bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-related white matter differences in children with neurofibromatosis type 1 compared to controls
Authors: Bruckert L. , Travis K. E. , Tam L. T. , Yeom K. W. , Campen C. J. 
Published: September 2023

AbstractNeurofibromatosis type 1 (NF1) is a common genetic condition in which 30-70% of children experience learning challenges including deficits in attention, executive function, and working memory. White matter pathways have been implicated in these cognitive functions; yet, they have not been well characterized in NF1. In this retrospective cohort study, we used diffusion MRI tractography to examine the microstructural properties of major white matter pathways in 20 children with NF1 aged 1 year to 18 years relative to 20 age-and sex-matched controls. An automated approach was used to identify and extract mean diffusivity (MD) and fractional anisotropy (FA) of eight cerebral white matter pathways bilaterally and the anterior and posterior part of the corpus callosum. Compared to controls, children with NF1 had significantly increased MD and significantly decreased FA in multiple white matter pathways including the anterior thalamic radiation, cingulate, uncinate fasciculus, inferior fronto-occipital fasciculus, arcuate fasciculus, and corticospinal tract. Differences in MD and FA remained significant after controlling for intracranial volume. In addition, MD and FA differences between children with NF1 and controls were greater at younger than older ages. These findings have implications for understanding the etiology of the neurocognitive deficits seen in many children with NF1.
Knowledge on female hygiene and its associated diseases: a mini review
Authors: Girigoswami Koyeli , Girigoswami Agnishwar , Harini A. , Thanujashree J. 
Published: September 2023

PurposeMenstruation is a part of the female reproductive cycle that begins with adolescence. Menstruation is a natural change; it relates to several malpractices and misconceptions that may contribute to adverse health outcomes.Design/methodology/approachThe authors have searched relevant papers using Google Scholar and PubMed to write this mini review.FindingsDuring menstruation, poor hygiene maintenance can cause serious illness, which includes the urinary tract and reproductive tract infection. Menstruation management is a hygienic system, and it is essential for females because poor hygiene maintenance during menstruation can cause some infections and numerous sexually transmitted diseases. There are a few nanotechnology-based products that have come into the market to offer some relief to females during their periods.Originality/value This mini review will help researchers to design innovative female hygiene products that can relieve the discomfort caused to women during their reproductive age.
Losing faith in paid employment: an extension of the psychological contract breach model as a predictor of self-employment
Authors: Abord de Chatillon Emmanuel , Bornard Fabienne , Ottmann Jean-Yves , Felio Cindy 
Published: September 2023

PurposeIt seems that some aspects of employees' experience can lead to their “losing faith in the system of paid employment”. This disillusion can be studied and measured through the theoretical construct of a psychological contract breach experienced by the employee. This exploratory article thus examines whether the conditions of paid employment could lead to a new dimension of psychological contract breaches: a breach with paid employment itself that could drive to self-employment.Design/methodology/approachThe authors use a structural equation modeling on a sample of 403 people who have declared their intention to leave paid employment for self-employment.FindingsThe study's results show that working conditions affect psychological contract breaches in various dimensions. The authors propose a dimension of psychological contract breaches linked to paid employment, which can lead to the choice to leave paid employment and become self-employed. The authors also confirm the importance of working conditions as antecedents of psychological contract breaches.Research limitations/implicationsThe main limitations of this exploratory research are the use of unvalidated scales and a small sample size, with a population that could be better defined. As Murgia et al. (2020) point out, it is not yet clear at the moment whether this category is a special group, equivalent to traditionally distinguished groups of working people. The study's assumptions and these limitations lead us to propose the following avenues for future research.Practical implicationsFor managers and the development of management, the possible relationship between working conditions and psychological contract breaches seems to be very important. In fact, a whole range of best management practices could be developed if this relationship is confirmed. Improving working conditions could thus be a way to repair psychological contracts.Social implicationsThis research field is still quite underdeveloped in comparison to its importance to organizations because the increase in self-employment challenges traditional models and assumptions in human resources management.Originality/valueThis study aims to expand the theoretical frameworks of psychological contracts and breaches. It thus responds to recent calls for research on psychological contracts (Bankins et al., 2020); Moreover, this research suggests, in line with the work of Aubert and de Gaulejac (2018), that there are relationships between poor working conditions and psychological contract breaches. To the authors' knowledge, this approach is missing from international research into psychological contracts, which focuses only on job characteristics and individual determinants (personality traits, etc.).
Impact of augmented reality on operational performance: the mediating role of process innovativeness
Authors: Turkcan Hulya , Imamoglu Salih Zeki , Ince Huseyin 
Published: September 2023

PurposeThe purpose of this paper is to investigate the relationships between augmented reality, process innovativeness and operational performance.Design/methodology/approachThis research is based on a quantitative approach using a questionnaire survey from a total of 117 firms in the automotive sector. The hypothesized relationships are tested using partial least square structural equation modeling (PLS-SEM).FindingsThis study demonstrates that augmented reality is positively associated with process innovativeness, and process innovativeness is positively related to operational performance. Furthermore, it is found that process innovativeness fully mediates the relationship between augmented reality and operational performance.Originality/valueAlthough augmented reality attracts great attention from academics and practitioners, the current literature lacks an empirical investigation on how augmented reality creates value for the business. Addressing this crucial gap, this research is the first attempt to empirically reveal the role of augmented reality in facilitating process innovativeness and also unearthing how augmented reality improves operational performance. Therefore, this study offers novel insights into the role of augmented reality in business and provides theoretical and managerial contributions.
Brand equity determinants and ecologically conscious consumer behavior in ridesharing: serial mediation and moderation analysis
Authors: Singh Anurag , Patel Ashok Kumar , Jaiswal Shefali , Duhan Punita , Singh Vinod Kumar 
Published: September 2023

PurposeThis study focuses on Aaker's Brand Equity Model, to check the effect of brand equity determinants on booking intention (BI) for ridesharing in India. The study also explores the moderation of ecologically conscious consumer behavior (ECCB) on the multiplicative effect of brand awareness (BAw), brand association (BA) and perceived quality (PQ) in influencing the BI.Design/methodology/approachResponses from 393 Indian ridesharing users were collected using judgmental sampling and were analyzed using Hayes Process macro.FindingsThe study found a direct relationship between BAw and BI, BAw and BA, BAw and PQ, BA and PQ, PQ and BI, and BA and BI. Findings revealed mediation of BA in BAw and BI relationship and PQ in BAw and BI relationship. Results revealed that BA and PQ serially mediate BAw and BI relationship. ECCB moderates PQ and BI relationship but not BAw and BI relationship.Research limitations/implicationsSerial mediation and moderated-mediation results draw various theoretical implications for determinants of Aaker's Brand Equity model and ECCB.Practical implicationsThe research has several implications for managers in view of brand equity determinants and ECCB. The study also contributes to policy implications.Originality/valueStudy's novel contributions are mediation, serial mediation between brand equity determinants, and moderation of ECCB between BAw and BI for ridesharing.
Reel critical: using film to teach Indigenous studies in the elementary classroom
Authors: Van Haren Kate , Stebbins Abigail 
Published: September 2023

PurposeFilm has long been an instructional tool in social studies education; however, most research and methods for using film to teach social studies are situated at the secondary level. As such, the purpose of this study was to extend and expand what is known about using film in elementary social studies classrooms. More specifically, this qualitative content analysis study explored how and why elementary pre-service teachers (PSTs) used film clips from Molly of Denali to design critical Indigenous studies lessons. The data offer insight into the possibilities of using film as a strategy to teach anti-oppressive elementary social studies education.Design/methodology/approachThe authors used qualitative content analysis in this study. Data for this study included 17 lesson planning assignments and corresponding written rationales completed by PSTs in an elementary social studies methods course. Data collected as a result of convenience sampling, given both the authors were the instructors of the methods course. To analyze the data, the authors used a multi-step coding process and a combination of inductive and deductive coding.FindingsGrounded in a framework of anti-oppressive and anti-colonial education, PSTs designed elementary social studies lessons that used film clips from Molly of Denali to increase representation, center a counter-narrative and serve as a motivator. PSTs also infused other sources into their lesson plans, thus extending their lessons beyond the film.Originality/valueGiven the lack of research on how film can be used in elementary social studies classrooms, this study fills a void in the literature. Results of this study suggest that similar to the benefits of using film in secondary classrooms, film can be an engaging and motivating source of information for elementary students. Moreover, when used within a critical pedagogical framework like Sabzalian's (2019) critical orientations of Indigenous studies, film can increase representation and teach anti-oppressive counter-narratives in the elementary classroom.
‘Having the dog as part of our family gives us hope’: Experiences of the impact of assistance dogs on the occupational engagement of children with autism and their families
Authors: Agnew Zoe , Callaway Libby , Lalor Aislinn , Peart Annette , Bould Em 
Published: September 2023

AbstractBackgroundAutism is a developmental disorder characterised by changes in social, communication, and behavioural performance. Assistance dogs can support children with autism to engage in everyday occupations. Despite more children being partnered with assistance dogs, there is limited research regarding the impact of assistance dogs on the occupational engagement of children with autism and their families, and further research is needed to fully understand the impact of this type of support within the Australian context.ObjectivesTo explore caregiver‐reported experiences of an assistance dog on the occupational engagement of children with autism and their families.MethodUsing a qualitative approach, semi‐structured interviews were undertaken with six caregivers of seven children with autism, who each had an assistance dog. Interviews ranged from 45 to 60 minutes in duration. Data were transcribed verbatim and thematically analysed. Trustworthiness was maximised through independent recruitment, research team discussions, member checking, and a researcher reflective journal.FindingsThree themes were identified: participation in everyday occupations prior to and after partnering with an assistance dog, increased engagement in everyday occupations, and impact of the assistance dog on the family unit. Assistance dogs were reported to progress children from community ‘isolation’ to ‘freedom’. Participants reported the dog increased children's capacities through positively influencing completion of routines, increasing independence, and improving therapy engagement. Assistance dogs were viewed as supporting the whole family's occupational engagement. Some challenges were identified with the introduction of the assistance dog to the family unit, and with animal maintenance costs and time demands, public access rights, and limited government funding.ConclusionThis research identifies benefits and challenges for children who partner with autism assistance dogs. It provides insights to inform assistance animal referral, assessment, and support of assistance dogs in Australia for children with autism and occupational therapists working with them.
Stabilization and valorization of tomato byproduct: A case study for the bakery industry
Authors: Fernandez‐Pan Idoya , Ibañez Francisco C. , Virseda Paloma , Arozarena Iñigo , Beriain María José 
Published: September 2023

AbstractWorldwide, tomato production is estimated at 180 million tons per year, which generates a byproduct with highly variable characteristics and volumes. According to the principles of the circular economy, a semi‐industrial method for the integral use of the tomato byproduct as an ingredient in the bakery industry is proposed. Using two different dehydration processes (convection or freeze‐drying), a tomato byproduct formed by peels and seeds was stabilized and ground into flours that were used as ingredients in focaccia‐type flatbread elaboration through a wheat flour partial substitution trial (from 0% to 20% w/w). Based on the kinetics of convection drying and remaining lycopene content results, conditioning of the byproduct at 60°C was proposed. The higher the percentage of substitution, the greater the firmness of the flatbread. However, the cutting force was maximum with 15% replacement. The flatbreads with 5%–15% replacement were rated positively according to consumer acceptance studies. Substitution of up to 15% tomato byproduct is suggested for the formulation, as the higher the byproduct flour content, the lower the volume, the higher the firmness, and reddish‐brown tones. Realistically, for the industrial setting, this processing proposal reached the whole food chain, from field to fork.Practical ApplicationBased on the circular economy and considering the whole food chain, a case study is proposed to prove the usefulness of tomato byproduct flour implementation in bakery with consumers’ acceptance. Once the tomato byproduct was dehydrated by convection drying and ground, the flour was used to make focaccia‐type flatbread. Up to 15% of tomato byproduct flour addition was accepted by consumers. Considering the tons of tomato byproducts generated worldwide and the overall bakery possibilities, this case shows industrial steps toward sustainable food production practices.
Allogeneic hematopoietic stem cell transplantation for juvenile myelomonocytic leukemia with intestinal Behçet's disease: A case report
Authors: Liu Chang , Fu Caihong , Guo Xuemei , Rong Liucheng , Li Jian , Fang Yongjun 
Published: September 2023

AbstractBehçet's disease (BD) is a rare condition that is seldom associated with hematological malignancies. In this case report, we present the unique case of a 7‐year‐old girl diagnosed with juvenile myelomonocytic leukemia (JMML) and intestinal BD. The patient received allogeneic hematopoietic stem cell transplantation (allo‐HSCT), which resulted in complete remission of both JMML and BD. Our findings suggest that allo‐HSCT may be a feasible treatment option for JMML patients with coexisting BD, and holds promise for achieving remission of both illnesses. However, further clinical investigations are needed to validate these findings.
Paclitaxel promotes mTOR signaling‐mediated apoptosis in esophageal cancer cells by targeting MUC20
Authors: Li Meng , Feng Zhen , Han Rui , Hu Benchuang , Zhang Renfeng , Wang Hui 
Published: September 2023

AbstractBackgroundThe aim of this study was to analyze the effect of paclitaxel on the apoptosis of esophageal cancer cells in relation to MUC20.MethodsRT‐qPCR analysis, a CCK‐8 assay, western blotting, and flow cytometry were used to analyze the anticancer effects of paclitaxel treatment or OE‐MUC20 in vitro and in vivo.ResultsThe in vitro results showed that paclitaxel significantly induced MUC20 upregulation and that paclitaxel treatment or OE‐MUC20 significantly decreased esophageal cancer cell viability and increased mTOR signaling activation and apoptosis. In addition, PKM2, a key downstream molecule of mTOR signaling, similarly showed significant upregulation after paclitaxel treatment in cells with OE‐MUC20, and its expression was attenuated after treatment with mTOR inhibitors. In a nude mouse model, tumor growth was slow in the OE‐MUC20 group and accelerated after inhibition of mTOR signaling.ConclusionThese data suggest that MUC20 is an important target of paclitaxel in esophageal cancer and promotes apoptosis through activation of mTOR signaling.
Antibiotic use as a risk factor for irritable bowel syndrome: Results from a nationwide, case–control study
Authors: Staller Kyle , Olén Ola , Söderling Jonas , Roelstraete Bjorn , Törnblom Hans , Kuo Braden , Nguyen Long H. , Ludvigsson Jonas F. 
Published: September 2023

SummaryBackgroundThe microbiome plays an important role in the pathophysiology of irritable bowel syndrome (IBS). Antibiotic use can fundamentally alter gut microbial ecology. We examined the association of antibiotic use with IBS in a large population‐based investigation.MethodsA case–control study with prospectively collected data on 29,111 adult patients diagnosed with IBS in Sweden between 2007 and 2016 matched with 135,172 controls. Using a comprehensive histopathology cohort, the Swedish Patient Register, and the Prescribed Drug Register, we identified all consecutive cases of IBS in addition to cumulative antibiotic dispensations accrued until 1 year prior to IBS (exclusionary period) for cases and time of matching for up to five general population controls matched on the basis of age, sex, country and calendar year. Conditional logistic regression estimated multivariable‐adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of IBS.ResultsPatients with IBS (n = 29,111) were more likely than controls (n = 135,172) to have used antibiotics up to 1 year prior to diagnosis (74.9% vs. 57.8%). After multivariable adjustment, this translated to a more than twofold increased odds of IBS (OR 2.21, 95% CI 2.14–2.28) that did not differ according to age, sex, year of IBS diagnosis or IBS subtype. Compared to none, 1–2 (OR 1.67, 95% CI 1.61–1.73) and ≥3 antibiotics dispensations (OR 3.36, 95% CI 3.24–3.49) were associated with increased odds of IBS (p for trend <0.001) regardless of the antibiotic class.ConclusionsPrior antibiotics use was associated with an increased odds of IBS with the highest risk among people with multiple antibiotics dispensations.
Policymaking and the Design Workshop: A New Business Direction
Authors: Kim Chorong , Nam Ki‐Young 
Published: September 2023

By all means, design firms should take advantage of the newfound interest in design within government policymaking circles. However, to ensure success—and avoid giving design a bad name in the wake of failed initiatives—be sure to prepare all the participants beforehand with hands‐on design workshops.Across the globe, design firms are seeing interest from government policymakers who want to incorporate design—and especially codesign—into their work. Yes, it may be a great new line of business, but it will require some stakeholder education.
Optimizing CAR‐T cell therapy in adults with B‐cell acute lymphoblastic leukemia
Authors: Agrawal Vaibhav , Murphy Lindsey , Pourhassan Hoda , Pullarkat Vinod , Aldoss Ibrahim 
Published: September 2023

AbstractChimeric antigen receptor T‐cell (CAR‐T) therapy has demonstrated unprecedented success in the treatment of various hematologic malignancies including relapsed or refractory (R/R) B‐cell acute lymphoblastic leukemia (B‐ALL). Currently, there are two FDA‐approved CD19‐directed CAR‐T cell products for the treatment of adults with R/R B‐ALL. Despite high remission rates following CD19 CAR‐T cell therapy in R/R B‐ALL, remission durability remains limited in most adult patients, with relapse observed frequently in the absence of additional consolidation therapy. Furthermore, the burden of CAR‐T cell toxicity remains significant in adults with R/R B‐ALL and further limits the wide utilization of this effective therapy. In this review, we discuss patient and disease factors that are linked to CAR‐T cell therapy outcomes in R/R B‐ALL and strategies to optimize durability of response to reduce relapse and mitigate toxicity in the adult population. We additionally discuss future approaches being explored to maximize the benefit of CAR‐T in adults with B‐ALL.
The evolution of parasite virulence under targeted culling and harvesting in wildlife and livestock
Authors: O'Neill Xander , White Andy , Boots Mike 
Published: September 2023

AbstractThere is a clear need to understand the effect of human intervention on the evolution of infectious disease. In particular, culling and harvesting of both wildlife and managed livestock populations are carried out in a wide range of management practices, and they have the potential to impact the evolution of a broad range of disease characteristics. Applying eco‐evolutionary theory we show that once culling/harvesting becomes targeted on specific disease classes, the established result that culling selects for higher virulence is only found when sufficient infected individuals are culled. If susceptible or recovered individuals are targeted, selection for lower virulence can occur. An important implication of this result is that when culling to eradicate an infectious disease from a population, while it is optimal to target infected individuals, the consequent evolution can increase the basic reproductive ratio of the infection, , and make parasite eradication more difficult. We show that increases in evolved virulence due to the culling of infected individuals can lead to excess population decline when sustainably harvesting a population. In contrast, culling susceptible or recovered individuals can select for decreased virulence and a reduction in population decline through culling. The implications to the evolution of virulence are typically the same in wildlife populations, that are regulated by the parasite, and livestock populations, that have a constant population size where restocking balances the losses due to mortality. However, the well‐known result that vertical transmission selects for lower virulence and transmission in wildlife populations is less marked in livestock populations for parasites that convey long‐term immunity since restocking can enhance the density of the immune class. Our work emphasizes the importance of understanding the evolutionary consequences of intervention strategies and the different ecological feedbacks that can occur in wildlife and livestock populations.