bluuebunny/crossref_metadata_2025_split huggingface dataset:
Counterintuitive Concepts Across Domains: A Unified Phenomenon?
Authors: Sommer Joseph , Musolino Julien , Hemmer Pernille 
Published: April 2023

AbstractThe minimally counterintuitive (MCI) thesis in the cognitive science of religion proposes that supernatural concepts are prevalent across cultures because they possess a common structure—namely, violations of intuitive ontological assumptions that facilitate concept representation. These violations are hypothesized to give supernatural concepts a memorability advantage over both intuitive concepts and “maximally counterintuitive” (MXCI) concepts, which contain numerous ontological violations. However, the connection between MCI concepts and bizarre (BIZ) but not supernatural concepts, for which memorability advantages are predicted by the von Restorff (VR) effect, has been insufficiently clarified by earlier research. Additionally, the role of inferential potential (IP) in determining MCI concepts’ memorability has remained vague and only rarely controlled for. In a pre‐registered experiment, we directly compare memorability for MCI and MXCI concepts, compared to BIZ concepts, while controlling for IP as well as degree of bizarreness. Results indicate that when IP and bizarreness are controlled for, memorability of counterintuitive and BIZ concepts—relative to intuitive control concepts—is similar across concepts with one, two, and three characteristics. Findings suggest that the MCI and VR effects may be manifestations of the same underlying mechanisms.
Morphologic and immunophenotypic evaluation of liver allograft biopsies with contemporaneous serum DSA measurements
Authors: El Hag Mohamed I. , Kaneku Hugo , Jorgensen Dana , Zeevi Adriana , Stevenson Heather L. , Yadak Nour , Hassan Mohamed , Du Xiaotang , Demetris Anthony J. 
Published: April 2023

AbstractBackgroundAcute antibody mediated rejection is increasingly identified in liver allografts as a unique form of alloimmune injury associated with donor specific antibodies (DSA). This manifests pathologically as microvascular injury and C4d uptake. Despite the liver allograft's relative resistance to alloimmune injury, liver allografts are not impervious to cellular and antibody‐mediated rejection.MethodsIn this blinded control study, we evaluated CD163 immunohistochemistry and applied the Banff 2016 criteria for diagnosis of acute AMR on a group of indication allograft liver biopsies from DSA positive patients and compared them to indication biopsies from DSA negative controls.ResultsMost DSA positive patients were females (75%, p = .027), and underwent transplantation for HCV infection. Significant histopathological predictors of serum DSA positivity were Banff H‐score (p = .01), moderate to severe cholestasis (p = .03), and CD163 score > 2 (p = .029). Other morphologic features that showed a trend with DSA positivity include Banff portal C4d‐score (p = .06), bile ductular reaction (p = .07), and central perivenulitis (p = .07). The odds of DSA sMFI ≥5000 was 12.5 times higher in those with a C4d score >1 than those with a C4d score ≤ 1 (p = .04). Incidence of definite for aAMR in the DSA positive cohort was 25% (n = 5), and 0% in the DSA negative cohort. A group of 5 DSA positive cases were not classifiable by the current scheme.ConclusionSinusoidal CD163, Banff H‐score, and diffuse C4d are predictors of serum DSA, and facilitate recognition of histopathological features associated with serum DSA and tissue–antibody interaction.
Live imaging observation of elevation of the anterior palatal shelf in mouse embryos
Authors: Nagasaka Arata , Sakiyama Koji , Bando Yasuhiko , Onozawa Go , Amano Osamu 
Published: April 2023

AbstractThe mammalian secondary palate develops through complex processes including palatal shelf growth, elevation, and fusion. Palatal shelf elevation is a process accompanied by large‐scale morphological changes over a short period. The elevation pattern changes along the anterior–posterior axis; the anterior region elevates by the “flip‐up” model, and the middle and posterior regions reorient through the “flow” model. However, the mechanisms of both models are unclear because of the rapid progression of the elevation in utero. To observe palatal elevation in real time in detail, we aimed to establish a live imaging method using explants of the anterior region of the palatal shelf in mouse embryos before the beginning of elevation. Changes in the degree of shelf orientation were measured, which showed that the palatal shelf continuously changed shape toward the lingual side. The changes in the angle between the lingual and buccal bases of the palatal shelf were different; the morphological change at the lingual side resulted in a more acute angle, and the change at the buccal side resulted in a more obtuse angle. The morphological changes of the lingual and buccal sides occurred nearly simultaneously, suggesting that the anterior region of the palatal shelf in vitro elevated according to the “flip‐up” model. This live imaging method enables the continuous observation of palatal shelf elevation and provides new insights into palatogenesis.
Comparison of efficacy and safety between third‐dose triple and third‐dose dual antihypertensive combination therapies in patients with hypertension
Authors: Sung Ki‐Chul , Hong Soon Jun , Rhee Moo‐Yong , Jeong Myung‐Ho , Kim Dae‐Hee , Lim Sang‐Wook , Park Kyungil , Lee Jin Bae , Kim Seok‐Yeon , Cho Jin‐Man , Cho Goo‐Yeong , Heo Jung‐Ho , Kim Sang‐Hyun , Lee Hae‐Young , Kim Weon , Cho Deok‐Kyu , Park Sungha , Shin Jinho , Pyun Wook‐Bum , Kwon Kihwan , Rha Seung‐Woon , Jung Jin‐A 
Published: April 2023

AbstractWe compared the efficacy and safety of third‐standard‐dose triple and third‐standard‐dose dual antihypertensive combination therapies in patients with mild to moderate hypertension. This was a phase II multicenter, randomized, double‐blind, parallel‐group trial. After a 4‐week placebo run‐in period, 245 participants were randomized to the third‐dose triple combination (ALC group; amlodipine 1.67 mg + losartan potassium 16.67 mg + chlorthalidone 4.17 mg) or third‐dose dual combination (AL group; amlodipine 1.67 mg + losartan potassium 16.67 mg, LC group; losartan potassium 16.67 mg + chlorthalidone 4.17 mg, AC group; amlodipine 1.67 mg + chlorthalidone 4.17 mg) therapy groups and followed up for 8 weeks. The mean systolic blood pressure (BP) reduction was ‐18.3 ± 13.2, ‐13.0 ± 13.3, ‐16.3 ± 12.4, and ‐13.8 ± 13.2 mmHg in the ALC, AL, LC, and AC groups, respectively. The ALC group showed significant systolic BP reduction compared to the AL and AC groups at weeks 4 (P = .010 and P = .018, respectively) and 8 (P = .017 and P = .036, respectively). At week 4, the proportion of systolic BP responders was significantly higher in the ALC group (42.6%) than in the AL (22.0%), LC (23.3%), and AC (27.1%) groups (P = .013, P = .021, and P = .045, respectively). At week 8, the proportion of systolic and diastolic BP responders was significantly higher in the ALC group (59.7%) than in the AL (39.3%) and AC (42.4%) groups (P = .022 and P = .049, respectively) at week 8. Third‐standard‐dose triple antihypertensive combination therapy demonstrated early effective BP control compared to third‐standard‐dose dual combination therapies, without increasing adverse drug reactions in patients with mild‐to‐moderate hypertension.
Pharmacokinetic, sedative, and physiological effects of oral compounded formulations of trazodone alone or in combination with gabapentin in male cats
Authors: Tucker Laura E. , Sanchez Andrea , Valverde Alexander , Blois Shauna , Uccello Olivia , Rutherford Ashley , Monteith Gabrielle , Reinhart Jennifer M. , Keating Stephanie , Gu Yu , Johnson Ron 
Published: April 2023

AbstractTrazodone and gabapentin are common oral sedatives in cats, used alone or combined, but no pharmacokinetic studies exist for trazodone in this species. The objective of this study was to determine the pharmacokinetics of oral trazodone (T) alone, or in combination with gabapentin (G) in healthy cats. Cats (n = 6) were randomly allocated to receive T (3 mg/kg) intravenously (IV), T (5 mg/kg) orally (PO), or T (5 mg/kg) and G (10 mg/kg) PO with a 1‐week washout period between treatments. Heart rate, respiratory rate, indirect blood pressure, and level of sedation were assessed, and venous blood samples were collected serially over 24 h. Analysis of plasma trazodone concentration was performed using liquid chromatography–tandem mass spectrometry (LC–MS/MS). Oral T administration resulted in a bioavailability of 54.9(7–96)%, and 17.2(11–25)% when administered with G. Tmax 0.17 (0.17–0.5) and 0.17 (0.17–0.75) h; Cmax 1.67 ± 0.91 and 1.22 ± 0.54 μg/mL, AUC 5.23 (2.0–18.76) and 2.37 (1.17–7.80) h*μg/mL; T1/2 5.12 ± 2.56 and 4.71 ± 1.07 h; for T and TG, respectively. Sedation was significant when compared to baseline in all groups from 20 or 45 min to 8 h indicating some lag between peak plasma concentration and sedative effects. Physiological variables remained within normal limits. This study concludes that oral trazodone is rapidly absorbed in healthy cats. Addition of gabapentin did not result in more profound sedation, showing no clinical advantage of combining these drugs in this study population.
An umbrella review of the effectiveness of fiscal and pricing policies on food and non‐alcoholic beverages to improve health
Authors: Barry Luke E. , Kee Frank , Woodside Jayne , Clarke Mike , Cawley John , Doherty Edel , Crealey Grainne E. , Duggan Jim , O'Neill Ciaran 
Published: April 2023

SummaryPoor quality diets represent major risk factors for the global burden of disease. Modeling studies indicate a potential for diet‐related fiscal and pricing policies (FPs) to improve health. There is real‐world evidence (RWE) that such policies can change behavior; however, the evidence regarding health is less clear. We conducted an umbrella review of the effectiveness of FPs on food and non‐alcoholic beverages in influencing health or intermediate outcomes like consumption. We considered FPs applied to an entire population within a jurisdiction and included four systematic reviews in our final sample. Quality appraisal, an examination of excluded reviews, and a literature review of recent primary studies assessed the robustness of our results. Taxes and, to some extent, subsidies are effective in changing consumption of taxed/subsidized items; however, substitution is likely to occur. There is a lack of RWE supporting the effectiveness of FPs in improving health but this does not mean that they are ineffective. FPs may be important for improving health but their design is critical. Poorly designed FPs may fail to improve health and could reduce support for such policies or be used to support their repeal. More high‐quality RWE on the impact of FPs on health is needed.
Luck egalitarianism and non‐overlapping generations
Authors: Finneron‐Burns Elizabeth 
Published: April 2023

AbstractThis paper argues that there are good reasons to limit the scope of luck egalitarianism to co‐existing people. First, I outline reasons to be sceptical about how “luck” works intergenerationally and therefore the very grounding of luck egalitarianism between non‐overlapping generations. Second, I argue that what Kasper Lippert‐Rasmussen calls the “core luck egalitarian claim” allows significant intergenerational inequality which is a problem for those who object to such inequality. Third, luck egalitarianism cannot accommodate the intuition that it might be required to leave future generations better off than we are, even if it would come at no cost to ourselves. Finally, I argue that following another, broader, version of luck egalitarianism would require us to level down future generations and possibly even ourselves, which is a problem for those persuaded by the levelling‐down objection.
Habitabilidad de las mujeres desplazadas por la violencia en Colombia: caso de La Primavera
Authors: Valencia Londoño Paula Andrea , Valencia Londoño Diana 
Published: April 2023

La vida cotidiana de las mujeres ha sido moldeada por los espacios en que habitan (Soto, 2018); y en particular, esto es aplicable a la vida de las mujeres desplazadas por la violencia en Colombia. En tal sentido, este artículo pretende comprender los determinantes de género que subyacen a las condiciones de habitabilidad de estas mujeres y que delimitan su derecho a la ciudad. Para ello, se hace uso de los datos desagregados por género de una encuesta sobre habitabilidad aplicada a 72 cabezas de hogar (46 mujeres y 25 hombres), del asentamiento La Primavera. El análisis de los determinantes de género en tres escenarios: vivienda, espacio público y equipamientos y amenaza y riesgo de desastres, permite afirmar que dichos determinantes se ven exacerbados por las afectaciones derivadas del conflicto armado, pero en contrapartida, las mujeres incrementan los esfuerzos para mejorar sus condiciones de habitabilidad en comparación con sus pares masculinos
Supplemental Material: Cenozoic slip along the southern Sierra Nevada normal fault, California (USA): A long-lived stable western boundary of the Basin and Range
Authors: Lee J. , al. et 
Published: April 2023

<p> Figure 1 is interactive. Maps, labels, and data sets for this figure are organized in a series of layers that may be viewed separately or in combination using the capabilities of the Acrobat (PDF) layering function (click “Layers” icon along vertical bar on left side of window for display of available layers, or turn layers on or off by clicking the box that encompasses the layer label located within the gray box in the lower right corner of the map).</p>
<p>Figure 7 is interactive. Graph, labels, and data sets for this figure are organized in a series of layers that may be viewed separately or in combination using the capabilities of the Acrobat (PDF) layering function (click “Layers” icon along vertical bar on left side of window for display of available layers, and/or tturn layers on or off by clicking the box that encompasses the layer label located within the gray box beneath the plot). </p>
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Minimal resilience and insurgent conflict: qualitative analysis of the resilience process in six primary health centres in central Mali
Authors: Lerosier Thomas , Touré Laurence , Diabaté Seydou , Diarra Yacouba , Ridde Valery 
Published: April 2023

BackgroundIn the context of universal health coverage in the Sahel, the study focuses on primary health centres and the difficulties of their implementation in the context of insurgency conflicts in central Mali.MethodsThis is qualitative research through a multiple case study. We selected six health centres according to a reasoned choice to bring together contrasting situations. We conducted 96 semistructured interviews and consulted secondary quantitative data on attendance. By focusing on community health centres, the conceptual approach focuses on the process of resilience that unfolds in a dual context of chronic health system dysfunctions and armed conflict.ResultsThe resilience strategies deployed by health professionals were relatively basic and uncoordinated. In the end, it was the individuals who showed absorption. However, their room for manoeuvre was limited. In the most isolated health centres, resilience was based on subordinate, poorly trained staff, often from the locality. Degraded working conditions and fear caused a form of resignation among health workers.ConclusionThe strategies and resources used showed a form of minimal resilience. This form is unfolding in a context marked by two structuring features. On the one hand, the Malian health system was relatively dysfunctional before the crisis, and on the other hand, the type of conflict was relatively low intensity that allowed health centres to remain open.
Observational analysis of documentation burden and data duplication in trauma patient pathways at a major trauma centre
Authors: Ludley Alistair , Ting Andrew , Malik Dean , Sivanadarajah Naveethan 
Published: April 2023

ObjectivesTrauma patients require extensive documentation across paper and electronic modalities. The objectives of this study were (1) to assess the documentation burden for trauma patients by contrasting entries against predetermined key information elements, dubbed ‘data entry points’ (DEPs) of a thorough trauma clerking, and by evaluating completeness of entries; and (2) to assess documentation for repetition using a Likert scale and through identification of copied data elements.MethodsA 1-month retrospective observational pilot study analysing documentation within the first 24 hours of a patient’s presentation to a major trauma centre. Documentation was analysed across three platforms: paper notes, electronic health record (EHR) and patient organisation system (POS) entries. Entries were assessed against predetermined DEPs, for completeness, for directly copied elements and for uniqueness (using a Likert scale).Results30 patients were identified. The mean completeness of a clerking on paper, EHR and POS was 79%, 70% and 62%, respectively. Mean completeness decreased temporally down to 41% by the second ward round. The mean proportion of documented DEPs on paper, EHR and POS entries was 47%, 49% and 35%, respectively. 77% of POS entries contained copied elements, with a low level of uniqueness of 1.3/5.DiscussionOur results show evidence of high documentation burden with unnecessary repetition of data entry in the management of trauma patients.ConclusionThis pilot study of trauma patient documentation demonstrates multiple inefficiencies and a marked administrative burden, further compounded by the need to document across multiple platforms, which may lead to eventual patient safety concerns.
Prospective Analysis Reveals Associations between Carbohydrate Intakes, Genetic Predictors of Short-Chain Fatty Acid Synthesis, and Colorectal Cancer Risk
Authors: Watling Cody Z. , Kelly Rebecca K. , Murphy Neil , Gunter Marc , Piernas Carmen , Bradbury Kathryn E. , Schmidt Julie A. , Key Timothy J. , Perez-Cornago Aurora 
Published: April 2023

AbstractWhole grain and fiber intakes may decrease the risk of colorectal cancer. The interplay between host genetic factors, colonization of specific bacteria, production of short-chain fatty acids (SCFA), and intake of whole grains and fiber could alter the protective role of carbohydrates against colorectal cancer. Here, we assessed intakes of types and sources of carbohydrates in 114,217 UK Biobank participants with detailed dietary data (2–5 24-hour dietary assessments), and a host polygenic score (PGS) was applied to categorize participants as high or low for intraluminal microbial SCFA production, namely, butyrate and propionate. Multivariable Cox proportional hazards models were used to determine the associations of carbohydrates and SCFA with colorectal cancer incidence. During a median follow-up of 9.4 years, 1,193 participants were diagnosed with colorectal cancer. Risk was inversely associated with intakes of non-free sugar and whole grain fiber. Evidence of heterogeneity was observed by the butyrate PGS; consuming higher amounts of whole grain starch was only associated with a lower risk of colorectal cancer in those with predicted high SCFA production. Similarly, in additional analyses utilizing the larger UK Biobank cohort (N = 343,621) with less detailed dietary assessment, only individuals with a high genetically predicted butyrate production had a lower risk of colorectal cancer per 5 g/day intake of bread and cereal fiber. This study suggests that colorectal cancer risk varies by intake of carbohydrate types and sources, and the impact of whole grain intake may be modified by SCFA production.Significance:Prospective population-level analyses provide evidence supporting the importance of butyrate production in reduction of colorectal cancer risk by whole grain consumption.
C

ombination

A

TR (ceralasertib) and

P

A

R

P (olaparib)

I

nhibitor (CAPRI) Trial in Acquired PARP Inhibitor–Resistant Homologous Recombination–Deficient Ovarian Cancer
Authors: Wethington Stephanie L. , Shah Payal D. , Martin Lainie , Tanyi Janos L. , Latif Nawar , Morgan Mark , Torigian Drew A. , Rodriguez Diego , Smith Simon A. , Dean Emma , Domchek Susan M. , Drapkin Ronny , Shih Ie-Ming , Brown Eric J. , Hwang Wei-Ting , Armstrong Deborah K. , Gaillard Stephanie , Giuntoli Robert , Simpkins Fiona 
Published: April 2023

Abstract

Purpose:
Addition of ataxia telangiectasia and Rad3-related kinase inhibitors (ATRi) to PARP inhibitors (PARPi) overcomes PARPi resistance in high-grade serous ovarian cancer (HGSOC) cell and mouse models. We present the results of an investigator-initiated study of combination PARPi (olaparib) and ATRi (ceralasertib) in patients with acquired PARPi-resistant HGSOC.

Patients and Methods:
Eligible patients had recurrent, platinum-sensitive BRCA1/2 mutated or homologous recombination (HR)–deficient (HRD) HGSOC and clinically benefited from PARPi (response by imaging/CA-125 or duration of maintenance therapy; &gt; 12 months first-line or &gt; 6 months ≥ second-line) before progression. No intervening chemotherapy was permitted. Patients received olaparib 300 mg twice daily and ceralasertib 160 mg daily on days 1 to 7 of a 28-day cycle. Primary objectives were safety and objective response rate (ORR).

Results:
Thirteen patients enrolled were evaluable for safety and 12 for efficacy; 62% (n = 8) had germline BRCA1/2 mutations, 23% (n = 3) somatic BRCA1/2 mutations, and 15% (n = 2) tumors with positive HRD assay. Prior PARPi indication was treatment for recurrence (54%, n = 7), second-line maintenance (38%, n = 5) and first-line treatment with carboplatin/paclitaxel (8%, n = 1). There were 6 partial responses yielding an ORR of 50% (95% confidence interval, 0.15–0.72). Median treatment duration was 8 cycles (range 4–23+). Grade (G) 3/4 toxicities were 38% (n = 5); 15% (n = 2) G3 anemia, 23% (n = 3) G3 thrombocytopenia, 8% (n = 1) G4 neutropenia. Four patients required dose reductions. No patient discontinued treatment due to toxicity.

Conclusions:
Combination olaparib and ceralasertib is tolerable and shows activity in HR-deficient platinum-sensitive recurrent HGSOC that benefited and then progressed with PARPi as the penultimate regimen. These data suggest that ceralasertib resensitizes PARPi-resistant HGSOCs to olaparib, warranting further investigation.