bluuebunny/crossref_metadata_2025_split huggingface dataset:
Redesign Website Sistem Informasi Teknik Elektro UNG Melalui Pendekatan Human Centered Design
Authors: Prayoga Syahrul Aji , Dako Rahmat Deddy Rianto , Ridwan Wrastawa 
Published: July 2023

Skor pengujian usabilitas pada website Sistem Informasi Teknik Elektro Universitas Negeri Gorontalo yang diuji dengan metode System Usability Scale (SUS) hanya berada pada skor 57,5. Pada kategori Acceptability Range berada pada tingkat marginal, sedangkan pada kategori Adjective Ratings berada pada tingkat OK, dan kategori Grade Scale pada skala D. Berdasarkan rendahnya skor usabilitas tersebut, maka dilakukan redesign menggunakan pendekatan Human Centered Design (HCD). Tujuan dilakukannya redesign ini adalah untuk meningkatan skor usabilitas pada website tersebut. Setelah dilakukan redesign menggunakan pendekatan Human Centered Design (HCD) dan pengujian menggunakan metode System Usability Scale (SUS) diperoleh skor usabilitas pada skor 73,5. Skor tersebut sudah masuk dalam tingkat Acceptable pada kategori Acceptability Range, pada kategori Adjective Ratings berada pada tingkat Good dan Grade Scale pada tingkatan B. Terlihat bahwa setelah dilakukan redesign terjadi peningkatan skor usabilitas, sehingga website Sistem Informasi Teknik Elektro Universitas Negeri Gorontalo dapat diklasifikasikan sebagai “above average” sesuai dengan minimal skor menurut Jeff Sauro. The usability test score on the website of the Electrical Engineering Information System of Universitas Negeri Gorontalo, which was tested using the System Usability Scale (SUS) method, was only at a score of 57,5. The Acceptability Range category is at the marginal level, while the Adjecive Rating category is at the OK level, and the Grade Scale category is on a D scale. based on the low usability score, a redesign was carried out using the Human Centered Design (HCD) approach. This redesign aims to increase the usability score on the website. After redesigning using the Human Centered Design (HCD) approach and testing using the System Usability Scale (SUS) method obtained a usability score of 73,5. This score is included in the Acceptable level in the Acceptability Range category. The Adjective Ratings category is at the Good level, and the Grade Scale is at level B. Therefore, it is confirmed that after the redesign, there is an increase in the usability score, so the website of the Electrical Engineering Information System of Universitas Negeri Gorontalo can be classified as “above average” based on the minimum score according to Jeff Sauro.
Partisanship and performance of youth leaders in the Philippines
Authors: Valencia Ma. Sarah Fatima P. 
Published: July 2023

This study was designed to determine the partisanship and performance of youth leaders locally known as Sangguniang Kabataan (SK) officials in the Second District of Negros Oriental, Philippines. This study also aimed to determine the profile of the youth leaders and the extent of partisanship before and after the election. There were 153 youth leaders who participated in the study. The descriptive research design with the quantitative method of data gathering was utilized. The questionnaire was the primary data-gathering tool triangulated with focus group discussions and interviews.
Based on the data collated, the following findings were revealed: The majority of the youth leaders are aged 22 - 26 years old, males, single, studying in college, receive a monthly honorarium of P 5,001 - 6,000, and do not have any official political party. There is a high extent of partisanship before and after the election. The programs implemented were focused on equitable access to education, environmental protection, climate change, youth employment and livelihood, health, anti-drug abuse, gender sensitivity, sports development, and capability building. The youth leaders have high performance in the programs focusing on sports development, anti-drug abuse, environmental protection, and health. On the other hand, the programs on climate change, equitable access to education, gender sensitivity, and youth employment and livelihood are rated “moderate”.
PENERAPAN METODE PEMBELAJARAN ROLE PLAY UNTUK MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR KETRAMPILAN BERBICARA BAHASA INGGRIS
Authors: Hakim Lukman 
Published: July 2023

The aim of this research is to improve learning outcomes of speaking ability and response in English through “Role Play” in SMPM 27 Paciran Lamongan. The subject of the research is grade IX students of the first semester in the academic year of 2020/2021 consisting of 21 pupils. To collect the data, the researcher uses observation sheet and the result of speaking test. The research proses was conducted into two cycles, each cycle consisting of four phases : preparation, implementation, obeservation and reflection. The findings of the research show that Role Play method is effective to improve the students’ activities and the result of speaking test. From the result of the analysis showed that there is an increase of students’ activities in cycle 1 from 76% into 88% on second cycle. The result of speaking test in English increase from the completeness of learning from 57% in cycle 1 into 81% in cycle 2.

Key words : Speaking Ability, Learning Activity, Role Play, Learning Outcome.

Abstrak : Tujuan Penelitian ini adalah untuk meningkatkan hasil belajar berbicara dan respon siswa dalam Bahasa Inggris melalui metode pembelajaran “Role play” di SMP Muhammadiyah 27 Paciran Lamongan. Subyek penelitian ini adalah siswa kelas IX (Sembilan) pada semester satu tahun pelajaran 2020/2021 yang terdiri dari 21 siswa. Untuk mengumpulkan data, peneliti menggunakan lembar observasi dan hasil penampilan tes berbicara. Proses penelitian ini dilakukan dalam dua siklus terdiri dari empat tahap ; perencanaan, pelaksanaan, pengamatan dan refleks. Penemuan dalam pengamatan ini menunjukkan bahwa metode Role Play efektif untuk meningkatkan aktivitas siswa dan hasil tes berbicara. Dari hasil analisis menunjukkan ada peningkatan aktivitas siswa dari siklus satu 76% menjadi 88% di siklus dua. Hasil tes berbicara dalam bahasa Inggris meningkat dari ketuntasan belajar 57% pada siklus 1 menjadi 81% pada siklus 2.
Kata kunci : Kemampuan Berbicara, Aktivitas Belajar, Metode Role Play, Hasil Belajar.
АНАЛИЗ БЕЗОПАСНОСТИ МОДЕЛИ ФУНКЦИОНИРОВАНИЯ ОТКАЗОУСТОЙЧИВОЙ СИСТЕМЫ РЕЗЕРВНОГО ХРАНЕНИЯ КОНФИДЕНЦИАЛЬНЫХ ДАННЫХ
Authors: Тасмагамбетов Олжас , Сейткулов Ержан , Оспанов Руслан , Жүзбаев Серік , Ергалиева Бану 
Published: July 2023

Данная работа посвящена проблеме безопасности резервного хранения конфиденциальных данных в распределенных серверах. Для решения этой задачи существуют криптографические протоколы, обеспечивающие зашифрование сообщений, расшифрование которых будет возможно не ранее заданного времени. Такие протоколы представляют собой эффективную комбинацию различных вариантов протоколов распределенной генерации ключей, протоколов проактивного разделения секрета, асимметричных алгоритмов шифрования, алгоритмов электронной цифровой подписи. На основе таких криптографических протоколов можно разработать и внедрить практический сервис шифрования данных в распределенных серверах. Это одно из важных проблем в вопросах обеспечения безопасности функционирования критически важных информационных систем, оперирующие с большими объемами конфиденциальной информации. В работе проводится анализ безопасности модели функционирования отказоустойчивого сервиса децентрализованного хранения информации на основе современных криптографических протоколов шифрования.
Dementia Diagnosis and Alternate Treatment: A Recent Update on Treatment Options
Authors: Gupta Uma D. , Shafin Tasnuva Nuhat , Rahman Nuzhat , Chakraborty Elora , Deb Manisha , Ferdous Tahira 
Published: July 2023

Dementia is a global health burden identified by the World Health Organization in its global action plan on the public health response to dementia 2017-2025. Our study aims to determine the efficacy of treatment options in Alzheimer’s disease and related dementia (ADRD). The initiation of dementia treatment has consistently posed a significant dilemma for healthcare professionals, necessitating careful consideration when selecting the appropriate group of medications to commence therapy, considering the specific type of treatment required. To conduct our study, we searched PubMed Central and the Cochrane database to identify comparative trials that compared different dementia treatment options. Our objective was to evaluate the effectiveness of various treatment approaches across different types of dementia. In total, we reviewed over 40 papers that provided valuable insights into the comparative outcomes of these treatment options. In our analysis, we have found mild to moderate cognitive dysfunction (MMSE 19 to 26) and newly diagnosed Alzheimer's disease can be treated with a trial of Cholinesterase inhibitors (Donepezil, Galantamine, and Rivastigmine); choice can be based on clinician and/or patient preference, as efficacy is similar. Moderate to advanced dementia (MMSE 10 to 18): Memantine (10 mg twice daily) is a suggested option with Cholinesterase inhibitors. In conclusion, it is evident that the available options for dementia medication are inherently limited, while the resources allocated to evaluate further treatment alternatives remain constrained. As a result, there is an urgent need to prioritize additional research and comprehensive assessment in this field.
Screening for Lipid Disorders in Children and Adolescents
Authors: Guirguis-Blake Janelle M. , Evans Corinne V. , Coppola Erin L. , Redmond Nadia , Perdue Leslie A. 
Published: July 2023

ImportanceLipid screening in childhood and adolescence can lead to early dyslipidemia diagnosis. The long-term benefits of lipid screening and subsequent treatment in this population are uncertain.ObjectiveTo review benefits and harms of screening and treatment of pediatric dyslipidemia due to familial hypercholesterolemia (FH) and multifactorial dyslipidemia.Data SourcesMEDLINE and the Cochrane Central Register of Controlled Trials through May 16, 2022; literature surveillance through March 24, 2023.Study SelectionEnglish-language randomized clinical trials (RCTs) of lipid screening; recent, large US cohort studies reporting diagnostic yield or screen positivity; and RCTs of lipid-lowering interventions.Data Extraction and SynthesisSingle extraction, verified by a second reviewer. Quantitative synthesis using random-effects meta-analysis.Main Outcomes and MeasuresHealth outcomes, diagnostic yield, intermediate outcomes, behavioral outcomes, and harms.ResultsForty-three studies were included (n = 491 516). No RCTs directly addressed screening effectiveness and harms. Three US studies (n = 395 465) reported prevalence of phenotypically defined FH of 0.2% to 0.4% (1:250 to 1:500). Five studies (n = 142 257) reported multifactorial dyslipidemia prevalence; the prevalence of elevated total cholesterol level (≥200 mg/dL) was 7.1% to 9.4% and of any lipid abnormality was 19.2%. Ten RCTs in children and adolescents with FH (n = 1230) demonstrated that statins were associated with an 81- to 82-mg/dL greater mean reduction in levels of total cholesterol and LDL-C compared with placebo at up to 2 years. Nonstatin-drug trials showed statistically significant lowering of lipid levels in FH populations, but few studies were available for any single drug. Observational studies suggest that statin treatment for FH starting in childhood or adolescence reduces long-term cardiovascular disease risk. Two multifactorial dyslipidemia behavioral counseling trials (n = 934) demonstrated 3- to 6-mg/dL greater reductions in total cholesterol levels compared with the control group, but findings did not persist at longest follow-up. Harms reported in the short-term drug trials were similar in the intervention and control groups.Conclusions and RelevanceNo direct evidence on the benefits or harms of pediatric lipid screening was identified. While multifactorial dyslipidemia is common, no evidence was found that treatment is effective for this condition. In contrast, FH is relatively rare; evidence shows that statins reduce lipid levels in children with FH, and observational studies suggest that such treatment has long-term benefit for this condition.
A Cyclodextrin‐Based pH‐Responsive MicroRNA Delivery Platform Targeting Polarization of M1 to M2 Macrophages for Sepsis Therapy
Authors: Ding Ni , Luo Gangjian , Li Huiting , Xing Chengyuan , Gao Yuanji , Xi Wenjie , Wu Weijie , Wang Dan , Zheng Lei , Kang Yang , Chi Xinjin 
Published: July 2023

AbstractThe mortality rate of sepsis remains high despite improvements in the diagnosis and treatment of sepsis using symptomatic and supportive therapies, such as anti‐infection therapy and fluid resuscitation. Nucleic acid‐based drugs have therapeutic potential, although their poor stability and low delivery efficiency have hindered their widespread use. Herein, it is confirmed that miR‐223 can polarize proinflammation M1 macrophages to anti‐inflammation M2 macrophages. A pH‐sensitive nano‐drug delivery system comprising β‐cyclodextrin‐poly(2‐(diisopropylamino)ethyl methacrylate)/distearoyl phosphoethanolamine‐polyethylene glycol (β‐CD‐PDPA/DSPE‐PEG) is synthesized and developed to target M1 macrophages and miR‐223 is encapsulated into nanoparticles (NPs) for sepsis treatment. NPs/miR‐223 demonstrated in vitro pH responsiveness with favorable biosafety, stability, and high delivery efficiency. In vivo studies demonstrate that NPs/miR‐223 are preferentially accumulated and retained in the inflammation site, thereby reducing inflammation and improving the survival rate of mice with sepsis while exhibiting ideal biosafety. Mechanically, NPs/miR‐223 regulates macrophage polarization by targeting Pknox1 and inhibiting the activation of the NF‐κB signaling pathway, thereby achieving an anti‐inflammatory effect. Collectively, it is demonstrated that the miRNA delivery vector described here provides a new approach for sepsis treatment and accelerates the advancement of nucleic acid drug therapy.
X‐Ray Nanothermometry of Nanoparticles in Tumor‐Mimicking Tissues under Photothermia
Authors: López‐Méndez Rosalía , Reguera Javier , Fromain Alexandre , Serea Esraa Samy Abu , Céspedes Eva , Teran Francisco Jose , Zheng Fangyuan , Parente Ana , García Miguel Ángel , Fonda Emiliano , Camarero Julio , Wilhelm Claire , Muñoz‐Noval Álvaro , Espinosa Ana 
Published: July 2023

AbstractTemperature plays a critical role in regulating body mechanisms and indicating inflammatory processes. Local temperature increments above 42 °C are shown to kill cancer cells in tumorous tissue, leading to the development of nanoparticle‐mediated thermo‐therapeutic strategies for fighting oncological diseases. Remarkably, these therapeutic effects can occur without macroscopic temperature rise, suggesting localized nanoparticle heating, and minimizing side effects on healthy tissues. Nanothermometry has received considerable attention as a means of developing nanothermosensing approaches to monitor the temperature at the core of nanoparticle atoms inside cells. In this study, a label‐free, direct, and universal nanoscale thermometry is proposed to monitor the thermal processes of nanoparticles under photoexcitation in the tumor environment. Gold‐iron oxide nanohybrids are utilized as multifunctional photothermal agents internalized in a 3D tumor model of glioblastoma that mimics the in vivo scenario. The local temperature under near‐infrared photo‐excitation is monitored by X‐ray absorption spectroscopy (XAS) at the Au L3‐edge (11 919 eV) to obtain their temperature in cells, deepening the knowledge of nanothermal tumor treatments. This nanothermometric approach demonstrates its potential in detecting high nanothermal changes in tumor‐mimicking tissues. It offers a notable advantage by enabling thermal sensing of any element, effectively transforming any material into a nanothermometer within biological environments.
DNA‐Programmed Stem Cell Niches via Orthogonal Extracellular Vesicle–Cell Communications
Authors: Wang Kaizhe , Wei Yuhan , Xie Xiaodong , Li Qian , Liu Xiaoguo , Wang Lihua , Li Jiang , Wu Ji , Fan Chunhai 
Published: July 2023

AbstractExtracellular vesicles (EVs) are natural carriers for intercellular transfer of bioactive molecules, which are harnessed for wide biomedical applications. However, a facile yet general approach to engineering interspecies EV–cell communications is still lacking. Here, the use of DNA to encode the heterogeneous interfaces of EVs and cells in a manner free of covalent or genetic modifications is reported, which enables orthogonal EV–cell interkingdom interactions in complex environments. Cholesterol‐modified DNA strands and tetrahedral DNA frameworks are employed with complementary sequences to serve as artificial ligands and receptors docking on EVs and living cells, respectively, which can mediate specific yet efficient cellular internalization of EVs via Watson–Crick base pairing. It is shown that based on this system, human cells can adopt EVs derived from the mouse, watermelon, and Escherichia coli. By implementing several EV–cell circuits, it shows that this DNA‐programmed system allows orthogonal EV–cell communications in complex environments. This study further demonstrates efficient delivery of EVs with bioactive contents derived from feeder cells toward monkey female germline stem cells (FGSCs), which enables self‐renewal and stemness maintenance of the FGSCs without feeder cells. This system may provide a universal platform to customize intercellular exchanges of materials and signals across species and kingdoms.
Mechanochromic Response of Spiropyran‐Incorporated Liquid Crystalline Elastomer Network and the Mechanochromic Enhancement by Nano Zinc Oxide
Authors: Han Dongxu , Wang Xiuxiu , Liu Shiyu , Zhang Yuhe , Li Chensha , Gao Yachen , Zhang Jianqi 
Published: July 2023

AbstractSpiropyran (SP) based mechanochromic systems are intensively interesting in the research area of mechanochromic materials. Herein, an SP mechanophore is chemically incorporated into a liquid crystalline elastomer (LCE) network through Michael addition. The rigidity of mesogens and the orientation of polymer main chains, in which the aligned mesogens and SP moieties are covalently attached, facilitate the transduction of applied force to SP mechanophore to trigger mechanochromic reaction. The LCE network provides enough elasticity for mechanochromic activation. The obtained SP‐LCEs demonstrate strong and reversible mechanochromic response upon mechanical compression. The mechanochromic efficiency and sensitivity are substantially enhanced by doping the SP‐LCE matrix with nano zinc oxide such that it is easy to write on the material surface by using a thin iron wire. The authors hope such SP‐LCE materials will be further developed for real‐time stress detection applications.
Measuring Sentence Information via Surprisal: Theoretical and Clinical Implications in Nonfluent Aphasia
Authors: Rezaii Neguine , Michaelov James , Josephy‐Hernandez Sylvia , Ren Boyu , Hochberg Daisy , Quimby Megan , Dickerson Bradford C. 
Published: July 2023

ObjectiveNonfluent aphasia is characterized by simplified sentence structures and word‐level abnormalities, including reduced use of verbs and function words. The predominant belief about the disease mechanism is that a core deficit in syntax processing causes both structural and word‐level abnormalities. Here, we propose an alternative view based on information theory to explain the symptoms of nonfluent aphasia. We hypothesize that the word‐level features of nonfluency constitute a distinct compensatory process to augment the information content of sentences to the level of healthy speakers. We refer to this process as lexical condensation.MethodsWe use a computational approach based on language models to measure sentence information through surprisal, a metric calculated by the average probability of occurrence of words in a sentence, given their preceding context. We apply this method to the language of patients with nonfluent primary progressive aphasia (nfvPPA; n = 36) and healthy controls (n = 133) as they describe a picture.ResultsWe found that nfvPPA patients produced sentences with the same sentence surprisal as healthy controls by using richer words in their structurally impoverished sentences. Furthermore, higher surprisal in nfvPPA sentences correlated with the canonical features of agrammatism: a lower function‐to‐all‐word ratio, a lower verb‐to‐noun ratio, a higher heavy‐to‐all‐verb ratio, and a higher ratio of verbs in ‐ing forms.InterpretationUsing surprisal enables testing an alternative account of nonfluent aphasia that regards its word‐level features as adaptive, rather than defective, symptoms, a finding that would call for revisions in the therapeutic approach to nonfluent language production. ANN NEUROL 2023;94:647–657
A neuroanatomy lab practical exam format in alignment with the universal design for learning framework
Authors: Kimpo Rhea R. , Puder Barb 
Published: July 2023

AbstractThe traditional format for neuroanatomy lab practical exams involves stations with a time limit for each station and inability to revisit stations. Timed exams have been associated with anxiety, which can lead to poor performance. In alignment with the universal design for learning (UDL), Timed Image Question and Untimed Image Question exam formats were designed to determine which format supports student success, especially for those who performed poorly in the traditional format. Only the Untimed Image Question format allowed students to revisit questions. All three formats were administered in a randomized order within a course for three cohorts of medical students. When all students' scores were analyzed together, the type of format had no effect. However, when analyses were conducted only on students who performed poorly in the traditional format, the type of format had an effect. These students increased their score, on average, by at least one grade level in the Untimed Image Question format compared to the traditional format. Students who performed well in the traditional format maintained their A, on average, in the two new formats. More students indicated Untimed Image Question as their most preferred format after experiencing all three formats. Most students associated the inability to revisit questions with high levels of anxiety. A neuroanatomy lab exam format was therefore identified as consistent with the UDL framework such that all students, regardless of test anxiety levels, can equally demonstrate what they learned. This format allowed for unlimited time per question and ability to revisit questions.
Multistimuli‐responsive fluorescence behaviours of aggregation‐induced emission small‐molecule and electrospun nanofibre films for acid–base vapour sensing
Authors: Ma Chunping , He Jiyin , Wu Yancheng , Li Junlang , Chen Jiayi , Zhang Yangfan , Mo Jinpeng , Xie Haibo , Chi Zhenguo , Li Yang , Jin Yongcan 
Published: July 2023

AbstractMultistimuli‐responsive fluorescent materials have garnered great research interest benefited from their practical applications. Two twisted‐structure compounds containing tetraphenylethylene (TPE) as the aggregation‐induced emission (AIE) group and a pyridine unit as the acid reaction site to obtain new multistimuli‐responsive fluorescent compounds (namely, TPECNPy: TPECNPy‐2 and TPECNPy‐3) were successfully synthesized through a one‐step Knoevenagel condensation reaction. The multiple‐stimuli response process of TPECNPy was investigated by means of photoluminescence (PL) spectra and emission colour. The results showed that both TPECNPy compounds with excellent AIE abilities displayed reversible emission wavelength and colour changes in response to multiple external stimuli, including grinding–fuming by CH2Cl2 or annealing and HCl‐NH3 vapour fuming. More importantly, fluorescent nanofibre films were prepared by electrospinning a solution of TPECNPy mixed with cellulose acetate (CA), and these exhibited reversible acid‐induced discolouration, even with only 1 wt% TPECNPy. The results of this study may inspire strategies for designing multistimuli‐responsive materials and preparing fluorescent sensing nanofibre films.