bluuebunny/crossref_metadata_2025_split huggingface dataset:
Connected graph partitioning with aggregated and non‐aggregated gap objective functions
Authors: Fernández Elena , Lari Isabella , Puerto Justo , Ricca Federica , Scozzari Andrea 
Published: August 2023

AbstractThis article deals with the problem of partitioning a graph into connected components by optimizing some balancing objective functions related to the vertex weights. Objective functions based on the gap or range of the partition's components, that is, the difference between the maximum and minimum weight of a vertex in the component, have been already introduced in the literature. Here we introduce the notion of aggregated gap, defined as the sum of the differences between the weights of the vertices and the minimum weight of a vertex in the component. We study new connected ‐partitioning problems whose objective is a function of the components' aggregated gap, and give NP‐hardness results for these problems on general graphs. Mathematical programming formulations are proposed for these problems adopting flow‐based constraints for modeling connectivity in a partition. Even if they are introduced for the new aggregated gap problems, such formulations are rather general and apply also to the classical non‐aggregated gap problems. Extensive computational tests, both for aggregated and non‐aggregated gap problems, are performed on a set of squared grids and randomly generated graphs with up to 120 vertices, and a number of components ranging from 2 to 9. In our experiments, we test several alternative formulations for our problems providing a comparative analysis of their performance.
The coating based on phenolic resin gives rigid polyurethane foam excellent flame retardant properties
Authors: Zhang Wei , Zheng Hui , Zhu Chao‐nan , Xing Feng‐qin , Tong Ming‐yu 
Published: August 2023

AbstractA flame retardant coating was designed and synthesized using phenolic resin (PF), 9,10‐dihydro‐9‐oxa‐10‐phosphazephenanthrene‐10‐oxide (DOPO), and nano‐SiO2 as raw materials. The coating is applied to the surface of rigid polyurethane foam (RPUF) to give it a flame retardant effect. Based on the excellent adhesion of PF, the coating effectively suppresses heat transfer, and the synergistic effect of DOPO and nano‐SiO2 improves the flame retardancy of RPUF. In addition, vertical combustion experiments have shown that when the ratio of DOPO to nano‐SiO2 is 2:1, there is no dripping, the flame is self‐extinguishing, and the internal structure remains basically unchanged, resulting in the best flame retardant effect. The cone calorimetric test shows that the coating can effectively reduce the total heat release and heat release rate of the substrate, and the smoke release rate and total smoke release data show that its smoke suppression effect is significantly improved. Thermogravimetric analysis shows that the coating can effectively improve the residual carbon rate of RPUF, and its mechanical properties are good. This study confirms that coatings based on PF/DOPO/Nano‐SiO2 can effectively improve the flame retardancy of RPUF, providing a potential direction for the development of green insulation materials.
Examining the influence of pain and fatigue on neurocognitive functioning in adolescents and young adults with sickle cell disease
Authors: Semko Joshua H. , Longoria Jennifer , Porter Jerlym , Potter Brian , Bhatia Shalini , Pan Haitao , Hankins Jane S. , Heitzer Andrew M. 
Published: August 2023

AbstractPain and fatigue are among the most common and impactful complications of sickle cell disease (SCD). Individuals with SCD are also more likely to have neurocognitive deficits. Previous studies have suggested that pain and fatigue might influence neurocognitive functioning in patients with SCD. However, these studies are limited by small sample sizes and inadequate measurement of cognitive performance. The present study aimed to investigate the relationship between pain and fatigue with neurocognitive functioning using performance‐based measures of neurocognition. Pain and fatigue were not associated with neurocognitive performance. Implications and directions for future research are discussed.
Long‐term nephrotoxicity in irradiated pediatric kidney tumor survivors: A systematic review
Authors: Dávila Fajardo Raquel , Raymakers‐Janssen Paulien , van Grotel Martine , van Wösten‐van Asperen Roelie M. , Terhaard Christianus H. , Lilien Marc R. , van den Heuvel‐Eibrink Marry M. , Janssens Geert O. 
Published: August 2023

AbstractObjectiveNephrotoxicity can occur as a side effect after treatment for kidney tumor in childhood. The use of radiotherapy (RT) has a potential additional effect.MethodsA systematic electronic literature search that combined childhood kidney cancer with different treatments and nephrotoxicity terms was performed in EMBASE. Studies were included based on the reporting of nephrotoxicity occurrence after treatment for kidney tumor during pediatric age, with 75% of participants being under the age of 25 years at the time of diagnosis, and having been treated with any type of kidney surgery, chemotherapy, and/or RT.ResultsA pooled analysis did not show significant difference in estimated glomerular filtration rate between the group of patients who received RT compared with the group treated without RT (SMD −0.11 [95% CI −1.07–0.84] p = .733).ConclusionThe current literature suggests that the use of RT does not have a significant impact on the decline of kidney function as independent factor.
Intrinsic and extrinsic self‐healing fiber‐reinforced polymer composites: A review
Authors: Wang Juntao , Tang Jun , Chen Dingding , Xing Suli , Liu Xuanyi , Hao Jingye 
Published: August 2023

AbstractWith their high specific modulus, high specific strength and designability, fiber‐reinforced polymer (FRP) composites have replaced or surpassed traditional metallic materials in a wide range of applications. However, the polymer matrix of commonly used FRP composites is usually a thermosetting polymer that is difficult to rework once formed, which implants a substantial challenge for the repair and recycling of composites. Self‐repair, as an emerging method of repairing polymer‐based materials, has the advantages of simplification, high efficiency and repeatability against traditional repair methods. Research on self‐healing polymer materials is developing rapidly and becoming more systematic. With the development of self‐healing polymer, polymer‐based composites with self‐healing capabilities are becoming possible. This paper reviews the current development of self‐healing polymers in recent years, with specific emphasis on their applications in FRP composites. According to the difference in healing mechanisms, the self‐healing polymer composites are split into two categories, intrinsic and extrinsic ones. The essential concepts and different types of intrinsic and extrinsic self‐healing composites are first introduced. Then, their pros and cons are discussed, respectively. Finally, the perspectives of intrinsic as well as extrinsic self‐healing FRP composites are put forward.Highlights
Development of self‐healing fiber‐reinforced polymer composites.
Extrinsic and intrinsic self‐healing fiber‐reinforced polymer composites.
Pros and cons of self‐healing fiber‐reinforced polymer composites.
Perspectives of self‐healing fiber‐reinforced polymer composites.
Void content of polypropylene/carbon fiber wet‐laid nonwoven composites: Effect of fiber content and molding conditions, and void elimination mechanism
Authors: Yan Xin , Zhao Guang‐lei , Yang Jin , Wang Xi‐wen 
Published: August 2023

AbstractVarious wet‐laid nonwoven composites have been well‐developed in recent decades. However, studies that systematically investigate the factors affecting the void content of wet‐laid nonwoven composites are still missing. This paper aims to study the factors affecting the void content of wet‐laid nonwoven composites and propose a mechanism for void elimination in wet‐laid nonwoven composites. Polypropylene (PP) and carbon fiber (CF) were chosen to manufacture PP/CF wet‐laid nonwoven composites. An orthogonal experimental design found that the CF content and molding pressure can dominate the void content while molding temperature and time have non‐significant effects. Subsequently, this paper proposed that the void elimination mechanism is the compression of the impregnated CF network and the trapped air (compression mechanism) instead of the matrix's infiltration to the dry CF network (infiltration mechanism). In order to validate the compression mechanism, we developed an analytical model for predicting the void content of the PP/CF wet‐laid nonwoven composites. Good agreement between the predicted and the experimental void content suggests that void elimination follows the compression mechanism.Highlights
An orthogonal experimental design reveals that the CF content and molding pressure can dominate the void content of the PP/CF wet‐laid nonwoven composite, while molding temperature and time have non‐significant effects.
A mechanism (i.e., compression mechanism) is proposed to explain the effect of CF content and molding conditions on the void content of the PP/CF wet‐laid nonwoven composite.
Good agreement between the experimental and the predicted void content validates the compression mechanism.
A case for screening real‐world data for collateral drug benefits: Glucagon‐like peptide 1 receptor agonists and bile acid diarrhea
Authors: Rahbek Martin Torp , Lund Lars Christian , Hallas Jesper 
Published: August 2023

AbstractPurposeCollateral drug benefits are hitherto unknown beneficial effects that might lead to repurposing of already marketed drugs. A randomized controlled trial has found liraglutide to be non‐inferior to colesevelam in reducing bile acid diarrhea. We hypothesized that this collateral drug benefit of liraglutide could have been detected using observational data.MethodsWe performed a sequence symmetry analysis (SSA). In the SSA, we indexed individuals on the date of the first prescription of GLP1‐RA and restricted the analysis to all individuals who had a first prescription of bile acid sequestrants between 365 days prior to until 365 days after the index date. Sequence ratios (SR), that is, the ratio between counts of persons initiating GLP1‐RA first versus last, were calculated, and 95% confidence intervals were obtained. We adjusted for prescribing trends using null‐effect SR adjustment.ResultsWe included 158 individuals, with a median age of 58 years. The trend‐adjusted SR was 0.96 (95% confidence interval 0.70–1.31). When stratifying on the type of GLP1‐RA (liraglutide or semaglutide), we found results compatible with the previous trial (SRliraglutide 0.75, 0.51–1.10 and SRsemagltuide 1.23, 0.80–1.89). Since BAS also can be used as a cholesterol lowering drug, we repeated the main analysis while excluded statin users, resulting in a stronger association (SR 0.56, 0.33–0.96).ConclusionUsing the SSA methodology, we obtained estimates of a collateral drug benefit that were compatible with trial results. These results support the use of epidemiological analyses of observational data as instrument for detecting collateral drug benefits.
The influence of disparities on intensive care outcomes in children with respiratory diseases: A systematic review
Authors: Hussain Tahira , van den Berg Sarah , Ziesemer Kirsten A. , Markhorst Dick G. , Vijverberg Susanne J. H. , Kapitein Berber 
Published: August 2023

AbstractContextThe negative effects of socioeconomic, environmental and ethnic inequalities on childhood respiratory diseases are known in the development of persistent asthma and can result in adverse outcomes. However, little is known about the effects of these disparities on pediatric intensive care unit (PICU) outcomes in respiratory diseases.ObjectiveThe purpose of this systematic review is to evaluate the literature on disparities in socioeconomic, environmental and ethnic determinants and PICU outcomes. We hypothesize that these disparities negatively influence the outcomes of children's respiratory diseases at the PICU.MethodsA literature search (in PubMed, Embase.com and Web of Science Core Collection) was performed up to September 30, 2022. Two authors extracted the data and independently evaluated the risk of bias with appropriate assessment methods. Articles were included if the patients were below 18 years of age (excluding neonatal intensive care unit admissions), they concerned respiratory diseases and incorporated socioeconomic, ethnic or environmental disparities.ResultsEight thousand seven hundred fourty‐six references were reviewed, and 15 articles were included; seven articles on the effect of socioeconomic status, five articles on ethnicity, one on the effect of sex and lastly two on environmental factors. All articles but one showed an unfavorable outcome at the PICU.ConclusionDisparities in socioeconomic (such as a low‐income household, public health insurance), ethnic and environmental factors (such as exposure to tobacco smoke and diet) have been assessed as risk factors for the severity of children's respiratory diseases and can negatively influence the outcomes of these children admitted and treated at the PICU.
Third generation quinoline‐3‐carboxamide transcriptional disrupter of HDAC4, HIF‐1α, and MEF‐2 signaling for metastatic castration‐resistant prostate cancer
Authors: Isaacs John T. , Dalrymple Susan L. , Antony Lizamma , Marc Rosen David , Coleman Ilsa M. , Nelson Peter S. , Kostova Maya , Murray Iain A. , Perdew Gary H. , Denmeade Samuel R. , Akinboye Emmanuel S. , Brennen W. Nathaniel 
Published: August 2023

AbstractBackgroundThe quinoline‐3‐carboxamide, Tasquinimod (TasQ), is orally active as a maintenance therapy with an on‐target mechanism‐of‐action via allosteric binding to HDAC4. This prevents formation of the HDAC4/NCoR1/HDAC3 complex, disrupting HIF‐1α transcriptional activation and repressing MEF‐2 target genes needed for adaptive survival signaling in the compromised tumor micro environment. In phase 3 clinical testing against metastatic castration‐resistant prostate cancer(mCRPC), TasQ (1 mg/day) increased time‐to‐progression, but not overall survival.MethodsTasQ analogs were chemically synthesized and tested for activity compared to the parental compound. These included HDAC4 enzymatic assays, qRT‐PCR and western blot analyses of gene and protein expression following treatment, in vitro and in vivo efficacy against multiple prostate cancer models including PDXs, pharmacokinetic analyses,AHR binding and agonist assays, SPR analyses of binding to HDAC4 and NCoR1, RNAseq analysis of in vivo tumors, 3D endothelial sprouting assays, and a targeted kinase screen. Genetic knockout or knockdown controls were used when appropriate.ResultsHere, we document that, on this regimen (1 mg/day), TasQ blood levels are 10‐fold lower than the optimal concentration (≥2 μM) needed for anticancer activity, suggesting higher daily doses are needed. Unfortunately, we also demonstrate that TasQ is an arylhydrocarbon receptor (AHR) agonist, which binds with an EC50 of 1 μM to produce unwanted off‐target side effects. Therefore, we screened a library of TasQ analogsto maximize on‐target versus off‐target activity. Using this approach, we identified ESATA‐20, which has ~10‐fold lower AHR agonism and 5‐fold greater potency against prostate cancer patient‐derived xenografts.ConclusionThis increased therapeuticindex nominates ESATA‐20 as a lead candidate forclinical development as an orally active third generation quinoline‐3‐carboxamide analog thatretains its on‐target ability to disrupt HDAC4/HIF‐1α/MEF‐2‐dependent adaptive survival signaling in the compromisedtumor microenvironment found in mCRPC.
Modified analytic hierarchy process for risk assessment of fire and explosion accidents of external floating roof tanks
Authors: Jia Pengyu , Lv Jianyu , Sun Wengang , Jin Hang , Meng Guodong , Li Junfeng 
Published: August 2023

AbstractTo ensure the safe operation of external floating roof (EFR) tanks, it is important to conduct risk assessments for fire and explosion accidents. In this study, we develop a modified analytic hierarchy process to overcome the subjectivity in traditional analytic hierarchy analysis, improved analytic hierarchy process, and fuzzy fault tree analysis. We propose a parameter with a correction factor: the role of the parameter in the model can be gained from further modifying the structural importance of each basic event so as to overcome the subjectivity in traditional analytic hierarchy analysis, improved analytic hierarchy process, and fuzzy fault tree analysis. The judgment matrix for the analytic hierarchy process is constructed based on the modified structural importance of each basic event in a fault tree. The weight factor for each index to the top goal, combined with the fuzzy comprehensive assessment method, is adopted to conduct risk assessments for the fire and explosion accidents of EFR tanks.
N‐benzyl‐2‐methoxy‐5‐propargyloxybenzoamides, a new type of bleaching herbicides targeting the biosynthesis pathway of plastoquinone
Authors: Wei Shaopeng , Zhao Zhuoran , Chen Yu , Li Zhanbin , Huang Yuqian , Zhang Huixia , Ji Zhiqin 
Published: August 2023

AbstractBACKGROUNDPreviously, the herbicidal activity of N‐benzyl‐2‐methoxybenzamides was discovered during a random screening program in our laboratory. The chemicals resulted in bleaching effect of newly grown leaves by interfering with the biosynthesis of β‐carotene in plant.RESULTSA total of 28 benzamides were synthesized and subjected for the evaluation of herbicidal activity. Structure–activity relationship (SAR) showed that introducing propargyloxy group at 5‐position of benzoyl‐benzene ring and fluorine or methyl group at 3‐ or 4‐position of benzyl‐benzene ring is beneficial for the activity. Post‐emergence herbicidal activities of compounds 406 and 412 were comparable to those of mesotrione and diflufenican. Studies on MOA showed that 406 decreased the level of both β‐carotene and plastoquinone (PQ) in treated plants. The bleaching effect in green alga caused by 406 could be reversed by supplying exogenous homogentisic acid (HGA), the precursor of plastoquinone.CONCLUSIONN‐benzyl‐2‐methoxy‐5‐propargyloxybenzoamides were discovered as new candidates for bleaching herbicides. Preliminary investigation on mechanism of action (MOA) showed that the title compounds might indirectly interfere with carotenoid biosynthesis by blocking the production of PQ. © 2023 Society of Chemical Industry.
Stop me if you can: quantification of the effect of interfaces between plots on the dispersal of Cosmopolites sordidus
Authors: Delaplace Alexis , Coulis Mathieu , Chapillon Laure , Cottin Gwenaëlle , Tixier Philippe 
Published: August 2023

AbstractBACKGROUNDCosmopolites sordidus is one of the most damaging pests of banana worldwide. To date, most studies have addressed the control of this pest at the plot level, without considering the landscape scale, whereas between plots dispersion could be important. The aim of this study was to investigate the ability of C. sordidus to cross contrasted field interfaces. The 10 following interfaces were investigated: forests, hedgerows, field tracks, grassy areas, finely and coarsely tilled soil zones, ditches with and without water, vegetable gardening zones, and pheromone trap lines. Individually marked weevils were released on one side of the interface and recovered daily on the other side, allowing the estimation of the velocity and the crossing success of C. sordidus for each interface.RESULTSHighest permeabilities (with a crossing success above 70%) were obtained for vegetable gardening zones, finely tilled soil zones, forests, and coarsely tilled soil zones. Intermediate permeabilities were measured for hedgerows, field tracks, grassy areas, and ditches without water. Only the line of pheromone traps and submerged ditches had a strong barrier effect on C. sordidus, with a crossing success below 12%. Wind strength, percentage of sky, and vegetation height were negatively correlated to the C. sordidus crossing success.CONCLUSIONOverall, our results showed that only ditches with water and lines of pheromone traps were efficient in stopping the dispersal of C. sordidus. The next step will be to conduct research to incorporate the use of these two interfaces at farm and landscape scale into integrated pest management strategies. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Invasion risks presented by Gonopsis affinis and the use of Trissolcus mitsukurii as a biological control agent under present and future climate conditions
Authors: Lian Dan , Wei Jiufeng , Chen Chao , Niu Minmin , Zhang Hufang , Zhao Qing 
Published: August 2023

AbstractBACKGROUNDGonopsis affinis (Uhler) is a stinkbug that represents a significant threat to the production of rice (Oryza sativa L.), sugarcane (Saccharum officinarum L.) and eulalia (Miscanthus sinensis (Andersson)), and has been listed as a sugarcane pest in Japan. Trissolcus mitsukurii Ashmead is an egg parasitoid of G. affinis. To determine the potential of T. mitsukurii to be a biological control agent for G. affinis, we aim to predict the current and future areas of suitable habitat for these two species and their overlap with areas of present crop production. We developed MaxEnt models using two different variable selection methods and compared the two for T. mitsukurii with a CLIMEX model.RESULTSThe results showed extensive suitable areas for G. affinis under current climate conditions in East Asia, West Africa, Madagascar, and South America. These ranges overlap with areas currently being used for the production of the three crops in question. More than half overlap with areas of suitable habitat for T. mitsukurii. The most critical environmental variable determining habitat suitability for G. affinis was showed to be precipitation of warmest quarter, whilst for T. mitsukurii it was minimum temperature of the coldest month.CONCLUSIONBased on our assessment we recommend the immediate implementation of monitoring and invasion prevention measures for G. affinis in southwest China, the Malay Archipelago and West Africa. We suggest that T. mitsukurii be considered for use as a biological control agent in East Asia, Madagascar, Florida and Brazil in the case of future invasions by G. affinis. © 2023 Society of Chemical Industry.