bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Nexus Between COVID-19 Factors and Air Pollution
Authors: Parvin Rehana 
Published: April 2023

Background and Objective: There have been significant effects of the current coronavirus-19 (COVID-19) infection outbreak on many facets of everyday life, particularly the environment. Despite the fact that a number of studies have already been published on the topic, an analysis of those studies’ findings on COVID-19’s effects on environmental pollution is still lacking. The goal of the research is to look into greenhouse gas emissions and air pollution in Bangladesh when COVID-19 is under rigorous lockdown. The specific drivers of the asymmetric relationship between air pollution and COVID-19 are being investigated. Methods: The nonlinear relationship between carbon dioxide ([Formula: see text]) emissions, fine particulate matter [Formula: see text] and COVID-19, as well as its precise components, are also being investigated. To examine the asymmetric link between COVID-19 factors on [Formula: see text] emissions and [Formula: see text] we employed the nonlinear autoregressive distributed lag (NARDL) model. Daily positive cases and daily confirmed death by COVID-19 are considered the factors of COVID-19, with lockdown as a dummy variable. Results: The bound test confirmed the existence of long-run and short-run relationships between variables. Bangladesh’s strict lockdown, enforced in reaction to a surge of COVID-19 cases, reduced air pollution and dangerous gas emissions, mainly [Formula: see text] according to the dynamic multipliers graph.
Improved Outcomes in Operative Management of Concomitant Distal Radius and Scaphoid Fractures
Authors: Verlinsky Luke , Ulmer Clinton , Rose Alec , Brady Christina , Rose Ryan 
Published: April 2023

Background: This study aims to investigate the characteristics of concomitant distal radius and scaphoid fractures and determine outcome differences of operative and nonoperative management. Methods: A retrospective search of a level-1 trauma center’s database over a 15-year period (2007-2022) for concomitant distal radius and scaphoid fractures in adult patients was completed. In all, 31 cases were reviewed for mechanism of injury, method of fracture management, distal radius fracture AO Foundation/Orthopaedic Trauma Association classification, scaphoid fracture classification, time to radiographic scaphoid union, time to motion, and other demographics. A multivariate statistical analysis was completed comparing outcomes in operative versus conservative management of the scaphoid fracture in these patients. Outcomes were defined as time to radiographic union and time to motion. Results: In all, 22 cases of operative fixation of the scaphoid and 9 cases of nonoperative management of the scaphoid were reviewed. One case of nonunion was identified in the operative group. Operative management of scaphoid fractures resulted in a statistically significant reduction in time to motion (2-week reduction) and time to radiographic union (8-week reduction). Conclusions: This study demonstrates that operative management of scaphoid fractures in the setting of a concomitant distal radius fracture reduces the time to radiographic union and time to clinical motion. This suggests that operative management is ideal in patients who are good candidates for surgery and desire earlier return of motion. However, conservative management should be considered, as nonoperative care showed no statistical difference regarding union rates of scaphoid or distal radius fractures.
Observing Senior and More Experienced Colleagues in Action: A Useful Tool for Early Career Teaching Staff at Higher Education Institutions
Authors: Fabiyi Samson D. 
Published: April 2023

Highlights Teaching staff at higher education institutions need exposure to different teaching approaches and technologies to bring excellence to teaching and learning. This can be actualized through observation of senior and more experienced colleagues in action. This paper, therefore, examines how teaching staff at the early career stage can benefit from teaching observation, and also presents the author's self-reflection on teaching observation.
Outcome of medial open wedge high tibial osteotomy and conversion knee arthroplasty in a local joint replacement centre
Authors: Brian Leung Hok W , Bruce Tang Yan H 
Published: April 2023

Background The primary purpose of this study is to evaluate the long-term survivorship of medial open wedge high tibial osteotomy. The secondary purpose is to review the clinical outcome and surgical challenges during conversion knee arthroplasty. Methodology The patients with medial open wedge high tibial osteotomy performed from 1995 to 2019 were reviewed. The survivorship, surgical particulars and clinical outcomes of the conversion arthroplasty were reviewed. Results There were 61 medial open wedge high tibial osteotomy performed from 1995 to 2019. The overall 10-year survival rate of medial open wedge high tibial osteotomy is 83.7%. In total, 22 medial open wedge high tibial osteotomy required conversion arthroplasty and none of them required revision in the study period. The patients who required conversion arthroplasty had higher mean posterior tibial slope than those who did not require it (14.5° vs 11.6°; p = 0.047). In total, 52.3% required quadriceps snip for exposure, 14.3% need a tibial stemmed component and 9.5% need a constrained total knee replacement. There was statistically significant improvement in Knee Society knee score, functional score, and range of motion after the conversion arthroplasty. Conclusion The 10-year survival rate of medial open wedge high tibial osteotomy is satisfactory. The patients who required conversion arthroplasty had higher mean posterior tibial slope. In conversion cases, with careful pre-operative planning, most of them can be converted to conventional total knee replacement. The range of movement and functional scores significantly improved after conversion arthroplasty. Also, patellar baja or not does not predict the need for quadriceps snip during conversion arthroplasty.
Level of Knowledge on Kangaroo Mother Care and Its Associated Factors Among Postnatal Mothers With Preterm Babies in Central Tanzania: Hospital-Based Cross-Sectional Study
Authors: Chamhene Naomi , Moshi Fabiola Vincent 
Published: April 2023

Introduction Kangaroo mother care (KMC) has been proven to reduce preterm babies’ deaths by 40%. The study aimed at assessing the prevalence and predictors of knowledge about KMC among postnatal mothers of preterm babies in the Central zone, Tanzania. Objective To assess the level of knowledge about KMC and its associated factors. Methods It was an analytical cross-sectional study involving 363 mothers of preterm babies from the Central zone. All mothers admitted during data collection and who met the inclusion criteria were enrolled until the sample size was attained. A structured questionnaire was used for data collection. Data were analyzed using SPSS v23. Descriptive statistics were used to describe the study variable while inferential statistics (univariate and multivariate analyses) were used to determine the predictors of knowledge. Results Only 138(38%) postnatal mothers had adequate knowledge about KMC. Factors associated with knowledge on KMC were the age of the mother (those aged ≥30 years were almost four times more likely to have adequate knowledge compared to those aged <20 years [ P  =  .044]), level of education of the mother (women who had secondary education and above were six times more likely to have adequate knowledge on KMC compared with those with no formal education [ P < .001) and the family type of a postnatal mother living in (those living in a nuclear families were 48% less likely to have adequate knowledge if compared with those living in extended families [ P  =  .012]). Conclusion Less than half of the interviewed postdelivery women had adequate knowledge of KMC. Postdelivery women who were more likely to have adequate knowledge about KMC were those aged more than 30 years, with a higher level of education, and living in extended families. We recommend a deliberate effort on improving postnatal mothers’ knowledge of KMC, one of the strategies being initiating care of preterm babies in the antenatal package to prepare these mothers.
Ontogenesis of functional platelet subpopulations from preterm and term neonates to adulthood: The PLINIUS study
Authors: Weiss Lukas J. , Drayss Maria , Mott Kristina , Beck Sarah , Unsin David , Just Bastian , Speer Christian P. , Härtel Christoph , Andres Oliver , Schulze Harald 
Published: April 2023

AbstractErythrocytes undergo a well-defined switch from fetal to postnatal circulation, which is mainly reflected by the stage-specific expression of hemoglobin chains. Perinatal alterations in thrombopoiesis are poorly understood. We assessed the ontogenesis of platelet phenotype and function from early prematurity to adulthood. We recruited 64 subjects comprising 7 extremely preterm (27-31 weeks gestational age), 25 moderately preterm (32-36 weeks), 10 term neonates, 8 infants (&lt;2 years), 5 children (2-13 years), and 9 adults (&gt;13 years). Blood was withdrawn at up to 3 different time points in neonates (t1: 0-2, t2: 3-7, and t3: 8-14 days after birth). We found that the expression levels of the major surface receptors for fibrinogen, collagen, vWF, fibronectin, and laminin were reduced but correlated with decreased platelet size, indicating a normal surface density. Although CD62P and CD63 surface exposure upon stimulation with TRAP-6, ADP, or U46619 was unaltered or only slightly reduced in neonates, GPIIb/IIIa inside-out and outside-in activation was blunted but showed a continuous increase until adulthood, correlating with the expression of the GPIIb/IIIa regulating tetraspanin CD151. Platelet subpopulation analysis using automated clustering revealed that neonates presented with a CD63+/PAC-1– pattern, followed by a continuous increase in CD63+/PAC-1+ platelets until adulthood. Our findings revealed that the number of platelet-monocyte and platelet-neutrophil aggregates, but not platelet-lymphocyte aggregates, is increased in neonates and that neonatal aggregate formation depends in part on CD62P activation. Our PLatelets In Neonatal Infants Study (PLINIUS) provides several lines of evidence that the platelet phenotype and function evolve continuously from neonates to adulthood.
The relationship between four types of premature ejaculation patients and the quality of residential environment
Authors: Liu Xi , Zhu Tianle , Gao Pan , Gao Jingjing , Gao Rui , Jiang Hui , Zhang Xiansheng 
Published: April 2023

Abstract
Background
We investigated the association between premature ejaculation (PE) and the quality of residential environment from a new perspective to explore the influencing factors of PE, especially in four PE subtypes. We selected 499 adult males to participate in this study from September 2021 to September 2022. The satisfaction of residential environment was assessed by the Perceived Residential Environment Quality Indicators (PREQIs) scale, the control ability over ejaculation was assessed using the premature ejaculation diagnostic tool (PEDT), and their depression was assessed using the self-rating depression scale (SDS).

Results
The Architectural and Town-planning Spaces (ATS), Green Spaces (GS), and Commercial Services (CS) of PE patients (N = 346) were compared with those of control group (N = 153), showed a significant difference (p < .05), for PE patients, the score of ATS was 44.30 ± 12.38, the score of GS was 18.60 ± 6.24, and the score of CS was 20.82 ± 8.20; for control group, which were 40.46 ± 16.21, 20.69 ± 5.71 and 22.90 ± 7.03 respectively. After age was taken into account, ATS had a positive correlation with PEDT score (r = 0.76), whereas GS and CS had a negative correlation (r = -0.87, -0.90); ATS had a positive correlation with SDS (r = 0.96), whereas GS and CS had a negative correlation (r = -0.74, -0.81).

Conclusions
We discovered that PE patients more likely resided in high-density areas with little green space and subpar commercial services, which might have an adverse effect on their mental health. This study offered a new viewpoint about the influence of residential environment on PE.
lifex-fiber: an open tool for myofibers generation in cardiac computational models
Authors: Africa Pasquale Claudio , Piersanti Roberto , Fedele Marco , Dede’ Luca , Quarteroni Alfio 
Published: April 2023

Abstract
Background
Modeling the whole cardiac function involves the solution of several complex multi-physics and multi-scale models that are highly computationally demanding, which call for simpler yet accurate, high-performance computational tools. Despite the efforts made by several research groups, no software for whole-heart fully-coupled cardiac simulations in the scientific community has reached full maturity yet.

Results
In this work we present $$\texttt {life}^{\texttt {x}}$$

life
x

-fiber, an innovative tool for the generation of myocardial fibers based on Laplace-Dirichlet Rule-Based Methods, which are the essential building blocks for modeling the electrophysiological, mechanical and electromechanical cardiac function, from single-chamber to whole-heart simulations. $$\texttt {life}^{\texttt {x}}$$

life
x

-fiber is the first publicly released module for cardiac simulations based on $$\texttt {life}^{\texttt {x}}$$

life
x

, an open-source, high-performance Finite Element solver for multi-physics, multi-scale and multi-domain problems developed in the framework of the iHEART project, which aims at making in silico experiments easily reproducible and accessible to a wide community of users, including those with a background in medicine or bio-engineering.

Conclusions
The tool presented in this document is intended to provide the scientific community with a computational tool that incorporates general state of the art models and solvers for simulating the cardiac function within a high-performance framework that exposes a user- and developer-friendly interface. This report comes with an extensive technical and mathematical documentation to welcome new users to the core structure of $$\texttt {life}^{\texttt {x}}$$

life
x

-fiber and to provide them with a possible approach to include the generated cardiac fibers into more sophisticated computational pipelines. In the near future, more modules will be successively published either as pre-compiled binaries for systems or as open source software.
nRCFV: a new, dataset-size-independent metric to quantify compositional heterogeneity in nucleotide and amino acid datasets
Authors: Fleming James F. , Struck Torsten H. 
Published: April 2023

Abstract
Motivation
Compositional heterogeneity—when the proportions of nucleotides and amino acids are not broadly similar across the dataset—is a cause of a great number of phylogenetic artefacts. Whilst a variety of methods can identify it post-hoc, few metrics exist to quantify compositional heterogeneity prior to the computationally intensive task of phylogenetic tree reconstruction. Here we assess the efficacy of one such existing, widely used, metric: Relative Composition Frequency Variability (RCFV), using both real and simulated data.

Results
Our results show that RCFV can be biased by sequence length, the number of taxa, and the number of possible character states within the dataset. However, we also find that missing data does not appear to have an appreciable effect on RCFV. We discuss the theory behind this, the consequences of this for the future of the usage of the RCFV value and propose a new metric, nRCFV, which accounts for these biases. Alongside this, we present a new software that calculates both RCFV and nRCFV, called nRCFV_Reader.

Availability and implementation
nRCFV has been implemented in RCFV_Reader, available at: https://github.com/JFFleming/RCFV_Reader. Both our simulation and real data are available at Datadryad: https://doi.org/10.5061/dryad.wpzgmsbpn.
Genomic and transcriptomic analysis of sacred fig (Ficus religiosa)
Authors: Ashalatha K. L. , Arunkumar Kallare P , Gowda Malali 
Published: April 2023

Abstract
Background
Peepal/Bodhi tree (Ficus religiosa L.) is an important, long-lived keystone ecological species. Communities on the Indian subcontinent have extensively employed the plant in Ayurveda, traditional medicine, and spiritual practices. The Peepal tree is often thought to produce oxygen both during the day and at night by Indian folks. The goal of our research was to produce molecular resources using whole-genome and transcriptome sequencing techniques.

Results
The complete genome of the Peepal tree was sequenced using two next-generation sequencers Illumina HiSeq1000 and MGISEQ-2000. We assembled the draft genome of 406 Mb, using a hybrid assembly workflow. The genome annotation resulted in 35,093 protein-coding genes; 53% of its genome consists of repetitive sequences. To understand the physiological pathways in leaf tissues, we analyzed photosynthetically distinct conditions: bright sunny days and nights. The RNA-seq analysis supported the expression of 26,479 unigenes. The leaf transcriptomic analysis of the diurnal and nocturnal periods revealed the expression of the significant number of genes involved in the carbon-fixation pathway.

Conclusions
This study presents a draft hybrid genome assembly for F. religiosa and its functional annotated genes. The genomic and transcriptomic data-derived pathways have been analyzed for future studies on the Peepal tree.
Promoting the application of Pinus thunbergii Parl. to enhance the growth and survival rates of post-germination somatic plantlets
Authors: Sun Tingyu , Wang Yanli , Wu Xiaoqin , Ye Jianren , Cheng Fang 
Published: April 2023

Abstract
Objective
There is a growing need for nematode resistant Pinaceae species plantlets to cope with the global scale degradation of coniferous forests, due to the prevalence of pine wilt disease. One of the bottlenecks that limits the commercialization of Pinaceae species plantlets is regeneration following their transfer from controlled sterile environments to the field while maintaining high survival rates.

Methods
The growth factors of somatic plantlets (SPs), such as sucrose, media, culture substrate, brassinolide and spectrum were investigated to promote the application of somatic nematode-resistant P. thunbergii plants in afforestation.

Results
The 1/2 WPM liquid medium, culture substrate (perlite and vermiculite =1:1), and carbohydrate (20 g/L sucrose) were effective in stimulating the growth of rooted SPs. While for unrooted SPs, 1 ug/L of brassinolide enhanced plantlet growth and rooting. And blue light (B) significantly promoted the longitudinal growth of shoots, while red light (R) was beneficial for root growth during the laboratory domestication stage. High quality SPs were obtained at a R/B ratio of 8:2. Following this acclimatization protocol, the P. thunbergii SPs could be directly transplanted to the field with a higher survival rate (85.20 %) in a forcing house.

Conclusion
this acclimatization protocol extremely improved the survival rate of P. thunbergii SPs. Moreover, this work will contribute to enhancing the possibilities for somatic plant afforestation with Pinus species.
Integrative analysis of HASMCs gene expression profile revealed the role of thrombin in the pathogenesis of atherosclerosis
Authors: Zhang Yichen , Sun Lin , Wang Xingsheng , Zhou Qingbo 
Published: April 2023

AbstractWe explored the effect of thrombin on human aortic smooth muscle cells (HASMCs) and further analyzed its role in the pathogenesis of atherosclerosis (AS). Thrombin-induced differentially expressed genes (DEGs) in HASMCs were identified by analyzing expression profiles from the GEO. Subsequently, enrichment analysis, GSEA, PPI network, and gene-microRNAs networks were interrogated to identify hub genes and associated pathways. Enrichment analysis results indicated that thrombin causes HASMCs to secrete various pro-inflammatory cytokines and chemokines, exacerbating local inflammatory response in AS. Moreover, we identified 9 HUB genes in the PPI network, which are closely related to the inflammatory response and the promotion of the cell cycle. Additionally, we found that thrombin inhibits lipid metabolism and autophagy of HASMCs, potentially contributing to smooth muscle-derived foam cell formation. Our study deepens a mechanistic understanding of the effect of thrombin on HASMCs and provides new insight into treating AS.
Tumor size as a significant prognostic factor in T1 gastric cancer: a Surveillance, Epidemiology, and End Results (SEER) database analysis
Authors: Xiao Xueyan , Gao Beibei , Pang Suya , Wang Zeyu , Jiang Weiwei , Wang Weijun , Lin Rong 
Published: April 2023

Abstract
Background
It has previously been observed that the prognostic value of tumor size varied according to different stages patients enrolled in gastric cancer. We aimed to investigate the influence of T stage on the prognostic and predicting value of tumor size.

Material and methods
A total of 13,585 patients with stage I–III gastric cancer were selected from the Surveillance, Epidemiology, and End Results Program (SEER) database. Univariate and multivariate cox regression analysis stratified by T stage were performed. C-index and time-dependent receiver operating characteristic curve (ROC) curve were applied to assess discrimination ability of tumor size and other factors. Nomograms were constructed to further assess the performance of tumor size in a specific model. Calibration ability, discrimination ability, reclassification ability and clinical benefits were executed to judge the performance of models.

Results
Stratified analyses according to T stage illustrated that with the increase of T stage, the effect of tumor size on overall survival (OS) and cancer-specific survival (CSS) significantly decreased. Moreover, tumor size showed superior discrimination ability in T1 gastric cancer, outperformed other prognostic factors in predicting both CSS (C-index: 0.666, AUC: 0.687) and OS (C-index: 0.635, AUC: 0.660). The cox regression model included tumor size showed better performance than the model excluded tumor size in every aspect.

Conclusion
T stage had a negative impact on the predicting value of tumor size. Tumor size showed significant prognostic value in T1 gastric cancer, which may be effective in clinical practice.