bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Unified Predictability Test Using Weighted Inference and Random Weighted Bootstrap
Authors: Yang Bingduo , Long Wei , Liu Xiaohui , Peng Liang 
Published: January 2025

Abstract
Predictive regressions play a pivotal role in assessing the predictability of returns for financial assets. However, the existence of a non-zero intercept in the predictive variable poses challenges for the popular IVX method, as the statistical properties of a nearly integrated predictive variable differ significantly with and without an intercept. This article presents a novel unified predictability test utilizing weighted inference and random weighted bootstrap. It addresses challenges posed by both conditional heteroscedasticity in linear predictive regression and the presence of a non-zero intercept in the predictor variable. Simulation results demonstrate the accurate size of the proposed test across various scenarios, including stationary, near unit root, unit root, mildly integrated, mildly explosive, and zero and non-zero intercepts. In an empirical application, we employ the proposed test to investigate the predictive capacity of eleven economic and financial variables on the monthly returns of the S&P 500 from 1980 to 2019. The findings reveal stronger evidence of predictability compared to the instrumental variable-based test.
Head and neck paraganglioma in Pacak-Zhuang syndrome
Authors: Rosenblum Jared S , Cole Yasemin , Dang Danielle , Lookian Pashayar P , Alkaissi Hussam , Patel Mayank , Cappadona Anthony J , Jha Abhishek , Edwards Nancy , Donahue Danielle R , Munasinghe Jeeva , Wang Herui , Knutsen Russell H , Pappo Alberto S , Lechan Ronald M , Kozel Beth A , Smirniotopoulos James G , Kim H Jeffrey , Vortmeyer Alexander , Miettinen Markku , Heiss John D , Zhuang Zhengping , Pacak Karel 
Published: January 2025

Abstract

Background
Head and neck paragangliomas (HNPGLs) are typically slow-growing, hormonally inactive tumors of parasympathetic paraganglia. Inactivation of prolyl-hydroxylase domain-containing 2 protein causing indirect gain-of-function of hypoxia-inducible factor-2α (HIF-2α), encoded by EPAS1, was recently shown to cause carotid body hyperplasia. We previously described a syndrome with multiple sympathetic paragangliomas caused by direct gain-of-function variants in EPAS1 (Pacak-Zhuang syndrome, PZS) and developed a corresponding mouse model.

Methods
We evaluated a cohort of patients with PZS (n = 9) for HNPGL by positron emission tomography, magnetic resonance imaging, and computed tomography and measured carotid body size compared to literature reference values. Resected tumors were evaluated by histologic sectioning and staining. We evaluated the corresponding mouse model at multiple developmental stages (P8 and adult) for lesions of the head and neck by high resolution ex vivo imaging and performed immunohistochemical staining on histologic sections of the identified lesions.

Results
hree patients had imaging consistent with HNPGL, one of which warranted resection and was confirmed on histology. Three additional patients had carotid body enlargement (Z-score &gt; 2.0), and 3 had carotid artery malformations. We found that 9 of 10 adult variant mice had carotid body tumors and 6 of 8 had a paraganglioma on the cranio-caval vein, the murine homologue of the superior vena cava; these were also found in 4 of 5 variant mice at post-natal day 8. These tumors and the one resected from a patient were positive for tyrosine hydroxylase, synaptophysin, and chromogranin A. Brown fat in a resected patient tumor carried the EPAS1 pathogenic variant.

Conclusions
These findings (1) suggest HNPGL as a feature of PZS and (2) show that these pathogenic variants are sufficient to cause the development of these tumors, which we believe represents a continuous spectrum of disease starting from hyperplasia.
Caregiver food allergy self-efficacy explains the relationship between perceived food allergy severity and burden
Authors: Barber Maegan , Griffin Danielle , Neshkes Rebecca , Kichline Tiffany , Sigel Sabrina , Herbert Linda Jones 
Published: January 2025

Abstract

Objective
Caregiver perceived food allergy severity is associated with food allergy burden, while caregiver food allergy self-efficacy has been linked to improved quality of life for caregivers. This study examined the mediating effect of caregiver food allergy self-efficacy on the relationship between perceived food allergy severity and caregiver food allergy burden.

Methods
Caregivers of children diagnosed with IgE-mediated food allergy were recruited from pediatric allergy clinics to complete demographic and medical questionnaires, the Food Allergy Independent Measure-Parent Form, the Food Allergy Self-Efficacy Scale for Parents, and the Food Allergy Quality of Life-Parental Burden. Hayes’ PROCESS was utilized to test mediation analysis. The TREND checklist is available in the Supplementary Materials section.

Results
Analyses consisted of 94 caregivers of children (Mage = 11.72 years, 52.7% male, 34.0% Black). Caregiver food allergy self-efficacy mediated the relationship between perceived food allergy severity and caregiver food allergy burden, B = 0.16, SE = 0.07, CI (0.04–0.33).

Conclusions
Caregiver food allergy self-efficacy may play an important role in food allergy psychosocial functioning. Interventions targeting self-efficacy could reduce caregiver food allergy burden. Future research should explore additional psychosocial and medical factors to better tailor food allergy interventions to the family’s unique needs.
Laparoscopic resection of an isolated iliac artery aneurysm with synthetic graft implantation
Authors: Kang Taifen , Huang Weihua , Li Yi , Zhong Guangyao , Zhang Hong 
Published: January 2025

Abstract
The current treatment options for isolated iliac artery aneurysm (IIAA) are mainly endovascular treatment (ET) and open surgery. ET carries risks such as endoleaks and stent displacement, while open elective surgical repair of IIAAs carries significant risk of mortality. Therefore, this report presents a case of laparoscopic surgery for IIAA, providing a new approach for treating IIAA. Under laparoscopic guidance, the IIAA was resected, and an artificial graft was implanted to complete the surgery. At 6 months follow-up, the patient remained well, and the artificial graft was patent.
Stepchildren in succession law across European jurisdictions – current landscape and legislative concerns
Authors: Miler Dorota 
Published: January 2025

Abstract
In many European countries, over 10 per cent of families are blended families. However, national succession laws often do not recognize the factual relationships existing within blended families. Only a few jurisdictions grant children rights to their parent’s spouse’s or unmarried partner’s estate. This article identifies and groups the relevant provisions. An analysis of the provisions shows that stepchildren and children of an unmarried partner have very limited succession-law rights, and nowhere in Europe do they have rights equal to those of legitimate children. To facilitate a change, this article identifies and examines the aspects to be considered when legislating succession-law rights for children in blended families.
(Un)usual spaces of refuge? The viewer’s perspective and the politics of knowledge on refugee-hosting geographies
Authors: Fakhoury Tamirace 
Published: January 2025

Abstract
Refugee-hosting geographies represent complex sites of encounter where power and knowledge intersect with territoriality. While they cannot be inherently ‘unusual’, they become so when they deviate from dominant discourses, categories and practices that seek to impose order and meaning within the global refugee regime. The introduction to the Special Issue sets the stage for the collection of papers by conceptualizing (un)usual spaces of refuge. It explores how complex entanglements between policy and knowledge production cast certain geographies of refuge as ‘unusual’, obscuring their role, relevance, and challenges within the global refugee regime. Drawing on perspectives from critical geopolitics, refugee studies and international relations, the collection seeks to achieve three aims. First, it pluralizes perspectives on refugee-hosting geographies beyond the core and periphery and the North/South divide. Second, it calls for mapping everyday cartographies that reflect refugees’ experiences of placemaking. Third, it highlights how policy assumptions about ‘interim’ versus ‘preferred’ geographies can obscure understanding of how refugees perceive durable solutions and destinations beyond the ‘territorial trap’.
Photometric light curve studies: potential bias induced by exposure time
Authors: Liu Dezi , Fan Zuhui 
Published: January 2025

ABSTRACT
In photometric observations, the flux averaged over the preset exposure time is usually used as the representation of an object’s true flux at the middle of the exposure interval. For the study of transients and variables, it is also the default manner to build the light curves. In this work, we investigate the effect of this common practice on quantifying the photometric light curves. Our analysis shows that the flux averaged over the exposure time is not necessarily identical to the true flux so that potential bias may be introduced. The overall profile of the true light curve tends to be flattened by the exposure time. In addition, it is found that the peak position and photometric colour can also be altered. We then discuss the impacts of the bias induced by exposure time on the light curves of stellar flares, periodic stars, and active galactic nuclei (AGNs). The bias can lead to an underestimate of the total fluxes of stellar flares which has been noticed in the observational data. For periodic stars that follow a sinusoidal light curve, the bias does not affect the period and peak position, but can result in the peak flux being underestimated. Meanwhile, the bias can result in steeper structure function at short time-scales for AGN light curves. To obtain unbiased physical parameter estimates from the light curves, our analysis indicates that it is essential to account for this bias, particularly for transients and variables with very short time-scales.
Effects of regional variations and occupation on hand osteoarthritis: Insights from the research on osteoarthritis/osteoporosis against disability study
Authors: Kojima Ichiko , Uehara Kosuke , Iidaka Toshiko , Kodama Rie , Muraki Shigeyuki , Oka Hiroyuki , Kawaguchi Hiroshi , Akune Toru , Hashizume Hiroshi , Yamada Hiroshi , Yoshida Munehito , Morizaki Yutaka , Nakamura Kozo , Tanaka Sakae , Yoshimura Noriko 
Published: January 2025

ABSTRACT

Objectives
This study aimed to investigate the prevalence of radiographic hand osteoarthritis (HOA) in older Japanese individuals in three distinct regions with unique geographic and occupational characteristics and explore the regional variations and factors, including occupational workload, that affect HOA.

Methods
We analysed the radiographic images and data of 1642 participants aged ≥60 years (mean, 75.6 years). After grading the radiographs of both hands using the modified Kellgren–Lawrence (KL) classification, HOA was defined as at least one joint with a KL grade ≥2, and severe HOA was defined as at least one joint with a KL grade ≥3.

Results
The overall prevalence rates of HOA and severe HOA were 95.9% and 54.2%, respectively. Regional differences were observed: residence in the mountainous region was associated with HOA and severe HOA, whereas residence in the coastal region was associated with only HOA. Occupational workload was associated with severe HOA in a dose-dependent manner, and heavy work was associated with a higher number of osteoarthritis-affected joints.

Conclusion
The present study revealed a high prevalence of HOA in older Japanese individuals and highlighted regional variations in HOA prevalence. A higher occupational workload was associated with a higher risk of severe HOA.
Management of a Left Anterior Descending Artery Aneurysm in Behçet’s Disease: A Case Report
Authors: Subki Ahmed Hussein , Albeity Abdurahman , Mulla Israa Mohammed , Ismaeil Nabeel Hashim , Qarah Muhannad Basheer , Halabi Hussein 
Published: January 2025

Abstract
Behçet’s disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology that affects blood vessels of all sizes, potentially leading to severe complications such as coronary artery aneurysms. This report describes the case of a 33-year-old woman with BD who presented with recurrent chest pain. Imaging revealed a large saccular aneurysm in the left anterior descending artery. Management involved multiple percutaneous coronary interventions to stabilize the aneurysm, alongside infliximab, a tumor necrosis factor-alpha inhibitor, to control the underlying vasculitis. The patient has remained in clinical remission for over three years, providing additional evidence supporting the role of infliximab in addressing vascular complications in BD. This case highlights the challenges in managing coronary artery aneurysms in BD and emphasizes the need for further research into the long-term safety and efficacy of infliximab for such cases.
Evaluation of Daptomycin Use in Outpatients With Methicillin-Sensitive Staphylococcus aureus Bloodstream Infections
Authors: Kener Daisy , Childress Darrell , Andrus Ian , Olson Jared , Webb Brandon 
Published: January 2025

Abstract
Multiple observational studies in methicillin-resistant Staphylococcus aureus and enterococcal infections have suggested that higher doses of daptomycin may be associated with better clinical outcomes. However, optimal daptomycin dosing in methicillin-sensitive S aureus bloodstream infections remains unclear. In this multicentered, retrospective, observational cohort study, we compared standard dose daptomycin (&lt;8 mg/kg) vs high dose (≥8 mg/kg) for methicillin-sensitive S aureus bloodstream infections. In a propensity-weighted model, the composite outcome of treatment failure within 90 days was lower in the high-dose group relative to the standard dose group (odds ratio, 0.496; 95% CI, .306–.804). We did not detect any significant difference in safety outcomes.
The Promises and Perils of Periodization in Global History: Lessons from the Inter-War Era
Authors: Denning Andrew , Tworek Heidi J S 
Published: January 2025

Abstract
This article considers the role of periodization in global history through the lens of the inter-war era. The global turn has shifted the ‘metageographies’ of historical practice, focusing historians’ attention on the flows, mobilities and networks that connected peoples and places across the globe. Often left uninterrogated, however, are the ‘metatemporalities’ that structure historical inquiry, resulting in the perpetuation of Eurocentric definitions of historical epochs, particularly in the modern era. Periodizations are not objective or merely descriptive containers for historical events, but are themselves arguments that promote certain historical actors and dynamics from particular places, while relegating others to reactive roles, if not historiographical obscurity. The inter-war era offers a particularly compelling case study that shows how global history methodologies qualify, extend and dissolve inherited temporal frameworks. In place of singular, Eurocentric eras, polycentric global history presents the opportunity to elaborate polytemporal models that advance plural, overlapping periodizations. Aligning multiple global periodizations and becoming attuned to the rhythms they produced allows historians to reveal the particularity of historical eras.
The actin cytoskeleton regulates danger-associated molecular pattern signaling and PEP1 RECEPTOR1 internalization
Authors: Qian Hongping , Zuo Xinxiu , Man Yi , Xu Changwen , Luo Pengyun , Yao Lijuan , Geng Ruohan , Wang Binghe , Niu Shihui , Lin Jinxing , Cui Yaning 
Published: January 2025

Abstract
In plants, cytoskeletal proteins assemble into dynamic polymers that play numerous roles in diverse fundamental cellular processes, including endocytosis, vesicle trafficking, and the spatial distribution of organelles and protein complexes. Plant elicitor peptides (Peps) are damage/danger-associated molecular patterns (DAMPs) that are perceived by the receptor-like kinases PEP RECEPTOR 1 (PEPR1) and PEPR2 to enhance innate immunity and inhibit root growth in Arabidopsis (Arabidopsis thaliana). To date, however, there is little evidence that the actin cytoskeleton of the host cell participates in DAMP-induced innate immunity. Here, we demonstrated that the actin cytoskeleton alters the Pep1-triggered immune response. In addition, dual-color total internal reflection fluorescence–structured illumination microscopy (TIRF-SIM) showed that PEPR1 diffusion on the plasma membrane is closely related to the actin cytoskeleton. We performed single-particle tracking to quantify individual protein particles and found that the actin cytoskeleton notably regulates PEPR1 mobility and cluster size. More importantly, we demonstrated that actin filament reconfiguration is sufficient to inhibit Pep1-induced internalization, which alters the immune response. Taken together, these findings suggest that the actin cytoskeleton functions as an integration node for Pep1 signaling and PEPR1 endocytosis.
Measures to prevent esophageal stenosis are necessary after endoscopic submucosal dissection for early esophageal cancer lesions with a circumferential ratio of 75%–99%: a retrospective case analysis
Authors: Gao Yong , Zhu Jiao , Li Jianjun , Peng Xue , Nie Xubiao , Zhao Haiyan , Sheng Lifu , Fan Chaoqiang , Bai Jianying 
Published: January 2025

Abstract

Purpose
Endoscopic submucosal dissection (ESD) is currently one of the most curative treatments for early esophageal cancer. We conducted a retrospective case analysis to identify the characteristics of early esophageal cancer that indicate esophageal stenosis prevention measures. Our aim was to provide a reference for clinical decision-making.

Methods
Six hundred and fifty-four patients with early esophageal cancer treated with ESD were admitted to our hospital between January 2011 and December 2018.Clinical information such as patients’ demographic characteristics, lesion features, preventive measures if any, and complications of esophageal stenosis after ESD were collected from the hospital information system. The data were statistically analysed by SPSS software (version 23.0).

Results
1. Seventy-nine patients with early esophageal cancer suffered from esophageal stenosis after ESD. The median time from undergoing ESD to the first occurrence of stenosis was 27 (17–43) days. Specifically, among the 79 cases, 47 of them experienced stenosis within one month after ESD, and 23 cases experienced stenosis between 1 and 2 months after ESD, and 9 cases experienced stenosis more than 2 months after the operation.
2. Taking preventive measures significantly reduced overall esophageal stenosis incidence in patients with early esophageal cancer with lesion circumferential ratio of 75%–99% (P &lt; 0.05).
3. Among patients with early esophageal cancer with 75%–99% circumferential proportion of lesions, the risk of esophageal stenosis within 2 months without prevention measures was 2.617(95% CI, 1.057–6.479) times higher than that with prevention measures.

Conclusion
It is necessary to take measures to prevent esophageal stenosis after ESD for early esophageal cancer lesions with a circumferential ratio of 75%–99%.
Anti-citrullinated protein antibody detection by hemagglutination
Authors: Kruis Ilmar , Kumari Jyoti , van der Heijden Annemarie , Weijn Amrah , Vree Egberts Wilma , Peeters Iris Rose , van Herwaarden Noortje , Salden Martin , Pruijn Ger J M 
Published: January 2025

Abstract

Objectives
ACPAs play an important role in the classification of RA and can be detected by serological tests. Several ACPA detection assays are available for clinical use, which are all based on ELISA(-like) tests with citrullinated peptides (CCP2) or alternative citrullinated proteins/peptides. We aimed to facilitate ACPA detection in low-volume laboratories and resource-poor environments by developing a rapid and easy-to-perform test.

Methods
We designed and generated an agglutination mediator by protein engineering. A single-chain antibody fragment that binds to glycophorin A, one of the major surface proteins of erythrocytes, was conjugated to a CCP2-like peptide. This agglutination mediator was used to assess ACPA in RA and PsA patients and in healthy individuals.

Results
The agglutination mediator bound to erythrocytes was reactive with ACPA and induced haemagglutination in an ACPA-dependent fashion, which can be detected by the naked eye. The applicability was assessed by the analysis of fresh blood samples from 204 RA patients, 77 PsA patients and 100 healthy individuals. Agglutination was observed in up to 61% of the RA samples, which correlated well with the results obtained with a standardized anti-CCP2 ELISA (63–67%). Depending on the minimal agglutination score, agglutination was observed in only 3–21% of the PsA samples and in 1% of the healthy controls.

Conclusion
We conclude that the agglutination mediator allows rapid and efficient detection of ACPA by haemagglutination in human blood samples and offers a low-threshold method for ACPA detection.
Maintained growth performance and reduced mortality of genetically resistant nursery pigs after an experimental virulent F18 enterotoxigenic Escherichia coli challenge
Authors: Welch Michael W , Cross Amanda J , Solar Diaz Iara D P , Johnson Danielle C , Parr Eric , Rathje Tom A , Borg Randy C , Boler Dustin D 
Published: January 2025

Abstract
Enterotoxigenic Escherichia coli (ETEC) is a leading cause of postweaning diarrhea (PWD) and mortality of weaned pigs. The objective of this study was to evaluate genetic resistance of the polymorphism at nucleotide 307 (M307) in the FUT1 gene, to F18 E. coli infection considering different genotypes. A total of 179 pigs were used for this study. Pigs were genotyped for susceptibility to F18+ E. coli prior to the trial. Treatments included: genotype M307GA—heterozygous for E. coli susceptibility (A), genotype M307GG—homozygous E. coli susceptibility (B), or genotype M307AA—homozygous for E. coli resistance (C). Pigs were weighed, assigned to pens based on genotype, and allowed to acclimate for 3 d prior to the challenge. On days 4, 5, and 6, pigs were inoculated intraorally at the oropharynx with an F18+ E. coli isolate at a geometric mean concentration of 9.8 × 109. Growth rate (average daily gain [ADG]), feed intake (average daily feed intake), and gain-to-feed ratio (G:F) were calculated by pen. All pigs were humanely euthanized at the end of the trial. Two fixed sections of ileum and distal jejunum were collected from a subpopulation and tested by in situ hybridization (ISH) to evaluate F18+ E. coli adherence. Fresh ileum samples were used for enumeration of F18, total E. coli, and total bacteria by real-time polymerase chain reaction. Mortality rates during the trial were 26.7% for genotype A, 18.3% for genotype B, and 0.0% for genotype C (P &lt; 0.01). Starting weights prior to inoculation were not different (P = 0.29) among genotypes. Overall, pigs from genotype C grew 223 g/d faster (P = 0.04) than genotype A. Pigs from genotype C tended to grow 185 g/d faster (P = 0.09) than genotype B. G:F for genotype C (0.74) was 23% greater (P &lt; 0.01) than G:F for genotype A (0.60) and tended to be 12% greater (P = 0.07) than genotype B (0.66). There were no differences in ADG or G:F between genotypes A and B. F18-specifc Cq units were decreased by 7.74 and 6.47 in genotypes A and B compared with genotype C (P ≤ 0.03). Signal by ISH was increased by 14.0-fold in genotype A compared with genotype C (P = 0.02). Adherence was not different among genotypes (P = 0.40). Genotype A had greater mortality and poorer growth performance than genotype B or C. Genotype C had no mortalities during the trial, grew faster, was more feed efficient, and had less F18 E. coli in the ileal mucosa compared with genotype A. Resistant genotypes provide an opportunity to reduce PWD and mortality due to an F18+ E. coli infection.