bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internet addiction and associated factors among undergraduate students of Jimma university; Jimma South West Ethiopia. Institutional Based cross-sectional Study
Authors: Amano Abdulkerim , Ahmed Gutema , Nigussie Kabtamu , Asfaw Henock , Fekadu Gelana , Hiko Ahmed , Abdeta Tilahun , Soboka Matiwos 
Published: April 2023

Abstract

Background Internet addiction is a condition that affects cognitive function, which has a detrimental impact on students' academic performance and increases their risk of experiencing psychological crises including anxiety and sadness.Objectives Examining the prevalence of internet addiction and its contributing factors among regular undergraduate students at Jimma University in South West Ethiopia was the primary goal of this study.Methods An institutional-based cross-sectional study design using a multistage random sampling technique among 772 students was conducted. We collected the data using pretested and structured questionnaires with self-administered techniques. We measured internet addiction with the Young Internet Addiction Test (YIAT). Epi Data Manager version 4.6 was used to enter data, which was then exported to SPSS version 25 for analysis. Descriptive statistics, bivariable and multivariable logistic regression models were used to analyze possible confounders, and variables at p-value less than 0.05 were declared as independent predictors of internet addiction.Result The prevalence of internet addiction among Jimma University, regular undergraduate students was 53.6%, (95% Confidence Interval (CI); (49.99%, 57.15%). Being dissatisfied with major study (AOR: 4.827, 95% CI = 2.029–11.484) and having a cumulative grade point average of promoted grade report (AOR|): 2.119, 95% CI = 1.321–3.397 Using the internet for entertainment (AOR: 1.558, 95% CI = 1.113–2.180), using the internet for Face Book (AOR: 2.780, 95% CI = 1.471–5.253), using the internet for telegram (AOR: 2.197, 95% CI = 1.434–3.365), depression (AOR: 2.061, 95% CI = 1.463–2.903), social anxiety (AOR: 4.565, 95% CI = 1.254–16.610) and poor social support (AOR: 2.132, 95% CI = 1.358–3.346) had significant associations with internet addiction.Conclusion This study revealed a comparatively high frequency of internet addiction among Jimma University students. Internet dependance was found to be associated with promoted grade reports, poor satisfaction with major studies, using the internet for entertainment, Facebook and Telegram, depression, social anxiety, and poor social support. As a result, integrating the efforts of stakeholders, including the ministry of education and universities, on the identified factors and raising awareness among university students would be a beneficial step toward reducing this high prevalence.
An economic assessment of the effect of agricultural extension activities on increasing production and farmers’ revenue: The case of irrigated wheat Production-Extension Model Sites in Iran
Authors: Amghani Mohammad Shokati , Mojtahedi Mehrdad , Savari Moslem 
Published: April 2023

Abstract
Agricultural extension is a key instrument to accomplish sustainable agricultural development by improving knowledge penetration in the agricultural sector. (EMSs) are a new extension approach in agriculture to create proper models for empowering farmers. This research analyzes the effect of EMSs on increasing irrigated wheat production versus the previous cultivation period. The statistical population was composed of the main farmers of irrigated wheat EMSs (N = 355) throughout Iran. The sample size was determined to be 180 by Cochran’s formula. The sample was taken by the stratified random sampling technique with proportional allocation. The results of the estimation of production cost function and extension activities cost showed that the variable of extension activities significantly affected irrigated wheat yield with a coefficient of 0.32 at the P < 0.01 level. The extension investment return in the EMSs was 0.66 t/ha. Based on the results, out of the final production value of the extension services provided to the main farmers, 13.3 percent had been spent as the cost of extension activities and 86.7 percent had been net profit gained by farmers. The results of the correlated t-test for farmers’ behavior before and after receiving the extension services showed significant differences in the amount of seed consumption, tillage cost per ha, labor cost per ha, irrigation frequency, the rate of biofertilizer and urea application, crop waste during harvest, the production cost of irrigated wheat per kg, crop yield, and income and net production profit per ha.
Forecasting ocean wave-induced seismic noise
Authors: Bertoldi Andrea , Gaffet Stéphane , Prevedelli Marco , Smith David A. 
Published: April 2023

Abstract

Ocean waves induce the power peak in the seismic ground motion seen everywhere in the world
between 0.03 Hz and 1 Hz, defining the seismic noise baseline. The precise generation mechanisms
are well understood, and the dependence of seismic noise on sea weather has been precisely quantified
using long-term time series. However, this knowledge has never been exploited to forecast the seismic
noise background. Here we report the prediction of the mid-frequency seismic noise spectrum at
the Low-Noise Underground Laboratory (LSBB) in Rustrel, for up to 16 days in advance, limited
by the time span of sea weather forecasts. We first characterize the dependence of the seismic noise
at the LSBB on the Mediterranean Sea and Atlantic Ocean weather, using buoy data for 2020-21.
We exploit significant correlation in the 0.15 Hz < f < 2.5 Hz frequency band to make predictions,
converting sea weather forecasts into seismic noise forecasts. The expected seismic background noise
can be used to optimize the performance and running costs of scientific and industrial activities,
by scheduling them during quiet intervals or adopting adaptive data analysis techniques to identify
target signals in the predicted noise.
Post-infection functional gastrointestinal disorders following coronavirus disease-19: A Prospective follow-up cohort study
Authors: Zhang Daya , Chen Chen , Xie Yunqian , Zeng Fan , Chen Shiju , Chen Runxiang , Zhang Xiaodong , Huang Shimei , Li Da , Bai Feihu 
Published: April 2023

Abstract
Background:Acute gastrointestinal infections can lead to post-infectious irritable bowel syndrome (PI-IBS). Moreover, coronavirus disease (COVID-19) is related to long-term gastrointestinal sequelae. In this study, the frequency, disease spectrum, and risk factors for post-infection functional gastrointestinal disease (PI-FGID) in COVID-19 patients and healthy controls were prospectively examined.
Methods: Validated Rome III and Rome IV questionnaires were used to assess the incidence of PI-FGID in 190 COVID-19 patients, and 160 healthy controls prospectively followed for 1, 3, and 6 months.
Results:Six（3.2%）, 1（0.5%）, 3（1.6%）, 5（2.6%）, 6（3.2%）COVID-19 patients had diarrhea, abdominal pain, constipation, dyspepsia and their overlap at 1 month, respectively, while 4（2.1%）, 1（0.5%）, 4（2.1%）, 4（2.1%）, and 6（3.2%）COVID-19 patients had diarrhea, abdominal pain, constipation, dyspepsia and their overlap at three months, respectively. Furthermore, 2（1.3%）, 4（2.5%）, and 3（1.9%）healthy controls developed constipation, dyspepsia, and their overlap at one month, respectively (P=0.193), while 2（1.3%）, 4（2.5%), and 2（1.3%）healthy controls developed constipation, dyspepsia and their overlap at three months, respectively (P=0.286). FGIDs incidence was higher among COVID-19 patients（8.9%) than in healthy controls（3.1%) at 6-month follow-up (P=0.025). Moreover, 7 (3.7%), 5 (2.6%), 3 (1.6%), and 2 (1.1%) COVID-19 patients developed IBS, functional dyspepsia（FD）, functional diarrhea（FDr）, functional constipation（FC）at six months, respectively, while only 2 (1.3%) and 3 (1.9%) healthy controls developed IBS and FD at six months, respectively. Notably, gastrointestinal（GI）symptoms at onset were the independent risk factors for post-COVID-19 FGIDs at six months.
Conclusions: COVID-19 increases new-onset PI-FGID at six months compared with healthy controls. GI symptom at the onset of COVID-19 is an independent risk factor for post-COVID-19 FGIDs.
Sclerostin antibody improves alveolar bone quality in the Hyp mouse model of X-Linked Hypophosphatemia (XLH)
Authors: Ross Ryan , Carpenter Kelsey , Alkhatib Delia , Dulion Bryan , Guirado Elizabeth , Patel Shreya , Chen Yinghua , George Anne 
Published: April 2023

Abstract
X-linked hypophosphatemia (XLH) is a rare disease of elevated fibroblast growth factor 23 (FGF23) production that leads to hypophosphatemia and poor mineralization of bone and teeth. The clinical manifestations of XLH include a high prevalence of dental abscesses, likely driven by poorly formed structures of the dentoalveolar complex, including the alveolar bone, cementum, dentin, and periodontal ligament. Our previous studies have demonstrated that sclerostin antibody (Scl-Ab) treatment improves phosphate homeostasis, and increases bone mass, strength and mineralization in the Hyp mouse model of XLH. In the current study, we investigated whether Scl-Ab impacts the dentoalveolar structures of Hyp mice. Male and female wild-type and Hyp littermates were injected with 25 mg/kg of vehicle or Scl-Ab twice weekly beginning at 12 weeks of age and euthanized at 20 weeks of age. Scl-Ab increased alveolar bone mass in both male and female mice and alveolar tissue mineral density in the male mice. The positive effects of Scl-Ab were consistent with an increase in the fraction of active (non-phosphorylated) β-catenin stained alveolar osteocytes. Scl-Ab had no effect on mineralized tissues of the tooth - dentin, enamel, acellular and cellular cementum. There was a non-significant trend toward increased periodontal ligament (PDL) attachment fraction within the Hyp mice. Additional PDL fibral structural parameters were not affected by Scl-Ab. The current study demonstrates that Scl-Ab can improve alveolar bone in the Hyp mouse model of XLH.
Isolation and propagation of an Egyptian Theileria annulata infected cell line and evaluation of its use as a vaccine to protect cattle against field challenge
Authors: AL-Hosary Amira , Radwan Ahmed M. , Ahmed Laila S. , Abdelghaffar Sary Kh. , Fischer Susanne , Nijhof Ard M. , Clausen Peter-Henning , Ahmed Jabbar S. 
Published: April 2023

Abstract
Tropical theileriosis is an important protozoan tick-borne disease of cattle. Vaccination using attenuated schizont cell lines is one of the methods used for controlling the disease. This study describes the production of an attenuated T. annulata cell line from Egypt and an evaluation of its use as a vaccine to protect calves against clinical disease upon field challenge. Two groups of exotic and crossbred male calves were divided into vaccinated and control groups. Vaccinated groups were inoculated with 4 ml (1 x 106 cells/ml) of the attenuated cell line. Three weeks after vaccination, calves of both groups were transported to the New Valley governorate where they were kept under field conditions and exposed to natural T. annulata challenge. All animals of the control group showed severe clinical signs and died despite treatment with buparvaquone after a severe drop in the packed cell volume (PCV). Animals of the vaccinated group became seropositive without developing serious clinical signs except for the transient fever. Post-mortem examinations revealed enlarged and fragile lymph nodes, spleen, and liver with necrosis and hemorrhages. These findings indicate that the Egyptian attenuated cell line was successful in protecting both exotic and crossbred animals against tropical theileriosis under field conditions.
A nomogram for predicting lateral lymph node metastasis in cN0 unifocal papillary thyroid microcarcinoma
Authors: Huang Hui , Xu Siyuang , Ni Song , Wang Xiaolei , Liu Shaoyan 
Published: April 2023

Abstract
Background Identifying risk factors for occult lateral LNM in PTMC can assist in determining the necessity of LND and other measures to reduce the risk of recurrence. This study aimed to establish a nomogram for predicting the probability of lateral lymph node metastasis (LLNM) in patients with cN0 unifocal papillary thyroid microcarcinoma (PTMC).Methods We retrospectively analyzed a total of 4872 patients with cN0 unifocal PTMC who were treated at our center from January 2013 to June 2018. Logistic regression tests were used to determine the risk factors for LLNM. A nomogram was constructed based on these risk factors.Results The rate of LLNM was 3.2%. Tumors located in the upper lobe (OR = 2.56, 95% CI 1.80–3.62; p < 0.001) and size greater than 7 mm (OR = 2.59, 95% CI 1.85–3.62; p < 0.001) had a 2.5-fold higher risk of LLNM than tumors in the lower or middle lobe and size less than or equal to 7 mm. Tumors with extrathyroidal extension (ETE) had a significantly higher risk of LLNM (OR = 1.41, 95% CI 1.01–1.99; p = 0.044). Having three or more central lymph node metastases (CLNMs) (OR = 5.84, 95% CI 3.83–8.93; p < 0.001) or having one or two CLNMs (OR = 2.91, 95% CI 1.93–4.42; p < 0.001) both had a higher risk of LLNM than having no CLNMs. A nomogram was developed based on these risk factors. The ROC curve for predicting LLNM showed that the AUC was 0.777, indicating a high degree of consistency.Conclusion Tumors located in the upper lobe, greater than 7 mm in size, ETE, and CLNMs, especially three or more, were independent risk factors for LLNM in cN0 unifocal PTMC. The nomogram based on these factors had favorable predictive value and consistency, but further prospective research is needed to validate these findings.
High-quality chromosome-level genome assembly of the plant bug Pachypeltis micranthus provides insights into the availability of Mikania micrantha control
Authors: Wang Xiafei , Zhao Ning , Cai Liqiong , Liu Naiyong , Zhu Jiaying , Yang Bin 
Published: April 2023

AbstractBackgroundThe plant bug,Pachypeltis micranthusMu et Liu (Hemiptera: Miridae), is an effective potential biological control agent forMikania micranthaH.B.K. (Asteraceae; one of the most notorious invasive weeds worldwide). However, limited knowledge about this species hindered its practical application and research. Accordingly, we sequenced the genome of this mirid bug, which is of great significance forM. micranthacontrol.ResultsHere, we generated a 712.72 Mb high-quality chromosome-level assembly ofP. micranthus, of which 707.51 Mb (99.27%) of assembled sequences were anchored onto 15 chromosomes with contig N50 of 16.84 Mb. TheP. micranthusgenome had the highest GC content (42.43%) and the second highest proportion of repetitive sequences (375.82 Mb, 52.73%) than the three other mirid bugs (i.e.,Apolygus lucorum,Cyrtorhinus lividipennis, andNesidiocoris tenuis). Phylogenetic analysis showed thatP. micranthusclustered with other mirid bugs and diverged from the common ancestor approximately 200.01 million years ago. We analyzed gene family expansion and or contraction and manually identified some significantly expanded gene families associated withP. micranthusfeeding and adaptation toM. micrantha. Compared with the whole body, transcriptome analysis of the salivary gland revealed that most of the upregulated genes were significantly associated with metabolism pathways and peptidase activity, particularly among cysteine peptidase, serine peptidase, and polygalacturonase; this could be one of the reasons for precisely and highly efficient feeding by the oligophagous bugP. micranthusonM. micrantha.ConclusionCollectively, this work provides a crucial chromosome-level genome resource to study the evolutionary adaptation between mirid bug and their host. It is also helpful in searching for novel environment-friendly biological strategies to controlM. micrantha.
Identifying barriers and facilitators to the inclusion of older adults living in UK care homes in research: a scoping review
Authors: Nocivelli Brittany , Shepherd Victoria , Hood Kerenza , Wallace Carolyn , Wood Fiona 
Published: April 2023

Abstract
Background
With an ageing population, older adults will have more complex health and social care needs and many of these older adults will be living in care homes. Despite the growth in care home populations, care home residents are often excluded from research that could potentially benefit their care. The purpose of this scoping review is to explore resident-related barriers and facilitators to including older people living in UK care homes in research and to identify potential approaches to modify such barriers.
Method
The 6-stage scoping review methodology framework proposed by Arksey and O’Malley guided this review. Five electronic databases (MedLine, PsychINFO, Scopus, Web of Science, CINAHL) and grey literature were searched. Identified articles went through two levels of screening, and those deemed relevant were collated, summarised and reported using a thematic analysis approach.
Results
90 reports were eligible for inclusion and, were synthesised into 7 themes and related subthemes: (1) research design; (2) understanding and beliefs about research (resident and care home staff); (3) communication; (4) relationships; (5) eligibility criteria (resident and care home); (6) preference-based decisions; and (7) care home staff and environment. Given the complex interplay of the factors identified, both direct and indirect factors were included.
Conclusions
A number of recurring barriers and facilitators to the inclusion of care home residents in research are reported. However, isolating resident-related barriers was complex as both direct and indirect factors must be considered as influential. Understanding the barriers to inclusion will enable these factors to be addressed as increase the evidence-base for care provided to older people living in care homes.
Development and evaluation of patient-specific kidney surgical guide fabricated using 3D printing technology and realistic kidney phantom for partial nephrectomy
Authors: Ock Junhyeok , Kim Taehun , On Sungchul , Lee Sangwook , Kyung Yoon Soo , Kim Namkug 
Published: April 2023

Abstract
Partial nephrectomy has been demonstrated to preserve renal function compared with radical nephrectomy. Computed tomography (CT) is used to reveal localized renal cell carcinoma (RCC). However, marking RCC directly and quantitatively on a patient's kidney during an operation is difficult. We fabricated and evaluated a 3D-printed kidney surgical guide (3DP-KSG) with a realistic kidney phantom. The kidney phantoms including parenchyma and three different RCC locations and 3DP-KSG were designed and fabricated based on a patient's CT image. 3DP-KSG was used to insert 16-gauge intravenous catheters into the kidney phantoms, which was scanned by CT. The catheter insertion points and angle were evaluated. The measurement errors of insertion points were 1.597 ± 0.741 mm, and cosine similarity of trajectories was 0.990 ± 0.010. The measurement errors for X-axis, Y-axis, and Z-axis in the insertion point were 0.611 ± 0.855 mm, 0.028 ± 1.001 mm, and − 0.510 ± 0.923 mm. The 3DP-KSG targeted the RCC accurately, quantitatively, and immediately on the surface of the kidney, and no significant difference was shown between the operators. Partial nephrectomy will accurately remove the RCC using 3DP-KSG in the operating room.
Mercury (II) sensor by forming Hg/Ag amalgam based on silver nanoparticles modified screen-printed carbon electrode
Authors: Wang Qihui , Zhan Yifang , Peng Junjun , Liu Huihong 
Published: April 2023

Abstract
The fabrication of a silver nanoparticles/chitosan/carbon nanotubes modified screen-printed carbon electrode (SPCE) as a highly sensitive platform for ultratrace mercury (II) detection was reported here. Silver nanoparticles (AgNPs) were synthesized by chitosan (CS) and carbon nanotube (CNT) hybrids with a green way. Chitosan trapped AgNPs anchoring on the sidewalls of the CNT arrange the nanoscale silver electrode arrays. Hg/Ag amalgam was formed on the surface of AgNPs/CS/CNT modified SPCE by depositing the mercury species to elemental mercury. Hg(II) detection is achieved by the stripping both Hg0 and Ag0 at +0.16V in the supporting electrolyte (0.1M HCl and 0.1 M KCl). This selective and sensitive detection method exhibits an excellent linear Hg(II) concentration range of 1.0 nM to 12.6 nM and a low detection limit of 0.4nM with R2 = 0.982 (n=13). The newly designed electrode has been successfully employed to measure Hg(II) in the textile samples with a good stability. The method demonstrates acceptable reproducibility and precision.
Aortic endograft infection by Mycobacterium abscessus subsp. massiliense with acquired clarithromycin resistance is associated with unreported gene mutations: A case report
Authors: Akiyama Yutaro , Iwamoto Noriko , Kamada Keisuke , Yoshida Atsushi , Osugi Asami , Mitarai Satoshi , Suzuki Tetsuya , Yamamoto Kei , Nagashima Maki , Horai Tetsuya , Ohmagari Norio 
Published: April 2023

Abstract
Background
Mycobacterium abscessus subsp. massiliense (MMA) comprises a group of non-tuberculous, rapidly growing mycobacteria. Although MMA can cause pulmonary diseases, surgical site infections, and disseminated diseases, aortic endograft infection has not been reported. Here, we describe the first case of aortic endograft infection caused by MMA.
Case presentation
Two months after stent-graft insertion for an abdominal aortic aneurysm, an 85-year-old man was admitted with fever and abdominal pain and was diagnosed with aortic endograft infection. Despite 14 days of meropenem and vancomycin intravenous administration, periaortic fluid pooling increased as compared to that before antibiotic administration. The abscess was drained, and fluorescent acid-fast staining of the abscess fluid revealed bacilli. The organism was identified as MMA by genetic testing. Intravenous imipenem–cilastatin (IPM/CS), amikacin (AMK), and oral clarithromycin (CAM) were administered. After 2 months, oral CAM and sitafloxacin were administered because the abscess had decreased in size. However, after 6 weeks, the abscess increased in size again. Antimicrobial susceptibility testing of the drainage fluid from the abscess resulted in the isolation of an MMA strain that had acquired resistance to CAM. Intravenous IPM/CS, AMK, and oral linezolid were added to the treatment regimen along with oral CAM and STFX. However, he was not fully cured and died 6 months later. Neither the full-length erythromycin ribosome methyltransferase (erm)(41) gene nor the rrl or rpIV gene mutations were found by Sanger sequencing in the pre- and post-treatment strains. Whole-genome sequence analysis of the post-treatment strain revealed mutations in genes with no previous reports of association with macrolide resistance.
Conclusions
Aortic endograft infection caused by MMA strain is extremely rare; nonetheless, MMA should be suspected as the causative microorganism when broad-spectrum antimicrobials are ineffective.