bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of spray drying conditions on physicochemical and functional properties of apple cider vinegar powder
Authors: Altay Ipek , Reimer Stubbe Peter , Mohammadifar Mohammad Amin 
Published: May 2023

AbstractBackgroundApple cider vinegar (ACV) contains many health benefits due to its antioxidant and acetic acid content. However, the adverse effects of directly consuming the vinegar should be eliminated to make it possible to regulate its intake as a dietary supplement. The objective of the study is to optimize the spray drying operating conditions to produce ACV powder with health benefits. A central composite design (CCD) of response surface methodology (RSM) was used to optimize the spray drying process of ACV. The influences of inlet temperature (130°C–170°C), gum Arabic concentration (5%–15% w/w), and feed flow rate (1–2 kg/h) on some product and process aspects were investigated. Spray‐dried powders were evaluated for their moisture content, process yield, acetic acid content, solubility, and antioxidant content.ResultsThe relationships between the model factors and final powder properties were established with ANOVA and multiple regression analysis. The model factors affected the investigated powder properties at different significance levels, where carrier concentration was the main influencing factor. Gum Arabic contributed to the retention of volatile and heat‐sensitive compounds providing health benefits. All powders showed high solubility (>94%) and high antioxidant recovery, and most treatments achieved a drying yield of higher than 50%.ConclusionOptimization of spray drying process was achieved with application of RSM and relationships between model factors and powder properties were established. This study highlighted the feasibility of the development of ACV‐based functional powder as a dietary supplement.
Closed‐tube visual detection of Atlantic cod (Gadus morhua) using self‐quenched primer coupled with a designed loop‐mediated isothermal amplification vessel
Authors: Hanyue Xue , Yanjin Fei , Shihui Wang , Yao Lili , Xiong Xiong , Ying Yang 
Published: May 2023

AbstractBACKGROUNDSpecies adulteration has been widely revealed around the world, and the possible reasons include declining stocks in most source areas of the world, poor transparency in the global supply chain, and difficulty in distinguishing the features of processed products. The present work selected Atlantic cod (Gadus morhua) as a case study, and developed a novel loop‐mediated isothermal amplification (LAMP) assay for Atlantic cod authentication, where a self‐quenched primer and a newly designed reaction vessel were used to realize the endpoint visual detection of the target‐specific products.RESULTSA novel LAMP primer set was designed for Atlantic cod, and the inner primer BIP was selected to label the self‐quenched fluorogenic element. The fluorophore's dequenching only occurred along with LAMP elongation for the target species. No fluorescence could be observed with both single‐stranded DNA and partially complementary dsDNA of the non‐target species. With the novel reaction vessel, both amplification as well as detection were operated in an enclosed device, and visual differentiation of Atlantic cod, negative control, and false positive generated from primer dimers was achieved. The novel assay has proved its specificity and applicability, and could detect as little as 1 pg of Atlantic cod DNA. Moreover, Atlantic cod adulteration as low as 10% could be detected in haddock (Melanogrammus aeglefinus), and no cross‐reactivity was observed.CONCLUSIONThe established assay could be a useful tool to detect mislabeling incidents involving Atlantic cod considering the advantages of speed, simplicity and accuracy. © 2023 Society of Chemical Industry.
Effects of gamma irradiation on the sensory and metabolic profiles of two peach cultivars
Authors: Pieroni Victoria , Ottaviano Fernanda Gugole , Sosa Miriam , Gabilondo Julieta , Budde Claudio , Colletti Analía C. , Denoya Gabriela , Polenta Gustavo , Bustamante Claudia , Müller Gabriela , Pachado José , Andres Silvina C , Cardinal Paula , Rodriguez Graciela , Garitta Lorena 
Published: May 2023

AbstractBACKGROUNDThe suitability of commercial peaches for minimal processing (MP) is limited, mainly due to shortened shelf‐life. Gamma irradiation has emerged in MP fruits as a promising technology. This study aimed to investigate the effects of gamma irradiation on the sensory and metabolic profiles of MP peaches from two cultivars – ‘Forastero’ (FT) and ‘Ruby Prince’ (RP) – and evaluate the relationship between both profiles. MP peaches were packaged and divided into two groups: one without additional treatment (K) and the other subjected to gamma irradiation (1.0 kGy, I‐ irradiation treatment), making a total of four samples (FTK, FTI, RPK and RPI). The sensory profile was carried out by an assessor panel. Metabolite analysis was accomplished by gas chromatography–mass spectrometry.RESULTSIrradiation significantly affected color, homogeneity, peach aroma, total flavor intensity, peach flavor, sweetness and juiciness in FT, increasing their intensities. In the RP cultivar, irradiation increased brightness, total aroma intensity, peach aroma, and flavor and texture descriptors. Regarding metabolites, only malic acid and sucrose increased their concentrations in the irradiated samples. Partial least squares showed that sucrose was mainly correlated with sweet, total aroma intensity and peach flavors, and linked with FTI sample. Bitter along with peach aroma and total intensity flavor were associated with RPI sample.CONCLUSIONThe applied dose accelerated the ripening process of the peach. The study highlights the importance of complementing sensory analysis with metabolomics tools to optimize fruit quality in minimally processed peaches. © 2023 Society of Chemical Industry.
Identifying Core Journals in Otolaryngology: A Bibliometric Analysis
Authors: Meller Leo L.T. , Vasudev Milind , Bui Anh‐Tram , Wang Jenny , Kuan Edward C. , Tjoa Tjoson , Haidar Yarah M. 
Published: May 2023

ObjectivesAs research in otolaryngology continues to expand rapidly, it is important to identify core journals to keep clinicians updated with the latest advances. This study is the first to characterize core journals in otolaryngology.MethodsUsing h‐index and impact factor (IF), the top 15 NLM‐indexed otolaryngology journals were selected for analysis. The references from all articles published in these journals in one randomized quarter were compiled into a citation rank list, with the most cited journal ranked the highest. Citation zonal distribution analysis was conducted to identify the zonal distribution of otolaryngology journals.ResultsA total of 3150 journals containing 26876 articles were cited in otolaryngology literature in April–June 2019. Laryngoscope was the most cited journal containing 1762 citations. IF is significantly associated with the h‐index for the top 10 otolaryngology journals (p = 0.032). Three core journal zones were identified, with Zone 1 containing 8 journals, Zone 2 containing 36 journals, and Zone 3 containing 189 journals. A linear relationship between the log journal rank for Zones 1–3 and a cumulative number of citations was found (R2 = 0.9948).ConclusionEight core journals for otolaryngology were identified: Laryngoscope, Otolaryngology—Head and Neck Surgery, Otology & Neurotology, JAMA Otolaryngology—Head & Neck Surgery, Head & Neck, European Archives of Oto‐Rhino‐Laryngology, International Journal of Pediatric Otorhinolaryngology, Annals of Otology, Rhinology & Laryngology. In the face of rapidly evolving research and a multitude of journals, the high citation density within these core journals highlights their utility in updating busy clinicians.Level of EvidenceNA Laryngoscope, 133:3346–3352, 2023
Reconstruction of finger contracture with an expanded first dorsal metacarpal artery perforator flap: A case report
Authors: Özkan Burak , Tatar Burak Ergün , Savran Süleyman , Albayati Abbas , Uysal Cagri Ahmet 
Published: May 2023

AbstractVolar finger contractures can be challenging for plastic surgeons. The dorsal metacarpal artery perforator (DMCAP) flap is frequently used to cover bones, tendons, and neurovascular structures in the dorsum of the hand after trauma and burns as an alternative to grafts and free flaps. We aimed to report volar finger defect reconstruction with expanded DMCAP flap. A 9‐year‐old male patient applied to our clinic with the complaint of inability to open the second finger of the left hand after an electrical burn that caused proximal and distal interphalangeal joints flexion contractures. Reconstruction was planned for the patient with a two‐session expanded first DMCAP flap. A 16 mL 5 × 3 cm tissue expander was placed in the prepared area from the vertical incision in the first session. The tissue expander was inflated with 4 mL of isotonic solution. The DMCA area was enlarged 6 weeks later by giving 22 mL of isotonic solution. After the pedicle dissection, the 9 × 3 cm DMCAP flap was elevated by dissection over the paratenon. With 180° of rotation, the left‐hand second finger was adapted to the 6 × 2 cm defect area on the volar face. The flap donor site was closed primarily. The operation was terminated by placing the hand on a protective splint. There were no complications in the flap in the postoperative 6 months. The patient was referred to the physical therapy and rehabilitation department. As a result, an expanded DMCAP flap may cover volar tissue defects up to the distal phalanx. This report may present the first case in which volar finger contracture reconstruction was performed with an expanded first DMCAP flap after an electrical burn in a pediatric patient.
Promoting health and preventing malnutrition among children in rural Bangladesh: A qualitative study
Authors: Westerbotn Margareta , Monfors Felicia , Reusser Julia , Tyrrell Marie 
Published: May 2023

AbstractAimTo describe community healthcare professionals' experiences of preventing malnutrition among children in rural Bangladesh.MethodsA descriptive qualitative study with a total of seven healthcare professionals were recruited from a non‐governmental organisation in rural Bangladesh. Individual in‐depth interviews were conducted in November 2018 using a semi‐structured interview guide. The audio‐recorded interviews were transcribed verbatim and analysed manually using content analysis.ResultsThe data analysis resulted in two main categories: Implementation and practices in preventing malnutrition and Challenges in working with prevention of malnutrition. Education was considered an important and essential preventative intervention. Healthcare professionals faced challenges in their work in relation to socio‐cultural and climate factors. The findings indicate how healthcare professional identified the need for increased knowledge and resources in the community to promote nutritional health in children.
Health care providers' attitudes and counseling behaviors related to obesity
Authors: Smith Marjanna , Gallagher Christine , Weber Deanne , Dietz William H. 
Published: May 2023

AbstractBackgroundObesity affects over 42% of the U.S. adult population, yet it remains undertreated. Many healthcare providers are biased in their perceptions and attitudes regarding obesity management and lack knowledge about how to treat it.MethodsThe authors analyzed the results of the 2021 DocStyles survey to examine primary care providers' treatment and perceptions of obesity. The sample consisted of primary care physicians and nurse practitioners/physician assistants. Questions assessed healthcare providers' attitudes and counseling behaviors related to obesity, including referrals, use of medical therapy, barriers to care, and perceived risk factors for obesity.Results1168 primary care providers who treat obesity participated in the survey. About half of the providers reported referring patients for obesity treatment. Almost two‐thirds of providers had prescribed anti‐obesity medications in the last 12 months. Those who did not prescribe anti‐obesity medications reported a lack of familiarity with the medications or concerns about safety. Over three‐quarters of providers indicated at least one barrier to treating obesity. Over half of the providers reported that poverty and food insecurity contributed significantly to the high prevalence of obesity in communities of color.ConclusionIncreased familiarity with anti‐obesity medications may improve treatment. Reasons for patients' low priority accorded to obesity care remain the focus of future research.
Centring justice in conceptualizing and improving access to urban nature
Authors: Langhans Kelley E. , Echeverri Alejandra , Daws S. Caroline , Moss Sydney N. , Anderson Christopher B. , Chaplin‐Kramer Rebecca , Hendershot J. Nicholas , Liu Lingling , Mandle Lisa , Nguyen Oliver , Ou Suzanne X. , Remme Roy P. , Schmitt Rafael J. P. , Vogl Adrian , Daily Gretchen C. 
Published: May 2023

AbstractAs humanity has become increasingly urban, a growing number of people have been deprived of access to nature and the benefits it provides. This is especially true for marginalized groups, who often live in neighbourhoods where nature has been so diminished and degraded that it provides fewer types, and much lower levels of benefits.We review the literatures on human–nature relationships, urban sustainability and justice to create an actionable definition of ‘access to nature’ that people can use to advocate for and guide investments that improve access to nature in urban contexts.We show how the interplay of three dimensions of justice—recognitional, procedural and distributional—determines access to nature in cities, and how these dimensions are core to increasing access to urban nature.We present a design thinking framework that centres justice in creating interventions for access to nature, together with questions that can guide the process of designing and implementing new interventions.Lastly, we illustrate how our framework can be operationalized by showcasing three case studies that improve access to nature to marginalized communities in the United States: Latino Outdoors, Sogorea Te′ Land Trust and the Nature Imagery in Prisons Project.We conclude by re‐affirming the importance of centring justice in improving access to nature, so that all people can enjoy the benefits that nature provides and lead healthy, fulfilling lives.Read the freePlain Language Summaryfor this article on the Journal blog.
Correlation between heparin anti‐Xa activity and thromboelastography in adult critically ill COVID‐19 patients
Authors: Buckley Mitchell S. , Benanti Grace E. , Gilbert Brian , Meckel Jordan , Dzierba Amy L. , MacLaren Robert 
Published: May 2023

AbstractStudy ObjectiveSevere coronavirus disease 2019 (COVID‐19) increases the risk of thrombotic complications with unfractionated heparin (UFH) as a commonly used agent in managing venous thromboembolism (VTE). The optimal anticoagulation intensity and monitoring parameters in intensive care unit (ICU) COVID‐19 patients remains controversial. The primary study aim was to evaluate the relationship between anti‐Xa and thromboelastography (TEG) reaction (R) time in patients with severe COVID‐19 receiving therapeutic UFH infusions.DesignSingle‐center, retrospective study conducted over a 15‐month period (2020–2021).SettingAcademic medical center (Banner University Medical Center Phoenix).PatientsAdult patients with severe COVID‐19 administered therapeutic UFH infusions with one or more corresponding TEG, and anti‐Xa assessments drawn within ≤2 hours of each other were included. The primary end point was the correlation between anti‐Xa and TEG R time. Secondary aims were to describe the correlation between activated partial thromboplastin time (aPTT) and TEG R time, as well as clinical outcomes. Pearson's coefficient was used to evaluate the correlation using a kappa measure of agreement.
Proteomics evaluation of five economical commercial abundant protein depletion kits for enrichment of diseases‐specific biomarkers from blood serum
Authors: Ahsan Nagib , Fornelli Luca , Najar Fares Z. , Gamagedara Sanjeewa , Hossan Mohammad Robiul , Rao R. Shyama Prasad , Punyamurtula Ujwal , Bauer Andrew , Yang Zhibo , Foster Steven B. , Kane Maureen A. 
Published: May 2023

AbstractBlood serum is arguably the most analyzed biofluid for disease prediction and diagnosis. Herein, we benchmarked five different serum abundant protein depletion (SAPD) kits with regard to the identification of disease‐specific biomarkers in human serum using bottom‐up proteomics. As expected, the IgG removal efficiency among the SAPD kits is highly variable, ranging from 70% to 93%. A pairwise comparison of database search results showed a 10%–19% variation in protein identification among the kits. Immunocapturing‐based SAPD kits against IgG and albumin outperformed the others in the removal of these two abundant proteins. Conversely, non‐antibody‐based methods (i.e., kits using ion exchange resins) and kits leveraging a multi‐antibody approach were proven to be less efficient in depleting IgG/albumin from samples but led to the highest number of identified peptides. Notably, our results indicate that different cancer biomarkers could be enriched up to 10% depending on the utilized SAPD kit compared with the undepleted sample. Additionally, functional analysis of the bottom‐up proteomic results revealed that different SAPD kits enrich distinct disease‐ and pathway‐specific protein sets. Overall, our study emphasizes that a careful selection of the appropriate commercial SAPD kit is crucial for the analysis of disease biomarkers in serum by shotgun proteomics.
Curcumin as a therapeutic agent in cancer therapy: Focusing on its modulatory effects on circularRNAs
Authors: Si Lihui , Zhang Lina , Xing Shaoliang , Fang Panke , Tian Xiu , Liu Xiaoyan , Xv Xiaohong 
Published: May 2023

AbstractCurcumin, a natural polyphenol compound, has been identified as an effective therapeutic agent against cancer that exerts its anti‐tumor activities by up/downregulating signaling mediators and modulating various cellular processes, including angiogenesis, autophagy, apoptosis, metastasis, and epithelial–mesenchymal transition (EMT). Since almost 98% of genomic transcriptional production is noncoding RNAs in humans, there is evidence that curcumin exerts therapeutic effects through the alterations of noncoding RNAs in various types of cancers. Circular RNAs (circRNAs) are formed by the back‐splicing of immature mRNAs and have several functions, including functioning as miRNA sponges. It has been shown that curcumin modulated various circRNAs, including circ‐HN1, circ‐PRKCA, circPLEKHM3, circZNF83, circFNDC3B, circ_KIAA1199, circRUNX1, circ_0078710, and circ_0056618. The modulation of these circRNAs targeted the expression of mRNAs and modified various signaling pathways and hallmarks of cancer. In this article, we reviewed the pharmacokinetics of curcumin, its anti‐cancer activities, as well as the biology and structure of circRNAs. Our main focus was on how curcumin exerts anti‐cancer functions by modulating circRNAs and their target mRNAs and pathways.
Bidimensional climatology and trends of Northern Hemisphere blocking utilizing a new detection method
Authors: Li Muyuan , Luo Dehai , Simmonds Ian , Yao Yao , Zhong Linhao 
Published: May 2023

AbstractIn this article, the meridional gradient of daily potential vorticity (PV) on the 330 K isentropic surface is used to identify atmospheric blocking events for the period 1979–2019. The associated two‐dimensional index considers not only Rossby wave breaking, but also energy dispersion and nonlinearity of blocking systems, and thus has a solid theoretical foundation. It also has the advantage of automatically excluding subtropical high‐pressure systems in summer and autumn. The index reveals that the Northern Hemisphere exhibits high blocking frequency over Euro‐Atlantic, North Pacific and Greenland in winter, spring and autumn, and over two wide‐extended bands at high latitudes in summer. Two prominent blocking episode (BE) intensity centres are found over the eastern Atlantic and eastern Pacific in all seasons, while the long‐lived BE is primarily situated in regions with high BE frequency. There is more frequent and longer‐lived BE in the Euro‐Atlantic sector than in the North Pacific, whereas the BE in the North Pacific is more intense. Notably, with the same poleward criterion for the four seasons, the BE frequency and duration are supposed to be overestimated in summer. Comparing our blocking detection method with previous blocking indices provides additional information about the long‐term trends for blocking frequency and intensity, which can be useful to our understanding of future extremes on climate time‐scales. It is found that both blocking frequency and intensity exhibit upward linear trends in the Ural region and Barents–Kara Sea in winter, Europe, northern North Pacific and East Siberia in spring, western Greenland in summer, as well as Norwegian Sea, Europe and North Atlantic in autumn, which point to increases in high‐impact weather events in these regions.
Contributions of enterprise architecture to software engineering: A systematic literature review
Authors: Martínez‐López José Antonio , García Félix , Ruiz Francisco , Vizcaíno Aurora 
Published: May 2023

AbstractEnterprise architecture is a growing trend that aims to help deal with the complexity of socio‐technical systems such as human organizations, as well as their information technology and systems areas. Nevertheless, the contribution of enterprise architecture to the field of software engineering remains unclear. The purpose of this systematic literature review is to see how enterprise architecture is used in software development and maintenance practice. To this end, we first carried out a search in the SCOPUS database and then organized the papers according to the Software Engineering Body of Knowledge to determine what areas of software engineering are covered by each research study. To understand how enterprise architecture is used, we established a classification based on ISO 42010 and TOGAF. From the systematic literature review, we noticed that the early stages of development are the most impacted by the enterprise architecture. On the other hand, we observed that enterprise architecture is of assistance in the areas of engineering management, engineering processes, and engineering models and methods; these tasks are carried out by teams or managers using different, often agile, development methods or standards. In turn, we found that the most common categories are architecture descriptions; these are often used to facilitate communication and information‐sharing between different stakeholders, in addition to frameworks, which will help to establish common practices in the organization related to the joint use of enterprise architecture and software development.