bluuebunny/crossref_metadata_2025_split huggingface dataset:
1851-PUB: Intractable Diabetic Ketoacidosis with Enfortumab Vedotin
Authors: ELAHI AMNA , DURON JAVIER , PORTER TAMA 
Published: June 2023

Enfortumab Vedotin (EV) is an antibody-drug conjugate for metastatic urothelial carcinoma. Hyperglycemia and diabetic ketoacidosis (DKA) have been reported in patients using EV. The incidence increases with higher BMI. The one case report available on the association between EV and DKA resulted in development of multiorgan failure and death. This case, however, describes a positive outcome with recovery from DKA.
We present a case of a 59 year-old Caucasian woman with morbid obesity, prediabetes and recurrent metastatic urothelial cell carcinoma who presented with hyperglycemia after 2 doses of EV. Labs were indicative of DKA without an infectious etiology. She was admitted to the ICU for intravenous insulin drip treatment. Hyperglycemia and ketosis persisted despite using a maximum insulin drip rate of 60 units/hour. Starvation ketosis was a factor, so a diet was started. On day 2, NPH insulin and prandial lispro were added along with the insulin drip, resulting in a total daily insulin dose of 1660 units. Nevertheless, hyperglycemia persisted. U-500 regular insulin was initiated and by day 4, the patient received a total of 2940 units of insulin in one day with normalized serum ketones. Insulin drip requirements decreased with blood glucose controlled solely on subcutaneous insulin. She remained euglycemic, so U-500 insulin was switched to daily glargine. Eventually, she was off all insulin and maintained blood glucose below 130 mg/dL. Work up for insulin resistance included a C-peptide of 42.6 ng/mL (normal 1.1-4.4) with glucose of 230 mg/dL, negative glutamic acid decarboxylase 65 and insulin antibodies, and a glucagon level of 213 pg/mL (normal ≤80) with glucose of 220 mg/dL.
Although the mechanism by which EV causes hyperglycemia is not known, this case illustrates that hyperglycemia was due to severe insulin resistance associated with EV. Understanding this, along with glycemic effects of targeted therapies with Vedotin are necessary to investigate the causal mechanism and treatment for EV related hyperglycemia/DKA.

Disclosure
A.Elahi: None. J.Duron: None. T.Porter: None.
761-P: Effect of Orforglipron vs. Placebo and Dulaglutide on Glycemic Control and Body Weight in Patients with Type 2 Diabetes
Authors: FRIAS JUAN P. , HSIA STANLEY H. , EYDE SARAH , LIU RONG , MA XIAOSU , KONIG MANIGE , KAZDA CHRISTOF M. , PRATT EDWARD J. , MATHER KIEREN J. , HAUPT AXEL , ROBINS DEBORAH A. 
Published: June 2023

Orforglipron [OFG (LY3502970)] is an oral, non-peptide, glucagon-like peptide-1 receptor agonist (GLP-1 RA).
The 26-week, randomized, double-blind, double placebo, phase 2 study enrolled 383 patients with type 2 diabetes (T2D) treated with diet, exercise, ± metformin. At baseline, mean age was 58.9 yr, HbA1c was 8.1%, and body weight (BW) was 100.3 kg. Patients were randomly assigned to OFG 3, 12, 24, 36, or 45 mg once daily, placebo (PBO), or dulaglutide 1.5 mg (dula). Protocols guided the initial OFG dose and escalation schemes. Primary endpoint was HbA1c change from baseline (CFB) at wk 26 for OFG vs PBO. Secondary endpoints included CFB at wk 26 in HbA1c for OFG vs dula, and CFB in fasting blood glucose (FBG) and body weight (BW) for OFG vs PBO and dula.
OFG resulted in improvements in glycemic control and BW (table). At wk 26, HbA1c reduction with OFG ranged from 1.19 to 2.10% vs PBO 0.43% (P&lt;0.001, all doses vs PBO). Significantly greater reductions in HbA1c were also noted with 12, 24, 36, and 45 mg OFG vs dula (p&lt;0.001). Most adverse events (AE) were gastrointestinal (nausea: PBO 5.5%, OFG 30.6%, dula 18.0%) and mild or moderate in severity.
OFG resulted in significant reductions in HbA1c, FBG, and BW with an AE profile consistent with other GLP-1RAs. OFG does not have food or water administration restrictions and may provide a safe, effective, and convenient oral treatment option for patients with T2D.

Disclosure
J.P.Frias: Advisory Panel; Becton, Dickinson and Company, Pfizer Inc., Sanofi, Consultant; Akero Therapeutics, Inc., 89bio, Inc., Aimmune, Boehringer Ingelheim Inc., Eli Lilly and Company, Carmot Therapeutics, Inc., Echosens, Merck & Co., Inc., Metacrine, Inc., Novo Nordisk, Pfizer Inc., Sanofi, Employee; Ionis Pharmaceuticals, Research Support; Akero Therapeutics, Inc., 89bio, Inc., Altimmune, Axcella Health Inc., Boehringer Ingelheim Inc., Eli Lilly and Company, Intercept Pharmaceuticals, Inc., Carmot Therapeutics, Inc., Janssen Pharmaceuticals, Inc., Madrigal Pharmaceuticals, Inc., Merck & Co., Inc., Metacrine, Inc., Novo Nordisk, Oramed Pharmaceuticals, Novartis, Pfizer Inc., Sanofi, Speaker's Bureau; Eli Lilly and Company, Sanofi. A.Haupt: Employee; Lilly, Stock/Shareholder; Lilly. D.A.Robins: None. S.H.Hsia: Research Support; Eli Lilly and Company. S.Eyde: None. R.Liu: None. X.Ma: Employee; Eli Lilly and Company, Stock/Shareholder; Eli Lilly and Company. M.Konig: None. C.M.Kazda: Employee; Eli Lilly and Company. E.J.Pratt: Employee; Eli Lilly and Company. K.J.Mather: Employee; Eli Lilly and Company.
De estetiska ämnenas didaktik; att göra ämnesinnehåll med kroppar, affekter, känslor och plats
Authors: Szatek Elsa 
Published: June 2023

Didaktikbegreppet figurerar oftast i relation med kursplaner och på förhand bestämda lärandemål i formella utbildningskontexter såsom skola och universitet. I den här artikeln undersöks hur didaktikbegreppet kan bli produktivt i relation till konstnärliga verksamheter som communityteater där innehållet oftast är platsspecifikt samt förhandlas fram mellan deltagare och ledare. Utifrån detta utforskas hur ämnesinnehållet i estetiska ämnen, med fokus på teater inom frivillig verksamhet, skapas av kroppar, affekter, känslor och plats. En utgångspunkt är att dessa aktörer blir centrala medproducenter av ämnesinnehåll när kursplaner saknas. Med inspiration från posthumanistiska teorier förstås aktörerna som både rörliga och oförutsägbara vilket skapar specifika förutsättningar både för hur teaterämnet tar form och för de estetiska ämnena generellt. Detta utforskas genom en utvidgad relationell didaktik vilken möjliggör fler aktörer än de mänskliga på den didaktiska arenan. Genom begreppet didaktisk musikalitet undersöks hur teaterledaren kan förhålla sig till ett ämnesinnehåll som är både rörligt och oförutsägbart samt i hög grad samskapas affektivt, kroppsligt och rumsligt.
ENGLISH ABSTRACT
Didactics for the aesthetic subjects; producing subject-matter through bodies, affects, feelings and place
Didactics as a concept is often connected with syllabuses and beforehand stated learning objectives in formal educational contexts such as schools. This article explores how didactics could become productive in relation with artistic and sitespecific settings such as community theatre where the content is negotiated between the leaders and the participants. The article explores how subject- content in aesthetic subjects, with focus on theatre in a community setting, is created through bodies, affects and space. A point of departure is that these actors become vital co-producers of the subject-matter in the absence of curriculum. Inspired by posthumanism, the actors are explored as agile and unpredictable thus creating specific conditions for the shaping of the theatre subject and the aesthetic subjects in general. This is examined through an extended relational didactic that enables human and non- uman participants in the didactic field. Through the concept of didactic musicality the article also explores the relationship between the theatre teacher and a subject-matter that is constantly changing through affects, bodies and space.
Properties of Rubber-Like Materials and their Blends in Wide Range of Temperatures – Experimental and Numerical Study
Authors: Konarzewski Marcin , Stankiewicz Michał , Sarzyński Marcin , Wieczorek Marcin , Czerwińska Magdalena , Prasuła Piotr , Panowicz Robert 
Published: June 2023

Abstract
Elastomers are widely used in many industries. Their use requires thorough knowledge of their strength and stiffness parameters over a wide temperature range. However, determination of the parameters of such materials is still a challenge. Therefore, the paper presents research methodology allowing determination of the properties of rubber-like materials in a wide range of stretch and temperatures (from +50°C to −25°C) by using the example of styrene-butadiene rubber (SBR) and natural rubber (NR) elastomers. Additionally, two blends, chloroprene rubber/nitrile-butadiene rubber (CR/NBR) and NR/SBR blends, were also considered. Based on physical premises, a polynomial and Arruda–Boyce hyperelastic constitutive models parameters were determined using two different methods, namely curve-fitting and the successive response surface method.
Quality attributes and antioxidant activities of meat of broiler chickens administered aqueous Lagenaria breviflora
Authors: Ekunseitan Deji Abiodun , Akinola Mobolaji Oluwapelumi , Adegun Wuraola Olamide , Akinwunmi Esther Olutosin, , Omoseyin Tunmise Micheal 
Published: June 2023

Abstract
The ban on antibiotics across the globe necessitated the need for an alternative in the production and management of animal health, and this made herbal medicines like Lagenaria breviflora validated to be an alternative. Two hundred and eight (208) day‑old Cobb 500 chickens were randomly assigned to four (4) treatment groups of Lagenaria breviflora: control (0g), 50, 100, and 150 grams per litre, with fifty‑two (52) birds each, having thirteen (13) birds per four (4) replicates. The meat was excised from the breast region of slaughtered birds on the 49th day of the experiment and evaluated for meat technological quality, oxidative stability, and sensorial profile. The data generated were evaluated using the One‑way analysis of variance (ANOVA). The highest water absorption capacity (WAC) (61.50%) and water holding capacity (WHC) (51.09%) were observed in groups 150 g Lb and 100 g Lb, respectively. Administration of 50 g and 150 g aqueous extract of Lagenaria breviflora affected (p < 0.05) the intrinsic a* (redness) meat colour but had no significant effect (p > 0.05) on its L* (lightness) and b* (yellowness). The data showed that administration of Lagenaria breviflora had no effect (p > 0.05) on the sensory profile of the breast meat. Glutathione peroxidase (1.85U/L) (p < 0.05) was highest and similar in the control and 150 g Lb group. In conclusion, to ensure improved meat quality and oxidative stability of meat from broiler chickens, the administration of aqueous Lagenaria breviflora at 150 g per litre of water is recommended.
Construyendo una democracia más sustantiva e integral en ecuador: ¿y si aprendemos de la democracia comunitaria?
Authors: Madrid Andrea 
Published: June 2023

El sistema de partidos políticos ha sido uno de los mecanismos de la democracia representativa para incluir la diversidad social. No obstante, bajo esta forma hegemónica de organización política han sido opacadas otras lógicas de relacionamiento surgidas de esquemas culturales diferentes. En este contexto, en 2008, la democracia comunitaria fue reconocida constitucionalmente en Ecuador, al mismo nivel que la representativa y la directa. A partir de eso, el reto a nivel país ha sido legitimar este mecanismo comunitario de ejercer la democracia, como ocurre con los otros. El objetivo del presente artículo es, por un lado, analizar cómo la democracia representativa integra “lo diferente” bajo el sistema de partidos, reflexionando sobre el cambio de paradigma que supuso el reconocimiento de las formas culturalmente diversas de democracias. Por otro lado, se analiza la democracia comunitaria, en la que se observan coincidencias con los planteamientos de la democracia sustantiva e integral.
va e integral.
Relativistic Symmetries of Bosonic Particles and Antiparticles in the Background of the Position-Dependent Mass for the Improved Deformed Hulthen Plus Deformed Type-Hyperbolic Potential in 3D-EQM Symmetries
Authors: Maireche Abdelmadjid 
Published: June 2023

The bound state solutions of the deformed Klien-Gordon equation have been determined in the three-dimensional extended relativistic quantum mechanics 3D-ERQM symmetries using position-dependent mass (PDM) with unequal scalar and vector potential for the improved Hulthén plus improved deformed type-hyperbolic potential (PDM-SVID(H-TP)) models. PDM with unequal scalar and vector potential for the Hulthén plus deformed type-hyperbolic potential (PDM-(SVH-DTP)) models, as well as a combination of radial terms, which are coupled with the coupling LΘ, which explains the interaction of the physical features of the system with the topological deformations of space-space. The new relativistic energy eigenvalues have been derived using the parametric Bopp shift method and standard perturbation theory which is sensitive to the atomic quantum numbers (j,l,s,m), mixed potential depths (V0S0V1S1), the rest, and perturbed mass (m0,m1), the screening parameter's inverse α, and noncommutativity parameters (Θ,τ,χ). Within the framework of 3D-ERQM symmetries, we have treated certain significant particular instances that we hope will be valuable to the specialized researcher. We have also treated the nonrelativistic limit and applied our obtained results to generate the mass spectra of heavy-light mesons (HLM) such as cc- and bb- under PDM-SE with improved deformed Hulthén plus improved hyperbolic potential (PDM‑ID(H-TP)) models. When the three simultaneous limits (Θ,τ,χ) were applied, we recovered the normal results of relativistic in the literature ( 0,0,0) for the PDM‑ID(H-TP)) models.
Analisis Hubungan Antara Sikap dan Prestasi Belajar Kuliah Online pada Mata Kuliah Pemisahan Analitik Mahasiswa Pendidikan Kimia FKIP Universitas Mataram
Authors: Anam Muhammad Khaerul , Burhanuddin Burhanuddin , Hadisaputra Saprizal , Muntari Muntari 
Published: June 2023

Penelitian ini bertujuan untuk mendeskripsikan hubungan antara sikap dan prestasi belajar kuliah online pada mata kuliah pemisahan analitik mahasiswa Pendidikan Kimia FKIP di Universitas Mataram. Jenis penelitian ini merupakan penelitian deskriptif dengan pendekatan kuantitatif. Populasi penelitian sebanyak 75 mahasiswa dengan dibagi menjadi 3 kelas yaitu kelas A, B, dan C, sedangkan sampelnya adalah sebanyak 19 dengan menggunakan rumus Slovin dari mahasiswa kelas B dan C yang diambil secara acak. Pengumpulan data menggunakan instrumen angket sikap belajar dan dokumentasi prestasi belajar kuliah online. Teknik analisis data menggunakan statistik inferensial. Hasil penelitian uji hipotesis menggunakan korelasi Pearson Product Moment menunjukan nilai koefisien korelasi antara variabel sikap belajar dan prestasi belajar kuliah online sebesar 0,20; koefisien determinasi = 4%; dan thitung = 0,71 < ttabel= 1,729. Hasil uji persentase yang di peroleh yaitu untuk sikap belajar sebesar 63% dengan rincian yaitu besarnya pengaruh sikap mahasiswa dari aspek kognitif 64,91% mahasiswa mempunyai sikap yang tinggi dan 35,09% mahasiswa mempunyai sikap yang rendah. Besarnya pengaruh sikap mahasiswa dari aspek afektif 65,19% mahasiswa mempunyai sikap yang tinggi dan 34,81% mahasiswa mepunyai sikap yang rendah. Besarnya pengaruh sikap dari aspek konatif 65,04% mahasiswa mempunyai sikap yang tinggi dan 34,96% mahasiswa yang mempunyai sikap yang rendah, sedangkan persentase untuk prestasi belajar sebesar 97% dengan rincian untuk kategori prestasi tinggi sebesar P = 88% sedangkan untuk kategori prestasi rendah sebesar P = 12%. Berdasarkan hasil tersebut dapat disimpulkan bahwa terdapat hubungan yang positif dan signifikan antara sikap dan prestasi belajar kuliah online pada mahasiswa dengan tingkat korelasi rendah.
Peace Efforts in the Divorce Cases: An Analysis on Verstek's Decision at the Religious Courts
Authors: Sudirman L Sudirman L , Bahri S Andi , Faisal Ahmad , Lahaji  
Published: June 2023

Indonesian national legal regulations requires judges to seek reconciliation between the parties effectively and optimally in each trial to prevent a divorce. However, in reality practice, these efforts have not been carried out optimally, so that some divorce cases increased from time to time in particular of verstek decisions, especially verstek decisions. This study aims to determine the implementation of peace efforts in divorce cases at the Parepare Religious Court, and to uncover the causes of non-achievement peace efforts so that a panel of judges decides in a verstek manner. This research applied empirical juridical method. The results of the study shows that the implementation of peace efforts at the Parepare Religious Court has not been effective and optimal in preventing divorce cases, especially in verstek case due to the judge's performance has not been maximized in seeking peace for every trial. In addition, the absence of one party with the intention to facilitate the divorce process as well as the desire of the parties to divorce has conducted a peace more difficult to achieve, in the end the judge set a verstek divorce decision.
Phytochemical profiling, antimicrobial and anticancer potential of Rosmarinus officinalis growing in Kashmir Himalayan region
Authors: Theyyathel AM , Sofi Mohmmad Ashaq , Nanda Anima , Sofi Mohd Abass , Parray Rasik , Sheikh Touseef , Shah Manzoor Ahmad 
Published: June 2023

Currently, medicinal plants are gaining importance in pharmaceutical and scientific communities. Medicinal plants are the most abundant natural source of valuable phytochemicals, which can help treat human diseases. The present study aimed to do phytochemical profiling and assess the antimicrobial and anticancer activity of the methanolic leaf extract of Rosmarinus officinalis. The photochemical profiling of R. officinalis leaves was done by GC-MS analysis. Twenty-six compounds were identified from the leaf extracts with great significance in pharmaceutical science for therapeutically efficient formulations to combat various diseases. The antimicrobial activity was done by the well diffusion method, while the anticancer potential against the A549 lung cancer cell line by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The highest zone of inhibition was seen against Escherichia coli ATCC 11229 (21 ± 0.7 mm), Enterococcus faecalis ATCC 29212 (19 ± 0.8 mm), Candida albicans ATCC 10231 (18± 0.6 mm) followed by Staphylococcus aureus ATCC 25923 (18 ± 0.8 mm) and Pseudomonas aeruginosa (11 ± 0.5 mm) with MIC values ranging from 128 to 256 µg/mL. R. officinalis demonstrated significant (p ≤ 0.05) anticancer activity against the A549 cancer cell line with IC50 values of 39.70 and 33.60 µg/mL for 24 and 48 hours, respectively. The methanolic extract of R. officinalis can be a potential antimicrobial and anticancer agent and a vital resource for developing new drugs.
Quality assessment of value-added Indian recipe pedakiya prepared from composite flour and sesame seeds.
Authors: Garg Meenakshi , Suraj Rahul Kumar , Sachdeva Shallu , Mathew Sharon Rose , Agarwal Aparna 
Published: June 2023

The present study was designed to enhance the nutritional value of the Indian recipe pedakiya/gujiya, a traditional sweet deep-fried dumpling, by utilizing the beneficial properties of composite flour (oat and peas flour) and sesame seeds. Furthermore, the study aimed to investigate the effects of partial substitution of refined wheat flour with oat and peas flour on nutritional, sensory, and microbiological parameters as affected by different cooking (deep-fat frying, baking, and air-frying) methods. The dough was developed by partially substituting a high percentage of refined wheat flour with oat flour, peas flour, and sesame seeds and based on the different treatments, these were coded as P0 (control), P1 (value-added pedakiya processed by deep-fat frying at 120 °C /5 minutes), P2 (air-fried at 120 °C /30 minutes), and P3 (baked at 200 °C /25 minutes). Based on sensory evaluation, sample P1 was the most acceptable by the sensory panel. Chemical analyses revealed that the addition of composite flour and sesame seeds substantially increased the nutritional parameters of the product. The product's microbiological analyses revealed that, up to a 15-day storage period, the product was well within safe levels. Aluminum bags were determined to be a suitable packaging material for storing the value-added pedakiya based on the water activity (at 37 °C/91% RH) and overall acceptability scores. This study has provided an alternative approach for preparing traditional pedakiya by utilizing healthier options. The topic of the present study is very timely since consumers are constantly looking for better alternatives to traditional fried dishes.
Heave Behavior of Granular Pile Anchor-Foundation System (GPA-Foundation System) in Expansive Soil
Authors: Aljorany Ala Nasir , Ibrahim Saad Farhan , Al-Adly Ahmed Ibrahim 
Published: June 2023

Granular Pile Anchor (GPA) is one of the innovative foundation techniques, devised for mitigating heave of footing resulting from the expansive soils. This research attempts to study the heave behavior of (GPA-Foundation System) in expansive soil. Laboratory tests have been conducted on an experimental model in addition to a series of numerical modeling and analysis using the finite element package PLAXIS software. The effects of different parameters, such as (GPA) length (L) and diameter (D), footing diameter (B), expansive clay layer thickness (H) and presence of non-expansive clay are studied. The results proved the efficiency of (GPA) in reducing the heave of expansive soil and showed that the heave can be reduced with increasing length and diameter of (GPA). The heave of (GPA-Foundation System) is controlled by three independent variables these are (L/D) ratio, (L/H) ratio and (B/D) ratio. The heave can be reduced by up to (38 %) when (GPA) is embedded in expansive soil layer at (L/H=1) and reduced by about (90 %) when (GPA) is embedded in expansive soil and extended to non- expansive clay (stable zone) at (L/H=2) at the same diameter of (GPA) and footing. An equation (mathematical mode1) was obtained by using the computer package (SPSS 17.0) for statistical analysis based on the results of finite element analysis relating the maximum heave of (GPA-Foundation System) as a function of the above mentioned three independent variables with coefficient of regression of (R2 = 92.3 %).
Mixed Convection in a Square Cavity Filled with Porous Medium with Bottom Wall Periodic Boundary Condition
Authors: Hussein Ihsan Y. , Ali Luma F. 
Published: June 2023

Transient mixed convection heat transfer in a confined porous medium heated at periodic sinusoidal heat flux is investigated numerically in the present paper. The Poisson-type pressure equation, resulted from the substituting of the momentum Darcy equation in the continuity equation, was discretized by using finite volume technique. The energy equation was solved by a fully implicit control volume-based finite difference formulation for the diffusion terms with the use of the quadratic upstream interpolation for convective kinetics scheme to discretize the convective terms and the temperature values at the control volume faces. The numerical study covers a range of the hydrostatic pressure sinusoidal amplitude range and time period values of . Numerical results show that the pressure contours lines are influenced by hydrostatic head variation and not affected with the sinusoidal amplitude and time period variation. It is found that the average Nusselt number decreases with time and pressure head increasing and decreases periodically with time and amplitude increasing. The time averaged Nusselt number decreases with imposed sinusoidal amplitude and cycle time period increasing.