bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of Mutrashmari (urolithiasis) with Palasha Kshara and Ashmarihara Kwatha
Authors: Kumari Monika , Tukaram Dudhamal 
Published: August 2023

Background:

Mutrashmari (urolithiasis), a pathological condition of the urinary system where aggregation of urinary crystalloids takes place anywhere in the urinary tract, i.e., from the kidney to urinary bladder showing male preponderance (male:female = 2:1) and now becoming medico-surgical as well as economical challenge for all health-care systems.

Aims:
The aim of this study is to evaluate the effect of Palasha Kshara (alkali) with Ashmarihara Kwatha (decoction) in the management of Mutrashmari (urolithiasis).

Materials and method:
Thirty-nine patients of Mutrashmari were selected and randomly allocated with a computerized randomized method into two groups. In trial group A (n = 20), capsule Palasha Kshara (Mridu), 500 mg three times a day after meal, and Ashmarihara Kwatha (decoction) (40 ml twice daily) were given orally after meals for 2 months. In placebo control group B (n = 19), placebo capsule (granulated wheat), was given in a dosage of 500 mg along with 3–4 l of water for 2 months.

Results:
Patients of Palasha Kshara and Ashmarihara Kwatha group showed better relief in chief complaints, i.e., pain and increased frequency of micturition as compared to the placebo group. Complete remission of symptoms of Mutrashmari was more in patients treated with Palasha Kshara with Ashmarihara decoction.

Conclusion:

Palasha Kshara with Ashmarihara Kwatha is found more effective than placebo in the management of Mutrashmari (urolithiasis).
Radiation-induced esophagitis in patients with breast cancer receiving supraclavicular nodal irradiation: A retrospective observational study
Authors: Azeez Zalfa Abdul , Fernandes Donald , Rao Sandesh B. , Krishnaraj H. , Jacob Tony , Sequeira Lanisha J. 
Published: August 2023

ABSTRACT

JOURNAL/crsat/04.03/02201859-202306020-00006/figure1/v/2023-08-03T140821Z/r/image-tiff

Background:
Radiotherapy is an important treatment modality for locally advanced breast cancer and includes irradiation of the chest wall and supraclavicular nodes, with or without the axilla. Since the esophagus is close to the supraclavicular nodes, patients may experience acute radiation esophagitis during treatment which decreases their quality of life.

Objective:
To identify the dosimetric parameters of the esophagus which may affect the occurrence of esophagitis in patients with breast cancer who received supraclavicular nodal irradiation.

Materials and Methods:
This was a single-center retrospective observational study carried out from January 2021 to June 2022 at Father Muller Medical College Hospital, Mangalore, India. We enrolled patients with histologically proven breast cancer, who had received post-mastectomy radiation to the chest wall and supraclavicular nodes to a dose of 50 Gy in 25 fractions, 2 Gy per fraction, 5 fractions per week with 6 MV photon linear accelerator by intensity modulated radiation therapy. Toxicities were recorded every week. The parameters documented included the mean esophageal dose, maximum dose to the esophagus, and length of the esophagus within the treatment area.

Results:
We enrolled 25 patients with infiltrating ductal carcinoma of the breast who had undergone mastectomy and received neoadjuvant or adjuvant chemotherapy. The median age was 53 years (IQR, 44.5-63.5). Esophagitis (any grade) was noted in 18 of the 25 patients (72%). Grade 2 esophagitis developed in all 6 patients (100%) who had received a mean esophageal dose >20 Gy, and in none of the 19 (0%) who received a dose <20 Gy; P < 0.001. The development of esophagitis was not significantly associated with the esophageal length included in the treating area (P = 0.62), the maximum dose to the esophagus (P = 0.09), V10 (P = 0.49), or V20 (P = 1). The esophageal mean dose (Dmean) was the sole predictive factor for the development of esophagitis; P = 0.04.

Conclusion:
In patients with breast cancer receiving post-mastectomy radiation to the chest wall and supraclavicular area, the mean esophageal radiation dose is the only factor that correlates with the development of esophageal toxicity. Thus, esophageal toxicity can be reduced by prescribing dose constraints to the esophagus, thereby potentially improving the quality of life of patients.
Amivantamab: A narrative drug review
Authors: John Anupa , Noronha Vanita , Singh Ajaykumar , Menon Nandini , Prabhash Kumar 
Published: August 2023

ABSTRACT
Epidermal growth factor receptor (EGFR) activating mutations are known oncogenic drivers in non-small-cell lung cancer (NSCLC), with 85% attributable to an exon 19 deletion or exon 21 L858R point substitution. The next most common is an exon 20 insertion mutation (Ex20Ins), which results in an altered active site that sterically interferes with tyrosine kinase inhibitor (TKI) binding, resulting in a poorer response rate to EGFR TKIs. Amivantamab (JNJ-61186372), a fully humanized EGFR- mesenchymal-epithelial transition receptor (MET) bispecific antibody has been approved for use in adults with locally advanced or metastatic NSCLC with EGFR Ex20Ins mutations, whose disease has progressed on or after platinum-based chemotherapy. To prepare this review, we searched various websites, including the European Medicines Agency Drug Manual, United States Food and Drug Administration, PubMed, Science Direct, and UpToDate using the search terms, “Amivantamab,” “NJ-61186372,” “amivantamab-vmjw,” and” “EGFRexon20ins.” We shortlisted 121 articles published between 2015 and 2023, of which 49 were included. This review discusses the clinical indications, adverse effects, safety, pharmacodynamics, pharmacokinetics, and the key research trials that investigated the use of amivantamab.
The prevalence of undiagnosed thalassemia minor among primigravida pregnant women before 20 weeks of gestation
Authors: Abid Sahar Jassim , Najim Israa Jameel 
Published: August 2023

ABSTRACT
Pregnancy-associated anemia is a widespread condition that can have varying impacts on both the mother and the developing fetus, depending on the level of hemoglobin in the mother’s blood and the stage of pregnancy at which the anemia occurs. In Iraq, 27% of all registered thalassemia cases are thalassemia minor. Pregnancy may aggravate mild undiagnosed thalassemia early in pregnancy. The objective of the study was to access the prevalence of undetected thalassemia minor in primigravida women who received prenatal care before 20 weeks and to compare the demographic and socioeconomic characteristic features between women with iron-deficiency anemia (IDA) and those without any anemia. A total of 298 primigravida women who attended prenatal care at 20 weeks or less were recruited and their hematocrit level was assessed. Participants were segregated into two groups regarding the presence of anemia. Patients who had packed cell volume lower than 33% underwent iron study and standard Hb electrophoresis. Information about women’s demographics, socioeconomic status, and family history of hereditary anemia were recorded. The participants had a mean age of 22.7 years, with an age range spanning from 16 to 43 years. 33.33% of 298 women had pathological anemia. All the participants exhibited microcytic anemia, with 26.85%, had confirmed IDA, whereas 6.71% had β thalassemia minor (BTM) phenotype. Both BTM and IDA patients frequently reported a positive family history of anemia at 80% and 68.7%, respectively, which was significantly greater than the control group at 39.9% (P = 0.001). No significant differences were seen between BTM and IDA in terms of age or socioeconomic status. Anemia due to undetected thalassemia minor was common among primigravida women. Screening for BTM carriers pregnant can help in monitoring their status, assessing the fetus’s risk of developing thalassemia, and making a diagnosis in communities with high rates of consanguineous marriages, such as Iraq.
Synthesis, characterization, and antiproliferative evaluation of novel sorafenib analogs for the treatment of hepatocellular carcinoma
Authors: Jihad Marwan Imad , Mahdi Monther Faisal 
Published: August 2023

ABSTRACT
Cancer is a disease triggered by an uncontrolled proliferation of a cluster of cells, typically originating from a single cell. Sorafenib, a widely utilized pharmaceutical, has limitations in clinical use due to pharmacokinetic challenges and the development of resistance mechanisms. This investigation aimed to synthesize new sorafenib analogs and evaluated their activity against HepG2 cell lines, specifically targeting hepatocellular carcinoma (HCC). Seven sorafenib analogs were synthesized and identified by Fourier-transform infrared spectroscopy and 1H-NMR spectra. Cytotoxicity of the analogs was assessed on the human HepG2 cancer cell line by (3-(4, 5-dimethylthazolk-2-yl)-2, 5-diphenyl tetrazolium bromide) colorimetric assay. Results revealed that among the studied compounds, 4b exhibited the most pronounced cytotoxicity against cancer cells, surpassing even the efficacy of sorafenib. This suggested that small substitutions on the NH moiety play a crucial role in the activity against the human HepG2 liver cancer cell line. These findings provide valuable insights for the development of potential anticancer-targeting HCC.
Comparing the effect of internet-delivered short-term progressive muscle relaxation and psychoeducation on mindful ability, visceral hypersensitivity and symptoms of patients with irritable bowel syndrome
Authors: Zargar Fatemeh , Fahim Aliraza , Nikgoftar Niloofar , Tarrahi Mohammad Javed 
Published: August 2023

BACKGROUND:
Irritable bowel syndrome (IBS) is a functional bowel disorder that psychological interventions are effective on it. The present study aimed to compare the effect of internet-delivered short-term PMR (iPMR) and psychoeducation on mindful ability (MA), visceral hypersensitivity (VH), and symptoms of patients with IBS.

MATERIALS AND METHODS:
This randomized clinical trial was performed on individuals with IBS in 2020, recruiting a total of 60 patients fulfilling the inclusion criteria. Prior to the intervention, the Freiburg Questionnaire- Short Form (FMI-SF), the Visceral Sensitivity Questionnaire (VSI), and the Gastrointestinal Symptoms Rating Scale (GSRS) were filled out for the patients. Patients were divided into iPMR and psychoeducation groups randomly. All training in both groups was accomplished via WhatsApp social network. FMI-SF, VSI, and GSRS questionnaires for patients were completed 1 month (post-test) and 2 months later (follow-up). The data was analyzed by SPSS-23 software and one-way analysis of variance (ANOVA).

RESULTS:
Compared to the psychoeducation group, the MA of the iPMR group increased significantly in post-test and follow-up (43.06 ± 7.12 and 42.88 ± 6.28 vs 51.23 ± 11.7 and 56.74 ± 12.36 and P < 0.001) and their VH decreased significantly (37.85 ± 11.6 and 38.03 ± 11.8 vs 26.9 ± 6.45 and 22.46 ± 5.32 and P < 0.001). Also, their GSRS had significant decreases (43.27 ± 10.73 and 41.18 ± 9.31 vs 32.33 ± 8.21 and 25.79 ± 6.30 and P < 0.001).

CONCLUSION:
The findings showed iPMR in patients with IBS, in spite of a few sessions and internet-delivered approach, increased MA and decreased VH and gastrointestinal symptoms of them.
Learning styles and their relationship with preferred teaching methodologies and academic achievement among medical students in teaching medical college, Tamil Nadu
Authors: Muniyapillai Tamilarasan , Kulothungan Karthikeyan , Abdul Malik Shagirunisha Rizvana , Jeevaraj Shekshi Janet , Ashokan Shrimathi , Ravichandran Sindhurajeswari , Ambalavanan Sivaranjani , Jayaraman Sowmiya 
Published: August 2023

BACKGROUND:
Learning styles for medical students have been studied worldwide, and instructors must know and employ the best methods to help students learn. This study evaluates undergraduate medical students' learning styles, preferred teaching methods, and academic examination scores.

MATERIALS AND METHODS:
From January to December 2022, this cross-sectional study was performed with medical students at a teaching hospital in Perambalur, Tamil Nadu, India. About 421 individuals were selected using a probability-proportionate size sampling method. A semi-structured pro forma was used to collect the socio-demographic profile, VARK model learning style questionnaire, and teaching method preferences. The data were analyzed using SPSS-21, and the categorical data were represented as frequency and percentage, whereas mean and standard deviation represent quantitative data. The Chi-square test was used to investigate the relationship between academic performance and teaching approaches to the preferred learning style.

RESULTS:
Kinesthetic learning was the preferred sensory modality. Nearly 61.8% of medical students were female. The most common preferred learning style among them was (36.8%) kinesthetic, followed by (36.1%) auditory. Most of them received good academic results (64.8%), followed by average (21.9%) results. Most of the students had chosen a demonstration (81.2%), followed by an interactive lecture (77.2%), as their preferred teaching method. There is a significant association of learning style with participant age (p 0.007), year of study (p 0.0001), and preferred teaching methodologies like a demonstration, small group discussion, self-presentation, and laboratory work, which is statistically significant. There is no association between learning style and academic performance.

CONCLUSION:
Different teaching approaches, such as demonstration, small-group discussion, self-presentation, and laboratory work, were related to the various learning styles of the students. We also determined that the individuals' preferred learning styles do not affect their academic achievement.
Evaluation of visual pedagogy teaching method for improving oral hygiene practice in children with Autism: An interventional study
Authors: Mahajan Ankit , Anand Santosh , Kriti  , Awinashe Vaibhav , Devanna Raghu , Alessa Noura , Babaji Prashant 
Published: August 2023

BACKGROUND:
Evaluation of visual pedagogy teaching method for improving oral hygiene practice in children with Autism: An interventional study: Visual pedagogy is a relatively newer approach to improve dental care in autistic children. The present study aimed to evaluate visual pedagogy in the practice of oral hygiene in autistic children.

MATERIALS AND METHODS:
This interventional and prospective study was conducted in the Department of Paediatric and Preventive Dentistry. Required approval was obtained from Institutional Ethical Board. Written informed consent was obtained from parents/caregivers. The age range was 5–12 years which included 100 participants (40 males and 60 females). Improvement of oral hygiene was evaluated by recording the tooth brushing technique and ability to follow instructions as presented in the educational video shown on smartphones with Wi-Fi/mobile data. Inclusion criteria: (1) Accessibility and (2) Age range between 5 to 12 years. Exclusion criteria: (1) Non-cooperative children, (2) Children receiving medicines that influence oral health, and (3) Inability to follow-ups. Fones technique was used for brushing teeth in video recording demonstrating it in simple structured steps. Statistical analysis was performed using Chi-square and Independent t tests.

RESULTS:
Statistically significant improvement was observed in oral hygiene (plaque index) after training patients with visual pedagogy.

CONCLUSION:
In the present study, the use of visual pedagogy showed improvement in the oral hygiene scores of autistic children.
Care self-efficacy in adolescents with mental disorders: A qualitative study
Authors: Behzadi Soudabeh , Yektatalab Shahrzad , Momennasab Marzieh , Shaygan Maryam , Zareiyan Armin 
Published: August 2023

BACKGROUND:
The promotion of health in adolescents with mental disorders depends on their levels of self-care empowerment. Self-efficacy is a significant prerequisite for successful self-management and behavior change in adolescents with mental disorders. The present study was conducted to explain the concept of care self-efficacy in adolescents with mental disorders.

MATERIALS AND METHODS:
This qualitative study was carried out using the conventional content analysis approach. Semi-structured interviews (n = 34) were conducted with adolescents having mental disorders, their families, and healthcare providers. The participants were selected from neurology and psychiatry clinics affiliated with University of Medical Sciences using the purposeful sampling method in 2021. Data were analyzed according to Graneheim and Lundman method.

RESULTS:
According to the findings of content analysis, four main themes were derived from the data: “health information-seeking behavior,” “adaptation of life to the disease and treatment conditions,” “adaptive coping,” and “social self-care.”

CONCLUSION:
Based on the findings, the promotion of adaptive styles and social support is effective in acquiring social competencies. As a result, policymakers are suggested to design health-oriented educational programs based on care self-efficacy principles to promote health in adolescents with mental disorders.
The Influence of Organizational Culture and Organizational Commitment on Work Engagement at Pawnshops Sharia Sub-Branch Office in East Bandung Region
Authors: Abidin Mario Aldo Triadi , Ahmad Egi Saepul , Noor Alvath Saemaria 
Published: July 2023

The development of economic problems today, since the enactment of Law Number 10 of 1990, Islamic financial institutions not only consist of banks but also other Islamic financial institutions, namely non-bank financial institutions called sharia pawnshops. One of them is the Sharia Sub-Branch Office Pawnshop in the East Bandung Region which is a non-bank Islamic financial institution that helps the community in the economic sector. Organizational culture and organizational commitment at Pawnshop KCPS East Bandung Region greatly affect work engagement, which is one of the strongest factors of employees in deciding to stay or leave their jobs. The research method used is a quantitative method with an associative approach with primary data types and uses data collection techniques in the form of observations, interviews, literature studies, and questionnaires. Based on the results of the study, the number of employees at the KCPS Pawnshop in the East Bandung Region amounted to 34 people, which had the effect of b culture or organization to k attachment work with test results hypothesis that value tcount (3.797) > ttable (2,03693), there is an effect commitment organization to attachment work with results testing hypothesis that score tcount(15,122) > ttable(2,03693), and there is an effect of culture organization and commitment organization by simultaneous take effect to attachment work with test results Fcount(106,931) > Ftable(3,295).
Immunostimulant Effect Test Of Curcuminoid Extract From Turmeric Rhizome (Curcuma Domestica Val.) In VCO On Rats Induced Cyclophosphamide Againts An Increasing Total Leukocytes And Leukocyte Differential
Authors: Damayanti Damayanti , Yuandani Yuandani , Satria Denny 
Published: July 2023

Turmeric (Curcuma domestica Val.) is a traditional Indonesian plant that has many benefits. Curcuminoids are turmeric compounds known to have effects as immunomodulators and have been proven in several in vivo tests. Immunosuppressive drugs such as cyclophosphamide are widely given to improve clinical symptoms in autoimmune patients and cancer treatment which can cause susceptibility to infection.Therefore,this study aimed to determine the immunostimulating effect of curcuminoid extract from turmeric rhizome on cyclophosphamide-induced white rats. Proof of the immunostimulating effect of curcuminoid extracts was by testing the total leukocytes and leukocytesdifferential. The test results showed that curcuminoid extracts of 1 mL, 0.5 mL, and 0.25 mL increased total leukocytes and leukocyte differential (lymphocytes, neutrophils, monocytes, basophils, eosinophils) with a significant difference (p<0.05) to the Na group CMC 0.5% as a negative control. Therefore, curcuminoid extract had the potential to have an effect as an immunostimulant.
The test results showed that curcuminoid extracts of 1 mL, 0.5 mL, and 0.25 mL increased total leukocytes and leukocyte differential (lymphocytes, neutrophils, monocytes, basophils, eosinophils) with a significant difference (p<0.05) to the Na group CMC 0.5% as a negative control. Therefore, curcuminoid extract had the potential to have an effect as an immunostimulant.
Dukungan Keluarga dan Penerapan Self Care Management Lansia Penderita Hipertensi
Authors: Yulita Meo Maria , Pati Rangga Yohanes Paulus , Ovi Fransiska 
Published: August 2023

Hipertensi merupakan penyebab kematian pertama di dunia. Penanganan hipertensi meliputi terapi farmakologis dan non farmakologis seperti self-care management. Self-care management didefinisikan sebagai kegiatan seseorang dalam mengendalikan gejala, melakukan perawatan fisik dan psikologi ataupun menyesuaikan gaya hidup dengan penyakit yang dialami agar bisa menjaga kesehatan dan kesejahteraan. Tujuan penelitian untuk menganalisis korelasi antara dukungan keluarga dengan penerapan self-care manajemen lansia penderita hipertensi di wilayah kerja Puskesmas Nita. Penelitian ini merupakan penelitian kuantitatif dengan desain analitik korelasi. Teknik sampling yang digunakan Accidental sampling dengan besar sampel sebanyak 65 orang. Angket dipakai sebagai instrumen penelitian. Analisis bivariat menggunakan uji Spearman Rank. Hasil penelitian menunjukan bahwa dukungan keluarga cukup sejumlah 40 orang (61,5%), dukungan keluarga kurang sejumlah 13 orang (20,1%), dan dukungan keluarga baik sejumlah 12 orang (18,4%). Self management baik sejumlah 12 orang (18%), self management cukup sejumlah 7 orang (11%) dan self management kurang sebanyak 46 orang (71%). Hasil uji statistik Spearman Rank menunjukan nilai signifikan p=0,257, sehingga H0 diterima Ha ditolak. Hal ini berarti dukungan keluarga tidak mempunyai hubungan dengan self-care management lansia penderita hipertensi di wilayah kerja Puskesmas Nita.
Pengaruh Pijat Bayi Terhadap Penurunan Kadar Bilirubin
Authors: Desak Putu Kristian Purnamiasih  , Pamenang Ganjar Unggul 
Published: August 2023

Hiperbilirubinemia merupakan peningkatan kadar bilirubin pada bayi baru lahir, terutama pada minggu pertama kehidupan. Hiperbilirubinemia banyak terjadi pada bayi berat lahir < 2500 gram atau bayi yang lahir dari ibu dengan usia kehamilan kurang dari 37 minggu. Penanganan hiperbilirubinemia menggunakan beberapa terapi standar yaitu foto terapi, transfusi tukar atau kombinasi foto terapi dan transfusi tukar. Pijatan yang diberikan pada bayi dapat meningkatkan fungsi pencernaan melalui peningkatan intake nutrisi dan eliminasi yang secara langsung akan membantu mengurangi kadar bilirubin serum bayi. Tujuan penelitian ini adalah untuk mengetahui pengaruh pijat bayi terhadap kadar bilirubin pada bayi yang mengalami hiperbilirubinemia. Metode yang digunakan adalah literature review yang didapatkan dari 11 artikel publikasi diantaranya melalui google scholar, PubMed, dan Science Direct dalam rentang tahun 2019-2021. Hasil dari literature review menunjukkan bahwa pijatan pada seluruh tubuh bayi mempengaruhi motilitas saluran cerna, meningkatkan sirkulasi darah dan aliran limfe serta sirkulasi enterohepatik, meningkatkan jumlah urine sebagai media untuk mengeluarkan bilirubin. Kenyamanan yang diperoleh bayi selama proses pijatan sangat mempengaruhi kadar serotonin pada bayi dan secara tidak langsung mempengaruhi fungsi saluran pencernaan. Peningkatan fungsi saluran pencernaan akan meningkatkan intake nutrisi dan eliminasi dari saluran pencernaan dan perkemihan. Peningkatan fungsi saluran pencernaan yang dibuktikan dengan peningkatan intake nutrisi akan membantu proses konjugasi bilirubin, sedangkan peningkatan defekasi dan eliminasi urine akan membantu mengeluarkan bilirubin terkonjugasi.