bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upaya Peningkatan Kreativitas Anak Usia Dini Melalui Kegiatan Mewarnai Raudhatul Athfal (Ra) Al-Muhajirin Bitung
Authors: Kurniawan Irvan , Septogani Sonia 
Published: December 2022

Jurnal ini bertujuan untuk mengetahui: 1) Upaya peningkatan kreativitas anak usia dini melalui kegiatan mewarnai di Raudhatul Athfal (RA) Al-Muhajirin Bitung; 2) Kendala yang dihadapi dalam peningkatan kreativitas anak usia dini melalui kegiatan mewarnai di Raudhatul Athfal (RA) Al-Muhajirin Bitung; 3) Solusi menghadapi kendala dalam meningkatkan kreativitas anak usia dini melalui kegiatan mewarnai di Raudhatul Athfal (RA) Al-Muhajirin Bitung. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan penelitian lapangan (field research).
Hasil yang diperoleh dari penelitian ini, bahwa 1) Upaya peningkatan kreativitas anak didik melalui kegiatan mewarnai di Raudhatul Athfal (RA) al-Muhajirin Bitung telah berjalan dengan baik. Dengan langkah-langkah berikut: a) guru memperkenalkan warna terlebih dahulu kepada anak didik; b) mengajak anak didiknya untuk mulai mewarnai gambar sederhana; c) setelah anak didik sudah merasa senang kemudian di ajak mewarnai hewan atau tumbuhan; d) guru mulai menerapkan aturan dalam mewarnai gambar dengan rapi tidak boleh keluar dari garis dan menyesuaikan warna dengan bentuk aslinya; e) lalu guru mengajak anak didiknya dalam kelas untuk mengenal campuran warna yang dapat membentuk warna lainnya; f) kemudian guru melakukan penilaian dengan membandingkan hasil dari kegiatan mewarnai sebelumnya dengan hasil yang sekarang; 2)
Terdapat dua kendala dalam peningkatan kreativitas anak usia dini melalui kegiatan mewarnai di Raudhatul Athfal (RA) al-Muhajirin Bitung, yaitu: a) faktor internal disebabkan karena usia masih terlampau muda yakni 4,5 tahun; dan 2) faktor eksternal, adanya pola asuh dari orangtua yang terlalu ketat mengawasi kegiatan anak, sehingga anak terhambat dalam pengembangan kreativitasnya; 3) Solusi menghadapi kendala dalam peningkatan kreativitas anak usia dini melalui kegiatan mewarnai di Raudhatul Athfal (RA) al-Muhajirin Bitung, yaitu: 1) melatih pola pikir anak; 2) ciptakan pembelajaran yang menyenangkan; 3) Buat anak agar mau belajar mengamati; 4) Biarkan mereka melakukan sendiri; 5) berikan apresiasi; 6) jangan memarahinya, dan 7) ajaklah mereka berkreasi sambil bermain.
PKM PENYULUHAN PENCATATAN KEUANGAN BAGI PELAKU USAHA MIKRO KECIL PADA KELURAHAN MEKARSARI DEPOK
Authors: Shahreza Dhona , Lindiawatie Lindiawatie , Ria Anita 
Published: December 2022

Pelaku usaha mikro kecil memiliki kelemahan dalam pencatatan transaksi keuangannya. Kondisi ini pula yang terjadi pada sebagian besar pelaku usaha mikro kecil di kelurahan Mekarsari, Cimanggis, Depok. Sistem administrasi dan pencatatan keuangan yang diterapkan masih sangat sederhana. Bahkan, tidak jarang masih ada pelaku usaha mikro kecil yang belum dapat memisahkan pos keuangan usaha dengan keluarga (pribadinya). Ini menyebabkan mereka tidak mengetahui secara akuntansi laba yang sudah mereka dapat. Mengetahui permasalahan itu, dibutuhkan penyuluhan bagi mereka supaya terbuka cara pandang dalam mencatat, mengadministrasikan dan membuat laporan keuangan yang benar. Tujuan abdimas ini adalah untuk memberikan penyuluhan dan simulasi cara pengelolaan administrasi keuangan secara terstruktur, terorganisir dan sistematis saat menyusun pendapatan dan pengeluaran, sehingga tidak tercampur antara keuangan pribadi dan usaha. Hasilnya adalah respon positif peserta dengan terbukanya cara pandang pelaku usaha mikro kecil tentang pembuatan laporan keuangan yang tepat. Namun, karena pengetahuan yang diperoleh hanya singkat, maka bekal yang diperoleh saat abdimas belum cukup, Oleh karenanya perlu ditindaklanjuti dengan pendampingan dan perlunya pedoman ringkas tata cara pembuatan laporan keuangan usaha mikro kecil yang bermaksud memudahkan mereka saat Menyusun laporan keuangan
Antibacterial, antioxidant, and phytochemical analysis of Piper longum fruit extracts against multi-drug resistant non-typhoidal Salmonella strains in vitro
Authors: Rawat Pallavi , Chauhan Vidya , Chaudhary Juhi , Singh Chhaya , Chauhan Neha 
Published: December 2022

Most bacteria are becoming resistant to almost all of the currently recommended drugs, leading to difficulty in their treatment. The present study focused on evaluating the therapeutic potential of Piper longum fruit extracts in terms of bactericidal, antioxidant and phytochemical evaluation by conducting antibacterial sensitivity tests against four multidrug-resistant Salmonella strains (Salmonella enterica subsp. arizonae, Salmonella Newport, Salmonella enterica ser. Typhi, and Salmonella enterica ser. Paratyphi) obtained from the Institute of Microbial Technology (IMTECH), Chandigarh. The Agar Well Diffusion method and the Minimum Inhibitory concentration (MIC) methods were performed to implement the anti-sensitivity test of crude extracts of the plant. The present study showed that the MIC of the P. longum was between 0.25-0.0625mg/ml, which was lowest in the aqueous extract at 0.5mg/100µl, and the highest in the methanol extract (1mg/100µl). The Minimum Bactericidal Concentration (MBC) was lowest in aqueous (0.5mg/100µl) and highest in methanol plant extract (1mg/100µl). The methanol extract had the maximum antibacterial potency, whereas the aqueous extract had the lowest. The antioxidant capacity of the plant extracts was determined using a DPPH assay. Methanol plant extract revealed the highest antioxidant power (81.92%) and the lowest was found in the aqueous extract (62.84%). The GC-MS approach identified active bioingredients, important botanicals including caryophyllene, eicosane, and piperazine (potent antibacterial agent) as naphthyridine (having antimicrobial, anticancer, and anti-inflammatory activities), among others. The unique aspect of the study was the effectiveness of P. longum against Salmonella strains that are resistant to multiple antibiotics. This suggests that P. longum can be a great source of novel antibacterial compound for the development of herbal formulations.
A review on regulatory control of chromium stress in plants
Authors: Yadav Priyanka , Sharma Asha , Singh Sandeep 
Published: December 2022

Chromium (Cr) is a non-biodegradable heavy metal that persists long in aquatic and terrestrial ecosystems and enters the food chain. It is cytotoxic even at low concentrations and reduces the yield of plants. Plants also have cellular mechanisms to manage the accumulation of metal ions inside the cell to diminish the possible injury from non-essential metal ions. This paper reviews current information on plant response to Cr, a key environmental pollutant. The harmful effects together with absorption, transfer, and aggregation of Cr are discussed. The roles of the cell wall, plasma membrane, and plant microbes as the primary hindrances for Cr ingression into the cell, along with sequestration and compartmentalization process, have also been discussed. Cr-generated oxidative injury is also regarded as the main deliberated effect of Cr toxicity. It interferes with NADPH oxidases (plasma membrane) and the electron transport chains, which develop electron leakage. Some genes related to Cr stress in plants get expressed, and suppression produces protective effects by activating the signal transduction pathways. The expression of genes like BnaCnng69940D and BnaC08g49360D is increased, which is involved in protein kinase activity, signal transduction, and oxidoreductase activity. The increased mRNA levels of Cr stress response proteins, including HSP90-1 and MT-1, have been reported in the Brassica napus plant. The stressed environment around the plants may stimulate the biosynthesis of phytochelatins and metal-binding proteins, which have a protective role in plant’s growth and development.
Assessment of seedling traits of rice landraces under different saline conditions
Authors: Shafeeqa T. , Ravichandran V. , Senthil A. , Arul L. , Radhamani S. 
Published: December 2022

Salinity is one of the major abiotic stresses affecting rice growth and yield worldwide. In rice, the most critical stages which affect salinity at a greater level are germination, vegetative and reproductive stages.It is very important to know the genotypic variation among landraces under saline conditions at the seed germination stage to reduce the harmful effect of salinity. The present study conducted on Petri plate was mainly for assessing germination, relative water content and seedling parameters of eleven rice landraces with check landrace Pokali under three different salt concentrations (75mM, 125mM and 150mM). Two-way ANOVA gave the variations among the genotypes, treatments and their interactions. The present study showed that Mundan, Odiyan, Muttadan, Kallimadiyan and Vellimuthu had less percentage reduction in growth parameters at the germination stage. Odiyan and Mundan showed less percentage reduction in fresh weight (36.09%) and shoot length (25.61%) respectively, in relative water content (10.70% and 16.07%, respectively) at higher concentrations of salinity (150mM) compared to control. Pokali, Chembakam and Odiyan showed good germination parameters under three different saline treatments compared to other genotypes. Biplot analysis showed 65.4% variation between the treatments, whereas the variation between the genotypes was around 13.3%. Screening of landraces for salinity tolerance at the seed germination stage is the most reliable method to identify the salt tolerant line at the early seedling stage. The present study can be used for further screening programme at the vegetative stage for the identification of potential salt tolerant lines to improve breeding and gene introgression studies.
Effect of copper, nickel and lead on callus growth dynamics of Solanum lycopersicum
Authors: Kumari Anjana , Nagpal Avinash Kaur , Katnoria Jatinder Kaur 
Published: December 2022

Solanum lycopersicum cv. (Punjab Kesar Cherry) (Tomato) belonging to family Solanaceae has been priced for the presence of lycopene, low sugar content and curative properties. However, the productivity of tomatoes has been observed to be low due to both biotic as well as abiotic stress. Considering the toxicity of copper (Cu), lead (Pb) and nickel (Ni) as environmental contamination and the economic importance of S. lycopersicum, the present study was undertaken to investigate the effects of these heavy metals on various growth parameters of callus cultures and plantlet regeneration. Callus induced through nodal segments was inoculated on Murashige and Skoog medium containing different concentrations (0 µM, 50 µM, 100 µM, 200 µM, 300 µM, 400 µM and 500 µM) of copper, lead and nickel. Decrease in different growth parameters was observed as 91.66-16.66 %, 76.38-11.11 %, 81.94-13.88 % for percent callus survival, 90.90-25 %, 72.72-37.50 %, 79.66-20 % for percent callus multiplication, 79.54-0 %, 82.75-33 %, 63.8-50 % for percent root regeneration and 73.33-33 %, 72.50-33 %, 79.6- 20 % for percent shoot generation with increasing concentrations of Cu, Pb and Ni, respectively. Decrease in the average fresh and dry weight of callus was observed for all the metals. The order of toxicity was observed as Pb > Ni > Cu at the highest concentrations used for treating S. lycopersicum. The present study revealed that all three metals induced stress in the studied plant and need attention to developing methods to mitigate the consequences of metal toxicity in crop plants.
Novel method to manage weeds in the rainfed groundnut (var. VRI 8 and TMV 14) using nano encapsulated herbicide formulations
Authors: Swetha S. , Chinnamuthu C. R. , Arthanari P. Murali , Marimuthu S. , Senthil A. 
Published: December 2022

The groundnut crop harbours heavy weed infestation due to its small stature and slow growing nature. The current weed management practices of hand weeding and use of commercial herbicides are unsuitable because of high labour cost and inadequate moisture availability to activate herbicides. In order to release the herbicide in a smart way, this experiment aimed to study the efficacy of encapsulated herbicides . Field experiments were conducted during Kharif 2021 and late Rabi 2022 under rainfed conditions in randomised block design with three replications. The treatments consisted of sulfentrazone, oxyfluorfen, diclosulam and metolachlor in both commercial and encapsulated form using two doses, hand weeding at 20 and 40 DAS, weed free plot and weedy check. Minimum weed density (28.33 and 17.30 No./m2 at 90 DAS during Kharif and late Rabi respectively) and weed dry weight (65.33 and 61.25 g/m2 at 90 DAS during Kharif and late Rabi respectively) were observed in hand weeding at 20 and 40 DAS (T19) followed by diclosulam @ 25 g ha-1 with encapsulation (T7). Maximum weed density and weed dry weight was observed in metolachlor @ 1 kg/ha with encapsulation (T8). Higher productivity was observed in hand weeding at 20 and 40 DAS (T19) (1802 kg ha-1 and 1753 kg ha-1 pod yield during Kharif and late Rabi respectively) and higher profitability was obtained in diclosulam @ 25 g ha-1 with encapsulation (T7) (1.80 and 2.01 B:C ratio during (Kharif and late Rabi respectively). Nano-encapsulated herbicides can thus significantly improve weed control in rainfed groundnut.
Preparation and in-vitro Evaluation of Secnidazole as Periodontal In-situ Gel for Treatment of Periodontal Disease
Authors: Raheema Dheyaa A , Kassab Hanan Jalal 
Published: December 2022

This study aims to develop a thermosensitive mucoadhesive periodontal in situ gel of secnidazole for local release of drug for treatment of periodontitis, in order to increase the drug residence time and to increase patient compliance while lowering the side effects of the drug.
Cold method was used to prepare 30 formulas of secnidazole periodontal in situ gel, using different concentrations of thermosensitive polymers (poloxamer407 alone or in combination with poloxamer 188) and methyl cellulose (MC ) or hydroxypropyl methylcellulose (HPMC K4M )in different concentrations used as mucoadhesive polymer and the resultant formulations were subjected to several tests such as gelation temperature GT, appearance and pH value. The formulas with the most appropriate GT were subjected to in-vitro drug release. Three formulas were chosen with appropriate release, F6 (15% P407, 1% MC), F29 (18%P407,3% P188, 0.8% HPMC) and F30 (18%P407,3% P188, 1% HPMC). These formulas were subjected to mucoadhesive force, viscosity, drug content, spreadability, gelation time and Fourier Transform Infrared (FTIR) compatibility studies.
The results indicates that formula F29 and F30 have best gelation temperatures (33°C, 32°C) gel strength (1.5h,2h) mucoadhesive force of (17.1, 23.4 dyne/cm2 ) and in-vitro drug release (98.2%, 100%) respectively during 3.5h and gelation, time about 10 seconds for both formulas and FTIR spectrum study show absence of important interaction between secnidazole and the polymers used.
The Effects of a Psycholinguistic Approach to Multisensory Instruction on Psycholinguistic Abilities of Children with Learning Disabilities
Authors: Saleh Al Rasheed Loul 
Published: December 2022

Purpose. The purpose was to investigate the effect of a psycholinguistic training to improve expressive language among children with ASD.
Methods. Data were collected from children during the academic year 2021-2022. The participants were 20 children with ASD, aged 7 to 10 years, who were enrolled in a school for children with ID. All children attended the same semester inside the school. Parent consent forms were sent home by the principal and school psychologist to the parents of the prospective participants to inform them about the study and ask them to give permission for their children to participate. Demographic information was obtained from school records and as reported by families. Children were divided randomly into two groups: one experimental (n=10) and other was the control group (n=10). These children were matched as a group with cases on the basis of age, IQ, social class and general level of language ability. A 24 items, six-dimensional Questionnaire was developed in particular for this study. The intention was to identify expressive language skills for children with ASD. The six dimensions are: speaking and questioning skills in correct language (4 items), the ability to verbally express things, needs, and desires (4 items), the skill of pronouncing and imitating words, letters and sounds (4 items), repetition and arranging skill (4 items), the ability to verbally express feelings (4 items), the ability to respond to the speech and questions of others.
Results. Results indicated increased speaking and questioning skills in correct language, the ability to verbally express things, needs, and desires, the skill of pronouncing and imitating words, letters and sounds, repetition and arranging skill, the ability to verbally express feelings and the ability to respond to the speech and questions of others.
Conclusions. Overall, results from this study contribute to the growing literature on the effect of a psycholinguistic training to improve expressive language among children with ASD. The present study lends empirical support to the notion that expressive language of children with ASD can be improved through a psycholinguistic training.
Use of adhesive cranial bone flap fixation without hardware to improve mechanical strength, resist cerebrospinal fluid leakage, and maintain anatomical alignment: a laboratory study
Authors: Smith Timothy R. , Foley Kevin T. , Boruah Sourabh , Slotkin Jonathan R. , Woodard Eric , Lazor John B. , Cavaleri Christy , Brown Michael C. , McDonough Brittany , Hess Brian , Van Citters Douglas W. 
Published: December 2022

OBJECTIVE
Titanium plates and screws (TPS) are the current standard of care for fixation of cranial bone flaps. These materials have been used for decades but have known potential complications, including flap migration, bone resorption/incomplete osseous union, hardware protrusion, cosmetic deformity, wound infection/dehiscence, and cerebrospinal fluid (CSF) leakage. This study evaluated the efficacy of a novel mineral-organic bone adhesive (Tetranite) for cranial bone flap fixation.

METHODS
Craniotomy bone flaps created in human cadaveric skulls were tested under quasistatic and impact loading in the following conditions: 1) uncut skull; 2) bone flaps fixated with TPS alone; and 3) bone flaps fixated with bone adhesive alone. All fixative surgical procedures were performed by a group of 16 neurosurgeons in a simulated surgical environment. The position of adhesive-fixated cranial bone flaps was measured using computed tomography and compared with their original native location. The resistance of adhesive-fixated cranial bone flaps to simulated CSF leakage was also evaluated. Because there was a gap around the circumference of the TPS-fixated specimens that was visible to the naked eye, pressurized CSF leak testing was not attempted on them.

RESULTS
Adhesive-fixated bone flaps showed significantly stiffer and stronger quasistatic responses than TPS-fixated specimens. The strength and stiffness of the adhesive-fixated specimens were not significantly different from those of the uncut native skulls. Total and plastic deflections under 6-J impact were significantly less for adhesive-fixed bone flaps than TPS. There were no significant differences in any subthreshold impact metrics between the adhesive-fixed and native specimens at both 6-J and 12-J impact levels, with 1 exception. Plastic deflection at 6-J impact was significantly less in adhesive-fixated bone flaps than in native specimens. The energy to failure of the adhesive-fixated specimens was not significantly different from that of the native specimens. Time since fixation (20 minutes vs 10 days) did not significantly affect the impact failure properties of the adhesive-fixated specimens. Of the 16 adhesive-fixated craniotomy specimens tested, 14 did not leak at pressures as high as 40 mm Hg.

CONCLUSIONS
The neurosurgeons in this study had no prior exposure or experience with the bone adhesive. Despite this, improved resistance to CSF egress, superior mechanical properties, and better cosmetic outcomes were demonstrated with bone adhesive compared with TPS.
Efficacy and safety of stereotactic radiosurgery versus endovascular treatment for symptomatic cavernous sinus dural arteriovenous fistula without ophthalmological emergency: a single-center 10-year experience
Authors: Kim Min Jeoung , Hong Seung Woo , Kim Dong Joon , Kim Byung Moon , Kim Yong Bae , Chang Won Seok , Park Keun Young 
Published: December 2022

OBJECTIVE
Stereotactic radiosurgery (SRS) is emerging as a treatment option for cavernous sinus dural arteriovenous fistula (CS dAVF); it is less invasive and has a lower complication rate than conventional surgeries. However, little is known regarding the advantages and limitations of SRS compared to those of endovascular treatment (EVT). The aim of this study was to compare the efficacy and safety between EVT and SRS for treatment of CS dAVF.

METHODS
Between January 2011 and April 2021, a total of 86 consecutive patients diagnosed with CS dAVF were treated with EVT or SRS. Among them, 8 patients with ophthalmological emergency and 8 without follow-up data at ≥ 12 months were excluded. During the same period, no neurological deficit due to intracranial hemorrhage or seizure was noted in any of the patients. Ultimately, 70 patients (EVT 33, SRS 37) were included in this study. Demographic characteristics, initial clinical presentations, clinical outcomes, and radiological findings were retrospectively reviewed and compared. Procedure-related complications were also assessed after the treatments.

RESULTS
The patients’ baseline characteristics (except conjunctival symptoms) and angiographic features of CS dAVF were not significantly different between the EVT and SRS groups. Conjunctival symptoms were more frequently noted in the EVT than in the SRS group (69.7% vs 40.5%, p = 0.015). After EVT, initial complete obliteration was achieved in 20 cases (60.6%). Complete obliteration was achieved at 6 months in 86.4% of cases with EVT and in 77.8% of those treated with SRS (p = 0.507), and at 12 months in 86.4% cases with EVT and in 94.4% of those treated with SRS (p = 0.357). Worsening of symptoms developed at 1 month in 24.2% of cases with EVT and in 5.4% of those treated with SRS (p = 0.038); at 6 months in 22.6% of cases with EVT and in 10.8% of those treated with SRS; and at 12 months in 30.0% of cases with EVT and in 13.5% of those treated with SRS (p = 0.099). The angioarchitecture of CS dAVF did not affect angiographic obliteration after SRS. Procedure-related morbidity and mortality occurred more frequently in the EVT than in the SRS group (27.3% vs 8.1%, p = 0.034).

CONCLUSIONS
Both EVT and SRS were effective for the treatment of CS dAVF without ophthalmological emergency. However, procedure-related morbidity and mortality was less frequent in SRS than in EVT, and consequently SRS may be more advantageous in terms of safety.