bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rural age‐friendly ecosystems for older adults: An international scoping review with recommendations to support age‐friendly communities
Authors: Liebzeit Daniel , Krupp Anna , Bunch Jacinda , Tonelli Shalome , Griffin Emily , McVeigh Sarah , Chi Nai‐Ching , Jaboob Saida , Nakad Lynn , Arbaje Alicia I. , Buck Harleah 
Published: May 2023

AbstractBackground and AimsThe population of older adults in rural areas is rising, and they experience higher rates of poverty and chronic illness, have poorer health behaviors, and experience different challenges than those in urban areas. This scoping review seeks to (1) map the state of the science of age‐friendly systems in rural areas regarding structural characteristics, processes for delivering age‐friendly practices, and outcomes of age‐friendly systems, (2) analyze strengths, weakness, opportunities, and threats of age‐friendly system implementation, and (3) make person, practice, and policy‐level recommendations to support active aging and development of age‐friendly communities.MethodsAn international scoping review was conducted of articles that used age‐friendly framing, had a sample age of 45 years of age or older, self‐identified as rural, and reported empiric data. Searches were conducted in PubMed, CINAHL, AgeLine, PsychINFO, EMBASE, Scopus, and Academic Search Elite on October 26, 2021, and rerun March 10, 2023. Data were charted across three analytic layers: socioecological model, Donabedian's framework, and SWOT analysis.ResultsResults reveal limited data on outcomes relevant to organizations, such as return on investment or healthcare utilization. While the SWOT analysis revealed many strengths of age‐friendly systems, including their impact on persons' outcomes, it also revealed several weaknesses, threats, and gaps. Namely, age‐friendly systems have weaknesses due to reliance on trained volunteers and staff, communication, and teamwork. System‐level threats include community and health system barriers, and challenges in poor/developing areas.ConclusionsWhile age‐friendly systems in this review were heterogeneous, there is an opportunity to focus on unifying elements including the World Health Organization age‐friendly cities framework or 4Ms framework for age‐friendly care. Despite the many benefits of age‐friendly systems, we must acknowledge limitations of the evidence base, pursue opportunities to examine organizational metrics to support implementation and sustainability of age‐friendly systems, and leverage improvements in age‐friendliness at a community level.
Hypothyroidism in induction chemotherapy of children with acute lymphoblastic leukaemia: A single‐centre study
Authors: Yu Hui , Han Juan , Wu Xiaoyan , Qiu Yining , Yu Hui , Xu Jiawei , Hao Jinjin , Peng Yun , Jin Runming , Zhou Fen 
Published: May 2023

AbstractHypothyroidism as a long‐term complication in cancer survivors has been an issue, but few studies have focused on changes in thyroid hormone levels during chemotherapy for leukaemia. This retrospective study was conducted to assess the characteristics of children with acute lymphoblastic leukaemia (ALL) and hypothyroidism during induction chemotherapy and to investigate the prognostic value of hypothyroidism in ALL. Patients with a detailed thyroid hormone profile at ALL diagnosis were enrolled. Hypothyroidism was defined as low serum levels of free tetraiodothyronine (FT4) and/or free triiodothyronine (FT3). The Kaplan‐Meier method was used to create survival curves, and multivariate Cox regression analysis was used to screen prognostic factors associated with progression‐free survival (PFS) and overall survival (OS). There were 276 children eligible for the study, and 184 patients (66.67%) were diagnosed with hypothyroidism, including 90 cases (48.91%) with functional central hypothyroidism and 82 cases (44.57%) with low T3 syndrome. Hypothyroidism was correlated with the dosages of L‐Asparaginase (L‐Asp) (P = .004) and glucocorticoids (P = .010), central nervous system (CNS) status (P = .012), number of severe infections (grade 3, 4 or 5) (P = .026) and serum albumin level (P = .032). Hypothyroidism was an independent prognostic factor for PFS in ALL children (P = .024, 95% CI: 1.1‐4.1). We conclude that hypothyroidism is commonly present in ALL children during induction remission, which is related to chemotherapy drugs and severe infections. Hypothyroidism was a predictor of poor prognosis in childhood ALL.
Herd health: approach to assessing fertility data quality
Authors: Reynolds Jessica , Hudson Chris 
Published: May 2023

Background: Farm animal veterinarians are increasingly using routinely collected farm data to assess performance and enable implementation of preventive management changes on farm. Furthermore, the significance of data collection and data management to the farming industry and the farmer‐vet relationship has been identified as a key component of the future cattle veterinary practitioner role in the UK.Aim of the article: This article provides an overview of commonly recorded key performance indicators of herd fertility, and guides practitioners on how to assess the quality of such recorded data so that they can undertake meaningful data analyses.
Effective injection of adversarial botnet attacks in IoT ecosystem using evolutionary computing
Authors: Bhale Pradeepkumar , Biswas Santosh , Nandi Sukumar 
Published: May 2023

AbstractWith the widespread adoption of Internet of Things (IoT) technologies, botnet attacks have become the most prevalent cyberattack. In order to combat botnet attacks, there has been a considerable amount of research on botnet attacks in IoT ecosystems by graph‐based machine learning (GML). The majority of GML models are vulnerable to adversarial attacks (ADAs). These ADAs were created to assess the robustness of existing ML‐based security solutions. In this letter, we present a novel adversarial botnet attack (ADBA) that modifies the graph data structure using genetic algorithms (GAs) to trick the graph‐based botnet attack detection system. According to the experiment results and comparative analysis, the proposed ADBA can be executed on resource‐constrained IoT nodes. It offers a substantial performance gain of 2.15 s, 52 kb, 92 817 mJ, 97.8%, and 27.74%–41.82% over other approaches in term of Computing Time (CT), Memory Usage (MU), Energy Usage (EU), Attack Success Rate (ASR) and Accuracy (ACC) metrics, respectively.
The value of product attributes for farmed oysters: A hedonic price analysis of US restaurant menus
Authors: Botta Robert , Garlock Taryn , Asche Frank , Camp Edward V. , Ropicki Andrew 
Published: May 2023

AbstractThe price of most food products is a function of attributes related to the product itself and signals associated with product features. Using a novel data source, online restaurant menus, this study examines the impact of various attributes on raw, half shell oyster prices in the United States. We find that oyster value is significantly affected by region, as well as the amount and type of information provided. West coast oysters, oysters sold in the Pacific region, and oysters sold on menus with additional information receive the highest price premiums. These findings suggest significant market segmentation exists within the United States.
Luminescent bis‐alkynylgold(III) complexes with bidentate cyclometalating ligands: A comparison study with related tridentate cyclometalated complexes
Authors: Au Vonika Ka‐Man , Yam Vivian Wing‐Wah 
Published: May 2023

AbstractBackgroundThere has been a continuous interest in the development of luminescent gold(III) complexes as emitters for OLED applications in recent years.ObjectiveTo design and synthesize a series of luminescent bis‐alkynylgold(III) complexes with bidentate C^N‐type ligands and to compare their properties with related tridentate cyclometalated complexes.MethodsA series of bis‐alkynylgold(III) complexes with bidentate C^N‐type ligands derived from 2‐phenylpyridine and 7,8‐benzoquinoline has been designed and synthesized. The photophysical properties of the complexes have been studied by electronic absorption and emission spectroscopies.ResultsAll of the complexes were observed to exhibit rich photophysical and electrochemical properties. In particular, the complexes were strongly emissive at ambient conditions, showing vibronic‐structured emission bands peaked at 433–557 nm in dichloromethane solutions at 298 K.ConclusionsBy comparing the structural features, luminescence properties and electrochemistry of the bidentate complexes with related tridentate C^N^C and C^N^N‐type alkynylgold(III) complexes, a better understanding on the structure‐property relationship of the alkynylgold(III) system has been obtained.
Bioethanol production from sorghum grain with Zymomonas mobilis: increasing the yield and quality of raw distillates
Authors: Szambelan Katarzyna , Szwengiel Artur , Nowak Jacek , Frankowski Jakub , Jeleń Henryk 
Published: May 2023

AbstractBACKGROUNDThe present study aimed to demonstrate the superiority of bioethanol yield and its quality from sorghum using the granular starch degrading enzyme Stargen™ 002 over simultaneous saccharification and fermentation, and separate hydrolysis and fermentation using Zymomonas mobilis CCM 3881 and Ethanol Red® yeast.RESULTSBacteria were found to produce ethanol at higher yield than the yeast in all fermentations. The highest ethanol yield was obtained with Z. mobilis during 48 h of simultaneous saccharification and fermentation (83.85% theoretical yield) and fermentation with Stargen™ 002 (81.27% theoretical yield). Pre‐liquefaction in fermentation with Stargen™ 002 did not improve ethanol yields for both Z. mobilis and Saccharomyces cerevisiae. Chromatographic analysis showed twice less total volatile compounds in distillates obtained after bacterial (3.29–5.54 g L−1) than after yeast (7.84–9.75 g L−1) fermentations. Distillates obtained after bacterial fermentation were characterized by high level of aldehydes (up to 65% of total volatiles) and distillates obtained after yeast fermentation of higher alcohols (up to 95% of total volatiles). The process of fermentation using granular starch hydrolyzing enzyme cocktail Stargen™ 002 resulted in low amounts of all volatile compounds in distillates obtained after bacterial fermentation, but the highest amounts in distillates obtained after yeast fermentation.CONCLUSIONThe present study emphasizes the great potential of bioethanol production from sorghum with Z. mobilis using granular starch hydrolyzing enzyme Stargen™ 002, which leads to reduced water and energy consumption, especially when energy sources are strongly related to global climate change. © 2023 Society of Chemical Industry.
Method validation for detection of afidopyropen and M440I007 in tea
Authors: Guo Mingming , Qin Yujie , Sun Hezhi , Li Zhaoqun , Zhang Xinzhong , Wang Xinru , Yang Mei , Luo Fengjian , Chen Zongmao , Zhou Li 
Published: May 2023

AbstractBACKGROUNDAfidopyropen is a novel biorational insecticide for controlling piercing pests with great potential for application in tea gardens that can form the metabolite M440I007 when utilized for crops. However, because of a lack of analytical method for afidopyropen and M440I007 in tea, there is no means of monitoring the residues. Therefore, method development, validation and simultaneous determination of afidopyropen and M440I007 in fresh tea leaves, dried tea and tea infusion is of prime significance.RESULTSA TPT cartridge‐based method was developed for the solid phase extraction of afidopyropen and M440I007 from tea matrices. Extraction and clean‐up conditions, including the composition, volume and temperature of elutions, were optimized to achieve the best results. Both targets were extracted using water and acetonitrile, with a water:acetonitrile (v/v) ratio of 4:10 for fresh leaves and 8:10 for dried tea, which were then cleaned and analyzed using ultraperformance liquid chromatography‐tandem mass spectrometry. Both analytes demonstrated excellent linearity with a correlation coefficient above 0.998. The optimized analytical method offered limits of quantifications of 0.005, 0.005 and 0.002 mg kg−1 (converted to dried tea) in fresh tea shoots, dried tea and tea infusion for both targets, respectively. Average recoveries of afidopyropen and M440I007 ranged from 79.0% to 101.5%, with relative standard deviations ≤ 14.7%.CONCLUSIONThe results showed that the method of determination for these insecticides in tea matrices was practical and efficient. © 2023 Society of Chemical Industry.
In vitro coupled motions of the whole human thoracic and lumbar spine with rib cage
Authors: Orbach Mattan R. , Mahoney Jonathan , Bucklen Brandon S. , Balasubramanian Sriram 
Published: May 2023

AbstractStudy designIn vitro biomechanical study investigating the coupled motions of the whole normative human thoracic spine (TS) and lumbar spine (LS) with rib cage.ObjectiveTo quantify the region‐specific coupled motion patterns and magnitudes of the TS, thoracolumbar junction (TLJ), and LS simultaneously.BackgroundStudying spinal coupled motions is important in understanding the development of complex spinal deformities and providing data for validating computational models. However, coupled motion patterns reported in vitro are controversial, and no quantitative data on region‐specific coupled motions of the whole human TS and LS are available.MethodsPure, unconstrained bending moments of 8 Nm were applied to seven fresh‐frozen human cadaveric TS and LS specimens (mean age: 70.3 ± 11.3 years) with rib cages to elicit flexion‐extension (FE), lateral bending (LB), and axial rotation (AR). During each primary motion, region‐specific rotational range of motion (ROM) data were captured.ResultsNo statistically significant, consistent coupled motion patterns were observed during primary FE. During primary LB, there was significant (p < 0.05) ipsilateral AR in the TS and a general pattern of contralateral coupled AR in the TLJ and LS. There was also a tendency for the TS to extend and the LS to flex. During primary AR, significant coupled LB was ipsilateral in the TS and contralateral in both the TLJ and LS. Significant coupled flexion in the LS was also observed. Coupled LB and AR ROMs were not significantly different between the TS and LS or from one another.ConclusionsThe findings support evidence of consistent coupled motion patterns of the TS and LS during LB and AR. These novel data may serve as reference for computational model validations and future in vitro studies investigating spinal deformities and implants.
Creating an Inexpensive PVC Shoulder Model for the Training of Ultrasound‐Guided Posterior Glenohumeral Joint Injections
Authors: Melanson Joshua , Davidson Skylar , McDermott Ryland , Doyle Nora 
Published: May 2023

ObjectivesUltrasound‐guided injections are used to treat common shoulder pathologies and have been shown to be more accurate and effective than traditional landmark‐guided procedures. Currently, there exists no inexpensive shoulder model that accurately simulates the anatomical structures of the shoulder while also facilitating glenohumeral joint (GHJ) injection. Our model is an alternative to the traditional bedside training and provides a low‐risk training environment.MethodsWe created this model from easily accessible materials. Polyvinyl chloride pipe was used to create the skeletal infrastructure pectoral girdle. A detergent pod was used to represent the GHJ space. Steaks were used to simulate the infraspinatus and deltoid muscles, with meat glue as a fascial layer between the two simulated muscles. Total cost of materials for the model was $19.71.ResultsOur model successfully replicates known anatomical features of the GHJ. Additionally, the model facilitates injection into a GHJ space, representing a GHJ injection. Our model was replicated to train medical student practitioners during five different educational sessions. The model was validated through comparison to standardized educational ultrasound training videos. It was further validated by ultrasound experts.ConclusionsThe shoulder model we created is effective in simulating GHJ injections under ultrasound guidance. It simulates realistic muscle and bony landmarks both for ultrasound imaging and injection feel. Importantly, it is inexpensive and easy to replicate allowing more access to medical practitioners and students to be educated on the procedure.
Multidecadal changes in ocean transparency: Decrease in a coastal upwelling region and increase offshore
Authors: Kahru Mati , Lee Zhongping , Ohman Mark D. 
Published: May 2023

AbstractDetection of the effects of climate change on ocean ecosystems is often limited by the short duration of available time series. Here, we use ocean transparency measurements (the Secchi disk depth, ZSD) in the California Current Ecosystem since 1949 and combine them with satellite estimates. Historic in situ measurements of ZSD were irregular in space and time and are difficult to interpret in time series due to biases introduced by changing locations and timing. We normalize historic ZSD measurements with satellite‐derived mean climatology and create a merged in situ—satellite time series of ZSD for the last ~ 73 yr. Although interannual variability in ZSD is dominated by El Niño Southern Oscillation‐related variability (~ 50% of the total variance in many areas), a secular trend of decreasing transparency that is correlated with increasing productivity is detected 0–300 km from the coast in an area affected by coastal upwelling north of 27°N. In contrast, increasing transparency (correlated with decreasing productivity) is detected offshore (> 1000 km from the coast). In addition to those general trends, transparency is also increasing in coastal area off Baja California south of 27°N.
Obesity, stigma, and person‐centered language: A serial cross‐sectional analysis of scientific literature
Authors: Griffin Zachary , Long Piper , Peña Andriana , Jacobsen Samuel , Johnson Austin L. , Ottwell Ryan , Torgerson Trevor , Walters Corbin , Ghebrehiwet Merhawit , Vassar Matt , Hartwell Micah 
Published: May 2023

AbstractObjectiveLanguage can influence societal perceptions of medical conditions. The employment of person‐centered language (PCL) in health care is reflected in many scientific publications; however, the extent of this adaptation in reference to obesity is unknown.MethodsThis cross‐sectional analysis included a systematic search of PubMed obesity‐related articles across four cohorts spanning January 2004 through December 2006; January 2008 through December 2010; January 2015 through December 2018; and January 2019 through May 2020, respectively. Approximately 1971 publications were screened and examined for prespecified, non‐PCL terminology set forth by the American Medical Association Manual of Style and the International Committee of Medical Journal Editors, of which 991 were retained. Statistical analysis demonstrating PCL and non‐PCL findings was then performed. Incidence rates and cohort classifications were reported.ResultsOf the 991 articles examined, it was found that 24.02% of publications adhered to PCL. Similar adherence was observed across obesity‐specific, general medicine, and nutrition journals. PCL adherence increased over time. The most common non‐PCL label was “obese,” occurring in 75.48% of articles.ConclusionsThis investigation showed that non‐PCL in reference to obesity is widely evident in weight‐focused journals despite recommendations for adherence to PCL guidelines. Continued use of non‐PCL in reference to obesity in research may inadvertently perpetuate weight‐based stigma and health disparities in future generations.
Moral distress and ethical climate in pediatric oncology care impact healthcare professionals' intentions to leave
Authors: Ventovaara Päivi , af Sandeberg Margareta , Blomgren Klas , Pergert Pernilla 
Published: May 2023

AbstractObjectiveTo assess perceptions of ethical climate, experiences of moral distress, and intentions to leave among healthcare professionals in Nordic pediatric oncology care.MethodsA cross‐sectional survey with registered nurses, physicians, and nursing assistants at 20 Nordic pediatric cancer centers. Data were collected by using translated versions of the Swedish Hospital Ethical Climate Survey‐Shortened and the Swedish Moral Distress Scale‐Revised. Descriptive analyses and non‐parametric tests were used to describe, summarize, and compare data.ResultsAccording to 543 healthcare professionals (response rate 58%), the ethical climate in Nordic pediatric oncology care was positive. Inadequate staffing levels, poor continuity and lack of time were the most common causes of moral distress. Registered nurses experienced significantly higher levels of moral distress compared to physicians and nursing assistants. About 6% of the respondents considered leaving due to moral distress. Typically, they assessed the ethical climate as less positive and reported higher levels of moral distress than those who had no intention to leave.ConclusionsOrganizational actions that ensure safe staffing levels and improve the continuity of care are needed to prevent moral distress and high staff turnover.
Substrate binding in the allosteric site mimics homotropic cooperativity in the SIS‐fold glucosamine‐6‐phosphate deaminases
Authors: Marcos‐Viquez Jorge , Rodríguez‐Hernández Annia , Álvarez‐Añorve Laura I. , Medina‐García Andrea , Plumbridge Jacqueline , Calcagno Mario L. , Rodríguez‐Romero Adela , Bustos‐Jaimes Ismael 
Published: May 2023

AbstractGlucosamine‐6‐phosphate (GlcN6P) deaminases from Escherichia coli (EcNagBI) and Shewanella denitrificans (SdNagBII) are special examples of what constitute nonhomologous isofunctional enzymes due to their convergence, not only in catalysis, but also in cooperativity and allosteric properties. Additionally, we found that the sigmoidal kinetics of SdNagBII cannot be explained by the existing models of homotropic activation. This study describes the regulatory mechanism of SdNagBII using enzyme kinetics, isothermal titration calorimetry (ITC), and X‐ray crystallography. ITC experiments revealed two different binding sites with distinctive thermodynamic signatures: a single binding site per monomer for the allosteric activator N‐acetylglucosamine 6‐phosphate (GlcNAc6P) and two binding sites per monomer for the transition‐state analog 2‐amino‐2‐deoxy‐D‐glucitol 6‐phosphate (GlcNol6P). Crystallographic data demonstrated the existence of an unusual allosteric site that can bind both GlcNAc6P and GlcNol6P, implying that the homotropic activation of this enzyme arises from the occupation of the allosteric site by the substrate. In this work we describe the presence of this novel allosteric site in the SIS‐fold deaminases, which is responsible for the homotropic and heterotropic activation of SdNagBII by GlcN6P and GlcNAc6P, respectively. This study unveils an original mechanism to generate a high degree of homotropic activation in SdNagBII, mimicking the allosteric and cooperative properties of hexameric EcNagBI but with a reduced number of subunits.