bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racial and ethnic disparities in diagnosis, management and outcomes of aortic stenosis in the Medicare population
Authors: Ahmed Yunus , van Bakel Pieter A. J. , Hou Hechuan , Sukul Devraj , Likosky Donald S. , van Herwaarden Joost A. , Watkins Daphne C. , Ailawadi Gorav , Patel Himanshu J. , Thompson Michael P. ,   for the Structural Heart and Aortic Diseases Outcomes Research Workgroup Investigators
Published: April 2023

Importance
Aortic stenosis (AS) is one of the most common heart valve conditions and its incidence and prevalence increases with age. With the introduction of transcatheter aortic valve replacement (TAVR), racial and ethnic disparities in AS diagnosis, treatment and outcomes is poorly understood.

Objective
In this study we assessed racial and ethnic disparities in AS diagnosis, treatment, and outcomes among Medicare beneficiaries.

Design
We conducted a population-based cohort study of inpatient, outpatient, and professional claims from a 20% sample of Medicare beneficiaries

Main outcomes and measures
Incidence and Prevalence was determined among Medicare Beneficiaries. Outcomes in this study included management; the number of (non)-interventional cardiology and cardiothoracic surgery evaluation and management (E&M) visits, and number of transthoracic echocardiograms (TTE) performed. Treatment, which was defined as Surgical Aortic Valve Replacement and Transthoracic Aortic Valve Replacement. And outcomes described as All-cause Hospitalizations, Heart Failure Hospitalization and 1-year mortality.

Results
A total of 1,513,455 Medicare beneficiaries were diagnosed with AS (91.3% White, 4.5% Black, 1.1% Hispanic, 3.1% Asian and North American Native) between 2010 and 2018. Annual prevalence of AS diagnosis was lower for racial and ethnic minorities compared with White patients, with adjusted rate ratios of 0.66 (95% CI 0.65 to 0.68) for Black patients, 0.67 (95% CI 0.64 to 0.70) for Hispanic patients and 0.75 (95% CI 0.73 to 0.77) for Asian and North American Native patients as recent as 2018. After adjusting for age, sex and comorbidities, cardiothoracic surgery E&M visits and treatment rates were significantly lower for Black, Hispanic and Asian and North American Native patients compared with White patients. All-cause hospitalization rate was higher for Black and Hispanic patients compared with White patient. 1-year mortality was higher for Black patients, while Hispanic and Asian and North American Native patients had lower 1-year mortality compared with White patients.

Conclusions and relevance
We demonstrated significant racial and ethnic disparities in the diagnosis, management and outcomes of AS. The factors driving the persistence of these disparities in AS care need to be elucidated to develop an equitable health care system.
Diagnostic accuracy of CT angiography and CT perfusion imaging for detecting distal medium vessel occlusions: Protocol for a systematic review and meta-analysis
Authors: Sousa João André , Sondermann Anton , Bernardo-Castro Sara , Varela Ricardo , Donato Helena , Sargento-Freitas João 
Published: April 2023

Background
Distal medium vessel occlusions (DMVOs) represent 25–40% of all acute ischemic strokes (AIS). DMVO clinical syndromes are heterogenous, but as eloquent brain regions are frequently involved, they are often disabling. Since current intravenous fibrinolytic therapies may fail to recanalize up to two-thirds of DMVOs, endovascular treatment is progressively being considered in this setting. Nevertheless, the optimal imaging method for diagnosis remains to be defined. Stroke centers that use computed tomography as a routine stroke imaging approach rely on either isolated computed tomography angiography (CTA) or combined perfusion (CTP) studies. Despite a simplified non-CTP-dependent approach seeming reasonable for large vessel occlusion AIS diagnosis, CTP may still hold advantages for DMVOs workup. Therefore, this systematic review aims to compare the diagnostic performance of CTA and CTP in detecting DMVOs.

Methods
We will perform a systematic search in PubMed, EMBASE, Web of Science Core Collection, and Cochrane Central Register of Controlled Trials. In addition, grey literature and ClinicalTrials.gov will be scanned. We will include any type of study that presents data on the diagnostic accuracy of CTA and/or CTP for detecting DMVOs. Two authors will independently review retrieved studies, and any discrepancies will be resolved by consensus or with a third reviewer. Reviewers will extract the data and assess the risk of bias in the selected studies. Data will be combined in a quantitative meta-analysis following the guidelines provided by the Cochrane Handbook for Systematic Reviews of Interventions. We will assess cumulative evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach.

Discussion
This will be the first systematic review and meta-analysis that compares two different imaging approaches for detecting DMVOs. This study may help to define optimal acute ischemic stroke imaging work-up.

Trial registration
PROSPERO registration: CRD42022344006.
COVID-19 guidelines and its perceived effect on seafarers’ health and wellbeing: A qualitative study
Authors: Timilsina Amit , Baygi Fereshteh 
Published: April 2023

Background
The COVID-19 pandemic and its guidelines have had a profound impact on the social life, health, and wellbeing of people around the world. Very little is known if the guidelines are put into action effectively by seafarers. Also, the effects of such guidelines on seafarers’ health and wellbeing have not been studied so far. Therefore, this study aimed to explore the perceived effects of the COVID-19 guidelines on seafarers’ health and wellbeing.

Materials & methods
A qualitative research method was adopted using in-depth interviews. A total of 13 international male seafarers were interviewed until data saturation was achieved. Purposive sampling was used to recruit the respondents. The data was inductively coded using NVivo 12 and manifest content analysis was conducted.

Results
Once seafarers had access to COVID-19 guidelines, seafarers followed the guideline as suggested by companies under the guidance of captain. The majority of the participants reported that available guidelines could decrease their stress and anxiety levels, while some reported that implementing the COVID-19 guidelines had no significant effect on their health and wellbeing. The results of this study also showed a delay in repatriation, which had an impact on the seafarers’ mental health.

Conclusion
The guidelines could not address seafarers’ psychological needs to ensure their good health and wellbeing. Therefore, it is recommended that shipping companies address the mental health needs of seafarers during the COVID-19 pandemic and similar infectious diseases emerging in the future.
Diagnostic Obscurity of Gastrointestinal Subepithelial Tumors: An Organizing Gastric Hematoma Requiring En Bloc Resection
Authors: Miranda Clive Jude , Schertzing William , Shah Anushi , Del Prado Paul Anthony Reyes 
Published: April 2023

ABSTRACT
Gastric subepithelial tumors (SETs) are often incidentally found during examinations of the gastrointestinal tract. Able to arise from any layer of the stomach, these tumors are predominantly asymptomatic and are classified as either benign or malignant based on size, consistency, shape, and mobility as determined by endoscopic evaluation. We present the first reported case of a gastric SET presenting as a chronic organizing hematoma. In doing so, we discuss the necessity of multimodal imaging techniques and multidisciplinary management in identifying often obscure gastric SETs to intervene on potentially malignant masses early.
Sex reversal dynamics of Nile Tilapia (Oreochromis niloticus) and impact on growth performance
Authors: Nduku Grace , Mirera David O. , Nyabeta Jared 
Published: April 2023

AbstractNile Tilapia (Oreochromis niloticus) is one of the most economically important freshwater aquaculture species globally. However, reproduction during grow-out is a major problem that hinders fish growth. Therefore, production of all-male populations of tilapia has been developed to address the problem and is also identified as one of the most effective techniques of increasing tilapia growth. Various methods have been used to produce all males in Nile Tilapia i.e. use of hormone treatment (17- α-methyltestosterone), use of temperature shock and the recent YY technology. The latter two methods have limited documentation and usage in Kenya. The current study compared effectiveness of temperature and hormone sex reversed O. niloticus fry and influence on growth in hapa nets over a period of 3 months. Nile Tilapia fry of 3 days old after egg yolk absorption were sex reversed using hormone for 21 days and temperature shock for a period of 14 days. Hormone use involved making a dose of 60 mg kg-1 of feed while temperature shock involved raising temperature from 28°C to between 30 °C and 34 °C. Analysis of Specific Growth Rate using one-way analysis of variance, ANOVA, showed no significant difference between hormone and temperature induced sex reversed fish (F = 0.0975, P = 0.7705). Sex reversal efficacy rates of 91.18% and 92.86% were attained using 17- α-methyltestosterone hormone and temperature shock, respectively. The results indicate that temperature shock could be a replacement for Tilapia sex reversal without any negative consequences on growth.
ETIKA SOSIAL GUS DUR
Authors: Salam Abdus 
Published: April 2023

Islam as a complete religion that actually provides a view and the right way oflife. Yet in the reality Muslim often ignores to see social problems that continue to occur. This is seen from the lack of attention in Islam on the problem of poverty and oppression. Islam only appears in the form of individual mistake that escapist. Whereas, the Qur'an has clearly explained the concern very beautiful, as in QS. al-Baqarah [2]: 177. Therefore, it is important to re-read the meaning oflslam by more open and critical approach, one of them through discourse ethics, which in Islam is known as "akhlak" terms. Through the theological-philosophical approach, by tracing the motives of social ethicsin the thought of Abdurrahman Wahid, who understand (through indigenization of lslam) Islamic teaching (tauhid) critically in order to realize "social pillar", this research aims to probe again the akhlak relevance (Islam) in the context of humanitarianism and Indonesian culture to answer any real-life problem for the realization of social welfare.
KRITISISME KANT: RELEVANSINYA BAGI TEOLOGI ISLAM DAN KEMISKINAN
Authors: Widiadharma Novian , Arif Muhammad 
Published: April 2023

Poverty is the real phenomena within Indonesian Muslim communities. In order to be actual, Islamic Theology should give the answer to this real problem within ummah i.e. the problem of poverty. The question is could the theology to answer the problem of poverty? This research tries to reflect to Criticism developed by Immanuel Kant. By its criticism Kant successfully answer the question whether the metaphysics as a science is possible? However finally Kant tends to reject the validity of the metaphysics as a science, he still accepts the principle of synthesis a priori as a mode of science. In order to make Islamic Theology discourses could answer the problem of poverty, the Islamic Theology should learn from Kant criticism project. The Islamic Theology should move from a priory approach to synthetic a priory approach. Because without the support of historical-empirical approach in the social sciences, the a priori-ahistoris character of lslamic Theology toward social facts will never able to answer the problem ofpoverty within Indonesian Muslim communities.
METAFISIKA KETUHANAN DALAM PANDANGAN KALAM DAN PENGALAMAN RELIGIUS
Authors: Zulkarnain Iskandar 
Published: April 2023

Kalam, in general, could be stated as a study that focused to examine the central theological doctrines. By studying Kalam, it will give someone convictions based on solid arguments, not easily distracting by the change of time. Theological metaphysics is one of subject matter in Kalam. Metaphysics in Kalam supposed a certain level of understanding towards "God"; that assumed "God" could be understood. The equivocal term such as "being" (wujud) will obscure the understanding to that "being" should be translated to "existence" (mawjud), as consequence therefore "God" become "the permanent" (al-tsabit). Inrelation to Kalam, religious experience has a function as a spiritualvision benefactor in Kalam understanding. Profound appreciationthrough heart (dzauq and wijdan) to study of tauhid or Kalam make this study more appreciate and applicate in attitude. For that reason, religious experience is the perfection of study of tauhid from the perspective of religious experience; it is spiritual application from study oftauhid. This writing analyse the theological metaphysics by religious experience that is lack of attention according to the writer.
Transendensi Filsafat Ilmu ()
Authors: Saifullah Muhammad 
Published: April 2023

Judul buku : Filsafat Ilmu, Integrasi dan TransendensiPenulis : Musa Asy’ariePenerbit : LESFI UIN Sunan KalijagaTahun terbit : 2016Halaman : 143Pengulas : Muhammad Saifullah
Testing the stability of internal quality controls stored in the automated Atellica Solution refrigerated storage module
Authors: Rayo Hidalga Patricia , Domingo Bautista Carlos , Fernandez Bonifacio Rosa , Bedini Chesa Jose L. , Santana Naira Rico 
Published: April 2023

Abstract

Objectives
Atellica Solution (AS) is a platform that incorporates immunoassay and chemistry modules. AS is fitted with a refrigerated storage module (RSM) for internal quality controls (QC). The objective of this study was to assess the maximum permissible storage time in AS for QCs.

Methods
A total of 48 analytes were tested using QC materials: Liquid Assayed Multiqual (MQ), Liquichek Immunology (LI), Liquichek Lipids (LL), and Liquichek Urine Chemistry (UC). The percentage of variation between results (Xt%) was calculated as the difference between the mean value of the triplicate performed at every time point of the study (Xt) and the average of the triplicate performed in the baseline time (Xo). Stability was assessed based on the total change limit (TCL), which combines analytical and biological variation: TCL=±√((1.65 * CVa)2 + (0.5 * CVb)2).

Results
A total of 40 of the 48 analytes tested remained stable at the end of the study. In relation to MQ and UC QCs, 32 of the 39 analytes remained stable for the whole study period (15 days) except for alkaline phosphatase, aspartate aminotransferase, calcium, lactate dehydrogenase, and total bilirubin in MQ, and chlorine and glucose in UC. In LI and LL QCs, eight of the nine analytes were stable throughout the 20 days of the study, except transferrin in LI.

Conclusions
The Atellica Solution refrigerated storage module is a reliable system for the storage of quality control materials.
Influence of WO3 content on gamma rays attenuation characteristics of phosphate glasses at low energy range
Authors: Almuqrin Aljawhara H. , Abualsayed Mohammad Ibrahim 
Published: April 2023

Abstract
The radiation attenuation characteristics of WO3-Li2O-ZnO-P2O5 glasses have been examined using Phy-X software. The linear attenuation coefficient is correspondingly increased with the inclusion of WO3, which indicates the existence of a reducing tendency in the photon transmission correlating with an increment in the WO3 content in the glasses. When density is increased, there is a considerable reduction in the half-value layer (HVL), which is most noticeable between 80 and 100 keV. Because the HVL reaches high values at 100 keV for the samples, it can be deduced that the HVL steadily increases as the energy increases. Additionally, increasing the amount of WO3 in the glasses causes the mean free path (MFP) to decrease. The MFP for the glasses was compared with that of different heavy concretes, and the comparison demonstrated that the chosen systems have the potential to be used for the fabrication of protection masks that are utilized during diagnostic radiation treatment. We determined the ratio between the tenth value layer for the free-WO3 sample and the sample with 10 mol% and we found that the ratio is higher than 1, which suggests that the tenth value layer is decreased with the addition of WO3 to the glasses.
The Meaning of Human Life in the Context of the Evolution of the Universe: V. I. Vernadsky and P. Teilhard De Chardin
Authors: Plašienková Zlatica , Vertanová Silvia 
Published: April 2023

Abstract
The authors of the paper reflect on the meaning of human life in relation to the universe, drawing on scientific knowledge about evolution and highlighting interconnections between anthropological and cosmological issues. The paper considers the inspiring ideas of V. I. Vernadsky and P. Teilhard de Chardin, especially their understanding of the noosphere. Despite Vernadsky’s and Teilhard’s contrasting interpretations of the noosphere, the authors conclude that both consider the meaning of human life to be about self-improvement and taking responsibility for future evolution.
Developing a Digital History Project for Newport, Rhode Island: A Case Study of a Multimedia Tour and Place-Based Audio Storytelling
Authors: Knoth Brian 
Published: April 2023

Abstract
This case study explores the author’s use of techniques and processes associated with the digital humanities to research, create, and present a digital history project in Newport, Rhode Island. This is done by detailing and critically reflecting on the process of developing a multimedia tour and podcast episode based on the author’s original published research that investigated the role of music and social dancing during Newport’s emergence as a world-class resort in the Nineteenth Century. The multimedia tour featured in this case study makes use of digital location-based web and mobile application technologies to deliver a text and image-driven narrative with sonic enhancements augmenting the history. The podcast episode features place-based audio storytelling techniques which also enrich the understanding and potential reach of the subject. The multimedia tour and podcast episode in conjunction with the author’s original published research all work collectively to preserve Newport’s summer culture history. Some lessons learned include recognizing the advantages of utilizing established platforms, collaborating with experts, and embracing system constraints to optimize narrative focus.
Physicochemical investigations on the interaction of an anionic surfactant with cellulose based polymer microgel
Authors: Khan Abbas , Khan Sumayya , Khan Nazish , Naz Sumayya , Bououdina Mohamed , Rehman Noor , Humayun Muhammad , Shah Nasrullah , Anwar Natasha , Ali Hazrat 
Published: April 2023

Abstract
This work focuses on the interaction of cellulose-based colloidal microgel dispersions with the anionic surfactant sodium dodecyl sulfate (SDS) at different concentrations. First, a Cellulose-P(NIPAAm-MAA)-based responsive microgel sample was prepared by a radical polymerization method using a one-pot process. The samples thus obtained were purified, characterized and used to study microgel-surfactant interactions. To this end, SDS solutions with different concentrations were prepared and the interactions of SDS in the premicellar and micelle regions with polymer microgel were investigated using different physicochemical techniques. Experiments were also performed at different temperatures to obtain the degree of binding of SDS to microgel in gel surfactant mixtures. Due to the temperature-sensitive properties of microgel, we observed significant changes in various properties of microgel-surfactant mixtures when the solution temperature changed. The overall results showed that various experimental variables, such as the polymer gel/surfactant ratio and temperature, affect the gel–surfactant interaction quantitatively and qualitatively. With increasing surfactant concentration, conductance, viscosity and absorbance values ​​increased, but a decrease in surface tension was observed. This is due to the adsorption of SDS at the air-water interface. The micellar activity of surfactants is enhanced by the addition of microgels. It was found that the strength and nature of the interaction depended not only on the gel/surfactant ratio, solvent type and test temperature, but also on the chemical structure of the surfactant used. Furthermore, the visual stability of the colloidal particles in the mixture of microgel and SDS was also noticeable over time.
Functional segregation of the human cerebellum in social cognitive tasks revealed by TMS
Authors: Ferrari Chiara , Ciricugno Andrea , Arioli Maria , Cattaneo Zaira 
Published: April 2023

The role of the posterior cerebellum in social cognition is well established; however, it is still unclear whether different cerebellar subregions contribute to different social cognitive processes by exerting specific functions. Here we employed transcranial magnetic stimulation (TMS) in male and female healthy humans to test the hypothesis of the existence of a medial-to-lateral gradient in the functional organization of the posterior cerebellum, according to which the phylogenetically newer cerebellar hemispheres are involved in tasks requiring higher-level social inferences whereas vermal/medial sectors are involved in basic perceptual emotional mechanisms. We found that interfering via TMS with activity of the medial cerebellum significantly impaired basic emotional recognition/discrimination. In turn, only TMS over the lateral cerebellum affected a task requiring recognizing an emotion considering the social context in which it was experienced. Overall, our data support the existence of a medial-to-lateral gradient in the posterior cerebellum, with medial sectors supporting basic emotion recognition and lateral sectors being recruited when the task taps on higher inferential processing/mentalizing. Interestingly, the contribution of the cerebellum in these different processes seems to be restricted to negative emotional stimuli.Significance Statement:The cerebellum has been recently recognized as a critical component of the social brain, however, the functional topography of this structure in relation to social and emotional processes is still debated. By adopting a causative approach through the use of transcranial magnetic stimulation, the present study critically insights into the functional organization of the posterior cerebellum by testing the hypothesis of a medial-to-lateral gradient that reflects increasing complexity of social cognitive processes. Our findings demonstrate that lateral and medial cerebellar regions exert partially distinguishable functions in the social cognitive domain, with the medial cerebellum that mainly mediates basic perceptual emotional mechanisms while the lateral cerebellum, although supporting more basic functions, further subserves higher-level social operations.