bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serositis and lymphopenia are common features of systemic lupus erythematosus following SARS‐CoV‐2 infection: A case report and literature review
Authors: Kioi Yoshiyuki , Yorifuji Hideki , Higami Yuichi , Katada Yoshinori 
Published: June 2023

AbstractThe coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can affect a number of human systems, including the respiratory, cardiovascular, neurological, gastrointestinal, and musculoskeletal systems. These symptoms persist long after the acute infection has healed and is called “long COVID”. Interestingly, there have been a series of reports that SARS‐CoV‐2 infections trigger the development of various autoimmune diseases such as systemic lupus erythematosus (SLE), inflammatory arthritis, myositis, vasculitis. Here, we report a novel case of SLE characterized by persistent pleural effusion and lymphopenia following SARS‐CoV‐2 infection. This is the first case in the Western Pacific region to our knowledge. Furthermore, we reviewed 10 similar cases including our case. By looking at the characteristics of each case, we found that serositis and lymphopenia are common features of SLE following SARS‐CoV‐2 infection. Our finding suggests that patients with prolonged pleural effusion and/or lymphopenia after COVID‐19 should be checked for autoantibodies.
Impacts of COVID‐19 on Women and/or Caregivers in Accounting Academia at Canadian Postsecondary Institutions and Suggestions Moving Forward: A Commentary*
Authors: McLachlan Lindsay 
Published: June 2023

ABSTRACTThis commentary provides insights on the issues faced by women and/or caregivers in accounting academia at Canadian postsecondary institutions during the COVID‐19 pandemic. Personal reflections from 23 contributors across Canada were compiled and analyzed using thematic content analysis. Results show that COVID‐19 has adversely impacted research, teaching, and other areas of work and life for this demographic. Research stopped or slowed, lower productivity was experienced, concerns over academic integrity increased, interactions with students decreased, academics left the profession, mental health was adversely impacted, and academics lost dedicated work time. In addition, the contributors provide suggestions to address these issues moving forward to help equity‐seeking groups. Suggestions include support from postsecondary institutions at all levels, additional funding, adjustments to tenure and promotion criteria, and the option for a reduced workload.
Implementation of an algorithm for tapering analgosedation reduces iatrogenic withdrawal syndrome in pediatric intensive care
Authors: Dokken Mette , Rustøen Tone , Diep Lien My , Fagermoen Frode Even , Huse Rakel Iren , Egerod Ingrid , Bentsen Gunnar Kristoffer 
Published: June 2023

AbstractBackgroundProper analgosedation is a cornerstone in the treatment of critically ill patients in Pediatric Intensive Care Units (PICUs). Medications, such as fentanyl, morphine, and midazolam, are essential to safe and respectful care. The use of these medications over time may lead to side effects such as iatrogenic withdrawal syndrome (IWS) in the tapering phase. The aim of the study was to test an algorithm for tapering analgosedation to reduce the prevalence of IWS in two Norwegian PICUs at Oslo University Hospital.MethodsA cohort of mechanically ventilated patients from newborn to 18 years with continuous infusions of opioids and benzodiazepines for 5 days or more were included consecutively from May 2016 to December 2021. A pre‐ and posttest design, with an intervention phase using an algorithm for tapering analgosedation after the pretest, was used. The ICU staffs were trained in using the algorithm after the pretest. The primary outcome was a reduction in IWS. The Withdrawal Assessment Tool‐1 (WAT‐1) was used to identify IWS. A WAT‐1 score ≥3 indicates IWS.ResultsWe included 80 children, 40 in the baseline group, and 40 in the intervention group. Age and diagnosis did not differ between the groups. The prevalence of IWS was 95% versus 52.5% in the baseline group versus the intervention group, and the peak WAT‐1 median was 5.0 (IQR 4–6.8) versus 3.0 (IQR 2.0–6.0) (p = .012). Based on SUM WAT‐1 ≥ 3, which describes the burden over time better, we demonstrated a reduction of IWS, from a median of 15.5 (IQR 8.25–39) to a median of 3 (IQR 0–20) (p = <.001).ConclusionWe suggest using an algorithm for tapering analgosedation in PICUs since the prevalence of IWS was significantly lower in the intervention group in our study.
Effect of multidisciplinary treatment (MDT) on survival outcomes of lung cancer patients: Experiences from China
Authors: Jing Xiao‐mei , Chen Ping , Li Si‐feng , Feng Zi‐rui , Li Yin‐feng , Yang Qing 
Published: June 2023

AbstractAimTo evaluate the effect of multidisciplinary treatment (MDT) on the survival outcomes of Chinese lung cancer patients.MethodsData from a Chinese tertiary cancer hospital of lung cancer patients were collected and divided into two groups (MDT+/−) according to whether the patients had received an MDT. The survival analysis was performed after propensity score matching (PSM).ResultsBefore PSM, more patients in the MDT+ group had documented information on clinical characteristics and showed more unfavorable clinical characteristics than patients in the MDT− group. After PSM, there was no imbalance in the first‐line treatment strategies between the two groups. When the patients were analyzed separately, for patients in the MDT− group, age at diagnosis, Eastern Cooperative Oncology Group (ECOG) score, stage, smoking history, and epidermal growth factor receptor (EGFR) gene status were all significant factors for survival (p < 0.05). For patients in the MDT+ group, only age at diagnosis, stage, and comorbidities were significant factors for survival (p < 0.05). Moreover, age at diagnosis, ECOG score, stage, EGFR gene status, and MDT were all significant factors for survival for all patients (p < 0.001). The results indicate that MDT was a significant prognostic factor independent of clinical characteristics (HR: 2.095, 95% CI: 1.568–2.800, p < 0.001), with a significantly improved median survival (58.0 vs. 29.0 months, p < 0.001).ConclusionBased on PSM, MDT itself did have a real favorable prognostic significance for Chinese lung cancer patients in the study.
Barriers to obesity health care in general practice from rural Waikato GP perspectives: A qualitative study
Authors: Norman Kimberley , Burrows Lisette , Chepulis Lynne , Lawrenson Ross 
Published: June 2023

AbstractObjectiveOver 34% of New Zealand (NZ) adults are classed as obese, which reduces quality of life for many individuals. Those living in rural areas, high‐deprivation communities, and indigenous Māori populations are more likely to experience obesity and related co‐morbidities than other cohorts. General practice is positioned as most suitable to deliver effective weight management health care; however, little is understood about the rural general practitioner (GP) experience in NZ, despite having the majority of patients at high risk of developing obesity. The aim of this study was to investigate rural GP perspectives on barriers to delivering weight management.DesignQualitative descriptive design guided by Braun and Clarke (2006) using semi‐structured interviews and analysed using deductive reflexive thematic approach.SettingRural Waikato general practice which has significant rural, Māori and high‐deprivation communities.ParticipantsSix rural Waikato GPs.ResultsThree significant themes were identified: communication barriers, rural health care barriers, and social and cultural barriers. GPs reported not wanting to jeopardise the doctor‐patient relationship by discussing weight. GPs felt unsupported by the health system through lack of rurally appropriate obesity intervention options, funding and resources. The unique rural lifestyle and health needs were reportedly not understood at the wider health system level, making the role of a rural GP working in high‐deprivation communities more difficult. Additional barriers to delivering effective weight management included factors outside the clinical practice such as obesity stigma, an obesogenic environment and sociocultural factors shaping rural patients' lives.ConclusionRural GPs have a lack of weight management referral options that are considered effective for their patients, as the options available reportedly do not cater for their patients' unique rural health needs. GPs position addressing the individualised and complex weight management health issue as challenging. Navigating stigma, wider sociocultural issues, and limited intervention options were difficult and found to be questionable to achieve in a short 15‐min consult. There is a need for rural health support in the form of funding, staff (indigenous and non‐indigenous), and rurally feasible resources to improve health outcomes and reduce inequity. Effective primary care weight management strategies need to be appropriate for high‐deprivation rural communities, including tailored, affordable and reliable interventions that GPs can offer patients if future weight management efforts are to be successful in this space.
Early detection of disease onset through changes in appearance of pre‐weaning calves
Authors: Shingu Yuko , Dokoshi Akira , Ueda Koichiro 
Published: June 2023

AbstractThe onset of diseases in pre‐weaning calves can lead to changes in their appearance, which can aid early disease detection. This study measured the changes in appearance that led to disease onset in 66 pre‐weaning Holstein calves. The appearance scores of the calves were recorded for 7 days before the onset of digestive or respiratory diseases. Appearance features (ear position, head position, topline curve, hair coat length, hair coat gloss, eye opening, and sunken eyes) were recorded using video camera images and scored from 0 (healthy) to 2 (poor). Among the calves with respiratory diseases, the proportion of calves with a score of 0 for ear position decreased linearly over time (p = 0.0437). Among the calves with digestive diseases, the proportion of calves with a score of 2 for hair coat length increased linearly over time (p = 0.0197). Among the calves with both respiratory and digestive diseases, the proportion of calves with scores of 1 for the topline curve and 2 for eye opening increased linearly over time (p = 0.0191). Therefore, early signs of disease manifest as different appearance features depending on the type of disease before its onset.
On a remarkable sexual dimorphic trait on scales and fins of the old world Cyprinodontiformes (Actinopterygii: Aphaniidae)
Authors: Esmaeili Hamid Reza , Echreshavi Sorour , Masoumi Amir Hassan , Nejad Abbas Motlagh 
Published: June 2023

AbstractSecondary sexual dimorphism is an interesting and stupendous subject of research study due to the fact that it is a result of sexual selection, mostly attributed to either female mate choice or male–male competition. This study aims to investigate the microscopic characterization of scales and fin rays in several aphaniids (Cyprinodontiformes: Aphaniidae) to find out the possibility of using these structures as secondary sexual dimorphism traits and discuss their taxonomic and evolutionary significance. Herein, the results reveal that (i) male individuals of aphaniid species of the genera Aphanius, Aphaniops and Paraphanius present contact organs in the forms of ctenus‐like structure (in posterior margin of the scales) and spicule‐like structure (in anal fin rays) that show sexual dimorphism of scales and fins; (ii) number, position, size and shape of contact organs provide taxonomic signal to distinguish members of the genus Aphaniops from two other genera; (iii) females of Aphaniops ginaonis also represent contact organs in scales but fewer than males and (iv) as the sexual dimorphism results from different sexual selection pressures acting on males and females, it provides evolutionary signals.
Gametogenesis in Rhinella bergi (Anura: Bufonidae): Morphological and morphometric analysis
Authors: Cheij Esteban , Olea Gabriela Beatriz , Rodríguez Florencia , Céspedez Jorge , Flores Quintana Carolina 
Published: June 2023

AbstractThis study aims to characterize the gonads, folliculogenesis, and spermatogenesis processes of male and female Rhinella bergi through anatomical, histological and morphometric analysis. We worked with specimens previously collected in the spring and summer seasons (2014–2015), in which the gonads were studied based on morphological, histological and morphometric analysis. The reproductive system was analyzed using a stereoscopic microscope and a scanning electron microscope (SEM). Histological preparations were made following the conventional protocol of dehydration, inclusion in paraffin and stained with haematoxylin–eosin, Mallory trichrome and PAS histochemical reactions. The anatomical and morphometric characteristics and the gametogenesis in R. bergi agree with what was proposed for other analyzed species of the Bufonidae family. Females with ovaries with oocytes in different stages of maturity and postovulatory females were found. The males presented continuous spermatogenesis. The results of this work serve as a basis for the characterization of the reproductive cycle in R. bergi and, at the same time, provide background information on the analysis of gametogenic activity. Future investigations will be focused on evaluating the reproductive cycle in this species, both in ovaries and testes as well as Bidder's organ, to compare and correlate with the results obtained in this study.
Shake it off! Adaptive coping with stress reduces national narcissism
Authors: Molenda Zuzanna , Marchlewska Marta , Rogoza Marta , Szczepańska Dagmara 
Published: June 2023

AbstractExamining the role of coping with stress strategies in shaping national narcissism, we proposed that this type of defensive national commitment (stemming from psychological shortcomings) should be lowered by adaptive coping strategies. In Study 1 (longitudinal, N = 603), we found that higher adaptive (i.e. self‐sufficient) coping attenuated national narcissism. In Study 2 (experimental, N = 337), the priming of adaptive coping significantly decreased national narcissism. We also demonstrated the indirect effects of the induced adaptive coping strategy on conspiracy beliefs via national narcissism. These findings suggest that using adaptive coping strategies (either dispositional or situationally induced) may attenuate national narcissism. We discuss the role of coping with stress in shaping group‐level phenomena.
Guidance to best tools and practices for systematic reviews
Authors: Kolaski Kat , Logan Lynne Romeiser , Ioannidis John P. A. 
Published: June 2023

Data continue to accumulate indicating that many systematic reviews are methodologically flawed, biased, redundant, or uninformative. Some improvements have occurred in recent years based on empirical methods research and standardization of appraisal tools; however, many authors do not routinely or consistently apply these updated methods. In addition, guideline developers, peer reviewers, and journal editors often disregard current methodological standards. Although extensively acknowledged and explored in the methodological literature, most clinicians seem unaware of these issues and may automatically accept evidence syntheses (and clinical practice guidelines based on their conclusions) as trustworthy.A plethora of methods and tools are recommended for the development and evaluation of evidence syntheses. It is important to understand what these are intended to do (and cannot do) and how they can be utilized. Our objective is to distill this sprawling information into a format that is understandable and readily accessible to authors, peer reviewers, and editors. In doing so, we aim to promote appreciation and understanding of the demanding science of evidence synthesis among stakeholders. We focus on well‐documented deficiencies in key components of evidence syntheses to elucidate the rationale for current standards. The constructs underlying the tools developed to assess reporting, risk of bias, and methodological quality of evidence syntheses are distinguished from those involved in determining overall certainty of a body of evidence. Another important distinction is made between those tools used by authors to develop their syntheses as opposed to those used to ultimately judge their work.Exemplar methods and research practices are described, complemented by novel pragmatic strategies to improve evidence syntheses. The latter include preferred terminology and a scheme to characterize types of research evidence. We organize best practice resources in a Concise Guide that can be widely adopted and adapted for routine implementation by authors and journals. Appropriate, informed use of these is encouraged, but we caution against their superficial application and emphasize their endorsement does not substitute for in‐depth methodological training. By highlighting best practices with their rationale, we hope this guidance will inspire further evolution of methods and tools that can advance the field.
Late Jurassic rift physiography of the Froan Basin and Frøya High, offshore Mid‐Norway: Development of a syn‐rift shallow marine system
Authors: Nakken Lise , Chiarella Domenico , Jackson Christopher A‐L. 
Published: June 2023

AbstractThe Froan Basin and Frøya High are two major structural elements located on the Mid‐Norwegian Continental Shelf and are separated from the Halten Terrace by major west‐dipping normal fault zones. Compared to the Halten Terrace, the Froan Basin and Frøya High are relatively under‐explored and remain poorly understood in terms of their Late Jurassic tectono‐stratigraphic evolution. Upper Jurassic, shallow marine, syn‐rift deposits (i.e. Rogn Formation) are present locally, but their source, delivery system and depositional environment are not yet well understood. Improving our understanding of how fault activity and rift‐shoulder uplift influenced rift physiography and paleowater depths is crucial when developing depositional models in this region. In this study, we present a model of the Late Jurassic rift physiography of the Froan Basin and Frøya High based on seismic reflection and well data and reverse subsidence modelling. We show that during the Late Jurassic to Early Cretaceous, major footwall uplift caused the Frøya High and the western margin of the central Froan Basin to be subaerially exposed, forming an intra‐rift footwall island. Shallow marine areas to the east, immediately adjacent to the footwall island, accumulated sediment supplied from the uplifted and partially eroded footwall. In contrast, the Trøndelag Platform, north of the Froan Basin and Frøya High, remained submerged throughout the rift episode. We therefore suggest that the extent of the shallow marine system was controlled by the magnitude of footwall uplift along the western margin of the basin and that sediment dispersal was influenced by the coastal paleogeomorphology of the back‐tilted footwall.
Synthetic approaches and applications of an underprivileged 1,2,5‐oxadiazole moiety: A review
Authors: Kumar Greesh , Kumar Rajnish , Mazumder Avijit , Salahuddin  , Kumar Upendra 
Published: June 2023

Abstract1,2,5‐oxadiazole belongs to five‐membered heterocyclic compounds with two nitrogen and one oxygen atom. In comparison with other heterocyclic moieties, 1,2,5‐oxadiazoles moiety is considered as underprivileged as it attracted little attention of the researchers although lot of scopes and possible applications in medicinal, material and agriculture science. 1,2,5‐oxadiazole and its derivatives have been reported as good pharmacophores as carbonic anhydrase inhibitors, antibacterial, vasodilating agents, antimalarial, anticancer, etc. In the presented manuscript, we reviewed granted patents and different synthetic strategies which have been reported for the synthesis of 1,2,5‐oxadiazoles such as cycloaddition, dimerization, cyclodehydration, condensation, thermolysis, nitration, oxidation and ring‐conversion. These synthetic methods have also been analysed for their merits and demerits. The manuscript also highlighted various applications of 1,2,5‐oxadiazole and its derivatives. We hope that researchers across the scientific streams will be benefitted from the presented review articles for designing their work related to 1,2,5‐oxadiazoles.
Instability of harmonized thyroid‐stimulating hormone immunoassays in clinical practice
Authors: Uto Kenichi , Bando Hironori , Fukuoka Hidenori , Yamamoto Masaaki , Ogasahara Ayako , Ono Shoko , Oyabu Chinami , Sato Itsuko , Imanishi Takamitsu , Saegusa Jun , Ogawa Wataru , Yano Yoshihiko 
Published: June 2023

AbstractObjectiveThyroid‐stimulating hormone (TSH) harmonization is effective in minimizing differences between the results of immunoassays in healthy subjects. However, the effectiveness of TSH harmonization in clinical practice has not been investigated. The aim of this study was to evaluate the instability of TSH harmonization in clinical practice.MethodsWe compared the reactivities of four harmonized TSH immunoassays using combined difference plots of 431 patients. We selected patients with statistically significant deviations in TSH levels and analyzed their thyroid hormone levels and clinical characteristics.ResultsThe combined difference plots showed that one harmonized TSH immunoassay exhibited markedly different reactivity even after TSH harmonization compared with the other three immunoassays. Among 109 patients with mild‐to‐moderate elevation of TSH levels, we selected 15 patients with statistically significant deviations in TSH levels according to the difference plots of three harmonized TSH immunoassays, excluding one immunoassay that showed different reactivity. The thyroid hormone levels of three patients were misclassified as hypothyroidism or normal due to deviating TSH levels. In terms of clinical characteristics, these patients were in poor nutritional status and general condition, possibly due to their severe illness (e.g., advanced metastatic cancer).ConclusionWe have confirmed that TSH harmonization in clinical practice is relatively stable. However, some patients showed deviating TSH levels in the harmonized TSH immunoassays, indicating the need for caution, particularly in poorly nourished patients. This finding suggests the presence of factors that contribute to the instability of TSH harmonization in such cases. Further investigation is warranted to validate these results.
Exploring the effect of kin caregivers' family functioning on child survival in South Africa: An application of the Family Systems Theory
Authors: Mabetha Khuthala , De Wet‐Billings Nicole C. , Odimegwu Clifford O. 
Published: June 2023

AbstractThe survival of children who are raised in kinship care is largely influenced by the way their primary caregivers manage their family dynamics. Although research has focused on the effects of family structure and other extended kin effects on various child health outcomes, it remains largely unknown how kin caregivers' family functioning influences child survival, particularly in the South African context where the practice of kinship care is widely spread. An inductive thematic approach was employed, and data were collected from 24 kin caregivers who were providing care to under‐five children. Analysis of the data resulted in the development of three superordinate themes, namely, (1) relationship with family members, (2) poor relationships and (3) family attachment and communication. Each superordinate theme was linked to subthemes that helped explain the phenomenon under study. Overall, the kin caregivers' family environments serve as both protective barriers and risk factors for child survival depending on the state of familial relationships, collaboration and involvement of other kin within the households of primary kin caregivers. This translates into the survival of children being greatly determined by the family environment in which they live and the quality of care that they receive in that family environment.