bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coping with audit society pressures: a review of NGO responses to funder accountability demands
Authors: Boomsma Roel 
Published: September 2023

Purpose
This paper aims to extend some of the theoretical propositions of Michael Power’s (1997) audit society thesis by exploring the capacity of organisations to push back against external accountability pressures. The paper positions the literature on non-governmental organisation (NGO) accounting and accountability as a “case study” against which the notion of the audit society is put to the test.

Design/methodology/approach
A qualitative meta-synthesis of the accounting literature is used to analyse how NGOs have responded to audit society pressures – most notably funder pressures to adopt formalised accountability mechanisms. The different responses of NGOs to funder accountability demands are analysed using Christine Oliver’s (1991) typology of strategic responses to institutional processes.

Findings
This review of the accounting literature unveils that NGOs can adopt a range of strategic responses to funder accountability pressures that vary from passive conformity to proactive manipulation. The findings confirm that NGOs often perceive acquiescence to funder accountability demands as necessary to ensure organisational survival. Yet, the author also found that NGO resistance to funder accountability pressures is more common than previously assumed. Five dominant forms of “accountability resistances” emerged from the analysis: evading accountability, disguising accountability, shielding accountability, negotiating accountability and shaping accountability.

Originality/value
By conducting a qualitative meta-synthesis of the accounting literature, the author was able to integrate the findings of prior research on NGO resistance to funder accountability demands, guide future research and extend Michael Power’s (1997) work by developing a more nuanced understanding of how organisations respond to external accountability pressures.
The Scylla State. A gendered understanding of the experiences of marginalised women in the United Kingdom
Authors: Hamer Rebecca 
Published: September 2023

AbstractSince the formation of the 2012 Coalition government, the UK has been subject to 12 years of neoliberal policy enacted with ferocity and vigour. This has comprised austerity measures including the retrenchment of welfare via the reshaping of the welfare state and public services according to business practices, ideals of individual responsibilisation and overwhelmingly, the notion of reducing the state's ideological and fiscal responsibility for equity and social welfare. The neoliberal state has been conceptualised by Loic Wacquant as a Centaur, boasting a liberal head, yet one atop an authoritarian body whose focus is the designated ‘underclasses’, the socially and economically non‐compliant. The Centaur takes away with one hand while ruling punitively with the other, specifically via ‘prisonfare’ and ‘workfare’ to compel submission to precarious and sub‐par employment. Although compelling, the Centaur State is justifiably critiqued for its blindness to gender and focus upon the manifestation of neoliberalism in the States. By exploring the stories of 23 women in the UK with histories of survival sex working and problematic drug use, a distinct gendered alternative reality emerges of the operation and machinations of the neoliberal state. Rather than a Centaur, marginalised women experience the Scylla State, a covert, hydra‐headed beast motivated by neo‐Victorian ideals of ‘womanfare’. The operations of the Scylla State are unpredictable, replicate traumatising interpersonal experiences and variously involve surveillance, coercion, conditionality and the responsibilisation of victimhood to justify increasingly punitive responses to women's survival strategies in the face of increasing trauma and deprivation.
Chimeric antigen receptor T‐cell therapy: Prospective observational study of unplanned emergency department presentations
Authors: Bak Grace G , Micklethwaite Kenneth , Maddock Karen , Coggins Andrew 
Published: September 2023

AbstractObjectiveChimeric antigen receptor T‐cell (CAR‐T) therapy is an emerging treatment for refractory hematologic malignancy. Unplanned ED presentations following CAR‐T present the increasing need for an integrated model of care that allows for the early recognition of its specific complications.MethodsThis is a prospective observational study at a tertiary centre. CAR‐T patients (n = 17) were universally enrolled into a study registry by treating providers. These patients were flagged by investigators to trigger a pop‐up notification CAR‐T information warning at ED triage. Medical records were reviewed 90 days for unplanned presentations, complications and patient‐oriented outcomes.ResultsPatients receiving CAR‐T frequently encountered toxicity within 7 days of therapy. This was typically mild and occurred in an inpatient setting. Medical record review revealed five unplanned ED presentations (that were recognised as post CAR‐T) and not directly attributable to specific toxicities.ConclusionIf CAR‐T therapy is to be used more widely especially in an outpatient model of care, a standardised ED model of care for recognition of specific complications is needed.
Firearm restrictions in domestic violence protection orders: Implementation, vetting, compliance, and enforcement
Authors: Ellyson Alice M. , Adhia Avanti , Shanahan Sandra , Alsinai Aisha , DiMascolo Lisa , Reygers Maxmilliaan , Bowen Deirdre , Rowhani‐Rahbar Ali 
Published: September 2023

AbstractResearch SummaryWe quantified the implementation of WA state's domestic violence (DV)‐related firearm prohibitions (RCW9.41.800) by the courts and the Regional Domestic Violence Firearms Enforcement Unit (RDVFEU), a regional approach to compliance promotion. We measured implementation, vetting, compliance, and enforcement of firearm prohibitions before (2014–2016) and after (2018–2020) the RDVFEU was implemented using a 55% random sample of granted domestic violence protection orders (DVPOs) in King County, WA (n = 3543). We evaluated differences in judicial orders to surrender firearms and other dangerous weapons (OTSWs), respondent documented compliance, and respondent weapon and/or firearm relinquishment before and after implementation. Compared to DVPOs granted prior to RDVFEU implementation, granted DVPOs after RDVFEU implementation were at least 4.5 times more likely to include an OTSW. RDVFEU implementation was also associated with at least 3.4 times the odds of respondent documented compliance and at least 3.3 times the odds of respondent relinquishment of at least one firearm and/or other dangerous weapon. These findings demonstrate RDVFEU implementation was associated with benefits at each stage of the protection order process with improvements in both judicial enforcement and respondent compliance. Overall, RDVFEU implementation was associated with improvements in granted orders to surrender weapons, respondent compliance, and relinquishment.Policy ImplicationsDV‐related firearm prohibitions can be supported by interdisciplinary teams within the legal system to promote respondent compliance and enhance safety planning for DV victim–survivors.
Delineating the phenotype of PNPLA8‐related mitochondriopathies
Authors: Abdel‐Hamid Mohamed S. , Abdel‐Salam Ghada M. H. , Abdel‐Ghafar Sherif F. , Zaki Maha S. 
Published: September 2023

AbstractPathogenic variants in PNPLA8 have been described either with congenital onset displaying congenital microcephaly, early onset epileptic encephalopathy and early lethality or childhood neurodegeneration with progressive microcephaly. Moreover, a phenotype comprising adulthood onset cerebellar ataxia and peripheral neuropathy was also reported. To our knowledge, only six patients with biallelic variants in PNPLA8 have been reported so far. Here, we report the clinical and molecular characterizations of three additional patients in whom exome sequencing identified a loss of function variant (c.1231C>T, p.Arg411Ter) in Family I and a missense variant (c.1559T>A, p.Val520Asp) in Family II in PNPLA8. Patient 1 presented with the congenital form of the disease while Patients 2 and 3 showed progressive microcephaly, infantile onset seizures, progressive cortical atrophy, white matter loss, bilateral degeneration of basal ganglia, and cystic encephalomalacia. Therefore, our results add the infantile onset as a new distinct phenotype of the disease and suggest that the site of the variant rather than its type is strongly correlated with the disease onset. In addition, these conditions demonstrate some overlapping features representing a spectrum with clinical features always aligning with different age of onset.
Genomics and transcriptomic alterations of the glutamate receptors in acute myeloid leukemia
Authors: Alqahtani Amani , Wang Mengxi , Lou Mimi , Alachkar Houda 
Published: September 2023

AbstractGlutamine and glutamate have been widely explored as potential therapeutic targets in acute myeloid leukemia (AML). In addition to its bioenergetic role in leukemia cell proliferation, L‐glutamate is a neurotransmitter that acts on glutamate receptors. However, the role of glutamate receptors in AML is largely understudied. Here, we comprehensively analyze the genomic and transcriptomic alterations of glutamate receptor genes in AML using publicly available data. We investigated the frequency of mutations in the glutamate receptor genes and whether an association exist between the presence of these mutations and clinical and molecular characteristics or patient's clinical outcome. We also assessed the dysregulation of glutamate receptor gene expression in AML with and without mutations and whether gene dysregulation is associated with clinical outcomes. We found that 29 (14.5%) of 200 patients with AML had a mutation in at least one glutamate receptor gene. The DNMT3A mutations were significantly more frequent in patients with mutations in at least one glutamate receptor gene compared with patients without mutations (13 of 29 [44.8%] vs. 41 of 171 [23.9%], p value: 0.02). Notably, patients with mutations in at least one glutamate receptor gene survived shorter than patients without mutations; however, the results did not reach statistical significance (overall survival: 15.5 vs. 19.0 months; p value: 0.10). Mutations in the glutamate receptor genes were not associated with changes in gene expression and the transcriptomic levels of glutamate receptor genes were not associated with clinical outcome.
Searching for meaning during the pandemic: Delivery riders’ motivations in keeping the city of Wuhan running
Authors: Ji Guangxu , Zhai Huiwen , Zhou Daming , Lavender Christopher 
Published: September 2023

AbstractThis article explores the motivations behind the moral code of delivery rider migrant workers who served in Wuhan, China, during the pandemic. Based on ethnographic research, we analyze how riders experienced the challenging situation of everyday work. Influenced by socialist and neoliberal contexts, the riders’ actions reflect diversified moral values combining individualistic and collectivist ethics. The precarious conditions gave rise to alternative visions and opportunities for the migrant laborers. They created a new mode of autonomy with economic rationality and emotional bonds to a geographical locality. Simultaneously, the riders’ identity was temporarily reshaped by both the public and themselves, creating responsibility and meaning. This act of strong “social responsibility” reconnected individuals trapped in the plight of the pandemic. This kind of altruistic behavior exemplified the process of people seeking meaning through their work.
Agglomeration factors and the geography of growing early‐stage businesses in Chile
Authors: Modrego Félix , Atienza Miguel , Hernández Leónidas 
Published: September 2023

AbstractNew models of agglomeration cast the urban productivity premium as the outcome of agglomeration economies, a spatial sorting of skilled entrepreneurs and greater selection effects leading to less, but more productive businesses. We provide descriptive evidence of the spatial distribution of growing early‐stage businesses in Chile that concurs with the theory. We show, first, that while business entry rates increase systematically with the size of a region, the rates of growing early‐stage businesses are not related to the levels of agglomeration. Second, we show that, on the contrary, average early‐stage business productivity, the levels of human capital and business exit rates all relate positively with agglomeration. Third, we estimate regression models that verify the expected relationships between agglomeration factors and regional growing early‐stage‐business activity. The results for Chile suggest that the disadvantages of agglomeration largely offset the benefits, and therefore there is no obvious location penalty to venturing in peripheral areas. Entrepreneurship policies in less‐developed countries should not target excessively to specific industries and regions, as they might curtail an entrepreneurial potential that is ubiquitous.
Health‐related quality of life aspects of the ‘Periodontitis prevalence in ulcerative colitis and Crohn's disease’ (PPCC) cohort
Authors: Bertl Kristina , Tsakos Georgios , Pandis Nikolaos , Bogren Anna , Burisch Johan , Stavropoulos Andreas 
Published: September 2023

AbstractAimTo assess whether oral health problems affect disease‐specific quality of life (QoL) of inflammatory bowel disease (IBD) patients, and vice versa, whether IBD affects oral‐health‐related QoL.Materials and MethodsIndividuals reporting IBD and matched controls were surveyed on general anamnestic information, oral‐health‐related questions and the Oral Health Impact Profile (OHIP)‐5. IBD patients were additionally surveyed on years since diagnosis, disease activity and severity as well as health‐related QoL (Short Inflammatory Bowel Disease Questionnaire, sIBDQ). OHIP‐5 and sIBDQ were defined as primary outcome parameters, and several predictors and confounders were used in adjusted univariable and multivariable regression analyses.ResultsAnswers from 1108 IBD patients and 3429 controls were analysed. Compared with controls, IBD patients reported significantly more frequently an oral impact on daily life and worse oral‐health‐related QoL, with Crohn's disease (CD) patients being more severely affected than ulcerative colitis (UC) patients. The diagnosis of UC and CD, having <20 teeth, severe periodontitis and stressful daily‐life experience were associated with a higher prevalence of poor oral‐health‐related QoL. Among IBD patients, an impaired IBD‐specific, health‐related QoL was significantly associated with the diagnosis of CD and depression, IBD activity and severity, having <20 teeth, presence of oral lesions and stressful daily‐life experience, while a longer time since diagnosis was significantly associated with an improved IBD‐specific, health‐related QoL.ConclusionsThe results of the present study indicate, for the first time, that oral health problems are associated with an impairment of IBD‐specific health‐related QoL, and vice versa, IBD is associated with an impaired oral health‐related QoL. This emphasizes the potential advantages of including dental professionals in the multi‐disciplinary treatment teams of IBD patients.
In vivo method for evaluating sunscreen protection against high‐energy visible light
Authors: Le Digabel J. , Filiol J. , Lauze C. , Redoulès D. , Josse G. 
Published: September 2023

AbstractBackgroundOverexposure to sunlight can have many harmful biological effects on the skin, leading to skin cancer and photoaging. As ultraviolet (UV) radiation has been identified as a cause of DNA damage and oxidative stress in the skin, the photoprotection provided by sunscreens is evaluated through their ability to filter UV light, using the sun protection factor (SPF). However, recent data have shown that high‐energy visible (HEV) light can also cause biological skin damage.ObjectivesTo develop a new in vivo method for evaluating the protection provided by sunscreens across a broad range of wavelengths, including the HEV band, based on multispectral image analysis.MethodsThis study evaluated the absorption properties of six commercially available sunscreens (five SPF 50+ products containing organic UV filters, and one product containing the wide spectrum filter, phenylene bis‐diphenyltriazine [TriAsorB™]) and of a control product containing no filter. Multispectral images were acquired from the skin on the forearms of healthy volunteers, before and after application of the test products. Images taken with LEDs emitting light at wavelengths ranging from UV to infrared were used to generate light reflectance maps for each product. The levels of absorbance of light in the UV and visible bands were then calculated.ResultsThe product containing the wide spectrum filter exhibited significantly higher absorbance over the HEV band (380–450 nm) than the control product and the other commercial sunscreens. All the sunscreens tested showed the same level of absorbance at 365 nm (UVA).ConclusionsMultispectral imaging provides a simple and reliable in vivo method for assessing the real‐world protection provided by sunscreens against all forms of photo‐induced skin damage, including that induced by HEV radiation.
Metformin shows anti‐neoplastic properties by inhibition of oxidative phosphorylation and glycolysis in epidermolysis bullosa‐associated aggressive cutaneous squamous cell carcinoma
Authors: Welponer T. , Weber D. D. , Trattner L. , Tockner B. , Aminzadeh‐Gohari S. , Leb‐Reichl V. , Kaufmann A. , Zauner R. , Wimmer M. , Wally V. , Felder T. K. , Strunk D. , Koller U. , Bauer J. W. , Kofler B. , Guttmann‐Gruber C. , Piñon Hofbauer J. 
Published: September 2023

AbstractBackgroundWhile most cutaneous squamous cell carcinomas (cSCCs) are treatable, certain high‐risk cSCCs, such as those in recessive dystrophic epidermolysis bullosa (RDEB) patients, are particularly aggressive. Owing to repeated wounding, inflammation and unproductive healing, RDEB patients have a 68% cumulative risk of developing life‐threatening cSCCs by the age of 35, and a 70% risk of death by the age of 45. Despite aggressive treatment, cSCC represents the leading cause of premature mortality in these patients, highlighting an unmet clinical need. Increasing evidence points to a role of altered metabolism in the initiation and maintenance of cSCC, making metabolism a potential therapeutic target.ObjectivesWe sought to determine the feasibility of targeting tumour cell energetics as a strategy to selectively hinder the growth advantage of aggressive cSCC.MethodsWe evaluated the cell energetics profiles of RDEB‐SCC cells by analysing available gene expression data against multiple gene signatures and single‐gene targets linked to metabolic reprogramming. Additionally, we employed real‐time metabolic profiling to measure glycolysis and respiration in these cells. Furthermore, we investigated the anti‐neoplastic properties of the metformin against human and murine high‐risk cSCCs in vitro and in vivo.ResultsGene expression analyses highlighted a divergence in cell energetics profiles between RDEB‐SCC and non‐malignant RDEB keratinocytes, with tumour cells demonstrating enhanced respiration and glycolysis scores. Real‐time metabolic profiling supported these data and additionally highlighted a metabolic plasticity of RDEB‐SCC cells. Against this background, metformin exerted an anti‐neoplastic potential by hampering both respiration and glycolysis, and by inhibiting proliferation in vitro. Metformin treatment in an analogous model of fast‐growing murine cSCC resulted in delayed tumour onset and slower tumour growth, translating to a 29% increase in median overall survival.ConclusionsOur data indicate that metformin exerts anti‐neoplastic properties in aggressive cSCCs that exhibit high‐risk features by interfering with respiration and glycolytic processes.
The Patient‐Oriented Scoring of Atopic Dermatitis and SCORAD in young children: New data on interpretability and clinical usefulness
Authors: Barbarot S. , Aubert H. , Stalder J.‐F. , Roye S. , Delarue A. 
Published: September 2023

AbstractBackgroundThere is limited data about the clinical meaningfulness of the Scoring of Atopic Dermatitis (SCORAD) and Patient‐Oriented SCORAD (PO‐SCORAD), particularly in children with mild‐to‐moderate AD. Regular use of patient‐reported outcomes, may deliver more accurate information about the overall health status of AD patients than routine but sparse physician assessments.ObjectiveTo confirm the correlation between SCORAD, PO‐SCORAD, Patient‐Oriented Eczema Measure (POEM) and Investigator's Global Assessment (IGA). To evaluate the interpretability and clinical usefulness of the SCORAD and PO‐SCORAD scores in children.MethodsData were drawn from a 12‐week randomized controlled trial in 335 children, aged 2–6 years, with mainly mild‐to‐moderate AD. Investigators captured SCORAD and IGA at each study visit. Parents used PO‐SCORAD twice‐weekly, and POEM once‐weekly.ResultsThere were strong correlations between PO‐SCORAD and SCORAD (r = 0.874), PO‐SCORAD and POEM (0.734) and PO‐SCORAD and IGA (0.613). The best fit (‘k’ statistic: 0.68) between SCORAD and IGA classes was noted for the following SCORAD categories: <12 (clear/almost clear); 12–25 (mild); and ≥25 (moderate/severe). PO‐SCORAD area under the curve over 8 weeks was significantly greater than that of SCORAD (p = 0.0002), giving a better estimate of disease severity between visits. Patients with a flare within the next 7 days had significantly higher PO‐SCORAD scores 7 days before the flare (p < 0.0001). Moderate erythema was the most significant flare predictor (p < 0.0001).ConclusionPO‐SCORAD is robust and reliable and appears to warrant far greater utility in routine clinical practice than other scores. PO‐SCORAD, used twice‐weekly, may improve the management of patients with AD.
Sharks checking in to the sponge hotel: First internal use of sponges of the genus Agelas and family Irciniidae by banded sand catsharks Atelomycterus fasciatus
Authors: O'Neill Helen L. , White William T. , Pogonoski John J. , Alvarez Belinda , Gomez Oliver , Keesing John K. 
Published: September 2023

AbstractTrawl surveys within and surrounding two northwestern Australian marine parks revealed banded sand catsharks Atelomycterus fasciatus (family Atelomycteridae) taking refuge within large sponges of the family Irciniidae (Demospongiae: Dictyoceratida) and the genus Agelas (Demospongiae: Agelasida: Agelasidae). Five sponges contained a total of 57 A. fasciatus, comprising both sexes and both immature and mature individuals ranging from 102 to 390 mm total length (TL). In the same surveys, only five A. fasciatus were captured unassociated with sponges, suggesting that sponges are an important microhabitat for A. fasciatus and may provide a daytime refuge from predators. A southerly range extension is also reported for this species.