bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary Diversity and Nutritional Status of Adolescents in Rural Ghana
Authors: Wiafe Michael Akenteng , Apprey Charles , Annan Reginald Adjetey 
Published: March 2023

Background: The rapid biological and physical changes during adolescence require adequate nutrient intake. This study assessed dietary diversity and nutritional status of adolescents living in selected rural areas in Ghana. Method: In this cross-sectional study, 137 young adolescents, aged 10 to 14 years were recruited. Structured questionnaire was used to collect data on sociodemographic, household size and food intake practices. A multiple past 24-hour recall was used to estimate the micronutrients intake. Haemoglobin and anthropometry data were assessed. Dietary diversity score was assessed with 10 food groups described by Food and Agricultural Organization. Descriptive, chi-square, binary regression and partial correlation were used in the data analysis. Results: The prevalence of underweight was 5.5%, overweight 5.8% and anaemia 29.9%. The mean dietary diversity score was 3.8 ± 0.8 and about 84.7% of participants had inadequate dietary diversity. Proportions of adolescents who consumed from the different food groups over a 24-hour period were: grains, white roots and tubers, plantain (100%); pulses (10.2%); nuts and seeds (34.1%); dairy (8%); meat, poultry and fish (86.9%); eggs (7.3%); dark green leafy vegetables (29.9%); other vitamin-A rich fruits and vegetables (2.2%); other vegetables (81%); other fruits (7.3%). Dietary diversity scores were positively and significantly correlated with intake of micronutrient, with correlation coefficients of .169, .186, .191, .173 and .175 for vitamin A, niacin, vitamin B6, iron and zinc, respectively. Meal skipping (AOR = 12.2, P < .001, 95% CI: 3.6-41.7) and snacking (AOR = 5.0, P = .007, 95% CI:1.6-16.7) increased odds of inadequate dietary diversity. Conclusion: The high prevalence of inadequate dietary diversity was positively related to meal skipping and snacking among adolescents. Dietary diversity score was significantly related to the intake of vitamin A, niacin, vitamin B6, iron and zinc. The prevalence of anaemia among our study participants is of public health concern. Adolescents should be encouraged both at home and school to eat from diverse food groups to promote adequate intake of micronutrients.
Emotional dissonance and burnout among child welfare workers: The moderating role of social support from colleagues, supervisors, and organization
Authors: Nielsen Morten Birkeland , Johannessen Håkon A. , Christensen Jan Olav , Finne Live Bakke 
Published: March 2023

Summary Occupational burnout has significant costs for individuals, employers, and the society. Knowledge about risk and protective factors is therefore highly important. This study examined emotional dissonance as a risk factor and colleague, supervisor, and organizational support as protective factors regarding burnout among child welfare workers. It was expected that emotional dissonance would be positively related to burnout, and that social support would attenuate the magnitude of the association. Based on the Psychosocial safety climate model, it was also suggested that organizational support would be negatively associated with levels of emotional dissonance and thereby also burnout. Findings The study was based on a cross-sectional probability sample of employees working in the child welfare service in Oslo municipality, Norway ( N = 678). Emotional dissonance was positively related to burnout. In contrast to expectations, the interaction analyses showed a reverse buffering effect where the examined sources of social support intensified the association between emotional dissonance and burnout. Organizational support had an indirect association with burnout through emotional dissonance. Applications While the cross-sectional nature of the study does not allow for any conclusions about causal effects, the findings indicate that other stress-buffering job resources than social support are more beneficial in efforts focusing on reducing the detrimental impact of emotional demands in child welfare work. However, more knowledge concerning the actual effectiveness of receiving support is necessary to draw more definite conclusions.
Pursuing neutrophils: systematic scoping review on blood-based biomarkers as predictors of treatment outcomes in inflammatory bowel disease
Authors: Magalhaes Diogo , Peyrin-Biroulet Laurent , Estevinho Maria Manuela , Danese Silvio , Magro Fernando 
Published: March 2023

Background: Long-term management of inflammatory bowel diseases (IBD) is challenging and the identification of reliable predictors for treatment outcomes is an unmet need. Neutrophil-related biomarkers have been mainly studied in the feces, but blood analyses have inherent advantages. Objective: To review the recent learnings on the ability of blood-based neutrophil-expressed biomarkers to predict treatment outcomes in IBD. Design: Systematic scoping review. Data sources and methods: We performed a literature search in Pubmed, EMBASE, SCOPUS, Web of Science, ScienceDirect, and Cochrane Central Register of Controlled Trials from inception until May 2022 according to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. All human studies associating blood-based neutrophil-related compounds with the prediction of disease progression, complication onset, or treatment outcomes were included. Results: From 1032 retrieved entries, 34 studies were selected, 32 published in 2013 or later. In all, 17 biomarkers from granules, cytoplasm, plasmatic membrane, and plasma were explored. In total, 1850 Crohn’s disease (CD) and 1122 ulcerative colitis non-duplicated patients were included. The most mentioned biomarkers were nCD64, serum calprotectin (SC), oncostatin M (OSM), neutrophil elastase-generated calprotectin fragment (CPa9-HNE), and triggering receptor expressed on myeloid cells 1 (TREM1). Six biomarkers showed promising results: OSM, SC, eNAMPT, nCD64, TREM1, and CPa9-HNE. Variable positive signals were found for human neutrophil peptide 1-3, LL-37, S100A12, and neutrophil gelatinase–associated lipocalin. No predictive ability was found for the remaining markers. Sharing a neutrophil compartment did not indicate similar behavior. Conclusion: Advances in the last decade began to unveil the untapped potential of the readily accessible blood neutrophil-expressed biomarkers, especially nCD64, TREM1, and CPa9-HNE. Current evidence suggests that future research should focus on well-defined subpopulations instead of a one-size-fits-all biomarker. Registration: https://osf.io/kes9a .
Composition and Bioactivity of a Placental Tissue Particulate (PTP-001) Indicate Greater Potential than Platelet-Rich Plasma for the Treatment of Osteoarthritis
Authors: Flannery Carl R. , Buddin Kelly E. , Begum Laila , Nasert Michael A. , Catalfamo Brooke , Semler Eric J. , Fortier Lisa A. 
Published: March 2023

Objective This study was conducted to compare therapeutically relevant properties of platelet-rich plasma (PRP), a commonly used autologous intra-articular treatment for osteoarthritis (OA), with those of a novel placental tissue particulate, PTP-001, which is in development as a regulated biologic treatment for knee OA. Design Quantitative immunoassays were performed to determine the content of key growth/regulatory biofactors in PTP-001, and in leukocyte-rich (LR)-PRP or leukocyte-poor (LP)-PRP. An anti-inflammatory bioassay was used to evaluate the effects of each treatment on pro-inflammatory cytokine (tumor necrosis factor (TNF)-α) production in a macrophage cell culture system. Gene expression experiments were conducted using a co-culture system of human synoviocytes (pre-stimulated with interleukin (IL)-1β) and articular chondrocytes, with quantitative polymerase chain reaction analyses of the separate cellular compartments. Results The concentrations of several biofactors (e.g., basic fibroblast growth factor, tissue inhibitor of metalloproteases-3, interleukin-1 receptor antagonist) representative of diverse disease-relevant mechanisms of action were significantly higher for PTP-001 relative to LR-PRP or LP-PRP. PTP-001 and PRP preparations were able to reduce TNF-α production in macrophage cell cultures; however, greater variability was observed for PRP in comparison with PTP-001. In the chondrocyte/synoviocyte co-culture experiments, PTP-001 and LR-PRP (but not LP-PRP) significantly reduced chondrocyte MMP13 expression in cultures containing IL-1-pretreated synoviocytes. In addition, ADAMTS5 expression was reduced in the chondrocyte compartment following treatment with PTP-001 relative to PRP. Conclusion These findings support evidence of a potent, multifactorial mechanism of action for a consistently manufactured biologic (PTP-001), which may be of greater therapeutic benefit in comparison with more heterogeneous preparations of PRP which may be generated at the time of treatment.
Usefulness of apparent diffusion coefficient values for distinguishing between squamous cell carcinoma and malignant salivary gland tumor of the head and neck
Authors: Panyaping Theeraphol , Tepkidakarn Nawanwat , Kiatthanabumrung Sivaporn , Wattanatranon Duangkamon , Tritanon Oranan 
Published: March 2023

Purpose The aim of the study was to assess the usefulness of apparent diffusion coefficient (ADC) values for differentiating between SCC and malignant salivary gland tumors of the head and neck. Materials and methods This retrospective cross-sectional study was conducted on 29 patients with SCCs and 10 patients with malignant salivary gland tumors who underwent pretreatment MRI of the head and neck. The minimum and average ADC values of the tumors were measured, with normalized tumor to spinal cord ADC ratios generated. Comparisons of ADC values and normalized ADC ratios between the two tumor types were performed using the unpaired t-test. Results The minimum and average ADC values and normalized average ADC ratios of SCCs (753.17 ± 214.47 × 10−6 mm2/s, 848.79 ± 250.13 × 10−6 mm2/s, and 0.92 ± 0.25, respectively) were significantly lower than those of malignant salivary gland tumors (1084.90 ± 242.60 × 10−6 mm2/s, 1305.90 ± 270.99 × 10−6 mm2/s, and 1.58 ± 0.31, respectively; all p < 0.001). A cutoff value of 1.31 for the normalized average ADC ratio was used to distinguish between SCCs and malignant salivary gland tumors and achieved an area under the curve of 0.93, sensitivity of 96.6%, specificity of 90%, and accuracy of 94.6%. Conclusion ADC value measurement could help differentiate between SCCs and malignant salivary gland tumors.
Reoperation Rate of Internal Fixation for Femoral Neck Fractures in the Elderly – A Retrospective Follow-Up Study in 116 Patients With an Exploration of Risk Factors
Authors: Labmayr Viktor , Borenich Andrea , Pusch Thomas , Reinbacher Patrick , Hauer Georg , Sadoghi Patrick , Leithner Andreas , Berghold Andrea , Puchwein Paul 
Published: March 2023

Aim Internal fixation of femoral neck fractures is a widely used procedure that is comparatively less invasive and faster than hip replacement. While head preserving internal fixation of these fractures are still preferred where feasible, a faster recovery and lower reoperation rates make arthroplasty increasingly more appealing, in spite of being a more invasive option. Our aim was to determine the reoperation rate after internal fixation at our institution and to explore relevant risk factors in a geriatric population. Methods This monocentric follow-up study was conducted analyzing 116 patients aged 65 and older with femoral neck fractures who were surgically treated with either cancellous screws or dynamic hip screws between 2010 and 2017. We retrospectively collected longitudinal data from our patient database, supplemented by a telephone survey, with a follow-up period of at least 18 months. Results Twenty reoperations, due to either a failure of fixation, avascular necrosis, or posttraumatic osteoarthritis, were identified in our cohort, which constituted a reoperation rate of 17.2% (20/116). Fracture displacement was significantly associated with the reoperation risk (HR 8, CI 3-20; P < .001). The reoperation rate was 52.2% in displaced fractures vs 8.9% in undisplaced fractures. No link was found between the reoperation rate and gender, age, BMI, ASA score, type of implant, quality of internal fixation, type of living accommodation, and pre-fracture mobility. Conclusion Internal fixation has been found to be an effective option in elderly patients with undisplaced fractures regardless of their specific age, cognitive ability or physical condition. In displaced fractures the reoperation rate was found to be high, therefore a primary hip replacement should be recommended.
A Systematic Review of Shoulder Arthroplasty in Parkinson's Disease
Authors: Carroll Patrick J , Sheth Ujash , Henry Patrick 
Published: March 2023

Background Parkinson's disease is a degenerative neurological disorder that can cause both motor and nonmotor symptoms. Motor symptoms are associated with increasing the patient's falls risk. Shoulder arthroplasty surgery in this patient cohort is associated with more complications than non-Parkinsonian patients. We sought to identify any increase in complications associated with this patient cohort and any surgical considerations that ought to be taken in light of their disease process. Methods We performed a systematic review of articles using PubMed, MEDLINE, Cochrane Central, and Google Scholar. All studies which included any shoulder arthroplasty surgery for patients with Parkinson's disease were included. Results Complication rates were higher in patients with Parkinson's disease than in the normal arthroplasty cohort in all studies. There was significant heterogeneity between all 8 studies included in the systematic review. Complication rates ranged from 26% to 100%. Complications included subluxation, loosening, malunion, nonunion, scapular notching, stiffness, fracture, baseplate failure, dislocation, and infection. Reoperation rates ranged from 5% to 29%. Conclusion Compared to patients without Parkinson's disease undergoing shoulder arthroplasty, patients with Parkinson's disease achieved similar reductions in pain but inferior clinical function. The range of movement was less predictable, and complication rates were significantly higher in Parkinson's disease patients. This study will aid the surgeon and patient regarding surgical intervention, informed consent, and allow the surgeon to anticipate potential complications of shoulder arthroplasty in this patient cohort.
COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trial
Authors: Sahanic Sabina , Tymoszuk Piotr , Luger Anna K. , Hüfner Katharina , Boehm Anna , Pizzini Alex , Schwabl Christoph , Koppelstätter Sabine , Kurz Katharina , Asshoff Malte , Mosheimer-Feistritzer Birgit , Coen Maximilian , Pfeifer Bernhard , Rass Verena , Egger Alexander , Hörmann Gregor , Sperner-Unterweger Barbara , Helbok Raimund , Wöll Ewald , Weiss Günter , Widmann Gerlig , Tancevski Ivan , Sonnweber Thomas , Löffler-Ragg Judith 
Published: March 2023

BackgroundRecovery trajectories from coronavirus disease 2019 (COVID-19) call for longitudinal investigation. We aimed to characterise the kinetics and status of clinical, cardiopulmonary and mental health recovery up to 1 year following COVID-19.MethodsClinical evaluation, lung function testing (LFT), chest computed tomography (CT) and transthoracic echocardiography were conducted at 2, 3, 6 and 12 months after disease onset. Submaximal exercise capacity, mental health status and quality of life were assessed at 12 months. Recovery kinetics and patterns were investigated by mixed-effect logistic modelling, correlation and clustering analyses. Risk of persistent symptoms and cardiopulmonary abnormalities at the 1-year follow-up were modelled by logistic regression.FindingsOut of 145 CovILD study participants, 108 (74.5%) completed the 1-year follow-up (median age 56.5 years; 59.3% male; 24% intensive care unit patients). Comorbidities were present in 75% (n=81). Key outcome measures plateaued after 180 days. At 12 months, persistent symptoms were found in 65% of participants; 33% suffered from LFT impairment; 51% showed CT abnormalities; and 63% had low-grade diastolic dysfunction. Main risk factors for cardiopulmonary impairment included pro-inflammatory and immunological biomarkers at early visits. In addition, we deciphered three recovery clusters separating almost complete recovery from patients with post-acute inflammatory profile and an enrichment in cardiopulmonary residuals from a female-dominated post-COVID-19 syndrome with reduced mental health status.Conclusion1 year after COVID-19, the burden of persistent symptoms, impaired lung function, radiological abnormalities remains high in our study population. Yet, three recovery trajectories are emerging, ranging from almost complete recovery to post-COVID-19 syndrome with impaired mental health.
Biomimetic nanoparticles in ischemic stroke therapy
Authors: Liu Zihao , Xia Qian , Ma Dengzhen , Wang Zhihai , Li Longji , Han Min , Yin Xianyong , Ji Xiaoshuai , Wang Shan , Xin Tao 
Published: March 2023

AbstractIschemic stroke is one of the most severe neurological disorders with limited therapeutic strategies. The utilization of nanoparticle drug delivery systems is a burgeoning field and has been widely investigated. Among these, biomimetic drug delivery systems composed of biogenic membrane components and synthetic nanoparticles have been extensively highlighted in recent years. Biomimetic membrane camouflage presents an effective strategy to prolong circulation, reduce immunogenicity and enhance targeting. For one thing, biomimetic nanoparticles reserve the physical and chemical properties of intrinsic nanoparticle. For another, the biological functions of original source cells are completely inherited. Compared to conventional surface modification methods, this approach is more convenient and biocompatible. In this review, membrane-based nanoparticles derived from different donor cells were exemplified. The prospect of future biomimetic nanoparticles in ischemic stroke therapy was discussed.Graphic abstract
Berlin Pankow: a 15-min city for everyone? A case study combining accessibility, traffic noise, air pollution, and socio-structural data
Authors: Glock Jan-Peter , Gerlach Julia 
Published: March 2023

AbstractCars are dominating urban traffic in cities around the world, even though daily trips in many cities are often realized with active modes of transportation or public transport. Urban transport planning processes need to adapt to this reality and the necessity of climate change mitigation. Against this background, the research project “Mobility Reporting”, a joint undertaking of the district Pankow in Berlin and researchers from TU Berlin and TU Dresden, established a new, goal-driven, and participative planning process. The process identified local mobility as one of the central planning goals. The 15-min city (FMC) was thus adduced as a benchmark to analyze the district’s current mobility system and development potential. We conducted extensive accessibility analyses to examine the status quo concerning the FMC. We calculated travel times to essential destinations in daily life by foot, public transport, and car. This analysis was accompanied by a mixed online and paper–pencil survey conducted to evaluate the perceived accessibility of people in Pankow. The survey results shed light on the question of which walking time thresholds constitute a “very good” or “good” accessibility. Further analyses included environmental and social variables, allowing us to check whether areas with different accessibility levels also differ regarding the socio-economic characteristics of their inhabitants. For example, do socially advantaged neighborhoods have better local accessibility? Is there a trade-off between exposure to environmental pollution and good accessibility? With this contribution, we shed light on what an FMC is and ought to be. Results from the survey support the normative and political vision of the FMC. Pankow generally offers the merits of a walkable city, showing the expected travel time differences between the dense inner city and the outskirts. Socially disadvantaged neighborhoods are not consistently less accessible. However, there seems to be a trade-off between good accessibility (especially PT accessibility) and correlated externalities of transport, namely air pollution and noise.
Vulnerability and robustness of interdependent transport networks in north-western Italy
Authors: Ferrari Claudio , Santagata Marta 
Published: March 2023

AbstractInfrastructure networks have become increasingly complex, whose progressively higher levels of interdependence make them even more vulnerable. This empirical analysis based on the Morandi bridge collapse examines the robustness and vulnerability of the motorway and railway networks in north-western Italy. By following a network topology-based approach, motorways and railways are studied as one single interconnected multi-layer transport infrastructure. Based on the concepts of geographic and functional interdependence the study provides insight into which nodes (and links) should be restored as quickly as possible when an emergency and destructive event renders them inaccessible. Moreover, it highlights the greater fragility of the intermodal network which opens up the debate on regulation and coordination of restoring measures carried out by the relevant authorities.
Overexpression of the elongation factor MtEF1A1 promotes salt stress tolerance in Arabidopsis thaliana and Medicago truncatula
Authors: Xu Lei , Zhang Lixia , Liu Yajiao , Sod Bilig , Li Mingna , Yang Tianhui , Gao Ting , Yang Qingchuan , Long Ruicai 
Published: March 2023

Abstract
Background
Elongation factor 1 A (EF1A), an essential regulator for protein synthesis, has been reported to participate in abiotic stress responses and environmental adaption in plants. However, the role of EF1A in abiotic stress response was barely studied in Medicago truncatula. Here, we identified elongation factor (EF) genes of M. truncatula and studied the salt stress response function of MtEF1A1 (MTR_6g021805).

Results
A total of 34 EF genes were identified in the M. truncatula genome. Protein domains and motifs of EFs were highly conserved in plants. MtEF1A1 has the highest expression levels in root nodules and roots, followed by the leaves and stems. Transgenic Arabidopsis thaliana overexpressing MtEF1A1 was more resistant to salt stress treatment, with higher germination rate, longer roots, and more lateral roots than wild type plant. In addition, lower levels of H2O2 and malondialdehyde (MDA) were also detected in transgenic Arabidopsis. Similarly, MtEF1A1 overexpressing M. truncatula was more resistant to salt stress and had lower levels of reactive oxygen species (ROS) in leaves. Furthermore, the expression levels of abiotic stress-responsive genes (MtRD22A and MtCOR15A) and calcium-binding genes (MtCaM and MtCBL4) were upregulated in MtEF1A1 overexpressing lines of M. truncatula.

Conclusion
These results suggested that MtEF1A1 play a positive role in salt stress regulation. MtEF1A1 may realize its function by binding to calmodulin (CaM) or by participating in Ca2+-dependent signaling pathway. This study revealed that MtEF1A1 is an important regulator for salt stress response in M. truncatula, and provided potential strategy for salt-tolerant plant breeding.