bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychrometry in the thermal comfort diagnosis of production animals: A combination of the systematic review and methodological proposal
Authors: Junior Sergio Luis de Castro , Silveira Robson Mateus Freitas , Silva Iran José Oliveira da 
Published: April 2023

Abstract

Animal welfare and zootechnical performance are compromised when animals are housed in environments which place them outside their thermal comfort zone. However, the identification of thermal stress, when based on air properties, suggests the use of outdated and generic indices. The objective of this work was to develop and validate a methodology for classifying and diagnosing heat stress in production animals based on psychrometric air relations. The model was created for broilers, pigs, dairy cattle, and laying birds, categorized into a total of 21 breeding phases. For each phase, a bibliographic search was carried out for the psychrometric parameters of the air - dry bulb temperature (AT) and relative humidity (RH) - that satisfied the animals' critical and ideal thermoneutral zones. Adding the local atmospheric pressure (AP), the parameters were used to calculate the enthalpy (h), resulting in five comfort ranges. Based on this, a decision tree was elaborated, consisting of three attributes (AT, RH, and h) and seven diagnostic classes, based on the psychrometric principles of air. The proposed methodology was used in a case study, with a database extracted from an individual shelter for calves. For the evaluation of the decision tree, two induction algorithms, ID3, and c4.5, were compared, both of which presented high accuracy and proposed simpler tree models than the one theoretically developed for the methodology. In conclusion, the methodology represents a great potential to characterize the thermal comfort of the animals, diagnose the causes of stress and recommend possible corrective actions. The study revealed that decision trees can be adapted and simplified for each creation phase.
Efficacy of Olanzapine, Netupitant, and Palonosetron in Controlling Nausea and Vomiting Associated with Highly Emetogenic Chemotherapy in Patients with Breast Cancer (OLNEPA)
Authors: de Rebouças Camilla Vieira , Alves Rafaela de Brito , Yamada Alayne Magalhães Trindade Domingues , Giglio Auro Del , Cruz Felipe José Silva Melo 
Published: April 2023

Abstract
Purpose: Chemotherapy-induced nausea and vomiting is a highly prevalent adverse event that could lead to worse treatment adherence and decreased quality of life1,2. To our knowledge, total dexamethasone omission from any regimen to prevent nausea and vomiting has not been evaluated2-4. This study aimed to address the efficacy of a three-drug protocol in preventing nausea and vomiting, with no corticosteroids included. Methods: This was a prospective single-arm phase II study designed to evaluate the efficacy of olanzapine, netupitant, and palonosetron in controlling nausea and vomiting induced by highly emetogenic chemotherapy. Patients were assigned to take olanzapine on Days 1–5 and netupitant and palonosetron on Day 1. No corticosteroid use was allowed. The primary endpoint was complete control of nausea in the first 5 days after chemotherapy administration. Secondary endpoints were complete emesis control (no emesis and no use of rescue medication) and complete control (no emesis, no rescue, and no nausea). Results: For the primary endpoint, the complete nausea control rate was 46% (CI 32–59%), with p < 0.0001. The emesis control rate was 68% (IC 55–80%), and the overall control rate was 46% (IC 32–59%). Conclusion: Omitting dexamethasone for highly emetogenic chemotherapy is feasible and showed a nausea and vomiting control rate that was similar to that of the standard four-drug protocol.
Trial registered by the number NCT04669132, on December 16, 2020, on clinicaltrials.gov platform.
Model-based hepatic percutaneous microwaveablation planning. First validation on a clinical dataset
Authors: Frackowiak Bruno , Bosch Vincent Van den , Tokoutsi Zoi , Baragona Marco , de Greef Martijn , Elevelt Aaldert , Isfort Peter 
Published: April 2023

Abstract
A model-based planning tool, integrated in an imaging system, is envisioned for CT-guided percutaneous microwave ablation. This study aims to evaluate the biophysical model performance, by comparing its prediction retrospectively with the actualablation ground truth from a clinical data set in liver. The biophysical model uses a simplified formulation of heat depositionon the applicator and a heat sink related to vasculature to solve the bioheat equation. A performance metric is defined toassess how the planned ablation overlaps the actual ground truth. Results demonstrate superiority of this model predictioncompared to manufacturer tabulated data and a significant influence of the vasculature cooling effect. Nevertheless, vasculatureshortage due to branches occlusion and applicator misalignment due to registration error between scans affects the thermalprediction. With a more accurate vasculature segmentation, occlusion risk can be estimated, whereas branches can be usedas liver landmarks to improve the registration accuracy. Overall, this study emphasizes the benefit of a model-based thermalablation solution in better planning the ablation procedures. Contrast and registration protocols must be adapted to facilitate itsintegration into the clinical workflow.
Elaborate Design and Mechanism Insight of Monodispersed AuCuPt Alloy Nanozyme with Promoted Antitumor Activity
Authors: Lin Jun , Liu Jing , Dong Shuming , Gai Shili , Dong Yushan , Liu Bin , Zhao Zhiyu , Yu Chenghao , Xie Ying , Yang Piaoping 
Published: April 2023

Abstract
The abrogation of the self-adaptive redox evolution of tumors is promising for improving therapeutic outcomes. In this study, we designed a novel trimetallic alloy nanozyme AuCuPt-PpIX (ACPP), which mimics up to five naturally occurring enzymes—glucose oxidase (GOD), superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), and glutathione peroxidase (GPx). Facilitated by these enzyme-mimicking traits, the constructed ACPP nanozymes can not only disrupt the established redox homeostasis in tumors through a series of enzymatic cascade reactions but also achieve cyclic regeneration of the relevant enzyme substrates. Density functional theory (DFT) calculations have theoretically explained the synergistic effect of multi-metallic doping and the possible mechanism of enzymatic catalysis. The doped Cu and Pt sites are conducive to the adsorption, activation, and dissociation of reactant molecules, whereas the Au sites are conducive to desorption, which significantly improves catalytic efficiency via a synergistic effect. Additionally, ACPP nanozymes can improve the effect of protoporphyrin (PpIX)-enabled sonodynamic therapy (SDT) by alleviating hypoxia and initiating ferroptosis by inducing lipid peroxidation (LPO) and inhibiting GPX4 activity, thus achieving multi-modal synergistic therapy. This study presents a typical paradigm to enable the use of multi-metallic alloy nanozymes for the treatment of tumor cells with self-adaptive properties.
thyroidectomy complications after ligasure small jaw use, case control, prospective study
Authors: alharbi mohammad 
Published: April 2023

Abstract
Introduction: The ligasure small jaw (LISJ) has many advantages for thyroid surgery hemostasis. Other complications, however, remain at the same level or are even greater than with conventional treatment.
Material and methodology: Between March and December of 2022, I analyzed complications following total thyroidectomy (TTH). Patients were evaluated prospectively for case control study. including hypocalcemia (HC) and recurrent laryngeal nerve (RLND) palsy.
Results: all patients suffered from postoperative (HC) with Ca supplement with Vid D.one patient suffered with stridor after extubation.
Conclusion: To reduce the complication rate during thyroid surgery with a small jaw, more surgical expertise is required. In terms of (RLND) palsy and (HC), the current literature does not demonstrate a safety advantage of (LISJ) over conventional thyroid surgery that would justify a price increase.
Fe-Pd nanoflakes decorated on leached graphite disks for both methanol and formic acid electrooxidation with excellent electrocatalytic performance
Authors: Mojarrad Amir , Sabzi Reza , Faraji Masoud 
Published: April 2023

Abstract
This paper introduces a unique and simple method for making inexpensive electrocatalysts for use in direct methanol fuel cells. The leached Fe1-Pd1 NFs/graphite (leached Fe1-Pd1/G) disk electrode was successfully obtained via uniform dispersion of Zn powder into the matrix of commercial graphite powder (98%), pressing under optimized pressure followed by the treatment in H2SO4 solution containing Fe+2 and Pd+2 cations, leading to partial leaching out of Zn from graphite matrix as well as partial electroless substitution of Fe-Pd nanoflakes with Zn metal. According to morphology investigations, binary Fe-Pd nanoflakes with a large surface area developed evenly on the leached graphite disk. The leached Fe-Pd/G disk demonstrated exceptional electrocatalytic activity toward methanol and formic acid oxidation without electrocatalyst poisoning being observed, in contrast to the leached Pd /graphite and leached Fe /graphite disks. This is due to the high surface area and synergistic effect of Pd and Fe. The findings of this work may be used to the mass manufacture of graphite-based disks for commercial fuel cell applications using available graphite powders.
The translation process of the Culturally Sensitive Active Aging Scale for Community-Dwelling Older Adults in Pakistan
Authors: Bibi Rashida , Khan Roheeda Amanullah , Zeb Akhter , Yan Zhang , Anwar Nasir , Mian Nasar 
Published: April 2023

Abstract
Background: Active aging is define as older adults remaining active, connected, and contributing to society. To assess active aging in Pakistani elders, there is a scarcity of research tools to assess Active Aging levels in community-based older adults in Pakistan. Therefore, the aim of this study was to translate and validate the original English version of the Active Aging Scale into an Urdu version to measure active aging in community-based older adults in Pakistan.
Methods: We followed the guidelines of the International Society of Pharmacy Economic and Outcome Research (ISPOR) to translate the scale. The first phase consists of translation processes; the second phase is all about the validity and reliability of the scale. Construct validity, concurrent validity, and reliability were established for a 160-person sample of community-based older adults. The finding of test-retest reliability was performed after a two-week interval on the remaining 30% of the sample. For concurrent validity, the Successful Aging Scale (SAS) Urdu version was used as the gold standard and applied at the same time on the same sample. Data were analyzed in SPPSS version 23, and AMOS version 23.
Results: Our study pooled 29 items on the Active Aging Scale out of a possible 36. Two items were removed in the first process as not relevant to the context and two items that were not maintained inter-item covariance that is less than the value of 0.30 were removed. In the confirmatory factor analysis, three items with values below 0.40 in Varimax with Kaiser Normalization Rotation. Item loads ranged from 46 to 0.90, and were found to explain 65.42% of the total variance. Confirmatory factor analysis of the AAS shows Chi-squared (X2/df = 2.24) as the degree of freedom is acceptable when <3.00 in model fit indices. The root mean square error of approximation (RMSEA) is 0.042, the goodness of fit index (GFI) is 0.92, the adjusted goodness of fit index (AGFI) is 0.94, and the comparative fit index (CFI) values are 0.92 and 0.96, respectively, showing the good fit indices of the model. The test and retest reliability of the scale was significant (p=<0.05), and the Cronbach alpha of the scale is 0.92, which is reliable.
Changes in precipitation over Northwest China from 1973 to 2019: Variation characteristics and relationships with climatic factors
Authors: Wang Yongliang , Zhang Weijiang , Zhang Pengcheng , Tang Lian , Huang Yan , Feng Na 
Published: April 2023

Abstract
The Shaanxi-Gansu-Ningxia (SGN) region in Northwest China has been challenged by drought and water shortage for decades. The present study systematically assessed the spatio-temporal variation of precipitation and relationship with climatic factors in SGN region, and clarified the differences between the climate transition zone and other regions. Analyzed the precipitation and different climate factors at 30 weather stations from 1973 to 2019, and developed an analysis framework of precipitation recirculation. The results showed that precipitation at annual scale had decreased significantly (P < 0.01) at the rate of 1.46 mm/10a during 1973–2019, and precipitation had a pattern of northwest-southeast spaced distribution in spatial distribution. In terms of seasonal precipitation, the summer precipitation variability was more concentrated and contributes the most to annual precipitation variation, while winter had a limited effect on annual precipitation variability due to less precipitation. The correlation analysis showed that annual precipitation had significant associations with RH (R = 0.623, P < 0.01) and Tmax (R =-0.294, P < 0.05) from 1973 to 2019. We therefore suggest that decreased air humidity and elevated extreme temperature are probably important factors for the significant decreasing trend of precipitation in SGN region over the past 50 years.
Knee osteoarthritis with a high grade of Kellgren-Lawrence score is associated with a worse frailty status: Korean National Health and Nutrition Examination Survey (KNHANES)
Authors: Joo Sang Hyun , Song Jin Woo , Shin Kichul , Kim Min Jung , Lee Joongyub , Song Yeong Wook 
Published: April 2023

Abstract
Objective
Frailty as a syndrome of physical decline in late life is associated with adverse health outcomes. Knee osteoarthritis (KOA) could contribute to frailty conditions. The objective of this study was to evaluate the impact of KOA on frailty risk in a Korean National Health and Nutrition Examination Survey (KNHANES) cohort.
Methods
In this study, KOA patients were defined as those with knee joint pain and grade 2 Kellgren-Lawrence (K-L) or more on plain radiographic images who were 40 years old or older in Korean population data of KNHANES. The frailty index was calculated using 46 items related to co-morbidities and laboratory parameters. The impact of KOA on frailty risk was evaluated with logistic regression analyses.
Results
The prevalence of KOA patients was 35.6% [95% CI: 34.7-36.46]. In polytomous logistic regression, the relative risk ratio (RRR) of KOA was significantly increased in the pre-frail group (2.76, 95% CI: 2.30-3.31) and the frail group (7.28, 95% CI: 5.90-8.98). RRR of frailty was significantly increased in patients with K-L grade 3 (1.36, 95% CI: 1.13-1.63) and K-L grade 4 (2.19, 95% CI: 1.72-2.79). Older age, higher BMI, higher WBC count, higher platelet count, and higher serum creatinine level were significantly associated with increased frailty risk. Lower hemoglobin and lower estimated GFR were associated with increased frailty risk in KOA patients.
Conclusion
In this large observation survey cohort, KOA is associated with an increased risk of frailty syndrome.
Robust real-time imaging through flexible multimode fibers
Authors: Abdulaziz Abdullah , Mekhail Simon Peter , Altmann Yoann , Padgett Miles J. , McLaughlin Stephen 
Published: April 2023

Abstract
Conventional endoscopes comprise a bundle of optical fibers, associating one fiber for each pixel in the image. In principle, this can be reduced to a single multimode optical fiber (MMF), the width of a human hair, with one fiber spatial-mode per image pixel. However, images transmitted through a MMF emerge as unrecognisable speckle patterns due to dispersion and coupling between the spatial modes of the fiber. Furthermore, speckle patterns change as the fiber undergoes bending, making the use of MMFs in flexible imaging applications even more complicated. In this paper, we propose a real-time imaging system using flexible MMFs, but which is robust to bending. Our approach does not require access or feedback signal from the distal end of the fiber during imaging. We leverage a variational autoencoder (VAE) to reconstruct and classify images from the speckles and show that these images can still be recovered when the bend configuration of the fiber is changed to one that was not part of the training set. We utilize a MMF 300 mm long with a 50 um core for imaging 10x10 cm objects placed approximately at 20 cm from the fiber and the system can deal with a change in fiber bend of 50 degrees and range of movement of 8 cm.
Study protocol: Assessment of the usefulness and practicability of a psychoeducational intervention to prevent the negative psychological impact of the COVID-19 pandemic on primary care health workers
Authors: Aragonès Enric , Rodoreda Sara , Guitart Meritxell , Garcia Eva , Berenguera Anna , Martín Francisco , Rambla Concepció , Aaragonès Guillem , Calvo Antoni , Mas Ariadna , Basora Josep 
Published: April 2023

Abstract
Background
The COVID-19 pandemic has constituted an extraordinarily stressful situation for healthcare professionals and has led to psychological distress and an increase in various mental disorders. In the post-pandemic context, it is necessary to provide professionals with strategies and skills to manage this stressful situation and prevent or minimize its negative impact.
Methods
Aims: To assess the feasibility and clinical effects of a group psychoeducational program focused on preventing the adverse psychological and emotional effects of the pandemic on primary care workers, and to explore the experience and perceptions of participants with regard to the program from a qualitative perspective.
Design: A single-arm, before-and-after study conducted in primary care.
Setting: The 332 primary care centers of the Catalan Institute of Health (Catalonia)
Participants: The target population of the intervention is primary care workers of all professional profiles. The implementation strategy will also involve community psychologists, who will lead the psychoeducational groups, and the health organization promoting the implementation.
Intervention: A group psychoeducational program targeting primary care workers to promote emotional well-being and the ability to cope with stressful situations. Community psychologists will deliver it in the primary care centers they are linked to.
Measures: Mixed-methods evaluation, analyzing quantitative and qualitative data. A prospective assessment of the main outcomes (professional quality of life, psychological state, and resilience) will be performed using online questionnaires before and immediately after the intervention, and at 3 and 6 months. A qualitative study will be conducted, comprising focus groups and individual in-depth interviews with the participants in the intervention and the psychologists who provide it.
Ethics: The Research Ethics Committee of the Jordi Gol Primary Care Research Institute (IDIAP) has approved the protocol (22/086-PCV).
Discussion
This project proposes an intervention to promote mental health and psychological well-being in primary care workers by learning skills and integrating them into personal and professional life. The expected results will allow us to determine the usefulness and effectiveness of this psychoeducational intervention under the conditions of real clinical practice, provide data to model and perfect it, and promote its dissemination.
Trial registration
ClinicalTrials.gov Identifier: NCT05720429.
Lipid Mediators as an index of psoriatic severity
Authors: Al-Ashoor Zainab A. , Haddad Nazar S. , Al-Hamdi Khalil I. 
Published: April 2023

Abstract
Psoriasis is one of the most common chronic inflammatory skin diseases resulting from a complex genetic background with environmental triggers. The bioactive Lipid mediators (12-hydroxyeicosatetraenoic acid (12-HETE) and 13-hydroxy octadecadienoic acid (13-HODE)) that generated involved in a variety of physiological and pathological processes. The study aims to assess the levels of bioactive lipid mediators (12- HETE and 13-HODE) in the serum and skin of psoriatic patients compared with healthy individuals and to study the association between the levels of bioactive lipid mediators in psoriatic patients with psoriasis severity measured by PASI score. Thirty-one patients with psoriasis were enrolled in the study, with 20 age and sex-matched apparently healthy subjects. The type of psoriasis and PASI score were assessed for psoriatic patients. Serum levels of 12-HETE, 13-HODE and other investigations were determined in psoriatic and healthy control groups, and the skin levels of 12-HETE and 13-HODE were also determined in lesional and non-lesional skin biopsies of psoriatic patients. There were statistically significant differences in the mean serum levels of 12-HETE and 13-HODE among the three psoriasis severity groups with (P = 0.002, P = 0.04), respectively. The serum levels of 12-HETE and 13-HODE were positively correlated with increasing psoriasis severity measured by PASI score with (r = 0.86, p = 0.001), (r = 0.87, p = 0.001), respectively. In conclusion, The level of both lipid mediators (12-HETE and 13-HODE) had significantly increased in the serum of psoriatic patients with a significant positive correlation with the severity of psoriatic disease as assessed by the PASI scoring system.
Unexpected Quasi-Alternating Copolymerization of Oxiranes Driven by a Benign Acetate-based Catalyst
Authors: Coulembier Olivier , Fornaciari Charlotte , Lemaur Vincent , Pasini Dario 
Published: April 2023

Abstract
An in-depth investigation of the oxyanionic ring-opening copolymerization of propylene oxide (PO) and allyl glydicyl ether (AGE) from benzyl alcohol (BnOH) activated with potassium acetate (KOAc) complexed by 18-crown-6 ether (18C6) is described. We demonstrate that the KOAc/18C6 complex is an efficient and benign catalytic system to promote copolymerization of both oxirane monomers, leading well-defined polyethers with varied co-monomer content and low dispersity values (ƉM < 1.20). Kinetic analysis confirmed the controlled nature of the (co)polymerization process, and the determination of reactivity ratios by 1H NMR spectroscopy revealed a quasi-alternating copolymerization profile, according to the Fineman-Ross method. These results highlight the great potential of 18C6/KOAc-mediated copolymerization process for the design of highly sought quasi-alternating copolymer platforms, not accessible with the common polymerization systems.