bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors of intracerebral hemorrhage- a cross sectional study
Authors: Mir Jalal-ud-din  , Raheel Jehangir Jadoon  , Samia Wazir Khawaja  , Rashid Ali  , Syed Affan Ali  , Ibtisam  
Published: January 2023

BACKGROUND:
Stroke is the most common cause of disability and a leading cause of mortality worldwide. Though the incidence is falling in West but probably rising in Asia. The burden of stroke risk factors in Pakistan is enormous. Data on stroke incidence and prevalence from Pakistan is scarce; however, there are several reported case series in literature highlighting significant differences in terms of stroke epidemiology, risk factors and stroke subtypes/patterns. METHODS: This descriptive cross sectional study was conducted from August 2019 to February 2020, on 109 patients from medical units of DHQ Teaching Hospital Abbottabad. Diagnosis of cerebrovascular accidents was made on focal neurological deficit lasting more than 24 hours. CT scan brain was done in all patients to detect intra cerebral bleed. Detailed history and medical records were carefully scrutinized in the patients of intracerebral bleed to detect factors leading to it like uncontrolled hypertension. Fasting blood glucose, fasting serum cholesterol and fasting triglycerides were done to detect uncontrolled diabetes and hyperlipidemia. Data was collected on a structured proforma and analysed using SPSS 20. RESULTS: Majority of the patients were 39.81%(n=41) >70 years of age, 71 (68.93%) were male and 32 (31.07%) female, frequency of intracerebral bleed among patients presenting with acute cerebrovascular accidents was recorded in 8.74%(n=9), among them 66.67%(n=6) had history of uncontrolled hypertension, 44.44%(n=4) had diabetes and 33.33%(n=3) had hyperlipidemia.
CONCLUSIONS: Frequency of intracerebral bleed is higher among patients presenting with cerebrovascular accidents, hypertension is recorded the most common risk factor for this complication.
Post COVID-19 vaccine (SINOVAC) cerebral venous sinus thrombosis
Authors: Soban Khan  , Mariam Khalil  , Waqar Zaid 
Published: January 2023

Sinovac is an inactivated virus COVID 19 vaccine given emergency authorization for COVID 19 Pandemic. Different adverse reactions have been seen in after marketing of COVID 19 vaccines. Here we present a case of patient who developed cerebral venous sinus thrombosis two weeks after the first dose of SINOVAC vaccine.
Prevalence of depression in caregivers of stroke patients in Karachi, Pakistan
Authors: Mansoor Marium , Pirani Shahina , Aftab Rabeeka , Nadeem Tania 
Published: January 2023

OBJECTIVES
To determine the frequency of depression in caregivers of stroke patients at a tertiary care teaching hospital in Karachi Pakistan.
METHODS
A cross-sectional study was conducted among caregivers of stroke, who were recruited from the Aga Khan University Hospital Karachi Pakistan, between January 2018 to October 2018. Data was collected through the Urdu Hamilton rating scale for depression (HAM-D-U) and it was analyzed using descriptive and inferential statistics.
RESULTS
A total of 136 caregivers participated in the study. Among them, 44.1 % were male and 55.9% were female. The mean age of caregivers was 45.38 ± 10.33 years. Using the HAM-D-U scale, depression was present in 64 (47.1%) caregivers. Out of them (n=64), 46 (33.8%) caregivers had mild depression whereas 18 (13.2%) had moderate depression. Depression was found to have a significant relationship with the age of the patient (p=0.002), education level of caregiver (p= 0.012), employment status of caregiver (p=0.012), being a sole caregiver (p=0.039), and monthly family income (p=0.016).
CONCLUSIONS
Caring for patients with neurological disorders is highly challenging and demanding. The need for this role may arise unexpectedly in one’s life; leaving little space for adjustment and coping. Depression itself can be very paralyzing for the sufferer especially if moderate to severe in intensity. Depression in stroke caregivers can be missed as patients are the center of a clinical visit. Hence, strategies should be designed and reinforced to screen patients and caregivers for depression along with a pathway for an easy and timely referral.
THE EFFECT OF RELIGIOSITY ON LIFE SATISFACTION WITH ALTRUISM AS A MEDIATING VARIABLE
Authors: Taimoor Ahmed Shaikh  , M. Parnawa Putranta  , J. Ellyawati  
Published: January 2023

Background: A nurse who has strong religiosity has close relationship to God, doing the best at the job as the part of altruism behavior, and it will increase the life satisfaction.
Aim: This article therefore aims at analyzing the influence of religiosity on life satisfaction with altruism as mediation variable
Setting: Siloam Hospital and PKU Muhammadiyah Hospital Yogyakarta.
Methods: A cross-sectional design was employed and 187 respondents were selected Siloam Hospital and PKU Muhammadiyah Hospital Yogyakarta. Quantitative data were collected and analyzed by using descriptive and inferential statistics in which frequencies, percentages, mean, standard deviation and regression, also Sobel test were employed.
Results: The results show that religiosity has positive effect on altruism, religiosity has positive effect on life satisfaction, and this study also has result that altruism mediating the effect of religiosity on life satisfaction.
Conclusion: Altruism inherent in all religions is a determinant of life satisfaction. Individuals who have good religiosity will be encouraged to always do good on the basis of religion and it increases the individual's life satisfaction.
A COMPARATIVE ANALYSIS OF WOMEN’S RIGHTS IN ISLAMIC AND WESTERN LAWS IN TERMS OF HUDOOD AND TAAZIRAT
Authors: Rabia  , Abdul Rasheed  
Published: January 2023

War is recurrent factor of history that has not only affected the international orders and balance of power, but also impacted the society as general and women as particular. Women have been tortured during domestic and international conflicts. The women’s right violations and human casualties led nations to come up with some legal framework to mitigate and eliminate women suffering during conflicts and crises. The study focuses to draw a research review between Islamic Criminal Laws and Western International Criminal Laws focusing on women’s right. Islamic Criminal Laws has enunciated authentic principles regarding women rights; they cannot be killed during war and should be protected and respected as per their status if they are even Prisoner of War. Along with this, West has developed a lot of legal frameworks and Universal declarations regarding women’s rights in International Criminal Laws. Since the number of women who participated in war was insignificant until the outbreak of World War I, the need for special protection for them was not felt prior to that time. International Humanitarian Laws awarded them some general legal protection as men. If they wounded, women were protected by the provision of the 1864 Geneva Conventions. If women become prisoner of war, they benefited from the regulations of Hague Convention 1899 and 1907 on the Laws and Customs of War on Land. Similarly, under International treaties government are binded by legal obligation of Convention on the Elimination of all form of Discrimination against Women. This convention binds its member states to provide socio-economic and political rights to women and protect them against any discrimination and violence.
The Clinical Significance of pT3a Lesions as Well as Unilateral Versus Bilateral Invasion Into the Seminal Vesicle in Men With pT3b Prostate Cancer: A Proposal for a New pT3b Subclassification
Authors: Teramoto Yuki , Numbere Numbereye , Wang Ying , Miyamoto Hiroshi 
Published: January 2023

Context.—
Seminal vesicle invasion (SVI) as pT3b prostate cancer generally, but not uniformly, indicates poor prognosis.

Objective.—
To determine the clinical impact of pT3a lesions (ie, extraprostatic extension other than seminal vesicle or bladder invasion [EPE], microscopic bladder neck invasion [mBNI]), as well as unilateral (Uni) versus bilateral (Bil) SVI in pT3b disease.

Design.—
We assessed radical prostatectomy findings and long-term oncologic outcomes in 248 consecutive patients with pT3b disease.

Results.—
Focal EPE, nonfocal EPE, mBNI, Uni-SVI, and Bil-SVI were identified in 13 (5.2%), 206 (83.1%), 48 (19.4%), 109 (44.0%), and 139 (56.0%) cases, respectively. Of possible combinations, we eventually divided our cases into 3 cohorts—Group 1: Uni/Bil-SVI and EPE−/mBNI− (n = 28; 11.3%); Group 2: Uni-SVI and EPE or mBNI (n = 103; 41.5%); and Group 3: Bil-SVI and EPE or mBNI (n = 70; 28.2%) or Uni/Bil-SVI and EPE+/mBNI+ (n = 47; 19.0%). Group 3 patients showed significant adverse histopathologic findings, compared with Group 1 or Group 2 patients. Kaplan-Meier analysis revealed that the prognosis was worse in the following order: Group 1, Group 2, and Group 3; and the differences in progression-free survival between any 2 groups were statistically significant. These significant differences were also seen in subgroups, such as those without or with adjuvant therapy before recurrence and those without lymph node metastasis. Additionally, Group 3 patients had a significantly higher risk of cancer-specific mortality than Group 2 patients. In multivariate analysis (Group 2 as a reference), Group 1 (hazard ratio [HR] = 0.169, P = .01) and Group 3 (HR = 1.620, P = .04) showed significance for progression.

Conclusions.—
From these significant findings, we propose a novel pT3b subclassification, namely pT3b1 (Group 1), pT3b2 (Group 2), and pT3b3 (Group 3), which more accurately stratifies its prognosis.
A comparative study on third trimester fetal biometric parameters with maternal age
Authors: Poojari Yogitha , Annapureddy Prudhvinath reddy , Vijayan Sharmila , Kalidoss Vinoth Kumar , Mf Yuvaraj , Pk Sankaran 
Published: January 2023

Background
Advanced maternal age is an important parameter associated with increased risk of feto-maternal complications and it is an evolving trend in society for women planning for pregnancy in late ages. However there are no studies done whether advanced maternal age has its effects on expression of growth pattern in the fetus. So this study was done to compare the maternal age with the third trimester fetal biometric parameters.

Methods
This study was done in 100 antenatal women and divided into two groups: Group 1: optimal maternal age group between 21–29 years of age and Group 2: advanced maternal age 30 and above. The pre-pregnant maternal weight, gestational age and third trimester fetal biometrics using ultrasound are noted and compared between the groups.

Results
The maternal weight gain between the groups was optimal but the third trimester fetal parameters were significantly less in advanced maternal age. The abdominal circumference in optimal age group and head circumference in advanced maternal age group was closer to calculated estimated date of delivery (EDD) and would be specific in calculating the gestational age.

Conclusions
Though there is no significant difference in maternal weight gain, there are fetal growth restrictions in advanced maternal age group due to which the third trimester fetal parameters are lesser than the optimal age group. Head circumference would be specific in calculating the estimated date of delivery in advanced maternal age group.
Método de custeio do ciclo de vida adicionado (CCV Add) como alternativa de avaliação de ativos biológicos: uma análise comparativa com o Fair Value
Authors: Zielinski Fatima Luana , Stroparo Telma Regina 
Published: January 2023

Com objetivo apresentar a aplicação do Método de Custeio do Ciclo de Vida Adicionado (CCV Add) ou Life Cycle Costing (LCC) como alternativa na mensuração de um ativo biológico, comparando-o com o método de avaliação Fair Value, a presente pesquisa trata de alternativas de mensuração do Pinus taeda. Metodologicamente, a pesquisa caracteriza-se como descritiva, de abordagem quantitativa, bibliográfica, documental e estudo de caso com amostragem não-probabilística e por conveniência. A coleta de dados se deu em uma propriedade rural localizada no Município de Mallet/PR. Foram levantados dados relativos aos custos de implantação e manejo da cultura bem como os resultados advindos com a colheita e venda e aplicação das metodologias de avaliação de ativos biológicos. Os resultados apontam que existem diferenças significativas nas formas de avaliação dos custos e resultados. No entanto, não existem impactos financeiros no fluxo de caixa, independentemente de qual estratégia seja utilizada para avaliação dos ativos biológicos. Existem diferenças contábeis significativas na avaliação dos ativos e resultados patrimoniais e tal fato repercute nos demonstrativos financeiros.
Rise of Faculty Scholars: Building Capacity for a Stronger Future. Chiropractic Educators Research Forum (CERF), December 3, 2022
Authors:   Chiropractic Educators Research Forum
Published: January 2023

ABSTRACTThis conference was convened by the Chiropractic Educators Research Forum (CERF) on December 3, 2022. This meeting provided a forum for the presentation of scholarly works in education theory and practice. This conference specifically focused on research related to education research and building faculty scholarship and research capacity. During the December 2022 CERF meeting, presenters and panelists took an in-depth look at education research and how chiropractic programs work to enhance research and scholarship capacity.
Assessment of Consumer Attitudes Following Recent Changes in the US Hearing Health Care Market
Authors: Singh Jasleen , Dhar Sumitrajit 
Published: January 2023

ImportanceThe addition of over-the-counter hearing aid (HA) options has transformed the way individuals can access hearing health care (HHC). However, although critical to their adoption and use, consumer attitudes and opinions about direct-to-consumer (DTC) models of health care are often understudied.ObjectiveTo assess how recent DTC market changes in HHC delivery may be associated with consumer choice and attitudes towards specific HHC models.Design, Setting, and ParticipantsA mixed-methods survey, distributed online between March 22 and 25, 2022, using Qualtrics Survey Panels. Participants were US residents older than 50 years with no previous hearing aid experience, enrolled using consecutive sampling. A minimum of 1000 completed responses was set; once the 70% threshold was met, any future respondent who identified as White would not be given the survey.Main Outcomes and MeasuresRespondents were asked to report their level of comfort with using different variations of DTC-HHC and asked about their previous experience with other DTC health care models. Respondents then reported which model (in-person vs online) of HHC they would most likely pursue.ResultsOf 1377 respondents, 1037 were included in the survey study (mean [SD] age, 61.4 [7.84] years; 714 [69.0%] were female; 674 [65.0%] were White). Most respondents reported discomfort with pursuing hearing aids via DTC pathways, with 84% (874 of 1037) indicating they would pursue HHC via an in-person model. Individuals who were older (odds ratio [OR], 0.95; 95% CI, 0.92-0.98), reported an income greater than $150 000 (OR, 0.29; 95% CI, 0.08-0.91), and were not interested in HA (OR, 0.42; 95% CI, 0.23-0.79) were less likely to pursue HHC online. Those who had previous experience with DTC health care (OR, 1.97; 95% CI, 1.27-3.02), and did not have (OR, 2.61; 95% CI, 1.59-4.31) or were uncertain (OR, 2.05; 95% CI, 1.13-3.70) about their insurance coverage for HA were more likely to pursue HHC online.Conclusions and RelevanceCurrent consumer attitudes and opinions found in this survey study suggest that DTC-HHC may not find immediate acceptance by most potential HA seekers in the US.
Liquid‐Phase Epitaxy
Authors: Mauk Michael G. 
Published: January 2023

AbstractLiquid‐phase epitaxy (LPE) is a crystal growth method that produces single‐crystal films or layers of semiconductors and other types of materials on a supporting substrate. LPE‐grown structures include light‐emitting diodes (LEDs), laser diodes, and photodetectors; energy conversion devices such as photovoltaic cells, and various magnetic and optical devices. LPE is typically affected by solidifying a film comprising solute components precipitated from a molten metallic solution at temperatures ranging from several hundred to >1200 °C. A common LPE technology is based on a crucible slider apparatus in a temperature‐programmed furnace with a hydrogen ambient at atmospheric pressure. Multiple layer depositions generate a wide range of structures, and LPE has proven especially useful for III–V compound semiconductor heterostructures. Present‐day uses of LPE stem from favorable features such as fast growth rates, low defect densities, a wide choice of impurity dopants, and straightforward formulations based on phase equilibria and kinetics data and models. While LPE was a prominent epitaxy technology in the 1970s and 1980s, nowadays LPE is relegated to niche applications. Compared to competing epitaxy technologies such as molecular beam epitaxy (MBE) and metal–organic chemical vapor deposition (MOCVD), LPE falls short with regard to the achievement of ultrathin layered structures, strained or lattice‐mismatched structures, abrupt interfaces, and areal uniformity. Still, there are significant application areas well served by LPE or by modified LPE techniques, as reviewed here.
Reinforced Wool Keratin Fibers via Dithiol Chain Re‐bonding
Authors: Zhu Jin , Ma Ning , Li Shuo , Zhang Liang , Tong Xiaoling , Shao Yanyan , Shen Chao , Wen Yeye , Jian Muqiang , Shao Yuanlong , Zhang Jin 
Published: January 2023

AbstractRegenerated wool keratin fibers (RWKFs) have heretofore attracted tremendous interest according to environmental friendliness, ample resource, and intrinsic biocompatibility for broad applications. In this realm, both uncontrollable keratin fibril assembly procedure and resultant insufficient mechanical strength, have greatly hindered their large‐scale manufacture and commercial viability. Herein, a continuous wet‐spinning strategy is put forward to rebuild wool keratin into compact regenerated bio‐fibers with improved strength via disulfide re‐bonding. Dithiothreitol (DTT) has been introduced to renovate disulfide linkage inside keratin polypeptide chains, and bridge keratin fibrils via covalent thiol bonding to form a continuous backbone as mechanical support. A thus‐derived RWKF manifests a tensile strength of 186.1 ± 7.0 MPa and Young's modulus of 7.4 ± 0.2 GPa, which exceeds those of natural wool, feathers, and regenerated wool or feather keratin fibers. The detailed wet‐spinning technical parameters, such as coagulation, oxidation, and post‐treatment, have been systematically optimized to guarantee the continuous preparation of high‐strength regenerated keratin fibers. This work offers insight into solving the concurrent challenges for continuous manufacture of regenerated protein fibers and sustainability concerns about biomass waste.
Thiourea‐Promoted Cascade Dihalogenation‐Cyclization of Cyclohexadienone‐Containing 1,6‐Enynes
Authors: Zhao Jia‐Ying , Liao Qi , Zhang Jian‐Wei , Lin Guo‐Qiang , Wang Zhengtao , Gao Dingding , Li Qing‐Hua , Tian Ping 
Published: January 2023

AbstractOrganohalogens play an important role in the drug discovery and functional materials. However, the convenient preparation of organohalogens still remains a challenging task. Herein, we report a metal‐free cascade dihalogenation‐cyclization of cyclohexadienone‐containing 1,6‐enynes in a biodegradable solvent to generate the dibrominated cis‐tetrahydrobenzofuran‐5(4H)‐ones and cis‐dihydrobenzopyran‐6(5H)‐ones respectively bearing 1,4‐dibromobut‐1‐enyl subunit in trans‐trans and trans‐cis form. A subgram‐scale experiment and several downstream transformations are presented for elaborating the synthetic utility. Moreover, the potent anticancer activity is observed against MDA‐MB‐468 cells for the corresponding products.magnified image
Drug Permeability: From the Blood–Brain Barrier to the Peripheral Nerve Barriers
Authors: Sun Yifei , Zabihi Mahmood , Li Qi , Li Xiaosi , Kim Brandon J. , Ubogu Eroboghene E. , Raja Srinivasa N. , Wesselmann Ursula , Zhao Chao 
Published: January 2023

AbstractDrug delivery into the peripheral nerves and nerve roots has important implications for effective local anesthesia and treatment of peripheral neuropathies and chronic neuropathic pain. Similar to drugs that need to cross the blood–brain barrier (BBB) and blood–spinal cord barrier to gain access to the central nervous system (CNS), drugs must cross the peripheral nerve barriers (PNBs), formed by the perineurium and blood–nerve barrier to modulate peripheral axons. Despite significant progress made to develop effective strategies to enhance BBB permeability in therapeutic drug design, efforts to enhance drug permeability and retention in peripheral nerves and nerve roots are relatively understudied. Guided by knowledge describing structural, molecular, and functional similarities between restrictive neural barriers in the CNS and peripheral nervous system, it is hypothesized that certain CNS drug delivery strategies are adaptable for peripheral nerve drug delivery. Here, the molecular, structural, and functional similarities and differences between the BBB and PNB are described, existing CNS and peripheral nerve drug delivery strategies are summarized and compared, and the potential application of selected CNS delivery strategies to improve efficacious drug entry for peripheral nerve disorders is discussed.
Unravelling and Quantifying the Biophysical– Biochemical Descriptors Governing Protein Thermostability by Machine Learning
Authors: Kumar Shashi , Duggineni Vinay Kumar , Singhania Vibhuti , Misra Swayam Prabha , Deshpande Parag A. 
Published: January 2023

AbstractAnalysis of protein thermostability is vital in protein science to aid the understanding of evolutionary aspects of organic life as well as in protein engineering for modern day industrial applications. In the present study, supervised machine learning (ML) algorithms are employed to unravel potential patterns behind protein thermostability. This computational analysis conclusively shows inverse gamma turns, VIII turns, and the propensity of cysteine (Cys) to be the most important biophysical–biochemical attributes responsible for protein thermostability. From the propensity analysis of amino acids, polar residues, specifically glutamine (Gln) and serine (Ser), and charged residues, specifically glutamic acid (Glu) and lysine (Lys), are found to favor the enhancement of protein thermostability. The study demonstrates the feasibility of assigning quantifiable descriptors of thermostability which is expected to aid protein engineering.