bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foamwork: Challenges and strategies in using mineral foam 3D printing for a lightweight composite concrete slab
Authors: Bedarf Patrick , Szabo Anna , Scoccimarro Enrico , Dillenburger Benjamin 
Published: May 2023

This paper presents an innovative design and fabrication workflow for a lightweight composite slab prototype that combines mineral foam 3D printing (F3DP) and concrete casting. Non-standardized concrete elements that are geometrically optimized for resource efficiency often result in complex shapes that are difficult to manufacture. This paper extends the research in earlier studies, showing that F3DP can address this challenge. F3DP is used to construct 24 stay-in-place formwork elements for a lightweight, resource-efficient ribbed concrete element with a 2 × 1.3 m footprint. This advancement highlights the improved robotic F3DP setup, computational design techniques for geometry and print path generation, and strategies to achieve near-net-shape fabrication. The resulting prototype shows how complex geometries that were previously cost-prohibitive can be produced efficiently. Discussing the findings, challenges, and future improvements offers useful perspectives and supports the development of this resourceful and sustainable construction technique.
Implications for Practice: How to Write a Meaningful Contribution
Authors: Kroese Ingeborg 
Published: May 2023

Problem There is a continued, well documented disconnect between HRD scholars and practitioners. Specifically, the ‘Implications for HRD Practice’ section in academic articles is often lacking in relevance and meaning. This is harmful for both academia and practice, but especially for the well-being of learners. Solution This essay focusses on how to write a meaningful ‘Implications for HRD Practice’ section and suggests five areas to consider: why writing for practice is important; understand who practice is; relate to practitioners’ knowledge; provide evidence-based suggestions and finally, connect with practice. Stakeholders HRD scholars who are committed to write for, and connect with, practice.
Designing for Hope: Biophilic Color Associations and Their Relevance to Clinical Settings
Authors: Edwards Thomas Mark 
Published: May 2023

Aim: To consider one common aspect of biophilic design (BD; i.e., color) and its relationship to an important element of well-being (i.e., hope). Background: BD is multifaceted making the identification of critical design elements difficult. Further complexity is introduced given that practice assumptions stemming from the biophilia hypothesis may be questioned. Consistent with the biophilia hypothesis, the author considers the study’s findings from the perspectives of evolutionary psychology and psychobiology. Methods: One hundred and fifty four adult participants engaged in one of the three experiments. Using colored test cards, Experiment #1 sought to determine which of four biophilic colors (i.e., red, yellow, green, or blue) evoked the strongest experience of hope. Considering this color alone, Experiment #2 sought to manipulate “color depth.” Participants were asked to identify what color depth evoked the strongest experience of hope. Experiment #3 sought to determine if the outcomes of Experiments #1 and #2 were due to a priming effect. All participants were asked about color associations they held. Results: Experiments #1 and #2 demonstrated that yellow at maximal color depth evoked the strongest experience of hope ( p < .001). Experiment #3 demonstrated that no priming effect was evident ( p < .05). No participant had a strong personal preference for/against yellow. Natural world color associations existed for yellow, green, and blue. Red held emotive associations. Conclusions: These findings clearly associate yellow with hope. From the perspectives of evolutionary psychology and psychobiology this suggests color cues can evoke time-dependent motive states. Implications for practitioners designing spaces of hope within healthcare facilities are considered.
Safety Profile of High-Dose Intravenous Push Lacosamide
Authors: Torian Sterling C. , Jones G. Morgan 
Published: May 2023

Lacosamide (LCM) is an antiseizure medication used to manage status epilepticus (SE). Previous retrospective analyses have demonstrated safety and efficiency in intravenous push (IVP) administration at 80 mg per minute. Quick administration can be achieved in a high-acuity setting without the additional time required for compounding. However, previous literature only partially represents high doses of IVP LCM, which limits the understanding of the safety profile of these doses. Our study was a single-center, retrospective, single-arm analysis of patients who received IVP LCM 300 mg or 400 mg during admission. The primary outcome was the incidence of infusion site reactions, hypotension, and bradycardia within 2 hours of IVP administration. Secondary outcomes included the incidence of PR prolongation. A total of 113 patients were evaluated for infusion site reactions. Of these, 108 patients had vital signs assessed within 2 hours of IVP LCM and could be evaluated for hypotension and bradycardia. The sample primarily consisted of LCM 400 mg IVP (85.8%). The primary outcome consisted of 7 (6.2%) infusion reactions, 12 (11.1%) hypotensive events, and no reports of bradycardia. Each adverse event was assessed using the Naranjo Adverse Drug Probability Scale. All events scored less than two, suggesting the possibility was likely related to factors other than the medication. In conclusion, LCM 300 mg and 400 mg IVP administration have the potential to facilitate more rapid treatment of seizures without additional risk of infusion site reactions, hypotension, and bradycardia.
Specifics of Public Administration in Countries With a Developed Energy Sector: The Case Study
Authors: Bashina Olga E. , Simonova Marina D. , Matraeva Lilia V. , Mamiy Irina P. , Korolkova Nataliya A. 
Published: May 2023

Countries with a large energy sector are faced with the issues of forming and developing a state energy policy that takes into account not only sectoral and intersectoral aspects, but also the components of managing significant amounts of rental income. In this regard, any of these economic systems, on the one hand, has great opportunities associated with the management of energy resources as a factor of development, on the other hand, it is constantly at risk of destabilization of the economic system as a whole. To date, the economic history allows us to speak about the accumulation of a sufficient number of observations for conducting a comprehensive study of the features of the development of public energy policies. The study is based on the formalization of historical descriptions of the experience of 24 countries (30 cases). The article describes in detail the experience of 13 of the most striking cases. This made it possible to identify 14 variables for evaluating the state energy policy, while outlining three areas (areas of attention) of public administration. The choice of variables used in the model was made on the basis of the relative frequencies of the mechanism application for the observed population, MNRW-TF recommendations within the improving extractive industry, the formation of the contribution of resource industries to the socio-economic development of the country and etc. Further cluster analysis led to the identification of both a pronounced polarity in the development of the state energy policy and options for combining its areas. JEL Classifications: C82, Q43, Q48, P51, O57, O11.
Bone Cement Reperfusion Revision Surgery for Symptomatic Recurrence of Kümmell’s Disease After Percutaneous Kyphoplasty
Authors: Chen Tangyiheng , Lin Cheng , Wang Yujie , Yang Huilin , Li Xuefeng , Chu Genglei , Jiang Weimin , Liu Yijie 
Published: May 2023

Study Design Retrospective study. Objectives To demonstrate that repeat Percutaneous vertebroplasty (PVP) performed for the same cemented vertebrae in Kümmell’s disease can offer therapeutic benefit for patients with recurrent symptoms after initial percutaneous kyphoplasty (PKP) treatment. Methods From January 2019 to December 2021, we investigated 2932 patients with PKP. Among them, 191 patients were diagnosed Kümmell’s disease. 33 patients upon presentation of recurrent symptoms underwent repeat PVP procedure. Radiologic outcomes and clinic indices were investigated. Results Bone cement reperfusion surgery was successfully completed in 33 patients. The average age was 73.5 ± 8.2 years old. The kyphosis angle showed significant correction from pre-operation to the final follow-up, descending from pre-operation (20.6 ± 11.1°) to final follow-up (15.4 ± 7.9°). The vertebral heights at different follow-up appointments were significantly higher than the pre-operative appointments. The VAS and ODI scores at final follow-up were respectively 1.2 ± .8 and 27.3 ± 5.4%, which were both significantly lower than those before operation. No complications such as cement leakage into the spinal canal or cement displacement occurred during follow-up. Conclusions Bone cement reperfusion surgery can ameliorate kyphosis and restore vertebral height to some extent. Repeat PVP is a minimally invasive surgery that provides superior long-term results in clinical and radiological outcomes but is technically more difficult to perform.
Corporate Social Responsibility and Sustainability of Corporate Performance
Authors: Dhingra Kanika 
Published: May 2023

A firm has a prospect to surge its assistance for the social order in an interchange of improved repute and development in industry, which finally hints at sturdy fiscal functioning and high productivity. Corporate sustainability is resultant from the perception of sustainable development. It fundamentally mentions toward the part, which corporations can show in gathering the schema of sustainable expansion and necessitates a steady line to financial development, societal evolution, and ecological stewardship. Corporate Social Responsibility (CSR) in India emphasizes on anything that ended with returns after they are completed. On the other side, sustainability concerns factoring the societal and ecological influences of directing industry, that is, how revenues are created. Henceforth, ample of the Indian exercise of CSR occurs as a significant constituent of sustainability or accountable industry, which is a greater clue, a statistic obvious from numerous sustainability contexts. The readings on the relationship between CSR and Sustainability by means of monetary functioning include fundamentally two types. The first practices procedure of studying the events to measure the short-run monetary effect (abnormal returns) when organizations involve in their publicly accountable or negligent deeds. The second observes the association among the certain degree of corporate social functioning and variables of long-term financial functioning by using accounting or financial measures of profitability. The objectives of the report are to analyse the impression of CSR proposals of a company on its financial performance, its net profit, and total resources (assets). The data study is done with Statistical Package for the Social Sciences (SPSS) software and statistical tools such as correlation and regression are used. The correlation coefficient (a value between −1 and +1) states how sturdily two variables are associated with each other. The regression analysis is a statistical procedure used to estimate the consequences of independent variables on a particular dependent variable. After the analysis, it can be concluded that the CSR is positively correlated with the firm’s PAT (profit after tax) and firm’s total resources (assets) and since the significance value is less than 5% in both the cases of regression (CSR with PAT; PAT and CSR with total assets), therefore it is concluded that CSR acts as a major factor and certain additional factors are also answerable for the transformations in the PAT: profit after tax and total assets of the company.
Retrospective Cohort Study Comparing Antiretroviral Treatment Outcomes Among Adolescents in Teen Clubs and Standard Care Clinics: Blantyre, Malawi
Authors: Alibi Michael , Mwapasa Victor , Ngwalangwa Fatsani 
Published: May 2023

Introduction This study investigated if the Teen Club model improves virological suppression and reduces virological failure. Viral load monitoring is a golden ART programme performance indicator. HIV treatment outcomes are poor among adolescents compared to adults. Different service delivery models are being implemented to address this; among them is the Teen Club model. Currently, teen clubs improve treatment adherence (short-term impact), but there is a knowledge gap regarding the long-term impact. The study compared the rate of virological suppression and failure among adolescents in Teen Clubs and those on the standard of care (SoC) model. Methods This was a retrospective cohort study. A total of 110 adolescents in teen clubs and 123 adolescents in SOC from six health facilities were selected using stratified simple random sampling. The participants were followed for 24 months. STATA version 16.0 was used for data analysis. Univariate analyses were performed for both demographic and clinical variables. A Chi-squared test was used to assess the differences between proportions. Crude and adjusted relative risks were calculated using a binomial regression model. Results At 24 months, 56% of adolescents in the SoC arm had viral load suppression compared to 90% in the Teen Club arm. Of those who achieved viral load suppression at 24 months, about 22.7% (SoC) and 76.4% (Teen Club) achieved undetectable viral load suppression rates. Adolescents in the Teen Club arm had a lower viral load than those in the SoC arm (adjusted RR 0.23, 95% CI: 0.11-0.61; p  =  0.002 adjusted for age and gender). Teen Club and SoC adolescents had virological failure rates of 3.1% and 10.9%, respectively. The adjusted RR was 0.16, 95% CI: 0.03-0.78; p  =  0.023; those in Teen Clubs were less likely to have virological failure relative to those in SoC after adjusting for age, sex, and place of residence. Conclusion The study found that Teen Club models are more effective at achieving virological suppression among HIV positive adolescents.
Superior Capsular Reconstruction Versus Latissimus Dorsi Tendon Transfer for Irreparable Rotator Cuff Tears: Minimum 5-year Outcomes
Authors: Hanson Jared A. , Lee Simon , Horan Marilee P. , Rakowski Dylan R. , Millett Peter J. 
Published: May 2023

Background: Arthroscopic superior capsular reconstruction (SCR) has been introduced as a successful alternative to latissimus dorsi tendon transfer (LDTT) for irreparable posterosuperior rotator cuff tears. Purpose: To compare minimum 5-year clinical outcomes of SCR and LDTT for the treatment of irreparable posterosuperior rotator cuff tears in patients with minimal evidence of arthritis and intact or reparable subscapularis tears. Study Design: Cohort study; Level of evidence, 3. Methods: Patients who underwent SCR or LDTT and had undergone surgery ≥5 years earlier were included. The SCR technique used a dermal allograft customized to the defect. Surgical, demographic, and subjective data were collected prospectively and reviewed retrospectively. Patient-reported outcome (PRO) scores utilized were the American Shoulder and Elbow Surgeons (ASES), Single Assessment Numeric Evaluation (SANE), the short version of the Disabilities of the Arm, Shoulder and Hand score (QuickDASH), 12-Item Short Form Health Survey Physical Component Summary (SF-12 PCS), and patient satisfaction. Further surgical procedures were documented, and treatment that progressed to reverse total shoulder arthroplasty (RTSA) or revision rotator cuff surgery was considered a failure. Kaplan-Meier survivorship analysis was performed. Results: Thirty patients (n = 20 men; n = 10 women) with a mean follow-up of 6.3 years (range, 5-10.5 years) were included. A total of 13 patients underwent SCR and 17 patients underwent LDTT. The mean age of the SCR group was 56 years (range, 41.2-63.9 years), and the mean age of the LDTT group was 49 years (range, 34.7-57 years) ( P = .006). One patient in the SCR group and 2 patients in the LDTT group progressed to RTSA. Two additional (11.8%) patients in the LDTT group had further surgery—1 had arthroscopic cuff repair and 1 had hardware removal with biopsies. The SCR group demonstrated significantly better ASES (94.1 ± 6.3 vs 72.3 ± 16.4; P = .001), SANE (85.6 ± 8 vs 48.7 ± 19.4; P = .001), QuickDASH (8.8 ± 8.7 vs 24.3 ± 16.5; P = .012), and SF-12 PCS (56.1 ± 2.3 vs 46.5 ± 6; P = .001) PROs at the final follow-up. There was no significant difference between groups in median satisfaction (SCR, 9; LDTT, 8 [ P = .379]). At 5 years, survivorship rates were 91.7% and 81.3% for the SCR and LDTT groups, respectively ( P = .421). Conclusion: At the final follow-up, SCR yielded superior PROs compared with LDTT for the treatment of massive, irreparable posterosuperior rotator cuff tears despite similar patient satisfaction and survivorship between procedures.
CAR NK-92 cell–mediated depletion of residual TCR+ cells for ultrapure allogeneic TCR-deleted CAR T-cell products
Authors: Kath Jonas , Du Weijie , Martini Stefania , Elsallab Magdi , Franke Clemens , Hartmann Laura , Drosdek Vanessa , Glaser Viktor , Stein Maik , Schmueck-Henneresse Michael , Reinke Petra , Volk Hans-Dieter , Abou-el-Enein Mohamed , Wagner Dimitrios L. 
Published: May 2023

Abstract
Graft-versus-host disease (GVHD) is a major risk of the administration of allogeneic chimeric antigen receptor (CAR)-redirected T cells to patients who are HLA unmatched. Gene editing can be used to disrupt potentially alloreactive T-cell receptors (TCRs) in CAR T cells and reduce the risk of GVHD. Despite the high knockout rates achieved with the optimized methods, a subsequent purification step is necessary to obtain a safe allogeneic product. To date, magnetic cell separation (MACS) has been the gold standard for purifying TCRα/β– CAR T cells, but product purity can still be insufficient to prevent GVHD. We developed a novel and highly efficient approach to eliminate residual TCR/CD3+ T cells after TCRα constant (TRAC) gene editing by adding a genetically modified CD3-specific CAR NK-92 cell line during ex vivo expansion. Two consecutive cocultures with irradiated, short-lived, CAR NK-92 cells allowed for the production of TCR– CAR T cells with &lt;0.01% TCR+ T cells, marking a 45-fold reduction of TCR+ cells compared with MACS purification. Through an NK-92 cell–mediated feeder effect and circumventing MACS-associated cell loss, our approach increased the total TCR– CAR T-cell yield approximately threefold while retaining cytotoxic activity and a favorable T-cell phenotype. Scaling in a semiclosed G-Rex bioreactor device provides a proof-of-principle for large-batch manufacturing, allowing for an improved cost-per-dose ratio. Overall, this cell-mediated purification method has the potential to advance the production process of safe off-the-shelf CAR T cells for clinical applications.
Treatment of thrombocytopenia and thrombosis in HIT in mice using deglycosylated KKO: a novel therapeutic?
Authors: Sarkar Amrita , Khandelwal Sanjay , Koma Gavin T. , Kim Hyunjun , Gruel Yves , Rollin Jerome , Passam Freda , Wool Geoffrey D. , Arepally Gowthami M. , Cines Douglas B. , Rauova Lubica , Poncz Mortimer 
Published: May 2023

Abstract
Heparin-induced thrombocytopenia (HIT) is characterized by thrombocytopenia associated with a highly prothrombotic state due to the development of pathogenic antibodies that recognize human platelet factor 4 (hPF4) complexed with various polyanions. Although nonheparin anticoagulants are the mainstay of care in HIT, subsequent bleeding may develop, and the risk of developing new thromboembolic events remain. We previously described a mouse immunoglobulin G2bκ (IgG2bκ) antibody KKO that mimics the sentinel features of pathogenic HIT antibodies, including binding to the same neoepitope on hPF4–polyanion complexes. KKO, like HIT IgGs, activates platelets through FcγRIIA and induces complement activation. We then questioned whether Fc-modified KKO could be used as a novel therapeutic to prevent or treat HIT. Using the endoglycosidase EndoS, we created deglycosylated KKO (DGKKO). Although DGKKO retained binding to PF4–polyanion complexes, it inhibited FcγRIIA-dependent activation of PF4-treated platelets triggered by unmodified KKO, 5B9 (another HIT-like monoclonal antibody), and IgGs isolated from patients with HIT. DGKKO also decreased complement activation and deposition of C3c on platelets. Unlike the anticoagulant fondaparinux, injection of DGKKO into HIT mice lacking mouse PF4, but transgenic for hPF4 and FcγRIIA, prevented and reversed thrombocytopenia when injected before or after unmodified KKO, 5B9, or HIT IgG. DGKKO also reversed antibody-induced thrombus growth in HIT mice. In contrast, DGKKO was ineffective in preventing thrombosis induced by IgG from patients with the HIT-related anti-PF4 prothrombotic disorder, vaccine-induced immune thrombotic thrombocytopenia. Thus, DGKKO may represent a new class of therapeutics for targeted treatment of patients with HIT.
Diffuse large B-cell lymphomas have spatially defined, tumor immune microenvironments revealed by high-parameter imaging
Authors: Wright Kyle T. , Weirather Jason L. , Jiang Sizun , Kao Katrina Z. , Sigal Yari , Giobbie-Hurder Anita , Shipp Margaret A. , Rodig Scott J. 
Published: May 2023

Abstract
Diffuse large B-cell lymphoma (DLBCL) not otherwise specified is the most common aggressive non-Hodgkin lymphoma and a biologically heterogeneous disease. Despite the development of effective immunotherapies, the organization of the DLBCL tumor-immune microenvironment (TIME) remains poorly understood.We interrogated the intact TIME of 51 de novo DLBCLs with triplicate sampling to characterize 337 995 tumor and immune cells using a 27-plex antibody panel that captured cell lineage, architectural, and functional markers. We spatially assigned individual cells, identified local cell neighborhoods, and established their topographical organization in situ. We found that the organization of local tumor and immune cells can be modeled by 6 composite cell neighborhood types (CNTs). Differential CNT representation divided cases into 3 aggregate TIME categories: immune-deficient, dendritic cell–enriched (DC-enriched), and macrophage-enriched (Mac-enriched). Cases with immune-deficient TIMEs have tumor cell–rich CNTs, in which the few infiltrating immune cells are enriched near CD31+ vessels, in keeping with limited immune activity. Cases with DC-enriched TIMEs selectively include tumor cell–poor/immune cell–rich CNTs with high numbers of CD11c+ DCs and antigen-experienced T cells also enriched near CD31+ vessels, in keeping with increased immune activity. Cases with Mac-enriched TIMEs selectively include tumor cell–poor/immune cell–rich CNTs with high numbers of CD163+ macrophages and CD8 T cells throughout the microenvironment, accompanied by increased IDO-1 and LAG-3 and decreased HLA-DR expression and genetic signatures in keeping with immune evasion. Our findings reveal that the heterogenous cellular components of DLBCL are not randomly distributed but organized into CNTs that define aggregate TIMEs with distinct cellular, spatial, and functional features.