bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainability in the supply chain – understanding suppliers’ resource allocation for sustainability issues
Authors: Ingenbleek Paul T.M. , Krampe Caspar 
Published: April 2023

Purpose
As corporate sustainability is systemic, it cannot be achieved without effective involvement of suppliers. This study aims to examine the drivers of supplier companies’ resource allocation to a sustainability issue that affects customer companies and society at large.

Design/methodology/approach
Supplier companies’ resource allocation for a sustainability issue is explained from variables at the levels of the institutional, supply chain and internal environments of a supplier company. The framework is tested with a moderated regression model on 102 supplier companies in animal-based supply chains, focussing on their resource allocation for farm animal welfare.

Findings
The findings show that supply chain factors have the strongest influence on suppliers’ resource allocation, including a strong effect of investment specificity and a U-shaped effect of chain integration. Also, significant effects from institutional variables, namely, the pressure on consumer companies, and an inverted U-shaped effect of sustainability competition are found. The innovativeness, referring to the internal environment of supplier companies, appears as another important factor for the allocation of resources to animal welfare, as a sustainability issue.

Research limitations/implications
The results have implications for consumer market companies to deal with sustainability issues that require involvement of their suppliers, for supplier companies to increase their competitive positions and strengthen their relationships within the supply chain, and for policymakers seeking solutions for sustainability issues in the market domain.

Originality/value
While existing literature focusses mostly on the corporate sustainability of highly visible and large consumer companies, to the best of the authors’ knowledge, this study is the first to examine the drivers of supplier companies’ resource allocation for a sustainability issue, namely, animal welfare. It provides insights on what drives supplier companies, usually operating outside the spotlight, to become part of a sustainability transition.
Geochronology and Geochemistry of Early Cretaceous A‐type Granites in Central–Eastern Inner Mongolia, China: Implications for Late Mesozoic Tectonic Evolution of the Southern Great Xing'an Range
Authors: ZHANG Yanwen , ZHANG Xiaofei , CHEN Lixin , PANG Zhenshan , CHEN Hui , XUE Jianling , ZHOU Yi , TENG Chao , CHEN Guochao 
Published: April 2023

AbstractThe southern Great Xing'an Range is the most critical Sn‐polymetallic metallogenic belt in northeast China. However, the tectonic setting of the Early Cretaceous magmatic‐metallogenic “flare‐up” event remains uncertain. This paper presents an integrated study on the occurrence, petrology, zircon U‐Pb ages, whole‐rock geochemistry, and in situ zircon Hf isotopes for Wenduerchagan granites of Xi Ujimqin Banner, central‐eastern Inner Mongolia. These granites consist primarily of granite porphyry (with ages of 137 ± 1 Ma and 138 ± 1 Ma) and (porphyritic) alkali feldspar granite (with an age of 141 ± 2 Ma), corresponding to the early Early Cretaceous. They are A‐type granites characterized by high silicon, alkali, and TFeO/MgO contents while being depleted of Ba, Nb, Ta, Sr, P, and Ti. They show right‐dipping trend rare‐earth element distribution characteristics with negative Eu anomalies (Eu/Eu* = 0.01–0.20) and weak heavy rare‐earth element fractionation ((Gd/Yb)N = 0.77–2.30). They demonstrate homogeneous zircon Hf isotopic compositions (positive εHf(t) values from +5.3 to +7.1 and young two‐stage Hf model ages of 851–742 Ma) and high zircon saturation temperatures (av. 810°C). These geochemical characteristics indicate that Wenduerchagan granites originated from the partial melting of juvenile crust under high‐temperature and low‐pressure conditions. Wenduerchagan granites most likely formed in a post‐collisional compression‐extension transition regime caused by the closure of the Mongol–Okhotsk Ocean, when combined with regional geology. Such a transition regime can probably be attributed to the upwelling of the asthenospheric mantle caused by the break‐off of a subducted Mongol–Okhotsk oceanic slab. Upwelling asthenospheric mantle provided sufficient energy and favorable tectonic conditions for magmatism and mineralization of the Early Cretaceous.
Right‐sided vocal cord paralysis following stereotactic body radiation therapy for non–small‐cell lung cancer: A case report
Authors: Kanaoka Kensuke , Fukuda Shoich , Inagaki Yuji , Taniguchi Yoshihiko , Nakao Keiko , Tamiya Akihiro , Matsuda Yoshinobu , Okishio Kyoichi 
Published: April 2023

AbstractVocal code paralysis (VCP) is a rare complication of stereotactic body radiation therapy (SBRT). In most previously reported cases of VCP after SBRT, VCP was left‐sided because of anatomic vulnerability. Here, we report a case of right‐sided VCP following SBRT for non–small‐cell lung cancer. The patient was an 81‐year‐old man who underwent SBRT for synchronous lung cancer of the right upper and inferior lobes. He subsequently developed radiation pneumonitis and received corticosteroids. Lung contraction persisted, and the mediastinum shifted to the right because of lung volume reduction. After corticosteroids discontinuation, the patient developed hoarseness and voice weakness. An endoscopic test showed right‐sided VCP. Imaging examinations did not reveal new lesions, including lung cancer recurrence. Therefore, we diagnosed the patient with SBRT‐associated VCP and speculated that the injury to the right vagal nerve and recurrent laryngeal nerve resulted from mechanical traction due to intense lung contraction, which might have induced VCP. We should be alert to VCP following SBRT, even if the target lesions are right‐sided.
Adiponectin reverses β‐Cell damage and impaired insulin secretion induced by obesity
Authors: Munhoz Ana Cláudia , Serna Julian D. C. , Vilas‐Boas Eloisa Aparecida , Caldeira da Silva Camille C. , Santos Tiago G. , Mosele Francielle C. , Felisbino Sergio L. , Martins Vilma Regina , Kowaltowski Alicia J. 
Published: April 2023

AbstractObesity significantly decreases life expectancy and increases the incidence of age‐related dysfunctions, including β‐cell dysregulation leading to inadequate insulin secretion. Here, we show that diluted plasma from obese human donors acutely impairs β‐cell integrity and insulin secretion relative to plasma from lean subjects. Similar results were observed with diluted sera from obese rats fed ad libitum, when compared to sera from lean, calorically restricted, animals. The damaging effects of obese circulating factors on β‐cells occurs in the absence of nutrient overload, and mechanistically involves mitochondrial dysfunction, limiting glucose‐supported oxidative phosphorylation and ATP production. We demonstrate that increased levels of adiponectin, as found in lean plasma, are the protective characteristic preserving β‐cell function; indeed, sera from adiponectin knockout mice limits β‐cell metabolic fluxes relative to controls. Furthermore, oxidative phosphorylation and glucose‐sensitive insulin secretion, which are completely abrogated in the absence of this hormone, are restored by the presence of adiponectin alone, surprisingly even in the absence of other serological components, for both the insulin‐secreting INS1 cell line and primary islets. The addition of adiponectin to cells treated with plasma from obese donors completely restored β‐cell functional integrity, indicating the lack of this hormone was causative of the dysfunction. Overall, our results demonstrate that low circulating adiponectin is a key damaging element for β‐cells, and suggest strong therapeutic potential for the modulation of the adiponectin signaling pathway in the prevention of age‐related β‐cell dysfunction.
Serum keratin 18‐M65 levels detect progressive forms of alcohol‐associated liver disease in early noncirrhotic stages
Authors: Maccioni Luca , Horsmans Yves , Leclercq Isabelle , Schnabl Bernd , Stärkel Peter 
Published: April 2023

AbstractBackground and AimsThe progression of alcohol‐associated liver disease (ALD) in its early precirrhotic stages can be a silent process. Serum keratin 18 levels (K18‐M65) predict severe events and mortality in advanced stages of ALD, but data on this biomarker in early stages are scarce. We evaluated the diagnostic accuracy of K18‐M65 levels in identifying early forms of ALD.MethodsWe prospectively evaluated two cohorts of actively drinking patients with alcohol use disorder (AUD) following a rehabilitation program (training (n = 162) and validation (n = 78)) and matched healthy controls (n = 21). Clinical, laboratory, and imaging data were used to distinguish AUD patients with simple steatosis (minimal ALD) and steatohepatitis/fibrosis (early ALD). We measured serum K18‐M65 levels and assessed their ability to predict early ALD.ResultsHigh levels of K18‐M65 characterized AUD patients with early ALD, while levels in the minimal ALD group were similar to those in healthy controls. K18‐M65 levels distinguished minimal liver disease from early ALD (AUROC = 0.8704; p < 0.0001) with an optimal cutoff at 265.9 U/L. K18‐M65 levels strongly correlated with transaminases and predicted early ALD (OR 25.81; 95% CI 3.166–336.1; p < 0.0001), controlled attenuation parameter, and liver stiffness independently from transaminases and other potential confounders. K18‐M65 levels did not discriminate between fibrosis and steatohepatitis but correlated with histological signs of hepatocellular injury and inflammation (all p < 0.05). The K18‐M65 cutoff detected early ALD in the validation cohort with high accuracy (sensitivity 86.67%, specificity 96.67%) and a very high positive likelihood ratio (28.6; 95% CI 4.14–197.73).ConclusionsSerum K18‐M65 levels can be used as a biomarker to detect early ALD stages with excellent predictive value.
Autophosphorylation of αCaMKII regulates alcohol consumption by controlling sedative effects of alcohol and alcohol‐induced loss of excitatory synapses
Authors: Cały Anna , Ziółkowska Magdalena , Pagano Roberto , Salamian Ahmad , Śliwińska Małgorzata A. , Sotoudeh Narges , Bernaś Tytus , Radwanska Kasia 
Published: April 2023

AbstractCalcium/calmodulin‐dependent kinase II (CaMKII) is a key enzyme at the glutamatergic synapses. CAMK2A gene variants have been linked with alcohol use disorder (AUD) by an unknown mechanism. Here, we looked for the link between αCaMKII autophosphorylation and the AUD aetiology. Autophosphorylation‐deficient heterozygous αCaMKII mutant mice (T286A+/−) were trained in the IntelliCages to test the role of αCaMKII activity in AUD‐related behaviours. The glutamatergic synapses morphology in CeA was studied in the animals drinking alcohol using 3D electron microscopy. We found that T286A+/− mutants consumed less alcohol and were more sensitive to sedating effects of alcohol, as compared to wild‐type littermates (WT). After voluntary alcohol drinking, T286A+/− mice had less excitatory synapses in the CeA, as compared to alcohol‐naive animals. This change correlated with alcohol consumption was not reversed after alcohol withdrawal and not observed in WT mice. Our study suggests that αCaMKII autophosphorylation affects alcohol consumption by controlling sedative effects of alcohol and preventing synaptic loss in the individuals drinking alcohol. This finding advances our understanding of the molecular processes that regulate alcohol dependence.
Assessment of dupilumab in children with moderate‐to‐severe type 2 asthma with or without evidence of allergic asthma
Authors: Papadopoulos Nikolaos G. , Szefler Stanley J. , Bacharier Leonard B. , Maspero Jorge F. , Domingo Christian , Fiocchi Alessandro , Lee Jason K. , Daizadeh Nadia , Lederer David J. , Hardin Megan , Gall Rebecca , Djandji Michel , Siddiqui Shahid , Jacob‐Nara Juby A. , Deniz Yamo , Rowe Paul J. 
Published: April 2023

AbstractBackgroundCytokines, such as interleukins (IL)‐4/5/13, play a key role in multiple type 2 inflammatory diseases, including allergic asthma. Dupilumab, a human monoclonal antibody, blocks the shared receptor component for IL‐4/IL‐13, inhibiting signaling. In this post hoc analysis of VOYAGE (NCT02948959), dupilumab efficacy was evaluated in patients aged 6–11 years with type 2 asthma with or without evidence of allergic asthma (baseline serum total IgE ≥30 IU/mL and ≥1 perennial aeroallergen‐specific IgE ≥0.35kU/L).MethodsAnnualized severe exacerbation rates (AER) and changes in pre‐bronchodilator (Pre‐BD) forced expiratory volume in one second (FEV1), percent‐predicted pre‐BD FEV1 (ppFEV1), and Asthma Control Score (ACQ)‐7 were assessed during the treatment period.Results350 children (261 with and 89 without evidence of allergic asthma) were included. Dupilumab versus placebo significantly reduced AER in patients with (0.24 vs. 0.62, relative risk reduction [RRR]: 62% [95% CI, 39–76], P < .0001) and without (0.39 vs. 0.80, RRR: 51% [95% CI, 0–76], P < .05) evidence of allergic asthma. Significant improvements in ppFEV1, pre‐bronchodilator FEV1, and ACQ‐7 scores were observed in dupilumab versus placebo throughout the treatment period in patients with evidence of allergic asthma. In patients without evidence of allergic asthma, numerical improvements in pre‐bronchodilator FEV1 and asthma control were observed by Week 52.ConclusionDupilumab versus placebo reduced asthma exacerbations in children with type 2 asthma irrespective of evidence of allergic asthma; similar trends were observed in changes in lung function. Significant improvement in asthma control was observed in patients with evidence of allergic asthma, but not in those without.
Assessing the interplay between Open Innovation and Sustainability‐Oriented Innovation: A systematic literature review and a research agenda
Authors: Urbinati Andrea , Shams Esfandabadi Zahra , Messeni Petruzzelli Antonio 
Published: April 2023

AbstractOpen Innovation and Sustainability‐Oriented Innovation are undoubtedly two of the most debated topics of the last decades, gaining the interest of policymakers, practitioners, and scholars all over the world. Even if they have been usually described as two independent research fields, there are some emblematic examples presenting interplay and synergy between these topics, represented either by the hybrid perspectives ofOpen Sustainable Innovation, that is, the Open Innovation approach acting as an enabler of Sustainability‐Oriented Innovation, andSustainable Open Innovation, which instead analyzes how firms developing Sustainability‐Oriented Innovation also adopt the Open Innovation approach. On the basis of these two perspectives and through a systematic literature review, this paper investigates the relationships between the Open Innovation and Sustainability‐Oriented Innovation approaches and frames these relationships by developing an innovative framework, which highlights the main aspects characterizing the hybrid perspectives ofOpen Sustainable InnovationandSustainable Open Innovation. The proposed framework highlights the Open Innovation practices and strategies enabling Sustainability‐Oriented Innovation, as well as the contextual factors enabling both practices and strategies for Sustainability‐Oriented Innovation. In addition, it shows how firms developing Sustainability‐Oriented Innovation have a similar orientation toward the adoption of the Open Innovation approach both in terms of how they engage stakeholders, and the innovation capabilities they develop. Finally, a research agenda identifying the central issues and the key research gaps is offered for further development in future studies.
Preterm birth among Pacific Islanders in the United States and the US‐affiliated Pacific Islands: A systematic review and meta‐analysis
Authors: Wu Bohao , Arslanian Kendall J. , Nyhan Kate , Suss Rachel , Mahoney Madison , McElfish Pearl A. , Muasau‐Howard Bethel T. , Ekeroma Alec , Hawley Nicola L. 
Published: April 2023

AbstractObjectiveTo better understand the epidemiology of preterm birth among Pacific Islanders in the United States and the US‐Affiliated Pacific Islands.MethodsSystematic searches of MEDLINE, Embase, CINAHL, PsycINFO, two nonindexed regional journals, and gray literature were conducted and finalized in September 2021. Observational studies published since January 2010 that documented preterm birth outcomes among Pacific Islanders in the United States and the US‐Affiliated Pacific Islands were eligible for inclusion. Outcomes of interest included preterm birth prevalence, risk compared with white women, and risk factors for preterm birth among Pacific Islanders.ResultsFourteen of the 3183 screened articles were included in meta‐analyses. Random‐effects models were used for pooled estimates with 95% confidence intervals. The pooled prevalence of preterm birth among Pacific Islanders was 11.2%, 95% CI: 9.3%‐13.6%. Marshallese women had the highest pooled prevalence (20.7%, 95% CI 18.6%‐23.0%) among Pacific Islander subgroups. Compared with white women, Pacific Islander women had higher odds of experiencing preterm birth (OR = 1.40, 95% CI: 1.28‐1.53). Four risk factors for preterm birth could be explored with the data available: hypertension, diabetes, smoking, and pre‐pregnancy body mass index; hypertension and diabetes significantly increased the odds of preterm birth.ConclusionsExisting literature suggests that United States Pacific Islanders were more likely to experience preterm birth than white women, although the pooled prevalence varied by Pacific Islander subgroup. Data support the need for disaggregation of Pacific Islanders in future research and argue for examination of subgroup‐specific outcomes to address perinatal health disparities.
A positive TGF‐β/miR‐9 regulatory loop promotes the expansion and activity of tumour‐initiating cells in breast cancer
Authors: Liu Yichen , Chen Ying , Zhao Qiong , Xie Tianyuan , Xiang Chenxi , Guo Qianqian , Zhang Wenzhou , Zhou Yi , Yuan Yin , Zhang Yuxin , Xi Tao , Li Xiaoman , Zheng Lufeng 
Published: April 2023

Background and PurposeMicroRNA‐9 (miR‐9) has previously been described as a dual‐functional RNA during breast cancer progression and its roles need to be clarified thoroughly.Experimental ApproachA miR‐9 knockout mode of mouse breast cancer, the MMTV‐PyMT model (PyMT‐miR‐9−/−), combined with different human breast cancer cell lines were used to evaluate the effects of miR‐9 on breast cancer initiation, progression and metastasis. Lin‐NECs (Neoplastic mammary epithelial cells) and pNECs (Pre‐neoplastic mammary epithelial cells) were isolated and subjected to tumour‐initiation assay. Whole‐mount staining of mammary gland and histology was performed to determine mammary gland growth. Tumour‐initiating analysis combining a series of in vitro experiments were carried out to evaluate miR‐9 roles in tumour‐initiating ability. RNA‐sequencing of human breast cancer cells, and mammary glands at hyperplastic stages and established tumours in PyMT and PyMT‐miR‐9−/− mice, ChIP and luciferase report assays were conducted to reveal the underlying mechanisms.Key ResultsMiR‐9 is ectopically expressed in breast cancer and its level is negatively correlated with the prognosis, especially in basal‐like breast cancer patients. Additionally, miR‐9 is essential for breast cancer progression by promoting the expansion and activity of tumour‐initiating cells (TICs) in preneoplastic glands, established tumours and xenograft modes. Mechanistically, the activity of TICs hinges on a positive TGF‐β/miR‐9 regulatory loop mediated by the STARD13/YAP axis.Conclusions and ImplicationsThese findings demonstrate that miR‐9 is an oncogenic miRNA rather than a tumour‐suppressor in breast cancer, calling for rectification of the model for this conserved and highly abundant miRNA.
Tube‐in‐tube endoscopic vacuum therapy for treatment of colorectal anastomotic leaks: A low‐cost, patient‐friendly, feasible and efficient technical modification of sponge‐based endoscopic vacuum therapy
Authors: de Lima Marcelo Simas , Figueiredo Lucas Zouain , Furuya Carlos Kiyoshi , Pombo Amanda Aquino de Miranda , Hora Jose Americo Bacchi , Malluf‐Filho Fauze 
Published: April 2023

AbstractBackground and AimsColorectal endoscopic vacuum therapy (CR EVT) is usually performed using sponges passed through the anus. It may be associated with patient discomfort and displacement of the aspiration tube.MethodsWith the tube‐in‐tube endoscopic vacuum therapy modification (CR TT‐EVT), it is possible to position the aspiration tube in the pelvic cavity through the abdominal wall. In addition, it allows frequent cleaning of the fistula, eliminates the need for programmed device changes, and enables a standardized approach to such a wide variety of fistulas, leaks, and perforations.ResultsHere is a technical note on how to perform CR TT‐EVT, while we are at the early phase of our case series we have reached 100% of technical success.
Extreme learning machine algorithm‐based model for lung cancer classification from histopathological real‐time images
Authors: Grace John M. , Baskar S. 
Published: April 2023

AbstractIn the present scenario, developing an automatic and credible diagnostic system to analyze lung cancer type, stage, and level from computed tomography (C.T.) images is a very challenging task, even for experienced pathologists, due to the nonuniform illumination and artifacts. The nonuniform illumination and artifacts are the low‐frequency changes in image intensity that arise from the sensor and the person's movement while recording the C.T. scanned images. Although numerous machine learning techniques are used to improve the effectiveness of automatic lung cancer diagnostic systems, the classification accuracy of these systems still needs significant improvement to satisfy the real‐time requirement of the diagnostic situations. A new extreme learning machine (ELM) algorithm‐based model (hereafter called XlmNet) is proposed to classify the histopathology scans effectively. XlmNet utilizes The Cancer Imaging Archive (TCIA) dataset. After data collection, the initial stage in XlmNet is preprocessing, including noise removal, histogram equalization, and quality‐improved image. The enhanced Profuse Clustering (EPC) method is implemented for segmenting the affected regions from C.T. scans by image segment using superpixel clustering. The statistical attributes are extracted by using Principal Component Analysis (PCA). ELM classifier helps in classifying the lung nodules. The empirical results of the XlmNet model are related to some advanced classifiers concerning performance metrics. The evaluations of XlmNet on the TCIA dataset reveal that XlmNet outperforms other classification networks with the Accuracy of 0.965, a sensitivity of 0.964, a specificity of 0.865, a precision of 0.962, a Jaccard similarity score (JSS) of 0.95.