bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting the formation of different tissue types during Achilles tendon healing using mechanoregulated and oxygen-regulated frameworks
Authors: Notermans Thomas , Isaksson Hanna 
Published: December 2022

AbstractDuring Achilles tendon healing in rodents, besides the expected tendon tissue, also cartilage-, bone- and fat-like tissue features have been observed during the first twenty weeks of healing. Several studies have hypothesized that mechanical loading may play a key role in the formation of different tissue types during healing. We recently developed a computational mechanobiological framework to predict tendon tissue production, organization and mechanical properties during tendon healing. In the current study, we aimed to explore possible mechanobiological related mechanisms underlying formation of other tissue types than tendon tissue during tendon healing. To achieve this, we further developed our recent framework to predict formation of different tissue types, based on mechanobiological models established in other fields, which have earlier not been applied to study tendon healing. We explored a wide range of biophysical stimuli, i.e., principal strain, hydrostatic stress, pore pressure, octahedral shear strain, fluid flow, angiogenesis and oxygen concentration, that may promote the formation of different tissue types. The numerical framework predicted spatiotemporal formation of tendon-, cartilage-, bone- and to a lesser degree fat-like tissue throughout the first twenty weeks of healing, similar to recent experimental reports. Specific features of experimental data were captured by different biophysical stimuli. Our modeling approach showed that mechanobiology may play a role in governing the formation of different tissue types that have been experimentally observed during tendon healing. This study provides a numerical tool that can contribute to a better understanding of tendon mechanobiology during healing. Developing these tools can ultimately lead to development of better rehabilitation regimens that stimulate tendon healing and prevent unwanted formation of cartilage-, fat- and bone-like tissues.
A National Strategy for Preventing Substance and Opioid Use Disorders Through Evidence-Based Prevention Programming that Fosters Healthy Outcomes in Our Youth
Authors: Fishbein Diana H. , Sloboda Zili 
Published: December 2022

AbstractThe recently released National Drug Control Strategy (2022) from the White House Office of National Drug Control Policy (ONDCP) lays out a comprehensive plan to, not only enhance access to treatment and increase harm reduction strategies, but also increase implementation of evidence-based prevention programming at the community level. Furthermore, the Strategy provides a framework for enhancing our national data systems to inform policy and to evaluate all components of the plan. However, not only are there several missing components to the Strategy that would assure its success, but there is a lack of structure to support a national comprehensive service delivery system that is informed by epidemiological data, and trains and credentials those delivering evidence-based prevention, treatment, and harm reduction/public health interventions within community settings. This paper provides recommendations for the establishment of such a structure with an emphasis on prevention. Systematically addressing conditions known to increase liability for behavioral problems among vulnerable populations and building supportive environments are strategies consistently found to avert trajectories away from substance use in general and substance use disorders (SUD) in particular. Investments in this approach are expected to result in significantly lower rates of SUD in current and subsequent generations of youth and, therefore, will reduce the burden on our communities in terms of lowered social and health systems involvement, treatment needs, and productivity. A national strategy, based on strong scientific evidence, is presented to implement public health policies and prevention services. These strategies work by improving child development, supporting families, enhancing school experiences, and cultivating positive environmental conditions.
Heat projections and mortgage characteristics: evidence from the USA
Authors: Baranyai Eszter , Banai Ádám 
Published: December 2022

Abstract
Climate change is increasingly acknowledged as a fundamental risk to the stability of the financial system. The linkage between residential mortgage lending and local heatwave projections has hitherto received little attention in the climate finance discourse despite recognition of the detrimental effects of extreme heat on economic output measures. Through economic, demographic and other channels, future climate conditions can affect the housing market and, thus, the residential mortgage market. Moreover, the potential for contagion is high considering US residential mortgages’ key role in financial cycles and cross-border effects. First, our paper furthers conceptual and empirical understandings of the nexus between future extreme heat and lenders’ credit risk. Second, for the contiguous US states, we show that interest rates are higher and loan terms are shorter in areas forecast to experience a larger increase in the number of hot days over the coming decades after controlling for a range of factors. Rate spreads are higher still in areas where the number of hot days is projected to be extreme. It is lending from non-banks, rather than banks, that appears sensitive to the changing climate.
Linear and Non Linear Recognition for the Sorption of 60Co and 152+154Eu Radionuclides onto Bio CuO Nanocomposite
Authors: Moussa S. I. , Mekawy Zakaria A. , Dakroury G. A. , Mousa Abeer M. , Allan K. F. 
Published: December 2022

AbstractA novel nanocomposite was prepared by hybridizing polyacrylic acid/maleic acid with nano copper oxide (PAACMA/CuO) for the sorption of 60Co (II) and 152+154Eu (III) radionuclides from an aqueous solution. Nano-CuO was biochemically produced by hydrolysing its salt in the presence of the Aspergillus terreus fungus. The PAACMA/CuO nanocomposite was characterized using a variety of analytical techniques. The optimum sorption conditions (pH  4.5 for 60Co and pH  3.53 for 152+154Eu, 24 h of equilibrium time at 20 oC) were applied. The kinetic mechanism of the sorption reaction was controlled by pseudo second order based on residual charts, coefficient of determination (R2), and corrected Akaike information Criterion (AICc). The sorption reaction mechanism was controlled by Langmuir model for linear regression using the coefficient of determination and the Dubinin-Radushkevich D-R model for the AICc and residual plots error functions. The reaction mechanism throughout non-linear regression was controlled by the D-R model due to the coefficient of determination, AICc, and residual charts. The PAACMA/CuO nanocomposite had a mono-layer adsorption capacity of 11.04 mg g− 1 for Co (II) and 21.54 mg g− 1 for Eu (III). According to desorption studies, Co (II) and Eu (III) could be recovered by 0.1 mol L− 1 EDTA with efficiencies 55.46% and 95.044%, respectively. According to thermodynamic studies, the sorption of Co (II) and Eu (III) on the prepared composite was endothermic and spontaneous.
The Challenge of Quantification: An Interdisciplinary Reading
Authors: Di Fiore Monica , Kuc-Czarnecka Marta , Lo Piano Samuele , Puy Arnald , Saltelli Andrea 
Published: December 2022

AbstractThe present work looks at what we call “the multiverse of quantification”, where visible and invisible numbers permeate all aspects and venues of life. We review the contributions of different authors who focus on the roles of quantification in society, with the aim of capturing different and sometimes separate voices. Several scholars, including economists, jurists, philosophers, sociologists, communication and data scientists, express concerns or identify critical areas of our relationship with new technologies of ‘numericization’. While mindful of the important specificities of the different families of quantification, we use our broad and holistic canvas to explore possible spaces for a more systematic investigation of incumbent and novel quantifications, as to increase communication among disciplinary communities, and among these and society, in the pursuit a democratic agency and self-defence.
What does pleasure want?
Authors: Tooming Uku 
Published: December 2022

AbstractSome philosophers and psychologists share an assumption that pleasure is by nature such that when an experience is pleasurable, an agent is motivated to continue having that experience. In this paper, I dispute this assumption. First, I point out how it does not make sense of the wanting-liking distinction in motivational neuroscience. Second, I present as a counterexample what I call’dynamic pleasure’ which does not motivate retaining one’s focus on the object of original experience but motivates an exploration of other options instead. Third, as another counterexample, I bring out pleasures of relief which are bound to pass when one’s discomfort is removed and in which case it is reasonable to assume that there is no motivation to maintain them. Fourth, I appeal to phenomenology of pleasure and argue that many experiences have a temporal shape which is in conflict with the self-maintenance assumption. As an example, I use the pleasure in listening to a song. The conclusion of the paper is that we should reject the self-maintenance assumption and consider seriously pluralism about the motivational structure of pleasure.
Certain averaging operators on Triebel-Lizorkin spaces
Authors: Zhao Jun-yan , Pan Ya-li 
Published: December 2022

AbstractIn this article, we study the boundedness properties of the averaging operatorStγon Triebel-Lizorkin spaces$$\dot F_{p,q}^\alpha \left( {{\mathbb{R}^n}} \right)$$F˙p,qα(ℝn)for variousp,q. As an application, we obtain the norm convergence rate forStγ(f) on Triebel-Lizorkin spaces and the relation between the smoothness imposed on functions and the rate of norm convergence ofStγis given.
1H, 13C, and 15N assignments of the mRNA binding protein hnRNP A18
Authors: Coburn Katherine M. , Roth Braden , Varney Kristen M. , Carrier France , Weber David J. 
Published: December 2022

AbstractHeterogeneous ribonuclear protein A18 (hnRNP A18) is an RNA binding protein (RBP) involved in the hypoxic cellular stress response and regulation of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) expression in melanoma, breast cancer, prostate cancer, and colon cancer solid tumors. hnRNP A18 is comprised of an N-terminal structured RNA recognition motif (RMM) and a C-terminal intrinsically disordered domain (IDD). Upon cellar stressors, such as UV and hypoxia, hnRNP A18 is phosphorylated by casein kinase 2 (CK2) and glycogen synthase kinase 3β (GSK-3β). After phosphorylation, hnRNP A18 translocates from the nucleus to the cytosol where it interacts with pro-survival mRNA transcripts for proteins such as hypoxia inducible factor 1α and CTLA-4. Both the hypoxic cellular response and modulation of immune checkpoints by cancer cells promote chemoradiation resistance and metastasis. In this study, the 1 H, 13 C, and 15 N backbone and sidechain resonances of the 172 amino acid hnRNP A18 were assigned sequence-specifically and provide a framework for future NMR-based drug discovery studies toward targeting hnRNP A18. These data will also enable the investigation of the dynamic structural changes within the IDD of hnRNP A18 upon phosphorylation by CK2 and GSK-3β to provide critical insight into the structure and function of IDDs.
Rapid evaluation model for EOR techniques applicability of gas flooding, foam flooding and surfactant flooding based on modified fractional flow theory
Authors: Chengjun Wang , Jun Ni , Shaojing Jiang , Yiwen Gao , Weibo Wang , Yuan Xue , Lei Zhang , Liming Zheng 
Published: December 2022

AbstractBefore a wide range of enhanced oil recovery (EOR) techniques were implemented for an oilfield, the EOR potential and economic evaluation of the techniques should be evaluated in advance for each reservoir to determine which EOR technique was proper. In an oilfield developed with fluvial delta reservoirs, the complicated distribution of scattered small reservoirs in vertical and horizontal directions brought trouble for evaluation work. A rapid and reliable evaluation model for EOR techniques applicability was necessary to deal with the evaluation simulation for many small reservoirs of an oilfield. Combining fraction theory model with auxiliary equations, which describe the effect of formation heterogeneity and mechanism of different EOR technique on fractional flow rate, an evaluation analysis method for EOR techniques applicability of gas flooding, foam flooding and surfactant flooding was proposed. In the gas flooding model, the minimum miscible pressure of impure gas was introduced, and the relative permeability was modified by the minimum miscible factor. In the foam flooding model, changes in the mobility ratio and chemical adsorption were considered and a reduction factor of mobility ratio was introduced. In the surfactant flooding model, calculation formulas of viscosity and interfacial tension as well as the relative permeability were introduced. Finally, the model was simulated for a low permeability reservoir, and the simulation results were compared with that from Eclipse software. The similar results, little calculation time and feasibility of predicting optimal injection parameter had shown the reliability of the rapid evaluation model.
First documentation of golden jackal (Canis aureus) reproduction in Germany
Authors: Böcker Felix , Weber Hannah , Collet Sebastian 
Published: December 2022

AbstractThe golden jackal (Canis aureus), a mesocarnivore, is currently expanding from eastern towards western Europe. Reproduction of the species could be confirmed in several areas in central Europe in recent years. This study collects the first records of golden jackal reproduction in Germany in 2021 and 2022. A family group of at least five individuals could be confirmed using camera traps and scat surveys with a trained detection dog and subsequent genetic identification in 2021. In 2022, camera traps confirmed a second reproduction in the same area.
Using botanical resources to select wild forage legumes for domestication in temperate grassland agricultural systems
Authors: Micke Brooke , Parsons David 
Published: December 2022

AbstractThe need for better understanding and conservation of wild plant resources with potential for domestication or utilization in crop improvement has been highlighted in recent years. Botanical resources such as herbaria, databases, and floras offer an information-rich platform from which to select species of interest based on desirable traits. To demonstrate the potential of these resources, wild, native forage legumes were screened for inclusion in northern Swedish grassland agricultural systems (leys). The poor persistence of red clover in multi-year leys is a limitation to the current management strategy in the region. Wild, native forage legumes with the potential for longer persistence were considered for inclusion as minor components in leys to contribute to the system in later years of production. Using the Umeå University Herbarium, local floras, and both regional and international biodiversity databases, seven wild forage legume species were selected based on phenology, morphology, and native range. Particular focus was given to the potential for species to provide pollinator resources early in the season, leading to species with early flowering being preferred. Biodiversity databases were also used to locate wild populations of the selected species to facilitate seed collection for future cultivation, as additional study of the agronomic potential of the selected species is necessary. Here, we have shown that the rich biodiversity data stored in botanical institutions can jumpstart the selection of wild species for utilization in the agriculture sector based on various traits of interest.
Green validated chromatographic methods for simultaneous determination of co-formulated oxytetracycline HCl and flunixin meglumine in the presence of their impurities in different matrices
Authors: Nazlawy Hagar N. , Zaazaa Hala E. , Merey Hanan A. , Atty Shimaa A. 
Published: December 2022

AbstractGreen analytical chemistry is an important area of chemical sciences. So, developing competent eco-friendly analytical tools is a big challenge. This study devotes two chromatographic techniques for the simultaneous determination of a binary formulated mixture of oxytetracycline HCl (OXY) and flunixin meglumine (FLU), and their impurities tetracycline (TRC) and 2-chloronicotinic acid (CNA), respectively. Primarily, a TLC densitometric method is proposed and validated using TLC plates sprayed with 5% EDTA of pH 9 as a stationary phase and (acetonitrile/ distilled water/ ethanol 7:2:1, by volume) as a developing system. Well-separated spots are detected at 267 nm where linear relations have been achieved at 0.05–2 μg/band and 0.01–2 μg/band for OXY and FLU, respectively. The second developed and validated method is HPLC which is fulfilled on Hypersil BDS column-C18. A mobile phase of distilled water with 0.1%TFA/ acetonitrile in a ratio of 82: 18, v/v firstly then 70: 30, v/v after 9 min is used in a sequential isocratic elution at 210 nm for FLU and 267 nm for OXY, TRC, and CNA. Sensitive and wide linearity ranges are achieved at 0.05–200 μg/mL for both drugs. The two methods are applied successfully in cattle meat and milk for cited drugs determination. According to ICH guidelines, a validation study has been accomplished for the proposed methods. Statistical comparison has been carried out with official and reported methods. Eventually, the greenness of both procedures is evaluated using Eco-Scale which gives eco-friendly results.
Graphical abstract
Leukocyturia and hematuria enable non-invasive differentiation of Bowman’s capsule rupture severity in PR3-ANCA glomerulonephritis
Authors: Baier Eva , Kluge Ingmar Alexander , Hakroush Samy , Tampe Désirée , Tampe Björn 
Published: December 2022

Abstract
Background
Renal involvement is a common and severe complication of anti-neutrophil cytoplasmic antibody-(ANCA)-associated vasculitis potentially resulting in pauci-immune necrotizing and crescentic ANCA glomerulonephritis (GN) with rapid deterioration of kidney function, progression to end stage kidney disease or, if left untreated, lethal exitus. Analysis of the urinary sediment routinely supports clinical management of ANCA GN, but histopathological implications of aberrancies in the urinary sediment mostly remain elusive. Therefore, we aimed to systematically assess the correlation of aberrancies in the urinary sediment and clinico-pathologic findings.

Methods
A total of 42 kidney biopsies with ANCA GN were retrospectively analyzed in a single-center observational study. Laboratory and histopathological parameters were systematically analyzed and correlated with findings of the urinary sediment.

Results
In the overall ANCA GN cohort, leukocyturia and hematuria were associated among each other, and with markers for non-selective glomerular damage, respectively. Non-invasive measurement of leukocyturia indicated focal (but not extensive) Bowman’s capsule rupture (BCR) specifically in proteinase-3 (PR3)-ANCA GN, whereas hematuria correlated with extensive (but not focal) BCR. Concerning intrarenal immune cell infiltration, leukocyturia was associated with tubulointerstitial plasma cell infiltration in PR3-ANCA GN. Finally, none of these associations were detectable in myeloperoxidase-ANCA GN, implying different modes of kidney damage.

Conclusion
We herein expand our current knowledge by providing evidence that leukocyturia and hematuria enable non-invasive differentiation of BCR severity specifically in PR3-ANCA GN.

Graphical abstract
Historical issues of hydrotherapy in thermal–mineral springs of the Hellenic world
Authors: Voudouris K. , Yapijakis C. , Georgaki Μ.-Ν. , Angelakis A. N. 
Published: December 2022

AbstractMany springs have been recorded in Greece; some of them are characterized as thermo-mineral springs and are associated with their position between Eurasia and Africa, the volcanic activity, and the presence of tectonic faults. The therapeutic use of water (hydrotherapy) has been recorded in ancient Greece since at least 1000 BC. Asclepius was the god of medicine in ancient Greek religion and priests operated his worship centers (Asclepieia) offering medical services in areas with proper climatic conditions. In historical times, Hippocrates from the Aegean island of Kos (460–375 BC) is considered the father of scientific medicine as well as hydrotherapy. During the Hellenistic period, the significance of water in health was widely recognized. In the Roman era, many doctors evolved hydrotherapy treatment and the use of hot baths continued in the early Byzantine period until the sixth century AD. Finally, during the Ottoman period, the kind of respiratory bath, namedHamam, was the dominant form in public baths. Their temperature ranges between 20.5 and 83 °C, and the dominant hydrochemical type is Na-Cl. This review describes the history of hydrotherapy in Greece through the centuries, the physicochemical characteristics of thermal springs, as well as contemporary and future trends and challenges are presented.
A discussion of “unsaturated cell model of effective thermal conductivity of soils”
Authors: Janssen Hans 
Published: December 2022

AbstractIn July 2020, this journal published the article “Unsaturated cell model of effective thermal conductivity of soils”, which presented, validated and analysed a cell-based model for predicting the thermal conductivity of unsaturated soils. This discussion however voices a number of concerns on that article. It is revealed that the original cell model underrates the solid thermal conductivity and that it leads to an overly homogeneous impact of the saturation on the effective soil thermal conductivity. This discussion moreover reasons that the correction of the original cell model, reducing it to the – for this situation outdated – Maxwell-Eucken model voids the analysis’ novelty, hence invalidating its likely impact on the state-of-the-art.
From German East African Rupees to British East African Shillings in Tanganyika: The King and the Kaiser Side by Side
Authors: Pallaver Karin 
Published: December 2022

AbstractPallaver situates German East Africa within the framework of the broader East African region as a way to illuminate the processes of currency standardization in the colonial context. The monetary geography of the region was determined first by the circulation of the rupee and later by Great Britain’s interests to create a common currency for its East African colonies. Pallaver argues that transimperial, international, and regional contexts influenced currency circulation across and within colonies, drawing attention to forms of colonial money and their use by distinct groups, such as African laborers and Indian traders.