bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Entropy Engineering for Broadband Infrared Radiation
Authors: Wang Wei‐Ming , Liu Bao‐Hua , He Cheng‐Yu , Zhao Peng , Zhao Shi‐Jie , Wang Zeng‐Qiang , Lu Zhong‐Wei , Guo Hui‐Xia , Ren Guo‐Yu , Liu Gang , Gao Xiang‐Hu 
Published: July 2023

AbstractDeveloping high‐performance infrared (IR) radiation materials with desired broadband emissivity, excellent thermal stability, and scalable fabrication processes is highly desirable for energy‐saving applications and heat dissipation. However, it remains a grand challenge to concurrently meet these requirements in existing IR radiation materials. Herein, a high‐entropy (HE) approach is employed to advance the IR radiation performance of spinel oxide. This strategy efficiently narrows the bandgap due to the enhanced electron transitions and the introduction of oxygen vacancies (Ov), variable‐valence behavior, and orbital hybridization. In addition, the lattice distortion effect lowers the symmetry of lattice vibration. Therefore, the resulting HE spinel oxide exhibits near‐blackbody radiation performance, with its emissivity approximately three times higher than that of the binary spinel oxide. Moreover, the entropy‐dominating phase stabilization effect contributes to impressive thermal stability (stable at 1300 °C for 100 h). This makes it suitable for high‐temperature thermal radiation applications, such as energy conservation in industrial high‐temperature furnaces. More importantly, the HE spinel oxide can be readily spray‐coated on various substrates. And the coating on stainless steel reaches an outstanding emissivity of 0.943 in the 0.78−16 µm wavelength range. All these merits render the HE approach competitive for the development of high‐emissivity and thermally stable thermal radiation materials.
Unusual Post Modulation of Pore Size, Nanostructure, and Composition of Metal–Organic Frameworks via Cooperative Ozone/Water Co‐Etching
Authors: Mao Dongling , Huang Guoqing , Wu Lei , Hu Zeyu , Lou Yao‐Yin , Wu Winston Duo , Wu Zhangxiong 
Published: July 2023

AbstractRational engineering of pore structure and size, nanostructure, and local composition of metal‐organic frameworks (MOFs) plays a crucial role for their applications. Herein, a facile O3/H2O co‐etching strategy is reported to treat ZIF‐67 to synthesize derivatives with novel and hard‐to‐acquire structures and properties, including mesoporous ZIF‐67 dodecahedra with variable mesopore sizes (3–30 nm), core–shell and core‐void‐shell mesoporous ZIF‐67@amorphous cobalt hydroxide dodecahedra, and hollow dodecahedral frameworks. In the cooperative etching mechanism, O3 diffuses into the hydrophobic ZIF‐67 to progressively oxidize the ligand to create functional groups, mesopores and voids, while the enhanced hydrophilicity and pore size allow H2O to diffuse inside to hydrolyze the metal centers to form cobalt hydroxide shells. The co‐etching boosts the performance of ZIF‐67 in the electrocatalytic oxygen evolution reaction. The derived core‐void‐shell material possesses a highly attractive performance (an overpotential of 286 mV, a Tafel slope of 59.5 mV dec−1, and a stability of >20 h) because of the presence of amorphous cobalt species, large pores, hierarchal structure, and high hydrophilicity. This work provides a general approach for post engineering of MOFs to create novel structures and functionalities.
Super‐White Boron Nitride Aerogel‐Enabled High‐Energy Laser Irradiation Protection
Authors: Chai Yushan , Li Guangyong , Ji Xiaofei , Zhang Xuetong 
Published: July 2023

AbstractAerogels are ultralight solid materials with three‐dimensional interconnected porous structures that offer considerable advantages for various protective applications. Lasers have led to various technological revolutions in aerospace, medical science, and industrial manufacturing. However, shielding against high‐energy laser irradiation using aerogels has rarely been reported. A super‐white (reflectivity >98%) boron nitride (BN) aerogel constructed using BN nanoribbons is developed in this study for high‐energy laser protection. Large numbers of BN nanoribbons serve as randomized and disordered optical nanobarriers for intense backlight scattering, which contribute to high broadband reflectivity. Combined with the low thermal conductivity of the aerogel structure and the excellent high‐temperature stability of BN, the resulting BN aerogel exhibits a high protective threshold of 2.1 × 104 W cm−2. Moreover, the BN aerogel possesses a soft porous network and a low thermal expansion coefficient, which is promising for tolerating the thermal stress and shock of local high‐temperature fields caused by laser irradiation. The successful laser shielding by the super‐white BN aerogel may be helpful for designing and fabricating advanced aerogel‐based lightweight anti‐laser materials.
The Impact of Culture Variables on a 3D Human In Vitro Bone Remodeling Model: A Design of Experiments Approach
Authors: de Wildt Bregje W. M. , Cuypers Lizzy A. B. , Cramer Esther E. A. , Wentzel Annelieke S. , Ito Keita , Hofmann Sandra 
Published: July 2023

AbstractHuman in vitro bone remodeling models, using osteoclast–osteoblast cocultures, can facilitate the investigation of human bone remodeling while reducing the need for animal experiments. Although current in vitro osteoclast–osteoblast cocultures have improved the understanding of bone remodeling, it is still unknown which culture conditions support both cell types. Therefore, in vitro bone remodeling models can benefit from a thorough evaluation of the impact of culture variables on bone turnover outcomes, with the aim to reach balanced osteoclast and osteoblast activity, mimicking healthy bone remodeling. Using a resolution III fractional factorial design, the main effects of commonly used culture variables on bone turnover markers in an in vitro human bone remodeling model are identified. This model is able to capture physiological quantitative resorption–formation coupling along all conditions. Culture conditions of two runs show promising results: conditions of one run can be used as a high bone turnover system and conditions of another run as a self‐regulating system as the addition of osteoclastic and osteogenic differentiation factors is not required for remodeling. The results generated with this in vitro model allow for better translation between in vitro studies and in vivo studies, toward improved preclinical bone remodeling drug development.
High‐Throughput Screening of Surface Engineered Cyanine Nanodots for Active Transport of Therapeutic Antibodies into Solid Tumor
Authors: Qin Yating , Wang Guowei , Chen Linying , Sun Yuji , Yang Jiajia , Piao Ying , Shen Youqing , Zhou Zhuxian 
Published: July 2023

AbstractThe successful delivery of therapeutic biomacromolecules into solid tumor holds great challenge due to their high resistance to penetrate through the complex tumor microenvironments. Here, active‐transporting nanoparticles are harnessed to efficiently deliver biomacromolecular drugs into solid tumors through cell transcytosis. A series of molecularly precise cyanine 5‐cored polylysine G5 dendrimers (Cy5 nanodots) with different peripheral amino acids (G5‐AA) is prepared. The capability of these positively charged nanodots to induce cell endocytosis, exocytosis, and transcytosis is evaluated via fluorescence‐based high‐throughput screen. The optimized nanodots (G5‐R) are conjugated with αPD‐L1 (a therapeutic monoclonal antibody binding to programmed‐death ligand 1) (αPD‐L1‐G5‐R) to demonstrate the nanoparticle‐mediated tumor active transport. The αPD‐L1‐G5‐R can greatly enhance the tumor‐penetration capability through adsorption‐mediated transcytosis (AMT). The effectiveness of αPD‐L1‐G5‐R is tested in treating mice bearing partially resected CT26 tumors, mimicking the local immunotherapy of residual tumors post‐surgery in clinic. The αPD‐L1‐G5‐R embedded in fibrin gel can efficiently mediate tumor cell transcytosis, and deliver αPD‐L1 throughout the tumor, thereby enhancing immune checkpoint blockade, reducing tumor recurrence, and significantly prolonging the survival time. The active‐transporting nanodots are promising platforms for efficient tumor delivery of therapeutic biomacromolecules.
Controlled Synthesis and Accurate Doping of Wafer‐Scale 2D Semiconducting Transition Metal Dichalcogenides
Authors: Li Xiaohui , Yang Junbo , Sun Hang , Huang Ling , Li Hui , Shi Jianping 
Published: July 2023

Abstract2D semiconducting transition metal dichalcogenide (TMDCs) possess atomically thin thickness, a dangling‐bond‐free surface, flexible band structure, and silicon‐compatible feature, making them one of the most promising channels for constructing state‐of‐the‐art field‐effect transistors in the post‐Moore's era. However, the existing 2D semiconducting TMDCs fall short of meeting the industry criteria for practical applications in electronics due to their small domain size and the lack of an effective approach to modulate intrinsic physical properties. Therefore, it is crucial to prepare and dope 2D semiconducting TMDCs single crystals with wafer size. In this review, the up‐to‐date progress regarding the wafer‐scale growth of 2D semiconducting TMDC polycrystalline and single‐crystal films is systematically summarized. The domain orientation control of 2D TMDCs and the seamless stitching of unidirectionally aligned 2D islands by means of substrate design are proposed. In addition, the accurate and uniform doping of 2D semiconducting TMDCs and the effect on electronic device performances are also discussed. Finally, the dominating challenges pertaining to the enhancement of the electronic device performances of TMDCs are emphasized, and further development directions are put forward. This review provides a systematic and in‐depth summary of high‐performance device applications of 2D semiconducting TMDCs.
Anlotinib Combined with Anti‐PD1 Potentiates Anti‐Tumor Immunity via Immunogenic Cell Death and Macrophage Reprogramming
Authors: Zou Benkun , Jiang Haohua , Liu Hongyu , Lu Jun , Qiang Huiping , Lu Mingfang , Yu Lian , Zhong Hua , Chu Tianqing , Han Baohui 
Published: July 2023

AbstractThe combination therapy of targeted drugs and immune checkpoint inhibitors has shown prominent success. In addition to blocking mutated oncogene downstream signaling, the immunological mechanism(s) underlying the anti‐tumor effect of targeted‐immuno‐therapy is not clear. In this study, anlotinib, a novel pan‐targeted tyrosine kinase receptor inhibitor (pTKI), is combined with anti‐PD1 (αPD1) as a therapeutic regimen applying to an immunocompetent mouse tumor model. Anlotinib induces immunogenic cell death (ICD), elicits anti‐tumor inflammation and infiltration, and activation of DCs and CD8+ T cells, which are enhanced by αPD1. Furthermore, anlotinib reduces KC/MCP‐1 secretion by attenuating educational effect that cancer cells imposed on tumor‐associated macrophages (TAMs) and prevents their M2 polarization by inhibiting AKT/mTORC1 and Pparδ pathways. Importantly, anlotinib plus αPD1 prolongs median progression‐free survival time compared with standard chemotherapy plus pembrolizumab as the 1st line treatment in non‐small cell lung cancer (NSCLC) patients. Thus, anlotinib treatment elicits both innate and adaptive anti‐tumor immune responses while αPD1 enhances its potency. This study provides strong evidence that combination of targeted therapy and immunotherapy is a promising regimen for treating NSCLC.
Estrogen‐Induced LncRNA, LINC02568, Promotes Estrogen Receptor‐Positive Breast Cancer Development and Drug Resistance Through Both InTrans and In Cis Mechanisms
Authors: Chen Xue , Ding Jian‐cheng , Hu Guo‐sheng , Shu Xing‐yi , Liu Yan , Du Jun , Wen Zi‐jing , Liu Jun‐yi , Huang Hai‐hua , Tang Guo‐hui , Liu Wen 
Published: July 2023

AbstractEndocrine therapy is the frontline treatment for estrogen receptor (ER) positive breast cancer patients. However, the primary and acquired resistance to endocrine therapy drugs remain as a major challenge in the clinic. Here, this work identifies an estrogen‐induced lncRNA, LINC02568, which is highly expressed in ER‐positive breast cancer and functional important in cell growth in vitro and tumorigenesis in vivo as well as endocrine therapy drug resistance. Mechanically, this work demonstrates that LINC02568 regulates estrogen/ERα‐induced gene transcriptional activation in trans by stabilizing ESR1 mRNA through sponging miR‐1233‐5p in the cytoplasm. Meanwhile, LINC02568 contributes to tumor‐specific pH homeostasis by regulating carbonic anhydrase CA12 in cis in the nucleus. The dual functions of LINC02568 together contribute to breast cancer cell growth and tumorigenesis as well as endocrine therapy drug resistance. Antisense oligonucleotides (ASO) targeting LINC02568 significantly inhibits ER‐positive breast cancer cell growth in vitro and tumorigenesis in vivo. Furthermore, combination treatment with ASO targeting LINC02568 and endocrine therapy drugs or CA12 inhibitor U‐104 exhibits synergistic effects on tumor growth. Taken together, the findings reveal the dual mechanisms of LINC02568 in regulating ERα signaling and pH homeostasis in ER‐positive breast cancer, and indicated that targeting LINC02568 might represent a potential therapeutic avenue in the clinic.
Examining the Electrochemical Properties of Hybrid Aqueous/Ionic Liquid Solid Polymer Electrolytes through the Lens of Composition‐Function Relationships
Authors: Ludwig Kyle B. , Correll‐Brown Riordan , Freidlin Max , Garaga Mounesha N. , Bhattacharyya Sahana , Gonzales Patricia M. , Cresce Arthur V. , Greenbaum Steven , Wang Chunsheng , Kofinas Peter 
Published: July 2023

AbstractSolid polymer electrolytes (SPEs) have the potential to meet evolving Li‐ion battery demands, but for these electrolytes to satisfy growing power and energy density requirements, both transport properties and electrochemical stability must be improved. Unfortunately, improvement in one of these properties often comes at the expense of the other. To this end, a “hybrid aqueous/ionic liquid” SPE (HAILSPE) which incorporates triethylsulfonium‐TFSI (S2,2,2) or N‐methyl‐N‐propylpyrrolidinium‐TFSI (Pyr1,3) ionic liquid (IL) alongside H2O and LiTFSI salt to simultaneously improve transport and electrochemical stability is studied. This work focuses on the impact of HAILSPE composition on electrochemical performance. Analysis shows that an increase in LiTFSI content results in decreased ionic mobility, while increasing IL and water content can offset its impact. pfg‐NMR results reveal that preferential lithium‐ion transport is present in HAILSPE systems. Higher IL concentrations are correlated with an increased degree of passivation against H2O reduction. Compared to the Pyr1,3 systems, the S2,2,2 systems exhibit a stronger degree of passivation due to the formation of a multicomponent interphase layer, including LiF, Li2CO3, Li2S, and Li3N. The results herein demonstrate the superior electrochemical stability of the S2,2,2 systems compared to Pyr1,3 and provide a path toward further enhancement of HAILSPE performance via composition optimization.
Do contrasting socio‐ecological conditions bring difference in premenstrual syndrome and its concomitants? A sedente‐migrant comparative study from Eastern India
Authors: Thakur Joyeeta , Goswami Monali , Roy Subho 
Published: July 2023

AbstractObjectivesWe asked in our research whether the premenstrual syndrome (PMS) and its concomitants, differ between “sedente” and “migrant” populations hailing from the same ethnic group, owing to their living in contrasting socio‐ecological conditions.MethodsA total of 501 Oraon adolescents (sedente: 200, migrant: 301) were studied. Data on PMS was reported retrospectively using a list of 29 standard symptoms. Principal component analysis (PCA) was applied on PMS. PCA, which resulted in six principal components (PC1 to PC6) were loaded with “behavioral and cognitive,” “negative mood,” “pain and fluid retention,” “vestibular and breast tenderness,” and “fatigue,” and/or “gastrointestinal” symptoms. Step‐wise hierarchical regression was applied using migration status (step 1), socio‐demographic (step 2), menstrual (step 3), and nutritional and lifestyle variables (step 4) as concomitants for each principal component.ResultsSignificantly, a greater number of migrants reported PMS but of milder intensity, unlike the sedentes. Significant sedente‐migrant differences were found in the concomitants for PMS. Multivariate analyses showed differential socio‐demographic (occupational, educational and wealth status, religion), nutritional (dietary carbohydrate protein and fat, tea intake, body mass index, percent body fat, waist hip ratio, fat mass index), menstrual (age at menarche, cycle length, dysmenorrhoea) and anemic status of the sedentes and the migrants were significantly associated with PMS.ConclusionsSedente and migrant participants, despite hailing from the same ethnic group, sharply differed in the prevalence of PMS and its concomitants owing to their living in contrasting socio‐ecological conditions.
Locating Hydrogen Positions for COF‐300 by Cryo‐3D Electron Diffraction
Authors: Sun Wenjia , Chen Pohua , Zhang Mingxuan , Ma Jian‐Xin , Sun Junliang 
Published: July 2023

AbstractCovalent organic frameworks (COFs) have wide‐ranging applications, and their host–guest interactions play an essential role in the achievement of COF functions. To investigate these host–guest interactions, it is necessary to locate all atoms, especially hydrogen atoms. However, it is difficult to determine the hydrogen atomic positions in COFs because of the complexities in synthesizing high‐quality large single crystals. Three‐dimensional electron diffraction (3D ED) has unique advantages for the structural determination of nanocrystals and identification of light atoms. In this study, it was demonstrated for the first time that the hydrogen atoms of a COF, not only on the framework but also on the guest molecule, can be located by 3D ED using continuous precession electron diffraction tomography (cPEDT) under cryogenic conditions. The host–guest interactions were clarified with the location of the hydrogen atoms. These findings provide novel insights into the investigation of COFs.
Decoding Protein Dynamics in Cells Using Chemical Cross‐Linking and Hierarchical Analysis**
Authors: Zhang Beirong , Gong Zhou , Zhao Lili , An Yuxin , Gao Hang , Chen Jing , Liang Zhen , Liu Maili , Zhang Yukui , Zhao Qun , Zhang Lihua 
Published: July 2023

AbstractProtein dynamics play a crucial role in their diverse functions. The intracellular environment significantly influences protein dynamics, particularly for intrinsically disordered proteins (IDPs). To comprehensively capture structural information from various proteins within cells and characterize protein dynamics, chemical cross‐linking mass spectrometry was employed. In this study, we introduce a hierarchical decoding strategy that enables the investigation of protein dynamics in vivo. Computational analysis based on distance restraints derived from cross‐links is used to infer protein dynamics in cells. To facilitate this analysis, we leverage the prior structure obtained from AlphaFold2. By employing this strategy, we can characterize the full‐length structure of multi‐domain proteins taking into account their distinct dynamic features. Furthermore, by combining restraint sampling with an unbiased sampling and evaluation approach, we can provide a comprehensive description of the intrinsic motion of IDPs. Consequently, the hierarchical strategy we propose holds significant potential in advancing our understanding of the molecular mechanisms that undelie protein functions in cells.
A novel epoxy resin system containing bismaleimide and DOPO‐based flame retardant with excellent flame retardancy and toughness
Authors: Liu Zhengbiao , Zhang Yijun , Jia Zhiwei , Liu Hua , Liu Zuozhen 
Published: July 2023

Abstract9,10‐dihydro‐9‐oxo‐10‐phosphaphenanthrene‐10‐oxide (DOPO) and special tetra functional epoxy resin (EP) AG‐601 were combined to synthesize a reactive flame retardant (FREP) and then incorporated into EP, obtaining the flame retardant material EP/FREP. To achieve EPs with higher flame retardancy and mechanical properties, a new intrinsically flame retardant EP system named EP/FRDM was produced by modifying EP/FREP with high thermal resistance bismaleimide (BDM). In the presence of a distinct FRDM structure comprising phosphaphenanthrene/nitrogen, the EP possessed superior flame retardancy and impact toughness. The curing process of EP/FRDM was investigated using Real‐Time Fourier‐transform Infrared. In terms of fire performance, the limiting oxygen index of the EP/FRDM‐3 was raised from 31.4% to 38.2%, and the vertical burning rating was improved after BDM was added to the EP/FREP system. It was discovered that EP/FRDM exhibited a classic two‐phase flame retardant influence by analyzing the residual carbon morphology and pyrolysis behavior. Simultaneously, the glass transition temperature (Tg) of EP/FRDM remained essentially stable, and the char residue yield rose markedly, which indicated that the system had outstanding thermal stability, according to the results of the dynamic mechanical analysis and thermogravimetric analysis tests. Notably, the EP/FRDM experienced an internal chain expansion reaction when BDM was added, giving flame retardant materials excellent flexural and impact strengths and promising future application opportunities.
Correlation between non‐isothermal crystallization kinetics and morphology in poly(ε‐caprolactone)/poly(styrene‐co‐acrylonitrile) blends considering the blend phase behavior: Effects of poly(ε‐caprolactone) molecular weight
Authors: Khadivi Elahe , Khonakdar Hanieh , Salkhi Khasraghi Samaneh , Hemmati Farkhondeh , Salahshoori Iman , Ehsani Morteza , Arnhold Kerstin , Khonakdar Hossein Ali 
Published: July 2023

AbstractNon‐isothermal crystallization of poly(ε‐caprolactone) (PCL) in semi‐crystalline/amorphous PCL/poly(styrene‐co‐acrylonitrile) (SAN) blends with lower‐critical solution temperature (LCST) phase behavior at temperatures higher than the beginning of PCL crystallization has been studied and quantitatively modeled using different kinetics models. Near‐ and off‐critical PCL/SAN blends were prepared by using two different PCL molecular weights. The kinetics model results verified that the samples containing PCL with higher molecular weight have lower crystallinity and faster crystallization behavior, while adding amorphous SAN chains to PCL retards the crystallization process. A lower crystallization activation energy was relatively required for higher molecular weight, PCL‐2, in off‐critical PCL/SAN blends. However, the easier crystallization with higher degree of crystallinity was attained in near‐critical P80S20 blend containing PCL with lower molecular weight, indicating a shift of the LCST phase diagram of the PCL/SAN blend to higher temperatures by increasing the PCL molecular weight.
Controllability of fractional dynamical systems with distributed delays in control using ψ‐Caputo fractional derivative
Authors: Panneer Selvam Anjapuli , Govindaraj Venkatesan 
Published: July 2023

AbstractThis research investigates the controllability of linear and non‐linear fractional dynamical systems with distributed delays in control using the
‐Caputo fractional derivative. For controllability of linear systems, the positive definiteness of Grammian matrix, which is characterized by Mittag–Leffler functions, is used to provide necessary and sufficient conditions. For the controllability of non‐linear systems, the iterative technique with the completeness of
is used to obtain sufficient conditions. Using the
‐Caputo fractional derivative, this study is new since it investigates the ideas of controllability. A couple of numerical results are offered to explain the theoretical results.