bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pentraxin-3 as a poor marker of fibrosis in metabolic dysfunction-associated steatotic liver disease among older adults: findings from the PolSenior2 substudy
Authors: Owczarek Aleksander Jerzy , Musialik Joanna , Stefański Adrian , Mossakowska Małgorzata , Zięba Katarzyna , Więcek Andrzej , Chudek Jerzy , Olszanecka-Glinianowicz Magdalena 
Published: February 2025

IntroductionThe study aimed to assess the relationship between plasma pentraxin 3 (PTX-3) levels and the potential diagnosis of fibrosis in metabolic dysfunction-associated steatohepatitis (MASH) in older adults. This was assessed using the Fibrosis-4 index (FIB-4), NAFLD fibrosis score (NFS), and Hepamet fibrosis score (HFS).Materials and methodsThe subanalysis included 2,397 older adults (aged 60 years and older) from the population-based PolSenior2 study, all of whom had risk factors for metabolic dysfunction-associated steatotic liver disease (MASLD) and underwent PTX-3 assessment. The participants were divided into two subgroups according to the FIB-4 values (≤2.67 and &gt; 2.67), three subgroups according to the NFS values (&lt; −1.455, −1.455, and 0.675, and &gt; 0.675), and three subgroups according to the HFS values (&lt; 0.12, 0.12 and 0.47 and &gt; 0.47).ResultsThe empirical cutoff points for PTX-3 levels as a potential marker of liver fibrosis were assessed separately for women and men. In women, the cutoff points for PTX-3 levels based on ROC curve analyses ranged from 1.96 to 2.30 ng/mL (an AUC ranging from 0.596 to 0.643, sensitivity between 39.1 and 61.7%, and specificity between 56.1 and 79.6%). In men, a significant cutoff point was established for FIB-4 (an AUC of 0.549, sensitivity of 39.4%, and specificity of 69.6%). Overall, the accuracy was poor.ConclusionOur study suggests that plasma PTX-3 levels are not sensitive enough to be used as a non-specific marker of liver fibrosis in older adults.
The unmet needs in management, the treatment gap and the burden of migraine in Greece: a Delphi consensus and focus group study from patients’ perspective
Authors: Vikelis Michail , Kourlaba Georgia , Barba Lia , Bilias Konstantinos , Barbalia Elena , Solakidi Argyro , Trafalis Dimitrios , Lioliou Katerina , Zyga Sofia , Karapanayiotides Theodoros , Mitsikostas Dimos-Dimitrios 
Published: February 2025

IntroductionMigraine is a chronic, debilitating neurological disease affecting more than 1 billion patients, worldwide. Even though migraines are not life-threatening, they have profound effects on individuals, families, and society.ObjectiveThe aim of this study was to describe patients’ perspectives on socioeconomic and humanistic burden of migraine, as well as the unmet medical needs in the clinical management of migraine, in Greece.MethodsA mixed study design of a Delphi panel and a focus group was conducted, in which 16 and 9 episodic migraine patients from the two Greek migraine patient associations participated, respectively. A structured questionnaire of 45 statements regarding burden of disease diagnosis, treatment and unmet needs was used to collect data at Delphi consensus panel. An open and balanced discussion with all participants took place, under the co-ordination of one moderator during the focus group. At each round of the Delphi panel, the percentage of participants who responded “Agree/Strongly Agree,” “Disagree/Strongly disagree” and “Neither Agree nor Disagree” was calculated. The consensus threshold was set at 70% of responses. A thematic analysis was performed for the focus group.ResultsConsensus was achieved on 34 out of 45 statements. Thematic analysis revealed that patients face severe problems at work due to a lack of understanding and awareness of migraine burden from colleagues and employees, they are forced to modify their daily activities to avoid migraine attacks, and they experience prolonged diagnostic and treatment journey since they visit different medical specialties until they find the one who will be able to effectively help them manage their migraine. Additionally, they expressed concerns regarding the management of their disease due to patient-physician communication gap, dissatisfaction with traditional oral preventive therapies and lack of therapeutic options for older ages and in case of existence of specific comorbidities.ConclusionParticipants agreed that Migraine has a multifaceted impact on several aspects of patients’ lives. Patient-centered care, better training for healthcare providers, targeted therapies, and improved communication tools emerged as key factors in addressing the unmet medical needs of migraine sufferers.
Structural analysis and treatment of acute liver injury of polysaccharides from the Radix Actinidiae Chinensis
Authors: Ding Zhongpeng , Ying Qianyi , Lei Jing , Zhang Ningchen , Xia Yu , Du Yilin , Xu Beihua , Shi Senlin 
Published: February 2025

ObjectiveTo investigate the therapeutic effects of the PRAC on acute liver injury and its potential as an ingredient in drugs and nutraceuticals.MethodsMicrowave-assisted extraction technology combined with Box-Behnken model combined with the three kinds of artificial neural networks was used to optimize PRAC extraction process. Characterize the structure and composition of PRAC. In order to prevent PRAC from being degraded by the gastrointestinal environment, PRAC-loaded liposomes were fabricated. The efficacy of PRAC-loaded liposomes was evaluated by three acute liver injury animal models prepared according to different mechanisms.ResultsThe best yield of PRAC was 4.49%, and the purity reached up to 86.53% by optimizing the microwave parameters using Box-Behnken model combined with the three kinds of artificial neural networks. PRAC was characterized as a galactan having a backbone consisting predominately of →4)-D-Galp-(1→ and →4)-D-Glcp-(1→ with a molecular weight of 12.713 kDa. The PRAC-loaded liposome obtained had a size about 340 nm with a polydispersity index 0.234. The entrapment efficiency was 70.12% and the drug loading was 1.24%. Liposomes can be fully released in the gastrointestinal environment within 12 h and have long-term stability at 4°C. The therapeutic effect of PRAC liposomes on acute liver injury was confirmed by three animal models of acute liver injury.ConclusionPRAC is a potential drug for the treatment of acute liver injury.
In silico oncology: a mechanistic multiscale model of clinical prostate cancer response to external radiation therapy as the core of a digital (virtual) twin. Sensitivity analysis and a clinical adaptation approach
Authors: Stamatakos Georgios , Kolokotroni Eleni , Panagiotidou Foteini , Tsampa Stamatia , Kyroudis Christos , Spohn Simon , Grosu Anca-Ligia , Baltas Dimos , Zamboglou Constantinos , Sachpazidis Ilias 
Published: February 2025

IntroductionProstate cancer (PCa) is the most frequent diagnosed malignancy in male patients in Europe and radiation therapy (RT) is a main treatment option. However, current RT concepts for PCa have an imminent need to be rectified in order to modify the radiotherapeutic strategy by considering (i) the personal PCa biology in terms of radio resistance and (ii) the individual preferences of each patient.MethodsTo this end, a mechanistic multiscale model of prostate tumor response to external radiotherapeutic schemes, based on a discrete entity and discrete event simulation approach has been developed. Following technical verification, an adaptation to clinical data approach is delineated. Multiscale data has been provided by the University of Freiburg. Additionally, a sensitivity analysis has been performed.ResultsThe impact of model parameters such as cell cycle duration, dormant phase duration, apoptosis rate of living and progenitor cells, fraction of dormant stem and progenitor cells that reenter cell cycle, number of mitoses performed by progenitor cells before becoming differentiated, fraction of stem cells that perform symmetric division, fraction of cells entering the dormant phase following mitosis, alpha and beta parameters of the linear-quadratic model and oxygen enhancement ratio has been studied. The model has been shown to be particularly sensitive to the apoptosis rate of living stem and progenitor cells, the fraction of dormant stem and progenitor cells that reenter cell cycle, the fraction of stem cells that perform symmetric division and the fraction of cells entering the dormant phase following mitosis. A qualitative agreement of the model behavior with experimental and clinical knowledge has set the basis for the next steps towards its thorough clinical validation and its eventual certification and clinical translation. The paper showcases the feasibility, the fundamental design and the qualitative behavior of the model in the context of in silico experimentation.DiscussionFurther data is being collected in order to enhance the model parametrization and conduct extensive clinical validation. The envisaged digital twin or OncoSimulator, a concept and technologically integrated system that our team has previously developed for other cancer types, is expected to support both patient personalized treatment and in silico clinical trials.
Size and site matter: the influence of corpus callosum subregional lesions on the magnitude of cross-education of strength
Authors: Morrone Marco , Martinez Gianluca , Achene Antonio , Scaglione Mariano , Masala Salvatore , Manca Andrea , Deriu Franca 
Published: February 2025

IntroductionCross-education is an established yet not fully understood phenomenon involving interhemispheric processes within the corpus callosum (CC) that result in strength gains in the untraining limb following training of the contralateral homologous muscles. There is a substantial lack of cross-education studies employing lesional models. This study employed the model of multiple sclerosis, a condition typically featuring demyelinating callosal lesions, to pinpoint CC subregions that mediate cross-education, potentially fostering the mechanistic understanding of the interlimb transfer.MethodsNine individuals with relapsing-remitting multiple sclerosis (median Expanded Disability Status Scale: 3.5) and focal CC lesions underwent a 6-week, high-intensity isokinetic training program (≥80% maximal effort at 10°/s) targeting their stronger ankle dorsiflexors. Sagittal FLAIR MRI scans were segmented into five CC subregions (CC1–CC5), with lesion volumes quantified for each subregion. Strength (peak concentric torque at 10°/s) was measured bilaterally before (PRE) and after (POST) training to determine cross-education, defined as the percentage increase in torque of the untrained, weaker limb. Correlations between lesion volumes in CC subregions and cross-education were analyzed.ResultsBoth the trained (+21.5 ± 15.8%, p = 0.002) and untrained (+35.2 ± 24.9%, p = 0.003) limbs demonstrated post-training strength gains, reducing but not eliminating inter-limb asymmetry. Lesions specifically in the rostral body (CC2) correlated with reduced cross-education magnitude (rs = −0.670, p = 0.048) and smaller improvements in strength asymmetry (rs = 0.809, p = 0.008). No associations were detected in other CC subregions.ConclusionThese findings highlight the pivotal role of specific CC subregions, particularly the rostral body, in mediating cross-education of strength. These findings advance our understanding of CC role in the interhemispheric dynamics underpinning cross-education. Routine MRI can identify patients without CC2 lesions who may benefit from cross-education, providing a practical approach to improving muscle strength when weaker muscles cannot be directly trained.Clinical Trial RegistrationClinicaTrials.Gov, identifier NCT02010398
Analysis of fruit thinning effect and underlying mechanism using metamitron on ‘Gala’ apples
Authors: Chen Ru , Nie Peixian , Wang Laiping , Wang Guiping , Zhang Chunxiang , Zhao Xianyan , Xue Xiaomin 
Published: February 2025

To address the problems of artificial apple thinning, which are time-consuming, labor-intensive, and inefficient, this study examined the fruit thinning effect and mechanism of spraying metamitron at the young fruit stage on Gala apples grown on dwarfing inter-stocks. The results showed that spraying 500mg·L-1metamitron twice, at 3 mm and 9 mm fruit diameters, significantly reduced the fruit setting rate of inflorescences and flowers, thereby increasing the single fruit ratio. The photosynthetic parameter (Pn) and chlorophyll fluorescence parameters (Fv/Fm, ΦPSII, qP, and NPQ) were significantly inhibited by the treatment, resulting in a noticeable decrease in soluble sugar content. The treatment significantly increased abscisic acid (ABA) content and decreased the (Z+GA3+IAA)/ABA ratio. These results suggest that metamitron effectively thins apple fruit, with its mechanism likely related to damage to the leaf PSII reaction center structure, obstruction of photosynthetic electron transfer, insufficient soluble carbohydrate supply due to reduced photosynthetic rate, increased ABA content, and decreased auxin hormone/ABA ratio.
Pulley ring suture increases shoulder stability after biceps tendon transposition
Authors: Zhang Duzheng , Wu Jiezhou , Zhang Liyun , Chen Qiyun , Wang Chao , Cai Ming , Cong Ruijun 
Published: February 2025

ObjectiveModified double-row biceps tenodesis (MDBT) has been proved to be effective in treating slap injuries, but the impact of closing the rotator cuff gap remained postoperatively (the Pulley ring repair) on the long-term shoulder function and stability has not been conclusively investigated.MethodsA retrospective study was conducted on 157 patients with isolated unilateral type II SLAP lesions treated with MDBT from January 2019 to January 2023. 77 patients were without the Pulley ring repair (group A) and the remaining 80 patients were with the Pulley ring repair (group B). T-test, Anova, and chi-square analyses were used to compare the two groups for any statistical differences in the 37 variables. Lasso regression was used to screen and analyze the variables, assess risk, and construct a predictive assessment model.ResultsThere were significant differences between the two groups at 1 year in ASES and UCLA score (p &lt; 0.01). Risk factors screened by LASSO regression were five including Grouping information, Mean T value of bone mineral density, and 3 Months post operation's UCLA score. These statistically significant variables and their coefficients were used to build a generalized linear equation and selected to build the final model including Grouping information (OR:1.61E + 01;95% CI:5.8854–52.5200), Mean T value of bone mineral density (OR:6.95E + 00;95% CI:2.4695–25.6797) and 3 Months post operation UCLA score (OR:1.77E + 00;95% CI:1.4810–2.2539).ConclusionsCompared with the traditional MDBT, the modified MDBT is more effective in improving the long-term function of the glenohumeral joint and better restoring the biological state of the glenohumeral joint.
How to choose rib resection in minimally invasive lateral approach thoracolumbar junction corpectomy: radiographic analysis and case illustrations
Authors: Liu Fengyu , Gu Zhenfang , Sun Xianze , Meng Xianzhong 
Published: February 2025

PurposeThe thoracolumbar junction (T10-L2) is a common site for spinal disorders such as fractures, tumors, and infections. Thoracolumbar vertebral corpectomy can be performed through the extracoelomic spaces approach (retropleural, retroperitoneal, and retrodiaphragmatic). The standard for selecting rib resection has not been described. We explored the criteria for rib resection in minimally invasive lateral approach thoracolumbar corpectomy through radiographic analysis and case illustrations.MethodsWe proposed the criteria for rib excision after reviewing the three-dimensional CT imaging of 300 patients' ribs. The vertebral body is divided obliquely into four zones. Ribs need to be removed when they overlap zones II and III, but not when they overlap zones I and IV. Surgery was performed according to this criteria to verify the feasibility of this criteria.ResultsFrom January 2024 to October 2024, 19 patients experienced minimally invasive lateral approach thoracolumbar corpectomy. Sixteen patients needed rib resection (the ninth rib resection: 4, the 10th rib resection: 12). Three patients did not require rib resection but underwent vertebra corpectomy through the intercostal. Two patients had pleural tear and were repaired during surgery. The VAS reduced from 8.9 ± 1.1 preoperatively to 1.2 ± 0.9 at final follow-up (P &lt; 0.001).ConclusionsThis may be an appropriate criterion for determining rib resection in minimally invasive lateral approach thoracolumbar corpectomy. The vertebral body is divided obliquely into four zones. Ribs need to be removed when they overlap zones II and III, but not when they overlap zones I and IV.
Dog agility tunnel risks for incidents
Authors: Ford Dianne P. , Cullen Kimberley L. , Stickney Kathryn , Sharman Murray , Cullen John D. 
Published: February 2025

BackgroundFlexible tunnels are the second most common obstacle on all dog agility courses, surpassed only by jumps. There has been a lot of debate and concern regarding risk factors associated with slips, falls and delayed exits (unseen slips, missteps, trips, falls). However, only one study was found which focused on the tunnel-related injuries, and it relied on handler reporting and did not consider base rates of the risk factors. As such, it is currently unknown which risk factors are statistically predictive of incidents. This study addresses this gap.MethodsObservational data from local, regional, national and international agility competitions (between June 30, 2023, to September 22, 2024) were collected from various agility organizations and countries by a team of researchers who are also judges and/or coaches within the sport. Tunnel, equipment, competition and course attributes, ground type and conditions along with tunnel incidents (slips, falls, and delayed exits) were recorded. Correlation, regression analyses, and chi-squared tests of independence were conducted to identify the relevant factors associated with incident rates.ResultsThe data included 563 tunnels (75.0% were incident free), with 30,418 tunnel performance observations (1.552% were incidents). The identified factors associated with incidents include tunnel characteristics (equipment specifications, shape on course), type and density of fixtures, course design (shape in design, angle of approach), ground and conditions. Their association with incident occurrence will be further detailed below.DiscussionSeveral previously assumed risk factors were relevant; however, some were not supported, and additional new factors were identified. Implications for future research and for organizations, judges, trial hosts, and competitors are discussed.
Em torno da Natureza das coisas e das imagens
Authors: Vieira Elisa Amorim 
Published: February 2025

Abstract:This article seeks to analyze representations of nature present in the photobook Nature of Things, by Pedro Motta, based on the reading of the poem On the Nature of Things - De rerum natura, by Tito Lucrécio. This examination argues that, when constructing his description of the nature of things through an Epicurian-based philosophical-scientific treatise, the Roman poet explores both the ways in which truth should be expressed, and truth as a theme in itself. In turn, the six photographic series analyzed from Motta's photobook, reveal an ambiguous game between reality and fiction, which is fundamental to insert these pieces in the field of contemporary aesthetics, at the same time as they demonstrate the ethical concern that permeates the artist's work. Through a careful analysis of these two homonymous pieces, this article reflects upon today's devastating process of exploitation, commodification, and deterioration of nature.
PENDAMPINGAN PENGOLAHAN KARBOHIDRAT ALTERNATIF UNTUK ANAK DI DESA GAUM KARANGANYAR
Authors: Danang Adhi Kusuma  , Usmani Haryanti  , Pipit Fitria Yulianto  , Eriek Satya Haprabu  , Fatkhul Imron  , Taufik Hidayat  
Published: February 2025

Pengabdian ini bertujuan untuk memberikan ide baru pada para orangtua untuk mencari alternative karbohidrat lain. Tampilan karbohidrat dasar menjadikan anak bosan makan dengan menu yang itu-itu sja. Makanan bergam bentuk sangat di perlukan untuk menambah minat makan pada anak. Selera makan anak akan naik apabila melihat dan mencium aroma dari makanan tertentu. Pengolahan makanan menjadi kunci dari suksesnya anak lahap dalam makan. Masalah makan pada anak sudah menjadi hal wajar dalam keseharian orangtua, terutama para ibu. Tapi memaksakan anak untuk makan itu juga bisa menimbulkan trauma tesendiri pada anak. Sehingga perlu ada nya terobosan baru yakni mencari dan membuat karbohidrat alternative untuk makan anak. Bahwasanya karbohidart sangat di perlukan karena karbohidrat menjadi sumber energy bai bagi tumbuh kembang anak dalam kesehariannya.
PENINGKATAN PEMBINAAN PRESTASI SKILL PADA CABANG OLAHRAGA HOCKEY DI KABUPATEN DEMAK
Authors: Darmanto Fery , Moch. Fahmi Abdul Azis  , Harry Pramono  , Adi Sasmito Utomo  , Siti Kholifah  , Reza Rifqi Kamal  
Published: February 2025

Kegiatan pengabdian ini berkontribusi pada pengembangan skill atlet usia muda khususnya yang berusia 15-21 tahun yang bertujuan untuk meningkatkan prestasi olahraga hockey ruangan. Jumlah atlet remaja yang dmiliki oleh Kabupaten Demak kurang lebih 65 atlet usia muda yang terdiri dari usia SD-SMP-SMA. Hasil analisa awal program latihan secara kontinyu dan model latihan dalam peningkatan prestasi olahraga hockey di Kabupatan Demak berpotensi dan menyumbangkan atlet yang mumpuni bisa bersaing dengan Kota/Kabupaten di Jawa Tengah. Permasalahan FHI Kabupaten Demak adalah SDM Pelatih yang kurang memadai, Potensi yang dimiliki adalah minat yang sangat tinggi dari para atlet yang berasal dari siswa untuk mau menekuni olahraga hockey ruangan. Sehingga dengan pengabdian ini merupakah salah satu solusi agar skill yang dimiliki atlet FHI Kabupaten Demak semakin meningkat. Metode yang digunakan adalah 1). Pembekalan teori teknik dan taktik, 2). Praktek di lapangan, 3). Mini game, 4). Analisis kesalahan 5). Analisis video pertandingan hockey internasional, 6). Pendampingan selama 2 bulan. Hasil dari pengabdian ini adalah rencana tindak lanjutan, yaitu, 1). Kerjasama keberlanjutan khususnya dalam pembinaan atlet usia muda, 2). Sasaran berikutnya prestasi FHI Kabupaten Demak mengikuti Pra-PORPROV Provinsi Jawa Tengah Tahun 2025, 3). Pendampingan lain adalah, diskusi dan pemberian pengetahuan baru terhadap pelatih dalam mentargetkan agar lolos dalam Pra-PORPROV Tahun 2025, 4). Dalam perkembangannya pendampingan berlanjut. Sehingga diharapkan dari kegiatan ini memberikan wawasan dan motivasi kepada atlet remaja FHI Kabupaten Demak.