bluuebunny/crossref_metadata_2025_split huggingface dataset:
The attitudes about life-sustaining treatment among cardiac surgery ICU patients and their families
Authors: Sun Si , Zhang Hao , Xiong XiaoYan 
Published: May 2023

PurposeTo investigate the attitudes among cardiac surgery ICU patients and their families regarding life-sustaining treatment.MethodsA total of 172 pairs of patients in the cardiac surgery ICU of Nanjing First Hospital and their family members were enrolled in this study that examined their attitudes toward life-sustaining treatment using a willingness to care for life-sustaining treatment questionnaire. The consistency of the attitudes of patients and family members toward life-sustaining treatment was analyzed by the chi-square test with a paired design.ResultsThe most popular life-sustaining treatment for cardiac ICU patients was noninvasive mechanical ventilation (79.1%); the most unpopular was intra-aortic balloon counterpulsation (48.3%). Most patients and their families had not considered electric defibrillation (65.7%), but most understood and were willing to permit cardiopulmonary resuscitation (76.2%). Few family members agreed that patients should receive a pacemaker (25.0%). The consistency of life support attitudes of patients and their families ranged from 12.8% to 60.5% for procedures both would agree to, 1.2% to 19.8% for procedures they were unwilling to permit, and 0.6% to 39.0% for procedures they had not considered. Kappa values ranged from 0.218 to 0.597 (P &lt; 0.05), with general consistency.ConclusionCardiac surgery ICU patients families are generally consistent in their attitudes toward life-sustaining treatment, and family members’ choices are not representative of patients’ wishes.
Livestock producers' knowledge, attitude, and behavior (KAB) regarding antimicrobial use in Ethiopia
Authors: Tufa Takele B. , Regassa Fikru , Amenu Kebede , Stegeman J. A. , Hogeveen Henk 
Published: May 2023

IntroductionInappropriate antimicrobial use (AMU) in livestock production is an important aspect of the global burden of antimicrobial resistance (AMR). In Ethiopia, a low-income country with a large and increasing livestock population, AMU in food animals is not properly regulated. Hence, farmers are fully free to use antimicrobials to their (perceived) benefit. Therefore, understanding farmers' mindsets is important to improve antimicrobial stewardship in the livestock sector.MethodsThis cross-sectional study was conducted to assess livestock disease management practices and knowledge, attitude, and behavior (KAB) among livestock producers regarding AMU, residues, and resistance, as well as factors potentially explaining differences in KAB. We determined the KAB of livestock owners of three selected districts of central and western Ethiopia (n = 457), using a pretested questionnaire administered through face-to-face interviews. Logistic regression was used to evaluate the association between potential explanatory variables and the KAB scores of the respondents.ResultsThe results showed that 44% of the farmers used antimicrobials in the past few years, where antibiotics (21%) and trypanocides (11%) were most widely used to manage livestock diseases. Furthermore, most farmers showed poor knowledge about AMU, residues, and AMR (94%) and unfavorable attitudes (&lt;50% correct answers) toward contributing factors for AMR (97%). On the contrary, 80% of the respondents had overall good behavior scores (≥50% correct answers) related to AMU. Multivariate analysis results showed that having good knowledge, keeping ≥2 animal species, and the occurrence of ≥4 livestock diseases on the farm in a year were strong predictors of bad behavior scores (p &lt; 0.05). The findings of the current investigation also revealed that the incidence of livestock diseases on the farm and a higher level of formal education significantly contributed to better knowledge and desirable attitudes but bad AMU behavior.ConclusionA low level of awareness about and undesirable attitudes toward AMU and AMR could potentially affect farmers' behavior toward judicious AMU, thus requiring awareness creation efforts on livestock disease management practices.
Effects of organic and inorganic copper on cecal microbiota and short-chain fatty acids in growing rabbits
Authors: Du Yanan , Tu Yun , Zhou Zeyang , Hong Rui , Yan Jiayou , Zhang Gong-Wei 
Published: May 2023

IntroductionCopper (Cu) is an essential trace element for the growth of rabbits. This study aimed to investigate the effects of different Cu sources on intestinal microorganisms and short-chain fatty acids (SCFAs) in growing rabbits.MethodsThe experimental animals were randomly divided into four experimental groups, each group comprised eight replicates, with six rabbits (half male and half female) per replicate. And they were fed diets was composed by mixing the basal diet with 20 mg/kg Cu from one of the two inorganic Cu (cupric sulfate and dicopper chloride trihydroxide) or two organic Cu (cupric citrate and copper glycinate). Cecal contents of four rabbits were collected from four experimental groups for 16S rDNA gene amplification sequencing and gas chromatography analysis.ResultsOur results indicate that the organic Cu groups were less variable than the inorganic Cu groups. Compared with the inorganic Cu groups, the CuCit group had a significantly higher relative abundance of Rikenella Tissierella, Lachnospiraceae_NK3A20_group, Enterococcus, and Paeniclostridium, while the relative abundance of Novosphingobium and Ruminococcus were significantly lower (p &lt; 0.05). The SCFAs level decreased in the organic Cu groups than in the inorganic Cu groups. Among the SCFAs, the butyric acid level significantly decreased in the CuCit group than in the CuSO4 and CuCl2 groups. The relative abundance of Rikenella and Turicibacter genera was significantly negatively correlated with the butyric acid level in the CuCit group compared with both inorganic Cu groups. These results revealed that the organic Cu (CuCit) group had an increased abundance of Rikenella, Enterococcus, Lachnospiraceae_NK3A20_group, and Turicibacter genera in the rabbit cecum.DiscussionIn summary, this study found that organic Cu and inorganic Cu sources had different effects on cecal microbiota composition and SCFAs in rabbits. The CuCit group had the unique higher relative abundance of genera Rikenella and Lachnospiraceae_NK3A20_group, which might be beneficial to the lower incidence of diarrhea in rabbits.
Comparative analysis of microRNA and messengerRNA expression profiles in plateau zokor testicular cells under reproductive suppression
Authors: Yao Baohui , Kang Yukun , An Kang , Tan Yuchen , Hou Qiqi , Zhang Degang , Su Junhu 
Published: May 2023

IntroductionReproductive suppression is an adaptive strategy that affects the success rate and reproductive efficiency in animals, which in turn affects population continuation and evolution. However, no studies on the miRNAs in testicular development and spermatogenesis regulatory mechanisms under reproductive suppression have been reported.MethodsIn this study, the differentially expressed (DE) miRNAs, miRNA–mRNA interaction network and function of the plateau zokor testicular cells of non-breeders and breeders during the breeding season were comprehensively analyzed by transcriptomics.ResultsIn total, 381 known and 94 novel miRNAs were determined. Compared with that in the breeders, 70 downregulated and 68 upregulated DE miRNAs were identified in the non-breeders. We predicted 1670 significant target mRNAs by analyzing the miRNA and mRNA expression profiles. According to the miRNA–mRNA interaction network, the target mRNAs of the DE miRNAs were related to testicular development and spermatogenesis. GO indicate that the target mRNAs were related to testicular development and spermatogenesis. KEGG indicate that pathways of target mRNAs enrichment related to testicular development, spermatogenesis, and energy metabolism. PROK2 was determined as the target mRNA of rno-miR-143-3p.DiscussionOur study offers a basis for the regulatory mechanisms of miRNAs in testicular development and spermatogenesis in plateau zokor under reproductive suppression and offers a reference for reproductive regulation.
A New Stochastic Model for the Aedes aegypti Life Cycle and the Dengue Virus Transmission
Authors: Cruz José-Manuel , González-Gutiérrez Jorge , Salgado-García R. , Díaz-Hernández O. 
Published: May 2023

Dengue is a viral infection transmitted mainly by the Aedes aegypti mosquito and to a lesser extent by the Aedes albopictus. This infectious disease generally causes flu-like symptoms, but it can also lead to life-threatening symptoms. Unfortunately, the number of cases increases every year and about a third part of the world’s population is at risk of contracting this disease. To generate tools capable of containing dengue transmission, we present a novel stochastic model for the Aedes aegypti life cycle and the dengue virus transmission, taking into account all the mechanisms of transmission and parameters estimated experimentally to date. This new model describes in detail all the interactions in the stages of the life cycle of the mosquito. It also considers the environmental conditions, i.e., the breeding sites and the temperature, which are very important factors for the mosquito survival. The results show that the contagion by bite only does not provoke an epidemic outbreak when five infected, pregnant, and fed females, looking for lay eggs, arrive to a susceptible human population. However, if in addition to the bite transmission, the virus is also transmitted in vertical transmission and sexual ways, then an outbreak arises. Altogether, the transmission mechanisms and the adequate environmental conditions could explain the virus persistence in the population. Under these conditions and by considering fumigation as a way to control the mosquito population, in this new model the outbreak and the virus propagation could be avoided—but only if the control is implemented within the first two weeks of the presence of the virus.
The Patient Journey of Schizophrenia in Mental Health Services: Results from a Co-Designed Survey by Clinicians, Expert Patients and Caregivers
Authors: Percudani Mauro Emilio , Iardino Rosaria , Porcellana Matteo , Lisoni Jacopo , Brogonzoli Luisa , Barlati Stefano , Vita Antonio 
Published: May 2023

Background: The Patient Journey Project aims to collect real-world experiences on schizophrenia management in clinical practice throughout all the phases of the disorder, highlighting virtuous paths, challenges and unmet needs. Methods: A 60-item survey was co-designed with all the stakeholders (clinicians, expert patients and caregivers) involved in the patient’s journey, focusing on three areas: early detection and management, acute phase management and long-term management/continuity of care. For each statement, the respondents expressed their consensus on the importance and the degree of implementation in clinical practice. The respondents included heads of the Mental Health Services (MHSs) in the Lombardy region, Italy. Results: For early diagnosis and management, a strong consensus was found; however, the implementation degree was moderate-to-good. For acute phase management, a strong consensus and a good level of implementation were found. For long-term management/continuity of care, a strong consensus was found, but the implementation level was slightly above the cut-off, with 44.4% of the statements being rated as only moderately implemented. Overall, the survey showed a strong consensus and a good level of implementation. Conclusions: The survey offered an updated evaluation of the priority intervention areas for MHSs and highlighted the current limitations. Particularly, early phases and chronicity management should be further implemented to improve the patient journey of schizophrenia patients.
Exponential Stability of Fractional Large-Scale Neutral Stochastic Delay Systems with Fractional Brownian Motion
Authors: Sathiyaraj T. , Ambika T. , Huat Ong Seng 
Published: May 2023

Mathematics plays an important role in many fields of finance. In particular, it presents theories and tools widely used in all areas of finance. Moreover, fractional Brownian motion (fBm) and related stochastic systems have been used to model stock prices and other phenomena in finance due to the long memory property of such systems. This manuscript provides the exponential stability of fractional-order Large-Scale neutral stochastic delay systems with fBm. Based on fractional calculus (FC), Rn stochastic space and Banach fixed point theory, sufficiently useful conditions are derived for the existence of solution and exponential stability results. In this study, we tackle the nonlinear terms of the considered systems by applying local assumptions. Finally, to verify the theoretical results, a numerical simulation is provided.
Modern tactics of follow-up care and treatment of patients with congenital maxillofacial defects combined with other comorbid conditions
Authors: Rogozhina Yu. S. , Blokhina S. I. , Bimbas E. S. , Galeeva K. V. 
Published: May 2023

Relevance. Questions of methodology and organization of specialized treatment of patients with congenital maxillofacial defects do not lose their relevance and retain the interest of researchers and practitioners. This article covers the accumulated experience of centralized medical examination of patients with congenital maxillofacial defects combined with other comorbid conditions in the comparative evolutionary aspect of advancing the organizational structure and follow-up care regulation.Purpose. To improve the rehabilitation process efficiency in patients with congenital maxillofacial defects complicated by other comorbid conditions by advancing the tactics of organizational and therapeutic measures.Material and methods. The study conducted an analytical and quantitative-qualitative analysis of medical documentation of the comprehensive care organizational and rehabilitation process for 2475 patients with congenital cleft face and palate for 24 years (1998-2022) in the specialized Bonum Center (Yekaterinburg). Of 2475 medical records of patients with congenital cleft face and/or palate, 823 cases (33.25%) had comorbid conditions.Results. The analysis of the results of a complex, specialized practice of multifunctional treatment of patients with congenital maxillofacial defects of complex systemic origin shows ways to improve and optimize the functionality of the rehabilitation process.Conclusions. The presented practice of improving the system for organizing follow-up care and specialized treatment of patients with maxillofacial defects complicated by other comorbid conditions allowed for the successful health restorative process completion in 55.04% of cases, including surgical assistance within the recommended rehabilitation period. The presented experience, as a concept, can serve as a guide for practitioners of specialized medicine concerning the development of a system of rehabilitation processes for patients with congenital maxillofacial defects of a complex somatic status.
La industria musical y la disrupción de la tecnología digital. El caso de la escena tropical bass en la ciudad de Lima
Authors: Bailon Jaime , Roncoroni Umberto 
Published: May 2023

Este artículo analiza los efectos disruptivos de la tecnología digital en el campo de la industria musical. Abordaremos la conformación del modelo Music 2.0, estudiado por George Yúdice, y la teoría de la larga cola de Chris Anderson. Analizaremos cómo ha sido el proceso de adaptación de los artistas a este nuevo ecosistema cultural, tomando como estudio de caso las estrategias de producción y distribución de la escena de la música electrónica tropical bass en la ciudad de Lima. Este género tiene como una de sus matrices la música chicha, que además de ser un interesante fenómeno estético, tiene a su vez una gran importancia social: designa formas de socialización de un amplio sector de la población peruana y ha sido producto de los procesos migratorios de las zonas rurales a la ciudad capital, la economía informal y la crisis política.
Patients with gastrointestinal cancer are more susceptible to unintentional weight loss after chemotherapy treatment
Authors: Segura Gabriela Gonzalez , Coletti Laura Martin , Saiane Amanda , Valentin Junior Gerson , Marins Mozart , Faccio Adilson , Fachin Ana Lúcia 
Published: May 2023

There is growing evidence showing that some chemotherapeutic agents employed for oncology treatments contribute to the induction of anorexia, leading to weight loss and the reduction of muscle mass due to the effects of treatment and the tumor, which may trigger the cachexia syndrome. Owing to the complexity of the diagnosis and body evaluation in these patients, the objective of this study was to evaluate the nutritional status of oncology patients submitted to chemotherapy treatment showing a weight loss greater than 5%. We screened 220 oncology patients and shortlisted 10 patients diagnosed with different types of tumors assisted by the Instituto Ribeirãopretano de Combate ao Câncer under chemotherapy treatment and who presented weight loss greater than 5%. Anthropometric data such as weight, height and arm circumference (AC) was used for the calculation of Body Mass Index (BMI). We also used the Arm Muscle Circumference (AMC) and Arm Muscle Area (AMB) and the application of the Oncology Patient Global Nutrition Questionnaire. The results point out that cancer patients presented different anthropometric classification pre-diagnosis and after the beginning of anticancer treatment resulting from the side effects of chemotherapeutic agents and the reduction in the volume of food ingested. Gastrointestinal tract cancer patients presented greater short-term weight loss when compared to other types of tumors. We suggest that the observed weight loss may be related to the MFLOX and FOLFOX treatment protocols, in addition to the reduction in food intake (while maintaining good nutritional quality). These factors together may lead to the reduction of life quality and life expectancy and worsened patients’ prognosis.
Pengaruh Harga, Kepercayaan Konsumen, Dan Optimasi Penggunaan Terhadap Keputusan Pembelian Konsumen Pada Masa Pandemi Covid 19 Melalui Marketplace Tokopedia Di Kota Cimahi
Authors: Hayati Nur , Mutaqin Jaenal 
Published: May 2023

<p align="justify">This study aims to analyze whether Price, Consumer Confidence and Ease of Use have a positive and significant effect partially and simultaneously on Purchase Decisions Making through the Tokopedia marketplace during the Covid 19 pandemic in South Cimahi District, Cimahi City. The research method used is a quantitative method. While the research formula used in this study is a descriptive formula. The research sample was 130 respondents using purposive sampling technique. The technique of collecting data is through the distribution of questionnaires directly and online using an ordinal scale. The results showed that there was a partial influence of consumer trust and ease of use on purchasing decisions through the Tokopedia marketplace during the Covid 19 pandemic in South Cimahi District, Cimahi City. However, there is no partial effect of price on purchasing decisions through the Tokopedia marketplace during the Covid 19 pandemic in South Cimahi District, Cimahi City. There is a significant effect of price, consumer trust, and ease of use simultaneously on purchasing decisions through the Tokopedia marketplace during the Covid 19 pandemic in South Cimahi District, Cimahi City.</p><p><strong>Keywords:</strong> Consumer Trust, Ease of Use, Pandemic Covid 19, Purchase Decision, Price.</p>
Pengaruh Locus Of Control Dan Lingkungan Kerja Terhadap Kinerja Karyawan Dengan Self Efficacy Sebagai Variabel Pemediasi
Authors: Mukti Adhitya Kuncoro , Waskito Jati 
Published: May 2023

<p align="justify">Penelitian ini bertujuan untuk menganalisis pengaruh dari <em>locus of control</em> dan lingkungan kerja terhadap kinerja karyawan dengan <em>self efficacy</em> sebagai variabel pemediasi. Dalam penelitian ini menggunkan metode penelitian kuantitatif. Populasi yang digunakan adalah karyawan pada BPJS Ketenagakerjaan di kota Surakarta dengan sampel sebanyak 55 responden. Pengambilan sampel pada penelitian ini menggunakan <em>non-probability sampling </em>dengan Teknik <em>purposive sampling</em>. Pengumpulan data dalam penelitian ini dilakukan dengan menggunakan angket kuesioner yang disebarkan kepada seluruh karyawan BPJS Ketenagakerjaan kota Surakarta. Analisis data yang digunakan adalah menggunakan<em> Smart</em> PLS. Pengujian data yang digunakan dalam penelitian ini meliputi <em>outer model </em>dan <em>inner model</em>. Hasil analisis dari penelitian ini menyimpulkan bahwa <em>Locus of control</em> berpengaruh positif dan signifikan terhadap <em>self efficacy</em>, Lingkungan kerja berpengaruh positif dan signifikan terhadap <em>self efficacy</em>, <em>Locus of control</em> berpengaruh positif dan signifikan terhadap kinerja karyawan, Lingkungan kerja berpengaruh positif dan signifikan terhadap kinerja karyawan, <em>Self efficacy</em> berpengaruh positif dan signifikan terhadap kinerja karyawan, <em>Self efficac</em>y berpengaruh positif dan signifikan dalam memediasi pada pengaruh <em>locus of control</em> terhadap kinerja karyawan, <em>Self efficac</em>y berpengaruh positif dan signifikan dalam memediasi pada pengaruh lingkungan kerja terhadap kinerja karyawan.</p><p><strong>Kata kunci</strong>: <em>Locus Of Control</em>, Lingkungan Kerja, <em>Self Efficacy</em>, Kinerja.</p>
Passionflower in the Treatment of Anxiety Disorders
Authors: Протько Н.Н. , Ситник Г.Д. , Милюк Н.С. , Теплякова К.А. 
Published: May 2023

Тревожные расстройства являются наиболее часто встречающейся группой психических расстройств. Вопросы своевременной диагностики и эффективного лечения этих заболеваний приобретают особую актуальность, прежде всего в первичном звене здравоохранения. Законом Республики Беларусь от 11.11.2019 № 255-З определены полномочия врачей общей практики в лечении психических расстройств. Среди ряда психотропных препаратов, которые применяются для лечения тревожных расстройств, отдельную группу представляют лекарственные растения с анксиолитическим эффектом. Одним из таких растений является пассифлора (Passiflora incarnata). В статье приведен анализ литературных данных по проблеме тревожных расстройств и использованию пассифлоры для их лечения. Описаны характеристика пассифлоры, ее состав, клинические эффекты и показания для применения в общей врачебной практике.
Anxiety disorders are the most common group of mental disorders. The issues of timely diagnosis and effective treatment of these diseases are of particular relevance, primarily in primary health care. The Law of the Republic of Belarus No. 255-3 of 11.11.2019 defines the powers of general practitioners in the treatment of mental disorders. Among a number of psychotropic drugs that are used to treat anxiety disorders, medicinal plants with anxiolytic effect represent a separate group. One of these plants is Passiflora (Passiflora incarnata). The article provides an analysis of the literature data on the problem of anxiety disorders and the use of passionflora for their treatment. The characteristics of passionflower, its composition, clinical effects and indications for use in general medical practice are described.