bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of the relationships between clinical traits and functional connectivity based on surface morphology abnormalities in bulimia nervosa
Authors: Li Weihua , Wang Miao , Wu Guowei , Wang Jiani , Li Xiaohong , Yang Zemei , Chen Qian , Yang Zhenghan , Li Zhanjiang , Zhang Peng , Tang Lirong , Wang Zhenchang 
Published: March 2023

AbstractBackgroundBulimia nervosa is a recurrent eating disorder with uncertain pathogenesis. Recently, there has been growing interest in using neuroimaging techniques to explore brain structural and functional alterations in bulimia nervosa, but the findings of previous studies have a great number of inconsistencies.MethodsHere, we collected anatomical and resting‐state functional magnetic resonance imaging data from 43 bulimia nervosa patients and 34 matched healthy controls (HCs). We applied a surface‐based morphology analysis to explore brain cortical morphology differences and a novel surface‐based functional connectivity (FC) analysis to investigate functional abnormalities. Principal component analysis was performed to analyze the behavioral data of the participants. We further analyzed the relationships between abnormalities in cortical characteristics or FC and clinical features.ResultsWe observed increased greater sulcal depth in the right superior temporal gyrus (STG) and the right medial orbitofrontal cortex (mOFC) in bulimia nervosa patients than in the HCs. Additionally, the patients exhibited increased FC between the right STG and right ventral tegmental area but decreased function between the right mOFC and right putamen, which was significantly negatively correlated with the first principal component reflecting the severity of bulimia nervosa symptom.ConclusionsOur findings provide evidence of neuroanatomical and functional abnormalities in bulimia nervosa patients. Moreover, the FC between the right mOFC and right putamen was associated with symptom severity of bulimia nervosa, which may be a neural marker and involved in the neuropathological mechanism of bulimia nervosa.
Unprotected left main occlusion: Rare but deadly
Authors: Yildiz Mehmet , Henry Timothy D. 
Published: March 2023

Key Points
A retrospective analysis from four centers in Switzerland and France found unprotected left main coronary artery occlusion (TIMI 0 and 1 Flow) was rare (0.1%) but carried a high in‐hospital mortality rate (42%). The long‐term survival of discharged patients was relatively good.
Due to the acuity and infrequency of the condition, observational studies remain the primary source of clinical guidance, acknowledging the presence of survival biases and confounding factors.
Successful timely revascularization with percutaneous coronary intervention continues to be the preferred management.
Combined ascending aortobiiliac bypass and endovascular obliteration in the Bentall procedure for dual aortic aneurysms
Authors: Long Yanli , He Bihui , Tsao Naiwen , Liu Hongyan 
Published: March 2023

AbstractPatients with Marfan syndrome who present with a dual aortic aneurysm are not uncommon in clinical practice; however, the management of these patients is a significant challenge. We present a unique case of aortic root aneurysm and challenging infrarenal abdominal aortic aneurysm (AAA) with a short and angulated neck. We performed simultaneous repair using the Bentall procedure and ascending aortobiiliac bypass. Endovascular obliteration of the AAA neck and bilateral common iliac arteries was also performed. The perioperative process was uneventful. Normal functioning of the mechanical valve and complete thrombosis of the AAA sac were confirmed on follow‐up computed tomography and echocardiography. This report suggests that combined ascending aortobiiliac bypass and endovascular obliteration with the Bentall procedure for dual aortic aneurysm is a useful surgical strategy for patients with Marfan syndrome. Life‐long follow‐up and medication ought to be mandatory to prevent incomplete exclusion and bypass occlusion.
Clinical outcomes of left atrial appendage occlusion in patients with previous intracranial or gastrointestinal bleeding: Insights from the LOGIC (Left atrial appendage Occlusion in patients with Gastrointestinal or IntraCranial bleeding) International Multicenter Registry
Authors: Gallo Francesco , Ronco Federico , D'Amico Gianpiero , Della Rocca Domenico G. , Mazzone Patrizio , Bordignon Stefano , Casu Gavino , Giannini Francesco , Berti Sergio , Horton Rodney P. , D'Angelo Giuseppe , Urbanek Lukas , Merella Pierluigi , Ruggiero Rossella , Romeo Maria Rita , Bosica Francesco , Schmidt Boris , Atzori Enrico , Barbierato Marco , Natale Andrea , Themistoclakis Sakis 
Published: March 2023

AbstractAimsTo compare outcomes of patients who underwent left atrial appendage occlusion (LAAO) for nonvalvular atrial fibrillation (NVAF) and contraindication to anticoagulants due to history of either gastrointestinal (GI) or intracranial (IC) bleeding.MethodsPatients with NVAF that underwent LAAO for GI or IC bleeding from seven centers were included in this observational study. Baseline characteristics, procedural features, and follow‐up data were collected, and compared between the two groups. The primary outcomes were incidence of ischemic and hemorrhagic events at 12‐month.ResultsSix hundred twenty‐eight patients were included, 57% with previous GI‐bleeding, and 43% with previous IC‐bleeding. Median CHA 2 DS 2‐VASc score was 4 (interquartile range [IQRs]: 3–5) for both GI‐bleeding and IC‐bleeding patients, while GI‐bleeding patients had a higher HAS‐BLED score (4 [IQRs: 3–4] vs. 3 [IQRs]: 2–3]; p = 0.001). At 12‐month follow‐up, relative risk reduction for stroke was similar between the two groups. The GI‐bleeding group had more hemorrhagic events compared to IC‐bleeding group (any bleeding 8.4% vs. 3.2%; p = 0.012; major bleeding BARC 3–5: 4.3% vs. 1.8; p = 0.010). At multivariate analysis history of GI bleeding was an independent predictor of hemorrhagic events (adjusted HR: 2.39, 95% confidence interval: 1.02–5.63; p = 0.047).ConclusionsOutcomes after LAAO may be affected by the different indications for the procedure. In our study, GI‐bleeding and IC‐bleeding as indication to LAAO differ in their baseline characteristics. LAAO confirms its efficacy in ischemic risk reduction in both groups, while GI bleeding seems to be an independent predictor of bleeding recurrence at 12 months behind the antithrombotic regimen.
Congenital hyporhinia with associated malformations: Case report of a rare congenital anomaly
Authors: Mlay Kenneth , Chussi Desderius , Mtenga Philbert , Shija Peter , Msele Angela 
Published: March 2023

AbstractCongenital hyporhinia, also known as partial arhinia, is a very rare congenital abnormality of nasal embryogenesis with unknown etiology. It is commonly associated with other craniofacial anomalies which are thought to be caused by an absent or rudimentary nose. A 3‐h‐old neonate presented to our facility with hypoplastic nasal pyramid, hypertelorism, microcephaly, and micrognathia, a case of congenital hyporhinia with associated anomalies is presented and the embryology and literature review are discussed.
Silver‐Based Terpyridine Complexes as Antitumor Agents
Authors: Gil‐Moles María , Olmos M. Elena , Monge Miguel , Beltrán‐Visiedo Manuel , Marzo Isabel , López‐de‐Luzuriaga José M. , Concepción Gimeno M. 
Published: March 2023

AbstractSilver complexes bearing substituted terpyridine or tetra‐2‐pyridinylpyrazine ligands have been prepared and structurally characterised. The study of the anticancer properties of silver complexes with this type of ligands is scarce, despite the possibilities of combining the properties of the metal and the ability of the ligands for DNA binding. Here, the antiproliferative activity, stability, CT‐DNA binding, and mechanism of cell death of these types of derivatives are studied. High cytotoxicity against different tumour cells was observed, and, more important, a great selectivity index has been detected between tumour cells and healthy lymphocytes T for some of these compounds. The CT‐DNA interaction study has shown that these derivatives are able to interact with CT‐DNA by moderate intercalation. Furthermore, cell death studies indicate that these derivatives promote the apoptosis by a mitochondrial pathway.
A Kinetic and Heat Balance Model for Anionic Batch Block Copolymerization of Styrene and Isoprene
Authors: Kandelhard Felix , Georgopanos Prokopios 
Published: March 2023

AbstractAnionic polymerization is an established process for the synthesis of well‐defined block copolymers. Due to the high reaction rates, a good knowledge of the process and its heat generation is of great importance for safe reaction control. This is to be achieved by the development and validation of a combined kinetic and heat transport model. The validation of the combined model was based on the experimentally anionic homo‐polymerization of styrene that was expanded for the block co‐polymerization of styrene and isoprene carried out in cyclohexane in batch reactors.
Application of Nanopore Single Molecule Detection Technology in Analysis of Xylan Dissolved in Ionic Liquid†
Authors: Xie Wanyi , Fang Shaoxi , Yin Bohua , Tian Rong , Liang Liyuan , He Shixuan , Wang Deqiang 
Published: March 2023

Comprehensive SummaryXylan is the most abundant hemicellulose in nature. As a new type of green organic solvent, ionic liquid shows good preservation ability for the functional groups of hemicellulose. In this paper, a single molecule detection technology based on glass nanopore was established to analyze xylan dissolved in ionic liquid. Arabino‐xylan (AX) and beech xylan (BX) are respectively taken as the representatives of heterogeneous xylan and homogeneous xylan. Firstly, unmodified glass nanopore was used to detect the dissolved xylan in ionic liquid, and then poly(ethylene imine) (PEI) was used to modify the nanopore to change the surface charge in the nanopore and further enhance the interaction between the nanopore and the xylan molecule. It was found that before and after nanopore modification, at negative voltage and low positive voltage, AX didn't generate current blocking signal. On the contrary, BX didn't generate current blocking signal at positive voltage. This phenomenon may be due to the current disturbance driven by electrophoresis and electroosmosis of xylan molecules with weak negative charge. After statistics analysis, the current blocking signal of AX showed that the modified nanopore showed multiple peaks. It indicates that heterogeneous xylan and PEI modified nanopore had stronger interaction. The results show that the nanopore detection technology can show the structural difference of heterogenous branched chain and homogeneous straight chain based on the single characteristic current blocking signal and statistical information, providing a research basis for the structural analysis of water insoluble polysaccharides.
The stage of head and neck diagnosed malignancies in COVID‐19 outbreak versus before outbreak: A retrospective study
Authors: Jahanshahi Fatemeh , Asadi Mahboobe , Movahedi Alireza 
Published: March 2023

AbstractBackgroundGlobal COVID‐19 pandemic has affected cancer care systems. Recent studies show that the number of cases diagnosed with cancer has drastically decreased compared to the same period before the pandemic. Therefore, we are confronted with delayed diagnosis of critical cancers.AimThe aim of this study is to investigate whether the stage of known cancers has been affected by delayed diagnosis and to compare the stages of head and neck cancers diagnosed during and before the pandemic.MethodsThe present study was conducted on 132 patients with malignant head and neck tumors referred to the otolaryngology, head and neck cancer department of Taleghani Hospital from 2019 to 2021. The stage of cancers was compared between two groups of patients with head and neck malignancy referred to the Otolaryngology, Head and Neck Department of the Taleghani Hospital before and during the COVID‐19 outbreak.ResultsThe results from tumor (T), nodes (N), and metastases (M) (TNM) staging (p‐value = .015) and T score (value = 0.045) showed that the stage of tumor diagnosed in patients during the COVID‐19 pandemic significantly increased compared to patients diagnosed with a tumor before pandemic.ConclusionIn the present study, it was observed that the early symptoms of malignant head and neck tumors have been neglected by patients during COVID‐19 pandemic and resulted in delayed diagnosis. This result may be explained by the fear of COVID‐19 infection in patients, which discouraged them from visiting a doctor at healthcare centers.
Statistical harmonization of everyday functioning and dementia‐related behavioral measures across nine surveys and trials
Authors: Chen Diefei , Jutkowitz Eric , Gross Alden L. 
Published: March 2023

AbstractIntroductionEfforts to harmonize measures of everyday function and dementia‐related behaviors are needed to synthesize across studies in dementia research. There have been some psychometric attempts to harmonize everyday function for secondary analysis, but far less for dementia‐related behaviors.MethodsStatistical co‐calibration was performed to generate factor scores representing everyday function and dementia‐related behaviors for participants with dementia. We evaluated convergent criterion validity of factor scores and mapped the scores onto established clinical instruments.ResultsFactor analyses of included items fit well to available data. Harmonized factors showed expected associations with the Global Clinical Dementia Rating (CDR) score, with greater impairment (higher Global CDR score) corresponding to higher (more severe) levels on factor scores.DiscussionWe used large, well‐characterized samples to derive harmonized factors representing everyday functions and dementia‐related behaviors. These harmonized factors can be used to tackle questions about dementia phenotypes which require either large samples or unique subpopulations.
Regulating droplet impact symmetry by surface engineering
Authors: Zhao Zhipeng , Li Huizeng , Liu Quan , Li An , Xue Luanluan , Yuan Renxuan , Yu Xinye , Li Rujun , Deng Xiao , Song Yanlin 
Published: March 2023

AbstractDroplet impact on solid surfaces is essential both in nature and industry. Precisely regulating the dynamic behavior of droplet impact is of great significance for energy harvesting, anti‐icing, inkjet printing, pesticide spraying, and many other fields. Various rebounding behaviors (deposition, rebounding, rotation, instability control, and so on) and rebounding intrinsic parameters (such as contact time) after droplets impacting on solid surfaces can be regulated by surface engineering. This paper reviews the advances in regulating droplet impact behavior from the perspective of symmetry by modifying solid surfaces from the following aspects: chemical modification and physical structure regulation, in which the symmetry is discussed from mirror symmetry and rotational symmetry. Firstly, the symmetry of the droplet impact dynamics and its influencing factors are introduced. Then the modulation of droplet impact symmetry, using homogeneous and heterogeneous chemically modified solid surfaces, is summarized. The following presents the influence of physical structures, from micro to macro scale compared to the droplet size, on the droplet impact symmetry. Finally, the future challenges and opportunities of the droplet impact behavior regulation are discussed.
Climate and fire impacts on tree recruitment in mixed conifer forests in northwestern Mexico and California
Authors: Stephens Scott L. , Steel Zachary L. , Collins Brandon M. , Fry Danny L. , Gill Samantha J. , Rivera‐Huerta Hiram , Skinner Carl N. 
Published: March 2023

AbstractFrequent‐fire forests were once heterogeneous at multiple spatial scales, which contributed to their resilience to severe fire. While many studies have characterized historical spatial patterns in frequent‐fire forests, fewer studies have investigated their temporal dynamics. We investigated the influences of fire and climate on the timing of conifer recruitment in old‐growth Jeffrey pine‐mixed conifer forests in the Sierra San Pedro Martir (SSPM) and the eastern slope of the Sierra Nevada. Additionally, we evaluated the impacts of fire exclusion and recent climate change on recruitment levels using statistical models with realized as well as fire suppression and climate change‐free counterfactual scenarios. Excessive soil drying from anthropogenic climate change resulted in diminished recruitment in the SSPM but not in the Sierra Nevada. Longer fire‐free intervals attributable to fire suppression and exclusion resulted in greater rates of recruitment across all sites but was particularly pronounced in the Sierra Nevada, where suppression began >100 years ago and recruitment was 28 times higher than the historical fire return interval scenario. This demonstrates the profound impact of fire's removal on tree recruitment in Sierra Nevada forests even in the context of recent climate change. Tree recruitment at the SSPM coincided with the early‐20th‐century North American pluvial, as well as a fire‐quiescent period in the late 18th and early 19th centuries. Episodic recruitment occurred in the SSPM with no “average” recruitment over the last three centuries. We found that temporal heterogeneity, in conjunction with spatial heterogeneity, are critical components of frequent‐fire‐adapted forests. Episodic recruitment could be a desirable characteristic of frequent‐fire‐adapted forests, and this might be more amenable to climate change impacts that forecast more variable precipitation patterns in the future. One key to this outcome would be for frequent fire to continue to shape these forests versus continued emphasis on fire suppression in California.
Spatial and temporal non‐stationarity in long‐term population dynamics of over‐wintering birds of North America
Authors: Murphy Stephen J. , Jarzyna Marta A. 
Published: March 2023

AbstractUnderstanding population changes across long time scales and at fine spatiotemporal resolutions is important for confronting a broad suite of conservation challenges. However, this task is hampered by a lack of quality long‐term census data for multiple species collected across large geographic regions. Here, we used century‐long (1919–2018) data from the Audubon Christmas Bird Count (CBC) survey to assess population changes in over 300 avian species in North America and evaluate their temporal non‐stationarity. To estimate population sizes across the entire century, we employed a Bayesian hierarchical model that accounts for species detection probabilities, variable sampling effort, and missing data. We evaluated population trends using generalized additive models (GAMs) and assessed temporal non‐stationarity in the rate of population change by extracting the first derivatives from the fitted GAM functions. We then summarized the population dynamics across species, space, and time using a non‐parametric clustering algorithm that categorized individual population trends into four distinct trend clusters. We found that species varied widely in their population trajectories, with over 90% of species showing a considerable degree of spatial and/or temporal non‐stationarity, and many showing strong shifts in the direction and magnitude of population trends throughout the past century. Species were roughly equally distributed across the four clusters of population trajectories, although grassland, forest, and desert specialists more commonly showed declining trends. Interestingly, for many species, region‐wide population trends often differed from those observed at individual sites, suggesting that conservation decisions need to be tailored to fine spatial scales. Together, our results highlight the importance of considering spatial and temporal non‐stationarity when assessing long‐term population changes. More generally, we demonstrate the promise of novel statistical techniques for improving the utility and extending the temporal scope of existing citizen science datasets.
A persistent influence of supernovae on biodiversity over the Phanerozoic
Authors: Svensmark Henrik 
Published: March 2023

AbstractIt is an open question what has constrained macroevolutionary changes in marine animal diversity on the time scale of the Phanerozoic. Here, we will show that supernovae appear to have significantly influenced the biodiversity of life. After normalizing diversity curves of major animal marine genera by the changes in the area of shallow marine margins, a close correlation between supernovae frequency and biodiversity is obtained. The interpretation is that supernovae influence Earth's climate, which controls the ocean and atmospheric circulation of nutrients. With this, supernovae influence ocean bioproductivity and are speculated to affect genera‐level diversity. The implication is a surprisingly influential role of stellar processes on evolution.
Arctic nekton uncovered by eDNA metabarcoding: Diversity, potential range expansions, and pelagic‐benthic coupling
Authors: Merten Véronique , Puebla Oscar , Bayer Till , Reusch Thorsten B. H. , Fuss Janina , Stefanschitz Julia , Metfies Katja , Stauffer Julian B. , Hoving Henk‐Jan 
Published: March 2023

AbstractThe Arctic Ocean is home to a unique fauna that is disproportionately affected by global warming but that remains under‐studied. Due to their high mobility and responsiveness to global warming, cephalopods and fishes are good indicators of the reshuffling of Arctic communities. Here, we established a nekton biodiversity baseline for the Fram Strait, the only deep connection between the North Atlantic and Arctic Ocean. Using universal primers for fishes (12S) and cephalopods (18S), we amplified environmental DNA (eDNA) from seawater (50–2700 m) and deep‐sea sediment samples collected at the LTER HAUSGARTEN observatory. We detected 12 cephalopod and 31 fish taxa in the seawater and seven cephalopod and 28 fish taxa in the sediment, including the elusive Greenland shark (Somniosus microcephalus). Our data suggest three fish (Mallotus villosus, Thunnus sp., and Micromesistius poutassou) and one squid (Histioteuthis sp.) range expansions. The detection of eDNA of pelagic origin in the sediment also suggests that M. villosus, Arctozenus risso, and M. poutassou as well as gonatid squids are potential contributors to the carbon flux. Continuous nekton monitoring is needed to understand the ecosystem impacts of rapid warming in the Arctic and eDNA proves to be a suitable tool for this endeavor.
Effects of sowing methods on nitrogen compounds and protease activities of whole‐crop wheat silage
Authors: Xu Liuxing , Tang Guojian , Wu Dan , Zhang Jianguo 
Published: March 2023

AbstractBackgroundWhole‐crop wheat (Triticum aestivum) has high nutritive value, and it has become one of the main sources of roughage for ruminants in some countries or regions. This study investigates the effects of no tillage on nitrogen compounds and protease activities of whole‐crop wheat silage.MethodsWheat was planted on the 9th day (NB9) and 5th day (NB5) before rice harvest and on the first day after rice harvest. Sowing before harvest involved no tillage and sowing after rice harvest involved either no tillage (NA1) or conventional tillage (CK).ResultsCompared to CK, the crude protein content of NB9 and NB5 decreased by 16.4% and 9.58%, respectively. With the delay of the sowing date, the contents of non‐protein nitrogen, rapidly degraded protein, and slowly degraded protein in whole‐plant wheat tended to increase. Compared to NA1 wheat silage, the NH3‐N content of NB9 and NB5 silages decreased by 52.7% and 34.4%, respectively. The acid protease activity of NA1 was significantly higher than that of other treatments (p < 0.05).ConclusionsThere was no significant difference in the degree of protein degradation between NA1 and CK silages. Although the degree of protein degradation in early sowing was low, the degree of fermentation was also weak.