bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human TrkAR649W mutation impairs nociception, sweating and cognitive abilities: a mouse model of HSAN IV
Authors: Pacifico Paola , Testa Giovanna , Amodeo Rosy , Mainardi Marco , Tiberi Alexia , Convertino Domenica , Arevalo Juan Carlos , Marchetti Laura , Costa Mario , Cattaneo Antonino , Capsoni Simona 
Published: December 2022

AbstractA functional nerve growth factor NGF–Tropomyosin Receptor kinase A (TrkA) system is an essential requisite for the generation and maintenance of long-lasting thermal and mechanical hyperalgesia in adult mammals. Indeed, mutations in the gene encoding for TrkA are responsible for a rare condition, named Hereditary Sensory and Autonomic Neuropathy type IV (HSAN IV), characterized by the loss of response to noxious stimuli, anhidrosis and cognitive impairment. However, to date, there is no available mouse model to properly understand how the NGF–TrkA system can lead to pathological phenotypes that are distinctive of HSAN IV. Here, we report the generation of a knock-in mouse line carrying the HSAN IV TrkAR649W mutation. First, by in vitro biochemical and biophysical analyses, we show that the pathological R649W mutation leads to kinase-inactive TrkA also affecting its membrane dynamics and trafficking. In agreement with the HSAN IV human phenotype, TrkAR649W/m mice display a lower response to thermal and chemical noxious stimuli, correlating with reduced skin innervation, in addition to decreased sweating in comparison to TrkAh/m controls. Moreover, the R649W mutation decreases anxiety-like behavior and compromises cognitive abilities, by impairing spatial-working and social memory. Our results further uncover unexplored roles of TrkA in thermoregulation and sociability. In addition to accurately recapitulating the clinical manifestations of HSAN IV patients, our findings contribute to clarifying the involvement of the NGF–TrkA system in pain sensation.
Structural change, productive development, and capital flows: does financial “bonanza” cause premature deindustrialization?
Authors: Botta Alberto , Yajima Giuliano Toshiro , Porcile Gabriel 
Published: December 2022

AbstractRecent contributions to the literature on industrialization and development have confirmed that manufacturing continues to play a key role as a driver of economic development. As a corollary, these contributions highlight the importance of premature industrialization as a barrier to economic development and as one of the main sources of the middle-income trap. In this paper, we analyze the factors that may have hindered industrial development in the past four decades. In particular, we focus on the role of (non-Foreign Direct Investment) net capital inflows as a potential source of premature deindustrialization. We consider a sample of 36 developed and developing countries from 1980 to 2017, with major emphasis on the case of emerging and developing economies (EDEs) in the context of increasing financial integration. We show that periods of abundant capital inflows may have caused a significant contraction of manufacturing share to employment and GDP, as well as the decrease of the economic complexity index. We also show that the phenomena of “perverse” structural changes are significantly more relevant in EDE countries than in advanced ones and that they may similarly occur across EDE countries, regardless of structural differences in the way manufacturing contributed to their development. Based on such evidence, we conclude with some policy suggestions highlighting capital controls and external macroprudential measures taming international capital mobility as useful policy tools for promoting long-run productive development on top of strengthening (short-term) financial and macroeconomic stability.
A degenerating convection–diffusion system modelling froth flotation with drainage
Authors: Bürger Raimund , Diehl Stefan , Martí M Carmen , Vásquez Yolanda 
Published: December 2022

Abstract
Froth flotation is a common unit operation used in mineral processing. It serves to separate valuable mineral particles from worthless gangue particles in finely ground ores. The valuable mineral particles are hydrophobic and attach to bubbles of air injected into the pulp. This creates bubble-particle aggregates that rise to the top of the flotation column where they accumulate to a froth or foam layer that is removed through a launder for further processing. At the same time, the hydrophilic gangue particles settle and are removed continuously. The drainage of liquid due to capillarity is essential for the formation of a stable froth layer. This effect is included into a previously formulated hyperbolic system of partial differential equations that models the volume fractions of floating aggregates and settling hydrophilic solids [R. Bürger, S. Diehl and M.C. Martí, IMA. J. Appl. Math. 84 (2019) 930–973]. The construction of desired steady-state solutions with a froth layer is detailed and feasibility conditions on the feed volume fractions and the volumetric flows of feed, underflow and wash water are visualized in so-called operating charts. A monotone numerical scheme is derived and employed to simulate the dynamic behaviour of a flotation column. It is also proven that, under a suitable Courant-Friedrichs-Lewy condition, the approximate volume fractions are bounded between zero and one when the initial data are.
Decentering Hegemony and “Open” Orders: Fifteenth-Century Melaka in a World of Orders
Authors: Pardesi Manjeet S 
Published: December 2022

AbstractI explain the differences between centered and decentered systems (world orders) by adopting a relational approach to international relations. I argue that centric systems have three characteristics: most meaningful social relations are oriented toward one center; this center establishes the practices governing social relations; and the center recognizes no peers. Conversely, if these attributes are not the chief hallmarks of a social system, then it is decentered. More specifically, I analyze fifteenth-century Melaka to show that simultaneous participation in multiple world orders is a distinct response to hegemony that decenters it. Melaka recognized Ming hegemony but decentered it by also participating in the Persian cosmopolis, and by emerging as a (mini-)center in maritime Southeast Asia. My analysis has two main implications. First, I make the case for “open” orders—multiple, (partially) overlapping orders as viable and long-lasting systems—in contrast to the realist and liberal logics of orders of exclusion/inclusion. Second, this has implications for contemporary Southeast Asian “choices” in the context of the US–China rivalry as these states are likely to “openly” participate in the American and Chinese world orders simultaneously instead of choosing between them. My relational perspective rooted in global history argues against treating historical East Asia as “closed” for such a view is prone to both Sinocentrism and Eurocentrism. Instead, I emphasize the pivotal role played by Melaka—that pursued the strategy of attraction to manage its unequal world—and make the case for “open” orders without flattening power hierarchies or cultural differences.
How cosmic rays mediate the evolution of the interstellar medium
Authors: Simpson Christine M , Pakmor Rüdiger , Pfrommer Christoph , Glover Simon C O , Smith Rowan 
Published: December 2022

ABSTRACT
We explore the impact of diffusive cosmic rays (CRs) on the evolution of the interstellar medium (ISM) under varying assumptions of supernova explosion environment. In practice, we systematically vary the relative fractions of supernovae (SN) occurring in star-forming high-density gas and those occurring in random locations decoupled from star-forming gas to account for SN from run-away stars or explosions in regions that have been cleared by prior SN, stellar winds, or radiation. We find that in the simple system of a periodic stratified gas layer the ISM structure will evolve to one of two solutions: a ‘peak driving’ state where warm gas is volume filling or a ‘thermal runaway’ state where hot gas is volume filling. CR pressure and transport are important factors that strongly influence the solution state the ISM reaches and have the ability to flip the ISM between solutions. Observable signatures such as gamma-ray emission and H i gas are explored. We find that gamma-ray luminosity from pion decay is largely consistent with observations for a range of model parameters. The thickness of the H i gas layer may be too compact, however, this may be due to a large cold neutral fraction of mid-plane gas. The volume fraction of hot gas evolves to stable states in both solutions, but neither settles to a Milky Way-like configuration, suggesting that additional physics omitted here (e.g. a cosmological circumgalactic medium, radiation transport, or spectrally resolved and spatially varying CR transport) may be required.
SAMI-H i: the connection between global asymmetry in the ionized and neutral atomic hydrogen gas in galaxies
Authors: Watts Adam B , Cortese Luca , Catinella Barbara , Power Chris , Fraser-McKelvie Amelia , Bryant Julia J , Croom Scott M , van de Sande Jesse , Bland-Hawthorn Joss , Groves Brent 
Published: December 2022

ABSTRACT
Observations of the neutral atomic hydrogen (${\rm H\, {\small I}}$) gas in galaxies are predominantly spatially unresolved, in the form of a global ${\rm H\, {\small I}}$ spectral line. There has been substantial work on quantifying asymmetry in global ${\rm H\, {\small I}}$ spectra (‘global ${\rm H\, {\small I}}$ asymmetry’), but due to being spatially unresolved, it remains unknown what physical regions of galaxies the asymmetry traces, and whether the other gas phases are affected. Using optical integral field spectrograph (IFS) observations from the Sydney AAO Multi-object IFS (SAMI) survey for which global ${\rm H\, {\small I}}$ spectra are also available (SAMI-${\rm H\, {\small I}}$), we study the connection between asymmetry in galaxies’ ionized and neutral gas reservoirs to test if and how they can help us better understand the origin of global ${\rm H\, {\small I}}$ asymmetry. We reconstruct the global Hα spectral line from the IFS observations and find that while some global Hα asymmetries can arise from disturbed ionized gas kinematics, the majority of asymmetric cases are driven by the distribution of Hα-emitting gas. When compared to the ${\rm H\, {\small I}}$, we find no evidence for a relationship between the global Hα and ${\rm H\, {\small I}}$ asymmetry. Further, a visual inspection reveals that cases where galaxies have qualitatively similar Hα and ${\rm H\, {\small I}}$ spectral profiles can be spurious, with the similarity originating from an irregular 2D Hα flux distribution. Our results highlight that comparisons between global Hα and ${\rm H\, {\small I}}$ asymmetry are not straightforward, and that many global ${\rm H\, {\small I}}$ asymmetries trace disturbances that do not significantly impact the central regions of galaxies.
A polarimetric study of 9 PG quasars with the VLA
Authors: Baghel Janhavi , Kharb P , S. Silpa , Ho Luis C , Harrison C M 
Published: December 2022

Abstract
We present polarization images of 9 radio-loud (RL) quasars from the VLA B-array at 6 GHz. These quasars belong to the Palomar-Green (PG) ‘blazar’ sample comprising 16 RL quasars and 8 BL Lac objects. Extensive polarization is detected in the cores, jets and lobes of all the quasars, with cores primarily displaying magnetic (B-) fields transverse to, and jets displaying fields aligned with the jet direction. Hotspots display either transverse B-fields signifying B-field compression at terminal shocks or more complex structures. The fractional polarization in the cores ranges from 1-10 per cent and jets/lobes from 10-40 per cent. Several of the quasars show distorted or hybrid FRI/FRII radio morphologies with indications of restarted AGN activity. We attribute this to the optical/UV selection criteria of the PG sample that remains unbiased at radio frequencies. The in-band spectral indices of the radio cores are relatively flat while they are steep in the hotspots. This is consistent with the polarization structures where the hotspots appear to be locations of jet bends or bow-shocks. We present global properties for the entire PG ‘blazar’ sample. We find that jet powers correlate with accretion rates for the quasars; higher accretion rates result in more powerful radio jets. A correlation between the radio core fractional polarization and the 150 MHz total radio luminosity for the 9 quasars studied here may imply that more organized B-fields at the jet bases lead to higher core fractional polarization and to more radio powerful radio jets.
First overtone Cepheids of the OGLE Magellanic Cloud Collection – beyond radial modes
Authors: Smolec R , Ziółkowska O , Ochalik M , Śniegowska M 
Published: December 2022

ABSTRACT
We have analysed Optical Gravitational Lensing Experiment photometry for first overtone classical Cepheids in the Large and Small Magellanic Clouds in search for additional periodicities beyond radial modes. We have used standard consecutive pre-whitening technique in some cases followed by time-dependent pre-whitening. We report new candidates for double-mode radial pulsations. However, majority of signals we have detected cannot be interpreted in terms of radial modes. We report 516 double-periodic stars with period ratios, Px/P1O, in the range 0.60–0.65. We study the properties of this class and implications for model explaining these periodicities. We also report 28 stars in which additional variability is of longer period, below radial fundamental mode, with median period ratio, P1O/Px, of 0.684. This class is an analogue of a class known in RR Lyrae stars. Hundreds of other signals were detected that cannot be attributed to radial modes or the above-mentioned classes. Statistical properties of these signals are analysed. We suggest that majority of these signals correspond to non-radial modes. In particular, a significant fraction can be attributed to non-radial modes of moderate degrees, tightly connected to a class with period ratios in between 0.60 and 0.65. In tens of stars, close to radial mode frequency, relatively large-amplitude and coherent signals are observed, which may represent yet another class. In 27 stars periodic modulation of pulsation was detected. Differences in additional frequency content between the two Clouds are discussed.
Probing quasar lifetimes with proximate 21-centimetre absorption in the diffuse intergalactic medium at redshifts z ≥ 6
Authors: Šoltinský Tomáš , Bolton James S , Molaro Margherita , Hatch Nina , Haehnelt Martin G , Keating Laura C , Kulkarni Girish , Puchwein Ewald 
Published: December 2022

ABSTRACT
Enhanced ionizing radiation in close proximity to redshift z ≳ 6 quasars creates short windows of intergalactic Ly α transmission blueward of the quasar Ly α emission lines. The majority of these Ly α near-zones are consistent with quasars that have optically/UV bright lifetimes of $t_{\rm Q}\sim 10^{5}\!-\!10^{7}\rm \, yr$. However, lifetimes as short as $t_{\rm Q}\lesssim 10^{4}\rm \, yr$ appear to be required by the smallest Ly α near-zones. These short lifetimes present an apparent challenge for the growth of $\sim 10^{9}\rm \, M_{\odot }$ black holes at z ≳ 6. Accretion over longer time-scales is only possible if black holes grow primarily in an obscured phase, or if the quasars are variable on time-scales comparable to the equilibriation time for ionized hydrogen. Distinguishing between very young quasars and older quasars that have experienced episodic accretion with Ly α absorption alone is challenging, however. We therefore predict the signature of proximate 21-cm absorption around z ≳ 6 radio-loud quasars. For modest pre-heating of intergalactic hydrogen by the X-ray background, where the spin temperature $T_{\rm S} \lesssim 10^{2}\rm \, K$ prior to any quasar heating, we find proximate 21-cm absorption should be observable in the spectra of radio-loud quasars. The extent of the proximate 21-cm absorption is sensitive to the integrated lifetime of the quasar. Evidence for proximate 21-cm absorption from the diffuse intergalactic medium within $2\!-\!3\rm \, pMpc$ of a (radio-loud) quasar would be consistent with a short quasar lifetime, $t_{\rm Q}\lesssim 10^{5}\rm \, yr$, and would provide a complementary constraint on models for high-redshift black hole growth.
Concerning colour: The effect of environment on type Ia supernova colour in the dark energy survey
Authors: Kelsey L , Sullivan M , Wiseman P , Armstrong P , Chen R , Brout D , Davis T M , Dixon M , Frohmaier C , Galbany L , Graur O , Kessler R , Lidman C , Möller A , Popovic B , Rose B , Scolnic D , Smith M , Vincenzi M , Abbott T M C , Aguena M , Allam S , Alves O , Annis J , Bacon D , Bertin E , Bocquet S , Brooks D , Burke D L , Carnero Rosell A , Carrasco Kind M , Carretero J , Costanzi M , da Costa L N , Pereira M E S , Desai S , Diehl H T , Everett S , Ferrero I , Frieman J , García-Bellido J , Gruen D , Gruendl R A , Gschwend J , Gutierrez G , Hinton S R , Hollowood D L , Honscheid K , James D J , Kuehn K , Kuropatkin N , Lewis G F , Mena-Fernández J , Miquel R , Palmese A , Paz-Chinchón F , Pieres A , Plazas Malagón A A , Raveri M , Rodriguez-Monroy M , Romer A K , Sanchez E , Scarpine V , Schubnell M , Sevilla-Noarbe I , Suchyta E , Swanson M E C , Tarle G , Tucker D L , Weaverdyck N ,   DES Collaboration
Published: December 2022

ABSTRACT
Recent analyses have found intriguing correlations between the colour (c) of type Ia supernovae (SNe Ia) and the size of their ‘mass-step’, the relationship between SN Ia host galaxy stellar mass (Mstellar) and SN Ia Hubble residual, and suggest that the cause of this relationship is dust. Using 675 photometrically classified SNe Ia from the Dark Energy Survey 5-yr sample, we study the differences in Hubble residual for a variety of global host galaxy and local environmental properties for SN Ia subsamples split by their colour. We find a 3σ difference in the mass-step when comparing blue (c &lt; 0) and red (c &gt; 0) SNe. We observe the lowest r.m.s. scatter (∼0.14 mag) in the Hubble residual for blue SNe in low mass/blue environments, suggesting that this is the most homogeneous sample for cosmological analyses. By fitting for c-dependent relationships between Hubble residuals and Mstellar, approximating existing dust models, we remove the mass-step from the data and find tentative ∼2σ residual steps in rest-frame galaxy U − R colour. This indicates that dust modelling based on Mstellar may not fully explain the remaining dispersion in SN Ia luminosity. Instead, accounting for a c-dependent relationship between Hubble residuals and global U − R, results in ≤1σ residual steps in Mstellar and local U − R, suggesting that U − R provides different information about the environment of SNe Ia compared to Mstellar, and motivating the inclusion of galaxy U − R colour in SN Ia distance bias correction.
Jets from SANE super-Eddington accretion discs: morphology, spectra, and their potential as targets for ngEHT
Authors: Curd Brandon , Emami Razieh , Anantua Richard , Palumbo Daniel , Doeleman Sheperd , Narayan Ramesh 
Published: December 2022

ABSTRACT
We present general relativistic radiation magnetohydrodynamics (GRRMHD) simulations of super-Eddington accretion flows around supermassive black holes (SMBHs), which may apply to tidal disruption events (TDEs). We perform long duration ($t\ge 81,200\, GM/c^3$) simulations that achieve mass accretion rates ≳11 times the Eddington rate and produce thermal synchrotron spectra and images of their jets. Gas flowing beyond the funnel wall expands conically and drives a strong shock at the jet head while variable mass ejection and recollimation, along the jet axis, results in internal shocks and dissipation. Assuming the ion temperature (Ti) and electron temperature (Te) in the plasma are identical, the radio/submillimetre spectra peak at &gt;100 GHz and the luminosity increases with BH spin, exceeding $\sim 10^{41} \, \rm {erg\, s^{-1}}$ in the brightest models. The emission is extremely sensitive to Ti/Te as some models show an order-of-magnitude decrease in the peak frequency and up to four orders-of-magnitude decline in their radio/submillimetre luminosity as Ti/Te approaches 20. Assuming a maximum VLBI baseline distance of 10 Gλ, 230 GHz images of Ti/Te = 1 models shows that the jet head may be bright enough for its motion to be captured with the EHT (ngEHT) at D ≲ 110 (180) Mpc at the 5σ significance level. Resolving emission from internal shocks requires D ≲ 45 Mpc for both the EHT or ngEHT.
Three-dimensional simulations of advective, sub-Keplerian accretion flow on to non-rotating black holes
Authors: Garain Sudip K , Kim Jinho 
Published: December 2022

ABSTRACT
We study the time evolution of sub-Keplerian transonic accretion flow on to a non-rotating black hole using a three-dimensional, inviscid hydrodynamics simulation code. Prior two-dimensional simulations show that centrifugal barrier in the accreting matter may temporarily halt the nearly free-falling matter and produce a stable, geometrically thick disc that may contain turbulent eddies. Our goal in this work is to investigate whether the disc develops any instability because of this turbulence when we dynamically activate all three dimensions. We find that the disc remains stable and axisymmetric even close to the central black hole. However, if we explicitly apply non-axisymmetric azimuthal perturbation, the axisymmetric structure of the disc is destroyed and instability is developed.
CoLoC-seq probes the global topology of organelle transcriptomes
Authors: Jeandard Damien , Smirnova Anna , Fasemore Akinyemi Mandela , Coudray Léna , Entelis Nina , Förstner Konrad U , Tarassov Ivan , Smirnov Alexandre 
Published: December 2022

AbstractProper RNA localisation is essential for physiological gene expression. Various kinds of genome-wide approaches permit to comprehensively profile subcellular transcriptomes. Among them, cell fractionation methods, that couple RNase treatment of isolated organelles to the sequencing of protected transcripts, remain most widely used, mainly because they do not require genetic modification of the studied system and can be easily implemented in any cells or tissues, including in non-model species. However, they suffer from numerous false-positives since incompletely digested contaminant RNAs can still be captured and erroneously identified as resident transcripts. Here we introduce Controlled Level of Contamination coupled to deep sequencing (CoLoC-seq) as a new subcellular transcriptomics approach that efficiently bypasses this caveat. CoLoC-seq leverages classical enzymatic kinetics and tracks the depletion dynamics of transcripts in a gradient of an exogenously added RNase, with or without organellar membranes. By means of straightforward mathematical modelling, CoLoC-seq infers the localisation topology of RNAs and robustly distinguishes between genuinely resident, luminal transcripts and merely abundant surface-attached contaminants. Our generic approach performed well on human mitochondria and is in principle applicable to other membrane-bounded organelles, including plastids, compartments of the vacuolar system, extracellular vesicles, and viral particles.