bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive value of CXCL10 for the occurrence of immune‐related adverse events in patient with renal cell carcinoma
Authors: Miura Yuji , Motoshima Takanobu , Anami Toshiki , Yano Hiromu , Mito Remi , Pan Cheng , Urakami Shinji , Kinowaki Keiichi , Tsukamoto Hirotake , Kurahashi Ryoma , Murakami Yoji , Yatsuda Junji , Fujiwara Yukio , Kamba Tomomi , Komohara Yoshihiro 
Published: March 2023

AbstractImmune checkpoint inhibitors (ICIs) have recently improved the prognosis of various cancers. By contrast, some immune‐related adverse events (irAEs) caused by ICIs are fatal and have become problematic. The pathogenesis of irAEs remains unknown and must be elucidated to establish biomarkers. This study investigated plasma cytokine, chemokine, and anti‐CD74 autoantibody levels in patients with renal cell carcinoma (RCC) and analyzed their association with irAEs. In a discovery cohort of 13 patients, plasma levels of chemokine (C–X–C motif) ligand (CXCL) 1, IL‐17A, IL‐1β, IL‐6, IL‐8, CXCL10, MCP‐1, and TNFα were measured at baseline and post–dose 1. Only CXCL10, at post–dose 1 but not at baseline, was significantly associated with grade 2 or higher irAEs (P = 0.0413). Plasma CXCL10 levels were then measured at baseline and post–dose 1 in an extended cohort of 43 patients with RCC who received ICI‐based treatment. Higher plasma CXCL10 levels both at baseline and post–dose1 were significantly associated with the occurrence of grade 2 or higher irAEs (P = 0.0246 and 0.0137, respectively). Plasma CXCL13 levels, which we measured in a previous study, were significantly higher in patients with grade 2 or higher irAEs at baseline but not at post–dose 1 (P = 0.0037 and 0.052, respectively). No significant association between plasma anti‐CD74 autoantibody level and both irAE pneumonitis and any grade 2 or higher irAE was observed. In conclusion, plasma CXCL10 is significantly associated with the occurrence of irAEs in patients with RCC treated with ICIs. CXCL10 is a potential predictive and on‐treatment biomarker for irAEs.
The effectiveness of weather index insurance in managing mariculture production risk
Authors: Qiang Mengmeng , Shen Manhong , Xia Guanjun 
Published: March 2023

AbstractMariculture is a high‐risk industry that is susceptible to weather disasters. However, due to moral hazard, adverse selection and high transaction costs, traditional indemnity insurance policies are not available. An emerging alternative is the development of weather index mariculture insurance. This research assesses the effectiveness of weather index mariculture insurance by using the swimming crab precipitation index insurance as an example. The theoretical and empirical results suggest that weather index mariculture insurance is not always effective. It cannot be guaranteed to promote the welfare of mariculturists and reduce the tail risk of income, especially in the case of gross rates. However, in the case of low basis risk, it could be a viable option for the government because of the low subsidy cost required.
ON URBAN RE‐ARRANGEMENTS: A Suite in Five Movements
Authors:   The Re‐Arrangements Collective, Cante Fabien , Hussain Ajmal , Makori Timo , Mohamed Surer Qassim , Osbourne Alana , Pilo’ Francesca , Ramakrishnan Kavita , Simone AbdouMaliq , Sitas Rike , Suhail Adeem 
Published: March 2023

AbstractThis movement introduces the ethos of the collective project: its conceptual and practical preoccupations. It focuses on our concern with urban processes on the cusp of change, in the midst of being re‐arranged, and thus homes in on the various polyrhythms of intersections, how things come together and diverge, how possibilities open and close in urban contexts of continuously shifting horizons.
A combination of acidic electrolyzed water with modified atmosphere packaging improves quality of jujube during cold storage by enhancing antioxidant activity
Authors: Li Yan , Jia Lili , Liu Guishan , He Jianguo , Li Yue , Zhang Yuanlv , Ma Haiyang 
Published: March 2023

AbstractThis study aimed to investigate the effects of a combination of acidic electrolyzed water (AEW) and modified atmosphere packaging (MAP) on the quality of jujube stored at 1 ± 0.5°C for 40 days. Jujube was treated with AEW + MAP, AEW, and MAP, respectively, to identify an appropriate preservation method based on the changes of quality indicators, activities of antioxidant enzymes and nonenzymatic antioxidant systems, malondialdehyde (MDA) content, and cell membrane permeability. Results showed that the combined treatment maintained higher storage quality of jujube than the other three treatments. The combined treatment significantly suppressed softening, weight, and color loss and maintained total soluble solid and titratable acidity. Moreover, the combined treatment improved antioxidant capacity showing high levels of nonenzymatic antioxidant systems (ascorbic acid and 1,1‐diphenyl‐2‐picrylhydrazyl radical scavenging capacity), and the activities of antioxidant enzymes (ascorbate peroxidase, superoxide dismutase, and catalase). These effects remarkably suppressed the increase of MDA level and cell membrane permeability, thereby inhibiting oxidative damage and alleviating quality deterioration. Furthermore, kinetic model indicated that AEW + MAP decreased rate constant of quality deterioration. Principal component analysis also showed that AEW + MAP treatment alleviated quality deterioration, with higher comprehensive score than other treatments. In summary, AEW + MAP was an effective preservation method to maintain storage quality and delay postharvest senescence of jujube.Practical ApplicationIn this study, a combination of acidic electrolyzed water (AEW) with modified atmosphere packaging (MAP) has been found to have effective preservation effects on jujube. AEW + MAP treatment improved quality of jujube during cold storage mainly by enhancing antioxidant capacity. The combined treatment may provide a new preservation technology for jujube.
MPO‐ANCA‐positive granulomatosis with polyangiitis and concurrent IgG4‐related disease with periaortitis and tubulointerstitial nephritis: A case report of a new overlap syndrome?
Authors: Kuske Luise , Khalifa Abedalrazag , Wibisono Alexander , Bräsen Jan Hinrich , Witte Torsten 
Published: March 2023

AbstractImmunoglobulin G4‐related disease (IgG4‐RD) is a fibroinflammatory condition that was first recognized as a unique disease entity in the early 2000s. Its diagnosis is based on specific pathologic, serologic, and clinical features, and the exclusion of several differential diagnoses, such antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV). However, emerging evidence suggests that these 2 conditions may overlap in some cases. Here, we report a new case of overlapping IgG4‐RD and AAV. The patient was diagnosed with IgG4‐RD owing to the presence of periaortitis and IgG4 positive tubulointerstitial nephritis. Myeloperoxidase (MPO)‐ANCA positivity, chronic paranasal sinusitis, and glomerulonephritis with granuloma led to a concurrent diagnosis of MPO‐ANCA‐positive granulomatosis with polyangiitis. Our case supports the hypothesis that diagnoses of IgG4‐RD and AAV are not mutually exclusive but can overlap. It can be assumed that an overlap with IgG4‐RD typically affects the granulomatous form of AAV, suggesting a common pathophysiological pathway for these 2 conditions.
The assessment of rheumatoid factor levels and hemogram parameters as predictors for rheumatologic disease
Authors: Limon Muhammet 
Published: March 2023

AbstractAimMany markers are used for clinical diagnosis in rheumatic diseases; rheumatoid factor (RF) is the most frequently used marker. However, RF is not specific to rheumatoid arthritis (RA). RF positivity is widely observed in patients with advanced age, infectious, autoimmune, and lymphoproliferative diseases. In this context, the objective of this study is to investigate the demographic characteristics, frequency of antinuclear antibody (ANA) and anti‐cyclic citrullinated peptide (anti‐CCP) positivity, hemogram parameters and distribution of the diagnoses in RF‐positive patients followed at the rheumatology clinic.MethodsThe population of this retrospective study consisted of patients above 18 years of age who were referred to have RF positivity by nephelometric method at Kahramanmaraş Necip Fazıl City Hospital Rheumatology Clinic between January 2020 and June 2022.ResultsThe mean age of the 230 patients with a positive RF test result, 155 (76%) male and 55 (24%) female, was 52.7 ± 15.5 years. There were 81 (35.2%), 54 (23.5%), 73 (31.7%) and 22 (9.6%) patients with RF levels between 20 and 50 IU/mL, 50 and 100 IU/mL, 100 and 500 IU/mL, and above 500 IU/mL, respectively. There was no significant difference detected between the groups that were created based on the RF titers regarding demographic characteristics (P > 0.05). The rate of being diagnosed with any rheumatic disease was significantly lower in the group with RF levels between 20 and 50 IU/mL compared to other groups (P = 0.001). The distribution of rheumatic and non‐rheumatic disease diagnoses according to RF levels did not reveal any significant difference between the groups (P = 0.369 and P = 0.147, respectively). RA was the most common (62.2%) rheumatic disease diagnosis among the patients included in the study. The leukocyte count was significantly higher in the group with RF levels above 500 IU/mL compared to the group with RF levels between 20 and 50 IU/mL (P = 0.024). There was no significant difference between the groups in other laboratory results, that is, hemogram, sedimentation, C‐reactive protein, platelet, and lymphocyte/monocyte ratio (P > 0.05).ConclusionThe study findings indicate that RF positivity can be seen in the context of different rheumatological diseases; hence RF levels alone may not predict rheumatological disease. There was also no significant relationship between RF levels and ANA and anti‐CCP positivity. The most common diagnosis in patients presenting with elevated RF levels was RA. Nevertheless, it should be noted that RF can be found asymptomatically in the general population.
Comparing estimates of census and effective population size in an endangered amphibian
Authors: Brooks G. C. , Wendt A. , Haas C. A. , Roberts J. H. 
Published: March 2023

AbstractThe field of conservation has seen a shift in focus from monitoring trends in census population size to trends in ‘effective’ population size. Numerous genetic methods exist for estimating effective population size, resulting in uncertainty among conservation practitioners as to which methods are most appropriate when conducting population assessments or evaluating recovery efforts. Demographic approaches offer a promising avenue to provide a link between census and effective population size using life‐history information, but rarely do studies have all three sources of data (genetic, demographic, life history) necessary to perform an explicit evaluation of their performance. Using data from a long‐term study of reticulated flatwoods salamanders (Ambystoma bishopi) in western Florida, USA, we assessed the magnitude of temporal variation in census population sizes and the effective number of breeders of two breeding populations to (1) document changes in the number of breeding adults over the 9‐year study duration, (2) determine whether and provide similar information about population size and trends and (3) compare alternative demographic and genetic approaches for estimating . We found that genetic estimates of , particularly if averaged across multiple estimation methods, closely tracked spatiotemporal variation in . Demographic estimates of also closely tracked but were sensitive to the assumed variance in reproductive success. In the absence of genetic information, detailed knowledge of mating systems and the environmental factors that skew reproductive contributions appear necessary for demographic to reliably inform management decisions. In these populations, appears too small (<40 individuals) to confer long‐term genetic resilience, highlighting the importance of restoring landscape connectivity and indicating that caution must be taken when sourcing animals for reintroduction efforts. More generally, our study reveals insights into the utility of alternative estimation methods in guiding recovery efforts of threatened and endangered species.
Effects of water stress on plant volatile emission and insect oviposition preference in an agroecosystem
Authors: Sun Yan , Zhu Xuewei , Sui Li , Zhu Ziqiu , Ren Bingzhong , Pan Duofeng , Wan Ho Yi , Zhu Hui 
Published: March 2023

Abstract
Drought has become more common and severe in many parts of the world due to climate change. The effect of water stress on insect oviposition preference that is key determinant for their fitness has received less attention.
Here, we examined how water stress may affect oviposition selection of Ostrinia furnacalis for maize plants in the greenhouse, and tested difference in volatile compounds emitted from treated maize, and electronantennogram and bioassay responses of O. furnacalis to the volatile profiles in maize plants.
Ostrinia furnacalis were more prone to lay eggs on the well‐watered maize. Most plant volatile compounds differed significantly among the three water treatments, including increased emissions of β‐caryophyllene, (E)‐2‐hexenal, and linalool, and decreased emission of (Z)‐3‐hexen‐1‐ol when subjected to increasing intensity of drought.
Varied volatile profiles of maize may drive oviposition decision of O. furnacalis, because O. furnacalis showed a clear oviposition preference for (Z)‐3‐hexen‐1‐ol, while not for β‐caryophyllene, (E)‐2‐hexenal, and linalool, at the concentration of 1000 ppm.
This study advances understanding of drought effects on plant–insect interactions through volatile profiles. Our finding calls for attention to oviposition selection for insect pest management in agricultural settings, especially in regions under changing precipitation patterns.
Digital screening and brief intervention for alcohol misuse in college students: A pilot, mixed‐methods, cluster randomized controlled trial from a low‐resourced setting
Authors: Ghosh Abhishek , Krishnan Narayanan C. , Kathirvel Soundappan , Pillai Renjith R. , Basu Debasish , George Blessy B. , P. V. Aswathy , Sharma Kshitiz , Kumar Anil 
Published: March 2023

AbstractIntroductionWe examined the feasibility and acceptability of digital screening and brief intervention (d‐SBI) for alcohol misuse in college students; the effectiveness of d‐SBI was our secondary outcome. We also explored the barriers and facilitators of d‐SBI.MethodsThe study design is a mixed‐methods, pilot, and cluster randomized trial. Five colleges from a northern city in India were randomly allocated to d‐SBI and control groups. One hundred and ninety‐one students were screened, and 25 (male = 23 and female = 2) participants (age 19.62 ± 2.58 years) fulfilled eligibility. All participants completed follow‐up assessments at 3 months. In‐depth interviews were done with 11 participants. Alcohol Use Disorder Identification Test (AUDIT) based screening brief intervention was provided on a web portal‐ or mobile application in the d‐SBI group. The control group received digital screening and brief education. Direct questions and usage statistics assessed the measurement acceptability of the intervention. We compared the change in AUDIT scores in the intervention groups over 3 months post‐intervention. Thematic analyses of transcripts of interviews were done by inductive coding.ResultsMost participants reported that d‐SBI was user‐friendly (80%), advice was appropriate (80%), and perceived it to be useful (72%). Ninety‐six percent of users, who logged in, completed screening. There was a significant decrease in AUDIT scores both in d‐SBI (p < .001) and control groups (p < .001). Time and group significantly affected the mean AUDIT score, but time × group interaction was non‐significant. Thematic analysis revealed six overarching themes.ConclusionsDigital SBI for alcohol misuse is acceptable, feasible, and possibly effective among college students from low‐resource settings.
Clinical significance and impact of gastric non‐Helicobacter pylori Helicobacter species in gastric disease
Authors: Taillieu Emily , De Witte Chloë , De Schepper Heiko , Van Moerkercke Wouter , Rutten Sophie , Michiels Stijn , Arnst Yuna , De Bruyckere Sofie , Francque Sven , van Aert Frauke , George Christophe , Callewaert Emma , Callewaert Tiene , Vanneste Glenn , Vanderstraeten Erik , Van Heddegem Nina , Vansteelant Margaux , Chiers Koen , Haesebrouck Freddy , Van Steenkiste Christophe 
Published: March 2023

SummaryBackgroundGastric non‐Helicobacter pylori Helicobacter (NHPH) species naturally associated with animals have been linked with gastric disease in human patients.AimThe prevalence and clinical significance of zoonotic gastric NHPHs was determined in large and well‐defined, H. pylori‐negative, gastric patient populations.MethodsPatients were retrospectively (n = 464) and prospectively (n = 65) included for gastric biopsy collection: chronic gastritis (CG), peptic ulcer disease and gastric MALT lymphoma, without identified aetiology. PCR and sequencing was performed for the detection of gastric Helicobacter species. Retrospectively, asymptomatic gastric bypass patients (n = 38) were included as controls. Prospectively, additional saliva samples and symptom and risk factor questionnaires were collected. In this group, patients with gastric NHPH infection were administered standard H. pylori eradication therapy and underwent follow‐up gastroscopy post‐therapy.ResultsIn the retrospective samples, the prevalence of gastric NHPHs was 29.1%, while no gastric NHPHs were detected in control biopsies. In the prospective cohort, a similar proportion tested positive: 27.7% in gastric tissue and 20.6% in saliva. The sensitivity and accuracy for the detection of gastric NHPHs in saliva compared to gastric tissue was 27.8% and 69.8% respectively. Following eradication therapy, clinical remission was registered in 12 of 17 patients, histological remission in seven of nine and eradication in four of eight patients.ConclusionThese findings suggest a pathophysiological involvement of NHPHs in gastric disease. Patients presenting with gastric complaints may benefit from routine PCR testing for zoonotic gastric NHPHs.
Mic60 is essential to maintain mitochondrial integrity and to prevent encephalomyopathy
Authors: Dong Tingting , Zhang Zai‐Qiang , Sun Li‐Hong , Zhang Weilong , Zhu Zhaohui , Lin Lin , Yang Lin , Lv An , Liu Chunying , Li Qing , Yang Rui‐Feng , Zhang Xiuru , Niu Yamei , Chen Hou‐Zao , Liu De‐Pei , Tong Wei‐Min 
Published: March 2023

AbstractMitochondrial encephalomyopathies (ME) are frequently associated with mutations of mitochondrial DNA, but the pathogenesis of a subset of ME (sME) remains elusive. Here we report that haploinsufficiency of a mitochondrial inner membrane protein, Mic60, causes progressive neurological abnormalities with insulted mitochondrial structure and neuronal loss in mice. In addition, haploinsufficiency of Mic60 reduces mitochondrial membrane potential and cellular ATP production, increases reactive oxygen species, and alters mitochondrial oxidative phosphorylation complexes in neurons in an age‐dependent manner. Moreover, haploinsufficiency of Mic60 compromises brain glucose intake and oxygen consumption in mice, resembling human ME syndrome. We further discover that MIC60 protein expression declined significantly in human sME, implying that insufficient MIC60 may contribute for pathogenesis of human ME. Notably, systemic administration of antioxidant N‐acetylcysteine largely reverses mitochondrial dysfunctions and metabolic disorders in haplo‐insufficient Mic60 mice, also restores neurological abnormal symptom. These results reveal Mic60 is required in the maintenance of mitochondrial integrity and function, and likely a potential therapeutics target for mitochondrial encephalomyopathies.
Active sensitization to dimethylthiocarbamylbenzothiazol sulphide: An unexpectedly strong rubber contact allergen
Authors: Isaksson Marléne , Bergendorff Ola , Hamnerius Nils , Pontén Ann , Svedman Cecilia , Hauksson Inese , Bruze Magnus 
Published: March 2023

AbstractBackgroundThe two dialkylthiocarbamyl benzothiazole sulphides, dimethyl‐thiocarbamylbenzothiazole sulphide (DMTBS) and diethylthio‐carbamylbenzothiazole sulphide (DETBS) were shown to be good markers of both thiuram and mercaptobenzothiazole sensitivity.ObjectivesTo investigate if DMTBS and/or DETBS could be better markers of contact allergy to common rubber additives than the ones currently used.MethodsSixty‐eight dermatitis patients were patch tested with DMTBS and DETBS, both at 1% in petrolatum (pet). Because of late reactions in 10 patients, these were retested to DMTBS and DETBS in serial dilutions. Tetramethylthiuram monosulphide (TMTM) 1.0% pet was also tested.ResultsAt the initial reading Days 3 and 7, no reactions were noted to DMTBS or DETBS. At retesting, 10 of the 68 (15%) patients reacted positively to lower concentrations of DMTBS than the initial test concentration. Seven of 8 also reacted to TMTM. Three of them had positive reactions to DEBTS. All 10 patients had reactions to more diluted solutions to DMBTS than to DEBTS (p = 0.0077; Mc‐Nemar test, two‐sided).ConclusionsResults speak for patch test sensitization to DMTBS with cross‐reactivity to TMTM and also DEBTS. DMTBS and DEBTS could be new markers of rubber allergy but a safe test concentration must be found.
Bone marrow‐derived mesenchymal stem cells attenuate complete Freund's adjuvant‐induced inflammatory pain by inhibiting the expression of P2X3
Authors: Deng Yifan , Yuan Dongdong , Deng Zhizhao , Liang Jianfen , Zhang Zhenye , Hei Ziqing , Li Xiang 
Published: March 2023

AbstractBone marrow‐derived mesenchymal stem cells (BMSCs) show a good property for pain treatment by modulating inflammatory response. However, the underlying therapeutic effect and related mechanism of BMSCs on inflammatory pain remain unclear. Therefore, we explored the function and potential mechanism of BMSCs performing in a complete Freund's adjuvant (CFA)‐induced inflammatory pain model in this study. Here, BMSCs were injected into the CFA‐treated rats, and we used behavioural tests to evaluate the changes in hypersensitivity. High‐throughput sequencing was used to screen out the hub genes. Molecular biology experiments were performed to detect the level of P2X3 or inflammatory mediators in rats and observed the distribution of P2X3 in neural cells. Furthermore, the function of the P2X3 was explored via inhibitor and activator experiments. Finally, we found that BMSCs alleviated hyperalgesia and spinal levels of pro‐inflammatory factors in CFA‐treated rats. High‐throughput sequencing showed that P2X3 and P2X7 were identified as hub genes, and only the expression level of P2X3 was significantly down‐regulated after BMSCs treatment. Immunohistochemistry showed that P2X3 mainly colocalized with microglia and astrocytes. The levels of P2X3 and pro‐inflammatory factors were all significantly reduced after BMSC injection. Moreover, similar attenuation was found in the CFA‐treated rats after injecting the P2X3 inhibitor, and a P2X3 antagonist reversed the attenuation induced by the BMSCs. These findings suggest that BMSCs exerted a therapeutic effect on inflammatory pain by inhibiting the expression of P2X3 and the excessive production of inflammatory mediators was associated with an increased P2X3 level and BMSC therapy reverse these effects.