bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneously Blinking Rhodamine Dyes for Single‐Molecule Localization Microscopy
Authors: Chi Weijie , Tan Davin , Qiao Qinglong , Xu Zhaochao , Liu Xiaogang 
Published: May 2023

AbstractSingle‐molecule localization microscopy (SMLM) has found extensive applications in various fields of biology and chemistry. As a vital component of SMLM, fluorophores play an essential role in obtaining super‐resolution fluorescence images. Recent research on spontaneously blinking fluorophores has greatly simplified the experimental setups and extended the imaging duration of SMLM. To support this crucial development, this review provides a comprehensive overview of the development of spontaneously blinking rhodamines from 2014 to 2023, as well as the key mechanistic aspects of intramolecular spirocyclization reactions. We hope that by offering insightful design guidelines, this review will contribute to accelerating the advancement of super‐resolution imaging technologies.
Influence of thickness on impact resistance of glass fiber woven composite laminates
Authors: Deng Yunfei , Wang Yuetong , Cai Xiongfeng , Du Jing , Wei Gang 
Published: May 2023

AbstractTo investigate the influence thickness has on the impact resistance of glass fiber woven composite laminates, a series of impact tests on 1–5 mm‐thick laminates impacted by the hemispherical‐nosed projectile on a one‐stage gas gun are conducted. The influence thickness has on the ballistic limit, energy absorption, failure mode, and damage mechanism of laminates is analyzed. The results show the ballistic limit velocity of 1–5 mm thickness to increase in a linear manner. It is found that the ballistic limit velocity of laminate 5 mm in thickness is 2.8 times greater than that of a laminate that is 1 mm in thickness. As the impact velocity of the projectile increases, the energy absorption of a laminated plate decreases to approximately 10% before becoming stable. Fiber tensile tearing and matrix cracking occurs on the back of the laminate, while the domain failure mode changes from fiber tensile fracture to shear as the velocity of the projectile increases.
Study on the preparation and performance of SiC nanoparticle reinforced polyurethane coatings
Authors: Zhang Jinghua , Chang Yixue , Jin Shaohua , Yang Hongtao , Chen Shusen , Zhang Wei , Chen Yu 
Published: May 2023

AbstractPolyurethane (PU) coatings display several advantages such as easy construction, adjustability, and excellent mechanical properties, and therefore have potential applications in the coating of rocket engines and warheads. However, mechanical strength, high ductility and thermal stability are often difficult properties to combine, which has become a key limitation in efforts toward developing PU coatings for these applications. In this paper, a fast‐curing PU film was developed by reacting between polytetrahydrofuran and diphenylmethane 4,4'‐diisocyanate. The mechanical strengthening effect of SiC nanoparticles on the film was studied and compared with other common fillers, including TiO2, XFM13. The results revealed that SiC nanoparticles substantially increased the mechanical properties in PU coating, increasing the material's tensile strength and elongation at break to 34.14 MPa and 434% respectively. In addition, the inclusion of SiC nanoparticles generally improved the thermal stability and low temperature resistance of PU film. The results generated in this research has established a foundation for the application of PU materials in fields requiring high performance properties, such as rocket engines coatings and warhead manufacture.
Delivery of soluble ethinylestradiol complex by pH‐responsive core‐shell composite hydrogel capsules
Authors: Gong Fengrong , Jiang Lihui , Gao Yanni , Xu Juan , Wang Ting 
Published: May 2023

AbstractEthinylestradiol (EE) is a potent estrogen widely used to treat diseases such as breast cancer, prostate cancer, and menopausal syndrome. The poor aqueous solubility of EE leads to erratic oral absorption, resulting in suboptimal plasma levels. Developing a formulation to enhance the solubility of EE in the gastrointestinal tract would be beneficial to increase the bioavailability of EE. Thereafter, we prepare diethylenetriamine‐β‐cyclodextrin/ethinylestradiol (DETA‐β‐CD/EE) complex, aiming to increase the solubility of EE in water, and design and prepare core‐shell composite hydrogel capsules with aldocellulose and hydroxyethyl cellulose as the core and sodium alginate as the shell. The stability, swelling, drug release behavior and biocompatibility of the core‐shell hydrogel capsules are carefully investigated. And the results show that the prepared hydrogel capsules have the controlled and sustained release ability of soluble DETA‐β‐CD/EE, can achieve pH‐responding to intestinal fluid, and are non‐toxic to normal human cells.
One‐pot preparation of tough, anti‐swelling, antibacterial and conductive multiple‐crosslinked hydrogels assisted by phytic acid and ferric trichloride
Authors: Liu Zhilang , Liu Zhaoqing , Shu Bo , Lian Cuixia , Wu Jialin , Wen Qing , Wu Jiahuan , Yang Zhuohong , Zhou Wuyi , Hu Yang 
Published: May 2023

AbstractThe flexible biodegradable polymer hydrogels have attracted increasing attention in the exploration of multifarious biomedical applications. However, conveniently achieving the synergistic characteristics of favorable mechanical performance, anti‐swelling behavior, antibacterial activity and conductivity into a biodegradable hydrogel remains a significant challenge. In this aspect, we report a facile one‐pot approach to prepare the multiple‐crosslinked PVA (PVA/PA‐Fe) hydrogels assisted by phytic acid (PA) and ferric trichloride. Firstly, PVA polymer chains and PA molecules form hydrogen bonds, meanwhile PA molecules interact with Fe3+ ions by ionic coordinations. Then, PVA polymer chains are crystallized by forming hydrogen bonds after cyclic freeze–thaw process. Based on the synergistic interactions of multiple hydrogen bonds and ionic coordinations in hydrogel system, PVA/PA‐Fe hydrogels possess favorable tensile strength (1222.72 kPa), toughness (1.82 MJ/m3) and anti‐swelling properties. Moreover, the introduction of PA and ferric trichloride successfully endows hydrogel with outstanding antimicrobial activity. Furthermore, the existence of H+ ions ionized by PA, Fe3+ and Cl− ions originating from ferric trichloride provides hydrogel with ionic conductivity (4.91 S/m) and strain responsiveness. Thus, the facile one‐pot preparation approach basing on the multiple‐crosslinked strategy would broaden the path for preparation of multifunctional hydrogels with promising biomedical applications, particularly smart flexible strain sensors.
DprE1 Inhibitors: Enduring Aspirations for Future Antituberculosis Drug Discovery
Authors: Yadav Saloni , Soni Aastha , Tanwar Omprakash , Bhadane Rajendra , Besra Gurdyal S. , Kawathekar Neha 
Published: May 2023

AbstractDprE1 is a crucial enzyme involved in the cell wall synthesis of Mycobacterium tuberculosis and a promising target for antituberculosis drug development. However, its unique structural characteristics for ligand binding and association with DprE2 make developing new clinical compounds challenging. This review provides an in‐depth analysis of the structural requirements for both covalent and non‐covalent inhibitors, their 2D and 3D binding patterns, as well as their biological activity data in vitro and in vivo, including pharmacokinetic information. We also introduce a protein quality score (PQS) and an active‐site map of the DprE1 enzyme to help medicinal chemists better understand DprE1 inhibition and develop new and effective anti‐TB drugs. Furthermore, we examine the resistance mechanisms associated with DprE1 inhibitors to understand future developments due to resistance emergence. This comprehensive review offers insight into the DprE1 active site, including protein‐binding maps, PQS, and graphical representations of known inhibitors, making it a valuable resource for medicinal chemists working on future antitubercular compounds.
A Calcination‐Free Sol‐Gel Method to Prepare TiO2‐Based Hybrid Semiconductors for Enhanced Visible Light‐Driven Hydrogen Production
Authors: Yang Kang , Wei Dan , Jia Chunman , Li Jianwei 
Published: May 2023

AbstractIn recent years, the sol‐gel method has been extensively utilized to develop efficient and stable organic semiconductor composite titanium dioxide (TiO2) photocatalysts. However, the high‐temperature calcination requirements of this method consume energy during preparation and degrade encapsulated organic semiconductor molecules, resulting in decreased photocatalytic hydrogen production efficiency. In this study, we found that by selecting an appropriate organic semiconductor molecule, 1,4‐naphthalene dicarboxylic acid (NA), high‐temperature calcination can be avoided in the sol‐gel process, yielding an organic‐inorganic hybrid material with stable and effective photocatalytic properties. The uncalcined material displayed a hydrogen production rate of 2920±15 μmol g−1 h−1, which was approximately twice the maximum production rate observed in the calcined material. Likewise, the specific surface area of the uncalcined material, at 252.84 m2 g−1, was significantly larger compared to the calcined material. Comprehensive analyses confirmed successful NA and TiO2 doping, while UV‐vis and Mott‐Schottky tests revealed a reduced energy bandgap (2.1 eV) and expanded light absorption range. Furthermore, the material maintained robust photocatalytic activity after a 40‐hour cycle test. Our findings demonstrate that by using NA doping without calcination, excellent hydrogen production performance can be achieved, offering a novel approach for environmentally friendly and energy‐saving production of organic semiconductor composite TiO2 materials.
Sustainable institutional investors and corporate biodiversity disclosure: Does sustainable board governance matter?
Authors: Velte Patrick 
Published: May 2023

AbstractThe purpose of this study is to examine the impact of sustainable institutional investors (SIIs), based on their signatory status to the UN Principles for Responsible Investment (PRI), on corporate biodiversity disclosure (BD). Moreover, the moderating influence of sustainable board governance (critical mass of female directors, sustainability committees, and sustainability‐related executive compensation) as a possible channel of the link between SIIs and BD is analyzed. The study is based on a European sample consisting of 2319 firm‐year observations between 2014 and 2020 (EUROSTOXX 600) and embedded in a stakeholder agency theoretical framework. The results are in line with prior research on sustainable corporate governance and indicate that SIIs have a positive impact on BD and that the included sustainability board governance index strengthens this link. Our results are robust to a battery of sensitivity analyses. This study makes a major contribution to prior analyses, as it appears to be the first study on the link between SIIs and BD and the moderating impact of sustainable board governance. The study has major implications for business practice, regulators and research.
Peak‐to‐average power ratio of selective mapping technology involving a phase generation mechanism based on polar codes for orthogonal frequency division multiplexing with index modulation systems
Authors: Liang Hsin‐Ying 
Published: May 2023

AbstractIn this paper, a novel selective mapping (SLM) method is proposed for reducing the peak‐to‐average power ratio (PAPR) of orthogonal frequency division multiplexing with index modulation (OFDM‐IM) systems. In the proposed method, polar codes are used to construct the SLM phase generation mechanism. This systematic structural design is superior to conventional methods in which phases are randomly generated. Moreover, polar codes and Reed–Muller codes are selected to protect the input data of the OFDM‐IM system. The weight distribution of the Reed–Muller codes is then used to determine the location data of the active subcarriers in the OFDM‐IM system, and these data are used to determine the error correction capacity. Simulation results indicated that the PAPR improvement achieved using the proposed method is similar to that achieved with conventional SLM methods. Moreover, linear block codes are used to construct the active subcarrier selection and SLM phase generation mechanisms to ensure that both mechanisms have systematic structural designs.
Hitchhiking to the abyss
Authors: Fontes Jorge , Castellano‐González Gloria , Macena Bruno C. L. , Afonso Pedro 
Published: May 2023

AbstractWe investigated, for the first time, the hitchhiker‐host fidelity of deep‐diving whale sharks and Chilean devil rays. We found that two of the most ubiquitous oceanic hitchhikers, the common remora and the pilot fish, are able to follow their hosts to bathypelagic depths, where they are exposed to extreme gradients of light, dissolved oxygen, temperature, and pressure. We documented a deep dive of a large whale shark hosting remoras and pilot fish. Common remora was observed at the deepest section of the dive, at 1460 m, where the water temperature was 3.6°C. A pilot fish was recorded at 900 m, during the ascent phase, with the water temperature of 7.5°C. Although the adaptations that allow these hitchhikers to mitigate the impacts of such extreme environmental conditions remain unknown, we discuss these findings in the framework of the ecophysiology of deep diving and the hitchhiker‐host fidelity.
Double deposition/accumulation and double stripping steps system as a new way of decreasing the detection limit and elimination of interferences in stripping voltammetry of inorganic ions: A review
Authors: Gęca Iwona 
Published: May 2023

AbstractThe article reviews an application of double deposition/accumulation and stripping steps as a new and beneficial manner of decreasing a detection limit and/or interferences elimination in stripping voltammetric determination of inorganic ions: Pb(II), Cd(II), Tl(I), U(VI), Au(III), As(III), Se(IV), In(III), Co(II), Cu(II), Bi(III) and Ga(III). A simple design of four‐electrodes system, containing two working electrodes differing in their surface area, allows for conducting two preconcentration and two stripping steps in one measurement cycle and in one voltammetric cell. Considerable analytes preconcentration and, consequently, an increase of sensitivity of determinations was obtained by conducting the first stripping step in a small volume of a solution near the microelectrode surface. An appropriate selection of the conditions of the first deposition/accumulation and the first stripping steps allowed for a minimization/elimination of interference effects. The proposed procedures allows for ultra‐trace levels determinations of mentioned inorganic ions (often impossible to determine by means of traditional three‐electrodes systems) without additional preconcentration outside the electrochemical cell and with the use of mercury‐free electrodes.
Alteration of chromatin high‐order conformation associated with oxaliplatin resistance acquisition in colorectal cancer cells
Authors: Li Peilong , Shang Xueying , Jiao Qinlian , Mi Qi , Zhu Mengqian , Ren Yidan , Li Juan , Li Li , Liu Jin , Wang Chuanxin , Shi Yi , Wang Yunshan , Du Lutao 
Published: May 2023

AbstractOxaliplatin is a first‐line chemotherapy drug widely adopted in colorectal cancer (CRC) treatment. However, a large proportion of patients tend to become resistant to oxaliplatin, causing chemotherapy to fail. At present, researches on oxaliplatin resistance mainly focus on the genetic and epigenetic alterations during cancer evolution, while the characteristics of high‐order three‐dimensional (3D) conformation of genome are yet to be explored. In order to investigate the chromatin conformation alteration during oxaliplatin resistance, we performed multi‐omics study by combining DLO Hi‐C, ChIP‐seq as well as RNA‐seq technologies on the established oxaliplatin‐resistant cell line HCT116‐OxR, as well as the control cell line HCT116. The results indicate that 19.33% of the genome regions have A/B compartments transformation after drug resistance, further analysis of the genes converted by A/B compartments reveals that the acquisition of oxaliplatin resistance in tumor cells is related to the reduction of reactive oxygen species and enhanced metastatic capacity. Our research reveals the spatial chromatin structural difference between CRC cells and oxaliplatin resistant cells based on the DLO Hi‐C and other epigenetic omics experiments. More importantly, we provide potential targets for oxaliplatin‐resistant cancer treatment and a new way to investigate drug resistance behavior under the perspective of 3D genome alteration.
Insertion of the CXXC domain of KMT2A into YAP1: An unusual mechanism behind the formation of a chimeric oncogenic protein
Authors: Teku Gabriel , Nilsson Jenny , Magnusson Linda , Sydow Saskia , Flucke Uta , Puls Florian , Mitra Shamik , Mertens Fredrik 
Published: May 2023

AbstractMost neoplasia‐associated gene fusions are formed through the fusion of the 5′‐part of one gene with the 3′‐part of another. We here describe a unique mechanism, by which a part of the KMT2A gene through an insertion replaces part of the YAP1 gene. The resulting YAP1::KMT2A::YAP1 (YKY) fusion was verified by RT‐PCR in three cases of sarcoma morphologically resembling sclerosing epithelioid fibrosarcoma (SEF‐like sarcoma). In all cases, a portion (exons 4/5–6) encoding the CXXC domain of KMT2A was inserted between exon 4/5 and exon 8/9 of YAP1. The inserted sequence from KMT2A thus replaced exons 5/6–8 of YAP1, which encode an important regulatory sequence of YAP1. To evaluate the cellular impact of the YKY fusion, global gene expression profiles from fresh frozen and formalin‐fixed YKY‐expressing sarcomas were compared with control tumors. The effects of the YKY fusion, as well as YAP1::KMT2A and KMT2A::YAP1 fusion constructs, were further studied in immortalized fibroblasts. Analysis of differentially upregulated genes revealed significant overlap between tumors and cell lines expressing YKY, as well as with previously reported YAP1 fusions. Pathway analysis of upregulated genes in cells and tumors expressing YKY revealed an enrichment of genes included in key oncogenic signaling pathways, such as Wnt and Hedgehog. As these pathways are known to interact with YAP1, it seems likely that the pathogenesis of sarcomas with the YKY fusion is linked to distorted YAP1 signaling.
A database of detrital zircon U–Pb geochronology and Hf isotopes from the Songpan–Ganzi and Western Qinling terranes
Authors: Pan Yingdi , Hu Xiumian 
Published: May 2023

AbstractSince the advent of detrital geochronology, significant progress has been made in the study of sedimentary sources. The detrital zircon U–Pb age spectrum, especially when combined with zircon Hf isotopes, provides a powerful tool for determining the provenance location, nature, and evolutionary history of sediments. The Western Qinling–Songpan tectonic junction, located in central China, is a giant structure on the crustal scale. A total of 20,640 zircon U–Pb ages of 281 sandstone samples from the Songpan–Ganzi and Western Qinling terranes were obtained. Among these, 1,636 zircons from 33 samples contained Hf isotopic data. Moreover, we compiled data on papers, samples, analytical methods, and results and obtained a total of 76 zircon U–Pb and 60 Hf isotope data heads. The obtained dataset has multiple data interfaces, which can be well associated with research or applications in different fields, for provenance analysis, climate change, and paleogeographic reconstruction studies.
Entropy generation analysis on forced and free convection flow in a vertical porous channel with aligned magnetic field and Navier slip
Authors: Balamurugan K. S. , Varma N. UdayaBhaskara , Prasad J. L. Rama 
Published: May 2023

AbstractThe entropy generation rate in a vertical porous channel with injection and suction walls and a uniform magnetic field provided at an angle to the flow direction is studied using an analytical perturbation technique in the presence of Navier slip and buoyancy force. The momentum and energy equations were solved for exemplary values of fluid convection's physical characteristics. Important parameters' impacts on adequate numbers are graphically portrayed and conveyed.
Heat transfer rotating MHD two‐liquid slip flow regime with Hall current
Authors: Raju T. Linga , Satish P. 
Published: May 2023

AbstractIn this paper, we examine the effect of thermal radiation on rotating magnetohydrodynamic two liquid flows of ionized gasses past horizontal channel under slip and Hall conditions. The fluids in the two zones are considered to be immiscible, incompressible, and electrically conducting with various viscosities, thermal and electrical conductivities. We derive the exact solutions for the temperature profiles and coefficients of heat transfer rate at the plates in the two zones by solving governing equations in the presence of slip‐regime analytically. The temperature fields have been figured for various sets of values of the involved governing characteristics to analyze the behavior of heat transport. It has been noted that there is an enhancement in the temperature profile as the slip parameter rises for fixed values of the remaining parameters. Also, stimulations occur in the temperature field, with an increment in Taylor's number. This study may have some significant implementations in biomedical science such as destroying cancer cells during the drug delivery treatment, polishing damaged internal cavities, heart valves, and so forth.
Human rights approaches to reducing infertility
Authors: Shah Payal K. , Gher Jaime M. 
Published: May 2023

AbstractIn April 2023, the World Health Organization (WHO) issued new estimates affirming that one in six individuals experience infertility globally. Yet, many states are unclear on their responsibility to prevent infertility, ensure access to treatment, and to end the harm suffered by individuals who are considered infertile. Responding to this uncertainty, in June 2023, the United Nations Office of the High Commissioner on Human Rights (OHCHR) issued a new research paper explaining states' legal obligations regarding infertility. Importantly, OHCHR underscores that states must take steps to prevent infertility by addressing its root causes and ensure access to treatment. Further, states must address the negative consequences of infertility, including stigma and violence, as well as the discriminatory stereotypes that lead to certain groups facing disproportionate harm from infertility. This article provides an overview of the OHCHR report and explains what this means for healthcare providers, who have a critical role to play in providing care and advocating for legal and policy reform necessary to prevent, diagnose, and treat infertility.
Buying time: The effect of Market Facilitation Program payments on the supply of grain storage
Authors: Janzen Joseph P. , Swearingen Bryn , Yu Jisang 
Published: May 2023

AbstractWe estimate the impact of an unprecedented surge in ad hoc farm payments on grain inventories held by farmers. Payments thought to be decoupled from production may still distort markets if they affect other outcomes such as inventories. Through the Market Facilitation Program, US farmers received approximately 23 billion dollars over two marketing years. The economic theory of commodity storage suggests such a cash injection can increase inventories by lowering the opportunity cost of storage. Using a panel event study framework, we find Market Facilitation Program payments significantly increased grain storage by US farmers without similar impacts on off‐farm inventories.