bluuebunny/crossref_metadata_2025_split huggingface dataset:
Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension
Authors: Jani Vivek , Aslam M. Imran , Fenwick Axel J. , Ma Weikang , Gong Henry , Milburn Gregory , Nissen Devin , Cubero Salazar Ilton M. , Hanselman Olivia , Mukherjee Monica , Halushka Marc K. , Margulies Kenneth B. , Campbell Kenneth S. , Irving Thomas C. , Kass David A. , Hsu Steven 
Published: May 2023

Background:
Right ventricular (RV) contractile dysfunction commonly occurs and worsens outcomes in patients with heart failure with reduced ejection fraction and pulmonary hypertension (HFrEF-PH). However, such dysfunction often goes undetected by standard clinical RV indices, raising concerns that they may not reflect aspects of underlying myocyte dysfunction. We thus sought to characterize RV myocyte contractile depression in HFrEF-PH, identify those components reflected by clinical RV indices, and uncover underlying biophysical mechanisms.

Methods:
Resting, calcium-, and load-dependent mechanics were prospectively studied in permeabilized RV cardiomyocytes isolated from explanted hearts from 23 patients with HFrEF-PH undergoing cardiac transplantation and 9 organ donor controls.

Results:
Unsupervised machine learning using myocyte mechanical data with the highest variance yielded 2 HFrEF-PH subgroups that in turn mapped to patients with decompensated or compensated clinical RV function. This correspondence was driven by reduced calcium-activated isometric tension in decompensated clinical RV function, whereas surprisingly, many other major myocyte contractile measures including peak power and myocyte active stiffness were similarly depressed in both groups. Similar results were obtained when subgroups were first defined by clinical indices, and then myocyte mechanical properties in each group compared. To test the role of thick filament defects, myofibrillar structure was assessed by x-ray diffraction of muscle fibers. This revealed more myosin heads associated with the thick filament backbone in decompensated clinical RV function, but not compensated clinical RV function, as compared with controls. This corresponded to reduced myosin ATP turnover in decompensated clinical RV function myocytes, indicating less myosin in a crossbridge-ready disordered-relaxed (DRX) state. Altering DRX proportion (%DRX) affected peak calcium-activated tension in the patient groups differently, depending on their basal %DRX, highlighting potential roles for precision-guided therapeutics. Last, increasing myocyte preload (sarcomere length) increased %DRX 1.5-fold in controls but only 1.2-fold in both HFrEF-PH groups, revealing a novel mechanism for reduced myocyte active stiffness and by extension Frank-Starling reserve in human heart failure.

Conclusions:
Although there are many RV myocyte contractile deficits in HFrEF-PH, commonly used clinical indices only detect reduced isometric calcium-stimulated force, which is related to deficits in basal and recruitable %DRX myosin. Our results support use of therapies to increase %DRX and enhance length-dependent recruitment of DRX myosin heads in such patients.
Rescue Stenting for Failed Mechanical Thrombectomy in Acute Ischemic Stroke: Systematic Review and Meta‐analysis
Authors: Rodriguez‐Calienes Aaron , Vivanco‐Suarez Juan , Galecio‐Castillo Milagros , Sequeiros Joel M. , Zevallos Cynthia B. , Farooqui Mudassir , Siddiqui Fazeel , Ortega‐Gutierrez Santiago 
Published: May 2023

Background
When mechanical thrombectomy (MT) fails to achieve successful reperfusion, rescue stenting (RS) has proven to be a feasible rescue therapy. However, the available evidence remains underpowered to assess clinical outcomes. We aimed to compare the safety and efficacy of RS versus routine medical management in patients with failed MT using an aggregated meta‐analysis.

Methods
A systematic review was performed from inception to July 2022 of all studies using RS after failed MT. Outcomes of interest included a modified Rankin scale score of 0–2 at 90 days, successful reperfusion (modified Thrombolysis in Cerebral Infarction 2b–3) after RS and symptomatic intracranial hemorrhage. A random‐effects meta‐analysis between the RS and medical treatment arms was performed to calculate pooled odds ratios (OR) for each outcome. We assessed the certainty of evidence using the Grading of Recommendation, Assessment, Development, and Evaluation approach. Statistical heterogeneity across studies was assessed with I2 statistics.

Results
A total of 12 studies included 1855 participants, 729 in the RS arm and 1126 in the medical treatment arm. The pooled results indicated that RS was associated with a significantly higher proportion of patients with a modified Rankin scale score of 0–2 at 90 days (RS: 41% versus 21%; OR,3.27; [95% CI 2.08–5.16]; I2=64%; moderate‐certainty evidence) and a decreased risk of mortality at 90 days (RS: 22.5% versus 33.8%; OR, 0.47; [95% CI 0.32–0.69]; I2=45%; low‐certainty evidence), compared with medical treatment after failed MT. The pooled rate of successful reperfusion after RS was 87% (95% CI 82–91; I2=57%; low‐certainty evidence). The rate of symptomatic intracranial hemorrhage did not differ between groups (RS: 8.5% versus 11.7%; OR, 0.85; [95% CI 0.59–1.20]; I2=7%; low‐certainty evidence).

Conclusion
RS is a promising strategy for maximizing recovery in acute stroke patients after first line MT fails to achieve meaningful reperfusion. However, randomized trials using a standardized approach/technique and MT failure definition are warranted to confirm these results.
Influence of different feeding rates of polychaete worms, Eulalia viridis (Annelida, Polychaeta), on the gonad development of male Penaeus semisulcatus (Decapoda, Dendrobranchiata) under captive conditions
Authors: Harini C. , Betsy C. Judith , Dattatreya P. Sri , Sampath Kumar J. Stephen 
Published: May 2023

Abstract
Penaeus semisulcatus is a large growing species, attaining a maximum size of about 250 mm in total length. It is more resistant to white spot syndrome virus (WSSV) than other cultivable penaeid shrimps, which makes it a potential candidate for culture. The present study evaluated the influence of a different feeding rate of polychaete worms on the gonad development of male P. semisulcatus under captive conditions. P. semisulcatus sub-adults were obtained in the wild. The shrimps were fed with three different concentrations of polychaete worms, viz., ad libitum (T1), 5% of body weight (BW) (T2) and 10% BW (T3), and fresh sardines were fed as a Control (C) diet, all for a period of 60 days. Sampling was done once in 15 days and the bio-growth parameters were recorded. The gonads were harvested for histological analysis. The maximum weight gain (10.19 g), mean weight gain percentage (85.20%), mean daily growth rate (DGR) (0.169833) and mean specific growth rate (SGR) (0.45) were found in shrimps fed with the polychaete worm diet at 5% BW. The estimated bio-growth parameter values were statistically significant when analysed using One way ANOVA (). Histological sections of the testis showed variations in the development of the gonad between the treatments with different feeding rates during the 60 days trials. Indeed in all aspects, the development was higher in shrimps fed with polychaete worms at 5% BW. It can be concluded that feeding polychaete worms at 5% BW created a regime able to improve growth rates, gonad maturation, and quality in the development of the captive male brood stock.
Vowel hiatus resolution in Koine Greek
Authors: Berenguer-Sánchez José A. 
Published: May 2023

Abstract
The spellings -ις, -ιν instead of -ιος, -ιον are a characteristic feature of Koine Greek. The circumstances in which they arose have constituted a vexed question. Their presence in Egyptian Greek documentary papyri from III BC to VIII AD stands out. Nowadays it is possible, thanks to new digital tools, to access all the regularized spellings in modern editions. Analysis and typological comparison allow us to rethink the hypotheses put forward in previous studies. In particular, it is useful not to study these spellings independently of the spellings -oῦ, -ῶ(ι) instead of -ίου, -ίω(ι). The graphic omission of ⟨o⟩ in some forms and of ⟨ι⟩ in others reflects different results of a vowel hiatus resolution process in sequences of increasing sonority [i.V(C)]. This process is gradient and different allophones could be represented by the same spelling. Of the possible factors for the omission of ⟨o⟩ or ⟨ι⟩, the word accent distribution is the basic cause determining the final form. However, as usually happens in processes of vowel hiatus resolution in other languages, other internal or external factors may also have influenced the results. Due to this gradience in the process and the distinction of glides of different types, the effect of V1 (converted into a glide) on the previous consonant could be different from what has been documented in [Cj] groups in other stages of Greek.
Classical Greek object cases
Authors: Murphy A.J. , Dubinsky Stanley 
Published: May 2023

Abstract
We examine here the distribution of morphological case (e.g., accusative, genitive, and dative) among object complements of monotransitive verbs in Classical Greek (CG). Accusative-marked objects are generally deemed to be direct objects (DO), while dative- and genitive-marked complements are typically treated as syntactically or semantically separate, sometimes being treated as objects bearing exceptional/semantic/quirky case and sometimes being analyzed simply as indirect objects (IO). Restricting our focus to verbs which have a single complement, we can observe that the distribution of accusative (ACC), genitive (GEN), and dative (DAT) marking on these in CG is atypical. CG productively places DAT and GEN NP s alongside ACC NP s as a singular complement to monotransitive verbs, allowing them to occupy what would normally be thought of as the direct-object position, but for their GEN and DAT case-marking. We offer an analysis of these verbs and their semanto-syntactic collocations, seeking to understand what is communicated through the marking of either ACC, GEN, or DAT on complement NP s. We find first that ACC and GEN-marking verbs interact in a transitivity hierarchy, being set apart by the change of state of the object (following an analysis laid out by Luraghi 2010). Second, we find that DAT-marking verbs exist outside of this hierarchy, making up their own productive class of interaction verbs, those which denote a complex series of overlapping subevents (first laid out by Blume 1998). Thus, this study offers an analysis of a wide array of ACC, GEN, and DAT case-marking verbs collected from a corpus of nine Classical Greek authors, providing the first statistical analysis of the conundrum of ‘atypical’ case-selection patterns of Classical Greek monotransitive verbs, wherein non-ACC cases are used to mark what appear to be DO s.
Linking Auditory-Induced Bouncing and Auditory-Induced Illusory Crescents: an Individual-Differences Approach
Authors: Meyerhoff Hauke S. , Stegemann Marlena J. , Frings Christian 
Published: May 2023

Abstract
When two disks move toward each other, overlap, and then move apart, the visual system can resolve the ambiguity either as two disks streaming past each other or two disks bouncing off each other. Presenting a brief beep at the moment of overlap has been observed to increase the proportion of reported bouncing impressions (i.e., auditory-induced bouncing) as well as to reduce the perceived overlap between the disks (leaving a larger uncovered crescent; auditory-induced illusory crescents). Previous research has speculated about the relationship between both variables, but no direct evidence has been reported yet. We present an individual-differences study in which our participants completed the bouncing/streaming task as well as the illusory crescent task on two consecutive days (to obtain test–retest reliabilities). We obtained acceptable to good reliabilities for the effect of the tone in both dependent measures. Most importantly, auditory-induced bouncing and auditory-induced illusory crescents were correlated in the moderate range suggesting that both illusions are related and share common underlying cognitions. Yet, moderate correlations also indicate that both measures partially capture distinct aspects of the object correspondence.
Significant West Antarctic Cooling in the Past Two Decades Driven by Tropical Pacific Forcing
Authors: Zhang Xueying , Wang Yetang , Hou Shugui , Heil Petra 
Published: May 2023

Abstract
During the second half of the twentieth century, the West Antarctic Ice Sheet (WAIS) has undergone significant warming at more than twice the global mean and thus is regarded as one of the most rapidly warming regions on Earth. However, a reversal of this trend was observed in the 1990s, resulting in regional cooling. In particular, during 1999–2018, the observed annual average surface air temperature had decreased at a statistically significant rate, with the strongest cooling in austral spring. The spring cooling correlates significantly with the second leading modes (EOF2) derived from empirical orthogonal function (EOF) analysis on the sea level pressure over Antarctica during 1999–2018, associated with the negative phase of the interdecadal Pacific oscillation with an average of cooling of central and eastern tropical Pacific surface sea temperature (SST) anomalies. The EOF2 results in the enhanced cold southerly winds on the continental WAIS through the cyclonic conditions over the Amundsen Sea region and a blocking high in the Drake Passage and northern Antarctic Peninsula, causing the WAIS cooling trend.
Predictability of Marine Heatwaves off Western Australia Using a Linear Inverse Model
Authors: Wang Yuxin , Holbrook Neil J. , Kajtar Jules B. 
Published: May 2023

Abstract
Marine heatwaves (MHWs) off Western Australia (110°–116°E, 22°–32°S; herein, WA MHWs) can cause devastating ecological impacts, as was evidenced by the 2011 extreme event. Previous studies suggest that La Niña is the major large-scale driver of WA MHWs, while the Indian Ocean dipole (IOD) may also play a role. Here, we investigate historical WA MHWs and their connections to these large-scale climate modes in an ocean model (ACCESS-OM2) simulation driven by a prescribed atmosphere from JRA-55-do over 1959–2018. Rather than analyzing sea surface temperature, the WA MHWs and climate mode indices were characterized and investigated in vertically averaged temperature (VAT) to ∼300-m depth to afford the longer ocean dynamic time scales, including remote oceanic connections. We develop a cyclostationary linear inverse model (CS-LIM; from 35°S to 10°N, across the Indo-Pacific Ocean), to investigate the relative contributions of La Niña VAT and positive IOD VAT to the predictability of WA VAT MHWs. Using a large ensemble of CS-LIM simulations, we found that ∼50% of WA MHWs were preceded about 5 months by La Niña, and 30% of the MHWs by positive IOD about 20 months prior. While precursor La Niña or positive IOD, on their own, were found to correspond with increased WA MHW likelihood in the months following (∼2.7 times or ∼1.5 times more likely than by chance, respectively), in combination these climate mode phases were found to produce the largest enhancement in MHW likelihood (∼3.2 times more likely than by chance). Additionally, we found that stronger and longer La Niña and/or positive IOD tend to lead stronger and longer WA MHWs.

Significance Statement
This study examines seasonal-to-interannual time-scale predictability of marine heatwaves off Western Australia. We developed and applied a linear inverse model, informed by numerical model results, to generate a large number of 60-yr temperature simulations across the broader Indian–Pacific Ocean region to quantify this marine heatwave predictability. We found that La Niña typically increases the likelihood of marine heatwaves off Western Australia about 5 months (3–7 months) later, while positive Indian Ocean dipole events increase their likelihood about 20 months (18–22 months) later. Marine heatwaves can severely impact local marine ecosystems and the economy. Our findings are expected to be valuable for marine heatwave prediction system development on time scales that can be beneficial to marine ecosystem conservation and fishery management.
Correcting Nonstationary Sea Surface Temperature Bias in NCEP CFSv2 Using Ensemble-Based Neural Networks
Authors: Yang Ziying , Liu Jiping , Yang Chao-Yuan , Hu Yongyun 
Published: May 2023

Abstract
Sea surface temperature (SST) forecast products from the NCEP Climate Forecast System (CFSv2) that are widely used in climate research and prediction have nonstationary bias. In this study, we develop single- (ANN1) and three-hidden-layer (ANN3) neural networks and examine their ability to correct the SST bias in the NCEP CFSv2 extended seasonal forecast starting from July in the extratropical Northern Hemisphere. Our results show that the ensemble-based ANN1 and ANN3 can reduce the uncertainty associated with parameters assigned initially and dependence on random sampling. Overall, ANN1 reduces RMSE of the CFSv2 forecast SST substantially by 0.35°C (0.34°C) for the testing (training) data and ANN3 further reduces RMSE relatively by 0.49°C (0.47°C). Both the ensemble-based ANN1 and ANN3 can significantly reduce the spatially and temporally varying bias of the CFSv2 forecast SST in the Pacific and Atlantic Oceans, and ANN3 shows better agreement with the observation than that of ANN1 in some subregions.

Significance Statement
Global coupled climate models are the primary tool for climate simulation and prediction and provide initial and boundary conditions to drive regional climate models. SST is an essential climate variable simulated and forecast by global climate models, which suffers substantial biases both spatially and temporally. We apply the ensemble averaging of both single- and three-hidden-layer neural networks on the NCEP CFSv2 SST forecast. They can correct the identified SST error, though ANN3 performs relatively better than that of ANN1. Thus, ensemble-based ANN3 is a useful SST bias correction approach.
Five-Year Climatology and Composite Study of Precipitation Bands Associated with Extratropical Cyclones over the British Isles
Authors: Zhang Tianhang , Schultz David M. 
Published: May 2023

Abstract
A 5-yr climatology and composite study of precipitation bands associated with extratropical cyclones over the British Isles from April 2017 to March 2022 is constructed. A total of 249 single bands were manually identified from radar network mosaics in association with 167 cyclones identified from surface maps. More bands formed over water near the coast than over inland areas, and most had a meridional orientation. The average lengths of bands at the times of formation and maximum length were 290 and 460 km, respectively; only 20% of bands reached a maximum length exceeding 600 km. The number of bands decreased with increasing duration, with 31% of bands lasting for 2–3 h, with bands lasting more than 10 h uncommon. The bands were classified into six categories, with occluded-frontal bands (19 yr−1), warm-frontal bands (11 yr−1), and cold-frontal bands (10 yr−1) being the most frequent. Occluded-frontal and warm-frontal bands commonly occurred west of Scotland and in the east quadrant relative to their parent cyclones. In contrast, cold-frontal bands commonly occurred southwest of Great Britain and in the south quadrant relative to their parent cyclones. Composites for northwest–southeast occluded-frontal and warm-frontal bands west of Scotland, and southwest–northeast cold-frontal bands southwest of Great Britain, show the different synoptic environments that favor bands. The low-level jet transports moisture into the band and is similar to the location and scale of the composite bands, similar to that of an atmospheric river. These results are compared to previous studies on bands from the United States.

Significance Statement
Precipitation bands are lines of heavy precipitation as seen on weather radar. Most studies of bands in extratropical cyclones have occurred in the United States. We examine 5 years of bands in extratropical cyclones over the British Isles to better understand their characteristics. Bands form in preferred geographic regions: offshore of the west coasts of Scotland, Wales, and southwest England. The most common bands are associated with occluded fronts (37% of all bands). The average scale of the bands is associated with the average scale of wind maxima 1–2 km above ground. These results provide a better understanding of the typical characteristics and conditions under which bands form and their geographical variability compared to the United States.
Adolescence Stress Scale: Development and Standardization
Authors: Hariharan Meena , Padhy Meera , Monteiro Sandra Roshni , Nakka Laxmi Priyanka , Chivukula Usha 
Published: May 2023

Background/Aim: The objective of the paper was to develop a comprehensive “Adolescence Stress Scale” and to examine different psychometric issues in the development, initial validation, and standardization of this scale. Method: Exploratory factor analysis was conducted on the data procured from a sample of 634 (11–18 years) school-going adolescents in India. Results: An exploratory analysis provided a 10 factor structure, namely, major loss induced stress, enforcement or conflict induced stress, phobic stress, interpersonal conflict induced stress, punishment induced stress, illness and injury induced stress, performance stress, imposition induced stress, insecurity induced stress, unhealthy environment induced stress. The 10 oblique factor solutions are found to be interrelated and interdependent with good indices of internal consistency, and content validity. Conclusions: This scale development is a novel and powerful measure that taps onto various aspects of stress experienced by school-going adolescents. The scale can facilitate researchers, clinicians, and teachers to identify and quantify the significant sources of stress in adolescents in school, or clinic settings.