bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of e‐government services on customer satisfaction in the private sector: A case study of the Kingdom of Bahrain (SIJILAT), an online commercial registration
Authors: AL‐Kaabi Reem 
Published: May 2023

AbstractCountless e‐government program initiatives have been introduced to profit each section of society in the Kingdom of Bahrain: citizens, residents, government entities, and workers' business ventures. It is getting more important to have e‐Government systems to supply services to businesses that use them (e‐G2B). To improve the Kingdom's national economy, the Information and Government Authority (IGA) has launched a virtual one‐stop solution available through multiple channels offering a unified service where citizens and Commercial Registration holders can use a single streamlined form to apply, renew or terminate multiple licenses concurrently; this is the Business License Information System (SIJILAT). This study aims to assess Bahraini customers' satisfaction with the SIJILAT service. A quantitative method is followed with a questionnaire to gather data; six factors: accessibility, information, security, reliability, trust, and perceived ease of use found to effectively affect service quality, and, in which it affects positively and enhances customer satisfaction. The theoretical contribution of this research will enhance the theoretical literature and knowledge related to its topic. The current research will contribute to the few studies conducted in Bahrain and the Middle East on e‐government and customer satisfaction with these services. A key outcome of the research will be the ability of e‐government officials who make decisions to determine the significant factors that play a role in G2B success, particularly ones to which they should pay attention to obtain the maximum return on their technology investment.
Disruptive technologies for smart farming in developing countries: Tomato leaf disease recognition systems based on machine learning
Authors: Kovvuri Ravichandra Reddy , Kaushik Abhishek , Yadav Sargam 
Published: May 2023

AbstractFood security is a major concern in every developing country. Farmers face many problems while cultivating plants and they must take precautions at every stage of cultivation. Plants get diseases for various reasons like bacteria, insects, and fungus. Some diseases can be detected by examining the symptoms on the leaves. Early detection of diseases is a major concern and may require a thorough examination of the plants by an agricultural professional. This process is expensive and time taking. Machine learning (ML) algorithms help in image recognition and can be used to detect diseases on time without the need of an agricultural professional. In this project, the diseases in tomato leaves will be detected using image processing. The data from the images are extracted using different vectorization methods and classification algorithms like logistic regression (LR), support vector machine (SVM), and k‐nearest neighbors (KNN). Vectors of size 32 × 32 and 64 × 64 are used for training with normalizer scaling and no scaling. Out of the different approaches that were explored, SVM with the radial basis function (RBF) kernel gives the highest accuracy of 85% with no scaling and 64 × 64 image dimension.
Characteristics of transcription profile, adhesion and migration of SETD2‐loss Met‐5A mesothelial cells exposed with crocidolite
Authors: Yang Dan , Chen Chiyun , Xia Hailing , Chen Junqiang , Yu Min 
Published: May 2023

AbstractAsbestos is a fibrous silicate mineral exhibiting biopersistence and carcinogenic properties and contributes to mesothelioma. Despite the concept of gene‐environmental interaction in pathogenesis of mesothelioma, the possible pathophysiological changes of mesothelial cells simultaneously with SET domain containing 2 (SETD2) loss and asbestos exposure remains obscure. Herein, CRISPR/Cas9‐mediated SETD2 knockout Met‐5A mesothelial cells (Met‐5ASETD2‐KO) were established and exposed with crocidolite, an amphibole asbestos. Cell viability of Met‐5ASETD2‐KO appeared to dramatically decrease with ≥2.5 μg/cm2 crocidolite exposure as compared with Met‐5A, although no cytotoxicity and apoptosis changes of Met‐5ASETD2‐KO and Met‐5A was evident with 1.25 μg/cm2 crocidolite exposure for 48 h. RNA sequencing uncovered top 50 differentially expressed genes (DEGs) between 1.25 μg/cm2 crocidolite exposed Met‐5ASETD2‐KO (Cro‐Met‐5ASETD2‐KO) and 1.25 μg/cm2 crocidolite exposed Met‐5A (Cro‐Met‐5A), and ITGA4, THBS2, MYL7, RAC2, CADM1, and CLDN11 appeared to be the primary DEGs involved with adhesion in gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Cro‐Met‐5ASETD2‐KO had strong migration but mild adhesion behavior as compared with Cro‐Met‐5A. Additionally, crocidolite tended to increase migration of Met‐5ASETD2‐KO but inhibited migration of Met‐5A when compared with their corresponding cells without crocidolite exposure, although no further adhesion property changes was evident for both cells in response to crocidolite. Therefore, crocidolite may affect adhesion‐related gene expression and modify adhesion and migration behavior for SETD2‐depleted Met‐5A, which could provide preliminary insight regarding the potential role of SETD2 in the cell behavior of asbestos‐related malignant mesothelial cell.
Being a mentor in the digital era: An exploratory study of the benefits undergraduate student mentors derived from providing virtual mentoring to youth
Authors: Andersen Tia S. , Wellen Hadley 
Published: May 2023

AbstractThe purpose of the study was to understand mentors' perceptions of the benefits they derived from providing virtual mentoring to youth at risk of school failure and justice system involvement in an alternative school‐based mentoring program. Using data collected from 38 university student mentors, we used a qualitative case study design focused on generating highly credible descriptions of mentors' perceptions of how they were affected by their experiences providing virtual mentoring. The three conceptual themes that emerged in our analysis were that virtual mentors described experiencing the following outcomes: (1) the reduction of biases and development of cultural humility, (2) the development of communication and leadership skills, and (3) a cultivation of civic responsibility and a sense of empowerment to make a difference. These findings suggest that providing virtual mentoring to youth may be one important tool for building competencies for undergraduate students.
Preparation of hydrochar by one‐step hydrothermal carbonization with potassium ferrate‐assisted activation for the removal of tetracycline in water
Authors: He Tong , Zhou Xuesong , Bao Zhichao , Fu Shiyu , Lin Xiuyi 
Published: May 2023

AbstractBACKGROUNDWoody biomass has a low hydrothermal‐carbonization (HTC) degree and the hydrolysis process of some of its components is similar to that of saccharides. To improve the adsorption performance of wood‐chips hydrothermal char (hydrochar) for tetracycline in water, molasses and potassium ferrate (K2FeO4) were added to its HTC process; K2FeO4 catalyzed the carbonization of raw materials and the surface of wood chips and saccharides in molasses, along with the iron ions mutually polymerized, added more reactive‐oxygen functional groups to the hydrochar surface. The effects of K2FeO4 and molasses on the morphology, pore structure, surface oxygen‐containing functional groups, and tetracycline‐adsorption properties of hydrothermal carbon were investigated.RESULTSThe strong oxidizing properties of K2FeO4 promoted the hydrolysis of raw material. The modified hydrochar formed more oxygen‐containing functional groups and produced FeO bonds with an increased specific surface area. For the adsorption of tetracycline in water, the pseudo‐second‐order kinetic model and Freundlich isotherm were more consistent with the hydrochar‐adsorption process. The adsorption mechanism favored a combination of physical and chemical adsorption, with chemisorption being predominant. The maximum tetracycline‐adsorption capacity of HTC–0.15Fe was 119.7 mg g−1, which is significantly higher than that of unmodified hydrochar HTC‐C (56.4 mg g−1). Furthermore, molasses addition effectively improved the hydrochar structure, forming carbon‐coated iron‐core particles on its surface, which increased adsorption performance.CONCLUSIONK2FeO4‐catalyzed hydrochar produced from wood chips and sugarcane molasses is an effective adsorbent for tetracycline removal from water. This work provides innovative insights into the recycling and effective use of wood chips and molasses for environmental remediation and waste treatment. © 2023 Society of Chemical Industry (SCI).
Sub‐types of insomnia in adolescents: Insights from a quantitative/molecular twin study
Authors: Madrid‐Valero Juan J. , Rijsdijk Frühling , Selzam Saskia , Zavos Helena M. S. , Schneider Melanie , Ronald Angelica , Gregory Alice M. 
Published: May 2023

AbstractBackgroundInsomnia with short sleep duration has been postulated as more severe than that accompanied by normal/long sleep length. While the short duration subtype is considered to have greater genetic influence than the other subtype, no studies have addressed this question. This study aimed to compare these subtypes in terms of: (1) the heritability of insomnia symptoms; (2) polygenic scores (PGS) for insomnia symptoms and sleep duration; (3) the associations between insomnia symptoms and a wide variety of traits/disorders.MethodsThe sample comprised 4000 pairs of twins aged 16 from the Twins Early Development Study. Twin models were fitted to estimate the heritability of insomnia in both groups. PGS were calculated for self‐reported insomnia and sleep duration and compared among participants with short and normal/long sleep duration.ResultsHeritability was not significantly different in the short sleep duration group (A = 0.13 [95%CI = 0.01, 0.32]) and the normal/long sleep duration group (A = 0.35 [95%CI = 0.29, 0.40]). Shared environmental factors accounted for a substantial proportion of the variance in the short sleep duration group (C = 0.19 [95%CI = 0.05, 0.32]) but not in the normal/long sleep duration group (C = 0.00 [95%CI = 0.00, 0.04]). PGS did not differ significantly between groups although results were in the direction expected by the theory. Our results also showed that insomnia with short (as compared to normal/long) sleep duration had a stronger association with anxiety and depression (p < .05)—although not once adjusting for multiple testing.ConclusionsWe found mixed results in relation to the expected differences between the insomnia subtypes in adolescents. Future research needs to further establish cut‐offs for ‘short’ sleep at different developmental stages and employ objective measures of sleep.
M2 macrophage marker CHI3L2 could serve as a potential prognostic and immunological biomarker in glioma by integrated single‐cell and bulk RNA‐Seq analysis
Authors: Qian Wenbo , Wang Qi , Zhang Chi , Zhu Junle , Zhang Qing , Luo Chun 
Published: May 2023

AbstractBackgroundCHI3L2 plays a crucial role in multiple cancers, but its importance in glioma remains unclear. Hence, we comprehensively integrated bulk RNA‐sequencing (RNA‐seq), proteomics and single‐cell RNA‐seq (scRNA‐seq) to determine the roles of CHI3L2 in gliomas.MethodsBulk RNA‐seq, proteomics and scRNA‐seq data of CHI3L2 in glioma were obtained from online databases. The quantitative real‐time polymerase chain reaction (qRT‐PCR) and immunohistochemistry (IHC) were conducted to verify the CHI3L2 expression. Then, univariate and multivariate Cox regression analyses, Norman charts and gene set enrichment analysis (GSEA) were performed. Finally, the associations between CHI3L2 and tumor immunity were explored.ResultsThe expression of CHI3L2 was markedly higher in glioma cancers compared with normal tissues from analysis of the data of the Cancer Genome Atlas and Chinese Glioma Genome Atlas datasets and as verified by GSE4290, GSE50161, qRT‐PCR and IHC results (p < 0.05). High expression of CHI3L2 suggested poor overall survival (OS) prognosis in gliomas (p < 0.05). CHI3L2 might also serve as an independent predictor of OS for gliomas (p < 0.05) and we also constructed a Norman chart to predict these patients’ survival prognosis with good performance. GSEA analysis showed that CHI3L2 might be involved with eight pathways in gliomas. Regarding tumor immunity, CHI3L2 was found to be significantly involved with immune cell infiltration levels of low‐grade glioma, the tumor immune microenvironment, immune checkpoints and immune cells in both low‐grade glioma and glioblastoma (p < 0.05). Additionally, scRNA‐seq data for CHI3L2 in glioma from the TISCH2 website showed that CHI3L2 is mainly expressed in astrocytes, endothelial cells, CD8+ T cells, mono/macrophage cells, etc.ConclusionsCHI3L2 presents prognostic and immunological values in glioma, providing novel therapeutic targets for glioma patients.
Making Learning Visible: Observable Correlates of the Aha! Moment when Moving from Surface to Deep Thinking
Authors: Berckley Jay , Hattie John 
Published: May 2023

ABSTRACTThe purpose of this study is to provide reliable evidence of the observable correlates of the Aha! moment and what this means for moving from surface to deep thinking. The study analyses facial expressions and body language from video recordings of students solving problems, followed by interviews, focus groups, and surveys. The problem‐solving involved asking students to solve word problems to generate an Aha! moment and seeing how their expressions changed (or not) when they ascertained the correct answer. Findings showed clear facial, emotional, and body language changes when the problems were solved. Implications for teaching are discussed.
Grüneisen parameters, bulk modulus, and thermal expansion coefficient of Na3MCO3PO4 (M = Mn, Fe, Co, and Ni) carbonophosphates
Authors: Amaral Ian R. , Vasconcelos Daniel M. , Souza Filho Antonio G. , Oliveira Victor V. , Alencar Rafael S. , de Menezes Alan S. , Lobato Raphael L. M. , Montoro Luciano A. 
Published: May 2023

AbstractTechnological advances in recent decades have made the growing demand for energy one of the main bottlenecks for the development of more complex equipment and processes, requiring a constant search to more efficient materials and techniques that increase the efficiency of energy storage devices. Making use of Raman, X‐ray diffraction (XRD), and first‐principles calculation techniques, applied in Na3MCO3PO4 (M = Mn, Fe, Co, Ni) carbonophosphates in a wide range of pressure and temperature, several thermoelastic and structural parameters were determined. Grüneisen parameters, bulk modulus, and thermal expansion coefficient, as well as the anisotropy under pressure and temperature change, were satisfactorily quantified, characterizing the distinct molecular ambient from the carbonate and phosphate groups of these materials. The results indicate an increasing stiffness and a greater anharmonic contribution as we move towards a more compact structure, indicating an increase in its phonon–phonon interaction.
Development and application of fruit and vegetable based green films with natural bio‐actives in meat and dairy products: a review
Authors: Thakur Neha , Raposo António 
Published: May 2023

AbstractIn recent years, foodborne outbreaks and food plastic waste accumulation in the environment have impelled a hunt for new, sustainable, novel and innovatory food packaging interventions to face microbial contamination, food quality and safety. Pollution caused from wastes generated by agricultural activities is one of chief rising concerns of the environmentalists across the globe. A solution to this problem is effective and economic valorization of residues from agriculture sector. It would ensure that the by‐products/residues from one activity act as ingredients/raw materials for another industry. An example is fruit and vegetable waste based green films for food packaging. Edible packaging is a well‐researched area of science where numerous biomaterials have been already explored. Along with dynamic barrier properties, these biofilms often exhibit antioxidant and antimicrobial properties as function of the bioactive additives (e.g. essential oils) often incorporated in them. Additionally, these films are made competent by use of recent technologies (e.g. encapsulation, nano‐emulsions, radio‐sensors) to ensure high end performance and meet the principles of sustainability. Livestock products such as meat, poultry and dairy products are highly perishable and depend largely upon the mercy of packaging materials to enhance their shelf life. In this review, all the above‐mentioned aspects are thoroughly covered with a view to project fruit and vegetable based green films (FVBGFs) as a potential and viable packaging material for livestock products, along with a discussion on role of bio‐additives, technological interventions, properties and potential applications of FVBGFs in livestock products. © 2023 Society of Chemical Industry.
Atomic decomposition for preduals of Sobolev multiplier spaces
Authors: Ooi Keng Hao 
Published: May 2023

AbstractWe characterize the preduals of Sobolev multiplier spaces by means of atomic decomposition. It will be shown that the vanishing integral condition plays a main role in the atomic decomposition. Certain subspaces of the preduals which consist of functions with vanishing integrals are also studied.
Levodopa Dose Equivalency in Parkinson's Disease: Updated Systematic Review and Proposals
Authors: Jost Stefanie T. , Kaldenbach Marie‐Ann , Antonini Angelo , Martinez‐Martin Pablo , Timmermann Lars , Odin Per , Katzenschlager Regina , Borgohain Rupam , Fasano Alfonso , Stocchi Fabrizio , Hattori Nobutaka , Kukkle Prashanth Lingappa , Rodríguez‐Violante Mayela , Falup‐Pecurariu Cristian , Schade Sebastian , Petry‐Schmelzer Jan Niklas , Metta Vinod , Weintraub Daniel , Deuschl Guenther , Espay Alberto J. , Tan Eng‐King , Bhidayasiri Roongroj , Fung Victor S.C. , Cardoso Francisco , Trenkwalder Claudia , Jenner Peter , Ray Chaudhuri K. , Dafsari Haidar S. ,   the International Parkinson and Movement Disorders Society Non‐Motor Parkinson Disease Study Group
Published: May 2023

AbstractBackgroundTo compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark drug in PD pharmacotherapy as ‘levodopa equivalent dose’ (LED). Currently, the LED conversion formulae proposed in 2010 by Tomlinson et al. based on a systematic review are predominantly used. However, new drugs with established and novel mechanisms of action and novel formulations of longstanding drugs have been developed since 2010. Therefore, consensus proposals for updated LED conversion formulae are needed.ObjectivesTo update LED conversion formulae based on a systematic review.MethodsThe MEDLINE, CENTRAL, and Embase databases were searched from January 2010 to July 2021. Additionally, in a standardized process according to the GRADE grid method, consensus proposals were issued for drugs with scarce data on levodopa dose equivalency.ResultsThe systematic database search yielded 3076 articles of which 682 were eligible for inclusion in the systematic review. Based on these data and the standardized consensus process, we present proposals for LED conversion formulae for a wide range of drugs that are currently available for the pharmacotherapy of PD or are expected to be introduced soon.ConclusionsThe LED conversion formulae issued in this Position Paper will serve as a research tool to compare the equivalence of antiparkinsonian medication across PD study cohorts and facilitate research on the clinical efficacy of pharmacological and surgical treatments as well as other non‐pharmacological interventions in PD. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Adaptive Deep Brain Stimulation: From Experimental Evidence Toward Practical Implementation
Authors: Neumann Wolf‐Julian , Gilron Roee , Little Simon , Tinkhauser Gerd 
Published: May 2023

AbstractClosed‐loop adaptive deep brain stimulation (aDBS) can deliver individualized therapy at an unprecedented temporal precision for neurological disorders. This has the potential to lead to a breakthrough in neurotechnology, but the translation to clinical practice remains a significant challenge. Via bidirectional implantable brain‐computer‐interfaces that have become commercially available, aDBS can now sense and selectively modulate pathophysiological brain circuit activity. Pilot studies investigating different aDBS control strategies showed promising results, but the short experimental study designs have not yet supported individualized analyses of patient‐specific factors in biomarker and therapeutic response dynamics. Notwithstanding the clear theoretical advantages of a patient‐tailored approach, these new stimulation possibilities open a vast and mostly unexplored parameter space, leading to practical hurdles in the implementation and development of clinical trials. Therefore, a thorough understanding of the neurophysiological and neurotechnological aspects related to aDBS is crucial to develop evidence‐based treatment regimens for clinical practice. Therapeutic success of aDBS will depend on the integrated development of strategies for feedback signal identification, artifact mitigation, signal processing, and control policy adjustment, for precise stimulation delivery tailored to individual patients. The present review introduces the reader to the neurophysiological foundation of aDBS for Parkinson's disease (PD) and other network disorders, explains currently available aDBS control policies, and highlights practical pitfalls and difficulties to be addressed in the upcoming years. Finally, it highlights the importance of interdisciplinary clinical neurotechnological research within and across DBS centers, toward an individualized patient‐centered approach to invasive brain stimulation. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.