bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing patient-reported outcome measures among 3 methods of dental implant placement
Authors:   , Engkawong Sunida 
Published: April 2023

The purpose of this study was to compare patient-reported outcome measures including post-operative pain, swelling, patient's expectation and satisfaction among 3 techniques of dental implant placement including a) conventional freehand, b) dynamic, and c) static Computer-Aided Implant Surgery. Ninety patients were randomly assigned to receive dental implant placement with one of the 3 protocols. Participants were asked to fill in a series of self-administered questionnaires assessing 1) pre-operative expectations, 2) post-operative healing events during the first week after surgery, and 3) overall satisfaction with the procedures at two weeks. Eighty-eight patients completed the study, 2 patients in dynamic CAIS group who failed to follow-up were excluded. Comparing among 3 groups, patients’ expectation on the duration of post-operative chewing difficulty was significantly different (p=0.04). Their experiences of the duration of post-operative pain, speaking limitations, and impact on routine activities were significantly different among 3 groups (p=0.01, 0.038, and 0.046, respectively, Kruskal Wallis test). Overall, the duration of post-operative pain and swelling was longer than they expected (p=0.035 and 0.001, respectively, Wilcoxon signed rank test). Nevertheless, no significant difference in magnitude of post-operative pain, swelling, and painkiller consumption was found among the groups. The short-term functional limitations after surgery were deemed acceptable by most participants and 89% were satisfied by the overall procedure. In conclusion, surgical placements of dental implant with conventional freehand, static, and dynamic computer-aided techniques did not result in any difference in the level of post-operative pain and swelling. All techniques appeared to lead to equal levels of satisfaction as expressed by the patients post-operatively. However, the expectation of the duration of chewing difficulty, as well as the experience of pain duration, speaking difficulty and inability to conduct daily routine activities after surgery were significantly different among groups. Patients appeared to significantly underestimate the duration of post-operative pain and swelling.
Iltifāt and Narrative Voice in the Qurʾān: Grammatical Shifts and Nested Dialogue in Sūrahs 19, 20, and 18
Authors: Mutter Jessica 
Published: April 2023

Abstract
This article analyzes the Qurʾān’s use of an Arabic rhetorical device called iltifāt, the shift of person within a text. It addresses the way iltifāt has been interpreted by medieval Muslim exegetes and the implications of its use for the structure and cosmology of the Qurʾān. By analyzing the use of iltifāt in the Qurʾān, the article demonstrates that the qurʾānic narrator exclusively refers to itself in the first-person plural, and that shifts to other persons (e.g., first-person singular) signify shifts into nested dialogues, asides, and/or narratives within narratives. Furthermore, the way this narrator refers to earthly and heavenly beings suggests that this first-person plural narrator holds a distinct place in the Qurʾān’s cosmology, one that is linked to but distinct from God and other inhabitants of the heavens.
Association between statin use and risk of gallstone disease and cholecystectomy: a meta-analysis of 590,086 patients
Authors: Chang Yu , Lin Hong-Min , Chi Kuan-Yu , Lin Wan-Ying , Chou Tsung-Ching 
Published: April 2023

Background
Statins have been reported to reduce the risk of gallstone disease. However, the impacts of different durations of statin use on gallstone disease have not been clarified. The aim of this study is toperform a systematic review with meta-analysis to update and to elucidate the association between statin use and the risk of gallstone disease and cholecystectomy.

Methods
Medline, Embase and Cochrane Library were searched from the inception until August 2022 for relevant articles investigating the difference in the risk of gallstone disease between statin users and non-users (PROSPERO, ID: CRD42020182445). Meta-analyses were conducted using odds ratios (ORs) with corresponding 95% confidence intervals (CIs) to compare the risk of gallstone disease and cholecystectomy between statin user and nonusers.

Results
Eight studies enrolling 590,086 patients were included. Overall, the use of statins was associated with a marginally significant lower risk of gallstone disease than nonusers (OR, 0.91; 95% CI [0.82–1.00]). Further subgroup analysis showed that short-term users, medium-term users, and long-term users were associated with a significantly higher risk (OR, 1.18; 95% CI [1.11–1.25]), comparable risk (OR, 0.93; 95% CI [0.83–1.04]), and significantly lower risk of gallstone diseases (OR, 0.78; 95% CI [0.68–0.90]) respectively, compared to nonusers.

Conclusions
Patients with medium-term or long-term use of statins without discontinuation are at a lower risk of gallstone disease or cholecystectomy.
Effect of the Communities That Care Prevention System on Adolescent Handgun Carrying
Authors: Rowhani-Rahbar Ali , Oesterle Sabrina , Gause Emma L. , Kuklinski Margaret R. , Ellyson Alice M. , Schleimer Julia P. , Dalve Kimberly , Weybright Elizabeth H. , Briney John S. , Hawkins J. David 
Published: April 2023

ImportanceThere is little information on upstream community-based interventions that reduce the prevalence of handgun carrying among adolescents, especially those growing up in rural areas.ObjectiveTo test whether Communities That Care (CTC), a community-based prevention system focusing on risk and protective factors for behavioral problems early in life, reduces handgun carrying prevalence among adolescents growing up in rural areas.Design, Setting, and ParticipantsCommunity-randomized trial of 24 small towns in 7 states assigned randomly to the CTC or control group with outcomes assessed from 2003 to 2011. Participants were youths attending public schools in grade 5 who received consent from their parents to participate (77% of the eligible population) and were repeatedly surveyed through grade 12 with 92% retention. Analyses were conducted from June to November 2022.InterventionsA coalition of community stakeholders received training and technical assistance to install CTC, used local epidemiologic data to identify elevated risk factors and low protective factors for adolescent behavioral problems, and implemented tested preventive interventions for youth, their families, and schools.Main Outcomes and MeasuresHandgun carrying (never vs at least once) operationalized in 2 ways: (1) prevalence of past-year handgun carrying, and (2) cumulative prevalence of handgun carrying from grade 6 through grade 12.ResultsOverall, the 4407 study participants’ mean (SD) age was 12 (.4) years in both CTC (2405 participants) and control (2002 participants) communities in grade 6; about one-half of participants in each group were female (1220 [50.7 %] in the CTC group and 962 [48.1%] in the control group). From grade 6 through grade 12, 15.5% of participants in CTC communities and 20.7% of those in control communities reported carrying a handgun at least once. Youths in CTC communities were significantly less likely to report handgun carrying at a given grade than those in control communities (odds ratio [OR], 0.73; 95% CI, 0.65-0.82). The most pronounced effects were observed in grade 7 (OR, 0.70; 95% CI, 0.42-0.99), grade 8 (OR, 0.58; 95% CI, 0.41-0.74), and grade 9 (OR, 0.65; 95% CI, 0.39-0.91). Cumulatively from grade 6 through grade 12, youths in CTC communities were significantly less likely to report handgun carrying at least once than those in control communities (OR, 0.76; 95% CI, 0.70-0.84). Overall, CTC reduced the prevalence of past-year handgun carrying by 27% at a given grade and by 24% cumulatively through grade 12.Conclusions and RelevanceIn this study, CTC reduced the prevalence of adolescent handgun carrying in participating communities.Trial RegistrationClinicalTrials.gov Identifier: NCT01088542
Liquid‐Superspreading‐Boosted High‐Performance Jet‐Flow Boiling for Enhancement of Phase‐Change Cooling
Authors: Xu Zhe , Zhang Peng , Yu Chuanghui , Miao Weining , Chang Qiankun , Qiu Ming , Li Yulong , Tian Ye , Jiang Lei 
Published: April 2023

AbstractEnhanced boiling heat transfer via surface engineering is a topic of general interest for its great demand in industrial fields. However, as a dynamic interfacial phenomenon, a deep understanding of its process and mechanism, including liquid re‐wetting and vapor departure, is still challenging. Herein, a micro‐/nanostructured Cu surface containing a periodic microgroove/pyramid array with rich nanowrinkles is designed, where superspreading (<134.1 ms) of organic cooling agents highly boosts the liquid re‐wetting process, causing a discontinuous solid–liquid–vapor three‐phase contact line and ultralow under‐liquid bubble adhesion force (≈1.3 µN). Therefore, a characteristic, ultrafast jet‐flow boiling (bubbles rapidly ejected in multiple strips) is obtained on this surface, giving a priority to nucleation (superheat ≈ 1.5 °C) and simultaneously enhancing the critical heat flux and heat‐transfer coefficient by up to 80% and 608%, respectively, compared with a flat surface. In situ observation and analysis of the nucleation, growth, and departure of micro‐sized jet‐flow bubbles reflects that microgrooves/pyramids with nanowrinkles promote the latent heat exchange process by superspreading‐induced ultrafast liquid re‐wetting and constant vapor film coalescing. Based on the designed structures, high‐performance phase‐change cooling for central processing unit heat management in supercomputer centers is accomplished with an ultralow power usage effectiveness (PUE < 1.04).
Universal Renaissance Strategy of Metal Fluoride in Secondary Ion Batteries Enabled by Liquid Metal Gallium
Authors: Yang Jinghao , Zhou Wei , Hu Jiaming , Jiang Ruohan , Sun Guangai , Zhao Jie , Wang Fei , Fang Fang , Song Yun , Sun Dalin 
Published: April 2023

AbstractAll‐solid‐state alkali ion batteries represent a future trend in battery technology, as well as provide an opportunity for low‐cost metal fluoride electrode materials, if certain intrinsic problems can be resolved. In this work, a liquid metal activation strategy is proposed in which liquid Ga elements are generated in situ and doped into the LiF crystal structure by introducing a small amount of GaF3. Benefiting from these two Ga states of existence, in which the liquid metal Ga can continuously maintain conformable ion/electron‐transport networks, while doped Ga in the LiF crystal structure catalyzes LiF splitting, the lithium‐ion storage capacity of MnF2 significantly increases by 87%. A similar effect can be obtained in FeF3, where the sodium‐ion storage capacity is enhanced by 33%. This universal strategy with few restrictions can be used to realize a complete renaissance of metal fluorides, as well as offer an opportunity for the new application of liquid metals in the field of energy storage.
The Indenyl Effect: Accelerated C−H Amidation of Arenes via Ind*RhIII Nitrene Transfer Catalysis**
Authors: Atkin Liselle , Priebbenow Daniel L. 
Published: April 2023

AbstractInvestigations into C−H amidation reactions catalysed by cationic half‐sandwich d6 metal complexes revealed that the indenyl‐derived catalyst [Ind*RhCl2]2 significantly accelerated the directed ortho C−H amidation of benzoyl silanes using 1,4,2‐dioxazol‐5‐ones. Ring slippage involving a haptotropic η5 to η3 rearrangement of the indenyl complex proposedly enables ligand substitution at the metal centre to proceed via associative, rather than dissociative pathways, leading to significant rate and yield enhancements. Intriguingly, this phenomenon appears specific for C−H amidation reactions involving weakly coordinating carbonyl‐based directing groups with no acceleration observed for the corresponding reactions involving strongly coordinating nitrogen‐based directing groups.
Delayed Doublet Emission in a Cerium(III) Complex
Authors: Fang Peiyu , Liu Jiawen , Liu Huanyu , Yu Gang , Fu Pengxiang , Wang Bingwu , Qu Jianglan , Huang Yanyi , Bian Zuqiang , Liu Zhiwei 
Published: April 2023

AbstractDoublet emission from open‐shell molecules has demonstrated its research and application value in recent years. However, understandings of the photoluminescence mechanism of open‐shell molecules are far less than that of closed‐shell molecules, leading to challenges in molecular design of efficient doublet emission systems. Here we report a cerium(III) 4‐(9H‐carbozol‐9‐yl)phenyl‐tris(pyrazolyl)borate complex Ce(CzPhTp)3 with a new luminescence mechanism of delayed doublet emission, which also represents the first example with metal‐centered delayed photoluminescence. The energy gap between the doublet and triplet excited states of Ce(CzPhTp)3 is reduced by the management of the inner and outer coordination spheres, thereby promoting efficient energy transfer between the two excited states and activating the delayed emission. The photoluminescence mechanism discovered may provide a new way for the design of efficient doublet emission and bring insights into rational molecular design and energy level regulation in open‐shell molecules.
Insight into Bioactivity of In‐situ Trapped Enzyme‐Covalent‐Organic Frameworks
Authors: Liang Jieying , Ruan Juanfang , Njegic Bosiljka , Rawal Aditya , Scott Jason , Xu Jiangtao , Boyer Cyrille , Liang Kang 
Published: April 2023

AbstractSelecting a suitable support material for enzyme immobilization with excellent biocatalytic activity and stability is a critical aspect in the development of functional biosystems. The highly stable and metal‐free properties of covalent‐organic frameworks (COFs) make them ideal supports for enzyme immobilization. Herein, we constructed three kinds of COFs via a biofriendly and one‐pot synthetic strategy at room temperature in aqueous solution. Among the three developed COFs (COF‐LZU1, RT‐COF‐1 and ACOF‐1), the horseradish peroxidase (HRP)‐incorporated COF‐LZU1 is found to retain the highest activity. Structural analysis reveals that a weakest interaction between the hydrated enzyme and COF‐LZU1, an easiest accessibility by the COF‐LZU1 to the substrate, as well as an optimal conformation of enzyme together promote the bioactivity of HRP‐COF‐LZU1. Furthermore, the COF‐LZU1 is revealed to be a versatile nanoplatform for encapsulating multiple enzymes. The COF‐LZU1 also offers superior protection for the immobilized enzymes under harsh conditions and during recycling. The comprehensive understanding of interfacial interactions of COF host and enzyme guest, the substrate diffusion, as well as the enzyme conformation alteration within COF matrices represents an opportunity to design the ideal biocatalysts and opens a broad range of applications of these nanosystems.
Controlled Continuous Evolution of Enzymatic Activity Screened at Ultrahigh Throughput Using Drop‐Based Microfluidics
Authors: Rosenthal R. G. , Diana Zhang X. , Đurđić K. Ilić , Collins J. J. , Weitz D. A. 
Published: April 2023

AbstractEnzymes are highly specific catalysts delivering improved drugs and greener industrial processes. Naturally occurring enzymes must typically be optimized which is often accomplished through directed evolution; however, this is still a labor‐ and capital‐intensive process, due in part to multiple molecular biology steps including DNA extraction, in vitro library generation, transformation, and limited screening throughput. We present an effective and broadly applicable continuous evolution platform that enables controlled exploration of fitness landscape to evolve enzymes at ultrahigh throughput based on direct measurement of enzymatic activity. This drop‐based microfluidics platform cycles cells between growth and mutagenesis followed by screening with minimal human intervention, relying on the nCas9 chimera with mutagenesis polymerase to produce in vivo gene diversification using sgRNAs tiled along the gene. We evolve alditol oxidase to change its substrate specificity towards glycerol, turning a waste product into a valuable feedstock. We identify a variant with a 10.5‐fold catalytic efficiency.
Activation of NR1H3 attenuates the severity of septic myocardial injury by inhibiting NLRP3 inflammasome
Authors: Deng Chao , Liu Qiong , Zhao Huadong , Qian Lu , Lei Wangrui , Yang Wenwen , Liang Zhenxing , Tian Ye , Zhang Shaofei , Wang Changyu , Chen Ying , Yang Yang 
Published: April 2023

AbstractMost sepsis deaths are due to the development of multiple organ failure, in which heart failure is a recognized manifestation of sepsis. To date, the role of liver X receptors α (NR1H3) in sepsis is still uncertain. Here, we hypothesized that NR1H3 mediates multiple essential sepsis‐related signalings to attenuate septic heart failure. Adult male C57BL/6 or Balbc mice and HL‐1 myocardial cell line were performed for in vivo and in vitro experiments, respectively. NR1H3 knockout mice or NR1H3 agonist T0901317 was applied to evaluate the impact of NR1H3 on septic heart failure. We found decreased myocardial expression levels of NR1H3‐related molecules while increased NLRP3 level in septic mice. NR1H3 knockout worsensed cardiac dysfunction and injury in mice subjected to cecal ligation and puncture (CLP), in association with exacerbated NLRP3‐mediated inflammation, oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis‐related markers. The administration of T0901317 reduced systemic infection and improve cardiac dysfunction in septic mice. Moreover, Co‐IP assays, luciferase reporter assays, and chromatin immunoprecipitation analysis, confirmed that NR1H3 directly repressed NLRP3 activity. Finally, RNA‐seq detection further clarified an overview of the roles of NR1H3 in sepsis. In general, our findings indicate that NR1H3 had a significant protective effect against sepsis and sepsis‐induced heart failure.
Neoadjuvant therapy with camrelizumab plus gemcitabine and cisplatin for patients with muscle‐invasive bladder cancer: A multi‐center, single‐arm, phase 2 study
Authors: Han Sujun , Ji Zhigang , Jiang Junhui , Fan Xinrong , Ma Qi , Hu Linjun , Zhang Wen , Ping Hao , Wang Jiansong , Xu Wanhai , Shi Benkang , Wang Wei , Wang Haifeng , Wang Honglei , Chen Shouzhen , Hu Hailong , Guo Jianming , Zhang Shen , Jiang Shuai , Zhou Quan , Xing Nianzeng 
Published: April 2023

AbstractBackgroundNeoadjuvant chemotherapy followed by radical cystectomy (RC) is the standard of care for patients with muscle‐invasive bladder cancer (MIBC). However, treatment outcomes are suboptimal. Camrelizumab, a PD‐1 blockade, has shown benefits in several tumors. This study aimed to investigate the efficacy and safety of neoadjuvant camrelizumab in combination with gemcitabine plus cisplatin (GC) followed by RC for MIBC patients.MethodsThis was a multi‐center, single‐arm study that enrolled MIBC patients with a clinical stage of T2‐4aN0‐1M0, and scheduled for RC. Patients received three 21‐day cycles of camrelizumab 200 mg on day 1, gemcitabine 1000 mg/m2 on day 1 and 8, and cisplatin 70 mg/m2 on day 2, followed by RC. The primary endpoint was pathologic complete response (pCR, pT0N0).ResultsFrom May 2020 to July 2021, 43 patients were enrolled and received study medications at nine centers in China. Three of them were deemed ineligible and excluded from efficacy analysis but included in safety analysis. In total 10 patients were unevaluable as they declined RC (two due to adverse events [AEs] and eight due to patient's willingness). Among 30 evaluable patients, 13 patients (43.3%) achieved pCR, and 16 patients (53.3%) achieved pathologic downstaging. No AEs leading to death were observed. The most common AEs were anemia (69.8%), decreased white blood cell count (65.1%), and nausea (65.1%). Immune‐related AEs were all grade 1 or 2. Pathologic response was not correlated with PD‐L1 expression status or tumor mutation burden. Individual genes as a biomarker for pathologic response were not identified.ConclusionsNeoadjuvant treatment with camrelizumab and GC regimen demonstrated preliminary anti‐tumor activity for MIBC patients with manageable safety profiles. The study met its primary endpoint, and the following randomized trial is ongoing.
Pannexin 3 activates P2X7 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis
Authors: Xiao Jialing , Li Yali , Zhang Jie , Xu Guochao , Zhang Jianxing 
Published: April 2023

AbstractPannexin 3 (Panx3) is involved in regulation of the proliferation and differentiation in chondrocytes and pathological process in osteoarthritis, but its role and potential mechanism in temporomandibular joint osteoarthritis (TMJOA) are still unclear, which are thus explored in our research. We established TMJOA animal model and cell model. In vivo, after silencing Panx3, the pathological changes of condylar cartilage tissue were analyzed by tissue staining, while expressions of Panx3, P2X7 receptor (P2X7R), NLRP3, and cartilage matrix‐related genes were measured by immunohistochemistry (for animal model) or immunofluorescence (for cell model), quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR) or western blot. In addition, the activation of inflammation‐related pathways was detected by qRT‐PCR or western blot, and intracellular adenosine triphosphate (ATP) level was tested by ATP kit. The role of Panx3 in TMJOA was proved by loss‐ and gain‐of‐function assays. P2X7R antagonist was employed to verify the relationship between Panx3 and P2X7R. Panx3 silencing alleviated the damage of condyle cartilage tissue in TMJOA rats, and reduced expressions of Panx3, P2X7R, cartilage matrix degradation related‐enzymes, and NLRP3 in condyle cartilage tissue. In TMJOA cell model, the expressions of Panx3, P2X7R, cartilage matrix degradation related‐enzymes were increased, and inflammation‐related pathways were activated, meanwhile interleukin‐1β treatment promoted the release of intracellular ATP to the extracellular space. The above‐mentioned response was enhanced by Panx3 overexpression and reversed by Panx3 silencing. P2X7R antagonist reversed the regulation of Panx3 overexpression. In conclusion, Panx3 may activate P2X7R by releasing ATP to mediate inflammation and cartilage matrix degradation in TMJOA.
Electrochemical CO2 Reduction with a Heterogenized Iridium−Pincer Catalyst in Water
Authors: De Tovar Jonathan , Ghosh Ashta C. , Di Santo Tom , Curtil Mathieu , Aldakov Dmitry , Koepf Matthieu , Gennari Marcello 
Published: April 2023

AbstractImmobilization of well‐defined homogenous (electro)catalysts onto conductive supports offers an attractive strategy for designing advanced functional materials for energy conversion. In this context, this study reports (i) the introduction of a pyrene anchoring group on a PNP−pincer IrI complex previously described as a selective catalyst for the electrodriven CO2 reduction (CO2RR) into CO in DMF/water mixtures, (ii) the comparison of its CO2RR activity in DMF/water mixtures with the ones of two pyrene‐free reference complexes, and (iii) its activity in pure water after immobilization onto carbon nanotubes (CNTs). Surprisingly, in homogeneous conditions we find HCOO−, instead of CO, as the main CO2 reduction product for the three catalysts. After immobilization on CNTs, even if non‐negligible competitive proton reduction reaction is observed in fully aqueous media, the complex is still able to drive CO2RR and produce HCOO− with a significantly lower overpotential with respect to solution studies.