bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Prophylactic Transamine in Reducing Blood Loss during Elective Cesarean Delivery
Authors: Irfan Saima , Yazdani Tehreem , Nisar Salma , Khawar Maliha , Shafqat Hira 
Published: January 2025

Objective: The purpose of the current research was to see how effective Tranexamic Acid is for minimizing loss of blood after elective cesarean section.Study Design: Interventional, randomized, parallel-group study.Place and Duration of Study: Department of Obstetrics and Gynecology, Pak Emirates Military Hospital, Rawalpindi Pakistan, from August 2020 to August 2021.Methodology: Computer-generated random number tables were used to assign 130 females wo were scheduled for cesareansurgery to the Study or Control groups. The research group received TXA and regular treatment, while control group received just routine care. The gravimetric technique was used to determine blood loss in both groups. The percentage difference between hemoglobin levels before and after the operation was determined, the blood loss and percentage drop in hemoglobin were the primary outcome variables. The secondary outcomes of the study include the duration of operation, adverse effects, percentage of patients who lost more than 500ml blood and require for additional uterotonics. The outcome variables were compared using the unpaired t-test and the Chi-square test.Results: Blood loss was significantly lower in the study group from placental delivery until the end of the operation. In the study group, 5(9.3%) of patients had a drop in hemoglobin of more than 10%, whereas 25(39%) of subjects had a drop of more than 10% loss of blood in the process of Lower Segment Caesarean Section.Conclusion: TXA may be administered safely and successfully in Lower Segment Caesarean Section as its use was not linked to any adverse effects.
Joanne Little Acted for Us All
Authors: Greene Christina 
Published: January 2025

Abstract
This chapter explores Black gender politics; and how the Joan Little case unleashed a pointed discussion among African American men and women in the civil rights and Black Power movements about race, rape, and gender. Appearing largely, though not exclusively, in African American publications, key voices included Elaine Brown and Huey Newton from the Black Panther Party, former Student Non-Violent Coordinating Committee (SNCC) member Julian Bond, US Organization leader Maulauna (Ron) Karenga, Martin Luther King Jr.’s successor Ralph Abernathy, and National Alliance Against Racist and Political Repression co-chair Angela Davis. Set against the emergence of Black Power feminism; Black women’s critique of male chauvinism and sexism; and the history of white male sexual abuse of Black women, the discourse avoided the more difficult issue of intra-racial sexual violence.
Epilogue
Authors: Johnson Janiece 
Published: January 2025

Abstract
The enduring themes present as the story of the Mountain Meadows Massacre showed many Americans in the nineteenth century all they needed to know about the Mormons. It was a singular sin that eclipsed everything else. John D. Lee’s trial only began a multitude of expansions on the story of the meadows that flowered in the early 20th century in fictional forays and still endures into the 21st century in books, movies, and television. This troubling episode in American religious history sheds important light on the role of media and popular culture in provoking religious intolerance and continues to resonate in the present.
Introduction
Authors: Lee Wayne E. 
Published: January 2025

Abstract
This chapter introduces key contextual information about how Native Americans in the Eastern Woodlands lived. It uses the analytical frame of “demographic space” to describe how Indians lived in, modified, and claimed a landscape. Most Indian peoples lived in clusters of related villages, each with its own network of fields and paths, and that cluster was surrounded by a much larger zone claimed and used for hunting and/or gathering. The use of that space then set basic hopes and expectations for the outcome of war. This chapter also sets out key definitions of terms, including the “cutting-off way,” strategy, tactics, operations, and why those modern terms can help clarify our understanding of Native American strategic thinking. The chapter outlines the limits to the sources we have, but also explains how those sources can lead to clarity if used with caution.
Fortify, Fight, or Flee
Authors: Lee Wayne E. 
Published: January 2025

Abstract
This chapter explores and compares how two southeastern Native American societies responded to the challenge of defending their home territories against European incursions in the eighteenth century. As the Tuscaroras and the Cherokees learned more about their European opponents, they progressively adapted their defensive techniques. The Tuscaroras relied on increasingly elaborate fortifications, at first successfully, but ultimately leading to a disastrous defeat. The Cherokees, direct observers of the Tuscarora defeat, continued to use fortifications through the middle of the eighteenth century. As the European threat drew closer to their mountain homeland, however, they shifted to a strategy of dispersal, ambush, and attacks on supply trains.
Conclusion
Authors: Shepherd Lauren Lassabe 
Published: January 2025

Abstract
This chapter discusses the emergence of the former students of Young Americans for Freedom, College Republicans, the Intercollegiate Studies Institute, Campus Crusade for Christ, and others of the student Silent Majority into the political sphere under the banner of the New Right (a title they assumed as college students but which was not nationally recognized until after they joined the political world post-graduation). It details their ability to reshape American higher education through the same Astroturf financial backing and mentorship they received as students, especially through their continued campaign of defunding the academy. It includes a discussion of the Scranton Report and the Right’s legacy impediments to educational justice.
Implementación de hilos virtuales para mejorar la velocidad de procesamiento usando JAVA 21
Authors: Berrio Huamani Miguel Angel 
Published: January 2025

La velocidad de respuesta en las aplicaciones es un factor muy importante a considerar, en ese sentido es importante considerar que las aplicaciones actualmente tienen muchos desafíos que considerar para poder obtener una buena velocidad de respuesta con la limitación de recursos con las que contamos. Actualmente una solución que se ha brindado a fin de mejorar esto, es la programación paralela con ello se puede dividir una tarea en diferentes hilos de ejecución. Así también es importante indicar que la implementación de la programación paralela depende mucho de la tecnología usada, en así que Java en su versión 21 nos presenta una nueva interfaz con la creación de hilos virtuales los cuales rompen la limitante de la cantidad de núcleos del procesador con lo cual solo podíamos crear esa cantidad como un máximo de hilos disponibles, con ello se busca que tanto la velocidad, así como el rendimiento de los servicios tengan una mejora considerable.
AMPK-Mediated Multi-Organ Protective Effects of GLP-1 Receptor Agonists
Authors: Wang Xin , Wang Linxi 
Published: January 2025

Review
AMPK-Mediated Multi-Organ Protective Effects of GLP-1 Receptor Agonists

Xin Wang 1 and Linxi Wang 2,*

1 Emergency Department, Fujian Medical University Union Hospital, Fuzhou 350001, China
2 Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou 350001, China
* Correspondence: dr.linxi.wang@foxmail.com

Received: 11 October 2024; Revised: 23 October 2024; Accepted: 20 December 2024; Published: 9 January 2025

Abstract: AMP-activated protein kinase (AMPK) is a key enzyme broadly involved in regulating cellular metabolism, often called an “energy sensor”. Activated AMPK promotes ATP production and storage within cells, primarily by inhibiting ATP-consuming anabolic processes (such as protein, lipid, and ribosomal synthesis) and initiating ATP-producing catabolic pathways (such as fatty acid oxidation and glycolysis) to maintain energy homeostasis. AMPK regulates metabolic processes in various peripheral tissues, including glucose and lipid metabolism, cholesterol metabolism, and fatty acid and protein metabolism in pancreatic β-cells, the cardiovascular system, liver, kidneys, skeletal muscles, and the central nervous system. As an antidiabetic drug, the multi-organ protective effects of Glucagon-like peptide-1 receptor agonists (GLP-1RA) are increasingly being recognized. This paper reviews the mechanisms by which GLP-1RA confers organ protection via the AMPK signaling pathway.
Incidência da Malária na Amazônia Legal: um estudo ecológico descritivo no período de 2012 a 2022
Authors: Borba Amanda Edwards , Aguiar Bruna Nayara Cabral , Almeida Everlândja Gomes de , Aquino Nadia Alves , Martins Fabiana Mânica , Souza Luís Paulo Souza e , Freitas Ronilson Ferreira , Caires Nely Cristina Medeiros 
Published: January 2025

INTRODUÇÃO: A malária é uma doença infecciosa causada pelo parasita do gênero Plasmodium, transmitido para os seres humanos através da picada do mosquito do gênero Anopheles (“mosquito-prego”). Com importância histórica e social dentro do contexto da Amazônia Legal, que possui 99,8% dos casos da doença, a malária nessa área é objeto de estudo deste trabalho. OBJETIVO: Sabendo do impacto da malária na saúde do Brasil e da região Amazônica, o trabalho objetiva analisar o perfil epidemiológico da malária na Amazônia Legal ao longo dos últimos 10 anos de notificação da doença (2012 a 2022), visando obter e organizar dados que sirvam de base para ações preventivas e resolutivas da doença. METODOLOGIA: Trata-se de um estudo descritivo, transversal e observacional, de caráter retrospectivo a respeito do perfil epidemiológico de pacientes positivados para malária na Amazônia Legal no período de 2012 a 2022. Utiliza-se dados secundários disponíveis no DATASUS. As especificações são: número de pessoas diagnosticadas com malária, respectivos sexo e idade, sazonalidade da doença e sua forma clínica. RESULTADOS: Na região, soma-se 448 casos de malária no período estudado, cuja maior concentração se dá no sexo masculino, entre as idades de 20 a 59 anos e nos meses de fevereiro a setembro, com predomínio das infecções por P. vivax. CONCLUSÃO: Por meio dos resultados adquiridos, percebe-se que pelo estudo dos padrões na temática é possível amenizar os impactos da malária no território estudado, a fim de beneficiar cada vez mais as populações suscetíveis.
Orientación socio ocupacional en la educación rural: análisis bibliométrico y sistemático desde el Método Proknow-c
Authors: Avella-Chacón Sandra Milena , Tovar-Gálvez Julio César , Espinosa-Barrera Paula Andrea , Martínez-Pachón Diana 
Published: January 2025

Las brechas en acceso a oportunidades académicas y laborales entre estudiantes del sector rural y urbano en diferentes contextos mundiales son amplias. Según datos, diversas variables como la pobreza, los bajos resultados académicos y la deserción escolar, contribuyen a esta diferencia. Es crucial desarrollar estrategias educativas para los jóvenes rurales que faciliten el acceso a la educación superior y al empleo a partir de alianzas comunitarias. Por lo tanto, esta investigación tiene como objetivo sintetizar el conocimiento actual en Colombia y en el mundo de la Orientación Socio Ocupacional en la Educación Rural, identificando aspectos relevantes y vacíos en la investigación, a través del Proceso de Desarrollo del Conocimiento - Constructivista (ProKnow-C). Se estableció un portafolio de 36 artículos, que permitieron definir cinco aspectos fundamentales de la Orientación Socio Ocupacional en la Educación Rural: la inserción laboral, la transición a la educación superior, el rol del docente rural, el rol de la familia y la orientación educativa enfocada al contexto. Además, el análisis sistemático sugiere que los proyectos pedagógicos productivos, pueden ser una alternativa para la planificación de los proyectos de vida en estudiantes de colegios rurales.
ACCESIBILIDAD, TAMBIÉN EN LA ORIENTACIÓN ACADÉMICA Y PROFESIONAL
Authors: Fernández Soto Olga María , Pérez Albo María José , Fernández Cabanillas Eva María 
Published: January 2025

Cuando se reflexiona sobre la orientación académica y profesional no es habitual detenerse en la accesibilidad, pero no importa únicamente la información que se ofrece, sino que llegue adecuadamente a sus destinatarios. En los dos últimos años, este objetivo ha dirigido las publicaciones Cuaderno de Orientación Académica y Profesional y la Guía para Familias y Alumnos de la Comunidad de Madrid: favorecer que los usuarios puedan acceder, informarse y tomar sus decisiones de manera fundamentada y autónoma.
Para cumplirlo, las publicaciones se evalúan a través de dos vías: por un lado, se analizan los datos procedentes de Google Analytics, que ofrecen información relevante sobre el uso y alcance de la publicación. Por otro lado, se ha realizado una encuesta al profesorado para obtener información sobre el uso que se realiza, la percepción de utilidad de la herramienta y las posibles mejoras. Con los datos obtenidos se han ido implementando modificaciones, añadiendo o resaltando contenidos, introduciendo nuevos filtros y formatos de búsqueda y mejorando la accesibilidad. Como consecuencia, actualmente constituyen un recurso concreto de orientación que contribuye a su vez a la inclusión educativa y social y a la formación permanente del profesorado. Además, se constata el creciente uso de las herramientas digitales en los procesos de orientación. Por último, se destaca la importancia de tener canales de valoración, seguimiento y comunicación sobre estos recursos para ver su repercusión y aceptación y, en última instancia, adaptar las modificaciones al destinatario final.
Effectiveness of Educational Intervention Regarding Polycystic Ovarian Syndrome Among Undergraduate Students of Tanahu
Authors: Shrestha Remana , Darshandhari Gayetri 
Published: January 2025

Background: PCOS is a complex endocrine disorder characterized by hormonal imbalances, reproductive irregularities, and metabolic disturbances. The overall objective was to find out effectiveness of the educational intervention on knowledge on polycystic ovarian syndrome among undergraduate students.
Methods: This true experimental study design was carried out in a selected campus of Tanahun district. The study population was undergraduate students who were 18 years and above. A systematic random sampling technique was adopted to select the sample. Data was collected by a pre-tested self-administered questionnaire before educational intervention. The questionnaire was developed by the researcher herself/himself through consulting subject experts and searching literature. The educational intervention package was developed. After three weeks of intervention, a posttest was conducted. The data was entered on SPSS 21.0 version and the result was analyzed by using descriptive statistics and inferential statistics.
Results: The knowledge levels of respondents before and after the intervention, along with a control group show that in the pre-intervention phase, a substantial majority of students (96.6%) had an unsatisfactory knowledge level, while only 3.4% fell into the satisfactory category. Following the intervention, with 100% of students achieving a satisfactory knowledge level. In the control group there is a maintained high percentage of unsatisfactory knowledge pre-intervention (98.3%), with a marginal decrease to 96.6% post-intervention. In a study the intervention group showed a significant increase in knowledge with a median pretest score of 3 rising to 28 posttest. Their change score of 25 was highly significant (p=0.00). The control group had a smaller increase from a pretest score of 0 to 2 posttest, with a change score of 2 and a significant p value indicating the intervention’s effectiveness.
Conclusion: The positive outcomes observed in this study underscore the importance of an educational initiative in the broader context of health education for young adults.
Efficacy of Open Reduction and Internal Fixation Assisted by Handheld Ultrasound Combined with 3D Printing Technology in Treating Multiple Rib Fractures
Authors: Li Jieshi , Chen Qianshun , Xu Xunyu , Zhuo Yimeng , Zhang Minhui , Zhou Dong , Li Zhong 
Published: January 2025

AIM: This study aimed to explore the efficacy of open reduction and internal fixation assisted by handheld ultrasound combined with three-dimensional (3D) printing technology in treating multiple rib fractures.
METHODS: We retrospectively analyzed the clinical data from 84 patients affected with multiple rib fractures admitted to our hospital between August 2022 and April 2024. After excluding four cases, 80 cases were included in this study. Based on the method of preoperative rib fracture localization, patients were divided into three groups: group A (n = 30), group B (n = 26), and group C (n = 24). Group A received 3D reconstruction of ribs on chest Computed Tomography (CT), group B adopted the examination of handheld ultrasound and 3D reconstruction of ribs on chest CT, and group C received handheld ultrasound, 3D reconstruction of ribs on chest CT, and 3D printing technology. The operation-related indicators (such as incision length, exposure time of surgical field, intraoperative blood loss), pulmonary function [total lung capacity (TLC), forced vital capacity (FVC), forced expiratory volume in one second/forced vital capacity (FEV1/FVC), residual volume (RV)], quality of life, degree of pain, and incidence of complications were compared among the three groups.
RESULTS: Before surgery, there were no significant differences in pulmonary function, quality of life, and degree of pain among the three groups (p > 0.05). However, after surgery, significant differences in the pairwise comparison of TLC, FVC, FEV1/FVC and RV were observed among the three groups (p < 0.001), with group C indicating the highest levels of observational indicators and group A exhibiting the lowest levels. Furthermore, a significant difference was observed in the pairwise comparison of incision length, exposure time of surgical field, and intraoperative blood loss among the three groups (p < 0.001). Group C had the shortest incision length, the lowest exposure time in the surgical field, and the least intraoperative blood loss, while those in group A were the opposite. After surgery, a significant difference was found in the pairwise comparison of the quality of life and degree of pain among the three groups (p < 0.001). Group C had the highest quality of life and the lowest degree of pain, while Group A had the opposite results. Additionally, there was no significant difference in the incidence of complications among the three groups (p > 0.05).
CONCLUSIONS: The open reduction and internal fixation assisted by handheld ultrasound combined with 3D printing technology revealed effective curative outcomes in treating multiple rib fractures. This method promotes the formulation of an accurate and personalized surgical plan and seems to have high clinical significance.
Effect of Fast-Track Surgery Based on Nutritional Support in the Rehabilitation of Patients Undergoing Radical Thyroidectomy and Lateral Lymphadenectomy: A Retrospective Analysis
Authors: Chen Cheng , Dong Xuemei , Zhang Shoupeng , Wu Jun , Zhu Junling 
Published: January 2025

AIM: This study aims to investigate the impact of fast-track surgery (FTS), based on nutritional support, on postoperative rehabilitation and nutritional status in patients undergoing radical thyroidectomy and lateral lymphadenectomy.
METHODS: This retrospective study included 112 patients who underwent radical thyroid cancer surgery and lateral neck lymph node dissection at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, between April 2021 and April 2023. Based on various nursing methods, patients were divided into two groups, with 58 patients included in the observation group (FTS care based on nutritional support), and 54 patients in the control group (routine perioperative care). Postoperative clinical indicators, nutritional status, Quality of Life, associated complications, and follow-up outcomes at 3 and 12 months were compared between the two groups.
RESULTS: Patients in the observation group showed significantly shorter meal times, hospital stays, and off-bed time compared to the control group (p < 0.05). After three months of intervention, the observation group had higher body weight, muscle mass, and body fat, and lower Nutritional Risk Screening (NRS) scores compared to the control group (p < 0.05). At the 12-month follow-up, the observation group had better nutritional status indicators than the control group (p < 0.05). Furthermore, the observation group exhibited higher Quality of Life scores (p < 0.001) and reduced incidence of delayed complications (p < 0.05). During the three-month follow-up, the observation group demonstrated higher Quality of Life Questionnaire Core 30 (QLQ-C30) score compared to the control group (p < 0.05). Additionally, the overall incidence of complications was significantly lower in the observation group (p < 0.05).
CONCLUSIONS: FTS nursing based on nutritional support effectively promotes postoperative recovery, improves nutritional status, and enhances Quality of Life in patients following radical thyroidectomy and lateral lymphadenectomy, which is worthy of being widely popularized.
Impact of Pterygium Excision Combined with Autologous Limbal Stem Cell Transplantation on Microvascular Density, Tear Film Stability, and Corneal Wound Healing
Authors: He Mengxuan , Li Na , Li Jingjing , Huang Xiaobo 
Published: January 2025

AIM: This study aimed to evaluate the impact of pterygium excision combined with autologous limbal stem cell transplantation on microvascular density, tear film stability, and corneal wound healing in the management of pterygium.
METHODS: A retrospective analysis was conducted on 317 patients with pterygium who underwent treatment between January 2021 and January 2024. Patients were divided into a control group (pterygium excision alone, n = 161) and a study group (pterygium excision combined with autologous limbal stem cell transplantation, n = 156) based on the surgical approach. The study compared the surgical efficacy, perioperative outcomes, and corneal healing between the two groups. Preoperative and postoperative changes in conjunctival microvascular density, tear film stability indicators, and ocular comfort scores were also assessed.
RESULTS: The effective treatment rate was significantly higher in the study group compared to the control group (p < 0.05). Postoperative uncorrected visual acuity, vertical corneal curvature, and horizontal corneal curvature were significantly better in the study group, whereas corneal astigmatism was lower than in the control group (p < 0.05). The postoperative levels of pigment epithelial derived factor (PEDF) were higher in the study group, while levels of vascular endothelial growth factor (VEGF) and microvascular density (MVD) were lower than in the control group (p < 0.05). Corneal healing scores on postoperative days 1, 3, and 7 were lower in the study group than in the control group, and the time resolution of corneal wound congestion and corneal epithelial coverage was significantly shorter compared to the control group (p < 0.05). Tear film stability, as indicated by the Schirmer I test (SIt) and tear breakup time (BUT), was improved in the study group than that in the control group (p < 0.05). Postoperative ocular comfort scores were lower in the study group compared to the control group (p < 0.05). No significant difference in postoperative complication rates was observed between the groups (p > 0.05).
CONCLUSIONS: Pterygium excision combined with autologous limbal stem cell transplantation effectively inhibits angiogenesis, improves visual function, enhances tear film stability, and accelerates corneal wound healing, making it a superior treatment option for pterygium.