bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of heart failure phenotypes and current use of therapies in primary care: results from a nationwide study
Authors: Jensen Jesper , Poulsen Mikael Kjær , Petersen Per Warrer , Gerdes Bo , Rossing Kasper , Schou Morten 
Published: February 2023

AbstractAimsHeart failure (HF) is an increasing concern worldwide. A rising HF burden is expected due to the prospected future demographic changes with aging populations. Consequently, the long‐term follow‐up and treatment will be performed increasingly by primary care physicians in the future. Contemporary data on HF patients in primary care are needed to plan and ensure an effective and safe follow‐up of future patients.Methods and resultsThe electronic patient journals of 148 primary care clinics in Denmark were searched in a standardized manner to identify patients with HF [code K77 of the International Classification of Primary Care, Second Edition]. Prespecified variables including demographic information, clinical variables, co‐morbidities, prescribed medications, and setting of follow‐up were recorded. In total, 1111 patients were included in the study. The mean timepoint for the HF diagnosis was August 2018. In 95% of cases, the diagnosis of HF was made in a specialized setting. The echocardiogram data used for phenotyping were available in 1042 (94%) of the 1111 patients. HF with reduced ejection fraction (HFrEF) was present in 43%, recovered HFrEF in 31%, and HF with mildly reduced (HFmrEF) or preserved ejection fraction (HFpEF) in 26%. In patients with HFrEF or recovered HFrEF, fundamental treatments were prescribed in 86% for angiotensin converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB), or angiotensin receptor neprilysin inhibitor (ARNI), in 82% for beta‐blocker, in 38% for mineralocorticoid receptor antagonist (MRA), and in 12% for sodium‐glucose co‐transporter‐2 inhibitor (SGLT2i). Older patients were treated to a significantly lesser extent than young patients for all drug classes [odds ratio (OR) point estimates 0.50 to 0.69, all P‐values < 0.05]. In patients with HFmrEF or HFpEF, an ACEI, ARB, or ARNI was prescribed in 67%, beta‐blocker in 67%, MRA in 22%, and SGLT2i in 7.4% with significantly lower probability of treatment compared to patients with HFrEF or recovered HFrEF [OR point estimates 0.33 to 0.57, all P‐values < 0.05]. The setting of follow‐up was available in 96% of patients. Irrespective of HF phenotype, follow‐up was performed solely in primary care in 64%. These patients were generally treated to a lesser extent with HF therapies compared with patients where follow‐up included specialized care, yet differences were generally small.ConclusionsHFrEF is the most common phenotype of HF in primary care followed by recovered HFrEF and fundamental therapies are markedly underutilized. Initiatives to increase the use of recommended therapies are needed to improve the future care of patients with HF.
New Synthetic Route for Reaching Higher Phase Stabilization in LAMOX‐Based Electrolyte for Solid Oxide Fuel Cells
Authors: Hchicha Khouloud , Mhadhbi Noureddine , Guesmi Ahlem , Soltani Taoufik , Hamadi Naoufel Ben , Naïli Houcine 
Published: February 2023

AbstractS‐substituted La2Mo2O9 were synthesized by a solid‐state procedure employing ammonium sulfate (NH4)2SO4 as a sulfur source. The synthesized powders were examined using X‐ray diffraction (XRD), thermogravimetric analysis (TGA), infrared, and Raman spectroscopies. The results divulged that the stabilization of the β‐La2Mo2O9 polymorph occurred in the interval of sulfur composition 0.1≤y≤0.6. This substitution generates a linear dwindling of the unit cell volume. The decomposition of all substituted samples started above 900 °C with a total weight loss linearly dependent on the sulfur content. Electrical studies confirmed that substituting S6+ for Mo6+ suppresses the phase transition of La2Mo2O9 and stabilizes the cubic polymorph down to ambient temperature. It was also remarkable that this substitution caused a decrease in the conductivity, and unfortunately, none of the tested compositions allowed exceeding the conductivity of La2Mo2O9. Infrared and Raman spectra confirmed the presence of the characteristic peaks of sulfates and molybdates groups.
Chemically modified pencil electrodes for application in reagentless chronopotentiometric antioxidant activity measurement
Authors: Muthuri Lawrence K. , Nagy Livia , Nagy Géza 
Published: February 2023

AbstractRecently a novel chronopotentiometric method has been introduced that was found useful for assessing antioxidant activity. In our experiments, the performance of chemically modified working electrodes made of different pencil materials were tested in the novel method. Redox mediator film of Meldola Blue was formed on electrode surfaces. The stability of the film, the number of molecules structuring it has been studied. In antioxidant measurements, controlled potential oxidation of the mediator was made followed by recording the open cell potential in time. The initial slope of this was used as analytical signal. Results proved applicability of the pencil probes.
A smart mechanical‐energy harvesting and self‐heating textile device for photo‐thermal energy utilization
Authors: Wang Hui , Yu Yunfei , Yang Xiaoyu , Wang Shuo , Ge Jing , Yang Qingbin , Zhou Xinlei , Zheng Guoqiang , Dai Kun , Dai Xingyi , Feng Yiyu , Huang Long‐Biao , Feng Wei 
Published: February 2023

AbstractA smart textile that could harvest mechanical‐energy for photo‐thermal energy utilization facilitates the development of a flexible self‐heating wearable device. This study presents novel triboelectric materials with a dynamic‐bond‐cross‐linking azobenzene‐based polymer (PAzo‐M) with diverse metal ions. The flexible nylon fabric coated with PAzo‐M (NF@PAzo‐M) serves as a friction layer of the photothermal triboelectric nanogenerator (PT‐TENG) to harvest human mechanical energy. The prepared PT‐TENG could exhibit a maximum open‐circuit voltage of up to 188.8 V with excellent electron loss capability because of its minimum vertical electron affinity of internal ion. And it can harvest mechanical energy from human motion (0.5–1 Hz) to drive the self‐powering irradiation of ultraviolet light or visible light, leading to the reversible isomerization of NF@PAzo‐M. The NF@PAzo‐M textile cyclically utilizes photo‐thermal energy for self‐heating. These results suggest new opportunities to harvest human mechanical energy for self‐powering multifunctional wearable devices for functions.image
Klimabezogene Optimierung von Baugrundverbesserungen – Multidisziplinärer Ansatz zur Verknüpfung von Ökobilanz und technischen Aspekten
Authors: Knabe Birthe , Tinat Christopher , Rosenberg Matthias 
Published: February 2023

AbstractDie Bewertung von Bauprozessen hinsichtlich umweltrelevanter Aspekte nimmt an Bedeutung zu und ist für die Baupraxis von besonderem Interesse. Es wird eine Bewertungsmethode für die Rüttelstopfverdichtung (RSV) und die dynamische Intensivverdichtung (DYNIV) mit Einschlagen von sog. DYNIV‐Säulen vorgestellt, welche sowohl technische als auch umweltrelevante Kriterien einbezieht. Zur Bewertung der umweltrelevanten Aspekte wird die Ökobilanzierung angewendet. Aufgrund der durch die Klimakrise zunehmenden Bedeutung des globalen Erwärmungspotenzials (GWP) wird dieses als maßgeblicher Indikator für die Beurteilung der Umweltrelevanz festgelegt.Mit den beiden hier betrachteten Verfahren zur Baugrundverbesserung werden granulare Säulen hergestellt, wobei die DYNIV in verdichtbaren Böden zusätzlich eine signifikante Verbesserung der Bodeneigenschaften unterhalb des Säulenfußes erzeugt. An einem konkreten Projektbeispiel eines Logistikzentrums zeigen die Analyseergebnisse daher Vorteile der DYNIV hinsichtlich der Umweltwirkungen. Bei dem im Rahmen dieser Untersuchung definierten Setzungskriterium können die DYNIV‐Säulen im Vergleich zu der RSV bis zu 60 % des GWP einsparen. Lässt man größere Setzungen zu, könnten die Umweltwirkungen beider Verfahren weiter reduziert werden. Diese Entscheidung wird künftig durch die Bauherren zu treffen sein. Am vorliegenden Beispiel wird die multidisziplinäre Optimierung mit den beiden Kriterien Minimierung der Setzung sowie Minimierung des GWP durchgeführt.
Boots on the ground: Foreign direct investment by born digital firms
Authors: Stallkamp Maximilian , Chen Liang , Li Sali 
Published: February 2023

AbstractResearch SummaryRecent global strategy research on born digital firms (i.e., firms with digital products distributed through digital channels) has paid only limited attention to the role of foreign direct investment (FDI) in the internationalization of such firms. We argue that exploiting digital technologies requires a range of complementary, non‐digital resources. Born digitals typically deploy FDI when large cultural and geographic distances limit the fungibility and scalability of such complementary resources, leading to a positive relationship between distance (cultural and geographic) and FDI. The positive distance effect is moderated by business model type. Using a sample of US‐based born digital firms with over 800 FDIs, we find support for our hypotheses and contribute an important empirical baseline to recent discussions of digitalization in global strategy.Managerial SummaryCompanies selling digital products (e.g., software, cloud‐based services) are theoretically able to offer their products in foreign markets through internet‐based channels, without ever setting foot in a foreign country. And yet, many “born digital” firms establish a physical presence in foreign markets by undertaking foreign direct investment (FDI). This phenomenon remains insufficiently explained. We argue that FDI can supply important complementary resources that help exploit and monetize digital assets in foreign markets. Using data from over 800 FDI projects, we show that FDI is more likely to occur if the foreign market is far away or culturally very different from the company's home country, and that the strength of this relationship differs among B2C and B2B business models.
Diagnostic value of peripheral blood miR‐296 combined with vascular endothelial growth factor B on the degree of coronary artery stenosis in patients with coronary heart disease
Authors: Xu Lei , Fu Ting , Wang Yu , Ji Ningning 
Published: February 2023

AbstractObjectiveCoronary heart disease (CHD) is a disorder resulting from organic and functional coronary artery stenosis (CAS), thus causing reduced oxygenated blood in the heart. miRNAs are useful biomarkers in the diagnosis of atherosclerosis, CHD, and acute coronary syndrome. Vascular endothelial growth factor (VEGF) is closely related to CHD. This study explored the correlation of miR‐296 and VEGF‐B expression levels in peripheral blood with CAS degree in CHD patients.MethodsTotally 220 CHD patients were enrolled and classified into mild‐(71 cases)/moderate‐(81 cases)/severe‐CAS (68 cases) groups, with another 80 healthy cases as controls. The serum miR‐296 and VEGF‐B expression levels were detected using reverse transcription quantitative polymerase chain reaction. The correlation between miR‐296 and CAS‐related indexes was assessed via Pearson analysis. The binding relationship of miR‐296 and VEGF‐B was first predicted and their correlation was further analyzed via the Pearson method. The clinical diagnostic efficacy of miR‐296 or VEGF‐B on CAS degree was evaluated by the receiver operating characteristic curve.ResultsSerum miR‐296 was downregulated in CHD patients and was the lowest in patients with severe‐CAS. miR‐296 was negatively‐correlated with high‐sensitivity C‐reactive protein, brain natriuretic peptide, and cardiac troponin I. miR‐296 targeted VEGF‐B. VEGF‐B was upregulated in CHD patients and inversely‐related to miR‐296. Low expression of miR‐296 and high expression of VEGF‐B both had high clinical diagnostic values on CAS degree in CHD patients. miR‐296 combined with VEGF‐B increased the diagnostic value on CAS.ConclusionLow expression of miR‐296 combined with high expression of its target VEGF‐B predicts CAS degree in CHD patients.
Prevalence and whole‐genome sequencing characterization of Salmonella in urban karst groundwater and predominantly groundwater‐fed surface waters for serotypes and antimicrobial resistance
Authors: Agga Getahun E. , Kaiser Rachel , Polk Jason , Allard Marc 
Published: February 2023

AbstractKarst aquifers provide a significant source of drinking water around the world; however, they are prone to bacterial contamination. We investigated the prevalence, serotypes, and antimicrobial resistance genes (ARGs) of Salmonella in urban karst groundwater and groundwater‐fed surface waters. Weekly water samples (n = 443) were collected from nine groundwater sites and the Barren River in Bowling Green, KY. Additionally, cross‐sectional samples were collected from 45 sites, including groundwaters and two rivers, in Tampa, FL. Salmonella was detected in 14.5% of Bowling Green samples resulting in 176 isolates representing 18 serotypes. Two (4.4%) of the Tampa samples were positive yielding eight isolates representing two serotypes. In Bowling Green, Salmonella prevalence varied by sampling site, week, month, and season, with the highest prevalence in surface water in the month of November and during summer. Salmonella Newport was the most common serotype detected. Nine of the serotypes detected in the study were among the top 20 serotypes commonly associated with human infections in the United States. Isolates were clustered with human clinical isolates, or isolates obtained from food animals, suggesting the importance of humans and agricultural practices as a source of water contamination. ARGs were detected in 12.5% (n = 176) of the Bowling Green isolates; overall, 81.8% (n = 22) of these were multidrug‐resistant (resistance to ≥3 antimicrobial classes). Notably, the four Salmonella Agona isolates were resistant to four antimicrobial classes, mercury, and quaternary ammonium compounds. Seasonality and the widespread occurrence of Salmonella both in the groundwater and groundwater‐fed surface waters is a potential risk to public health.
Sex effects on gingival transcriptomic patterns during initiation, progression, and resolution of periodontitis
Authors: Ebersole Jeffrey L. , Kirakodu Sreenatha S. , Nguyen Linh M. , Gonzalez Octavio A. 
Published: February 2023

AbstractBackgroundThe prevalence and severity of periodontitis demonstrates altered population distribution with age, sex, and race and ethnicity. While males exhibit greater frequency of disease, particularly with aging, the underlying basis for this observation remains obscure.ObjectiveThis study used a nonhuman primate (Macaca mulatta) model of experimental ligature‐induced periodontitis in adult animals to evaluate gingival transcriptomic differences stratified based upon sex of the animal.MethodsThe 18 animals represented humans ages 40–80 years, with gingival tissue samples obtained at baseline, 0.5 months (initiation), 1 and 3 months (progression), and at 5 months that were 60 days after ligature removal for clinical disease resolution. Microarray analysis was used to quantify gene expression profiles in the gingival tissues.ResultsThe results demonstrated clear gene expression differences in healthy (baseline) tissues between the sexes, with elevations in females associated with immune responses and elevation in males related to tissue structural genes. With disease initiation, fewer genes differed between the sexes, while these differences were significantly increased in progressing disease and resolution, particularly in male animals. Overexpressed biological processes showed tissue structural/functional genes at initiation, with host response pathways altered during disease progression. Resolution samples generally demonstrated biological processes of cellular metabolism that differed from baseline healthy samples.ConclusionThe transcriptomic findings support sex as a biological variable in periodontitis using a nonhuman primate model of experimental periodontitis.
Preparation of degradable amphoteric surfactant and property evaluation of clean fracturing fluid
Authors: Chen Mengjin , Pi Jinyu , Shi Yali , Chen Tianqi , Fu Chaoyang 
Published: February 2023

AbstractThe main agent of clean fracturing fluid, cationic quaternary ammonium salt surfactant, is difficult to degrade in natural conditions because of its long alkyl chain. In this study, a biodegradable amphoteric surfactant, stearate sulfobetaine (SESB), was synthesized by esterification of long‐chain stearic acid and N,N‐dimethyl ethanolamine followed by quaternization to serve as the main agent of clean fracturing fluid. The structure of the synthetic degradable surfactant was verified by infrared and 1H‐nuclear magnetic resonance spectroscopies. In addition, a series of indoor performance evaluations were carried out, including shear resistance, viscoelasticity, sand carrying capacity, and gel‐breaking performance. A series of experimental evaluations showed that the clean fracturing fluid prepared with 2% SESB and 0.4% EDTA‐4Na had an excellent comprehensive performance. The apparent viscosity was higher than 50 mPa s at 80°C for a shear rate of 170 s−1. It has good heat and shear resistance performance. In addition, the system processed high shear stability and recovery at room temperature. According to the viscoelastic test, the system mainly relies on elasticity to carry sand. The static settling velocity of sand was 0.042 mm/s under high‐temperature conditions of 95°C.
Fine structural features and antioxidant capacity of ferulated arabinoxylans extracted from nixtamalized maize bran
Authors: Marquez‐Escalante Jorge A , Carvajal‐Millan Elizabeth , Martínez‐López Ana L , Martínez‐Robinson Karla G , Campa‐Mada Alma C , Rascon‐Chu Agustín 
Published: February 2023

AbstractBACKGROUNDThe nixtamalization process improves the nutritional and technological properties of maize. This process generates nixtamalized maize bran as a by‐product, which is a source of arabinoxylans (AX). AX are polysaccharides constituted of a xylose backbone with mono‐ or di‐arabinose substitutions, which can be ester‐linked to ferulic acid (FA). The present study investigated the fine structural features and antioxidant capacity (AC) of nixtamalized maize bran arabinoxylans (MBAX) to comprehend the structure–radical scavenging capacity relationship in this polysaccharide deeply.RESULTSMBAX presented a molecular weight, intrinsic viscosity, and hydrodynamic radius of 674 kDa, 1.8 dL g−1, and 24.6 nm, respectively. The arabinose‐to‐xylose ratio (A/X) and FA content were 0.74 and 0.25 g kg−1 polysaccharide, respectively. MBAX contained dimers (di‐FA) and trimer (tri‐FA) of FA (0.14 and 0.07 g kg−1 polysaccharide, respectively). The main di‐FA isomer was the 8–5′ structure (80%). Fourier transform infrared spectroscopy confirmed MBAX molecular identity, and the second derivate of the spectral data revealed a band at 958 cm−1 related to the presence of arabinose disubstitution. 1H‐Nuclear magnetic resonance spectroscopy showed mono‐ and di‐arabinose substitution in the xylan backbone with more monosubstituted residues. MBAX registered an AC of 25 and 20 μmol Trolox equivalents g−1 polysaccharide despite a low FA content, using ABTS (2,2′‐azino‐bis‐3‐ethylbenzthiazoline‐6‐sulfonic acid) and DPPH (1,1‐diphenyl‐2‐picrylhydrazyl) methods, respectively.CONCLUSIONAC in MBAX could be related to the high A/X ratio (mainly monosubstitution) and the high 8–5′ di‐FA proportion in this polysaccharide. © 2023 Society of Chemical Industry.
Improvement of shelf‐life of cherry (Prunus avium L.) by combined application of modified‐atmosphere packaging and antagonistic yeast for long‐distance export
Authors: Cabañas Catalina M. , Hernández Alejandro , Serradilla Manuel J. , Moraga Carlos , Martín Alberto , Córdoba María de Guía , Ruiz‐Moyano Santiago 
Published: February 2023

AbstractBACKGROUNDThe last decade has seen a growing interest in reducing the use of chemical fungicides for postharvest decay control. In the research for new, safe alternatives, the combined application of biocontrol agents and passive modified‐atmosphere packaging (MAP) has been shown to be a promising strategy to extend fruit quality. Therefore, the aim of this work was to evaluate the effect of the combined application of MAP and two antagonistic yeasts, Metschnikowia pulcherrima L672 and Pichia kudriavzevii PK18, on sweet cherry shelf life.RESULTSMicrobiological, physico‐chemical, and quality fruit analysis from batches treated with antagonistic yeast were compared with a control batch without yeast application and a batch to which fludioxonil (Scholar®) was applied. The composition of the atmosphere and physico‐chemical traits showed similar values among the different batches during cold storage. However, interestingly, the combination of MAP with the antagonistic yeasts M. pulcherrima L672 and P. kudriavzevii PK18 increases the control of microbiological spoilage with results comparable to the application of fludioxonil. In addition, these batches experienced a slight decrease in volatile compounds associated with fresh fruit aroma, whereas in the control batch an increase of altered fruit aromas was observed. The same effect of control of spoilage was observed during the shelf life period.CONCLUSIONThese results showed the positive effect of the combination of antagonistic yeasts and MAP, obtaining similar results in terms of control of microbiological spoilage and physico‐chemical quality compared with the application of fludioxonil. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Use of metagenomics and metabolomics to quantify changes in rhizosphere soil microbial function in response to mulching regimes
Authors: Tian Lixin , Zhang Feifei , Zhang Lei , Gao Xiaoli , Feng Baili 
Published: February 2023

AbstractThe effects of distinct mulching regimes on the microbial functional properties and metabolic profiles of rhizosphere soil remain largely unknown. Here, we conducted metagenomic and metabolomic analyses to explore the microbial functional specificity and metabolic pathways under three mulching regimes, namely, traditional flat planting with non‐mulch (TP), ridge‐furrow plastic film mulching (RF), and plastic film mulching (PFM). Compared to TP treatment, RF and PFM treatments significantly improved the soil temperature and moisture content, stimulated the increase of five extracellular enzyme activities, thereby reducing soil nutrient content (soil pH, total N, soil organic carbon, NH4+‐N, and NO3−‐N) to meet crop demand for nutrients. In addition, RF treatment significantly decreased the relative abundance of nxrA, while increasing the relative abundance of nasA, thereby further decreasing NO3−‐N content. However, RF and PFM treatments had no significant effect on the relative abundance of nirB, nirD, nrfA, and nrfH. Meanwhile, PFM and RF treatment stimulated the increase of extracellular enzyme activities accelerated microbial metabolism, thereby promoting the synthesis of metabolites involved in carbohydrate metabolism, lipid metabolism, nucleotide metabolism, and amino acid metabolism. Metabolomics and network analyses revealed that RF and PFM treatments not only enriched organoheterocyclic compounds, organic acids and derivatives, lipids and lipid‐like molecules, and organic oxygen compounds but also increased their relative abundance in the major modules. Overall, this study provides deep insights into how mulching regimes alter soil microbial functional potential and metabolic profiles, which may have predictable impacts on the rhizosphere soil nutrient cycling of agroecosystems under mulching systems in semiarid regions.