bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction and Validation of a Coagulation Factor-Related Prognostic Model for Colorectal Cancer Based on the Public Database
Authors: Xu Hong-kai , Han Shao-liang , Lu Hao-feng , Dai Rui-shuai , Han Sai-yi , Xie Wei-dong 
Published: January 2023

Abstract
Background:Colorectal cancer is one of the most common malignant cancers in the world, which is a serious threat to human health with increasingly diagnosed cases every year.It has been reported that coagulation factors play an important role in various cancer. However, the role of coagulation factor-related genes in colorectal cancer remains unknown.
Methods: Gene expression data with clinical information of colorectal cancer samples were downloaded from the TCGA (The Cancer Genome Atlas) database and Gene Expression Omnibus (GEO) database, respectively. The coagulation factor-related prognostic model was constructed based on univariate, LASSO, and multivariate Cox regression analysis. In addition, colorectal cancer patients were classified into different subtypes according to non-negative matrix factorization (NMF) analysis. The nomogram and calibration curves were plotted to validate the accuracy of the coagulation factor-related prognostic model.Finally, the proportion of the infiltrating immune cells in different risk groups was analyzed by using immune cell infiltration
Results: Seven coagulation factor-related genes were screened out to establish a prognostic model. The risk score of each colorectal cancer sample was calculated by the product of each prognostic coagulation factor-related gene with prognostic value and the corresponding gene expression of each prognostic coagulation factor-related gene. Patients with colorectal cancer were classified into high- and low-risk groups according to the median risk score. Survival curves indicated that colorectal cancer patients in the high-risk group had a worse prognosis both in the training set, internal validation set, and external validation set. Colorectal cancer patients were divided into three subtypes (subtype C1, subtype C2, and subtype C3) according to the optimal number of clusters. The nomogram we established was accurate to predict the overall survival of colorectal cancer patients. The Sankey plot suggested that colorectal cancer patients in the subtype C2 and low-risk group had a better prognosis. Finally, immune cell infiltration analysis indicated that macrophages might play an important role in the development of colorectal cancer.
Conclusion: The coagulation factor-related prognostic model was established based on STIM1, PLCB1, MAPK12, F2RL2, C8G, C9, and ADCY5. The colorectal cancer patients were divided into three subtypes, including subtype C1, subtype C2, and subtype C3. These findings might provide novel therapeutic strategies for the treatment of patients with colorectal cancer.
Regional variations in distribution, diagnosis and treatment of chronic pancreatitis in the mainland China: a systematic review of case articles over 40 years
Authors: Wang Wei , Jiang Weisong , Shu Meng , Luo Liying , Liu Ao , Pan Xunke , Liu Jingjing , Wang Chong , Cao Yizhi , Wu TungChing , Liu Pengyi , Xv Junyao , Zhou Yiran 
Published: January 2023

Abstract
BACKGROUND: Epidemiological data regarding the regional differences in chronic pancreatitis (CP) from the mainland of China is lacking. We aimed to gather and combine the information concerning the regional distribution and the risk factors associated with pancreatic cancer (PaCa) and death from published articles.
METHODSː:Case articles on CP published in seven databases from January 1979 to December 2018 were analysed.
RESULTS: A total of 4,452 cases articles (containing 161,243 CP cases) were included. Since the mid-1990s, the number of published articles grew rapidly, which was significantly related to the gross domestic product of the region. In recent years, the number of CP cases of idiopathic etiology, those receiving endoscopic treatment, those with comorbid diabetes mellitus and the number of Science Citation Index (SCI) case articles have increased. Surgical treatment (37.4%) was closely associated to alcoholic CP (r = 0.55, P = 0.000), idiopathic CP (r = 0.52, P = 0.000), wasting (r = 0.21, P = 0.000), jaundice (r = 0.27, P = 0.000), PaCa and death detected during hospitalization and follow-up, and was more common in underdeveloped areas. Endoscopic therapy (27.9%) was mainly concentrated in developed areas, associated with non-alcoholic CP and a higher incidence of death (r = 0.48, P = 0.000) and PaCa (r = 0.3, P = 0.000) during follow-up. The total number of PaCa in CP cases was significantly related to the number of PaCa cases in each region (r = 0.94, P = 0.002). PaCa detected during hospitalization was mainly related to jaundice, pain, diabetes, biliary diseases, alcoholic CP, conservative treatment and surgical treatment.
CONCLUSIONS: The distribution of clinical features and management treasures showed obvious regional characteristics, which closely related to the local detection level of CP and PaCa, showing that there were likely to be many cases of misdiagnosis or delayed diagnosis of CP and PaCa. The problem of uneven distribution of medical resources, which related to the imbalance of economic and social development, needs to be resolved.
Bromocriptine for Central Hyperthermia after Acute Brain Injury: A Retrospective Cohort Study
Authors: Amin Suneri , Aghajan Yasmin , Webb Andrew 
Published: January 2023

Abstract
Introduction

Bromocriptine is a dopamine receptor agonist used in clinical practice for central hyperthermia with limited published data. We sought to describe the patient population treated with bromocriptine for central hyperthermia and report the most common dosing regimens, efficacy, and reasons for discontinuation of therapy.

Methods

This was a retrospective cohort study conducted at a single academic Level 1 Trauma Center and advanced comprehensive stroke center. Patients were 18 years and older, admitted to the neurocritical or surgical/trauma intensive care units for acute neurological emergencies, and were administered bromocriptine to manage central fevers between April 2016 and September 2022. Baseline characteristics, disease severity markers, and bromocriptine doses during ICU admission were collected. The highest body temperature in the 8 hours prior to the first dose of bromocriptine as well as at the time of dose and every hour for up to 6 hours after each dose were recorded. Hyperthermia was defined as a recorded temperature of ≥ 38.3°C. Potential bromocriptine responsiveness was defined as resolution of hyperthermia at 1- or 2-hours post-bromocriptine administration. Coadministration of additional therapies for fever management or paroxysmal sympathetic hyperactivity (PSH) and confounding therapies were noted.

Results

30 patients were included with a mean age of 45 (± 17.3) years. Patients were 70% male and 67% Caucasian. The most common diagnosis was TBI (N = 14) followed by SAH (N = 6), and median admission GCS was 5.5 (IQR 3.0-10.8). Median cumulative daily dose was 8mg (IQR 5–15, range 2.5–60). There was a paired mean difference of -0.37°C (p = 0.005) between the average temperature prior to bromocriptine initiation and after initiation. Potential responsiveness was observed after 41% of doses at 1 hour and 62% of doses at 2 hours. All patients received at least one other therapy for management of fevers or PSH and at least one potentially confounding therapy. The most common reason for discontinuation was resolution of indication (N = 14). Discontinuation due to mild adverse effects occurred in 4 patients.

Conclusion

Bromocriptine is a potential therapy for management of central hyperthermia in patients with acute neurologic emergencies for severely critically ill patients who have failed other therapies. There was a small but statistically significant decrease in average temperature pre- and post-administration of bromocriptine. Results may have been confounded by administration of additional medications and other antipyretics.
Dna Barcoding: Efficiency of Rbcl Gene for Sequence Characterisation of Cyperus Esculentus in Nigeria
Authors: Bello Ridwan Opeyemi , Ojokoh Anthony Okhonlaye , Babalola Deborah , Shonde. Temitope Esther , Towobola Funmilayo Mary 
Published: January 2023

AbstractBackground Plants have been classified based on morphological traits. However, there are biases associated with this classification. The limitation can be prevented by using DNA barcoding. Therefore, the efficiency of the Ribulose -bisphosphate carboxylase (rbcL) marker was investigated to identify Tiger Nut (Cyperus esculentus), which belongs to the family of Cyperaceae. In this study,C. esculentussamples were collected from two villages in northern Nigeria. For DNA barcoding, the rbcL region ofC. esculentussamples were amplified, sequenced in both directions, and subsequently analysed. The amplified sequences' biological sequence homology, sequence divergence, and phylogenetic tree construction were studied using Basic Local Alignment Tool (BLAST), Codon Code Aligner and MEGA X respectively. Results A 100% identity of rbcL locus with several other Cyperus species was obtained from BLAST result. The region seems highly conserved among several Cyperus species as variation within this marker locus’s sequence is minimal. However, a G/T variation at a nucleotide position could differentiate the tested samples from 40% of the other data bank species. The phylogenetic tree analysis clustered the 20 samples and the retrieved sequences based on the very few sequence variations without distinctly separatingC. esculentussamples from other Cyperus species. Conclusions These findings showed that rbcL marker could only identify our samples up to genius level. Therefore, other DNA barcoding markers are needed to identify and characteriseC. esculentussince the characterization based on rbcL gene sequences conducted in this work could not identifyC. esculentusup to the species level.
A rare case of anterior segment injury by bamboo filaments
Authors: Luo Li , Li Jun , Zhu Yanxia , Wu Jing , Zhang Min , HU Xin 
Published: January 2023

Abstract
Background: To report an unusual case of bamboo filaments sticking into the cornea, conjunctiva, and even penetrating the cornea into the anterior chamber.
Case presentation: A 53-year-old man injured his left eye accidentally with rotted bamboo filaments when cutting wood. After 2 weeks, he went to our hospital. We found there were many bamboo filaments embedded, not only in the subepithelial region of the cornea but also in the conjunctiva and anterior chamber. Superficial and subconjunctival foreign bodies were removed, and the deep corneal stroma and anterior chamber bamboo foreign bodies were observed statically. The patient was re-examined 1 week and 1 month after discharge and the results showed no significant inflammatory reaction to the residual foreign body. A long-term follow-up of this patient is still in process with further studies to be done.
Conclusion: Our current short-term follow-up observations suggest that, in contrast to the conjunctival reaction, bamboo filaments may pierce and lodge in the anterior chamber and cornea without significant inflammation.
Nonlinear Rayleigh wave propagation in a layered half-space in dual-phase-lag
Authors: Youssef A. A. , Amein N. K. , Abdelrahman N. S. , Abou-Dina M. S. , Ghaleb A. F. 
Published: January 2023

Abstract
We investigate nonlinear Rayleigh wave propagation in a layered thermoelastic medium composed of a slab rigidly bonded to the surface of a half-space under prescribed external thermal boundary conditions within the dual-phase-lag theory. The heat conduction coecient for both the slab and the matrix have a linear dependence on temperature. Our aim is to assess the eect of temperature dependence of the heat conductivity, as well as the thermal relaxation times, on the process of wave propagation in the layered medium. Poincaré expansion of the solution in a small parameter and the generation of higher harmonics allow to evaluate the coecient of this nonlinear coupling in the slab through heat wave propagation measurement. For the used numerical values, the results show that some characteristics of the problem, e.g. the temperature, heat flux and one stress component suer jumps at the interface, while the other stress components are continuous there. The existence of jumps at the interface may be of interest for measurements. Comparison with the case of the half-space showed that the presence of the slab contributes to faster damping of the solution with depth in the half-space.
Influence of inflow directions and setting angle of inlet guide vane on hydraulic performance of an axial-flow pump
Authors: Nguyen Duc Anh , Ma Sang-Bum , Kim Sung , Kim Jin-Hyuk 
Published: January 2023

Abstract
Inlet flow direction significantly affects the hydraulic performance of an axial-flow pump. Usually, the research papers ignore this phenomenon, resulting in discrepancies between simulation and experimental results. This study examines the influence of inflow direction in five cases (0%, 5%, 10%, 15%, and 30% pre-swirl intensities) to determine the relationship between the pre-swirl intensity and the hydraulic performance of the axial-flow pump. Based on this, changing the setting angle of the inlet guide vane (IGV) is proposed and thoroughly investigated to reduce the effect of inflow direction. In this study, the influence of clearances in IGV blades on hydraulic performance is also investigated in detail. Numerical simulations are performed using ANSYS–CFX and a shear stress transport reattachment modification (SST k-) turbulence model with small y+ values at all walls. Specifically, the hydraulic performance curves and internal flow characteristics, including contours and streamlines, are assessed and analyzed. The inflow direction significantly impacts the hydraulic efficiency of the axial-flow pump. Increased pre-swirl intensity causes more loss in the IGV passage. The internal flow field and performance are not affected by the clearance at the hub and shroud of the IGV. However, the tip clearance of the impeller causes a decrease in hydraulic efficiency due to the tip leakage vortex. By adjusting the setting angle of the IGV, the efficiency and head gradually increase from a negative to a positive setting angle. Additionally, 30° is considered the critical setting angle for IGV.
A challenging and rare ablation of both epicardial and endocardial accessory pathway in a patient with paroxysmal supraventricular tachycardia
Authors: Bao Zhengyu , Zhu Ye , You Jia 
Published: January 2023

Abstract
Background:The standard approach for treating patients with paroxysmal supraventricular tachycardia(PSVT) is radiofrequency ablation. In patients with PSVT difffculty in ablation of accessory pathways(APs) is associated with failures and recurrences. Existence of epicardial and endocardial AP is a special case resulting in difffculties in radiofrequency ablation.
Case presentation: A 54-year-old female had a symptom of recurrent palpitation for 40 years. The electrocardiogram(ECG) showed supraventricular tachycardia. As the tachycardic episodes had been poorly controlled with conservative treatment, the patient underwent radiofrequency ablation. Invasive electrophysiology study performed and confirmed that the rare occurrence of both endocardial and epicardial AP in this case. The accessory pathways were epicardial AP of mitral valve annulus and endocardial AP of tricuspid annulus and mitral annulus posterior septum. Both epicardial and endocardial AP in one case was rare, however, ablation of this challenging and rare case is successful.The patient's ECG was normal after operation.. During the follow-up, the patient has had no recurrent tachycardia.
Conclusions: This rare and challenging case offers evidence for viable technique of epicardial ablation when conventional endocardial ablation process fail to block the AP conduction. As in this case, repeat strategy of electrophysiological study and precise mapping by an experienced operator should be a prerequisite to attempt ablation treatment.
Effects of different factors on the friction and wear mechanical properties of titanium alloy materials with cortical bones at near service conditions
Authors: Xingdong Sun , Jianfei Zhou , Wandi Wu , Renbo Zhang , Liangyuan Xu , Chengmao Cao , Rui Jiang , Liangfei Fang 
Published: January 2023

Abstract
Artificial joint is one of the most effective methods to treat joint injuries. The service performance of artificial joints is gradually bad due to the wear of artificial joints in actual service. In order to obtain the potential failure mechanism of the artificial joint in actual service, the study started with the multiple factors that affect the service performance of the artificial joint. The experimental study was carried out on the change rule of mechanical behavior of the contact interface between the artificial joint of titanium alloy and cortical bone. The multifactor of the research is compression load, contact load, friction velocity and lubrication environment. The results indicate that the friction coefficient, wear mass and wear coefficient of Ti-6A1-4V titanium alloy decrease with the increase of compression load. The friction rate and the friction coefficient of Ti-6A1-4V titanium alloy are decreasing with the increase of contact load. The wear mass and friction coefficient of Ti-6A1-4V titanium alloy increase with the increase of contact load. The friction coefficient, wear mass and wear coefficient of the wet friction test with the lubricant of bovine serum albumin are lower than those of the dry friction test. The lubrication effect is better as the increase of lubricant concentration. Based on the observation of the electron microscope, The wear type influenced by compression load is mainly abrasive wear and oxidation wear. The wear type influenced by compression load is mainly abrasive wear and oxidation wear. The wear type influenced by friction rate is mainly abrasive wear and oxidation wear. The wear type influenced by lubricants is mainly oxidation wear. When wear mass and wear coefficient are used as the criteria for evaluating friction and wear, the order of influential factors to friction and wear of Ti-6Al-4V titanium alloy plate is friction rate> compression load >contact load>lubricant concentration. The research result can provide a theoretical reference for the optimal manufacture of the artificial joint of titanium alloy and optimal rules of safe service conditions.
Impaired body image and physical and sexual limitations after surgical therapy for vulvar cancer: a qualitative study
Authors: Dongen Jessy van , Vincent Noor J.B. , de Munnik Suzanne , Ezendam Nicole P.M. , Esch Edith M.G. van , Boll Dorry 
Published: January 2023

Abstract
Purpose
Surgical treatment for vulvar cancer has impact on women’s self-esteem, body image and sexuality. Health Care Professionals experience difficulties in discussing these issues with patients. The aim of this study was to explore the experiences of patients with vulvar cancer regarding sexual changes, and their needs and expectations regarding sexual counseling.
Methods
Individual semi-structured interviews were conducted with patients who were surgically treated for vulvar cancer. All interviews were transcribed verbatim and thematically analyzed.
Results
Seven patients (mean age 54, 86% stage 1B vulvar cancer) participated. Seven themes were identified and were linked to the biopsychosocial framework: 1) the impact of physical disabilities on body image, 2) sexual dysfunction, 3) grieving the loss of sexual health, 4) ambivalence in the acceptance of sexual changes, 5) the effect of the partner on sexual experience, 6) the attitude of the Health Care Professional (HCP), and 7) discussing sexuality: the right moment
Conclusion
Patients who are surgically treated for vulvar cancer experience problems related to impairment on daily activities, altered body image and sexuality. Especially difficulties in reaching an orgasm or anorgasmia are hard to accept. Both the partner and HCP play an important role in how patients experience discussing and exploring sexuality after treatment. Since informational needs regarding sexuality change over time and patients start to fantasize about sex after 4–6 months, it is recommended to schedule an appointment 4–6 months after surgery to discuss patients’ needs regarding sexual information and counseling.
Myocardial Perfusion SPECT in Germany from 2012 to 2021:
Insights into Development and Quality Indicators
Authors: Lindner Oliver , Schäfer Wolfgang , Rischpler Christoph , Silber Sigmund , Burchert Wolfgang 
Published: January 2023

Abstract
Purpose: This paper summarises the results of 4 national surveys on the numbers, utilisation and technique of myocardial perfusion SPECT (MPS) from 2012 to 2021.
Methods: A one-page questionnaire for information on MPS in 2012, 2015, 2018 and 2021 was sent to German centres practising nuclear medicine. To check for representativeness, the numbers obtained were related to official annual data and furthermore to the numbers of invasive coronary angiography procedures (ICA).
Results: MPS examinations increased by > 40% from 2012 to 2021 and showed a centralisation with increasing MPS per centre. In 2020, a mild impact of the Covid-19 pandemia could be observed in the form of only a slight MPS increase, which was compensated in the following year. Outpatient care cardiologists represent the most important referrer (70%).
Mostly, 2-day protocols were used. One-day protocols and stress-only protocols showed insignificant changes.
The use of exercise stress decreased steadily. In 2021, exercise stress was replaced by pharmacological stress as the most frequent stress modality.
Camera systems showed a shift to more SPECT-CT systems. The use of gated SPECT increased to almost 90%. Quantitative scoring showed an increasing acceptance.
The ratio of invasive coronary angiographies (ICA) to MPS was between 3.9 and 4.5. A significant proportion of ICA in the context of CCS was performed without prior testing for ischaemia.
Conclusion: The 2012 to 2021 MPS surveys reveal a continuously growing number of examinations with only a mild temporary effect of the Covid-19 pandemia and a centralisation with increasing numbers per centre. Performance and technical data reveal a high-grade adherence of MPS practice to the current ESC guideline. A large potential of non-invasive diagnostics remains for the future.