bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trial sequential analysis of efficacy and safety of direct oral anticoagulants and vitamin K antagonists against left ventricular thrombus
Authors: Kitano Tetsuji , Nabeshima Yosuke , Kataoka Masaharu , Takeuchi Masaaki 
Published: August 2023

AbstractMeta-analysis may increase the risk of random errors. Trial sequential analysis (TSA) has been developed to adjust for these random errors. We conducted TSA on the efficacy and safety of direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) in left ventricular thrombus (LVT) patients in order to estimate how many additional patients should be required to draw definite conclusions. PubMed, Scopus, and Cochrane Library databases were searched for articles directly comparing DOACs and VKAs for LVT in LV thrombus resolution, stroke, any thromboembolism, major bleeding, any bleeding, and all-cause death. TSA was conducted with a cumulative Z-curve, monitoring boundaries, and required sample size. A simulated trial was run and TSA estimated the sample sizes of trials needed to draw definite conclusions. Of 4749 articles, 25 studies were used for the analysis. TSA revealed the current sample size already demonstrated superiority of DOACs in LV thrombus resolution and stroke, and futility in any thromboembolism and all-cause death. Two other outcomes did not achieve the required sample size. The sample size of new trials needed to demonstrate the superiority of DOACs over VKAs was estimated 400 for any bleeding. Corresponding trials needed to demonstrate no significant differences could be estimated for major bleeding and any bleeding (n = 200 and n = 2000, respectively). Current results show that the sample size required to draw definite conclusions was not reached for two outcomes, and there was a risk of random error. Further randomized controlled trials with sample sizes estimated by TSA will work effectively to obtain valid conclusions.
Measured vs estimated resting energy expenditure in children and adolescents with obesity
Authors: Tamini Sofia , Caroli Diana , Bondesan Adele , Abbruzzese Laura , Sartorio Alessandro 
Published: August 2023

AbstractPediatric obesity requires early targeted interventions consisting mainly of a low-calorie diet prescribed based on resting energy expenditure (REE), often estimated through predictive equations. The aim of this study was to define the prevalence of "hypo-", "normo-" and "hypermetabolic" in a large cohort of children and adolescents with obesity by comparing measured and estimated REE and to evaluate the characteristics related to these metabolic statuses in both males and females. The study population was divided into the three subgroups by comparing REE measured using indirect calorimetry and estimated using the Molnar equation, and subsequently analyzed. The majority of the participants (60.6%) were normometabolic, 25.5% hypermetabolic and 13.9% hypometabolic. No significant differences in age, Tanner stage, systolic blood pressure, or the presence of metabolic syndrome were found. However, the hypermetabolic subgroup was significantly lighter, shorter, with lower hip and waist circumferences, had a greater amount of fat-free mass and lower fat mass, significantly lower diastolic blood pressure, and a significantly higher frequency of non-alcoholic liver steatosis. Pediatric obesity is more associated with normal or increased REE than with a hypometabolic condition, suggesting that estimation of energy expenditure with predictive equations is still inadequate for prescribing the appropriate diet plan.
Comparison between OLIF and MISTLIF in degenerative lumbar stenosis: an age-, sex-, and segment-matched cohort study
Authors: Liu Lantao , Xue Hui , Han Zhiyuan , Jiang Lianghai , Chen Longwei , Wang Dechun 
Published: August 2023

AbstractTo compare outcomes after oblique lateral interbody fusion (OLIF) versus minimally invasive transforaminal lumbar interbody fusion (MISTLIF) with bilateral decompression via unilateral approach for treating mild to moderate symptomatic degenerative lumbar spinal stenosis (DLSS). We retrospectively compared patients who underwent single-level (L4/5) OLIF with an age-, sex-, and segment-matched MISTLIF with bilateral decompression via unilateral approach cohort. Perioperative data were collected for the operative time, intraoperative blood loss, drainage in the first postoperative day, postoperative hospital stay, cost, intraoperative fluoroscopy, and complications. Lumbar radiographs were measured for changes in posterior intervertebral space height (PISH), intervertebral space foramen height (IFH), intervertebral foramen area (IFA), and area of the spinal canal (ASC). Clinical and psychological outcomes included the visual analog scale (VAS), Oswestry Disability Index (ODI), and hospital anxiety and depression scale (HADS). 35 OLIF patients were compared with 35 MISTLIF patients in L4/5 DLSS. The OLIF group had shorter bedtime, postoperative hospital stays, less intraoperative and postoperative blood loss (all P < 0.05), but had more times of intraoperative fluoroscopy, longer operative time, and higher cost (all P < 0.05). The complication rates were equivalent (OLIF vs MISTLIF: 22.86% vs 17.14%). PISH (11.94 ± 1.78 mm vs 9.42 ± 1.94 mm, P < 0.05), IFH (23.87 ± 3.05 mm vs 21.41 ± 2.95 mm, P < 0.05), and IFA (212.14 ± 51.82 mm2 vs 177.07 ± 51.73 mm2, P < 0.05) after surgery were significantly increased in the OLIF group. The ASC was increased significantly after the operation in both groups, but the ASC in the MISTLIF group was increased significantly more than that in the OLIF group (450.04 ± 66.66 mm2 vs 171.41 ± 58.55 mm2, P < 0.05). The lumbar VAS scores at 1 month (1.89 ± 0.87 vs 2.34 ± 0.84, P = 0.028) and 6 months (1.23 ± 0.97 vs 1.80 ± 0.99, P = 0.018) after operation in the OLIF group were significantly lower. There were no significant differences in lower extremity VAS and ODI scores between the two groups. Compared with MISTLIF group, HADS scores on postoperative day 3 (2.91 ± 1.46 vs 4.89 ± 1.78, P < 0.05) and prior to hospital discharge (PTD) (2.54 ± 1.38 vs 3.80 ± 1.78, P = 0.002) in the OLIF group were decreased significantly. OLIF showed more advantages of less surgical invasion, lower incidence of postoperative low back pain, faster postoperative recovery, and less anxiety compared with MISTLIF. Regardless of cost, OLIF seems to be a better option to treat mild to moderate symptomatic DLSS.
Strain enhances the activity of molecular electrocatalysts via carbon nanotube supports
Authors: Su Jianjun , Musgrave Charles B. , Song Yun , Huang Libei , Liu Yong , Li Geng , Xin Yinger , Xiong Pei , Li Molly Meng-Jung , Wu Haoran , Zhu Minghui , Chen Hao Ming , Zhang Jianyu , Shen Hanchen , Tang Ben Zhong , Robert Marc , Goddard William A. , Ye Ruquan 
Published: August 2023

AbstractSupport-induced strain engineering is useful for modulating the properties of two-dimensional materials. However, controlling strain of planar molecules is technically challenging due to their sub-2 nm lateral size. Additionally, the effect of strain on molecular properties remains poorly understood. Here we show that carbon nanotubes (CNTs) are ideal substrates for inducing optimum properties through molecular curvature. In a tandem-flow electrolyser with monodispersed cobalt phthalocyanine (CoPc) on single-walled CNTs (CoPc/SWCNTs) for CO2 reduction, we achieve a methanol partial current density of >90 mA cm−2 with >60% selectivity, surpassing wide multiwalled CNTs at 16.6%. We report vibronic and X-ray spectroscopies to unravel the distinct local geometries and electronic structures induced by the strong molecule–support interactions. Grand canonical density functional theory confirms that curved CoPc/SWCNTs improve *CO binding to enable subsequent reduction, whereas wide multiwalled CNTs favour CO desorption. Our results show the important role of SWCNTs beyond catalyst dispersion and electron conduction.
Irrigation benefits outweigh costs in more US croplands by mid-century
Authors: Partridge Trevor , Winter Jonathan , Kendall Anthony , Basso Bruno , Pei Lisi , Hyndman David 
Published: August 2023

AbstractIrrigation can increase crop yields and could be a key climate adaptation strategy. However, future water availability is uncertain. Here we explore the economic costs and benefits of existing and expanded irrigation of maize and soybean throughout the United States. We examine both middle and end of the 21st-century conditions under future climates that span the range of projections. By mid-century we find an expansion in the area where the benefits of irrigation outweigh groundwater pumping and equipment ownership costs. Increased crop water demands limit the region where maize could be sustainably irrigated, but sustainably irrigated soybean is likely feasible throughout regions of the midwestern and southeastern United States. Shifting incentives for installing and maintaining irrigation equipment could place additional challenges on resource availability. It will be important for decision makers to understand and account for local water demand and availability when developing policies guiding irrigation installation and use.
Built-in tensile strain dependence on the lateral size of monolayer MoS2 synthesized by liquid precursor chemical vapor deposition
Authors: Seravalli L. , Esposito F. , Bosi M. , Aversa L. , Trevisi G. , Verucchi R. , Lazzarini L. , Rossi F. , Fabbri F. 
Published: August 2023

In this work, the authors unveil the depedance of the tensile strain and the size of MoS2 monolayer grown by liquid precursor chemical vapor deposition.
Mixing detection on Bitcoin transactions using statistical patterns
Authors: Shojaeinasab Ardeshir , Motamed Amir Pasha , Bahrak Behnam 
Published: August 2023

AbstractCryptocurrencies, particularly Bitcoin, have garnered attention for their potential in anonymous transactions. However, their anonymity has often been compromised by deanonymization attacks. To counter this, mixing services have been introduced. While they enhance privacy, they obscure fund traceability. This study seeks to demystify transactions linked to these services, shedding light on pathways of concealed and laundered money. We propose a method to identify and classify transactions and addresses of major mixing services in Bitcoin. Unlike previous research focusing on older techniques like CoinJoin, we emphasize modern mixing services. We gathered labelled data by transacting with three prominent mixers (MixTum, Blemder, and CryptoMixer) and identified recurring patterns. Using these patterns, an algorithm was created to pinpoint mixing transactions and distinguish mixer‐related addresses.The algorithm achieved a remarkable recall rate of 100%. Given the lack of clear ground truth and the vast number of unlabelled transactions, ensuring accuracy was a challenge. However, by analyzing a set of non‐mixing transactions with our model, it was confirmed that the high recall rate was not misleading. This work provides a significant advancement in monitoring mixing transactions, presenting a valuable tool against fraud and money laundering in cryptocurrency networks.
Low‐profile multi‐polarization and pattern reconfigurable antenna based on metasurface
Authors: Liang JiaJun , Wu Zhao , Li Long , Zhang Xiuyin , Yang Hua 
Published: August 2023

AbstractIn this letter, a low‐profile metasurface (MS) antenna with multi‐polarization and pattern reconfigurability is presented. The antenna mainly consists of two parts, including a loop antenna fed by balun, and a MS antenna excited by the coupled aperture. When switching the PIN diode and rotating the MS, the multi‐polarization and pattern reconfigurable ability of the antenna is obtained. While the loop antenna is excited, a horizontally linear polarized (HLP) wave and omnidirectional pattern are obtained. Besides, when the MS is operated, due to the differential phase between the orthogonal surface impedance components, the antenna can be switched between vertical linear polarization (VLP), left‐hand circular polarization (LHCP), and right‐hand circular polarization (RHCP). Furthermore, the antenna could achieve a directional pattern. As the simulated and measured results shown, the proposed antenna has an overlapped impedance bandwidth (IMBW) of 24.7% for all polarization modes and a 3‐dB axial ratio (AR) bandwidth of 11.8% for L/RHCP modes. Moreover, the antenna owns a low profile of 0.06 λ (under the operating centre frequency).
Impact of Increased Activated Protein-C Resistance, Decreased
Antithrombin III Activity and Hypocomplementemia on the Gestational Outcomes of
Pregnancies with MTHFR Polymorphisms
Authors: Fadiloglu Erdem , Donmez Hanife Guler , Beksac Kemal , Beksac Mehmet Sinan 
Published: August 2023

Abstract
Objective To evaluate the impact of increased Activated Protein C (APC)
resistance, decreased antithrombin III activity and hypocomplementemia on the
pregnancy outcomes of the patients with methylentetrahydrofolate reductase
(MTHFR) polymorphisms.
Methods This study was composed of 83 pregnancies with MTHFR
polymorphisms. Increased APC resistance, decreased antithrombin III activity and
hypocomplementemia were accepted as risk factors for poor gestational
outcome.
Results Having at least one risk factor resulted in significantly higher
rates of “APGAR score of<7” at the first ten minutes
(p=0.009). Composite adverse outcome rate was also higher in patients
with at least one of the defined risk factors despite lack of statistical
significance (p=0.241). Rate of newborn with an “APGAR score
of<7” at first ten minutes was significantly higher at patients
with hypocomplementemia (p=0.03).
Conclusion Hypocomplementemia is a risk factor for poor gestational
outcome in pregnancies with MTHFR polymorphisms.
Pedicled Flaps for High-Risk Open Vascular Procedures of the Lower Extremity: An Analysis of The National Surgical Quality Improvement Project Database
Authors: Garvey Shannon R. , Valentine Lauren , Weidman Allan A. , Chen Amy , Nanda Asha D. , Lee Daniela , Lin Samuel J. , Lee Bernard T. , Liang Patric , Cauley Ryan P. 
Published: August 2023

Abstract
Background Use of pedicled flaps in vascular procedures is associated with decreased infection and wound breakdown. We evaluated the risk profile and postoperative complications associated with lower extremity open vascular procedures with and without pedicled flaps.
Methods The American College of Surgeons National Surgical Quality Improvement Program database (2010–2020) was queried for Current Procedural Terminology codes representing lower extremity open vascular procedures, including trunk and lower extremity pedicled flaps. Flap patients were compared with a randomized control group without flaps (1:3 cases to controls). Univariate and multivariate analyses were performed.
Results We identified 132,934 adults who underwent lower extremity open vascular procedures. Concurrent pedicled flaps were rare (0.7%), and patients undergoing bypass procedures were more likely to receive a flap than nonbypass patients (69 vs. 64%, p < 0.0001). Flap patients had greater comorbidities. On univariate analysis, flap patients were more likely to experience wound (p = 0.0026), mild systemic (p < 0.0001), severe systemic (p = 0.0452), and all-cause complications (p < 0.0001). After adjusting for factors clinically suspected to be associated with increased risk (gender, body mass index, procedure type, American Society of Anesthesiologists classification, functional status, diabetes, smoking, and albumin < 3.5 mg/dL), wound (p = 0.096) and severe systemic complications (p = 0.0719) were no longer significantly associated with flap patients.
Conclusion Lower extremity vascular procedures are associated with a high risk of complications. Use of pedicled flaps remains uncommon and more often performed in patients with greater comorbid disease. However, after risk adjustment, use of a pedicled flap in high-risk patients may be associated with lower than expected wound and severe systemic complications.
Thermal Challenges in Dynamic Infrared Thermography Used for Perforator Mapping
Authors: Lin Olivia M. , Hunter-Smith David J. , Rozen Warren M. 
Published: August 2023

Abstract
Background The aim of this study is to investigate the different approaches to thermal challenges, both cold and warm, used in dynamic infrared thermography for reconstructive surgery, and explore whether it affects the success of preoperative perforator mapping.
Methods Literature was collected from Ovid Medline, Embase, PubMed, and Cochrane. The references of the full-text articles located from the original search were also appraised. Thirteen articles were extracted for the final qualitative analysis. A systematic review was then conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.
Results Thirteen articles looked at a cold challenge, which included airflow cooling, direct contact cooling, and evaporation-based cooling. Two articles investigated warm challenges. One paper used no challenge, suggesting it unnecessary with a highly sensitive camera. All cold challenges were positively supported by a high level of flap perfusion success and/or a high level of correlation with other forms of investigation.
Conclusion Cold challenges were overall superior to no challenge and warm challenges; however, this conclusion is limited by the small participant size, the possibility of detection bias, and poor methodology detailing. Airflow cooling—specifically, using a desktop fan to blow air for 2 minutes—was noted to likely cause the least discomfort due to a low cooling capacity yet simultaneously maintain effectiveness and allow for a uniform cooling application. Warm challenges showed less conclusive results and were restricted by lack of studies. This topic would benefit from larger scale studies that compare multiple approaches while using standardized equipment to eliminate confounding factors.
Desulfonylative Radical Truce–Smiles Rearrangement Utilizing the Benzimidazoline and Benzimidazolium Redox Couple
Authors: Hasegawa Eietsu , Miyajima Ryo , Okamura Manon , Oomori Kazuki , Iwamoto Hajime , Wakamatsu Kan 
Published: August 2023

AbstractWe have developed protocols for promoting redox reactions utilizing the 2-substituted 1,3-dimethylbenzimidazoline (BIH–R) and benzimidazolium (BI+–R) couples which were applied to the desulfonylative radical Truce–Smiles rearrangement. Expected rearrangement products formed in modest to good yields in these processes, in which added or in situ generated BIH–R serve as electron- and hydrogen-atom-donating reagents or photocatalysts. DFT calculations were carried out to gain the information about the radical intermediates involved in the rearrangement reaction.
Multigram-Scale Synthesis of a gem-Difluoro-Substituted 4,5,6,7-Tetrahydrobenzo[c]thiophen-4-one Heterocycle via Oxidative Chlorination and Radical Smiles Rearrangement
Authors: Jamieson Craig , Henry Martyn C. , Anderson Jack Q. 
Published: August 2023

AbstractWe report an optimized synthetic route towards a functionalized 4,5,6,7-tetrahydrobenzo[c]thiophene heterocycle bearing a gem-difluoromethylene moiety in 4 steps with an overall yield of 43%. The CF2 fragment was incorporated using a building block approach, by coupling an appropriate fluorinated alcohol with a C-3 sulfonyl chloride, synthesized via oxidative chlorination of an exocyclic benzyl thioether. Visible-light-mediated Smiles rearrangement of the resulting fluorosulfonate ester then furnishes the desired fluorinated thiophene scaffold.
Pictorial Essay of Linear Endoscopic Ultrasound Examination of Pancreas Anatomy
Authors: Chavan Radhika , Rajput Sanjay 
Published: August 2023

AbstractEndoscopic ultrasound (EUS) is a widely used imaging modality for both diagnostic and therapeutic purposes. Understanding the anatomy is crucial during a curved linear EUS examination. Compared with other advanced endoscopic techniques, the learning curve for EUS is longer, and the training facilities for EUS are also not widely available. The interest and enthusiasm for EUS among endoscopists is limited by the long learning curve and the scarcity of training programs. Imaging of the pancreas is the most common indication of EUS examination, and many endoscopist often face difficulty in understanding the anatomy and orientation of the pancreas on linear EUS examination. In this article, we will discuss the problems encountered during linear EUS examination and how to overcome each problem with a station-wise pancreas examination.
Acute Limb Ischemia in COVID-19: A Systematic Review
Authors: Indriani Suci , Amshar Mohamed , Nugraha Raka Aldy , Siddiq Taofan , Adiarto Suko 
Published: August 2023

AbstractNumerous studies have reported cases of acute limb ischemia (ALI) in coronavirus disease 2019 (COVID-19), along with a sharp increase of ALI incidence during the COVID-19 pandemic. The objective of this study was to analyze the clinical features, treatment strategies, and outcomes in COVID-19 patients who developed ALI. A systematic search was performed in PubMed, ScienceDirect, and Cochrane to identify relevant articles. Variables of interest included ALI location, ALI and COVID-19 severity, concomitant thrombosis, comorbidities/risk factors, coagulation and inflammatory parameters, therapy, outcome, and cause of death. Data extraction and pooling were conducted by two reviewers. Fifty-six articles with a total of 191 subjects were included in the analysis; 78.5% of the subjects were male; mean age was 64.2 years; 94.2% of cases were ALI de novo; 41.1% of the subjects had ALI stage IIB; 82.7% of ALI occurred in the lower limb. The popliteal artery was the most commonly affected artery (48.2% of subjects); 38.1% of the subjects had severe COVID-19; 11.1% had asymptomatic COVID-19, and 15.9% were post-COVID-19; 50.7% of the subjects had hypertension; 12.0% of the subjects had concomitant thrombosis; 98.1% of the subjects had elevated D-dimer, and 83.3% of the subjects had elevated C-reactive protein; 61.9% of the subjects underwent surgical thromboembolectomy, 21.3% underwent conservative treatment, and 8.1% underwent amputation initially. The overall mortality rate and limb amputation rate were 39.3 and 22.4%, respectively; 67.6% of deaths were due to respiratory failure. Our study supports that COVID-19 is associated with hypercoagulability that may trigger the development of ALI, and that ALI is a possible predictor of poor outcome in COVID-19 patients.
A New Concept in Flap Transfers—Transposition and Rotation of Fasciocutaneous and Myocutaneous Flaps
Authors: Govila Ashok 
Published: August 2023

SummaryA new technique of safely transferring tissues has been tried in three cases. This technique combines the principle of local transposition and rotation flaps in the transfer of fasciocutaneous and myocutaneous flaps, in such a way that the advantages of both the principles are complimented and disadvantages eliminated. The results in the cases treated are being presented.