bluuebunny/crossref_metadata_2025_split huggingface dataset:
АТОПИЯЛЫҚ ДЕРМАТИТТІҢ КЛИНИКАЛЫҚ АҒЫМЫНЫҢ ЗАМАНАУИ ЕРЕКШЕЛІКТЕРІ
Authors: Сатвалдиева А.Д. 
Published: August 2023

Атопический дерматит (АД) - это один из самых частых и проблематичных дерматозов, заболеваемость которым в мире, по разным данным, может составлять до 5% населения. Начинаясь в раннем детстве, примерно в половине случаев он может протекать долгие годы, то обостряясь, то затихая с характерной сезонной зависимостью. Различные клинические проявления в разных возрастных фазах АД составляют мозаичность его клинической картины при разнообразии факторов, вызывающих обострения, и что едва ли не самое главное – приводят к формированию атопической личности с выраженным в ряде случаев психосоматическим компонентом. В данной статье изучены особенности течения АД в современных условиях. Выявлено преобладание со средне-тяжелым и тяжелым течением заболевания во всех клинических формах АД. У 50,5% больных АД протекал по непре-рывно-рецидивирующему типу с непродолжительными ремиссиями и кратковременным улучшением, преимущественно в летнее время, 17,5% пациентов с АД отмечали более тяжелое непрерывное течение заболевания в последние 2-3 года.
Atopic dermatitis (AD) is one of the most frequent and problematic dermatoses, the incidence of which in the world, according to various data, can be up to 5% of the population. Starting in early childhood, in about half of cases it can last for many years, then escalating, then subsiding with a characteristic seasonal dependence. Various clinical manifestations in different age phases of AD make up the mosaic of its clinical picture with a variety of factors causing exacerbations, and what is perhaps the most important thing – lead to the formation of an atopic personality with a pronounced psychosomatic component in some cases. This article examines the features of the course of AD in modern conditions. The prevalence of moderate and severe course of the disease in all clinical forms of AD was revealed. In 50.5% of patients, AD was of a continuously recurrent type with short-term remissions and short-term improvement, mainly in the summer, 17.5% of patients with AD noted a more severe continuous course of the disease in the last 2-3 years.
КӘМЕЛЕТКЕ ТОЛМАҒАН ЛОКАЛИЗАЦИЯЛАНҒАН СКЛЕРОДЕРМА (КЛИНИКАЛЫҚ ЖАҒДАЙ)
Authors: Сатвалдиева А.Д. 
Published: August 2023

Представлен клинический случай ювенильной локализованной склеродермии с быстро прогрессирующим, распространенным поражением кожи, вовлечением в патологический процесс подкожной клетчатки и мышц, опорно-двигательного аппарата. Поздняя диагностика заболевания в стадии атрофии привела к инвалидизации ребенка. У пациента были выявлены множественные типичные склеродермические очаги неправильной формы, с разной стадией поражения (отек, индурация и атрофия). Поражение мышц отмечалось в виде атрофии и укорочения в левой ягодичной области и бедре. Важным аспектом при ведении детей с ювенильной локализованной склеродермией является коллаборация детских ревматологов и дерматологов.
A clinical case of juvenile localized scleroderma with rapidly progressive, widespread skin lesions, involvement of subcutaneous tissue and muscles in the pathological process is presented. The late diagnosis of the disease at the stage of atrophy led to the disability of the child. The patient had multiple typical scleroderma foci of irregular shape, with different stages of lesion (edema, induration and atrophy). Muscle damage was noted in the form of atrophy and shortening in the left gluteal region and thigh. An important aspect in the management of children with juvenile localized scleroderma is the collaboration of pediatric rheumatologists and dermatologists.
ЗУД КОЖИ: СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ
Authors: Сағидолдина Л.К. , Жұмаділова Г.Ж. , Амрина Л.К. 
Published: August 2023

Мақалада эпидемиология, патогенез, жіктеу, клиникалық көрініс, дифференциалды диагностика және дәлелді медицина тұрғысынан қышу терапиясының тәсілдері туралы заманауи мәліметтер келтірілген, сонымен қатар өзіндік клиникалық бақылаулар келтірілген.
The article presents up-to-date data on approaches to itching therapy from the point of view of epidemiology, pathogenesis, classification, clinical picture, differential diagnosis and evidence-based medicine, as well as its own clinical observations.
Infusión de habilidades blandas en el currículo de la educación superior: Clave para el desarrollo de capital humano avanzado
Authors: Vera Millalén Fernando 
Published: August 2023

El campo de la educación superior está bajo presión como nunca antes, ya que necesita preparar a los estudiantes para una participación activa en el mundo del trabajo. Hoy los empleadores buscan profesionales que demuestren habilidades blandas – cualidades personales que los transforman en colaboradores más adaptables, más proactivos, más resilientes y más responsables. El objetivo del presente artículo es abrir el debate en torno a la infusión de habilidades blandas en el currículo de las Instituciones de Educación Superior (IES) y su impacto en la futura inserción laboral de los egresados. Esto dice relación con las demandas del mercado laboral y el énfasis que actualmente se está dando al desarrollo de dichas habilidades socioemocionales. La metodología utilizada consistió en el análisis documental, confrontada con los puntos de vista del autor. El aporte dice relación la necesidad de infundir las habilidades blandas en el currículo e implementar estrategias metodológicas y evaluativas que mejoren las propuestas educativas. Se concluye con una síntesis, intentando explicar las relaciones entre los conceptos clave, con sus implicancias para la educación superior.
Analisis Implementasi Open Government Melalui Aplikasi Jakarta Kini (Jaki) Pada Fitur Jak-Respon Dalam Penyebarluasan Informasi Publik
Authors: Sofiana Analia 
Published: August 2023

Tulisan ini merupakan hasil penelitian analisis penerapan open government melalui aplikasi Jakarta kini (Jaki) pada fitur jak-respons dalam penyebaran informasi publik. Pendekatan dalam penelitian ini menggunakan metode studi literatur. Teori utama yang digunakan dalam penelitian ini adalah teori open government dari Organization for Economic Co-operation and Development (OECD) dengan indikatornya. Hasil penelitian menunjukan bahwa aplikasi Jakarta kini (Jaki) Dari segi transparansi dari tindakan pemerintah, Aplikasi Jakarta Kini (Jaki) sudah terbuka secara default karena Pemerintah Provinsi DKI Jakarta secara aktif mempublikasikan data sesuai dengan informasi data yang masuk ke sistem Aplikasi Jakarta Kini (Jaki) yang dilakukan oleh perangkat daerah. Selain itu, dalam menjaga data yang bersifat rahasia pengelolaan aplikasi melakukan pengaturan dan pemilahan informasi data pada sistem. Dari segi akses terhadap layanan dan informasi dari Pemerintah, Aplikasi Jakarta Kini (Jaki) memiliki standar operasional prosedur dalam penyajian data. Selain itu, data yang dapat diakses dengan bebas biaya. Dari segi ketanggapan Pemerintah terhadap ide-ide baru, permintaan dan kebutuhan untuk peningkatan tata kelola pemerintahan dan keterlibatan warga negara, pengelolaan aplikasi JAKI organisasi perangkat daerah di lingkungan Pemerintah Provinsi DKI Jakarta dapat membuat kebijakan dengan dasar data konkret di lapangan .
Evaluasi Jakarta Kini (Jaki) Dalam Mewujudkan Jakarta Smart City (Kajian Pemanfaatan Layanan JakWifi )
Authors: Barunea Poltak Parulian , Anastasya Millenia Putri , Dalwiyanis R Nivda , Wahyuni Oktavia Sri 
Published: August 2023

Perkembangan teknologi komunikasi dan informasi saat ini sangat pesat dan mempengaruhi berbagai aspek kehidupan termasuk pada pemerintahan yang mulai menggunakan budaya kerja digitalasai. Saat ini Pemerintah Provinsi DKI Jakarta membangun aplikasi JAKI (Jakarta Kini) sebagai salah satu sarana dalam meningkatkan layanan public bagi seluruh masyarakat Jakarta. JAKI merupakan aplikasi digital yang dibuat dengan berbagai fitur yang pemanfaatannya sesuai dengan kegunaannya masing-masing. Pembangunan Aplikasi JAKI oleh Pemerintah Provinsi DKI Jakarta yang dimanfaatkan untuk mengakses berbagai informasi yang diperlukan oleh warga Jakarta tersebut, kini dapat lebih optimal penggunaannya dengan menyediakan juga fitur JakWifi yang memberikan layanan akses internet dengan teknologi wireless fidelity (Wi-Fi) secara gratis di berbagai ruang publik. Dukungan akses internet gratis ini merupakan langkah yang dipersiapkan dalam menuju Jakarta sebagai suatu Smart City yaitu suatu konsep pengembangan kota yang menekankan pada pembentukan kemandirian kota melalui penerapan digitalisasi mengintegrasikan kemajuan teknologi informasi dan komunikasi (TIK) terkini dalam tata kelola pemerintahan nya yang dikenal sebagai konsep Digital Governance. Metode yang digunakan pada penelitian ini menggunakan metode deskriptif kualitatif dengan menggunakan berbagai sumber data baik primer berupa observasi lapangan melalui penggunaan JakWifi dan wawancara kepada para mahasiswa Universitas 17 Agustus 1945. Hasil penelitian menunjukkan bahwa penyediaan sarana internet gratis pada ruang publik Berbasis TIK di DKI Jakarta masih terkendala oleh berbagai limitasi baik konektivitas dan kemudahan penggunaan aplikasi dan lokasi yang terbatas serta aspek keamanan data pribadi sehingga agar dapat mendukung program Jakarta Smart City masih memerlukan pengembangaan JakWifi serta penyediaan kebutuhan sarana TIK lainnya.
EDIL3 is a potential prognostic biomarker that correlates with immune infiltrates in gastric cancer
Authors: Ke Bin , Liang Zheng-Kai , Li Bin , Wang Xue-Jun , Liu Ning , Liang Han , Zhang Ru-Peng 
Published: August 2023

Background
EDIL3, which contains epidermal growth factor-like repeats and discoidin I-like domains, is a secretory protein that plays an important role in embryonic development and various illnesses. However, the biological function of EDIL3 in gastric cancer (GC) is still unclear. The objective of this research was to explore the role and potential mechanism of EDIL3 in GC.

Methods
In this study, we used the GEPIA, HPA, MethSurv, SMART, STRING, GeneMANIA, LinkedOmics TIMER, TIMER2.0, TISIDB, and RNAactDrug databases to comprehensively analyze the roles of EDIL3 in GC. To validate the in silico findings, EDIL3 expression was measured in our collected GC tissues. Meanwhile, several in vitro experiments were performed to test the function of EDIL3 in GC.

Results
We found that EDIL3 was highly expressed in GC and associated with adverse clinical features. In vitro assays revealed that EDIL3 promoted the proliferation, migration, and invasion of GC cells. The functions of EDIL3 and co-expression genes were significantly associated with extracellular structure organization and matrix receptor interaction. EDIL3 expression was positively associated with numerous tumor-infiltrating immune cells and their biomarkers.

Conclusion
This study determined that EDIL3 may function as an oncogene and is associated with immune infiltration in GC. EDIL3 could be used as a potential therapeutic target for GC.
In-vitro Assessment of Native Plant Growth Promoting Rhizobacterial Isolates Against Diverse Fungal Phytopathogens
Authors: Pradhan S. , Jena M. K. 
Published: August 2023

Although many Plant growth promoting rhizobacteria (PGPR) are used commercially, there is a need to explore more biocontrol agents to combat various pathogens and sustain the productivity of crops. PGPRs inhabit the rhizosphere region of plant and are effective in managing various pathogens. In this study, twenty-six PGPR isolates were screened in-vitro against various fungal phytopathogens in the Plant Bacteriological Laboratory, Department of Plant Pathology, Bidhan Chandra Krishi Vishwavidyalaya, Mohanpur, Nadia, West Bengal during 2021-22. All the thirteen native Bacillus isolates, showed antagonistic activity against Alternaria alternata, Colletotrichum gloeosporioides, Pestalotiopsis sp., Rhizoctonia solani and Sclerotium rolfsii. Among the thirteen fluorescent pseudomonads, all showed antagonistic activity against A. alternata, C. gloeosporioides and Pestalotiopsis sp., eight, CK2LPP, CK2LP8, CK2LP12, GP2, GP8, G11SP37, K11SP4 and S21SP14, against R. solani, two, GP2 and GP8, against S. rolfsii. BRB 42, BRB 56, PR 18, GP2 and GP8 had the highest antagonistic activity against the fungal pathogens under in-vitro condition based on average mycelium inhibition per cent. BRB 56, SM 9 and GP8, showed the maximum inhibition zone against all the phytopathogens.
Antimicrobial Effects of Aqueous Extract of Garcinia Kola Nuts on Salmonella Isolates from Chicken Dropping in Southern Taraba, North East, Nigeria
Authors: Abhadionmhen Abel Onolunosen , Anyiam Vivian Ifeoma , Imarenezor Edobor Peter Kenneth , Amiegbebhor Pius 
Published: August 2023

Aim: The onerous threat of antimicrobial resistance to public health highlights the need for continuous research that will discover more potential medicinal plants that possess inhibitory potentials on bacteria especially those with multidrug-resistant qualities. Hence, this study investigated the antibacterial effect of hot and cold aqueous extracts of Garcinia Kola on Salmonella isolates.
Study Design: This is experimental research involving fecal sample of chicken.
Place and Duration of Study: This research was carried out in Wukari metropolis.
Study Design: Sterile universal containers were used to collect one gram each of chicken fecal samples from domestic chicken coops and dissolved in Buffered Peptone Water to recover injured cell. A loop-full of the sample was streaked on prepared Salmonella-Shigella Agar plates. Suspected isolates were confirmed molecularly using PCR to identify the invA virulent gene from the isolate. Hot and cold water served as a menstruum for extracting bioactive contents from Garcinia Kola. Following evaporation of the crude hot and cold-water extracts, 0.25 mg, 0.5 mg, 1.0 mg, and 2.0 mg of the extract were respectively dissolved into 10 ml of distilled water. The Agar-well diffusion method was used in conducting the antimicrobial susceptibility tests.
Results: Significant zone of inhibition (ZIB) of 9 mm, 12 mm and 17 mm was observed for isolates subjected to 0.50 mg-10 ml, 1.00mg-10 ml, and 2.00 mg-10 ml concentrations of cold-water extracts respectively while No zone of Inhibition (NZI) was observed at 0.25 g-10 ml concentrations. For hot water extracts, growth inhibition ranging from 9 mm, 11 mm, 15 mm, and 23 mm was respectively noticed for concentrates of 0.25 mg-10 ml, 0.50 mg-10, 1.00 mg-10 ml, and 2.00 mg-10 ml. Heavy growth persisted for the negative control plate which contained distilled water without extracts. Augmentin 30 µg was used as a positive control (≥31 mm).
Conclusion: This research simply has amplified the medicinal importance of the consumption of Garcinia Kola particularly as it relates to the management of gastroenteritis caused by Zoonotic Non-enteric Salmonella. However, the clinical toxicity and safety of the plant need more understanding.
Maternal Risk of Cardiovascular Disease After Use of Assisted Reproductive Technologies
Authors: Magnus Maria C. , Fraser Abigail , Håberg Siri E. , Rönö Kristiina , Romundstad Liv Bente , Bergh Christina , Spangmose Anne Lærke , Pinborg Anja , Gissler Mika , Wennerholm Ulla-Britt , Åsvold Bjørn Olav , Lawlor Deborah A. , Opdahl Signe 
Published: August 2023

ImportanceThe use of assisted reproductive technologies (ARTs) is steadily increasing worldwide. The outcomes associated with treatment for an individual’s long-term health, including risk of cardiovascular disease (CVD), remain largely unknown, due to the small number of studies and their limited follow-up time.ObjectiveTo study whether the risk of CVD is increased among individuals who have given birth after ART compared with those who have given birth without ART.Design, Setting, and ParticipantsA registry-based cohort study was conducted using nationwide data from Denmark (1994-2014), Finland (1990-2014), Norway (1984-2015), and Sweden (1985-2015). Data analysis was conducted from January to August 2022. A total of 2 496 441 individuals with a registered delivery in the national birth registries during the study period were included, and 97 474 (4%) of these gave birth after ART.ExposuresData on ART conception were available from ART quality registries and/or medical birth registries.Main Outcomes and MeasuresInformation on CVD was available from patient and cause of death registries. The risk of CVD was estimated with Cox proportional hazards regression, adjusting for age, calendar year of start of follow-up, parity, diagnosis of polycystic ovary syndrome, diabetes, chronic hypertension, and country.ResultsMedian follow-up was 11 (IQR, 5-18) years. The mean (SD) age of women with no use of ART was 29.1 (4.9) years, and the age of those who used ART was 33.8 (4.7) years. The rate of any CVD was 153 per 100 000 person-years. Individuals who gave birth after using ART had no increased risk of CVD (adjusted hazard ratio [AHR], 0.97; 95% CI, 0.91-1.02), with evidence of heterogeneity between the countries (I2 = 76%; P = .01 for heterogeneity). No significant differences in the risk of ischemic heart disease, cerebrovascular disease, stroke, cardiomyopathy, heart failure, pulmonary embolism, or deep vein thrombosis were noted with use of ART. However, there was a tendency for a modest reduction in the risk of myocardial infarction (AHR, 0.80; 95% CI, 0.65-0.99), with no notable heterogeneity between countries.Conclusions and RelevanceThe findings of this study suggest that women who gave birth after ART were not at increased risk of CVD over a median follow-up of 11 years compared with those who conceived without ART. Longer-term studies are needed to further examine whether ART is associated with higher risk of CVD.
Association of the 2021 Child Tax Credit Advance Payments With Low Birth Weight in the US
Authors: Margerison Claire E. , Zamani-Hank Yasamean , Catalano Ralph , Hettinger Katlyn , Michling Timothy R. , Bruckner Tim A. 
Published: August 2023

ImportanceInfants and pregnant people in the US fare worse on almost all health measures compared with those in peer nations. Families in the US are more likely to live in poverty and have a less generous social safety net, which has generated debate over the contribution of economic conditions to this disparity.ObjectiveTo assess the association between temporary increases in income during pregnancy through the 2021 expanded Child Tax Credit (CTC) and birth outcomes.Design, Setting, and ParticipantsThis cross-sectional study applied a comparison-population, interrupted time series design to data from US birth certificates (January 1, 2014, through December 31, 2021) to test whether the log odds of low birth weight (LBW) among monthly cohorts of births exposed to the CTC would coincide with a decreased incidence of LBW. All singleton live births to US residents aged 15 to 49 years with available data were included.ExposureMonthly birth cohorts exposed to the CTC were defined as those born to parous people during the CTC advance payment period from July through December 2021.Main Outcomes and MeasuresThe main outcome was the natural logarithm of the odds of LBW (&amp;lt;2500 g) among monthly birth cohorts.ResultsAmong included births (n = 28 866 466), 61.2% were to parous people, the majority were to people aged 20 to 39 years (91.7%), and 6.5% were born LBW. The odds of LBW increased above expected values in 5 of the 6 months of the CTC payments (range of increases, 3.3%-5.4% across the 5 months). The outlier-adjusted odds of LBW increased, on average, by 4.2% (95% CI, 2.7%-5.7%) among the monthly birth cohorts exposed to the CTC.Conclusions and RelevanceThis study found that the odds of LBW among birth cohorts exposed to the CTC increased above expected values in 5 of the 6 months of the CTC advance payments. Additional research is needed to evaluate rival explanations for this increase in LBW among births exposed to the CTC payments.
Different Gabapentin and Pregabalin Dosages for Perioperative Pain Control in Patients Undergoing Spine Surgery
Authors: Tsai Sung Huang Laurent , Hu Ching-Wei , El Sammak Sally , Durrani Sulaman , Ghaith Abdul Karim , Lin Che Chung Justin , Krzyż Ewa Zuzanna , Bydon Mohamad , Fu Tsai Sheng , Lin Tung Yi 
Published: August 2023

IMPORTANCEPatients undergoing spine surgery often experience severe pain. The optimal dosage of pregabalin and gabapentin for pain control and safety in these patients has not been well established.OBJECTIVETo evaluate the associations of pain, opioid consumption, and adverse events with different dosages of pregabalin and gabapentin in patients undergoing spine surgery.DATA SOURCESPubMed/MEDLINE, Embase, Web of Science, Cochrane library, and Scopus databases were searched for articles until August 7, 2021.STUDY SELECTIONRandomized clinical trials conducted among patients who received pregabalin or gabapentin while undergoing spine surgery were included.DATA EXTRACTION AND SYNTHESISTwo investigators independently performed data extraction following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) reporting guideline. The network meta-analysis was conducted from August 2022 to February 2023 using a random-effects model.MAIN OUTCOMES AND MEASURESThe primary outcome was pain intensity measured using the Visual Analog Scale (VAS), and secondary outcomes included opioid consumption and adverse events.RESULTSTwenty-seven randomized clinical trials with 1861 patients (median age, 45.99 years [range, 20.00-70.00 years]; 759 women [40.8%]) were included in the systematic review and network meta-analysis. Compared with placebo, the VAS pain score was lowest with gabapentin 900 mg per day, followed by gabapentin 1200 mg per day, gabapentin 600 mg per day, gabapentin 300 mg per day, pregabalin 300 mg per day, pregabalin 150 mg per day, and pregabalin 75 mg per day. Additionally, gabapentin 900 mg per day was found to be associated with the lowest opioid consumption among all dosages of gabapentin and pregabalin, with a mean difference of −22.07% (95% CI, −33.22% to −10.92%) for the surface under the cumulative ranking curve compared with placebo. There was no statistically significant difference in adverse events (nausea, vomiting, and dizziness) among all treatments. No substantial inconsistency between direct and indirect evidence was detected for all outcomes.CONCLUSIONS AND RELEVANCEThese findings suggest that gabapentin 900 mg per day before spine surgery is associated with the lowest VAS pain score among all dosages. In addition, no differences in adverse events were noted among all treatments.