bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Resolution Records of Millennial‐Scale East Asian Winter Monsoon in the Shelf Sea of Eastern China
Authors: Shi Yong , Xu Xiaomei , Yang Guang , Du Jiabi , Lv Jixuan , Zhang Shuo , Liu Shengjing , Liu Tao , Zhang Zhenyu , Gao Shu , Gao Jianhua 
Published: March 2023

AbstractThe evolution of the East Asian winter monsoon (EAWM) during the Holocene remains controversial because of the lack of reliable proxies. In this study, a link between cross‐front transport and the EAWM was found in the North Yellow Sea, and the EAWM intensity could be imprinted in the leaked sediment, which permits reliable reconstruction of the EAWM on well‐preserved offshore deposition. By comparison with instrumental data, the wind speed of the EAWM since 4.4 ka was quantitatively reconstructed for the first time at high resolution (∼5 yr). The results show that the EAWM gradually weakened in the mid‐to‐late Holocene, which was likely controlled by solar insolation, and that there has been a negative relationship between the EAWM and temperature on the centennial scale since ∼2.0 ka; this relationship was reversed by increasing CO2 emissions during the Current Warm Period.
RCM Modeling of Bubble Injections Into the Inner Magnetosphere: Spectral Properties of Plasma Sheet Particles
Authors: Sadeghzadeh Sina , Yang Jian , Toffoletto Frank , Wolf Richard , Mousavi Ameneh , Espinoza C. M. 
Published: March 2023

AbstractCollisionless astrophysical plasmas are correlated systems in which particles are often not in thermal equilibrium and can be characterized by power‐law distributions. The kappa distribution function, which is a more generalized form of the power‐law function, is often used to describe acceleration and production of high‐energy particles in different space plasma environments. The spectra of particles in the Earth's plasma sheet constructed using Time History of Events and Mesoscale Interactions during Substorms data show that the kappa index exhibits a strong dawn‐dusk asymmetry and a clear dependence on both geocentric distance and magnetic local time. Furthermore, statistics indicate that spectrum hardening, or softening is expected during geomagnetically disturbed periods. To understand how the shape of the particle distribution function evolves and what factors affect the kappa index, we simulate earthward plasma transport using a kinetic drift model. In the simulations, the plasma distribution is initially considered to be a kappa function with . However, with time, both protons and electrons' distribution functions evolve and deviate from their initial shapes. We demonstrate that by implementing transient low‐entropy plasma injections, the Rice Convection Model average distribution functions can reasonably agree with observations. We also discuss the relative impact of gradient/curvature drift, particle loss, and bubble injections, based on controlled numerical experiments.
Qualitative Dissolution Modeling of Etch‐Pit Formation on the K‐Feldspar Surface Through Phase‐Field Approach
Authors: Kumar Akash , Prajapati Nishant , Späth Michael , Busch Benjamin , Schneider Daniel , Hilgers Christoph , Nestler Britta 
Published: March 2023

AbstractReservoir quality of sandstones can be controlled by the dissolution of minerals such as K‐feldspar. The present work investigates the impact of dissolution of K‐feldspar (Orthoclase) on the resulting porosity and permeability of sandstones using a thermodynamically consistent multiphase‐field model. Two novel aspects of this research are: (a) identification and calibration of interfacial surface energy and kinetics related model parameters based on existing literature, to account for the formation and growth of diamond‐shaped etch‐pits during dissolution, and (b) the workflow for three‐dimensional modeling of dissolution at sub‐micrometer scale within individual feldspar grains, followed by up‐scaling the phenomenon to a multigrain pack analogous to sandstone. The simulated dissolution, when visualized in the relevant planes, show clear similarities with microphotographs of natural samples and previous numerical works, in terms of facet‐formation and merging of the etch‐pit morphologies. For the computation of permeability, computational fluid dynamics analysis was performed for grain packs at different stages of dissolution. Finally, the generated data‐sets were analyzed to study the impact of rock properties including a fraction of feldspar grains and their crystallographic orientation on the porosity, permeability and their correlations, for sandstones undergoing K‐feldspar dissolution. At the same porosity, sandstones containing a greater proportion of K‐feldspar grains are expected to have greater permeabilities. The devised workflow for model calibration and up‐scaling complimented by the innovative post‐processing and visualization techniques can be adapted to study dissolution of other minerals in different rocks.
Influence of Viscous Lubricant on Nucleation and Propagation of Frictional Ruptures
Authors: Paglialunga F. , Passelègue F. , Latour S. , Gounon A. , Violay M. 
Published: March 2023

AbstractFluids are pervasive in the Earth's crust and saturate fractures and faults. The combination of fluids and gouge layers developing along faults can generate fluids of different viscosities. Such viscous fluids were found to influence the reactivation, frictional stability of faults, and eventually the dynamics of propagating earthquake ruptures. We reproduced laboratory earthquakes on analog material (PMMA) to study the influence of viscous lubricant on fault frictional stability, rupture nucleation, and propagation under mixed lubrication conditions. Experiments were conducted in dry conditions, and with fluids presenting a viscosity ranging from 1 to 1,000 mPa.s. Through photoelasticity, high‐frequency strain gauge sensors, and accelerometer measurements, we obtained new insights about the influence of lubricant on a characteristic nucleation length, rupture propagation velocity, and local slip and slip rate evolution during the reproduced frictional ruptures. Our experiments show that the presence of a lubricant generating mixed lubricated conditions along the fault induces, (a) a reduction of the frictional resistance, (b) an increase in nucleation length, (c) a decrease in the fracture energy. In addition, the larger the viscosity of the fluids, the larger the reduction of frictional strength and the increase in the nucleation length. Moreover, ruptures occurring under mixed lubricated conditions showed a pulse‐like rather than crack‐like behavior, suggesting that viscous lubrication can induce the transition from crack‐like to pulse‐like rupture along natural faults. We demonstrate, supported by existing theory, that this transition is mainly governed by the stress acting on the fault at the onset of nucleation, which is drastically reduced in presence of a lubricant.
How Well Does 4‐km WRF Model Predict Three‐Dimensional Reflectivity Structure Over China as Compared to Radar Observations?
Authors: Zhu Kefeng , Xue Ming , Yang Nan , Zhang Chenyue 
Published: March 2023

AbstractThe performance of 4‐km Weather Research and Forecasting model in predicting reflectivity structure in China over three summer months is investigated using three‐dimensional (3D) reflectivity observations. Three verification domains, namely Southern China (SC), Central and Eastern China , and North China, that correspond to the three major rainfall centers of mainland China are selected. Results show that the forecasts reproduce the distribution and diurnal variation of precipitation well, but significant differences exist in the vertical distributions of the predicted and observed reflectivities. In observations, the highest frequency (of reflectivity ≥35 dBZ) occurs between 3 and 6 km, whereas it is at the surface in the forecast. The forecasts tend to over‐predict reflectivity intensity at the lower levels, especially in SC. Further evaluation using object‐based verification methods show that the forecasts greatly underestimate the afternoon peak frequency of precipitation clouds with reflectivity >30 dBZ. The forecasts fail to reproduce the diurnal variation of 35 dBZ mean and maximum height of the objects, producing less variation than observations. Analyses show that the failure in properly reproducing small‐scale reflectivity objects (with diameter <100 km) is primarily responsible for the underestimation of the mean and maximum object heights. Evaluation using additional 3D information show that the forecasts tend to produce a greater proportion of faster‐moving small‐scale objects. This study reveals that the simulation of the 3D structure of precipitation clouds in terms of reflectivity remains a great challenge, especially for smaller convective cells.
The Climate Response to the Mt. Pinatubo Eruption Does Not Constrain Climate Sensitivity
Authors: Pauling Andrew G. , Bitz Cecilia M. , Armour Kyle C. 
Published: March 2023

AbstractThe climate response to the Mt. Pinatubo volcanic eruption is analyzed using large ensembles of Coupled Model Intercomparison Project Phase 6 (CMIP6) historical simulations. In contrast to previous work, we find that standard measures of the global temperature response to volcanic forcing are not significantly correlated with climate sensitivity across models. Isolating the shortwave response due to non‐cloud effects does not improve the correlation with climate sensitivity. Earlier constraints on climate sensitivity based on the response to Mt. Pinatubo are consistent with having arisen by chance because of the small size of the ensembles used. Our results suggest that the response to Mt. Pinatubo cannot be used to constrain the climate sensitivity to increased greenhouse gas concentrations, as has been proposed, because the radiative feedbacks in response to volcanic eruptions are not well correlated with the feedbacks governing the long‐term response to greenhouse gas forcing.
circPTPN12 promotes the progression and sunitinib resistance of renal cancer via hnRNPM/IL-6/STAT3 pathway
Authors: Shou Yi , Yue Changjie , Wang Qi , Liu Jingchong , Xu Jiaju , Miao Qi , Liu Di , Yang Hongmei , Liu Yuenan , Zhang Xiaoping 
Published: March 2023

AbstractRenal cell carcinoma (RCC) is characterized by the difficulties in early diagnosis and the propensity to metastases. For advanced RCC, sunitinib targeted therapy is the clinically recommended first-line drug and the major challenge of sunitinib treatment is adaptive resistance. Therefore, it is imperative to research the mechanisms underlying sunitinib resistance. In this study, we discovered that circPTPN12 was highly expressed in RCC tissues and was associated with poorer clinical outcomes. circPTPN12 could promote the proliferation, migration, invasion, and sunitinib resistance of RCC cells. Mechanistically, circPTPN12 was found to form a complex with hnRNPM, which was involved in the regulation of mRNA processing. The combination with circPTPN12 enhanced the ability of hnRNPM to maintain the stability of IL-6 mRNA and further activated the STAT3 signaling pathway. The study revealed that circPTPN12/hnRNPM/IL-6/STAT3 axis promoted RCC progression and sunitinib resistance, which might be a promising therapeutic target for relieving sunitinib resistance in RCC.
USP18 is an essential regulator of muscle cell differentiation and maturation
Authors: Olie Cyriel Sebastiaan , Pinto-Fernández Adán , Damianou Andreas , Vendrell Iolanda , Mei Hailiang , den Hamer Bianca , van der Wal Erik , de Greef Jessica C. , Raz Vered , Kessler Benedikt M. 
Published: March 2023

AbstractThe ubiquitin proteasomal system is a critical regulator of muscle physiology, and impaired UPS is key in many muscle pathologies. Yet, little is known about the function of deubiquitinating enzymes (DUBs) in the muscle cell context. We performed a genetic screen to identify DUBs as potential regulators of muscle cell differentiation. Surprisingly, we observed that the depletion of ubiquitin-specific protease 18 (USP18) affected the differentiation of muscle cells. USP18 depletion first stimulated differentiation initiation. Later, during differentiation, the absence of USP18 expression abrogated myotube maintenance. USP18 enzymatic function typically attenuates the immune response by removing interferon-stimulated gene 15 (ISG15) from protein substrates. However, in muscle cells, we found that USP18, predominantly nuclear, regulates differentiation independent of ISG15 and the ISG response. Exploring the pattern of RNA expression profiles and protein networks whose levels depend on USP18 expression, we found that differentiation initiation was concomitant with reduced expression of the cell-cycle gene network and altered expression of myogenic transcription (co) factors. We show that USP18 depletion altered the calcium channel gene network, resulting in reduced calcium flux in myotubes. Additionally, we show that reduced expression of sarcomeric proteins in the USP18 proteome was consistent with reduced contractile force in an engineered muscle model. Our results revealed nuclear USP18 as a critical regulator of differentiation initiation and maintenance, independent of ISG15 and its role in the ISG response.
Nodal promotes colorectal cancer survival and metastasis through regulating SCD1-mediated ferroptosis resistance
Authors: Wu Tianqi , Wan Jian , Qu Xiao , Xia Kai , Wang Fangtao , Zhang Zichao , Yang Muqing , Wu Xiaocai , Gao Renyuan , Yuan Xiaoqi , Fang Lin , Chen Chunqiu , Yin Lu 
Published: March 2023

AbstractRe-expression of an embryonic morphogen, Nodal, has been seen in several types of malignant tumours. By far, studies about Nodal’s role in colorectal cancer (CRC) remain limited. Ferroptosis is essential for CRC progression, which is caused by cellular redox imbalance and characterized by lipid peroxidation. Herein, we observed that Nodal enhanced CRC cell’s proliferative rate, motility, invasiveness, and epithelial–mesenchymal transition (EMT) in vivo and in vitro. Notably, Nodal overexpression induced monounsaturated fatty acids synthesis and increased the lipid unsaturation level. Nodal knockdown resulted in increased CRC cell lipid peroxidation. Stearoyl-coenzyme A desaturase 1 (SCD1) inhibition at least partially abolished the resistance of Nodal-overexpressing cells to RSL3-induced ferroptosis. Mechanistically, SCD1 was transcriptionally up-regulated by Smad2/3 pathway activation in response to Nodal overexpression. Significant Nodal and SCD1 up-regulation were observed in CRC tissues and were associated with CRC metastasis and poor clinical outcomes. Furthermore, bovine serum albumin nanoparticles/si-Nodal nanocomplexes targeting Nodal had anti-tumour effects on CRC progression and metastasis. This research elucidated the role of Nodal in CRC development and revealed a potential gene-based therapeutic strategy targeting Nodal for improving CRC treatment.
Bioelectrocatalysis with a palladium membrane reactor
Authors: Kurimoto Aiko , Nasseri Seyed A. , Hunt Camden , Rooney Mike , Dvorak David J. , LeSage Natalie E. , Jansonius Ryan P. , Withers Stephen G. , Berlinguette Curtis P. 
Published: March 2023

AbstractEnzyme catalysis is used to generate approximately 50,000 tons of value-added chemical products per year. Nearly a quarter of this production requires a stoichiometric cofactor such as NAD+/NADH. Given that NADH is expensive, it would be beneficial to regenerate it in a way that does not interfere with the enzymatic reaction. Water electrolysis could provide the proton and electron equivalent necessary to electrocatalytically convert NAD+to NADH. However, this form of electrocatalytic NADH regeneration is challenged by the formation of inactive NAD2dimers, the use of high overpotentials or mediators, and the long-term electrochemical instability of the enzyme during electrolysis. Here, we show a means of overcoming these challenges by using a bioelectrocatalytic palladium membrane reactor for electrochemical NADH regeneration from NAD+. This achievement is possible because the membrane reactor regenerates NADH through reaction of hydride with NAD+in a compartment separated from the electrolysis compartment by a hydrogen-permselective Pd membrane. This separation of the enzymatic and electrolytic processes bypasses radical-induced NAD+degradation and enables the operator to optimize conditions for the enzymatic reaction independent of the water electrolysis. This architecture, which mechanistic studies reveal utilizes hydride sourced from water, provides an opportunity for enzyme catalysis to be driven by clean electricity where the major waste product is oxygen gas.
Electron transfer rules of minerals under pressure informed by machine learning
Authors: Li Yanzhang , Wang Hongyu , Li Yan , Ye Huan , Zhang Yanan , Yin Rongzhang , Jia Haoning , Hou Bingxu , Wang Changqiu , Ding Hongrui , Bai Xiangzhi , Lu Anhuai 
Published: March 2023

AbstractElectron transfer is the most elementary process in nature, but the existing electron transfer rules are seldom applied to high-pressure situations, such as in the deep Earth. Here we show a deep learning model to obtain the electronegativity of 96 elements under arbitrary pressure, and a regressed unified formula to quantify its relationship with pressure and electronic configuration. The relative work function of minerals is further predicted by electronegativity, presenting a decreasing trend with pressure because of pressure-induced electron delocalization. Using the work function as the case study of electronegativity, it reveals that the driving force behind directional electron transfer results from the enlarged work function difference between compounds with pressure. This well explains the deep high-conductivity anomalies, and helps discover the redox reactivity between widespread Fe(II)-bearing minerals and water during ongoing subduction. Our results give an insight into the fundamental physicochemical properties of elements and their compounds under pressure.
Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry
Authors: Watanabe Kanako , Oka Tomoichiro , Takagi Hirotaka , Anisimov Sergei , Yamashita Shun-ichi , Katsuragi Yoshinori , Takahashi Masahiko , Higuchi Masaya , Kanki Tomotake , Saitoh Akihiko , Fujii Masahiro 
Published: March 2023

AbstractHuman parechovirus (PeV-A) is an RNA virus that belongs to the family Picornaviridae and it is currently classified into 19 genotypes. PeV-As usually cause mild illness in children and adults. Among the genotypes, PeV-A3 can cause severe diseases in neonates and young infants, resulting in neurological sequelae and death. In this study, we identify the human myeloid-associated differentiation marker (MYADM) as an essential host factor for the entry of six PeV-As (PeV-A1 to PeV-A6), including PeV-A3. The infection of six PeV-As (PeV-A1 to PeV-A6) to human cells is abolished by knocking out the expression of MYADM. Hamster BHK-21 cells are resistant to PeV-A infection, but the expression of human MYADM in BHK-21 confers PeV-A infection and viral production. Furthermore, VP0 capsid protein of PeV-A3 interacts with one extracellular domain of human MYADM on the cell membrane of BHK-21. The identification of MYADM as an essential entry factor for PeV-As infection is expected to advance our understanding of the pathogenesis of PeV-As.
Spinful hinge states in the higher-order topological insulators WTe2
Authors: Lee Jekwan , Kwon Jaehyeon , Lee Eunho , Park Jiwon , Cha Soonyoung , Watanabe Kenji , Taniguchi Takashi , Jo Moon-Ho , Choi Hyunyong 
Published: March 2023

AbstractHigher-order topological insulators are recently discovered quantum materials exhibiting distinct topological phases with the generalized bulk-boundary correspondence. Td-WTe2 is a promising candidate to reveal topological hinge excitation in an atomically thin regime. However, with initial theories and experiments focusing on localized one-dimensional conductance only, no experimental reports exist on how the spin orientations are distributed over the helical hinges—this is critical, yet one missing puzzle. Here, we employ the magneto-optic Kerr effect to visualize the spinful characteristics of the hinge states in a few-layer Td-WTe2. By examining the spin polarization of electrons injected from WTe2 to graphene under external electric and magnetic fields, we conclude that WTe2 hosts a spinful and helical topological hinge state protected by the time-reversal symmetry. Our experiment provides a fertile diagnosis to investigate the topologically protected gapless hinge states, and may call for new theoretical studies to extend the previous spinless model.
Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma
Authors: Chung Jeff Yat-Fai , Tang Philip Chiu-Tsun , Chan Max Kam-Kwan , Xue Vivian Weiwen , Huang Xiao-Ru , Ng Calvin Sze-Hang , Zhang Dongmei , Leung Kam-Tong , Wong Chun-Kwok , Lee Tin-Lap , Lam Eric W-F , Nikolic-Paterson David J. , To Ka-Fai , Lan Hui-Yao , Tang Patrick Ming-Kuen 
Published: March 2023

AbstractNeutrophils are dynamic with their phenotype and function shaped by the microenvironment, such as the N1 antitumor and N2 pro-tumor states within the tumor microenvironment (TME), but its regulation remains undefined. Here we examine TGF-β1/Smad3 signaling in tumor-associated neutrophils (TANs) in non-small cell lung carcinoma (NSCLC) patients. Smad3 activation in N2 TANs is negatively correlate with the N1 population and patient survival. In experimental lung carcinoma, TANs switch from a predominant N2 state in wild-type mice to an N1 state in Smad3-KO mice which associate with enhanced neutrophil infiltration and tumor regression. Neutrophil depletion abrogates the N1 anticancer phenotype in Smad3-KO mice, while adoptive transfer of Smad3-KO neutrophils reproduces this protective effect in wild-type mice. Single-cell analysis uncovers a TAN subset showing a mature N1 phenotype in Smad3-KO TME, whereas wild-type TANs mainly retain an immature N2 state due to Smad3. Mechanistically, TME-induced Smad3 target genes related to cell fate determination to preserve the N2 state of TAN. Importantly, genetic deletion and pharmaceutical inhibition of Smad3 enhance the anticancer capacity of neutrophils against NSCLC via promoting their N1 maturation. Thus, our work suggests that Smad3 signaling in neutrophils may represent a therapeutic target for cancer immunotherapy.
A mass spectrum-oriented computational method for ion mobility-resolved untargeted metabolomics
Authors: Luo Mingdu , Yin Yandong , Zhou Zhiwei , Zhang Haosong , Chen Xi , Wang Hongmiao , Zhu Zheng-Jiang 
Published: March 2023

AbstractIon mobility (IM) adds a new dimension to liquid chromatography-mass spectrometry-based untargeted metabolomics which significantly enhances coverage, sensitivity, and resolving power for analyzing the metabolome, particularly metabolite isomers. However, the high dimensionality of IM-resolved metabolomics data presents a great challenge to data processing, restricting its widespread applications. Here, we develop a mass spectrum-oriented bottom-up assembly algorithm for IM-resolved metabolomics that utilizes mass spectra to assemble four-dimensional peaks in a reverse order of multidimensional separation. We further develop the end-to-end computational framework Met4DX for peak detection, quantification and identification of metabolites in IM-resolved metabolomics. Benchmarking and validation of Met4DX demonstrates superior performance compared to existing tools with regard to coverage, sensitivity, peak fidelity and quantification precision. Importantly, Met4DX successfully detects and differentiates co-eluted metabolite isomers with small differences in the chromatographic and IM dimensions. Together, Met4DX advances metabolite discovery in biological organisms by deciphering the complex 4D metabolomics data.