bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful treatment of severe MSUD in Bckdhb−/− mice with neonatal AAV gene therapy
Authors: Pontoizeau Clément , Gaborit Clovis , Tual Nolan , Simon‐Sola Marcelo , Rotaru Irina , Benoist Marion , Colella Pasqualina , Lamazière Antonin , Brassier Anaïs , Arnoux Jean‐Baptiste , Rötig Agnès , Ottolenghi Chris , de Lonlay Pascale , Mingozzi Federico , Cavazzana Marina , Schiff Manuel 
Published: March 2023

AbstractMaple syrup urine disease (MSUD) is rare autosomal recessive metabolic disorder caused by the dysfunction of the mitochondrial branched‐chain 2‐ketoacid dehydrogenase (BCKD) enzyme complex leading to massive accumulation of branched‐chain amino acids and 2‐keto acids. MSUD management, based on a life‐long strict protein restriction with nontoxic amino acids oral supplementation represents an unmet need as it is associated with a poor quality of life, and does not fully protect from acute life‐threatening decompensations or long‐term neuropsychiatric complications. Orthotopic liver transplantation is a beneficial therapeutic option, which shows that restoration of only a fraction of whole‐body BCKD enzyme activity is therapeutic. MSUD is thus an ideal target for gene therapy. We and others have tested AAV gene therapy in mice for two of the three genes involved in MSUD, BCKDHA and DBT. In this study, we developed a similar approach for the third MSUD gene, BCKDHB. We performed the first characterization of a Bckdhb−/− mouse model, which recapitulates the severe human phenotype of MSUD with early‐neonatal symptoms leading to death during the first week of life with massive accumulation of MSUD biomarkers. Based on our previous experience in Bckdha−/− mice, we designed a transgene carrying the human BCKDHB gene under the control of a ubiquitous EF1α promoter, encapsidated in an AAV8 capsid. Injection in neonatal Bckdhb−/− mice at 1014 vg/kg achieved long‐term rescue of the severe MSUD phenotype of Bckdhb−/− mice. These data further validate the efficacy of gene therapy for MSUD opening perspectives towards clinical translation.
The upsides and downsides of thought experiments in I‐O/OB
Authors: Latham Gary P. 
Published: March 2023

SummaryConducting thought experiments prior to conducting a pilot study followed by a field experiment or correlational study have proven invaluable to the author for selecting an issue worthy of study, generating testable hypotheses, ways of manipulating the independent variable, selecting/developing a reliable dependent variable, thinking through a doable procedure, and coming up with ways to persuade senior managers to approve the proposed studies/experiments. Nevertheless, arguments are presented as to why thought experiments are at best the beginning rather than the endpoint in the research process.
Ultrahighly Efficient Narrowband Red Luminescence of Uniquely Distorted Mn4+ Octahedron in the Feldspar‐Type LED Phosphor
Authors: Liu Yiyang , Zhang Rong , Yan Kaiyi , Sun Jian‐Feng 
Published: March 2023

AbstractThe mineral structure‐inspired discovery of red phosphors has become a research hotspot that can help compensate for the missing red components in cold white light‐emitting diodes (WLEDs). Herein, first the feldspar‐type structure is utilized to develop narrowband red‐emitting CaAl2Si2O8:Mn4+/Mn4+, Mg2+ phosphors. Rietveld refinement results confirm the Mn4+ occupation of the distorted [Ca1O6] octahedron, resulting in a strong nephelauxetic effect, and thus exhibits bright red luminescence with a narrow full width at half maximum (43 nm). Compared with CaAl2Si2O8:Mn4+, the fluorescence intensity of CaAl2Si2O8:Mn4+, Mg2+ is further enhanced by up to 210% owing to the decreasing nonradiative decay rate from 2Eg excited state, which weakens the concentration quenching effect resulting from energy migration along the adjacently aggregated Mn4+. CaAl2Si2O8:Mn4+, Mg2+ shows preferable thermal stability with an ultrahigh quantum efficiency (90.3%), surpassing other current Mn4+‐doped oxide phosphors and UCr4C4‐type nitride phosphors. A fabricated prototype WLED obtains ideal warm white light with a low correlated color temperature (3081 K) and a wide color gamut covering 112% of the National Television System Committee standard. Guided by natural mineral‐type structural prototypes, this study demonstrates the possibility of designing a uniquely distorted local structure to achieve a superior luminescence performance of Mn4+ for warm WLEDs.
Aggregate and disaggregate performance measurements: Inter‐temporally correlated performance measures with limited commitment
Authors: Yoo Junwook 
Published: March 2023

AbstractThis study employs the LEN model in analyzing aggregations and disaggregate use of inter‐temporally correlated performance measures in two‐period agencies with limited commitment. The optimal disaggregate use where an agent's incentive is on basic measures suffers information loss to depend on agency particulars. Induced action is restricted by the subsequent period action, and limited commitment leads to fostering late optimal effort inducement. Performance measure aggregation yields inaccurate inter‐temporal information relative to the disaggregate use and leads to raising early optimal effort inducement. Both the total informativeness and the difference in informativeness of performance measures fortify early optimal effort inducement.
Two extended formulations for the virtual network function placement and routing problem
Authors: Mouaci Ahlam , Gourdin Éric , Ljubić Ivana , Perrot Nancy 
Published: March 2023

AbstractGiven a bi‐directed graph modeling a telecommunication network, and a set of origin‐destination pairs representing traffic requests (commodities) along with their associated Service Function Chains (SFCs), the Virtual Network Function Placement and Routing Problem (VNFPRP) aims to find, for each commodity, one latency‐constrained routing path that visits the required Virtual Network Functions in a specific order. The function installation costs together with the node activation costs have to be minimized. In this paper, we present two extended Mixed Integer Programming (MIP) formulations to model the VNFPRP. For each formulation we define the master problem, the pricing problem, the associated Lagrangian bound and a specific branching scheme, in order to derive an efficient Branch‐and‐Price algorithm. We also provide several families of valid inequalities to strengthen the LP‐relaxation bounds. Computational results are reported comparing the performance of the two Branch‐and‐Price algorithms with a compact MIP formulation and its Branch‐and‐Benders‐cut implementation on a set of SNDlib instances representing telecommunication networks.
An explicit phase field material point method for modeling dynamic fracture problems
Authors: Zeng Zhixin , Ni Ruichen , Zhang Xiong , Liu Yan 
Published: March 2023

AbstractA novel explicit phase field material point method (ex‐PFMPM) is proposed for modeling dynamic fracture problems. The rate‐dependent phase field governing equation is discretized by a set of particles, and the phase field is updated by the explicit forward‐difference time integration. Furthermore, the stability of the ex‐PFMPM is studied. A novel explicit critical time step formula is obtained based on the system eigenvalues in one dimension and then extended to two and three dimensions. The critical time step formula takes the effect of particle position and neighboring cell interaction into consideration, and can also be used in an explicit phase field finite element method. Several numerical examples, including a dynamic crack branching, a plate with pre‐existing crack under velocity boundary conditions and a three point bending problem are studied to verify the proposed ex‐PFMPM. The use of the history field in the explicit method is studied, which shows that it will lead to fake phase field update and overestimation of the fracture energy in the unloading case. All of the numerical results show that the proposed ex‐PFMPM has the capacity of modeling the crack initiation and propagation problems with both accuracy and efficiency.
An improved correlation stack method for near‐surface seismic data
Authors: Lu Xinglin , Wang Wei , Hu Xuquan , Liao Xian , Fu Zhixiong , Luo Chaopeng , Xu Zheng , Fu Zhihong 
Published: March 2023

AbstractThe seismic reflection method is the primary tool to provide detailed information on the near‐surface. This paper proposes a common receiver correlation stack method. A towed seismograph is used to perform the rapid acquisition with small geophone spacing and a high sample rate, while broadband (from 1 Hz to 1000 Hz) seismic data are collected. Results of modelled and measured data indicate that the proposed stack method: (1) does not need normal move‐out velocity; (2) does not lose shallow information; and (3) improves the stacking fold by twice as much as the conventional stack method. Compared with the conventional stack method, the proposed method can suppress surface waves better and improve the quality of the final sack section, especially for high‐frequency data. Combined with the towed seismograph, the proposed stack method can perform the rapid collection and enhance the accuracy of stack imaging of near‐surface seismic data.
Government assistance and family charitable giving: Comparing urban and rural residents in China
Authors: Wang Lili , Li Peiyao 
Published: March 2023

AbstractUsing data from the 2016 China Family Panel Studies, this paper examines the relationship between government assistance, urban/rural residency, and charitable giving. The results indicate that urban/rural residency moderates the relationship between government assistance and charitable giving in China. Urban residents who do not receive government assistance are much more likely to donate to charity than their rural counterparts. While urban residents with government assistance also show a higher likelihood of giving than government assistance recipients in the rural area, the difference is much smaller than that between the urban and rural non‐recipients. More interestingly, the results show that although urban residents without government assistance donate more to charity, those who receive a high amount of government assistance on average donate less to charity than their rural counterparts.
Chemometric study for the performances of deep eutectic solvents during the recovery of high‐added‐value substances from Moringa oleifera leaves: Principal component analysis
Authors: Kurtulbaş Ebru 
Published: March 2023

AbstractIntroductionMoringa oleifera is a plant with high antioxidant content in its leaves, flowers and seeds. It attracts the attention of researchers with the effect of its nutritional and medical advantages.ObjectiveThe purpose of the current study is to propose a deep eutectic solvent (DES)‐based ultrasound‐assisted extraction of bioactive substances from M. oleifera leaves by the application of a chemometric study.MethodologyA total of 18 different choline chloride‐based DESs were prepared by using several hydrogen bond donors (glucose, sucrose, glycerol, ethylene glycol, urea and dimethyl urea) with various molar ratios (1:1, 1:2 and 2:1) by addition of diluents (water and 50% methanol) or alone. In order to decide the best DES combination, principal component analysis (PCA) was applied. The response surface method (RSM) was used as statistical experimental design approach through the Box–Behnken design.ResultsThe best phenolic (TPC), flavonoid (TFC) and antioxidant activity yields of M. oleifera leaf extract were found to be 19.102 mg‐GAE, 10.47 mg‐CE and 24.404 mg‐TEAC per gram dried leaf under the optimal conditions (50% water content, 20% amplitude, 15 min time). The model fitting has been also found reliable depending on the statistical indicators such as p‐value (<0.0001), coefficients of determination (R2 = 0.9827, 0.9916 and 0.9864) and root mean square error (RMSE = 1.0562, 2.4656 and 0.7713).ConclusionsA chemometric study through PCA was carried out to determine the similarities and differences between the solvent groups, and the ethylene glycol‐based DES (1:2, molar ratio) with the addition of water showed the best performance.
Delivering comprehensive school‐based dialectical behavior therapy (CSB‐DBT)
Authors: Miller Alec L. , Gerardi Nora , Mazza James J. , Dexter‐Mazza Elizabeth , Graling Kelly , Rathus Jill H. 
Published: March 2023

AbstractThis manuscript provides a detailed examination of comprehensive school‐based dialectical behavior therapy (CSB‐DBT) as a critical component to the DBT services continuum provided in schools. Because suicide is the second leading cause of death among adolescents along with increased prevalence of self‐harming behavior, schools often find themselves thrust into the role of mental health providers especially around the issues of emotion regulation. Yet school personnel are often not formally trained to provide adequate services to these at‐risk students. This gap is filled by the implementation of CSB‐DBT. DBT is an evidence‐based, transdiagnostic treatment that has been adapted by Miller and Rathus for adolescents with a range of mental health difficulties characterized by emotional and behavioral dysregulation. Comprehensive DBT adapted for implementation in school‐based settings consists of four modes: Individual counseling, group skills training, in‐school coaching, and DBT provider consultation team. A fifth mode, caregiver involvement is encouraged, to the extent possible. Each mode will be explained in further detail along with the adaptation rationale that makes it distinct for school‐based application. Finally, discussion of implementation strategies, barriers, and support will be examined as important components for successfully integrating CSB‐ DBT.
Rezum water vapor therapy for patients with mild, moderate, or severe lower urinary tract symptoms: A retrospective study in a multiethnic population
Authors: Babar Mustufa , Loloi Justin , Tang Kevin , Singh Sandeep , Ines Matthew , Patel Rutul D. , Iqbal Nazifa , Ciatto Michael 
Published: March 2023

AbstractBackgroundThe Rezum System (Rezum) represents a novel, minimally invasive surgical therapy used to treat lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). We evaluated the safety and efficacy of Rezum in patients with mild, moderate, or severe LUTS.MethodsA single office, retrospective study was conducted on patients from a multiethnic population treated with Rezum between 2017 and 2019. Patients were categorized into three cohorts based on baseline International Prostate Symptom Score (IPSS) LUTS severity: mild LUTS (IPSS ≤ 7), moderate LUTS (IPSS 8–19), or severe LUTS (IPSS ≥ 20) cohorts. Outcome measures, including IPSS, quality of life (QoL), maximum urinary flow rate (Qmax), postvoid residual (PVR), BPH medication usage, and adverse events (AEs) were collected and analyzed at baseline, 1‐, 3‐, 6‐, and/or 12‐months postoperatively.ResultsA total of 238 patients were included: 33 with mild LUTS, 109 with moderate LUTS, and 96 with severe LUTS. At 1‐month follow‐up, the moderate and severe LUTS cohorts saw significant improvements in IPSS (moderate LUTS: −3.0 [−6.0, 1.5], p < 0.001; severe LUTS: −10.0 [−16.0, −5.0], p < 0.001) and QoL (moderate LUTS: −1.0 [−3.0, 0.0], p < 0.001; severe LUTS: −1.0 [−3.0, 0.0], p < 0.001) and improvements remained durable up to 12‐months (p < 0.001). The mild LUTS cohort saw significant worsening in IPSS by 2.0 (0.0, 12.0) at 1‐month (p = 0.002) but returned to baseline at 3‐months (p = 0.114). However, the mild LUTS cohort experienced significant improvements in QoL by −0.5 (−3.0, 0.0) at 3‐months (p = 0.035) and nocturia by 0.0 (−1.0, 0.0) at 6‐months (p = 0.002), both of which remained durable to 12‐months (p < 0.05). Most AEs were transient and nonserious, with gross hematuria (66.5%) being most common. There were no significant differences in QoL point reduction, Qmax improvement, PVR reduction, and AE occurrence between the cohorts at 12‐months (p > 0.05). At 12‐months, 80.0%, 87.5%, and 66.0% of the patients in the mild, moderate, and severe LUTS cohorts discontinued their BPH medications, respectively.ConclusionsRezum provides rapid and durable relief in LUTS in patients with moderate or severe LUTS and can be offered to patients with mild LUTS who have bothersome nocturia and wish to discontinue their BPH medications.
®Optimization of the Hydrolysis Reaction Process in the Synthesis of 4‐Aminoantipyrine by Response Surface Methodology and its Kinetics
Authors: Zhang Fuyue , Zhou Haoyu , Yuan Jinqiu , Li Qinghui , Diao Yanwei , Sun Xiaoyan , Zhang Liangjie , Lin Yuhang , Du Lei 
Published: March 2023

AbstractIn this paper, a unique hydrolysis reaction process for the production of 4‐Aminoantipyrine (AA) is investigated. A liquid‐phase analytical method for AA is established, and the amount of sulfuric acid, reaction temperature, reaction time are studied. On the basis of single factor experiments, the response surface method (RSM) is used to systematically optimize the conditions of the hydrolysis reaction. The optimum conditions are n(AT‐SO4): n(H2SO4)=0.73, the reaction temperature is 98 °C, the reaction time is 91 min, and the AA yield reaches 90.80 %. Compared with the previous process, the yield of AA is improved and colloids are significantly reduced. Under optimum process conditions, a kinetic model is constructed in the range of 358 K–373 K, which activation energy, Ea=33.21 kJ/mol, and the pre‐exponential factor, A=1586.84. In addition, the product AA is characterized by IR analysis, LC‐MS analysis, GC‐MS analysis and hydrolysis reaction mechanism are investigated.
Heterogeneous enzymatic catalysts: Comparing their efficiency in the production of biodiesel from alternative oils**
Authors: Ferrero Gabriel Orlando , Sánchez Faba Edgar Maximiliano , Vaschetto Eliana Gabriela , Eimer Griselda Alejandra 
Published: March 2023

AbstractIn this study, four heterogeneous enzymatic catalysts were synthesized: three from the immobilization of Pseudomonas fluorescens lipase (LPf) on SBA‐15, Ca/SBA‐15, and Na/SBA‐15, and one by the one‐step coprecipitation technique, named LOBE (Low Ordered Biosilicificated Enzyme). The physicochemical properties of these materials were determined by small‐angle X‐ray scattering (SAXS), Fourier‐Transform infrared spectroscopy (FT‐IR), inductively coupled plasma atomic emission spectroscopy (ICP), and N2 adsorption/desorption measurements. The biocatalysts activity was evaluated in the production of biodiesel with different oily raw materials. From these results, it was possible to infer that confinement effects influence catalytic efficiency. While the SBA‐15 material presents one‐dimensional channels, the LOBE biocatalyst has interconnected three‐dimensional cavities type MCM‐48 that favor the mixing of reactant phases (oil‐alcohol), the interaction with active sites in the structure, and mass transfer. Thus, this 3D architecture would increase the specific activity of the LOBE biocatalyst approximately five times concerning the other studied biocatalysts.
Synthesis, Spectral and Electrochemical Properties, and Computational Modeling of N‐Cymantrenylmethylphthalimide
Authors: Kelbysheva Elena S. , Strelkova Tatyana V. , Ezernitskaya Mariam G. , Alekseev Vladimir G. , Telegina Lyudmila N. 
Published: March 2023

AbstractPhoto‐ and electrochemical properties of a novel cymantrenyl‐containing (CpMn(CO)3) phthalimide were studied by cyclic voltammetry, FTIR, 1H NMR, UV‐vis, fluorescence spectral methods. It was found that upon irradiation of the initial tricarbonyl complex, one CO ligand is released to form a colored dicarbonyl chelate, which in the presence of CO enters the reverse thermal reaction to give the initial tricarbonyl complex. In the presence of some other external ligands, the chelate cycle is disclosed and dicarbonyl complex with external ligand is formed demonstrating hemilabile properties of the chelate studied. It was found that the introduction of a cymantrenyl group in a phthalimide molecule, which usually exhibits electron acceptor properties, has a significant effect on the characteristics of the absorption and emission spectra, electrochemical properties. This type compounds can be a basis for the creation of photo‐ and electroactive materials and exciplex‐forming materials
Role of Dual Nature of Ionic Liquid in Solvation Dynamics and Rotational Diffusion in Mixed Micelles: A Time‐Resolved Fluorescence and Fluorescence Anisotropy Study
Authors: Aggrawal Rishika , Halder Sayantan , Dyagala Shalini , Saha Subit Kumar 
Published: March 2023

AbstractThe present work demonstrates the role of the dual nature of an ionic liquid, 1‐dodecyl‐3‐methylimidazolium bromide (C12mimBr), in the solvation dynamics and rotational diffusion of Coumarin 153 (C‐153) in the aqueous mixed micellar solutions of three cationic gemini surfactants, 12‐s‐12,2Br− (where s = 4, 6 and 8) using different spectroscopic and light scattering techniques. Ionic liquid within the micelles controls the weightages of solvation components. In pure micelles of a gemini surfactant, the fast and slow solvation components are major and minor, respectively, which vary based on the concentration of the ionic liquid. The effective solvation rate enhances with increasing concentration of C12mimBr. Dual nature of C12mimBr governs the size of mixed micelles. Thus the associated time constant for rotational motion also alters accordingly. In micelle, lateral diffusion coefficient (DL) value enhances with its increasing size due to mixed micelle's increased porosity. Gemini spacer chain length effect is also discussed.
Multi‐responsive Luminescent Probe with Bis‐imidazolyl Biphenyl and Aromatic Polycarboxylic Acids Ligands for Sensing Fe3+, Cr2O72− and CrO42− in Aqueous Solution
Authors: Wang Yan , Gao Ningning , Hu Jiaqi 
Published: March 2023

AbstractOne zinc‐based metal organic framework (MOF): [Zn(LBIX)(HEA)]n (1) was synthesized by hydrothermal synthesis with 4,4′‐bis((1H‐imidazol‐1‐yl)methyl)‐1,1′‐biphenyl (LBIX) and 1,2‐phenylenediacetic acid (H2HEA) as ligands. The structure was characterized by single‐crystal X‐ray diffraction analysis, elemental analysis, infrared spectroscopy and thermogravimetric analysis. The single crystal structure analysis shows that the complex extends along three directions of a, b and c, forming a three‐dimensional structure. Experiments related to fluorescence show that the complex 1 has good fluorescence performance in aqueous solution and can be utilized to quickly identify Fe3+, CrO42− and Cr2O72− ions (Ksv quenching efficiency for Fe3+:1.71×104 M−1, CrO42−:1.07×104 M−1 and Cr2O72−:1.15×104 M−1) and low detection limits (Fe3+:1.52 μM, CrO42−:1.53 μM and Cr2O72−:1.70 μM).
Emissive‐Dye/Cucurbit[n]uril‐Based Fluorescence Probes for Sensing Applications
Authors: Chatterjee Sobhan , Liang Feng 
Published: March 2023

AbstractSupramolecular host‐guest chemistry has provided many opportunities for the design and construction of new fluorescent systems in various applications, particularly in the field of sensing. Owing to the special structure and fascinating utilities, cucurbit[n]urils (CB[n]s) existing themselves as a young family of molecular vessels, it construction a stable host‐guest supramolecular complex with a variety of fluorescent dyes and indicators, that has been used as a powerful fluorescent probe and is widely used in sensing and related research fields. Therefore, in this review article, we will outline and attention on the recent advances in the progress of various CB[n] ⋅ guest‐based fluorescent probes, it can provide a general overview of the construction, detection mechanism and fluorescence sensing of certain metal ions, biomolecules and toxic chemicals. Examples of the selection of other types of CB[n]‐based supramolecular assemblies and coordination polymers will also be covered. Finally, we will also provide important views on fluorescent CB[n] ⋅ guest‐based inclusion complex for metal ion and biomolecular sensors.