bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acetic acid positively modulates proline metabolism for mitigating PEG-mediated drought stress in Maize and Arabidopsis
Authors: Mahmud Sakil , Kamruzzaman Mohammad , Bhattacharyya Sabarna , Alharbi Khadiga , Abd El Moneim Diaa , Mostofa Mohammad Golam 
Published: July 2023

IntroductionOsmotic imbalance is one of the major consequences of drought stress, negatively affecting plant growth and productivity. Acetic acid has modulatory roles in osmotic balance in plants; however, the mechanistic insights into acetic acid-mediated osmotic adjustment under drought stress remains largely unknown.MethodsHere, we investigated how seed priming and seedling root treatment with acetic acid enabled maize plants overcoming polyethylene glycol (PEG)-induced drought effects.ResultsMaize seeds primed with acetic acid showed better growth performance when compared with unprimed seeds under PEG application. This growth performance was mainly attributed to improved growth traits, such as fresh weight, dry weight, length of shoots and roots, and several leaf spectral indices, including normalized difference vegetation index (NDVI) and chlorophyll absorption in reflectance index (MCARI). The levels of oxidative stress indicators hydrogen peroxide (H2O2) and malondialdehyde (MDA) did not alter significantly among the treatments, but proline content as well as the expression of proline biosynthetic gene, Δ1-PYRROLINE-5-CARBOXYLATE SYNTHETASE 1 (P5CS1) was significantly elevated in plants receiving acetic acid under PEG-treatments. On the other hand, treating the seedlings root with acetic acid led to a significant recovery of maize plants from drought-induced wilting. Although growth traits remained unchanged among the treatments, the enhancement of leaf water content, photosynthetic rate, proline level, expression of P5CS1, and antioxidant enzyme activities along with reduced level of H2O2 and MDA in acetic acid-supplemented drought plants indicated a positive regulatory role of acetic acid in maize tolerance to drought. Moreover, the high expression of P5CS1 and the subsequent elevation of proline level upon acetic acid application were further validated using wild type and proline biosynthetic mutant p5cs1 of Arabidopsis. Results showed that acetic acid application enabled wild type plants to maintain better phenotypic appearance and recovery from drought stress than p5cs1 plants, suggesting a crosstalk between acetic acid and proline metabolism in plants under drought stress.DiscussionOur results highlight the molecular and intrinsic mechanisms of acetic acid conferring plant tolerance to drought stress.
Effects of physical activity combined with different visual target presentation durations of ciliary-muscle training on visual acuity in children
Authors: Zhou Sheng , Zhang Meng , Zheng Wenbin , Yin Rongbin , Chen Gang 
Published: July 2023

PurposeThis study aimed to identify the effect of different durations of visual target presentation during ciliary-muscle training on children's kinetic visual acuity (KVA), uncorrected distance visual acuity (UDVA), axial length, and accommodative facility.MethodsBased on the ciliary-muscle regulation mechanism, an intervention program involving ciliary-muscle training with different durations of visual target presentation combined with physical education classes was designed. The intervention aimed to determine the effect of different ciliary-muscle training durations on children's visual acuity. A total of 153 children aged 10–11 years from a school in Suzhou (a major city located in southeastern Jiangsu Province, East China) were enrolled as participants in this 32-week intervention study. This study measured the participants' UDVA and KVA before, during (after the 16th week), and after (after the 32nd week) the experimental intervention. The accommodative facility was measured during and after the intervention.ResultsAfter 32 weeks of the intervention, the KVA and UDVA of each experimental group were significantly improved (p &lt; 0.05). A high percentage in the improvement of KVA was observed in the 3-s and 1-s groups (25.53%, 21.74%), and the highest percentage in the improvement of UDVA was observed in the 3-s group (2.96%). Axial length increased significantly in all groups (p &lt; 0.05), and there was a low percentage increase in the 1-s and 3-s groups (0.82%). The accommodative facility was significantly improved in all experimental groups, with a higher improvement percentage in the 3-s and 1-s groups (3.01% and 2.61%, respectively). After dividing the children in each group according to their visual acuity, the KVA of children in the 1-s group was significantly improved, the UDVA of children with myopia was significantly increased, and the accommodative facility of children with mild and moderate myopia was significantly improved. Moreover, the KVA, UDVA, and accommodative facility of children with mild and moderate myopia in the 3-s group were significantly improved. The KVA of children with emmetropia and the accommodative facility of children with mild and moderate myopia in the 5-s group were also significantly increased.ConclusionIn school physical education classes, the 1-s, 3-s, and 5-s ciliary-muscle regulating exercise could effectively improve the kinetic visual acuity, uncorrected distance visual acuity, and accommodative facility of children aged 10–11 years. Among them, the effects of the 1-s and 3-s durations are better than that of the 5-s duration, as it can reduce the growth rate of axial length and achieve better effects among children with mild and moderate myopia.
Using human-in-the-loop optimization for guiding manual prosthesis adjustments: a proof-of-concept study
Authors: Senatore Siena C. , Takahashi Kota Z. , Malcolm Philippe 
Published: July 2023

Introduction: Human-in-the-loop optimization algorithms have proven useful in optimizing complex interactive problems, such as the interaction between humans and robotic exoskeletons. Specifically, this methodology has been proven valid for reducing metabolic cost while wearing robotic exoskeletons. However, many prostheses and orthoses still consist of passive elements that require manual adjustments of settings.Methods: In the present study, we investigated if human-in-the-loop algorithms could guide faster manual adjustments in a procedure similar to fitting a prosthesis. Eight healthy participants wore a prosthesis simulator and walked on a treadmill at 0.8 ms−1 under 16 combinations of shoe heel height and pylon height. A human-in-the-loop optimization algorithm was used to find an optimal combination for reducing the loading rate on the limb contralateral to the prosthesis simulator. To evaluate the performance of the optimization algorithm, we used a convergence criterium. We evaluated the accuracy by comparing it against the optimum from a full sweep of all combinations.Results: In five out of the eight participants, the human-in-the-loop optimization reduced the time taken to find an optimal combination; however, in three participants, the human-in-the-loop optimization either converged by the last iteration or did not converge.Discussion: Findings from this study show that the human-in-the-loop methodology could be helpful in tasks that require manually adjusting an assistive device, such as optimizing an unpowered prosthesis. However, further research is needed to achieve robust performance and evaluate applicability in persons with amputation wearing an actual prosthesis.
Designing virtual reality exposure scenarios to treat anxiety in people with epilepsy: Phase 2 of the AnxEpiVR clinical trial
Authors: Lewis-Fung Samantha , Tchao Danielle , Gray Hannah Gabrielle , Nguyen Emma , Pardini Susanna , Harris Laurence R. , Calabia Dale , Appel Lora 
Published: July 2023

Introduction: Anxiety in people with epilepsy (PwE) is characterized by distinct features related to having the condition and thus requires tailored treatment. Although virtual reality (VR) exposure therapy is widely-used to treat a number of anxiety disorders, its use has not yet been explored in people with epilepsy. The AnxEpiVR study is a three-phase pilot trial that represents the first effort to design and evaluate the feasibility of VR exposure therapy to treat epilepsy-specific interictal anxiety. This paper describes the results of the design phase (Phase 2) where we created a minimum viable product of VR exposure scenarios to be tested with PwE in Phase 3.Methods: Phase 2 employed participatory design methods and hybrid (online and in-person) focus groups involving people with lived experience (n = 5) to design the VR exposure therapy program. 360-degree video was chosen as the medium and scenes were filmed using the Ricoh Theta Z1 360-degree camera.Results: Our minimum viable product includes three exposure scenarios: (A) Social Scene—Dinner Party, (B) Public Setting—Subway, and (C) Public Setting—Shopping Mall. Each scenario contains seven 5-minute scenes of varying intensity, from which a subset may be chosen and ordered to create a customized hierarchy based on appropriateness to the individual’s specific fears. Our collaborators with lived experience who tested the product considered the exposure therapy program to 1) be safe for PwE, 2) have a high level of fidelity and 3) be appropriate for treating a broad range of fears related to epilepsy/seizures.Discussion: We were able to show that 360-degree videos are capable of achieving a realistic, immersive experience for the user without requiring extensive technical training for the designer. Strengths and limitations using 360-degree video for designing exposure scenarios for PwE are described, along with future directions for testing and refining the product.
PENGARUH PENERAPAN MODEL PROBLEM BASED LEARNING BERBANTUAN MEDIA AUDIO VISUAL TERHADAP HASIL BELAJAR SUBTEMA PELESTARIAN KEKAYAAN SUMBER DAYA ALAM DI INDONESIA
Authors: Yovani Christin Natalia Purba  , Yuyun Elizabeth Patras  , Yuli Mulyawati  
Published: July 2023

This research aims to determine the Effect of the Application of Problem Based Learning Models Assisted by Audio Visual Media on Learning Outcomes of the Subtheme of Preservation of Natural Resources Wealth inIndonesia. This research was carried out at SDN Bantarjati 8 Bogor City for the 2022/2023 academic year. This research is with a two-class type of quasi-design experimental research. The subject of this study was class IV SDN Bantarjati 8 Bogor City consisting of 58 students. Data collection carried out to obtain learning outcomes was obtained using Pretest and Postest. This study also used the as normality test with the liliefors test. The results showed thatthe results were normally distributed because the values of both samples were smaller than the Ltable. in the experimental class group L count < L table, which is 0.048 < 0.161, in the control class L calculate < Ltable, which is 0.025 < 0.161. Furthermore, the result of the hypothesis test states that Ho is rejected and Ha (alternative hypothesis) is accepted because the value of t is calculated (4.89297) > ttable (2.00324) with dk 56 and significance level 0.05 (5%). Thus, there is an influence on the application of the Problem Based Learning model Assisted by Audio Visual Media on the learning outcomes of the subtheme of Preservation of Natural Resource Wealth in Indonesia in class IV SDN Bantarjati 8 Bogor City Even Semester of the 2022/2023 Academic Year.
The Chemical Composition of Helvine-Group Minerals and Implications for Ore Genesis: Case Studies from the Dawan, Qidushan, and Taoxikeng Deposits
Authors: Zhu Yiting , Li Xiaofeng , Wei Xinglin 
Published: July 2023

Abstract
Helvine-group minerals have characteristic chemical compositions and textures and occur in different environments within magmatic–hydrothermal deposits. However, their origin is still unclear. There are several quartz-vein beryllium deposits with different element assemblages existing in southeastern China; these include the Dawan Be-Mo, Qidushan Be-Zn-Sn, and Taoxikeng Be-W deposits. We present the chemical composition of helvine-group minerals analyzed by electron probe microanalysis and laser ablation inductively coupled plasma mass spectrometry, in addition to zircon sensitive high-mass-resolution ion microprobe U-Pb and cassiterite laser ablation inductively coupled plasma mass spectrometry U-Pb ages. The zircon and cassiterite U-Pb data indicate that the Qidushan deposit formed during the Late Cretaceous (127–132 Ma). The electron probe microanalysis data show that the helvine-group minerals from the three deposits are helvine and/or danalite. A wide variety of different trace elements display high concentrations in the different deposits [e.g., helvine-group minerals from the Dawan deposit are rich in Li, B, Sc, V, Ga, Y, Sn, Cs, Th, and U; those from the Qidushan deposit are rich in Sc, Cd, and Sn; whereas those from the Taoxikeng deposit are rich in Y, Cd, Sn, Ta, and total rare-earth elements (ΣREE). The material analyzed from the Dawan deposit has the highest concentrations of Li (28.03–134.96 ppm), Sn (126.01–709.24 ppm), Sc (108.10–287.64 ppm), Cs (0–37.24 ppm), Th (4.78–112.63 ppm), and U (0.79–4.13 ppm). The material analyzed from the Taoxikeng deposit has the highest concentrations of Y (594.95–899.95 ppm), Cd (22.63–25.21 ppm), Ta (0.41–0.86 ppm), and ΣREE (281.69–451.79 ppm). However, those from the Qidushan deposit have the lowest concentrations of Y (10.21–37.70 ppm), Sn (0–26.88 ppm), U (0–19.06 ppm), Eu (0–0.14 ppm), and Cs (being below the detection limit). All of them are rich in heavy REEs but poor in light REEs, with distinctive REE patterns. Our results reveal that both crystallographic substitution and fluid composition control the enrichment of trace elements in helvine-group minerals. The textures and trace element compositions of helvine-group minerals can represent various parageneses and ore-forming fluid compositions. We propose that the δEu values and (La/Yb)N ratios can be used as markers to discriminate the genesis of helvine-group mineral precipitated from different environments based on the chemical compositions and the origin of ore-forming fluids.
Les cinq sens au Moyen Âge : État de la question et perspectives de recherche
Authors: Palazzo Éric 
Published: July 2023

Le présent article propose en premier lieu une synthèse complète de la bibliographie et de l’historiographie des recherches sur les cinq sens au Moyen Âge. Dans cette synthèse, les principaux travaux des médiévistes sur les cinq sens sont passés en revue ainsi que ceux émanant de philosophes, d’anthropologues et de sociologues. La première partie de l’article vise également à dégager les grands thèmes de la recherche sur les cinq sens dans les sciences humaines tout au long du xxe siècle et de poser les bases d’une réflexion nouvelle sur la place des cinq sens dans la définition de la liturgie chrétienne médiévale et du rôle de l’activation de l’art dans la pratique des rituels. La seconde partie de l’article ouvre des pistes de recherche nouvelles pour saisir la façon dont les cinq sens constituent des éléments majeurs de la définition de la liturgie médiévale. Pour ce faire, l’attention est portée sur le concept de synesthésie dont l’origine remonte à saint Augustin, du moins en perspective chrétienne, et qui joue un rôle majeur dans la théologie de la liturgie. À la suite de quoi, une approche nouvelle de l’art dans la liturgie est rendue possible à partir de l’idée de l’activation sensorielle des images du lieu de culte et des objets liturgiques destinée à rendre réellement présente la synesthésie dans le rituel. Au final, ces recherches nouvelles sur les cinq sens dans la liturgie et dans l’art médiéval permettent de mieux cerner des notions fondamentales de la théologie chrétienne, telles que l’harmonie et l’ordre.
ANÁLISIS BIBLIOMÉTRICO DE LITERATURA SOBRE EL CONCEPTO DE MARKETING DIGITAL PARA EL PERIODO 2015-2022
Authors: Gutiérrez Gutiérrez Ronald Ariel , González Díaz Carmen Angélica 
Published: July 2023

El marketing digital constituye una de las principales estrategias que están utilizando las empresas hoy en día para dar a conocer sus productos y servicios en internet. En el presente trabajo se muestra un análisis bibliométrico de este término para el periodo 2015-2022. Para llevar a cabo este proceso se accedió a la base de datos sciencedirect.com en la cual se analizó la producción científica de 8 años relacionada a este concepto. La palabra clave utilizada fue marketing digital, los criterios de búsqueda establecidos se delimitaron a título, resumen o palabras claves especificadas por el autor. Se obtuvieron como resultado 500 artículos de los cuales 41 son de revisión y 459 de investigación. Las áreas temáticas en las que se encuentran estas publicaciones son: negocios, administración y contabilidad, ciencias sociales, psicología, informática, ciencias de la decisión, medicina y odontología, ingeniería, ciencias agrarias y biológicas, artes y humanidades, economía, econometría y finanzas. Se construyó un mapa bibliométrico utilizando la herramienta vosviewer en la cual se aprecian 7 clúster agrupados en palabras clave. El clúster 1 y 2 muestran la agrupación más alta de palabra clave (9 ítems). El clúster 3 agrupó: 8 ítems, el clúster 4, 5 y 6: 5 ítems y el clúster 7: 4 ítems. La mayor cantidad de publicaciones aparece en el año 2021, por tal razón se concluye que ese año se buscaron estrategias de posicionamiento para las empresas en época de pandemia y el marketing digital fue una de ellas.
Session 11
Authors: Hope Iain , Wee Alison Kim Shan 
Published: July 2023

Environmental adaption of rubisco in global marine systemsMarine environments are responsible for 50% of the net primary fixation of carbon globally. Predominantly, the Calvin Benson Basham cycle fixes carbon with the initial enzyme being Rubisco. Rubisco has been shown to be a significant bottleneck in photosynthesis, due to a slow catalytic rate and promiscuity of the enzyme. Previous Rubisco studies have largely focused on land plants, and little is known about the diversity and abundance of Rubisco within marine environments. Through analysing publicly available metagenomes and metatranscriptomes from the Earth’s seas and oceans; we have begun to paint a picture of the global abundance and variation of Rubisco. On top of this, sequence analysis of Rubisco structures provides evidence for adaption of the large and small subunit to differing environments, highlighting residues that diverge in tropical and polar systems. This study expands our knowledge of the Rubisco sequence space and presents opportunities for future engineering projects in economically important plants.Southeast Asian Mangroves in a Changing World: Insights from Phylogeography, Gene Expression and eDNA MetabarcodingMangroves are one of the most threatened ecosystems in the world. Understanding the drivers and limitations of gene flow, phylogeography and genetic adaptation is crucial to effectively manage the threats and conserve the long-term evolutionary potential of mangroves. The first part of this talk summarizes key research findings on the biogeography of major mangrove tree species in Southeast Asia and the greater Indo-West Pacific region. In essence, propagule dispersal capabilities, land barriers and ocean currents are drivers of gene flow and underscores the importance of long-distance dispersal in connecting fragmented mangrove populations. The second part of the talk describes our work on abiotic stress response in mangroves, especially at the species range limits. Current understanding of the molecular mechanism underlying stress adaptation points toward diverging strategies in stress response, even among closely related species. These studies will be important in estimating the adaptive potential of mangroves under climate change. The third part of this talk focuses on recent pstudies on the application of environmental DNA (eDNA) as an effective biomonitoring tool in mangroves. Our findings demonstrated the dynamic distribution of fish species, the transient nature of eDNA in tropical waters, and the importance of bioregionalization in designing global studies.
Session 8 - Deciphering the SUMO code for adaptive responses in plants
Authors: Sadanandom Ari 
Published: July 2023

Post-translational modification (PTM) events generate proteoforms that orchestrate cell signalling in almost every biological process. The SUMOcode project aims to understand a critically important but understudied PTM in plants, SUMO (Small Ubiquitin-like Modifier). The rules governing specificity and function remain rudimentary for most PTMs, but the plant SUMO system provides a unique possibility to unravel the rules governing SUMOylation, as its core machinery comprises only 33 genes in Arabidopsis, compared with many hundreds for other PTMs.Our central hypothesis is that SUMO specificity is conferred through how cells are primed to respond to different stress signals, the tissue and cellular spatial distribution of SUMO machinery and substrates and control of SUMOylation modification via activation, repression and competition for PTM sites.We have developed a SUMO system cell atlas (a resource that will characterize each part of the machinery), how and in which cells and when it works, so that a map of the key events that trigger a SUMOylation response to environmental cues can be revealed.
Clinical and hardware evaluation of moisturizing properties and tolerability of a emollient cream with filagrinol (“Admera”) in atopic dermatitis in children
Authors: Masalskiy S. S. , Smolkin Yu. S. , Smolkina O. Yu. 
Published: July 2023

Objective. Evaluate the possibility of using a cream with 5 % filagrinol ("Admera") in children (0-18 years old) as an emollient in atopic dermatitis (AtD) and receive hardware measurements of skin hydration.Materials and methods. Open interventional study in parallel groups of children with AtD 0-18 years old (n = 72, median age 6 [3.75; 7.0] years). 2 equal groups: group 1 received methylprednisolone cream 1 time daily on lesions for 14 days + Admera emollient on the other skin; group 2 received the same treatment + cream with filagrinol 5 % applied from day 5 on the lesions.Results. Standard therapy with topical steroids and emollients was effective. The severity indices during steroid + emollient treatment decreased significantly: EASI 11.5 [6.0; 17.0] vs 2 [1; 3.8] scores, p < 0.001; skin lesion area from 17.5 % [10.0; 26.8 %] to 3.5 % [1.25; 6.0 %], p < 0.001; IGA score — 2 [2; 3] vs 1 [1; 2], p < 0.01.The total itching score for AtD (max 10) became significantly lower with therapy: nocturnal itching decreased from 3 [1; 7] to 1 [1; 3] and daytime itching from 4 [3; 7] to 2.5 [1; 4] points, p < 0.01.The mean values of hardware-measured skin hydration outside the lesion areas were 8 [6.0; 12.0] units at baseline. After 14 days of emollient, hydration of dry clear skin increased to 10 [8.0; 15.0] units (p = 0,017). The hydration of the skin on the affected areas increased significantly from 8 [6; 10] to 12.0 [8; 15] units (p = 0.001).The patients' organoleptic evaluation of the cream was 4.48 (max 5). No serious or moderate adverse events (AEs) were reported in this study. In 11.3 % of cases, the skin itching was detected, but resolved rapidly without treatment.Conclusion. The cream with 5 % filagrinol (“Admera”) significantly improved skin hydration, as measured instrumentally, in the area of dermatitis and dry skin without ones. The cream caused no significant adverse reactions and could be used together with topical steroids.