bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous spectrophotometric determination of recombined sofosbuvir, ledipasvir and paracetamol together as commonly repurposed drugs for COVID-19 treatment
Authors: Gamal Sherif , Mandour Asmaa A. , Mohamed Gehad G. , Salih Said A. , Ahmed Dina A. 
Published: August 2023

Abstract
Background
COVID-19 has emerged as the most serious outbreak in recent years. Certain medications such as sofosbuvir (SOF), ledipasvir (LDV) and paracetamol (PAR) were proposed as a safer and recommended substance to control symptoms of COVID-19.

Results
Using built-in spectrophotometer software, zero order and derivative spectra of the studied components, two extremely clear, quick, and sensitive spectrophotometric techniques for simultaneous determinations of SOF, LDV, as well as PAR have been developed. LDV was calculated using a zero order absorption spectrum at wavelength maxima of 333 nm. SOF and PAR were evaluated simultaneously using a first derivative spectrophotometer at 247.2 nm and 260.8 nm, respectively. The calibration graphs for SOF, LDV, and PAR are linear over ranges of concentrations of 8–60 µg/mL, 4–22 µg/mL, and 2–14 µg/mL, consequently. The suggested methodologyspecificity was investigated using laboratory manufactured (different ratios) mixtures, which were then effectively used to the analysis of Mpiviropack plus® and Panadol® pills. Valid limitations included accuracy, precision, and specificity. The methodologies were validated in accordance with some ICH standards.

Conclusions
The methods proposed were simple, accurate, precise, and neither require any complex equipment nor specific software.
Curating “Comfort Women”
Authors: Li Lin 
Published: August 2023

AbstractUsing the Liji Alley Museum as a vantage point, this article examines the politics of remembering “comfort women” in contemporary China. I situate the museum within three contexts: Chinese museums on Japanese aggression, the global initiative to create women's museums, and the trans-Asian movement to found museums dealing exclusively with the comfort women issue. On the one hand, I discuss how the Liji Alley Museum has made important interventions by foregrounding the relevance of gender to discussions of civilian wartime experience and by normalizing critical discussion of violence against women. By examining the museum's physical layout, narrative frameworks, and display techniques, I reveal its use of a combination of survivors' testimonies and affective devices to engage visitors. On the other hand, I analyze its limitations vis-à-vis present-day China's gender politics. The museum's reliance on government funding and its incorporation into the state-sponsored system of patriotic education have constricted its potential to offer a more complex critique of the multilayered causes behind comfort women victims' suffering, and to connect the comfort women issue with contemporary discussions of gender-based violence.
Deep Brain Stimulation Lead Localization Variability Comparing Intraoperative MRI Versus Postoperative Computed Tomography
Authors: Yearley Alexander G. , Chua Melissa , Horn Andreas , Cosgrove G. Rees , Rolston John D. 
Published: August 2023

BACKGROUND AND OBJECTIVES:
Commercially available lead localization software for deep brain stimulation (DBS) often relies on postoperative computed tomography (CT) scans to define electrode positions. When cases are performed with intraoperative MRI, another imaging set exists with which to perform these localizations. To compare DBS localization error between postoperative CT scans and intraoperative MRI.

METHODS:
A retrospective cohort of patients who underwent MRI-guided placement of DBS electrodes using the ClearPoint platform was identified. Using Brainlab Elements, postoperative CT scans were coregistered to intraoperative magnetic resonance images visualizing the ClearPoint guidance sheaths and ceramic stylets. DBS electrodes were identified in CT scans using Brainlab's lead localization tool. Trajectory and vector errors were quantified between scans for each lead in each patient.

RESULTS:
Eighty patients with a total of 157 implanted DBS electrodes were included. We observed mean trajectory and vector errors of 0.78 ± 0.44 mm (range 0.1-2.0 mm) and 1.57 ± 0.79 mm (range 0.2-4.2 mm), respectively, between postoperative CT and intraoperative MRI. There were 7 patients with CT scans collected at multiple time points. Trajectory error increased by 0.15 ± 0.42 mm (P = .31), and vector error increased by 0.22 ± 0.53 mm (P = .13) in the later scans. Across all scans, there was no significant association between trajectory (P = .053) or vector (P = .98) error and the date of CT acquisition. DBS electrodes targeting the subthalamic nucleus had significantly greater trajectory errors (P = .02) than those targeting the globus pallidus pars internus nucleus.

CONCLUSION:
Commercially available software produced largely concordant lead localizations when comparing intraoperative MRIs with postoperative CT scans, with trajectory errors on average <1 mm. CT scans tend to be more comparable with intraoperative MRI in the immediate postoperative period, with increased time intervals associated with a greater magnitude of error between modalities.
Metagenomic analysis of coastal Kenya female Aedes aegypti mosquito RNA metaviromes reveal presence of diverse insect specific viruses
Authors: Omuoyo Donwilliams O. , Nyamwaya Doris K. , Kamau Everlyn , Nyagwange James N. , Karanja Henry K. , Gitonga John N. , de Laurent Zaydah , Ngala Jonathan C. , Kinyua Johnson , Rono Martin K. , Mwangangi Joseph M. , Agoti Charles N. , Warimwe George M. 
Published: August 2023

Background: Coastal Kenya has experienced repeated outbreaks of Chikungunya (CHIKV) and Dengue (DENV) viruses mediated by competent Aedes aegypti mosquito populations. These mosquitoes harbor insect specific viruses (ISVs), some of which can prevent arboviral transmission. However, there has been no systematic molecular entomological surveillance in coastal Kenya and the diversity of viruses in local Aedes aegypti populations remains largely unknown. Methods: To obtain a snapshot of the Aedes aegypti viromes from coastal Kenya, we took advantage of a cross-sectional survey of mosquitoes to determine the prevalence of Zika virus. We collected adult mosquitoes using lured Biogent’s sentinel traps at 16 different localities along the Kenyan coast between May to September 2017. Pools of 20 female Aedes aegypti mosquitoes were generated following grouping by morphological characteristics. Presence of arboviruses in the mosquito pools was determined using virus-specific and genera-specific primers with real-time PCR. Metagenomic next generation sequencing (mNGS) on Illumina Miseq and analysis was used to characterize the virome. Results: A total of 16,520 female Aedes aegypti grouped into 826 pools were analysed. Flaviviruses were detected in 69/826 (8.4%) pools by real time PCR. Sequencing generated 8,459/971,754 (0.87%) clean reads that were taxonomically assigned to 16 and 28 viral families and species, respectively. The family Phenuiviridae represented by Phasi Charoen-like phasivirus (PCLV) species was the most abundant, detected in 64/73 (87%) mosquito pools. No pathogenic viruses were identified by mNGS. Phylogenetic analysis revealed local PCLV and Cell fusing agent virus (CFAV) were distinct from global sequences. Conclusions: Our data provides information about virus diversity and composition of the Aedes aegypti mosquitoes from coastal Kenya and contributes to the body of knowledge of the Aedes aegypti virome. To the best of our knowledge, this is the first study to provide this information from this region.
Stochastic Games with General Payoff Functions
Authors: Flesch János , Solan Eilon 
Published: August 2023

We consider multiplayer stochastic games with finitely many players and actions, and countably many states, in which the payoff of each player is a bounded and Borel-measurable function of the infinite play. By using a generalization of the technique of Martin [Martin DA (1998) The determinacy of Blackwell games. J. Symb. Log. 63(4):1565–1581] and Maitra and Sudderth [Maitra A, Sudderth W (1998) Finitely additive stochastic games with Borel measurable payoffs. Internat. J. Game Theory 27:257–267], we show four different existence results. In each stochastic game, it holds for every [Formula: see text] that (i) each player has a strategy that guarantees in each subgame that this player’s payoff is at least his or her maxmin value up to [Formula: see text], (ii) there exists a strategy profile under which in each subgame each player’s payoff is at least his or her minmax value up to [Formula: see text], (iii) the game admits an extensive-form correlated [Formula: see text]-equilibrium, and (iv) there exists a subgame that admits an [Formula: see text]-equilibrium. Funding: This work was supported by the Israel Science Foundation (Nos. 217/17 and 211/22).
Early postnatal care contact within 24 hours by skilled providers and its determinants among home deliveries in Myanmar: Further analysis of the Myanmar Demographic and Health Survey 2015–16
Authors: Show Kyaw Lwin , Aung Pyae Linn , Maung Thae Maung , Myat Su Mon , Tin Khaing Nwe 
Published: August 2023

Background
Access and use of early postnatal care (PNC) by skilled providers are crucial for reducing maternal and newborn deaths. However, use of PNC among the deliveries by skilled providers in some developing countries remains unsatisfactory. Furthermore, literature concerning PNC among home deliveries remains limited, particularly in resource-limited countries such as Myanmar. This study aimed to estimate the prevalence of having early PNC contact by skilled providers and its determinants among home deliveries in Myanmar.

Methods
This cross-sectional study used secondary data from the Myanmar Demographic and Health Survey 2015–16. We included information on all home deliveries in the interviewed mothers aged 15–49 years in the 2 years preceding the survey. Early PNC attendance and its determinants were assessed (using modified Poisson regression with robust variance estimates). All analyses were performed using STATA, Version 15. A p-value <0.05 was considered statistically significant.

Results
Of a total of 2,129 home deliveries, 36.1% (95%CI: 32.4%, 39.9%) did not receive PNC from any providers. Among all home deliveries included in this study, 468 (22.0%, 95%CI: 19.1%, 25.1%) received early postnatal checkup within 24 hours by skilled providers (doctors/nurses/midwives/Lady Health Visitors). Factors associated with early PNC contact among home deliveries by skilled providers included possessing higher education (adjusted Prevalence Ratio (aPR: 1.40, 95%CI: 1.01, 1.94), resident from coastal regions (aPR:1.37, 95%CI: 1.04, 1.80), currently married (aPR: 1.87, 95%CI: 1.01, 3.49), attaining antenatal care (ANC) at least four times (aPR:1.47, 95%CI: 1.22, 1.77), giving birth by a skilled birth attendant (aPR:8.80, 95%CI: 6.67, 11.61), and having access to mass media at least once weekly (aPR:1.23, 95%CI: 1.03, 1.46).

Conclusion
A high percentage of home deliveries (78%) were not receiving early PNC by skilled providers. To facilitate early and safe PNC, expanding the coverage of skilled birth attendants and promoting the utilization of ANC should be strengthened. Targeted health education should be delivered through mass media especially for those with low education levels residing in delta, lowland, hills and plains.
Três braços de rio: formação antirracista em escolas públicas de São Miguel Paulista
Authors: Brasil Figueiredo Erika , Magalhães Perezine Joseli , Alves da Cunha Carvalho Leonardo 
Published: August 2023

Este relato narra o entrelaçamento de iniciativas voltadas parao enfrentamento do racismo em instituições de educaçãobásica e tecnológica na zona leste do município de São Paulo,com foco na formação de professores e estudantes da redepública e na articulação territorial de pedagogias antirracistas.Num contexto de significativa presença da população negravitimizada por múltiplas formas de violência, as açõesdescritas são formas de intervenção envolvendo um projeto de extensão do campus avançado do Instituto Federal de São Paulo, o coletivo Leste Negra e unidades escolares engajadas nesse campo de ação curricular. O artigo se propõe a mostrar como os sujeitos envolvidos desenvolveram atividades específicas que, em determinado momento histórico, acabaram por confluir.
Thin-walled cylindrical shells in engineering designs and critical infrastructures: A systematic review based on the loading response
Authors: Ganendra Ben , Prabowo Aditya Rio , Muttaqie Teguh , Adiputra Ristiyanto , Ridwan Ridwan , Fajri Aprianur , Thang Do Quang , Carvalho Hermes , Baek Seung Jun 
Published: August 2023

Abstract
Cylindrical shell structures are ubiquitous and essential supporting structures in various engineering applications. The aim of this research work is to provide a comprehensive overview of the behavior of cylindrical shell structures under different loading conditions, including external pressure, axial compression, and bending moment. The study found that the behavior of cylindrical shells was affected by their geometry, including diameter, length, thickness, and imperfections. These factors should be carefully considered in the design and analysis of cylindrical shells. Additionally, stiffeners and sandwich structures can be applied to improve the structural performance of cylindrical shells under different loading conditions. The work also highlighted the latest research trends in the field, such as the use of advanced materials, and numerical simulations to improve the understanding and design of cylindrical shell structures. Overall, this study has provided a valuable resource for engineers and researchers working on cylindrical shell structures, helping them to design and analyze the cylindrical shell structures more efficiently and effectively.
Entropy stable non-oscillatory fluxes: An optimized wedding of entropy conservative flux with non-oscillatory flux
Authors: Kumar Dubey Ritesh 
Published: August 2023

AbstractThis work frames the problem of constructing non-oscillatory entropy stable fluxes as a least square optimization problem. A flux sign stability condition is defined for a pair of entropy conservative flux (F∗) and a non-oscillatory flux (Fs). This novel approach paves a way to construct non-oscillatory entropy stable flux (F̂) as a simple combination of (F∗andFs) which inherently optimize the numerical diffusion in the entropy stable flux (F̂) such that it reduces to the underlying non-oscillatory flux (Fs) in the flux sign stable region. This robust approach is (i) agnostic to the choice of flux pair (F∗, Fs), (ii) does not require the computation of costly dissipation operator and high order reconstruction of scaled entropy variable to construct the diffusion term. Various non-oscillatory entropy stable fluxes are constructed and exhaustive computational results for standard test problems are given which show that fully discrete schemes using these entropy stable fluxes do not exhibit nonphysical spurious oscillations in approximating the discontinuities compared to the non-oscillatory schemes using underlying fluxes (Fs) only. Moreover, these entropy stable schemes maintain the formal order of accuracy of the lower order flux in the pair.
The Hierarchy of Coupled Sleep Oscillations Reverses with Aging in Humans
Authors: Züst Marc Alain , Mikutta Christian , Omlin Ximena , DeStefani Tatjana , Wunderlin Marina , Zeller Céline Jacqueline , Fehér Kristoffer Daniel , Hertenstein Elisabeth , Schneider Carlotta L. , Teunissen Charlotte Elisabeth , Tarokh Leila , Klöppel Stefan , Feige Bernd , Riemann Dieter , Nissen Christoph 
Published: August 2023

A well orchestrated coupling hierarchy of slow waves and spindles during slow-wave sleep supports memory consolidation. In old age, the duration of slow-wave sleep and the number of coupling events decrease. The coupling hierarchy deteriorates, predicting memory loss and brain atrophy. Here, we investigate the dynamics of this physiological change in slow wave–spindle coupling in a frontocentral electroencephalography position in a large sample (N= 340; 237 females, 103 males) spanning most of the human life span (age range, 15–83 years). We find that, instead of changing abruptly, spindles gradually shift from being driven by slow waves to driving slow waves with age, reversing the coupling hierarchy typically seen in younger brains. Reversal was stronger the lower the slow-wave frequency, and starts around midlife (age range, ∼40–48 years), with an established reversed hierarchy between 56 and 83 years of age. Notably, coupling strength remains unaffected by age. In older adults, deteriorating slow wave–spindle coupling, measured using the phase slope index (PSI) and the number of coupling events, is associated with blood plasma glial fibrillary acidic protein levels, a marker for astrocyte activation. Data-driven models suggest that decreased sleep time and higher age lead to fewer coupling events, paralleled by increased astrocyte activation. Counterintuitively, astrocyte activation is associated with a backshift of the coupling hierarchy (PSI) toward a “younger” status along with increased coupling occurrence and strength, potentially suggesting compensatory processes. As the changes in coupling hierarchy occur gradually starting at midlife, we suggest there exists a sizable window of opportunity for early interventions to counteract undesirable trajectories associated with neurodegeneration.SIGNIFICANCE STATEMENTEvidence accumulates that sleep disturbances and cognitive decline are bidirectionally and causally linked, forming a vicious cycle. Improving sleep quality could break this cycle. One marker for sleep quality is a clear hierarchical structure of sleep oscillations. Previous studies showed that sleep oscillations decouple in old age. Here, we show that, rather, the hierarchical structure gradually shifts across the human life span and reverses in old age, while coupling strength remains unchanged. This shift is associated with markers for astrocyte activation in old age. The shifting hierarchy resembles brain maturation, plateau, and wear processes. This study furthers our comprehension of this important neurophysiological process and its dynamic evolution across the human life span.
Spontaneous remission of pendulum swinging thyroid disease in Down syndrome
Authors: Fox Katriona , Fitzsimons Aisling , Sharif Farhana , Lee Graham Robert , O’Grady Michael Joseph 
Published: August 2023

Summary
Rare patients who have both thyroid-stimulating hormone (TSH) receptor-stimulating and -blocking antibodies can develop ‘pendulum swinging’ thyroid dysfunction. A 9-year-old girl with Down syndrome was treated with carbimazole for Graves’ disease. After 2 years of treatment, she became profoundly biochemically hypothyroid, and this persisted after carbimazole was discontinued. Low-dose L-thyroxine was commenced. This was subsequently also discontinued as biochemical hyperthyroidism developed. TSH receptor antibody bioassay identified both TSH receptor-stimulating and -blocking antibodies. Mild hyperthyroidism persisted and while consultations regarding definitive treatment were ongoing, medication was not recommenced. Thyroid function normalised spontaneously and she has remained euthyroid for the past 3 years. Previous reports have advised definitive treatment; however, our patient developed spontaneous remission which has been prolonged and definitive therapies have been avoided. It is not yet known how commonly this particular phenomenon occurs.

Learning points

Rare patients who have both TSH receptor-stimulating and -blocking antibodies can switch between hyperthyroidism and hypothyroidism or vice versa during treatment with antithyroid drugs or thyroxine.

Metamorphic thyroid autoimmunity is more common in Down syndrome.

Switching between hyperthyroidism and hypothyroidism and back again is less commonly reported.

Definitive treatment such as radioactive iodine or thyroidectomy are usually recommended.

Prolonged remission was achieved off all medication, without recourse to definitive treatments.
Las habilidades investigativas y su fortalecimiento con la plataforma digital Classroom
Authors: Balanta Rodríguez Oscar Javier , Vivero Ortíz Diana Carolina 
Published: August 2023

La utilización de las nuevas tecnologías en la educación se ha convertido en un reto, las cuales son importantes en la enseñanza cuando se incorporan para mejorar el aprendizaje de las habilidades investigativas de los estudiantes. El siguiente artículo tiene como objetivo principal plantear como se pueden fortalecer las habilidades investigativas través de la observación, indagación, recolección de información y la argumentación. Los estudiantes del colegio Alfredo Bonilla Montaño del municipio de Jamundí del Valle del Cauca, del grado séptimo puedan fortalecer dichas habilidades ya que, se encontraron diferentes falencias en su desempeño académico, donde no muestran interés en las clases de Ciencias Naturales y pocos hábitos de estudio, entre otras.
La falta del desarrollo de habilidades de investigación y el poco uso de tecnologías digitales trae consigo en su mayoría un bajo rendimiento académico, exposiciones, evaluaciones y sustentaciones sin argumentos, trabajos que no dan respuesta a los requerimientos planteados en la clase de Ciencias Naturales, lo cual se ve reflejado en las calificaciones finales de los estudiantes y en algunos casos se presenta la pérdida del año escolar (Albarrán, 2017).
Para el desarrollo de la investigación de este artículo se utilizó un enfoque mixto donde se incluye una orientación cualitativa y cuantitativa recopilando información a través de la implementación de un test de caracterización, un pre test como diagnóstico y un pos test y una rúbrica de satisfacción. Se plantea el desarrollo de una unidad didáctica propuesta en cuatro sesiones con contenidos de aprendizaje referentes a la temática de locomoción en los seres vivos y su importancia en las Ciencias Naturales, las cuales, se planificaron tomando como referencia, competencias, objetivos, contenidos, actividades e instrumentos de evaluación. Estas actividades se desarrollaron con la utilización de la plataforma Classroom, la cual, es una herramienta útil y practica para docentes y estudiantes, con muchas opciones para el trabajo en aula que facilita el desarrollo del proceso educativo que potencia y mejora las habilidades de investigación de los estudiantes, esto enfocado en el modelo pedagógico constructivista que en conjunto con el uso de herramientas tecnológicas apuntan a construir un aprendizaje significativo. La implementación y la evaluación llevaron a la conclusión que las habilidades investigativas tuvieron una mejora y desempeño en un 80% donde al inicio es de un 30%. Lo que muestra que utilizar herramientas tecnológicas y un modelo pedagógico más una serie de actividades bien estructuradas potencian a la mejora de las habilidades para investigar en los estudiantes.