bluuebunny/crossref_metadata_2025_split huggingface dataset:
A psychological intervention based on cognitive‐behavioural therapy reduces psychopathological symptoms that indirectly influence the heart rate via cortisol in hypertensive patients: Preliminary results of a pilot study
Authors: Giordano Francesca , Guidotti Sara , Gelo Omar Carlo Gioacchino , Salerno Clemente , Pruneti Carlo 
Published: August 2023

AbstractObjectiveThis study aimed at assessing the effectiveness of cognitive‐behavioural therapy (CBT) integrated with psychoeducation in a group of hypertensive patients with clinically significant psychopathological symptoms.MethodsOne hundred hypertensive patients completed the Symptom Checklist‐90‐Revised. Of them, 17 scored above the clinical range (cut‐off = 0.75) on the Global Severity Index and were included in the study. Psychological distress was assessed again after the intervention (T1) and 6 months after the end of treatment (T2). In addition, the cortisol dosage and the heart rate (HR) measurement were collected at both T0 and T2. Then, mediation analyses were carried out to calculate whether psychopathological distress might predict HR through elevated serum cortisol levels, at both T0 and T2.ResultsThe psychological intervention (CBT integrated with psychoeducation) reduced most of the psychopathological symptoms (anxiety, depression, somatisations, obsessions and compulsions, hostility, interpersonal sensitivity and paranoid ideation) but not cortisol dosage and HR measurement. However, psychological distress indirectly predicted HR via cortisol at T0 but not at T2.ConclusionThese results suggest and encourage the replicability of data in larger sample sizes and the comparison with a control group. Nevertheless, these results highlight a need for a multidimensional assessment of disorders affecting the mental and physical spheres of patients to support their overall well‐being.
Terpenoids as Human Neutrophil Elastase (HNE) Inhibitors: A Comprehensive Review of Natural Anti‐inflammatory Isoprenoids
Authors: Tousif Muhammad Imran , Nazir Mamona , Riaz Naheed , Saleem Muhammad , Tauseef Saba , Azam Sheikh Muhammad , Arfan Yawer Mirza , Zengin Gokhan 
Published: August 2023

AbstractHuman neutrophil elastase (HNE) is an enzyme that plays a key role in the body‘s inflammatory response. It has been linked to several diseases such as chronic obstructive pulmonary disease (COPD), emphysema, and cystic fibrosis. As potential treatments for these diseases, HNE inhibitors are of great interest. Metabolites derived from plants, particularly terpenoids such as β‐caryophyllene found in black pepper and other plants, and geraniol present in several essential oils, are recognized as significant sources of inhibitors for HNE. Because of their ability to inhibit HNE, terpenoids are considered promising candidates for developing novel therapies to treat inflammatory conditions such as COPD and emphysema. Furthermore, nature can serve as an excellent designer, and it may offer a safer drug candidate for inhibiting HNE production and activity in the future. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses were searched to get relevant and up‐to‐date literature on terpenoids as human neutrophil elastase inhibitors. This review focuses on the isolation, chemical diversity, and inhibition of human neutrophil elastase (HNE) of various terpenoids reported from natural sources up to 2022. A total of 251 compounds from various terpenoids classes have been reported. Further, it also provides a summary of HNE inhibitors and includes a thorough discussion on the structure‐activity relationship.
A rare extrapulmonary manifestation of tuberculosis in a chronic kidney disease patient
Authors: Sivanandam Lokesh Koumar , Jhoond Manpreet Kaur , Sujanyal Saurabh Ashok , Sridhar Shreya , Nasser Nathalie , Sanker Vivek , Gupta Umang 
Published: August 2023

Key Clinical MessageChronic kidney disease (CKD) and tuberculoma are two distinct medical conditions. Nonetheless, they can be related in very rare cases. The purpose of this case report is to consider screening tests such as IGRA (interferon gamma release assay) and TST (tuberculin skin test), for tuberculosis in CKD patients with a risk of infection, thereby increasing the awareness of tuberculoma in CKD and ensuring early treatment which would eventually decrease the morbidity and mortality rates in such patients.AbstractChronic kidney disease (CKD) associated with tuberculoma represents one of the rarest conditions occurring worldwide. Among tuberculous patients, only 1% show central nervous system involvement. We present a case of a 45‐year‐old male with CKD who presented with a seizure and was diagnosed to have tuberculoma.
Surgical, endovascular, and hybrid treatment of deep femoral artery aneurysm: Three case reports
Authors: Moriuchi Hiroki , Maeda Takuya , Koide Masaaki , Kunii Yoshifumi , Watanabe Kazumasa 
Published: August 2023

Key Clinical MessageDeep femoral artery aneurysms (DFAA) are extremely rare. We treated four DFAAs with different procedures including surgical, endovascular, and hybrid surgery. The best treatment should be selected for each individual case.AbstractWe report three cases of deep femoral artery aneurysms treated with different techniques. Case 1: A 69‐year‐old man with a huge deep femoral artery aneurysm underwent open reconstruction using a 6 mm expanded polytetrafluoroethylen graft. Case 2: A 67‐year‐old man presented with bilateral deep femoral artery aneurysms. The right‐sided rupture was treated with hybrid embolization, while the left aneurysm was treated by endovascular stent‐grafts deployment. Case 3: A 87‐year‐old man with a large deep femoral artery aneurysm underwent simply surgical aneurysmectomy. As there are many treatment options for deep femoral artery aneurysms, a comprehensive preoperative assessment is essential, encompassing an evaluation of symptoms, anatomy, and comorbidities.
Recent Advances of Aqueous Electrolytes for Zinc‐Ion Batteries to Mitigate Side Reactions: A Review
Authors: Gao Xuan , Dong Haobo , Carmalt Claire J. , He Guanjie 
Published: August 2023

AbstractThe paper discusses the challenges associated with the performance of zinc‐ion batteries (ZIBs), such as side reactions that lead to reduced capacity and lifespan. The strategies for mitigating side reactions in ZIBs, including additives, electrolyte‐electrode interface modification, and electrolyte composition optimization, are explored. Combinations of these approaches may be necessary to achieve the best performance for ZIBs. However, continued research is needed to improve the commercial viability of ZIBs. Areas of research requiring attention include the understanding of the mechanisms behind side reactions in ZIBs and the development of cost‐effective and scalable manufacturing processes for ZIBs with available electrolyte. By developing effective strategies for mitigating side reactions, researchers can improve the efficiency and lifespan of ZIBs, making them more competitive with lithium‐ion batteries in various applications, including grid energy storage.
Green and Facile Preparation of Covalent Organic Frameworks Based on Reaction Medium for Advanced Applications
Authors: Azadi Elham , Dinari Mohammad 
Published: August 2023

AbstractCovalent organic frameworks (COFs), as a new class of crystalline, well‐ordered, and porous materials with intermittent constructions, are formed via organic structural parts connected through covalent bonds. These materials have been employed in several fields comprising pollutant adsorption and separation, catalysis, electrical conductivity, gas storage, etc. The preparation of COFs is mainly applied in tubes with high temperatures and degassing treatment. Furthermore, the reaction medium is involved in toxic organic solvents like toluene, dioxane, mesitylene, acetonitrile, and so on. Hence, discovering clean medium and green approaches has attracted wide attention. Recently, facile, less dangerous, and greener methods have been developed for COFs synthesis in diverse applications like performing the reaction at ambient temperature or employing aqueous solvents, ionic liquids, and a mixture of organic solvents/water. This review article summarizes the eco‐friendly production approaches of COFs for diverse applications.
Dispersing LiCl in Zwitterionic COF for Highly Efficient Ammonia Storage and Separation
Authors: Fu Yu , Wu Yue , Zeng Jiahui , Wang Shanshan , Li Xiaoyu , Zhang Wenxiang , Ma Heping 
Published: August 2023

AbstractEfficient and inherently safe NH3 storage and separation are of significant importance for the chemical industry. Herein, we proposed zwitterionic COF as a porous host to disperse LiCl for highly efficient NH3 storage and separation with record adsorption capacity. The equivalently cationic and anionic groups in the channels of zwitterionic COF could act as two separated sites to facilitate the dispersion of LiCl, hence the optimal composite exhibits a high capture capacity of 44.98 mmol/g at 25 °C and 1 bar, far exceeding other existing porous materials. Notably, the adsorption capacity is completely reversible and the efficient separation of NH3 from NH3/CO2/N2 mixture is achieved through breakthrough experiments. DFT calculation combined with XPS and 7Li NMR experimental results give insight into the interaction between zwitterionic COF and LiCl. This work extends possibilities for the development of efficient adsorbents for NH3 storage and separation.
Cobalt‐Catalyzed Difunctionalization of Styrenes via Ligand Relay Catalysis†
Authors: Wang Bingcheng , Sun Yufeng , Lu Zhan 
Published: August 2023

Comprehensive SummaryHere, we report a cobalt‐catalyzed sequential dehydrogenative Heck silylation/hydroamination of styrenes with hydrosilane and diazo compound to access 1‐amino‐2‐silyl compounds with excellent regioselectivity. This difunctionalization reaction could undergo smoothly using 1 mol% catalyst loading with good functional group tolerance. Not only di‐ and tri‐substituted hydrosilanes, but also alkoxysilane is suitable, which does explore the scope of the family of 1‐amino‐2‐silyl compounds. The ligand relay phenomenon between neutral tridentate NNN ligand and anionic NNN ligand is observed for the first time via absorption spectral analysis in this one‐pot, two‐step transformations. The primary mechanism has been proposed based on the control experiments.
Development of Mixed Matrix Membranes with Penetrating Subnanochannels for Efficient Molecule/Ion Separation
Authors: Li Chen , Chen Xiao , Huang Cheng , Cheng Sha , Xu Shiqing , Jiang Yanan , Zhang Pengchao , Chen Wen 
Published: August 2023

AbstractMembrane‐based separation technologies are becoming increasingly prominent in many important industrial separation applications. In the past decade, nanoporous materials, as promising filler components for high‐performance mixed matrix membranes (MMMs), have seen a boom given the merits of remarkable chemical and structural variability. However, it remains challenging to address the trade‐off effect of MMMs between molecular/ionic selectivity and permeability. Biological ion channels that penetrate through cell membranes have provided new insights for the construction of novel structures of MMMs. In recent years, MMMs with cell membrane‐like structures have gained much attention and achieved significant progress in the field of separation. In this minireview, recent advances in the design and construction of MMMs with penetrating subnanochannels are summarized. After that, the applications of these MMMs with penetrating subnanochannels in gas separation and ion sieving are highlighted and discussed in detail. Finally, the future developments and challenges for the MMMs with penetrating subnanochannels are prospected.
Catalytic Graphitization of Biocarbon for Lithium‐Ion Anodes: A Minireview
Authors: Lower Lillian , Dey Shaikat Chandra , Vook Trevor , Nimlos Mark , Park Sunkyu , Sagues William Joe 
Published: August 2023

AbstractThe demand for electrochemical energy storage is increasing rapidly due to a combination of decreasing costs in renewable electricity, governmental policies promoting electrification, and a desire by the public to decrease CO2 emissions. Lithium‐ion batteries are the leading form of electrochemical energy storage for electric vehicles and the electrical grid. Lithium‐ion cell anodes are mostly made of graphite, which is derived from geographically constrained, non‐renewable resources using energy‐intensive and highly polluting processes. Thus, there is a desire to innovate technologies that utilize abundant, affordable, and renewable carbonaceous materials for the sustainable production of graphite anodes under relatively mild process conditions. This review highlights novel attempts to realize the aforementioned benefits through innovative technologies that convert biocarbon resources, including lignocellulose, into high quality graphite for use in lithium‐ion anodes.
Puke or poop? Comparison of regurgitate and faecal samples to infer alpine grasshopper (Paprides nitidus Hutton) diet in experimental plant communities
Authors: Allen Warwick J. , Waller Lauren P. , Barratt Barbara I. P. , Dickie Ian A. 
Published: August 2023

AbstractCharacterising plant‐herbivore interactions is important to understanding the processes that influence community structure and ecosystem functioning. Traditional methods used to identify plant‐herbivore interactions are being superseded by non‐destructive molecular approaches that can infer interactions with greater resolution and accuracy from environmental DNA (e.g. faeces and regurgitate). However, few studies have compared the success of using different sample types and whether they provide similar or contrasting information about species' diet. Here we compared the success of DNA amplification and host plant species identification using restriction fragment length polymorphism (RFLP) applied to faecal and regurgitate samples collected from alpine grasshoppers Paprides nitidus Hutton during a grassland community mesocosm experiment. We found that DNA amplification success was 23% and 86% higher for faecal than regurgitate samples from female and male grasshoppers, respectively. In contrast, successful host plant identification using RFLP was 9% higher for regurgitate than faecal samples. The mean number of host plant species identified per sample (1.40) did not differ between sample types or grasshopper sexes. Of the 136 paired faecal‐regurgitate samples, just 41% and 74% produced exactly or partially matching host plant identifications, respectively, indicating that different sample types provided complementary information about herbivore diet. Some plant species were more likely to be identified from faecal samples than expected by chance, and we found that this identification bias skewed towards plant species with higher investment in leaf tissue. We conclude that multiple sample types may be required to fully characterise an invertebrate herbivore species' diet.
Analysis of effect of vertical ground shaking in bridges isolated with spherical sliding bearings
Authors: Ryan Keri L. , Mojidra Rushil 
Published: August 2023

AbstractStudies have shown that in structures isolated with spherical sliding bearings, the seismic base shear increases when the vertical component of ground shaking is explicitly considered, since the dynamic variation of bearing axial force is passed on to the base shear due to the friction mechanism. In this paper, the effect of vertical shaking is systematically investigated in multi‐span concrete box‐girder highway bridges isolated with triple pendulum bearings. Grounded in the theory of bearing mechanics, a simplified method to predict the amplification of base shear with vertical ground shaking intensity in such bridges is developed and evaluated. The simplified approach is potentially applicable for bridge design based on equivalent static analysis. At low to moderate vertical intensities, the simplified method can capture the observed variation in the base‐shear coefficient with isolation system parameters. The differences in base‐shear amplification for bridge superstructure parameter variations are insignificant, and thus the method is widely applicable. At high intensity vertical ground shaking, the base shear coefficient can be affected by an uplift and impact phenomenon. Thus, application of the simplified method should be limited to motions with peak vertical acceleration up to 1 g; simulation with 3D motions is recommended for intensities beyond 1 g.
Assessing Contaminants of Emerging Concern in the Great Lakes Ecosystem: A Decade of Method Development and Practical Application
Authors: Ankley Gerald T. , Corsi Steven R. , Custer Christine M. , Ekman Drew R. , Hummel Stephanie L. , Kimbrough Kimani L. , Schoenfuss Heiko L. , Villeneuve Daniel L. 
Published: August 2023

Abstract
Assessing the ecological risk of contaminants in the field typically involves consideration of a complex mixture of compounds which may or may not be detected via instrumental analyses. Further, there are insufficient data to predict the potential biological effects of many detected compounds, leading to their being characterized as contaminants of emerging concern (CECs). Over the past several years, advances in chemistry, toxicology, and bioinformatics have resulted in a variety of concepts and tools that can enhance the pragmatic assessment of the ecological risk of CECs. The present Focus article describes a 10+- year multiagency effort supported through the U.S. Great Lakes Restoration Initiative to assess the occurrence and implications of CECs in the North American Great Lakes. State-of-the-science methods and models were used to evaluate more than 700 sites in about approximately 200 tributaries across lakes Ontario, Erie, Huron, Michigan, and Superior, sometimes on multiple occasions. Studies featured measurement of up to 500 different target analytes in different environmental matrices, coupled with evaluation of biological effects in resident species, animals from in situ and laboratory exposures, and in vitro systems. Experimental taxa included birds, fish, and a variety of invertebrates, and measured endpoints ranged from molecular to apical responses. Data were integrated and evaluated using a diversity of curated knowledgebases and models with the goal of producing actionable insights for risk assessors and managers charged with evaluating and mitigating the effects of CECs in the Great Lakes. This overview is based on research and data captured in approximately about 90 peer-reviewed journal articles and reports, including approximately about 30 appearing in a virtual issue comprised of highlighted papers published in Environmental Toxicology and Chemistry or Integrated Environmental Assessment and Management. Environ Toxicol Chem 2023;42:2506–2518. © 2023 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
The effect of nutrition and health behavior change communication through community‐level actors on the nutritional status of pregnant women in the Ambo district, Ethiopia: A randomized controlled trial
Authors: Gebremichael Mitsiwat Abebe , Belachew Lema Tefera 
Published: August 2023

AbstractPregnant women in Ethiopia often had trouble understanding the normal nutrition and health information given by health professionals and found it inconsistent. Undernutrition is still a significant public health problem as a result. Hence, this trial aimed to assess the effect of nutrition and health behavior change communication using the community‐level actors on the nutritional status of pregnant women. Cluster‐randomized controlled community trial with baseline and endline measurements were used. Endpoint data from 744 pregnant women (372 intervention and 372 control groups) were gathered, respectively. In the intervention group, the community‐level actors delivered the behavior change communication main message based on intervention protocol. The control group got nutrition information during their ANC visits but did not receive the behavior change communication intervention. Binary generalized estimating equations regression analyses adjusted for baseline covariates were used to test effects of the intervention on nutritional status. Following the trial's implementation, the prevalence of undernutrition in the intervention arm fell by 10% from the baseline (23.7% vs. 13.7%) and was 13.7% lower than in the control arm (13.7% vs. 27.4%, p = <.001). Pregnant women in the intervention group showed significantly lower risk of undernutrition than the control group (ARR = 0.21; 95% CI 0.14–0.30). This study showed that engaging community actors to communicate about nutrition and health behavior change was successful in enhancing pregnant women's nutritional status. Therefore, nutrition and health behavior change communication through the community‐level actors is recommended to improve the nutritional status of pregnant women.
A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms
Authors: Daneshvar Siamak , Zamanian Mohammad Yasin , Ivraghi Mehraveh Sadeghi , Golmohammadi Maryam , Modanloo Mona , Kamiab Zahra , Pourhosseini Seyed Mohammad Ebrahim , Heidari Mahsa , Bazmandegan Gholamreza 
Published: August 2023

AbstractColon cancer (CC) is one of the most common and deadly cancers worldwide. Oncologists are facing challenges such as development of drug resistance and lack of suitable drug options for CC treatment. Flavonoids are a group of natural compounds found in fruits, vegetables, and other plant‐based foods. According to research, they have a potential role in the prevention and treatment of cancer. Apigenin is a flavonoid that is present in many fruits and vegetables. It has been used as a natural antioxidant for a long time and has been considered due to its anticancer effects and low toxicity. The results of this review study show that apigenin has potential anticancer effects on CC cells through various mechanisms. In this comprehensive review, we present the cellular targets and signaling pathways of apigenin indicated to date in in vivo and in vitro CC models. Among the most important modulated pathways, Wnt/β‐catenin, PI3K/AKT/mTOR, MAPK/ERK, JNK, STAT3, Bcl‐xL and Mcl‐1, PKM2, and NF‐kB have been described. Furthermore, apigenin suppresses the cell cycle in G2/M phase in CC cells. In CC cells, apigenin‐induced apoptosis is increased by inhibiting the formation of autophagy. According to the results of this study, apigenin appears to have the potential to be a promising agent for CC therapy, but more research is required in the field of pharmacology and pharmacokinetics to establish the apigenin effects and its dosage for clinical studies.