bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relevance of dedicated multiple sclerosis serum biomarkers in predicting contrast enhancement with gadolinium: Results from the REDUCE‐GAD trial
Authors: Schaefer Jan Hendrik , Schaller‐Paule Martin A. , Wenger Katharina , Mayer Christoph , Mann Ulrike , Bickert Alexander , Steffen Falk , Bittner Stefan , Yalachkov Yavor , Foerch Christian 
Published: May 2023

AbstractBackgroundThe presence of contrast enhancement (CE) on magnetic resonance imaging (MRI) is one of the principal criteria for diagnosis and disease activity of multiple sclerosis (MS). Therefore, MS patients are frequently exposed to contrast agents, which may cause deposition in the brain, restricting its use in repeat examinations. Thus, serum biomarkers may be valuable as surrogate parameters to evaluate MS activity.MethodsREDUCE‐GAD was a prospective, multicentric, biobanking study to determine whether established serum markers (neurofilament light chain [NfL], glial fibrillary acidic protein [GFAP], tau protein, ubiquitin‐carboxyl‐terminal‐hydrolase (UCH‐L1), S100B and matrix‐metalloproteinase 9 [MMP9]) are predictive of CE‐positive MRI lesions. Blood samples were obtained from patients undergoing MRI 5 days before or after collection.ResultsPatients (N = 102) from four different centers with confirmed MS or related disorders were included; n = 57 (55.9%) showed CE on MRI versus n = 45 (44.1%) without CE. Only higher NfL values indicated CE (odds ratio [OR] 1.05; 95% CI 1.0–1.09) and were correlated with number (ρ = 0.47; p < 0.001) and diameter of CE lesions (ρ = 0.58; p < 0.001). Nfl Z‐scores improved diagnostic accuracy (OR 1.52; 95% CI 1.06–2.18). Receiver operator characteristic analysis revealed a reasonable cut‐off value for NfL at 14.1 pg/mL (sensitivity 49.1%; specificity 82.2%; positive predictive value 77.8%; negative predictive value 56.0%). NfL ≥59.2 pg/mL was exclusively observed in patients with CE.ConclusionsEvaluation of several possible serum biomarkers for CE in MS patients provided the most robust results for NfL, particularly as Z‐scores. Following further evaluation, biomarkers may help stratify the application of contrast agents for brain imaging in MS patients.
In situ 15N‐N2O site preference and O2 concentration dynamics disclose the complexity of N2O production processes in agricultural soil
Authors: Wei Huanhuan , Song Xiaotong , Liu Yan , Wang Rui , Zheng Xunhua , Butterbach‐Bahl Klaus , Venterea Rodney T. , Wu Di , Ju Xiaotang 
Published: May 2023

AbstractArable soil continues to be the dominant anthropogenic source of nitrous oxide (N2O) emissions owing to application of nitrogen (N) fertilizers and manures across the world. Using laboratory and in situ studies to elucidate the key factors controlling soil N2O emissions remains challenging due to the potential importance of multiple complex processes. We examined soil surface N2O fluxes in an arable soil, combined with in situ high‐frequency measurements of soil matrix oxygen (O2) and N2O concentrations, in situ 15N labeling, and N2O 15N site preference (SP). The in situ O2 concentration and further microcosm visualized spatiotemporal distribution of O2 both suggested that O2 dynamics were the proximal determining factor to matrix N2O concentration and fluxes due to quick O2 depletion after N fertilization. Further SP analysis and in situ 15N labeling experiment revealed that the main source for N2O emissions was bacterial denitrification during the hot‐wet summer with lower soil O2 concentration, while nitrification or fungal denitrification contributed about 50.0% to total emissions during the cold‐dry winter with higher soil O2 concentration. The robust positive correlation between O2 concentration and SP values underpinned that the O2 dynamics were the key factor to differentiate the composite processes of N2O production in in situ structured soil. Our findings deciphered the complexity of N2O production processes in real field conditions, and suggest that O2 dynamics rather than stimulation of functional gene abundances play a key role in controlling soil N2O production processes in undisturbed structure soils. Our results help to develop targeted N2O mitigation measures and to improve process models for constraining global N2O budget.
Latest potential sowing time of galega (Galega orientalis Lam.) for successful cultivation in the extreme winter conditions of northern Japan
Authors: Nakamura Naoki , Matsumoto Takehiko , Hayashi Taku , Makino Tsukasa 
Published: May 2023

AbstractMixed seeded plots of timothy (Phleum pratense L.) and galega (Galega orientalis Lam.) were established in multiple seeding times from 2014 to 2017 to determine the latest sowing limit in the Konsen region, northern Japan, where growing conditions are severe. Although low yields were observed in some cases when the soil freezing depth was deeper than average, the dry matter yield of the first crop of galega in the year after sowing was higher under conditions that ensured pre‐overwintering plant length growth of 30 cm or more, as compared with growth of less than 30 cm. Galega rhizomes were observed under conditions of pre‐overwintering plant length of 28 cm or more, but not under conditions of less than 28 cm in length. Therefore, achieving 30 cm plant length prior to overwintering is desirable when sowing galega in the Konsen region. Furthermore, the effective cumulative temperature (ECT) required for pre‐overwintering galega to reach 30 cm in plant length was 1079°C, for which seeding dates were calculated to be July 10 and June 29 in terms of calendar days, with 80% and 90% probability. In the Konsen region, galega should be sown earlier than in other regions of Hokkaido to ensure the growth rate because of the effects of soil freezing on overwintering performance.
Lactobacillus plantarum F25‐4 assisted rice soaking reduces the cooking strength of japonica rice for Chinese rice wine brewing
Authors: Yang Liu , Mei Lu , Chen Xin , Sun Hanju , Li Jinglei 
Published: May 2023

SummaryThis study investigated the effect of Lactobacillus plantarum F25‐4 assisted rice soaking (LAS) on the cooking properties of japonica rice used for Chinese rice wine (CRW) production. The effects of LAS and natural soaking were compared based on the chemical composition, thermal characteristics, infrared spectroscopy and sodium dodecyl sulphate‐polyacrylamide gel electrophoresis of rice flour. After LAS, the protein content of the rice was reduced by 17.63%, and the initial temperature (To), peak temperature (Tp) and conclusion temperature (Tc) were reduced by 36.86%, 17.89% and 1.61%, respectively, as revealed by differential scanning calorimetry analysis. The Zeta (ζ) potential value changed from −8.75 mV to −3.99 mV, and the minimum cooking time was reduced by 40% to only 15 min. The viscoelasticity of LAS rice increased after gelatinisation, as confirmed by confocal laser scanning microscope images. The glutelin precursor of the LAS rice disappeared, and the disorder of protein secondary structure increased, but there was no significant difference in the starch crystal area. LAS effectively improved the cooking properties of rice by changing the protein configuration on the surface of starch granules and reducing protein adsorption, leading to increased starch water absorption and decreased rice gelatinisation temperature. Our research suggests that LAS can reduce the cooking temperature of rice in CRW production, thus saving steam consumption during cooking.
Screening and anti‐glioma activity of Chiloscyllium plagiosum anti‐human IL‐13Rα2 single‐domain antibody
Authors: Qin Lanyi , Ren Qingyu , Lu Chaoling , Zhu Tianci , Lu Yijun , Chen Shuangxing , Tong Shuna , Jiang Xiaofeng , Lyu Zhengbing 
Published: May 2023

AbstractGlioblastoma is a common and fatal malignant tumour of the central nervous system, with high invasiveness. Conventional treatments for this disease, including comprehensive treatment of surgical resection combined with chemoradiotherapy, are ineffective, with low survival rate and extremely poor prognosis. Targeted therapy is promising in overcoming the difficulties in brain tumour treatment and IL‐13Rα2 is a widely watched target. The development of new therapies for glioma, however, is challenged by factors, such as the unique location and immune microenvironment of gliomas. The unique advantages of single‐domain antibodies (sdAbs) may provide a novel potential treatment for brain tumours. In this study, Chiloscyllium plagiosum was immunized with recombinant IL‐13Rα2 protein to produce sdAb and sdAb sequences were screened by multi‐omics. The targeted sdAb genes obtained were efficiently expressed in the Escherichia coli prokaryotic expression system, showing a significant binding capacity to IL‐13Rα2 in vitro. The cell proliferation and migration inhibitory effects of recombinant variable domain of the new antigen receptor (VNAR) on glioma cells were detected by CCK‐8 and cell scratch assays. The sdAb obtained in this study showed high in vitro activity and favourable cell proliferation inhibitory effect on glioma cells, with potential clinical application value. The present study also provides a new direction and experimental basis for the development of targeted therapies for glioma.
Recent advances in decision support for beef and dairy farming: modeling approaches and opportunities
Authors: Bang Rasmus Noss , Guajardo Mario , Hansen Bjørn Gunnar 
Published: May 2023

AbstractThis paper surveys recent literature on decision support for beef and dairy farming, covering 110 articles published between 2016 and 2022. We classify these articles based on the type of farm, country of application, objectives and decisions, model scope, and methodology. The paper provides guidance for future research efforts by discussing the choice between whole farm and intrafarm modeling, the choice between optimization and simulation, and how to leverage existing modeling frameworks. Additionally, we identify opportunities for future research and discuss possibilities for increasing the adoption of decision‐support tools in practice by farmers and industry advisors.
NEONATAL AMNIOTIC FLUID ASPIRATION SYNDROME UNDERDIAGNOSED?
Authors: Bousetty S , Patole SK , McBride GA , Whitehall JS 
Published: May 2023

SUMMARYAspiration of uncontaminated amniotic fluid as a cause of significant respiratory distress in neonates is not well documented. We report a term neonate who presented with severe respiratory distress soon after birth. The diagnosis of amniotic fluid aspiration was confirmed at autopsy. Implications of this diagnosis in the management of neonates with respiratory distress are discussed.
Systemic sexism recognition and antisexism encourage gender equality activism: An adaptation of bystander intervention theory
Authors: Chamberlin Kristina G. , Plant E. Ashby 
Published: May 2023

AbstractAlthough great strides have been made toward gender equality in the United States, continued progress is needed. The current paper adapts bystander intervention theory to delineate which individuals are more likely to engage in gender equality activism. We postulated that individuals who identify that systemic sexism causes gender inequalities (i.e., systemic sexism recognition) and who feel personally responsible for advocating against these inequities (i.e., high antisexism) should be most likely to engage in gender equality activism. Cross‐sectional data (Studies 1 and 2) supported that systemic sexism recognition and antisexism were strong predictors of activism intent. Two experiments further demonstrated that exposure to educational paradigms designed to heighten these factors increased systemic sexism recognition (Study 3) and antisexism (Study 4), which were subsequently associated with greater gender equality activism.
Role of non‐coding variants in cardiovascular disease
Authors: Heshmatzad Katayoun , Naderi Niloofar , Maleki Majid , Abbasi Shiva , Ghasemi Serwa , Ashrafi Nooshin , Fazelifar Amir Farjam , Mahdavi Mohammad , Kalayinia Samira 
Published: May 2023

AbstractCardiovascular diseases (CVDs) constitute one of the significant causes of death worldwide. Different pathological states are linked to CVDs, which despite interventions and treatments, still have poor prognoses. The genetic component, as a beneficial tool in the risk stratification of CVD development, plays a role in the pathogenesis of this group of diseases. The emergence of genome‐wide association studies (GWAS) have led to the identification of non‐coding parts associated with cardiovascular traits and disorders. Variants located in functional non‐coding regions, including promoters/enhancers, introns, miRNAs and 5′/3′ UTRs, account for 90% of all identified single‐nucleotide polymorphisms associated with CVDs. Here, for the first time, we conducted a comprehensive review on the reported non‐coding variants for different CVDs, including hypercholesterolemia, cardiomyopathies, congenital heart diseases, thoracic aortic aneurysms/dissections and coronary artery diseases. Additionally, we present the most commonly reported genes involved in each CVD. In total, 1469 non‐coding variants constitute most reports on familial hypercholesterolemia, hypertrophic cardiomyopathy and dilated cardiomyopathy. The application and identification of non‐coding variants are beneficial for the genetic diagnosis and better therapeutic management of CVDs.
Impact of COVID‐19 pandemic on behavioral changes and glycemic control and a survey of telemedicine in patients with diabetes: A multicenter retrospective observational study
Authors: Bouchi Ryotaro , Sugiyama Takehiro , Goto Atsushi , Ohsugi Mitsuru , Yoshioka Narihito , Katagiri Hideki , Mita Tomoya , Hirota Yushi , Ikegami Hiroshi , Matsuhisa Munehide , Araki Eiichi , Yokoyama Hiroki , Minami Masae , Yamazaki Katsuya , Jinnouchi Hideaki , Ikeda Hiroki , Fujii Hitomi , Nogawa Miyuki , Kaneshige Masahiro , Miyo Kengo , Ueki Kohjiro 
Published: May 2023

ABSTRACTAims/IntroductionTo investigate whether the COVID‐19 pandemic affected behavioral changes and glycemic control in patients with diabetes and to conduct a survey of telemedicine during the pandemic.Materials and MethodsIn this retrospective study, a total of 2,348 patients were included from 15 medical facilities. Patients were surveyed about their lifestyle changes and attitudes toward telemedicine. Hemoglobin A1c (HbA1c) levels were compared among before (from June 1 to August 31, 2019) and in the first (from June 1 to August 31, 2020) and in the second (from June 1 to August 31, 2021) year of the pandemic. A survey of physician attitudes toward telemedicine was also conducted.ResultsThe HbA1c levels were comparable between 2019 (7.27 ± 0.97%), 2020 (7.28 ± 0.92%), and 2021 (7.25 ± 0.94%) without statistical difference between each of those 3 years. Prescriptions for diabetes medications increased during the period. The frequency of eating out was drastically reduced (51.7% in 2019; 30.1% in 2020), and physical activity decreased during the pandemic (48.1% in 2019; 41.4% in 2020; 43.3% in 2021). Both patients and physicians cited increased convenience and reduced risk of infection as their expectations for telemedicine, while the lack of physician–patient interaction and the impossibility of consultation and examination were cited as sources of concern.ConclusionsOur data suggest that glycemic control did not deteriorate during the COVID‐19 pandemic with appropriate intensification of diabetes treatment in patients with diabetes who continued to attend specialized diabetes care facilities, and that patients and physicians shared the same expectations and concerns about telemedicine.
The Size Distribution of the Banking Sector and Financial Fragility
Authors: GAO JIAHONG , REED ROBERT R. 
Published: May 2023

AbstractWe study the role of the size distribution of the banking sector for bailout policy and financial fragility in a model of financial intermediation with limited commitment and noisy sunspots. In particular, due to the different costs of mitigating depositors' losses, differences in financial fragility arise endogenously in the sense that the large banking market admits a higher degree of instability. Moreover, the desire to reduce differences in the amount of bailout funding across segments of the banking system leads the fiscal authority to collect less taxes ex‐ante but ends up rendering the scope for run equilibria larger.
Complex geochronological record of an emblematic Variscan eclogite (Haut‐Allier, French Massif Central)
Authors: de Hoÿm de Marien Luc , Pitra Pavel , Poujol Marc , Cogné Nathan , Cagnard Florence , Le Bayon Benjamin 
Published: May 2023

AbstractTwo eclogite samples from the Haut‐Allier record a prograde evolution from ~20 kbar, 650°C to 750°C, 22–23 kbar followed by heating up to 850–875°C and partial melting. Incipient decompression in high‐pressure granulite facies conditions (19.5 kbar, 875°C) was followed by exhumation to high‐temperature amphibolite facies conditions (<9 kbar, 750–850°C). Following a detailed geochemical, petrological, and geochronological investigation using trace‐element data and laser ablation inductively coupled plasma mass spectrometry U–Pb dating of zircon, apatite, and rutile, the eclogites reveal an Ordovician (c. 490 Ma) rifting event followed by Devonian (c. 370–360 Ma) subduction and Carboniferous (c. 350 Ma) exhumation in this part of the French Massif Central. The previously proposed Silurian age for the subduction, which strongly influenced many tectonic models, is definitively rejected. In the light of other geological data from the French Massif Central, including the lithological and geochemical zoning of calc‐alkaline Devonian volcanism, we propose a southward polarity of the subduction and question the very existence of the so‐called Massif Central Ocean. Furthermore, we infer that following subduction, the eclogites were relaminated to the upper plate and exhumed at the rear of the magmatic arc pointing to similarities with the geodynamics of the Bohemian Massif.The petrochronological record of zircon is particularly complex. Metamorphic zircon with clear eclogitic rare‐earth elements patterns (no Eu anomaly and flat heavy rare‐earth elements) and inclusions (garnet, rutile, and omphacite) shows concordant apparent ages that spread from c. 380 down to c. 310 Ma. This apparent age pattern strongly contrasts with the well‐defined age of apatite and rutile of c. 350 Ma. Apparent zircon ages younger than 350 Ma unequivocally testify that zircon can recrystallize outside the conditions of the eclogite facies, which resets the U–Pb while preserving an apparent eclogitic signature. Local fractures filled by analcite, thomsonite, plagioclase, and biotite testify to late interaction of the eclogites with alkaline fluids at relatively low temperatures. This interaction, possibly at c. 310 Ma or later, could lead to the recrystallization of zircon while leaving apatite unaffected.
Ultrasound, photoacoustic, and magnetic resonance imaging to study hyperacute pathophysiology of traumatic and vascular brain injury
Authors: Kamali Ali , Dieckhaus Laurel A. , Peters Emily C. , Preszler Collin A. , Witte Russell S. , Pires Paulo W. , Hutchinson Elizabeth B. , Laksari Kaveh 
Published: May 2023

AbstractBackground and PurposeCerebrovascular dynamics and pathomechanisms that evolve in the minutes and hours following traumatic vascular injury in the brain remain largely unknown. We investigated the pathophysiology evolution in mice within the first 3 hours after closed‐head traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH), two significant traumatic vascular injuries.MethodsWe took a multimodal imaging approach using photoacoustic imaging, color Doppler ultrasound, and MRI to track injury outcomes using a variety of metrics.ResultsBrain oxygenation and velocity‐weighted volume of blood flow (VVF) values significantly decreased from baseline to 15 minutes after both TBI and SAH. TBI resulted in 19.2% and 41.0% ipsilateral oxygenation and VVF reductions 15 minutes postinjury, while SAH resulted in 43.9% and 85.0% ipsilateral oxygenation and VVF reduction (p < .001). We found partial recovery of oxygenation from 15 minutes to 3 hours after injury for TBI but not SAH. Hemorrhage, edema, reduced perfusion, and altered diffusivity were evident from MRI scans acquired 90‐150 minutes after injury in both injury models, although the spatial distribution was mostly focal for TBI and diffuse for SAH.ConclusionsThe results reveal that the cerebral oxygenation deficits immediately following injuries are reversible for TBI and irreversible for SAH. Our findings can inform future studies on mitigating these early responses to improve long‐term recovery.
Research routes on awake bruxism metrics: Implications of the updated bruxism definition and evaluation strategies
Authors: Bracci Alessandro , Lobbezoo Frank , Colonna Anna , Bender Steven , Conti Paulo C. R. , Emodi‐Perlman Alona , Häggman‐Henrikson Birgitta , Klasser Gary D. , Michelotti Ambra , Lavigne Gilles J. , Svensson Peter , Ahlberg Jari , Manfredini Daniele 
Published: May 2023

AbstractBackgroundWith time, due to the poor knowledge on it epidemiology, the need to focus on awake bruxism as a complement of sleep studies emerged.ObjectiveIn line with a similar recent proposal for sleep bruxism (SB), defining clinically oriented research routes to implement knowledge on awake bruxism (AB) metrics is important for an enhanced comprehension of the full bruxism spectrum, that is better assessment and more efficient management.MethodsWe summarised current strategies for AB assessment and proposed a research route for improving its metrics.ResultsMost of the literature focuses on bruxism in general or SB in particular, whilst knowledge on AB is generally fragmental. Assessment can be based on non‐instrumental or instrumental approaches. The former include self‐report (questionnaires, oral history) and clinical examination, whilst the latter include electromyography (EMG) of jaw muscles during wakefulness as well as the technology‐enhanced ecological momentary assesment (EMA). Phenotyping of different AB activities should be the target of a research task force. In the absence of available data on the frequency and intensity of wake‐time bruxism‐type masticatory muscle activity, any speculation about the identification of thresholds and criteria to identify bruxers is premature. Research routes in the field must focus on the improvement of data reliability and validity.ConclusionsProbing deeper into the study of AB metrics is a fundamental step to assist clinicians in preventing and managing the putative consequences at the individual level. The present manuscript proposes some possible research routes to advance current knowledge. At different levels, instrumentally based and subject‐based information must be gathered in a universally accepted standardised approach.
Longitudinal links of parental solicitation, knowledge, and peer approval with deviance during early adolescence
Authors: Liu Dan , Vazsonyi Alexander T. 
Published: May 2023

AbstractThe current study examined growth‐to‐growth associations of parental solicitation, knowledge, and peer approval with deviance during early adolescence, using a 4‐wave, 18‐month self‐reported longitudinal data set from 570 Czech early adolescents (58.4% female; Mage = 12.43 years, SD = 0.66 at baseline). Unconditional growth model tests provided evidence of significant changes in the three parenting behaviors and in deviance over time. Multivariate growth model tests showed that declines in maternal knowledge were associated with increases in deviance, while greater increases in parental peer approval were associated with slower increases in deviance. Findings provide evidence of dynamic changes in parental solicitation, knowledge, and peer approval over time, as well as in deviance; additionally, they importantly show how parental knowledge and peer approval covary developmentally with deviance.