bluuebunny/crossref_metadata_2025_split huggingface dataset:
التّناصُّ المَرئيُّ لقضية التّطبيعِ مع إسرائيل في المَواِقعِ الإلكترونيّةِ للقَنواتِ الفَضائيّةِ المُوجّهةِ
Authors: جواد أيمن كامل 
Published: April 2023

يهدف البحث الى الكشف عن أساليب التناص المرئي المستعملة في المواقع الإلكترونيةِ للقنوات الفضائية الموجّهة باللغة العربية لقضية التطبيع مع «إسرائيل»، وبيان مصادر الصور المُتناصة وانواعها فضلا عن الآلياتِ المنهجية والسيميائية لتحليل تناصّ الصورِ الإخبارية المستعملة في موقعِ قناة «الحرة» للمدة من ١/٦-٣٠/٨/٢٠٢٢، التي تضمنت (٩٤) صورةً، اعتمد منها الباحث (٣٧) صورةً ذاتَ أبعاد تناصية، مستبعدًا (٥٧) صورة، لم تَحمل دَلالاتٍ تتوافق مع مدخلات وأهداف البحث.وقد توصل البحث الى نتائج اهمها:1 - اعتماد موقع قناة «الحرة» على التناص المرئي لقضية التطبيع على النحو الذي يتناسب مع اجنداتها اذ اعتمدت القناة على التناص مع بعض الصور المنشورة في مواقع متعددة لربط الصور وتأطيرها بمعنًى معينٍ لدى الجمهور بغية ترسيخِها في الذهن، فضلا عن انها حاولت تغييرِ المعنى الذي جسدته بعضُ الصورِ إلى دَلالاتٍ تنسجمُ مع أُطروحاتها.
2- واظهرت النتائج تعدد أساليب توظيف التناص المرئي بما ينسجمُ مع مقاصد القناة نحو التطبيعِ مع «إسرائيل»؛ إذ جاء في مقدمتها أسلوبُ التضافر والمحاكاة، ثم جاء أسلوب التشويش وأسلوب القطع في المرتبة الثانية، بعدها أسلوب التحريف، وأخيرًا أسلوب القلب أو العكس. كما أثبتت النتائجُ أن موقعَ قناة «الحرة» وازَن في استعمال الصورِ الشخصية والموضوعيةِ بنسبٍ متقاربة مع موادِّه الإخباريةِ، وبما يتوافقُ مع طبيعةِ الأحداثِ الخاصة بالقضية.

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Nitrogen use efficiency and yield of BRRI dhan46 as influenced by deep placement of N fertilizers under flooded condition
Authors: Islam Md Rafiqul , Tabassum Nazia , Akhter Mst. Tazmin , Hossen Kawsar , Hossain Md Anwar 
Published: April 2023

An experiment was conducted at the Soil Science Field Laboratory of Bangladesh Agricultural University, Mymensingh during aman season of 2015 to evaluate the effect of deep placement of N fertilizers on nitrogen use efficiency and yield of BRRI dhan46 under flooded condition. The soil was silt loam in texture having pH 6.27, organic matter content 1.95%, total N 0.14%, available P 3.16 ppm, exchangeable K 0.09 me% and available S 10.5 ppm. The experiment was laid out in a randomized complete block design with three replications. There were eight treatment combinations including T1 (Control), T2 (PU, 104kgN/ha), T3 (USG, 104kgN/ha), T4 (USG, 78kg N/ha), T5 (USG, 52kg N/ha), T6 (NPK briquette, 104kgN/ha) and T7 (NPK briquette, 78kg N/ha) and T8 (NPK briquette, 52kg N/ha). All the treatments except T6, T7 and T8 received 20 kg P and 50 kg K/ha as TSP and MoP, respectively. Treatments T6, T7, T8 received NPK briquettes fertilizer. Prilled urea was applied in three equal splits. USG and NPK briquettes were applied at 10 DAT and the briquettes were placed at 8-10 cm depth in the center of four hills in alternate rows. The yield attributes, and grain and straw yields of BRRI dhan46 responded significantly to the application of PU, USG and NPK briquettes under flooded condition. The highest yields of grain (5828 kg/ha) and straw (6116 kg/ha) were recorded in T3 and the lowest values of grain and straw yields (3522 and 3783 kg/ha, respectively) were found in the control. Deep placement of N fertilizers also enhanced the N use efficiency, N uptake and apparent recovery by BRRI dhan46. The maximum N use efficiency (22.17 kg grain increase per kg N applied) was found in T3 and the minimum value (9.31 kg grain increase per kg N applied) was recorded in T8. The results reveal that the deep placement of USG (104 kg N/ha) accelerated the N uptake, N recovery and N use efficiency by BRRI dhan46 as compared to other treatments. Therefore, application of 104 kg N/ha as USG may be recommended for profitable cultivation of aman rice, BRRI dhan46.
Asian Australas. J. Biosci. Biotechnol. 2017, 2 (3), 219-225
Utility of Quality by Design approach in RP-HPLC method development for quantification of lamivudine and effavirenz in combination formulation
Authors: KOPPİSETTY Bhagavan Rajesh Babu , PRASAD Prof. Y. Rajendra , AMGOTH Krishna Manjari Pawar , YARRAGUNTLA Srinivasa Rao , DADI Vasudha , TATAPUDI Hemant Kumar 
Published: April 2023

Objective: For the measurement of lamivudine(LAM) and effavirenz (EVZ) in combination formulation, a uncomplicated and reliable liquid chromatographic approach has been proposed.
Material and Method: Multivariate optimization of the RP-HPLC method, experimental conditions were accomplished using the design of experiments (DoE). The crucial method parameters were determined by a risk assessment. The mathematical models were created using three independent variables: percentage of acetonitrile, percentage of methanol, and buffer pH. The impacts of these independent elements were thoroughly investigated using the central composite design (CCD), which was utilized to analyze the response surface methodology.
Result and Discussion: The LAM and EVZ retention time and resolution were both concurrently optimized using the desirability function. Acetonitrile, methanol, and phosphate buffer (pH 7.0) in the proportions of 40:20:40 v/v each were used in the optimized and anticipated data from the contour diagram, with detection occurring at a wavelength of 215 nm. Baseline separation of both pharmaceuticals with high resolution and a run time of under 6 minutes was accomplished under these ideal conditions. The validated test parameters followed ICH recommendations. As a consequence, the findings demonstrated that the Quality by Design methodology could be successfully used to optimize the RP-HPLC technique for the concurrent quantification of LAM and EVZ.
Prevalence and molecular characteristics of polymyxin-resistant Enterobacterales in a Chinese tertiary teaching hospital
Authors: Xiao Chenlu , Li Xuming , Huang Lianjiang , Cao Huiluo , Han Lizhong , Ni Yuxing , Xia Han , Yang Zhitao 
Published: April 2023

IntroductionPolymyxin-resistant Enterobacterales poses a significant threat to public health globally, but its prevalence and genomic diversity within a sole hospital is less well known. In this study, the prevalence of polymyxin-resistant Enterobacterales in a Chinese teaching hospital was investigated with deciphering of their genetic determinants of drug resistance.MethodsPolymyxin-resistant Enterobacterales isolates identified by matrix-assisted laser desorption were collected in Ruijin Hospital from May to December in 2021. Both the VITEK 2 Compact and broth dilution methods were used to determine polymyxin B (PMB) susceptibility. Polymyxin-resistant isolates were further characterized by molecular typing using PCR, multi-locus sequence typing, and sequencing of the whole genome.ResultsOf the 1,216 isolates collected, 32 (2.6%) across 12 wards were polymyxin-resistant (minimum inhibitory concentration (MIC) range, PMB 4–256 mg/ml, and colistin 4 ≥ 16 mg/ ml). A total of 28 (87.5%) of the polymyxin-resistant isolates had reduced susceptibility to imipenem and meropenem (MIC ≥ 16 mg/ml). Of the 32 patients, 15 patients received PMB treatment and 20 survived before discharge. The phylogenetic tree of these isolates showed they belonged to different clones and had multiple origins. The polymyxin-resistant Klebsiella pneumoniae isolates belonged to ST-11 (85.72%), ST-15 (10.71%), and ST-65 (3.57%), and the polymyxin-resistant Escherichia coli belonged to four different sequence types, namely, ST-69 (25.00%), ST-38 (25.00%), ST-648 (25.00%), and ST-1193 (25.00%). In addition, six mgrB specific mutations (snp_ALT c.323T&gt;C and amino acid change p.Val8Ala) were identified in 15.6% (5/32) of the isolates. mcr-1, a plasmid-mediated polymyxin-resistant gene, was found in three isolates, and non-synonymous mutations including T157P, A246T, G53V, and I44L were also observed.DiscussionIn our study, a low prevalence of polymyxin-resistant Enterobacterales was observed, but these isolates were also identified as multidrug resistant. Therefore, efficient infection control measures should be implemented to prevent the further spread of resistance to last-line polymyxin therapy.
Distinct modes of meltwater drainage and landform development beneath the last Barents Sea ice sheet
Authors: Shackleton Calvin , Patton Henry , Winsborrow Monica , Esteves Mariana , Bjarnadóttir Lilja , Andreassen Karin 
Published: April 2023

The flow of glacial ice is impacted by basal meltwater drainage systems that fluctuate on a continuum from distributed, high-pressure environments to channelized, lower pressure networks. Understanding the long-term development of dominant drainage modes and impacts on ice flow and landform development is a crucial step in predicting palaeo and contemporary ice-mass response to changes in climate. The spatial and temporal scales at which different drainage modes operate are largely unknown, and the geomorphological legacy of subglacial meltwater networks that evolve over a glaciation provide composite records of drainage system development. Here, we use high-resolution bathymetric data from shallow banks in the central Barents Sea to map the geomorphological imprint of meltwater drainage beneath the collapsing marine-based Barents Sea Ice Sheet (BSIS). We observe a succession of distinct meltwater landforms that provide relative timing constraints for subglacial drainage modes, indicating that extensive networks of channelized drainage were in operation during deglaciation. Interlinked basins and channels suggest that meltwater availability and drainage system development was influenced by filling and draining cycles in subglacial lakes. Networks of eskers also indicate near-margin meltwater conduits incised into basal ice during late-stage deglaciation, and we suggest that these systems were supplemented by increased inputs from supraglacial melting. The abundance of meltwater during the late stages of BSIS deglaciation likely contributed to elevated erosion of the sedimentary substrate and the mobilisation of subglacial sediments, providing a sediment source for the relatively abundant eskers found deposited across bank areas. A newly discovered beaded esker system over 67 km long in Hopendjupet constrains a fluctuating, but generally decelerating, pace of ice retreat from ∼1,600 m a−1 to ∼620 m a−1 over central Barents Sea bank areas during a 91-year timespan.
How to develop four competencies for teacher educators
Authors: Nguyen Ngan Thi Lan 
Published: April 2023

Understanding competencies and the process of acquiring them contributes to a shared set of essential abilities for teacher educators’ professional development. Practical experiences of practitioners expose which competencies the work context requires them to possess and situations in which their learning is conducted. The necessity for essential contextual competency is pressing, particularly for teacher educators working in developing countries where teacher education has undergone reforms to respond to national and international demands.This study explores competencies for teacher educators in Vietnam through in-depth interviews with experienced practitioners and their visual metaphors. Eight participants with working experience ranging from 6 to 26 years were interviewed for 60–180 min during January–April 2021.The results reveal four competency areas of (1) knowledge and skills consisting of (a) teaching skill, (b) subject content, (c) scientific and subject-related information, (d) the reality of education and multidisciplinary knowledge, (e) research procedural knowledge, (f) collaboration with others, and (g) English language; (2) ethical manner; (3) motivation; and (4) self-reflection about personal values. Professional development includes learning from and working with others, learning in organized courses, conducting independent and collaborative research, and other field-related academic activities. An interesting highlight is that even motivational competency is gradually formed by professionals’ effort put into work.The findings suggest these four competency components should be attended to when providing professional development activities for teacher educators. Motivational competency should be prioritized since it fosters job productivity and commitment. The findings also serve as practical guidance for self-preparation and development for those working as teacher educators in demanding contexts.
Identification of bicalutamide resistance-related genes and prognosis prediction in patients with prostate cancer
Authors: Li Yuezheng , Wang Haoyu , Pan Yang , Wang Shangren , Zhang Zhexin , Zhou Hang , Xu Mingming , Liu Xiaoqiang 
Published: April 2023

BackgroundProstate cancer (PCa) is the second most common type of cancer and the fifth leading cause of cancer-related death in men. Androgen deprivation therapy (ADT) has become the first-line therapy for inhibiting PCa progression; however, nearly all patients receiving ADT eventually progress to castrate-resistant prostate cancer. Therefore, this study aimed to identify hub genes related to bicalutamide resistance in PCa and provide new insights into endocrine therapy resistance.MethodsThe data were obtained from public databases. Weighted correlation network analysis was used to identify the gene modules related to bicalutamide resistance, and the relationship between the samples and disease-free survival was analyzed. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed, and hub genes were identified. The LASSO algorithm was used to develop a bicalutamide resistance prognostic model in patients with PCa, which was then verified. Finally, we analyzed the tumor mutational heterogeneity and immune microenvironment in both groups.ResultsTwo drug resistance gene modules were identified. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses revealed that both modules are involved in RNA splicing. The protein–protein interaction network identified 10 hub genes in the brown module LUC7L3, SNRNP70, PRPF3, LUC7L, CLASRP, CLK1, CLK2, U2AF1L4, NXF1, and THOC1) and 13 in the yellow module (PNN, PPWD1, SRRM2, DHX35, DMTF1, SALL4, MTA1, HDAC7, PHC1, ACIN1, HNRNPH1, DDX17, and HDAC6). The prognostic model composed of RNF207, REC8, DFNB59, HOXA2, EPOR, PILRB, LSMEM1, TCIRG1, ABTB1, ZNF276, ZNF540, and DPY19L2 could effectively predict patient prognosis. Genomic analysis revealed that the high- and low-risk groups had different mutation maps. Immune infiltration analysis showed a statistically significant difference in immune infiltration between the high- and low-risk groups, and that the high-risk group may benefit from immunotherapy.ConclusionIn this study, bicalutamide resistance genes and hub genes were identified in PCa, a risk model for predicting the prognosis of patients with PCa was constructed, and the tumor mutation heterogeneity and immune infiltration in high- and low-risk groups were analyzed. These findings offer new insights into ADT resistance targets and prognostic prediction in patients with PCa.
A novel anatomy-based five-settlement method for endoscopic thyroid lobectomy and ipsilateral central compartment neck dissection via gasless unilateral axillary approach: a preliminary report
Authors: Ge Jun-Na , Yu Shi-Tong , Sun Bai-Hui , Wei Zhi-Gang , Zhang Zhi-Cheng , Chen Wei-Sheng , Li Ting-Ting , Lei Shang-Tong 
Published: April 2023

BackgroundEndoscopic thyroidectomy (ET) via gasless unilateral axillary (GUA) approach has been widely implemented worldwide. Based on our concept of mesothyroid excision in open surgery, we proposed a novel anatomy-based five-settlement method in ET via the GUA approach. This preliminary report aimed to explore the efficacy and safety of this method in patients with papillary thyroid carcinoma (PTC).MethodsPTC patients who underwent endoscopic ET and unilateral central compartment neck dissection (CCND) via GUA approach with the five-settlement method at the Department of General Surgery, Nanfang Hospital, Southern Medical University from March 2020 to December 2021 were retrospectively collected. The data included general clinicopathological characteristics, surgical information (including duration, complication, and clinicopathological features), and hospital stay information, and other medical records were documented.ResultsIn total, 521 patients underwent lobectomy and CCND under the GUA approach with the five-settlement method. The mean number of lymph nodes yielded (LNY) and positive lymph nodes (PLN) was 5.7 ± 4.3 (range, 1–30) and 1.0 ± 1.8 (range, 0–12), respectively. The incidence of transient recurrent laryngeal nerve injury was 1.1%. Chyle leakage and Horner’s syndrome respectively occurred in one patient (0.2%). Five (0.9%) patients developed a hematoma. No severe complications or conversion to open surgery have occurred.ConclusionThe five-settlement method could be implemented safely and efficiently in ET+CCND via the GUA approach in selected PTC patients.
Case report: Two individuals with AEBP1-related classical-like EDS: Further clinical characterisation and description of novel AEBP1 variants
Authors: Angwin Chloe , Ghali Neeti , van Dijk Fleur Stephanie 
Published: April 2023

Introduction:AEBP1-related classical-like EDS (clEDS type 2) is a rare type of Ehlers–Danlos syndrome (EDS) that was first reported in 2016. There are overlapping clinical features with TNXB-related classical-like EDS (or clEDS type 1), including skin hyperextensibility, joint hypermobility, and easy bruising. There are currently nine reported individuals with AEBP1-related clEDS type 2. This report confirms previous findings and provides additional clinical and molecular data on this group of individuals.Materials and methods: Two individuals (P1 and P2), with features of a rare type of EDS, were clinically assessed in the London national EDS service and underwent genetic testing.Results: Genetic testing in P1 revealed likely pathogenic AEBP1 variants: c.821del:p. (Pro274Leufs*18) and c.2248T&gt;C:p. (Trp750Arg). In P2 pathogenic AEBP1 variants, c.1012G&gt;T:p. (Glu338*) and c.1930C&gt;T:p. (Arg644*) were identified.Discussion: These two individuals increased the reported number of individuals with AEBP1-related clEDS to 11 (six females and five males). There are shared features with previously reported individuals, including hypermobility (11/11), skin hyperextensibility (11/11), presence of atrophic scarring (9/11), and easy bruising (10/11). In P1, a chronic right vertebral artery dissection, mild dilatation of the splenic artery, aberrant subclavian artery, and tortuous iliac arteries were observed at the age of 63 years. Cardiovascular disease has been reported, including mitral valve prolapse (4/11), peripheral arterial disease (1/11), and aortic root aneurysm requiring surgical intervention (1/11). Hair loss has been reported in 6/11 individuals (five females and one male), only one of which was documented to have a formal diagnosis of androgenetic alopecia, while other individuals were described as having thinning of hair, male pattern hair loss, or unspecified alopecia.Conclusion: The clinical features of individuals with AEBP1-related EDS have not been fully elucidated yet. Hair loss is present in 6/11 individuals with AEBP1-related clEDS and appears to be a feature of this condition. This is the first time hair loss has been formally reported as a characteristic feature in a rare type of EDS. Cardiovascular surveillance seems warranted in this condition because 2/11 individuals have evidence of arterial aneurysm and/or dissection. Further descriptions of affected individuals are necessary to update diagnostic criteria and management guidelines.
Comparative transcriptomics identifies the key in planta-expressed genes of Fusarium graminearum during infection of wheat varieties
Authors: Tu Qiang , Wang Lirong , An Qi , Shuai Jie , Xia Xiaobo , Dong Yifan , Zhang Xu , Li Gang , He Yi 
Published: April 2023

Fusarium head blight (FHB), caused mainly by the fungus Fusarium graminearum, is one of the most devastating diseases in wheat, which reduces the yield and quality of grain. Fusarium graminearum infection of wheat cells triggers dynamic changes of gene expression in both F. graminearum and wheat, leading to molecular interactions between pathogen and host. The wheat plant in turn activates immune signaling or host defense pathways against FHB. However, the mechanisms by which F. graminearum infects wheat varieties with different levels of host resistance are largely limited. In this study, we conducted a comparative analysis of the F. graminearum transcriptome in planta during the infection of susceptible and resistant wheat varieties at three timepoints. A total of 6,106 F. graminearum genes including those functioning in cell wall degradation, synthesis of secondary metabolites, virulence, and pathogenicity were identified during the infection of different hosts, which were regulated by hosts with different genetic backgrounds. Genes enriched with metabolism of host cell wall components and defense response processes were specifically dynamic during the infection with different hosts. Our study also identified F. graminearum genes that were specifically suppressed by signals derived from the resistant plant host. These genes may represent direct targets of the plant defense against infection by this fungus. Briefly, we generated databases of in planta-expressed genes of F. graminearum during infection of two different FHB resistance level wheat varieties, highlighted their dynamic expression patterns and functions of virulence, invasion, defense response, metabolism, and effector signaling, providing valuable insight into the interactions between F. graminearum and susceptible/resistant wheat varieties.