bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sheehan's syndrome misdiagnosed as encephalitis: A case report and literature review
Authors: Yang Xiao‐Yan , Zheng Yong‐Su , Tuo Jin‐Mei , Zhang Hai‐Qing , Xu Zu‐Cai 
Published: March 2023

AbstractA 48‐year‐old female patient was hospitalized for 5 days after a cold. Encephalitis was considered after preliminary history and routine examination, but the patient did not show significant improvement after antiviral treatment. At this time, magnetic resonance imaging indicated pituitary atrophy, and the patient's medical history was assessed. She had a history of postpartum bleeding and amenorrhea 15 years ago. The supplementary examination indicated hormonal abnormalities. These suggested that the patient may have had Sheehan's syndrome (SS). After hormone supplementation treatment for 10 days, her condition improved. This case suggested that in female patients with neuropsychiatric disorders with a history of previous postpartum hemorrhage, attention needs to be paid to screening for SS to improve the related diagnosis and treatment rate.
Circular RNA SLTM as a miR‐421‐competing endogenous RNA to mediate HMGB2 expression stimulates apoptosis and inflammation in arthritic chondrocytes
Authors: Zhang Hua , Xiang XiaoBing , Zhou BenGen , Chen JianFa , Sun YouQiang , Zhang ShuangXiao , Li AiHua , Li Jie 
Published: March 2023

AbstractOsteoarthritis (OA) is the most common age‐related joint disease characterized by chronic inflammation, progressive articular cartilage destruction, and subchondral sclerosis. Accumulating evidence suggests that circular RNAs (circRNAs) play key roles in OA, but the function of circSLTM in OA remains greatly unknown. Therefore, this study focused on interleukin‐1β (IL‐1β)‐treated primary human chondrocytes as well as a rat model to investigate the expression pattern and functional role of circSLTM in OA in vitro and in vivo. CircSLTM and high mobility group protein B2 (HMGB2) were upregulated in IL‐1β‐induced chondrocytes, whereas miR‐421 was downregulated. Knockdown of circSLTM or overexpression of miR‐421 ameliorated IL‐1β‐induced chondrocyte apoptosis and inflammation. The regulatory relationship between circSLTM and miR‐421, as well as that between miR‐421 and HMGB2, was predicted by bioinformatics and then verified by the RNA immunoprecipitation experiment and dual‐luciferase reporter gene assay. Furthermore, silencing of circSLTM increased cartilage destruction and decreased cartilage tissue apoptosis rate and inflammation in a rat model of OA. Taken together, our findings demonstrate the fundamental role of circSLTM in OA progression and provide a potential molecular target for OA therapy.
Activation of peroxydisulfate by thermally‐treated natural siderite to degrade sulfamethazine: performance and mechanism
Authors: Sun Fuwei , Wang Hao , Wang Qiang , Chu Ziyang , Liu Haibo , Chen Tianhu , Chen Dong , Zou Xuehua , Shu Daobing , Wang Hanlin 
Published: March 2023

AbstractCompared with synthetic materials, natural mineral materials have the advantages of low cost and easy availability. In the present study, magnetite was prepared by calcination of natural siderite under an N2 atmosphere and utilized as a heterogeneous material for sulfamethazine (SMT) degradation via peroxydisulfate (PDS) activation. Various characterizations demonstrated that the S600 (siderite calcinated at 600 °C for 1 h) had a high specific surface area (57.18 m2/g) and high electron transfer ability. Under 1 g/L S600 and 1 mM PDS, 99.9% and 50% of SMT (5 mg/L) and TOC were eliminated in 2 h, with a kinetic constant of 0.026 min−1. Increasing the S600 dosage and PDS concentration favored SMT degradation, while inorganic anions and natural organic matter had the opposite effect. Besides this, Electron spin resonance (ESR) analysis and scavenger experiment results demonstrated that hydroxyl radicals (about 62.3%) and sulfate radicals (about 20.2%) played a major role, while Fe(IV) (about 16.5%) played a minor role in SMT degradation. Moreover, various intermediates for SMT degradation were put forward based on the LC–MS/MS results and their toxicity was predicted to decrease. This work provides a vision for water treatment based on natural mineral materials and presents a new idea for the comprehensive utilization of siderite. © 2023 Society of Chemical Industry (SCI).
Development of medicines for rare diseases and inborn errors of metabolism: Toward novel public–private partnerships
Authors: Rosenberg Noa , Stolwijk Nina N. , van den Berg Sibren , Heus Joris J. , van der Wel Vincent , van Gelder Teun , Bosch Annet M. , de Visser Saco J. , Hollak Carla E. M. 
Published: March 2023

AbstractMedicine development for rare diseases, including inborn errors of metabolism (IEMs) is challenging. Many academic innovations fail to reach the patient, either by stranding in the translational stage or due to suboptimal patient access related to pricing or uncertain effectiveness. Expanding and solidifying the role of the academic in public–private partnerships (PPPs) may present an innovative solution to help overcome these complexities. This narrative review explores the literature on traditional and novel collaborative approaches to medicine development for rare diseases and analyzes examples of PPPs, with a specific focus on IEMs. Several academic institutions have introduced guidelines for socially responsible licensing of innovations for private development. The PPP model offers a more integrative approach toward academic involvement of medicine development. By sharing risks and rewards, failures in the translational stage can be mutually absorbed. If socially responsible terms are not included, however, high pricing can impede patient access. Therefore, we propose a framework for socially responsible PPPs aimed at medicine development for metabolic disorders. This socially responsible PPP framework could stimulate successful and accessible medicine development for IEMs as well as other rare diseases if the establishment of such collaborations includes terms securing joint data ownership and evidence generation, fast access, and socially responsible pricing.
Does minimally invasive surgery have a different impact on recurrence and overall survival in patients with pancreatic head versus body/tail cancer?
Authors: Choi Sung Hoon , Kuchta Kristine , Rojas Aram Eduardo , Paterakos Pierce , Talamonti Mark S. , Hogg Melissa E. 
Published: March 2023

AbstractObjectiveThis study sought to investigate the impact of minimally invasive surgery (MIS) on recurrence and overall survival between patients with pancreatic head versus body/tail cancers.MethodsThe risk factors associated with recurrence and long‐term outcomes were analyzed according to tumor location and operative modality.ResultsA total of 288 and 87 patients underwent surgical resection for pancreatic head cancer and body/tail cancer, respectively. The perioperative outcomes and histopathologic results were comparable in open and MIS approach in both head and body/tail groups. There was no difference in local or systemic recurrence patterns and disease‐free and overall survival rates according to primary tumor location and surgical modality. During subgroup analysis by stage; however, patients with stage III pancreatic head cancer in the MIS group had a decreased disease‐free survival compared with those in the open surgery group (p = 0.020). On multivariate analysis, MIS was not a risk factor of total or local recurrences.ConclusionsRecurrence patterns and overall survival rates of patients did not differ according to tumor location and surgical approach. However, patients with stage III pancreatic head cancer in the MIS group showed inferior disease‐free survival relative to patients who underwent open surgery.
Mechanisms of recurrent laryngeal nerve injury in endoscopic thyroidectomy for papillary thyroid carcinoma: A large data from China
Authors: Xu Wei , Teng Changsheng , Ding Guoqian , Zhao Ning 
Published: March 2023

AbstractPurposeTo investigate the mechanisms of recurrent laryngeal nerve (RLN) injury during endoscopic thyroidectomy via breast approach (ET‐BA) in patients with papillary thyroid carcinoma (PTC).MethodsThe records of 416 PTC patients who underwent ET‐BA with intraoperative neural monitoring (IONM) from May 2015 to May 2021 in Beijing Friendship Hospital affiliated to Capital Medical University were retrospectively analyzed.ResultsAll patients were women. Mean age was 37.80 (7.87) years. The ET‐BA was performed in 416 patients. Overall incidence of RLN injury was 4.3% (18 patients). Injury was transient in 13 patients (3.1%) and permanent in five (1.2%). Macroscopic physical changes were apparent in the injured nerve in five patients (27.8%) and postoperative hoarseness or cough after drinking water were present in 11 (61.1%). Two RLN injuries occurred during nerve identification at the RLN laryngeal entry point into the surgical field, 15 during early nerve dissection somewhere between the first 0.5 and 2 cm of the nerve's course through the surgical field, and one occurred distal to 2 cm. The percentage of patients with separation, transection, traction and thermal mechanisms of injury was 27.8%, 22.2%, 22.2%, and 16.7%, respectively. The mechanism of injury was unknown in 11.1%.ConclusionsRLN injury may still occur during ET‐BA despite endoscopic magnification and early nerve identification even when IONM is used. Separation, transection, and traction injuries were the most frequent causes of injury.
Vector‐valued singular integral operators with rough kernels
Authors: Lai Xudong 
Published: March 2023

AbstractIn this paper, we establish a weak‐type (1,1) boundedness criterion for vector‐valued singular integral operators with rough kernels. As applications, we obtain weak‐type (1,1) bounds for the convolution singular integral operator taking value in the Banach space Y with a rough kernel, the maximal operator taking vector value in Y with a rough kernel and several square functions with rough kernels. Here, is a complex interpolation space between a Hilbert space H and a UMD space X.
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications
Authors: Balusamy Sri Renukadevi , Perumalsamy Haribalan , Huq Md. Amdadul , Yoon Tae Hyun , Mijakovic Ivan , Thangavelu Lakshmi , Yang Deok Chun , Rahimi Shadi 
Published: March 2023

AbstractAmong 17 Panax species identified across the world, Panax ginseng (Korean ginseng), Panax quinquefolius (American ginseng), and Panax notoginseng (Chinese ginseng) are highly recognized for the presence of bioactive compound, ginsenosides and their pharmacological effects. P. ginseng is widely used for synthesis of different types of nanoparticles compared to P. quinquefolius and P. notoginseng. The use of nano‐ginseng could increase the oral bioavailability, membrane permeability, and thus provide effective delivery of ginsenosides to the target sites through transport system. In this review, we explore the synthesis of ginseng nanoparticles using plant extracts from various organs, microbes, and polymers, as well as their biomedical applications. Furthermore, we highlight transporters involved in transport of ginsenoside nanoparticles to the target sites. Size, zeta potential, temperature, and pH are also discussed as the critical parameters affecting the quality of ginseng nanoparticles synthesis.
Gain stability improvement of a wideband antenna using an artificial magnetic conductor
Authors: Chenaoui Safia , Mouffok Lila , Hebib Sami , Fattouche Amina , Allane Dahmane , Tedjini Smail 
Published: March 2023

AbstractIn this paper, a novel artificial magnetic conductor (AMC) reflector is proposed for gain stability enhancement of a low‐profile wideband bowtie antenna (operates at C‐band). Two AMC reflectors are investigated: the first one is based on a standard square patch cell while the second one is based on a novel cell geometry called modified cross shape (MCS). The two units' cell geometries are studied and optimized to achieve the desirable performances, namely; low‐profile, wide impedance bandwidth, and gain stability. The proposed antenna structure with 5 × 8 MCS unit cells is fabricated and measured. The results show a significant steady gain compared to similar work in the literature. The fabricated structure presents a low thickness of 0.084 λL (λL is the guided wavelength at the lowest frequency, i.e., 3.94 GHz) with 0.85 dB of gain variation over a wide impedance bandwidth of about 50% (3.94–6.61 GHz).
Optimization and modeling of PEGylated, hydrocortisone‐17‐butryate‐loaded poly(lactic‐co‐glycolic acid) microspheres
Authors: Myers Nathaniel M. , Comolli Noelle K. 
Published: March 2023

AbstractWe propose by surface functionalizing poly(lactic‐co‐glycolic acid) (PLGA) microspheres we can increase bioavailability and therapeutic duration of hydrocortisone‐17‐butyrate delivery for an intra‐articular injection. In this paper, we look at the proof of concept of the design of the microspheres by optimizing a single‐stage oil/water emulsion. Surface‐modified corticosteroid‐loaded PLGA microspheres (MSs) were synthesized via an avidin/biotin system and were characterized via microscopy, and dynamic light scattering. The optimized PLGA MSs were an average of 1.22 µm ± 0.0132 µm with a zeta potential of −23.17 ± 0.97 mV. Hydrocortisone 17‐butyrate was loaded as a model corticosteroid (entrapment efficiency of 71.98%), and release was evaluated for 3 weeks and compared to a bi‐phasic diffusional model. PEGylation was found to significantly alter the biphasic release by reducing the fractional surface desorption (burst release) and maximizing Fickian diffusion controlled extended release. Unmodified homologs showed 2.34 times more surface desorbed drug as compared to their PEGylated form. These studies show that we can develop a corticosteroid loaded MS that is closer to a large nano‐size, with extended release for 3 weeks. The addition of the PEGlyation to the surface also further increases controlled release, therefore, mitigating harmful concentration spikes post‐administration.
Scyllo‐inositol: Transverse relaxation time constant at 3 T and concentration changes associated with aging and alcohol use
Authors: Deelchand Dinesh K. , Eberly Lynn E. , McCarten J. Riley , Hemmy Laura S. , Auerbach Edward J. , Marjańska Małgorzata 
Published: March 2023

AbstractThe goals of this study were to measure the apparent transverse relaxation time constant, T2, of scyllo‐inositol (sIns) in young and older healthy adults' brains and to investigate the effect of alcohol usage on sIns in young and older healthy adults' brains, using proton magnetic resonance spectroscopy (MRS) at 3 T. Twenty‐nine young adults (age 21 ± 1 years) and 24 older adults (age 74 ± 3 years) participated in this study. MRS data were acquired from two brain regions (the occipital cortex and posterior cingulate cortex) at 3 T. The T2 of sIns was measured using a localization by adiabatic selective refocusing (LASER) sequence at various echo times, while the sIns concentrations were measured using a short‐echo‐time stimulated echo acquisition mode (STEAM) sequence. A trend towards lower T2 relaxation values of sIns in older adults was observed, although these were not significant. sIns concentration was higher with age in both brain regions and was significantly higher in the young when considering alcohol consumption of more than two drinks per week. This study shows that differences in sIns can be found in two distinct regions of the brain across two age groups, potentially reflecting normal aging. In addition, it is important to take into account alcohol consumption when reporting the sIns level in the brain.
Dual‐frequency resonant coil design for low‐γ X‐nuclear and proton magnetic resonance imaging at ultrahigh fields
Authors: Zhang Guangle , Zhu Wei , Li Xin , Zhu Xiao‐Hong , Chen Wei 
Published: March 2023

AbstractLow‐γ X‐nuclear MRS and imaging have played a key role in studying metabolism and physiopathology, especially at ultrahigh fields. We design and demonstrate a novel and simple dual‐frequency RF resonant coil that can operate at both low‐γ X‐nuclear and proton frequencies. The dual‐frequency resonant coil comprises an LC coil loop and a tuning‐matching circuit bridged by two short wires of the desired length to generate two resonant modes: one for proton MRI and the other for low‐γ X‐nuclear MRS imaging with a large difference in their Larmor frequencies at ultrahigh fields. The coil parameters for the desired coil size and resonant frequencies can be determined via numerical simulations based on LC circuit theory. We designed, constructed, and evaluated several prototype surface coils and quadrature array coils for 1H and 2H or 17O imaging, with small‐sized (diameter ≤ 5 cm) coils evaluated using a 16.4 T animal scanner, and a large‐sized (15 cm diameter) coil on a 7 T human scanner. All coils could be tuned/matched and driven in the single coil or array coil mode to the resonant frequencies of 1H (698 and 298 MHz), 2H (107 and 45.8 MHz), or 17O (94.7 and 40.4 MHz) for imaging measurements and evaluation at 16.4 and 7 T, respectively. The dual‐frequency resonant coil or array provides adequate detection sensitivity for 1H MRI and excellent performance for low‐γ X‐nuclear MRS imaging applications, and excellent coil decoupling efficiency between the array coils at both resonant frequencies with an optimal geometric overlap. It provides a simple, cost‐effective dual‐frequency RF coil solution to perform low‐γ X‐nuclear MRS imaging for preclinical and human applications, especially at ultrahigh fields.
δ13C as a tool for iron and phosphorus deficiency prediction in crops
Authors: Trevisan Fabio , Tiziani Raphael , Hall Robert D. , Cesco Stefano , Mimmo Tanja 
Published: March 2023

AbstractMany studies proposed the use of stable carbon isotope ratio (δ13C) as a predictor of abiotic stresses in plants, considering only drought and nitrogen deficiency without further investigating the impact of other nutrient deficiencies, that is, phosphorus (P) and/or iron (Fe) deficiencies. To fill this knowledge gap, we assessed the δ13C of barley (Hordeum vulgare L.), cucumber (Cucumis sativus L.), maize (Zea mays L.), and tomato (Solanum lycopersicon L.) plants suffering from P, Fe, and combined P/Fe deficiencies during a two‐week period using an isotope‐ratio mass spectrometer. Simultaneously, plant physiological status was monitored with an infra‐red gas analyzer. Results show clear contrasting time‐, treatment‐, species‐, and tissue‐specific variations. Furthermore, physiological parameters showed limited correlation with δ13C shifts, highlighting that the plants' δ13C, does not depend solely on photosynthetic carbon isotope fractionation/discrimination (Δ). Hence, the use of δ13C as a predictor is highly discouraged due to its inability to detect and discern different nutrient stresses, especially when combined stresses are present.
Adverse metabolic consequences of androgen deprivation therapy (ADT) on Asian patients with prostate cancer: Primary results from the real‐life experience of ADT in Asia (READT) study
Authors: Wong Chris H. M. , Xu Ning , Lim Jasmine , Feng Kuo‐kang , Chan Wayne K. W. , Chan Marco T. Y. , Leung Steven Ch , Chen Dong‐ning , Lin Yun‐zhi , Chiu Peter K. F. , Yee Chi Hang , Teoh Jeremy Y. C. , Huang Chiu‐yuen , Yeoh Wei‐sien , Ong Teng‐aik , Wei Yong , Ng Chi‐fai 
Published: March 2023

AbstractBackgroundAndrogen deprivation therapy (ADT) use in prostate cancer (PCa) has seen a rising trend. We investigated the relationship between ADT and adverse changes in metabolic parameters in an Asian population.MethodsThis is an international prospective multicenter single‐arm cohort yielded from the real‐life experience of ADT in Asia (READT) registry. Consecutive ADT‐naïve patients diagnosed of PCa and started on ADT were prospectively recruited from 2016 and analyzed. Baseline patient characteristics, PCa disease status, and metabolic parameters were documented. Patients were followed up at 6‐month interval for up to 5 years. Metabolic parameters including body weight, lipid profiles, and glycemic profiles were recorded and analyzed.Results589 patients were eligible for analysis. ADT was associated with adverse glycemic profiles, being notable at 6 months upon ADT initiation and persisted beyond 1 year. Comparing to baseline, fasting glucose level and hemoglobin A1c level increased by 4.8% (p < 0.001) and 2.7% (p < 0.001), respectively. Triglycerides level was also elevated by 16.1% at 6th month and by 20.6% at 12th month compared to baseline (p < 0.001). Mean body weight was 1.09 kg above baseline at 18th month (p < 0.001).ConclusionADT was associated with adverse metabolic parameters in terms of glycemic profiles, lipid profiles, and body weight in the Asian population. These changes developed early in the treatment and can persist beyond the first year. Regular monitoring of the biochemical profiles during treatment is paramount in safeguarding the patients' metabolic health.
Antimalarial activity and sensitization of chrysosplenetin against artemisinin‐resistant genotype Plasmodium bergheiK173 potentially via dual‐mechanism of maintaining host P‐glycoprotein homeostasis mediated by NF‐κB p52 or PXR/CAR signaling pathways and regulating heme/haemozoin metabolism
Authors: Wang Lirong , Ji Hongyan , Ni Shanhong , Xu Jinjing , Zhang Yuanyuan , Zhao Xuesong , Wu Xiuli , Tian Jingxuan , Chen Jing 
Published: March 2023

AbstractThis study investigated antimalarial efficacy and sensitization of chrysosplenetin against artemisinin‐resistant Plasmodium berghei K173 and potential molecular mechanism. Our data indicated a risk of artemisinin resistance because a higher parasitaemia% and lower inhibition% under artemisinin treatment against resistant parasites than those in the sensitive groups were observed. Two non‐antimalarial components, verapamil and chrysosplentin, being P‐gp inhibitors, possessed a strong efficacy against resistant parasites but it was not the case for Bcrp inhibitor novobiocin. Artemisinin‐chrysosplenetin combination improved artemisinin susceptibility of resistant P. berghei. Artemisinin activated intestinal P‐gp and Abcb1/Abcg2 expressions and suppressed Bcrp whereas chrysosplenetin reversed them. Resistant parasite infection led to a decreased haemozoin in organs or an increased heme in peripheral bloods compared with the sensitives; however, that in Abcb1‐deficient knockout (KO)‐resistant mice reversely got increased or decreased versus wild type (WT)‐resistant animals. Chrysosplenetin as well as rifampin (nuclear receptor agonist) increased the transcription levels of PXR/CAR while showed a versatile regulation on hepatic and enternal PXR/CAR in WT‐ or KO‐sensitive or ‐resistant parasites. Oppositely, hepatic and enteric NF‐κB p52 mRNA decreased conformably in WT but increased in KO‐resistant mice. NF‐κB pathway potentially involved in the mechanism of chrysosplenetin on inhibiting P‐gp expressions while PXR/CAR play a more complicated role in this mechanism.