bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the burden of patients with psoriasis through the concept of cumulative life course impairment: A narrative literature review
Authors: Crochard Anne , Gherardi Alexandre , Hueber Kollen Mélanie , Issa Seham , Villani Axel 
Published: May 2023

AbstractPsoriasis can affect diverse facets of patients' lives over time and may lead to irreversible cumulative life course impairment (CLCI). The CLCI concept initially described in 2010 in the context of psoriasis encompasses the intricate interaction between physical, psychological, social and economic burden and is influenced by several factors such as coping mechanisms, personality and external factors. CLCI assessment is conducted to characterise and ultimately mitigate or prevent the patient's burden over the life course. This review aims to give a comprehensive overview of the development and use of the CLCI concept in psoriasis since its inception. A narrative literature review was conducted from 2010 to 2022 and included 19 publications. As original studies on CLCI are scarce, this review primarily relied on case studies and those without longitudinal assessment. The core components of CLCI burden identified in patients' narratives include physical impairment, psychological impairment, stigma, socioeconomic burden and modulating factors. Modulating factors are crucial to mitigate the burden but are not equally explored. The burden associated with psoriasis stands across all dimensions covered by CLCI, thus confirming its suitability in clinical management and future studies. A better understanding of CLCI can support physicians and researchers in improving patients' lives and raising awareness on the necessity to develop early, efficient and patient‐centric interventions. The practical and systematic adoption of CLCI yet relies on the development and psychometric validation of a questionnaire that measures it.
Recent Trends in Macromolecule‐Based Approaches for Hair Loss Treatment
Authors: Kang Moon Sung , Park Tae Eon , Jo Hyo Jung , Kang Min Seok , Lee Su Bin , Hong Suck Won , Kim Ki Su , Han Dong‐Wook 
Published: May 2023

AbstractMacromolecules are large, complex molecules composed of smaller subunits known as monomers. The four primary categories of macromolecules found in living organisms are carbohydrates, lipids, proteins, and nucleic acids; they also encompass a broad range of natural and synthetic polymers. Recent studies have shown that biologically active macromolecules can help regenerate hair, providing a potential solution for current hair regeneration therapies. This review examines the latest developments in the use of macromolecules for the treatment of hair loss. The fundamental principles of hair follicle (HF) morphogenesis, hair shaft (HS) development, hair cycle regulation, and alopecia have been introduced. Microneedle (MN) and nanoparticle (NP) delivery systems are innovative treatments for hair loss. Additionally, the application of macromolecule‐based tissue‐engineered scaffolds for the in vitro and in vivo neogenesis of HFs is discussed. Furthermore, a new research direction is explored wherein artificial skin platforms are adopted as a promising screening method for hair loss treatment drugs. Through these multifaceted approaches, promising aspects of macromolecules for future hair loss treatments are identified.
Extreme points in Orlicz spaces equipped with s‐norms and closedness
Authors: Başar Esra , Öztop Serap , Uysal Badik Hüseyin , Yaşar Şeyma 
Published: May 2023

AbstractLet Φ be an Orlicz function and be the corresponding Orlicz space on a non‐atomic, σ‐finite, complete measure space . We describe the extreme points of unit ball of Orlicz spaces equipped with the s‐norm. We also investigate the closedness of the set of extreme points of unit ball. Our study generalizes and unifies the results that have been obtained for the Orlicz norm, the Luxemburg norm and the p‐Amemiya norm separately. We further classify the outer functions that generate s‐norms with respect to a constant.
Isoliquiritigenin inhibits circ0030018 to suppress glioma tumorigenesis via the miR‐1236/HER2 signaling pathway
Authors: Liu Aiqun , Jiang Baohong , Song Cailu , Zhong Qizhi , Mo Yufan , Yang Ruiqin , Chen Ciyu , Peng Cheng , Peng Fu , Tang Hailin 
Published: May 2023

AbstractIn the central nervous system diseases, glioma is one of the most common malignancies around the world. Despite the recent improvements in therapies for glioma, the prognosis of some high‐risk glioma remains poor. In glioma, isoliquiritigenin (ISL) is reported to have antioxidative and antitumor activities. However, the potential mechanisms between ISL and circle RNAs (circRNAs) in the glioma tumorigenesis process have not yet been reported. Here, we treated glioma cells with ISL, and circRNA expression levels were detected. Circ0030018 was found significantly downregulated by ISL. Therefore, we explored circ0030018 expression profiles and functions in glioma, finding that circ0030018 was evidently overexpressed in glioma cell lines. Colony formation, CCK‐8, and transwell assay made clear that circ0030018 silencing dramatically cut down glioma growth and invasion. Moreover, ROS level was detected to find that circ0030018 silence remarkably enhanced cell oxidative stress in glioma. Mechanism studies were conducted to investigate the underlying basis of circ0030018 function in glioma, unveiling that circ0030018 realized its functions partially through the miR‐1236/HER2 signaling in glioma. In conclusion, our study investigated the roles and mechanisms of the ISL on the circ0030018/miR‐1236/HER2 pathway in glioma tumorigenesis and progression. Circ0030018 could act as the prospective biologic signature or therapeutic target for glioma.
Pay or nudge employees into change? A theoretical and experimental investigation of the effect of nudging for organizational change
Authors: Müller Marvin M. , Böhm Kim Leonardo , Renz Erich 
Published: May 2023

AbstractOrganizational change often fails due to employees' resistance to change resulting in unforeseen expenses, delays, or other disruptions in organizations. In our experiment, we compare behavioral interventions—a pro‐change default rule and a pro‐change recommendation—with a costly pay raise to foster supportive behavior. In regard to the pure nudge used (default), we support its effectiveness in enhancing change‐related success. In line with our model and based on the assumption of low decision confidence in change settings, we find that a preference nudge (recommendation) lacks a corresponding effect. In addition, we find that a pay raise has a positive effect that is likely to be triggered by positive reciprocity. If this pay raise fails to materialize, we report supporting evidence for negative reciprocity. We compare the effect sizes for these nudges and the pay raise and provide insights for the relative cost‐effectiveness of such nudges compared to a pay raise for organizational change. We conclude with managerial implications.
Impact of COVID‐19 pandemic on delivery of pediatric radiotherapy: A critical review
Authors: Ali Naba , Ghalibafian Mithra , Sykes‐Martin Katherine , Parkes Jeannette , Qureshi Bilal , Esiashvili Natia 
Published: May 2023

AbstractThe COVID‐19 pandemic has prevented the timely diagnosis and treatment of many diseases, including pediatric cancer. Its impact on pediatric oncologic treatments warrants investigation. As radiotherapy is an integral component of cancer care, we reviewed the published data regarding the impact of COVID‐19 on the delivery of pediatric radiotherapy to inform actions for future global events. We found that disruptions in radiotherapy were reported amongst interruptions in other therapies. Disruptions were more common in low‐income countries (78%) and low middle‐income countries (68%) compared with upper middle‐income countries (46%) and high‐income countries (10%). Several papers included recommendations for mitigation strategies. Altered treatment regimens were common, including increasing the use of active surveillance and systemic therapy to delay local therapies, and accelerated/hypofractionated dose delivery. Our findings suggest that COVID‐19 has impacted radiotherapy delivery in the pediatric population globally. Countries with limited resources may be more affected. Various mitigation strategies have been developed. The efficacy of mitigation measures warrants further investigation.
Microwave heating of graphene nanoplatelet polymer composites: Experimental and finite element study
Authors: Dua Mahima , Zhang Qi , Mertiny Pierre 
Published: May 2023

AbstractCompared with contemporary electrofusion techniques that use embedded wires for Joule heating, microwave heating may facilitate the joining of thermoplastic polymer components, promising shortened fusion periods, superior heating uniformity, and reduced energy consumption. This study investigates the fabrication of multifunctional polylactide acid (PLA) composites with strong microwave absorption using graphene nanoplatelets (GNP). GNP/PLA nanocomposites were fabricated using a two‐step scalable manufacturing method, that is, solution blending and hot compression molding. The GNP content of the composites ranged from 0% to 8% by weight. The samples were characterized for dielectric permittivity, heat capacity, and electrical and thermal conductivity. Thermal imaging was used to investigate the efficacy of microwave heating in GNP/PLA nanocomposites as a function of microwave power and filler weight fractions. The microwave heating process in GNP composites was studied using multi‐physics finite element software. The experimental results were compared to numerical model predictions for maximum temperature and microwave energy absorbed. The produced nanocomposites were discovered to have strong microwave absorption characteristics and hence rapid heating, making this type of composite a prospective choice for gasket materials that facilitate fusion bonding for thermoplastic‐based components via localized heating.
Big versus small: The impact of aggregate size in disease
Authors: Hnath Brianna , Chen Jiaxing , Reynolds Joshua , Choi Esther , Wang Jian , Zhang Dongyan , Sha Congzhou M. , Dokholyan Nikolay V. 
Published: May 2023

AbstractProtein aggregation results in an array of different size soluble oligomers and larger insoluble fibrils. Insoluble fibrils were originally thought to cause neuronal cell deaths in neurodegenerative diseases due to their prevalence in tissue samples and disease models. Despite recent studies demonstrating the toxicity associated with soluble oligomers, many therapeutic strategies still focus on fibrils or consider all types of aggregates as one group. Oligomers and fibrils require different modeling and therapeutic strategies, targeting the toxic species is crucial for successful study and therapeutic development. Here, we review the role of different‐size aggregates in disease, and how factors contributing to aggregation (mutations, metals, post‐translational modifications, and lipid interactions) may promote oligomers opposed to fibrils. We review two different computational modeling strategies (molecular dynamics and kinetic modeling) and how they are used to model both oligomers and fibrils. Finally, we outline the current therapeutic strategies targeting aggregating proteins and their strengths and weaknesses for targeting oligomers versus fibrils. Altogether, we aim to highlight the importance of distinguishing the difference between oligomers and fibrils and determining which species is toxic when modeling and creating therapeutics for protein aggregation in disease.
HspB8 interacts with BAG3 in a “native‐like” conformation forming a complex that displays chaperone‐like activity
Authors: Sciandrone Barbara , Ami Diletta , D'Urzo Annalisa , Angeli Elena , Relini Annalisa , Vanoni Marco , Natalello Antonino , Regonesi Maria Elena 
Published: May 2023

AbstractThe HspB8‐BAG3 complex plays an important role in the protein quality control acting alone or within multi‐components complexes. To clarify the mechanism underlying its activity, in this work we used biochemical and biophysical approaches to study the tendency of both proteins to auto‐assemble and to form the complex. Solubility and Thioflavin T assays, Fourier transform infrared spectroscopy and atomic force microscopy analyses clearly showed the tendency of HspB8 to self‐assemble at high concentration and to form oligomers in a “native‐like” conformation; otherwise, BAG3 aggregates poorly. Noteworthy, also HspB8 and BAG3 associate in a “native‐like” conformation, forming a stable complex. Furthermore, the high difference between dissociation constant values of HspB8‐HspB8 interaction with respect to the binding to BAG3 obtained by surface plasmon resonance confirms that HspB8 is an obligated partner of BAG3 in vivo. Lastly, both proteins alone or in the complex are able to bind and affect the aggregation of the Josephin domain, the structured domain that triggers the ataxin‐3 fibrillation. In particular, the complex displayed higher activity than HspB8 alone. All this considered, we can assert that the two proteins form a stable assembly with chaperone‐like activity that could contribute to the physiological role of the complex in vivo.
Coconut oil derived five‐component synthetic oviposition deterrent for oriental fruit fly,Bactrocera dorsalis
Authors: Roh Gwang Hyun , Kendra Paul E. , Zhu Junwei J. , Roda Amy , Loeb Gregory M. , Tay Jia‐Wei , Cha Dong H. 
Published: May 2023

AbstractBACKGROUNDBactrocera dorsalis, oriental fruit fly (OFF), is one of the most destructive agricultural pests. Although bait sprays can effectively control OFF,resistance development has been a concern. We evaluated the oviposition deterrent activity of coconut free fatty acids (CFFA), a mixture of eight coconut oil‐derived fatty acids known to repel hematophagous insects and deter their feeding and oviposition, against OFF females.RESULTSIn laboratory 72‐h two‐choice assays using guava‐juice infused‐agar as an oviposition substrate, CFFA deterred OFF oviposition in a dose‐dependent manner with the greatest reduction of 87% at 20 mg dose compared to the control. When the eight CFFA components were tested individually, four compounds (caprylic, capric, oleic, and linoleic acids) significantly reduced OFF oviposition (‘negative‐compounds’), two (lauric and myristic acids) had no effect (‘neutral‐compounds’), and two (palmitic and stearic acids) stimulated OFF oviposition (‘positive‐compounds’). In two‐choice tests, the ‘negative‐compounds’ blend failed to elicit the same level of oviposition reduction as CFFA at equivalent concentrations found in CFFA. Adding the two ‘neutral‐compounds’ recovered the oviposition deterrence similar to CFFA. Subsequent subtraction tests showed that four ‘negative‐compounds’ plus lauric acid was as effective as CFFA in reducing OFF oviposition in guava‐juice agar. This five‐component key‐deterrent blend also reduced OFF oviposition by 95 and 72% on papaya and tomato fruit, respectively.CONCLUSIONCFFA acts as an oviposition deterrent for OFF. Given that CFFA compounds are generally regarded as safe for humans and the environment, CFFA and its bioactive components have potential use in behavioral control strategies against OFF. © 2023 Society of Chemical Industry. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Hybrid dynamic event‐triggered fault control of positive Markovian jump systems
Authors: Zhang Junfeng , Zhang Suhuan , Zheng Gang 
Published: May 2023

AbstractThis paper presents a new hybrid dynamic event‐triggered control framework on positive Markovian jump systems in continuous‐ and discrete‐time contexts subject to actuator fault. First, a new hybrid dynamic event‐triggering mechanism consists of two types of conditions: One is a dynamic event‐triggering condition associated to dynamic variable and the other one is a static event‐triggering condition. Under the new triggering mechanism, an interval approach is introduced to assist the control design, for which the lower and upper bounds of the original system are obtained. A nonfragile controller is proposed for stochastic stability of the underlying continuous‐time system with actuator fault by virtue of stochastic copositive Lyapunov functions. Under the designed controller, the positivity and stability of the system are achieved by guaranteeing the positivity and stability of the lower and upper bound systems, respectively. Moreover, a hybrid dynamic event‐triggered mechanism is established for discrete‐time systems. A nonfragile hybrid dynamic event‐triggered control is explored for discrete‐time positive Markovian jump systems. All the conditions can be solved by linear programming. Finally, two examples are given to verify the validity of the proposed design.
Use of Airborne Laser Scanning to assess effects of understorey vegetation structure on nest‐site selection and breeding performance in an Australian passerine bird
Authors: Turner Richard S. , Lasne Ophélie J. D. , Youngentob Kara N. , Shokirov Shukhrat , Osmond Helen L. , Kruuk Loeske E. B. 
Published: May 2023

AbstractIn wild bird populations, the structure of vegetation around nest‐sites can influence the risk of predation of dependent offspring, generating selection for nest‐sites with vegetation characteristics associated with lower predation rates. However, vegetation structure can be difficult to quantify objectively in the field, which might explain why there remains a general lack of understanding of which characteristics are most important in determining predation rates. Airborne laser scanning (ALS) offers a powerful means of measuring vegetation structure at unprecedented resolution. Here, we combined ALS with 11 years of breeding data from a wild population of superb fairy‐wrensMalurus cyaneusin southeastern Australia, a species which nests relatively close to the ground and has high rates of nest and fledgling predation. We derived structural measurements of understorey (0–8 m) vegetation from a contiguous grid of 30 × 30 m resolution cells across ourc.65 hectares study area. We found that cells with nests (nest‐cells) differed in their understorey vegetation structure characteristics compared to unused cells, primarily in having denser vegetation in the lowest layer of the understorey (0–2 m; the ‘groundstorey’ layer). The average height of understorey vegetation was also lower in cells with nests than in those without nests. However, relationships between understorey vegetation structure characteristics and breeding performance were mixed. Nest success rates decreased with higher volumes of groundstorey vegetation, as did fledgling survival rates, though only in nest‐cells with lower height vegetation. Our results indicate that ALS can identify vegetation characteristics relevant for superb fairy‐wren nest‐site selection, but that nesting preferences are not beneficial under current predation pressures. The study illustrates the potential for using ALS to investigate how ecological conditions affect behaviour and life‐histories in wild animal populations.
Professional development as Praxis: EFL teachers' challenges in learning to implement dynamic assessment of writing
Authors: Faryabi Fatemeh , Rahimi Mohammad , Davin Kristin J. 
Published: May 2023

AbstractThe present study adopted a praxis orientation to second language (L2) research and pedagogy to explore the professional development needs of three English as a foreign language (EFL) teachers after their first attempt at implementing dynamic assessment (DA) of essay writing. To date, few studies have examined how teachers learn to implement DA, especially in a context like Iran where the educational system has historically centered upon high‐stakes assessments of learning (Rezagah, 2022). This study sought to understand how existing models of DA professional development could be modified to prepare teachers to implement DA of essay writing through written mediation. Findings revealed three challenges that arose for teachers during their initial attempts at DA implementation: 1) choosing an appropriate target for mediation, 2) delivering graduated mediation, and 3) dedicating sufficient time to the process of DA. We outline each of these three challenges in the findings of this article and their correspondent suggestions for revised future professional development of DA of writing.
Technological options and design evolution for recycling spent lithium‐ion batteries: Impact, challenges, and opportunities
Authors: Hossain Rumana , Sarkar Montajar , Sahajwalla Veena 
Published: May 2023

AbstractThe lithium‐ion battery (LIB) market is growing, driven by consumer demand and the imperative to reduce greenhouse gas (GHG) emissions. The socio‐environmental impacts of LIBs production are vast; thus, it is of paramount importance to acquire knowledge about the consequences of lithium metal mining on human health, farming and the overall ecosystem. The materials embedded in spent LIBs have high industrial value. To minimize environmental impacts and conserve declining natural resources, the global supply chain for the raw materials for LIBs should not rely solely on mining. Rather, manufacturers should have access to the critical materials recovered from waste, as a sustainable and reliable secondary source of valuable materials. It is also crucial to study the hazards and economic considerations associated with waste LIB management from disassembly to final recycling stage. This article evaluates and highlights various current approaches to recycling and reuse of LIBs, as well as potential future developments. The pros and cons of different technological options for recycling spent LIBs, and opportunities to use small‐scale recycling technology to overcome the associated barriers, are also discussed.This article is categorized under:

Emerging Technologies > Energy Storage
Emerging Technologies > Materials
Policy and Economics > Research and Development
Is the Trade Agreement Between the EU and Colombia Coherent with European Support for Peacebuilding?
Authors: Bidarratzaga Aurre Eduardo , Díez Ángeles Sánchez 
Published: May 2023

AbstractTrade agreements between central and peripheral countries or regional groups with very different commercial and productive specializations have been in place for several decades now, since they were first promoted in the 1990s, initially by the US government and later by the European Union (EU). This resulted in the promotion of Free Trade Agreements (FTAs) in the first case, and Association Agreements (AAs) in the second, turning different individual economies or Latin American regional groups into preferential partners in these agreements, in the latter based on a model with certain specific differentiating features.This chapter analyses the main characteristics and consequences of the Trade Agreement signed in 2012 between the EU and Colombia, as well as its future prospects in the current context. We inquire to what extent the agreement is consistent with the rest of the EU's cooperation policies, where in recent years support for peacebuilding has gained great weight from a comprehensive perspective in order to end the root factors that generate conflict and promote lasting peace and development in Colombia.
Spatial Models of Cardiac Electrophysiology
Authors: Horgmo Jæger Karoline , Tveito Aslak 
Published: May 2023

AbstractIn Chapter 8, we introduced mathematical models of the action potential across a cell membrane. Understanding the properties of the cell membrane is absolutely essential in order to understand the electrophysiology of excitable cells. However, some essential properties can only be studied in spatially resolved models; i.e., in models representing spatial variation across a single cell or a collection of cells.