bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sculptra®—History and how it is best used today
Authors: Eason Chelsea , Snyder Alan , Favre Clint , Schlesinger Todd 
Published: May 2023

AbstractIntroductionSculptra® is an injectable biostimulatory soft tissue filler containing microparticles of poly‐L‐lactic acid (PLLA) that is FDA‐approved for the correction of HIV‐associated facial lipoatrophy and nasolabial fold contour deficiencies and other facial wrinkles in immunocompetent patients. Injectable PLLA has been shown to provide gradual improvement in cutaneous thickness by inciting a subclinical inflammatory response that stimulates increased collagen deposition in the dermis, with results lasting up to 2 years.DiscussionThe utilization of Sculptra® in aesthetics has expanded to many off‐label indications including panfacial revolumization, improvement in skin quality, and use in various non‐facial sites such as the neck/décolleté, abdomen, arms, hands, thighs, and gluteal area. Clinical experience and scientific investigation have driven changes in the way PLLA is used. Simpler methods of product preparation, improved injection techniques, and attention to appropriate patient selection have led to improved outcomes and ease of use.ConclusionPLLA's long safety history and ability to produce subtle yet significant results through a biostimulatory mechanism make it an attractive and versatile option for cutaneous volume augmentation.
Clinical and biomechanical effectiveness of foot‐ankle exercise programs and weight‐bearing activity in people with diabetes and neuropathy: A systematic review and meta‐analysis
Authors: van Netten Jaap J. , Sacco Isabel C. N. , Lavery Lawrence , Monteiro‐Soares Matilde , Paton Joanne , Rasmussen Anne , Raspovic Anita , Bus Sicco A. 
Published: May 2023

AbstractBackgroundMost interventions to prevent foot ulcers in people with diabetes do not seek to reverse the foot abnormalities that led to the ulcer. Foot‐ankle exercise programs target these clinical and biomechanical factors, such as protective sensation and mechanical stress. Multiple RCTs exist investigating the effectiveness of such programs, but these have never been summarised in a systematic review and meta‐analysis.MethodsWe searched the available scientific literature in PubMed, EMBASE, CINAHL, Cochrane databases and trial registries for original research studies on foot‐ankle exercise programs for people with diabetes at risk of foot ulceration. Both controlled and non‐controlled studies were eligible for selection. Two independent reviewers assessed the risk of bias of controlled studies and extracted data. Meta‐analysis (using Mantel‐Haenszel's statistical method and random effect models) was performed when >2 RCTs were available that met our criteria. Evidence statements, including the certainty of evidence, were formulated according to GRADE.ResultsWe included a total of 29 studies, of which 16 were RCTs. A foot‐ankle exercise programme of 8–12 weeks duration for people at risk of foot ulceration results in: (a) no increase or decrease risk of foot ulceration or pre‐ulcerative lesion (Risk Ratio (RR): 0.56 (95% CI: 0.20–1.57)); (b) no increase or decrease risk of adverse events (RR: 1.04 (95% CI: 0.65–1.67)); (c) not increase or decrease barefoot peak plantar pressure during walking (Mean Difference (MD): −6.28 kPa (95% CI: −69.90–57.34)); (d) no increase or decrease health‐related quality of life (no meta‐analysis possible). Likely results in increases in ankle joint and first metatarsalphalangeal joint range of motion (MD: 1.49° (95% CI: −0.28–3.26)) may result in improvements in neuropathy signs and symptoms (MD: −1.42 (95% CI: −2.95‐0.12)), may result in a small increase in daily steps in some people (MD: 131 steps (95% CI: ‐492‐754)), and may not increase or decrease foot and ankle muscle strength and function (no meta‐analysis was possible).ConclusionsIn people at risk of foot ulceration, a foot‐ankle exercise programme of 8–12 weeks duration may not prevent or cause diabetes‐related foot ulceration. However, such a programme likely improves the ankle joint and first metatarsalphalangeal joint range of motion and neuropathy signs and symptoms. Further research is needed to strengthen the evidence base, and should also focus on the effects of specific components of foot‐ankle exercise programs.
Maternal provisioning of an obligate symbiont in a sponge
Authors: Carrier Tyler J. , Schmittmann Lara , Jung Sabrina , Pita Lucía , Hentschel Ute 
Published: May 2023

AbstractThe transmission of microbes from mother to offspring is an ancient, advantageous, and widespread feature of metazoan life history. Despite this, little is known about the quantitative strategies taken to maintain symbioses across generations. The quantity of maternal microbes that is provided to each offspring through vertical transmission could theoretically be stochastic (no trend), consistent (an optimal range is allocated), or provisioned (a trade‐off with fecundity). Examples currently come from animals that release free‐living eggs (oviparous) and suggest that offspring are provided a consistent quantity of symbionts. The quantity of maternal microbes that is vertically transmitted in other major reproductive strategies has yet to be assessed. We used the brooding (viviparous) spongeHalichondria paniceato test whether offspring receive quantitatively similar numbers of maternal microbes. We observed thatH. paniceahas a maternal pool of the obligate symbiontCandidatusHalichondribacter symbioticus and that this maternal pool is provisioned proportionally to reproductive output and allometrically by offspring size. This pattern was not observed for the total bacterial community. Experimental perturbation by antibiotics could not reduce the abundance ofCa.H. symbioticus in larvae, while the total bacterial community could be reduced without affecting the ability of larvae to undergo metamorphosis. A trade‐off between offspring size and number is, by definition, maternal provisioning and parallel differences inCa.H. symbioticus abundance would suggest that this obligate symbiont is also provisioned.
Exploring the Coordination Properties of Phosphonium‐Functionalized N‐Heterocyclic Carbenes Towards Gold
Authors: De Marco Riccardo , Giuso Valerio , Achard Thierry , Rancan Marzio , Baron Marco , Armelao Lidia , Mauro Matteo , Bellemin‐Laponnaz Stéphane , Tubaro Cristina 
Published: May 2023

AbstractGold(I) complexes with N‐heterocyclic carbene ligands functionalized with a pendant phosphonium moiety were synthesized by simple procedures. In particular, the simple addition of LiBr salt in the reaction media allows the formation of the NHC gold(I) mononuclear complexes, whilst in the absence of excess bromide ions the deprotonation of the methylene group in alpha position to the phosphonium group occurs, allowing the isolation of the dinuclear complexes with two C,C‐bridging NHC‐phosphonium ylide ligands. The complexes were characterized in solution with NMR spectroscopy and ESI‐MS spectrometry, as well as in the solid state by means of single crystal X‐ray diffraction analysis. Mononuclear gold(III) species were also isolated by Br2 oxidative addition to the mononuclear gold(I) species and fully characterized. Preliminary results of the biological effects on MCF7 cancer cells are also reported.
Synthesis and Structures of Ruthena‐octahydrotetraborane Complexes
Authors: Ahmad Asif , Saha Suvam , Zafar Mohammad , Cordier Marie , Ghosh Sundargopal 
Published: May 2023

AbstractThe reactivity ofκ2‐N,S‐chelated ruthenium borate complexes, [Ru(PPh3)(κ2‐N,S‐(NC7H4S2)Ru{κ3‐H,S,S′‐H2B (NC7H4S2)2}] (1 a) and [Ru(PPh3)(κ2‐N,S‐(NC5H4S){κ3‐H,S,S′‐H2B(NC5H4S)2}] (1 b) with monoboranes have been explored. The prolonged room temperature reaction of [Ru(PPh3){κ2‐N,S‐(NC7H4S2)}{κ3‐H,S,S′‐H2B(NC7H4S2)2}],1 awith an excess of [BH3 ⋅ THF] led to the formation of hydrogen‐rich complex,arachno‐[PPh3(κ2‐B3H8)Ru{κ3‐H,S,S′‐H2B(NC7H4S2)2] (2). In a similar fashion, the isomeric ruthenatetraborane complexes of [Ru(PPh3)(κ2‐N,S‐(B3H8){κ3‐H,S,S′‐H2B(NC5H4S)2}],4and5were isolated from the room temperature reaction of1 bwith [BH3 ⋅ THF]. In complex2, the borate ligand, [H2B(NC5H4S)2] and the PPh3occupy theendoandexosites of the butterfly‐shaped RuB3core, respectively. In contrast, the borate unit [H2B(NC5H4S)2] in4sits on theexoposition of the butterfly core, while the phosphine ligand occupies theendosite. Multinuclear spectroscopic analyses were done to characterize all new complexes and the structures were further confirmed by single‐crystal X‐ray diffraction analysis. Density functional theory (DFT) calculations were performed to probe into the bonding modes of these complexes.
Atypical “Masked” Frustrated Lewis Pair Character in a Geminal‐Linked Phosphine‐Borane
Authors: Dokken Hannah J. , Frenette Brandon L. , Ferguson Michael J. , Rivard Eric 
Published: May 2023

AbstractWe report the synthesis and reactivity of the geminal‐linked fluorene‐derived P/B frustrated Lewis pair (FLP) iPr2P(C13H8)BCy2 (1). Compound 1 displays anomalous behavior towards small molecules, acting as a “masked” FLP. This behavior stems from significant polarization of the B−C(fluorene) bond in 1, as identified by density functional theory (DFT) computations. We exploit this B−C bond polarity through reactions with PhPCl2, H3N ⋅ BH3, and iPrNH2, demonstrating P−Cl and N−H bond activation, respectively.
Commodity network and predictable returns
Authors: Xu Qi , Ye Yang 
Published: May 2023

AbstractWe investigate the lead–lag relation in the cross‐section of commodity returns. We estimate dynamic and directional networks for 32 commodities and then construct a new predictor termed commodity network momentum, exploring cross‐commodity information spillover. Network momentum positively and significantly predicts future commodity returns, controlling for existing commodity characteristics. Unlike previous lead–lag studies, the predictive relation is consistent with overreaction rather than underreaction. The relation is stronger for attention‐grabbing commodities and commodities with lottery‐like properties and with higher limits to arbitrage. Extrapolation from connected commodities contributes to this predictive relation. Overall, our paper highlights the role of information spillover in commodity return predictability.
Neonatal osteoblastic tumor with a novel PTBP1::FOSB fusion
Authors: Blackburn Patrick R. , Douglass David P. , Ramakrishnaiah Raghu H. , Montgomery Corey O. , Shi Zonggao , Wheeler David A. , Koo Selene C. 
Published: May 2023

AbstractCongenital/neonatal bone neoplasms are extremely rare. We present the case of a patient with a neonatal bone tumor of the fibula that had osteoblastic differentiation and a novel PTBP1::FOSB fusion. FOSB fusions are described in several different tumor types, including osteoid osteoma and osteoblastoma; however, these tumors typically present in the second or third decade of life, with case reports as young as 4 months of age. Our case expands the spectrum of congenital/neonatal bone lesions. The initial radiologic, histologic, and molecular findings supported the decision for close clinical follow‐up rather than more aggressive intervention. Since the time of diagnosis, this tumor has undergone radiologic regression without treatment.
Evaluation of apathy among institutionalized older persons: Its mediating role between cognitive functioning and lack of awareness
Authors: Farrié Audric Joël , Jacus Jean‐Pierre , Cuervo‐Lombard Christine Vanessa 
Published: May 2023

AbstractObjectivesThe main objective of this study was to determine the directions of the relationships between apathy, cognitive deficits and lack of awareness.MethodsOne hundred and twenty‐one older persons living in nursing homes, aged between 65 and 99 years old, participated in the study. Cognitive functioning, autonomy, depressive and anxious symptoms, general self‐efficacy, self‐esteem and apathy were evaluated through tests and questionnaires. Lack of awareness was calculated using the patient‐caregiver discrepancy method. The sample was divided into two groups (n1 = 60, n2 = 61) depending on cognitive functioning level (Dementia Rating Scale < median score: 120). We first explored the characteristics of each group. Then, we compared the mode of evaluation of apathy. Finally, we investigated the direction of relationships by applying mediation analyses.ResultsOlder persons in the low cognitive functioning group were less autonomous, had a lower cognitive functioning level, higher caregiver‐rated apathy and higher lack of awareness than the high cognitive functioning group (ps < 0.05). Evaluation differences were found only in the low cognition group. Caregiver‐rated apathy totally mediated the relationship between cognitive functioning (predictor) and lack of awareness (dependent variable) for the whole sample (90%) and for the low cognitive functioning group (100%).ConclusionsCognitive deficits should be taken into account when evaluating apathy. Interventions should combine cognition training and emotion intervention to reduce lack of awareness. Future research should develop a therapy dedicated to apathy among older persons without pathologies.
The role of long‐ and short‐run correlation networks in international portfolio selection
Authors: Li Mengting , Xu Qifa , Jiang Cuixia , Liu Yezheng 
Published: May 2023

AbstractBy considering the effect of long‐ and short‐run correlation (LS) networks, we propose an LS network‐augmented parametric portfolio selection model (LSNA‐PP). First, we combine the dynamic conditional correlation‐mixed data sampling (DCC‐MIDAS) model with the planar maximally filtered graph (PMFG) method to construct LS networks and extract network topological characteristics. Second, we design portfolio weights as a function of these topological characteristics to construct the LSNA‐PP model. Third, we apply the model to construct an international portfolio from 2010 to 2021. The empirical results illustrate the efficacy of the LSNA‐PP model in two ways. First, the LSNA‐PP model clarifies the economic interpretation of topological characteristics in portfolio selection, such as the positive effect of the long‐run correlation network and the negative effect of the short‐run correlation network on the weights. Second, the LSNA‐PP model performs well in terms of return expectations, risk diversification, and attractive risk‐adjusted returns, which are especially useful for stakeholders such as regulators, managers, and investors.
A precise and timely graph‐based approach to identify SARS Covid19 infection from medical imaging data using IsoCovNet
Authors: Bagwan Faraz , Pise Nitin 
Published: May 2023

AbstractMore than 100 million individuals have been infected by the COVID19 virus since 2019. Even if the vaccination procedure has already begun, it will take time to attain an adequate supply. There have been several efforts by computer scientists to filter COVID19 from CXR or CT scans due to the disease's extensive prevalence. These patients' CT and CXR scans are utilized to identify COVID19 using IsoCovNet, a Graph‐Isomorphic‐Network, that is, GIN‐based model for detecting COVID19. A GIN‐based design dictates that our suggested model only takes data in the form of graphs. At the outset, the input image undergoes a conversion into an unordered network, that is, a graph that considers only the links between elements rather than the entire image. This approach significantly reduces the model's processing time. We verified the effectiveness of our proposed IsoCovNet network by using four datasets, which consist of both x‐ray and CT‐scan images, from five standard sources that are publicly available on platforms like Kaggle and GitHub. The network achieved an accuracy of 99.51% on binary datasets and a higher accuracy of 99.84% on the multi‐classification task of detecting Covid19.
Monkeypox: Virology, laboratory diagnosis and therapeutic approach
Authors: Siami Haleh , Asghari Arghavan , Parsamanesh Negin 
Published: May 2023

AbstractMonkeypox infection outbreaks have been observed sporadically in Africa, usually as a result of interaction with wildlife reservoirs. The genomes of the new strain range in size from 184.7 to 198.0 kb and are identified with 143–214 open reading frames. Viral cores are rapidly carried on microtubules away from the cell's perimeter and deeper into the cytoplasm once the virus and cell membranes fuse. Depending on the kind of exposure, patients with monkeypox may experience a febrile prodrome 5–13 days after exposure, which frequently includes lymphadenopathy, malaise, headaches, and muscle aches. A different diagnostic approach is available for monkeypox, including histopathological analysis, electron microscopy, immunoassays, polymerase chain reaction, genome sequencing, microarrays, loop‐mediated isothermal amplification technology and CRISPR (i.e., “clustered regularly interspaced short palindromic repeats”). There are currently no particular, clinically effective treatments available for the monkeypox virus. An initial treatment is cidofovir. As a monophosphate nucleotide analog, cidofovir is transformed into an inhibitor of viral DNA polymerase by cellular kinases, which is analogous to cidofovir's function in inhibiting viral DNA synthesis. The European Medicine Agency and the Food and Drug Administration have both granted permission for IMVAMUNE, a replication‐deficient, attenuated third‐generation modified vaccinia Ankara vaccine, to be used for the prevention of smallpox and monkeypox in adults.
Intravoxel Incoherent Motion Diffusion‐Weighted MR Imaging and Venous Tumor Thrombus Consistency in Renal Cell Carcinoma
Authors: Zhao Jian , Wang Meifeng , Ding Xiaohui , Fu Yonggui , Peng Cheng , Kang Huanhuan , Guo Huiping , Bai Xu , Huang Qingbo , Zhou Shaopeng , Zhang Xiaojing , Liu Kan , Li Lin , Ye Huiyi , Zhang Xu , Ma Xin , Wang Haiyi 
Published: May 2023

BackgroundVenous tumor thrombus (VTT) consistency of renal cell carcinoma (RCC) is an important consideration in nephrectomy plus thrombectomy. However, evaluation of VTT consistency through preoperative MR imaging is lacking.PurposeTo evaluate VTT consistency of RCC through intravoxel incoherent motion‐diffusion weighted imaging (IVIM‐DWI) derived parameters (Dt, Dp, f, and ADC) and the apparent diffusion coefficient (ADC) value.Study TypeRetrospective.PopulationOne hundred and nineteen patients (aged 55.8 ± 11.5 years, 85 male) with histologically‐proven RCC and VTT who underwent radical resection.Field Strength/Sequences3.0‐T; two‐dimensional single‐shot diffusion‐weighted echo planar imaging sequence at 9 b‐values (0–800 s/mm2).AssessmentIVIM parameters and ADC values of the primary tumor and the VTT were calculated. The VTT consistency (friable vs. solid) was determined through intraoperative findings of two urologists. The accuracy of VTT consistency classification based on the individual IVIM parameters of primary tumors and of VTT, and based on models combining parameters, was assessed. Type of operation, intra‐operative blood loss, and operation length were recorded.Statistical TestsShapiro–Wilk test; Mann–Whitney U test; Student's t‐test; Chi‐square test; Receiver operating characteristic (ROC) analysis. Statistical significance level was P < 0.05.ResultsOf the enrolled 119 patients, 33 patients (27.7%) had friable VTT. Patients with friable VTT were significantly more likely to experience open surgery, have significantly more intraoperative blood loss, and significantly longer operative duration. The area under the ROC curve (AUC) values of Dt of the primary tumor and VTT in classifying VTT consistency were 0.758 (95% CI 0.671–0.832) and 0.712 (95% CI 0.622–0.792), respectively. The AUC value of the model combining Dp and Dt of VTT was 0.800 (95% CI 0.717–0.868). Furthermore, the AUC of the model combining Dp and Dt of VTT and Dt of the primary tumor was 0.886 (95% CI 0.814–0.937).ConclusionIVIM‐derived parameters had the potential to predict VTT consistency of RCC.Evidence Level: 3Technical Efficacy: Stage 2
Clinical validation of novel dried blood spot based collecting device using serum separation for measuring SARS‐CoV‐2 antibodies
Authors: Schuurmans Stekhoven Sophie Jolien , Winkel Kirsten Gerdien te , Souverein Dennis , Sondermeijer Brigitte Marlene , van Houten Marianne A. , Euser Sjoerd M. , van Lelyveld Steven Ferdinand Lodewijk 
Published: May 2023

AbstractAccurate surveillance of coronavirus disease 2019 (COVID‐19) incidence includes large‐scale antibody testing of the population. Current testing methods require collection of venous blood samples by a healthcare worker, or dried blood spot (DBS) collection using finger prick, however this might have some logistic and processing limitations. We investigated the performance of the Ser‐Col device for detecting severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) antibodies using a finger prick: DBS‐like collection system that includes a lateral flow paper for serum separation and allows for automated large scale analysis. For this prospective study, adult patients with moderate to severe COVID‐19 were included 6 weeks post‐symptom onset. Healthy, adult volunteers were included as a negative control group. Venous blood and capillary blood using the Ser‐Col device were collected and the Wantai SARS‐CoV‐2 total antibody ELISA was performed on all samples. We included 50 subjects in the study population and 49 in the control group. Results obtained with venous blood versus Ser‐Col capillary blood showed 100% sensitivity (95% CI: 0.93−1.00) and 100% specificity (95% CI: 0.93−1.00). Our study shows the feasibility of SARS‐CoV‐2 total antibody screening using a standardized DBS technique with semiautomated processing for large scale analysis.
VARMA model parameterization using MLLE approach for intraday wind power forecasting application
Authors: Vijayvargia Archita , Sharma Kailash Chand , Bhakar Rohit 
Published: May 2023

AbstractAccurate intraday wind power forecasting (WPF) is required by system operators to mitigate challenges arising from small‐scale grid integration of intermittent wind power. This low‐level integration of wind energy into the system urges quality deterministic forecast. Multivariate statistical models considering spatiotemporal correlations are commonly used for such WPF. However, prudent parameterization is a necessity to improve deterministic forecasts even in smaller datasets. This article proposes a computationally efficient vector autoregressive moving average (VARMA) based intraday WPF model that uses the novel maximum log‐likelihood estimation (MLLE) approach to estimate the best‐fit model parameters. MLLE approach reduces the spatiotemporal fitting error by approximately 15% with computational time deduction by more than 25%. Furthermore, an advanced accuracy in parameter estimation (AIPE) technique supports the MLLE approach to obtain the optimal training window length for computing distribution parameters with narrow confidence intervals. Proposed centralized forecast model is implemented on a group of Wind Farms (WFs) in SE Australia. Pre‐processing of wind power generation data is ensured using the Yeo–Johnson transformation and stationarity concept. Proposed model is accurate and computationally efficient as compared to benchmark models in terms of accuracy and computational time. An appreciated forecast quality is achieved using the proposed model having only 0.20 MW and 0.29 MW mean normalized RMSE for 3 and 10 WFs studies, respectively. Possible applicability of the proposed model includes an overall improvement in intraday decision‐making of wind energy producers and system operators.