bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Ginseng Extract Ginsenoside Rg1 on Mice with Intracerebral Injury
Authors: Zhuang Zixin , Chen Jinman , Xu Hao , Wang Yongjun , Liang Qianqian 
Published: April 2023

Background:
Traditional Chinese medicine has a long history of treating intracerebral injury. The aim of this research is to test the hypothesis that Ginsenoside Rg1 can alleviate brain injury in subarachnoid hemorrhage (SAH) mice.

Methods:
SAH mice were induced by autologous blood injection into cisterna magna, the mortality and neurological function were assessed. Ginsenoside Rg1 was administered continuously for 7 days after SAH. Then, Y-maze test was used to detect the neurological deficits. Brains were harvested to evaluate the neuroinflammation of SAH by immunofluorescence staining and flow cytometry. Cerebral vasospasm was evaluated by hematoxylin-eosin (HE) staining, and neuronal apoptosis was evaluated by TdT-mediated dUTP Nick-End Labeling (TUNEL) staining and HE staining.

Results:
We demonstrate that Ginsenoside Rg1 reduced mortality and improved neurological deficits, reduced inflammatory response, ameliorated cerebral vasospasm, and neuronal apoptosis after SAH.

Conclusion:
Ginsenoside Rg1 can alleviate brain damage after SAH in mice.
Idiopathic calcinosis cutis of the buttocks: A case report and review of the literature
Authors: E Tian-Yu , Yang Xin-Jun , Bi Chen , Xue Feng , Cao Yong-Qian 
Published: April 2023

Rationale:
Calcinosis cutis is a rare skin disease, and idiopathic cases are rarely reported. It is characterized by the deposition of insoluble calcium salts in the skin, subcutaneous tissue, superficial muscles, and tendon sheaths. However, no abnormal changes were found in the bone. In this article, we introduce a case of idiopathic calcinosis cutis of the buttocks with a long course and large lesion area.

Patient concerns:
A 51-year-old male patient was admitted to the hospital with a chief complaint of ‘Due to the discovery of hard nodules with pruritus in the buttocks for 32 years. The patient was a male who was 51 years old. He has been in good health and reported no history of surgery, trauma, infection, metabolic disease, tumor, or other diseases. There was no family history. It is worth noting that the patient has the occupation of driving trucks, which keeps him sedentary.

Diagnoses:
The accurate diagnosis of calcinosis cutis was confirmed by postoperative histopathological examination with many local calcifications and multinucleated giant cells in subcutaneous tissue.

Interventions:
The patient underwent skin lesion excision and autologous skin grafting under general anesthesia. A medium-thickness skin graft from the left lateral thigh was transplanted into the hip operation area, and a bolus tie-over pressure dressing was applied. After the operation, the patient received anti-infection treatment and was advised to rest in the prone position to prevent extrusion of the operation area.

Outcomes:
The postoperative recovery was good, and there was no recurrence after 4 months of follow-up.

Lessons:
The incidence rate of cutaneous calcinosis is not clear. This patient had a large lesion area, long onset time, an invasion of the fat layer, and the onset site was located in the sacrococcygeal region. It is necessary to choose appropriate treatment methods.
Banded versus non-banded sleeve gastrectomy: A systematic review and meta-analysis
Authors: Chaouch Mohamed Ali , Yang Wah , Gouader Amine , Krimi Bassem , Carneiro da Costa Adriano , Pourcher Guillaume , Oweira Hani 
Published: April 2023

Background:
Laparoscopic banded sleeve gastrectomy (LBSG) has been compared to laparoscopic sleeve gastrectomy (LSG) in terms of anthropometric results and postoperative complications, which are controversial. This systematic review and meta-analysis aimed to compare the safety and efficacy of LBSG and LSG.

Methods:
We performed a systematic review with meta-analysis according to preferred reporting items for systematic review and meta-analysis 2020 and assessing the methodological quality of systematic review 2 guidelines. We included studies that systematically searched electronic databases and compared LBSG with LSG conducted until August 10, 2021.

Results:
The literature search yielded 8 comparative studies. Seven hundred forty-three patients were included: 352 in the LBSG group and 391 in the LSG group. LBSG group allowed greater anthropometric parameters (body mass index [BMI] after 1 year (mean difference [MD] = −3.18; 95% CI [−5.45, −0.92], P = .006), %EWL after 1 year (MD = 8.02; 95% CI [1.22, 14.81], P = .02), and %EWL after 3 years (MD = 10.60; 95% CI [5.60, 15.69], P < .001) and similar results with LSG group in terms of operative time (MD = 1.23; 95% CI [−4.71, 7.17], P = .69), food intolerance (OR = 1.72; 95% CI [0.84, 3.49], P = .14), postoperative vomiting (OR = 2.10; 95% CI [0.69, 6.35], P = .19), and De novo GERD (OR = 0.65; 95% CI [0.34, 1.26], P = .2). Nevertheless, major postoperative complications did not differ between the 2 groups.

Conclusions:
This systematic review and meta-analysis comparing LBSG and LSG concluded that banding sleeve gastrectomy (SG) may ensure a lower BMI and %EWL after 1 year of follow-up, and a significant reduction in %EWL after 3 years of follow-up. There is no evidence to support LBSG in vomiting, de novo GERD, food intolerance, or operative time.
Efficacy and safety of acupuncture in the treatment of stroke complicated with sleep apnea syndrome: A systematic review and meta-analysis of randomized controlled trials
Authors: Gao Huanyu , Kan Zunqi , Fang Yuqing , Wang Ning , Yan Wenli , Yang Mengqi , Song Yongmei 
Published: April 2023

Background:
stroke patients often have a combination of sleep apnea syndrome, which is an important and modifiable risk factor for stroke prognosis. Acupuncture is one of the measures for sleep apnea syndrome, and it is also widely used in stroke. However, we are concerned that its efficacy and safety in the treatment of stroke with sleep apnea syndrome are not yet clear.

Methods:
This systematic review and meta-analysis was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses schema and was registered with INPLASY (registration number: INPLASY202250113). The following 8 databases were searched: PubMed, Cochrane Library (CENTRAL), Embase, Web of Science, China National Knowledge Infrastructure, Chongqing VIP Information, WanFang Data, and China Biomedical Literature Database limited from the establishment of each database to May 4, 2022. Subject headings, free words, and keywords were used for retrieval. Relevant literature was supplemented by consulting other resources. We assessed the risk of bias in the included studies using the Cochrane risk of bias tool. RevMan 5.4 software (The Cochrane Collaboration, 2020) was used to perform the meta-analysis.

Results:
Six records were included, including a total of 513 participants: 256 in the experimental group and 257 in the control group. The results showed that the total effective rate (relative risk = 1.23, 95% confidence interval (CI): 1.13, 1.34, P < .00001), apnea-hypopnea index (mean difference (MD) = −8.39, 95% CI: −9.19, −7.59, P < .00001), Epworth Sleepiness Scale score (MD = −1.59, 95% CI: −2.66, −0.52, P = .004), minimal oxygen saturation (MD = 4.99, 95% CI: 3.5, 6.47, P < .00001), longest duration of apnea (MD = −7.47, 95% CI: −8.97, −5.97, P < .00001), longest duration of apnea (MD = −6.48, 95% CI: −8.60, −4.35, P < .00001), and S100β levels (standard mean difference = −1.52, 95% CI: −1.87, −1.18, P < .00001) were better in the experimental group than in the control group. Simultaneously, the effect of reducing the neuron-specific enolase level in the experimental group was comparable to that in the control group (MD = -3.40, 95% CI: −9.08, 2.29, P = .24).

Conclusions:
Acupuncture can improve the clinical symptoms and related laboratory indicators for sleep apnea syndrome in patients with stroke. More high-quality trials remain urgently needed.
Impact of sentinel lymph node assessment on the outcomes of patients with advanced endometrial cancer: A meta-analysis
Authors: Yao Huiyi , Luo Ruiwen , Tong Ruoyi , Wei Yanwen , Zheng Kaiteng , Hu Xiangdan 
Published: April 2023

Background:
Sentinel lymph node (SLN) assessment is used to treat early endometrial cancer; however, its application in advanced endometrial cancer remains controversial. Therefore, we assessed the effects of SLN assessment and lymphadenectomy (LND) on the prognosis (survival rate and primary outcome) of patients with advanced endometrial cancer.

Methods:
Pertinent studies were selected from PubMed, Embase, Web of Science, and the Cochrane Library until March 19, 2022. Relevant studies were strictly screened according to the inclusion and exclusion criteria. Data from the included studies were extracted and their quality was evaluated. Then RevMan5.4 software was used for the meta-analysis.

Results:
Four retrospective studies were included, which enrolled 7181 patients; 492 were treated with SLN and 6689 with LND. In terms of overall survival, there was no significant difference between the 2 groups (odds ratio = 1.14, 95% confidence interval: 0.92–1.41, I
2 = 0%, P = .39).

Conclusions:
SLN assessment is an alternative to LND as a treatment modality for advanced endometrial cancer.
A leading author of meta-analysis does not have a dominant contribution to research based on the CJAL score: Bibliometric analysis
Authors: Chow Julie Chi , Ho Sam Yu-Chieh , Chien Tsair-Wei , Chou Willy 
Published: April 2023

Background:
There have been nearly 200 thousand meta-analysis articles indexed by web of science (WoS) since 2013. To date, a bibliometric analysis of leading authors of meta-analyses that contribute to the field has not been conducted. Analyzing trend patterns in article citations and comparing individual research achievements (IRAs) are required following the extraction of meta-analysis articles. Using trend analysis, this study aims to verify the hypotheses that; The leading author has a dominant research achievement and; Recent articles that deserve worth reading can be identified.

Methods:
In the WoS collection, we identified the top 20 authors with the most articles related to meta-analysis. Using coword analysis, 2882 articles were collected to cluster author collaborations and identify the top 3 authors with the highest weighted centrality degrees. Based on the CJAL (category, journal raking by impact factor, authorship, and L-index on article citation) score and absolute advantage coefficient (AAC), we compared the IRAs and identified the author who dominated the field significantly beyond the next 2 authors. In WoS collection, coword analysis was used to highlight the characteristics of research domains for the top authors contributing to meta-analyses. The selection of articles that deserve reading is based on a temporal heatmap.

Results:
The top 2 authors were Young–Ho Lee (South Korea), Patompong Ungprasert (U.S.), and Brendon Stubbs (US) with CJAL scores of 240.71, 230.99, and 240.71, respectively. Based on the weak dominance coefficient (AAC = 0.49 < 0.50), it is evident that the leading meta-analysis author does not possess a significant dominant position over the next 2 leading authors in IRAs. Coword analysis was used to illustrate the characteristics of the 3 authors research domains. The 3 articles worth reading were selected based on a trend analysis of the last 4 years using the temporal heatmap.

Conclusion:
A coword analysis of meta-analysis studies identified 3 leading authors. There was no evidence that 1 author possessed a dominant position due to the lower AAC (=0.49 < 0.50) for the leading author. As we have demonstrated in this study, the CJAL score and the AAC can be applied to many bibliographical studies in the future.
Efficacy of acupuncture therapy for stable chronic obstructive pulmonary disease: A systematic review and meta-analysis
Authors: Fan Su , Zhang Zhenyu , Wang Qinglin 
Published: April 2023

Background:
Acupuncture therapy (AT) is a widely used, alternative medicine in China. AT is an effective treatment for many diseases, but its efficacy in stable chronic obstructive pulmonary disease (COPD) remains controversial. Therefore, we performed the present meta-analysis to evaluate the efficacy of AT in stable COPD patients.

Methods:
Randomized controlled trials (RCTs) for AT efficacy in stable COPD patients were searched in literature databases from the inception to December 31, 2021. Pooled effect sizes of outcome measurements with respect to lung function (forced vital capacity [FVC], forced expiratory volume in 1 second [FEV1], FEV1 in predicted value [FEV1%], FEV1/FVC), quality of life (St. George respiratory questionnaire [SGRQ]), exercise capacity (6-minute walking distance [6MWD]) and effective rate were estimated by calculating weighted mean difference (WMD) or odds ratio (OR) with corresponding 95% confidence interval (95% CI), respectively, by a random-effect model.

Results:
A total of 28 RCTs with 2130 COPD patients were included. AT group had significant improvement in FVC (WMD = 0.29 L, 95% CI: 0.22–0.36, P < .001), FEV1 (WMD = 0.33 L, 95% CI: 0.23–0.43, P < .001), FEV1% (WMD = 3.30%, 95% CI: 3.30–4.64, P < .001), FEV1/FVC (WMD = 5.45%, 95% CI: 4.41–6.49, P < .001), 6MWD (WMD = 45.48 m, 95% CI: 28.21–62.16, P < .001), SGRQ (WMD = −7.79, 95% CI: −12.34 to −3.24, P < .001), and a higher effective rate (OR = 3.71, 95% CI: 2.50–5.52, P < .001) compared to the control group. Subgroup analysis stratified by comparison model (AT combined with other treatments vs other treatments, AT alone vs sham AT) and treatment duration (≥8 weeks, <8 weeks) also showed more improvement in AT arm than control arm without significant between-subgroup difference. Adverse events were reported in a few studies and only mild reactions were observed.

Conclusion:
AT is effective in improving lung function, quality of life and exercise capacity, and can be used as an adjunctive treatment in patients with stable COPD.
A large pericardial cyst mimicking a unilateral pleural effusion: A case report
Authors: Li Minfang , Yang Chunfeng , Li Jinshuai , Jia Dan , Wang Yaqiong , Xie Wei , Wang Jinlin 
Published: April 2023

Rationale:
Pericardial cysts are a rare benign disorder with a variable clinical presentation depending on their size and location. The diagnosis of pericardial cysts is usually based on imaging examinations. The definitive treatment is surgical resection.

Patient concern:
A 36-year-old woman presented with progressive left-sided chest pain and exertional dyspnea, with symptoms resembling pleural effusion.

Diagnoses:
The patient was diagnosed with a pericardial cyst based on imaging and video-assisted thoracoscopic surgery (VATS).

Intervention:
VATS was performed.

Outcomes:
The patient’s symptoms improved after successful removal of the pericardial cyst. Follow-up chest computed tomography exhibited no evidence of recurrence.

Lessons:
Clinicians should include pericardial cysts in the differential diagnosis of pseudopleural effusion. VATS is a feasible and safe method to treat symptomatic and large pericardial cysts.
Middle ear cholesteatoma resection under general anesthesia in patients with congenital methemoglobinemia: A case report
Authors: Cai Zenghua , Shao Yu , Wu Yu 
Published: April 2023

Rationale:
Congenital methemoglobinemia is a rare cyanosis cause that can be manifested in affected individuals. We report a case of congenital methemoglobinemia after middle ear cholesteatoma resection under general anesthesia.

Patient concerns:
The primary concern of the patient is to safely perform cholesteatoma resection of the middle ear to reduce the pain associated with years of surgery and to survive the perioperative period.

Diagnoses:
Congenital methemoglobinemia type 1.

Interventions:
The patient underwent general anesthesia and cholesteatoma resection of the middle ear.

Outcomes:
The patient successfully underwent cholesteatoma resection in the middle ear under general anesthesia and went through the perioperative period smoothly, and successfully returned to society.

Lessons:
For patients requiring general anesthesia complicated with rare methemoglobinemia, we improve the awareness of crisis and make comprehensive preparation and monitoring, learn the pathophysiological mechanism related to the disease, so as to protect the operation of methemoglobin patients under general anesthesia.
Surgical approaches to the adrenal gland
Authors: Sada Alaa , McKenzie Travis J. 
Published: April 2023

Purpose of review
Review the literature on the surgical management of adrenal diseases, highlighting the various surgical approaches and their respective pros and cons.

Recent findings
Minimally invasive adrenalectomy is commonly used for small and benign adrenal tumors, whereas open adrenalectomy is preferred for larger tumors and primary adrenal malignancy. Although minimally invasive adrenalectomy results in shorter recovery and fewer complications compared with open, the latter offers better oncologic outcomes in the setting of primary adrenal malignancy. Adrenalectomy is performed transabdominally or retroperitoneoscopically, both yielding equivalent results and recovery. Traditional laparoscopic or robotic equipment can be utilized for either minimally invasive approach. Subtotal adrenalectomy may be appropriate for patients with genetically associated pheochromocytoma to preserve cortical function and reduce the risk of adrenal insufficiency. However, the potential benefits of sparing adrenal function must be weighed against the risk of recurrence.

Summary
Adrenalectomy is becoming increasingly common worldwide. For benign and small adrenal tumors, minimally invasive adrenalectomy is generally considered the standard approach, while open adrenalectomy is preferred for primary adrenal malignancy and larger tumors. Subtotal adrenalectomy may be appropriate for patients with bilateral adrenal pheochromocytoma, as it can reduce the need for lifelong glucocorticoid dependency.
Use of Induction of Labour and Emergency Cesarean Section and Perinatal Outcomes in English Maternity Services: A National Hospital-Level Study
Authors: Gurol-Urganci Ipek , Jardine Jennifer , Carroll Fran , Frémeaux Alissa , Muller Patrick , Relph Sophie , Waite Lara , Webster Kirstin , Oddie Sam , Hawdon Jane , Harris Tina , Khalil Asma , van der Meulen Jan ,   National Ministry and Perinatal Audit Project Team
Published: April 2023

ABSTRACT
Care provided by maternity services requires a fine balance between support for the physiological process of birth and clinical intervention when needed. Yet, clinical guidelines for maternity care vary widely within and between countries. For singleton babies born at term in 149 hospitals of the National Health Service (NHS) in the United Kingdom alone, the rate of induction of labor varied from 16% to 44%, and the overall rate of cesarean delivery (CD) varied from 17% to 35% between April 2016 and March 2017. This suggests a lack of consensus around the indications for interventions, such as induction of labor and emergency CD. The debate often focuses on either the safety of childbirth or the women's experience to deliver good maternity care. The aim of this study was to examine the association between the rates of induction of labor and emergency CD with the risks of stillbirth, neonatal intensive care unit (NICU) admission, and need for mechanical ventilation in neonates born at term.
This was a national study using data collected from electronic maternity records between 2015 and 2017. Included were singleton pregnancies delivered in NHS hospitals providing maternity care. The primary outcomes were stillbirth, NICU admission, and mechanical ventilation.
The entire cohort included 1,131,719 term, singleton births in 131 hospitals. The risks of stillbirth, NICU admission, and need for mechanical ventilation in the baby were 0.15%, 5.4%, and 0.54%, respectively. Between hospitals, the rate of induction of labor ranged from 17.5% to 40.7% (interquartile range, 24.6%–32.1%), and the rate of emergency CD ranged from 5.6% to 17.1% (interquartile range, 9.4%–11.8%). In hospitals with higher induction rates, the risk of adverse perinatal outcomes was lower, but the association was statistically significant only between the rate of induction and rates of stillbirth (P = 0.002) and mechanical ventilation (P = 0.001). For each 5%-point increase in the rate of induction at a hospital, there was a 9% decrease in the risk of stillbirth (odds ratio [OR], 0.91; 95% confidence interval [CI], 3%–15%) and a 14% decrease in the risk of mechanical ventilation (OR, 0.86; 95% CI, 6%–21%). There was no association between the rate of emergency CD and the primary outcomes (all P > 0.05).
In the United Kingdom, the rates of induction of labor and emergency CD varied considerably between hospitals. Those hospitals with higher rates of induction had lower risks of adverse perinatal outcomes, but not for emergency CD.
Artificial Intelligence and Interstitial Lung Disease: Diagnosis and Prognosis
Authors: Dack Ethan , Christe Andreas , Fontanellaz Matthias , Brigato Lorenzo , Heverhagen Johannes T. , Peters Alan A. , Huber Adrian T. , Hoppe Hanno , Mougiakakou Stavroula , Ebner Lukas 
Published: April 2023

Abstract
Interstitial lung disease (ILD) is now diagnosed by an ILD-board consisting of radiologists, pulmonologists, and pathologists. They discuss the combination of computed tomography (CT) images, pulmonary function tests, demographic information, and histology and then agree on one of the 200 ILD diagnoses. Recent approaches employ computer-aided diagnostic tools to improve detection of disease, monitoring, and accurate prognostication. Methods based on artificial intelligence (AI) may be used in computational medicine, especially in image-based specialties such as radiology. This review summarises and highlights the strengths and weaknesses of the latest and most significant published methods that could lead to a holistic system for ILD diagnosis. We explore current AI methods and the data use to predict the prognosis and progression of ILDs. It is then essential to highlight the data that holds the most information related to risk factors for progression, e.g., CT scans and pulmonary function tests. This review aims to identify potential gaps, highlight areas that require further research, and identify the methods that could be combined to yield more promising results in future studies.