bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and biomarker factors affecting survival in patients with platinum-sensitive relapsed ovarian cancer receiving olaparib monotherapy: a multicenter retrospective study
Authors: Tashiro Ryota , Kawazoe Hitoshi , Mamishin Kanako , Seto Keisuke , Udagawa Ryoko , Saito Yoshimasa , Hashimoto Hironobu , Shimoi Tatsunori , Yonemori Kan , Yonemura Masahito , Terakado Hiroyuki , Nishimura Takahiro , Kawasaki Toshikatsu , Furukawa Tetsuya , Nakamura Tomonori 
Published: July 2023

AbstractThe standard treatment for platinum-sensitive relapsed ovarian cancer (PSROC) is platinum-based chemotherapy followed by olaparib monotherapy. A retrospective study was conducted to identify factors affecting the survival of patients with PSROC undergoing olaparib monotherapy in real-world clinical settings. The study enrolled 122 patients who received olaparib monotherapy between April 2018 and December 2020 at three national centers in Japan. The study used the Kaplan–Meier method and univariable and multivariable Cox proportional hazards models to evaluate the associations between factors and progression-free survival (PFS). Patients with BRCA1/2 mutations had a significantly longer median PFS than those without these mutations. Both the BRCA1/2 mutation-positive and mutation-negative groups exhibited a prolonged PFS when the platinum-free interval (PFI) was ≥ 12 months. Cancer antigen 125 (CA-125) level within reference values was significantly linked to prolonged PFS, while a high platelet-to-lymphocyte ratio (≥ 210) was significantly associated with poor PFS in the BRCA1/2 mutation-negative group. The study suggests that a PFI of ≥ 12 months may predict survival after olaparib monotherapy in patients with PSROC, regardless of their BRCA1/2 mutation status. Additionally, a CA-125 level within reference values may be associated with extended survival in patients without BRCA1/2 mutations. A larger prospective study should confirm these findings.
Deep learning predicts patients outcome and mutations from digitized histology slides in gastrointestinal stromal tumor
Authors: Fu Yu , Karanian Marie , Perret Raul , Camara Axel , Le Loarer François , Jean-Denis Myriam , Hostein Isabelle , Michot Audrey , Ducimetiere Françoise , Giraud Antoine , Courreges Jean-Baptiste , Courtet Kevin , Laizet Yech’an , Bendjebbar Etienne , Du Terrail Jean Ogier , Schmauch Benoit , Maussion Charles , Blay Jean-Yves , Italiano Antoine , Coindre Jean-Michel 
Published: July 2023

AbstractRisk assessment of gastrointestinal stromal tumor (GIST) according to the AFIP/Miettinen classification and mutational profiling are major tools for patient management. However, the AFIP/Miettinen classification depends heavily on mitotic counts, which is laborious and sometimes inconsistent between pathologists. It has also been shown to be imperfect in stratifying patients. Molecular testing is costly and time-consuming, therefore, not systematically performed in all countries. New methods to improve risk and molecular predictions are hence crucial to improve the tailoring of adjuvant therapy. We have built deep learning (DL) models on digitized HES-stained whole slide images (WSI) to predict patients’ outcome and mutations. Models were trained with a cohort of 1233 GIST and validated on an independent cohort of 286 GIST. DL models yielded comparable results to the Miettinen classification for relapse-free-survival prediction in localized GIST without adjuvant Imatinib (C-index=0.83 in cross-validation and 0.72 for independent testing). DL splitted Miettinen intermediate risk GIST into high/low-risk groups (p value = 0.002 in the training set and p value = 0.29 in the testing set). DL models achieved an area under the receiver operating characteristic curve (AUC) of 0.81, 0.91, and 0.71 for predicting mutations in KIT, PDGFRA and wild type, respectively, in cross-validation and 0.76, 0.90, and 0.55 in independent testing. Notably, PDGFRA exon18 D842V mutation, which is resistant to Imatinib, was predicted with an AUC of 0.87 and 0.90 in cross-validation and independent testing, respectively. Additionally, novel histological criteria predictive of patients’ outcome and mutations were identified by reviewing the tiles selected by the models. As a proof of concept, our study showed the possibility of implementing DL with digitized WSI and may represent a reproducible way to improve tailoring therapy and precision medicine for patients with GIST.
Molecular Imaging of Glial Tumors: Established and Emerging Tracers
Authors: Dev Indraja D. , Rangarajan Venkatesh , Purandare Nilendu C. , Puranik Ameya D. 
Published: July 2023

AbstractVarious positron emission tomography (PET) tracers have been developed and extensively studied in the field of neuro-oncology imaging. In the management of brain tumors, accurate delineation of tumor extent, assessment of treatment response, and detection of early recurrence are the most important factors. At present, conventional anatomical imaging paired with amino acid tracer PET imaging is the recommended imaging modality for glial tumor evaluation. Newer PET tracers targeting various structures in the tumor microenvironment have been extensively studied. This review summarizes the established and emerging PET tracers having potential impact on neuro-oncology practice.
Frequency and Reasons for Vaccination Failure against Measles among Pediatric Cases at a Tertiary Care Hospital of Karachi
Authors: Jamal Ammarah , Nasir Sharmeen , Hayee Faiza , Yahya Yousuf 
Published: July 2023

Abstract
Objective A nationwide measles–rubella (MR) vaccination campaign was executed in Pakistan in November 2021. Despite that, there was a persistence of new measles cases. Thus, we designed this study to determine the measles vaccination status in patients with measles and to determine the reasons of missed vaccination during the campaign.
Methods We reviewed medical records of measles patients >1 month to 12 years of age, presenting to the pediatric emergency of a tertiary care hospital of Karachi, Pakistan, during January to June 2022. We recorded patients' demographics and vaccination status. Measles patients who were hospitalized were reviewed to see if the child has or has not received vaccination during the MR campaign and what were the reasons for missed vaccination.
Results A total of 1,058 children presented with measles out of which 52.9% were male. The mean age of the patients was 2.2 years. Excluding 24.3% of the patients because of age <9 months, 800 (75.6%) patients were eligible for measles vaccine. Out of these, 80% received the vaccine (94.6% had one dose and only 5.3% had two doses). Among the 98 admitted patients, 68 (69.3%) were eligible for vaccination during the MR campaign, out of which 88.2% did not get the vaccine. Common reasons of missed vaccination were: lack of knowledge of the campaign (36.6%), impossibility to find vaccination facility (23.3%), and lack of trust in vaccines (15%).
Conclusion Most of the hospitalized measles patients had missed the vaccine during the MR campaign, mostly because of lack of knowledge of the campaign. This calls for devising strategies to improve coverage of vaccination services.
Determination of Isometric Points in the Stifle of a Dog Using a 3D Model
Authors: Yair Nadav , Yiapanis Christos , Ben-Amotz Ron , Meiner Yaron , Shapiro Amir , Milgram Joshua 
Published: July 2023

AbstractObjective The aim of this study was to develop a three-dimensional (3D) model to identify the isometric component of the cranial cruciate ligament (CCL) in dogs.Methods A static 3D model of the specimen was generated from a computed tomography scan of the stifle of a dog and a kinematic model was generated from data collected, every 5 degrees from full extension (131 degrees) through 80 degrees of stifle flexion, from four sensors attached to the tibia. Kinematic data were superimposed on the static model by aligning the points of interest, which were defined for both models. This allowed the tibia to rotate and translate relative to the femur based on the kinematic data. The contours of the distal femur and proximal tibia were converted into point clouds and the distance between each point in the femoral point cloud and all the points in the tibial point cloud were measured at each of the 15 positions. The difference between the maximum and minimum distances for each pair of points was calculated, and when it was less than 0.2 mm, points were illustrated as two red dots connected by a line at their locations on the femur and tibia.Results A total of 3,681 pairs of isometric points were identified and were located at the origin and insertion of the CCL and on the lateral aspect of the stifle.Conclusion Isometric areas are present at the origin and insertion of the CCL and lateral aspect of the stifle. Better understanding of these locations may lead to refinements in techniques to replace the ruptured CCL.
Dance, Institution, Abolition
Authors: Chaganti Seeta 
Published: July 2023

AbstractAntiracist commitments—in medieval studies and elsewhere—are incomplete without a commitment to abolitionist principles. These principles involve the dismantling of police, prisons, and many other institutions fostering the interests of carcerality, property protection, and racial capitalism. This essay encourages scholars of medieval dance to explore abolitionist horizons because, it argues, the study of medieval dance requires the development of three capacities also integral to the abolitionist project: 1) an ability to envision what we cannot know; 2) an understanding of how to act collectively even through our estrangement from each other (as medieval dancers did); 3) a willingness to take risks. These characteristics could help scholars of dance confront medieval studies and mobilize it to make not just the field but also the world a place of freedom, thriving, and mutual care.
EFL teachers’ awareness of dyslexia
Authors: Nushi Musa , Eshraghi Mitra 
Published: July 2023

Abstract
Dyslexia is one of the most common learning disabilities among
students, and teachers are often the very first to notice dyslexic students. It
is therefore imperative that teachers be well-prepared to intervene
appropriately and effectively once they encounter dyslexic students. The current
study investigates teachers’ knowledge about the disorder in an English as a
foreign language (EFL) context. Employing a questionnaire designed by Soriano et al. (2016), the study
evaluates the awareness of dyslexia among 84 Iranian English teachers working in
language institutes. The findings revealed that the majority of the teachers
lacked adequate knowledge of the disorder but that they wished to learn more
about this learning disability. Furthermore, the teachers’ awareness of the
disorder was found to be independent of their demographic characteristics such
as gender, previously completed programs, years of teaching experience, and
experience with dyslexic students. The findings of this research can be
informative for teacher educators, curriculum designers, and materials
developers as there seems to be a need for revisions in teacher training
curricula, instructional policies, and materials.
Migration linguistics
Authors: Borlongan Ariane Macalinga 
Published: July 2023

AbstractMigration, among the most important sociocultural phenomena of contemporary global societies, is complex, dynamic, and multifaceted. At the heart of migration is language, the indispensable agent of migration. Hence, in this article, a new sub-discipline of linguistics is presented, and that is ‘migration linguistics’. It is the interdisciplinary and multidimensional study of the various aspects of language within the dynamic process of human mobility. And a linguistic theory of migration postulates that: (1) Language is an essential element in the migration process; (2) an individual’s acquisition, learning, and use of language significantly changes as a result of migration; and (3) migrants must be understood in the languages they can use, taught the destination language, and provided basic and essential services understandable to them. The interdisciplinary nature of this new sub-discipline of linguistics is enriched by a variety of approaches and methodologies in solving issues relative to language in the context of migration.
Developing L2 listening comprehension through extensive and intensive
listening
Authors: Karlin Omar , Karlin Sayaka 
Published: July 2023

Abstract
In the fall semester of 2020, 269 Japanese university students
were compared in a quasi-experimental study to determine whether extensive and
intensive listening interventions yielded significant gains in L2 listening
comprehension. At the beginning of the study, 269 students took a 100-item L2
listening exam, and were randomly placed into an extensive
(n = 135) or intensive listening group
(n = 134). After each group completed five assignments based on
extensive or intensive listening principles, students took another 100-item L2
listening exam. Paired-sample t-tests of raw scores and Rasch person ability
estimates indicated that the extensive listening group significantly improved in
raw scores, t(134) = −7.44, p = .00, but not
in Rasch person ability estimates t(134) = −1.86,
p = .07, while the intensive listening group significantly
improved in both raw scores, t(133) = −9.48,
p = .00, and Rasch person ability estimates,
t(133) = −3.58, p = .00.
Addressing race in English language teaching
Authors: Coachman Erika de Freitas , Fernandes Izabelle da Silva 
Published: July 2023

AbstractThe aim of this paper is to analyze a set of didactic materials developed to teach English as an Additional Language at a Brazilian public school in Rio de Janeiro. Such materials were designed to invite 7th grade students with diverse social, racial, and economic backgrounds to learn about the world and the English language from viewpoints that delineate a decolonial stance (Mignolo, 2010;Kumaravadivelu, 2016;Jansen, 2017). Grounded on the notions of Critical Race Literacy (Ferreira, 2014) and Critical Language Awareness (Alim, 2005), this paper looks into didactic activities built upon emancipatory (Freire, 1996) and transgressive (Pennycook, 2006;hooks, 2013) approaches to Applied Linguistics and Language Education, understanding English Language classrooms as privileged arenas for the construction of ideas on race. The methodological approach is based on the premises of a Dialogical Discourse Analysis (Brait, 2006/2018) to identify centripetal and centrifugal forces (Bakhtin, 1981) in the didactic materials produced. Results have indicated that the discourse genres selected (Bakhtin, 2003/1979apudTilio, 2017) and the set of activities developed are permeated by social voices (Bakhtin, 1981) that promote decolonial dialogues in the English language classroom.
The development of EFL students’ speech fluency
Authors: Marzuki Dony 
Published: July 2023

Abstract
This study investigated phase transitions in EFL students’ speech fluency development using a complex dynamic
systems perspective. Two students with different proficiency levels were selected from an intact speaking class. These students
learned and practiced specific strategies to improve their speech fluency. Phase transitions were analyzed based on three criteria:
sudden jumps, anomalous variance, and qualitative change in the attractor. Number of syllables was used as the speech fluency
measure. The results suggest that only the higher-proficiency student underwent one phase transition. These findings imply that a
short explicit fluency strategy training intervention could improve the speech fluency development of high-proficiency students in
EFL classrooms. The results have implications for theory and pedagogical practice relating to EFL students’ speech fluency
development.
Fortifying cuteness
Authors: Crosby Drew , Dalola Amanda 
Published: July 2023

Abstract
The term aegyo refers to a cute style of speech
in Korean with numerous reported phonetic correlates. One of these is obstruent
fortition (OF). The present study examines the gender and age effects of OF
across 21 romantic couples and across eight mock situations (date, workplace,
family, comfort, date-planning, request, expression of love). Results revealed a
significant interaction between performance of aegyo and
age, such that younger participants exhibited higher rates of
OF when performing aegyo than when not performing
aegyo, whereas older participants did not. Results also
revealed a gender effect such that women employed more OF than
men, and a situation effect such that OF was more likely to occur in
romantic situations, suggesting its indexicality of romantic intimacy.
Walter Benjamin as translator as John Henry
Authors: Robinson Douglas 
Published: July 2023

AbstractThe article invokes John Henry’s fatal competition with the rock-driving machine, a legendary exemplar of resistance to automation, as a speculative analogue of Walter Benjamin’s 1923 essay “Die Aufgabe des Übersetzers,” read as a metaphysical attempt to develop a workable alternative to the kind of mechanizable translating he hated. Benjamin’s practical work with Baudelaire and Proust and the others is read tentatively as the forerunners to machine translation eighty-plus years later – working with the meanings of individual words in sentential chunks, striving to organize them along the lines of statistical usage in the target language, and incrementally learning with each translation job to assimilate actual reproductions of sentential meaning more and more accurately to statistical usage. “Die Aufgabe des Übersetzers” by contrast, read as his anti-MT manifesto, opens up to a somatic phenomenology of felt (super)human life.
Ethical issues for literary translation in the Era of artificial intelligence
Authors: Bo Li 
Published: July 2023

Abstract
Technological advancement has brought changes to many professions across the world. Furthermore, it has triggered
a discussion about ethical issues. Machine Translation (MT) or Computer-Aided Translation (CAT)
has vastly increased work efficiency and technology-related ethical issues are gaining academic attention these days. However, the
discussion of ethical issues for literary translation against the backdrop of Artificial Intelligence (AI) is limited. After a
quick review of the stages of MT, this paper will delve into literary translation’s emerging ethical issues, for example, the
literary translator’s professional identity and copyright. Copyright ethics is an indispensable part of AI-enabled literary
translation since training data and participatory NMT involve copyright issues. This study revealed that technological advancement
will facilitate literary translation. However, no direct evidence exists that machine translation will replace human translators.
Given the new working mode of “multi-players” or participatory translation, ethical issues arising from the human and machine
interaction merit further academic inquiry.
The many guises of machine translation
Authors: Nunes Vieira Lucas 
Published: July 2023

AbstractMachine translation (MT) tools are widely available. They may be present in different spaces in ways that consumers of the content do not necessarily control or realise, and research to date has paid little attention to these human-MT encounters. This article draws on the philosophy of technology literature to consider implications of MT’s permeating presence in online environments as well as in face-to-face interactions. The focus of the article is on two situations where humans can come across MT: while browsing websites and when speaking with figures of authority. The article highlights ways in which humans’ relationship with MT transcends conscious decisions to operate an MT tool directly. It argues that the human-MT relationship can also be one of immersion where MT blends with the environment in ways that, on the one hand, break language barriers but, on the other, influence, persuade, and on occasion misinform.
An analysis of the Spanish dubbing of the video game Iron Man
2
Authors: Rodríguez Fernández-Peña Alfonso Carlos 
Published: July 2023

Abstract
Our study was motivated to investigate reasons why the Spanish
localisation of the video game Iron Man 2 (Sega 2010) attracted extensive
criticism. Scholars and gamers alike labelled it “abysmal” (Mejías-Climent 2021b, 134) and among
the worst dubbing in Spanish of all time in the video game history. This article
provides a descriptive and empirical analysis of the Spanish dubbing of the
cinematic scenes of the game. We have focused our analysis, firstly, on the
synchrony of the 50 cinematic scenes following Mejías-Climent’s (2021b) levels of restriction and
types of dubbing synchronies, and, secondly, on the voice actors’ performance
(acting, pronunciation and diction) and voice quality (character coherence) for
the most relevant game characters by applying the methodology for voice quality
analysis, drawing on Bosseaux (2015,
2018) and Rodríguez Fernández-Peña (2020). The results show that
there has been a chain of oversights in the dubbing process, involving dubbing
directors, voice actors and testers, which likely contributed to the negative
reviews of the localised version in Spanish.
Multi-skyrmion states in the Skyrme model with a false vacuum potential*
Authors: Wang Jun-Shuai , Ma Yong-Liang 
Published: July 2023

Abstract
We study multi-skyrmion states using the Skyrme model with a false vacuum potential up to baryon number

using the product ansatz. It is found that both the false and true vacuum potentials can result in a cluster structure for the multi-skyrmion states. We also analyze the effect of explicit chiral breaking on the masses and contour surfaces of the baryon number density of the multi-skyrmion states.
Deligne–Lusztig duality on the moduli stack of bundles
Authors: Chen Lin 
Published: July 2023

Let

Bun

G

⁡
(
X
)

\operatorname {Bun}_{G}(X)

be the moduli stack of

G
G

-torsors on a smooth projective curve

X
X

for a reductive group

G
G

. We prove a conjecture made by Drinfeld-Wang and Gaitsgory on the Deligne–Lusztig duality for D-modules on

Bun

G

⁡
(
X
)

\operatorname {Bun}_{G}(X)

. This conjecture relates the pseudo-identity functors given by Gaitsgory [Ann. Sci. Éc. Norm. Supér. (4) (2017)] and Drinfeld and Gaitsgory [Camb. J. Math. 3 (2015), pp. 19–125] to the enhanced Eisenstein series and geometric constant term functors given by Gaitsgory [Astérisque (2015)]. We also prove a “second adjointness” result for these enhanced functors.