bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurofilament light chain levels indicate acute axonal damage under bortezomib treatment
Authors: Cebulla Nadine , Schirmer Daniel , Runau Eva , Flamm Leon , Gommersbach Sonja , Stengel Helena , Zhou Xiang , Einsele Hermann , Reinhold Ann-Kristin , Rogalla von Bieberstein Bruno , Zeller Daniel , Rittner Heike , Kortüm K. Martin , Sommer Claudia 
Published: February 2023

Abstract
Introduction
Bortezomib (BTZ) is a selective and reversible proteasome inhibitor and first line treatment for multiple myeloma (MM). One of the side effects is BTZ-induced peripheral neuropathy (BIPN). Until now there is no biomarker which can predict this side effect and its severity. Neurofilament light chain (NfL) is a neuron specific cytoskeletal protein, of which higher levels can be detected in peripheral blood in case of axon damage. In this study, we aimed to evaluate the relationship between NfL serum levels and characteristics of BIPN.

Methods
We performed a first interim analysis of a monocentric, non-randomized, observational clinical trial including 70 patients (DRKS00025422) diagnosed with MM in the inclusion period of June 2021 until March 2022. Two groups of patients—one with ongoing BTZ treatment at the time of recruiting, and one with BTZ treatment in the past—were compared to controls. NfL in serum was analyzed via the ELLA™ device.

Results
Both patients with previous and ongoing BTZ treatment had higher serum NfL levels than controls, and patients with ongoing BTZ treatment had higher NfL levels than patients with BTZ treatment in the past. Serum NfL levels correlated with electrophysiological measures of axonal damage in the group with ongoing BTZ treatment.

Conclusion
Elevated NfL levels indicate acute axonal damage under BTZ in MM patients.
Increased physical workload in home care service is associated with reduced recovery from work
Authors: Mänttäri Satu , Säynäjäkangas Pihla , Selander Kirsikka , Laitinen Jaana 
Published: February 2023

Abstract
Objective
This study investigated the physical workload of home care service workers and determined whether the different intensities of physical work strain experienced by home care nurses have different impacts on their recovery from work.

Methods
Physical workload and recovery were measured among 95 home care nurses based on heart rate (HR) and heart rate variability (HRV) recordings during one work shift and the following night. Differences in the physical work strain were compared between younger (≤ 44-year-old) and older (≥ 45-year-old) employees and between morning and evening shifts. To determine the effects of occupational physical activity on recovery, HRV at all time points (during the workday, when awake and asleep, and whole measurement) in relation to the amount of occupational physical activity was examined.

Results
The average physiological strain during the work shift, measured as metabolic equivalent (MET), was 1.8 ± 0.5. Moreover, the occupational physical demands in relation to maximal capacity were higher for the older employees. The results of the study showed that a higher occupational physical workload reduced the HRV of home care workers during the workday, leisure time, and sleep.

Conclusions
These data indicate that increased occupational physical workload is associated with reduced recovery among home care workers. Therefore, decreasing occupational strain and ensuring sufficient recovery is recommended.
Epidemiology and outcomes of traumatic chest injuries in children: a nationwide study in the Netherlands
Authors: Sweet Arthur A. R. , de Bruin Ivar G. J. , Peek Jesse , IJpma Frank F. A. , van Baal Mark C. P. M. , Leenen Luke P. H. , Houwert Roderick M. 
Published: February 2023

AbstractThoracic injuries are infrequent among children, but still represent one of the leading causes of pediatric mortality. Studies on pediatric chest trauma are dated, and little is known of outcomes in different age categories. This study aims to provide an overview of the incidence, injury patterns, and in-hospital outcomes of children with chest injuries. A nationwide retrospective cohort study was performed on children with chest injuries, using data from the Dutch Trauma Registry. All patients admitted to a Dutch hospital between January 2015 and December 2019, with an abbreviated injury scale score of the thorax between 2 and 6, or at least one rib fracture, were included. Incidence rates of chest injuries were calculated with demographic data from the Dutch Population Register. Injury patterns and in-hospital outcomes were assessed in children in four different age groups. A total of 66,751 children were admitted to a hospital in the Netherlands after a trauma between January 2015 and December 2019, of whom 733 (1.1%) sustained chest injuries accounting for an incidence rate of 4.9 per 100,000 person-years. The median age was 10.9 (interquartile range (IQR) 5.7–14.2) years and 62.6% were male. In a quarter of all children, the mechanisms were not further specified or unknown. Most prevalent injuries were lung contusions (40.5%) and rib fractures (27.6%). The median hospital length of stay was 3 (IQR 2–8) days, with 43.4% being admitted to the intensive care unit. The 30-day mortality rate was 6.8%.Conclusion: Pediatric chest trauma still results in substantial adverse outcomes, such as disability and mortality. Lung contusions may be inflicted without fracturing the ribs. This contrasting injury pattern compared to adults underlines the importance of evaluating children with chest injuries with additional caution.

What is Known:• Chest injuries are rare among children, but represent one of the leading causes of pediatric mortality.• Children show distinct injury patterns in which pulmonary contusions are more prevalent than rib fractures.

What is New:• The proportion of chest injuries among pediatric trauma patients is currently lower than reported in previous literature, but still leads to substantial adverse outcomes, such as disabilities and death.• The incidence of rib fractures gradually increases with age and in particular around puberty when ossification of the ribs becomes completed. The incidence of rib fractures among infants is remarkably high, which is strongly suggestive for nonaccidental trauma.
Competing risk nomogram for predicting prognosis of patients with spinal and pelvic chordoma: A SEER-based retrospective study
Authors: Li Junhong , Ma Cong , Yuan Xuhui , Li Na , Xu Yong , Guo Jianfeng , Liao Hui 
Published: February 2023

Abstract
Purpose
Recently, competing risk nomograms were widely applied to predict prognosis in numerous tumors other than chordoma. Here, we aimed to construct and validate a competing-risk-based prognostic nomogram to predict 3- and 5-year cancer-specific death (CSD) in patients with spinal and pelvic chordoma.

Methods
All chordoma patient data were abstracted from the Surveillance, Epidemiology, and End Results (SEER) resource, and a total of 485 chordoma patients were eventually included in this study. Multivariate competing risk model and multivariate Cox model were used to determine independent prognostic factors, respectively, and the results of the two models were compared. Nomogram was employed to visualize the competing risk model. The discrimination, calibration, and clinical utility of this model were evaluated by Harrell concordance index (C-index), time-dependent receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis (DCA). Ten-fold cross-validation was further utilized to validate the prognostic nomogram.

Results
Significant prognostic factors affecting CSD were age (P = 0.016), localized involvement (P < 0.0001), and radical resection (P < 0.001) in the multivariate competing risk model. C-indexes were 0.799 and 0.76, and AUC were 0.812 and 0.778 for 3- and 5-year CSD. Calibration plots demonstrated the nomogram was well-fitted, and DCA indicated good clinical utility. The nomogram showed good performance in the 10-fold cross-validation.

Conclusion
We successfully built the first competing-risk-based nomogram to predict clinical outcomes in patients with spinal and pelvic chordoma. This well-established nomogram hopes to help clinicians with precise prognostic assessment and thus improve clinical outcomes.
Modified lanthanide-doped carbon dots as a novel nanochemosensor for efficient detection of water in toluene and its potential application in lubricant base oils
Authors: Chimeno-Trinchet Christian , Pacheco Maria Emilia , Fernández-González Alfonso , Badía-Laíño Rosana 
Published: February 2023

Abstract
A fast and efficient method was developed for obtaining europium(III)-doped surface-modified carbon dots with a hydrophobic coating. This surface functionalization improved the dispersibility of the nanoparticles in non-polar media, as well as modified the accessibility of water molecules to the europium ions. These two features allowed studying the application of doped carbon dots as moisture nanochemosensor, demonstrating high stability over time of both the photoluminescent signal intensity and the stability of the dispersions. The developed nanochemosensor was used to determine water in toluene with a detection limit of 8.5 × 10−4 M and a quantification limit of 2.4 × 10−3 M. The proposed system matches and even improves other methodologies for water determination in organic solvents; it has a low detection limit and a fast response time (almost instantaneous) and requires neither expensive material nor trained personnel. The results suggest a promising future for the development of a new sensing phase for moisture determination in lubricant base oil.
Graphical Abstract
Microbead-based extracorporeal immuno-affinity virus capture: a feasibility study to address the SARS-CoV-2 pandemic
Authors: Jarvas Gabor , Szerenyi Dora , Jankovics Hajnalka , Vonderviszt Ferenc , Tovari Jozsef , Takacs Laszlo , Foldes Fanni , Somogyi Balazs , Jakab Ferenc , Guttman Andras 
Published: February 2023

AbstractIn this paper, we report on the utilization of micro-technology based tools to fight viral infections. Inspired by various hemoperfusion and immune-affinity capture systems, a blood virus depletion device has been developed that offers highly efficient capture and removal of the targeted virus from the circulation, thus decreasing virus load. Single-domain antibodies against the Wuhan (VHH-72) virus strain produced by recombinant DNA technology were immobilized on the surface of glass micro-beads, which were then utilized as stationary phase. For feasibility testing, the virus suspension was flown through the prototype immune-affinity device that captured the viruses and the filtered media left the column. The feasibility test of the proposed technology was performed in a Biosafety Level 4 classified laboratory using the Wuhan SARS-CoV-2 strain. The laboratory scale device actually captured 120,000 virus particles from the culture media circulation proving the feasibility of the suggested technology. This performance has an estimated capture ability of 15 million virus particles by using the therapeutic size column design, representing three times over-engineering with the assumption of 5 million genomic virus copies in an average viremic patient. Our results suggested that this new therapeutic virus capture device could significantly lower virus load thus preventing the development of more severe COVID-19 cases and consequently reducing mortality rate.
Graphical Abstract
Neurobiological correlates and attenuated positive social intention attribution during laughter perception associated with degree of autistic traits
Authors: Martinelli Anne , Hoffmann Elgin , Brück Carolin , Kreifelts Benjamin , Ethofer Thomas , Wildgruber Dirk 
Published: February 2023

AbstractLaughter plays an important role in group formation, signaling social belongingness by indicating a positive or negative social intention towards the receiver. In adults without autism, the intention of laughter can be correctly differentiated without further contextual information. In autism spectrum disorder (ASD), however, differences in the perception and interpretation of social cues represent a key characteristic of the disorder. Studies suggest that these differences are associated with hypoactivation and altered connectivity among key nodes of the social perception network. How laughter, as a multimodal nonverbal social cue, is perceived and processed neurobiologically in association with autistic traits has not been assessed previously. We investigated differences in social intention attribution, neurobiological activation, and connectivity during audiovisual laughter perception in association with the degree of autistic traits in adults [N = 31, Mage (SD) = 30.7 (10.0) years, nfemale = 14]. An attenuated tendency to attribute positive social intention to laughter was found with increasing autistic traits. Neurobiologically, autistic trait scores were associated with decreased activation in the right inferior frontal cortex during laughter perception and with attenuated connectivity between the bilateral fusiform face area with bilateral inferior and lateral frontal, superior temporal, mid-cingulate and inferior parietal cortices. Results support hypoactivity and hypoconnectivity during social cue processing with increasing ASD symptoms between socioemotional face processing nodes and higher-order multimodal processing regions related to emotion identification and attribution of social intention. Furthermore, results reflect the importance of specifically including signals of positive social intention in future studies in ASD.
Differential analysis of culturable and unculturable subgingival target microorganisms according to the stages of periodontitis
Authors: Lafaurie Gloria Inés , Castillo Diana Marcela , Iniesta Margarita , Sanz Mariano , Gómez Luz Amparo , Castillo Yormaris , Pianeta Roquelina , Delgadillo Nathaly Andrea , Neuta Yineth , Diaz-Báez David , Herrera David 
Published: February 2023

Abstract
Objectives
Culturable and unculturable microorganisms have been associated with periodontitis. Their differential proportions and composition have not been evaluated by their severity and complexity defined by stages in the 2018 AAP-EEP classification.

Methods
One hundred eighty subgingival biofilm samples were collected in Spain and Colombia from subjects categorized as health/gingivitis: periodontitis stages I/II periodontitis stages III/IV. Target culturable microorganisms (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, Treponema denticola, and Eubacterium nodatum) and target unculturable microorganisms (Filifactor alocis, Eubacterium saphenum, Eubacterium brachy, Desulfobulbus oralis) were evaluated by quantitative PCR analysis. In addition, their differences and association with periodontal status were analyzed by ANCOVA and logistic regression models once adjusted to age, current smoking, and country.

Results
P. gingivalis was significantly associated with periodontitis stages I/II, OR 2.44 (CI 95% 1.08–5.47) and stages III/V, OR 6.43 (CI 95% 2.43–16.9). T forsythia, OR 7.53 (CI 95% 2.07–27.4); D. oralis, OR 5.99 (CI 95% 2.71–13.23); F. alocis, OR 10.9 (CI 95% 4.56–23.2); E. brachy, 3.57 (CI 95% 1.40–9.11); and E. saphenum, 4.85 (CI 95% 1.99–11.7) were significantly associated only with stages III/IV periodontitis. P. gingivalis evidenced significant differences with the increase in the severity of the periodontal lesion: 2.97 colony forming unit (CFU)/μL (CI 95% 2.32–3.54) health/gingivitis, and 4.66 CFU/μL (CI 95% 4.03–5.30) and 5.90 CFU/μL (CI 95% 5.20–6.48) in stages I/II and III/IV respectively (p < 0.0001). Unculturable microorganisms only evidenced differences in concentration in stages III/IV compared with health-gingivitis (p ≤ 0.001).

Conclusion
Culturable and unculturable are strongly associated with stages III/IV periodontitis. Classic culturable microorganisms are more sensitive to differentiate between stages of periodontitis in the quantitative analysis.

Clinical relevance
Future interventional studies of periodontal disease should include Filifactor alocis, Eubacterium saphenum, Eubacterium brachy, and Desulfobulbus oralis as possible markers of therapy response and as indicators of progressive disease.
Sociodemographic, psychological, and clinical characteristics associated with health service (non-)use for mental disorders in adolescents and young adults from the general population
Authors: Reich H. , Niermann H. C. M. , Voss C. , Venz J. , Pieper L. , Beesdo-Baum K. 
Published: February 2023

AbstractMost adolescents and young adults who experience psychological distress do not seek professional help. This study aims to enhance the understanding of sociodemographic, psychological, and clinical characteristics associated with the underuse of health services by adolescents and young adults with mental disorders. Data from a cross-sectional, epidemiological study with a population-based sample (N = 1180 participants, 14–21 years old) were used. Participants completed a fully standardized, computer-assisted diagnostic interview (DIA-X-5/D-CIDI) administered by trained clinical interviewers to assess lifetime mental disorders according to DSM-5 as well as lifetime health service use for mental health problems, and completed self-report questionnaires to assess various psychological variables (e.g., stigma). Predictors of health service use were examined using univariate and multiple logistic regression analyses, data were weighted for age and sex to improve representativeness Of n = 597 participants with any lifetime mental disorder, 32.4% [95% CI 28.4; 36.7] had ever used any health services because of a mental health, psychosomatic, or substance use problem. Even less had received psychotherapeutic or pharmacological treatment (Cognitive Behavioral Therapy: 12.1% [9.5; 15.2]; other psychotherapy: 10.7% [8.4; 13.7]; medication: 5.4% [3.7; 7.8]). High education was associated with less health service use (low/ middle/ other vs. high education: 53.8% vs. 26.9%; OR = 0.26, p < .001). In the multiple regression model, stigma toward mental disorders was the single psychological variable associated with a reduced likelihood of using health services (OR = 0.69 [0.52; 0.90], p < .01). These findings draw attention to the treatment gap for mental disorders during adolescence and highlight related factors to be addressed in public health contexts.
Effect of display of YOLO’s object recognition results to HMD for an operator controlling a mobile robot
Authors: Sasaki Yuichi , Kamegawa Tetsushi , Gofuku Akio 
Published: February 2023

AbstractAn operator feels a burden when he/she controls a rescue robot remotely because he/she has to keep watching camera images to find the target object. We think that this burden can be reduced by the combination of Head Mounted Display (HMD) and object recognition by deep learning. In the first half part of this study, we examine the effect that how presentation method by You Only Look Once (YOLO), a deep learning algorithm, and its recognition results to an operator wearing HMD. In the experiment, three methods of presentation were set: no display of object recognition, display only one object recognition result, and display 80 kinds of object recognition results. Under each presentation method, we measured the time it took for the operator to operate the robot and complete the given task. Additionally, we ask a questionnaire for each experiment. The results of the questionnaire showed that the method to present only one object recognition result was useful. In the second half part of this study, we develop a system to present 3D images with YOLO added, to further ease the burden of object search. Furthermore, we numerically prove that this system represents depth. In the experiment, two methods of displaying were set up: 2D images with Bounding Box (BB) by YOLO and 3D images with BB by YOLO. For each method of presentation, the operator operated the robot and recorded the number of objects found within a time limit. Additionally, we asked a questionnaire at the end of the search in each condition and at the end of all the experiments. The results of the questionnaire suggested points that need to be improved. Furthermore, we consider the flicker of the image found in the experiment.
The Hungarian insurance market structure: an empirical analysis
Authors: Varga Veronika , Madari Zoltán 
Published: February 2023

AbstractThis paper analyzes the market structure of the Hungarian insurance market, which operated as a monopoly market until 1986. After the regime change this sector started to develop rapidly. But the Hungarian insurance market has a strong oligopolistic character, and thus raises an interesting question as to how close the market is to a state of perfect competition. Based on the Panzar and Rosse (J Ind Econ 35:443–456, 1987) methodology we estimate the elasticity of total revenues with respect to changes in input prices, so that we can determine the market structure. The estimation of input price elasticity is made with a static and a dynamic panel model. According to research the structure of the Hungarian insurance market significantly differs from the perfect competition case between 2010 and 2019. The market is in long-run equilibrium, and the hypothesis of the monopoly case cannot be rejected. The market structure of a sector is important for modelling phenomena and new regulations effectively, which is relevant for insurance and competition supervision in the protection of customers.
Efficacy and safety of super pulse CO2 laser-assisted punctoplasty with canalicular curettage in primary canaliculitis
Authors: Huang Weifeng , Cao Shujuan , Xie Lingling , Li Xingyi , Meng Ziwei , Yu Xinyue , Huang Danping , Chen Rongxin , Liang Xuanwei 
Published: February 2023

AbstractThe objective of this study was to evaluate the efficacy and safety of super pulse CO2 laser-assisted punctoplasty with canalicular curettage in primary canaliculitis. In this retrospective serial case study, the clinical data of 26 patients who underwent super pulse CO2 laser-assisted punctoplasty for the treatment of canaliculitis were collected from January 2020 to May 2022. The clinical presentation, intraoperative and microbiologic findings, surgical pain severity, postoperative outcome, and complications were studied. Of the 26 patients, most were females (female:male 20:6), with a mean age of 60.1 ± 16.1 years (range, 19–93). Mucopurulent discharge (96.2%), eyelid redness and swelling (53.8%), and epiphora (38.5%) were the most common presentations. During the surgery, concretions were present in 73.1% (19/26) of the patients. The surgical pain severity scores ranged from 1 to 5, according to the visual analog scale, with a mean score of 3.2 ± 0.8. This procedure resulted in complete resolution in 22 (84.6%) patients and significant improvement in 2 (7.7%) patients, and 2 (7.7%) patients required additional lacrimal surgery with a mean follow-up time of 10.9 ± 3.7 months. The surgical procedure of super pulse CO2 laser-assisted punctoplasty followed by curettage appears to be a safe, effective, minimally invasive, and well-tolerated treatment for primary canaliculitis.