bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic Effect of San-Zi-Yang-Qin Decoction on Obese Pre-hypertension: A Non-targeted Combined with Pseudo-targeted Metabolomics
Authors: li shumin , Dong Meiyue , Jiang Haiqiang , Li Yunlun , Qi Dongmei 
Published: July 2023

Abstract

Background Evaluation of the intervention effect of SZD on high-fat and high-salt induced obese Pre-hypertension rats from the perspective of metabolomics, and to explore the metabolic mechanism of SZD for the treatment of obese Pre-hypertension Methods In this study, the efficacy of SZD was evaluated by blood pressure, body weight, Lee’s index, and biochemical indexes, and the mechanism of SZD in the treatment of obese prehypertensive rats induced by high-salt the high-fat mode was explored through non-targeted metabolomics combined with pseudo-targeted metabolomics. Results SZD intervention reduced systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial pressure, and reduced body weight and Lee's index in rats, which had some improvement effect on obesity. It also reduced triglyceride(TG), total cholesterol(TC), Low-density lipoprotein cholesterol(LDL),Hypersensitivity C-reactive protein(Hs-CRP) levels in rats, but had no significant elevation effect on High-density lipoprotein cholesterol(HDL). Analysis of 35 biomarkers in the model and 31 biomarkers in the SZD intervention by non-targeted metabolomics revealed that SZD interfered with 7 of these metabolites (estradiol, sphingosine, TXB2, LysoPC (20:2), LysoPE (22:0), LysoPC (22:5), LysoPC (20:0)). The further content analysis of 7 metabolites by pseudo-targeted metabolomics revealed an increase in estradiol and sphingomyelin,and a decrease in LysoPC (20:2), LysoPE (22:0), LysoPC (22:5), and LysoPC (20:0) after SZD intervention, which involved in glycerophospholipid metabolism, sphingolipid metabolism, linoleic acid metabolism, and arachidic acid metabolism. Conclusions SZD was finally found to improve obesity and decreased blood pressure.The preliminary investigation of the efficacy mechanism of SZD intervention in obese Pre-hypertension enriched the pharmacological effects of SZD.
SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss
Authors: Spits Claudia , Lei Yingnan , Delbany Diana Al , Krivec Nuša , Regin Marius , de Deckersberg Edouard Couvreu , Janssens Charlotte , Ghosh Manjusha , Sermon Karen 
Published: July 2023

Abstract
Human pluripotent stem cell (hPSC) cultures are prone to genetic drift, as cells that have acquired specific genetic abnormalities experience a selective advantage in vitro. These abnormalities are highly recurrent in hPSC lines worldwide, but currently their functional consequences in differentiating cells are scarcely described. An accurate assessment of the risk associated with these genetic variants in both research and clinical settings is therefore lacking. In this work, we established that one of these recurrent abnormalities, the loss of chromosome 18q, impairs neuroectoderm commitment and affects the cardiac progenitor differentiation of hESCs. We show that downregulation of SALL3, a gene located in the common 18q loss region, is responsible for failed neuroectodermal differentiation. Knockdown of SALL3in control lines impaired differentiation in a manner similar to the loss of 18q, while transgenic overexpression of SALL3 in hESCs with 18q loss rescued the differentiation capacity of the cells. Finally, we show by gene expression analysis that loss of 18q and downregulation of SALL3 leads to changes in the expression of genes involved in pathways regulating pluripotency and differentiation, including the WNT, NOTCH, JAK-STAT, TGF-beta and NF-kB pathways, suggesting that these cells are in an altered state of pluripotency.
Pedicled ALT-flap for soft tissue reconstruction in the trochanteric area
Authors: Vater Adrian , Moncher Johanna , Schmidt Karsten , Jordan Martin , Jakubietz Michael , Meffert Rainer , Jakubietz Rafael 
Published: July 2023

Abstract

Purpose: Coverage of soft tissue defects following surgery at the trochanteric area is challenging. Revision surgery in case of compromised wound healing may lead to soft tissue defects requiring reconstruction with pedicled or free flaps. Previous access to the hip joint may jeopardize neurovascular structures relevant to the flap. In this study, we evaluated if pedicled anterior lateral thigh (ALT) flap is a valueable option for soft tissue reconstruction in this situation.
Methods: In this retrospective study, five patients were included. Defect etiology was tumor resection in one case, screw osreosynthesis in another case and total hip arthroplasty in three cases. All patients underwent reconstruction by proximal pedicled anterior lateral thigh (ALT) flap.
Results: Pedicled ALT flap was a safe procedure in all cases. One patient showed delayed wound healing with need for additional surgery. No further complications were observed.
Conclusion: Pedicled ALT flap transfer represents a reliable option for soft tissue coverage in the trochanteric area after primary surgery such as hip arthroplasty, osteosynthesis or tumor resection.
Long-term effect of municipal solid waste compost on the recovery of a potentially toxic elements (PTEs)-contaminated soil: PTEs mobility, distribution and bioaccessibility
Authors: Caporale Antonio Giandonato , Porfido Carlo , Roggero Pier Paolo , Palma Anna Di , Adamo Paola , Pinna Maria Vittoria , Garau Giovanni , Spagnuolo Matteo , Castaldi Paola , Diquattro Stefania 
Published: July 2023

Abstract

Compost from municipal solid waste (MSWC) can represent a resource for the environmental management of soils contaminated with potentially toxic elements (PTEs), since it can reduce their mobility and improve soil fertility. However, the long-term impact of compost on soil recovery has been poorly investigated. To this end, the influence of a MSWC added at different rates (i.e. 1.5, 3.0 and 4.5% w/w) to a multi PTEs-contaminated (e.g. Sb 412 mg kg-1, Pb 2664 mg kg-1, and Zn 7510 mg kg-1) sub-acidic soil (pH 6.4) was evaluated after 6 years since its addition. The MSWC significantly enhanced soil fertility parameters (i.e. total organic carbon, Olsen-P and total N) and reduced the PTE labile fractions. The distribution maps of PTEs detected through μXRF analysis revealed the presence of Zn and Pb carbonates in the amended soils, or the formation of complexes between these PTEs and the functional groups of MSWC. A higher oral, inhalation and dermal bioaccessibility of each PTE was detected in the soil fine-grained fractions (<2 and 2-10 µm) than in coarse particles (10-20 and 20-50 µm). The MSWC amendment generally did not modify the PTEs bioaccessibility; while the relative bioaccessibility of cationic PTEs was greater than that of anionic ones (e.g. Cd> Zn> Pb> Sb> As). Pb and Sb showed the highest Hazard Quotients (e.g. 2.2 and 10 for Sb and Pb, respectively, in children). Overall, the results indicated that the MSWC used can be an effective option for the recovery of PTEs-contaminated soils, even in the long term.
Is Dispatcher-Assisted Cardiopulmonary Resuscitation Affected By a Bystander's Emotional Stress State in Out-of-hospital Cardiac Arrest?
Authors: Tuffley Rebecca Hvidt , Folke Fredrik , Ersbøll Annette Kjær , Blomberg Stig Nikolaj Fasmer , Linderoth Gitte 
Published: July 2023

Abstract
Aim The study aimed to investigate whether a bystander’s emotional stress state affects dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) in out-of-hospital cardiac arrest (OHCA). The primary outcome was initiation of chest compressions (Yes/No). Secondarily we analysed time until chest compressions were initiated and assessed how the dispatcher instructed CPR.
Method The study was a retrospective, observational study of OHCA emergency calls from the Capital Region of Denmark. Recorded calls were evaluated by five observers using a pre-defined code catalogue regarding the variables wished investigated.
Results Included were 655 OHCA emergency calls, of which 211 callers were defined as emotionally stressed. When cardiac arrest was recognized, chest compressions were initiated in, respectively, 76.8% of cases with an emotionally stressed caller and 73.9% in cases with a not emotionally stressed caller (2.18 (0.80-7.64)). Cases with an emotionally stressed caller had a longer time until chest compressions were initiated compared to cases with a not emotionally stressed caller, however non-significant (164 sec. vs 146 sec.; P=0.145). The dispatchers were significantly more likely to be encouraging and motivating, and to instruct on speed and depth of chest compressions in cases with an emotionally stressed caller compared to cases with a not emotionally stressed caller (1.64 (1.07-2.56); 1.78 (1.13-2.88)). Barriers to CPR were significantly more often reported in cases with an emotional stressed caller compared to cases with a not emotional stressed caller (1.83 (1.32-2.56).
Conclusion There was no significant difference in initiation of chest compressions or in time until initiation of chest compressions in the two groups. However, the dispatchers were overall more encouraging and motivating, and likely to instruct on speed and depth of chest compressions when the caller was emotionally stressed. Furthermore, barriers to CPR were more often reported in cases with an emotional stressed caller compared to cases with a not emotional stressed caller.
TRIAL REGISTRATION
We applied for ethical approval from The Danish National Committee on Health Research Ethics, but formal approval was waived. We received permission for storage of data and to use these for research of OHCAs in the Capital Region of Denmark by Danish Data Protection Agency (P-2021-670) and Danish Health Authorities (R-2005114). The study is registered at ClinicalTrials (NTC05113706).
Real-time comparison of terlipressin vs. octreotide as an adjuvant treatment in the management of variceal bleeding
Authors: Rehman Hareem , Rehman Syed Tabish , Zulfiqar Shahzana , Awan Safia , Abid Shahab 
Published: July 2023

Abstract
Variceal bleeding is a major complication and the leading cause of death in patients with cirrhosis and portal hypertension. This study aims to compare the efficacy and safety of Terlipressin vs octreotide as an adjuvant to endoscopic management of patients with esophageal variceal bleeding in a real-time scenario. We reviewed the medical records of patients with esophageal variceal bleeding from January 2005 to December 2020 at our tertiary care Aga Khan University Hospital. Mortality was assessed after 6 weeks. A total of 842 patients with variceal bleed were evaluated. 624 patients (74.1%) and 218 patients (25.9%) received Terlipressin and Octreotide respectively. On multiple regression analysis, cardiac events during hospital stay (OR: 11.22), presence of Porto-systemic encephalopathy (OR: 3.79), and elevated bilirubin levels at the time of presentation were found to be independent risk factors for increased six weeks mortality. Moreover, cardiac events during hospital stay (OR: 3.26), Porto-systemic encephalopathy at presentation (OR: 3.06), and octreotide administration (OR: 1.80) were identified as independent risk factors for increased length of hospital stay. Terlipressin and Octreotide have similar outcomes in terms of control of bleeding, hospital stay, mortality, and side effects when used as adjuvant therapy for the management of variceal bleeding.
Relationship between early life asthma and chronic airway disease in adult life – in search for disease trajectories over the life span - The RELATE study based on the Kongsberg cohort
Authors: Savran Osman , Bønnelykke Klaus , Ulrik Charlotte Suppli 
Published: July 2023

Abstract
Background: Chronic airway disease in adults may have its origin in early life. The purpose of this study is to investigate the long-term prognosis of severe childhood asthma in search for an association between asthma in early life and obstructive lung disease in adulthood.
Methods: This study is based on the Kongsberg cohort, which includes approximately 5000 children with severe asthma with a 4-month stay at the asthma care facility in Kongsberg, Norway during the years 1950 to 1979. An on average 60-year follow-up examination will be performed including questionnaires, blood samples, and tests of lung function and bronchial responsiveness. Blood samples will be stored in a biobank. In addition, we will conduct further analyses of the cohort based on nationwide register data, including socio-economic parameters and mortality.
Discussion: Chronic airway disease is associated with substantial burden for both the individual patient and society. Our knowledge of early life origins of chronic airway disease later in life has been increasing in recent decades but is still limited. By exploring early life risk factors for chronic airway disease in adulthood, we may gain insights paving the way for future reduction in the burden of chronic airway diseases.
Prediction Model of mental health of Middle-aged and older adults in China
Authors: Li Yong , Kong Lingrui 
Published: July 2023

Abstract

The phenomenon of aging has emerged as a prominent concern within the context of China's economic and social progress. The middle-aged and elderly population suffers the dual burden of psychological and physiological challenges due to the decline in their physiological functions. However, the intricate nature of mental health diagnostic analysis poses difficulties in early predicting and intervening in mental health issues affecting middle-aged and elderly individuals. We attempt to establish a benchmark for evaluating the mental health of middle-aged and older adults based on psychological theories. Additionally, we propose a hypergraph-based mental health prediction model, termed MH-HGNN, specifically designed for this demographic. MH-HGNN incorporates a hypergraph structure to capture and process complex high-order correlation relationships by representing middle-aged and elderly individuals as nodes. By applying Laplace polynomial spectral convolution representation learning on these relationships, the model forecasts the mental health status of this population segment. Empirical findings indicate that MH-HGNN achieves an 82.7% accuracy rate in predicting mental health outcomes, surpassing the performance of prevalent deep learning baseline techniques like GNN, GAT, and GraphSAGE. Notably, the MH-HGNN model exhibits an improvement of up to 9.17% in accuracy compared to the baseline model.
Long term efficacy of three chitin synthesis inhibitors and oxymatrine as cowpea seed protectants against Callosobruchus maculatus and Callosobruchus chinensis
Authors: Gad Hassan A. , Al-Ayat Adel A. , Mohamed Hamdy A. , Abdelgaleil Samir A.M. 
Published: July 2023

Abstract
The residual efficacy of three chitin synthesis inhibitors (CSIs) (chlorfluazuron, hexaflumuron and lufenuron) and oxymatrine at an application rate of 5.0 mg/kg was evaluated against Callosobruchus maculatus and Callosobruchus chinensis monthly for 5 consecutive months (6 bioassays). In each bioassay, the mortality of two insect adults was counted after 7 days, progeny reduction and cowpea weight loss percentages were recorded after 45 days. Our results revealed that CSIs caused high level of adult mortality of both insects and oxymatrine caused a complete adult mortality (100%) for five months storage. The tested CSIs produced a significant progeny reduction of C. maculatus and C. chinensis but did not achieve a complete reduction of F1 progeny during all storage periods. A complete progeny suppression of two insects and full cowpea seed protection were observed in all oxymatrine treatments during the entire storage periods. A remarkable protection of cowpea seeds was also achieved in the treatments with CSIs particularly chlorfluazuron during the first 3 months. These findings indicate CSIs and oxymatrine could be implemented in IPM of these insects.
Does Mandibular Osteotomy Affect the Infraorbital Nerve? A Prospective Study
Authors: Ak Kıvanç Berke , Özel Abdullah , Süzen Muazzez , Uçkan Sina 
Published: July 2023

Abstract
Objectives
The aim of this study was to evaluate the sensory function of the infraorbital nerve after orthognathic surgery (OS) .
Materials and methods
Patients who underwent Le Fort I osteotomy with or without BSSO for dentofacial deformity treatment were studied. Two groups were created according to whether BSSO was performed. Class A tests were performed to determine the degree of peripheral nerve damage. The Class B test was performed if decreased sensation was detected in at least one of these tests. A Class C test was performed if abnormal sensation was detected.
Results
Twenty-eight patients (n = 56) who underwent OS were included in this prospective study. Of the patients, 57.1% were female, 42.9% were male, and the mean age was 24.6 (± 3.8). Seven patients were in group 1 (n = 14), and 21 patients were in group 2 (n = 42). In both groups, there were statistically significant differences between T1 and T2 (p < 0.001), and the mean NSD score at T2 was higher than that at T1. The mean NSD score in the single jaw group was higher than that in the double jaw group at all time points.
Conclusions
Bimaxillary surgeries had a negative effect on the somatosensory changes that developed in the early period. The upper lip’s somatosensorial recovery was faster than IOR and single jaw recovery was faster than double jaw.
Clinical relevance:
Maxillofacial surgeons performing orthognathic surgery should be aware that in double jaw operations, changes in the somatosensory function of the ION are more severe.
An Empirical Study of the Influences of Gustiness on Vertical Mixing in Air-sea Boundary Layer
Authors: lyu Meng , Potter Henry , Ortiz-Suslow David , Wang Qing , Wang Xiaoqi 
Published: July 2023

Abstract
The exchange of momentum across the air-sea interface is a key driver of the earth system and its accurate parameterization is essential for precise weather and climate forecasting. However, our understanding of gustiness as an independent factor that can contribute to the momentum flux is still limited. Using data collected from the R/P FLIP, as part of the Couple Air-sea Processes and Electromagnetic Ducting Research (CASPER) experiment, we explored the mechanisms by which gustiness contributes to the total interfacial momentum flux. We investigate how gustiness affects both the temporal and spatial (vertical) variance of turbulence in the atmospheric surface layer. We identified that high gustiness was associated with strong anisotropic turbulence at each measurement height. This was found to increase vertical wind fluctuations and inject additional momentum across the air-sea interface at lower wind speeds. Increased gustiness was founded associated with the breakdown of the constant flux layer, which is generally assumed valid over the ocean. The study of gustiness presented in this paper has implications for both momentum flux parameterization and the use of similarity theory to model the flux-gradient relationship in the gusty atmospheric surface layer, thereby influencing the forecasting of climate and extreme weather events.
Risk Assessment of multiple mycotoxins and trace metals through mother milk consumption to neonates in India
Authors: Maurya Kamlesh , Mandal Payal , Saifi Ishrat J. , Shukla Aditya , Naseem Mariya , Dixit Sumita , Srivas Pankaj K. , Yadav Akhilesh K. , Verma Sanjeev K. , Ansari Kausar M 
Published: July 2023

Abstract
Mother’s milk is a unique biological fluid providing essential nutrients for the proper growth and development of neonates. Surveillance reports indicated continuous exposure to various contaminants to humans. These xenobiotics tend to mobilize into multiple body fluids, including mother’s milk, thus creating a higher risk to mother’s milk-fed neonates. This study aimed to determine the extent of mycotoxins, trace and toxic metals contamination in mother’s milk, and health risk assessment of mother’s milk-dependent neonates. In this study, mycotoxins and metals were analyzed in the milk of 100 Indian nursing mothers. Aflatoxin M1(AFM1) was detected by ELISA, whereas Ochratoxin (OTA), α-Zearalenol(α-ZEL), β-Zearalenol (β-ZEL) and Zearalenone (ZEN) were analyzed by LC-HRMS. Metals were analyzed using ICP-MS. In the 100 analyzed samples, the detection of AFM1, OTA, ZEN, α-ZEL, and β-ZEL were 73%, 96%, 30%, 15%, and 7%, respectively. In breastfed infants, the estimated daily intake (EDI) of AFM1, OTA, and ZEN were 0.005, 0 0.047, and 0.024 µg/L BW/day. Similarly, metals analysis showed the presence of Cr, Mn, As, Cd, and Pb were 26%, 49%, 42%, 34%, and 12%, respectively. The HQ > 1 in arsenic indicates possible health risks for the infants. A significant correlation was found among all metals except As. α-ZEL, β-ZEL, and ZEN were significant among themselves. Altogether, results suggest a potential risk of mycotoxins and trace toxic metals for neonates via mother’s milk which requires immediate attention and must be regulated promptly.
Outpatient orthognathic surgery: a prospective study of predictive factors for the length of hospital stays.
Authors: Prevost Alice , Lauwers Frédéric , Varazzani Andréa , Poulet Vinciane , Mure Marion , Lopez Raphael , Cavallier Zoé 
Published: July 2023

Abstract
Objectives
Transitioning from non-outpatient orthognathic surgery to outpatient surgery is a new challenge, and it is essential to target the eligible population as precisely as possible. Several authors describe series of outpatient orthognathic surgery but do not include the reasons for their success or failure.
The main aim of this study was to identify the factors significantly associated with "successful" outpatient orthognathic treatment.
The secondary objective was to determine the factors significantly associated with prolonged hospital stays (≥ 2 nights).
Materials & Methods:
A prospective cohort study including patients undergoing orthognathic surgery was conducted over a period of 1 year. We recorded the prognostic factors that contributed to successful outpatient treatment and prolonged hospital stays. These factors were evaluated by bivariate and multivariate analysis.
Results:
102 patients were included and the success rate of treatment was 65%. The variables that were isolated by multivariate analysis were: patients over the age of 22, procedures ending before 1 pm, brief operations, the absence of both postoperative vomiting and the administration of morphine.
Conclusion:
Patient selection, organisation of outpatient facilities and anaesthetic protocols contribute to the development of outpatient orthognathic surgery. These initial considerations provide a framework for our practice, but the considerations that predict the failure of outpatient surgery will need to be clarified.
Clinical Relevance:
Orthognathic surgery can be performed on outpatient basis in selected cases. Age, the operative time, procedure end time, postoperative vomiting and the administration of morphine are associated with the success of outpatient care.