bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of Substandard and Falsified Antibiotics Sold in the Democratic Republic of the Congo Using Validated HPLC and UV-Visible Spectrophotometric Methods
Authors: Tshilumba Pierrot Mwamba , Ilangala Ange B. , Mbinze Kindenge Jeremie , Kasongo Isaac Mutshitshi , Kikunda Guelord , Rongorongo Elie , Impele Alex Bokanya , Marini Djang’eing’a Roland , Ndoumba Jean-Baptiste Kalonji 
Published: June 2023

ABSTRACT.
The access to afford safe, effective, and genuine medications is a major challenge for people in low- to middle-income countries. This study aimed at developing and validating simple, accurate, and inexpensive analytical liquid chromatography and ultraviolet-visible spectrophotometric methods to ensure quality control of antibiotics sold in formal and informal pharmaceutical markets. It focused on four antibiotics (azithromycin [AZT], cefadroxil [CFD], cefixime [CFX], and erythromycin [ERH]) used to treat infectious diseases in the region of Haut-Katanga in the Democratic Republic of the Congo (DRC). The total error strategy (accuracy profile) matching with the validation requirements of International Council on Harmonization was used for the validation. The validation results showed that three analytical methods of AZT, CFD, and ERH were validated according to the accuracy profile obtained, whereas the proposed method of CFX was not validated. Therefore, the United State Pharmacopoeia method permitted to quantify CFX samples. The dosage intervals ranged from 25 to 75 µg/mL for CFD, from 750 to 1,500 µg/mL for AZT, and from 500 to 750 µg/mL for ERH. The application of the validated method to samples collected (N = 95) allowed the detection of 25% substandard antibiotics with a rate of poor quality much higher in the informal circuit compared with the formal one (54% versus 11%; P < 0.05). The routine application of these methods will strengthen the quality control of drugs marketed in DRC. This study gives evidence for the availability of poor-quality antibiotics in the country, requiring the immediate attention of the national medicine regulatory authority.
La promesa. Notas para una elaboración teológica del deseo humano
Authors: Serrano Vega Carmen 
Published: June 2023

¿Es posible proponer una teología que ignore el dinamis­mo del deseo humano? Lo que en otros tiempos pudo ser objeto de sos­pecha se presenta en este occidente hastiado de promesas incumplidas como oportunidad para recordar al hombre la respuesta a la pregunta que él mismo es. El deseo remite a Dios, como veremos, pero el mismo Dios educa ese deseo humano desde la pedagogía de la promesa. Unapedagogía a la que no fue ajeno Jesús, que se ejemplifica en la vida deMaría y de la Iglesia, que la Iglesia actualiza en los sacramentos y quemodela la esperanza final.
Ministros ordenados al servicio de la comunidad. Los primeros siglos en la reflexión de los Santos Padres
Authors: Leal Lobón Manuel 
Published: June 2023

Acercándonos a los Santos Padres y dejándonos llevar por ellos queremos en estas páginas reflexionar sobre el ministerio eclesiástico, atendiendo de manera sencilla al pensamiento y a las palabras de los Padres en tanto que recogen el pensar y sobre todo el sentir de las comunidades cristianas de su tiempo. En estas primeras iglesias el ministerio se comprende desde el servicio como entrega confiada y generosa al Padre, y entienden que en Cristo y sólo en Él este servicio alcanza su plenitud.
Detection of Reactive Oxygen Species during Photodynamic Therapy
Authors: Pal Dipakshi 
Published: June 2023

Reactive oxygen species (ROS), also known as oxidants, are often utilized in a variety of therapies, such as in photodynamic therapy (PDT) which is an emergent cancer and tumor therapy. The production of ROS in cancerous cells induces oxidative stress, promoting apoptotic cell death. Here we utilize fluorescent molecular sensors to quantify the generation of ROS by a photosensitizer and a room-temperature plasma source. We observe a linear increase in the production of ROS in solution, as a function of light irradiation dose, as measured by the intensity of fluorescence of sensor molecules. The same trend was also observed using the plasma source. It was also observed that in both experiments the signal saturated after prolonged irradiation time. This can be attributed to finite concentration of sensor molecules present in the solution. While ROS production can continue to increase linearly due to further irradiation, the increase in ROS can no longer be detected after prolonged irradiation time due to the limited number of sensors in the sample.
Merging Participatory Action Research and System Dynamics as a Locus for Transformation in a Large Scale Hospital Setting
Authors: Ansermeah MMF 
Published: June 2023

In this paper, we report on the utility of merging Participatory Action Research (PAR) with System Dynamics (SD) as a locus for stimulating transformation in a large-scale hospital academic setting. This is significant because it provides points of cross fertilisation whereby the two frameworks act synergistically with each other to create high leverage interventions for change, which may otherwise not have been apparent. Coupled within a SD auspice, there was a synergistic blend of uncovering an overall ecological view of the public health care system. The PAR methodology is located within the epistemological realm of critical theory and constructivism, whereby facilitating positive social change is viewed to be the key outcome of such research. This outcome has been confirmed by the researchers prioritizing the necessity for a departure from the traditional expert-led health system, evolving into one which supports the empowerment of patients and health-care workers as a necessity. However, the implementation of the improvements has not been as straightforward as initially projected. Some of the challenges included the slow assimilation of proposed solutions for planned care and paucity of key engagement from upstream stakeholders. The value of this paper can potentially serve to encourage key stakeholders in public health care systems to consider viewing health care complexity through the lens of PAR and SD.
Appropriation of Adult Education for Academic Achievement Towards Sustaining the Rights of Physically Challenged Students in Higher Institutions in Lagos
Authors: Ajayi Rachael Adejoke , Aranmolate Temitope Raheedat 
Published: June 2023

Purpose: The study examined the appropriation of adult education for academic achievement towards sustaining the rights of physical challenged students in higher institutions in Lagos.
Methodology: The research design employed in the study was a descriptive survey. The population consisted of all higher institutions located in Lagos State. To gather data, a simple random sampling technique was utilized to choose ten (10) higher institutions from which fifteen (15) physically challenged students were selected from each institution. This amounted to a sample size of one hundred and fifty (150) respondents for the study. The data collection process utilized a self-developed questionnaire as the primary instrument. It was developed in 2 Likert scale of Agreed and Disagreed. The instrument was moderated by experts who affirmed its validity. The reliability of the instrument was assessed through the utilization of the Pearson Product Moment Correlation Coefficient (PPMC). The data collected were then analyzed using statistical tools such as simple percentage and standard deviation.
Findings: The study's findings indicated that adult literacy significantly contributes to adult sustainable development, fostering economic, social, and environmental sustainability. Furthermore, it establishes conducive circumstances for empowering active global citizens. By effectively employing adult education, individuals with physical challenges can acquire a comprehensive comprehension of various concepts and lead their lives in a proficient manner.
Unique Contributions to Theory, Policy and Practice: Adult education has a wide-ranging positive influence on various aspects relevant to adults. Importantly, these advantages extend beyond the professional sphere and encompass different aspects of daily life for individuals with physical challenges. These benefits extend beyond the professional realm and extend to various facets of everyday life for physically challenged individuals. As a result, it is recommended that to guarantee the sustainability of the human rights of physically challenged students, the government should assume the primary responsibility of providing trained and qualified teachers/facilitators, along with other supportive staff, who will cater to the educational needs of these special students.
Entrepreneurial Elements of Activity for Value-Based Selling -A Product Centric Perspective Model
Authors: Tolymat Ahmed Raafat , Abdelaziz Rasha , Salam Mohamed Abdel , Shawky Ayman 
Published: June 2023

Purpose: The successful implementation of VBS entails eight process elements of activity Yet Practical application showed a difference between theory and practice when its about to turning the concept into action in entrepreneurial domain, to address this gap this study aims to contribut to the improvement of the VBS implementation processes by exploring and designing a Product Centric VBS model for entrepreneurs, and by doing this to contribute to the general body of knowledge of VBS.
Methodology: The research design builds on the Descriptive practice-oriented research methodology.
Findings: While our study confirms earlier research on value-based selling antecedes and consequences we also identify epistemological assumption that the marketing organizational tier is the appropriate level for initiating VBS elements of activity hence the value co-creation process will be rationally superseded by value pre-crafting in collaboration between supplier and transitional entrepreneur.
Unique Contributions to Theory, Policy and Practice: As earlier studies for Successful implementation of value-based selling and the conceptualization of the approach adopted a customer value co-creation perspective. These descriptions can form first stone in the milestone for further research in which propositions could be tested based on the assumptions that we used when we elaborated the parameters that form the construct of the model that we developed.
Madonna’s Erotica
Authors: Dango Michael 
Published: June 2023

Everyone wanted Madonna’s Erotica to be scandalous, even pornographic. In the midst of the early 1990s culture wars, conservatives wanted it to be proof of the decline of family values. The target of conservative loathing, gay men reeling from the AIDS epidemic wanted it to be a celebration of a sexual culture that had rapidly slipped away. And of course Madonna herself, who released the album at the same time as her actually pornographic coffee-book table simply titled Sex, knew sex sells.
But Erotica is more sentimental than sexual. At a time when sex was deadly, this sentimentality was not kitsch, but a way of sustaining a sexual culture. In this book, Michael Dango shows how Erotica marks an inflection point in multiple narratives. It is the album in which Madonna began more directly addressing her gay audience, at the same time that gay politics was transitioning from a sexual liberation framework to a rights-based framework that would ultimately culminate in same-sex marriage. To tell this story, Dango draws on his own experiences positioned between two generations of gay people—between a generation decimated by AIDS and a generation that grew up assuming they would be able to get married—as well as works of queer theory, which emerged in the academy at the same time as Madonna emerged on the music scene.
TINGKAT PENGETAHUAN DAN SIKAP MAHASISWA FARMASI DAN NON FARMASI TERHADAP PENGGUNAAN TABIR SURYA
Authors: Hesti Hesti , Adhayanti Ida , Abdullah Tajuddin 
Published: June 2023

Indonesia merupakan negara tropis yang dianugerahi dengan limpahan sinar matahari yang menyebabkan pentingnya proteksi terhadap kulit. Salah satunya dengan pemakaian tabir surya. Pengaplikasian tabir surya yang benar sangat memengaruhi tingkat efektifitasnya dalam memberikan perlindungan. Pengetahuan merupakan salah satu faktor yang menunjang dalam penggunaan tabir surya. Salah satu bidang yang dipelajari mahasiswa farmasi adalah kosmetik. Penelitian ini dilakukan untuk mengetahui perbandingan tingkat pengetahuan dan sikap mahasiswa farmasi dan non farmasi terhadap penggunaan tabir surya. Penelitian ini merupakan penelitian deskriptif yang menggunakan desain cross sectional. Pengambilan sampel pada penelitian ini menggunakan tabel Isaac dan Michael. Teknik pengambilan data menggunakan kuisioner yang diisi secara online yang terdiri dari 14 pertanyaan tentang pengetahuan dan 21 pertanyaan tentang sikap. Hasil penelitian menunjukkan mahasiswa farmasi dan non farmasi memiliki tingkat pengetahuan yang buruk dengan masing-masing skor 17 dan 16. Sedangkan tingkat sikap dari kedua jurusan ini adalah baik dengan masing-masing skor 39 dan 38. Setelah dilakukan uji Mann Whitney, ditemkuan adanya perbedaan yang bermakna pada tingkat pengetahuan antara mahasiswa farmasi dan non farmasi (P=0,000). Namun, pada tingkat sikap tidak ditemukan perbedaan yang signifikan (P=0,578). Hasil tersebut menunjukkan mahasiswa farmasi memiliki tingkat pengetahuan yang lebih baik daripada mahasiswa non farmasi, walaupun masih dalam kategori yang sama yaitu buruk. Sehingga edukasi terkait tabir surya perlu dilakukan untuk memperbaiki kondisi ini.
Eksistensi Profesi Pekerjaan Sosial Melalui Media Sosial Indonesia
Authors: Abdullah Hasyim 
Published: June 2023

Arus teknologi informasi semakin berkembangan pesat, sehingga perlu dimanfaatkan dalam berbagai hal salah satunya dengan mempromosikan dan mensosialisasikan berbagai hal termasuk didalamnya eksistensi pekerjaan sosial, profesi pekerjaan sosial menjadi salah satu di Indonesia yang butuh pengenalan lebih dalam bagi masyarakat Indonesia, dengan masih banyaknya pengertian tentang profesi ini yang kurang dimengerti orang banyakn sehingga didalam artikel ini penulis akan memberikan gambaran mengenai Eksistensi Pekerjaan seperti apa pada Era Milenial ini dan melihatnya dalam berbagai media Online yang ada. Dengan metode yang digunakan adalah kualitatif Deskriptif.penulis melihat berbagai tanggapan dan komentar dalam berbagai postingan yang dilakukan oleh beberapa organisasi profesi pekerjaan sosial di Indonesia dan mengkrucutkn kedalam sebuah teori. Dan teori yang digunakan dalam penelitiaan ini adalah Teori Eksistensi Bourdeu yang menjelaskan eksistensi kedalam 3 hal Belongging, Legitimacy, Recognition. Temuan dalam penelitian ini dari Teori Eksistensi Bourdeu profesi pekerjaan sosial baru sebatas menerapkan 2 konsep saja yang pertama adalah cara berkomunikasi (Belongging), dimana para pekerja sosial melakukan berbagai pengenalan melalui media online tentang hal-hal mendasar dalam profesi Pekerjaan Sosial ini. kedua ialah Legitimation atau peraturan hal ini juga sudah terpenuhi dengan adanya Undang-Undang Nomor 14 Tahun 2019 tentang Profesi Pekerjaan Sosial Di Indonesia. Dan yang ketiga ini masih belum terlaksana dan diterapkan Recognition adanya pengakuan keadaan diterima atau dihargainya dari sesuatu yang dicoba diperkenalkan ialah Profesi Pekerjaan Sosial.
Peningkatan Prestasi Belajar Siswa dengan Menerapkan Model Pembelajaran Discovery Learning pada Pembelajaran IPS Materi Pasar Bebas di Kelas IX-5 Semester 2 SMPN 4 Bolo Tahun Pelajaran 2022/2023
Authors: Kartini Kartini 
Published: June 2023

Tujuan penelitian tindakan kelas ini yaitu mendeskripsikan cara meningkatkan prestasi belajar siswa dan dampaknya melalui model pembelajaran discovery learning di kelas IX-5 SMPN 4 Bolo pada pembelajaran IPS materi pasar bebas semester 2 tahun pelajaran 2022/2023. Subyek perbaikan adalah siswa-siswi kelas IX-5 SMPN 4 Bolo dengan jumlah siswa 31 terdiri dari 15 orang laki-laki dan 16 orang perempuan. Hasil refleksi pada prasiklus menunjukan bahwa prestasi belajar siswa rendah. Hal ini ditunjukkan dengan rendahnya rata-rata nilai formatif tes siswa yakni 73,74, dengan ketuntasan klasikal 64,52%. Nilai rata-rata dan ketuntasan klasikal ini jauh dari indikator keberhasilan yang diinginkan, yaitu nilai rata-rata ≥75.00 dengan ketuntasan klasikal ≥85.00%. Penelitian dilakukan dan hasil yang didapatkan pada posttes siklus 1 adalah nilai rata-rata 74,65, dengan porsentase ketuntasan 74,19%. Nilai rata-rata dan persentase ini masih dibawah indikator keberhasilan yang ditentukan, sehingga dari sisi prestasi belajar siklus 1 belum berhasil. Pada kinerja guru, skor kinerja dalam perencanaan dan pelaksanaan kegiatan pembelajaran pada siklus 1 berada pada angka 4,35 . Dengan demikian dari sisi kinerja guru siklus 1 juga belum mencapai indikator kinerja yang ditetapkan yakni ≥4,55. Pada siklus 2, hasil posttes menunjukkan rata-rata 77,48 dan persentase ketuntasan klasikal pada angka 90,32%. Nilai rata-rata dan persentase ini mencapai indikator keberhasilan yang telah ditetapkan, sehingga dari sisi prestasi belajar siklus 2 telah berhasil. Sementara itu, skor kinerja guru dalam merencanakan dan melaksanakan kegiatan pembelajaran pada siklus 2 yaitu 4,60 dan mencapai indikator kinerja yang diinginkan yakni ≥4,55. Peningkatkan prestasi belajar siswa, disebabkan oleh peningkatan aktivitas, interaksi guru dan siswa dalam proses pembelajaran di kelas dengan menerapkan metode discovery learning yang dilaksanakan guru, sesuai dengan nilai kinerja guru. Dengan tercapainya indikator keberhasilan yang ditetapkan, maka pelaksanaan perbaikan pembelajaran hanya sampai siklus 2 saja.
eleição municipal de 2012 em São Paulo:
Authors: Guilherme Cassio Augusto 
Published: June 2023

Este artigo narra e discute a eleição municipal de 2012 em São Paulo. A hipótese de trabalho é que os temas: voto evangélico, antipetismo e o uso de fake news foram constantes e importantes para a disputa. Elementos estes que seriam posteriormente exacerbados nas eleições nacionais seguintes. Para tanto, usa-se como fonte e objeto de análise o jornal O Estado de S. Paulo, em debate com parte da bibliografia existente. O objetivo é contribuir para os debates da história política do tempo presente no Brasil.
Espetáculo No Singular (2012) em perspectiva:
Authors: Mazza Samuel Nogueira 
Published: June 2023

o espetáculo No Singular (2012) é uma obra coreográfica da Quasar Cia. de Dança, companhia que surge em Goiânia, no ano de 1988, com a união do coreógrafo Henrique Rodovalho e da dançarina Vera Bicalho, que ficou responsável pela direção geral da Quasar, sendo ambos dissidentes da Academia Energia de Julson Henrique, tido como um dos inauguradores da “dança contemporânea” no estado. Por outro lado, o espetáculo de 2012 surge em um contexto específico em que a companhia já desfrutava de certo prestígio nacional e internacional. Essa pesquisa, especificamente, insere-se no campo da História Cultural que teve um desenvolvimento significativo a partir da, comumente chamada, terceira geração da Escola dos Annales. E é nesse campo de análise que iremos desenvolver nossas preocupações em torno da Quasar e de No Singular.
Histórias, memórias e trabalho em equipe:
Authors: Mattioni José Victor Dornelles 
Published: June 2023

O ano de 2022 tornou-se um marco histórico na educação do estado de Roraima pois representou o retorno efetivo do ensino presencial nas escolas da rede pública. Após 2 anos de atividades remotas, professores da Escola Estadual Oswaldo Cruz buscam elaborar projetos de incentivo ao trabalho em equipe e empatia conciliando com o(s) seu(s) respectivos componentes curriculares, como uma estratégia de acolhimento para os alunos. Uma das estratégias escolhidas são as atividades de campo pelo centro histórico de Boa Vista. E isto ocorreu por meio de parcerias com outras instituições. Neste mesmo ano, à convite do Tribunal de Justiça do Estado de Roraima (TJRR), ocorreu uma atividade inédita para os alunos de visitação ao Fórum Advogado Sobral Pinto, Palácio da Justiça e Centro Histórico da cidade de Boa Vista, com o objetivo de incentivar a transdisciplinaridade, a educação histórica e patrimonial (DCRR, 2022), apresentar a história do Poder Judiciário de Roraima e divulgar o seu Centro de Memória e Cultura, relacionando-as com a vivência e empatia dos alunos no tempo presente (BNCC, 2017). Como resultado, os alunos demonstraram que estas atividades estimulam a gostar mais do componente curricular de História, assim como a sua permanência e estímulo para continuar na escola.
La vigilanza sull’amministrazione economica della Curia Romana
Authors: Cavana Paolo 
Published: June 2023

The Supervision of the economic administration of the Roman Curia
ABSTRACT: This paper analyses the new system of supervision of the economic administration of the Roman Curia introduced by the Apostolic Constitution Praedicate Evangelium. Then, it focuses on the role that has been recently assigned in this area to the ‘Istituto per le Opere di Religione’ (IOR) and on that of the Vatican penal jurisdiction, both of which constitute highly innovative elements.
SOMMARIO: 1. Le fonti normative della riforma - 2. Gli organismi di vigilanza - 3. Le plurime tipologie di vigilanza - 4. Analisi del nuovo sistema di vigilanza sull’amministrazione economica della Curia Romana - 5. Il ruolo peculiare dell’Istituto per le Opere di Religione - 6. La duplicazione del sistema di vigilanza tra Curia Romana e IOR - 7. Aspetti positivi del sistema e sue criticità - 8. Vigilanza canonica e supplenza della giurisdizione penale vaticana - 9. Osservazioni conclusive.
O desinteresse dos estudantes pelas aulas de educação física
Authors: Weber Talia Vitória , De Oliveira Carolina Machado , Nasário Júlio César , Rossini Ivana Schmidt , Reinicke Sarita Martins Caminã , Araldi Franciane Maria , Trusz Renato Daniel , Farias Gelcemar Oliveira 
Published: June 2023

Os benefícios da prática de exercício físico são conhecidos e relatados por inúmeros especialistas e estudiosos acerca do tema e cada vez mais eles vêm sendo evidenciados pelos meios de comunicação, mídias sociais e profissionais da área. Mesmo sabendo de sua importância, por que tantos jovens optam por não praticar as atividades propostas pelos professores de Educação Física? Estaria a disciplina sendo vista como atividade extracurricular e sem importância para alguns alunos? O objetivo do presente estudo é identificar fatores responsáveis pelo afastamento dos alunos das aulas de Educação Física. Entende-se este tema de uma extrema importância para aqueles que têm interesse em promover uma educação significativa para seus alunos, pois a Educação Física pode propiciar diversos benefícios, melhorando a saúde de forma geral. Deste modo, identifica-se a necessidade de se observar o fazer pedagógico do docente, que deve apresentar novos conhecimentos na prática de atividades físicas, oportunizando vivências que de fato serão praticadas, incluindo aqueles que um dia se sentiram excluídos. Percebe-se que ainda ocorre discriminação relacionada à Educação Física escolar, que é vista como algo banal e sem importância para a própria escola. Tendo em vista que nem todo desinteresse é por parte do aluno, existe uma parcela de responsabilidade do próprio professor de Educação Física, pois compreende-se que o mesmo tem extenso repertório educativo e deveria utilizá-lo para desenvolver competências e habilidades, além de incentivar e conscientizar a autonomia nas práticas de atividades físicas, não restringindo o ensino a somente algumas modalidades esportivas, privilegiando somente os mais aptos fisicamente.