bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Traumatic Disorder on Families of United Nation Soldiers Deployed on Peace Keeping Missions
Authors: Chi Nevile 
Published: March 2023

Purpose: The study sought to investigate the use of impact of traumatic disorder on families of United Nation soldiers deployed on peace keeping missions.
Materials and Methods: The study adopted a desktop methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.
Findings: The findings show that wives of military personnel on peacekeeping mission are beleaguered by a number of psychosocial problems among which are loneliness, fear that the husbands might lose their lives during the mission, children missing their fathers and lack of guidance and counseling on how coping could be achieved.
Unique Contribution to Theory, Practice and Policy: The quantity of life theory was very instrumental in this study, future studies anchored on different context could benefit from the theory. The study recommended that, there is need to pay increased attention to military families affected by combat deployment to the current conflicts. Transitions such as those engendered by the deployment cycle offer prime opportunities to strengthen already present skills and introduce new strategies. Policy maker’s needs to provide a framework for understanding and supporting military families affected by deployment, and adapt, a new implementation of family care being developed specifically for military families that empowers parents to be their children’s best teachers.
The Use of Sanction by Super Powers Countries and Their Impact on Other Countries
Authors: Trump Bobby 
Published: March 2023

Purpose: The study sought to investigate the use of sanction by super powers countries and their impact on other countries.
Methodology: The study adopted a desktop methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.
Findings: The study concluded that sanctions are one of the most important and most attractive ways for deference of the targeted country. Security Council's sanctions that are issued on the basis of Article 41 of the Charter are the proof of this claim. But bilateral and multilateral sanctions outside the UN framework have many applications.
Unique Contribution to Theory, Practice and Policy: The study recommended that, U.S. and Russia must recognize the lasting quality of international politics and create a basis of understanding as such by acknowledging the legitimate interests and concerns of the others. The study also recommended that countries could consider establishing the authority and effective procedures or mechanisms to propose persons and entities to the Security Council for designation in accordance with relevant Security Council resolutions which impose targeted financial sanctions in the context of the financing of proliferation of weapons of mass destruction.
Isolation of Genes Encoding for Human Epidermal Growth Factor (hEGF) from Human Blood: In Vitro and In Silico Study
Authors: Maelani Imelda , Suhartono Suhartono , Zulkarnain Zulkarnain 
Published: March 2023

The 6.12 kDa human epidermal growth factor (hEGF) protein is expressed in the body and plays a role in cell proliferation and differentiation. This research aims to isolate the hEGF genes, determine the phylogenetic relationship between organisms based on the hEGF gene, construct the 3D structure of the hEGF protein, and identify the precise binding position between the hEGF protein and the tested Myosin-9. DNA was isolated from blood of healthy individuals followed by amplification using specified primers. DNA sequencing was utilized to identify the amplification results before generating the phylogenetic trees. The retrieved sequences were then modeled using the Swiss model and docking proteins in silico. In three samples, DNA was successfully amplified to 700 bp and the phylogenetic analysis revealed that the three hEGF gene samples belonged to the same clades. With a 30 % identity seq, aligned result sequences modeled using the Swiss model created proteins which were not homologous. The outcomes of this modeling were compared to the hEGF protein from the database, which had a sequence identity of greater than 90 %. The i-RMSD value of the target protein (5.4 +/- 0.4), the Van der Waals energy (-29.3 +/- 1.7), and the Z-score were determined by simulation (-1.7). These results indicate a potential interaction between the isolated EGF protein and the myosin-9 tested.
HIGHLIGHTS

Human Epidermal Growth Factor (hEGF) protein is a potential protein expressed in the body and plays a role in cell proliferation and differentiation
Isolation of the EGF gene through human blood can be carried out to get data on protein size, phylogenetic analysis, and protein structure
The results of in vitro study were modeled in silico to obtain the three-dimensional structure as well as intermolecular interactions of the protein
Information beginning this study is used in follow-up research to predict EGF communications with other molecules

GRAPHICAL ABSTRACT
Tectonic Implication of the Permo-Triassic Khao Yai Mafic Volcanic Rocks in Nakhon Nayok Province, Thailand: Evidence from Geochemistry and Rare Earth Elements (REEs)
Authors: Jundee Patcharin Kosuwan , Panjasawatwong Yuenyong , Limtrakun Phisit , Salyapongse Sirot 
Published: March 2023

The Permo-Triassic Khao Yai Volcanics in Nakhon Nayok Province, Thailand, is a part of the Loei-Phetchabun-Nakhon Nayok Volcanic Belt. The purpose of this study is to clarify the geochemistry and REEs characteristic of Khao Yai Volcanics that is useful for identifying the paleo-environment or tectonic setting eruption in this area. The least-altered, mafic volcanic rocks from the Permo-Triassic Khao Yai volcanics, are seriate-textured to porphyritic, with variable amounts of phenocrysts/microphenocrysts. The mineral compositions include plagioclase, clinopyroxene, orthopyroxene, olivine, minor Fe-Ti oxide mineral, amphibole, apatite, biotite/phlogopite, monazite/zircon, glassy, and quartz. The geochemical characteristic of the Khao Yai Volcanics informed that the rocks had the same parental magma with different degrees of crystal fractionation. Most of the mafic volcanic rocks are subalkalic andesite on the basis of their Zr/TiO2 and Nb/Y ratios and calc-alkalic on diagrams Ti-Zr, Ti-Zr-Y, Hf-Th-Ta and Y-La-Nb. The least-altered mafic volcanic rocks have (La/Sm)cn and (Sm/Yb)cn ranging from 2.41 to 2.71 and 1.86 to 2.22, respectively. The studied calc-alkalic andesite are analogous to the Quaternary calc-alkalic dacite and andesite from Maca Volcano, Patagonian Andes and the Middle Eocene andesite from Shimokoh cauldron, SW Japan in terms of chondrite-normalized REEs and N-MORB normalized patterns. Accordingly, the studied Khao Yai volcanics have been developed in an active continental margin, formed by eastward underthrusting Paleo-Tethys, the leading edge of Shan-Thai, beneath Indochina in the Late Permian to Early Triassic.
HIGHLIGHTS

New tectonic model of the Permo-Triassic Khao Yai mafic volcanic rocks in Nakhon Nayok Province, Thailand
The geochemistry and rare earth elements (REEs) analysis by XRF and ICP-MS
The REEs analog to modern volcanic rock
The classification of pre-Jurassic volcanic belt in Thailand

GRAPHICAL ABSTRACT
EFFECT OF MONETARY POLICY ON SELECTED MACROECONOMIC VARIABLES IN NIGERIAN
Authors: Mary Nkechinyere Onwudiegwu  , Nonso John Okoye  , Hillary Chijindu Ezeaku  , Nnamdi Lawrence Okeke  
Published: March 2023

This study analyzed the effects of monetary policy on selected macroeconomic variables in Nigeria from 1986 to 2019. The relationship between monetary policy and macroeconomic variables in Nigeria has been a contentious issue due to inconsistent implementation and empirical findings. The study specifically evaluated the impact of monetary policy rate, cash reserve ratio, liquidity ratio, and money supply, as independent variables, on inflation and employment rate, the dependent variables. The study design was ex-post facto and utilized the Error Correction Mechanism (ECM) Model for estimation. The analysis revealed a negative and insignificant relationship between the monetary policy instruments and the selected macroeconomic variables. The conclusion was that the Central Bank of Nigeria's monetary policy adjustments have not effectively improved macroeconomic conditions in Nigeria. The study recommended increasing awareness of financial inclusion in rural areas, promoting collaboration between monetary and fiscal policy managers, and directing efforts towards enhancing the development of both the money and capital markets.
Keywords: Monetary Policy, Macroeconomic Variables, Nigeria.
Prognostic Impact of Modified Glasgow Prognostic Score in Patients with Heart Failure with Mildly Reduced Ejection Fraction
Authors: Bezgin Tahir , Çelik Aziz İnan , Karagöz Ali , Baytuğan Nart Zafer , Çağdaş Metin , Karakoyun Süleyman , Kaymaz Cihangir 
Published: March 2023

Introduction: Inflammation and malnutrition may trigger heart failure development and progression (HF). However, the relationship of the modified Glasgow prognostic score (mGPS), which is derived from C-reactive protein and albumin with mildly reduced ejection fraction HF (HFmrEF), is not well-known. We aimed to determine whether the modified Glasgow prognostic score (mGPS) is helpful for the prediction of all-cause mortality in patients with HFmrEF.
Patients and Methods: Patients with HFmrEF admitted to our outpatient clinic between January 2016 and January 2020 were enrolled. All-cause mortality was defined as the primary endpoint. The mGPS was calculated and, its association with overall survival was determined.
Results: Data were analyzed for 259 patients. The mGPS≤ 1 in 172 (66%), and 2 in 87 (34%) patients, respectively. Higher mGPS was related to worse results of routine biomarkers associated with prognosis, especially NT-proBNP [777 (112-4564) pg/mL vs. 350 (65-3521) pg/mL, respectively, p< 0.0001)]. In multivariable Cox model, NT-proBNP [1.83 (1.32-2.55), p< 0.0001], mGPS 2 vs. ≤1 [2.43 (1.2-4.93), p= 0.013], and coronary artery disease (CAD) [3.15 (1.46-6.82), p= 0.003] were found to be independently associated with all-cause mortality.
Conclusion: The immune-nutritional score mGPS predicts mortality during long-term follow-up of patients with HFmrEF. The mGPS might be used for risk status assessment of HFmrEF.
Sacubitril/Valsartan Treatment in Heart Failure Increases The Left Ventricular Ejection Fraction: A Bayesian Analysis
Authors: Birdal Oğuzhan , Saygı Mehmet , Demir Gündoğmuş Pınar , Aksakal Emrah , Özkalaycı Flora 
Published: March 2023

Introduction: Heart failure is an important leading cause of mortality and morbidity despite optimal medical treatment and device therapy. Sacubitril/valsartan, a first-generation drug, was approved to use heart failure treatment recently. There are limited studies on the relationship between sacubitril/valsartan and left ventricular contraction. In our study, we aimed to evaluate the changes in left ventricular ejection fraction (LVEF) after sacubitril/valsartan treatment.
Patients and Methods: Fifty-two patients with heart failure and reduced ejection fraction (HFrEF) were enrolled in this study. The baseline demographic, clinical, and echocardiographic characteristics of 52 patients were compared using the Bayesian method.
Results: Fifty-two patients with heart failure and reduced ejection fraction (HFrEF) were included in the final analysis (66.2 ± 9.3 years, 69.2% male). Sacubitril/valsartan initial dose was low in 44.2% of patients, and intermediate in 55.8%. In the low initial dose population, the increase in absolute LVEF was 3.87 (95% HDI 1.53-6.20) and in the intermediate initial dose population, the increase in absolute LVEF was 5.89 (95% HDI 4.18-7.61). In the female population, the increase in absolute LVEF was 5.56 (95% HDI 3.49-7.63) and in the male population 4.75 (95% HDI 2.91-6.58) respectively.
Conclusion: In this study, we demonstrated that sacubitril/valsartan is associated with increased LVEF regardless of baseline clinical characteristics.
Adaptation to Turkish of the Self-Care of Heart Failure Index: A Validity and Reliability Study
Authors: Afşar Füsun , Kayalı Serpil , Kesgin Vildan , Akgün Taylan , Yılmaz Habip 
Published: March 2023

Introduction: Heart failure is a chronic and progressive disease with increasing prevalence and incidence worldwide, despite advances in science and technology, and it necessitates long-term follow-up, treatment, and care. Self-care in heart failure is one of the fundamental elements of quality of life and disability-free living. The aim of this study was to assess the validity and reliability of the Turkish version of the Self-Care of Heart Failure Index v.2 (SCHFI).
Patients and Methods: The study sample included 233 patients who presented with a diagnosis of heart failure and volunteered to participate in the research at a training and research hospital. The data were collected using a personal information form and the SCHFI. The SCHFI was translated into Turkish, and the internal consistency coefficient and the item-total points reliability coefficient were analyzed for the reliability study. To determine structure validity, Explanatory Factor Analysis and Confirmatory Factor Analysis were performed.
Results: The adaptation of the SCHFI to Turkish culture was found to have high structure validity and internal consistency in the reliability and validity studies.
Conclusion: We concluded that the Self-Care of Heart Failure Index can be used as a unidimensional scale.
Prevalence of Karapada daha-suptata in Madhumeha with reference to diabetic peripheral neuropathy in type 2 diabetes mellitus patients.
Authors: Bajagain Sarita 
Published: March 2023

Background: Diabetes mellitus is a major health issue in today's world. Main threat is not the disease itself but its complications like nephropathy, retinopathy and neuropathy etc. Diabetic peripheral neurropathy is the leading cause of foot ulcers, their complications like limb amputation and cost associated with it. Madhumeha which has been described as 'Maharogas' i.e. difficult to treat disease has many similarities with Diabetes mellitus can be understood and studied as same disease. Ayurveda has mentioned the causes, pathophysiology and symptoms of Diabetic Peripheral Neuropathy as 'karapada daha -suptata' in purvarupa lakshanas and upadrava lakshanas but inscattered form. It needs depth study to understand the concept of Karapada daha- suptata (DPN).
Objective: To study prevalence of Karapada daha-suptata (Diabetic peripheral neuropathy) and the relation of Karapada daha- suptata (DPN) with age, gender, duration of disease Madhumeha, blood sugar level, alcohol and smoking habit etc in Madhumeha patients.
Method :A cross sectional study was carried out in Tribhuvan University Ayurveda Teaching Hospital,. Madhumeha patients (Type 2 diabetes mellitus) patients were recruited for the study. MNSI (Michigan Neuropathy Screening Instrument) was used to diagnose Karapada daha- suptata (Diabetic peripheral neuropathy).
Result: Among 100 patients 31% patient had Karapada daha- suptata (DPN). Our study showed that the prevalence of Karapada daha-suptata(DPN) increased with increasing age of the study population. Similarly prevalence of Karapada daha -suptata in patients with disease duration of Madhumeha (DM2) for more than 5 years was 61.29% where as patients having Diabetes for less than 5 year was 38.71%. Prevalence of Karapada daha-suptata (DPN) was very high (43.13%) among uncontrolled fasting blood sugar level (>126mg/dl) and (47.5%) among uncontrolled post prandial blood sugar level (>200mg/dl). In this study mean Fasting blood sugar level was 177.0323 mg/dl in the patients with Karapada daha-suptata(DPN) and mean post prandial blood sugar level in patients with diabetic peripheral neuropathy was 239.1613mg/dl.
Conclusion: Our study showed Karapada daha-suptata/DPN is highly prevalent and increasing as the duration of disease Madhumeha increses but its not uncommon in newly disagnosed disease too. This study showed significant relation of Karapada daha suptata with disease duration of Madhumeha, level of blood sugar, and increasing age of the patients.Study showed no significant differences in the prevalence of Kara pada daha- suptata in male and female patients and with the smoking habit of the patients.
Scientific Overlook of Shodhan Concept in Ayurvedic Pharmaceutics: Metals and minerals
Authors: Yadav Kapil Deo 
Published: March 2023

Shodhan, unique concept of purification & potentiation in Ayurvedic pharmaceutics, specially mentioned for metals and minerals which have been indicated in range of disorders from common (fever etc.) to serious (cancer etc.) disorders. Shodhan of metals and minerals is extremely depending up on its physico-chemical properties. The metals & minerals having melting point more than 5000C (Swarna-Gold, Lauha-Iron, Tamra-Copper etc) subjected to Shodhan by Nirvapa (Heating and dipping into liquid medium) whereas Dhalana (Heating, melting and dipping into liquid medium) process is applied to the substance having melting point in range of 100 to 500 0C (Naga-Lead, Vanga-Tin, Yasad-Zinc etc.). Furthermore, substances of organic origin like praval (coral), mukta (pearl), shankha (conch shell) etc. and metals/ mineral having melting point less than 100 0C like parad (mercury) is mainly subjected to shodhan either by swedan (Boiling or Fomentation with liquid) or bhavana (Trituration with small quantity of liquid) process.
Study On Mental Health Literacy Among Ayurveda Undergraduate Students In Nepal
Authors: Khayamali Dr. Renu , Thagunna Dr. Narendra Singh , Khayamali Bishnu Prasad 
Published: March 2023

Background: Mental health literacy is knowledge and beliefs about mental disorders which aid their recognition, management or prevention. Mental health is an integral part of health of an individual. For an individual to be called healthy he should be physically as well as mentally healthy. In Ayurveda, the mental health has been emphasized and its significance has been addressed very clearly.
Aim and Objectives: The aim of the present study is to access the knowledge regarding mental health in Ayurveda under-graduate students in Nepal.
Methods: A cross-sectional observational questionnaire on ‘Mental health knowledge Schedule’ (MAKS) was distributed to 200 Ayurveda undergraduate students. Convenient method of sampling was used for the study.
Results and Conclusion: The study revealed that the Ayurveda students in Nepal have high mental health literacy with mean score 76.32, whereas while comparing between the group, the AHA (Ayurveda Health Assistant), First and Second professional students have medium mental health literacy with mean score 74.22, 74.67 and 74.41 respectively and the third professional and intern have high mental health literacy with mean score 79.59 and 81.29 respectively. The intern have highest mental health literacy, which indicate that the knowledge regarding mental health increased with the increase in their educational level.
The study can prove as a helpful tool in future works and further assessment about knowledge, skill, attitude and behavior towards mental health.
An Overview of Clinical Applications of Virtual and Augmented Reality
Authors: Farrell Keeley , MacDougall Danielle 
Published: March 2023

This Horizon Scan summarizes the available information regarding virtual reality (VR) and augmented reality (AR) interventions for various clinical applications. While the technologies are not new, the use of VR and AR as clinical interventions in health care is still emerging in Canadian health care systems.
VR interventions have been studied in various clinical applications, including acute and chronic pain, stroke, traumatic brain injury, cerebral palsy, Parkinson disease, autism spectrum disorder, anxiety and depression, mental health in older adults, and attention-deficit/hyperactivity disorder (ADHD). Limited information on AR interventions was identified in this Horizon Scan.
There is a wide range of VR and AR hardware and software available that varies in cost and complexity. Much of this hardware and software is commercially available; however, some have been developed specifically for clinical use.
There are several VR interventions for various clinical indications cleared by the FDA and available in the US.
Many factors should be taken into account when considering implementing a VR or AR intervention, including those related to safety, privacy, and access. It will be essential to ensure equitable access to VR and AR interventions so that their introduction does not exacerbate health inequities.
Amivantamab (Rybrevant)
Authors: CADTH  
Published: March 2023

CADTH recommends that Rybrevant be reimbursed by public drug plans for the treatment of locally advanced or metastatic non–small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) exon 20 insertion mutations whose disease has progressed on or after platinum-based chemotherapy if certain conditions are met.
Rybrevant should only be covered to treat patients who have EGFR exon 20 insertion mutation–positive NSCLC that has spread to other parts of the body or cannot be removed by surgery, and who have already received treatment with a platinum-based chemotherapy. Patients receiving Rybrevant should be in relatively good health.
Rybrevant should only be reimbursed when it is used after platinum-based chemotherapy and if its cost is reduced. It should not be reimbursed if it is given in combination with other anticancer drugs. Rybrevant must be prescribed by specialists with experience managing NSCLC.