bluuebunny/crossref_metadata_2025_split huggingface dataset:
Top management team stability and enterprise innovation: A chairman's implicit human capital perspective
Authors: Cao Danting , Yu Yike 
Published: January 2023

AbstractBased on the data of A‐share listed enterprise from 2008 to 2020, the paper investigates the impact of the stability of top management team on enterprise innovation from the perspective of chairman's implicit human capital. The results show that a stable top management team can effectively promote enterprise innovation; the chairman's psychological capital plays an inverted U‐shaped regulatory role in the impact of the stability of the top management team on enterprise innovation; the social capital and emotional capital play a positive regulatory role in the impact of the stability of the top management team on enterprise innovation. After further identifying the motivation of enterprise innovation, it is confirmed that the stability of top management team promotes enterprise innovation and the chairman's implicit human capital regulates enterprise substantive innovation. The research of this paper provides new ideas for optimizing the human resource and organizational structure of top management team and improve the efficiency of enterprise innovation.
Miniaturized nonresonant photoacoustic gas analyzer for CO2 detection
Authors: Zhang Guangyin , Guo Min , Zhao Xinyu , Cui Dongyu , Xu Lin , Wang Nan , Ni Rui , Qi Hongchao , Zhao Jikuan , Chen Ke 
Published: January 2023

AbstractIn this letter, a portable trace carbon dioxide (CO2) measurement instrument based on photoacoustic spectroscopy (PAS) was proposed and designed. The nonresonance PA cell (PAC) including a cooper tube with 251.2 μl was designed. Two condenser microphones were used to measure the PA signal simultaneously. The center wavelength of the distributed feedback laser was chosen to 2004 nm. Within 1 s integral time, the detection limit for CO2 reached 12.7 ppm. The normalized noise‐equivalent absorption coefficient was calculated to be 4.8468 × 10−9 cm−1W/Hz1/2. With Allan‐Werle deviation analysis, the measurement detection limit for CO2 improved to 4 ppm with 30 s integration time. As a result, the trace CO2 instrument based on PAS shows a good performance in long‐term detection.
A stochastic averaging gradient algorithm with multi‐step communication for distributed optimization
Authors: Zheng Zuqing , Yan Yu , Feng Liping , Du Zhenyuan , Li Huaqing , Wang Zheng , Hu Jinhui 
Published: January 2023

AbstractThis paper studies distributed convex optimization problems over an undirected network where all nodes cooperate to minimize a sum of local objective functions. Each local objective function is further assumed to be an average of several convex instantaneous functions. By incorporating the stochastic averaging gradient into the distributed first‐order primal‐dual method, a stochastic averaging gradient algorithm with multi‐step communication is proposed to solve the optimization problem. For each node, one randomly selected gradient of an instantaneous function is evaluated per iteration, which effectively reduces the computation cost of the algorithm. Based on conditions of strong convexity and Lipschitz continuity of the local instantaneous functions, a linear convergence rate of the proposed algorithm is guaranteed. Numerical simulations on the logistic regression problem demonstrate the performance of the algorithm and correctness of the theoretical results.
Aerosol Concentrations During Otolaryngology Procedures in a Negative Pressure Isolation Room
Authors: Seresirikachorn Kachorn , Sirinara Patthrarawalai , Tangjaturonrasme Napadon , Panyametheekul Sirima , Ngamsritrakul Thawat , Supaphan Uraiwan , Boonroung Thirayu , Ongphichetmetha Napassorn , Koosrivinij Saraporn , Snidvongs Kornkiat 
Published: January 2023

AbstractObjectiveTo evaluate the role of a negative pressure room with a high‐efficiency particulate air (HEPA) filtration system on reducing aerosol exposure in common otolaryngology procedures.Study DesignProspective quantification of aerosol generation.SettingsTertiary care.MethodsThe particle concentrations were measured at various times during tracheostomy tube changes with tracheostomy suctioning, nasal endoscopy with suctioning, and fiberoptic laryngoscopy (FOL), which included 5 times per procedure in a negative pressure isolation room with a HEPA filter and additional 5 times in a nonpressure‐controlled room without a HEPA filter. The particle concentrations were measured from the baseline, during the procedure, and continued until 30 minutes after the procedure ended. The particle concentrations were compared to the baseline concentrations.ResultsThe particle concentration significantly increased from the baseline during tracheostomy tube changes (mean difference [MD] 0.80 × 106 p/m3, p = .01), tracheostomy suctioning (MD 0.78 × 106 p/m3, p = .004), at 2 minutes (MD 1.29 × 106 p/m3, p = .01), and 3 minutes (MD 1.3 × 106 p/m3, p = .004) after suctioning. There were no significant differences in the mean particle concentrations among various time points during nasal endoscopy with suctioning and FOL neither in isolation nor nonpressure‐controlled rooms.ConclusionA negative pressure isolation room with a HEPA filter was revealed to be safe for medical personnel inside and outside the room. Tracheostomy tube change with tracheostomy suctioning required an isolation room because this procedure generated aerosol, while nasal endoscopy with suctioning and FOL did not. Aerosol generated in an isolation room was diminished to the baseline after 4 minutes.
Psychosocial Measures and Outcomes Among Caregivers of Children With Tracheostomies: A Systematic Review
Authors: Acorda Darlene E. , Brown Jennifer N. , Lambert Elton M. , Gibbs Karen DiValerio 
Published: January 2023

AbstractObjectiveChildren with tracheostomies have complex medical issues that require long‐term technology dependence and continuous medical care at home. Parents of tracheostomy‐dependent children often assume the majority of their child's home care leading to a shift in family dynamics and a decrease in caregiver quality of life. This systematic review sought to identify instruments to measure caregiver psychosocial outcomes after their child's tracheostomy and report on the findings.Data SourcesA systematic review was performed using Medline, CINAHL, and EMBASE.Review MethodsStudies that evaluated psychosocial outcomes in caregivers of tracheostomy‐dependent children were included.ResultsWe screened a total of 1286 nonduplicate records to include a total of 12 studies assessing the psychosocial outcomes of parents of tracheostomy‐dependent children. Fourteen instruments were identified. Caregivers reported lower quality of life when compared to other chronic caregiver groups. They experienced high degrees of stress, struggled to cope individually and as a family unit, and experienced decision regret and conflict.ConclusionFindings from this review suggest a significant impact on caregiver psychosocial well‐being, but few quantitative studies investigated this dynamic with measures validated in this caregiver population. This review demonstrates the need for longitudinal studies using validated tools to assess the long‐term impacts and outcomes of caregivers of the tracheostomy‐dependent child.
Anti‐CD40L therapy prevents the formation of precursor lesions to gastric B‐cell MALT lymphoma in a mouse model
Authors: Ying Le , Liu Phoebe , Ding Zhoujie , Wray‐McCann Georgie , Emery Jack , Colon Nina , Le Lena HM , Tran Le Son , Xu Ping , Yu Liang , Philpott Dana J , Tu Yugang , Cheah Daryl MZ , Cheng Chee L , Lim Soon T , Ong Choon K , Ferrero Richard L 
Published: January 2023

AbstractMucosa‐associated lymphoid tissue (MALT) lymphoma is a B‐cell tumour that develops over many decades in the stomachs of individuals with chronic Helicobacter pylori infection. We developed a new mouse model of human gastric MALT lymphoma in which mice with a myeloid‐specific deletion of the innate immune molecule, Nlrc5, develop precursor B‐cell lesions to MALT lymphoma at only 3 months post‐Helicobacter infection versus 9–24 months in existing models. The gastric B‐cell lesions in the Nlrc5 knockout mice had the histopathological features of the human disease, notably lymphoepithelial‐like lesions, centrocyte‐like cells, and were infiltrated by dendritic cells (DCs), macrophages, and T‐cells (CD4+, CD8+ and Foxp3+). Mouse and human gastric tissues contained immune cells expressing immune checkpoint receptor programmed death 1 (PD‐1) and its ligand PD‐L1, indicating an immunosuppressive tissue microenvironment. We next determined whether CD40L, overexpressed in a range of B‐cell malignancies, may be a potential drug target for the treatment of gastric MALT lymphoma. Importantly, we showed that the administration of anti‐CD40L antibody either coincident with or after establishment of Helicobacter infection prevented gastric B‐cell lesions in mice, when compared with the control antibody treatment. Mice administered the CD40L antibody also had significantly reduced numbers of gastric DCs, CD8+ and Foxp3+ T‐cells, as well as decreased gastric expression of B‐cell lymphoma genes. These findings validate the potential of CD40L as a therapeutic target in the treatment of human gastric B‐cell MALT lymphoma. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Addressing another threat to food safety: Conflict
Authors: Ortega‐Beltran Alejandro , Bandyopadhyay Ranajit 
Published: January 2023

Societal Impact StatementThe conflict between Ukraine and Russia will negatively affect not only food security but also food safety. Crops produced in Ukraine and Russia are at little risk of contamination by mycotoxins such as aflatoxin. However, due to the conflict, wheat, maize, sunflower, and other crops that would have been produced in and exported from Ukraine will need to be produced somewhere else. If done in warm production areas, strategies will need to be implemented to prevent mycotoxin contamination, which has negative health, social, and economic impacts.SummaryConflicts across the globe affect food security and also have a heavy toll on food safety. Many of the areas affected by conflict are breadbaskets for multiple countries. When the production of staple crops is compromised by diverse conflicts, it becomes necessary to grow them somewhere else to satisfy local, regional, and/or international requirements. However, if that production is done in tropical and subtropical zones, it must be done incorporating strategies to prevent mycotoxin contamination, which has negative health, social, and economic impacts. Otherwise, increased production of susceptible crops in mycotoxin‐prone areas may augment the already occurring negative impacts, which are severe in the global south.
Structural characterization, derivatization and antibacterial activity of secondary metabolites produced by termite‐associated Streptomyces showdoensisBYF17
Authors: Huang Zhongdi , Tang Wei , Jiang Taoshan , Xu Xiaoting , Kong Kun , Shi Shuping , Zhang Shuxiang , Cao Wei , Zhang Yinglao 
Published: January 2023

AbstractBACKGROUNDInsect‐associated Streptomyces is a valuable resource for development of compounds with antibacterial potential. However, relatively little is known of the secondary metabolites produced by termite‐associated Streptomyces.RESULTSHere, seven compounds including o‐acetaminophenol (1), phenazine‐1,6‐dicarboxylic acid (2), phenylacetic acid (3), phenazinolin D (4), izumiphenazine A (5), izumiphenazine B (6) and phenazinolin E (7) were obtained from the fermentation broth of a termite‐associated Streptomyces showdoensis BYF17, which was isolated from the body surfaces of Odontotermes formosanus. Two additional novel derivative compounds (6a and 6b) were synthesized via acetylation and methylation, respectively. The structures of these compounds were elucidated by spectroscopic analyses. The antibacterial bioassay showed that compound 6a displayed strong inhibitory effects against Pseudomonas syringae pv. actinidiae (Psa), with a zone of inhibition (ZOI) diameter of 20.6 mm, which was comparable to that of positive gentamicin sulfate with a ZOI value of 25.6 mm. Furthermore, the Day 5 curative activities of both compounds 6 and 6a against kiwifruit bacterial canker were 71.5%, which was higher than those of referred oxine‐copper (55.0%) and ethylicin (46.8%) at a concentration of 200 μg mL−1. In addition, the mechanism analysis based on scanning electron microscopic observation revealed that both compounds 6 and 6a destroyed the integrity of the Psa cell membrane.CONCLUSIONThe results of biological tests showed that these bioactive compounds exhibit potent antimicrobial activities, which have the potential to be developed into new antibacterial agents. © 2023 Society of Chemical Industry.
A woman's lifetime risk disparities in maternal mortality in Ethiopia
Authors: Borde Moges Tadesse 
Published: January 2023

AbstractBackgroundIn Ethiopia, a woman's lifetime risk (chance) of dying from maternal causes over a woman's reproductive lifespan continues to be a public health challenge. However, detailed evidence is scarce. This study aimed to assess woman's lifetime risk disparities in maternal mortality.MethodsNational data from the Ethiopian Demographic and Health Survey from 2000 to 2016 were used. To determine a woman's lifetime risk of dying, first, the maternal mortality ratio was calculated. Then, a woman's lifetime risk of dying was calculated. Four policy‐relevant socio‐economic factors were assessed: residence, education, regional states and economic status. To assess a woman's lifetime risk disparities in maternal mortality, the rate ratio (R) was used as per the World Health Organization's Health Equity Assessment Toolkit and software.ResultsFrom 61,610 respondents, 795 deaths were reported. A woman's lifetime risk of dying nearly halved from 4.6% in 2000 (1 in 22 women) to 1.9% in 2016 (1 in 52 women). In 2016, the highest woman's lifetime risk of dying was observed among rural women (1 in 111 women), in Oromiya regional state (1 in 71 women), women with secondary education (1 in 82 women) and women with middle income (1 in 77 women). The socioeconomic factors that drive a woman's lifetime risk disparities in maternal mortality include residence (1.3‐times higher among rural women), regional state (2‐times higher among women in Oromiya regional state), education (6‐times higher among women with lower educational status), and economic status (1.3‐times higher among the poorest women).ConclusionEthiopian women experienced a high lifetime risk of maternal mortality which varies across socioeconomic groups. Therefore, equity‐oriented maternal healthcare is recommended to reduce the effects of structural inequities, such as poverty, and the inequitable distribution of the socioeconomic factors of maternal health that sustain a woman's lifetime risk disparities in maternal mortality.
Grey wolf optimizer and hybrid PSO‐GWO for reliability optimization and redundancy allocation problem
Authors: Bhandari Ashok Singh , Kumar Akshay , Ram Mangey 
Published: January 2023

AbstractAnalysis and optimization of system reliability have very much importance for developing an optimal design for the system while using the available resources. Several studies are centered towards reliability optimization using metaheuristics. In this study, a recently developed metaheuristic optimization algorithm called hybrid PSO‐GWO (HPSGWO) to solve the reliability‐redundancy optimization problem has been proposed. The HPSGWO fuses the Particle Swarm Optimization's (PSO) exploitation ability with the grey wolf optimizer's (GWO) exploration ability. The comparison of results with prior best results of PSO and GWO for the four benchmarks of reliability redundancy allocation problem demonstrates the HPSGWO as a productive enhancement strategy since it got promising answers than other metaheuristic algorithms.
Spatiotemporal adaptive state feedback control of a linear parabolic partial differential equation
Authors: Wang Jun‐Wei , Wang Jun‐Min 
Published: January 2023

AbstractThis article deals with the issue of asymptotic stabilization for a linear parabolic partial differential equation (PDE) with an unknown space‐varying reaction coefficient and multiple local piecewise uniform control. Clearly, the unknown reaction coefficient belongs to a function space. Hence, the fundamental difficulty for such issue lies in the lack of a conceptually simple but effective parameter identification technique in a function space. By the Lyapunov technique combined with a variant of Poincaré‐Wirtinger inequality, an update law is derived for estimate of the unknown reaction coefficient in a function space. Then a spatiotemporal adaptive state feedback control law is constructed such that the estimate of the unknown coefficient is bounded and the closed‐loop PDE is asymptotically stable in the sense of spatial norm if a sufficient condition given in terms of space‐time varying linear matrix inequalities (LMIs) is fulfilled for the estimated coefficient and the control gains. Both analytical and numerical approaches are proposed to construct a feasible solution to the space‐time varying LMI problem. With the aid of the semigroup theory, the well‐posedness and regularity of the closed‐loop PDE is also analyzed. Moreover, two extensions of the proposed adaptive control scheme are discussed: the PDE in ‐D space and the PDE with unknown diffusion and reaction coefficients. Finally, numerical simulation results are presented to support the proposed spatiotemporal adaptive control design.
Polyethylene Glycol (PEG‐200): An Efficient, Green and Biocompatible Reaction Medium for the Metal‐Free Synthesis of Functionalized 1,4‐Benzothiazines.
Authors: Islam Aminul , Singha Rabindranath , Ghosh Pranab 
Published: January 2023

AbstractAn efficient, simple and biocompatible one‐pot two‐component PEG‐200 catalysed approach for the synthesis of bioactive and medicinally important 1, 4‐benzothiazine derivatives from 2‐aminobenzothiols and 1, 3‐dicarbonyl compound has been demonstrated. Polyethylene glycol (PEG‐200) has proved to be a new class of green and biocompatible reaction media for the metal free organic synthesis.
Synthesis, Characterization, Bioactivity Screening and Computational Studies of Diphenyl−malonohydrazides and Pyridines Derivatives
Authors: Barqi Mashael M. , Abdellah Islam M. , Eletmany Mohamed R. , Ali Nada M. , Elhenawy Ahmed A. , Abd El Latif Fawy M. 
Published: January 2023

AbstractA series of new hydrazide (3 a–j) and pyridine (11 a–j) derivatives were synthesized using a convergent synthetic methodology by condensation of malono‐di(2‐phenylhydrazide) with arylidene malononitrile or arylidene ethyl cyanoacetate derivatives. The synthesized compounds (3, 11 a–j) were characterized using via IR, 1H‐, 13C‐NMR, and MS spectroscopies as well as elemental analysis. The biological activity of these molecules has been evaluated in vitro against two gram‐positive bacteria (Staphylococcus aureus and Streptococcus pneumoniae) and one‐gram negative bacteria (Escherichia coli), as well as one fungus (Candida albicans). The results of the bioactive assay revealed that the synthesized pyridine (11 a–j) derivatives had greater antibacterial efficacy than the hydrazide (3 a–j) derivatives and were comparable to the reference drug Augmentin. Furthermore, docking studies against the Staphylococcus aureus dihydrofolate reductase (DHFR) protein revealed that pyridine derivatives (11 a–j) had higher binding interactions affinity (ΔG=−9.59∼−7.69 kcal/mol) than diphenyl−malonohydrazide derivatives (3 a–j), which achieved a binding affinity in the range of (ΔG=−9.65∼−6.77 kcal/mol), supporting the experimental results. Finally, DFT and TD‐DFT were used to gain a better understanding of the structure‐activity relationship and biological activity of the new synthesized hydrazide/pyridine derivatives.
Boron‐Catalyzed α‐Functionalizations of Carboxylic Acids
Authors: Shimizu Yohei , Kanai Motomu 
Published: January 2023

AbstractCatalytic, chemoselective, and asymmetric α‐functionalizations of carboxylic acids promise up‐grading simple feedstock materials to value‐added functional molecules, as well as late‐stage structural diversifications of multifunctional molecules, such as drugs and their leads. In this personal account, we describe boron‐catalyzed α‐functionalizations of carboxylic acids developed in our group (five reaction types). The reversible boron carboxylate formation is key to the acidification of the α‐protons and enolization using mild organic bases, allowing for chemoselective and asymmetric bond formations of carboxylic acids. The ligand effects on reactivity and stereoselectivity, substrate scopes, and mechanistic insights are summarized.
Examining nanoparticles with different laser wavelengths in liquid environment
Authors: Senthilkumar Gnanamani , Vijayan Manikandan Lakshmana , Lokesh Thangavel 
Published: January 2023

AbstractThe focus of this present investigation is to examine the heating characteristics of gold and silver nanoparticles at different laser wavelengths. Comparative research on the heat transfer studies with gold ultrafine particles and silver ultrafine particles was undertaken to determine an appropriate frequency and substance with greater photothermic effectiveness for hyperthermic use in cancer therapy. At 488 nm and 540 nm, gold nanoparticles are found to be greater photothermally efficient than silver nanoparticles. The 540 nm laser burns gold nanoparticles greater than the 488 nm laser. Silver nanoparticles, on the other hand, showed a slightly lower temperature increase at 540 nm than at 488 nm. In the diametral surface range of 0–50 nm, size‐dependent impact research showed that the absorbance effectiveness of single gold nanoparticulate with larger diameters is larger than those with lower diameters.
Short‐term evaluation of renal markers in overweight adult cats
Authors: Pérez‐López Laura , Boronat Mauro , Melián Carlos , Santana Angelo , Brito‐Casillas Yeray , Wägner Ana M. 
Published: January 2023

AbstractBackgroundObesity has been proposed as an independently risk factor for chronic kidney disease (CKD) in people, but its role in feline kidney function is unknown.ObjectiveObesity has been proposed as an independent risk factor for chronic kidney disease (CKD) in people, but its role in feline kidney function is unknown. This study prospectively evaluated the effect of overweight on the concentration of symmetric dimethylarginine (SDMA) and creatinine in a cohort of healthy cats.MethodsForty healthy adult cats were included, 14 with a body condition score (BCS) = 5 and 26 with a BCS > 5. Cats were examined every 6 months, for up to 12 months. SDMA and creatinine were measured at baseline and follow‐up.ResultsNo effect was found for time of follow‐up (p = 0.072), overweight (p = 0.9442) or their interaction (p = 0.902) on SDMA, though a significant effect was found for age (p < 0.001) [older cats showing higher SDMA] and sex (p = 0.007) [male cats showing higher SDMA]. Regarding creatinine, no effect for time (p = 0.671), age (p = 0.061), overweight (p = 0.319) or the latter's interaction (p = 0.386) were found.ConclusionsIn the short term, markers of renal function did not show an association with overweight. The role of obesity in feline kidney function still warrants further evaluation.