bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermodynamic studies of a rotating polytropic black hole: Outer and interior regions
Authors: Haldar Amritendu , Haldar Anendu 
Published: March 2023

Abstract
In this letter, considering the metric of a rotating polytropic black hole in the Boyer-Lindquist coordinates, at first, we derive the thermodynamic parameters such as entropy S, Helmholtz free energy F, internal energy U and Gibbs free energy G and study its dependence on the outer horizon by depicting suitable graphs. Then after reconstruction of the metric of the same in the Eddington-Finkelstein coordinates, we establish the interior volume of the black hole. We further analyze the variations of the interior volume with the small change of the advanced time with respect to the radius. Here we show the existence of a certain value of the radius for which this variation becomes maximum. Moreover, we show the dependence of this maximum value of the radius on the mass of the black hole. We derive the differential form of the interior volume for this limit of the radius and hence the maximal interior volume of the said black hole. Finally, we analyze the same thermodynamic parameters inside the black hole and present a comparative study between the parameters in the outer and interior regions of the black hole.
Sleep Disturbances Across a Woman's Lifespan: What Is the Role of Reproductive Hormones?
Authors: Haufe Annika , Leeners Brigitte 
Published: March 2023

AbstractFluctuations of reproductive hormones are associated with various forms of sleep disturbances and specific sleep disorders, such as insomnia or sleep-disordered breathing, across different stages of reproductive aging. During the menstrual cycle, sleep is particularly disrupted during the late luteal phase, as demonstrated by both objective and subjective measurements of sleep. Progesterone and its metabolites generally have sleep-promoting effects. A steep decline in progesterone, for example, during the late luteal phase, is associated with sleep disruption. Endogenous estrogen shows no clear correlation with sleep alterations in relation to the menstrual cycle. During pregnancy, sleep disruption is not associated with changes in estrogen or progesterone but rather with changing physiological factors, such as nocturnal micturition, gastroesophageal reflux, or musculoskeletal discomfort, all substantial factors that most likely mask any effect of hormones. Both endogenous and exogenous estrogen, as well as progesterone, are positively associated with sleep during the menopausal transition. A marked improvement of sleep disturbances is observed with perimenopausal hormone therapy. As this effect is not seen in younger women receiving contraceptive therapy, other causes of sleep disturbances, such as aging and related changes in metabolism of stress hormones, secondary effects of vasomotor symptoms, or depression, must be considered. Gonadotropins are less associated with sleep disturbances than ovarian hormones, except for during the menopausal transition where follicle-stimulating hormone is related to sleep disruption. Further, hyperandrogenism, as seen in women with polycystic ovary syndrome, is associated with sleep disturbances and specific sleep disorders, for example, obstructive sleep apnea.
The Queerness of Character-Details
Authors: Bradway Teagan 
Published: March 2023

Abstract
This essay reconsiders the skepticism toward queer characters and the default privilege given to antirepresentational aesthetics in queer theory. To grasp the queer affordances of character, the essay identifies character-detail as an iconic and embodied dimension of character as an aesthetic form. Character-details beckon for queer uptake, or the recirculation of character-details into contexts, genres, and media to unlock new narrative trajectories for queerness. Character-details thus highlight the promiscuously queer relationality of character as an aesthetic form. The essay then turns to A. K. Summers’s graphic memoir, Pregnant Butch: Nine Long Months Spent in Drag (2014), which takes up the character-details of Tintin to expand the narration of gender nonconformity. Finally, the essay traces how character-details focalize bisexual queer eroticism in Carmen Maria Machado’s short story “Inventory” from Her Body and Other Parties (2017). Taken together, these texts exemplify the centrality of queer characters to—and character as an aesthetic form in—contemporary queer literature.
Breaking Up Evening Sitting with Resistance Activity Improves Postprandial Glycemic Response: A Randomized Crossover Study
Authors: GALE JENNIFER T. , WEI DOROTHY L. , HASZARD JILLIAN J. , BROWN RACHEL C. , TAYLOR RACHAEL W. , PEDDIE MEREDITH C. 
Published: March 2023

ABSTRACT

Introduction
Interrupting sedentary time during the day reduces postprandial glycemia (a risk factor for cardiometabolic disease). However, it is not known if benefits exist for postprandial glucose, insulin and triglyceride responses in the evening, and if these benefits differ by body mass index (BMI) category.

Methods
In a randomized crossover study, 30 participants (25.4 ± 5.4 yr old; BMI 18.5–24.9: n = 10, BMI 25–29.9: n = 10, BMI ≥30: n = 10) completed two intervention arms, beginning at ~1700 h: prolonged sitting for 4 h, and sitting with regular activity breaks of 3 min of resistance exercises every 30 min. Plasma glucose, insulin, and triglyceride concentrations were measured in response to two meals fed at baseline and 120 min. Four-hour incremental area under the curve was compared between interventions. Moderation by BMI status was explored.

Results
Overall, when compared with prolonged sitting, regular activity breaks lowered plasma glucose and insulin incremental area under the curve by 31.5% (95% confidence interval = −49.3% to −13.8%) and 26.6% (−39.6% to −9.9%), respectively. No significant differences were found for plasma triglyceride area under the curve. Interactions between BMI status and intervention was not statistically significant.

Conclusions
Interventions that interrupt sedentary time in the evening may improve cardiometabolic health by some magnitude in all participants regardless of bodyweight.
Competition and Collaboration on Fundraising for Short-Term Disaster Response: The Impact on Earmarking and Performance
Authors: Aflaki Arian , Pedraza-Martinez Alfonso J. 
Published: March 2023

Problem definition: Most humanitarian organizations (HOs) allow donors to earmark their donations (i.e., designate their contributions to a specific purpose). Allowing earmarking may increase donations; however, it creates operational inefficiencies that undermine the impact of those donations. Extant literature has mainly studied earmarking and its operational consequences in the absence of funding competition. We examine how competition for funding impacts earmarking decisions, fundraising costs, and HO performance in short-term disaster response. In addition to the competition model, we analyze two collaborative fundraising models: (i) full collaboration, where HOs contact donors as a unit and donors cannot donate to specific HOs on the fundraiser, and (ii) partial collaboration, where HOs contact donors as a unit and donors choose among the contacting HOs. Methodology: We use game theory to model the interactions between multiple HOs and a market of donors and build a multinomial logit model for the donor choice problem. Results: We find that competition for funding contributes to the prevalence of earmarked donations, increases fundraising costs, and hurts HO performance and utility. We show that two collaborative fundraising models can mitigate these issues depending on the availability of funding resources. When funding is abundant, full collaboration improves HO utility and reduces earmarking and fundraising costs. When funding is scarce, partial collaboration reduces fundraising costs and improves performance and HO utility. When funding is intermediate, these two forms of collaboration do not necessarily benefit HOs. Managerial implications: We illustrate how funding availability drives earmarking and fundraising decisions and key performance metrics of different funding models during short-term disaster response. Using data from the 2010 Haiti earthquake, our numerical study indicates that partial collaboration benefits response to disasters with funding shortage, whereas full collaboration suits disaster response with sufficient funding. HOs competing for funds can use our insights to improve their response effectiveness.Supplemental Material: The e-companion is available at https://doi.org/10.1287/msom.2023.1202 .
Nanosecond pulsed electric field ablates rabbit VX2 liver tumors in a non-thermal manner
Authors: Li Qing-Gang , Liu Zhen-Guo , Dong Gang , Sun Ying , Zou Ya-Wen , Chen Xiao-Long , Wu Bin , Chen Xin-Hua , Ren Zhi-Gang 
Published: March 2023

Background
Liver tumor remains an important cause of cancer-related death. Nanosecond pulsed electric fields (nsPEFs) are advantageous in the treatment of melanoma and pancreatic cancer, but their therapeutic application on liver tumors need to be further studied.

Methods
Hep3B cells were treated with nsPEFs. The biological behaviors of cells were detected by Cell Counting Kit-8, 5-ethynyl-20-deoxyuridine, and transmission electron microscopy (TEM) assays. In vivo, rabbit VX2 liver tumor models were ablated by ultrasound-guided nsPEFs and radiofrequency ablation (RFA). Contrast-enhanced ultrasound (CEUS) was used to evaluate the ablation effect. HE staining and Masson staining were used to evaluate the tissue morphology after ablation. Immunohistochemistry was performed to determine the expression of Ki67, proliferating cell nuclear antigen, and α-smooth muscle actin at different time points after ablation.

Results
The cell viability of Hep3B cells was continuously lower than that of the control group within 3 days after pulse treatment. The proliferation of Hep3B cells was significantly affected by nsPEFs. TEM showed that Hep3B cells underwent significant morphological changes after pulse treatment. In vivo, CEUS imaging showed that nsPEFs could completely ablate model rabbit VX2 liver tumors. After nsPEFs ablation, the area of tumor fibrosis and the expression of Ki67, proliferating cell nuclear antigen, and α-smooth muscle actin were decreased. However, after RFA, rabbit VX2 liver tumor tissue showed complete necrosis, but the expression of PCNA and α-smooth muscle actin did not decrease compared to the tumor group.

Conclusions
nsPEFs can induce Hep3B cells apoptosis and ablate rabbit VX2 liver tumors in a non-thermal manner versus RFA. The ultrasound contrast agent can monitor immediate effect of nsPEF ablation. This study provides a basis for the clinical study of nsPEFs ablation of liver cancer.
Metabolic, inflammatory and adipokine differences on overweight/obese children with and without metabolic syndrome: A cross-sectional study
Authors: Cura–Esquivel Idalia , Perales-Quintana Marlene Marisol , Torres-González Liliana , Guzmán-Avilán Katia , Muñoz-Espinosa Linda , Cordero-Pérez Paula 
Published: March 2023

Background
Obesity is associated with low-grade inflammation and metabolic syndrome (MetS) in both children and adults. Our aim was to describe metabolic, inflammatory and adipokine differences on overweight/obese children with and without MetS.

Methods
This was an observational study. A total of 107 children and adolescents aged 6–18 years were included. Among this sample, n = 21 had normal body weight, n = 22 had overweight/obesity without MetS, and n = 64 had overweight/obesity with MetS. Anthropometric data and biochemical, adipokine, and inflammatory markers were measured. Different ratios were then assessed for estimate the probability of MetS. ROC analysis was used to estimate the diagnostic accuracy and optimal cutoff points for ratios.

Results
Serum CRP levels were higher among children with overweight/obesity with MetS. Adipokines like PAI-1 and leptin were significantly lower in children with normal body weight. The Adipo/Lep ratio was highest in the group with normal body weight. TG/HDL-C and TC/HDL-C ratios were significantly correlated with BMI, DBP, PCR, and PAI-1. TC/HDL-C ratio was significantly correlated with SBP and resistin. TGL/HDL-C ratio was significantly correlated with waist and hip circumferences, fasting glucose, and MCP-1. The AUC for TG/HDL-C at the optimal cutoff of 2.39 showed 85.71% sensitivity and 71.43% specificity. CT/HDL-C at the optimal cutoff of 3.70 showed 65.08% sensitivity and 81.82% specificity. Levels of both ratios increased significantly as additional MetS criteria were fulfilled.

Conclusion
Low-grade inflammation is correlated with MetS in children with overweight/obesity. TGL, HDL-C and TGL/HDL-C ratio, obtainable from routine lab tests, allows identification of MetS in children with overweight or obesity.
Negative and positive self-beliefs in social anxiety: The strength of believing mediates the affective response
Authors: Golde Sabrina , Ludwig Sophie , Lippoldt Sven , Rimpel Jérôme , Schulze Lars , Haucke Matthias , Renneberg Babette , Heinzel Stephan 
Published: March 2023

Background and objectives
Current cognitive models of social anxiety disorder (SAD) propose that individual, situation-specific self-beliefs are central to SAD. However, the role of differences in the degree to which individuals with social anxiety are convinced of self-beliefs, in particular positive ones, is still not fully understood. We compared how much high and low socially anxious individuals agree with their own negative and positive self-beliefs. Furthermore, we investigated whether agreeing with one’s self-belief can explain the relation between negative affect in response to self-beliefs and social anxiety. Specifically, we were interested whether social anxiety increases negative affect in response to self-beliefs through an increase in agreement.

Methods
We developed a new experimental self-belief task containing positive and negative semi-idiosyncratic, situation specific self-beliefs typical of high social anxiety and included a direct measure of agreement with these beliefs. Using extreme group sampling, we a-priori selected high (n = 51) and low (n = 50) socially anxious individuals. By multi-level mediation analysis, we analyzed agreement with self-beliefs in both groups and its association with affect.

Results
High and low socially anxious individuals chose similar self-beliefs. However, high socially anxious individuals (HSA) agreed more with negative self-beliefs and less with positive self-beliefs compared to low socially anxious individuals (LSA). HSA individuals reported increased negative affect after both, exposition to negative and positive self-beliefs compared to LSA. We found that social anxiety increases affective responses towards negative-self beliefs through an increase in agreeing with these self-beliefs.

Conclusions
These findings suggest that cognitive models of social anxiety can be improved by including not only the content of a self-belief but also the strength of such a belief. In addition, they emphasize the relevance of positive self-beliefs in social anxiety, which has frequently been overlooked.
Conversion to belatacept after lung transplantation: Report of 10 cases
Authors: Brugière Olivier , Vallée Alexandre , Raimbourg Quentin , Peraldi Marie-Noelle , de Verdière Sylvie Colin , Beaumont Laurence , Hamid Abdulmonem , Zrounba Mathilde , Roux Antoine , Picard Clément , Parquin François , Glorion Matthieu , Oniszczuk Julie , Hertig Alexandre , Mal Hervé , Bunel Vincent 
Published: March 2023

BackgroundCalcineurin inhibitors (CNIs) remain the cornerstone of maintenance immunosuppression (IS) after lung transplantation (LTx), although CNI-related life-threatening toxic effects may occur. Belatacept, a novel immunosuppressant that blocks a T-cell co-stimulation pathway, is a non-nephrotoxic drug indicated as an alternative to CNIs in kidney Tx. In LTx, there are only a few reports of belatacept conversion as a CNI-free or CNI-sparing IS treatment.MethodsWe reviewed a series of 10 LTx recipients with conversion to a CNI-free belatacept IS regimen within the first year post-LTx (n = 7) or a belatacept/low-dose CNI combination after the first year (n = 3).ResultsUse of belatacept was triggered by severe renal failure in 9 patients and under-IS with previous other IS-related toxicities in 1 patient. Mean estimated glomerular filtration rate after starting belatacept significantly improved at 6 months after initiation and at the last-follow-up (p = 0.006, and p = 0.002 respectively). The incidence of recurrent and/or severe acute cellular rejection (ACR) episodes was high in patients with CNI-free belatacept-based IS (n = 4/7). Chronic graft allograft dysfunction developed in 2 of 9 recipients under belatacept IS. Belatacept was stopped in 6 patients because of recurrent/severe ACR (n = 3), recurrent opportunistic infections (n = 1), center modified policy (n = 1), or other cause (n = 1).ConclusionEarly conversion to CNI-free belatacept-based IS improved renal function in this series but was counterbalanced by a high incidence of recurrent ACR, including life-threatening episodes. Other studies are needed to better determine the indications for its use after LTx, possibly with lower immunological risk IS regimens, such as CNI-sparing belatacept.
Progress in scale up of HIV viral load testing in select sub-Saharan African countries 2016–2018
Authors: Fonjungo Peter N. , Lecher Shirley , Zeh Clement , Rottinghaus Erin , Chun Helen , Adje-Toure Christiane , Lloyd Spencer , Mwangi Jane W. , Mwasekaga Michael , Eshete Yohannes Mengistu , Pati Rituparna , Mots’oane Tsietso , Mitruka Kiren , Beukes Anita , Mwangi Christina , Bowen Nancy , Hamunime Ndapewa , Beard Rachel S. , Kabuje Anyelwisye , Nabadda Susan , Auld Andrew F. , Balachandra Shirish , Zungu Innocent , Kandulu James , Alemnji George , Ehui Eboi , Alexander Heather , Ellenberger Dennis 
Published: March 2023

Introduction
We assessed progress in HIV viral load (VL) scale up across seven sub-Saharan African (SSA) countries and discussed challenges and strategies for improving VL coverage among patients on anti-retroviral therapy (ART).

Methods
A retrospective review of VL testing was conducted in Côte d’Ivoire, Kenya, Lesotho, Malawi, Namibia, Tanzania, and Uganda from January 2016 through June 2018. Data were collected and included the cumulative number of ART patients, number of patients with ≥ 1 VL test result (within the preceding 12 months), the percent of VL test results indicating viral suppression, and the mean turnaround time for VL testing.

Results
Between 2016 and 2018, the proportion of PLHIV on ART in all 7 countries increased (range 5.7%–50.2%). During the same time period, the cumulative number of patients with one or more VL test increased from 22,996 to 917,980. Overall, viral suppression rates exceeded 85% for all countries except for Côte d’Ivoire at 78% by June 2018. Reported turnaround times for VL testing results improved in 5 out of 7 countries by between 5.4 days and 27.5 days.

Conclusions
These data demonstrate that remarkable progress has been made in the scale-up of HIV VL testing in the seven SSA countries.
Implementation and outcomes of a comprehensive emergency care curriculum at a low-resource referral hospital in Liberia: A novel approach to application of the WHO Basic Emergency Care toolkit
Authors: Epps Lane , Ramachandran Anu , Yi Sojung , Mayah Alexander , Burkholder Taylor , Jaung Michael , Haider Ahson , Wesseh Paul , Shakpeh John , Bills Corey , Enriquez Kayla 
Published: March 2023

Background
Emergency care is vital in low- and middle-income countries (LMICs) but many frontline healthcare workers in low-resource settings have no formal training in emergency care. To address this gap, the World Health Organization (WHO) developed Basic Emergency Care (BEC): Approach to the acutely ill and injured, a multi-day, open-source course for healthcare workers in low-resource settings. Building on the BEC foundation, this study uses an implementation science (IS) lens to develop, implement, and evaluate a comprehensive emergency care curriculum in a single emergency facility in Liberia.

Methods
A six-month emergency care curriculum consisting of BEC content, standardized WHO clinical documentation forms, African Federation of Emergency Medicine (AFEM) didactics, and clinical mentorship by visiting emergency medicine (EM) faculty was designed and implemented using IS frameworks at Redemption Hospital, a low-resource public referral hospital in Monrovia, the capital of Liberia. Healthcare worker performance on validated knowledge-based exams during pre- and post-intervention testing, post-course surveys, and patient outcomes were used to evaluate the program.

Results
Nine visiting EM physicians provided 1400 hours of clinical mentorship and 560 hours of didactic training to fifty-six Redemption Hospital staff over six-months. Median test scores improved 20.0% (p<0.001) among the forty-three healthcare workers who took both the pre- and post-intervention tests. Participants reported increased confidence in caring for medical and trauma patients and comfort performing emergency care tasks on post-course surveys. Emergency unit (EU)/Isolation unit (IU) mortality decreased during the six-month implementation period, albeit non-significantly. Course satisfaction was high across multiple domains.

Discussion
This study builds on prior research supporting WHO efforts to improve emergency care globally. BEC implementation over a six-month timeframe using IS principles is an effective alternative strategy for facilities in resource-constrained environments wishing to strengthen emergency care delivery.