bluuebunny/crossref_metadata_2025_split huggingface dataset:
BSG 2024 IBD guidelines protocol (standard operating procedures)
Authors: Gordon Morris , Darie Ana-Maria , Sinopoulou Vasiliki , Verma Ajay , Bel Kok Klaartje , Patel Kamal V , Limdi Jimmy , Arebi Naila , Smith Philip , Din Shahida , Din Said , Shale Matthew , Subramanian Sreedhar , Pavlidis Polychronis , Cooney Rachel , McGonagle Dennis , A C S Wong Newton , Moran Gordon W 
Published: February 2023

IntroductionIn the past 5 years, there have been several advances in the management of inflammatory bowel disease (IBD). We aim for a new guideline to update the most recent guideline published in 2019. We present the prospective operating procedure and technical summary protocol in the manuscript.Methods‘Grading of Recommendations Assessment, Development and Evaluation’ (GRADE) will be followed in the development of the guideline, approach as laid out in the GRADE handbook, supported by the WHO. The guideline development group is formed by a variety of disciplines, across both primary and secondary care that took part in an online Delphi process and split into key areas. A final consensus list of thematic questions within a ‘patient, intervention, comparison, outcome’ format has been produced and agreed in the final phase of the Delphi process.There will be a detailed technical evidence review with source data including systematic reviews appraised with AMSATAR 2 tool (Assessment of multiple systematic reviews), randomised controlled trial data that will be judged for risk of bias with the Cochrane tool and observational studies for safety concerns assessed through the Robins-I tool. Based on the available evidence, some of the recommendations will be based on GRADE while others will be best practice statements.A full Delphi process will be used to make recommendations using online response systems.This set of procedures has been approved by the Clinical Services and Standards Committee, the British Society of Gastroenterology executive board and aligned with IBD UK standards.
How has the COVID-19 pandemic affected the utilisation of online consultation and face-to-face medical treatment? An interrupted time-series study in Beijing, China
Authors: Zhang Shan , Ma Chengyu 
Published: February 2023

ObjectiveThe COVID-19 pandemic has had a major impact on healthcare utilisation. This study aimed to quantify how the online and face-to-face utilisation of healthcare services changed during this time and thus gain insights into the planning of future healthcare resources during the outbreak of infectious diseases.DesignThis work is an interrupted time-series study.SettingMonthly hospital-grade healthcare-service data from 22 tertiary first-class public hospitals managed by the Beijing Hospital Authority and online-consultation data from GoodDoctor were used in this study.MethodsThis is an interrupted time-series study about the change in face-to-face and online healthcare utilisation before and after the COVID-19 outbreak. We compared the impact of COVID-19 on the primary outcomes of both face-to-face healthcare utilisation (outpatient and emergency visits, discharge volume) and online healthcare utilisation (online consultation volume). And we also analysed the impact of COVID-19 on the healthcare utilisation of different types of diseases.ResultsThe monthly average outpatient visits and discharges decreased by 36.33% and 35.75%, respectively, compared with those in 2019 in 22 public hospitals in Beijing. Moreover, the monthly average online consultations increased by 90.06%. A highly significant reduction occurred in the mean outpatients and inpatients, which dropped by 1 755 930 cases (p<0.01) and 5 920 000 cases (p<0.01), respectively. Online consultations rose by 3650 cases (p<0.05). We identified an immediate and significant drop in healthcare services for four major diseases, that is, acute myocardial infarction (−174, p<0.1), lung cancer (−2502, p<0.01), disk disease (−3756, p<0.01) and Parkinson’s disease (−205, p<0.01). Otherwise, online consultations for disk disease (63, p<0.01) and Parkinson’s disease (25, p<0.05) significantly increased. More than 1300 unique physicians provided online-consultation services per month in 2020, which was 35.3% higher than in 2019.ConclusionsObvious complementary trends in online and face-to-face healthcare services existed during the COVID-19 pandemic. Different changes in healthcare utilisation were shown for different diseases. Non-critically ill patients chose online consultation immediately after the COVID-19 lockdown, but critically ill patients chose hospital healthcare services first. Additionally, the volume of online physician services significantly rose as a result of COVID-19.
Mechanisms of chiropractic spinal manipulative therapy for patients with chronic primary low back pain: protocol for a mechanistic randomised placebo-controlled trial
Authors: Gevers-Montoro Carlos , Ortega-De Mues Arantxa , Piché Mathieu 
Published: February 2023

IntroductionChronic low back pain (CLBP) is a highly prevalent and disabling condition. Identifying subgroups of patients afflicted with CLBP is a current research priority, for which a classification system based on pain mechanisms was proposed. Spinal manipulative therapy (SMT) is recommended for the management of CLBP. Yet, little data are available regarding its mechanisms of action, making it difficult to match this intervention to the patients who may benefit the most. It was suggested that SMT may influence mechanisms associated with central sensitisation. Therefore, classifying patients with CLBP according to central sensitisation mechanisms may help predict their response to SMT.Methods and analysisThis protocol describes a randomised placebo-controlled trial aiming to examine which variables linked to central sensitisation may help predict the clinical response to SMT in a cohort of patients with CLBP. One hundred patients with chronic primary low back pain will be randomised to receive 12 sessions of SMT or placebo SMT over a 4-week period. Pain intensity and disability will be assessed as primary outcomes after completing the 4-week treatment (primary endpoint), and at 4-week and 12-week follow-ups. Baseline values of two pain questionnaires, lumbar pressure pain thresholds, concentrations of an inflammatory cytokine and expectations of pain relief will be entered as predictors of the response to SMT in a multiple regression model. Changes in these variables after treatment will be used in a second multiple regression model. The reference values of these predictors will be measured from 50 age and sex-matched healthy controls to allow interpretation of values in patients. Mixed analyses of variance will also be conducted to compare the primary outcomes and the predictors between groups (SMT vs placebo) over time (baseline vs post-treatment).Ethics and disseminationEthical approval was granted by the Fundación Jiménez Díaz Clinical Research Ethics Committee.Trial registration numberNCT05162924.
Influence of the COVID-19 pandemic and social media on the behaviour of pregnant and lactating women towards vaccination: a scoping review
Authors: De Brabandere Larissa , Hendrickx Greet , Poels Karolien , Daelemans Walter , Van Damme Pierre , Maertens Kirsten 
Published: February 2023

BackgroundPregnant women, foetuses and infants are at risk of infectious disease-related complications. Maternal vaccination is a strategy developed to better protect pregnant women and their offspring against infectious disease-related morbidity and mortality. Vaccines against influenza, pertussis and recently also COVID-19 are widely recommended for pregnant women. Yet, there is still a significant amount of hesitation towards maternal vaccination policies. Furthermore, contradictory messages circulating social media impact vaccine confidence.ObjectivesThis scoping review aims to reveal how COVID-19 and COVID-19 vaccination impacted vaccine confidence in pregnant and lactating women. Additionally, this review studied the role social media plays in creating opinions towards vaccination in these target groups.Eligibility criteriaArticles published between 23 November 2018 and 18 July 2022 that are linked to the objectives of this review were included. Reviews, articles not focusing on the target group, abstracts, articles describing outcomes of COVID-19 infection/COVID-19 vaccination were excluded.Sources of evidenceThe PubMed database was searched to select articles. Search terms used were linked to pregnancy, lactation, vaccination, vaccine hesitancy, COVID-19 and social media.Charting methodsIncluded articles were abstracted and synthesised by one reviewer. Verification was done by a second reviewer. Disagreements were addressed through discussion between reviewers and other researchers.ResultsPregnant and lactating women are generally less likely to accept a COVID-19 vaccine compared with non-pregnant and non-nursing women. The main reason to refuse maternal vaccination is safety concerns. A positive link was detected between COVID-19 vaccine willingness and acceptance of other vaccines during pregnancy. The internet and social media are identified as important information sources for maternal vaccination.Discussion and conclusionVaccine hesitancy in pregnant and lactating women remains an important issue, expressing the need for effective interventions to increase vaccine confidence and coverage. The role social media plays in vaccine uptake remains unclear.
Protocol for Multi-modality MEdical imaging sTudy bAsed on KaiLuan Study (META-KLS): rationale, design and database building
Authors: Sun Jing , Hui Ying , Li Jing , Zhao Xinyu , Chen Qian , Li Xiaoshuai , Wu Ning , Xu Mingze , Liu Wenjuan , Li Rui , Zhao Pengfei , Wu YunTao , Xing Aijun , Shi Huijing , Zhang Shun , Liang Xiaoliang , Wang Yongxin , Lv Han , Wu Shouling , Wang Zhenchang 
Published: February 2023

IntroductionMulti-modality medical imaging study, especially brain MRI, greatly facilitates the research on subclinical brain disease. However, there is still a lack of such studies with a wider age span of participants. The Multi-modality MEdical imaging sTudy bAsed on KaiLuan Study (META-KLS) was designed to address this issue with a large sample size population.Methods and analysisWe aim to enrol at least 1000 subjects in META-KLS. All the participants without contraindications will perform multi-modality medical imaging, including brain MRI, retinal fundus photograph, fundus optical coherence tomography (OCT) and ultrasonography of the internal carotid artery (ICA) every 2–4 years. The acquired medical imaging will be further processed with a standardised and validated workflow. The clinical data at baseline and follow-up will be collected from the KaiLuan Study. The associations between multiple risk factors and subclinical brain disease are able to be fully investigated. Researches based on META-KLS will provide a series of state-of-the-art evidence for the prevention of neurological diseases and common chronic diseases.Ethics and disseminationThe Kailuan Study and META-KLS have been approved by the Medical Ethics Committee of Kailuan General Hospital (IRB number: 2008 No. 1 and 2021002, respectively). Written informed consent will be acquired from each participant. Results are expected to be published in professional peer-reviewed journals beginning in 2023.Trial registration numberNCT05453877.
Healthcare waste management practice and its predictors among health workers in private health facilities in Ilu Aba Bor Zone, Oromia region, South West Ethiopia: a community-based cross-sectional study
Authors: Tilahun Degemegn , Donacho Dereje Oljira , Zewdie Asrat , Kera Abeza Mitiku , Haile Degefa Gutama 
Published: February 2023

ObjectivesA lack of safe healthcare waste management (HCWM) practice poses a risk to healthcare staff, patients and communities. In low-income countries like Ethiopia, studies on the level of safe HCWM practices in private healthcare facilities are limited. This study was designed to assess the level of good HCWM practice and associated factors among health workers in private health facilities.MethodsAn institution-based cross-sectional study was conducted in the Ilu Aba Bor zone, South West Ethiopia. A random sample of 282 health workers from 143 private health facilities was included in the study. Data were collected using a pretested structured questionnaire that included sociodemographic characteristics, healthcare factors, knowledge assessment and an observation checklist adapted from WHO guidelines. The collected data were entered into EpiData V.3.1 and analysed with SPSS V.25.0. Multivariable logistic regression analysis was used to identify factors associated with HCWM practice. Variables with a p value of <0.05 at 95% CI were declared significant.ResultsMore than half (58.7%) of private-sector health workers had good HCWM practice. The presence of the HCWM committee (adjusted OR (AOR)=9.6, 95% CI 4.5 to 20.6), designated healthcare waste storage site (AOR=3.0, 95% CI 1.5 to 6.5), reading the HCWM manual (AOR=4.4, 95% CI 2.2 to 9.0) and having good knowledge of HCWM (AOR=2.6, 95% CI 1.06 to 6.15) were factors associated with good HCWM practice.ConclusionAbout three out of five health workers in private healthcare facilities were practising good HCWM. The presence of an HCWM committee, waste management utilities, reading HCWM guidelines and knowledge of health workers were the identified factors. Health workers should read guidelines to improve their knowledge, and the presence of committees and waste management utilities in private clinics should be followed to ensure compliance with safe HCWM practice.
Subcutaneous fast-acting insulin analogues, alone or in combination with long-acting insulin, versus intravenous regular insulin infusion in patients with diabetic ketoacidosis: protocol for an updated systematic review and meta-analysis of randomised trials
Authors: Lim Beng Leong , Lee Wei Feng , Lee Berlin , Chung Yan Ee Lynette , Loo Kee Vooi 
Published: February 2023

IntroductionDiabetic ketoacidosis (DKA) is traditionally managed using intravenous regular insulin infusion (RII) in intensive care unit (ICU)/high dependency unit (HDU). Subcutaneous fast-acting insulin analogues (FAIAs) may help to manage DKA outside ICU/HDU. Furthermore, combining subcutaneous long-acting insulin (LAI) with subcutaneous FAIAs may accelerate ketoacidosis resolution. The latest (2016) Cochrane review was inconclusive regarding subcutaneous FAIAs versus intravenous RII in DKA. It was limited by small sample sizes, unclear risk of bias (RoB) in primary trials and did not examine subcutaneous FAIAs with subcutaneous LAI versus intravenous RII in DKA. We report the protocol for an updated meta-analysis on the safety and benefits of subcutaneous FAIAs with/without subcutaneous LAI versus intravenous RII in DKA.Methods and analysisWe will search Medline, Embase, CINAHL and Cochrane Library, from inception until December 2022, without language restrictions, for randomised trials on subcutaneous FAIAs with/without subcutaneous LAI versus intravenous RII in DKA. We also search ClinicalTrials.gov, ClinicalTrialsRegister.eu and reference lists of included trials. Primary outcomes include all-cause in-hospital mortality, time to DKA resolution, in-hospital DKA recurrence and hospital readmission for DKA post-discharge. Secondary outcomes include resource utilisation and patient satisfaction. Safety outcomes include important complications of DKA and insulin. Reviewers will extract data, assess overall RoB and quality of evidence using Grading of Recommendations, Assessment, Development and Evaluation. We will assess statistical heterogeneity by visually inspecting forest plots and the I2statistic. We will synthesise data using the random-effects model. Predefined subgroup analyses are: mild versus moderate versus severe DKA; age <20 vs ≥20 years; pregnant versus non-pregnant; infective versus non-infective DKA precipitating cause; subcutaneous FAIAs alone versus subcutaneous FAIAs and subcutaneous LAI; and high versus low overall RoB. We will also perform trial sequential analysis for primary outcomes.Ethics and disseminationEthics board approval is not required. Results will be disseminated through publication in a peer-reviewed journal.PROSPERO registration numberCRD42022369518.
Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron
Authors: Johnstone Erik V. , Mayordomo Natalia , Mausolf Edward J. 
Published: February 2023

AbstractNew modes of production and supply of short-lived radioisotopes using accelerators are becoming attractive alternatives to the use of nuclear reactors. In this study, the use of a compact accelerator neutron source (CANS) was implemented to explore the production of 99mTc and 101Tc. Irradiations were performed with neutrons generated from a 16.5 MeV cyclotron utilising the 18O(p, n)18F reaction during routine 18F-fluorodeoxyglucose (FDG) production in a commercial radiopharmacy. Natural molybdenum targets in metal form were employed for the production of several Tc isotopes interest via (n, γ) reactions on 98Mo and 100Mo. The production of 99mTc and 101Tc under these conditions is considered and discussed.
BISTABILITY AND TRISTABILITY IN A PREDATOR–PREY MODEL WITH STRONG ALLEE EFFECT IN PREY
Authors: KUMBHAKAR RUMA , PAL SAHEB , PAL NIKHIL , TIWARI PANKAJ KUMAR 
Published: February 2023

Understanding the Allee effect on endangered species is crucial for ecological conservation and management as it highly affects the extinction of a population. Due to several ecological mechanisms accounting for the Allee effect, it is necessary to study the dynamics of a predator–prey model incorporating this phenomenon. In 1999, Cosner et al. [Effects of spatial grouping on the functional response of predators, Theor Popul Biol 56:65–75, 1999] derived a new kind of functional response by considering spatially grouped predators. This paper deals with the dynamical behavior of a predator–prey system with functional response proposed by Cosner et al., and the growth of the prey population suffers a strong Allee effect. We find that the system undergoes various types of bifurcations such as Hopf bifurcation, saddle-node bifurcation, and Bogdanov–Takens bifurcation. We also observe that the model exhibits bistability and two different types of tristability phenomena. Our findings reveal that for such a kind of multistability in ecological systems, the initial population size plays a crucial role and also impacts the system’s state in the long term.
A Review on Tools, Mechanics, Benefits, and Challenges of Gamified Software Testing
Authors: Fulcini Tommaso , Coppola Riccardo , Ardito Luca , Torchiano Marco 
Published: February 2023

Gamification is an established practice in Software Engineering to increase effectiveness and engagement in many practices. This manuscript provides a characterization of the application of gamification to the Software Testing area. Such practice in fact reportedly suffers from low engagement by both personnel in industrial contexts and learners in educational contexts. Our goal is to identify the application areas and utilized gamified techniques and mechanics, the provided benefits and drawbacks, as well as the open challenges in the field. To this purpose, we conducted a Multivocal Literature Review to identify white and grey literature sources addressing gamified software testing.
We analyzed 73 contributions and summarized the most common gamified mechanics, concepts, tools, and domains where they are mostly applied. We conclude that gamification in software testing is mostly applied to the test creation phase with simple white-box unit or mutation testing tools and is mostly used to foster good behaviors by promoting the testers’ accomplishment. Key research areas and main challenges in the field are: careful design of tailored gamified mechanics for specific testing techniques; the need for technological improvements to enable crowdsourcing, cooperation, and concurrency; the necessity for empirical and large-scale evaluation of the benefits delivered by gamification mechanics.
Parallel Peeling of Bipartite Networks for Hierarchical Dense Subgraph Discovery
Authors: Lakhotia Kartik , Kannan Rajgopal , Prasanna Viktor 
Published: February 2023

Wing
and
Tip
decomposition are motif-based analytics for bipartite graphs that construct a hierarchy of butterfly (2,2-biclique) dense edge and vertex induced subgraphs, respectively. They have applications in several domains, including e-commerce, recommendation systems, document analysis, and others.

Existing decomposition algorithms use a bottom-up approach that constructs the hierarchy in an increasing order of the subgraph density. They iteratively select the edges or vertices with minimum butterfly count
peel
, i.e., remove them along with their butterflies. The amount of butterflies in real-world bipartite graphs makes bottom-up peeling computationally demanding. Furthermore, the strict order of peeling entities results in a large number of sequentially dependent iterations. Consequently, parallel algorithms based on bottom up peeling incur heavy synchronization and poor scalability.

In this article, we propose a novel Parallel Bipartite Network peelinG (PBNG) framework that adopts a two-phased peeling approach to relax the order of peeling, and in turn, dramatically reduce synchronization. The first phase divides the decomposition hierarchy into few partitions and requires little synchronization. The second phase concurrently processes all partitions to generate individual levels of the hierarchy and requires no global synchronization. The two-phased peeling further enables batching optimizations that dramatically improve the computational efficiency of PBNG.

We empirically evaluate PBNG using several real-world bipartite graphs and demonstrate radical improvements over the existing approaches. On a shared-memory 36 core server, PBNG achieves up to 19.7× self-relative parallel speedup. Compared to the state-of-the-art parallel framework P
ar
B
utterfly
, PBNG reduces synchronization by up to 15,260× and execution time by up to 295×. Furthermore, it achieves up to 38.5× speedup over state-of-the-art algorithms specifically tuned for wing decomposition. Our source code is made available at
https://github.com/kartiklakhotia/RECEIPT
.