bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term outcomes of frontline imatinib therapy for chronic myeloid leukemia in China
Authors: Cheng Fang , Yuan Guolin , Li Qiang , Cui Zheng , Li Weiming 
Published: May 2023

BackgroundImatinib is the first-line therapy recommended for chronic myeloid leukemia (CML) patients in China. We reported a long-term follow-up study of patients on imatinib as first-line treatment for chronic phase (CP) CML to provide an important reference for the actual clinical treatment regimen of CML patients in China.MethodsWe evaluated the long-term efficacy, safety, low-dose attempt after years of treatment, and treatment-free remission (TFR) of 237 CML-CP patients receiving first-line imatinib therapy.ResultsThe median age was 46 years (interquartile range: 33–55). After a median follow-up of 6.5 years, the cumulative complete cytogenetic response, major molecular response (MMR), and MR4.5 rates were 82.6%, 80.4%, and 69.3%, respectively. The 10-year transformation-free, event-free, and failure-free survival rates were 97.3%, 87.2% and 53.5%, respectively. Fifty-two (21.9%) patients with sustained deep molecular response (DMR) were treated with low-dose imatinib after years of imatinib treatment. No significant differences in the 1-year and 2-year molecular relapse-free survival in MMR and MR4 were observed between the standard-dose and low-dose groups. Twenty-eight (11.8%) patients discontinued imatinib, and the median time to maintain DMR before discontinuation was 8.43 years. Thirteen patients (5.5%) remained in TFR for a median of 43.33 months. No patients transformed to accelerate or blast phase or died. No new, late toxicity was observed, and the most frequent grade 3/4 adverse events were neutropenia (9.3%), anemia (7.6%), thrombocytopenia (6.3%), and rash (4.2%).ConclusionThis study confirmed the long-term efficacy and safety of imatinib for treating Chinese CML patients. Additionally, it demonstrated the feasibility of imatinib dose reduction and TFR attempts in patients with sustained stable DMR after years of imatinib treatment in real-life settings.
Examining mental health knowledge, stigma, and service use intentions among Royal Canadian Mounted Police cadets
Authors: Andrews Katie L. , Jamshidi Laleh , Shields Robyn E. , Teckchandani Taylor A. , Afifi Tracie O. , Fletcher Amber J. , Sauer-Zavala Shannon , Brunet Alain , Krätzig Gregory P. , Carleton R. Nicholas 
Published: May 2023

BackgroundRoyal Canadian Mounted Police (RCMP) officers experience an elevated risk for mental health disorders due to inherent work-related exposures to potentially psychologically traumatic events and occupational stressors. RCMP officers also report high levels of stigma and low levels of intentions to seek mental health services. In contrast, very little is known about the levels of mental health knowledge and stigma of RCMP cadets starting the Cadet Training Program (CTP). The current study was designed to: (1) obtain baseline levels of mental health knowledge, stigma against peers in the workplace, and service use intentions in RCMP cadets; (2) determine the relationship among mental health knowledge, stigma against peers in the workplace, and service use intentions among RCMP cadets; (3) examine differences across sociodemographic characteristics; and (4) compare cadets to a sample of previously surveyed serving RCMP.MethodsParticipants were RCMP cadets (n = 772) starting the 26-week CTP. Cadets completed questionnaires assessing mental health knowledge, stigma against coworkers with mental health challenges, and mental health service use intentions.ResultsRCMP cadets reported statistically significantly lower levels of mental health knowledge (d = 0.233) and stigma (d = 0.127), and higher service use intentions (d = 0.148) than serving RCMP (all ps &lt; 0.001). Female cadets reported statistically significantly higher scores on mental health knowledge and service use and lower scores on stigma compared to male cadets. Mental health knowledge and service use intentions were statistically significantly positively associated. For the total sample, stigma was inversely statistically significantly associated with mental health knowledge and service use intentions.ConclusionThe current results indicate that higher levels of mental health knowledge were associated with lower stigma and higher intention to use professional mental health services. Differences between cadets and serving RCMP highlight the need for regular ongoing training starting from the CTP, designed to reduce stigma and increase mental health knowledge. Differences between male and female cadets suggest differential barriers to help-seeking behaviors. The current results provide a baseline to monitor cadet mental health knowledge and service use intentions and stigma as they progress throughout their careers.
Association of adolescent self-esteem in 2014 and cognitive performance in 2014, 2016, and 2018: a longitudinal study
Authors: Wang Xue , Liu Yu , Zhao Zhe , Liu Wenting , Chen Yuqi , Chen Yu , Zang Shuang 
Published: May 2023

BackgroundCognition has long been regarded as a significant factor influencing individuals’ lives. Prior studies have underscored that self-esteem is associated with cognition, and there exists a knowledge gap regarding whether self-esteem remains associated with subsequent cognitive performance during adolescence, a crucial period for neurological development and influencing adult outcomes.MethodsWe conducted this population-based study using longitudinal data stretching three waves (2014, 2016, and 2018) of surveys from the nationally representative China Family Panel Studies (CFPS) to explore the association between adolescents’ self-esteem in 2014 and cognitive performance in 2014, 2016, and 2018.ResultsThe results of the present study showed that self-esteem during adolescence in 2014 was significantly associated with cognitive performance in 2014, 2016, and 2018. This association remained robust after an extensive range of covariate adjustments (e.g., adolescents, parental, and family characteristics).ConclusionThe findings in this study provide further insight into the understanding of the related factors for cognitive development across the life course and highlight the importance of improving individual self-esteem during adolescence.
Electronic nose based on multiple electrospinning nanofibers sensor array and application in gas classification
Authors: Zang Chuanlai , Zhou Haolong , Ma Kaijie , Yano Yasuo , Li Shuowei , Yamahara Hiroyasu , Seki Munetoshi , Iizuka Tetsuya , Tabata Hitoshi 
Published: May 2023

To mimic the human olfactory system, an electronic nose (E-nose, also known as artificial olfactory) has been proposed based on a multiple gas sensor array and a pattern recognition algorithm. Detection of volatile organic components (VOCs) has many potential applications in breath analysis, food quality estimation, and indoor and outdoor air quality monitoring, etc. In this study, a facile single-needle electrospinning technology was applied to develop the four different semiconductor metal oxide (MOS) nanofibers sensor arrays (SnO2, CuO, In2O3 and ZnO, respectively). The array shows a smooth surface and constant diameter of nanofiber (average of 150 nm) resulting in high sensitivity to multiple target analyte gases. Five human health related VOCs gases were measured by fabricated E-nose and different response patterns were obtained from four MOS nanofibers sensors. Combined with feature extraction from the response curves, a principal component analysis (PCA) algorithm was applied to reduce the dimension of feature matrix, Thus, the fabricated E-nose system successfully discriminated five different VOCs gases. Real-time and non-invasive gas monitoring by E-nose is very promising for application in human health monitoring, food monitoring, and other fields.
New Records of the Copidognathus gibbus Group (Acari, Halacaridae) from Korea, with Descriptions of C. levicostatus n. sp. and C. vicinus
Authors: Lee Jimin , Shin Jong Hak , Chang Cheon Young 
Published: May 2023

Two marine halacarids, Copidognathus levicostatus n. sp. and C. vicinus Bartsch, 1997, belonging to the C. gibbus group, have been recorded based on both sexes from the microhabitat of intertidal and sublittoral rocks on the coast of South Korea. Copidognathus levicostatus n. sp. Is characterized by a combination of features, as follows: the absence of areolae with rosette pores on all dorsal and ventral plates, the presence of a short frontal process, a pair of costae with raised narrow ribs on the posterior dorsal plate, the partial fusion of the anterior epimeral plate and genitoanal plate in both sexes, and three pairs of perigenital setae in the male. The Korean specimens of C. vicinus Bartsch, 1997 agree well with the original description from Hong Kong, except for the lateral claws bearing a comb. This study provides detailed (re)descriptions of the morphological characteristics of the two Korean halacarid species, C. levicostatus n. sp. and C. vicinus, based on illustrations and scanning electron microscope photomicrographs. Additionally, we present a dichotomous key for known Copidognathus species in Korean waters, accompanied by a brief comment on their occurrence in various microhabitats, especially their habitat preferences for geniculate and non-geniculate red coralline algae.
Multi-frequency composite pulse sequences for sensitivity enhancement in hexagonal boron nitride quantum sensor
Authors: Gu Hao , Nakamura Yuki , Sasaki Kento , Kobayashi Kensuke 
Published: May 2023

Abstract
A negatively charged boron vacancy (

V

B

−

) in hexagonal boron nitride (hBN) has recently started to be used as a magnetic sensor. However,

V

B

−

has magnetic resonance spectra broadened by hyperfine interactions, which decreases the signal contrast and thus degrades the magnetic field sensitivity. Here we propose multi-frequency composite pulse sequences to enhance the contrast of the measurement signal in the Rabi oscillation. We demonstrate that the sequence using five microwave frequencies enhances the signal contrast, improving the sensitivity by a factor of 2.3 compared to the conventional sequence.
معالجة الممثل للشخصية في مسرح )بريخت( الملحمي " مسرحية الإنسان الطيب أنموذجاً "
Authors: د. مظفر كاظم محمد  
Published: May 2023

تتعرّض مشكلة هذا البحث إلى كيفية معالجة الممثل العراقي للشخصية الدرامية في

مسرح ( بريخت ) الملحمي ؛ وخصوصا تلك التي في مسرحية ( الإنسان الطيب من
ستزوان ) ؛ وهل تتطابق المعالجة مع طروحات ( بريخت ) بشأن عدم التقمص من قبل
الممثل 0 والوقوف خارج الشخصية ؛ وأبعاد المتفرج عن التطابق أو التعاطف مع
الشخصية ؛ بل والنظر أليها بنظرة ناقدة.

ويهدف البحث إلى تعرف طروحات ( بريخت ) عن كيفية معالجة الممثل للشخصية
الدرامية ؛ ومقاربة الممثل العراقي من تلك الكيفية ؛ وذلك بخصوص شخصيات مسرحية
( الإنسان الطيب من ستزوان ) التي اخرجها ( عوني كرومي ) لفرقتي المسرح الفني
الحديث والمسرح الشعبي.

في المبحث الأول من الإطار النظري للبحث يتطرق الباحث إلى ماهية ( الشخصية )
عموماً وماهية (الشخصية الدرامية) بالأخص ويناقش أراء علماء النفس بهذا الخصوص؛
وفي مقدمتهم (فرويد) . وفي المبحث الثاني يناقش الباحث طروحات (برتولت بريخت)
حول مسرحه الملحمي ؛ وحول شخصياته الدرامية ؛ والأسس التي أعتمدها في بناء
الشخصية ؛ ومعالجة الممثل لها ؛ إذ يكون الممثل أشبه ما يكون بالراوية للشخصية ولا
يتصف بصفات خاصة بها . ويرفض ( بريخت ) العلبة السايكلوجية الخاصة بالشخصية .
أي أن على الممثل أن لا يتبنى أفعال الشخصية ؛ بل يفسح المجال للمتفر ج أن يبحث عن
البدائل . وأن الشخصية لا تمثل فرداً في المجتمع ؛ بل تمثل فئة أو هيئة إجتماعية معينة.
Synthesis and Characterization of Some New Heterocyclic Compounds Via Unsaturated Ketone with Evaluating of Their biological Activity
Authors: M. T. Tawfiq  
Published: May 2023

This work includes preparing of some new derivatives of pyrimidine ,
pyrazole , and isoxazole from the reaction between

benzylideneacetophenone (chalcone) (1) and hydrazine derivatives in the
presence of sodium acetate and dry acetone to obtain heterocyclic
compounds (2-6).

Reaction of (2) with different substituted benzaldehydes in absolute
ethanol and drops of glacial acetic acid gave Schiff bases derivatives (8-
10) respectively. Schiff bases (8-10) were reacted with sodium azide in
THF to give tetrazole derivatives (11-13). Reaction of (2) with sodium
nitrate and concentrated hydrochloric acid , then with phenol gave diazo
compound (7).

The prepared compounds were diagnosed mediated FT.IR,'H-
NMR,UV/Vis spectra, melting points were recorded and the purity was
checked through TLC technique. The biological effectiveness were
measured for some prepared compounds.
POTENSI EKSTRAK METANOL DAUN KIRINYUH (Chromolaena odorata (L). R.M.King & H.Rob.) SEBAGAI ZAT AKTIF UNTUK SABUN CUCI TANGAN
Authors: Tuslinah Lilis 
Published: May 2023

ABSTRACT The methanol extract of kirinyuh leaves (Chromolaena odorata (L). R.M.King & H.Rob.) is able to inhibit the growth of gram-positive Staphylococcus aureus so that it has potential as an active substance for hand washing soap. In this study, liquid hand washing soap was made with a concentration of 0.01% kirinyuh leaf extract using a soap base using a gelling agent Carbopol. The optimum concentration of Carbopol with a viscosity of 2217 cPs is 0.6%. The liquid soap preparation was analyzed including viscosity 2217 cPs, pH 6.38, total active ingredient 18.62% mass fraction, insoluble material in ethanol 0.11% mass fraction, free fatty acids 0.63% mass fraction, phenol coefficient 1, Total Plate Number 4,535 g/colony. In the hedonic test, the highest panelist response was found in the purple color of the wine aroma and the yellow color of the lemon aroma Keywords: Liquid Hand Washing Soap, Phenol Coefficient, Kirinyuh Leaves. ABSTRAK Ekstrak metanol daun kirinyuh (Chromolaena odorata) mampu menghambat pertumbuhan bakteri gram positif Staphylococcus aureus sehingga mempunyai potensi sebagai zat aktif sabun cuci tangan Pada penelitian ini dibuat sabun cair cuci tangan dengan konsentrasi ekstrak daun kirinyuh 0,01% menggunakan basis sabun menggunakan gelling agent Carbopol. Konsentrasi optimum Carbopol dengan viskositas 2217 cPs adalah 0,6 %. Sediaan sabun cucu cair dilakukan analisis meliputi viskosita 2217 cPs, pH 6,38, Total bahan aktif 18,62 % fraksi massa, Bahan tidak larut dalam etanol 0,11% fraksi massa, Asam lemak bebas 0,63% fraksi massa, Koefisien fenol 1, Angka Lempeng Total 4.535 g/koloni. Pada Uji hedonik respon panelis tertinggi terdapat pada warna ungu aroma anggur dan warna kuning aroma lemon. Kata kunci: Sabun Cair Cuci Tangan, Koefisien fenol, Daun Kirinyuh
KADAR FLAVONOID TOTAL BEBERAPA TUMBUHAN FAMILI ASTERACEAE
Authors: Hidayah Himyatul 
Published: May 2023

<p align="center"><strong><em>ABSTRACT</em></strong></p><p><em>Indonesia is a country with abundant biological wealth which has 25% of plant species in the world which reaches 20,000 species that are useful in medicine. Plants of the Asteraceae family are often used by the community as traditional medicine. The pharmacological effects of Asteraceae plants can be attributed to various phytochemical compounds, including polyphenols, phenolic acids, flavonoids, acetylene and triterpenes. Flavonoids have been shown to have high activity for inhibiting xanthine oxidase. The aim of this study was to determine the total flavonoid content of several members of the Aseteraceae family (Taraxacum officinale, Crassocephalum crepidioides, Elephantopus scaber, Gynura procumbens, Ageratum conyzoides, Sonchus arvensis) using UV-Visspectrophotometry. The results showed that all Asteraceae family plants tested positive for flavonoid compounds. Determination of total flavonoid levels was carried out based on the AlCl3 method with total flavonoids expressed in QE (Quercetin equivalent) at a maximum wavelength of 415 nm. The results showed that the average content of total flavonoids of Crassocephalum crepidioides 3.4345% ± 0.2706, Taraxacum officinale 2.3217% ± 0.032, Ageratum conyzoides, L 3.3764% ± 0.257, Sonchus arvencis L. 2.7279% ± 0.0399, Gynura procumbens 2 .2825% ± 0.1370, and Elephantopus scaber 2.5294% ± 0.0861. The conclusion of this study was that the highest total flavonoid content was in Crassocephalum crepidioides and Gynura procumbens plants with the lowest total flavonoid content.</em></p><p><em> </em></p><p><em>Keywords: Phytochemical Screening, Total Flavonoid, Family Asteraceae</em></p>
PENGARUH KUALITAS PELAYANAN KEFARMASIAN TERHADAP KEPUASAN PASIEN RAWAT JALAN DI RUMAH SAKIT UMUM DAERAH SUMEDANG TAHUN 2022
Authors: Kunaedi Aan 
Published: May 2023

Patient satisfaction is the level of patient feelings that arise as a result of the performance of health services obtained after the patient compares with what is felt. Pharmaceutical services that started from drug oriented to patient-oriented with a philosophy of pharmaceutical care (pharmaceutical care), make pharmacists required to provide quality pharmaceutical services this will affect the satisfaction of services received by patients. The problems in the outpatient pharmacy installation at Sumedang Hospital include infrastructure, namely the waiting room is not spacious enough, the availability of drugs, and complaints related to waiting time for drugs. The purpose of this study was to determine the satisfaction of outpatients with the quality of pharmaceutical services and the influence between the quality of pharmaceutical services and satisfaction of outpatients at the pharmaceutical installation of Sumedang Hospital in 2022. Correlation quantitative research with cross-sectional research design. Data collection using questionnaires and interviews with samples taken from as many as 120 respondents with the purposive sampling technique. Assessment of patient satisfaction is measured based on service quality using the Servqual model method with a Likert scale. The statistical test used is the sperm rank test. The results showed that the quality of pharmaceutical services was very good with an average index of 80%, and patient satisfaction was very satisfactory with an average index of 83%. The results of the Spearman rank test show that there is a correlation between the quality of pharmaceutical services and patient satisfaction with an average correlation coefficient of 0.60-1,000, which means that it has a strong correlation.
Analisis Manajemen Pengelolaan Badan Usaha Milik Desa Tonti Daeng Manggangka Di Desa Palangka, Kabupaten Sinjai
Authors: Asriani Asriani , Miswar Muhammad Dedy 
Published: May 2023

Tujuan penelitian ini untuk mengetahui manajemen tingkat perencanaan pengorganisasian pelaksanaan, dan pengawasan pengelolaan Badan Usaha Milik Desa (BUMDes) Tonti Daeng Maggangka di Desa Palangka. Penelitian ini dilaksanakan dikantor BUMDes Desa Palangka Kecamatan Sinjai Selatan Kabupaten Sinjai dengan menggunakan sampel sebanyak 62 orang, alasan pemilihan BUMDes Desa Palangka karena desa ini merupakan salah satu daerah yang memiliki BUMDes serta telah terjadi pengembangan ekonomi masyarakat desa di desa Palangka Kecamatan Sinjai Selatan Kabupaten Sinjai dengan adanya BUMDes. Dari hasil perhitungan menggunakan metode analisis regresi liner berganda melalui program SPSS untuk menentukan atau melihat pengaruh variabel Secara Simultan atau parsial, bahwa Planning, X1 = 3,902; Organizing X2 = 2,772. Implementation X3 = 2,350, Controling X4 = 1,274 mempunyai pengaruh yang simultan terhadap manajemen BUMDes (Y). Dari keempat manajemen tersebut, yang paling dominan pengaruhnya adalah Planning, X1 = 3,902.The purpose of this study was to determine the management level of planning, organizing, implementing, and supervising the management of Tonti Daeng Maggangka Village Owned Enterprises (BUMDes) in Palangka Village. This research was carried out at the BUMDes office in Palangka Village, South Sinjai District, Sinjai Regency using a sample of 62 people, the reason for choosing BUMDes in Palangka Village is because this village is one of the areas that has BUMDes and there has been economic development of rural communities in Palangka Village, South Sinjai District, Sinjai Regency. the existence of BUMDes. From the results of calculations using the method of multiple linear regression analysis through the SPSS program to determine or see the effect of variables Simultaneously or partially, that Planning, X1 = 3.902; Organizing X2 = 2,772. Implementation X3 = 2.350, Controling X4 = 1.274 has a simultaneous effect on BUMDes management (Y). Of the four managements, the most dominant influence is Planning, X1 = 3.902.
Performance Analysis of Load Balancing Learning Management System Moodle on Docker Container
Authors: Setyaji Bayu , Pranata Mega , Kresna Iqsahiro 
Published: May 2023

Permintaan yang berlebih pada web server menyebabkan server tidak mampu melayani permintaan yang mengakibatkan overload dan menyebabkan server down. Load balancing dapat menjadi solusi, dengan kemampuan membagi beban kerja ke beberapa server secara seimbang. Metode load balancing dapat diterapkan pada teknologi container. Docker merupakan salah satu teknologi container yang berfungsi menjalankan aplikasi dengan cepat dan terisolasi didalam sebuah wadah yang disebut container. Penelitian ini ditujukan untuk mengukur performa dari metode load balancing untuk server learning management system dengan dua algoritma yaitu least connection dan round robin yang diterapkan dalam container docker. Pengujian dilakukan dengan memberikan request pada server dengan tiga variasi yaitu 1000 , 2000 dan 4000 request . Hasil pengujian mendapatkan hasil bahwa algoritma least connection mendapatkan hasil yang lebih baik pada pengujian dengan request 1000 dan 2000 dengan nilai throughput tertinggi adalah 4,08333 Mbps. Kemudian nilai reponse time algoritma least connection unggul pada pnegujian ke 1000 dan 2000 sedangkan round robin unggul pada request 4000 dengan nilai 4985,31 ms. Lalu pada pengujian nilai error algoritma least connection memiliki nilai error lebih rendah pada semua skema pengujian dan pada penggunaan cpu.
Portée et limites des outils d’enseignement à distance utilisés par les enseignants de quatre écoles marocaines en contexte pandémique
Authors: Benrherbal Abderrahmane , Rioux Miranda 
Published: May 2023

L’ensemble des acteurs du milieu éducatif restent préoccupés par l’inégalité scolaire entre les zones rurales et les zones urbaines. Avec la crise sanitaire due à la pandémie de la COVID-19, la situation est devenue encore plus préoccupante. Malgré les craintes soulevées, on ne dispose toujours pas d’un répertoire exhaustif des diverses pratiques d’enseignement à distance utilisées en zones rurales. Notre approche méthodologique s'inscrit dans un paradigme interprétatif qualitatif dans une perspective collaborative (Desgagné et coll.,2001) de cosituation, de coopération et de coproduction. Cette présentation passe en revue et évalue les pratiques d’enseignement à distance utilisées en milieu rural au Maroc pour l’enseignement primaire dans le cadre de la continuité pédagogique.
Notre travail permet en effet d’identifier cinq outils d’enseignement à distance : « WhatsApp », Plateforme « Telmidtice », « Facebook », télévision puis distribution des livres scolaire. Les résultats des travaux de groupe dans les quatre écoles étudiées, ainsi que les discussions en plénière, montrent cependant qu’après la fermeture des écoles, il y a eu une période de tâtonnement entre les cinq outils d’enseignement à distance. Par la suite, l’utilisation de l’application « WhatsApp » a fait l’unanimité malgré les contraintes de cet outil. Cette évaluation nous permet d’envisager des perspectives d’amélioration des systèmes d’enseignement.