bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface‐enhanced Raman imaging of intact cancer cell membrane on a rough aluminum substrate
Authors: Ambardar Sharad , Binder Grace , Huynh Phat K. , Nguyen Dang , Hrim Hana , Le Trung Q. , Voronine Dmitri V. 
Published: June 2023

AbstractThe plasma membrane of cancer cells displays differences in lipid and protein composition which distinguish them from healthy cells. Certain molecules have such prominent vibrational characteristics that they can be considered cancer biomarkers. Although Raman spectroscopy is a label‐free non‐invasive method of chemical analysis, it, however, has been limited by weak signals from the membrane compared to the bulk interior of cells. Surface‐enhanced Raman scattering (SERS) on plasmonic gold and silver substrates has previously been used to overcome this limitation. However, the high cost, poor repeatability, and toxicity of these noble metals hinder their practical applications. These challenges may be solved by using different materials and nanostructures. Here, we performed SERS imaging of ovarian cancer cells on rough aluminum substrates and extracted the Raman signals of intact cell membranes by comparing these with the corresponding measurements on Si substrates. We used atomic force microscopy (AFM) for Raman signal calibration. The comparison of cancer and normal cell membranes revealed the different lipid/protein peak ratios in cytoplasm and nucleus‐proximal areas. These Raman signatures of the ovarian cancer can be used as new biomarkers. This method may be extended to other types of cancer biosensing based on aluminum plasmonics.
Physicochemical and functional property of the Maillard reaction products of soy protein isolate with L‐arabinose/D‐galactose
Authors: Zhang Qiyun , Dou Lanxing , Sun Tao , Li Xiaohui , Xue Bin , Xie Jing , Bian Xiaojun , Shao Zehuai , Gan Jianhong 
Published: June 2023

AbstractBACKGROUNDSoy protein isolate (SPI) is widely used in the food industry because of its nutritional and functional properties. During food processing and storage, the interaction with co‐existing sugars can cause changes in the structural and functional properties of SPI. In this study, SPI–l‐arabinose conjugate (SPI:Ara) and SPI–d‐galactose conjugate (SPI:Gal) were prepared using Maillard reaction (MR), and the effects of five‐carbon/six‐carbon sugars on the structural information and function of SPI were compared.RESULTSMR unfolded and stretched the SPI, changing its ordered conformation into disorder. Lysine and arginine of SPI were bonded with the carbonyl group of sugar. The MR between SPI and l‐arabinose has a higher degree of glycosylation compared to d‐galactose. MR of SPI enhanced its solubility, emulsifying property and foaming property. Compared with SPI:Ara, SPI:Gal exhibited better aforementioned properties. The functionalities of amphiphilic SPI were enhanced by MR, SPI:Gal possessed better hypoglycemic effect, fat binding capacity and bile acid binding ability than SPI:Ara. MR endowed SPI with enhanced biological activities, SPI:Ara showed higher antioxidant activities, and SPI:Gal exhibited stronger antibacterial activities.CONCLUSIONOur work revealed that l‐arabinose/d‐galactose exhibited different effects on the structural information of SPI, and further affected its physicochemical and functional property. © 2023 Society of Chemical Industry.
An Injectable and Antifouling Supramolecular Polymer Hydrogel with Microenvironment‐Regulatory Function to Prevent Peritendinous Adhesion and Promote Tendon Repair
Authors: Wang Kuan , Chen Danyang , Wang Zhuoya , Yang Jianhai , Liu Wenguang 
Published: June 2023

AbstractThe imbalance of extrinsic and intrinsic healing of tendon is thought to be the main cause of peritendinous adhesions. In this work, an injectable supramolecular poly(N‐(2‐hydroxypropyl) acrylamide) (PHPAm) hydrogel is prepared merely via side chain hydrogen‐bonding crosslinks. This PHPAm exhibits good antifouling and self‐healing properties. The supramolecular hydrogel simultaneously loaded with Prussian blue (PB) nanoparticles and platelet lysate (PL) is explored as a functional physical barrier, which can significantly resist the adhesion of fibrin and fibroblasts, attenuate the local inflammatory response, and enhance the tenocytes activity, thus balancing extrinsic and intrinsic healing. The PHPAm hydrogel is shown to prevent peritendinous adhesions considerably by inhibiting NF‐κB inflammatory pathway and TGF‐β1/Smad3‐mediated fibrosis pathway, thereby significantly improving tendon repair by releasing bioactive factors to regulate the tenocytes behavior. This work provides a new strategy for developing physical barriers to prevent peritendinous adhesions and promote tissue repair effectively.
Cellular Membrane Components‐Mediated Cancer Immunotherapeutic Platforms
Authors: Yun Seojeong , Kim Sungjun , Kim Kyobum 
Published: June 2023

AbstractImmune cell engineering is an active field of ongoing research that can be easily applied to nanoscale biomedicine as an alternative to overcoming limitations of nanoparticles. Cell membrane coating and artificial nanovesicle technology have been reported as representative methods with an advantage of good biocompatibility for biomimetic replication of cell membrane characteristics. Cell membrane‐mediated biomimetic technique provides properties of natural cell membrane and enables membrane‐associated cellular/molecular signaling. Thus, coated nanoparitlces (NPs) and artificial nanovesicles can achieve effective and extended in vivo circulation, enabling execution of target functions. While coated NPs and artificial nanovesicles provide clear advantages, much work remains before clinical application. In this review, first a comprehensive overview of cell membrane coating techniques and artificial nanovesicles is provided. Next, the function and application of various immune cell membrane types are summarized.
Continuous fiber reinforced thermoplastic composite pultrusion with in situ polymerizable methyl methacrylate: A review
Authors: Tian Lingyu , Zhang Puxuan , Xian Guijun 
Published: June 2023

AbstractCompared to thermosetting resins, thermoplastic polymers offer many advantages as fiber reinforced composite matrices, such as excellent toughness, superior corrosion resistance, weldability, and recyclable, etc. However, the processibility of thermoplastic composites is commonly considered as a challenge because of the high viscosity of polymer melts (e.g., polypropylene, polyetheretherketone, etc.), which remarkably hinders their applications. Using low viscosity and in situ polymerizable thermoplastic resins to manufacture continuous fiber reinforced thermoplastic composites have been deemed as a cost‐effective emerging approach to surpass the processibility challenges. Therefore, this paper presents an overview of advancement in the engineering, high‐performance and room‐temperature‐processible liquid methyl methacrylate (MMA) resins and their composites up to date. First, the polymerization behavior and kinetic modeling of the MMA resins are reviewed, and the effects of initiators on the polymerization are summarized. In the second part, the pultrusion process and modeling including impregnation, temperature distribution and pulling force are discussed. Next, the mechanical properties and durability of the carbon fiber‐, glass fiber‐reinforced MMA‐matrix composites are presented. Finally, the challenges of the preparation and application of the MMA‐matrix composites are identified.
Copper and graphene work together to construct a three‐dimensional skeleton thermal conductivity network to improve the thermal conductivity of the epoxy resin
Authors: Li Shuo , Wu Wei , Drummer Dietmar , Wang Yi , Lu Zijian , Zhao Xintong 
Published: June 2023

AbstractWith the development of integrated circuits, the miniaturization and integration of electronic devices has become a development trend, and the demand for heat dissipation is also increasing. Graphene three‐dimensional aerogels prepared from graphene has been widely used in the field of thermal management materials, but graphene aerogels also face the disadvantages of poor compatibility with resin matrix and high thermal resistance. In this study, a hybrid filler for depositing copper nanoparticles on the surface of graphene aerogel was prepared, and the hybrid aerogel filler showed excellent thermal conductivity, reduced the interfacial thermal resistance and contact thermal resistance, improved the interfacial thermal resistance with epoxy resin, and improved the interfacial compatibility. Under a low load of 2.5 wt%, the thermal conductivity of the prepared composite is as high as 2.09 Wm−1 K−1, which is about 11 times that of pure epoxy resin. It provides a simple idea for preparing high‐thermal conductivity three‐dimensional graphene epoxy resin composites with high thermal conductivity.
Effects of radiation on the fitness, sterility and arbovirus susceptibility of aWolbachia‐freeAedes albopictusstrain for use in the sterile insect technique
Authors: Zhang Dong‐jing , Sun Yan , Yamada Hanano , Wu Yu , Wang Gang , Feng Qing‐deng , Paerhande Dilinuer , Maiga Hamidou , Bouyer Jérémy , Qian Jun , Wu Zhong‐dao , Zheng Xiao‐ying 
Published: June 2023

AbstractBACKGROUNDThe sterile insect technique (SIT) is a green and species‐specific insect pest control technique that suppresses target populations by releasing factory‐reared, radiosterilized males into the wild. Once released, it is important to be able to distinguish the released males from the wild males for monitoring purposes. Several methods to mark the sterile males exist. However, most have limitations due to monetary, process efficiency, or insect quality.Aedes albopictusis naturally infected withWolbachiaat a high prevalence, therefore the elimination ofWolbachiacan serve as a biomarker to distinguish factory‐reared male mosquitoes from wild conspecifics.RESULTSIn this study, aWolbachia‐freeAe. albopictusGT strain was developed and its fitness evaluated, which was found to be comparable to the wild GUA strain. In addition, GT male mosquitoes were irradiated at the adult stage and a dose of 20 Gy or more induced over 99% sterility. Moreover, a dose of 30 Gy (almost completely sterilizing male and female mosquitoes) had limited effects on the mating competitiveness of GT males and the vector competence of GT females, respectively. However, radiation reduced mosquito longevity, regardless of sex.CONCLUSIONOur results indicate that theAe. albopictusGT strain can be distinguished from wild mosquitoes based onWolbachiastatus and shows similar fitness, radio‐sensitivity and arbovirus susceptibility to the GUA strain, indicating that it is feasible to use the GT strain to suppressAe. albopictuspopulations for SIT programmes. © 2023 The Authors.Pest Management Sciencepublished by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Age, gender, and cohort in residential segregation: The case of African immigrants in Spain, 2000–2020
Authors: Gastón‐Guiu Silvia , Bayona‐i‐Carrasco Jordi 
Published: June 2023

AbstractThe composition of the immigrant population by gender and age, and characteristics at the moment of arrival plays an influential role in the levels of residential segregation reached, and in their evolution over time. In Spain, the African immigrant population is notable for a marked gender imbalance, where men outnumber women, and for continuous growth in the number of immigrants over the past two decades. It is also one of the groups presenting the highest levels of segregation. Using data from the Continuous Population Register, this study analyses the residential segregation of this group from the triple perspective of age, period, and cohort for the six main Spanish cities. The results reveal a significant differentiation in segregation levels by sex and age, with lower rates in the more recent cohorts. This perspective offers a dynamic view of segregation indicators and enables better understanding of its future evolution.
Spectro‐Microscopic Perceptions into Oxidation Behavior of Large‐Scale Molybdenum Disulfide and its Photoelectrical Correlation
Authors: Kwon Yeong Min , Lim Yi Rang , Bae Garam , Song Da Som , Jo Hyeong‐ku , Park Se Yeon , Jang Moonjeong , Yim Soonmin , Myung Sung , Lim Jongsun , Lee Sun Sook , Song Wooseok 
Published: June 2023

AbstractDespite the encouraging properties and research of 2D MoS2, an ongoing issue associated with the oxidative instability remains elusive for practical optoelectronic applications. Thus, in‐depth understanding of the oxidation behavior of large‐scale and homogeneous 2D MoS2 is imperative. Here the structural and chemical transformations of large‐area MoS2 multilayers by air‐annealing with altered temperature and time via combinatorial spectro‐microscopic analyses (Raman spectroscopy, X‐ray photoelectron spectroscopy, and atomic force microscopy) are surveyed. The results gave indications pertaining to temperature‐ and time‐dependent oxidation effects: i) heat‐driven elimination of redundant residues, ii) internal strain stimulated by the formation of MoO bonds, iii) deterioration of the MoS2 crystallinity, iv) layer thinning, and v) morphological transformation from 2D MoS2 layers to particles. Photoelectrical characterization of the air‐annealed MoS2 is implemented to capture the link between the oxidation behavior of MoS2 multilayers and their photoelectrical properties. The photocurrent based on MoS2 air‐annealed at 200 °C is assessed to be 4.92 µA, which is 1.73 times higher than that of pristine MoS2 (2.84 µA). The diminution in the photocurrent of the photodetector based on MoS2 air‐annealed above 300 °C in terms of the structural, chemical, and electrical conversions induced by the oxidation process is further discussed.
Superhydrophilic Triazine‐Based Covalent Organic Frameworks via Post‐Modification of FeOOH Clusters for Boosted Photocatalytic Performance
Authors: Wang Yue , Deng Yang , Xia Hong , Zhang Ruizhong , Liu Jia , Zhang Haixia , Sun Yajing , Zhang Zhen , Lu Xiaoquan 
Published: June 2023

AbstractThe triazine‐based covalent organic frameworks (tCOF), an intriguing subtype of COFs, are expected as highly promising photocatalysts for various photocatalytic applications owing to their fully conjugated structures and nitrogen‐rich skeletons. However, the inherent hydrophobicity and fast recombination of photoexcited electron‐hole pairs are two main factors hindering the application of tCOF in practical photocatalytic reactions. Here, a post‐synthetic modification strategy to fabricate superhydrophilic tCOF‐based photocatalysts is demonstrated by in situ growing FeOOH clusters on TaTz COF (TaTz‐FeOOH) for efficient photocatalytic oxidation of various organic pollutants. The strong polar FeOOH endows TaTz‐FeOOH with good hydrophilic properties. The well‐defined heterogeneous interface between FeOOH and TaTz allows the photoelectrons generated by TaTz to be consumed by Fe (III) to transform into Fe (II), synergistically promoting the separation of holes and the generation of free radicals. Compared with the unmodified TaTz, the optimized TaTz‐FeOOH (1%) shows excellent photocatalytic performance, where the photocatalytic degrade rate (k) of rhodamine B is increased by about 12 times, and the degradation rate is maintained at 99% after 5 cycles, thus achieving efficient removal of quinolone antibiotics from water. This study provides a new avenue for the development of COF‐based hydrophilic functional materials for a wide range of practical applications.
Liquid‐Metal‐Assisted Synthesis of Patterned GaN Thin Films for High‐Performance UV Photodetectors Array
Authors: Du Yuchen , Yin Shiqi , Li Ying , Chen Jiawang , Shi Dongfeng , Guo Erjuan , Zhang Hui , Wang Zihan , Qin Qinggang , Zou Chongwen , Zhai Tianyou , Li Liang 
Published: June 2023

AbstractGaN's outstanding physical characteristics allow for a wide range of applications in numerous industries. Although individual GaN‐based ultraviolet (UV) photodetectors are the subject of in‐depth research in recent decades, the demand for photodetectors array is rising as a result of advances in optoelectronic integration technology. However, as a prerequisite for constructing GaN‐based photodetectors array, large‐area, patterned synthesis of GaN thin films remains a certain challenge. This work presents a facile technique for pattern growing high‐quality GaN thin films for the assembly of an array of high‐performance UV photodetectors. This technique uses UV lithography, which is not only very compatible with common semiconductor manufacturing techniques, but also enables precise patterning modification. A typical detector has impressive photo‐response performance under 365 nm irradiation, with an extremely low dark current of 40 pA, a high Ilight/Idark ratio over 105, a high responsivity of 4.23 AW−1, and a decent specific detectivity of 1.76 × 1012 Jones. Additional optoelectronic studies demonstrate the strong homogeneity and repeatability of the photodetectors array, enabling it to serve as a reliable UV image sensor with enough spatial resolution. These outcomes highlight the proposed patterning technique's enormous potential.
Privacy preserving content distribution framework for multidistributor DRM systems
Authors: Mishra Ankita , Obaidat Mohammad S. , Mishra Dheerendra 
Published: June 2023

AbstractGrowing network technology and computing facilities present greater opportunities for the e‐commerce industry to sell digital content on an easily assessable platform. However, digital content creators need help due to digital content easily copying and redistributing without quality degradation. Digital rights management (DRM) systems are built up to deal with content piracy and effective distribution. However, traditional two‐party DRM systems are client–server architecture, which may create a bottleneck situation for large networks. At the same time, a multidistributor DRM (MD‐DRM) system can offer content distribution more effectively. However, as the number of distributors increases, chances of security and privacy vulnerability may increase. Thus, a MD‐DRM system requires with an effective mechanism of privacy‐preserving and secure content distribution. We proposed a privacy‐preserving and authorized content distribution framework that remains compatible with multiple distributors and single‐distributor architecture to achieve basic security attributes. Besides, the proposed scheme does not breach the key parameters of accountability. This mechanism makes traitor identification possible without violating the privacy rights of authorized consumers in multidistributor architecture.
Teaching English in the Muslim World against the Backdrop of 9/11 and Resurgent Nationalism: A Case Study of Bangladeshi ELT
Authors: Hamid M. Obaidul , Ali Md. Maksud 
Published: June 2023

AbstractThis article examines English language teaching (ELT) policy, textbooks, and pedagogy in the neo‐nationalist era that followed 9/11 in Muslim‐majority Bangladesh. Informed by the Douglas Fir Group's transdisciplinary framework of second language learning, the examination substantiates the ideologies of economization, de‐Islamization and awamization, which coalesce into the overarching ideology of secularization of ELT as a response to the global war on terror and the rise of neo‐nationalism in South Asia. This secular response to forces and developments in global, regional, and local contexts marks the distinctiveness of Bangladeshi ELT compared with other Muslim societies, which have sought to develop students' awareness of religious and cultural values while teaching English. The secularization of ELT can be explained by the rise of Hindutva nationalism in India and the latter's influence on the ruling Bangladesh Awami League government which has been in power for over 14 years. The article attests to the complex, multilayered ELT ideology shaped by local, regional, and global forces and interests, suggesting the formation of a national/social imaginary that seeks alliance with secular Muslims and non‐Muslim communities at home and in the region and excludes practicing Muslims in both contexts.
How many biomarker measurements are needed to predict prognosis in Crohn's disease patients under infliximab?—A prospective study
Authors: Magro Fernando , Estevinho Maria Manuela , Catalano Gaia , Patita Marta , Arroja Bruno , Lago Paula , Rosa Isadora , Tavares de Sousa Helena , Ministro Paula , Mocanu Irina , Vieira Ana , Castela Joana , Moleiro Joana , Roseira Joana , Cancela Eugénia , Sousa Paula , Portela Francisco , Correia Luís , Moreira Paula , Santiago Mafalda , Dias Sandra , Afonso Joana , Danese Silvio , Peyrin‐Biroulet Laurent , Dias Cláudia Camila ,   GEDII (Grupo de Estudos da Doença Inflamatória Intestinal)
Published: June 2023

AbstractBackgroundTimely stratification of Crohn's disease (CD) is essential for patients' management. The use of noninvasive accurate biomarkers is key to monitor treatment and to pursue mucosal healing, the ultimate treatment endpoint in CD.ObjectiveWe aimed to evaluate the performance of readily available biomarkers and develop risk matrices to predict CD progression.MethodsData from 289 CD patients receiving infliximab (IFX) maintenance therapy for 2 years was collected; those patients were included in DIRECT, a prospective multicenter observational study. Disease progression was evaluated using two composite outcomes incorporating clinical and drug‐related factors, the first including IFX dose and/or frequency adjustments. Univariate and multivariable logistic regressions were used to calculate the odds ratios (OR) and to develop risk matrices.ResultsThe isolated presence of anemia at least once during follow‐up was a significant predictor of disease progression (OR 2.436 and 3.396 [p ≤ 0.001] for composite outcomes 1 and 2, respectively) regardless of confounding factors. Isolated highly elevated C‐reactive protein (CRP; >10.0 mg/L) and fecal calprotectin (FC; >500.0 μg/g) in at least one visit were also significant predictors, while milder elevations (3.1–10.0 mg/L and 250.1–500.0 μg/g) were only relevant when detected in at least two visits (consecutive or not). The combination of biomarkers in risk matrices had good ability to predict progression; patients simultaneously presenting anemia, highly elevated CRP and FC at least once had 42%–63% probability of achieving the composite outcomes.ConclusionThe combined evaluation of hemoglobin, CRP, and FC in at least one time point and their incorporation into risk matrices seems to be the optimal strategy for CD management, as data from additional visits did not meaningfully influence the predictions and may delay decision‐making.