bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring intersectoral collaboration in diabetes care: A positioning theoretical perspective
Authors: Andersen Anne Bendix , Frederiksen Kirsten , Laursen Henrik Sehested , Gravesen Janni Dahlgaard 
Published: July 2023

AbstractIntersectoral collaboration (IC) plays a significant role in the delivery of diabetes care and treatment of patients with type 2 diabetes (DM2), as the treatment and care of these patients take place in both primary care and specialist settings. The collaboration involves a large number of actors from primary and secondary healthcare sectors, who are expected to fulfil various roles when they engage in IC. We explored the actors' roles by applying the framework of positioning theory with the aim of revealing seemingly embedded understandings of such roles. The empirical data consisted of individual and focus group interviews. Our results indicate that naturalised understandings of the roles of actors interact with the way in which health professionals, patients, managers and relatives strive to develop IC that aims to help and guide patients who live with DM2.
Unusual presentation of disseminated cryptococcal infection complicated by myocarditis in a heart transplant recipient
Authors: Barros Kathryn , Tepper John William , Ramchandani Juhi , Kelley Meagan Kristine , Kussin Michelle L. , Israel Emily N. , Tompkins Madeline G. , Alali Muayad 
Published: July 2023

AbstractBackgroundCryptococcus neoformansis the third most common cause of invasive fungal infection in solid organ transplant (SOT) recipients. While cryptococcal infection can involve any organ, cases of myocarditis are exceedingly rare.MethodsA retrospective chart review was completed for this case report.ResultsWe present the case of a 21‐year‐old heart transplant recipient who developed disseminated cryptococcal infection with biopsy‐proven cryptococcal myocarditis.ConclusionsCryptococcal disease in SOT recipients poses diagnostic and therapeutic challenges. There are no current guidelines for the duration of cryptococcal myocarditis treatment. Repeat myocardial biopsy may play a role in guiding length of therapy.
Diversity of Colletotrichum species causing anthracnose on three oak species (Quercus acutissima, Q. mongolica and Q. variabilis) in China
Authors: Wang Cheng‐Bin , Li Yong , Xue Han , Piao Chun‐Gen , Jiang Ning 
Published: July 2023

AbstractAnthracnose of oak (Quercus) caused by Colletotrichum spp. is one of the most common diseases in oak forests. To investigate the species diversity of Colletotrichum associated with oak anthracnose, symptomatic leaf samples of three oak species (Q. acutissima, Q. mongolica and Q. variabilis) were collected from Anhui, Hainan, Henan, Shaanxi and Shandong Provinces, Inner Mongolia Autonomous Region, and Beijing City in China from 2019 to 2022. A total of 219 Colletotrichum isolates were obtained and identified by morphological and phylogenetic analyses of the rDNA internal transcribed spacer (ITS), glyceraldehyde‐3‐phosphate dehydrogenase (gapdh), chitin synthase 1 (chs‐1), actin (act) and β‐tubulin (tub2) sequences. Nine species were identified: C. fioriniae (two isolates, 0.9%), C. camellia‐japonicae (two isolates, 0.9%), C. karstii (three isolates, 1.4%), C. quercicola (two isolates, 0.9%), C. aenigma (three isolates, 1.4%), C. endophyticum (two isolates, 0.9%), C. fructicola (68 isolates, 31.1%), C. gloeosporioides sensu stricto (74 isolates, 33.8%) and C. siamense (63 isolates, 28.8%). Pathogenicity was confirmed using Koch's postulates, which showed that five species (C. camellia‐japonicae, C. endophyticum, C. fructicola, C. gloeosporioides s. s. and C. siamense) caused Q. acutissima anthracnose, four species (C. karstii, C. fructicola, C. gloeosporioides s. s. and C. siamense) caused Q. mongolica anthracnose and six species (C. fioriniae, C. quercicola, C. aenigma, C. fructicola, C. gloeosporioides s. s. and C. siamense) caused Q. variabilis anthracnose. This study demonstrates the pathogenic species diversity of Colletotrichum on Q. acutissima, Q. mongolica and Q. variabilis.
Complications following alveolar ridge augmentation procedures
Authors: Leblebicioglu Binnaz , Tatakis Dimitris N. 
Published: July 2023

AbstractOral rehabilitation through implant supported dental restorations often requires a ridge augmentation procedure (RAP) prior to implant fixture placement since tooth extraction/loss results in alveolar ridge deficiencies. Although RAP‐related surgical techniques and biomaterials have been in practice for several decades, outcomes are not always predictable. Post‐surgical complications experienced during the early or late wound healing phases may jeopardize the targeted ideal ridge dimensions, required for implant fixture placement, and may have other consequences, such as negatively impacting the patient's quality of life. This review describes reported post‐surgical complications following RAP under the following subtitles: complications by tissue type, complications in function and aesthetics, complications by healing time, complications by biomaterial type, and complications by surgical protocol modalities. Specifically, RAP performed by using particulate bone graft substitutes and related complications are explored. Modalities developed to prevent/manage these complications are also discussed.
Role of macrophage scavenger receptor 1 in the progression of dyslipidemia in acne vulgaris patients
Authors: AbdElneam Ahmed Ibrahim , Al‐Dhubaibi Mohammed Saleh , Bahaj Saleh Salem , Mohammed Ghada Farouk 
Published: July 2023

AbstractBackgroundMacrophage scavenger receptor 1 gene (MSR1), is responsible for producing macrophage scavenger receptors. MSR1 is primarily located on the surfaces of various macrophage types and is known to exert a range of effects on the human body. These effects include influencing innate and adaptive immunological reactions, as well as contributing to the development of conditions such as atherosclerosis, dyslipidemia, liver and lung disease, and cancer. The unregulated assimilation of lipoproteins by MSR1 leads to the creation of macrophages rich in cholesterol that manifest as foam‐like cells, ultimately contributing to dyslipidemia. This occurrence highlights the significance of MSR1 as a key player in the pathophysiology of dyslipidemia.AimIn this study, we aimed to estimate variation in lipid profile in acne vulgaris (AV) patients. Also, we aimed to investigate the role of MSR1 in lipid profile variation.Subjects and methodsA case‐control study consisting of 100 patients with AV and 104 healthy controls. Lipid profiles were assessed using normalized enzymatic processes and genotype analyses were performed by a polymerase chain reaction and standard Sanger sequencing. Predictions of variant effects were performed using in silico tools.ResultOur results indicated that the levels of lipid profile were higher in patients with AV than in healthy patients. The two haplotypes that were most prevalent in the patients were TCAC (16.5%) and CAGG (15.47%), whereas the two haplotypes that were more prevalent in the controls were TAAC (16.43%) and CCAC (15.62%). IVS5.59 C > A and rs433235 A > G are in linkage disequilibrium. Additionally, rs433235 A > G has a significant linkage disequilibrium with rs3747531 C > G. In silico analysis, tools indicated that the rs433235 A > G variant was disease‐causing.ConclusionPatients diagnosed with TCAC and CAGG exhibited a higher prevalence compared to healthy patients with TAAC and CCAC. The linkage disequilibrium between rs433235 A > G and IVS5.59 C > A has been established. Furthermore, there appears to be significant linkage disequilibrium between rs3747531 C > G and rs433235 A > G. These findings support the notion that genetic variations may play a critical role in the pathogenesis of these conditions.
Geomorphometry and microelectronic metrology: Converged realms
Authors: Dedkova A. A. , Florinsky I. V. 
Published: July 2023

AbstractThis article discusses the application of geomorphometric methods in microelectronic metrology. Six typical microelectronic items were geomorphometrically analyzed using their digital elevation models with nano‐ and micrometer‐range resolution and elevation difference: (1) a silicon–quartz structure; (2) a mechanically polished silicon wafer; (3) a photovoltaic blend sample; (4) an X‐ray optical element (a fused quartz spherical concave substrate); (5) a Bosch process‐formed, 20 aluminum layered membrane; and (6) a silicon–glass assembly with a volumetric defect. Geomorphometric modeling increases significantly the visibility and informativeness of data presentation, allowing to identify effectively the spatial distribution of nano‐ and microforms of the surface of microelectronic items. Geomorphometric methods provide an opportunity to study the size, location, and characteristic features of nano‐ and microtopographic inhomogeneities of microelectronic items using maps of minimum, maximum, mean, and unsphericity curvatures as well as other morphometric variables.
Organ donation following medical assistance in dying, Part II: a scoping review of existing processes and procedures
Authors: Silva e Silva Vanessa , Silva Amina Regina , Rochon Andrea , Lotherington Ken , Hornby Laura , Wind Tineke , Bollen Jan , Wilson Lindsay C. , Sarti Aimee J. , Dhanani Sonny 
Published: July 2023

Objective:
The objective of this review was to collate and summarize the current literature on what is known about organ donation following medical assistance in dying (MAiD). For this second part of a 2-part scoping review, the focus is on the existing procedures and processes for organ donation following MAiD.

Introduction:
Organ donation following MAiD is a novel and contentious issue worldwide. To give direction for future research and initiatives, a comprehensive understanding of the available evidence of existing procedures and processes for organ donation following MAiD is needed.

Inclusion criteria:
For this review, the population of interest included all individuals who underwent organ donation following MAiD; the concept was defined as procedures and processes involved in organ donation after MAiD; and the context was reports of organ donation following MAiD at home or in any health care setting worldwide. We considered quantitative and qualitative studies, text and opinion papers, gray literature, and unpublished material provided by stakeholders.

Methods:
This scoping review was conducted in line with JBI methodology. Published studies were retrieved from MEDLINE (Ovid), Embase (Ovid), CINAHL (EBSCOhost), PsycINFO (Ovid), Web of Science Core Collection, and Academic Search Complete (EBSCOhost). Gray and unpublished literature included reports from websites and organ donation organizations in Canada, Belgium, and The Netherlands. Two independent reviewers screened all reports (both title and abstract, and full text) against the predetermined inclusion criteria, extracted data, and completed a content analysis. Any disagreements between the 2 reviewers were resolved through discussion or with another reviewer.

Results:
We included 121 documents across parts I and II, and we report on 107 documents in this second part. The majority of the 107 documents were discussion papers, published in English, and in Canada from 2019 to 2021. In the content analysis, we identified 5 major categories regarding existing procedures and processes of organ donation following MAiD: i) clinical pathways for organ donation following MAiD; ii) organ donation following MAiD and the donor; iii) clinical practice tools for organ donation following MAiD; iv) education and support for health care providers involved in organ donation following MAiD; and v) health care providers’ roles and perceptions during organ donation following MAiD.

Conclusions:
Findings from this review can be used to provide support and guidance for improvements in procedures and processes, as well as a rich resource for countries currently planning to establish programs for organ donation after MAiD.
Breaking Mechanism and Performance of Coal Subjected to Water Jets Under High In Situ Stress
Authors: Zhang Di , Cao Shirong , Ge Zhaolong , Zhou Zhe , Liu Xiangjie 
Published: July 2023

AbstractThe effect of in situ stress on the coal-breaking characteristics of water jets remains unclear, prohibiting the deep coalbed methane (CBM) development. Water jet coal-breaking experiments under different mean three-dimensional (3D) stresses and horizontal stress differences were carried out with a self-developed in situ stress simulator. When the mean 3D stress increased, coal changed from shear and tensile failure to shear failure, and the volume of the erosion pit first decreased rapidly and then slowly. Upon increasing the mean 3D stress from 0 to 10 MPa, the volume of the erosion pit decreased by 79.7%, and the specific energy consumption increased nearly five times. With an increase in horizontal stress difference, coal transitioned from shear failure to shear and tensile failure, resulting in a shear crack farther from the erosion pit. At a horizontal stress difference of 15 MPa, the volume of the erosion pit and specific energy consumption had maximum and minimum values, respectively. Consequently, constructing a higher horizontal stress difference helps improve the coal-breaking efficiency of water jets. This study could lay the foundation for applying water jet technology in deep coal seams.
Static Characteristics of High-Speed Water-Lubricated Journal Bearing Considering Turbulence and Cavitation Effects
Authors: Zhang Hao , Lin Xiaohui , Jiang Shuyun 
Published: July 2023

Abstract
The water-lubricated bearings tend to be turbulent and cavitating when running at a high speed. However, the modeling of the water-lubricated bearing considering the turbulence and cavitation effects has not been studied thoroughly. For high-speed water-lubricated journal bearings, a turbulent flow model considering cavitation effect was proposed on the basis of two-phase flow theory. The simulation was conducted to show the influence of turbulence and cavitation effects on the static characteristics of the water-lubricated journal bearing. The proposed model was validated with the test by using a self-developed experimental setup. The result shows that the turbulence effect has a great impact on static characteristics of bearing, and cavitation effect significantly affects the minimum film thickness and leakage flowrate, while the friction torque is hardly affected by the cavitation effect.
Global analysis of putative phospholipases in
Plasmodium falciparum
reveals an essential role of the phosphoinositide-specific phospholipase C in parasite maturation
Authors: Burda Paul-Christian , Ramaprasad Abhinay , Bielfeld Sabrina , Pietsch Emma , Woitalla Anna , Söhnchen Christoph , Singh Mehar Nihal , Strauss Jan , Sait Aaron , Collinson Lucy M. , Schwudke Dominik , Blackman Michael J. , Gilberger Tim-Wolf 
Published: July 2023

ABSTRACT

For its replication within red blood cells, the malaria parasite depends on a highly active and regulated lipid metabolism. Enzymes involved in lipid metabolic processes such as phospholipases are, therefore, potential drug targets. Here, using reverse genetics approaches, we show that only 1 out of the 19 putative phospholipases expressed in asexual blood stages of
Plasmodium falciparum
is essential for proliferation
in vitro
, pointing toward a high level of redundancy among members of this enzyme family. Using conditional mislocalization and gene disruption techniques, we show that this essential phosphoinositide-specific phospholipase C (PI-PLC, PF3D7_1013500) has a previously unrecognized essential role during intracellular parasite maturation, long before its previously perceived role in parasite egress and invasion. Subsequent lipidomic analysis suggests that PI-PLC mediates cleavage of phosphatidylinositol bisphosphate (PIP
2
) in schizont-stage parasites, underlining its critical role in regulating phosphoinositide levels in the parasite.

IMPORTANCE

The clinical symptoms of malaria arise due to repeated rounds of replication of
Plasmodium
parasites within red blood cells (RBCs). Central to this is an intense period of membrane biogenesis. Generation of membranes not only requires
de novo
synthesis and acquisition but also the degradation of phospholipids, a function that is performed by phospholipases. In this study, we investigate the essentiality of the 19 putative phospholipase enzymes that the human malaria parasite
Plasmodium falciparum
expresses during its replication within RBCs. We not only show that a high level of functional redundancy exists among these enzymes but, at the same time, also identify an essential role for the phosphoinositide-specific phospholipase C in parasite development and cleavage of the phospholipid phosphatidylinositol bisphosphate.
Safety of BA.4-5 or BA.1 bivalent mRNA booster vaccines: nationwide cohort study
Authors: Andersson Niklas Worm , Thiesson Emilia Myrup , Hansen Jørgen Vinsløv , Hviid Anders 
Published: July 2023

Abstract

Objective
To examine the association between the omicron adapted bivalent mRNA covid-19 booster vaccines received as a fourth dose and risk of adverse events.

Design
Nationwide cohort study.

Setting
Denmark.

Participants
2 225 567 adults aged ≥50 years who received three covid-19 vaccine doses during the study period, 1 January 2021 to 10 December 2022.

Main outcome measures
The main outcome measure was rates of hospital visits for 27 different adverse events in a 28 day main risk period after vaccination with a bivalent omicron adapted mRNA booster vaccine as a fourth dose compared with reference period rates from day 29 after the third or fourth vaccine dose and onward.

Results

1 740 417 adults (mean age 67.8 years, standard deviation 10.7 years) received a bivalent mRNA vaccine as a fourth dose. Fourth dose vaccination with a bivalent mRNA vaccine was not associated with a statistically significant increased rate of any of the 27 adverse outcomes within 28 days (eg, incidence rate ratio of 0.95, 95% confidence interval of 0.87 to 1.04 for ischaemic cardiac events based on 672
v
9992 events during the compared 28 day risk and reference period, respectively), nor when analysed according to age, sex, or vaccine type, or when using alternative analytical approaches. However, post hoc analysis detected signals for myocarditis (statistically significant in female participants), although the outcome was rare and findings were based on few cases. No risk of cerebrovascular infarction was found (incidence rate ratio 0.95, 95% confidence interval 0.87 to 1.05; 644
v
9687 events).

Conclusions
The use of bivalent mRNA vaccines as a fourth vaccine dose against covid-19 was not associated with an increased risk of 27 different adverse events in adults aged ≥50 years.
Refreshing the emergency medicine research priorities
Authors: Cottey Laura , Shanahan Thomas Alexander Gerrard , Gronlund Toto , Whiting Caroline , Sokunbi Moses , Carley Simon David , Smith Jason E 
Published: July 2023

BackgroundThe priorities for UK emergency medicine research were defined in 2017 by a priority setting partnership coordinated by the Royal College of Emergency Medicine in collaboration with the James Lind Alliance (JLA). Much has changed in the last 5 years, not least a global infectious disease pandemic and a significant worsening of the crisis in the urgent and emergency care system. Our aim was to review and refresh the emergency medicine research priorities.MethodsA steering group including patients, carers and healthcare professionals was established to agree to the methodology of the refresh. An independent adviser from the JLA chaired the steering group. The scope was adult patients in the ED. New questions were invited via an open call using multiple communications methods ensuring that patients, carers and healthcare professionals had the opportunity to contribute. Questions underwent minisystematic (BestBETs) review to determine if the question had been answered, and the original 2017 priorities were reviewed. Any questions that remained unanswered were included in an interim prioritisation survey, which was distributed to patients, carers and healthcare professionals. Rankings from this survey were reviewed by the steering group and a shortlist of questions put forward to the final workshop, which was held to discuss and rank the research questions in order of priority.Results77 new questions were submitted, of which 58 underwent mini-systematic review. After this process, 49 questions (of which 32 were new, 11 were related to original priorities and 6 unanswered original priorities were carried forward) were reviewed by the steering group and included in an interim prioritisation survey. The interim prioritisation survey attracted 276 individual responses. 26 questions were shortlisted for discussion at the final prioritisation workshop, where the top 10 research priorities were agreed.ConclusionWe have redefined the priorities for emergency medicine research in the UK using robust and established methodology, which will inform the agenda for the coming years.
Effect of incomplete reperfusion patterns on clinical outcome: insights from the ESCAPE-NA1 trial
Authors: Cimflova Petra , Singh Nishita , Kappelhof Manon , Ospel Johanna M , Sehgal Arshia , Kashani Nima , Almekhlafi Mohammed A , Demchuk Andrew M , Berrouschot Joerg , Dorn Franziska , Kelly Michael E , Buck Brian H , Field Thalia S , Dowlatshahi Dariush , Tymianski Michael , Hill Michael D , Goyal Mayank 
Published: July 2023

BackgroundIncomplete reperfusion (IR) after mechanical thrombectomy (MT) can be a consequence of residual occlusion, no-reflow phenomenon, or collateral counterpressure. Data on the impact of these phenomena on clinical outcome are limited.MethodsPatients from the ESCAPE-NA1 trial with IR (expanded Thrombolysis In Cerebral Infarction (eTICI) 2b) were compared with those with complete or near-complete reperfusion (eTICI 2c-3) on the final angiography run. Final runs were assessed for (a) an MT-accessible occlusion, or (b) a non-MT-accessible occlusion pattern. The primary clinical outcome was modified Rankin Scale (mRS) 0–2 at 90 days. Our imaging outcome was infarction in IR territory on follow-up imaging. Unadjusted and adjusted incidence rate ratios (aIRR) with 95% confidence intervals (95% CI) were obtained.ResultsOf 1105 patients, 443 (40.1%) with IR and 506 (46.1%) with complete or near-complete reperfusion were included. An MT-accessible occlusion was identified in 147/443 patients (33.2%) and a non-MT-accessible occlusion in 296/443 (66.8%). As compared with patients with near-complete/complete reperfusion, patients with IR had significantly lower chances of achieving mRS 0–2 at 90 days (aIRR 0.82, 95% CI 0.74 to 0.91). Rates of mRS 0–2 were lower in the MT-accessible occlusion group as compared with the non-MT-accessible occlusion pattern group (aIRR 0.71, 95% CI 0.60 to 0.83, and aIRR 0.89, 95% CI 0.81 to 0.98, respectively). More patients with MT-accessible occlusion patterns developed infarcts in the non-reperfused territory as compared with patients with non-MT occlusion patterns (68.7% vs 46.3%).ConclusionIR was associated with worse clinical outcomes than near-complete/complete reperfusion. Two-thirds of our patients with IR had non-MT-accessible occlusion patterns which were associated with better clinical and imaging outcomes compared with those with MT-accessible occlusion patterns.