bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-fat Diet Enhances the Growth of Renal Cell Carcinoma and Alters Immune Cells in Spleen, Kidney and Tumor
Authors: Zheng Zi Run , Ma Ke , Meng Yu 
Published: July 2023

AbstractRenal cell carcinoma (RCC) is strongly associated with abnormal or excessive fat deposition in the body, whose processes include persistent adipose inflammation and other disturbances with the development and function of immune cells. Researchers have recently become more and more interested in understanding how high-fat diet (HFD) affects the development and course of RCC by causing immunological dysfunction. The changes of immune cell groups in RCC, particularly those in normal kidneys and tumors, are, nevertheless, still poorly understood. Consequently, we explore the effect of HFD on the changes of immune cell groups in spleens, normal kidneys and tumors, mainly revealing the changes of T cells, B cells and NK cells, and further preliminarily exploring the changes of NK cell phenotype. Our findings demonstrate that: 1) HFD speeds up the growth of ACHN tumors; 2) HFD increases the frequency of CD45+live cell, T cell and cNK in spleen, increases the frequency of T cell, NK cell and cNK in normal kidney, as well as increases the frequency of CD45+live cell, NK cell and cNK in tumor;3) HFD decreases the frequency of B cell, NK cell and ILC1 in spleen, decreases the frequency of CD45+live cell, B cell, and ILC1 in normal kidney, as well as decreases the frequency of T cell, B cell and ILC1 in tumor. These data will open up new avenues for immunotherapy in individuals with obese renal cell carcinoma.
Understanding Shifting Paradigms of Translation Studies in 21st Century
Authors: Ali Ghulam , Ali Nusrat , Syed Kazim 
Published: July 2023

Abstract
The study primarily aims at exploring the emerging trends and tendencies; and shifting paradigms in the field of translation studies in the twenty-first century. It also attempts to interpret the emergent tendencies in the field with reference to the present-day technological world. To investigate this shift, it analyzed the literature published on the phenomenon of translation between 2001 and 2022 in the Web of Science (Core Collection). It employs the software tools VOSviewer, Biblioshiny, ScientoPy, and MS Excel, this study seeks to visualize and analyze the data to gain insights into the dominant trends and themes related to translation and its role in cultural dialogue, politics, manipulation, mutual understanding, identity, cultural harmony, representation, discourse, ideology, cultural communication, language, and linguistic. The study after a comprehensive and systematic exploration of massive data found that the phenomenon of translation has undergone a profound metamorphosis, transcending the boundaries of traditional cultural paradigms to embrace the nascent realm of emerging technological paradigms. This paradigm shift has been propelled by groundbreaking advancements in machine translation, neural networks, natural language processing (NLP), and machine learning, heralding a seismic revolution within the translation industry. The fusion of technology and translation has not only redefined the very fabric of translation methodologies but has also exerted a transformative influence on the indispensable skills demanded from experts and scholars.
Respective contributions of intracranial and extracranial injuries in early coagulopathy occurrence following traumatic brain injury.
Authors: Wildenberg Lucille , Rustin Mathilde , Kallout Julien , Moyer Jean-Denis , Esnault Pierre , Pissot Matthieu , Godier Anne , Hanouz Jean-Luc , Geeraerts Thomas , Garrigue Delphine , Léone Marc , Legros Vincent , Audibert Gérard , Clavier Thomas , Abback Paer Sélim , Harrois Anatole , Figueiredo Samy , Group Traumabase 
Published: July 2023

Abstract
Background Following traumatic brain injury (TBI), coagulopathy on hospital admission is reported in 25–35% of patients and associated with increased morbimortality. The respective contributions of intracranial injury and concomitant extracranial lesions to coagulopathy have been poorly investigated. We hypothesized that the occurrence of post-TBI coagulopathy would not only be related to head injury severity, but also and to a greater extent to the presence and severity of the associated extra-cranial injuries.Methods Observational study from a multicenter prospective French trauma registry (Traumabase®). All adult patients directly admitted to one of the participating centers from January 2012 to December 2021 following TBI (AIS (Abbreviated Injury score) head ≥ 1) were included. Post-TBI coagulopathy was defined by at least 1 of the following criteria: prothrombin ratio (Quick %) < 70% or platelet count < 100 G.L− 1 or fibrinogenemia < 1.5 g.L− 1 on hospital admission. Severe associated extracranial lesions were defined by at least 1 of the extra-head AIS scores ≥ 3.Results Among 33875 patients admitted to 22 trauma centers, 9610 patients had TBI and were analyzed. The overall incidence of admission coagulopathy was 28.5%. Coagulopathic patients were significantly more severely injured and especially more severely head-injured, when compared to non-coagulopathic patients. The higher the AIShead, the higher the proportion of patients exhibiting coagulopathy (P < 0.001), whatever the presence of extracranial lesions. When compared to patients with AIShead = 1, the increased incidence of coagulopathy with TBI severity was observed at an earlier stage of TBI severity when severe extracranial lesions were present. In multivariable analysis, severe extracranial injury was independently associated with the risk of post-TBI coagulopathy (OR 2.0 (1.8–2.3), P < 0.001).Conclusions A continuously graded association between the severity of head injury and coagulopathy at hospital admission was observed, and this increased incidence of coagulopathy was observed at an earlier stage of TBI severity when severe extracranial lesions were present. The presence of severe extracranial injuries was one of the most important risk factors for coagulopathy following TBI. Intracranial and extra-cranial injury severity could be used to timely identify TBI patients most likely to present post-traumatic coagulopathy, that could benefit from early specific hemostatic resuscitation.
Direct spatiotemporal manipulation mechanism to generate spatiotemporally coupled ultrafast light fields
Authors: Xu Shixiang , Lin Qinggang , Feng Fu , Cai Yi , Lu Xiaowei , Zeng Xuanke , Wang Congying , Li Jingzhen , Yuan Xiaocong 
Published: July 2023

Abstract
Manipulation of spatiotemporally coupled (STC) light fields has gathered considerable interest over the last decade. The manipulation is generally performed in spectrum-space domain rather than time-space domain for the Fourier correlated natures of the time and spectrum domains because ultrafast light fields evolve so rapidly that no light modulator can keep pace with them. Spectrum-space manipulation using a 4-f pulse shaper has proved particularly successful, but suffers from limited spectral and pixel resolutions, plus information crosstalk from the spectral modulation in spectrum-space plane. To overcome these flaws, an innovative mechanism is proposed for direct time-space manipulation of an ultrafast light field, which involves introducing a space-dependent time delay and then performing spatial manipulation by a geometrical transformation. As an experimental verification, based on this mechanism, a high-quality STC light spring has been experimentally generated with a topological charge bandwidth as broad as 11.5 and a tunable central topological charge from 2 to − 11. Furthermore, the light spring can propagate with a stable spatiotemporal intensity structure and a basically invariant rotation period from the near field to the far field, which is critically important for its further manipulation and applications. This work provides an efficient way to generate complex spatiotemporal beams such as light springs, which have applications including information encryption, optical communication, and laser-plasma acceleration.
TiO 2 Coated SiO 2 Core-Shell Stationary Phase with Uniform and Tunable TiO 2 Thickness for High Performance Liquid Chromatography Separation
Authors: Wang Jiafei , Wan Xiang , Li YingYing , Mangelings Debby , Xie Fazhi , Huang Xianhuai , Li Weihua , Zhao Donglin , Qu Qishu 
Published: July 2023

Abstract

In this work, TiO2 was coated into the pores of the SiO2 core-shell spheres by using tetrabutyl orthotitanate (TBOT) as the titanium source. Then, by simply prolonging the reaction time, a TiO2 layer with a uniform and controllable thickness was obtained on the surface of SiO2 core-shell spheres by Ostwald ripening. The thickness of the TiO2 layer can be tuned from 15 to about 71 nm by either controlling the reaction time or controlling the amount of TBOT. C18-derived core-shell spheres with a TiO2 layer thicknesses of 40 nm (C18-SST-0.5-60) and 70 nm (C18-SST-0.7-30) were used as packings to evaluate the effect of TiO2 layer thickness on the chromatographic separation performance. The separation efficiency of C18-SST-0.5-60 and C18-SST-0.7-30 for fluorene was 115112 plates m− 1 and 83189 plates m− 1, respectively. Both TiO2-coated core-shell packings showed good peak symmetry for basic samples, with peak asymmetry factors below 1.11. The relative standard deviations of the retention time of polycyclic aromatic hydrocarbons and anilines were all lower than 6%. The results demonstrate that the TiO2 based stationary phase possesses great potential for high performance liquid chromatographic separation.
Incidence and risk factors of inguinal hernia after robot-assisted radical prostatectomy: a retrospective multicenter cohort study in Japan (the MSUG94 group)
Authors: Toide Masahiro , Ebara Shin , Tatenuma Tomoyuki , Ikehata Yoshinori , Nakayama Akinori , Kawase Makoto , Sasaki Takeshi , Yoneda Tatsuaki , Sakaguchi Kazushige , Teishima Jun , Makiyama Kazuhide , Kitamura Hiroshi , Saito Kazutaka , Koie Takuya , Inoue Takahiro , Urakami Shinji , Koga Fumitaka 
Published: July 2023

Abstract
Purpose: To investigate the incidence and risk factors of inguinal hernia (IH) after robot-assisted radical prostatectomy (RARP) using a multicentric database.
Methods: The present study used a multicentric database (the MSUG94) containing data on 3,195 Japanese patients undergoing RARP between 2012 and 2021. Surgical procedures utilized for IH prevention were as follows: isolation of the vas deferens, transection the vas deferens, isolation of the spermatic vessels, and separation of the peritoneum from the internal inguinal ring. The primary and secondary endpoints were IH-free survival and any association between post-RARP IH and clinical covariates. The prophylactic effect of the above procedures were also assessed.
Results: IH prevention was attempted in 1,465 (46.4%) patients at five of the nine hospitals. During follow-up (median 24 months), post-RARP IH developed in 243 patients. The post-RARP IH-free survival rate at year 1, 2, and 3 was 94.3%, 91.7%, and 90.5%, respectively. Old age (hazard ratio [HR]: 1.037; 95% confidence interval [CI]: 1.014-1.061; p = 0.001), low BMI (HR: 0.904; 95% CI: 0.863-0.946: p <0.001), and low hospital volume (HR: 1.385; 95% CI: 1.003-1.902; p = 0.048) were independently associated with IH development. None of the procedures for IH prevention were associated with IH development.
Conclusion: Our findings may represent the current, real-world status of post-RARP IH in Japan. The prophylactic effects of the surgical procedures for IH prevention should be further investigated in well-designed, prospective studies to optimize the surgical technique.
Phase segregation in La-doped YIG: Influence of temperature
Authors: Souza F. R. , Tavares E. L. , Soares João M. , Silva R. B. da , Peña-Garcia R. , Padrón-Hernández E. 
Published: July 2023

Abstract
Herein, we present a study about the calcination temperature effect on the structural and magnetic properties of the Y3Fe5-xLaxO12 compound. The refinement of the X-ray diffraction patterns confirmed the YIG single phase formation for sample calcined at 900°C, while for the samples sintered at 1000°C and 1100°C, it was verified the phase segregation belonging to the YFeO3 compound. The average crystalline size increases with the temperature, which may be related to the nucleation and growth mechanisms that are favored by temperature. The samples have an agglomerated morphology and an irregular elongated shape. The magnetic properties show variation in the magnetic moment of the compound as the phase formation temperature increases. At temperatures of 1000°C and 1100°C, the effects of the secondary phase are added to the magnetism of the compound, causing variations in the saturation magnetization and in the effective anisotropy field.
Comparison between intra-lesional steroid injection versus autologous platelet-rich plasma therapy following surgical excision of aural keloid (Difference in effectiveness of intra lesional steroids and PRP for aural keloid treatment)
Authors: Awan Nukhbat ullah , Fida Tooba , Waheed Khadija , FCPS Uzma Malik , Aslam Ayesha , Mehmood Khansa , ul Zain , Sadiq Sauban Mansoor 
Published: July 2023

Abstract

Background: Keloids are benign growth of dense fibrous tissues from an abnormal healing response to a cutaneous injury, extending beyond the original borders of the wound. Intralesional triamcinolone acetonide (TA) is their first-line therapy, but commonly associated with side effects or recurrence. Platelet rich plasma (PRP) is an autologous blood-derived product with promising results in improving wound healing with lower keloid occurrence.Objective:To compare the efficacy of TA versus PRP in treatment of Aural keloid after excision.Place and Duration of Study:The department of Ear, Nose and Throat and Head and Neck Surgery, King Edward Medical University, Mayo Hospital, Lahore, from January 2021 to October 2021.Study Design:Randomized controlled trialMethods:Patients with aural keloids type I and II were enrolled in the study. 84 patients with aural keloids were divided randomly into two equal groups, A and B. Patients with aural keloids only type I and type II (acc. To Chang Park classification) and Patients without prior treatment were included and those presenting with Hypertrophic scars, Type III, IV, V (in accordance to Chang Park classification) and Pregnancy were excluded in our study. Group A received intralesional TA (20 mg/ml) after excision for 4 sessions, first on the day of surgery rest 3 sessions 1 week apart. Group B patients received intralesional PRP after excision in 4 sessions similar to TA. Evaluation was done after 3 months by The Patient and Scar Observer Assessment Scale (PSOAS).ResultsOf the 84 patients included in our study all 84 were females, having mean age around 22-23 years with 72% of them being unmarried. The mean scores of POSAS Patient scale for pain was found to be 15.65 in grp A and 27.23 in grp B, with color having mean score of 19.76 (grp A) and 27.24 (grp B), itching 19.5 (grp A) and 27.8 (grp B), stiffness 19.83 (grp A) and 27.8 (grp B), thickness 19.36 (A) and 28.81 (B), irregular scar 19.47 (A) and 27.3 (B). There was statistically significant improvement in all parameters of PSOAS of group B patients with their mean consistently being lower than group A patients i.e those receiving TA. Both groups had similar complications which were minor with hyperpigmentation being most of it all.Conclusion:We concluded that PRP is superior in preventing recurrence of aural keloid after surgical excision.
Inter-plot competition in hybrid maize multi-environment yield trials in Ethiopia can reduce rate of genetic gain
Authors: Keno Tolera , Mace Emma , Godwin Ian , Jordan David , Kelly Alison 
Published: July 2023

Abstract
Conducting large-scale multi-environment trials (METs) is practically challenging to breeding programs in Sub-Saharan Africa due to limitations of land, seed, and associated costs of phenotyping. As a result, early-generation hybrid maize trials are usually planted with single-row plots. In trials with single-row plots, genotypes compete with their neighbors for resources, and this biases the prediction of the genotype value. We demonstrate the impact of inter-plot competition in single-row multi-environment hybrid maize trials in Ethiopia through a motivating example assessing subsets of 478 maize hybrids in six trials in the 2019 and 2020 main season. The trials were planted in partially replicated design with single-row plots. Field spatial variability and inter-plot competition were jointly modelled in a linear mixed model framework to partition the total genetic effect into direct and neighbour effects. Both direct and neighbour genetic effects differed across the trials confirming the presence of genotype by environment interaction (GEI) for these genetic components. There was a rank change in genotype performance between the selections from the competition model in comparison to the standard MET model. The proportion of mismatch in the top 20% of the selected genotypes from the competition model and the standard MET model ranged from 20 – 70 % across the optimum nitrogen sites and up to 90 % in the low nitrogen site. The results demonstrated that inter-plot competition biases grain yield predictions in single-row plot hybrid maize METs and thus reduces the rate of genetic gain, if not accounted for using appropriate statistical models.
ARPC3 affects the prognosis of patients with hepatocellular carcinoma by regulating the immune response
Authors: Song Yonghu , Li Jianhui , Lu Zhenyang , Qi Yijun 
Published: July 2023

Abstract
Background
ARPC3 is associated with poor prognosis in patients with various cancers. However, the mechanisms by which it affects immunotherapy and prognosis in patients with hepatocellular carcinoma (HCC) remain unclear.
Method
The expression difference in ARPC3 between normal and HCC tissues and the effect of ARPC3 on prognosis were evaluated by using multiple databases. GSEA was used to predict the pathway by which ARPC3 affects HCC progression. Using TCGA database, the First Affiliated Hospital of Anhui Medical University (AHMU) database and ICGC database, the correlation between ARPC3, tumor infiltrating lymphocytes (TILs) and immune checkpoints was studied. To explore the effect of ARPC3 on immune checkpoint inhibitors (ICIs), We investigated the association of ARPC3 with immunotherapy-associated ferroptosis genes.
Results
The expression of ARPC3 in normal tissues was lower than that in tumor tissues, and as an independent prognostic risk factor for HCC, patients with HCC whose ARPC3 expression was high had a worse prognosis. GSEA suggested that the upregulation of ARPC3 mainly affected immune-related pathways. Three databases showed that ARPC3 expression levels affected the infiltration levels of B cells, T cells, macrophages, neutrophils, and NK cells in tumors. In addition, we confirmed that ARPC3 may influence the efficacy of ICI therapy by influencing the expression of immune checkpoints and ferroptosis-related genes in HCC.
Conclusions
ARPC3 is an independent prognostic risk factor for HCC patients and may influence the immunotherapy of HCC by influencing the expression of immune checkpoints and ferroptosis-related genes.
The distal resection of the rectal pouch in laparoscopic-assisted anorectoplasty for males with anorectal malformation: 153 cases’ experience in a single center
Authors: ye shiru , Zhou Yan , Zheng Chen , Li Siqi , Hu Wenshu , Gao Ruyue , Diao Mei , Li Long 
Published: July 2023

Abstract
Purpose This study aimed to evaluate the factors associated with constipation and the efficacy of the distal resection length (DRL) of not less than 3cm in males with anorectal malformation (ARM).
Methods Demographic, associated anomalies, clinical features, and the bowel function of the males with ARM and rectourethral/rectovesical fistula (RUF/RVF) were evaluated. The Krickenbeck scores were used to assess bowel function. Univariate and multivariate analysis were used to identify factors associated with constipation. The bowel function was evaluated between the groups categorized by DRL after 1:1 propensity score matching (PSM).
Result A total of 153 males with a median follow-up period of 6 years, 54(35.2%) suffered from constipation. Multivariate analysis revealed that the DRL (OR = 0.68, P = 0.007) is the only independent protective factor of constipation after potty training. After PSM, 35 patients were included in each of the groups categorized by DRL≥3.0cm and DRL＜3cm, and the patients were well-balanced. No significant differences between groups were noted in postoperative complications (11.4% vs. 25.7% P = 0.218) and constant soiling (17.1% vs. 31.4%, P = 0.718). However, the incidence of constipation in the DRL≥3.0cm group was significantly lower than that in the DRL＜3cm group(37.1% vs. 71.4%, P = 0.028).
Conclusion The longer distal resection was the independent protective factor for constipation, suggesting that the excessive preservation of the rectal pouch is the cause of constipation. And the constipation rate in ARM with DRL ≥3cm was significantly lower without increment of soiling after PSM, which may be associated with the fibrosis in the last 3cm of the rectal pouch. Thus, not less than 3cm of the rectal pouch is recommended to resect in males with ARM.
A window-based multi-scale attention model for slope collapse detection
Authors: Pan Yuchen , Xu Hao , Qian Kui , Li Zhenyan , Yan Hong 
Published: July 2023

Abstract
Slope collapse detection is a critical foundation for defending against water flow impact and maintaining shoreline stability. Under realistic detection conditions such as difficult collection of actual defect samples and complex target environment, addressing the problem of existing deep learning techniques with low recognition accuracy, a window-based multi-scale attention model for slope collapse detection called Faster-Swin is proposed. The traditional convolutional neural network (CNN) architecture has been enhanced by incorporating skip connection structures such as Elan block and SPPC block, which alleviate the problem of gradient vanishing that arises from increasing depth in deep neural networks. Then the window-based multi-scale attention mechanism is added to the backbone network to increase the overall modeling ability of the model and reduce the computational cost. Experimental results show that Faster-Swin can adapt to complex backgrounds in low-quality datasets, and the final mean average precision (map) value can reach 97.16\%
A Novel Approach To The Transformation of Pyrazole-4-Carbonitriles to Novel 3-Aryl-1-Phenyl-1H-Pyrazole-4-Carbothioamide Using Thioacetamide as a Sulfur Source
Authors: Choudhare Tukaram S. , Wagare Devendra S. , Pawar Sangita , Netankar Prashant 
Published: July 2023

Abstract
New protocol designed for the synthesis of novel pyrazole-4-carbothioamide by the reaction of pyrazole-4-carbonitrile using thioacetamide in the presence of Amberlyst-15 as a catalyst in ethanol. Various methods are adopted for the synthesis of 3-Aryl-1-phenyl-1H-pyrazole-4-carbothioamides such as Amberlyst-15 method, Citric acid method, BF3-Etherate method and Dowex DR-2030 method. But Amberlyst-15 method offered highly pure product with excellent yield. Here, thioacetamide employed as sulfur source and avoid use of hazardous Lawesson’s Reagent, Na2S, H2S gas. Novel Pyrazole-4-Carbothioamides are synthesized and characterized by using 1H NMR, 13C NMR and Mass spectral techniques. It’s a rapid, single step and clean synthetic protocol for the synthesis of Pyrazole-4-carbonitriles with excellent yield (97-99%).