and univariate analysis showed that there were significant differences in the history of radiotherapy or chemotherapy, age, mobility score, retention time, D‐dimer, fibrinogen and urea (p < .05). Among the models constructed by the seven algorithms, the performance of DT model was relatively balanced. The AUC of the validation set was 0.782, the sensitivity was 0.618, and the specificity was 0.781.ConclusionThe predictive model for CRT developed using machine learning algorithms demonstrates good discrimination and clinical applicability among abdominal surgery patients, offering valuable guidance for CRT prevention strategies.Relevance to Clinical PracticeBy integrating risk prediction models into the Hospital Information System (HIS), nurses can assess catheter status in a timely and accurate manner, understand the risks of thrombosis for patients, and implement targeted preventive measures. This approach can enhance the efficiency and accuracy of nursing care, holding clinical significance in critical care practice.
Cell size has pervasive effects on the functional composition and morphology of leaves: a case study in Rhododendron (Ericaceae)
Authors: Dastpak Arezoo , Williams Monica , Perkins Sally , Perkins John A. , Horn Charles , Thompson Patrick , Ryan Connor , Medeiros Juliana , An Yi‐Dong , Jiang Guo‐Feng , Simonin Kevin A. , Roddy Adam B. 
Published: January 2025

AbstractThe leaf economics spectrum (LES) characterizes a tradeoff between building a leaf for durability versus for energy capture and gas exchange, with allocation to leaf dry mass per projected surface area (LMA) being a key trait underlying this tradeoff. However, regardless of the biomass supporting the leaf, high rates of gas exchange are typically accomplished by small, densely packed stomata on the leaf surface, which is enabled by smaller genome sizes. Here, we investigate how variation in genome size‐cell size allometry interacts with variation in biomass allocation (i.e. LMA) to influence the maximum surface conductance to CO2 and the rate of resource turnover as measured by leaf water residence time. We sampled both evergreen and deciduous Rhododendron (Ericaceae) taxa from wild populations and botanical gardens, including naturally occurring putative hybrids and artificially generated hybrids. We measured genome size, anatomical traits related to cell sizes, and morphological traits related to water content and dry mass allocation. Consistent with the LES, higher LMA was associated with slower water residence times, and LMA was strongly associated with leaf thickness. Although anatomical and morphological traits varied orthogonally to each other, cell size had a pervasive impact on leaf functional anatomy: for a given leaf thickness, reducing cell size elevated the leaf surface conductance and shortened the mean water residence time. These analyses clarify how anatomical traits related to genome size‐cell size allometry can influence leaf function independently of morphological traits related to leaf longevity and durability.
Oil Viscosity Effects on Lithium 12-Hydroxystearate Grease Modulus and Thixotropy
Authors: Bonta Jacob , Pham Jonathan T. 
Published: January 2025

Abstract
The effect of base oil viscosity and temperature on the thixotropic recovery of lubricating grease (LG) is investigated via shear rheology. The viscosity of the base lubricant phase of LGs impacts the storage modulus in both the undisturbed and post-sheared states. In this study, we focus on three greases with varied base oil viscosity but similar chemistry: polyalphaolefin (PAO) 8, PAO 40, and PAO 100. Small amplitude oscillatory shear testing is first used to evaluate the viscoelastic modulus in the undisturbed state at varied temperatures. A one-hour full rotation shear is then applied to mechanically disrupt the LGs. The storage modulus is then tracked over time under varied temperatures to investigate thixotropic recovery. These results show that the physical properties of the fluid phase of LGs can significantly impact the mechanical properties of the solid phase present in LGs and that the storage moduli is a function of the state related to temperature.
Optimizing the Concentration Ratio of Multi-Faceted Focusing Heliostats
Authors: Hénault François , Flamant Gilles , Caliot Cyril 
Published: January 2025

Abstract
This paper aims to optimize the concentration ratio of multi-faceted focusing heliostats implemented into a solar tower power plant. The ideal shape of a heliostat located off-axis in the field is known to be the local section of a fictitious paraboloïd whose parameters vary continuously with the sun’s angular position. We describe an optimization procedure applicable to those heliostats. The flux densities formed at the solar receiver and the achievable concentrating ratios are computed using an improved convolution algorithm. It is shown that the optimized heliostat shape can produce typical concentration gains of approximately 10%, even when the heliostats reflect the sun under large incidence angles.
mpactR: an R adaptation of the metabolomics peak analysis computational tool (MPACT) for use in reproducible data analysis pipelines
Authors: Mason Allison R. , Johnson, Jr Gregory , Krampen Joseph , Nguyen Jennifer N. T. , Balunas Marcy J. , Schloss Patrick D. 
Published: January 2025

ABSTRACT

mpactR automates pre-processing of liquid chromatography-tandem mass spectrometry (LC-MS/MS) data from microbiological samples to correct mispicked peaks, resolve inter-sample variation in abundance across technical replicates, account for in-source ion fragmentation, and remove background noise to yield high-quality mass spectrometry features. The package is available through CRAN and GitHub.
Complete chloroplast genome of the marine eelgrass
Zostera pacifica
(Zosteraceae, Plantae) from Monterey, California
Authors: Abdulrahman Sosan , Aguirre Adilene , Arriaga Eliana , Avina Ashley C. , Badajos Angeles , Badillo Yureni A. , Bañuelos Alexis M. , Pulido Javier , Bucio Valdovinos Bet-sua , Champaco Taliyah , Chavez Rodrigo , Chavez-Felix Gregorio , Cruz Melaina , Distancia Melissa , Dzubay Kingsley , Espinoza Andres , Estrada Julie , Fernandez Danneli , Gutierrez-Villanueva Alejandra , Guzman Marc , Hernandez-Tejeda Jimena , Hernandez Victor , Hughey Jeffery R. , Jalomo Sebastian , Khanaka Hanna , Kuepfer Juliah , Laurel Alyssa M. , Lewis Julia , Lopez Hanah E. , Martinez Ana , Martinez Michell J. , Medina Ramirez Jorge A. , Ramirez Cesar M. , Mendez Fatima , Mendoza-Torralba Ashley , Naidu Kajal , Nolasco Abraham , Nuñez Lupita , Paredes Vivian , Anaya Jesse P. , Rajesh Sreenivas , Ramirez Kevin , Salazar Andrea , Sevilla Jeriel S. , Tijero Jennifer G. , Tinoco Viorato Aaron , Valdez Heaven ,   on behalf of Hartnell College Genomics Group
Published: January 2025

ABSTRACT

We present the complete chloroplast genome of the eelgrass
Zostera pacifica
from Monterey, California. The genome is circular and 144,675  bp in length. It consists of 82 protein-coding, 31 transfer RNA, and 8 ribosomal RNA genes and is 99.44%–99.42% similar in nucleotide pairwise identity to the closely related species
Zostera marina
.
Detrital zircon geochronology of a fossiliferous Miocene paleochannel
Authors: Hodges Montana , Newby Tahlor , Swarner Holli , Busby Cathy , Shapiro Russell , Francek Greg , Hodges Christopher 
Published: January 2025

ABSTRACT
A plethora of fauna and flora of uncertain age was recently discovered in fluvial sedimentary rocks of the Mokelumne River drainage of the western Sierra Nevada foothills (California, USA). These fossils are preserved in the Mokelumne paleochannel and show great biodiversity containing mastodon, gomphothere, camel, rhino, horse, dog, rodent, mustelid, tapir, peccary, tortoise, turtle, fish, bird, and abundant tree fossils. Prior to this study, biochronology loosely constrained the age of the fossils to 15–5 Ma and the stratigraphy to either the Valley Springs Formation or Mehrten Formation. This project sampled a fossiliferous stratigraphic section for detrital zircons and used U­Pb laser ablation–inductively coupled plasma–mass spectrometry isotopic dating to establish the most probable age of the fossils at 8.2 ± 0.1 Ma (late Miocene). This age is consistent with U­Pb detrital zircon ages on samples taken from below and above the fossils, which bracket the depositional age of the fossils to younger than 8.23 ± 0.08 Ma and older than 7.24 ± 0.07 Ma, respectively. The detrital zircons were likely sourced from contemporaneous Ancestral Cascades arc volcanism that occurred up­paleochannel, near the present-day Sierra Nevada range crest.
Multiplex lateral flow test sensitivity and specificity in detecting influenza A, B and SARS-CoV-2 in adult patients in a UK emergency department
Authors: Batra Rahul , Blandford Edward , Kulasegaran-Shylini Raghavendran , Futschik Matthias E , Bown Abbie , Catton Matthew , Conti-Frith Hermione , Alexandridou Alexandra , Gill Rebecca , Milroy Clara , Harper Sean , Gettings Holly , Noronha Maryann , Harrison Hooi-Ling , Douthwaite Sam , Nebbia Gaia , Klapper Paul E , Tunkel Sarah , Vipond Richard , Hopkins Susan , Fowler Tom 
Published: January 2025

BackgroundRapid identification of individuals with acute respiratory infections is crucial for preventing nosocomial infections. For rapid diagnosis, especially in EDs, lateral flow devices (LFDs) are a convenient, inexpensive option with a rapid turnaround. Several ‘multiplex’ LFDs (M-LFDs) now exist, testing for multiple pathogens from a single swab sample. We evaluated the real-world performance of M-LFD versus PCR testing in detecting influenza A, B and SARS-CoV-2) in the ED setting.MethodsAfter preliminary evaluation of an M-LFD (SureScreen) with laboratory-grown virus and PCR-negative clinical samples, it was evaluated in a real-world setting at the ED of St Thomas’ Hospital (London, UK) from 1 December 2022 to 21 April 2023. Eligible participants were ≥18 years of age, admitted with respiratory symptoms and received concurrent M-LFD and PCR tests. Main endpoints were sensitivity to detect influenza A/B (primary) and SARS-CoV-2 (secondary) versus PCR. The probability of a true positive in relation to viral concentration (expressed as PCR cycle threshold (Ct)) was analysed using logistic regression.ResultsIn total, 808 symptomatic participants were included (49.8% female; mean age 46.9 years). Test sensitivity (95% CI) was 67.0% (56.9% to 76.1%) for influenza A (n=100), 94.1% (71.3% to 99.9%) for influenza B (n=17) and 48.2% (39.7% to 56.8%) for SARS-CoV-2 (n=141). Sensitivity for SARS-CoV-2 was significantly lower than that for influenza A and B (p=0.0057 and p=0.00088, respectively). The probability of a true positive was 98% for Ct<25 for influenza A and SARS-CoV-2 (influenza B non-evaluable). No co-infections were identified by PCR or M-LFD.ConclusionThe real-world performance of SureScreen M-LFD was consistent with laboratory evaluation and achieved a high sensitivity for individuals with high viral concentration, most likely to be infectious. Given the representative UK population sample, results could be generalised for use in other settings.
Malnutrition risk and overall survival at solid tumour diagnosis
Authors: McFarlane Tori L. , Symanowski James T , Walsh Declan , Aung Ye Myint , Aktas Aynur , Szafranski Michele L , Salo Jonathan C , Meadors Patrick L , Kadakia Kunal C. 
Published: January 2025

PurposeMalnutrition severely impacts tolerance to anticancer therapies, but any relationship with overall survival (OS) at the time of solid tumour diagnosis in outpatients in the USA remains unclear.MethodsThis retrospective study evaluated 3562 patients who completed the Malnutrition Screening Tool (MST) at diagnosis, identifying the relationship between MST risk, a validated tool evaluating anorexia and weight loss, and OS. MST score of ≥2 of 5 was classified as high malnutrition risk (H-MST). Kaplan-Meier techniques and Cox proportional hazards models were used to analyse OS in H-MST versus low malnutrition risk (L-MST).ResultsIn the unadjusted models, MST risk was individually associated with OS. Multivariable regression confirmed that MST risk remained independently prognostic for OS after controlling for key confounding variables, HR=1.51 (95% CI: 1.33 to 1.72). The H-MST group had shorter OS (50-month survival rates: 69% L-MST vs 60% H-MST).ConclusionMST risk at diagnosis is an independent prognostic factor for OS. H-MST risk is associated with shorter survival in a broad cohort of solid tumour oncology outpatients.
Monte Carlo simulation of polymer phantoms in proton therapy for eye tumor treatment
Authors: Aşlar Engin , Ekinci Fatih 
Published: January 2025

Abstract
Traditional methods for treating eye tumors, such as surgery and radiation therapy, can cause damage to surrounding healthy tissues and unwanted side effects. In recent years, proton therapy has emerged as a significant alternative for the treatment of eye tumors. Proton therapy targets cancer cells using proton particles while minimizing damage to the surrounding healthy tissues. Unlike other radiation therapy techniques, proton therapy uses the Bragg peak, which allows protons to concentrate on a specific depth within the tissue. Proton therapy can deliver a high dose of radiation to the tumor area while protecting nearby healthy tissues. Additionally, proton therapy has a more favorable side effect profile than other treatment methods. This study focuses on simulations conducted on eyes and eye phantoms to examine the effects of proton therapy on eye tissues. The simulations analyzed physical effects such as ionization, recoils, and lateral straggle of proton beams using Bragg curves, recoil analyses, and atomic-level interactions. Results indicate that as the energy levels of proton beams increase, the range and energy transfer in eye tissues also increase. These findings emphasize the potential effectiveness of proton therapy for treating eye tumors. Polymer eye phantoms can serve as reliable tools in proton therapy simulations to optimize treatment planning. This study highlights the importance of proton therapy simulations and demonstrates the successful use of various polymer materials. Future studies may also examine the effects of heavy particles in addition to different polymer materials to comprehensively evaluate the impact of proton beams in biomedical applications.
Effect of Ripasudil on the Change Rates of the Circumpapillary Retinal Nerve Fiber Layer Thickness in Patients With Primary Open‐Angle Glaucoma
Authors: Sakurai Katsumasa , Suda Kenji , Akagi Tadamichi , Ikeda Hanako Ohashi , Kameda Takanori , Miyake Masahiro , Hasegawa Tomoko , Tsujikawa Akitaka 
Published: January 2025

Purpose: The effect of the Rho‐kinase inhibitor ripasudil on the retinal optic nerve fiber layer (RNFL) remains unclear. We aimed to determine this effect in patients with primary open‐angle glaucoma (POAG) using optical coherence tomography (OCT) measurements and linear mixed analysis.Methods: This study prospectively included outpatients from a single center with POAG without a history of vitreoretinal or glaucoma surgery from December 2014 to June 2020, in whom the circumpapillary RNFL thickness (cpRNFLT) was measured more than three times before and after ripasudil initiation, without additional medication or surgery during the period. Measurements were performed using OCT in the follow‐up mode. The cpRNFLT change rates were compared before and after treatment using linear mixed models with adjustments for intraocular pressure (IOP) changes.Results: Thirty eyes of 20 patients (12 males and eight females) were included. Upon ripasudil prescription, the average cpRNFLT was 60.2 ± 2.1 μm. The average IOP was 15.1 ± 0.5 and 13.5 ± 0.5 mmHg, respectively, before and after treatment initiation, with a difference of −1.6 ± 0.3 mmHg. Analysis of 343 cpRNFLT measurements using linear mixed models revealed that the cpRNFLT change rate was −0.91 ± 0.15 and −0.40 ± 0.14 μm/year, respectively, before and after treatment onset, with an increase of 0.51 ± 0.21 μm/year. After adjusting for IOP changes, the improvement in cpRNFLT change rate was 0.33 ± 0.23 μm/year, albeit not statistically significant.Conclusion: The cpRNFLT change rate significantly increased after ripasudil administration, whereas the contribution of the IOP decline was not significant.
Abstract 004: Early Feasibility Study of RapidPulse® Aspiration System as Frontline Approach for Patients with Acute Ischemic Stroke due to Large Vessel Occlusions (Pulse‐C Study)
Authors: Nogueira R. , Geyik S. , Bajrami A. , Ribo M. , Mernes R. 
Published: January 2025

Background and aims
The first‐pass effect (FPE) is associated with improved clinical outcomes in mechanical thrombectomy (MT) for large vessel occlusion strokes (LVOS). However, current devices achieve FPE in only 30‐40% of patients. The RapidPulse® Aspiration System (RP) is designed to remove occlusive thrombus from the cerebral vasculature using precisely pulsed aspiration. The system aims to improve revascularization results during aspiration thrombectomy in patients with acute ischemic stroke. Initial clinical evaluation suggests that RapidPulse® can achieve FPE rates in the 70% range. Our goal is to evaluate this technology as a frontline approach in LVOS.

Methods
Prospective, multicenter, open‐label, early experience study of the RapidPulse® System. Patients with LVOS involving anterior and/or posterior circulations within 24 hours from stroke onset, without evidence of intracranial atherosclerotic disease and/or tandem occlusions, and amenable to treatment with the RapidPulse 071 aspiration catheter were eligible. The primary outcome was the rate of FPE (mTICI ≥2c after one pass). Secondary outcomes included frontline technical success (mTICI ≥2b after final pass with no rescue therapy), and incidence of vessel injury and/or device related SAEs. The study will enroll up to 50 participants at up to 5 centers in Europe and Latin America.

Results
As of August 2024, ten patients have been recruited and enrollment is expected to be completed in November 2024. The results of the study will be presented at the SVIN conference.

Conclusions
The RapidPulse® system is a novel cyclic aspiration technology designed to achieve faster and better reperfusion in LVOS while significantly improving FPE and frontline success rates which, in turn, may improve clinical outcomes and reduce overall procedure costs. Additional larger studies are underway.