bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curcuminoids as Cell Signaling Pathway Modulators: A Potential
Strategy for Cancer Prevention
Authors: Noor Aneeza , Shafi Saimeena , Sehar Nouroz , Qadir Insha , Bilquees  , Rashid Summya , Arafah Azher , Rasool Saiema , Dar Nawab John , Masoodi Mubashir Hussain , Rehman Muneeb U. 
Published: August 2023

Abstract:
Despite substantial advancements in curative modern medicine in the last few
decades, cancer risk and casualty rates have continued to mount globally. The exact reason
for cancer's onset and progression is still unknown. However, skeletal and functional
abnormalities in the genetic code are assumed to be the primary cause of cancer. Many
lines of evidence reported that some medicinal plants can be utilized to curb cancer cell
proliferation with a safe, fruitful, and cost-efficient perspective. Curcuminoid, isolated
from Curcuma longa, have gotten a lot of focus due to their anticancer potential as they
reduce tumor progression, invasion, and dissemination. Further, they modulated signal
transduction routes like MAPK, PI3K/Akt/mTOR, JAK/STAT, and Wnt/β-catenin, etc.,
and triggered apoptosis as well as actuated autophagy in malignant cells without altering
the normal cells, thus preventing cancer progression. Besides, Curcuminoid also regulate
the function and expression of anti-tumor and carcinogenic miRNAs. Clinical studies also
reported the therapeutic effect of Curcuminoid against various cancer through decreasing
specific biomarkers like TNF-α, Bcl-2, COX-2, PGE2, VEGF, IκKβ, and various cytokines
like IL-12p70, IL-10, IL-2, IFN-γ levels and increasing in p53 and Bax levels.
Thus, in the present review, we abridged the modulation of several signal transduction
routes by Curcuminoids in various malignancies, and its modulatory role in the initiation
of tumor-suppressive miRNAs and suppression of the oncogenic miRNAs are explored.
Additionally, various pharmacokinetic approaches have been projected to address the
Curcuminoids bioavailability like the use of piperine as an adjuvant; nanotechnology-
based Curcuminoids preparations utilizing Curcuminoids analogues are also discussed.
Medicinal Plant-derived Phytochemicals in Detoxification
Authors: Bjørklund Geir , Cruz-Martins Natália , Goh Bey Hing , Mykhailenko Olha , Lysiuk Roman , Shanaida Mariia , Lenchyk Larysa , Upyr Taras , Rusu Marius Emil , Pryshlyak Antonina , Shanaida Volodymyr , Chirumbolo Salvatore 
Published: August 2023

Abstract:
The average worldwide human life expectancy is 70 years, with a significantly higher value in Western societies. Many modern diseases are not associated with premature mortality but with a decreased quality of
life in aged patients and an excessive accumulation of various toxic compounds in the human body during life.
Today, scientists are especially interested in finding compounds that can help increase a healthy lifespan by detoxifying the body. Phytotherapy with specific approaches is used in alternative medicine to remove toxins
from the body. Worldwide, research is conducted to identify medicinal plant-derived molecules that, with few
or no side effects, may protect the liver and other organs. This review provides updated information about the
detoxification process, the traditional and modern use of the most effective medicinal plants, their active
metabolites as detoxifying agents, and the mechanisms and pathways involved in the detoxification process.
Among medicinal plants with substantial detoxifying properties, a major part belongs to the Asteraceae family
(Silybum marianum, Cynara scolymus, Arctium lappa, Helichrysum species, Inula helenium, and Taraxacum officinale). The most widely used hepatoprotective phytocomponent is silymarin, a standardized extract from the Silybum marianum seeds containing a mixture of flavonolignans. Many polysaccharides, polyphenols, and terpenoids have a detoxifying effect. Overall, scientific data on medicinal plants used in phytotherapeutic practice worldwide provides an understanding and awareness of their efficacy in detoxification.
Applications of Flow Chemistry in Total Synthesis of Natural Products
Authors: Majhi Sasadhar 
Published: August 2023

Abstract:
A vital driving force for chemists to discover novel synthetic protocols is the improvement
of more effective synthetic technologies and sustainable methodologies. This is
associated with the development of innovative research that stimulates the creative reevaluating
of known conceptions. Currently, these robust methodologies, as well as green
synthetic procedures, have been designed for the total synthesis of secondary metabolites.
Flow chemistry and flow photochemistry have emerged as powerful tools to promote valuable
transformations in the total synthesis of natural products as key step(s). Flow chemistry development
offers many merits over a traditional batch format, namely a round-bottom flask.
The advantages of this green tool comprise waste minimization, simple scale-up, reduction of
reaction time, safety betterment as, well as energy and cost efficiency. Flow chemistry comprises
a fascinating prospect for the synthesis of promising organic molecules and bioactive complex natural products
as it represents a suitable modern synthetic technology for the improvement of sustainable chemistry. Continuous
flow chemistry is an assembly of chemical processes carried out in continuous flowing streams. Compared to
conventional organic synthesis, it is a process that strengthens technology and is superior in enhancing and scaling
up synthesis, accurately controlling reaction rate, and providing the desired products with maximum yields. In the
past and likely in the future natural products and their analogue will continue to deliver the stimulation for drug
discovery and development programs. Total synthesis of natural products is very useful to synthesize natural products
in the laboratory as many secondary metabolites are available in low quantities from their sources of origin.
So, this review wishes to cover the brilliant applications of flow chemistry in the total synthesis of natural products
in the field of novel technological advances.
Neuroprotection of Thioredoxin1 in the Brain
Authors: Noriega-Navarro Roxana , Martínez-Tapia Ricardo J. , Osornio-Hernández Juan L. , Landa-Navarro Lucia , Xinastle-Castillo Luis O. , Landa Abraham , Navarro Luz 
Published: August 2023

Abstract:
Thioredoxin1 (Trx1) is a ubiquitous antioxidant protein that regulates the cell's redox status.
Trx1's thiol redox activity protects neurons from various physiological processes that cause
neuronal damage and neurodegeneration, including oxidative stress, apoptosis, and inflammation.
Several studies have found that direct or indirect Trx1 regulation has neuroprotective effects in the
brain, protecting against, preventing, or delaying neurodegenerative processes or brain traumas.
This review focuses on the term neuroprotection, Trx1 localization, and expression in the brain, as
well as its modulation concerning its neuroprotective effect in both animal and clinical models of ischemia,
hypoxia, hemorrhage, traumatic brain injury, epilepsy, Alzheimer's disease, and Parkinson's
disease.
Machine Learning and Pharmacogenomics at the Time of Precision
Psychiatry
Authors: Del Casale Antonio , Sarli Giuseppe , Bargagna Paride , Polidori Lorenzo , Alcibiade Alessandro , Zoppi Teodolinda , Borro Marina , Gentile Giovanna , Zocchi Clarissa , Ferracuti Stefano , Preissner Robert , Simmaco Maurizio , Pompili Maurizio 
Published: August 2023

Abstract:
Traditional medicine and biomedical sciences are reaching a turning point because of the
constantly growing impact and volume of Big Data. Machine Learning (ML) techniques and related
algorithms play a central role as diagnostic, prognostic, and decision-making tools in this field. Another
promising area becoming part of everyday clinical practice is personalized therapy and pharmacogenomics.
Applying ML to pharmacogenomics opens new frontiers to tailored therapeutical
strategies to help clinicians choose drugs with the best response and fewer side effects, operating with
genetic information and combining it with the clinical profile. This systematic review aims to draw up
the state-of-the-art ML applied to pharmacogenomics in psychiatry. Our research yielded fourteen papers;
most were published in the last three years. The sample comprises 9,180 patients diagnosed with
mood disorders, psychoses, or autism spectrum disorders. Prediction of drug response and prediction
of side effects are the most frequently considered domains with the supervised ML technique, which
first requires training and then testing. The random forest is the most used algorithm; it comprises several
decision trees, reduces the training set's overfitting, and makes precise predictions. ML proved effective
and reliable, especially when genetic and biodemographic information were integrated into the
algorithm. Even though ML and pharmacogenomics are not part of everyday clinical practice yet, they
will gain a unique role in the next future in improving personalized treatments in psychiatry.
Targeting Histone 3 Variants Epigenetic Landscape and Inhibitory
Immune Checkpoints: An Option for Paediatric Brain Tumours Therapy
Authors: Meenakshi Sarasa , Maharana Krushna Ch , Nama Lokesh , Kumar Vadla Udaya , Dhingra Sameer , Ravichandiran Velayutham , Murti Krishna , Kumar Nitesh 
Published: August 2023

Abstract:
Despite little progress in survival rates with regular therapies, which do not provide complete
care for curing pediatric brain tumors (PBTs), there is an urgent need for novel strategies to
overcome the toxic effects of conventional therapies to treat PBTs. The co-inhibitory immune checkpoint
molecules, e.g., CTLA-4, PD-1/PD-L1, etc., and epigenetic alterations in histone variants, e.g.,
H3K27me3 that help in immune evasion at tumor microenvironment have not gained much attention
in PBTs treatment. However, key epigenetic mechanistic alterations, such as acetylation, methylation,
phosphorylation, sumoylation, poly (ADP)-ribosylation, and ubiquitination in histone protein, are
greatly acknowledged. The crucial checkpoints in pediatric brain tumors are cytotoxic T lymphocyte
antigen-4 (CTLA-4), programmed cell death protein-1 (PD-1) and programmed death-ligand 1 (PDL1),
OX-2 membrane glycoprotein (CD200), and indoleamine 2,3-dioxygenase (IDO). This review
covers the state of knowledge on the role of multiple co-inhibitory immunological checkpoint proteins
and histone epigenetic alterations in different cancers. We further discuss the processes behind these
checkpoints, cell signalling, the current scenario of clinical and preclinical research and potential futuristic
opportunities for immunotherapies in the treatment of pediatric brain tumors. Conclusively,
this article further discusses the possibilities of these interventions to be used for better therapy
options.
A Concise Review on Therapeutic Potential, Phytochemistry and Traditional
Applications of Safed Musli (Chlorophytum borivilianum)
Authors: Dhakad Prashant K. , Mishra Raghav , Mishra Isha , Sharma Vikram 
Published: August 2023

Background:
In traditional medicine, Safed musli is a very popular herb. Natural sex tonics like Chlorophytum borivilianum (C. borivilianum) are effective in alleviating sexual disorders. Local healers in indigenous communities of India mostly use it for ethnic medicine. The circulation of blood is one of the functions it improves to enhance strength and energy. Since ancient times, the tuber roots of the plant Safed musli have been used to treat weakness and male impotency.

Objective:
The aim of this work is to bridge the scientific evidence with the pharmacological, phytochemical, and folkloric claims reported in different sources belonging to C. borivilianum.

Methods:
To build the manuscript, a detailed literature review was carried out by thoroughly analyzing globally accepted scientific research databases.

Results:
Safed musli is widely recognized for its efficacy in addressing male impotence. The abundant presence of phytoconstituents, particularly saponins, contributes to the nutritional and multifaceted therapeutic significance of C. borivilianum.

Conclusion:
The current review enlightens the pharmacotherapeutic potential of C. borivilianum, comprising its origin and distribution, botany, proximate composition, method of enhancing seed germination, pathology, phytochemistry, pharmacology, and traditional uses. The scope for future research is provided by the present review, which also furnishes a gateway for filling the existing gap in its various aspects of investigation.
Low Viscosity Ionic Liquids as Novel Dopants in Poly (Methyl
Methacrylate) Polymer Electrolyte: Detailed Photoelectrochemical
Studies
Authors: Bajaj Yashika , Latif Famiza Abdul , Masri M.N , Yahya M.Z.A , Singh Pramod K. 
Published: August 2023

Background:
A propitious electrolyte for supercapacitors, solid polymer electrolytes (SPEs) has been used because of their flexibility and highly conducting good electrode-electrolyte interface. Poly (methyl methacrylate) (PMMA)-based SPEs have acknowledged extensive interest due to their integrity in synthesis, good mechanical stability, low binding energy, low mass density with ionic salts, and magnificent charge carrier mobility. Interesting ionic liquids show their novelty towards conductivity enhancement and suppressing crystallinity i.e. acts as a plasticizer as well as an ionic source. Due to these advantageous properties, ionic liquids (ILs) seem to be a good player in developing highly efficient electrochemical devices.

Method:
To overcome the low ionic conductivity (σ) and poor mechanical stability. ILs assume to be novel candidates. This review is toward defining the role of ILs as plasticizers, not as a solvent.

Result:
Due to the widespread applicability of these ILs, we focus our review on taking a common example of polyether i.e. PMMA using the solution cast method. Electrical and electrochemical are also discussed in detail.

Conclusion:
On the the basis of electrical and photoelectrochemical performance reported in this article, we can assure the scientific community that ILs can act as a potential candidate like a plasticizer for highly efficient electrochemical devices.
Influence of Vitamin D Level on Inflammatory and Prognostic Markers in
COVID-19 - A Retrospective Study
Authors: Singh Sunil Kumar , Singh Shruti , Kumar Rajesh , Rana Proteesh , Sharma Ajay , Karwasra Ritu , Kesharwani Prashant , Sahebkar Amirhossein 
Published: August 2023

Objective:
The ongoing pandemic of severe acute respiratory syndrome coronavirus
2019 (SARS-CoV-2) has caused an immense public health crisis worldwide. Emerging evidence
has suggested that inflammatory response plays a critical role in the pathogenesis and prognosis
of the disease. As vitamin D can modulate the immune system, this study has been designed to
correlate vitamin D with inflammatory and prognostic markers in COVID-19 patients.

Methods:
The present study is a retrospective study examining the relationship between vitamin
D levels and inflammatory markers in the COVID-19 disease. COVID-19 patients who were investigated
for vitamin D, ferritin, D-dimer, C-reactive protein (CRP), and procalcitonin (PCT)
level were only included. The patients were divided into hypovitaminosis D, and normal vitamin
D. Correlation and logistic regression analyses were carried out to identify the strength and association
of hypovitaminosis D with inflammatory markers in COVID-19 disease.

Results:
The hypovitaminosis D group had significantly higher inflammatory markers compared
to the normal vitamin D group. The correlation between hypovitaminosis D and procalcitonin
was negative (r = -0.433), with a strong and significant association (p = 0.002). The correlation
between hypovitaminosis D, CRP, and ferritin was weak and insignificant. The logistic regression
between hypovitaminosis D and procalcitonin established a significant regression equation,
leading to a significant linear model.

Conclusion:
This study concludes that patients with hypovitaminosis D should be treated with
vitamin D therapy to reduce the severity of COVID-19 disease.
Impact of the COVID-19 Health Crisis on Key Populations at Higher Risk for, or Living With, HIV or Hepatitis C Virus and People Working With These Populations: Multicountry Community-Based Research Study Protocol (EPIC Program)
Authors: Delabre Rosemary M , Di Ciaccio Marion , Lorente Nicolas , Villes Virginie , Castro Avila Juliana , Yattassaye Adam , Bonifaz César , Ben Moussa Amal , Sikitu Ingrid-Zaïre , Khodabocus Niloufer , Freitas Rosa , Spire Bruno , Veras Maria Amélia , Sagaon-Teyssier Luis , Girard Gabriel , Roux Perrine , Velter Annie , Delpech Valérie , Ghosn Jade , Riegel Lucas , Rojas Castro Daniela 
Published: August 2023

Background
Information concerning the impact of the COVID-19 health crisis on populations most affected by HIV and hepatitis C virus (HCV; or key populations [KP]), and those working with these populations in community settings, is limited. Community-based organizations working in the field of HIV and viral hepatitis are well placed to identify and meet the new needs of KP owing to the health crisis.

Objective
This study aims to describe the development and implementation of an exploratory and descriptive multicountry, community-based research program, EPIC (Enquêtes Pour évaluer l’Impact de la crise sanitaire covid en milieu Communautaire), within an international network of community-based organizations involved in the response to HIV and viral hepatitis. The EPIC program aimed to study the impact of the COVID-19 health crisis on KP or people living with HIV or HCV and people working with these populations at the community level (community health workers [CHWs]) and to identify the key innovations and adaptations in HIV and HCV services.

Methods
A general protocol and study documents were developed and shared within the Coalition PLUS network. The protocol had a built-in flexibility that allowed participating organizations to adapt the study to local needs in terms of the target population and specific themes of interest. Data were collected using surveys or interviews.

Results
From July 2020 to May 2022, a total of 79 organizations participated in the EPIC program. Across 32 countries, 118 studies were conducted: 66 quantitative (n=12,060 among KP or people living with HIV or people living with HCV and n=811 among CHWs) and 52 qualitative (n=766 among KP or people living with HIV or people living with HCV and n=136 among CHWs).

Conclusions
The results of the EPIC program will provide data to describe the impact of the health crisis on KP and CHWs and identify their emerging needs. Documentation of innovative solutions that were put into place in this context may help improve the provision of services after COVID-19 and for future health crises.

International Registered Report Identifier (IRRID)
DERR1-10.2196/45204
Secular Trends in Gastric and Esophageal Cancer Attributable to Dietary Carcinogens From 1990 to 2019 and Projections Until 2044 in China: Population-Based Study
Authors: Guo Hui-Xiao , Wang Qi , Wang Can , Yin Qing Chen , Huo Hua Zhi , Yin Bing Hua 
Published: August 2023

Background
Little is known about trends in or projections of the disease burden of dietary gastric and esophageal cancer (GEC) in China.

Objective
We aim to report GEC deaths and disability-adjusted life years (DALYs) from 1990 to 2019, predict them through 2044, and decompose changes in terms of population growth, population aging, and epidemiological changes.

Methods
We retrieved dietary GEC data from the Global Burden of Disease (GBD) online database and used joinpoint regression and age-period-cohort models to analyze trends in dietary GEC deaths and DALYs from 1990 to 2019 in China. We used a Bayesian age period cohort model of integrated nested Laplace approximations to predict the disease burden of GEC through 2044 and obtained the estimated population of China from 2020 to 2050 from the Global Health Data Exchange website. Finally, we applied a recently developed decomposition method to attribute changes between 2019 and 2044 to population growth, population aging, and epidemiological changes.

Results
The summary exposure values and age-standardized rates decreased significantly from 1990 to 1999, with percentage changes of –0.06% (95% CI –0.11% to –0.02%) and –0.05% (95% CI –0.1% to –0.02%), respectively. From 1990 to 2019, for dietary esophageal cancer, the percentage change in age-standardized mortality rate (ASMR) was –0.79% (95% CI –0.93% to –0.58%) and the percentage change in age-standardized DALY rate (ASDR) was –0.81% (95% CI –0.94% to –0.61%); these were significant decreases. For dietary stomach cancer, significant decreases were also observed for the percentage change in ASMR (–0.43%, 95% CI –0.55% to –0.31%) and the percentage change in ASDR (–0.47%, 95% CI –0.58% to –0.35%). In addition, data from both the joinpoint regression and annual percentage change analyses demonstrated significantly decreasing trends for the annual percentage change in ASMR and ASDR for GEC attributable to dietary carcinogens. The overall annual percentage change (net drift) was –5.95% (95% CI –6.25% to –5.65%) for dietary esophageal cancer mortality and –1.97% (95% CI –2.11% to –1.83%) for dietary stomach cancer mortality. Lastly, in 2044, dietary esophageal cancer deaths and DALYs were predicted to increase by 192.62% and 170.28%, respectively, due to age structure (121.58% and 83.29%), mortality change (76.81% and 92.43%), and population size (–5.77% and –5.44%). In addition, dietary stomach cancer deaths and DALYs were predicted to increase by 118.1% and 54.08%, with age structure, mortality rate change, and population size accounting for 96.71% and 53.99%, 26.17% and 3.97%, and –4.78% and –3.88% of the change, respectively.

Conclusions
Although the predicted age-standardized rates of mortality and DALYs due to dietary GEC show downward trends, the absolute numbers are still predicted to increase in the next 25 years due to rapid population aging in China.
Urgensi Legalitas Usaha, Literasi Keuangan dan Fintech dalam Memulai Bisnis pada Masa New Normal
Authors: Nursansiwi Dwi Arini , Wardah Sofiati , Armiani Armiani 
Published: August 2023

In conducting and running a business, human resources are needed who are able to understand and update the progress and developments of the times. This requires business legality to obtain legal certainty for the business being run, financial literacy to provide an understanding of the benefits of financial reports for business continuity, fintech to expand business networks and be able to meet customer needs. This PKM program provides education to MSME actors about the importance of business legality, financial literacy and the use of fintech in the sustainability of their business, as well as providing training and assistance in making NIB online and preparing simple financial reports. The PKM method used is service learning with 3 stages (preparation, service, and reflection). This PKM program was carried out at the Lombok Beach hotel in December 2022 for 5 days with participants as prospective MSME actors and MSME actors. The results show that in order to be competitive, MSME actors need business legality (NIB), HR who understand financial reports and the benefits of financial reports for the sustainability of their business, apply accounting records to their business transactions, and use and utilize fintech in their business transactions. The government can support and facilitate the needs of MSMEs in their working area.
Keywords: Business Legality, Financial Literacy, Fintech, New Normal