bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large detrital zircon data set investigation and provenance mapping: Local versus regional and continental sediment sources before, during, and after Ancestral Rocky Mountain deformation
Authors: Smith Tyson M. , Saylor Joel E. , Lapen Tom J. , Leary Ryan J. , Sundell Kurt E. 
Published: March 2023

The increasing number and size of detrital geochronology data sets offer new opportunities for increased accuracy and resolution of sediment routing models. However, the new opportunities come coupled with challenges in large data integration and visualization. We address these challenges by outlining two novel approaches that aid in analyzing and interpreting large detrital geochronology data sets: (1) combination of bottom-up and top-down detrital zircon source modeling, and (2) sediment provenance mapping. Combining source-modeling methods provides guidance in identifying empirical detrital zircon sources and determining source proportions. Provenance mapping integrates source proportions from modeling results and complimentary geologic data (e.g., paleocurrents, paleogeography, and stratal thickness maps) to extrapolate provenance information through areas with sparse or ambiguous data, thus mitigating issues of data distribution heterogeneity. Sediment provenance maps also provide a synoptic view of data that, along with detrital zircon source modeling, aids in circumventing lengthy descriptions of individual age modes for data sets containing hundreds of samples, which can obscure underlying trends in the data.
We apply this approach to late Paleozoic−early Mesozoic strata, using 329 published and new U-Pb detrital zircon samples, and document five sediment-routing episodes in the core zone of intraplate deformation in western Laurentia (i.e., the Ancestral Rocky Mountains (ARM)). The transitions between these episodes are defined by changes in sediment source distribution, which are illustrated by provenance maps that show (1) the degree and extent of ARM basin isolation from transcontinental sediment sources and (2) ARM-driven changes in transcontinental sediment routing systems. We map possible sediment pathways of distally derived sediment around the ARM core, illustrating that ARM uplifts diverted transcontinental systems around areas of intense intraplate deformation. Further, the evolution of sediment routing in western Laurentia before, during, and after ARM deformation provides an example of the interaction between transcontinental sediment routing and intraplate deformation.
Similar body composition, muscle size, and strength adaptations to resistance training in lacto-ovo-vegetarians and non-vegetarians
Authors: Martini Gabriela Lucciana , Pinto Ronei Silveira , Brusco Clarissa Müller , Franceschetto Bianca Fasolo , Oliveira Mateus Leite , Neske Rodrigo , Cadore Fabricio Lusa , Teodoro Juliana Lopes , Wilhelm Eurico Nestor , de Souza Carolina Guerini 
Published: March 2023

There is a popular belief that meat consumption is necessary to optimize adaptations to strength training (ST), but evidence to support this hypothesis is scarce. Therefore, this study aimed to compare ST adaptations in lacto-ovo-vegetarians (LOV) and non-vegetarians (NV) with adjusted protein intake per meal. Sixty-four LOV and NV performed 12 weeks of ST and were instructed to ingest at least 20 g of protein in each main meal during the experimental period. Quadriceps femoris muscle thickness (QFMT), knee extension one-repetition maximum (1RM), and isometric peak torque (PT), as well as participants’ body composition were assessed before and after the intervention. Dietary intake was assessed throughout the study. After 12 weeks, similar increases in QFMT (LOV: 9.2 ± 5.4; NV: 5.5 ± 8.1 mm), knee extension 1RM (LOV: 24.7 ± 11.1; NV: 21.6 ± 9.8 kg), and PT (LOV: 29.8 ± 33.4; NV: 17.5 ± 19.4 N m) and lean body mass (LOV: 1.3 ± 0.9; NV: 1.4 ± 1.4 kg), alongside a decrease in body fat mass (LOV: −0.5 ± 1.6; NV −0.8 ± 1.6 kg) were observed in both groups at the end of the training period ( p < 0.05). LOV had lower protein consumption than NV throughout the study ( p < 0.05), but participants reached intake of at least 1.2 g of protein/kg/day during the experimental period. In conclusion, LOV and NV displayed similar improvements in muscle mass, strength, and in body composition after 12 weeks of ST, suggesting that meat consumption and higher protein intake in NV did not bring about further benefits to early adaptations to ST. This study was registered in Clinical Trials (NCT03785002) on 24 December 2018.
Moving Forward Liquid Biopsy in Early Liver Cancer Detection
Authors: Rolfo Christian , Russo Alessandro 
Published: March 2023

Summary:Early cancer detection is an attractive and promising application for liquid biopsy that might revolutionize cancer screenings. In this issue of Cancer Discovery, Foda and colleagues expand the potential utility of a machine learning fragmentome-based model, called DELFI, for detecting liver cancer in high-risk patients.See related article by Foda et al., p. 616 (5).
Diverse MJO Genesis and Predictability
Authors: Wei Yuntao , Ren Hong-Li , Xiang Baoqiang , Wang Yan , Wu Jie , Wang Shuguang 
Published: March 2023

Abstract
The Madden–Julian oscillation (MJO) is the dominant intraseasonal wave phenomenon influencing extreme weather and climate worldwide. Realistic simulations and accurate predictions of MJO genesis are the cornerstones for successfully monitoring, forecasting, and managing meteorological disasters 3–4 weeks in advance. Nevertheless, the genesis processes and emerging precursor signals of an eastward-propagating MJO event remain largely uncertain. Here, we find that the MJO genesis processes observed in the past four decades exhibit remarkable diversity with different seasonality and can be classified objectively into four types, namely, a novel downstream origin from the westward-propagating intraseasonal oscillation (WPISO; 20.4%), localized breeding from the Indian Ocean suppressed convection (IOSC; 15.4%), an upstream succession of the preceding weakly dispersive (WD; 25.9%), and strongly dispersive (SD; 38.3%) MJO. These four types are associated with different oceanic background states, characterized by central Pacific cooling, southern Maritime Continent warming, eastern Pacific cooling, and central Pacific warming for the WPISO, IOSC, WD, and SD types, respectively. The SD type is also favored during the easterly phase of the stratospheric quasi-biennial oscillation. Diverse convective initiations possibly imply various kinds of propagations of MJO. The subseasonal reforecasts indicate robustly distinct prediction skills for the diverse MJO genesis. A window of opportunity for skillful week 3–4 prediction probably opens with the aid of the WPISO-type MJO precursor, which has increased the predictability of primary MJO onset by 1 week. These findings suggest that the diversified MJO genesis can be skillfully foreseen by monitoring unique precursor signals and can also serve as benchmarks for evaluating contemporary models’ modeling and predicting capabilities.
Examining the outcomes of the first one hundred residents in a community based residential rehabilitation unit for people affected by severe and persistent mental illness
Authors: Korman Nicole , Ng Joanna , Gore-Jones Victoria , Dark Frances , Parker Stephen 
Published: March 2023

Objective Community-based residential rehabilitation for people experiencing severe and persistent mental illness (SPMI) is increasingly available as an alternative to psychiatric inpatient care. Understanding who accesses these services and their outcomes will inform the optimal allocation of limited public mental health resources. Method This retrospective cohort study explored the outcomes of the first 100 consumers supported by a new Australian Community Care Unit (CCU). The primary outcome focus was acute mental health service use (emergency department presentations, acute mental health inpatient admission days), and secondary outcome foci were accommodation independence and substance use. Results When the 365 days before and after CCU support were compared, significant reductions in acute mental health bed days were observed (22 days, W = 3.373, p = .001); greater reductions were noted for those staying >182 days (31 days, W = 3.373, p = .001). Additionally, significant improvements in accommodation independence were found, (W = 3.373, p = .001). Conclusion CCU consumers experienced reductions in acute mental health inpatient service use and improved accommodation independence. These observations are consistent with the intended functioning of the residential rehabilitation service.
Commonly diagnosed disorders in domestic cats in the UK and their associations with sex and age
Authors: O’Neill Dan G , Gunn-Moore Danièlle , Sorrell Stephanie , McAuslan Harriet , Church David B , Pegram Camilla , Brodbelt Dave C 
Published: March 2023

Objectives The objectives of this study were to generate a robust evidence base on the prevalence of common disorders in cats and develop a deeper understanding of disorder associations with sex and age that could offer important opportunities for targeted veterinary care to improve feline health and welfare. Methods A random sample of 18,249 cats was obtained from 1,255,130 cats under primary care during 2019 within VetCompass, an epidemiological research programme based on anonymised primary care veterinary clinical records. All disorders recorded during 2019 were extracted and reported, and associations with sex and age were examined. Results The most prevalent disorders were periodontal disease (n = 2780 [15.2%], 95% confidence interval [CI] 14.72–15.76), obesity (n = 2114 [11.6%], 95% CI 11.12–12.06) and dental disease (n = 1502 [8.2%], 95% CI 7.84–8.64). Compared with male cats, females had an increased prevalence of poor quality of life, postoperative complications and hyperthyroidism, among others. Male cats had a higher prevalence of periodontal disease, road traffic accident (RTA) and obesity. Younger cats (<8 years) had an increased prevalence of cat bite abscess, flea infestation and RTA, while older cats (⩾8 years) had increased prevalence of lameness, cystitis and dental disease, among others. Conclusions and relevance These findings suggest that the veterinary profession needs to engage more effectively in informing owners on common preventable disorders (ie, obesity and dental disease). This new information can contribute to more targeted health surveillance and more effective veterinary interventions to promote improved health and welfare in pet cats. Large-scale collection and analysis of anonymised veterinary clinical records offer an important clinical resource for research.
A wearable electronic based on flexible pressure sensor for running motion monitoring
Authors: Chang Xiaoming 
Published: March 2023

AbstractThe flexible pressure sensor is expected to be applied in the new generation of sports wearable electronic devices. Developing flexible pressure sensors with a wide linear range and great sensitivity, however, remains a significant barrier. In this work, we propose a hybrid conductive elastomeric film oxide-based material with a concave-shape micro-patterned array (P-HCF) on the surface that sustainably shows the necessary sensing qualities. To enhance sensing range and sensitivity, one-dimensional carbon fibers and two-dimensional MXene are incorporated into the polydimethylsiloxane matrix to form a three-dimensional conductive network. Micro-patterns with a curved shape in P-HCFs can be able to linear sensitivity across the sensing range by controlling the pressure distribution inside the material. Besides, the sensitivity of P-HCF pressure sensor can reach 31.92 kPa−1, and meanwhile, the linear band of P-HCF pressure sensor can arrive at 24 Pa–720 kPa, which makes it a good choice for sports monitoring. The designed pressure sensor can be used to monitor the foot pressure during running. By analyzing the gait information during running, it can provide data support and strategy improvement for running. This new dual working mode pressure P-HCF sensor will provide a new way for the development of intelligent sports.
Of primary health care reforms and pandemic responses: understanding perspectives of health system actors in Kerala before and during COVID-19
Authors: Sankar D Hari , Joseph Jaison , Benny Gloria , Nambiar Devaki 
Published: March 2023

Abstract
Background
In 2016, the Government of the southern Indian state of Kerala launched the Aardram mission, a set of reforms in the state’s health sector with the support of Local Self Governments (LSG). Primary Health Centres (PHCs) were slated for transformation into Family Health Centres (FHCs), with extended hours of operation as well as improved quality and range of services. With the COVID-19 pandemic emerging soon after their introduction, we studied the outcomes of the transformation from PHC to FHC and how they related to primary healthcare service delivery during COVID-19.

Methods
A qualitative study was conducted using In-depth interviews with 80 health system actors (male n = 32, female n = 48) aged between 30–63 years in eight primary care facilities of four districts in Kerala from July to October 2021. Participants included LSG members, medical and public health staff, as well as community leaders. Questions about the need for primary healthcare reforms, their implementation, challenges, achievements, and the impact of COVID-19 on service delivery were asked. Written informed consent was obtained and interview transcripts – transliterated into English—were thematically analysed by a team of four researchers using ATLAS.ti 9 software.

Results
LSG members and health staff felt that the PHC was an institution that guarantees preventive, promotive, and curative care to the poorest section of society and can help in reducing the high cost of care. Post-transformation to FHCs, improved timings, additional human resources, new services, fully functioning laboratories, and well stocked pharmacies were observed and linked to improved service utilization and reduced cost of care. Challenges of geographical access remained, along with concerns about the lack of attention to public health functions, and sustainability in low-revenue LSGs. COVID-19 pandemic restrictions disrupted promotive services, awareness sessions and outreach activities; newly introduced services were stopped, and outpatient numbers were reduced drastically. Essential health delivery and COVID-19 management increased the workload of health workers and LSG members, as the emphasis was placed on managing the COVID-19 pandemic and delivering essential health services.

Conclusion
Most of the health system actors expressed their belief in and commitment to primary health care reforms and noted positive impacts on the clinical side with remaining challenges of access, outreach, and sustainability. COVID-19 reduced service coverage and utilisation, but motivated greater efforts on the part of both health workers and community representatives. Primary health care is a shared priority now, with a need for greater focus on systems strengthening, collaboration, and primary prevention.
A dyadic advance care planning intervention for people with early-stage dementia and their family caregivers in a community care setting: a feasibility trial
Authors: Yeung Cheryl Chi-yan , Ho Ken Hok-man , Chan Helen Yue-lai 
Published: March 2023

Abstract
Background
Advance care planning (ACP) is highly relevant for people with early-stage dementia to communicate their care preferences for serious illness conditions with their family caregivers before they become mentally incapacitated.

Methods
A multi-centre, quasi-experimental study was conducted to test the feasibility and acceptability of a theory-guided, dyadic ACP intervention (‘Have a Say’ programme) among participants with early-stage dementia–family caregiver dyads. The feasibility of the trial design, intervention procedures, subject recruitment and retention, and study instruments were assessed. Study outcomes were measured at baseline (T0), immediately after the intervention (T1), and at 1 month (T2) and 3 months post-intervention (T3). Acceptability of the intervention was determined by the satisfaction score, completion rate and qualitative interviews as process evaluation with a purposive sample of participants and ACP facilitators. Generalised estimating equations were performed to examine differential changes between groups over time, with covariates adjusted.

Results
Subject recruitment from five elderly community centres yielded a recruitment rate of 60% and resulted in 36 client–caregiver dyads. The intervention was acceptable to the dyads, with a mean satisfaction score of 4.4 out of 5 and completion rate of 94.4%. The attrition rates at T1, T2, and T3 were 8.3%, 13.9%, and 19.4%, respectively. The intervention group reported a significantly greater improvement in the readiness for ACP at T1, self-efficacy for ACP at T3, and dyadic concordance on end-of-life care preferences at all time points than the control group, but not on depressive symptoms. Family caregivers in the intervention group reported a significantly higher caregiving burden at T2 than the control group. The qualitative findings revealed that triadic involvement of and trusting relationships among the dyads and ACP facilitators, and documentation of clients’ views are the programme strengths, while the structured format and discussion about medical issues posed implementation challenges.

Conclusions
This ACP intervention and trial design were feasible and acceptable to the dyads. Several refinements were identified, including adding a nurse-led group-based session for information giving, allowing flexibility in arrangement, and adding measure of ACP engagement of family caregivers. A rigorous trial to test the effects of the ACP intervention is warranted.

Trial registration
Retrospectively registered on 14/08/2020 at clinicaltrials.gov (Identifier: NCT04513106).
FtMt reduces oxidative stress-induced trophoblast cell dysfunction via the HIF-1α/VEGF signaling pathway
Authors: Xu Xia , Ye Xu , Zhu Mengwei , Zhang Qiuyu , Li Xiuli , Yan Jianying 
Published: March 2023

Abstract
Background
Preeclampsia (PE) is a complication of pregnancy that causes long-term adverse outcomes for the mother and fetus and may even lead to death. Oxidative stress caused by the imbalance of oxidants and antioxidants in the placenta has been considered as one of the key mechanisms of preeclampsia (together with inflammation, etc.), in which the placental mitochondria play an important role. The expression of hypoxia-inducible factor-1 (HIF-1α) and vascular endothelial growth factor (VEGF) is known to be increased in patients with PE. Mitochondrial ferritin (FtMt) is known to protect the mitochondria from oxidative stress, although its specific role in PE remains unclear.

Methods
We used qRT-PCR and western blotting to detect the expression levels of FtMt, HIF-1α, and VEGF in placental tissues from patients with PE. Human chorionic trophoblast cells were also administered with hypoxia treatment, followed by the detection of cell proliferation, invasion and angiogenic capacity by CCK8, Transwell, and endothelial cell angiogenesis assays; we also detected the expression of HIF-1α and VEGF in these cells. Finally, overexpression or inhibitory FtMt lentiviral vectors, along with negative control vectors, were constructed and transfected into hypoxia-treated human chorionic trophoblast cells; this was followed by analyses of cell function.

Results
The expression levels of FtMt, HIF-1α and VEGF in the PE group were higher than those in the control group (P < 0.05). Following hypoxia, there was an increase in the expression levels of HIF-1α and VEGF protein in trophoblast cells. There was also an increase in invasion ability and vascular formation ability along with a reduction in cell proliferation ability. These effects were reversed by transfecting cells with the knockout FtMt lentivirus vector. The differences were statistically significant.

Conclusion
Analyses showed that FtMt plays a key role in the vascular regulation of PE trophoblast cells after hypoxia possibly acting via the HIF-1α/VEGF signaling pathway. These results provide us an enhanced understanding of the pathogenesis of PE and suggest that the HIF-1α/VEGF signaling pathway represents a new target for the treatment of PE.
Developing an Inpatient Relationship Centered Communication Curriculum (I-RCCC) rounding framework for surgical teams
Authors: Nassar Aussama K. , Weimer‑Elder Barbette , Yang Rachel , Kline Merisa , Dang Bryan K. , Spain David A. , Knowlton Lisa M , Valdez Andre B. , Korndorffer James R. , Johnson Tyler 
Published: March 2023

Abstract
Background
Morning rounds by an acute care surgery (ACS) service at a level one trauma center are uniquely demanding, given the fast pace, high acuity, and increased patient volume. These demands notwithstanding, communication remains integral to the success of surgical teams. Yet there are limited published curricula that address trauma inpatient communication needs. Observations at our institution confirmed that the surgical team lacked a shared mental model for communication. We hypothesized that creating a relationship-centered rounding conceptual framework model would enhance the provider-patient experience.

Study design
A mixed-methods approach was used for this study. A multi-pronged needs assessment was conducted. Provider communion items for Press Ganey and Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) surveys were used to measure patients’ expressed needs. Faculty with experience in relationship-centered communication observed morning rounds and documented demonstrated behaviors. A five-hour workshop was designed based on the identified needs. A pre-and post-course Assessment and course evaluation were conducted. Provider-related patient satisfaction items were measured six months before the course and six months after the workshop.

Results
Needs assessment revealed a lack of a shared communication framework and a lack of leadership skills for senior trauma residents. Barriers included: time constraints, patient load, and interruptions during rounds. The curriculum was very well received. The self-reflected behaviors that demonstrated the most dramatic change between the pre and post-workshop surveys were: I listened without interrupting; I spoke clearly and at a moderate pace; I repeated key points; and I checked that the patient understood. All these changed from being performed by 50% of respondents “about half of the time” to 100% of them “always”. Press Ganey top box likelihood to recommend (LTR) and provider-related top box items showed a trend towards improvement after implementing the training with a percentage difference of up to 20%.

Conclusion
The Inpatient Relationship Centered Communication Curriculum (I-RCCC) targeting senior residents and Nurse Practitioners (NP) was feasible, practical, and well-received by participants. There was a trend of an increase in LTRs and provider-specific patient satisfaction items. This curriculum will be refined based on the study results and potentially scalable to other surgical specialties.