bluuebunny/crossref_metadata_2025_split huggingface dataset:
IVSE: Indian Voice Separation and Enhancement from a cocktail party scenario
Authors: Gupta Monika , Singh R. K. , Singh Sachin 
Published: March 2023

Abstract
Audio bots like Alexa, Siri, Google assistant, require a clean voice to perform a task. These bots ignore a disturbance or mixed voice. We get the famous message “sorry I could not understand”. With the introduction of smart homes and smart cities, it is imperative for devices to understand the commands in a noisy environment and that too in a native language. Indian Voice Separation and Enhancement (IVSE) offer the solution. For separation and enhancement of voice, the model should filter the noise first. For eliminating zero and negative values, a Zero-Negative filter (ZNF) is created. To eliminate the rippling effect induced by the time domain or frequency domain filters, Enhance Voice Function (EVF) enhances the voice. The output is windowed into different frames of equal lengths. Then it is labelled as noise and clean signals. A gradient boosting algorithm-based approach is then applied to filter the noise. The 50,000 voiceprints from the filtered voice were used to construct a training and validation set. For predictive analysis, the dataset is divided into an 80:20 ratio. IVSE uses LightGBM to create distinctive voiceprints. LightGBM operates in the background on Tensor Flow, which improves its performance. The paper compares IVSE and different benchmark algorithms at the end.
Uterine Leiomyosarcoma with a Novel RAB2A-PLAG1 Gene Fusion
Authors: Sham Sunder , Hosseini Hossein , Kokabee Mostafa , Bendari Ahmed , Reham Al-Refai , Zhong Xuelin , Vele Oana , Villella Jeannine A. , Unger Pamela , O'Leary Xiaoqing , Benhamidam Jamal K. 
Published: March 2023

Abstract
Uterine leiomyosarcoma (ULMS) is the most common subtype of uterine sarcoma and constitutes 1% of all uterine malignancies. In some cases, distinguishing ULMS from endometrial stromal sarcoma (ESS) can be challenging because they may display histological and immunohistochemical overlaps. In such cases, molecular studies such as RNA sequencing to detect gene rearrangements can help arrive at a definitive diagnosis. We report a unique case of ULMS with a novel RAB2A-PLAG1 gene fusion. To our knowledge, this is the first reported case in English literature.
Case Presentation:
An 80-year-old woman presented to our hospital with a one-month history of pelvic pain and abnormal uterine bleeding. Imaging was notable for a large necrotic uterine mass, thickened endometrium, and uterine fibroids. Subsequent endometrial biopsy (EMB) revealed an unremarkable transformation zone of the epithelium. After four months, the patient presented with persistent symptoms. A solid mass within the endometrium was observed on the imaging. Endometrial curettage (EMC) revealed a malignant uterine mesenchymal neoplasm, with histological findings suggestive of ULMS and ESS. The patient underwent a total hysterectomy with bilateral salpingo-oophorectomy. Immunohistochemical analysis of the resected specimen was inconclusive. RNA sequencing revealed a novel RAB2A-PLAG1fusion, and ULMS was diagnosed.
Conclusion:
This is the first case of ULMS with a RAB2A-PLAG1 gene fusion. Pathologists should be aware of the extensive morphological and immunophenotypic overlap between the various uterine mesenchymal neoplasms. In challenging cases, molecular studies are crucial for pathologists to arrive at a final diagnosis.
Dialectical Behavior Therapy in suicidal patients with borderline personality disorder: A pilot randomized controlled trial in Taiwan
Authors: Wu Shu-I , Huang Hui-Chun , Chen Joya Shu-Chin , Korslund Kathryn , Lin Chen-Ju , Lin Ying , Chang Yi-Hung , Yeh Hsiao-Mei , Lin I-Chieh , Lin Yu-Wen , Sun Fang-Ju , Liu Shen-Ing 
Published: March 2023

AbstractBackground:Borderline personality disorder (BPD) is associated with considerable morbidity and mortality. Suicidality and self-injury are common. This study aimed to examine the implementation of Dialectical Behavior Therapy (DBT) in the local Chinese sample.Method:This is a single-blind randomized controlled trial recruited patients diagnosed with BPD with at least two episodes of suicidal or non- suicidal self-injurious episodes in the past 5 years. These patients were randomly assigned to one year of either DBT or psychotherapy delivered by community treatment experts in suicide prevention. Primary outcomes, assessed at 4-month intervals over the treatment year, were frequency of suicide attempts and episodes of non- suicidal self-injury. Psychological distress including depression, anxiety, hopelessness, suicidal ideations, and quality of life were also measured.Results:Of the 150 patients with borderline personality disorder referred and screened, 60 participated in the trial. Reductions in self-harm behaviors, medical utilizations due to suicidal ideations or suicidal attempts, borderline symptoms, and psychological distress were found in both groups. However, no between-group differences were noted at the end of treatments.Conclusions:Our results suggest that BPD patients with suicidal attempts in a publicly funded health care system with limited resources benefited equally from DBT and treatment delivered by suicide prevention experts in Taiwan.Trial registration:Clinical Trial IdentifierNCT01952405. First Submitted: September 6, 2013
Molecular characterization and antifungal activity of lipopeptides produced from Bacillus subtilis against plant fungal pathogen Alternaria alternata
Authors: N Harish B , N Nagesha S , N Ramesh B , S Shyamalamma , S Nagaraj M , C Girish H , C Pradeep , S Shiva Kumar K , S Tharun Kumar K , N Pavan S , V Kavan Kumar 
Published: March 2023

Abstract
Alternaria alternata is a fungus that has been recorded to cause leaf spots on over 380 host species of plant. It is an opportunistic pathogen on numerous hosts causing leaf spots, rots, and blights on many plant parts. This study aimed to investigate the antifungal activity of the lipopeptides from strains (T3, T4, T5, and T6) of B. subtilis were studied. The genomic DNA was isolated from B. subtilis bacteria and confirmed the presence of iturin, surfactin, and fengycin genes by PCR amplification. Antifungal Lipopeptides were extracted, identified by HPLC, and quantified from B. subtilis strains with the values for T3 (24µg/ml), T4 (32µg/ml), T5 (28µg/ml) and T6 (18µg/ml). The extracted lipopeptides from T3, T4, T5, and T6 strains of B. subtilis at 10µg/ml of media were used against Alternaria alternata to check the antifungal activity. The rate of inhibition using lipopeptides against Alternaria alternata was recorded as T3 (75.14%), T4 (75.93%), T5 (80.40%), and T6 (85.88%). Among the four strains, the T6 strain (85.88%) showed the highest antifungal activity against the Alternaria alternata.
Identification of the Expression Patterns and Potential Prognostic Role of m6A-RNA Methylation Regulators in Wilms Tumor
Authors: Jia Changlin , Gao Hongjie , Ma Wenyue , Liu Xiaoya , Chang Mengmeng , Sun Fengyin 
Published: March 2023

Abstract
Background. To explore the potential role of m6A methylation modification in Wilms Tumor (WT) by m6A-RNA Methylation (m6A) regulators.
Methodology. The association of m6A modification patterns with immune and prognostic characteristics of tumors was systematically evaluated using 19 m6A regulators extracted from Wilms Tumor’s samples in public databases. A comprehensive model of "m6Ascore" was constructed using principal component analysis, and its prognostic value was evaluated.
Results. Almost all m6A regulators were differentially expressed between WT and normal tissues. Unsupervised clustering identified three distinct m6A clusters that differed in both immune cell infiltration and biological pathways. The m6Ascore was constructed to quantify m6A modifications in individual patients. Our analysis suggests that m6Ascore is an independent prognostic factor for WT and can be used as a novel predictor of WT prognosis.
Conclusions.This study comprehensively explored and systematically characterized m6A modifications in WT. m6A modification patterns play a critical role in the tumor immune microenvironment (TIME) and WT prognosis. m6Ascore provides a more comprehensive understanding of m6A modifications in WT and offers a practical tool for predicting WT prognosis. This study will help clinicians to identify valid indicators of WT to improve the poor prognosis of this disease.
Smallholder Farmers Adoption of Climate Smart Livestock Production: Practices, Status and Determinants in Hidebu Abote Woreda, Central Ethiopia
Authors: Ayal Desalegn , Mamo Bassa 
Published: March 2023

Abstract

This study aimed at identifying the status, determining factors, and challenges in adopting climate smart livestock production practices by smallholder farmers. Three-staged sampling techniques were used to select the targeted area and 233 sample smallholder farmers respondents. Data were collected mainly using a pre-tested structured questionnaire. Key informant interviews and focus group discussions were also conducted to complement the household survey data. Various descriptive statistics were applied to analyze the collected survey data. An ordered logistic regression model was used to analyze the determinant factors which affect the adoption status of the sampled smallholder farmers. The result revealed that the most adopted practices were composting (85.41%) and manure management (70.39%) while the least adopted technologies were biogas generation (3.86%) and rotation grazing (22.32%). The adoption status of the sampled smallholder farmers was also categorized into low (19.74%), medium (67.81%), and high adopter (12.45%). The high cost of improved breed, use of manure for fuel, free grazing, lack of information and awareness were the major constraints to adopting the technology. The result also revealed that education, grazing land, total livestock holding, and extension agent contact contributed significantly and positively to the adoption status, while the distance from the water source had an insignificant and negative effect on the adoption status of climate smart livestock production practices.
Does the birth plan match what is relevant to women? Women's preferences when giving birth
Authors: Artieta-Pinedo Isabel , Paz-Pascual Carmen , Garcia-Alvarez Arturo , Bully Paola , Group ema.Q , Espinosa Maite 
Published: March 2023

Abstract
Background: To support women in making shared decisions, it is important to know what is relevant to them. The aim is to explore which of the options included in birth plans are of most interest to women, and whether the variability is associated with personal characteristics
Methods: Participants were asked about their degree of agreement with statements about delivery environment, accompaniment, pain relief, medical intervention and neonatal care. The relationship between agreement with each statement, sociodemographic variables and fear of childbirth (W-DEQ-A) was analysed.
Results: 247 women responded. More than 90% preferred a hospital delivery, with information about and control over medical intervention, accompanied by their partner and continuous skin-to-skin contact with the newborn. There are other questions to which women attach less importance or which show greater variability in their responses; these are questions related to more clinical aspects. More than 30% had a neutral opinion on foetal monitoring, placenta delivery, or cord clamping. There are various factors that are related to this variability;parity, nationality, educational level, risk factor or fear of childbirth are the most important.
Conclusions: The birth plan currently on offer is only partly tailored to women's areas of interest. There are some issues, mostly identified as very important, that should form the basis of childbirth care rather than being an option: these are the aspects more connected to human relationships in childbirth. Other clinical issues, which present greater variability, must be offered for reflection, together with the information and support necessary for decision-making.
Decreasing per capita human capital growth in 166 countries from 1990 to 2020
Authors: Chen Shuning , PIAO Xiangdan , Xie Jun , Managi Shunsuke 
Published: March 2023

Abstract
Human capital is widely acknowledged as an inclusive resource that encompasses the knowledge and expertise of citizens, which propels economic development. This research integrates education data with demographic, health, and socioeconomic factors to construct a cross-country human capital monetary accounting framework. We evaluate the levels of educational attainment and the total adult population by stage of life expectancy. Subsequently, we assess education returns based on lifetime income and educational attainment. This accounting tracks the level and changes of human capital in 166 countries from 1990 to 2020, providing multiple indicators to measure human capital for sustainability. The primary findings indicate that globally, the growth trajectory of human capital has declined over the past decade, suggesting a threshold for human capital growth under current investment levels. Based on these findings, it is recommended that policymakers consider this shift and align long-term human capital investment with sustainable growth paths.
Change in skeletal muscle mass is associated with hepatic steatosis in nonalcoholic fatty liver disease
Authors: Jo Ik Hyun , Song Do Seon , Chang U Im , Yang Jin Mo 
Published: March 2023

Abstract
The association between nonalcoholic fatty liver disease (NAFLD) and sarcopenia is known. We aimed to determine the association between skeletal muscle mass changes and NAFLD status. This retrospective single-center study analyzed patients who underwent health screening twice between November 2009 and December 2017, with a temporal gap of 6 ± 0.5 years. The degree of sarcopenia was assessed using appendicular skeletal muscle mass (ASM) adjusted for weight and body mass index (BMI). Changes in hepatic steatosis and fibrosis status were evaluated using noninvasive serum markers. Patients with a decrease in ASM/BMI (n = 353) had increased hepatic steatosis index (HSI) and fatty liver index (FLI) scores during 6 years (p < 0.05). The baseline sarcopenia group had a greater elevation in NAFLD fibrosis score (NFS) over 6 years than those without baseline sarcopenia. ASM changes over 6 years showed a negative correlation with variations in HSI (β=-0.96 in ASM/Weight and − 28.93 in ASM/BMI) and FLI (β=-5.44 in ASM/Weight and − 167.12 in ASM/BMI). Subgroup analyses showed similar results according to sex and age. Sarcopenia may worsen steatosis and vice versa. Skeletal muscle status can be used to predict the course of NAFLD and establish individualized treatment strategies.
Current Research on Deposition and Drift of Droplets Sprayed by Plant Protection UAV
Authors: Qin Weicai , Chen Panyang 
Published: March 2023

Abstract
Plant protection UAV, which is highly adapted to terrain and capable of efficient low-altitude spraying, will be extensively used in agricultural production. This paper systematically sorts out the single or several independent factors influencing the deposition characteristics of droplets sprayed by plant protection UAV, as well as the experimental methods and related mathematical analysis models used to study the droplet deposition and drift. It proposes a research method based on farmland environmental factors to simulate the deposition and drift characteristics of pesticide droplets, further studies the impact of multiple factors on the droplet deposition characteristics by using an indoor simulation test system for the spraying flow field of plant protection UAV to simulate the plant protection UAV spraying flow field, temperature, humidity and natural wind and integrating the operation parameters, environmental conditions, crop canopy characteristics and rotor airflow, explores the main effects and interactive effects of the factors influencing the deposition of pesticide droplets, establishes a mathematical model which can reflect the internal relations of multiple factors and evaluate and analyze the droplet deposition characteristics, and further proposes a scientific and effective method for determining the optimal pesticide droplet deposition. In addition, it also proves that this research method can provide a necessary scientific basis for the formulation of operating standards for plant protection UAV in China, inspection and evaluation of operating tools at the same scale, and the improvement and upgrading of spraying systems.
Evaluation of upper limb perception after stroke: a prevalence and longitudinal study with the new Affected Limb Perception Questionnaire (ALPQ)
Authors: KONIK Stéphanie , BEAUD Valérie , FELLRATH Julia , MARTINELLI Isabella , GUANZIROLI Eleonora , MOLTENI Franco , BASSOLINO Michela , SERINO Andrea 
Published: March 2023

Abstract
Background

Following a stroke, patients may suffer from alterations in the perception of their own body due to an acquired deficit in body representations. While such changes may impact their quality of life as well as recovery, they are not systematically assessed in clinical practice. This study aims at providing a better understanding of the prevalence, evolution and impact on recovery of upper-limb body perceptions (BPs) alterations following stroke. In addition, we will investigate associations among BPs alterations items, their associations with the sensorimotor functions, upper-limb usage, damages in brain structure and connectivity.

Methods

We developed a new tool named ALPQ (for Affected Limb Perception Questionnaire) to address the present study objectives. It assesses subjective disturbances in the perception of the affected upper limb (UL) following stroke, by measuring several dimensions, namely: anosognosia for hemiplegia, anosodiaphoria for hemiplegia, hemiasomatognosia, somatoparaphrenia, personification of the affected limb, illusion of modification of physical characteristics (temperature, weight, length), illusory movements, super- or undernumerary limb, upper-limb disconnection, misoplegia, and involuntary movement. This study combines a cross-sectional and longitudinal design. The ALPQ will be administered to minimum 60 acute and 100 sub-acute stroke patients. When possible, patients will be followed up to the chronic stage. Complementary evaluations will be administered to assess patients’ sensorimotor and cognitive functions as well as upper-limb activity, and brain lesions will be analysed.

Discussion

The ALPQ is a new tool to evaluate patient’s body perceptions which has the advantages to cover a broad range of BPs distortions, to be compatible with the clinical context, and to have a quantitative approach. This study will provide a better understanding of BPs alterations following stroke: their prevalence and evolution, as well as their associations with sensorimotor deficit, cognitive profile and spontaneous arm activity, brain lesions and recovery. Ultimately, the results could support the personalization of rehabilitation strategy accordingly to patients’ UL perception to maximize their recovery.

Trial registration

https://osf.io/p6v7f.
Modeling Alzheimer’s disease in primary neurons reveals DNA damage response coupled with MAPK-DLK signaling in wild-type tau-induced neurodegeneration
Authors: Li Sanming , Roy Ethan R. , Wang Yanyu , Watkins Trent , Cao Wei 
Published: March 2023

Abstract
Background: Alzheimer’s disease (AD) is the most prevalent form of neurodegeneration. Despite the well-established link between tau aggregation and clinical progression, the major pathways driven by this protein to intrinsically damage neurons are incompletely understood.
Methods: To model AD-relevant neurodegeneration driven by tau, we overexpressed wild-type human tau in primary mouse neurons and characterized the subsequent cellular and molecular changes. RNAseq profiling and functional investigation were performed as well. A direct comparison with a mutant human tau was conducted in detail.
Results: We observed substantial axonal degeneration and cell death associated with wild-type tau, a process accompanied by activated caspase 3. Mechanistically, we detected deformation of the nuclear envelope and increased DNA damage response in tau-expressing neurons. Gene profiling analysis further revealed significant alterations in the mitogen-activated protein kinase (MAPK) pathway; moreover, inhibitors of dual leucine zipper kinase (DLK) and c-Jun N-terminal kinase (JNK) were effective in alleviating wild-type human tau-induced neurodegeneration. In contrast, mutant P301L human tau was less toxic to neurons, despite causing comparable DNA damage. Axonal DLK activation induced by wild-type tau potentiated the impact of DNA damage response, resulting in overt neurotoxicity.
Conclusions: We have established a cellular tauopathy model highly relevant to AD and identified a functional synergy between DNA damage response and the MAPK-DLK axis in the neuronal degenerative process.
Characterization of Upper Cretaceous Matulla and Wata clastic reservoirs from October field, Central Gulf of Suez, Egypt
Authors: Farouk Sherif , Sen Souvik , Saada Saada , Eldosouky Ahmed , Elsayed Romaisaa , Kassem Ahmed , Al-Kahtany Khaled , Abdeldaim Ahmed 
Published: March 2023

Abstract
This study discusses the petrographic and petrophysical characteristics of the shallow marine clastic reservoirs of the Coniacian-Santonian Matulla Formation and upper Turonian Wata Formation from the October oil field, Central Gulf of Suez Basin. Thin sections, SEM and XRD data indicate that the studied glauconitic subarkose quartz arenites of the Matulla and Wata reservoirs are fine to very fine-grained, moderately sorted, subrounded to subangular and exhibit good intergranular primary porosity with good pore connectivity. Moderate to slight compaction and grain to grain pressure solution resulted in a slightly inhomogeneous packing of framework grains. Feldspar dissolution contributed to the secondary porosity generation which enhanced the reservoir quality, while quartz overgrowth and minor calcite cementation are inferred as porosity destroying diagenetic agents. Pore-filling kaolinite and clay phases also had a negative effect on reservoir storage capacity. Routine core analysis indicated average > 20% porosity and good permeability (up to 412 mD) in the meso-megaporous sandstones of both the reservoirs. Permeability anisotropy analysis of Matulla samples indicates the dominance of primary depositional fabric and isotropic pores with minor scattered/connected horizontal pores and vertical pore connectivity. Wireline log-based assessments provided quantitative petrophysical properties which also exhibit low shale volume and higher hydrocarbon saturation (up to 80%). The same has also been deciphered from the gas chromatography data which confirms the presence of oil in the Matulla and Wata pay zones based on gas balance, wetness and character ratios. The study concludes excellent reservoir properties in the Upper Cretaceous clastic intervals of the October field.