bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virus infection participates in the occurrence and development of human diseases through monoamine oxidase
Authors: Sun Yujie , Liu Wen , Luo Bing 
Published: June 2023

AbstractMonoamine oxidase (MAO) is a membrane‐bound mitochondrial enzyme that maintains the steady state of neurotransmitters and other biogenic amines in biological systems through catalytic oxidation and deamination. MAO dysfunction is closely related to human neurological and psychiatric diseases and cancers. However, little is known about the relationship between MAO and viral infections in humans. This review summarises current research on how viral infections participate in the occurrence and development of human diseases through MAO. The viruses discussed in this review include hepatitis C virus, dengue virus, severe acute respiratory syndrome coronavirus 2, human immunodeficiency virus, Japanese encephalitis virus, Epstein‐Barr virus, and human papillomavirus. This review also describes the effects of MAO inhibitors such as phenelzine, clorgyline, selegiline, M‐30, and isatin on viral infectious diseases. This information will not only help us to better understand the role of MAO in the pathogenesis of viruses but will also provide new insights into the treatment and diagnosis of these viral diseases.
FastFusion: Deep stereo‐LiDAR fusion for real‐time high‐precision dense depth sensing
Authors: Meng Haitao , Li Changcai , Zhong Chonghao , Gu Jianfeng , Chen Gang , Knoll Alois 
Published: June 2023

AbstractLight detection and ranging (LiDAR) and stereo cameras are two generally used solutions for perceiving 3D information. The complementary properties of these two sensor modalities motivate a fusion to derive practicable depth sensing toward real‐world applications. Promoted by deep neural network (DNN) techniques, recent works achieve superior performance on accuracy. However, the complex architecture and the sheer number of DNN parameters often lead to poor generalization capacity and non‐real‐time computing. In this paper, we present FastFusion, a three‐stage stereo‐LiDAR deep fusion scheme, which integrates the LiDAR priors into each step of classical stereo‐matching taxonomy, gaining high‐precision dense depth sensing in a real‐time manner. We integrate stereo‐LiDAR information by taking advantage of a compact binary neural network and utilize the proposed cross‐based LiDAR trust aggregation to further fuse the sparse LiDAR measurements in the back‐end of stereo matching. To align the photometrical of the input image and the depth of the estimation, we introduce a refinement network to guarantee consistency. More importantly, we present a graphic processing unit‐based acceleration framework for providing a low‐latency implementation of FastFusion, gaining both accuracy improvement and real‐time responsiveness. In the experiments, we demonstrate the effectiveness and practicability of FastFusion, which obtains a significant speedup over state‐of‐the‐art baselines while achieving comparable accuracy on depth sensing. The video demo for real‐time depth estimation of FastFusion on the real‐world driving scenario is available at https://youtu.be/nP7cls2BA8s.
Potential interference of organic acids and ferrous iron in the interpretation of Fe and Mn indicators of reduction in soil
Authors: Loffredo Joseph A. , Rabenhorst Martin C. , Stolt Mark H. , Amador Jose A. 
Published: June 2023

AbstractRemoval of manganese (Mn) and iron (Fe) oxide coatings from indicators of reduction in soil (IRIS) is considered a function of microbial reduction of these elements under sufficiently reducing conditions, but there may be situations where removal is abiotic. We examined whether abiotic removal of Mn and Fe oxide coatings may be facilitated by organic acids and whether loss of Mn can take place via chemical reduction by ferrous iron (Fe2+) in vitro. Loss of color from Mn‐IRIS in citric acid solution was highest at 1 and 10 mM regardless of pH, with no loss observed at lower concentrations. Effects of citric acid on Fe‐IRIS were also limited to 1 and 10 mM, but color loss only occurred at pH 4.5 and the rate and extent of loss were lower than for Mn‐IRIS. Color loss from Mn‐IRIS in oxalic acid was highest at 1 and 10 mM and increased with decreasing pH. Effects of oxalic acid on loss of color from Fe‐IRIS were limited to 1 and 10 mM. Loss of color from Mn‐IRIS was limited to 10 mM salicylic acid and pH 4.5, with no effect on Fe‐IRIS regardless of concentration and pH. Only the two highest concentrations of Fe2+(50 and 100 mM) resulted in reduction of the Mn‐IRIS coating and subsequent deposition of an Fe oxide coating. Organic acids and pH have a differential effect on color loss from Mn‐ and Fe‐IRIS, with only high concentrations of organic acids at low pH possibly interfering with interpretation.
Fabrication, Characterization and Therapeutic Evaluation of Fluoxetine‐Dextran Nanoparticles
Authors: Naz Asia , Hashim Faiza , Ali Syed Abid , Badshah Munair 
Published: June 2023

AbstractIn recent times conventional dosage forms face a number of challenges, i. e., adverse effects, low absorption of drugs, and delivery at the targeted sites for desired therapeutic effect. In the current study, dextran‐fluoxetine nanoconjugates were prepared, characterized, and evaluated for therapeutic efficacy. Dextran was oxidized via aldehyde functional group subsequently conjugated with fluoxetine using Schiff based reaction. Characterization techniques like ultra‐violet spectroscopy, Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and circular dichroism spectroscopy confirmed successful drug‐polymer conjugation. Nanoconjugates size and shape was assessed using dynamic light scattering and atomic force microscopy respectively, whereas thermo‐gravimetric analysis revealed the stability. Drug loading was found 21 %, whereas the drug release for 48 h showed 28 % release at pH=5 and 16 % at pH=7.4. Anticancer activity of the nanoparticles was assessed using HeLa cell lines and revealed 99.5 % cellular inhibition whereas cytotoxic assay was done using healthy cell line 3T3 showing 14.6 % cell inhibition. This study showed controlled release of drugs from the nanoparticles in the simulated conditions and has potential to reduce associated adverse effects. It is hypothesized that these nanoparticles may find application in anticancer drugs‐controlled release with reduced toxicities.
Synthesis of Ag−/Graphene Aerogel Composite for Removal of Methyl Orange
Authors: Xuan Trinh Truong Thi Phuong Nguyet , Mong Thy Lu Thi , That Buu Ton , Duy Hai Nguyen , An Hoang , Hoai Nam Nguyen Thanh , Hoang Lin Tong , Gia Phu Lam Dinh , Hien Le Viet , Minh Dat Nguyen , Thanh Phong Mai , Huu Hieu Nguyen 
Published: June 2023

AbstractIn this study, silver‐titanium dioxide/graphene aerogel (Ag−TiO2/GA−ATG) was synthesized via chemical reduction using ethylene diamine (EDA). The effects of reductant doses on the formation of the three‐dimensional structure and the photocatalytic degradation efficiency of ATG were evaluated with five different volumes (20, 30, 40, 50, and 60 μL), corresponding to the ATG1, ATG2, ATG3, and ATG4, respectively. The results showed that 40 μL of EDA was the suitable condition for the formation of ATG three‐dimensional structure. Characterizations revealed that ATG3 was successfully synthesized with distinctive peaks of Ag and TiO2 in the X‐ray diffraction patterns whilst scanning electron microscope and high resolution transmission electron microscope images showed a porous structure, silver nanoparticles and TiO2 with an average size of 10–25 nm were uniformly distributed on the graphene surface. Furthermore, ATG3 possessed the highest photocatalytic capability to deteriorate methyl orange with an efficiency of up to 99.53 % with a catalyst dose of 0.3 mg/mL, superior compared to those of TiO2 and TiO2/GA. The radicals scavenging experiments elucidated ⋅
to majorly contribute to the photodegradation process. Moreover, ATG3 showed high recyclability, which retains 80 % of yield even after 10 cycles. Those findings proved that ATG has high potential in the environmental remediation field.
Adsorption of Thorium (IV) from Aqueous Solution by Htpop Containing Active Imine
Authors: Xu Yufen , Peng Tianqiong , Liu Zengcheng , Wang Yanfei 
Published: June 2023

AbstractBis (diphenyl phosphate) imine (Htpop) was synthesized using a simple one‐step solvent method to remove thorium (IV) from aqueous solutions. The structure, functional group displacement, morphological differences, and elemental composition of the samples were analyzed using characterization techniques such as NMR, FTIR, SEM, EDS, and XPS. According to the batch experiment, when pH=4.0 and temperature was 298 K, the adsorption equilibrium can be reached within 40 min, and the adsorption capacity was 189.32 mg ⋅ g−1. The adsorption process conforms to the quasi‐second‐order kinetic model (R2=0.9959) and Langmuir model (R2=0.9971). Thermodynamic data (▵H0<0, ▵G0<0) indicate that the adsorption behavior of thorium (IV) in Htpop was spontaneous and exothermic.
Coal Fly Ash‐based P Zeolite‐anchored CuxO as an Efficient Catalyst for Heterogeneous Photo‐Fenton Degradation of Methylene Blue
Authors: Li Lei , Gan Simeng , Zhang Huabing , Sun Houxiang , Zhong Zicong 
Published: June 2023

AbstractThe environmental quality has been given more attention because of the potential hazards brought by urbanization and industrialization. Therefore, this study proposed a comprehensive utilization method for treating dye wastewater using solid waste. P zeolite was prepared using coal fly ash (CFA), and then anchored with CuxO as catalyst (CuxO/P) for heterogeneous Fenton‐like degradation of methylene blue (MB) under ultraviolet irradiation (UV). Compared with P zeolite and CuO, the catalyst CuxO/P showed the highest degradation efficiency of MB in combination with H2O2and UV (98.3 %) after 90 min of reaction. This can be attributed to the involvement of copper component and the dispersion of P zeolite as the carrier. The MB degradation reaction was consistent with first‐order kinetics. The sum of the rate constant k in the CuxO/P+H2O2(0.0030 min−1) and CuxO/P+UV (0.0035 min−1) system is much lower than that in the CuxO/P+H2O2+UV system (0.0491 min−1), indicating a strong synergistic effect among CuxO/P, H2O2, and UV. Meanwhile, the catalyst CuxO/P with excellent stability and renewability presented a degradation efficiency of over 95 % in 5 cycles, exhibiting considerable application prospects in dye wastewater treatment. Furthermore, the most effectively radical was ⋅OH generated by catalytic H2O2. This work provided a new perspective for the reuse of coal fly ash. It would be one of the most efficient and comprehensive utilization ways to treat wastewater with solid waste.
Self‐Assembled Microactuators Using Chiral Liquid Crystal Elastomers
Authors: Lee Yoo Jin , Abdelrahman Mustafa K. , Kalairaj Manivannan Sivaperuman , Ware Taylor H. 
Published: June 2023

AbstractMaterials that undergo reversible changes in form typically require top‐down processing to program the microstructure of the material. As a result, it is difficult to program microscale, 3D shape‐morphing materials that undergo non‐uniaxial deformations. Here, a simple bottom‐up fabrication approach to prepare bending microactuators is described. Spontaneous self‐assembly of liquid crystal (LC) monomers with controlled chirality within 3D micromold results in a change in molecular orientation across thickness of the microstructure. As a result, heating induces bending in these microactuators. The concentration of chiral dopant is varied to adjust the chirality of the monomer mixture. Liquid crystal elastomer (LCE) microactuators doped with 0.05 wt% of chiral dopant produce needle‐shaped actuators that bend from flat to an angle of 27.2 ± 11.3° at 180 °C. Higher concentrations of chiral dopant lead to actuators with reduced bending, and lower concentrations of chiral dopant lead to actuators with poorly controlled bending. Asymmetric molecular alignment inside 3D structure is confirmed by sectioning actuators. Arrays of microactuators that all bend in the same direction can be fabricated if symmetry of geometry of the microstructure is broken. It is envisioned that the new platform to synthesize microstructures can further be applied in soft robotics and biomedical devices.
Nucleic Acid Enzyme‐Activated CRISPR‐Cas12a With Circular CRISPR RNA for Biosensing
Authors: Wu Yunping , Chang Dingran , Chang Yangyang , Zhang Qiang , Liu Yi , Brennan John D. , Li Yingfu , Liu Meng 
Published: June 2023

Abstractclustered regularly interspaced short palindromic repeats (CRISPR)‐Cas systems are increasingly used in biosensor development. However, directly translating recognition events for non‐nucleic acid targets by CRISPR into effective measurable signals represents an important ongoing challenge. Herein, it is hypothesized and confirmed that CRISPR RNAs (crRNAs) in a circular topology efficiently render Cas12a incapable of both site‐specific double‐stranded DNA cutting and nonspecific single‐stranded DNA trans cleavage. Importantly, it is shown that nucleic acid enzymes (NAzymes) with RNA‐cleaving activity can linearize the circular crRNAs, activating CRISPR‐Cas12a functions. Using ligand‐responsive ribozymes and DNAzymes as molecular recognition elements, it is demonstrated that target‐triggered linearization of circular crRNAs offers great versatility for biosensing. This strategy is termed as “NAzyme‐Activated CRISPR‐Cas12a with Circular CRISPR RNA (NA3C).” Use of NA3C for clinical evaluation of urinary tract infections using an Escherichia coli‐responsive RNA‐cleaving DNAzyme to test 40 patient urine samples, providing a diagnostic sensitivity of 100% and specificity of 90%, is further demonstrated.
V4C3 MXene Immune Profiling and Modulation of T Cell‐Dendritic Cell Function and Interaction
Authors: Fusco Laura , Gazzi Arianna , Shuck Christopher E. , Orecchioni Marco , Ahmed Eiman I , Giro Linda , Zavan Barbara , Yilmazer Açelya , Ley Klaus , Bedognetti Davide , Gogotsi Yury , Delogu Lucia Gemma 
Published: June 2023

AbstractAlthough vanadium‐based metallodrugs are recently explored for their effective anti‐inflammatory activity, they frequently cause undesired side effects. Among 2D nanomaterials, transition metal carbides (MXenes) have received substantial attention for their promise as biomedical platforms. It is hypothesized that vanadium immune properties can be extended to MXene compounds. Therefore, vanadium carbide MXene (V4C3) is synthetized, evaluating its biocompatibility and intrinsic immunomodulatory effects. By combining multiple experimental approaches in vitro and ex vivo on human primary immune cells, MXene effects on hemolysis, apoptosis, necrosis, activation, and cytokine production are investigated. Furthermore, V4C3 ability is demonstrated to inhibit T cell‐dendritic cell interactions, evaluating the modulation of CD40–CD40 ligand interaction, two key costimulatory molecules for immune activation. The material biocompatibility at the single‐cell level on 17 human immune cell subpopulations by single‐cell mass cytometry is confirmed. Finally, the molecular mechanism underlying V4C3 immune modulation is explored, demonstrating a MXene‐mediated downregulation of antigen presentation‐associated genes in primary human immune cells. The findings set the basis for further V4C3 investigation and application as a negative modulator of the immune response in inflammatory and autoimmune diseases.
Wellposedness and regularity for linear Maxwell equations with surface current
Authors: Dörich Benjamin , Zerulla Konstantin 
Published: June 2023

AbstractWe study linear time-dependent Maxwell equations on a cuboid consisting of two homogeneous subcuboids. At the interface, we allow for nonzero surface charge density and surface current. This model is a first step towards a detailed mathematical analysis of the interaction of single-layer materials with electromagnetic fields. The main results of this paper provide several wellposedness and regularity statements for the solutions of the Maxwell system. To prove the statements, we employ extension arguments using interpolation theory, as well as semigroup theory and regularity theory for elliptic transmission problems.
Mode-II progressive fracture of sawn timber and timber-adhesive bond: experimental evaluation of end notched flexure (ENF) testing using DIC
Authors: Rahman Shaikh Atikur , Subhani Mahbube , Ashraf Mahmud 
Published: June 2023

AbstractThe end-notched flexure (ENF) testing technique has been used in this paper to investigate the Mode II fracture behaviour of sawn timber and timber-adhesive bonds. Mode-II strain energy release rates were obtained by using classical data reduction schemes based on actual crack lengths captured using digital image correlation (DIC) technique. The compliance-based beam method (CBBM), which does not require the actual crack length measurements, was also evaluated for its suitability for Mode-II fracture of timber. Utilizing forward shear slip measurement from DIC at every millimetre of crack length, a simple yet effective and innovative technique to identify crack tip opening and to monitor crack length has been proposed herein. Three different initial notch widths were used in the current study to examine their suitability in producing reliable crack initiation and consistent bond delamination in solid timber and glued timber. The strain energy release rates calculated from the actual crack and equivalent crack length values showed similar trends in fracture resistance curves, which are commonly known as R curves, but the initial strain energy release rate (GII0) and the critical strain energy rate (GIIC) obtained from the two methods showed some discrepancies. Equivalent crack method CBBM was found to be inadequate in determining a consistent initial strain energy release rate despite producing a stable and steady fracture energy after crack initiation. Experimental results showed that Mode-II timber-adhesive bond line fracture is relatively more brittle than timber fracture, and the average critical strain energy release rate of timber-adhesive bond (GIIc) was 14% greater than that of sawn timber. Based on experimental observations, specific test criteria for ENF testing of timber structures are proposed in this paper.
Factors associated with long-term benzodiazepine and Z-drug use across the lifespan and 5-year temporal trajectories among incident users: a Swedish nationwide register-based study
Authors: Isomura Kayoko , Wang Xinchen , Chang Zheng , Hellner Clara , Hasselström Jan , Ekheden Isabella , Jayaram-Lindström Nitya , Lichtenstein Paul , D’Onofrio Brian M. , Mataix-Cols David , Sidorchuk Anna 
Published: June 2023

Abstract
Purpose
Despite being discouraged by guidelines, long-term use of benzodiazepines and related Z-drugs (BZDR) remains frequent in the real-world. An improved understanding of factors associated with the transition from new to long-term BZDR use and of temporal BZDR use trajectories is needed. We aimed to assess the proportion of long-term BZDR use (> 6 months) in incident BZDR-recipients across the lifespan; identify 5-year BZDR use trajectories; and explore individual characteristics (demographic, socioeconomic and clinical) and prescribing-related factors (pharmacological properties of the initial BZDR, prescriber’s healthcare level, and concurrent dispensing of other medications) associated with long-term BZDR use and distinct trajectories.

Methods
Our nationwide register-based cohort included all BZDR-recipients in Sweden with first dispensation in 2007–2013. Trajectories of BZDR use days per year were built using group-based trajectory modelling. Cox regression and multinomial logistic regression were fitted to assess the predictors of long-term BZDR use and trajectories’ membership.

Results
In 930,465 incident BZDR-recipients, long-term use increased with age (20.7%, 41.0%, and 57.4% in 0–17, 18–64, and ≥ 65-year-olds, respectively). Four BZDR use trajectories emerged, labelled ‘discontinued’, ‘decreasing’, ‘slow decreasing’ and ‘maintained’. The proportion of the ‘discontinued’ trajectory members was the largest in all ages, but reduced from 75.0% in the youths to 39.3% in the elderly, whereas the ‘maintained’ increased with age from 4.6% to 36.7%. Prescribing-related factors, in particular multiple BZDRs at initiation and concurrent dispensing of other medications, were associated with increased risks of long-term (vs short-term) BZDR use and developing other trajectories (vs ‘discontinued’) in all age groups.

Conclusions
The findings highlight the importance of raising awareness and providing support to prescribers to make evidence-based decisions on initiating and monitoring BZDR treatment across the lifespan.
Impact of left atrial appendage occlusion device position on potential determinants of device-related thrombus: a patient-specific in silico study
Authors: Zhong Zhaoyang , Gao Yiting , Kovács Soma , Vij Vivian , Nelles Dominik , Spano Lukas , Nickenig Georg , Sonntag Simon , De Backer Ole , Søndergaard Lars , Sedaghat Alexander , Mela Petra 
Published: June 2023

Abstract
Background
Device-related thrombus (DRT) after left atrial appendage occlusion (LAAO) is potentially linked to adverse events. Although clinical reports suggest an effect of the device type and position on the DRT risk, in-depth studies of its mechanistic basis are needed. This in silico study aimed to assess the impact of the position of non-pacifier (Watchman) and pacifier (Amulet) LAAO devices on surrogate markers of DRT risk.

Methods
The LAAO devices were modeled with precise geometry and virtually implanted in different positions into a patient-specific left atrium. Using computational fluid dynamics, the following values were quantified: residual blood, wall shear stress (WSS) and endothelial cell activation potential (ECAP).

Results
In comparison to an ostium-fitted device position, deep implantation led to more residual blood, lower average WSS and higher ECAP surrounding the device, especially on the device’s atrial surface and the surrounding tissue, suggesting increased risk for potential thrombus. For the non-pacifier device, an off-axis device orientation resulted in even more residual blood, higher ECAP and similar average WSS as compared to an ostium-fitted device position. Overall, the pacifier device showed less residual blood, higher average WSS and lower ECAP, compared to the non-pacifier device.

Conclusions
In this in silico study, both LAAO device type and implant position showed an impact on potential markers of DRT in terms of blood stasis, platelet adhesion and endothelial dysfunction. Our results present a mechanistic basis for clinically observed risk factors of DRT and the proposed in silico model may aid in the optimization of device development and procedural aspects.

Graphical abstract
Gallic acid derivatives as stabilizers in cellulose solutions: analysis by 31P NMR spectroscopy
Authors: Zieher Johanna , Melikhov Ivan , Bacher Markus , Hettegger Hubert , Potthast Antje , Rosenau Thomas 
Published: June 2023

AbstractLyocell dopes for cellulosic fiber manufacture, i.e., cellulose solutions in N-methylmorpholine-N-oxide monohydrate, are commonly stabilized by propyl gallate, or alternatively by recently proposed gallic acid amide derivatives. In this study, the analysis of the stabilizer and its major degradation products, ellagic acid and ellagoquinone, is investigated. The stabilizer-derived compounds are readily extracted from the dopes with polar aprotic solvents without solvent or cellulose interference. This is followed by the derivatization of the OH groups with a phosphitylation agent and subsequent 31P NMR analysis—an approach frequently used to differentiate and quantify OH groups in lignins. The chemical shifts of the resulting phosphites are reported and structures of the stabilizer derivatives are discussed. The 31P NMR approach offers a straightforward way to analyze the stabilizer chemistry in the Lyocell process.
Graphical abstract