bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proposing new early detection indicators for pancreatic cancer: Combining machine learning and neural networks for serum miRNA-based diagnostic model
Authors: Chi Hao , Chen Haiqing , Wang Rui , Zhang Jieying , Jiang Lai , Zhang Shengke , Jiang Chenglu , Huang Jinbang , Quan Xiaomin , Liu Yunfei , Zhang Qinhong , Yang Guanhu 
Published: August 2023

BackgroundPancreatic cancer (PC) is a lethal malignancy that ranks seventh in terms of global cancer-related mortality. Despite advancements in treatment, the five-year survival rate remains low, emphasizing the urgent need for reliable early detection methods. MicroRNAs (miRNAs), a group of non-coding RNAs involved in critical gene regulatory mechanisms, have garnered significant attention as potential diagnostic and prognostic biomarkers for pancreatic cancer (PC). Their suitability stems from their accessibility and stability in blood, making them particularly appealing for clinical applications.MethodsIn this study, we analyzed serum miRNA expression profiles from three independent PC datasets obtained from the Gene Expression Omnibus (GEO) database. To identify serum miRNAs associated with PC incidence, we employed three machine learning algorithms: Support Vector Machine-Recursive Feature Elimination (SVM-RFE), Least Absolute Shrinkage and Selection Operator (LASSO), and Random Forest. We developed an artificial neural network model to assess the accuracy of the identified PC-related serum miRNAs (PCRSMs) and create a nomogram. These findings were further validated through qPCR experiments. Additionally, patient samples with PC were classified using the consensus clustering method.ResultsOur analysis revealed three PCRSMs, namely hsa-miR-4648, hsa-miR-125b-1-3p, and hsa-miR-3201, using the three machine learning algorithms. The artificial neural network model demonstrated high accuracy in distinguishing between normal and pancreatic cancer samples, with verification and training groups exhibiting AUC values of 0.935 and 0.926, respectively. We also utilized the consensus clustering method to classify PC samples into two optimal subtypes. Furthermore, our investigation into the expression of PCRSMs unveiled a significant negative correlation between the expression of hsa-miR-125b-1-3p and age.ConclusionOur study introduces a novel artificial neural network model for early diagnosis of pancreatic cancer, carrying significant clinical implications. Furthermore, our findings provide valuable insights into the pathogenesis of pancreatic cancer and offer potential avenues for drug screening, personalized treatment, and immunotherapy against this lethal disease.
Distribution of transpulmonary pressure during one-lung ventilation in pigs at different body positions
Authors: Wittenstein Jakob , Scharffenberg Martin , Yang Xiuli , Bluth Thomas , Kiss Thomas , Schultz Marcus J. , Rocco Patricia R. M. , Pelosi Paolo , Gama de Abreu Marcelo , Huhle Robert 
Published: August 2023

Background. Global and regional transpulmonary pressure (PL) during one-lung ventilation (OLV) is poorly characterized. We hypothesized that global and regional PL and driving PL (ΔPL) increase during protective low tidal volume OLV compared to two-lung ventilation (TLV), and vary with body position.Methods. In sixteen anesthetized juvenile pigs, intra-pleural pressure sensors were placed in ventral, dorsal, and caudal zones of the left hemithorax by video-assisted thoracoscopy. A right thoracotomy was performed and lipopolysaccharide administered intravenously to mimic the inflammatory response due to thoracic surgery. Animals were ventilated in a volume-controlled mode with a tidal volume (VT) of 6 mL kg−1 during TLV and of 5 mL kg−1 during OLV and a positive end-expiratory pressure (PEEP) of 5 cmH2O. Global and local transpulmonary pressures were calculated. Lung instability was defined as end-expiratory PL&lt;2.9 cmH2O according to previous investigations. Variables were acquired during TLV (TLVsupine), left lung ventilation in supine (OLVsupine), semilateral (OLVsemilateral), lateral (OLVlateral) and prone (OLVprone) positions randomized according to Latin-square sequence. Effects of position were tested using repeated measures ANOVA.Results. End-expiratory PL and ΔPL were higher during OLVsupine than TLVsupine. During OLV, regional end-inspiratory PL and ΔPL did not differ significantly among body positions. Yet, end-expiratory PL was lower in semilateral (ventral: 4.8 ± 2.9 cmH2O; caudal: 3.1 ± 2.6 cmH2O) and lateral (ventral: 1.9 ± 3.3 cmH2O; caudal: 2.7 ± 1.7 cmH2O) compared to supine (ventral: 4.8 ± 2.9 cmH2O; caudal: 3.1 ± 2.6 cmH2O) and prone position (ventral: 1.7 ± 2.5 cmH2O; caudal: 3.3 ± 1.6 cmH2O), mainly in ventral (p ≤ 0.001) and caudal (p = 0.007) regions. Lung instability was detected more often in semilateral (26 out of 48 measurements; p = 0.012) and lateral (29 out of 48 measurements, p &lt; 0.001) as compared to supine position (15 out of 48 measurements), and more often in lateral as compared to prone position (19 out of 48 measurements, p = 0.027).Conclusion. Compared to TLV, OLV increased lung stress. Body position did not affect stress of the ventilated lung during OLV, but lung stability was lowest in semilateral and lateral decubitus position.
Impaired decision-making in borderline personality disorder
Authors: Bajzát Bettina , Soltész Péter , Soltész-Várhelyi Klára , Lévay Evelyn Erika , Unoka Zsolt Szabolcs 
Published: August 2023

IntroductionBorderline personality disorder (BPD) is a complex mental disorder with core symptoms like interpersonal instability, emotion dysregulation, self-harm, and impulsive decision-making. Previous neuropsychological studies have found impairment in the decision-making of patients with BPD related to impulsivity. In our study, we focus on a better, more nuanced understanding of impulsive decision-making in BPD with the help of Rogers’ decision-making test that simulates a gambling situation.MethodsA novelty of our study is that we excluded from further analysis non-compliant participants based on their performance. Outlier participants on the measures proportion of good choices and average of wager choice number were filtered out to represent the population that understood the basic premise of the task and showed minimal motivation to gain rewards. Thus participants often choosing the less likely color or frequently choosing the first bet amount available (to probably speed up the test) were omitted from further analysis. Another novelty is that we assessed and reported six variables that examine Deliberation Time, Quality of Decision, Risk-taking, Overall proportion bet, Delay aversion, and Risk adjustment. Forty-three women with BPD participated in the study, and 16 non-compliant were excluded. As for the healthy control group, 42 women participated in the study, and four non-compliant were excluded. Thus, we compared the data of 27 patients with BPD with 38 healthy controls.ResultsOur results show that there are significant differences amongst the groups regarding the Quality of Decision Making (F (1,63) = 5.801, p = 0.019) and Risk Adjustment (F (1,63) = 6.522, p = 0.013). We also found significant interactions between group and winning probability regarding Risk Taking (F (4,252) = 4.765 p = 0.001) and Overall proportion of bets, i.e., the average proportion of bets relative to the total score of the subject (F (4,252) = 4.505, p = 0.002).DiscussionOur results show that the two groups use different decision-making strategies that can have various associations with everyday life situations.
Public’s preferences for health science popularization short videos in China: a discrete choice experiment
Authors: Xiao Li , Min Hewei , Wu Yibo , Zhang Jieyu , Ning Yan , Long Long , Jia Kaixiang , Jing Weilong , Sun Xinying 
Published: August 2023

BackgroundHealth science popularization short video disseminates health information to the public in an understandable way about health information.ObjectiveTo investigate the preferences of Chinese residents for health science popularization short videos and provide suggestions for optimizing the production of short videos.MethodsAn online survey of Chinese people was conducted using a self-administered questionnaire, and a discrete choice experiment (DCE) was used to explore the public’s preferences for health science popularization short videos.ResultsA total of 618 respondents were included, of which 306 (45.51%) were male and 312 (50.49%) were female, 271 (43.85%) were aged 18–25, 239 (38.67%) were aged 26–60, and 108 (17.48%) were aged 60 and above. Whether the video is charged or not (46.891%) and the account subject (28.806%) were both considered important. The results of the DCE revealed that the participants considered video free of charge as the most significant attribute of health science popularization short videos (OR 3.433, 95% CI 3.243–3.633). Overall, participants preferred and were more willing to pay for health science popularization short videos with a hospital account subject (OR 1.192, 95% CI 1.116–1.274), with the form of graphic narration (OR 1.062, 95% CI 1.003–1.126), free of charge (OR 3.433, 95% CI 3.243–3.633), with the content that satisfies their needs (very much needed: OR 1.253, 95% CI 95% CI 1.197–1.311; generally needed: OR 1.078, 95% CI 1.029–1.129), with platform certification (OR 1.041, 95% CI 1.011–1.073), without commercial advertisements (OR 1.048, 95% CI 1.018–1.080), with simple-to-understand content (OR 1.071, 95% CI 1.040–1.104), and with video content that evokes fear or dread of illness in the viewer (OR 1.046, 95% CI 1.015–1.078).ConclusionParticipants favor free health popularization short videos, which are hospital accounts, with content that is illustrated, understandable, meets their needs, and can serve as a warning. In the future, the production of health popularization short videos should focus on improving the diversity and relevance of video content, making it as easy to understand to achieve good science popularization effects.
Depression and academic engagement among college students: the role of sense of security and psychological impact of COVID-19
Authors: Tang Yuxi , He Weiguang 
Published: August 2023

BackgroundThe negative consequences of depression in college students have garnered global attention, especially in relation to academic achievement during the COVID-19 pandemic, which need critical assessment.AimThis study investigated whether a sense of security mediated the relationship between depression and academic engagement among college students during the pandemic and whether the moderating psychological impact of COVID-19 has a moderating effect on this relationship.MethodsIn this cross-sectional study, we recruited 466 college students from 30 provincial-level administrative regions in China via the Internet and used established scales to measure depression, academic engagement, a sense of security, and the psychological impact of COVID-19. The mediating and moderating effects were tested using the bootstrap method.ResultsDepression was found to negatively influence academic engagement, with a sense of security partially mediating this relationship. Moreover, the psychological impact of COVID-19 was shown to have a moderating effect on this mediating process.ConclusionThis study could aid in crafting pertinent strategies to mitigate the adverse effects of depression on learning amid unexpected public health crises and foster better mental health among college students.
Pengembangan Buku Ajar Tema Peduli Lingkungan untuk Meningkatkan Keterampilan Berpikir Kreatif Anak Usia 5-6 Tahun
Authors: Lailatun nazar  , Mallevi Agustin Ningrum  , Kartika Rinakit Adhe  , Melia Dwi Widayanti  
Published: August 2023

This study aims to determine the feasibility, practicality, and effectiveness of textbooks on the theme of caring for the environment to improve the creative thinking skills of children aged 5-6 years. This study uses the Research and Development model with the ADDIE model. The subjects that were the focus of this study were ten students from group B who attended TK DWP Karangankidul. The results of this study, it was found that textbooks on the theme of caring for the environment were deemed appropriate based on validation by material experts and textbook design experts, the average percentage of validation obtained was 95.34%, which means textbooks on the theme of caring for the environment are very suitable for use by teachers group B. The practicality of textbooks on the theme of caring for the environment obtained an average percentage of 9 Kindergarten teachers in group B of 91.66%, which means that textbooks are very practical to use. The effectiveness of textbooks on the theme of caring for the environment was analyzed using the Wilcoxon test calculations through SPSS 22. The results of the analysis showed that the Asymp. sing. (2-tailed) of 0.005. So that the p-value <0.05 or 0.005 <0.05, then H0 is rejected and H1 is accepted. It can be concluded that the use of environmental care theme textbooks is effective in improving the creative thinking skills of children aged 5-6 years.
ABSTRAK
Penelitian ini dilakukan dengan tujuan untuk mengetahui kelayakan, kepraktisan, dan keefektifan buku ajar tema peduli lingkungan untuk meningkatkan keterampilan berpikir kreatif anak berusia 5-6 tahun. Penelitian ini menerapkan pendekatan pengembangan penelitian (Research and Development) dengan menggunakan model ADDIE. Subjek yang menjadi fokus dalam penelitian ini adalah sebanyak 10 anak didik dari kelompok B yang bersekolah di TK DWP Karangankidul. Hasil penelitian ini, ditemukan bahwa buku ajar tema peduli lingkungan telah dianggap layak berdasarkan validasi oleh ahli materi dan ahli desain buku ajar, rata-rata persentase validasi yang diperoleh adalah sebesar 95,34% yang berarti buku ajar tema peduli lingkungan sangat layak untuk digunakan guru kelompok B. Kepraktisan buku ajar tema peduli lingkungan memperoleh rata-rata persentase dari 9 guru Taman Kanak-kanak kelompok B sejumlah 91,66% yang berarti buku ajar sangat praktis digunakan. Keefektifan buku ajar tema peduli lingkungan dianalisis dengan menggunakan perhitungan uji Wilcoxon melalui SPSS 22. Hasil analisis menunjukkan bahwa nilai Asymp. Sing. (2-tailed) sebesar 0,005. Hal ini menunjukkan bahwa nilai p < 0,05 atau 0,005 < 0,05, oleh karena itu H0 ditolak dan H1 diterima. Dengan demikian, dapat disimpulkan bahwa penggunaan buku ajar tema peduli lingkungan efektif dalam meningkatkan keterampilan berpikir kreatif anak usia 5-6 tahun.
Pengaruh Bermain Wire Maze Terhadap Kontak Mata Anak Autis Spectrum Disorder di KB/TK Inklusi Srawung Bocah Yogyakarta
Authors: Dwike Amalia  , Dwi Putri Fatmawati  
Published: August 2023

The effect of playing wire maze on the eye contact of children with autism spectrum disorder in KB/TK Srawung Bocah Inklusi, reports on children's learning outcomes and observations of class teachers concluded that there were student problems in the form of a lack of ability to make eye contact in children so that it affected children's communication activities in learning activities. The aim of the study was to determine the effect of playing wire maze on eye contact in children with autism spectrum disorder. The research was conducted by calculating the frequency of eye contact in ASD children. In this study the researcher used observation and documentation as data collecting technique, with a quantitative approach and the type of experimental research with the Single Subject Research (SSR) design. The results of data analysis found that there were differences in the results in each research phase, it was in the baseline phase which increased in the intervention phase. Based on these results it can be concluded that there is an effect from playing wire maze on the eye contact of ASD children

ABSTRAK
Pengaruh bermain wire maze terhadap kontak mata anak autism spectrum disorder di KB/TK Inklusi Srawung Bocah, laporan hasil belajar anak dan pengamatan guru kelas menyatakan adanya permasalahan siswa berupa kurangnya kemampuan kontak mata anak sehingga mempengaruhi kegiatan anak berkomunikasi dalam kegiatan pembelajaran. Penelitian bertujuan untuk mengetahui pengaruh bermain wire maze terhadap kontak mata anak autism spectrum disorder, penelitian dilakukan dengan menghitung frekuensi munculnya kontak mata pada anak ASD. Pengumpulan data dalam penelitian ini yaitu observasi dan dokumentasi, dengan pendekatan kuantitatif dan jenis penelitian eksperimen dengan desain Single Subject Research (SSR). Hasil Analisis data didapatkan bahwa adanya perbedaan hasil dalam setiap fase penelitian, yaitu pada fase baseline yang meningkat di fase intervensi. Berdasarkan hasil tersebut dapat disimpulkan bahwa terdapat pengaruh bermain wire maze terhadap kontak mata anak ASD.
Pengaruh Pembelajaran Proyek Terhadap Konsentrasi Anak Attention Deficit Hyperactivity Disorder (ADHD)
Authors: Raudatul Jannah  , Dwi Putri Fatmawati  
Published: August 2023

The effect of project learning on the concentration of children with Attention Deficit Hyperactivity Disorder (ADHD). Based on the results of observations, there were children with characteristics of difficulty focusing, excess energy, unable to stay still, and from the results of assessments by the child psychologist, there were indications of ADHD in the KB/TK Inclusive Srawung Bocah. Research conducted aim for influence from projects learning carried to concentration ADHD child . Study with measure duration concentration ADHD child using a stopwatch. Collection of research data used is observation and documentation. This study use approach quantitative, type research used experiment with Single Subject Research (SSR) design . The results of the analysis data obtained that the average duration baseline phase 5.273 minutes and intervention phase 6.3375 minutes . Based on results data analysis can concluded that learning project influential to concentration ADHD child.
ABSTRAK
Pengaruh pembelajaran proyek terhadap konsentrasi anak Attention Deficit Hyperactivity Disorder (ADHD). Berdasarkan hasil oberservasi yang dilakukan sebelum penelitian terdapat anak dengan karakteristik susah fokus, energi berlebih, tidak bisa diam, dan dari hasil asesmen oleh psikolog anak tersebut terindikasi ADHD di KB/TK Inklusi Srawung Bocah. Penelitian bertujuan untuk mengetahui pengaruh dari pembelajaran proyek yang dilakukan terhadap konsentrasi anak ADHD. Pengumpulan data penelitian yang digunakan yaitu observasi dan dokumentasi. Penelitian ini menggunakan pendekatan kuantitatif, jenis penelitian yang digunakan yaitu eksperimen dengan desain Single Subject Research (SSR). Hasil analisis data yang didapatkan bahwa rata-rata durasi fase baseline 5,273 menit dan fase intervensi 6,3375 menit. Berdasarkan hasil analisis data dapat disimpulkan bahwa pembelajaran proyek berpengaruh terhadap konsentrasi anak ADHD.
Implementasi Fitur Kelas Virtual TVSekolah dalam mengembangkan kecerdasan visual spasial pada Anak Usia Dini di SPS Negeri Abdi Praja Cilincing
Authors: Muhasim Sahlia , Yuli Herlina  , Fatmi Cahyani  , Windari Kartika  , Sri Watini  
Published: August 2023

This research will be carried out in May-June 2023 at SPS Negeri Bale Play Abdi Praja The problem found in this study is the lack of special visual intelligence skills in children aged 4-5 years at SPS Negeri Bale Play Abdi Praja. With the role of virtual classes in improving spatial visual intelligence in children aged 4-5 years. The success rate is very significant after the School TV program in improving special visual intelligence in children aged 4-5 years at SPS Negeri Bale Play Abdi Praja. Through qualitative descriptive research methods and data collection through observation, documentation and interviews, the role of the virtual classroom is so great in developing special visual intelligence in early childhood. With results in the second cycle of 66,6 %, namely 10 successful children from 15 students.It can be seen that thedevelopment is not as expected conducteda study in the fourth cycle with a result of 86.6%, thus based on the results achieved in the fourth cyclthe class action research in this study was considered successful in developing spatial visual harmony through virtual classes on School TV.
ABSTRAK
Penelitian ini dilaksanakan pada bulan Mei -Juni 2023 di SPS Negeri Bale Bermain Abdi Praja masalah yang ditemukan pada penelitian kali ini,adalah kurangnya kemampuan kecerdasan visual special pada anak usia 4-5 tahun di SPS Negeri Bale Bermain Abdi Praja .Dengan peran virtual class dalam meningkatkan kecerdasan visual spasial pada anak usia 4-5tahun .Tingkat keberhasilan sangat signifikan setelah adanya program TV Sekolah dalam meningkatkan Kecerdasan visual special pada anak usia 4-5 tahun di SPS Negeri Bale Bermain Abdi Praja .Melalui metode penelitian PTK (Penelitian Tindakan Kelas )dan pengumpulan data melalui observasi, dokumentasi dan wawancara maka peran Kelas virtual begitu besar dalam mengembangkan kecerdasan visual spasial anak usia dini. Dengan hasil pada siklus kedua sebesar 66,6 % yaitu 10 anak yang berhasil dari 15 siswa.Sudah dapat dilihat perkembangannya meski belum sesuai yang diharapkan maka peneliti Menyusun rancangan penelitian yang dilanjutkan dengan kegiatan selanjutnya .Siklus ketiga dengan perolehan hasil sebesar 73,3% Dengan demikian setelah dilakukan refleksi maka peneliti melakukan penelitian pad siklus keempat dengan hasil 86,6% dengan demikian berdasarkan hasil yang dicapai pada siklus keempat maka peneliitian tindakan kelas pada penelitian ini dinaggap berhasil dalam Pengembangan kesecradasan visual spasial melalui kelas virtual pada TV Sekolah.
O SABER DOS PACIENTES DO GRUPO “EU LUTO PELA IMUNO BRASIL”1 SOBRE CLASSE HOSPITALAR
Authors: Mol Gerson , Caixeta Juliana , Bezzan Lelia 
Published: August 2023

A Associação Nacional de Pacientes com Doenças Raras “Eu luto pela Imuno Brasil” onde os integrantes se reconhecem como “Imunos”, é reconhecida pela luta pelos direitos humanos de pacientes com imunodeficiências de todo o Brasil. Nesta pesquisa, nosso objetivo foi identificar os saberes de integrantes desse grupo sobre a Educaçao Hospitalar na modalidade Classe Hospitalar. Os Imunos são pacientes crônicos, que muitas vezes, apresentam repetições de quadros sintomatológicos que levam à internação seja pelas características da doença, pelas sequelas ou por falta de tratamento. Para fazer a pesquisa, utilizamos a metodologia qualitativa. Desenvolvemos um questionário eletrônico, cujo link foi disponbilizado no grupo de WhatsApp dos “Imunos” e ficou disponivel por três semanas e a cada sete dias em média, era enviada uma mensagem lembrete. Participaram da pesquisa 25 integrantes do grupo de whatsapp. Todos os participantes tiveram acessao ao Termo de Consentimento Livre e Esclarecido no início do formulário e só prosseguiam nas respostas caso concordassem em participar da pesquisa de forma livre e deliberada, tendo conhecimento que podiam desistir a qualquer momento. O formulário tinha dois caminhos: um para os participantes que já haviam tomado consciencia do termo “Educação Hospitalar” (Grupo 1) e outro para aqueles que nunca tinham tomado conhecimento (Grupo 2). As respostas foram analisadas pela Análise de Conteúdo. Encontramos duas categorias de participantes que foram descritas a partir dos Grupos 1 e 2. Nossas análises apontaram que a maioria dos participantes da pesquisa não conhece o termo, o direito e nem a modalidade Educação Hospitalar. Os poucos integrantes que conhecem a Educação Hospitalar, entendem-na como uma proposta educacional inclusiva, necessária ao acesso de todos os pacientes que dela necessitam; mas, também, que precisa de revisão para que possa atingir aos objetivos da sua criação e estabelecimento no Brasil.