bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evil is still evidence: comment on Almeida
Authors: Bass Robert 
Published: May 2023

AbstractMichael Almeida has recently tried to show that if S5 correctly represents metaphysical necessity, there can be no non-trivial evidence for or against the existence of the traditional God. Evidence would thus be irrelevant to the reasonability of traditional theistic belief. Almeida's argument has implications beyond its announced target: it amounts to a new argument for sweeping scepticism. Almeida's argument for the irrelevance of evidence to the existence of God would apply to any state of affairs that entails some metaphysical necessity. In S5, every state of affairs entails some metaphysical necessity, so Almeida should conclude that non-trivial evidence for or against any state of affairs is impossible. I argue that the problem is not with S5 but with inadequately motivated assumptions about evidential support. Avoiding those assumptions disables the argument for sweeping scepticism and without foreclosing the possibility of non-trivial evidence for or against the existence of the traditional God.
Sacred groves: a model of Zagros forests for carbon sequestration and climate change mitigation
Authors: Moradi Aioub , Shabanian Naghi 
Published: May 2023

SummaryForests are the most important carbon pools among terrestrial ecosystems, and ensuring less disturbance of sacred groves might constitute a form of forest management for carbon sequestration and climate change reduction. The carbon contents in Zagros oak sacred groves and silvopastoral lands were compared to determine the carbon sequestration potential of these forests. Using a nested sampling design, we measured total carbon content (tC ha–1; aboveground tree biomass, aboveground sapling biomass, belowground biomass, soil organic carbon, leaf litter, herbs and grasses and dead wood and fallen stumps) in both forest groves and silvopastoral lands. The mean total biomass and mean total carbon content varied between sacred groves (453.8 t ha–1and 338.79 tC ha–1, respectively) and silvopastoral lands (89.4 t ha–1and 113.46 tC ha–1, respectively). Mean soil organic carbon was significantly lower (71.44 tC ha–1) in silvopastoral lands than in sacred groves (125.49 tC ha–1). The mean total sequestered carbon dioxide (CO2) was 1243.36 tCO2ha–1in the sacred groves and 416.40 tCO2ha–1in silvopastoral lands. We conclude that human activities have reduced the CO2absorption capacity of the forests. The substantial disparities between the landscapes emphasize the need to restore damaged forests, and sacred groves might be a useful model for increasing carbon storage in these forests.
AEPC recommendations for training in interventional catheterisation for CHD
Authors: Krasemann Thomas , Butera Gianfranco , Thomson John , Chessa Massimo , Bokenkamp Regina 
Published: May 2023

AbstractTo reflect new developments in imaging, indications, and techniques in catheterisation of patients with CHD, the training recommendations of the Association for European Paediatric and Congenital Cardiology (AEPC) for the training in interventional catheterisation for CHD have been reviewed and updated after more than 7 years. They include detailed information about knowledge, skills, and approach to clinical practice expected from trainees at basic, intermediate, and advanced level.
A clinical audit of patient safety in an Irish radiotherapy department
Authors: O’Sullivan K. , Lyons C. A 
Published: May 2023

Abstract

Introduction:
Radiotherapy is an ever-changing field with constant technological advances. It is for this reason that risk management strategies are regularly updated in order to remain optimal.

Methodology:
A retrospective audit of all reported incidents and near misses in the audited department between 1 November 2020 and 30 April 2021 was performed. The root cause of each radiotherapy error (RTE), safety barrier (SB) and the causative factor (CF) would be defined by the Public Health England (PHE) coding system. The data will then be analysed to determine if there are any frequently occurring errors and if there are any existing relationships between multiple error.

Results:
670 patients were treated during the study period along with 35 reports generated. 77·1% (n = 27) were incidents, and 22·9% (n = 8) were near misses. 2·8% (n = 1) were reportable incidents. The ratio of RTEs to prescriptions was 0·052:1 (5·2%). 37% of RTEs were associated with image production. Slips and lapses were involved in 54·2%. Adherence to procedures/protocols was a factor in 48·5% (n = 17). Communication was a factor in 11·4% (n = 4).

Discussion:
The proportion of Level 1 incidents was higher in this department (2·8%) than in the PHE report (0·9%). Almost one-third, 31·4% (n = 11) of errors stemmed from one technical fault in image production. SB breaches were prevalent at the pre-treatment planning stage of the pathway. A relationship between slips/lapses and non-conformance to protocols was identified.

Conclusion:
The rate of reported radiotherapy incidents in the UK is lower when compared with this department; this could be improved with the implementation of the quality improvement plan outlined above.
The Golden Age of Pragmatic Socialism: Wisconsin Socialists at the State Level, 1919–37
Authors: Kluever Joshua 
Published: May 2023

AbstractThroughout the 1920s and early 1930s, Socialists in Wisconsin experienced a “golden age” of political successes in the state legislature. Whereas the 1920s are commonly seen as a period of socialist decline, Wisconsin Socialists entered the decade with a renewed sense of optimism. Following World War I, the Wisconsin Democratic Party collapsed as a viable political option and the Wisconsin Socialist Party found itself the second most powerful party behind the Republican Party. Wisconsin Socialists took a pragmatic approach to legislative debates and allied with progressive Republicans to defeat conservative opposition. Socialists were vital to progressive reform prior to World War I; however, the Socialist-Progressive alliance reached its full potential in the 1920s. From 1919–31, the Wisconsin legislature passed 295 Socialist-authored pieces of legislation ranging from labor demands, public utilities, and criminal justice reform. Many of the proposals resulted from negotiations between the Socialist and Progressive caucuses. The success of the Wisconsin Socialists—and their alliance with progressive Republicans—suggests that at least in some places the Progressive Era extended into the 1920s.
Lightning VHF Radiation Mapping Method for an Irregular Short‐Baseline Array
Authors: Yuan Shanfeng , Qie Xiushu , Jiang Rubin , Sun Zhuling , Li Fengquan , Yang Jing 
Published: May 2023

AbstractLightning very high frequency interferometry is a crucial tool for studying the development of lightning leaders within thunderclouds, and the conventional antenna array is composed of two coplanar orthogonal baselines. In this study, we develop two new location methods for an irregular array based on the optimization algorithm, using all baselines in the calculation. Besides, we have analyzed the effects of two kinds of time uncertainty on the location result and provided a calibration method. The first type—the systematic time drift of antennas—can induce an offset on the location result, leading to a worse accuracy. We can calibrate the time drift of each antenna efficiently during the experiment. The second type—the waveform distortion between different antennas—can introduce the noise on time, leading to worse precision. The location precision improves when more baselines are used, whether they are independent or redundant. Our result shows that the non‐coplanar configuration can significantly improve the elevation uncertainty near the horizon and the azimuth uncertainty near the zenith after considering the angular uncertainty's theoretical distribution.
Titanite Petrochronology Records Secular Temperature and Fluid Evolution During Ductile Deformation: An Example From Late Cretaceous Shear Zones in the Eastern Transverse Ranges
Authors: Moser Amy C. , Lusk Alexander D. , Attia Snir , Garber Joshua M. , Seward Gareth G. E. , Kylander‐Clark Andrew R. C. 
Published: May 2023

AbstractQuantifying the timing and conditions of ductile deformation is essential for quantitative models of lithospheric deformation. Yet, directly constraining these variables and documenting how they change during a single deformation event remain difficult. We present titanite microstructural, zoning, trace‐element, and U‐Pb data from <m‐scale mylonitic shear zones in the Eastern Transverse Ranges, CA (Joshua Tree National Park) that record (a) the timing and conditions of ductile deformation and (b) the evolution of deformation conditions within a single, punctuated ductile deformation event. Titanite grains in sheared plutonic rocks yield a bimodal distribution of dates (∼151 and ∼75 Ma) interpreted as the independently constrained pluton crystallization and shear zone deformation ages, respectively. Synkinematic titanite neocrystallization at ∼75 Ma documents early deformation at ∼640–710°C under hydrous fluid conditions. Recrystallized titanite rims with ∼75 Ma dates indistinguishable from the neocrystallized titanite record Zr‐in‐titanite temperatures of 600–610°C and higher F contents, suggesting that the fluid became a more halogen‐rich brine as deformation progressed and the system cooled. Chemical zoning related to fluid‐driven recrystallization occurs in tandem with lattice misorientations and partially to fully reset U‐Pb dates in bent titanite, implying that reactive fluid flow is the ultimate mechanism by which dates are reset in titanite deformed by dislocation creep. These data document a punctuated (e.g., ∼1–3 Myr) phase of high‐temperature deformation that accompanied local pluton emplacement and demonstrate that titanite petrochronology can capture multiple, discrete reactions associated with crustal weakening and variables that affect the rheological evolution of ductile shear zones.
Mass Cytometry reveals unique phenotypic patterns associated with subclonal diversity and outcomes in multiple myeloma
Authors: Baughn Linda B. , Jessen Erik , Sharma Neeraj , Tang Hongwei , Smadbeck James B. , Long Mark D. , Pearce Kathryn , Smith Matthew , Dasari Surendra , Sachs Zohar , Linden Michael A. , Cook Joselle , Keith Stewart A. , Chesi Marta , Mitra Amit , Leif Bergsagel P. , Van Ness Brian , Kumar Shaji K. 
Published: May 2023

AbstractMultiple myeloma (MM) remains an incurable plasma cell (PC) malignancy. Although it is known that MM tumor cells display extensive intratumoral genetic heterogeneity, an integrated map of the tumor proteomic landscape has not been comprehensively evaluated. We evaluated 49 primary tumor samples from newly diagnosed or relapsed/refractory MM patients by mass cytometry (CyTOF) using 34 antibody targets to characterize the integrated landscape of single-cell cell surface and intracellular signaling proteins. We identified 13 phenotypic meta-clusters across all samples. The abundance of each phenotypic meta-cluster was compared to patient age, sex, treatment response, tumor genetic abnormalities and overall survival. Relative abundance of several of these phenotypic meta-clusters were associated with disease subtypes and clinical behavior. Increased abundance of phenotypic meta-cluster 1, characterized by elevated CD45 and reduced BCL-2 expression, was significantly associated with a favorable treatment response and improved overall survival independent of tumor genetic abnormalities or patient demographic variables. We validated this association using an unrelated gene expression dataset. This study represents the first, large-scale, single-cell protein atlas of primary MM tumors and demonstrates that subclonal protein profiling may be an important determinant of clinical behavior and outcome.
FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells
Authors: Zhang Fei , Wei Lei , Wang Lei , Wang Tao , Xie Zhihong , Luo Hong , Li Fanchao , Zhang Jian , Dong Wentao , Liu Gang , Kang Qinglin , Zhu Xuesong , Peng Wuxun 
Published: May 2023

AbstractThe specific pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH) is still not fully understood, and there is currently no effective early cure. Understanding the role and mechanism of long noncoding RNAs (lncRNAs) in the pathogenesis of SONFH will help reveal the pathogenesis of SONFH and provide new targets for its early prevention and treatment. In this study, we first confirmed that glucocorticoid (GC)-induced apoptosis of bone microvascular endothelial cells (BMECs) is a pre-event in the pathogenesis and progression of SONFH. Then, we identified a new lncRNA in BMECs via lncRNA/mRNA microarray, termed Fos-associated lincRNA ENSRNOT00000088059.1 (FAR591). FAR591 is highly expressed during GC-induced BMEC apoptosis and femoral head necrosis. Knockout of FAR591 effectively blocked the GC-induced apoptosis of BMECs, which then alleviated the damage of GCs to the femoral head microcirculation and inhibited the pathogenesis and progression of SONFH. In contrast, overexpression of FAR591 significantly promoted the GC-induced apoptosis of BMECs, which then aggravated the damage of GCs to the femoral head microcirculation and promoted the pathogenesis and progression of SONFH. Mechanistically, GCs activate the glucocorticoid receptor, which translocates to the nucleus and directly acts on the FAR591 gene promoter to induce FAR591 gene overexpression. Subsequently, FAR591 binds to the Fos gene promoter (–245∼–51) to form a stable RNA:DNA triplet structure and then recruits TATA-box binding protein associated factor 15 and RNA polymerase II to promote Fos expression through transcriptional activation. Fos activates the mitochondrial apoptotic pathway by regulating the expression of Bcl-2 interacting mediator of cell death (Bim) and P53 upregulated modulator of apoptosis (Puma) to mediate GC-induced apoptosis of BMECs, which leads to femoral head microcirculation dysfunction and femoral head necrosis. In conclusion, these results confirm the mechanistic link between lncRNAs and the pathogenesis of SONFH, which helps reveal the pathogenesis of SONFH and provides a new target for the early prevention and treatment of SONFH.
Allnighter pseudokinase-mediated feedback links proteostasis and sleep in Drosophila
Authors: Shekhar Shashank , Moehlman Andrew T. , Park Brenden , Ewnetu Michael , Tracy Charles , Titos Iris , Pawłowski Krzysztof , Tagliabracci Vincent S. , Krämer Helmut 
Published: May 2023

AbstractIn nervous systems, retrograde signals are key for organizing circuit activity and maintaining neuronal homeostasis. We identify the conserved Allnighter (Aln) pseudokinase as a cell non-autonomous regulator of proteostasis responses necessary for normal sleep and structural plasticity of Drosophila photoreceptors. In aln mutants exposed to extended ambient light, proteostasis is dysregulated and photoreceptors develop striking, but reversible, dysmorphology. The aln gene is widely expressed in different neurons, but not photoreceptors. However, secreted Aln protein is retrogradely endocytosed by photoreceptors. Inhibition of photoreceptor synaptic release reduces Aln levels in lamina neurons, consistent with secreted Aln acting in a feedback loop. In addition, aln mutants exhibit reduced night time sleep, providing a molecular link between dysregulated proteostasis and sleep, two characteristics of ageing and neurodegenerative diseases.
Direct conversion of lignin to functionalized diaryl ethers via oxidative cross-coupling
Authors: Liu Mingyang , Dyson Paul J. 
Published: May 2023

AbstractEfficient valorization of lignin, a sustainable source of functionalized aromatic products, would reduce dependence on fossil-derived feedstocks. Oxidative depolymerization is frequently applied to lignin to generate phenolic monomers. However, due to the instability of phenolic intermediates, repolymerization and dearylation reactions lead to low selectivity and product yields. Here, a highly efficient strategy to extract the aromatic monomers from lignin affording functionalized diaryl ethers using oxidative cross-coupling reactions is described, which overcomes the limitations of oxidative methods and affords high-value specialty chemicals. Reaction of phenylboronic acids with lignin converts the reactive phenolic intermediates into stable diaryl ether products in near-theoretical maximum yields (92% for beech lignin and 95% for poplar lignin based on the content of β−O−4 linkages). This strategy suppresses side reactions typically encountered in oxidative depolymerization reactions of lignin and provides a new approach for the direct transformation of lignin into valuable functionalized diaryl ethers, including key intermediates in pharmaceutical and natural product synthesis.
A method for restoring signals and revealing individual macromolecule states in cryo-ET, REST
Authors: Zhang Haonan , Li Yan , Liu Yanan , Li Dongyu , Wang Lin , Song Kai , Bao Keyan , Zhu Ping 
Published: May 2023

AbstractCryo-electron tomography (cryo-ET) is widely used to explore the 3D density of biomacromolecules. However, the heavy noise and missing wedge effect prevent directly visualizing and analyzing the 3D reconstructions. Here, we introduced REST, a deep learning strategy-based method to establish the relationship between low-quality and high-quality density and transfer the knowledge to restore signals in cryo-ET. Test results on the simulated and real cryo-ET datasets show that REST performs well in denoising and compensating the missing wedge information. The application in dynamic nucleosomes, presenting either in the form of individual particles or in the context of cryo-FIB nuclei section, indicates that REST has the capability to reveal different conformations of target macromolecules without subtomogram averaging. Moreover, REST noticeably improves the reliability of particle picking. These advantages enable REST to be a powerful tool for the straightforward interpretation of target macromolecules by visual inspection of the density and of a broad range of other applications in cryo-ET, such as segmentation, particle picking, and subtomogram averaging.
Functional specialization and interaction in the amygdala-hippocampus circuit during working memory processing
Authors: Li Jin , Cao Dan , Yu Shan , Xiao Xinyu , Imbach Lukas , Stieglitz Lennart , Sarnthein Johannes , Jiang Tianzi 
Published: May 2023

AbstractBoth the hippocampus and amygdala are involved in working memory (WM) processing. However, their specific role in WM is still an open question. Here, we simultaneously recorded intracranial EEG from the amygdala and hippocampus of epilepsy patients while performing a WM task, and compared their representation patterns during the encoding and maintenance periods. By combining multivariate representational analysis and connectivity analyses with machine learning methods, our results revealed a functional specialization of the amygdala-hippocampal circuit: The mnemonic representations in the amygdala were highly distinct and decreased from encoding to maintenance. The hippocampal representations, however, were more similar across different items but remained stable in the absence of the stimulus. WM encoding and maintenance were associated with bidirectional information flow between the amygdala and the hippocampus in low-frequency bands (1–40 Hz). Furthermore, the decoding accuracy on WM load was higher by using representational features in the amygdala during encoding and in the hippocampus during maintenance, and by using information flow from the amygdala during encoding and that from the hippocampus during maintenance, respectively. Taken together, our study reveals that WM processing is associated with functional specialization and interaction within the amygdala-hippocampus circuit.
Stony coral tissue loss disease induces transcriptional signatures of in situ degradation of dysfunctional Symbiodiniaceae
Authors: Beavers Kelsey M. , Van Buren Emily W. , Rossin Ashley M. , Emery Madison A. , Veglia Alex J. , Karrick Carly E. , MacKnight Nicholas J. , Dimos Bradford A. , Meiling Sonora S. , Smith Tyler B. , Apprill Amy , Muller Erinn M. , Holstein Daniel M. , Correa Adrienne M. S. , Brandt Marilyn E. , Mydlarz Laura D. 
Published: May 2023

AbstractStony coral tissue loss disease (SCTLD), one of the most pervasive and virulent coral diseases on record, affects over 22 species of reef-building coral and is decimating reefs throughout the Caribbean. To understand how different coral species and their algal symbionts (family Symbiodiniaceae) respond to this disease, we examine the gene expression profiles of colonies of five species of coral from a SCTLD transmission experiment. The included species vary in their purported susceptibilities to SCTLD, and we use this to inform gene expression analyses of both the coral animal and their Symbiodiniaceae. We identify orthologous coral genes exhibiting lineage-specific differences in expression that correlate to disease susceptibility, as well as genes that are differentially expressed in all coral species in response to SCTLD infection. We find that SCTLD infection induces increased expression of rab7, an established marker of in situ degradation of dysfunctional Symbiodiniaceae, in all coral species accompanied by genus-level shifts in Symbiodiniaceae photosystem and metabolism gene expression. Overall, our results indicate that SCTLD infection induces symbiophagy across coral species and that the severity of disease is influenced by Symbiodiniaceae identity.
Driving forces for ultrafast laser-induced sp2 to sp3 structural transformation in graphite
Authors: Song Chenchen , Guan Mengxue , Jia Yunzhe , Chen Daqiang , Xu Jiyu , Zhang Cui , Meng Sheng 
Published: May 2023

AbstractUnderstanding the microscopic mechanism of photoinduced sp2-to-sp3 structural transformation in graphite is a scientific challenge with great importance. Here, the ultrafast dynamics and characteristics of laser-induced structural transformation in graphite are revealed by non-adiabatic quantum dynamic simulations. Under laser irradiation, graphite undergoes an interlayer compression and sliding stage, followed by a key period of intralayer buckling and interlayer bonding to form an intermediate sp2-sp3 hybrid structure, before completing the full transformation to hexagonal diamond. The process is driven by the cooperation of charge carrier multiplication and selective phonon excitations through electron-phonon interactions, in which photoexcited hot electrons scattered into unoccupied high-energy conduction bands play a key role in the introduction of in-plane instability in graphite. This work identifies a photoinduced non-adiabatic transition pathway from graphite to diamond and shows far-reaching implications for designing optically controlled structural phase transition in materials.