bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecological monitoring of emotional intensity, variability, and instability in individuals with schizophrenia spectrum disorders: Results of a multicentre study
Authors: Zarbo Cristina , Zamparini Manuel , Patrono Alessandra , Calini Cosima , Harvey Philip D. , Casiraghi Letizia , Clerici Massimo , Malvezzi Matteo , Rocchetti Matteo , Starace Fabrizio , de Girolamo Giovanni ,   DiAPAson Collaborators
Published: September 2023

AbstractBackgroundEvaluating emotional experiences in the life of people with Schizophrenia Spectrum Disorder (SSD) is fundamental for developing interventions aimed at promoting well‐being in specific times and contexts. However, little is known about emotional variability in this population. In DiAPAson project, we evaluated between‐ and within‐person differences in emotional intensity, variability, and instability between people with SSD and healthy controls, and the association with psychiatric severity and levels of functioning.Methods102 individuals diagnosed with SSD (57 residential patients, 46 outpatients) and 112 healthy controls were thoroughly evaluated. Daily emotions were prospectively assessed with Experience Sampling Method eight times a day for a week. Statistical analyses included ANOVA, correlations, and generalized linear models.ResultsParticipants with SSD, and especially residential patients, had a higher intensity of negative emotions when compared to controls. Moreover, all people with SSD reported a greater between‐person‐variability of both positive and negative emotions and greater intra‐variability of negative emotions than healthy controls. In addition, the emotion variability in people with SSD does not follow a linear or quadratic trend but is more “chaotic” if compared to controls.ConclusionsAdequate assessments of positive and negative emotional experiences and their time course in people with SSD can assist mental health professionals with well‐being assessment, implementing targeted interventions through the identification of patterns, triggers, and potential predictors of emotional states.
Association of Discharge Location Following Pediatric Tracheostomy with Social Determinants of Health: A National Analysis
Authors: Ramanathan Diya , Bruckman David , Appachi Swathi , Hopkins Brandon 
Published: September 2023

AbstractObjectiveTo evaluate the breakdown of discharge locations among pediatric tracheostomy patients and determine the impact of demographic variables and social determinants of health.Study DesignRetrospective review of the 2016 and 2019 Healthcare Cost and Utilization Project Kids' Inpatient Database (HCUP KID).SettingA total of 4000 United States community hospitals, defined as short‐term, non‐Federal, general, and specialty hospitals.MethodsICD‐10‐PCS, ICD‐10 CM codes, and HCUP data elements were selected for patients and variables of interest. Bivariate comparisons were performed using Rao‐Scott Chi‐square tests; significance levels in post hoc pairwise testing were adjusted using Bonferroni adjustment. Multinomial generalized logistic regression models were used to determine the average annual odds ratio (OR) of 3 dispositions at discharge relative to discharge home for self‐care.ResultsPatients aged 11‐17, patients from large metropolitan areas, and patients of “Other” race have an increased odds of discharge to a short‐ or long‐term care facility (all P < .001). Weekend admissions, nonelective admissions, patients in Northeast hospitals, and patients at urban nonteaching hospitals are also more likely to be discharged to a short‐ or long‐term care facility (all P < .001). Mean and median total costs of admission were $424,387 and $243,479, respectively, with a median total charge of $854,499.ConclusionAmong pediatric tracheostomy patients, demographic factors that affect discharge disposition include age, community type, and race, and significant hospital factors include day and type of admission, geographic region, and hospital type. Hospitalizations are associated with high overall costs and charges to the patient, which are increasing over time.
Can one hear the depth of the water?
Authors: Freitag Melina A. , Kříž Pavel , Mach Thomas , Nicolaus Jan Martin 
Published: September 2023

AbstractWe discuss discrete‐time dynamical systems depending on a parameter μ. Assuming that the system matrix is given, but the parameter μ is unknown, we infer the most‐likely parameter from an observed trajectory x of the dynamical system. We use parametric eigenpairs of the system matrix computed with Newton's method based on a Chebyshev expansion. We then represent x in the eigenvector basis defined by the and compare the decay of the components with predictions based on the . The resulting estimates for μ are combined using a kernel density estimator to find the most likely value for and a corresponding uncertainty quantification.
Why do we feel close to a person who expresses gratitude? Exploring mediating roles of perceived warmth, conscientiousness, and agreeableness
Authors: Imai Tatsuya 
Published: September 2023

AbstractThe literature suggests that expressed gratitude improves the interpersonal relationship between a beneficiary and a benefactor. However, there is little research that has explored why thanking provides these positive effects, so this study investigated thanking mechanisms to explain reasons why people feel close to a beneficiary who expresses gratitude. This study also examines the effects of apologies, which are sometimes used to show gratitude in Japan. In this experimental study, 671 Japanese participants reported their perceived closeness, warmth, conscientiousness, and agreeableness to a hypothetical beneficiary who expressed gratitude, apologies, or both after a benefit was provided. The results revealed that benefactors who received a message indicating gratitude and both gratitude and apologies reported higher levels of closeness toward a beneficiary than those who received a message with only apologies and a message without either gratitude or apologies. A structural equation model further indicated that warmth and conscientiousness mediated the link between expressed gratitude/apologies and perceived closeness.
Exact p‐value calculation for XCorr scoring of high‐resolution MS/MS data
Authors: Bhimani Kishankumar , Peresadina Arina , Vozniuk Dmitrii , Kertész‐Farkas Attila 
Published: September 2023

AbstractExact p‐value (XPV)‐based methods for dot product‐like score functions—such as the XCorr score implemented in Tide, SEQUEST, Comet or shared peak count‐based scoring in MSGF+ and ASPV—provide a fairly good calibration for peptide‐spectrum‐match (PSM) scoring in database searching‐based MS/MS spectrum data identification. Unfortunately, standard XPV methods, in practice, cannot handle high‐resolution fragmentation data produced by state‐of‐the‐art mass spectrometers because having smaller bins increases the number of fragment matches that are assigned to incorrect bins and scored improperly. In this article, we present an extension of the XPV method, called the high‐resolution exact p‐value (HR‐XPV) method, which can be used to calibrate PSM scores of high‐resolution MS/MS spectra obtained with dot product‐like scoring such as the XCorr. The HR‐XPV carries remainder masses throughout the fragmentation, allowing them to greatly increase the number of fragments that are properly assigned to the correct bin and, thus, taking advantage of high‐resolution data. Using four mass spectrometry data sets, our experimental results demonstrate that HR‐XPV produces well‐calibrated scores, which in turn results in more trusted spectrum annotations at any false discovery rate level.
A multicenter randomized, double‐blind, placebo‐controlled, parallel‐group study to evaluate the effects of a 1‐year regimen of orally inhaled fluticasone furoate 50 µg once daily on growth velocity in prepubertal, pediatric participants with well‐controlled asthma
Authors: Bareille Philippe , Imber Varsha , Crawford Jodie , Majorek‐Olechowska Bernadetta , Karam‐Absi Zeina , Stone Sally , Birk Ruby 
Published: September 2023

AbstractIntroduction: Growth impairment is a known adverse event (AE) of corticosteroids in children. This study aimed to assess the effect of once‐daily (QD) inhaled fluticasone furoate (FF) versus placebo on growth velocity over 1 year in prepubertal children with well‐controlled asthma.Materials and Methods: This randomized, double‐blind, parallel‐group, placebo‐controlled, multicenter study (NCT02889809) included prepubertal children, aged 5 to <9 years (boys), and 5 to <8 years (girls), with ≥6 months' asthma history. Children received inhaled placebo QD plus background open‐label montelukast QD for a 16‐week run‐in period and were then randomized 1:1 to receive inhaled FF 50 μg QD or placebo QD (whilst continuing background open‐label montelukast) for a 52‐week treatment period. The primary endpoint was the difference in growth velocity (cm/year) over the treatment period. Other growth endpoints were measured, as were incidence of AEs and asthma exacerbation. Growth analyses included all intent‐to‐treat (ITT) participants with ≥3 post‐randomization, on‐treatment clinic visit height assessments (GROWTH population).Results: Of 644 children in the run‐in period, 477 (mean age 6.2 years, 63% male) entered the 52‐week treatment period (ITT population: FF N = 238, placebo N = 239; GROWTH population: N = 457 [FF N = 231; placebo N = 226]). The least‐squares mean difference in growth velocity for FF versus placebo was –0.160 cm/year (95% confidence interval: –0.462, 0.142). There were no new safety signals.Conclusions: Over 1 year, FF 50 μg QD had a minimal effect on growth velocity versus placebo, with no new safety signals.
Association between SARS‐CoV‐2 viral kinetics and clinical score evolution in hospitalized patients
Authors: Néant Nadège , Lingas Guillaume , Gaymard Alexandre , Belhadi Drifa , Hites Maya , Staub Thérèse , Greil Richard , Paiva Jose‐Artur , Poissy Julien , Peiffer‐Smadja Nathan , Costagliola Dominique , Yazdanpanah Yazdan , Bouscambert‐Duchamp Maude , Gagneux‐Brunon Amandine , Ader Florence , Mentré France , Wallet Florent , Burdet Charles , Guedj Jérémie ,   the DisCoVeRy study group
Published: September 2023

AbstractThe role of antiviral treatment in coronavirus disease 2019 hospitalized patients is controversial. To address this question, we analyzed simultaneously nasopharyngeal viral load and the National Early Warning Score 2 (NEWS‐2) using an effect compartment model to relate viral dynamics and the evolution of clinical severity. The model is applied to 664 hospitalized patients included in the DisCoVeRy trial (NCT04315948; EudraCT 2020‐000936‐23) randomly assigned to either standard of care (SoC) or SoC + remdesivir. Then we use the model to simulate the impact of antiviral treatments on the time to clinical improvement, defined by a NEWS‐2 score lower than 3 (in patients with NEWS‐2 <7 at hospitalization) or 5 (in patients with NEWS‐2 ≥7 at hospitalization), distinguishing between patients with low or high viral load at hospitalization. The model can fit well the different observed patients trajectories, showing that clinical evolution is associated with viral dynamics, albeit with large interindividual variability. Remdesivir antiviral activity was 22% and 78% in patients with low or high viral loads, respectively, which is not sufficient to generate a meaningful effect on NEWS‐2. However, simulations predicted that antiviral activity greater than 99% could reduce by 2 days the time to clinical improvement in patients with high viral load, irrespective of the NEWS‐2 score at hospitalization, whereas no meaningful effect was predicted in patients with low viral loads. Our results demonstrate that time to clinical improvement is associated with time to viral clearance and that highly effective antiviral drugs could hasten clinical improvement in hospitalized patients with high viral loads.
Development of functional active films from blend of gelatin with crude orange juice pomace pectin: Test for packaging of virgin olive oil
Authors: Chentir Imene , Aribi Chouaib , Tarchoun Ahmed Fouzi , Kchaou Hela , Lamri Melisa , Nasri Moncef , Trache Djalal 
Published: September 2023

AbstractThe food packaging sector is focused on developing innovative materials to enhance food safety and quality while reducing environmental impact. Accordingly, this study aimed to develop packaging based on bovine gelatin (G) blended with crude sweet orange juice pomace pectin (SOPP) at different ratios (G/SOPP = 85/15, 65/35, 50/50, w/w). The obtained crude SOPP was highly methylated and exhibited antioxidant and antibacterial properties due to the presence of galacturonic acid (<70%) and phenolic compounds (58.2 ± 0.8 mg/g SOPP). High‐performance liquid chromatography with diode array detection analysis revealed the presence of hesperidin, catechin, and naringin as major phenolic compounds in SOPP. Further, the incorporation of this latter improved gelatin‐based packaging structural homogeneity, opacity, water vapour barrier features, glass transition temperature and tensile strength. G‐SOPP (50/50) film showed efficient antibacterial activity against Escherichia coli and Bacillus subtilis and high antioxidant potential reaching values of 0.7, 48.7%, 76.7% and 68.9% for reducing power, β‐carotene bleaching inhibition, DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) and ABTS+ (2,2′‐azinobis‐[3‐ethylbenzothiazoline‐6‐sulphonic acid]) radicals scavenging activities, respectively. Another interesting finding is that the combination of G and SOPP reduced the oil solubility of G‐SOPP films suggesting great physical integrity of the film over 63 days. The polyphenol content released from G‐SOPP blend film in a fatty simulant increased as SOPP content of films was increased. G‐SOPP (50/50) film, designed as a pouch, delays the photooxidation process of virgin olive oil over 63 days of storage time, without altering its organoleptic properties. Overall, these outstanding results highlighted the potential use of gelatin–pectin blend films for active packaging of oils and lipid‐based foods.
Immune checkpoint inhibitor‐induced asthma and chronic obstructive pulmonary disease overlap in patient with adenocarcinoma
Authors: Hayakawa Yuki , Kawaguchi Takako , Yamasaki Kei , Endo Miyu , Komatsu Masaya , Ishiguro Yutaka , Murata Yuichi , Yatera Kazuhiro 
Published: September 2023

AbstractA 67‐year‐old current smoker Japanese man, with no history of asthma, was diagnosed with lung adenocarcinoma. He received first‐line chemotherapy with carboplatin, pemetrexed, ipilimumab, and nivolumab in July 20XX‐1, and subsequently a maintenance therapy with nivolumab. In October 20XX, he became aware of wheezy dyspnoea, and chest computed tomography demonstrated worsening bronchial wall thickenings. Eosinophilia was noted, and a pulmonary function test showed obstructive dysfunction insufficiently responding to beta‐agonists, with 130 mL increase of forced expiratory volume in one second and high fractional exhaled nitric oxide level (85 ppb). He was clinically diagnosed with asthma and chronic obstructive pulmonary disease overlap, secondary to immune checkpoint inhibitors (ICIs). The inhibition of binding between programmed cell death‐protein‐1 (PD‐1), expressed on T cells, and programmed cell death‐ligand‐2 (PD‐L2), expressed on tumour and dendritic cells, can induce airway hyperresponsiveness. Physicians should be wary of asthmatic symptoms and chest image findings during ICIs therapy.
Robust fractional order singular Kalman filter
Authors: Nosrati Komeil , Belikov Juri , Tepljakov Aleksei , Petlenkov Eduard 
Published: September 2023

AbstractIn this article, the state estimation problem of linear fractional order singular (FOS) systems subject to matrix uncertainties is investigated where a recursive robust algorithm is derived. Considering an uncertain discrete‐time linear FOS system with added process and measurement noises, we aim to design a robust Kalman‐type state estimation algorithm based on an optimal data fitting approach with a given sequence of observations. As a substitute for the stochastic formulation, this general filter is obtained by minimizing a completely deterministic regularized residual norm in its worst‐possible form at each step over admissible uncertainties. Analysis of the algorithm shows that not only does the proposed robust filter cover the traditional robust Kalman filters (KFs), but it also represents an extension of the nominal fractional singular KF (FSKF) when the system is not subject to uncertainties. Furthermore, besides giving a sufficient condition for the existence of the robust filter, we derive conditions for the asymptotic properties of the filter, where we demonstrate that the filter and the Riccati equation are stable and converge when an equivalent system is detectable and stabilizable. A numerical example is included to demonstrate the performance of the introduced filter.
Continuous appointed‐time prescribed performance attitude tracking control for rigid spacecraft with actuator faults on SO(3)
Authors: Huang Qin , Zhang Ying 
Published: September 2023

AbstractIn this article, the attitude tracking problem for rigid spacecraft subject to external disturbance, inertia uncertainties, and actuator faults is investigated. A novel continuous control strategy is proposed to guarantee that the attitude tracking errors converge with desired performance before an appointed time. In addition, the proposed control law can enable the closed‐loop system to be unwinding‐free. For the purpose, a modified appointed‐time performance function (APF) is used to construct a disturbance observer‐based adaptive attitude control law based on the special orthogonal group (SO(3)). With the aid of the modified APFs, desired performance metrics, including transient and steady‐state performance, on the attitude tracking error can be specified in advance without the requirement for initial values of the tracking system to avoid singularity. By resorting to error transformation and backstepping technique, the control design process is simplified and a few control gains are involved in the proposed control law. Rigorous stability analysis based on the Lyapunov theory is provided to prove the appointed‐time stability of the attitude tracking error as well as the boundedness of all signals in the closed‐loop system despite external disturbance, inertia uncertainties, and actuator faults. Finally, numerical simulations are conducted to support the analysis.
Addressing institutional challenges in sustainable development goals implementation: Lessons from the Republic of Korea
Authors: Park Kyung Ryul , Park Young Shil 
Published: September 2023

AbstractWhy has the global norm of the sustainable development goals (SDGs) been facing challenges in the process of national implementation, even in developed countries? We conceptualize the implementation of the SDGs as a complex institutional process where a globally agreed norm is internalized into a specific context. Building on institutional theories, we conducted an interpretive case study of the Korean SDGs (K‐SDGs), focusing particularly on governance structure and differing stakeholders' engagement. The findings suggest that the notion of “sustainable development” has historically evolved with time in Korea, which has shaped the current implementation of the SDGs. The challenges in the process are not only technical and functional, but also socio‐institutional. These challenges include institutional fragmentation within the government, the inherent ambiguity of the SDGs, conflicting values, and interpretations of “sustainable development” in the Korean context. To address such challenges, the active participation of various stakeholders and collaborative governance were found to be significant, which in turn provides lessons for other countries.
Topical Cryogel Application of Carboxymethylcellulose/Silane‐Modified Hyaluronic Acid Containing Trachyspermum copticum Nanoemulsions for the Treatment of Infected Wounds
Authors: Zeinalpour Sajjad , Tabatabaei Zohreh Ghazi , Farahpour Mohammad Reza 
Published: September 2023

AbstractInfectious wounds commonly occur and must be rapidly treated with safe and efficient agents. Antibiotic‐resistant is a major challenge for the treatment of infected wounds. This preliminary study aimed to evaluate the effects of the topical cryogel application of carboxymethylcellulose/silane‐modified hyaluronic acid (CMC/HY‐Silane) containing Trachyspermum copticum essential oil nanoemulsions (TSP NEs) for the treatment of infected wounds. Four related factors of 3‐glycidyloxypropyl‐trimethoxysilane (GPTMS), time, pH and temperature were selected and their effects were evaluated to monitor the porosity each factor with the help of Taguchi method. The maximum porosity of cryogels (39.20 %) was obtained at GPTMS=30 μL, pH=9, temperature of 25 °C and time of 30 min. CMC/HY‐Silane hydrogels containing 0.00 %, 2.00 % and 4.00 % TSP NEs were produced. Antibacterial and toxicity of the nanostructures and wound contraction, total bacterial count, histopathological parameters and the expressions of IL‐10, TGF‐β1 and NF‐κB were also assessed. The efficiency of cryogels was compared with antibiotics. In vivo and in vitro studies confirmed that the administration of cryogels containing TSPNEs accelerated the wound healing process by increasing the expressions of collagen, IL‐10 and TGF‐β, fibroblast, epithelization and decreasing edema and the expression of NF‐κB. The results also showed that cryogels could compete with synthetic ointment of mupirocin.
Bionic Structural Coloration of Textiles Using the Synthetically Prepared Liquid Photonic Crystals
Authors: Li Xinyang , Wang Xiaohui , Wang Yanan , Hu Mingan , Liu Guojin , Chai Liqin , Zhou Lan , Shao Jianzhong , Li Yichen 
Published: September 2023

AbstractThe structural coloration of textiles with bionic photonic crystals (PCs) is expected to become a critical approach to the ecological coloration of textiles. Rapid and large‐area preparation of PC structurally colored textiles can be achieved via self‐assembly of high mass fractions of liquid photonic crystals (LPCs). However, the rapid and large‐scale manufacturing of LPCs remains a challenge. In this work, the pH regulator is added in the process of emulsion polymerization to solve the problem of phase transformation caused by the thermal decomposition of the initiator to produce H+, directly achieving 40 wt.% PS nanospheres in the dispersion. Then oligomers and small‐molecule salts are removed from the system via dialysis, and the pre‐crystallized LPC system is efficiently prepared. Adjusting the particle size and the mass fraction of nanospheres is shown to be an efficient way to control the optical properties of LPCs. The rapid and large‐area preparation of PC structural color fabric and the patterned PC structural color fabric with an iridescent effect is implemented by using LPCs as the assembly intermediate. By constructing the encapsulation layer on the surface of the PC structural color fabric, the consistency of high structural stability and high color saturation of the PC is realized.