bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing Pediatric Drugs' Safety and Effectiveness: A Systematic Review and Meta-Analysis
Authors: Saharan Dr. Priyanka , Srinivasa Rao Varri 
Published: February 2025

The public health issue of patient safety and effectiveness is becoming more widely acknowledged. Most medications do not come in dosage forms that are appropriate for giving to children. Most therapies used to prevent or treat illnesses in infants and children are medications that were created and researched for use in adults. They might not work the best and/or are administered in unappetizing dosage forms, which eventually results in low patient adherence and insufficient medication exposure. Among the most frequent medical mistakes are those involving medications, and research indicates that children are especially susceptible. Any stage of the drug procedure is susceptible to errors. Medication errors pose significant risks to pediatric patients, leading to adverse drug events, hospitalizations, and even fatalities. The outpatient pharmacy plays a crucial role in ensuring accurate dispensing and administration of medications. However, despite existing safety measures, medication errors continue to occur. The comprehensive review of the safety and effectiveness of pediatric drugs is the goal of this paper. In order to offer evidence-based guidance for clinical practice, this systematic review and meta-analysis attempts to assess the safety and effectiveness of frequently prescribed pediatric drugs.
Expression of mIRNA-142-3P in Peripheral Blood From Active and Latent Pulmonary Tuberculosis
Authors: Andi Sitti Nur Afiah , Uleng Bahrun , Muhammad Nasrum Massi , Irawaty Djaharuddin 
Published: February 2025

This study aimed to asses miRNA-142-3p expression of active and latent pulmonary tuberculosis. 33 people with active Tuberculosis (TB), 36 household contacts who tested positive for IFN-released assay (IGRA), and 39 healthy controls made up this case-control study. Latent pulmonary tuberculosis infection in household contacts was identified using an IGRA based on an enzyme-linked immunosorbent test. miRNA-142-3p expression was measured by quantitative real-time PCR. Data analysis used analysed of variance and receiver operating characteristic (ROC) curves. The results showed that miRNA-142-3p expression differed significantly between active TB, latent TB and healthy participans (control p=<0.001). ROC curve analysis showed that miRNA-142-3p expression had 66.7% sensitivity and 61.5% specificity with an area under the ROC curve (AUC) of 0.725 ( 95% confidence interval (CI): 0.606 – 0.844) in active TB. The miRNA-142-3p ROC curve had 63.9% sensitivity and 51.3% specificity with an area under the ROC curve (AUC) of 0.603 (95% confidence interval (CI): 0.475 - 0.730) for laten TB. miRNA-142-3p expression was increased in patients with active pulmonary TB. Therefore, miRNA-142-3p represents a potential biomarker active pulmonary TB but not to latent TB.
Efficacy of Deep Friction Massage Cyriax Techniques in Patello Femoral Pain Syndrome or Anterior Knee Pain in Geriatric Patients
Authors: Bisht Rakhi , Sharma Rahul , Sharma Rahul , Lakhera Sakshi , Patra Anirban , Lal Sohan , Parmar Nitin , Raj Bist Binod 
Published: February 2025

Patella-femoral pain syndrome (PFPS) is common cause of anterior knee pain the purpose of this article is to review knee anatomy and the literature regarding potential risk factors associated with patella- femoral pain syndrome and pre-rehabilitationstrategies.39to40% of patients still experiencing symptoms after a year of followup, recurrence is common.When symptoms continue after six months of conservative therapy and when clear malalignments are found, surgical intervention should be taken into consideration A comprehensive review of knee anatomy will present the relationships of arterial collateralization, innervations, and soft tissue alignment to the possible multifactoral mechanism involved in PFPS, while attempting to advocate future use of different treatments aimed at non-soft tissue causes of PFPS.
Exploring Acapella Therapy for Enhancing Pulmonary Parameters in Bronchiectasis patients: A Scoping Review
Authors: Pinki Pinki , Aditi Aditi , Nagpal Lakshya 
Published: February 2025

Objective: To investigate the impact of acapella therapy on pulmonary function, sputum volume, and health-related quality of life (HRQOL) in individuals with bronchiectasis, supported by evidence-based research.
Methods: This systematic review was conducted in alignment with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The databases searched included PubMed, PEDro, and the Cochrane Library (Controlled Trials and Systematic Reviews). After screening, relevant data were extracted, charted, and presented through figures, tables, and narrative synthesis. Only randomized controlled trials examining the effects of acapella or PEP devices in individuals with bronchiectasis were included.
Results: This analysis, which included 255 patients from four studies, revealed diverse findings regarding respiratory interventions. The first study found no significant difference in sputum wet weight between bubble-PEP and ACBT during the intervention; however, bubble-PEP demonstrated greater sputum clearance 60 minutes post-session. The second study showed that patients in the OPEP group experienced fewer and later-onset exacerbations compared to those in the CCPT group, along with improvements in health-related quality of life, comfort, and well-being. In the third study, both ELTGOL and Positive Expiratory Pressure techniques led to significant improvements in pulmonary function, with ELTGOL producing superior outcomes. Lastly, the fourth study reported no significant baseline differences in FVC, FEV1, or FEV1/FVC between groups A and B, but both groups showed considerable post-treatment improvements, emphasizing the effectiveness of these interventions in improving respiratory function.
Conclusion: These studies highlight that all interventions contribute positively to pulmonary function and quality of life, with techniques like ELTGOL and OPEP showing distinct advantages in areas such as reducing exacerbation frequency and improving long-term sputum clearance. Further research is needed to explore these variations, assess long-term effects, and customize interventions to meet the specific needs of patients with chronic respiratory conditions.
Gastric Volvulus in A Neonate With Omphalocele Treated With Scarification: A Case Report
Authors: Puspitasari Eva , Setiawan Ariandi 
Published: February 2025

Background: Gastric volvulus is a rare but potentially life-threatening condition. Evaluating Borchardt's triad in neonates can be challenging and may be absent. Despite its rarity; if left untreated, it can result in a high mortality rate, necessitating immediate diagnosis and management.
Case Presentation: A newborn was diagnosed with an omphalocele. The patient was treated with scarification. During treatment, the patient consistently exhibited obstructive symptoms. A midline incision was made above the omphalocele ring, followed by encircling the ring to open the abdominal cavity. During surgery, grade 2-3 adhesions were identified on the greater curvature of the stomach, leading to organo-axial volvulus. Adhesiolysis was performed. The gastric volvulus occurred due to adhesions between the stomach and liver, which were connected to the omphalocele sac, leading to organo-axial volvulus. At the two-months follow-up after surgery, the patient has no obstructive symptoms and the surgical wound was in good condition.
Conclusion: Gastric volvulus in neonates can result from abnormal bands and adhesions on the stomach leading to axial twisting and volvulus. Gastric volvulus requires early diagnosis and immediate management, as delays can lead to complications that increase morbidity and mortality.
Influence of Shallow and Deep-Aqua Aerobic Exercises on Maximal Oxygen Consumption Parameter Tested to College Men Students
Authors: Mohana Krishnan R. 
Published: February 2025

The current study set out to investigate the effects of aerobic exercises in shallow and deep water on the maximal oxygen consumption metric given to male college students. The objective of this research was accomplished in 2023–2024 when 45 college male students were chosen from North Chennai Swimming Academy in Chennai, Tamil Nadu. The age range of the subject is 17–23. Three equal groups of 15 subjects each were formed from the chosen subjects: the two experimental groups and a control group of undergraduates. For six weeks, the testing groups I and II engaged in deep aqua aerobic exercise (DAAG) and shallow aqua aerobic activity (SAAG), correspondingly. Throughout the trial, there was no exercise performed by the control group. The study's primary outcome was the maximal oxygen consumption measured using Cooper's formulas and, in turn, the Cooper 12-Minute Run/Walk Assessment. Before the six-week exercise session, a pre-test was administered, and right after, a post-test was measured. The analysis of covariance (ANCOVA) was utilized to determine the F ratio after the data gathered from the three groups was statistically examined for significance. The matched mean differences are ascertained by applying the Scheffe's test as a post-hoc test. The significance level will be set at the 0.05 level of confidence for every instance.
The Ameliorative Role of Oregano aqueous extraction (Origanum vulgare) on Liver Enzymes, Hormones (Testosterone and Cortisol) and Antioxidant Parameters in Male Rats Exposed to Aluminum Oxide Nanoparticles
Authors: Jabbar Almiahy Ashwaq , Jaber Hasan Iman 
Published: February 2025

Aluminum oxide nanoparticles Al₂O₃-NPs are extensively applied in medicine, manufacturing and consumer products. However, their bioaccumulation- particularly in the liver - induces oxidative stress, and hepatocellular damage. Chronic exposure to Al₂O₃- NPs disrupts liver function, deteriorates testosterone synthesis and reduces antioxidant defenses. Oregano or (Origanum vulgare) , a Mediterranean herb exhibits potent antioxidant properties, anti-inflammatory and hepatoprotective features. Regardless evidence of its therapeutic interest, limited studies inspect its role in counteracting nanoparticle-induced toxicity. Forty adult male Norwegian rats are divided into four equal groups and treated orally as follows: G1: control (normal saline), G2: Al₂O₃ NPs (50 mg/kg/day), G3: Oregano aqueous extract (200 mg/kg/day) and G4: Combination the same doses of Al₂O₃ NPs + oregano extract . The experiment lasted for 30 days, animals were sacrificed after 24 hours from the last administration , blood samples were collected to study the biochemical parameters as well as the livers and testes were removed and preserved for histopathological examination. Results : levels of liver enzymes (ALT,AST and ALP), hormones (testosterone and cortisol) and antioxidant biomarkers (SOD), (GSH), (CAT) and (MDA) were improved by oregano aqueous extract in the combination group when compared to the same parameters in Al₂O₃-NPs group as well as its ameliorative role in the histopathological sections .In conclusion Oregano extract mitigates Al₂O₃- NP toxicity through antioxidant and anti-inflammatory mechanisms, supporting its use in nanoparticle-related toxicity management .
Understanding Psychosocial and Socio-Cultural Processes Towards Fitness Doping: A Meta-Synthesis Study
Authors: Ömercioğlu Mine , Erman Alparslan 
Published: February 2025

Research indicates that the unregulated and excessive utilisation of Performance Enhancing Substances (PES) is also prevalent in physical exercise contexts beyond the domain of competitive sports, thereby raising concerns about the potential for doping to permeate broader society. The objective of this study is to gain insight into and elucidate the psycho-social and socio-cultural context surrounding the utilisation of Performance Enhancing Substances (PES) in physical exercise settings, within the framework of existing literature. In this context, nine qualitative articles were selected based on predetermined exclusion and inclusion criteria from the Web of Science, Scopus and SportDiscus databases. Subsequently, the articles were subjected to qualitative data analysis using the Nvivo research statistics programme, and the findings were synthesised. The following themes were identified from the articles examined: “Demographic change”,	“gendered resistance”, “hegemonic masculinity”, “appearance”, “encouragement”, “exit point”, “performance”, “self-enhancement”, “social approval”, “the body of man”, “homosexuality”, “limitations” and “transformation”. It is recommended that the use of all substances and methods that may have negative effects on human and public health should be reduced or prevented in these environments with appropriate measures.
Implementasi Sistem Informasi Berbasis Web untuk Pengelolaan Kedisiplinan Santri di Pondok Pesantren
Authors: Muhammad Muhammad , Sucipto Sucipto , Muzaki Muhammad Najibulloh , Andriyanto Sidhiq 
Published: February 2025

Latar Belakang: Pendidikan di pondok pesantren berperan penting dalam membentuk karakter dan kedisiplinan santri, Namun, pengelolaan data kedisiplinan yang masih dilakukan secara manual di Pondok Pesantren Mamba’ul Hisan Isyhar menyebabkan sejumlah kendala, seperti ketidakakuratan, ketidakefisienan, dan risiko kehilangan data. Tujuan Penelitian : untuk mengembangkan sistem informasi manajemen kedisiplinan berbasis teknologi. Metode: Penelitian ini menerapkan metode pengembangan sistem Waterfall yang mencakup analisis, desain, pengkodean, pengujian, dan pemeliharaan, didukung oleh observasi, wawancara, dan studi literatur. Pengujian dilakukan menggunakan metode Blackbox Testing untuk mengevaluasi fungsionalitas sistem. Hasil: Sistem pengelolaan data kedisiplinan untuk pencatatan pelanggaran dan prestasi santri serta meningkatkan transparansi informasi. Kesimpulan: Sistem informasi manajemen kedisiplinan berbasis teknologi ini memenuhi tujuan penelitian, manajemen kedisiplinan di pesantren, dan dapat menjadi model bagi institusi pendidikan lain dalam pengelolaan kedisiplinan berbasis digital.
«Мы верим гению Петра Великого»: петровский миф российских «ревнителей Севера» 60—70х годов XIX века
Authors: Агапов М. 
Published: February 2025

В статье предлагается реконструкция петровского мифа как центрального пункта исторического, политического и экономического воображения группы российских предпринимателей и общественных деятелей 60—70-х годов XIX века, известных как «ревнители Севера». Раскрывается связь между сконструированным ими образом Петра I и их политическим языком и системой аргументации. Делается вывод, что обращение к деяниям Петра I было для «ревнителей Севера» одним из способов риторической инструментализации своих аргументов. В условиях, когда институциональные основы общественной жизни в Российской империи только формировались, дефицит концептуальных понятий и риторических приемов восполнялся обращением к истории, из которой заимствовался язык для обсуждения актуальных общественно-политических проблем.
The article proposes a reconstruction of the Peter’s myth as a central point of the historical, political and economic imagination of a group of Russian entrepreneurs and public figures of the 60s—70s of the 19th century, known as the “zealots of the North”. The connection between the image of Peter I constructed by them and their political language and system of argumentation is revealed. It is concluded that the appeal to the deeds of Peter I was for the “zealots of the North” one of the ways of rhetorically instrumentalizing their arguments. In the conditions when the institutional foundations of public life in the Russian Empire were just being formed, the lack of conceptual concepts and rhetorical devices was made up by turning to history, from which language was borrowed for discussing current socio-political problems.
CRESCIMENTO ECONÔMICO: UM COMPARATIVO ENTRE DUAS CIDADES DO NORDESTE DO BRASIL
Authors: Ramos Débora de Morais , Lira Ana Claudia de Queiroz 
Published: February 2025

O presente trabalho analisa o crescimento econômico das cidades de Pedras de Fogo/PB e Itambé/PE, pertencentes a região Nordeste do Brasil, no período de 2010 a 2020. O objetivo geral consiste em identificar fatores determinantes, diferenças, semelhanças e tendências nas trajetórias econômicas dessas duas localidades que formam uma ligação interestadual. Para alcançar tal propósito, a partir de um levantamento de dados secundários de fontes oficiais, foi feita uma análise comparativa sobre a dinâmica de crescimento econômico das cidades, consideradas as seguintes dimensões: produção industrial, agrícola e de serviços, emprego, renda per capita, fatores locais, políticas públicas, aspectos de infraestrutura e da história socioeconômica que moldaram o destino dessas cidades. Os resultados alcançados neste recorte de pesquisa evidenciam que, apesar dos avanços econômicos, ambos os municípios enfrentam desafios sociais e econômicos, como a necessidade de investimentos em infraestrutura e serviços públicos. A disparidade dos recursos destinados aos programas do Plano Plurianual (PPA) entre Itambé e Pedras de Fogo evidencia diferenças nas realidades econômicas e demográficas, destacando a importância de políticas públicas adequadas para promover um crescimento mais equitativo e sustentável. Sob enfoque desta pesquisa, as dimensões produtivas, socioeconômicas e das receitas públicas, compuseram um viés importante para compreender a expansão e o dinamismo econômico em uma determinada região além de, consideradas as devidas limitações teóricas e metodológicas da pesquisa, servir como base para o delineamento de políticas e estratégias mais eficazes para impulsionar o crescimento econômico.
Development of Wireless Agricultural Cultivator Machine
Authors:   Department of Mechanical Engineering, Sri Sairam Engineering College, Chennai, Kumar V2 Ranjith 
Published: February 2025

Integrating wireless electronics technology with agricultural equipment, a new wireless agriculture cultivator is a revolutionary product in agriculture. This unique system autonomously performs necessary functions in the development procedure, including tillage and weeding, using a combination of wireless channels, detectors, and independent management methods. Precision agriculture is another excellent example of LD because a cultivator can work autonomously and efficiently in the field with the aid of GPS and artificial intelligence, completing tasks without human interaction It forms a wireless link to allow real-time data transfer from the machine to the cultivator, giving a centralized view of the entire process. By creating this feedback loop of communication, remote monitoring, control, and modifications are all possible, resulting in resource efficiency and higher yields. This innovation brings a new revolution in farming practices by Eco-Friendly, Energy-Efficient, Soundless Operation Made available in all ranges of agriculture, with the ultimate aim to reduce farm working efforts, increase output levels and reduce environmental issues. With fairly a bit of potential to rework contemporary agriculture, your adaptiveness in addition to that’s thought-about an important component within the evolution of contemporary agriculture

Key Words: wireless cultivator, low fuel usage(battery)
Caractérisation stylistique de la métaphore adjectivale dans La Semaine Africaine
Authors: Nguiene Bilongo Brèche Pachel 
Published: February 2025

Ce présent article examine la caractérisation stylistique de la métaphore adjectivale dans l’expression journalistique. Il s’agit d’analyser trois contextes fonctionnels des adjectifs qui créent une particularité du style dans les écrits des journalistes : l’art de critiquer, de représenter et de caractériser les événements et les faits de l’actualité. Pour aborder des adjectifs, nous avons recouru à un corpus recueilli dans la Semaine Africaine. Ainsi, l’objectif fixé est de montrer que la métaphore adjectivale traduit une motivation descriptive et persuasive et qu’elle engendre des effets stylistiques dans le langage journalistique. Dans l’application de la pragmatique, nos résultats ont montré que la métaphore adjectivale offre aux journalistes un style expressif, esthétique, sincère et photographique et qu’elle devient une pratique de l’argumentation dans la presse écrite congolaise.
Digitalisation of Public Service Delivery, and Innovation in Government Operations in Central Asia and the Caucasus
Authors: Omarova Tolkyn , Sharipova Diana 
Published: February 2025

This article presents the progress countries of Central Asia and the Caucasus have made in the areas of innovation and digitalisation. It utilises the findings of a needs-assessment study, recently completed, on the state of digitalisation in the countries of Central Asia and the Caucasus. Such findings explicitly reveal where these countries stand across nine dimensions, considered critical for the advancement of innovation in government operations and of digitalisation of public services and their provision through differentiated channels of delivery. The article highlights where these countries stand nowadays, as well as what they ought to do in order to advance further.
Key words: civil service, public services, digitalisation, innovation
Emotional Regulation and Subjective Well-Being in Adolescents: A Systematic Review
Authors: Martínez-Líbano Jonathan , Axel Kosch Serey  , Guillermo Barahona-Fuentes  
Published: February 2025

Introduction: Emotional regulation and its relationship with subjective well-being are relevant phenomena to study, especially during adolescence, a critical period marked by significant changes in mental health and social development. These antecedents underscore the importance of studying how emotional regulation can act as a protective factor for adolescents' subjective well-being. Purpose: The purpose of this systematic review was to investigate the impact of emotional regulation on adolescents' subjective well-being. Methodology: The search was conducted following the PRISMA methodology in the Web of Science, Scopus, PubMed, and Scielo databases, and the methodological quality was also assessed using the Newcastle-Ottawa Scale (NOS). Results: A total of 16 studies met the inclusion criteria, highlighting that adaptive emotional regulation strategies, particularly cognitive reappraisal and acceptance, are consistently associated with higher levels of life satisfaction, happiness, and self-esteem. Moreover, these strategies act as protective factors against depression, anxiety, and emotional distress. Studies employing longitudinal designs suggest that emotional regulation fosters resilience and improves adolescents' long-term well-being. Conversely, maladaptive strategies such as rumination and suppression were linked to lower subjective well-being and increased psychological distress. Conclusions: The findings underscore the critical role of emotional regulation in fostering adolescent well-being. Specifically, interventions that promote cognitive reappraisal and acceptance may enhance psychological resilience and overall life satisfaction. Future research should explore the long-term effects of emotional regulation training and its integration into educational and clinical settings to support adolescent mental health