bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic code compression for JavaScript engine
Authors: Park Hyukwoo , Kim Seonghyun , Bae Boram 
Published: February 2023

AbstractWeb applications created using web languages such as HTML, CSS, and JavaScript are widely used regardless of execution environments, owing to their portability and popularity. Since JavaScript language is conventionally used for complex computations in large‐scale web apps, many optimization techniques have been proposed to accelerate the JavaScript performance. However, most of these optimizations speed up JavaScript engines at the expense of consuming more memory. Hence, memory consumption becomes an additional concern in the JavaScript field. Based on the research on memory status, we unearthed that a substantial portion of the heap memory is allocated for JavaScript source code, particularly in lightweight JavaScript engines, which may range from 13.2% to a maximal 52.5% of the entire heap. To resolve this memory issue, this article suggests a new memory optimization method, called dynamic code compression that dynamically compresses the source code and keeps its compressed form instead of the source string. A novel heuristic is proposed to timely compress the source code. We also re‐design the internal structure of the JavaScript engine to efficiently compress the source code without incurring any conflict. Using our code compression method, we could reduce the entire heap memory by up to 43.3% and consistently downsize the overall heap size. From an evaluation of standard benchmarks, our approach showed just 2.7% degradation in performance with negligible compression overhead, proving the feasibility of the code compression technique.
Experimentelle Untersuchungen an neuartigen Hohlprofil‐Verbundstützen mit Blechlamellen aus hochfesten Stählen im Kalt‐ und Brandfall
Authors: Schäfers Michael , Ameri Shaghayegh , Mensinger Martin , Zehfuß Jochen 
Published: February 2023

AbstractBesonders leistungsfähige Verbundstützen werden traditionell meist mit Vollstahlquerschnitten als Kernprofil eingesetzt. Diese weisen durch Abminderungen der Streckgrenze bei höheren Dicken nach DIN EN 1993‐1‐1:2010‐12 und hohen Eigenspannungen Limitierungen auf. In diesem Beitrag stellen die Autoren einen innovativen Querschnitt vor, der aus lokal verbundenen Blechlamellen in einem Hohlprofil mit Betonfüllung besteht. Zur Steigerung der Traglasten kommen hierbei Stähle mit Streckgrenzen bis zu 960 N/mm2 zum Einsatz. Es werden die experimentellen Untersuchungen und erste Ergebnisse im Kalt‐ und Brandfall präsentiert. Dabei zeigen die Stützen mit dem neuartigen Querschnitt ein verlässliches Tragverhalten. Die Untersuchungen dienen als Grundlage zur systematischen Entwicklung dieses neuen, hochleistungsfähigen Verbundstützentyps sowie eines dazugehörigen Bemessungskonzepts.
Release of neutrophil extracellular traps in response to Candida albicans yeast, as a secondary defense mechanism activated by phagocytosis
Authors: Zawrotniak Marcin , Juszczak Magdalena , Rapała‐Kozik Maria 
Published: February 2023

AbstractCandida albicans is one of the main pathogens responsible for the development of difficult‐to‐fight fungal infections called candidiasis. Neutrophils are the major effector cells involved in the eradication of fungal pathogens. This group of immune cells uses several mechanisms that enable the rapid neutralization of pathogens. The most frequently identified mechanisms are phagocytosis and the release of neutrophil extracellular traps (NETs). The mechanism for selecting the type of neutrophil immune response is still unknown. In our study, we analyzed the relationship between the activation of phagocytosis and netosis. We detected the presence of two neutrophil populations characterized by different response patterns to contact with C. albicans blastospores. The first neutrophil population showed an increased ability to rapidly release NETs without prior internalization of the pathogen. In the second population, the netosis process was inherently associated with phagocytosis. Differences between populations also referred to the production of reactive oxygen species. Our results suggest that neutrophils use different strategies to fight C. albicans and, contrary to previous reports, these mechanisms are not mutually exclusive.
Behavioral development of a captive polar bear (Ursus maritimus) cub in the maternal den
Authors: Gartland Kylen N. , Humbyrd Mary K. , Meister Betsie , Fuller Grace 
Published: February 2023

AbstractTwo female polar bear (Ursus maritimus) cubs were born to mother Suka at the Detroit Zoo on November 17, 2020. One cub (Lærke) was hand‐reared out of medical necessity, while the other cub (Astra) was mother‐reared. Using audio‐equipped video cameras previously installed in the maternal den, staff were able to conduct uninterrupted continuous monitoring on Suka and Astra for an unprecedented 12 weeks. Data collected during this time were analyzed descriptively. Astra spent a maximum of approximately 20% of any given 24 h period in nursing behaviors. Distribution of time spent nursing was relatively even across the 24 h day. In contrast to the limited data currently available, Astra spent only approximately 11% of the over 2000 h of behavioral data engaged in nursing behaviors. Astra left the nest for the first time in her fourth week of life, and time spent out of the nest gradually increased with age. Suka was observed guiding Astra back to the nest the first few times Astra ventured out. However, maintenance of maternal proximity did not appear to be a motivating factor in patterns of space use. The data presented here represent the longest uninterrupted continuous monitoring of a polar bear cub in the maternal den currently published. Publication of similar data from other institutions would establish more generalizable trends for early infancy development. These data are critical for understanding cub welfare and improving population sustainability and neonate mortality rates.
Dilution of dark matter relic density in singlet extension models
Authors: Xiao Yang , Yang Jin Min , Zhang Yang 
Published: February 2023

AbstractWe study the dilution of dark matter (DM) relic density caused by the electroweak first-order phase transition (FOPT) in the singlet extension models, including the singlet extension of the standard model (xSM), of the two-Higgs-doublet model (2HDM+S) and the next-to-minimal supersymmetric standard model (NMSSM). We find that in these models the entropy released by the strong electroweak FOPT can dilute the DM density to 1/3 at most. Nevertheless, in the xSM and NMSSM where the singlet field configure is relevant to the phase transition temperature, the strong FOPT always happens before the DM freeze-out, making the dilution effect negligible for the current DM density. We derive an analytical upper bound on the freeze-out temperature and a numerical lower bound on nucleation temperature in the xSM. On the other hand, in the 2HDM+S where the DM freeze-out temperature is independent of FOPT, the dilution may salvage some parameter space excluded by excessive DM relic density or by DM direct detections.
D4-branes wrapped on four-dimensional orbifolds through consistent truncation
Authors: Couzens Christopher , Kim Hyojoong , Kim Nakwoo , Lee Yein , Suh Minwoo 
Published: February 2023

Abstract
We construct a consistent truncation of six-dimensional matter coupled F(4) gauged supergravity on a cornucopia of two-dimensional surfaces including a spindle, disc, domain wall and other novel backgrounds to four-dimensional minimal gauged supergravity. Using our consistent truncation we uplift known AdS2× Σ1 solutions giving rise to four-dimensional orbifold solutions, AdS2× Σ1 ⋉ Σ2. We further uplift our solutions to massive type IIA supergravity by constructing the full uplift formulae for six-dimensional U(1)2-gauged supergravity including all fields and arbitrary Romans mass and gauge coupling. The solutions we construct are naturally interpreted as the near-horizon geometries of asymptotically AdS6 black holes with a four-dimensional orbifold horizon. Alternatively, one may view them as the holographic duals of superconformal quantum mechanical theories constructed by compactifying five-dimensional USp(2N) theory living on a stack of D4-D8 branes on the four-dimensional orbifolds. As a first step to identifying these quantum mechanical theories we compute the Bekenstein-Hawking entropy holographically.
A scotogenic model with two inert doublets
Authors: Ahriche Amine 
Published: February 2023

Abstract
In this work, we present a scotogenic model, where the neutrino mass is generated at one-loop diagrams. The standard model (SM) is extended by three singlet Majorana fermions and two inert scalar doublets instead of one doublet as in the minimal scotogenic model. The model scalar sector includes two CP-even, two CP-odd and two charged scalars in addition to the Higgs. The dark matter (DM) candidate could be either the light Majorana fermion (Majorana DM), or the lightest among the CP-even and the CP-odd scalars (scalar DM). We show that the model accommodates both Majorana and scalar DM within a significant viable parameter space, while considering all the relevant theoretical and experimental constraints such as perturbativity, vacuum stability, unitarity, the di-photon Higgs decay, electroweak precision tests and lepton flavor violating constraints. In addition to the collider signatures predicted by the minimal scotogenic model, our model predicts some novel signatures that can be probed through some final states such as "Image missing".
Chiral dualities for SQCD3 with D-type superpotential
Authors: Amariti Antonio , Morgante Davide 
Published: February 2023

Abstract
We study dualities for 3d U(Nc)kchiral SQCD with Dn+2-type superpotential, with n odd. We give a complete classification of such dualities in terms of the number of fundamentals and anti-fundamentals and the Chern-Simons level. The classification is obtained by real mass and Higgs flows from non-chiral dualities and we check the consistency of the new non-chiral dualities at the level of the partition function. We also check that the complex phases appearing in the integral identities between the partition functions are consistent with the contact terms computed as quantum corrections to the effective Chern-Simons level. The SU(Nc)k cases are recovered by gauging the topological symmetry from the U(Nc) dualities. Finally, we consider the case of USp(2Nc)2k with two antisymmetric tensors and Dn+2-type superpotential.
Late-time correlation functions in dS3/CFT2 correspondence
Authors: Chen Heng-Yu , Chen Shi , Hikida Yasuaki 
Published: February 2023

Abstract
We compute the late-time correlation functions on three-dimensional de Sitter spacetime for a higher-spin gravity theory. For this, we elaborate on the formulation to obtain the wave functional of universe from a dual conformal field theory, which is used to compute the late-time correlation functions. We argue that the relation to direct bulk Feynman diagram computations in the in-in formulation. We furthermore provide a precise prescription to construct a higher-spin dS3 holography as an analytic continuation of Gaberdiel-Gopakumar duality for AdS3. Part of results here were already reported in an earlier letter. We explain the details of their derivations and extend the analysis to more generic cases in this paper. Previously, we have examined two- and three-point functions and a simple four-point correlator at the leading order in Newton constant. Here we also evaluate more complicated four-point correlators. Finally, we study late-time correlators in an alternative limit of dS3/CFT2 with critical level coset, such as, two-point correlator on conical defect geometry. We also examine one-loop corrections to two-point correlator on dS3.
Thermal correlators and bosonization dualities in large N Chern-Simons matter theories
Authors: Ghosh Sudip , Mazumdar Subhajit 
Published: February 2023

Abstract
We consider 3-dimensional conformal field theories with U(N)κ Chern-Simons gauge fields coupled to bosonic and fermionic matter fields transforming in the fundamental representation of the gauge group. In these CFTs, we compute in the ’t Hooft large N limit and to all orders in the ’t Hooft coupling λ = N/κ, the thermal two-point correlation functions of the spin s = 0, s = 1 and s = 2 gauge invariant conformal primary operators. These are the lowest dimension single trace scalar, the U(1) current and the stress tensor operators respectively. Our results furnish additional tests of the conjectured bosonization dualities in these theories at finite temperature.
General light-cone gauge approach to conformal fields and applications to scalar and vector fields
Authors: Metsaev R. R. 
Published: February 2023

Abstract
Totally symmetric arbitrary spin conformal fields propagating in the flat space of even dimension greater than or equal to four are studied. For such fields, we develop a general ordinary-derivative light-cone gauge formalism and obtain restrictions imposed by the conformal algebra symmetries on interaction vertices. We apply our formalism for the detailed study of conformal scalar and vector fields. For such fields, all parity-even cubic interaction vertices are obtained. The cubic vertices obtained are presented in terms of dressing operators and undressed vertices. We show that the undressed vertices of the conformal scalar and vector fields are equal, up to overall factor, to the cubic vertices of massless scalar and vector fields. Various conjectures about interrelations between the cubic vertices for conformal fields in conformal invariant theories and the cubic vertices for massless fields in Poincaré invariant theories are proposed.
Development of an automated fibre placement-based hybrid composite wheel for a solar-powered car
Authors: Air Alexander , Shamsuddoha Md , Oromiehie Ebrahim , Prusty B. Gangadhara 
Published: February 2023

Abstract
Substantial range, handling and acceleration improvements in high-performance vehicles can be achieved by weight reduction. An important area for weight reduction on a car is the wheels. A novel prototype carbon fibre/epoxy wheel has been developed using a combination of automated fibre placement (AFP) and hand layup for the Sunswift 7 solar car. A three-piece wheel design that utilises each process where best suited has been analysed and optimised using the ANSYS ACP PrepPost suite, manufactured, and mechanically tested. The wheel disc was produced using AFP and featured selective reinforcement in the form of spokes. The AFP fibre paths for the disc have been optimised using CGTech’s VERICUT VCP and VCS to minimise gaps and overlaps, resulting in a 98.9% reduction in overlaps when compared with the unoptimised layup. The rim and tyre mounting region of the wheel have been manufactured using hand layup and adhesively bonded to the disc. This hybrid manufacturing approach has demonstrated an advancement in the feasibility of combining traditional and automated composite manufacturing. The final wheel weighed 3352 g, and the wheel deflection under a compressive load has been experimentally verified within 3% of the theoretical value.
Bootstrapping binary GEV regressions for imbalanced datasets
Authors: La Rocca Michele , Niglio Marcella , Restaino Marialuisa 
Published: February 2023

AbstractThis paper proposes and discusses a bootstrap scheme to make inferences when an imbalance in one of the levels of a binary variable affects both the dependent variable and some of the features. Specifically, the imbalance in the binary dependent variable is managed by adopting an asymmetric link function based on the quantile of the generalized extreme value (GEV) distribution, leading to a class of models called GEV regression. Within this framework, we propose using the fractional-random-weighted (FRW) bootstrap to obtain confidence intervals and implement a multiple testing procedure to identifying the set of relevant features. The main advantages of FRW bootstrap are as follows: (1) all observations belonging to the imbalanced class are always present in every bootstrap resample; (2) the bootstrap can be applied even when the complexity of the link function does not allow to easily compute second-order derivatives for the Hessian; (3) the bootstrap resampling scheme does not change whatever the link function is, and can be applied beyond the GEV link function used in this study. The performance of the FRW bootstrap in GEV regression modelling is evaluated using a detailed Monte Carlo simulation study, where the imbalance is present in the dependent variable and features. An application of the proposed methodology to a real dataset to analyze student churn in an Italian university is also discussed.
Clinical efficacy of flap transfer coverage in the treatment of vesicovaginal fistula
Authors: Wang Xingqi , Gao Zhenhua , Li Ling , Tian Daoming , Zhou Hang , Shen Jihong 
Published: February 2023

Abstract
Introduction and hypothesis
Vesicovaginal fistula (VVF) brings severe psychological, physiological, and social stress to patients, which seriously affects the quality of their sexual life. Traditional transvaginal repair surgery can cause vaginal shortening. Transferring the lateral free flap can maintain vaginal length. This study was carried out to investigate the clinical efficacy of the surgery of flap transfer coverage for treating VVF.

Methods
A retrospective analysis was performed on 37 patients diagnosed with VVF and repaired by flap transfer coverage in the Urogynecology department of the First Affiliated Hospital of Kunming Medical University from January 2018 to June 2021. All patients took a prone split leg position to repair VVF with the flap transfer covering method and a chart review was performed.

Results
Among the 37 patients, there were 34 cases of primary complete healing, and the success rate reached 91.89% without recurrence and complications. Three cases recurred with leakage of urine; cystoscopy showed that the fistula was significantly reduced, and all patients were cured after secondary repair by the same surgical method without complications.

Conclusions
Flap transfer coverage is a safe and effective surgical method for repairing VVF. The prone split leg position can better increase exposure. The fistula being away from the incision suture is the key to the success of the operation. Transferring the fistula can effectively improve the cure rate of VVF. Transferring the lateral free flap can maintain vaginal length.
Analysis of Hand Joint Space Morphology in Women and Men with Hereditary Hemochromatosis
Authors: Heilmeier Ursula , Burghardt Andrew J. , Tse Justin J. , Kapoor Puneet , Stok Kathryn S. , Manske Sarah , Voll Reinhard E. , Schett Georg , Finzel Stephanie 
Published: February 2023

AbstractHereditary hemochromatosis (HH) causes unbalanced iron deposition in many organs including the joints leading to severe cartilage loss and bone damage in the metacarpophalangeal joints (MCPJ). High-resolution peripheral quantitative computed tomography (HR-pQCT) and its joint space width (JSW) quantification algorithm quantifies in vivo 3D joint morphology. We therefore aimed to (i) determine feasibility and performance of the JSW algorithm in HH, (ii) quantify joint space morphology, and (iii) investigate the relationship between morphological and clinical parameters in HH. Here, we performed an exploratory study on 24 HH patients and sex- and age-matched controls using HR-pQCT imaging of MCPJ. Mineralized bone structure was automatically segmented from the grayscale image data and periosteal surface bone masks and joint space masks were generated. Mean, minimal, and maximal joint space width (JSW; JSW.MIN; JSW.MAX), JSW heterogeneity (JSW.SD), JSW asymmetry (JSW.AS), and joint space volume (JSV) were computed. Demographics and, for HH patients, disease-specific parameters were recorded. Segmentation of JS was very good with 79.7% of MCPJs successfully segmented at first attempt and 20.3% requiring semi-manual correction. HH men showed larger JSV at all MCPs (+ 25.4% < JSV <  + 41.8%, p < 0.05), larger JSW.MAX at MCP 3-4 (+ 14%, 0.006 < p < 0.062), and wider JSW (+ 13%, p = 0.043) at MCP 4 relative to HH women. Compared to controls, both HH men and HH women showed larger JSW.AS and smaller JSW.MIN at all MCP levels, reaching significance for HH men at MCP 2 and 3 (JSW.AS: + 323% < JSW.AS <  + 359%, 0.020 < p < 0.043; JSW.MIN: − 216% < JSW.MIN < − 225%, p < 0.043), and for women at MCP 3 (JSW.AS: + 180%, p = 0.025; JSW.MIN: − 41.8%, p = 0.022). Time since HH diagnosis was correlated positively with MCP 4 JSW.AS and JSW.SD (0.463 < ρ < 0.499, p < 0.040), and the number of phlebotomies since diagnosis was correlated with JSW.SD at all MCPs (0.432 < ρ < 0.535, p < 0.050). HR-pQCT-based JSW quantification in MCPJ of HH patients is feasible, performs well even in narrow JS, and allows to define the microstructural joint burden of HH.
A phase I, first-in-human study of TAK-164, an antibody–drug conjugate, in patients with advanced gastrointestinal cancers expressing guanylyl cyclase C
Authors: Kim Richard , Leal Alexis D. , Parikh Aparna , Ryan David P. , Wang Shining , Bahamon Brittany , Gupta Neeraj , Moss Aaron , Pye Joanna , Miao Harry , Inguilizian Haig , Cleary James M. 
Published: February 2023

Abstract
Purpose
Guanylyl cyclase C (GCC) is highly expressed in several gastrointestinal malignancies and preclinical studies suggest that it is a promising target for antibody-based therapeutics. This phase I trial assessed the safety and tolerability of TAK-164, an investigational, anti-GCC antibody–drug conjugate (NCT03449030).

Methods
Thirty-one patients with GCC-positive, advanced gastrointestinal cancers received intravenous TAK-164 on day 1 of 21-day cycles. Dose escalation proceeded based on cycle 1 safety data via a Bayesian model.

Results
Median age was 58 years (range 32–72), 25 patients (80.6%) had colorectal carcinoma, and median number of prior therapies was four. No dose-limiting toxicities (DLTs) were reported during cycle 1 DLT evaluation period. After cycle 2 dosing, 3 patients reported dose-limiting treatment-emergent adverse events (TEAEs): grade 3 pyrexia and grade 5 hepatic failure (0.19 mg/kg), grade 4 hepatic failure and platelet count decreased (0.25 mg/kg), grade 3 nausea, grade 4 platelet and neutrophil count decreased (0.25 mg/kg). The recommended phase II dose (RP2D) was 0.064 mg/kg. Common TAK-164-related TEAEs included platelet count decreased (58.1%), fatigue (38.7%), and anemia (32.3%). There was a dose-dependent increase in TAK-164 exposure over the range, 0.032–0.25 mg/kg. TAK-164 half-life ranged from 63.5 to 159 h. One patient (0.008 mg/kg) with high baseline GCC expression had an unconfirmed partial response.

Conclusions
TAK-164 appeared to have a manageable safety profile at 0.064 mg/kg. Hepatic toxicity was identified as a potential risk. The RP2D of 0.064 mg/kg was considered insufficient to derive clinical benefit; there are no plans for further clinical development.

Clinical Trial Registration
NCT03449030.