bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing a PROACTive Care Pathway to Empower and Support Survivors of Breast Cancer
Authors: Franzoi Maria Alice , Degousée Lena , Martin Elise , Semedo Patricia Miguel , Aupomerol Marion , Soldato Davide , Di Meglio Antonio , Chiodi Camila , Barbier Aude , Chaouachi Hajer , Renvoisé Nathalie , Boinon Diane , Fasse Léonor , Ribeiro Joana , Le-Provost Jean Bernard , Arvis Johanna , Lazorthes Céline , di Palma Mario , de Jesus Anne , Raynard Bruno , Pagès Arnaud , Delaloge Suzette , Pistilli Barbara , Scotté Florian , Vaz-Luis Ines 
Published: June 2023

PURPOSE Optimal comprehensive survivorship care is insufficiently delivered. To increase patient empowerment and maximize the uptake of multidisciplinary supportive care strategies to serve all survivorship needs, we implemented a proactive survivorship care pathway for patients with early breast cancer at the end of primary treatment phase. METHODS Pathway components included (1) a personalized survivorship care plan (SCP), (2) face-to-face survivorship education seminars and personalized consultation for supportive care referrals (Transition Day), (3) a mobile app delivering personalized education and self-management advice, and (4) decision aids for physicians focused on supportive care needs. A mixed-methods process evaluation was performed according to the Reach, Effectiveness, Adoption, Implementation and Maintenance framework including administrative data review, pathway experience survey (patient, physician, and organization), and focus group. The primary objective was patient-perceived satisfaction with the pathway (predefined progression criteria for pathway continuation ≥70%). RESULTS Over 6 months, 321 patients were eligible for the pathway and received a SCP and 98 (30%) attended the Transition Day. Among 126 patients surveyed, 77 (66.1%) responded. 70.1% received the SCP, 51.9% attended the Transition Day, and 59.7% accessed the mobile app. 96.1% of patients were very or completely satisfied with the overall pathway, whereas perceived usefulness was 64.8% for the SCP, 90% for the Transition Day, and 65.2% for the mobile app. Pathway implementation seemed to be positively experienced by physicians and the organization. CONCLUSION Patients were satisfied with a proactive survivorship care pathway, and the majority reported that its components were useful in supporting their needs. This study can inform the implementation of survivorship care pathways in other centers.
Quantum recoherence in the early universe
Authors: Colas Thomas , Grain Julien , Vennin Vincent 
Published: June 2023

Abstract
Despite being created through a fundamentally quantum-mechanical process, cosmological structures have not yet revealed any sign of genuine quantum correlations. Among the obstructions to the direct detection of quantum signatures in cosmology, environmental-induced decoherence is arguably one of the most inevitable. Yet, we discover a mechanism of quantum recoherence for the adiabatic perturbations when they couple to an entropic sector. After a transient phase of decoherence, a turning point is reached, recoherence proceeds and adiabatic perturbations exhibit a large amount of self-coherence at late-time. This result is also understood by means of a non-Markovian master equation, which reduces to Wilsonian effective-field theory in the unitary limit. This allows us to critically assess the validity of open-quantum-system methods in cosmology and to highlight that re(de)coherence from linear interactions has no flat-space analogue.
Justifying Sex in Arcadia
Authors: Scozzaro Connie 
Published: June 2023

AbstractPhilip Sidney’s Old Arcadia features two knights who commit instances of violent sex, for which they are sentenced to death. Ultimately, they are saved, and this essay asks why—and how—the language of self-abjection is used in the service of justice. Exploring the rhetorics of mercy and masochism, the essay examines the poetic justifications for violent sex that draw on the Petrarchan tradition. Sidney’s prose romance explores the social and narrative implications for living out the conventions of erotic poetry. His suffering lover occludes his violent actions by insisting that love is a mutual injury, and thus he is a victim too. Since it contains conventional apologies for ravishment, and provocations to touch, the blazon may also be considered a precursor to violent sex. Finally, Sidney rescues his knights, unpersuasively, with a marvelous and “strange conceit” that replaces the demands of justice with the demands of romance as a genre.
Ca2+ and cAMP open differentially dilating synaptic fusion pores
Authors: Bulgari Dinara , Cavolo Samantha L. , Schmidt Brigitte F. , Buchan Katherine , Bruchez Marcel P. , Deitcher David L. , Levitan Edwin S. 
Published: June 2023

ABSTRACT
Neuronal dense-core vesicles (DCVs) contain neuropeptides and much larger proteins that affect synaptic growth and plasticity. Rather than using full collapse exocytosis that commonly mediates peptide hormone release by endocrine cells, DCVs at the Drosophila neuromuscular junction release their contents via fusion pores formed by kiss-and-run exocytosis. Here, we used fluorogen-activating protein (FAP) imaging to reveal the permeability range of synaptic DCV fusion pores and then show that this constraint is circumvented by cAMP-induced extra fusions with dilating pores that result in DCV emptying. These Ca2+-independent full fusions require PKA-R2, a PKA phosphorylation site on Complexin and the acute presynaptic function of Rugose, the homolog of mammalian neurobeachin, a PKA-R2 anchor implicated in learning and autism. Therefore, localized Ca2+-independent cAMP signaling opens dilating fusion pores to release large cargoes that cannot pass through the narrower fusion pores that mediate spontaneous and activity-dependent neuropeptide release. These results imply that the fusion pore is a variable filter that differentially sets the composition of proteins released at the synapse by independent exocytosis triggers responsible for routine peptidergic transmission (Ca2+) and synaptic development (cAMP).
Using 15N to determine the metabolic fate of dietary nitrogen in North Pacific spiny dogfish (Squalus acanthias suckleyi)
Authors: Hoogenboom J. Lisa , Anderson W. Gary 
Published: June 2023

ABSTRACT
Marine elasmobranchs are ureosmotic, retaining large concentrations of urea to balance their internal osmotic pressure with that of the external marine environment. The synthesis of urea requires the intake of exogenous nitrogen to maintain whole-body nitrogen balance and satisfy obligatory osmoregulatory and somatic processes. We hypothesized that dietary nitrogen may be directed toward the synthesis of specific nitrogenous molecules in post-fed animals; specifically, we predicted the preferential accumulation and retention of labelled nitrogen would be directed towards the synthesis of urea necessary for osmoregulatory purposes. North Pacific spiny dogfish (Squalus acanthias suckleyi) were fed a single meal of 7 mmol l−1 15NH4Cl in a 2% ration by body mass of herring slurry via gavage. Dietary labelled nitrogen was tracked from ingestion to tissue incorporation and the subsequent synthesis of nitrogenous compounds (urea, glutamine, bulk amino acids, protein) in the intestinal spiral valve, plasma, liver and muscle. Within 20 h post-feeding, we found labelled nitrogen was incorporated into all tissues examined. The highest δ15N values were seen in the anterior region of the spiral valve at 20 h post-feeding, suggesting this region was particularly important in assimilating the dietary labelled nitrogen. In all tissues examined, enrichment of the nitrogenous compounds was sustained throughout the 168 h experimental period, highlighting the ability of these animals to retain and use dietary nitrogen for both osmoregulatory and somatic processes.
The 2020 EFQM Model digital transformation: Νew features and Assessors' view
Authors: Deliou Cleopatra , Koemtzi Maria 
Published: June 2023

Background: The EFQM Model, the most widely applied Business Excellence Model in Europe, can be used by any type of organization in order to conduct a thorough analysis of its strengths and its areas for improvement. The model can be used in two ways: both as a diagnostic tool for self-assessment and as a model for management control.
Purpose: The main objective of this paper is to identify and analyze the modifications introduced to the latest version of the EFQM Model (version 2020). In an attempt to depict the main elements of the revised version, a comparison is made between the last and the previous version of the model aiming to identify the key features that need to be considered by applicant organizations when they decide to fulfill the model’s new requirements.
Methodology: A literature review is conducted in order to illustrate the evolution of the model to date and a comparative analysis is used as a key research method for studying the differences between the last two versions of the model. The research is supported by interviewing Certified Assessors of the EFQM Model who have already got trained in the new features of the latest version.
Findings: The 2020 version allows organizations and individuals to embrace change, drive performance and evolve for the future. The creation of the Assess Base has replaced the previous paper – driven process and it brought the assessment process a step closer to digitalization for both EFQM members and Assessors.
Research Limitation: The latest version of the EFQM Model 2020 is very new and the knowledge related to its use is very limited. Therefore, the findings of this paper are mainly driven by the Assessors’ knowledge and involvement with little possibility to question or confirm the points extracted from them.
Originality/ value: This paper is the first attempt to compare the last two versions of the EFQM Model. By illustrating the new key features introduced to the model, this paper may form the basis for further research on the benefits gained by the use of these features.
EL classification: Μ19
Keywords: EFQM model, 2020 version, comparative data, stakeholders
The modern organizational environment: Communication, Networking and new technologies as driving forces for sustainability, progress & strategic alignment.
Authors: Markaki Evangelia , Chadjipadelis Theodore 
Published: June 2023

The current study presents the driving sources and the challenges of the modern organizational environments. The New forms of communication, networking, the multicultural environment, and the structural issues in organizations as well as ethics are some of the challenges that the modern organizational environment deals with. We ask employees of different demographic background to evaluate all these new changes and challenges and we assess how people react towards these new characteristics. We also investigate how people believe organizations can integrate these new trends in compliance with an effective organizational performance. The use of the Conjoint Analysis and the scenario technique allow us to investigate and understand the significance of different characteristics or factors that influence the modern organizational environment and the coexistence of different generations in organizations. The Conjoint Analysis is a multidimensional analysis that can also provide information in a group but also in an individual level. This can help us to create interesting metrics for people and segmentations that lead to an organizational strategic design and sustainability. The present study can have applications in the business, social science, and politics environment.

EL Classifications: G34, G14, M41.
Key words: Strategic Alignment, Sustainability, Communication, Networking, Conjoint Analysis.
Well-being as a tool to improve productivity in existing office space: Case study in Alexandria, Egypt
Authors: Hamadah Miral , ElSeragy Ahmed , ElDeeb Sally 
Published: June 2023

Background: The green building industry has significantly impacted the construction market, providing various sustainable solutions for the community. However, conventional green building standards have yet to adequately address occupant health and well-being, leading to challenges with performance. This has caused many businesses to take note of the latest report from the Bureau of Labour Statistics, which indicated that productivity in the US has dropped by the sharpest level since the 1940s [1]. Addressing these issues, organisations like International WELL Building Institute (IWBI) developed WELL Building Rating System (WELL), prioritising occupant health and well-being as critical components for improving performance and avoiding potential vulnerabilities brought about by sickness or pandemics. For this reason, this study will explore how to improve employee productivity within office buildings by bettering their overall health and well-being. Methods: The methodology is designed to collect data from traditional office design, new trended successful office designs, and the WELL Building Rating System to understand healthy building design. Additionally, using DesignBuilder computer software simulates natural daylight, ventilation, and thermal heat gain in the case study to compare implementation results to the base case result. Results: Showing thermal comfort, ventilation, and natural daylight significantly influence employees’ productivity. Implementing conducted design features from WELL achieved an average of 20.2%-35.6% decrease in thermal gain throughout the year, a 20% increase in airflow, an average 2.4%-6.5% decrease in Air temperature, enhanced temperature distribution by 7%, and direct sunlight minimum reduction by 9% in Winter and maximum 21.9% in Spring. Conclusion: Our research analysed that new design features in famous office buildings positively impact employee productivity. We particularly examined the features outlined by WELL Building Rating System to identify the most influential factors affecting occupant productivity. The results of this study informed recommendations for enhancing productivity in existing office buildings in Alexandria, Egypt.
Association between circulating inflammatory biomarkers and functional outcome or perihaematomal oedema after ICH: a systematic review & meta-analysis
Authors: Kirby Caoimhe , Barrington Jack , Sondag Lotte , Loan James J.M. , Schreuder Floris H.B.M. , McColl Barry W. , Klijn Catharina J.M. , Al-Shahi Salman Rustam , Samarasekera Neshika 
Published: June 2023

Background: Currently, there are no specific medical treatments for intracerebral haemorrhage (ICH), but the inflammatory response may provide a potential route to treatment. Given the known effects of acute brain injury on peripheral immunity, we hypothesised that inflammatory biomarkers in peripheral blood may be associated with clinical outcome following ICH, as well as perihaematomal oedema (PHO), which is an imaging marker of the neuroinflammatory response. Methods: We searched OVID Medline and EMBASE on 07 April 2021 for studies of humans with ICH measuring an inflammatory biomarker in peripheral blood and PHO or clinical outcome. Risk of bias was assessed using a scale comprising features of the Newcastle-Ottawa Assessment Scale, STROBE-ME and REMARK guidelines. We used random effects meta-analysis to pool standardised mean differences (SMD) if ≥1 study quantified the association between identical biomarkers and measures of PHO or functional outcome. Results: Of 8,615 publications, 16 examined associations between 21 inflammatory biomarkers and PHO (n=1,299 participants), and 93 studies examined associations between ≥1 biomarker and clinical outcome (n=17,702 participants). Overall, 20 studies of nine biomarkers (n=3,199) met criteria for meta-analysis of associations between inflammatory biomarkers and clinical outcome. Death or dependency (modified Rankin Scale (mRS) 3–6) 90 days after ICH was associated with higher levels of C-reactive protein (CRP) (SMD 0.80; 95%CI [0.44, 1.17]; p<0.0001), fibrinogen (SMD 0.32; 95%CI [0.04, 0.61]; p=0.025), white blood cell (WBC) count (SMD 0.27; 95%CI [0.11, 0.44]; p=0.001) and high mobility group box protein 1 (HMGB1) (SMD 1.67; 95%CI [0.05, 3.30]; p=0.04). Conclusions: Higher circulating levels of WBC, CRP, fibrinogen and HMGB1 are associated with poorer outcomes after ICH. This study highlights the clinical importance of the inflammatory response to ICH and identifies additional research needs in determining if these associations are mediated via PHO and are potential therapeutic targets. Registration: PROSPERO (CRD42019132628; 28/05/2019).
LncRNA PCBP1-AS1 induces osteoporosis by sponging miR-126-5p/PAK2 axis
Authors: Li Zhihui 
Published: June 2023

AimsLong non-coding RNAs (lncRNAs) act as crucial regulators in osteoporosis (OP). Nonetheless, the effects and potential molecular mechanism of lncRNA PCBP1 Antisense RNA 1 (PCBP1-AS1) on OP remain largely unclear. The aim of this study was to explore the role of lncRNA PCBP1-AS1 in the pathogenesis of OP.MethodsUsing quantitative real-time polymerase chain reaction (qRT-PCR), osteogenesis-related genes (alkaline phosphatase (ALP), osteocalcin (OCN), osteopontin (OPN), and Runt-related transcription factor 2 (RUNX2)), PCBP1-AS1, microRNA (miR)-126-5p, group I Pak family member p21-activated kinase 2 (PAK2), and their relative expression levels were determined. Western blotting was used to examine the expression of PAK2 protein. Cell Counting Kit-8 (CCK-8) assay was used to measure cell proliferation. To examine the osteogenic differentiation, Alizarin red along with ALP staining was used. RNA immunoprecipitation assay and bioinformatics analysis, as well as a dual-luciferase reporter, were used to study the association between PCBP1-AS1, PAK2, and miR-126-5p.ResultsThe expression of PCBP1-AS1 was pre-eminent in OP tissues and decreased throughout the development of human bone marrow-derived mesenchymal stem cells (hBMSCs) into osteoblasts. PCBP1-AS1 knockdown and overexpression respectively promoted and suppressed hBMSC proliferation and osteogenic differentiation capacity. Mechanistically, PCBP1-AS1 sponged miR-126-5p and consequently targeted PAK2. Inhibiting miR-126-5p significantly counteracted the beneficial effects of PCBP1-AS1 or PAK2 knockdown on hBMSCs’ ability to differentiate into osteoblasts.ConclusionPCBP1-AS1 is responsible for the development of OP and promotes its progression by inducing PAK2 expression via competitively binding to miR-126-5p. PCBP1-AS1 may therefore be a new therapeutic target for OP patients.Cite this article: Bone Joint Res 2023;12(6):375–386.
Application of optical switching technology in a lunar laser ranging system based on a superconducting detector
Authors: Han XiDa , Wu XianLin , Zhao HongChao , Lin XuDong , Li Ming , Wu ZhiGang 
Published: June 2023

The TianQin
laser
ranging station has
successfully obtained the effective echo signals of the all five
corner-cube reflectors on the lunar surface by using a 1064 nm
Nd:YAG laser with 100 Hz repetition frequency and a 2×2 array of superconducting nanowire
single-photon detectors (SNSPDs). The application of the SNSPD in the
lunar laser ranging system (LLRS) has demonstrated its detection
ability, but it loses its superconducting state and cannot work under
strong stray light conditions. In this paper, a high-speed optical
switch experimental device based on 100 Hz is developed to
solve the application problem of the SNSPD in the LLRS, and its main
technical parameters are tested. The results show that the maximum
running distance of the switch is 200 µm; the switching time is
better than 2 ms; and the extinction ratio is better than
57 dB. Moreover, the application of the high-speed optical
switch experimental device in the lunar laser ranging system is
designed, and the effective detection time between two laser pulses
(10 ms) is determined to be 6.1 ms.
Research on the OAM and reduction of RCS of a dynamically tunable terahertz reconfigurable metasurface
Authors: Li Hao , Qi Yunping , Su Mingrui , Wang Xiangxian 
Published: June 2023

A dynamically tunable reconfigurable metasurface in the terahertz (THz) band combined with the phase-change material vanadium dioxide (VO2) is proposed. Through theoretical and simulation study, the dynamic tunable reconfigurable metasurface designed in this paper works in the wide band of 1.09–2.13 THz frequency, and the polarization conversion ratio of the metasurface can reach more than 95%. Further, the relative bandwidth can reach more than 74%, and it still has good performance after the phase transformation of VO2. A metasurface coded with 3 bits and a special phase arrangement can control the electromagnetic wavefront, generate orbital angular momentum, focus vortices, reflect anomalously, and achieve radar cross section reduction. Therefore, the proposed metasurface has potential applications in secure communication, near-field imaging, wireless transmission, etc.
The association between alcohol consumption and the risk of hepatocellular carcinoma according to glycemic status in Korea: A nationwide population-based study
Authors: Cho Eun Ju , Chung Goh Eun , Yoo Jeong-Ju , Cho Yuri , Shin Dong Wook , Kim Yoon Jun , Yoon Jung-Hwan , Han Kyungdo , Yu Su Jong 
Published: June 2023

Background
Alcohol and diabetes are known risk factors for hepatocellular carcinoma (HCC); however, it is unclear whether the association between alcohol consumption and HCC risk differs by fasting serum glucose level and diabetes. We investigated the dose–response relationship between alcohol consumption and the risk of HCC according to glycemic status.

Methods and findings
This population-based observational cohort study included patients who underwent general health checkups in 2009 using the Korean National Health Insurance Service Database. The primary outcome was HCC incidence, and Cox proportional hazard regression analysis was performed to estimate the relationship between alcohol consumption and HCC risk according to glycemic status. A total of 34,321 patients newly diagnosed with HCC were observed in the median follow-up period of 8.3 years. In the multivariable model, we adjusted for age, sex, smoking, regular exercise, income, hypertension, dyslipidemia, and body mass index. Mild-to-moderate alcohol consumption increased the risk of HCC in all glycemic statuses (normoglycemia: hazard ratio [HR], 1.06; 95% confidence interval [CI], 1.02 to 1.10; prediabetes: HR, 1.19; 95% CI, 1.14 to 1.24; and diabetes: HR, 2.02; 95% CI, 1.93 to 2.11) compared to normoglycemic nondrinking. Heavy alcohol consumption also increased the risk of HCC in all glycemic statuses (normoglycemia: HR, 1.39; 95% CI, 1.32 to 1.46; prediabetes: HR, 1.67; 95% CI, 1.58 to 1.77; and diabetes: HR, 3.29; 95% CI, 3.11 to 3.49) compared to normoglycemic nondrinking. Since alcohol consumption information in this study was based on a self-administered questionnaire, there may be a possibility of underestimation. Although we excluded patients with a history of viral hepatitis using diagnosis codes, we could not obtain information on hepatitis B or hepatitis C serum markers.

Conclusions
Both mild-to-moderate and heavy alcohol consumption was associated with an increased risk of HCC in all glycemic statuses. The increased risk of HCC according to alcohol consumption was the highest in the diabetes group, suggesting that more intensive alcohol abstinence is required for patients with diabetes.