bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of maternal serum albumin at term to determine its correlation with birth weight of babies
Authors: Akter Syma , Tabassum Erina , Luna Sharmin Akter , Khatun Salma , Biswas Mitra , Begum Beauty 
Published: July 2023

Background: Serum albumin is a vital laboratory indicator of nutrition status. Fetal weight depends upon the nutritional status of mothers. Indeed, the serum albumin status at term may help to assume the fetal weight. We do have not enough research-based data regarding this issue. The aim of this study was to estimate maternal serum albumin at term and to observe its correlation with the birth weight of babies.
Methods: This cross-sectional analytical study was done at department of gynaecology and obstetrics, Sir Salimullah medical college and Mitford hospital, Dhaka, Bangladesh from July 2019 to June 2020. A total of 96 mother-baby pairs were selected using purposive sampling method. Women with single full-term pregnancy based on fundal height on Naegele’s rule irrespective of any mode of delivery was included in this study. Mothers with normal albumin levels (3.6-5.2 gm/dl) were defined as group A and mothers with low albumin levels (<3.6 gm/dl) in group B. Statistical analyses of the results were obtained by using window-based computer software devised with SPSS-22.
Results: In analyzing the maternal serum albumin level, we observed that majority of the participants were with normal albumin levels which were 81% and the rest 19% of patients were low albumin levels. In this study, it was observed that more than half (56.4%) of babies were male in group A and 9 (50.0%) in group B. The majority (94.9%) of babies’ birth weights were ≥2.5 kg in group A and 4 (22.0%) in group B. The difference of birth weight was statistically significant (p<0.05) between the two groups. Maternal serum albumin was significantly associated with birth weight of babies in multivariate analysis. But negatively correlated with newborn birth weight which is statistically significant.
Conclusions: Maternal albumin was observed to be directly proportional to the birth weight of babies.
Management as a science and art
Authors: Mrs.Rohini Gaikwad Dr.Vinaykumar Nimbalkar, Mr.Mithun Jadhav 
Published: July 2023

The management itself is the iterative process which revolves under itself. This is infinite time process where each iteration gives birth to new system or new concept. One has to stir so much, so that one can feel the destination has been achieved. But the rigorous efforts are to be poured to achieve maximum gain through maximum revenue and with great efficiency. To have maximum efficiency the execution of system and time rate of each execution of every module or segment must be efficient more than 100% and it is the high level synchronizing process amongst all steps in the final product making in entire process to execute and to trigger at perfect time to get best possible results
Evaluation of Pediatric Immune Thrombocytopenia (ITP) Cases and Risk Factors for Chronic ITP - Single Center Experience
Authors: ERDOĞAN Selçuk , KASAP Tuba , TAKÇI Şahin , GÜL Ali , SÖNMEZGÖZ Ergün , KARAASLAN Erhan , GÜMÜŞER Rüveyda , DEMİR Osman 
Published: July 2023

Aim: Immune thrombocytopenia (ITP) is the most common acquired bleeding disorder in childhood. The study aimed to assess the demographic and clinical characteristics, and treatment responses and to evaluate their effects on chronicity in pediatric ITP cases.
Material and Methods: Primary ITP patients aged 1 month to 18 years, who were diagnosed and followed up in the Pediatrics Clinic of Tokat Gaziosmanpaşa University Hospital between January 2010 and December 2018, were retrospectively analyzed.
Results: Thirty-eight patients with a diagnosis of primary ITP were included in the study. The mean age of the patients was 94.3±53.4 (14-199) months. The female/male ratio was 1. Twenty (57.1%) patients had acute ITP, and 15 (42.9%) patients had chronic ITP. There was no significant difference between the acute ITP group and the chronic ITP group in demographic, clinical features, laboratory findings, and treatment responses. In the first 12 months, the number of admissions with a platelet count of
Clinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis infected with SARS-CoV-2 Omicron subvariant BA.5.2
Authors: Ha Xiaowen , Zhao Zhigang , Zhao Tiantian , muhetaer gulimire , Wang Xiaoyu , Bao Aihong , Duan Yanya , Zhuang Jing , Song Xue , Zhou Yipeng , Zhang Qingqing , Wu Jianhua , Fan Min , Zhang Li , Tian Xuefei , Jiang Hong 
Published: July 2023

Abstract
To analyze the clinical characteristics and outcomes of unvaccinated adult patients on maintenance hemodialysis infected with SARS-CoV-2 Omicron subvariant BA.5.2.The clinical data of 427 maintenance hemodialysis patients infected with SARS-CoV-2 Omicron subvariant BA.5.2 in our hospital were retrospectively collected. The patients were grouped according to the severity of the disease and compared. The clinical outcome and two-month follow-up were analyzed.These results suggest that CRP level, procalcitonin level, and bicarbonate concentration are related to the severity of disease caused by SARS-CoV-2 omicron BA.5.2 infection in unimmunized MHD patients. In addition, the co-bacterial infection may be an important cause of severe illness. Therefore, strengthen the treatment of critically ill patients, and actively and effectively control infection and secondary infection; Effective vaccination is the key to improving clinical outcomes to prevent the conversion of ordinary patients to severe and critical cases. Fever, age, ORF1ab gene value, and arterial oxygen partial pressure may be independent risk factors for disease severity in COVID-19 patients.
Molecular Bonding Regulated Defect Passivation for Modulating Efficiency and Stability of Methylammonium Free Inverted Perovskite Solar Cells
Authors: Shirai yasuhiro , Yanagida Masatoshi , Lyalin Andrey , Taketsugu Tetsuya , Miyano Kenjiro , KHADKA DHRUBA 
Published: July 2023

Abstract
Molecular passivation is a prominent approach for improving the power conversion efficiency and operation stability of perovskite solar cells. Herein, diammonium iodide functional molecules with an aryl or alkyl core are introduced on 3D-perovskite, and its interfacial passivation effect is explored. It showed that piperazine dihydriodide (PZDI) with alkyl core-electron rich -NH terminal is propitious to mitigate surface and bulk defects and modify surface chemistry or interfacial energy band leading to increase carrier extraction. Benefiting from superior PZDI passivation, the device efficiency has been scaled to 23.17% (area ~1 cm2) with superior operational device stability. We also achieved a certified efficiency of ~21.50% (area ~1.024 cm2). The theoretical calculation suggests that PZDI entangles onto the film’s surface with -NH2I anchor, and reinforces the adhesion. Device analysis corroborates that a stronger bonding interaction attenuates the defect densities in the perovskite film and suppresses ion migration, which is supported by the first-principle calculations. This work demonstrated that the bifunctional molecules with stronger surface adsorption play a crucial role in triggering defect mitigation, which paves the way for the design of bonding-regulated molecular passivation for enhancing device performance and stability.
Angiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya disease
Authors: Shirozu Noritoshi , Ohgidani Masahiro , Hata Nobuhiro , Tanaka Shunya , Inamine Shogo , Sagata Noriaki , Kimura Tetsuaki , Inoue Ituro , Arimura Koichi , Nakamizo Akira , Nishimura Ataru , Maehara Naoki , Takagishi Soh , Iwaki Katsuma , Nakao Tomohiro , Masuda Keiji , Sakai Yasunari , Mizoguchi Masahiro , Yoshimoto Koji , Kato Takahiro A. 
Published: July 2023

Abstract
Angiogenic factors associated with Moyamoya disease (MMD) are overexpressed in M2 polarized microglia in ischemic stroke, suggesting that microglia may be involved in the pathophysiology of MMD; however, existing approaches are not applicable to explore this hypothesis. Herein we applied blood induced microglial-like (iMG) cells.
We recruited 25 adult patients with MMD and 24 healthy volunteers. Patients with MMD were subdivided into progressive (N = 7) or stable (N = 18) group whether novel symptoms or radiographic advancement of Suzuki stage within 1 year was observed or not. We produced 3 types of iMG cells; resting, M1-, and M2-induced cells from monocytes, then RNA sequencing followed by GO and KEGG pathway enrichment analysis and qPCR assay were performed.
RNA sequencing of M2-induced iMG cells revealed that 600 genes were significantly upregulated (338) or downregulated (262) in patients with MMD. Inflammation and immune-related factors and angiogenesis-related factors were specifically associated with MMD in GO analysis. qPCR for MMP9, VEGFA, and TGFB1 expression validated these findings. This study is the first to demonstrate that M2 microglia are involved in the angiogenic process of MMD. The iMG technique provides a promising approach to explore the bioactivity of microglia in cerebrovascular diseases.
Mitochondrial Magnesium is the cationic rheostat for MCU-mediated mitochondrial Ca2+ uptake
Authors: Shanmughapriya Santhanam , Ponnusamy Thiruvelselvan , Velusamy Prema , Kumar Amrendra , Morris Daniel , Zhang Xueqian , Ning Gang , Klinger Marianne , Copper Jean , Rajan Sudarsan , Cheung Joseph , Kalimuthusamy Natarajaseenivasan , Mnatsakanyan Nelli 
Published: July 2023

Abstract
Calcium (Ca2+) uptake by mitochondria is essential in regulating bioenergetics, cell death, and cytosolic Ca2+ transients. Mitochondrial Calcium Uniporter (MCU) mediates the mitochondrial Ca2+ uptake. MCU is a hetero-oligomeric complex with a pore-forming component and accessory proteins required for channel activity. Though MCU regulation by MICUs is unequivocally established, there needs to be more knowledge of whether divalent cations regulate MCU. Here we set out to understand the mitochondrial matrix Mg2+-dependent regulation of MCU activity. We showed Mrs2 as the authentic mammalian mitochondrial Mg2+ channel using the planar lipid bilayer recordings. Using a liver-specific Mrs2 KO mouse model, we showed that decreased matrix [Mg2+] is associated with increased MCU activity and matrix Ca2+ overload. The disruption of Mg2+-dependent MCU regulation significantly prompted mitochondrial permeability transition pore opening-mediated cell death during tissue IR injury. Our findings support a critical role for mMg2+ in regulating MCU activity and attenuating mCa2+ overload.
Associations between 47 anthropometric markers derived from a body scanner and relative fat-free mass in a population-based study
Authors: Dietzmann Maximilian , Radke Dörte , Markus Marcello RP , Wiese Mats , Völzke Henry , Felix Stephan B. , Dörr Marcus , Bahls Martin , Ittermann Till 
Published: July 2023

Abstract

Background
Low relative fat free mass (FFM) is associated with an increased risk of chronic diseases and mortality. However, FFM assessment in clinical routine is time consuming and currently not being done.
Objective
Our aim was to identify easily accessible anthropometric markers assessed by a 3D optical body-scanner, which showed strong associations with FFM derived by either bioelectrical impedance analysis (BIA) or air displacement plethysmography (ADP).
Material And Methods
We analyzed data of 1,593 individuals (784 women; 49.2%, age range 28–88 years) enrolled in the population-based Study of Health in Pomerania (SHIP-TREND 1). Forty-seven anthropometric markers were derived from a body scanner. FFM was assessed by BIA and ADP. Anthropometric measurements were associated with FFM by sex-stratified linear regression models adjusted for body height and age. Anthropometric markers were ranked according to the coefficient of determination (R2) derived from these regression models.
Results
Circumferences of high hip, belly, middle hip, waist and high waist showed the strongest inverse associations with FFM. These relations were stronger in females than in males. Associations of anthropometric markers with FFM measured by ADP were greater compared to FFM assessment by BIA. Manually measured waist and hip circumference showed slightly weaker associations with the FFM compared to automated measurements.
Conclusion
Single anthropometric body scanner measures were more strongly associated with FFM assessed by ADP compared to FFM determined by BIA. Body scanner circumferences showed stronger associations with FFM than manual measurements. The detected anthropometrics could be helpful in assessing FFM in clinical routine.
Eco-friendly and practical plastic food-packaging alternatives of all-biomass-derived nanocomposite films
Authors: Chi Zhe , Ding Yuanyuan , Zhang Peng , Zhang Fenglong , Zhong Bocun , Yang Tenglin , Ding Xiang , Liu Chenguang 
Published: July 2023

Abstract
Approximately 60% of plastic pollution originates from the food and beverage packaging. Complete degradation of the bio-based plastic packaging presently available, relies on garbage sorting, recycling, and composting. Herein, we showcase that naturally-degradable bioplastics as food packaging alternatives can be accomplished with all-biomass nanocomposite encompassing pullulan, nanocellulose (NC) and/or hydrophobic lignin (HBL) using simple approaches. NC and HBL were derived from corn stalk using a recyclable eco-friendly deep eutectic solvent (DES). Optimal dispersion of NC in pullulan through high-pressure homogenization produced a pullulan-NC (PNC) bio-nanocomposite film with mechanical strength enhanced to 76.6 ± 1.9 MPa. Single PNC film could serve as food inner-packaging; while it collaborated with kraft paper wrapping to compensate its inadequate water resistance, performing as packaging for dry powders, biscuits, and oil. Remarkably, a sandwich-like film, created by hot-pressing two outer layers of HBL-NC (LNC) films and one PNC film layer, exhibited desirable mechanical strength and water resistance. Varying the number of LNC and PNC layers achieved diverse composite films as food outer-packaging, including preserving and shopping bags, disposable cups and straws. Significantly, all these films are biosafe and readily degraded in nature without counting on composting or recycling, underlining their prospects in future industrialization and sustainability.
Developing Public Health Surveillance Dashboards: A Scoping Review on the Design Principles
Authors: Rabiei Reza , Bastani Peivand , Ahmadi Hossein , Dehghan Shirin , Almasi Sohrab 
Published: July 2023

Abstract
Background
Public health dashboards facilitate the monitoring and prediction of disease outbreaks by continuously monitoring the health status of the community. This study aimed to identify design principles and determinants for developing public health surveillance dashboards.
Methodology
This scoping review is based on Arksey and O'Malley's framework as included in JBI guidance. Four databases were used to review and present the proposed principles of designing public health dashboards: IEEE, PubMed, Web of Science, and Scopus. We considered articles published between 2010 and 2022. The final search of articles was done on November 30, 2022. Only articles in English language were included. Qualitative synthesis and trend analysis was conducted.
Results
Findings from sixty-seven articles out of 543 retrieved articles which were eligible for analysis, indicate that most of the dashboards designed from 2020 onwards were at the national level for managing and monitoring COVID-19. Design principles for the public health dashboard were presented in five groups, i.e., considering aim and target users, appropriate content, interface, data analysis and presentation types, and infrastructure.
Conclusion
Effective and efficient use of dashboards in public health surveillance requires putting the design principles into practice to improve the functionality of these systems in monitoring and decision making. Taking requirements of users into account, developing a robust infrastructure for improving data accessibility, developing and applying Key Performance Indicators (KPIs) for data processing and reporting purposes, and designing interactive and intuitive interfaces are key for successful design and development.
Group-to-group Recommendation with Neural Graph Matching
Authors: Wang Chunchen , Wang Wei , Yang Cheng , Shi Chuan , Xie Ruobing , Lu Yuanfu , Yang Haili , Zhang Xu 
Published: July 2023

Abstract
Nowadays, with the development of recommender systems, an emerging recommendation scenario called group-to-group recommendation has played a vital role in information acquisition for users. The new recommendation scenario seeks to recommend a group of related items to users with similar interests.
To some extent, it alleviates the problem of point-to-point recommendations getting trapped in an information cocoon due to an over-reliance on user behaviors. For the new recommendation scenario, the existing recommendation methods cannot model the complex interactions between user groups and item groups, thus affecting the accuracy of the group-to-group recommendation.
In this paper, we propose a group-to-group recommendation method, which abstracts user groups and item groups into graphs and calculates the similarity between two graphs based on graph matching, dubbed as GMRec.
Specifically, we construct the graph of user groups and item groups and then calculate the graph similarity scores between user groups and item groups from two perspectives of feature matching and structure matching.
Experimental results show that our model achieves higher accuracy than state-of-the-art models on three industrial datasets with different group sizes, with a maximum improvement of 8.2\%.
Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer’s disease
Authors: Tallon Carolyn , Bell Benjamin J , Malvankar Medhinee M , Deme Pragney , Nogueras-Ortiz Carlos , Eren Erden , Thomas Ajit G , Hollinger Kristen R , Pal Arindom , Mustapic Maja , Huang Meixiang , Coleman Kaleem , Joe Tawnjerae R , Rais Rana , Haughey Norman J , Kapogiannis Dimitrios , Slusher Barbara S 
Published: July 2023

Abstract
Background Cognitive decline in Alzheimer’s disease (AD) is associated with prion-like tau propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EV). EV biogenesis is triggered by ceramide enrichment at the plasma membrane from neutral sphingomyelinase2(nSMase2)-mediated cleavage of sphingomyelin. We report, for the first time, that tau expression triggers an elevation in brain ceramides and nSMase2 activity.Methods To determine the therapeutic benefit of inhibiting this elevation, we evaluated the efficacy of PDDC, the first potent, selective, orally bioavailable, and brain-penetrable nSMase2 inhibitor, in the PS19 tau transgenic AD murine model. Changes in brain ceramide and sphingomyelin levels, Tau content, histopathology, and nSMase2 target engagement were monitored, as well as changes in the number of brain-derived EVs in plasma and their Tau content. Additionally, we evaluated the ability of PDDC to impede tau propagation in a murine model where an adeno-associated virus(AAV) encoding for P301L/S320F double mutant human tau was stereotaxically-injected unilaterally into the hippocampus and the contralateral transfer to the dentate gyrus was monitored.Results Similar to human AD, PS19 mice exhibited increased brain ceramides and nSMase2 activity; both were completely normalized by PDDC treatment. PS19 mice exhibited elevated tau immunostaining, thinning of hippocampal neuronal cell layers, increased mossy fiber synaptophysin immunostaining, and glial activation, all pathologic features of human AD. PDDC treatment significantly attenuated these aberrant changes. Mouse plasma isolated from PDDC-treated PS19 mice exhibited reduced levels of neuron- and microglia-derived EVs, the former carrying lower phosphorylated Tau(pTau) levels, compared to untreated mice. In the AAV tau propagation model, PDDC normalized the tau-induced increase in brain ceramides and significantly decreased tau spreading to the contralateral side.Conclusions PDDC is a first-in-class therapeutic candidate that normalizes elevated brain ceramides and nSMase2 activity leading to the slowing of tau spread in AD mice.
Differences in the absolute muscle strength and power of children and adolescents with overweight or obesity. A systematic review
Authors: ALANIZ-ARCOS José Luis , ORTIZ-CORNEJO Ma. Elena , LARIOS-TINOCO José Omar , KLÜNDER-KLÜNDER Miguel , Physical Karla VIDAL-MITZI. , GUTIÉRREZ-CAMACHO Claudia 
Published: July 2023

Abstract
This study aimed to describe absolute muscle strength and power in children and adolescents with obesity, overweight and normal weight, and the assessment tests and tools used. We retrieved observational studies from MEDLINE (PubMed), TripDataBase, Epistemonikos, EBSCO essentials, NICE, SCOPUS, and LILACs up to February 2023. In addition, we recovered data from studies with at least three comparison groups (obesity, overweight, normal weight) and with a description of the absolute muscle strength and power and the assessment tests and instruments used. The methodologic quality of the studies was assessed with the Joanna Briggs checklist, and the review was carried out using the PRISMA 2020 methodology. Eleven studies with 13, 451 participants aged 6 to 18 were included; upper limb absolute muscle strength was higher in overweight and obese compared to normal weight, but not when loading their body weight. In addition, lower limb absolute muscle strength was significantly lower in obese participants than in normal weight, regardless of age and gender. The most used tools to measure the absolute muscle strength of the upper limbs were the grip dynamometers and push-up exercises. In contrast, different jump tests were used to measure the power of the lower limbs. There are great differences in muscle strength and power between overweight or obese children and adolescents and those with normal weight. Therefore, it is recommended to use validated tests, preferably that assess strength through the load of the patient's body weight, either of the upper or lower limbs, for greater evaluation objectivity that facilitates the management of these children and adolescents.