bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D Block Modelling of the Sin Quyen IOCG Deposit, North Vietnam
Authors: Duong Van Hao , Nguyen Chau Dinh , Klityński Wojciech , Zygo Władysław , Nowak Jakub 
Published: August 2023

The IOCG Sin Quyen deposit is located in the Red River shear zone of North Vietnam. The ore bodies are known as hydrothermal veins and are hosted in Proterozoic metapelite. A block modelling approach was used to build a 3D model of the ore bodies. An analysis was carried out on SurferR 11 computer software using the archival data recorded from several dozen boreholes distributed within the study area, as well as data obtained from the mineral and chemical analysis of 50 samples collected recently in the deposit. The ore bodies generally trend in a NW-SE direction with an average azimuth of 107° and a dip of around 70°. Cu content in the ore bodies is inhomogeneous. In the bed extension direction, the exponential correlation of Cu concentration in ore bodies is recognized within 2,500 m, while in the direction perpendicular to the bed strike, the exponential dependence is observed at 500 m of distance. The high-grade mineralisation of copper within the ore bodies is often at the altitude interval from ∼100 m to ∼150 m above sea level (asl). These bodies are also rich in uranium and gold-bearing minerals. The total resources of Cu, U and Ag were estimated and amounted to 361,000; 12.7 and 11.87 tonnes respectively. The model indicates the downward extension of some ore bodies to below 300 m beneath the ground surface.
Integrative models of histopathological images and multi-omics data predict prognosis in endometrial carcinoma
Authors: Li Yueyi , Du Peixin , Zeng Hao , Wei Yuhao , Fu Haoxuan , Zhong Xi , Ma Xuelei 
Published: August 2023

Objective
This study aimed to predict the molecular features of endometrial carcinoma (EC) and the overall survival (OS) of EC patients using histopathological imaging.

Methods
The patients from The Cancer Genome Atlas (TCGA) were separated into the training set (n = 215) and test set (n = 214) in proportion of 1:1. By analyzing quantitative histological image features and setting up random forest model verified by cross-validation, we constructed prognostic models for OS. The model performance is evaluated with the time-dependent receiver operating characteristics (AUC) over the test set.

Results
Prognostic models based on histopathological imaging features (HIF) predicted OS in the test set (5-year AUC = 0.803). The performance of combining histopathology and omics transcends that of genomics, transcriptomics, or proteomics alone. Additionally, multi-dimensional omics data, including HIF, genomics, transcriptomics, and proteomics, attained the largest AUCs of 0.866, 0.869, and 0.856 at years 1, 3, and 5, respectively, showcasing the highest discrepancy in survival (HR = 18.347, 95% CI [11.09–25.65], p < 0.001).

Conclusions
The results of this experiment indicated that the complementary features of HIF could improve the prognostic performance of EC patients. Moreover, the integration of HIF and multi-dimensional omics data might ameliorate survival prediction and risk stratification in clinical practice.
Condições Higiênico-Sanitárias em uma Fábrica de Farinha de Mandioca no município de Castanhal-PA avaliação e recomendações
Authors: E Oliveira Jose Moises de Oliveira , Santos Bueno Roger da Silva , De Lima Suely Cristina Gomes 
Published: August 2023

No beneficiamento da mandioca, são identificados desafios como instalações em péssimo estado de conservação e falta de aplicação de medidas higiênico-sanitárias. Este trabalho teve como objetivo avaliar o processo produtivo da farinha de mandioca em uma agroindústria localizada na zona rural de Castanhal-PA, e propor melhorias de acordo com as Boas Práticas de Fabricação (BPF). Para isso, foi realizado um checklist de BPF, que possibilitou a avaliação sanitária por meio do cálculo da porcentagem de conformidade. Com base nessa análise, a indústria foi classificada no grupo 3, apresentando 50,43% de conformidade, com índice mais baixo relacionado à documentação. Também foi aplicado um questionário aos colaboradores para avaliar o conhecimento deles sobre as BPF. Com base nesses resultados, um curso foi ministrado, no qual foi utilizado um folder infográfico que abordava os principais pontos de dúvida identificados no questionário. Além disso, foi elaborado um plano de ação contendo recomendações de melhorias para a agroindústria, com foco principalmente na infraestrutura do estabelecimento, visando evitar contaminações cruzadas. A implementação das medidas propostas têm como objetivo a melhoria das condições higiênico-sanitárias na fabricação da farinha, garantindo um produto seguro para o consumidor.
Effect of Different Herbicidal Weed Management on Yield and Economic of Ragi
Authors: Kumar Harendra , Tiwari Nitish , Savu Rama Mohan , Langangmeilu Golmei , Chandrakala  
Published: August 2023

The present experiment was carried on the performance of ragi at the Instructional cum Research Farm, Indira Gandhi Krishi Vishwavidyalaya, Raipur, Chhattisgarh during Kharif seasons 2021 and 2022 The field experiment was laid out of ragi (Indira ragi 1) was growing variety for test crop in Randomized block design (RBD) with 10 treatment and 3 replications. The crop was sown manually on seedcum fertilizers 1 July 2021 and 2 July 2022 after the onset of monsoon. The result of the experiment revealed that, different weed management practices on seed yield, straw yield, harvest index % and economics of different herbicide application of ragi reveals that T9: Green manuring up to 40 DAS required highest cost of cultivation (Mean viz., 39676Rs. ha-1) than hand weeding twice 20 and 40 DAS (Mean viz., 34876Rs. ha-1) and lowest cost of cultivation in control (Mean viz., 22876Rs. ha-1). Gross return, net return and B: C ratio was significantly higher under (T5) Pyrazosulfuron ethyl 10 % 20 g/ha (PE) fb Chlorimuronethyl 10 % + Metsulfuron methyl 10 % 4 g/ha (PoE). Seed and straw yield of finger millet (Mean viz., 2719 and 8167 kg ha-1 and 24.98%), Gross return, net return and B: C ratio (Mean viz., 94573, 68950Rs. ha-1 and 3.69) while minimum was recorded under T10: control during both years and on mean value.
Supplemental Nutrition Assistance Program Emergency Allotments and Food Security, Hospitalizations, and Hospital Capacity
Authors: Lavallee Matthew , Galea Sandro , Abuelezam Nadia N. 
Published: August 2023

ImportanceUnderstanding how social policies shape health is a national priority, especially in the context of the COVID-19 pandemic.ObjectiveTo understand the association between politically motivated changes to Nebraska’s Supplemental Nutrition Assistance Program (SNAP) policy and public health measures during the COVID-19 pandemic.Design, Setting, and ParticipantsThis cross-sectional study used synthetic control methods to estimate the association of Nebraska’s decision to reject emergency allotments for the SNAP with food security and hospital capacity indicators. A counterfactual for Nebraska was created by weighting data from the rest of the US. State-level changes in Nebraska between March 2020 and March 2021 were included. Data were acquired from the Census Bureau’s Household Pulse Survey on individual food security and mental health indicators and from the US Centers for Disease Control and Prevention on hospital-level capacity indicators. Data analysis occurred between October 2022 and June 2023.InterventionThe rejection of additional SNAP funds for low-income households in Nebraska from August to November 2020.Main Outcomes and MeasuresFood insecurity and inpatient bed use indicators (ie, inpatient beds filled, inpatient beds filled by patients with COVID-19, and inpatients with COVID-19).ResultsThe survey data of 1 591 006 respondents from May 2020 to November 2020 was analyzed, and 24 869 (1.56%) lived in Nebraska. Nebraska’s population was composed of proportionally more White individuals (mean [SD], 88.70% [0.29%] vs 78.28% [0.26%]; P &amp;lt; .001), fewer individuals who made more than $200 000 in 2019 (4.20% [0.45%] vs 5.22% [0.12%]; P &amp;lt; .001), and more households sized 1 to 3 (63.41% [2.29%] vs 61.13% [1.10%); P = .03) compared with other states. Nebraska’s rejection of additional funding for SNAP recipients was associated with increases in food insecurity (raw mean [SD] difference 1.61% [1.30%]; relative difference, 19.63%; P = .02), percentage of inpatient beds filled by patients with COVID-19 (raw mean [SD] difference, 0.19% [1.55%]; relative difference, 3.90%; P = .02), and percentage of inpatient beds filled (raw mean [SD] difference, 2.35% [1.82%]; relative difference, 4.10%; P = .02).Conclusions and RelevanceIn this cross-sectional study, the association between social policy, food security, health, and public health resources was examined, and the rejection of emergency allotments in Nebraska was associated with increased food insecurity. Additionally, this intervention was associated with an increased rate of hospitalizations for COVID-19 and non–COVID-19 causes.
Four‐Arm Polymer‐Guided Formation of Curcumin‐Loaded Flower‐Like Porous Microspheres as Injectable Cell Carriers for Diabetic Wound Healing
Authors: Yuan Xiaohuan , Yang Wei , Fu Yingying , Tao Ziwei , Xiao Lan , Zheng Qinzhou , Wu Dan , Zhang Mengya , Li Luxin , Lu Zhengmao , Wu Yan , Gao Jie , Li Yulin 
Published: August 2023

AbstractStem cell injection is an effective approach for treating diabetic wounds; however, shear stress during injections can negatively affect their stemness and cell growth. Cell‐laden porous microspheres can provide shelter for bone mesenchymal stem cells (BMSC). Herein, curcumin‐loaded flower‐like porous microspheres (CFPM) are designed by combining phase inversion emulsification with thermally induced phase separation‐guided four‐arm poly (l‐lactic acid) (B‐PLLA). Notably, the CFPM shows a well‐defined surface topography and inner structure, ensuring a high surface area to enable the incorporation and delivery of a large amount of ‐BMSC and curcumin. The BMSC‐carrying CFPM (BMSC@CFPM) maintains the proliferation, retention, and stemness of ‐BMSCs, which, in combination with their sustainable curcumin release, facilitates the endogenous production of growth/proangiogenic factors and offers a local anti‐inflammatory function. An in vivo bioluminescence assay demonstrates that BMSC@CFPM can significantly increase the retention and survival of BMSC in wound sites. Accordingly, BMSC@CFPM, with no significant systemic toxicity, could significantly accelerate diabetic wound healing by promoting angiogenesis, collagen reconstruction, and M2 macrophage polarization. RNA sequencing further unveils the mechanisms by which BMSC@CFPM promotes diabetic wound healing by increasing ‐growth factors and enhancing angiogenesis through the JAK/STAT pathway. Overall, BMSC@CFPM represents a potential therapeutic tool for diabetic wound healing.
Oxidized Low‐Density Lipoprotein (Ox‐LDL)‐Triggered Double‐Lock Probe for Spatiotemporal Lipoprotein Oxidation and Atherosclerotic Plaque Imaging
Authors: Zhi Xu , Sun Yufen , Cai Fangjian , Wang Sisi , Gao Hu , Wu Fan , Zhang Lei , Shen Zhen 
Published: August 2023

AbstractLow‐density lipoprotein (LDL), especially oxidative modified LDL (Ox‐LDL), is the key risk factor for plaque accumulation and the development of cardiovascular disease. Herein, a highly specific Ox‐LDL‐triggered fluorogenic‐colorimetric probe Pro‐P1 is developed for visualizing the oxidation and aggregation progress of lipoproteins and plaque. A series of green fluorescent protein chromophores with modified donor‐acceptor structures, containing carbazole as an electron donor and various substituents including pyridine‐vinyl (P1), phenol‐vinyl (P2), N, N‐dimethylaniline‐vinyl (P3), and thiophene‐vinyl (P4), have been synthesized and evaluated. Emission spectroscopy and theoretical calculations of P1–P4 indicate that P1 shows enhanced green fluorescence (λem = 560 nm) by inhibiting its twisted intramolecular charge transfer in the presence of Ox‐LDL. This feature allows the selection of P1 as a sensitive probe to directly visualize ferroptosis and Cu2+‐mediated LDL oxidative aggregation via in situ formation of fluorophore‐bound Ox‐LDL in living cells. The red‐emissive probe Pro‐P1 (λem = 660 nm) is prepared via borate protection of P1, which can be cleaved into P1 under high expression of HOCl and Ox‐LDL condition at the lesion site, resulting in enhanced green emission. The plaque area and size with clear boundaries can be delineated by colorimetric fluorescence imaging and fluorescence lifetime imaging with precise differentiation.
A Layered Bi2Te3@PPy Cathode for Aqueous Zinc‐Ion Batteries: Mechanism and Application in Printed Flexible Batteries
Authors: Zeng Guifang , Sun Qing , Horta Sharona , Wang Shang , Lu Xuan , Zhang Chao Yue , Li Jing , Li Junshan , Ci Lijie , Tian Yanhong , Ibáñez Maria , Cabot Andreu 
Published: August 2023

AbstractLow‐cost, safe, and environmental‐friendly rechargeable aqueous zinc‐ion batteries (ZIBs) are promising as next‐generation energy storage devices for wearable electronics among other applications. However, sluggish ionic transport kinetics and the unstable electrode structure during ionic insertion/extraction hamper their deployment. Herein, a new cathode material based on a layered metal chalcogenide (LMC), bismuth telluride (Bi2Te3), coated with polypyrrole (PPy) is proposed. Taking advantage of the PPy coating, the Bi2Te3@PPy composite presents strong ionic absorption affinity, high oxidation resistance, and high structural stability. The ZIBs based on Bi2Te3@PPy cathodes exhibit high capacities and ultra‐long lifespans of over 5000 cycles. They also present outstanding stability even under bending. In addition, here the reaction mechanism is analyzed using in situ X‐ray diffraction, X‐ray photoelectron spectroscopy, and computational tools and it is demonstrated that, in the aqueous system, Zn2+ is not inserted into the cathode as previously assumed. In contrast, proton charge storage dominates the process. Overall, this work not only shows the great potential of LMCs as ZIB cathode materials and the advantages of PPy coating, but also clarifies the charge/discharge mechanism in rechargeable ZIBs based on LMCs.
Onlinization of a simulation course that includes minor emergency procedures
Authors: Matsubara Tomoyasu , Numata Kenji , Inaba Takashi , Maeno Tetsuhiro 
Published: August 2023

AbstractAimWe attempted to convert a simulation course held on‐site for primary care physicians to learn about the initial treatment of minor emergencies, including some common surgical procedures, to an online format.MethodsWe reviewed the subjects covered in the course and evaluated whether it was “decision‐making” or “technical skills” that had been primarily taught as simulation‐based training for each subject, and then supplemented the contents accordingly.ResultsAs a result, satisfaction levels with the online course were comparable to those with the on‐site course as measured by a postcourse questionnaire (97.6% [83/85 participants] rating it as “excellent” or “good” on a 5‐point Likert scale postcourse questionnaire).ConclusionWe showed that it is reasonable to offer simulation in place of in‐person training even for some procedures that were once assumed to be difficult to teach online. Of note, the online course is not just a replacement for the on‐site course; it can offer other benefits, including opportunities for those who have difficulty attending courses due to distance or work‐related reasons. After the COVID‐19 pandemic period, both onsite and online courses can be held, allowing participants to choose the style of course that best suits their situation.
Facile Borylation of Alkenes, Alkynes, Imines, Arenes and Heteroarenes with N‐Heterocyclic Carbene‐Boranes and a Heterogeneous Semiconductor Photocatalyst
Authors: Xie Fukai , Mao Zhan , Curran Dennis P. , Liang Hongliang , Dai Wen 
Published: August 2023

AbstractAlthough the development of radical chain and photocatalytic borylation reactions using N‐heterocyclic carbene (NHC)‐borane as boron source is remarkable, the persistent problems, including the use of hazardous and high‐energy radical initiators or the recyclability and photostability issues of soluble homogeneous photocatalysts, still leave great room for further development in a sustainable manner. Herein, we report a conceptually different approach toward highly functionalized organoborane synthesis by using recoverable ultrathin cadmium sulfide (CdS) nanosheets as a heterogeneous photocatalyst, and a general and mild borylation platform that enables regioselective borylation of a wide variety of alkenes (arylethenes, trifluoromethylalkenes, α,β‐unsaturated carbonyl compounds and nitriles), alkynes, imines and electron‐poor aromatic rings with NHC‐borane as boryl radical precursor. Mechanistic studies and density functional theory (DFT) calculations reveal that both photogenerated electrons and holes on the CdS fully perform their own roles, thereby resulting in enhancement of photocatalytic activity and stability of CdS.
Management of physical and chemical water quality in Kotchener drain (Kafr El Sheikh, Egypt)
Authors: Osman Walaa S. , Ali Dina , Bhran Ahmed A. , Hassanean Mohamed H. , Shoaib Abeer M. 
Published: August 2023

AbstractMinimization of freshwater consumption is very important in the management of water quality in drainage systems. In this paper, a mathematical technique for mass integration in drain systems was proposed. The main objective of this work is to manage the water quality in Kotchener drain (El‐Gharbia main drain) by chasing the physical and chemical parameters at sources and sinks. Kotchener drain is one of the largest drains in the Nile delta which moves from south of Egypt to the Mediterranean Sea in the north direction. Firstly, the data were collected from the studied area for 2 years along the Kotchener drain area. This was achieved by monthly monitoring five parameters of six sources sites and five sinks' sites. The results reveal that the concentration of the sources parameters in catchment area are within the permissible limits, except major constituents of total dissolved solid (TDS), chemical oxygen demand (COD), and biological oxygen demand (BOD). According to the degree of pollutants in the Kotchener drain area, the effective parameters that affected the irrigation along the Nile delta were studied. Secondly, a mathematical model was constructed by input the data of sinks, sources, and discharge point to Mediterranean Sea. Distribution of wastewater and freshwater between sources and sinks were studied according to the limiting mass loads of sources and sinks. Furthermore, the variables were optimized by applying LINGO Software with adding assumptions and constrains. The most effective network with minimal negative environmental impact was obtained. Application of the introduced mathematical approach results in minimizing the freshwater consumption with minimizing the wastewater discharge.
Sulfur‐Decorated Ti3C2TX MXene for High‐Performance Sodium/Potassium‐Ion Batteries
Authors: Guo Zhendong , Dong Guangsheng , Zhang Man , Gao Musen , Shao Leijun , Chen Meng , Liu Hongli , Ni Mingchen , Cao Dianxue , Zhu Kai 
Published: August 2023

AbstractAs post‐lithium ion batteries, both sodium‐ion batteries (SIBs) and potassium ion batteries (PIBs) possess great potential for large scale energy storage. However, the application of both SIBs and PIBs are hindered by the lack of suitable electrode materials. Here, we synthesized the sulfur decorated Ti3C2Tx (S−T3C2Tx) MXene as electrode material for SIBs and PIBs. Thanks to the sulfur functional group and the formation of Ti−S bond, which facilitates the sodium in‐/desertion and strengthens the potassium ion adsorption ability, as well as enhances ion reaction kinetics and improved structure stability, the S−T3C2Tx exhibit excellent sodium/potassium storage performance, high reversible capacities of 151 and 101 mAh g−1 at 0.1 mA g−1 were achieved for SIBs and PIBs, respectively. Moreover, the S−T3C2Tx exhibits remarkable long‐term capacity stability at a high density of 500 mA g−1, providing an impressive storage of 88 mAh g−1 for SIBs and 41 mAh g−1 for PIBs even after 2000 cycles. This work could give a deep comprehension of the heteroatom modification influence on the MXene‐based framework and promote the application of MXene electrodes.
Self‐assembly of molecular beacons through metal ion coordination for fluorescence imaging of miRNA in living cells
Authors: Yang Chan , Li Fenfen , Mo Liuting , Lin Weiying 
Published: August 2023

AbstractFluorescence nanosensors based on functional nucleic acids have been explored as a powerful sensing platform for disease‐relevant miRNAs. This work developed a new hybrid nanosensor (Zr‐B) through coordination‐driven self‐assembly of Zr ions and beacons. The prepared nanosensor exhibited high loading efficiency of beacons and could achieve sensitive and specific detection for miRNAs. The hybrid nanosensor could transfer beacons into living cells efficiently and maintain high stability and biocompatibility in the biological environment, achieving effective miRNA fluorescence imaging in living cells. Therefore, the resultant nanosensor holds potential for applications in disease diagnostics.
Synthesis, characterization, and anticancer evaluation of novel 4‐hydrazinothiazole analogs
Authors: Break Shorook Yasser , Hossan Aisha , Farouk Asmaa 
Published: August 2023

AbstractSingle‐step synthesis of novel 4‐hydrazinothiazole derivatives 6a–e was achieved under mild conditions using the sequential four‐components method involving isothiocyanate, aminoguanidine, carbonyl adduct, and α‐haloketone derivatives. Deprotection of these hydrazinothiazoles was influenced by acylation, providing a novel group of diacylated molecular structures with a broader scope for the design of thiazolyl‐containing drugs 7a and 7b. FTIR, 1H/13C NMR, LC–MS spectroscopy, and CHN elemental analyses were used to study the compound chemical structures. Using a 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay on human periodontal ligament fibroblast (HPDLF) cells, the 4‐hydrazinothiazole derivatives were screened for cytotoxicity in an in vitro cytotoxicity investigation. The 4‐hydrazinothiazole compound 6b bearing an isopropylidene‐hydrazino group demonstrated strongly potent cytotoxicity against CAKI1 (IC50 = 1.65 ± 0.24 μM) and A498 (IC50 of 0.85 ± 0.24 μM). Furthermore, the chloroacetyl‐containing thiazole compound 7a displayed efficient inhibition of growth against the test cell lines CAKI1 and A498 at low micromolar concentrations, IC50 0.78 and 0.74 μM, respectively.