bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volumetric Growth and Growth Curve Analysis of Residual Intracranial Meningioma
Authors: Gillespie Conor S. , Richardson George E. , Mustafa Mohammad A. , Taweel Basel A. , Bakhsh Ali , Kumar Siddhant , Keshwara Sumirat M. , Islim Abdurrahman I. , Mehta Shaveta , Millward Christopher P. , Brodbelt Andrew R. , Mills Samantha J. , Jenkinson Michael D. 
Published: January 2023

BACKGROUND:
After meningioma surgery, approximately 1 in 3 patients will have residual tumor that requires ongoing imaging surveillance. The precise volumetric growth rates of these tumors are unknown.

OBJECTIVE:
To identify the volumetric growth rates of residual meningioma, growth trajectory, and factors associated with progression.

METHODS:
Patients with residual meningioma identified at a tertiary neurosurgery center between 2004 and 2020 were retrospectively reviewed. Tumor volume was measured using manual segmentation, after surgery and at every follow-up MRI scan. Growth rates were ascertained using a linear mixed-effects model and nonlinear regression analysis of growth trajectories. Progression was defined according to the Response Assessment in Neuro-Oncology (RANO) criteria (40% volume increase).

RESULTS:
There were 236 patients with residual meningioma. One hundred and thirty-two patients (56.0%) progressed according to the RANO criteria, with 86 patients being conservatively managed (65.2%) after progression. Thirteen patients (5.5%) developed clinical progression. Over a median follow-up of 5.3 years (interquartile range, 3.5–8.6 years), the absolute growth rate was 0.11 cm3 per year and the relative growth rate 4.3% per year. Factors associated with residual meningioma progression in multivariable Cox regression analysis were skull base location (hazard ratio [HR] 1.60, 95% CI 1.02–2.50) and increasing Ki-67 index (HR 3.43, 95% CI 1.19–9.90). Most meningioma exhibited exponential and logistic growth patterns (median R2 value 0.84, 95% CI 0.60–0.90).

CONCLUSION:
Absolute and relative growth rates of residual meningioma are low, but most meet the RANO criteria for progression. Location and Ki-67 index can be used to stratify adjuvant treatment and surveillance paradigms.
Evaluation of the Effects of Different Natural Dietary Feed Additives on Performance and Intestinal Histomorphology in Quails
Authors: Yesilbag D , Abdullahoglu E , Urkmez E , Acar A , Asmaz D , Kara M 
Published: January 2023

The aim of the present study was to investigate the influence of a commercial probiotic and a commercial essential oil blend and their mixture, as a natural feed additive, on growth parameters live weight (LW), live weight gain (LWG), feed intake (FI), feed conversion ratio (FCR), carcass yield (CY) and small intestinal histomorphology of quails. A total of 200 1-day-old Japanese (Coturnix coturnix japonica) quails, including both males and females, were divided into four groups containing 50 quails and treated as follows: (1) a control treatment without medication (2) 18 g ton-1 probiotic; (3) 300 g ton-1 essential oil blend and (4) 18 g ton-1 probiotic plus 300 g ton-1 essential oil blend. The results of the research show that the additives added to quail diets do not have a significant effect (P > 0.05) on the performance parameters of LW, LWG, FI and FCR. However, significant differences (P < 0.05) were found in the CY, which is one of the performance parameters. A probiotic addition of 18 g ton -1 (treatment 1) to the quail diet resulted in a significant increase (P < 0.05) in carcass yield. Moreover, the addition of natural feed additives such as probiotics, essential oil blends and mixture to quail diets caused significant (P < 0.001) increases in villus heights and crypt depth in the duodenum and ileum segments. In addition, significant (P < 0.05) enlargements were found in the villus surface area in the experimental groups compared to the control group. In conclusion, in this study, it was determined that the addition of feed additives, which are developed as an alternative to antibiotics to the quail diet did not have a negative effect on performance and caused significant differences in the effective parameters in the evaluation of intestinal health.
Biometric radiographic features between foot lesions and long toe under-run heel in donkeys
Authors: El-Marakby AI , Abdelgalil AI , Mostafa MB , Soliman AS 
Published: January 2023

AbstractThe present study aimed to document the relationship between biometric foot measurements and different radiographic lesions in a group of donkeys' feet with long toe under-run heel. The common radiographic foot lesions were pedal osteitis complex in 26 (86.6%) and navicular bone reaction in 8 (26.7%). Osteophyte reaction was identified at proximal phalanx in 8 (26.7%) and middle phalanx in 10 (33.3%). Pastern and coffin joints osteoarthritis were found in 4 (13.3%) and 9 (30%) respectively. Palmar soft tissue calcification and eminence of 2nd phalanx were reported in 5 (16.6%) and 1 (3.3%) respectively. The dorsal hoof wall angle (DHWA) was positive significantly correlated with the axis of the distal phalanx, distal phalanx and proximal palmar cortex angles, the heel angle, and distal phalanx solar border angle. The increased dorsal hoof wall length (DHWL) was positive strongly correlated with dorsal coronary band height, medial wall length, lateral wall length, lateral coronary band distance, medial coronary band distance, lateral distal phalanx to bottom distance, and medial distal phalanx to bottom distance. The dorsal hoof wall and heel angles reflected increased stress on the hoof capsule, distal interphalangeal joint, navicular bone, and palmar soft tissue structures. The low heel, the distal phalanx solar border angle and under development of the palmar section of the hoof indicated distal phalanx was slightly slippage dorsally, increased tension on the DDFT, navicular bone, and pedal osteitis complex in long toe under-run heels. This study demonstrated a relationship between biometric foot measurements and the presence of radiographic foot lesions detected in long toe under-run heel in donkeys.
Sepsis decreases lung SVEP1 expression in a murine model
Authors: Kurita Takeo , Oami Takehiko , Fujimura Lisa , Sakamoto Akemi , Sato-Nishiuchi Ryoko , Sekiguchi Kiyotoshi , Hatano Masahiko , Nakada Taka-aki 
Published: January 2023

Background: Genome-wide association studies have identified sushi, von Willebrand factor type A, EGF, and pentraxin domain-containing 1 (SVEP1) polymorphism as a genetic risk factor for sepsis, as well as acute coronary syndrome. However, research on the role of SVEP1 in systemic inflammation, such as surgical invasion and sepsis, remains insufficient. Therefore, we investigated SVEP1 gene expression and protein levels after surgical invasion and sepsis in mice. Methods: We compared the gene expression and protein levels of SVEP1 between the control (no surgery), sham operation model, and sepsis model with cecal ligation and puncture in mice. Samples were collected at 2, 6, and 24 h after surgery. Results: The lungs had high gene expression and protein production of SVEP1 at baseline. Sham operation and sepsis decreased SVEP1 gene expression in the lungs immediately after stimulation. Furthermore, sepsis significantly downregulated the gene expression compared with sham operation. Flow cytometric analysis showed that mice with sepsis had a significantly decreased percentage of CD31high / SVEP1high and lymphatic vessel endothelial receptor 1 (LYVE-1)high / SVEP1high cells and an increased percentage of CD45.2high / SVEP1high cells. Conclusions: Sepsis decreased SVEP1 gene expression in the lungs. Mice with sepsis had a decreased percentage of SVEP1high vascular and lymphatic endothelial cells and an increased percentage of SVEP1high hematopoietic cells.
Planar cell polarity proteins determine basal cell height in the later stage embryonic mouse epidermis'
Authors: Hobbs Carl , Formstone Caroline J. 
Published: January 2023

Background: Complex organ formation requires the coordinated morphogenesis of adjacent tissue layers. Here, we report a role for the planar cell polarity (PCP) proteins Fz6 and Celsr1 in generating squamous basal cells in the later stage embryonic epidermis of the mouse is reported, which may impact upon the shape of overlying suprabasal cells. Methods: The depth of the epidermis and basal layer as well as cell proliferation index was scored from immunostained wax sections taken from different mouse embryos mutant in planar cell polarity signalling and their wild-type littermates. Orientation of epidermal cell division in Celsr1 Crash/Crash mutants was determined from thick frozen immunostained sections. Immunostained wax sections of wild-type skin explants cultured using the Lumox method enabled any changes in epidermal and basal layer depth to be measured following the release of surface tension upon dissection of skin away from the whole embryo. Results: Increased numbers of columnar and cuboidal basal epidermal cells were observed in fz6-/- mutant and Celsr1 mouse mutant Crash/Crash which correlated with visibly more rounded suprabasal cells and a thicker epidermis. Conclusions: Altogether these data support tissue intrinsic roles for PCP proteins in ‘outside-in’ (radial) skin architecture.
Demonstration of a hybrid A-RoF/VLC system for beyond 5G applications
Authors: Andrade Tomás P. V. , Carneiro de Souza Letícia , Lima Eduardo Saia , Cerqueira Sodré Arismar 
Published: January 2023

This work reports the implementation of a fiber-optics and visible
light communication (VLC)-based flexible optical distribution network
for beyond the fifth generation of mobile networks (B5G) applications.
The proposed hybrid architecture is composed of a 12.5-km single-mode
fiber fronthaul based on the analog radio-over-fiber (A-RoF)
technology, followed by a red, green, and blue (RGB)-based VLC link of
1.2 m. As a proof of concept, we experimentally demonstrate a
successful deployment of a 5G hybrid A-RoF/VLC system without using
pre-/post-equalization, digital pre-distortion, or individual filters
for each color, by means of using a dichroic cube filter at the
receiver side. The system performance is evaluated in terms of the
root mean square error vector magnitude (EVMRMS), in accordance with the 3rd
Generation Partnership Project requirements, and as a function of the
light-emitting diodes’ injected electrical power and signal
bandwidth.
OPGW positioning and early warning method based on a Brillouin distributed optical fiber sensor and machine learning
Authors: Xia Meng , Tang Xiaohui , Wang Ying , Li Can , Wei Yong , Zhang Jiaju , Jiang Taofei , Dong Yongkang 
Published: January 2023

A method of optical fiber composite overhead ground wire (OPGW) positioning based on a Brillouin distributed optical fiber sensor and machine learning is proposed. A distributed Brillouin optical time-domain reflectometry (BOTDR) and Brillouin optical time-domain analyzer (BOTDA) are designed, where the ranges of BOTDR and the BOTDA are 110 km and 125 km, respectively. An unsupervised machine learning method density-based spatial clustering of applications with noise (DBSCAN) is proposed to automatically identify the splicing point based on the Brillouin frequency shift (BFS) difference of adjacent sections. An adaptive parameter selection method based on k-distance is adapted to overcome the parameter sensitivity. The validity of the proposed DBSCAN algorithm is greater than 96%, which is evaluated by three commonly external validation indices with five typical BFS curves. According to the clustering results of different fiber cores and the tower schedule of the OPGW, the connecting towers are distinguished, which is proved as a 100% recognition rate. According to the identification results of different fiber cores of both the OPGW cables and tower schedule, the connecting towers can be distinguished, and the distributed strain information is extracted directly from the BFS to strain. The abnormal region is positioned and warned according to the distributed strain measurements. The method proposed herein significantly improves the efficiency of fault positioning and early warning, which means a higher operational reliability of the OPGW cables.
Environmental enteric dysfunction and small intestinal histomorphology of stunted children in Bangladesh
Authors: Hossain Md. Shabab , Begum S. M. Khodeza Nahar , Rahman M Masudur , Parvez Mashud , Mazumder Ramendra Nath , Sarker Shafiqul Alam , Hasan Md. Mehedi , Fahim Shah Mohammad , Gazi Md. Amran , Das Subhasish , Mahfuz Mustafa , Ahmed Tahmeed 
Published: January 2023

There is lack of information on the histological characteristics of the intestinal mucosa in Bangladeshi children. Collection of intestinal biopsy samples and assessment of the histomorphological features is considered to be the traditional gold standard for diagnosis of environmental enteric dysfunction (EED). The purpose of the study was to evaluate the intestinal histological characteristics of stunted children aged between 12–18 months with possible EED. 110 children with chronic malnutrition (52 stunted with length-for-age Z score, LAZ<-2 and 58 at risk of stunting with LAZ <-1 to -2) from the Bangladesh Environmental Enteric Dysfunction (BEED) study protocol who underwent upper gastrointestinal (GI) endoscopy were selected for this study. To explore the association of EED with childhood stunting, upper GI endoscopy was done and the biopsy specimens were studied for histopathology. Villous height and crypt depth were measured and the presence and intensity of inflammatory infiltrates in the lamina propria was investigated. Bivariate analysis was performed to examine the relationship between stunting and histologic morphology. More than 90% children irrespective of nutritional status were diagnosed to have chronic non-specific duodenitis on histopathology. Half of the children from both groups had villous atrophy as well as crypt hyperplasia and lymphocytic infiltration was present in more than 90% children, irrespective of groups. However, no statistically significant difference was observed when compared between the groups. The prevalence of chronic non-specific duodenitis in Bangladeshi children, irrespective of nutritional status, was high. A significant number of these children had abnormal findings in intestinal histomorphology.
Trial registration number: ClinicalTrials.gov ID: NCT02812615 Date of first registration: 24/06/2016. https://clinicaltrials.gov/ct2/results?cond=NCT02812615&term=&cntry=&state=&city=&dist.
Understanding perceptions of schistosomiasis and its control among highly endemic lakeshore communities in Mayuge, Uganda
Authors: Mujumbusi Lazaaro , Nalwadda Edith , Ssali Agnes , Pickering Lucy , Seeley Janet , Meginnis Keila , Lamberton Poppy H. L. 
Published: January 2023

Background
Schistosomiasis is a neglected tropical disease and a serious global-health problem with over 230 million people requiring treatment, of which the majority live in Africa. In Uganda, over 4 million people are infected. Extensive parasitological data exist on infection prevalence, intensities and the impact of repeated praziquantel mass drug administration (MDA). However, how perceptions of schistosomiasis shape prevention and treatment practices and their implications for control measures are much less well understood.

Methods
Rapid ethnographic appraisals were performed for six weeks in each of three Schistosoma mansoni high endemicity communities on the shores of Lake Victoria, Mayuge District, Uganda. Data were collected between September 2017 and April 2018. Data were collected through structured observations, transect walks, and participant observation, and sixty in-depth interviews and 19 focus group discussions with purposively recruited participants. Data were analyzed thematically using iterative categorization, looking at five key areas: perceptions of 1) the symptoms of schistosomiasis; 2) the treatment of schistosomiasis; 3) how schistosomiasis is contracted; 4) how schistosomiasis is transmitted onwards and responsibilities associated with this; and 5) how people can prevent infection and/or onward transmission.

Results
Observations revealed open defecation is a common practice in all communities, low latrine coverage compared to the population, and all communities largely depend on lake water and contact it on a daily basis. Perceptions that a swollen stomach was a sign/symptom of ‘ekidada’ (caused by witchcraft) resulted in some people rejecting free praziquantel in favour of herbal treatment from traditional healers at a fee. Others rejected praziquantel because of its perceived side effects. People who perceived that schistosomiasis is caught from drinking unboiled lake water did not seek to minimize skin contact with infected water sources. Community members had varied perceptions about how one can catch and transmit schistosomiasis and these perceptions affect prevention and treatment practices. Open defecation and urinating in the lake were considered the main route of transmission, all communities attributed blame for transmission to the fishermen which was acknowledged by some fishermen. And, lastly, schistosomiasis was considered hard to prevent due to lack of access to safe water.

Conclusion
Despite over 15 years of MDA and associated education, common misconceptions surrounding schistosomiasis exist. Perceptions people have about schistosomiasis profoundly shape not only prevention but also treatment practices, greatly reducing intervention uptake. Therefore, we advocate for a contextualized health education programme, alongside MDA, implementation of improved access to safe-water and sanitation and continued research.
Integrated people-centered eye care: A scoping review on engaging communities in eye care in low- and middle-income settings
Authors: Lee Ling , Moo Elise , Angelopoulos Tiffany , Yashadhana Aryati 
Published: January 2023

BackgroundCommunity engagement has been endorsed as a key strategy to achieving integrated people-centered eye care that enables people and communities to receive a full spectrum of eye care across their life-course. Understanding the ways communities are engaged in eye care, to what degree participation is achieved, and the factors associated with intervention implementation is currently limited.ObjectiveThe scoping review aimed to assess how community engagement is approached and implemented in eye care interventions in low- and middle-income countries, and to identify the barriers and facilitators associated with intervention implementation.MethodsSearches were conducted across five databases for peer-reviewed research on eye care interventions engaging communities published in the last ten years (January 2011 to September 2021). Studies were screened, reviewed and appraised according to Cochrane Rapid Reviews methodology. A hybrid deductive-inductive iterative analysis approach was used.ResultsOf 4315 potential studies screened, 73 were included in the review. Studies were conducted across 28 countries and 55 targeted populations across more than one life-course stage. A variety of community actors were engaged in implementation, in four main domains of eye care: health promotion and education; drug and supplement distribution and immunization campaigns; surveillance, screening and detection activities; and referral and pathway navigation. With the approaches and level of participation, the majority of studies were community-based and at best, involved communities, respectively. Involving community actors alone does not guarantee community trust and therefore can impact eye care uptake. Community actors can be integrated into eye care programs, although with varying success. Using volunteers highlighted sustainability issues with maintaining motivation and involvement when resources are limited.ConclusionThis scoping review provides researchers and policy makers contextual evidence on the breadth of eye care interventions and the factors to be considered when engaging and empowering communities in integrated people-centered eye care programs.
Wheat ergot fungus-derived and modified drug for inhibition of intracranial aneurysm rupture due to dysfunction of TLR-4 receptor in Alzheimer’s disease
Authors: Debnath Sandip , Sharma Devesh , Chaudhari Somdatta Yashwant , Sharma Ritika , Shaikh Amir Afzal , Buchade Rahul Subhash , Kesari Kavindra Kumar , Abdel-Fattah Abdel-Fattah M. , Algahtani Mohammad , Mheidat Mayyadah , Alsaidalani Rawidh , Paul Tapas , Sayed Amany A. , Abdel-Daim Mohamed M. 
Published: January 2023

Background
Alzheimer’s disease (AD) is a form of dementia that strikes elderly people more frequently than it does younger people. The cognitive skills and memory of Alzheimer’s sufferers continue to deteriorate over time. Recent studies have shown that patients with AD have greater amounts of inflammatory markers in their bodies, which suggests that inflammation occurs early on in the progression of the disease. There is a possibility that Aß oligomers and fibrils can be recognised by TLRs, in addition to the microglial receptors CD14, CD36, and CD47. When Aß binds to either CD36 or TLR4, it sets off a chain reaction of inflammatory chemokines and cytokines that ultimately results in neurodegeneration. Diabetes and Alzheimer’s disease have both been recently related to TLR4. The activation of TLR4 has been connected to a variety of clinical difficulties that are associated with diabetes, in addition to the internal environment of the body and the microenvironment of the brain. TLR4 inhibitors have been shown in clinical investigations to not only lessen the likelihood of getting sick but also to increase the average longevity.

Result
In this work we used molecular docking and molecular dynamics modelling to investigate the effectiveness of FDA-approved antidiabetic plant derived drugs in combating the TLR4 receptor. Molecular docking experiments were used to make a prediction regarding the most important interactions involving 2-Bromoergocryptine Mesylate. With a binding affinity of -8.26 kcal/mol, it stood out from the other candidates as the one with the greatest potential. To verify the interaction pattern that takes place between 2-Bromoergocryptine Mesylate and the TLR4 receptor, a molecular dynamic simulation was run at a time scale of 150 nanoseconds. Because of this, 2-Bromoergocryptine Mesylate was able to make substantial contact with the active site, which led to increased structural stability during the process of the complex’s dynamic development.

Conclusion
As a result of this, the results of our research may be relevant for future research into the efficacy of 2-bromoergocryptine mesylate as a potential lead treatment for TLR4 receptors in intracranial aneurysm rupture in AD.
Apiaceae FNS I originated from F3H through tandem gene duplication
Authors: Pucker Boas , Iorizzo Massimo 
Published: January 2023

Background
Flavonoids are specialized metabolites with numerous biological functions in stress response and reproduction of plants. Flavones are one subgroup that is produced by the flavone synthase (FNS). Two distinct enzyme families evolved that can catalyze the biosynthesis of flavones. While the membrane-bound FNS II is widely distributed in seed plants, one lineage of soluble FNS I appeared to be unique to Apiaceae species.

Results
We show through phylogenetic and comparative genomic analyses that Apiaceae FNS I evolved through tandem gene duplication of flavanone 3-hydroxylase (F3H) followed by neofunctionalization. Currently available datasets suggest that this event happened within the Apiaceae in a common ancestor of Daucus carota and Apium graveolens. The results also support previous findings that FNS I in the Apiaceae evolved independent of FNS I in other plant species.

Conclusion
We validated a long standing hypothesis about the evolution of Apiaceae FNS I and predicted the phylogenetic position of this event. Our results explain how an Apiaceae-specific FNS I lineage evolved and confirm independence from other FNS I lineages reported in non-Apiaceae species.