bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of sex differences in percentage of body fat on speed and endurance running performance
Authors: Asma Kacem , Ghassen Ben Mansour , Laurent Grélot , Foued Ftaiti 
Published: June 2023

Abstract
Purpose – Technological developments over the past two decades induced lifestyle changes such as high TV-viewing and high computer/tablet/smartphone and increase population physical inactivity. This change in lifestyle can affect young people and adults of both sexes differently and modify or reverse the well-known male-female morphological and physical differences. The aim of this study is to compare the effect of sex differences in percentage of body fat on speed and endurance running performance. Methods − 72 male and 64 female students aged 20 to 23 years participated in this study. After assessing their morphological characteristics, running performances during 30 m and 400 m, and maximum aerobic velocity (MAV) and maximal oxygen consumption (VO2max) during a 20 m shuttle running test have been estimated for each subject. Male students were re-tested after being overweighed down with a weight equivalent to the mean differences in body fat recorded between the two sexes in the form of a loaded worn vest. Results – Male are 15,7% heavier and 7,4% taller (p < 0.001) and presented a percentage of fat mass (17.2 ± 2%) significantly (p < 0.001) lower than that of women subject (25.0 ± 2.5%) (difference male vs female for body fat mass: 45.34%). Running performances during 30 m and 400 m, MAV and VO2max were significantly (p < 0.001) better in males (4.81 ± 0.11 sec, 61.97 ± 2.63 sec, 12.53 ± 0.54 km/h and 49.67 ± 3.3 ml/min/kg, respectively) than in females (5.58 ± 0.31 sec, 87.95 ± 8.93 sec, 10.38 ± 0.57 km/h and 37.22 ± 3.31 ml/min/kg, respectively) In the weighted condition, male performances during 30 m and 400 m, MAV and VO2max were attenuated by 6.89%, 14.16%, 6.48% and 10.07%, respectively) but remain significantly better than those of female students. Conclusion - Excess body fat in female students has a detrimental effect (range ≈ -7 to -14%) on 30 m, 400 m, MAV and VO2max performances. The persistence of sex differences after overweighting male students indicates that body fat could be responsible for ≈ 50 to 70% of the observed differences between sexes performances during short and long sprints, and 20 m shuttle running test.
Limitation of Cerebral Blood Flow by Increased Venous Outflow Resistance in Elevated ICP
Authors: Zadka Yuliya , Rosenthal Guy , Doron Omer , Barnea Ofer 
Published: June 2023

Abstract
Background
Extensive investigation and modeling efforts have been dedicated to cerebral pressure autoregulation, which is primarily regulated by the cerebral arterioles ability to change their resistance and modulate cerebral blood flow (CBF). However, the mechanisms by which elevated intracranial pressure (ICP) leads to increased resistance to venous outflow have received less attention. We modified our previously described model of intracranial fluid interactions with a newly developed model of a partially collapsed blood vessel, which we termed the “Flow Control Zone” (FCZ). We sought to determine the degree to which ICP elevation causing venous compression at the FCZ becomes the main parameter limiting CBF.
Methods
The FCZ component was designed using non-linear functions representing resistance as a function of cross-sectional area and the pressure-volume relations of the vessel wall. We used our previously described swine model of cerebral edema with graduated elevation of ICP to calculate venous outflow resistance (VOR) and a newly defined parameter, the cerebral resistance index (CRI), which is the ratio between venous outflow resistance and cerebrovascular resistance.
Results
Model simulations of cerebral edema and increased ICP led to increased venous outflow resistance. There was a close similarity between model predictions of venous outflow resistance and experimental results in the swine model (cross correlation coefficient of 0.97). CRI was strongly correlated to ICP in the swine model (r2 = 0.77, p < 0.0001). A CRI value of 0.5 was associated with ICP values above clinically significant thresholds (23.7 mm Hg) in the swine model and a diminished the capacity of changes in arteriolar resistance to influence flow in the mathematical model.
Conclusions
Our results demonstrate the importance of venous compression at the FCZ in determining CBF when ICP is elevated. The cerebral resistance index may provide an indication of when compression of venous outflow becomes the dominant factor in limiting CBF following brain injury.
Chest computed tomography characteristics of critically ill COVID-19 patients with auto-antibodies against type I interferons
Authors: Rapnouil Baptiste Lafont , Zaarour Youssef , Arrestier Romain , Bastard Paul , Peiffer Bastien , Moncomble Elsa , Parfait Mélodie , Bellaïche Raphaël , Casanova Jean-Laurent , Mekontso-Dessap Armand , Mule Sébastien , de Prost Nicolas 
Published: June 2023

Abstract
Purpose: patients with auto-antibodies neutralizing type I interferons (anti-IFN auto-Abs) are at risk of severe forms of coronavirus disease 19 (COVID-19). The chest computed tomography (CT) scan characteristics of critically ill COVID-19 patients harboring these auto-Abs have never been reported.
Methods: Bicentric ancillary study of the ANTICOV study (observational prospective cohort of severe COVID-19 patients admitted to the intensive care unit (ICU) for hypoxemic acute respiratory failure) on chest CT scan characteristics (severity score, parenchymal, pleural, vascular patterns). Anti-IFN auto-Abs were detected using a luciferase neutralization reporting assay. Imaging data were collected through independent blinded reading of two thoracic radiologists of chest CT studies performed at ICU admission (±72h). The primary outcome measure was the evaluation of severity by the total severity score (TSS) and the CT severity score (CTSS) according to the presence or absence of anti-IFN auto-Abs.
Results: 231 critically ill COVID-19 patients were included in the study (mean age 59.5±12.7 years; males 74.6%). Day 90 mortality was 29.5% (n=72/244). There was a trend towards more severe radiological lesions in patients with auto-IFN anti-Abs than in others, not reaching statistical significance (median CTSS 27.5 (21.0-34.8] versus 24.0 (19.0-30.0), p=0.052; median TSS 14.5 (10.2-17.0) versus 12.0 (9.0-15.0), p=0.070). The extra-parenchymal evaluation found no difference in the proportion of patients with pleural effusion, mediastinal lymphadenopathy or thymal abnormalities in the two populations. The prevalence of pulmonary embolism was not significantly different between groups (8.7% versus 5.3%, p=0.623, n=175).
Conclusion: There was no significant difference in disease severity as evaluated by chest CT in severe COVID-19 patients admitted to the ICU for hypoxemic acute respiratory failure with or without anti-IFN auto-Abs.
Facilitators and barriers to implementing a specialized care unit for persons with cognitive impairment in an acute geriatric hospital: A process evaluation
Authors: Adlbrecht Laura , Karrer Melanie , Helfenberger Nicole , Ziegler Eva , Zeller Adelheid 
Published: June 2023

Abstract
Background: Implementing dementia care interventions in an acute hospital poses multiple challenges. To understand factors influencing the implementation, in-depth knowledge about specific facilitators and barriers is necessary. The aim of this study was to identify facilitators and barriers to implementing a multicomponent, interprofessional concept of a specialized unit for persons with cognitive impairment in an acute geriatric hospital.
Methods:We conducted a process evaluation as part of a participatory action research study. For data collection, semi-structured individual interviews with fifteen professionals involved in the implementation of the specialized unit. We further conducted two focus groups with twelve professionals working on other units of the geriatric hospital. We performed a qualitative content analysis following Kuckartz’s content-structuring analysis scheme.
Results: We identified the following barriers to implementing the concept: uncontrollable contextual changes (e.g., COVID-19 pandemic), staff turnover in key functions, high fluctuation in the nursing team, traditional work culture, entrenched structures, inflexible and efficiency-oriented processes, monoprofessional attitude, neglect of project-related communication, and fragmentation of interprofessional cooperation. An established culture of interprofessionalism, an interprofessionally composed project group, cooperation with a research partner, as well as the project groups’ motivation and competence of managing change facilitated the implementation.
Conclusions: The implementation faced numerous barriers that can be described using the key constructs of the i-PARIHS framework: context, recipients, innovation, and facilitation. Overcoming these barriers requires an organizational development approach, extended project duration and increased process orientation. Furthermore, strategically planned, precise and ongoing communication towards all persons involved seems crucial. Differences between the work cultures of the professions involved deserve particular attention with regard to project-related roles and processes.
Accuracy of robotic arm-assisted versus computed tomography-based navigation for cup orientation and positioning in total hip arthroplasty using the direct anterior approach in supine position
Authors: Okazaki Tomoya , Imagama Takashi , Matsuki Yuta , Tanaka Hiroshi , Shiigi Eiichi , Kaneoka Takehiro , Kawakami Takehiro , Yamazaki Kazuhiro , Sakai Takashi 
Published: June 2023

Abstract
Background
A robotic arm-assisted and a computed tomography (CT)-based navigation system have been reported to improve the accuracy of component positioning in total hip arthroplasty (THA). Although some previous studies have compared robotic arm-assisted THA (rTHA) with CT-based navigated THA (nTHA), most studies evaluated the outcomes in the lateral position. No study has compared rTHA to nTHA concerning accuracy of cup placement and acetabular fractures using the direct anterior approach (DAA) in supine position. This study aimed to compare the accuracy of cup placement and the presence of intraoperative acetabular fractures between rTHA and nTHA using DAA in supine position.
Methods
We retrospectively investigated 209 hips of 188 patients who underwent rTHA or nTHA using DAA in supine position (rTHA using the Mako system: 85 hips of 79 patients; nTHA: 124 hips of 109 patients). After propensity score matching for age and sex, each group consisted of 73 hips. Postoperative cup orientation and positions measured using a three-dimensional templating software were compared to preoperative planning with CT measurements. Additionally, we investigated the prevalence of occult acetabular fracture.
Results
The mean absolute error of cup orientation was significant smaller in the rTHA group than in nTHA (inclination: 1.4° ± 1.2° vs 2.7° ± 2.2°, respectively; p = 0.0001, anteversion: 1.5° ± 1.3° vs 2.2° ± 1.7°, respectively; p = 0.007). The cases within an absolute error of 5 degrees in both RI and RA were significantly higher in the rTHA (97.3%) than in nTHA group (82.2%) (p = 0.003). The absolute error of the cup position was not significantly different between the two groups. The prevalence of occult acetabular fracture did not differ significantly between the two groups (rTHA: n = 0 [0%] vs. nTHA: n = 1 [1.4%]).
Conclusion
Cup placement using DAA in the supine position in rTHA was more accurate with fewer outliers compared to nTHA. Therefore, rTHA performed via DAA in a supine position would be useful for accurate cup placement.
High burnout among maternity healthcare workers in Zomba and Lilongwe, Malawi
Authors: Singano Fikile Khangamwa , Mazengera Rose , Mbendela Ida , Singano Victor 
Published: June 2023

Abstract
Background Burnout is prevalent among healthcare workers due to chronic stress of patients suffering. In Malawi burnout has not been properly investigated in the maternity facilities, however it is believed that there are high burnout levels among maternal health care workers due to the high patient to provider ratio, poor remuneration and heavy work load. Therefore, the study aimed to assess the extent and factors associated with burnout among maternity health care workers at two hospitals (Zomba Central Hospital and Bwaila Hospital) in Malawi.Methods We conducted a cross-sectional study among maternity health care workers at Zomba Central Hospital and Bwaila Hospital in June 2018. Demographic data and constructs of burnouts (emotional exhaustion, depersonalization and reduced personal accomplishments) were collected using a validated adapted Maslach Burnout Inventory self-administered questionnaire.Results We enrolled 81 participants in the study, with a mean age 32 years (SD: 6.2); 68% were female; and 85% were nurse/midwives. 62% of the participants were from Bwaila Hospital and 38% from Zomba Central Hospital. The burnout rates on emotional exhaustion, depersonalization and reduced personal accomplishment on the Maslach Burnout Inventory Scale were 75%, 28% and 33%, respectively. In multivariate analysis, healthcare worker absenteeism (adjusted OR {P-value} 15.38(0.05) and low job satisfaction (adjusted OR {P-value} 17.72(0.02) were associated with emotional exhaustion. Working at Zomba Central Hospital (adjusted OR {P-value} 10.06(0.022), working in the labour and antenatal wards (adjusted OR {P-value} 0.166(0.047) low job satisfaction (adjusted OR {P-value} 0.056(0.023) and discussing work situation with colleagues (adjusted OR {P-value} 0.122(0.026) were associated with reduced personal accomplishment. healthcare worker absenteeism (adjusted OR {P-value} 9.91(0.05) was associated with depersonalisation.Conclusion There was a high burnout rate among maternity health care workers with high absenteeism rates.
Prognostic Factors of Classic Kaposi’s Sarcoma in the Hainan Area
Authors: Zhang Haihang , Xie Panpan , Han Fengxiang , Fu Yu , Wu Yi , Zeng Jiangzheng , Zheng Liping , Lu Yanda 
Published: June 2023

Abstract
Background: Hainan Province is situated at the southernmost tip of the People's Republic of China, within the northern tropical belt. However, the risk factors for classic Kaposi's sarcoma in this region remain unknown. To explore the prognostic factors for patients with classic Kaposi’s sarcoma (CKS) and develop a nomogram to quantitatively predict cancer-specific survival (CSS) probability.
Methods: This study retrospectively analyzed the clinical data of 42 CKS patients admitted between January 1999 and June 2022. Univariate analysis was performed to screen for significant variables, which were then included in a multivariate Cox regression analysis to futher investigate their impact. A nomogram was developed to predict patient CSS, and its performance was evaluated using an ROC curve.
Results: All patients were middle-aged and elderly, and there were significantly more males than females, with a male-to-female ratio of 4.2:1 Univariate analysis found several factors that might influence CKS prognosis, including sex, race, stage, lower limb lesions, concurrent upper and lower limb lesions, white blood cells(WBCs), hemoglobin(Hb), and human herpesvirus 8 (HHV-8) (P < 0.05). Multi-factor analysis showed that sex (hazard ratio [HR]: 0.146, confidence interval [CI]: 0.033–0.648, P = 0.011) and race (HR: 0.229, CI: 0.065–0.803, P < 0.021) were protective factors, while stage (HR: 3.728, CI: 1.015–13.695, P < 0.047) was an independent risk factor. The nomogram constructed from these factors had better predictive performance than sex, ethnicity, and stage.
Conclusions: Sex, nationality, and stage were independent factors influencing CKS prognosis, and the constructed nomogram could aid in survival estimation and individualized treatment decisions.
Pelvic Lipomatosis: Bladder Sparing Extirpation of Pelvic Mass with Ureteral Reimplantation
Authors: Albalawi Abdulaziz , Alhassan Abdullatif , Alanazi Abdullah , Alghamdi Abdullah 
Published: June 2023

Abstract
Background Pelvic lipomatosis is a proliferative disease characterised by excessive fat growth in retroperitoneal space leading to inadequate bladder drainage and ureteral compression. Cystitis glandularis, cystitis cystica, or cystitis follicularis can be found in majority of patients with the disease.Case Presentation We report a case of a 63-year-old man diagnosed outside our hospital with pelvic lipomatosis after finding of pelvic mass behind the bladder causing severe bilateral hydronephrosis. A bladder–sparing excision of the pelvic lipomatosis mass with bilateral ureteric reimplantation was performed, thereby avoiding the need for urinary diversion.Conclusion For patients suffering from pelvic lipomatosis and bilateral hydronephrosis, relief of obstructions to the urinary tract should be prioritized. This can be achieved through traditional surgery such as a ureteral stent insertion, or more radical surgical options such as a total cystectomy and urinary diversion. There have been recent reports of success found in bladder-sparing techniques using mass extirpation and ureteral reimplantation.
E-Peer Assisted Reflection (E-PAR) and Development in Discussion Board; An analysis of Medical Students’ Opinions
Authors: Mosalanejad Leili , Maghsodzadeh Sara , Karamzadeh Atefeh , Karimian Zahra 
Published: June 2023

Abstract
Introduction: Reflection is the process of critical reviewing what students have learned. The purpose of this study was to analyze medical students' opinions on e-peer-assisted reflection and development in a forum.
Methods: This study was conducted using a qualitative approach and content analysis methods. The study sample included all opinions experienced in 16 forums by 292 students of medicine, laboratory science, and public health at 0000 University of Medical Sciences (0000). The teacher presented the course concept to the class and asked questions based on the learning management system's (LMS) discussion forum. Students will then respond to it according to the requested time and time frame. After each course, we surveyed students' experiences of discussion and question-and-answer sessions in a forum environment. Data were analyzed by inductive content analysis, first open code was extracted and then classified based on semantic and thematic similarity. Three peers checked the categories and codings.
Results: The data were finally classified into two general categories: effectiveness and setting included Effectiveness [Peer Assisted Learning (11Items), Thinking (11Items), Active Learning(8Items), Self-critique(5Items)] and Setting [Environment(7Items), Teachers (7Items) and Students(2Items)] the repetition rate of each item was recorded.
Conclusion: It seems that is an appropriate method of enhancing student learning and appears to be effective in enhancing their reasoning, participation, and comprehension.
PTPN3 inhibition contributes to the activation of the dendritic cell function to augment the effect of cancer immunotherapy
Authors: Iwamoto Naoya , Onishi Hideya , Masuda Syogo , Imaizumi Akira , Sakanashi Keita , Morisaki Shinji , Nagao Shinjiro , Koga Satoko , Ozono Keigo , Umebayashi Masayo , Morisaki Takashi , Nakamura Masafumi 
Published: June 2023

Abstract
In a previous study, protein tyrosine phosphatase non-receptor type (PTPN) 3 was identified as an immune checkpoint molecule in lymphocytes, and its potential as a novel therapeutic target for cancer immunotherapy was anticipated. However, evaluation of dendritic cell (DC) function as antigen-presenting cells is critical for development of immunotherapy. This study aimed to analyze the biological effect of PTPN3 on DCs induced from human peripheral blood monocytes obtained from healthy individuals. PTPN3 knockdown by siRNA significantly increased the number of DCs, the expression of CD80 and CCR7, and the production of IL-12p40/p70 in mature DCs. Using an HLA-A24-restricted DC and human lung squamous cell carcinoma cell cytotoxic assay, PTPN3 inhibition in mature DCs induced cytotoxic T lymphocytes with increased production of INF-γ and granzyme B and enhanced cytotoxicity against cancer cells and migration to cancer. Furthermore, PTPN3 inhibition activated the MAPK pathway in DCs. These findings suggest that PTPN3 inhibition can contribute to the development of novel cancer immunotherapies that not only activate lymphocytes, as previously reported, but also activate DCs.
A note on area estimates for stable H-hypersurfaces and applications
Authors: Ranieri Marcos , Sampaio Elaine , Vitório Feliciano 
Published: June 2023

Abstract
We show some area estimates for stable CMC hypersurfaces which the ambient manifold haseither the scalar or sectional curvature bounded from below. In particular, we focus on immersions in three dimensional Riemannian manifolds. As application we derive upper estimates for the bottom spectrum of these hypersurfaces. The technique and most of our results are generalizations of the theorems obtained in [20] for stable minimal surfaces.
Journal Of Big Data: A Bibliometric Analysis
Authors: Mishra Puneet , Bhardwaj Manik 
Published: June 2023

Abstract

The Journal of Big Data has been a leading international journal in Decision Sciences and Computer Sciences. The goal of this research is to look into the Journal of Big Data's bibliometric attributes through scientific activity based on journal article citation links. Using a bibliometric approach, this study examines all of the journal's publications since its inception. The goal is to provide a comprehensive overview of the major factors influencing the journal. This analysis covers key issues such as the journal's publication and citation structure, the most cited articles, and the journal's leading authors, institutions, and countries. The network analysis was performed to look into author keywords through Journal of Big Data publications. The software that was utilized to create this analysis of present patterns and potential future developments was Scopus, Rstudio, and Vosviewer. A bibliometric study was utilized to examine articles and review papers, and only works published in the Scopus database between 2014 and 2021 were considered. The information on each manuscript's bibliometric was acquired after the findings were clearly explained. The initial findings included 632 articles.
Attention to detail – exploring effects on technology selection in geospatial electrification modelling
Authors: Sahlberg Andreas , Korkovelos Alexandros , Kabongo Christian , Trujillo Cristian , Khavari Babak , Nerini Francesco Fuso 
Published: June 2023

Abstract
As of 2021, 675 million people globally lack access to electricity. Geospatial electrification tools can be used to identify the mix of grid-extension, mini-grids and stand-alone technologies that can supply currently unelectrified areas at the lowest cost. Several such tools have been developed, at different levels of modelling detail and complexity. In this paper, we improve the Open Source Spatial Electrification Tool (OnSSET) to develop a flexible geospatial electrification tool that can still run lighter rapid assessments for a first estimate of the technology split, but now also more detailed analysis with higher spatial and temporal resolution used for grid routing, distribution network design and optimization of hybrid mini-grid generation introduced through new algorithms. We compare the existing light and new detailed versions of the tool through a case study of the north-western parts of the Democratic Republic of the Congo. We find that the new grid routing algorithm lead to more off-grid technologies, and that the detailed design of distribution networks lead to a reduction in stand-alone technologies. The detailed optimization of hybrid mini-grids display varying effects at different demand levels. Given the increased computational effort that is observed with higher modelling detail, we discuss the implications for scenario design and selection of geospatial electrification tool for future analyses aiming to support the achievement of SDG 7.