bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging of Tendinous and Muscular Anatomical Variants Around the Ankle
Authors: Tomažin Tjaša , Plut Domen , Snoj Žiga 
Published: April 2023

AbstractTendinous and muscular anatomical variants around the ankle are usually an unexpected finding on imaging. Magnetic resonance imaging offers the best visualization of the accessory muscles; however, they can also be detected on radiography, ultrasonography, and computed tomography. Their accurate identification facilitates appropriate management of the rare symptomatic cases, mostly caused by accessory muscles in the posteromedial compartment. Symptomatic patients present with chronic ankle pain, most commonly as tarsal tunnel syndrome. The most frequently observed accessory muscle around the ankle is the peroneus tertius muscle, an accessory muscle in the anterior compartment. The tibiocalcaneus internus and peroneocalcaneus internus are uncommon; anterior fibulocalcaneus is rarely mentioned. We describe the anatomy of the accessory muscles with their anatomical relations accompanied by schematic drawings and radiologic images from clinical practice.
Ramadan Fasting and Diabetes (2022): The Year in Review
Authors: Hafidh Khadija , Besheya Tawfik A. , Elmehdawi Rafik , Beshyah Salem A. 
Published: April 2023

Abstract
Objectives The literature on the impact of Ramadan fasting (RF) on metabolic control and health in people with diabetes is widely spread in many journals making it not readily accessible to those interested in the subject. We aimed to provide a narrative overview of the global literature production in 1 year (2022) on diabetes and RF.
Materials and Methods It is a narrative, non-systematic review of the international literature from a single major medical online database (i.e., PubMed) in one calendar year (2022). Relevant literature was narrated in a concise thematic account.
Results Themes emerged from the review of the literature on RF published in 2022, including a couple of studies on the epidemiology of fasting in the real world by adults and children. Three studies involved some pathophysiological observations of metabolic and other biochemical markers. Several studies assessed the use and safety of different pharmacological therapeutic agents. Certain sulfonylureas, such as modified-release gliclazide, were considered safer than other sulfonylureas. Newer basal insulin analogs were studied in different geographical and socioeconomic settings (Gulf vs. South East Asia). The role of diabetes technology in Ramadan was the focus of several studies of insulin pumps and monitoring. Special themes were high-risk groups, pregnancy, acute complications, postbariatric surgery, and COVID-19 in Ramadan. Few studies examined the safety of sodium-glucose co-transporter-2 inhibitors as a class and individually during RF. Professional and patient perspectives released in 2022 included updated guidelines for adults and adolescents.
Conclusion In 2022's medical literature, RF and diabetes continue to address epidemiology, the burden of diabetes care on fasting patients, and discussions of concerns of patients and healthcare professionals. Risk stratification and issues of high-risk patients are still in focus for children, adolescents, and adults. Approaches to effective management still gather evidence for newer pharmacological agents and diabetes technology.
A resonant inertial impact rotary piezoelectric motor based on a self-clamping structure
Authors: He Liangguo , Wan Zhikai , Li Kun , Wang Yong , Li Xinyu , Ge Xinfang , Dou Haotian , Shan Zengxiang , Yue Xukang , Qian An 
Published: April 2023

A resonant inertial impact rotary piezoelectric motor based on a self-clamping structure is designed, assembled, and tested. The designed piezoelectric motor mainly includes a rotor (two vibrators, preload mechanism, and intermediate connection mechanism), a clamping mechanism, and another auxiliary mechanism. The piezoelectric ceramic sheet on the rotor drives the vibrator to swing under the excitation of a single harmonic wave. Because there is a clamping mechanism formed by the combination of clamp baffle and fixed clamp ring, thus the half-cycle resonant rotation of the rotor can be effectively completed, and repeated harmonic excitation can realize the unidirectional continuous rotation and swing of the rotor. The whole excitation process of the motor is in a resonance state, which has significant advantages, such as low friction and simple structure, compared with the traditional quasi-static piezoelectric motor. The structure of the piezoelectric motor is designed and analyzed using COMSOL5.5 software and then the motor performance is tested and analyzed by building an experimental platform to verify the feasibility of the motor design. The final experimental results show that the optimal working frequency of the piezoelectric motor is 150 Hz, which is consistent with the characteristic frequency of the simulation. When the motor prototype is under the conditions of optimal operating frequency 150 Hz, voltage 240 Vp-p, and preload torque 7.8 N.mm, the maximum angular speed can reach 2.4 rad/s, the maximum load can reach 27.8 N mm and the maximum resolution of the movement angle can reach 0.941°.
Ultrasound pulse generation through continuous-wave laser excited thermo-cavitation for all-optical ultrasound imaging
Authors: Liu Haojie , Wu Yuhan , Hou Chengtian , Chen Zitao , Shen Bingyan , Luo Zhiwei , Liang Hao , Ma Jun , Guan Bai-Ou 
Published: April 2023

The optical generation of pulsed ultrasound is attractive to nondestructive testing and biological imaging, especially for those involving narrow operation space or strong electro-magnetic interference. However, conventional techniques based on the photoacoustic effect inevitably required an expensive high-energy short pulsed laser and dedicated preparation of the optically absorptive composite film. Here, a fiber-optic ultrasound pulse transmitter based on continuous-wave (CW) laser triggered thermo-cavitation was demonstrated. The fiber-delivered CW laser light heated the highly-absorptive copper nitrate solution and generated explosive bubbles , which emitted strong ultrasound waves. Omnidirectional ultrasound pulses with an amplitude up to 0.3 MPa and a repetition rate of 5 kHz in the frequency range of 5–12 MHz were obtained by using a 50 mW optical heating power at a wavelength of 980 nm. The fiber-tip ultrasound transmitter was integrated with a polymer-cavity-based fiber ultrasound detector to construct an all-fiber ultrasound endoscopic imaging probe. Without the need for a wavelength-tunable laser, the ultrasound detector was interrogated by CW laser light with a fixed wavelength, coupled with feedback-controlled heating of the cavity to stabilize its spectral fringe. The CW laser-driven fiber ultrasound transmitter, in combination with the photothermally stabilized fiber ultrasound detector, opens new routes for a number of ultrasound-related industrial and biomedical applications.
The magnitude and pace of photosynthetic recovery after wildfire in California ecosystems
Authors: Hemes Kyle S. , Norlen Carl A. , Wang Jonathan A. , Goulden Michael L. , Field Christopher B. 
Published: April 2023

Wildfire modifies the short- and long-term exchange of carbon between terrestrial ecosystems and the atmosphere, with impacts on ecosystem services such as carbon uptake. Dry western US forests historically experienced low-intensity, frequent fires, with patches across the landscape occupying different points in the fire-recovery trajectory. Contemporary perturbations, such as recent severe fires in California, could shift the historic stand-age distribution and impact the legacy of carbon uptake on the landscape. Here, we combine flux measurements of gross primary production (GPP) and chronosequence analysis using satellite remote sensing to investigate how the last century of fires in California impacted the dynamics of ecosystem carbon uptake on the fire-affected landscape. A GPP recovery trajectory curve of more than five thousand fires in forest ecosystems since 1919 indicated that fire reduced GPP by

157.4

±

7.3

g C m

−
2

y

−
1

(

mean

±

SE,

n
=
1926

) in the first year after fire, with average recovery to prefire conditions after

∼
12

y. The largest fires in forested ecosystems reduced GPP by

393.8

±

15.7

g C m

−
2

y

−
1

(
n
= 401) and took more than two decades to recover. Recent increases in fire severity and recovery time have led to nearly

9.9

±

3.5

MMT CO

2

(3-y rolling mean) in cumulative forgone carbon uptake due to the legacy of fires on the landscape, complicating the challenge of maintaining California’s natural and working lands as a net carbon sink. Understanding these changes is paramount to weighing the costs and benefits associated with fuels management and ecosystem management for climate change mitigation.
Subclass-switched anti-spike IgG3 oligoclonal cocktails strongly enhance Fc-mediated opsonization
Authors: Izadi Arman , Hailu Arsema , Godzwon Magdalena , Wrighton Sebastian , Olofsson Berit , Schmidt Tobias , Söderlund-Strand Anna , Elder Elizabeth , Appelberg Sofia , Valsjö Maria , Larsson Olivia , Wendel-Hansen Vidar , Ohlin Mats , Bahnan Wael , Nordenfelt Pontus 
Published: April 2023

Antibodies play a central role in the immune defense against SARS-CoV-2. Emerging evidence has shown that nonneutralizing antibodies are important for immune defense through Fc-mediated effector functions. Antibody subclass is known to affect downstream Fc function. However, whether the antibody subclass plays a role in anti-SARS-CoV-2 immunity remains unclear. Here, we subclass-switched eight human IgG1 anti-spike monoclonal antibodies (mAbs) to the IgG3 subclass by exchanging their constant domains. The IgG3 mAbs exhibited altered avidities to the spike protein and more potent Fc-mediated phagocytosis and complement activation than their IgG1 counterparts. Moreover, combining mAbs into oligoclonal cocktails led to enhanced Fc- and complement receptor-mediated phagocytosis, superior to even the most potent single IgG3 mAb when compared at equivalent concentrations. Finally, in an in vivo model, we show that opsonic mAbs of both subclasses can be protective against a SARS-CoV-2 infection, despite the antibodies being nonneutralizing. Our results suggest that opsonic IgG3 oligoclonal cocktails are a promising idea to explore for therapy against SARS-CoV-2, its emerging variants, and potentially other viruses.
Research Progress on Solar Flare Forecast Methods Based on Data-driven Models
Authors: Han Ke , Yu Meng-Yao , Fu Jun-Feng , Ling Wen-Bin , Zheng De-quan , Wan Jie , E Peng 
Published: April 2023

Abstract
Eruption of solar flares is a complex nonlinear process, and the rays and high-energy particles generated by such an eruption are detrimental to the reliability of space-based or ground-based systems. So far, there are not reliable physical models to accurately account for the flare outburst mechanism, but a lot of data-driven models have been built to study a solar flare and forecast it. In the paper, the status of solar-flare forecasting is reviewed, with emphasis on the machine learning methods and data-processing techniques used in the models. At first, the essential forecast factors strongly relevant to solar flare outbursts, such as classification information of the sunspots and evolution pattern of the magnetic field, are reviewed and analyzed. Subsequently, methods of resampling for data preprocessing are introduced to solve the problems of class imbalance in the solar flare samples. Afterwards, typical model structures adopted for flare forecasting are reviewed from the aspects of the single and fusion models, and the forecast performances of the different models are analyzed. Finally, we herein summarize the current research on solar flare forecasting and outline its development trends.
Multi-objective optimization of process parameters of laser cladding 15-5PH alloy powder based on gray-fuzzy taguchi approach
Authors: Du Yanbin , He Guohua , Zhou Zhijie , Xu Lei , Huang Meina 
Published: April 2023

Abstract
Laser cladding is a new surface treatment technology that is widely used for surface modification of metal parts, and the high quality of the surface geometry of the cladding layer can save a lot of resources for the company. To obtain high quality of the clad layer, the L25 Taguchi experiment of laser cladding process parameters was designed to laser-clad a single 15-5PH layer on the surface of 45# steel; the effect of process parameters on the surface morphology and dilution rate of the coating was determined by ANOVA; the optimal combination of process parameters was obtained by combining gray correlation and fuzzy inference system method. The ANOVA results show that the scanning speed among the laser cladding process parameters plays a key role in obtaining the best superposition of the four geometrical features of the cladding layer simultaneously; With the optimization objectives of larger clad width and height, smaller clad depth, and 30% dilution rate, the optimal combination of process parameters, (P: 600W, V: 500 mm min−1, F

−1
: 1.3 r min−1), obtained based on the Gray-fuzzy Taguchi Approach, was compared and analyzed to find a significant improvement in the geometric quality characteristics of the optimized clad layer. The analysis of microstructure, physical phase, hardness, wear resistance and corrosion resistance showed that the 15-5PH clad layer was able to effectively enhance the surface properties of the 12Cr13 substrate. The optimization method proposed in this study can solve the problem of parameter optimization in the industrial multi-parameter and multi-response processes.
DNAscan2: a versatile, scalable, and user-friendly analysis pipeline for human next-generation sequencing data
Authors: Marriott Heather , Kabiljo Renata , Al Khleifat Ahmad , Dobson Richard J , Al-Chalabi Ammar , Iacoangeli Alfredo 
Published: April 2023

Abstract

Summary
The current widespread adoption of next-generation sequencing (NGS) in all branches of basic research and clinical genetics fields means that users with highly variable informatics skills, computing facilities and application purposes need to process, analyse, and interpret NGS data. In this landscape, versatility, scalability, and user-friendliness are key characteristics for an NGS analysis software. We developed DNAscan2, a highly flexible, end-to-end pipeline for the analysis of NGS data, which (i) can be used for the detection of multiple variant types, including SNVs, small indels, transposable elements, short tandem repeats, and other large structural variants; (ii) covers all standard steps of NGS analysis, from quality control of raw data and genome alignment to variant calling, annotation, and generation of reports for the interpretation and prioritization of results; (iii) is highly adaptable as it can be deployed and run via either a graphic user interface for non-bioinformaticians and a command line tool for personal computer usage; (iv) is scalable as it can be executed in parallel as a Snakemake workflow, and; (v) is computationally efficient by minimizing RAM and CPU time requirements.

Availability and implementation
DNAscan2 is implemented in Python3 and is available at https://github.com/KHP-Informatics/DNAscanv2.
PDC: a highly compact file format to store protein 3D coordinates
Authors: Zhang Chengxin , Pyle Anna Marie 
Published: April 2023

AbstractRecent improvements in computational and experimental techniques for obtaining protein structures have resulted in an explosion of 3D coordinate data. To cope with the ever-increasing sizes of structure databases, this work proposes the Protein Data Compression (PDC) format, which compresses coordinates and temperature factors of full-atomic and Cα-only protein structures. Without loss of precision, PDC results in 69% to 78% smaller file sizes than Protein Data Bank (PDB) and macromolecular Crystallographic Information File (mmCIF) files with standard GZIP compression. It uses ∼60% less space than existing compression algorithms specific to macromolecular structures. PDC optionally performs lossy compression with minimal sacrifice of precision, which allows reduction of file sizes by another 79%. Conversion between PDC, mmCIF and PDB formats is typically achieved within 0.02 s. The compactness and fast reading/writing speed of PDC make it valuable for storage and analysis of large quantity of tertiary structural data.Database URL https://github.com/kad-ecoli/pdc
Genetic and clinical factors underlying a self-reported family history of heart disease
Authors: Jowell Amanda R , Bhattacharya Romit , Marnell Christopher , Wong Megan , Haidermota Sara , Trinder Mark , Fahed Akl C , Peloso Gina M , Honigberg Michael C , Natarajan Pradeep 
Published: April 2023

Abstract

Aims
To estimate how much information conveyed by self-reported family history of heart disease (FHHD) is already explained by clinical and genetic risk factors.

Methods and results
Cross-sectional analysis of UK Biobank participants without pre-existing coronary artery disease using a multivariable model with self-reported FHHD as the outcome. Clinical (diabetes, hypertension, smoking, apolipoprotein B-to-apolipoprotein AI ratio, waist-to-hip ratio, high sensitivity C-reactive protein, lipoprotein(a), triglycerides) and genetic risk factors (polygenic risk score for coronary artery disease [PRSCAD], heterozygous familial hypercholesterolemia [HeFH]) were exposures. Models were adjusted for age, sex, and cholesterol-lowering medication use. Multiple logistic regression models were fitted to associate FHHD with risk factors, with continuous variables treated as quintiles. Population attributable risks (PAR) were subsequently calculated from the resultant odds ratios. Among 166 714 individuals, 72 052 (43.2%) participants reported an FHHD. In a multivariable model, genetic risk factors PRSCAD (OR 1.30, CI 1.27–1.33) and HeFH (OR 1.31, 1.11–1.54) were most strongly associated with FHHD. Clinical risk factors followed: hypertension (OR 1.18, CI 1.15–1.21), lipoprotein(a) (OR 1.17, CI 1.14–1.20), apolipoprotein B-to-apolipoprotein AI ratio (OR 1.13, 95% CI 1.10–1.16), and triglycerides (OR 1.07, CI 1.04–1.10). For the PAR analyses: 21.9% (CI 18.19–25.63) of the risk of reporting an FHHD is attributed to clinical factors, 22.2% (CI% 20.44–23.88) is attributed to genetic factors, and 36.0% (CI 33.31–38.68) is attributed to genetic and clinical factors combined.

Conclusions
A combined model of clinical and genetic risk factors explains only 36% of the likelihood of FHHD, implying additional value in the family history.
Beliefs as causal mediators in the design of communication interventions: exploring semantic and affective priming in parallel encouragement designs
Authors: Kim Jinha , Cappella Joseph N 
Published: April 2023

Abstract
The design of communication campaigns to alter health behaviors often begins with the identification of behavioral beliefs assumed to be causal antecedents of behavioral intentions. The assumption beliefs are causal derives from various theories of belief and intention/behavior and from statistical patterns of correlation. In cases of high-risk/cost campaigns, presuming causal order should require additional evidence. One approach is the parallel encouragement design which involves “randomly encouraging” levels of the mediator to establish its causal linkage to the outcome. This study proposes and tests a novel method of randomly encouraging beliefs as the mediator of messages on intention. Results show that semantic priming altered misbeliefs about Natural American Spirit cigarettes which in turn influenced intentions, suggesting its utility as an encouragement method to establish causal mediation of beliefs in message effects models. Results for countercampaign messages and broader theoretical and practical implications are discussed.
Lung adenocarcinoma cell-derived exosomes promote M2 macrophage polarization through transmission of miR-3153 to activate the JNK signaling pathway
Authors: Xu L , Wang L , Yang R , Li T , Zhu X 
Published: April 2023

Abstract
There is increasing evidence that exosome-mediated transmission of microRNAs helps to connect tumor-associated macrophages and cancer cells, including lung adenocarcinoma (LUAD) cells. The objective of this study is to identify the role of miR-3153 in LUAD progression and M2 macrophage polarization and explore its regulatory mechanism. The relevant molecular mechanisms were analyzed and validated through mechanistic assays. In vitro functional assays followed by in vivo experiments were implemented to evaluate the role of exosomes in mediating M2 macrophage polarization and LUAD progression. LUAD cells transmitted miR-3153 through exosomes. Heterogeneous nuclear ribonucleoprotein A2B1 promoted miR-3153 biosynthesis and exosomal sorting. Exosomal miR-3153 targeted zinc finger protein 91 to suppress the ubiquitination and degradation of misshapen-like kinase 1, thereby activating the c-Jun N-terminal kinase (JNK) signaling pathway and inducing M2 macrophage polarization. M2 macrophage polarization induced by LUAD cell-derived exosomes promoted the malignant process of LUAD cells. Transmission of exosomal miR-3153 by LUAD cells activates the JNK signaling pathway and induces M2 macrophage polarization, thus promoting the progression of LUAD.
Evaluation of carbon dioxide emission reduction in an energy cycle based on biomass gasification and molten carbonate fuel cell: exergoeconomic and environmental analyses
Authors: Zhang Di , Ma Te , Fooladi Hadi 
Published: April 2023

Abstract
A competitive advantage for the molten carbonate fuel cell (MCFC)-driven energy processes is their fuel versatility. On the other hand, since MCFC consumes carbon dioxide, it can reduce the amount of carbon dioxide emissions compared with other fuel cells. Accordingly, the current paper develops and evaluates the thermodynamic, exergoeconomic and environmental analyses of a new hybrid energy process (HEP) based on a reformer MCFC stack and a biomass gasification process. A homogeneous ignition engine (HIE) and a heat recovery system are two other main units embedded in the developed HEP. In the developed cycle, MCFC and HIE produce electric energy, for which the required fuel is supplied through the obtained syngas from the biomass gasification process and the anode off-gas, respectively. The heat recovery system also leads to the establishment of the thermal balance of the energy cycle by recovering the thermal energies of the MCFC and HIE. The aim of the present work is to develop the multi-aspect evaluation of the proposed energy system toward a fruitful implementation feasibility analysis. The outcomes indicated that the rates of electrical and thermal powers obtained from the planned HEP were equal to nearly 1112 and 367 kW, respectively. Further, the calculated efficiencies for electric, gross power and total energy terms were equal to 51.5%, 55.7% and 69.9%, respectively. The developed HEP had 48% less carbon dioxide emissions compared with a petroleum-fired power plant, 15.8% less compared with a natural gas-fired plant and approximately 63% lower compared with a coal-fired power plant.