bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and patterns of premenstrual disorders and possible association with sexual harassment: a cross-sectional study of young Arab women
Authors: AbdelQadir Yossef Hassan , Assar Ahmed , Abdelghafar Yomna Ali , Kamal Manar Ahmed , Zaazouee Mohamed Sayed , Elsayed Sarah Makram , Ragab Khaled Mohamed , Nabhan Ayman Essa , Gamaleldin Nahla Ahmed ,   IMedRA collaborators team, Moris Mariam Salah , AL-Masri Batool Emad , El-Sherif Dina M. , Mohamed Goudy Yomna , Khaled Alsiouty Asmaa , Mahmoud Maysa Madny , Faragalla Hazem Metwally , Abdelazim Ebtehal Ahmed , Mohamed Nadine Abdel-Hamied , Elsayed Sarah Ibrahim , Shehata Hala Hassan , Hasan Sara Mohamed , Mahmoud Rana Hanafy , Fathy Israa Ashraf , Gomaa Eman Mohamed , Ezz Sara Abdallah , Alqatawneh Dana , Hrezat Yasmin Salah , Alhefnawi Kawther Saleem , Hasan Lina Omar , Saleh Hadeel Naem , Abed Ayah AbdElWaley , Rashed Tharwah Mohammad , Ikhlaif Nedaa Yousef Ahmad , Bashir Rand Adnan , Alrosan Sallam Mohammad , Ayyoub Merana khalil , Labeeb Muna Mowafaq , AbuShanab Orjuwan Omar , Fraihat Noor Y. , Al Jabban Haya , Ahdab Amina , Alolabi Homam , Al Khalil Sandy Adel , klib Mohamad , Azzouz Wisam , Allazkani Inas A. Haza’a , Wannes Lana Talal , Naem Maya Abdullah , Al Barudi Nada M. Molham , Alassi Shatha , Tarabishi Joudi Saadeddin , Anadani Rami , Hamoud Hasan M. Masoum 
Published: December 2022

Abstract
Background
Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) represent a range of both psychiatric and physical symptoms that impair quality of life and interfere with daily activities in females.

Aims
To assess the prevalence of PMS and PMDD in Egypt, Jordan and Syria, its demographic associations and the potential link to sexual harassment (SH).

Methods
We used an Arabic version of the premenstrual symptoms screening tool (PSST) to assess the prevalence of PMS and PMDD. Another two-part questionnaire was used to assess the harassment experience.

Results
22,021 women agreed to fill the questionnaire; the majority (65%) aged 18–25 years old. PMS was more prevalent in Egyptian women 77.7% followed by women from Jordan 72.9% then Syria 66.3%. PMDD prevalence followed the same order (40%, 34.7% and 28.2%). Both conditions were significantly associated with obesity and working in medical careers (P = .001). 5733 women agreed to share their sexual harassment experience. Results showed a significant association between the diversity and frequency of sexual harassment and the frequency of the pre-menstrual conditions, PMS Frequency was 87.6%, 80.7% and 78% in participants who were harassed on daily basis Vs. once weekly or monthly vs. few times in their lifetime (p = .04). A similar statistically significant difference was noticed regarding having PMDD (66.4% vs. 47.6% vs. 42.5%).

Conclusion
The study showed high levels of both PMS and PMDD. The data provided by this study also sheds light on a potential link between SH and developing Pre-menstrual disorders.
Effect of medical researchers’ creative performance on scientific misconduct: a moral psychology perspective
Authors: Zhang Na , Guo Mingxuan , Jin Chunhua , Xu Zhen 
Published: December 2022

Abstract
Background
In recent years, some researchers have engaged in scientific misconduct such as fabrication, falsification, and plagiarism to achieve higher research performance. Considering their detrimental effects on individuals’ health status (e.g., patients, etc.) and extensive financial costs levied upon healthcare systems, such wrongdoings have even more salience in medical sciences. However, there has been little discussion on the possible influence of medical researchers’ existing creative performance on scientific misconduct, and the moral psychological mechanisms underlying those effects are still poorly understood.

Methods
We build a moderated mediation model to test how medical researchers’ creative performance affects their scientific misconduct and explore the role of moral licensing and moral identity in this process. Based on situational experiments and projection techniques, 287 medical researchers in China participated in a survey.

Results
Medical researchers’ creative performance positively relates to scientific misconduct, and moral licensing plays a mediating role in the relationship between them. In addition, moral identity has a negative moderating effect on the mediating effect of moral licensing on creative performance and scientific misconduct.

Conclusion
Moral licensing plays a fully mediating role in the relationship between creative performance and scientific misconduct. And moral identity negatively moderates the indirect effect of creative performance on scientific misconduct through moral licensing. The findings provide theoretical and practical implications for the prevention of medical researchers’ scientific misconduct.
An international survey of the structure and process of care for traumatic spinal cord injury in acute and rehabilitation facilities: lessons learned from a pilot study
Authors: Abedi Aidin , Biering-Sørensen Fin , Chhabra Harvinder S. , D’Andréa Greve Julia Maria , Khan Nasser M. , Koskinen Eerika , Kwan Kenny Yat Hong , Liu Nan , Middleton James W. , Moslavac Sasa , Rahimi-Movaghar Vafa , O’Connell Colleen , Previnaire Jean G. , Patel Alpesh , Scivoletto Giorgio , Sharwood Lisa N. , Townson Andrea , Urquhart Susan , Vainionpää Aki , Zaman Atiq Uz , Noonan Vanessa K. , Cheng Christiana L. 
Published: December 2022

Abstract
Background
To describe the key findings and lessons learned from an international pilot study that surveyed spinal cord injury programs in acute and rehabilitation facilities to understand the status of spinal cord injury care.

Methods
An online survey with two questionnaires, a 74-item for acute care and a 51-item for rehabilitation, was used. A subset of survey items relevant to the themes of specialized care, timeliness, patient-centeredness, and evidence-based care were operationalized as structure or process indicators. Percentages of facilities reporting the structure or process to be present, and percentages of indicators met by each facility were calculated and reported separately for facilities from high-income countries (HIC) and from low and middle-income countries (LMIC) to identify “hard to meet” indicators defined as those met by less than two-thirds of facilities and to describe performance level.

Results
A total of 26 acute and 26 rehabilitation facilities from 25 countries participated in the study. The comparison of the facilities based on the country income level revealed three general observations: 1) some indicators were met equally well by both HIC and LMIC, such as 24-hour access to CT scanners in acute care and out-patient services at rehabilitation facilities; 2) some indicators were hard to meet for LMIC but not for HIC, such as having a multidisciplinary team for both acute and rehabilitation settings; and 3) some indicators were hard to meet by both HIC and LMIC, including having peer counselling programs. Variability was also observed for the same indicator between acute and rehabilitation facilities, and a wide range in the total number of indicators met among HIC facilities (acute 59–100%; rehabilitation 36–100%) and among LMIC facilities (acute: 41–82%; rehabilitation: 36–93%) was reported.

Conclusions
Results from this international pilot study found that the participating acute and rehabilitation facilities on average adhered to 74% of the selected indicators, suggesting that the structure and processes to provide ideal traumatic spinal cord injury care were broadly available. Recruiting a representative sample of SCI facilities and incorporating regional attributes in future surveys will be helpful to examine factors affecting adherence to indicators.
A doctor-nurse-patient mobile health management system effectively controls blood glucose in chinese patients with type 2 diabetes mellitus: a prospective study
Authors: Tan Xiaoqing , Qi Zonghai , Chen Ling , Li Dongmin , Cai Xiangyin , Song Yi , Liu Yajie 
Published: December 2022

Abstract
Background
Coronavirus-2019 pandemic in China aroused increasing interest in telemedicine-supported glycaemic control. We hypothesize that age might influence usage and efficacy of telemedicine-supported glycaemic control. This study aims to measure the effects of a doctor-nurse-patient Mobile Health Management System (MHMS) for fasting plasma glucose (FPG) control in patients with type 2 diabetes mellitus (T2DM).

Methods
Four hundred sixty four patients with T2DM were recruited. A one-hour diabetes education provided to each patient and subsequent follow-ups arranged in the 1st, 2nd, 4th, 8th, and 12th week after enrollment were recorded in MHMS. The effectiveness of MHMS was defined as the proportion of patients achieving FPG target (below 126 mg/dL or 7.0mml/L).

Results
Among the enrolled 464 patients (age: 55.0 ± 13.7 years) who were divided into three groups: young (18–40 years), middle-aged (41–65 years) and elderly (> 65 years), 424 ones completed all follow-ups of 12 weeks. FPG decreased from 178.38 ± 95.04 to 117.90 ± 14.22 mg/dL in the young group, from 180.00 ± 91.08 to 122.94 ± 37.95 mg/dL in the middle-aged group, and from 174.24 ± 80.64 to 128.88 ± 23.4 mg/dL in the elderly group. The proportion of FPG-target-achieved patients increased from 46.2 to 90.4% in the young group, from 32.6 to 82.8% in the middle-aged group, and from 29.5 to 73.3% in the elderly group. The proportion of FPG-target-achieved patients between three age groups were statistically significant (P < 0.001). And the changes of proportion of FPG-target-achieved patients at different follow-up times were statistically significant (P = 0.037). Compared with the young group, the elderly group achieved poorer FPG level (P = 0.032).

Conclusion
MHMS can help patients with T2DM lower FPG and improve proportion of FPG-target-achieved patients. Younger patients may achieve better glycaemic control than older patients. MHMS may serve multitudinous patients with T2DM to achieve adequate FPG self-management.
COVID-19 and the forgone health benefits of elective operations
Authors: Gandjour Afschin 
Published: December 2022

AbstractBackground and aimThe first SARS-CoV-2 pandemic wave in Germany involved a tradeoff between saving the lives of COVID-19 patients by providing sufficient intensive care unit (ICU) capacity and foregoing the health benefits of elective procedures. This study aims to quantify this tradeoff.MethodsThe analysis is conducted at both the individual and population levels. The analysis calculates quality-adjusted life years (QALYs) to facilitate a comparison between the health gains from saving the lives of COVID-19 patients in the ICU and the health losses associated with postponing operative procedures. The QALYs gained from saving the lives of COVID-19 patients are calculated based on both the real-world ICU admissions and deaths averted from flattening the first wave. Scenario analysis was used to account for variation in input factors.ResultsAt the individual level, the resource-adjusted QALY gain of saving one COVID-19 life is predicted to be 3 to 15 times larger than the QALY loss of deferring one operation (the average multiplier is 9). The real-world QALY gain at the population level is estimated to fall within the range of the QALY loss due to delayed procedures. The modeled QALY gain by flattening the first wave is 3 to 31 times larger than the QALY loss due to delayed procedures (the average multiplier is 17).ConclusionDuring the first wave of the pandemic, the resource-adjusted health gain from treating one COVID-19 patient in the ICU was found to be much larger than the health loss from deferring one operation. At the population level, flattening the first wave led to a much larger health gain than the health loss from delaying operative procedures.
miR194 hypomethylation regulates coronary artery disease pathogenesis
Authors: Duan Lian , Liu Yongmei , Li Jun , Zhang Yun , Liao Jiangquan , Dong Yan , Jie Wang 
Published: December 2022

AbstractCoronary artery disease (CAD) is one of the most common heart diseases, characterized by the hardening and narrowing of arteries, resisting blood supply to cardiac muscle. Despite extensive research, the pathogenesis and therapeutic options for CAD remain limited. Epigenetic regulation plays a critical role in CAD progression. Here, we report a unique DNA methylation-miRNA-mRNA regulatory network for CAD, delineated through DNA methylation assays, miRNA and mRNA sequencing, bioinformatics analyses. We also identified key signaling pathways in this network, including the miR194 promoter-miR194-MAPK signaling pathway by pyrosequencing, methylation PCR, qRT-PCR. This pathway could play a role in CAD by apoptosis. Our findings suggested that this signaling pathway may be a potential therapeutic target for CAD. We believe that our study significantly contributes to an improved understanding of the role of specific miRNAs methylation, miRNA, and mRNAs in CAD pathogenesis.
Ultrasound-assessed lung aeration correlates with respiratory system compliance in adults and neonates with acute hypoxemic restrictive respiratory failure: an observational prospective study
Authors: Biasucci Daniele Guerino , Loi Barbara , Centorrino Roberta , Raschetti Roberto , Piastra Marco , Pisapia Luca , Consalvo Ludovica Maria , Caricato Anselmo , Grieco Domenico Luca , Conti Giorgio , Antonelli Massimo , De Luca Daniele 
Published: December 2022

Abstract
Background
Lung ultrasound allows lung aeration to be assessed through dedicated lung ultrasound scores (LUS). Despite LUS have been validated using several techniques, scanty data exist about the relationships between LUS and compliance of the respiratory system (Crs) in restrictive respiratory failure. Aim of this study was to investigate the relationship between LUS and Crs in neonates and adults affected by acute hypoxemic restrictive respiratory failure, as well as the effect of patients’ age on this relationship.

Methods
Observational, cross-sectional, international, patho-physiology, bi-center study recruiting invasively ventilated, adults and neonates with acute respiratory distress syndrome (ARDS), neonatal ARDS (NARDS) or respiratory distress syndrome (RDS) due to primary surfactant deficiency. Subjects without lung disease (NLD) and ventilated for extra-pulmonary conditions were recruited as controls. LUS, Crs and resistances (Rrs) of the respiratory system were measured within 1 h from each other.

Results
Forty adults and fifty-six neonates were recruited. LUS was higher in ARDS, NARDS and RDS and lower in control subjects (overall p < 0.001), while Crs was lower in ARDS, NARDS and RDS and higher in control subjects (overall p < 0.001), without differences between adults and neonates. LUS and Crs were correlated in adults [r = − 0.86 (95% CI − 0.93; − 0.76), p < 0.001] and neonates [r = − 0.76 (95% CI − 0.85; − 0.62), p < 0.001]. Correlations remained significant among subgroups with different causes of respiratory failure; LUS and Rrs were not correlated. Multivariate analyses confirmed the association between LUS and Crs both in adults [B = − 2.8 (95% CI − 4.9; − 0.6), p = 0.012] and neonates [B = − 0.045 (95% CI − 0.07; − 0.02), p = 0.001].

Conclusions
Lung aeration and compliance of the respiratory system are significantly and inversely correlated irrespective of patients’ age. A restrictive respiratory failure has the same ultrasound appearance and mechanical characteristics in adults and neonates.
Effect of exoskeleton-assisted Body Weight-Supported Treadmill Training on gait function for patients with chronic stroke: a scoping review
Authors: Yamamoto Rieko , Sasaki Shun , Kuwahara Wataru , Kawakami Michiyuki , Kaneko Fuminari 
Published: December 2022

Abstract
Background
Therapeutic exercise for gait function using an exoskeleton-assisted Body Weight Supported Treadmill Training (BWSTT) has been identified as a potential intervention that allows for task-based repetitive training with appropriate kinematics while adjusting the amount of body weight support (BWS). Nonetheless, its effect on gait in patients with stroke in the chronic phase are yet to be clarified. The primary aim of this scoping review was to present the status of effectiveness of exoskeleton-assisted BWSTT in patients with chronic stroke. The secondary aims were to summarise intervention protocols, types and functions of BWSTT exoskeletal robotic devices currently used clinically.

Method and results
Articles were accessed and collected from PubMed, Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Web of Science databases, which were completed in October 2020. Articles were included if the subjects were adults with stroke in the chronic phase (onset ≥ 6 months) and if they utilised a robotic exoskeleton with treadmill and body weight support and investigated the efficacy of gait exercise. A total of 721 studies were identified, of which 11 randomised controlled trials were selected. All included studies were published from 2008 to 2020. Overall, 309 subjects were enrolled; of these, 241 (156 males, 85 females) participated. Walking outcome measures were used more often to evaluate the functional aspects of gait than to evaluate gait independence. In 10 of 11 studies, showed the effectiveness of exoskeleton robot-assisted BWSTT in terms of outcomes contributing to improved gait function. Two studies reported that exoskeleton-assisted BWSTT with combination therapy was significantly more effective in improving than exoskeleton-assisted BWSTT alone. However, no significant difference was identified between the groups; compared with therapist-assisted BWSTT groups, exoskeleton-assisted BWSTT groups did not exhibit significant change.

Conclusion
This review suggests that exoskeleton-assisted BWSTT for patients with chronic stroke may be effective in improving walking function. However, the potential may be “to assist” and not because of using the robot. Further studies are required to verify its efficacy and strengthen evidence on intervention protocols.
Patterns associated with hunting with dogs in a semiarid region of northeastern Brazil
Authors: Santos Sebastiana Lima , De la Fuente María Fernanda , Alves Rômulo Romeu Nóbrega 
Published: December 2022

Abstract
Background
Hunting has been an important cultural and subsistence activity for the survival of the human population. In the Brazilian semiarid region (Caatinga), the extreme seasonal changes and socioeconomic conditions have made local people dependent on the natural resources available, including wildlife. Although hunting with dogs can result in higher efficiency for hunters, it can also have implications for game species conservation.

Methods
Using an ethnozoological approach (semi-structured questionnaires, free interviews, informal conversations, and free listing technique), this study aimed to analyze the patterns of hunting with dogs activities in a semiarid region of northeastern Brazil by characterizing hunters’ and hunting dogs’ profiles, investigating target and nontarget prey species, hunters’ practices, motivations, and perceptions regarding the efficiency of hunting with dogs.

Results
We found that hunters that use dog assistance were mostly men, of different ages, with an occupation in agriculture, receiving less than a minimum wage, and with a low level of formal education. Hunters use two or more mixed-breed dogs with no clear preference regarding dogs’ sex. The motivations for hunting with dogs included mainly food, sport, and trade. Hunters cited twenty species captured by dogs without distinction between prey’s sex and age (14 mammals, 4 birds, and 2 reptiles). Only six of these were mentioned as being target prey when hunting with dogs. From nontarget species, eight carnivores are usually left at the site of kill, as they have no use to the hunters. Hunters perceived that hunting with dogs could be three times more efficient than hunting without dogs.

Conclusion
Overall, hunting with dogs represents a complex set of local variables, including characteristics of dogs and prey species, hunters’ motivations, and practices that should be considered according to each particular situation. Considering the human dependence on natural resources in the semiarid region, hunters should be included in wildlife management debates to mitigate the threat to game species while allowing sustainable hunting practices.
Transcatheter and surgical aortic valve replacement in patients with left ventricular dysfunction
Authors: Jalava Maina P. , Savontaus Mikko , Ahvenvaara Tuomas , Laakso Teemu , Virtanen Marko , Niemelä Matti , Tauriainen Tuomas , Maaranen Pasi , Husso Annastiina , Kinnunen Eve , Dahlbacka Sebastian , Jaakkola Jussi , Rosato Stefano , D’Errigo Paola , Laine Mika , Mäkikallio Timo , Raivio Peter , Eskola Markku , Valtola Antti , Juvonen Tatu , Biancari Fausto , Airaksinen Juhani , Anttila Vesa 
Published: December 2022

Abstract
Background
Patients with severe aortic stenosis and left ventricular systolic dysfunction have a poor prognosis, and this may result in inferior survival also after aortic valve replacement. The outcomes of transcatheter and surgical aortic valve replacement were investigated in this comparative analysis.

Methods
The retrospective nationwide FinnValve registry included data on patients who underwent transcatheter or surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis. Propensity score matching was performed to adjust the outcomes for baseline covariates of patients with reduced (≤ 50%) left ventricular ejection fraction.

Results
Within the unselected, consecutive 6463 patients included in the registry, the prevalence of reduced ejection fraction was 20.8% (876 patients) in the surgical cohort and 27.7% (452 patients) in the transcatheter cohort. Reduced left ventricular ejection fraction was associated with decreased survival (adjusted hazards ratio 1.215, 95%CI 1.067–1.385) after a mean follow-up of 3.6 years. Among 255 propensity score matched pairs, 30-day mortality was 3.1% after transcatheter and 7.8% after surgical intervention (p = 0.038). One-year and 4-year survival were 87.5% and 65.9% after transcatheter intervention and 83.9% and 69.6% after surgical intervention (restricted mean survival time ratio, 1.002, 95%CI 0.929–1.080, p = 0.964), respectively.

Conclusions
Reduced left ventricular ejection fraction was associated with increased morbidity and mortality after surgical and transcatheter aortic valve replacement. Thirty-day mortality was higher after surgery, but intermediate-term survival was comparable to transcatheter intervention.
Trial registration The FinnValve registry ClinicalTrials.gov Identifier: NCT03385915.