bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated With Low Hiv Testing Rates Among People Aged 15-65 in Maroua 1 Health District, Far North Region
Authors: DJOKO Godfroy rostant POKAM , KETCHAJI Alice , F Juluis Visnel FOYET , TENGOCHE Béatrice , VESSAH Oussena NZIE , N Raoul DJIALA TAWE , TCHIEMOU Gwladys KAMWA , NDOHI Nicole Modeste , KENG Dorcas KAMGUEM , NGONOR Amandine KOE 
Published: June 2023

Abstract
Background:
The HIV/AIDS infection continues to cause enormous damage in the world despite the multiple strategies developed for the response. In view of this, UNAIDS has adopted an acceleration of this response aimed at eliminating it by the year 2030. Indeed, access to screening, which remains underserved in Cameroon, is the first pillar on which action must be taken to achieve this objective. This study aimed to identify factors associated with low HIV testing in Maroua 1 Health District (MHD1).
Methods:
This was an analytical cross-sectional quantitative study and was conducted for the benefit of 808 participants living in the MHD1 using a structured questionnaire. Bivariate logistic regression analyses were established and only significant variables were retained for multivariate analyses. Associations were estimated by calculating the odds ratio, 95% confidence intervals, and P-value.
Results:
Results showed that 383(47.40%) participants had ever been tested and 97(12%) had done so in the past 12 months. Factors associated with low screening were noted as being male(OR=2.79; CI= 1.83–4.31; p-value<0.001), young(OR=7.95; CI=4.02–16.2; p-value<0.001), single (AOR=1.97; CI=1.19 – 3.27; p-value = 0.02), not have been to school (OR=5.25; CI = 2.26 – 12.45; p-value<0.001), low knowledge about HIV (OR= 8.77; CI=4.60 – 17.24; p-value<0.001), have a stigmatizing opinion (OR=2.46; CI=1.36 – 4.38; p-value<0.001), not be related to a partner (OR=1.70; CI=1.04 – 2.79; p-value=0.03), have never been sensitized by health personnel(OR=1.82; CI=1.21–2.75; p-value = 0.001), and have not visited a FOSA in the past 12 months (OR=1.75; CI=1.06–2.75; p-value=0.02).
Conclusion:
The effective consideration of these factors among the interventions of the response in the SD of Maroua 1 will contribute in the achievement of the first target of 95-95-95 objectives and the eradication of HIV by 2030.
O-glycosylation Genes are associated with the immune microenvironment and Predict Prognosis in Esophageal carcinoma
Authors: Cui Junye , Yang Qiuxing , Tai Guomei , Cai Bo , Wang Gaoren 
Published: June 2023

Abstract
Purpose
Esophageal carcinoma (EC) is one of the most common cancers. Esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC) are the common histological types of esophageal cancer, with squamous carcinoma being more prevalent than adenocarcinoma in Asia. Although new treatments for esophageal carcinoma have emerged in recent years, the incidence of EC is increasing. O-linked glycosylation plays an important role in cancer development and immune escape and has been studied in different cancer species, but it has not been studied in esophageal carcinoma. To provide more possibilities for clinical treatment, we find a validated grouping method to predict the prognosis of O-linked glycosylation genes in esophageal carcinoma.
Methods
Clinical profiles of patients with esophageal carcinoma and corresponding RNA data were downloaded from the TCGA database. Estimate, Timer, PCM analyses were used to clarify the immune environment of the cancer and the immune status of identified subgroups. GO, KEGG and GSEA pathway analyses elucidate the underlying mechanisms. Prognostic risk models were constructed using the LASSO algorithm and multivariate COX regression analysis.
Results
In this study, O glycosylation genes in patients with esophageal carcinoma were divided into two groups, and it was found that the C1 group had higher immune scores compared to the C2 group. GO and KEGG enrichment analysis revealed that they were mainly enriched in cAMP signaling pathway and calcium signaling pathway. The risk model based on O glycosylation genes showed its strong predictive power for patients with esophageal carcinoma. Combining the risk model with clinical line graphs can accurately predict the prognosis of patients with esophageal carcinoma.
Conclusion
O glycosylation genes are associated with the immune microenvironment in patients with esophageal carcinoma and can accurately predict the prognosis of patients with esophageal carcinoma.
Associations between Self-Reported Anatomical Characteristics of the Penis, Age and Sexual Dysfunction in Men
Authors: Ventus Daniel , Jern Patrick , Santtila Pekka , Niu Caoyuan 
Published: June 2023

Abstract
Premature ejaculation and erectile dysfunction are common male sexual dysfunctions worldwide, causing substantial distress in men as well as their partners and decrease the quality and stability of romantic relationships. We investigated the associations between self-reported anatomical characteristics of the penis and sexual dysfunctions in an urban sample of Chinese men. We recruited 1085 Chinese urban men aged 18 to 50 (M = 31.37, SD = 5.52) to fill out an online questionnaire regarding anatomical characteristics of the penis as well as early ejaculation and erectile problems via two Chinese online survey platforms. Participants reported their age, height, weight, penile length, penile circumference, circumcision status, and foreskin characteristics as well as answered the International Index of Erectile Function-5 and Checklist for Early Ejaculation Symptoms. Both increasing penile length (M = 14.49, SD = 2.22) and girth (M =15.46, SD = 4.36) were associated with fewer early ejaculation problems, but only increasing penile length was associated with fewer erectile problems. Less foreskin covering the glans penis was associated with fewer early ejaculation and erectile problems. Age was found to have a non-linear relationship with early ejaculation and erectile problems in this cross-sectional study. Specifically, early ejaculation problems increased up to a certain age (31) and then decreased with further increases in age. In conclusion, the relationship between the anatomical characteristics of the penis and sexual function was complex. Also, the results suggest that there is a curvilinear non-monotonic relationship between age and sexual dysfunction.
Factors influencing the usage intention of mHealth apps. A pilot study among the students of healthcare faculties
Authors: Burzyńska Joanna , Jakubus Klaudia , Bartosiewicz Anna , Kruk Wacław 
Published: June 2023

Abstract
Background
Health mobile applications are currently a dynamically developing trend in healthcare. They are used as a diagnostic and therapeutic support, in storing data about the patient's health, in disease prevention, and in health education. The aim of this study was to investigate the technology acceptance and usability of a mobile health applications among selected groups of students of healthcare faculties.
Methods
The research adopted the Unified Theory of Acceptance and Use of Technology (UTAUT2) and extended it by including variables: Perceived Trust and Privacy Concerns. The model was validated, showing good fit of measurement to the collected data of 110 respondents from two universities.
Results
It was found that behavioral intention to use mobile health apps among students is significantly and positively influenced by all UTAUT2 factors, and Performance Expectancy and Habit are the strongest predictors. The weakest predictor were Privacy Concerns. Contrary to previous studies, it was shown that only place of residence of respondents has the significant impact on behavioral intentions related to the use of health mobile application – age, gender, education level, type of school did not play a significant role. The findings have both research and practical implications.
Development of non-covalent triazine framework decorated carbon nanotube as a photocatalyst support for methylene blue dye degradation
Authors: Ratnakumari Setty , Prasanna Dakshinamoorthy , Anuradha Vejendla , Rajeswari T. Raja 
Published: June 2023

Abstract

Non-covalent triazine framework decorated carbon nanotube were prepared by using cyanuric chloride (CC) and biphenyl (BP) and carbon nanotube (CNT) by Friedel-Crafts reaction. The prepared poly(cyanuric chloride-co-biphenyl)-carbon nanotube (Poly(CC-co-BP)-CNT) composite is used as a supporting materials for photocatalyst towards methylene blue (MB) dye degradation. Zinc sulphide (ZnS) and Zinc sulphide-Tin sulphide (ZnS-SnS) nanoparticles were doped on the surface of poly(cyanuric chloride-co-biphenyl)-carbon nanotube (Poly(CC-co-BP)-CNT) composite by using aqueous plant extract of Vanda Testacea as reducing agent. The ZnS/Poly(CC-co-BP)-CNT and ZnS-SnS/Poly(CC-co-BP)-CNT photocatalyst were analyzed using UV-DRS, PL, XRD, EDX and TEM methods. The durability of the prepared photocatalyst were tested using methylene blue dye under different UV light sources and sun light. The photocatalytic activity of ZnS-SnS/Poly(CC-co-BP)-CNT photocatalyst is found to be higher than ZnS/Poly(CC-co-BP)-CNT, unsupported ZnS and ZnS-SnS photocatalyst towards MB dye. This confirms that prepared ZnS-SnS/Poly(CC-co-BP)-CNT photocatalyst is effective for the removal of the methylene blue dye from waste water.
Unregulated Medication Use and Complications: A Case Study of Prolonged Self-Treated Tuberculosis in Nepal
Authors: Achhami Eliz , Lamichhane Seshkant , Mahaju Satyam , Kandel Ashim , Poudel Anubhav , KC Rabina 
Published: June 2023

Abstract
Background: Tuberculosis (TB) is a global public health issue, particularly in resource-constrained countries like Nepal. This case report highlights the consequences of prolonged self-treatment and non-compliance with TB management protocols, emphasizing the need for increased awareness and intervention.
Case Presentation: A 50-year-old male from Nepal self-medicated with anti-tubercular drugs for 13 years after completing the recommended course of treatment. He experienced worsening symptoms, including respiratory distress and visual impairment. Upon evaluation, he was diagnosed with chronic cavitary pulmonary aspergillosis, a complication of prolonged self-medication. The patient received comprehensive treatment, including antifungal therapy, steroids, antibiotics, and respiratory support, resulting in significant improvement.
Conclusions: This case highlights the dangers of self-treatment and non-compliance with TB management protocols. It emphasizes the importance of patient education, awareness programs, and regular follow-up to ensure treatment adherence and detect complications. The case also reveals gaps in the DOTS (Directly Observed Treatment, Short Course) program, including the need for improved surveillance, and a multidisciplinary approach. The complications arising from prolonged self-medication underscore the need for increased awareness, intervention, and patient education in TB management. Improving patient education, raising awareness about the risks of self-medication, and integrating ophthalmologic evaluations into standard management are essential for better TB control in Nepal.
First Appearance of Verticillium tricorpus Causing Verticillium Wilt in tested Okra varieties.
Authors: Farag M. Mohamed , Arafa Ramadan A. A. , Abou-Zeid Mohamed AbdElhalim , Alwutayd Khairiah M. , Moneim Diaa Abd El , Ghebrial Eman W.R. 
Published: June 2023

Abstract
Symptoms of Verticillium wilt were observed on okra (Abelmoschus esculentus L.) grown widely in Beni Suef Governorate (Nasser, Beba and El-Wasta Counties) in summer 2021. All disease symptoms are externally, infected shoots' leaves turn a light green to yellow colour, lose their turgor, and finally desiccate. Individual shoots in a portion of the plant stem may show symptoms, or the symptoms may emerge over the entire plant. In certain cases, the disease typically progresses over months. According to the morphological characteristics of the isolated fungus, disease symptoms and pathogenicity test, Verticillium tricorpus was identified as the causal agent of Verticillium wilt of okra. Identification of this species was confirmed by sequencing of internal transcribed space (ITS region) of ribosomal RNA gene. V. tricorpus absolutely has not previously been reported on okra. The sequencing of this fungus showed close ties with V. tricorpus, as evidenced by the 99.24–100% identity and 97–100% coverage with several strains of V. tricorpus, including the type strain CBS447.54 (NR_126128). The obtained sequences were deposited in the GenBank with accession number MZ936483. Pathogenicity tests confirmed that V. tricorpus was pathogenic showing the same disease symptoms previously observed on okra plants in the surveyed areas. The infection sensitivity showed that Iranian red cv. is more sensitive to infection than Balady green cv. This appears to be the first record of V. tricorpus associated with Verticillium okra wilt disease.
Assessment and identification of potential factors influencing medication literacy in maintenance hemodialysis patients: A cross-sectional study
Authors: Zhu Linfang , Liu Yang , Yang Fengxue , Yu Shaobin , Fu Ping , Yuan Huaihong 
Published: June 2023

Abstract
Background
Maintenance hemodialysis (MHD) patients have complex medication regimens that require a high level of skill to interpret medication information. However, there is currently a lack of research evaluating the ability to read and understand medication labels in Chinese MHD patients. In addition, the relationship between frailty and medication literacy among MHD patients remains unclear. Therefore, this study aims to assess the potential factors affecting medication literacy in MHD patients and to explore the relationship between frailty and medication literacy.
Methods
This cross-sectional study was conducted using convenience sampling in West China Hospital of Sichuan University, China. Using a general questionnaire, we collected demographic, clinical and laboratory data. Medication literacy was assessed by the Chinese Medication Literacy Scale, and frailty was assessed by the FRAIL Scale. Univariate analyses examined potential factors impacting medication literacy. An ordered logistic regression was used to analyze the relationships between medication literacy and these factors. Spearman's correlation was used to assess the association between medication literacy and frailty.
Results
A total of 290 MHD patients were included in the analysis. Inadequate, marginal, and adequate medication literacy was found in 56 (19.3%), 153 (52.8%), and 81 (27.9%) patients, respectively. Ordered logistic regression revealed factors impacting medication literacy: age (OR = 3.561, 95% CI = 1.769–7.171, p < 0.001 for < 65 years); education (OR = 0.116, 95% CI = 0.048–0.284, p < 0.001 for ≤ primary school education; OR = 0.294, 95% CI = 0.145–0.594, p = 0.001 for junior high school education); caregiver medication assistance (OR = 0.434, 95% CI = 0.221–0.852, p = 0.015); frailty (OR = 2.275, 95% CI = 1.120–4.621, p = 0.023 for prefrail patients); and β2-microglobulin (β2-MG) (OR = 0.990, 95% CI = 0.982–0.998, p = 0.012). Spearman's analysis showed that medication literacy was associated with frailty in MHD patients (R=-0.189, p = 0.001).
Conclusions
The Chinese version of the MedLitRxSE tool can help evaluate medication literacy in MHD patients. Medication literacy levels in MHD patients need improvement and differ among patient groups, such as by age, education, caregiver support, β2-microglobulin levels, and risk of frailty.
A retrospective analysis of adverse events reported by Tunisian intensive care professionals
Authors: Tlili Mohamed Ayoub , Aouicha Wiem , Gambashidze Nikoloz , Sahli Jihene , Cheikh Asma Ben , Weigl Matthias , Mtiraoui Ali , Latiri Houyem Said , Chelbi Souad , Mallouli Manel 
Published: June 2023

Abstract
Introduction
Adverse events (AEs) that occur in hospitals remain a challenge worldwide, and especially in intensive care units (ICUs) where they are more likely to occur. Monitoring of AEs can provide insight into the status and advances of patient safety. This study aimed at examining the AEs reported during 20 months after the implementation of AE reporting system.
Methods
We conducted a retrospective analysis of a voluntary ICU AE reporting system. Incidents were reported by staff from 10 ICUs in the Sahloul University Hospital (Tunisia) between February 2020 and September 2021.
Results
A total of 265 reports were received, of which, 61.9% were deemed preventable. The most reported event was healthcare-associated infections (30.2%, n=80), followed by pressure ulcers (18.5%, n=49). At the time of reporting, 25 patients (9.4%) had died as a result of an AE and in 51.3% of cases, the event had resulted in an increased length of stay.
Provider-related factors contributed to 64.2% of the events, whilst patient-related factors contributed to 53.6% of the events. As for criticality, 34.3% of the events (n=91) were unacceptable (c3) and 36.3% of the events (n= 96) were ‘acceptable under control’ (c2).
Conclusions
The reporting system provided rich information on the characteristics of reported AEs that occur in ICUs and their consequences and may be therefore useful for designing effective and evidence-based interventions to reduce the occurrence of AEs.
The effect of PD-1/PD-L1 signaling axis on the interaction between CD19+B cells and CD4+T cells in peripheral blood of patients with systemic Lupus erythematosus
Authors: Xie Zhuobei , Dai Li , He Haohua , Hong Dengxiao , Tang Honghui , Xu Wenyan , Chen Zhongxin , Wang Hongtao , Li Baiqing , Xie Changhao , Wang Yuanyuan 
Published: June 2023

Abstract
Background The defect of B cell self-tolerance and the continuous antigen presentation by T cells (TCs) mediated by autoreactive B cells (BCs) play a key role in the occurrence and development of systemic lupus erythematosus (SLE). PD-1/PD-L1 signaling axis negatively regulates the immune response of TCs after activation and maintains immune tolerance. However, the effect of PD-1/PD-L1 signaling axis on the interaction between CD19+B/CD4+TCs in the peripheral blood of patients with SLE has not been studied in detail.
Methods PD-1/PD-L1 and Ki-67 levels in peripheral blood (PB) of 50 SLE patients and 41 healthy controls (HCs) were detected through flow cytometry, and then the expression of PD-1+/−cells and PD-L1+/−cells Ki-67 was further analyzed. CD19+B/CD4+TCs were separated for cell culture and the supernatant was collected to determine proliferation and differentiation of TCs. IL-10 and IFN-γ secretion in the supernatant was also determined using ELISA.
Results The PD-1, PD-L1, and Ki-67 levels on CD19+B/CD4+TCs in patients with SLE were higher than HCs. In CD19+B/CD4+TCs of SLE patients, the proliferative activity of PD-L1+ cells was higher than that of PD-L1− cells, and the proliferative activity of PD-1+ cells was higher than that of PD-1− cells. In the system co-culturing CD19+B/CD4+TCs from HCs/SLE patients, activated BCs promoted TCs proliferation and PD-L1 expression among TCs. Addition of anti-PD-L1 to co-culture system restored the proliferation of TCs, and inhibited IL-10/IFN-γ level. The addition of anti-PD-L1 to co-culture system also restored Tfh and downregulated Treg in HCs.
Conclusions Axis of PD-1/PD-L1 on CD19+B/CD4+TCs in PB of SLE patients is abnormal, and cell proliferation is abnormal. In CD19+B/CD4+TCs of SLE patients, the proliferative activity of PD-L1+ and PD-1+ cells compared with PD-L1− and PD-1− cells in SLE patients, respectively. CD19+B/CD4+TCs in SLE patients can interact through PD-1/PD-L1.
Development and validation of an in-hospital mortality risk prediction model for patients with severe community-acquired pneumonia in the intensive care unit
Authors: Pan Jingjing , Bu Wei , Guo Tao , Shao Min , Geng Zhi 
Published: June 2023

Abstract
Background
A high mortality rate has always been observed in patients with severe community-acquired pneumonia (SCAP) admitted to the intensive care unit (ICU); however, there are few reported predictive models regarding the prognosis of this group of patients. This study aimed to screen for risk factors and assign a useful nomogram to predict mortality in these patients.
Methods
As a developmental cohort, we used 455 patients with SCAP admitted to ICU. Logistic regression analyses were used to identify independent risk factors for death. A mortality prediction model was built based on statistically significant risk factors. Furthermore, the model was visualized using a nomogram. As a validation cohort, we used 88 patients with SCAP admitted to ICU of another hospital. The performance of the nomogram was evaluated by analysis of the area under the receiver operating characteristic (ROC) curve (AUC), calibration curve analysis, and decision curve analysis (DCA).
Results
Lymphocytes, PaO2/FiO2, shock, and APACHE II score were independent risk factors for in-hospital mortality in the development cohort. External validation results showed a C-index of 0.903 (95% CI 0.838–0.968). The AUC for the development cohort was 0.850 and that for the validation cohort was 0.893. Calibration curves for both cohorts showed agreement between predicted and actual probabilities. The DCA curve results for both cohorts suggested a high clinical application value for the model.
Conclusions
We developed a predictive model based on lymphocytes, PaO2/FiO2, shock, and APACHE II scores to predict in-hospital mortality in patients with SCAP admitted to the ICU. The model has the potential to help physicians assess the prognosis of this group of patients.
Cardiac Metastasis from Cervical Cancer: A Case Report and literature review
Authors: Sun Zhaochen , Chen Yitian 
Published: June 2023

Abstract
Heart metastasis in cervical cancer is an exceptionally uncommon occurrence. Given the early onset of obscure clinical presentations and complex imaging features of cardiac tumors, cases diagnosed before death are exceedingly rare. In this report, we present a case of cervical cancer with cardiac tumor metastasis diagnosed pre-mortem, and conducted a review of the current literature. The following conclusions were drawn: (1) The incidence of cardiac metastasis is influenced by clinical stage and treatment modality at initial diagnosis. (2) The prognosis for patients with cervical cancer heart metastasis is poor, and those with severe complications struggle to accrue benefits from active treatment. (3) When cervical cancer patients present with unexplained dyspnea, cardiac color ultrasound and enhanced chest CT should be performed to rule out tumor cardiac metastasis.