bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of primary patella resurfacing on health-related quality of life outcomes and return to sport in total knee arthroplasty (TKA)
Authors: Schatz Caroline , Plötz Werner , Beckmann Johannes , Leidl Reiner , Buschner Peter 
Published: June 2023

Abstract
Introduction
Primary patella resurfacing (PPR) in primary total knee arthroplasty (TKA) is a topic without clear clinical evidence. Using Patient Reported Outcome Measurements (PROM), previous work found TKA patients without PPR to have more pain postoperatively, but little is known whether this may impede patients from returning to their usual leisure sport. This observational study aimed at evaluating the treatment effect of PPR, with PROMs and return to sport (RTS).

Materials and methods
156 primary TKA patients were retrospectively included from August 2019 to November 2020, from a single hospital in Germany. PROMs were measured with the Western Ontario McMaster University Osteoarthritis Index (WOMAC) and the EuroQoL Visual Analog Scale (EQ-VAS), preoperatively and 1 year postoperatively. Leisure sport with three levels of intensity (never, sometimes, regular) were requested. The treatment effect of PPR was evaluated with a difference-in-difference (DiD) approach, with several confounders.

Results
Descriptively, the mean WOMAC total score and the mean WOMAC pain score were postoperatively better with PPR, ( – 4.8 points,  – 1.1 points), then without PPR. The mean improvements of the WOMAC total score were better with PPR ( – 7.8 points). Mean improvements for the WOMAC pain score were also better with PPR ( – 1.2 points). Mean EQ-VAS were postoperatively similar, and the mean improvements were better with PPR (3.4 points). Rate of RTS was 93% for patients with PPR and 95% for patients without PPR. The DiD revealed minor differences in PROMs and RTS, not to result in statistically significant treatment effects.

Conclusions
There was no treatment effect for TKA with PPR, regarding PROMs and RTS, and descriptive differences were below published thresholds for clinical relevance. Rate of RTS was high for all patients, regardless of PPR. For the two endpoint categories, there was no measurable advantage of TKA with PPR over TKA without PPR.
Grundlagenuntersuchungen für die Revitalisierung und Erneuerung von Kieslaichplätzen in alpinen Fließgewässern
Authors: Holzapfel Patrick , Schähle Zacharias , Schletterer Martin , Hauer Christoph 
Published: June 2023

ZusammenfassungDie erfolgreiche Etablierung vitaler, sich selbst erhaltender Fischpopulationen in Fließgewässern hängt wesentlich von geeigneten Lebensraumbedingungen für alle Altersstadien der vorkommenden Arten ab. Die Europäische Äsche (Thymallus thymallus) ist eine Salmoniden-Fischart, die in vielen europäischen Ländern aufgrund ihres massiven Rückgangs hinsichtlich Abundanz und Biomasse als gefährdet gilt. Ursächlich ist dies vor allem auf menschliche Eingriffe in den Lebensraum durch Gewässerregulierungen zurückzuführen. Zudem ist das Vorhandensein von kiesigem Sohlsubstrat besonders wichtig für die erfolgreiche Reproduktion von Salmoniden, da diese ihre Eier aktiv in den Schotterkörper einbringen und dort eine ausreichende Versorgung mit Sauerstoff benötigen. Laichhabitate sind daher für Äschen und andere Salmoniden als entscheidende und kritische Lebensräume zu betrachten und können bei entsprechendem Mangel populationslimitierend wirken. Das Ziel des vorliegenden Artikels besteht darin, erstmals eine vergleichende ökohydraulische Analyse von Laichplätzen der Äsche in alpinen Flusssystemen durchzuführen. Dabei wurde die Situation der Laichplätze hinsichtlich hydraulischer und sedimentologischer Kriterien bewertet und es wurden Analysen der potenziellen Laichplätze für verschiedene Untersuchungsstrecken mit stark unterschiedlichen Einzugsgebieten, Fließgewässerordnungen und Typologien durchgeführt. Die daraus gewonnenen Erkenntnisse sollen als Grundlage für zukünftige Revitalisierungsprojekte dienen, die Fließgewässer unterschiedlicher Typologien und Größenordnungen im Zuge von erforderlichen Sanierungen betreffen können.
Solubility equilibria in the ternary systems Rb2SO4 – CaSO4 – H2O and Cs2SO4 – CaSO4 – H2O at ambient temperature, and the crystal structure of rubidium syngenite
Authors: Freyer Daniela , Losch Grit , Pannach Melanie , Sohr Julia 
Published: June 2023

AbstractFor the ternary systems, Rb2SO4 – CaSO4 – H2O and Cs2SO4 – CaSO4 – H2O, solubility data have been determined at ambient temperatures (22 and 25 °C). In both systems, gypsum is found as the stable CaSO4-phase in the presence of low alkali metal sulfate concentrations. In addition, two double salts exist in the Rb-system: Rb-disalt (Rb2SO4·2CaSO4) and Rb-syngenite (Rb2SO4·CaSO4·H2O) in addition to gypsum and Rb2SO4. For Rb-syngenite, the crystal structure was determined by single crystal structure analysis (space group P21/m(11), a = 6.323 Å, b = 7.223 Å, c = 10.044 Å, β = 102.96°, Z = 2, V = 447.03 Å3), which is isomorphous to potassium syngenite (K2SO4·CaSO4·H2O). In the Cs-system, besides gypsum and Cs2SO4, only the double salt Cs2SO4·2CaSO4 exists.
Graphical abstract
From stone to silicon: technical advances in epigraphy
Authors: Seales W. Brent , Chapman Christy Y. 
Published: June 2023

AbstractThrough the annals of time, writing has slowly scrawled its way from the painted surfaces of stone walls to the grooves of inscriptions to the strokes of quill, pen, and ink. While we still inscribe stone (tombstones, monuments) and we continue to write on skin (tattoos abound), our quotidian method of writing on paper is increasingly abandoned in favor of the quick-to-generate digital text. And even though the stone-inscribed text of epigraphy offers demonstrably better permanence than that of writing on skin and paper—even better than that of the memory system of the modern computer (Bollacker in Am Sci 98:106, 2010)—this field of study has also made the digital leap. Today’s scholarly analyses of epigraphic content increasingly rely on high-tech approaches involving data science and computer models. This essay discusses how advances in a number of exciting technologies are enabling the digital analysis of epigraphic texts and accelerating the ability of scholars to preserve, renew, and reinvigorate the study of the inscriptions that remain from throughout history.
Multicommodity network flow model of a human resource allocation problem considering time periods
Authors: Ercsey Zsolt , Kovács Zoltán 
Published: June 2023

AbstractThis article addresses the problem of finding work assignments for employees within a given time horizon in a company using a multicommodity network flow model. The problem of human resource allocation is defined by the actual manpower demands of different periods which may vary during different periods. The investigation focuses on when workers should be called in-house and for how long to satisfy demands, while also complying with labour standards and regulations. Additional targets may also be set up, such as minimising the overall number of labour, as well as meeting “comfort” expectations, i.e. the most even working time should be realised for every worker within the event horizon. The paper describes how the multicommodity network flow model is constructed and the corresponding MILP mathematical programming model is formulated in a simple situation where there is only one position for the labour. Finally, the article explains how to construct the multicommodity network flow model and the MILP model for the general case, where there are multiple positions for the labour requiring various skills and competences per position within the periods.
Levelling Up for health in towns? Development of a new deprivation index: the ‘Stronger Towns Index’ and its association with self-rated health and migration in England, between 2001 and 2011
Authors: Duke-Williams Oliver , Stockton Jemima , Shelton Nicola 
Published: June 2023

Abstract
Aim
To develop the ‘Stronger Towns Index': a deprivation index that took into account characteristics of areas encompassing towns that may be eligible for redevelopment funding and explore how this index was associated with self-rated health and migration within England between 2001 and 2011.

Subject and methods
All members of the ONS Longitudinal Study in England aged 16 and over in 2001 whose records included a self-rated health response and a valid local authority code.
Local authorities in England were ranked using a composite index developed using the five metrics set out in the Stronger Towns Funding: productivity, income, skills, deprivation measures, and the proportion of people living in towns.
The index was split into deciles, and logistic regression carried out on the association between decile and self-rated health in 2001 in the main sample (n = 407,878) and decile change and self-rated health in 2011 in a subsample also present in 2011, with migration information (n = 299,008).

Results
There were areas in the lowest deciles of Town Strength who did not receive funding. After multiple adjustment, LS members living in areas with higher deciles were significantly more likely (7% to 38%) to report good health than those in the lowest decile in 2001. Remaining in the same decile between 2001 and 2011 was associated with 7% lower odds of good self-rated health in 2011.

Conclusion
It is important to consider health in towns when allocating funding. Areas in the Midlands may have missed out on funding which might help mitigate poor health.
High relative humidity and temperature limit disease development and mortality in golden frogs of Panama, Atelopus zeteki, infected with Batrachochytrium dendrobatidis
Authors: Gass Jordan , Miller Abigail J. , Sheets Ciara , Long Morgan , Voyles Jamie 
Published: June 2023

AbstractTo combat the loss of species due to emerging infectious diseases, scientists must incorporate ecological parameters, such as temperature and humidity, to understand how the environment affects host–pathogen interactions. The fungal disease chytridiomycosis is a compelling case study to investigate the role of both temperature and humidity on infectious disease, as both the fungal pathogen (Batrachochytrium dendrobatidis, Bd) and the host (amphibians) are heavily influenced by these abiotic factors. We performed two experiments to investigate the importance of relative humidity and temperature on frog immunity (production of antimicrobial skin secretions) and disease development in captive golden frogs (Atelopus zeteki) of Panama. We found that the quantity of skin secretions significantly decreased over time in frogs moved from low to medium and high relative humidity treatments. Following Bd exposure, frogs in high temperature (26–27 °C) and high relative humidity (80–90%) had lower pathogen loads and survived significantly longer than frogs kept in all other treatment conditions, including high temperature and low relative humidity. These results suggest that high relative humidity may be an important, although less understood, mediator of Bd infection and the survival of golden frogs. Because the environment can drastically alter disease dynamics, understanding how temperature and humidity influence chytridiomycosis outcomes in golden frogs may be essential for the success of the reintroduction of captive frogs.
Unanimity or standing aside? Reinterpreting consensus in United Nations Framework Convention on Climate Change negotiations
Authors: Rietig Katharina , Peringer Christine , Theys Sarina , Censoro Jecel 
Published: June 2023

AbstractWhat is the meaning of ‘consensus’ within and beyond the UNFCCC? What alternative interpretations of consensus are available based on consensus facilitation practice and related literature? This article assesses the mismatch between how the UNFCCC interprets consensus and its broader interpretation in the facilitation practice literature, and proposes a way forward using the concept of ‘standing aside’ more prominently. The restrictive consensus interpretation has far-reaching implications for the ability of the world’s central climate regime to be fit for purpose, i.e., facilitating multilateral climate action. The analysis of consensus in the UNFCCC points to the central problems of unpredictability and ambiguity in the determination that consensus exists. Many negotiators and chairs acknowledge the problem of predominantly interpreting consensus as unanimity and have subsequently sought ways to address the damage it does through ad hoc rulings that consensus exists sometimes by ignoring the expressions of objection; however, this comes at the expense of a good predictable process.
“The peripheral perfusion index discriminates haemodynamic responses to induction of general anaesthesia”
Authors: Højlund Jakob , Petersen David René , Agerskov Marianne , Foss Nicolai Bang 
Published: June 2023

AbstractInduction of general anaesthesia is often accompanied by hypotension. Standard haemodynamic monitoring during anaesthesia relies on intermittent blood pressure and heart rate. Continuous monitoring systemic blood pressure requires invasive or advanced modalities creating a barrier for obtaining important information of the circulation. The Peripheral Perfusion Index (PPI) is obtained non-invasively and continuously by standard photoplethysmography. We hypothesized that different patterns of changes in systemic haemodynamics during induction of general anaesthesia would be reflected in the PPI. Continuous values of PPI, stroke volume (SV), cardiac output (CO), and mean arterial pressure (MAP) were evaluated in 107 patients by either minimally invasive or non-invasive means in a mixed population of surgical patients. 2 min after induction of general anaesthesia relative changes of SV, CO, and MAP was compared to the relative changes of PPI. After induction total cohort mean(± st.dev.) MAP, SV, and CO decreased to 65(± 16)%, 74(± 18)%, and 63(± 16)% of baseline values. In the 38 patients where PPI decreased MAP was 57(± 14)%, SV was 63(± 18)%, and CO was 55(± 18)% of baseline values 2 min after induction. In the 69 patients where PPI increased the corresponding values were MAP 70(± 15)%, SV 80(± 16)%, and CO 68(± 17)% (all differences: p < 0,001). During induction of general anaesthesia changes in PPI discriminated between the degrees of reduction in blood pressure and algorithm derived cardiac stroke volume and -output. As such, the PPI has potential to be a simple and non-invasive indicator of the degree of post-induction haemodynamic changes.
Knowledge, Attitudes, and Behaviours Concerning the Mediterranean Diet Among Older Adults in Australia
Authors: Turner Ashlee , LaMonica Haley M , Moroney Carissa , O’Leary Fiona , Naismith Sharon L , Flood Victoria M 
Published: June 2023

AbstractDespite the growing body of evidence demonstrating the positive health effects of the Mediterranean diet, it is not routinely recommended in practice and adherence is low in the general population in Australia. The knowledge-attitude-behaviour model explains how health behaviours are supported through a process of acquiring knowledge, developing attitudes, and forming behaviours. Evidence has suggested that having a high level of nutrition-related knowledge is associated with more positive attitudes, which is directly linked to positive dietary behaviours. However, reports of knowledge and attitudes towards the Mediterranean diet, and how these directly relate to behaviours in older adults, are lacking. This study explored Mediterranean diet-related knowledge, attitudes, and behaviours among community-dwelling older adults in Australia. Participants were adults aged 55 years and older who completed an online survey that contained three parts: (a) knowledge – Mediterranean Diet Nutrition Knowledge Questionnaire (Med-NKQ); (b) nutrition-related attitudes and behaviours, and barriers and enablers to dietary change; (c) demographics. The sample included 61 adults who ranged in age from 55 to 89 years. The overall knowledge score was 30.5 out of a possible 40 points, with 60.7% classified as having a high level of knowledge. Knowledge was lowest for nutrient content and label reading. Attitudes and behaviours were generally positive and were not associated with level of knowledge. The most common barriers to dietary change were perceived cost and lack of knowledge, and motivational factors. There are a number of key gaps in knowledge that should be addressed through targeted educational programs. Strategies and tools to overcome perceived barriers and improve self-efficacy are needed to facilitate positive dietary behaviours.
Treatment benefit in patients aged 80 years or older with biopsy-proven and non-resected glioblastoma is dependent on MGMT promoter methylation status
Authors: Weller Jonathan , Katzendobler Sophie , Niedermeyer Sebastian , Harter Patrick N. , Herms Jochen , Trumm Christoph , Niyazi Maximilian , Thon Niklas , Tonn Joerg-Christian , Stoecklein Veit M. 
Published: June 2023

Abstract
Purpose
Glioblastoma is associated with especially poor outcome in the elderly. It is unclear if patients aged ≥80 years benefit from tumor-specific therapy as opposed to receiving best supportive care (BSC) only.

Methods
Patients with IDH-wildtype glioblastoma (WHO 2021), aged ≥80 years, and diagnosed by biopsy between 2010 and 2022 were included. Patient characteristics and clinical parameters were assessed. Uni- and multivariate analyses were performed.

Results
76 patients with a median age of 82 (range 80–89) and a median initial KPS of 80 (range 50–90) were included. Tumor-specific therapy was initiated in 52 patients (68%). 22 patients (29%) received temozolomide monotherapy, 23 patients (30%) were treated with radiotherapy (RT) alone and 7 patients (9%) received combination therapies. In 24 patients (32%), tumor-specific therapy was omitted in lieu of BSC. Overall survival (OS) was longer in patients receiving tumor-specific therapy (5.4 vs. 3.3 months, p < 0.001). Molecular stratification showed that the survival benefit was owed to patients with MGMT promoter methylation (MGMTpos) who received tumor-specific therapy as opposed to BSC (6.2 vs. 2.6 months, p < 0.001), especially to those with better clinical status and no initial polypharmacy. Patients with unmethylated MGMT promoter (MGMTneg) did not benefit from tumor-specific therapy (3.6 vs. 3.7 months, p = 0.18). In multivariate analyses, better clinical status and MGMT promoter methylation were associated with prolonged survival (p < 0.01 and p = 0.01).

Conclusion
Benefit from tumor-specific treatment in patients with newly diagnosed glioblastoma aged ≥80 years might be restricted to MGMTpos patients, especially to those with good clinical status and no polypharmacy.
Algorithmic differentiation and hull-consistency enforcing using C++ template meta-programming
Authors: Kubica Bartłomiej Jacek 
Published: June 2023

AbstractAlgorithmic differentiation is a tool used in several branches of computational science, both in conjunction with the interval calculus, and apart of it. This paper presents the ADHC library [14] developed by the author, and identified as package “na60” byNumerical Algorithmsjournal. This library makes intensive use of the C++ template meta-programming, and it has several unique features. ADHC seems particularly useful for interval-related applications. The library has been used by some solvers, also developed by the author, including HIBA_USNE. The paper describes the library, presenting its features, focusing on the new ones, added in version 2.0; in particular, we describe bounding subdifferentials of non-smooth functions and computing derivatives over various datatypes. Efficiency comparison with respect to other packages is also presented. Then some examples of ADHC applications are given, involving the use of HIBA_USNE and standard benchmark problems for solving nonlinear systems. A particular emphasis is put on examples related to modern machine learning, but not limited to them. Planned extensions and possible directions for future development of ADHC are also outlined and discussed.
A longitudinal intervention study of the effects of increasing amount of meaningful writing across grades 1 and 2
Authors: Skar Gustaf B. , Graham Steve , Huebner Alan , Kvistad Anne Holten , Johansen Marita Byberg , Aasen Arne Johannes 
Published: June 2023

AbstractThe current study examined the effectiveness of a writing is caught approach with young developing writers in Norway. This method is based on the premise that writing competence is acquired naturally through real use in meaningful contexts. Our longitudinal randomized control trial study tested this proposition by examining if increasing first grade students’ opportunities to write in various genres for different purposes and for a range of audiences over a two-year time period improved the quality of their writing, handwriting fluency, and attitude towards writing. The study included data from 942 students (50.1% girls) in 26 schools randomly assigned to the experimental treatment, and 743 students (50.6% girls) in 25 schools randomly assigned to the business-as-usual (BAU) control condition. Across Grades 1 and 2, experimental teachers were asked to supplement their typical writing instruction by implementing 40 writing activities designed to increase students’ purposeful writing. Increasing experimental students’ writing over the two-year period did not result in statistically detectable differences in the writing quality, handwriting fluency, and attitude towards writing of students in the experimental and BAU control conditions. These findings did not provide support for the effectiveness of the writing is caught approach. Implications for theory, research, and practiced are discussed.
MetaPro: a web-based metabolomics application for LC-MS data batch inspection and library curation
Authors: An Shaowei , Wang Ruimin , Lu Miaoshan , Zhang Chao , Liu Huafen , Wang Jinyin , Xie Cong , Yu Changbin 
Published: June 2023

Abstract
Introduction
Metabolomics analysis based on liquid chromatography-mass spectrometry (LC-MS) has been a prevalent method in the metabolic field. However, accurately quantifying all the metabolites in large metabolomics sample cohorts is challenging. The analysis efficiency is restricted by the abilities of software in many labs, and the lack of spectra for some metabolites also hinders metabolite identification.

Objectives
Develop software that performs semi-targeted metabolomics analysis with an optimized workflow to improve quantification accuracy. The software also supports web-based technologies and increases laboratory analysis efficiency. A spectral curation function is provided to promote the prosperity of homemade MS/MS spectral libraries in the metabolomics community.

Methods
MetaPro is developed based on an industrial-grade web framework and a computation-oriented MS data format to improve analysis efficiency. Algorithms from mainstream metabolomics software are integrated and optimized for more accurate quantification results. A semi-targeted analysis workflow is designed based on the concept of combining artificial judgment and algorithm inference.

Results
MetaPro supports semi-targeted analysis workflow and functions for fast QC inspection and self-made spectral library curation with easy-to-use interfaces. With curated authentic or high-quality spectra, it can improve identification accuracy using different peak identification strategies. It demonstrates practical value in analyzing large amounts of metabolomics samples.

Conclusion
We offer MetaPro as a web-based application characterized by fast batch QC inspection and credible spectral curation towards high-throughput metabolomics data. It aims to resolve the analysis difficulty in semi-targeted metabolomics.