bluuebunny/crossref_metadata_2025_split huggingface dataset:
The alternative bile acid pathway can predict food allergy persistence in early childhood
Authors: Lee So‐Yeon , Park Yoon Mee , Yoo Hyun Ju , Lee Seung‐Hwa , Choi Eom Ji , Baek Eun Young , Song Kun Baek , Yoon Jisun , Hong Soo‐Jong 
Published: August 2023

AbstractBackgroundMechanisms underlying persistent food allergy (FA) are not well elucidated. The intestinal mucosa is the primary exposure route of food allergens. However, no study has examined intestinal metabolites associated with FA persistence. The goal of this study was to investigate intestinal metabolites and associated microbiomes in early life that aid in determining the development and persistence of FA.MethodsWe identified metabolomic alterations in the stool of infants according to FA by mass spectrometry‐based untargeted metabolome profiling. The targeted metabolomic analysis of bile acid metabolites and stool microbiome was performed. Bile acid metabolite composition in infancy was evaluated by characterizing the subjects at the age of 3 into FA remission and persistent FA.ResultsIn untargeted metabolomics, primary bile acid biosynthesis was significantly different between subjects with FA and healthy controls. In targeted metabolomics for bile acids, intestinal bile acid metabolites synthesized by the alternative pathway were reduced in infants with FA than those in healthy controls. Subjects with persistent FA were also distinguished from healthy controls and those with FA remission by bile acid metabolites of the alternative pathway. These metabolites were negatively correlated with specific IgE levels in egg white. The abundance of intestinal Clostridia was decreased in the FA group and was correlated with ursodeoxycholic acid.ConclusionIntestinal bile acid metabolites of the alternative pathway could be predictive biomarkers for persistent FA in early childhood. These findings require replication in future studies.
STK4 deficiency and epidermodysplasia verruciformis‐like lesions: A case report
Authors: Gutierrez‐Marin Paula A. , Castano‐Jaramillo Lina M. , Velez‐Tirado Natalia , Villamil‐Osorio Milena , Patiño Esteban , Reina Maria Fernanda , Hernandez Maribel Trujillo 
Published: July 2023

AbstractSerine/threonine kinase 4 deficiency (STK4 or MST1, OMIM:614868) is an autosomal recessive (AR) combined immunodeficiency that can present with skin lesions such as epidermodysplasia verruciformis‐like lesions (EVLL). Herein, we describe a 17‐year‐old male patient born from consanguineous parents presenting with recurrent respiratory infections, verruciform plaques, poikiloderma, chronic benign lymphoproliferation, and Sjögren syndrome with suspected interstitial lymphocytic pneumonia.
Contrasting interactions of the aggressive Verticillium longisporum lineage A1/D1 and the non‐aggressive A1/D2 lineage with roots of oilseed rape
Authors: Vega‐Marin Marta , von Tiedemann Andreas 
Published: July 2023

AbstractVerticillium longisporum is a soilborne fungal vascular pathogen of Brassica crops. Three hybrid lineages originating from three independent hybridization events of four haploid Verticillium parents are known. V. longisporum lineage A1/D2 has only been found in horseradish and previous pathogenicity tests have shown that it is non‐aggressive on oilseed rape (Brassica napus). The aim of this study was to investigate the interaction of the non‐aggressive lineage A1/D2 with oilseed rape in comparison with the aggressive A1/D1 lineage. Although A1/D2 did not cause severe disease symptoms, the study revealed restricted root infection and systemic colonization by this lineage, as assessed by quantitative PCR of fungal DNA. Assessment of root surface colonization by confocal laser microscopy indicated early sporulation, disorganized loosely attached hyphal growth and hyphal coiling of A1/D2. By contrast, A1/D1 showed organized hyphal growth tight to the root surface, as well as hyphal swellings at points of penetration. Vascular colonization was studied with transmission electron microscopy, which revealed less vessel colonization, higher intensity of vascular responses and lower plant cell wall degradation in A1/D2‐treated plants in comparison with A1/D1. Vascular responses consisted of strong coating of vessel walls and fungal hyphae with an electron‐dense material, indicating higher intensity of plant defence in comparison with A1/D1. The results, for the first time, demonstrate stem colonization and thus a basic level of pathogenic interaction of non‐aggressive strains of A1/D2 with oilseed rape associated with a lack of severe disease symptoms, which indicate tolerance in oilseed rape to lineage A1/D2.
Enabling emergency production shifting: The value of blockchain in supply chain resilience confronting COVID‐19
Authors: Niu Baozhuang , Wang Lingfeng , Dong Jian 
Published: July 2023

AbstractNowadays, factories located in COVID‐19 infected countries/regions are facing random outbreaks. If blockchain is adopted, then the outbreaks can be known immediately and emergency production shifting can be enabled, although high crash cost will be incurred. Otherwise, production delay will become inevitable. We therefore formulate the tradeoffs among the high crash cost, the benefit from quick production, and the efficiency loss because of supply chain decentralization in a global brand's blockchain adoption decisions. We show that, in the presence of supply chain competition, the global brand will be benefited from blockchain adoption when the competition intensity degree is high, the crash cost is low, and the probability of COVID‐19 outbreak is high. We then verify the robustness of the main findings by studying the impact of the global brand's risk attitude, its overestimation of production delay, and the unexpected production delay in the low‐risk areas. In addition, we examine the social welfare and find it can also benefit from the global brand's blockchain adoption but the consumer surplus cannot.
Meaning of wellness in caring science based on Rodgers's evolutionary concept analysis
Authors: Eriksson Monica , Ekström‐Bergström Anette , Arvidsson Susann , Jormfeldt Henrika , Thorstensson Stina , Åström Ulrica , Lundgren Ingela , Roxberg Åsa 
Published: July 2023

AbstractBackgroundWellness is a holistic, multidimensional, and process‐oriented property on a continuum. It has been used interchangeably with and is undifferentiated from concepts such as health and well‐being without an in‐depth clarification of its theoretical foundations and a reflection on its meaning. The concept of wellness is frequently used, but its definition remains unclear.AimTo conceptually and theoretically explore the concept of wellness to contribute to a deeper understanding in caring science.MethodRodgers' evolutionary concept analysis was applied to the theoretical investigation of data from publications of international origins. The focus was on antecedents, attributes, consequences, surrogate and related terms, and contextual references. A literature search was performed through a manual review of reference lists and an online search in CINAHL and PubMed via EBSCO, and in ProQuest. Abstracts were examined to identify relevant studies for further review. The inclusion criteria were peer‐reviewed papers in English; papers published in scientific journals using the surrogate terms ‘wellness’, ‘health’, ‘health care’, and ‘health care and wellness’; and papers discussing and/or defining the concept of wellness. Twenty‐six studies met the inclusion criteria.ResultsBased on the findings from this concept analysis, a definition of wellness was developed: ‘a holistic and multidimensional concept represented on a continuum of being well that goes beyond health’. Implications for nursing practice were correspondingly presented.ConclusionWellness is defined as a holistic and comprehensive multidimensional concept represented on a continuum of being well, that goes beyond health. It calls attention by applying the salutogenic perspective to health promotion in caring science. It is strongly related to individual lifestyle and health behaviour and is frequently used interchangeably with health and well‐being without an in‐depth clarification of its theoretical foundation.
Aicardi–Goutières syndrome: A monogenic type I interferonopathy
Authors: Liu Anran , Ying Songcheng 
Published: July 2023

AbstractAicardi–Goutières syndrome (AGS) is a rare monogenic autoimmune disease that primarily affects the brains of children patients. Its main clinical features include encephalatrophy, basal ganglia calcification, leukoencephalopathy, lymphocytosis and increased interferon‐α (IFN‐α) levels in the patient's cerebrospinal fluid (CSF) and serum. AGS may be caused by mutations in any one of nine genes (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, IFIH1, LSM11 and RNU7‐1) that result in accumulation of self‐nucleic acids in the cytoplasm or aberrant sensing of self‐nucleic acids. This triggers overproduction of type I interferons (IFNs) and subsequently causes AGS, the prototype of type I interferonopathies. This review describes the discovery history of AGS with various genotypes and provides the latest knowledge of clinical manifestations and causative genes of AGS. The relationship between AGS and type I interferonopathy and potential therapeutic methods for AGS are also discussed in this review.
Changes in the suicide risk behaviors of American college students over time: An analysis of three universities
Authors: Barclay Nathan , Kelley Karen A. , Brausch Amy M. , Muehlenkamp Jennifer J. , Nadorff Michael R. 
Published: July 2023

AbstractIntroductionSuicide‐related behaviors are prevalent among college students, and several mental health problems associated with increased suicide risk have increased over time. Furthermore, notable cultural events (e.g., political changes, COVID‐19) have occurred in the past decade, which likely impact trends in suicide‐related behaviors. The current study examined how the prevalence of nonsuicidal self‐injury (NSSI), suicidal ideation (SI), and suicide attempts has changed from 2012 to 2022 across three different universities.MethodArchival datasets from multiple years of college student survey data were compiled, and different measures of NSSI, SI, and suicide attempts were dichotomized to assess prevalence. Chi‐square goodness‐of‐fit tests were used to identify changes in suicide‐related behaviors across time.ResultsResults indicated significant increases in the prevalence of most behaviors across each university, with most increases occurring after 2018. Despite sharing a general trend of increased suicide‐related behaviors, each university differed considerably in their respective trends between various timepoints, suggesting that unique factors may differentially contribute to growing risk among college students.ConclusionOverall, the current study identifies increasing trends in suicide‐related behaviors over the past decade and highlights the value of investigating these behaviors at the university level.
Cultural family processes, depressive symptoms, and suicidal ideation: A longitudinal study of Asian American youths
Authors: Lee Christina S. , Sin Esther J. , Park Michael , Okazaki Sumie , Choi Yoonsun 
Published: August 2023

AbstractIntroductionThis prospective study examined the direct and interactive effects of depressive symptoms and cultural family processes (i.e., intergenerational cultural conflict, academic parental control, cultural socialization parenting) on Asian American youths' suicidal ideation from adolescence to young adulthood.MethodsWe utilized three‐wave data of 408 Korean American and 378 Filipino American youths (M = 15.00 years, SD = 1.91 at Wave 1). For each ethnicity, we tested (1) whether depressive symptoms and cultural family processes predicted past‐year suicidal ideation; and (2) whether cultural family processes moderated the depressive symptom–suicidal ideation link.ResultsAcross ethnicities, depressive symptoms significantly predicted suicidal ideation after controlling for cultural family processes. For Filipino youths, intergenerational cultural conflict significantly predicted suicidal ideation after controlling depressive symptoms and exacerbated the depressive symptom–suicidal ideation link. For Filipino youths, depressive symptoms were significantly associated with suicidal ideation only at lower levels of cultural socialization parenting. For Korean youths, academic parental control exacerbated the depressive symptom–suicidal ideation link.ConclusionFindings suggest that while depressive symptoms have a robust effect on Asian American youths' suicidal ideation, this effect may be moderated by cultural family processes. Different findings for Korean and Filipino youths highlight the importance of disaggregating analyses by ethnicity to guide prevention efforts.
Continental and island arc segmentation: Implications for retro‐arc and pro‐arc foreland basin and backarc basin geometries and sediment distributions
Authors: Martin Keith 
Published: July 2023

AbstractSegmented magmatic arcs create arc‐parallel variable loads and influence associated foreland basins through flexural isostasy along strike, in addition to standard subduction‐perpendicular foredeep/forebulge/backbulge models. Segmentation occurs in both continental and island arcs (Aleutians, Calabria, Japan, Kuril/Kamchatka, Lesser Antilles, Solomon Islands and Sumatra/Java). Some segments have variable gravity anomalies and elastic thicknesses (Te). In standard theory, the load created by an orogenic belt/magmatic arc depresses the lithosphere modelled as a thin elastic plate floating on a fluid mantle substrate, leading to an arc‐perpendicular foredeep, forebulge and backbulge. Arc‐parallel topographic and gravitational features should influence loading along strike in a similar way, resulting in a checkerboard pattern of foredeeps, forebulges and backbulges in both pro‐arc and retro‐arc foreland basins. This pattern exercises profound controls on sediment and facies distribution in a here‐to‐fore un‐envisaged manner, with implications for resource exploration in foreland basins.
Disentangling Land Financialisation: Insights from Santiago de Chile's Land Lease‐Purchase Contracts
Authors: Gasic Ivo 
Published: August 2023

AbstractNon‐depreciation gives to land a central role in the credit expansion process of the modern economy and constitutes the foundation of the relationship between finance and real estate. To understand the process by which land becomes an underlying asset in the financial market, this paper's theoretical model formalises a set of propositions derived from asset price theory and real options theory. Theoretically, vacant land speculation results from rational behaviour; thus, land becomes valued as a real investment option. This real option can later operate as an underlying asset for credits and financial options, which explains the financialisation of vacant land. This work evidences the process of formation of landbanks by insurance companies in Santiago, Chile, showing that their acquisitions are, partly, carried out via Lease‐Purchase Contracts. Besides, it is demonstrated that Lease‐Purchase Contracts tend to locate in geographical areas with greater growth rate in land price and deviations in this rate.
Does therapeutic drug monitoring (TDM) of trough concentrations suffice for optimizing preemptive therapy with ganciclovir of cytomegalovirus infections in non‐renal solid organ transplant recipients?
Authors: Gatti Milo , Rinaldi Matteo , Potena Luciano , Salvaterra Elena , Morelli Maria Cristina , Giannella Maddalena , Viale Pierluigi , Pea Federico 
Published: July 2023

AbstractObjectivesThe aim of this study is to explore the relationship between ganciclovir exposure and clinical efficacy and/or safety in non‐renal solid organ transplant (SOT) recipients receiving preemptive therapy with ganciclovir/valganciclovir and undergoing therapeutic drug monitoring (TDM)‐guided dosing optimization.MethodsNon‐renal SOT recipients admitted to IRCCS Azienda Ospedaliero‐Universitaria of Bologna receiving preemptive therapy with ganciclovir or valganciclovir for active cytomegalovirus (CMV) infection and who underwent at least one TDM were included. Desired ganciclovir Cmin range was set at 1–3 mg/L, and average ganciclovir trough concentrations (Cmin) were calculated for each patient. Reduced CMV viral load below the lower limit of quantification (LLQ) at 30 days and occurrence of myelotoxicity were selected as the primary outcome. Univariate analysis was performed by comparing patients with average Cmin below or above 1 or 3 mg/L. Receiver operating characteristic (ROC) curve analysis was performed to identify the average ganciclovir Cmin cut‐off predictive for clinical efficacy or toxicity.ResultsTwenty‐nine out of 89 retrieved patients met the inclusion criteria, with a median (interquartile [IQR]) baseline CMV viral load of 27,163 copies/mL (IQR 13 159.75–151 340.25 copies/mL). Reduced CMV viral load below the LLQ at 30 days was found in 17 patients (58.6%). No difference was found in the primary outcome between patients showing average Cmin below or above 1 mg/L (100.0% vs. 53.8%; p = .25) and/or 3 mg/L (65.2% vs. 33.3%; p = .20). ROC analysis did not allow to identify an average Cmin cut‐off predictive of clinical efficacy or toxicity.ConclusionsNo clear relationship between ganciclovir Cmin and neither CMV eradication nor safety issues was identified.
image
Draft genome sequence of
Lactobacillus helveticus
OSU-BDGOAK2 and
Lactobacillus kefiranofaciens
OSU-BDGOA1, kefir grain isolates with potential antibacterial activity
Authors: González-Orozco Brianda D. , Santiago-Rodriguez Tasha M. , García-Cano Israel , Jiménez-Flores Rafael , Alvarez Valente B. 
Published: August 2023

ABSTRACT

We present the draft genome sequence and assembly of
Lactobacillus helveticus
OSU-BDGOAK2 and
Lactobacillus kefiranofaciens
OSU-BDGOA1 isolated from kefir grains that exhibited
in vitro
antibacterial activity against
Escherichia coli
ATCC 25922,
Listeria innocua
ATCC 51742, and
Staphylococcus epidermidis
ATCC 1222. Genome analysis of both strains revealed gene clusters encoding bacteriocins.
Extensive cellular multi-tasking within
Bacillus subtilis
biofilms
Authors: Yannarell Sarah M. , Beaudoin Eric S. , Talley Hunter S. , Schoenborn Alexi A. , Orr Galya , Anderton Christopher R. , Chrisler William B. , Shank Elizabeth A. 
Published: August 2023

ABSTRACT

Bacillus subtilis
is a soil-dwelling bacterium that can form biofilms, or communities of cells surrounded by a self-produced extracellular matrix. In biofilms, genetically identical cells often exhibit heterogeneous transcriptional phenotypes, so that subpopulations of cells carry out essential yet costly cellular processes that allow the entire population to thrive. Surprisingly, the extent of phenotypic heterogeneity and the relationships between subpopulations of cells within biofilms of even in well-studied bacterial systems like
B. subtilis
remains largely unknown. To determine relationships between these subpopulations of cells, we created 182 strains containing pairwise combinations of fluorescent transcriptional reporters for the expression state of 14 different genes associated with potential cellular subpopulations. We determined the spatial organization of the expression of these genes within biofilms using confocal microscopy, which revealed that many reporters localized to distinct areas of the biofilm, some of which were co-localized. We used flow cytometry to quantify reporter co-expression, which revealed that many cells “multi-task,” simultaneously expressing two reporters. These data indicate that prior models describing
B. subtilis
cells as differentiating into specific cell types, each with a specific task or function, were oversimplified. Only a few subpopulations of cells, including surfactin and plipastatin producers, as well as sporulating and competent cells, appear to have distinct roles based on the set of genes examined here. These data will provide us with a framework with which to further study and make predictions about the roles of diverse cellular phenotypes in
B. subtilis
biofilms.

IMPORTANCE

Many microbes differentiate, expressing diverse phenotypes to ensure their survival in various environments. However, studies on phenotypic differentiation have typically examined only a few phenotypes at one time, thus limiting our knowledge about the extent of differentiation and phenotypic overlap in the population. We investigated the spatial organization and gene expression relationships for genes important in
B. subtilis
biofilms. In doing so, we mapped spatial gene expression patterns and expanded the number of cell populations described in the
B. subtilis
literature. It is likely that other bacteria also display complex differentiation patterns within their biofilms. Studying the extent of cellular differentiation in other microbes may be important when designing therapies for disease-causing bacteria, where studying only a single phenotype may be masking underlying phenotypic differentiation relevant to infection outcomes.
Laramide bulldozing of lithosphere beneath the Arizona transition zone, southwestern United States
Authors: Kapp Paul , Jepson Gilby , Carrapa Barbara , Schaen Allen J. , He John J.Y. , Wang Jordan W. 
Published: August 2023

Abstract
The northwest-trending transition zone (TZ) in Arizona (southwestern United States) is an ~100-km-wide physiographic province that separates the relatively undeformed southwestern margin of the Colorado Plateau from the hyperextended Basin and Range province to the southwest. The TZ is widely depicted to have been a Late Cretaceous–Paleogene northeast-dipping erosional slope along which Proterozoic rocks were denuded but not significantly deformed. Our multi-method thermochronological study (biotite 40Ar/39Ar, zircon and apatite [U-Th-Sm]/He, and apatite fission track) of Proterozoic rocks in the Bradshaw Mountains of the west-central Arizona TZ reveals relatively rapid cooling (~10 °C/m.y.) from temperatures of &gt;180 °C to &lt;60 °C between ca. 70 and ca. 50 Ma. Given minimal ca. 70–50 Ma upper-crustal shortening in the TZ, we attribute cooling to exhumation driven by northeastward bulldozing of continental lower crust and mantle lithosphere beneath it by the Farallon flat slab. Bulldozing is consistent with contemporaneous (ca. 70–50 Ma) underplating and initial exhumation of Orocopia Schist to the southwest in western Arizona and Mesozoic garnet-clinopyroxenite xenoliths of possible Mojave batholith keel affinity in ca. 25 Ma TZ volcanic rocks.