bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Using Pre-Questioning to Improving the Students’ Reading Comprehension Skills to the Tenth Grade Students of SMA Negeri 2 Padangsidimpuan
Authors: Sari Siti Meutia , Harahap Tinur Rahmawati , Sinaga Wanro , Tambunan Elissa Evawani 
Published: February 2023

This research is mainly conducted by the writer in order to know that there is a significant effect of using the pre-questioning to improving the students’ reading comprehension skills to the tenth grade students’ of SMA Negeri 2 Padangsidimpuan or not. The number of the sample is 52 students. In this research the writer applies the cluster sampling. And as the instrument for collecting the data the writer uses the questioners for variable X and the essay test for variable Y. For getting the needed data, the writer applies the library and field research. The method of research is experiment method, that is the writes find out the different of students’ score before-after using pre-questioning method.	Based on the result of research can be known the students’ mean score in pre-test is 80.76. After treatment the students’ mean score increase into 89.04. After collecting the needed the data, the next step which is done by the writer is analyzing it by using statistical analysis. The statistical formulation which is used in this research is the formulation of Pearson’s Product Moment Correlation (rxy). After analyzing the collected data, it has been got that the value of correlation (rxy), that is 0.945. By consulting this value to the table interpretation given before, it is known that this value can be categorized into the very high correlation category. It means that there is a significant effect of using the pre-questioning to improving the students’ reading comprehension skills to the tenth grade students’ of SMA Negeri 2 Padangsidimpuan. The hypothesis of this research accepted.
STUDENTS’ DIFFICULTIES IN LISTENING COMPREHENSION
Authors: Anisah Lina , Basri Laode , Riskawati Riskawati 
Published: February 2023

Abstract This research was conducted to investigate students’ difficulties in listening comprehension and to find out the causes of students’ difficulties in listening comprehension. The design of this research was a case study. In conducting this research, the researcher took class XI IPA 4 of MAN 1 Kolaka as a subject of the research. To collect the data, the researcher used test, questionnaire and interview as instruments. Finally, based on the researcher’s investigation, the level of students’ difficulty in listening comprehension is classified into middle level, they were, student difficult to concentrate with noise sound (98%), to recognize the words the way they were pronounce (88%), to understand spoken text when speaker spoke too fast (83%), unclear sounds resulting from a poor-quality CD player (81%), to listen to English without transcription (80%), to understand well when the speaker spoke with a variety of accents (80%). Some causes of students’ difficulties in listening comprehension were noisy situations in class and environment, students could not match the sounds they heard with any script in their long-term memory, students limited short-term memory, text/passage was recorded while there were noises around or the cassette was used for such a long time, students have limited vocabulary, and unfamiliar accent. Keyword: Analysis, Difficulties in Listening Comprehension, Listening Comprehension.
USING SHOW AND TELL METHOD IN IMPROVING THE STUDENTS’ VOCABULARY MASTERY TO THE EIGHTH GRADE STUDENTS OF SMP NEGERI 1 BATANG NATAL
Authors: Sari Siti Meutia , Harahap Tinur Rahmawati , Parpol Parpol , Tambunan Elissa Evawani 
Published: February 2023

The purpose of this study is to knowwhether using Show and tell method in teaching can improve the students’ vocabulary mastery or not. This technique can improve and increase student’s ability to learn the target language and make them enjoy in the teaching learning process. It supposes to motivate students to learn English actively by using show and tell method. Students also are encouraged to get long memorizing of the words and their meaning. The method that is used in this research is the classroom action research.For getting the needed data, the writer applies the library and field research. The library research is applied based on the needs of the books as the sources of theories and informations, and the field research is applied based on the need of data from the field, in this case from the SMP Negeri 1 Batang Natal. And as the instrument for collecting the data the writer uses the written test. To the result of implementing classroom action research inthe eleventh grade students of SMP Negeri 1 Batang Natal in 2020 - 2021 academic year, it showed a great improvement in which the mean score of students in pretest is 61.03, whereas in post test 1 is 68.60 and in post test 2 are80.37. Besides, the students’ score percentage in the pretest is 8.82%, from posttest 1 is 31.69 % and 82.35 % from post test of students who have passed the KKM.Next, the result of the students’ score improvement from pretest to posttest 1is 8.82 %, and from pretest to posttest 2 is 31.69%. The percentage got from the result of post – test 2 has achieved the criteria of successSo that, it can be concluded thatthere is a significant improvement of the students’ vocabulary mastery after they are taught by using Show and tell method”.And it can be stated that the formulated hypothesis is accepted.
IMPLEMENTATION OF THE ADIWIYATA-BASED CURRICULUM IN ENGLISH LEARNING ACTIVITY AT MTsN 1 SIDOARJO
Authors: Alilah Nur , Chodijah Siti , Ainisshifa Nabila , Santana Affan Heryana , Susanti Effi , Fitriah Fitriah 
Published: February 2023

This research is focused on the implementation of the Adiwiyata-based curriculum in English learning at MTsN 1 Sidoarjo. The researcher applies a qualitative descriptive method which aims to determine the implementation of the Adiwiyata school program and its implementation in learning English. Data collection technique that is used in this study is qualitative data which are gained from observation,interview,and field note. Furthermore, the qualitative data are analyzed by: assembling the data, coding the data, comparing the data, building interpretations, and reporting the outcomes. The result of the research shows that (a) the Adiwiyata-based curriculum adds or inserts indicators that are integrated with the environment; (b) The procedure for developing adiwiyata-based curriculum is the same as in the general curriculum; (c) Implementation of the adiwiyata-based curriculum, starting from the preparation of lesson plans to learning activities and other activities related to the environment; (d) The purpose of implementing the Adiwiyata-based curriculum at MTsN 1 Sidoarjo. Hence, the findings reveal that implementation of the Adiwiyata-based curriculum in English learning at MTsN 1 Sidoarjo was successfully viewed from a certain perspective.
Os sentidos e significados das práticas pedagógicas no uso da música e da dança na educação infantil
Authors: Silva Jéssica Maria dos Santos , Nascimento Pedro Antonio Santos do , Braga Osmar Rufino 
Published: February 2023

O artigo, que é resultado de uma pesquisa realizada em 2020, junto a uma escola de educação infantil, situada no município de Parnaíba (PI), tem como objetivo apresentar uma análise acerca dos sentidos e significados das práticas pedagógicas, desenvolvidas por educadores, que trabalham com a música e a dança na escola de educação infantil. O estudo qualitativo, usou uma abordagem metodológica do tipo etnográfico. O trabalho situa-se no contexto das investigações acerca da educação infantil, com destaque para um tema que está ligado ao eixo temático da cultura, linguagem e interação social. As conclusões das análises apontam para a existência de concepções e práticas que focalizam a música e a dança apenas como instrumento de relaxamento, forma de entretenimento, “quebra gelo” e artifício e não como dispositivos centrais e estratégicos no desenvolvimento integral da criança.
Cara memasarkan produk UMKM pada masa COVID-19 melalui media sosial
Authors: Widiawati Kadek , Kalfika Anggria Wardani Kadek Devi , Supriyadinata Gorda A.A. Ngr. Eddy 
Published: February 2023

Melemahnya ekonomi karena adanya pandemi COVID-19 dapat berdampak langsung terhadap UMKM Roti yang ada di Desa Padangsambian, Kecamatan Denpasar Barat. Hal tersebut menyebabkan permintaan dan pendapatan berkurang. Solusi yang dapat dilakukan untuk mengatasi permasalahan tersebut dengan memberikan edukasi dan pelatihan terkait dengan penggunaan dan pembuatan akun digital marketingsebagai alat untuk memasarkan produk UKM Roti di Desa Padangsambian. Edukasi yang diberikan berupa pelatihan mengenai cara memasarkan produk di media social, e-commerce, dan website dengan tepat dan benar. Program lain yang diberikan yaitu dengan asistensi pembuatan akun e-commerce dan digital marketingyang lainnya yang akan digunakan untuk promosi.Platform yang dipilih yaitu media yang memiliki jejaring pengguna besar di Indonesia, yaitu Facebook, Intagram, dan Shopee Food. Metode yang digunakan dalam kegiatan ini adalah pelatihan dan pendampingan. Hasil dari kegiatan ini adalahÂ terbentuknya akun digital marketingseperti Facebook, Instagram, dan juga Shopee Food yang digunakan untuk mempromosikan hasil produksi dari UMKM Roti sehingga dapat meningkatkan pendapatan penjualan hasil produksi, hasil pengabdian ini sangat bermanfaat bagi UMKM Roti untuk mempertahankan usahanya di tengah pandemi COVID-19 saat ini. Sebagai tindak lanjut, diharapkan pemerintah desa setempat bekerja sama dengan pihak ketiga memberikan pelatihan pembuatan konten marketing, sehingga akun yang telah dibuat dapat dimaksimalkan untuk memasarkan produk UKM Roti.
TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS
Authors: DOĞAN Muhammed Fatih , ÇİFTÇİ Oisman , BAŞAK TÜRKMEN Neşe , ÇETİN Aslı , ZENGİN Münevver Nazlıcan , ÇİFTÇİ Bedriye 
Published: February 2023

Objective: The aim of the study was to investigate the preventive effects of Taurine against 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD)-induced organ damage in rats. The environmental toxin TCDD has a high toxicity in animal and human tissues. Taurine is an amino acid found in organ cells that has and antioxidant properties and anti-inflammatory. As a result, the potential preventive effect of taurine on oxidative stress and organ damage caused by TCDD was investigated in rat liver and kidney tissues by measuring glutathione (GSH), superoxide dismutase (SOD) activity, and thiobarbituric acid reactive substances (TBARS) levels.
Material and Method: Adult male Wistar rats (250-300 g, 12-13 weeks, n = 32) were randomly allocted into four groups (n = 8/group): Control, TCDD, TAU, and TCDD+TAU. TCDD and/or taurine were administered via gavage in doses of 2 μg/kg/week and 200 mg/kg/day, respectively.
Result and Discussion: The results showed that TCDD caused oxidative stress in the liver and kidney tissues of rats by decreasing the levels of GSH and SOD activity and increasing the levels of TBARS. Taurine treatment significantly reduced TBARS levels (p
DEVELOPMENT AND OPTIMIZATION OF INDOMETHACIN NANOSUSPENSIONS USING DESIGN OF EXPERIMENT APPROACHES
Authors: TOPAL Gizem Rüya , KÖSE ÖZKAN Cansel , ÖZKAN Yalçın 
Published: February 2023

ABSTRACT
Objective: In this study, it was aimed to prepare nanosuspensions that contains Indomethacin which is a BCS class II drug. To assess the cumulative impact of the chosen variables on the nanosuspension properties, a 34 factorial design was applied and particle size and distributions were examined.
Material and Method: In the study, the solvent/antisolvent method was used in the preparation of the suspensions. 34 factorial design. Design-Expert software was used for evaluation of the prepared formulations in order to obtain the best formulation. PVA ratio, PVA molecular weight, solvent/antisolvent ratio, and ethanol/PEG ratio were used as independent design parameters, and their effects on particle size and distribution were examined.
Result and Discussion: Nanosuspensions were successfully prepared by the solvent/antisolvent method. Particle size and polydispersity index of the nanosuspensions were found to be affected by both molecular weight and percentage of PVA in the anti-solvent phase (p ˂ 0.05). 0.2% PVA; molecular weight of 31 000 for PVA and the solvent-antisolvent ratio as 3:50 were found to be the optimal parameters for the nanosuspension formulations. The particle size and polydispersity of optimum formulation was found 301.5 ± 31.1 nm and 0.159 ± 0.035, respectively.

Keywords: Factorial design, indomethacin, nanosuspension, solvent/antisolvent method
RPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS DETERMINATION OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS IN TABLET FORMULATIONS
Authors: ÇUBUK DEMİRALAY Ebru , ÜRER Fatma , ÜSTÜN Zehra , DALDAL Yaşar Doğan 
Published: February 2023

Objective: Selective serotonin reuptake inhibitor (SSRIs) compounds are the most used compounds in the treatment of depression. The determination of chromatographic separation and quantitative determination of these compounds is very important in the clinical use of these compounds and the success of biopharmaceutical studies. For this reason, this study, it was aimed to optimize the chromatographic conditions for the quantitative determination of SSRIs in tablet formulation by Reversed phase liquid chromatography method.
Material and Method: The optimum separation condition for the studied compounds was determined based on the relationship between the retention values of the compounds and the pH and the content of the mobile phase. Chromatographic determination was made on the X Terra C18 column (250 x 4.6 mm I.D., 5 μm), which is widely used for the determination of hybrid-based and basic compounds. The validation of the developed method was carried out based on the parameters of linearity, precision, and accuracy.
Result and Discussion: The developed and validated method was successfully applied for the determination of active ingredients in the tablet dosage form. The experimental results of the amount of studied SSRIs in selected commercial tablets are in good agreement with the label claims. The calculated percent recoveries show that the sample preparation techniques developed for the quantification of the compounds studied are not affected by interferences. The evaluation of the obtained results showed that the developed method is suitable for the routine use of studied compounds.
Maintaining deep roots
Authors: Grummell Bernie 
Published: February 2023

This article explores on the formative influence of adult popular education in the evolution and continued ethos of adult literacy education in the Republic of Ireland. Freire’s work has been influential within Irish adult education and community development, informed by Freirean practices of learner-centredness, experiential learning and group learning. This stands in contrast to Further Education and Training system in which the adult literacy services are based, which has become increasingly professionalised in recent years, susceptible to the ideological values and practices of performativity. The article analyses the findings of research reports on adult literacy which used a mixed methods approach. They reveal how the adult literacy sector holds important spaces for educators to counteract systemic pressures of performativity as they work with learners and their communities through the ethos and pedagogies of adult education, but this is constrained in its radical transformative possibilities.
Bibliometric and visualization analysis of stem cell therapy for meniscal regeneration from 2012 to 2022
Authors: Yang Zhen , Fan Zejun , Wang Du , Li Hui , He Zihao , Xing Dan , Lin Jianhao 
Published: February 2023

Background: Meniscus injuries, a common joint disease caused by long-term wear, trauma and inflammation, usually cause chronic dysfunction and pain in the joint. Current clinical surgeries mainly aim to remove the diseased tissue to alleviate patient suffering instead of helping with meniscus regeneration. As an emerging treatment, stem cell therapy has been verified to facilitate meniscus regeneration effectively. The purpose of this study is to investigate the publication conditions of stem cell therapy for meniscal regeneration and to visualize the research trends and frontiers.Methods: Relevant publications relevant to stem cells for meniscal regeneration was retrieved SCI-Expanded of the Web of Science database from 2012 to 2022. Research trends in the field were analysed and visualized by CiteSpace and VOSviewer.Results: A total of 354 publications were collected and analysed. The United States contributed the largest number of publications (118, 34.104%). Tokyo Medical Dental University has contributed the largest number of publications (34) among all full-time institutions. Stem cell research therapy has published the largest number of researches on stem cells for meniscal regeneration (17). SEKIYA. I contributed the majority of publications in this field (31), while Horie, M was the most frequently cited authors (166). #1 tissue engineering, #2 articular cartilage, #3 anterior cruciate ligament, #4 regenerative medicine, #5 scaffold are the chief keywords. This indicates that the current research hotspot has been transformed from basic surgical research to tissue engineering.Conclusion: Stem cell therapy is a promising therapeutic method for meniscus regeneration. This is the first visualized and bibliometric study to thoroughly construct the development trends and knowledge structure in the research field of stem cell therapy for meniscal regeneration in the past 10 years. The results thoroughly summarize and visualize the research frontiers, which will shed light on the research direction of stem cell therapy for meniscal regeneration.
Effects of antibiotics on the in vitro expression of tetracycline-off constructs and the performance of Drosophila suzukii female-killing strains
Authors: Yan Ying , Hosseini Bashir , Scheld Annemarie , Pasham Srilakshmi , Rehling Tanja , Schetelig Marc F. 
Published: February 2023

Genetic control strategies such as the Release of Insects Carrying a Dominant Lethal (RIDL) gene and Transgenic Embryonic Sexing System (TESS) have been demonstrated in the laboratory and/or deployed in the field. These strategies are based on tetracycline-off (Tet-off) systems which are regulated by antibiotics such as Tet and doxycycline (Dox). Here, we generated several Tet-off constructs carrying a reporter gene cassette mediated by a 2A peptide. Different concentrations (0.1, 10, 100, 500, and 1,000 μg/mL) and types (Tet or Dox) of antibiotics were used to evaluate their effects on the expression of the Tet-off constructs in the Drosophila S2 cells. One or both of the two concentrations, 100 and 250 μg/mL, of Tet or Dox were used to check the influence on the performances of a Drosophila suzukii wild-type strain and female-killing (FK) strains employing TESS. Specifically, the Tet-off construct for these FK strains contains a Drosophila suzukii nullo promoter to regulate the tetracycline transactivator gene and a sex-specifically spliced pro-apoptotic gene hidAla4 to eliminate females. The results suggested that the in vitro expression of the Tet-off constructs was controlled by antibiotics in a dose-dependent manner. ELISA experiments were carried out identifying Tet at 34.8 ng/g in adult females that fed on food supplemented with Tet at 100 μg/mL. However, such method did not detect Tet in the eggs produced by antibiotic-treated flies. Additionally, feeding Tet to the parents showed negative impact on the fly development but not the survival in the next generation. Importantly, we demonstrated that under certain antibiotic treatments females could survive in the FK strains with different transgene activities. For the strain V229_M4f1 which showed moderate transgene activity, feeding Dox to fathers or mothers suppressed the female lethality in the next generation and feeding Tet or Dox to mothers generated long-lived female survivors. For the strain V229_M8f2 which showed weak transgene activity, feeding Tet to mothers delayed the female lethality for one generation. Therefore, for genetic control strategies employing the Tet-off system, the parental and transgenerational effects of antibiotics on the engineered lethality and insect fitness must be carefully evaluated for a safe and efficient control program.
Meta-analysis of the characteristic expression of circulating microRNA in type 2 diabetes mellitus with acute ischemic cerebrovascular disease
Authors: Hu Feifei , Liu Lei , Liu Zhijian , Cao Mingfeng , Li Guanghong , Zhang Xinhuan 
Published: February 2023

ObjectiveTo comprehensively evaluate the characteristics of the circulating microRNA expression profile in type 2 diabetic patients with acute ischemic cerebrovascular disease by systematic evaluation and meta-analysis.MethodsThe literatures up to March 2022 related to circulating microRNA and acute ischemic cerebrovascular disease in type 2 diabetes mellitus were searched and screened from multiple databases. The NOS quality assessment scale was used to evaluate methodological quality. Heterogeneity tests and statistical analyses of all data were performed by Stata 16.0. The differences in microRNA levels between groups were illustrated by the standardized mean difference (SMD) and 95% confidence interval (95% CI).ResultsA total of 49 studies on 12 circulating miRNAs were included in this study, including 486 cases of type 2 diabetes complicated with acute ischemic cerebrovascular disease and 855 controls. Compared with the control group (T2DM group), miR-200a, miR-144, and miR-503 were upregulated and positively correlated with acute ischemic cerebrovascular disease in type 2 diabetes mellitus patients. Their comprehensive SMD and 95% CI were 2.71 (1.64~3.77), 5.77 (4.28~7.26) and 0.73 (0.27~1.19), respectively. MiR-126 was downregulated and negatively correlated with acute ischemic cerebrovascular disease in type 2 diabetes mellitus patients, its comprehensive SMD and 95% CI were -3.64 (-5.56~-1.72).ConclusionIn type 2 diabetes mellitus patients with acute ischemic cerebrovascular disease, the expression of serum miR-200a, miR-503, plasma and platelet miR-144 was upregulated and the expression of serum miR-126 was downregulated. It may have diagnostic value in the early identification of type 2 diabetes mellitus with acute ischemic cerebrovascular disease.