bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes After Preoperative Chemoradiation With or Without Pazopanib in Non-Rhabdomyosarcoma Soft Tissue Sarcoma: A Report From Children's Oncology Group and NRG Oncology
Authors: Weiss Aaron R. , Chen Yen-Lin , Scharschmidt Thomas J. , Xue Wei , Gao Zhengya , Black Jennifer O. , Choy Edwin , Davis Jessica L. , Fanburg-Smith Julie C. , Kao Simon C. , Kayton Mark L. , Kessel Sandy , Lim Ruth , Million Lynn , Okuno Scott H. , Ostrenga Andrew , Parisi Marguerite T. , Pryma Daniel A. , Randall R. Lor , Rosen Mark A. , Shulkin Barry L. , Terezakis Stephanie , Venkatramani Rajkumar , Zambrano Eduardo , Wang Dian , Hawkins Douglas S. , Spunt Sheri L. 
Published: July 2023

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. ARST1321 was a phase II study designed to compare the near complete pathologic response rate after preoperative chemoradiation with/without pazopanib in children and adults with intermediate-/high-risk chemotherapy-sensitive body wall/extremity non-Rhabdomyosarcoma Soft Tissue Sarcoma (ClinicalTrials.gov identifier: NCT02180867 ). Enrollment was stopped early following a predetermined interim analysis that found the rate of near complete pathologic response to be significantly greater with the addition of pazopanib. As a planned secondary aim of the study, the outcome data for this cohort were analyzed. Eight-five eligible patients were randomly assigned to receive (regimen A) or not receive (regimen B) pazopanib in combination with ifosfamide and doxorubicin + preoperative radiotherapy followed by primary resection at week 13 and then further chemotherapy at week 25. As of December 31, 2021, at a median survivor follow-up of 3.3 years (range, 0.1-5.8 years), the 3-year event-free survival for all patients in the intent-to-treat analysis was 52.5% (95% CI, 34.8 to 70.2) for regimen A and 50.6% (95% CI, 32 to 69.2) for regimen B ( P = .8677, log-rank test); the 3-year overall survival was 75.7% (95% CI, 59.7 to 91.7) for regimen A and 65.4% (95% CI, 48.1 to 82.7) for regimen B ( P = .1919, log-rank test). Although the rate of near complete pathologic response was significantly greater with the addition of pazopanib, outcomes were not statistically significantly different between the two regimens.
Non-perturbative stabilization of two Kähler moduli in type-IIB/F theory and the inflaton potential
Authors: Let Abhijit , Sarkar Arunoday , Sarkar Chitrak , Ghosh Buddhadeb 
Published: July 2023

Abstract
We consider a combination of perturbative and non-perturbative corrections in Kähler moduli stabilizations in the configuration of three magnetised intersecting D7 branes in the type-IIB/F theory, compactified on the 6d

orbifold of Calabi-Yau three-fold (CY3). Two of the Kähler moduli are stabilized non-perturbatively, out of the three which get perturbative corrections up to one-loop–order multi-graviton scattering amplitudes in the large volume scenario. In this framework, the dS vacua are achieved through all Kähler moduli stabilizations by considering the D-term. We obtain inflaton potentials of slow-roll plateau type, which are expected by recent cosmological observations. Calculations of cosmological parameters with the potentials yield experimentally favoured values.
Preferential killing of melanoma cells by a p16-related peptide
Authors: Soo Julia K. , Castle Joanna T. , Bennett Dorothy C. 
Published: July 2023

ABSTRACT
We report the identification of a synthetic, cell-penetrating peptide able to kill human melanoma cells efficiently and selectively, while being less toxic to normal human melanocytes and nontoxic to human fibroblasts. The peptide is based on the target-binding site of the melanoma suppressor and senescence effector p16 (also known as INK4A or CDKN2A), coupled to a cell-penetrating moiety. The killing is by apoptosis and appears to act by a route other than the canonical downstream target of p16 and CDK4, the retinoblastoma (RB) protein family, as it is also effective in HeLa cells and a melanocyte line expressing HPV E7 oncogenes, which both lack any active RB. There was varying toxicity to other types of cancer cell lines, such as glioblastoma. Melanoma cell killing by a p16-derived peptide was reported once before but only at a higher concentration, while selectivity and generality were not previously tested.
Induction of kidney-related gene programs through co-option of SALL1 in mole ovotestes
Authors: Schindler Magdalena , Osterwalder Marco , Harabula Izabela , Wittler Lars , Tzika Athanasia C. , Dechmann Dina K. N. , Vingron Martin , Visel Axel , Haas Stefan A. , Real Francisca M. 
Published: July 2023

ABSTRACT
Changes in gene expression represent an important source of phenotypic innovation. Yet how such changes emerge and impact the evolution of traits remains elusive. Here, we explore the molecular mechanisms associated with the development of masculinizing ovotestes in female moles. By performing integrative analyses of epigenetic and transcriptional data in mole and mouse, we identified the co-option of SALL1 expression in mole ovotestes formation. Chromosome conformation capture analyses highlight a striking conservation of the 3D organization at the SALL1 locus, but an evolutionary divergence of enhancer activity. Interspecies reporter assays support the capability of mole-specific enhancers to activate transcription in urogenital tissues. Through overexpression experiments in transgenic mice, we further demonstrate the capability of SALL1 to induce kidney-related gene programs, which are a signature of mole ovotestes. Our results highlight the co-option of gene expression, through changes in enhancer activity, as a plausible mechanism for the evolution of traits.
Neurogenesis redirects β-catenin from adherens junctions to the nucleus to promote axonal growth
Authors: Herrera Antonio , Menendez Anghara , Ochoa Andrea , Bardia Lídia , Colombelli Julien , Pons Sebastian 
Published: July 2023

ABSTRACT
Here, we show that, in the developing spinal cord, after the early Wnt-mediated Tcf transcription activation that confers dorsal identity to neural stem cells, neurogenesis redirects β-catenin from the adherens junctions to the nucleus to stimulate Tcf-dependent transcription in a Wnt-independent manner. This new β-catenin activity regulates genes implicated in several aspects of contralateral axon growth, including axon guidance and adhesion. Using live imaging of ex-vivo chick neural tube, we showed that the nuclear accumulation of β-catenin and the rise in Tcf-dependent transcription both initiate before the dismantling of the adherens junctions and remain during the axon elongation process. Notably, we demonstrated that β-catenin activity in post-mitotic cells depends on TCF7L2 and is central to spinal commissural axon growth. Together, our results reveal Wnt-independent Tcf/β-catenin regulation of genes that control the growth and guidance of commissural axons in chick spinal cord.
On the Formation of the Germinal Layers in Chelonia
Authors: Mitsukuri K. , lshikawa C. 
Published: July 2023

ABSTRACT
IN the spring of 1884 we made the acquaintance of Mr. Hattori, the proprietor of a large fish-hatching establishment in Honjō, a suburb of Tokyō. His father before him, and he, had succeeded in making the snapping turtle—Trionyx Japonicus, Schlegel—breed freely and naturally in captivity, and thus in furnishing the market with a constant and large supply of its delicate flesh. In his farm hundreds of these turtles are annually hatched, and if the eggs are marked as they are laid the exact age of any given deposit can be determined with great precision, even to minutes in many cases. Such an opportunity for the investigation of Reptilian development seemed to us too good to be thrown away, especially as nobody had, so far as we were aware at the time, worked on the embryology of Chelonia since the days of Agassiz and Clark, and therefore with modern methods of investigation. Mr. Hattori kindly consenting, we went to his farm daily during the breeding season of 1884 and of 1885, and succeeded in collecting a fairly complete series of the Tryonix embryos, beginning with the time when the eggs are deposited, and ending with their hatching out. The present paper gives the results of our study on the formation of the germinal layers. Papers on other points and later stages of development will follow from time to time since the investigation is being continued, as the pressure of other duties permit us,
Prevalence of carpal tunnel syndrome among dentists: a systematic review and meta-analysis
Authors: Kostares Evangelos , Kostare Georgia , Kostares Michael , Kantzanou Maria 
Published: July 2023

Purpose: To estimate the prevalence of carpal tunnel syndrome (CTS) among dental surgeons and the effect of possible moderators on it. Methods: A systematic literature search (Medline and Scopus databases) was conducted independently by two reviewers. Only observational studies that examined specifically the prevalence rates of CTS among dentists were included. Quality assessment was performed. The pooled prevalence with 95% confidence intervals (CI) was estimated. Outlier and influential analysis were conducted. Moderator analysis was performed in order the effect of categorical and continuous variables on the estimated prevalence to be investigated. Results: In total, ten eligible studies (3,547 participants) were finally included in this meta-analysis. Two of them were estimated as high quality (low risk of bias) and the remaining ones as moderate quality (moderate risk of bias). The overall prevalence of CTS among dental surgeons was estimated as 9.87% (95%CI 6.84%-14.03%) with significant heterogeneity between studies. No study was identified as influential. Potential sources of heterogeneity were not identified through meta-regression analysis. In the subgroup analysis the prevalence was 12.47% (95%CI 6.38%-22.95%) for the group identified as having CTS through medical history and at least clinical examination or electrodiagnostic testing and 8.56% (95%CI 5.53%-13.01%) among those who identified solely through questionnaire. Conclusions: Our findings are important to provide the pooled prevalence of CTS among dentists. Our results were based on highly heterogeneous studies. Our study reports a considerable prevalence, consequently, significance of awareness among dental surgeons regarding the etiology of this issue is more than necessary. More studies need to be conducted that could guide researchers in order this issue to be fully investigated.
The challenging reality of the clinical learning environment at Damascus University Faculty of Dental Medicine in Syria: a qualitative study
Authors: Alfakhry Ghaith , Mustafa Khattab , Jazayerli Bashar , Alhomsi Khaled , Jamous Issam 
Published: July 2023

Introduction: In Syria, specialist dentists undergo five years of undergraduate education and four years of postgraduate education. In the latter, students engage in treating complex cases as part of their professional training. This study aimed to obtain in-depth qualitative understanding of the clinical learning environment at Damascus University Faculty of Dental Medicine, Syria. Methods: Semi-structured interviews were held with eight postgraduate dental students at Damascus University Faculty of Dental Medicine. The faculty has eight clinical departments; therefore, a single participant was purposively sampled from each department. The male-female ratio of the eight interviewed participants was 1:1. All interviews were conducted between 26th April 2020 and 8th January 2021. Data was analyzed inductively using reflective thematic analysis. Pragmatic saturation was discussed during the analysis and the authors made an interpretative judgement to stop data collection at the eighth interview. Results: Major themes which emerged covered different aspects of the clinical learning environment such as clinical training, social interaction and assessment procedures. Faculty’s negligence of their teaching duties was one of the most recurrent themes. In clinical training and due to faculty inaccessibility, students had to rely on themselves or their senior peers in training. The social climate was perceived negatively and assessment was described as unfair and biased. Discussion: The findings of this study showcased the continuing deterioration of the clinical learning environment at Damascus University. It is hoped that these findings will encourage decision makers to introduce a comprehensive reform that addresses the curriculum, teaching practices and assessment procedures in clinical professional training.
COPO - Managing sample metadata for biodiversity: considerations from the Darwin Tree of Life project
Authors: Shaw Felix , Minotto Alice , McTaggart Seanna , Providence Aaliyah , Harrison Peter , Paupério Joana , Rajan Jeena , Burgin Josephine , Cochrane Guy , Kilias Estelle , Lawniczak Mara K.N. , Davey Robert 
Published: July 2023

Large-scale reference genome sequencing projects for all of biodiversity are underway and common standards have been in place for some years to enable the understanding and sharing of sequence data. However, the metadata that describes the collection, processing and management of samples, and link to the associated sequencing and genome data, are not yet adequately developed and standardised for these projects. At the time of writing, the Darwin Tree of Life (DToL) Project is over two years into its ten-year ambition to sequence all described eukaryotic species in Britain and Ireland. We have sought consensus from a wide range of scientists across taxonomic domains to determine the minimal set of metadata that we collectively deem as critically important to accompany each sequenced specimen. These metadata are made available throughout the subsequent laboratory processes, and once collected, need to be adequately managed to fulfil the requirements of good data management practice. Due to the size and scale of management required, software tools are needed. These tools need to implement rigorous development pathways and change management procedures to ensure that effective research data management of key project and sample metadata is maintained. Tracking of sample properties through the sequencing process is handled by Lab Information Management Systems (LIMS), so publication of the sequenced data is achieved via technical integration of LIMS and data management tools. Discussions with community members on how metadata standards need to be managed within large-scale programmes is a priority in the planning process. Here we report on the standards we developed with respect to a robust and reusable mechanism of metadata collection, in the hopes that other projects forthcoming or underway will adopt these practices for metadata.
Training Educators to Work in the Context of Inclusive Education
Authors: Vasil'eva O. 
Published: July 2023

Abstract. With the spread of inclusive education, new demands are placed on teachers, including their readiness to teach, educate, and assist in the development of children with special educational needs. Scientists recognize the need to make changes in the training of teachers in order to develop their readiness to teach children with disabilities.
The study presents an analysis of modern research on this issue using methods of analysis, systematization, and comparison of modern approaches to teacher training for inclusive education of children with disabilities. The study reveals scholars’ understanding of the term “readiness for inclusive education of children with disabilities” and a list of professional and personal qualities, value-semantic guidelines, and professional competencies that an inclusive education teacher should have. Scientific approaches to the training of such a specialist (competency-based, integrated) and proposed forms of education are critically analyzed, and issues of content and new technologies used in preparing a teacher for this type of professional are considered.
The study reveals the shortcomings of the current situation in the preparation for inclusive education of children with disabilities, the authors' views on changing the form of such training are offered. As a result of the analysis the prospects for further research in the field of teacher training for inclusive education of children with disabilities are highlighted.
A Multilateral Study of Social Intelligence and Associated Personal Characteristics of a Generation Z Student
Authors: Kyazimova K. , Krylova Natal'ya 
Published: July 2023

The study of the phenomenon of "social intelligence" in foreign and domestic psychology was discovered unexpectedly. In a generalized view, the concept under study is considered as a complex structural formation, including a set of abilities aimed at establishing interpersonal relationships; as a personal formation, regardless of general intelligence and associated with a specific activity. Recently, there has been an opinion about social intelligence as a clear and compatible group of mental abilities associated with the processing of social information, i.e. evaluating the level of adequacy and effectiveness of interaction. It should be noted that a special explanation is required of the relationship of intelligence as a cognitive ability linked to personality traits; intelligence and propensity to adapt to new expectations and events of the wedding, as well as the connection of intelligence, processes of self-regulation and control of the locus.
Separately, it is necessary to theoretically and applied comprehend the specific features of the student's generation when designing the conditions for the development of intelligence in the conditions of the educational process of higher education.
On Improving the Mechanism of Strategic Planning and Management of Vocational Education
Authors: Todosiychuk A. 
Published: July 2023

The article analyzes the current state of the regulatory framework and the corresponding mechanism of strategic planning and management of vocational education in the Russian Federation. The main element of the mechanism for implementing state policy in the field of personnel training is the state programs of scientific and technological development and education development. Poor quality and insufficiently balanced development of vocational education is one of the main factors of weak innovation activity of the economy. In turn, this creates a low demand for the training of new generations of personnel capable of ensuring the implementation of priority areas of scientific and technological development.
The article presents recommendations for improving the mechanism of strategic planning and management of vocational education, planning budget expenditures for science and vocational education.
Candida haemulonii complex, an emerging threat from tropical regions?
Authors: Françoise Ugo , Desnos-Ollivier Marie , Le Govic Yohann , Sitbon Karine , Valentino Ruddy , Peugny Sandrine , Chouaki Taieb , Mazars Edith , Paugam André , Nicolas Muriel , Desbois-Nogard Nicole , Lortholary Olivier ,   French Mycoses Study Group
Published: July 2023

Background
Candida haemulonii complex-related species are pathogenic yeasts closely related to Candida auris with intrinsic antifungal resistance, but few epidemiological data are available.

Methodology/Principal findings
We analyzed clinical and demographic characteristics of patients with fungemia due to C. haemulonii complex and related species (C. pseudohaemulonii, C. vulturna) reported in France during 2002–2021, and compared them to data of C. parapsilosis fungemia, as they all can be commensal of the skin. We also conducted a study on adult inpatients and outpatients colonized by C. haemulonii complex, managed at the University Hospital of Martinique during 2014–2020. Finally, we performed a literature review of fungemia due to C. haemulonii complex and related species reported in Medline (1962–2022).
In total, we identified 28 fungemia due to C. haemulonii complex in France. These episodes were frequently associated with bacterial infection (38%) and high mortality rate (44%), and differed from C. parapsilosis fungemia by their tropical origin, mainly from Caribbean and Latin America. All isolates showed decreased in vitro susceptibility to amphotericin B and fluconazole. In Martinique, we found that skin colonization was frequent in the community population, while colonization was strongly associated with the presence of foreign devices in ICU patients. The literature review identified 274 fungemia episodes, of which 56 were individually described. As in our national series, published cases originated mainly from tropical regions and exhibited high crude mortality.

Conclusions/Significance
Multidrug-resistant C. haemulonii complex-related species are responsible for fungemia and colonization in community and hospital settings, especially in tropical regions, warranting closer epidemiological surveillance to prevent a potential C. auris-like threat.
Can women’s reports in client exit interviews be used to measure and track progress of antenatal care services quality? Evidence from a facility assessment census in Malawi
Authors: Mchenga Martina , Burger Ronelle , von Fintel Dieter 
Published: July 2023

Introduction
Unlike household surveys, client exit interviews are conducted immediately after a consultation and therefore provides an opportunity to capture routine performance and level of service quality. This study examines the validity and reliability of women’s reports on selected ANC interventions in exit interviews conducted in Malawi.

Methods
Using data from the 2013–2014 Malawi service provision facility census, we compared women’s reports in exit interviews regarding the contents of ANC received with reports obtained through direct observation by a trained healthcare professional. The validity of six indicators was tested using two measures: the area under the receiver operating characteristic curve (AUC), and the inflation factor (IF). Reliability of women’s reports was measured using the Kappa coefficient (κ) and the prevalence-adjusted bias-adjusted kappa (PABAK). Finally, we examined whether reporting reliability varied significantly by individual and facility characteristics.

Results
Of the six indicators, two concrete and observable measures had high reporting accuracy and met the validity criteria for both AUC ≥ 0.7 and 0.75>IF>1.25, namely whether the provider prescribed or gave malaria prophylaxis (AUC: 0.84, 95% CI: 0.83–0.86; IF: 0.96) or iron/folic tablets (AUC: (0.84 95% CI: 0.81–0.87; IF:1.00). Whereas four measures related to counselling had lower reporting accuracy: whether the provider offered counselling about nutrition in pregnancy (AUC: 0.69, 95%CI: 0.67–0.71; IF = 1.26), delivery preparation (AUC: 0.62, 95% CI: 0.60–065; IF = 0.99), pregnancy related complications (AUC: 0.59, 95%CI: 0.56–0.61; IF = 1.11), and iron/folic acid side effects (AUC:0.58, 95% CI: 0.55–0.60; IF = 1.42). Similarly, the observable measures had high reliability with both κ and PABAK values in the ranges of ≥ 0.61 and ≥ 0.80. Respondent’s age, primiparous status, number of antenatal visits, and the type of health provider increased the likelihood of reporting reliability.

Conclusion
In order to enhance the measurement of quality of ANC services, our study emphasizes the importance of carefully considering the type of information women are asked to recall and the timing of the interviews. While household survey programmes such as the demographic health survey and multiple indicator cluster survey are commonly used as data sources for measuring intervention coverage and quality, policy makers should complement such data with more reliable sources like routine data from health information systems.