bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chiral Ruthenium Halide Semiconductor with Strong Antiferromagnetic Coupling
Authors: Lu Haolin , He Tengfei , Wu Haolin , Qi Fenglian , Wang Hebin , Sun Bing , Shao Tianyin , Qiao Tianjiao , Zhang Hao‐Li , Sun Dali , Chen Yongsheng , Tang Zhiyong , Long Guankui 
Published: September 2023

AbstractChiral hybrid organic–inorganic metal halides have attracted wide attention owing to their superior chiroptoelectronic and chirospintronic properties. Here, a new class of chiral lead‐free metal halides, (R/S‐MBA)3Ru2Br9 (MBA = methylbenzylammonium), with unique magnetic properties is reported. (R/S‐MBA)3Ru2Br9 is composed of a surface‐shared octahedron dimer separated by chiral cations and crystallizes into the Sohncke space group of P212121. The crystal structures, chiroptical, magnetic properties, and magnetic circular dichroism of (R/S‐MBA)3Ru2Br9 are systematically investigated. Owing to the strong antiferromagnetic coupling between the Ru atom through bromine bridge in the [Ru2Br9]3− dimer and the weak ferromagnetic coupling between the neighboring [Ru2Br9]3− dimer, (R/S‐MBA)3Ru2Br9 exhibits antiferromagnetic property with Néel temperature at 7 K. Considering the unique magnetic property of ruthenium, together with the rapid progress of antiferromagnetic spintronics and optospintronics recently, this work provides a novel multifunctional lead‐free chiral magnetic candidate toward chiral optoelectronics and antiferromagnetic spintronics.
Defective Engineering Tuning the Analog Switching Linearity and Symmetry of Two‐Terminal Artificial Synapse for Neuromorphic Systems
Authors: Shen Guangyue , Zhuge Chenyu , Jiang Jiandong , Fu Yujun , Zheng Yiming , Qin Zhaoyang , Wang Qi , He Deyan 
Published: September 2023

AbstractNeuromorphic computing inspired by memristors has gained considerable attention due to its low power and easy integration. However, state‐of‐the‐art two‐terminal resistive switching memristors based on conductive filament formation suffer from high variability and poor controllability. As a three‐terminal device operated through electrochemistry and dynamic insertion/extraction of ions, the electrochemical ion synapse demonstrates deterministic control of electron conductivity based on ion doping. But, integrating the electrochemical ion synapse into crossbar arrays will pose higher challenges and lower integration density. Herein, inspired by first‐principles calculations, a two‐terminal bidirectional plasticity electrochemical artificial synapse with integrated lithium polymer electrolyte and polycrystalline tungsten oxide layer is reported. The linearity and stability of the device weight update are greatly improved by adjusting the defect concentration of the polycrystalline WO3 layer. Even after 16 000 write‐read events in the air, its performance remained almost unchanged. Moreover, it has an over‐limit protection mechanism under one‐way stimulation that exceeds the normal range. Based on this excellent stability, the authors designed and successfully simulated the “muscle memory” that the programmatical organization of the nervous system leads to proficiency in specific actions.
Ultra Rate‐Dependent Pressure Sensitive Adhesives Enabled by Soft Elasticity of Liquid Crystal Elastomers
Authors: Annapooranan Raja , Suresh Jeyakumar Sunil , J. Chambers Robert , Long Rong , Cai Shengqiang 
Published: September 2023

AbstractThe fabrication of pressure sensitive adhesives (PSAs) using liquid crystal elastomers (LCEs), which are known for their excellent dissipation properties, is explored in this work. The adhesive properties of the PSAs are evaluated using the 180° peeling test at various conditions. The performance of the LCE adhesives is found to show significant rate and temperature dependence. When the adhesion energy is plotted against the rate, LCE shows an anomalously large power law exponent (n ≈ 1.17) compared to existing PSAs (n ≈ 0.1–0.6). The unusual rate sensitivity is hypothesized to originate from the synergy of soft elasticity and non‐linear viscoelasticity. The adhesive properties at various rates and temperatures are correlated to the results from dynamic mechanical analysis. Moreover, the large strain stiffening behavior of LCE under uniaxial tension reveals the distinctive advantages offered by LCE as adhesives. Time‐temperature superposition is used to obtain a master curve of adhesion energy that spans rates beyond typical experimental limits. The extreme rate dependence and the large strain stiffening of LCE yield a new category of adhesives that possess special properties, such as reversible adhesion and impact resistance, unlike traditional adhesives.
Multifunctional Thermoelectric Temperature Sensor for Noncontact Information Transfer and Tactile Sensing in Human‐Machine Interaction
Authors: Gao Fu‐Lin , Min Peng , Ma Qian , Zhang Tingting , Yu Zhong‐Zhen , Shang Jie , Li Run‐Wei , Li Xiaofeng 
Published: September 2023

AbstractUsing sensing devices for noncontact information transfer enhances data security in human‐machine interaction by eliminating direct contact between the information carrier and the communication interface. However, current contactless information transfer strategies struggle with complex application scenarios due to limitations in sensing mechanisms. Here, this work proposes an innovative noncontact information transfer approach that leverages invisible thermal radiation and the Seebeck effect, and demonstrates its feasibility by designing a high‐resolution temperature sensor based on a laminar thermoelectric aerogel of carbon nanotube/PEDOT:PSS/nanocellulose. The sensor exhibits exceptional sensitivity, ultralow detection limits (0.02 K), rapid response time, and reliable cycling stability in temperature detection without interference from pressure stimuli. This work further presents a sensor array‐based communication interface capable of extracting, decoding, and transmitting high‐capacity encrypted information contactlessly. The interface also serves as a contactless input terminal for precisely monitoring finger movements. Additionally, the sensor can convert pressure into resistance signals, functioning as tactile electronic skin in contact scenarios. This study presents a dependable strategy for transmitting information without physical contact, contributing to the development of future integrated devices.
Single‐Molecule Dendritic MRI Nanoprobes Reveal the Size‐Dependent Tumor Entrance
Authors: Ren Huiming , Hu Qiuhui , Yang Jiajia , Zhou Xiaoxuan , Liu Xiangrui , Tang Jianbin , Hu Hongjie , Shen Youqing , Zhou Zhuxian 
Published: September 2023

AbstractThe tumor entrance of drug delivery systems, including therapeutic proteins and nanomedicine, plays an essential role in affecting the treatment outcome. Nanoparticle size is a critical but contradictory factor in making a trade‐off among blood circulation, tumor accumulation, and penetration. Here, this work designs a series of single‐molecule gadolinium (Gd)‐based magnetic resonance imaging (MRI) nanoprobes with well‐defined sizes to precisely explore the size‐dependent tumor entrance in vivo. The MRI nanoprobes obtained by divergent synthesis contain a core molecule of macrocyclic Gd(III)‐chelate and different layers of dendritic lysine units, mimicking globular protein. This work finds that the r1 relaxivity and MR imaging signals increase with the nanoparticle size. The nanoprobe with a lower limit of critical size threshold ≈8.0 nm achieves superior tumor accumulation and penetration. These single‐molecule MRI nanoprobes can be served to precisely examine the size‐related nanoparticle‐biological interactions.
Self‐Adaptive Nanoregulator to Mitigate Dynamic Immune Evasion of Pancreatic Cancer
Authors: Pan Jiaxing , Lai Yi , Zhang Shunan , Zhang Huijuan , Shan Yiming , Huang Lujia , Wang Feng , Yu Haijun , Xu Leiming , Xu Zhiai 
Published: September 2023

AbstractThe advance of immunotherapy has shifted the paradigm of cancer management in clinics. Nevertheless, a considerable subset of pancreatic ductal adenocarcinoma (PDAC) patients marginally respond to current immunotherapy due to the occurrence of dynamic immune evasion arising from intrinsic and therapeutic stress. In this investigation, the pivotal role of pancreatic cancer‐associated fibroblast (CAF)‐induced fibrosis and tumor cell‐mediated T‐cell exhaustion in driving the dynamic immune evasion is identified. Building upon this discovery, the authors herein engineer a novel peptide‐drug conjugate (PDC)‐based self‐adaptive nanoregulator for mitigating dynamic immune evasion of PDAC. The resulting nanoregulator can perform a two‐stage morphology transformation from spherical micelle to nanofiber, and subsequently from nanofiber to spherical nanoparticles. Such kind of nanostructure design can facilitate differentialized delivery of CAF inhibitor in the extracellular matrix for intervening CAF‐mediated tumor fibrosis, and indoleamine 2,3‐dioxygenase 1 inhibitor to tumor cells for relieving IDO1‐kynurenine axis‐induced T‐cell exhaustion. Antitumor study with the self‐adaptive nanoregulator elicited persistent antitumor immunity and remarkable antitumor performance in both Panc02 and KPC tumor models in vivo. Taken together, the PDC‐based self‐adaptive nanoregulator may provide a novel avenue for enhanced PDAC immunotherapy.
Organic Electronics Circuitry for In Situ Real‐Time Processing of Electrophysiological Signals
Authors: De Salvo Anna , Rondelli Federico , Di Lauro Michele , Tomassini Alice , Greco Pierpaolo , Stieglitz Thomas , Fadiga Luciano , Biscarini Fabio 
Published: September 2023

AbstractThe next generation of brain–machine interfaces are envisioned to couple signal transduction, filtering, and sorting on board with minimum power consumption and maximum bio‐integrability. These functional needs shall be mandatorily met in order to design efficient closed‐loop brain–machine interfaces aimed at treating and monitoring various disorders of the central and peripheral nervous system. Here, the pivotal role is highlighted that organic bioelectronics may have in the contextual development of all these three desiderata, by demonstrating a modular organic‐electronics circuit toward real‐time signal filtering. The inherent filtering capabilities of electrolyte‐gated organic transistor are tuned via adjustment of operational conditions and benchmarked in an electromyography experiment. Additionally, a whole‐organic signal processing circuitry is presented, coupling such transistors with ad hoc designed organic passive components. This provides the possibility to sort complex signals into their constitutive frequency components in real time, thereby delineating innovative strategies to devise organic‐based functional building‐blocks for brain–machine interfaces.
Catalyst‐Controlled Divergent C3/C5 Site‐Selective C−H Arylation of 2‐Pyridylthiophenes
Authors: Huang Xuecong , Zhou Pengfei , Yang Xingdong , Wang Ruiyi , Huang Guan , Liang Taoyuan , Zhang Zhuan 
Published: September 2023

AbstractThe development of a rational protocol to realize the complete regioselectivity and the capability to switch regioselectivity is an appealing yet challenging task. Herein, a regiodivergent C−H arylation of 2‐pyridylthiophenes has been demonstrated via the choice of RuII and PdII catalysts. The reactions proceeded smoothly in a good regioselective manner to afford the corresponding C3‐ and C5‐arylated thiophenes. Late‐stage diversification of biologically relevant scaffold derived from estrone and successful transformation of the products further highlighted the potential utility and importance of this synthetic strategy.
DABCO‐Promoted Selective Photochemical C−N Coupling: Access to Unsymmetrical Azahelicenes
Authors: Balakhonov R. Yu. , Mekeda I. S. , Shirinian V. Z. 
Published: September 2023

AbstractA multifaceted study on the effect of various factors on the efficiency of photocyclization of naphthofuran O‐acyl oximes was performed. It showed that without any additives or in the presence of electron acceptors, the reaction occurs by a radical pathway and with low chemoselectivity, while DABCO promotes intramolecular cyclization to give naphthofuroquinolines (NFQs) in 34–87% yields. The iminyl radical formed under UV irradiation in the presence of DABCO due to single electron transfer (SET) and N−O bond cleavage undergoes selective intramolecular homolytic aromatic substitution (HAS) with formation of a new C−N bond. This route to quinoline‐annulated scaffolds is based on the use of DABCO both as an electron transfer agent and a proton acceptor.
Discovery of Anti‐CD47 Peptides as Innate Immune Checkpoint Inhibitors
Authors: Mustafa Bahaa , Fetse John , Kandel Sashi , Lin Chien‐Yu , Adhikary Pratik , Mamani Umar‐Farouk , Liu Yanli , Ibrahim Mohammed Nurudeen , Alahmari Mohammed , Cheng Kun 
Published: September 2023

AbstractCancer immunotherapy targeting adaptive immune cells has been attracting considerable interest due to its great success in treating multiple cancers. Recently, there is also increasing interest in agents that can stimulate innate immune cell activities. Immune checkpoint inhibitors targeting innate immune cells can block inhibitory interactions (“don't eat me” signals) between tumor cells and phagocytes. CD47 is a transmembrane protein overexpressed in various cancers and acts as a potent “do not eat me” signal that contributes to the immune evasion of cancer cells. Anti‐CD47 peptides that can bind to CD47 and block its interaction with signal regulatory protein alpha (SIRPα) are discovered using a novel phage display biopanning strategy. Anti‐CD47 peptides enhance the macrophage‐mediated phagocytosis of NCI‐H82 tumor cells in vitro. Unlike anti‐CD47 antibodies, these peptides do not induce the agglutination of red blood cells. Moreover, anti‐CD47 peptides exhibit high specificity for MC‐38 cancer cells expressing CD47. CMP‐22 peptide show the ability to increase the antitumor activity of doxorubicin and extends the survival of CT26 tumor‐bearing mice. The discovered anti‐CD47 peptides can be considered potential candidates for cancer immunotherapy by blocking the CD47/SIRPα interaction, especially in combination with chemotherapy, to elicit synergistic effects.
Tumor Microenvironment‐Related Sonodynamic Therapy Mediates Tumor Therapy
Authors: Wang Xiaodong , Wang Chunyue , Tian Huimin , Wu Bolin , Cheng Wen 
Published: September 2023

AbstractSonodynamic therapy (SDT) is a rapidly developing, safe, and noninvasive method for tumor treatment. SDT relies on ultrasound to stimulate the activity of sonosensitizers, induce the production of many reactive oxygen species (ROS), and mediate tumor cell death. The complex tumor microenvironment (TME) is the basis of tumorigenesis and tumor development. The characteristics of the TME, which are different from those of normal tissue, are essential factors in regulating the response to antitumor therapy. The therapeutic effect of SDT is affected by the TME. Therefore, the study of multifunctional sonosensitizers related to the TME is a future direction to enhance the efficacy of SDT in treating tumors. This review summarizes the characteristics of the TME, the factors that regulate it, and its role in regulating the response to sonosensitizers. It introduces strategies for enhancing the therapeutic effect of SDT by exploiting the TME and highlights the prospects of combination therapy for tumors based on the characteristics of the TME. With this paper, it is hoped to provide a research direction for improving the therapeutic effect of SDT and promoting its clinical translation in the future.
Exploring factors influencing repeated recalls in the US meat and poultry industry
Authors: Yu Jianbin , Hooker Neal H. 
Published: September 2023

AbstractRepeated recalls are an important issue impacting public health and the food industry. Survival functions are used to investigate the timing of repeated recalls and double hurdle regression models explore factors influencing the probability of repeated recalls and the number of repeated recalls in the US meat and poultry industry between 2003 and 2019. Findings suggest that 25% of recalls are repeated and the average period between recalls is 1340 days (3.67 years). Kaplan–Meier survival analysis results suggest that the number of repeats and similar reasons for recalls significantly impact survival functions but no statistically significant differences were seen across plant sizes. Regression results suggest that product type (processed vs. fresh products) had no significant impact on the probability of a repeated recall but a significant positive impact on the number of repeats. Extraneous material contamination positively influenced the probability of a repeated recall but negatively influenced the number of repeats. The scope of marketing (depth and breadth) had a significant positive impact on the probability of a repeated recall but had no significant impact on the number of repeats. Large plants are more likely to experience a repeated recall and a greater number of repeats. Considering market failures in the provision of safe food, government detection is an important way to discover food safety problems. The results show that government detection of problems is effective in reducing the probability of a repeated recall and the number of repeats. Based on these findings, we draw policy and management implications for the government and plants to avoid repeated recalls. [EconLit Citations: M11, Q13].
Dynamics of energy and biofuel markets in the context of rising oil prices
Authors: Zhang Chi 
Published: September 2023

AbstractRising fossil energy prices have sparked interest in biofuels, which has led to a closer link between biofuels and fossil energy markets. We apply a thermal optimal path approach based on daily returns to examine the lead‐lag correlation between three biomass futures and three energy futures for 2020–2022. The empirical results show that the biomass futures market first leads the energy futures market with a significant probability of 20–30 days. Second, the lead days decrease sharply after regional conflicts occur, and the link between the two markets strengthens. Third, the sequence of risk transmission between overseas and domestic energy markets changes, and domestic energy markets become more resilient. Finally, the epidemic disrupted the normal transmission of signals between markets, while regional conflicts reconstructed the links, and the transmission time was shorter. In the post‐Covid‐19 period, ongoing conflicts have synchronized risks between markets, further amplifying the possibility of crises.
Cu2+‐Anchored Carbon Nano‐Photocatalysts for Visible Water Splitting to Boost Hydrogen Cuproptosis
Authors: Ding Haizhen , Ren Fangfang , Liu Peifei , Feng Yushuo , Ma Xiaoqian , Shen Zhiyang , Shi Qianqian , Xu Mengjiao , Li Wenle , Chen Hongmin 
Published: September 2023

AbstractBoth hydrogen (H2) and copper ions (Cu+) can be used as anti‐cancer treatments. However, the continuous generation of H2 molecules and Cu+ in specific sites of tumors is challenging. Here we anchored Cu2+ on carbon photocatalyst (Cu@CDCN) to allow the continuous generation of H2 and hydrogen peroxide (H2O2) in tumors using the two‐electron process of visible water splitting. The photocatalytic process also generated redox‐active Cu‐carbon centers. Meanwhile, the Cu2+ residues reacted with H2O2 (the obstacle to the photocatalytic process) to accelerate the two‐electron process of water splitting and cuprous ion (Cu+) generation, in which the Cu2+ residue promoted a pro‐oxidant effect with glutathione through metal‐reducing actions. Both H2 and Cu+ induced mitochondrial dysfunction and intracellular redox homeostasis destruction, which enabled hydrogen therapy and cuproptosis to inhibit cancer cell growth and suppress tumor growth. Our research is the first attempt to integrate hydrogen therapy and cuproptosis using metal‐enhanced visible solar water splitting in nanomedicine, which may provide a safe and effective cancer treatment.
Schiff Base Reaction in a Living Cell: In Situ Synthesis of a Hollow Covalent Organic Polymer To Regulate Biological Functions
Authors: Xu Han‐Bin , Chen Hua‐Ying , Lv Jian , Chen Bin‐Bin , Zhou Ze‐Rui , Chang Shuai , Gao Ya‐Ting , Huang Wen‐Fei , Ye Ming‐Jie , Cheng Zi‐Jian , Hafez Mahmoud Elsayed , Qian Ruo‐Can , Li Da‐Wei 
Published: September 2023

AbstractArtificially performing chemical reactions in living biosystems to attain various physiological aims remains an intriguing but very challenging task. In this study, the Schiff base reaction was conducted in cells using Sc(OTf)3 as a catalyst, enabling the in situ synthesis of a hollow covalent organic polymer (HCOP) without external stimuli. The reversible Schiff base reaction mediated intracellular Oswald ripening endows the HCOP with a spherical, hollow porous structure and a large specific surface area. The intracellularly generated HCOP reduced cellular motility by restraining actin polymerization, which consequently induced mitochondrial deactivation, apoptosis, and necroptosis. The presented intracellular synthesis system inspired by the Schiff base reaction has strong potential to regulate cell fate and biological functions, opening up a new strategic possibility for intervening in cellular behavior.
A prospective study on single‐port versus multiport patient‐reported surgical outcomes
Authors: Morgantini Luca A. , Alzein Ahmad , Bharadwaj Arthi , del Pino Matthew S. , Egan Erin , Ganesh Ashwin , Smith John , Crivellaro Simone 
Published: September 2023

AbstractIntroductionWe sought to determine potential patient reported advantages of the da Vinci single‐port (SP) robotic system for urological procedures compared with the previous model, the da Vinci multiport (MP) system. The SP model utilizes a single 30 to 40 mm incision rather than multiple 5 to 22 mm incisions. This project aims to prospectively investigate the impact of the novel SP system on patient reported cosmetic and psychometric surgical outcomes.MethodsWe conducted a prospective study of patients who underwent uro‐oncologic surgery by three urologists at the University of Illinois Chicago from April to November 2021. Study participants completed a Patient Scar Assessment Questionnaire 20 and 90 days post‐procedure. The Patient Scar Assessment Questionnaire is a reliable measure of surgical scars that includes five subscales: Appearance, Symptoms, Consciousness, Satisfaction with Appearance, and Satisfaction with Symptoms. Higher scores represented worse reported outcomes.ResultsOn Postoperative Day 20, there were 77 responses (53 SP and 24 MP). Patients receiving SP procedures reported more favourable outcomes in terms of appearance, symptoms, consciousness, and pain medication. On Day 90, there were 37 responses (24 SP and 13 MP). Patients receiving SP procedures reported more favourable outcomes in terms of appearance. No significant differences were seen on Day 90 in terms of pain, medication, symptoms, consciousness, or satisfaction.ConclusionsThis study demonstrates the superiority of the SP in patient reported cosmetic and pain outcomes on short‐ and long‐term follow‐up after uro‐oncological surgical procedures. Symptomatic and cosmetic advantages are present at the 20 day follow‐up, with better scar appearance being significant 90 days after surgery.