bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aspirin Suppresses Hepatic Glucagon Signaling Through Decreasing Production of Thromboxane A2
Authors: Dai Yufeng , Xu Ruijie , Wu Guanglu , Yin Zihao , Zhang Hao , Li Haitao , Chen Wei 
Published: January 2023

Abstract
Excessive hepatic glucose production (HGP) is a major cause of fasting hyperglycemia in diabetes, and antihyperglycemic therapy takes center stage. Nonsteroidal anti-inflammatory drugs, such as acetylsalicylic acid (aspirin), reduce hyperglycemia caused by unrestrained gluconeogenesis in diabetes, but its mechanism is incompletely understood. Here, we reported that aspirin lowers fasting blood glucose and hepatic gluconeogenesis, corresponds with lower thromboxane A2 (TXA2) levels, and the hypoglycemic effect of aspirin could be rescued by TP agonist treatment. On fasting and diabetes stress, the cyclooxygenase (COX)/TXA2/thromboxane A2 receptor (TP) axis was increased in the livers. TP deficiency suppressed starvation-induced hepatic glucose output, thus inhibiting the progression of diabetes, whereas TP activation promoted gluconeogenesis. Aspirin restrains glucagon signaling and gluconeogenic gene expression (phosphoenolpyruvate carboxykinase [PCK1] and glucose-6-phosphatase [G6Pase]) through the TXA2/TP axis. TP mediates hepatic gluconeogenesis by activating PLC/IP3/IP3R signaling, which subsequently enhances CREB phosphorylation via facilitating CRTC2 nuclear translocation. Thus, our findings demonstrate that TXA2/TP plays a crucial role in aspirin’s inhibition of hepatic glucose metabolism, and TP may represent a therapeutic target for diabetes.
Race, Insurance, and Sex-Based Disparities in Access to High-Volume Centers for Pancreatectomy
Authors: Williamson Catherine G. , Ebrahimian Shayan , Sakowitz Sara , Aguayo Esteban , Kronen Elsa , Donahue Timothy R. , Benharash Peyman 
Published: January 2023

Abstract
Background
With a large body of literature demonstrating positive volume-outcome relationships for most major operations, minimum volume requirements have been suggested for concentration of cases to high-volume centers (HVCs). However, data are limited regarding disparities in access to these hospitals for pancreatectomy patients.

Methods
The 2005–2018 National Inpatient Sample (NIS) was queried for all elective adult hospitalizations for pancreatectomy. Hospitals performing more than 20 annual cases were classified as HVCs. Mixed-multivariable regression models were developed to characterize the impact of demographic factors and case volume on outcomes of interest.

Results
Of an estimated 127,527 hospitalizations, 79.8% occurred at HVCs. Patients at these centers were more frequently white (79.0 vs 70.8%; p < 0.001), privately insured (39.4 vs 34.2%; p < 0.001), and within the highest income quartile (30.5 vs 25.0%; p < 0.001). Adjusted analysis showed that operations performed at HVCs were associated with reduced odds of in-hospital mortality (adjusted odds ratio [AOR], 0.43; 95% confidence interval [CI], 0.34–0.55), increased odds of discharge to home (AOR, 1.17; 95% CI, 1.04–1.30), shorter hospital stay (β, −0.81 days; 95% CI, −1.2 to −0.40 days), but similar costs. Patients who were female (AOR, 0.88; 95% CI, 0.79–0.98), non-white (black: AOR, 0.66; 95% CI, 0.59–0.75; Hispanic: AOR, 0.56; 95% CI, 0.47–0.66; reference, white), insured by Medicaid (AOR, 0.63; 95% CI, 0.56–0.72; reference, private), and within the lowest income quartile (AOR, 0.73; 95% CI, 0.59–0.90; reference, highest) had decreased odds of treatment at an HVC.

Conclusions
For those undergoing pancreatectomies, HVCs realize superior clinical outcomes but treat lower proportions of female, non-white, and Medicaid populations. These findings may have implications for improving access to high-quality centers.
The Impact of Implementing Islamic Guidance to Prevent Corruption in Financial Management of Company
Authors: Nanang Angel Cahya Raudhatul Jannah , Kaffah Kenichi Satria , Wahyunengsih Wahyunengsih 
Published: January 2023

Financial management is an important unit in the organization system. Financial management is the central for implementing organization activity. In the other hand, financial management in Indonesia often the corruption and manipulating financial data.
Transparency International Indonesia (February 2022) rate Indonesia at 96 from 180 country’s in the corruption perception index. So, the budget allocation in a program is not efficient and can have impact on the success of the program. Actually the government of Indonesia have been launching many policy to prevent the corruption. But until now, all policy is fail.This study aimed to analyze what’s the motifs behind corruption in financial management. and to analyze how to prevent corruption in financial management with Islamic guidance.
This research was used qualitative analyze. the qualitative method aim to describe and analyze character of informant relating to the impact of implementing Islamic guidance to prevent corruption in financial management. According Moleong (2012), research method qualitative is a research method which the results descriptive data in the form of words verbal messages from people whose behavior can observed by researcher. The collecting data method used interview method. Interview is a method of collecting data by asking questions something to someone who is an informant or respondent (Afifuddin, 2009).The interview have 36 questions to know experiences all informant and education received from they parents. We would like to analyze child experience in home, parents education in the golden age, study experience in the school, and work experience. The research result are implementing Islamic guidance since the child, can be prevent corruption when they work in a company. The Islamic guidance importantly pray in 5 times can be develop person to be the honest, obedience, and always on time. All of this nature will be prevent corruption by low moral. In addition, a good work environment and good roles can be impact to prevent corruption opportunity. Just like invironmen will be able to develop behavior the child.
A contribuição do ICMS socioambiental no estado de Pernambuco / The Contribution of Socioambiental ICMS in State of Pernambuco
Authors: Campos Hélio Silvio Ourém , Batista Joao , Melo Daniele De Castro Pessoa de 
Published: January 2023

Resumo O presente trabalho tem como objetivo estudar o ICMS Socioambiental, visando compreender como ocorreu sua instituição, os porquês de sua criação, bem como os critérios de distribuição aos municípios. Assim, analisou-se a sua finalidade e as consequências, advindas de sua aplicação prática e os impactos do repasse desse tributo na criação e manutenção de unidades de conservação, mormente no município de São Lourenço da Mata, inserido na Região Metropolitana do Recife, no Estado de Pernambuco. Pelo método de pesquisa empírica e bibliográfica, foi analisado esse imposto, dando um pouco de ênfase em sua história e ainda as principais medidas apresentadas pelos órgãos gestores, destinadas a contribuir para um meio ambiente mais equilibrado, com um caráter tributário extrafiscal. Como resultado, foi observada a carência de políticas públicas, no sentido de valorizar a redução do desmatamento e a falta de incentivos à conservação e à preservação dos recursos naturais. Conclui-se pelo entendimento de que a aplicação dos recursos do ICMS Socioambiental pode mitigar os impactos ambientais a partir de iniciativas que possam criar novas unidades de conservação, além de manter as existentes, tudo associado ao nível de desenvolvimento e à valoração das questões ambientais. Esse foi o escopo que se percorreu na presente pesquisa.Palavras-chave: ICMS Socioambiental. Conservação. Preservação. Compensação. Sustentabilidade. Abstract The present study studies the Socioenvironmental ICMS, and aims to understand how its institution occurred, the objectives for which it was created, as well as what are the criteria of distribution to the municipalities. Thus, we analyze its purpose and the consequences of its practical application, and verify the impacts of the transfer of this tax on the creation and maintenance of conservation units, especially in the municipality of São Lourenço da Mata, located in the metropolitan region of Recife, Of Pernambuco, the object of our analysis. Through the method of empirical and bibliographical research, we analyze this tax, showing a little of its history, and also the main measures presented by the management bodies, designed to contribute to a more balanced environment, with a extrafiscal tax. As a conclusion, we note the lack of public policies, in order to value the reduction of deforestation, and the lack of incentives for conservation, and the preservation of natural resources. In this sense, we understand that the application of ICMS Socioenvironmental resources can mitigate the environmental impacts, starting with initiatives that may create new conservation units, in addition to maintaining existing ones, all associated to the level of development and valuation of environmental issues. This is the scope of this research.Keywords: Socio-environmental ICMS. Conservation. Preservation. Compensation. Sustainability.
A inefetividade da desapropriação e das ZEIS na redução déficit habitacional urbano / The ineffectiveness of expropriation and ZEIS in reducing urban housing deficit
Authors: Silveira Suzana Maria Loureiro , Mastrodi Josué , Rossi Renan Alarcon 
Published: January 2023

ResumoEste texto compõe a segunda parte de um trabalho voltado ao estudo e à promoção das funções sociais da cidade e da propriedade a partir da aplicação dos instrumentos urbanísticos previstos no direito brasileiro. Afirmamos que o planejamento urbano só confere função social à cidade se houver radical transformação das áreas privadas, de modo a reduzir, senão eliminar os vazios urbanos, existentes pela prática do uso antissocial do direito à propriedade. Nesta segunda parte, tratamos especificamente dos instrumentos de política urbana denominados Desapropriação e Zonas Especiais de Interesse Social (ZEIS) e de como podem ser aplicados para a promoção de um direito à cidade, por definição includente, em oposição a uma cidade ordenada tradicionalmente a partir de regras de um direito civil que exclui.Palavras-chave. Direito à cidade. Planejamento urbano. Função Social. Desapropriação. Zonas Especiais de Interesse Social. AbstractThis paper composes the second part of a research focused on the study and promotion of the social functions of the city and of the property, based on the application of urban planning instruments set forth in Brazilian Law. We affirm that urban planning only confers a social function to the city if there is radical transformation of the private areas, in order to reduce, if not to eliminate, the urban voids, existing by the practice of antisocial use of the right to property. In this second part, we deal specifically with the urban policy instruments called Expropriation and Special Zones of Social Interest (ZEIS, in the acronym in Portuguese) and how they can be applied to promote a right to the city, by definition inclusive, as opposed to the rules of Civil Law, which are traditionally excluding.Keywords: Right to the city. Urban Planning. Social function. Expropriation. Special Zones of Social Interest.
"Livrai-nos de todo mal": medo, controle social e segregação espacial / "Freedom Of All Evil": Fear, Social Control And Space Segregation
Authors: Wermuth Maiquel Ângelo Dezordi , De Campos Paula Bohn 
Published: January 2023

ResumoO artigo aborda o elemento “medo” como ferramenta histórica de estabilização e controle para manutenção da “ordem” social, pontuando, sobretudo, quais os elementos socioeconômicos e culturais que subjazem a esta dominação política e econômica. Além disso, analisa a influência dos meios midiáticos na propagação do senso comum acerca da criminalidade, na busca de tentar entender quais são os seus reais impactos no imaginário coletivo, bem como as reações sociais que daí advêm. Por fim, investiga o processo de marginalização dos espaços públicos e de estigmatização social das classes periféricas pelas classes dominantes. O enfoque principal, portanto, está centrado na violência estrutural e nos interesses socioeconômicos como ponto crucial de encarceramento dos indivíduos “indesejáveis” e das frequentes violações de direitos destes indivíduos, com a imposição de um ciclo de exclusão social e subordinação. O método empregado na investigação é o fenomenológico hermenêutico.Palavras-chave: Controle Social. Medo. Criminalização da pobreza. Sistema punitivo. Segregação social. AbstractThe article deals with the element of fear as a historical stabilization and control tool for the maintenance of social order, highlighting, above all, the socioeconomic and cultural elements that underlie this political and economic domination. In addition, it analyzes the influence of the media in the spread of common sense about criminality, in the search to try to understand what their real impacts on the collective imaginary, as well as the social reactions that follow. Finally, it investigates the process of marginalization of the public spaces and of social stigmatization of the peripheral classes by the dominant classes. The main focus, therefore, is on structural violence and socio-economic interests as a crucial point of incarceration of undesirable individuals and the frequent violations of rights of these individuals, with the imposition of a cycle of social exclusion and subordination. The method employed in the investigation is the phenomenological hermeneutic.Keywords: Social Control. Fear. Criminalization of poverty. Punitive system. Social segregation.
A progressividade do imposto de renda pessoa física à luz do princípio da capacidade contributiva: instrumento auxiliar na busca da redução das desigualdades e exclusões sociais no Brasil
Authors: Kuntz Tatiele Gisch , Rodrigues Hugo Thamir 
Published: January 2023

ResumoA tributação do imposto sobre a renda das pessoas físicas, além de ser uma importante fonte de arrecadação para os cofres do Estado, pode e deve ser compreendida como um meio para efetivação dos objetivos fundamentais da República. Nessa perspectiva, considerou-se oportuna a elaboração de um estudo com o objetivo de verificar se a progressividade do imposto de renda pessoa física, à luz do princípio da capacidade contributiva, pode configurar como um instrumento de política pública atenuante das desigualdades sociais no Brasil. Para exame do proposto, optou-se por um estudo de cunho qualitativo, com a interpretação e análise dos dados por meio da técnica de pesquisa bibliográfica. O método de abordagem empregado foi o indutivo e o método de procedimento o monográfico. Conclui-se, por conseguinte, que apesar de haver um longo caminho a ser percorrido no sentido de se efetivar a justiça social por intermédio da fiscal no Brasil, a progressividade do imposto sobre a renda das pessoas físicas, fundada no princípio da capacidade contributiva, pode ser vista como um mecanismo de concretização do princípio da igualdade material e, consequentemente, dos objetivos fundamentais do Estado Democrático de Direito, em especial, aqueles que dizem respeito a redução das desigualdades sociais e a melhoria da redistribuição de renda.Palavras-Chave: Capacidade contributiva. Imposto de renda das pessoas físicas. Justiça fiscal. Progressividade. Redução das desigualdades sociais. AbstractThe taxation on personal income, besides being an important source of income for the state, can and should be understood as a mechanism of putting into effect fundamental goals of the Republic. In this perspective, it was considered appropriate the elaboration of a study with the goal of verifying if the progressivity of personal income tax, in light of the principle of the contributory capacity, may configure as an instrument of public policy reducing social inequalities in Brazil. For examination of the proposed, it was opted for a qualitative study, with the interpretation and analysis of data by means of a bibliographic research technique. The method of approach used was the inductive and the method of procedure the monographic. In conclusion, therefore, that even though there is a long way to go in the sense of effecting social justice through the fiscal in Brazil, the progressivity of taxes on personal income, founded on the principle of contributory capacity, may be seen as a mechanism of concretization of the principle of material equality and consequently, of the fundamental goals of a Democratic State, in particular, those that refer to the reduction of social inequality and the improvement of income redistribution.Keywords: Contributory capacity. Personal income tax. Fiscal justice. Progressivity. Reduction of social inequalities.
O modelo de processo coletivo no Conselho Nacional de Justiça: a problemática jurídica da escritura pública declaratória de união poliafetiva
Authors: Costa Fabricio Veiga 
Published: January 2023

ResumoO objetivo geral da pesquisa é investigar o processo que tramitou no Conselho Nacional de Justiça, proibindo a lavratura de escritura pública declaratória de uniões poliafetivas, problematizando a questão proposta na perspectiva do modelo de processo coletivo democrático-participativo. A escolha do tema se justifica em razão da necessidade de verificar a legitimidade jurídica do CNJ em apreciar a temática proposta, bem como o debate sobre o déficit de participação popular na formação dialética do mérito processual. Foram analisadas as 5 (cinco) teses jurídicas trabalhadas pelos conselheiros, no sentido de demonstrar que a decisão proferida é autocrática por não permitir que os destinatários do provimento final pudessem participar da formação discursiva do conteúdo decisório, haja vista a não realização de audiências públicas. Por meio da pesquisa bibliográfica e documental foi possível construir análises temáticas, teóricas, interpretativas e comparativas, a fim de demonstrar criticamente a ilegitimidade jurídica do CNJ proibir a lavratura de escritura pública declaratória de união poliafetiva, além do déficit de democraticidade do provimento estatal face a ausência de participação popular.Palavras-Chaves: Conselho Nacional de Justiça. Modelo de Processo Coletivo. Poliafetividade. Escritura Pública Declaratória. Processo Coletivo Participativo. AbstractThe general objective of the research is to investigate the process that went through the National Council of Justice, prohibiting the drawing up of public declaratory deed by poly-affective unions, problematizing the question proposed in the perspective of the model of collective- democratic process. The choice of the theme is justified due to the need to verify the legal legitimacy of the CNJ in assessing the proposed theme, as well as the debate about the deficit of popular participation in the dialectical formation of procedural merit. The 5 (five) legal theses worked by the counselors were analyzed, in order to demonstrate that the decision rendered is autocratic because it does not allow the recipients of the final provision to participate in the discursive formation of the decision content, in view of the non-holding of public hearings. Through bibliographic and documentary research it was possible to construct thematic, theoretical, interpretative and comparative analyzes, in order to critically demonstrate the legal illegitimacy of the CNJ to prohibit the drawing up of a public declaratory deed for a poly- affective union, in addition to the deficit in the democratic provision of the state in the face of absence of popular participation.Keywords: National Council of Justice. Collective Process Model. Polyaffectivity. Declaratory Public Deed. Collective Participatory Process.
Gestação de substituição em tempos de COVID-19: uma pandemia no caminho dos direitos fundamentais
Authors: Amaro Mylene Manfrinato dos Reis , Cardin Valéria Silva Galdino 
Published: January 2023

ResumoOs direitos reprodutivos são direitos da personalidade fundados no livre planejamento familiar e podem ser exercidos por meio da gestação por substituição estrangeira. A pandemia da COVID-19 impôs restrições à liberdade de locomoção, o que impactou no direito de pessoas ou casais, cujos projetos parentais estavam em andamento no exterior, buscar(em) seus filhos em outros países. Diante disso, a presente pesquisa objetiva analisar a violação aos direitos da personalidade de crianças oriundas de gestação por substituição estrangeira e propor soluções para evitar que situações como essas ocorram. Para tanto, a metodologia utilizada foi o método indutivo, mediante pesquisa bibliográfica e documental, sistematizada em categorias de análise. Verifica-se que a restrição ao direito de locomoção imposto pela pandemia da COVID-19 causou prejuízo ao direito à cidadania, à nacionalidade e ao direito de convivência dos filhos em relação aos pais e expôs a situação da mercantilização da vida humana. Propõe-se como soluções: estabelecer convivência presencial de sessenta dias antes do parto entre os pais e a prole (pela gestante); e criar uma regra excepcional para que, em caso de fechamento de fronteiras dos países que permitem o turismo reprodutivo, se permita a entrada de pais estrangeiros que possuem projetos parentais em andamento.Palavras-chave: COVID-19; Direitos da Personalidade, Gestação por Substituição Estrangeira; Livre Planejamento Familiar; Melhor Interesse da Criança. AbstractThe reproductive rights are personality rights based on free family planning and can be exercised through foreign surrogacy. The COVID-19 pandemic has imposed restrictions on people’s freedom of movement, which has impacted the right of individuals or couples whose parenting projects were underway abroad to seek out their children in other countries. The present research aims to analyze the violation of the personality rights of children resulting from foreign surrogacy and to propose solutions to prevent situations like these from occurring. The methodology used was the inductive method, through bibliographic and documental review, systematized in categories of analysis. The restriction on the right to locomotion imposed by the COVID-19 pandemic caused damage to the right to citizenship, nationality and the right to coexistence of children in relation to their parents and exposed the situation of the mercantilization of human life. It is proposed as solutions: establish face-to-face coexistence sixty days before delivery between parents and offspring (by pregnant women); and create an exceptional rule so that, in the event of the closure of borders of countries that allow reproductive tourism, foreign parents who have parental projects in progress are allowed.Keywords: COVID-19; Personality Rights; Foreign Surrogacy; Free Family Planning; Child’s best interest.