bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forward $$\gamma $$+jet production in proton-proton and proton-lead collisions at LHC within the FoCal calorimeter acceptance
Authors: Ganguli Ishita , Hameren Andreas van , Kotko Piotr , Kutak Krzysztof 
Published: September 2023

AbstractUsing the small-x improved transverse momentum dependent factorization (ITMD), which, for a general two-to-two massless scattering can be proved within the color glass condensate (CGC) theory for transverse momenta of particles greater than the saturation scale, we provide predictions for isolated forward photon and jet production in proton-proton and proton-nucleus collisions within the planned ALICE FoCal detector acceptance. We study azimuthal correlations, $$p_T$$

p
T

spectra, as well as normalized ratios of proton-proton cross sections for different energies. The only TMD distribution needed for that process is the “dipole” TMD gluon distribution, which in our computations is based on HERA data and undergoes momentum space BK evolution equation with DGLAP corrections and Sudakov resummation. We conclude, that the process provides an excellent probe of the dipole TMD gluon distribution in saturation regime.
A tilt instability in the cosmological principle
Authors: Krishnan Chethan , Mondol Ranjini , Sheikh-Jabbari M. M. 
Published: September 2023

AbstractWe show that the Friedmann–Lemaître–Robertson–Walker (FLRW) framework has an instability towards the growth of fluid flow anisotropies, even if the Universe is accelerating. This flow (tilt) instability in the matter sector is invisible to Cosmic No-Hair Theorem-like arguments, which typically only flag shear anisotropies in the metric. We illustrate our claims in the setting of “dipole cosmology”, the maximally Copernican generalization of FLRW that can accommodate a flow. Simple models are sufficient to show that the cosmic flow need not track the shear, even in the presence of a positive cosmological constant. We also emphasize that the growth of the tilt hair is fairly generic if the effective equation of state$$w \rightarrow -1$$w→-1at late times (as it does in standard cosmology), irrespective of the precise model of dark energy. The generality of our theoretical result puts various recent observational claims about late time anisotropies and cosmic dipoles in a new light.
Water quality of the southern Tibetan Plateau: hydrogeochemical assessment of the Yarlungzangbo River
Authors: Shi Dongping , Tan Hongbing , Zhang Yu , Cong Peixin , Cao Yucheng 
Published: September 2023

The Yarlungzangbo River is the largest river system draining the northern slopes of the Himalayan ranges on the southern Tibetan Plateau and has a crucial role in the supply of water downstream. We investigated the chemical composition of the Yarlungzangbo River and its major tributaries (the Nianchu and Lhasa rivers). Water samples (
n
= 165) were collected and analysed for major ions and trace elements. Multivariable analyses showed that the geology and climate are the major explanatory variables for the spatiotemporal variations of the water chemistry in this river system. The water chemistry is mainly controlled by carbonate weathering, with Ca
2+
and HCO
3
−
as the dominant ions. Another potential ion source affecting the river water chemistry is the discharge from hot springs, which is rich in Na
+
, Cl
−
, SO
4
2−
and Li, resulting in higher solute concentrations in the source region and upstream, with the total dissolved solids reaching 176.9 mg L
−1
. The concentrations of most trace elements are generally low, although elevated concentrations of As (16.6

μ

g L
−1
) and Sb (2.08

μ

g L
−1
) are found in the headwaters and additions from untreated wastewater are evident. These concentrations exceed the national drinking water standard for China and the World Health Organization drinking water guideline, posing a risk to people living in both the local and surrounding areas.

Supplementary material:
The basic field records, water chemical compositions and trace elements of the Yarlungzangbo River and its main tributaries, and concentrations of chemicals of health significance as described by the international guideline (WHO) and the China national guideline (GB) for drinking water quality are available at
https://doi.org/10.6084/m9.figshare.c.6850720
RoboWorld: Verification of Robotic Systems with Environment in the Loop
Authors: Baxter James , Carvalho Gustavo , Cavalcanti Ana , Júnior Francisco Rodrigues 
Published: September 2023

A robot affects and is affected by its environment, so that typically its behaviour depends on properties of that environment. For verification, we need to formalise those properties. Modelling the environment is very challenging, if not impossible, but we can capture assumptions. Here, we present RoboWorld, a domain-specific controlled natural language with a process algebraic semantics that can be used to define (a) operational requirements, and (b) environment interactions of a robot. RoboWorld is part of the RoboStar framework for verification of robotic systems. In this article, we define RoboWorld’s syntax and hybrid semantics, and illustrate its use for capturing operational requirements, for automatic test generation, and for proof. We also present a tool that supports the writing of RoboWorld documents. Since RoboWorld is a controlled natural language, it complements the other RoboStar notations in being accessible to roboticists, while at the same time benefitting from a formal semantics to support rigorous verification (via testing and proof).
Hypoxic Bone Marrow Stromal Cells Secrete miR-140–5p and miR-28–3p That Target SPRED1 to Confer Drug Resistance in Multiple Myeloma
Authors: Zhang Hui , Du Zhimin , Tu Chenggong , Zhou Xinyan , Menu Eline , Wang Jinheng 
Published: September 2023

Abstract

Bone marrow stromal cell (BMSC)–derived small extracellular vesicles (sEV) promote drug resistance to bortezomib in multiple myeloma cells. Elucidating the components of BMSC sEV that induce drug resistance in multiple myeloma cells could help identify strategies to overcome resistance. Considering the hypoxic nature of the myeloma microenvironment, we explored the role of hypoxia in regulating BMSC sEV cargo and investigated whether hypoxia-driven sEV miRNAs contribute to the drug resistance in multiple myeloma cells. Hypoxia increased the release of sEVs from BMSCs, and these sEVs more strongly attenuated bortezomib sensitivity in multiple myeloma cells than sEVs from BMSCs under normoxic conditions. RNA sequencing revealed that significantly elevated levels of miR-140–5p and miR-28–3p were enclosed in hypoxic BMSC-derived sEVs. Both miR-140–5p and miR-28–3p conferred bortezomib resistance in multiple myeloma cells by synergistically targeting SPRED1, a member of the Sprouty protein family that regulates MAPK activation. SPRED1 inhibition reduced sensitivity to bortezomib in multiple myeloma cells through activating MAPK-related pathways and significantly promoted multiple myeloma bortezomib resistance and tumor growth in a mouse model. These findings shed light on the role of hypoxia-induced miRNAs shuttled in BMSC-derived sEVs to multiple myeloma cells in inducing drug resistance and identify the miR-140–5p/miR-28–3p/SPRED1/MAPK pathway as a potential targetable axis for treating multiple myeloma.

Significance:
Hypoxia induces stromal cells to secrete extracellular vesicles with increased miR-140–5p and miR-28–3p that are transferred to multiple myeloma cells and drive drug resistance by increasing the MAPK signaling.
Super Enhancer–Regulated LncRNA LINC01089 Induces Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasis
Authors: Su Tao , Zhang Nasha , Wang Teng , Zeng Jiajia , Li Wenwen , Han Linyu , Yang Ming 
Published: September 2023

Abstract

Hepatocellular carcinoma (HCC) is one of the most lethal neoplasms and has a 5-year survival rate of only 18% in patients with metastatic diseases. Epigenetic modifiers and alterations, including histone modifications, long noncoding RNAs (lncRNA), RNA alternative splicing, and N6-methyladenosine (m6A) modification, are key regulators of HCC development, highlighting the importance of understanding the cross-talk between these biological processes. In the current study, we identified LINC01089 as a super enhancer (SE)–driven lncRNA that promotes epithelial–mesenchymal transition (EMT), migration, invasion, and metastasis of HCC cells in vivo and in vitro. The transcription factor E2F1 bound to a LINC01089 SE, promoting LINC01089 transcription and overexpression. LINC01089 interacted with heterogeneous nuclear ribonucleoprotein M (hnRNPM) and led to hnRNPM-mediated skipping of DIAPH3 exon 3. Knockdown of LINC01089 increased the inclusion of DIAPH3 exon 3, which contains an important m6A-modification site that is recognized by IGF2BP3 to increase DIAPH3 mRNA stability. Thus, LINC01089 loss increased DIAPH3 protein levels, which suppressed the ERK/Elk1/Snail axis and inhibited EMT of HCC cells. In conclusion, this study revealed cross-talk between different epigenetics modifiers and alterations that drives HCC progression and identified LINC01089 as a potential prognostic marker and therapeutic target for HCC.

Significance:
LINC01089 is a super enhancer–driven long noncoding RNA that induces ERK signaling and epithelial–mesenchymal transition by regulating DIAPH3 alternative splicing that blocks N6-methyladenosine–mediated mRNA stabilization, establishing an epigenetic network that promotes hepatocellular carcinoma metastasis.
Long-Read Sequencing Reveals Alternative Splicing-Driven, Shared Immunogenic Neoepitopes Regardless of SF3B1 Status in Uveal Melanoma
Authors: Yao Tengteng , Zhang Zhe , Li Qian , Huang Rui , Hong Yanhong , Li Chen , Zhang Feng , Huang Yingying , Fang Yan , Cao Qin , Jin Xiaoliang , Li Chunliang , Wang Zefeng , Lin Xinhua (James) , Li Lingjie , Wei Wu , Wang Zhaoyang , Shen Jianfeng 
Published: September 2023

Abstract
Tumor-specific neoepitopes are promising targets in cancer immunotherapy. However, the identification of functional tumor-specific neoepitopes remains challenging. In addition to the most common source, single-nucleotide variants (SNV), alternative splicing (AS) represents another rich source of neoepitopes and can be utilized in cancers with low SNVs such as uveal melanoma (UM). UM, the most prevalent adult ocular malignancy, has poor clinical outcomes due to a lack of effective therapies. Recent studies have revealed the promise of harnessing tumor neoepitopes to treat UM. Previous studies have focused on neoepitope targets associated with mutations in splicing factor 3b subunit 1 (SF3B1), a key splicing factor; however, little is known about the neoepitopes that are commonly shared by patients independent of SF3B1 status. To identify the AS-derived neoepitopes regardless of SF3B1 status, we herein used a comprehensive nanopore long-read-sequencing approach to elucidate the landscape of AS and novel isoforms in UM. We also performed high-resolution mass spectrometry to further validate the presence of neoepitope candidates and analyzed their structures using the AlphaFold2 algorithm. We experimentally evaluated the antitumor effects of these neoepitopes and found they induced robust immune responses by stimulating interferon (IFN)γ production and activating T cell–based UM tumor killing. These results provide novel insights into UM-specific neoepitopes independent of SF3B1 and lay the foundation for developing therapies by targeting these actionable neoepitopes.
Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy
Authors: Zhang Huimin , Chen Sanwei , Zhang Yuwei , Tian Chenxi , Pan Jun , Wang Yu , Bai Shiyu , Wu Qielan , Su Miya , Xie Di , Fu Sicheng , Li Shuhang , Zhang Jing , Chen Yusheng , Zhu Shasha , Qian Yeben , Bai Li 
Published: September 2023

Abstract
Dysfunction of intratumoral invariant natural killer T (iNKT) cells hinders their antitumor efficacy, but the underlying mechanisms and the relationship with endogenous antigen priming remain to be explored. Here, we report that antigen priming leads to metabolic reprogramming and epigenetic remodeling, which causes functional reprogramming in iNKT cells, characterized by limited cytokine responses upon restimulation but constitutive high cytotoxicity. Mechanistically, impaired oxidative phosphorylation (OXPHOS) in antigen-primed iNKT cells inhibited T-cell receptor signaling, as well as elevation of glycolysis, upon restimulation via reducing mTORC1 activation, and thus led to impaired cytokine production. However, the metabolic reprogramming in antigen-primed iNKT cells was uncoupled with their enhanced cytotoxicity; instead, epigenetic remodeling explained their high expression of granzymes. Notably, intratumoral iNKT cells shared similar metabolic reprogramming and functional reprogramming with antigen-primed iNKT cells due to endogenous antigen priming in tumors, and thus recovery of OXPHOS in intratumoral iNKT cells by ZLN005 successfully enhanced their antitumor responses. Our study deciphers the influences of antigen priming-induced metabolic reprogramming and epigenetic remodeling on functionality of intratumoral iNKT cells, and proposes a way to enhance efficacy of iNKT cell-based antitumor immunotherapy by targeting cellular metabolism.
Combining Polygenic and Proteomic Risk Scores With Clinical Risk Factors to Improve Performance for Diagnosing Absence of Coronary Artery Disease in Patients With de novo Chest Pain
Authors: Møller Peter Loof , Rohde Palle Duun , Dahl Jonathan Nørtoft , Rasmussen Laust Dupont , Schmidt Samuel Emil , Nissen Louise , McGilligan Victoria , Bentzon Jacob F. , Gudbjartsson Daniel F. , Stefansson Kari , Holm Hilma , Winther Simon , Bøttcher Morten , Nyegaard Mette 
Published: September 2023

Background:
Patients with de novo chest pain, referred for evaluation of possible coronary artery disease (CAD), frequently have an absence of CAD resulting in millions of tests not having any clinical impact. The objective of this study was to investigate whether polygenic risk scores and targeted proteomics improve the prediction of absence of CAD in patients with suspected CAD, when added to the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) minimal risk score (PMRS).

Methods:

Genotyping and targeted plasma proteomics (N=368 proteins) were performed in 1440 patients with symptoms suspected to be caused by CAD undergoing coronary computed tomography angiography. Based on individual genotypes, a polygenic risk score for CAD (PRS
CAD
) was calculated. The prediction was performed using combinations of PRS
CAD
, proteins, and PMRS as features in models using stability selection and machine learning.

Results:

Prediction of absence of CAD yielded an area under the curve of PRS
CAD
-model, 0.64±0.03; proteomic-model, 0.58±0.03; and PMRS model, 0.76±0.02. No significant correlation was found between the genetic and proteomic risk scores (Pearson correlation coefficient, −0.04;
P
=0.13). Optimal predictive ability was achieved by the full model (PRS
CAD
+protein+PMRS) yielding an area under the curve of 0.80±0.02 for absence of CAD, significantly better than the PMRS model alone (
P
<0.001). For reclassification purpose, the full model enabled down-classification of 49% (324 of 661) of the 5% to 15% pretest probability patients and 18% (113 of 611) of >15% pretest probability patients.

Conclusions:
For patients with chest pain and low-intermediate CAD risk, incorporating targeted proteomics and polygenic risk scores into the risk assessment substantially improved the ability to predict the absence of CAD. Genetics and proteomics seem to add complementary information to the clinical risk factors and improve risk stratification in this large patient group.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02264717
From the Outside in: ASMR Is Characterised by Reduced Interoceptive Accuracy but Higher Sensation Seeking
Authors: Poerio Giulia L. , Osman Fatimah , Todd Jennifer , Kaur Jasmeen , Jones Lovell , Cardini Flavia 
Published: September 2023

Abstract
Autonomous Sensory Meridian Response (ASMR) is a complex sensory-perceptual phenomenon characterised by relaxing and pleasurable scalp-tingling sensations. The ASMR trait is nonuniversal, thought to have developmental origins, and a prevalence rate of 20%. Previous theory and research suggest that trait ASMR may be underlined by atypical multisensory perception from both interoceptive and exteroceptive modalities. In this study, we examined whether ASMR responders differed from nonresponders in interoceptive accuracy and multisensory processing style. Results showed that ASMR responders had lower interoceptive accuracy but a greater tendency towards sensation seeking, especially for tactile, olfactory, and gustatory modalities. Exploratory mediation analyses suggest that sensation-seeking behaviours in trait ASMR could reflect a compensatory mechanism for either deficits in interoceptive accuracy, a tendency to weight exteroceptive signals more strongly, or both. This study provides the foundations for understanding how interoceptive and exteroceptive mechanisms might explain not only the ASMR trait, but also individual differences in the ability to experience complex positive emotions more generally.
9. Building the New Show
Authors: Farmer Paul 
Published: September 2023

Brecht on Theatre becomes a significant influence at this time. In this A39 was moving against the structuralist/poststructuralist/postmodernist flow of academic fashion, but we have no connection with that world and it has no resonance in ours.
Brecht, even more than McGrath, insisted that theatre is a virtuoso art. We identify A39 in Brecht’s description of Epic Theatre, and his description of the ‘V-Effekt’ encourages us to deal differently with the formulation and performance of protagonists. Brecht’s demands for ‘pedagogics’ brings him into conflict with McGrath, but experiences with the aspects of One & All! formally most influenced by McGrath bring us down firmly on Brecht’s side. This informs the conception of an aesthetic within which the new show will operate.
The new play will be about the Industrial Revolution as embodied by the Cornish engineer Richard Trevithick, the inventor of the steam locomotive and many other innovations, and why his life ended in poverty and failure while others made fortunes from his works. We will use Trevithick’s story to demonstrate how capitalism came to be what it is and why its time must end.
A Spatial Analysis of Decisions Made in Response to Simulated Tornado Warnings in the United States
Authors: DeWinter-Maciag Taylor A. , McPherson Renee A. 
Published: September 2023

Abstract
Although decision-making in response to tornado warnings is well researched, most studies do not examine whether individual responses to these warnings vary across different geographical locations and demographic groups. This gap is addressed by using data from a decision experiment that places participants virtually in a simulated tornado warning and asks them to minimize the costs of their decisions. The authors examine the following: 1) what demographic attributes may contribute to choices to minimize costs to protect assets at a specific location in a tornado warning, 2) whether there is a spatial component to how these attributes influence decision-making, and 3) if there are specific U.S. regions where individuals do not make protective decisions that minimize their overall cost. Multilevel regression analysis and poststratification are applied to data from the simulated decision experiment to estimate which demographic attributes and National Weather Service County Warning Areas are most associated with the costliest protective decisions. The results are then analyzed using spatial autocorrelation to identify spatial patterns. Results indicate that sex, race, and ethnicity are important factors that influence protection decisions. Findings also show that people across the southern portions of the United States tend to make more costly protective decisions, as defined in this work.

Significance Statement
Tornadoes, although rare, threaten both life and property. Studies have shown that certain demographic groups are more negatively impacted by disasters than others and are at higher risk of severe weather hazards. We ask if there are demographic characteristics or geographic locations in common among people who are more prone to making protection decisions during tornado warnings to minimize economic costs. Results can help warning providers, such as the National Weather Service, direct resources and education to specific types of decision-makers or locations to improve sheltering decisions.
Excess suicides in Brazil during the first 2 years of the COVID-19 pandemic: Gender, regional and age group inequalities
Authors: Orellana Jesem Douglas Yamall , de Souza Maximiliano Loiola Ponte , Horta Bernardo Lessa 
Published: September 2023

Background: While the COVID-19 pandemic’s total impact on global mortality is uncertain, an estimated 15 million excess deaths occurred during the first two pandemic years, suggesting that a broad impact, since several causes of death showed a substantial rise. Aims: To estimate excess suicides in Brazil and evaluate differences within and between subgroups during the first 2 years of the COVID-19 pandemic. Method: Based on suicide data from the mortality information system of the Brazilian Ministry of Health, the expected number of suicides was estimated by age group, gender, 4-month periods and regions through quasi-Poisson generalized additive models. Analyses were performed in R software and RStudio. Results: Between March 2020 and February 2022, 29,295 suicides were reported in Brazil, close to what would be expected (30,116; 95% Confidence Interval (95% CI): [28,009, 32,224]), albeit in males and females aged 30 to 59 years and 60 years and over, there were excess suicides in at least one of the six 4-month periods evaluated, especially in the second pandemic year. In the Southeast region, a 28% increase was observed in women 60 years and older during the second year. In the North region, suicide increased 23% and 32% among women aged 30 to 59 years during the first and second pandemic years, respectively. The Northeast region had a 16% excess in suicides among men aged 30 to 59 years and 61% among women 60 years old and older during the second pandemic year, reaching 83% in July to October 2021. Conclusions: During the first 2 pandemic years, the pattern of suicides was not homogeneous in Brazil. There were substantial excess suicides in women aged 30 to 59 years from the North and Northeast, while among the elderly and men there was a consistent pattern in several four-month periods throughout Brazil.