bluuebunny/crossref_metadata_2025_split huggingface dataset:
A two-objective optimization of ship itineraries for a cruise company
Authors: Pillo Gianni Di , Fabiano Marcello , Lucidi Stefano , Roma Massimo 
Published: February 2023

AbstractThis paper deals with the problem of cruise itinerary planning which plays a central role in worldwide cruise ship tourism. In particular, the Day-by-day Cruise Itinerary Optimization (DCIO) problem is considered. Assuming that a cruise has been planned in terms of homeports and journey duration, the DCIO problem consists in determining the daily schedule of each itinerary so that some Key Performance Indicators are optimized. The schedule of an itinerary, i.e. the sequence of visited ports, the arrival and departure time at each port, greatly affect cruise operative costs and attractiveness. We propose a Mixed Integer Linear Programming (MILP) formulation of the problem with the objective of minimizing the itinerary cost due to fuel and port costs, while maximizing an itinerary attractiveness index. This latter is strongly related to the ports visited as well as to the overall schedule of the itinerary. Therefore the problem turns out to be a bi-objective optimization problem. We provide its solution in terms of Pareto optimal solution points. Each single objective MILP problem which arises is solved by using an exact algorithm, implemented in a commercial solver. We consider the day-by-day itineraries of a major luxury cruise company in many geographical areas all over the world. Here we report, as illustrative examples, the results obtained on some of these real instances.
Materials, fuels, upgrading, economy, and life cycle assessment of the pyrolysis of algal and lignocellulosic biomass: a review
Authors: Osman Ahmed I. , Farghali Mohamed , Ihara Ikko , Elgarahy Ahmed M. , Ayyad Amir , Mehta Neha , Ng Kim Hoong , Abd El-Monaem Eman M. , Eltaweil Abdelazeem S. , Hosny Mohamed , Hamed Seham M. , Fawzy Samer , Yap Pow-Seng , Rooney David W. 
Published: February 2023

AbstractClimate change issues are calling for advanced methods to produce materials and fuels in a carbon–neutral and circular way. For instance, biomass pyrolysis has been intensely investigated during the last years. Here we review the pyrolysis of algal and lignocellulosic biomass with focus on pyrolysis products and mechanisms, oil upgrading, combining pyrolysis and anaerobic digestion, economy, and life cycle assessment. Products include oil, gas, and biochar. Upgrading techniques comprise hot vapor filtration, solvent addition, emulsification, esterification and transesterification, hydrotreatment, steam reforming, and the use of supercritical fluids. We examined the economic viability in terms of profitability, internal rate of return, return on investment, carbon removal service, product pricing, and net present value. We also reviewed 20 recent studies of life cycle assessment. We found that the pyrolysis method highly influenced product yield, ranging from 9.07 to 40.59% for oil, from 10.1 to 41.25% for biochar, and from 11.93 to 28.16% for syngas. Feedstock type, pyrolytic temperature, heating rate, and reaction retention time were the main factors controlling the distribution of pyrolysis products. Pyrolysis mechanisms include bond breaking, cracking, polymerization and re-polymerization, and fragmentation. Biochar from residual forestry could sequester 2.74 tons of carbon dioxide equivalent per ton biochar when applied to the soil and has thus the potential to remove 0.2–2.75 gigatons of atmospheric carbon dioxide annually. The generation of biochar and bio-oil from the pyrolysis process is estimated to be economically feasible.
Nanoparticle-mediated cancer cell therapy: basic science to clinical applications
Authors: Verma Jaya , Warsame Caaisha , Seenivasagam Rajkumar Kottayasamy , Katiyar Nirmal Kumar , Aleem Eiman , Goel Saurav 
Published: February 2023

AbstractEvery sixth person in the world dies due to cancer, making it the second leading severe cause of death after cardiovascular diseases. According to WHO, cancer claimed nearly 10 million deaths in 2020. The most common types of cancers reported have been breast (lung, colon and rectum, prostate cases), skin (non-melanoma) and stomach. In addition to surgery, the most widely used traditional types of anti-cancer treatment are radio- and chemotherapy. However, these do not distinguish between normal and malignant cells. Additional treatment methods have evolved over time for early detection and targeted therapy of cancer. However, each method has its limitations and the associated treatment costs are quite high with adverse effects on the quality of life of patients. Use of individual atoms or a cluster of atoms (nanoparticles) can cause a paradigm shift by virtue of providing point of sight sensing and diagnosis of cancer. Nanoparticles (1–100 nm in size) are 1000 times smaller in size than the human cell and endowed with safer relocation capability to attack mechanically and chemically at a precise location which is one avenue that can be used to destroy cancer cells precisely. This review summarises the extant understanding and the work done in this area to pave the way for physicians to accelerate the use of hybrid mode of treatments by leveraging the use of various nanoparticles.
Capturing writers’ typing while visually attending the emerging text: a methodological approach
Authors: Wengelin Åsa , Johansson Roger , Frid Johan , Johansson Victoria 
Published: February 2023

AbstractKnowledge about writers’ eye movements and their effects on the writing process, and its product—the finally edited text—is still limited. Previous research has demonstrated that there are differences between reading texts written by someone else and reading one’s own emerging text and that writers frequently look back into their own texts (Torrance et al. in Psychol Res Psychologische Forschung 80(5):729–743, 2016.https://doi.org/10.1007/s00426-015-0683-8). For handwriting, Alamargot et al. (Writing and cognition: research and applications. Elsevier Science, pp 13–29, 2007) found support that these lookbacks could occur in parallel with transcription, but to our knowledge this type of parallel processing has not been explored further, and definitely not in the context of computer writing. Considering that language production models are moving away from previous sequential or serial models (e.g., Levelt in Speaking from intentions to articulation. MIT Press, 1989) towards models in which linguistic processes can operate in parallel (Olive in J Writ Res, 2014.https://doi.org/10.17239/jowr-2014.06.02.4), this is slightly surprising. In the present paper, we introduce a methodological approach to examine writers’ parallel processing in which we take our point of departure in visual attention rather than in the keystrokes. Capitalizing on New ScriptLog’s feature to link gaze with typing across different functional units in the writing task, we introduce and describe a method to capture and examine sequences of typing during fixations, outline how these can be examined in relation to each other, and test our approach by exploring typing during fixations in a text composition task with 14 competent adult writers.
Chironomus sp. as a Bioindicator for Assessing Microplastic Contamination and the Heavy Metals Associated with It in the Sediment of Wastewater in Sohag Governorate, Egypt
Authors: Khdre Azza M. , Ramadan Somaia A. , Ashry Ali , Alaraby Mohamed 
Published: February 2023

AbstractThe consequences of plastic waste pollution have imposed wide global concerns. One of these consequences is the production of micro- and nanosized particles (MNPLs) from aged plastics. The problem of MNPLs is magnified by their potential to transport various contaminants due to their large surface area and other variable physiochemical properties. From this point on, it is important to know the real concentration of MNPLs in our environment and their potential to internalize wild organisms as well as transfer contaminants that are completely highlighted. As a result, our study is the first to detect MP pollution in the upper Egypt wastewater environment. It could be utilized as a baseline to estimate MP wastes and develop management techniques, particularly in Sohag Governorate. The concentration and characterization of MPs in sludge, water, Chironomus sp. larvae, and their tubes were studied in this work. Chironomus sp. is a reliable bioindicator prevalent in such contaminated environments, and it was used to demonstrate how MPs invade biological barriers. Our results found that red and blue polyester fibers are much more prevalent than other polymers, colors, and shapes of MPs. While each dry kilogram of wastewater sludge contains 310 ± 84 particles, this amount is reduced to 1.55 ± 0.7 per liter in the water column. Biologically, the present study succeeded in detecting the MPs inside the wild organism, with concentrations reaching 71 ± 21 and 4.41 ± 1.1 particles per gram wet weight in Chironomus sp. larvae and their tubes (chironomid tubes), respectively. The potential hazard of MPs stems from their propensity to transfer pollutants. At this point, our findings revealed a corresponding and significant concentration of various heavy metals (Cu, Pb, Cd, and Ni) detected in MPs or Chironomus sp. versus sludge. In conclusion, our findings not only proved the presence of MPs in wastewater but also demonstrated their ability to internalize cross-wild organisms, allowing toxins to accumulate inside their bodies, raising concerns about the possible health impacts of plastic pollution.
Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 1. Pituitary neuroendocrine tumor (PitNET)/pituitary adenoma
Authors: Tsukamoto Taro , Miki Yukio 
Published: February 2023

AbstractThe pituitary gland is the body’s master gland of the endocrine glands. Although it is a small organ, many types of tumors can develop within it. The recently revised fifth edition of the World Health Organization (WHO) classifications (2021 World Health Organization Classification of Central Nervous System Tumors and 2022 World Health Organization Classification of Endocrine and Neuroendocrine Tumors) revealed significant changes to the classification of pituitary adenomas, the most common type of pituitary gland tumor. This change categorized pituitary adenomas as neuroendocrine tumors and proposed the name to be revised to pituitary neuroendocrine tumor (PitNET). The International Classification of Diseases for Oncology behavior code for this tumor was previously “0” for benign tumor. In contrast, the fifth edition WHO classification has changed this code to “3” for primary malignant tumors as same to neuroendocrine tumor in other organs. Because the WHO classification made an important and significant change in the fundamental concept of the disease, in this paper, we will discuss the imaging diagnosis (magnetic resonance imaging, computed tomography, and positron emission tomography) of PitNET/pituitary adenoma in detail, considering these revisions as per the latest version of the WHO classification.
Gestaltungsansätze für die Einführung und Nutzung von Kollaborationsplattformen – zwei KMU-Fallstudien aus der IT-Branche
Authors: Klötzer Stefan , Boos Margarete 
Published: February 2023

ZusammenfassungDie Einführung und Nutzung von Kollaborationsplattformen zur Unterstützung der Zusammenarbeit in Teams und in der Organisation ist eine komplexe soziotechnische Gestaltungsaufgabe für Unternehmen. Im CollaboTeam-Projekt wurden zwei mittelständische Unternehmen der IT-Branche bei der Einführung von Kollaborationsplattformen für die Verbesserung der Team- und Projektarbeit begleitet. Es wurde untersucht, welche Strategien und Maßnahmen die Unternehmen nutzten, um die Anforderung der Arbeitsgestaltung bewältigen zu können. Der vorliegende Beitrag stellt das Modell für die Arbeit mit Kollaborationsplattformen vor und präsentiert konkrete Gestaltungsmaßnahmen aus den zwei IT-Fallstudien. Das Modell umfasst drei Ebenen: Strategie, bei der Ziele für den Einsatz der Kollaborationsplattformen definiert werden, Analyse, bei der die gegenwärtige Zusammenarbeit in Arbeitssystemen untersucht und Gestaltungsbedarf abgeleitet wird, und die Ebene Gestaltung, die im Fokus dieses Beitrags steht und bei der die Gestaltungsmaßnahmen in sechs Themenfeldern systematisiert werden. Es wurden N = 21 Leitfadeninterviews mit Führungskräften und Beschäftigten der KMU inhaltsanalytisch ausgewertet.
A Rare Case of Submandibular Actinomycosis
Authors: Bajpai Sanchit , Parvathareddy Navya , Bhat Sweekritha N , Shenoy S Vijendra 
Published: February 2023

AbstractActinomycosis is caused by actinomyces israelii, a gram positive nonacid fast, anaerobic, commensal bacterium within the oral cavity. Though it is a commensal in oral cavity, it seldom presents as cervicofacial actinomycosis. But there is limited access to literature proving cervicofacial actinomycosis existence so far. We report a case of 35 year old gentleman who presented with painless progressive neck swelling associated with pain while chewing food. On examination, 3.5*2.5 swelling was noted in right submandibular gland area, radiologically a foreign body was detected in the right submandibular gland. Mass was excised in toto and sent for HPE which revealed submandibular gland actinomycosis. Post operatively, patient was managed with long-term broad-spectrum beta lactams and was on regular follow-up. No evidence of recurrence/ fresh complaints noted till date. Although cervicofacial actinomycosis is rare and dangerous with debilitating complications, timely diagnosis and early intervention with broad spectrum antibiotics and surgical excision (if required) shows promising results with complete eradication of disease leaving no residues.
Buying-shopping disorder, impulsivity, emotional dependence and attachment in adolescents
Authors: Etxaburu Nerea , Momeñe Janire , Herrero Marta , Chávez-Vera María Dolores , Olave Leticia , Iruarrizaga Itziar , Estévez Ana 
Published: February 2023

AbstractIn recent years, several studies have shown that the incidence of buying-shopping disorder (BSD) is increasing. Impulsivity is one of the factors involved in its aetiology and is related to emotional dependence. In addition, early affective deprivation may trigger emotional dependence. The aims of the present study weresal: to compare the types of attachment, levels of emotional dependence, impulsivity and BSD according to sex; to determine whether the proposed relational model is fulfilled; and analyse possible differences in this model in terms of the sample’s sex. The sample consisted of 1498 adolescents (53.8% men and 46.2% women) from Ecuador whose age ranged from 14 to 18 years (M = 15.77, SD = 1.21). The results showed that a preoccupied attachment style is indirectly related to a higher risk of BSD due to emotional dependence when impulsivity levels are medium or high because emotional dependence is moderated by impulsivity. The study variables are related in the same way in men and women but boys show higher levels of preoccupied attachment, impulsivity, emotional dependence and BSD. This study gives us a clearer picture of how these variables are related and provides information that could be of great use in assisting people with BSD. This knowledge could be applied to improve both the treatment and prevention of this problem.
Removal of methylene blue from aqueous solution by coconut coir dust as a low-cost adsorbent
Authors: Al Ashik Abdullah , Rahman Md. Ataur , Halder Debadas , Hossain Md. Mufazzal 
Published: February 2023

AbstractAdsorption of methylene blue (MB) from its aqueous solution onto coconut coir dust was studied in batch method. Coconut coir dust was characterized before and after adsorption by FT-IR spectroscopy and scanning electron microscopy (SEM). Surface charge, pHzpcof the adsorbent was measured by the method suggested by Huang and Ostovic and was found to be 7.65 (± 0.05). Batch kinetic experiments were performed and effects of several operational parameters i.e., contact time, initial concentration, pH of the solution and temperature on adsorption process were investigated. The effect of pH on adsorption was examined using a MB solution of 31.98 mg L−1at 30 °C on coconut coir dust varying the pH range from 3.02 to 11.04. At basic condition, the uptake increased significantly and reached the maximum at pH 9.0. The batch adsorption model, based on the assumptions of the Lagergren’s pseudo-first order and the Ho’s pseudo-second order model were applied to investigate the kinetics of this adsorption process. The results showed that the kinetic data fit very well to the pseudo-second order kinetic model. The adsorption isotherms were determined at four different particle sizes which ranges from < 106 to 300 μm. Among them < 106 μm particle size was chosen for whole process because of comparatively good adsorption capacity. The adsorption isotherms at different temperatures maintaining pH at 7.68 were studied and results show that the amount adsorbed increases with the increase in the temperature under all conditions. The linear correlation coefficients indicate that the Langmuir isotherm best fitted with the experimental data. Thermodynamic parameters such as Gibbs free energy change (ΔG), enthalpy change (ΔH) and entropy change (ΔS) were calculated. The values of ΔH and ΔS were found to be + 30.16 kJ mol−1 and + 0.128 kJ mol−1K−1 , respectively. At pH 7.68, the present system was spontaneous and endothermic in nature. It was found that when the temperature was increased from 303 to 333 K, the ΔG value decreased.
A retrospective survey of patients with hereditary transthyretin-mediated (hATTR) amyloidosis treated with patisiran in real-world clinical practice in Belgium
Authors: De Bleecker Jan L. , Claeys Kristl G. , Delstanche Stéphanie , Van Parys Vinciane , Baets Jonathan , Tilleux Sébastien , Remiche Gauthier 
Published: February 2023

Abstract
Introduction
Hereditary transthyretin-mediated (hATTR) amyloidosis, a genetic disease caused by mutations in the transthyretin gene, leads to progressive sensory and autonomic neuropathy and/or cardiomyopathy and is associated with renal and ophthalmologic manifestations and a poor prognosis.

Methods
This is a retrospective study based on data collected from the medical records of patients with hATTR amyloidosis treated with patisiran between 01 July 2018 and 01 February 2021. Six Belgian neuromuscular reference centers participated, covering all patisiran-treated hATTR amyloidosis patients at the study time. This study was conducted to collect data requested in the context of the reimbursement of patisiran in Belgium.

Results
Thirty-one patients were diagnosed with hATTR amyloidosis with polyneuropathy, Coutinho stage 1 or 2, and eligible for active treatment during the data collection period. Of the hATTR amyloidosis patients treated with patisiran (n = 12), seven and five had polyneuropathy stages 1 and 2, respectively. Six patients had cardiac symptoms (New York Heart Association class 2 or above). Follow-up information was available for nine patients. Following patisiran treatment, eight patients showed stable or improved assessments for most neurological or cardiological parameters. Only one patient presented with worsening statuses at the end of the data collection period.

Conclusions
The patients with hATTR amyloidosis in Belgium have similar baseline demographics and disease characteristics to those studied in the patisiran APOLLO study and show a similar therapeutic response in the real-world, altering the expected disease progression in most patients.
On the conservation laws, Lie symmetry analysis and power series solutions of a class of third-order polynomial evolution equations
Authors: Gwaxa B. , Jamal Sameerah , Johnpillai A. G. 
Published: February 2023

AbstractIn the present paper, we consider a special class of third-order polynomial evolutionary equations. These equations, via Lie theory admit the same one-parameter point transformations which leave the equations invariant. Reductions with these invariant functions lead to highly nonlinear third-order ordinary differential equations. We use a power series to establish interesting solutions to the reduced equations, whereby recurrence relations occur and convergence of the series may be tested. Finally, the conserved vectors of the class are constructed.
Evolutionary multiobjective optimization via efficient sampling-based offspring generation
Authors: He Cheng , Li Lianghao , Cheng Ran , Jin Yaochu 
Published: February 2023

AbstractWith the rising number of large-scale multiobjective optimization problems from academia and industries, some evolutionary algorithms (EAs) with different decision variable handling strategies have been proposed in recent years. They mainly emphasize the balance between convergence enhancement and diversity maintenance for multiobjective optimization but ignore the local search tailored for large-scale optimization. Consequently, most existing EAs can hardly obtain the global or local optima. To address this issue, we propose an efficient sampling-based offspring generation method for large-scale multiobjective optimization, where convergence enhancement and diversity maintenance, together with ad hoc local search, are considered. First, the decision variables are dynamically classified into two types for solving large-scale decision space in a divide-and-conquer manner. Then, a convergence-related sampling strategy is designed to handle those decision variables related to convergence enhancement. Two additional sampling strategies are proposed for diversity maintenance and local search, respectively. Experimental results on problems with up to 5000 decision variables have indicated the effectiveness of the algorithm in large-scale multiobjective optimization.
A practical guide to Registered Reports for economists
Authors: Arpinon Thibaut , Espinosa Romain 
Published: February 2023

AbstractThe current publication system in economics has encouraged the inflation of positive results in empirical papers. Registered Reports, also called Pre-Results Reviews, are a new submission format for empirical work that takes pre-registration one step further. In Registered Reports, researchers write their papers before running the study and commit to a detailed data collection process and analysis plan. After a first-stage review, a journal can give an In-Principle-Acceptance guaranteeing that the paper will be published if the authors carry out their data collection and analysis as pre-specified. We here propose a practical guide to Registered Reports for empirical economists. We illustrate the major problems that Registered Reports address (p-hacking, HARKing, forking, and publication bias), and present practical guidelines on how to write and review Registered Reports (e.g., the data-analysis plan, power analysis, and correction for multiple-hypothesis testing), with R and STATA codes. We provide specific examples for experimental economics, and show how research design can be improved to maximize statistical power. Last, we discuss some tools that authors, editors, and referees can use to evaluate Registered Reports (checklist, study-design table, and quality assessment).