bluuebunny/crossref_metadata_2025_split huggingface dataset:
Newsmaking Criminology: Korban Kejahatan Susila dalam Berita Media Online
Authors: Mony Husen , Wahyuni Desi 
Published: June 2023

In the perspective of newsmaking criminology, news about crime does not represent facts. Often, the media orchestrate the other side of the actual event to attract attention. The purpose of this study was to determine: 1) newsmaking criminology in the news of victims of sexual crimes; 2) a prominent dimension in the news. The method uses quantitative content analysis, with the national online media news population. The main concept is newsmaking criminology with 6 dimensions. The result is that these 6 dimensions appear in the news under study. The dimensions of identity and photo exploitation are raised through the loading of photos of the victims' families; the words used distort the meaning of the event and the behavior of the perpetrator; while victim blaming and news objectivity are present through shifting the focus of news to family issues; Stereotypes arise through information on the behavior of the victim that causes the perpetrator to commit his actions. The conclusion of this research is the most prominent dimension in reporting, from 828 news articles, which are published in 5 national online media, namely: 1) the use of words or phrases, as many as 59 findings; and 2) identification of 31 findings.
Abstrak
Dalam perspektif newsmaking criminology, berita tentang kejahatan tidak merepresentasikan fakta. Seringkali, media mengorkestrasi sisi lain dari peristiwa sebenarnya untuk menarik perhatian. Tujuan penelitian ini untuk mengetahui: 1) newsmaking criminology dalam berita korban kejahatan susila; 2) dimensi yang menonjol dalam berita tersebut. Metodenya menggunakan analisis isi kuantitatif, dengan populasi berita media online nasional. Konsep utamanya newsmaking criminoogy dengan 6 dimensi. Hasilnya adalah 6 dimensi tersebut muncul dalam berita yang diteliti. Dimensi identitas dan eksploitasi foto dimunculkan lewat pemuatan foto keluarga korban; kata-kata yang digunakan mendistorsi makna peristiwa dan perilaku pelaku; sedangkan victim blaming dan objektifitas berita hadir melalui penggeseran fokus berita ke isu-isu keluarga; stereotype muncul melalui informasi perilaku korban yang mengabitkan pelaku melakukan perbuatannya. Kesimpulan dari penelitian ini adalah dimensi yang paling menonjol dalam pemberitaan, dari 828 artikel berita, yang termuat pada pada 5 media online nasional, yaitu: 1) penggunaan kata atau frasa, sebanyak 59 temuan; dan 2) pencantuman identitas, sebanyak 31 temuan.
Penggunaan Platform Video Pendek Sebagai Strategi Komunikasi Pemasaran Digital untuk UMKM
Authors: Rozaq Miftahul , Nugrahani Rah Utami 
Published: June 2023

The short video platform via social media has become very popular in Indonesia and is one of the main tools for strategic communication for entrepreneurs. However, research regarding the use of short video platforms as a strategic communication tool for entrepreneurship is still limited and has not been discussed in depth. This study aims to identify and classify various uses of short video platforms as strategic communication tools for entrepreneurship. This research was conducted using a qualitative approach using a descriptive case study method with 12 entrepreneurs on the island of Java, Indonesia. In-depth interviews and observations were conducted to examine the use of short video platforms and communication strategies used by entrepreneurs. The results of the study show that the use of short video platforms by entrepreneurs includes; following viral content, using music features, educational content, and live streaming. While the communication strategies used include; entertainment and humor, sharing information and promotions, co-branding, and using people/influencer elements.
Abstrak
Platform video pendek buatan pengguna melalui media sosial menjadi sangat popular di Indonesia, dan menjadi salah satu alat utama untuk komunikasi strategis bagi wirausaha. Namun, penelitian terkait penggunaan platform video pendek sebagai alat komunikasi strategis untuk kewirausahaan masih terbatas dan belum dibahas secara mendalam. Penelitian ini bertujuan mengidentifikasi dan menklasifikasikan berbagai penggunaan platform video pendek sebagai alat komunikasi strategis untuk kewirausahaan. Penelitian ini dilakukan dengan pendekatan kualitatif menggunakan metode studi kasus deskriptif kepada 12 wirausaha di pulau Jawa, Indonesia. Wawancara mendalam dan observasi dilakukan untuk menkaji penggunaan platform video pendek dan strategi komunikasi yang digunakan wirausaha. Hasil penelitian menunjukkan, penggunaan platform video pendek oleh wirausaha antara lain; mengikuti konten viral, penggunaan fitur musik, konten edukasi, dan live streaming. Sedangkan strategi komunikasi yang digunakan antara lain; entertainment dan humor, membagikan informasi dan promosi, co-branding, dan penggunaan elemen orang/ influencer.
Effectiveness and safety of integrase strand transfer inhibitors in Spain: a prospective real-world study
Authors: Santos José Ramón , Casadellà Maria , Noguera-Julian Marc , Micán-Rivera Rafael , Domingo Pere , Antela Antonio , Portilla Joaquin , Sanz Jesús , Montero-Alonso Marta , Navarro Jordi , Masiá Mar , Valcarce-Pardeiro Nieves , Ocampo Antonio , Pérez-Martínez Laura , García-Vallecillos Coral , Vivancos María Jesús , Imaz Arkaitz , Iribarren José Antonio , Hernández-Quero José , Villar-García Judit , Barrufet Pilar , Paredes Roger ,   INSTINCT study group
Published: June 2023

IntroductionSecond-generation integrase strand transfer inhibitors (INSTIs) are preferred treatment options worldwide, and dolutegravir (DTG) is the treatment of choice in resource-limited settings. Nevertheless, in some resource-limited settings, these drugs are not always available. An analysis of the experience with the use of INSTIs in unselected adults living with HIV may be of help to make therapeutic decisions when second-generation INSTIs are not available. This study aimed to evaluate the real-life effectiveness and safety of dolutegravir (DTG), elvitegravir/cobicistat (EVG/c), and raltegravir (RAL) in a large Spanish cohort of HIV-1-infected patients.MethodsReal-world study of adults living with HIV who initiated integrase INSTIs DTG, EVG/c, and RAL-based regimens in three settings (ART-naïve patients, ART-switching, and ART-salvage patients). The primary endpoint was the median time to treatment discontinuation after INSTI-based regimen initiation. Proportion of patients experiencing virological failure (VF) (defined as two consecutive viral loads (VL) ≥200 copies/mL at 24 weeks or as a single determination of VL ≥1,000 copies/mL while receiving DTG, EVG/c or RAL, and at least 3 months after INSTI initiation) and time to VF were also evaluated.ResultsVirological effectiveness of EVG/c- and RAL-based regimens was similar to that of DTG when given as first-line and salvage therapy. Treatment switching for reasons other than virological failure was more frequent in subjects receiving EVG/c and, in particular, RAL. Naïve patients with CD4+ nadir &lt;100 cells/μL were more likely to develop VF, particularly if they initiated RAL or EVG/c. In the ART switching population, initiation of RAL and EVG/c was associated with both VF and INSTI discontinuation. There were no differences in the time to VF and INSTI discontinuation between DTG, EVG/c and RAL. Immunological parameters improved in the three groups and for the three drugs assessed. Safety and tolerability were consistent with expected safety profiles.DiscussionWhereas second-generation INSTIs are preferred treatment options worldwide, and DTG is one of the treatment of choices in resource-limited settings, first-generation INSTIs may still provide high virological and immunological effectiveness when DTG is not available.
Characterization of ultrasound and postnatal pathology in fetuses with heterotaxy syndrome
Authors: Wu Qiumei , Guo Shan , Huang Biying , Ling Wen , Peng Longzhuang , Ma Hong , Chen Fa , Lyu Guorong , Liu Min , Qiu Xiuqing , Weng Zongjie 
Published: June 2023

BackgroundTo explore the diagnostic clues and abnormality spectrum of heterotaxy syndrome by prenatal ultrasonography and postnatal verification.MethodsThe prenatal ultrasonic data of 88 heterotaxy syndrome fetuses were analyzed retrospectively as left isomerism (LI) and right isomerism (RI). Prenatal ultrasound compared with the anatomical casting of the fetal body after labor induction, and the confirmatory postnatal diagnosis after delivery.ResultsFetal LI showed typical malformations of gastric vesicles on different sides from the heart, absence of hepatic segment of the inferior vena cava (IVC), abdominal aorta (AO) parallel with the azygos vein (AV), bilateral left bronchus, bilateral left atrial appendages, and polysplenia; intracardiac malformations of AV septal defects (AVSD), single atrium (SA), left ventricular outflow tract obstruction (LVOTO), and double-outlet right ventricle (DORV); and cardiac conduction abnormalities of sinus bradycardia and AV blockage. Fetal RI reported typical malformations of gastric vesicles on different sides from the heart, juxtaposition of the IVC with AO, anomalous pulmonary venous connection (APVC), asplenia, and bilateral right atrial appendages; intracardiac malformations of AVSD, SA, single ventricle, pulmonary atresia and stenosis, and DORV. The postnatal verification revealed 3 malformations misdiagnoses and 4 malformations missed diagnoses in LI fetuses and 10 misdiagnoses and 8 missed diagnoses in RI fetuses.ConclusionsThe proposed five-step prenatal ultrasonography has an important diagnostic value for the identification and classification of heterotaxy syndrome. The different sides of gastric vesicles and cardiac apex are important diagnostic clues for heterotaxy syndrome, featuring disconnected or hypoplastic IVC, typical complex cardiac malformation, and atrioventricular block in fetal LI, and shown APVC, juxtaposition of IVC and AO, and intracardiac malformations such as AVSD, DORV, and LVOTO in fetal RI.
Sarcopenia prevalence and association with nutritional status in cohort of elderly patients affected by musculoskeletal concerns: a real-life analysis
Authors: Maccarone Maria Chiara , Coraci Daniele , Bernini Andrea , Sarandria Nicola , Valente Marta Rossella , Frigo Anna Chiara , Dionyssiotis Yannis , Masiero Stefano 
Published: June 2023

IntroductionThe progressive loss of skeletal muscle mass, strength, and function that frequently occurs as people get older is referred to as sarcopenia. Elderly musculoskeletal aging, sarcopenia, and obesity are all intimately connected. Our study’s aim is to investigate the prevalence of sarcopenia in a real cohort of patients over 65 with musculoskeletal conditions referring to a Rehabilitation Unit. The secondary aim of our study is to investigate associations between sarcopenia and alterations in nutritional status and Body Mass Index (BMI). Finally, quality of life and global health has been investigated in our population.Materials and methodsFrom January 2019 to January 2021, 247 patients over 65 years old with musculoskeletal concerns were enrolled and participated in an observational study. As outcome measures, the Mini Nutritional Assessment (MNA), the 12-Item Short Form Health Survey (SF-12), and the Cumulative Illness Rating Scale Severity Index (CIRS-SI) were used. Additionally, measurements of total skeletal muscle mass (SMM) and appendicular muscle mass (ASMM) using bioelectrical impedance analysis, as well as a hand grip strength test of the non-dominant hand were taken. The Mid Upper Arm Circumference (MUAC) and the Calf Circumference (CC) were measured and recorded as further indications of possible sarcopenia.ResultsA percentage of 46.1% of subjects with overt sarcopenia was found and 10.1% showed a severe sarcopenia. Patients with severe sarcopenia showed significantly lower values of BMI and MNA. Additionally, sarcopenic patients showed significantly lower values in MNA when compared to non-sarcopenic patients. Considering SF-12, only the physical score revealed slight significant differences. In particular, patients affected by probable or severe sarcopenia presented a lower value than non-sarcopenic patients. Concerning MUAC and CC, severe sarcopenic patients showed significant lower values for both the body parts.ConclusionOur study considers a cohort of real-life elderly subjects with musculoskeletal concerns and shows that these subjects are highly susceptible to sarcopenia. Therefore, rehabilitation for elderly patients with musculoskeletal concerns requires to be customized and multidisciplinary. Future research should further investigate these aspects in order to enable the early identification of sarcopenia and the formulation of customized rehabilitative programs.
Bromodomain-containing Protein 4 regulates innate inflammation via modulation of alternative splicing
Authors: Mann Morgan W. , Fu Yao , Gearhart Robert L. , Xu Xiaofang , Roberts David S. , Li Yi , Zhou Jia , Ge Ying , Brasier Allan R. 
Published: June 2023

IntroductionBromodomain-containing Protein 4 (BRD4) is a transcriptional regulator which coordinates gene expression programs controlling cancer biology, inflammation, and fibrosis. In the context of airway viral infection, BRD4-specific inhibitors (BRD4i) block the release of pro-inflammatory cytokines and prevent downstream epithelial plasticity. Although the chromatin modifying functions of BRD4 in inducible gene expression have been extensively investigated, its roles in post-transcriptional regulation are not well understood. Given BRD4's interaction with the transcriptional elongation complex and spliceosome, we hypothesize that BRD4 is a functional regulator of mRNA processing.MethodsTo address this question, we combine data-independent analysis - parallel accumulation-serial fragmentation (diaPASEF) with RNA-sequencing to achieve deep and integrated coverage of the proteomic and transcriptomic landscapes of human small airway epithelial cells exposed to viral challenge and treated with BRD4i.ResultsWe discover that BRD4 regulates alternative splicing of key genes, including Interferon-related Developmental Regulator 1 (IFRD1) and X-Box Binding Protein 1 (XBP1), related to the innate immune response and the unfolded protein response (UPR). We identify requirement of BRD4 for expression of serine-arginine splicing factors, splicosome components and the Inositol-Requiring Enzyme 1 IREα affecting immediate early innate response and the UPR.DiscussionThese findings extend the transcriptional elongation-facilitating actions of BRD4 in control of post-transcriptional RNA processing via modulating splicing factor expression in virus-induced innate signaling.
Sex differences in the evaluation of proteinuria using the urine dipstick test
Authors: Kojima Chiari , Umemura Hiroshi , Shimosawa Tatsuo , Nakayama Tomohiro 
Published: June 2023

BackgroundThe urine protein dipstick test is widely used, but false-positive and false-negative results may occur. This study aimed to compare the urine protein dipstick test with a urine protein quantification method.MethodsThe data were extracted using the Abbott Diagnostic Support System, which analyzes the inspection results using multiple parameters. This study included 41,058 specimens tested using the urine dipstick test and protein creatinine ratio from patients aged ≥18 years. The proteinuria creatinine ratio was classified according to the Kidney Disease Outcomes Quality Initiative guidelines.ResultsUrine protein on the dipstick test was negative in 15,548 samples (37.9%), trace in 6,422 samples (15.6%), and ≥1+ in 19,088 samples (46.5%). Among the trace proteinuria samples, A1 (&lt;0.15 g/gCr), A2 (0.15–0.49 g/gCr), and A3 (≥0.5 g/gCr) category proteinuria accounted for 31.2, 44.8, and 24.0% of samples, respectively. All trace proteinuria specimens with a specific gravity of &lt;1.010 were classified as A2 and A3 category proteinuria. In the trace proteinuria cases, women had a lower specific gravity and a higher percentage of A2 or A3 category proteinuria than men. The sensitivity in the “dipstick proteinuria” ≥ trace” group was higher than that in the “dipstick proteinuria ≥ 1+” group within the lower specific gravity group. The sensitivity in the “dipstick proteinuria ≥ 1+” group was higher for men than for women, and the sensitivity in the “dipstick proteinuria ≥ trace” group was higher than that in the “dipstick proteinuria ≥ 1+” group for women.ConclusionPathological proteinuria assessment requires caution; this study suggests that evaluating the specific gravity of urine specimens with trace proteinuria is essential. Particularly for women, the sensitivity of the urine dipstick test is low, and caution is needed even with trace specimens.
Dual consistent pseudo label generation for multi-source domain adaptation without source data for medical image segmentation
Authors: Cai Binke , Ma Liyan , Sun Yan 
Published: June 2023

IntroductionUnsupervised domain adaptation (UDA) aims to adapt a model learned from the source domain to the target domain. Thus, the model can obtain transferable knowledge even in target domain that does not have ground truth in this way. In medical image segmentation scenarios, there exist diverse data distributions caused by intensity in homogeneities and shape variabilities. But multi source data may not be freely accessible, especially medical images with patient identity information.MethodsTo tackle this issue, we propose a new multi-source and source-free (MSSF) application scenario and a novel domain adaptation framework where in the training stage, we only get access to the well-trained source domain segmentation models without source data. First, we propose a new dual consistency constraint which uses domain-intra and domain-inter consistency to filter those predictions agreed by each individual domain expert and all domain experts. It can serve as a high-quality pseudo label generation method and produce correct supervised signals for target domain supervised learning. Next, we design a progressive entropy loss minimization method to minimize the class-inter distance of features, which is beneficial to enhance domain-intra and domain-inter consistency in turn.ResultsExtensive experiments are performed for retinal vessel segmentation under MSSF condition and our approach produces impressive performance. The sensitivity metric of our approach is highest and it surpasses other methods with a large margin.DiscussionIt is the first attempt to conduct researches on the retinal vessel segmentation task under multi-source and source-free scenarios. In medical applications, such adaptation method can avoid the privacy issue. Furthermore, how to balance the high sensitivity and high accuracy need to be further considered.
Trading mental and physical health in vestibular schwannoma treatment decision
Authors: Machetanz Kathrin , Lee Larissa , Wang Sophie S. , Tatagiba Marcos , Naros Georgios 
Published: June 2023

ObjectiveObservation, radiotherapy and surgery are treatment options in vestibular schwannomas (VS). Decision making differs between centers and is usually based on tumor characteristics (e.g., size) and the expected physical health (PH) outcome (i.e., hearing and facial function). However, mental health (MH) is often under-reported. The objective of the present study was to ascertain the impact of VS treatment on PH and MH.MethodsPH and MH were assessed in a prospective cross-sectional study including 226 patients with unilateral sporadic VS before and after surgical removal (SURG). Quality-of-life (QoL) was estimated by self-rating questionnaires: general Short-Form Health Survey (SF-36), Penn Acoustic Neuroma Quality-of-Life Scale (PANQOL), Dizziness Handicap Inventory (DHI), Hearing Handicap Inventory (HHI), Tinnitus Handicap Inventory (THI), and Facial Disability Index (FDI). QoL changes over time as well as predictive factors were accessed by multivariate analyses of covariance (MANCOVA).ResultsIn total, 173 preoperative and 80 postoperative questionnaires were analyzed. There was a significant PH deterioration related to facial function (FDI, PANQOL-face) after surgery. In line with facial rehabilitation, however, FDI improved within the first five years after surgery and did not differ compared to the preoperative patient cohort, eventually. In contrast, MH (i.e., PANQOL-anxiety) and general health (i.e., PANQOL-GH) improved with surgery and correlated with the extent-of-resection.ConclusionPhysical and mental health is significantly influenced by VS surgery. While PH might decrease after surgery, MH potentially increases when patient is cured. Practitioners should take MH into account before advising an incompletely VS treatment (e.g., subtotal resection, observation or radiosurgery).
Perioperative, functional, and oncologic outcomes after ablation or partial nephrectomy for solitary renal tumors: a systematic review and meta-analysis of comparative trials
Authors: Wen Zhi , Wang Li , Huang Jing , Liu Yang , Chen Cai-xia , Wang Chong-jian , Chen Lin-lin , Yang Xue-song 
Published: June 2023

ObjectivesThe perioperative, functional, and oncological outcomes of patients with solitary small renal tumors (SRMs) treated with ablation (AT) or partial nephrectomy (PN) remain controversial. The aim of this study was to compare the outcomes of these two surgical techniques.MethodsIn April 2023, we conducted a literature search in several widely used databases worldwide, including PubMed, Embase, and Google Scholar. Review Manager was used to compare various parameters. The study was registered with PROSPERO (CRD42022377157).ResultsOur final meta-analysis included 13 cohort studies with a total of 2,107 patients. Compared to partial nephrectomy (PN), ablation (AT) had shorter hospital stays (WMD -2.37 days, 95% CI -3.05 to -1.69; p &lt; 0.00001), shorter operating times (WMD -57.06 min, 95% CI -88.92 to -25.19; p = 0.0004), less postoperative creatinine increases (WMD -0.17 mg/dL, 95% CI -0.29 to -0.05; p = 0.006), less postoperative glomerular filtration rate decreases (WMD -9.84 mL/min/1.73 m2, 95% CI -14.25 to -5.44; p &lt; 0.0001), less postoperative new-onset chronic kidney disease (OR 0.33, 95% CI 0.16 to 0.71; p = 0.005), and less intraoperative blood loss (WMD -285.92 ml, 95% CI -428.44 to -143.40; p &lt; 0.0001). The transfusion rate was lower in the ablation group (OR 0.17, 95% CI 0.06 to 0.51; p = 0.001). The risk of local recurrence was higher in the ablation group (OR 2.96, 95% CI 1.27 to 6.89; p = 0.01), while the risk of distant metastasis was higher in the partial nephrectomy group (OR 2.81, 95% CI 1.28 to 6.18; p = 0.01). The intraoperative and postoperative complication rates were lower in the ablation group (OR 0.23, 95% CI 0.08 to 0.62; p = 0.004 and OR 0.21, 95% CI 0.11 to 0.38; p &lt; 0.00001, respectively). However, overall survival, postoperative dialysis rate, and tumor-specific survival were not different between the two groups.ConclusionsOur data suggest that ablation and partial nephrectomy are equally safe and effective in the treatment of small solitary kidney tumors and are better options for patients with poor preoperative physical condition or poor renal function.