bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lenvatinib plus anti-PD-1 antibodies as conversion therapy for patients with unresectable intermediate-advanced hepatocellular carcinoma: a single-arm, phase II trial
Authors: Zhang Wenwen , Tong Shuang , Hu Bingyang , Wan Tao , Tang Haowen , Zhao Feilong , Jiao Tianyu , Li Junfeng , Zhang Ze , Cai Jinping , Ye Huiyi , Wang Zhanbo , Chen Shiqing , Wang Yafei , Li Xuerui , Wang Fangzhou , Cao Junning , Tian Lantian , Zhao Xiaochen , Chen Mingyi , Wang Hongguang , Cai Shouwang , Hu Minggen , Bai Yuezong , Lu Shichun 
Published: September 2023

BackgroundOver 70% of the patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage and lose the opportunity for radical surgery. Combination therapy of tyrosine kinase inhibitors (TKIs) and anti-programmed cell death protein-1 (PD-1) antibodies has achieved a high tumor response rate in both the first-line and second-line treatment of advanced HCC. However, few studies have prospectively evaluated whether TKIs plus anti-PD-1 antibodies could convert unresectable intermediate-advanced HCC into resectable disease.MethodsThis single-arm, phase II study enrolled systemic therapy-naïve adult patients with unresectable Barcelona Clinic Liver Cancer stage B or C HCC. Patients received oral lenvatinib one time per day plus intravenous anti-PD-1 agents every 3 weeks (one cycle). Tumor response and resectability were evaluated before the fourth cycle, then every two cycles. The primary endpoint was conversion success rate by investigator assessment. Secondary endpoints included objective response rate (ORR) by independent imaging review (IIR) assessment per modified RECIST (mRECIST) and Response Evaluation Criteria in Solid Tumors, V.1.1 (RECIST 1.1), progression-free survival (PFS) and 12-month recurrence-free survival (RFS) rate by IIR per mRECIST, R0 resection rate, overall survival (OS), and safety. Biomarkers were assessed as exploratory objectives.ResultsOf the 56 eligible patients enrolled, 53 (94.6%) had macrovascular invasion, and 16 (28.6%) had extrahepatic metastasis. The median follow-up was 23.5 months. The primary endpoint showed a conversion success rate of 55.4% (31/56). ORR was 53.6% per mRECIST and 44.6% per RECIST 1.1. Median PFS was 8.9 months, and median OS was 23.9 months. Among the 31 successful conversion patients, 21 underwent surgery with an R0 resection rate of 85.7%, a pathological complete response rate of 38.1%, and a 12-month RFS rate of 47.6%. Grade ≥3 treatment-related adverse events were observed in 42.9% of patients. Tumor immune microenvironment analysis of pretreatment samples displayed significant enrichment of CD8+T cells (p=0.03) in responders versus non-responders.ConclusionLenvatinib plus anti-PD-1 antibodies demonstrate promising efficacy and tolerable safety as conversion therapy in unresectable HCC. Pre-existing CD8+cells are identified as a promising biomarker for response to this regimen.Trial registration numberChinese Clinical Trial Registry, ChiCTR1900023914.
Sex and anti-inflammatory treatment affect outcome of melanoma and non-small cell lung cancer patients with rheumatic immune-related adverse events
Authors: Gente Karolina , Diekmann Leonore , Daniello Lea , Will Julia , Feisst Manuel , Olsavszky Victor , Günther Janine , Lorenz Hanns-Martin , Souto-Carneiro M Margarida , Hassel Jessica C , Christopoulos Petros , Leipe Jan 
Published: September 2023

BackgroundRheumatic immune-related adverse events (R-irAEs) occur in 5–15% of patients receiving immune checkpoint inhibitors (ICI) and, unlike other irAEs, tend to be chronic. Herein, we investigate the factors influencing cancer and R-irAEs outcomes with particular focus on adverse effects of anti-inflammatory treatment.MethodsIn this prospective, multicenter, long-term, observational study, R-irAEs were comprehensively analyzed in patients with malignant melanoma (MM, n=50) and non-small cell lung cancer (NSCLC, n=41) receiving ICI therapy who were enrolled in the study between August 1, 2018, and December 11, 2022.ResultsAfter a median follow-up of 33 months, progressive disease or death occurred in 66.0% and 30.0% of MM and 63.4% and 39.0% of patients with NSCLC. Male sex (progression-free survival (PFS): p=0.013, and overall survival (OS): p=0.009), flare of a pre-existing condition (vs de novo R-irAE, PFS: p=0.010) and in trend maximum glucocorticoid (GC) doses >10 mg and particularly ≥1 mg/kg prednisolone equivalent (sex-adjusted PFS: p=0.056, OS: p=0.051) were associated with worse cancer outcomes. Patients receiving disease-modifying antirheumatic drugs (DMARDs) showed significantly longer PFS (n=14, p=0.011) and OS (n=20, p=0.018). Effects of these variables on PFS and/or OS persisted in adjusted Cox regression models. Additionally, GC treatment negatively correlated with the time from diagnosis of malignancy and the latency from ICI start until R-irAE onset (all p<0.05). R-irAE features and outcomes were independent of other baseline patient characteristics in both studied cancer entities.ConclusionMale sex, flare of pre-existing rheumatologic conditions and extensive GC treatment appeared to be linked with unfavorable cancer outcomes, while DMARD use had a favorable impact. These findings challenge the current dogma of restrictive DMARD use for R-irAE and thus may pave the way to better strategies and randomized controlled trials for the growing number of patients with R-irAE.
Impact of the COVID-19 pandemic on CVD prevention between different socioeconomic groups in Switzerland
Authors: Maung Ko Ko , Marques-Vidal Pedro 
Published: September 2023

BackgroundThe COVID-19 pandemic disrupted the continuing management of cardiovascular disease (CVD) risk factors in the population. Socioeconomic status (SES) is a major determinant of health. Whether the COVID-19 pandemic increased, the SES gap in CVD risk factors is unknown.AimsTo compare the management of CVD risk factors and the SES gap before and during the pandemic.MethodsCross-sectional study conducted between 2018 and 2021 in Lausanne, Switzerland. Prevalence, awareness, treatment and control rates of hypertension, dyslipidaemia and diabetes were compared between the periods before (N=2416, 45.2% men, 65.3±9.8 years) and during (N=776, 44.5% men, 63.9±9.1 years) the COVID-19 pandemic. SES was defined by education and categorised as low (compulsory or apprenticeship), middle (high school) and high (university).ResultsAfter multivariable analysis, the prevalence of hypertension increased, and awareness decreased during the pandemic: OR and (95% CI) 1.26 (1.04 to 1.53) and 0.70 (0.53 to 0.94), respectively. For dyslipidaemia, prevalence decreased during the pandemic 0.82 (95% CI 0.69 to 0.98); awareness did not change. For diabetes, prevalence did not change but awareness increased 5.76 (95% CI 1.23 to 27.04). No differences were found before and during the pandemic regarding treatment and control for all CVD risk factors. Relative to high SES, a decrease in hypertension awareness among middle SES categories was observed during the pandemic (OR and 95% CI 1.11 (0.73 to 1.69) before and 0.45 (95% CI 0.23 to 0.85) during, p for interaction<0.05), while no other changes were found.ConclusionPrevalence and management of CVD risk factors changed little during the pandemic. The SES gap did not increase except for hypertension awareness.
Impact of SeaQuest data on PDF fits at large x
Authors: Alekhin S. , Garzelli M. V. , Kulagin S. , Moch S.-O. 
Published: September 2023

AbstractWe evaluate the impact of recent SeaQuest (FNAL-E906 experiment) data on dimuon production in proton-deuteron and proton-proton collisions on parton distribution functions (PDFs). We find these data in a good agreement with the QCD predictions based on PDFs fitted to the Tevatron and LHC data on forward production of W and Z bosons. As a basis for this study we use the ABMP16 PDF fits and show that they turn out to be compatible with the SeaQuest data, and that these data have constraining power, allowing to reduce the uncertainties on the isospin asymmetry of the light-sea-quark distribution at large longitudinal momentum fraction x. We discuss the nuclear corrections needed to describe the deuteron and show that they affect the theoretical description of the proton-deuteron Drell–Yan cross section at the level of $$\mathcal {O}(0.5{-}1)$$

O
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0.5
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%. We also comment on the compatibility of the SeaQuest results with other state-of-the-art PDF fits and show that these data are in clear disagreement with models proposing an SU(3)-flavor symmetric quark sea. Finally, we perform a comparison between the second Mellin moments of the light-quark PDFs and recent results from various lattice QCD computations, which demonstrates good compatibility, albeit limited by the uncertainties inherent in current lattice QCD simulations.
Proletarian Feedback: The Mirror of the Soviet Public Sphere
Authors: Fore Devin 
Published: September 2023

Abstract
One glaring problem that faced the Bolsheviks upon seizing power was the absence of their vaunted class subject. The party had led a successful revolution in the name of the industrial worker, but once the dust settled after the civil war, reality exposed the proclaimed “dictatorship of the proletariat” to be little more than an empty slogan for propagandists. The proletariat was a historico-philosophical no-show. Its truancy had a number of reasons, both factual and theoretical. First, while proletarians had always been something of a rarity in the largely agrarian economy of imperial Russia, the industrial working class became even scarcer after the civil war had decimated the manufacturing capacity of Russia and ruralized the country once again. When the Bolsheviks finally took control, Russia's industrial output had fallen to thirty percent of prewar levels. Historians have consequently described the Bolsheviks as a “superstructure in need of a base”2 and a “vanguard of a nonexistent class.”3 Add to this, second, the fact that the physiognomy of the working class was changing in the 1920s as the forces of production shifted away from the methods of heavy manufacture typical of the second industrial revolution toward newer, automated technologies that relied less on physical exertion than on the scientific knowledge of engineers and managers. At least until Stalin's spectacular revival of older, “classical” forms of industry at the end of the decade—a return that seemed to be motivated less by economic exigency than by retrograde iconography—blast furnaces and factory workbenches were being replaced by telematic machinery and bureaucratic control centers. Third, according to revolutionary theory, in the phase of the transition to communism the proletariat was not even a class, strictly speaking, but the social force that abolishes class identity as such in order to establish for the first time in world history the conditions for a truly universal subject.4 The revolutionary class is, necessarily, the last class. Party philosophers could provide no substantialist definition of this “free dynamei (power, force),” as Marx called the proletariat, since this non-class had no concrete features of its own but was instead understood as an energy that dissolved the existing socioeconomic order.5 Paradoxically, then, the very success of the revolution “causes the concept of the proletariat to ‘disappear.’”6
Lisette Model: Another Frankfurt School Photographer in New York
Authors: Yoon Hyewon 
Published: September 2023

Abstract
This essay examines the portrait work of the Austrian-American photographer Lisette Model, with a special focus on her representation of the American lumpenproletariat in the Reflections series, Model's first after coming to New York in 1938 as an Austrian-French Jewish émigré, and in her Bowery portrait series. Within the history of American postwar photography, Model stands as a salient figure, a pioneer who located and defined the issues, options, and contradictions of photography as an artistic practice in the “New York School of photography.” Model's rendering of her subjects as eccentric, fantastic, and spectacular in their expressions and emotions propelled the émigré photographer with meager experience into a central position in the making of mid-century American photography, both social-documentary and commercial. Moving beyond the localized context of postwar American photography in which Model's work has been largely investigated, this essay argues for an understanding of Model's New York portraits as being shaped and informed by the photographer's consideration of the crisis of history and the violence enacted by fascism in Europe, as well as the historical condition of exile. One of the essay's claims is that Model revitalized a kind of pleasurable violence, one that enacts a sense of excessive bodily dynamism, often to the point of self-destruction, on the bodies of the American lumpenproletariat at leisure, in order both to come to terms with the role of the lumpenproletariat as the central subject of fascist politics and aesthetics in the Old World and to put pressure on the conditions of the mass subject and mass politics in the New World.
Effects of food matrix on the prebiotic efficacy of inulin-type fructans: a randomised trial
Authors: Jackson P.P.J. , Wijeyesekera A. , Theis S. , Van Harsselaar J. , Rastall R.A. 
Published: September 2023

Abstract
Recently there is much debate in the scientific community over the impact of the food matrix on prebiotic efficacy of inulin-type fructans. Previous studies suggest that prebiotic selectivity of inulin-type fructans towards bifidobacteria is unaffected by the food matrix. Due to differences in study design, definitive conclusions cannot be drawn from these findings with any degree of certainty. In this randomised trial, we aimed to determine the effects that different food matrices had on the prebiotic efficacy of inulin-type fructans following a standardised 10-day, 4-arm, parallel, randomised protocol with inulin either in pure form or incorporated into shortbread biscuits, milk chocolate or a rice drink. Similar increases in Bifidobacterium counts were documented across all four interventions using both fluorescence in situ hybridisation (pure inulin: +0.63; shortbread: +0.59; milk chocolate: +0.65 and rice drink: +0.71 (log10 cells/g wet faeces) and 16S rRNA sequencing quantitative microbiome profiling data (pure inulin: +1.21 × 109; shortbread: +1.47 × 109; milk chocolate: +8.59 × 108 and rice drink: +1.04 × 109 (cells/g wet faeces) (all ). From these results, we can confirm that irrespective of the food matrix, the selectivity of inulin-type fructans towards Bifidobacterium is unaffected, yet the compositional make-up of the food matrix may have implications regarding wider changes in the microbiota.
Revision of the genus Xizangiana Sherwood, Li & Zhang, 2022, with descriptions of five new species (Araneae: Gnaphosidae)
Authors: LIU BO , WANG LUYU , ZHANG FENG 
Published: September 2023

The genus Xizangiana Sherwood, Li & Zhang, 2022 is revised. Two known species and five new species from China are described and illustrated: Xizangiana linzhiensis (Hu, 2001), X. rigaze (Song, Zhu & Zhang, 2004), X. benae Liu & Zhang, sp. n. (♂♀), X. longlin Liu & Zhang, sp. n. (♂♀), X. namchabarwa Liu & Zhang, sp. n. (♂♀), X. shenxian Liu & Zhang, sp. n. (♂♀) and X. xiangbi Liu & Zhang, sp. n. (♂♀). Two new combinations from India, Xizangiana pawani (Gajbe, 1993) comb. n. (ex. Urozelotes Mello-Leitão, 1938) and X. sedula (Simon, 1897) comb. n. (ex. Poecilochroa Westring, 1874), are proposed. The subfamily placement of Xizangiana is discussed and the records of all the species is mapped.
Investigating a Derecho in a Future Warmer Climate
Authors: Lasher-Trapp Sonia , Orendorf Sophie A. , Trapp Robert J. 
Published: September 2023

Abstract
Derechos are extensive swaths of damaging winds produced by some long-lived, widespread mesoscale convective systems. Little research has been conducted concerning how derecho mechanisms might change in a future, warmer climate. In this study, the pseudo–global warming method is utilized to evaluate how the 10 August 2020 midwestern U.S. derecho, the costliest thunderstorm event in U.S. history to date, might differ if it instead occurred in a warmer climate at the end of this century. The 10 August derecho event is first simulated in its observed environment, and then resimulated in environments altered according to projections from different climate models using a high-emissions climate change scenario. Results suggest that near the end of this century, a similar derecho event may not necessarily have more intense winds but could possibly impact a geographical area 50% to 100% larger. The physical chain of events leading to this greater geographical impact result from the derecho winds beginning earlier in the storm lifetime, due to increased precipitation combined with decreased relative humidity right above the ground, and derecho winds extending northward due to a strengthening of the parent storm from increased instability there. All these factors enhance the area of evaporative cooling and thus the cold pool, which in turn extends the area covered by the rear-inflow jet within the storm, the likely main mechanism for most of the damaging winds at the ground in the historical event. More study of other cases is required to evaluate the generality of this result.
Local and Remote Causes of the Equatorial Pacific Cold Sea Surface Temperature Bias in the Kiel Climate Model
Authors: Zhang Yuming , Bayr Tobias , Latif Mojib , Song Zhaoyang , Park Wonsun , Reintges Annika 
Published: September 2023

Abstract
We investigate the origin of the equatorial Pacific cold sea surface temperature (SST) bias and its link to wind biases, local and remote, in the Kiel Climate Model (KCM). The cold bias is common in climate models participating in phases 5 and 6 of the Coupled Model Intercomparison Project. In the coupled experiments with the KCM, the interannually varying NCEP/CFSR wind stress is prescribed over four spatial domains: globally, over the equatorial Pacific (EP), the northern Pacific (NP), and the southern Pacific (SP). The corresponding EP SST bias is reduced by 100%, 52%, 12%, and 23%, respectively. Thus, the EP SST bias is mainly attributed to the local wind bias, with small but not negligible contributions from the extratropical regions. Erroneous ocean circulation driven by overly strong winds causes the cold SST bias, while the surface heat flux counteracts it. Extratropical Pacific SST biases contribute to the EP cold bias via the oceanic subtropical gyres, which is further enhanced by dynamical coupling in the equatorial region. The origin of the wind biases is examined by forcing the atmospheric component of the KCM in a stand-alone mode with observed SSTs and simulated SSTs from the coupled experiments. Wind biases over the EP, NP, and SP regions originate in the atmosphere model. The cold EP SST bias substantially enhances the wind biases over all three regions, while the NP and SP SST biases support local amplification of the wind bias. This study suggests that improving surface wind stress, at and off the equator, is a key to improve mean-state equatorial Pacific SST in climate models.
The impact of sales environment competitiveness on salespeople’s inclination towards unethical sales practices: The mediating role of self-control depletion and the moderating role of ethical leadership
Authors: Khan Salim , Shah Syed Jamal , Wang Chunlin , Ibrar Muhammad 
Published: September 2023

The study aims to explore the relationship between the sales environment competitiveness and the tendency towards unethical sales practices among salespeople who work in a demanding sales environment. Drawing on the conservation of resources (COR) theory, this study proposes that the perceived sales environment competition leads to self-control depletion, which, in turn, increases the likelihood of unfair sales practices. The study also suggests that ethical leadership can mitigate the aforementioned relationships. Data were collected through self-reported questionnaires from 379 salespeople working in the retail banking sector of Pakistan, using a time-lagged research design and structural equation modelling for analysis. Findings reveal that an increase in perceived sales environment competition leads to a higher probability of unethical sales practices due to self-control depletion. Ethical leadership plays a crucial role in constraining the influence of the perceived sales environment competition on self-control depletion. The study contributes to the sales ethics literature by investigating unethical sales practices from the perspective of sales environment competitiveness in contrast to the prevailing research that largely emphasizes on organizational or individual-level factors. Practically, this study suggests organizational decision makers and managers to consider the influence of a demanding sales environment and the psychological mechanisms that incline salespeople towards unethical sales practices; they should then design the appropriate mechanisms to control this behaviour. For instance, this can be achieved by incentivizing ethical sales practices or fostering a strong ethical culture within the organization to internalize sales ethics. Moreover, this study recommends sales manager to maintain high ethical standards to prevent the negative effect of a competitive sales environment on the ethical behaviour of salespeople. JEL Classification: M50
Clinical and economic impact of oncology-trained pharmacist integration in an ambulatory cancer clinic
Authors: Mull Ashley , Hawkins Courtney , Punke Alexandra , Parkey Shannon , Mallon Courtney 
Published: September 2023

Introduction Outpatient oncology practice is a growing area of opportunity for pharmacists to provide clinical services and evidence-based care. Methods This single-center, retrospective chart review analyzed the clinical and economic benefits of a board-certified oncology pharmacist after integration into the ambulatory oncology clinic setting. Primary outcomes were total cost avoidance for pharmacist interventions and impact on Centers for Medicare and Medicaid Services (CMS) OP-35 measures. Pharmacist interventions were characterized into distinct types which were then assigned a cost avoidance value. Cost avoidance was calculated per hour and then extrapolated to a yearly estimate based on a 40-h work week for one year for one full-time equivalent pharmacist. Data collection for the primary clinical outcome was performed by compiling provider-specific emergency department (ED) and inpatient admission rates for diagnoses specified in CMS OP-35 measures within 30 days after receiving outpatient chemotherapy. The rates for the data collection period were compared to the rates six months prior to pharmacist integration to assess pharmacist impact. Results In six months, 516 total interventions were made by the oncology pharmacist. The incidence of ED visits was 3.34% and 1.72% during the pre- and post-pharmacist intervention periods, respectively. The incidence of inpatient admissions was 2.43% and 0.34% pre- and post-pharmacist intervention, respectively. Total cost avoidance was estimated to be US$375,795 and when accounted for the median pharmacist salary at our institution, total cost savings was US$204,437. Conclusion The presence of an oncology pharmacist specialist in the ambulatory cancer clinic provided clinical and economic benefits to the cancer clinic.