bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sheffield Shield Cricketers Live Longer than the Age-Matched General Australian Male Population
Authors: Luies Nathan , Orchard Jessica J. , Driscoll Tim , Sahdra Saaz Kaur , Cheng Jonathan , Davis Angus J. , Orchard John W. 
Published: September 2023

Abstract
Background/objectives
Previous studies have shown a trend that elite athletes tend to live longer than the general population, which has been attributed to the “healthy worker hire effect” and the health benefits of exercise. There have not been any previous studies looking at survival of elite cricketers with the general population as a reference cohort. This study aimed to compare the annual mortality rates of current and retired elite male Australian cricket players to that of the age-matched general Australian male population.

Methods
Analysis of publicly accessible dates of birth, death, and cricket debut data for male Australian Sheffield Shield cricket players who played before 2022 and had not died before 1971. Included persons were Sheffield Shield players who lived primarily in Australia during and after their cricket careers. Death rates from 1971 to 2021 (inclusive) were compared to the general Australian male population.

Results
1824 Sheffield Shield players had not died prior to 1971 (798 had played before the 1971 season, 1026 debuting subsequently). There were 586 deaths in the 51 years of observations, compared to 825 expected deaths, giving a Standardized Mortality Ratio of 0.71 (95% CI 0.63–0.80).

Conclusion
Elite Australian male Sheffield Shield cricket players outlive the general male population with lower death rates. This is probably due to a combination of the healthy worker hire effect and the health benefits of exercise. This study provides evidence that in terms of longevity, it is safe to play elite-level cricket in Australia.

Graphical Abstract
Ground penetrating radar in temperate ice: englacial water inclusions as limiting factor for data interpretation
Authors: Ogier Christophe , van Manen Dirk-Jan , Maurer Hansruedi , Räss Ludovic , Hertrich Marian , Bauder Andreas , Farinotti Daniel 
Published: September 2023

Abstract
Ground penetrating radar (GPR) has been extensively used in glaciology to infer glacier's ice thickness, liquid water content, water drainage pathways, and other properties. The interpretation of such GPR data is not always straightforward and for temperate glaciers, the signal is often affected by strong scattering and attenuation. It has often been suggested that such effects originate from englacial water inclusions, since water and ice have a large contrast in their di-electric permittivity. To investigate such effects quantitatively, we perform an extensive numerical modeling study of GPR signals. By exploring how different liquid water contents (LWC) and water-inclusions size affect the GPR signal, we show that their effects are much larger than the potential presence of a wet snowpack or a heterogeneous distribution of ice permittivity. In particularly, we show that the presence of such water inclusions is a necessary and sufficient condition for reproducing the typical characteristics of GPR data acquired in the field. Further, we find that for 25 MHz GPR antennas, a bulk LWC

$\gtrsim$

0.2%, associated with decimeters-scale water inclusions already limits bedrock detectability for ice thicknesses

$\gtrsim 100$

m. Since these values are typical for Alpine glaciers, they clarify why the quality of GPR data is often poor in such environments.
More than just ambivalence: the perception of emotionally ambiguous words on the spaces of origin and activation indexed by behavioural and webcam-based eye-tracking correlates
Authors: Wielgopolan Adrianna , Imbir Kamil K. 
Published: September 2023

AbstractWhen we think about emotional ambiguity, we usually think about the feeling of ambivalence. However, in a recently proposed model, ambiguity might also be present in different emotional spaces, such as origin (dimensions of automaticity and reflectiveness) and activation (arousal and subjective significance) as proposed in the basics of dual-process theories. In two experiments, we checked for behavioural and psychophysical differences in processing words of origin and activation ambiguities while completing an emotionality rating task. In Experiment 1, we assessed emotionality ratings and reaction times; in Experiment 2, we used a webcam-based eye-tracking measurement to assess the number and mean duration of fixations. We found significant effects for words differing in origin and activation: the emotionality ratings increased within the intensity of origin ambiguity but decreased within the intensity of activation ambiguity; more and longer fixations were registered for words of higher origin ambiguity; and gradually fewer and shorter fixations were registered within increases in activation ambiguity. We found that the ambiguities on spaces of origin and activation produced their own main effects, but they also factored significantly into the interaction, modifying each other’s results. Our study is the first to show specifics of the perception of ambiguous stimuli on spaces other than valence.
Effects of epicatechin on cardiovascular function in middle-aged diet-induced obese rat models of metabolic syndrome
Authors: Connolly Kylie , Batacan Romeo , Jackson Douglas , Fenning Andrew Stuart 
Published: September 2023

AbstractThe current study aimed to investigate the cardiovascular effects of epicatechin, a flavonoid found in green tea and cocoa, in attenuating complications associated with metabolic syndrome in diet-induced obese rats. Male Wistar-Kyoto (WKY) rats aged 16 weeks were fed either standard rat chow or given a high-fat-high-carbohydrate (HFHC) diet for 20 weeks. Epicatechin treatment (5 mg/kg/d) was administered to a subset of WKY rats commencing at week 8 of the 20 week HFHC feeding period. Body weights, food, water and energy intakes, blood pressure, heart rate and glucose tolerance were measured throughout the treatment period. Oxidative stress and inflammatory markers, lipid levels, cardiac collagen deposition, cardiac electrical function, aortic and mesenteric vessel reactivity were examined after the treatment. Twenty weeks of HFHC feeding in WKY rats resulted in the development of metabolic syndrome indicated by the presence of abdominal obesity, dyslipidaemia, glucose intolerance and increased blood pressure. Epicatechin treatment was found to enhance the oxidative stress status in HFHC groups through an increase in serum nitric oxide levels and a decrease in 8-isoprostane concentrations. Furthermore, WKY-HFHC rats displayed a decrease in IL-6 levels. The lipid profiles in HFHC groups showed improvement, with a decrease in LDL-cholesterol and TAG and an increase in HDL-cholesterol levels observed in WKY-HFHC rats. However, epicatechin was not effective in preventing weight gain, glucose intolerance or hypertension in HFHC fed rats. Overall, the results of this study suggest that epicatechin has the potential to improve the underlying mechanisms associated with metabolic syndrome in obese rats.
Development and evaluation of a predictive algorithm and telehealth intervention to reduce suicidal behavior among university students
Authors: Hasking Penelope A. , Robinson Kealagh , McEvoy Peter , Melvin Glenn , Bruffaerts Ronny , Boyes Mark E. , Auerbach Randy P. , Hendrie Delia , Nock Matthew K. , Preece David A. , Rees Clare , Kessler Ronald C. 
Published: September 2023

AbstractBackgroundSuicidal behaviors are prevalent among college students; however, students remain reluctant to seek support. We developed a predictive algorithm to identify students at risk of suicidal behavior and used telehealth to reduce subsequent risk.MethodsData come from several waves of a prospective cohort study (2016–2022) of college students (n = 5454). All first-year students were invited to participate as volunteers. (Response rates range: 16.00–19.93%). A stepped-care approach was implemented: (i) all students received a comprehensive list of services; (ii) those reporting past 12-month suicidal ideation were directed to a safety planning application; (iii) those identified as high risk of suicidal behavior by the algorithm or reporting 12-month suicide attempt were contacted via telephone within 24-h of survey completion. Intervention focused on support/safety-planning, and referral to services for this high-risk group.Results5454 students ranging in age from 17–36 (s.d. = 5.346) participated; 65% female. The algorithm identified 77% of students reporting subsequent suicidal behavior in the top 15% of predicted probabilities (Sensitivity = 26.26 [95% CI 17.93–36.07]; Specificity = 97.46 [95% CI 96.21–98.38], PPV = 53.06 [95% CI 40.16–65.56]; AUC range: 0.895 [95% CIs 0.872–0.917] to 0.966 [95% CIs 0.939–0.994]). High-risk students in the Intervention Cohort showed a 41.7% reduction in probability of suicidal behavior at 12-month follow-up compared to high-risk students in the Control Cohort.ConclusionsPredictive risk algorithms embedded into universal screening, coupled with telehealth intervention, offer significant potential as a suicide prevention approach for students.
Hospital-based health technology assessment of innovative medical devices: insights from a nationwide survey in France
Authors: Martin Tess , Guercio Alessandra , Besseau Hélène , Huot Laure , Guerre Pascale , Atfeh Jamal , Piazza Laurent , Pineau Judith , Sabatier Brigitte , Borget Isabelle , Martelli Nicolas 
Published: September 2023

Abstract

Objectives
To better understand the process of hospital acquisition of innovative medical devices (MDs) and the hospital-based health technology assessment (HB-HTA) pathways in France, an in-depth study based on a quantitative approach is needed. The aim of the present study was to assess through a national survey how HB-HTA is currently implemented in French hospitals and to identify its level of formalization.

Methods
A quantitative online survey was conducted among hospitals performing HB-HTA in France, with a focus on the acquisition of innovative MDs for individual use. The survey, conducted between March and June 2022, was developed by a scientific board composed of members of the French-speaking Society for HB-HTA.

Results
Sixty-seven out of 131 surveyed hospitals with HB-HTA activities responded, including 29 university hospitals, 24 nonprofit private hospitals, and 14 local hospitals. Sixty-one respondents (91 percent) reported the existence of a process dedicated to evaluating innovative MDs; of these, 16 declared that their hospitals had a formalized unit with HB-HTA activity. These units were more frequently found in larger hospitals with more than 500 inpatient beds (n = 16, p = 0.0160) and in university hospitals (n = 12, p = 0.0158). No hospital reported any collaboration with HAS, the French national HTA agency.

Conclusion
A diverse range of HB-HTA organizations with different structural levels exist in France for MD procurement linked to the category of hospitals. The study highlights the need for recognition of HB-HTA activity at the regulatory level in France and for direct collaboration between HTA activities performed at local and national levels.
Socio-environmental responsibility in Iranian universities: a multidimensional perspective
Authors: Kolahi Mahdi , AzimiSeginSara Rogaieh 
Published: September 2023

SummaryUniversities are expected to play a pivotal role in promoting environmental conservation goals, yet a comprehensive analysis of their actual contributions remains limited. This study delves into the perceptions of socio-environmental responsibility among faculty members within Iran’s top 13 universities. Using random cluster sampling, we collected 410 questionnaires from these institutions, evaluating socio-environmental responsibility through eight distinct variables. The outcomes unveil widespread deficiencies in responsibility across all universities, with 66% exhibiting low levels of engagement. Notably, Gorgan University of Agricultural Sciences and Natural Resources displays the lowest level, while Bu-Ali Sina University ranks highest. The research variables exhibit significant positive correlations, elucidating the interconnectedness of different aspects of socio-environmental responsibility. Furthermore, the study identifies a significant disparity in mean university socio-environmental responsibility concerning gender, although no significant relationships are found with factors such as professors’ academic rank, employment status or age. Sixteen codes are highlighted based on qualitative analysis. These findings underscore the urgency for universities to redefine their roles within the community and prioritize community empowerment, stakeholder engagement, capacity building and environmental education. By addressing these facets, universities can elevate their levels of socio-environmental responsibility and contribute more effectively to environmental conservation efforts.
Rising Coastal Groundwater as a Result of Sea‐Level Rise Will Influence Contaminated Coastal Sites and Underground Infrastructure
Authors: Hill K. , Hirschfeld D. , Lindquist C. , Cook F. , Warner S. 
Published: September 2023

AbstractSea‐level rise (SLR) will cause coastal groundwater to rise in many coastal urban environments. Inundation of contaminated soils by groundwater rise (GWR) will alter the physical, biological, and geochemical conditions that influence the fate and transport of existing contaminants. These transformed products can be more toxic and/or more mobile under future conditions driven by SLR and GWR. We reviewed the vulnerability of contaminated sites to GWR in a US national database and in a case comparison with the San Francisco Bay region to estimate the risk of rising groundwater to human and ecosystem health. The results show that 326 sites in the US Superfund program may be vulnerable to changes in groundwater depth or flow direction as a result of SLR, representing 18.1 million hectares of contaminated land. In the San Francisco Bay Area, we found that GWR is predicted to impact twice as much land area as inundation from SLR, and 5,282 additional state‐managed sites of contamination may be vulnerable to inundation from GWR in a 1.0 m SLR scenario. Increases of only a few centimeters of elevation can mobilize soil contaminants, alter flow directions in a heterogeneous urban environment with underground pipes and utility trenches, and result in new exposure pathways. Pumping for flood protection will elevate the saltwater interface, changing groundwater salinity and mobilizing metals in soil. Socially vulnerable communities are disproportionately exposed to this risk at both the national scale and in a regional comparison with the San Francisco Bay Area.
Impact of Giant Iceberg A68A on the Physical Conditions of the Surface South Atlantic, Derived Using Remote Sensing
Authors: Smith R. M. , Bigg G. R. 
Published: September 2023

AbstractGiant icebergs release cold, fresh meltwater as they drift, perturbing the physical conditions of the surface ocean. This study uses satellite‐derived sea surface salinity and temperature measurements to explore the physical impact of supergiant iceberg A68A between September 2020 and June 2021. During A68A's drift through the Scotia Sea in austral spring, gradual but persistent edge‐wasting contributed to a freshening of several psu extending hundreds of kilometers ahead of the iceberg, whilst the cooling signal was more pronounced in the iceberg's wake. The magnitude of the physical perturbation intensified during A68A's breakup near South Georgia. Several large meltwater lenses surrounding the descendant icebergs displayed temperature anomalies of up to −4.5°C, whilst the salinity measurements indicated a surface (skin‐depth) anomaly regularly exceeding order −10 psu. The perturbations stretched at times >1,000 km and persisted for >2 months following A68A's melt in April 2021.
Quantitative Analysis of Paleomagnetic Sampling Strategies
Authors: Sapienza F. , Gallo L. C. , Zhang Y. , Vaes B. , Domeier M. , Swanson‐Hysell N. L. 
Published: September 2023

AbstractSampling strategies used in paleomagnetic studies play a crucial role in dictating the accuracy of our estimates of properties of the ancient geomagnetic field. However, there has been little quantitative analysis of optimal paleomagnetic sampling strategies and the community has instead defaulted to traditional practices that vary between laboratories. In this paper, we quantitatively evaluate the accuracy of alternative paleomagnetic sampling strategies through numerical experiments and an associated analytical framework. Our findings demonstrate a strong correspondence between the accuracy of an estimated paleopole position and the number of sites or independent readings of the time‐varying paleomagnetic field, whereas larger numbers of in‐site samples have a dwindling effect. This remains true even when a large proportion of the sample directions are spurious. This approach can be readily achieved in sedimentary sequences by distributing samples stratigraphically, considering each sample as an individual site. However, where the number of potential independent sites is inherently limited the collection of additional in‐site samples can improve the accuracy of the paleopole estimate (although with diminishing returns with increasing samples per site). Where an estimate of the magnitude of paleosecular variation is sought, multiple in‐site samples should be taken, but the optimal number is dependent on the expected fraction of outliers. The use of filters based on angular distance helps the accuracy of paleopole estimation, but leads to inaccurate estimates of paleosecular variation. We provide both analytical formulas and a series of interactive Jupyter notebooks allowing optimal sampling strategies to be developed from user‐informed expectations.
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation
Authors: Ouyang Weijie , Wang Shoubi , Yan Dan , Wu Jieli , Zhang Yunuo , Li Wei , Hu Jiaoyue , Liu Zuguo 
Published: September 2023

AbstractThe innate immune response is the main pathophysiological process of ocular surface diseases exposed to multiple environmental stresses. The epithelium is central to the innate immune response, but whether and how innate immunity is initiated by ocular epithelial cells in response to various environmental stresses in ocular surface diseases, such as dry eye, is still unclear. By utilizing two classic experimental dry eye models—a mouse ocular surface treated with benzalkonium chloride (BAC) and a mouse model with surgically removed extraorbital lachrymal glands, as well as dry eye patient samples—along with human corneal epithelial cells (HCE) exposed to hyperosmolarity, we have discovered a novel innate immune pathway in ocular surface epithelial cells. Under stress, mitochondrial DNA (mtDNA) was released into the cytoplasm through the mitochondrial permeability transition pore (mPTP) and further activated the cyclic GMP-AMP synthase (cGAS)—stimulator of interferon genes (STING) pathway, aggravating downstream inflammatory responses and ocular surface damage. Genetic deletion or pharmacological suppression of STING and inhibition of mtDNA release reduced inflammatory responses, whereas mtDNA transfection supported cytoplasmic mtDNA-induced inflammatory responses by activating the cGAS-STING pathway. Our study clarified the cGAS-STING pathway-dependent sensing of mitochondrial DNA-mediated ocular surface inflammation, which elucidated a new mechanism of ocular surface diseases in response to multiple environmental stresses.
Hepatic T-cell senescence and exhaustion are implicated in the progression of fatty liver disease in patients with type 2 diabetes and mouse model with nonalcoholic steatohepatitis
Authors: Sim Byeong Chang , Kang Yea Eun , You Sun Kyoung , Lee Seong Eun , Nga Ha Thi , Lee Ho Yeop , Nguyen Thi Linh , Moon Ji Sun , Tian Jingwen , Jang Hyo Ju , Lee Jeong Eun , Yi Hyon-Seung 
Published: September 2023

AbstractImmunosenescence and exhaustion are involved in the development and progression of type 2 diabetes (T2D) and metabolic liver diseases, including fatty liver, fibrosis, and cirrhosis, in humans. However, the relationships of the senescence and exhaustion of T cells with insulin resistance-associated liver diseases remain incompletely understood. To better define the relationship of T2D with nonalcoholic fatty liver disease, 59 patients (mean age 58.7 ± 11.0 years; 47.5% male) with T2D were studied. To characterize their systemic immunophenotypes, peripheral blood mononuclear cells were analyzed using flow cytometry. Magnetic resonance imaging (MRI)-based proton density fat fraction and MRI-based elastography were performed using an open-bore, vertical-field 3.0 T scanner to quantify liver fat and fibrosis, respectively. The participants with insulin resistance had a significantly larger population of CD28 − CD57+ senescent T cells among the CD4+ and CD8 + T cells than those with lower Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) values. The abundances of senescent CD4+ and CD8 + T cells and the HOMA-IR positively correlated with the severity of liver fibrosis, assessed using MRI-based elastography. Interleukin 15 from hepatic monocytes was found to be an inducer of bystander activation of T cells, which is associated with progression of liver disease in the participants with T2D. Furthermore, high expression of genes related to senescence and exhaustion was identified in CD4+ and CD8 + T cells from the participants with nonalcoholic steatohepatitis or liver cirrhosis. Finally, we have also demonstrated that hepatic T-cell senescence and exhaustion are induced in a diet or chemical-induced mouse model with nonalcoholic steatohepatitis. In conclusion, we have shown that T-cell senescence is associated with insulin resistance and metabolic liver disease in patients with T2D.