bluuebunny/crossref_metadata_2025_split huggingface dataset:
Composite tissue xenopreservation: Preliminary results of staged VCA in rat to mouse model
Authors: Zor Fatih , Kapaj Rezarta , Kulahci Yalcin , Karslioglu Yildirim , Gorantla Vijay S. 
Published: June 2023

AbstractBackgroundThe time between procurement and transplantation of composite tissues, especially regarding the limited donor pool, is a challenge effecting the outcomes of the transplantation. Current preservation techniques mainly include either cold preservation with a solution or machine perfusion using blood or certain oxygen‐carrying solutions. However, none enables preservation beyond 24 h. Increasing this time to several days will provide better usage of the donor pool, safer transplantation of VCA with significant muscle content, and gives time to stabilize a patient before long surgical procedures. Herein, we described a novel strategy of xenopreservation (preservation via xenotransplantation) to preserve composite tissues for 7 days, followed by staged transplantation.Materials and MethodsWe used two concordant species, female Sprague Dawley rats (n = 10) and female CF‐1 mice (n = 10) in this study. Four of pair of animals are used for anatomical study. The groin flap of the rat was used as a xenograft and xenotransplanted to the neck area of the carrier mouse. Cyclosporine (CsA) was administered used as immunosuppressant. After 7 days of preservation on the mouse neck, xenotransplanted groin flap (called xenopreserved flap) was re‐harvested, skin and vessels samples were collected for histopathological evaluation, and the xenopreserved flap was transplanted to the donor rat's opposite groin area. Anastomoses were performed between the flap's pedicle and the femoral vessels. Clinical observation regarding inflammation and tissue perfusion of the xenopreserved flap was monitored daily. Fifteen days after the second surgical procedure, the rats were euthanized, and skin and vessel samples were collected. Histologic evaluation, including inflammatory cell numbers, was performed. Wilcoxon test was used to compare the changes in inflammation severity and p < .05 was set for statistical significance.ResultsAll xenopreserved groin flaps except one survived. Mean lymphocyte count before the second operation (at the end of the xenopreservation procedure) was 20,22 ± 0.44 and reduced to 13,14 ± 0.47 at the end of 15 days, and the difference was statistically significant (p < .05).ConclusionThis proof‐of‐concept study with preliminary results showed that xenotransplantation might be a novel strategy for preservation of VCA for a certain period of time. However, additional translational studies are needed to modulate the tissue changes following xenopreservation.
Mathematical modelling of the mechanical response of geosynthetic‐reinforced and pile‐supported embankments
Authors: Mangraviti Viviana , Flessati Luca , di Prisco Claudio 
Published: June 2023

AbstractPiled foundations are commonly employed to reduce settlements in artificial earth embankments founded on soft soil strata. To limit the number of piles and, consequently, construction costs, popular is the use of geosynthetic reinforcements laid at the embankment base. Nowadays, the complex interaction between geosynthetics, piles and soil is not yet fully understood and, in the scientific literature, simplified displacement‐based approaches to choose reinforcements, pile diameter and spacing are missing. In this paper, the authors, starting from the critical analysis and theoretical interpretation of finite difference numerical results, introduce a new mathematical model to rapidly assess both (i) differential/average settlements at the top of the embankment and (ii) maximum tensile forces in the basal reinforcement. The model, conceived to reproduce the response of a pile belonging to the central part of the embankment, is the result of an upscaling procedure based on a suitable sub‐structuring of the spatial domain (an axisymmetric unit cell) and on the concept of plane of equal settlements. For the foundation soil, drained conditions are considered, the pile skin roughness is disregarded, and piles are assumed to get the rigid bedrock. As generalised kinematic variables average and differential settlements are employed, whereas as generalized static ones the embankment height and the geosynthetic axial force. The model is validated against field measurements (where layered foundation soil and pile caps are included) and an application example of the model, used as a preliminary design tool in a displacement‐based perspective, is finally provided.
Unsafe doctor–nurse interactions in the process of implementing medical orders: A qualitative study
Authors: Asadi Monireh , Ahmadi Fazlollah , Mohammadi Easa , Vaismoradi Mojtaba 
Published: June 2023

AbstractAimThis study aimed to explore challenges faced by clinical nurses in the process of implementing medical orders.DesignA qualitative study using inductive content analysis.MethodsSemi‐structured individual interviews were carried out with 17 participants including nurses, nurse managers and medical doctors who were purposefully selected. The collected data underwent inductive qualitative content analysis.ResultsThe main research finding was the category of ‘unsafe doctor–nurse interaction’. It included three subcategories: ‘conflicts in documenting and executing orders’, ‘not accepting the nurse's suggestions for writing and correcting orders’ and ‘failure to accept the responsibility of orders by the doctor’. Challenges in the professional relationship between doctors and nurses cause mistrust and conflict. They also enhance nurses' concerns about professional and legal issues in the workplace and endanger patient safety.
Association between disordered eating and clinical outcomes following a surgical or endoscopic bariatric procedure: A real‐world exploratory study
Authors: Spry Georgia , McIntosh Ashleigh , Gadd Nicola , Martin Zoe , Fear‐Keen Brianna , Hoult Jennifer , Maimone Isabella R. , Jones Patrice , Kelly Jaimon T , Marshall Skye 
Published: June 2023

AbstractProblemDisordered eating, such as binge, graze, and emotional eating, has been strongly linked to weight gain. Improved understanding of disordered eating by adults who elect bariatric weight loss procedures in a real‐world setting is required.PurposeTo determine the association between the number and type of disordered eating patterns (DEPs), as described by healthcare professionals during routine care without standardized assessment, with clinical outcomes in adults who elected a bariatric weight loss procedure.MethodAn observational cohort study recruited laparoscopic sleeve gastrectomy (LSG) and endoscopic sleeve gastroplasty (ESG) patients. DEPs documented in the medical record during routine care were observed and tested for association with events (symptoms, side‐effects, or adverse events), micronutrient deficiencies, weight loss, and attrition. Data were observed up to 12‐month post‐procedure.Results215 LSG and 32 ESG patients were recruited. The mean number of DEPs was 6.4 (SD: 2.1) and 6.4 (SD: 2.1) in the LSG and ESG cohorts, respectively. Night eating was associated with a higher number of events (p < 0.008) in the LSG cohort, and non‐hungry eating was associated with a higher number of events in the ESG cohort (p < 0.001). ESG patients who had a surgical or medical event by 6‐months post‐procedure had mean 1.78 (95%CI: 0.67, 2.89) more DEPs (p = 0.004). DEPs were not associated with weight loss, micronutrient deficiencies, nor attrition.ConclusionThe treating healthcare team believed the LSG and ESG patients experienced a wide variety and high frequency of DEPs requiring multidisciplinary support. Non‐hungry eating and night eating were associated with poorer outcomes following an LSG or ESG.Trial registrationThe study was prospectively registered with the Australian New Zealand Clinical Trials Registry (ACTRN12622000332729).
Biocomposites based on poly(lactic acid)/Aloe Vera/Priplast. Effects of UVA radiation on the crystallization
Authors: Nicácio Pedro , Albuquerque Ananda , Dantas Lorena , Siqueira Danilo , Ries Andreas , Wellen Renate 
Published: June 2023

AbstractBiocomposites based on poly(lactic acid) (PLA), Aloe Vera (AV), and Priplast (Pr), were produced with AV and Pr levels of 5% and 10%, and submitted to UVA radiation for a time interval up to 28 days. Chemical changes were investigated using Fourier transform infrared spectroscopy (FTIR) and the thermal behavior was elucidated using differential scanning calorimetry (DSC); the non‐isothermal crystallization kinetics was modeled using the Pseudo‐Avrami model. FTIR spectra evidenced the formation of chromophore groups resulting from the photodegradation, which it was less intense in biocomposites with 10% Pr. AV addition promoted the cold crystallization, whereas the crystallization rate () displayed higher values for PLA/10%AV, with slight increases in the degree of crystallinity (Xc); while Pr addition decreased the Xc and of PLA, and protected it more intensely against the photodegradation effects. Pseudo‐Avrami model presented R2 ≥ 0.9909 and a low discrepancy between experimental and theoretical data, being adequate to describe the cold crystallization of PLA biocomposites. Summing up, AV and Pr addition protect PLA against the harmful effects of photodegradation, with AV subtly interfering in the crystalline parameters while Pr provides greater amorphicity to PLA biocomposites.
Defining the first bona fide cell model for SMARCA4‐deficient, undifferentiated tumor
Authors: Arenas Alberto M , Ruiz‐Jiménez José Manuel , López‐Hidalgo Javier L , Sanjuán‐Hidalgo Juan , Medina Pedro P 
Published: June 2023

AbstractThe World Health Organization's tumor classification guidelines are frequently updated and renewed as knowledge of cancer biology advances. For instance, in 2021, a novel lung tumor subtype named SMARCA4‐deficient, undifferentiated tumor (SMARCA4‐dUT, code 8044/3) was included. To date, there is no defined cell model for SMARCA4‐dUT that could be used to help thoracic clinicians and researchers in the study of this newly defined tumor type. As this tumor type was recently described, it is feasible that some cell models formerly classified as lung adenocarcinoma (LUAD) could now be better classified as SMARCA4‐dUT. Thus, in this work, we aimed to identify a bona fide cell model for the experimental study of SMARCA4‐dUT. We compared the differential expression profiles of 36 LUAD‐annotated cell lines and 38 cell lines defined as rhabdoid in repositories. These comparative results were integrated with the mutation and expression profiles of the SWI/SNF complex members, and they were surveyed for the presence of the SMARCA4‐dUT markers SOX2, SALL4, and CD34, measured by RT‐qPCR and western blotting. Finally, the cell line with the paradigmatic SMARCA4‐dUT markers was engrafted into immunocompromised mice to assess the histological morphology of the formed tumors and compare them with those formed by a bona fide LUAD cancer cell line. NCI‐H522, formerly classified as LUAD, displayed expression profiles nearer to rhabdoid tumors than LUAD tumors. Furthermore, NCI‐H522 has most of the paradigmatic features of SMARCA4‐dUT: hemizygous inactivating mutation of SMARCA4, severe SMARCA2 downregulation, and high‐level expression of stem cell markers SOX2 and SALL4. In addition, the engrafted tumors of NCI‐H522 did not display a typical differentiated glandular structure as other bona fide LUAD cell lines (A549) do but had rather a largely undifferentiated morphology, characteristic of SMARCA4‐dUT. Thus, we propose the NCI‐H522 as the first bona fide cell line model of SMARCA4‐dUT. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Clinical features and outcome of retinoblastoma at the Vietnam National Cancer Hospital
Authors: Do Kien Hung , Pham Chau T. Minh , Do Thanh C. , Hoang Trang T. , Hoang Tuan A. , Nguyen Chu V. , Bui Giang V. , Ngo Lam L. , Van Nguyen Tai , Le Quang V. 
Published: June 2023

AbstractObjectivesTo characterize the clinical features, treatment, and outcome of children diagnosed with retinoblastoma (RB) at Vietnam National Cancer Hospital.MethodsThe study enrolled all RB patients newly diagnosed at Vietnam National Cancer Hospital from January 2018 to December 2022. The primary endpoint was overall survival (OS) and the eye salvage rate.ResultsIn total, 139 patients were enrolled, 51.8% patients were male. Median age was 18.9 months. Most patients presented with leukocoria (63.3%), followed by strabismus (14.4%), and 43.9% had bilateral disease. Of 200 eyes, 129 (64.5%) were classified as group E. Extraocular extension was noted in 10 of 139 patients (7.2%). About one‐third of the patients lived more than 300 kilometers (km) away from these hospitals, and 17.3% of the patients belonged to minority groups, both of which were dominated by group E and extraocular or high‐risk eyes at the time of consultation. Primary enucleation was done for 57 eyes (28.5%), and 51 of 61 patients (83.6%) received eye salvage therapy in bilateral RB group. At study closure, 127 children were alive at the last follow‐up, 12 cases were confirmed dead. The 5‐year OS and progression‐free survival (PFS) rates were 90.3% and 85.9%, respectively. In particular, ethnic minority, distance to hospital more than 150 km, and extraocular disease were significantly associated with higher mortality among children with RB treated in Vietnam National Cancer Hospital.ConclusionsThere is a need to support for screening RB with early symptoms in grassroots medical facilities and raise awareness among patients' families through health education programs. Besides, caring and supporting treatment for patients from the ethnic minority and who live far from hospitals are also extremely necessary.
Effect of triaxial woven fabric on bending properties of unidirectional composites
Authors: Li Zhe , Li Wei 
Published: June 2023

AbstractThis study investigates the impact of incorporating a triaxial woven fabric (TWF) into a unidirectional ply structure on the bending performance of the structure. The failure processes of the different ply structures were recorded using video analysis and acoustic emission. The experimental results indicated that incorporating a layer of carbon fiber TWF between the second and third layers (GGTGG) or between the third and fourth layers (GGGTG) of the four‐layer unidirectional fabric significantly improved the flexural strengths by 79.5% and 213.7%, respectively, and the flexural toughness by 480.3% and 324.8%, respectively. In addition, the incorporation of TWF in the structure resulted in a shift in the overall failure mode from brittle to ductile. When the TWF was closer to the lower surface of the sample, the crack was more uniform and the distribution range was wider. In contrast when the TWF was in the middle, the range of cracks generated by the sample was narrower. However, some of these cracks affected the stability of the material structure. Furthermore, the damage process was confirmed using images of crack growth and acoustic emission during the destruction process. This study provides valuable insights into enhancing the bending performance of unidirectional fiber layup in the non‐load direction.
Study of the dynamic fragility of polymer nanocomposites: Correlation with damping
Authors: Charitos Ilias , Kontou Evagelia 
Published: June 2023

AbstractIn this work, an extensive study on the glass transition temperature (Tg), dynamic fragility and activation energy (Ea) for a variety polymeric nanocomposite materials, based on four different types of polymeric matrices reinforced with carbonaceous nanofillers, and SiO2 has been performed. Referring to the dynamic mechanical analysis data obtained in the author's previous works, the dynamic fragility and activation energy were calculated and examined. Depending on the polymeric type, different behavior was detected, as far as the fragility dependence on nanofiller type and loading is concerned, whereas the Tg variation was also investigated. A general trend of a decreasing dynamic fragility with increasing Tg was found, with the exception of Polylactic acid (PLA)/hybrid nanocomposites. A relation between nanofillers synergy and dynamic fragility variation has been achieved, namely the more homogenous nanofillers dispersion (and the synergistic effect between nanofillers), was associated with higher dynamic fragility values. Furthermore, the inter‐particle distance increment may lead to an increased fragility and the Resin/SiO2 nanocomposites appear to follow this rule. In addition, strain sweep experiments were conducted to analyze the connection between fragility and damping of the polymer nanocomposites. The PLA/hybrid carbonaceous nanocomposites reveal an essential damping enhancement, associated with fragility lowering.
Enhanced thermal properties of HDPE/EG nanocomposites via synergy of multi‐source pulsating flow and phase transition
Authors: Yin Xiaochun , Jiang Jinjin , He Guangjian , Feng Yanhong , Zhang Guizhen 
Published: June 2023

AbstractA new melt mixing and in‐situ exfoliation method based on the synergy of multi‐source pulsating flow and phase transition (MSPFPT) was reported. The corresponding device was also developed, and the structure and mixing process of the mixer were introduced in detail. High‐density polyethylene (HDPE)/expanded graphite (EG) composites were prepared via this new mixer, and microstructure and thermal properties of the composites were comprehensively investigated. Morphological analyses demonstrate that MSPFPT method promotes the efficient exfoliation and uniform dispersion of EG. The well‐exfoliated EG layers form more thermal conductive paths in the composites prepared by MSPFPT, increasing thermal conductivity from 0.47 of pure HDPE to 1.16 W/(m·K) with 9 wt.% EG. The crystallinity degree of HDPE is increased by 11.1%. The increment of crystallinity reduces phonon scattering, which further confirms that MSPFPT method can significantly improve the thermal performance. The research provides a practical strategy for fabricating high‐performance composites filled with layered fillers.
Quality assessment method for Chinpi, dried Citrus spp. peel and its derived Kampo medicines using specific monoclonal antibody against hesperidin
Authors: Noguchi Kanta , Imahori Daisuke , Kido Yusuke , Nuntawong Poomraphie , Tanaka Hiroyuki , Morimoto Satoshi , Sakamoto Seiichi 
Published: June 2023

AbstractIntroductionHesperidin (hesperetin 7‐rutinoside, HP), a flavonoid glycoside found in Citrus unshiu Marcowicz or Citrus reticulata Blanco (Rutaceae), has been reported to exert a variety of pharmacological effects. As the efficacies and qualities of their dried peel, Chinpi and its derived Kampo medicines can be evaluated by their HP contents, a method for HP detection must be developed.ObjectivesTo produce a specific monoclonal antibody against HP (mAb 5D12) to detect the HP contents in Japanese traditional medicines via indirect competitive enzyme‐linked immunosorbent assay (icELISA).MethodBALB/c mice were immunised with many haptens of HP–bovine serum albumin (BSA) conjugates that were prepared using sodium periodate (NaIO4) to cause an immune response. In addition, conventional hybridoma techniques were utilised to generate mAb 5D12.ResultsThe detection range of HP by the mAb 5D12‐based icELISA was 1.56–25.0 ng/mL, with a detection limit of 1.12 ng/mL. The maximum coefficient of variation, as evaluated from the intra‐ and inter‐assays, was <10.0%, and the percentages of recovery, as determined by the spike‐recovery tests, were 105%–115%. Moreover, the HP content, which was obtained from the developed icELISA, correlated well with that obtained via high‐performance liquid chromatography–ultraviolet (HPLC‐UV).ConclusionThese validation analyses revealed that the established icELISA technique exhibited high precision and accuracy. Notably, this is the first report on the development of icELISA for the HP content‐based quality control of Chinpi and its derived Kampo medicines.
Synthesis of hydroxyl silane coupling agent and its application in preparation of silane‐modified polyurethane
Authors: Guo Zhiqiang , Shangguan Huimin , Liu Qianwei , Li Yinhe , Liu Xingjiang , Sun Ailing , Li Yuhan , Wei Liuhe 
Published: June 2023

AbstractThis study describes the synthesis of a hydroxyl silane coupling agent (HO‐silane) through a click reaction between SH in 3‐(trimethoxysilyl)propane‐1‐thiol (KH‐590) and CC in 2‐hydroxyethyl methacrylate (HEMA). This coupling agent was subsequently employed in the synthesis of silane‐modified polyurethane (SPU) resin which could be moisture‐cured at room temperature. The influence of r values (the molar ratio of NCO and OH) on the characteristics of SPU resins was investigated. These results reveal that an increase in the r value leads to a reduction in viscosity from 4.9 × 105 to 1.9 × 105 mPa·s, a rise in tensile strength from 0.88 to 0.98 Mpa followed by a decline to 0.69 MPa, and a reduction in extension at fracture from 236% to 94%. A SPU resin with a viscosity of approximately 3.6 × 105 mPa·s, tensile strength of 0.98 MPa, and elongation at break of 218% can be produced when the r value is 1.8. In addition, a silane‐modified polyurethane (MS) sealant with a tensile strength of 1.6 MPa in addition to elongation at break at 336% could be produced using the aforementioned SPU resin.
Telehealth in PM&R: Past, present, and future in clinical practice and opportunities for translational research
Authors: Tenforde Adam S. , Alexander Joshua J. , Alexander Marcalee , Annaswamy Thiru M. , Carr Conley J. , Chang Philip , Díaz Monique , Iaccarino Mary A. , Lewis Stephen B. , Millett Carolyn , Pandit Sindhu , Ramirez Claudia P. , Rinaldi Robert , Roop Megan , Slocum Chloe S. , Tekmyster Gene , Venesy Deborah , Verduzco‐Gutierrez Monica , Zorowitz Richard D. , Rowland Todd R. 
Published: June 2023

AbstractTelehealth refers to the use of telecommunication devices and other forms of technology to provide services outside of the traditional in‐person health care delivery system. Growth in the use of telehealth creates new challenges and opportunities for implementation in clinical practice. The American Academy of Physical Medicine and Rehabilitation (AAPM&R) assembled an expert group to develop a white paper to examine telehealth innovation in Physical Medicine and Rehabilitation (PM&R). The resultant white paper summarizes how telehealth is best used in the field of PM&R while highlighting current knowledge deficits and technological limitations. The report identifies new and transformative opportunities for PM&R to advance translational research related to telehealth and enhance patient care.