bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival benefit and biomarker analysis of pyrotinib or pyrotinib plus capecitabine for patients with HER2-positive metastatic breast cancer: a pooled analysis of two phase I studies
Authors: Guan Xiuwen , Ma Fei , Li Qiao , Chen Shanshan , Lan Bo , Fan Ying , Wang Jiayu , Luo Yang , Cai Ruigang , Zhang Pin , Li Qing , Xu Binghe 
Published: February 2023

Abstract
Background
Pyrotinib, a novel irreversible tyrosine kinase inhibitor (TKI), has demonstrated promising antitumor activity to improve the overall response rate and progression-free survival (PFS) in patients with HER2-positive metastatic breast cancer (MBC). However, the survival data of pyrotinib or pyrotinib plus capecitabine in HER2-positive MBC remains scarce. Thus, we summarized the updated individual patient data from the phase I trials of pyrotinib or pyrotinib plus capecitabine, to provide a cumulative assessment on long-term outcomes and associated biomarker analysis of irreversible TKIs in HER2-positive MBC patients.

Methods
We performed a pooled analysis of the phase I trials for pyrotinib or pyrotinib plus capecitabine based on the updated survival data from individual patients. Next-generation sequencing was performed on circulating tumor DNA for predictive biomarkers.

Results
A total of 66 patients were enrolled, including 38 patients from the phase Ib trial for pyrotinib and 28 patients from the phase Ic trial for pyrotinib plus capecitabine. The median follow-up duration was 84.2 months (95% CI: 74.7–93.7 months). The estimated median PFS in the entire cohort was 9.2 months (95% CI: 5.4–12.9 months) and median OS was 31.0 months (95% CI: 16.5–45.5 months). The median PFS was 8.2 months in the pyrotinib monotherapy cohort and 22.1 months in the pyrotinib plus capecitabine group, while the median OS was 27.1 months in the pyrotinib monotherapy group and 37.4 months in the pyrotinib plus capecitabine group. Biomarker analysis suggested that the patients harbored concomitant mutations from multiple pathways in HER2-related signaling network (HER2 bypass signaling pathways, PI3K/Akt/mTOR pathway and TP53) were observed with significantly poorer PFS and OS when compared to those with none or one genetic alteration (median PFS, 7.3 vs. 26.1 months, P = 0.003; median OS, 25.1 vs. 48.0 months, P = 0.013).

Conclusions
The updated survival results based on individual patient data from the phase I trials of pyrotinib-based regimen revealed promising PFS and OS in HER2-positive MBC. Concomitant mutations from multiple pathways in HER2-related signaling network may be a potential efficacy and prognosis biomarker for pyrotinib in HER2-positive MBC.

Trial registration
ClinicalTrials.gov. (NCT01937689, NCT02361112).
Metagenomics and metabarcoding experimental choices and their impact on microbial community characterization in freshwater recirculating aquaculture systems
Authors: Rieder Jessica , Kapopoulou Adamandia , Bank Claudia , Adrian-Kalchhauser Irene 
Published: February 2023

Abstract
Background
Microbial communities in recirculating aquaculture systems (RAS) play a role in system success, nutrient cycling, and water quality. Considering the increasing socio-economic role of fish farming, e.g., regarding food security, an in-depth understanding of aquaculture microbial communities is also relevant from a management perspective, especially regarding the growth, development, and welfare of the farmed animal. However, the current data on the composition of microbial communities within RAS is patchy, which is partly attributable to diverging method choices that render comparative analyses challenging. Therefore, there is a need for accurate, standardized, and user-friendly methods to study microbial communities in aquaculture systems.

Results
We compared sequencing approach performances (3 types of 16S short amplicon sequencing, PacBio long-read amplicon sequencing, and amplification-free shotgun metagenomics) in the characterization of microbial communities in two commercial RAS fish farms. Results showed that 16S primer choice and amplicon length affect some values (e.g., diversity measures, number of assigned taxa or distinguishing ASVs) but have no impact on spatio-temporal patterns between sample types, farms and time points. This implies that 16S rRNA approaches are adequate for community studies. The long-read amplicons underperformed regarding the quantitative resolution of spatio-temporal patterns but were suited to identify functional services, e.g., nitrification cycling and the detection of pathogens. Finally, shotgun metagenomics extended the picture to fungi, viruses, and bacteriophages, opening avenues for exploring inter-domain interactions. All sequencing datasets agreed on major prokaryotic players, such as Actinobacteriota, Bacteroidota, Nitrospirota, and Proteobacteria.

Conclusion
The different sequencing approaches yielded overlapping and highly complementary results, with each contributing unique data not obtainable with the other approaches. We conclude that a tiered approach constitutes a strategy for obtaining the maximum amount of information on aquaculture microbial communities and can inform basic research on community evolution dynamics. For specific and/or applied questions, single-method approaches are more practical and cost-effective and could lead to better farm management practices.
Therapeutic plasma exchange in postpartum HELLP syndrome: a case report
Authors: Kojima Nana , Kuroda Kosuke , Tani Makiko , Kanazawa Tomoyuki , Shimizu Kazuyoshi , Maki Jota , Masuyama Hisashi , Morimatsu Hiroshi 
Published: February 2023

Abstract
Background
Postpartum hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is more difficult to treat than HELLP syndrome during pregnancy. We describe a case of postpartum HELLP syndrome that responded to plasma exchange (PE) therapy.

Case presentation
A 30-year-old primipara woman was hospitalized for gestational hypertension at 33 weeks of gestation and underwent an emergent cesarean section at 36 weeks and 6 days of gestation due to rapidly progressing pulmonary edema. After delivery, liver dysfunction and a rapid decrease in platelet count were observed, and the patient was diagnosed with severe HELLP syndrome. She experienced multiple organ failure despite intensive care, and PE therapy was initiated. Her general condition dramatically stabilized within a few hours of PE therapy.

Conclusion
It is controversial whether PE therapy should be used primarily in the management of HELLP syndrome, but early initiation of PE therapy could be effective for severe HELLP syndrome.
The COVID-19 pandemic: knowledge, attitudes and practices of coronavirus (COVID-19) among patients with type 2 diabetes
Authors: Mohamadian Hashem , faraji Amrullah , Ghorrabi Ahmad Tahmasebi , Ghobadi-Dashdebi Kamel , Salahshouri Arash 
Published: February 2023

AbstractBackgroundIt is necessary to evaluate COVID-19 data on Knowledge, Attitudes and Practices (KAP) to confirm effective protective practice and to reduce risk in society. Hence, the study was carried out to determine KAP towards COVID-19 and the factors associated with knowledge and practices among patients with type 2 diabetes (T2D).MethodsIn this cross-sectional (descriptive-analytical) study, 357 patients with diabetes in Izeh participated in the study. The sampling method used was convenience sampling method. Data collection tool was a researcher-made questionnaire of demographic information and KAP of patients with T2D in relation to the new coronavirus. The validity and reliability of the research tool was confirmed using the content validity and test–retest. Data analysis was done in Stata.14.2 and Smartpls 3.2.8 using descriptive and analytical statistical tests.ResultsThe mean score of participants' KAP towards Covid-19 was 74.22 (16.30), 72.88 (14.87), and 70.51 (19.70), respectively. The lowest and the highest score of the patients' knowledge was in the field of transmission (56.60 (20.96)) and care and prevention of the COVID-19 (88.58 (21.88)), respectively. Residence was the most important factor predicting the practice of diabetic patients with an explanatory coefficient ([SMD 1.08 (95% CI 0.85 to 1.30),P < 0.001] and R2 = 0.87%).ConclusionDespite the good level of KAP of people towards the COVID-19 disease, there were answers showing poor knowledge, incorrect beliefs and attitudes, and insufficient practice regarding different aspects of the COVID-19 in some cases in our study. Residence was a strong predictor of type 2 diabetes mellitus (T2DM) patients’ practice in terms of protective behaviors against Covid-19. Hence, educational needs evaluation based on residence is recommended, especially in rural T2DM patients.
Reframing data ethics in research methods education: a pathway to critical data literacy
Authors: Atenas Javiera , Havemann Leo , Timmermann Cristian 
Published: February 2023

AbstractThis paper presents an ethical framework designed to support the development of critical data literacy for research methods courses and data training programmes in higher education. The framework we present draws upon our reviews of literature, course syllabi and existing frameworks on data ethics. For this research we reviewed 250 research methods syllabi from across the disciplines, as well as 80 syllabi from data science programmes to understand how or if data ethics was taught. We also reviewed 12 data ethics frameworks drawn from different sectors. Finally, we reviewed an extensive and diverse body of literature about data practices, research ethics, data ethics and critical data literacy, in order to develop a transversal model that can be adopted across higher education. To promote and support ethical approaches to the collection and use of data, ethics training must go beyond securing informed consent to enable a critical understanding of the techno-centric environment and the intersecting hierarchies of power embedded in technology and data. By fostering ethics as a method, educators can enable research that protects vulnerable groups and empower communities.
Facilitators and barriers to implementing electronic patient-reported outcome and experience measures in a health care setting: a systematic review
Authors: Glenwright Ben G. , Simmich Joshua , Cottrell Michelle , O’Leary Shaun P. , Sullivan Clair , Pole Jason D. , Russell Trevor 
Published: February 2023

Abstract
Objective
This systematic literature review aimed to identify factors that influence the implementation of electronic patient-reported outcome measures (ePROMs) and patient-reported experience measures (ePREMs) in healthcare settings.

Introduction
Improvements in health care through increased patient engagement have gained traction in recent years. Patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) are tools used to improve the quality of care from the patient perspective. The influence of implementing PROMs and PREMs using electronic information systems (ePROMs and ePREMs) is not well understood.

Inclusion criteria
Studies with information related to the implementation of ePROMs and/or ePREMs with a focus on health-related services, irrespective of provider type, were included.

Methods
A literature search of peer-reviewed databases was conducted on the 24th of January 2022 for articles about barriers and facilitators of the implementation of ePROMs/ePREMs in healthcare settings. Two reviewers independently extracted relevant findings from the included studies and performed a descriptive code-based synthesis before collaboratively creating a final consensus set of code categories, which were then mapped to the consolidated framework of implementation research (CFIR). Study quality was appraised using a mixed-methods appraisal tool (MMAT).

Results
24 studies were eligible for inclusion in the screening of 626 nonduplicate studies. Quality assessment using the MMAT revealed that 20/24 studies met at least 60% of the MMAT criteria. Ninety-six code categories were identified and mapped to the constructs across all CFIR domains.

Conclusion
To guide the effective implementation of ePROMs/ePREMs in healthcare settings, factors shown to influence their implementation have been summarised as an implementation checklist for adoption and use by clinicians, organisations, and policymakers.
Patient-reported outcome measures used to improve youth mental health services: a systematic review
Authors: Thapa Bajgain Kalpana , Amarbayan Mungunzul , Wittevrongel Krystle , McCabe Erin , Naqvi Syeda Farwa , Tang Karen , Aghajafari Fariba , Zwicker Jennifer D. , Santana Maria 
Published: February 2023

Abstract
Background
Patient-reported outcome measures (PROMs) are standardized and validated self-administered questionnaires that assess whether healthcare interventions and practices improve patients’ health and quality of life. PROMs are commonly implemented in children and youth mental health services, as they increasingly emphasize patient-centered care. The objective of this study was to identify and describe the PROMs that are currently in use with children and youth living with mental health conditions (MHCs).

Methods
Three databases (MEDLINE, EMBASE, and PsycINFO) were systematically searched that used PROMs with children and youth < 18 years of age living with at least one diagnosed MHC. All methods were noted according to Preferred Reporting Items for Systematic reviews and Meta-Analysis. Four independent reviewers extracted data, which included study characteristics (country, year), setting, the type of MHC under investigation, how the PROMs were used, type of respondent, number of items, domain descriptors, and the psychometric properties.

Results
Of the 5004 articles returned by the electronic search, 34 full-texts were included in this review. This review identified both generic and disease-specific PROMs, and of the 28 measures identified, 13 were generic, two were generic preference-based, and 13 were disease-specific.

Conclusion
This review shows there is a diverse array of PROMs used in children and youth living with MHCs. Integrating PROMs into the routine clinical care of youth living with MHCs could improve the mental health of youth. Further research on how relevant these PROMs are children and youth with mental health conditions will help establish more uniformity in the use of PROMs for this population.
Atypical presentation of polymorphous low-grade neuroepithelial tumor of young (PLNTY): a case report
Authors: Joshi Vijay , Chougule Meghana V. , Mudkanna Anand , Mishra Rakesh Kumar , Maurya Ved Prakash , Agrawal Amit 
Published: February 2023

AbstractThe polymorphous low-grade neuroepithelial tumor of young (PLNTY) is considered as one among the low-grade neuroepithelial tumor; as per WHO-2021 classification of Brain Tumors in the fifth edition. The term PLNTY was first coined by Huse in 2016. These morphologically variable tumors are characterized by their oligodendroglioma-like cellular components, infiltrative growth pattern, and Cluster of Differentiation 34 (CD34) immunopositivity. Frequent genetic abnormalities involving mitogen-activated protein kinase pathway constituents like the BRAF proto-oncogene or fibroblast growth receptor 2/3 are harbored by PLNTYs. Radiologically, these are found to be well-circumscribed lesions with calcified and cystic components, affecting primarily temporal lobes. Clinically, they present with seizures/epilepsy in young adults (< 30 years). In the present manuscript we are reporting a case of 37-year-old male, presenting with a gradually progressive headache for 6 months, found to have a left frontal multiloculated cystic lesion with dystrophic calcifications. Based on the distinctive histopathological feature of the oligodendroglioma-like infiltrative lesion showing CD34 immunopositivity, a diagnosis of a polymorphous low-grade neuroepithelial tumor of young was made.
Can resistance to either isoniazid or rifampicin predict multidrug resistance tuberculosis (MDR-TB)
Authors: Mchaki Betty R. , Mgaya Fauster X. , Kunambi Peter P. , Matee Mecky I. 
Published: February 2023

Abstract
Background
Previous studies have shown significant differences and lack clarity on whether resistance to either isoniazid or rifampicin can predict multidrug resistance tuberculosis (MDR-TB). Some consider rifampicin resistance to be a surrogate for MDR-TB. We, therefore, conducted this study to determine resistance to either isoniazid or rifampicin can predict MDR-TB.

Results
A total of 315 Mycobacteria tuberculosis isolates were tested for resistance against isoniazid, rifampicin, ethambutol and streptomycin using the phenotypic proportion method on Lowenstein–Jensen media. Results showed most isolates (88.9%, 280/315) were not resistant to any anti-TB tested, 5.7% (18/315) were resistant to both isoniazid and rifampicin, 2.5% (8/315) were resistant to rifampicin only and 1.3% (4/315) were resistant to all four first-line anti-tuberculosis. Prediction of MDR TB basing on rifampicin results showed sensitivity of 100.0%, specificity of 96.3%, diagnostic accuracy of 96.5%, and positive and negative predictive values of 62.1% and 100.0%, respectively. Isoniazid had sensitivity of 100.0%, specificity of 98.3%, diagnostic accuracy of 98.4%, and positive and negative predictive values of 78.3% and 100.0%, respectively. Prediction of rifampicin resistance based on isoniazid results had sensitivity of 62.1%, specificity of 98.3%, diagnostic accuracy of 94.9%, a positive predictive value of 78.3% and a negative predictive value of 96.2%.

Conclusions
Resistance to either rifampicin or isoniazid sub-optimally predicts MDR-TB. Despite having high sensitivity and specificity, the positive predictive value of rifampicin was only 62.1% and for isoniazid was 78.3%, suggesting that if either is tested in isolation both could result in false positives MDR-TB cases, resulting into patients being unnecessarily subjected to the more toxic and expensive second-line anti-TB drugs, which are less effective compared to first-line anti-TB drugs.
GNSS techniques for real-time monitoring of landslides: a review
Authors: Huang Guanwen , Du Shi , Wang Duo 
Published: February 2023

AbstractCurrently, Global Navigation Satellite System (GNSS) Real-Time Kinematic positioning (RTK) and Precise Point Positioning (PPP) techniques are widely employed for real-time monitoring of landslides. However, both RTK and PPP monitoring techniques have their limitations, such as limited service coverage or long convergence times. PPP-RTK technique which integrates RTK and PPP is a novel approach for monitoring landslides with the advantages of rapid convergence, high-precision, and a wide service area. This study summarizes the limitations of RTK, PPP, and PPP-RTK monitoring techniques and suggests some improved strategies. Their performances are compared and analyzed using real monitoring data. The experiment results demonstrate that RTK is the best option for small-scale (the baseline distance < 15 km) and real-time landslide monitoring without considering the cost. PPP technique converges to centimeter-level accuracy in tens of minutes, only suitable for the stability analysis of reference stations. Over a large area (the baseline distance < 100 km), PPP-RTK can provide excellent horizontal accuracy and adapt the service range in response to the demand for monitoring accuracy, as the vertical accuracy is significantly impacted by the service range and elevation difference. Finally, the characteristics of three techniques are integrated to form a comprehensive landslide monitoring technique that considers intelligence, robustness, and real-time.
Evaluation of protein C and S levels in patients with COVID-19 infection and their relation to disease severity
Authors: Elshafie Ahmed , Foda Enas , Yousef Mahmoud M. G. , El-Naby Kareem A. Abd 
Published: February 2023

Abstract
Background
The COVID-19 pandemic has been associated with millions of deaths around the world. One of the important causes of death associated with COVID-19 was pulmonary thromboembolism. The risk for venous thromboembolism was markedly increased in patients with COVID-19 especially those admitted to the intensive care unit. The aims of our study were to measure the protein C and S levels in COVID-19-infected patients in comparison with the normal population and to assess the correlation of protein C and S levels in the plasma to the severity of infection.

Methods
This was a case–control study measuring the protein C and S levels in patients infected with COVID-19 at the time of diagnosis compared to the normal population. The study included one hundred participants, sixty of them are patients with COVID-19, and forty of them are normal healthy adults. The patient group was subclassified into three subgroups according to disease severity: mild, moderate, and severe COVID-19 infections.

Results
The activity of protein C in the patient group serum was significantly lower than that in the control group serum (79.35 ± 26.017 vs 97.43 ± 15.007; p < 0.001). Protein S is also significantly decreased in patients’ serum when compared to the control group (70.233 ± 22.476 vs 91 ± 14.498; p < 0.001). There was a statistically significant decrease in the levels of protein C and S associated with the increase in disease severity (p < 0.05). However, protein S showed no statistically significant difference between the moderate and severe disease subgroups.

Conclusion
The study concluded that the levels of protein C and S activities were both decreased in patients with COVID-19 when compared to the healthy population. It also concluded that the decrease in their levels is statistically significant in relation to the disease severity.
Association of self-reported mother–infant relationship with child and adolescent mental health
Authors: Rasmussen Ida Scheel , Wilson Philip , Overbeck Gritt , Strandberg-Larsen Katrine 
Published: February 2023

Background
The quality of the relationship between mother and infant may have profound implications for the development of a child. Early indicators of psychological vulnerability may allow targeting of support for the child's cognitive, emotional and social development. A challenging mother–infant relationship could be one indicator of risk.

Aims
This study examined variations in psychological well-being and psychopathology among boys and girls according to early maternal perception of the mother–infant relationship.

Method
This study is based on 64 663 mother–infant pairs from the Danish National Birth Cohort, for which data on the mother–infant relationship were collected at 6 months postpartum. Behavioural problems were assessed with the Danish version of the Strengths and Difficulties Questionnaire (SDQ) at child ages 7, 11 and 18 years, and we retrieved information on diagnosed childhood and adolescent psychiatric disorders and prescriptions of psychotropic drugs from Danish registries.

Results
Children in the challenging mother–infant relationship group had higher odds of behavioural problems at age 7 among both boys and girls. The same pattern of elevated estimates was identified for boys across all SDQ domains and for girls in three of five SDQ domains. All associations were attenuated at age 18, but increased odds of behavioural problems still existed. A challenging early mother–infant relationship increased the offspring's risk of being diagnosed with a psychiatric disorder or being prescribed a psychotropic drug before the age of 18.

Conclusion
A challenging self-reported mother–infant relationship was associated with later psychopathological difficulties. Routine clinical enquiry may be useful in identification of future vulnerability.