bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extreme transport of light in spheroids of tumor cells
Authors: Pierangeli Davide , Perini Giordano , Palmieri Valentina , Grecco Ivana , Friggeri Ginevra , De Spirito Marco , Papi Massimiliano , DelRe Eugenio , Conti Claudio 
Published: August 2023

AbstractExtreme waves are intense and unexpected wavepackets ubiquitous in complex systems. In optics, these rogue waves are promising as robust and noise-resistant beams for probing and manipulating the underlying material. Localizing large optical power is crucial especially in biomedical systems, where, however, extremely intense beams have not yet been observed. We here discover that tumor-cell spheroids manifest optical rogue waves when illuminated by randomly modulated laser beams. The intensity of light transmitted through bio-printed three-dimensional tumor models follows a signature Weibull statistical distribution, where extreme events correspond to spatially-localized optical modes propagating within the cell network. Experiments varying the input beam power and size indicate that the rogue waves have a nonlinear origin. We show that these nonlinear optical filaments form high-transmission channels with enhanced transmission. They deliver large optical power through the tumor spheroid, and can be exploited to achieve a local temperature increase controlled by the input wave shape. Our findings shed light on optical propagation in biological aggregates and demonstrate how nonlinear extreme event formation allows light concentration in deep tissues, paving the way to using rogue waves in biomedical applications, such as light-activated therapies.
Donor-recipient specificity and age-dependency in fecal microbiota therapy and probiotic resolution of gastrointestinal symptoms
Authors: Wu Qinglong , Boonma Prapaporn , Badu Shyam , Yalcinkaya Nazli , So Sik Yu , Garey Kevin W. , Williams Kent , Arnold L. Eugene , Shulman Robert J. , Kellermayer Richard , Savidge Tor C. 
Published: August 2023

AbstractFecal microbiota transplantation (FMT) has proven to be an effective treatment for recurrent Clostridioides difficile infection (rCDI) in both adult and pediatric patients. However, as microbiome development is a critical factor in children, it remains unclear whether adult fecal donors can provide age-appropriate functional restoration in pediatric patients. To address this issue, we conducted an integrated systems approach and found that concordant donor strain engraftment, along with metabolite restoration, are associated with FMT outcomes in both adult and pediatric rCDI patients. Although functional restoration after FMT is not strain-specific, specialized metabolic functions are retained in pediatric patients when adult fecal donors are used. Furthermore, we demonstrated broad utility of high-resolution variant-calling by linking probiotic-strain engraftment with improved gastrointestinal symptoms in adults with irritable bowel syndrome and in children with autism spectrum disorder. Our findings emphasize the importance of strain-level identification when assessing the efficacy of probiotics and microbiota-based therapeutics.
Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms
Authors: Liu Xiuxiu , Han Maoying , Weng Wendong , Li Yan , Pu Wenjuan , Liu Kuo , Li Xufeng , He Lingjuan , Sun Ruilin , Shen Ruling , He Yulong , Liang Dandan , Chen Yi-Han , Wang Qing-Dong , Tchorz Jan S. , Zhou Bin 
Published: August 2023

AbstractA genetic system, ProTracer, has been recently developed to record cell proliferation in vivo. However, the ProTracer is initiated by an infrequently used recombinase Dre, which limits its broad application for functional studies employing floxed gene alleles. Here we generated Cre-activated functional ProTracer (fProTracer) mice, which enable simultaneous recording of cell proliferation and tissue-specific gene deletion, facilitating broad functional analysis of cell proliferation by any Cre driver.
Fabrication and characterization of microfluidic devices based on boron-modified epoxy resin using CO2 laser ablation for bio-analytical applications
Authors: Mansour Heba , Soliman Emad A. , El-Bab Ahmed M. Fath , Matsushita Yoshihisa , Abdel-Mawgood Ahmed L. 
Published: August 2023

AbstractCO2 laser ablation is a rapid and precise technique for machining microfluidic devices. And also, low-cost epoxy resin (ER) proved the great feasibility of fabricating these devices using the CO2 laser ablation technique in our previous studies. However, such a technique has shown negative impacts on such ER-based microfluidics as rough surface microchannels, and thermal defects. Therefore, incorporating different proportions of boric acid (BA) into epoxy resin formulation was proposed to obviate the genesis of these drawbacks in ER-based microfluidics. The structural and optical properties of plain ER- and B-doped ER-based chips were characterized by Fourier transform infrared (FT-IR) and UV/Vis spectral analyses. Furthermore, their thermal properties were studied by thermo-gravimetric (TGA) and differential scanning calorimetric (DSC) analysis. A CO2 laser ablation machine was used in vector mode to draw the designed micro-channel pattern onto plain ER- and B-doped ER-based chips. The quality of microchannels engraved onto these chips was assessed using 3D laser microscopy. This microscopic examination showed a noticeable reduction in the surface roughness and negligible bulge heights in the laser-ablated micro-channels. On the other hand, overall and specific migration using gravimetric methods and gas chromatography-mass spectrometry (GC–MS), respectively, and PCR compatibility test were performed to explore the convenience of these micro-plates for the biological reactions. These findings validated the applicability of B-doped ER-based microfluidics in bio-analytical applications as a result of the effective role of boric acid in enhancing the thermal properties of these chips leading to get micro-channels with higher quality with no effect on the biological reactions.
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) induces apoptosis in breast cancer cells through inhibiting of Mcl-1 expression
Authors: Kuo Yi-Hsuan , Lai Tsai-Chun , Chang Chia-Hsin , Hsieh Han-Ching , Yang Feng-Ming , Hu Meng-Chun 
Published: August 2023

AbstractThe effective treatment of breast cancer remains a profound clinical challenge, especially due to drug resistance and metastasis which unfortunately arise in many patients. The transcription inhibitor 5,6-dichloro-1-beta-D-ribofuranosyl-benzimidazole (DRB), as a selective inhibitor of cyclin-dependent kinase 9, was shown to be effective in inducing apoptosis in various hematopoietic malignancies. However, the anticancer efficacy of DRB against breast cancer is still unclear. Herein, we demonstrated that administration of DRB to the breast cancer cell line led to the inhibition of cellular proliferation and induction of the typical signs of apoptotic cells, including the increases in Annexin V-positive cells, DNA fragmentation, and activation of caspase-7, caspase-9, and poly (ADP ribose) polymerase (PARP). Treatment of DRB resulted in a rapid decline in the myeloid cell leukemia 1 (Mcl-1) protein, whereas levels of other antiapoptotic proteins did not change. Overexpression of Mcl-1 decreased the DRB-induced PARP cleavage, whereas knockdown of Mcl-1 enhanced the effects of DRB on PARP activation, indicating that loss of Mcl-1 accounts for the DRB-mediated apoptosis in MCF-7 cells, but not in T-47D. Furthermore, we found that co-treatment of MCF-7 cells with an inhibitor of AKT (LY294002) or an inhibitor of the proteasome (MG-132) significantly augmented the DRB-induced apoptosis. These data suggested that DRB in combination with LY294002 or MG-132 may have a greater therapeutic potency against breast cancer cells.
Frequency analysis of the first-overtone RR Lyrae stars based on Extended Aperture Photometry from K2 data
Authors: Netzel H. , Molnár L. , Plachy E. , Benkő J. M. 
Published: August 2023

Context. Additional low-amplitude signals have been observed in many RR Lyrae stars separate from pulsations in radial modes. The most common of these are short-period signals forming a period ratio of around 0.60–0.65 with the first overtone and long-period signals forming a period ratio of around 0.68. The RR Lyrae stars may also exhibit quasi-periodic modulation in their light curves, the so-called Blazhko effect.
Aims. We used the extensive sample of the first-overtone RR Lyrae stars observed by the Kepler telescope during the K2 mission to search for and characterize additional low-amplitude signals. The K2 data provides space-based photometry for a statistically significant sample. Hence, this data is excellent for studying the pulsation properties of RR Lyrae stars in detail.
Methods. We used K2 space-based photometry for RR Lyrae candidates from Campaigns 0–19. We selected RR Lyrae stars pulsating in the first overtone and performed a frequency analysis for each star to characterize their frequency contents.
Results. We classified 452 stars as first-overtone RR Lyrae. From that sample, we selected 281 RR0.61 stars, 67 RR0.68 stars, and 68 Blazhko stars. We found particularly interesting stars that show all of the above phenomena simultaneously. We detected signals in RR0.61 stars that form period ratios lower than those observed for the majority of stars of this type. These signals likely form a new sequence in the Petersen diagram, around a period ratio of 0.60. In 32 stars, we detected additional signals that form a period ratio close to that expected in RRd stars, but the classification of these stars as RRd is uncertain. We also report a discovery of additional signals in eight stars that form a new group in the Petersen diagram around the period ratio of 0.465–0.490. The nature of this periodicity remains unknown.
Gefährliches Zusammenspiel: erhöhtes Lipoprotein(a) bei fortgeschrittener Niereninsuffizienz
Authors: Bernhardt Wanja M. 
Published: August 2023

ZUSAMMENFASSUNGLipoprotein(a) (Lp(a)) ist ein Lipidpartikel, dessen Proteinanteil aus einem Apolipoprotein(a) (Apo(a)) und einem Apolipoprotein B-100 (apoB-100) besteht. Im Wesentlichen ist die Konzentration von Lp(a) im Blut genetisch determiniert. Bei etwas mehr als 20 % der kaukasischen Bevölkerung finden sich erhöhte Lp(a)-Werte (> 50 mg/dl; > 70 nmol/l). Ein erhöhter Lp(a)-Wert ist ein unabhängiger kardiovaskulärer Risikofaktor, der u. a. durch aktuelle Medikamentenentwicklungen zunehmend in den klinischen und therapeutischen Fokus gerät. Insbesondere steigt bei einer erhöhten Lp(a)-Konzentration das Risiko für eine progrediente koronare Herzerkrankung oder eine Aortenklappenstenose. Gleichzeitig nimmt das kardiovaskuläre Risiko aufgrund einer fortgeschrittenen Niereninsuffizienz stark zu. Darüber hinaus führt eine fortgeschrittene Niereninsuffizienz zu negativen Veränderungen des Lipidprofils, einschließlich der Veränderungen der Lp(a)-Konzentration im Blut. Aktuell ist als einzige mögliche Therapieoption für Patienten mit einer klinisch signifikanten Lp(a)-Erhöhung und einer progredienten kardiovaskulären Erkrankung die Durchführung einer therapeutischen Lipoproteinapherese (LA) verfügbar. Die LA senkt bei diesen Patienten erheblich das kardiovaskuläre Risiko. Allerdings existieren zur Epidemiologie und Therapie von Patienten mit einer fortgeschrittenen Niereninsuffizienz und einer erhöhten Lp(a)-Konzentration weniger Daten. In diesem Beitrag wird die Rolle von einem erhöhten Lp(a)-Wert bei einer fortgeschrittenen Niereninsuffizienz ebenso diskutiert wie der gegenseitige Einfluss von einer chronischen Niereninsuffizienz (CKD: „chronic kidney disease“) auf die Lp(a)-Konzentration im Blut. Zudem wird die Evidenzlage und das daraus abzuleitende therapeutische Vorgehen bei einer erhöhten Lp(a)-Konzentration bei einer fortgeschrittenen Niereninsuffizienz dargestellt.
Functional Vascular Anatomy and Arteriovenous Shunts of the Spine
Authors: Ota Takahiro 
Published: August 2023

AbstractThe history of vascular anatomy of the spinal cord and spine began in the late 19th century. With recent advances in endovascular and surgical treatment of vascular lesions of the spinal cord, understanding the vascular anatomy of the spinal cord has become more important than ever. Catheter angiography is the gold standard for diagnosing vascular lesions of the spinal cord, and the vascular architecture of the spinal cord itself is relatively simple, a repetition of basic longitudinal and axial structures. This review discusses the vascular anatomy of the spine and spinal cord from the embryological point of view, as well as an overview of typical spinal arteriovenous shunt diseases mainly depending on their locations: paraspinal, epidural, dural, perimedullary, intramedullary, filum terminale/cauda equina, craniocervical junction, and related diseases.
Measuring the recycling potential of industrial waste for long-term sustainability
Authors: Kanwal Qudsia , Zeng Xianlai , Li Jinhui 
Published: August 2023

AbstractIndustrial waste is the byproduct of many industrial processes. Estimating the recycling potential of industrial waste can help solve the anthropogenic circularity conundrum. Here we employed the Environmental Kuznets Curve (EKC) to verify GDP as a route to "amplified resource efficiency". The results provide substantial evidence for an inverted U and N relationship between the hypothesized GDPPC and industrial waste generation. During 2011–2025, the recycling potential in China showed a downward trend. China is projected to experience a dramatic increase in the production of industrial hazardous waste until the successful implementation of industrial hazardous waste prevention measures reverses the current trends. The turning point of the EKC between industrial waste generation and economic development is around US$8000, while the comprehensive utilization is 102.22 million tons. The EKC inflection points established by the study are correlated with the waste category’s turning point. The revised EKC claims that technological change may accelerate the turning points; thus, the graph shifts downward and right. The study recommends investing in new technology development to help the industry produce virgin and recycled industrial waste for a circular economy. Recycling potential evaluation also assists us to achieve our Sustainable Development Goals (SDGs).
Comparability strategy and demonstration for post-approval production cell line change of a bevacizumab biosimilar IBI305
Authors: Wu Zhouyi , Xu Gangling , He Wu , Yu Chuanfei , Huang Wanqiu , Zheng Shirui , Kang Dian , Xie Michael H , Cao Xingjun , Wang Lan , Wei Kaikun 
Published: August 2023

Abstract
High-producing cell line could improve the affordability and availability of biotherapeutic products. A post-approval production cell line change, low-titer CHO-K1S to high-titer CHO-K1SV GS-KO, was performed for a China marketed bevacizumab biosimilar IBI305. Currently, there is no regulatory guideline specifically addressing the requirements for comparability study of post-approval cell line change, which is generally regarded as the most complex process change for biological products. Following the quality by design principle and risk assessment, an extensive analytical characterization and three-way comparison was performed by using a panel of advanced analytical methods. Orthogonal and state-of-the-art techniques including nuclear magnetic resonance and high-resolution mass spectrometry were applied to mitigate the potential uncertainties of higher-order structures and to exclude any new sequence variants, scrambled disulfide bonds, glycan moiety and undesired process-related impurities such as host cell proteins. Nonclinical and clinical pharmacokinetics (PK) studies were conducted subsequently to further confirm the comparability. The results demonstrated that the post-change IBI305 was analytically comparable to the pre-change one and similar to the reference product in physicochemical and biological properties, as well as the degradation behaviors in accelerated stability and forced degradation studies. The comparability was further confirmed by comparable PK, pharmacodynamics, toxicological and immunogenicity profiles of nonclinical and clinical studies. The comparability strategy presented here might extend to cell line changes of other post-approval biological products, and particularly set a precedent in China for post-approval cell line change of commercialized biosimilars.
Dynamic scheduling of market price-based combined heat–power-constrained renewable microgrid
Authors: Shukla Sunita , Pandit Manjaree 
Published: August 2023

Abstract
In this paper, a market price-based combined heat–power dynamic dispatch model for a microgrid is presented. The microgrid comprises cogeneration units and wind and solar power-generation units. A battery and a heat storage tank are incorporated to optimally balance variations in heat-and-power load demands. The proposed model explores the impact of market prices of electricity, heat supply and load variability on the optimal schedule such that profit maximizes and emission, loss and waste heat are minimized. The Weibull probability distribution function is applied to characterize the uncertain renewable power variable in the model and to find the over- and under-scheduling costs. The problem is solved using an improved differential evolution algorithm in which a fuzzy membership module is appended to obtain a solution having the highest attainment for the selected multiple objectives. The results show that the proposed model can handle uncertain heat–power demand and price scenarios to produce feasible and optimal schedules with owner profits, heat utilization and renewable share varying between 10.55–115.97%, 72.51–90.39% and 26.82–38.05%, respectively.
Optimal numerical integration and approximation of functions on ℝd equipped with Gaussian measure
Authors: Dũng Dinh , Kien Nguyen Van 
Published: August 2023

Abstract
We investigate the numerical approximation of integrals over $\mathbb{R}^{d}$ equipped with the standard Gaussian measure $\gamma $ for integrands belonging to the Gaussian-weighted Sobolev spaces $W^{\alpha }_{p}(\mathbb{R}^{d}, \gamma )$ of mixed smoothness $\alpha \in \mathbb{N}$ for $1 &lt; p &lt; \infty $. We prove the asymptotic order of the convergence of optimal quadratures based on $n$ integration nodes and propose a novel method for constructing asymptotically optimal quadratures. As for related problems, we establish by a similar technique the asymptotic order of the linear, Kolmogorov and sampling $n$-widths in the Gaussian-weighted space $L_{q}(\mathbb{R}^{d}, \gamma )$ of the unit ball of $W^{\alpha }_{p}(\mathbb{R}^{d}, \gamma )$ for $1 \leq q &lt; p &lt; \infty $ and $q=p=2$.
Rancière, music, and the musicality of teaching
Authors: Rytzler Johannes 
Published: August 2023

Abstract
While the aesthetics of Rancière is a well-explored topic, there has been something missing from the reception of his works, and that is the relation between Rancière’s aesthetics and music. However, in recent years an interest in this relation has resulted in several academic contributions, which is sign enough that there is in fact a musical element in his works. Rancière himself, in response to this reception, has acknowledged as much. Music is a human form of expression that uses the physicality of air to produce vibrations that encounter and resonate with the human body. Musicality is the ability to attend to such vibrations and harness the expectations and surprises that they bring about. In this article, I explore how a musical approach to Rancière’s writings can inform educational philosophy, especially as regards the practice of teaching. Particular attention is paid to his notion of the sensorium as a sensible realm where we experience and encounter difference and otherness, in political events as well as in teaching situations. Attending ethically to these situations is predicated on a certain sensibility that involves certain aesthetic qualities. In this article, I explore this sensibility as a particular educational musicality. Drawing from educational philosophy, the aesthetic theory of Jacques Rancière, and music philosophy, I connect this musicality of teaching to an ability to navigate in an ethical space that comes to life through a material/sensible community of interests formed in teaching practice. I use the term acousmatic experience as an explorative device in an attempt to depict teaching practice as something that can bring about a specific educational sensorium.
Colossal transverse magnetoresistance due to nematic superconducting phase fluctuations in a copper oxide
Authors: Wårdh Jonatan , Granath Mats , Wu Jie , Bollinger Anthony T , He Xi , Božović Ivan 
Published: August 2023

Abstract
Electronic anisotropy (“nematicity”) has been detected in cuprate superconductors by various experimental techniques. Using angle-resolved transverse resistance (ARTR) measurements, a very sensitive and background-free technique that can detect 0.5% anisotropy in transport, we have observed it also in La2-xSrxCuO4 (LSCO) for 0.02 ≤ x ≤ 0.25. A central enigma in LSCO is the rotation of the nematic director (orientation of the largest longitudinal resistance) with temperature; this has not been seen before in any material. Here, we address this puzzle by measuring the angle-resolved transverse magnetoresistance (ARTMR) in LSCO. We report the discovery of colossal transverse magnetoresistance (CTMR)—an order-of-magnitude drop in the transverse resistivity in the magnetic field of 6 T. We show that the apparent rotation of the nematic director is caused by anisotropic superconducting fluctuations, which are not aligned with the normal electron fluid, consistent with coexisting bond-aligned and diagonal nematic orders. We quantify this by modeling the (magneto-)conductivity as a sum of normal (Drude) and paraconducting (Aslamazov–Larkin) channels but extended to contain anisotropic Drude and Cooper-pair effective mass tensors. Strikingly, the anisotropy of Cooper-pair stiffness is much larger than that of the normal electrons. It grows dramatically on the underdoped side, where the fluctuations become quasi-one-dimensional. Our analysis is general rather than model dependent. Still, we discuss some candidate microscopic models, including coupled strongly-correlated ladders where the transverse (interladder) phase stiffness is low compared with the longitudinal intraladder stiffness, as well as the anisotropic superconducting fluctuations expected close to the transition to a pair-density wave state.