bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constraining quenching time-scales in galaxy clusters by forward-modelling stellar ages and quiescent fractions in projected phase space
Authors: Reeves Andrew M M , Hudson Michael J , Oman Kyle A 
Published: April 2023

ABSTRACT
We forward-model mass-weighted stellar ages (MWAs) and quiescent fractions (fQ) in projected phase space (PPS), using data from the Sloan Digital Sky Survey, to jointly constrain an infall quenching model for galaxies in log (Mvir/M⊙) &gt; 14 galaxy clusters at z ∼ 0. We find the average deviation in MWA from the MWA–M⋆ relation depends on position in PPS, with a maximum difference between the inner cluster and infalling interloper galaxies of ∼1 Gyr. Our model employs infall information from N-body simulations and stochastic star-formation histories from the universemachine model. We find total quenching times of tQ = 3.7 ± 0.4 Gyr and tQ = 4.0 ± 0.2 Gyr after first pericentre, for 9 &lt; log (M⋆/M⊙) &lt; 10 and 10 &lt; log (M⋆/M⊙) &lt; 10.5 galaxies, respectively. By using MWAs, we break the degeneracy in time of quenching onset and time-scale of star formation rate (SFR) decline. We find that time of quenching onset relative to pericentre is $t_{\mathrm{delay}}=3.5^{+0.6}_{-0.9}$ Gyr and $t_{\mathrm{delay}}=-0.3^{+0.8}_{-1.0}$ Gyr for 9 &lt; log (M⋆/M⊙) &lt; 10 and 10 &lt; log (M⋆/M⊙) &lt; 10.5 galaxies, respectively, and exponential SFR suppression time-scales are τenv ≤ 1.0 Gyr for 9 &lt; log (M⋆/M⊙) &lt; 10 galaxies and τenv ∼ 2.3 Gyr for 10 &lt; log (M⋆/M⊙) &lt; 10.5 galaxies. Stochastic star formation histories remove the need for rapid infall quenching to maintain the bimodality in the SFR of cluster galaxies; the depth of the green valley prefers quenching onsets close to first pericentre and a longer quenching envelope, in slight tension with the MWA-driven results. Taken together these results suggest that quenching begins close to, or just after pericentre, but the time-scale for quenching to be fully complete is much longer and therefore ram-pressure stripping is not complete on first pericentric passage.
Formation of proto-globular cluster candidates in cosmological simulations of dwarf galaxies at z &gt; 4
Authors: Sameie Omid , Boylan-Kolchin Michael , Hopkins Philip F , Wetzel Andrew , Ma Xiangcheng , Bullock James S , El-Badry Kareem , Quataert Eliot , Samuel Jenna , Schauer Anna T P , Weisz Daniel R 
Published: April 2023

ABSTRACT
We perform cosmological hydrodynamical simulations to study the formation of proto-globular cluster candidates in progenitors of present-day dwarf galaxies $(M_{\rm vir} \approx 10^{10}\, {\rm M}_\odot$ at z = 0) as part of the ‘Feedback in Realistic Environment’ (FIRE) project. Compact (r1/2 &lt; 30 pc), relatively massive (0.5 × 105 ≲ M⋆/M⊙ ≲ 5 × 105), self-bound stellar clusters form at 11 ≳ z ≳ 5 in progenitors with $M_{\rm vir} \approx 10^9\, \mathrm{M}_{\odot }$. Cluster formation is triggered when at least $10^7\, \mathrm{M}_{\odot }$ of dense, turbulent gas reaches $\Sigma _{\rm gas} \approx 10^4\, {\rm M}_\odot \, {\rm pc}^{-2}$ as a result of the compressive effects of supernova feedback or from cloud–cloud collisions. The clusters can survive for $2-3\, {\rm Gyr}$; absent numerical effects, they could possibly survive substantially longer, perhaps to z = 0. The longest lived clusters are those that form at significant distance – several hundreds of pc – from their host galaxy. We therefore predict that globular clusters forming in progenitors of present-day dwarf galaxies will be offset from any pre-existing stars within their host dark matter haloes as opposed to deeply embedded within a well-defined galaxy. Properties of the nascent clusters are consistent with observations of some of the faintest and most compact high-redshift sources in Hubble Space Telescope lensing fields and are at the edge of what will be detectable as point sources in deep imaging of non-lensed fields with JWST. By contrast, the star clusters’ host galaxies will remain undetectable.
Diagnosing the ejecta properties of engine-driven supernovae from observables in their initial phase
Authors: Maeda Keiichi , Suzuki Akihiro , Izzo Luca 
Published: April 2023

ABSTRACT
Engine-driven explosions with continuous energy input from the central system have been suggested for supernovae (SNe) associated with a Gamma-Ray Burst (GRB), superluminous SNe (SLSNe), and at least a fraction of broad-lined SNe Ic (SNe Ic-BL) even without an associated GRB. In the present work, we investigate observational consequences in this scenario, focusing on the case where the energy injection is sufficiently brief, which has been suggested for GRB-SNe. We construct a simplified, spherical ejecta model sequence taking into account the major effects of the central engine; composition mixing, density structure, and the outermost ejecta velocity. Unlike most of the previous works for GRB-SNe, we solve the formation of the photosphere self-consistently, with which we can predict the photometric and spectroscopic observables. We find that these ejecta properties strongly affect their observational appearance in the initial phase (≲ a week since the explosion), highlighted by blended lines suffering from higher-velocity absorptions for the flatter density distribution and/or higher outermost ejeca velocity. This behaviour also affects the multiband light curves in a non-monotonic way. Prompt follow-up observations starting immediately after the explosion thus provides key diagnostics to unveil the nature of the central engine behind GRB-SNe and SNe Ic-BL. For SN 2017iuk associated with GRB 171205A these diagnosing observational data are available, and we show that the expected structure from the engine-driven explosion, i.e. a flat power-law density structure extending up to ≳100 000 km s−1, can explain the observed spectral evolution reasonably well.
The X-ray variation of M81* resolved by Chandra and NuSTAR
Authors: Niu Shu , Xie Fu-Guo , Wang Q Daniel , Ji Li , Yuan Feng , Long Min 
Published: April 2023

ABSTRACT
Despite advances in our understanding of low-luminosity active galactic nuclei (LLAGNs), the fundamental details about the mechanisms of radiation and flare/outburst in hot accretion flow are still largely missing. We have systematically analysed the archival Chandra and NuSTAR X-ray data of the nearby LLAGN M81*, whose Lbol ∼ 10−5LEdd. Through a detailed study of X-ray light curve and spectral properties, we find that the X-ray continuum emission of the power-law shape more likely originates from inverse Compton scattering within the hot accretion flow. In contrast to Sgr A*, flares are rare in M81*. Low-amplitude variation can only be observed in soft X-ray band (amplitude usually ≲2). Several simple models are tested, including sinusoidal-like and quasi-periodical. Based on a comparison of the dramatic differences of flare properties among Sgr A*, M31*, and M81*, we find that, when the differences in both the accretion rate and the black hole mass are considered, the flares in LLAGNs can be understood universally in a magnetohydrodynamical model.
Structural gray matter alterations in glioblastoma and high-grade glioma—A potential biomarker of survival
Authors: Lamichhane Bidhan , Luckett Patrick H , Dierker Donna , Yun Park Ki , Burton Harold , Olufawo Michael , Trevino Gabriel , Lee John J , Daniel Andy G S , Hacker Carl D , Marcus Daniel S , Shimony Joshua S , Leuthardt Eric C 
Published: April 2023

Abstract

Background
Patients with glioblastoma (GBM) and high-grade glioma (HGG, World Health Organization [WHO] grade IV glioma) have a poor prognosis. Consequently, there is an unmet clinical need for accessible and noninvasively acquired predictive biomarkers of overall survival in patients. This study evaluated morphological changes in the brain separated from the tumor invasion site (ie, contralateral hemisphere). Specifically, we examined the prognostic value of widespread alterations of cortical thickness (CT) in GBM/HGG patients.

Methods
We used FreeSurfer, applied with high-resolution T1-weighted MRI, to examine CT, evaluated prior to standard treatment with surgery and chemoradiation in patients (GBM/HGG, N = 162, mean age 61.3 years) and 127 healthy controls (HC; 61.9 years mean age). We then compared CT in patients to HC and studied patients’ associated changes in CT as a potential biomarker of overall survival.

Results
Compared to HC cases, patients had thinner gray matter in the contralesional hemisphere at the time of tumor diagnosis. patients had significant cortical thinning in parietal, temporal, and occipital lobes. Fourteen cortical parcels showed reduced CT, whereas in 5, it was thicker in patients’ cases. Notably, CT in the contralesional hemisphere, various lobes, and parcels was predictive of overall survival. A machine learning classification algorithm showed that CT could differentiate short- and long-term survival patients with an accuracy of 83.3%.

Conclusions
These findings identify previously unnoticed structural changes in the cortex located in the hemisphere contralateral to the primary tumor mass. Observed changes in CT may have prognostic value, which could influence care and treatment planning for individual patients.
An Automated, Online Feasibility Randomized Controlled Trial of a Just-In-Time Adaptive Intervention for Smoking Cessation (Quit Sense)
Authors: Naughton Felix , Hope Aimie , Siegele-Brown Chloë , Grant Kelly , Barton Garry , Notley Caitlin , Mascolo Cecilia , Coleman Tim , Shepstone Lee , Sutton Stephen , Prevost A Toby , Crane David , Greaves Felix , High Juliet 
Published: April 2023

Abstract

Introduction
Learned smoking cues from a smoker’s environment are a major cause of lapse and relapse. Quit Sense, a theory-guided Just-In-Time Adaptive Intervention smartphone app, aims to help smokers learn about their situational smoking cues and provide in-the-moment support to help manage these when quitting.

Methods
A two-arm feasibility randomized controlled trial (N = 209) to estimate parameters to inform a definitive evaluation. Smoker’s willing to make a quit attempt were recruited using online paid-for adverts and randomized to “usual care” (text message referral to NHS SmokeFree website) or “usual care” plus a text message invitation to install Quit Sense. Procedures, excluding manual follow-up for nonresponders, were automated. Follow-up at 6 weeks and 6 months included feasibility, intervention engagement, smoking-related, and economic outcomes. Abstinence was verified using cotinine assessment from posted saliva samples.

Results
Self-reported smoking outcome completion rates at 6 months were 77% (95% CI 71%, 82%), viable saliva sample return rate was 39% (95% CI 24%, 54%), and health economic data 70% (95% CI 64%, 77%). Among Quit Sense participants, 75% (95% CI 67%, 83%) installed the app and set a quit date and, of those, 51% engaged for more than one week. The 6-month biochemically verified sustained abstinence rate (anticipated primary outcome for definitive trial), was 11.5% (12/104) among Quit Sense participants and 2.9% (3/105) for usual care (adjusted odds ratio = 4.57, 95% CIs 1.23, 16.94). No evidence of between-group differences in hypothesized mechanisms of action was found.

Conclusions
Evaluation feasibility was demonstrated alongside evidence supporting the effectiveness potential of Quit Sense.

Implications
Running a primarily automated trial to initially evaluate Quit Sense was feasible, resulting in modest recruitment costs and researcher time, and high trial engagement. When invited, as part of trial participation, to install a smoking cessation app, most participants are likely to do so, and, for those using Quit Sense, an estimated one-half will engage with it for more than 1 week. Evidence that Quit Sense may increase verified abstinence at 6-month follow-up, relative to usual care, was generated, although low saliva return rates to verify smoking status contributed to considerable imprecision in the effect size estimate.
Effect of Messaging Content on Engagement With a Short Messaging Service for Perioperative Smoking Cessation
Authors: Jose Thulasee , Cha Sarah , Graham Amanda L , Amato Michael S , Schroeder Darrell R , Warner David O 
Published: April 2023

Abstract

Introduction
We determined whether a tobacco cessation intervention targeting brief perioperative abstinence (“quit for a bit”) increased engagement of surgical patients with treatment compared with an intervention targeting long-term postoperative abstinence (“quit for good”).

Aims and Methods
Surgical patients who smoke were stratified according to intended duration of postoperative abstinence, and then randomized within strata to receive either a “quit for a bit” or a “quit for good” intervention. Both employed initial brief counseling and short message service (SMS) to deliver treatment up to 30 days after surgery. The primary outcome of treatment engagement was defined as the rate at which subjects actively responded to system requests delivered via SMS.

Results
The engagement index did not differ between intervention groups (median [25th, 75th] of 23.7% [8.8, 46.0] for “quit for a bit” group (n = 48) and 22.2% [4.8, 46.0] for “quit for good” group (n = 50), p = .74), nor did the proportion of patients continuing SMS use after study completion (33% and 28%, respectively). Exploratory abstinence outcomes on the morning of surgery and 7 and 30 days after surgery did not differ between groups. Program satisfaction was high in both groups and did not differ. There was no significant interaction between intended abstinence duration and any outcome, ie, alignment of intent with intervention did not affect engagement.

Conclusions
Tobacco cessation treatment delivered via SMS was well accepted by surgical patients. Tailoring an SMS intervention to focus on the benefits of short-term abstinence for surgical patients did not increase engagement in treatment or perioperative abstinence rates.

Implications
Treatment of surgical patients for tobacco use is efficacious and reduces postoperative complications. However, implementation in clinical practice has proved challenging, and new methods of engaging these patients in cessation treatment are needed. We found that tobacco use treatment delivered via SMS was feasible and well utilized by surgical patients. Tailoring an SMS intervention to focus on the benefits of short-term abstinence for surgical patients did not increase engagement in treatment or perioperative abstinence rates.

Clinical Trial Number
NCT03839043. Registry URL: https://clinicaltrials.gov/ct2/show/NCT03839043
Ostrogradsky mode in scalar–tensor theories with higher-order derivative couplings to matter
Authors: Naruko Atsushi , Saito Ryo , Tanahashi Norihiro , Yamauchi Daisuke 
Published: April 2023

Abstract
Metric transformation is a tool to find a new theory of gravity beyond general relativity. The gravity action is guaranteed to be free from the dangerous Ostrogradsky mode as long as the metric transformation is regular and invertible. Various degenerate higher-order scalar–tensor theories without extra degrees of freedom have been found through the metric transformation with a scalar field and its derivatives. In this work, we examine how a matter coupling changes the degeneracy for a theory generated from the Horndeski theory through the metric transformation with the second derivative of a scalar field, taking a minimally coupled free scalar field as the matter field. When the transformation is invertible, this theory is equivalent to the Horndeski theory with a higher-order derivative coupling to the matter scalar field. Working in this Horndeski frame and the unitary gauge, we find that the degeneracy conditions are solvable and the matter metric must have a certain structure to remove the Ostrogradsky mode.
An update on pathogenesis of inflammatory disorders with its management
Authors: Bansal Palak , Verma Diksha , Singh Tamber Sukhbir , Sharma Ramica 
Published: April 2023

Abstract

Objectives
Pathogenesis of inflammation has been linked to a variety of diseases, so exploring the cause of inflammation is very much crucial. Once the cause is predicted then the treatment of the inflammation and related disorders become predictable.

Key findings
An inflammatory response is the immune system’s response to harmful stimuli that can be triggered by pathogens, damaged cells, and toxic compounds. Inflammation and the diseases associated with it are becoming more popular. There are several complications that arise due to inflammation, such as cardiovascular disease, rheumatoid arthritis, gout, asthma, etc. Inflammation results in plethora of events characterised by release of inflammatory cytokines activation of nuclear factor kappa-B, mitogen-activated protein kinase, Janus kinase signalling, and the activator of transcription (signal transducer and activator of transcription) pathway, facilitate the process of inflammation. Hence with this review, it will open the vista for new interventions used in the management of inflammatory disorders.

Summary
This review deals with the various inflammatory disorder and pathogenesis associated with them. This article opens a window to explore more relevant pharmacological treatment for the benefit of the society. Till date the medication that is available for the management of inflammatory diseases/disorders provides only symptomatic treatment and that is only to a limit. The medication such as steroids posses a serious adverse drug reactions and other option like disease modifying anti-rheumatic drugs/slow-acting anti-rheumatic drugs are not economical or budget friendly. Hence, with this review we can look for various targets that are beneficial in the management of inflammatory-related disorders.
Effect of a surgical skills month on intern performance in the orthopaedic in-training examination
Authors: Samade Richard , Scharschmidt Thomas J. 
Published: April 2023

Background:
The orthopaedic in-training examination (OITE) is an annual national assessment of knowledge in orthopaedic surgery residents. Our primary aim was to determine if intern performance in the OITE (measured by correct answers) differed before and after the adoption of a formal surgical skills month (SSM) in the residency curriculum. A secondary aim was to evaluate the relationship between intern OITE and post-graduate year two (PGY-2) scores.

Methods:
A single institution retrospective cohort study was performed, comparing orthopaedic surgery interns who took the OITE before (15 residents) and after (16 residents) the year 2013 (when an SSM was introduced). De-identified OITE raw and percentage correct scores were obtained from all resident records. Statistical testing included independent sample t test and linear regression, with a significance level of 0.05.

Results:
Comparison of OITE percentage of correct answers overall, between interns before and after 2013, showed a significant increase after initiating the SSM (44.8%±4.13% vs. 49.9%±8.44%, P=0.0414). In addition, regression analysis demonstrated a positive linear relationship between intern and PGY-2 OITE scores after the SSM was implemented (R
2=0.380, P=0.011, β=0.424, CI: 0.1135341 –1.190913).

Conclusion:
Implementation of an SSM led to increased intern OITE scores. Moreover, intern OITE scores were more predictive of PGY-2 scores after SSM implementation. Earlier education (such as a surgical skills month) for orthopaedic surgery interns can aid knowledge acquisition and career development at the beginning of their training.

Level of Evidence:
Level III.
Myxoinflammatory Fibroblastic Sarcoma of the Hand
Authors: Alhumaidan Mohammed I. , Bin Makhashen Maraei , Bassas Abdulelah F. , Mater Mohammed E. , Alsufayan Faris A. , Alfaqeeh Faisal A. 
Published: April 2023

Summary:
Myxoinflammatory fibroblastic sarcoma is an ultra-rare tumor type with a prevalence of fewer than two per 100,000 people. The tumor poses a challenge because it can be misdiagnosed as a benign lesion in clinical and radiological investigations, causing serious morbidity in patients. We present the case of a 33-year-old patient who presented with painless hand swelling that was misdiagnosed as lymphaticovenous malformation based on magnetic resonance imaging. The patient underwent surgical excision, and myxoinflammatory fibroblastic sarcoma was diagnosed postoperatively. All surgical interventions failed to achieve negative margin. A decision to start radiotherapy was made, and tissue convergence was done temporally using acellular dermal matrix and split-thickness skin graft. On patient follow-up, the graft had taken well, and the patient was undergoing radiotherapy sessions with a plan for permanent hand reconstruction after negative margins are achieved. Based on this case report, we identified that magnetic resonance imaging is not yet a reliable method to diagnose myxoinflammatory fibroblastic sarcoma. Therefore, implementing a multidisciplinary team approach, a preoperative core needle biopsy, planned surgical intervention, and early involvement of radiotherapy is recommended to minimize morbidity. We strongly urge establishing a sarcoma specialized treatment center in the region to limit patient morbidity.
Farnesoid X receptor alpha ligands inhibit HDV in vitro replication and virion infectivity
Authors: Legrand Anne-Flore , Lucifora Julie , Lacombe Benoît , Ménard Camille , Michelet Maud , Foca Adrien , Abrial Pauline , Salvetti Anna , Rivoire Michel , Lotteau Vincent , Durantel David , André Patrice , Ramière Christophe 
Published: April 2023

Background and Aims:
HDV, a satellite of HBV, is responsible for the most severe form of human viral hepatitis, for which curative therapy is still awaited. Both HBV and HDV use the hepatic transporter of bile acids (ie, Na+-taurocholate cotransporting polypeptide) to enter hepatocytes. We have previously shown that ligands of the farnesoid-X-receptor alpha (FXR), a master regulator of bile acids metabolism, inhibit HBV replication. Here we asked whether FXR ligands can also control HDV infection.

Approach and Results:

In vitro HDV monoinfections or HDV/HBV coinfections and superinfections were performed in differentiated HepaRG cells (dHepaRG) and primary human hepatocytes. Following treatment with FXR ligands, HDV RNAs and antigens were analyzed by RT-qPCR, northern blot, immunofluorescence, and western blot. Virus secretion was studied by RNA quantification in supernatants, and the infectivity of secreted HDV particles was measured by reinfection of naive HuH7.5-Na+-taurocholate cotransporting polypeptide cells. In HDV/HBV superinfection models, a 10-day treatment with FXR ligand GW4064 decreased intracellular HDV RNAs by 60% and 40% in dHepaRG cells and primary human hepatocytes, respectively. Both HDV genomic and antigenomic RNAs were affected by treatment, which also reduced the amount of intracellular delta antigen. This antiviral effect was also observed in HDV monoinfected dHepaRG cells, abolished by FXR loss of function, and reproduced with other FXR ligands. In HBV/HDV coinfected dHepaRG cells, HDV secretion was decreased by 60% and virion-specific infectivity by >95%.

Conclusions:
FXR ligands both inhibit directly (ie, independently of anti-HBV activity) and indirectly (ie, dependently of anti-HBV activity) the replication, secretion, and infectivity of HDV. The overall anti-HDV activity was superior to that obtained with interferon-α, highlighting the therapeutic potential of FXR ligands in HDV-infected patients.