bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple sclerosis and COVID-19: A retrospective study in Iran
Authors: Sedighi Behnaz , Haghdoost Aliakbar , Jangipour Afshar Parya , Abna Zohre , Bahmani Shamimeh , Jafari Simin 
Published: March 2023

Objectives
Previous studies suggested a higher rate of COVID-19 infection in patients with multiple sclerosis than in the general population, and limited studies addressed the impact of COVID-19 and its vaccination in patients with multiple sclerosis in Iran. We decided to investigate the factors associated with COVID-19 infection, the effects and side effects of the COVID-19 vaccination in patients with multiple sclerosis (MS).

Methods
We used the data of the patients with multiple sclerosis registered in a referral clinic in Kerman, one of the large cities in Iran (a population of 537,000 inhabitants), to explore the association between demographic variables, the history of COVID-19 vaccination, and the clinical outcomes.

Results
Of the 367 participants in this study, 88.3% received the COVID-19 vaccine, 35.4% were confirmed COVID-19 cases, and the incidence of COVID-19 was much higher before vaccination (24.5% before vaccination versus 10.1% after vaccination). The multivariable logistic regression model showed that male gender (OR = 2.64, 95% confidence interval: 1.21, 5.74) and current employment (OR = 3.04, 95% confidence interval: 1.59, 5.80) were associated with an increased risk of COVID-19. The only factor associated with the adverse effects of COVID-19 vaccination was the type of vaccine (AstraZeneca).

Conclusion
Our findings showed that the vaccination protected MS cases considerably against COVID-19. In addition, the side effects of the vaccines were not noticeably high in these cases as well. Among all COVID-19 vaccines, AstraZeneca had the most common side effects, so people must be aware of them before vaccination. The male gender and employment were the most important variables in the prevalence of COVID-19 in patients with multiple sclerosis in our study.
VITAMIN C, VITAMIN D DAN IMUNITAS PASIEN COVID-19
Authors: Aisy Saskia Rohadatul , Rizal Ahmad , Simanjuntak Betty Yosephin 
Published: March 2023

Latar belakang: Pada tahun 2020 wabah Virus Corona (Covid-19) menyebar hampir di seluruh Negara. Cara untuk mengatasi Covid-19 yaitu dengan peran vitamin C dan D. Vitamin C memiliki sifat antioksidan yang mampu melindungi sel dan jaringan tubuh dari kerusakan oksidatif. Sedangkan vitamin D berperan meningkatkan innate imunity yang akan menghambat aktivitas bakteri Covid-19.Tujuan: Penlitian ini bertujuan untuk mengkaji artikel tentang suplementasi vitamin C dan vitamin D terhadap imunitas pasien covid-19.Metode: Penelitian ini menggunakan kajian (ulasan) literatur pada 10 artikel dengan menggunakan database Google Scholar, Pubmed dan Science Direct terbitan tahun 2019-2021. Studi ini diawali penyeleksian artikel dengan diagram Preferred Reporting Item for Systematic and Meta-analysis (PRISMA). Kriteria yang digunakan adalah artikel yang diakses secara penuh ( full text) dalam format pdf menggunakan bahasa Inggris dengan kata kunci vitamin C, vitamin D dan Covid-19.Hasil: Literatur review ini menunjukkan bahwa dari 10 artikel yang terdiri masing-masing 5 artikel tentang vitamin C dan vitamin D. Pemberian suplementasi vitamin C dapat mengurangi gejala, meningkatkan kesadaran dan menurunkan risiko kematian akibat Covid-19. Suplementasi vitamin D berpengaruh terhadap lama hari rawat di rumah sakit, kebutuhan oksigen dan peningkatan serum 25(OH)D sehingga dapat mempercepat penyembuhan Covid-19.Simpulan: Vitamin C berpengaruh dalam meningkatkan sistem imun dan berfungsi sebagai antioksidan. Vitamin D dapat berpengaruh dalam meningkatkan sistem imun bawaan dan sistem imun adaptif, sehingga dapat mempercepat penyembuhan infeksi Covid-19.
Mappa mundi w kodeksie Jakuba z Kowalewic (BUP Rkp. 1746) a Historia Brittonum Nenniusza
Authors: Nowak Łukasz 
Published: March 2023

Niniejszy artykuł stanowi analizę treściową mappae mundi zawartej w kodeksie Jakuba z Kowalewic (BUP Rkp. 1746), próbę odpowiedzi na pytania o proweniencję wpisanego w nią tekstu i jej autora oraz orientacyjne określenie czasu jej powstania. Ponadto poddano analizie listy prowincji wpisane zarówno w mapy typu T-O, jak i te zmieszczone poza nimi, w zebranych kodeksach zawierających analogiczny tekst do tego z poznańskiego kodeksu, pochodzący pierwotnie z IX-wiecznego dzieła autorstwa Nenniusza pt. Historia Brittonum. Artykuł prezentuje wyniki poszukiwania w polskich zbiorach map typu T-O, które mogły być wzorem dla mapy znajdującej się w kodeksie Jakuba z Kowalewic. Podjęto również próbę analizy treściowej listy prowincji wpisanej w mapę oraz wskazania różnic i cech wspólnych w znalezionych mapach i egzemplarzu w kodeksie Rkp. 1746.
The Menaechmi
Authors: Zhmud Leonid 
Published: March 2023

Abstract
In the mid-first century BC Geminus of Rhodes, a scientist and philosopher close to Posidonius, composed a comprehensive Theory of Mathematical Sciences, in the surviving fragments of which the numerous characters are referred to plainly by name, with some of them being namesakes of other, more well-known mathematicians and philosophers. This paper tries to set apart the namesakes of Geminus, of which there are four in his fragments: Theodorus, Hippias, Oenopides, and Menaechmus.
Fuzzy induced controller for optimal power quality improvement with PVA connected UPQC
Authors: Simhachalam Ravada , Goswami Agam Das 
Published: March 2023

Abstract
The major power quality issues in grid are voltage fluctuations and harmonics. For better power quality of the power system during disturbances on the grid, the UPQC device is utilized to maintain voltage magnitude and reduced harmonics. At the DC link of UPQC along with the capacitor, a renewable PV source is connected which contributes in voltage compensation by the series VSC and harmonics compensation by the shunt VSC. For stable DC voltage generation from PV source a modified P&O MPPT with DC reference is included controlling the boost converter connected to PV source. The controllers of VSCs are operated by feedback loop synchronized schematics with voltage reference generation in series VSC control and current reference generation in shunt VSC control. The shunt control is updated with hybrid Fuzzy-PI controller replacing the traditional PI controller further improving the power quality of the grid. The hybrid Fuzzy-PI varies the K

p
and K

i
gains as per the error generated by the DC voltage comparison concerning 25 rule-base for each gain. A comparative performance analysis is done with both the controllers in the shunt converter and the results are generated using MATLAB Simulink software.
Importance of moderate-to-vigorous physical activity during the COVID-19 pandemic: a systematic review and meta-analysis
Authors: Rejeki Purwo Sri , Witarto Bendix Samarta , Witarto Andro Pramana , Rifdah Salsabila Nabilah , Wafa Ifan Ali , Utami Dita Mega , Izzatunnisa Nabilah , Kencono Wungu Citrawati Dyah , Khaerunnisa Siti , Sakina  , Fazleen Mohd Fathil Nur Ezza 
Published: March 2023

Abstract
Moderate-to-vigorous physical activity (MVPA) has been shown to have a favorable effect on many diseases as a complementary therapy and is a critical component of healthy living. During the pandemic era, physical activity has been promoted for resistance against coronavirus disease 2019 (COVID-19). However, there is scarce evidence on whether MVPA could reduce the infectivity and susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The objective of this meta-analysis was to determine the effect of MVPA on morbidity, mortality, and duration of hospitalization in COVID-19 patients. We performed a comprehensive search of five online databases for eligible studies up to September 9, 2021. Meta-analyses were conducted to determine the association between MVPA and COVID-19-related morbidity, hospitalization, and mortality. The odds ratio (OR) was applied as the summary statistic for the primary outcomes. Secondary analyses were conducted to evaluate the difference in the metabolic equivalent of tasks (METs) between the outcome and non-outcome groups with the mean difference as the pooled effect. This meta-analysis included eight observational studies. We found that MVPA significantly reduced the odds of contracting SARS-CoV-2 infection (OR=0.88; 95% confidence interval [CI] = 0.85–0.92), hospitalization (OR=0.56; 95% CI=0.35–0.92), and mortality (OR=0.42; 95% CI=0.21–0.81) due to COVID-19 compared to no physical activity. METs≥500 min/week were linked to decreased morbidity and mortality of COVID-19 (OR=0.94 [95% CI=0.90–0.98]; OR=0.56 [95% CI=0.38–0.83]). COVID-19 patients with MVPA demonstrated a lower risk of COVID-19-related morbidity, hospitalization, and mortality compared to those who were less active, highlighting the importance of an active lifestyle despite the pandemic situation where such activities are limited.
Clinical profile of Laron dwarfism – experience from a tertiary care institute in Chennai
Authors: Sethuraman Chidambaram , Venkatasamy Seenivasan 
Published: March 2023

Abstract

Objectives
Laron dwarfism is a rare genetic disorder first reported among Israeli jewish children, subsequently about 350 cases cases have been reported worldwide. We aim to describe the clinical profile of nine children with Laron dwarfism from Institute of Child Health, Chennai.

Methods
Analysis of case records from 2010 to 2018.

Results
Male:female ratio is 6:3. Mean age of the children at the time of diagnosis was 3 years. All children were extremely short, and mean height Z score (SD) was −7.7(0.8). All children had characteristic facies with no hypoglycaemic episodes. Microcephaly was present in four children out of which two had developmental delay. Three out of six boys had micropenis. All children had low insulin like growth factor-1 (IGF-1) and high basal growth hormone (GH) with a mean (SD) of 39.6 (11.2) ng/mL.

Conclusions
Suspicion of Laron syndrome should be high when child presents with features of Growth Hormone Deficiency (GHD) with extreme stunting.
The crystal structure of 5,10-bis(2-methoxyethyl)-5,10-dihydro-[1,2,3,4]tetrathiocino[5,6-b:8, 7-b′]diindole, C22H22N2O2S4
Authors: Ni Ming , Ni Penghui 
Published: March 2023

Abstract
C22H22N2O2S4, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 8.4865(14) Å, b = 11.756(2) Å, c = 12.863(2) Å, α = 69.693(2)°, β = 70.812(2)°, γ = 72.170(2)°, V = 1109.6(3) Å3, Z = 2, Rgt
(F) = 0.0280, wRref
(F
2) = 0.0753, T = 296(2) K.
Extreme hyperferritinemia in restrictive type anorexia nervosa
Authors: Amanoal Christine Hvolby , Nielsen Lene Kongsgaard , Thomsen Henrik Holm 
Published: March 2023

Summary
Iron metabolism and markers hereof are altered in anorexia nervosa (AN) but far from completely understood. We report a case of extreme hyperferritinemia in a patient with AN and discuss the possible mechanisms and current knowledge about the association between hyperferritinemia and AN. A 20-year-old woman with a history of AN presented with bradycardia, weariness, and malaise in addition to an incidentally very high ferritin level. The symptoms disappeared spontaneously after a short admission. There were no signs suggestive of systemic, hematological, or malignant disease causing the very high concentration of ferritin. Her body weight was in decline, leading up to admission, but did initially increase after discharge accompanied by declining ferritin concentration. However, a clear association between ferritin dynamics and weight changes or physical activity was not identified and neither were other causes of the hyperferritinemia. Around one in four patients with AN have increased ferritin concentrations. Our case represents the highest ferritin concentration reported in a patient with AN without other underlying causes or comorbidities.

Learning points

Perturbed iron metabolism is frequent in restrictive type anorexia nervosa but incompletely understood.

Altered ferritin in anorexia nervosa may be linked to nutritional status.
Determination of pancratistatin in mouse blood by ultra-liquid chromatography-tandem quadrupole mass spectrometry and its application
Authors: Zhang Aiguo , Zhang Hanqi , Wang Xianqin , Chen Shuangqian , Jin Yongxi 
Published: March 2023

AbstractIn this study, a UPLC-MS/MS method was developed for determination of pancratistatin in the mouse blood, and the pharmacokinetics of pancratistatin in mice after intravenous (5 mg kg−1) and intragastric (15 mg kg−1) administration was studied. HSS T3 column was used for separation with mobile phases of acetonitrile and 0.1% formic acid using gradient elution procedure. The blood sample was treated by protein precipitant with acetonitrile, midazolam was used as internal standard (IS). Multiple reaction monitoring mode (MRM) was used for quantitative analysis, m/z 326.2→83.8 for pancratistatin and m/z 326.2→291.4 for IS in electrospray (ESI) positive interface. It showed a good linear in the range of 10–4,000 ng mL−1 (r > 0.998); the intra-day and inter-day precision was <15%, and the accuracy was 93%–105%. The recovery was better than 82%, and the matrix effect was 94%–105%. The developed UPLC-MS/MS method was fast, selective, and suitable for the pharmacokinetics of pancratistatin in mice.
What should urologist know about sperm DNA fragmentation
Authors: Olefir Yu. V. , Efremov E. A. , Rodionov M. A. , Zhuvilko A. R. , Popov D. M. , Monakov D. M. 
Published: March 2023

Background. Spermogram remains one of the main laboratory methods of male infertility diagnosis, but normal spermogram do not guarantee the patient’s fertility. More over, it does not allow us to find out the cause of infertility in 10–30 % cases. The sperm DNA fragmentation (SDF) studying is a possible solution to this problem.Aim. To systematize the currently available information about of clinical significance, causes, methods of diagnosis and treatment of SDF to be used by an urologist in rutine practice.Materials and methods. The search of publications in databases was carried out eLIBRARY and PubMed using the keywords: male infertility, sperm DNA fragmentation, etiology, causes, varicocele, oxidative stress, diagnostics, treatment. 111 studies were selected, which are included in this review.Results. Alcohol, tabacco smoking, narcotic substances, psychoemotional stress, adverse environmental factors and occupational intoxications, reproductive system infections and inflammation, varicocele and older paternal age can lead to SDF increasing and unfavorable reproductive outcomes, for natural pregnancy and while use an assisted reproductive technologies. The data on the role of metabolic syndrome in the genesis of SDF are equivocal. The oxidative stress is the main mechanism of sperm DNA damage. The SDF level can be estimated using direct (Comet, TUNEL) and indirect (SDS, SCSA) methods. Treatment of SDF is aimed at eliminating the detrimental factors, combating oxidative stress and recombinant follicle-stimulating hormone use.Conclusion. The level of SDF is an important indicator for assessing male reproductive potential and predicting the success of various methods of overcoming infertility. Recently, there has been an expansion of indications for the use of methods for assessing the integrity of sperm genetic material in the clinical practice of specialists in the field of reproductive medicine.
Fermentation Effect of Cacao Beans Originate from Jember on Polyphenol-Flavonoid Content and Radical Scavenging Activity
Authors: Agustriana Eva , Valentino Herly Angga , Rahmani Nanik , Nuryati Nuryati , Firmanto Hendy , Rachmayati Rike , Yulianti Siti Eka , Nuryana Isa , Yopi Yopi , Lisdiyanti Puspita 
Published: March 2023

Cacao is attractive for its flavor and taste and its beneficial effects. Therefore, this commodity is promising to be developed as a functional food. Many studies reported the bioactive compounds in cacao beans and their health benefits. However, to attain desirable flavor and taste, the curing process of cacao beans is a common practice, in which fermentation is one of the processes. Despite its significance, fermentation also alters the bioactive components in cacao beans. To develop a functional food rich in bioactive compounds, measuring the bioactive contents of treated and untreated cacao beans is desired. For that reason, in this study, the analysis of total polyphenol, flavonoid, catechin, and epicatechin, as well as the radical scavenging activity of fermented cacao beans, was performed. The study revealed that fermentation negatively affected all parameters. Cacao beans fermentation up to 96 h resulted in the loss of 54% of total polyphenol, 77% of total flavonoid, and 56% of radical scavenging activity. Determination of the flavan-3-ol components, catechin, and epicatechin, revealed that they were reduced as the fermentation occurred.
A validation study for wide-range remote assessment of cognitive functions in the healthy older Japanese population: a pilot randomized crossover trial
Authors: Takakura Yuki , Otsuki Mika , Takagi Ryo , Houkin Kiyohiro 
Published: March 2023

Abstract
Background
To determine the feasibility and reliability of previously unvalidated remote cognitive function tests in Japan using common information and communication technology (ICT) devices, software, and video teleconference (VTC) system compared with face-to-face (FTF) assessment.
Methods
The sample consisted of 26 participants from senior citizens clubs and an employment service center in Sapporo Japan, including 11 females and 15 males (age averaged 78.6 ± 6.8 years). Tests included the RCPM, Story recall, 10/36 spatial recall, selective reminding test, SDMT, PASAT, FAB, TMT-A, TMT-B, visual cancellation task, digit span, tapping span. The experimental design was a counter-balanced cross-over randomized controlled trial. Intraclass correlations (ICCs), paired-samples t-tests, Cohen's Kappa (κ) coefficients, and Wilcoxon signed-rank test were calculated to compare the scores between VTC and FTF assessments.
Results
All ICCs were significant and ranged from 0.47 (RCPM time) to 0.92 (RCPM score and PASAT), with a mean ICC of 0.75. Digit span using Cohen's Kappa (κ) coefficient was significant, but the tapping span was not. Paired samples t-test showed statistically significant differences in SDMT, RCPM time, and cancellation time.
Conclusions
The results suggest that remote video conference-based neuropsychological tests even using familiar devices and software may be able to assess a wide range of cognitive functions in the Japanese older population. As for the processing speed tasks, we need to create our own standards for the remote condition. For the tapping span, we should consider increasing the number of trials.
A-SOiD, an active learning platform for expert-guided, data efficient discovery of behavior.
Authors: Yttri Eric , Hsu Alexander , Schweihoff Jens , Schwarz Martin 
Published: March 2023

Abstract
Behavior identification and quantification techniques have undergone rapid development. To this end, supervised or unsupervised methods are chosen based upon their intrinsic strengths and weaknesses (e.g. user bias, training cost, complexity, action discovery). Here, a new active learning platform, A-SOiD, blends these strengths and in doing so, overcomes several of their inherent drawbacks. A-SOiD iteratively learns user-defined groups with a fraction of the usual training data while attaining expansive classification through directed unsupervised classification. In socially-interacting mice, A-SOiD outperformed standard methods despite requiring 85$\%$ less training data. Additionally, it isolated two additional ethologically-distinct mouse interactions via unsupervised classification. Similar performance and efficiency was observed using non-human primate 3D pose data. In both cases, the transparency in A-SOiD’s cluster definitions revealed the defining features of the supervised classification through a game-theoretic approach. To facilitate use, A-SOiD comes as an intuitive, open-source interface for efficient segmentation of user-defined behaviors and discovered subactions.
An Experimental Study on the Impact of Prosthesis Temperature on the Biomechanical Properties of Bone Cement Fixation
Authors: Chen Wanzhuo , Zhang Haining 
Published: March 2023

Abstract
Purpose
To investigate the effect of femoral component and tibial plateau component temperature on the strength of cement fixation during total knee arthroplasty (TKA).
Methods
Femoral prosthesis,tibial plateau prosthesis and polypropylene mold base were used to simulate TKA for bone cement fixation.Pre-cooling or pre-warming of femoral and tibial plateau components at different temperatures (4°C,15°C,25°C,37°C,45°C),followed by mixing and stirring of bone cement at laboratory room temperature (22°C),were performed during research.The prosthesis and the base were adhered together,and the bone cement was solidified for 24 hours at a constant temperature of 37°Cto verify the hardness of the bone cement with a push-out test.
Results
The push-out force of the femoral prosthesis after fixation was higher than that of the tibial plateau prosthesis,and with the increase of the prosthesis temperature,the push-out force after fixation of the bone cement also increased linearly and the porosity of the prosthetic cement in the tibia and femur decreased as the temperature increased.
Conclusion
Without changing the mixing temperature and solidification temperature,the fixation strength of the femoral prosthesis is higher than that of the tibial plateau prosthesis.Properly increasing the temperature of the prosthesis can increase the push-out force of the fixation strength.
Inhibitory activity of hydroalcoholic extract of Anancardium occidentale L. leaves against Brugia malayi hexokinase, a target for anti-filarial drug development
Authors: Kaushik Meenakshi , Hoti Sugeerappa L. , Saxena Jitendra Kumar , Joshi Rajesh , Singh Ishwar , Metgud Sharada , Hegde Harsha V. 
Published: March 2023

Abstract
Purpose: Globally, 859 million people in 50 countries are threatened by lymphatic filariasis. Due to its severity, the available drugs are mainly used for microfilaricidal and do not kill efficiently the adult parasites, which continue to produce microfilariae. Therefore, the present study aims to develop a plant-based macrofilaricidal drug.
Methods: The inhibitory activity of the various solvent extracts of the leaves of Anacardium occidentale L. (Anacardiaceae) was tested against the recombinant hexokinase of B. malayi (BmHk). BmHK, an enzyme of the glycolytic pathway that plays a vital role in the replication/survival of filarial parasites, was chosen as a target. A preliminary phytochemical test and GC-FID analysis of the extract were carried out.
Results: The hydroalcoholic extract of A. occidentale showed the highest inhibition (65.80±1.60%) of activity of BmHk, compared to other extracts, which showed less than 50% inhibition.
Conclusion: The present study showed that hydroalcoholic extract of A. occidentale has inhibitory activity against BmHk and can be explored further for developing the herbal-based anti-filarial drug.
Evaluation of the cytotoxic and genotoxic effects of 2 Fluquinconazole using Allium cepa L. as a bioindicator
Authors: türkoğlu şifa 
Published: March 2023

Abstract
Fluquinconazole is the active substance of a synthetic fungicide which is used extensively in agricultural areas in the world and Turkey. In this study, 30, 60, 90 and 100 mg/l doses of the substance were applied to Allium cepa root tips for 12, 24 and 48 hours. Distilled water was used as a negative control while methyl methane sulfonate (MMS, 10 ppm) was used as a positive control. As a result of the application, it was observed that the substance caused mitotic inhibition by decreasing the mitotic index, leading to changes in mitotic stage ratios. It was also observed that this substance caused chromosomal (anaphase bridges, stickiness, c-mitosis, laggards, and breakages) and nuclear abnormalities (binucleus and micronucleus). At the end of the statistical analysis and examinations, it was detected that the substance caused cytotoxic and genotoxic effects.