bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defining the Relationship Between Ovarian Adult Granulosa Cell Tumors and Synchronous Endometrial Pathology: Does Ovarian Tumour Size Correlate With Endometrial Cancer?
Authors: Tokalioglu Abdurrahman Alp , Oktar Okan , Sahin Mustafa , Ozturk Cagatayhan , Erdogan Ozgur , Yildirim Hande Esra Koca , Ucar Yesim , Kilic Fatih , Ersak Burak , Yalcin Necim , Ozmen Fatma , Alci Aysun , Bas Sevda , Gorgulu Goksen , Selcuk Ilker , Ucar Gokhan , Kocak Ozgur , Cakir Caner , Kilic Cigdem , Comert Gunsu Kimyon , Ureyen Isin , Toptas Tayfun , Narin Mehmet Ali , Tasci Tolga , Taskin Salih , Boran Nurettin , Ozdal Bulent , Sanci Muzaffer , Uncu Dogan , Korkmaz Vakkas , Tekin Ozlem Moraloglu , Ustun Yaprak , Ortac Fırat , Turan Taner 
Published: September 2023

Abstract
Objective:The main feature of adult granulosa cell tumours (AGCT) is their capacity to secrete hormones, with nearly all of them capable of synthesizing oestradiol. Endometrial pathology is caused granulosa cell-produced oestrogen. The primary goal of this study is to identify synchronised endometrial pathologies, particularly endometrial cancer, in AGCT patients who had undergone a hysterectomy. The secondary objective is to define the factors related to synchronised endometrial cancer in AGCT.
Materials and Methods: The study cohort comprised retrospectively of 316 AGCT patients from ten tertiary gynaecological oncology centres. AGCT surgery consisted of bilateral salpingo-oophorectomy, hysterectomy, peritoneal cytology, omentectomy and the excision of any suspicious lesion. Endometrial hyperplasia was categorised as simple hyperplasia without atypia, complex hyperplasia without atypia, complex hyperplasia with atypia or endometrial intraepithelial neoplasia (EIN). The median tumour size value was used to define the relationship between tumour size and endometrial cancer. The relationship between each value and endometrial cancer was evaluated.
Results:EIN or hyperplasia with complex atypia was detected in 7.7% of patients and endometrial cancer in 3.2% of patients. The relationship between tumour size and endometrial cancer was evaluated by taking the tumour size as a cut-off value of 150 mm. Four patients with a tumour size of ≤150 mm (3.2%), and four patients with a tumour size >150 mm (12.1%) had endometrial cancer. (p=0.036). Tumour size was statistically significant in relation to endometrial cancer in menopausal AGCT patients.
Conclusion: Our present study determined that 7.3% of patients had complex hyperplasia with atypia or EIN, and 3.1% of patients had endometrial carcinoma. During the menopausal period, endometrial cancer risk was 4.5%. The study revealed that the likelihood of developing endometrial cancer increased to 12% from 3.2% when the size of the tumour was >150 mm in menopausal patients.
Phenol degradation and Cu2+ dissolution behaviors of Cu/Al2O3 catalyzed advanced oxidation processes in water
Authors: Zhang Wumin , Zhuang Huimin , Guo Yu , Chi Hua , Ding Qiuyue , Wang Lu , Xi Yanyan , Lin Xufeng 
Published: September 2023

Abstract
Catalytic wet peroxide oxidation (CWPO) has become an important deep oxidation technology for organics removal in wastewater treatments. Supported Cu-based catalysts belong to an important type of CWPO catalyst. In this paper, two Cu catalysts, namely, Cu/Al2O3-air and Cu/Al2O3-H2 were prepared and evaluated through catalytic degradation of phenol. It was found that Cu/Al2O3-H2 had an excellent catalytic performance (TOC removal rate reaching 96%) and less metal dissolution than the Cu/Al2O3-air case. Moreover, when the organic removal rate was promoted at a higher temperature, the metal dissolution amounts was decreased. Combined with hydroxyl radical quenching experiments, a catalytic oxidation mechanism was proposed to explain the above-mentioned interesting behaviors of the Cu/Al2O3-H2 catalyst for CWPO. The catalytic test results as well as the proposed mechanism can provide better guide for design and synthesis of good CWPO catalysts.
Radiation source terms analysis and the classification of radioactive waste for the decommissioning of the first HWRR nuclear reactor in China
Authors: Guo Yaping , Nie Peng , Li Ruizhi , Zhang Lijun , Zhao Zelong 
Published: September 2023

Abstract

Nuclear reactor will face the problem of decommissioning due to the high radioactivity of their components and the consideration of environmental safety when the operating period ends. The Heavy Water Research Reactor (HWRR) is the first large-scale research reactor to be decommissioned in China. The second phase of decommissioning involves the highly radioactive reactor block, so the source terms of the main reactor internals need to be evaluated. Based on the operating history, the complex three-dimensional geometry, materials and other information of HWRR reactor, this paper calculates and analyzes the activity of radionuclides of reactor internals. The results indicate that 14C, 54Mn, 55Fe, 60Co, 63Ni, and 152Eu are the main radioactive nuclides. The total activity of radioactive nuclides was 2.36E + 15Bq at the safe shutdown time at the end of 2007, 4.27E + 13Bq at the end of 2021, and 1.83E + 13Bq at the end of 2025. In addition, the ratio of the theoretical activity values to the sampling results is within 2.5 times and is conservative. The inner shell, outer shell, cooling water tank, sand layer, and heavy concrete shielding layer are all low-level waste. These data can provide reference for the preparation of the second phase of HWRR reactor decommissioning and the subsequent disposal of radioactive waste.
Testing the critical waters: replication, further refinement and validation of the Critical Social Justice Attitudes scale
Authors: Lahtinen Oskari 
Published: September 2023

Abstract
Objectives: The present study set out to refine and further validate a scale for assessing critical social justice attitudes as well as replicate results from a previous study. This study assessed the reliability, factor structure, model fit, and both convergent and divergent validity of the scale. The study examined the prevalence of critical social justice attitudes in different subpopulations and probed the scale’s correlations with well-being and other variables.
Methods: Participants were a nationwide sample (n = 5030) of people aged 15-84. 5 new candidate items for the scale were introduced and after analyses, 4 were included in the final version of the critical social justice attitudes scale (CSJAS; 11 items).
Results: The final CSJAS scale had high reliability and good model fit as well as convergent and divergent validity. Overall, the study sample rejected critical social justice propositions, with strong rejection from men but cautious support from women (gender difference: d = 1.16). CSJAS was correlated with depression, anxiety, and (lack of) happiness, but not more so than being politically left was.
Conclusions: The Critical Social Justice Attitude Scale was successfully constructed and validated. It had good reliability and model fit.
Digital Support for Wellbeing: Addressing COVID-19-Related Mental Health Challenges in a Developing Country via Web-Based Telehealth
Authors: Ghiasi Nasrin , Babashahi Mashallah , Saeidnia Hamid Reza , Lotfata Aynaz , Karajizadeh Mehrdad , Hassanzadeh Mohammad 
Published: September 2023

Abstract
Background
Mental disorders pose a significant global challenge, particularly accentuated by the escalated prevalence during the COVID-19 pandemic outbreak. In addressing this critical issue, the utilization of web-based telehealth systems emerges as a promising solution to provide essential healthcare services to individuals grappling with mental disorders. In light of this, the primary objective of this study is to share the experience of designing and developing a web-based telehealth system tailored for deployment within a developing country.
Method
Using a three-phase model, we conducted interviews with 8 clinical psychologists and 8 general psychologists in the Concept Identification phase, extracting content to alleviate COVID-19-related mental health burdens. In the System Design phase, we collaborated with 24 experts recruited from social media to develop a final prototype for a web-based telehealth system's user interface. The third phase, Pre- and Post-Implementation Assessments, engaged 120 participants. Using the COVID-19 Stress Scale (CSS), we measured stress levels before and after participation. Data analysis employed comprehensive statistical tests, calculating Standard Deviation and Mean for an overview, and conducting analytical tests (independent sample t-test, one-way ANOVA, Tukey's post hoc test) for deeper insights.
Results
Depression, drug use, stress, anxiety, and sleep problems emerged as shared concerns among all participating psychologists. Data indicated an initial stress score of 128 for participants before engaging with the web-based telehealth. Subsequently, stress scores progressively decreased over quarters: 85 in the first, 44 in the second, and 62 in the third. Significantly, repeated measures analysis of variance highlighted a substantial stress reduction within the COVID-19-affected group.
Conclusion
Traditional in-person mental health care encounters barriers in these situations. In contrast, web-based telehealth presents a solution that overcomes geographical constraints, reduces travel complexities, and eases the financial burden of seeking care. Moreover, it offers increased flexibility in appointment scheduling, enhancing the overall convenience of mental health support. A key advantage of web-based telehealth is its potential to maintain a continuum of care for individuals managing mental health challenges.
Development of Occlusal Canting Identifying Tool: Verification, Reliability and Validation Assessment
Authors: Alhuwaish Hessah A. , Almoammar Khalid A. , Fakhouri Abdulaziz S. 
Published: September 2023

Abstract
Introduction: Occlusal cant (OC) is a malocclusion trait that lacks accurate clinical assessment methods. The occlusal canting identifying tool (OCIT) was invented and patented as a clinical tool to accurately identify and quantify the degree of maxillary OC. This study aimed to 1) develop a prototype of the OCIT, 2) verify the functionality of the OCIT and 3) assess the validity and reliability of the OCIT.
Materials and Methods: A patented OCIT design was revised, and the dimensions were finalized, followed by a three-dimensional conceptual prototype design that was reviewed and approved by the inventors. Verification was performed using a digital angle gauge to determine the accuracy of the bubble level as well as the angle between the bite plate and the protractor. For laboratory validation, 40 orthodontists measured the simulated OC at (0°, 2°, 4°, 6° and 8°) on five phantom heads using the OCIT. A reliability assessment of the tool was performed in three occasions by one orthodontist using the same laboratory settings.
Results: The OCIT was prototyped from a medical-grade stainless steel alloy (316 L). Verification assessment revealed that the accuracy error of the bubble level (0.316° ± 0.028°) was statistically significant but clinically insignificant, while that of the angle between the bite plate and protractor (0.100° ± 0.050°) was statistically insignificant. Validation assessment showed high validity of the OCIT with no statistically significant difference between the OCIT and the reference values, having more errors in identifying smaller OC degrees compared to larger OC degrees. The intraclass correlation coefficient indicated the high reliability of the OCIT.
Conclusion: The OCIT was verified and proven to be a valid and reliable clinical tool that accurately evaluates the degree of OC.
Dual Intra-articular injections of corticosteroid and hyaluronic acid are more effective than corticosteroid alone for ankle osteoarthritis
Authors: Woo Inha , Lee Jung-Min , Hyeon Jo Seong , Baek Jongyoon , Park Chul Hyun 
Published: September 2023

Abstract
An intra-articular corticosteroid injection is commonly administered to relieve pain for ankle osteoarthritis (OA). Corticosteroid effects are short-lived, whereas, hyaluronic acid (HA) has longer effects. We hypothesized that intra-articular injections of corticosteroid and HA would be more effective than corticosteroid alone. A randomized controlled trial was decided to investigate the hypothesis. 135 patients with OA were gathered to an intra-articular corticosteroid injection group (CS group, n = 61) or dual HA plus corticosteroid injection group (CS + HA group, n = 74). The CS group received a corticosteroid injection of 1 ml once, and the CS + HA group received 2 ml of HA and 1 ml corticosteroid on the first week, followed by 2 ml of HA on the second and third weeks. Clinical evaluations were performed before injection (baseline), 6 and 12 weeks after first injections. The Ankle Osteoarthritis Scale (AOS) was used as the primary outcome measure, and the Visual Analog Scale (VAS), Short Form health survey (SF-36), and complications used as secondary outcomes. The CS + HA group had better primary outcomes than the CS group. Remarkable secondary outcomes improvements were obtained in both groups. No complications were reported. We conclude that the corticosteroid and HA combination injection is more effective in relieving pain for ankle OA than corticosteroid alone.
Unraveling the adverse Impacts of Nano-scale Carbon Exposure on Nitrogen Metabolism during Early Seedling Establishment in Zea mays L. Roots
Authors: zhang di , Sun Qi , Zhang Ruixue , Lu Lei , Wang Junwei , Fang Xiaojie 
Published: September 2023

Abstract
Background and aims
Elucidating the relationship between extraneous nano-scale carbon properties and the metabolomic response of early Zea mays L. seedling establishment roots is crucial to reveal nano-carbon regulation and nutrient transport mechanisms.
Methods
Herein, humic acid and graphite nanoplatelets represented typical organic and inorganic morphologies of nano-scale carbon. We used equimolar exogenous carbon inputs (0.4, 2, 4 mol C kg−1) to investigate the regulation of nitrogen metabolism using LC-MS, phenotype and physiology of root, nitrogen metabolism-related enzyme activities and endogenous hormones.
Results
Our findings demonstrate that humic acid and graphite nanoplatelets promote root thickening and branching. The most prominent effects on root vitality, injury intensity, and total active absorption area were observed with 2 mol C kg−1 graphite nanoplatelets and 4 mol C kg−1 humic acid. The trend of nitrogen metabolism activity remained consistent, involving the assimilation of NR and NiR and the primary synergistic regulation of GO and GOGAT. Notably, 2 mol C kg−1 graphite nanoplatelets induced the dynamic and selective up-regulation of pyruvic acid and down-regulation of tyramine and methyl phosphate, resulting in changes in energy metabolism and a small subset of amino acid metabolism. 4 mol C kg−1 humic acid resulted in the down-regulation of the amino acids (L-asparagine, pyruvic acid, L-aspartic acid, L-glutamine, fumaric acid), which are involved in nitrogen metabolism-related processes.
Conclusion
Overall, these findings highlight additional graphite nanoplatelets regulated nitrogen assimilation and protein synthesis pathways to improve nitrogen availability. Nano-carbon showed a potential role in reprogramming the agricultural traits.
Brief psychotic disorder caused by areca nut use: a case report
Authors: Li Sixun , Li Zhe , Li Zhixiong , Chen Juan , Wang Feng , Ou Ying , Huang Yi 
Published: September 2023

Abstract
Background: Areca Nut (AN) is the fourth most commonly abused drug after nicotine, ethanol, and caffeine, due to its psychoactive properties provided by bioactive substances. Although previous studies have demonstrated AN’s anxiolytic-like activity and potential benefits in ameliorating symptoms of depression and schizophrenia, there remains limited awareness regarding its association with brief psychotic disorder.
Case Presentation: This case report presents the clinical profile of a 30-year-old male patient with a history of betel nut chewing for the past 2 years, who exhibited sudden onset delusions, hallucinations, and disorganized speech and behavior upon increasing the dosage of betel nut consumption. The patient displayed a positive response to antipsychotic treatment, and symptoms resolved upon discontinuation of betel nut consumption. However, one month after discharge, the patient experienced a recurrence of auditory hallucinations upon resuming betel nut chewing. Through counseling and support, the importance of abstaining from betel nut use and maintaining medication compliance was emphasized, resulting in no recurrence of psychotic symptoms during the six-month follow-up.
Conclusion: This case report highlights the potential role of betel nut in triggering brief psychotic disorder, especially when the chewing dosage is abruptly increased. It underscores the importance of considering betel nut as a potential precipitant of acute psychiatric disorders in clinical settings.
Gender-based association between high-density lipoprotein cholesterol and adverse outcomes after coronary artery bypass grafting
Authors: Namin Sara Monrazeri , Moradi Ali , Tavolinejad Hamed , Farahani Ali Vasheghani , Jalali Arash , Pashang Mina , Sadeghian Saeed , Bagheri Jamshid , Mansourian Soheil , Mehrani Mehdi , Hosseini Kaveh , Rashedi Sina , Tajdini Masih 
Published: September 2023

Abstract
Background
High-density lipoprotein cholesterol (HDL-C) is shown to be an independent protective factor against coronary artery diseases (CAD). Yet there are limited studies focusing on the association between HDL-C and coronary artery bypass graft (CABG) surgery outcomes.
Hypothesis
Low levels of HDL-C are associated with higher incidence of adverse outcomes in patients undergoing CABG.
Methods
This registry-based study included 17,772 patients who underwent elective isolated CABG between 2007 and 2017. Participants were assigned into low and optimal HDL-C groups based on serum HDL-C levels at admission and were followed for one year after surgery. Cox proportional hazard models were performed to evaluate the association between HDL-C levels and incidence of mortality as well as major adverse cardiovascular and cerebrovascular events (MACCE), while adjusting for potential confounders. Moreover, participants were stratified based on gender and the association was also investigated in each subgroup separately.
Results
No significant difference was found between the groups regarding incidence of both mortality and MACCE, after adjusting with IPW [HR (95%CI): 1.109 (0.815–1.509) and HR (95% CI): 1.192 (0.995–1.428), respectively]. According to the gender-based subgroup analysis, low HDL-C group exhibited higher MACCE incidence solely in the male subgroup, after adjusting with IPW.
Conclusion
The association between perioperative HDL-C level and incidence of MACCE during 1-year post-CABG surgery in the male subgroup suggests HDL-C level as a possible prognostic factor in this population. Further studies are warranted to clarify the role of HDL-C level in predicting the prognosis of patients undergoing CABG.
Treatment of Sanders type II and III calcaneal fractures involving posterior superior calcaneal body with lateral straight “three-window” incision combined with a microvariable-angle locking plate
Authors: xu jinglei , Chang Ning , bai xue , xu chenyang , Ma Xianzhong 
Published: September 2023

Abstract

Background: We compared the therapeutic outcomes of patients operated on via the three-window lateral straight approach (TWLSA) and sinus tarsi approach (STA) with a microvariable-angle locking plate for the treatment of Sanders type II and III calcaneal fractures involving the posterior superior calcaneal body.
Methods: We reviewed 100 patients with Sanders II or III calcaneal fractures involving the posterior superior calcaneal body from February 2018 to February 2021. Sixty patients were treated with the TWLSA, and 40 were treated with the STA. The Böhler angle, Gissane angle, height, width, and length were evaluated preoperatively, immediately after surgery and at the last follow-up. The operation time and fluoroscopy times were recorded. The American Orthopedic Foot and Ankle Society (AOFAS) scorewas used to evaluate foot function and record complications.
Results: Pre- and postoperative radiologic parameters were significantly different in both groups (both P＜0.05). Neither the postoperative nor the last follow-up radiologic parameters differed significantly between the 2 groups (both P > 0.05). The operation time and fluoroscopy times in the TWLSA group were significantly lower than those in the STA group (both P<0.05). At the last follow-up, the AOFAS scores averaged 92 (83-99) inthe TWLSA group and 91 (81-99) in the STA group, but this difference was not statistically significant. Sural nerve injury occurred in 6 cases of TWLSA and 4 cases of STA, and this difference was not statistically significant. Incision infections did not occur in either group.
Conclusions: Compared with the STA, the TWLSA afforded comparable radiological results, clinical outcomes and complications for the treatment of Sanders II and III calcaneal fractures involving the posterior superior calcaneal body but reduced operation time and fluoroscopic times.
Landscape epidemiology to understand the distribution of Amblyomma spp. (Acari: Ixodidae) in the state of Pará, Eastern Amazon, Brazil
Authors: Araújo Izabela Mesquita , Martins Thiago Fernandes , Nascimento Kelly Karoline Gomes do , Barbieri Amália Regina Mar , Guimarães Ricardo José de Paula Souza e , de Oliveira Ana Cristina Mendes , Labruna Marcelo Bahia , Abel Ísis 
Published: September 2023

Abstract
This study investigated the diversity and abundance of questing ticks in three forest fragments in the state of Pará, Brazil. A model to predict species distribution for all territory of the state was developed. Ticks were collected using the flannel drag technique, flannel leggings and a CO2 attractive trap. Species richness and relative abundance were calculated and a non-metric multidimensional scaling was used to assess the similarity across ticks species collected in areas. The potential distribution of tick species was predicted using the MaxEnt software. In total, 2921 ticks were captured, distributed in eight species: Amblyomma varium, Amblyomma humerale, Amblyomma naponense, Amblyomma cajennense sensu stricto, Amblyomma oblongoguttatum, Amblyomma ovale, Amblyomma calcaratum and Amblyomma pacae. Non-metric multidimensional scaling indicated that humans and domestic animals living around fragments do not need to enter the wild environment to be exposed to these ticks. Five species, A. cajennense s.s., A. calcaratum, A. humerale, A. naponense and A. varium, were used to predict spatial distribution in the state of Pará. These species seem to be distributed in Pará regions that presents types of climate classified as Af or Am: northeast, metropolitan area of Belém, Marajó, and the upper southeastern state. This study also showed that most ticks have a predilection for lower areas. This study presents the first ecological data required to understand the spatial distribution of ticks of the Amblyomma genus in the state of Pará. However, further studies are necessary to investigate especially southwest Pará state and lower amazon.