bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement of superoxide dismutase: clinical usefulness for patients with anti-neutrophil cytoplasmic antibody-associated vasculitis
Authors: Zhang Zhihuan , Huang Wenhan , Ren Feifeng , Luo Lei , Zhou Jun , Tang Lin 
Published: June 2023

Abstract
Objective
To investigate the clinical usefulness of serum superoxide dismutase (SOD) measurement in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

Methods
In this single-center retrospective study, demographic data, serum SOD levels, erythrocyte sedimentation rate (ESR), C reactive protein (CRP), the Birmingham Vasculitis Activity Score (BVAS), ANCA, organ involvement, and outcomes were analyzed for 152 AAV patients hospitalized in the Second Affiliated Hospital of Chongqing Medical University. Meanwhile, the serum SOD levels of 150 healthy people were collected as the control group.

Results
Compared to the healthy control group, serum SOD levels of the AAV group were significantly lower (P < 0.001). SOD levels of AAV patients were negatively correlated to ESR, CRP, and BVAS (ESR rho = − 0.367, P < 0.001; CRP rho = − 0.590, P < 0.001; BVAS rho = − 0.488, P < 0.001). SOD levels for the MPO-ANCA group were significantly lower than the PR3-ANCA group (P = 0.045). SOD levels for the pulmonary involvement group and the renal involvement group were significantly lower than those for the non-pulmonary involvement group and the non-renal involvement group (P = 0.006; P < 0.001, respectively). SOD levels in the death group were significantly lower than the survival group (P = 0.001).

Conclusions
In AAV patients, low SOD levels might indicate disease associated oxidative stress. SOD levels in AAV patients were decreased with inflammation, suggesting that SOD levels could potentially be a surrogate marker for disease activity. SOD levels in AAV patients were closely related to ANCA serology, pulmonary involvement, and renal involvement, with low SOD levels an important indicator of a poor prognosis for AAV patients.
Maternal- and child-related risk factors for autism during the perinatal period
Authors: Mahboub Samira , Al-Suhaibani Sara , Ellatif Hala Abd , Elkholi Safaa M. 
Published: June 2023

Abstract
Background
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder commonly prevalent in children worldwide including KSA. It causes disability in social interaction, communication, and restrictive and repetitive behaviors. Detecting risk factors for ASD could help initiate screening and risk prevention approaches. Herein, this study aimed to detect several maternal and neonatal risk factors for ASD in KSA.

Results
Ninety-four cases and 282 control completed an online survey tool. The survey items were close-ended questions. Participants were asked about maternal-related risk factors for autism during perinatal period. The logistic regression model revealed having a child diagnosed with autism with two predictors: factors related to the mother and factors related to the baby during perinatal period. The whole model was sig (p < 0.0001). The factors related to the baby have more impact on developing autism than maternal factors (OR is 3 vs 2.3, respectively, p < 0.01 for both).

Conclusion
The findings of this study will be beneficial for subsequent nationwide screenings and educational programs. The study brought to light the potential for identifying children in need of early intervention.
Assessing the accuracy of empirical decline curve techniques for forecasting production in unconventional reservoirs: a case study of Haynesville, Marcellus, and Marcellus Upper Shale
Authors: Coutry Shams , Tantawy Mahmoud , Fadel Sayed 
Published: June 2023

AbstractDecline curve analysis (DCA) is a widely used method to estimate the production performance and ultimate recovery of conventional and unconventional reservoirs. Due to the unconventional nature of shale wells, traditional decline curve methods are not ideal for analyzing their production decline behavior. In response, different empirical methods have been developed and used which rely on different mathematical and statistical approaches and can result in varying forecasts.This study compares fourteen decline curve methods, along with the traditional Arps method, in terms of their ability to match production history, sensitivity to data size, effect of flow type, production forecast, and ultimate recovery estimation.The methods were tested on three wells from Haynesville Shale (Lorikeet Field), Marcellus Shale (Ostrich Field), and Marcellus-Upper Shale (Penguin Field) respectively. The study concludes that each method may be useful in different cases, and engineers should choose the method that best models their wells based on their specific characteristics and circumstances. Recommendations were also provided for an effective evaluation of uncertainty and application of DCA. The primary objective of this study is to improve the accuracy and reliability of DCA predictions for different reservoir types with different declining modes.
Characteristics of rabbit hapten-specific and germline-based BCR repertoires following repeated immunization
Authors: Li Yuan , Kong Yihui , Yu Xuezhi , Yu Wenbo , Wen Kai , Shen Jianzhong , Wang Zhanhui 
Published: June 2023

Abstract
The rabbit is well known for producing diverse antibodies against various antigens including small molecules such as drugs and toxins, due to a robust immune response. Elucidating how hapten repeated immunization shapes the rabbit B cell receptor (BCR) repertoire is crucial to understanding rabbit immune response to small molecules and assisting rare antibody discovery/engineering. In this study, we enriched and sequenced chloramphenicol (CAP)-specific rabbit B cells following repeated immunization, and analyzed both CAP-specific repertoires combined with the structure and affinity features of V1S69/V1S37 germline-based BCRs. The length of rabbit complementarity-determining region 3 of heavy chain (CDRH3) increased after hapten immunization. Repeated immunization significantly reduced the diversity of CAP-specific rabbit BCR clonotypes, and changed the frequency of VDJ usage and the type of V(D)J recombination. The average number of mutations among VL is notably higher than that of VH genes in rabbits, however, they are both not changed along with repeated immunization. Moreover, repeated immunization resulted in an increase surface charge and a decrease in solvent accessible surface area, leading to improvement in the stability of the most abundant V1S69/V1S37 germline-based BCR, along with an affinity increase from an IC50 of 898.2 ng mL−1 at the 1st immunization to 4.16 ng mL−1 at the 6th immunization. The study provides a benchmark for rabbit repertoire-scale analyses and offers a method for antibody discovery of small molecules.
Distinguishing between ICD-11 complex post-traumatic stress disorder and borderline personality disorder: clinical guide and recommendations for future research
Authors: Karatzias Thanos , Bohus Martin , Shevlin Mark , Hyland Philip , Bisson Jonathan I. , Roberts Neil , Cloitre Marylène 
Published: June 2023

SummaryAlthough complex post-traumatic stress disorder and borderline personality disorder are distinct disorders, there is confusion in clinical practice regarding the similarities between the diagnostic profiles of these conditions. We summarise the differences in the diagnostic criteria that are clinically informative and we illustrate these with case studies to enable diagnostic accuracy in clinical practice.
Safety, Tolerability, and Antitumor Activity of Zipalertinib Among Patients With Non–Small-Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Exon 20 Insertions
Authors: Piotrowska Zofia , Tan Daniel Shao-Weng , Smit Egbert F. , Spira Alexander I. , Soo Ross A. , Nguyen Danny , Lee Victor Ho-Fun , Yang James Chih-Hsin , Velcheti Vamsidhar , Wrangle John M. , Socinski Mark A. , Koczywas Marianna , Janik John E. , Jones Jeffrey , Yu Helena Alexandra 
Published: June 2023

PURPOSE

Although several agents targeting epidermal growth factor receptor (
EGFR
) exon 20 insertions (ex20ins) have recently been approved by the US Food and Drug Administration, toxicities related to the inhibition of wild-type (WT)
EGFR
are common with these agents and affect overall tolerability. Zipalertinib (CLN-081, TAS6417) is an oral EGFR tyrosine kinase inhibitor (TKI) with a novel pyrrolopyrimidine scaffold leading to enhanced selectivity for
EGFR
ex20ins-mutant versus WT
EGFR
with potent inhibition of cell growth in
EGFR
ex20ins-positive cell lines.

METHODS

This phase 1/2a study of zipalertinib enrolled patients with recurrent or metastatic
EGFR
ex20ins-mutant non–small-cell lung cancer (NSCLC) previously treated with platinum-based chemotherapy.

RESULTS
Seventy-three patients were treated with zipalertinib at dose levels including 30, 45, 65, 100, and 150 mg orally twice a day. Patients were predominantly female (56%), had a median age of 64 years, and were heavily pretreated (median previous systemic therapies 2, range 1-9). Thirty six percent of patients had received previous non-ex20ins EGFR TKIs and 3/73 (4.1%) patients received previous EGFR ex20ins TKIs. The most frequently reported treatment-related adverse events of any grade included rash (80%), paronychia (32%), diarrhea (30%), and fatigue (21%). No cases of grade 3 or higher drug-related rash or diarrhea were observed at 100 mg twice a day or below. Objective responses occurred across all zipalertinib dose levels tested, with confirmed partial response (PR) observed in 28/73 (38.4%) response-evaluable patients. Confirmed PRs were seen in 16/39 (41%) response-evaluable patients at the dose of 100 mg twice a day.

CONCLUSION

Zipalertinib has encouraging preliminary antitumor activity in heavily pretreated patients with
EGFR
ex20ins-mutant NSCLC, with an acceptable safety profile, including low frequency of high-grade diarrhea and rash.
Practices and Views of US Oncologists and Genetic Counselors Regarding Patient Recontact After Variant Reclassification: Results of a Nationwide Survey
Authors: Makhnoon Sukh , Davidson Elenita , Shirts Brian , Arun Banu , Shete Sanjay 
Published: June 2023

PURPOSE Over a 5-year or 10-year period, between 6% and 15% of germline cancer genetic variants undergo reclassification. Up-to-date interpretation can clarify a variant's clinical significance and guide patient management. As the frequency of reclassifications increase, the issue of whether, how, when, and which providers should recontact patients with information about reclassification becomes important. However, the field lacks research evidence and definitive guidance from professional organizations about how providers should recontact patients. We compared the perspectives of US oncologists and cancer genetic counselors (GCs) to describe their practices and views regarding recontact. MATERIALS AND METHODS We developed a survey using themes identified from semistructured interviews with oncologists and GCs and administered it in a national sample of oncologists and GCs between July and September 2022. RESULTS In total, 634 respondents completed the survey including 349 oncologists and 285 GCs. On frequency of recontacting patients with reclassified results, 40% of GCs reported recontacting often compared with 12.5% of oncologists. Neither group reported recording patient preference for recontact on electronic medical record (EMR). Both groups agreed that all reclassified variants, even those that do not affect clinical management, should be returned to patients. They also reported that recontact via EMR messages, mailed letters, and phone calls from GC assistants were more suitable for downgrades. By contrast, face-to-face meetings and phone calls were preferred for upgrades. Remarkably, oncologists were more likely to endorse face-to-face return of results and were more likely to endorse return through a nongenetics provider compared to GCs. CONCLUSION These data on current recontact practices and opinions provide a foundation for developing guidelines with explicit recommendations on patient recontact that can help maximize clinical effect while considering provider preferences for recontact within resource-constrained genomic practice settings.
Testosterone Replacement Therapy in Relation With Cardiovascular Disease in Cisgender Women and Transgender People
Authors: Lopez David S , Mulla Juwairia S , El Haddad Danielle , Tahashilder Md Ibrahim , Polychronopolou Efstathia , Baillargeon Jacques , Kuo Yong-Fang , Gilani Syed , Khalife Wissam I 
Published: June 2023

Abstract

Aims
This study aimed to investigate the association of testosterone replacement therapy (TTh) with risk of cardiovascular disease (CVD), and CVD-specific outcomes, in cisgender women and transgender population, and to determine whether this association varies by menopausal status.

Methods
In 25 796 cisgender women and 1580 transgender people (≥30 years old) who were enrolled in the Optum's deidentified Clinformatics Data Mart Database (2007-2021), we identified 6288 pre- and postmenopausal cisgender women and 262 transgender people diagnosed with incident composite of CVD (coronary artery disease [CAD], congestive heart failure, stroke, and myocardial infarction). Prediagnostic prescription of TTh was ascertained for this analysis. Multivariable adjusted Cox proportional hazards models were used to examine the independent association of TTh with incident CVD.

Results
We found a 24% increased risk of CVD (hazard ratio [HR] = 1.24; 95% CI, 1.15-1.34), 26% risk of CAD (HR = 1.26; 95% CI, 1.14-1.39), and a 29% risk of stroke (HR = 1.29; 95% CI, 1.14-1.45) after comparing cisgender women who used TTh with nonusers. Stratification by age group showed similar effects of TTh on CVD, CAD, and stroke. Among transgender people, TTh did not increase the risk of composite CVD, including by age stratification.

Conclusion
Use of TTh increased the risk of CVD, CAD, and stroke among cisgender women but not among transgender people. TTh is becoming more widely accepted in women, and it is the main medical treatment for transgender males. Therefore, use of TTh should be further investigated for the prevention of CVD.
Chromatin Organization and Transcriptional Programming of Breast Cancer Cell Identity
Authors: Bobbitt Jessica R , Seachrist Darcie D , Keri Ruth A 
Published: June 2023

Abstract
The advent of sequencing technologies for assessing chromosome conformations has provided a wealth of information on the organization of the 3-dimensional genome and its role in cancer progression. It is now known that changes in chromatin folding and accessibility can promote aberrant activation or repression of transcriptional programs that can drive tumorigenesis and progression in diverse cancers. This includes breast cancer, which comprises several distinct subtypes defined by their unique transcriptomes that dictate treatment response and patient outcomes. Of these, basal-like breast cancer is an aggressive subtype controlled by a pluripotency-enforcing transcriptome. Meanwhile, the more differentiated luminal subtype of breast cancer is driven by an estrogen receptor-dominated transcriptome that underlies its responsiveness to antihormone therapies and conveys improved patient outcomes. Despite the clear differences in molecular signatures, the genesis of each subtype from normal mammary epithelial cells remains unclear. Recent technical advances have revealed key distinctions in chromatin folding and organization between subtypes that could underlie their transcriptomic and, hence, phenotypic differences. These studies also suggest that proteins controlling particular chromatin states may be useful targets for treating aggressive disease. In this review, we explore the current state of understanding of chromatin architecture in breast cancer subtypes and its potential role in defining their phenotypic characteristics.
Fahr Syndrome Presenting With Status Epilepticus After COVID-19 Infection
Authors: Bitew Helen Yifter , Kambutse Immaculate , Tuyizere Aloys , Claude Gakumba 
Published: June 2023

Abstract
Hypoparathyroidism is a rare metabolic disease. In addition to symptoms of hypocalcemia, chronic hypoparathyroidism can result in brain calcifications leading to Fahr syndrome. Hypoparathyroidism most commonly results as a postsurgical complication, with autoimmune disease the second most common etiology. Here we report a 48-year-old man with symptoms of chronic hypocalcemia who presented with status epilepticus following severe coronavirus disease 2019 (COVID-19) infection. In addition to severe hypocalcemia, he was found to have an inappropriately low serum parathyroid hormone level and basal ganglia calcifications visualized on head computed tomography scan. He was treated with intravenous calcium infusion prior to transition to orally administered calcium, calcitriol, and high-dose cholecalciferol (vitamin D3).
Hunting with heat: thermosensory-driven foraging in mosquitoes, snakes and beetles
Authors: Laursen Willem J. , Tang Ruocong , Garrity Paul A. 
Published: June 2023

ABSTRACT
Animals commonly use thermosensation, the detection of temperature and its variation, for defensive purposes: to maintain appropriate body temperature and to avoid tissue damage. However, some animals also use thermosensation to go on the offensive: to hunt for food. The emergence of heat-dependent foraging behavior has been accompanied by the evolution of diverse thermosensory organs of often exquisite thermosensitivity. These organs detect the heat energy emitted from food sources that range from nearby humans to trees burning in a forest kilometers away. Here, we examine the biophysical considerations, anatomical specializations and molecular mechanisms that underlie heat-driven foraging. We focus on three groups of animals that each meet the challenge of detecting heat from potential food sources in different ways: (1) disease-spreading vector mosquitoes, which seek blood meals from warm-bodied hosts at close range, using warming-inhibited thermosensory neurons responsive to conductive and convective heat flow; (2) snakes (vipers, pythons and boas), which seek warm-blooded prey from ten or more centimeters away, using warmth-activated thermosensory neurons housed in an organ specialized to harvest infrared radiation; and (3) fire beetles, which maximize their offspring's feeding opportunities by seeking forest fires from kilometers away, using mechanosensory neurons housed in an organ specialized to convert infrared radiation into mechanosensory stimuli. These examples highlight the diverse ways in which animals exploit the heat emanating from potential food sources, whether this heat reflects ongoing metabolic activity or a recent lightning strike, to secure a nutritious meal for themselves or for their offspring.
Η μαγεία της μέτρησης αποστάσεων στους παγκόσμιους ψηφιακούς χάρτες: Πιλοτική εφαρμογή και βιωματικές προσεγγίσεις στην Πρωτοβάθμια Εκπαίδευση
Authors: Ρεπανίδου Ιωάννα , Λαμπρινός Νίκος 
Published: June 2023

Στη συγκεκριμένη έρευνα παρουσιάζεται μια πιλοτική εφαρμογή που διεξήχθη στα πλαίσια του μαθήματος της Γεωγραφίας σε δεκατέσσερις μαθητές/τριες της Στ’ τάξης του Δημοτικού Σχολείου. Μέσα από καθοδηγούμενη διερεύνηση και βιωματικές δράσεις, οι μαθητές/τριες έμαθαν για τις αλλοιώσεις των αποστάσεων μεταξύ των περιοχών-χωρών στους χάρτες και πειραματίστηκαν σε παγκόσμιους ψηφιακούς χάρτες Μερκατορικής προβολής. Πραγματοποιήθηκαν διδακτικές παρεμβάσεις σε διάστημα τεσσάρων εβδομάδων, όπου οι μαθητές/τριες διαπίστωσαν ότι η μικρότερη απόσταση μεταξύ δύο σημείων στη Μερκατορική προβολή είναι δυνατό να αποτελείται από μια καμπύλη γραμμή (ορθοδρόμος) κι όχι από μια ευθεία (λοξοδρόμος). Η Μερκατορική προβολή επιλέχθηκε καθώς χρησιμοποιείται συστηματικά και παγκοσμίως κι αποτελεί την κύρια χαρτογραφική προβολή που αξιοποιείται στο σχολικό περιβάλλον, ωστόσο η ίδια δημιουργεί παρανοήσεις στα παιδιά.
Czekając na muzeum: społeczna aktywność w poszukiwaniu pamięci zbiorowej na krakowskim Prądniku jako inspiracja do działań partycypacyjnych
Authors: Ozaist-Zgodzińska Zofia 
Published: June 2023

Mieszkańcy dwóch dzielnic na północy Krakowa podejmują zadania ustawowo przypisane do muzeów, nieświadomie wprowadzając zasady Nowej Muzeologii w życie społeczności. Nastawienie na przeżycie i interakcję widać w społecznych akcjach performatywnych, jak „protest saneczkowy” oraz w zainteresowaniu pojęciem „córectwa”. Charakter kontekstowy oznacza, że Prądniczanie kierują swoje zainteresowanie na ochronę dziedzictwa PRL-u. Poszanowanie prawe depozytariuszy widać w działaniach mających na celu udostępnienie publiczności zachowanej pracowni Beresiów. O krytycznym podejściu do własnej wiedzy świadczy to, że w budżetach obywatelskich mieszkańcy wybierają działania przybliżające lokalne dziedzictwo. Stały kontakt z publicznością oraz współtworzenie decyduje o popularności Wolnomuzykowania, Wypożyczalni Obrazów, wspólnego miejskiego ogrodnictwa oraz aneksji przestrzeni poprzez język. Prądniczanie zbudowali świadomą, idealną publiczność dla lokalnej placówki muzealnej - która na razie nie istnieje.
Factors predicting self-efficacy during birth in Chinese women: a cross-sectional study
Authors: Li Mao , Wacharasin Chintana , Tachasuksri Tatirat 
Published: June 2023

Background/AimsSelf-efficacy can promote optimism during childbirth and a better transition from pregnancy to motherhood. This study's aim was to examine maternal childbirth self-efficacy during the latent phase of labour, and identify related predictors, among low-risk Chinese pregnant women.MethodsA predictive correlational study was conducted among 122 low-risk pregnant women. Questionnaires were used to collect data on self-efficacy, with standard multiple linear regression analysis applied to determine its predictors.ResultsThe mean score for childbirth self-efficacy was 225 (standard deviation=47.86), which indicated moderate self-efficacy during labour. Professional support (P<0.001), childbirth knowledge (P<0.01) and parity (P<0.05) were significant predictors.ConclusionsThis study highlighted that professional support, childbirth knowledge and parity can affect childbirth self-efficacy, which could enhance women's coping ability and promote a successful birth. Healthcare professionals could increase maternal self-efficacy through providing enhanced emotional and information support, ensuring that women are given adequate information about the birth process and by providing support for primiparous women during the latent phase of labour.