bluuebunny/crossref_metadata_2025_split huggingface dataset:
Saudi patients outcomes after surgical treatment of adolescent idiopathic scoliosis
Authors: Alzakri Abdulmajeed , AlMuhid Faisal , Almousa Nasser , Aljehani Muaath , Alhalabi Hashem 
Published: June 2023

Abstract
Background
In order to improve post-operative patient’s quality-of-life, attention must be paid to the identification of factors that play a role in patient’s satisfaction with surgical treatment. Patient satisfaction with the outcomes of scoliosis surgery has not been addressed so comprehensively in Saudi literature, as well as the effect of patient satisfaction on the different domains of the SRS-22 questionnaire and radiographic parameters is yet to be reported locally. The aim of this study is to explore such findings especially in our population.

Methods
A retrospective cohort study was conducted at two of the largest centers of spine surgery in the Kingdom of Saudi Arabia. A total of 316 eligible patients were selected via consecutive sampling technique. Data were collected from eligible patients who fit our inclusion criteria, which includes patients with adolescent idiopathic scoliosis aged from 10 to 21 years. Student t test, Pearson’s and Spearman’s correlation coefficients statistical tests were used.

Results
There were 283 (89.6%) females and 33 (10.4%) male patients with a mean age of 15.09 (± 2.27 SD) years. All the domains of SRS-22 showed significantly higher scores 2-year postoperatively, when compared with preoperative values (P < 0.001). The change in all SRS-22 domains correlated positively and significantly with the 2-year postoperative satisfaction using Pearson’s correlation coefficient (P < 0.05); the total score showed the highest correlation followed by the self-image domain. The major Cobb angle correction percentage correlated significantly (P < 0.05) solely with the change in pain domain.

Conclusion
Self-image correlated highly and significantly with patient satisfaction postoperatively. It also had the biggest influence SRS-22 scores postoperatively in conjunction with satisfaction scores. That is an indication of the role it plays in patient satisfaction and quality-of-life postoperatively, which may influence the surgical decision making.
Lumbosacral fusion increases the risk of hip osteoarthritis
Authors: Ulusoy İbrahim , Kıvrak Aybars 
Published: June 2023

Abstract
Objective
There may be biomechanical changes in the adjacent hip joint after lumbosacral fusion. The literature has limited information on how these biomechanical changes may result in hip joint space.

Material

method
Our retrospective study examined hip joint space narrowing in patients who underwent lumbosacral fusion between 2020 and 2022. In addition, spinopelvic parameters such as sacral slope, the sagittal vertical axis, pelvic incidence, lumbar lordosis, and pelvic tilt were compared in patients who underwent short-segment (up to three levels, S group) and long-segment (4 and higher levels, L group) fusions.

Results
Our study found no significant relationship between spinopelvic parameters and joint space narrowing in the S and L groups. In addition, it was determined that there was more narrowing in the hip joint space in the long-segment group, and there was a positive correlation between the segment length and the narrowing in the hip joint space.

Conclusion
After lumbosacral fusion, narrowing of the hip joint space was observed. Particularly patients with long-segment lumbosacral fusion should be followed closely regarding hip osteoarthritis risk.
Easing pandemic-related restrictions, easing psychosocial stress factors in families with infants and toddlers? Cross-sectional results of the three wave CoronabaBY study from Germany
Authors: Friedmann Anna , Buechel Catherine , Seifert Clara , Eber Stefan , Mall Volker , Nehring Ina 
Published: June 2023

Abstract
Background
Families with young children are particularly vulnerable for the stressors induced by the COVID-19 pandemic. However, studies on their psychosocial situation during the course of the crisis are still sparse.

Methods
In a comparison of three survey waves (wave I and III = high COVID-19 incidences), we cross-sectionally investigated the proportion of families (Ntotal = 2940) with children aged 0–3 years experiencing pandemic burden, parenting stress, and parental and child mental health problems in relation to COVID-19 incidences and restrictions in Southern Germany via validated questionnaires. Potential influencing factors were also explored.

Results
The number of parents with a high pandemic burden decreased over the course of the pandemic with a peak of 65.3% in wave I (significant changes except wave II versus III). Participants with high parenting stress significantly increased from 38.2% in wave I to 51.2% in wave III. The number of parents with symptoms of depression and anxiety remained constantly high with a maximum of 28.4% being affected. Infants with crying/sleeping problems increased significantly from 26.4% in wave I to 35.5% in wave III. Toddlers’ emotional and behavioral problems showed a peak of 23.9% in wave III (no significant changes). Increased family conflicts were the strongest predictor for parenting stress (ß = 0.355), maternal (ß = 0.305), infants’ (ß = 0.149) and toddlers’ (ß = 0.216) mental health problems during the pandemic.

Conclusions
Psychosocial stress factors in families with infants and toddlers remained highly pronounced and even partly increased irrespective of pandemic events. The findings suggest a staggered negative impact of pandemic-related factors on young children’s mental health. Promoting infants’ mental health as well as strengthening parental resources by reducing parenting stress should be a top healthcare priority in the aftermath of COVID-19.
Trial registration The study was pre-registered in OSF (https://osf.io/search/?q=tksh5&page=1)
scTour: a deep learning architecture for robust inference and accurate prediction of cellular dynamics
Authors: Li Qian 
Published: June 2023

AbstractDespite the continued efforts, a batch-insensitive tool that can both infer and predict the developmental dynamics using single-cell genomics is lacking. Here, I present scTour, a novel deep learning architecture to perform robust inference and accurate prediction of cellular dynamics with minimal influence from batch effects. For inference, scTour simultaneously estimates the developmental pseudotime, delineates the vector field, and maps the transcriptomic latent space under a single, integrated framework. For prediction, scTour precisely reconstructs the underlying dynamics of unseen cellular states or a new independent dataset. scTour’s functionalities are demonstrated in a variety of biological processes from 19 datasets.
Accuracy of the estimations of respiratory mechanics using an expiratory time constant in passive and active breathing conditions: a bench study
Authors: Chen Yuqing , Yuan Yueyang , Zhang Hai , Li Feng 
Published: June 2023

Abstract
Background
Respiratory mechanics monitoring provides useful information for guiding mechanical ventilation, but many measuring methods are inappropriate for awake patients. This study aimed to evaluate the accuracy of dynamic mechanics estimation using expiratory time constant (RCexp) calculation during noninvasive pressure support ventilation (PSV) with air leak in different lung models.

Methods
A Respironics V60 ventilator was connected to an active breathing simulator for modeling five profiles: normal adult, restrictive, mildly and severely obstructive, and mixed obstructive/restrictive. Inspiratory pressure support was adjusted to maintain tidal volumes (VT), achieving 5.0, 7.0, and 10.0 ml/kg body weight. PEEP was set at 5 cmH2O, and the back-up rate was 10 bpm. Measurements were conducted at system leaks of 25–28 L/min. RCexp was estimated from the ratio at 75% exhaled VT and flow rate, which was then used to determine respiratory system compliance (Crs) and airway resistance (Raw).

Results
In non-obstructive conditions (Raw ≤ 10 cmH2O/L/s), the Crs was overestimated in the PSV mode. Peak inspiratory and expiratory flow and VT increased with PS levels, as calculated Crs decreased. In passive breathing, the difference of Crs between different VT was no significant. Underestimations of inspiratory resistance and expiratory resistance were observed at VT of 5.0 ml/kg. The difference was minimal at VT of 7.0 ml/kg. During non-invasive PSV, the estimation of airway resistance with the RCexp method was accurately at VT of 7.0 ml/kg.

Conclusions
The difference between the calculated Crs and the preset value was influenced by the volume, status and inspiratory effort in spontaneously breathing.
A prospective survey on trephine biopsy of bone and bone marrow: an experience with 274 Indian patients’ biopsies
Authors: Nadda Rahul , Repaka Ramjee , Mallik Nabhajit , Sahani Ashish Kumar 
Published: June 2023

AbstractTrephine bone marrow biopsy is an effective technique for diagnosing hematological malignancies in patients of different ages. During trephine biopsy, bone marrow cores are obtained for detailed morphological evaluation to look for any abnormality and arrive at a diagnosis. The primary goal of this work is to perform a survey on Indian patients of various ages for the trephine bone marrow biopsy process. In the present study, data related to 274 trephine biopsy samples from 300 patients were acquired at the Post Graduate Institute of Medical Education and Research (PGIMER) in Chandigarh, India. Pain was found to be the sole major procedure-related complication, and patients reported no/less pain in 41 BMB (14.96%) patients, moderate pain in 82 (29.92%) cases, and unbearable pain in 151 (55.1%) BMB cases. In addition, the patients were evaluated by the authors and hematologist as non-anxious for the procedure in 34 (12.4%), anxious in 92 (33.57%), and very/highly anxious in 148 (56%) cases. The bone texture of the patients significantly affected the needle bending, number of repetitions required, and size of the bone marrow sample. This demonstrates the need for improvement in the biopsy procedure. To this end, a survey was conducted to assess the numerous difficulties and diagnostic outcomes throughout the trephine biopsy process.
Predator telemetry informs temporal and spatial overlap with stocked salmonids in Lake Huron
Authors: Fielder David G. , Hayden Todd A. , Binder Thomas R. , Dorr Brian S. , Currier Heidi A. 
Published: June 2023

AbstractDouble-Crested Cormorants (Phalacrocorax auratus), Walleyes (Sander vitreus), and Lake Trout (Salvelinus namaycush) are migratory predators that undergo extensive movements in Lake Huron. Stocking of juvenile salmonid fish (OncorhynchusandSalmosp.) is an important component of fishery management in Lake Huron and assessing the spatial and temporal extent of predator movements is a useful consideration for determining when and where to stock juvenile fish to reduce predation and maximize survival. Previous investigation indicated that some Walleyes migrate to the main basin of Lake Huron in spring from Saginaw Bay. Similarly, telemetry studies of Lake Trout movement in Lake Huron have indicated an onshore movement in the spring. We used detection histories of Walleyes implanted with acoustic transmitters tagged in Saginaw Bay and Lake Trout implanted in northern Lake Huron to estimate the arrival date of migrating adults at eight ports in Lake Huron, where hatchery reared juvenile salmonids are stocked. Satellite telemetry of Cormorants that return to nesting grounds in northern Lake Huron were used to estimate their arrival dates at the same Lake Huron ports. Arrival of Walleye at Lake Huron ports ranged from April 10th to May 7th. Cormorants arrived earlier than Walleye at most Lake Huron ports (April 11th–April 18th). Lake Trout were more variable with a range of onshore movement from March 28th to May 16th. Our results suggested stocking efforts at these ports should generally occur before April 14th to decrease predatory impact from Cormorants, Walleyes, and Lake Trout.
Assessment of an exhaled breath test using ultraviolet photoionization time-of-flight mass spectrometry for the monitoring of kidney transplant recipients
Authors: Feng Shijian , Xiang Chengfang , He Yushi , Li Zhuoya , Zhao Zhongjun , Liu Bohan , Yin Zhaofa , He Qiyu , Yang Yanting , Huang Zhongli , Lin Tao , Li Wenwen , Duan Yixiang 
Published: June 2023

AbstractContinuous monitoring for immunosuppressive status, infection and complications are a must for kidney transplantation (KTx) recipients. Traditional monitoring including blood sampling and kidney biopsy, which caused tremendous medical cost and trauma. Therefore, a cheaper and less invasive approach was urgently needed. We thought that a breath test has the potential to become a feasible tool for KTx monitoring. A prospective-specimen collection, retrospective-blinded assessment strategy was used in this study. Exhaled breath samples from 175 KTx recipients were collected in West China Hospital and tested by online ultraviolet photoionization time-of-flight mass spectrometry (UVP-TOF–MS). The classification models based on breath test performed well in classifying normal and abnormal values of creatinine, estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN) and tacrolimus, with AUC values of 0.889, 0.850, 0.849 and 0.889, respectively. Regression analysis also demonstrated the predictive ability of breath test for clinical creatinine, eGFR, BUN, tacrolimus level, as the predicted values obtained from the regression model correlated well with the clinical true values (p < 0.05). The findings of this investigation implied that a breath test by using UVP-TOF–MS for KTx recipient monitoring is possible and accurate, which might be useful for future clinical screenings.
Long-term Efficacy and Safety of Pasireotide in Patients With Acromegaly: 14 Years of Single-Center Real-World Experience
Authors: Gadelha Mônica , Marques Nelma Verônica , Fialho Christhiane , Scaf Cristiane , Lamback Elisa , Antunes Ximene , Santos Erica , Magalhães Jaqueline , Wildemberg Luiz Eduardo 
Published: June 2023

Abstract

Context
Acromegaly is a rare, chronic, debilitating disorder caused by prolonged hypersecretion of growth hormone (GH) and overproduction of insulin-like growth factor I (IGF-I). Medical therapies, including the somatostatin receptor ligand (SRL) pasireotide, are frequently used to restore biochemical control.

Objective
As patients often receive therapy over prolonged periods, long-term data from real-life settings are needed.

Methods
A retrospective analysis was performed using a prospectively maintained database of all patients with acromegaly from our primary care center who were enrolled in clinical studies with pasireotide (first visit November 2008). The main outcome measures were safety and biochemical control (age-adjusted IGF-I ≤ upper limit of normal).

Results
Patients (n = 50) entered 4 parental studies and 30 continued in the rollover; at data cutoff (June 2022), 27 were still receiving pasireotide. Overall, median (range) exposure was 58 (3-137) months. Normal IGF-I was achieved in 54%, and acromegaly symptoms and quality of life were improved with treatment. No predictors of pasireotide response were identified; however, controlled patients had smaller tumors and lower GH at baseline. Tumor volume reduction occurred in 63% of evaluable patients (n = 10/16). Most patients presented hyperglycemic events, including 63.2% of patients with normal glucose before treatment. Older patients and those with higher IGF-I, glucose, and HbA1c at baseline had higher glucose and HbA1c during pasireotide treatment.

Conclusion
Pasireotide provided clinical benefit and was well tolerated for more than 11 years of treatment in acromegaly patients, most of whom were resistant to first-generation SRLs.
Developing an Automated Registry (Autoregistry) of Spine Surgery Using Natural Language Processing and Health System Scale Databases
Authors: Cheung Alexander T. M. , Kurland David B. , Neifert Sean , Mandelberg Nataniel , Nasir-Moin Mustafa , Laufer Ilya , Pacione Donato , Lau Darryl , Frempong-Boadu Anthony K. , Kondziolka Douglas , Golfinos John G. , Oermann Eric Karl 
Published: June 2023

BACKGROUND AND OBJECTIVES:
Clinical registries are critical for modern surgery and underpin outcomes research, device monitoring, and trial development. However, existing approaches to registry construction are labor-intensive, costly, and prone to manual error. Natural language processing techniques combined with electronic health record (EHR) data sets can theoretically automate the construction and maintenance of registries. Our aim was to automate the generation of a spine surgery registry at an academic medical center using regular expression (regex) classifiers developed by neurosurgeons to combine domain expertise with interpretable algorithms.

METHODS:
We used a Hadoop data lake consisting of all the information generated by an academic medical center. Using this database and structured query language queries, we retrieved every operative note written in the department of neurosurgery since our transition to EHR. Notes were parsed using regex classifiers and compared with a random subset of 100 manually reviewed notes.

RESULTS:
A total of 31 502 operative cases were downloaded and processed using regex classifiers. The codebase required 5 days of development, 3 weeks of validation, and less than 1 hour for the software to generate the autoregistry. Regex classifiers had an average accuracy of 98.86% at identifying both spinal procedures and the relevant vertebral levels, and it correctly identified the entire list of defined surgical procedures in 89% of patients. We were able to identify patients who required additional operations within 30 days to monitor outcomes and quality metrics.

CONCLUSION:
This study demonstrates the feasibility of automatically generating a spine registry using the EHR and an interpretable, customizable natural language processing algorithm which may reduce pitfalls associated with manual registry development and facilitate rapid clinical research.
DNA barcoding Clithon sp. (Gastropoda: Neritidae) from Badur Beach, Madura, Indonesia, based on COI gene molecular marker
Authors: DJOEMHARSJAH INTAN SALSABILA , AMBARWATI RENI , RAHAYU DWI ANGGOROWATI 
Published: June 2023

Abstract. Djoemharsjah IS, Ambarwati R, Rahayu DA. 2023. DNA barcoding Clithonsp. (Gastropoda: Neritidae) from Badur Beach, Madura, Indonesia, based on COI gene molecular marker. Biodiversitas 24: xxxx. Neritidae is polymorphic with various shell colors and patterns; therefore, they were doubts about the identifying species from the genus Clithon, namely Clithon sp. from Badur Beach of Madura Island, Sumenep District, East Java Province, Indonesia. In addition, DNA barcoding could provide genetic information using short DNA sequences to quickly and precisely identify species. This study aimed to identify the genus Clithon sp. from Badur Beach, based on Cytochrome Oxidase subunit I(COI) genes and analysis of phylogenetic relationships. The research methods include sampling, sample preservation, morphological identification of species, DNA isolation, amplification, electrophoresis, and sequencing using the Sanger method with genetic analysis using bioinformatics software. The results of COI barcode identification obtained a DNA sequence length of 490bp with a similarity value of the three Clithon sp. samples between 96.75 to 98.97%. The identification with the Barcode of Life Data System consisted of three variations of nucleotide bases, and the average value of the genetic distance with the in-group was 1.74% as Clithon sp. The Phylogenetic tree Clithon sp. from Badur Beach, was in the same clade as Clithon sowerbianum Récluz 1843 and Clithon mertonianum Récluz 1843 with the Neighbor-Joining Tree and Maximum Likelihood methods with bootstrap values between 96-100. Therefore, the COI barcode DNA markers analysis successfully identified Clithon sp. from Badur Beach, Madura, Indonesia as C. sowerbianum.
Phenotypic diversity of bamboo Schizostachyum lima (Blanco) Merr. population grown in several critical habitats on Lombok Island, Indonesia
Authors: ARYANTI EVY , ARUMINGTYAS ESTRI LARAS , AZRIANINGSIH RODLIYATI , ARISOESILANINGSIH ENDANG 
Published: June 2023

Abstract. Aryanti E, Arumingtyas EL, Azrianingsih R, Arisoesilaningsih E. 2023. Phenotypic diversity of bamboo Schizostachyum lima (Blanco) Merr. population grown in several critical habitats on Lombok Island, Indonesia. Biodiversitas 24: 2788-2796. This study aims to analyze the phenotypic diversity among populations of Schizostachyum lima (Blanco) Merr. grown in several critical habitats on Lombok Island. Sampling was conducted to record clump growth and habitat properties of 38 sites grouped based on the clump density using PAST 4.11 and ArcGIS 10.8.2 software. Sampling was conducted to record clump growth and habitat properties of 38 sites grouped based on the clump density using PAST 4.11 and ArcGIS 10.8.2 software. The results showed that habitat 1 was the most critical land and had the lowest fertility, but it provided a qualified bamboo as a raw material for the artisanal straw industry. The results showed that habitat 1 was the most critical land and had the lowest fertility, but it provided a qualified bamboo as a raw material for the artisanal straw industry. Bamboo density reached 46 culms per clump and had the smallest culms diameter of 13 mm. Bamboo density reached 46 culms per clump and had the smallest culms diameter of 13 mm. The soil comprised 90% sand, with SOC 0.9 g.kg-1, total N 0.08 g.kg-1, and CEC 8.3 me.100 g-1. The soil comprised 90% sand, with SOC 0.9 g.kg-1, total N 0.08 g.kg-1, and CEC 8.3 me.100 g-1. Meanwhile, habitat 6 and habitat 7 were lesser critical, consisted of 66% of sand, showed the best soil fertility, and mean SOC 4.98 g.kg-1, total N 0.30 g.kg-1, CEC 27.23 me.100 g-1, density 151 culms, and biggest culms diameter 33 mm. Meanwhile, habitat 6 and habitat 7 were lesser critical, consisted of 66% of sand, showed the best soil fertility, and mean SOC 4.98 g.kg-1, total N 0.30 g.kg-1, CEC 27.23 me.100 g-1, density 151 culms per clump, and biggest culms diameter 33 mm. The other habitats varied in soil quality and bamboo growth properties. It was revealed that the high culms density, diameter, height, and internodal length were significantly increased in the high soil CEC, SOC, and total N. Furthermore, the SOC and total N content significantly correlated with the wall thickness.