bluuebunny/crossref_metadata_2025_split huggingface dataset:
New fly records of potential biological control importance in Saudi Arabia (order Diptera)
Authors: El-Hawagry Magdi , Soliman Ahmed M. , Abdel-Dayem Mahmoud S. , Al Dhafer Hathal M. 
Published: August 2023

Abstract
Background
The Ministry of Environment, Water and Agriculture in Saudi Arabia has begun funding some projects to set up some agricultural pest control programs. Therefore, it is very important to enumerate all the predacious or parasitic insects that live on or in other agricultural insect pests and have the potential to become biological control agents against these pests.

Results
In the present study, nine fly species of potential importance in biological pest control are recorded for the first time from Saudi Arabia, namely, Spogostylum ventrale Bezzi, 1924, Prothaplocnemis anthracina (Becker, 1902) [family Bombyliidae], Alloxytropus anomalus Bezzi, 1925, Scenopinus minusculus (Séguy, 1934) [family Scenopinidae], Actorthia frontata Kröber, 1912, Hoplosathe brevistyla Lyneborg & Zaitzev, 1980 [family Therevidae], Hilara sp. [family Empididae], Tomosvaryella demeyeri Kuznetzov, 1993 [family Pipunculidae] and Orchisia costata (Meigen, 1826) [family Muscidae]. In addition, this is the first time to record the four genera Prothaplocnemis Bezzi, Alloxytropus Bezzi, Hilara Meigen and Orchisia Rondani from Saudi Arabia. World and local distributions, diagnoses, feeding behaviors and some colored photographs of recorded species are provided.

Conclusion
In the present study, nine species of predacious and parasitic flies belonging to nine genera and six families are recorded for the first time in Saudi Arabia.
Subthalamic 85 Hz deep brain stimulation improves walking pace and stride length in Parkinson’s disease patients
Authors: Mügge F. , Kleinholdermann U. , Heun A. , Ollenschläger M. , Hannink J. , Pedrosa D. J. 
Published: August 2023

Abstract
Background
Mobile gait sensors represent a compelling tool to objectify the severity of symptoms in patients with idiopathic Parkinson’s disease (iPD), but also to determine the therapeutic benefit of interventions. In particular, parameters of Deep Brain stimulation (DBS) with its short latency could be accurately assessed using sensor data. This study aimed at gaining insight into gait changes due to different DBS parameters in patients with subthalamic nucleus (STN) DBS.

Methods
An analysis of various gait examinations was performed on 23 of the initially enrolled 27 iPD patients with chronic STN DBS. Stimulation settings were previously adjusted for either amplitude, frequency, or pulse width in a randomised order. A linear mixed effects model was used to analyse changes in gait speed, stride length, and maximum sensor lift.

Results
The findings of our study indicate significant improvements in gait speed, stride length, and leg lift measurable with mobile gait sensors under different DBS parameter variations. Notably, we observed positive results at 85 Hz, which proved to be more effective than often applied higher frequencies and that these improvements were traceable across almost all conditions. While pulse widths did produce some improvements in leg lift, they were less well tolerated and had inconsistent effects on some of the gait parameters. Our research suggests that using lower frequencies of DBS may offer a more tolerable and effective approach to enhancing gait in individuals with iPD.

Conclusions
Our results advocate for lower stimulation frequencies for patients who report gait difficulties, especially those who can adapt their DBS settings remotely. They also show that mobile gait sensors could be incorporated into clinical practice in the near future.
Serum S100B is related to insulin resistance and zinc-α2-glycoprotein levels in patients with chronic schizophrenia
Authors: Kalejahi Parinaz , Kheirouri Sorayya , Noorazar Seyed Gholamreza 
Published: August 2023

Abstract
Background
Elevated serum levels of S100B may associate with insulin resistance and other metabolic complication in schizophrenia patients. The aim of this study was to investigate the association of serum S100B levels with cardiometabolic parameters, serum levels of zinc-α2-glycoprotein (ZAG), and the severity of schizophrenia symptoms in schizophrenic patients. We recruited 42 patients with chronic schizophrenia. The participant's body weight (BW), waist circumference (WC), and blood pressure (BP) were measured. Serum levels of low and high-density lipoprotein cholesterol (LDL-c and HDL-C), triglyceride (TG), cholesterol (CHOL), fasting blood glucose (FBG), insulin, S100B, and ZAG levels were determined. The Homeostatic Model Assessment (HOMA) was used to quantify insulin resistance (IR) and the severity of schizophrenia was measured using a positive and negative syndrome scale (PANSS) score.

Results
The results showed that the mean serum S100B levels increased significantly with increasing HOMA-IR and ZAG levels (β = 0.595, 95% confidence interval (CI) (8.722 to 26.002), p < 0.001; and β = 0.334, 95% CI 0.067 to 0.525, p = 0.013 respectively). Patients under treatment with atypical antipsychotic medications (AAPM) had lower serum S100B levels (p = 0.035).

Conclusion
Our results suggest that alteration in glucose metabolism and ZAG secretion may increase serum S100B levels in patients with schizophrenia.
Hepatic artery infusion chemotherapy for advanced hepatocellular carcinoma
Authors: Houseni Mohamed , Hady Mahmoud Abdel Aziz Abdel , Abokoura Sameh 
Published: August 2023

Abstract
Objective:
This study’s purpose was to evaluate the response, safety and overall survival of trans-arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma with preserved hepatic function.

Methods:
This study was carried out on 25 patients, diagnosed with hepatocellular carcinoma (HCC) combined with portal vein tumor thrombosis (PVTT) and underwent hepatic artery infusion chemotherapy (HAIC). Radiological investigations as Triphasic CT or dynamic MRI liver assessment pre and post therapy were acquired. Intra-Arterial chemotherapeutic agent infusion using only doxorubicin was performed.

Results:
Neither of the patients who underwent HAIC developed complete or partial response. Only one patient (4.8%) from 21 patients under HAIC had stable disease. 20 patients (95%) had progressive disease. Progressive disease was in form of progression at the primary tumor site in form of increased focal lesion size, number or vascular invasion. Vascular invasion was seen in one patient (4.8%) in the form of hepatic vein thrombosis. Mean progression free survival was about 2.24 ± 0.88 months. Mean overall survival was about 5.72 ± 0.89 months.

Conclusion:
Our study demonstrated lower clinical efficacy and lower disease control rate of repeated HAIC using doxorubicin only infusion in case of advanced HCC with PVT as compared to combined doxorubicin and cisplatin in previous studies as well as the standard therapy with sorafenib.
Metabolites as Risk Factors for Diabetic Retinopathy in Patients With Type 2 Diabetes: A 12-Year Follow-up Study
Authors: Fernandes Silva Lilian , Hokkanen Jenna , Vangipurapu Jagadish , Oravilahti Anniina , Laakso Markku 
Published: August 2023

Abstract

Context
Diabetic retinopathy (DR) is a specific microvascular complication in patients with diabetes and the leading cause of blindness. Recent advances in omics, especially metabolomics, offer the possibility identifying novel potential biomarkers for DR.

Objective
The aim was to identify metabolites associated with DR.

Methods
We performed a 12-year follow-up study including 1349 participants with type 2 diabetes (1021 without DR, 328 with DR) selected from the METSIM cohort. Individuals who had retinopathy before the baseline study were excluded (n = 63). The diagnosis of retinopathy was based on fundus photography examination. We performed nontargeted metabolomics profiling to identify metabolites.

Results
We found 17 metabolites significantly associated with incident DR after adjustment for confounding factors. Among amino acids, N-lactoyl isoleucine, N-lactoyl valine, N-lactoyl tyrosine, N-lactoyl phenylalanine, N-(2-furoyl) glycine, and 5-hydroxylysine were associated with an increased risk of DR, and citrulline with a decreased risk of DR. Among the fatty acids N,N,N-trimethyl-5-aminovalerate was associated with an increased risk of DR, and myristoleate (14:1n5), palmitoleate (16:1n7), and 5-dodecenoate (12:1n7) with a decreased risk of DR. Sphingomyelin (d18:2/24:2), a sphingolipid, was significantly associated with a decreased risk of DR. Carboxylic acid maleate and organic compounds 3-hydroxypyridine sulfate, 4-vinylphenol sulfate, 4-ethylcatechol sulfate, and dimethyl sulfone were significantly associated with an increased risk of DR.

Conclusion
Our study is the first large population-based longitudinal study to identify metabolites for DR. We found multiple metabolites associated with an increased and decreased risk for DR from several different metabolic pathways.
Convertase-dependent regulation of membrane-tethered and secreted ligands tunes dendrite adhesion
Authors: Ramirez-Suarez Nelson J. , Belalcazar Helen M. , Rahman Maisha , Trivedi Meera , Tang Leo T. H. , Bülow Hannes E. 
Published: August 2023

ABSTRACT
During neural development, cellular adhesion is crucial for interactions among and between neurons and surrounding tissues. This function is mediated by conserved cell adhesion molecules, which are tightly regulated to allow for coordinated neuronal outgrowth. Here, we show that the proprotein convertase KPC-1 (homolog of mammalian furin) regulates the Menorin adhesion complex during development of PVD dendritic arbors in Caenorhabditis elegans. We found a finely regulated antagonistic balance between PVD-expressed KPC-1 and the epidermally expressed putative cell adhesion molecule MNR-1 (Menorin). Genetically, partial loss of mnr-1 suppressed partial loss of kpc-1, and both loss of kpc-1 and transgenic overexpression of mnr-1 resulted in indistinguishable phenotypes in PVD dendrites. This balance regulated cell-surface localization of the DMA-1 leucine-rich transmembrane receptor in PVD neurons. Lastly, kpc-1 mutants showed increased amounts of MNR-1 and decreased amounts of muscle-derived LECT-2 (Chondromodulin II), which is also part of the Menorin adhesion complex. These observations suggest that KPC-1 in PVD neurons directly or indirectly controls the abundance of proteins of the Menorin adhesion complex from adjacent tissues, thereby providing negative feedback from the dendrite to the instructive cues of surrounding tissues.
Harnessing developmental cues for cardiomyocyte production
Authors: Maas Renee G. C. , van den Dolder Floor W. , Yuan Qianliang , van der Velden Jolanda , Wu Sean M. , Sluijter Joost P. G. , Buikema Jan W. 
Published: August 2023

ABSTRACT
Developmental research has attempted to untangle the exact signals that control heart growth and size, with knockout studies in mice identifying pivotal roles for Wnt and Hippo signaling during embryonic and fetal heart growth. Despite this improved understanding, no clinically relevant therapies are yet available to compensate for the loss of functional adult myocardium and the absence of mature cardiomyocyte renewal that underlies cardiomyopathies of multiple origins. It remains of great interest to understand which mechanisms are responsible for the decline in proliferation in adult hearts and to elucidate new strategies for the stimulation of cardiac regeneration. Multiple signaling pathways have been identified that regulate the proliferation of cardiomyocytes in the embryonic heart and appear to be upregulated in postnatal injured hearts. In this Review, we highlight the interaction of signaling pathways in heart development and discuss how this knowledge has been translated into current technologies for cardiomyocyte production.
Y-27632 acts beyond ROCK inhibition to maintain epidermal stem-like cells in culture
Authors: Witkowski Travis A. , Li Bin , Andersen Jason G. , Kumar Bhavna , Mroz Edmund A. , Rocco James W. 
Published: August 2023

ABSTRACT
Conditional reprogramming is a cell culture technique that effectively immortalizes epithelial cells with normal genotypes by renewing epidermal stem cells. Y-27632, a compound that promotes conditional reprogramming through an unknown mechanism, was developed to inhibit the two Rho-associated kinase (ROCK) isoforms. We used human foreskin keratinocytes (HFKs) to study the role of Y-27632 in conditional reprogramming and learn how ROCKs control epidermal stem cell renewal. In conditional reprogramming, Y-27632 increased HFK adherence to culture dishes, progression through S, G2 and M phases of the cell cycle, and epidermal stem cell marker levels. Although this correlated with ROCK inhibition by Y-27632, we generated CRISPR–Cas9-mediated HFK ROCK knockouts to test the direct role of ROCK inhibition. Knockout of single ROCK isoforms was insufficient to disrupt ROCK activity or promote HFK propagation without Y-27632. Although ROCK activity was reduced, HFKs with double knockout of ROCK1 and ROCK2 still required Y-27632 to propagate. Y-27632 was the most effective among the ROCK inhibitors we tested at promoting HFK proliferation and epidermal stem cell marker expression. Thus, the ability of Y-27632 to promote an epidermal stem cell state in conditional reprogramming not only depends upon ROCK inhibition but also acts via as-yet-unidentified mechanisms. Epidermal stem cell renewal might in part be regulated by ROCKs, but also involves additional pathways.
Quartz crystal based sensor head design and analysis for robot torque sensor application
Authors: Fu Hao , Chen ChinYin , Wang Chongchong , Chao MinChiang , Zhou Qiang , Yang Guilin , Wang Guozhi 
Published: August 2023

Background: Background: In recent years, with the gradual development of robot human-computer interaction, robots need to meet the precise control of more complex movements. Torque sensors play an important role. The traditional sensor uses metal strain gauge as the sensing element, which makes the sensor slow in response and low in resolution. In view of the shortcomings of strain gauge sensor, a sensor with cut quartz square as the sensing head is proposed. Methods: In order to study the quartz square sensitive head, COMSOL56 simulation modeling was first used to obtain the stress ratio relationship between the square quartz chip and the circular quartz chip. The formula for calculating the force frequency coefficient of the circular quartz chip was modified based on the ratio coefficient, and the formula for calculating the force frequency coefficient of the square quartz chip was obtained. The feasibility of the formula was verified through practical experiments; Secondly, theoretical simulation and experimental research were conducted on the buckling limit force of quartz chips, and the calculation formula for the buckling limit force during the installation process of quartz chips was revised, laying the foundation for the theoretical design of quartz sensors; Finally, the designed sensitive head is installed on the elastomer structure for verification; In order to collect frequency signals at a sampling rate of 1000Hz, the frequency signal output by the square quartz sensitive head is mixed, filtered, and amplified to form a 3.3V square wave between peaks. The frequency signal is collected by STM32. Conclusion: the test shows that the sensor with square quartz chip as the sensor head has a range of 150Nm, a sensitivity of 350 Hz / Nm, a linearity of 98.14%, a hysteresis of 0.51%, a repeatability of 98.44% and a resolution of 0.02%.
New findings on ligand series used as SARS-CoV-2 virus inhibitors within the frameworks of molecular docking, molecular quantum similarity and chemical reactivity indices
Authors: Morales-Bayuelo Alejandro , Sánchez-Márquez Jesús 
Published: August 2023

Background: The severe acute respiratory syndrome coronavirus (SARS-CoV)-2 virus causes an infectious illness named coronavirus disease 2019 (COVID-19). SARS-CoV is a positive-sense single-stranded RNA virus from the Betacoronavirus genus. The SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) has an important role in the viral life cycle and its active site is a very accessible region, thus a potential therapeutic approach may be to target this region to study the inhibition of viral replication. Various preexisting drugs have been proposed for the treatment of COVID-19 and the use of existing antiviral agents may reduce the time and cost of new drug discoveries, but the efficacy of these drugs is limited. Therefore, the aim of the present study was to evaluate a number of ligands used as SARS-CoV-2 virus inhibitors to determine the suitability of them for potential COVID-19 treatment. Methods: In this study, we selected a series of ligands used as SARS-CoV-2 virus inhibitors such as: abacavir, acyclovir, amprenavir, ascorbic acid vitamin C, azithromycin, baloxavir, boceprevir, cholecalciferol vitamin D, cidofovir, edoxudine, emtricitabine, hydroxychloroquine and remdesivir. These ligands were analyzed using molecular docking, molecular quantum similarity, and chemical reactivity indices defined within a conceptual density functional theory framework. Results: The analysis of molecular quantum similarity indices on inhibitors showed a high number of differences from a structural point of view. However, they are quite similar in their electronic density, obtaining the highest values in the electronic similarity index. Global and local chemical reactivity indices were analyzed. Conclusions: These studies allowed for the identification of the main stabilizing interactions using the crystal structure of SARS-CoV-2 RdRp. The molecular quantum similarity and chemical reactivity descriptors provide novel insights into these ligands that can be used in the design of new COVID-19 treatments.
The odd log-logistic generalized exponential distribution: Application on survival times of chemotherapy patients data
Authors: Fulment Arnold K. , Gadde Srinivasa Rao , Peter Josephat K. 
Published: August 2023

Background: The creation of developing new generalized classes of distributions has attracted applied and theoretical statisticians owing to their properties of flexibility. The development of generalized distribution aims to find distribution flexibility and suitability for available data. In this decade, most authors have developed classes of distributions that are new, to become valuable for applied researchers. Methods: This study aims to develop the odd log-logistic generalized exponential distribution (OLLGED), one of the lifetime newly generated distributions in the field of statistics. The advantage of the newly generated distribution is the heavily tailed distributed lifetime data set. Most of the probabilistic properties are derived including generating functions, moments, and quantile and order statistics. Results: Estimation of the model parameter is done by the maximum likelihood method. The performance of parametric estimation is studied through simulation. Application of OLLGED and its flexibilities is done using two data sets and while its performance is done on the randomly simulated data set. Conclusions: The application and flexibility of the OLLGED are ensured through empirical observation using two sets of lifetime data, establishing that the proposed OLLGED can provide a better fit in comparison to existing rival models, such as odd generalized log-logistic, type-II generalized log-logistic, exponential distributions, odd exponential log-logistic, generalized exponential, and log-logistic.
A cross-sectional study on exploring the antecedents of patient’s revisit intention: Mediating role of trust in the hospital among patients in India
Authors: Akthar Nahima , Nayak Smitha , Pai P Yogesh 
Published: August 2023

Background: In the healthcare domain, patients’ trust in the hospital plays an instrumental role in determining the behavioral intention of the patient. This article attempts to investigate the impact of service quality perception on behavioral intention with the mediating effect of trust in the hospital and patient satisfaction. Methods: This research was carried out in multispecialty hospitals located in Bangalore Urban and Mysore districts of Karnataka during August 2021. This was a questionnaire-based study and the sample size was 242. Statistical Package for the Social Science (SPSS) 27.0 and SmartPLS 3.0 software was used to analyze the data. Results: The findings revealed that perceived service quality significantly influences trust through patient satisfaction (observed partial mediation) and patient satisfaction significantly impacts behavioral intention through trust (observed partial mediation). Conclusion: This study empowers hospital managers to understand the factors influencing behavioral intention. Healthcare professionals must ensure that good quality service is delivered to enhance patient satisfaction and trust in adverse services, which influence behavioral intention among the patients.
Community preventive behaviour and perception on the severity of COVID-19 disease in Indonesia, 2021-2022: Structural equation modelling
Authors: Eryando Tris , Sipahutar Tiopan , Poddar Sandeep 
Published: August 2023

Background: This study investigated the determinants of community preventive behavior in complying with the Indonesian regulations to prevent COVID-19 local transmission. Methods: A cross-sectional study used to collect the data via an online cross using a form created from a google questionnaire forms. A total of 1,802 respondents were gathered at a single point in time. The authors used the Health Belief Model (HBM) approach to measure and create a model of preventive behavior for COVID-19. Results: The findings showed that self-efficacy and perceived barriers had statistically significant relationships with preventive behavior. However, the goodness of fit index showed that the proposed model was not fit for the data, which means that it was not fit to describe the empirical phenomenon under study. Conclusions: This study found that more than half of the respondents still had low perceived susceptibility and severity. Only a few respondents had significant barriers to implementing COVID-19 transmission prevention behaviors. Still, most respondents had low perceived self-efficacy, and only 60% had good behaviors related to COVID-19 prevention. We recommended increasing perceived susceptibility and severity by providing the correct information about COVID-19 in the local cultural context.