bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan buku teks Sejarah lokal Kota Palembang berbasis cronological thinking
Authors: Dhita Aulia Novemy , Asmi Adhitya Rol , Pahlevi Muhammad Reza , Aderoben Andromeda , Rianda Imam Lazio 
Published: January 2023

Penelitian ini berdasarkan permasalahan yaitu bagaimana mengembangkan buku teks sejarah lokal di kelas XI IPS di SMA Negeri di Kota Palembang. Adapun populasi penelitian ini yaitu guru mata pelajaran sejarah kelas XI Social Studies Sekolah Menengah Atas Negeri di Kota Palembang. Sedangkan sampel penelitian yaitu guru mata pelajaran sejarah yang tersebar di Sekolah Menegah Atas Negeri di 14 Kecamatan di Kota Palembang. Metode penelitian yang digunakan yaitu penelitian dan pengembangan model ADDIE. Hasil penelitian menunjukkan bahwa buku teks sejarah lokal Kota Palembang dikembangkan berdasarkan konsep berpikir kronologis pada materi Pemerintahan Kolonial Belanda dan Pendudukan Jepang di Palembang. Diperoleh data bahwa menurut para ahli buku teks sangat layak (88,5%). Begitu pula hasil hasil evaluasi dari para guru mata pelajaran sejarah kelas XI IPS Sekolah Menengah Atas di Kota Palembang, bahwa buku teks tersebut sangat layak untuk diterapkan (85,53%). Dari data-data tersebut dapat disimpulkan bahwa buku teks yang dikembangkan telah memenuhi komponen sebagai buku teks yang valid (berdasarkan pendapat para ahli) dan efektif digunakan oleh para guru mata pelajaran sejarah kelas XI IPS SMA Negeri di Kota Palembang. Hasil penelitian ini direkomendasikan untuk para guru sejarah sebagai pegangan dalam kegiatan pembelajaran sejarah.This research is based on the problem of how to develop local history textbooks for class XI Social Sciences at SMA Negeri in Palembang City. The population of this study was history teachers for class XI Social Studies at State Senior High Schools in Palembang City. Meanwhile, the research sample was history teachers from state senior high schools in 14 sub-districts in Palembang City. The research method used is the ADDIE research and development model. The results showed that local history textbooks for Palembang City were developed based on the concept of chronological thinking on the material of the Dutch Colonial Government and the Japanese Occupation in Palembang. According to experts, the data is that textbooks are very feasible (88.5%). Likewise, the evaluation results from the history subject teachers of class XI Social Sciences at Senior High Schools in Palembang City showed that the textbook was feasible to apply (85.53%). From these data, it can be concluded that the developed reader has fulfilled the components of a good book (based on experts' opinions) and is effectively used by history teachers for class XI Social Sciences at SMA Negeri in Palembang City. The results of this study are recommended for history teachers as a guide in history learning activities.
Analisis kebutuhan pengembangan e-Book mitigasi bencana tanah longsor berbasis Android untuk disabilitas anak di Kabupaten Klaten
Authors: Ningsih Sepfiana Dari , Sayekti Ika Candra , Susilawati Siti Azizah , Pramudita Dias Aziz 
Published: January 2023

Tujuan penelitian yakni mendeskripsikan hasil uji analisis kebutuhan pengembangan e-book mitigasi bencana tanah longsor berbasis android sebagai media pembelajaran ramah difabel sesuai dengan kebutuhannya. Jenis penelitian kualitatif dengan data diperoleh melalui penyebaran angket kepada siswa dan guru. Berdasarkan hasil analisis uji kebutuhan pengembangan e-book diketahui bahwa siswa dan guru SLB se-Kabupaten Klaten membutuhkan adanya pengembangan e-book mitigasi bencana tanah longsor berbasis android sebagai media pembelajaran interaktif dengan data diperoleh 100% responden siswa menjawab perlu dikembangkan dan 99,2% responden guru menjawab perlu dikembangkan. Pengembangan e-book yang dibuat disesuaikan dengan kebutuhan disabilitas anak sekolah dasar sesuai dengan aspek materi, penyajian, kebahasaan serta kegrafikan untuk memudahkan guru dalam menyampaikan materi pembelajaran.The purpose of the research is to describe the results of the needs analysis of the development e-book of an android-based landslide mitigationThis type of research is RnD research with the ADDIE model on a needs test with one stage, namely the analysis of material aspects, presentation, language, and personality. Based on the study of the needs test for developing e-books, it is known that SLB students and teachers in Klaten Regency need the development e-book of an android-based landslide mitigation teacher respondents answered that it needs to be developed. Developing e-books tailored to the needs of elementary school children with disabilities by aspects of the material, presentation, language, and graphics to make it easier for teachers to deliver learning materials. Learning media in the form of e-books can attract students to be more active in studying landslide disaster mitigation. E-book learning media should be applicable in various special schools to attract students' interest in learning and make it easier for teachers to deliver the material.
Voice Assistants’ Responses to Questions About the COVID-19 Vaccine: National Cross-sectional Study
Authors: Sossenheimer Philip , Hong Grace , Devon-Sand Anna , Lin Steven 
Published: January 2023

Background
Artificial intelligence-powered voice assistants (VAs), such as Apple Siri, Google Assistant, and Amazon Alexa, interact with users in natural language and are capable of responding to simple commands, searching the internet, and answering questions. Despite being an increasingly popular way for the public to access health information, VAs could be a source of ambiguous or potentially biased information.

Objective
In response to the ongoing prevalence of vaccine misinformation and disinformation, this study aims to evaluate how smartphone VAs respond to information- and recommendation-seeking inquiries regarding the COVID-19 vaccine.

Methods
A national cross-sectional survey of English-speaking adults who owned a smartphone with a VA installed was conducted online from April 22 to 28, 2021. The primary outcomes were the VAs’ responses to 2 questions: “Should I get the COVID vaccine?” and “Is the COVID vaccine safe?” Directed content analysis was used to assign a negative, neutral, or positive connotation to each response and website title provided by the VAs. Statistical significance was assessed using the t test (parametric) or Mann-Whitney U (nonparametric) test for continuous variables and the chi-square or Fisher exact test for categorical variables.

Results
Of the 466 survey respondents included in the final analysis, 404 (86.7%) used Apple Siri, 53 (11.4%) used Google Assistant, and 9 (1.9%) used Amazon Alexa. In response to the question “Is the COVID vaccine safe?” 419 (89.9%) users received a direct response, of which 408 (97.3%) had a positive connotation encouraging users to get vaccinated. Of the websites presented, only 5.3% (11/207) had a positive connotation and 94.7% (196/207) had a neutral connotation. In response to the question “Should I get the COVID vaccine?” 93.1% (434/466) of users received a list of websites, of which 91.5% (1155/1262) had a neutral connotation. For both COVID-19 vaccine–related questions, there was no association between the connotation of a response and the age, gender, zip code, race or ethnicity, and education level of the respondent.

Conclusions
Our study found that VAs were much more likely to respond directly with positive connotations to the question “Is the COVID vaccine safe?” but not respond directly and provide a list of websites with neutral connotations to the question “Should I get the COVID vaccine?” To our knowledge, this is the first study to evaluate how VAs respond to both information- and recommendation-seeking inquiries regarding the COVID-19 vaccine. These findings add to our growing understanding of both the opportunities and pitfalls of VAs in supporting public health information dissemination.
Performance of a Web-Based Reference Database With Natural Language Searching Capabilities: Usability Evaluation of DynaMed and Micromedex With Watson
Authors: Rui Angela , Garabedian Pamela M , Marceau Marlika , Syrowatka Ania , Volk Lynn A , Edrees Heba H , Seger Diane L , Amato Mary G , Cambre Jacob , Dulgarian Sevan , Newmark Lisa P , Nanji Karen C , Schultz Petra , Jackson Gretchen Purcell , Rozenblum Ronen , Bates David W 
Published: January 2023

Background
Evidence-based point-of-care information (POCI) tools can facilitate patient safety and care by helping clinicians to answer disease state and drug information questions in less time and with less effort. However, these tools may also be visually challenging to navigate or lack the comprehensiveness needed to sufficiently address a medical issue.

Objective
This study aimed to collect clinicians’ feedback and directly observe their use of the combined POCI tool DynaMed and Micromedex with Watson, now known as DynaMedex. EBSCO partnered with IBM Watson Health, now known as Merative, to develop the combined tool as a resource for clinicians. We aimed to identify areas for refinement based on participant feedback and examine participant perceptions to inform further development.

Methods
Participants (N=43) within varying clinical roles and specialties were recruited from Brigham and Women’s Hospital and Massachusetts General Hospital in Boston, Massachusetts, United States, between August 10, 2021, and December 16, 2021, to take part in usability sessions aimed at evaluating the efficiency and effectiveness of, as well as satisfaction with, the DynaMed and Micromedex with Watson tool. Usability testing methods, including think aloud and observations of user behavior, were used to identify challenges regarding the combined tool. Data collection included measurements of time on task; task ease; satisfaction with the answer; posttest feedback on likes, dislikes, and perceived reliability of the tool; and interest in recommending the tool to a colleague.

Results
On a 7-point Likert scale, pharmacists rated ease (mean 5.98, SD 1.38) and satisfaction (mean 6.31, SD 1.34) with the combined POCI tool higher than the physicians, nurse practitioner, and physician’s assistants (ease: mean 5.57, SD 1.64, and satisfaction: mean 5.82, SD 1.60). Pharmacists spent longer (mean 2 minutes, 26 seconds, SD 1 minute, 41 seconds) on average finding an answer to their question than the physicians, nurse practitioner, and physician’s assistants (mean 1 minute, 40 seconds, SD 1 minute, 23 seconds).

Conclusions
Overall, the tool performed well, but this usability evaluation identified multiple opportunities for improvement that would help inexperienced users.
Cross-Tailoring Integrative Alcohol and Risky Sexual Behavior Feedback for College Students: Protocol for a Hybrid Type 1 Effectiveness-Implementation Trial
Authors: Ray Anne E , Mun Eun-Young , Lewis Melissa A , Litt Dana M , Stapleton Jerod L , Tan Lin , Buller David B , Zhou Zhengyang , Bush Heather M , Himelhoch Seth 
Published: January 2023

Background
Underage drinking and related risky sexual behavior (RSB) are major public health concerns on United States college campuses. Although technology-delivered personalized feedback interventions (PFIs) are considered a best practice for individual-level campus alcohol prevention, there is room for improving the effectiveness of this approach with regard to alcohol-related RSB.

Objective
The aims of this study are to (1) evaluate the impact of a brief PFI that integrates content on alcohol use and RSB and is adapted to include a novel cross-tailored dynamic feedback (CDF) component for at-risk first-year college students and (2) identify implementation factors critical to the CDF’s success to facilitate future scale-up in campus settings.

Methods
This study uses a hybrid type 1 effectiveness-implementation design and will be conducted in 3 phases. Phase 1 is a stakeholder-engaged PFI+CDF adaptation guided by focus groups and usability testing. In phase 2, 600 first-year college students who drink and are sexually active will be recruited from 2 sites (n=300 per site) to participate in a 4-group randomized controlled trial to examine the effectiveness of PFI+CDF in reducing alcohol-related RSB. Eligible participants will complete a baseline survey during the first week of the semester and follow-up surveys at 1, 2, 3, 6, and 13 months post baseline. Phase 3 is a qualitative evaluation with stakeholders to better understand relevant implementation factors.

Results
Recruitment and enrollment for phase 1 began in January 2022. Recruitment for phases 2 and 3 is planned for the summer of 2023 and 2024, respectively. Upon collection of data, the effectiveness of PFI+CDF will be examined, and factors critical to implementation will be evaluated.

Conclusions
This hybrid type 1 trial is designed to impact the field by testing an innovative adaptation that extends evidence-based alcohol programs to reduce alcohol-related RSB and provides insights related to implementation to bridge the gap between research and practice at the university level.

Trial Registration
ClinicalTrials.gov NCT05011903; https://clinicaltrials.gov/ct2/show/NCT05011903

International Registered Report Identifier (IRRID)
DERR1-10.2196/43986
Evaluation of Variation in the Performance of GFR Slope as a Surrogate End Point for Kidney Failure in Clinical Trials that Differ by Severity of CKD
Authors: Collier Willem , Inker Lesley A. , Haaland Benjamin , Appel Gerald B. , Badve Sunil V. , Caravaca-Fontán Fernando , Chalmers John , Floege Jürgen , Goicoechea Marian , Imai Enyu , Jafar Tazeen H. , Lewis Julia B. , Li Philip K.T. , Locatelli Francesco , Maes Bart D. , Neuen Brendon L. , Perrone Ronald D. , Remuzzi Giuseppe , Schena Francesco P. , Wanner Christoph , Heerspink Hiddo J.L. , Greene Tom ,   the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)*
Published: January 2023

Background
The GFR slope has been evaluated as a surrogate end point for kidney failure in meta-analyses on a broad collection of randomized controlled trials (RCTs) in CKD. These analyses evaluate how accurately a treatment effect on GFR slope predicts a treatment effect on kidney failure. We sought to determine whether severity of CKD in the patient population modifies the performance of GFR slope.

Methods
We performed Bayesian meta-regression analyses on 66 CKD RCTs to evaluate associations between effects on GFR slope (the chronic slope and the total slope over 3 years, expressed as mean differences in ml/min per 1.73 m2/yr) and those of the clinical end point (doubling of serum creatinine, GFR <15 ml/min per 1.73 m2, or kidney failure, expressed as a log-hazard ratio), where models allow interaction with variables defining disease severity. We evaluated three measures (baseline GFR in 10 ml/min per 1.73 m2, baseline urine albumin-to-creatinine ratio [UACR] per doubling in mg/g, and CKD progression rate defined as the control arm chronic slope, in ml/min per 1.73 m2/yr) and defined strong evidence for modification when 95% posterior credible intervals for interaction terms excluded zero.

Results
There was no evidence for modification by disease severity when evaluating 3-year total slope (95% credible intervals for the interaction slope: baseline GFR [−0.05 to 0.03]; baseline UACR [−0.02 to 0.04]; CKD progression rate [−0.07 to 0.02]). There was strong evidence for modification in evaluations of chronic slope (95% credible intervals: baseline GFR [0.02 to 0.11]; baseline UACR [−0.11 to −0.02]; CKD progression rate [0.01 to 0.15]).

Conclusions
These analyses indicate consistency of the performance of total slope over 3 years, which provides further evidence for its validity as a surrogate end point in RCTs representing varied CKD populations.
A Semantic Framework based on Domain Knowledge for Opinion Mining of Drug Reviews
Authors: Noferesti Samira , Shamsfard Mehrnoush 
Published: January 2023

Opinion mining has been attracting increasing attention in recent years. Existing approaches to opinion mining that have worked on general domains face two major challenges for polarity classification of drug reviews. Firstly, indirect opinions frequently occur in the drug domain, while the existing methods have mainly focused on direct opinions and ignored the indirect ones. Secondly, previous works are not sufficient for polarity classification of ambiguous concepts in the drug domain.
This paper proposed a semantic framework based on domain knowledge for resource construction and exploitation for indirect opinion mining of drug reviews. Accordingly, some methods were introduced, developed, and compared for building and exploiting a combined knowledge base, polarity-tagged corpus, and context-aware resources for the polarity detection of drug reviews. The test results showed that the proposed methods reached a precision of 89.18% and 80.4% in the application of the combined knowledge base and the polarity-tagged corpus for polarity detection of indirect opinions, respectively. Also, a precision of 79.93% was achieved with the use of context-aware resources constructed for the polarity detection of ambiguous concepts. Overall, the results obtained demonstrated the performance of the proposed methods compared to the existing methods.
Incidence of hypoglycemia with glimepiride/metformin fixed-dose combination in patients with type 2 diabetes inadequately controlled on metformin monotherapy in Peru: a prospective, active pharmacovigilance cohort study Short running title: Hypoglycemia with glimepiride plus metformin in Peru
Authors: Pinto-Valdivia Miguel , Loyola Lourdes , Jara Jorge , Damas-Casani Lucy , Guillén Miguel , Medina Cecilia A. 
Published: January 2023

Purpose — To evaluate hypoglycemia incidence rate during treatment
with a fixed-dose combination of glimepiride and metformin in patients
non-responders to metformin monotherapy. Data were collected during
customary specialized practice in Peru where access to effective and
safe, but low-cost medications, is needed. Methods— This was an
observational, prospective, active pharmacovigilance, cohort study with
in-person medical assessments. Medical assessments were conducted every
3-months, with monthly follow-up through phone calls. Data regarding use
and administration of treatment were recorded by patients. Adverse
events (AE) reported by patients and/or ascertained by attending
physicians during the period of 18 months along with treatment-related
events were identified. Cumulative incidence and hypoglycemia incidence
rate were estimated. Poisson and logistic regression models were applied
to study their relationship with risk factors and patterns of use.
Results— 206 patients were enrolled in the study from 10 centers and
were followed for a median duration of 12 months (range, 2-18 months).
Forty treatment-related AEs were reported (cumulative incidence =
19.4%). No severe hypoglycemic events were observed. Most common AE
found was non-severe hypoglycemia (cumulative incidence = 2.4%;
incidence rate = 2.6/100 person/years). Self-administration of a higher
dose than prescribed was associated with a higher probability of an AE
(p=0.03). Conclusions— Administration of a fixed-dose combination of
glimepiride plus metformin was associated with low incidence of
non-severe hypoglycemia, and no incidence of severe hypoglycemia. These
results advocate the use of fixed-dose combination of glimepiride plus
metformin in low- and middle-income countries with limited resources,
even more so in wake of COVID-19 pandemic.
High-performance Biopolymer Cryogels for Transient Sensing Ecology-drones
Authors: Wiesemüller Fabian , Meyer Severin , Hu Yijie , Bachmann Dominik , Parrilli Annapaola , Nyström Gustav , Kovac Mirko 
Published: January 2023

Aerial robots can autonomously collect temporal and spatial
high-resolution environmental data. This data can then be utilized to
develop mathematical ecology models to understand the impact of climate
change on our habitat. In case of the drone’s malfunction the
incorporated materials can threaten vulnerable environments. The recent
introduction of transient robotics has enabled the development of
biodegradable, environmental sensing drones capable of degrading in
their environment. However, manufacturing methods for environmental
sensing transient drones are rarely discussed. In this work, we
highlight a manufacturing framework and material selection process
featuring biopolymer-based, high-strength composite cryogels and printed
carbon-based electronics for transient drones. We found that gelatin and
cellulose based cryogels mechanically outperform other biopolymer
composites while having a homogeneous micro-structure and high
stiffness-to-weight ratio. The selected materials are used to
manufacture a flying-wing air-frame, while the incorporated sensing skin
is capable of measuring the elevons’ deflection angles as well as
ambient temperature. Our results demonstrate how gelatin-cellulose
cryogels can be used to manufacture lightweight transient drones while
printing carbon conductive electronics is a viable method for designing
sustainable, integrated sensors. The proposed methods can be used to
guide the development of lightweight and rapidly degrading robots,
featuring eco-friendly sensing capabilities.
Corresponding author(s)
Email: fabian.wiesemueller@empa.ch,
mirko.kovac@empa.ch
Association Between COVID-19 Mortality and ICU Admission Rates and Prior History of Angiotensin-Converting Enzyme or Angiotensin Receptor Blockers Use Among Hospitalized COVID-19 Patients with Hypertension in Michigan.
Authors: Elhouderi Eiman M. , Elsawaly Eman A. , Al-Sudani Najlaa K. , Mahmood Irum , Sengstock David M. 
Published: January 2023

Abstract:Importance: There are conflicting data
regarding the safety of the use of Angiotensin-converting enzyme
inhibitors or Angiotensin receptor blockers (ACEI/ARBs ) medications in
hypertensive patients who are susceptible to COVID-19.
Objective: Our study assesses the association between COVID-19
severity and mortality and the use of ACEI/ARBs among hospitalized
patients with hypertension. Research design, setting and
participants: This was a retrospective cohort study. Using the EPIC
system of Beaumont Health, we identified 5490 patients with COVID-19 who
were admitted to the eight Beaumont hospitals. After excluding subjects
who have no hypertension and those with missing data, we included 2129
COVID-19 patients who have hypertension. Logistic regression and Cox
proportional hazard models were used to analyze the association history
of ACEI/ARBs use, ICU admission rate and COVID-19 mortality.
Exposure: Using of ACEI/ARBs as documented in the medical
records before admission to the hospitals. Main outcome: 30
days COVID-19 mortality and ICU admission rates .
Results: There were 1281 subjects (60%) with prior ACEI/ARBs
use and 848 subjects ( 40%) with no ACEI/ARBs use. There was no
significant association between ICU admission and use of ACEI/ARBs (odds
ratio was 0.95, 95% CI [0.76, 1.19] and p-value was 0.6). Although
the unadjusted logistic regression model demonstrated a statistically
significant association between history of use of ACEI/ARBs and COVID-19
mortality (odds ratio= 1.31, 95% CI [1.05, 1.66], p-value= 0.02),
the adjusted logistic regression model failed to show this statistically
significant association (odds ratio= 1.20, 95% CI [0.93, 1.54],
p-value= 0.14). Moreover, we were not able to reveal a statistically
significant association between 30 days COVID-19 survival and prior use
of ACEI/ARBs in the adjusted Cox-proportional hazard model (Hazard ratio
(HR) = 1.11, 95% CI [0.91, 1.40], p-value =0.14).
Conclusion: In a large retrospective study, we conclude that
there was no statistically significant association between prior history
of ACEI/ARBs use and COVID-19 ICU admission rates or mortality in
hypertensive patients hospitalized with COVID-19.