bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between parenting styles and adolescent problematic Internet use: A three-level meta-analysis
Authors: Niu Xiang , Li Jie-yang , King Daniel L. , Rost Detlef H. , Wang Hai-Zhen , Wang Jin-Liang 
Published: September 2023

AbstractBackground and aimsProblematic Internet use (PIU) has become a global public health problem. It has been suggested that parenting style is associated with adolescent PIU. However, the evidence in favor of this view is mixed. Based on the PRISMA method, the present study employed three-level meta-analysis approach to investigate the relationship between these two variables and further explore potential moderators.MethodsAfter a systematic search for published articles, 35 studies were included, reporting 171 effect sizes (N = 40,587).ResultsThe results showed that positive parenting styles were significantly negatively related to PIU. This association was moderated by gender, age, publication year, and measurements of PIU, but was not by culture and measurements of parenting styles. Negative parenting styles were significantly positively related to PIU, which was moderated by publication year, culture, and sub-types of negative parenting, but not by gender, age, and measurements of both parenting styles and PIU. In addition, the correlation of PIU with negative parenting styles was stronger than that with positive parenting styles.Discussion and ConclusionsThe present results demonstrated that parenting styles, especially punitive parenting styles, should be attached to more important when treating adolescent PIU.
A função dos morfemas categorizadores na Língua Guajá
Authors: Magalhães Marina Maria Silva , Mello Jorge Elias Matta de 
Published: September 2023

Este estudo trata da investigação de morfemas da língua Guajá cuja função é categorizar o mundo em domínios relevantes para seus falantes construindo a referência do nome ou definindo o escopo do evento a partir de uma categoria prototípica baseada em traços de propriedades determinados pela cosmovisão dos Awa Guajá. Utilizando os conceitos de categorização linguística e protótipo, analisamos esses morfemas como constituindo um conjunto de sufixos que definem entidades e eventos em termos do quanto se distanciam ou se aproximam de um protótipo no que diz respeito à dimensão/intensidade (-hu e -ˈi) ou a semelhanças não expressas descritivamente (-rỹ) ou mesmo no que se refere a seus traços autênticos quando contrastados com referentes ou eventos similares (-te).
El acceso a la universidad en Argentina
Authors: Garcia Pablo Daniel 
Published: September 2023

Introducción/Objetivo: El presente artículo pone su foco de análisis en los dispositivos y regulaciones que organizan el ingreso a la universidad pública en Argentina, con un especial foco en las universidades nacionales ubicadas en el Conurbano bonaerense. A partir de considerar el contexto sociodemográfico en el que funcionan las Universidades del Conurbano bonaerense, se presentan algunas especificidades sobre su creación y organización institucional/académica. Dado que el foco del artículo se encuentra en los dispositivos y regulaciones para el ingreso, se presenta una caracterización de los nuevos ingresantes a las mencionadas universidades, en términos de la evolución reciente de matriculación anual y a partir de su inserción laboral y la trayectoria educativa de sus familias. Metodología: A partir de esta contextualización, se presentan las características fundamentales de los dispositivos reguladores del ingreso construidos en cada universidad y se analiza, desde una perspectiva comparada, sus modos de organización en lo que respecta a su institucionalización, duración, modalidad de cursada, composición de los espacios curriculares que cada dispositivo incluye y las modalidades de aprobación previstas. Resultados/Conclusión: Para finalizar el artículo se enuncian para la discusión algunas reflexiones en torno a la vinculación entre estos dispositivos y regulaciones para el ingreso y los desafíos que enfrenta la universidad pública contemporánea.
A mobile device to investigate the response of grapevine berries to heat stress
Authors: Heilemann Müller Kai Konstantin , Stoll Manfred , Hofmann Marco , Friedel Matthias 
Published: September 2023

Reproducibly comparing the heat stress response of grapevine berries from different cultivars in the field is often limited by weather conditions during the growing season. This work presents a mobile heating device capable of controlled heat-stress induction on grapevine berries. The heater consisted of six 150 W infrared lamps mounted in a profile frame. The heating power of the lamps could be set individually by a control unit consisting of a single board computer and six temperature sensors positioned as desired. The heat energy applied to individual berries within a cluster decreases by the squared distance to the heat source, enabling the establishment of temperature profiles within individual clusters. Infrared thermography of the fruit surface and measurements conducted with a thermocouple inserted at the epidermis level showed comparable temperatures. Berries treated with high temperatures were sampled according to their visual appearance (i.e., sunburn symptoms). Only symptomatic berries showed a significant increase in electrolyte leakage, indicating cell damage. In a field experiment, the induction of sunburn necrosis symptoms with the presented device was used to predict a Lethal Dose (LD50) for sunburn necrosis symptoms of the Vitis vinifera L. cultivars Bacchus and Silvaner. The LD50 of Bacchus, known as a heat-sensitive cultivar, was about 3.2 °C lower than that of Silvaner. The presented device offers possibilities for a wide range of applications and the induction of precise temperature dynamics in the context of heat stress on fleshy fruit.
<i>Agaricus bisporus</i> chitosan influences the concentrations of caftaric acid and furan-derived compounds in Pinot noir juice and base wine
Authors: Mederios Jacob , Xu Shufen , Pickering Gary , Kemp Belinda 
Published: September 2023

Chitosan is a fining agent used in winemaking, although its use in juice and wine beyond fining has been limited until now. Therefore, this study's first aim was to determine if chitosan derived from Agaricus bisporus (button mushrooms) could reduce caffeic and caftaric acid concentrations in Pinot noir grape juice (Study A). The second aim was to determine if chitosan, when added to base wine, could influence the synthesis of furan-derived compounds during storage (Study B). In Study A, Pinot noir grape juice was stored at 10 °C for 18 hours after the following treatments: control (no addition), bentonite/activated charcoal (BAC), low molecular weight (< 3 kDa; LMW) chitosan, med. MW (250 kDa; MMW) chitosan, and high MW (422 kDa; HMW) chitosan (all 1 g/L additions). Caftaric acid was decreased, and total amino acid concentration was increased in the LMW chitosan-treated juice, while the estimated total hydroxycinnamic acid content, turbidity, and browning were decreased in the MMW chitosan-treated juice compared to the control. In Study B, Pinot noir base wine destined for sparkling wine was stored at 15 and 30 °C for 90 days with the following treatments: control (no addition), LMW chitosan, MMW chitosan, and HMW chitosan (all 1 g/L additions). The three chitosan treatments stored at 30 °C had increased furfural, homofuraneol, and 5-methylfurfural formation in the base wine compared to the control. At 15 °C, furfural and homofuraneol had greater concentrations in all chitosan-treated wines after 90 days of storage. Our results demonstrate the potential of mushroom-derived chitosan to remove caftaric acid from grape juice and suggest that chitosan can influence the synthesis of furan-derived compounds in wine after short-term storage.
Cow-calf management practices in Mexico: dual-purpose cattle
Authors: Lassala Arantzatzu , Alonso-Díaz Miguel Ángel , Corro-Morales Manuel Dionisio , González-Padilla Everardo , Aguilar Carlos Gutierrez 
Published: September 2023

Abstract

This study aimed to characterise management practices of dual-purpose (DP) cattle production systems across Mexico through a structured questionnaire answered by 996 farmers. The predominant type of cattle found in DP operations was European dairy x Zebu crossbreeds (54.7%). These cattle were most popular in the tropics with 78% and 56% for the humid and dry tropics, respectively. In contrast, temperate climate farmers prefer European beef x Zebu crossbreeds (63.1%). Weaned calves and dairy products were the primary goods of DP systems. More operations sell raw milk in temperate climates than in arid and tropical climates. Ninety one percent of DP farms milk their cows manually, whilst only 8.6% use mechanical milking. Cows are milked once daily in 93% of farms. The main calf-rearing system is by allowing the calf to suckle (95.1%), with only 4.9% of operations using artificial rearing methods. Milk letdown was most frequently induced by the calf (73.2%), but 13.9% of operations used oxytocin stimulation. Only 6.3% of operations have milk cooling systems. Regarding sanitary practices, 73.5% of farms reported cleaning the teats prior to milking. Teat dipping after milking was generally low (10.5%), owing to the calf feeding on remanent milk. In addition, only 18% of DP operations routinely use mastitis diagnosis tests. Given the importance of dual purpose for local economies, improvements in market integration, technical assistance, and technology appropriation are paramount for the future development of this sector.
Enhancing Deep Learning Predictive Models with HAPPY (Hierarchically Abstracted rePeat unit of PolYmers) Representation
Authors: Hur Su-Mi , Ahn Jihun , Irianti Gabriella , Choe Yeojin 
Published: September 2023

Abstract

We introduce HAPPY (Hierarchically Abstracted rePeat unit of PolYmers), a new string representation for polymers, designed to efficiently encapsulate essential polymer structure features for property prediction. HAPPY assigns single constituent elements for groups of sub-structures and employs grammatically complete and independent connectors between chemical linkages. Using a limited number of datasets, we trained neural networks represented by both HAPPY and conventional SMILES encoding of repeated unit structures and compared their performance in predicting five polymer properties: dielectric constant, glass transition temperature, thermal conductivity, solubility, and density. The results showed that the HAPPY-based network achieved higher prediction accuracy and two-fold faster training times. We further tested the robustness and versatility of HAPPY-based network with an augmented training dataset. Additionally, we present topo-HAPPY (Topological HAPPY), an extension that incorporates topological details of the constituent connectivity, leading to improved solubility and glass transition temperature prediction accuracy.
Genome-wide Scan for Selection Signatures Using Tajima’s D and Pooled Heterozygosity in Ankamali Pigs of Kerala State, India
Authors: Roy Michelle Elezabeth , Manoj M , Sadan Tina , Rojan P.M , Aravindakshan T.V. , Usha A.P. , Unnikrishnan M.P. 
Published: September 2023

Abstract
Ankamali pig, a domesticated native variety is found in several parts of Kerala. They are well known for their disease resistance, lean meat and adaptability to hot and humid environmental conditions. Natural and artificial selection over a period of time left unique footprints (selection signatures) in genome resulting in dramatic changes in the phenotype of animals. Detection of artificial selection footprints in genomic regions can provide insights for understanding the function of specific phenotypic traits and better guide animal breeding. The present study is aimed to explore, genome-wide scanning using whole genome sequencing to detect selection signatures and enrichment analysis of selective sweep regions. Genomic DNA was isolated from 12 pigs and pooled after quality checks for WGS. Selective sweep regions were identified by using Tajima’s D (TD) and pooled heterozygosity (Hp) statistics. A total of 437 and 484 selective signals were obtained (with a threshold of –ZTD < -2.32 and -ZHp < -2.32) and more than 600 potential genes were annotated. Several candidate genes associated with body size (PKPD1, MSTN), fertility (INHBB, CSMD1), erythrocyte stability (GYPC) and lipid metabolism (REPIN1) were identified. Gene ontology (GO) terms, including biological process (BP), cellular component and molecular function and KEGG pathway enrichment analyses were conducted. Two hundred sixty-eight enriched GO terms were found in the present study. In KEGG analysis, nine and more than 30 enriched pathways were found using Tajima’s D and pooled Heterozygosity respectively, with herpes simplex infection being the most enriched, followed by Neurotrophin signalling pathway, m TOR signalling pathway etc.
Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth
Authors: Chang Yan-Zhong , Zuo Yong , Bai Jiawei , Bai Huiyuan , Tian Siyu , Sun Hongtao , Shi Zhenhua , Yu Peng , Gao Guofen , Li Yuan 
Published: September 2023

Abstract

Transmembrane serine protease 6 (Tmprss6) has been correlated with the occurrence and progression of tumors, but any specific molecular mechanism linking the enzyme to oncogenesis has remained elusive thus far. In the present study, we found that Tmprss6 markedly inhibited mouse neuroblastoma N2a (neuro-2a) cell proliferation and tumor growth in nude mice. Tmprss6 inhibits Smad1/5/8 phosphorylation by cleaving the bone morphogenetic protein (BMP) co-receptor, hemojuvelin (HJV). Ordinarily, phosphorylated Smad1/5/8 binds to Smad4 for nuclear translocation, which stimulates the expression of hepcidin, ultimately decreasing the export of iron through ferroportin 1 (FPN1). The decrease in cellular iron levels in neuro-2a cells with elevated Tmprss6 expression limited the availability of the metal forribo nucleotide reductase (RNR) activity, thereby arresting the cell cycle prior to S phase. Interestingly, Smad4 promoted nuclear translocation of activating transcription factor 3 (ATF3) to activate the p38 mitogen-activated protein kinases signaling pathway by binding to ATF3, inducing apoptosis of neuro-2a cells and inhibiting tumor growth. Disruption of ATF3 expressing significantly decreased apoptosis in Tmprss6 overexpressed neuro-2a cells. Our study describes a mechanism whereby Tmprss6 regulates the cell cycle and apoptosis. Thus, we propose Tmprss6 as a candidate target for inhibiting neuronal tumor growth.
Surrogacy of one-year survival for overall survival in advanced hepatocellular carcinoma
Authors: Jin yuzhi , Yue Qianhua , Wu Wei , Liu Chuan , Ren Hui , Guo Yixuan , Zhao Peng 
Published: September 2023

Abstract
Background
The increasing number of sequential treatments complicates the evaluation of overall survival (OS) in clinical trials for hepatocellular carcinoma (HCC), therefore, reliable surrogate endpoints (SEs) are required. This study aimed to evaluate the surrogacy of progression-free survival (PFS) and one-year (1-yr) milestone survival for OS in HCC trials.
Methods
We systematically searched databases for randomized clinical trials that evaluated systemic treatments for advanced HCC. Individual patient data were reconstructed to calculate the 1-yr survival rate. We adopted a two-stage meta-analytic validation model to evaluate the correlation between SEs and OS, and the correlation between treatment effects on SEs and OS. The hazard ratio (HR) was calculated to assess the treatment effects on PFS and OS, and the 1-yr survival ratio was calculated to evaluate the treatment effects on the 1-yr milestone survival.
Results
Thirty-two HCC trials involving 13,808 patients were included. A weak correlation was detected between the median PFS and median OS (R2 = 0.32), whereas the correlation improved between PFS HR and OS HR (R2 = 0.58). We identified strong correlations between the 1-yr survival rate and median OS and between the 1-yr survival ratio and OS HR (R2 = 0.74 and 0.65, respectively). In subgroup analyses, PFS HR strongly correlated with OS HR in trials relevant to immune checkpoint inhibitors (ICIs). Although the correlation remained weak between PFS and OS even in trials with PFS HR ≤ 0.6, the 1-yr survival rate and 1-yr survival ratio were strong surrogates for median OS and OS HR, respectively (R2 = 0.77 and 0.75).
Conclusions
One-year milestone survival outperformed PFS as a SE for OS in HCC, indicating the application of 1-yr survival as a secondary endpoint. In particular, PFS HR was a potential SE for OS HR in the ICI trials.
Psychosocial Care for Infants, Children and Adolescents with Variations of Sex Characteristics: Results from a Pan-European Survey
Authors: Gramc Martin , Stephenson John , Monro Surya , Streuli Jürg 
Published: September 2023

Abstract
Background
The Chicago Consensus statement introduced multidisciplinary care, psychosocial support and peer support for minors with variations of sex characteristics (VSC) and their parents. However, there is a lack of data on the provision and implementation of psychosocial support. This study addresses the gap in the knowledge on the type and timing of psychosocial support for minors with VSC and their families. It examines the provision of peer support, and compares perceptions of the level of implementation of psychosocial support among the participating HCPs and peer support group members. Perceptions of the obstacles to fuller provision of psychosocial care and peer support are also discussed.
Methods
A survey was conducted based on snowball purposive sample of healthcare professionals and members of peer support groups across Europe. 301 responses were received and analysed using descriptive and inferential methods.
Results
Regarding the current and aspired practice of different types of psychosocial care, almost all respondents considered psychosocial support to be needed. The most common features of current practice included discussing diagnostic procedures (86 respondents; 69.4%), with similar frequencies and proportions of general emotional support, discussing terminology and discussing medical treatment. In relation to the timing, the moment of the healthcare practitioner suspecting a variation of sex characteristics/Disorders or Differences of Sex Development (VSC/DSD) diagnosis was the aspired, but not currently achieved, point of implementation of psychosocial support; aspired to by 84 respondents (67.2%), but current practice for only 33 (26.4%). Inferential analysis showed significant differences in the perceived level of implementation of psychosocial support between healthcare professionals and peer support providers (p < 0.001 for all anticipated points of implementation of psychosocial support.) Parental distress and lack of training appeared to be the most difficult challenges faced by medical professionals.
Conclusions
The survey shows that psychosocial support and collaboration between healthcare providers and peer support groups have been insufficiently implemented, yet the need remains high. As early non-vital medical interventions carry a high risk of poor outcomes and parental distress, psychosocial support should be provided at the earliest point, when VSC are suspected or diagnosed. Follow-up studies should implement and assess the indicators for provision of psychosocial support and health care.
Survey of the national clinical practice of inhaled nitric oxide in preterm infants in China
Authors: Ke Tian , Lingyue Gong , Jun Tang , Yi Huang 
Published: September 2023

Abstract
Background
To help understand the current clinical practice and provide a reference for the quality improvement of iNO in preterm infants in China.
Methods
A survey on iNO use in preterm infants in neonatal intensive care units was sent to healthcare providers and conducted from January to February 2021.
Results
Of 678 people participated in this survey, 638 were finally included in the analysis. There was no statistical difference (P > 0.05) in iNO use in infants with a gestational age of 28–36 weeks among different types of hospitals; however, iNO use significantly differed in infants with a gestational age of < 28 weeks (P < 0.001). The younger the gestational age of preterm infants, the fewer the respondents who agreed with its use, with only 26.15% of respondents choosing to use iNO in neonates with a gestational age of < 28 weeks. Hypoxic respiratory failure combined with persistent pulmonary hypertension was the main indication for iNO. The majority of investigators (70.77%) used 20 ppm as the initial concentration of iNO therapy in preterm infants.
Conclusion
iNO has been used on preterm infants in some hospitals in China. High-quality clinical evidence is needed to further evaluate the dose, procedure, effectiveness, and safety of iNO in preterm infants.
Factors Determining Intimate Partner Violence (IPV) Among Married Women in Bhutan
Authors: Jamtsho Cheda 
Published: September 2023

Abstract
Background
Although continuous efforts are being made to address violence against women, the prevalence among married women and the underlying determining factors remain relatively underexplored and rarely studied in Bhutan. This study aims to determine the factors associated with IPV (physical, psychological or sexual), and to determine its prevalence, including women justifying IPV in Bhutan.
Methods
The study employed descriptive and multivariate logistic regression analyses, utilizing data from the 2010 Bhutan Multiple Indicator Survey, encompassing a sample of 9,210 married Bhutanese women.
Results
The prevalence of IPV was 22.5% (physical violence–12.8%; psychological violence–16.7%; and sexual violence–6.6%). The percentage of women who justified attitudes supporting wife hitting or beating was 71.2%. There was a negative association observed between household standard of living and physical, psychological and sexual IPV, as well as attitudes justifying IPV. Women residing in urban area was positively associated with physical but not with psychological domestic violence and an attitude about wife beating. Women’s age at first marriage was positively associated with physical and with attitudes about wife beating. Pregnant women exhibited reduced likelihood of experiencing both physical and psychological IPV, but pregnant women residing in rural areas faced higher odds of encountering both forms of IPV. Women who reported their husbands' infidelity exhibited elevated odds of experiencing both physical and psychological IPV.
Conclusion
Close to a quarter of married women have encountered IPV, with psychological IPV emerging as the most prevalent form, trailed by physical IPV. Household standard of living, lower education level, rural pregnancy, husband’s infidelity, area of residence, location, and women’s age at first marriage was risk factors of IPV.