bluuebunny/crossref_metadata_2025_split huggingface dataset:
A First Look at Childhood Abuse in Women with Obstructive Sleep Apnea
Authors: Pal Amrita , Martinez Fernando , Wagman Jennifer , Aysola Ravi S. , Shechter Ari , Mysliwiec Vincent , Martin Jennifer , Macey Paul M. 
Published: May 2023

Abstract
Study objectives. Women who experienced childhood sexual abuse have higher rates of obesity, a risk factor for obstructive sleep apnea (OSA). We assessed if prior childhood sexual abuse was more common in women with OSA vs. control, with possible mediation by obesity.
Methods. We studied 21 women with OSA (age mean±s.d. 59±12 years, body mass index (BMI) 33±8 kg/m2, respiratory event index [REI] 25±16 events/hour, Epworth Sleepiness Scale [ESS] 8±5) and 21 women without OSA (age 53±9 years, BMI 25±5 kg/m2, REI (in 7/21 women) 1±1 events/hour, ESS 5±3). We evaluated four categories of trauma (general trauma, physical, emotional, and sexual abuse) with the early trauma inventory self-report-short form (ETISR-SF). We assessed group differences in trauma scores with independent samples t-tests and multiple regressions. Parametric Sobel tests were used to model BMI as a mediator for individual trauma scores predicting OSA in women.
Results. Early childhood sexual abuse reported on the ETISR-SF was 2.4 times more common in women with vs. without OSA (p=0.02 for group difference). Other trauma scores were not significantly different between women with and without OSA. However, BMI was a significant mediator (p=0.02) in predicting OSA in women who experienced childhood physical abuse.
Conclusions. Childhood sexual abuse was more common in a group of women with OSA than those without OSA. Additionally, BMI was a mediator for OSA of childhood physical but not sexual abuse. There may be physiological impacts of childhood trauma in women that predispose them to OSA.
Effect of Genetic Variants, Gender, and Co-treatment on Olanzapine Plasma Concentration in Chinese patients with schizophrenia
Authors: Chen Binbin , Xu Xiangzhen , Lyu Haiyan , Cheng Gang 
Published: May 2023

Abstract
Purpose Given the inter-individual variability in dose-corrected concentrations observed in olanzapine used, this study aimed to find factors that may have contributed to the variation in patients.Methods The trough plasma concentrations of olanzapine were measured using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). All the patients enrolled were on steady olanzapine doses for at least two weeks. Our study simultaneously investigated the association of gender, co-treatment, kidney function, body weight, and UGT1A4, UGT2B7, UGT2B15, CYP1A2, CYP2D6 variants on olanzapine dose-corrected concentrations (C/DOLZ) in 117 Chinese patients with schizophrenia.Results Multiple linear regression analyses suggested that gender, co-treatment with sodium valproate, and UGT1A4 variants had significantly affected C/DOLZ in inpatients with schizophrenia (P༜0.05). Females showed higher C/DOLZ levels compared to males, co-treatment with VPA exhibited lower C/DOLZ levels, UGT1A4 variants showed its significance (P = 0.005) in the multiple linear regression,Conclusions The results revealed that gender, co-treatment with VPA, and UGT1A4 variants significantly influenced C/DOLZ levels. This study provided some combined effects, especially genotype and co-treatment information, for clinicians to remind them when prescribing OLZ. The variability of C/DOLZ levels suggests that TDM could be a helpful tool in addition to a thorough clinical follow-up.
Changes in dry spell durations associated with temperature warming and precipitation variations over the Indo-China Peninsula
Authors: Wu Xinqu , Luo Xian , Wang Fen , Yang Kaicheng , Wang Pengxiang 
Published: May 2023

Abstract
Dry spells have negative implications for water security and agriculture. Climate changes associated with increasing temperature and precipitation variations lead to changes in dry spell durations. The variability of the dry spell duration during the rainy season (May–October) over the Indo-China Peninsula (ICP) was analyzed, and the contributions of the temperature and precipitation changes with respect to the trend in the total duration of dry spells (TDDS) were quantified using linear regression methods. The results indicate increasing trend in the with a rate of 0.9 days/10 year over the entire ICP. Nevertheless, the trends presented great spatial variability, and 37.4% and 10.7% of the peninsula presented significant increasing and decreasing trends at the 95% confidence level, respectively. Climate warming has led to a considerable elongation of the dry spells during the rainy season at a rate of 5.3 days/°C, and areas with precipitation less than 1000 mm and higher than 2000 mm generally show faster increases. The change rates are clearly asymmetrically distributed with the dry spell duration, with hotter rainy seasons witnessing more frequent long-duration dry spells. On the other hand, considerable increasing precipitation shortens the dry spells, while decreasing precipitation facilitates the dry spell extension caused by rising temperatures. As the climate continues to warm, hotter rainy seasons will favor more frequent and prolonged dry spells, which will further exacerbate drought and heat waves over the ICP. These research results are expected to provide reference for agricultural activities, water resources management, and disaster prevention over the ICP.
Machine learning model for predicting late recurrence of atrial fibrillation after catheter ablation
Authors: Budzianowski Jan , Kaczmerek-Majer Katarzyna , Rzeźniczak Janusz , Słomczyński Marek , Wichrowski Filip , Hiczkiewicz Dariusz , Musielak Bogdan , Grydz Łukasz , Hiczkiewicz Jarosław , Burchardt Paweł 
Published: May 2023

Abstract
Late recurrence of atrial fibrillation (LRAF) during the first year after catheter ablation is a common and significant clinical problem. Our study aimed to create a machine-learning model for predicting 1-year arrhythmic recurrence after catheter ablation. The study comprised 201 consecutive patients (age: 61.8±8.1; women 36%) with paroxysmal, persistent, and long-standing persistent atrial fibrillation (AF) who underwent cryoballoon (61%) and radiofrequency ablation (39%). Five different supervised machine-learning models (decision tree, logistic regression, random forest, XGBoost, support vector machines) were developed for predicting 1-year AF recurrence after catheter ablation. Next, SHapley Additive exPlanations (SHAP) were derived to explain the predictions using 82 parameters from clinical, laboratory, and procedural variables collected from each patient. The models were trained and validated using stratified 5-fold cross-validation, and feature selection was performed with permutation importance. The XGBoost model with 12 variables showed the best performance on the testing cohort, with the highest AUC of 0.75 [95% confidence interval 0.7395, 0.7653]. The machine-learned model, based on the easily available 12 clinical and laboratory data, predicted the late recurrence of AF up to 1 year after catheter ablation with good performance, which may provide a valuable tool in clinical practice for better patient selection and personalized atrial fibrillation strategy after the procedure.
Childbirth self-efficacy among pregnant women attending antenatal care in public health facilities in Arbaminch town, Southern Ethiopia 2023: a cross-sectional study
Authors: Simon Tesfahun , Fikadu Kassahun , Afework Bezawit , Alemu Habtamu , Kussia Begetayinoral 
Published: May 2023

Abstract
Background: Childbirth self-efficacy is pregnant women's perception of their ability to cope with labor stress. Low childbirth self-efficacy is linked to pain intolerance and poor labor progression, which increase the possibility of operative deliveries. However, Ethiopia has limited data. So, the aim of this study was to assess childbirth self-efficacy and its factors among pregnant women attending antenatal care in public health facilities in Arbaminch town, Southern Ethiopia, in 2023.
Methods: An institution-based cross-sectional study was carried out among 422 women from January 1 and January 30, 2023. A systematic random sampling technique was employed. Data were collected through face-to-face interviews using a structured and pre-tested questionnaire. Modified short form childbirth self-efficacy inventory was used to score self-efficacy. The Statistical Package for Social Sciences, version 27, was used for data management and analysis. Descriptive statistics were calculated for each variable, and logistic model was used. Statistical significance was determined at a p-value of less than 0.05 and 95% confidence level.
Results: A total of 416 pregnant women participated in the study. Two hundred twenty eight (54.8%) of the pregnant women had a low childbirth self-efficacy. Age group in ≤24 years (AOR=3.80,95% CI:1.82-8), being primigravida(AOR=1.51,95% CI:1.10-2.86), unplanned pregnancy(AOR=1.67, 95% CI:1.02-2.70), poor social support(AOR=2.17,95%CI:1.09-4.30), having anxiety(AOR=1.30, 95% CI:1.10-3.64), having poor knowledge of childbirth (AOR=2.21, 95% CI:2.09-5.39), and sever fear of childbirth(AOR=6.40,95% CI:2.60-9.80) were statistically significant with low childbirth self-efficacy. Conclusions: The magnitude of low childbirth self-efficacy was high in the study area. Being primigravida, unplanned pregnancy, age ≤24 year, sever fear of childbirth, anxiety, never support from husband, poor social support, and poor knowledge were significantly associated to low childbirth self-efficacy. Therefore, giving special attention to these factors during antenatal care would be important.
The effect of health-related hardiness education in patients with neuromyelitis optica spectrum disorders
Authors: XU Yafang , YUAN Li , ZHAO Yan , MA Yue , QUAN Chao , CAO Yanpei 
Published: May 2023

AbstractBackgroundNeuromyelitis optica spectrum disorder (NMOSD) is a chronic inflammatory demyelinating disease of the central nervous system with both a long course and high disability rate. It can cause different degrees of neurological impairment, resulting in the increased perception of stress in the patient. Health-related hardiness is psychological defense against stressors in cases of illness. The study was to investigate the role of health-related hardiness between disability and perceived stress in NMOSD patients and conduct health-related hardiness education for NMOSD patients to observe changes in health-related hardiness and perceived stress.MethodsThe study investigated disability status, health-related hardiness, and perceived stress in NMOSD patients. The mediating effect of health-related hardiness between disability status and perceived stress was verified. Additionally, health-related hardiness education was used as an intervention to improve the health-related hardiess. The Extended Disability Status Score (EDSS), Health-Related Hardiness Scale (HRHS), and Perceived Stress Scale (PSS) were used to assess patient disability status, health-related hardiness, and perceived stress.Results128 patients were completed the investigation of HRHS, EDSS and PSS. 69 patients were enrolled in the health-related hardiness education study. NMOSD patients exhibited high levels of perceived stress. Health-related hardiness played a mediating role between disability and perceived stress, with mediating effect accounting for 12.7% of the total effect. After patients received health-related hardiness education, the score of health-related hardiness were significantly elevated and perceived stress scores were significantly lower.ConclusionHealth-related hardiness had a partial mediating effect between disability and perceived stress in NMOSD patients. Health-related hardiness education could effectively increase health-related hardiness, as well reducing perceived stress caused by NMOSD.
Ensuring the Accuracy of FE-based Nonlinear Dynamic Reduced-order Models
Authors: Xiao Xiao , Hill Thomas L , Neild Simon A 
Published: May 2023

Abstract
Numerous powerful methods exist for developing Reduced-order Models (ROMs) using Finite Element (FE) models. Ensuring the accuracy of these ROMs is essential; however, the validation using dynamic responses is expensive. In this work, we propose a method to ensure the accuracy of ROMs without extra dynamic FE simulations. It has been shown that the well-established Implicit Condensation and Expansion (ICE) method can produce an accurate ROM when the FE model's static behaviours are captured accurately. However, this is achieved via a fitting procedure, which may be sensitive to the selection of load cases and ROM's order, especially in the multi-mode case. To alleviate this difficulty, we define an error metric that can evaluate the ROM's fitting error efficiently within the displacement range, specified by a given energy level. Based on the fitting result, the proposed method provides a strategy to enrich the static dataset, i.e. additional load cases are found until the ROM's accuracy reaches the required level. Extending this to the higher-order and multi-mode cases, some extra constraints are incorporated into the standard fitting procedure to make the proposed method more robust. A clamped-clamped beam is utilised to validate the proposed method, and the results show that the method can robustly ensure the accuracy of the static fitting of ROMs.
Breast cancer survival and incidence of second primary cancers after 30 years in a randomized study of two versus five years of adjuvant tamoxifen therapy
Authors: Nordenskjöld Anna , Fohlin Helena , Rosell Johan , Bengtsson Nils-Olof , Fornander Tommy , Hatschek Thomas , Lindman Henrik , Malmström Per , Rydén Lisa , Wallgren Arne , Stål Olle , Nordenskjöld Bo 
Published: May 2023

Abstract

Background:
Tamoxifen is an established treatment for breast cancer, but its long-term effects on survival and on secondary cancers are not fully evaluated.
Material and methods:
We studied 30 years outcome of 4124 postmenopausal patients who were randomized to receive (totally) two or five years of adjuvant tamoxifen.
Results:
After 5 years of follow-up, when tamoxifen treatment was finished in both groups, until 15 years of follow-up, overall mortality (HR 0.80, 95% CI 0.72 – 0.90, p< 0.001), breast cancer mortality for all patients (HR 0.80, 95% CI 0.68 – 0.94, p= 0.006) and breast cancer mortality for patients with estrogen receptor positive disease (HR 0.67, 95% CI 0.55 – 0.83, p< 0.001) were significantly reduced in the five-year group as compared to the two-year group. After 15 years, the difference remained but did not further increase.
In the five-year group, the incidence of contralateral breast cancer was gradually reduced during the entire period of observation. The incidence of lung cancer was also reduced in the five-year group. In contrast there was an increased endometrial cancer incidence in the five-year group and for those receiving 40 mg of tamoxifen this incidence was further increased.
Conclusion:
Three more years of tamoxifen therapy reduced the risk of breast cancer mortality. The difference was established during the first 15 years after randomization. Moreover, the incidence of contralateral breast cancer gradually decreased for 30 years. The incidence of lung cancer was reduced in the five-year group. In contrast the incidence of endometrial cancer was increased.
Identifying potential compounds from Bacopa monnieri (brahmi) against Coxsackievirus A16 RdRp targeting HFM disease (tomato flu)
Authors: Punia Parveen , Prajapati Arun , Maitra Priyasha , Mishra Avinash 
Published: May 2023

Abstract
The most promising drug target to treat hand, foot, and mouth disease (HFMD) caused by coxsackievirus (CVA16) is RNA-dependent RNA polymerase (RdRp). This study offered an in-silico pipeline to identify possible RdRp inhibitors against CVA16 RdRp. Here, 91 natural compounds derived from Bacopa monnieri (brahmi) were virtually screened against the RdRp of CVA16. Bacobitacin D, a hit screened in this study, exhibited eight hydrogen bonds with RdRp targeting catalytic site residues (Asp238 and Asp329). Later, the molecular dynamics (MD) simulation and MM/GBSA binding free energy calculations were performed with the top three hits selected on the exhaustive docking score (≤ -9.55 kcal/mole). Bacobitacin D showed the minimum fluctuation (< RMSD > = 0.75 nm, standard deviation = 0.02) over the 100 ns MD simulation time. However, the ΔGTOTAL binding free energy of Bacopaside IV was the lowest with − 23.70 kcal/mole while Bacobitacin D showed comparable ΔGTOTAL with − 19.14 kcal/mole. Later, the middle structures of the most populated cluster obtained from MD simulation were studied for the interaction. Bacobitacin D showed direct interaction with the catalytic residues (Asp238 and Ser289). This study proposed Bacobitacin D as active inhibitor against RdRp of CVA16 that need to be validated in an experiment to ascertain its inhibitory action.
The Effect of Modifying the Sitting and Getting up Method on Pain Intensity in Patients with Pes anserine tendinitis bursitis: A Randomized Clinical Trial Study
Authors: Farsad Faraneh , Moghimi Jamileh , Mirmohammadkhani Majid , Gholami Emad , Moazeni Marjan 
Published: May 2023

Abstract
Background: The aim of this study was to determine the effect of modifying the sitting and getting up method on pain intensity in patients with Pes anserine tendinitis bursitis (PATB).
Methods: This randomized clinical trial study was conducted on 60 patients with PATB who referred to the rheumatology clinic of Semnan city (Iran) in 2020. The sampling method was convenience and eligible patients divided into two groups using a random number table (intervention group, n=30; control group, n=30). First, both groups were advised to lose weight and not to sit on two knees and cross-legged and strengthen the quadriceps muscle by lying on the flat surface for 3 seconds, repeating 30 times and 3 times a day. Then, the rheumatologist taught the intervention group to modify the sitting and getting up method in such a way that the leg is placed in a position where the tibia is in a neutral position and does not rotate outward. However, for the control group, only periodic examinations were performed. Finally, the severity of the knee pain based on visual analog scale (VAS) was measured 8 weeks after intervention for two groups. The data were analyzed using SPSS 24 software and P-Value <0.05 was considered as a significant level.
Results: There were no significant statistical difference between the two groups in terms of baseline variables (age, BMI, pain intensity, duration of osteoarthritis and duration of Pes anserine bursitis) before intervention (P-Value>0.05). However, Repeated Measure ANOVA test showed the mean of pain intensity in the intervention group is lower than the control group after intervention (P-Value<0.001).
Conclusions: This study suggests that modifying the sitting and getting up method can reduce pain intensity in patients with PATB. However, studies with a larger sample size are recommended.
Synthesis, solvatochromism and estimation of ground and excited state dipole moments of silylated benzothiazole dyes
Authors: Paczkowski Ingrid Maliszewski , Pluczinski Lidiane , Campo Leandra Franciscato 
Published: May 2023

Abstract
Dyes derived from benzothiazoles are an important class of heterocycles that have remarkable photophysical properties. New photoluminescent 2-phenylbenzothiazole derivatives containing different functional groups were synthesized in high yields and used for the synthesis of silylated derivatives. New photoactive structures were fully characterized and their photophysical properties were investigated. The absorption and fluorescence spectra of benzothiazoles in a series of organic solvents were evaluated. The results showed that benzothiazoles are strongly fluorescent showing absorption in the UV region and emission in the blue region with moderate quantum yields and high Stokes shift. The solvatochromism of benzothiazoles was investigated by Lippert and ET(30) Dimroth-Reichardt empirical solvent polarity scales for organic solvents. The dipole moments obtained by Bakshiev and Kawaski-Chamma-Viallet equations revealed that the excited states are more polar than the ground states.
Comparison of the dried properties of Ganoderma lucidum produced by the convective dryer and infrared dryer
Authors: Naseri Maryam , Movagharnejad Kamyar , Nanvakenari Sara 
Published: May 2023

Abstract
The Ganoderma Lucidum is known as a promising medicine that contains a high amount of antioxidants and calcium. The selection of appropriate drying process methods in food science has a chief role to reach the best final characteristics. This study was aimed to investigate the effects of air velocity and temperature in the convective dryer, sample distance, and infrared power in infrared dryers on the drying kinetics and quality of Ganoderma lucidum slices. In addition, Response Surface Methodology based on central composition design was used to optimize and analyze drying conditions. The ranges of temperature and air velocity were 40 to 60 C° and 0.5 to 1.5 m/s, respectively in the convective drying process while the range of distance and infrared power was 4 to 16 cm and 500 to 1500 W, respectively in the infrared drying process. It is worth mentioning that antioxidant and calcium contents were greatly enhanced during the drying procedures. Moreover, the values of the total color difference ranged between 8.21 and 19.66 for convective dryer and 8.14 and 28.85 for infrared dryer. A kinetic study indicated that dried samples by infrared dryer could rapidly reach equilibrium moisture content due to exposure to IR radiation. Consequently, the results indicated that the infrared dryer has better performance than the convective dryer regarding drying time, energy consumption, and amount of calcium and antioxidant.
An automatic control of robotic polishing for a compound surface composed of a plane and curved parts
Authors: Mahamed Hosham , Duan Jinjun , Dai Zhendong 
Published: May 2023

Abstract
The presented paper proposes a robotic polishing method for compound surface composed of plane and curved parts to increase quality, reducing cost, time and effort compared to manual polishing. The polishing approach is adopted based on the smooth trajectory planning, constant force algorithm, and modeling the removal profile depth. In order to generate a smooth polishing path that helps in stability and accuracy of motion during the polishing operation, a cubic B-spline interpolation curve with the harmonic model approach and Squad method were used. An online stiffness and reverse damping force (OSRDF) impedance controller supported by gravity compensation algorithm is used to to achieving a constant polishing force. Consequently, to evaluate the quality of a polishing results, the removal depth model is determined for plane and curved surfaces before and after polishing. The experimental studies were conducted to polish the manufactured box composed of resin material using the UR robot manipulator for validating the proposed method. The results of experiments proved the constancy of polishing force thanks to the OSRDF impedance controller with a small fluctuation directly proportional to the value of applied force. It also showed accurate equality of removal depth at the applied force of 20 N. The overall results explained that a presented polishing approach has a good capability to polish a compound surface with shiny appearance after painting.