bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acrylamide‐Sodium Vinyl Sulfonate Copolymers as Scale Inhibitor: Influence of Composition, Molar Mass and Chemical Modification
Authors: Celestino Gustavo G. , dos Santos Marcele C. , de Oliveira Luise S. S. , Santos Emanuela N. , de Oliveira Myllena B. , da Silva Luana S. , Lucas Elizabete F. 
Published: February 2025

ABSTRACTThe injection of seawater into petroleum reservoirs is employed to increase production. However, since seawater is rich in sulfate ions and connate water is rich in calcium, strontium, and barium ions, this mixture leads to the formation of insoluble salts, which form deposits that can block pipelines and damage pumps and valves. Chemical additives are used to prevent the formation of these deposits. However, there are still conditions in which commercial additives are not effective, justifying the investigation of different structures with the potential to inhibit inorganic fouling. Thus, we evaluate the influence of the composition, molar mass, and chemical modification (by insertion of phosphonic groups) of an acrylamide and sodium vinyl sulfonate (AC:VS) copolymer on the efficiency of inhibiting sulfate scaling. The materials are characterized in terms of structure, molar mass, and thermal stability. The following AC:VS compositions are obtained: 88:12, 75:25, 57:43, and 39:61. All copolymers are thermally stable and compatible with calcium ions. In general, AC:VS copolymers have similar performance (dynamic scale looping) to the commercial reference, and their chemical modification improves their performances. Morphological analyses indicate that the copolymers with high efficiency modify the crystal surface, forming asymmetric crystals that are less adherent.
Intercalating PANI Nanoparticles Into Ti3C2Tx MXene Fiber to Construct Open Ion Diffusion Channels for High‐Performance Flexible One Dimensional Supercapacitors
Authors: Zhang Yang , Wang Yusen , Qi Kangxin , Xu Jian , Zhang Shenao , Pi Xiangxiang , Gu Diwei , Sun Bin , Lu Wangyang 
Published: February 2025

ABSTRACTOwing to the high conductivity, abundant active sites, and large packing density, two‐dimensional materials Ti3C2Tx MXene flakes serve as a promising material to assemble flexible electrode for wearable electronics system. However, the intrinsic self‐restacking feature of two‐dimensional material still remains a pivotal issue that impedes fascinating electrochemical performance. Here, we assemble a flexible fiber‐shaped supercapacitor (F‐SC) based on polyaniline (PANI) hybridized Ti3C2Tx (PT) fiber using a wet spinning process. The existence of PANI nanoparticles between the two‐dimensional sheets can enhance the layer distance significantly and restrain the layer restacking effect, leading to a large surface area, good ion diffusion kinetics, and rich adsorption sites. Additionally, PANI can effectively create a stable interface interaction between adjacent Ti3C2Tx fiber, constructing smooth electron migration pathways. As a result, the PT fiber presents excellent specific capacitance (200.7 F g−1 at 1 A g−1) and rate performance (86.5 F g−1 at 10 A g−1). Notably, the fabricated symmetric F‐SC appears to have a favorable energy density of 2.5 Wh kg−1, considerable mass capacitance of 88.7 F g−1 at 0.1 A g−1 and good mechanical endurance (bending 180o), which shows a bright future in wearable application.
Extended Maternity Leave and Female Labour Supply: Evidence From a Regional Policy in China
Authors: Hu Mingzhi , Su Yinxin 
Published: February 2025

ABSTRACTMaternity leave for women has been substantially extended in China since the 2016 maternity leave reform, but maternity leave length varies greatly across regions. On the one hand, women are more likely to engage in employment due to extended maternity leave. On the other hand, extended maternity leave can increase the discrimination against women in the labour market and force them to enter into entrepreneurship. Exploiting the 2016 maternity leave reform as an exogenous change in maternity leave for women and employing a difference‐in‐differences framework, this study examines the effect of extended maternity leave on female labour force participation. Using data from the China Migrants Dynamic Survey, we find that the maternity leave reform leads to an increase in entrepreneurship rate (employment rate) by 4.74 (1.76) percentage points for women without children, whereas this effect is insignificant for women with children and old women.
Genetically Engineered Bacteria as a Promising Therapeutic Strategy Against Cancer: A Comprehensive Review
Authors: Zahedifard Zahra , Mahmoodi Shirin , Ghasemian Abdolmajid 
Published: February 2025

ABSTRACTAs a significant cause of global mortality, the cancer has also economic impacts. In the era of cancer therapy, mitigating side effects and costs and overcoming drug resistance is crucial. Microbial species can grow inside the tumor microenvironment and inhibit cancer growth through direct killing of tumor cells and immunoregulatory effects. Although microbiota or their products have demonstrated anticancer effects, the possibility of acting as pathogens and exerting side effects in certain individuals is a risk. Hence, several genetically modified/engineered bacteria (GEB) have been developed to this aim with ability of diagnosing and selective targeting and destruction of cancers. Additionally, GEB are expected to be considerably more efficient, safer, more permeable, less costly, and less invasive theranostic approaches compared to wild types. Potential GEB strains such as Escherichia coli (Nissle 1917, and MG1655), Salmonella typhimurium YB1 SL7207 (aroA gene deletion), VNP20009 (∆msbB/∆purI) and ΔppGpp (PTet and PBAD), and Listeria monocytogenes Lmat‐LLO have been developed to combat cancer cells. When used in tandem with conventional treatments, GEB substantially improve the efficacy of anticancer therapy outcomes. In addition, public acceptance, optimal timing (s), duration (s), dose (s), and strains identification, interactions with other strains and the host cells, efficacy, safety and quality, and potential risks and ethical dilemmas include major challenges.
trans‐Ferulic Acid Antagonizes the Anti‐Inflammatory Activity of Etoricoxib: Possible Interaction of COX‐1 and NOS
Authors: Bhuia Md. Shimul , Chowdhury Raihan , Hasan Rubel , Hasan Md. Sakib Al , Ansari Siddique Akber , Ansari Irfan Aamer , Mubarak Mohammad S. , Coutinho Henrique D. M. , Domiciano Carolina Bandeira , Islam Muhammad Torequl 
Published: February 2025

ABSTRACTThis study emphasizes to investigate the modulatory activity of trans‐ferulic acid (TFA) on anti‐inflammatory activity of etoricoxib (ETO) and underlying mechanisms via formalin‐induced licking and paw edema model and in silico study. Inflammation was induced by injecting formalin (50 µL) into the right hind paw of mice. The animals were treated with different doses of TFA (25, 50, and 75 mg/kg, p.o.). The vehicle and ETO (35 mg/kg, p.o.) were provided as positive and negative control, respectively. ETO also served combined with TFA to evaluate the modulatory activity. The licking behavior was counted for the early and late phases, whereas the paw edema diameter was measured by using a slide caliper. All treatment was continued for 7 days until the edema was totally minimized to determine the inflammation's recovery capability for a specific group. Different computed and web tools were used to estimate molecular binding affinity, binding interactions, and pharmacokinetics. The findings demonstrated that TFA significantly (p < 0.05) enhanced the onset of licking and reduced the number of licks compared to vehicle group. TFA also showed a significant (p < 0.05) diminished in paw edema and complete recovered of the edema after 5 days of treatment indicating the anti‐inflammatory effects. However, TFA with ETO notably diminished the anti‐inflammatory effects of ETO by enhancing paw edema diameter and licking number. TFA also expressed elevated binding affinity of −7.5 and −6.5 kcal/mol toward nitric oxide (NO) synthase and COX‐1, respectively. In conclusion, TFA exerted anti‐inflammatory effects and reduces anti‐inflammatory capability of ETO.
Improving Clothing and Grooming Appearance of Students With Neurodevelopmental Disabilities: Evaluation of a Measurement Checklist and Care Provider Intervention
Authors: Buckley Jessica , Brodeur Jessica , Clark Melissa , Bird Frank , Luiselli James K. 
Published: February 2025

ABSTRACTThere is limited research concerned with the physical appearance of persons who have intellectual and developmental disabilities. This study evaluated a clothing and grooming measurement checklist and care provider intervention to improve the physical appearance of four students (18‐ to 21‐years‐old) with neurodevelopmental disabilities. The measurement checklist was easy to administer, time‐efficient, and associated with good interobserver agreement (IOA). Implemented in a multiple baseline design, the care provider intervention had an immediate and sustained positive effect with all students. We discuss measurement and intervention considerations, outcome objectives, and research directed at physical appearance among dependent populations.
Navigating the AQbD Landscape: Enhancing Quality Management in Liquid Chromatography Method Development
Authors: Kanthiah Selvakumar , Joysa Ruby J. , SGB Hiriyanna , Kannappan Valliappan 
Published: February 2025

ABSTRACTThe implementation of ‘Analytical Quality by Design’ (AQbD) is currently recognised as a methodical and scientific approach to liquid chromatographic (LC) method development. It begins with defining the Analytical Target Profile (ATP), identifying Critical Method Parameters (CMPs) and Critical Quality Attributes (CQAs) or responses. This process also includes risk assessment study by Design of Experiment (DoE) and to optimise LC effectively. The next step is to create an analytical design space and implement a control strategy that will allow for continuous method improvement over the life of the method. Understanding the AQbD principles, methodologies, techniques and applications towards the high‐performance liquid chromatography (HPLC) method lifecycle is considered as essential in today's pharmaceutical landscape. As industry demands for quality assurance and regulatory compliance, this review paper briefly discusses the AQbD principles and methodology in HPLC method lifecycle. Also, the paper covers AQbD components such as identification of ATP, CQA, MODR (method operable design region), control strategies and continuous method monitoring. In addition, it also covers regulatory perspectives on AQbD, obstacles and potential outcomes in the development of pharmaceutical analytical methods. These aspects provide valuable insights into the application of AQbD in the field of LC.
Analyzing and Predicting the Relationship Between the Coupling Capacitance and the Plates Misalignment Based on SSA‐CNN Method in Dynamic Charging of EVs
Authors: Li Shenwang , Wu Songjian , Su Qiuren , Chen Junkuan , Wu Thomas Xinzhang 
Published: February 2025

ABSTRACTElectric vehicles (EVs) have become increasingly popular among new energy vehicles. Therefore, the cost of charging devices and the efficiency of power conversion are major challenges to the large‐scale development of EVs. Capacitive power transfer (CPT) technology uses an electric field for transmission, which is low‐cost and insensitive to metal objects. Usually, the vehicle chassis is made of metal. It is relatively easy to deal with the chassis when we use CPT. To analyze and predict the relationship between the four‐plate capacitive coupler (FPCC) lateral and longitudinal misalignment, vertical distance variation, and the coupling capacitance, a prediction model of the coupling capacitance is proposed, based on the Sparrow Search Algorithm optimized convolutional neural network (SSA‐CNN). Firstly, replace the four‐plate coupling structure with the six‐capacitor model, derive the π‐shape model based on Kirchhoff's current equation, and transform the π‐shape model into the T‐shape model through the star‐delta transformation method. Next, the coupling capacitances for the plates misalignment are simulated utilizing Maxwell. Finally, through theoretical analysis and experimental validation, it is demonstrated that the proposed prediction model in this paper can predict the relationship between CN and the plates dynamic misalignment within a 15% error in the given range.
Segmentation of IC Images in Integrated Circuit Reverse Engineering Using EfficientNet Encoder Based on U‐Net++ Architecture
Authors: Cheng Hongnan , Yu Chaozhi , Zhang Chenguang 
Published: February 2025

ABSTRACTSegmentation of electrical components and metal traces from integrated circuit (IC) images is crucial for IC reverse engineering. Existing image segmentation methods face significant challenges when applied to IC images, including high resolution, limited training data, and the need for precise segmentation. To address these issues, this study proposes a combined approach of segmentation and post‐processing. During the segmentation stage, we use UNet++ as the base architecture, with EfficientNet‐B7 as the encoder, resulting in an E‐UNet++ model. This model effectively combines the efficiency and pre‐training capabilities of EfficientNet with the ability of UNet++ to capture both global structural information and fine‐grained boundary details in IC images, enabling it to effectively handle challenges such as high resolution and limited training samples. In the post‐processing stage, to address potential noise caused by the insufficient utilization of spatial location information in network‐based methods, we propose the use of Hough circle detection and median filtering to eliminate noise from vias and non‐via regions. Compared to the suboptimal segmentation model, our proposed method achieved a 0.58% improvement in mean intersection over union (mIoU) and a 0.33% improvement in mean pixel accuracy (MPA) on the real‐world dataset and a 0.78% improvement in mIoU and a 0.44% improvement in MPA on the open‐source dataset. These experimental results demonstrate that our method effectively improves the accuracy of IC segmentation.
Ubiquitin‐specific protease 25 improves myocardial ischemia–reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes
Authors: Ye Bozhi , Xu Diyun , Zhong Lingfeng , Wang Yi , Wang Wei , Xu Haowen , Han Xue , Min Julian , Wu Gaojun , Huang Wenhai , Liang Guang 
Published: February 2025

AbstractBackgroundMyocardial ischemia/reperfusion injury (MI/RI) restricts the effect of myocardial reperfusion therapy and lacks effective prevention and treatment methods. Deubiquitinating enzymes (DUBs), especially members of the ubiquitin‐specific protease (USP) family of DUBs, are key proteins in the ubiquitination modification process and play a vital role in MI/RI. Therefore, we aimed to investigate the role of USP25, as a member of the USP family, in MI/RI and its molecular mechanism.MethodsTranscriptome sequencing was applied to evaluate the differential expression of USP families during hypoxia/reoxygenation (H/R) and validated in human and mouse heart samples and cardiomyocytes by performing quantitative polymerase chain reaction. Wild‐type or USP25−/− mice were used to develop the MI/RI model. Co‐immunoprecipitation (Co‐IP) combined with liquid chromatography–tandem mass spectrometry analysis was used to screen the potential substrate protein of USP25 in H/R‐induced cardiomyocyte injury. TUNEL and Hoechst/propidium iodide staining and western blot were used to detect the level of pyroptosis. In addition, cardiomyocyte‐specific USP25 overexpression in NLRP3−/− mice with AAV9 vectors was used to validate the biological function of USP25 and NLRP3 interaction.ResultsWe found that the expression level of USP25 was significantly decreased in I/R‐induced mouse heart tissues and primary cardiomyocytes in a time‐dependent manner. USP25 deficiency exacerbated MI/RI and aggravated I/R‐induced cardiac remodelling in mice. Mechanistically, USP25 directly binds to NLRP3 protein and K63‐linkedly deubiquitinates NLRP3 at residue K243 via its active site C178, thus hindering NLRP3–ASC interaction and ASC oligomerization to inhibit NLRP3 activation and pyroptosis in cardiomyocytes. We further showed that the overexpression of USP25 in cardiomyocytes ameliorated MI/RI in mice, whereas this protective effect disappeared when NLRP3 is knocked out.ConclusionsOur study demonstrated that USP25 ameliorates MI/RI by regulating NLRP3 activation and its mediated pyroptosis. This finding extends the protective role of USP25 in cardiovascular disease and provides an experimental basis for future USP25‐based drug development for the treatment of MI/RI.Key points
The deubiquitinating enzyme USP25 was down‐regulated both in myocardial ischemia/reperfusion injury (MI/RI) myocardium tissues.
The deficiency of USP25 worsened exacerbated MI/RI in mice, whereas the overexpression of USP25 in cardiomyocytes mitigated this pathological phenotype.
USP25 directly interacts with the NLRP3 protein and deubiquitinates it via K63 linkage at residue K243 through its active site C178, thus affecting NLRP3‐ASC interaction and ASC oligomerization to inhibit NLRP3 activation and pyroptosis in cardiomyocytes.
A novel construction approach for the pore structure model principally focuses on the controllable roundness of rock particles
Authors: Dong Jiabin , Yang Ning , Jin Yi , Wu Ying , Liu Dandan , Zheng Junling , Zhao Jingyan 
Published: February 2025

AbstractPores among particles provide the main space for the storage and migration of deep underground fluids (such as oil, gas, groundwater, and unconventional natural gas). The pores form a pore structure with complex morphology which is mainly dominated by the shape and distribution of particles. Therefore, the reconstruction of the pore structure or granular porous media and the evaluation of particle roundness have become an important foundation for the study of fluid flow through deep underground rock mass. This research proposes a novel approach for the multi‐scale model with angular vertexes. The fractal topology theory and Voronoi space segmentation technology are combinedly used for the reconstruction of fractal granular porous media. The angular shapes are smoothed by using a modified B‐spline technique and the particles with varying degrees of roundness are generated. To validate the superiority of our approach, the roundness based on the Wadell roundness calculation method is calculated and compared with the roundness obtained from particles smoothed using the vertex rounding substitution method. Results show that the roundness of particles smoothed with the modified B‐spline technique closely aligns with the corresponding set rounded level (a nondimensional variable). Conversely, the vertex rounding substitution method is limited to a single dimensionally rounded radius. This innovative approach can offer a new method for the construction of granular porous media for the fluid flow study in deep underground rock mass.
Heterogeneity of Locked‐Pasture Snow Conditions Modulate Habitat and Movement Choices of a Facultative Migrant
Authors: Gura Katherine B. , Liston Glen E. , Reinking Adele K. , Bedrosian Bryan , Elder Kelly , Chalfoun Anna D. 
Published: February 2025

ABSTRACTHabitat selection and movement are key mechanisms by which animals can respond to and potentially cope with highly variable environmental conditions. Optimal responses likely vary, however, depending on the severity and scope of conditions. We tested this hypothesis using a facultative migrant species, the Great Gray Owl (Strix nebulosa), which exhibits high inter‐ and intra‐individual variation in the timing, direction, and distance of winter movements. Specifically, we evaluated whether episodic, spatiotemporally variable “locked‐pasture” snow conditions, which restrict access to subnivean food, prompted shifts in habitat selection or long‐distance movements by owls. We quantified the movement of 42 owls using global positioning system (GPS) data within the Greater Yellowstone Ecosystem, USA, during 2017–2022. We used a novel ecological application of SnowModel, a snow evolution modeling system, to estimate fine‐scale, physical snow properties likely to influence access to prey. Variables included snow depth, snow crusts produced by wind, and ice crusts produced by melt‐freeze and rain‐on‐snow events. Owls avoided heterogeneously distributed wind crusts via local shifts in habitat selection. More homogenous ice crusts elicited long‐distance movements away from affected home ranges. Finally, owls employed both proximate shifts in habitat selection and long‐distance movements to avoid deeper snow. Ultimately, owls exhibited behavioral flexibility in response to limiting snow conditions that can vary in terms of severity, spatial extent, and duration. Such behavioral responses determine species distribution, with implications for population and community dynamics in spatiotemporally variable systems. Understanding the effects of, and responses to, environmental controls is increasingly important given the scope of on‐going global change.
The Efficacy and Safety of Botulinum Neurotoxin Type A in Treating Chronic Low Back Pain: A Systematic Review, Meta‐Analysis, Trial Sequential Analysis, and Meta‐Regression
Authors: Wagrees Waseem , Kelani Hesham , Salamah Hazem Mohamed , Mahmoud Abdelrahman , Khlidj Yehya , Abdelraouf Mohamed R. , Sharaf Bahaa , Elnewishy Moustafa , Albaramony Nadia , Naeem Ahmed , Elazim Ahmed Abd , El‐Ghanem Mohammad , Greene‐Chandos Diana , Jadidi Mohammad , Lerner David P. , Kay Arthur D. , Merlin Lisa R. , Brock Charles 
Published: February 2025

ABSTRACTBackgroundChronic low back pain (CLBP) is a leading cause of disability. Botulinum neurotoxin type A (BoNT‐A) has strong anti‐spasmodic and analgesic effects, suggesting that its local muscular injection can reduce CLBP compared to other therapies. In this systematic review and meta‐analysis, we investigated the efficacy and safety of BoNT‐A on patients with CLBP.MethodsWe searched PubMed, Scopus, Cochrane, and Web of Science databases for studies comparing BoNT‐A to other therapies in terms of functional improvement and pain improvement as measured by visual analog scale (VAS) and clinically significant improvement in pain (50% or greater reduction in VAS score). We employed trial sequential analysis (TSA) to confirm the findings. The GRADE approach was employed to assess the overall quality of the evidence.ResultsThe search yielded nine studies, seven randomised clinical trials (RCTs), and two prospective observational studies. Compared to the control, BoNT‐A increased the incidence of clinically significant improvement in pain (RR = 4.82, 95% CI (3.00, 7.76), p < 0.00001) and functional improvement (RR = 3.81, 95% CI (2.40, 6.04), p < 0.00001) (low‐certainty evidence), and reduced VAS score (MD = −1.62, 95% CI (−3.13, −0.11), p = 0.04) (very low‐certainty evidence). Subgroup analysis showed that BoNT‐A is effective against normal saline (moderate‐certainty evidence), and it was comparable to steroids and local anaesthetics (very low‐certainty evidence). TSA confirmed the findings regarding clinical improvement in pain and functional improvement.ConclusionBoNT‐A is a tolerable and effective treatment for CLBP with a longer duration of action. Future high‐quality studies are needed to confirm our findings.SignificanceThis paper provides good evidence that BoNT‐A may be employed in patients suffering from resistant chronic low back pain not responding to normal saline injection due to its higher efficacy and longer duration of action. Compared to steroids and local anaesthetics injections, there is not enough data to draw a firm conclusion and future studies are needed.