bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amniotic fluid stem cell extracellular vesicles as a novel fetal therapy for pulmonary hypoplasia: a review on mechanisms and translational potential
Authors: Doktor Fabian , Antounians Lina , Figueira Rebeca Lopes , Khalaj Kasra , Duci Miriam , Zani Augusto 
Published: January 2025

Abstract
Disruption of developmental processes affecting the fetal lung leads to pulmonary hypoplasia. Pulmonary hypoplasia results from several conditions including congenital diaphragmatic hernia (CDH) and oligohydramnios. Both entities have high morbidity and mortality, and no effective therapy that fully restores normal lung development. Hypoplastic lungs have impaired growth (arrested branching morphogenesis), maturation (decreased epithelial/mesenchymal differentiation), and vascularization (endothelial dysfunction and vascular remodeling leading to postnatal pulmonary hypertension). Herein, we discuss the pathogenesis of pulmonary hypoplasia and the role of microRNAs (miRNAs) during normal and pathological lung development. Since multiple cells and pathways are altered, the ideal strategy for hypoplastic lungs is to deliver a therapy that addresses all aspects of abnormal lung development. In this review, we report on a novel regenerative approach based on the administration of extracellular vesicles derived from amniotic fluid stem cells (AFSC-EVs). Specifically, we describe the effects of AFSC-EVs in rodent and human models of pulmonary hypoplasia, their mechanism of action via release of their cargo, including miRNAs, and their anti-inflammatory properties. We also compare cargo contents and regenerative effects of EVs from AFSCs and mesenchymal stromal cells (MSCs). Overall, there is compelling evidence that antenatal administration of AFSC-EVs rescues multiple features of fetal lung development in experimental models of pulmonary hypoplasia. Lastly, we discuss the steps that need to be taken to translate this promising EV-based therapy from the bench to the bedside. These include strategies to overcome barriers commonly associated with EV therapeutics and specific challenges related to stem cell-based therapies in fetal medicine.
The Role of Reflection for Continuing Professional Development of In-Service Health Care Professionals: A Narrative Inquiry in Four Health Professions
Authors: Fernandez Nicolas , Aloisio Alves Camila , Tremblay Frédéric , Belisle Marilou , Vachon Brigitte , Kathleen Lechasseur , Caty Marie-Ève 
Published: January 2025

Introduction:
Health care providers (HCPs) use reflection to intervene in complex, ambiguous clinical situations. Yet, there is scant evidence about the circumstances when HCPs use reflection and how they perceive reflection within their continuing professional development. We selected a narrative inquiry approach to study how HCPs perceive reflection's role in learning in four health professions.

Methods:
We invited 26 health professionals to a narrative interview conducted by a student in one of the four selected professions: medicine, nursing, occupational therapy, and speech-language pathology. The narrative events that make up the stories were analyzed and interpreted using structural analysis based on the narratives' historic-empirical and psycho-semantic dimensions.

Results:
Physicians told us that reflection bolsters their clinical performance and confidence. Nurses told us that reflection allowed them to develop resilience as they sought to integrate their work setting and gain autonomy. Occupational therapists spoke of how reflection spurred them to innovate and extend the scope of their practice to advocate for their patients' health better. Speech-language pathologists described how they reflect on “educating” other HCPs about their profession and enhancing their communication skills with patients.

Discussion:
The communicative power of storytelling allowed us to fathom what is hard to describe in words: how reflection builds clinical and psychosocial skills and introspective capacity. Hence, findings provide empirical evidence of reflection's perceived role in maintaining professional skills that make HCPs effective in complex, ambiguous situations.
COVID-19 Symptoms Only Minutely Influenced by Genes Among Children in a Nationwide Twin Cohort
Authors: Hedman Anna M. , Palm Camilla , Magnusson Patrik K. E. , Rhedin Samuel A. , Kuja-Halkola Ralf , Almqvist Catarina 
Published: January 2025

Background:
The World Health Organization classified coronavirus disease (COVID-19) as a pandemic by March 11, 2020. Children had a milder disease than adults, and many were asymptomatic. The pandemic could be seen as a natural experiment with several changes, including time spent at home. The relative influence of genes and environment on the variability of a trait can be studied using twin pairs. We aimed to investigate the occurrence of reported COVID-19 symptoms and to separate the relative influence of genes and environment on these traits by variance decomposition.

Methods:
This was a population-based twin study conducted between November 2020 and March 2023. A survey was sent out to all parents of 9-year-old twins containing questions related to suspected COVID-19, symptoms of cough, fever and rhinorrhea, as well as concerns for their own and others’ health. Twin modeling with variance decomposition was used to separate the relative influence of genes and environment.

Results:
In total, 3094 individuals from 1547 complete twin pairs were included (618 monozygotic and 929 dizygotic twin pairs). Suspected COVID-19 increased over time and concerns for own and others’ health decreased. We found variability to be attributed mainly to shared environment in all traits investigated ranging between 63.0% and 86.2%. The rest of the variance of each trait was attributed to genetic factors (11.6%–33.5%) and nonshared environment (2.1%–9.9%).

Conclusions:
We found results of substantial shared environment in all traits analyzed among 9-year-old twins. Age and timing seem crucial when investigating the possible influence of genes and the environment when a new virus is introduced before herd immunity is reached.
Prevalence and Predictors of Thirst in Patients With Heart Failure
Authors: Younes Kamar , Massouh Angela , Deek Hiba , Nasreddine Lara , Waldréus Nana , Noureddine Samar 
Published: January 2025

Background
Thirst is among the most unpleasant symptoms in patients with heart failure (HF). Intense thirst can lead to uncontrolled fluid intake, resulting in congestion and frequent readmissions. Many predictors of thirst were identified, but little research addressed its association with salt intake.

Objective
The aims were to describe the prevalence and characteristics of thirst in patients with HF, examine its association with salt intake, and identify its predictors.

Methods
Using a descriptive correlational design, 100 patients with New York Heart Association classes I, II, and III HF were interviewed about thirst, salt-related behaviors, and the Patient Health Questionnaire-2. Demographic and clinical information were extracted from medical records. Descriptive statistics as well as bivariate and multivariable regression analyses were used.

Results
Most participants were male and married, with university education and a mean age of 66.7 ± 13.2 years. The mean thirst intensity score was 3.81 ± 2.17 (out of 10), and its prevalence was 93%. The mean thirst distress score was 23.58 ± 7.66 (out of 40); 68% reported moderate or strong distress. Patients prescribed salt restriction had lower thirst intensity (3.60 vs 5.70, P = .003) than their counterparts and thirst distress (22.78 vs 27.50, P = .062) that approached significance. Salt restriction; use of statins, antidepressants, and any renin angiotensin aldosterone system (RAAS) blocker; and Patient Health Questionnaire-2 score predicted thirst intensity. Female sex as well as use of any RAAS blocker and antidepressants predicted thirst distress.

Conclusions
Thirst was prevalent, distressing, and predicted by salt restriction, use of any RAAS blocker, and depression. Assessing thirst and relieving it are recommended.
Improved Items for Estimating SF-36 Profile and Summary Component Scores
Authors: Ware John E. 
Published: January 2025

Background:
Comprehensive health-related quality of life (QOL) assessment under severe respondent burden constraints requires improved single-item scales for frequently surveyed domains. This article documents how new single-item-per-domain (SIPD) QOL General (QGEN-8) measures were constructed for domains common to SF-36 and results from the first psychometric tests comparing scores for the new measure in relation to those for the SF-36 profile and summary components.

Research Design:
Online NORC surveys of adults, ages 19–93 (mean=52 y) representing the US population in 2020 (N=1648) included QGEN-8 and SF-36 items measuring physical (PF), social (SF), role physical (RP) and role emotional (RE) functioning and feelings of bodily pain (BP), vitality (VT), and mental health (MH). QGEN-8 items were constructed with response categories increasing score ranges for functioning (PF, SF, RP, RE) and directly measuring first-order factors for feelings (BP, VT, and MH). Analyses compared ceiling effects, convergent-discriminant correlations, classic and confirmatory factor analysis (CFA) testing for higher-order physical and mental components, and validity in discriminating across groups differing in comorbid condition severity.

Results:
QGEN-8 reduced response times by 75% and lowered ceiling effect percentages (−2.2% to −27.8%, median=−14%) in comparison with SF-36. Their common measurement model was supported by: (1) substantial convergent correlations (r=0.576–0.778, median r=0.721) between methods for all domains; (2) lower discriminant correlations between different domains; (3) patterns of factor loadings equivalent to previous studies and adequate CFA model fit; (4) high correlations between methods for physical (r=0.813) and mental (r=0.761) component scores; and (5) equivalent average declines across groups reporting worse comorbid conditions.

Conclusions:
Overall, results support the use of QGEN-8 to reduce respondent burden and ceiling effects while maintaining convergent and discriminant validity sufficient to estimate group-level SF-36 physical (PCS) and mental (MCS) summary scores. To facilitate its use, QGEN-8 has been made available in multiple languages from the non-profit Mapi Research Trust at https://eprovide.mapi-trust.org.
Change Over Time in Hospital Care for Medicaid Beneficiaries
Authors: Xu Jacqueline , Hodis Jeffrey D. , Calderon Kary , Chung Paul J. , Nocon Robert S. 
Published: January 2025

Background:
Historically, access to high-quality care has been a central challenge for Medicaid programs. Prior single-year analyses demonstrated that Medicaid beneficiaries account for disproportionately high patient volumes at low-quality hospitals. Given major Medicaid shifts including expansion and increased managed care, we examined recent trends in low-quality hospital use for Medicaid beneficiaries.

Methods:
Using Healthcare Cost and Utilization Project State Inpatient Databases, we compiled adult hospital discharges from 15 states in years 2016–2019 (N=32,788,446). Hospital quality was assessed with the Agency for Healthcare Research and Quality (AHRQ) Composite Inpatient Quality Indicator, reflecting risk-adjusted mortality for prevalent conditions. We constructed a logistic regression modeling odds of discharge from a low-quality hospital (bottom 20th percentile by year), with payer-year interactions and covariates for patient demographics (sex, age, race/ethnicity, income), comorbidities, state, and hospitalization type.

Results:
Overall, patients with Medicaid [adjusted odds ratio (aOR)=1.11, P<0.01] or Medicare (aOR=1.03, P<0.01) were more likely to be hospitalized in low-quality hospitals, compared with private insurance (reference). The likelihood of admission to low-quality hospitals over time varied by payer. Patients insured by Medicaid were 2% less likely to be admitted to low-quality hospitals each additional year (aOR=0.98, P<0.01). Medicare-insured patients did not show significant changes longitudinally, and privately insured patients were 3% more likely to be admitted to low-quality hospitals each year (aOR=1.03, P<0.01).

Conclusions:
This is one of the first studies examining associations between payer and inpatient care quality over time, critical for our rapidly changing payment environment. Although Medicaid-insured patients remain more likely to be discharged from low-quality hospitals as compared with other payers, we find promising recent trends of improving hospital quality over time for Medicaid beneficiaries.
Analysis of the interactions between physiological substances and endogenous hormones inBombax ceibabud differentiation
Authors: Wang Shuyu , Cai Zeping , Zhao Ying , Cui Deqiao , Wang Meixing , Zhang Yanting , Yu Xudong 
Published: January 2025

2AbstractPlant bud differentiation is a process of transition from nutrient growth to reproductive growth, which is important for improving crop yield, breeding of good seeds and regulation of flowering time. To elucidate the morpho-physiological changes during bud differentiation inBombax ceiba, this study was conducted in Haikou City, Hainan Province, employing paraffin sectioning, plant physiological assays, and LC-MS. We aimed to determine the dynamic changes occurring during this process. The results showed that 1) firstly, the transformation from growth point to flower bud is called floral primordial development, and secondly, the floral organ is mature.2) The content of soluble sugar and soluble starch of early-flowering and late-floweringBombax ceibafirst increased and then decreased, and the content of sucrose, soluble protein and malondialdehyde first decreased and then increased. The content of chlorophyll a gradually decreased and that of chlorophyll b and carotenoids gradually increased in early-floweringBombax ceiba, while the opposite was true in late-floweringBombax ceiba.3) 5Ds, CK and Auxin mainly acted in stage I and II, and ABA, SA, GA, ETH, and JA mainly acted in stage II and III.4) Soluble sugar and GA, soluble protein and IAA\CK, sucrose\malondialdehyde and IAA\CK\JA, soluble starch and IAA\CK\GA were significantly positively correlated, and chlorophyll and IAA\CK\SA were significantly negatively correlated, with the existence of synergistic and antagonistic effects co-regulating bud differentiation.This study provides a theoretical basis for exploring the mechanism of flower formation inBombax ceibaand production practice.3Summary statementTo investigate the morphological and physiological characteristics of the bud differentiation process inBombax ceiba, and to reveal the mechanisms of physiological substances and hormone interactions.
Solvable entanglement dynamics in quantum circuits with generalized space-time duality
Authors: Liu Chuan , Ho Wen Wei 
Published: January 2025

We study the nonequilibrium dynamics of kicked Ising models in 1 + 1 dimensions which have interactions alternating between odd and even bonds in time. These models can be understood as quantum circuits tiling space-time with the generalized space-time dual properties of triunitarity (three “arrows of time”) at the global level, and also second-level dual unitarity at the local level, which constrains the behavior of pairs of local gates underlying the circuit under a space-time rotation. We identify a broad class of initial product states wherein the effect of the environment on a small subsystem can be exactly represented by influence matrices with simple Markovian structures, resulting in the subsystem's full dynamics being efficiently computable. We further find additional conditions under which the dynamics of entanglement can be solved for all times, yielding rich phenomenology ranging from linear growth at half the maximal speed allowed by locality, followed by saturation to maximum entropy (i.e., thermalization to infinite temperature), to entanglement growth with saturation to extensive but submaximal entropy. Intriguingly, for certain parameter regimes, we find a nonchaotic class of dynamics which is neither integrable nor Clifford, exemplified by nonzero operator entanglement growth but with a spectral form factor which exhibits large, apparently time-quasiperiodic revivals.

Published by the American Physical Society
2025
Platform digitization capability and organizational resilience: examining the roles of resource reconfiguration and environmental munificence
Authors: Li Xiadi , Lin Hanchuan 
Published: January 2025

PurposeDespite the importance of platform digitization capability to established firms, empirical research related to platform digitization capability, resource reconfiguration and organizational resilience remains scarce. Based on resource action view and contingency theory, this study constructs an integrated theoretical framework to examine the mediation effect of resource reconfiguration and the moderation effect of environmental munificence in the relationship between resource reconfiguration and organizational resilience.Design/methodology/approachSurvey data comprising 312 valid responses are collected from manufacturing firms in China. Partial least squares equation modeling (PLS) was used in this study to test the hypotheses.FindingsResults showed that platform digitization capability is positively related to organizational resilience. Resource recombination and resource reallocation mediate the platform digitization capability–organizational resilience relationship. Furthermore, environmental munificence significantly strengthens the relationship between resource recombination and organizational resilience while weakens the relationship between resource reallocation and organizational resilience.Originality/valueThis study reveals the path of platform digitization capability affecting organizational resilience, discusses the different role of resource recombination and resource reallocation and makes incremental contributions to resource action view. It also studies the impact of resource reconfiguration on organizational resilience under the condition of environmental munificence, which provides a new perspective for the study of organizational resilience and enriches the application of contingency theory in the crisis context.
The role of online communities in shaping the Society 5.0 paradigm: a social capital perspective
Authors: Ancillai Chiara , Bartoloni Sara , Filipovic Jelena , Temperini Valerio 
Published: January 2025

PurposeThe study’s purpose is to understand how online communities, thanks to their knowledge-sharing potential, can help to achieve the principles of a human-centered society. The social capital theory is applied to understand knowledge contribution and knowledge sharing in online communities.Design/methodology/approachA qualitative approach based on a single case study of an international online community is adopted.FindingsThe case study highlights how each social capital facet unfolds within the online community to model efficient knowledge exchange among members. The developed social capital generates benefits at three interconnected system levels: micro (individuals), meso (companies), and macro (society).Originality/valueThe paper makes several contributions to the literature on Society 5.0, social capital theory, and knowledge management by bringing the needed empirical evidence on how to exploit online digital technologies to generate the benefits associated with Society 5.0. It also demonstrates that social capital theory is a valuable theoretical lens through which to explain how knowledge-sharing and exchange mechanisms in online communities contribute to shaping a human-centered society.
Prioritizing performance objectives of vaccine supply chain for future pandemics
Authors: Rai Pratik , Bera Sasadhar 
Published: January 2025

Purpose
The vaccine supply chain (VSC) performance remains under stress during pandemic outbreaks than conventional vaccination drives due to desired vaccination coverage. Therefore, it is essential to identify the crucial performance objectives (POs) and their interrelationship structure and prioritize them to improve performance in a pandemic VSC.

Design/methodology/approach
This study combines the decision-making trial and evaluation laboratory based analytic network process (DANP) method with spherical fuzzy sets (SFS) to explore critical POs of the pandemic VSC in the balanced scorecard framework. The SFS theory tackles the uncertainty of POs and DANP interlaced causal relationships among crucial POs to the pandemic VSC while ranking them for prioritization.

Findings
This work identifies 32 issues associated with pandemic VSC and maps them against 13 POs. Effective communication, adequate health financing and operating cost optimization are the most critical POs, and operational issues listed under them must be prioritized to improve the overall VSC performance for future pandemics. The relationship structure among these POs is also summarized using the balanced scorecard framework in a strategy map.

Research limitations/implications
The strategy map proposed in this study can help practitioners to address the causality among different POs and underlying issues for the sudden expansion of vaccination programs during pandemics from an economic, social and operational perspective.

Originality/value
To the best of the authors’ knowledge, this is the first empirical study to suggest improving the VSC performance during the pandemic by focusing on the causative relationship and priority of different detected POs.
Generative AI tools (ChatGPT*) in social science research
Authors: Sebastian Rigin , Kottekkadan Noufal Naheem , Thomas Toney K. , Niyas KK Mohammed 
Published: January 2025

Purpose
This paper aims to critically examine the implications of using generative artificial intelligence (AI) models, such as ChatGPT and Bard, in social science research. It examines the doppelganger effect in AI-driven studies as well as cognitive dissonance brought on by the autonomy of these tools. The discussion also addresses the debate between quantitative and qualitative methods for evaluating AI-driven research, scrutinising existing guidelines for accountability and validity. In addition, the paper considers the potential for generative AI to dominate research, identifying “non-takeoverable” skills and ethical issues in AI-driven knowledge production.

Design/methodology/approach
This work primarily focuses on research articles for conceptual clarity, while news media reports are used to illustrate current scenarios.

Findings
The doppelganger effect makes people worry about situations in which AI copies existing work so well that it becomes possible for people to give the wrong credit. This has led to a critical review of ways to make sure that the outputs of generative AI are real and original. Generative AI can enhance data collection and analysis, offering alternative approaches to traditional research methodologies. By leveraging the capabilities of generative AI, researchers can potentially uncover new insights and perspectives from their data.

Originality/value
It is crucial to acknowledge the ethical concerns associated with using generative AI in social science research. The deployment of such technology introduces the possibility of biases and other ethical challenges that may impact the cognitive abilities of human participants or researchers involved in the research process. The work makes an effort by encouraging ethical consideration and highlighting crucial human abilities that are still necessary, providing a novel viewpoint on the use of generative AI in research approaches.