bluuebunny/crossref_metadata_2025_split huggingface dataset:
Graded effects of dry-feed added sodium benzoate/ascorbic acid combination on neurobehaviour, brain markers of oxidative stress, and markers of inflammation in mice
Authors: Olofinnade Anthony Tope , Onaolapo Adejoke Yetunde , Onaolapo Olakunle James 
Published: January 2023

Abstract
Background:Controversies concerning the safety of sodium benzoate/ascorbic acid combination have remained grounds for continued scientific investigations. However, there is a dearth of scientific literature on its effect on the brain. This study investigated the effects dry-food added sodium benzoate/ascorbic acid combination on neurobehaviour, brain oxidative stress and inflammatory cytokines in mice.
Methods: Adult male mice were assigned into ten groups of 10 mice each. The groups are: one group fed standard diet, three groups fed diet containing sodium benzoate (NaB) at 125 mg/kg with ascorbic acid (AA) at 100, 200 or 300 mg/kg of feed, another three groups fed NaB at 250 mg/kg with AA at 100, 200 or 300 mg/kg of feed respectively, and the last three groups fed NaB at 500 mg/kg with AA at 100, 200 or 300 mg/kg respectively. Behavioural tests were assessed following which animals were sacrificed and their brains homogenised for the assessment of biochemical parameters. Results: The result showed a decrease in body weight, self grooming, total antioxidant capacity and inflammatory cytokines, mixed response with food intake, locomotor activity, Y maze spatial working memory and anxiety related behaviours and an increase in rearing and radial arm maze spatial working memory.
Conclusion: Dry food added NaB/AA altered behavioural, oxidative and inflammatory markers in mice. While not indicating outright deleterious effects at the concentrations used, the results suggest the need for further investigations into the effects of their combination, especially, when we consider their wide range of applications in the food industry.
Proposing magnetoimpedance effect for neuromorphic computing
Authors: Jamilpanah Loghman , Chiolerio Alessandro , Crepaldi Marco , Adamatzky Andrew , Mohseni Majid 
Published: January 2023

Abstract
Oscillation of physical parameters in materials can result in a peak signal in the frequency spectrum of the voltage measured from the materials. This spectrum and its amplitude/frequency tenability, through the application of bias voltage or current,can be used to perform neuron-like cognitive tasks. Magnetic materials, after achieving broad distribution for data storage applications in classical Von Neumann computer architectures, are under intense investigation for their neuron-like computing capabilities. A recent successful demonstration regards magnetisation oscillation in magnetic thin films by spin transfer or spin orbit torques accompanied by magnetoresistance (MR) effect that can give a voltage peak in the frequency spectrum of voltagewith bias current dependence of both peak frequency and amplitude. Here we use classical magnetoimpedance (MI) effect in amagnetic wire to produce such a peak and manipulate its frequency and amplitude by means of the bias voltage. We applied a noise signal to a magnetic wire with high magnetic permeability and owing to the frequency dependence of the magnetic permeability we got frequency dependent impedance with a peak at the maximum permeability. Frequency dependence of the MI effect results in different changes in the voltage amplitude at each frequency when a bias voltage is applied and therefore a shift in the peak position and amplitude can be obtained. The presented method and material provide optimal features instructural simplicity, low-frequency operation (tens of MHz-order) and high robustness at different environmental conditions.Our universal approach can be applied to any system with frequency dependent bias responses.
A systematic outbreak investigation of SARS-CoV-2 transmission clusters in a tertiary academic care center
Authors: von Rotz Matthias , Kuehl Richard , Durovic Ana , Zingg Sandra , Apitz Anett , Wegner Fanny , Seth-Smith Helena M.B. , Roloff Tim , Leuzinger Karoline , Hirsch Hans H , Kuster Sabine , Battegay Manuel , Mariani Luigi , Schaeren Stefan , Bassetti Stefano , Banderet-Uglioni Florian , Egli Adrian , Tschudin-Sutter Sarah 
Published: January 2023

Abstract
Background
We sought to decipher transmission pathways in healthcare-associated infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within our hospital by epidemiological work-up and complementary whole genome sequencing (WGS). We report the findings of the four largest epidemiologic clusters of SARS-CoV-2 transmission occurring during the second wave of the pandemic from 11/2020-12/2020.
Methods
At the University Hospital Basel, Switzerland, systematic outbreak investigation is initiated at detection of any nosocomial case of Coronavirus disease of 2019 (COVID-19), defined as polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infection occurring more than five days after admission. Clusters of nosocomial infections, defined as the detection of at least two positive patients and/or healthcare workers (HCWs) within one week with an epidemiological link, were further investigated by WGS on respective strains.
Results
The four epidemiologic clusters included 40 patients and 60 HCWs. Sequencing data was available for 70% of all involved cases (28 patients and 42 HCWs), confirmed epidemiologically suspected in house transmission in 33 cases (47.1% of sequenced cases) and excluded transmission in the remaining 37 cases (52.9%). Among cases with identical strains, epidemiologic work-up suggested transmission mainly through a ward-based exposure (24/33, 72.7%), more commonly affecting HCWs (16/24, 66.7%) than patients (8/24, 33.3%), followed by transmission between patients (6/33, 18.2%), and among HCWs and patients (3/33, 9.1%, respectively two HCWs and one patient).
Conclusions
Phylogenetic analyses revealed important insights into transmission pathways supporting less than 50% of epidemiologically suspected SARS-CoV-2 transmissions. The remainder of cases most likely reflect community-acquired infection randomly detected by outbreak investigation. Notably, most transmissions occurred between HCWs, possibly indicating lower perception of the risk of infection during contacts among HCWs.
The Role of Government Effectiveness in the Light of ESG Data at Global Level
Authors: Laureti Lucio , Costantiello Alberto , Leogrande Angelo 
Published: January 2023

Abstract
In this article we estimate the level of Government Effectiveness-GE in 193 countries in the period 2011-2020 using data of the ESG World Bank Database. Different econometric techniques are used i.e. Panel Data with Random Effects, Panel Data with Fixed Effects, and Pooled OLS. Results show that GE is positively related among others to “Control of Corruption”, “Political Stability and Absence of Violence/Terrorism”, and negatively associated with “Percentage Annual GDP Growth”. We perform a cluster analysis with the k-Means algorithm optimized with the Elbow Method and we find the presence of four clusters. Finally, we confront eight machine learning algorithms for the prediction of GE. Results show that the Polynomial Regression is the best predictive algorithm. The value of GE is expected to growth on average by 15.97%.
JEL CODE: D7, D70, D72, D73, D78.
Simultaneous Detection of Omicron and Other SARS-CoV-2 Variants by Multiplex PCR MassARRAY Technology
Authors: Wacharapluesadee Supaporn , Hirunpatrawong Piyapha , Petcharat Sininat , Torvorapanit Pattama , Jitsatja Anusara , Thippamom Nattakarn , Ninwattana Sasiprapa , Phanlop Chanchanit , Buathong Rome , Tangwangvivat Ratanaporn , Klungthong Chonticha , Chinnawirotpisan Piyawan , Hunsawong Taweewun , Suthum Krairerk , Komolsiri Suparerk , Jones Anthony R. , Fernandez Stefan , Putcharoen Opass 
Published: January 2023

Abstract

The rapid emergence of SARS-CoV-2 variants with high severity and transmutability adds further urgency for rapid and multiplex molecular testing to identify the variants. A nucleotide matrix-assisted laser-desorption-ionization time-of-flight mass spectrophotometry (MALDI-TOF MS)-based assay was developed (called point mutation array, PMA) to identify four major SARS-CoV-2 variants of concern (VOCs) including Alpha, Beta, Delta, and Omicron (namely PMA-ABDO) and differentiate Omicron subvariant (namely PMA-Omicron). PMA-ABDO and PMA-Omicron consist of 24 and 28 mutation sites of the spike gene. Both PMA panels specifically identified VOCs with as low as 10 viral copies/ µl. The panel has shown a 100% concordant with the Next Generation Sequencing (NGS) results testing on 256 clinical specimens with real-time PCR cycle threshold (Ct) values less than 26. It showed a higher sensitivity over NGS; 25/28 samples were positive by PMA but not NGS in the clinical samples with PCR Ct higher than 26. Due to the mass of nucleotide used to differentiate between wild-type and mutation strains, the co-infection or recombination of multiple variants can be determined by the PMA method. This method is flexible in adding a new primer set to identify a new emerging mutation site among the current circulating VOCs and the turnaround time is less than 8 hours. However, the spike gene sequencing or NGS retains the advantage of detecting newly emerged variants.
Democracy, Dictatorship and People’s beliefs: Evidence from the World Value Longitudinal Survey
Authors: Jadhav Vivek 
Published: January 2023

Abstract
The relationship that exists between economic results and political institutions has been the subject of much discussion and debate. Both the nature of political institutions and the economic outcomes have a significant impact on one another. Political institutions have a considerable influence on the outcomes of economic activity, and economic outcome has a big impact on the nature of political institutions. In addition to their effects on the economy, political institutions have the potential to shape the characteristics of social institutions via their impact on the beliefs held by the populace. This research makes use of two different worldwide data sources: World Value Longitudinal Survey and Global State of Democracy Index by International Institute for Democracy and Electoral Assistance in addition to economic data in order to gain an understanding of the differences in the beliefs and values that are held by people living in the various political regimes. There are three key findings from this study. First, as a consequence of the change in political regimes, people's perspectives on the relative merits of equality and freedom tend to change. People with higher incomes place a higher emphasis on freedom than equality under authoritarian leadership more so than those with lower incomes. Second, the available research suggests that people from high income category have a tendency to put less weight on income equality than those who have low income, and this is consistent across various kinds of regimes. Third, in a democratic society, people with lower incomes put a larger value on income equality than those with higher incomes do across all regimes.
Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane
Authors: Song Hyun Kyu , Park Si Hoon , Jeong Byung-Cheon , Song Ju Han , Jang Sehwan , Ko Young-Gyu , Park Zee Yong , Lee Kyung Eun , Han Juhyun , Jeong Hyeongseop , Hyun Jaekyung 
Published: January 2023

Abstract
Plasma membrane repair defects cause human muscle and heart diseases. In the early stage of membrane repair, TRIM72/MG53 nucleates vesicles to the damaged site within seconds. Despite the therapeutic potential of TRIM72/MG53, the molecular mechanisms are poorly understood. Here, we present the structure of TRIM72, the first complete model of a TRIM E3 ligase. Structure-guided functional analysis revealed a unique phospholipid recognition mode in which a pair of PRYSPRY domains interacts with negatively charged membranes. In subsequent biochemical analyses, the interaction between TRIM72 and the phosphatidylserine-enriched membrane was shown to be critical for both the oligomeric assembly and ubiquitination activity of TRIM72. We elucidated a higher-order model of TRIM72 assembly on the phospholipid bilayer using cryogenic electron tomography followed by subtomogram averaging. We developed a working molecular model of TRIM72 through integrated structural and biochemical techniques. The findings provide a fundamental basis for the study of TRIM E3 ligases, which share a conserved molecular architecture, and provide further insights into the general regulation of RING-type E3 ligases through the cooperation of multiple domains like those in higher-order assemblies.
Perancangan dan Implementasi Dashboard Keuangan Persekutuan Joy Indonesia dengan Metode User Centered Design
Authors: Prayoga Erwin , Delima Rosa 
Published: January 2023

Persekutuan JOY Indonesia adalah sebuah organisasi non-profit yang berada di kota Yogyakarta. Persekutuan JOY Indonesia bergerak di bidang pelayanan mahasiswa kristen dan katolik yang anggotanya merupakan mahasiswa dan mahasiswi kampus-kampus di Yogyakarta. Sumber keuangan Persekutuan JOY Indonesia sepenuhnya didukung oleh alumni organisasi ini sendiri dan donor pendukung dari Korea. Pengelolaan keuangan sepenuhnya dikerjakan oleh staf manajemen. Saat ini pengelolaan keuangan masih menggunakan excel dan pelaporan masih berbentuk file PDF yang biasa dipublikasikan pada website persekutuan tersebut setiap awal bulan. Hal tersebut membuat para alumni dan pendukung tidak mengetahui informasi penting seperti dana mana yang lebih prioritas untuk didukung atau dana mana yang belum mencapai target anggaran. Tujuan penelitian ini adalah untuk mengembangkan sebuah dashboard berbasis web dengan metode User Centered Design (UCD) yang membantu staf manajemen Persekutuan JOY Indonesia dalam pengelolaan data keuangan dan mempermudah alumni dan pendukung memonitoring keuangan persekutuan tersebut. Penelitian ini menghasilan sebuah dashboard keuangan untuk persekutuan JOY. Proses pengembangan dengan metode UCD dilakukan dalam dua iterasi. Pengujian dashboard melibatkan lima belas responden yang terdiri dari lima responden yang staf dan sepuluh responden alumni. Hasil pengujian menunjukkan bahwa dashboard efektif digunakan untuk menyajikan informasi keuangan untuk mendukung pengurus dalam pengelolaan keuangan organisasi.
The Associations Between Loneliness, Hopelessness, and Self-control and Internet Gaming Disorder Among University Students Who Were Men Who Have Sex With Men: Cross-sectional Mediation Study
Authors: Yu Yanqiu , Fong Vivian W I , Ng Joyce Hoi-Yuk , Wang Zixin , Tian Xiaobing , Lau Joseph T F 
Published: January 2023

Background
The minority stress model postulates that men who have sex with men (MSM) often encounter multiple stressors because of their sexual minority status, which may lead to psychological problems and maladaptive coping such as addictive behaviors (eg, internet gaming disorder [IGD]). It was hypothesized that hopelessness and loneliness would be associated with IGD via self-control among MSM.

Objective
This study investigated the prevalence of IGD and its associations with variables related to minority stress (loneliness and hopelessness) among MSM who were university students. Mediation involving such associations via self-control was also explored.

Methods
With informed consent, 305 MSM attending universities in Sichuan, China participated in the study. The validated Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) checklist was used to assess IGD. Multivariable logistic regression adjusted for background factors and structural equation modeling were conducted.

Results
The prevalence of IGD was 12.8% (n=39). Logistic regression found that IGD was positively associated with hopelessness and loneliness, and negatively associated with self-control. The structural equation modeling identified three significant paths between hopelessness/loneliness and IGD: (1) hopelessness → lower self-control → higher IGD (full mediation), (2) loneliness → lower self-control → higher IGD (partial mediation: effect size of 28%), and (3) a direct effect from loneliness to IGD.

Conclusions
IGD was prevalent among young MSM and warrants interventions that may try to reduce the level of psychosocial problems such as loneliness and hopelessness and improve self-control. According to the socioecological model, the promotion of social acceptance and reduction in stigma toward MSM are important in reducing loneliness and hopefulness among MSM. Self-control links up the relationships between psychosocial problems and IGD and should be given special attention. Longitudinal studies are warranted to confirm the findings and test new mediations between loneliness/hopelessness and MSM with IGD.
Influência do nível de atividade física na prevalência de excesso de peso em adolescentes escolares
Authors: Lima Giérisson Brenno Borges , Monte Juliana Luna do , Marques Raphael  Furtado , Moura Thais Norberta Bezerra de 
Published: January 2023

O aumento do excesso de peso e obesidade em crianças e adolescentes está ligado ao crescente número de casos de doenças crônicas não transmissíveis. Este estudo tem como objetivo avaliar a influência do nível de atividade física na prevalência de excesso de peso em adolescentes escolares. Trata-se de uma pesquisa transversal com abordagem quantitativa, com cinquenta escolares de ambos os sexos, na faixa etária entre 15 anos e 18 anos. O instrumento que avaliou o nível de atividade física baseou-se em questionário de um estudo prévio, além de avaliação antropométrica. Para análise estatística, utilizou-se um banco de dados eletrônico elaborado (Excel). Para verificar as diferenças entre os sexos dos grupos, foi realizado o teste t não pareado, considerando significativos os valores em que p < 0,05. Não houve diferença estatística significativa entre os sexos em relação à idade cronológica (p = 0,36858), mas houve entre a estatura dos indivíduos (p = 0,00006). Os valores referentes ao peso foram 55,5 ± 8,7 kg. No que diz respeito ao diagnóstico de Índice de Massa Corporal (IMC)/idade, observaram-se dois indivíduos com baixo peso (4%), 46 classificados como adequados ou eutróficos (92%) e dois com sobrepeso (4%). Quanto ao nível de atividade física, dos cinquenta adolescentes, 16 foram classificados como inativos (32%), sete como inadequadamente ativos (14%) e 27 ativos (54%). Conclui-se que os níveis de sobrepeso/obesidade não prevaleceram entre os adolescentes, sendo em sua maioria classificados com peso adequado ou eutrófico.
Cloud Macro-and Microphysical Properties as Coupled to Sea Ice Leads During the MOSAiC Expedition
Authors: Garfias Pablo Saavedra , Kalesse-Los Heike , Albedyll Luisa Von , Griesche Hannes , Spreen Gunnar 
Published: January 2023

This study presents the micro- and macrophysical cloud properties as a
function of their surface coupling state with the sea ice during the
wintertime of the MOSAiC field experiment. Cloud properties such as
cloud base height, liquid- and ice water content have been previously
found to have statistically distinguished features under the presence of
sea ice leads (characterized by sea ice concentration, SIC) along
downwind direction from the central observatory RV Polarstern. Those
findings are mainly in an increase of liquid water content, and favored
occurrence of low level clouds as contrasted to situations when the
clouds are thermodynamically decoupled.
The present contribution is an update considering two recent
developments in the liquid detection in clouds and in the detection of
sea ice leads. First, radar and lidar-based cloud droplet detection
approaches like Cloudnet (Illingworth et al. 2007, Tukiainen et al.
2020) using Arctic wintertime observations and applied to measurements
by the Atmospheric Radiation Measurement mobile facility (ARM)
instrumental suite on-board the RV Polarstern during MOSAiC.
Secondly, we explore a new sea ice lead fraction product based on sea
ice divergence. Sea ice divergence is estimated from sequential images
of space-borne synthetic aperture radar with a spatial resolution of 700
m. The lead divergence product, being independent of cloud coverage,
offers the unique advantage to detect opening leads at high spatial
resolution.
Statistics for the wintertime cloud properties based on the coupling
state with the sea ice concentration and sea ice lead fraction will be
presented as an approach to study Arctic clouds and their interaction
with sea ice.
Predictive Value of C-peptide Measures for Clinical Outcomes of Beta Cell Replacement Therapy in Type 1 Diabetes: Report from the Collaborative Islet Transplant Registry (CITR)
Authors: Baidal David A. , Ballou Cassandra M. , Rickels Michael R. , Berney Thierry , Pattou Francois , Payne Elizabeth H. , Barton Franca B. , Alejandro Rodolfo , Investigators the CITR 
Published: January 2023

<p> </p>
<p><strong>OBJECTIVE</strong><br>
To determine C-peptide measures and levels associated with positive glycemic control outcomes following islet transplantation (ITx) in type 1 diabetes.<br>
<br>
<strong> RESEARCH DESIGN AND METHODS</strong><br>
We evaluated Collaborative Islet Transplant Registry (CITR) Islet-Alone recipients with pre-transplant C-peptide <0.1 nmol/L and mean follow up of 4.6±1.1 years (n=677). Area under the curve of receiver-operator characteristics (ROC-AUC) were used to evaluate predictive value of fasting and stimulated glucose and C-peptide measures for 7 primary outcomes: a) absence of severe hypoglycemic events (ASHE); b) HbA1c<7.0%; c) HbA1c<7.0% & ASHE; d) HbA1c≤6.5%; e) HbA1c≤6.5% & ASHE; f) insulin independence; and g) ASHE, HbA1c≤6.5% & insulin independence (the optimal outcome). Measures with the highest ROC-AUC were selected for determination of optimal cut points. <br>
<br>
<strong> RESULTS</strong><br>
Fasting C-peptide was highly predictive for ASHE (ROC-AUC=0.906; optimal cut point=0.070 nmol/L), and the optimal outcome (ROC-AUC=0.845; optimal cut point=0.33 nmol/L). Mixed-meal tolerance test (MMTT) stimulated C-peptide to Glucose ratio (CPGR) outperformed both fasting and stimulated C-peptide for all outcomes except ASHE. Optimal cut point for the optimal outcome was 0.12 nmol/mmol for MMTT stimulated CPGR, and 0.97 nmol/L for MMTT stimulated C-peptide.</p>
<p><strong>CONCLUSION</strong><br>
Fasting C-peptide reliably predicts ITx primary outcomes. MMTT stimulated CPGR provides marginally better prediction for composite ITx outcomes, including insulin independence. In the absence of a MMTT, a fasting C-peptide ≥0.33 nmol/L is a reassuring measure of optimal islet graft function. C-peptide targets represent excellent and easily determinable means to predict glycemic control outcomes after ITx and should be considered as potential goals of beta cell replacement. </p>