bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of Oct‐4 transcription factor as a pivotal therapeutic target for CD44+/24− mammary tumor initiating cells: Aiming at the root of the recurrence
Authors: Sen Utsav , Shanavas Shanooja , Nagendra Apoorva H. , Nihad Muhammad , Chaudhury Debajit , Rachamalla Hari K. , Banerjee Rajkumar , Shenoy P Sudheer , Bose Bipasha 
Published: December 2022

AbstractBreast cancer (BC) remains one of the deadliest and frequently diagnosed metastatic cancers worldwide. Cancer stem cells (CSCs) are the cell population within the tumor niche, having an epithelial to mesenchymal (EMT) transition phenotype, high self‐renewal, vigorous metastatic capacity, drug resistance, and tumor relapse. Identification of targets for induction of apoptosis is essential to provide novel therapeutic approaches in BC. Our earlier studies showed that Vitamin C induces apoptotic cell death by losing redox balance in TNBC CSCs. In this study, we have attempted to identify previously unrecognized CSC survival factors that can be used as druggable targets for bCSCs apoptosis regulators isolated from the TNBC line, MDA MB 468. After a thorough literature review, Oct‐4 was identified as the most promising marker for its unique abundance in cancer and absence in normal cells and the contribution of Oct‐4 to the sustenance of cancer cells. We then validated a very high expression of Oct‐4 in the MDA MB 468 bCSCs population using flow‐cytometry. The loss of Oct‐4 was carried out using small interfering RNA (siRNA)‐mediated knockdown in the bCSCs, followed by assessing for cellular apoptosis. Our results indicated that Oct‐4 knockdown induced cell death, changes in cellular morphology, inhibited mammosphere formation, and positive for Annexin‐V expression, thereby indicating the role of Oct‐4 in bCSC survival. Moreover, our findings also suggest the direct interaction between Oct‐4 and Vitamin C using in silico docking. This data, hence, contributes towards novel information about Oct‐4 highlighting this molecule as a novel survival factor in bCSCs.
A Tunisian patient with CLCN2‐related leukoencephalopathy
Authors: Ben Mohamed Dina , Saied Zacharia , Ben Sassi Samia , Ben Said Mariem , Nabli Fatma , Achouri Afef , Jeridi Cyrine , Masmoudi Saber , Amouri Rim 
Published: December 2022

AbstractCLCN2‐related leukoencephalopathy (CC2L OMIM#: 615651) is a recently identified rare disorder. It is caused by autosomal recessive mutations in the CLCN2 gene and leads to the dysfunction of its encoded CLC‐2 chloride channel protein with characteristic brain MRI features of leukoencephalopathy. We report the first Tunisian patient with clinical features of ClCN‐2‐related leukoencephalopathy. A 54‐year‐old female with a family history of leukemia, male infertility, motor disability, and headaches who initially presented with a tension‐type headache and normal physical examination. At the follow‐up, she developed mild gait ataxia and psycho‐cognitive disturbances. A previously reported homozygous NM_004366.6(CLCN2):c.1709G > A (p.Trp570Ter) stop gained mutation was identified. This report expands the knowledge related to CC2L and highlights the clinical features in affected individuals of African descent.
Ondansetron‐induced pseudoallergy with non‐ischemic myocardial injury: A rare case report of Kounis syndrome
Authors: Firew Eden , Huang Helen , Anand Ayush , Asfaw Yonathan Aliye , Parikh Charmy , Khan Hamza Rafique 
Published: December 2022

AbstractOndansetron is an FDA‐approved selective serotonin 5‐HT3 receptor commonly indicated as an anti‐emetic agent for nausea and vomiting. It is rare to observe fatal reactions from ondansetron despite having no allergies or previous exposure. We report a case of anaphylactoid reaction with spontaneous coronary vasospasms in response to intravenous ondansetron.
Dyspnea after endomedullary nailing: Fat embolism
Authors: Martens Sebastiaan , De Wit Marcia , De Grim Laurens 
Published: December 2022

AbstractFat embolism is a well‐known and life‐threatening condition that can develop after long bone fractures and lower limb orthopedic surgery. It presents in a wide range of respiratory, hematological, neurological, and cutaneous symptoms and signs of varying severity, resulting from embolic showering. It is important for clinicians to have a high index of suspicion for fat embolism in patients with respiratory compromise postoperatively. Rapid recognition and supportive treatment are key in improving the outcome of these patients. The prognosis is usually good, except in fulminant fat embolism syndrome.
Preeclampsia in a pregnant woman with severe aplastic anemia: A case report
Authors: Kawabata Ikuno , Yokote Ryoko , Kasano Sayuri , Ogawa Jun , Kato Masahiko , Ichikawa Tomoko , Yonezawa Mirei , Kuwabara Yoshimitsu , Yamaguchi Hiroki , Suzuki Shunji 
Published: December 2022

AbstractA pregnant woman with severe aplastic anemia was managed using biweekly red blood cell transfusion and oral eltrombopag olamine administration during pregnancy. She was diagnosed with preeclampsia at 35 weeks of gestation. The severity of aplastic anemia is very important for predicting the course of pregnancy.
Cu‐Catalyzed Polychloromethylamination of Styrenes through C(sp3)−H Bond Cleavage
Authors: Zhu Fengxiang , Xue Jianxin , Yin Pengpeng 
Published: December 2022

AbstractA copper‐catalyzed three‐component coupling reaction has been developed allowing the rapid building of valuable complex highly functionalized β‐polychloromethyl amines from simple styrenes, arylamines, and dichloromethane/chloroform. Using aryldiazonium salts as a radical initiator, a series of corresponding products are obtained with moderate to good yields under a carbon dioxide or nitrogen atmosphere (50 psi). In addition, good functional group tolerance can be observed.
The Effect of Mesogenic Coronas on the Type and Anisotropy of Gold Nanoparticle Superlattices: When Can the Tail Wag the Dog?
Authors: Zhao Yang‐yang , Li Yaxin , Cao Yu , Mehl Georg H. , Liu Feng , Ungar Goran 
Published: December 2022

AbstractThe correlation between the size of nanoparticles, the structure and shape of mesogenic ligands and the ensuing assembly behaviour is not really understood. Closer inspection shows very surprising features. Here, 2‐ and 4‐nm gold nanoparticles (NPs) were synthesized, and grafted with a forked ligand containing two rod‐like mesogens in its branches: one cholesterol, the other with azobenzene. The 4‐nm NPs also contained n‐hexylthiol as co‐ligand. They were found to form a FCC cubic superlattice, whereas the 2‐nm NPs form hexagonal HCP with weak birefringence, hence with partially oriented ligands. The structures were compared with those of related systems containing a range of different azobenzene‐to‐cholesterol ratios, all giving body‐centred tetragonal superlattices with various degrees of anisotropy. Geometric analysis is presented in terms of the asphericity of the NPs’ surroundings, requirement for space‐filling and structural anisotropy. Some general rules are derived to help design the soft corona around the NPs in order to obtain superlattices with the desired structure and anisotropy.
Enhancing the Magnetization Blocking Energy of Biradical‐Metal System by Merging Discrete Complexes into One‐Dimensional Chains
Authors: Xie Junfang , Han Jing , Huang Xiaohui , Jin Chaoyi , Li Licun , Sutter Jean‐Pascal 
Published: December 2022

AbstractThe reaction of nitronyl nitroxide biradical NITPhMeImbis [5‐(2‐methylimidazole)‐1,3‐bis(1‐oxyl‐3’‐oxido‐4’,4’,5’,5’‐tetramethyl‐4,5‐hydro‐1H‐imidazol‐2‐yl)‐benzene] with Ln(hfac)3 ⋅ 2H2O and Cu(hfac)2 (hfac=hexafluoroacetylacetonate), led to two series of 2p–3d‐4f complexes, namely, nona‐spin clusters, [Ln2Cu3(hfac)12(NITPhMeImbis)2] (Ln=Gd 1, Dy 2), or one‐dimensional chains [LnCu2(hfac)7(NITPhMeImbis)] (Ln=Y 3, Dy 4, Tb 5) depending on the temperature of the reaction. All five complexes contain a biradical‐Ln unit in which the biradical chelates the LnIII ion by the means of one aminoxyl (i. e. NO) group of each NIT unit. For the discrete complexes, a Cu(hfac)2 links two biradical‐Ln units via one of the remaining NO groups, while for the chain compounds, the two remaining NO groups of the biradical‐Ln moiety are each coordinated to a Cu(hfac)2 unit to form a 1D coordination polymer. Moreover, a terminal Cu(hfac)2 unit is coordinated to the imidazole‐N atom of the NITPhMeImbis ligand. Spin dynamics investigations evidenced the onset of slow relaxation of the magnetization for 2, whereas 4 and 5 exhibit a typical single‐chain magnet behavior. This highlights the vital role of the 1D spin correlation in the blocking of the magnetization. These results illustrate that from the same basic building blocks, magnetic relaxation can be carefully modulated by structural adjustments.
Chromatic Selectivity of Coumarin‐Caged Oligonucleotides
Authors: Kaufmann Janik , Sinsel Fabian , Heckel Alexander 
Published: December 2022

AbstractA system of two coumarin‐based caging groups is presented – one absorbing in the blue (400–450 nm) and the other absorbing in the green (480–550 nm) part of the visible spectrum. Together they form a pair, which allows to selectively photoactivate the one or the other in oligonucleotides. A numerical characterization defining the term “chromatic selectivity” was proposed, and it was shown how chromatically selective uncaging can literally be titrated in a kinetic reaction scheme.
Asymmetric synthesis of the sex pheromone of the apple leafminer, Lyonetia prunifoliella
Authors: Yu Shihang , Yuan Gucheng , Liu Jiawei , Bian Qinghua , Wang Min , Zhong Jiangchun 
Published: December 2022

AbstractLyonetia prunifoliella is a significant pest in orchards and damages apple. The sex pheromones of this pest were prepared via a new and concise method. The central to our method were Evans' chiral auxiliaries, the addition of chiral Grignard reagent to aldehyde and Wittig coupling.
Influence of Nozzle Parameters on Spray Pattern and Droplet Characteristics for a Two‐Fluid Nozzle
Authors: Kramm Kathrin , Orth Maike , Teiwes Arne , Kammerhofer Jana Christina , Meunier Vincent , Pietsch‐Braune Swantje , Heinrich Stefan 
Published: December 2022

AbstractIn this study, a two‐fluid nozzle, as, e.g., used in fluidized‐bed or spray drying applications, is comprehensively characterized regarding the spray pattern and droplet size. To analyze the spray cone, the spray cone angle and the radial mass distribution of the nozzle were measured at varied liquid flow rate, spray air pressure, liquid insert bore diameter, and air cap position. Additionally, droplet size distributions were recorded at different spray settings. In general, the overall spray cone and single droplets are significantly influenced by the spray parameters, especially the spray air pressure, as well as the nozzle geometry.
An inner‐outer subcycling algorithm for parallel cardiac electrophysiology simulations
Authors: Laudenschlager Sebastian , Cai Xiao‐Chuan 
Published: December 2022

AbstractThis paper explores cardiac electrophysiological simulations of the monodomain equations and introduces a novel subcycling time integration algorithm to exploit the structure of the ionic model. The aim of this work is to improve upon the efficiency of parallel cardiac monodomain simulations by using our subcycling algorithm in the computation of the ionic model to handle the local sharp changes of the solution. This will reduce the turnaround time for the simulation of basic cardiac electrical function on both idealized and patient‐specific geometry. Numerical experiments show that the proposed approach is accurate and also has close to linear parallel scalability on a computer with more than 1000 processor cores. Ultimately, the reduction in simulation time can be beneficial in clinical applications, where multiple simulations are often required to tune a model to match clinical measurements.
Environmental performance and financial performance: Empirical evidence from Indonesian companies
Authors: Hanjani Andreani , Kusumadewi Rr. Karlina Aprilia 
Published: December 2022

AbstractThis study aims to investigate the effect of Audit Committee, firm characteristics, and ISO 14001 on environmental performance. Also, this study analyzes the effect of environmental performance on the financial performance. The data analysis was performed using multiple linear regression Data collection techniques are carried out using annual reports of companies receiving PROPER Award and listed on the Indonesia Stock Exchanges in the year of 2015–2019. The results showed that Audit Committee, firm characteristics, and ISO 14001 significantly influenced environmental performance. Another result is that environmental performance has a positive effect on the financial performance. This study contributes as a reference for the government to make environmental policies so as to encourage the achievement of sustainable development goals (SDGs). This study measures environmental performance using only PROPER which cannot be generalized to all companies listed on the Indonesia Stock Exchanges and other markets. The next studies should use other proxies to measure environmental performance and use other data collection methods such as interviews.
Memory‐driven eye movements prospectively predict dementia in people at risk of Alzheimer's disease
Authors: Parra Mario A , Granada Juan , Fernández Gerardo 
Published: December 2022

AbstractIntroductionOculomotor behaviors linked to cognitive performance revealed neurocognitive features of Alzheimer's disease (AD) that can enhance the accuracy of its assessment and diagnosis.MethodsA sample of 107 participants (i.e., 65 mild cognitive impairment [MCI] and 42 controls) were recruited and followed up for 40 months. At baseline, they underwent assessment with the ViewMind digital biomarker, which draws cognitive‐related patterns of eye movement while people perform the visual short‐term memory binding task.ResultsBaseline data predicted that 36 patients with MCI would progress to the AD clinical syndrome (ADS Progressing). The remaining 29 MCI patients were predicted to remain as MCI or progress to other forms of dementia. After 40 months of follow‐up, 94% of ADS Progressing patients had received a diagnosis of dementia, whereas none of the non‐ADS Progressing had.DiscussionThe analysis of eye movement behavior combined with cognitive markers for AD can effectively predict progression to ADS among patients with MCI.
Signatures of emotional face processing measured by event‐related potentials in 7‐month‐old infants
Authors: Aran Özlü , Garcia Sarah E. , Hankin Benjamin L. , Hyde Daniel C. , Davis Elysia Poggi 
Published: December 2022

AbstractThe ability to distinguish facial emotions emerges in infancy. Although this ability has been shown to emerge between 5 and 7 months of age, the literature is less clear regarding the extent to which neural correlates of perception and attention play a role in processing of specific emotions. This study's main goal was to examine this question among infants. To this end, we presented angry, fearful, and happy faces to 7‐month‐old infants (N = 107, 51% female) while recording event‐related brain potentials. The perceptual N290 component showed a heightened response for fearful and happy relative to angry faces. Attentional processing, indexed by the P400, showed some evidence of a heightened response for fearful relative to happy and angry faces. We did not observe robust differences by emotion in the negative central (Nc) component, although trends were consistent with previous work suggesting a heightened response to negatively valenced expressions. Results suggest that perceptual (N290) and attentional (P400) processing is sensitive to emotions in faces, but these processes do not provide evidence for a fear‐specific bias across components.
Quantitative assessment of the dispersal of soil‐dwelling oribatid mites via rodents in restored heathlands
Authors: Salazar‐Fillippo Andrés A. , Teunkens Bert , Leirs Herwig , Frouz Jan , van Diggelen Rudy , Miko Ladislav 
Published: December 2022

AbstractHeathland restoration using topsoil removal requires the re‐colonization of above‐ and belowground communities. Oribatid mites play a key role in the comminution of organic matter and are frequently early colonizers during succession despite their limited mobility. Whereas the assembly of their communities may take decades, passive dispersal likely dominates colonization processes, but especially dispersal via other animals (phoresy) remains poorly studied. Compared to other potential hosts, movement habits and ecology of small rodents may provide dispersal advantages to oribatid communities. We studied dispersal of oribatid mites via small rodents in restored heathland sites of different age. We measured movement patterns of small rodents and extracted mites from their pelts and nests to estimate annual contributions of these rodents to the dispersal of oribatids. We also discussed phoretic estimates reported on other host groups as a reference. Probability estimates of oribatids in pelts and nests showed lower occurrence frequencies compared to other reported phoretic hosts. However, local rodent communities may aid the dispersal of up to 41,000 oribatid mites per year. We highlight the high diversity of oribatid species mounting rodents, unlike strong species‐specific filters reported in other passive pathways. We found that over half (58%) of the oribatid species reproduced asexually and over a third (32%) had a soil‐dwelling lifestyle. We also observed that rodents often travel short distances below 40 m, but occasionally reach distances of up to 100 m, especially in earlier successional stages.Synthesis and applications. Our results suggest that rodents may contribute to assembly processes of soil‐dwelling oribatid communities given the slow turnover rate of this group in heathlands. This is accomplished through short‐distance dispersal, and especially in sites at early stages of succession. To our knowledge, we are the first to quantitatively assess the potential dispersal of oribatid mites via rodents.
Uncertainty quantification of seismic response of nuclear reactor building using a three‐dimensional finite element model
Authors: Choi Byunghyun , Nishida Akemi , Li Yinsheng , Takada Tsuyoshi 
Published: December 2022

AbstractAfter the 2011 Fukushima accident, seismic regulations for nuclear power plants (NPPs) in Japan have been strengthened to include countermeasures beyond design‐basis events. Therefore, the importance of seismic probabilistic risk assessments is a topic that deserves attention. Generally, uncertainty quantification has been a crucial undertaking to assess the fragility of NPP buildings. This study aims to quantify realistic uncertainties using a three‐dimensional (3D) finite element (FE) model to reflect the obtained results to the conventional simple sway‐rocking (SR) model, and to develop a seismic fragility assessment method that considers 3D effects. As a first step, a 3D FE model was developed, and a seismic response analysis was performed to evaluate the seismic response of the buildings. For comparison, a seismic response analysis using the conventional SR model was performed. For input ground motions, 200 types of simulated seismic ground motions, generated using fault‐rupture models were adopted. As a second step, two types of uncertainties are evaluated for uncertainty quantification: uncertainty for input seismic ground motion and that due to different locations of equipment installed on a floor. As a third step, to reflect the 3D effect on the uncertainty of the conventional SR model, were investigated the median and logarithm standard deviation of the response ratio (3D FE/SR) of the maximum acceleration of the two models. The results of epistemic uncertainty tended to increase with the increasing elevation level and the epistemic uncertainty result in the basement floor, where important equipment was installed, was relatively small. By reflecting this epistemic uncertainty into the conventional SR model, a more realistic fragility assessment that considers the 3D effect is expected by applying this result as epistemic uncertainty of the SR model of the fragility assessment.
Total Synthesis of Aculenes B and D
Authors: Yokokawa Hinata , Ishizawa Seiya , Saito Katsuya , Meguro Yasuhiro , Kuwahara Shigefumi , Enomoto Masaru 
Published: December 2022

AbstractThe first total synthesis of aculene D, a structurally rare nordaucane‐type natural product exhibiting quorum sensing inhibitory activity, has been accomplished from a known five‐membered hydroxy carboxylic acid. Nucleophilic addition of methallylzinc bromide to a β‐keto aldehyde intermediate under Barbier conditions to install the secondary hydroxy group on the seven‐membered ring of aculene D gave the corresponding alcohol with an undesired configuration predominantly. On the other hand, the protection of its keto group as the ethylene acetal induced a reversal of diastereoselectivity, affording a desired diastereomer in a selective manner. The construction of the seven‐membered ring was realized by ring‐closing metathesis using a triethylsilyl‐protected monocyclic diene ester precursor. An additional five‐step manipulation on the cyclization product including the installation of an ethyl group on the five‐membered ring completed the synthesis of aculene D, whose esterification with an N‐protected l‐proline followed by deprotection also achieved the first total synthesis of aculene B.
Site classification using deep‐learning‐based image recognition techniques
Authors: Ji Kun , Zhu Chuanbin , Yaghmaei‐Sabegh Saman , Lu Jianqi , Ren Yefei , Wen Ruizhi 
Published: December 2022

AbstractClassification of local soil conditions is important for the interpretation of structural seismic damage, which also plays a vital role in site‐specific seismic hazard analyses. In this study, we propose to classify sites as an image recognition task using a deep convolutional neural network (DCNN)‐based technique. We design the input image as a combination of the topographic slope and the mean horizontal‐to‐vertical spectral ratio (HVSR) of earthquake recordings. A DCNN model with five convolutional layers is trained using 1649 sites in Japan. The recall rates for site classes C, D, and E using our DCNN classifier for Japanese sites are 82%, 70%, and 60%, respectively. When compared with existing site classification schemes relying on predefined standard HVSR curves, our proposed method achieves the highest total accuracy rate (between 73% and 75%). The generality and applicability of our trained classifier are further validated using sites in Europe with a total accuracy between 64% and 66%. The proposed data‐driven approach could be extended to other types of site amplification functions in the future.