bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrologic–hydraulic assessment of SUDS control capacity using different modeling approaches: a case study in Bogotá, Colombia
Authors: Ortega Sandoval Abby Daniela , Sörensen Johanna , Rodríguez Juan Pablo , Bharati Luna 
Published: June 2023

Abstract
Urban flooding has increased in response to impervious surface intensification, the loss of green areas, and high-intensity rainfall associated with climate change. Sustainable urban drainage systems (SUDS) are an appealing option for stormwater management; however, their hydraulic control capabilities have received little attention. We developed a comparative model-based approach with 24 scenarios to contrast the hydrologic and hydraulic response of a highly discretized (HD) 1D model and a coupled 1D–2D model, considering the impact of rainwater harvesting systems and tree pits. An additional scenario was modeled including attenuation storage tanks, green roofs, and pervious pavements. A heavily urbanized flood-prone catchment with severe land-use constraints in Bogotá, Colombia, was selected for analysis. The findings revealed that SUDS can contribute to reducing the number of flooded junctions, overloaded conduits' length, overloading time, nodal inundation depth, and waterlogging extent. Furthermore, the HD 1D model can reproduce the coupled 1D–2D model results in terms of hydrologic response and some hydraulic control indicators. Further research is needed for an accurate description of the internal hydraulic mechanisms of SUDS interacting with overland flow. The key findings of this study provide model-based evidence to support urban stormwater management decision-making in data-scarce environments.
An Updated Review on the Significance of DNA and Protein
Methyltransferases and De-methylases in Human Diseases: From
Molecular Mechanism to Novel Therapeutic Approaches
Authors: Ghanbari Mohammad , Khosroshahi Negin Sadi , Alamdar Maryam , Abdi Adel , Aghazadeh Aida , Feizi Mohammad Ali Hosseinpour , Haghi Mehdi 
Published: June 2023

Abstract:
Epigenetic mechanisms are crucial in regulating gene expression. These mechanisms
include DNA methylation and histone modifications, like methylation, acetylation,
and phosphorylation. DNA methylation is associated with gene expression suppression;
however, histone methylation can stimulate or repress gene expression depending on the
methylation pattern of lysine or arginine residues on histones. These modifications are key
factors in mediating the environmental effect on gene expression regulation. Therefore,
their aberrant activity is associated with the development of various diseases. The current
study aimed to review the significance of DNA and histone methyltransferases and demethylases
in developing various conditions, like cardiovascular diseases, myopathies, diabetes,
obesity, osteoporosis, cancer, aging, and central nervous system conditions. A better
understanding of the epigenetic roles in developing diseases can pave the way for developing
novel therapeutic approaches for affected patients.
Deferoxamine Interference in Fibro-inflammation: Additional Action in
Control of Obese Adipose Tissue Dysfunction
Authors: Ferreira Gotardo Erica Martins , de Morais Thaina Rodrigues , Timóteo Ferreira Ana Paula , Rabelo e Paiva Caria Cintia , Ribeiro Marcelo Lima , Gambero Alessandra 
Published: June 2023

Introduction:
Several studies demonstrated that deferoxamine, an iron chelator, can improve
inflammatory alterations in adipose tissue induced by obesity. Obesity alterations in adipose
tissue are also associated with tissue remodeling, and deferoxamine has anti-fibrosis action previously
described in sites like the skin and liver.

Methods:
In this work, we analyzed deferoxamine effects on adipose tissue fibro-inflammation during
obesity induced by diet in mice. in vitro approaches with fibroblasts and macrophages were also
carried out to elucidate deferoxamine activity.

Results:
Our results demonstrated that in addition to exerting anti-inflammatory effects, reducing
the cytokine production in adipose tissue of obese mice and by human monocyte differentiated in
macrophage in vitro, deferoxamine can alter metalloproteinases expression and extracellular matrix
production in vivo and in vitro.

Conclusion:
Deferoxamine could be an alternative to control fibro-inflammation in obese adipose
tissue, contributing to the metabolic improvements previously described.
Stepping Up the Personalized Approach in COPD with Machine Learning
Authors: Mekov Evgeni , Miravitlles Marc , Topalovic Marko , Singanayagam Aran , Petkov Rosen 
Published: June 2023

Introduction:
There is increasing interest in the application of artificial intelligence (AI) and machine learning (ML) in all fields of medicine to facilitate greater personalisation of management.

Methods:
ML could be the next step of personalized medicine in chronic obstructive pulmonary disease (COPD) by giving the exact risk (risk for exacerbation, death, etc.) of every patient (based on his/her parameters like lung function, clinical data, demographics, previous exacerbations, etc.), thus providing a prognosis/risk for the specific patient based on individual characteristics (individu-al approach).

Result:
ML algorithm might utilise some traditional risk factors along with some others that may be location-specific (e.g. the risk of exacerbation thatmay be related to ambient pollution but that could vary massively between different countries, or between different regions of a particular country).

Conclusion:
This is a step forward from the commonly used assignment of patients to a specific group for which prognosis/risk data are available (group approach).
Biological Potential and Therapeutic Effectiveness of Hinokiflavone in
Medicine: The Effective Components of Herbal Medicines for Treatment
of Cancers and Associated Complications
Authors: Patel Dinesh Kumar 
Published: June 2023

Background:
Plants have been providing us medicines and food material for centuries.
Traditional system of medicine, including Ayurveda, and Traditional Chinese medicines have been
playing important role in health sectors for the treatment of human disorders since very early age.
Plant secondary metabolites, including flavonoids, coumarins, saponins, and tannins have significant
therapeutic potential in medicine. Biflavonoids are dimers of flavonoids, linked by a C–O–C or
C–C bond. Hinokiflavone is an important class of biflavonoids found to be present in Toxicodendron
succedaneum, Isophysis tasmanica, Juniperus rigida, Juniperus phoenicea, Platycladi
cacumen, Rhus succedanea, Selaginella tamariscina, Platycladus orientalis, Selaginella bryopteris,
and Metasequoia glyptostroboides.

Methods:
Biological potential of hinokiflavone in medicine have been analyzed in the present work
through scientific data analysis of various literature work. Scientific database, including Google,
Scopus, Science Direct, and PubMed were searched to collect all the scientific information of the
present work using terms flavonoid, biflavonoid, herbal medicine, and hinokiflavone. Pharmacological
activities of hinokiflavone were analyzed in the present work in very detailed manner. Analytical
data of hinokiflavone were collected and analyzed in present work in order to know the biological
source of hinokiflavone.

Results:
Present work signified the biological importance of hinokiflavone against various types of
cancerous disorders, including breast cancer, colorectal cancer, esophageal squamous cancer, adenocarcinoma,
hepatocellular carcinoma, myeloid leukemia, and melanoma. Further, its antiinflammatory,
hepatoprotective, anti-viral, and anti-oxidant potential were also discussed in the
present work. Moreover, its biological potential against COVID-19 and hair loss, and procoagulant
activity were also summarized in this paper. Analytical data on hinokiflavone signified the importance
of various analytical techniques in the extraction, separation, and identification of hinokiflavone
with their pharmacokinetic parameters.

Conclusion:
Present work signified the biological importance and therapeutic potential of hinokiflavone
in medicine.
Democratizing the Development of Chatbots to Improve Public Health: Feasibility Study of COVID-19 Misinformation
Authors: Powell Leigh , Nour Radwa , Sleibi Randa , Al Suwaidi Hanan , Zary Nabil 
Published: June 2023

Background
Chatbots enable users to have humanlike conversations on various topics and can vary widely in complexity and functionality. An area of research priority in chatbots is democratizing chatbots to all, removing barriers to entry, such as financial ones, to help make chatbots a possibility for the wider global population to improve access to information, help reduce the digital divide between nations, and improve areas of public good (eg, health communication). Chatbots in this space may help create the potential for improved health outcomes, potentially alleviating some of the burdens on health care providers and systems to be the sole voices of outreach to public health.

Objective
This study explored the feasibility of developing a chatbot using approaches that are accessible in low- and middle-resource settings, such as using technology that is low cost, can be developed by nonprogrammers, and can be deployed over social media platforms to reach the broadest-possible audience without the need for a specialized technical team.

Methods
This study is presented in 2 parts. First, we detailed the design and development of a chatbot, VWise, including the resources used and development considerations for the conversational model. Next, we conducted a case study of 33 participants who engaged in a pilot with our chatbot. We explored the following 3 research questions: (1) Is it feasible to develop and implement a chatbot addressing a public health issue with only minimal resources? (2) What is the participants’ experience with using the chatbot? (3) What kinds of measures of engagement are observed from using the chatbot?

Results
A high level of engagement with the chatbot was demonstrated by the large number of participants who stayed with the conversation to its natural end (n=17, 52%), requested to see the free online resource, selected to view all information about a given concern, and returned to have a dialogue about a second concern (n=12, 36%).

Conclusions
This study explored the feasibility of and the design and development considerations for a chatbot, VWise. Our early findings from this initial pilot suggest that developing a functioning and low-cost chatbot is feasible, even in low-resource environments. Our results show that low-resource environments can enter the health communication chatbot space using readily available human and technical resources. However, despite these early indicators, many limitations exist in this study and further work with a larger sample size and greater diversity of participants is needed. This study represents early work on a chatbot in its virtual infancy. We hope this study will help provide those who feel chatbot access may be out of reach with a useful guide to enter this space, enabling more democratized access to chatbots for all.
The Association Between Goal Setting and Weight Loss: Prospective Analysis of a Community Weight Loss Program
Authors: Wren Gina M , Koutoukidis Dimitrios A , Scragg Jadine , Whitman Michael , Jebb Susan 
Published: June 2023

Background
Goal setting aids health-related behavior changes; however, the influence of different types of goals on weight loss remains unclear.

Objective
We aimed to investigate the association of 3 aspects of goal setting with weight and program dropout over a 24-week period.

Methods
This study was a prospective longitudinal analysis of participants in a 12-week digital behavioral weight loss program. Weight and engagement data for eligible participants (N=36,794) were extracted from the database. Eligible participants were adults in the United Kingdom who had enrolled in the program, had a BMI ≥25 kg/m2, and a weight reading recorded at baseline. Three aspects of goal setting were self-reported at enrollment: weight loss motivation (appearance, health, fitness, or self-efficacy), overall goal preference (low, medium, or high), and percentage weight loss goal (<5%, 5%-10%, or >10%). Weight was measured at 4, 12, and 24 weeks. Mixed models for repeated measures were used to explore the association between goals and weight across the 24-week period. To measure sustained weight change, the primary outcome was weight at 24 weeks. We explored dropout rates over the 24-week period by goal and whether engagement mediated the association between goals and weight loss.

Results
Of the 36,794 participants (mean 46.7, SD 11.1 years; 33,902/36,794, 92.14% female) included in the cohort, 13.09% (n=4818) reported weight at 24 weeks. Most participants set goals of 5%-10% weight loss (23,629/36,794, 64.22%), but setting goals for >10% was associated with greater weight loss (mean difference 5.21 kg, 95% CI 5.01-5.41; P<.001). There was no difference between goals of 5%-10% and <5% (mean difference 0.59 kg, 95% CI 0.00-1.18; P=.05). Appearance was the most prevalent motivational factor (14,736/36,794, 40.05%), but health and fitness were associated with greater weight losses (mean difference health vs appearance 1.40 kg, 95% CI 1.15-1.65; P<.001 and mean difference fitness vs appearance 0.38 kg, 95% CI 0.05-0.70; P=.03). Goal preference had no association with weight. Engagement was an independent predictor of weight loss but not a mediator of the effect of goal setting. At 24 weeks, those who set goals of >10% were less likely to drop out compared with 5%-10% goals (odds ratio [OR] 0.40, 95% CI 0.38-0.42; P<.001); those who liked to set overall high goals were more likely to drop out compared with medium goals (OR 1.20, 95% CI 1.11-1.29; P<.001); and those motivated by fitness or health were less likely to drop out compared with appearance (OR 0.92, 95% CI 0.85-0.995; P=.04 and OR 0.84, 95% CI 0.78-0.89; P<.001, respectively).

Conclusions
Setting higher weight loss goals and being motivated by health or fitness were associated with greater weight loss and lower likelihood of dropout. Randomized trials for setting these types of goals are required to confirm causality.
Quality and Reliability of Liver Cancer–Related Short Chinese Videos on TikTok and Bilibili: Cross-Sectional Content Analysis Study
Authors: Zheng Shusen , Tong Xinyu , Wan Dalong , Hu Chen , Hu Qing , Ke Qinghong 
Published: June 2023

Background
Liver cancer incidence has been increasing in China in the recent years, leading to increased public concern regarding the burden of this disease. Short videos on liver cancer are disseminated through TikTok and Bilibili apps, which have gained popularity in recent years as an easily accessible source of health information. However, the credibility, quality, and usefulness of the information in these short videos and the professional knowledge of the individuals uploading health information–based videos in these platforms have not yet been evaluated.

Objective
Our study aims to assess the quality of the information in Chinese short videos on liver cancer shared on the TikTok and Bilibili short video–sharing platforms.

Methods
In March 2023, we assessed the top 100 Chinese short videos on liver cancer in TikTok and Bilibili (200 videos in total) for their information quality and reliability by using 2 rating tools, namely, global quality score (GQS) and the DISCERN instrument. Correlation and Poisson regression analyses were applied to discuss the factors that could impact video quality.

Results
Compared to Bilibili, TikTok is more popular, although the length of the videos on TikTok is shorter than that of the videos on Bilibili (P<.001). The quality of the short videos on liver cancer in TikTok and Bilibili was not satisfactory, with median GQS of 3 (IQR 2-4) and 2 (IQR 1-5) and median DISCERN scores of 5 (IQR 4-6) and 4 (IQR 2-7), respectively. In general, the quality of videos sourced from professional institutions and individuals was better than that of those sourced from nonprofessionals, and videos involving disease-related knowledge were of better quality than those covering news and reports. No significant differences were found in the quality of videos uploaded by individuals from different professions, with the exception of those uploaded by traditional Chinese medicine professionals, which demonstrated poorer quality. Only video shares were positively correlated with the GQS (r=0.17, P=.01), and no video variables could predict the video quality.

Conclusions
Our study shows that the quality of short videos on health information related to liver cancer is poor on Bilibili and TikTok, but videos uploaded by health care professionals can be considered reliable in terms of comprehensiveness and content quality. Thus, short videos providing medical information on TikTok and Bilibili must be carefully considered for scientific soundness by active information seekers before they make decisions on their health care management.
Organoleptic Test of Kombucha Made from Various Tea Sources and Fermentation Time
Authors: Khaerah Azrini , Ardianto  
Published: June 2023

Background: This research aims to find the best mixture of kombucha that can accept by the community in BTN Pa’jukukang, Bantaeng district. Kombucha is a fermented beverage made from tea and sugar mixed with the kombucha culture. A kombucha culture is a mixture of bacteria and yeast designated as SCOBY in this work. Methods: In this research, kombucha was made from 4 various teas, i.e., black tea, green tea, oolong tea, and white tea. Each tea was fermented for 7 and 14 days. The kombucha tea samples were subjected to an organoleptic test based on the consumer's acceptance level. The organoleptic test data were analyzed using the hedonic and score test. Results: The test result showed that respondents preferred to choose the color, the smell, and the taste of the black kombucha tea which was fermented for 7 days. Conclusions: Furthermore, the observation of the physical characteristics of the tea showed that the longer the fermentation time, the more acidic the kombucha. This acidic kombucha resulted from the decreasing sugar level during the fermentation process due to the activity of bacteria and khamir in the SCOBY.
niños del caliche
Authors: Valenzuela Vásquez Carolina 
Published: June 2023

El presente artículo se adentra en la condición de la infancia en la Pampa Salitrera del distrito minero de Taltal 1900-1920, en su vinculación con el sistema de educación formal y el mundo del trabajo, en un contexto, por un lado, de expansión del salitre y de modernización, y por otro, de escasa legislación laboral y no obligatoriedad de la instrucción primaria, que va configurando una experiencia de la niñez pampina alejada de los parámetros modernos de ésta, con una acentuada normalización del trabajo infantil y poca valorización del espacio de la escuela, como configuración de la identidad de éstos.
The Climate Sensitivity of Mosquito Habitats: Simulating Subseasonal Climate Impacts on Dengue Vector Breeding Sites
Authors: Yasanayake Chanud N , Zaitchik Benjamin F 
Published: June 2023

Climate modulates the incidence of mosquito-borne diseases, in part due
to climatic impacts on the suitability of vector breeding habitats.
While the existence of a mechanistic link between climate and habitat
suitability is clear—the aquatic early life stages of mosquitoes are
impacted by climate-driven variability in water level and
temperature—what is less well-defined is the sensitivity of
these habitats to climate variability, which can be dependent on myriad
factors such as the physical properties of the habitats as well as the
timescale of interest.
In this work we focus on the habitats of Aedes aegypti and
Aedes albopictus, the urban-adapted vectors of dengue that
primarily breed in artificial containers (e.g., water tanks, flower
pots, discarded tires). We investigate the climate sensitivity of these
habitats using the energy balance container model WHATCH’EM (NCAR).
WHATCH’EM simulates the (hourly) temporal evolution of water height and
temperature within a container habitat based on user-specified
parameters (e.g., container dimensions, shading, thermal conductivity)
and climate inputs (e.g., timeseries of air temperature, relative
humidity, rainfall).
Here we discuss our implementation of this model, using WHATCH’EM to (a)
understand model sensitivity within a parameter space informed by
existing entomological surveillance data for Sri Lanka, and (b) test
habitat sensitivity to climate variability due to the Madden–Julian
Oscillation (MJO), the quasiperiodic atmospheric disturbance that
primarily drives subseasonal variability in the tropics. By doing so we
will assess the extent to which the habitats of dengue vectors show
MJO-associated subseasonal climate sensitivities.
Methodological potential of the concrete poetry for development of written speech in foreign language teaching
Authors: Макарова Юлия Александровна 
Published: June 2023

Рассматривается возможность использования методического потенциала текстов конкретной поэзии в процессе обучения иноязычной письменной речи в вузе. Эксперимент по применению текстов конкретной поэзии в обучении письму на немецком языке состоял из репродуктивно-продуктивного и продуктивного этапов. В эксперименте приняли участие студенты третьего и четвертого курсов факультета гуманитарного образования Новосибирского государственного технического университета, обучающиеся по направлению подготовки 45.03.02 «Лингвистика» (бакалавриат). На первом этапе происходило ознакомление с немецкой конкретной поэзией как явлением и творчеством наиболее ярких представителей этого жанра. Выделялись особенности конкретных текстов. К ним среди прочих относятся: нарушение языковых норм; эксперимент с шрифтами, с расположением слов и букв в пространстве; наличие пробелов и незаконченности формы; двусмысленность или многозначность. В конце первого этапа студенты написали текст, ориентируясь на образец. На втором этапе был создан оригинальный креативный продукт без опоры на какой-либо образец. После авторской редакции текст демонстрировался в группах по три-четыре человека с последующим обсуждением. Выделяются условия, при которых процесс создания текстов конкретной поэзии на иностранном языке будет проходить с большей эффективностью. Основная цель эксперимента достигнута – раскрыт методический потенциал конкретной поэзии, благодаря которой стало возможным повышение мотивации к обучению иноязычному письму, развитие творческой письменной речи на немецком языке.
The article considers the possibility of using methodological potential of concrete poetry for writing development in foreign language teaching at universities. The two-stage experiment of employing concrete poetry texts for teaching writing in German consisted of the reproductive stage and the productive stage. The teaching of creating poetic works was based on “from simple to complex” principle. At the reproductive stage students got acquainted with the genre of concrete poetry: its definition, history, traditions and the most prominent concrete poets. They focused on the original poetic work, imitated its structure. At the productive stage students created poetic works of their own. A survey was conducted among 3d and 4th year students majoring in Linguistics at the Department for the Humanities at Novosibirsk State Technical University. The paper gives recommendations on how to use concrete poetry texts in teaching writing skills at German lessons, provides examples of student’s works. Finally, the key findings are analyzed. The main purpose of the experiment is achieved: the methodological potential of concrete poetry is unleashed. The use of concrete poetry texts makes it possible to improve students’ motivation for writing in a foreign language, to develop creative skills, self-expression and self-knowledge and make writing in a foreign language more expressive and original.