bluuebunny/crossref_metadata_2025_split huggingface dataset:
The predictive factors for resorption of lumbar intervertebral disc herniation
Authors: Sanginov A. J. , Isakov I. D. , Belozerov V. V. , Mushkachev E. A. , Peleganchuk A. V. 
Published: January 2025

Objective. To determine the timing and to identify predictive factors of resorption of lumbar intervertebral disc herniation.Material and Methods. This study is retrospective cohort and is devoted to the study of two groups of patients: Group 1 with herniated disc resorption and Group 2 with no resorption. All patients underwent MRI of the lumbar spine at the onset of initial symptoms, and the second study was conducted during the second visit. Based on the MRI results, the following parameters were assessed: the degree of intervertebral disc degeneration according to the Pfirrmann classification, the degree of facet joint degeneration according to the Grogan classification, the type of hernia, the degree of migration of the hernial fragment according to the Komori classification, Modic changes, the state of the endplates according to the Rajasekaran classification, the presence of retrolisthesis and the presence of resorption of the hernial fragment in dynamics. The Syngo.via workstation was used to measure the volume of the hernial fragment. Resorption of a disc herniation was considered to be a decrease in its volume by more than 50 % of the initial value with mandatory relief of radicular pain syndrome. The identification of resorption predictors was performed by building logistic regression models. Single-factor models were used to identify individual predictors associated with the target event. For continuous indicators, the ROC analysis identified the maximum cut-point values according to the Youden’s index.Results. Group 1 included 141 patients, and Group 2 (comparison) – 93. Statistically significant differences between groups were found in several parameters. The average age of patients was 6 years younger; the interval between MRI studies was on average 2 months longer; and the protrusive type hernias were more in Group 2 than in Group 1. Gender, body mass index, the presence of retrolisthesis and smoking habit did not differ significantly between the groups. In Group 2, there were more cases of hernia at the L5–S1 level, which is associated with a higher incidence of hernia at this level. Using logistic regression models, it was revealed that hernia volume, hernia type according to the Komori classification, body mass index and Modic changes are significant factors for hernia resorption. A hernia volume of more than 1.1 cm3, no Modic change, hernia types II and III according to Komori, and body mass index of less than 30.24 increase the chances of disc herniation resorption.Conclusion. The average time to resorption of herniated lumbar disc is 5.5 months. Factors that predict the resorption include types II and III of hernia according to the Komori classification (correspond to sequestered herniation), the absence of Modic changes, hernial fragment volume larger than 1.1 cm3, and body mass index less than 30.24.
Evolution of autoimmune diagnostics over the past 10 years: lessons learned from the UK NEQAS external quality assessment EQA programs
Authors: Garrafa Emirena , Carbone Teresa , Infantino Maria , Anzivino Pierluigi , Boni Michela , Ghisellini Sara , Muraro Valentina , Roselli Daniele , Trevisan Maria Teresa , Patel Dina , Bizzaro Nicola 
Published: January 2025

Abstract

Objectives
External quality assessment (EQA) programs play a pivotal role in harmonizing laboratory practices, offering users a benchmark system to evaluate their own performance and identify areas requiring improvement. The objective of this study was to go through and analyze the UK NEQAS “Immunology, Immunochemistry and Allergy” EQA reports between 2012 and 2021 to assess the overall level of harmonization in autoimmune diagnostics and identify areas requiring improvement for future actions.

Methods
The EQA programs reviewed included anti-nuclear (ANA), anti-dsDNA, anti-centromere, anti-extractable nuclear antigen (ENA), anti-phospholipids, anti-neutrophil cytoplasm (ANCA), anti-proteinase 3 (PR3), anti-myeloperoxidase (MPO), anti-glomerular basement membrane (GBM), rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA), mitochondrial (AMA), liver-kidney-microsomal (LKM), smooth muscle (ASMA), APCA, and celiac disease antibodies.

Results
In the analyzed period, the number in participating laboratories showed an increase for almost all programs. Among solid phase methods, the use of ELISA techniques showed a progressive reduction, while new technologies, such as the fluoroenzymatic immunoassay, chemiluminescence immunoassay, Luminex and immunoblot showed an increased number of users. The number of results complying with the expected negative or positive target slightly increased for almost all antibodies in the last decade. A description of the most frequent causes of mistakes or misinterpretation for each specific test and method is also provided in this study.

Conclusions
Although numerous challenges need to be addressed in the area of autoantibody detection to enhance testing quality and attain higher harmonization, the period analyzed revealed that the ever-expanding range of autoantibodies, coupled with the introduction of new tests and methodologies and the advent of automated platforms, has brought about significant changes in autoimmune diagnostics.
Cognitive biases in osteopathic diagnosis: a mixed study among French osteopaths
Authors: Siffert Cassandra , Romanet François , Desmazières Marion , Drault Priscilla , Gourjon Géraud 
Published: January 2025

Abstract

Objectives
Although cognitive biases are one of the most frequent causes of diagnostic errors, their influence remains underestimated in allied health professions, especially in osteopathy. Yet, a part of osteopathic clinical reasoning and diagnosis rely on the practitioner’s intuition and subjective haptic perceptions. The aim of this study is to highlight links between the cognitive biases perceived by the practitioner to understand cognitive patterns during osteopathic diagnosis, and to suggest debiasing strategies.

Methods
A mixed method based on an explanatory sequential type is used. (QUAN→QUAL). A quantitative cross-sectional survey of 272 French osteopaths and three focus groups including 24 osteopaths were carried out. The quantitative analysis includes multinominal logistic regression models and multiple correspondence analysis. The qualitative analysis is based on the framework method (within thematic analysis) and followed a step-by-step guide (Gale et al.).

Results
Among 19 selected biases, osteopaths feel to be affected by 9.4 ± 0.28 biases (range [1−19], median=9). Some presumed biases would be associated, and socio-demographic (gender, age) and professional (experience and types of practice) factors would modify how practitioners perceive the presence of biases. Main debiasing solutions are supervision and transcultural clinical competences.

Conclusions
Osteopaths believe their diagnosis is impaired by the presence of cognitive biases as observed in clinical reality. Some biases are shared with medical doctors, but others are more specific to osteopaths, such as confirmation bias. To reduce their effect, the practitioner needs to be aware of these cognitive patterns of clinical reasoning, understand the patient and himself better, and use objective tests.
Remote quantum networks based on quantum memories
Authors: Zhu Tian-Xiang , Liu Xiao , Zhou Zong-Quan , Li Chuan-Feng 
Published: January 2025

Abstract
Quantum networks, capable of transmitting arbitrary quantum states, provide a foundation for a wide range of quantum applications, including distributed quantum computing, distributed quantum sensing, and quantum communication. Photons are the natural carrier of information in quantum networks, but the exponential loss of optical fiber channels prevents the construction of large-scale quantum networks. A potential solution is implementing quantum repeaters based on quantum memories, which can efficiently establish long-distance entanglement from short-distance entanglement. In the past decades, intense efforts have been devoted to constructing large-scale quantum networks based on various atomic quantum memories. In this Perspective, we present a concise overview of current advancements in remote quantum networks, elucidate the imminent challenges that must be addressed, and discuss the future directions.
Bioluminescent Activity Preservation of Photobacterium phosphoreum Using Microbial Exopolysaccharide Compositions
Authors: Hretskyi І.O. , Dankevych L.A. , Leonova N.O. 
Published: January 2025

Biosensorics is a new branch of analytical biotechnology, one of the main directions of which is the development of electrochemical biosensors. Microorganisms capable of bioluminescence are often used in biosensor systems. Such microorganisms include marine bioluminescent bacteria Aliivibrio ficsheri, Vibrio campbellii, Vibrio harveyi, Photobacterium phosphoreum, etc. Since these marine microorganisms require rather complex environments for their cultivation and maintenance of the luminescence process, the development of an environment for improving the bioluminescence process is extremely urgent. In the course of many years of research, employees of the Department of Phytopathogenic Bacteria and other departments of the Zabolotny Institute of Microbiology and Virology of Ukrainian National Academy of Sciences have developed a number of gel preparations using copolymer EPAA (based on the microbial exopolysaccharide (EPS) xanthan and polyacrylamide) and lipcogenic compositions based on it. In particular, gel preparations of Pantoea agglomérans, and Bradyrhizobium jaronicum, Bacillus thuringiensis have been developed. The use of these compositions made it possible to improve and prolong the storage titers of these drugs and the output of certain metabolites. Considering this, the aim of our research was the development of a gel medium using EPS, copolymer EPAA, and gel compositions based on it, which could ensure long-term and high- luminescence of Photobacterium phosphoreum bacteria. Methods. Classic microbiological and static methods were used in the research. Results. It is shown that the optimal medium for the cultivation of P. phosphoreum B-7071 based on the preservation of luminescence intensity indicators used in microbial biosensors is a mixture of 2% lipocogenic composition D (70% EPAA + 30% EPS–xanthan) and 3% NaCl solution in a ratio of 1:1 for 50% occupancy of the polypropylene container. Conclusions. The results obtained correlate with the data of the literature since it is shown that, like in the experiments with P. phosphoreum B-7071, the addition of EPAA, EPS, and/or lipcogenic compositions based on them to the culture medium of microorganisms has a positive effect on the processes of growth and development of this strain as well as their synthesis of separate groups of metabolites associated with bioluminescence.
Evaluating the Effectiveness of the High Diploma in Teacher Education Program at the University of Jordan as Perceived by EFL Student–Teachers
Authors: Abu- Helu Sahar Yacoub , Masadeh Areej Yousef AL , Damra Hebah M. 
Published: January 2025

This study aimed to evaluate the effectiveness of the High Diploma in Teacher Education Program at the University of Jordan as Perceived by EFL Student-Teachers, and to investigate statistically significant differences (α = 0.05) in the EFL student-teachers’ estimations of the program’s effectiveness due to their gender. The sample of this study consisted of 46 EFL student-teachers registered in the High Diploma in Teacher Education Program at the University of Jordan, during the academic year 2022-2023. The total number of EFL student-teachers consisted of 54 students distributed to two sections. The sample was purposefully chosen upon availability from the two EFL student-teacher sections which consisted of 36 female student-teachers and represented 78% of the sample, and 10 male student-teachers which represented 22% of the chosen sample. To achieve the aims of the study, a 37 Likert item survey was distributed on three main domains of teachers’ standards and was applied to the sample of the study. The results of the study showed that the effectiveness of the High Diploma in Teacher Education program at the University of Jordan on the overall and separate scale was high; standard 3 (Professional Ethics) ranked first, then standard 2 (Professional Practice) ranked second. Finally, standard 1 (Professional Knowledge) ranked third. On the other hand, the results of the study showed that there were statistically significant differences (α= 0.05) in the EFL student-teachers’ estimations of the program effectiveness due to their gender in favor of female student-teachers.
Genetic and Technological Factors in legal Regulation of Food Security in the Russian Federation
Authors: Mityakina N. M. , Novikova A. E. , Fedoryashchenko A. S. 
Published: January 2025

Contemporary socioeconomic, geopolitical, and technological conditions pose unprecedented threats and challenges. Recent years have witnessed a transformation of the world order, resulting in the establishment of new rules and principles of human coexistence. Such global transformations affect all public spheres, imposing special requirements on the quality of measures to ensure national security at both governmental and individual levels. Therefore, all aspects of national security, including food security, is increasingly attracting research attention.In this article, we set out to identify recent trends in food policy in terms of using genetic technologies to ensure food security in the Russian Federation and to formulate proposals for improving the legal regulation of this area. The research is conducted by fulfilling the following tasks: (1) an analysis of Russia’ strategic and legal documents in order to assess the current status of legal support for food security in the country; (2) an analysis of modern scientific concepts of safety and the impact of genetic technologies, including gene editing technologies, on agriculture; (3) formulation of proposals for improving the current legislation.Our research has revealed the need to develop the state policy and legal regulation of food security based on modern approaches to the role of genetic technologies. The importance of legal regulation of genetic technologies, including genetic editing technologies and technologies related to agriculture and food industry, is highlighted. Agrarian legislation should reflect the main provisions of the state policy concerning the support and promotion of genetic technologies in the field of food and animal feed production.
Association of Severity of Coronary Artery Disease With Traditional Risk Factors, Clinical Characteristics and Carotid Plaque Burden in Patients With Acute Coronary Syndrome
Authors: Bershtein L. L. , Lunina M. D. , Evdokimov D. S. , Nayden T. V. , Gumerova V. E. , Kochanov I. N. , Ivanov A. A. , Boldueva S. A. , Resnyanskaya E. D. , Zbyshevskaya E. V. , Evtushenko A. E. , Piltakyan V. Kh. , Sayganov S. A. 
Published: January 2025

Aim. To study the associations between risk factors, clinical characteristics, severity of brachiocephalic artery (BCA) atherosclerosis and severity of coronary artery (CA) disease in patients with acute coronary syndrome (ACS).Material and methods. The study included patients with any type of ACS and obstructive coronary artery disease confirmed by coronary angiography. A quantitative analysis of coronary angiography data was performed with an assessment of the number of CAs with significant stenosis and calculation of the SYNTAX score. The major clinical and laboratory parameters that are risk factors for atherosclerosis and/or affect the cardiovascular prognosis were assessed; for patients with ACS without ST segment elevation (NSTE-ACS), the risk score was calculated by the GRACE scale. The BCA ultrasound examination was performed with a quantitative analysis of atherosclerotic burden.Results. The study included 312 patients aged 64 [56, 72] years; the proportion of men was 69.2%. The frequency of lesions of 1, 2 and 3 coronary arteries was 34.6, 35.3, and 30.1%, respectively; the SYNTAX score was 14 [9, 21]. According to the results of univariate analysis, the number of stenotic CAs and the SYNTAX score were associated with age, smoking history, history of ischemic heart disease, diabetes mellitus (DM), the presence of non-stenotic CA lesions, the GRACE score in NSTE-ACS, and the Charlson comorbidity index. An inverse correlation was found for the level of physical activity and a slightly weaker one for the glomerular filtration rate and high-density lipoprotein cholesterol (HDL-C). In multivariate models, the only independent predictors of the number of stenotic CAs were HDL-C (odds ratio, OR 0.37, 95% confidence interval, CI 0.17-0.81; p=0.012) and the smoking history (OR 1.30, 95% CI 1.12-1.52; p=0.001), a coefficient of determination of the model R2 of 18%, SYNTAX score with a history of myocardial infarction (ß=6.40, 95% CI 3.22-9.58; p<0.001), insulin-dependent DM (ß=9.44, 95% CI 3.50-15.38; p=0.002), GRACE score for NSTE-ACS (ß=0.06, 95% CI 0.01-0.11; p<0.014), and a coefficient of determination of the model R2=20%.Conclusion. Patients with ACS show significant, independent associations of the severity of coronary atherosclerosis with HDL-C, smoking duration, history of myocardial infarction, insulin-dependent diabetes, and the GRACE score in NSTE-ACS. Variability in the severity of CA lesions is only to a small extent determined by risk factors, clinical characteristics, and the severity of concomitant carotid atherosclerosis.
Interiorismo de bajo costo en viviendas rurales en la provincia del Azuay
Authors: Mejía-Coronel Diana Paulina , Zhindón-Duarte Jonnathan Andrés 
Published: January 2025

La presente investigación tiene un enfoque cualitativo con alcance exploratorio y de aplicación y ha procurado solucionar un problema en el espacio interior de usuarios en viviendas que tengan capacidades económicas limitadas, mediante el diseño con materiales de bajo costo, para mejorar su calidad de vida. Para lograr todo ello la metodología empleada partió de un análisis bibliográfico, se trabajó con estudiantes de los últimos ciclos de la Carrera de Diseño Interior de la Facultad de Artes, de la Universidad de Cuenca para el levantamiento de información. Posteriormente se realizó la selección de 6 viviendas en el sector de Llulluchas- Sayausí, Cuenca, por parte de los docentes tutores, representando las más emergentes de la zona como prioritarias. Seguidamente los estudiantes realizaron fichas de levantamiento arquitectónico de las viviendas, y también resolvieron entrevistas para descubrir problemas de diseño interior. Mediante los datos recolectados los alumnos plantearon soluciones interioristas a los espacios de una manera formal, funcional y constructiva bajo la tutoría de los docentes para generar propuestas de diseño con material de bajo costo. El anteproyecto fue aprobado por los usuarios según sus necesidades y experiencias en el uso de mobiliario y espacio, esta fase fue motivacional para arrancar con la gestión de materiales a empresas privadas, el último paso fue la socialización de las propuestas por parte de los estudiantes hacia los usuarios. Al finalizar el proyecto se pudo evidenciar que se pueden generar soluciones interioristas de vivienda a bajo costo, mejorando la comodidad y seguridad a las familias.
Identifying the pedoclimatic conditions most critical in the susceptibility of a grapevine cultivar to esca disease
Authors: Hofstetter Valérie , Monod Vinciane , Wilhelm Matthieu , Viret Olivier , Gindro Katia , Croll Daniel , Zufferey Vivian 
Published: January 2025

Esca, one of the most destructive grapevine trunk diseases, is still poorly understood. As grapevine cultivars vary widely in their susceptibility to esca, we designed a four-year experiment to identify the environmental factors that influence the expression of the disease in a susceptible cultivar. We collected epidemiological and physiological data once a year for four consecutive years in 19 vineyard plots located in four wine-growing regions of Western Switzerland. We compared these data with climatic data obtained from weather stations for these same plots for four years and over the long term. We also estimated the soil water holding capacity of each plot. Confounding factors were minimal because all vineyards were planted in 2003 with the same cultivar and all plants grafted in the same nursery with genetically homogeneous grafting material. Principal component and regression analyses of combined epidemiological, biotic and pedoclimatic data identified a positive correlation between soil water retention capacity and plant mortality due to esca. These analyses also showed that leaf disease symptoms and apoplexy are more frequent when cold and wet periods are followed–or alternate with–hot and dry periods, and that apoplexy occurs more frequently when weather conditions change abruptly (a cold and wet May followed by a hot June) and deviate significantly from long-term climatic conditions. Regression analyses show that the soil water holding capacity impacts less the disease expression when the climate is warm and dry, both at the regional and year-specific levels. Having identified the most important environmental factors towards the expression of esca, this study allows recommendations to be given to the winegrowers for the cultivar studied but can also be used as a model to identify the environmental factors that influence the expression of fungal diseases in other grapevine cultivars and other grapevine trunk diseases.
EVALUATION OF THE USE OF STAR FRUIT LEAF ADHESIVE ON THE COMPRESSIVE STRENGTH AND DURABILITY OF BRIQUETTES MADE FROM DURIAN PEEL CHARCOAL AS AN ALTERNATIVE FUEL
Authors: Umul Istikhomah , Rizki Annisa , Yusuf Madjid , Harjanto Harjanto 
Published: January 2025

Fossil energy has a limited amount and is not renewable. Therefore, renewable energy sources are needed so as not to depend on fossil energy sources. This study aims to evaluate the effect of the type and percentage of adhesive material used, on the compressive strength and durability of durian peel briquettes. The main material used in making briquettes is durian peel. The adhesive material used is star fruit leaves with a percentage of 0%, 2%, 4%, 6%, 8%, and 10%. In this study, characterization tests were carried out on the briquettes produced with reference to ISO 17225-1 and ASAE S 269.4. The results showed that the best compressive strength value with 0% adhesive concentration (8.51kg/cm2) and the best durability value with 8% adhesive concentration (92.7%). Based on the test results, it is known that the addition of adhesive material causes the compressive strength value and durability value to decrease.
Keywords: Briquettes, Durian Peel, Adhesive, Alternative Energy