bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Depression and Anxiety in Women with Polycystic Ovary Syndrome (PCOS) and Associated Factors: A Cross-Sectional Study
Authors: Keeratibharat Pattra , Sophonsritsuk Areepan , Saipanish Ratana , Wattanakrai Penpun , Anantaburana Makaramas , Tantanavipas Siriluk 
Published: August 2023

Abstract

Background
Polycystic ovary syndrome (PCOS) is a common gynecological problem for women of reproductive age. Depression and anxiety are common conditions that occur in women with PCOS and have an impact on mental well-being. However, there is a lake of data on their prevalence and its associated factors in the Thai population. This cross-sectional study aimed to evaluate the prevalence of depression and anxiety among women with PCOS and identify the factors associated with depression and anxiety in women with PCOS, as well as their impact on mental well-being.
Methods
A total of 260 women aged 15 to 40 years diagnosed with PCOS based on the Rotterdam criteria were included in the study. Physical examinations were conducted, and participants completed Hospital Anxiety and Depression Scale (HADS) and Thai version WHO-Five Well-Being Index (WHO-5 Thai) questionnaires to assess depression, anxiety, and mental well-being, respectively.
Results
The prevalence of depression, anxiety, and poor mental well-being among women with PCOS was found to be 3.8%, 11.9%, and 16.9%, respectively. Poor mental well-being (odds ratio [OR] 26.85, 95% confidence interval [CI]: 4.4–164.0; p = < 0.001), snoring (OR 18.16, 95% CI: 2.74-120.61; p = 0.003), moderate to severe hirsutism (OR 13.05, 95% CI: 1.66-102.64; p = 0.015), and anxiety (OR 7.02, 95% CI: 1.28–38.42; p = 0.025) were identified as factors associated with depression in women with PCOS. Having children (OR 17.84, 95% CI: 4.39–72.52; p = < 0.001) and hirsutism (OR 2.75, 95% CI: 1.18–6.37; p = 0.018) were found to be relative factors for anxiety in women with PCOS.
Conclusion
The present study demonstrated that PCOS is linked to depression and anxiety, leading to a significant impact on mental well-being. Hirsutism was identified as a key factor associated with depression and anxiety in women with PCOS. Based on these findings, the present study suggests that screening for depression and anxiety should be conducted in women with PCOS who present with hirsutism.
Disability-related inequalities in the prevalence of loneliness across the lifespan: trends from Australia, 2003 to 2020
Authors: Bishop Glenda M. , Llewellyn Gwynnyth , Kavanagh Anne M. , Badland Hannah , Bailie Jodie , Stancliffe Roger , Emerson Eric , Fortune Nicola , Aitken Zoe 
Published: August 2023

Abstract
Background
Experiencing loneliness can be distressing and increasing evidence indicates that being lonely is associated with poor physical and mental health outcomes. Cross-sectional studies have demonstrated that people with disability have increased risk of experiencing loneliness compared to people without disability. However, we do not know if these inequalities have changed over time. This study investigated the prevalence of loneliness for people with disability in Australia annually from 2003 to 2020 to examine whether disability-related inequalities in loneliness have changed over time, and disaggregated results for subgroups of people with disability by age group, sex, and disability group.
Methods
We used annual data (2003–2020) from the Household, Income and Labour Dynamics in Australia Survey. Loneliness was measured by a single question assessing the subjective experience of loneliness. For each wave, we calculated population-weighted age-standardised estimates of the proportion of people experiencing loneliness for people with and without disability. We then calculated the absolute and relative inequalities in loneliness between people with and without disability for each wave. Analyses were stratified by 10-year age groups, sex, and disability group (sensory or speech, physical, intellectual or learning, psychological, brain injury or stroke, other).
Results
From 2003 to 2020, the prevalence of loneliness was greater for people with disability, such that people with disability were 1.5 to 1.9 times more likely to experience loneliness than people without disability. While the prevalence of loneliness decreased for people without disability between 2003 to 2020, the prevalence of loneliness did not decrease for people with disability during this period. Inequalities in loneliness were more substantial for people with intellectual or learning disabilities, psychological disability, and brain injury or stroke.
Conclusion
This study confirms that people with disability have increased risk of loneliness compared to people without disability. We add to the existing evidence by demonstrating that disability-related inequalities in loneliness have persisted for two decades in Australia without improvement. Our findings indicate that addressing inequalities in loneliness for people with disability is a critical public health concern given that loneliness is associated with a wide range of poor health outcomes.
StableDNAm: Towards a Stable and Efficient Model for Predicting DNA Methylation Based on Adaptive Feature Correction Learning
Authors: Zhuo Linlin , Wang Rui , Fu Xiangzheng , Yao Xiaojun 
Published: August 2023

Abstract
Background: DNA methylation, instrumental in numerous life processes, underscores the paramount importance of its accurate prediction. Recent studies suggest that deep learning, due to its capacity to extract profound insights, provides a more precise DNA methylation prediction. However, issues related to the stability and generalization performance of these models persist.
Results: In this study, we introduce an efficient and stable DNA methylation prediction model. This model incorporates a feature fusion approach, adaptive feature correction technology, and a contrastive learning strategy. The proposed model presents several advantages. First, DNA sequences are encoded at four levels to comprehensively capture intricate information across multi-scale and low-span features. Second, we design a sequence-specific feature correction module that adaptively adjusts the weights of sequence features. This improvement enhances the model’s stability and scalability, or its generality. Third, our contrastive learning strategy mitigates the instability issues resulting from sparse data. To validate our model, we conducted multiple sets of experiments on commonly used datasets, demonstrating the model’s robustness and stability. Simultaneously, we amalgamate various datasets into a single, unified dataset.
The experimental outcomes from this combined dataset substantiate the model’s robust adaptability.
Conclusions: Our research findings affirm that the StableDNAm model is a general, stable, and effective instrument for DNA methylation prediction. It holds substantial promise for providing invaluable assistance in future methylationrelated research and analyses.
Exploring Differences in Fertility Based on Experience of Intimate Partner Violence in Afghanistan
Authors: Ghahfarokhi Mehri Shams 
Published: August 2023

Abstract
Background
Intimate Partner Violence (IPV) is a primary manifestation of gender inequality in society and poses a significant obstacle to achieving global reproductive health goals due to its direct impact on women's access to healthcare and health outcomes. Despite the concerted efforts of global organizations, Afghanistan still experiences high levels of fertility. This paper aims to investigate differences in fertility based on the experience of violence and to answer the question of whether violence is a problem for fertility.
Methods
The data employed in this investigation were acquired from the 2015 Afghanistan Population and Health Survey. A discrete-time survival analysis model was employed to estimate the impact of violence on both probability and fertility patterns.
Results
The study findings indicate that women who have undergone IPV may have different reproductive outcomes compared to those who have not. Specifically, women with IPV experience may have slightly higher fertility rates and shorter birth intervals for certain birth orders. However, the differences between the two groups are generally small.
Conclusions
The study findings underscore the importance of policies and programs that tackle both intimate partner violence and reproductive health simultaneously. Addressing gender inequality and violence against women is crucial for improving reproductive health outcomes in Afghanistan. The outcomes of this study emphasize the necessity of integrating comprehensive and holistic approaches to reproductive health that recognize the complex interplay between violence and reproductive outcomes.
Strong-field photoelectron holography in the subcycle limit
Authors: Tsendsuren Khurelbaatar , Heo Jaewuk , Kim Dong Eon , Lai XuanYang , Yu ShaoGang , Liu Xiaojun 
Published: August 2023

Abstract

Strong-field photoelectron holography (SFPH) is promising for the study of electron dynamics and structure in atoms and molecules, with superior spatiotemporal resolution compared to conventional electron and X-ray diffractometry. However, the application of SFPH has been hindered by intercycle interference from multicycle fields. Here, we address this challenge by employing a near-single-cycle field to suppress the intercycle interference. We observed and separated two distinct holographic patterns for the first time. Our measurements allow us not only to identify the Gouy phase effect on electron wavepackets and holographic patterns but also to correctly extract the internuclear separation of the target molecule from the holographic pattern. Our work leads to a leap jump from theory to application in the field of SFPH-based ultrafast imaging of molecular structure.
Successful implantation of a leadless pacemaker in a patient after tricuspid valve replacement following cardiac tumor removal: a case report and literature review
Authors: Zou Qi , Chang Peng , Jiang Cheng , Lin Pengyang , Sun Shougang 
Published: August 2023

Abstract
Introduction
Intravenous-cardiac leiomyomatosis (ICL) is a rare condition characterized by the presence of leiomyomatous tumors within the cardiac venous system. Tricuspid valve replacement (TVR) is often required when the tricuspid valve (TV) is difficult to repair. However, complications such as atrioventricular block (AVB) can arise from damage to the cardiac conduction system during TVR surgery. This case highlights the successful implantation of a leadless pacemaker (LP) in a patient with advanced AVB following cardiac tumor removal combined with bioprosthetic TVR.
Case Presentation
Our patient, a 49-year-old female with a history of hysteromyoma and myomectomy, presented with sudden syncope and was diagnosed with ICL. Cardiac tumor removal was performed, and due to the inability to repair the TV, TVR with a bioprosthesis was undertaken. Postoperative assessments, including Electrocardiogram (ECG) and transthoracic echocardiography (TTE), revealed no significant abnormalities in electrocardiographic activity or structural changes in the heart. The patient was readmitted in November after surgery with syncope and was diagnosed with third-degree AVB, likely attributed to the TVR surgery. Considering the patient's age, medical history, and quality of life needs, the decision was made to proceed with implantation of a leadless pacemaker (LP), Micra, 11 months after cardiac tumor removal combined with bioprosthetic TVR.
Conclusion
This case represents the first reported instance of LP implantation in a patient following cardiac tumor removal combined with bioprosthetic TVR. The procedure was successful, and short-term follow-up indicated the safety and effectiveness of LP in treating advanced AVB after bioprosthetic TVR. These findings highlight the potential of LP as a treatment option for similar cases in the future.
Developing wideband antenna based on the metamaterial and dielectric silicon load for THz spectrum
Authors: Sharma Sachin , Ebrahimi Sepideh , Zarrabi Ferdows B. 
Published: August 2023

Abstract
THz antenna with wide bandwidth and high Q-factor is interesting for various application including 6G application and THz sensing and controlling the surface current of the antenna is known as a technique for bandwidth enhancement. The slot antenna with metasurface is a good candidate for this aim. In this research, we have suggested a multilayer slot antenna with metamaterial load to provide wide bandwidth which covers the 0.38 to 0.57 THz with bandwidth of 40%. The metamaterial loads make various paths for the current on the surface of the antenna that makes possible achieving the wider bandwidth. The proposed antenna has gain of 4 dBi. To achieve higher bandwidth the dielectric silicon (Si) load is placed over the metasurface. The result shows that the height and form of the Si element can impact the bandwidth of the antenna. To modify the results of the antenna, the shape, height and width of the dielectric load over the antenna is examined. The antenna bandwidth is enhanced more than 100% and it covers 0.371 to 0.616 THz with 49% bandwidth. The proposed antenna is simulated with full wave time domain technique of FIT (finite integrated technique).
Comparison of two advanced bipolar tissue sealer/dividers for laparoscopic ovariectomy in dogs: Articulating Enseal G2 versus Ligasure Maryland device
Authors: Driessen Floor , Marrero Javier Deniz , Grinwis Guy Cornelis Maria , Nimwegen Sebastiaan Alexander van 
Published: August 2023

Abstract
Background
Advanced bipolar tissue sealer/dividers provide the most reliable and efficient means of tissue dissection and blood vessel ligation in laparoscopic surgery and techniques are continuously improved. In veterinary practice cost-effectiveness is of major impact, leading to re-use of instruments designed and sold for single use. Two high-end devices were evaluated and compared in a highly standardized laparoscopic ovariectomy procedure in dogs in the present study: The new generation Ligasure Maryland Sealer/Divider (LMSD) with improved atraumatic curved jaw shape for delicate tissue handling and dissection and non-stick nanocoating, and the new-generation Articulating Enseal G2 (AENG2) with several proclaimed features improving surgical performance, including articulation of the forceps tip; improved tissue compression during sealing; unique offset electrode configuration; and specific nanoparticle coating minimizing thermal spread and tissue sticking. Twenty-one client-owned dogs admitted for elective laparoscopic ovariectomy were randomly assigned to one of two groups: ovariectomy using AENG2 on the left ovary and LMSD in the right ovary or vice-versa. Procedural video recordings were used to assess ovarian ligament fat score, smoke formation, occurrence of bleeding, and excision duration. Excised tissues were examined histopathologically and collateral thermal damage was scored in three anatomic zones: suspensory ligament, vascular pedicle, and uterine junction. Tissue sealers were used repeatedly following standardized cleaning protocol with instrument washing machine and Ethylene Oxide gas sterilization and the number of uses until device failure was recorded.
Results
Excision times were significantly increased for AENG2 (median 01:35 min) compared to LMSD (median 01:00 min). Minor hemorrhage from incomplete sealing occurred in 3 sites in 2 patients (2x AENG2, 1x LMSD) and was not significantly different between groups. Smoke production as scored on videos and thermal tissue damage scores on histopathology also did not differ between AENG2 and LMSD. Both vessel sealers could be re-used repeatedly.
Conclusion
AENG2 provides a good alternative to LMSD in laparoscopic ovariectomy, with only minor differences in measured variables. Subjectively, the articulating feature of AENG2 did not improve surgical performance in laparoscopic ovariectomy and the use of LMSD appeared more straight-forward. However, differences in operating these devices may be subject to personal preference.
Juvenile Dermatomyositis: Association between Nail Fold Capillary End Row Loops Area Under the Curve and Disease Damage Indicators
Authors: Khojah Amer , Morgan Gabrielle , Klein-Gitelman Marisa S. , Pachman Lauren M. 
Published: August 2023

Abstract
Background

Juvenile Dermatomyositis (JDM) is a rare autoimmune disease characterized by skin and muscle inflammation. The loss of nail fold capillary end row loops (ERL) is evidence of small vessel involvement in JDM. This study aimed to examine the association of ERL over the disease course and evidence of disease damage.

Methods

We analyzed data from 68 initially treatment-naïve JDM children who had been observed for at least five years with multiple ERL density assessments. The JDM disease courses were categorized into monocyclic short, monocyclic long, polycyclic, and chronic. The ERL capillary count was cumulatively evaluated using the area under the curve (AUC) method.

Results

The mean ERL density for the treatment-naive JDM was significantly lower than that of their healthy controls (4.8±1.6 /mm vs. 7.9±0.9 /mm; p <0.0001). The ERL AUC was significantly lower in children with chronic disease course compared to those with monocyclic short (p =0.001) or monocyclic long disease course (p =0.013). JDM patients with lipodystrophy had lower ERL AUC than those without lipodystrophy (p =0.04). There was no association between ERL AUC and calcifications or fractures.

Conclusion

Persistently decreased ERL capillary density, evident by low ERL AUC, is associated with chronic disease course and lipodystrophy in JDM. Despite medical therapy, the mean ERL count remained below normal even after five years, particularly in polycyclic and chronic cases. Therefore, the goal of restoring normal capillary density in children with JDM might be challenging and require novel therapeutic strategies targeting their underlying endothelial dysfunction.
Changes and driving forces of reservoir landscape pattern vulnerability: A case study of Qianping Reservoir, Luoyang City, Henan Province, China
Authors: Xu Enkai , Li Ying , Lei Yakai , Tian Guohang , Hu Yongge , Li Congshi , Wei Dianwei 
Published: August 2023

Abstract
Based on the land use data of Qianping Reservoir from 2000 to 2020 before and after the construction of Qianping Reservoir, this paper studies the spatial and temporal distribution and change characteristics of landscape pattern and ecological fragility of Qianping Reservoir, and analyzes the driving forces. The results showed (a) the dominant types of landscape were mainly cultivated land and forest land, and the area of construction land and water area increased steadily, while cultivated land showed a decreasing trend. (b) The vulnerability of the study area was mainly in the high vulnerability area and the medium vulnerability area, mainly distributed in the forest land and construction land area, but the overall pattern vulnerability showed a downward trend. Vulnerability is closely related to human activities, has a certain correlation with topography, and is not significantly affected by climate change, but it still reflects some problems. The research results provide a scientific basis for the landscape planning and construction of Qianping Reservoir to promote the sustainable development of the environment, and also provide a reference for the analysis of landscape vulnerability in similar areas.
Integrating CAx with the Chemical Synthesis for Chemical Printer Architecting in Additive Manufacturing with Logic in Materials
Authors: de Lima Edilson Gomes 
Published: August 2023

Abstract
This study proposal presents a hybrid and gradual method for biologic artificialization, engineering its fundamental structure with 3D printing, conferring incremental intelligence on its superficial and deep areas for its control to classify and mimic genetic events over organic or hybrid materials. Thus, functionalized computational blocks to be used as a mechanical computer, driving materials through its most fundamental state material as computing. The route for this research is the mechanical synthesis of material computation architecture drives through quantum control in their fundamental structure using particle computational logic integration to drive molecular structures. This research aims to include the precision techniques of mechanical engineering in the biosciences, i.e., metrology and anthropometry through biometrology, to measure genetic particle components to obtain patterns, through quantum digitization to generate complex mechanical, chemical, and hybrid syntheses in the state-of-the-art for biological circuit process control. It was concluded that cutting-edge CAx intelligence for material sciences can use chemical synthesis artificially for computerizing materials for additive manufacturing.
Targeting HER2/VEGFR2 dual tyrosine kinases with novel Lapatinib and Neratinib hybrid analogues lead to potential apoptotic induction in HER2 positive breast cancers: Design, synthesis, in-vitro, in-vivo and molecular docking studies.
Authors: Varikalla Rajashakar , gangarapu kiran 
Published: August 2023

Abstract
A high percentage of women worldwide will develop breast cancer during their lifetime, and there will always be a need to look for novel breast cancer treatment possibilities. The co-expression of HER2 and VEGFR2 in some breast cancers has been associated with a more aggressive tumour phenotype and poorer prognosis. As part of continuing research focusing on the possibility of simultaneously targeting HER2 and VEGFR2, we describe the design and synthesis of new lapatinib and neratinib hybrid analogues and their in vitro and in vivo evaluation for anti-cancer activity. We used the drug extension strategy to tailor the designed compounds to fit the RTKs, such as EGFR VEGFR2 and HER2 hydrophobic subpocket and cleft regions. The designed lapatinib and neratinib derivatives were successfully synthesized using established synthetic procedures and characterized using 1H, 13C-NMR, HRMS, and elemental analysis. The synthesized compounds were initially tested for their RTK inhibition capabilities, and compounds 15i and 15g were found to possess potential HER2 and VEGFR2 kinase inhibition abilities in-vitro with an IC50 less than the standards lapatinib and sorafenib used. The anti-proliferative capability of all derivatives demonstrated that compounds 15i and 15g potentially suppressed the growth of HER2 positive T-47D and BT-474 cells having a differential expression of HER2 and VEGFR2 with superior activity than lapatinib and sorafenib. SAR revealed that the trifluoromethyl group on the pyridinyl moiety of the side chain at the fourth position of the scaffold made compound 15i the most promising candidate among the other candidates. Flowcytometric apoptotic evaluation of compound 15i demonstrated potential induction of apoptosis at its IC50 in both T-47D and BT-474 cells, which was proved by examining the caspases (Caspase-3, 8, and 9) and Cytochrome-c release. Western blot analysis further determined HER2, VEGFR2, and their downstream signalling partner’s inhibition by the treatment of 15i. Further in-vivo tumour growth reduction by 15i was assessed in the T-47D xenograft mice model stating its potential anti-tumour capability. Based on docking studies, compound 15i was confirmed as a new lead candidate for the dual inhibition of HER2 and VEGFR2.