bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shared and Distinct Gut Microbiota in Spondyloarthritis, Acute Anterior Uveitis, and Crohn's Disease
Authors: Essex Morgan , Rios Rodriguez Valeria , Rademacher Judith , Proft Fabian , Löber Ulrike , Markó Lajos , Pleyer Uwe , Strowig Till , Marchand Jérémy , Kirwan Jennifer A. , Siegmund Britta , Forslund Sofia K. , Poddubnyy Denis 
Published: July 2023

ObjectiveSpondyloarthritis (SpA) is a group of immune‐mediated diseases highly concomitant with nonmusculoskeletal inflammatory disorders, such as acute anterior uveitis (AAU) and Crohn's disease (CD). The gut microbiome represents a promising avenue to elucidate shared and distinct underlying pathophysiology.MethodsWe performed 16S ribosomal RNA sequencing on stool samples of 277 patients (72 CD, 103 AAU, and 102 SpA) included in the German Spondyloarthritis Inception Cohort and 62 back pain controls without any inflammatory disorder. Discriminatory statistical methods were used to disentangle microbial disease signals from one another and a wide range of potential confounders. Patients were naive to or had not received treatment with biological disease‐modifying antirheumatic drugs (DMARDs) for >3 months before enrollment, providing a better approximation of a true baseline disease signal.ResultsWe identified a shared, immune‐mediated disease signal represented by low abundances of Lachnospiraceae taxa relative to controls, most notably Fusicatenibacter, which was most abundant in controls receiving nonsteroidal antiinflammatory drug monotherapy and implied to partially mediate higher serum C‐reactive protein. Patients with SpA showed an enrichment of Collinsella, whereas human leukocyte antigen (HLA)‐B27+ individuals displayed enriched Faecalibacterium. CD patients had higher abundances of a Ruminococcus taxon, and previous conventional/synthetic DMARD therapy was associated with increased Akkermansia.ConclusionOur work supports the existence of a common gut dysbiosis in SpA and related inflammatory pathologies. We reveal shared and disease‐specific microbial associations and suggest potential mediators of disease activity. Validation studies are needed to clarify the role of Fusicatenibacter in gut‐joint inflammation, and metagenomic resolution is needed to understand the relationship between Faecalibacterium commensals and HLA‐B27.image
Association between periodontitis and mortality of patients with cardiovascular diseases: A cohort study based on NHANES
Authors: Chen Fangman , Song Yansong , Li Weiqi , Xu Hao , Dan Hongxia , Chen Qianming 
Published: July 2023

AbstractBackgroundThe association between periodontitis and cardiovascular disease (CVD) has been widely explored, but little is known about the effect of periodontitis on the mortality of CVD patients. This study aims to clarify the effect of periodontitis on all‐cause and cause‐specific mortality of CVD patients.MethodsWe included 2,135 individuals with CVD from the National Health and Nutrition Examination Survey. Mortality data were ascertained by linkage to National Death Index records through 31 December 2019. We used Cox proportional hazards models for all‐cause mortality and competing risk models for CVD and cancer mortality to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Further covariate adjustments, stratification analyses, and a variety of sensitivity analyses were conducted to test the reliability and robustness of the results.ResultsThe all‐cause mortality in CVD patients with moderate/severe periodontitis was significantly higher than in those with no/mild periodontitis (HR: 1.25; 95% CI: 1.02–1.52; P = 0.03). The all‐cause mortality in participants with severe clinical attachment loss was significantly higher (HR: 1.07; 95% CI: 1.01–1.14; P = 0.01). However, no discrepancy in CVD or cancer mortality was observed between CVD patients with different periodontal status.ConclusionsOur findings from a longitudinal study with a large sample indicated significant but slightly higher all‐cause mortality in CVD patients with moderate/severe periodontitis than in those with no/mild periodontitis.
Applying sunflower oil to rapeseed plants reduces water loss
Authors: de Godoi Rudy Gomes Pereira , Kettlewell Peter Stephen 
Published: July 2023

AbstractBACKGROUNDHydrophobic polymers are used as antitranspirants to block stomata and reduce water loss from plants and thus drought stress, although the use of current commercial products is limited because they are expensive. Plant oils may be much cheaper hydrophobic polymers if they have similar efficacy to commercial antitranspirant products. Two experiments with pot‐grown rapeseed plants were conducted to compare sunflower oil with the commercially‐available antitranspirant di‐1‐p‐menthene (DPM) for efficacy in reducing water loss, and to test for a linear response to increasing oil concentration.RESULTSSunflower oil at the same concentration as DPM (0.5%) was similar in efficacy in reducing the rate of water loss, measured as both rate of weight loss of the plant and rate of stomatal conductance decline. There was a linear response to increasing concentrations of oil, as found in previous research with DPM on rapeseed, with a slower rate of water loss the greater the concentration.CONCLUSIONIf other plant oils are equally or more effective in reducing water loss as sunflower oil, there may be potential for plant oils to be used as low‐cost antitranspirants to reduce drought damage on large‐scale commodity crops, and also by smallholder farmers in low‐income countries using locally‐produced plant oils. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Abrechnung der chirurgischen Therapie des
Lipödems
Authors: Motamedi Melodi , Gensior Matthias H. L. , Ghods Mojtaba , Boos Anja M. , Kruppa Philipp , Allert Sixtus 
Published: July 2023

ZusammenfassungDie Abrechnung der Liposuktion des Lipödems gestaltet sich mittlerweile
mannigfaltig. Grundlage hierfür ist die Entscheidung des Gemeinsamen
Bundesausschusses (G-BA), das Lipödem Stadium III bis zum Abschluss der
Erprobungsstudie zu Lasten der Gesetzlichen Krankenversicherungen (GKV)
abrechenbar zu machen, sofern die Qualitätssicherungsrichtlinien
erfüllt sind. Demnach kann die operative Therapie bei Lipödem
Stadium III sowohl stationär, wie auch ambulant abgerechnet werden,
während die Übernahme der operativen Behandlung der anderen
beiden Stadien weiterhin einer Einzelfallentscheidung der GKV vorbehalten bleibt
und aktuell fast immer abgelehnt wird. Daher werden die Behandlungskosten von
den Betroffenen häufig privatärztlich oder als Selbstzahler
beglichen. Im Rahmen gerichtlicher Auseinandersetzungen stellt sich immer wieder
die Frage nach der korrekten Abrechnung des Lipödems, welche Gutachter
und Gerichte wiederholt vor eine schwierige Aufgabe stellt. Im folgenden Artikel
stellen wir als AG Lipödem der Deutschen Gesellschaft für
Plastische, Rekonstruktive und Ästhetische Chirurgie eine
Übersicht über die verschiedenen Abrechnungsmodalitäten
dar und stellen einen Vorschlag zur korrekten Abrechnung der Liposuktion des
Lipödems im Rahmen der GOÄ vor.
Acoustic Profiles
Authors: Jordan Randolph 
Published: July 2023

Abstract
This book proposes a sound ecology of the cinema, addressing film sound through the field of acoustic ecology. The book’s method is referred to as acoustic profiling, a theoretical tool for hearing how filmmakers articulate spatial dimensions in their works. This method is based on a double critical movement: application of acoustic ecology’s prescribed listening practices to film sound studies, and thinking about acoustic ecology as born of film studies, drawing on film studies’ long history of dealing with problems of fidelity and positionality through recording technologies to challenge some of the tenets of acoustic ecology. The core of the book is a set of close readings of specific films and media works across a range of international narrative fiction, documentary, and experimental forms to address ecological issues at play within the aesthetic and thematic content of these works while rethinking acoustic ecology as a set of media practices. To that end, the book demonstrates how the creative use of media technologies in different fields can be understood relationally through the ecological issues that connect them, revivifying acoustic ecology for media studies while broadening the latter’s ecological scope. The book provides a tool kit for readers to hear films with new ears, to think critically about this new listening practice, and to extend that engagement beyond the walls of the screening room by opening works of audiovisual media up to the consideration of soundscape research.
Engineering Analysis of Non-Braided Polycaprolactone Bioresorbable Flow Diverters for Aneurysms
Authors: Hossan Mohammad Robiul , Barot Vishal , Harriet Seth , Peters Lauren , Matsayko Alex Christopher , Bauer Andrew , Hossain Khalid 
Published: July 2023

Abstract
This paper reports a nonbraided, bioresorbable polycaprolactone (PCL) flow diverter (FD) for the endovascular treatment of aneurysms. Bioresorbable FDs can reduce the risk associated with the permanent metallic FDs as they are resorbed by the body after curing of aneurysms. PCL FDs were designed and fabricated using an in-house hybrid electromelt spinning-fused deposition fabrication unit. Flow diverter's properties, surface qualities, and mechanical characteristics of PCL FDs of 50%, 60%, and 70% porosities were studied using scanning electron microscope (SEM), atomic force microscopy (AFM), and high precision universal testing machine (UTM). The deployability through a clinically relevant catheter was demonstrated in a PDMS aneurysm model. The angiographic visibility of the developed PCL FDs was evaluated using BaSO4 and Bi2O3 coatings of various concentration. The average strut thicknesses were 74.12 ± 6.63 μm, 63.07 ± 1.26 μm, and 56.82 ± 2.09 μm for PCL FDs with 50%, 60%, and 70% porosities, respectively. They average pore areas for the 50%, 60% and 70% porosities FDs were 0.055 ± 0.0056 mm2, 0. 0605 ± 0.0065 mm2, and 0.0712 ± 0.012 mm2, respectively. The surface quality was great with an RMS roughness value of 14.45 nm. The tensile, radial strength, and flexibility were found to be satisfactory and comparable to the nonbraided coronary stents. The developed PCL FDs were highly flexible and demonstrated to be deployable through conventional delivery system as low as 4 Fr catheters in a PDMS aneurysm model. The visibility under X-ray increases with the increasing concentration of coating materials BaSO4 and Bi2O3. The visibility intensity was slightly higher with Bi2O3 coating of PCL FDs. The overall results of the engineering analysis of the developed nonbraided PCL FDs are promising.
Agent-Based Product-Social-Impact-Modeling: A Systematic Literature Review and Modeling Process
Authors: Mabey Christopher S. , Salmon John L. , Mattson Christopher A. 
Published: July 2023

Abstract
A key part of an engineer’s purpose is to create products and services that benefit society, or, in other words, to create products with a positive social impact. While engineers have many predictive models to aid in making design decisions about the functional performance or safety of a product, very few models exist for estimating or planning for the wide range of social impacts an engineered product can have. To model social impact, a model must contain representations of both the product and society. Agent-based modeling is a tool that can model society and incorporate social impact factors. In this paper, we investigate factors that have historically limited the usefulness of product adoption agent-based models and predictive social impact models through a systematic literature review. Common themes of limiting factors are identified, steps are presented to improve the usefulness of agent-based product adoption models and predictive social impact models, and a general process for the creation of agent-based social impact models is presented. Improving the usefulness of these predictive models can aid engineers in making better design decisions. Predictive social impact models can help identify areas in the design space to improve the social impact of products. When coupled with existing design methods, agent-based predictive social impact models can help increase the probability that a product achieves positive social impact.
Interprofessional education in a New Zealand Community Polytechnic: A mixed-method pilot study
Authors: Price Ashleigh Sara , Smith Lee , Gregan Marcella , Le Page Susie , Corlett Reuben , Westenra Belinda 
Published: July 2023

INTRODUCTION: Interprofessional collaboration leads to better patient care, enhanced teamwork skills, better communication, and enhanced understandings of each other’s professional roles.
METHODS: The objective of the study was to trial an interprofessional education (IPE) simulation activity with students (nine) from three health and social service disciplines in one community polytechnic. A pre-test/post-test design was used to gather data on the students’ perspectives of the IPE simulation and what the students learned from it. A simple Likert Scale questionnaire and two focus groups (with five and four participants, respectively) were conducted. A thematic analysis of the focus group data was undertaken while survey responses are presented in percentages for ease of readability.
FINDINGS: The participants enjoyed the simulation, had greater confidence with interprofessional communication post-participation and increased knowledge of each other’s scope of practice. The participants welcomed the opportunity to practise handover, which was an area of concern for all.
IMPLICATIONS: IPE is an invaluable tool for preparing students for their future careers as members of an interdisciplinary health team.
Looking Back: International Practice Patterns in Breast Radiation Oncology From a Case-Based Survey Across 54 Countries During the First Surge of the COVID-19 Pandemic
Authors: Oladeru Oluwadamilola T. , Dunn Samantha A. , Li Jian , Coles Charlotte E. , Yamauchi Chikako , Chang Jee Suk , Cheng Skye Hung-Chun , Kaidar-Person Orit , Meattini Icro , Ramiah Duvern , Kirby Anna , Hijal Tarek , Marta Gustavo Nader , Poortmans Philip , Isern-Verdum Josep , Zissiadis Yvonne , Offersen Birgitte Vrou , Refaat Tamer , Elsayad Khaled , Hijazi Hussam , Dengina Natalia , Belkacemi Yazid , Luo Feng Deng , Lu Shun , Griffin Colleen , Collins Maya , Ryan Phoebe , Larios Dalia , Warren Laura E. , Punglia Rinaa S. , Wong Julia S. , Spiegel Daphna Y. , Jagsi Reshma , Taghian Alphonse , Bellon Jennifer R. , Ho Alice Y. 
Published: July 2023

PURPOSE The COVID-19 pandemic has profoundly affected cancer care worldwide, including radiation therapy (RT) for breast cancer (BC), because of risk-based resource allocation. We report the evolution of international breast RT practices during the beginning of the pandemic, focusing on differences in treatment recommendations between countries. MATERIALS AND METHODS Between July and November 2020, a 58-question survey was distributed to radiation oncologists (ROs) through international professional societies. Changes in RT decision making during the first surge of the pandemic were evaluated across six hypothetical scenarios, including the management of ductal carcinoma in situ (DCIS), early-stage, locally advanced, and metastatic BC. The significance of changes in responses before and during the pandemic was examined using chi-square and McNemar-Bowker tests. RESULTS One thousand one hundred three ROs from 54 countries completed the survey. Incomplete responses (254) were excluded from the analysis. Most respondents were from the United States (285), Japan (117), Italy (63), Canada (58), and Brazil (56). Twenty-one percent (230) of respondents reported treating at least one patient with BC who was COVID-19–positive. Approximately 60% of respondents reported no change in treatment recommendation during the pandemic, except for patients with metastatic disease, for which 57.7% (636/1,103; P < .0005) changed their palliative practice. Among respondents who noted a change in their recommendation during the first surge of the pandemic, omitting, delaying, and adopting short-course RT were the most frequent changes, with most transitioning to moderate hypofractionation for DCIS and early-stage BC. CONCLUSION Early in the COVID-19 pandemic, significant changes in global RT practice patterns for BC were introduced. The impact of published results from the FAST FORWARD trial supporting ultrahypofractionation likely confounded the interpretation of the pandemic's independent influence on RT delivery.
Digital Platform Regulation: Global Perspectives on Internet Governance, Terry Flew and Fiona R. Martin (eds) (2022)
Authors: Hoskins Guy T. 
Published: July 2023

Review of: Digital Platform Regulation: Global Perspectives on Internet Governance, Terry Flew and Fiona R. Martin (eds) (2022)
Cham: Springer International Publishing, 319 pp.,
ISBN 978-3-03095-220-4, e-book, USD 49.99
Investigating the effect of hesperitine on estrogen receptor expression, phosphorylation and activity in MCF-7 cells
Authors: Vosooghi Ramin , Motavalizadehkakhky Alireza , mansouri atena , Mehrzad Jamshid , Homayouni Masood 
Published: July 2023

Abstract
Background
The most typical malignancy among women worldwide is breast cancer. Estrogen receptor play a vital role in this cancer. One of the most known mechanisms that affect the activity of this receptor is its phosphorylation by protein kinase pathways. Studies have shown that hesperetin has an effect on intracellular kinase pathways.
Purpose
The aim of this study was to investigate the effect of hesperetin on the level of expression, phosphorylation and activity of estrogen receptor .
Study design and methods:
MCF-7 cells were cultured in RPMI 1640 phenol red free medium containing charcoal stripped FBS and treated with hesperetin. MTT method was used to evaluate cell survival. The level of ERα protein and its phosphorylated form (Ser118) was determined by western blot technique. Luciferase reporter vector was used to evaluate ERE activity.
Results
The results of this study indicated that hesperetin reduced the survival of MCF-7 cells in a dose dependent manner. The level of expression and phosphorylation (Ser118) of estrogen receptor indicated a significant increase and decrease in the groups treated with hesperetin, respectively. Hesperetin increased the activity of the estrogen receptor in the nonexistence of E2, while in the existence of E2 it caused a significant decrease in receptor activity.
Conclusion
Based on the results of this study, it can be concluded that hesperetin has a significant effect on estrogen receptor expression, phosphorylation and activity probably through protein kinase pathways.
Development and optimization of active edible coatings to improve the shelf life of Indian soft cheese
Authors: Prajapati Priyanka , Garg Meenakshi , Akhtar Saamir , Ansari Tehrir H. , Chopra Rajni , Anand Purnima , Sadhu Susmita Dey 
Published: July 2023

Abstract
The use of active packaging systems that contain antimicrobial agents is considered to be a prudent method of ensuring the quality and safety of food. The purpose of the study was to design an edible coating system to protect Paneer (Indian cottage cheese) using Glycerin, Pectin, and Casein; the coating components were optimized by using the Central Composite Design (CCD) method of Response Surface Methodology (RSM). Different antimicrobial compounds, Copper Nanoparticles (CNP), Eugenol Essential oil (EO), were added to the optimized edible coating to investigate their efficacy by tracking the alteration in phsyico-chemical parameters of Paneer during storage of 14 days. The changes in Paneer were investigated through water distribution, acidity variation, rheological alterations and microbiological analysis during the storage period. Microbe proliferation was reduced by an average of 88.6% when copper nanoparticles were loaded into casein film on the fourteenth day after storage. As a result of the study, a casein-based film containing CNP was able to successfully retain moisture, maintain an optimal pH and ensure the safety and quality of Paneer. Additionally, further research is needed to assess the implication of CNP loaded edible coatings in food packaging as a means to minimize the associated risk associated with CNP consumption.
Non-coding RNAs and gastrointestinal cancers prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies
Authors: Zha Bowen , Luo Yuxi , Kamili Muladili , Zha Xiaqin 
Published: July 2023

AimProvide an overview and a systematic evaluation of the evidence quality on the association between non-coding RNAs (ncRNAs) and prognosis value for gastrointestinal cancers (GICs).MethodsWe searched the literature from three electronic databases: Pubmed, Embase, and Web of science, then carefully screened and extracted the primary information and results from the included articles. We use A measurable systematic review and meta-analysis evaluation tool (AMSTAR2) to evaluate the quality of methodology and then use the Grading of Recommendations Assessment 2, Development and Evaluation guideline (GRADE) make sure the reliability of the meta-analysis.ResultsOverall, 182 meta-analyses from 58 studies were included in this study. Most of these studies are of low or very low quality. Using the scoring tool, we found that only two meta-analyses were rated as high reliability, and 17 meta-analyses were rated as medium reliability.ConclusionsAlthough ncRNA has good prognostic value in some studies, only a tiny amount of evidence is highly credible at present. More research is needed in the future.PROSPERO registration numberCRD42022382296.
Measuring the willingness to share personal health information: a systematic review
Authors: Benevento Marcello , Mandarelli Gabriele , Carravetta Francesco , Ferorelli Davide , Caterino Cristina , Nicolì Simona , Massari Antonella , Solarino Biagio 
Published: July 2023

BackgroundIn the age of digitalization and big data, personal health information is a key resource for health care and clinical research. This study aimed to analyze the determinants and describe the measurement of the willingness to disclose personal health information.MethodsThe study conducted a systematic review of articles assessing willingness to share personal health information as a primary or secondary outcome. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis protocol. English and Italian peer-reviewed research articles were included with no restrictions for publication years. Findings were narratively synthesized.ResultsThe search strategy found 1,087 papers, 89 of which passed the screening for title and abstract and the full-text assessment.ConclusionNo validated measurement tool has been developed for willingness to share personal health information. The reviewed papers measured it through surveys, interviews, and questionnaires, which were mutually incomparable. The secondary use of data was the most important determinant of willingness to share, whereas clinical and socioeconomic variables had a slight effect. The main concern discouraging data sharing was privacy, although good data anonymization and the high perceived benefits of sharing may overcome this issue.